Document:

EX-10.11

 Exhibit 10.11 
 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. 
 Master Collaboration Agreement 
 by and between 

bluebird bio, Inc. 
 and 
 Celgene Corporation 

March 19, 2013 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 Table of Contents 

 

							
	 	    	 	  	Page	 
			
	 1.
	    	Definitions	  	 	1	  
			
	 2.
	    	Collaboration Program	  	 	11	  
			
	 3.
	    	Governance	  	 	17	  
			
	 4.
	    	Third Party Licenses	  	 	20	  
			
	 5.
	    	Option for Licensed Candidates	  	 	22	  
		
	 [***]
	  			
		
	 [***]
	  			
			
	 8.
	    	Payments	  	 	29	  
			
	 9.
	    	Patent Prosecution and Maintenance	  	 	30	  
			
	 10.
	    	Confidentiality	  	 	33	  
			
	 11.
	    	Warranties; Limitations of Liability; Indemnification	  	 	37	  
			
	 12.
	    	Term and Termination	  	 	42	  
			
	 13.
	    	General Provisions	  	 	48	  

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 List of Exhibits 

 

			
	Exhibit A	    	License Agreement
		
	Exhibit B	    	Co-Development, Co-Promote and Profit Share Agreement
		
	[***]	    	
		
	[***]	    	
		
	[***]	    	
		
	Exhibit F	    	Additional Celgene Option Information
		
	[***]	    	
		
	Exhibit H	    	Redacted Master Collaboration Agreement
		
	Exhibit I	    	Press Release
		
	[***]	    	
		
	[***]	    	
		
	Exhibit L	    	Call Option

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 Master Collaboration Agreement 

This Master Collaboration Agreement (this “Agreement”), dated as of March 19, 2013, 2013
(the “Effective Date”), is made by and between bluebird bio, Inc., a Delaware corporation (“Bluebird”), and Celgene Corporation, a Delaware corporation (“Celgene”). Each of Bluebird and
Celgene may be referred to herein as a “Party” or together as the “Parties.” 

WHEREAS, Bluebird has developed and owns or has rights to certain Patents and technology relating to developing innovative gene therapies
for genetic disorders; 
 WHEREAS, Celgene is a biopharmaceutical company focused on acquiring, Developing and Commercializing
innovative anti-cancer agents; and 
 WHEREAS, the Parties are interested in collaborating together to research, develop and
commercialize therapeutic products in the Field, all in accordance with the terms and conditions set forth below; 
 NOW,
THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the amount and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 

 

	1.	Definitions. 

 The following terms
and their correlatives will have the following meanings: 
 1.1 “Affiliate” of a Person means any other Person
which (directly or indirectly) is controlled by, controls or is under common control with such Person. A Person will be deemed to “control” another Person if it: (a) with respect to such other Person that is a corporation, owns,
directly or indirectly, beneficially or legally, at least fifty percent (50%) of the outstanding voting securities or capital stock (or such lesser percentage which is the maximum allowed to be owned by such Person in a particular jurisdiction)
of such other Person, or, with respect to such other Person that is not a corporation, has other comparable ownership interest; or (b) has the power, whether pursuant to contract, ownership of securities or otherwise, to direct the management
and policies of such other Person. 
 1.2 “Baylor” means Baylor College of Medicine. 

1.3 “Baylor Agreements” means (i) the Research and Collaboration Agreement (dated as of the date hereof) by and
between Baylor and Celgene (“Baylor Research Agreement”), (ii) the Platform Technology License Agreement (dated as of the date hereof) by and between Baylor and Celgene (“Baylor Platform License”), and
(iii) any Product License Agreement (“Baylor Product License”), in each case ((i) – (iii)) as may be amended or restated. 
 1.4 “Biologics License Application” or “BLA” means, with respect to a country or extra-national territory, a request for permission to introduce, distribute, sell or
market a biologic product in such country or some or all of such extra-national territory, including pursuant to 21 CFR 601.2 in the U.S. 
 1.5 “Bluebird In-Licensed IP” means all Patents, Materials and Know-How in-licensed by Bluebird or its Affiliates during the Collaboration Program Term pursuant to Bluebird In-Licenses
that are necessary or useful to perform the Collaboration Program. 

  
 1 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 1.6 “Bluebird In-Licenses” means Pre-Existing In-Licenses and Bluebird
Collaboration In-Licenses. 
 1.7 “Bluebird IP” means (i) Collaboration IP solely owned by Bluebird
pursuant to Section 2.1(f), (ii) Bluebird In-Licensed IP and (iii) all Patents, Materials and Know-How Controlled by Bluebird or its Affiliates (other than Bluebird In-Licensed IP), in each case that is necessary or useful to perform
the Collaboration Program. For avoidance of doubt, Collaboration IP jointly owned by the Parties pursuant to Section 2.1(f) will not be deemed Bluebird IP. 
 1.8 “Bluebird New In-License” means a New In-License between Bluebird or any of its Affiliates and a Third Party. 
 1.9 “Business Combination” means with respect to a Party, any of the following events: (i) any Third Party (or group of Third Parties acting in concert as a “group” within
the meaning of Section 13(d) of the Exchange Act) acquires (including by way of a tender or exchange offer or issuance by such Party), directly or indirectly, beneficial ownership or a right to acquire beneficial ownership of shares of such
Party representing fifty percent (50%) or more of the voting shares (where voting refers to being entitled to vote for the election of directors) then outstanding of such Party, but excluding for such purposes any transaction or series of
transactions with Financial Investors made for bona fide equity financing purposes in which cash is received by Bluebird or indebtedness of Bluebird is cancelled or converted or a combination thereof; (ii) such Party consolidates with or merges
into another corporation or entity which is a Third Party, or any corporation or entity which is a Third Party consolidates with or merges into such Party, in either event pursuant to a transaction in which more than fifty percent (50%) of the
voting shares of the acquiring or resulting entity outstanding immediately after such consolidation or merger is not held by the holders of the outstanding voting shares of such Party immediately preceding such consolidation or merger; or
(iii) such Party sells, transfers, leases or otherwise disposes of all or substantially all of its assets to a Third Party. “Financial Investor” means any investor or series of Affiliated investors whose primary business is the
investment of capital for financial gain (including venture capital funds, private equity funds, pension funds and so-called “angel investors”), but in all cases excluding so-called “strategic investors” such as biotechnology
companies, specialty pharmaceutical companies, pharmaceutical companies, generic pharmaceutical companies, and medical device companies and their Affiliates such as strategic venture arms. 

1.10 “CAR” means chimeric antigen receptor. 
 1.11 “Celgene In-Licensed IP” means [***] 
 1.12 “Celgene
In-Licenses” means [***] 
 1.13 “Celgene IP” means, collectively: 

(a) “Celgene Know-How,” which means [***] 
 (b) “Celgene Patents,” which means [***] 
 1.14 “Celgene
New In-License” means a New In-License between Celgene or any of its Affiliates and a Third Party. 

  
 2 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 1.15 “Celgene Pre-Existing In-Licenses” means [***] 

1.16 “cGMP” means all applicable standards relating to manufacturing practices for pharmaceutical products, including
(a) all applicable requirements detailed in the FDA’s current Good Manufacturing Practices regulations, 21 CFR Parts 210 and 211 and The Rules Governing Medicinal Products in the European Community, Volume IV, Good Manufacturing Practice
for Medicinal Products, as each may be amended from time to time, and (b) all applicable Laws promulgated by any governmental authority having jurisdiction over the Manufacture of a Compound, Licensed Compound or Licensed Product, as
applicable. 
 1.17 “Collaboration IP” means all Collaboration Know-How and Patents arising therefrom that
Cover the Collaboration Know-How. 
 1.18 “Collaboration Know-How” means all Know-How and Materials discovered,
created, conceived, developed or reduced to practice in the course of performing activities under the Collaboration Program (whether solely by one Party or jointly by the Parties, in each case with their Affiliates or any Third Parties or any
employees, consultants or agents of any of the foregoing which perform activities under the Collaboration Program). 
 1.19
“Collaboration Program” means the program of research and Development in the Field that is engaged in by or on behalf of the Parties under this Agreement during the Collaboration Program Term. 

1.20 “Commercially Reasonable Efforts” means, with respect to the research and Development of Product Candidates, that
level of efforts and resources that such Party would normally devote to the research or Development, as the case may be, of a product owned by it or to which it has rights of the type it has hereunder, which is of a similar commercial potential at a
similar stage in its lifecycle, in each case taking into account issues of safety and efficacy, product profile, the proprietary position, the then current competitive environment for such product and the likely timing of such product’s entry
into the market, the pricing and launching strategy for the respective product, the regulatory environment and status of such product, and other relevant scientific, technical and commercial factors. 

1.21 “Control” or “Controlled” means, with respect to any Know-How, Material or Patent, the possession
(whether by ownership or license or sublicense) by a Party of the ability to use or practice such Know-How, Material, Patent, Regulatory Data, Regulatory Filings or Regulatory Approvals to perform the Collaboration Program or otherwise to grant to
the other Party a license or access as provided herein to such item, without violating the terms of any agreement or other arrangement with any Third Party or, other than under the Bluebird In-Licenses, being obligated to pay any royalties or other
consideration therefor (“Additional Payments”). For clarity, Bluebird New In-Licenses are not “Controlled” for purposes of this Agreement, unless and only after such Bluebird New In-License is converted into a Bluebird
Collaboration In-License pursuant to Sections 4.1(b) or 4.1(d) and all required payments thereunder have been made by Celgene to Bluebird. For clarity, Celgene In-Licenses are not “Controlled” for purposes of this Agreement, unless and
only after the Parties mutually agree to include such Celgene In-License in the Collaboration Program pursuant to Section 4.1(c). Notwithstanding the foregoing, if on or after the Effective Date and for such time as the other Party agrees to pay and
does in fact pay all 

  
 3 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
Additional Payments with respect to such Party’s access or license to such Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals (other than that
in-licensed by Bluebird pursuant to a Bluebird In-License), such Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals will be deemed to be included in the definition of “Control”. 

1.22 “Covers”, with reference to (i) a Patent, means that the making, using, selling, offering for sale or
importing of a product or practice of a method would infringe a Valid Claim of such Patent in the country in which such activity occurs, and (ii) Materials or Know-How, means that the Manufacture, Development or Commercialization of a product
incorporates, embodies or otherwise makes use of such Know-How. 
 1.23 “Declined Product Candidate
Study” means (i) a Phase 3 Study that is intended by Bluebird (consistent with industry practice) to be submitted (together with any other registration trials that are prospectively planned when such Phase 3 Study is initiated) for
Regulatory Approval of a Declined Product Candidate in the U.S. or the EU, (ii) a Phase  2/3 Study that is intended by Bluebird (consistent with industry practice) to be submitted (together with any other
registration trials that are prospectively planned when such Phase  2/3 Study is initiated) for Regulatory Approval of a Declined Product Candidate in the U.S. or the EU, at such time when
Bluebird obtains data from the Phase 2 portion of such Phase  2/3 Study and commences the Phase 3 portion of such Phase  2/3 Study, or (iii) any other clinical study that is designed to establish that a pharmaceutical product is safe and efficacious for its intended use, and to determine warnings, precautions, and adverse
reactions that are associated with such pharmaceutical product in the dosage range to be prescribed, which clinical study is a registration trial intended to be sufficient for filing an application for a Regulatory Approval for the Declined Product
Candidate in the U.S. or another country or some or all of an extra-national territory, as evidenced by the acceptance for filing for a Regulatory Approval for such product after completion of such study. For purposes of this Agreement,
“completion of a Declined Product Candidate Study” means the date on which a final and complete clinical study report for the Declined Product Candidate Study, based on the complete and cleaned dataset from such Declined Product Candidate
Study, which dataset includes a minimum of three (3) months follow-up of all patients in such Declined Product Candidate Study, is provided to Celgene. 

1.24 “Declined Product Candidate Development Costs” means, with respect to a Declined Product Candidate, Bluebird’s
FTE Costs and out-of-pocket costs directly identifiable or allocable to the Development of such Declined Product Candidate by Bluebird, its Affiliates or others working on their behalf, as applicable, following the date of Bluebird’s delivery
of a Bluebird Development Notice for such Declined Product Candidate. Such costs will be calculated and allocated in accordance with methodologies based on Bluebird’s then current internal accounting systems, consistently applied, and in
accordance with U.S. generally accepted accounting principles or International Financial Reporting Standards, consistently applied. For clarity, Declined Product Candidate Development Costs will include amounts paid by Bluebird to Celgene with
respect to payments due under any Applicable Celgene In-License attributable to Bluebird as a sublicensee thereunder with respect to the Development of such Declined Product Candidate. 

  
 4 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 1.25 “Development” means preclinical and clinical drug development
activities, including: test method development and stability testing, toxicology, formulation, process development, qualification and validation, Manufacture scale-up, development-stage Manufacturing, quality assurance/quality control, clinical
studies, statistical analysis and report writing, the preparation and submission of BLAs and MAAs, regulatory affairs with respect to the foregoing and all other activities necessary or useful or otherwise requested or required by a Regulatory
Authority as a condition or in support of obtaining or maintaining a Regulatory Approval. 
 1.26
“Development & Commercialization Agreements” means the License Agreement attached hereto as Exhibit A and the Co-Development, Co-Promote and Profit Share Agreement attached hereto as Exhibit B. 

1.27 “EMA” means the Regulatory Authority known as either the European Medicines Agency or the European Agency for the
Evaluation of Medicinal Products and any successor agency thereto. 
 1.28 “FDA” means the United States Food
and Drug Administration and any successor agency thereto. 
 1.29 “Field” means the use of (i) T-Cells
expressing a CAR (with or without other engineering to enhance functionality and/or safety), including virus specific genetically modified T-Cells expressing a synthetic CAR, and (ii) T-Cells expressing native-virus antigen receptors or
tumor-specific antigen receptors in which the T-Cells are genetically modified to enhance their performance, persistence or safety, in each case under (i) and (ii) for the treatment, modulation, palliation or prevention of cancer in
humans. 
 1.30 “FTE” means a full-time scientific or technical person, or in the case of less than a full-time
scientific or technical person, a full-time equivalent scientific or technical person year, carried out by an appropriately qualified employee of Bluebird or its Affiliates, based on 1,920 person-hours or greater per year. 

1.31 “FTE Costs” means the actual FTEs employed by Bluebird or its Affiliates in the conduct of Development activities
multiplied by the FTE Rate. 
 1.32 “FTE Rate” means [***] 

1.33 “IND” means an investigational new drug application filed with the FDA for authorization to commence clinical
studies, and its equivalent in a foreign country. 
 1.34 “IND Product Candidate” means any Product Candidate
for which an IND has been filed but for which an initial Phase 1 Study has not been completed as of the effective date of any termination or expiration of the Collaboration Program Term. For clarity, “IND Product Candidates” excludes
Optioned Candidates. 
 1.35 “Know-How” means all commercial, technical, scientific and other know-how and
information, trade secrets, knowledge, technology, methods, processes, practices, formulae, instructions, skills, techniques, procedures, experiences, ideas, technical assistance, designs, drawings, assembly procedures, computer programs,
specifications, data and results (including biological, chemical, pharmacological, toxicological, pharmaceutical, physical and analytical, preclinical, clinical, safety, manufacturing and quality control data and know-how, including

  
 5 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
Regulatory Data, study designs and protocols), in all cases, whether or not confidential, proprietary, patented or patentable, in written, electronic or any other form now known or hereafter
developed. 
 1.36 “Knowledge” means the actual knowledge or good faith understanding of the vice presidents,
senior vice presidents, president or chief executive officer of a Party of the facts and information then in their possession. 

1.37 “Law” or “Laws” means all laws, statutes, rules, regulations, orders, judgments, or ordinances
having the effect of law of any federal, national, multinational, state, provincial, county, city or other political subdivision. 
 1.38 “license” means license or sublicense, as applicable. 
 1.39
“Manufacturing” means the production, manufacture, processing, filling, finishing, packaging, labeling, shipping and holding of product or any intermediate thereof, including process development, process qualification and
validation, scale-up, commercial manufacture and analytic development, product characterization, stability testing, quality assurance and quality control. With reference to any Product Candidate, Manufacturing includes Vector and associated Payload
supply. 
 1.40 “Materials” means any tangible chemical or biological material, including any compounds, DNA,
RNA, clones, Vectors, Payloads, cells, and any expression product, progeny, derivative or other improvement thereto, along with any tangible chemical or biological material embodying any Know-How. 

1.41 “MAA” means an application for the authorization to market a product in any country or group of countries outside
the United States, as defined in the applicable Laws and filed with the Regulatory Authority of a given country or group of countries. 
 1.42 [***] 
 1.43 “Option Fees” means the Initial Option Fee and
the Additional Option Fee. 
 1.44 “Optioned Candidate” means a Product Candidate for which Celgene has
exercised its option pursuant to Sections 5.1 or 5.7. 
 1.45 “Other In-Licenses” means Bluebird
Collaboration In-Licenses that Celgene does not elect to include within the definition of Applicable New In-Licenses in an applicable Development & Commercialization Agreement in accordance with Section 5.8. 

1.46 “Patent” means a patent or a patent application, including any additions, divisions, continuations,
continuations-in-part, invention certificates, substitutions, reissues, reexaminations, extensions, registrations, supplementary protection certificates and renewals, including all U.S. and foreign counterparts thereof, but not including any rights
that give rise to regulatory exclusivity periods (other than supplementary protection certificates, which will be treated as “Patents” hereunder). 
 1.47 “Patent Costs” means the out-of-pocket costs and expenses paid to outside legal counsel and other Third Parties (including to any licensor pursuant to any in-license), and filing and
maintenance expenses, incurred in Prosecuting and Maintaining Patents and enforcing and defending them. 

  
 6 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 1.48 “Payload” means [***] 

1.49 “Person” means any individual, partnership, joint venture, limited liability company, corporation, firm, trust,
association, unincorporated organization, governmental authority or agency, or any other entity not specifically listed herein. 

1.50 “Phase 1 Study” means a clinical trial of a product, the principal purpose of which is preliminary determination of
safety in healthy individuals or patients as described under 21 C.F.R. §312.21(a) (as amended or any replacement thereof), or a similar clinical study prescribed by the Regulatory Authorities in a foreign country. For purposes of this
Agreement, “completion of Phase 1 Study” means the date on which a final and complete clinical study report for the Phase 1 Study, based on an Initial Primary Analysis, is provided to Celgene. “Initial Primary Analysis”
means, with respect to a Phase 1 Study, an analysis performed on the complete and cleaned dataset from such Phase 1 Study, which dataset includes a minimum of three (3) months follow-up of all patients in such Phase 1 Study. 

1.51 “Phase 2/3 Study” means a clinical trial of a product that is (i) initiated to determine the safety and
efficacy in the target patient population, as described in 21 C.F.R. 312.21(b) (as amended or any replacement thereof), or a similar clinical study prescribed by the Regulatory Authorities in a foreign country and (ii) converted to a Phase 3
Study following an interim analysis of safety and efficacy data generated from the initial patents enrolled in such clinical trial. 
 1.52 “Phase 3 Study” means a clinical trial of a product on a sufficient number of subjects that is designed to establish that a pharmaceutical product is safe and efficacious for its
intended use, and to determine warnings, precautions, and adverse reactions that are associated with such pharmaceutical product in the dosage range to be prescribed, which trial is intended to support Regulatory Approval of such product, as
described in 21 C.F.R. 312.21(c) (as amended or any replacement thereof), or a similar clinical study prescribed by the Regulatory Authorities in a foreign country. For purposes of this Agreement and the Development & Commercialization
Agreements, (i) “commencement of Phase 3 Study” for a product means (a) the first dosing of such product in a human patient in a Phase 3 Study, or (b) the date on which the sponsor elects to continue enrollment of patients
in a Phase  2/3 Study following an interim analysis of safety and efficacy data generated from the initial patents enrolled in such Phase
 2/3 Study, and (ii) “completion of Phase 3 Study” means the final dosing of the last patient to be dosed in such Phase 3 Study. 

1.53 “Pre-Existing In-Licenses” means the agreements listed in Exhibit C. 

1.54 “Product Candidate” means a therapeutic candidate designed, discovered or developed as part of the Collaboration
Program that comprises a T-Cell transduced with recombinant viral agent(s) encoding CAR(s) with targeting domain(s) that specifically target Target Antigen(s) and optionally encoding additional protein(s) that may modulate the efficacy and safety of
such therapeutic candidate. 

  
 7 

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 1.55 “Prosecution and Maintenance” means, with regard to a particular
Patent, the preparation, filing, prosecution and maintenance of such Patent, as well as re-examinations, reissues and the like with respect to that Patent, together with the conduct of interferences, the defense of oppositions and other similar
proceedings with respect to that Patent. 
 1.56 “Regulatory Approval” means, with respect to a country or
extra-national territory, any and all approvals (including BLAs and MAAs), licenses, registrations or authorizations of any Regulatory Authority necessary in order to commercially distribute, sell or market a product in such country or some or all
of such extra-national territory, excluding any pricing or reimbursement approvals. 
 1.57 “Regulatory
Authority” means any national (e.g., the FDA), supra-national (e.g., the EMA), regional, state or local regulatory agency, department, bureau, commission, council or other governmental authority, in any jurisdiction in the
world, involved in the granting of Regulatory Approval. 
 1.58 “Regulatory Data” means all information with
respect to a product made, collected or otherwise generated under or in connection with clinical studies and such other tests and studies in patients that are (i) required by applicable Law, or otherwise recommended by Regulatory Authorities,
to obtain or maintain Regulatory Approvals, or (ii) conducted solely in support of pricing or reimbursement for such product or are not otherwise strictly required in order to obtain or maintain Regulatory Approval for such product (including
epidemiological studies, modeling and pharmacoeconomic studies, post-marketing surveillance studies, investigator sponsored studies and health economics studies). 
 1.59 “Regulatory Filings” means any submission to a Regulatory Authority of any appropriate regulatory application together with any related correspondence and documentation, and will
include any submission to a regulatory advisory board, marketing authorization application, and any supplement or amendment thereto. For the avoidance of doubt, Regulatory Filings will include any IND, BLA, MAA or the corresponding application in
any other country or group of countries. 
 1.60 “Target Antigen” means any and all oncology associated
antigens. 
 1.61 “T-Cell” means any of the lymphocytes that mature in the thymus and have the ability to
recognize specific peptide antigens presented by major histocompatibility complex antigens through the receptors on their cell surface. 
 1.62 “Third Party” means any Person other than Bluebird, Celgene and their respective Affiliates. 
 1.63 [***] 
 1.64 [***] 

1.65 “United States” or “U.S.” means the United States of America, including its territories and
possessions, the District of Columbia and Puerto Rico. 
 1.66 “Vector” means [***] 

  
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 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 Definitions for each of the following terms are found in the body of this Agreement as indicated below:

  

			
	 Defined Term
	 	 Location

	Additional Option Fee	 	Section 8.5
	Agreement	 	Preamble
	[***]	 	
	Baylor Field	 	Section 2.1(f)(ii)
	[***]	 	
	Baylor Platform License	 	Section 1.3
	Baylor Product License	 	Section 1.3
	Baylor Research Agreement	 	Section 1.3
	Bluebird	 	Preamble
	Bluebird Acquisition	 	Section 2.1(e)(i)
	Bluebird Business Program	 	Section 2.1(e)(i)
	[***]	 	
	Bluebird Collaboration In-License	 	Section 4.1(b)
	Bluebird Development Notice	 	Section 5.7(a)
	Bluebird Indemnitees	 	Section 11.6(a)
	Bluebird Option Notice	 	Section 5.3
	Bluebird Program Director	 	Section 3.1
	Call Option	 	Section 6.9
	Celgene	 	Preamble
	[***]	 	
	[***]	 	
	Celgene Indemnitees	 	Section 11.6(b)
	Celgene New In-License	 	Section 1.14
	Celgene Option Notice	 	Section 5.1
	Celgene Option Period	 	Section 5.1
	Celgene Program Director	 	Section 3.1
	Collaboration Plan	 	Section 2.1(a)
	Collaboration Program Advisory Committee	 	Section 3.2(c)(xi)
	[***]	 	
	[***]	 	
	Confidential Information	 	Section 10.1(a)
	Corporate Event	 	Section 6.8
	[***]	 	
	[***]	 	
	Declined Product Candidate	 	Section 5.7(a)
	Disclosing Party	 	Section 10.1(a)
	Effective Date	 	Preamble
	[***]	 	
	Financial Investor	 	Section 1.9

  
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AS AMENDED. 
  

			
	 Defined Term
	 	 Location

	First Collaboration Extension Term	 	Section 2.1(d)
	Follow-On Product Candidate	 	Section 5.6
	HSR Act	 	Section 5.9(a)
	HSR Clearance Date	 	Section 5.9(a)
	HSR Filing	 	Section 5.9(a)
	Implementation Date	 	Section 5.9(a)
	Indemnification Claim Notice	 	Section 11.6(c)
	Indemnified Party	 	Section 11.6(c)
	Industry Transaction	 	Section 13.3
	Initial Collaboration Term	 	Section 2.1(d)
	Initial Option Fee	 	Section 8.4
	[***]	 	
	Issuing Party	 	Section 10.3(b)
	JSC	 	Section 3.2(a)
	Litigation Conditions	 	Section 11.6(d)(i)
	Losses	 	Section 11.6(a)
	[***]	 	
	[***]	 	
	New In-Licenses	 	Section 4.1(a)
	[***]	 	
	Party	 	Preamble
	Patent Liaisons	 	Section 3.3(a)
	Patent Committee	 	Section 3.3(a)
	Phase 1 Study Data	 	Section 5.1
	Pre-IND Product Candidate	 	Section 12.4(c)
	Product Candidate In-License	 	Section 4.2
	Program Directors	 	Section 3.1
	Public Offering Submission	 	Section 6.6
	Receiving Party	 	Section 10.1(a)
	Release	 	Section 10.3(b)
	[***]	 	
	Reviewing Party	 	Section 10.3(b)
	Second Collaboration Extension Term	 	Section 2.1(d)
	Securities Act	 	Section 6.6
	[***]	 	
	Sub-Committees	 	Section 3.2(c)(xi)
	Term	 	Section 12.1
	Third Party Claims	 	Section 11.6(a)

  
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AS AMENDED. 
  

	2.	Collaboration Program. 

  

	 	2.1	Collaboration Program. 

(a) General. During the Collaboration Program Term, the Parties will conduct the Collaboration Program on the terms and conditions
set forth in this Agreement to identify, research and Develop Product Candidates. [***] Under the Collaboration Program, Bluebird will be responsible for all research and Development activities performed through completion of the initial Phase 1
Study with respect to each Product Candidate, and Celgene will be a critical advisor for oncology drug development, ex vivo human cell processing, assay development and release testing. Bluebird will keep Celgene reasonably informed of
Bluebird’s research and Development activities and will reasonably consult with Celgene and reasonably consider Celgene’s comments and advice with respect to all material decisions relating to such activities. Research and Development
activities of the Parties with respect to the Collaboration Program will be described in a “Collaboration Plan,” an initial version of which is attached hereto as Exhibit D. Any modifications or amendments to the
Collaboration Plan that are proposed by either Party will be subject to review by the JSC pursuant to and in accordance with the terms of Section 3.2(d) and to the prior written approval of both Parties. The specific Target Antigens that will
be the focus of the Collaboration Program will be defined as soon as practicable [***], and will be set forth in a Collaboration Plan amendment. The selection of Product Candidates for additional work under the Collaboration Program will be subject
to the oversight and supervision of the JSC, provided that if the JSC is unable to unanimously agree with respect to the selection of a Product Candidate for additional work under the Collaboration Program, either Party may, by written notice to the
other Party, have such dispute referred to the Bluebird CEO and the Celgene CEO or in either case his or her designee (who will be a senior executive), who will attempt in good faith to resolve such dispute by negotiation and consultation [***], and
if not so resolved, Bluebird will have the tie-breaking vote, provided that if a Business Combination has occurred with respect to Bluebird, Celgene will have the tie-breaking vote. 

(b) Obligations Under the Collaboration Plan. Each Party will use Commercially Reasonable Efforts to perform (itself or through
its Affiliates or by permitted subcontracting pursuant to Section 2.4) its respective obligations under the Collaboration Plan, and will cooperate with and provide reasonable support to the other Party in such other Party’s performance of
its responsibilities under the Collaboration Plan. The Collaboration Plan will not assign to Celgene, and Bluebird will not request that Celgene perform, any research or Development activity that would require a sublicense under any Bluebird
In-License. If, notwithstanding the foregoing, the Collaboration Plan assigns to Celgene, or Bluebird requests that Celgene perform, any such research or Development activity, Bluebird will be responsible for any and all obligations to its licensors
under any Bluebird In-License that arise out of such research or Development. The Parties acknowledge and agree, however, that no outcome or success is or can be assured and that failure to achieve desired results will not in and of itself
constitute a breach or default of any obligation in this Agreement (notwithstanding the focus of the Collaboration Program described above). 
 (c) Celgene Manufacturing. In the event the Parties mutually agree that, as a part of the Collaboration Program, Celgene will build and operate a cGMP suite for the processing of Product Candidates
which incorporate Vectors and associated Payloads supplied by Bluebird, the 

  
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AS AMENDED. 
  

 
Parties will enter into such additional agreements as may be necessary for Celgene to do so, including a Vector and Payload supply agreement. Prior to or during initial proof of concept studies,
Celgene and Bluebird will mutually assess the capability for sole supply manufacture of Vector Supply, and agree to provisions to ensure the Manufacture and distribution, of Vector Supplies, in adequate quantities, of adequate quality, and in
acceptable timeframes so as to not delay clinical Development and Commercialization of Product Candidates. Multiple sites may be required to supply and store inventories of Vector Supplies. 

(d) Collaboration Program Term. Unless terminated or extended pursuant to the terms hereof, the term of the Collaboration Program
will commence on the Effective Date and continue for an initial period of three (3) years (the “Initial Collaboration Term”). Celgene may elect to extend the Collaboration Program for (i) first, one additional two
(2) year term (the “First Collaboration Extension Term”) and (ii) then next for one additional [***] term (the “Second Collaboration Extension Term”, and together with the Initial Collaboration Term
and the First Collaboration Extension Term, if any, the “Collaboration Program Term”) by providing written notice to Bluebird of such election at least [***] prior to the expiration of the Initial Collaboration Term or First
Collaboration Extension Term, as applicable, and payment of the applicable extension fees set forth in Section 8. Absent further agreement of the Parties, the maximum Collaboration Program Term (assuming Celgene elects both of the foregoing
extensions) is [***]. 
 (e) Relationship. 
 (i) During the Collaboration Program Term, neither Bluebird nor its Affiliates (nor any others on behalf of or with, or under license (including a covenant not to sue) or sublicense from, Bluebird or any
its Affiliates) will research, Develop, Manufacture or commercialize any actual or potential products (including Vectors and associated Payloads) to be used in the Field other than as a part of the Collaboration Program, and other than with respect
to Declined Product Candidates in accordance with Section 5.7. Notwithstanding this Section 2.1(e)(i), if (i) a Business Combination occurs with respect to Bluebird with a Third Party or (ii) Bluebird acquires a Third Party
(including by a merger or consolidation) so that such Third Party becomes an Affiliate over which Bluebird has control (as defined in Section 1.1), or (iii) Bluebird acquires all or substantially all of the assets of a Third Party
(including any subsidiaries or divisions thereof) (each of (i), (ii) and (iii), a “Bluebird Acquisition”), and, in each case, the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such
Third Party or such Third Party’s Affiliates, other than Bluebird and its Affiliates as of the Bluebird Acquisition) (1) already has, or the acquired assets contain, as applicable, a program that existed prior to, or was planned prior to
and is demonstrably to be implemented shortly after, the Bluebird Acquisition or (2) initiates and pursues a new program following such Bluebird Acquisition, in each case that would otherwise violate this Section 2.1(e)(i) (a
“Bluebird Business Program”), then such Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than Bluebird and its Affiliates as of
the Bluebird Acquisition), as applicable, will be permitted to initiate, pursue and continue such Bluebird Business Program after such Bluebird Acquisition and such initiation, pursuit and continuation will not constitute a violation of this
Section 2.1(e)(i); provided that (A) none of the Collaboration IP or other Patents, Materials or Know-How 

  
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AS AMENDED. 
  

 
Controlled by the other Party and, in each case, licensed to Bluebird will be used in the Bluebird Business Program, and (B) the research or Development activities required under this
Agreement will be conducted separately from any research or Development activities directed to such Bluebird Business Program, including the maintenance of separate lab notebooks and records (password-protected to the extent kept on a computer
network) and separate personnel working on each of the activities under this Agreement and the activities covered under such Bluebird Business Program. 
 (ii) [***] 
 (f) Collaboration Know-How and IP. 

(i) Each Party will promptly (and at least on a calendar quarterly basis) disclose to the other Party any Collaboration Know-How
discovered, created, conceived, developed or reduced to practice by or on behalf of such Party, and will provide the other Party such documentation regarding the same as the other Party may reasonably request. 

(ii) Except as set forth in this Section 2.1(f)(ii) and in Section 2.1(f)(iv) below, each Party will solely own all right,
title and interest in and to all Collaboration IP that is discovered, created, conceived, developed or reduced to practice solely by or on behalf of such Party, and all right, title and interest in and to all Collaboration IP will automatically vest
solely in such Party. [***] Each Party agrees to execute such written assignments and confirmations as are necessary to effect the allocation of ownership of Patents, Know-How and Materials as provided in the immediately preceding sentence, and any
Patents, Know-How and Materials addressed by the immediately preceding sentence (other than clause (C)(2)) shall be considered Collaboration IP. [***] 
 (iii) Except as set forth in Section 2.1(f)(iv) below, the Parties will jointly own any and all Collaboration IP that is discovered, created, conceived, developed or reduced to practice jointly by or
on behalf of the Parties. Each Party will have an undivided one-half interest in and to such jointly-owned Collaboration IP. Each Party will exercise its ownership rights in and to such jointly-owned Collaboration IP, including the right to license
and sublicense or otherwise to exploit, transfer or encumber its ownership interest, without an accounting or obligation to, or consent required from, the other Party, but subject to the licenses hereunder and the other terms and conditions of this
Agreement, including Section 2.1(e). At the reasonable written request of a Party, the other Party will in writing grant such consents and confirm that no such accounting is required to effect the foregoing regarding jointly-owned Collaboration
IP. Each Party, for itself and on behalf of its Affiliates, licensees and sublicensees, and employees, subcontractors (subject to Section 2.4), consultants and agents of any of the foregoing, hereby assigns (and to the extent such assignment
can only be made in the future hereby agrees to assign), to the other Party a joint and undivided interest in and to all jointly-owned Collaboration IP. 
 (iv) Notwithstanding the first sentence of Section 2.1(f)(ii) and notwithstanding Section 2.1(f)(iii), but subject to the second sentence of Section 2.1(f)(ii), (A) Celgene will solely
own any Collaboration IP that is an improvement to, or modification or derivative work of, any Celgene IP, and Bluebird, for itself and on behalf of its Affiliates, licensees and sublicensees, and employees, subcontractors (subject to
Section 2.4), consultants 

  
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AS AMENDED. 
  

 
and agents of any of the foregoing, hereby assigns (and to the extent such assignment can only be made in the future hereby agrees to assign), all of its rights, title and interest in such
Collaboration IP to Celgene, and (B) Bluebird will solely own any Collaboration IP that is an improvement to, or modification or derivative work of, any Bluebird IP, and Celgene, for itself and on behalf of its Affiliates, licensees and
sublicensees, and employees, subcontractors (subject to Section 2.4), consultants and agents of any of the foregoing, hereby assigns (and to the extent such assignment can only be made in the future hereby agrees to assign), all of its rights,
title and interest in such Collaboration IP to Bluebird. To the extent that a particular item of Collaboration IP constitutes an improvement to, or modification or derivative work of, both Celgene IP and Bluebird IP, the Parties will jointly own
such particular item of Collaboration IP pursuant to Section 2.1(f)(iii). 
 (v) Inventorship determination for all
Patents worldwide arising from any Know-How or Material discovered, created, conceived, developed or reduced to practice by or on behalf of the Parties under or in connection with this Agreement and thus the ownership thereof will be made in
accordance with applicable United States patent laws. 
 (g) Regulatory. Bluebird will exclusively own the INDs for the
Development of Product Candidates and will, after reasonable consultation with Celgene under the oversight of the JSC: (i) determine the regulatory plans and strategies for Product Candidates, (ii) prepare and file all Regulatory Filings
with respect to Product Candidates, and (iii) be responsible for conducting all meetings with Regulatory Authorities in connection with the Development of Product Candidates, in each case unless and until such time that such Product Candidate
becomes an Optioned Candidate. Bluebird will provide Celgene with reasonable prior notice of all such meetings with Regulatory Authorities, and Celgene will have the right to participate in such meetings. 

(h) Licenses. 
 (i) During the Term, Bluebird hereby grants to Celgene the co-exclusive (with Bluebird and its Affiliates), worldwide, royalty-free right and license in the Field, without the right to grant sublicenses
(other than to permitted subcontractors under Section 2.4), under Collaboration IP solely owned by Bluebird pursuant to Section 2.1(f) and Bluebird’s interest in jointly owned Collaboration IP, in each case solely to conduct research
and Development under the Collaboration Plan as part of the Collaboration Program in accordance with the terms of this Agreement. Except as set forth in Section 12.4(c) or as may be permitted under an applicable Development &
Commercialization Agreement, Celgene will not practice or otherwise use any Collaboration IP solely owned by Bluebird pursuant to Section 2.1(f) other than in accordance with the license granted in this Section 2.1(h)(i). 

(ii) Subject to the terms and conditions of this Agreement, during the Term and thereafter, Celgene hereby grants to Bluebird a
worldwide, fully paid-up, non-exclusive license, with the right to sublicense through multiple tiers, under (A) Collaboration IP solely owned by Celgene pursuant to Section 2.1(f), (B) all improvements to, or modifications or
derivative works of, any Bluebird IP that are discovered, created, conceived, developed or reduced to practice by or on behalf of Celgene or its Affiliates during the Collaboration Program Term in the course of Developing an Optioned Candidate under
a Development & 

  
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AS AMENDED. 
  

 
Commercialization Agreement, and [***], in each case of (A) through (C), that are related to the Manufacture of Vectors, solely to research, Develop, Manufacture and commercialize Vectors,
provided that (w) the foregoing license does not include any Patents and Know-How for Manufacturing (other than Manufacturing of Vectors), (x) [***] (y) during the Term and the term of any applicable Development &
Commercialization Agreement, the foregoing license does not include the right to research, Develop, Manufacture or commercialize any Vectors that are used in connection with Optioned Candidates or Elected Candidates or Licensed Products under such
Development & Commercialization Agreement, other than with and for Celgene, and (z) [***]. Further, the Parties acknowledge and agree that, upon written notice to Celgene, Bluebird may decline the taking of or terminate such sublicense
from Celgene with respect to any Patents, Know-How or Materials that are in-licensed by Celgene pursuant to a Celgene New In-License that is an Applicable Celgene In-License. [***] 

(i) Celgene IP. If either Party desires that Celgene make available any Patents, Know-How or Material Controlled by Celgene or its
Affiliates (other than pursuant to a Celgene In-License, which is governed by Section 4.1(c), and other than Collaboration IP) for use in the Collaboration Program, such Party will notify the JSC and the JSC will discuss whether or not such
Patents, Know-How or Materials would be useful for the Collaboration Program. If the JSC concludes that such Patents, Know-How or Materials would be useful for the Collaboration Program, the JSC will invite Celgene to make such intellectual property
available to the Collaboration Program. Celgene will have sole discretion whether or not to make such intellectual property available to the Collaboration Program, and if Celgene so elects it will make such intellectual property available by
providing the JSC with written notice specifying the Patents, Know-How and/or Materials that will be made available to the Collaboration Program as “Celgene IP”. Except by such written notice provided to the JSC, no Patents, Know-How or
Materials Controlled by Celgene or its Affiliates (other than pursuant to a Celgene In-License, which is governed by Section 4.1(c) and other than Collaboration IP) will be made available for, or used in, the Collaboration Program, and no such
Patents, Know-How or Materials shall be considered “Celgene IP”. 
 2.2 Collaboration Program Expenses. Except
for any amounts that may be payable by Celgene under a Vector and associated Payload supply agreement described in Section 2.1(c), each of Bluebird and Celgene is and will remain solely responsible for all of its internal costs and expenses
that are incurred by or on its behalf in connection with the performance of the Collaboration Plan. Subject to Sections 4.1, 4.2, 8.6 and 9.2, and except for any amounts that may be payable by Celgene under a Vector and associated Payload
supply agreement described in Section 2.1(c) or a Celgene In-License, Bluebird will be responsible for all out-of-pocket costs and expenses payable to Third Parties in connection with the performance of the Collaboration Plan. 

2.3 Collaboration Program Records, Reports and Materials. 
 (a) Records. Each Party will maintain, or cause to be maintained, records of its activities under the Collaboration Program in sufficient detail and in good scientific manner appropriate for
scientific, Patent and regulatory purposes, that will properly reflect all work included in the Collaboration Program, for a period of at least ten (10) years after the creation of such records, but in no event less than required by applicable
Laws. Each Party will have the right to request and receive a copy of any such records. 

  
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AS AMENDED. 
  

 (b) Collaboration Program Reports. Each Party will furnish
to the JSC a high-level summary written report within thirty (30) days after each June 30th and December 31st occurring during the Collaboration Program Term, describing its progress under the Collaboration Plan as part of the Collaboration Program during the previous six (6) month period. Each Party agrees
that it will promptly respond to the other Party’s reasonable questions regarding any of such Party’s reports. 
 (c)
Materials. 
 (i) Each Party will, during the Collaboration Program Term, as a matter of course as described in the
Collaboration Plan or upon the other Party’s reasonable written request, furnish to each other samples of Materials that are in such Party’s Control and are necessary for the other Party to carry out its responsibilities under the
Collaboration Plan, provided that, prior to Celgene providing any Materials to Bluebird, Celgene will notify Bluebird of the cost of such Materials and Bluebird may elect whether or not to receive such Materials from Celgene. Subject to the
foregoing, after Celgene has provided Materials costing more than [***], Bluebird will reimburse Celgene for the costs of any additional Materials. 
 (ii) Each Party will use such Materials only in accordance with the Collaboration Plan and otherwise in accordance with the terms and conditions of this Agreement and any instructions provided by the
Party furnishing the Materials. Except with the prior written consent of the supplying Party (such consent not to be unreasonably withheld, delayed or conditioned), the Party receiving any Materials will not distribute or otherwise allow the release
of Materials to any Affiliate (other than wholly-owned subsidiaries) or Third Party, except for subcontracting as permitted hereunder. All Materials delivered to the receiving Party will remain the sole property of the supplying Party and will be
used in compliance with all applicable Law. The Materials supplied under this Agreement will be used with prudence and appropriate caution in any experimental work because not all of their characteristics may be known. 

2.4 Permitted Subcontracting. Each Party may subcontract any of its activities to be performed under the Collaboration Plan to an
Affiliate or Third Party, provided that any such Affiliate or Third Party will have entered into a written agreement with such Party that includes terms and conditions protecting and limiting use and disclosure of Confidential Information and
Materials and Know-How at least to the same extent as under this Agreement, and requiring such Affiliate or Third Party and its personnel to assign to such Party all right, title and interest in and to any Patents, Know-How and Materials created,
conceived or developed in connection with the performance of subcontracted activities to the extent required to research, Develop, Manufacture and commercialize Product Candidates, provided that with respect to Third Parties that are academic or
other non-commercial Persons, a Party will be required only to use commercially reasonable efforts to obtain such assignment, and in the absence of such assignment, the Parties will mutually agree on the rights (e.g., a license or option to
license) to be obtained from such academic or non-commercial Persons. Any such subcontracting activities will be described in the reports for the Collaboration Program required by Section 2.3(b). 

  
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AS AMENDED. 
  

	3.	Governance. 

 3.1
Management. Management of the Collaboration Program activities will be under the responsibility of one person to be designated by Celgene (the “Celgene Program Director”) and one person to be designated by Bluebird
(the “Bluebird Program Director,” and together with the Celgene Program Director, the “Program Directors”). 
 3.2 Joint Steering Committee. 
 (a) Steering Committee. As soon as
practicable (but not later than sixty (60) days) following the Effective Date, the Parties will establish a Joint Steering Committee, comprised of three (3) representatives of Bluebird and three (3) representatives of Celgene
(the “JSC”). Each Party may replace its representatives on the JSC or its Program Director at any time upon written notice to the other Party. With the consent of the other Party (such consent not to be unreasonably withheld,
delayed or conditioned), each Party may invite non-voting employees and consultants to attend meetings of the JSC, subject to their agreement to be bound to the same extent as a permitted subcontractor under Section 2.4. 

(b) Meetings. While in existence, the JSC will meet each calendar quarter and, at a minimum, two (2) of such meetings each
calendar year starting in 2013 will be in person (which in-person meeting will be held at locations mutually agreed by the Parties). Meetings of the JSC will be effective only if at least one (1) representative of each Party is present or
participating. Each Party will be responsible for all of its own expenses of participating in the meetings. The Parties will endeavor to schedule meetings of the JSC at least six (6) months in advance. Bluebird will prepare and circulate a
meeting agenda prior to each such meeting. The Parties will alternate in preparing written minutes of such meeting, and the preparing Party will circulate such minutes within fifteen (15) days after such meeting. The Parties will agree on the
minutes of each meeting promptly, but in no event later than the next meeting of the JSC. 
 (c) Responsibilities. The
JSC will oversee and supervise the overall performance of the Collaboration Plan and within such scope will: 
 (i)
Periodically review the Parties’ efforts and progress under the Collaboration Plan; 
 (ii) Review the Collaboration
Program; 
 (iii) Review any proposed modifications or amendments to the Collaboration Plan and the Collaboration Program;

 (iv) Prioritize and oversee execution of specific activities to be performed under the Collaboration Plan and the
Collaboration Program; 
 (v) Review Patent Committee advice with regard to scientific activities to be performed under the
Collaboration Plan and the Collaboration Program; 
 (vi) Review Collaboration Program Advisory Committee advice with regard to
scientific activities to be performed under the Collaboration Plan and the Collaboration Program; 
 (vii) Review and select
Product Candidates for additional work as part of the Collaboration Program; 

  
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AS AMENDED. 
  

 (viii) Review and evaluate Product Candidates for which Development work should be
performed as part of the Collaboration Program; 
 (ix) Review and approve of the regulatory plans and strategies for Product
Candidates; 
 (x) Review all Regulatory Filings with respect to Product Candidates; 

(xi) Form such other committees (“Sub-Committees”) as the JSC may deem appropriate. As soon as practicable (but not
later than sixty (60) days) after the Effective Date, the Parties will establish a Sub-Committee comprised of three (3) representatives of Celgene, three (3) representatives of Bluebird, and Dr. Malcolm K. Brenner (the
“Collaboration Program Advisory Committee”). The Collaboration Program Advisory Committee will monitor and advise the Parties on the conduct and progress of the Collaboration Program. Each Party may replace its representatives on
the Collaboration Program Advisory Committee at any time upon written notice to the other Party. Any such Sub-Committee (including the Collaboration Program Advisory Committee) may make recommendations to the JSC but may not be delegated JSC
decision-making authority; 
 (xii) Address such other matters relating to the activities of the Parties under this Agreement
as either Party may bring before the JSC, including any matters that are expressly for the JSC to decide as provided in this Agreement; and 
 (xiii) Attempt to resolve any disputes on an informal basis. 
 (d)
Decision-making. The three (3) JSC representatives of each Party will collectively have one (1) vote, and the JSC will make decisions only by unanimous consent in the sole discretion of each Party with respect to its vote. [***]

 (e) Limits on JSC Authority. Each Party will retain the rights, powers and discretion granted to it under this
Agreement and no such rights, powers, or discretion will be delegated to or vested in the JSC unless such delegation or vesting of rights is expressly provided for in this Agreement or the Parties expressly so agree in writing. The JSC will not have
the power to, nor will the Party having the tie-breaking vote in the JSC have the power to (i) amend, modify or waive compliance with this Agreement (other than as expressly permitted hereunder), (ii) alter, increase or expand the
Parties’ rights or obligations under this Agreement, (iii) determine that a Party has fulfilled any obligations under this Agreement or that a Party has breached any obligation under this Agreement, (iv) make a decision that is
expressly stated to require the mutual agreement of the Parties, (v) amend or modify the Collaboration Plan, (vi) change the Collaboration Program in any manner that would alter the fundamental objectives of the Collaboration Program as
generally described in Section 2.1(a), or (vi) determine that milestone events required for the payment of milestone payments have or have not occurred. 
 (f) Term. The JSC and any subcommittees thereof will cease to exist three (3) months after the end of the Collaboration Program Term. 

3.3 Patent Committee. 
 (a) Promptly (but no later than sixty (60) days) after the Effective Date, the Parties will (i) each designate representative(s) to consult with the other Party’s representative(s) with

  
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AS AMENDED. 
  

 
respect to Patent ownership, Prosecution and Maintenance, enforcement and defense matters (the “Patent Liaisons”), and (ii) establish a patent committee (the “Patent
Committee”). The purpose of the Patent Committee is to determine ownership of intellectual property, and facilitate the discussion and coordination of Prosecution and Maintenance, enforcement and defense matters, in accordance with and
subject to the terms of this Agreement. The Patent Liaisons will be the primary point of contact for the Parties regarding the foregoing activities and will facilitate all such activities hereunder, including preparing and finalizing minutes of the
Patent Committee and will be responsible for assisting the Patent Committee in performing its oversight responsibilities. 
 (b)
Decisions. All decisions of the Patent Committee will be made by consensus, with each Party having one vote. If the Patent Committee cannot agree on a matter within the Patent Committee’s authority within five (5) days after it has
met and attempted to reach such decision, then, either Party may, by written notice to the other, have such issue referred to the Program Directors for resolution. The Parties’ respective Program Directors will meet within five (5) days
after such matter is referred to them, and will negotiate in good faith to resolve the matter. If the Program Directors are unable to resolve the matter within five (5) days after the matter is referred to them, then the decision will be
resolved as set forth below: 
 (i) IP Ownership. The Patent Committee will determine ownership of Collaboration IP in
accordance with and subject to the terms of Section 2.1(f); provided that the Patent Committee may allocate ownership of a particular item of intellectual property to improve the prospects of obtaining patent protection with respect to such
item of intellectual property, even if such allocation is not in accordance with the terms of Section 2.1(f), so long as the Parties mutually agree to such allocation. In the event the Patent Committee cannot agree on a matter regarding
ownership of an item of intellectual property, and the Program Directors are unable to resolve such matter, then such dispute will be resolved by a Third Party patent counsel selected by the Patent Committee who (and whose firm) is not, and was not
at any time during the five (5) years prior to such dispute, an employee, consultant, legal advisor, officer, director or stockholder of, and does not have any conflict of interest with respect to, either Party. Such patent counsel will
determine ownership of such intellectual property in accordance with U.S. patent law and Section 2.1(f). Expenses of the patent counsel will be shared equally by the Parties. 

(ii) Patent Prosecution. The Patent Committee will discuss material issues and provide input to each other regarding the
Prosecution and Maintenance, enforcement and defense of Bluebird IP, Celgene IP and jointly owned Collaboration IP. The Patent Liaisons will be responsible for coordinating the implementation of each Party’s strategies for the protection of the
foregoing intellectual property rights related to Product Candidates. All final decisions related to the Prosecution and Maintenance, enforcement or defense of any Bluebird IP, Celgene IP and jointly-owned Collaboration IP will be made by the Party
with the right to control such Prosecution and Maintenance, enforcement or defense, as applicable, as set forth in Section 9. 

  
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AS AMENDED. 
  

	4.	Third Party Licenses. 

 4.1 New Licenses. 
 (a) Identification. [***] 

(b) Bluebird Contribution to the Collaboration. [***] 
 (e) Celgene Applicable/New In-Licenses. With respect to each Applicable Celgene In-License that is a Celgene New In-License: 

(i) Celgene will be solely responsible for any upfront payment payable to the licensor under such Applicable Celgene In-License.

 (ii) Except as provided in Sections 2.1(h)(ii), 5.7 and 12.4, Celgene and Bluebird will each be responsible for [***] any
other payments required to be paid to the licensor under such Applicable Celgene In-License in respect of Collaboration Program activities or the research, Development, Manufacture or commercialization of Product Candidates, but excluding any
payments that are (a) triggered by the grant of a sublicense under the Applicable Celgene In-License (other than sublicenses granted by Bluebird or its sublicensees), (b) annual fees paid to maintain the Applicable Celgene In-License in
effect, (c) Patent Costs, (d) any payments that are royalty payments (including sales-based milestone payments), and (e) payments resulting from Celgene’s breach of the Applicable Celgene In-License not attributable to Bluebird
or its contract Third Parties or sublicensees, which excluded payments will be the sole responsibility of Celgene; provided that Bluebird’s [***] share of such payments will become due and payable upon the execution of the first
Development & Commercialization Agreement, and will be paid as follows: [***] 
 (iii) Any payments that are royalties
payable by Celgene or its Affiliates under the Applicable Celgene In-License will be subject to Section 4.3(d) of such License Agreement or Section 11.3(d) of any Co-Development, Co-Promote and Profit Share Agreement, as applicable.

 (f) Celgene Pre-Existing/Applicable In-Licenses. With respect to any Applicable Celgene In-License that is a Celgene
Pre-Existing In-License, except as provided in Sections 2.1(h)(ii), 5.7 and 12.4, Celgene will be solely responsible for all payments required to be paid to the licensor under such Applicable Celgene In-License, and any payments that are royalties
payable by Celgene or its Affiliates under the Applicable Celgene In-License will be subject to Section 4.3(d) of such License Agreement or Section 11.3(d) of any Co-Development, Co-Promote and Profit Share Agreement, as applicable.

 4.2 Product Candidate In-Licenses. Other than with respect to Baylor as contemplated by the Baylor Agreements, which
are governed by Sections 4.5 and 5.5 hereof, in the event that the Parties desire to enter into an agreement with any Third Party to obtain rights to Patents, Know-How or Materials that would constitute solely a new Product Candidate (if developed
pursuant to this Agreement) in the Field, as opposed to only being necessary or useful for supporting research, Development or Commercialization of existing Product Candidates (a “Product Candidate In-License”), the Parties will
jointly determine a strategy for endeavoring to procure rights under such Patents, Know-How or Materials, including with respect to allocation of the Parties’ responsibilities for any payments that may become due during the Collaboration
Program Term under such Product Candidate In-License. Any such Product Candidate 

  
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AS AMENDED. 
  

