Document:

Exhibit 10.3

 

FRAMEWORK
RESEARCH AND OPTION AGREEMENT

 

This
Framework Research and Option Agreement (“Agreement”) is made in Jerusalem this 31st day of July, 2022, and shall
be effective retroactively as of the 1st day of October, 2021 (the “Effective Date”), by and between:

 

YISSUM
RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF

JERUSALEM
LTD., of Hi Tech Park, Edmond J. Safra Campus, Givat Ram, Jerusalem 91390, Israel (“Yissum”) of the first part;
and

 

CLEARMIND
MED Ltd. , of 20 Raoul Wallenberg St. Tel-Aviv; on behalf of itself and its Affiliates (the “Company”), of the second
part;

 

(each
of Yissum and the Company, a “Party”, and collectively the “Parties”)

 

	WHEREAS:	pursuant
to the regulations of the University, the rights and title to all inventions, know-how and research results of scientists of the Hebrew
University of Jerusalem (“HUJ”) vest solely with Yissum; and

 

	WHEREAS:	the
Company may, from time to time, wish to fund, and Yissum may from time to time agree, to obtain the performance of, certain research
by the Researcher(s) (“each individually a ’Research Project”), relating to various subjects as may be determined
and agreed between the Parties on a case by case basis; and in each such event the Parties shall enter into a Research Statement of Work
(“SOW” as further detailed below) that will be governed by the provisions of this Agreement.

 

	WHEREAS:	To
the extent that a Research is successful, the Company may consider taking, subject to its sole discretion, a license to the applicable
Research Results and, if applicable, to any relevant Patent (as such terms are defined below) in accordance with agreed upon commercial
and other terms and conditions as shall be set forth in a the applicable SOW; and

 

	WHEREAS:	Yissum
agrees to obtain the performance of the Research, all in accordance with the terms and conditions of this Agreement.

 

NOW
THEREFORE THE PARTIES DO HEREBY AGREE AS FOLLOWS:

 

	1.	Interpretation
                                            and Definitions

 

		1.1.	The
                                            preamble and appendices annexed to this Agreement constitute an integral part hereof and
                                            shall be read jointly with its terms and conditions.

 

		1.2.	In
                                            this Agreement, unless otherwise required or indicated by the context, the singular shall
                                            include the plural and vice-versa, the masculine gender shall include the female gender,
                                            and the use of the word “or” shall mean “and/or”.

 

		1.3.	The
                                            headings of the sections in this Agreement are for the sake of convenience only and shall
                                            not serve in the interpretation of the Agreement.

 

		1.4.	In
                                            this Agreement, capitalized terms shall have the meaning set forth herein:

 

		1.4.1.	“Patent”
shall mean the patent/s or application/s, if and as, referenced in an applicable SOW; and all patent applications claiming priority therefrom
as well as all and all enhancements, improvements, derivatives, divisions, continuations, continuations-in-part, re-examinations, reissues,
renewals, registrations, confirmations, substitutions, or extensions, or any other similar statutory protection, and any provisional
applications, of any such patents or patent applications, and any and all patents issuing from, and patentable inventions, methods, processes,
and other patentable subject matter disclosed or claimed in, any or all of the foregoing.

 

     

     

    

 

		1.4.2.	“Affiliates”
                                            shall mean any person, organization or other legal entity which controls, or is controlled
                                            by, or is under common control with, the Company.

 

		1.4.3.	“Control”
                                            shall mean the holding of more than fifty percent (50%) of (i) the equity, or (ii) the voting
                                            rights, or (iii) the right to elect or appoint directors.

 

		1.4.4.	“Research
                                            Project” shall mean the specific research to be conducted by the Researcher(s)
                                            pursuant to an applicable Research Program, all as defined and set forth in a corresponding
                                            SOW (as set forth in Section 2 below).

 

		1.4.5.	“Research
                                            Budget” shall mean with respect to each Research Project - the research budget set
                                            forth in the corresponding SOW.

 

		1.4.6.	“Research
                                            Results Patents” shall mean any and all patent applications and patents deriving
                                            out of the performance of a Research Project, covering any portion or part of the applicable
                                            Research Results; and all patent applications claiming priority therefrom as well as all
                                            and all enhancements, improvements, derivatives, divisions, continuations, continuations-in-part,
                                            re-examinations, reissues, renewals, registrations, confirmations, substitutions, or extensions,
                                            or any other similar statutory protection, and any provisional applications, of any such
                                            patents or patent applications, and any and all patents issuing from, and patentable inventions,
                                            methods, processes, and other patentable subject matter disclosed or claimed in, any or all
                                            of the foregoing.

 

		1.4.7.	“Research
                                            Period” shall mean with respect to each applicable Research Project the period
                                            defined in the corresponding applicable SOW.

 

		1.4.8.	“Research
                                            Program” shall mean the program under which the a specific Research Project shall
                                            be funded by the Company and carried out and conducted by the Researcher/s, as set forth
                                            in the applicable SOW.

 

		1.4.9.	“Research
                                            Results” shall mean all results generated from the performance of a specific Research
                                            Project, including, but not limited to, methods, process, technique, data, information, discoveries,
                                            inventions, materials, devices or know- how arising therefrom, or the applicable Research
                                            Results Patents.

 

		1.4.10.	“Researcher(s)”
                                            shall mean, with respect to each Research Project, the researcher(s) appointed by Yissum
                                            to supervise and to perform the Research Project as shall be set forth in the applicable
                                            SOW.

 

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		1.4.11.	“SOW”
                                            shall mean a statement of work, to which the Parties may enter form time to time, which are
                                            duly executed by the Parties and which define a Research Project, and shall include a Research
                                            Program, names of the Researcher(s), the Research
Period, Research Budget; and the Progress Reports to be provided to Company.

 

		1.4.12.	“Territory”
                                            shall mean worldwide.

