Document:

EX-4.1

 Exhibit 4.1 
 EXECUTION COPY 
 FOURTH AMENDED AND RESTATED 

REGISTRATION RIGHTS AGREEMENT 
 by and among 
 MACROGENICS, INC., 

THE FOUNDERS, 

and 
 THE
INVESTORS 
 September 19, 2008 

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
		
	 1.      Certain Definitions
	  	 	1	  
		
	 2.      Restrictive Legend
	  	 	2	  
		
	 3.      Notice of Proposed Transfer
	  	 	2	  
		
	 4.      Required Registration
	  	 	3	  
		
	 5.      Incidental Registration
	  	 	4	  
		
	 6.      Registration on Form S-3
	  	 	5	  
		
	 7.      Registration Procedures
	  	 	6	  
		
	 8.      Expenses
	  	 	8	  
		
	 9.      Indemnification and Contribution
	  	 	8	  
		
	 10.    Changes in Common Stock or Preferred Stock
	  	 	10	  
		
	 11.    Rule 144 Reporting
	  	 	10	  
		
	 12.    Representations and Warranties of the Company
	  	 	11	  
		
	 13.    Binding Arbitration
	  	 	11	  
		
	 14.    Miscellaneous
	  	 	13	  

  
 i 

 MACROGENICS, INC. 

FOURTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 
 THIS FOURTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT, dated September 19, 2008 (this “Agreement”), is made by and among MacroGenics, Inc., a Delaware corporation (the
“Company”), those parties identified as Founders on the signature page hereto (the “Founders”), the parties listed on Exhibit A hereto (the “Existing Investors”), the parties listed on
Exhibit B hereto (the “Series D Investors”), and the parties executing the signature pages hereto (the “New Investors,” and collectively with the Existing Investors and the Series D Investors, the
“Investors”). 
 In consideration of the mutual promises and obligations contained herein, the parties hereto
agree as follows: 
 1. Certain Definitions. As used in this Agreement, the following terms shall have the following
respective meanings: 
 “Additional Restricted Stock” shall mean the shares of Common Stock (the
“Additional Conversion Shares”) issued upon conversion of the 5,000,000 Preferred Shares (the “Additional Preferred Stock”) issued and sold pursuant to that certain Stock Purchase Agreement dated as of
October 27, 2003, by and between the Company and Genzyme Corporation, excluding Additional Conversion Shares which have been (a) registered under the Securities Act pursuant to an effective registration statement filed thereunder and
disposed of in accordance with the registration statement covering them or (b) publicly sold pursuant to Rule 144 under the Securities Act. 
 “Commission” shall mean the Securities and Exchange Commission, or any other federal agency at the time administering the Securities Act. 

“Common Stock” shall mean the Common Stock, $0.01 par value per share, of the Company, as constituted as of the date of
this Agreement. 
 “Conversion Shares” shall mean shares of Common Stock issued upon conversion of the
Preferred Shares. 
 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, or any similar
federal statute, and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time. 

“Preferred Shares” shall mean the shares of Series A-1 Convertible Preferred Stock, $0.01 par value per share, the
shares of Series A-2 Convertible Preferred Stock, $0.01 par value per share, the shares of Series B-1 Convertible Preferred Stock, par value $0.01 per share, the shares of Series C Convertible Preferred Stock, $0.01 par value per share, the shares
of Series D Convertible Preferred Stock, $0.01 par value per share, and the shares of Series D-2 Convertible Preferred Stock, $0.01 par value per share. 

  
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 “Preferred Stock” shall mean the Series A-1 Convertible Preferred Stock,
$0.01 par value per share, the Series A-2 Convertible Preferred Stock, $0.01 par value per share, the Series B-1 Convertible Preferred Stock, par value $0.01 per share, the Series C Convertible Preferred Stock, $0.01 par value per share, the Series
D Convertible Preferred Stock, $0.01 par value per share, and the Series D-2 Convertible Preferred Stock, $0.01 par value per share. 
 “Registration Expenses” shall mean the expenses so described in Section 8. 
 “Restricted Stock” shall mean the Conversion Shares, excluding (i) Additional Conversion Shares and (ii) Conversion Shares which have been (a) registered under the
Securities Act pursuant to an effective registration statement filed thereunder and disposed of in accordance with the registration statement covering them or (b) sold pursuant to Rule 144 under the Securities Act. For purposes of
Section 5 hereof, and all other provisions of this Agreement applicable to any registration covered by Section 5 hereof, Restricted Stock shall also include all Common Stock then held by the Founders and the University. 

“Securities Act” shall mean the Securities Act of 1933, as amended, or any similar federal statute, and the rules and
regulations of the Commission thereunder, all as the same shall be in effect at the time. 
 “Selling Expenses”
shall mean the expenses so described in Section 8. 
 “University” shall mean the Board of Regents of the
University of Texas System. 
 2. Restrictive Legend. Each certificate representing Preferred Shares or Conversion Shares
shall, except as otherwise provided in this Section 2 or in Section 3, be stamped or otherwise imprinted with a legend substantially in the following form: 
 “THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE OFFERED, SOLD OR
OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT AND IN COMPLIANCE WITH SUCH STATE SECURITIES LAWS OR UNLESS THE ISSUER HAS RECEIVED OR WAIVED AN OPINION OF LEGAL COUNSEL SATISFACTORY TO THE ISSUER
AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED AND SUCH COMPLIANCE IS AVAILABLE.” 
 A certificate shall not bear such legend if in
the opinion of counsel reasonably satisfactory to the Company the securities represented thereby may be publicly sold without registration under the Securities Act and any applicable state securities laws. 

3. Notice of Proposed Transfer. Prior to any proposed transfer of any Preferred Shares or Conversion Shares (other than under the
circumstances described in Sections 4, 5 or 6), the holder thereof shall give written notice to the Company of its intention to effect such transfer. Each such notice shall describe the manner of the proposed transfer and, if requested by the
Company, shall be accompanied by an opinion of counsel reasonably satisfactory to the Company to the effect that the proposed transfer may be effected without registration under the 

  
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Securities Act and any applicable state securities laws, whereupon the holder of such stock shall be entitled to transfer such stock in accordance with the terms of its notice; provided,
however, that no such opinion of counsel shall be required for (i) a transfer to one or more partners or members of the transferor (in the case of a transferor that is a partnership or a limited liability company, respectively) or to an
affiliated corporation (in the case of a transferor that is a corporation) or (ii) a transfer by any Investor to an affiliate or an entity controlled by, controlling or under common control with such Investor. Each certificate for Preferred
Shares or Conversion Shares transferred as above provided shall bear the legend set forth in Section 2, except that such certificate shall not bear such legend if (A) such transfer is in accordance with the provisions of Rule 144 (or any
other rule permitting public sale without registration under the Securities Act) or (B) the opinion of counsel referred to above is to the further effect that the transferee and any subsequent transferee (other than an affiliate of the Company)
would be entitled to transfer such securities in a public sale without registration under the Securities Act. The restrictions provided for in this Section 3 shall not apply to securities which are not required to bear the legend prescribed by
Section 2 in accordance with the provisions of that Section. 
 4. Required Registration 