 
In-License addressing any such new Product Candidate will require the prior written approval of both Parties, will be with both Parties and will be committed to the Collaboration Program (and not
the Parties on an individual basis). Accordingly, any product candidate in-licensed pursuant to a Product Candidate In-License will be a “Product Candidate” hereunder, and will only be Developed or commercialized by either Party as a part
of the Collaboration Program or under an executed Development and Commercialization Agreement, unless and until such Product Candidate becomes a Declined Product Candidate in accordance with Section 5.7. If the Parties agree that any Patents,
Know-How or Materials in-licensed under a Product Candidate In-License will be used to Develop and commercialize a Product Candidate under a Development and Commercialization Agreement, the Parties will discuss in good faith and agree on the
allocation of the Parties’ applicable rights and obligations thereto, including with respect to amounts payable under such Product Candidate In-License (other than a Baylor Product License), which terms will be set forth in such Development and
Commercialization Agreement. If an in-license from a Third Party of rights to Patents, Materials or Know-How that would constitute a new Product Candidate also includes other rights that potentially have broader applicability (e.g., that may be
useful for supporting research, Development or commercialization of Product Candidates that are against Target Antigens different than the Target Antigen in the Product Candidate in such Third Party in-license), such in-license will be treated as a
“Product Candidate In-License” hereunder and the Parties will discuss in good faith the allocation of such other rights and obligations, along with costs, in accordance with the principles set forth in Section 4.1 and this
Section 4.2. The Parties acknowledge that the terms of this Section 4.2 may need to be discussed and modified with respect to any particular Product Candidate In-License (other than a Baylor Product License) depending on the then existing
facts and circumstances relating to such Product Candidate In-License. 
 4.3 Maintenance of Bluebird In-Licenses.
Bluebird (i) will duly perform and observe all of its obligations under the Bluebird In-Licenses in all material respects and maintain in full force and effect the Bluebird In-Licenses, and (ii) will not, without Celgene’s prior
written consent (such consent not to be unreasonably withheld, conditioned or delayed), (a) amend, modify, restate, cancel, supplement or waive any provision of any Bluebird In-License, or grant any consent thereunder, or agree to do any of the
foregoing, or (a) exercise any right to terminate any Bluebird In-License, in each case ((a) and (b)) that would reasonably be expected to adversely affect in any respect the rights of Celgene under this Agreement or any potential or executed
Development & Commercialization Agreement. Bluebird will provide Celgene with written notice as promptly as practicable (and in any event within five (5) business days) after becoming aware of any of the following: (1) any
material breach or default by Bluebird or any of its Affiliates of any covenant, agreement or other provision of any Bluebird In-License, (2) any notice or claim from the counterparty to any Bluebird In-License terminating or providing notice
of termination of any Bluebird In-License, (3) any notice or claim alleging any breach of default under any Bluebird In-License, or (4) the existence of any facts, circumstances or events which alone or together with other facts,
circumstances or events would reasonably be expected (with or without the giving of notice or passage of time or both) to give rise to a breach of or default under or right to terminate any Bluebird In-License. If Bluebird fails to pay any amounts
due under any Bluebird In-License and if such nonpayment would permit the counterparty to such Bluebird In-License to terminate or suspend the same or any rights thereunder, Celgene will have 

  
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AS AMENDED. 
  

 
the right, but not the obligation, in its sole discretion, to pay such amounts on Bluebird’s behalf, and any amounts so paid by Celgene may be taken by Celgene as a credit against any
amounts payable to Bluebird under this Agreement or any Development & Commercialization Agreement. 
 4.4 [***]

 4.6 No Implied Rights. No license, sublicense or other right is or will be created or granted hereunder by
implication, estoppel or otherwise. Any licenses, sublicenses or rights will be granted only as expressly provided in this Agreement or any executed Development & Commercialization Agreement. 

 

	5.	Option for Licensed Candidates. 

 5.1 Option Period. Bluebird will provide Celgene with all safety and efficacy data generated with respect to a Product Candidate in an initial Phase 1 Study and all correspondence to and from any
Regulatory Authority regarding such Product Candidate (collectively, “Phase 1 Study Data”), as soon as reasonably practicable following Bluebird’s receipt of same. From the period commencing at the Effective Date and ending, on
a Product Candidate-by-Product Candidate basis, [***] following the completion of an initial Phase 1 Study with respect to such Product Candidate (the “Celgene Option Period”), Celgene will have the exclusive option to take a
license to each Product Candidate, provided that if Celgene reasonably requests any additional data or information for such Product Candidate within the Celgene Option Period set forth above, the Celgene Option Period will be extended for an
additional [***] after Celgene’s receipt of such additional data or information. Bluebird shall deliver to Celgene no later than [***] following the completion of an initial Phase 1 Study with respect to such Product Candidate, the Schedule
referred to in Section 16.2 of the Co-Development, Co-Promote and Profit Share Agreement or Section 9.2 of the License Agreement. Celgene may exercise such option by providing to Bluebird, prior to the expiration of the Celgene Option
Period, (i) written notice that a Product Candidate is selected by Celgene to be an Optioned Candidate hereunder, and (ii) the additional information set forth in Exhibit F (collectively, the “Celgene Option
Notice”). A separate Celgene Option Notice and Initial Option Fee will be required for each Product Candidate optioned by Celgene pursuant to this Section 5.1, and Celgene will pay to Bluebird the Initial Option Fee for each such
Optioned Candidate as set forth in Section 8.4. Subject to Section 5.7 and Section 12.4, if not exercised prior to the expiration of the Celgene Option Period, the option and other rights granted to Celgene under this Section 5
with respect to a Product Candidate will terminate in full and will no longer be exercisable. 
 5.2 Celgene’s Exercise
of Option. Within [***] of Celgene’s delivery of a Celgene Option Notice to Bluebird, Celgene (or an Affiliate designated by Celgene) and Bluebird will enter into a License Agreement in the form attached hereto as Exhibit A with
respect to such Optioned Candidate (updating the appendices thereto), modified, if appropriate, as provided in Sections 4.2 or 5.5, and subject to Section 5.9. Upon execution of such License Agreement, such Optioned Candidate will be an
“Elected Candidate” thereunder. 
 5.3 Co-Promotion/Co-Development Option Exercise. Within [***] following
Celgene’s delivery of a Celgene Option Notice to Bluebird, and subject to Section 5.9, Bluebird may exercise an option, by delivery of written notice to Celgene (the “Bluebird Option Notice”) to

  
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AS AMENDED. 
  

 
co-promote and co-Develop the Optioned Candidate in the U.S. as set forth in the Co-Development, Co-Promote and Profit Share Agreement attached hereto as Exhibit B, provided that with
respect to a Baylor-Only Candidate for which Celgene has delivered a Celgene Option Notice, such option will end on the earlier of (i) [***] following Celgene’s commencement of a Pivotal Study (as defined in the License Agreement) for such
Baylor-Only Candidate, and (ii) the date that Bluebird delivers written notice to Celgene that Bluebird is declining to exercise such option. Prior to the expiration of such option for a Baylor-Only Candidate, upon Bluebird’s written
request, Celgene will provide Bluebird with (a) a reasonably detailed accounting of any payments made or other actions taken by Celgene pursuant to the License Agreement executed pursuant to Section 5.2 that would be the responsibility of
Bluebird under the Co-Development, Co-Promote and Profit Share Agreement, including, for avoidance of doubt, costs incurred by Celgene in Developing such Baylor-Only Candidate through and including the Pivotal Study for such Baylor-Only Candidate,
and (b) all safety and efficacy data in Celgene’s possession as of the date of such request generated with respect to such Baylor-Only Candidate in all clinical studies conducted by Celgene for such Baylor-Only Candidate, all
correspondence to and from any Regulatory Authority in Celgene’s possession as of the date of such request regarding such Baylor-Only Candidate, and any other information relating to such Baylor-Only Candidate reasonably requested by Bluebird
and in Celgene’s possession as of the date of such request. In the event that Bluebird exercises such option, the Parties will promptly, but in any event within [***], terminate the License Agreement executed pursuant to Section 5.2 with
respect to such Optioned Candidate, and enter into a Co-Development, Co-Promote and Profit Share Agreement in the form attached hereto as Exhibit B with respect to such Optioned Candidate, with appropriate amendments to reflect and
reimburse Celgene for any payments made or other actions taken by Celgene pursuant to the License Agreement executed pursuant to Section 5.2 that are the responsibility of Bluebird under the Co-Development, Co-Promote and Profit Share
Agreement, including, for avoidance of doubt, costs incurred by Celgene in Developing a Baylor-Only Candidate through and including the Pivotal Study for the Baylor-Only Candidate. Upon execution of such Co-Development, Co-Promote and Profit Share
Agreement, such Optioned Candidate will be an “Elected Candidate” thereunder. [***] 
 5.4
Non-Co-Promotion/Co-Development Option Exercise. If during the [***] following Celgene’s delivery of a Celgene Option Notice to Bluebird, Bluebird notifies Celgene in writing that Bluebird will not exercise the option set forth above in
Section 5.3, or Bluebird does not deliver a Bluebird Option Notice to Celgene prior to the expiration of the [***] period following Celgene’s delivery of a Celgene Option Notice to Bluebird, Celgene will pay to Bluebird the Additional
Option Fee as set forth in Section 8.5, subject to Section 5.5. 
 5.5 Baylor-Only Candidate Royalty &
Milestone Payments. In the event that any Optioned Candidate is also a Baylor-Only Candidate (as reasonably determined by the Parties), (i) the Initial Option Fee and the Additional Option Fee will each be reduced [***], and (ii) any
royalties or milestone payments payable under the applicable Development & Commercialization Agreement with respect to such Optioned Candidate will be reduced [***]. All such payments will become due and payable only upon the commencement
of a Pivotal Study (as defined in the applicable Development & Commercialization Agreement) for such Optioned Candidate. At such time that the Optioned Candidate no longer satisfies all of the requirements of the definition of Baylor-Only
Candidate as set forth below in this Section 5.5, all 

  
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AS AMENDED. 
  

 
future milestone and royalty payments thereunder will be payable in the original amounts thereunder [***]. For clarity, such [***] reduction will only apply to royalties and milestone payments
and no other payments under the applicable Development & Commercialization Agreement (and for clarity, in the Co-Development, Co-Promote and Profit Share Agreement attached hereto as Exhibit B, the profit share/loss will be
unaffected). [***] 
 5.6 Follow-On Product Candidates. The Parties acknowledge and agree that the Collaboration Program
may include the Development and evaluation of multiple Product Candidates targeting the same Target Antigen. If Celgene exercises its option pursuant to Section 5.1 to take a license to a Product Candidate that targets the same Target Antigen
as an existing Optioned Candidate (a “Follow-On Product Candidate”), then the Parties will enter into a new License Agreement in the form attached hereto as Exhibit A with respect to such Follow-On Product Candidate,
unless (i) Bluebird has exercised or does exercise its option to co-promote and co-Develop such existing Optioned Candidate in the U.S. as set forth in Section 5.3, and (ii) this Agreement has not been terminated by Celgene pursuant
to Section 12.3(a), in which case the Parties will enter into a Co-Development, Co-Promote and Profit Share Agreement with respect to such Follow-On Product Candidate, provided that no [***] will be payable under any such Development &
Commercialization Agreement. If the Parties enter into Co-Development, Co-Promote and Profit Share Agreement with respect to such Follow-On Product Candidate, Bluebird will have the option of paying [***] Bluebird’s allowable expenses
thereunder by [***]. If the Parties enter into a License Agreement pursuant to this Section 5.6 with respect to a Follow-On Product Candidate, Celgene will pay to Bluebird (a) the Initial Option Fee in accordance with Section 8.4, and
(b) the Additional Option Fee in accordance with Section 8.5 (but excluding subsections (i) and (ii) of such Section 8.5). If the Parties enter into a Co-Development, Co-Promote and Profit Share Agreement pursuant to this
Section 5.6 with respect to a Follow-On Product Candidate, Celgene will pay to Bluebird the Initial Option Fee in accordance with Section 8.4 but no Additional Option Fee. 

5.7 Declined Product Candidates. 
 (a) Bluebird Development. If Celgene does not exercise its option with respect to a Product Candidate as set forth in Section 5.1, such Product Candidate or IND Product Candidate, as
applicable, will become a “Declined Product Candidate” hereunder. Bluebird will have the option, exercisable upon written notice to Celgene (a “Bluebird Development Notice”), to Develop such Declined Product
Candidate outside of the scope of the Collaboration Program, and Celgene hereby grants to Bluebird an exclusive, worldwide, royalty-free right and license, with the right to grant sublicenses, under the Celgene IP and Celgene’s interest in
jointly owned Collaboration IP, solely to Develop such Declined Product Candidate. [***] In connection with any such Development activities, Bluebird will (i) maintain, or cause to be maintained, records of its activities with respect to the
Development of such Declined Product Candidate in sufficient detail and in good scientific manner appropriate for scientific, Patent and regulatory purposes, for a period of at least ten (10) years after the creation of such records, but in no
event less than required by applicable Laws, and Celgene will have the right to request and receive a copy of any such records, and (ii) furnish Celgene with a copy of any safety and efficacy data generated by Bluebird or its Affiliates in
connection with a clinical trial performed with respect to such Declined Product Candidate, and all correspondence to and from any Regulatory Authority regarding such Declined Product Candidate, at least thirty (30) days prior to initiating a
Declined Product Candidate Study for such Declined Product Candidate. 

  
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AS AMENDED. 
  

 (b) Celgene Buy-In Rights. 

(i) At least thirty (30) days prior to initiating a Declined Product Candidate Study for a Declined Product Candidate, and no later
than thirty (30) days after completing a Declined Product Candidate Study for a Declined Product Candidate, Bluebird will provide Celgene with written notice of same. Celgene will have the option, exercisable on a Declined Product
Candidate-by-Declined Product Candidate basis at any time prior to [***] completion of a Declined Product Candidate Study for such Declined Product Candidate, to designate such Declined Product Candidate as an Optioned Candidate. [***] prior to the
initiation of a Declined Product Candidate Study for a Declined Product Candidate, Bluebird will provide to Celgene (1) all safety and efficacy data in Bluebird’s possession as of the date of such disclosure generated with respect to such
Declined Product Candidate in all clinical studies conducted prior to the Declined Product Candidate Study for such Declined Product Candidate, and (2) all correspondence to and from any Regulatory Authority regarding such Declined Product
Candidate as of the date of such disclosure. Following such disclosure, Bluebird will provide Celgene with (x) any additional data and correspondence described in subsections (1) and (2) that comes into Bluebird’s possession
during such [***] period, and (y) any other information relating to such Declined Product Candidate reasonably requested by Celgene. Within [***] after the completion of a Declined Product Candidate Study for a Declined Product Candidate,
Bluebird will provide Celgene with all safety and efficacy data generated with respect to such Declined Product Candidate in such Declined Product Candidate Study, all correspondence to and from any Regulatory Authority regarding such Declined
Product Candidate, and any other information relating to such Declined Product Candidate reasonably requested by Celgene. 

(ii) Such option is exercisable by Celgene by providing Bluebird with a Celgene Option Notice, and if Celgene so elects, (1) such
Declined Product Candidate will be an Optioned Candidate for all purposes hereunder (other than Section 5.1), and (2) Celgene will pay to Bluebird (in lieu of any Option Fees) an amount equal to: 

(A) if the option is exercised by Celgene prior to the initiation of the Declined Product Candidate Study, the greater of [***]; or

 (B) if the option is exercised by Celgene after the initiation of the Declined Product Candidate Study, the greater of
[***]. 
 (iii) If Celgene does not exercise its option with respect to a Declined Product Candidate as set forth above,
(A) the Development license granted by Celgene to Bluebird under Section 5.7(a) will also include the rights to Manufacture and commercialize such Declined Product Candidate, provided that such license shall be limited to the Celgene IP
and jointly owned Collaboration IP as it exists at the time Celgene’s option to the Declined Product Candidate has expired or been terminated (including in each case any additions, divisions, continuations, continuations-in-part, invention
certificates, substitutions, reissues, reexaminations, extensions, registrations, supplementary protection certificates and renewals of such Celgene IP and Joint Collaboration IP), (B) such Declined Product Candidate will continue to be
excluded from the scope of the Collaboration Program, (C) Bluebird will reimburse 

  
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AS AMENDED. 
  

 
Celgene within ten (10) days of the expiration of Celgene’s option for the Declined Product Candidate for any royalty, milestone or other payments made by Celgene under the Applicable
Celgene In-License (other than any upfront payment) in respect of such Declined Product Candidate; (D) if any royalty, milestone or other payment becomes due under any Applicable Celgene In-License that is attributable to Bluebird as a
sublicensee (together with its licensees and their respective Affiliates) thereunder with respect to such Development, Manufacture or commercialization of the Declined Product Candidate, Celgene will pay same, provided that Bluebird will reimburse
Celgene for any such payment within thirty (30) days of Bluebird’s receipt of Celgene’s written invoice therefor, and Bluebird’s failure to pay such reimbursement within such time period will entitle Celgene to terminate
Bluebird’s sublicense under the Applicable Celgene In-License upon thirty (30) days written notice; and (E) subject to the exclusivity restrictions set forth in Section 2.1(e), Section 3.5 of the License Agreement (if
applicable) or Section 10.4 of the Co-Development, Co-Promote and Profit Share Agreement (if applicable), Bluebird will be free to research, Develop, Manufacture and commercialize such Declined Product Candidate alone or with others with no
further obligation to Celgene other than with respect to any payment that may become due under any Applicable Celgene In-License that is attributable to Bluebird as a sublicensee (together with its licensees and their respective Affiliates)
thereunder with respect to such Development, Manufacture and commercialization. 
 5.8 Bluebird In-Licenses. Any
Pre-Existing In-Licenses that are necessary or useful for a Product Candidate under a Development & Commercialization Agreement will automatically be included within the definition of Applicable Pre-Existing In-Licenses in such
Development & Commercialization Agreement, and any Bluebird Collaboration In-Licenses that Celgene elects to include within the definition of Applicable New In-Licenses in such Development & Commercialization Agreement will be so
included. Any Bluebird Collaboration In-Licenses that Celgene does not elect to include in such Development & Commercialization Agreement will be an Other In-License with respect to such Development & Commercialization Agreement
unless and until Celgene elects to convert such Other In-License to an Applicable New In-License in accordance with the terms of the applicable Development & Commercialization Agreement. Promptly following Celgene’s delivery of a
Celgene Option Notice with respect to a Product Candidate, the Parties will mutually update the applicable Appendices to the Development & Commercialization Agreement. If the Parties cannot agree on such update, Celgene will have the right
to make the final decision with respect to such update. For clarity, if, (1) during the Collaboration Program Term or (2) at the time Celgene takes rights to an IND Candidate or Pre-IND Candidate under Section 12.4, Celgene elects to
convert a Bluebird New In-License into a Bluebird Collaboration In-License pursuant to Section 4.1(d), such Collaboration In-License will be an “Other In-License” with respect to any Development & Commercialization Agreement
in effect or to be entered into under Section 12.4 at the time of such election, and Celgene may elect to convert such Other In-License to an Applicable New In-License in accordance with the terms of such applicable Development &
Commercialization Agreement. 
 5.9 Government Approvals. 

(a) Each of Celgene and Bluebird shall use its commercially reasonable good faith efforts to eliminate any concern on the part of any
court or government authority regarding the 

  
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AS AMENDED. 
  

 
legality of any proposed Development & Commercialization Agreement (including with respect to IND Candidates and Pre-IND Candidates under Section 12.4), including, if required by
federal or state antitrust authorities, promptly taking all steps to secure government antitrust clearance, including cooperating in good faith with any government investigation including the prompt production of documents and information demanded
by a second request for documents and of witnesses if requested. Notwithstanding anything to the contrary in this Agreement, this Section 5.9 and the term “commercially reasonable good faith efforts” do not require that either
Party (i) offer, negotiate, commit to or effect, by consent decree, hold separate order, trust or otherwise, the sale, divestiture, license or other disposition of any capital stock, assets, rights, products or businesses of Celgene, Bluebird
or their respective Affiliates, (ii) agree to any restrictions on the businesses of Celgene, Bluebird or their respective Affiliates, or (iii) pay any material amount or take any other action to prevent, effect the dissolution of, vacate,
or lift any decree, order, judgment, injunction, temporary restraining order, or other order in any suit or proceeding that would otherwise have the effect of preventing or delaying the transactions contemplated by any proposed Development and
Commercialization Agreement. 
 (b) Each of Celgene and Bluebird shall, within ten (10) business days after the execution
of a Development & Commercialization Agreement (or such later time as may be agreed to in writing by the Parties) file with the United States of America Federal Trade Commission (“FTC”) and the Antitrust Division of the
United States of America Department of Justice (“DOJ”) any HSR Filing required of it under the HSR Act in the reasonable opinion of either Party with respect to the transactions contemplated by such Development and Commercialization
Agreement. The Parties shall cooperate with one another to the extent necessary in the preparation of any such HSR Filing. [***] In the event that the Parties make an HSR Filing under this Section 5.9, the relevant Development &
Commercialization Agreement shall terminate (i) at the election of either Party, immediately upon notice to the other Party, in the event that the United States of America Federal Trade Commission or the United States of America Department of
Justice obtains a preliminary injunction under the HSR Act against the Parties to enjoin the transactions contemplated by such Development & Commercialization Agreement or (ii) at the election of either Party, immediately upon notice
to the other Party, in the event that the HSR Clearance Date shall not have occurred on or prior to one hundred eighty (180) days after the effective date of the HSR Filing. Notwithstanding anything to the contrary contained herein, except for
the terms and conditions of this Section 5.9, none of the terms and conditions contained in a Development and Commercialization Agreement shall be effective until the “Implementation Date,” which is agreed and understood to
mean the later of (1) the execution date of the Development & Commercialization Agreement, (2) if a determination is made pursuant to this Section 5.9 that a notification of this Agreement is not required to be made under the
HSR Act, the date of such determination, or (3) if notification of this Agreement is required to be made under the HSR Act, the HSR Clearance Date. As used herein: (x) “HSR Act” means the Hart-Scott-Rodino Antitrust
Improvements Act of 1976, as amended, and the rules and regulations promulgated thereunder; (y) “HSR Clearance Date” means the earliest date on which the Parties have actual knowledge that all applicable waiting periods under
the HSR Act with respect to the transactions contemplated by a Development & Commercialization Agreement have expired or have been terminated; and (z) “HSR Filing” means a filing by Celgene and Bluebird with the United
States of America Federal Trade Commission and the 

  
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AS AMENDED. 
  

 
Antitrust Division of the United States of America Department of Justice of a Notification and Report Form for Certain Mergers and Acquisitions (as that term is defined in the HSR Act) with
respect to the matters set forth in this Agreement, together with all required documentary attachments thereto. 
 (c) Each of
Celgene and Bluebird shall, in connection with any HSR Filing, (i) reasonably cooperate with each other in connection with any communication, filing or submission and in connection with any investigation or other inquiry, including any
proceeding initiated by a private party; (ii) keep the other Party and/or its counsel informed of any communication received by such Party from, or given by such Party to, the FTC, the DOJ or any other U.S. or other governmental authority and
of any communication received or given in connection with any proceeding by a private party, in each case regarding the transactions contemplated by any proposed Development & Commercialization Agreement; (iii) consult with each other
in advance of any meeting or conference with the FTC, the DOJ or any other governmental authority or, in connection with any proceeding by a private party, with any other person, and to the extent permitted by the FTC, the DOJ or such other
governmental authority or other person, give the other Parties and/or their counsel the opportunity to attend and participate in such meetings and conferences; and (iv) permit the other Parties and/or their counsel to review in advance any
submission, filing or communication (and documents submitted therewith) intended to be given by it to the FTC, the DOJ or any other governmental authority; provided, that materials may be redacted to remove references concerning the valuation
of the business of Bluebird. Bluebird and Celgene, as each deems advisable and necessary, may reasonably designate any competitively sensitive material to be provided to the other under this Section 5.9(c) as “Antitrust Counsel Only
Material.” Such materials and the information contained therein shall be given only to the outside antitrust counsel of the recipient and will not be disclosed by such outside counsel to employees, officers or directors of the recipient unless
express permission is obtained in advance from the source of the materials (Celgene or Bluebird, as the case may be) or its legal counsel. 
 (d) Celgene and Bluebird shall cooperate and use respectively all reasonable efforts to make all other registrations, filings and applications, to give all notices and to obtain as soon as practicable all
governmental or other consents, transfers, approvals, orders, qualifications authorizations, permits and waivers, if any, and to do all other things necessary or desirable for the consummation of the transactions as contemplated hereby. Neither
Party shall be required, however, to divest or out-license products or assets or materially change its business if doing so is a condition of obtaining approval of the transactions contemplated by this Agreement. 

(e) If a Development & Commercialization Agreement is terminated pursuant to this Section 5.9, then, notwithstanding any
provision in this Agreement to the contrary, neither Party shall have any further obligation to the other Party with respect to the subject matter of such Development & Commercialization Agreement. 

5.10 Section 365(n) of the Bankruptcy Code. All rights and licenses granted pursuant to any section of this Agreement are, and
will be deemed to be, rights and licenses to “intellectual property” (as defined in Section 101(35A) of title 11 of the United States Code and of any similar provisions of applicable Laws under any other jurisdiction (the
“Bankruptcy Code”)). Each Party agrees that the other Party, as a licensee of rights and licenses under this Agreement, 

  
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AS AMENDED. 
  

 
will retain and may fully exercise all of its rights and elections under the Bankruptcy Code. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or
against a Party under the Bankruptcy Code or analogous provisions of applicable Law outside the United States, the other Party will be entitled to a complete duplicate of (or complete access to, as appropriate) any intellectual property licensed to
such Party and all embodiments of such intellectual property, which, if not already in such Party’s possession, will be promptly delivered to it (a) upon any such commencement of a bankruptcy proceeding upon such Party’s written
request therefor, unless the Party in the bankruptcy proceeding elects to continue to perform all of its obligations under this Agreement or (b) if not delivered under clause (a), following the rejection of this Agreement by the Party in the
bankruptcy proceeding upon written request therefor by the other Party. 
  

	6.	[***] 

 6.8
Definitions. For purposes of this Section 6, 
 (a) A “Corporate Event” means a Business
Combination involving Bluebird; it being understood and agreed that, solely for purposes of this Section 6, references to “Third Party” and “Third Parties” in the definition of “Business Combination” shall be
deemed to include Celgene and, therefore, a “Corporate Event” may involve Bluebird and Celgene. 
 (b) [***]

 6.9 Call Option. Bluebird grants to Celgene the rights set forth in Exhibit L (the “Call
Option”). 
  

	7.	[***] 

  

	8.	Payments. 

 8.1
Up-Front Payment. Celgene will pay to Bluebird, within ten (10) days after the Effective Date, a one-time payment of [***] in consideration for the research and Development work to be performed by or on behalf of Bluebird as a part of
the Collaboration Program, which will be non-refundable and non-creditable and not subject to set-off. 
 8.2 First
Collaboration Extension Term Fee. In consideration for the research and Development work to be performed by or on behalf of Bluebird as a part of the Collaboration Program, Celgene will pay to Bluebird a one-time payment of [***] within [***]
after the date of the delivery to Bluebird of written notice electing to extend the Collaboration Program for the First Collaboration Program Extension Term in accordance with Section 2.1(d), which will, except as otherwise set forth in
Sections 4.3 and 12.6 hereof, Section 10.6 of the License Agreement (if applicable) or Section 17.6 of the Co-Development, Co-Promote and Profit Share Agreement (if applicable), be non-refundable and non-creditable and not subject to
set-off. 
 8.3 Second Collaboration Extension Term Fee. In consideration for the research and Development work to be
performed by or on behalf of Bluebird as a part of the Collaboration Program, Celgene will pay to Bluebird a one-time payment of [***] within [***] after the date of the delivery to Bluebird of written notice electing to extend the Collaboration
Program for the Second Collaboration Program Extension Term in accordance with Section 2.1(d), which will, except as otherwise set forth in Sections 4.3 and 12.6 hereof, Section 10.6 of the License Agreement (if applicable) or
Section 17.6 of the Co-Development, Co-Promote and Profit Share Agreement (if applicable), be non-refundable and non-creditable and not subject to set-off. 

  
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AS AMENDED. 
  

 8.4 Initial Option Fee. Subject to Sections 5.5 and 5.6, Celgene will pay to
Bluebird [***] (an “Initial Option Fee”) within [***] after the Implementation Date for each Development & Commercialization Agreement, which Initial Option Fee will, except as otherwise set forth in Sections 4.1(e),
4.3 and 12.6 hereof, Section 10.6 of the License Agreement (if applicable) or Section 17.6 of the Co-Development, Co-Promote and Profit Share Agreement (if applicable), be non-refundable and non-creditable and not subject to set-off.

 8.5 Additional Option Fee. Subject to Sections 5.5 and 5.6, Celgene will pay to Bluebird [***]
(the “Additional Option Fee”) within [***] after the later to occur of (i) Bluebird’s written notice to Celgene that Bluebird will not exercise the option set forth above in Section 5.2, (ii) Bluebird does
not deliver a Bluebird Option Notice to Celgene prior to the expiration of the [***] period following Celgene’s delivery of a Celgene Option Notice to Bluebird, and (iii) the Implementation Date, which Additional Option Fee will, except as
otherwise set forth in Sections 4.1(e), 4.3 and 12.6 hereof, Section 10.6 of the License Agreement (if applicable) or Section 17.6 of the Co-Development, Co-Promote and Profit Share Agreement (if applicable), be non-refundable and
non-creditable and not subject to set-off. 
 8.6 In-Licenses; New Celgene In-Licenses. 

(a) Pre-Existing In-Licenses. If any payments become due during the Term under any Pre-Existing In-License, Bluebird will be solely
responsible for such payments, other than as expressly provided in Section 9.2 and, provided such payment obligation is not specifically attributable to any executed Development & Commercialization Agreement, which will be addressed
thereunder. [***] Bluebird will not use any Patents, Know-How or Materials in-licensed pursuant to a Pre-Existing In-License in the Collaboration Program if Bluebird does not have the right under such Pre-Existing In-License to use such Patents,
Know-How or Materials in the Field. 
 (b) Bluebird Collaboration In-Licenses. If any payments become due during the Term
under any Bluebird Collaboration In-License, Bluebird will be solely responsible for such payments, other than as expressly provided in Section 9.2, provided that [***] 
 (c) Celgene In-Licenses. Except as otherwise provided in Sections 2.1(h)(ii), 5.7 and 12.4, Payments that become due under any Applicable Celgene In-License will be paid as set forth in
Section 4.1(e), and any royalties payable under such Applicable Product In-License will be paid by Celgene and will be subject to Section 4.3(d) of any License Agreement or Section 11.3(d) of any Co-Development, Co-Promote and Profit
Share Agreement, as applicable. 
 8.7 Taxes. [***] 

 

	9.	Patent Prosecution and Maintenance. 

 9.1 Generally. Subject to Sections 9.2 and 9.3, Bluebird will have the sole right to Prosecute and Maintain Patents within the Bluebird IP, Celgene will have the sole right to Prosecute and
Maintain Patents with the Celgene IP, and the Parties will jointly control the Prosecution and Maintenance of any Patents within jointly-owned Collaboration IP. 

  
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AS AMENDED. 
  

 9.2 Celgene Input; Expenses. Bluebird will regularly provide Celgene with copies
of all applications for Patents within the Bluebird IP, and all other material submissions and correspondence with any patent authorities regarding such Patents, in sufficient time to allow for review and comment by Celgene. In addition, Bluebird
will provide Celgene and its counsel with an opportunity to consult with Bluebird and its counsel regarding Prosecution and Maintenance of any such Patents in the Field, and Bluebird will consider in good faith all comments timely made by Celgene
and its counsel. In the event of any disagreement between any of Bluebird or Celgene, Bluebird will have the final decision-making authority with respect to the matter involved as long as Bluebird acts in good faith, provided that if Celgene
requests that Bluebird Prosecute and Maintain Patents in a particular jurisdiction, Bluebird will comply with such request, and provided further that Bluebird will not abandon Prosecution and Maintenance of any Patents within the Bluebird IP without
Celgene’s prior written consent (such consent not to be unreasonably withheld, delayed or conditioned). In addition, for each Product Candidate, the Parties shall cooperate to develop a mutually acceptable patent strategy designed to obtain
Patents that include only claims Covering the Product Candidate, pharmaceutical compositions comprising the Product Candidate, or their manufacture or use, and no other product (or its manufacture or use), and Bluebird shall, to the extent permitted
under applicable Law, use its reasonable best efforts to implement such strategy. [***] 
 9.3 Bluebird Input; Expenses.
Celgene will regularly provide Bluebird with copies of all applications for Patents (i) within Collaboration IP solely owned by Celgene pursuant to Section 2.1(f) and (ii) within the Celgene IP that are in-licensed by Celgene pursuant
to an Applicable Celgene New In-License (other than those sublicensed to Bluebird on a non-exclusive basis), and all other material submissions and correspondence with any patent authorities regarding such Patents, in sufficient time to allow for
review and comment by Bluebird. In addition, Celgene will provide Bluebird and its counsel with an opportunity to consult with Celgene and its counsel regarding Prosecution and Maintenance of any such Patents in the Field, and Celgene will consider
in good faith all comments timely made by Bluebird and its counsel. In the event of any disagreement between any of Bluebird or Celgene, Celgene will have the final decision-making authority with respect to the matter involved as long as Celgene
acts in good faith. During the Term, Celgene will be solely responsible for all Patent Costs incurred in connection with the Prosecution and Maintenance of Patents within the Celgene IP. 

9.4 Jointly Owned Collaboration IP. The Prosecution and Maintenance and the enforcement and defense of any Patents within
jointly-owned Collaboration IP will be jointly managed by the Parties on mutually agreeable terms to be entered into by the Parties at the time any such Patents are first filed, provided that (i) absent further agreement, the enforcement and
defense of any Patents within jointly-owned Collaboration IP will be governed by, and all recoveries and Patent Costs arising from the enforcement or defense of any Patents within jointly-owned Collaboration IP will be retained or borne, as
applicable, in accordance with the principles set forth in Section 2.1(f)(iii) (i.e., U.S. patent law for joint ownership of Patents will apply), and (ii) Patent Costs incurred in connection with the Prosecution and Maintenance of Patents
within jointly-owned Collaboration IP will be apportioned as set forth in Section 9.2, for the purposes of which, such Patents will be treated as Patents within the Bluebird IP, provided that in each case ((i) and (ii)), if either Party elects
not to pay any such Patent Costs for any such Patent, the Parties will meet and agree upon an equitable way to treat such Patent. 

  
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AS AMENDED. 
  

 9.5 Third Party Rights. 

(a) To the extent that a Third Party licensor of Bluebird has retained any right to Prosecute or Maintain any Patent within the Bluebird
IP licensed to Bluebird pursuant to a Bluebird In-License, or otherwise be involved in such activities, Bluebird will use commercially reasonable efforts to cause such Third Party licensor to take the actions specified by Section 9. in a manner
consistent with the Bluebird In-Licenses applicable thereto, but Bluebird will not be deemed to be in breach of its obligations under Section 9 if, after using such commercially reasonable efforts, it is unable to comply with such obligations
because of actions taken or not taken by such Third Party licensor. 
 (b) To the extent that a Third Party licensor of Celgene
has retained any right to Prosecute or Maintain any Patent within the Celgene In-Licensed IP licensed to Celgene pursuant to an Applicable Celgene In-License, or otherwise be involved in such activities, Celgene will use commercially reasonable
efforts to cause such Third Party licensor to take the actions specified by Section 9 in a manner consistent with the Applicable Celgene In-Licenses applicable thereto, but Celgene will not be deemed to be in breach of its obligations under
Section 9 if, after using such commercially reasonable efforts, it is unable to comply with such obligations because of actions taken or not taken by such Third Party licensor. 

9.6 Common Interest Disclosures. With regard to any information or opinions disclosed pursuant to this Agreement by one Party to
the other Party regarding Prosecution and Maintenance of Patent within the Bluebird IP, Celgene IP or Collaboration IP or enforcement or defense of intellectual property and/or technology by or against Third Parties, Bluebird and Celgene agree that
they have a common legal interest in determining the ownership, scope, validity and/or enforcement of the Bluebird IP, Celgene IP or Collaboration IP, and whether, and to what extent, Third Party intellectual property rights may affect the conduct
of the Development and commercialization of any Product Candidate, and have a further common legal interest in defending against any actual or prospective Third Party claims based on allegations of misuse or infringement of intellectual property
rights relating to the Development or commercialization of any Product Candidate. Accordingly, the Parties agree that all such information and materials obtained by the Parties from each other will be used solely for purposes of the Parties’
common legal interests with respect to the conduct of the Agreement and otherwise for each Party to exercise its rights and perform its obligations hereunder. All such information and materials will be treated as protected by the attorney-client
privilege, the work product privilege, and any other privilege or immunity that may otherwise be applicable. By sharing any such information and materials, neither Party intends to waive or limit any privilege or immunity that may apply to the
shared information and materials. Neither Party will have the authority to waive any privilege or immunity on behalf of the other Party without such other Party’s prior written consent, nor will the waiver of privilege or immunity resulting
from the conduct of one Party be deemed to apply against any other Party. This Section 9.6 will be subject to any right granted by Bluebird to any Third Party or by Celgene to any Third Party, provided that the grant of such right to such Third
Party does not conflict with the other Party’s rights or a Party’s obligations under this Agreement. 

  
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AS AMENDED. 
  

	10.	Confidentiality. 

10.1 Confidential Information. 
 (a) Confidential Information. Each Party (“Disclosing Party”) may have disclosed or will disclose to the other Party (“Receiving Party”), and Receiving Party may
acquire during the course and conduct of activities under this Agreement or any executed Development & Commercialization Agreement, certain proprietary or confidential information of Disclosing Party. The term “Confidential
Information” means (i) all Materials and (ii) all ideas and information of any kind, whether in written, oral, graphical, machine-readable or other form, whether or not marked as confidential or proprietary, which are transferred,
disclosed or made available by Disclosing Party or at the request of Receiving Party, including any of the foregoing of Third Parties. Without limiting the foregoing, Collaboration IP solely owned by Bluebird will be considered Confidential
Information of Bluebird, Collaboration IP solely owned by Celgene will be considered Confidential Information of Celgene, and Collaboration IP jointly owned by the Parties will be considered Confidential Information of both Parties. 

(b) Restrictions. During the Term and for ten (10) years thereafter, Receiving Party will keep all Disclosing Party’s
Confidential Information in confidence with the same degree of care with which Receiving Party holds its own confidential information, provided that the foregoing obligation will apply to any Confidential Information that constitutes a trade secret
for so long as such Confidential Information is afforded trade secret protection under applicable Law. Receiving Party will not use Disclosing Party’s Confidential Information except for in connection with the performance of its obligations and
exercise of its rights under this Agreement or any executed Development & Commercialization Agreement. Receiving Party has the right to disclose Disclosing Party’s Confidential Information without Disclosing Party’s prior written
consent (such consent not to be unreasonably withheld, delayed or conditioned), to the extent and only to the extent reasonably necessary, to Receiving Party’s Affiliates and their employees, subcontractors, sublicensees, consultants or agents
who have a need to know such Confidential Information in order to perform its obligations and exercise its rights under this Agreement or any executed Development & Commercialization Agreement and who are required to comply with
restrictions on use and disclosure similarly restrictive as those in this Section 10.1(b). Receiving Party will use diligent efforts to cause those entities and persons to comply with such restrictions on use and disclosure. Receiving Party
assumes responsibility for those entities and persons maintaining Disclosing Party’s Confidential Information in confidence and using same only for the purposes described herein. 

(c) Exceptions. Receiving Party’s obligation of nondisclosure and the limitations upon the right to use the Disclosing
Party’s Confidential Information will not apply to the extent that Receiving Party can demonstrate that the Disclosing Party’s Confidential Information: (i) was known to Receiving Party or any of its Affiliates prior to the time
of disclosure; (ii) is or becomes public knowledge through no fault or omission of Receiving Party or any of its Affiliates; (iii) is obtained by Receiving Party or any of its Affiliates from a Third Party under no obligation of
confidentiality to Disclosing Party; or (iv) has been independently developed by employees, subcontractors, consultants or agents of Receiving Party or any of its Affiliates without the aid, application or use of Disclosing Party’s
Confidential Information, as evidenced by contemporaneous written records. 

  
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AS AMENDED. 
  

 (d) Permitted Disclosures. Receiving Party may disclose Disclosing Party’s
Confidential Information to the extent (and only to the extent) such disclosure is reasonably necessary in the following instances: 
 (i) in order to comply with applicable Law (including any securities law or regulation or the rules of a securities exchange) or with a legal or administrative proceeding; 

(ii) in connection with prosecuting or defending litigation, Regulatory Approvals and other regulatory filings and communications, and
filing, prosecuting and enforcing Patents in connection with Receiving Party’s rights and obligations pursuant to this Agreement or any executed Development & Commercialization Agreement; and 

(iii) in connection with performing its obligations or exercising its rights hereunder or any executed Development &
Commercialization Agreement, to its Affiliates; and subject to Section 10.3(a), to potential and future collaborators, licensees, sublicensees and permitted acquirers or assignees, and investment bankers, investors and lenders; 

provided that (1) with respect to Sections 10.1(d)(i) or 10.1(d)(ii), where reasonably possible, Receiving Party will notify Disclosing
Party of Receiving Party’s intent to make any disclosure pursuant thereto sufficiently prior to making such disclosure so as to allow Disclosing Party adequate time to take whatever action it may deem appropriate to protect the confidentiality
of the information to be disclosed, and (2) with respect to Section 10.1(d)(iii), each of those named people and entities are required to comply with restrictions on use and disclosure at least as restrictive as those in
Section 10.1(b) (other than investment bankers, investors and lenders, which must be bound prior to disclosure by commercially reasonable obligations of confidentiality). 
 10.2 Publications. The Parties may desire to publish in scientific journals and present at scientific conferences the results of the Collaboration Program, subject to the following process.
Notwithstanding anything to the contrary herein, either Party may propose publication of the results of the Collaboration Program following scientific review by the JSC (if in force) and subsequent written approval by Bluebird’s and
Celgene’s management, which approval will not be unreasonably withheld, delayed or conditioned. After receipt of the proposed publication by both Celgene’s and Bluebird’s managements, such written approval or disapproval will be
provided within thirty (30) days. Both Parties understand that a reasonable commercial strategy may require delay of publication of information or filing of Patent applications, therefore the Parties agree to review and consider delay of
publication and filing of Patent applications under certain circumstances for a reasonably limited period of time. Once publications have been reviewed by each Party and have been approved for publication, the same publications do not have to be
provided again to the other Party for review for a later submission for publication. Expedited reviews for abstracts or poster presentations may be arranged if mutually agreeable to the Parties. Each Party will acknowledge the other Party’s
technical, non-financial contributions in any such publication. For the avoidance of doubt, the foregoing requirements and restrictions will not apply with respect to either Party’s proposed publication of results of any work performed
(i) following the expiration or termination of the Collaboration Program, or (ii) with respect to any Declined Product Candidate, in each case except as such results specifically relate to any Optioned Candidate or to any Product Candidate
for which Celgene has an option 

  
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AS AMENDED. 
  

 
hereunder (unless such option expires without Celgene having exercised such option), in which case Bluebird may not publish or present such results without Celgene’s prior written approval,
which will not be unreasonably withheld, delayed or conditioned. 
 10.3 Terms of this Agreement; Publicity. 

(a) Restrictions. The Parties agree that the terms of this Agreement (including, for clarity, for this Section 10.3(a), the
Exhibits hereto) and any executed Development & Commercialization Agreement will be treated as Confidential Information of both Parties, and thus may be disclosed only as permitted by Section 10.1(d). Each Party shall also be permitted
to disclose the terms of this Agreement, in each case under appropriate confidentiality provisions at least as protective as those contained in this Agreement, on a need to know basis, to a bona fide potential or future permitted acquirer or
assignee, investment banker, investor, licensee, sublicensee, collaborator or lender with whom a Party has entered into good faith negotiations regarding a proposed transaction, provided that (i) such disclosure is solely in the form of the
redacted version of (A) this Agreement attached hereto as Exhibit H or (B) the redacted version of such executed Development & Commercialization Agreement attached as an Appendix thereto and (ii) a corresponding
summary of financial terms for each such agreement also attached as an Exhibit or Appendix (as applicable) thereto. Only after negotiations with any such Third Party have progressed so that such Party reasonably and in good faith believes it will
execute a definitive agreement with such Third Party with respect to the proposed transaction within the following fifteen (15) business days may such Party provide an unredacted version of this Agreement and any executed Development &
Commercialization Agreement to such Third Party. In addition to the foregoing, (1) Bluebird may provide an unredacted version of this Agreement and any executed Development & Commercialization Agreement to its investment bankers and
other advisors, and (2) if Bluebird desires to enter into any such proposed transaction through an auction process, Bluebird may disclose the redacted form of this Agreement and any executed Development & Commercialization Agreement as
part of that process, along with the financial summary, and may provide an unredacted version of this Agreement and any executed Development & Commercialization Agreement to those Third Parties that make a bona fide bid as part of such
process, provided that Bluebird may not rely on this clause (2) until after the end of the Call Option Period. Except as required by Law, each Party agrees not to issue any press release or public statement disclosing information relating to
this Agreement, any executed Development & Commercialization Agreement, the transactions contemplated hereby or thereby or any of the terms hereof or thereof without the prior written consent of the other Party (such consent not to be
unreasonably withheld, delayed or conditioned), or as such consent may be obtained in accordance with Section 10.3(b), or as permitted by Section 10.3(d). 
 (b) Review. In the event either Party (the “Issuing Party”) desires to issue a press release or other public statement disclosing information relating to this Agreement, any
executed Development & Commercialization Agreement, the transactions contemplated hereby or thereby or the terms hereof or thereof, the Issuing Party will provide the other Party (the “Reviewing Party”) with a
copy of the proposed press release or public statement (the “Release”). The Issuing Party will specify with each such Release, taking into account the urgency of the matter being disclosed, a reasonable period of time
within which the Reviewing Party may provide any 

  
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AS AMENDED. 
  

 
comments on such Release and if the Reviewing Party fails to provide any comments during the response period called for by the Issuing Party, the Reviewing Party will be deemed to have consented
to the issuance of such Release. If the Reviewing Party provides any comments, the Parties will consult on such Release and work in good faith to prepare a mutually acceptable Release. If the Reviewing Party does not provide its consent, not to be
unreasonably withheld, conditioned or delayed, to the issuance of the Release, the Issuing Party will not issue the Release except as required by Law. Either Party may subsequently publicly disclose any information previously contained in any
Release so consented to. Bluebird may issue a Release upon the payment by Celgene of a fee under Section 8.2 or 8.3 to extend the Collaboration Program Term, subject to Celgene’s prior review and approval (such approval not to be
unreasonably withheld, delayed or conditioned). 
 (c) Joint Press Release. The Parties agree to issue the joint press
release on Exhibit I. 
 (d) Securities Filings. Each Party acknowledges and agrees that the other Party may
submit this Agreement (including, for clarity, the Exhibits hereto) and any executed Development & Commercialization Agreement to the United States Securities and Exchange Commission (the “SEC”) and if a Party does submit
this Agreement or any executed Development & Commercialization Agreement to the SEC, such Party agrees to consult with the other Party with respect to the preparation and submission of, a confidential treatment request for this Agreement or
such executed Development & Commercialization Agreement. If a Party is required by Law to make a disclosure of the terms of this Agreement or any executed Development & Commercialization Agreement in a filing with or other
submission to the SEC, and (i) such Party has provided copies of the disclosure to the other Party as far in advance of such filing or other disclosure as is reasonably practicable under the circumstances, (ii) such Party has promptly
notified the other Party in writing of such requirement and any respective timing constraints, and (iii) such Party has given the other Party a reasonable time under the circumstances from the date of notice by such Party of the required
disclosure to comment upon, request confidential treatment or approve such disclosure, then such Party will have the right to make such public disclosure at the time and in the manner reasonably determined by its counsel to be required by Law.
Notwithstanding anything to the contrary herein, it is hereby understood and agreed that if a Party seeking to make a disclosure to the SEC as set forth in this Section 10.3(d), and the other Party provides comments within the respective time
periods or constraints specified herein or within the respective notice, the Party seeking to make such disclosure or its counsel, as the case may be, will in good faith (A) consider incorporating such comments and (B) use reasonable
efforts to incorporate such comments, limit disclosure or obtain confidential treatment to the extent reasonably requested by the other Party. 
 10.4 Relationship to the Confidentiality Agreement. This Agreement supersedes that certain “Mutual Confidentiality Agreement” between the Parties dated May 21, 2012; provided
that all “Confidential Information” disclosed or received by the Parties thereunder will be deemed “Confidential Information” hereunder and will be subject to the terms and conditions of this Agreement. 

  
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AS AMENDED. 
  

	11.	Warranties; Limitations of Liability; Indemnification. 

 11.1 Representations and Warranties. Each Party represents and warrants to the other as of the Effective Date that it has the legal right and power to enter into this Agreement, to extend the
rights granted or to be granted to the other in this Agreement, and to fully perform its obligations hereunder. 
 11.2
Additional Representations and Warranties of Bluebird. Bluebird represents and warrants to Celgene as of the Effective Date that: 
 (a) Except for the Pre-Existing In-Licenses, neither Bluebird nor any of its Affiliates is a party to any license, sublicense or other agreement pursuant to which Bluebird or such Affiliate has received a
license or other rights relating to the Collaboration Program or the Field. 
 (b) The Pre-Existing In-Licenses in effect as of
the Effective Date are valid and binding obligations of Bluebird and, to the Knowledge of Bluebird, the applicable licensor, enforceable against Bluebird and, to the Knowledge of Bluebird, the applicable licensor, in accordance with their terms,
except as may be limited by general principles of equity (regardless of whether considered in a proceeding at law or in equity) and by applicable bankruptcy, insolvency, moratorium and other similar Laws of general application relating to or
affecting creditors’ rights generally. Neither Bluebird nor any of its Affiliates has received any notice of any counterparty’s intention to terminate any Pre-Existing In-Licenses in whole or in part or any notice requesting any amendment,
alteration or modification of such Pre-Existing In-License or any sublicense or assignment thereunder. There is no breach or default, or event which upon notice or the passage of time, or both, would give rise to any breach or default, in the
performance of any Pre-Existing In-License by Bluebird or any of its Affiliates or, to the Knowledge of Bluebird, the counterparty thereto, and Bluebird has not received any notice of any such breach, default or event. All Patents and Know-How
licensed to Bluebird under the Pre-Existing In-Licenses are Controlled by Bluebird for purposes of the licenses granted to Celgene under this Agreement and under any Development & Commercialization Agreement. 

(c) Neither Bluebird nor any of its Affiliates has entered into any agreement or otherwise licensed, granted, assigned, transferred,
conveyed or otherwise encumbered or disposed of any right, title or interest in or to any of its assets, including any intellectual property rights, that would in any way conflict with or impair the scope of any rights or licenses granted to Celgene
hereunder (including the rights granted under Section 6 and under [***]) or that would be granted to Celgene under any Development & Commercialization Agreement, including under any of the agreements which Bluebird has identified to
Celgene prior to the Effective Date. 
 (d) Exhibit J sets forth a complete and accurate list of all Patents included in
the Bluebird IP, indicating the owner, licensor and/or co-owner(s), if applicable. Bluebird Controls the Patents listed on Exhibit J and the Know-How within the Bluebird IP, and is entitled to grant the licenses specified herein. To
Bluebird’s Knowledge, the Patents listed on Exhibit J have been procured or are being procured from the respective patent offices in accordance with applicable Law. None of the Patents included in the Bluebird IP is or has been involved
in any opposition, cancellation, interference, reissue or reexamination proceeding, and no Bluebird IP is the subject of any judicial, administrative or arbitral order, award, decree, injunction, lawsuit,

  
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AS AMENDED. 
  

 
proceeding or stipulation. Neither Bluebird nor any of its Affiliates has received any notice alleging that the Patents in the Bluebird IP are invalid or unenforceable, or challenging
Bluebird’s ownership of or right to use any such rights. 
 (e) Exhibit K sets forth a complete and accurate list of
all agreements relating to the licensing, sublicensing or other granting of rights by Bluebird to any Person with respect to the Bluebird IP and the Field, and Bluebird has provided complete and accurate copies of all such agreements to Celgene.
Except for the Pre-Existing In-Licenses, Bluebird and its Affiliates are not subject to any payment obligations to Third Parties as a result of the execution or performance of this Agreement. Neither Bluebird nor any of its Affiliates has granted
any liens or security interests on the Bluebird IP and the Bluebird IP is free and clear of any mortgage, pledge, claim, security interest, covenant, easement, encumbrance, lien or charge of any kind. 

(f) The execution, delivery and performance by Bluebird of this Agreement and the consummation of the transactions contemplated hereby
will not result in any violation of, conflict with, result in a breach of or constitute a default under any understanding, contract or agreement to which Bluebird is a party or by which it is bound, including each of the agreements which Bluebird
has identified to Celgene prior to the Effective Date. 
 (g) There is no action, suit, proceeding or investigation pending or,
to the Knowledge of Bluebird, currently threatened in writing against or affecting Bluebird that questions the validity of this Agreement or the right of Bluebird to enter into this Agreement or consummate the transactions contemplated hereby.

 (h) Other than with respect to any Patents, Know-How or Materials licensed to Celgene pursuant to any of the Baylor
Agreements, (i) neither Bluebird nor any of its Affiliates has received any notice of any claim that any Patent, Know-How or other intellectual property owned or controlled by a Third Party would be infringed or misappropriated by the
production, use, research, Development, Manufacture or Commercialization of any Product Candidate pursuant to this Agreement and any Development & Commercialization Agreement, and (ii) to the Knowledge of Bluebird, there are no
Patents, Know-How or other intellectual property owned by a Third Party and not included in the Bluebird IP that are necessary for the production, use, research, Development, Manufacture or commercialization of any Product Candidate. 

11.3 Disclaimers. Without limiting the respective rights and obligations of the Parties expressly set forth herein, each
Party specifically disclaims any guarantee that the Collaboration Program will be successful, in whole or in part. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN THIS AGREEMENT, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTY OF ANY KIND,
EITHER EXPRESS OR IMPLIED, WITH RESPECT TO ANY BLUEBIRD IP, CELGENE IP, PRODUCT CANDIDATES, MATERIALS, INCLUDING WARRANTIES OF VALIDITY OR ENFORCEABILITY OF ANY PATENT RIGHTS, TITLE, QUALITY, MERCHANTABILITY, FITNESS FOR A PARTICULAR USE OR PURPOSE,
PERFORMANCE, AND NONINFRINGEMENT OF ANY THIRD PARTY PATENTS OR OTHER INTELLECTUAL PROPERTY RIGHTS.  
 11.4 [***]

  
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AS AMENDED. 
  