 

	2.	The
                                            Research Project

 

		2.1.	The
                                            Parties may agree from time to time that Yissum, via its researchers, will conduct one of
                                            more Research Project to be financed by the Company, all in accordance with a SOW. Once the
                                            Parties decide to begin a new Research Project, the Parties shall enter into a suitable SOW.
                                            Each SOW shall, collectively with this Agreement, independent from other SOW, constitute
                                            the entire agreement for the specific Research Project, and shall be governed by the terms
                                            of this Agreement.

 

		2.2.	The
                                            Company hereby undertakes to finance performance of a Research Project in accordance with
                                            a Research Program and Research Budget, all to be set forth in the applicable SOW. Each SOW
                                            shall set forth a mutually agreed upon research fee (inclusive of overhead), plus VAT, if
                                            applicable (the “Research Fee”), payable in accordance with the payment schedule
                                            to be set forth in the Research Budget, as referenced and set forth in the applicable SOW.
                                            Such financing shall be, subject to any earlier termination of the specific Research Project
                                            pursuant to this section 2.2, below, in an amount as shall be set forth in the applicable
                                            SOW. Because the allocation of expenses in any Research Budget is based on expected expense
                                            categories and an expected allocation of specific expenses within each category, such categories
                                            and the allocation of expenses among the various expense categories may be modified by the
                                            Researcher/s, where reasonably necessary or appropriate during the Research Period, provided
                                            that Researcher(s) have obtained the Company’s prior written consent to such modification;
                                            it being agreed, however that the aggregate Research Fee shall not be increased without the
                                            written consent of the Company. Any such modifications shall be agreed in writing as an amendment
                                            to the applicable SOW. Payments may be made by check or by wire transfer to the following
                                            account:

 

Name
of Bank: *****

Bank
Key: *****

Bank’s
address: *****

Branch:
*****

Bank
account Number: *****

Swift
Code: *****

IBAN:
*****

 

The
Company shall always use the payment information provided above. The Company shall not accept any changes in respect of the payment route
or bank account details that are received via email, facsimile or by other means of communication, including, without limitation, any
invoice or other written request for payment, unless such changes are set forth in an amendment to this Agreement on the letterhead of
Yissum signed by its Chief Financial Officer or Controller. If the Company breaches this provision, it shall bear any financial loss
or other consequences arising therefrom and shall indemnify Yissum for any such loss or damages that may be incurred by Yissum.

 

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		2.3.	Each
                                                                                                                                                                                                                                        Research Project shall be conducted by and under the supervision of the Researcher(s). Should any of the Researchers be unable to
                                                                                                                                                                                                                                        complete a Research Project for any reason, Yissum shall notify the Company in writing, and may propose a suitable replacement
                                                                                                                                                                                                                                        researcher. The Parties shall discuss the identity of a replacement, but to the extent the Company does not agree to the suggested
                                                                                                                                                                                                                                        replacement researcher, the Company shall have the right to terminate the specific Research Project and the applicable SOW upon
                                                                                                                                                                                                                                        written notice to Yissum, in which case the provisions of Section 8.3 below shall apply.

 

		2.4.	Yissum
                                            shall provide the Company with twice-yearly progress reports as set forth in the applicable
                                            SOW (“Progress Reports”). Such Progress Reports may be used by the Company
                                            for advertising and marketing purposes and may be publicized for such purposes, provided
                                            that no Confidential Information is disclosed and that such advertising or marketing do not
                                            indicate in any way that Yissum, the Hebrew University of Jerusalem (the “University”),
                                            or the Researcher(s) endorse the Company’s activities. Within thirty (30)
days of the end of the Research Period, Yissum shall present the Company with a written report from the Researcher(s) summarizing the
results of the Research Project during the Research Period (the “Scientific Report”).

 

	3.	Option
                                            to License the Research Results; Ownership of the Research Results and Other Intellectual
                                            Property

 

		3.1	With
                                            respect to each Research Project hereunder, Yissum hereby grants the Company, an exclusive
                                            option (the “Option(s)”) to receive (i) an exclusive royalty-bearing license,
                                            in the Territory, to Yissum’s interest in the Research Results or Research Results
                                            Patents, if any; and (ii) to the extent any Patent is required to practice the Research Results,
                                            a non - exclusive or exclusive license to the Patent solely in the field of the subject matter
                                            of the applicable Research Project as defined in the applicable SOW (the “Field”)
                                            (the “License”); upon commercial terms and conditions which, unless otherwise
                                            set forth in an applicable SOW (following good faith negotiations between the Parties), shall
                                            be as set forth in Appendix A., and on additional other customary terms and conditions,
                                            all to be negotiated in good faith by the Parties (all to be set forth in a license agreement
                                            to be discussed and agreed upon between the Parties (the “License Agreement”).

 

		3.2	The
                                            Company may exercise the Option, at any time from the execution of the applicable SOW, up
                                            to and including one hundred and twenty (120) days from the Company’s receipt of the
                                            Scientific Report provided under the SOW, the “Option Exercise Period”)
                                            by notifying Yissum in writing (the “Option Exercise Notice”).

 

		3.3	Upon
                                            the date of Yissum’s receipt of the Option Exercise Notice within the Option Exercise
                                            Period, Yissum and the Company shall negotiate the terms and conditions of a License Agreement
                                            during a period of up to one hundred and twenty (120) days (with respect to each License
                                            Agreement, the “Negotiation Period”).

 

		3.4	All
                                            rights in the Research Results or the Research Results Patents shall be owned by Yissum,
                                            unless an employee of the Company is properly considered an inventor (according to US law)
                                            of any Research Results Patent, in which event such Research Results Patent shall be owned
                                            jointly by Yissum and the Company (a “Joint Patent”). All rights in any
                                            other intellectual property developed solely by the employees or representatives of one Party
                                            shall belong exclusively to such Party.