(a) At any time after the earliest of (i) 180 days after any registration statement covering a public offering
of securities of the Company under the Securities Act shall have become effective, (ii) 180 days after the Company shall have become a reporting company under Section 12 of the Exchange Act, and (iii) the second (2nd) anniversary of May 16, 2006, the holders of Restricted
Stock (other than the New Investors and the Series D Investors) constituting at least 40% of the total shares of Restricted Stock then outstanding (other than the shares of Restricted Stock held by the New Investors and the Series D Investors) may
request the Company to register under the Securities Act all or any portion of the shares of Restricted Stock held by such requesting holder or holders for sale in the manner specified in such notice, provided that the reasonably anticipated
aggregate price to the public of such public offering would exceed $5,000,000. 
 (b) At any time after the
earliest of (i) 180 days after any registration statement covering a public offering of securities of the Company under the Securities Act shall have become effective, (ii) 180 days after the Company shall have become a reporting company
under Section 12 of the Exchange Act, and (iii) the second (2nd) anniversary of July 15, 2008, New Investors and Series D Investors constituting at least 40% of the total shares of Restricted Stock then collectively held by the New Investors and the Series
D Investors, may request the Company to register under the Securities Act all or any portion of the shares of Restricted Stock held by such requesting holder or holders for sale in the manner specified in such notice, provided that the
reasonably anticipated aggregate price to the public of such public offering would exceed $25,000,000. 
 (c) For purposes of
this Section 4 and Sections 5, 6, 13(a) and 13(d), the term “Restricted Stock” shall be deemed to include the number of shares of Restricted Stock that would be issuable to a holder of Preferred Shares upon conversion of all Preferred
Shares held by such holder at such time; provided, however, that the only securities which the Company shall be required to register pursuant hereto shall be shares of Common Stock, and provided, further, however,
that, in any underwritten public offering contemplated by this Section 4 or Sections 5 

  
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and 6, the holders of Preferred Shares shall be entitled to sell such Preferred Shares to the underwriters for conversion and sale of the shares of Common Stock issued upon conversion thereof.
Notwithstanding anything to the contrary contained herein, the Company shall not be obligated under this Section 4: (i) within 180 days after the effective date of a registration statement filed by the Company in connection with the
Company’s initial public offering, or (ii) within 180 days after the effective date of a registration statement filed by the Company covering a firm commitment underwritten public offering in which the holders of Restricted Stock shall
have been entitled to join pursuant to Section 5 or 6 and in which there shall have been effectively registered all shares of Restricted Stock as to which registration shall have been requested. 

(d) Following receipt of any notice under this Section 4, the Company shall immediately notify all holders of Restricted Stock and
Additional Restricted Stock from whom notice has not been received and shall use its best efforts to register under the Securities Act, for public sale in accordance with the method of disposition specified in such notice from requesting holders,
the number of shares of Restricted Stock and Additional Restricted Stock specified in such notice (and in all notices received by the Company from other holders within 30 days after the giving of such notice by the Company). If such method of
disposition shall be an underwritten public offering, the Company may designate the managing underwriter of such offering, subject to the approval of the holders of a majority of the shares of Restricted Stock to be sold in such offering, which
approval shall not be unreasonably withheld or delayed. The Company shall be obligated to register Restricted Stock and Additional Restricted Stock pursuant to this Section 4 on one (1) occasion only; provided, however, that
such obligation shall be deemed satisfied only when a registration statement covering all shares of Restricted Stock and Additional Restricted Stock specified in notices received as aforesaid, for sale in accordance with the method of disposition
specified by the requesting holders, shall have become effective and, if such method of disposition is a firm commitment underwritten public offering, all such shares shall have been sold pursuant thereto. Notwithstanding the foregoing, the Company
may delay a request for registration pursuant to this Section 4 if, within 30 days following the receipt of any notice requesting registration in accordance with this Section 4, the Company notifies the holders of Restricted Stock and
Additional Restricted Stock that the Company intends to file a registration statement with the Commission relating to an initial public offering within 90 days of such notice by the Company to the holders of Restricted Stock and Additional
Restricted Stock and provided the Company shall, in good faith, use reasonable efforts to cause such registration statement to become effective; provided, however, that the Company may exercise such right to delay a request for
registration under such circumstances not more than once in any 12-month period. 
 (e) The Company shall be entitled to include
in any registration statement referred to in this Section 4, for sale in accordance with the method of disposition specified by the requesting holders, shares of Common Stock to be sold by the Company for its own account, except as and to the
extent that, in the opinion of the managing underwriter (if such method of disposition shall be an underwritten public offering), such inclusion would adversely affect the marketing of the Restricted Stock and Additional Restricted Stock to be sold.

 5. Incidental Registration. If the Company at any time proposes to register any of its securities under the Securities
Act for sale to the public, whether for its own account or for the 

  
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account of other security holders or both (except with respect to registration statements on Forms S-4, S-8 or another form not available for registering the Restricted Stock or Additional
Restricted Stock for sale to the public), each such time it will give written notice to all holders of outstanding Restricted Stock and Additional Restricted Stock of its intention so to do. Upon the written request of any such holder, received by
the Company within 30 days after the giving of any such notice by the Company, to register any of its Restricted Stock or Additional Restricted Stock, the Company shall cause the Restricted Stock and Additional Restricted Stock as to which
registration shall have been so requested to be included in the securities to be covered by the registration statement proposed to be filed by the Company, all to the extent requisite to permit the sale or other disposition by the holder of such
Restricted Stock or Additional Restricted Stock so registered. In the event that any registration pursuant to this Section 5 shall be, in whole or in part, an underwritten public offering of Common Stock, the number of shares of Restricted
Stock and Additional Restricted Stock to be included in such an underwriting may be reduced if and to the extent that the managing underwriter shall be of the opinion that such inclusion would adversely affect the marketing of the securities to be
sold by the Company therein, provided, however, that such number of shares of Restricted Stock and Additional Restricted Stock shall not be reduced if any shares are to be included in such underwriting for the account of any person
other than the Company or holders of Restricted Stock or holders of Additional Restricted Stock, and provided, further, however, that, except in the case of the Company’s initial public offering, in no event may less than
twenty-five percent (25%) of the total number of shares of Common Stock to be included in such underwriting be made available for shares of Restricted Stock. In the event of such reduction, the Company shall so advise all holders of Restricted
Stock and Additional Restricted Stock requesting registration, and the number of shares that are entitled to be included in the registration and underwriting shall be allocated in the following manner. First, the number of shares that may be
included in such registration and underwriting shall be allocated among all Investors who have requested registration in proportion, as nearly as practicable, to the respective number of shares of Restricted Stock and Additional Restricted Stock
held by such Investors at the time of the Company’s notice under this Section 5. No shareholder of the Company shall be granted registration rights which would reduce the number of shares includable by the holders of the Restricted Stock
and Additional Restricted Stock in such registration without the consent of the holders of at least two-thirds of the Restricted Stock and Additional Restricted Stock. If any Investor would thus be entitled to include more securities than such
Investor requested to be registered, the excess shall be allocated among the other requesting Investors pro rata in the manner described in the preceding sentence. Second, once all shares of Restricted Stock and Additional Restricted Stock
requested by the Investors to be registered have been included in such registration and underwriting, the Founders and the University shall participate in the offering, pro rata based upon their total ownership of shares of Restricted Stock.
Notwithstanding the foregoing provisions, the Company may withdraw any registration statement referred to in this Section 5 without thereby incurring any liability to the holders of Restricted Stock or Additional Restricted Stock. 

6. Registration on Form S-3. If at any time (a)(i) a holder or holders of Restricted Stock (other than the Series D Investors)
request that the Company file a registration statement on Form S-3 or any successor thereto for a public offering of all or any portion of the shares of Restricted Stock held by such requesting holder or holders, the reasonably anticipated aggregate
price to the public of which would exceed $1,000,000; or (ii) one or more of the Series D 

  
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Investors request that the Company file a registration statement on Form S-3 or any successor thereto for a public offering of all or any portion of the shares of Restricted Stock held by such
requesting holder or holders, the reasonably anticipated aggregate price to the public of which would exceed $5,000,000; and (b) the Company is a registrant entitled to use Form S-3 or any successor thereto to register such shares, then
the Company shall use its best efforts to register under the Securities Act on Form S-3 or any successor thereto, for public sale in accordance with the method of disposition specified in such notice, the number of shares of Restricted Stock
specified in such notice. Whenever the Company is required by this Section 6 to use its best efforts to effect the registration of Restricted Stock, each of the procedures and requirements of Section 4 (including, but not limited to, the
requirement that the Company notify all holders of Restricted Stock and Additional Restricted Stock from whom notice has not been received and provide them with the opportunity to participate in the offering) shall apply to such registration;
provided, however, that the requirements contained in Section 4(a) and Section 4(b) shall not apply to any registration on Form S-3 which may be requested and obtained under this Section 6. 

