Document:

EX-4.7

 Exhibit 4.7 
  

BERKSHIRE HATHAWAY INC. 

OFFICERS’ CERTIFICATE 

ESTABLISHING THE TERMS OF 2.368% SENIOR NOTES DUE 2052 

December 8, 2022 
 The
undersigned, Marc D. Hamburg and Robert P. Reeson, do hereby certify pursuant to Section 3.01 of that certain Indenture, dated as of January 28, 2022 (the “Indenture”), among Berkshire Hathaway Inc. (the
“Company”), Berkshire Hathaway Finance Corporation and The Bank of New York Mellon Trust Company, N.A., as trustee, that: 

1. They are (i) the Senior Vice President and Chief Financial Officer and (ii) the Assistant Secretary, respectively, of the Company.

 2. As such officers, they are authorized to execute and deliver this Officers’ Certificate on behalf of the Company. 

3. Attached hereto as Annex A is a true and correct copy of a specimen note representing the Company’s 2.368% Senior Notes
due 2052 (the “Notes”). 
 4. The Notes are a separate series of Securities under the Indenture. The terms of the Notes set
forth in the form of Notes attached hereto as Annex A are incorporated herein by reference. 
 5. The title of the Notes shall be the
“2.368% Senior Notes due 2052.” The Notes will be the Company’s unsecured senior obligations, will rank pari passu in right of payment with all of the Company’s unsubordinated, unsecured indebtedness and will be senior in
right of payment to all of the Company’s subordinated indebtedness. 
 6. The Company will initially issue ¥8,400,000,000 aggregate
principal amount of Notes. The Company may issue additional Notes from time to time after the date hereof, and such Notes will be treated as part of the same series of Notes for all purposes under the Indenture. 

7. The principal amount of the Notes will mature on December 6, 2052. 

8. The Notes are issuable in minimum denominations of ¥100,000,000 and integral multiples of ¥10,000,000 in excess thereof. 

9. Interest on the Notes for any full semi-annual interest period will be computed on the basis of a
360-day year of twelve 30-day months. The amount of interest payable for any period shorter than a full semi-annual interest period for which interest is computed will
be computed on the basis of 30-day months and, for periods of less than a month, the actual number of days elapsed per 30-day month. 

  
 - 1 - 

 10. The Notes will bear interest from December 8, 2022 at the rate of 2.368% per annum,
payable on each June 8 and December 8, commencing on June 8, 2023, to the holders of record of the Notes at the close of business on the preceding May 24 and November 23 (whether or not a Business Day), as the case may be,
immediately preceding such June 8 or December 8, or if the Notes are represented by one or more global securities, the close of business on the business day (for this purpose a day on which Euroclear Bank S.A/N.V.
(“Euroclear”) and Clearstream Banking, société anonyme (“Clearstream”) are open for business) immediately preceding the interest payment date. 

11. Payment of the principal of and premium, if any, and interest on the Notes will be made at the office or agency of the Company maintained
for that purpose in The City of London, England, which shall be initially the corporate trust office of The Bank of New York Mellon, London Branch, located at 160 Queen Victoria Street, London EC4V 4LA; provided, however, that at the
option of the Company payments of principal, premium or interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register, subject to surrender at such office or agency, in the
case of payments of principal or premium. 
 12. All payments of interest and principal on the Notes, including payments made upon any
redemption of the Notes, will be made in yen. If the yen is unavailable to the Company due to the imposition of exchange controls or other circumstances beyond the Company’s control, then all payments in respect of the Notes will be made in
United States dollars until the yen is again available to the Company or so used. The amount payable on any date in yen will be converted into U.S. dollars at the rate mandated by the U.S. Federal Reserve Board as of the close of business on the
second Business Day prior to the relevant payment date or, in the event the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the most recent U.S. dollar/yen exchange rate published in The Wall Street Journal on or
prior to the second Business Day prior to the relevant payment date or, in the event the Wall Street Journal has not published such exchange rate, the rate will be determined in the Company’s sole discretion on the basis of the most recently
available market exchange rate for yen (in each case, the “Market Exchange Rate”). The Market Exchange Rate most recently available on, or prior to, the second Business Day before the relevant determination date will be the basis
for determining the equivalent of yen in the currency of the United States of America for any purpose under the Indenture, including for purposes of the definition of “Outstanding” in Section 1.01(f) of the Indenture. Any payment in
respect of the Notes so made in U.S. dollars will not constitute an Event of Default under the Notes or the Indenture. Neither the Trustee nor the Paying Agent shall have any responsibility for any calculation or conversion in connection with the
foregoing. 
 13. The Notes will initially be issued in the form of one or more Global Securities and registered in the name of the nominee
of the common depositary for the accounts of Clearstream and Euroclear. The Bank of New York Mellon, London Branch shall initially serve as the Depositary for such Global Securities. 

14. The Paying Agent for the Notes will be The Bank of New York Mellon, London Branch. Notwithstanding the foregoing, upon notice to the
Trustee, the Company may change the Paying Agent. 
 15. The Notes shall be defeasible in whole or in part pursuant to the terms of the
Indenture, including, without limitation, Section 13.02 and Section 13.03 of the Indenture. 

  
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 16. The Company will be obligated to pay additional amounts on the Notes as described under
the heading “Payment of Additional Amounts” in the form of the Notes incorporated herein by reference (such amounts, the “Additional Amounts”). 

At least 10 days prior to the first Interest Payment Date and at least 10 days prior to each date of payment of principal or interest on the
Notes if there has been a change with respect to the matters set forth in the below-mentioned Officers’ Certificate last delivered to the Trustee and the principal Paying Agent, if other than the Trustee, the Company shall furnish to the
Trustee and the principal Paying Agent, if other than the Trustee, an Officers’ Certificate instructing the Trustee and such Paying Agent whether such payment of principal or interest on the Notes shall be made to Holders without withholding or
deduction for or on account of any taxes described under the heading “Payment of Additional Amounts” in the form of the Notes incorporated herein by reference. If any such withholding or deduction shall be required, then such
Officers’ Certificate shall specify by country the amount, if any, required to be withheld or deducted on such payments to such Holders and shall certify the fact that Additional Amounts will be payable and the amounts so payable to each
Holder, and the Company shall pay to the Trustee or such Paying Agent such Additional Amounts required to be paid under the Notes. 

Whenever in the Notes there is mentioned, in any context, the payment of the principal of or any premium, interest or any other amounts on, or
in respect of, the Notes, such mention shall be deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof pursuant to the terms hereof, and
express mention of the payment of Additional Amounts in any provision of the Notes shall not be construed as excluding the payment of Additional Amounts in those provisions thereof where such express mention is not made. 

17. The Notes may be redeemed in whole or in part pursuant to the terms set forth in the form of the Notes incorporated herein by reference.
The Company shall give the Trustee notice of the redemption price promptly after the calculation thereof and the Trustee shall have no responsibility for such calculation. Prior to the giving of any notice of redemption with respect to a redemption
arising from the payment of Additional Amounts, the Company shall deliver to the Trustee an Officers’ Certificate to the effect that all conditions precedent provided for in the Indenture to such redemption have been complied with. 

18. The Notes and the authentication pages to the Notes may be executed in any number of counterparts, each of which shall be deemed an
original, but all of which shall constitute one and the same instrument. The Trustee may authenticate the Notes by manual, facsimile or electronic signature. Electronically imaged signatures such as .pdf files, faxed signatures or other electronic
signatures to the Notes and the authentication pages to the Notes shall have the same effect as original signatures. 
 All capitalized
terms used herein and not otherwise defined shall have the meanings given such terms in the Indenture. 
 [Remainder of page intentionally
left blank.] 

  
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 IN WITNESS WHEREOF, this Officers’ Certificate has been executed by the undersigned as
of the date first written above. 
  

			
	 /s/ Marc D. Hamburg

	Name:	 	Marc D. Hamburg
	Title:	 	Senior Vice President and Chief Financial Officer
	
	 /s/ Robert P. Reeson

	Name:	 	Robert P. Reeson
	Title:	 	Assistant Secretary

 [BRK Officers’ Certificate Establishing Terms of 2.368% Senior Notes due 2052 (JPY)] 

 ANNEX A 

SPECIMEN OF NOTE 

 2.368% Senior Notes due 2052 

CERTIFICATE OF AUTHENTICATION 
 This is one of the
Securities of the series designated therein referred to in the within-mentioned Indenture. 
  

			
	 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.

as Trustee,

		
	        By:	 	              

		 	Name:
		 	Title:

 Dated: December 8, 2022 

 THIS DEBT SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS
REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS DEBT SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS DEBT SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY
PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 UNLESS THIS CERTIFICATE IS
PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR BANK, S.A./N.V., AS OPERATOR OF THE EUROCLEAR SYSTEM (“EUROCLEAR”), AND CLEARSTREAM BANKING, SOCIÉTÉ ANONYME, LUXEMBOURG (“CLEARSTREAM” AND, TOGETHER WITH
EUROCLEAR, “EUROCLEAR/CLEARSTREAM”), TO BERKSHIRE HATHAWAY INC. OR ITS AGENT FOR REGISTRATION OR TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR
IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR/CLEARSTREAM (AND ANY PAYMENT IS MADE TO THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
EUROCLEAR/CLEARSTREAM), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED, HAS AN INTEREST HEREIN. 

 BERKSHIRE HATHAWAY INC. 

************************** 

2.368% Senior Notes due 2052 

CUSIP: 084670DQ8 

ISIN: XS2561173712 

COMMON CODE: 256117371 
  

			
	No.	  	¥
		  	 (as revised by the Schedule of Increases and

Decreases in Global Security attached hereto)

 BERKSHIRE HATHAWAY INC., a corporation duly organized and existing under the laws of the State of Delaware
(herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to The Bank of New York Depository (Nominees) Limited, the registered Holder
hereof, as nominee of The Bank of New York Mellon, London Branch as common depositary for Euroclear Bank, S.A./N.V. (“Euroclear”) and Clearstream Banking, société anonyme (“Clearstream”), the principal sum of
Yen (¥ ) (as revised by the Schedule of Increases and Decreases in Global Security attached hereto) on December 6, 2052, and to pay interest thereon from and including December 8, 2022 or from and
including the most recent Interest Payment Date (as defined below) to which interest has been paid or duly provided for, semi-annually on June 8 and December 8 in each year, commencing June 8, 2023 (each an “Interest Payment
Date”), at the rate of 2.368% per annum (as adjusted, if at all, pursuant to such Indenture, the “Interest Rate”), until the principal hereof is paid or made available for payment; provided that any principal, and any such
installment of interest, which is overdue shall bear interest at the Interest Rate (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are due until they are paid or made available for payment,
and such interest shall be payable on demand. Interest on the Debt Securities of this series for any full semi-annual interest period will be computed on the basis of a 360-day year of twelve 30-day months. The amount of interest payable for any period shorter than a full semi-annual interest period for which interest is computed will be computed on the basis of
30-day months and, for periods of less than a month, the actual number of days elapsed per 30-day month. 