 11.5 Performance by Others. The Parties recognize that each Party may perform
some or all of its obligations under this Agreement through Affiliates and permitted subcontractors provided, however, that each Party will remain responsible and liable for the performance by its Affiliates and permitted subcontractors and will
cause its Affiliates and permitted subcontractors to comply with the provisions of this Agreement in connection therewith. 

11.6 Indemnification. 
 (a) Indemnification by Celgene. Celgene will indemnify Bluebird, its Affiliates and their respective directors, officers, employees, Third Party licensors and agents, and their respective
successors, heirs and assigns (collectively, “Bluebird Indemnitees”), and defend and save each of them harmless, from and against any and all losses, damages, liabilities, costs and expenses (including reasonable
attorneys’ fees and expenses) (collectively, “Losses”) in connection with any and all suits, investigations, claims or demands of Third Parties (collectively, “Third Party Claims”) against the Bluebird
Indemnitees arising from or occurring as a result of: (i) the material breach by Celgene of any term of this Agreement; (ii) Celgene’s performance of the Collaboration Program (other than with respect to claims of actual or alleged
infringement, misappropriation or other violation of a Third Party’s Patents, trade secrets, or other intellectual property or proprietary rights); or (iii) any gross negligence or willful misconduct on the part of Celgene in performing
its obligations under this Agreement, except in each case for those Losses for which Bluebird has an obligation to indemnify Celgene pursuant to Section 11.6(b), as to which Losses each Party will indemnify the other to the extent of their
respective liability; provided, however, that Celgene will not be obligated to indemnify Bluebird Indemnitees for any Losses to the extent that such Losses arise as a result of gross negligence or willful misconduct on the part of a Bluebird
Indemnitee. 
 (b) Indemnification by Bluebird. Bluebird will indemnify Celgene, its Affiliates and their respective
directors, officers, employees and agents, and their respective successors, heirs and assigns (collectively, “Celgene Indemnitees”), and defend and save each of them harmless, from and against any and all Losses in connection
with any and all Third Party Claims against Celgene Indemnitees arising from or occurring as a result of: (i) the material breach by Bluebird of any term of this Agreement; (ii) Bluebird’s performance of the Collaboration Program
(other than with respect to claims of actual or alleged infringement, misappropriation or other violation of a Third Party’s Patents, trade secrets, or other intellectual property or proprietary rights); (iii) [***]; or (iv) any gross
negligence or willful misconduct on the part of Bluebird in performing its obligations under this Agreement, except in each case for those Losses for which Celgene has an obligation to indemnify Bluebird pursuant to Section 11.6(a), as to which
Losses each Party will indemnify the other to the extent of their respective liability for the Losses; provided, however, that Bluebird will not be obligated to indemnify Celgene Indemnitees for any Losses to the extent that such Losses arise as a
result of gross negligence or willful misconduct on the part of a Celgene Indemnitee. 
 (c) Notice of Claim. All
indemnification claims provided for in Section 11.6(a) and 11.6(b) will be made solely by such Party to this Agreement (the “Indemnified Party”). The Indemnified Party will promptly notify the indemnifying Party
(an “Indemnification Claim Notice”) of any Losses or the discovery of any fact upon which the Indemnified Party intends to base a request for indemnification under Section 11.6(a) or 11.6(b), but in no event will the

  
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AS AMENDED. 
  

 
indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification Claim Notice must contain a description of the claim and the nature and
estimated amount of such Loss (to the extent that the nature and amount of such Loss is known at such time). The Indemnified Party will furnish promptly to the indemnifying Party copies of all papers and official documents received in respect of any
Losses and Third Party Claims. 
 (d) Defense, Settlement, Cooperation and Expenses. 

(i) Control of Defense. At its option, the indemnifying Party may assume the defense of any Third Party Claim by giving written
notice to the Indemnified Party within thirty (30) days after the indemnifying Party’s receipt of an Indemnification Claim Notice, provided however that (i) the Third Party Claim solely seeks monetary damages and (ii) the
indemnifying Party expressly agrees in writing that as between the indemnifying Party and the Indemnified Party, the indemnifying Party will be solely obligated to satisfy and discharge the Third Party Claim in full and is able to reasonably
demonstrate that it has sufficient financial resources (the matters described in (i) and (ii), the “Litigation Conditions”). The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed
as an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim (except as provided in the immediately prior sentence), nor will it constitute a waiver by the indemnifying Party of
any defenses it may assert against the Indemnified Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel
selected by the indemnifying Party (the indemnifying Party will consult with the Indemnified Party with respect to a possible conflict of interest of such counsel retained by the indemnifying Party). In the event the indemnifying Party assumes the
defense of a Third Party Claim, the Indemnified Party will immediately deliver to the indemnifying Party all original notices and documents (including court papers) received by the Indemnified Party in connection with the Third Party Claim. Should
the indemnifying Party assume the defense of a Third Party Claim, except as provided in Section 11.6(d)(ii), the indemnifying Party will not be liable to the Indemnified Party for any legal costs or expenses subsequently incurred by such
Indemnified Party in connection with the analysis, defense or settlement of the Third Party Claim. The Indemnified Party may, at any time, assume the defense of a Third Party Claim if at any time the Litigation Conditions are not satisfied with
respect to such Claim. In the event that it is ultimately determined that the indemnifying Party is not obligated to indemnify, defend or hold harmless the Indemnified Party from and against the Third Party Claim, the Indemnified Party will
reimburse the indemnifying Party for any and all costs and expenses (including attorneys’ fees and costs of suit) and any Third Party Claims incurred by the indemnifying Party in its defense of the Third Party Claim. 

(ii) Right to Participate in Defense. Without limiting Section 11.6(d)(i), any Indemnified Party will be entitled to
participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, however, that such employment will be at the Indemnified Party’s own cost and expense unless (i) the
employment thereof has been specifically authorized by the indemnifying Party in writing, (ii) the indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 11.6(d)(i) (in which case the Indemnified
Party will control the defense), (iii) the 

  
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AS AMENDED. 
  

 
interests of the Indemnified Party and the indemnifying Party with respect to such Third Party Claim are sufficiently adverse to prohibit the representation by the same counsel of both Parties
under applicable Law, ethical rules or equitable principles, or (iv) the indemnifying Party no longer satisfies the Litigation Conditions, in which case the indemnifying Party will assume one hundred percent (100%) of any such costs and
expenses of counsel for the Indemnified Party. 
 (iii) Settlement. With respect to any Third Party Claims that relate
solely to the payment of money damages in connection with a Third Party Claim and that will not result in the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified
Party in any manner, and as to which the indemnifying Party will have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, and subject to the Litigation Conditions being satisfied, the indemnifying Party will have the
sole right to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, will deem appropriate. With respect to all other Losses in connection
with Third Party Claims, where the indemnifying Party has assumed the defense of the Third Party Claim in accordance with Section 11.6(d)(i), the indemnifying Party will have authority to agree to the entry of any judgment, enter into any
settlement or otherwise dispose of such Loss provided it obtains the prior written consent of the Indemnified Party (such consent not to be unreasonably withheld, delayed or conditioned). The indemnifying Party will not be liable for any settlement
or other disposition of a Loss by an Indemnified Party that is reached without the prior written consent of the indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified
Party will admit any liability with respect to or settle, compromise or discharge, any Third Party Claim without the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld, delayed or conditioned. 

(iv) Cooperation. If the indemnifying Party chooses to defend or prosecute any Third Party Claim, the Indemnified Party will, and
will cause each other Indemnified Party to, cooperate in the defense or prosecution thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and
appeals as may be reasonably requested in connection therewith. Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that
are reasonably relevant to such Third Party Claim, and making Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the
indemnifying Party will reimburse the Indemnified Party for all its reasonable out-of-pocket costs and expenses in connection therewith. 
 (v) Costs and Expenses. Except as provided above in this Section 11.6(d), the costs and expenses, including attorneys’ fees and expenses, incurred by the Indemnified Party in connection
with any claim will be reimbursed on a calendar quarter basis by the indemnifying Party, without prejudice to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the
indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 
 11.7 [***] 

  
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AS AMENDED. 
  

	12.	Term and Termination. 

 12.1 Term. This Agreement will commence as of the Effective Date and, unless sooner terminated in accordance with the terms hereof or by mutual written consent, will continue until the later of the
expiration of the Collaboration Program Term and expiration of the last-to-expire Celgene Option Period (the “Term”). 
 12.2 Termination by Bluebird. Bluebird will have the right to terminate this Agreement in full upon delivery of written notice to Celgene in the event of any material breach by Celgene of any terms
and conditions of this Agreement in a manner that fundamentally frustrates the transactions contemplated by this Agreement, provided that such termination will not be effective if such breach has been cured within [***] after written notice thereof
is given by Bluebird to Celgene specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] after such notice if Celgene commences actions to cure such default within such [***] and thereafter diligently
continues such actions, but fails to cure the default by the end of such [***]); provided, however, that to the extent such material breach involves the failure to make a payment when due, such breach must be cured within [***] after written notice
thereof is given by Bluebird to Celgene. 
 12.3 Termination by Celgene. 

(a) Breach. Celgene will have the right to terminate this Agreement in full upon delivery of written notice to Bluebird in the
event of any material breach by Bluebird of any terms and conditions of this Agreement in a manner that fundamentally frustrates the transactions contemplated by this Agreement, provided that such termination will not be effective if such breach has
been cured within [***] after written notice thereof is given by Celgene to Bluebird specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] after such notice if Bluebird commences actions to cure such
default within such [***] and thereafter diligently continues such actions, but fails to cure the default by the end of such [***]). 
 (b) Discretionary Termination. Celgene will have the right to terminate this Agreement in full at its discretion for any reason [***] days after delivery of written notice to Bluebird. 

12.4 Effects of Termination or Expiration. Upon termination or expiration of this Agreement for any reason, all rights granted by
Bluebird to Celgene hereunder will terminate, provided that: 
 (a) IND Product Candidates. Bluebird will, at
Celgene’s election, complete initial Phase 1 Studies for one (1) or more IND Product Candidates selected by Celgene, and, if Celgene elects not to have Bluebird complete any such Phase 1 Study, Bluebird may do so at its own expense. In
either case, (i) the provisions of Sections 5.1 through 5.6 will apply with respect to any such IND Product Candidates (but excluding Section 5.3 if Celgene has terminated this Agreement pursuant to Section 12.3(a)), (ii) Celgene
will grant to Bluebird an exclusive, worldwide, royalty-free right and license in the Field, without the right to grant sublicenses (other than to permitted subcontractors under Section 2.4), under the Celgene IP and Celgene’s interest in
jointly owned Collaboration IP solely to complete any such Phase 1 Study, 

  
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AS AMENDED. 
  

 
and (iii) if Celgene has elected to have Bluebird complete such Phase 1 Study, or if Celgene has not elected to have Bluebird complete a Phase 1 Study but Bluebird has completed such Phase 1
Study and Celgene exercises its option with respect to such IND Product Candidate as set forth in Section 5.1, Celgene will reimburse Bluebird for [***] Notwithstanding the foregoing, if Bluebird has terminated this Agreement pursuant to
Section 12.2, upon Celgene’s exercise of its option with respect to an IND Product Candidate as set forth in Section 5.1, in lieu of paying the Option Fees and reimbursing Bluebird for its costs and expenses incurred in connection
with completing a Phase 1 Study for such IND Product Candidate, Celgene will pay to Bluebird an amount equal to the greater of [***] If Celgene does not exercise its option with respect to such IND Product Candidate as set forth in Section 5.1,
Bluebird (or an Affiliate designated by Bluebird) and Celgene will, at Bluebird’s option, enter into a License Agreement in the form attached hereto as Exhibit A with respect to the IND Product Candidate, but reversing the roles of
the Parties thereunder, mutatis mutandis, and updating the Appendices thereto and making such other changes as are appropriate from the context, provided that (A) such license shall be limited to the Celgene IP and jointly owned
Collaboration IP as it exists at the time this Agreement has expired or been terminated (including in each case any additions, divisions, continuations, continuations-in-part, invention certificates, substitutions, reissues, reexaminations,
extensions, registrations, supplementary protection certificates and renewals of such Celgene IP and Joint Collaboration IP), (B) no Option Fee will be payable by Bluebird in connection with such IND Product Candidates, (C) any royalties
or Milestone Payments payable under such License Agreement will be reduced [***], (D) such IND Product Candidate will not be subject to the provisions of Section 5.7, (E) if any royalty, milestone or other payment, excluding [***],
becomes due under any Applicable Celgene In-License that is attributable to Bluebird as a sublicensee (together with its licensees and their respective Affiliates) thereunder with respect to such Development, Manufacture or commercialization,
Celgene will pay same, provided that Bluebird will reimburse Celgene for any such payment within thirty (30) days of Bluebird’s receipt of Celgene’s written invoice therefor, and Bluebird’s failure to pay such reimbursement
within such time period will entitle Celgene to terminate Bluebird’s sublicense under the applicable Celgene In-License upon thirty (30) days written notice, (F) such License Agreement will be subject to any Target Antigen-related
exclusivity agreed to between the Parties under any Development & Commercialization Agreement (whether executed before or after the date of such License Agreement), and (G) Bluebird will be responsible for [***] of any amounts owed to
Third Parties (including under any Bluebird In-License) in connection with the acquisition of rights in order to Develop or commercialize such IND Product Candidates, provided that any such payments that are royalties will be subject to
Section 4.3(d) of such License Agreement. 
 (b) Outstanding Options. Any options exercised by Celgene pursuant to
Section 5.1 that have not at the time of termination or expiration resulted in an executed Development & Commercialization Agreement will, at Celgene’s option, be consummated pursuant to Sections 5.2 through 5.4, and
Bluebird’s option under Section 5.3 will not terminate unless Celgene has terminated this Agreement pursuant to Section 12.3(a). 

  
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AS AMENDED. 
  

 (c) Pre-IND Product Candidates. For all Product Candidates (other than Optioned
Candidates and IND Product Candidates) for which in vivo efficacy or safety studies have been initiated or authorized by the JSC (each, a “Pre-IND Product Candidate”), the following will apply: 

(i) The Parties will choose from the pool of Pre-IND Product Candidates as follows: 

(A) if such termination is by Celgene pursuant to Section 12.3(a), Celgene will select the first and second Pre-IND Product
Candidates, Bluebird will select the third and fourth Pre-IND Product Candidates, and thereafter the selection of each Pre-IND Product Candidate will alternate between Celgene and Bluebird until all Pre-IND Product Candidates have been selected;

 (B) if such termination is by Bluebird pursuant to Section 12.2, Bluebird will select the first and second Pre-IND
Product Candidates, Celgene will select the third and fourth Pre-IND Product Candidates, and thereafter the selection of each Pre-IND Product Candidate will alternate between the Bluebird and Celgene until all Pre-IND Product Candidates have been
selected; 
 (C) if such termination or expiration occurs other than pursuant to Sections 12.2 or 12.3(a), the first Party to
select from the pool of Pre-IND Product Candidates will be chosen by a coin toss. The winner of the coin toss will have the right to select the first Pre-IND Product Candidate, or may instead allow the other Party to select the first Pre-IND Product
Candidate. The Party that does not make the first selection from the pool of Pre-IND Product Candidates will have the second and third selections, and thereafter the selection of each Pre-IND Product Candidate will alternate between the Parties
until all Pre-IND Product Candidates have been selected; and 
 (D) In selecting from the pool of Pre-IND Product Candidates,
Bluebird will not select any Pre-IND Product Candidate that targets the same Target Antigen that is targeted by any Optioned Candidates or the same Target Antigen that is targeted by the first Pre-IND Product Candidate selected by Celgene pursuant
to Section 12.4(c)(i). 
 (E) In selecting from the pool of Pre-IND Product Candidates, Celgene will not select any
Pre-IND Product Candidate that targets the same Target Antigen that is targeted by the first Pre-IND Product Candidate selected by Bluebird pursuant to Section 12.4(c)(i). 

(ii) For the first Pre-IND Product Candidate selected by Celgene pursuant to Section 12.4(c)(i), Bluebird will grant to Celgene an
exclusive, worldwide, royalty-free right and license in the Field, without the right to grant sublicenses (other than to permitted subcontractors under Section 2.4), under the Bluebird IP and Bluebird’s interest in jointly owned
Collaboration IP, solely to conduct research and Development activities with respect to such Pre-IND Product Candidate during the applicable Celgene Option Period. Celgene will have the exclusive option to take an exclusive license from Bluebird
under the Bluebird IP and Bluebird’s interest in jointly owned Collaboration IP to commercialize such Pre-IND Product Candidate, exercisable by providing to Bluebird a Celgene Option Notice for same within the time period set forth in
Section 5.1. Upon such election by Celgene, the provisions of Sections 5.2 through 5.7 (but excluding Section 5.3 if Celgene has terminated this Agreement pursuant to Section 12.3(a)), Section 5.9 and Sections 8.4 and 8.5 will
apply with respect to such Pre-IND Product Candidate, 

  
 44 

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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
provided that (A) the Option Fees payable with respect to such Pre-IND Candidate will be reduced by [***], (B) any royalties or Milestone Payments payable under the applicable
Development & Commercialization Agreement with respect to such Pre-IND Product Candidate will be reduced by [***], (C) Celgene will be responsible for [***] of any In-License Payments under the applicable Development &
Commercialization Agreement, and other amounts owed to Third Parties (including under any Celgene In-License) in connection with the acquisition of rights in order to Develop or commercialize such Pre-IND Product Candidate, provided that any such
In-License Payments and such other payments that are royalties will be subject to Section 4.3(d) of such License Agreement or Section 11.3(d) of any Co-Development, Co-Promote and Profit Share Agreement, as applicable, and (D) Celgene
will not have any diligence obligations with respect to such Pre-IND Product Candidate under such Development & Commercialization Agreement. 
 (iii) For the first Pre-IND Product Candidate selected by Bluebird pursuant to Section 12.4(c)(i), the provisions of Sections 5.1 through 5.6 and Section 5.9 will apply and Celgene will grant to
Bluebird an exclusive, worldwide, royalty-free right and license in the Field, without the right to grant sublicenses (other than to permitted subcontractors under Section 2.4), under the Celgene IP and Celgene’s interest in jointly owned
Collaboration IP solely to conduct research and Development activities with respect to such Pre-IND Product Candidate. If any royalty, milestone or other payment becomes due under any Applicable Celgene In-License that is attributable to Bluebird as
a sublicensee (together with its licensees and their respective Affiliates) thereunder with respect to such Development work, Celgene will pay same, provided that Bluebird will reimburse Celgene for any such payment within thirty (30) days of
Bluebird’s receipt of Celgene’s written invoice therefor, and Bluebird’s failure to pay such reimbursement within such time period will entitle Celgene to terminate Bluebird’s sublicense under the applicable Celgene In-License
upon [***] written notice. If Celgene exercises its option with respect to such Pre-IND Product Candidate as set forth in Section 5.1, Celgene will reimburse Bluebird for [***] If Celgene does not exercise its option with respect to such
Pre-IND Product Candidate as set forth in Section 5.1, at Bluebird’s option, Bluebird (or an Affiliate designated by Bluebird) and Celgene will enter into a License Agreement in the form attached hereto as Exhibit A with
respect to such Pre-IND Product Candidate, but reversing the roles of the Parties thereunder, mutatis mutandis, and updating the Appendices thereto and making such other changes as are appropriate from the context, provided that (A) such
license shall be limited to the Celgene IP and jointly owned Collaboration IP as it exists at the time this Agreement has expired or been terminated (including in each case any additions, divisions, continuations, continuations-in-part, invention
certificates, substitutions, reissues, reexaminations, extensions, registrations, supplementary protection certificates and renewals of such Celgene IP and Joint Collaboration IP), (B) no Option Fee will be payable by Bluebird in connection
with such Pre-IND Product Candidate, (C) any royalties or Milestone Payments payable under such License Agreement will be reduced by [***], (D) such License Agreement will include Target Antigen-related exclusivity, (E) Milestone
Payments under such License Agreement are payable with respect to each Pre-IND Product Candidate to achieve an applicable Milestone Event, (F) Bluebird will be responsible for [***] of any amounts owed to Third Parties (including under any
Bluebird In-License) in connection with the acquisition of rights in order to Develop or commercialize such Pre-IND Product Candidates, provided that any such payments 

  
 45 

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AS AMENDED. 
  

 
that are royalties will be subject to Section 4.3(d) of such License Agreement, (G) such Pre-IND Product Candidate will not be subject to the provisions of Section 5.7, (H) if
any royalty, milestone or other payment becomes due under any Celgene In-License that is attributable to Bluebird as a sublicensee (together with its licensees and their respective Affiliates) thereunder with respect to such Development, Manufacture
or commercialization, Celgene will pay same, provided that Bluebird will reimburse Celgene for any such payment excluding [***], and Bluebird’s failure to pay such reimbursement within such time period will entitle Celgene to terminate
Bluebird’s sublicense under the applicable Celgene In-License upon thirty (30) days written notice, and (I) bluebird will not have any diligence obligations with respect to such Pre-IND Product Candidate under such
Development & Commercialization Agreement. 
 (iv) Except with respect to the first Pre-IND Product Candidate selected
by Celgene pursuant to Section 12.4(c)(i), Celgene (or an Affiliate designated by Celgene) and Bluebird, subject to Section 5.9, will enter into a License Agreement in the form attached hereto as Exhibit A with respect to the
Pre-IND Product Candidates selected by Celgene in accordance with Section 12.4(c)(i), updating the Appendices thereto and making such other changes as are appropriate from the context, provided that (A) such license shall be limited to the
Bluebird IP and jointly owned Collaboration IP as it exists at the time this Agreement has expired or been terminated (including in each case any additions, divisions, continuations, continuations-in-part, invention certificates, substitutions,
reissues, reexaminations, extensions, registrations, supplementary protection certificates and renewals of such Celgene IP and Joint Collaboration IP), (B) no Option Fee will be payable by Celgene in connection with such Pre-IND Product
Candidates, (C) any royalties or Milestone Payments payable under such License Agreement will be reduced by [***], (D) Milestone Payments under such License Agreement are payable with respect to each Pre-IND Product Candidate to achieve an
applicable Milestone Event, (E) such License Agreement will not include Target Antigen-related exclusivity, (F) Celgene will be responsible for [***] of any In-License Payments under such License Agreement, and other amounts owed to Third
Parties (including under any Celgene In-License) in connection with the acquisition of rights in order to Develop or commercialize such Pre-IND Product Candidates, provided that any such In-License Payments and such other payments that are royalties
will be subject to Section 4.3(d) of such License Agreement, and (G) Celgene will not have any diligence obligations with respect to such Pre-IND Product Candidate under such Development & Commercialization Agreement. 

(v) Except with respect to the first Pre-IND Product Candidate selected by Bluebird pursuant to Section 12.4(c)(i), Bluebird (or an
Affiliate designated by Bluebird) and Celgene, subject Section 5.9, will enter into a License Agreement in the form attached hereto as Exhibit A with respect to the Pre-IND Product Candidates selected by Bluebird in accordance with
Section 12.4(c)(i), but reversing the roles of the Parties thereunder, mutatis mutandis, and updating the Appendices thereto and making such other changes as are appropriate from the context, provided that (A) such license shall be
limited to the Celgene IP and jointly owned Collaboration IP as it exists at the time this Agreement has expired or been terminated (including in each case any additions, divisions, continuations, continuations-in-part, invention certificates,
substitutions, reissues, reexaminations, extensions, registrations, supplementary protection certificates and renewals of such Celgene IP and Joint Collaboration IP), (B) no Option Fee will be payable by Bluebird in connection with such Pre-IND
Product Candidates, (C) any royalties 

  
 46 

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AS AMENDED. 
  

 
or Milestone Payments payable under such License Agreement will be reduced by [***], (D) such License Agreement will not include Target Antigen-related exclusivity, (E) Milestone
Payments under such License Agreement are payable with respect to each Pre-IND Product Candidate to achieve an applicable Milestone Event, (F) Bluebird will be responsible for [***] of any amounts owed to Third Parties (including under any
Bluebird In-License) in connection with the acquisition of rights in order to Develop or commercialize such Pre-IND Product Candidates, provided that any such payments that are royalties will be subject to Section 4.3(d) of such License
Agreement, (G) if any royalty, milestone or other payment becomes due under any Celgene In-License that is attributable to Bluebird as a sublicensee (together with its licensees and their respective Affiliates) thereunder with respect to such
Development, Manufacture or commercialization, Celgene will pay same, provided that Bluebird will reimburse Celgene for any such payment, excluding [***], within thirty (30) days of Bluebird’s receipt of Celgene’s written invoice
therefor, and Bluebird’s failure to pay such reimbursement within such time period will entitle Celgene to terminate Bluebird’s sublicense under the applicable Celgene In-License upon thirty (30) days written notice, and
(H) Bluebird will not have any diligence obligations with respect to such Pre-IND Product Candidate under such Development & Commercialization Agreement. 
 (d) Neither Party will (i) Develop an IND Product Candidate or Pre-IND Product Candidate following the expiration of the applicable option period set forth in this Section 12.4 with respect to
such IND Product Candidate or Pre-IND Product Candidate, or (ii) Commercialize any IND Product Candidate or Pre-IND Product Candidate in each case ((i) and (ii)) without first entering into a License Agreement with the other Party in the form
attached hereto as Exhibit A with respect to such IND Product Candidate or Pre-IND Product Candidate as set forth in this Section 12.4. For clarity, any agreement in the form of License Agreement attached hereto as
Exhibit A entered into between the Parties pursuant to this Section 12.4 with respect to an IND Product Candidate or Pre-IND Product Candidate, and any resulting Co-Development, Co-Promote and Profit Share Agreement, shall be
“Development & Commercialization Agreements” hereunder. 
 (e) Other than with respect to the rights and
licenses granted to Bluebird hereunder pursuant to Section 2.1(h)(ii), all rights granted by Celgene to Bluebird hereunder will terminate. 
 (f) All executed Development & Commercialization Agreements will continue in full force and effect, provided that if Celgene has terminated this Agreement pursuant to Section12.3(a), then
(i) Bluebird’s rights to co-develop, co-promote and share in profits under any Co-Development, Co-Promote and Profit Share Agreements will terminate, and the Parties promptly will execute a License Agreement to replace each such
Co-Development, Co-Promote and Profit Share Agreement, and (ii) all up-front payments, milestone payments and royalty payments under any License Agreement will be reduced by [***], provided that such reduction will not apply to the extent any
such up-front payments, milestone payments and royalty payments have already been reduced pursuant to Section 10.3(c) of such License Agreement. 
 12.5 Survival. In addition to the termination consequences set forth in Section 12.4, the following provisions will survive termination or expiration of this Agreement: Sections 1, 2.1(f),
2.1(h)(ii), 2.2, 2.3(a), 2.3(c), 4.3(through the expiration of any options granted to Celgene hereunder), 4.5, 4.6, 5.5, 5.7, 5.8, 5.9, 5.10, 8.7, 9.4, 10, 11, 12.4, 

  
 47 

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AS AMENDED. 
  

 
12.5 and 13, and any other provisions of this Agreement that are required to survive to give effect to any Development & Commercialization Agreement. Termination or expiration of this
Agreement will not relieve the Parties of any liability or obligation which accrued hereunder prior to the effective date of such termination or expiration nor preclude either Party from pursuing all rights and remedies it may have hereunder or at
law or in equity with respect to any breach of this Agreement nor prejudice either Party’s right to obtain performance of any obligation. All other rights and obligations will terminate upon expiration of this Agreement. 

12.6 Right to Set-off. Notwithstanding anything to the contrary in this Agreement, each Party has the right at all times to retain
and set off against all amounts due and owing to the other Party as determined in a final judgment any damages recovered by such Party for any Losses incurred by such Party. 

 

	13.	General Provisions. 

13.1 Dispute Resolution for this Agreement and Executed Development & Commercialization Agreements. 

(a) Disputes. Disputes arising under or in connection with this Agreement or any executed Development and Commercialization
Agreement will be resolved pursuant to this Section 13.1. 
 (b) Dispute Escalation. In the event of a dispute
between the Parties, the Parties will first attempt in good faith to resolve such dispute by negotiation and consultation between themselves or the Program Directors. In the event that such dispute is not resolved on an informal basis within
twenty (20) days, any Party may, by written notice to the other, have such dispute referred to the Bluebird CEO and the Celgene CEO or in either case his or her designee (who will be a senior executive), who will attempt in good faith to
resolve such dispute by negotiation and consultation for a thirty (30) day period following receipt of such written notice. 
 (c) Dispute Resolution. In the event the Parties are not able to resolve such dispute in accordance with Section 13.1(b), either Party may at any time after such 20-day period submit such
dispute to be finally settled in the federal courts located in the Southern District of New York. Each Party hereby irrevocably and unconditionally consents to submit to the exclusive jurisdiction of the federal courts located in the Southern
District of New York, for any actions, suits or proceedings arising out of or relating to this Agreement and the transactions contemplated hereby. Each Party hereby irrevocably and unconditionally waives any objection to the laying of venue of any
action, suit or proceeding arising out of or relating to this Agreement and the transactions contemplated hereby in the federal courts located in the Southern District of New York, and waives and agrees not to plead or claim in any such court that
any such action, suit or proceeding brought in such court has been brought in an inconvenient forum. Notwithstanding the foregoing, a Party will be entitled to seek enforcement of a judgment entered pursuant to this Section in any court having
competent jurisdiction thereof where enforcement is deemed necessary. 
 (d) Injunctive Relief. Notwithstanding the
dispute resolution procedures set forth in this Section 13.1, in the event of an actual or threatened breach hereunder (or any executed Development & Commercialization Agreement, if applicable), the aggrieved Party may seek

  
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AS AMENDED. 
  

 
equitable relief (including restraining orders, specific performance or other injunctive relief) in any court or other forum, without first submitting to any dispute resolution procedures
hereunder. 
 (e) Tolling. The Parties agree that all applicable statutes of limitation and time-based defenses (such as
estoppel and laches) will be tolled while the dispute resolution procedures set forth in this Section 13.1 are pending, and the Parties will cooperate in taking all actions reasonably necessary to achieve such a result. In addition, during the
pendency of any dispute under this Agreement initiated before the end of any applicable cure period under Section 12.2 or 12.3 (or the cure periods under any executed Development & Commercialization Agreement, if applicable),
(i) this Agreement (or any executed Development & Commercialization Agreement, if applicable) will remain in full force and effect, (ii) the provisions of this Agreement (or any executed Development & Commercialization
Agreement, if applicable) relating to termination for material breach will not be effective, (iii) the time periods for cure under Section 12 (and the time periods from any executed Development & Commercialization Agreement, if
applicable) as to any termination notice given prior to the initiation of the court proceeding will be tolled, and (iv) neither Party will issue a notice of termination pursuant to this Agreement (or any executed Development &
Commercialization Agreement, if applicable) based on the subject matter of the court proceeding (and no effect will be given to previously issued termination notices), until the court has confirmed the existence of the facts claimed by a Party to be
the basis for the asserted material breach. 
 13.2 Cumulative Remedies and Irreparable Harm. All rights and remedies of
the Parties hereunder will be cumulative and in addition to all other rights and remedies provided hereunder or available by agreement, at law or otherwise. Each Party acknowledges and agrees that breach of any of the terms or conditions of this
Agreement would cause irreparable harm and damage to the other and that such damage may not be ascertainable in money damages and that as a result thereof the non-breaching Party would be entitled to seek from a court equitable or injunctive relief
restraining any breach or future violation of the terms contained herein by the breaching Party without the necessity of proving actual damages or posting bond. Such right to equitable relief is in addition to whatever remedies either Party may be
entitled to as a matter of law or equity, including money damages. 
 13.3 Business Combination and IP. 

(a) Bluebird Business Combination. Notwithstanding anything to the contrary herein, for purposes of this Agreement and any
Development & Commercialization Agreement, no Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Bluebird or any of its Affiliates prior to a Business Combination of Bluebird will be
Controlled for purposes of this Agreement or any Development & Commercialization Agreement after such Business Combination of Bluebird, other than (i) Collaboration IP, (ii) Bluebird In-Licenses to the extent in effect immediately
prior to such Business Combination of Bluebird and later Bluebird Collaboration In-Licenses (provided that after any such Business Combination, Bluebird may, but will not be obligated to, make any Bluebird New In-License available to Celgene or the
JSC for review, election or conversion into a Bluebird Collaboration In-License pursuant to Section 4.1), and (iii) any Patent that claims priority, directly or indirectly, to any other Patent first Controlled before such Business
Combination of Bluebird will be Controlled thereafter no matter when such Patent is filed or issued. 

  
 49 

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AS AMENDED. 
  

 (b) Celgene Business Combination. Notwithstanding anything to the contrary
herein, for purposes of this Agreement and any Development & Commercialization Agreement, no Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Celgene or any of its Affiliates prior
to a Business Combination of Celgene will be Controlled for purposes of this Agreement or any Development & Commercialization Agreement after such Business Combination of Celgene, other than (i) Collaboration IP, (ii) Applicable
Celgene In-Licenses, and (iii) any Patent that claims priority, directly or indirectly, to any other Patent first Controlled before such Business Combination of Celgene will be Controlled thereafter no matter when such Patent is filed or
issued. 
 13.4 Relationship of Parties. Nothing in this Agreement is intended or will be deemed to constitute a
partnership, agency, employer-employee or joint venture relationship between the Parties. No Party will incur any debts or make any commitments for the other, except to the extent, if at all, specifically provided therein. There are no express or
implied third party beneficiaries hereunder (except for Bluebird Indemnitees and Celgene Indemnitees, and any Third Party indemnitees under any executed Development & Commercialization Agreement, if applicable, for purposes of
Section 11.6). 
 13.5 Compliance with Law. Each Party will perform or cause to be performed any and all of its
obligations or the exercise of any and all of its rights hereunder in good scientific manner and in compliance with all applicable Law. Without limiting the foregoing, Bluebird will comply with comply with all applicable Laws and regulations
(including U.S. Foreign Corrupt Practices Act and any other applicable anti-bribery or anti-kickback laws or regulations). 

13.6 Force Majeure. Neither Party will be liable to the other for failure of or delay in performing obligations set forth in this
Agreement (other than any obligation to pay monies when due), and neither will be deemed in breach of such obligations, if such failure or delay is due to natural disasters or any causes reasonably beyond the control of such Party and without the
fault or negligence of the Party so failing or delaying; provided that the Party affected will promptly notify the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any such causes and to resume
performance of its obligations as soon as possible. 
 13.7 Governing Law. This Agreement will be governed by and
construed in accordance with the Laws of the state of New York, without respect to its conflict of laws rules; provided, however, that any dispute relating to the scope, validity, enforceability or infringement of any Patents or Know-How will be
governed by, and construed and enforced in accordance with, the substantive Laws of the jurisdiction in which such Patents or Know-How apply. 
 13.8 Counterparts; Facsimiles. This Agreement may be executed in one or more counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the same
instrument. Facsimile or PDF execution and delivery of this Agreement by either Party will constitute a legal, valid and binding execution and delivery of this Agreement by such Party 

  
 50 

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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 13.9 Headings. All headings in this Agreement are for convenience only and will
not affect the meaning of any provision hereof. 
 13.10 Waiver of Rule of Construction. Each Party has had the
opportunity to consult with counsel in connection with the review, drafting and negotiation of this Agreement. Accordingly, the rule of construction that any ambiguity in this Agreement will be construed against the drafting party will not apply.

 13.11 Interpretation. Whenever any provision of this Agreement uses the term “including” (or
“includes”), such term will be deemed to mean “including without limitation” (or “includes without limitations”). “Herein,” “hereby,” “hereunder,” “hereof” and other
equivalent words refer to this Agreement as an entirety and not solely to the particular portion of this Agreement in which any such word is used. All definitions set forth herein will be deemed applicable whether the words defined are used herein
in the singular or the plural. Unless otherwise provided, all references to Sections and Exhibits in this Agreement are to Sections and Exhibits of this Agreement. References to any Sections include Sections and subsections that are part of the
related Section (e.g., a section numbered “Section 2.1” would be part of “Section 2”, and references to “Section 2.1” would also refer to material contained in the subsection described
as “Section 2.1(a)”). 
 13.12 Binding Effect. This Agreement will inure to the benefit of and be
binding upon the Parties, their Affiliates, and their respective lawful successors and assigns. 
 13.13 Assignment. This
Agreement may not be assigned by either Party, nor may either Party delegate its obligations or otherwise transfer licenses or other rights created by this Agreement, except as expressly permitted hereunder or otherwise without the prior written
consent of the other Party, which consent will not be unreasonably withheld, delayed or conditioned; provided that without consent (i) Celgene may assign this Agreement to (x) an Affiliate or (y) its successor in connection with the
merger, consolidation, or sale of all or substantially all of its assets, and (ii) Bluebird may assign this Agreement to (x) an Affiliate or (y) its successor in connection with the merger, consolidation, or sale of all or
substantially all of its assets or that portion of its business pertaining to the subject matter of this Agreement; provided however that, except in the case where a Party is involved in a merger or consolidation where it is the surviving entity and
no assets of such Party have been transferred as a result of such merger or consolidation, that (A) such assigning Party provides the other Party to this Agreement with at least thirty (30) business days advance written notice of such
assignment(s) and the assigning Party agrees in a written agreement delivered prior to such assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to remain fully liable for the performance of its obligations
under this Agreement by its assignee(s), (B) the assignee(s) agree in a written agreement delivered prior to such assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to assume performance of all such
assigned obligations, (C) in the case of any assignment(s) by Bluebird, all Bluebird IP licensed to Celgene or subject to Celgene’s option rights under this Agreement, along with all Product Candidates will be transferred to such
assignee(s) effective as of such assignment(s), (D) all of the matters referred to in clauses (A), (B) and (C), as applicable, will be set forth in documentation reasonably acceptable to the non-assigning Party prior to any such
assignment(s) (and with such reasonable acceptance not to be unreasonably withheld, conditioned or delayed) and in all cases 

  
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AS AMENDED. 
  

 
will provide the non-assigning Party with the full benefits of its rights under this Agreement (after taking into account all risks involving applicable counter-party performance and bankruptcy
and insolvency risks, including those involving contractual rejection under 11 USC §365) as if no such assignment(s) had occurred, and (E) in the case of any assignment(s), the assigning Party will reimburse the non-assigning Party for all
of the legal fees and expenses incurred by such non-assigning Party in connection with the matters set forth in clause (D) of this sentence in an aggregate amount not to exceed $50,000; and provided, further, that if Bluebird wishes to assign
any Bluebird IP to its Affiliates, it will be permitted to do so conditioned on such Affiliate becoming a party to this Agreement, in the form of an amendment to this Agreement executed by Celgene, Bluebird and such Affiliate, pursuant to which such
Affiliate would agree to assume all obligations hereunder, and grant to Celgene all rights hereunder, with respect to the Bluebird IP so assigned. The terms of this Agreement will be binding upon and will inure to the benefit of the successors,
heirs, administrators and permitted assigns of the Parties. Any purported assignment in violation of this Section 13.13 will be null and void ab initio. 
 13.14 Notices. All notices, requests, demands and other communications required or permitted to be given pursuant to this Agreement will be in writing and will be deemed to have been duly given
upon the date of receipt if delivered by hand, recognized international overnight courier, confirmed facsimile transmission, or registered or certified mail, return receipt requested, postage prepaid to the following addresses or facsimile numbers:

  

			
	If to Bluebird:	    	bluebird bio, Inc.
		    	840 Memorial Drive
		    	Cambridge, MA 02139
		    	Attention: President & CEO
		    	Facsimile:
		
	With a copy to:	    	Goodwin|Procter LLP
		    	53 State Street
		    	Boston, MA 02109
		    	Attention: Michael Bison, Esq. & Kingsley Taft, Esq.
		    	Facsimile: 617-523-1231
		
	If to Celgene:	    	Celgene Corporation
		    	86 Morris Avenue
		    	Summit, NJ 07901
		    	Attention: George Golumbeski, Ph. D.
		    	Facsimile: 908-673-2791

  
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AS AMENDED. 
  

					
	with a copy to:	    	Celgene Legal
		    	86 Morris Avenue
		    	Summit, NJ 07901
		    	Attention: General Counsel
		    	Telephone: (908) 673-9000
		    	Facsimile: (908) 673-2771
		
		    	Dechert LLP
		    	902 Carnegie Center
		    	Suite 500
		    	Princeton, NJ 08540
		    	Attention:	    	James J. Marino, Esq.
		    		    	David E. Schulman, Esq.
		    	Telephone:	    	(609) 955-3230
		    	Facsimile:	    	(609) 873-9138

 Either Party may change its designated address and facsimile number by notice to the other Party in the manner provided
in this Section 13.14. 
 13.15 Amendment and Waiver. This Agreement may be amended, supplemented, or otherwise
modified only by means of a written instrument signed by both Parties; provided that any unilateral undertaking or waiver made by one Party in favor of the other will be enforceable if undertaken in a writing signed by the Party to be charged with
the undertaking or waiver. Any waiver of any rights or failure to act in a specific instance will relate only to such instance and will not be construed as an agreement to waive any rights or fail to act in any other instance, whether or not
similar. 
 13.16 Severability. In the event that any provision of this Agreement will, for any reason, be held to be
invalid or unenforceable in any respect, such invalidity or unenforceability will not affect any other provision hereof, and the Parties will negotiate in good faith to modify this Agreement to preserve (to the extent possible) their original
intent. 

  
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AS AMENDED. 
  

 13.17 Payment Floor. Except as permitted by Section 12.6, Section 10.6
of any License Agreement or Section 17.6 of any Co-Development, Co-Promote and Profit Share Agreement, in no event will any credits permitted to be taken by Celgene under this Agreement or any Development & Commercialization Agreement
against any particular Milestone Payment, royalty payment or Profit & Loss Share payment owed to Bluebird under any Development & Commercialization Agreement act to reduce such payment by more than [***] than would otherwise be
payable to Bluebird thereunder or thereunder (and for clarity “otherwise payable” above means that (i) any reductions pursuant to Section 10.3(c) of any License Agreement or Section 17.3 of any Co-Development, Co-Promote and
Profit Share Agreement will be made before determining the [***] floor specified above, but (ii) any royalty reductions pursuant to Section 4.3(d) of any License Agreement or Section 11.3(d) of any Co-Development, Co-Promote and
Profit Share Agreement will be included in calculating the up to [***] reduction permitted above). 
 13.18 Entire
Agreement. This Agreement is the sole agreement with respect to the subject matter and supersedes all other agreements and understandings between the Parties with respect to same (including the Confidential Agreement). 

[Remainder of this Page Intentionally Left Blank] 

  
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AS AMENDED. 
  

 IN WITNESS WHEREOF, the Parties have caused this Master Collaboration Agreement to be
executed by their respective duly authorized officers as of the Effective Date. 
  

			
	BLUEBIRD BIO, INC.
		
	By:	 	 /s/ Nick Leschly

		 	(Signature)
		
	Name:	 	 Nick Leschly

		
	Title:	 	 CEO

		
	Date:	 	 March 19, 2013

	
	CELGENE CORPORATION
		
	By:	 	 /s/ Perry Karsen

		 	(Signature)
		
	Name:	 	 Perry Karsen

		
	Title:	 	 COO

		
	Date:	 	 March 19, 2013

  
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AS AMENDED. 
  

 Exhibit A 
 License Agreement 

  

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AS AMENDED. 
  

 License Agreement 

by and between 
 bluebird bio, Inc. 
 and 

Celgene Corporation 
 [                    ] 

  

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AS AMENDED. 
  

 Table of Contents 

 

							
	 	 	 	  	Page	 
			
	 1.
	 	Definitions	  	 	1	  
			
	 2.
	 	Development and Commercialization	  	 	6	  
			
	 3.
	 	License Grants	  	 	10	  
			
	 4.
	 	Payments and Royalties	  	 	12	  
			
	 5.
	 	Ownership and Inventorship of IP	  	 	15	  
			
	 6.
	 	Patent Prosecution and Maintenance	  	 	16	  
			
	 7.
	 	Patent Enforcement and Defense	  	 	19	  
			
	 8.
	 	Confidentiality	  	 	19	  
			
	 9.
	 	Warranties; Limitations of Liability; Indemnification	  	 	19	  
			
	 10.
	 	Term and Termination	  	 	25	  
			
	 11.
	 	General Provisions	  	 	29	  

  

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AS AMENDED. 
  

 List of Appendices 

 

			
		
	 Appendix A
	 	Additional Definitions
		
	 Appendix B
	 	Applicable New In-Licenses
		
	 Appendix C
	 	Applicable Pre-Existing In-Licenses
		
	 Appendix D
	 	Certain Manufacturing Definitions
		
	 Appendix E
	 	Press Release
		
	 Appendix F
	 	 Certain Patents Within the Licensed IP
 as of the License Agreement Effective Date

		
	 Appendix G
	 	Bluebird Agreements
		
	 Schedule 9.2
	 	Exceptions to Bluebird’s Representations and Warranties

  

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AS AMENDED. 
  

 LICENSE AGREEMENT 

License Agreement 
 This License Agreement (this “License Agreement”), dated as of [            ] (the “License Agreement Effective
Date”), is made by and between bluebird bio, Inc., a Delaware corporation (“Bluebird”), and Celgene Corporation, a Delaware Corporation (“Celgene”). Each of Bluebird and Celgene may be referred to herein as
a “Party” or together as the “Parties.” 
 WHEREAS, Bluebird has developed and owns or has
rights to certain Patents and technology relating to developing innovative gene therapies for genetic disorders; 
 WHEREAS,
Celgene is a biopharmaceutical company focused on acquiring, Developing and Commercializing innovative anti-cancer agents; and 

WHEREAS, Bluebird and Celgene are parties to that certain Master Collaboration Agreement (dated
[            ], 2013) (the “Master Collaboration Agreement”) pursuant to which Celgene has an option to take a license to Product Candidates; 

WHEREAS, pursuant to the terms of the Master Collaboration Agreement, Celgene has exercised its option to select a Product Candidate to
be an Optioned Candidate by delivering to Bluebird a Celgene Option Notice and payment of the applicable Initial Option Fee and Additional Option Fee (such Optioned Candidate, as defined more fully in Appendix A, the “Elected
Candidate”); and 
 WHEREAS, the Parties now wish to enter into an exclusive licensing arrangement whereby Celgene will
have exclusive rights to Develop and Commercialize Licensed Product, all on the terms and conditions set forth here. 
 NOW,
THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the amount and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 

 

	1.	Definitions. 

 The following
terms and their correlatives will have the meanings set forth below. Capitalized terms used, but not defined, herein will have the meanings ascribed to such terms in the Master Collaboration Agreement. 

1.1 “Applicable Bluebird In-Licenses” means the Applicable Pre-Existing In-Licenses and the Applicable New In-Licenses.

 1.2 “Applicable New In-Licenses” means all New In-Licenses of Bluebird or its Affiliates necessary or useful
for the research, Development and/or Commercialization of Elected Candidate and Licensed Product that Celgene has elected to list on Appendix B as of the License Agreement Effective Date, plus any other New In-License of Bluebird or its
Affiliates that Celgene has elected to include as an Applicable New In-License pursuant to Section 3.2(b). 
 1.3
“Applicable Pre-Existing In-Licenses” means all Pre-Existing In-Licenses necessary or useful for the research, Development and/or Commercialization of Elected Candidate and Licensed Product, and any extensions or expansions of the
scope of such Pre-Existing In-Licenses, including those listed on Appendix C. 

  
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AS AMENDED. 
  

 1.4 “Biosimilar Product” means, with respect to a Licensed Product in
any country, any biosimilar product sold by a Third Party not authorized by or on behalf of Celgene, its Affiliates or Sublicensees, (i) that is a biosimilar biological product, as defined in 21 USC 379j-51 (or any successor or replacement
thereof), a similar biological medicinal product, as defined in Annex I to Directive 2001/83/EC (or any successor or replacement thereof), or any similar biosimilar or generic product under the Laws of any country or jurisdiction, or
(ii) regarding which Regulatory Approval is obtained by referencing Regulatory Data of such Licensed Product. 
 1.5
“Bluebird In-Licensed IP” means all Patents, Materials and Know-How in-licensed by Bluebird pursuant to Applicable Bluebird In-Licenses, including any extensions or expansions of the scope thereof. 

1.6 “Bluebird Technology” means all Bluebird Solely Owned IP and all of Bluebird’s right, title and interest in and
to Joint IP. 
 1.7 “Celgene Development & Commercialization Program” means a Development and
Commercialization program for Licensed Product in the Field worldwide. 
 1.8 “Celgene Licensed Product
In-License” means [***] 
 1.9 “Celgene Licensed Product In-Licensed IP” means [***] 

1.10 “Celgene Licensed Product IP” means [***] 
 1.11 “Celgene Other In-License” means [***] 
 1.12
“Celgene Regulatory Rights” means all Regulatory Data, Regulatory Filings and Regulatory Approvals for Elected Candidate and Licensed Product worldwide Controlled by Celgene or any of its Affiliates. 

1.13 “Celgene Technology” means all Celgene Solely Owned IP and all of Celgene’s right, title and interest in and
to Joint IP. 
 1.14 “Commercialization” means any and all activities directed to the Manufacturing, marketing,
detailing, promotion and securing of reimbursement of a product after Regulatory Approval has been obtained (including making, having made, using, importing, selling and offering for sale such product), and will include post-approval clinical
studies, post-launch marketing, promoting, detailing, marketing research, distributing, customer service, administering and commercially selling such product, importing, exporting or transporting such product for commercial sale, and all regulatory
compliance with respect to the foregoing. 
 1.15 “Commercially Reasonable Efforts” means, with respect to the
Development or Commercialization of Licensed Product by a Party, that level of efforts and resources that such Party would normally devote to the Development or Commercialization, as the case may be, of a product owned by it or to which it has
rights of the type it has hereunder, which is of a similar commercial potential at a similar stage in its lifecycle, in each case taking into account issues of safety and efficacy, product profile, the proprietary position, the then current
competitive environment for such product and the likely timing of such product’s entry into the market, the pricing and launching strategy for the respective product, the regulatory environment and status of such product, and other relevant
scientific, technical and commercial factors. 

  
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AS AMENDED. 
  

 1.16 “Control” or “Controlled” means, with respect to
any Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals, the possession (whether by ownership or license, other than by a license or sublicense granted pursuant to this License Agreement) by a Party or its
Affiliates of the ability to grant to the other Party a license or access as provided herein to such item, without violating the terms of any agreement or other arrangement with any Third Party or, other than under Applicable Bluebird In-Licenses,
being obligated to pay any royalties or other consideration therefor (“Additional Payments”). For clarity, Other In-Licenses are not “Controlled” for purposes of this License Agreement, unless and only after such Other
In-License is converted into an Applicable New In-License pursuant to Section 3.2(b). Notwithstanding the foregoing, as provided in Section 3.2(a), if on or after the License Agreement Effective Date and for such time as the other Party
agrees to pay and does in fact pay all Additional Payments with respect to such Party’s access or license to any Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals (other than that in-licensed by Bluebird
pursuant to an Other In-License), such Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals will be deemed to be included in the definition of “Control”. 

1.17 “Covers”, with reference to (i) a Patent, means that the making, using, selling, offering for sale or
importing of a product or practice of a method would infringe a Valid Claim of such Patent in the country in which such activity occurs, and (ii) Materials or Know-How, means that the Manufacture, Development or Commercialization of a product
incorporates, embodies or otherwise makes use of such Materials or Know-How. 
 1.18 “EU” means the
organization of member states of the European Union as it may be constituted from time to time. 
 1.19 “EU Regulatory
Event” means, with respect to a Licensed Product, the earlier to occur of [***] 
 1.20 “First Commercial
Sale” means [***] 
 1.21 “First Indication” means the [***] 

1.22 “GAAP” means U.S. generally accepted accounting principles or International Financial Reporting Standards,
consistently applied, as designated and used by the applicable Party. 
 1.23 “In-License Payments” means any
amounts paid or payable under any Applicable Bluebird In-License that are incurred by Bluebird solely and directly as a result of the grant of a sublicense thereunder under this License Agreement to Celgene, any of Celgene’s contract Third
Parties under Section 3.5, or any further Sublicensees of Celgene (including of Celgene’s Affiliates that are granted sublicenses) under this License Agreement. Any such payments will include [***] but excluding [***] 

1.24 “Licensed IP” means all (i) Patents, Materials and Know-How Controlled at any time during the term of this
License Agreement by Bluebird or any of its Affiliates (including any applicable Collaboration IP and Bluebird Technology), other than pursuant to an Applicable Bluebird In-License, and (ii) Bluebird In-Licensed IP, in each case to the extent
necessary or useful to Develop Elected Candidate and Develop and Commercialize Licensed Product. 

  
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AS AMENDED. 
  

 1.25 “Licensed Product” means any product that constitutes or
incorporates an Elected Candidate (including all modified and improved versions thereof), in all forms, presentations, and formulations (including manner of delivery and dosage). A modified or improved version of an Elected Candidate constituted or
incorporated in a product will be deemed a “Modified Licensed Product” for purposes of Section 4.2 if it is Covered by patentable technology Controlled by Bluebird that (i) is first discovered, created, conceived,
developed or reduced to practice after the later of (a) the License Agreement Effective Date and (b) the end of the Collaboration Program Term, (ii) requires the submission of a new BLA with respect to such modified or improved
Elected Candidate, and (iii) materially contributes to the Elected Candidate being approved for a new indication or new patient population. For clarity, “Modified Licensed Products” are Licensed Products hereunder for all purposes
other than Section 4.2. 
 1.26 “Manufacturing” means the production, manufacture, processing, filling,
finishing, packaging, labeling, shipping and holding of product or any intermediate thereof, including process development, process qualification and validation, scale-up, commercial manufacture and analytic development, product characterization,
stability testing, quality assurance and quality control. With reference to Elected Candidate and Licensed Product, Manufacturing includes Vector and associated Payload supply. 

1.27 “Net Sales” means [***] 
 1.28 “Pivotal Study” means (i) a Phase 3 Study that is intended by Celgene to be submitted (together with any other registration trials that are prospectively planned when such Phase
3 Study is initiated) for Regulatory Approval in the U.S. or the EU, or (ii) any other clinical study that is designed to establish that a pharmaceutical product is safe and efficacious for its intended use, and to determine warnings,
precautions, and adverse reactions that are associated with such pharmaceutical product in the dosage range to be prescribed, which clinical study is a registration trial intended to be sufficient for filing an application for a Regulatory Approval
for the Licensed Product in the U.S. or another country or some or all of an extra-national territory, solely as evidenced by the acceptance for filing for a Regulatory Approval for such product after completion of such study. 