7. Registration Procedures. If and whenever the Company is required by the provisions of Sections 4, 5 or 6 to use its best
efforts to effect the registration of any shares of Restricted Stock and/or Additional Restricted Stock under the Securities Act, the Company will, as expeditiously as possible: 

(a) prepare and file (in the case of a registration pursuant to Section 4 or Section 6, within 60 days of receipt by the
Company of the applicable request for registration) with the Commission a registration statement (which, in the case of an underwritten public offering pursuant to Section 4, shall be on Form S-1 or other form of general applicability
satisfactory to the managing underwriter selected as therein provided) with respect to such securities and use its best efforts to cause such registration statement to become and remain effective for the period of the distribution contemplated
thereby (determined as hereinafter provided); 
 (b) prepare and file with the Commission such amendments and supplements to
such registration statement and the prospectus used in connection therewith as may be necessary to keep such registration statement effective for the period specified in subparagraph (a) above and comply with the provisions of the Securities
Act (including the antifraud provisions thereof) with respect to the disposition of all Restricted Stock and Additional Restricted Stock covered by such registration statement in accordance with the sellers’ intended method of disposition set
forth in such registration statement for such period; 
 (c) furnish to each seller of Restricted Stock and Additional
Restricted Stock and to each underwriter such number of copies of the registration statement and the prospectus included therein (including each preliminary prospectus) as such persons reasonably may request in order to facilitate the public sale or
other disposition of the Restricted Stock and Additional Restricted Stock covered by such registration statement; 
 (d) use its
best efforts to register or qualify the Restricted Stock and Additional Restricted Stock covered by such registration statement under the securities or “blue sky” laws of such jurisdictions as the sellers of Restricted Stock and Additional
Restricted Stock or, in the case of an underwritten public offering, the managing underwriter reasonably shall 

  
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request, provided, however, that the Company shall not for any such purpose be required to qualify generally to transact business as a foreign corporation in any jurisdiction where
it is not so qualified or to consent to general service of process in any such jurisdiction; 
 (e) use its best efforts to list
the Restricted Stock and Additional Restricted Stock covered by such registration statement with any securities exchange or automated quotation system on which the Common Stock of the Company is then listed; 

(f) immediately notify each seller of Restricted Stock and Additional Restricted Stock and each underwriter under such registration
statement, at any time when a prospectus relating thereto is required to be delivered under the Securities Act, of the happening of any event of which the Company has knowledge as a result of which the prospectus contained in such registration
statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in light of the circumstances then existing; and

 (g) make available for inspection by each seller of Restricted Stock and Additional Restricted Stock, any underwriter
participating in any distribution pursuant to such registration statement, and any attorney, accountant or other agent retained by such seller or underwriter, all financial and other records, pertinent corporate documents and properties of the
Company, and cause the Company’s officers, directors and employees to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or agent in connection with such registration statement. 

For purposes of Section 7(a) and 7(b) and of Section 4(c), the period of distribution of Restricted Stock and Additional
Restricted Stock in a firm commitment underwritten public offering shall be deemed to extend until each underwriter has completed the distribution of all securities purchased by it, and the period of distribution of Restricted Stock and Additional
Restricted Stock in any other registration shall be deemed to extend until the earlier of the sale of all Restricted Stock and Additional Restricted Stock covered thereby and 180 days after the effective date thereof. 

In connection with each registration hereunder, the sellers of Restricted Stock and Additional Restricted Stock will furnish to the
Company in writing such information with respect to themselves and the proposed distribution by them as reasonably shall be necessary in order to assure compliance with federal and applicable state securities laws. 

In connection with each registration pursuant to Sections 4, 5 or 6 covering an underwritten public offering, the Company and each
selling holder of Restricted Stock and Additional Restricted Stock agree to enter into a written agreement with the managing underwriter selected in the manner herein provided in such form and containing such provisions as are customary in the
securities business for such an arrangement between such underwriter and companies of the Company’s size and investment stature. 
 (h) Notwithstanding the other provisions of this Agreement, the Company’s obligation to file a registration statement, or cause such registration statement to become and remain effective, may be
suspended on one (1) occasion in any 12-month period for a period not 

  
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to exceed 90 days if there exists at the time material non-public information relating to the Company and in the good faith opinion of the Board of Directors of the Company it would be seriously
detrimental to the Company for such registration statement to become effective. In addition, the parties hereto acknowledge the Company may notify holders and suspend use of an effective registration statement for a similar period. 

8. Expenses. All expenses incurred by the Company in complying with Sections 4, 5 and 6, including, without limitation, all
registration and filing fees, printing expenses, fees and disbursements of counsel and independent public accountants for the Company, fees and expenses (including counsel fees) incurred in connection with complying with state securities or
“blue sky” laws, fees of the Financial Industry Regulatory Authority, transfer taxes, fees of transfer agents and registrars, costs of insurance and fees and disbursements of one special counsel for the sellers of Restricted Stock and
Additional Restricted Stock (such special counsel’s fees not to exceed $40,000 in the aggregate for each such registration), but excluding any Selling Expenses, are called “Registration Expenses.” All underwriting discounts and
selling commissions applicable to the sale of Restricted Stock and Additional Restricted Stock are called “Selling Expenses.” 
 The Company will pay all Registration Expenses in connection with each registration statement under Sections 4, 5 or 6. All Selling Expenses in connection with each registration statement under Sections
4, 5 or 6 shall be borne by the participating sellers in proportion to the number of shares sold by each, or by such participating sellers other than the Company (except to the extent the Company shall be a seller) as they may agree. 

9. Indemnification and Contribution. 
 (a) In the event of a registration of any of the Restricted Stock or Additional Restricted Stock under the Securities Act pursuant to Sections 4, 5 or 6, the Company will indemnify and hold harmless each
seller of such Restricted Stock and Additional Restricted Stock thereunder, each underwriter of such Restricted Stock and Additional Restricted Stock thereunder and each other person, if any, who controls such seller or underwriter within the
meaning of the Securities Act, against any losses, claims, damages or liabilities, joint or several, to which such seller, underwriter or controlling person may become subject under the Securities Act or otherwise, insofar as such losses, claims,
damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in any registration statement under which such Restricted Stock or Additional
Restricted Stock was registered under the Securities Act pursuant to Sections 4, 5 or 6, any preliminary prospectus or final prospectus contained therein, or any amendment or supplement thereof, or arise out of or are based upon the omission or
alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, and will reimburse each such seller, each such underwriter and each such controlling person for any legal or
other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action as the same are incurred, provided, however, that the Company will not be liable in any such
case if and to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission so made in conformity with information furnished by any such
seller, any such underwriter or any such controlling 

  
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person in writing specifically for use in such registration statement or prospectus or from a failure of such seller to comply with the prospectus delivery requirements of the Securities Act if
the Company has delivered to such seller any reasonable number of correct or corrected prospectuses requested by such seller. 

