Document:

EX-10.4

 Exhibit 10.4 

Execution Version 

SECOND AMENDMENT TO 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This SECOND AMENDMENT TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the “Amendment”) is entered into by and
between MEDNAX SERVICES, INC., a Florida corporation (“Employer”), and Dominic J. Andreano (“Employee”) on July 12, 2020, and shall be effective as such date (“Effective Date”). 

RECITALS 
 WHEREAS,
Employer and Employee are the parties to that certain Amended and Restated Employment Agreement, effective as of February 13, 2020, as amended by that certain First Amendment to Amended and Restated Employment Agreement, effective April 1,
2020 (collectively, the “Employment Agreement”); 
 WHEREAS, Employer acknowledges that Employee has the basis to terminate
Employee’s employment for “Good Reason” pursuant to Section 4.7 of the Employment Agreement as a result of Roger J. Medel, M.D. no longer being the senior most executive officer of MEDNAX; and 

WHEREAS, in the event that Employee terminates Employee’s employment for “Good Reason” pursuant to Section 4.7 of
the Employment Agreement, Employee is entitled to certain severance benefits, including the accelerated vesting of all Equity Awards granted to Employee by MEDNAX prior to the Effective Date, in each case subject to the terms of the Employment
Agreement; and 
 WHEREAS, in exchange for Employer’s agreement to amend the Employment Agreement as provided in this Amendment,
Employee agrees not to provide written notice of termination of Employee’s employment under the Agreement for “Good Reason” prior to the sixtieth (60th) day after the Effective Date. 

NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein, Employer and Employee agree to the following:

 1.    All capitalized terms used but not otherwise defined in this Amendment have the meanings provided in the
Employment Agreement. 
 2.    Employee agrees not to provide Employer with written notice of termination of
Employee’s employment under the Agreement for “Good Reason” as contemplated by Section 4.7 of the Employment Agreement prior to the sixtieth (60th) day after the Effective
Date. Employee further agrees that if Employee elects to terminate Employee’s employment on or after the sixtieth (60th) day after the Effective Date for “Good Reason” as a result
of Roger J. Medel, M.D. no longer being the senior most executive officer of MEDNAX, then the effective date of such termination shall be the thirtieth (30th) day after the date of Employee’s
notice of termination, provided, however, Employer may, at its option, require Employee to terminate employment at any time in advance of the expiration of such thirty (30) day period. 

3.    The first sentence of Section 4.1 of the Employment Agreement is hereby deleted in its entirety and
replaced with the following: 

 “Employer may terminate Employee’s employment under this Agreement for Cause,
except during the ninety-one (91) day period beginning on the Effective Date of the Second Amendment to this Agreement.”. 

4.    Notwithstanding any contrary provision in the Employment Agreement or any Equity Plan then maintained by
MEDNAX, and in addition to any other payments or benefits provided in Article 5 of the Employment Agreement upon a termination of Employee’s employment pursuant to Section 4.7 of the Employment Agreement, all Equity Awards granted to
Employee by MEDNAX prior to the Effective Date shall become fully vested, non-forfeitable, and, if applicable, exercisable as of the Effective Date, subject to Employee’s timely execution and non-revocation of the general release to the Amendment as Exhibit A. 

5.    Except as specifically amended hereby, the Employment Agreement is and remains unmodified and in full force
and effect and is hereby ratified and confirmed. 
 6.    This Amendment shall be governed by and construed in
accordance with the terms and conditions of the Employment Agreement, including the governing law and dispute resolution provisions thereof. 

7.    This Amendment may be executed in counterparts and both of such counterparts shall for all purposes be deemed
to be an original, and such counterparts shall constitute one and the same instrument. The Amendment may be executed by facsimile or other electronic signature. 

[Remainder of page intentionally left blank; signatures follow on next page] 

  
 2 

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the Effective
Date. 
  

					
		 	MEDNAX SERVICES, INC.
			
		 	By:	 	 /s/ Cesar L. Alvarez

Name: Cesar L. Alvarez
 Title: Chairman of the Board,

MEDNAX, Inc.

		
		 	MEDNAX, INC.
			