 

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		3.5	Notwithstanding
                                            the foregoing in Section 3.4, above, should the Company not exercise an Option within the
                                            Option Exercise Period, or should the Parties fail to execute a License Agreement within
                                            the Negotiation Period despite good-faith negotiations, neither Yissum nor the Researcher(s)
                                            shall have any further obligations towards the Company with respect to
negotiating a License to the applicable Research Results or Research Results Patents, whether solely owned by Yissum or jointly held
with the Company or to the Patent, if applicable. In such event, the Company agrees to take all reasonably necessary actions to assign
its interest in any Joint Patent to Yissum without any compensation to be paid by Yissum to the Company. Thereafter, Yissum shall be
entitled to commercialize or otherwise grant third parties any right or title in and to the Research Results, the Research Results Patents
or the Patent, if applicable according to Yissum’ sole discretion and without any further obligation to the Company.

 

		3.6	With
                                            respect to each Research Project, from the execution of a SOW and until the later of (a)
the end of the applicable Option Exercise Period; or (b) the effective date of the applicable License Agreement; or (c) the expiration
of the applicable Negotiation Period, Yissum: (i) shall not, directly or indirectly, enter into any discussions or agreement with any
third party, including any agreement to license, sell or purchase any rights or interests in or to the Research Results or Research Results
Patents, or to license or sell any exclusive rights in Patent/s, if applicable, that may jeopardize or conflict with the Option, nor
shall it accept, consider, initiate or negotiate any offer from any other person or entity with respect to a collaboration, license,
sale, purchase or other business transaction involving the Research Results, Research Patents or Patent(s), if applicable.

 

	4.	Responsibility
                                            for the Filing and Funding of Research Results Patent Applications

 

		4.1.	If
                                            at any time during the term of this Agreement, a patentable invention arises from a Research
                                            Project,( i.e – that would be deemed a Research Result Patent upon its filing) Yissum,
                                            at the request of the Company, and in consultation with the Company, shall be responsible
                                            for filing an appropriate patent application, and the Company shall be responsible for funding
                                            the costs of the filing, prosecution and maintenance of such application. It is acknowledged
                                            and agreed that to the extent the Company does not exercise the Option regarding the applicable
                                            Research Project for any reason, the Company shall cease payment for the Research Results
                                            Patents.

 

		4.2.	In
                                            the event that the Company does not exercise an Option or, having exercised such Option,
                                            does not execute a License Agreement, Yissum shall assume the responsibility for all future
                                            costs of any Research Results Patents and shall be entitled to license such Research Results
                                            Patents to any party it so chooses.

 

	5.	Confidentiality

 

		5.1.	Each
                                            Party warrants and undertakes to the other that during the term of this Agreement and subsequent
                                            thereto, it shall maintain, and shall be liable for its officers, employees, representatives,
                                            or any other persons acting on its behalf (“Representatives”) maintaining,
                                            full and absolute confidentiality of all information, details and data which is in or comes
                                            to its knowledge or the knowledge of its Representatives, directly or indirectly relating
                                            to a Research Project or the business of the other Party. Each Party undertakes not to convey
                                            or disclose anything in connection with the foregoing to any entity without the prior written
                                            permission of the Party which disclosed such confidential information.

 

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		5.2.	The
                                            obligation contained in this section shall not apply to information which:

 

		(a)	is
                                            in the public domain as of the date of this Agreement or hereafter comes into the public
                                            domain through no fault of a Party, its officers, employees, representatives or persons acting
                                            on its behalf; or

 

		(b)	a
                                            Party can demonstrate through tangible evidence was in its possession before receipt from
                                            the disclosing Party or its Affiliates; or

 

		(c)	the
                                            Party can demonstrate through tangible evidence was developed independently by that Party
                                            without reference to or reliance upon the disclosing Party’s information; or

 

		(d)	was
                                            disclosed to the Party without restriction on disclosure by a third party who has the lawful
                                            right to disclose such information.

 

		5.3.	Notwithstanding
                                            the above, a Party may disclose details and information to its officers, employees, representatives
                                            or persons acting on its behalf, and Affiliates as necessary for the performance of its obligations
                                            pursuant to this Agreement and any SOW, provided that it procures that such parties execute
                                            a confidentiality agreement substantially similar in content to this section 5 or are bound
                                            by confidentiality undertakings which are not less stringent than those specified above.

 

		5.4.	Without
                                            prejudice to the foregoing, the Company shall not mention the names of HUJ, Yissum or the
                                            Researcher/s unless required by law or in connection with prosecuting or maintaining Patent(s),
                                            if applicable, or Research Results Patents, in any manner or for any purpose in connection
                                            with this Agreement or any matter relating to any Research Project, without obtaining the
                                            prior written consent of Yissum.

 

		5.5.	Without
                                            prejudice to the foregoing, HUJ, Yissum or the Researcher(s) shall not mention the name of
                                            the Company unless required by law or in connection with prosecuting or maintaining a Patent,
                                            if applicable, or Research Results Patents, in any manner or for any purpose in connection
                                            with this Agreement or any matter relating to a Research Project, without obtaining the prior
                                            written consent of the Company.

 

		5.6.	Each
                                            Party shall be fully accountable and responsible for actions of any of its officers, employees,
                                            representatives or persons acting on its behalf (including in the case of Yissum, the Researcher(s)_
                                            and any other employees of HUJ) which constitute a breach of this Section 5.

 

		5.7.	The
provisions of this section shall be subject to permitted publications pursuant to Section 6, below.

 

	6.	Publications

 

Yissum,
subsequent to the execution of any SOW associated with this Agreement, and until the expiration of the applicable Negotiations Period,shall
ensure that no publications in writing in scientific journals, or orally at scientific conventions, relating to a Research Project are
published by it or the Researcher(s) until Yissum, has taken the necessary steps to protect any patentable invention being disclosed
in such proposed publication, and subject to the prior written consent of the Company, such consent shall not be unreasonably withheld.
Following the expiration of the applicable Negotiations Period, the Researcher(s) will be permitted to publish information regarding
said Research Project provided that the Researcher(s) first submits the publication to the Company. The Company may reasonably withhold
its consent to such publication until the following remedies are met: (i) to delete Company-owned Confidential Information or (ii) to
delete information the publication of which may jeopardize the vital interest of the Company (provided that Company shall not be allowed
to object to accurate scientific findings only based on such interests) or (iii) to allow for the filing of patent applications or similar
intellectual property protection on any of the Company’s intellectual property that might appear in the proposed publication.
Notwithstanding the above, the Company’s consent may not be withheld for a period longer than 90 (ninety) days from the day that
the Researcher(s) first submitted the said publication to the Company, after which time the publication will be automatically permitted.
Without limiting the foregoing, it is agreed that to the extent a Research Project is not successful, such as, without limitation, it
cannot show any effects of the molecules on the profiles and purposes defined by the Parties.