(b) In the event of a registration of any of the Restricted Stock or Additional Restricted Stock under the Securities Act pursuant to
Sections 4, 5 or 6, each seller of such Restricted Stock or Additional Restricted Stock thereunder, severally and not jointly, will indemnify and hold harmless the Company, each person, if any, who controls the Company within the meaning of the
Securities Act, each officer of the Company who signs the registration statement, each director of the Company, each underwriter and each person who controls any underwriter within the meaning of the Securities Act, against all losses, claims,
damages or liabilities, joint or several, to which the Company or such officer, director, underwriter or controlling person may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions
in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in the registration statement under which such Restricted Stock or Additional Restricted Stock was registered under
the Securities Act pursuant to Sections 4, 5 or 6, any preliminary prospectus or final prospectus contained therein or any amendment or supplement thereof or arise out of or are based upon the omission or alleged omission to state therein a material
fact required to be stated therein or necessary to make the statements therein not misleading and will reimburse the Company and each such officer, director, underwriter and controlling person for any legal or other expenses reasonably incurred by
them in connection with investigating or defending any such loss, claim, damage, liability or action, provided, however, that such seller will be liable hereunder in any such case if and only to the extent that any such loss, claim,
damage or liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with information pertaining to such seller, as such, furnished in writing to
the Company by such seller specifically for use in such registration statement or prospectus, and provided, further, however, that the liability of each seller hereunder shall be limited to the proportion of any such loss, claim,
damage, liability or expense which is equal to the proportion that the public offering price of the shares sold by such seller under such registration statement bears to the total public offering price of all securities sold thereunder, but not in
any event to exceed the proceeds received by such seller from the sale of Restricted Stock or Additional Restricted Stock covered by such registration statement. 
 (c) Promptly after receipt by an indemnified party hereunder of notice of the commencement of any action, such indemnified party shall, if a claim in respect thereof is to be made against the indemnifying
party hereunder, notify the indemnifying party in writing thereof, but the omission so to notify the indemnifying party shall not relieve it from any liability which it may have to such indemnified party other than under this Section 9 and
shall only relieve it from any liability which it may have to such indemnified party under this Section 9 if and to the extent the indemnifying party is prejudiced by such omission. In case any such action shall be brought against any
indemnified party and it shall notify the indemnifying party of the commencement thereof, the indemnifying party shall be entitled to participate in and, to the extent it shall wish, to assume and undertake the defense thereof with counsel
satisfactory to such indemnified party, and, after notice from the indemnifying party to such indemnified party of its election so to assume and undertake the defense thereof, the indemnifying party shall not

  
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be liable to such indemnified party under this Section 9 for any legal expenses subsequently incurred by such indemnified party in connection with the defense thereof other than reasonable
costs of investigation and of liaison with counsel so selected, provided, however, that, if the defendants in any such action include both the indemnified party and the indemnifying party and the indemnified party shall have reasonably
concluded that there may be reasonable defenses available to it which are different from or additional to those available to the indemnifying party or if the interests of the indemnified party reasonably may be deemed to conflict with the interests
of the indemnifying party, the indemnified party shall have the right to select a separate counsel and to assume such legal defenses and otherwise to participate in the defense of such action, with the expenses and fees of such separate counsel and
other expenses related to such participation to be reimbursed by the indemnifying party as incurred. 
 (d) If for any reason
the indemnification provided for in this Section 9 is held by a court of competent jurisdiction to be unavailable to an indemnified person in respect of any losses, claims, damages, expenses or liabilities referred to therein, then each
indemnifying party under this Section 9, in lieu of indemnifying such indemnified party thereunder, shall contribute to the amount paid or payable by such indemnified party as a result of such losses, claims, damages, expenses or liabilities in
such proportion as is appropriate to reflect the relative fault of the Company, the selling holders of Restricted Stock and Additional Restricted Stock and the underwriters in connection with the statements or omissions which resulted in such
losses, claims, damages, expenses or liabilities, as well as any other relevant equitable considerations. The relative fault of the Company, the selling holders of Restricted Stock and Additional Restricted Stock and the underwriters shall be
determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company, the selling holders of
Restricted Stock and Additional Restricted Stock or the underwriters, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. Notwithstanding the foregoing,
(A) no holder will be required to contribute any amount in excess of the public offering price of all such Restricted Stock or Additional Restricted Stock offered by it pursuant to such registration statement; and (B) no person or entity
guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any person or entity who was not guilty of such fraudulent misrepresentation. 

10. Changes in Common Stock or Preferred Stock. If, and as often as, there is any change in the Common Stock or the Preferred
Stock by way of a stock split, stock dividend, combination or reclassification, or through a merger, consolidation, reorganization or recapitalization, or by any other means, appropriate adjustment shall be made in the provisions hereof so that the
rights and privileges granted hereby shall continue with respect to the Common Stock or the Preferred Stock as so changed. 

11. Rule 144 Reporting. With a view to making available the benefits of certain rules and regulations of the Commission which may
at any time permit the sale of the Restricted Stock or Additional Restricted Stock to the public without registration, at all times after 90 days after any registration statement covering a public offering of securities of the Company under the
Securities Act shall have become effective, the Company agrees to: 
 (a) make and keep public information available, as those
terms are understood and defined in Rule 144 under the Securities Act; 

  
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 (b) use its best efforts to file with the Commission in a timely manner all reports and
other documents required of the Company under the Securities Act and the Exchange Act; and 
 (c) furnish to each holder of
Restricted Stock or Additional Restricted Stock forthwith upon request a written statement by the Company as to its compliance with the reporting requirements of such Rule 144 and of the Securities Act and the Exchange Act, a copy of the most recent
annual or quarterly report of the Company, and such other reports and documents so filed by the Company as such holder may reasonably request in availing itself of any rule or regulation of the Commission allowing such holder to sell any Restricted
Stock or Additional Restricted Stock without registration. 
 12. Representations and Warranties of the Company. The
Company represents and warrants to the Investors as follows: 
 (a) The execution, delivery and performance of this Agreement by
the Company have been duly authorized by all requisite corporate action and will not violate any provision of law, any order of any court or other agency of government, the Certificate of Incorporation or By-laws of the Company or any provision of
any indenture, agreement or other instrument to which it or any or its properties or assets is bound, conflict with, result in a breach of or constitute (with due notice or lapse of time or both) a default under any such indenture, agreement or
other instrument or result in the creation or imposition of any lien, charge or encumbrance of any nature whatsoever upon any of the properties or assets of the Company. 
 (b) This Agreement has been duly executed and delivered by the Company and constitutes the legal, valid and binding obligation of the Company, enforceable in accordance with its terms. 

 

	 	13.	Binding Arbitration. 

(a) Any controversies, disputes, actions, causes of action or other claims between the parties arising out of or relating to this
Agreement, or the breach, termination or validity hereof, or any other matters related thereto (a “Controversy”), whether during the term of this Agreement or otherwise, which are not resolved by mutual agreement within forty-five
(45) days of first written notification by one party to the other parties of the existence of the Controversy (which notification must set forth in reasonable detail the specific points in dispute) shall be finally settled by arbitration before
a neutral arbitrator in accordance with the Commercial Arbitration Rules of the American Arbitration Association (“AAA”) then in effect (modified only as herein expressly provided). The arbitrator shall be experienced with regard to
commercial disputes of the type for which arbitration is being sought. The arbitration shall be before one arbitrator mutually agreed upon by the parties. In the event the parties cannot reach agreement upon an arbitrator, an arbitrator shall be
appointed by the Director of the Washington, D.C., office of AAA. Each party must continue to perform their respective obligations under this Agreement despite the existence of the Controversy. The parties agree that the arbitration will be

  
 - 11 -

 
held in Washington, D.C., or in such other place as the parties may mutually agree upon. The arbitration will be held in accordance with and subject to the procedural rules and applicable
requirements and procedures of the District of Columbia. The arbitrator may enter a default decision against any party who fails to participate in the arbitration proceedings. The decision of the arbitrator on the points in dispute with respect to
such Controversy will be final, non-appealable and binding and judgment on the award may be entered in any court having jurisdiction thereof. The parties agree that this clause has been included to rapidly and inexpensively resolve any Controversy,
and that this clause shall be grounds for dismissal of any court action commenced by any party arising out of or relating to this Agreement or the breach, termination or validity hereof or any other matters relating thereto; provided that nothing in
this Section 13 shall limit any party’s right to bring (i) post-arbitration actions seeking to enforce an arbitration award or (ii) actions seeking injunctive or other similar relief in the event of the breach or threatened
breach of any of the provisions of this Agreement. The parties shall keep confidential, and shall not disclose to any person (except (A) to the extent required by law, and (B) for disclosure to those employees and agents of any such party
who have a need to know and who have been advised of their obligations of confidentiality and non-disclosure hereunder), the existence of any Controversy hereunder, the referral of any such Controversy to arbitration or the status or resolution
thereof. 
 (b) The parties hereto agree that the party or parties which are principally prevailing in any such Controversy
shall be entitled to full reimbursement of all out-of-pocket costs incurred by such prevailing party and its affiliates in connection with such Controversy (including reimbursement of all reasonable attorneys’ fees and expenses) and the
arbitrator is hereby empowered to include such reimbursement in any award or determination. In the event that there is no party which is principally prevailing in any such Controversy, the arbitrator will be authorized to apportion its fees and
expenses and the reasonable attorneys’ fees and expenses of the parties as the arbitrator deems appropriate, and in the absence of any such apportionment, the fees and expenses of the arbitrator will be borne equally by all parties involved in
such arbitration, and each party will bear the fees and expenses of its own attorney. 
 (c) With respect to any action or
proceeding which a successful party to the arbitration may wish to bring to enforce any arbitral award or to seek injunctive or other similar relief in the event of the breach or threatened breach of this Agreement, each party irrevocably and
unconditionally (and without limitation): 
 (i) submits to and accepts, for itself and in respect of its assets, generally and
unconditionally the non-exclusive jurisdiction of the courts of the United States and of the State of Delaware; 
 (ii) waives
any objection it may have now or in the future that such action or proceeding has been brought in an inconvenient forum; 