1.29 “Regulatory Exclusivity Period” means with respect to a Licensed Product in a country, the period of time during
which (a) Celgene or any of its Affiliates or Sublicensees has been granted the exclusive legal right by a Regulatory Authority (or is otherwise entitled to the exclusive legal right by operation of Law) in such country to market and sell the
Licensed Product, or (b) the data and information submitted by Celgene or any of its Affiliates or Sublicensees to the relevant Regulatory Authority in such country for purposes of obtaining Regulatory Approval may not be disclosed, referenced
or relied upon in any way by such Regulatory Authority (including by relying upon the Regulatory Authority’s previous findings regarding the safety or effectiveness of the Licensed Product) to support the Regulatory Approval or marketing of any
product by a Third Party in such country. 
 1.30 “Second Indication” means a [***] 

1.31 “Selling Party” means Celgene and its Sublicensees (including Celgene’s Affiliates that are granted
sublicenses pursuant to Section 3.3 ). 

  
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AS AMENDED. 
  

 1.32 “Sublicensee” means any person or entity (including Affiliates of
Celgene) that is granted a sublicense as permitted by Section 3.3 (or an option to take such a sublicense), either directly by Celgene or indirectly by any other Sublicensee hereunder. 

1.33 “Valid Claim” means, with respect to a particular country, (i) any claim of an issued and unexpired Patent in
such country that (a) has not been held revoked, unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction, which decision is unappealable or unappealed within the time allowed for appeal and
(b) has not been abandoned, disclaimed, denied or admitted to be invalid or unenforceable through reissue or disclaimer or otherwise in such country, or (ii) a claim of a pending Patent application that has not been finally abandoned or
finally rejected or expired and which has been pending [***] from the date of filing of the earliest priority Patent application to which such pending Patent application is entitled to claim benefit. 

1.34 “Vector Supplies” means supplies of Vectors and associated Payloads Manufactured for incorporation into Elected
Candidate and Licensed Product for Development or Commercialization thereof. 
 Definitions for each of the following terms are found in the
body of this License Agreement or the Appendices hereto as indicated below: 
  

			
	 Defined Terms
	 	 Location

	Additional IP	 	Section 3.2(a)
	Allocable Manufacturing Overhead	 	Appendix D
	[***]	 	
	Biosimilar Product Competition	 	Section 4.3(e)
	Bluebird Indemnitees	 	Section 9.6(a)
	Business Acquisition	 	Section 3.4
	Business Party	 	Section 3.4
	Business Program	 	Section 3.4
	Celgene Indemnitees	 	Section 9.6(b)
	Commercial Supplies	 	Appendix D
	Competitive Infringement	 	Section 7.1
	Elected Candidate	 	Appendix A
	Fully Burdened Manufacturing Cost	 	Appendix D
	Indemnification Claim Notice	 	Section 9.6(c)
	Indemnified Party	 	Section 9.6(c)
	Joint IP	 	Section 5.2
	License Agreement Term	 	Section 10.1
	Losses	 	Section 9.6(a)
	Major EU Countries	 	Section 1.18
	Manufacturing and Supply Agreement	 	Section 2.4(c)(ii)
	Milestone Event	 	Section 4.2
	Milestone Payment	 	Section 4.2

  
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AS AMENDED. 
  

			
	 Defined Terms
	 	 Location

	Modified Licensed Product	 	Section 1.21
	[***]	 	
	Solely Owned IP	 	Section 5.1
	Third Party Claims	 	Section 9.6(a)

  

	2.	Development and Commercialization. 

 2.1 Development. As of and after the License Agreement Effective Date, Celgene will assume sole responsibility for, and control of, Developing Elected Candidate and Licensed Product in the Field
worldwide, and will establish a Celgene Development & Commercialization Program for that purpose. As of and after the License Agreement Effective Date, Celgene will have sole responsibility for all costs and expenses arising from the
Development and Commercialization of Elected Candidate and Licensed Product in the Field worldwide. Notwithstanding the foregoing, if the initial Phase 1 Study with respect to Optioned Candidate has not been completed as of the License Agreement
Effective Date, at Celgene’s election, Bluebird will continue to be responsible for the performance of such initial Phase 1 Study under the oversight of the JSC under the Master Collaboration Agreement until completion of such initial Phase 1
Study. In the event Bluebird continues, at Celgene’s election, to continue to be responsible for the performance of such initial Phase 1 Study, Bluebird will be responsible for the costs of performing such initial Phase 1 Study until the
earlier to occur of (i) completion of such initial Phase 1 Study and (ii) expiration or termination of the Collaboration Program Term; following the end of the Collaboration Program Term, Celgene will reimburse Bluebird for the
out-of-pocket costs of performing such initial Phase 1 Study incurred after the end of the Collaboration Program Term within thirty (30) days of Celgene’s receipt of Bluebird’s written invoice therefor. 

2.2 Regulatory. Subject to the last sentence of Section 2.1, (i) as of and after the License Agreement Effective Date,
Celgene will lead and have sole control of all efforts with Regulatory Authorities regarding the Development and Commercialization of Elected Candidate and Licensed Product in the Field worldwide, including taking full responsibility for preparing
and filing the relevant Regulatory Filings and seeking Regulatory Approval and (ii) promptly following the License Agreement Effective Date, Bluebird will, at Celgene’s expense, assign to Celgene all Regulatory Filings with respect to
Elected Candidate and Licensed Product. For clarity, in the event Bluebird continues to be responsible for the performance of an initial Phase 1 Study following the License Agreement Effective Date in accordance with Section 2.1, Bluebird will
retain ownership of any Regulatory Filings (including the IND) for Optioned Candidate until completion of such initial Phase 1 Study. In the event of failure to assign such Regulatory Filings to Celgene, Bluebird hereby consents and grants to
Celgene the right to access and reference (without any further action required on the part of Bluebird, whose authorization to file this consent with any Regulatory Authority is hereby granted) any such Regulatory Filing. 

2.3 Technical Assistance. During the Collaboration Program Term, Bluebird will reasonably cooperate with Celgene to provide all
technical assistance, and to transfer to Celgene any additional Know-How licensed to Celgene under Section 3.1, requested by Celgene to facilitate the transfer of Development efforts related to Elected Candidate and Licensed Product.

  
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AS AMENDED. 
  

 
Such cooperation will include providing Celgene with reasonable access by teleconference or in-person at Bluebird’s facilities to Bluebird personnel involved in the research and Development
of Elected Candidate to provide Celgene with a reasonable level of technical assistance and consultation in connection with the transfer of such Know-How. Following the Collaboration Program Term, Bluebird will reasonably cooperate with Celgene to
provide reasonable amounts of technical assistance, including to transfer to Celgene any additional Know-How licensed to Celgene under Section 3.1, with respect to Elected Candidate or Licensed Product as reasonably requested by Celgene with
reasonable advance notice to Bluebird. Any dispute with respect to the amount and completeness of the technical assistance and cooperation to be provided by Bluebird under this Section 2.3 will be referred to and finally resolved by binding
arbitration by a mutually agreeable, disinterested, conflict-of-interest-free individual not affiliated or consulting with either Party. Any such arbitration will be conducted under the then-current rules of the American Arbitration Association.

 2.4 Manufacture and Supply. 
 (a) Manufacturing. Subject to Section 2.4(b), Celgene will be solely responsible for, and will bear all the costs and expenses of, Manufacturing and supplying all Elected Candidate and
Licensed Product for Development and Commercialization in the Field worldwide and, subject to Section 2.4(c), Celgene will purchase Vector Supply from Bluebird or its designee for such purpose. 

(b) Vector Supply. Bluebird will have the sole right to Manufacture or have Manufactured Vector Supply, and Celgene will have no
rights with respect thereto except as provided in Section 2.4(c)(iv). Except as provided in Section 2.4(c)(iv) or in the Manufacturing Supply Agreement, neither Celgene nor any Affiliate of Celgene (nor any others on behalf of or under
license or sublicense from Celgene or any of its Affiliates) will Manufacture (i) any Vector and associated Payload for Licensed Product or (ii) Licensed Product, except for the Manufacture of Licensed Product using Vector Supply supplied
by or on behalf of Bluebird. Except as provided in Section 2.4(c)(iv) or in the Manufacturing Supply Agreement, Celgene and its Affiliates and Sublicensees will purchase all Vector Supply exclusively from Bluebird or its designee. 

(c) Vector Supply Terms. 
 (i) Except as provided otherwise in this Section 2.4(c) or in the Manufacturing Supply Agreement, Bluebird and its Affiliates will Manufacture, or cause a Third Party to Manufacture, all Vector
Supply for all Elected Candidate and Licensed Product required for clinical Development and Commercialization in the Field worldwide, and will have the right to make all necessary decisions regarding arrangements with Third Party manufacturers,
provided that Bluebird will reasonably consult with Celgene with respect to all such arrangements and obtain Celgene’s prior written consent, which will not be unreasonably withheld, conditioned or delayed. [***] 

(ii) The Parties will enter into a “Manufacturing and Supply Agreement,” between each other or among the Parties and an
Affiliate or a Third Party, covering Vector Supply as soon as reasonably practicable after the License Agreement Effective Date, which agreement will be consistent with and supersede the terms of this Section 2.4(c) and will otherwise be
subject in all respects to the terms and conditions of this License Agreement. 

  
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AS AMENDED. 
  

 (iii) The cost to Celgene of Vector Supply will equal [***] of Bluebird’s Fully
Burdened Manufacturing Cost for such Manufacture, plus [***], unless otherwise agreed by the Parties in writing. 
 (iv) The
Manufacturing and Supply Agreement will include the terms set forth in Appendix H, including terms permitting Celgene to establish “back-up” and/or “second source” rights for Vector Supply and license grants from Celgene
to Bluebird under the Celgene Licensed Product IP and Celgene Licensed Product In-Licensed IP to the extent necessary or useful for Bluebird to Manufacture Vector Supply. [***] 

(v) At Celgene’s request, Bluebird will cooperate with Celgene’s reasonable requests, at Celgene’s cost and expense, to
engage in a technology transfer to allow Celgene, in accordance with Section 2.4(c)(iv), to Manufacture Vector Supply (through the first commercial batch of Vector Supply) itself or by through its designated Third Party manufacturer, by
transferring all Know-How, Materials, technology and trade secrets Controlled by Bluebird or its Affiliates that are necessary to Manufacture Vector Supply, thereby enabling Celgene (or such Third Party) to Manufacture the Vector Supply. 

(vi) Any purchase of Vector Supply from Bluebird or its designee will expressly not include any license rights to any Know-How or
Patents, but instead all licenses (implied, by exhaustion or otherwise) will arise under Section 3.1, if and as applicable. 
 (vii) For the purpose of this License Agreement, certain words and phrases (and their correlatives) relating to Manufacturing will have the meanings set forth on Appendix D. 

2.5 Celgene Diligence. Celgene, directly or through one or more of its Sublicensees, will use Commercially Reasonable Efforts:
(i) to Develop Licensed Product in the Field and to obtain Regulatory Approvals therefor; and (ii) to Commercialize Licensed Product in the Field after obtaining such Regulatory Approval, in each country worldwide where Commercializing
Licensed Product would be warranted by using Commercially Reasonable Efforts. 
 2.6 Annual Update Meetings. At least
once during each consecutive twelve (12)-month period from the License Agreement Effective Date until the earlier of first approval of a BLA for Licensed Product by the FDA or first approval of an MAA for Licensed Product by the EMA, within thirty
(30) days of Bluebird’s written request, the Parties will meet in person at a U.S. site of Celgene for Celgene to provide Bluebird with an update on the Development of Licensed Product by Celgene and its Sublicensees. During such meeting,
Celgene will disclose to Bluebird all material information regarding such Development. 
 2.7 Reports by Celgene. Celgene
will prepare and maintain, and will cause its Sublicensees to prepare and maintain, reasonably complete and accurate records regarding the Development of Elected Candidate and Licensed Product, and Commercialization of Licensed Product worldwide
after Regulatory Approval therefor. Celgene will provide to Bluebird a reasonably detailed report regarding such efforts at least once every twelve (12)-month period from the License Agreement Effective Date. Such report will contain sufficient
detail to enable Bluebird to assess Celgene’s compliance with its Development and Commercialization obligations in Section 2.5, including information with respect to the following: (i) the design,

  
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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
status and results of any animal studies and clinical trials for Licensed Product; (ii) any regulatory milestones, and any Regulatory Approvals achieved, for Licensed Product; and
(ii) activities with respect to selling, promoting, supporting, detailing and marketing of Licensed Product. In addition to the foregoing, Celgene will provide Bluebird with such additional information regarding any such activities as Bluebird
may reasonably request from time to time. 
 2.8 Applicable Bluebird In-Licenses and Other IP. 

(a) Maintenance of Applicable Bluebird In-Licenses. Bluebird (i) will duly perform and observe all of its obligations under
the Applicable Bluebird In-Licenses in all material respects and maintain in full force and effect the Applicable Bluebird In-Licenses, and (ii) will not, without Celgene’s prior written consent (such consent not to be unreasonably
withheld, conditioned or delayed), (1) amend, modify, restate, cancel, supplement or waive any provision of any Applicable Bluebird In-License, or grant any consent thereunder, or agree to do any of the foregoing, or (2) exercise any right
to terminate any Applicable Bluebird In-License in each case ((1) and (2)) that would reasonably be expected to adversely affect in any respect the rights of Celgene under this License Agreement, provided that Bluebird will provide prior
written notice to Celgene of all of the foregoing notwithstanding whether or not any of the foregoing would reasonably be expected to adversely affect in any respect the rights of Celgene under this License Agreement. Bluebird will provide Celgene
with written notice as promptly as practicable (and in any event within five (5) business days) after becoming aware of any of the following: (A) any material breach or default by Bluebird or any of its Affiliates of any covenant,
agreement or other provision of any Applicable Bluebird In-License, (B) any notice or claim from the counterparty to any Applicable Bluebird In-License terminating or providing notice of termination of any Applicable Bluebird In-License,
(C) any notice or claim alleging any breach of default under any Applicable Bluebird In-License, or (D) the existence of any facts, circumstances or events which alone or together with other facts, circumstances or events could reasonably
be expected (with or without the giving of notice or passage of time or both) to give rise to a breach of or default under or right to terminate any Applicable Bluebird In-License. If Bluebird fails to pay any amounts due under any Applicable
Bluebird In-License and if such nonpayment would permit the counterparty to such Applicable Bluebird In-License to terminate or suspend the same or any rights thereunder, Celgene will have the right, but not the obligation, in its sole discretion,
to pay such amounts on Bluebird’s behalf, and any amounts so paid by Celgene may be taken by Celgene as a credit against any amounts payable to Bluebird under this License Agreement. 

(b) [***] 
 (c)
Applicable Bluebird In-License Requirements. Celgene will abide, and will cause all its Affiliates and applicable Sublicensees to abide, by all requirements of each Applicable Bluebird In-License in all material respects (and in any case in
all respects in the case that failure to so abide would result in a breach under the Applicable Bluebird In-License), to the extent applicable to sublicensees thereunder and to the extent disclosed by Bluebird to Celgene, with the understanding that
disclosure by Bluebird of any Applicable Bluebird In-License to Celgene will be deemed disclosure of such requirements of such Applicable Bluebird In-License to Celgene. In the event of a termination of any Applicable Bluebird In-License, Bluebird
agrees, to the extent requested by Celgene, to reasonably assist Celgene in securing a direct license from 

  
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AS AMENDED. 
  

 
the applicable licensor under any Patents, Materials and Know-How that was licensed to Bluebird and sublicensed to Celgene hereunder prior to such termination. In addition, Bluebird agrees, if
requested by Celgene, to reasonably assist Celgene in securing a standby license from the applicable licensor under any Patents, Materials and Know-How that are licensed to Bluebird and sublicensed to Celgene. 

 

	3.	License Grants. 

3.1 License by Bluebird. Subject to the terms and conditions of this License Agreement, Bluebird hereby grants to Celgene a
worldwide, exclusive (even as to Bluebird) license, with the right to sublicense only as permitted by Section 3.4, under Licensed IP, to Develop Elected Candidate and to Develop and Commercialize Licensed Product. Further, (i) the license
to Commercialize granted in this Section 3.1 will cover only the sale and offer for sale of Licensed Product in finished form and not the sale or offer for sale of Vectors (other than as and to the extent incorporated in the Licensed Product),
and (ii) rights to Manufacture Vectors and associated Payloads are included within the scope of the license granted to Celgene under this Section 3.1, which rights are subject to the terms and conditions of Section 2.4(c). 

3.2 Additional IP; Other In-Licenses. 
 (a) Additional IP. Except as set forth in Section 3.2(b), Celgene may, on or after the License Agreement Effective Date, elect to include within the scope of the Licensed IP any Know-How,
Material, Patent, Regulatory Data, Regulatory Filings or Regulatory Approvals (“Additional IP”), that would be Controlled by Bluebird but for required payments of Additional Payments to a Third Party, by (i) providing notice to
Bluebird of same and (ii) agreeing to pay and in fact paying all Additional Payments with respect to Celgene’s access or license to such Additional IP. Following Bluebird’s receipt of such notice and subject to Celgene’s
performance of its obligations to pay any Additional Payments with respect to Celgene’s access or license to such Additional IP, such Additional IP will be deemed Licensed IP hereunder. For avoidance of doubt, this Section 3.2(a) does not
apply to Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals licensed to Bluebird under the Applicable Bluebird In-Licenses, all of which are deemed Controlled by Bluebird notwithstanding this
Section 3.2(a). 
 (b) Other In-Licenses. Celgene may, on or after the License Agreement Effective Date, elect to
convert any Other In-License to an Applicable New In-License by providing notice to Bluebird of same. Upon Bluebird’s receipt of such notice, such Other In-License will be an Applicable New In-License hereunder, Appendix B will
automatically be updated to include such New In-License and the provisions of this License Agreement applicable to New In-Licenses, including Section 4.1(b), will apply with respect to such New In-License. 

3.3 Sublicensing Rights. 
 (a) Transfer. The licenses granted in Sections 3.1 are transferable only upon a permitted assignment of this License Agreement in accordance with Section 11.12. 

(b) Celgene Sublicenses. The license granted in Section 3.1 may be sublicensed, in full or in part, by Celgene by a written
agreement to its Affiliates and Third Parties (with the right to sublicense through multiple tiers), provided, that as a condition precedent to and requirement of any such sublicense: 

(i) Celgene will provide Bluebird with a copy of any sublicense agreement with a non-Affiliated Sublicensee within thirty (30) days
of execution thereof, and to the extent permitted under any Applicable Bluebird In-License, such sublicense agreement may be redacted as necessary to protect commercially sensitive information; 

  
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AS AMENDED. 
  

 (ii) Celgene will be responsible for any and all obligations of such Sublicensee as if
such Sublicensee were “Celgene” hereunder; and 
 (iii) Any such Sublicensee will agree in writing to be bound by
substantially identical obligations as Celgene hereunder with respect to the activities of such Sublicensee hereunder (and not with respect to the activities of any other), including Know-How disclosure obligations Celgene has to Bluebird hereunder
with respect to the activities of such Sublicensee hereunder (but excluding payment obligations). 
 3.4 Exclusivity.
During the License Agreement Term, neither Party nor its Affiliates (nor any others on behalf of or with, or under license or sublicense from, such Party or any its Affiliates) will research, Develop, Manufacture or Commercialize any products
(including Vectors and associated Payloads) to be used in the Field (which, for the purposes of this Section 3.4, will include all indications and will not be limited to cancer) that specifically target the same Target Antigen as Elected
Candidate, other than pursuant to this License Agreement (which includes, for avoidance of doubt, research, development, Manufacture and Commercialization of improved and modified versions of the Licensed Product by Celgene) or any other
Development & Commercialization Agreement (if against the same Target Antigen) (which includes, for avoidance of doubt, research, development, Manufacture and Commercialization of improved and modified versions of the Licensed Product by
Celgene). Notwithstanding this Section 3.4, if (i) a Business Combination occurs with respect to either Party with a Third Party or (ii) a Party acquires a Third Party (including by a merger or consolidation) so that such Third Party
becomes an Affiliate over which the acquiring Party has control (as defined in the definition of Affiliate), or (iii) a Party acquires all or substantially all of the assets of a Third Party (including any Subsidiaries or divisions thereof)
(each of (i), (ii) and (iii), a “Business Acquisition”; such Party, the “Business Party”), and, in each case, the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such
Third Party or such Third Party’s Affiliates, other than the Business Party and its Affiliates as of the Business Acquisition) (a) already has, or the acquired assets contain, as applicable, a program that existed prior to, or was planned
prior to and is demonstrably to be implemented shortly after, the Business Acquisition or (b) initiates and pursues a new program following such Business Acquisition, in each case that would otherwise violate this Section 3.4 (a
“Business Program”), then such Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than the Business Party and its Affiliates as of
the Business Acquisition), as applicable, will be permitted to initiate, pursue and continue such Business Program after such Business Acquisition and such initiation, pursuit and continuation will not constitute a violation of this
Section 3.4; provided however that (1) none of the Licensed IP, or other Patents, Materials or Know-How Controlled by the other Party and, in each case, licensed to the Business Party will be used in the Business Program, and (2) the
research or Development activities required under this License Agreement will be conducted separately from any research or Development activities directed to such Business Program, including the maintenance of separate

  
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AS AMENDED. 
  

 
lab notebooks and records (password-protected to the extent kept on a computer network) and separate personnel working on each of the activities under this License Agreement and the activities
covered under such Business Program. 
 3.5 Contract Manufacturers. Subject to the terms and conditions of this License
Agreement, Celgene will have the right to appoint by a written agreement “contract manufacturers”, meaning any Third Party or Affiliate of Celgene that manufactures Licensed Product (or components therefor) for re-sale, but who itself is
not a “Sublicensee” hereunder and thereby exercises “have made” rights granted by Bluebird under Section 3.1, as well as “contract research organizations” and other providers performing services on Celgene’s
behalf, none of which will be deemed a “Sublicensee” hereunder. Celgene will be responsible for any such contract manufacturer, contract research organization or service provider hereunder, and further will require any such contract
manufacturer, contract research organization or service provider to agree in writing to comply with Sections 3.6 and 8. 
 3.6
No Implied Rights. No license, sublicense or other right is or will be created or granted hereunder by implication, estoppel or otherwise. Any licenses, sublicenses or rights will be granted only as expressly provided in this License
Agreement. Celgene will not practice or otherwise use any Licensed IP other than in accordance with the licenses granted in Section 3.1. 
 3.7 Section 365(n) of the Bankruptcy Code. All rights and licenses granted pursuant to any section of this License Agreement are, and will be deemed to be, rights and licenses to
“intellectual property” (as defined in Section 101(35A) of title 11 of the United States Code and of any similar provisions of applicable Laws under any other jurisdiction (the “Bankruptcy Code”)). Bluebird agrees
that Celgene, as a licensee of rights and licenses under this License Agreement, will retain and may fully exercise all of its rights and elections under the Bankruptcy Code. The Parties further agree that, in the event of the commencement of a
bankruptcy proceeding by or against Bluebird under the Bankruptcy Code or analogous provisions of applicable Law outside the United States, Celgene will be entitled to a complete duplicate of (or complete access to, as appropriate) any intellectual
property licensed to Celgene and all embodiments of such intellectual property, which, if not already in Celgene’s possession, will be promptly delivered to it (i) upon any such commencement of a bankruptcy proceeding upon Celgene’s
written request therefor, unless Bluebird elects to continue to perform all of its obligations under this License Agreement or (ii) if not delivered under clause (i), following the rejection of this License Agreement by Bluebird in the
bankruptcy proceeding upon written request therefor by Celgene. 
  

	4.	Payments and Royalties. 

 4.1 Applicable Bluebird In-Licenses and Celgene Licensed Product In-Licenses. 
 (a) Applicable Pre-Existing In-Licenses. If any In-License Payment becomes due under any Applicable Pre-Existing In-License during the License Agreement Term, Bluebird will pay same, provided that
Celgene will reimburse Bluebird for any such In-License Payment within thirty (30) days of Celgene’s receipt of Bluebird’s written invoice therefor, which In-License Payment (other than payments that are royalties) will not exceed
[***], and subject to Section 6.1. Any such reimbursement by Celgene to Bluebird (1) is in addition to and not in lieu of the other payments required by this Section 4 and (2) will not be subject to Section 4.3(d). [***]

  
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AS AMENDED. 
  

 (b) Applicable New In-Licenses. Celgene may elect to take a sublicense under any
New In-License of Bluebird and its Affiliates and upon such election, such New In-License will be an Applicable New In-License hereunder for all purposes. For the purposes of determining the Parties’ respective payment obligations, all
Applicable New In-Licenses as of and following the License Agreement Effective Date will be listed on Appendix B. If any In-License Payment becomes due under any Applicable New In-License during the License Agreement Term, Bluebird will pay
same and, subject to Section 6.1, Celgene will reimburse Bluebird for (i) [***] of such payment that are royalties, which royalties will be subject to Section 4.3(d), and (ii) [***] of such payment that are not royalties, in each
case ((i) and (ii)) within thirty (30) days of receipt of Bluebird’s written invoice therefor. If Celgene elects to convert an Other In-License to an Applicable In-License pursuant to Section 3.2(b), Celgene will reimburse Bluebird
for [***] of any In-License Payments that became due under such Applicable New In-License during the License Agreement Term to the same extent as if such Applicable New In-License was designated as such as of the License Agreement Effective Date,
including with respect to applicable Patent Costs in accordance with Section 6.1, provided that Bluebird provides Celgene with a reasonable accounting of same. If any In-License Payments are royalties due under any Applicable New In-License
during the License Agreement Term, such royalties will be subject to Section 4.3(d). To the extent that any grant of a sublicense by Celgene or any Sublicensees under an Applicable New In-License triggers a payment obligation under such
Applicable New In-License, Bluebird will pay same and Celgene will reimburse Bluebird for [***] of such payment within thirty (30) days of receipt of Bluebird’s written invoice therefor. 

(c) Celgene Licensed Product In-Licenses. If any payments become due under any Celgene Licensed Product In-License with respect to
the Licensed Product, Bluebird will be responsible for [***] of such payments as provided in Section 4.1(e) of the Master Collaboration Agreement, provided that if any such payments are royalties, such royalties will be subject to
Section 4.3(d). 
 4.2 Milestone Payments. Celgene will make milestone payments (each, a “Milestone
Payment”) to Bluebird upon the occurrence of each of the milestones events (each, a “Milestone Event”) as set forth below in this Section 4.2. Each of the Milestone Payments will be payable to Bluebird by Celgene
within forty-five (45) days of the achievement of the specified Milestone Event, and such payments when owed or paid will be non-refundable and non-creditable, and not subject to set-off, except as otherwise set forth in Sections 2.8(a),
10.3(c) and 10.6 hereof, and Sections 4.1(e), 4.3 and 12.6 of the Master Collaboration Agreement. Except with respect to Modified Licensed Products, each of the Milestone Payments are payable only once in total under this License Agreement, whether
achieved by one or more Licensed Products. Notwithstanding the foregoing, Bluebird will be entitled to receive [***] of the Milestone Payments below, other than the Milestone Payment for the first Milestone Event (i.e., [***]. 

 

			
	 Milestone Event
	 	 Milestone Payment

	[***]	 	
		
	[***]	 	

  
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AS AMENDED. 
  

 4.3 Royalties. 

(a) Rates. Subject to the remainder of this Section 4.3, Celgene will pay to Bluebird running royalties, on a Licensed
Product-by-Licensed Product basis, based on the total aggregate annual Net Sales worldwide by Selling Parties of such Licensed Product in a given calendar year at the following royalty rates: 

 

			
	 Annual Worldwide Net Sales

of each Licensed Product
	 	 Royalty Rate

	[***]	 	

 By way of example, in a given calendar year, if the aggregate annual worldwide Net Sales for a Licensed Product is [***],
the following royalty payment would be payable for those Net Sales under this Section 4.3(a): [***] 
 (b) Royalty
Term. Royalties under Section 4.3(a) will be payable, on a Licensed Product-by-Licensed Product and country-by-country basis, on the Net Sales of any Licensed Product if at least one of the following two (2) conditions apply: [***]

 (c) Royalty Reduction. If Licensed Product is royalty-bearing only on account of Section 4.3(b)(ii), then the
royalty rates set forth in Section 4.3(a) with respect to Net Sales attributable to Licensed Product will be reduced by [***]. 
 (d) Third Party Royalty Payments. If Celgene or its Sublicensee, in its reasonable judgment, is required to obtain a license from any Third Party under any Patent Covering Licensed Product in order
to Develop or Commercialize such Licensed Product, and if Celgene (or its Sublicensee) is required to pay to such Third Party under such license any royalties, and the infringement of such Patent cannot reasonably be avoided by Celgene (or its
Sublicensee), or if Celgene (or its Sublicensee) is required by a court of competent jurisdiction to pay royalties or lost profits to such a Third Party (and the infringement of such Patent cannot reasonably be avoided), then the amount of
Celgene’s royalty obligations under this Section 4.3 will be reduced by [***] of the amount of such royalties paid to such Third Party, provided however, that the royalties payable under Section 4.3(a) will not be reduced in any such
event below [***] of the amounts set forth in Section 4.3(a) (but as may be further reduced pursuant to Section 4.3(c) or Section 4.3(e)) for each royalty tier. Any royalties payable under any Applicable Pre-Existing In-Licenses may
not be deducted under this Section 4.3(d) from royalties owed to Bluebird. Any royalties payable under any Applicable New In-Licenses and Celgene Licensed Product In-Licenses may be deducted under this Section 4.3(d) from royalties owed to
Bluebird. Celgene (or its Sublicensee) will use its commercially reasonable efforts to minimize the amount of any of the foregoing payments owed to Third Parties. Prior to Celgene or its Sublicensee exercising its reasonable judgment under this
Section 4.3(d), Celgene will provide Bluebird with written notice of a potential need to obtain any license from Third Parties. The Parties will discuss the best course of action to resolve such potential license requirement(s). 

(e) [***] 
 (f)
Additional Royalty Provisions. The royalties payable under Section 4.3(a) will be subject to the following: 
 (i)
only one royalty will be payable hereunder with respect to each Licensed Product unit; 

  
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AS AMENDED. 
  

 (ii) royalties when owed or paid hereunder will, except as provided in
Section 4.3(d), be non-refundable and non-creditable and not subject to set-off (except as otherwise provided in Sections 2.8(a), 10.3(c) and 10.6 hereof, [***] and 17.6 of any Co-Development, Co-Promote and Profit Share Agreement, and Sections
4.1(e), 4.3 and 12.6 of the Master Collaboration Agreement); and 
 (iii) except as expressly set forth in Sections 4.3(c),
4.3(d) and 4.3(e), no other royalty deductions are permitted hereunder. 
 4.4 Payment Terms. [***] 

(h) Mutual Convenience of the Parties. The royalty and other payment obligations set forth hereunder have been agreed to by the
Parties for the purpose of reflecting and advancing their mutual convenience, including the ease of calculating and paying royalties and other amounts to Bluebird. 
  

	5.	 Ownership and Inventorship of IP. 

 5.1 Solely-Owned IP. Subject to Section 5.2, as between the Parties, each Party will own and retain all right, title and interest in and to any and all Know-How and Patents arising therefrom
that are discovered, created, conceived, developed or reduced to practice solely by or on behalf of such Party under or in connection with this License Agreement, including as part the Celgene Development & Commercialization Program
(“Solely Owned IP”). Subject to the licenses hereunder and the other terms and conditions of this License Agreement, each Party will be solely responsible for the Prosecution and Maintenance, and the enforcement and defense, of any
Patents within its Solely Owned IP, and the other Party will have no rights with respect thereto. 
 5.2 Joint IP. The
Parties will jointly own any and all Know-How and Patents arising therefrom that are discovered, created, conceived, developed or reduced to practice jointly by or on behalf of the Parties, under or in connection with this License Agreement,
including as part of the Celgene Development & Commercialization Program (“Joint IP”). Each Party will have an undivided one-half interest in and to Joint IP. Each Party will exercise its ownership rights in and to such
Joint IP, including the right to license and sublicense or otherwise to exploit, transfer or encumber its ownership interest, without an accounting or obligation to, or consent required from, the other Party, but subject to the licenses hereunder
and the other terms and conditions of this License Agreement, including Section 3.4. At the reasonable written request of a Party, the other Party will in writing grant such consents and confirm that no such accounting is required to effect the
foregoing regarding Joint IP. Each Party, for itself and on behalf of its Affiliates, licensees and sublicenses, and employees, subcontractors, consultants and agents of any of the foregoing, hereby assigns (and to the extent such assignment can
only be made in the future hereby agrees to assign), to the other Party a joint and undivided interest in and to all Joint IP. The Prosecution and Maintenance, and the enforcement and defense, of any Patents within Joint IP will be jointly managed
by the Parties on mutually agreeable terms to be entered into by the Parties at the time any such Patents are first filed, provided that (i) all recoveries and Patent 

  
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AS AMENDED. 
  

 
Costs arising from the enforcement or defense of any Patents within Joint IP, absent further agreement, will be shared by the Parties in accordance with Section 7.2(e) (provided that
sufficient advance written notice of any such Patent Costs is given to the Party not incurring same) and (ii) Patent Costs incurred in connection with the Prosecution and Maintenance of Patents within Joint IP will be apportioned as set forth
in Sections 6.1 and 6.3, provided that in each case ((i) and (ii)), if either Party elects not to pay any such Patent Costs for any such Patent, the Parties will meet and agree upon an equitable way to treat such Patent. 

5.3 Inventorship. Inventorship determination for all Patents worldwide arising from any Know-How created, conceived or developed
by or on behalf of the Parties under or in connection with this License Agreement and thus the ownership thereof will be made in accordance with applicable United States patent Laws. 

5.4 Allocation. Notwithstanding Sections 5.1 – 5.3, the Patent Committee may allocate ownership of a particular item of
intellectual property to improve the prospects of obtaining patent protection with respect to such item of intellectual property, even if such allocation is not in accordance with the terms of Sections 5.1 – 5.3, so long as the Parties mutually
agree to such allocation. 
  

	6.	Patent Prosecution and Maintenance. 

 6.1 Generally. Subject to Sections 6.2 and 6.3, Bluebird will have the sole right to Prosecute and Maintain Patents within the Licensed IP. Bluebird will use commercially reasonable efforts
to, where applicable and upon Celgene’s reasonable request, separate parent Patent applications within the Licensed IP into one or more separate Patent applications for Specific Patents, to the extent permitted under applicable Law, where doing
so would not reasonably be expected to materially harm any Patent within the Licensed IP or other Patents owned by Bluebird or its Affiliates, provided that the foregoing limitation will not apply to Licensed IP that is Collaboration IP. [***]

 6.2 Celgene Input. Bluebird will regularly provide Celgene with copies of all applications for Patents within the
Licensed IP, and all other material submissions and correspondence with any patent authorities regarding such Patents, in sufficient time to allow for review and comment by Celgene. In addition, Bluebird will provide Celgene and its counsel with an
opportunity to consult with Bluebird and its counsel regarding Prosecution and Maintenance of any such Patents in the Field, and Bluebird will consider in good faith all comments timely made by Celgene and its counsel. In the event of any
disagreement between any of Bluebird or Celgene, Bluebird will have the final decision-making authority with respect to the matter involved as long as Bluebird acts in good faith. 

6.3 Specific Patents. For any Patent within the Licensed IP [***] (each “Specific Patent”), the following will
apply: upon Celgene’s written request, and provided that Bluebird reasonably agrees with Celgene that the following Prosecution and Maintenance activities would not materially harm any other Patent within the Licensed IP or other Patents owned
by Bluebird or its Affiliates (other than Collaboration IP), Celgene will control the Prosecution and Maintenance of the Specific Patents, and notwithstanding anything in Section 6.1 to the contrary, Celgene will be solely responsible for the
payment of all related Patent Costs. In addition, Celgene will provide Bluebird and its counsel with an opportunity to consult with Celgene and 

  
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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
its counsel regarding Prosecution and Maintenance of any such Specific Patents, and Celgene will include or reflect all reasonable comments timely made by Bluebird and its counsel. Celgene
acknowledges and agrees that Bluebird may grant similar rights to other exclusive Third Party licensees under any Patent within the Licensed IP that has claims Covering only a product that is not a Licensed Product (or its manufacture or use) and no
other product (or its manufacture or use), other than Specific Patents. If the Parties cannot agree whether or not any Patent within the Licensed IP is a Specific Patent, or if Bluebird claims that the foregoing Prosecution and Maintenance
activities would materially harm any other Patent within the Licensed IP or other Patents owned by Bluebird or any of its Affiliates, either of the Parties may refer such dispute to a mutually agreeable, disinterested, conflict-of-interest-free
individual not affiliated or consulting with either Party and who has at least fifteen (15) years of patent prosecution experience in the pharmaceutical field. Any such arbitration will be conducted under the then-current rules of the American
Arbitration Association, and the decision of the arbitrator will be final. 
 6.4 Election Not to
Prosecute or Maintain or Pay Patent Costs. If Bluebird elects not (i) to Prosecute or Maintain any Patents within the Licensed IP in any particular country before the applicable filing deadline or continue such activities once filed in a
particular country, or (ii) to pay the Patent Costs associated with Prosecution or Maintenance of any Patents within the Licensed IP, then in each such case Bluebird will so notify Celgene, promptly in writing and in good time to enable
Bluebird to meet any deadlines by which an action must be taken to preserve such Patent in such country, if Celgene so requests. Upon receipt of each such notice by Bluebird, Celgene will have the right, but not the obligation, to notify Bluebird in
writing on a timely basis that Celgene will assume control of the Prosecution or Maintenance of such Patent, and bear the Patent Costs thereafter incurred by Celgene with respect thereto. In addition, Celgene will provide Bluebird and its counsel
with an opportunity to consult with Celgene and its counsel regarding Prosecution and Maintenance of any such Patents, and Celgene will include or reflect all reasonable comments timely made by Bluebird and its counsel. If after making such
election, Celgene elects not to pay the Patent Costs associated with Prosecution or Maintenance of any such Patent, then in each such case Celgene will so notify Bluebird and on the ninetieth (90th) day after Bluebird’s receipt of such notice such Patent
will no longer be licensed to Celgene hereunder and will no longer be included within the “Licensed IP” hereunder. 

6.5 Third Party Rights. To the extent that a Third Party licensor of Bluebird has retained any right to Prosecute or Maintain any
Patent within the Licensed IP licensed to Celgene hereunder (including pursuant to an Applicable Bluebird In-License), or otherwise be involved in such activities, Bluebird will use commercially reasonable efforts to cause such Third Party licensor
to take the actions specified by this Section 6 (including Sections 6.6 and 6.7) in a manner consistent with the in-license applicable thereto, but Bluebird will not be deemed to be in breach of its obligations under this Section 6 if,
after using such commercially reasonable efforts, it is unable to comply with such obligations because of actions taken or not taken by such Third Party licensor. 
 6.6 Patent Extensions. Subject to the remainder of this Section 6.6, if any election for patent term restoration or extension, supplemental protection certificate or any of their

  
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AS AMENDED. 
  

 
equivalents may be made with respect to any Patent within the Licensed IP, after consultation with Celgene, the Parties will discuss and seek to reach mutual agreement whether or not to take such
action. If the Parties are not able to reach mutual agreement, (i) Celgene will have the sole right to make the final decision whether or not to seek such patent term restoration or extension, supplemental protection certificate or any of their
equivalents with respect to Specific Patents and Patents within the Collaboration IP licensed to Celgene hereunder and (ii) Bluebird will have the sole right to make the final decision whether or not to seek such patent term restoration or
extension, supplemental protection certificate or any of their equivalents with respect to all other Patents within the Licensed IP. 
 6.7 Regulatory Exclusivity Periods. With respect to any Patent listings required for any Regulatory Exclusivity Periods for Product, the Parties will mutually agree on which Patents within the
Licensed IP to list, provided that if the Parties are not able to agree, Celgene will have the right to make the final decision, and provided further that the exercise of such right by Celgene will not increase or otherwise change the rights or
obligations of the Parties hereunder. 
 6.8 Cooperation. Each Party will reasonably cooperate with the other Party in
the Prosecution and Maintenance of Patents within the Licensed IP. Such cooperation includes promptly executing all documents, or requiring inventors, subcontractors, employees and consultants and agents of Celgene and Bluebird and their respective
Affiliates and Sublicensees to execute all documents, as reasonable and appropriate so as to enable the Prosecution and Maintenance of any such Patents in any country. 
 6.9 Patent Marking. Celgene will mark, and will cause all other Selling Parties to mark, Product with all Patents within the Licensed IP in accordance with applicable Law, which marking obligation
will continue for as long as (and only for as long as) required under applicable Law. 
 6.10 Common Interest
Disclosures. With regard to any information or opinions disclosed pursuant to this License Agreement by one Party to the other Party regarding Prosecution and Maintenance of Patent within the Licensed IP, or enforcement of intellectual property
and/or technology by or against Third Parties, Bluebird and Celgene agree that they have a common legal interest in determining the ownership, scope, validity and/or enforcement of the Licensed IP, and whether, and to what extent, Third Party
intellectual property rights may affect the conduct of the Development and Commercialization of any Licensed Product, and have a further common legal interest in defending against any actual or prospective Third Party claims based on allegations of
misuse or infringement of intellectual property rights relating to the Development or Commercialization of any Licensed Product. Accordingly, the Parties agree that all such information and materials obtained by the Parties from each other will be
used solely for purposes of the Parties’ common legal interests with respect to the conduct of the Agreement. All such information and materials will be treated as protected by the attorney-client privilege, the work product privilege, and any
other privilege or immunity that may otherwise be applicable. By sharing any such information and materials, neither Party intends to waive or limit any privilege or immunity that may apply to the shared information and materials. Neither Party will
have the authority to waive any privilege or immunity on behalf of the other Party without such other Party’s prior written consent, nor will the waiver of privilege or immunity resulting from the conduct of one Party be deemed to apply against
any other Party. This 

  
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AS AMENDED. 
  

 
Section 6.10 will be subject to any right granted by either Party to any Third Party, provided that the grant of such right to such Third Party does not conflict with the other Party’s
rights or the first Party’s obligations under this License Agreement. 
  

	7.	Patent Enforcement and Defense. 

 7.1 Notice. Each Party will promptly notify, in writing, the other Party upon learning of any actual or suspected Competitive Infringement of any Patents within the Licensed IP by a Third Party, or
of any claim of invalidity, unenforceability, or non-infringement of any Patents within the Licensed IP, and will, along with such notice, supply the other Party with any evidence in its possession pertaining thereto. For purposes of this License
Agreement, “Competitive Infringement” means any allegedly infringing activity in the Field (which, for the purposes of this definition, will include all indications and will not be limited to cancer) with respect to a Patent within
the Licensed IP, which activity (i) falls within the scope then in effect of the licenses granted by Bluebird to Celgene as set forth in Sections 3.1, (ii) is subject to Section 7.2(f), or (iii) would be competitive with a
Licensed Product and targets the same Target Antigen as such Licensed Product. 
 7.2 Enforcement and Defense. [***]

 7.3 Third Party Rights. To the extent that a Third Party licensor of Bluebird has retained any right to
(i) defend against a declaratory judgment action or other action challenging any Patents within the Licensed IP, (ii) seek to abate any Competitive Infringement of the Patents within the Licensed IP by a Third Party, or (iii) take any
other actions described in Section 7.2 for any Patent within the Licensed IP licensed to Celgene hereunder (including pursuant to an Applicable Bluebird In-License), or otherwise be involved in such activities, Bluebird will use commercially
reasonable efforts to cause such Third Party licensor to take the actions specified by this Section 7.3 in a manner consistent with the in-license applicable thereto, but Bluebird will not be deemed to be in breach of its obligations under this
Section 7.3 if, after using such commercially reasonable efforts, it is unable to comply with such obligations because of actions taken or not taken by such Third Party licensor.  

 

	8.	Confidentiality. 

The Parties acknowledge and agree that terms of this License Agreement and all Materials, ideas and information of any kind, whether in
written, oral, graphical, machine-readable or other form, whether or not marked as confidential or proprietary, which are transferred, disclosed or made available by a Party or at the request of a Party, including any of the foregoing of Third
Parties, will be subject to the provisions of Section 10 of the Master Collaboration Agreement. The Parties agree to issue the joint press release on Appendix E promptly following the License Agreement Effective Date. A redacted version
of this License Agreement is attached hereto as Appendix I. 
  

	9.	Warranties; Limitations of Liability; Indemnification. 

 9.1 Representations and Warranties. Each Party represents and warrants to the other as of the License Agreement Effective Date that it has the legal right and power to enter into this License
Agreement, to extend the rights and licenses granted or to be granted to the other in this License Agreement, and to fully perform its obligations hereunder. 

  
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AS AMENDED. 
  

 9.2 Additional Representations and Warranties of Bluebird. Except as set forth in
Schedule 9.2, Bluebird represents and warrants to Celgene that, as of the License Agreement Effective Date: 
 (a)
Licensed IP. Appendix F sets forth a complete and accurate list of all Patents included in the Licensed IP, indicating the owner, licensor and/or co-owner(s), if applicable, and, for any Elected Candidate and Licensed Product-relevant
subject matter or Materials, if no Patent is specifically licensed, a list of all subject matter or Materials that are included in the Licensed IP, including those licensed under a materials use license or equivalent. Bluebird Controls the Patents
listed on Appendix F and the Know-How within the Licensed IP, and is entitled to grant the licenses specified herein. Bluebird has not granted to any Third Party any rights or licenses under such Patents or Know-How within the Licensed IP
that would conflict with the licenses granted to Celgene hereunder. 
 (b) Third Party Agreements. The Applicable
Bluebird In-Licenses are valid and binding obligations of Bluebird and, to the Knowledge of Bluebird, the applicable licensor, enforceable against Bluebird and, to the Knowledge of Bluebird, the applicable licensor, in accordance with their terms,
except as may be limited by general principles of equity (regardless of whether considered in a proceeding at law or in equity) and by applicable bankruptcy, insolvency, moratorium and other similar Laws of general application relating to or
affecting creditors’ rights generally. Neither Bluebird nor any of its Affiliates has received any notice of any counterparty’s intention to terminate any Applicable Bluebird In-License in whole or in part or any notice requesting any
amendment, alteration or modification of such Applicable Bluebird In-License or any sublicense or assignment thereunder. There is no breach or default, or event which upon notice or the passage of time, or both, could give rise to any breach or
default, in the performance of any Applicable Bluebird In-License by Bluebird or any of its Affiliates or, to the Knowledge of Bluebird, the counterparty thereto, and Bluebird has not received any notice of any such breach, default or event. Except
for the Applicable Bluebird In-Licenses, neither Bluebird nor any of its Affiliates is a party to any license, sublicense or other agreement pursuant to which Bluebird or such Affiliate has received a license or other rights relating to the Elected
Candidate or Licensed Product. All Patents and Know-How licensed to Bluebird under the Applicable Bluebird In-Licenses are Controlled by Bluebird for purposes of the licenses granted to Celgene under this License Agreement. 

(c) Patents. To Bluebird’s Knowledge, the Patents listed on Appendix F have been procured or are being procured from
the respective patent offices in accordance with applicable Law. None of the Patents included in the Licensed IP is or has been involved in any opposition, cancellation, interference, reissue or reexamination proceeding, and no Licensed IP is the
subject of any judicial, administrative or arbitral order, award, decree, injunction, lawsuit, proceeding or stipulation. Neither Bluebird nor any of its Affiliates has received any notice alleging that the Patents in the Licensed IP are invalid or
unenforceable, or challenging Bluebird’s ownership of or right to use any such rights. 
 (d) No Conflicts. The
execution, delivery and performance by Bluebird of this License Agreement and the consummation of the transactions contemplated hereby will not result in any violation of, conflict with, result in a breach of or constitute a default under any
understanding, contract or agreement to which Bluebird is a party or by which it is bound. 

  
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AS AMENDED. 
  

 
Neither Bluebird nor any of its Affiliates has entered into any agreement or otherwise licensed, granted, assigned, transferred, conveyed or otherwise encumbered or disposed of any right, title
or interest in or to any of its assets, including any intellectual property rights, that would in any way conflict with or impair the scope of any rights or licenses granted to Celgene hereunder. 

(e) Outlicenses. Appendix G sets forth a complete and accurate list of all agreements relating to the licensing,
sublicensing or other granting of rights by Bluebird to any Person with respect to the Licensed IP and the Field, and Bluebird has provided complete and accurate copies of all such agreements to Celgene. Except for the Applicable Bluebird
In-Licenses, Bluebird and its Affiliates are not subject to any payment obligations to Third Parties as a result of the execution or performance of this License Agreement. Neither Bluebird nor any of its Affiliates has granted any liens or security
interests on the Licensed IP and the Licensed IP is free and clear of any mortgage, pledge, claim, security interest, covenant, easement, encumbrance, lien or charge of any kind. 

(f) No Proceedings. There is no action, suit, proceeding or investigation pending or, to the Knowledge of Bluebird, currently
threatened in writing against or affecting Bluebird that questions the validity of this License Agreement or the right of Bluebird to enter into this License Agreement or consummate the transactions contemplated hereby. 

(g) No Infringement. Neither Bluebird nor any of its Affiliates has received any notice of any claim that any Patent, Know-How or
other intellectual property Controlled by a Third Party would be infringed or misappropriated by the production, use, research, Development, Manufacture or Commercialization of the Elected Candidate or Licensed Product pursuant to this License
Agreement, and, to the Knowledge of Bluebird, there are no Patents, Know-How or other intellectual property owned by a Third Party and not included in the Licensed IP or In-Licensed IP that are necessary for the production, use, research,
Development, Manufacture or Commercialization of Elected Candidate or Licensed Product. 
 9.3 Disclaimers. Without
limiting the respective rights and obligations of the Parties expressly set forth herein, each Party specifically disclaims any guarantee that any Licensed Product will be successful, in whole or in part. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN
THIS LICENSE AGREEMENT, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, WITH RESPECT TO ANY PATENTS, KNOW-HOW, ELECTED CANDIDATE OR LICENSED PRODUCT, INCLUDING WARRANTIES OF VALIDITY OR
ENFORCEABILITY OF ANY PATENT RIGHTS, TITLE, QUALITY, MERCHANTABILITY, FITNESS FOR A PARTICULAR USE OR PURPOSE, PERFORMANCE, AND NONINFRINGEMENT OF ANY THIRD PARTY PATENTS OR OTHER INTELLECTUAL PROPERTY RIGHTS. 

9.4 [***] 
 9.5
Performance by Others. The Parties recognize that each Party may perform some or all of its obligations under this License Agreement through Affiliates and permitted subcontractors provided, however, that each Party will remain responsible
and liable for the performance by its Affiliates and permitted subcontractors and will cause its Affiliates and permitted subcontractors to comply with the provisions of this License Agreement in connection therewith. 

  
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AS AMENDED. 
  

 9.6 Indemnification. 

(a) Indemnification by Celgene. Celgene will indemnify Bluebird, its Affiliates and their respective directors, officers,
employees, Third Party licensors and agents, and their respective successors, heirs and assigns (collectively, “Bluebird Indemnitees”), and defend and save each of them harmless, from and against any and all losses, damages,
liabilities, costs and expenses (including reasonable attorneys’ fees and expenses) (collectively, “Losses”) in connection with any and all suits, investigations, claims or demands of Third Parties (collectively, “Third
Party Claims”) against the Bluebird Indemnitees arising from or occurring as a result of: (i) the material breach by Celgene of any term of this License Agreement; (ii) any gross negligence or willful misconduct on the part of
Celgene in performing its obligations under this License Agreement; or (iii) the Development or Commercialization by or on behalf of Celgene or any of its Affiliates or Sublicensees of Elected Candidate or Licensed Product, except in each case
for those Losses for which Bluebird has an obligation to indemnify Celgene pursuant to Section 9.6(b), as to which Losses each Party will indemnify the other to the extent of their respective liability; provided, however, that Celgene will not
be obligated to indemnify Bluebird Indemnitees for any Losses to the extent that such Losses arise as a result of gross negligence or willful misconduct on the part of an Bluebird Indemnitee. 

(b) Indemnification by Bluebird. Bluebird will indemnify Celgene, its Affiliates and their respective directors, officers,
employees and agents, and their respective successors, heirs and assigns (collectively, “Celgene Indemnitees”), and defend and save each of them harmless, from and against any and all Losses in connection with any and all Third
Party Claims against Celgene Indemnitees arising from or occurring as a result of: (i) the material breach by Bluebird of any term of this License Agreement; (ii) any gross negligence or willful misconduct on the part of Bluebird in
performing its obligations under this License Agreement; or (iii) the Development by or on behalf of Bluebird or any of its Affiliates or Sublicensees of Elected Candidate or Licensed Product, except in each case for those Losses for which
Celgene has an obligation to indemnify Bluebird pursuant to Section 9.6(a), as to which Losses each Party will indemnify the other to the extent of their respective liability for the Losses; provided, however, that Bluebird will not be
obligated to indemnify Celgene Indemnitees for any Losses to the extent that such Losses arise as a result of gross negligence or willful misconduct on the part of a Celgene Indemnitee. 

(c) Notice of Claim. All indemnification claims provided for in Sections 9.6(a) and 9.6(b) will be made solely by such Party to
this License Agreement (the “Indemnified Party”). The Indemnified Party will promptly notify the indemnifying Party (an “Indemnification Claim Notice”) of any Losses or the discovery of any fact upon which the
Indemnified Party intends to base a request for indemnification under Section 9.6(a) and 9.6(b), but in no event will the indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification
Claim Notice must contain a description of the claim and the nature and estimated amount of such Loss (to the extent that the nature and amount of such Loss is known at such time). The Indemnified Party will furnish promptly to the indemnifying
Party copies of all papers and official documents received in respect of any Losses and Third Party Claims. 

  
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AS AMENDED. 
  

 (d) Defense, Settlement, Cooperation and Expenses. 