 

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	7.	Disclaimer
                                            of Warranties and Liability

 

YISSUM
MAKES NO WARRANTIES OF ANY KIND WITH RESPECT TO ANY PATENT(S), IF APPLICABLE, OR RESEARCH PROJECTS. IN PARTICULAR, YISSUM MAKES NO WARRANTIES
THAT ANY RESULTS OR INVENTIONS WILL BE ACHIEVED BY ANY RESEARCH PROJECS, OR THAT PATENT(S), ASAPPLICABLE, OR THE RESEARCH RESULTS PATENTS,
IF ANY, ARE OR WILL BE COMMERCIALLY EXPLOITABLE OR THAT ANY PATENT(S), IF APPLICABLE, OR THE RESEARCH RESULTS PATENTS, IF ANY, WILL NOT
INFRINGE ANY PATENT, COPYRIGHT, TRADEMARK OR OTHER RIGHTS OF ANY THIRD PARTY. YISSUM SHALL HAVE NO LIABILITY WHATSOEVER TO THE COMPANY
OR TO ANY THIRD PARTY FOR OR ON ACCOUNT OF ANY INJURY, LOSS, OR DAMAGE, OF ANY KIND OR NATURE, SUSTAINED BY THE COMPANY OR BY ANY THIRD
PARTY, FOR ANY DAMAGE ASSESSED OR ASSERTED AGAINST THE COMPANY, OR FOR ANY OTHER LIABILITY INCURRED BY OR IMPOSED UPON THE COMPANY OR
ANY OTHER PERSON OR ENTITY, ARISING OUT OF OR IN CONNECTION WITH OR RESULTING FROM THE USE OF PATENT(S), AS APPLICABLE, OR THE RESEARCH
RESULTS.

 

	8.	Termination
                                            of the Agreement

 

		8.1.	Without prejudice to the Parties’ rights pursuant to
this Agreement or at law, each Party may terminate this Agreement, by written notice to the other Party in any of the following cases:

 

		8.1.1.	Immediately
                                            upon such written notice, if: (i) a Party passes a resolution for voluntary winding up or
                                            a winding up application is made against it and not set aside within 60 days; or (ii) a receiver
                                            or liquidator is appointed for a Party; or (iii)
a Party enters into winding up or insolvency or bankruptcy proceedings. The Parties undertake to notify the other Party within seven
days if any of the abovementioned events occur.

 

		8.1.2.	Upon
                                            breach of this Agreement, or of a SOW, where such breach has not been remedied within thirty
                                            (30) days from the breaching Party’s receipt of written notice of such breach. However, to
                                            the extent the breach of the Agreement relates only to one or more specific SOW, then only
                                            such specific SOW or SOW may be terminated under the terms of this Section 8.1.2, whereas
                                            any other SOW executed under this Agreement shall continue in full force and effect until
                                            expiration or termination under the terms of this Agreement and of each applicable SOW and,
                                            in such event, the terms of this Agreement shall continue to apply to such SOW until their
                                            expiration or termination. To the extent the breach applies to all the SOW executed hereunder,
                                            then all such SOW, and the Agreement, may be terminated under this Section 8.1.2.

 

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		8.2.	In
                                            addition to the above, and without prejudice to Yissum’s rights pursuant to this Agreement
                                            or at law, Yissum shall be entitled to terminate any SOW executed under this Agreement upon
                                            14 days prior written notice to the Company in the following circumstances:

 

		8.2.1.	Unauthorized
                                            early termination by the Company of the Research Program under the specific SOW, or failure
                                            to pay the applicable Research Fee due under such SOW, as set forth in Section 2.1. above;
                                            or

 

		8.2.2.	If
                                            an attachment is made over the Company’s assets or if execution proceedings are taken against
                                            the Company and the same are not set aside within 90 days of the date the attachment is made
                                            or the execution proceedings are taken. In such case, all the SOWs and this Agreement may
                                            be terminated.

 

		8.3.	The
                                            Company may terminate the Agreement, or any specific SOW executed under this Agreement, at
                                            any time upon forty-five (45) days prior written notice to Yissum, provided that the Company
                                            shall pay Yissum for tasks performed under the applicable SOWs until the effective date of
                                            termination and for those irrevocable commitments that were part of the applicable Research
                                            Budget(s) and entered into by Yissum prior to having received the Company’s written notice
                                            of termination.

 

		8.4.	The
                                            termination of this Agreement or any SOW hereunder for any reason shall not release the Company
                                            from its obligation to carry out any financial or other obligation which it was liable to
                                            perform prior to the Agreement’s, or applicable SOW’s, termination.

 

In
addition, Sections 5, 6, 7, 8.3, and 9 shall survive the termination of this Agreement to the extent required to effectuate the intent
of the parties as reflected in this Agreement.

 

	9.	Miscellaneous

 

		9.1	Governing
                                            Law and Jurisdiction. The provisions and interpretation of this Agreement and any SOW
                                            hereunder, all matters related to this Agreement and everything concerning the relationship
                                            between the Parties in accordance with this Agreement or any SOW executed hereunder shall
                                            be governed by Israeli law without application of any conflict of law rules. Any dispute
                                            arising from this Agreement or any SOW hereunder shall be submitted to the exclusive jurisdiction
                                            of the Courts in Jerusalem.