(iii) agrees that in any such action or proceeding it will not raise, rely on or claim any immunity (including, without limitation, from
suit, judgment, attachment before judgment or otherwise, execution or other enforcement); 

  
 - 12 -

 (iv) waives any right of immunity which it has or its assets may have at any time; and

 (v) consents generally to the giving of any relief or the issue of any process in connection with any such action or
proceeding including, without limitation, the making, enforcement or execution of any order or judgment against any of its property. 
 14. Miscellaneous. 
 (a) All covenants and agreements contained in this
Agreement by or on behalf of any of the parties hereto shall bind and inure to the benefit of the respective successors and assigns of the parties hereto (including without limitation transferees of any Preferred Shares, Restricted Stock or
Additional Restricted Stock), whether so expressed or not, provided, however, that registration rights conferred herein on the holders of Preferred Shares, Restricted Stock or Additional Restricted Stock shall only inure to the benefit
of a transferee of Preferred Shares, Restricted Stock or Additional Restricted Stock if the Company is provided with notice of the transfer and either (i) the transferee acquires 5,500,000 shares (subject to equitable adjustment in the event of
any stock dividend, stock split, combination, reorganization, recapitalization, reclassification or other similar event affecting such shares) or (ii) such transferee is (A) in the case of a party hereto who is a natural person, an
immediate family member or trust for the benefit of such holder or (B) a partner, retired partner, member, retired member, shareholder or affiliate of a party hereto; and provided, further that, upon written notice and with the
written consent of the Company (such consent not to be unreasonably withheld or unduly delayed), the Company shall grant the registration rights conferred herein to any transferee of Preferred Shares, Restricted Stock or Additional Restricted Stock
of at least 3,000,000 shares (subject to equitable adjustment in the event of any stock dividend, stock split, combination, reorganization, recapitalization, reclassification or other similar event affecting such shares). 

(b) All notices, requests, consents and other communications hereunder shall be in writing and shall be delivered in person, mailed by
certified or registered mail, return receipt requested, or sent by telecopier or telex, addressed as follows: 
 (i) if to the
Company, at the address of its principal office; 
 (ii) if to any other party to this Agreement, at its address on the records
maintained by the Company; 
 (iii) if to any subsequent holder of Preferred Shares, Restricted Stock or Additional Restricted
Stock, to it at such address as may have been furnished to the Company in writing by such holder; 
 or, in any case, at such other address or
addresses as shall have been furnished in writing to the Company (in the case of a holder of Preferred Shares, Restricted Stock or Additional Restricted Stock) or to the holders of Preferred Shares, Restricted Stock or Additional Restricted Stock
(in the case of the Company) in accordance with the provisions of this paragraph. 

  
 - 13 -

 (c) This Agreement shall be governed by and construed in accordance with the laws of the
State of Delaware without giving effect to any choice or conflict of law provision or rule that would cause the application of the laws of any other state. 

(d) This Agreement may not be amended or modified, and no provision hereof may be waived, without the written
consent of the Company and the Investors holding at least sixty-six and two-thirds percent (66  2/3%) of the combined outstanding shares of Restricted Stock and Additional Restricted Stock, voting together as a single
class. Notwithstanding the foregoing, no provision of this Agreement shall be amended, modified or terminated, nor shall the observance of any term of this Agreement be waived, unless such amendment, modification, termination or waiver, as the case
may be, applies in the same material respects to all Investors, unless such affected Investor consents to such amendment, modification, termination or waiver. 
 (e) This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

(f) The obligations of the Company to register shares of Restricted Stock and Additional Restricted Stock under
Sections 4, 5 or 6 shall terminate on the twentieth
(20th) anniversary of the date of this Agreement.

 (g) In connection with the initial underwritten public offering of securities of the Company, each holder (including the
Founders and the University) of Restricted Stock or Additional Restricted Stock who is a party to this Agreement agrees not to sell, assign, transfer, pledge, hypothecate, mortgage, encumber or otherwise dispose any shares of Restricted Stock,
Additional Restricted Stock or any other shares of Common Stock then held by such holder (other than shares of Restricted Stock, Additional Restricted Stock or other shares of Common Stock being registered in such offering), without the consent of
the underwriters managing such offering, for a period of not more than 180 days following the effective date of the registration statement relating to such offering, if all persons holding in excess of 1% of the capital stock of the Company on a
fully diluted basis and all executive officers and directors of the Company shall be similarly restricted. 
 (h) The Company
shall not grant to any third party any registration rights more favorable than or inconsistent with any of those contained herein, so long as any of the registration rights under this Agreement remains in effect. 

(i) If any provision of this Agreement shall be held to be illegal, invalid or unenforceable, such illegality, invalidity or
unenforceability shall attach only to such provision and shall not in any manner affect or render illegal, invalid or unenforceable any other provision of this Agreement, and this Agreement shall be carried out as if any such illegal, invalid or
unenforceable provision were not contained herein. 
 (j) This Agreement, together with the other writings referred to herein or
delivered pursuant hereto which form a part hereof, contains the entire agreement among the parties with respect to the subject matter hereof and amends, restates and supersedes all prior and contemporaneous arrangements or understandings, whether
written or oral, with respect thereto, 

  
 - 14 -

 
including without limitation (a) that certain Third Amended and Restated Registration Rights Agreement, dated as of July 15, 2008, among the Company, the Founders and the Investors
named therein; (b) that certain Second Amended and Restated Registration Rights Agreement, dated as of May 16, 2006, among the Company, the Founders and the Investors named therein, (c) that certain Amended and Restated Registration
Rights Agreement, dated as of October 13, 2004, among the Company, the Founders and the Investors named therein, (d) that certain Registration Rights Agreement dated October 27, 2003 between the Company and Genzyme Corporation,
(e) that certain Registration Rights Agreement dated as of September 15, 2000, by and among the Company and the Investors and Founders named therein, as amended by (i) that certain Amendment No.1 to Registration Rights Agreement dated
as of December 4, 2000, by and among the Company, Alexandria Real Estate Equities, L.P. (“ARE”), and the Founders and Investors named therein, (ii) that certain Amendment No. 2 to Registration Rights Agreement dated
as of June 10, 2002, by and among the Company, the Board of Regents of the University of Texas System (the “University”), and the New Purchasers, Founders and Investors named therein, (iii) that certain Amendment
No. 3 to Registration Rights Agreement, dated as of October 27, 2003, by and among the Company, the University and the New Purchasers, Founders, and Investors named therein, and (f) Section 16 of that certain Warrant for the
Purchase of Shares of Common Stock granted to ARE, dated October 31, 2000. 
 (k) Notwithstanding anything to the contrary
in this Agreement, the Company and Eli Lilly & Company (“Lilly”) each acknowledge and agree that Lilly shall not have any rights or liabilities under this Agreement unless and until Lilly acquires any Securities pursuant to
that certain Securities Purchase Agreement, dated as of September 19, 2008, by and among the Company and the Purchasers (including Lilly) named therein (the “Purchase Agreement”). The terms “Securities” and
“Purchasers”, as used in this Section 14(k), shall have the meanings ascribed to such terms in the Purchase Agreement. 
 [Remainder of Page Intentionally Left Blank] 

  
 - 15 -

 IN WITNESS WHEREOF, this Agreement has been executed by the New Investors as of the date
first written above and approved and adopted by the written consent of the Existing Investors and the Series D Investors in accordance with Section 14(d) of the Third Amended and Restated Registration Rights Agreement. 