The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid
to the Person in whose name this Debt Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date (whether or not a Business Day) for such interest. Any such interest not so punctually paid or
duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Debt Security (or one or more Predecessor Securities) is registered at the close of business on a
Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Debt Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any
time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Debt Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in such
Indenture. 

 “Business Day” means any day, other than a Saturday or Sunday, that is not a day
on which banking institutions in the Borough of Manhattan, The City of New York or London or Tokyo are authorized or required by law, regulation or executive order to close and that is a day on which the Trans-European Automated Real-time Gross
Settlement Express Transfer System (the TARGET2 system), or any successor thereto, operates. 
 “Regular Record Date” means, with
respect to any Interest Payment Date, the May 24 and November 23 (whether or not a Business Day) or, if this Debt Security is represented by one or more Global Securities, the close of business on the business day (for this purpose a day
on which Clearstream and Euroclear are open for business), in each case, immediately preceding such Interest Payment Date. 
 Payment of the
principal of and premium, if any, and interest on this Debt Security will be made at the office or agency of the Company maintained for that purpose in the City of London, England, which shall be initially the corporate trust office of The Bank of
New York Mellon, London Branch, located at 160 Queen Victoria Street, London EC4V 4LA; provided, however, that at the option of the Company payments of principal, premium or interest may be made by check mailed to the address of the Person
entitled thereto as such address shall appear in the Security Register, subject to surrender at such office or agency, in the case of payments of principal or premium. 

All payments on this Debt Security will be made in yen; provided, that if on or after December 1, 2022, the yen is unavailable to
the Company due to the imposition of exchange controls or other circumstances beyond the Company’s control, then all payments in respect of this Debt Security will be made in U.S. dollars until the yen is again available to the Company or so
used. The amount payable on any date in yen will be converted into U.S. dollars at the rate mandated by the U.S. Federal Reserve Board as of the close of business on the second Business Day prior to the relevant payment date or, in the event the
U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. dollar/yen exchange rate published in The Wall Street Journal on or prior to the second Business Day prior to the relevant payment date or,
in the event the Wall Street Journal has not published such exchange rate, the rate will be determined in the Company’s sole discretion on the basis of the most recently available market exchange rate for yen. Any payment in respect of this
Debt Security so made in U.S. dollars will not constitute an Event of Default with respect to the Debt Securities of this series or under the Indenture governing the Debt Securities. Neither the Trustee nor the Paying Agent shall have any
responsibility for any calculation or conversion in connection with the foregoing. 
 “yen” and “¥” means the lawful
currency of Japan. 
 Reference is hereby made to the further provisions of this Debt Security set forth on the reverse hereof, which
further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication
hereon has been executed by the Trustee referred to on the reverse hereof by manual, facsimile or electronic signature, this Debt Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose.

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

							
	Dated: December 8, 2022	 		 		 	BERKSHIRE HATHAWAY INC.
				
		 		 	By:	 	
                     

		 		 	Name:	 	Marc D. Hamburg
		 		 	Title:	 	Senior Vice President and Chief Financial Officer

  

			
	Attest:
	
	
                 

	Name:	 	Robert P. Reeson
	Title:	 	Assistant Secretary

 [REVERSE OF DEBT SECURITY] 

This Debt Security is one of a duly authorized series of notes of the Company (herein called the “Debt Securities”), issued and to
be issued in one or more series under an Indenture, dated as of January 28, 2022 (herein called the “Base Indenture”, and as supplemented by the Officers’ Certificate dated December 8, 2022 with respect to this Debt
Security, together with the Base Indenture, called the “Indenture”), among the Company, as issuer, Berkshire Hathaway Finance Corporation, and The Bank of New York Mellon Trust Company, N.A., as Trustee (herein called the
“Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Debt Securities and of the terms upon which the Debt Securities are, and are to be, authenticated and delivered. This Debt Security is one of the series designated on the face hereof, initially limited in aggregate
principal amount to ¥8,400,000,000. The Company may at any time issue additional securities under the Indenture in unlimited amounts having the same terms as the Debt Securities of a series, provided that no additional securities of a series may
be issued if at the time of issuance an Event of Default has occurred and is continuing with respect to such series of securities. 
 This
Debt Security does not have the benefit of any sinking fund obligation. 
 If, as a result of any change in, or amendment to, the laws (or
any regulations or rulings promulgated under the laws) of the United States (or any political subdivision of or taxing authority in the United States), or any change in, or amendment to, an official position regarding the application or
interpretation of such laws, regulations or rulings (including a holding by a court of competent jurisdiction in the United States), which change or amendment is announced or becomes effective on or after December 1, 2022, the Company becomes
or, based upon a written opinion of independent counsel selected by the Company, there is a substantial probability that the Company will become, obligated to pay additional amounts as described under the heading “Payment of Additional
Amounts,” below, with respect to the Debt Securities of this series, then the Company may at any time at its option redeem the Debt Securities of this series, in whole but not in part, at a redemption price equal to 100% of their principal
amount, together with accrued and unpaid interest on the Debt Securities being redeemed to, but excluding, the date fixed for redemption. 

The Company must give the Holders of this Debt Security notice, as provided in the Indenture, of any redemption of this Debt Security not less
than 30 days or more than 60 days before the date fixed for redemption. If the Company elects to redeem fewer than all the Debt Securities of this series, the Trustee will select the particular Debt Securities of this series to be redeemed by such
method that the Trustee deems fair and appropriate; provided, that if the Debt Securities of this series are represented by one or more Global Securities, beneficial interests therein shall be selected for redemption by Clearstream and
Euroclear in accordance with their respective applicable procedures therefor; provided further, that no Debt Securities of this series of a principal amount of ¥100,000,000 or less shall be redeemed in part. 

In the event of redemption of this Debt Security in part only, a new Debt Security or Debt Securities of this series and of like tenor for the
unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 The Indenture contains provisions
for defeasance at any time of the entire Indebtedness of this Debt Security or of certain restrictive covenants and Events of Default with respect to this Debt Security, in each case upon compliance with certain conditions set forth in the
Indenture. 

 If an Event of Default with respect to the Debt Securities of this series shall occur and be
continuing, the principal of the Debt Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 

The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations
of the Company and the rights of the Holders of the Debt Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a majority in principal amount of the
Debt Securities at the time Outstanding of each series to be affected (voting together as a single class). The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Debt Securities of each
series at the time Outstanding, on behalf of the Holders of all Debt Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any
such consent or waiver by the Holder of this Debt Security shall be conclusive and binding upon such Holder and upon all future Holders of this Debt Security and of any Debt Security issued upon the registration of transfer hereof or in exchange
herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Debt Security. 
 As provided in and subject
to the provisions of the Indenture, the Holder of this Debt Security shall not have the right to institute any proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such
Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to the Debt Securities of this series, the Holders of at least 33% in principal amount of the Debt Securities of this series at the time
Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the Trustee indemnity or security reasonably satisfactory to it, and the Trustee shall not have received
from the Holders of a majority in principal amount of Debt Securities of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such
notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Debt Security for the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due
dates expressed herein. 
 No reference herein to the Indenture and no provision of this Debt Security or of the Indenture shall alter or
impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any interest on this Debt Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Debt Security is registrable in the
Security Register, upon surrender of this Debt Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Debt Security are payable, duly endorsed by, or
accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or the Holder’s attorney duly authorized in writing, and thereupon one or more new Debt
Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Indenture and this Debt Security are governed by the laws of the State of New York, without regard to conflicts of laws provisions
thereof. 

 The Debt Securities of this series are issuable in registered form without coupons in
minimum denominations of ¥100,000,000 and integral multiples of ¥10,000,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Debt Securities of this series are exchangeable for a like
aggregate principal amount of Debt Securities of this series and of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. 

No service charge shall be made to a Holder for any such registration of transfer or exchange, but the Company may require payment of a sum
sufficient to cover any tax or other governmental charge payable in connection therewith. 
 Prior to due presentment of this Debt Security
for registration of transfer, the Company, the Trustee and any agent thereof may treat the Person in whose name this Debt Security is registered as the owner hereof for all purposes, whether or not this Debt Security be overdue, and none of the
Company, the Trustee or any such agent shall be affected by notice to the contrary. 
 Except in the limited circumstances described in
Section 3.05 of the Indenture, the Debt Securities of this series shall be issued in the form of one or more Global Securities and a common depositary for the accounts of Euroclear and Clearstream shall be the Depositary for such Global
Security or Securities. 
 All terms used in this Debt Security which are not defined herein and are defined in the Indenture shall have the
meanings assigned to them in the Indenture. 
 Payment of Additional Amounts 

All payments of principal and interest in respect of the Debt Securities of this series shall be made free and clear of, and without deduction
or withholding for or on account of any present or future taxes, duties, assessments or other governmental charges of whatsoever nature required to be deducted or withheld by the United States or any political subdivision or taxing authority of or
in the United States, unless such withholding or deduction is required by law or the official interpretation or administration thereof. 

In the event any withholding or deduction on payments in respect of the Debt Securities of this series for or on account of any present or
future tax, assessment or other governmental charge is required to be deducted or withheld by the United States or any political subdivision or taxing authority thereof or therein, the Company shall pay such additional amounts on the Debt Securities
of this series as will result in receipt by each beneficial owner of such Debt Security that is not a U.S. Person (as defined below) of such amounts (after all such withholding or deduction, including on any additional amounts) as would have been
received by such beneficial owner had no such withholding or deduction been required. The Company will not be required, however, to make any payment of additional amounts for or on account of: 

 

	(a)	 any tax, assessment or other governmental charge that would not have been imposed but for (1) the
existence of any present or former connection (other than a connection arising solely from the ownership of those Debt Securities or the receipt of payments in respect of those Debt Securities) between a Holder of a Debt Security of this series (or
the beneficial owner for whose benefit such Holder holds such Debt Security), or between a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a power over, that Holder or beneficial owner (if that Holder or beneficial
owner is an estate, trust, partnership or corporation) and the United States, including that Holder or beneficial owner, or that fiduciary, settlor, beneficiary, member, shareholder or possessor, being or having been a citizen or resident or treated
as a resident of the United States or being or having been engaged in trade or business or present in the United States or having had a permanent establishment in the United States or (2) the presentation of a Debt Security of this series for
payment on a date more than 30 days after the later of the date on which that payment becomes due and payable and the date on which payment is duly provided for; 

	(b)	 any estate, inheritance, gift, sales, transfer, capital gains, excise, personal property, wealth or similar
tax, assessment or other governmental charge; 

  

	(c)	 any tax, assessment or other governmental charge imposed by reason of the beneficial owner’s past or
present status as a passive foreign investment company, a controlled foreign corporation, a foreign tax exempt organization or a personal holding company with respect to the United States or as a corporation that accumulates earnings to avoid U.S.
federal income tax; 

  

	(d)	 any tax, assessment or other governmental charge which is payable by any method other than withholding or
deducting from payment of principal of or premium, if any, or interest on the Debt Securities of this series; 

  

	(e)	 any tax, assessment or other governmental charge required to be withheld by any Paying Agent from any payment
of principal of and premium, if any, or interest on any Debt Security of this series if that payment can be made without withholding by any other Paying Agent; 

 