(i) Control of Defense. At its option, the indemnifying Party may assume the defense of any Third Party Claim by giving written
notice to the Indemnified Party within thirty (30) days after the indemnifying Party’s receipt of an Indemnification Claim Notice, provided however that (i) the Third Party Claim solely seeks monetary damages and (ii) the
indemnifying Party expressly agrees in writing that as between the indemnifying Party and the Indemnified Party, the indemnifying Party will be solely obligated to satisfy and discharge the Third Party Claim in full and is able to reasonably
demonstrate that it has sufficient financial resources (the matters described in (i) and (ii), the “Litigation Conditions”). The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed
as an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor will it constitute a waiver by the indemnifying Party of any defenses it may assert against the Indemnified
Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party (the
indemnifying Party will consult with the Indemnified Party with respect to a possible conflict of interest of such counsel retained by the indemnifying Party). In the event the indemnifying Party assumes the defense of a Third Party Claim, the
Indemnified Party will immediately deliver to the indemnifying Party all original notices and documents (including court papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the
defense of a Third Party Claim, except as provided in Section 9.6(d)(ii), the indemnifying Party will not be liable to the Indemnified Party for any legal costs or expenses subsequently incurred by such Indemnified Party in connection with the
analysis, defense or settlement of the Third Party Claim. The Indemnified Party may, at any time, assume the defense of a Third Party Claim if at any time the Litigation Conditions are not satisfied with respect to such Claim. In the event that it
is ultimately determined that the indemnifying Party is not obligated to indemnify, defend or hold harmless the Indemnified Party from and against the Third Party Claim, the Indemnified Party will reimburse the indemnifying Party for any and all
costs and expenses (including attorneys’ fees and costs of suit) and any Third Party Claims incurred by the indemnifying Party in its defense of the Third Party Claim. 
 (ii) Right to Participate in Defense. Without limiting Section 9.6(d)(i), any Indemnified Party will be entitled to participate in, but not control, the defense of such Third Party Claim and
to employ counsel of its choice for such purpose; provided, however, that such employment will be at the Indemnified Party’s own cost and expense unless (i) the employment thereof has been specifically authorized by the indemnifying Party
in writing, (ii) the indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 9.6(d)(i) (in which case the Indemnified Party will control the defense), (iii) the interests of the Indemnified
Party and the indemnifying Party with respect to such Third Party Claim are sufficiently adverse to prohibit the representation by the same counsel of both Parties under applicable Law, ethical rules or equitable principles, or (iv) the
indemnifying Party no longer satisfies the Litigation Conditions, in which case the indemnifying Party will assume [***]percent ([***]%) of any such costs and expenses of counsel for the Indemnified Party. 

  
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AS AMENDED. 
  

 (iii) Settlement. With respect to any Third Party Claims that relate solely to
the payment of money damages in connection with a Third Party Claim and that will not result in the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified Party in any
manner, and as to which the indemnifying Party will have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, and subject to the Litigation Conditions being satisfied, the indemnifying Party will have the sole right
to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, will deem appropriate. With respect to all other Losses in connection with Third
Party Claims, where the indemnifying Party has assumed the defense of the Third Party Claim in accordance with Section 9.6(d)(i), the indemnifying Party will have authority to agree to the entry of any judgment, enter into any settlement or
otherwise dispose of such Loss provided it obtains the prior written consent of the Indemnified Party (such consent not to be unreasonably withheld, delayed or conditioned). The indemnifying Party will not be liable for any settlement or other
disposition of a Loss by an Indemnified Party that is reached without the prior written consent of the indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party will
admit any liability with respect to or settle, compromise or discharge, any Third Party Claim without the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld, delayed or conditioned. 

(iv) Cooperation. If the indemnifying Party chooses to defend or prosecute any Third Party Claim, the Indemnified Party will, and
will cause each other Indemnified Party to, cooperate in the defense or prosecution thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and
appeals as may be reasonably requested in connection therewith. Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that
are reasonably relevant to such Third Party Claim, and making Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the
indemnifying Party will reimburse the Indemnified Party for all its reasonable out-of-pocket costs and expenses in connection therewith. 
 (v) Costs and Expenses. Except as provided above in this Section 9.6(d), the costs and expenses, including attorneys’ fees and expenses, incurred by the Indemnified Party in connection
with any claim will be reimbursed on a calendar quarter basis by the indemnifying Party, without prejudice to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the
indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 
 9.7 Insurance. Each
Party will maintain at its sole cost and expense, an adequate liability insurance or self-insurance program (including product liability insurance) to protect against potential liabilities and risk arising out of activities to be performed under
this License Agreement, and any agreement related hereto and upon such terms (including coverages, deductible limits and self-insured retentions) as are customary in the U.S. pharmaceutical industry for the activities to be conducted by such Party
under this License Agreement. Subject to the preceding sentence, such liability insurance or self-insurance program will insure against 

  
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AS AMENDED. 
  

 
all types of liability, including personal injury, physical injury or property damage arising out of the manufacture, sale, use, distribution or marketing of Licensed Product. The coverage limits
set forth herein will not create any limitation on a Party’s liability to the other under this License Agreement. 
  

	10.	Term and Termination. 

 10.1 Term. This License Agreement will commence as of the License Agreement Effective Date and, unless sooner terminated in accordance with the terms hereof or by mutual written consent, will
continue on a country-by-country basis, until there are no more payments owed Bluebird on Licensed Product in such country (the longest such period of time for any Licensed Product hereunder, the “License Agreement Term”). Upon
there being no more such payments hereunder for any such Licensed Product in such country, the licenses contained in Section 3.1 for such Licensed Product will become fully paid up and will remain exclusive with respect to such Licensed Product
in such country. 
 10.2 Termination by Bluebird. 

(a) Breach. Bluebird will have the right to terminate this License Agreement in full upon delivery of written notice to Celgene in
the event of any material breach by Celgene of any terms and conditions of this License Agreement in a manner that fundamentally frustrates the transactions contemplated by this License Agreement, provided that such termination will not be effective
if such breach, has been cured within [***] after written notice thereof is given by Bluebird to Celgene specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] after such notice if Celgene commences
actions to cure such default within such [***] and thereafter diligently continues such actions, but fails to cure the default by the end of such [***]); provided, however, that to the extent such material breach involves the failure to make a
payment when due, such breach must be cured within [***] after written notice thereof is given by Bluebird to Celgene. 
 (b)
[***] 
 10.3 Termination by Celgene. 
 (a) Breach. Celgene will have the right to terminate this License Agreement in full upon delivery of written notice to Bluebird in the event of any material breach by Bluebird of any terms and
conditions of this License Agreement in a manner that fundamentally frustrates the transactions contemplated by this License Agreement, provided that such termination will not be effective if such breach has been cured within [***] after written
notice thereof is given by Celgene to Bluebird specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] period, within [***] days after such notice if Bluebird commences actions to cure such default within
such [***] period and thereafter diligently continues such actions, but fails to cure the default by the end of such [***]). 

(b) Discretionary Termination. Beginning with [***], Celgene will have the right to terminate this License Agreement in full at
its discretion for any reason by delivering written notice to Bluebird, such termination to be effective [***] following the date of such notice. 
 (c) Alternative to Termination Under Section 10.3(a). If Celgene has the right to terminate this License Agreement under Section 10.3(a) (including expiration of all applicable

  
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AS AMENDED. 
  

 
cure periods thereunder), in lieu of exercising such termination right, Celgene may elect once by written notice to Bluebird before the end of such applicable cure period to have this License
Agreement continue in full force and effect and instead have, starting immediately after the end of such applicable cure period, any future Milestone Payments set forth in Section 4.2 and the royalty rates set forth in the table set forth in
Section 4.3(a) be reduced by [***], provided that such reduction will not apply if such future Milestone Payments and royalty rates have already been reduced pursuant to Section 11.4(c) of the Master Collaboration Agreement. 

10.4 Effects of Termination. Upon termination (but not expiration pursuant to Section 10.1) of this License Agreement for any
reason: 
 (a) Wind Down. Celgene will responsibly wind-down, in accordance with accepted pharmaceutical industry norms
and ethical practices, any on-going clinical studies for which it has responsibility hereunder in which patient dosing has commenced or, if reasonably practicable and requested by Bluebird, allow Celgene, its Affiliates or its Sublicensees to
complete such trials. Celgene will be responsible for any costs associated with such wind-down. Bluebird will pay all costs incurred by either Party to complete such studies should Bluebird request that such studies be completed. 

(b) Sublicenses. A termination of this License Agreement will not automatically terminate any sublicense granted by Celgene
pursuant to Section 3.3 for Commercialization rights with respect to a non-Affiliated Sublicensee, provided that (i) such Sublicensee is not then (a) in material breach of any provision of this License Agreement or (b) in
material breach of the applicable sublicense agreement or otherwise in breach of such sublicense agreement in a manner that would give rise to a right of termination on the part of Celgene, (ii) if Bluebird terminates this License Agreement
pursuant to Section 10.2(a)(iii) for Celgene’s failure to fulfill its payment obligations hereunder, such Sublicensee agrees to and does pay to Bluebird all outstanding amounts that accrued as a result of such Sublicensee’s activities
under the sublicense, (iii) Bluebird will have the right to step into the role of Celgene as sublicensor under any such sublicense executed after the License Agreement Effective Date, with all the rights that Celgene had under such sublicense,
solely with respect to the Licensed IP, prior to termination of this License Agreement (including the right to receive any payments to Celgene by such Sublicensee that accrue from and after the date of the termination of this License Agreement
solely with respect to the Licensed IP), (iv) such Sublicensee will pay to Bluebird all amounts that Celgene would have been obligated to pay to Bluebird hereunder with respect to such Sublicensee’s activities had this License Agreement
not terminated (less any amounts received by Bluebird in clause (iii) above) and (v) the survival of such sublicense will not result in an imposition of any additional obligations on the part of Bluebird that are not included within the
scope of this License Agreement. Celgene will include in any sublicense agreement executed after the License Agreement Effective Date that relates solely to the Licensed IP a provision in which said Sublicensee acknowledges its obligations to
Bluebird under this Section 10.4(b). 
 (c) Cessation of Rights. Except as otherwise expressly provided in Sections
10.4(b), all rights and licenses granted by Bluebird to Celgene in Section 3.1 will terminate, and Celgene and its Affiliates and Sublicensees will cease all use of Licensed IP and all Development, Manufacture and Commercialization of Elected
Candidate and Licensed Product. 

  
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AS AMENDED. 
  

 (d) Regulatory Approvals. To the extent permitted by applicable Law, and subject
to Bluebird paying commercially reasonable compensation to Celgene for the assets to be transferred pursuant to this Section 10.4(d) (such compensation to either be mutually agreed to or determined through arbitration as provided in
Section 10.4(g) below, and such compensation to be reduced by [***] from what would be commercially reasonable compensation if this License Agreement is terminated by Bluebird pursuant to Section 10.2(a)), all Regulatory Approvals and
other regulatory filings and communications owned (in whole or in part) or otherwise Controlled by Celgene and its Affiliates and Sublicensees solely relating to the Elected Candidate and/or Licensed Product, and all other documents solely relating
to and necessary to further Develop and Commercialize Elected Candidate and Licensed Product, as such items exist as of the effective date of such termination (including all solely related completed and ongoing clinical studies) will be assigned to
Bluebird, and Celgene will provide to Bluebird one (1) copy of the foregoing and all documents contained in or referenced in any such items, together with the raw and summarized data for any clinical studies (and where reasonably available,
electronic copies thereof). In the event of failure to obtain assignment, subject to the Parties agreeing on commercially reasonable compensation for the right to access and reference, Celgene hereby consents and grants to Bluebird the right to
access and reference (without any further action required on the part of Celgene, whose authorization to file this consent with any Regulatory Authority is hereby granted) any such item. 

(e) Licenses. Subject to Bluebird paying (i) commercially reasonable compensation to Celgene for the licenses to be granted
pursuant to subsection (1) of this Section 10.4(e) (such compensation to either be mutually agreed to or determined through arbitration as provided in Section 10.4(g) below, and such compensation to be reduced by [***] from what would
be commercially reasonable compensation if this License Agreement is terminated by Bluebird pursuant to Section 10.2(a)), and (ii) amounts payable to Celgene’s applicable licensors as set forth below, Celgene will grant to Bluebird
and its Affiliates (1) a worldwide, perpetual and irrevocable, nontransferable (except in connection with a permitted assignment of this License Agreement in accordance with Section 11.12), exclusive license, with the right to grant
sublicenses through multiple tiers (subject to Section 3.3(b), mutatis mutandis), under the Celgene Licensed Product IP, and (2) an exclusive sublicense under the Celgene Licensed Product In-Licensed IP, in each case ((1) and
(2)) to the extent such Celgene Licensed Product IP and Celgene Licensed Product In-Licensed IP are used in or Cover the Licensed Product as of the effective date of termination and to the extent such Celgene Licensed Product IP and Celgene
Licensed Product In-Licensed IP exist as of the effective date of such termination (including in each case any additions, divisions, continuations, continuations-in-part, invention certificates, substitutions, reissues, reexaminations, extensions,
registrations, supplementary protection certificates and renewals of such Celgene Licensed Product IP and Celgene Licensed Product In-Licensed IP) solely to the extent necessary to research, Develop, Manufacture and Commercialize the Elected
Candidate and Licensed Product. With respect to grants of a sublicense under subsection (2) above, Bluebird will be responsible for all amounts payable to the applicable licensor, excluding maintenance fee payments, payments that are trigged by
the grant of a sublicense (but including payments triggered by further grants of sublicenses by Bluebird or its sublicensees) and Patent Costs, that are attributable to Bluebird as a sublicensee thereunder under this License Agreement and Celgene
will pay same and Bluebird will 

  
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AS AMENDED. 
  

 
reimburse Celgene for [***] of such payments within thirty (30) days of receipt of Celgene’s written invoice therefor. Celgene will provide Bluebird with copies of all applicable
Celgene Licensed Product In-Licenses promptly following the effective date of the termination of this License Agreement. The Prosecution and Maintenance and enforcement and defense rights and obligations of the Parties with respect to any Patents
licensed or sublicensed to Bluebird pursuant to this Section 10.4(e) will be discussed and agreed to by the Parties, with the understanding that such Prosecution and Maintenance and enforcement and defense rights and obligations will be
substantially similar to those set forth in Sections 6, with the roles of Bluebird and Celgene reversed (and such other changes as are appropriate from the context, and taking into account any rights retained by a Third Party licensor of Celgene to
Prosecute and Maintain or enforce and defend any Patent sublicensed to Bluebird under this Section 10.4(e)). Bluebird will abide, and will cause all its Affiliates and applicable sublicensees to abide, by all requirements of each Celgene
Licensed Product In-License under which Bluebird is sublicensed under this Section 10.4(e) in all material respects (and in any case in all respects in the case that failure to so abide would result in a breach under the Celgene Licensed
Product In-License), to the extent applicable to sublicensees thereunder and to the extent disclosed by Celgene to Bluebird, with the understanding that disclosure by Celgene of any Celgene Licensed Product In-License to Bluebird will be deemed
disclosure of such requirements of such Celgene Licensed Product In-License to Bluebird. 
 (f) Trademarks. Subject to
Bluebird paying commercially reasonable compensation to Celgene for the license to be granted pursuant to this Section 10.4(f) (such compensation to either be mutually agreed to or determined through arbitration as provided in
Section 10.4(g) below, and such compensation to be reduced by [***] from what would be commercially reasonable compensation if this License Agreement is terminated by Bluebird pursuant to Section 10.2(a)), Celgene will exclusively license
to Bluebird any registered or unregistered trademarks or internet domain names that are specific to and solely used for the Licensed Product worldwide (it being understood that the foregoing will not include any trademarks or internet domain names
that contain the corporate or business name(s) of Celgene). 
 (g) Baylor Product License. If the Licensed Product is
subject to a Baylor Product License, then Celgene will, at Bluebird’s written request, assign to Bluebird the applicable Baylor Product License in accordance with the terms of Section 13.5 thereof, provided that if such Baylor Product
License applies to other products, Celgene will assign or sublicense to Bluebird that portion of the Baylor Product License that applies to the Licensed Product, and with the consequences therein stated (that is, Celgene will remain responsible for
all payments accruing thereunder before the assignment, and Bluebird will be responsible for all payments accruing thereunder after such assignment). 
 (h) Commercially Reasonable Compensation. If the Parties are unable to agree on the amount of commercially reasonable compensation payable by Bluebird to Celgene pursuant to Sections 10.4(d),
10.4(e) or 10.4(f) within ten (10) days of the effective date of termination of this License Agreement, [***] 
 (i)
Country Termination. If this License Agreement is terminated only with respect to a specific country pursuant to Section 10.2(b), the provisions of this Section 10.4 will apply only with respect to such terminated country.

  
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AS AMENDED. 
  

 10.5 Survival. In addition to the termination consequences set forth in
Section 10.4, the following provisions will survive termination or expiration of this License Agreement: Sections 1, 3.3 (mutatis mutandis with respect to licenses granted to Bluebird under Section 10.4), 3.7, 3.8, 4.4, 5, 8, 9.3, 9.4,
9.6, 9.7, 10.4, and 11. Termination or expiration of this License Agreement will not relieve the Parties of any liability or obligation which accrued hereunder prior to the effective date of such termination or expiration nor preclude either Party
from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this License Agreement nor prejudice either Party’s right to obtain performance of any obligation. All other rights and obligations
will terminate upon expiration of this License Agreement. 
 10.6 Right to Set-off. Notwithstanding anything to the
contrary in this License Agreement, each Party has the right at all times to retain and set off against all amounts due and owing to the other Party as determined in a final judgment any damages recovered by such Party for any Losses incurred by
such Party. 
  

	11.	General Provisions. 

11.1 Cumulative Remedies and Irreparable Harm. All rights and remedies of the Parties hereunder will be cumulative and in addition
to all other rights and remedies provided hereunder or available by agreement, at law or otherwise. Each Party acknowledges and agrees that breach of any of the terms or conditions of this License Agreement would cause irreparable harm and damage to
the other and that such damage may not be ascertainable in money damages and that as a result thereof the non-breaching Party would be entitled to seek from a court equitable or injunctive relief restraining any breach or future violation of the
terms contained herein by the breaching Party without the necessity of proving actual damages or posting bond. Such right to equitable relief is in addition to whatever remedies either Party may be entitled to as a matter of law or equity, including
money damages. 
 11.2 Business Combination and IP. 

(a) Bluebird Business Combination. Notwithstanding anything to the contrary herein, for purposes of this License Agreement, no
Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Bluebird or any of its Affiliates prior to a Business Combination of Bluebird will be Controlled for purposes of this License Agreement after
such Business Combination of Bluebird, other than (i) Applicable Bluebird In-Licenses to the extent in effect immediately prior to such Business Combination of Bluebird, (ii) Collaboration IP, and (iii) any Patent that claims
priority, directly or indirectly, to any other Patent first Controlled before such Business Combination of Bluebird will be Controlled thereafter no matter when such Patent is filed or issued. 

(b) Celgene Business Combination. Notwithstanding anything to the contrary herein, for purposes of this License Agreement, no
Know-How, Materials, Patents Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Celgene or any of its Affiliates prior to a Business Combination of Celgene will be Controlled for purposes of this License Agreement after
such Business Combination of Celgene, other than Collaboration IP, and except that any Patent that claims priority, directly or indirectly, to any other Patent first Controlled before such Business Combination of Celgene will be Controlled
thereafter no matter when such Patent is filed or issued. 

  
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AS AMENDED. 
  

 11.3 Relationship of Parties. Nothing in this License Agreement is intended or
will be deemed to constitute a partnership, agency, employer-employee or joint venture relationship between the Parties. No Party will incur any debts or make any commitments for the other, except to the extent, if at all, specifically provided
therein. There are no express or implied third party beneficiaries hereunder (except for Bluebird Indemnitees and Celgene Indemnitees for purposes of Section 9.6). 
 11.4 Compliance with Law. Each Party will perform or cause to be performed any and all of its obligations or the exercise of any and all of its rights hereunder in good scientific manner and in
compliance with all applicable Law. Without limiting the foregoing, Bluebird will comply with comply with all applicable Laws and regulations (including U.S. Foreign Corrupt Practices Act and any other applicable anti-bribery or anti-kickback laws
or regulations). 
 11.5 Force Majeure. Neither Party will be liable to the other for failure of or delay in performing
obligations set forth in this License Agreement (other than any obligation to pay monies when due), and neither will be deemed in breach of such obligations, if such failure or delay is due to natural disasters or any causes reasonably beyond the
control of such Party; provided that the Party affected will promptly notify the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any such causes and to resume performance of its obligations as
soon as possible. 
 11.6 Governing Law. This License Agreement will be governed by and construed in accordance with the
Laws of the State of New York, without respect to its conflict of laws rules, provided that any dispute relating to the scope, validity, enforceability or infringement of any Patents or Know-How will be governed by, and construed and enforced in
accordance with, the substantive Laws of the jurisdiction in which such Patents or Know-How apply. 
 11.7 Counterparts;
Facsimiles. This License Agreement may be executed in one or more counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the same instrument. Facsimile or PDF execution and delivery of this
License Agreement by either Party will constitute a legal, valid and binding execution and delivery of this License Agreement by such Party 
 11.8 Headings. All headings in this License Agreement are for convenience only and will not affect the meaning of any provision hereof. 

11.9 Waiver of Rule of Construction. Each Party has had the opportunity to consult with counsel in connection with the review,
drafting and negotiation of this License Agreement. Accordingly, the rule of construction that any ambiguity in this License Agreement will be construed against the drafting party will not apply. 

11.10 Interpretation. Whenever any provision of this License Agreement uses the term “including” (or
“includes”), such term will be deemed to mean “including without limitation” (or “includes without limitations”). “Herein,” “hereby,” “hereunder,” “hereof” and other equivalent
words refer to this License Agreement as an entirety and not solely to the particular portion of this License Agreement in which any such word is used. All definitions set forth herein will be deemed applicable whether the words defined are used
herein in the singular or the plural. 

  
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AS AMENDED. 
  

 
Unless otherwise provided, all references to Sections and Appendices in this License Agreement are to Sections and Appendices of this License Agreement. References to any Sections include
Sections and subsections that are part of the related Section (e.g., a section numbered “Section 2.1” would be part of “Section 2”, and references to “Section 2.1” would also refer to material contained in the
subsection described as “Section 2.1(a)”). 
 11.11 Binding Effect. This License Agreement will inure to the
benefit of and be binding upon the Parties, their Affiliates, and their respective lawful successors and assigns. 
 11.12 Assignment. This License Agreement may not be assigned by either Party, nor may either Party delegate its obligations or otherwise transfer licenses or other rights created by this License
Agreement, except as expressly permitted hereunder or otherwise without the prior written consent of the other Party, which consent will not be unreasonably withheld, delayed or conditioned; provided that without consent (i) Celgene may assign
this License Agreement to (x) an Affiliate or (y) its successor in connection with the merger, consolidation, or sale of all or substantially all of its assets, and (ii) Bluebird may assign this License Agreement to (x) an
Affiliate or (y) its successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business pertaining to the subject matter of this License Agreement; provided further that,
except in the case where a Party is involved in a merger or consolidation where it is the surviving entity and no assets of such Party that are subject to this License Agreement have been transferred as a result of such merger or consolidation,
(a) such assigning Party provides the other Party to this Agreement with at least thirty (30) business days advance written notice of such assignment(s) and the assigning Party agrees in a written agreement delivered prior to such
assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to remain fully liable for the performance of its obligations under this Agreement by its assignee(s), (b) the assignee(s) agree in a written agreement
delivered prior to such assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to assume performance of all such assigned obligations, (c) in the case of any assignment by Bluebird, all Licensed IP licensed
to Celgene under this License Agreement will be transferred to such assignee(s) effective as of such assignment(s), (d) all of the matters referred to in clauses (a), (b) and (c), as applicable, will be set forth in documentation
reasonably acceptable to the non-assigning Party prior to any such assignment(s) (and with such reasonable acceptance not to be unreasonably withheld, conditioned or delayed) and in all cases will provide the non-assigning Party with the full
benefits of its rights under this Agreement (after taking into account all risks involving applicable counter-party performance and bankruptcy and insolvency risks, including those involving contractual rejection under 11 USC §365) as if no
such assignment(s) had occurred, and (e) in the case of any assignment, the assigning Party will reimburse the non-assigning Party for all of the legal fees and expenses incurred by such non-assigning Party in connection with the matters set
forth in clause (d) of this sentence in an aggregate amount not to exceed [***], and provided, further, that if Bluebird wishes to assign any Licensed IP to its Affiliates, it will be permitted to do so conditioned on each such Affiliate
becoming a party to this License Agreement, in the form of an amendment to this License Agreement executed by Celgene, Bluebird and such Affiliate, pursuant to which such Affiliate would agree to assume all obligations hereunder, and grant to
Celgene all rights hereunder, with respect to the Licensed IP. The terms of this Agreement will be binding upon and will inure to the benefit of the successors, heirs, administrators and permitted assigns of the Parties. Any purported assignment in
violation of this Section 11.12 will be null and void ab initio. 

  
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AS AMENDED. 
  

 11.13 Notices. All notices, requests, demands and other communications required
or permitted to be given pursuant to this License Agreement will be in writing and will be deemed to have been duly given upon the date of receipt if delivered by hand, recognized international overnight courier, confirmed facsimile transmission, or
registered or certified mail, return receipt requested, postage prepaid to the applicable address or facsimile number set forth in Section 13.14 of the Master Collaboration Agreement. Either Party may change its designated address and facsimile
number by notice to the other Party in the manner provided in this Section 11.13 
 11.14 Amendment and Waiver. This
License Agreement may be amended, supplemented, or otherwise modified only by means of a written instrument signed by both Parties; provided that any unilateral undertaking or waiver made by one Party in favor of the other will be enforceable if
undertaken in a writing signed by the Party to be charged with the undertaking or waiver. Any waiver of any rights or failure to act in a specific instance will relate only to such instance and will not be construed as an agreement to waive any
rights or fail to act in any other instance, whether or not similar. 
 11.15 Severability. In the event that any
provision of this License Agreement will, for any reason, be held to be invalid or unenforceable in any respect, such invalidity or unenforceability will not affect any other provision hereof, and the Parties will negotiate in good faith to modify
this License Agreement to preserve (to the extent possible) their original intent. 
 11.16 Entire Agreement. This
License Agreement, together with the Master Collaboration Agreement, is the sole agreement with respect to the subject matter and supersedes all other agreements and understandings between the Parties with respect to same (including Confidential
Agreement). In the event of any conflict between the terms of this License Agreement and the terms of the Master Collaboration Agreement, the terms of this License Agreement will control. 

11.17 Force Majeure. Neither Celgene nor Bluebird will be liable for failure of or delay in performing obligations set forth in
this License Agreement (other than any obligation to pay monies when due), and neither will be deemed in breach of such obligations, if such failure or delay is due to natural disasters or any causes reasonably beyond the control of Celgene or
Bluebird and without the fault or negligence of the Party so failing or delaying; provided that the Party affected will promptly notify the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any
such causes and to resume performance of its obligations as soon as possible. 
 [Remainder of this Page Intentionally Left
Blank] 

  
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AS AMENDED. 
  

 IN WITNESS WHEREOF, the Parties have caused this License Agreement to be executed by
their respective duly authorized officers as of the License Agreement Effective Date. 
  

			
	BLUEBIRD BIO, INC.
		
	By:	 	  

		 	(Signature)
		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

	
	CELGENE CORPORATION
		
	By:	 	  

		 	(Signature)
		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

  
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AS AMENDED. 
  

 Appendix A 

Additional Defined Terms 
 “Elected Candidate”20 means the
Optioned Candidate selected by Celgene under the Master Collaboration Agreement that specifically targets the following Target Antigen:
[                    ]. 
  

 

	20 	 To be updated by the Parties to specifically identify the candidate that is the subject of the option election.

  

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AS AMENDED. 
  

 Appendix B 

Applicable New In-Licenses 

  

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AS AMENDED. 
  

 Appendix C 

Applicable Pre-Existing In-Licenses 

  

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AS AMENDED. 
  

 Appendix D 

Certain Manufacturing Definitions 
 [***] 

  

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AS AMENDED. 
  

 Appendix E 

Press Release 

  

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AS AMENDED. 
  

 Appendix F 

Certain Patents within the Licensed IP Controlled 
 by Bluebird as of the License Agreement Effective Date 

  

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AS AMENDED. 
  

 Appendix G 

Bluebird Agreements 

  

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AS AMENDED. 
  

 [***] 

  

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AS AMENDED. 
  

 Appendix I 

Redacted Version of License Agreement 

  

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AS AMENDED. 
  

 Schedule 9.2 

Exceptions to Bluebird’s Representations and Warranties in Section 9.2 

  

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AS AMENDED. 
  

 Exhibit B 
 Co-Development, Co-Promote and Profit Share Agreement 

  

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AS AMENDED. 
  

 Co-Development, Co-Promote and Profit Share Agreement 

by and between 
 bluebird bio, Inc. 
 and 

Celgene Corporation 
 [                    ] 

  

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AS AMENDED. 
  

 Table of Contents 

 

							
	 	 	 	  	Page	 
			
	 1.
	 	Definitions	  	 	1	  
			
	 2.
	 	Overview	  	 	7	  
			
	 3.
	 	Governance and Joint Governance Committee	  	 	8	  
			
	 4.
	 	Development	  	 	10	  
			
	 5.
	 	Commercialization	  	 	12	  
			
	 6.
	 	Regulatory	  	 	15	  
			
	 7.
	 	Manufacture and Supply	  	 	16	  
			
	 8.
	 	Supporting Provisions for Development and Commercialization	  	 	17	  
			
	 9.
	 	In-Licenses	  	 	19	  
			
	 10.
	 	License Grants	  	 	21	  
			
	 11.
	 	Payments and Royalties	  	 	25	  
			
	 12.
	 	Ownership and Inventorship of IP	  	 	29	  
			
	 13.
	 	Patent Prosecution and Maintenance	  	 	30	  
			
	 14.
	 	Patent Enforcement and Defense	  	 	33	  
			
	 15.
	 	Confidentiality	  	 	33	  
			
	 16.
	 	Warranties; Limitations of Liability; Indemnification	  	 	33	  
			
	 17.
	 	Term and Termination	  	 	39	  
			
	 18.
	 	General Provisions	  	 	44	  

  

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AS AMENDED. 
  

 List of Appendices 

 

			
		
	 Appendix A
	 	Additional Definitions
		
	 Appendix B
	 	Applicable New In-Licenses
		
	 Appendix C
	 	Applicable Pre-Existing In-Licenses
		
	 Appendix D
	 	Certain Manufacturing Definitions
		
	 Appendix E
	 	Co-Co In-Licenses
		
	 Appendix F
	 	Profit & Loss Share
		
	 Appendix G
	 	Press Release
		
	 Appendix H
	 	Certain Patents Within the Licensed IP as of the CCPS Agreement Effective Date
		
	 [***]
	 	
		
	 Appendix J
	 	Bluebird Agreements

  

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AS AMENDED. 
  

 Co-Development, Co-Promote and Profit Share Agreement 

This Co-Development, Co-Promote and Profit Share Agreement (this “CCPS Agreement”), dated as of
[                    ] (the “CCPS Agreement Effective Date”), is made by and between bluebird bio, Inc., a Delaware corporation
(“Bluebird”), and Celgene Corporation, a Delaware (“Celgene”). Each of Bluebird and Celgene may be referred to herein as a “Party” or together as the “Parties.” 

WHEREAS, Bluebird has developed and owns or has rights to certain Patents and technology relating to developing innovative gene therapies
for genetic disorders; 
 WHEREAS, Celgene is a biopharmaceutical company focused on acquiring, Developing and Commercializing
innovative anti-cancer agents; and 
 WHEREAS, Bluebird and Celgene are parties to that certain Master Collaboration Agreement
(dated [            ], 2013) (the “Master Collaboration Agreement”) pursuant to which Celgene has an option to take a license to Product Candidates; 

WHEREAS, pursuant to the terms of the Master Collaboration Agreement, Celgene has exercised its option to select a Product Candidate to
be an Optioned Candidate by delivering to Bluebird a Celgene Option Notice and payment of the applicable Initial Option Fee (such Optioned Candidate, as defined more fully in Appendix A, the “Elected Candidate”);

 WHEREAS, pursuant to Section 5.3 of the Master Collaboration Agreement, Bluebird has delivered a Bluebird Option Notice
to co-promote and co-Develop the Optioned Candidate in the U.S.; and 
 WHEREAS, the Parties now wish to enter into an exclusive
arrangement whereby Bluebird and Celgene will co-Develop Licensed Product and Commercialize Licensed Product in the U.S. as part of a profit share arrangement, and Celgene will have exclusive rights to Commercialize Licensed Product in the ROW, all
on the terms and conditions set forth here. 
 NOW, THEREFORE, in consideration of the mutual covenants contained herein, and
for other good and valuable consideration, the amount and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 
  

	1.	Definitions.  

 The following terms
and their correlatives will have the meanings set forth below. Capitalized terms used, but not defined, herein will have the meanings ascribed to such terms in the Master Collaboration Agreement. 

1.1 “Applicable Bluebird In-Licenses” means the Applicable Pre-Existing In-Licenses, the Applicable New In-Licenses, and
any Co-Co In-Licenses where Bluebird is a contracting party. 
 1.2 “Applicable New In-Licenses” means all New
In-Licenses of Bluebird or its Affiliates necessary or useful for the research, Development and/or Commercialization of Elected Candidate and Licensed Product that Celgene has elected to list on Appendix B as of the CCPS Agreement Effective
Date, plus any other New In-License of Bluebird or its Affiliates that Celgene has elected to include as an Applicable New In-License pursuant to Section 10.7(b). 

  
 1 

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AS AMENDED. 
  

 1.3 “Applicable Pre-Existing In-Licenses” means all Pre-Existing
In-Licenses necessary or useful for the research, Development and/or Commercialization of Elected Candidate and Licensed Product, and any extensions or expansions of the scope of such Pre-Existing In-Licenses, including those listed
on Appendix C. 
 1.4 “Biosimilar Product” means, with respect to a Licensed Product in any
country, any biosimilar product sold by a Third Party not authorized by or on behalf of Celgene, its Affiliates or Sublicensees, (i) that is a biosimilar biological product, as defined in 21 USC 379j-51 (or any successor or replacement
thereof), a similar biological medicinal product, as defined in Annex I to Directive 2001/83/EC (or any successor or replacement thereof), or any similar biosimilar or generic product under the Laws of any country or jurisdiction, or
(ii) regarding which Regulatory Approval is obtained by referencing Regulatory Data of such Licensed Product. 
 1.5
“Bluebird In-Licensed IP” means all Patents, Materials and Know-How in-licensed by Bluebird pursuant to Applicable Bluebird In-Licenses, including any extensions or expansions of the scope thereof. 

1.6 “Bluebird Licensed IP” means all (i) Patents, Materials and Know-How Controlled at any time by Bluebird or any
of its Affiliates (including any applicable Collaboration IP and Bluebird Technology) other than pursuant to an Applicable Bluebird In-License and (ii) Bluebird In-Licensed IP, in each case to the extent necessary or useful to Develop Elected
Candidate and Develop and Commercialize Licensed Product. 
 1.7 “Bluebird Regulatory Rights” means all
Regulatory Data, Regulatory Filings and Regulatory Approvals for Elected Candidate and Licensed Product worldwide Controlled at any time by Bluebird or any of its Affiliates. 
 1.8 “Bluebird Technology” means all Bluebird Solely Owned IP and all of Bluebird’s right, title and interest in and to Joint IP. 

1.9 “Celgene Licensed IP” means (i) Celgene Licensed Product IP, and (ii) Celgene Licensed Product In-Licensed
IP. 
 1.10 “Celgene Licensed Product In-License” means [***] 

1.11 “Celgene Licensed Product In-Licensed IP” means [***] 

1.12 “Celgene Licensed Product IP” means [***] 
 1.13 “Celgene Other In-License” means [***] 
 1.14
“Celgene Regulatory Rights” means all Regulatory Data, Regulatory Filings and Regulatory Approvals for Elected Candidate and Licensed Product worldwide Controlled at any time by Celgene or any of its Affiliates. 

1.15 “Celgene Technology” means all Celgene Solely Owned IP and all of Celgene’s right, title and interest in and
to Joint IP. 
 1.16 “Commercialization” means any and all activities directed to the Manufacturing, marketing,
detailing, promotion and securing of reimbursement of a product after Regulatory Approval has been obtained (including making, having made, using, importing, selling and offering for sale such product), and will include post-approval clinical
studies, post-launch 

  
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AS AMENDED. 
  

 
marketing, promoting, detailing, marketing research, distributing, customer service, administering and commercially selling such product, importing, exporting or transporting such product for
commercial sale, and all regulatory compliance with respect to the foregoing. 
 1.17 “Commercially Reasonable
Efforts” means, with respect to the Development or Commercialization of Licensed Product by a Party, that level of efforts and resources that such Party would normally devote to the Development or Commercialization, as the case may be, of a
product owned by it or to which it has rights of the type it has hereunder, which is of a similar commercial potential at a similar stage in its lifecycle, in each case taking into account issues of safety and efficacy, product profile, the
proprietary position, the then current competitive environment for such product and the likely timing of such product’s entry into the market, the pricing and launching strategy for the respective product, the regulatory environment and status
of such product, and other relevant scientific, technical and commercial factors. 
 1.18 “Control” or
“Controlled” means, with respect to any Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals, the possession (whether by ownership or license, other than by a license or sublicense granted
pursuant to this CCPS Agreement) by a Party or its Affiliates of the ability to grant to the other Party a license or access as provided herein to such item, without violating the terms of any agreement or other arrangement with any Third Party or,
other than under Applicable Bluebird In-Licenses, being obligated to pay any royalties or other consideration therefor (“Additional Payments”). For clarity, Other In-Licenses are not “Controlled” for purposes of this CCPS
Agreement, unless and only after such Other In-License is converted into an Applicable New In-License pursuant to Section 10.7(b). Notwithstanding the foregoing, as provided in Section 10.7(a), if on or after the CCPS Agreement Effective
Date and for such time as the other Party agrees to pay and does in fact pay all Additional Payments with respect to such Party’s access or license to any Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals
(other than that in-licensed by Bluebird pursuant to an Other In-License), such Know-How, Material, Patent, Regulatory Data, Regulatory Filings and Regulatory Approvals will be deemed to be included in the definition of “Control”.

 1.19 “Covers”, with reference to (i) a Patent, means that the making, using, selling, offering for sale
or importing of a product or practice of a method would infringe a Valid Claim of such Patent in the country in which such activity occurs, and (ii) Materials or Know-How, means that the Manufacture, Development or Commercialization of a
product incorporates, embodies or otherwise makes use of such Materials or Know-How. 
 1.20 “EU” means the
organization of member states of the European Union as it may be constituted from time to time. 
 1.21 “EU Regulatory
Event” means, with respect to a Licensed Product, the earlier to occur of [***] 
 1.22 “First Commercial
Sale” means [***] 
 1.23 “First Indication” means [***] 

1.24 “GAAP” means U.S. generally accepted accounting principles or International Financial Reporting Standards,
consistently applied, as designated and used by the applicable Party. 

  
 3 

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AS AMENDED. 
  

 1.25 “In-License Payments” means any amounts paid or payable under any
Applicable Bluebird In-License that are incurred by Bluebird solely and directly as a result of the grant of a sublicense thereunder under this CCPS Agreement to Celgene, any of Celgene’s contract Third Parties under Section 10.5, or any
further Sublicensees of Celgene (including of Celgene’s Affiliates that are granted sublicenses) under this CCPS Agreement. Any such payments will include (i) any amounts paid or payable under any Applicable Bluebird In-License solely and
directly as a result of the grant of a sublicense (or an option thereto) by Bluebird to Celgene, [***] 
 1.26 “Licensed
IP” means Bluebird Licensed IP and Celgene Licensed IP. 
 1.27 “Licensed Product” means any product
that constitutes or incorporates an Elected Candidate (including all modified and improved versions thereof), in all forms, presentations, and formulations (including manner of delivery and dosage). A modified or improved version of an Elected
Candidate constituted or incorporated in a product will be deemed a “Modified Licensed Product” for purposes of Section 11.2 if it is Covered by patentable technology Controlled by Bluebird that (i) is first discovered,
created, conceived, developed or reduced to practice after the later of (a) the CCPS Agreement Effective Date and (b) the end of the Collaboration Program Term, (ii) requires the submission of a new BLA with respect to such modified
or improved Elected Candidate, and (iii) materially contributes to the Elected Candidate being approved for a new indication or new patient population. For clarity, “Modified Licensed Products” are Licensed Products hereunder for all
purposes other than Section 11.2. 
 1.28 “Manufacturing” means the production, manufacture, processing,
filling, finishing, packaging, labeling, shipping and holding of product or any intermediate thereof, including process development, process qualification and validation, scale-up, commercial manufacture and analytic development, product
characterization, stability testing, quality assurance and quality control. With reference to Elected Candidate and Licensed Product, Manufacturing includes Vector and associated Payload supply. 

1.29 “Net Sales” means [***] 
 1.30 “Pivotal Study” means (i) a Phase 3 Study that is intended by Celgene to be submitted (together with any other registration trials that are prospectively planned when such Phase
3 Study is initiated) for Regulatory Approval in the U.S. or the EU, or (ii) any other clinical study that is designed to establish that a pharmaceutical product is safe and efficacious for its intended use, and to determine warnings,
precautions, and adverse reactions that are associated with such pharmaceutical product in the dosage range to be prescribed, which clinical study is a registration trial intended to be sufficient for filing an application for a Regulatory Approval
for the Licensed Product in the U.S. or another country or some or all of an extra-national territory, solely as evidenced by the acceptance for filing for a Regulatory Approval for such product after completion of such study. 

1.31 “Regulatory Exclusivity Period” means with respect to a Licensed Product in a country, the period of time during
which (a) Celgene or any of its Affiliates or Sublicensees has been granted the exclusive legal right by a Regulatory Authority (or is otherwise entitled to the 

  
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AS AMENDED. 
  

 
exclusive legal right by operation of Law) in such country to market and sell the Licensed Product, or (b) the data and information submitted by Celgene or any of its Affiliates or
Sublicensees to the relevant Regulatory Authority in such country for purposes of obtaining Regulatory Approval may not be disclosed, referenced or relied upon in any way by such Regulatory Authority (including by relying upon the Regulatory
Authority’s previous findings regarding the safety or effectiveness of the Licensed Product) to support the Regulatory Approval or marketing of any product by a Third Party in such country. 

1.32 “ROW” means the world other than the United States. 

1.33 “ROW Administration” means administration of Licensed Product to a patient when located in the ROW. 

1.34 “ROW Development & Commercialization Program” means the program under this CCPS Agreement for the
Development of Elected Candidate and Licensed Product in the ROW, the Commercialization of Licensed Product in the ROW, and all Manufacturing (including Manufacturing of Vectors and associated Payloads) therefor. 

1.35 “ROW Development Plan” means the Development plan for the Development of Elected Candidate and Licensed Product for
ROW Administration during a given calendar year and the two (2) succeeding calendar years. 
 1.36 “Second
Indication” means [***] 
 1.37 “Selling Party” means a Party and its Sublicensees (including such
Party’s Affiliates that are granted sublicenses pursuant to Section 10.3(c)). 
 1.38 “Sublicensee”
means any person or entity (including Affiliates of the applicable Party) that is granted a sublicense as permitted by Section 10.3 (or an option to take such a sublicense), either directly by a Party or indirectly by any other Sublicensee
hereunder. 
 1.39 “U.S. Administration” means administration of Licensed Product to a patient when located in
the United States. 
 1.40 “U.S. Commercialization Budget” means the budget for conducting Commercialization in
accordance with the U.S. Commercialization Plan during a given calendar year and the two (2) succeeding calendar years, as approved by the JGC in accordance with Section 5.3. 

1.41 “U.S. Commercialization Plan” means that portion of the Worldwide Commercialization Plan that specifies the
Commercialization plan for the Commercialization of Licensed Product for U.S. Administration during a given calendar year and the two (2) succeeding calendar years. 
 1.42 “U.S. Development Budget” means the budget for conducting Development of Elected Candidate and Licensed Product for U.S. Administration pursuant to the U.S. Development Plan during a
given calendar year and the two (2) succeeding calendar years, as approved by the JGC in accordance with Section 4.3. 

1.43 “U.S. Development Plan” means the Development plan for the Development of Elected Candidate and Licensed Product
for U.S. Administration during a given calendar year and the two (2) succeeding calendar years, as approved by the JGC in accordance with Section 4.2. 

  
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AS AMENDED. 
  

 1.44 “U.S. Development & Commercialization Program” means the
program under this CCPS Agreement for the Development of Elected Candidate and Licensed Product in the United States, the Commercialization of Licensed Product in the United States, and all Manufacturing (including Manufacturing of Vectors and
associated Payloads) therefor. 
 1.45 “Valid Claim” means, with respect to a particular country, (i) any
claim of an issued and unexpired Patent in such country that (a) has not been held revoked, unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction, which decision is unappealable or unappealed within
the time allowed for appeal and (b) has not been abandoned, disclaimed, denied or admitted to be invalid or unenforceable through reissue or disclaimer or otherwise in such country, or (ii) a claim of a pending Patent application that has
not been finally abandoned or finally rejected or expired and which has been pending [***] from the date of filing of the earliest priority Patent application to which such pending Patent application is entitled to claim benefit. 

1.46 “Vector Supplies” means supplies of Vectors and associated Payloads Manufactured for incorporation into Elected
Candidate and Licensed Product for Development or Commercialization thereof. 
 1.47 “Worldwide Commercialization
Plan” means the Commercialization Plan that specifies the Commercialization plan for the Commercialization of Licensed Product for U.S. Administration and ROW Administration during a given calendar year and the two (2) succeeding
calendar years. 
 1.48 “Worldwide Manufacturing Plan” means the Manufacturing plan for the Elected Candidate
and Licensed Product for Development for both U.S. Administration and ROW Administration. 
 Definitions for each of the following terms are
found in the body of this CCPS Agreement or the Appendices hereto as indicated below: 
  

			
	 Defined Terms
	 	 Location

	Additional Bluebird IP	 	Section 10.7(a)
	Allowable Expenses	 	Appendix F
	Allocable Manufacturing Overhead	 	Appendix D
	Allocable Overhead	 	Appendix F
	[***]	 	
	[***]	 	
	Bluebird Indemnitees	 	Section 11.6(a)
	Budgeted U.S. Development Costs	 	Section 4.3
	Business Acquisition	 	Section 10.4
	Business Party	 	Section 10.4
	Business Program	 	Section 10.4
	CCPS Agreement Term	 	Section 12.1
	Celgene Indemnitees	 	Section 11.6(b)

  
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AS AMENDED. 
  

			
	 Defined Terms
	 	 Location

	Commercial Supplies	 	Appendix D
	Competitive Infringement	 	Section 14.1
	[***]	 	
	Cost of Goods Sold or COGS	 	Appendix F
	[***]	 	
	Development & U.S. Commercialization Program	 	Section 8.3(a)
	Distribution Costs	 	Appendix F
	Elected Candidate	 	Appendix A
	Fully Burdened Manufacturing Cost	 	Appendix D
	Gross Profit	 	Appendix F
	Gross Sales	 	Appendix F
	Indemnification Claim Notice	 	Section 11.6(c)
	Indemnified Party	 	Section 11.6(c)
	Information Request	 	Section 5.6(g)
	JGC	 	Section 3.1(a)
	Joint IP	 	Section 12.2
	Losses	 	Section 11.6(a)
	Major EU Countries	 	Section 1.21
	Manufacturing and Supply Agreement	 	Section 7.4(b)(ii)
	Marketing Costs	 	Appendix F
	Milestone Event	 	Section 11.2(a)
	Milestone Payment	 	Section 11.2(a)
	Modified Licensed Product	 	Section 1.24
	[***]	 	
	Operating Profits or Losses	 	Appendix F
	Other Operating Income/Expense	 	Appendix F
	Profit & Loss Share	 	Section 11.4
	ROW Post-Approval Manufacturing Plan	 	Section 7.3
	Sales Costs	 	Appendix F
	Sales Returns and Allowances	 	Appendix F
	Solely Owned IP	 	Section 12.1
	Specific Patent	 	Section 13.3
	Third Party Claims	 	Section 11.6(a)
	U.S. Administration Liabilities	 	Section 16.8
	U.S. Development Costs	 	Appendix F

  

	2.	Overview. 

 2.1
General. During the CCPS Agreement Term, the Parties will conduct the Development and Commercialization of Elected Candidate and Licensed Product worldwide on the terms and conditions set forth in this CCPS Agreement. 

  
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AS AMENDED. 
  

 2.2 Roles and Responsibilities; Diligence. 

(a) The JGC will assign to each Party roles and responsibilities for performing the U.S. Development & Commercialization Program.
Each Party, directly or through one or more of its Affiliates, Sublicensees or permitted subcontractors, will use Commercially Reasonable Efforts to perform the obligations assigned to such Party by the JGC under the U.S. Development &
Commercialization Program. Each Party will reasonably cooperate with the other Party in performing such obligations. 
 (b)
Celgene will assume sole responsibility for, and control of, Developing Elected Candidate and Licensed Product in the Field outside of the United States, and will establish a ROW Development & Commercialization Program for that purpose.
Bluebird will reasonably cooperate with Celgene in such ROW Development & Commercialization Program. 
 2.3
Technical Assistance. During the Collaboration Program Term, Bluebird will reasonably cooperate with Celgene to provide all technical assistance, and to transfer to Celgene any additional Know-How licensed to Celgene under Section 10.1,
requested by Celgene to facilitate the transfer of Development efforts related to Elected Candidate and Licensed Product. Such cooperation will include providing Celgene with reasonable access by teleconference or in-person at Bluebird’s
facilities to Bluebird personnel involved in the research and Development of Elected Candidate to provide Celgene with a reasonable level of technical assistance and consultation in connection with the transfer of such Know-How. Following the
Collaboration Program Term, Bluebird will reasonably cooperate with Celgene to provide reasonable amounts of technical assistance, including to transfer to Celgene any additional Know-How licensed to Celgene under Section 10.1, with respect to
Elected Candidate or Licensed Product as reasonably requested by Celgene with reasonable advance notice to Bluebird. Any dispute with respect to the amount and completeness of the technical assistance and cooperation to be provided by Bluebird under
this Section 2.3 will be referred to and finally resolved by binding arbitration by a mutually agreeable, disinterested, conflict-of-interest-free individual not affiliated or consulting with either Party. Any such arbitration will be conducted
under the then-current rules of the American Arbitration Association. 
  

	3.	Governance and Joint Governance Committee. 

 3.1 Joint Governance Committee. 
 (a) Governance Committee. As soon
as practicable following the CCPS Agreement Effective Date, the Parties will establish a Joint Governance Committee, comprised of three (3) representatives of Bluebird and three (3) representatives of Celgene
(the “JGC”). Each Party may replace its representatives on the JGC or its Program Director at any time upon written notice to the other Party. With the consent of the other Party (such consent not to be unreasonably withheld,
delayed or conditioned), each Party may invite non-voting employees and consultants to attend meetings of the JGC, subject to their agreement to be bound to the same extent as a permitted subcontractor under Section 2.4. 

(b) Meetings. While in existence, the JGC will meet each calendar quarter and, at a minimum, two (2) of such meetings each
calendar year will be in person (which in-person meeting will be held at locations mutually agreed by the Parties). In addition, either Party can 

  
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AS AMENDED. 
  

 
call a meeting of the JGC on five (5) business days prior written notice. Meetings of the JGC will be effective only if at least one (1) representative of each Party is present or
participating. Each Party will be responsible for all of its own expenses of participating in the meetings. The Parties will endeavor to schedule the calendar quarterly meetings of the JGC at least six (6) months in advance. The Parties will
alternate in preparing and circulating a meeting agenda prior to each such meeting. The Party that prepared the agenda (or called the meeting) will prepare written minutes of such meeting, and the preparing Party will circulate such minutes within
fifteen (15) days after such meeting. The Parties will agree on the minutes of each meeting promptly, but in no event later than the next meeting of the JGC. 
 (c) Responsibilities. The JGC will supervise the overall performance of the Development and Commercialization of Elected Candidate and Licensed Product for U.S. Administration, and within such
scope will: 
 (i) Make all decisions regarding the Parties’ performance of the U.S. Development &
Commercialization Program (except as otherwise expressly provided in this CCPS Agreement), including, subject to Section 2.2, which Party will have which responsibilities under the U.S. Development & Commercialization Program (taking
into account each Party’s reasonably available resources and expertise (either directly or through Third Party contracting)); 
 (ii) Review and seek to coordinate the U.S. Development & Commercialization Program with the ROW Development & Commercialization Program; 

(iii) Address all matters specifically delegated to the JGC pursuant to this CCPS Agreement; 

(iv) Form such other committees as the JGC may deem appropriate, and require that such committees meet at such times and places,
provided that such committees may make recommendations to the JGC but may not be delegated JGC decision-making authority; 

(v) Address such other matters relating to the activities of the Parties under this CCPS Agreement as either Party may bring before the
JGC, including any matters that are expressly for the JGC to decide as provided in this CCPS Agreement; and 
 (vi) Attempt to
resolve any disputes on an informal basis. 
 (d) Decision-making. The three (3) JGC representatives of each Party
will collectively have one (1) vote, and the JGC will make decisions only by unanimous consent of each Party with respect to its vote, and each Party will act reasonably in exercising its vote. [***] 

(e) Limits on JGC Authority. Each Party will retain the rights, powers and discretion granted to it under this CCPS Agreement and
no such rights, powers, or discretion will be delegated to or vested in the JGC unless such delegation or vesting of rights is expressly provided for in this CCPS Agreement or the Parties expressly so agree in writing. The JGC will not have the
power to, nor will the Party having the tie-breaking vote in the JGC have the power to (i) amend, modify or waive compliance with this CCPS Agreement (other than as expressly permitted hereunder), (ii) alter, increase or expand the
Parties’ rights or obligations under this CCPS Agreement (other than as permitted by Section 2.2), (iii) determine that a Party has 

  
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AS AMENDED. 
  

 
fulfilled any obligations under this CCPS Agreement or that a Party has breached any obligation under this CCPS Agreement, (iv) make a decision that is expressly stated to require the mutual
agreement of the Parties, or (v) determine that milestone events required for the payment of milestone payments have or have not occurred. For avoidance of doubt, the JGC will have no right to supervise or direct the Development and
Commercialization of Elected Candidate or Licensed Product for ROW Administration, and Celgene will have sole decision making authority with respect to such Development and Commercialization, including with respect to the ROW Development &
Commercialization Program. 
 (f) Term. The JGC will cease to exist upon the end of the CCPS Agreement Term, unless the
Parties elect to extend the JGC upon termination of expiration of this CCPS Agreement. 
  