 

		9.2	Force
                                            Majeure. Neither Party shall be held liable or responsible to the other Party nor be
                                            deemed to have defaulted under or breached the Agreement, or any SOW hereunder, for failure
                                            or delay in fulfilling or performing any term of any SOW executed under this Agreement to
                                            the extent, and for so long as, such failure or delay is caused by or results from causes
                                            beyond the reasonable control of the affected Party and without fault of such Party, including,
                                            without limitation, fires, earthquakes, floods, embargoes, pandemics, epidemics, wars, acts
                                            of war (whether war is declared or not), insurrections, riots, civil commotions, strikes,
                                            lockouts or other labor disturbances (except of such Party’s personnel), acts of God, or
                                            acts, omissions or delays in acting by any governmental authority, provided that the nonperforming
                                            Party uses commercially reasonable efforts to avoid or remove such causes of nonperformance
                                            and continues performance under the applicable SOW executed under this Agreement with reasonable
                                            dispatch whenever such causes are removed. The Party affected by such circumstances shall
                                            promptly notify the other
Party in writing when such circumstances cause a delay or failure in performance and when they cease to do so.

 

		9.3	Agreements
                                            with the Researcher/s. The Company shall not enter into any new agreement or arrangement
                                            of any kind with a Researcher(s) without Yissum’s prior written consent.

 

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		9.4	Assignment.
                                            No Party may transfer or assign or endorse its rights, duties or obligations pursuant to
                                            this Agreement or any SOW hereunder to another, without the prior written consent of the
                                            other Party, which consent shall not be unreasonably denied, conditioned or delayed, except
                                            that the Company may assign this Agreement or any SOW hereunder to an Affiliate of Company
                                            without the need for a prior consent of Yissum, provided such Affiliate agrees in writing
                                            to be bound by the terms and conditions of this Agreement and the applicable SOW(s).

 

		9.5	Counterparts.
                                            This Agreement may be executed in any number of counterparts (including counterparts transmitted
                                            by facsimile and by electronic mail), each of which shall be deemed an original, but all
                                            of which taken together shall be deemed to constitute one and the same instrument.

 

		9.6	Binding
                                            Effect. This Agreement and the SOW executed hereunder shall be binding upon the Parties
                                            once executed by both Parties and shall enter into force and become effective as of the Effective
                                            Date.

 

		9.7	Entire
                                            Agreement. This Agreement and the SOW attached hereto constitute the full and complete
                                            agreement between the Parties and supersedes any and all agreements or understandings, whether
                                            written or oral, concerning the subject matter of this Agreement, and may only be amended
                                            by a document signed by both Parties. In the event of any contradiction between the terms
                                            of this Agreement or any SOW executed hereunder, the terms of this Agreement shall prevail,
                                            unless expressly agreed otherwise by the Parties as set forth in the applicable SOW.

 

	10.	Notices

 

All
notices and communications pursuant to this Agreement shall be made in writing and sent by facsimile or by registered mail or electronic
mail or served personally at the following addresses:

 

Yissum

Yissum
Research Development Company

of the Hebrew University of Jerusalem,

Hi-Tech Park, Edmond J. Safra Campus

Givat Ram, P.O. Box 39135,

Jerusalem
91390 Israel

Attention:
General Counsel

Email:
generalcounsel@yissum.co.il

 

The
Company

 

Clearmind
Medicine Ltd. 20 Raoul Valenberg ST

Tel Aviv 6971916

 

Israel

Attention:
CEO ( Dr. Adi Zuloff Shani)

Email:
adi@clearmindmedicine.com

 

or
such other address furnished in writing by one Party to the other. Any notice served personally or by electronic mail shall be deemed
to have been received on the day of service. Any notice sent by prepaid registered mail shall be deemed to have been received seven days
after being posted.

 

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IN
WITNESS THE HANDS OF THE PARTIES

 

	YISSUM	 	THE COMPANY
	 	 	 	 	 
	By:	/s/ Ilya Pittel	 	By:	/s/ Dr. Adi Zuloff-Shani
	Name: 	Ilya Pittel	 	Name: 	Dr. Adi Zuloff-Shani
	Title:	VP of BD AgTech, FoodTech, Veterinary and Environmental	 	Title:	Chief Executive

 

 

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Appendix
A

Unless
otherwise set forth in an applicable SOW, the commercial terms of the License shall be as follows:

 

Commercial
Terms

 

	Consideration	Fee	Timing
    or Special Condition
	Annual
    License Maintenance Fee	Year
                                            0: $0

    Year
    2-3: $0

    Year
    4-6: $25,000

    Year
    7-8: $35.000

    Year
    9 and on: $50,000
	Creditable
    against Royalties in same year
	Royalty
                                                                                                                                                      on Net Sales (from commercialization of products or outcomes of the Targeted Business Activity) (as defined below)
	3%	Pass-Through
    (Flat) on sales by the Company, an Affiliate or a Sublicensee.
	Sublicense
                                            Considerations (not Exit Event related, and non-sales- related consideration); e.g. sublicense
                                            fee, maintenance fees, milestone payments, etc. of the technology of the Targeted Business
                                            Activity

    (as
    defined below)
	20%	From
    Sublicensee
	Milestone
    Payments	●    
                                                                                                                        $400,000 Upon first patient enrolled in a Phase III Clinical Trial

    ●     
    $600,000 Upon First Commercial Sale in the US or EU
	 
	Exit
    Fee	1.
                                                                                                                        Upon an Exit Event that encompasses the Targeted Business Activity (as defined below) – an Exit Fee of 1 % of the Exit
                                                                                                                        Proceeds associated with the Ratio Value of the Targeted Business Activity.

    For
    the purpose hereof, “Targeted Business Activity” means the business activity of developing and commercializing
    of the Research Results, including without limitation the Research Results Patents.

     

    “Ratio
    Value” means the value of the Targeted Business Activity out of the overall value of the entire business activity which
    is the subject matter of the Exit Event, as shall be determined by third party expert appraiser to be agreed upon by the Parties,
    at the Company’s expense.