		 	By:	 	 /s/ Cesar L. Alvarez

Name: Cesar L. Alvarez
 Title: Chairman of the Board

		
		 	EMPLOYEE:
		
		 	 /s/ Dominic J. Andreano

		 	Dominic J. Andreano

 [Signature Page to Second Amendment to Employment Agreement] 

 EXHIBIT A 

RELEASE 
 This Release
(the “Release”) is hereby made and entered into between MEDNAX SERVICES, INC. (“Employer”) and Dominic J. Andreano (“Employee”) to be effective as set forth in Section 7 below. Employee’s execution of this
Release is a condition to his receipt of the benefits pursuant to Section 4 of the Second Amendment to the Employment Agreement between Employer and Employee effective as of July 12, 2020 (the “Amendment”), to which this Release
is attached as Exhibit A. Any terms not defined herein shall have the meaning set forth in the Amendment or the Employment Agreement. 

1.    Release. 

(a)    Employee, for himself and his family, heirs, executors, administrators, legal representatives, and their respective
successors and assigns, in exchange for the consideration to be provided pursuant to Section 4 of the Amendment hereby gives up, releases, and discharges Employer, MEDNAX, Inc. and each of their subsidiaries, Affiliates, successors and assigns,
and their current and former directors, managers, officers, employees, shareholders and agents in such capacities (each a “Released Party” and, collectively with Employer and MEDNAX, Inc., the “Released Parties”) from any and all
rights and claims that Employee may have against the Released Parties as of the date Employee signs this Release arising from or in connection with Employee’s employment with Employer, including without limitation any and all rights and claims
to or for attorneys’ fees, whether or not Employee presently is aware of such rights or claims or suspects them to exist. These rights and claims include, but are not limited to, any and all rights and claims which Employee may have under, or
arising out of, the Age Discrimination in Employment Act of 1967, as amended (the “ADEA”); the Americans with Disabilities Act of 1990, as amended; the Family and Medical Leave Act; Title VII of the Civil Rights Act of 1964, as amended;
and any other federal, state, or local constitution, statute, ordinance, executive order, or common law. 

(b)    Notwithstanding anything in Paragraph 1(a) above to the contrary, this Release shall not apply to (i) any
actions to enforce rights to receive any payments or benefits which may be due to Employee pursuant to the Employment Agreement or under any of Employer’s employee benefit plans; (ii) any rights or claims that may arise as a result of
events occurring after the date this Release is signed by Employee; (iii) any indemnification rights Employee may have as a current or former officer or director of Employer or its Affiliates; (iv) any claims for benefits under any
directors’ or officers’ liability policy maintained by Employer or its Affiliates in accordance with the terms of such policy; (v) any rights Employee may have as a holder of equity securities of MEDNAX, including all vesting and
accelerated vesting rights as set forth in the Employment Agreement; (vi) any claims that cannot be waived as a matter of law; (vii) any claims Employee may have to government-sponsored and administered benefits such as unemployment
insurance, workers’ compensation insurance (excluding claims for retaliation under workers’ compensation laws), state disability insurance, and paid family leave benefits; (viii) any benefits that vested on or prior to the Effective
Date pursuant to a written benefit plan sponsored by Employer and governed by the federal law known as “ERISA”; and (ix) any claims with respect to Employee’s continued employment after the Effective Date. 

  
 A-1 

 (c)    Nothing in this Release prohibits or prevents Employee from
filing a charge with or participating, testifying, or assisting in any investigation, hearing, or other proceeding before the U.S. Equal Employment Opportunity Commission, the National Labor Relations Board or a similar agency enforcing federal,
state or local anti-discrimination laws (except that Employee acknowledges that he may not recover any monetary benefits or personal relief in connection therewith). Additionally, nothing in this Release prevents Employee from: (i) reporting
possible violations of federal law or regulations, including any possible securities laws violations, to any governmental agency or entity, including but not limited to the U.S. Department of Justice, the U.S. Securities and Exchange Commission, the
U.S. Congress, or any agency Inspector General; (ii) making any other disclosures that are protected under the whistleblower provisions of federal law or regulations; or (iii) otherwise fully participating in any federal whistleblower
programs, including but not limited to any such programs managed by the U.S. Securities and Exchange Commission and/or the Occupational Safety and Health Administration. Moreover, nothing in this Release prohibits or prevents Employee from
receiving individual monetary awards or other individual relief by virtue of participating in such federal whistleblower programs. 