	4.	Development. 

 4.1
Generally. As of and after the CCPS Agreement Effective Date, subject to the terms and conditions of this CCPS Agreement, the Parties will assume through the JGC joint responsibility for Development of Elected Candidate and Licensed Product
for U.S. Administration, under the U.S. Development & Commercialization Program, and Celgene will assume responsibility for Development of Elected Candidate and Licensed Product for ROW Administration, under the ROW Development &
Commercialization Program. Notwithstanding the foregoing, if the initial Phase 1 Study with respect to Optioned Candidate has not been completed as of the CCPS Agreement Effective Date, at Celgene’s election, Bluebird will continue to be
responsible for the performance of such initial Phase 1 Study under the oversight of the JSC under the Master Collaboration Agreement until completion of such initial Phase 1 Study. In the event Bluebird continues, at Celgene’s election, to
continue to be responsible for the performance of such initial Phase 1 Study, Bluebird will be responsible for the costs of performing such initial Phase 1 Study until the earlier to occur of (i) completion of such initial Phase 1 Study and
(ii) expiration or termination of the Collaboration Program Term; following the end of the Collaboration Program Term, Bluebird’s out-of-pocket costs of performing such initial Phase 1 Study incurred after the end of the Collaboration
Program Term will be Development costs hereunder and, (a) if incurred for Licensed Product for U.S. Administration, will be subject to Section 4.3 and Section 11.4, and (b) if incurred for Licensed Product solely for ROW
Administration, Celgene will reimburse Bluebird for such costs within thirty (30) days of Celgene’s receipt of Bluebird’s written invoice therefor. 

  
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AS AMENDED. 
  

 4.2 Development Plan. Promptly after the CCPS Agreement Effective Date, Celgene
will prepare an initial U.S. Development Plan, and the JGC will review and approve such initial U.S. Development Plan, with the goal of coordinating and harmonizing the U.S. Development Plan with the ROW Development Plan. Thereafter, Celgene will
update the U.S. Development Plan each calendar year, and the JGC will review and approve any such update or any other amendment to the U.S. Development Plan. In addition, either Party may request at any time that the JGC consider and approve other
updates to the U.S. Development Plan. Promptly after the CCPS Agreement Effective Date, Celgene will prepare an initial ROW Development Plan and will provide it to the JGC for purposes of discussion and the goal of coordinating and harmonizing the
U.S. Development Plan and the ROW Development Plan. Thereafter, Celgene will update the ROW Development Plan each year and submit it to the JGC for purposes of discussion and the goal of coordinating and harmonizing the U.S. Development Plan and ROW
Development Plan. Notwithstanding anything in this CCPS Agreement to the contrary, the Parties acknowledge and agree that (i) Bluebird may decline to perform any Development activity proposed to be conducted by Bluebird in Worldwide
Commercialization Plan (excluding the completion of a Phase 1 Study pursuant to Section 4.1 and excluding Manufacturing of Vectors and associated Payloads), and (ii) the U.S. Development Plan will not include, and Bluebird will have no
obligation to perform, any such Development activity that Bluebird has declined to perform (other than the completion of a Phase 1 Study pursuant to Section 4.1 and Manufacture of Vectors and associated Payloads), provided that once Bluebird
has agreed to perform a Development activity, it will be obligated to perform, and cannot decline to perform, such activity. Further: 
 (a) The JGC will set the required form and contents of the U.S. Development Plan. The JGC will seek to coordinate and harmonize the U.S. Development Plan and the ROW Development Plan. 

(b) Neither Party (itself or by or through any others, including any Affiliates or Sublicensees) will take any material action regarding
the Development of Elected Candidate or Licensed Product for U.S. Administration unless described in the U.S. Development Plan, provided that the foregoing will not restrict Celgene from taking any action regarding the Development of Elected
Candidate or Licensed Product for ROW Administration. 
 (c) All Development of Elected Candidate and Licensed Product for U.S.
Administration will be conducted under the supervision of the JGC and as part of the U.S. Development & Commercialization Program. 
 (d) All Development of Elected Candidate and Licensed Product for ROW Administration will be conducted under the sole control of Celgene and as part of the ROW Development & Commercialization
Program. At each calendar quarter meeting of the JGC, Celgene will provide the JGC with an update on the Development of Elected Candidate and Licensed Product by Celgene for ROW Administration. During such meeting, Celgene will disclose to Bluebird
all material information regarding such Development. 
 (e) Celgene will prepare and maintain, and will cause its Affiliates and
Sublicensees to prepare and maintain, reasonably complete and accurate records regarding the Development of Elected Candidate and Licensed Product for ROW Administration. At each calendar quarter

  
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AS AMENDED. 
  

 
meeting of the JGC, Celgene will provide the JGC with a reasonably detailed report regarding such efforts. Such report will contain sufficient detail to enable Bluebird to assess Celgene’s
compliance with its Development and Commercialization obligations hereunder, including information with respect to the following: (i) the design, status and results of any animal studies and clinical trials for Licensed Product; and
(ii) any regulatory milestones, and any Regulatory Approvals achieved, for Licensed Product. In addition to the foregoing, Celgene will provide Bluebird with such additional information regarding any such activities as Bluebird may reasonably
request from time to time. 
 4.3 Development Budget and Costs. Promptly after the CCPS Agreement Effective Date, and
concurrently with the preparation of the U.S. Development Plan, Celgene will prepare an initial U.S. Development Budget, which U.S. Development Budget will specify estimated U.S. Development Costs for each calendar year covered by such U.S.
Development Budget (as updated pursuant to the following sentence, the “Budgeted U.S. Development Costs”), and the JGC will review and approve, where practicable, such initial U.S. Development Budget at least six (6) months in
advance of such U.S. Development Costs being incurred. [***] 
  

	5.	Commercialization. 

5.1 Generally. Subject to the terms and conditions of this CCPS Agreement, (i) the Parties will assume through the JGC joint
responsibility for Commercialization of Licensed Product for U.S. Administration under the U.S. Development & Commercialization Program, and (ii) Celgene will assume sole responsibility for Commercialization of Licensed Product for ROW
Administration (including all costs and expenses arising therefrom). 
 5.2 Commercialization Plan. At such times as the
JGC will deem appropriate, the JGC will direct the Parties to mutually prepare a Worldwide Commercialization Plan, and the JGC will review and approve such initial Worldwide Commercialization Plan. Thereafter, the JGC will have one or the other
Party (or both) update the Worldwide Commercialization Plan each calendar year, and the JGC will review and approve any such update or any other amendment to the Worldwide Commercialization Plan. Notwithstanding anything in this CCPS Agreement to
the contrary, the Parties acknowledge and agree that (i) Bluebird may decline to perform any Commercialization activity proposed to be conducted by Bluebird in the Worldwide Commercialization Plan (other than Manufacturing of Vectors and
associated Payloads), and (ii) the Worldwide Commercialization Plan will not include, and Bluebird will have no obligation to perform, any such Commercialization activity that Bluebird has declined to perform, provided that once Bluebird has
agreed to perform a Commercialization activity, it will be obligated to perform, and cannot decline to perform, such activity. In addition, either Party may request at any time that the JGC consider and approve other updates to the Worldwide
Commercialization Plan. Further: 
 (a) The JGC will set the required form and contents of the Worldwide Commercialization Plan.
The Worldwide Commercialization Plan will reflect a singular marketing and sales approach worldwide, and will specify, among other things, the number of sales reps in the U.S. for each Party, allocation of regions in the U.S. for each Parties’
sales force, creation of marketing materials, planning for conferences, and other marketing activities. 

  
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AS AMENDED. 
  

 (b) Neither Party (itself or by or through any others, including any Affiliates or
Sublicensees) will take any material action regarding the Commercialization of Licensed Product unless described in the Worldwide Commercialization Plan or approved by the JGC. 

(c) All Commercialization of Licensed Product for U.S. Administration will be conducted under the supervision of the JGC and as part of
the U.S. Development & Commercialization Program. 
 (d) Celgene will have final decision making authority for all
Commercialization activities worldwide, including timing of launch and pricing and the Worldwide Development Plan. 
 5.3
U.S. Commercialization Budget. At such times as the JGC will deem appropriate, and concurrently with the preparation of the initial Worldwide Commercialization Plan, Celgene will prepare an initial U.S. Commercialization Budget, and the JGC
will review and approve such initial U.S. Commercialization Budget. [***] 
 5.4 Commercialization in the ROW. Celgene,
directly or through one or more of its Affiliates or Sublicensees, will use Commercially Reasonable Efforts, (i) to Develop Licensed Product in the Field for ROW Administration and to obtain Regulatory Approvals therefor; and (ii) to
Commercialize Licensed Product in the Field for ROW Administration after obtaining such Regulatory Approval, in each country in the ROW where Commercializing Licensed Product would be warranted by using Commercially Reasonable Efforts. 

5.5 Branding. Subject to further mutual written agreement of the Parties, to the extent permitted by applicable Law and applicable
Regulatory Authorities, (i) all Licensed Product sold or distributed for U.S. Administration will have the corporate brands of each Party displayed on an equally prominent basis, and (ii) all Licensed Product sold or distributed for ROW
Administration will have the corporate brand of Bluebird displayed on a reasonably prominent basis. At such time as the JGC will deem appropriate, the Parties will enter into appropriate trademark licensing agreements to achieve the foregoing.

 5.6 Training; Details. 
 (a) Celgene will direct the training of both Parties’ sales representatives and will prepare and implement, in consultation with Bluebird, a training program and training materials for such sales
representatives. In addition, Celgene will specify the conduct and content of details (including detail scripts) for the Licensed Product. Bluebird will cause each of its sales representatives assigned to promote the Licensed Product to attend and
complete the training program developed by Celgene for the Licensed Product in the United States to assure a consistent, focused promotional strategy and message as and to the extent consistent with applicable Law. 

(b) Each Party will be solely responsible for recruiting, hiring and maintaining its sales force of sales representatives for promotion
of the Licensed Product in accordance with its standard procedures and the requirements of this CCPS Agreement. Each Party will be responsible for the activities of its sales representatives, including compliance by its sales representatives with
training and detailing requirements. In particular, each Party will provide its sales representatives assigned to promote the Licensed Product with the level of oversight, 

  
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AS AMENDED. 
  

 
management, direction and sales support with respect to the promotion of Licensed Product necessary to effectively and efficiently promote the Licensed Product in accordance with the terms of
this CCPS Agreement and applicable Law. If Celgene raises any concern with Bluebird regarding the performance or fitness of any Bluebird sales representative, Bluebird will address such concerns in a manner consistent with Celgene’s
instructions, including removal of such sales representative from the promotion of the Licensed Product. 
 (c) Each
Party’s sales representatives assigned to promote the Licensed Product will utilize only promotional materials that have been approved by the JGC. All detailing activities conducted by each Party’s sales representatives will be consistent
in all material respects with the promotional materials so approved. Each Party will train and instruct their respective sales representatives to make only those statements and claims regarding the Licensed Product, including as to efficacy and
safety, that are consistent with the Licensed Product labeling and accompanying inserts and the approved promotional materials. 

(d) Bluebird will have the right, but not the obligation, to provide [***] of the total sales representatives used by both Parties for
promotion of Licensed Product. The Worldwide Commercialization Plan will set forth the precise number of Bluebird sales representatives consistent with the foregoing. If Bluebird is not at any particular time able to provide, for any reason, the
number of sales representatives specified in the Worldwide Commercialization Plan, then Celgene will have the right to make up such shortfall using its sales representatives until such time as Bluebird is able to provide its agreed upon number of
sales representatives. Bluebird will engage sales representatives having the minimum qualifications set forth in Schedule 5.6. [***] 
 (e) Each Party will provide the JGC with a report, as soon as practicable but in no event later than forty-five (45) days following the end of each calendar quarter during the Term, setting forth the
number of details made by its sales representatives of Licensed Product in the United States during such calendar quarter. Costs and expenses for sales representatives will be charged to the Profit & Loss Share on an FTE basis. 

(f) Each Party will maintain records and otherwise establish procedures to ensure compliance with all applicable Laws and professional
requirements that apply to the promotion and marketing of the Licensed Product, including compliance with the PhRMA Code on Interactions with Healthcare Professionals. 
 (g) Celgene will have sole authority to execute medical and scientific affairs and programs, including professional symposia and other educational activities, and medical affairs studies based upon
approved protocols. Celgene will have sole authority over all medical affairs activities relating to the Licensed Product, including medical information support and medical communications and publishing activities. The Parties acknowledge that each
Party may receive requests for medical information concerning the Licensed Product from members of the medical professions and consumers. Celgene will have the exclusive right to respond to questions and requests for information about the Licensed
Product received from such Persons that (i) warrant a response beyond the understanding of the sales representatives or (ii) are beyond the scope of the Licensed Product labels and inserts (each such request, an “Information
Request”). If Information Requests are received by Bluebird, the request will be referred to Celgene’s medical information department or appointed Third Party vendor to which Celgene has instructed Bluebird in writing to refer
Information Requests. 

  
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AS AMENDED. 
  

	6.	Regulatory. 

 6.1
Generally. Subject to Section 6.2 and the last sentence of Section 4.1, as of and after the CCPS Agreement Effective Date, subject to the terms and conditions of this CCPS Agreement, the Parties will assume through the JGC joint
responsibility for all regulatory matters regarding seeking Regulatory Approval for Elected Candidate and Licensed Product for U.S. Administration, including interacting with Regulatory Authorities in connection therewith, before and after
Regulatory Approval of Licensed Product. Celgene will have sole responsibility for all regulatory matters regarding seeking Regulatory Approval for Elected Candidate and Licensed Product for ROW Administration, including interacting with Regulatory
Authorities in connection therewith, before and after Regulatory Approval of Licensed Product. Further: 
 (a) Prior to
Regulatory Approval of Licensed Product for U.S. Administration, any such regulatory activities for Elected Candidate and such Licensed Product will be included in and will be part of the U.S. Development Plan (and thus subject to
Section 4.2(a)) and the U.S. Development & Commercialization Program. 
 (b) Prior to Regulatory Approval of
Licensed Product for ROW Administration, any such regulatory activities for Elected Candidate and such Licensed Product will be included in and will be part of the ROW Development Plan and the ROW Development & Commercialization Program.

 (c) After any such Regulatory Approval for such Licensed Product for U.S. Administration, any such regulatory activities for
U.S. Administration will be included in and will be part of the Worldwide Commercialization Plan and the U.S. Development & Commercialization Program. 
 (d) After any such Regulatory Approval for such Licensed Product for ROW Administration, any such regulatory activities for ROW Administration will be included in and will be part of the Worldwide
Commercialization Plan and the ROW Development & Commercialization Program. 
 (e) Neither Party (itself or by or
through any others, including any Affiliates or Sublicensees) will take any material action regarding any such regulatory activities unless described in the U.S. Development Plan, ROW Development Plan or the U.S. Commercialization Plan. 

(f) Celgene will deploy and administer any REMS or other safety monitoring activity implemented for the Licensed Product, and be
responsible for all pharmacovigilance activities for the Licensed Product. 
 6.2 Roles. Subject to Section 6.1,
Celgene will take the lead and have final authority with respect to any regulatory activities for seeking Regulatory Approval for Elected Candidate and Licensed Product worldwide. Bluebird will have the right (i) to review and provide comments
on all Regulatory Data, Regulatory Filings and Regulatory Approvals for U.S. Administration regarding such activities, which comments will be included if reasonable, and (ii) participate in all meeting with any Regulatory Authorities in the
United States regarding such activities. 

  
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AS AMENDED. 
  

 6.3 Ownership. All Regulatory Filings for Elected Candidate and Licensed Product
worldwide will be made by Celgene, in Celgene’s name, and all Regulatory Filings and Regulatory Approvals for Elected Candidate and Licensed Product worldwide will be solely owned by Celgene. 

 

	7.	Manufacture and Supply. 

 7.1 Generally. As of and after the CCPS Agreement Effective Date, subject to the terms and conditions of this CCPS Agreement, (i) the Parties will assume through the JGC joint responsibility
for (1) Manufacture of Elected Candidate and Licensed Product for Development and (2) Manufacture of Licensed Product for Commercialization for U.S. Administration, each under the Development & U.S. Commercialization Program, and
(ii) Celgene will assume sole responsibility for Manufacturing Licensed Product for Commercialization for ROW Administration and, subject to Section 7.4, Celgene will purchase Vector Supply from Bluebird or its designee for such purpose.

 7.2 Manufacturing for Development and Commercialization for U.S. Administration. Prior to Regulatory Approval of
Licensed Product in any country, any Manufacturing activities for Development of Elected Candidate and such Licensed Product will be included in and will be part of the Worldwide Manufacturing Plan. After any such Regulatory Approval for such
Licensed Product in the United States, any Manufacturing activities for Commercialization of Licensed Product for U.S. Administration will be included in and will be part of the U.S. Commercialization Plan and the U.S. Development and
Commercialization Program. Neither Party (itself or by or through any others, including any Affiliates or Sublicensees) will take any material action regarding any such Manufacturing activities unless described in the Worldwide Manufacturing Plan or
the U.S. Commercialization Plan, unless approved by the JGC. 
 7.3 Manufacturing for ROW Administration. Prior to
Regulatory Approval of Licensed Product in any country in the ROW, Celgene will provide to the JGC a Manufacturing plan for the ROW in form and substance at least as detailed as the applicable section of the U.S. Commercialization Plan (including
covering the applicable three-year time period) (the “ROW Post-Approval Manufacturing Plan”). Celgene (itself or by or through any others, including any Affiliates or Sublicensees) will not materially deviate from the then
current ROW Post-Approval Manufacturing Plan when Manufacturing Licensed Product for Commercialization for ROW Administration without first notifying the JGC in writing and providing an updated ROW Post-Approval Manufacturing Plan. 

7.4 Vector Manufacturing. Notwithstanding this Section 7: 

(a) Generally. Bluebird will have the sole right to Manufacture Vector Supply for the Development and Commercialization of Elected
Candidate and Licensed Product worldwide, and Celgene will have no rights with respect thereto except as provided in Section 7.4(b)(iv). Except as provided in Section 7.4(b)(iv) or in the Manufacturing Supply Agreement, neither Celgene nor
any Affiliate of Celgene (nor any others on behalf of or under license or sublicense from Celgene or any of its Affiliates) will Manufacture (i) any Vector and associated Payload for Licensed Product or (ii) Licensed Product, except for
the Manufacture of Licensed Product using Vector Supply supplied by or on behalf of Bluebird. Except as provided in Section 7.4(b)(iv) or in the Manufacturing Supply Agreement, Celgene and its Affiliates and Sublicensees will purchase all
Vector Supply exclusively from Bluebird or its designee. 

  
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AS AMENDED. 
  

 (b) Vector Supply Terms. 

(i) Except as provided in this Section 7.4(b)(iv) or in the Manufacturing Supply Agreement, Bluebird and its Affiliates will
Manufacture, or cause a Third Party to Manufacture, all Vector Supply for all Elected Candidate and Licensed Product required for clinical Development and Commercialization in the Field worldwide, and will have the right to make all necessary
decisions regarding arrangements with Third Party manufacturers, provided that Bluebird will reasonably consult with Celgene with respect to all such arrangements and obtain Celgene’s prior written consent, which will not be unreasonably
withheld, conditioned or delayed. [***] 
 (ii) The Parties will enter into a “Manufacturing and Supply Agreement,”
between each other or among the Parties and an Affiliate or a Third Party, covering Vector Supply as soon as reasonably practicable after the CCPS Agreement Effective Date, which agreement will be consistent with and supersede the terms of this
Section 7.4(b) and will otherwise be subject in all respects to the terms and conditions of this CCPS Agreement. 
 (iii)
The cost to Celgene of Vector Supply for Commercialization for ROW Administration will equal [***], unless otherwise agreed by the Parties in writing. The cost of Vector Supply for Commercialization for U.S. Administration will be included in the
Cost of Goods Sold. The cost of Vector Supply for Development will be included in the U.S. Development Costs, subject to adjustment as provided therein. 
 (iv) The Manufacturing and Supply Agreement will include the terms set forth in Appendix I, including terms permitting Celgene to establish “back-up” and/or “second source”
rights for Vector Supply and license grants from Celgene to Bluebird under the Celgene Licensed IP to the extent necessary or useful for Bluebird to Manufacture Vector Supply. [***] 

(v) At Celgene’s request, Bluebird will cooperate with Celgene’s reasonable requests, at Celgene’s cost and expense, to
engage in a technology transfer to allow Celgene, in accordance with Section 7.4(b), to Manufacture Vector Supply (through the first commercial batch of Vector Supply) itself or by through its designated Third Party manufacturer, by
transferring all Know-How, Materials, technology and trade secrets Controlled by Bluebird or its Affiliates that are necessary to Manufacture Vector Supply, thereby enabling Celgene (or such Third Party) to Manufacture the Vector Supply. 

(vi) Any purchase of Vector Supply from Bluebird or its designee will expressly not include any license rights to any Know-How or
Patents, but instead all licenses (implied, by exhaustion or otherwise) will arise under Section 10.1, if and as applicable. 
 (vii) For the purpose of this CCPS Agreement, certain words and phrases (and their correlatives) relating to Manufacturing will have the meanings set forth on Appendix D. 

 

	8.	Supporting Provisions for Development and Commercialization. 

 8.1 Co-Co Licenses. In the event that through the JGC the Parties identify Patents, Know-How or Materials of a Third Party that are necessary to Develop and Commercialize Elected Candidate and
Licensed Product worldwide, upon JGC recommendation, one or the 

  
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AS AMENDED. 
  

 
other Party (or both) will use commercially reasonable efforts to obtain a license or other rights to such Patents, Know-How or Materials for use in connection with the performance of such
Development and Commercialization (“Co-Co In-Licenses”). Prior to entering into any Co-Co In-License, the contracting Party will provide a draft copy to the other Party and the other Party will have the right to review and provide
comments to such proposed Co-Co In-License. Neither Party will enter into a Co-Co In-License without the prior approval of the JGC, provided that Celgene will be free to enter into any Co-Co In-License for ROW Administration notwithstanding this
Section 8.1. If a Party enters into any Co-Co In-Licenses during the CCPS Agreement Term, Appendix F hereto will be updated accordingly to include such Co-Co In-Licenses. 

8.2 Records. Each Party will maintain, or cause to be maintained, records of its activities under this CCPS Agreement
(including the Development & U.S. Commercialization Program) in sufficient detail and in good manner appropriate for research. Development, Commercialization, scientific, Patent and regulatory purposes, that will properly reflect all work
included in the Development & U.S. Commercialization Program and under this CCPS Agreement, for a period of at least ten (10) years after the creation of such records. Each Party will have the right to request a copy of any such
records. 
 8.3 Materials. 
 (a) Each Party will, during the CCPS Agreement Term, as a matter of course under the U.S. Development & Commercialization Program or ROW Development & Commercialization Program
(collectively the “Development & U.S. Commercialization Program”) or upon the other Party’s reasonable written request, furnish to each other samples of Materials that are in such Party’s Control and are necessary
for the other Party to carry out its responsibilities hereunder. 
 (b) Each Party will use such Materials only in accordance
with the Development & U.S. Commercialization Program and otherwise in accordance with the terms and conditions of this CCPS Agreement and any instructions provided by the Party furnishing the Materials. Except with the prior written
consent of the supplying Party (such consent not to be unreasonably withheld, delayed or conditioned), the Party receiving any Materials will not distribute or otherwise allow the release of Materials to any Affiliate (other than wholly-owned
subsidiaries) or Third Party, except for subcontracting as permitted hereunder. All Materials delivered to the receiving Party will remain the sole property of the supplying Party and will be used in compliance with all applicable Law. The Materials
supplied under this CCPS Agreement will be used with prudence and appropriate caution in any experimental work because not all of their characteristics may be known. 
 8.4 Permitted Subcontracting. Each Party may subcontract any of its activities to be performed under the Development & U.S. Commercialization Program to an Affiliate or Third Party,
provided that any such Affiliate or Third Party will have entered into a written agreement with such Party that includes terms and conditions protecting and limiting use and disclosure of Confidential Information and Materials and Know-How at least
to the same extent as under this CCPS Agreement, and requiring such Affiliate or Third Party and its personnel to assign to such Party all right, title and interest in and to any Patents, Know-How and Materials created,

  
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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 
conceived or developed in connection with the performance of subcontracted activities to the extent required to research, Develop, Manufacture and Commercialize Elected Candidate and Licensed
Product, provided that with respect to Third Parties that are academic or other non-commercial Persons, a Party will be required only to use commercially reasonable efforts to obtain such assignment. Any such subcontracting activities will be
described in the reports for the Collaboration Program required by Section 8.5. 
 8.5 Reports. The Parties will
prepare and provide to the other Party such reports regarding their activities under this CCPS Agreement as the JGC may reasonably require. In addition, each Party will disclose to the other Party information regarding those activities as such Party
may reasonable request. Without limiting the foregoing, each Party will prepare and maintain, and will cause its Affiliates and Sublicensees to prepare and maintain, reasonably complete and accurate records regarding the Development of Elected
Candidate and Licensed Product, and Commercialization of Licensed Product worldwide after Regulatory Approval therefor. Each Party will provide to the other Party a reasonably detailed report regarding such efforts at least once every calendar year
(and more frequently if required by the JGC). Such report will contain sufficient detail to enable a Party to assess the other Party’s compliance with its Development and Commercialization obligations hereunder (including under the
Development & U.S. Commercialization Program), including information with respect to the following: (i) the design, status and results of any animal studies and clinical trials for Licensed Product; (ii) any regulatory milestones,
and any Regulatory Approvals achieved, for Licensed Product; and (iii) activities with respect to selling, promoting, supporting, detailing and marketing of Licensed Product. 

 

	9.	In-Licenses. 

 9.1
Applicable Bluebird In-Licenses and Other IP. 
 (a) Maintenance of Applicable Bluebird In-Licenses. Bluebird
(i) will duly perform and observe all of its obligations under the Applicable Bluebird In-Licenses in all material respects and maintain in full force and effect the Applicable Bluebird In-Licenses, and (ii) will not, without
Celgene’s prior written consent (such consent not to be unreasonably withheld, conditioned or delayed), (1) amend, modify, restate, cancel, supplement or waive any provision of any Applicable Bluebird In-License, or grant any consent
thereunder, or agree to do any of the foregoing, or (2) exercise any right to terminate any Applicable Bluebird In-License in each case ((1) and (2)) that would reasonably be expected to adversely affect in any respect the rights of
Celgene under this CCPS Agreement, provided that Bluebird will provide prior written notice to Celgene of all of the foregoing notwithstanding whether or not any of the foregoing would reasonably be expected to adversely affect in any respect the
rights of Celgene under this CCPS Agreement. Bluebird will provide Celgene with written notice as promptly as practicable (and in any event within five (5) business days) after becoming aware of any of the following: (A) any material
breach or default by Bluebird or any of its Affiliates of any covenant, agreement or other provision of any Applicable Bluebird In-License, (B) any notice or claim from the counterparty to any Applicable Bluebird In-License terminating or
providing notice of termination of any Applicable Bluebird In-License, (C) any notice or claim alleging any breach of default under any Applicable Bluebird In-License, or (D) the existence of any facts, circumstances or events which alone
or together with other facts, circumstances or events would 

  
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AS AMENDED. 
  

 
reasonably be expected (with or without the giving of notice or passage of time or both) to give rise to a breach of or default under or right to terminate any Applicable Bluebird In-License. If
Bluebird fails to pay any amounts due under any Applicable Bluebird In-License and if such nonpayment would permit the counterparty to such Applicable Bluebird In-License to terminate or suspend the same or any rights thereunder, Celgene will have
the right, but not the obligation, in its sole discretion, to pay such amounts on Bluebird’s behalf, and any amounts so paid by Celgene may be taken by Celgene as a credit against any amounts payable to Bluebird under this CCPS Agreement.

 (b) Maintenance of Co-Co In-Licenses. The contracting Party to any Co-Co In-License (i) will duly perform and
observe all of its obligations under the Co-Co In-License in all material respects and maintain in full force and effect the Co-Co In-License, and (ii) will not, without the other Party’s prior written consent (such consent not to be
unreasonably withheld, conditioned or delayed), (1) amend, modify, restate, cancel, supplement or waive any provision of any Co-Co In-License, or grant any consent thereunder, or agree to do any of the foregoing, or (2) exercise any right
to terminate any Co-Co In-License in each case ((1) and (2)) that would reasonably be expected to adversely affect in any respect the rights of the non-contracting Party under this CCPS Agreement, provided that the contracting Party will
provide prior written notice to the non-contracting Party of all of the foregoing notwithstanding whether or not any of the foregoing would reasonably be expected to adversely affect in any respect the rights of the non-contracting Party under this
CCPS Agreement. The contracting Party to any Co-Co In-License will provide the other Party with written notice as promptly as practicable (and in any event within five (5) business days) after becoming aware of any of the following:
(A) any material breach or default by such contracting Party or any of its Affiliates of any covenant, agreement or other provision of the Co-Co In-License, (B) any notice or claim from the counterparty to the Co-Co In-License terminating
or providing notice of termination of the Co-Co In-License, (C) any notice or claim alleging any breach of default under the Co-Co In-License, or (D) the existence of any facts, circumstances or events which alone or together with other
facts, circumstances or events would reasonably be expected (with or without the giving of notice or passage of time or both) to give rise to a breach of or default under or right to terminate the Co-Co In-License. If the contracting Party to a
Co-Co In-License fails to pay any amounts due under such Co-Co In-License and if such nonpayment would permit the counterparty to such Co-Co In-License to terminate or suspend the same or any rights thereunder, the other Party will have the right,
but not the obligation, in its sole discretion, to pay such amounts on the other Party’s behalf, and any amounts so paid by such other Party may be taken by such other Party as a credit against any amounts payable to the other Party under this
CCPS Agreement. 
 (c) [***] 
 (d) Applicable Bluebird In-License Requirements. Celgene will abide, and will cause all its Affiliates and applicable Sublicensees to abide, by all requirements of each Applicable Bluebird
In-License in all material respects (and in any case in all respects in the case that failure to so abide would result in a breach under the Applicable Bluebird In-License), to the extent applicable to sublicensees thereunder and to the extent
disclosed by Bluebird to Celgene, with the understanding that disclosure by Bluebird of any Applicable Bluebird In-License to Celgene will be deemed disclosure of such requirements of such Applicable Bluebird In-License to

  
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AS AMENDED. 
  

 
Celgene. In the event of a termination of any Applicable Bluebird In-License, Bluebird agrees, to the extent requested by Celgene, to reasonably assist Celgene in securing a direct license from
the applicable licensor under any Patents, Materials and Know-How that was licensed to Bluebird and sublicensed to Celgene hereunder prior to such termination. In addition, Bluebird agrees, if requested by Celgene, to reasonably assist Celgene in
securing a standby license from the applicable licensor under any Patents, Materials and Know-How that are licensed to Bluebird and sublicensed to Celgene. 
 (e) Applicable Co-Co In-License Requirements. Each non-contracting Party to a Co-Co In-License will abide, and will cause all its Affiliates and applicable Sublicensees to abide, by all
requirements of each such Co-Co In-License in all material respects (and in any case in all respects in the case that failure to so abide would result in a breach under the Co-Co In-License), to the extent applicable to sublicensees thereunder and
to the extent disclosed by the contracting Party to the non-contracting Party, with the understanding that disclosure by the contracting Party of any Co-Co In-License to the non-contracting Party will be deemed disclosure of such requirements of
such Co-Co In-License to the non-contracting Party. In the event of a termination of any Co-Co In-License, the contracting Party agrees, to the extent requested by the non-contracting Party, to reasonably assist the non-contracting Party in securing
a direct license from the applicable licensor under any Patents, Materials and Know-How that was licensed to the contracting Party and sublicensed to the non-contracting Party hereunder prior to such termination. In addition, the contracting Party
agrees, if requested by the non-contracting Party, to reasonably assist the non-contracting Party in securing a standby license from the applicable licensor under any Patents, Materials and Know-How that are licensed to the contracting Party and
sublicensed to the non-contracting Party hereunder. 
 (f) [***] 

 

	10.	License Grants. 

10.1 Development and Commercialization Licenses by Bluebird. Subject to the terms and conditions of this CCPS Agreement, Bluebird
hereby grants to Celgene: 
 (a) a co-exclusive (with Bluebird and its Affiliates) license, with the right to sublicense only as
permitted by Section 10.3, under Bluebird Licensed IP and Bluebird Regulatory Rights, (i) to Develop (including for clarity Manufacture) Elected Candidate and Licensed Product for U.S. Administration and (ii) to Commercialize
(including for clarity Manufacture) Licensed Product for U.S. Administration; 
 (b) a worldwide, exclusive (even as to
Bluebird) license, with the right to sublicense only as permitted by Section 10.3, under Bluebird Licensed IP and Bluebird Regulatory Rights, (i) Develop (including for clarity Manufacture (other than Vectors)) Elected Candidate and
Licensed Product for ROW Administration and (ii) to Commercialize (including for clarity Manufacture (other than Vectors)) Licensed Product for ROW Administration; and 
 (c) a worldwide, co-exclusive (with Bluebird and its Affiliates) license, with the right to sublicense only as permitted by Section 10.3, under Bluebird Licensed IP and Bluebird Regulatory Rights, to
Manufacture Vectors and associated Payloads for Licensed Product for ROW Administration. 

  
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AS AMENDED. 
  

 Further, (i) the foregoing licenses to Bluebird Regulatory Rights include the right to reference
same, (ii) the licenses to Commercialize granted in this Section 10.1 will cover only the sale and offer for sale of Licensed Product in finished form and not the sale or offer for sale of Vectors and associated Payloads (other than as and
to the extent incorporated in the Licensed Product), and (iii) rights to Manufacture Vectors and associated Payloads are included within the scope of the licenses granted to Celgene under this Section 10.1, which rights are subject to the
terms and conditions of Section 7.4(b). 
 10.2 Development and Commercialization Covenant Not To Sue by Celgene.

 (a) Subject to the terms and conditions of this CCPS Agreement, Celgene agrees that neither it nor its Affiliates will sue,
assert any claim against, or otherwise participate in any action or proceeding against Bluebird or any of its Affiliates, sublicensees, contractors (including suppliers and manufacturers) or agents, or cause or authorize any Person to do any of the
foregoing, under the Celgene Licensed IP and Celgene Regulatory Rights, with respect to Bluebird’s (i) Development (including for clarity Manufacture) of Elected Candidate and Licensed Product for U.S. Administration and
(ii) Commercialization (including for clarity Manufacture) of Licensed Product for U.S. Administration, all as part of the Development & U.S. Commercialization Program; and (iii) Manufacture of Vectors and associated Payloads for
Licensed Product for ROW Administration. 
 (b) Celgene will require that any Person that takes after the CCPS Agreement
Effective Date any license or right in or to any Celgene Licensed IP and Celgene Regulatory Rights that is subject to the covenant not to sue in Section 10.2(a) is subject to the covenants not to sue set forth in this Section 10.2.

 For clarity, (i) the foregoing covenants not to sue regarding Celgene Regulatory Rights includes the right to reference same,
(ii) such covenants not to sue with respect to the Commercialization granted in this Section 10.2 will cover only the sale and offer for sale of Licensed Product in finished form, and (iii) Manufacture of Vectors and associated
Payloads is included within the scope of the covenants not to sue granted to Bluebird under this Section 10.2. 
 10.3
Licensing and Sublicensing Rights. 
 (a) Transfer. The licenses and covenants granted in Sections 10.1 and
10.2 are transferable only upon a permitted assignment of this CCPS Agreement in accordance with Section 13.13. 
 (b)
Other Licenses. Either Party can grant licenses to its own Licensed IP to its Affiliates and other Third Parties, subject to the terms of this CCPS Agreement (including the exclusivity and co-exclusivity provided for in the licenses granted
in Sections 10.1 and 10.2). 
 (c) Sublicenses. The licenses and covenants granted in Sections 10.110.2 may be
sublicensed, in full or in part, by the licensee Party by a written agreement to its Affiliates and Third Parties (with the right to sublicense through multiple tiers), provided, that as a condition precedent to and requirement of any such
sublicense: 
 (i) Celgene will obtain Bluebird’s written consent prior to granting to a Third Party any sublicense of the
licenses granted by Bluebird in Section 10.1 with respect to the Development or Commercialization of Licensed Product for U.S. Administration (such consent not to be unreasonably withheld, delayed or conditioned). 

  
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AS AMENDED. 
  

 (ii) Bluebird will obtain Celgene’s written consent prior to granting to a Third
Party any sublicense of the covenant not to sue granted by Celgene in Section 10.2, or any other right to license, with respect to the Development or Commercialization of Licensed Product for U.S. Administration (such consent not to be
unreasonably withheld, delayed or conditioned). 
 (iii) The licensee Party will provide the licensor Party with a copy of any
sublicense agreement with a non-Affiliated Sublicensee within thirty (30) days of execution thereof, and to the extent permitted under any Applicable Bluebird In-License, such sublicense agreement may be redacted as necessary to protect
commercially sensitive information; 
 (iv) The licensor Party will be responsible for any and all obligations of such
Sublicensee as if such Sublicensee were such licensee Party hereunder; 
 (v) Any such Sublicensee will agree in writing to be
bound by substantially identical obligations as such licensee Party hereunder with respect to the activities of such Sublicensee hereunder (and not with respect to the activities of any other), including any Know-How disclosure obligations such
licensee Party has to the licensor Party hereunder with respect to the activities of such Sublicensee hereunder (but excluding payment obligations); and 
 (vi) The licensor Party will be made an express third-party beneficiary of any such Sublicensee’s obligations under such sublicense agreement that relate to compliance with the terms and conditions
of this CCPS Agreement. 
 10.4 Exclusivity. During the CCPS Agreement Term, neither Party nor its Affiliates (nor any
others on behalf of or with, or under license or sublicense from, such Party or any of its Affiliates) will research, Develop, Manufacture or Commercialize any products (including Vectors and associated Payloads) to be used in the Field (which, for
the purposes of this Section 10.4, will include all indications and will not be limited to cancer) that specifically target the same Target Antigen as Elected Candidate, other than pursuant to this CCPS Agreement (which includes, for avoidance
of doubt, research, development, Manufacture and Commercialization of improved and modified versions of the Licensed Product by Celgene) or any other Development & U.S. Commercialization Agreement (if against the same Target Antigen) (which
includes, for avoidance of doubt, research, development, Manufacture and Commercialization of improved and modified versions of the Licensed Product pursuant to this CCPS Agreement). Notwithstanding this Section 10.4, if (i) a Business
Combination occurs with respect to either Party with a Third Party or (ii) a Party acquires a Third Party (including by a merger or consolidation) so that such Third Party becomes an Affiliate over which the acquiring Party has control (as
defined in the definition of Affiliate), or (iii) a Party acquires all or substantially all of the assets of a Third Party (including any Subsidiaries or divisions thereof) (each of (i), (ii) and (iii), a “Business
Acquisition”; such Party, the “Business Party”), and, in each case, the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other
than the Business Party and its Affiliates as of the Business Acquisition) (a) already has, or the acquired assets contain, as applicable, a program that existed prior to, or was planned prior to and is demonstrably to be implemented shortly
after, the Business Acquisition or (b) initiates and pursues a new program following such Business Acquisition, in each case that would otherwise violate this Section 10.4 (a “Business Program”),

  
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AS AMENDED. 
  

 
then such Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than the Business Party and its
Affiliates as of the Business Acquisition), as applicable, will be permitted to initiate, pursue and continue such Business Program after such Business Acquisition and such initiation, pursuit and continuation will not constitute a violation of this
Section 10.4; provided however that (A) none of the Bluebird Licensed IP or Celgene Licensed IP, as the case may be, or other Patents, Materials or Know-How Controlled by the other Party and, in each case, licensed to the Business Party
will be used in the Business Program, and (B) the research or Development activities required under this CCPS Agreement will be conducted separately from any research or Development activities directed to such Business Program, including the
maintenance of separate lab notebooks and records (password-protected to the extent kept on a computer network) and separate personnel working on each of the activities under this CCPS Agreement and the activities covered under such Business Program

 10.5 Contract Manufacturers. Subject to the terms and conditions of this CCPS Agreement, either Party will have the
right to appoint by a written agreement “contract manufacturers”, meaning any Third Party or Affiliate of such Party that Manufactures Licensed Product (or components therefor, including for Bluebird, Vectors and associated Payloads) for
re-sale, but who itself is not a “Sublicensee” hereunder and thereby exercises “have made” rights granted by the other Party under Section 10.1 or Section 10.2, as applicable, as well as “contract research
organizations” and other providers performing services on a Party’s behalf, none of which will be deemed a “Sublicensee” hereunder. Such Party will be responsible for any such contract manufacturer, contract research organization
or service provider hereunder, and further will require any such contract manufacturer, contract research organization or service provider to agree in writing to comply with Sections 4.4 and 15. 

10.6 No Implied Rights. No license, sublicense or other right is or will be created or granted hereunder by implication, estoppel
or otherwise. Any licenses, sublicenses or rights will be granted only as expressly provided in this CCPS Agreement. Neither Party will practice or otherwise use any Licensed IP of the other Party other than in accordance with the licenses granted
in Section 10.1 and Section 10.2, as applicable. 
 10.7 Additional IP; Other In-Licenses. 

(a) Additional IP. Except as set forth in Section 10.7(b), Celgene may, on or after the CCPS Agreement Effective Date, elect
to include within the scope of the Bluebird Licensed IP any Know-How, Material, Patent, Regulatory Data, Regulatory Filings or Regulatory Approvals (“Additional Bluebird IP”), that would be Controlled by Bluebird but for required
payments of Additional Payments to a Third Party, by (i) providing notice to Bluebird of same and (ii) agreeing to pay and in fact paying all Additional Payments with respect to Celgene’s access or license to such Additional Bluebird
IP. Following Bluebird’s receipt of such notice and subject to Celgene’s performance of its obligations to pay any Additional Payments with respect to Celgene’s access or license to such Additional Bluebird IP, such Additional
Bluebird IP will be deemed Bluebird Licensed IP hereunder. For avoidance of doubt, this Section 10.7(a) does not apply to Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals licensed to Bluebird under the
Applicable Bluebird In-Licenses, all of which are deemed Controlled by Bluebird notwithstanding the terms of this Section 10.7(a). 

  
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AS AMENDED. 
  

 (b) Other In-Licenses. Celgene may, on or after the CCPS Agreement Effective
Date, elect to convert any Other In-License to an Applicable New In-License by providing notice to Bluebird of same. Upon Bluebird’s receipt of such notice, such Other In-License will be an Applicable New In-License hereunder, Appendix B
will automatically be updated to include such New In-License and the provisions of this CCPS Agreement applicable to New In-Licenses, including Section 11.1, will apply with respect to such Other In-License. 

10.8 Section 365(n) of the Bankruptcy Code. All rights and licenses granted pursuant to any section of this CCPS Agreement
are, and will be deemed to be, rights and licenses to “intellectual property” (as defined in Section 101(35A) of title 11 of the United States Code and of any similar provisions of applicable Laws under any other jurisdiction (the
“Bankruptcy Code”)). Each Party agrees that the other Party, as a licensee of rights and licenses under this CCPS Agreement, will retain and may fully exercise all of its rights and elections under the Bankruptcy Code. The Parties
further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under the Bankruptcy Code or analogous provisions of applicable Law outside the United States, the other Party will be entitled to a complete
duplicate of (or complete access to, as appropriate) any intellectual property licensed to it and all embodiments of such intellectual property, which, if not already in its possession, will be promptly delivered to it (a) upon any such
commencement of a bankruptcy proceeding upon such other Party’s written request therefor, unless the Party involved in the bankruptcy proceeding elects to continue to perform all of its obligations under this CCPS Agreement or (b) if not
delivered under clause (a), following the rejection of this CCPS Agreement by the Party in the bankruptcy proceeding upon written request therefor by the other Party. 
  

	11.	Payments and Royalties. 

 11.1 Payments for In-Licenses. 
 (a) United States. With respect to
the Development and Commercialization of Elected Candidate and Licensed Product for U.S. Administration hereunder, if any payments become due under any Applicable Pre-Existing In-License, Applicable New In-Licenses, Co-Co In-Licenses or Celgene
Licensed Product In-License during the CCPS Agreement Term, the contracting Party thereto will pay same and such payment will be treated as U.S. Development Expenses or Allowable Expenses, as appropriate, provided [***] 

(b) ROW. With respect to the Development and Commercialization of Elected Candidate and Licensed Product for ROW Administration
hereunder (including the Manufacture of Vectors and associated Payloads therefor pursuant to Section 7.4): 
 (i)
Applicable Pre-Existing In-Licenses. If any In-License Payment becomes due under any Applicable Pre-Existing In-License during the CCPS Agreement Term, Bluebird will pay same, provided that Celgene will reimburse Bluebird for any such
In-License Payment applicable to ROW Administration within thirty (30) days of Celgene’s receipt of Bluebird’s written invoice therefor, which In-License Payments (other than payments that are royalties) will not exceed [***],
and subject to Section 13.1. Any such reimbursement by Celgene to Bluebird (1) is in addition to and not in lieu of the other payments required by this Section 11 and (2) will not be subject to Section 11.3(d).

  
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AS AMENDED. 
  

 (ii) Applicable New In-Licenses. Celgene may elect to take a sublicense under
any New In-License of Bluebird or its Affiliates and upon such election, such New In-License will be an Applicable New In-License hereunder for all purposes. For the purposes of determining the Parties’ respective payment obligations, all
Applicable New In-Licenses as of and following the CCPS Agreement Effective Date will be listed on Appendix B. If any In-License Payment becomes due under any Applicable New In-License during the CCPS Agreement Term with respect to ROW
Administration, Bluebird will pay same and, subject to Section 13.1, Celgene will reimburse Bluebird for (i) [***] of such payment that are royalties, which royalties will be subject to Section 11.3(d), and (ii) [***] of such
payment that are not royalties, in each case ((i) and (ii)) within thirty (30) days of receipt of Bluebird’s written invoice therefor. If Celgene elects to convert an Other In-License to an Applicable In-License pursuant to
Section 10.7(b), Celgene will reimburse Bluebird for [***] of any In-License Payments that became due under such Applicable New In-License during the CCPS Agreement Term with respect to ROW Administration to the same extent as if such
Applicable New In-License was designated as such as of the CCPS Agreement Effective Date, including with respect to applicable Patent Costs in accordance with Section 6.1, provided that Bluebird provides Celgene with a reasonable accounting of
same. If any In-License Payments are royalties due under any Applicable New In-License during the CCPS Agreement Term with respect to Licensed Product for ROW Administration, such royalties will be subject to Section 11.3(d). To the extent that
any grant of a sublicense by Celgene or any Sublicensees under an Applicable New In-License triggers a payment obligation under such Applicable New In-License, Bluebird will pay same and Celgene will reimburse Bluebird for [***] of such payment
within thirty (30) days of receipt of Bluebird’s written invoice therefor. To the extent that any grant of a sublicense by Bluebird or any Sublicensees under a Celgene Licensed Product In-License triggers a payment obligation under such
Celgene Licensed Product In-License, Celgene will pay same and Bluebird will reimburse Celgene for [***] of such payment within thirty (30) days of receipt of Celgene’s written invoice therefor. 

(iii) If any payments become due under any Co-Co In-Licenses during the CCPS Agreement Term with respect to Licensed Product for ROW
Administration, the contracting Party will pay same, and further if Bluebird is the contracting Party, Celgene will reimburse Bluebird for such payment within thirty (30) days upon receipt of Bluebird’s written invoice therefor, subject to
Section 13.1. Any such reimbursement by Celgene to Bluebird (1) is in addition to and not in lieu of the other payments required by this Section 11 and (2) will not be subject to Section 11.3(d). If any payments are
royalties due under any Co-Co In-License during the CCPS Agreement Term with respect to Licensed Product for ROW Administration, such royalties will be subject to Section 11.3(d). 

(iv) If any payments become due under any Celgene Licensed Product In-License with respect to Licensed Product for ROW Administration,
Bluebird will be responsible for [***] of such payments as provided in Section 4.1(e) of the Master Collaboration Agreement, provided that if any such payments are royalties with respect to Licensed Product for ROW Administration, such
royalties will be subject to Section 11.3(d). 
 (c) [***] 

  
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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 11.2 Milestone Payments. 

(a) Generally. Celgene will make milestone payments (each, a “Milestone Payment”) to Bluebird upon the occurrence
of each of the milestones events (each, a “Milestone Event”) as set forth below in this Section 11.2. Each of the Milestone Payments will be payable to Bluebird by Celgene within forty-five (45) days of the
achievement of the specified Milestone Event, and such payments when owed or paid will be non-refundable and non-creditable, and not subject to set-off, except as otherwise set forth in Sections 4.3(c), 9.1(a), 9.1(b), 17.3(c) and 17.6 hereof or
Sections 4.1(e), 4.3 and 12.6 of the Master Collaboration Agreement. Except with respect to Modified Licensed Products, each of the Milestone Payments are payable only once in total under this CCPS Agreement, whether achieved by one or more Licensed
Products. Notwithstanding the foregoing, Bluebird will be entitled to receive [***] of the Milestone Payments below, other than the Milestone Payment for the first Milestone Event ([***]], for [***] for each new Modified Licensed Product.

 (b) Development Milestones. 
  

			
	 Milestone Event
	 	 Milestone Payment

	[***]	 	
		
	[***]	 	

 11.3 Royalties for Licensed Product for ROW Administration. 

(a) Rates. Subject to the remainder of this Section 11.3, Celgene will pay to Bluebird running royalties, on a Licensed
Product-by-Licensed Product basis, based on the total aggregate annual Net Sales by Selling Parties of such Licensed Product for ROW Administration in a given calendar year based on the Royalty Rate in the table set forth below. 

 

			
	 Annual Net Sales

of Each Licensed Product for ROW

Administration
	 	 Royalty Rate

	[***]	 	

 By way of example, in a given calendar year, if the aggregate annual Net Sales for a Licensed Product for ROW
Administration is [***] the following royalty payment would be payable for those Net Sales under this Section 11.3(a): [***] 
 The Parties
acknowledge and agree that for the purposes of calculating royalties under this Section 11.3(a), the country of sale for Licensed Product will be deemed to be the country in which such Licensed Product is administered to a patient. 

(b) Royalty Term. Royalties under Section 11.3(a) will be payable, on a Licensed Product-by-Licensed Product and
country-by-country basis, on the Net Sales of any Licensed Product for ROW Administration if at least one of the following two (2) conditions apply: 
 (i) if one or more Valid Claims within any of Patents included within the Bluebird Licensed IP Covers in such country such Licensed Product for ROW Administration; or 

(ii) [***] 

  
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AS AMENDED. 
  

 (c) Royalty Reduction. If Licensed Product is royalty-bearing only on account of
Section 11.3(b)(ii), then the royalty rates set forth in Section 11.3(a) with respect to Net Sales attributable to Licensed Product will be reduced by [***] 
 (d) Third Party Royalty Payments – ROW Administration. As provided in Section 11.1(b), if Celgene (or its Sublicensee) is required to pay to a Third Party under any New In-License or
Co-Co License or any Celgene Licensed Product In-License, any royalties for Commercialization of Licensed Product for ROW Administration, or if Celgene or its Sublicensee, in its reasonable judgment, is required to obtain a license from any Third
Party under any Patent Covering Licensed Product in order to Develop or Commercialize such Licensed Product for ROW Administration, and if Celgene (or its Sublicensee) is required to pay to such Third Party under such license any royalties, and the
infringement of such Patent cannot reasonably be avoided by Celgene or its Sublicensee, or if Celgene (or its Sublicensee) is required by a court of competent jurisdiction to pay royalties or lost profits to a Third Party based on a Patent as a
result of the such Commercialization (and the infringement of such Patent cannot reasonably be avoided by Celgene or its Sublicensee), then the amount of Celgene’s royalty obligations under this Section 11.3 will be reduced by [***] of the
amount of such royalties paid to such Third Party, provided however, that the royalties payable under Section 11.3(a) will not be reduced in any such event below [***] of the amounts set forth in Section 11.3(a) (but as may be further
reduced pursuant to Section 11.3(c) or 11.3(e)) for each royalty tier. Any royalties payable under any Applicable Pre-Existing In-Licenses may not be deducted under this Section 11.3(d) from royalties owed to Bluebird. Any royalties
payable under any Applicable New In-Licenses, Celgene Licensed Product In-Licenses and Co-Co Licenses may be deducted under this Section 11.3(d) from royalties owed to Bluebird. Celgene (or its Sublicensee) will use its commercially reasonable
efforts to minimize the amount of any of the foregoing payments owed to Third Parties. Prior to Celgene or its Sublicensee exercising its reasonable judgment under this Section 11.3(d), Celgene will provide Bluebird with written notice of a
potential need to obtain any license from Third Parties. The Parties will discuss the best course of action to resolve such potential license requirement(s). For clarity, the Parties acknowledge and agree that, notwithstanding anything in this CCPS
Agreement to the contrary, no royalties or other amounts payable by Celgene (or its Sublicensee) to a Third Party with respect to Licensed Product for U.S. Administration may act to reduce the amount of Celgene’s royalty obligations under this
Section 11.3. 
 (e) [***] 
 (f) Additional Royalty Provisions. The royalties payable under Section 11.3(a) will be subject to the following: 
 (i) only one royalty will be payable hereunder with respect to each Licensed Product unit; 
 (ii) royalties when owed or paid hereunder will, except as provided in Section 11.3(b), be non-refundable and non-creditable and not subject to set-off, except as otherwise provided in [***] 9.1(b),
17.3(d) and 17.6 hereof or Sections 4.1(e), 4.3 and 12.6 of the Master Collaboration Agreement; and 
 (iii) except as
expressly set forth in Section 11.3(c), Section 11.3(d) and Section 11.3(e), no other royalty deductions are permitted hereunder 

  
 28 

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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 11.4 Profit & Loss Share for Licensed Product for U.S.
Administration. The Parties will share in Operating Profit or Loss with respect to Licensed Product for U.S. Administration as follows: Bluebird will bear (and be entitled to) fifty percent (50%), and Celgene will bear (and be entitled
to) fifty percent (50%) (the “Profit & Loss Share”). Procedures for calendar quarterly reporting of actual results and review and discussion of potential discrepancies, quarterly reconciliation, reasonable forecasting,
and other finance and accounting matters, are set forth in Appendix F, and to the extent not set forth in Appendix F, will be established by the JGC, subject to Section 11.5(e). 

11.5 Payment Terms for Milestones and Royalties Due Hereunder. [***] 

11.6 Mutual Convenience of the Parties. The royalty and other payment obligations set forth hereunder have been agreed to by the
Parties for the purpose of reflecting and advancing their mutual convenience, including the ease of calculating and paying royalties and other amounts to Bluebird. 
  