     

    
	 

 

    11

     

    

 

 

	Consideration	Fee	Timing
    or Special Condition

	 	By
way of example only, (i) if the Ratio Value of the Targeted Business Activity is 20% (of the overall value of the entire business activity
which is the subject matter of the Exit Event) then Yissum shall be entitled to receive 1% of 20% of the Exit Proceeds, i.e. 0.2% of
the Exit Proceeds: (ii) If the Ratio Value of the Targeted Business Activity is 10%, then Yissum
                                            shall be entitled to 1% of the 10% if the Exit Proceeds, i.e. 0.1% of the Exit Proceeds;
                                            (iii) If the Exit Event is of a Targeted Company (as defined in the Agreement) engaging only
                                            in the Targeted Business Activity, then the Value is 100% and Yissum shall be entitled
                                            to 1% of the Exit Fee.

                                                                                                                                                                  

    2.
    If an Exit Event that encompasses the Targeted Business Activity does not occur within ten (10) years from the execution of a
    License Agreement, then the Company’s parent, Clearmind Medicine Inc (“Parent”) shall issue to Yissum such number
    of common shares of the Parent, constituting 1% of the Ratio Value of the Targeted Business Activity (out of the overall market
    value of the Parent).

     

    By
    way of example only, if the Ratio Value of the Targeted Business Activity is 20% then Yissum shall be entitled to receive such number
    of Parent’s shares constituting 0.2% of the Parent’s stock capital on a fully diluted basis.
	 
	Patent
    Expenses	Past
    and Ongoing	As
    may be indicated in the applicable SOW.

 

The
terms “Net Sales”, “Sublicense Consideration “shall be defined in the License Agreement.

 

 

12Exhibit 10.4

 

Framework Agreement for the
Conduct of Research

 

This Framework Agreement for the Conduct
of Research (“Agreement”) is made in Jerusalem this 31st day of July, 2022, and shall be effective retroactively
as of the 8th day of November, 2021 (the “Effective Date”), by and between:

 

YISSUM
RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD., of Hi Tech Park, Edmond J. Safra Campus, Givat Ram,
Jerusalem 91390, Israel (“Yissum”) of the first part; and

 

CLEARMIND MED Ltd., of 20 Raoul
Wallenberg St. Tel-Aviv; on behalf of itself and its Affiliates (the "Company"), of the second part;

 

(each of Yissum and the Company, a “Party”,
and collectively the “Parties”)

 

Yissum and the Company hereby agree
to all the following terms and conditions:

 

		1.	The Research. The Company may request from time to time that certain
research services be performed via Yissum in accordance with one or more statement of work orders (the “Research Project”
and the “SOW”, respectively). The objectives and specifications of each Research Project shall be detailed in the applicable
SOW, which shall constitute an integral part of this Agreement. For the purpose of this Agreement, “SOW”
shall mean a statement of work, to which the Parties may enter form time to time, which is duly executed by the Parties, and which shall
define: (i) the program under which the Research Project shall be funded by the Company and conducted by the Researcher/s, (ii) the Company
Molecules, if any, (iii) the Company Patents, if any, associated with the Research Program, (iv) the applicable Research Period, (v) the
Milestones (as defined blow), if any, and (vi) the corresponding Research Fee (all capitalized terms – as defined herein).

 

		2.	Time Schedule: Each Research Project is to be performed in accordance with the time schedule to
be set forth in the applicable SOW (the “Research Period”).

 

		3.	Company Molecules: The Company’s proprietary molecules described in the applicable SOW, if
any, (the “Company’s Molecules”) based on the Company’s Patents.

 

		4.	Company’s Patents: Patents of the Company listed in the applicable SOW.

 

		5.	The Researcher: With respect to each Research Project, the researcher/s
appointed by Yissum to supervise and to perform the Research Project contemplated under such SOW.

 

		6.	The Scientific Report: The scientific report that will be required as a result of any Research
Project rendered will be presented directly to the Company by the Researcher/s within 14 (fourteen) days of the end of each Research Period
(the “Scientific Report”). In addition, the Researcher/s shall provide the Company with a periodic report within 30
(thirty) days of reaching each milestone identified in the applicable SOW (a "Milestone"), if any, and the Researcher/s
and the Company shall telephonically conduct a joint review of the Research Project every other month during the Research Period, unless
otherwise agreed in the SOW. The Company acknowledges that no financial report will be given by Yissum or the Researcher.

 

		7.	The Consideration: In consideration for provision of any Research Project in its entirety and the
Scientific Report (including also the periodical Milestone reports), the Company shall pay Yissum the total sum as shall be set forth
in each SOW (the “Research Fee”). The specific budget items per each phase of a Research Project that make up the Research
Fee are detailed in the applicable SOW and constitute an integral part of this Agreement. Because the allocation of expenses in the budget
is based on expected expense categories and an expected allocation of specific expenses within each category, such categories and the
allocation of expenses among the various expense categories may be modified by the Researcher/s where reasonably necessary or appropriate
during the Research Period, it being agreed, however that the aggregate Research Fee shall not be increased without the written consent
of the Company. Any such modifications shall be agreed in writing as an amendment to the applicable SOW.

 

The Company shall pay the Research Fee in accordance with
the schedule set forth in the applicable SOW.

 

     

     

    

 

The commencement of any Research Project
shall be conditioned upon receipt by Yissum of the first payment set forth in the applicable SOW.

 

Payment shall be made upon the presentation
of an invoice. Payments may be made by check or by wire transfer to the following account:

 

Name of Bank: *****

Bank Key: *****

Bank's address: *****

Branch: *****

Bank account Number: *****

Swift Code: *****

IBAN: *****

 

The Company shall always use the payment
information provided above. The Company shall not accept any changes in respect of the payment route or bank account details that are
received via email, facsimile or by other means of communication, including, without limitation, any invoice or other written request
for payment, unless such changes are set forth in an amendment to this Agreement, on the letterhead of Yissum signed by its Chief Financial
Officer or Controller. If the Company breaches this provision, it shall bear any financial loss or other consequences arising therefrom
and shall indemnify Yissum for any such loss or damages that may be incurred by Yissum.