	(f)	 any tax, assessment or other governmental charge which would not have been imposed but for the failure of a
beneficial owner or any Holder of Debt Securities of this series to comply with the Company’s request or a request of the Company’s agent to satisfy certification, information, documentation or other reporting requirements concerning the
nationality, residence, identity or connections with the United States of the beneficial owner or any Holder of the Debt Securities of this series that such beneficial owner or Holder is legally able to deliver (including, but not limited to, the
requirement to provide an applicable Internal Revenue Service Form W-8, or any subsequent versions thereof or successor thereto, and including, without limitation, any documentation requirement under an
applicable income tax treaty); 

  

	(g)	 any tax, assessment or other governmental charge imposed on interest received by (1) a 10-percent shareholder (as defined in Section 871(h)(3)(B) of the U.S. Internal Revenue Code of 1986, as amended (the “Code”), and the U.S. Treasury regulations that may be promulgated thereunder) of
the Company, (2) a controlled foreign corporation that is related to the Company within the meaning of Section 864(d)(4) of the Code or (3) a bank receiving interest described in Section 881(c)(3)(A) of the Code, to the extent
such tax, assessment or other governmental charge would not have been imposed but for the beneficial owner’s status as described in clauses (1) through (3) of this item (g); 

 

	(h)	 any tax, assessment or other governmental charge required to be withheld or deducted under Sections 1471
through 1474 of the Code (or any amended or successor version of such Sections) (“FATCA”), any regulations or other guidance thereunder, or any agreement (including any intergovernmental agreement) entered into in connection therewith; or
any law, regulation or other official guidance enacted in any jurisdiction implementing FATCA or an intergovernmental agreement in respect of FATCA; or 

  

	(i)	 any combination of items (a), (b), (c), (d), (e), (f), (g) and (h); 

nor will the Company pay any additional amounts to any beneficial owner or Holder of Debt Securities of this series who is a fiduciary or partnership
(including any entity treated as a partnership for U.S. federal income tax purposes) to the extent that a beneficiary or settlor with respect to that fiduciary or a member of that partnership or a beneficial owner thereof would not have been
entitled to the payment of those additional amounts had that beneficiary, settlor, member or beneficial owner been the beneficial owner of those Debt Securities. 

 “U.S. Person” means any individual who is a citizen or resident of the United
States for U.S. federal income tax purposes, a corporation, partnership or other entity created or organized in or under the laws of the United States, any state of the United States or the District of Columbia (other than a partnership that is not
treated as a United States person under any applicable U.S. Treasury regulations), or any estate or trust the income of which is subject to United States federal income taxation regardless of its source. 

 SCHEDULE OF INCREASES OR DECREASES IN GLOBAL SECURITY 

The following increases or decreases in this Debt Security have been made: 

 

									
	 Date of exchange
	 	 Amount of decrease in

principal amount of
 this Debt
Security
	 	 Amount of increase in

principal amount of this
 Debt
Security
	 	 Principal amount of this

Debt Security following
 such decrease
or increase
	 	 Signature of authorized

signatory of Trustee or
 Security
Custodian

 ASSIGNMENT 

FOR VALUE RECEIVED, the undersigned assigns and transfers this Debt Security to: 

————————————————————————————————————————
 

————————————————————————————————————————
 
 (Insert assignee’s social security or tax identification number) 

————————————————————————————————————————
 

————————————————————————————————————————
 

———————————————————————————————————————-
 
 (Insert address and zip code of assignee) 

and irrevocably appoints _______ as agent to transfer this Debt Security on the Security Register. The agent may substitute another to act for him or her.

 Dated:
            Signature:                  

                        
Signature Guarantee: 
 (Sign exactly as your name appears on the other side of this Debt Security) 

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar, which requirements include
membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution for, STAMP, all
in accordance with the Securities Exchange Act of 1934, as amended.Exhibit
10.1

 

Execution Version

 

STOCK PURCHASE AGREEMENT

 

By and Between

 

ENTRADA THERAPEUTICS, INC.

 

AND

 

VERTEX PHARMACEUTICALS INCORPORATED

 

Dated as of December 7, 2022

 

     

     

    

 

 

TABLE OF CONTENTS

 

	 	 	 	Page
	 	 	 	 
	1.	Definitions	1
	 	 	 	 
	 	1.1 	Defined Terms	1
	 	1.2	Additional Defined Terms	3
	 	 	 	 
	2.	Purchase and Sale of Common Stock	4
	 	 	 	 
	3.	Closing Date; Deliveries	4
	 	 	 	 
	 	3.1 	Closing Date	4
	 	3.2 	Deliveries	4
	 	 	 	 
	4.	Representations and Warranties of the Company	5
	 	 	 	 
	 	4.1 	Organization, Good Standing and Qualification	5
	 	4.2 	Capitalization and Voting Rights	5
	 	4.3 	Subsidiaries	6
	 	4.4	Authorization	6
	 	4.5	No Defaults	6
	 	4.6	No Conflicts	6
	 	4.7 	No Governmental Authority or Third Party Consents	7
	 	4.8 	Valid Issuance of Shares	7
	 	4.9 	Litigation	7
	 	4.10 	Company SEC Documents; Financial Statements; Nasdaq
    Stock Market	7
	 	4.11 	Absence of Certain Changes	8
	 	4.12 	No Undisclosed Material Liabilities	8
	 	4.13 	Offering	9
	 	4.14 	No Integration	9
	 	4.15 	Brokers’ or Finders’ Fees	9
	 	4.16 	Internal Controls; Disclosure Controls and Procedures	9
	 	4.17 	Not an Investment Company	9
	 	4.18 	Regulation M Compliance	9
	 	 	 	 
	5.	Representations and Warranties of the Investor	9
	 	 	 	 
	 	5.1 	Organization	9
	 	5.2 	Authorization	9
	 	5.3 	No Conflicts	10
	 	5.4 	No Governmental Authority or Third Party Consents	10
	 	5.5 	Investor Entirely for Own Account	10
	 	5.6 	Disclosure of Information	10
	 	5.7 	Investment Experience and Accredited Investor Status	11
	 	5.8 	Acquiring Person	11
	 	5.9 	Restricted Securities	11
	 	5.10 	Legends	11
	 	5.11 	Financial Assurances	11
	 	 	 	 
	6.	Investor’s Conditions to Closing	11
	 	 	 	 
	 	6.1 	Transfer Agent Instructions	11
	 	6.2 	Representations and Warranties	11
	 	6.3 	Covenants	12
	 	6.4 	No Material Adverse Effect	12
	 	6.5 	Listing	12
	 	6.6 	License Agreement	12
	 	6.7 	Closing Deliverables	12

 

    i

     

    

 

	7.	Company’s Conditions to Closing	12
	 	 	 	 
	 	7.1 	Representations and Warranties	12
	 	7.2	Covenants	12
	 	7.3 	Closing Deliverables	12
	 	 	 	 
	8.	Mutual Conditions to Closing	12
	 	 	 	 
	 	8.1 	Absence of Litigation	12
	 	8.2	HSR Act	13
	 	8.3 	No Prohibition	13
	 	 	 	 
	9.	Termination	13
	 	 	 	 
	 	9.1 	Ability to Terminate	13
	 	9.2	Automatic Termination	13
	 	9.3	Effect of Termination	14
	 	 	 	 
	10.	Additional Covenants and Agreements	14
	 	 	 	 
	 	10.1 	Standstill	14
	 	10.2 	Lock-Up	15
	 	10.3 	Market Listing	16
	 	10.4 	Assistance and Cooperation	16
	 	10.5 	Rule 144 Reporting	16
	 	10.6 	Voting Agreement	17
	 	 	 	 
	11.	Miscellaneous	19
	 	 	 	 
	 	11.1 	Governing Law; Submission to Jurisdiction	19
	 	11.2 	Waiver	19
	 	11.3 	Notices	19
	 	11.4 	Entire Agreement	19
	 	11.5 	Amendments	19
	 	11.6	Headings; Nouns and Pronouns; Section References	19
	 	11.7 	Severability	19
	 	11.8 	Assignment	20
	 	11.9 	Successors and Assigns	20
	 	11.10 	Counterparts	20
	 	11.11 	Third Party Beneficiaries	20
	 	11.12 	No Strict Construction	20
	 	11.13 	Survival of Warranties	20
	 	11.14 	Remedies	21
	 	11.15 	Expenses	21
	 	11.16 	Public Announcement	21

 

Exhibit A
– Form of Cross Receipt

Exhibit B – Notices

Exhibit C
– Form of Form 8-K

Exhibit D – Form of Irrevocable
Proxy

 

    ii

     

    

 

STOCK PURCHASE AGREEMENT

 

THIS
STOCK PURCHASE AGREEMENT (this “Agreement”), dated as of December 7, 2022, by and between Vertex Pharmaceuticals
Incorporated, a corporation organized under the laws of The Commonwealth of Massachusetts (the “Investor”) with offices
located at 50 Northern Avenue, Boston, Massachusetts 02210, and Entrada Therapeutics, Inc., a corporation organized under the laws
of the State of Delaware (the “Company”), with its principal place of business at 6 Tide Street, Boston, Massachusetts
02210.

 

WHEREAS,
the Company and Investor are party to a Strategic Collaboration and License Agreement (the “License Agreement”)
of even date herewith pursuant to which the Company will perform certain research activities and grant to the Investor an exclusive license
to exploit novel products for the treatment or prevention of myotonic dystrophy type 1.

 

WHEREAS, pursuant
to Section 5.2 of the License Agreement, as partial consideration for the grant by the Company to the Investor of the license contemplated
by the License Agreement, the Company desires to issue, and Investor desires to purchase, shares of common stock, par value $0.0001
per share, of the Company (the “Common Stock”) as herein described, on the terms and conditions hereinafter set forth.

 

WHEREAS, the Company
and the Investor are executing and delivering this Agreement in reliance upon the exemption from securities registration afforded by
the provisions of Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”) and Rule 506
of Regulation D (“Regulation D”), as promulgated by the U.S. Securities and Exchange Commission (the “SEC”)
under the Securities Act.

 

NOW, THEREFORE, in consideration
of the following mutual promises and obligations, and for good and valuable consideration, the adequacy and sufficiency of which are
hereby acknowledged, the Investor and the Company agree as follows:

 

1.             Definitions.

 

1.1            Defined
Terms. When used in this Agreement, the following terms shall have the respective meanings specified therefor below:

 

“Affiliate”
shall mean, with respect to a Person, any other Person which controls, is controlled by or is under common control with the applicable
Person. For purposes of this definition, “control” shall mean: (a) in the case of corporate entities, direct or indirect
ownership of at least fifty percent (50%) of the stock or shares entitled to vote for the election of directors, or otherwise having
the power to control or direct the affairs of such Person; and (b) in the case of non-corporate entities, direct or indirect ownership
of at least fifty percent (50%) of the equity interest or the power to direct the management and policies of such non-corporate entities.

 

“Agreement”
shall have the meaning set forth in the Preamble, including all Exhibits attached hereto.

 

     

     

    

 

“Business Day”
shall mean a day on which the Nasdaq and commercial banking institutions in New York, New York are open for business.

 

“Cross Receipt”
shall mean an executed document signed by each of the Company and the Investor, in substantially the form of Exhibit A attached
hereto.