	12.	 Ownership and Inventorship of IP.  

 12.1 Solely-Owned IP. Subject to Section 12.2, as between the Parties, each Party will own and retain all right, title and interest in and to any and all Know-How and Patents arising therefrom
that are discovered, created, conceived, developed or reduced to practice solely by or on behalf of such Party under or in connection with this CCPS Agreement, including as part of the Development & U.S. Commercialization Program
(“Solely Owned IP”). Subject to the licenses hereunder and the other terms and conditions of this CCPS Agreement, each Party will be solely responsible for the Prosecution and Maintenance, and the enforcement and defense, of any
Patents within its Solely Owned IP, and the other Party will have no rights with respect thereto. 
 12.2 Joint IP. The
Parties will jointly own any and all Know-How and Patents arising therefrom that are discovered, created, conceived, developed or reduced to practice jointly by or on behalf of the Parties under or in connection with this CCPS Agreement, including
as part of the Development & U.S. Commercialization Program (“Joint IP”). Each Party will have an undivided one-half interest in and to Joint IP. Each Party will exercise its ownership rights in and to such Joint IP,
including the right to license and sublicense or otherwise to exploit, transfer or encumber its ownership interest, without an accounting or obligation to, or consent required from, the other Party, but subject to the licenses hereunder and the
other terms and conditions of this CCPS Agreement, including Section 10.4. At the reasonable written request of a Party, the other Party will in writing grant such consents and confirm that no such accounting is required to effect the foregoing
regarding Joint IP. Each Party, for itself and on behalf of its Affiliates, licensees and sublicenses, and employees, subcontractors, consultants and agents of any of the foregoing, hereby assigns (and to the extent such assignment can only be made
in the future hereby agrees to assign), to the other Party a joint and undivided interest in and to all Joint IP. The Prosecution and Maintenance, and the enforcement and defense, of any Patents within Joint IP will be jointly managed by the Parties
on mutually agreeable terms to be entered into by the Parties at the time any such Patents are first filed, provided that (i) all recoveries and Patent Costs arising from the enforcement or defense of any Patents within Joint IP, absent further

  
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AS AMENDED. 
  

 
agreement, will be shared by the Parties in accordance with Section 14.2 (provided that sufficient advance written notice of any such Patent Costs is given to the Party not incurring same)
and (ii) Patent Costs incurred in connection with the Prosecution and Maintenance of Patents within Joint IP will be apportioned as set forth in Sections 13.1 and 13.3, provided that in each case ((i) and (ii)), and all recoveries and Patent
Costs arising from those activities, absent further agreement, will be shared equally by the Parties (provided that sufficient advance written notice of any such Patent Costs is given to the Party not incurring same), provided that if either Party
elects not to pay any such Patent Costs for any such Patent, the Parties will meet and agree upon an equitable way to treat such Patent. 
 12.3 Inventorship. Inventorship determination for all Patents worldwide arising from any Know-How discovered, created, conceived, developed or reduced to practice by or on behalf of the Parties
under or in connection with this CCPS Agreement and thus the ownership thereof will be made in accordance with applicable United States patent Laws. 
 12.4 Allocation. Notwithstanding Sections 12.1 – 12.3, the Patent Committee may allocate ownership of a particular item of intellectual property to improve the prospects of obtaining patent
protection with respect to such item of intellectual property, even if such allocation is not in accordance with the terms of Sections 12.1 – 12.3, so long as the Parties mutually agree to such allocation. 

 

	13.	Patent Prosecution and Maintenance. 

 13.1 Generally. Subject to Sections 13.2 and 13.3, each Party will have the sole right to Prosecute and Maintain Patents within its respective Licensed IP. Bluebird will use commercially reasonable
efforts to, where applicable and permitted under applicable Law and upon Celgene’s reasonable request, separate parent Patent applications within the Bluebird Licensed IP into one or more separate Patent applications for Specific Patents, where
doing so would not reasonably be expected to materially harm any Patent within the Bluebird Licensed IP or other Patents owned by Bluebird or its Affiliates, provided that the foregoing limitation will not apply to Bluebird Licensed IP that is
Collaboration IP. [***] 
 13.2 Input. Each Party will regularly provide the other with copies of all applications for
Patents within its respective Licensed IP, and all other material submissions and correspondence with any patent authorities regarding such Patents, in sufficient time to allow for review and comment by the other Party. In addition, each Party will
provide the other Party and its counsel with an opportunity to consult with such Party and its counsel regarding Prosecution and Maintenance of any such Patents within the Field, and such Party will consider in good faith all such comments timely
made by such other Party and its counsel. In the event of any disagreement between the Parties, the licensor Party will have the final decision-making authority with respect to the matter involved as long as the licensor Party acts in good faith.

 13.3 Specific Patents. For any Patent within the Bluebird Licensed IP [***] (each “Specific
Patent”), the following will apply: upon Celgene’s written request, and provided that Bluebird reasonably agrees with Celgene that the following Prosecution and Maintenance activities would not materially harm any other Patent within
the Bluebird Licensed IP or other Patents owned by Bluebird or its Affiliates (other than Collaboration IP), Celgene will control the Prosecution and Maintenance of the Specific Patents, and notwithstanding anything in

  
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AS AMENDED. 
  

 
Section 13.1 to the contrary, Celgene will be solely responsible for the payment of all related Patent Costs. In addition, Celgene will provide Bluebird and its counsel with an opportunity
to consult with Celgene and its counsel regarding Prosecution and Maintenance of any such Specific Patents, and Celgene will include or reflect all reasonable comments timely made by Bluebird and its counsel. Celgene acknowledges and agrees that
Bluebird may grant similar rights to other exclusive Third Party licensees under any Patent within the Bluebird Licensed IP that has claims Covering only a product that is not a Licensed Product (or its manufacture or use) and no other product (or
its manufacture or use), other than Specific Patents. If the Parties cannot agree whether or not any Patent within the Bluebird Licensed IP is a Specific Patent, or if Bluebird claims that the foregoing Prosecution and Maintenance activities would
materially harm any other Patent within the Bluebird Licensed IP or other Patents owned by Bluebird or any of its Affiliates, either of the Parties may refer such dispute to a mutually agreeable, disinterested, conflict-of-interest-free individual
not affiliated or consulting with either Party and who has at least fifteen (15) years of patent prosecution experience in the pharmaceutical field. Any such arbitration will be conducted under the then-current rules of the American Arbitration
Association, and the decision of the arbitrator will be final. 
 13.4 Election Not to Prosecute or
Maintain or Pay Patent Costs. If a Party elects not (i) to Prosecute or Maintain any Patents within its respective Licensed IP in any particular country before the applicable filing deadline or continue such activities once filed in a
particular country, or (ii) to pay the Patent Costs associated with Prosecution or Maintenance of any Patents within the Licensed IP as required by Section 13.1, then in each such case such first Party will so notify the other Party,
promptly in writing and in good time to enable any deadlines by which an action must be taken to preserve such Patent in such country to be met. Upon receipt of each such notice by such first Party, such other Party will have the right, but not the
obligation, to notify such first Party in writing on a timely basis that such other Party will continue the Prosecution or Maintenance of such Patent on terms the Parties shall mutually agree; it being understood that only U.S. Patents controlled by
Celgene will be subject to this sentence. Notwithstanding the foregoing, upon receipt of each such notice by Bluebird, Celgene will have the right, but not the obligation, to notify Bluebird in writing on a timely basis that Celgene will assume
control of the Prosecution or Maintenance of such Patent within the Bluebird Licensed IP, and bear the Patent Costs thereafter incurred by Celgene with respect thereto. In addition, Celgene will provide Bluebird and its counsel with an opportunity
to consult with Celgene and its counsel regarding Prosecution and Maintenance of any such Patents, and Celgene will include or reflect all reasonable comments timely made by Bluebird and its counsel. If after making such election, Celgene elects not
to pay the Patent Costs associated with Prosecution or Maintenance of any such Patent, then in each such case Celgene will so notify Bluebird and on the ninetieth (90th) day after Bluebird’s receipt of such notice such Patent will no longer be licensed to Celgene hereunder and
will no longer be included within the “Bluebird Licensed IP” hereunder. 
 13.5 Third Party Rights. To the
extent that a Third Party licensor of a Party has retained any right to Prosecute or Maintain any Patent within such Party’s Licensed IP licensed to the other Party hereunder, or otherwise be involved in such activities, such Party will use
commercially reasonable efforts to cause such Third Party licensor to take the actions specified by this Section 13 (including Sections 13.6 and 13.7) in a manner consistent with the in-license applicable thereto, but such Party will not be
deemed to be in breach of its obligations under this Section 13 if, after using such commercially reasonable efforts, it is unable to comply with such obligations because of actions taken or not taken by such Third Party licensor. 

  
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AS AMENDED. 
  

 13.6 Patent Extensions. Subject to the remainder of this Section 13.6, if
any election for patent term restoration or extension, supplemental protection certificate or any of their equivalents may be made with respect to any Patent within the Licensed IP, after consultation through the JGC. If the Parties are not able to
reach mutual agreement, (i) Celgene will have the sole right to make the final decision whether or not to seek such patent term restoration or extension, supplemental protection certificate or any of their equivalents with respect to Specific
Patents and Patents within the Collaboration IP licensed to Celgene hereunder and the Celgene Licensed IP, and (ii) Bluebird will have the sole right to make the final decision whether or not to seek such patent term restoration or extension,
supplemental protection certificate or any of their equivalents with respect to all other Patents within the Bluebird Licensed IP. 
 13.7 Regulatory Exclusivity Periods. With respect to any Patent listings required for any Regulatory Exclusivity Periods for Product, the Parties will mutually agree on which Patents within the
Licensed IP to list, provided that if the Parties are not able to agree, Celgene will have the right to make the final decision, and provided further that the exercise of such right by Celgene will not increase or otherwise change the rights or
obligations of the Parties hereunder. 
 13.8 Cooperation. Each Party will reasonably cooperate with the other Party in
the Prosecution and Maintenance of Patents within the Licensed IP. Such cooperation includes promptly executing all documents, or requiring inventors, subcontractors, employees and consultants and agents of such Party and its Affiliates and
Sublicensees to execute all documents, as reasonable and appropriate so as to enable the Prosecution and Maintenance of any such Patents in any country. 
 13.9 Patent Marking. For Licensed Product for U.S. Administration, the JGC will determine the Patent marking requirements in accordance with applicable Law. For Licensed Product for ROW
Administration, Celgene will mark, and will cause all other Selling Parties to mark, Product with all Patents within the Bluebird Licensed IP in accordance with applicable Law, which marking obligation will continue for as long as (and only for as
long as) required under applicable Law. 
 13.10 Common Interest Disclosures. With regard to any information or opinions
disclosed pursuant to this CCPS Agreement by one Party to the other Party regarding Prosecution and Maintenance of Patent within the Licensed IP, or enforcement of intellectual property and/or technology by or against Third Parties, Bluebird and
Celgene agree that they have a common legal interest in determining the ownership, scope, validity and/or enforcement of the Licensed IP, and whether, and to what extent, Third Party intellectual property rights may affect the conduct of the
Development and Commercialization of any Licensed Product, and have a further common legal interest in defending against any actual or prospective Third Party claims based on allegations of misuse or infringement of intellectual property rights
relating to the Development or Commercialization of any Licensed Product. Accordingly, the Parties agree that all such information and materials obtained by the Parties from each other will be used solely for purposes of the Parties’ common
legal interests with respect to the conduct of the Agreement. All such information and materials will be treated as protected by the attorney-client privilege, 

  
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AS AMENDED. 
  

 
the work product privilege, and any other privilege or immunity that may otherwise be applicable. By sharing any such information and materials, neither Party intends to waive or limit any
privilege or immunity that may apply to the shared information and materials. Neither Party will have the authority to waive any privilege or immunity on behalf of the other Party without such other Party’s prior written consent, nor will the
waiver of privilege or immunity resulting from the conduct of one Party be deemed to apply against any other Party. This Section 13.10 will be subject to any right granted by either Party to any Third Party, provided that the grant of such
right to such Third Party does not conflict with the other Party’s rights or the first Party’s obligations under this CCPS Agreement. 
  

	14.	Patent Enforcement and Defense. 

 14.1 Notice. Each Party will promptly notify, in writing, the other Party upon learning of any actual or suspected Competitive Infringement of any Patents within the Licensed IP by a Third Party,
or of any claim of invalidity, unenforceability, or non-infringement of any Patents within the Licensed IP, and will, along with such notice, supply the other Party with any evidence in its possession pertaining thereto. For purposes of this CCPS
Agreement, “Competitive Infringement” means any allegedly infringing activity in the Field (which, for the purposes of this definition, will include all indications and will not be limited to cancer) with respect to a Patent
within the Licensed IP, which activity (i) falls within the scope then in effect of the licenses granted by Bluebird to Celgene as set forth in Sections 10.1 and 10.2, (ii) is subject to Section 14.2(f), or (iii) would
be competitive with a Licensed Product and targets the same Target Antigen as such Licensed Product. 
 14.2 Enforcement and
Defense. [***] 
  

	15.	Confidentiality.  

The Parties acknowledge and agree that terms of this CCPS Agreement and all Materials, ideas and information of any kind, whether in
written, oral, graphical, machine-readable or other form, whether or not marked as confidential or proprietary, which are transferred, disclosed or made available by a Party or at the request of a Party, including any of the foregoing of Third
Parties, will be subject to the provisions of Section 10 of the Master Collaboration Agreement. The Parties agree to issue the joint press release on Appendix G promptly following the CCPS Agreement Effective Date. A redacted
version of this CCPS Agreement is attached hereto as Appendix M. 
  

	16.	Warranties; Limitations of Liability; Indemnification. 

 16.1 Representations and Warranties. Each Party represents and warrants to the other as of the CCPS Agreement Effective Date that it has the legal right and power to enter into this CCPS Agreement,
to extend the rights and licenses granted or to be granted to the other in this CCPS Agreement, and to fully perform its obligations hereunder. 

  
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AS AMENDED. 
  

 16.2 Additional Representations and Warranties of Bluebird. Except as set forth
in Schedule 16.2, Bluebird represents and warrants to Celgene that, as of the CCPS Agreement Effective Date: 
 (a)
Licensed IP. Appendix H sets forth a complete and accurate list of all Patents included in the Bluebird Licensed IP, indicating the owner, licensor and/or co-owner(s), if applicable, and, for any Elected Candidate and Licensed
Product-relevant subject matter or Materials, if no Patent is specifically licensed, a list of all subject matter or Materials that are included in the Bluebird Licensed IP, including those licensed under a materials use license or equivalent.
Bluebird Controls the Patents listed on Appendix H and the Know-How within the Bluebird Licensed IP, and is entitled to grant the licenses specified herein. Bluebird has not granted to any Third Party any rights or licenses under such Patents
or Know-How within the Bluebird Licensed IP that would conflict with the licenses granted to Celgene hereunder. 
 (b) Third
Party Agreements. The Applicable Bluebird In-Licenses are valid and binding obligations of Bluebird and, to the Knowledge of Bluebird, the applicable licensor, enforceable against Bluebird and, to the Knowledge of Bluebird, the applicable
licensor, in accordance with their terms, except as may be limited by general principles of equity (regardless of whether considered in a proceeding at law or in equity) and by applicable bankruptcy, insolvency, moratorium and other similar Laws of
general application relating to or affecting creditors’ rights generally. Neither Bluebird nor any of its Affiliates has received any notice of any counterparty’s intention to terminate any Applicable Bluebird In-License in whole or in
part or any notice requesting any amendment, alteration or modification of such Applicable Bluebird In-License or any sublicense or assignment thereunder. There is no breach or default, or event which upon notice or the passage of time, or both,
would give rise to any breach or default, in the performance of any Applicable Bluebird In-License by Bluebird or any of its Affiliates or, to the Knowledge of Bluebird, the counterparty thereto, and Bluebird has not received any notice of any such
breach, default or event. Except for the Applicable Bluebird In-Licenses, neither Bluebird nor any of its Affiliates is a party to any license, sublicense or other agreement pursuant to which Bluebird or such Affiliate has received a license or
other rights relating to the Elected Candidate or Licensed Product. All Patents and Know-How licensed to Bluebird under the Applicable Bluebird In-Licenses are Controlled by Bluebird for purposes of the licenses granted to Celgene under this CCPS
Agreement. 
 (c) Patents. To Bluebird’s Knowledge, the Patents listed on Appendix H have been procured or
are being procured from the respective patent offices in accordance with applicable Law. None of the Patents included in the Bluebird Licensed IP is or has been involved in any opposition, cancellation, interference, reissue or reexamination
proceeding, and no Bluebird Licensed IP is the subject of any judicial, administrative or arbitral order, award, decree, injunction, lawsuit, proceeding or stipulation. Neither Bluebird nor any of its Affiliates has received any notice alleging that
the Patents in the Bluebird Licensed IP are invalid or unenforceable, or challenging Bluebird’s ownership of or right to use any such rights. 
 (d) No Conflicts. The execution, delivery and performance by Bluebird of this CCPS Agreement and the consummation of the transactions contemplated hereby will not result in any violation of,
conflict with, result in a breach of or constitute a default under any understanding, contract or agreement to which Bluebird is a party or by which it is bound. Neither Bluebird nor any of its Affiliates has entered into any agreement or otherwise
licensed, granted, assigned, transferred, conveyed or otherwise encumbered or disposed of any right, title or interest in or to any of its assets, including any intellectual property rights, that would in any way conflict with or impair the scope of
any rights or licenses granted to Celgene hereunder. 

  
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AS AMENDED. 
  

 (e) Outlicenses. Appendix J sets forth a complete and accurate list of all
agreements relating to the licensing, sublicensing or other granting of rights by Bluebird to any Person with respect to the Bluebird Licensed IP and the Field, and Bluebird has provided complete and accurate copies of all such agreements to
Celgene. Except for the Applicable Bluebird In-Licenses, Bluebird and its Affiliates are not subject to any payment obligations to Third Parties as a result of the execution or performance of this CCPS Agreement. Neither Bluebird nor any of its
Affiliates has granted any liens or security interests on the Bluebird Licensed IP and the Bluebird Licensed IP is free and clear of any mortgage, pledge, claim, security interest, covenant, easement, encumbrance, lien or charge of any kind.

 (f) No Proceedings. There is no action, suit, proceeding or investigation pending or, to the Knowledge of Bluebird,
currently threatened in writing against or affecting Bluebird that questions the validity of this CCPS Agreement or the right of Bluebird to enter into this CCPS Agreement or consummate the transactions contemplated hereby. 

(g) No Infringement. Neither Bluebird nor any of its Affiliates has received any notice of any claim that any Patent, Know-How or
other intellectual property Controlled by a Third Party would be infringed or misappropriated by the production, use, research, Development, Manufacture or Commercialization of the Elected Candidate or Licensed Product pursuant to this CCPS
Agreement, and, to the Knowledge of Bluebird, there are no Patents, Know-How or other intellectual property owned by a Third Party and not included in the Bluebird Licensed IP or Bluebird In-Licensed IP that are necessary for the production, use,
research, Development, Manufacture or Commercialization of Elected Candidate or Licensed Product. 
 16.3 Disclaimers.
Without limiting the respective rights and obligations of the Parties expressly set forth herein, each Party specifically disclaims any guarantee that any Licensed Product will be successful, in whole or in part. EXCEPT AS OTHERWISE EXPRESSLY
PROVIDED IN THIS CCPS AGREEMENT, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, WITH RESPECT TO ANY PATENTS, KNOW-HOW, ELECTED CANDIDATE OR LICENSED PRODUCT, INCLUDING WARRANTIES OF VALIDITY OR
ENFORCEABILITY OF ANY PATENT RIGHTS, TITLE, QUALITY, MERCHANTABILITY, FITNESS FOR A PARTICULAR USE OR PURPOSE, PERFORMANCE, AND NONINFRINGEMENT OF ANY THIRD PARTY PATENTS OR OTHER INTELLECTUAL PROPERTY RIGHTS. 

16.4 [***] 

16.5 Performance by Others. The Parties recognize that each Party may perform some or all of its obligations under this CCPS
Agreement through Affiliates and permitted subcontractors provided, however, that each Party will remain responsible and liable for the performance by its Affiliates and permitted subcontractors and will cause its Affiliates and permitted
subcontractors to comply with the provisions of this CCPS Agreement in connection therewith. 

  
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AS AMENDED. 
  

 16.6 Indemnification. 

(a) Indemnification by Celgene. Celgene will indemnify Bluebird, its Affiliates and their respective directors, officers,
employees, Third Party licensors and agents, and their respective successors, heirs and assigns (collectively, “Bluebird Indemnitees”), and defend and save each of them harmless, from and against any and all losses, damages,
liabilities, costs and expenses (including reasonable attorneys’ fees and expenses) (collectively, “Losses”) in connection with any and all suits, investigations, claims or demands of Third Parties (collectively, “Third
Party Claims”) against the Bluebird Indemnitees arising from or occurring as a result of: (i) the material breach by Celgene of any term of this CCPS Agreement; (ii) any gross negligence or willful misconduct on the part of
Celgene in performing its obligations under this CCPS Agreement; (iii) the Development or Commercialization by or on behalf of Celgene or any of its Affiliates or Sublicensees of Elected Candidate or Licensed Product for ROW Administration, and
(iv) [***] except in each case for those Losses for which Bluebird has an obligation to indemnify Celgene pursuant to Section 11.6(b), as to which Losses each Party will indemnify the other to the extent of their respective liability;
provided, however, that Celgene will not be obligated to indemnify Bluebird Indemnitees for any Losses to the extent that such Losses arise as a result of gross negligence or willful misconduct on the part of an Bluebird Indemnitee. 

(b) Indemnification by Bluebird. Bluebird will indemnify Celgene, its Affiliates and their respective directors, officers,
employees and agents, and their respective successors, heirs and assigns (collectively, “Celgene Indemnitees”), and defend and save each of them harmless, from and against any and all Losses in connection with any and all Third
Party Claims against the Celgene Indemnitees arising from or occurring as a result of: (i) the material breach by Bluebird of any term of this CCPS Agreement; (ii) any gross negligence or willful misconduct on the part of Bluebird in
performing its obligations under this CCPS Agreement; or (iii) the Development by or on behalf of Bluebird or any of its Affiliates or Sublicensees of Elected Candidate or Licensed Product, except in each case for those Losses for which Celgene
has an obligation to indemnify Bluebird pursuant to Section 11.6(a), as to which Losses each Party will indemnify the other to the extent of their respective liability for the Losses; provided, however, that Bluebird will not be obligated to
indemnify Celgene Indemnitees for any Losses to the extent that such Losses arise as a result of gross negligence or willful misconduct on the part of a Celgene Indemnitee. 
 (c) Notice of Claim. All indemnification claims provided for in Sections 11.6(a) and 11.6(b) will be made solely by such Party to this CCPS Agreement (the “Indemnified Party”). The
Indemnified Party will promptly notify the indemnifying Party (an “Indemnification Claim Notice”) of any Losses or the discovery of any fact upon which the Indemnified Party intends to base a request for indemnification under
Section 11.6(a) and 11.6(b), but in no event will the indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification Claim Notice must contain a description of the claim and the nature and
estimated amount of such Loss (to the extent that the nature and amount of such Loss is known at such time). The Indemnified Party will furnish promptly to the indemnifying Party copies of all papers and official documents received in respect of any
Losses and Third Party Claims. 
 (d) Defense, Settlement, Cooperation and Expenses. 

(i) Control of Defense. At its option, the indemnifying Party may assume the defense of any Third Party Claim by giving written
notice to the Indemnified Party within thirty 

  
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AS AMENDED. 
  

 
(30) days after the indemnifying Party’s receipt of an Indemnification Claim Notice, provided however that (A) the Third Party Claim solely seeks monetary damages and (B) the
indemnifying Party expressly agrees in writing that as between the indemnifying Party and the Indemnified Party, the indemnifying Party will be solely obligated to satisfy and discharge the Third Party Claim in full and is able to reasonably
demonstrate that it has sufficient financial resources (the matters described in (A) and (B), the “Litigation Conditions”). The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed as
an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor will it constitute a waiver by the indemnifying Party of any defenses it may assert against the Indemnified
Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party (the
indemnifying Party will consult with the Indemnified Party with respect to a possible conflict of interest of such counsel retained by the indemnifying Party). The Indemnified Party may, at any time, assume the defense of a Third Party Claim if at
any time the Litigation Conditions are not satisfied with respect to such Claim. In the event the indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party will immediately deliver to the indemnifying Party all original
notices and documents (including court papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the defense of a Third Party Claim, except as provided in Section 11.6(d)(ii) the
indemnifying Party will not be liable to the Indemnified Party for any legal costs or expenses subsequently incurred by such Indemnified Party in connection with the analysis, defense or settlement of the Third Party Claim. In the event that it is
ultimately determined that the indemnifying Party is not obligated to indemnify, defend or hold harmless the Indemnified Party from and against the Third Party Claim, the Indemnified Party will reimburse the indemnifying Party for any and all costs
and expenses (including attorneys’ fees and costs of suit) and any Third Party Claims incurred by the indemnifying Party in its defense of the Third Party Claim. 
 (ii) Right to Participate in Defense. Without limiting Section 11.6(d)(i), any Indemnified Party will be entitled to participate in, but not control, the defense of such Third Party Claim and
to employ counsel of its choice for such purpose; provided, however, that such employment will be at the Indemnified Party’s own cost and expense unless (i) the employment thereof has been specifically authorized by the indemnifying Party
in writing, (ii) the indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 11.6(d)(i) (in which case the Indemnified Party will control the defense), (iii) the interests of the Indemnified
Party and the indemnifying Party with respect to such Third Party Claim are sufficiently adverse to prohibit the representation by the same counsel of both Parties under applicable Law, ethical rules or equitable principles, or (iv) the
indemnifying Party no longer satisfies the Litigation Conditions, in which case the indemnifying Party will assume [***] percent ([***]%) of any such costs and expenses of counsel for the Indemnified Party. 

(iii) Settlement. With respect to any Third Party Claims that relate solely to the payment of money damages in connection with a
Third Party Claim and that will not result in the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified Party in any manner, and as to which the indemnifying Party
will have acknowledged in writing the obligation to indemnify the Indemnified Party 

  
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AS AMENDED. 
  

 
hereunder, and subject to the Litigation Conditions being satisfied, the indemnifying Party will have the sole right to agree to the entry of any judgment, enter into any settlement or otherwise
dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, will deem appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has assumed the defense of the Third
Party Claim in accordance with Section 11.6(d)(i), the indemnifying Party will have authority to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss provided it obtains the prior written consent of
the Indemnified Party (such consent not to be unreasonably withheld, delayed or conditioned). The indemnifying Party will not be liable for any settlement or other disposition of a Loss by an Indemnified Party that is reached without the prior
written consent of the indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party will admit any liability with respect to or settle, compromise or discharge, any Third
Party Claim without the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld, delayed or conditioned. 
 (iv) Cooperation. If the indemnifying Party chooses to defend or prosecute any Third Party Claim, the Indemnified Party will, and will cause each other Indemnified Party to, cooperate in the
defense or prosecution thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and appeals as may be reasonably requested in connection therewith.
Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that are reasonably relevant to such Third Party Claim, and making
Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the indemnifying Party will reimburse the Indemnified Party for all
its reasonable out-of-pocket costs and expenses in connection therewith. 
 (v) Costs and Expenses. Except as provided
above in this Section 11.6(d), the costs and expenses, including attorneys’ fees and expenses, incurred by the Indemnified Party in connection with any claim will be reimbursed on a calendar quarter basis by the indemnifying Party, without
prejudice to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party.

 16.7 Insurance. Each Party will maintain at its sole cost and expense, an adequate liability insurance or
self-insurance program (including product liability insurance) to protect against potential liabilities and risk arising out of activities to be performed under this CCPS Agreement, and any agreement related hereto and upon such terms (including
coverages, deductible limits and self-insured retentions) as are customary in the U.S. pharmaceutical industry for the activities to be conducted by such Party under this CCPS Agreement. Subject to the preceding sentence, such liability insurance or
self-insurance program will insure against all types of liability, including personal injury, physical injury or property damage arising out of the manufacture, sale, use, distribution or marketing of Licensed Product. The coverage limits set forth
herein will not create any limitation on a Party’s liability to the other under this CCPS Agreement. 

  
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AS AMENDED. 
  

 16.8 U.S. Administration Liabilities. In the event that either Party
(i) incurs any Losses in connection with a Third Party Claim for personal injury or death caused by the use of Licensed Product for U.S. Administration, or (ii) is required to make payments to any Third Party in order to acquire a license
or other rights under Patents or Know-How necessary for the Development, Manufacture or Commercialization of Licensed Product for U.S. Administration (collectively, “U.S. Administration Liabilities”), such U.S. Administrative Losses
arising from or occurring as a result of the performance, in good faith, of the Development, Manufacture or Commercialization of Licensed Product for U.S. Administration in accordance with this CCPS Agreement will be charged to such Party’s
Operating Profit or Loss under the Profit & Loss Share, provided that Operating Profit or Loss will not include U.S. Administration Liabilities of a Party or its Affiliates: (1) that are caused by a breach of this CCPS Agreement by
such Party or its Affiliates; (2) incurred with respect to or allocable to products other than Licensed Product for U.S. Administration; or (3) that are subject to indemnification by such Party pursuant to Section 16.6 (and for
clarity, if a Third Party makes a Third Party Claim directly against Bluebird (or any of its Affiliates) or Celgene (or any of its Affiliates), respectively, that would otherwise be indemnified by Bluebird or Celgene, respectively, if such Third
Party Claim had been made against the other Party (or any of its Affiliates), then U.S. Administration Liabilities incurred by Bluebird or Celgene in connection with such direct Third Party Claim will not be included in the calculation of Operating
Profit or Loss). 
  

	17.	Term and Termination. 

 17.1 Term. This CCPS Agreement will commence as of the CCPS Agreement Effective Date and, unless sooner terminated in accordance with the terms hereof or by mutual written consent, will continue on
a country-by-country basis, until there are no more payments owed one or the other Party on Licensed Product in such country (the longest such period of time for any Licensed Product hereunder, the “CCPS Agreement Term”); for
clarity, unless sooner terminated in accordance with the terms hereof or by mutual written consent, this CCPS Agreement Term will continue in all events until Licensed Product is no longer being Developed or Commercialized in the United States. Upon
there being no more such payments hereunder for any such Licensed Product in such country (other than the United States), the licenses contained in Section 10.1 will become fully paid up and will remain exclusive with respect to such Licensed
Product in such country. 
 17.2 Termination by Bluebird. 

(a) Breach. Bluebird will have the right to terminate this CCPS Agreement in full upon delivery of written notice to Celgene in the
event of any material breach by Celgene of any terms and conditions of this CCPS Agreement in a manner that fundamentally frustrates the transactions contemplated by this CCPS Agreement, provided that such termination will not be effective if such
breach, has been cured within [***] after written notice thereof is given by Bluebird to Celgene specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] after such notice if Celgene commences actions to
cure such default within such [***] and thereafter diligently continues such actions, but fails to cure the default by the end of such [***]); provided, however, that to the extent such material breach involves the failure to make a payment when
due, such breach must be cured within [***] after written notice thereof is given by Bluebird to Celgene. 

  
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AS AMENDED. 
  

 (b) [***] 
 (c) Termination of the Profit & Loss Share. Bluebird will have the right to terminate the Profit & Loss Share by delivering written notice to Celgene, such termination to be
effective [***] following the date of such notice. Promptly following such notice, the Parties will enter into a license agreement with respect to the United States and the ROW, which agreement will be substantially identical to the License
Agreement attached as Exhibit A to the Master Collaboration Agreement, with such changes that the Parties may, acting reasonably, mutually agree are required in order to address any specific facts or circumstances existing at the time of such
termination. The Parties will enter into such license agreement no later than the effective date of such termination and, if such license agreement is not entered into prior the expiration of such [***], upon execution, the effective date of such
license agreement will be deemed to be the effective date of such termination. For clarity, (i) termination of the Profit & Loss Share pursuant to this Section 17.2(c) will not release Bluebird from any obligation or liability
which, at the time of the effective date of such termination, has already accrued to Celgene or which is attributable to a period prior to the effective date of such termination, and (ii) any events that have already occurred before the
effective date of such termination (such as achievement of any milestones) will not trigger any payment obligation by Celgene to Bluebird under such executed license agreement (other than, for clarity, the Milestone Payment based on the Pivotal
Study if not already paid or accrued under this CCPS Agreement). 
 17.3 Termination by Celgene. 

(a) Breach. Celgene will have the right to terminate this CCPS Agreement in full upon delivery of written notice to Bluebird in the
event of any material breach by Bluebird of any terms and conditions of this CCPS Agreement in a manner that fundamentally frustrates the transactions contemplated by this CCPS Agreement, provided that such termination will not be effective if such
breach has been cured within [***] after written notice thereof is given by Celgene to Bluebird specifying the nature of the alleged breach (or, if such default cannot be cured within such [***] period, within [***] after such notice if Bluebird
commences actions to cure such default within such [***] period and thereafter diligently continues such actions, but fails to cure the default by the end of such [***]). 
 (b) Discretionary Termination. Beginning with [***], Celgene will have the right to terminate this CCPS Agreement in full, at its discretion for any reason, by delivering written notice to
Bluebird, such termination to be effective [***] following the date of such notice. 
 (c) [***] 

(d) Alternative to Termination Under Section 17.3(a). If Celgene has the right to terminate this CCPS Agreement under
Section 17.3(a) or 17.3(c) (including expiration of all applicable cure periods thereunder), in lieu of exercising such termination right, Celgene may elect once by written notice to Bluebird before the end of such applicable cure period to
have this CCPS Agreement continue in full force and effect and instead have, starting immediately after the end of such applicable cure period, any future Milestone Payments set forth in Section 11.2(b) and the royalty rates set forth in the
table set forth in Section 11.3(a) be reduced by [***], provided that such reduction will not apply if such future Milestone Payments and royalty rates have already been reduced pursuant to Section 11.4(c) of the Master Collaboration
Agreement. 

  
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AS AMENDED. 
  

 17.4 Effects of Termination or Expiration. Upon termination (but not expiration
pursuant to Section 17.1) of this CCPS Agreement for any reason: 
 (a) Wind Down. Celgene will responsibly
wind-down, in accordance with accepted pharmaceutical industry norms and ethical practices, any on-going clinical studies for which it has responsibility hereunder in which patient dosing has commenced or, if reasonably practicable and requested by
Bluebird, allow Celgene, its Affiliates or its Sublicensees to complete such trials. Celgene will be responsible for any costs associated with such wind-down. Bluebird will pay all costs incurred by either Party to complete such studies should
Bluebird request that such studies be completed. 
 (b) Sublicenses. A termination of this CCPS Agreement will not
automatically terminate any sublicense granted by Celgene pursuant to Section 10.3 for Commercialization rights with respect to a non-Affiliated Sublicensee, provided that (i) such Sublicensee is not then (a) in material breach of any
provision of this CCPS Agreement or (b) in material breach of the applicable sublicense agreement or otherwise in breach of such sublicense agreement in a manner that would give rise to a right of termination on the part of Celgene,
(ii) if Bluebird terminates this CCPS Agreement pursuant to Section 17.2(a) for Celgene’s failure to fulfill its payment obligations hereunder, such Sublicensee agrees to and does pay to Bluebird all outstanding amounts that accrued
as a result of such Sublicensee’s activities under the sublicense, (iii) Bluebird will have the right to step into the role of Celgene as sublicensor under any such sublicense executed after the CCPS Agreement Effective Date, with all the
rights that Celgene had under such sublicense, solely with respect to the Bluebird Licensed IP, prior to termination of this CCPS Agreement (including the right to receive any payments to Celgene by such Sublicensee that accrue from and after the
date of the termination of this CCPS Agreement solely with respect to the Bluebird Licensed IP), (iv) such Sublicensee will pay to Bluebird all amounts that Celgene would have been obligated to pay to Bluebird hereunder with respect to such
Sublicensee’s activities had this CCPS Agreement not terminated (less any amounts received by Bluebird in clause (iii) above) and (v) the survival of such sublicense will not result in an imposition of any additional obligations on
the part of Bluebird that are not included within the scope of this CCPS Agreement. Celgene will include in any sublicense agreement executed after the CCPS Agreement Effective Date that relates solely to the Bluebird Licensed IP a provision in
which said Sublicensee acknowledges its obligations to Bluebird under this Section 17.4(b). 
 (c) Cessation of
Rights. Except as otherwise expressly provided in this Section 17, all rights and licenses granted by Bluebird to Celgene in Section 10.1 will terminate, and all rights granted by Celgene to Bluebird in Section 10.2 will
terminate, and Celgene and its Affiliates and Sublicensees will cease all use of Bluebird Licensed IP and all Development and Commercialization of Elected Candidate and Licensed Product. 

(d) Regulatory Approvals. To the extent permitted by applicable Law, and subject to Bluebird paying commercially reasonable
compensation to Celgene for the assets to be transferred pursuant to this Section 17.4(d) (such compensation to either be mutually agreed to or determined through arbitration as provided in Section 17.4(h) below, and such compensation to

  
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AS AMENDED. 
  

 
be reduced by [***] from what would be commercially reasonable compensation if this CCPS Agreement is terminated by Bluebird pursuant to Section 17.2(a)), all Regulatory Approvals and other
regulatory filings and communications owned (in whole or in part) or otherwise Controlled by Celgene and its Affiliates and Sublicensees solely relating to the Elected Candidate and/or Licensed Product, and all other documents solely relating to and
necessary to further Develop and Commercialize Elected Candidate and Licensed Product, as such items exist as of the effective date of such termination (including all solely related completed and ongoing clinical studies) will be assigned to
Bluebird, and Celgene will provide to Bluebird one (1) copy of the foregoing and all documents contained in or referenced in any such items, together with the raw and summarized data for any clinical studies (and where reasonably available,
electronic copies thereof). In the event of failure to obtain assignment, subject to the Parties agreeing on commercially reasonable compensation for the right to access and reference, Celgene hereby consents and grants to Bluebird the right to
access and reference (without any further action required on the part of Celgene, whose authorization to file this consent with any Regulatory Authority is hereby granted) any such item. 

(e) Licenses. Subject to Bluebird paying (i) commercially reasonable compensation to Celgene for the licenses to be granted
pursuant to subsection (1) of this Section 17.4(e) (such compensation to either be mutually agreed to or determined through arbitration as provided in Section 17.4(h) below, and such compensation to be reduced by [***] from what would
be commercially reasonable compensation if this CCPS Agreement is terminated by Bluebird pursuant to Section 17.2(a)), and (ii) amounts payable to Celgene’s licensors as set forth below, Celgene will grant to Bluebird and its
Affiliates (1) a worldwide, perpetual and irrevocable, nontransferable (except in connection with a permitted assignment of this CCPS Agreement in accordance with Section 18.12), exclusive license, with the right to grant sublicenses
through multiple tiers (subject to Section 10.3, mutatis mutandis), under Celgene Licensed Product IP, and (2) an exclusive sublicense under the Celgene Licensed Product In-Licensed IP, in each case ((1) and (2)) to the extent
such Celgene Licensed Product IP and Celgene Licensed Product In-Licensed IP are used in or Cover the Licensed Product as of the effective date of termination and to the extent such Celgene Licensed Product IP and Celgene Licensed Product
In-Licensed IP exist as of the effective date of such termination (including in each case any additions, divisions, continuations, continuations-in-part, invention certificates, substitutions, reissues, reexaminations, extensions, registrations,
supplementary protection certificates and renewals of such Celgene Licensed Product IP and Celgene Licensed Product In-Licensed IP), solely to the extent necessary to research, Develop, Manufacture and Commercialize the Elected Candidate and
Licensed Product. With respect to grants of a sublicense under subsection (2) above, Bluebird will be responsible for all amounts payable to the applicable licensor that are attributable to Bluebird as a sublicensee thereunder under this CCPS
Agreement, and Celgene will pay same and Bluebird will reimburse Celgene for [***] percent ([***]%) of such payments within thirty (30) days of receipt of Celgene’s written invoice therefor. Celgene will provide Bluebird with copies of all
applicable Celgene Licensed Product In-Licenses promptly following the effective date of the termination of this License Agreement. The Prosecution and Maintenance and enforcement and defense rights and obligations of the Parties with respect to any
Patents licensed or sublicensed to Bluebird pursuant to this Section 17.4(e) will be discussed and agreed to by the Parties, with the understanding that such Prosecution and Maintenance and

  
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AS AMENDED. 
  

 
enforcement and defense rights and obligations will be substantially similar to those set forth in Section 13, with the roles of Bluebird and Celgene reversed (and such other changes as are
appropriate from the context, and taking into account any rights retained by a Third Party licensor of Celgene to Prosecute and Maintain or enforce and defend any Patent sublicensed to Bluebird under this Section 17.4(e)). 

(f) Trademarks. Subject to Bluebird paying commercially reasonable compensation to Celgene for the license to be granted pursuant
to this Section 17.4(f) (such compensation to either be mutually agreed to or determined through arbitration as provided in Section 17.4(h) below, and such compensation to be reduced by [***] from what would be commercially reasonable
compensation if this CCPS Agreement is terminated by Bluebird pursuant to Section 17.2(a)), Celgene will exclusively license to Bluebird any registered or unregistered trademarks or internet domain names that are specific to and solely used for
the Licensed Product worldwide (it being understood that the foregoing will not include any trademarks or internet domain names that contain the corporate or business name(s) of Celgene). 

(g) Baylor Product License. If the Licensed Product is subject to a Baylor Product License, then Celgene will, at Bluebird’s
written request, assign to Bluebird the applicable Baylor Product License in accordance with the terms of Section 13.5 thereof, provided that if such Baylor Product License applies to other products, Celgene will assign or sublicense to
Bluebird that portion of the Baylor Product License that applies to the Licensed Product, and with the consequences therein stated (that is, Celgene will remain responsible for all payments accruing thereunder before the assignment, and Bluebird
will be responsible for all payments accruing thereunder after such assignment). 
 (h) Commercially Reasonable
Compensation. If the Parties are unable to agree on the amount of commercially reasonable compensation payable by Bluebird to Celgene pursuant to Sections 17.4(d), 17.4(e) or 17.4(f) within ten (10) days of the effective date of termination
of this CCPS Agreement, [***] 
 (i) Country Termination. If this CCPS Agreement is terminated only with respect to a
specific country pursuant to Section 11.2(b) or Section 11.3(c), the provisions of this Section 17.4 will apply only with respect to such terminated country. 
 17.5 Survival. In addition to the termination consequences set forth in Section 17.4, the following provisions will survive termination or expiration of this CCPS Agreement: Sections 1,
4.3, 8.2, 2.3(c)(ii), 10.3(c) (mutatis mutandis with respect to licenses granted to Bluebird under Section 17.4, but excluding subsections (i) and (ii) of Section 10.3(c)) 10.6, 10.8, 11.5, 11.6, 12, 15, 16.3, 16.4, 16.6,
16.7, 16.8, 17.4, 17.5, 17.6 and 18, and Appendix F (to the extent required to provide for a true up of Operating Profit and Losses during the term of this CCPS Agreement following termination of this CCPS Agreement). Termination or
expiration of this CCPS Agreement will not relieve the Parties of any liability or obligation which accrued hereunder prior to the effective date of such termination or expiration nor preclude either Party from pursuing all rights and remedies it
may have hereunder or at law or in equity with respect to any breach of this CCPS Agreement nor prejudice either Party’s right to obtain performance of any obligation. All other rights and obligations will terminate upon expiration of this CCPS
Agreement. 

  
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AS AMENDED. 
  

 17.6 Right to Set-off. Notwithstanding anything to the contrary in this CCPS
Agreement, each Party has the right at all times to retain and set off against all amounts due and owing to the other Party as determined in a final judgment any damages recovered by such Party for any Losses incurred by such Party. 

 

	18.	General Provisions. 

18.1 Cumulative Remedies and Irreparable Harm. All rights and remedies of the Parties hereunder will be cumulative and in addition
to all other rights and remedies provided hereunder or available by agreement, at law or otherwise. Each Party acknowledges and agrees that breach of any of the terms or conditions of this CCPS Agreement would cause irreparable harm and damage to
the other and that such damage may not be ascertainable in money damages and that as a result thereof the non-breaching Party would be entitled to seek from a court equitable or injunctive relief restraining any breach or future violation of the
terms contained herein by the breaching Party without the necessity of proving actual damages or posting bond. Such right to equitable relief is in addition to whatever remedies either Party may be entitled to as a matter of law or equity, including
money damages. 
 18.2 Business Combination and IP. 

(a) Bluebird Business Combination. Notwithstanding anything to the contrary herein, for purposes of this CCPS Agreement, no
Know-How, Materials, Patents, Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Bluebird or any of its Affiliates prior to a Business Combination of Bluebird will be Controlled for purposes of this CCPS Agreement after
such Business Combination of Bluebird, other than (i) Applicable Bluebird In-Licenses to the extent in effect immediately prior to such Business Combination of Bluebird, (ii) Collaboration IP, and (iii) any Patent that claims
priority, directly or indirectly, to any other Patent first Controlled before such Business Combination of Bluebird will be Controlled thereafter no matter when such Patent is filed or issued. 

(b) Celgene Business Combination. Notwithstanding anything to the contrary herein, for purposes of this CCPS Agreement, no
Know-How, Materials, Patents Regulatory Data, Regulatory Filings or Regulatory Approvals not Controlled by Celgene or any of its Affiliates prior to a Business Combination of Celgene will be Controlled for purposes of this CCPS Agreement after such
Business Combination of Celgene, other than Collaboration IP, and except that any Patent that claims priority, directly or indirectly, to any other Patent first Controlled before such Business Combination of Celgene will be Controlled thereafter no
matter when such Patent is filed or issued. 
 18.3 Relationship of Parties. Nothing in this CCPS Agreement is intended
or will be deemed to constitute a partnership, agency, employer-employee or joint venture relationship between the Parties. No Party will incur any debts or make any commitments for the other, except to the extent, if at all, specifically provided
therein. There are no express or implied Third Party beneficiaries hereunder (except as set forth in Section 10.2 and except for Bluebird Indemnitees and Celgene Indemnitees for purposes of Section 16.6). 

18.4 Compliance with Law. Each Party will perform or cause to be performed any and all of its obligations or the exercise of any
and all of its rights hereunder in good scientific manner 

  
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AS AMENDED. 
  

 
and in compliance with all applicable Law. Without limiting the foregoing, Bluebird will comply with comply with all applicable Laws and regulations (including U.S. Foreign Corrupt Practices Act
and any other applicable anti-bribery or anti-kickback laws or regulations). 
 18.5 Force Majeure. Neither Party will be
liable to the other for failure of or delay in performing obligations set forth in this CCPS Agreement (other than any obligation to pay monies when due), and neither will be deemed in breach of such obligations, if such failure or delay is due to
natural disasters or any causes reasonably beyond the control of such Party; provided that the Party affected will promptly notify the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any such
causes and to resume performance of its obligations as soon as possible. 
 18.6 Governing Law. This CCPS Agreement will
be governed by and construed in accordance with the Laws of the State of New York, without respect to its conflict of laws rules, provided that any dispute relating to the scope, validity, enforceability or infringement of any Patents or Know-How
will be governed by, and construed and enforced in accordance with, the substantive laws of the jurisdiction in which such Patents or Know-How apply. 
 18.7 Counterparts; Facsimiles. This CCPS Agreement may be executed in one or more counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the
same instrument. Facsimile or PDF execution and delivery of this CCPS Agreement by either Party will constitute a legal, valid and binding execution and delivery of this CCPS Agreement by such Party 

18.8 Headings. All headings in this CCPS Agreement are for convenience only and will not affect the meaning of any provision
hereof. 
 18.9 Waiver of Rule of Construction. Each Party has had the opportunity to consult with counsel in connection
with the review, drafting and negotiation of this CCPS Agreement. Accordingly, the rule of construction that any ambiguity in this CCPS Agreement will be construed against the drafting Party will not apply. 

18.10 Interpretation. Whenever any provision of this CCPS Agreement uses the term “including” (or “includes”),
such term will be deemed to mean “including without limitation” (or “includes without limitations”). “Herein,” “hereby,” “hereunder,” “hereof” and other equivalent words refer to this CCPS
Agreement as an entirety and not solely to the particular portion of this CCPS Agreement in which any such word is used. All definitions set forth herein will be deemed applicable whether the words defined are used herein in the singular or the
plural. Unless otherwise provided, all references to Sections and Appendices in this CCPS Agreement are to Sections and Appendices of this CCPS Agreement. References to any Sections include Sections and subsections that are part of the related
Section (e.g., a section numbered “Section 2.1” would be part of “Section 2”, and references to “Section 2.1” would also refer to material contained in the subsection described as “Section 2.1(a)”).

 18.11 Binding Effect. This CCPS Agreement will inure to the benefit of and be binding upon the Parties, their
Affiliates, and their respective lawful successors and assigns. 
 18.12 Assignment. This CCPS Agreement may not be
assigned by either Party, nor may either Party delegate its obligations or otherwise transfer licenses or other rights created by this 

  
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AS AMENDED. 
  

 
CCPS Agreement, except as expressly permitted hereunder or otherwise without the prior written consent of the other Party, which consent will not be unreasonably withheld, delayed or conditioned;
provided that without consent (i) Celgene may assign this CCPS Agreement to (x) an Affiliate or (y) its successor in connection with the merger, consolidation, or sale of all or substantially all of its assets, and (ii) Bluebird
may assign this CCPS Agreement to (x) an Affiliate or (y) its successor in connection with the merger, consolidation, or sale of all or substantially all of its assets or that portion of its business pertaining to the subject matter of
this CCPS Agreement; provided further that, except in the case where a Party is involved in a merger or consolidation where it is the surviving entity and no assets of such Party that are subject to this CCPS Agreement have been transferred as a
result of such merger or consolidation, (a) such assigning Party provides the other Party to this Agreement with at least thirty (30) business days advance written notice of such assignment(s) and the assigning Party agrees in a written
agreement delivered prior to such assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to remain fully liable for the performance of its obligations under this Agreement by its assignee(s), (b) the
assignee(s) agree in a written agreement delivered prior to such assignment(s) to the non-assigning Party (and upon which such non-assigning Party may rely) to assume performance of all such assigned obligations, (c) in the case of any
assignment(s) by Bluebird, all Bluebird Licensed IP licensed to Celgene under this CCPS Agreement will be transferred to such assignee(s) effective as of such assignment(s), (d) all of the matters referred to in clauses (a), (b) and (c),
as applicable, will be set forth in documentation reasonably acceptable to the non-assigning Party prior to any such assignment(s) (and with such reasonable acceptance not to be unreasonably withheld, conditioned or delayed) and in all cases will
provide the non-assigning Party with the full benefits of its rights under this Agreement (after taking into account all risks involving applicable counter-party performance and bankruptcy and insolvency risks, including those involving contractual
rejection under 11 USC §365) as if no such assignment(s) had occurred, and (e) in the case of any assignment(s), the assigning Party will reimburse the non-assigning Party for all of the legal fees and expenses incurred by such
non-assigning Party in connection with the matters set forth in clause (D) of this sentence in an aggregate amount not to exceed [***], and provided, further, that if Bluebird wishes to assign any Bluebird Licensed IP to its Affiliates, it will
be permitted to do so conditioned on each such Affiliate becoming a party to this CCPS Agreement, in the form of an amendment to this CCPS Agreement executed by Celgene, Bluebird and such Affiliate, pursuant to which such Affiliate would agree to
assume all obligations hereunder, and grant to Celgene all rights hereunder, with respect to the Bluebird Licensed IP. The terms of this Agreement will be binding upon and will inure to the benefit of the successors, heirs, administrators and
permitted assigns of the Parties. Any purported assignment in violation of this Section 18.12 will be null and void ab initio. 
 18.13 Notices. All notices, requests, demands and other communications required or permitted to be given pursuant to this CCPS Agreement will be in writing and will be deemed to have been duly
given upon the date of receipt if delivered by hand, recognized international overnight courier, confirmed facsimile transmission, or registered or certified mail, return receipt requested, postage prepaid to the applicable address or facsimile
number in Section 13.14 in the Master Collaboration Agreement. Either Party may change its designated address and facsimile number by notice to the other Party in the manner provided in this Section 13.14. 

  
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AS AMENDED. 
  

 18.14 Amendment and Waiver. This CCPS Agreement may be amended, supplemented, or
otherwise modified only by means of a written instrument signed by both Parties; provided that any unilateral undertaking or waiver made by one Party in favor of the other will be enforceable if undertaken in a writing signed by the Party to be
charged with the undertaking or waiver. Any waiver of any rights or failure to act in a specific instance will relate only to such instance and will not be construed as an agreement to waive any rights or fail to act in any other instance, whether
or not similar. 
 18.15 Severability. In the event that any provision of this CCPS Agreement will, for any reason, be
held to be invalid or unenforceable in any respect, such invalidity or unenforceability will not affect any other provision hereof, and the Parties will negotiate in good faith to modify this CCPS Agreement to preserve (to the extent possible) their
original intent. 
 18.16 Entire Agreement. This CCPS Agreement, together with the Master Collaboration Agreement, is the
sole agreement with respect to the subject matter and supersedes all other agreements and understandings between the Parties with respect to same (including Confidential Agreement). In the event of any conflict between the terms of this CCPS
Agreement and the terms of the Master Collaboration Agreement, the terms of this CCPS Agreement will control. 
 18.17 Force
Majeure. Neither Celgene nor Bluebird will be liable for failure of or delay in performing obligations set forth in this CCPS Agreement (other than any obligation to pay monies when due), and neither will be deemed in breach of such obligations,
if such failure or delay is due to natural disasters or any causes reasonably beyond the control of Celgene or Bluebird and without the fault or negligence of the Party so failing or delaying; provided that the Party affected will promptly notify
the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any such causes and to resume performance of its obligations as soon as possible. 

[Remainder of this Page Intentionally Left Blank] 

  
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AS AMENDED. 
  

 IN WITNESS WHEREOF, the Parties have caused this Co-Development, Co-Promote and Profit
Share Agreement to be executed by their respective duly authorized officers as of the CCPS Agreement Effective Date. 
  

			
	BLUEBIRD BIO, INC.
		
	By:	 	  

		 	(Signature)
		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

	
	CELGENE CORPORATION
		
	By:	 	  

		 	(Signature)
		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

  
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AS AMENDED. 
  