 

		8.	Intellectual Property: It is hereby agreed that the Company retains ownership in its Confidential
Information (as defined below), and in all its intellectual property rights related thereto. In addition, any intellectual property belonging
to either the Company or Yissum prior to the execution of this Agreement or any SOW hereunder will remain the sole property of either
the Company or Yissum, respectively. For the avoidance of doubt, the Company
solely owns intellectual property, including, without limitation, the Company Patents, as defined under the applicable SOW, if applicable
(including patent applications, provisional applications and all derivatives thereof) and know-how of the Company in connection with the
Company’s Molecules, as defined under the applicable SOW, if applicable, belonging to the Company prior to the execution of any
Research Project or developed outside the scope of any Research Project, in the indication which is the subject matter of the Research
Project. The Company shall grant Yissum a non-exclusive, non-transferable, non-sublicensable right and license under Company’s Patents
and other intellectual property rights associated therewith, as may be required to conduct and perform a specific Research Project, as
shall be set forth in the applicable SOW.

 

All results and outcomes, including
without limitation, data and materials, generated from the provision of any Research Project, including the Scientific Report, which are
specifically required and contemplated under any SOW (the “Company Data”), shall be solely owned by the Company subject
to full payment of the Research Fee.

 

It is hereby clarified that neither
the conduct of any Research Project under this Agreement or any SOW hereunder nor the results of any Research Project are required or
expected to result in any patentable invention related to the Company Data on which the Researcher/s would be considered an inventor.
Notwithstanding the foregoing, to the extent the results of a Research Project include such intellectual property that is patentable such
patentable results of the Research Project shall be jointly owned by the Parties (“Joint Patent(s)”). It is understood
and agreed that the Company shall have an option to obtain exclusive rights to use Yissum’s ownership rights in the Joint Patent(s).
The commercial terms of such an exclusive license, as well as the terms of filing and maintaining the Joint Patent(s), shall be negotiated
in good faith by the Parties.

 

		9.	Confidentiality: Yissum and the Researcher/s agree to maintain the confidentiality of any information
disclosed to them by the Company in connection with each Research Project, which the Company identifies as confidential at the time of
disclosure (“Confidential Information”), and not to make public any such Confidential Information without the prior
written permission of the Company. This undertaking shall not apply to Confidential Information that is in the public domain at the time
of disclosure or thereafter enters the public domain through no fault of Yissum or the Researcher/s or that the Researcher/s can show,
by contemporaneous written evidence, was already known to such Researcher/s at the time of disclosure; or that is provided to Yissum or
the Researcher/s by a third party having no obligations of confidentiality to the Company; or that is independently developed by an employee
of the University who is not the Researcher/s. In addition, Yissum or the Researcher/s shall be entitled to disclose Confidential Information
pursuant to a valid judicial or administrative order, provided that they shall provide prompt notice to the Company of their receipt of
such an order to allow the Company to seek relief against such order.

 

    2

     

    

 

		10.	Publications: The Researcher/s will be permitted to publish information regarding the applicable
technical work connected to such Research Project provided that the Researcher/s first submits the publication to the Company. The Company
may reasonably withhold its consent to such publication (i) to delete Company-owned Confidential Information or (ii) to delete information
the publication of which may jeopardize the vital interest of the Company (provided that Company shall not be allowed to object to accurate
scientific findings only based on such interests) or (iii) to allow for the filing of patent applications or similar intellectual property
protection on any of the Company’s intellectual property that might appear in the proposed publication, provided however that such
Company consent may not be withheld for a period longer than 90 (ninety) days from the day that the Researcher/s first submitted the said
publication to the Company, after which time the publication will be automatically permitted. Without limiting the foregoing, it is agreed
that to the extent that a Research Project is not successful, the Researcher/s shall not publish such information.

 

		11.	Use of Names: Neither Party shall make any use of any kind of the name of the other Party, the
Researcher/s and/or the Hebrew University of Jerusalem (the “University”) without the prior written consent of the
other Party, which consent shall not be unreasonably withheld.

 

		12.	Relationship of the Parties: The Parties do not stand in a relationship of employer-employee. The
relationship between the Parties shall be that of requester – independent contractor.

 

		13.	Dispute Resolution: The provisions and interpretation of this
Agreement and any SOW hereunder, all matters related to this Agreement and everything concerning the relationship between the Parties
in accordance with this Agreement and/or any SOW executed hereunder shall be governed by Israeli law without application of any conflict
of law rules. Any dispute arising from this Agreement and/or any SOW hereunder shall be submitted to the exclusive jurisdiction of the
Courts in Jerusalem.

 

		14.	Disclaimer of Warranty, Liability and Indemnification:

 

		(a)	Nothing contained in this Agreement shall be construed as
a warranty on the part of Yissum or the University that any results or inventions will be achieved by any Research Project, or that the
results of any Research Project, if any, are or will be of commercial or scientific value to the Company.

 

		(b)	Yissum and the University, and their respective parents,
affiliates, officers, directors, employees, researchers (including, the Researcher/s), agents and contractors, (collectively, the “Indemnitees”),
shall not be liable for any claims, actions, demands, losses, damages, costs and expenses (including, without limitation, legal fees
and litigation costs) (collectively, “Claims”) made, brought or suffered by the Company or by any third parties arising
from any exploitation or use of the results of any Research Project (including, without limitation, any Company Data).

 

		(c)	In the event of any third party Claims are brought against
any of the Indemnitees as set out above, the Company shall indemnify, defend and hold harmless the relevant Indemnitees from and against
any and all such damages, liability, losses, costs and/or expenses.

 

		15.	Termination:

 

		(a)	This Agreement shall enter into force on the Effective Date
and shall remain in force until and unless terminated in accordance with the provisions of this Section 15.