 

“Effect”
shall have the meaning set forth in the definition of “Material Adverse Effect.”

 

“Governmental
Authority” shall mean any applicable government authority, court, tribunal, arbitrator, agency, department, legislative
body, commission or other instrumentality of (a) any government of any country or territory, (b) any nation, state, province,
county, city or other political subdivision thereof or (c) any supranational body.

 

“Law”
or “Laws” shall mean all laws, statutes, rules, regulations, orders, judgments, injunctions and/or ordinances of any
Governmental Authority.

 

“Material
Adverse Effect” shall mean any change, event or occurrence (each, an “Effect”) that, individually or when
taken together with all other Effects, has (i) a material adverse effect on the business, financial condition, assets, results
of operations or prospects of the Company and its subsidiaries, taken as a whole, or (ii) a material adverse effect on the Company’s
ability to perform its obligations, or consummate the Transaction, in accordance with the terms of this Agreement, except in the case
of (i) or (ii) to the extent that any such Effect results from or arises out of: (A) changes in conditions in the United
States or global economy or capital or financial markets generally, including changes in interest or exchange rates, (B) changes
in general legal, regulatory, political, economic or business conditions or changes in generally accepted accounting principles in the
United States or interpretations thereof that, in each case, generally affect the biotechnology or biopharmaceutical industries, (C) the
announcement of this Agreement or the License Agreement, or the identity of the Investor, (D) any change in the trading prices or
trading volume of the Common Stock (it being understood that the facts giving rise to or contributing to any such change may be deemed
to constitute, or be taken into account when determining whether there has been or will be, a Material Adverse Effect, except to the
extent any of such facts is an Effect referred in clauses (A) through (H) of this definition), (E) acts of war, sabotage
or terrorism, or any escalation or worsening of any such acts of war, sabotage or terrorism, (F) earthquakes, hurricanes, floods
or other natural disasters, (G) any action taken by the Company with the Investor’s written consent, (H) any breach,
violation or non-performance by the Investor or any of its Affiliates under the License Agreement, or (I) shareholder litigation
arising out of or in connection with the execution, delivery or performance of this Agreement or the License Agreement; provided, that
with respect to clauses (A), (B), (E) and (F) such Effect does not have a materially disproportionate and adverse effect on
the Company relative to other companies in the biotechnology or biopharmaceutical industries.

 

“Organizational
Documents” shall mean (i) the Amended and Restated Certificate of Incorporation of the Company dated as of September 17,
2019, as amended through the date of this Agreement and (ii) the Amended and Restated Bylaws of the Company, as amended through
the date of this Agreement.

 

    	 	2	 

     

    

 

“Person”
shall mean any individual, partnership, limited liability company, firm, corporation, trust, unincorporated organization, government
or any department or agency thereof or other entity, as well as any syndicate or group that would be deemed to be a Person under
Section 13(d)(3) of the Exchange Act.

 

“Third Party”
shall mean any Person (other than a Governmental Authority) other than the Investor, the Company or any Affiliate of the Investor or
the Company.

 

“Transaction”
means the issuance and sale of the Shares by the Company, and the purchase of the Shares by the Investor, in accordance with the terms
hereof.

 

“Transaction Agreements”
means this Agreement and the License Agreement.

 

1.2            Additional
Defined Terms. In addition to the terms defined in Section 1.1, the following terms shall have the respective meanings assigned
thereto in the sections indicated below:

 

	Defined
    Term	Section
	Affiliate Irrevocable Proxy

    Aggregate Purchase Price
	Section 10.6(a)

    Section 2

	Agreed Disclosures	Section 11.16
	Agreement 	Preamble
	Board	Section 3.2(a)
	Business Combination	Section 10.1(a)
	Change of Control	Section 10.2
	Closing	Section 3.1
	Closing Date	Section 3.1
	Common Stock	Preamble
	Company	Preamble
	Company SEC Documents	Section 4.10(a)
	Derivative	Section 10.1(a)
	Exchange Act

    Extraordinary Matters

    HSR Act
	Section 4.10(a)

    Section 10.6(d)

    Section 4.7

	Irrevocable Proxy

    LAS
	Section 10.6(b)

    Section 4.7

	License Agreement	Preamble
	Lock-Up Securities	Section 10.2
	Investor	Preamble
	Regulation D	Preamble
	SEC	Preamble
	Securities Act	Preamble
	Share Amount	Section 2
	Shares	Section 2
	Termination Date	Section 9.1
	Transfer	Section 10.2

 

    	 	3	 

     

    

 

2.            Purchase
and Sale of Common Stock. Subject to the terms and conditions of this Agreement, at the Closing, the Company shall issue and sell
to the Investor, free and clear of all liens, other than any liens arising as a result of any action by the Investor, and the Investor
shall purchase from the Company, a number of shares of Common Stock equal to the Share Amount (the “Shares”), for
a purchase price of $16.26 per share and an aggregate purchase price of US $26,318,648 (the “Aggregate Purchase Price”).
The “Share Amount” shall equal 1,618,613 shares of Common Stock; provided, however, that in the event of any stock
dividend, stock split, combination of shares, recapitalization or other similar change in the capital structure of the Company after
the date hereof and on or prior to the Closing which affects or relates to the Common Stock, the Share Amount shall be adjusted proportionately.

 

3.            Closing
Date; Deliveries.

 

3.1            Closing
Date. Subject to the satisfaction or waiver of all the conditions to the Closing set forth in Sections 6, 7 and 8 hereof, the closing
of the purchase and sale of the Shares hereunder (the “Closing”) shall be held on the third (3rd) Business
Day after the satisfaction of the conditions to Closing set forth in Sections 6, 7 and 8 (other than those conditions that by their nature
are to be satisfied at the Closing, but subject to the satisfaction at such time of such conditions), at 10:00 a.m. New York time
(ET), at the offices of Goodwin Procter LLP, 100 Northern Avenue, Boston, Massachusetts 02210, or at such other time, date and location
as the parties may agree. The date the Closing occurs is hereinafter referred to as the “Closing Date.”

 

3.2            Deliveries.

 

(a)            Deliveries
by the Company. At the Closing, the Company shall instruct its transfer agent to register the Shares in book-entry in the name of
the Investor. The Company shall also deliver at the Closing: (i) a duly executed Cross Receipt; (ii) a certificate in form
and substance reasonably satisfactory to the Investor and duly executed on behalf of the Company by an authorized executive officer of
the Company, certifying that the conditions to Closing set forth in Section 6 of this Agreement have been fulfilled; and (iii) a
certificate of the secretary of the Company dated as of the Closing Date certifying (A) that attached thereto is a true and complete
copy of the Amended and Restated Bylaws of the Company as in effect at the time of the actions by the board of directors of the Company
(the “Board”) referred to in clause (B) below, and on the Closing Date; (B) that attached thereto is a true
and complete copy of all resolutions adopted by the Board authorizing the execution, delivery and performance of this Agreement, the
License Agreement and the transactions contemplated respectively therein and that all such resolutions are in full force and effect and
are all the resolutions adopted in connection with the transactions contemplated hereby as of the Closing Date; (C) that attached
thereto is a true and complete copy of the Company’s Amended and Restated Certificate of Incorporation as in effect at the time
of the actions by the Board referred to in clause (B) above, and on the Closing Date.

 

(b)            Deliveries
by the Investor. At the Closing, the Investor shall deliver, or cause to be delivered, to the Company the Aggregate Purchase Price
by wire transfer of immediately available United States funds to an account designated by the Company. The Company shall notify the Investor
in writing of the wiring instructions for such account not less than three (3) Business Days before the Closing Date. The Investor
shall also deliver, or cause to be delivered, at the Closing: (i) a duly executed Cross Receipt; and (ii) a certificate in
form and substance reasonably satisfactory to the Company and duly executed on behalf of the Investor by an authorized executive officer
of the Investor, certifying that the conditions to Closing set forth in Section 7 of this Agreement have been fulfilled.

 

    	 	4	 

     

    

 

4.            Representations
and Warranties of the Company. The Company hereby represents and warrants to the Investor that:

 

4.1            Organization,
Good Standing and Qualification.

 

(a)            The
Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company has
all requisite corporate power and corporate authority to own, lease and operate its properties and assets, to carry on its business as
now conducted, and as proposed to be conducted as described in the Company SEC Documents, to enter into the Transaction Agreements, to
issue and sell the Shares and to carry out the other transactions contemplated by the Transaction Agreements.

 

(b)            The
Company is qualified to transact business and is in good standing in each jurisdiction in which the character of the properties owned,
leased or operated by the Company or the nature of the business conducted by the Company makes such qualification necessary, except where
the failure to be so qualified would not have or be reasonably likely to have a Material Adverse Effect.

 

4.2            Capitalization
and Voting Rights.

 

(a)            The
authorized, issued and outstanding shares of capital stock of the Company are as set forth in the most recent Company SEC Documents (as
defined herein) as of the date indicated therein (except for subsequent issuances, if any, pursuant to this Agreement, pursuant to reservations,
agreements or employee benefit plans referred to in the most recent Company SEC Documents or pursuant to the exercise of convertible
securities or options referred to in the most recent Company SEC Documents). The outstanding shares of capital stock of the Company have
been duly authorized and validly issued, are fully paid and non-assessable and have been issued in compliance with all federal and state
securities laws. None of the outstanding shares of capital stock of the Company were issued in violation of the preemptive or other similar
rights of any securityholder of the Company.

 

(b)            All
of the authorized shares of Common Stock are entitled to one (1) vote per share.

 

(c)            Except
as described or referred to in Section 4.2(a) above and as set forth in the Company SEC Documents, as of the date hereof, there
are not: (i) any outstanding equity securities, options, warrants, rights (including conversion or preemptive rights) or other agreements
pursuant to which the Company is or may become obligated to issue, sell or repurchase any shares of its capital stock or any other securities
of the Company or (ii) any restrictions on the transfer of capital stock of the Company other than pursuant to state and federal
securities Laws.

 

(d)            Except
as set forth in the Company SEC Documents, the Company is not a party to or subject to any agreement or understanding relating to the
voting of shares of capital stock of the Company or the giving of written consents by a stockholder or director of the Company.

 

    	 	5	 

     

    

 

4.3            Subsidiaries.
The Company has disclosed all of its subsidiaries required to be disclosed pursuant to Item 601(b)(21) of Regulation S-K in an exhibit
to its Annual Report on Form 10-K for the fiscal year ended December 31, 2021.

 

4.4            Authorization.

 

(a)            All
requisite corporate action on the part of the Company, its directors and stockholders required by applicable Law for the authorization,
execution and delivery by the Company of the Transaction Agreements, and the performance of all obligations of the Company hereunder
and thereunder, including the authorization, issuance and delivery of the Shares, has been taken.

 

(b)            This
Agreement and the License Agreement have been duly executed and delivered by the Company, and upon the due execution and delivery of
this Agreement and the License Agreement by the Investor, this Agreement and the License Agreement will constitute valid and legally
binding obligations of the Company, enforceable against the Company in accordance with their respective terms (except as such enforceability
may be limited by (i) applicable bankruptcy, insolvency, reorganization, moratorium or other Laws of general application relating
to or affecting enforcement of creditors’ rights and (ii) rules of Law governing specific performance, injunctive relief
or other equitable remedies and limitations of public policy).