 

			
	MACROGENICS, INC.
		
	By:	 	 /s/ Scott Koenig

	Name:	 	Scott Koenig, M.D., PhD
	Title:	 	President & Chief Executive Officer

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	NEW INVESTORS:
	
	ONC PARTNERS, L.P.
		
	By:	 	 /s/ MARTIN PAUL

	Name:	 	MARTIN PAUL
	Title:	 	DIRECTOR
	FOR AND ON BEHALF OF ONC GENERAL PARTNER LIMITED, AS GENERAL PARTNER OF ONC PARTNERS, L.P.
	
	INNOVIS INVESTMENTS, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	ARCUS VENTURES, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	NEW INVESTORS:
	
	ONC PARTNERS, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	INNOVIS INVESTMENTS, L.P.
		
	By:	 	 /s/ Hans Peter Bissinger

	Name:	 	Hans Peter Bissinger
	Title:	 	General Partner
	
	ARCUS VENTURES, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	NEW INVESTORS:
	
	ONC PARTNERS, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	INNOVIS INVESTMENTS, L.P.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	ARCUS VENTURES, L.P.
		
	By:	 	 /s/ James B Dougherty

	Name:	 	James B Dougherty
	Title:	 	General Partner

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	ELI LILLY AND COMPANY
		
	By:	 	 illegible

	Name:	 	
	Title:	 	

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	ALEXANDRIA EQUITIES, LLC,
	a Delaware limited liability company
	
	By: ALEXANDRIA REAL ESTATE EQUITIES, INC.,
	a Maryland corporation, managing member
		
	By:	 	 /s/ Dean A. Shigenaga

	Name:	 	Dean A. Shigenaga
	Title:	 	Chief Financial Officer

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

			
	FOUNDERS:
	
	 The Scott Koenig Family Trust

		
	 By:
	 	  

	 Name:
	 	
	 Trustee:
	 	
	
	 /s/ Scott Koenig

	 Scott Koenig

	
	 /s/ Jeffrey Ravetch

	 Jeffrey Ravetch

	
	 /s/ Leroy Hood

	 Leroy Hood

	
	 /s/ Alan Aderem

	 Alan Aderem

	
	 /s/ Ruedi Aebersold

	 Ruedi Aebersold

	
	 The Institute for Systems Biology

		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	

  
 Signature
Pages to Fourth Amended and Restated Registration Rights Agreement 

 EXHIBIT A 
 Existing Investors 
 Ventures West 8 Limited Partnership 

Rivervest Venture Fund I, L.P. 
 Caisse De Depot
Et Placement du Quebec 
 Alta Biopharma Partners III, L.P. 
 Alta Biopharma Partners III GMBH & Co. Beteiligungs KG 
 Alta Embarcadero Biopharma
Partners III, LLC 
 TPG Ventures, L.P. 

TPG Biotechnology Partners, L.P. 
 Red Abbey
Venture Partners (QP), LP 
 Red Abbey Venture Partners, LP 
 Red Abbey CEO’s Fund, LP 
 MPM Bioventures II, L.P. 

MPM Bioventures II-QP, L.P. 
 MPM Bioventures
GMBH & Co. Parallel-Beteiligungs KG 
 MPM Asset Management Investors 2000 B LLC 

MPM Bioventures IV Strategic Fund LP 
 Interwest
Partners VIII, L.P. 
 Interwest Investors VIII, L.P. 
 Interwest Investors Q-VIII, L.P. 
 Mirtha Ventures, L.P. 

Cogene Biotech Ventures, L.P. 
 Orbimed
Associates LLC 
 Caduceus Private Investments, LP 
 UBS Juniper Crossover Fund, L.L.C. 
 The Board of Regents of the University of Texas System

 Startech Seed Fund II, L.P. 

 EXHIBIT B 
 Series D Investors 
 Bear Stearns Health Innoventures Employee Fund, L.P.

 Bear Stearns Health Innoventures Offshore, L.P. 
 Bear Stearns Health Innoventures, L.P. 
 BSHI Members, L.L.C. 

BX, L.P. 
 BioMedical Sciences Investment Fund
Pte Ltd 
 Biogen Idec MA, Inc. 
 Grand
Cathay Venture Capital Co., LTD. 
 Grand Cathay Venture Capital III Co., LTD. 
 Prudence Venture Investment Corp. 
 CMEA Life Sciences Fund, L.P. 

CMEA Ventures Life Sciences 2000, Civil Law Partnership 
 CMEA Ventures Life Sciences 2000, L.P. 
 Cogene Biotech Ventures, L.P. 

Jennifer Fonstad 
 H&Q Healthcare Investors

 H&Q Life Sciences Investors 

Integra Ventures III, L.P. 
 Montgomery RAVEN
Partnership 
 MUFG Venture Capital I, Limited Partnership 
 Pequot Healthcare Venture Fund, L.P. 
 Pequot Offshore Private Equity Partners III, L.P.

 Pequot OHV Fund, L.P. 
 Pequot
Private Equity Fund III, L.P. 
 PHCV RAVEN Series D Grantor Trust 
 Ridgeback Capital Investments L.P. 
 Saints Capital V, L.P. 

2180 Associates Fund VII, L.P. 
 U.S. Venture
Partners VII, L.P. 
 USVP Entrepreneur Partners VII-A, L.P. 
 USVP Entrepreneur Partners VII-B, L.P. 
 Vulcan Capital Venture Capital I LLC 

HCP Life Science Assets TRS, LLC 

Montgomery & Co., LLC 
 George G.
Montgomery 
 Keith W. Marshall 
 Jeremy
TaylorEX-10.1

 Exhibit 10.1 
 MACROGENICS, INC. 
 2000 STOCK OPTION
AND INCENTIVE PLAN 
  

	1.	Purpose and Eligibility 

 The purpose of this 2000 Stock Option and Incentive Plan (the “Plan”) of MacroGenics. Inc. (the “Company”) is to provide stock options and other equity interests in the
Company (each, an “Award”) to employees, officers, directors, consultants and advisors of the Company and its Subsidiaries, all of whom are eligible to receive Awards under the Plan. Any person to whom an Award has been granted
under the Plan is called a “Participant.” Additional definitions are contained in Section 8. 
  

	2.	Administration 

 a.
Administration by Board of Directors. The Plan will be administered by the Board of Directors of the Company (the “Board”). The Board, in its sole discretion, shall have the authority to grant and amend Awards, to adopt,
amend and repeal rules relating to the Plan and to interpret and correct the provisions of the Plan and any Award. All decisions by the Board shall be final and binding on all interested persons. Neither the Company nor any member of the Board shall
be liable for any action or determination relating to the Plan. 
 b. Appointment of Committees. To the extent permitted
by applicable law, the Board may delegate any or all of its powers under the Plan to one or more committees or subcommittees of the Board (a “Committee”). All references in the Plan to the “Board” shall mean such
Committee or the Board. 
 c. Delegation to Executive Officers. To the extent permitted by applicable law, the Board may
delegate to one or more executive officers of the Company who are also directors of the Company the power to grant Awards and exercise such other powers under the Plan as the Board may determine, provided that the Board shall fix the maximum
number of Awards to be granted and the maximum number of shares issuable to any one Participant pursuant to Awards granted by such executive officers. 
  