2.    Employee Representations and Covenant Not to Sue. Employee represents that he has not filed against the
Released Parties any complaints, charges, or lawsuits arising out of his employment, termination of employment, or any other matter arising on or prior to the date Employee signed this Release, and covenants and agrees that he will never
individually or with any person or entity file, or commence the filing of, any charge, lawsuit, complaint, or proceeding with any governmental agency, or against the Released Parties with respect to any of the matters released by Employee pursuant
to Paragraph 1(a) hereof (a “Proceeding”); provided, however, Employee retains the right to commence a Proceeding to challenge whether Employee knowingly and voluntarily waived his rights under ADEA. If Employee does pursue a
legal claim or files an administrative charge that may not be released as a matter of law, or if such a claim or charge is brought on Employee’s behalf, Employee waives any right to recover any monetary payments or other individual benefits in
any such proceeding (except that, for purposes of clarity, this limitation on monetary recovery shall not apply to proceedings before the Securities and Exchange Commission or pursuant to other federal whistleblower claims). 

3.    Severability. If any provision of this Agreement, or any part thereof, is determined to be invalid or
unenforceable by a court having jurisdiction in the matter, all of the remaining provisions and parts of this Agreement shall remain fully enforceable; except that, if the provisions in Paragraph 1 concerning releases are held to be invalid,
illegal, or unenforceable, then Employee will be required to enter into a new Release with an enforceable release, unless otherwise agreed to in writing by all parties. 

4.    Consideration Period; Revocation Period. Employee hereby shall have
twenty-one (21) days to sign this Release, but he may knowingly and voluntarily waive that twenty-one (21) day period by signing this Release earlier. Employee
shall have seven (7) days following the date on which he signs this Release within which he may revoke it by providing a written notice of his revocation to the General Counsel of Employer. 

5.    Additional Employee Acknowledgement. Employee acknowledges that he has read this Release, that he has been
advised to consult with an attorney before he signs this Release, and that he understands all of its terms and signs it voluntarily and with full knowledge of its significance and the consequences thereof. 

  
 A-2 

 6.    Consideration. Employee acknowledges that the execution of
this Release is in further consideration of the payments due to Employee under Section 4 of the Amendment, which includes benefits to which Employee acknowledges he would not be entitled if he did not sign this Release. 

7.    Effective Date. This Release shall take effect on the eighth (8th) day following Employee’s signing it
unless Employee’s written revocation is delivered to the Chief Financial Officer of Employer within seven (7) days after Employee signs this Release, in which case this Release shall be null and void and of no legal effect. 

Employee provides this Release as of the current date. Employee intends that this Release become a binding agreement between Employee and Employer.

  

							
	EMPLOYER:	 		  	EMPLOYEE:
			
	MEDNAX SERVICES, INC.	 		  	
				
	 By:
  
	 	 /s/ Cesar L. Alvarez
	 		  	 /s/ Dominic J. Andreano

	Name:	 	Cesar L. Alvarez	 	            	  	Dominic J. Andreano
	Title:	 	Chairman of Board, MEDNAX, Inc.	 		  	
	Date:	 	July 12, 2020	 		  	Date:    July 12, 2020

  
 A-3Exhibit 10.1

EXECUTION VERSION

 

SHARE
PURCHASE AGREEMENT

 

This
SHARE Purchase Agreement (the “Agreement”) is made and entered into as of July 12, 2020 (the “Signing
Date”), by and between BeiGene, Ltd., an exempted company incorporated in the Cayman Islands (the “Company”),
and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser”
and collectively, the “Purchasers”).

 

WHEREAS, subject to
the terms and conditions set forth in this Agreement and pursuant to an effective registration statement under the Securities Act
of 1933, as amended (the “Securities Act”), the Company desires to issue and sell to each Purchaser, and each
Purchaser severally and not jointly, desires to purchase from the Company, such number of Ordinary Shares (as defined below) as
set forth below such Purchaser’s name on the signature page of this Agreement (which aggregate amount for all Purchasers
together shall be 145,838,979 Ordinary Shares, and shall be collectively referred to herein as the “Purchased Shares”)
at a purchase price of $14.2308 per Share for an aggregate purchase price of two billion seventy-five million four hundred and
five thousand three hundred and forty-two Dollars and thirty-five cents ($2,075,405,342.35) (the “Purchase Price”)
on the terms and conditions set forth herein.