 

4.5            No
Defaults. The Company is not in default under or in violation of (a) its Organizational Documents, (b) any provision of
applicable Law or any ruling, writ, injunction, order, Permit, judgment or decree of any Governmental Authority or (c) any agreement,
arrangement or instrument, whether written or oral, by which the Company or any of its assets are bound, except, in the case of subsections
(b) and (c), as would not have or be reasonably likely to have a Material Adverse Effect. To the knowledge of the Company, there
exists no condition, event or act which after notice, lapse of time, or both, would constitute a default or violation by the Company
under any of the foregoing, except, in the case of subsections (b) and (c), as would not have or be reasonably likely to have a
Material Adverse Effect.

 

4.6            No
Conflicts. The execution, delivery and performance of the Transaction Agreements, and compliance with the provisions hereof and thereof
(including the issuance of the Shares), by the Company do not and shall not: (a) violate any provision of applicable Law or any
ruling, writ, injunction, order, permit, judgment or decree of any Governmental Authority, (b) constitute a breach of, or default
under (or an event which, with notice or lapse of time or both, would become a default under) or conflict with, or give rise to any right
of termination, cancellation or acceleration of, any agreement, arrangement or instrument, whether written or oral, by which the Company
or any of its assets are bound, (c) result in any encumbrance upon any of the Shares, other than restrictions on resale pursuant
to securities laws, or on any of the properties or assets of the Company or any subsidiary or (d) violate or conflict with any of
the provisions of the Company’s Organizational Documents, except, in the case of subsections (a), (b) and (c) as would
not have or be reasonably likely to have a Material Adverse Effect with respect to this Agreement.

 

    	 	6	 

     

    

 

4.7            No
Governmental Authority or Third Party Consents. No consent, approval, authorization or other order of, or filing with, or notice
to, any Governmental Authority or other Third Party is required to be obtained or made by the Company in connection with the authorization,
execution and delivery by the Company of any of the Transaction Agreements, or with the authorization, issue and sale by the Company
of the Shares, except (i) such filings as may be required to be made with the SEC and with any state blue sky or securities regulatory
authority, which filings shall be made in a timely manner in accordance with all applicable Laws, (ii) as required pursuant to the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “HSR Act”) and (iii) with respect to the
Shares, the filing with The Nasdaq Stock Market LLC of, and the absence of unresolved issues with respect to, a Notification Form: Listing
of Additional Shares (the “LAS”).

 

4.8            Valid
Issuance of Shares. When issued, sold and delivered at the Closing in accordance with the terms hereof for the Aggregate Purchase
Price, the Shares will be duly authorized, validly issued, fully paid and nonassessable, free from any liens, encumbrances or restrictions
on transfer, including preemptive rights, rights of first refusal or other similar rights as a result of any action by the Investor or
under federal or state securities Laws.

 

4.9            Litigation.
Except as set forth in the Company SEC Documents filed prior to the date of this Agreement, there is no action, suit, proceeding or investigation
pending (of which the Company has received notice or otherwise has knowledge) or, to the Company’s knowledge, threatened, against
the Company or which the Company intends to initiate, where such action, suit, proceeding or investigation, as the case may be, would
reasonably be expected to have a Material Adverse Effect.

 

4.10            Company
SEC Documents; Financial Statements; Nasdaq Stock Market.

 

(a)            The
Common Stock is registered pursuant to Section 12(b) or 12(g) of the Securities Exchange Act of 1934, as amended (the
 “Exchange Act”). Since December 31, 2021, the Company has timely filed all required reports, schedules, forms,
statements and other documents (including exhibits and all other information incorporated therein), and any required amendments to any
of the foregoing, with the SEC (the “Company SEC Documents”). As of their respective filing dates, each of the Company
SEC Documents complied in all material respects with the requirements of the Securities Act, and the Exchange Act, and the rules and
regulations of the SEC promulgated thereunder applicable to such Company SEC Documents, and no Company SEC Documents when filed, declared
effective or mailed, as applicable, contained any untrue statement of a material fact or omitted to state a material fact required to
be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not
misleading. There are no material outstanding or unresolved comments received from the SEC.

 

(b)            As
of the date of this Agreement, the Common Stock is listed on The Nasdaq Global Market, and the Company has taken no action designed to,
or which to its knowledge is likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act or
delisting the Common Stock from The Nasdaq Global Market. As of the date of this Agreement, the Company has not received any notification
that, and has no knowledge that, the SEC or The Nasdaq Stock Market LLC is contemplating terminating such listing or registration. The
Shares, when issued, will be listed on The Nasdaq Global Market.

 

    	 	7	 

     

    

 

(c)            The
financial statements of the Company included in the Company SEC Documents, comply as to form in all material respects with applicable
accounting requirements and the published rules and regulations of the SEC with respect thereto, have been prepared in accordance
with United States generally accepted accounting principles applied on a consistent basis during the periods involved (except (i) as
may be indicated in the notes thereto or (ii) in the case of unaudited interim statements, to the extent they may not include footnotes
or may be condensed or summary statements) and fairly present in all material respects the financial position of the Company as of the
dates thereof and the results of its operations and cash flows for the periods then ended. Except (i) as set forth in the Company
SEC Documents or (ii) for liabilities incurred in the ordinary course of business subsequent to the date of the most recent balance
sheet contained in the Company SEC Documents, the Company has no liabilities, whether absolute or accrued, contingent or otherwise, other
than those that would not, individually or in the aggregate, have or be reasonably likely to have a Material Adverse Effect. There are
no material unconsolidated subsidiaries of the Company or any material off-balance sheet arrangements of any type (including any off-balance
sheet arrangement required to be disclosed pursuant to Item 303(a)(4) of Regulation S-K promulgated under the Securities Act) that
have not been so described in the SEC Documents filed prior to the date hereof nor any obligations to enter into any such arrangements.

 

4.11            Absence
of Certain Changes.

 

(a)            Except
as disclosed in the Company SEC Documents filed prior to the date hereof, since December 31, 2021, each of Company and its subsidiaries
has conducted its business operations in the ordinary course of business consistent with past practice, and there has not occurred any
event, change, development, occurrence, circumstance or condition that, individually or in the aggregate, has had or would reasonably
be expected to cause a Material Adverse Effect.

 

(b)            Except
as disclosed in the Company SEC Documents filed prior to the date hereof, since December 31, 2021, the Company has not (i) declared
or paid any dividends, or authorized or made any distribution upon or with respect to any class or series of its capital stock, or (ii) sold,
exchanged or otherwise disposed of any of its material assets or rights.

 

(c)            Since
December 31, 2021, the Company has not admitted in writing its inability to pay its debts generally as they become due, filed or
consented to the filing against it of a petition in bankruptcy or a petition to take advantage of any insolvency act, made an assignment
for the benefit of creditors, consented to the appointment of a receiver for itself or for the whole or any substantial part of its property,
or had a petition in bankruptcy filed against it, been adjudicated a bankrupt, or filed a petition or answer seeking reorganization or
arrangement under the federal bankruptcy laws or any other laws of the United States or any other jurisdiction.

 

4.12            No
Undisclosed Material Liabilities. The Company and its subsidiaries do not have any liabilities or obligations of any nature (whether
accrued, absolute, contingent or otherwise), except for liabilities or obligations (a) reflected or reserved against on the most
recent consolidated balance sheet of the Company included in the SEC Documents, (b) incurred since the date of such consolidated
balance sheet in the ordinary course of business or (c) that are not material to the Company and its subsidiaries taken as a whole.

 

    	 	8	 

     

    

 

4.13            Offering.
Subject to the accuracy of the Investor’s representations set forth in Sections 5.5, 5.6, 5.7, 5.8, 5.9 and 5.10, the offer, sale
and issuance of the Shares to be issued in conformity with the terms of this Agreement constitute transactions which are exempt from
the registration requirements of the Securities Act and from all applicable state registration or qualification requirements. Neither
the Company nor any Person acting on its behalf will take any action that would cause the loss of such exemption.

 

4.14            No
Integration. The Company has not, directly or through any agent, sold, offered for sale, solicited offers to buy or otherwise negotiated
in respect of, any security (as defined in the Securities Act) which is or will be integrated with the Shares sold pursuant to this Agreement
in a manner that would require the registration of the Shares under the Securities Act.

 

4.15            Brokers’
or Finders’ Fees. No broker, finder, investment banker or other Person is entitled to any brokerage, finder’s or other
fee or commission from the Company in connection with the transactions contemplated by the Transaction Agreements.

 

4.16            Internal
Controls; Disclosure Controls and Procedures. The Company maintains internal control over financial reporting as defined in Rule 13a-15(f) under
the Exchange Act. The Company has implemented the “disclosure controls and procedures” (as defined in Rules 13a-15(e) and
15d-15(e) under the Exchange Act) required in order for the principal executive officer and principal financial officer of the Company
to engage in the review and evaluation process mandated by the Exchange Act, and is in compliance with such disclosure controls and procedures
in all material respects. Each of the principal executive officer and the principal financial officer of the Company has made all certifications
required by Sections 302 and 906 of the Sarbanes-Oxley Act of 2002 with respect to all reports, schedules, forms, statements and other
documents required to be filed by the Company with the SEC.

 

4.17            Not
an Investment Company. The Company is not, and solely after receipt of the Aggregate Purchase Price, will not be, an “investment
company” as defined in the Investment Company Act of 1940, as amended.

 

4.18            Regulation
M Compliance. The Company has not, and to its knowledge no one acting on its behalf has, taken, directly or indirectly, any action
designed to cause or to result in the stabilization or manipulation of the price of any security of the Company to facilitate the sale
or resale of any of the Shares in violation of Regulation M under the Exchange Act.

 

5.            Representations
and Warranties of the Investor. The Investor hereby represents and warrants to the Company, that:

 

5.1            Organization.
The Investor is a corporation organized under the laws of The Commonwealth of Massachusetts.

 

5.2            Authorization.
All requisite action on the part of the Investor and its directors and stockholders, required by applicable Law for the authorization,
execution and delivery by the Investor of the Transaction Agreements, and the performance of all of its obligations thereunder, including
the subscription for and purchase of the Shares, has been taken. The Transaction Agreements have been duly executed and delivered by
the Investor and upon the due execution and delivery thereof by the Company, will constitute valid and legally binding obligations of
the Investor, enforceable against the Investor in accordance with their respective terms (except as such enforceability may be limited
by (i) applicable bankruptcy, insolvency, reorganization, moratorium or other Laws of general application relating to or affecting
enforcement of creditors’ rights and (ii) rules of Law governing specific performance, injunctive relief or other equitable
remedies and limitations of public policy).