	3.	Stock Available for Awards 

 a. Number of Shares. Subject to adjustment under Section 3(c), the aggregate number of shares of common stock, $.01 par value per share, of the Company (the “Common Stock”)
that may be issued pursuant to the Plan is 4,000,000 shares. If any Award, or shares of Common Stock issued pursuant to an Award, expires or is terminated, repurchased, surrendered, forfeited or settled in cash (other than repurchases or cash
settlements purported to be made at fair market value), in whole or in part, the Common Stock issued or issuable pursuant to such Award as to which such event has occurred shall again be available for the grant of Awards under the Plan. Shares
issued under the Plan may consist in whole or in part of authorized but unissued shares or treasury shares. 

 b. Per-Participant Limit. Subject to adjustment under Section 3(c), no
Participant may be granted Awards during any one fiscal year to purchase more than 1,000,000 shares of Common Stock. 
 c.
Adjustment to Common Stock. In the event of any stock split, stock dividend, extraordinary cash dividend, recapitalization, reorganization, merger, consolidation, combination, exchange of shares, liquidation, spin-off, split-up, or other
similar change in capitalization or event, (i) the number and class of securities available for Awards under the Plan and the per-Participant share limit, (ii) the number and class of securities, vesting schedule and exercise price per
share subject to each outstanding Option, (iii) the repurchase price per security subject to repurchase, and (iv) the terms of each other outstanding stock-based Award shall be adjusted by the Company (or substituted Awards may be made) to
the extent the Board shall determine, in good faith, that such an adjustment (or substitution) is appropriate. If Section 7(e)(i) applies for any event, this Section 3(c) shall not be applicable. 

 

	4.	Stock Options 

 a.
General. The Board may grant options to purchase Common Stock (each, an “Option”) and determine the number of shares of Common Stock to be covered by each Option, the exercise price of each Option and the conditions and
limitations applicable to the exercise of each Option and the Common Stock issued upon the exercise of each Option, including vesting provisions, repurchase provisions and restrictions relating to applicable federal or state securities laws, as it
considers advisable. 
 b. Incentive Stock Options. An Option that the Board intends to be an “incentive stock
option” as defined in Section 422 of the Code (an “Incentive Stock Option”) shall be granted only to employees of the Company and shall be subject to and shall be construed consistently with the requirements of
Section 422 of the Code. The Board and the Company shall have no liability if an Option or any part thereof that is intended to be an Incentive Stock Option does not qualify as such. An Option or any part thereof that does not qualify as an
Incentive Stock Option is referred to herein as a “Nonstatutory Stock Option.” 
 c. Exercise Price. The
Board shall establish the exercise price (or determine the method by which the exercise price shall be determined) at the time each Option is granted and specify it in the applicable option agreement. 

d. Duration of Options. Each Option shall be exercisable at such times and subject to such terms and conditions as the Board may
specify in the applicable option agreement. 
 e. Exercise of Option. Options may be exercised only by delivery to the
Company of a written notice of exercise signed by the proper person together with payment in full as specified in Section 4(f) for the number of shares for which the Option is exercised. 

  
 - 2 -

 f. Payment Upon Exercise. Common Stock purchased upon the exercise of an Option shall
be paid for by one or any combination of the following forms of payment: 
 (i) by check payable to the order of the Company;

 (ii) except as otherwise explicitly provided in the applicable option agreement, and only if the Common Stock is then
publicly traded, delivery of an irrevocable and unconditional undertaking by a creditworthy broker to deliver promptly to the Company sufficient funds to pay the exercise price, or delivery by the Participant to the Company of a copy of irrevocable
and unconditional instructions to a creditworthy broker to deliver promptly to the Company cash or a check sufficient to pay the exercise price; or 
 (iii) to the extent explicitly provided in the applicable option agreement, by (x) delivery of shares of Common Stock owned by the Participant valued at fair market value (as determined by the Board
or as determined pursuant to the applicable option agreement), (y) delivery of a promissory note of the Participant to the Company (and delivery to the Company by the Participant of a check in an amount equal to the par value of the shares
purchased), or (z) payment of such other lawful consideration as the Board may determine. 
  

	5.	Restricted Stock 

a. Grants. The Board may grant Awards entitling recipients to acquire shares of Common Stock, subject to (i) delivery to the
Company by the Participant of a check in an amount at least equal to the par value of the shares purchased, and (ii) the right of the Company to repurchase all or part of such shares at their issue price or other stated or formula price from
the Participant in the event that conditions specified by the Board in the applicable Award are not satisfied prior to the end of the applicable restriction period or periods established by the Board for such Award (each, a “Restricted Stock
Award”). 
 b. Terms and Conditions. The Board shall determine the terms and conditions of any such Restricted
Stock Award. Any stock certificates issued in respect of a Restricted Stock Award shall be registered in the name of the Participant and, unless otherwise determined by the Board, deposited by the Participant, together with a stock power endorsed in
blank, with the Company (or its designee). After the expiration of the applicable restriction periods and upon the request of the Participant, the Company (or such designee) shall deliver the certificates no longer subject to such restrictions to
the Participant or, if the Participant has died, to the beneficiary designated by a Participant, in a manner determined by the Board, to receive amounts due or exercise rights of the Participant in the event of the Participant’s death (the
“Designated Beneficiary”). In the absence of an effective designation by a Participant, Designated Beneficiary shall mean the Participant’s estate. 

  
 - 3 -

	6.	Other Stock-Based Awards 

 The Board shall have the right to grant other Awards based upon the Common Stock having such terms and conditions as the Board may determine, including, without limitation, the grant of shares based upon
certain conditions, the grant of securities convertible into Common Stock and the grant of stock appreciation rights, phantom stock awards or stock units. 
  

	7.	General Provisions Applicable to Awards 

 a. Transferability of Awards. Except as the Board may otherwise determine or provide in an Award, Awards shall not be sold, assigned, transferred, pledged or otherwise encumbered by the person to
whom they are granted, either voluntarily or by operation of law, except by will or the laws of descent and distribution, and, during the life of the Participant, shall be exercisable only by the Participant. References to a Participant, to the
extent relevant in the context, shall include references to authorized transferees. 
 b. Documentation. Each Award under
the Plan shall be evidenced by a written instrument in such form as the Board shall determine or as executed by an officer of the Company pursuant to authority delegated by the Board. Each Award may contain terms and conditions in addition to those
set forth in the Plan provided that such terms and conditions do not contravene the provisions of the Plan. 
 c.
Board Discretion. The terms of each type of Award need not be identical, and the Board need not treat Participants uniformly. 
 d. Termination of Status. The Board shall determine the effect on an Award of the disability, death, retirement, authorized leave of absence or other change in the employment or other status of a
Participant and the extent to which, and the period during which, the Participant, or the Participant’s legal representative, conservator, guardian or Designated Beneficiary, may exercise rights under the Award. 

e. Acquisition of the Company 
 (i) Consequences of an Acquisition. 
 (A) Acquisition Intended to be
Accounted for as a Pooling-of-interests. Upon the consummation of an Acquisition intended to be accounted for as a pooling-of-interests: all outstanding Awards shall remain the obligation of the Company or be assumed by the surviving or
acquiring entity, and there shall be automatically substituted for the shares of Common Stock then subject to such Awards the consideration payable with respect to the outstanding shares of Common Stock in connection with the Acquisition.

 (B) Acquisition Intended to be Accounted for under the Purchase Method. Unless otherwise expressly provided in the
applicable Option or Award, upon the occurrence of an Acquisition intended to be accounted for under the purchase method, the Board 

  
 - 4 -

 
or the board of directors of the surviving or acquiring entity (as used in this Section 7(e)(i)(B), also the “Board”), shall, as to outstanding Awards (on the same basis or
on different bases, as the Board shall specify), make appropriate provision, subject to Section 7(e)(i)(C), for the continuation of such Awards by the Company or the assumption of such Awards by the surviving or acquiring entity and by
substituting on an equitable basis for the shares then subject to such Awards either (a) the consideration payable with respect to the outstanding shares of Common Stock in connection with the Acquisition, (b) shares of stock of the
surviving or acquiring corporation or (c) such other securities as the Board deems appropriate, the fair market value of which (as determined by the Board in its sole discretion) shall not materially differ from the fair market value of the
shares of Common Stock subject to such Awards immediately preceding the Acquisition. In addition to or in lieu of the foregoing, with respect to outstanding Options, the Board may, upon written notice to the affected optionees, provide that one or
more Options must be exercised, to the extent then exercisable or to be exercisable as a result of the Acquisition in accordance with Section 7(e)(i)(C) and as permitted by Section 7(i), within a specified number of days of the date of
such notice, at the end of which period such Options shall terminate; or terminate one or more Options in exchange for a cash payment equal to the excess of the fair market value (as determined by the Board in its sole discretion) of the shares
subject to such Options (to the extent then exercisable or to be exercisable as a result of the Acquisition or as permitted by Section 7(i)) over the exercise price thereof. 