 

WHEREAS, the Company
proposed, and its shareholders approved, an ordinary resolution at the 2020 annual general meeting on June 17, 2020 (the “2020
AGM”) to authorize the Company in its sole discretion to, in the Company’s securities offerings, allocate to Baker
Bros. Advisors LP (“Baker Bros”) and Hillhouse Capital Management, Ltd. (“Hillhouse”) and
the parties affiliated with each of them, up to a maximum amount of shares in order to maintain the same shareholding percentage
of each of them (based on then-outstanding share capital of the Company) before and after the allocation of the corresponding securities
issued pursuant to an offering conducted pursuant to the general mandate approved by the Company’s shareholders at the 2020
AGM to issue shares for a period of five years, which period will be subject to an extension on a rolling basis each year, subject
to the conditions specified in the Company’s proxy statement for the 2020 AGM (the “Connected Person Placing Authorization
I”).

 

WHEREAS, the Company
proposed, and its shareholders approved, an ordinary resolution at the 2020 AGM to authorize the Company in its sole discretion
to, in the Company’s securities offerings, allocate to Amgen Inc. (“Amgen”), up to a maximum amount of
shares in order to maintain the same shareholding percentage of Amgen (based on the then-outstanding share capital of the Company)
before and after the allocation of the corresponding securities issued pursuant to an offering conducted pursuant to the general
mandate approved by the Company’s shareholders at the 2020 AGM to issue shares for a period of five years, which period will
be subject to an extension on a rolling basis each year, subject to the conditions specified in the Company’s proxy statement
for the 2020 AGM (together with the Connected Person Placing Authorization I, the “Connected Person Placing Authorizations”).

 

WHEREAS, Baker Bros
and Amgen are connected persons (as defined under the HK Listing Rules (as defined below)) to the Company on the date hereof and
their subscriptions of the Purchased Shares shall therefore be subject to the Connected Person Placing Authorizations, in compliance
with the HK Listing Rules.

 

    1

     

    

 

WHEREAS, Hillhouse
is not a connected person to the Company on the date hereof and its subscription of the Purchased Shares shall not therefore be
subject to the Connected Person Placing Authorizations, for the purpose of complying with the HK Listing Rules.

 

NOW, THEREFORE, in
consideration of the foregoing recitals and the mutual promises, representations, warranties, and covenants hereinafter set forth
and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto
agree as follows:

 

1.                 
Definitions. When used in this Agreement, the following terms shall have the respective meanings
specified below:

 

“Action”
shall mean any action, cause or action, suit, prosecution, investigation, litigation, arbitration, hearing, order, claim, complaint
or other proceeding (whether civil, criminal, administrative, investigative or informal) by or before any Governmental Authority
or arbitrator.

 

“Affiliate”
shall mean, with respect to any Person, another Person which controls, is controlled by or is under common control with such Person.
A Person shall be deemed to control another Person if such Person possesses, directly or indirectly, the power to direct or cause
the direction of the management and policies of such Person, whether through the ownership of voting securities, by contract or
otherwise. For the purposes of this Agreement, in no event shall such Purchaser or any of its Affiliates be deemed Affiliates of
the Company or any of its Affiliates, nor shall the Company or any of its Affiliates be deemed Affiliates of such Purchaser or
any of its Affiliates.

 

“American
Depositary Receipts” shall mean the certificates issued by the Depositary evidencing the American Depositary Shares.

 

“American
Depositary Shares” shall mean shares issued by the Depositary pursuant to the Deposit Agreement, each representing 13
Ordinary Shares.

 

“beneficially
owns” (including the correlative terms “beneficial ownership,” “beneficially owned,”
 “beneficial owner” or “beneficially owning”) shall mean beneficial ownership within the meaning
of Rule 13d-3 and Rule 13d-5 under the Exchange Act.

 

“Business
Day” shall mean any day except Saturday, Sunday and any day on which banking institutions in New York, New York, generally
are closed as a result of federal, state or local holiday.