 

    	 	9	 

     

    

 

5.3            No
Conflicts. The execution, delivery and performance of the Transaction Agreements, and compliance with the provisions hereof and thereof,
by the Investor do not and shall not: (a) violate any provision of applicable Law or any ruling, writ, injunction, order, permit,
judgment or decree of any Governmental Authority, (b) constitute a breach of, or default under (or an event which, with notice or
lapse of time or both, would become a default under) or conflict with, or give rise to any right of termination, cancellation or acceleration
of, any agreement, arrangement or instrument, whether written or oral, by which the Investor or any of its assets, are bound, or (c) violate
or conflict with any of the provisions of the Investor’s organizational documents (including any articles or memoranda of organization
or association, charter, bylaws or similar documents), except as would not have or be reasonably likely to materially adversely affect
the ability of the Investor to consummate the Transactions and perform its obligations under the Transaction Agreements.

 

5.4            No
Governmental Authority or Third Party Consents. No consent, approval, authorization or other order of any Governmental Authority
or other Third Party is required to be obtained by the Investor in connection with the authorization, execution and delivery of the Transaction
Agreements, or with the subscription for and purchase of the Shares, except as required pursuant to the HSR Act.

 

5.5            Investor
Entirely for Own Account. The Shares shall be acquired for the Investor’s own account, not as a nominee or agent, and not with
a present view to the resale or distribution of any part thereof, and the Investor has no present intention of selling, granting any
participation in or otherwise distributing the Shares. The Investor does not presently have any contract, undertaking, agreement or arrangement
with any Person to sell, transfer or grant participation to a Person any of the Shares.

 

5.6            Disclosure
of Information. The Investor has received all the information from the Company and its management that the Investor considers necessary
or appropriate for deciding whether to purchase the Shares hereunder. The Investor further represents that it has had an opportunity
to ask questions and receive answers from the Company regarding the Company, its financial condition, results of operations and prospects
and the terms and conditions of the offering of the Shares sufficient to enable it to evaluate its investment. The foregoing, however,
does not modify, amend or affect the Investor’s right to rely on the truth, accuracy and completeness of the Company SEC Documents,
or limit or modify the representations and warranties of the Company in Section 4 of this Agreement, or the right of the
Investor to rely thereon.

 

    	 	10	 

     

    

 

5.7            Investment
Experience and Accredited Investor Status. The Investor is an “accredited investor” (as defined in Regulation D under
the Securities Act). The Investor has such knowledge and experience in financial or business matters that it is capable of evaluating
the merits and risks of the investment in the Shares to be purchased hereunder.

 

5.8            Acquiring
Person. As of the date of this Agreement and immediately prior to the Closing, neither the Investor nor any of its Affiliates beneficially
owns, or will beneficially own (as determined pursuant to Rule 13d-3 under the Exchange Act without regard for the number of days
in which a Person has the right to acquire such beneficial ownership, and without regard to Investor’s rights under this Agreement),
any securities of the Company, except for securities that may be owned by employee benefit plans of the Investor or its Affiliates in
the ordinary course of business.

 

5.9            Restricted
Securities. The Investor understands that the Shares, when issued, will be “restricted securities” under the federal
securities Laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under
such Laws the Shares may be resold without registration under the Securities Act only in certain limited circumstances.

 

5.10            Legends.
The Investor understands that any certificates or book-entries representing the Shares shall bear the following legends:

 

“These securities have
not been registered under the Securities Act of 1933. They may not be sold, offered for sale, pledged or hypothecated in the absence
of a registration statement in effect with respect to the securities under the Securities Act or an opinion of counsel (which counsel
shall be reasonably satisfactory to Entrada Therapeutics, Inc.) that such registration is not required or unless sold pursuant to
Rule 144 of the Securities Act.”; and any legend required by applicable state securities Laws.

 

5.11            Financial
Assurances. As of the date hereof and as of the Closing Date, the Investor has and will have access to cash in an amount sufficient
to pay to the Company the Aggregate Purchase Price.

 

6.            Investor’s
Conditions to Closing. The Investor’ obligation to purchase the Shares at the Closing is subject to the fulfillment as of such
Closing of the following conditions (unless waived in writing by the Investor):

 

6.1            Transfer
Agent Instructions. The Company will have delivered to its transfer agent irrevocable written instructions to issue the Shares to
the Investor on the Closing Date in a form and substance acceptable to such transfer agent.

 

6.2            Representations
and Warranties. The representations and warranties made by the Company in Section 4 hereof shall be true and correct as of the
date of this Agreement and as of the Closing Date as though made on and as of such Closing Date, except to the extent such representations
and warranties are specifically made as of a particular date, in which case such representations and warranties shall be true and correct
as of such date; provided, however, that for purposes of this Section 6.2, all such representations and warranties
of the Company (other than Sections 4.1, 4.2(a), 4.3, 4.4, 4.5(a), and 4.8 of this Agreement) shall be deemed to be true and correct
for purposes of this Section 6.2 unless the failure or failures of such representations and warranties to be so true and correct,
without regard to any “material,” “materiality” or “Material Adverse Effect” qualifiers set forth
therein, individually or in the aggregate, has had or would reasonably be expected to have a Material Adverse Effect.

 

    	 	11	 

     

    

 

6.3            Covenants.
All covenants and agreements contained in this Agreement to be performed or complied with by the Company on or prior to the Closing Date
shall have been performed or complied with in all material respects.

 

6.4            No
Material Adverse Effect. From and after the date of this Agreement until the Closing Date, there shall have occurred no event that
has caused or would reasonably be expected to cause a Material Adverse Effect.

 

6.5            Listing.
The Shares shall be eligible for listing on The Nasdaq Global Market.

 

6.6            License
Agreement. The Effective Date (as such term is defined in the License Agreement) shall have occurred.

 

6.7            Closing
Deliverables. All closing deliverables as required under Section 3.2(a) shall have been delivered by the Company
to the Investor.

 

7.            Company’s
Conditions to Closing. The Company’s obligation to issue and sell the Shares at the Closing is subject to the fulfillment as
of such Closing of the following conditions (unless waived in writing by the Company):

 

7.1            Representations
and Warranties. The representations and warranties made by the Investor in Section 5 hereof shall be true and correct as of
the date of this Agreement and as of the Closing Date as though made on and as of such Closing Date, except to the extent such representations
and warranties are specifically made as of a particular date, in which case such representations and warranties shall be true and correct
as of such date.

 

7.2            Covenants.
All covenants and agreements contained in this Agreement to be performed or complied with by the Investor on or prior to the Closing
Date shall have been performed or complied with in all material respects.

 

7.3            Closing
Deliverables. All closing deliverables as required under Section 3.2(b) shall have been delivered by the Investor to the
Company.

 

8.            Mutual
Conditions to Closing. The obligations of the Investor and the Company to consummate the Closing are subject to the fulfillment as
of the Closing Date of the following conditions:

 

8.1            Absence
of Litigation. There shall be no action, suit, proceeding or investigation by a Governmental Authority pending or currently threatened
in writing against the Company or the Investor that questions the validity of any of the Transaction Agreements, the right of the Company
or the Investor to enter into any Transaction Agreement or to consummate the transactions contemplated hereby or thereby or which, if
determined adversely, would impose substantial monetary damages on the Company or the Investor as a result of the consummation of the
transactions contemplated by any Transaction Agreement.

 

    	 	12	 

     

    

 

8.2            HSR
Act. The filings required under the HSR Act in connection with the Transaction Agreements, as applicable, shall have been made and
the required waiting period shall have expired or been terminated.

 

8.3            No
Prohibition. No provision of any applicable Law and no judgment, injunction (preliminary or permanent), order or decree that prohibits,
makes illegal or enjoins the consummation of the Transaction shall be in effect.

 

9.            Termination.

 

9.1            Ability
to Terminate. This Agreement may be terminated at any time (the effective date of such termination, which shall be no sooner than
three (3) Business Days after notice of such termination, the “Termination Date”) prior to the Closing by:

 

(a)            mutual
written consent of the Company and the Investor;

 

(b)            either
the Company or the Investor, upon written notice to the other, if any of the mutual conditions to the Closing set forth in Section 8
shall have become incapable of fulfillment by the Termination Date and shall not have been waived in writing by the other party; provided,
however, that the right to terminate this Agreement under this Section 9.1(b) shall not be available to any party whose
failure to fulfill any obligation under this Agreement has been the cause of, or resulted in, the failure to consummate the transactions
contemplated hereby prior to the Termination Date;

 

(c)            the
Company, upon written notice to the Investor, so long as the Company is not then in breach of its representations, warranties, covenants
or agreements under this Agreement such that any of the conditions set forth in Section 7. could not be satisfied by the Termination
Date, (i) upon a breach of any covenant or agreement on the part of the Investor set forth in this Agreement, or (ii) if any
representation or warranty of the Investor shall have been or become untrue, in each case such that any of the conditions set forth in
Section 7, could not be satisfied by the Termination Date;

 

(d)            the
Investor, upon written notice to the Company, so long as the Investor is not then in breach of its representations, warranties, covenants
or agreements under this Agreement such that any of the conditions set forth in Section 6 could not be satisfied by the Termination
Date, (i) upon a breach of any covenant or agreement on the part of the Company set forth in this Agreement, or (ii) if any
representation or warranty of the Company shall have been or become untrue, in each case such that any of the conditions set forth in
Section 6, could not be satisfied by the Termination Date.

 

9.2            Automatic
Termination. In the event that the License Agreement is terminated prior to the Effective Date thereof (as such term is defined in
the License Agreement), this Agreement shall terminate automatically.

 

    	 	13	 

     

    

 

9.3            Effect
of Termination. In the event of the termination of this Agreement pursuant to Section 9.1 or Section 9.2 hereof, (a) this
Agreement (except for this Section 9.3 and Section 11 hereof (other than Section 11.13), and any definitions set forth
in this Agreement and used in such sections) shall forthwith become void and have no effect, without any liability on the part of any
party hereto or its Affiliates, and (b) all filings, applications and other submissions made pursuant to this Agreement, to the
extent practicable, shall be withdrawn from the agency or other Person to which they were made or appropriately amended to reflect the
termination of the transactions contemplated hereby; provided, however, that nothing contained in this Section 9.3
shall relieve any party from liability for fraud or any intentional or willful breach of this Agreement.