 Appendix A 

Additional Defined Terms 
 “Elected Candidate”1 means the Optioned Candidate selected by Celgene under the Master Collaboration Agreement that specifically targets the following Target Antigen:
[                    ]. 
  

 

	1 	 To be updated by the Parties to specifically identify the candidate that is the subject of the option election.

  

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 Appendix B 

Applicable New In-Licenses 

  

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 Appendix C 

Applicable Pre-Existing In-Licenses 

  

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 Appendix D 

Certain Manufacturing Definitions 
 [***] 

  

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 Appendix E 

Co-Co In-Licenses 

  

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 Appendix F 

Profit & Loss Share 
 [***] 

  

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 Appendix G 

Press Release 

  

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AS AMENDED. 
  

 Appendix H 

Certain Patents within the Licensed IP Controlled 
 by Bluebird as of the CCPS Agreement Effective Date 

  

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 [***] 

  

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 Appendix J 

Bluebird Agreements 

  

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 Appendix K 

[***] 

  

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 Appendix L 

[***] 

  

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AS AMENDED. 
  

 Appendix M 

Redacted Version of CCPS Agreement 

  

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AS AMENDED. 
  

 Schedule 4.3(b) 

Cost Allocation 
 [***]

  

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AS AMENDED. 
  

 Schedule 5.6 

Minimum BlueBird Sales Representative Qualifications 

 

	 	•	 	 BS in Business or Science; 5+ years sales experience in pharmaceutical/biotechnology industry with at least two years of related hematology/oncology
sales strongly preferred (or proven success in medical field). 

  

	 	•	 	 May not be debarred or disqualified by the FDA (or subject to a similar sanction by any Regulatory Authority outside the United States), or the subject
of an FDA debarment or disqualification investigation or proceeding (or similar proceeding by any Regulatory Authority outside the United States), or convicted, indicted or charged with any crime that would constitute grounds for FDA debarment or
disqualification (or similar sanctions by any Regulatory Authority outside the United States). 

  

	 	•	 	 Proven track record that demonstrates top sales accomplishments. 

 

	 	•	 	 Demonstrated ability to understand and communicate technical clinical material clearly and effectively. 

 

	 	•	 	 Demonstrated ability to develop critical relationships with physicians, nurses and ancillary staff within academic hospitals, clinics, and private
practice facilities. 

  

	 	•	 	 Demonstrated understanding of oncology therapeutic area, products and marketplace. 

 

	 	•	 	 Demonstrated knowledge of healthcare system processes including reimbursement. 

  

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AS AMENDED. 
  

 Schedule 16.2 

Exceptions to Bluebird’s Representations and Warranties in Section 16.2 

  

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 [***] 

  

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 [***] 

  

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 [***] 

  

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AS AMENDED. 
  

 Exhibit F 
 Additional Celgene Option Information 
 Celgene will provide to Bluebird, along with the
Option Exercise Notice: 
  

	 	•	 	 The clinical Development plan and commercial launch plan that Celgene is contemplating to achieve Regulatory Approval for such Optioned Candidate,
together with the cost estimates for such a clinical program; 

  

	 	•	 	 The U.S. Development Budget, which for purposes of this Exhibit F will be for the first twelve (12) months of the Co-Development,
Co-Promote and Profit Share Agreement. Celgene may update such U.S. Development Budget within ten (10) business days of first providing the same; and 

 

	 	•	 	 Such other supporting information related to the items listed in the foregoing bullet points as Bluebird may reasonably request, to the extent such
information is in Celgene’s possession (for clarity, without any obligation to create or generate new information.) 

  

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AS AMENDED. 
  

 [***] 

  

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AS AMENDED. 
  

 Exhibit H 
 Redacted Master Collaboration Agreement 

  

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AS AMENDED. 
  

 Exhibit I 
 Press Release 
 bluebird bio Announces Global Strategic Collaboration
with Celgene to Advance Gene Therapy in Oncology 
 - Separately, Celgene and bluebird bio to collaborate with the Center
for Cell and Gene Therapy to advance new and existing CAR T cell programs 
 CAMBRIDGE, Mass.—March XX, 2013 — bluebird bio, a
privately-held biotechnology company focused on gene therapy, today announced the formation of a broad, global strategic collaboration with Celgene Corporation to discover, develop and commercialize novel disease-altering gene therapies in oncology.
The collaboration will focus on applying gene therapy technology to genetically modify a patient’s own T-cells, known as chimeric antigen receptor (CAR) T-cells, to target and destroy cancer cells. The multi-year research and development
collaboration has the potential to lead to the development and commercialization of multiple CAR T-cell products. Celgene has an option to license any products resulting from the collaboration after the completion of a Phase 1 clinical study for
each such product. bluebird will be responsible for research and development activity through Phase 1 studies. 
 Simultaneous with this
announcement, Celgene and bluebird bio also announced a related strategic collaboration in the CAR T-cell field with the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children’s Hospital and The Methodist Hospital,
Houston led by Malcolm Brenner, M.D., Ph.D., professor, Department of Molecular and Human Genetics and the director, Center for Cell and Gene Therapy. bluebird bio, Celgene and Dr. Brenner’s team will work collaboratively to advance and
develop existing and new products and programs in the CAR T cell field. 
 “The genetic manipulation of autologous T cells is a new
frontier in oncology, one that shows early promise in emerging clinical trials,” said Tom Daniel, President, Research & Early Development at Celgene. “We see strong prospects for this collaboration between Celgene, bluebird bio
and Baylor College of Medicine’s experienced leaders in this emerging field, led by Dr. Brenner, to advance this innovative approach to intractable problems in oncology.”
 “We believe that our recent advances in the industrialization of our gene therapy platform will drive improvements in the potency, purity, efficiency and scalability of our lentiviral gene therapy
programs. These advances provide us with an opportunity to apply our platform, intellectual property and know-how to the development of additional product candidates in indications such as CAR T-cells for cancer,” stated Jeff Walsh, chief
operating officer of bluebird bio. “Celgene is a global leader in oncology and, combined with Baylor’s expertise in the CAR T-cell field, we have created a great opportunity to drive innovation in a new and exciting area.” 

Financial terms of the agreement include a substantial upfront payment and up to $225 million per product in potential option fees and clinical and
regulatory milestones. bluebird bio also has the right to participate in the development and commercialization of any licensed products resulting from the collaboration through a 50/50 co-development and profit share in the United States in exchange
for a reduction of milestones. Royalties would also be paid in regions where there is no profit share including in the United States if bluebird declines to exercise their co-development and profit sharing rights. 

  

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AS AMENDED. 
  

 The gene therapy products currently in clinical development at bluebird bio for the treatment of
childhood cerebral adrenoleukodystrophy, beta-thalassemia and sickle cell disease are independent of this collaboration. 
 Cowen and Company
contributed as a strategic advisor to bluebird bio on this transaction. 
 About CAR T-Cell Therapy 

CAR T-cell therapy represents a promising, emerging approach to treating cancer. Blood is withdrawn from a patient and the T-cells are then extracted from
a patient’s blood. These cells are then genetically modified to recognize and attack cancer cells and then re-introduced into the patient’s blood. The patient’s genetically modified cells are intended to bind to and kill the target
cancer cells. 
 About bluebird bio 
 bluebird bio is developing potentially transformative gene therapies for severe genetic and orphan diseases. bluebird bio has two clinical-stage programs in development for childhood cerebral
adrenoleukodystrophy (CCALD) and beta-thalassemia/sickle cell disease. Led by a management team with extensive industry experience, bluebird bio is privately held and backed by top-tier life sciences investors. Its operations are located in
Cambridge, Mass., San Francisco and Paris, France. For more information, please visit www.bluebirdbio.com. 
 About Celgene 

Celgene Corporation, headquartered in Summit, New Jersey, is an integrated global biopharmaceutical company engaged primarily in the discovery,
development and commercialization of novel therapies for the treatment of cancer and inflammatory diseases through gene and protein regulation. For more information, please visit www.celgene.com. 

  

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AS AMENDED. 
  

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AS AMENDED. 
  

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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 Exhibit L 
 Call Option 
  

	1.	Call Option. 

  

	1.1	Notice. In the event that, during the Call Option Period, a Call Option Triggering Event occurs, then Bluebird will give Celgene written notice of such Call
Option Triggering Event (a “Call Option Triggering Event Notice”). In the event that such Call Option Triggering Event occurring during the Call Option Period is a Bluebird Call Option Triggering Event, Bluebird will not
commence a process intended to result in (or does result in) a Corporate Event until after delivery of the Call Option Triggering Event Notice to Celgene. For purposes of this Exhibit L, the “Call Option Period” means the period, if
any, beginning on the date of termination of provisions set forth in Section 6.1 through 6.8 of the Agreement and, unless earlier terminated pursuant to Section 1.11 below, ending on the earliest to occur of: (i) expiration of the
Initial Collaboration Term, unless Celgene has elected to extend the Initial Collaboration for the First Collaboration Program Extension pursuant to Section 2.1(d), and (ii) expiration of the First Collaboration Program Extension if
Celgene has elected to extend the Initial Collaboration for the First Collaboration Program Extension pursuant to Section 2.1(d), even if Celgene has elected to extend the Collaboration Term for Second Collaboration Term Extension;
provided that the Parties understand and agree that if the Call Option Period would otherwise terminate prior to the expiration of the applicable Call Option Exercise Period (as such Call Option Exercise Period may be extended by
Bluebird from time to time) then the Call Option Period shall automatically be extended such that it shall expire on the same day as the expiration of the applicable Call Option Exercise Period (as such Call Option Exercise Period may be extended by
Bluebird from time to time). 

  

	1.2	 Exercise; Diligence Process. Celgene shall have the right, but not the obligation, to exercise the Call Option by delivery of written notice to
Bluebird (the “Call Option Exercise Notice”) at any time prior to the expiration of the Call Option Exercise Period. Upon request made by Celgene during the Call Option Exercise Period, Bluebird will use its commercially reasonable
efforts to provide Celgene with reasonable access to such scientific, technical, clinical, manufacturing, regulatory and other information and such personnel, at reasonable times and on a reasonable number of occasions, as may be reasonably
necessary for Celgene to determine its own internal estimate of the Call Option Exercise Price. For clarity, Bluebird shall be under no obligation to share with Celgene its own internal estimate of the Call Option Exercise Price, if any. If Celgene
fails to exercise the Call Option by delivery of written notice to Bluebird or otherwise delivers written notice to Bluebird of its decision not to exercise the Call Option, in either case, prior to the expiration of the Call Option Exercise Period,
then (a) the procedures specified in Section 1.6 below will automatically terminate 

  

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AS AMENDED. 
  

	 	
without any obligation on either Party to consummate the Call Option and (b) Bluebird shall be free to consummate a Corporate Event without any further obligation to Celgene under this
Exhibit L, provided that, if a Corporate Event is not publicly announced within nine (9) months following the Call Option Triggering Event Notice described above, then, if during the remaining portion of the Call Option Period, a
subsequent Call Option Triggering Event occurs, the procedures set forth in this Exhibit L will apply with respect to such subsequent Call Option Triggering Event. 

 

	1.3	Payment. If the Call Option has been exercised as of the expiration of the Call Option Exercise Period, then, effective as of the expiration of the Call Option
Exercise Period, Celgene will be required to pay Bluebird at the Call Option Closing (defined below) an amount in cash equal to the Call Option Exercise Price determined in accordance with the procedures specified in Section 1.6 below which
Call Option Exercise Price will be binding on both Parties (unless otherwise mutually agreed in accordance with Section 1.6(i)), subject only to the conditions and exceptions specified in Section 1.4 and Section 1.10 below. Subject to
satisfaction of the conditions and exceptions specified in Section 1.4 and Section 1.10 below and final determination of the Call Option Exercise Price, Celgene will make such payment, and Bluebird will consummate the matters it is
contemplated by this Exhibit L to perform on the date of such payment, all on the later of (a) the date of consummation of the applicable Corporate Event involving Bluebird (the “Other Closing”), and (b) ten
(10) business days advance written notice by Bluebird to Celgene of such Other Closing (such later date, the “Call Option Closing”). 

  

	1.4	 Government Approvals. The Call Option Closing and all payment obligations of Celgene set forth in Section 1.3 shall be conditioned upon
Receipt of Regulatory Approvals. As used herein, “Receipt of Regulatory Approvals” means that all regulatory approvals required to consummate the transactions contemplated by the Call Option Closing shall have been obtained and
shall remain in full force and effect through the Call Option Closing and all statutory waiting periods applicable to the Call Option Closing shall have expired or been terminated. Except for any Non-Required Remedy (defined below), each of Celgene
and Bluebird shall use its commercially reasonable good faith efforts to obtain all requisite consents of any court or government authority regarding the exercise of the Call Option, including, if required by federal or state antitrust authorities,
promptly taking all steps to secure government antitrust clearance, including cooperating in good faith with any government investigation including the prompt production of documents and information demanded by a second request for documents and of
witnesses if requested, to the same extent and in the same manner (including with respect to the payment by Celgene of all fees required to be paid to any government authority in connection with any HSR Filing) as provided in Section 5.9 of
this Agreement with respect to any proposed Development & Commercialization Agreement, mutatis mutandis. In the event that the Parties make an HSR Filing under this Section 1.4, then the Call Option shall terminate (i) at
the election of either Party, immediately upon notice to the other Party, in the event that the United States of America Federal Trade Commission or the United States of America Department of Justice obtains a preliminary injunction under the HSR
Act against the Parties to enjoin the 

  

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AS AMENDED. 
  

	 	
transactions contemplated by this Exhibit L, or (ii) at the election of either Party, immediately upon written notice to the other Party, in the event that either the Call Option HSR
Clearance Date or the Receipt of Regulatory Approvals shall not have occurred on or prior to one hundred twenty (120) days after the effective date of the HSR Filing (including expiration or termination of the applicable waiting period under
the HSR Act or the inability to eliminate any Non-Required Remedy as part of any consent or approval). Notwithstanding anything to the contrary in this Agreement, in connection with the obligations contained in this Exhibit L, neither Party nor any
of its respective Affiliates shall be required to sell, divest, hold separate, license or agree to any other structural or conduct remedy with respect to, any operations, divisions, businesses, product lines, customers, assets or relationships of
such Party or any of its respective Affiliates (any such action, a “Non-Required Remedy”). 

  

	1.5	Fully Paid-Up, Non-Terminable Exclusive Licenses; Expense Reimbursement. Upon effectiveness of the Call Option Closing, the Parties covenant and agree that the
following shall apply: 

  

	 	a.	This Agreement will terminate, provided that the provisions of Sections 12.4(a) and 12.4(c) will not apply with respect to such termination. 

 

	 	b.	 On the six-month anniversary of the Call Option Closing, each Co-Development, Co-Promote and Profit Share Agreement in effect at the time of the Call
Option Closing will terminate (provided that, notwithstanding the foregoing, neither Party shall be responsible for any Profit & Loss Share payments that would otherwise have accrued from and after the Call Option Closing, the JGC and all
subcommittees shall terminate as of the Call Option Closing and Celgene shall have sole discretion to make (and refrain from making) all decisions of the JGC and all subcommittees as of such date, and Bluebird shall have no further rights or
obligations with respect to the performance of Development or Commercialization activities under the U.S. Development Plan or Worldwide Commercialization Plan), and, effective upon such termination, the Parties will enter into a License Agreement in
the form attached hereto as Exhibit A with respect to the Optioned Candidate that was the subject of such Co-Development, Co-Promote and Profit Share Agreement, provided that (i) no royalties will be payable under
Section 4.3 of the License Agreement and no Milestone Payments will be payable under Section 4.2 of the License Agreement, (ii) with respect to any In-License Payment that becomes due from and after the Call Option Closing, Celgene
will reimburse Bluebird for one hundred percent (100%) of such payments within thirty (30) days of receipt of Bluebird’s written invoice therefor, (iii) all recovery-sharing provisions in Section 5.2 and Section 7.2
shall terminate, other than with respect to the provisions of Section 7.2(e) regarding reimbursement of Bluebird, and any other Third Party licensees of Bluebird, on a pro rata basis for each of their out-of-pocket costs and expenses
incurred as a result of cooperating with Celgene as reasonably requested by Celgene in connection with the action (provided that, for clarity, the rest of the provisions in Section 5.2 and Section 7.2 shall remain in full force and effect,
including Bluebird’s right to 

  

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AS AMENDED. 
  

	 	
indemnification and reimbursement of Patent Costs if joined as a party to any action controlled by Celgene under Section 7.2), (iv) all of the licenses granted to Celgene to Licensed IP
thereunder will become fully-paid up other than as set forth in subjection (ii) above, (v) all of the licenses granted to Celgene to Licensed IP thereunder will become perpetual and non-terminable other than with respect Bluebird
In-Licensed IP if, as a result of a breach by Celgene of its obligations under Section 2.8(c), the applicable Third Party licensor has the right to terminate an Applicable Bluebird In-License pursuant to which such Bluebird In-Licensed IP is
licensed to Bluebird, (vi) all obligations of Celgene to commercialize any product will terminate, (vii) neither Celgene nor its Affiliates shall be subject to the exclusivity provision contained in Section 3.4, provided that if
Celgene or its Affiliates are no longer pursuing the Development or Commercialization of the applicable Licensed Product (including any reasonable periods of customary delay), then the exclusivity provision contained in Section 3.4 shall no
longer apply to Bluebird and its Affiliates (and Celgene will provide notice of same to Bluebird upon Bluebird’s written request), and after such time Celgene will not have any enforcement rights under clause (viii) below with respect to
activities under clause (iii) of such “Competitive Infringement” definition, (viii) Celgene will have the exclusive right to institute and prosecute all enforcement claims under Section 7.2 with respect to “Competitive
Infringement” (as defined in Section 7.1) for which Celgene has the first right to institute such claims (provided that, for clarity, the rest of the provisions in Section 7.2 shall remain in full force and effect, including
Bluebird’s right to participate and be involved in any action controlled by Celgene under Section 7.2, but not a secondary right for Bluebird to institute any such enforcement claim with respect to Competitive Infringement), (ix) the
technology transfer obligations under Section 2.3 of the License Agreement will include, but not be limited to, the obligation to transfer to Celgene complete and fully annotated Vector maps and sequences, including details of Payloads and any
and all nucleic acid constructs, plasmids, cell lines and associated methodologies and production protocols, and (x) such License Agreement will be appropriately tailored to reflect the above. For clarity, and notwithstanding anything to the
contrary herein, no license to Bluebird In-Licensed IP under any License Agreement described in this Section 1.5(b) shall be deemed to be fully-paid up, it being understood and agreed that in no event shall Celgene be relieved of any obligation
to reimburse Bluebird for any In-License Payment within thirty (30) days of receipt of Bluebird’s written invoice therefor or any obligation to provide Bluebird with written reports pursuant to Section 4.4 in order to confirm any such
required payments. 

  

	 	c.	 The Parties will amend each License Agreement to provide that (i) no royalties will be payable under Section 4.3 of the License Agreement and
no Milestone Payments will be payable under Section 4.2 of the License Agreement, (ii) with respect to any In-License Payment that becomes due from and after the Call Option Closing, Celgene will reimburse Bluebird for one hundred percent
(100%) of such payments within thirty (30) days of receipt of Bluebird’s written invoice therefor, (iii) all recovery-sharing provisions in Section 5.2 and Section 7.2 shall terminate, other than with respect to the
provisions of Section 7.2(e) regarding reimbursement of Bluebird, and any other Third 

  

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COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	
Party licensees of Bluebird, on a pro rata basis for each of their out-of-pocket costs and expenses incurred as a result of cooperating with Celgene as reasonably requested by Celgene in
connection with the action (provided that, for clarity, the rest of the provisions in Section 5.2 and Section 7.2 shall remain in full force and effect, including Bluebird’s right to indemnification and reimbursement of Patent Costs
if joined as a party to any action controlled by Celgene under Section 7.2), (iv) all of the licenses granted to Celgene to Licensed IP thereunder will become fully-paid up other than as set forth in subjection (ii) above,
(v) all of the licenses granted to Celgene to Licensed IP thereunder will become perpetual and non-terminable other than with respect Bluebird In-Licensed IP if, as a result of a breach by Celgene of its obligations under Section 2.8(c),
the applicable Third Party licensor has the right to terminate an Applicable Bluebird In-License pursuant to which such Bluebird In-Licensed IP is licensed to Bluebird, (vi) all obligations of Celgene to commercialize any product will
terminate, (vii) neither Celgene nor its Affiliates shall be subject to the exclusivity provision contained in Section 3.4, provided that if Celgene or its Affiliates are no longer pursuing the Development or Commercialization of the
applicable Licensed Product (including any reasonable periods of customary delay), then the exclusivity provision contained in Section 3.4 shall no longer apply to Bluebird and its Affiliates (and Celgene will provide notice of same to Bluebird
upon Bluebird’s written request), and after such time Celgene will not have any enforcement rights under clause (viii) below with respect to activities under clause (iii) of such “Competitive Infringement” definition,
(viii) Celgene will have the exclusive right to institute and prosecute all enforcement claims under Section 7.2 with respect to “Competitive Infringement” (as defined in Section 7.1) for which Celgene has the first right to
institute such claims (provided that, for clarity, the rest of the provisions in Section 7.2 shall remain in full force and effect, including Bluebird’s right to participate and be involved in any action controlled by Celgene under
Section 7.2, but not a secondary right for Bluebird to institute any such enforcement claim with respect to Competitive Infringement), (ix) the technology transfer obligations under Section 2.3 of the License Agreement will include,
but not be limited to, the obligation to transfer to Celgene complete and fully annotated Vector maps and sequences, including details of Payloads and any and all nucleic acid constructs, plasmids, cell lines and associated methodologies and
production protocols, and (x) such License Agreement will be appropriately tailored to reflect the above. For clarity, and notwithstanding anything to the contrary herein, no license to Bluebird In-Licensed IP under any License Agreement
described in this Section 1.5(c) shall be deemed to be fully-paid up, it being understood and agreed that in no event shall Celgene be relieved of any obligation to reimburse Bluebird for any In-License Payment within thirty (30) days of
receipt of Bluebird’s written invoice therefor or any obligation to provide Bluebird with written reports pursuant to Section 4.4 in order to confirm any such required payments 

 

	 	d.	 The Parties will enter into a License Agreement in the form attached hereto as Exhibit A with respect to each IND Product Candidate,
Declined Product Candidate and Pre-IND Product Candidate, provided that (i) no royalties will be payable under Section 4.3 of the License Agreement and no Milestone Payments will be payable under Section 4.2 of the

  

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AS AMENDED. 
  

	 	
License Agreement, (ii) with respect to any In-License Payment that becomes due from and after the Call Option Closing, Celgene will reimburse Bluebird for one hundred percent (100%) of
such payments within thirty (30) days of receipt of Bluebird’s written invoice therefor, (iii) all recovery-sharing provisions in Section 5.2 and Section 7.2 shall terminate, other than with respect to the provisions of
Section 7.2(e) regarding reimbursement of Bluebird, and any other Third Party licensees of Bluebird, on a pro rata basis for each of their out-of-pocket costs and expenses incurred as a result of cooperating with Celgene as reasonably
requested by Celgene in connection with the action (provided that, for clarity, the rest of the provisions in Section 5.2 and Section 7.2 shall remain in full force and effect, including Bluebird’s right to indemnification and
reimbursement of Patent Costs if joined as a party to any action controlled by Celgene under Section 7.2), (iv) all of the licenses granted to Celgene to Licensed IP thereunder will become fully-paid up other than as set forth in
subjection (ii) above, (v) all of the licenses granted to Celgene to Licensed IP thereunder will become perpetual and non-terminable other than with respect Bluebird In-Licensed IP if, as a result of a breach by Celgene of its obligations
under Section 2.8(c), the applicable Third Party licensor has the right to terminate an Applicable Bluebird In-License pursuant to which such Bluebird In-Licensed IP is licensed to Bluebird, (vi) all obligations of Celgene to commercialize
any product will terminate, (vii) neither Celgene nor its Affiliates shall be subject to the exclusivity provision contained in Section 3.4, provided that with respect to any Pre-IND Candidates any such exclusivity as applied to Bluebird
and its Affiliates will be as provided in Section 12.4(c) of this Agreement, and provided further that if Celgene or its Affiliates are no longer pursuing the Development or Commercialization of the applicable Licensed Product (including any
reasonable periods of customary delay), then the exclusivity provision contained in Section 3.4 shall no longer apply to Bluebird and its Affiliates (and Celgene will provide notice of same to Bluebird upon Bluebird’s written request), and
after such time Celgene will not have any enforcement rights under clause (viii) below with respect to activities under clause (iii) of such “Competitive Infringement” definition, (viii) Celgene will have the exclusive right
to institute and prosecute all enforcement claims under Section 7.2 with respect to “Competitive Infringement” (as defined in Section 7.1) for which Celgene has the first right to institute such claims (provided that, for
clarity, the rest of the provisions in Section 7.2 shall remain in full force and effect, including Bluebird’s right to participate and be involved in any action controlled by Celgene under Section 7.2, but not a secondary right for
Bluebird to institute any such enforcement claim with respect to Competitive Infringement), (ix) the technology transfer obligations under Section 2.3 of the License Agreement will include, but not be limited to, the obligation to transfer
to Celgene complete and fully annotated Vector maps and sequences, including details of Payloads and any and all nucleic acid constructs, plasmids, cell lines and associated methodologies and production protocols, and (x) such License Agreement
will be appropriately tailored to reflect the above. For clarity, and notwithstanding anything to the contrary herein, no license to Bluebird In-Licensed IP under any License Agreement described in this Section 1.5(d) shall be deemed to be
fully-paid up, it being understood and agreed that in no event shall Celgene be relieved of any obligation to reimburse 

  

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AS AMENDED. 
  

	 	
Bluebird for any In-License Payment within thirty (30) days of receipt of Bluebird’s written invoice therefor or any obligation to provide Bluebird with written reports pursuant to
Section 4.4 in order to confirm any such required payments Celgene will reimburse Bluebird for all costs and expenses incurred by Bluebird in connection with transitioning clinical development responsibilities for such IND Product Candidates
and Pre-IND Product Candidates from Bluebird to Celgene, within thirty (30) days of Celgene’s receipt of an invoice and a reasonably detailed invoice of such costs and expenses from Bluebird therefore. 

 

	1.6	Process for Determination of Call Option Exercise Price. The determination of the Call Option Exercise Price (which determination shall be binding in the event
Celgene exercises the Call Option as provided in Section 1.2 above unless otherwise mutually agreed in accordance with Section 1.6(i)) will be made in accordance with the following process: 

 

	 	a.	A panel of three (3) independent third party firms each of which is either (i) a nationally-recognized investment banking firm or (ii) a
nationally-recognized valuation firm (each a “Valuation Firm”) will be selected by Bluebird and Celgene as promptly as practicable in accordance with the procedures set forth below, but in no event more than five (5) calendar
days after Celgene’s receipt of the Call Option Triggering Event Notice. The Parties will share equally in the costs of the Valuation Firms in this process (regardless of outcome). 

 

	 	b.	Bluebird and Celgene will mutually appoint one Valuation Firm who (A) in the prior two (2) years has not had, does not have and does not anticipate having any
material commercial or other business relationship with Bluebird or Celgene or any of their respective Affiliates and (B) with the respect to the lead representative in charge of such assignment contemplated by this Section 1 on behalf of
such Valuation Firm (the “Valuation Manager”), such Valuation Manager has at least ten (10) years professional experience in the valuation of biopharmaceutical development programs as an investment banker, valuation expert or
healthcare consultant (such experience referenced in this clause (B), the “Requisite Experience”), which Valuation Firm shall be proposed by Bluebird and approved by Celgene (which approval shall not be unreasonably withheld or
delayed) (the “Bluebird Designee”). 

  

	 	c.	Celgene and Bluebird will mutually appoint one Valuation Firm who (A) in the prior two (2) years has not had, does not have and does not anticipate having any
material commercial or other business relationship with Bluebird or Celgene or any of their respective Affiliates, and (B) with respect to the applicable Valuation Manager, such Valuation Manager has the Requisite Experience, which Valuation
Firm shall be proposed by Celgene and approved by Bluebird (which approval shall not be unreasonably withheld or delayed) (the “Celgene Designee”). 

 

	 	d.	 Celgene and Bluebird will mutually appoint a third Valuation Firm who (A) in the prior two (2) years has not had, does not have and does not
anticipate having any material 

  

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AS AMENDED. 
  

	 	
commercial or other business relationship with Bluebird or Celgene or any of their respective Affiliates, and (B) with respect to the applicable Valuation Manager, such Valuation Manager has
the Requisite Experience, which Valuation Firm must be mutually approved by both Bluebird and Celgene (which approval shall not be unreasonably withheld or delayed by either Party) (the “Final Designee”). 

 

	 	e.	The engagement of the Valuation Firms selected shall be limited to the determination of the Call Option Exercise Price. In determining the Call Option Exercise Price,
the Valuation Firms shall render their judgment as to what an independent Third Party would pay to Bluebird to acquire its rights and assume its obligations (including the unilateral exclusivity afforded to Celgene under the agreements referenced
above and the In-License Payments that become due and payable by Celgene from and after the Call Option Closing, but excluding the Target Antigen License and all other rights described in Section 1.8 below), including without limitation the
right to receive future payments and perform obligations under any existing Co-Development, Co-Promote and Profit Share Agreement or License Agreement for Licensed Products (which shall take into account the rights and obligations associated solely
with the co-promotion of Licensed Products by such independent Third Party and not any other products such Third Party may have the right to promote or sell) as well as for any IND Product Candidate, Declined Product Candidate or Pre-IND Product
Candidate that is not the subject of an existing Co-Development, Co-Promote and Profit Share Agreement or License Agreement, as set forth in Section 1.5; it being understood that in no event will the Call Option Exercise Price include any value
attributable to the Target Antigen License or other rights described in Section 1.8 below. Each of the Valuation Firms selected shall agree to complete the terms of its engagement within the time period prescribed hereunder. Each of Bluebird
and Celgene shall provide reasonable access to its information and personnel, at reasonable times and on a reasonable number of occasions, to the Valuation Firms as may be reasonably necessary for the Valuation Firms to determine the Call Option
Exercise Price, upon such Valuation Firm entering into a confidentiality agreement on terms reasonably satisfactory to the disclosing Party. 

  

	 	f.	In the event that Celgene fails to exercise the Call Option by delivery of the Call Option Exercise Notice to Bluebird or otherwise delivers written notice to Bluebird
of its decision not to exercise the Call Option, in either case, prior to the expiration of the Call Option Exercise Period, then the procedures specified in this Section 1.6 will automatically terminate, without any obligation on either Party
to consummate the Call Option. 

  

	 	g.	 In the event that Celgene exercises the Call Option by delivery of the Call Option Exercise Notice to Bluebird prior to the expiration of the Call
Option Exercise Period, then no later than the expiration of the Call Option Exercise Period, each Party will have the opportunity to provide the Valuation Firms, on a confidential basis, with a written memorandum (not to exceed [***] words),
including supporting analysis and documentary evidence where appropriate, which such Party deems appropriate to assist 

  

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AS AMENDED. 
  

	 	
the Valuation Firms in determining the Call Option Exercise Price, provided that neither Party shall submit a proposed Call Option Exercise Price. Neither Party shall be entitled to review any
such memorandum or supporting analysis and documentary evidence submitted by the other Party. 

  

	 	h.	The Valuation Firms will have the right to meet with the Parties as necessary to inform the Valuation Firms’ determination of the Call Option Exercise Price. Upon
the expiration of the Valuation Period (the “Initial Valuation Determination Date”), each of the Bluebird Designee and the Celgene Designee will provide to both Parties their respective determinations of the Call Option Exercise
Price. The final Call Option Price will be the average of these two amounts, unless one of the Call Option Prices submitted exceeds the other Call Option Price by [***] or more, in which case both Call Option Prices shall then be submitted to the
Final Designee which Valuation Firm shall determine, no later than two (2) business days after the Initial Valuation Determination Date (the “Final Valuation Determination Date”), a final Call Option Price [***]. The final
Option Price, as determined in accordance with the foregoing process, will be binding and enforceable on the Parties. 

  

	 	i.	Notwithstanding any other provision of this Section 1.6, the Parties may at any time following Celgene’s receipt of the Call Option Triggering Event Notice
and during the valuation process but prior to the Initial Valuation Determination Date or the Final Valuation Date, as applicable, engage in negotiations to determine a mutually-satisfactory Call Option Exercise Price. In the event the Parties agree
in writing as to the amount of the Call Option Exercise Price, the valuation process described in this Section 1.6 shall terminate and the Call Option Exercise Price shall be the amount agreed to in writing by the Parties which amount shall be
binding and enforceable on the Parties. 

  

	1.7	Miscellaneous Provisions Relating to Exercise of the Call Option. In connection with the exercise and consummation of the Call Option as contemplated herein:

  

	 	a.	The Parties will take or cause to be taken all such actions as may be reasonably necessary or desirable in order to give effect to the actions described in this Exhibit
L and any related transactions, including executing, acknowledging and delivering consents, assignments, waivers and other documents and instruments; furnishing information and copies of documents; filing applications, reports, returns, filings and
other documents or instruments with governmental authorities; and otherwise cooperating with the other Party as applicable. For clarity, Bluebird covenants and agrees to transfer all of its rights to receive payments contemplated to be transferred
to Celgene at the Call Option Closing free of all liens, charges and other encumbrances (and Bluebird shall be financially responsible for eliminating and satisfying all such liens, charges and encumbrances). 

 

	 	b.	 Except as otherwise expressly provided in this Exhibit L (including the requirement of Celgene to pay all fees required to be paid to any government
authority in connection 

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	
with any HSR Filing as set forth in Section 1.4 above), each of the Parties will be responsible for its own costs and expenses incurred in connection with the transactions contemplated by
this Exhibit L (whether or not consummated), including all attorneys’ fees and charges, all accounting fees and charges and all investment banking fees, charges or commissions. 

 

	 	c.	Any information disclosed to Celgene or Bluebird in accordance with this Exhibit L, including the information provided in accordance with Section 1.2 above, and
the existence of a Call Option Triggering Event or the fact that discussions or negotiations are taking place concerning the Call Option, or any of the terms, conditions or other facts with respect thereto, or the outcome thereof, shall (i) be
deemed to be the Confidential Information of the disclosing Party, (ii) be used by the recipient Party solely for purposes of evaluating and exercising its interest and obligations regarding the Call Option and the matters referred to in this
Exhibit L and for no other purpose, and (iii) shall otherwise be subject to the restrictions on disclosure and exceptions thereto set forth in Section 10 of this Agreement. 

 

	1.8	Target Antigen License if Call Option Exercised Prior to Third Anniversary of the Effective Date. In the event that Celgene exercises the Call Option by
delivering the Call Option Exercise Notice to Bluebird prior to the expiration of the applicable Call Option Exercise Period and prior to the third anniversary of the Effective Date of the Agreement, then upon the effectiveness of the Call Option
Closing, if any, in addition to the consummation of the matters contemplated by Section 1.5 above in consideration of the payment required to be made as contemplated by Section 1.3 above, the Parties will also enter into a License
Agreement in the form attached hereto as Exhibit A, modified as follows: 

  

	 	a.	Bluebird will grant Celgene a perpetual, non-terminable, worldwide, exclusive (even as to Bluebird and its Affiliates) license, with the right to sublicense as
permitted by Section 3.4 of such License Agreement, under Licensed IP to Develop and Commercialize Licensed Products in the Field, provided that such license will not be non-terminable with respect to Bluebird In-Licensed IP if, as a result of
a breach by Celgene of its obligations under Section 2.8(c), the applicable Third Party licensor has the right to terminate an Applicable Bluebird In-License pursuant to which such Bluebird In-Licensed IP is licensed to Bluebird;

  

	 	i.	“Licensed IP” will be defined to mean Patents, Materials and Know-How Controlled by Bluebird or any of its Affiliates (including any applicable
Collaboration IP and Bluebird Technology), including Bluebird In-Licensed IP, that are necessary or useful to Develop and Commercialize Licensed Products; 

  

	 	ii.	“Licensed Products” will be defined to mean any and all therapeutic candidates in the Field; and 

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	iii.	“Target Antigens” will be defined to mean any and all oncology associated antigens, provided that from and after the third anniversary of the Effective
Date of the Agreement, “Target Antigens” will be limited to the oncology associated antigens designated by Celgene in a written notice to Bluebird as those oncology associated antigens for which Celgene reasonably intends to Develop
Licensed Products, which written notice will be delivered to Bluebird within thirty (30) days after the third anniversary of the Effective Date of the Agreement, provided further that from and after the fifth anniversary of the Effective Date
of the Agreement, “Target Antigens” will be limited to the oncology associated antigens “in development” and identified as such by Celgene in a written notice to Bluebird, which written notice will be delivered to Bluebird within
thirty (30) days after the fifth anniversary of the Effective Date of the Agreement. For purposes of this Section 1.8(a)(iii), an oncology associated antigen will be deemed “in development” when at least one in vitro assay of a
chimeric antigen receptor (CAR) construct targeting such oncology associated antigen, or of a genetically modified T cell targeting such oncology associated antigen, has been initiated; 

 

	 	b.	with respect to each Licensed Product, (i) Celgene will pay a royalty of [***] percent ([***]%) of worldwide Net Sales of such Licensed Product under
Section 4.3(a) of the License Agreement (subject to the provisions of Sections 4.3(b)-(f)), and no other royalties will be payable under Section 4.3 of the License Agreement, (ii) Celgene will pay a milestone payment of [***]
(U.S.$[***]) under Section 4.2 of the License Agreement upon the earlier of (A) Regulatory Approval of a BLA in the United States by the FDA for such Licensed Product or (B) Regulatory Approval of an MAA by the EMA for such Licensed
Product, and no other milestone payments will be payable under Section 4.2 of the License Agreement (including for any Licensed Product that is approved for multiple indications), provided that it is further agreed that no milestone payment
will be payable for any improved or modified version of a Licensed Product for which the [***] (U.S.$[***]) previously had been paid; 

  

	 	c.	with respect to any In-License Payment that becomes due from and after the Call Option Closing, Celgene will reimburse Bluebird for one hundred percent (100%) of
such payments within thirty (30) days of receipt of Bluebird’s written invoice therefor; 

  

	 	d.	all recovery-sharing provisions in Section 5.2 and Section 7.2 shall terminate, other than with respect to the provisions of Section 7.2(e) regarding
reimbursement of Bluebird, and any other Third Party licensees of Bluebird, on a pro rata basis for each of their out-of-pocket costs and expenses incurred as a result of cooperating with Celgene as reasonably requested by Celgene in connection with
the action (provided that, for clarity, the rest of the provisions in Section 5.2 and Section 7.2 shall remain in full force and effect, including Bluebird’s right to indemnification and reimbursement of Patent Costs if joined as a
party to any action controlled by Celgene under Section 7.2); 

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	e.	all obligations of Celgene to develop and/or commercialize any product will terminate, and Sections 2.6 (Annual Update Meetings), 2.7 (Reports by Celgene) and 2.8(b)
(Maintenance of Celgene Licensed Product In-Licenses) will not apply; 

  

	 	f.	Bluebird and its Affiliates will be subject to the exclusivity provision contained in Section 3.4 with respect to all Target Antigens and products that target the
Target Antigens (removing the reference to Elected Candidates), provided that if, after five (5) years from the Effective Date, Celgene or its Affiliates are no longer pursuing the Development (it being understood that if a Licensed Product is
“in development” (as defined in Section 1.8(a)(iii)), then Celgene will be deemed to be pursuing the Development of such Licensed Product) or Commercialization of the applicable Licensed Product (including any reasonable periods of
customary delay), then the exclusivity provision contained in Section 3.4 shall no longer apply to Bluebird and its Affiliates with respect to such applicable Licensed Product and the Target Antigen targeted by such applicable Licensed Product
(but only if Celgene is not pursuing the Development or Commercialization of other Licensed Products targeting such Target Antigen) (and Celgene will provide notice of same to Bluebird upon Bluebird’s written request), and after such time
Celgene will not have any enforcement rights under clause (g) below with respect to activities under clause (iii) of such “Competitive Infringement” definition, and neither Celgene nor its Affiliates shall be subject to the
exclusivity provision contained in Section 3.4; 

  

	 	g.	Celgene will have the exclusive right to institute and prosecute all enforcement claims under Section 7.2 with respect to “Competitive Infringement” (as
defined in Section 7.1) for which Celgene has the first right to institute such claims (provided that, for clarity, the rest of the provisions in Section 7.2 shall remain in full force and effect, including Bluebird’s right to
participate and be involved in any action controlled by Celgene under Section 7.2, but not a secondary right for Bluebird to institute any such enforcement claim with respect to Competitive Infringement); 

 

	 	h.	the technology transfer obligations under Section 2.3 of the License Agreement will include, but not be limited to, the obligation to transfer to Celgene complete
and fully annotated Vector maps and sequences, including details of Payloads and any and all nucleic acid constructs, plasmids, cell lines and associated methodologies and production protocols; 

 

	 	i.	such License Agreement will be appropriately tailored to reflect the above; and 

 

	 	j.	For clarity, and notwithstanding anything to the contrary herein, no license to Bluebird In-Licensed IP under any License Agreement described in this Section 1.8
shall be deemed to be fully-paid up, it being understood and agreed that in no event shall Celgene be relieved of any obligation to reimburse Bluebird for any In-License Payment within thirty (30) days of receipt of Bluebird’s written
invoice therefor or any obligation to provide Bluebird with written reports pursuant to Section 4.4 in order to confirm any such required payments. 

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

 For avoidance of doubt, the License Agreement contemplated by this Section 1.8 is separate from any
amended License Agreement executed pursuant to Section 1.5(c) above or License Agreement entered into pursuant to Sections 1.5(b) or 1.5(d) above, and the terms of this Section 1.8 shall not apply to any License Agreement amended pursuant
to Section 1.5(c) above or entered into pursuant to Sections 1.5(b) or 1.5(d) above. 
  

	1.9	License Agreements. Further, with respect to any License Agreement amended pursuant to Section 1.5(c) above or entered into pursuant to Sections 1.5(b),
1.5(d) or 1.8(a) above, (i) Bluebird will have no obligation to continue the performance of any Phase 1 Study under Section 2.1 (a) of such License Agreement, (ii) Section 11.2(a) of such License Agreement will apply to the
items listed therein based on the applicable Corporate Event, and (iii) the exclusivity restrictions in Section 3.4 of such License Agreement will continue to be subject to the exceptions set forth in such Section 3.4.

  

	1.10	Expiration of Call Right Exercise. In the event that Celgene exercises the Call Option by delivery of written notice to Bluebird prior to the expiration of the
Call Option Exercise Period and (1) Bluebird gives Celgene written notice that the applicable Call Option Triggering Event is no longer in effect or (2) a Corporate Event is not publicly announced within nine (9) months following the
applicable Call Option Triggering Event Notice, then (a) the above-mentioned Call Option Exercise Notice shall be deemed rescinded, null and void, and (b) if during the remaining portion of the Call Option Period, a subsequent Call Option
Triggering Event occurs, the procedures set forth in this Exhibit L will apply with respect to such subsequent Call Option Triggering Event. 

  

	1.11	Termination. Celgene’s right to exercise the Call Option as set forth in this Exhibit L will terminate upon the earlier of: 

 

	 	a.	the consummation of a Corporate Event unless a Call Option Exercise Notice has been timely delivered by Celgene in accordance with Section 1.2 following a Call
Option Triggering Event, prior to the expiration or termination of the Call Option Exercise Period and prior to consummation of such Corporate Event, in which case Celgene’s right to exercise the Call Option shall continue as contemplated by
this Exhibit L (it being understood and agreed that, in the event of any failure by Bluebird to comply with the terms and conditions of Sections 1.1 and 1.2, Celgene’s right to exercise the Call Option shall not terminate);

  

	 	b.	the expiration or termination of the Call Option Period unless a Call Option Exercise Notice has been timely delivered by Celgene in accordance with Section 1.2
following a Call Option Triggering Event and prior to the expiration or termination of the Call Option Exercise Period, in which case Celgene’s right to exercise the Call Option shall continue as contemplated by this Exhibit L; and

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	c.	the expiration or termination of this Agreement unless a Call Option Exercise Notice has been timely delivered by Celgene in accordance with Section 1.2 following
a Call Option Triggering Event, prior to the expiration or termination of the Call Option Exercise Period and prior to the expiration or termination of this Agreement, in which case Celgene’s right to exercise the Call Option shall continue as
contemplated by this Exhibit L. 

  

	1.12	Attorneys’ Fees. In any suit or proceeding between the Parties brought in accordance with Section 13.1 of the Agreement that relates to an allegation
that a Party has breached its obligations under this Exhibit L in a manner that adversely affects the other Party’s rights hereunder with respect to the exercise and execution of the Call Option, the prevailing Party will have the right
to recover from the other Party its documented costs and reasonable fees and expenses of attorneys, accountants, and other professionals incurred in connection with the suit or proceeding. For clarity, this Section 1.12 will apply solely with
respect to suits or proceedings relating to the exercise and execution of the Call Option, and does not apply with respect to any other suit or proceeding related to or arising out of (i) this Agreement, (ii) any Development &
Commercialization Agreement, or (iii) any License Agreement entered into pursuant to Section 1.8 above, amended License Agreement executed pursuant to Section 1.5(c) above or License Agreement entered into pursuant to Sections 1.5(b)
or 1.5(d) above. 

  

	1.13	Definitions. For purposes of this Exhibit L: 

  

	 	a.	“Bluebird Call Option Triggering Event” means any determination by the board of directors of Bluebird to commence a process reasonably intended to
result (or does then result) in a Corporate Event. 

  

	 	b.	“Call Option” means (i) Celgene’s right to acquire the licenses together with the other matters described in Section 1.5 in
consideration of the payment by Celgene of the Call Option Exercise Price in accordance with the procedures described in this Exhibit L and (ii) if, and only if, the Call Option is exercised prior to the third anniversary of the Effective Date
of the Agreement, Celgene’s right to acquire the Target Antigen License together with the other matters described in Section 1.8 in consideration of the payment obligations set forth in Section 1.8 in accordance with the procedures
described in this Exhibit L. 

  

	 	c.	 “Call Option Exercise Period” means the twelve (12) calendar day period following Celgene’s receipt of the Call Option
Triggering Event Notice, provided that Bluebird may extend the Call Option Exercise Period as follows: (i) in ten (10) day increments following the end of the then-existing “Call Option Exercise Period” by delivery of written
notice to Celgene at any time prior to the fifth
(5th) day prior to the expiration of such Call Option
Exercise Period (as it may be extended from time to time), and (ii) the extensions, when aggregated together, may not exceed 240 days in the aggregate. In the event the Call Option Exercise Period is extended as provided in the immediately

  

 CERTAIN CONFIDENTIAL PORTIONS OF THIS EXHIBIT WERE OMITTED AND REPLACED WITH “[***]”. A
COMPLETE VERSION OF THIS EXHIBIT HAS BEEN FILED SEPARATELY WITH THE SECRETARY OF THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO AN APPLICATION REQUESTING CONFIDENTIAL TREATMENT PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933,
AS AMENDED. 
  

	 	
preceding sentence, the Valuation Period will also be extended for a like number of calendar days. In the event that the Call Option Exercise Period is scheduled to expire on a calendar day that
is not a business day, then the Call Option Exercise Period shall automatically be extended until the next business day. 

  

	 	d.	“Call Option HSR Clearance Date” means the earliest date on which the Parties have actual knowledge that all applicable waiting periods under the HSR
Act with respect to the transactions contemplated by the Call Option have expired or have been terminated. 

  

	 	e.	“Call Option Triggering Event” means (i) a Bluebird Call Option Triggering Event or (ii) a Third Party Call Option Triggering Event.

  

	 	f.	“Third Party Call Option Triggering Event” means (i) the receipt by Bluebird of a bona fide written offer by a Third Party with respect to
a Corporate Event subsequent to which the board of directors of Bluebird determines, subject to compliance with this Agreement, to enter into negotiations with such Third Party with respect to such Corporate Event or (ii) the public
announcement by a Third Party of an intention to effect a Corporate Event. 

  

	 	g.	“Valuation Period” means the fifteen (15) calendar day period following Celgene’s receipt of the Call Option Triggering Event Notice, subject
to extension as set forth in Section 1.13(c) above, provided that Bluebird may further extend the Valuation Period by delivery of written notice to Celgene at any time prior to the expiration of the Valuation Period (as it may be extended from
time to time) as and to the extent permitted by Section 1.13(c) above. In the event that the Valuation Period is scheduled to expire on a calendar day that is not a business day, then the Valuation Period shall automatically be extended until
the next business day.EX-10.18

 Exhibit 10.18 
 BLUEBIRD BIO, INC. 
  

 
 EXECUTIVE CASH
INCENTIVE BONUS PLAN 
  

	1.	Purpose 

 This Executive
Cash Incentive Bonus Plan (the “Incentive Plan”) is intended to provide an incentive for superior work and to motivate eligible executives of bluebird bio, Inc. (the “Company”) and its subsidiaries
toward even higher achievement and business results, to tie their goals and interests to those of the Company and its stockholders and to enable the Company to attract and retain highly qualified executives. The Incentive Plan is for the benefit of
Covered Executives (as defined below). 
  

	2.	Covered Executives 

 From
time to time, the Compensation Committee of the Board of Directors of the Company (the “Compensation Committee”) may select certain key executives (the “Covered Executives”) to be eligible to receive
bonuses hereunder. Participation in this Plan does not change the “at will” nature of a Covered Executive’s employment with the Company. 
  

	3.	Administration 

 The
Compensation Committee shall have the sole discretion and authority to administer and interpret the Incentive Plan. 
  

	4.	Bonus Determinations 

 (a)
Corporate Performance Goals. A Covered Executive may receive a bonus payment under the Incentive Plan based upon the attainment of one or more performance objectives that are established by the Compensation Committee and relate to financial
and/or operational metrics with respect to the Company or any of its subsidiaries (the “Corporate Performance Goals”), including the following: achievement of specified research and development, publication, clinical and/or
regulatory milestones, cash flow (including, but not limited to, operating cash flow and free cash flow); sales or revenue; corporate revenue; ]earnings before interest, taxes, depreciation and amortization; net income (loss) (either before or after
interest, taxes, depreciation and/or amortization); changes in the market price of the Company’s common stock; economic value-added; funds from operations or similar measure; acquisitions or strategic transactions; operating income (loss);
return on capital, assets, equity, or investment; stockholder returns; return on sales; gross or net profit levels; productivity; expense efficiency; margins; operating efficiency; customer satisfaction; working capital; earnings (loss) per share of
the Company’s common stock; bookings, new bookings or renewals; sales or market shares; number of customers, number of new customers or customer references; operating income and/or net annual recurring revenue, any of which may be
(A) measured in absolute terms or compared to any incremental increase, (B) measured in terms of growth, (C) compared to another company or companies or to results of a peer group, (D) measured against the market as a whole
and/or as 

 
compared to applicable market indices and/or (E) measured on a pre-tax or post-tax basis (if applicable). Further, any Corporate Performance Goals may be used to measure the performance of
the Company as a whole or a business unit or other segment of the Company, or one or more product lines or specific markets. The Corporate Performance Goals may differ from Covered Executive to Covered Executive. 

(b) Calculation of Corporate Performance Goals. At the beginning of each applicable performance period, the Compensation Committee
will determine whether any significant element(s) will be included in or excluded from the calculation of any Corporate Performance Goal with respect to any Covered Executive. In all other respects, Corporate Performance Goals will be
calculated in accordance with the Company’s financial statements, generally accepted accounting principles, or under a methodology established by the Compensation Committee at the beginning of the performance period and which is consistently
applied with respect to a Corporate Performance Goal in the relevant performance period. 
 (c) Target; Minimum; Maximum.
Each Corporate Performance Goal shall have a “target” (e.g., 100 percent attainment of the Corporate Performance Goal) and may also have a “minimum” hurdle and/or a “maximum” amount. 

(d) Bonus Requirements; Individual Goals. Except as otherwise set forth in this Section 4(d), to the extent practicable under
the circumstances: (i) any bonuses paid to Covered Executives under the Incentive Plan shall be based upon objectively determinable bonus formulas that tie such bonuses to one or more performance targets relating to the Corporate Performance
Goals, (ii) bonus formulas for Covered Executives shall be adopted in each performance period by the Compensation Committee and communicated to each Covered Executive at the beginning of each performance period and (iii) no bonuses shall
be paid to Covered Executives unless and until the Compensation Committee makes a determination with respect to the attainment of the performance targets relating to the Corporate Performance Goals. Notwithstanding the foregoing, the Compensation
Committee may adjust bonuses payable under the Incentive Plan based on achievement of one or more individual performance objectives or pay bonuses (including, without limitation, discretionary bonuses) to Covered Executives under the Incentive Plan
based on individual performance goals and/or upon such other terms and conditions as the Compensation Committee may in its discretion determine. 
 (e) Individual Target Bonuses. The Compensation Committee shall establish a target bonus opportunity for each Covered Executive for each performance period. For each Covered Executive, the
Compensation Committee shall have the authority to apportion the target award so that a portion of the target award shall be tied to attainment of Corporate Performance Goals and a portion of the target award shall be tied to attainment of
individual performance objectives. 
 (f) Employment Requirement. Subject to any additional terms contained in a written
agreement between the Covered Executive and the Company, the payment of a bonus to a Covered Executive with respect to a performance period shall be conditioned upon the Covered Executive’s employment by the Company on the bonus payment date.
If a Covered Executive was not employed for an entire performance period, the Compensation Committee may pro rate the bonus based on the number of days employed during such period. 

  
 2 

	5.	Timing of Payment 

 (a)
The Corporate Performance Goals will be measured at the end of each performance period after the Company’s financial reports with respect to such period(s) have been published. If the Corporate Performance Goals and/or individual goals for such
period are met, payments will be made as soon as practicable following the end of such period, but not later 74 days after the end of the fiscal year in which such performance period ends. 

(b) With respect to Corporate Performance Goals established and measured on an annual or multi-year basis, Corporate Performance Goals
will be measured as of the end of each such performance period (e.g., the end of each fiscal year) after the Company’s financial reports with respect to such period(s) have been published. If the Corporate Performance Goals and/ or
individual goals for any such period are met, bonus payments will be made as soon as practicable, but not later than 74 days after the end of the relevant fiscal year. 
 (c) For the avoidance of doubt, bonuses earned at any time in a fiscal year must be paid no later than 74 days after the last day of such fiscal year. 

 

	6.	Amendment and Termination 

The Company reserves the right to amend or terminate the Incentive Plan at any time in its sole discretion. 

ADOPTED BY THE BOARD OF DIRECTORS: May 5, 2013 

  
 3

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