 

“Change of
Control” shall mean, with respect to a Person, any of the following events: (i) any Person is or becomes the beneficial
owner (as such term is defined in Rule 13d-3 under the Exchange Act, except that a Person shall be deemed to have beneficial ownership
of all shares that any such Person has the right to acquire, whether such right which may be exercised immediately or only after
the passage of time), directly or indirectly, of a majority of the total voting power represented by all shares of such Person’s
outstanding capital stock; (ii) such Person consolidates with or merges into another corporation or entity, or any corporation
or entity consolidates with or merges into such Person, other than (A) a merger or consolidation which would result in the voting
securities of such Person outstanding immediately prior to such merger or consolidation continuing to represent (either by remaining
outstanding or by being converted into voting securities of the surviving entity or any parent thereof) a majority of the combined
voting power of the voting securities of such Person or such surviving entity or any parent thereof outstanding immediately after
such merger or consolidation, or (B) a merger or consolidation effected to implement a recapitalization of such Person (or similar
transaction) in which no Person becomes the beneficial owner, directly or indirectly, of a majority of the total voting power
of all shares of capital stock of such Person, or (iii) such Person conveys, transfers or leases all or substantially all of its
assets, to any Person other than a wholly owned Affiliate of such Person.

 

    2

     

    

 

“Code”
shall mean the United States Internal Revenue Code of 1986, as amended.

 

“Consent”
shall mean any, internal or external, approval, authorization, consent, license, franchise, Order, registration, notification,
permit, certification, clearance, waiver or other confirmation of or by a Governmental Authority, other Person or company body.

 

“Contract”
shall mean, with respect to any Person, any written agreement, contract, commitment, indenture, note, bond, loan, license, sublicense,
lease, sublease, undertaking, statement of work or other arrangement to which such Person is a party or by which any of its properties
or assets are subject.

 

“control”
(including the correlative terms “controlled by,” “controlling,” and “under common
control with”), as applied to any Person, shall mean the possession, directly or indirectly, of the power to direct or
cause the direction of the management and policies of that Person, whether through the ownership or voting of securities, by contract
or otherwise.

 

“Deposit Agreement”
shall mean the Deposit Agreement, dated as of February 5, 2016, as amended from time to time, among the Company, the Depositary,
and holders from time to time of the American Depositary Receipts.

 

“Deposit Shares”
shall mean the American Depositary Shares into which the Purchased Shares may be exchanged upon deposit thereof with the Depositary
pursuant to the Deposit Agreement.

 

“Depositary”
shall mean Citibank, N.A.

 

“Disposition”
or “Dispose of” shall mean any (i) offer, pledge, sale, contract to sell, sale of any option or contract to
purchase, purchase of any option or contract to sell, grant of any option, right or warrant for the sale of, or other disposition
of or transfer of any Ordinary Shares, American Depositary Shares or Ordinary Share Equivalents, including, without limitation,
any “short sale” or similar arrangement, or (ii) swap, hedge, derivative instrument, or any other agreement or any
transaction that transfers, in whole or in part, directly or indirectly, the economic consequence of ownership of Ordinary Shares,
American Depositary Shares or Ordinary Share Equivalents, whether any such swap or transaction is to be settled by delivery of
securities, in cash or otherwise.

 

“Exchange
Act” shall mean the U.S. Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 

“GAAP”
shall mean generally accepted accounting principles in the United States.

 

    3

     

    

 

“Governmental
Authority” shall mean any court, agency, authority, department, regulatory body or other instrumentality of any government
or country or of any national, federal, state, provincial, regional, county, city or other political subdivision of any such government
or country or any supranational organization of which any such country is a member.

 

“Health Care
Laws” shall mean all applicable Laws relating to pricing, marketing, provision, sale, distribution, coverage, or reimbursement
of a drug, biological or medical device.

 

“HK Listing
Rules” shall mean the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited.

 

“HK Stock
Exchange” shall mean The Stock Exchange of Hong Kong Limited.

 

“Law”
or “Laws” shall mean all laws, statutes, rules, regulations, orders, judgments, injunctions and ordinances of
any Governmental Authority.

 

“Liens”
shall mean a lien, charge, security interest, encumbrance, right of first refusal or first offer, preemptive right or other restriction
of any nature, whether voluntarily incurred or arising by operation of Law, including any restriction on the voting of any security,
any restriction on the transfer of any security or other asset, and any restriction or defect on the possession, exercise or transfer
of any other attribute of ownership of any asset.