 

10.            Additional
Covenants and Agreements.

 

10.1            Standstill.

 

(a)            The
Investor hereby agrees that, unless otherwise agreed in writing by the Company, during the period commencing on the Closing Date and
ending on the fourth (4th) anniversary of the Closing Date, neither the Investor nor any of its Affiliates officers, directors,
employees, professional advisors or agents acting on the Investor’s behalf, will: (a) propose (i) any merger, consolidation,
business combination, tender or exchange offer, purchase of the Company’s assets or businesses, or similar transactions involving
the Company, (ii) any recapitalization, restructuring, liquidation or other extraordinary transaction with respect to the Company,
or (iii) knowingly encourage or support a tender, exchange or other offer or proposal by any Person except in the case of a tender
or exchange offer the acceptance of which has been recommended to the stockholders by the Board; (b) (i) acquire beneficial
ownership of any securities (including any additional securities of the Company or any instrument that gives the Investor or any of its
Affiliates the economic equivalent of ownership of an amount of securities of the Company (a “Derivative”)) of the
Company except in the ordinary course and for passive investment purposes up to nine point nine percent (9.9%) of the Company’s
then-outstanding Common Stock (collectively, a transaction specified in (a)(i), (a)(ii) and (b)(i) involving a majority of
the Company’s outstanding capital stock or consolidated assets, is referred to as a “Business Combination”),
(ii) propose or seek, whether alone or in concert with others, any “solicitation” (as such term is used in the rules of
the SEC) of proxies or consents to vote any securities (including any Derivatives) of the Company, (iii) nominate any Person as
a director of the Company, or (iv) propose any matter to be voted upon by the stockholders of the Company; (c) directly or
indirectly, form, join or in any way participate in a third party “group” (as such term is used in Section 13(d)(3) of
the Exchange Act) (or discuss with any third party the potential formation of a group) with respect to any securities (including any
Derivatives) of the Company or a Business Combination involving the Company; (d) take any action that would reasonably be expected
to require the Company to make a public announcement regarding a potential Business Combination; or (e) request or propose in writing
to the Board, any member(s) thereof or any officer of the Company that the Company amend, waive, or consider the amendment or waiver
of, any provisions set forth in this Section 10.1(a). Notwithstanding anything to the contrary provided in this Section 10.1,
the Investor and/or its Affiliates will not be restricted from (I) making a private, confidential proposal for a possible Business
Combination between itself and the Company solely to the Board so long as such confidential proposal would not require or reasonably
be expected to require (under applicable law, regulation or in connection with fiduciary obligations) the Company or its Board to make
any public disclosure or announcement regarding such communication, or (II) submitting to the Board or to the Chief Executive Officer
of the Company a confidential request or proposal for the Company to amend or waive, or consider the amendment or waiver of, any provisions
set forth in this Section 10.1(a), provided that neither the Company nor the Investor or any of its Affiliates is required to publicly
disclose the fact that such request or proposal was made.

 

    	 	14	 

     

    

 

(b)            Notwithstanding
anything contained herein to the contrary, it is understood and agreed that the Investor shall not be prohibited from entering into an
agreement and having discussions with legal, accounting or financial advisors for the limited purposes of evaluating any of the transactions
contemplated by this Section 10.1, and the Investor and/or its Affiliates will not be prohibited from the actions in clauses (a) through
(d) of Section 10.1(a) in the event that (i) the Company enters into a definitive agreement with a third party for
a transaction involving a Business Combination after the date of this Agreement, (ii) the Company sells all or substantially all
of its assets, (iii) a liquidation or dissolution of the Company occurs, (iv) any Person or Persons acting in concert shall
have announced or commenced a tender offer or exchange offer for more than fifty percent (50%) of the Company’s outstanding voting
securities, or (v) on and after the date that is twelve (12) months following the termination of the License Agreement. Neither
(y) the passive ownership nor purchase by an independently managed employee benefit plan of the Investor or its Affiliates of interests
in securities comprising part of a mutual fund or broad based, publicly traded market basket or index of stocks approved for such a plan
or trust in which such plan or trust invests, which fund, basket or index in-turn holds, directly or indirectly, securities of the Company,
or (z) the mere voting of the Shares in accordance with the terms of this Agreement, will be deemed to be a breach of the Investor’s
standstill obligations under this Section 10.1.

 

(c)            The
Investor’s standstill obligations outlined in this Section 10.1 shall supersede in all respects any standstill obligations
of the Investor in that certain confidentiality agreement between the Company and Investor, dated as of October 10, 2022.

 

10.2            Lock-Up.
During the period commencing on the Closing Date and ending on the second (2nd) anniversary of the Closing Date, without the
prior approval of the Board of the Company, the Investor shall not (i) offer, pledge, sell, contract to sell, sell any option or
contract to purchase, purchase any option or contract to sell, grant any option, right or warrant for the sale of, or otherwise dispose
of or transfer any Shares (together with (a) any shares of Common Stock issued in respect thereof as a result of any stock split,
stock dividend, share exchange, merger, consolidation or similar recapitalization and (b) any shares of Common Stock issued as (or
issuable upon the exercise of any warrant, right or other security that is issued as) a dividend or other distribution with respect to,
or in exchange or in replacement of, the Shares) (the “Lock-Up Securities”), including, without limitation, any “short
sale” or similar arrangement, or (ii) enter into any swap or any other agreement or any transaction that transfers, in whole
or in part, directly or indirectly, the economic consequence of ownership of the Shares, whether any such swap or transaction is to be
settled by delivery of securities, in cash or otherwise (the foregoing actions, collectively, a “Transfer”). Notwithstanding
the foregoing, during the period commencing on the eighteen (18) month anniversary of the Closing Date and ending on the second (2nd)
anniversary of the Closing Date, inclusive, without the prior approval of the Board of the Company, the Investor shall be permitted to
Transfer up to 50% of the Lock-Up Securities. Notwithstanding the foregoing, this Section 10.2 shall not prohibit the Investor or
its Affiliates from transferring Lock-Up Securities to an Affiliate of the Investor if such transferee Affiliate executes an agreement
with the Company to be bound by the restrictions set forth in Sections 10.1 and 10.2.

 

    	 	15	 

     

    

 

Notwithstanding
any other provision herein, this Section 10.2 shall not prohibit or restrict any disposition of Lock-Up Securities by the Investor
in connection with (i) a bona fide tender offer by a Person other than the Investor involving a Change of Control of the Company
(as defined below), which has not been rejected by the Company’s Board, (ii) an issuer tender offer by the Company, or (iii) the
Company’s public announcement of a definitive agreement to consummate an Acquisition Transaction. For the purposes of this Agreement,
a “Change of Control” means the transfer, in one transaction or a series of related transactions, as a result of which
any Person or group of Persons, other than the Company, (a) becomes the beneficial owner (as defined in Rules 13d-3 and 13d-5
of the Exchange Act) of more than 50% of total voting power of the voting securities of the Company or (b) completes a direct or
indirect acquisition or license of all or substantially all of the assets of the Company.

 

10.3            Market
Listing. From the date hereof through the Closing Date, Company shall use all reasonable efforts to (a) maintain the listing
and trading of the Common Stock on The Nasdaq Global Market and (b) effect the listing of the Shares on The Nasdaq Global Market,
including submitting the LAS to The Nasdaq Stock Market LLC no later than fifteen (15) calendar days prior to the Closing Date.

 

10.4            Assistance
and Cooperation. Prior to the Closing, upon the terms and subject to the conditions set forth in this Agreement and in accordance
with Section 4.8.1 and 4.8.2 of the License Agreement, as applicable, each of the parties agrees to use all reasonable efforts to
take, or cause to be taken, all actions and to do, or cause to be done, and to assist and cooperate with the other party in doing, all
things necessary, proper or advisable to consummate and make effective, in the most expeditious manner practicable, the transactions
contemplated by this Agreement, including using all reasonable efforts to accomplish the following: (a) taking all reasonable acts
necessary to cause the conditions precedent set forth in Sections 6, 7 and 8 to be satisfied (including, in the case of the Company,
promptly notifying the Investor of any notice from The Nasdaq Stock Market LLC with respect to the LAS); (b) taking all reasonable
actions necessary to obtain all necessary actions or non-actions, waivers, consents, approvals, orders and authorizations from Governmental
Authorities and the making of all necessary registrations, declarations and filings (including registrations, declarations and filings
with Governmental Authorities, if any); and (c) taking reasonable steps to obtain all necessary consents, approvals or waivers from
Third Parties.

 

10.5            Rule 144
Reporting. For as long as Investor or any of its Affiliates beneficially owns any Shares, to the extent it shall be required to do
so under the Exchange Act, Company shall use its reasonable best efforts to timely file the reports required to be filed by it under
the Exchange Act or the Securities Act (including reports under Sections 13 and 15(d) of the Exchange Act referred to in subparagraph
(c)(1) of Rule 144), and shall use commercially reasonable efforts to take such further necessary action as the Investor may
reasonably request in connection with the removal of any restrictive legend on the Shares being sold, all to the extent required from
time to time to enable Investor to sell the Shares without registration under the Securities Act within the limitations of the exemption
provided by Rule 144, provided that in connection therewith the Company (i) shall not be required to take any action that would
not be in compliance with applicable law, including, without limitation, the Securities Act, and (ii) may require the Investor to
execute such documentation as is reasonably satisfactory to the Company.

 

    	 	16	 

     

    

 

10.6            Voting
Agreement.

 

(a)              From
and after the Closing Date and ending on the earliest to occur of (i) the fourth (4th) anniversary of the Closing Date,
(ii) the consummation of a Change of Control of the Company, (iii) the liquidation or dissolution of the Company or (iv) the
date on which the Common Stock ceases to be registered pursuant to Section 12 of the Exchange Act, other than as permitted by Section 10.6(d) with
respect to Extraordinary Matters, if the Investor and/or its Affiliates shall collectively beneficially own securities of the Company
representing at least five percent (5%) of the Company’s Common Stock (as calculated pursuant to Rule 13d-3 of the Securities
Act), then in any vote or action by written consent of the stockholders of the Company (including, without limitation, with respect to
the election of directors), the Investor shall, and shall cause its Affiliates to, vote or execute a written consent with respect to
all voting securities of the Company as to which they are entitled to vote or execute a written consent in accordance with the recommendation
of the Board.

 

(b)              In
furtherance of this Section 10.6, the Investor hereby irrevocably appoints the Company and any individuals designated by the Company,
and each of them individually, as the attorneys, agents and proxies, with full power of substitution and re-substitution in each of them,
for the Investor, and in the name, place and stead of the Investor, to vote (or cause to be voted) or, if applicable, to give consent,
in such manner as each such attorney, agent and proxy or his substitute shall in its, his or her sole discretion deem appropriate or
desirable with respect to such matters as set forth in Section 10.6(a) with respect to all voting securities (whether taking
the form of Common Stock or other voting securities of the Company) with respect to which the Investor is or may be entitled to vote
at any meeting of the Company held after the date hereof, whether annual or special and whether or not an adjourned meeting or, if applicable,
to give written consent with respect thereto (the “Irrevocable Proxy”). This Irrevocable Proxy is coupled with an
interest, shall be irrevocable and binding on any successor in interest of the Investor and shall not be terminated by operation of law
upon the occurrence of any event. This Irrevocable Proxy shall operate to revoke and render void any prior proxy as to voting securities
of the Company heretofore granted by the Investor which is inconsistent herewith. Notwithstanding the foregoing, the Irrevocable Proxy
shall be effective if, at any annual or special meeting of the stockholders of the Company (or any consent in lieu thereof) and at any
adjournments or postponements of any such meetings, the Investor (A) fails to appear or otherwise fails to cause its voting securities
of the Company to be counted as present for purposes of calculating a quorum, or (B) fails to vote such voting securities in accordance
with Section 10.6(a), in each case at least five (5) Business Days prior to the date of such stockholders’ meeting (or
within five (5) Business Days prior to the effective time of an action to be taken by written consent in lieu of such stockholders’
meeting). The Irrevocable Proxy shall terminate upon the earlier of the expiration or termination of the voting agreement set forth in
Section 10.6(a).