 

		(b)	The Company may terminate this
Agreement, or any applicable SOW, at any time upon forty-five (45) days prior written notice to
Yissum provided that no monies paid to Yissum for the applicable Research Project pursuant to the schedule set forth in the applicable
SOW will be refundable; and (ii) the Company shall be responsible for the payment of any accrued fees and expenses due to Yissum based
on work duly performed up to the date of termination and those irrevocable commitments that were part of the applicable Research Project
budget and entered into by Yissum prior to having received the Company's written notice of termination the Company.

 

    3

     

    

 

		(c)	Each Party shall be entitled
to terminate this Agreement, or any applicable SOW, in the event of a breach by the other Party
of its obligations under this Agreement, or any applicable SOW, including, but not limited to, any
payment failure, which is not remedied by the breaching Party within 30 (thirty) days of receipt of written notice from the non-breaching
Party. However, to the extent the breach of the Agreement relates only to one or more specific SOWs, then only such specific SOW
or SOWs may be terminated under the terms of this Section 15, whereas any other SOWs executed under this Agreement shall continue in
full force and effect until expiration or termination under the terms of this Agreement and of each applicable SOW and, in such event,
the terms of this Agreement shall continue to apply to such SOWs until their expiration or termination. To the extent the breach applies
to all the SOWs executed hereunder, then all such SOWs, and the Agreement, may be terminated under this Section 15(c).

 

		(d)	If the Agreement, or
any applicable SOW, is terminated prior to the end of the applicable Research Period, all amounts paid
under this Agreement, or any applicable SOW, up to the date of termination shall be considered as
non-refundable.

 

		(e)	Sections 6, 7, 8, 9, 13, 14 and 15 shall survive termination
of this Agreement.

 

		16.	Force Majeure: Neither Party shall be held liable or
responsible to the other Party nor be deemed to have defaulted under or breached the Agreement for failure or delay in fulfilling or
performing any term of this Agreement, or any SOW hereunder, to the extent, and for so long as, such failure or delay is caused by or
results from causes beyond the reasonable control of the affected Party and without fault of such Party, including, without limitation,
fires, earthquakes, floods, embargoes, pandemics, epidemics, wars, acts of war (whether war is declared or not), insurrections, riots,
civil commotions, strikes, lockouts or other labor disturbances (except of such Party's personnel), acts of God, or acts, omissions or
delays in acting by any governmental authority, provided that the nonperforming Party uses commercially reasonable efforts to avoid or
remove such causes of nonperformance and continues performance under this the applicable SOW executed under Agreement with reasonable
dispatch whenever such causes are removed. The Party affected by such circumstances shall promptly notify the other Party in writing
when such circumstances cause a delay or failure in performance and when they cease to do so.

 

		17.	Assignment: No Party may transfer or assign or endorse its rights, duties or obligations pursuant
to this Agreement or any SOW hereunder to a third party, without the prior written consent of the other Party, which consent shall not
be unreasonably denied, conditioned or delayed, except that the Company may assign this Agreement or any SOW hereunder to an Affiliate
of Company as defined below, without the need for a prior consent of Yissum, provided such Affiliate agrees in writing to be bound by
the terms and conditions of this Agreement and the applicable SOW(s). For the purpose of this Agreement, an Affiliate shall include Company’s
parent company Clearmind Medicine Inc. (“Parent”) or any subsidiary in which the Company maintains control of the affairs
of such subsidiary, or any affiliate which is under the control of the Parent, or under the common control of the Company or the Parent;
where control means the holding of more than 50% of the issued and outstanding shares of the Company or of the voting rights in an entity.

 

		18.	Binding Effect: This Agreement and any SOW hereunder shall be binding upon the Parties once executed
by the authorized signatories of both Parties and shall enter into force and become effective as of the Effective Date. Each Party warrants
that the person or persons signing this Agreement is/are authorized to bind that Party.

 

		19.	Entire Agreement: This Agreement and any SOW hereunder constitutes the full and complete agreement
between the Parties and supersedes any and all agreements or understandings, whether written or oral, concerning the subject matter of
this Agreement and any SOW hereunder, and may only be amended by a document signed by both Parties.

 

		20.	Notices: Any notice or communication sent by either a Party to the other Party pursuant to this
Agreement shall be in writing and shall for all purposes be deemed to be fully given and received on the first business day on or after
which it is received by personal delivery, prepaid registered airmail, return receipt requested, or facsimile or electronic mail (with
confirmation of receipt), addressed to the Party to be notified at the address of such Party as set forth below.

 

		21.	Counterparts: This Agreement and any SOW hereunder may be executed in any number of counterparts
(including counterparts transmitted by facsimile and by electronic mail), each of which shall be deemed an original, but all of which
taken together shall be deemed to constitute one and the same instrument.

 

{Signature Page Follows}

 

    4

     

    

 

IN
WITNESS THE HANDS OF THE PARTIES

 

	Clearmind Med
    Ltd.	 	Yissum Research
    Development Company of the
	20 Raoul Wallenberg St.	 	Hebrew University of Jerusalem
    Ltd.
	Tel Aviv 6971916	 	Hi-Tech Park, Edmond J. Safra
    Campus,
	Israel	 	Givat Ram, P.O.B 39135, Jerusalem
    91390, Israel
	Attention: Dr. Adi Zuloff
    Shani, CEO	 	Email: generalcounsel@yissum.co.il
	Email: adi@clearmindmedicine.com	 	 

 

	By:
    	/s/
    Dr. Adi Zuloff-Shani	 	By:
    	/s/
    Ilya Pittel 	and	/s/
    Dr. Itzik Goldwasser
	Name: 
    	Dr.
    Adi Zuloff-Shani 	 	Name: 
    	Ilya Pittel	 	Dr.
    Itzik Goldwasser
	Title:
    	CEO	 	Title:	VP of
    BD AgTech, FoodTech, Veterinary and Environmental	 	Chief
    Executive Officer

 

 

5

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