 

“Material
Adverse Effect” shall mean any change, condition, event, effect, circumstance, development or occurrence (each, an “Effect”)
that, individually or when taken together with all other effects that have occurred prior to the date of determination of the
occurrence of the Material Adverse Effect (a) has, or would reasonably be expected to have, a materially adverse effect on the
business, clinical or pre-clinical programs, intellectual property, condition (financial or other), assets, properties, liabilities
or results of operations of the Company and its Subsidiaries, taken as a whole, (b) would reasonably be expected to prevent, materially
impede or materially delay the Closing or any other transactions contemplated by this Agreement, or (c) would materially and adversely
affect the ability of the Company to perform its obligations under this Agreement; provided, however, that in no event shall any
of the following occurring after the date hereof, alone or in combination, be deemed to constitute, or be taken into account in
determining whether a Material Adverse Effect has occurred: (i) changes in the Company’s industry generally or in conditions
in the PRC or global economy or capital or financial markets generally, including changes in interest or exchange rates, (ii)
any Effect caused by the announcement or pendency of the transactions contemplated by this Agreement, or the identity of such
Purchaser or any of its Affiliates as such Purchaser in connection with the transactions contemplated by this Agreement, (iii)
the performance of this Agreement and the transactions contemplated hereby and thereby, including compliance with the covenants
set forth herein and therein, or any action taken or omitted to be taken by the Company at the written request or with the prior
written consent of such Purchaser, (iv) changes in general legal, regulatory, political, economic or business conditions or changes
to GAAP or interpretations thereof occurring after the date hereof that, in each case, generally affect the biotechnology or biopharmaceutical
industries, (v) acts of war, sabotage or terrorism occurring after the date hereof, or any escalation or worsening of any such
acts of war, sabotage or terrorism, or (vi) earthquakes, hurricanes, floods or other natural disasters occurring after the date
hereof; provided, however, that with respect to clauses (i), (iv), (v) and (vi), such Effects, alone or in combination, may be
deemed to constitute, or be taken into account in determining whether a Material Adverse Effect has occurred, but only to the
extent such Effects disproportionately affect the Company and its Subsidiaries compared to other participants in the biotechnology
or biopharmaceutical industries.

 

    4

     

    

 

“Material
Contract” shall mean any Contract entered into by the Company or any of its Subsidiaries or which binds their respective
properties or assets and that is required under the Exchange Act to be filed as an exhibit to a Company SEC Document pursuant to
Item 601(b)(10) of Regulation S-K.

 

“NASDAQ”
shall mean the NASDAQ Stock Market LLC.

 

“Order”
shall mean any assessment, award, decision, injunction, judgment, order, ruling, verdict or writ entered, issued, made, or rendered
by any court, administrative agency, or other Governmental Authority or by any arbitrator.

 

“Ordinary
Share Equivalents” shall mean any securities of the Company which would entitle the holder thereof to acquire at any
time Ordinary Shares or American Depositary Shares, including, without limitation, any debt, preferred shares, rights, options,
warrants or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the
holder thereof to receive, Ordinary Shares or American Depositary Shares.

 

“Ordinary
Shares” shall mean ordinary shares, par value $0.0001 per share, of the Company.

 

“Person”
shall mean any individual, partnership, limited liability company, firm, corporation, trust, unincorporated organization, government
or any department or agency thereof or other entity, as well as any syndicate or group that would be deemed to be a Person under
Section 13(d)(3) of the Exchange Act.

 

“PRC”
shall mean the People’s Republic of China.

 

“Prospectus”
shall mean the final base prospectus filed for the Registration Statement.

 

“Prospectus
Supplement” shall mean the supplement to the Prospectus complying with Rule 424(b) of the Securities Act that is filed
with the SEC and delivered by the Company to each Purchaser at the Closing.

 

“Registration
Statement” means the “automatic effective shelf registration statement” as defined under Rule 405 of the
Securities Act on Form S-3 filed with the SEC (File No. 333-238181), including all information, documents and exhibits filed with
or incorporated by reference into such registration statement, in respect of the Purchased Shares.

 

“SEC”
shall mean the U.S. Securities and Exchange Commission.

 

“Short Sales”
means all “short sales” as defined in Rule 200 of Regulation SHO under the Exchange Act (but shall not be deemed to
include locating and/or borrowing shares of Common Stock).

 

    5

     

    

 

“Signing Date”
shall have the meaning set forth in the Preamble.