 

    	 	17	 

     

    

 

(c)            The
Investor shall cause any controlled Affiliate of the Investor that may from time to time own of record (or the record holder holding
on behalf of such controlled Affiliate if owned beneficially) voting securities of the Company (whether taking the form of Common Stock
or other voting securities of the Company), if and when requested by the Company from time to time, to promptly execute and deliver to
the Company an irrevocable proxy, substantially in the form of Exhibit D attached hereto, and irrevocably appoint the Company
and any individuals designated by the Company, and each of them individually, with full power of substitution and resubstitution, as
its attorney, agent and proxy to vote (or cause to be voted) or to give consent with respect to, all of the voting securities of the
Company as to which such controlled Affiliate is entitled to vote, in such manner as each such attorney, agent and proxy or his substitute
shall in its, his or her sole discretion deem appropriate or desirable with respect to the matters set forth in this Section 10.6
(the “Affiliate Irrevocable Proxy”). The Investor acknowledges, and shall cause its controlled Affiliates to acknowledge,
that any such proxy executed and delivered shall be coupled with an interest, shall constitute, among other things, an inducement for
the Company to enter into this Agreement, shall be irrevocable and binding on any successor in interest of such controlled Affiliate
and shall not be terminated by operation of Law upon the occurrence of any event. Such proxy shall operate to revoke and render void
any prior proxy as to any voting securities of the Company heretofore granted by such controlled Affiliate, to the extent it is inconsistent
herewith. The Investor acknowledges and agrees that it shall be a condition to any proposed transfer of voting securities of the Company
by the Investor to such controlled Affiliate that such controlled Affiliate execute and deliver to the Company an Affiliate Irrevocable
Proxy, and that any purported transfer shall be void and of no force or effect if such Affiliate Irrevocable Proxy is not so executed
and delivered at the closing of such transfer. Such proxy shall terminate upon the earlier of the expiration or termination of the voting
agreement set forth in this Section 10.6.

 

(d)            The
Investor and its controlled Affiliates may vote, or execute a written consent with respect to, any or all of the voting securities of
the Company as to which they are entitled to vote or execute a written consent, as they may determine in their sole discretion, with
respect to the following matters (each such matter being an “Extraordinary Matter”):

 

(i)            any
transaction which would result in a Change of Control of the Company;

 

(ii)            any
issuance of Common Stock that represents more than 20% of the then outstanding Common Stock;

 

(iii)            the
entry into any licensing, partnership, collaboration, research and development, joint venture or other commercial agreement; and

 

(iv)            any
liquidation or dissolution of the Company.

 

(e)            For
so long as the voting agreement set forth in this Section 10.6 is in effect, the Investor shall be, and shall cause each of its
controlled Affiliates to be, present in person or represented by proxy at all meetings of stockholders to the extent necessary so that
all voting securities of the Company as to which they are entitled to vote shall be counted as present for the purpose of determining
the presence of a quorum at such meeting.

 

    	 	18	 

     

    

 

11.            Miscellaneous.

 

11.1            Governing
Law; Submission to Jurisdiction. This Agreement shall be governed by and construed in accordance with the Laws of the State of Massachusetts,
without regard to the conflict of laws principles thereof that would require the application of the Law of any other jurisdiction.

 

11.2            Waiver.
Waiver by a party of a breach hereunder by the other party shall not be construed as a waiver of any subsequent breach of the same or
any other provision. No delay or omission by a party in exercising or availing itself of any right, power or privilege hereunder shall
preclude the later exercise of any such right, power or privilege by such party. No waiver shall be effective unless made in writing
with specific reference to the relevant provision(s) of this Agreement and signed by a duly authorized representative of the party
granting the waiver.

 

11.3            Notices.
All notices, instructions and other communications hereunder or in connection herewith shall be in writing, shall be sent to the address
of the relevant party set forth on Exhibit B attached hereto, or at such other address as such party may designate by ten
(10) days’ advance written notice to the other party, and shall be deemed effectively given: (i) upon personal delivery
to the party to be notified; (ii) when sent by confirmed e-mail if sent during normal business hours of the recipient, and if not
during normal business hours of the recipient, then on the next Business Day; (iii) five (5) calendar days after having been
sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) Business Day after deposit
with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. Either party may
change its address by giving notice to the other party in the manner provided above.

 

11.4            Entire
Agreement. This Agreement and the License Agreement (including any schedules and exhibits hereto and thereto) contain the entire
agreement among the parties with respect to the subject matter hereof and thereof and supersede all prior and contemporaneous arrangements
or understandings, whether written or oral, with respect hereto and thereto.

 

11.5            Amendments.
No provision in this Agreement shall be supplemented, deleted or amended except in a writing executed by an authorized representative
of each of the Investor and the Company.

 

11.6            Headings;
Nouns and Pronouns; Section References. Headings in this Agreement are for convenience of reference only and shall not be considered
in construing this Agreement. Whenever the context may require, any pronouns used herein shall include the corresponding masculine, feminine
or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. References in this Agreement to
a section or subsection shall be deemed to refer to a section or subsection of this Agreement unless otherwise expressly stated.

 

11.7            Severability.
If any provision hereof is invalid, illegal or unenforceable in any jurisdiction, then, the parties will use commercially reasonable
efforts to find and employ a valid, legal and enforceable substitute provision that most nearly reflects the original intent of the parties
and all other provisions hereof will remain in full force and effect in such jurisdiction and will be liberally construed in order to
carry out the intentions of the parties hereto as nearly as may be possible. Such invalidity, illegality or unenforceability will not
affect the validity, legality or enforceability of such provision in any other jurisdiction.

 

    	 	19	 

     

    

 

11.8            Assignment.
Except for an assignment by the Investor of this Agreement or any rights hereunder to an Affiliate (which assignment will not relieve
the Investor of any obligation hereunder), neither this Agreement nor any of the rights or obligations hereunder may be assigned by either
the Investor or the Company without (a) the prior written consent of the Company in the case of any assignment by the Investor or
(b) the prior written consent of the Investor in the case of an assignment by the Company.

 

11.9            Successors
and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors
and permitted assigns.

 

11.10            Counterparts.
This Agreement may be executed in counterparts, each of which shall be deemed an original but which together shall constitute one and
the same instrument. Counterparts may be delivered via electronic mail (including .pdf or any electronic signature) or other transmission
method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.

 

11.11            Third
Party Beneficiaries. None of the provisions of this Agreement shall be for the benefit of or enforceable by any Third Party, including
any creditor of any party hereto, except that each Affiliate of the Investor is an express third party beneficiary entitled to enforce
this agreement directly against the Company. No Third Party shall obtain any right under any provision of this Agreement or shall by
reason of any such provision make any claim in respect of any debt, liability or obligation (or otherwise) against any party hereto.

 

11.12            No
Strict Construction. This Agreement has been prepared jointly and will not be construed against either party.

 

11.13            Survival
of Warranties. The representations and warranties of the Company and the Investor contained in this Agreement shall survive the Closing
for eighteen (18) months, except for (a) the representations and warranties set forth in Sections 4.1, 4.2, 4.4, 4.5(a), 4.6(d),
4.8, 4.12, 5.1, 5.2, 5.3(c), 5.5, 5.7, 5.8, 5.9 and 5.10, which shall survive forever and (b) the representation and warranty of
the Investor in Section 5.11, which shall not survive the Closing. The parties hereby acknowledge and agree that the rights of the
parties hereunder are special, unique and of extraordinary character, and that if any party refuses or otherwise fails to act, or to
cause its Affiliates to act, in accordance with the provisions of this Agreement, such refusal or failure would result in irreparable
injury to the Company or the Investor as the case may be, the exact amount of which would be difficult to ascertain or estimate and the
remedies at law for which would not be reasonable or adequate compensation. Accordingly, if any party refuses or otherwise fails to act,
or to cause its Affiliates to act, in accordance with the provisions of this Agreement, then, in addition to any other remedy which may
be available to any damaged party at law or in equity, such damaged party will be entitled to seek specific performance and injunctive
relief, without posting bond or other security, and without the necessity of proving actual or threatened damages, which remedy such
damaged party will be entitled to seek in any court of competent jurisdiction.

 

    	 	20	 

     

    

 

11.14            Remedies.
The rights, powers and remedies of the parties under this Agreement are cumulative and not exclusive of any other right, power or remedy
which such parties may have under any other agreement or Law. No single or partial assertion or exercise of any right, power or remedy
of a party hereunder shall preclude any other or further assertion or exercise thereof.

 

11.15            Expenses.
Each party shall pay its own fees and expenses in connection with the preparation, negotiation, execution and delivery of the Transaction
Agreements.

 

11.16            Public
Announcement. On a date to be determined by the Investor, the parties will jointly issue a press release in a mutually agreed form
(which press release may be combined with the press release contemplated by the License Agreement to be issued upon execution by the
License Agreement) and the Company will file with the SEC a Form 8-K in substantially the form attached hereto as Exhibit C,
regarding the signing of the Transaction Agreements (collectively, the “Agreed Disclosures”). Each of the parties
agrees that, other than the Agreed Disclosures or as permitted by the immediately succeeding sentence, except as may be required by law,
rule, regulation or the requirements of any self-regulatory organization or stock exchange listing requirements (in which case the party
required to make the filing, disclosure, communication, release or announcement shall provide the other party a reasonable opportunity
to review such filing, disclosure, communication, release or announcement and shall reasonably consider the other party’s comments
regarding confidential treatment sought for such filing, disclosure, communication, release or announcement), and as reasonably required
by either party for its corporate communications, including corporate presentations and corporate website, each of the parties hereto
will not make any public statement, press release or other public filing, disclosure, communication, release, or announcement with respect
to this Agreement and any of the transactions contemplated by the Transaction Agreements without the prior written approval of the other
party; provided, that nothing herein shall limit or prevent a party from making any statements, press releases or other filings, disclosures,
communications, releases or announcements to the extent reasonably related to such party exercising or enforcing any of its rights under
this Agreement. For clarity, either party may make subsequent public announcement regarding the Transaction Agreements or activities
hereunder or thereunder that has already been approved by the other party without the need to obtain additional written approval of the
other party provided that such subsequent public announcement remains correct at such time.

 

(Signature Page Follows)

 

    	 	21	 

     

    

 

IN WITNESS WHEREOF, the parties have executed
and delivered this Agreement as of the date first above written.

 

	 	ENTRADA THERAPEUTICS, INC.
	 	 
	 	By:	/s/ Dipal
    Doshi
	 	 	Name:	Dipal Doshi
	 	 	Title:	President and Chief Executive Officer

 

	 	VERTEX PHARMACEUTICALS INCORPORATED
	 	 
	 	By:	 /s/ Reshma Kewalramani
	 	 	Name:	Reshma Kewalramani
	 	 	Title:	Chief Executive Officer and President

 

Signature Page to
Stock Purchase Agreement

 

     

     

    

 

EXHIBIT A

FORM OF CROSS RECEIPT

 

    	 	A-1	 

     

    

 

EXHIBIT B

NOTICES

 

    	 	B-1	 

     

    

 

EXHIBIT C

FORM OF 8-K

 

    	 	C-1	 

     

    

 

EXHIBIT D

FORM OF
IRREVOCABLE PROXY

 

    	 	D-1

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