(C) Acquisitions Generally. Upon the consummation of an Acquisition, the exercisability of Options, the vesting provisions of
Restricted Stock Awards, and the exercisability of and/or vesting provisions under other stock-based Awards shall be accelerated, if at all, in accordance with the terms and conditions of the written instrument evidencing any such Options.
Restricted Stock Awards or other stock-based Awards approved by the Board. 
 (D) Acquisition Defined. An
“Acquisition” shall mean: (x) the consolidation with or acquisition by another entity in a merger, reorganization, consolidation of other form of business combination in which the other entity is the surviving or successor
entity and the holders of outstanding voting stock of the Company immediately preceding the consummation of such event, shall, immediately following such event, hold, as a group, less than a majority of the voting securities of the surviving or
successor entity; or (y) any sale of all or substantially all of the assets or capital stock of the Company (other than in a spin-off or similar transaction) or (z) any other acquisition of the business of the Company, as determined by the
Board. 
 (ii) Assumption of Options Upon Certain Events. In connection with a merger or consolidation of an entity with
the Company or the acquisition by the Company of property or stock of an entity, the Board may grant Awards under the Plan in substitution for stock and stock-based awards issued by such entity or an affiliate thereof. The substitute Awards shall be
granted on such terms and conditions as the Board considers appropriate in the circumstances. 
 (iii) Pooling-of-Interests
Accounting. If the Company proposes to engage in an Acquisition intended to be accounted for as a pooling-of-interests, and in the event that the 

  
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provisions of this Plan or of any Award hereunder, or any actions of the Board taken in connection with such Acquisition, are determined by the Company’s or the acquiring company’s
independent public accountants to cause such Acquisition to fail to be accounted for as a pooling-of-interests, then such provisions or actions shall be amended or rescinded by the Board, without the consent of any Participant, to be consistent with
pooling-of-interests accounting treatment for such Acquisition. 
 (iv) Parachute Awards. Notwithstanding the provisions
of any Option, Restricted Stock Award or other stock-based Award, if, in connection with the consummation of an Acquisition as described in Section 7(e)(i)(D), a tax under Section 4999 of the Code would be imposed on the Participant (after
taking into account the exceptions set forth in Sections 280G(b)(4) and 280G(b)(5) of the Code), then the number of Awards which shall become exercisable, realizable or vested as provided in such written instrument evidencing such Option, Restricted
Stock Award or other stock-based Award shall be reduced (or delayed), to the minimum extent necessary, so that no such tax would be imposed on the Participant (the Awards not becoming so accelerated, realizable or vested, the “Parachute
Awards”); provided, however, that if the “aggregate present value” of the Parachute Awards would exceed the tax that, but for this sentence, would be imposed on the Participant under Section 4999 of the
Code in connection with the Acquisition, then the Awards shall become immediately exercisable, realizable and vested without regard to the provisions of this sentence. For purposes of the preceding sentence, the “aggregate present
value” of an Award shall be calculated on an after-tax basis (other than taxes imposed by Section 4999 of the Code) and shall be based on economic principles rather than the principles set forth under Section 280G of the Code and
the regulations promulgated thereunder. All determinations required to be made under this Section 7(e)(iv) shall be made by the Company. 
 f. Withholding. Each Participant shall pay to the Company, or make provisions satisfactory to the Company for payment of, any taxes required by law to be withheld in connection with Awards to such
Participant no later than the date of the event creating the tax liability. The Board may allow Participants to satisfy such tax obligations in whole or in part by transferring shares of Common Stock, including shares retained from the Award
creating the tax obligation, valued at their fair market value (as determined by the Board or as determined pursuant to the applicable option agreement). The Company may, to the extent permitted by law, deduct any such tax obligations from any
payment of any kind otherwise due to a Participant. 
 g. Amendment of Awards. The Board may amend, modify or terminate
any outstanding Award including, but not limited to, substituting therefor another Award of the same or a different type, changing the date of exercise or realization, and converting an Incentive Stock Option to a Nonstatutory Stock Option,
provided that, except as otherwise provided in Section 7(e)(iii), the Participant’s consent to such action shall be required unless the Board determines that the action, taking into account any related action, would not materially
and adversely affect the Participant. 
 h. Conditions on Delivery of Stock. The Company will not be obligated to deliver
any shares of Common Stock pursuant to the Plan or to remove restrictions from shares 

  
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previously delivered under the Plan until (i) all conditions of the Award have been met or removed to the satisfaction of the Company, (ii) in the opinion of the Company’s counsel,
all other legal matters in connection with the issuance and delivery of such shares have been satisfied, including any applicable securities laws and any applicable stock exchange or stock market rules and regulations, and (iii) the Participant
has executed and delivered to the Company such representations or agreements as the Company may consider appropriate to satisfy the requirements of any applicable laws, rules or regulations. 

i. Acceleration. The Board may at any time provide that any Options shall become immediately exercisable in full or in part, that
any Restricted Stock Awards shall be free of some or all restrictions, or that any other stock-based Awards may become exercisable in full or in part or free of some or all restrictions or conditions, or otherwise realizable in full or in part, as
the case may be, despite the fact that the foregoing actions may (i) cause the application of Sections 280G and 4999 of the Code if a change in control of the Company occurs, or (ii) disqualify all or part of the Option as an Incentive
Stock Option. 
  

	8.	Miscellaneous 

 a.
Definitions. 
 (i) “Company,” for purposes of eligibility under the Plan, shall include any present or
future subsidiary corporations of MacroGenics, Inc., as defined in Section 424(f) of the Code (a “Subsidiary”), and any present or future parent corporation of MacroGenics, Inc., as defined in Section 424(e) of the Code.
For purposes of Awards other than Incentive Stock Options, the term “Company” shall include any other business venture in which the Company has a direct or indirect significant interest, as determined by the Board in its sole
discretion. 
 (ii) “Code” means the Internal Revenue Code of 1986, as amended, and any regulations promulgated
thereunder. 
 b. No Right To Employment or Other Status. No person shall have any claim or right to be granted an Award,
and the grant of an Award shall not be construed as giving a Participant the right to continued employment or any other relationship with the Company. The Company expressly reserves the right at any time to dismiss or otherwise terminate its
relationship with a Participant free from any liability or claim under the Plan. 
 c. No Rights As Stockholder. Subject
to the provisions of the applicable Award, no Participant or Designated Beneficiary shall have any rights as a stockholder with respect to any shares of Common Stock to be distributed with respect to an Award until becoming the record holder
thereof. 
 d. Effective Date and Term of Plan. The Plan shall become effective on the date on which it is adopted by the
Board. No Awards shall be granted under the Plan after the completion of ten years from the date on which the Plan was adopted by the Board, but Awards previously granted may extend beyond that date. 

  
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 e. Amendment of Plan. The Board may amend, suspend or terminate the Plan or any
portion thereof at any time. 
 f. Governing Law. The provisions of the Plan and all Awards made hereunder shall be
governed by and interpreted in accordance with the laws of Delaware, without regard to any applicable conflicts of law. 
  

	
	Adopted by the Board of Directors on:
	December 13, 2000
	
	Approved by the stockholders on:
	December 13, 2000

  
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 REGISTER OF AMENDMENTS 

 

							
	 Amendment No.
	  	 Date
	  	 Section
	  	 Description

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