 

“Subscription
Amount” shall mean, with respect to each Purchaser, the aggregate to be paid for the respective Purchased Shares purchased
hereunder as set forth below the Purchaser’s name on the signature page hereto.

 

“Subsidiaries”
shall mean any “significant subsidiary” of the Company as defined in Regulation S-X under the Securities Act.

 

“Tax”
or “Taxes” shall mean any federal, state, local, or non-U.S. income, gross receipts, license, payroll, employment,
excise, severance, stamp, occupation, premium, windfall profits, environmental, customs duties, capital stock, franchise, profits,
withholding, social security (or similar), unemployment, disability, real property, personal property, sales, use, transfer, registration,
value added, alternative or add-on minimum, estimated, or other tax of any kind whatsoever, including any interest, penalty, or
addition thereto, whether disputed or not.

 

“Tax Return”
shall mean any return, declaration, report, claim for refund, or information return or statement relating to Taxes, including any
schedule or attachment thereto, and including any amendment thereof, filed or required to be filed with any Governmental Authority.

 

“Third Party”
shall mean any Person (other than a Governmental Authority) other than the Purchasers, the Company or any Affiliate of the Purchasers
or the Company.

 

“Trading Day”
means a day on which the Trading Market is open for trading.

 

“Trading Market”
means any of the following markets or exchanges on which the Ordinary Shares or the Company is listed or quoted for trading on
the date in question: the Pink OTC Markets, the OTC Bulletin Board, the NASDAQ Capital Market, the NASDAQ Global Market, the NASDAQ
Global Select Market, the NYSE MKT or the New York Stock Exchange.

 

“Transfer”
by any Person shall mean directly or indirectly, to sell, transfer, assign, pledge, encumber, hypothecate or similarly Dispose
of, either voluntarily or involuntarily, or to enter into any contract, option or other arrangement or understanding with respect
to the sale, transfer, assignment, pledge, encumbrance, hypothecation or similar Disposition of, any securities beneficially owned
by such Person or of any interest (including any voting interest) in any securities beneficially owned by such Person. For the
avoidance of doubt, a transfer of control of the direct or indirect beneficial ownership of securities is a Transfer of such securities
for purposes of this Agreement.

 

“Transfer
Agent” shall mean Citibank, N.A. for American Depositary Shares, or Mourant Governance Services (Cayman) Limited for
Ordinary Shares, or any successor transfer agent of the Company, as applicable.

 

2.
                 Closing, Delivery
and Payment.

 

2.1             
Closing. Subject to the terms and conditions hereof, and in reliance on the representations, warranties, covenants
and other agreements hereinafter set forth, at the closing of the transactions contemplated hereby (the “Closing”),
the Company hereby agrees to issue to the Purchasers, and the Purchasers agree to subscribe for, the Purchased Shares, free and
clear of all Liens, for an aggregate purchase price equal to the Purchase Price, and in the case of Baker Bros and Amgen (but
not Hillhouse) as Purchasers, subject to the parameters set out in the Connected Person Placing Authorizations. The Closing shall
take place remotely via the exchange of documents and signatures, as soon as practicable, but in no event later than at 10:00
a.m. (New York City time) on Wednesday, July 15, 2020, subject to the conditions set forth in Article 6 having been satisfied
or waived (other than those conditions that by their nature can only be satisfied at the Closing), or at such other date and time
as the Company and Purchasers shall mutually agree (which date and time are designated as the “Closing Date”).

 

    6

     

    

 

2.2             
Delivery and Payment. At the Closing, subject to the terms and conditions hereof, (a) the Company will deliver to the
Transfer Agent duly executed irrevocable instructions (the “Transfer Instructions”) instructing the Transfer
Agent to deliver to the Purchasers, via book entry to the applicable balance account registered in the name of each Purchaser,
the amount of Purchased Shares set forth on the signature pages hereto, which shall be equal to the quotient resulting from dividing
(i) the Subscription Amount for such Purchaser by (ii) the Purchase Price, rounded down to the nearest Ordinary Share, and (b)
each Purchaser will pay to the Company the Subscription Amount in U.S. dollars by wire transfer of immediately available funds
to the order of the Company.

 

2.3              
Deliveries at Closing.

 

(a)           Deliveries
by the Company. At the Closing, the Company shall deliver or cause to be delivered to each Purchaser the following items:

 

(i)              a
true copy of the Certificate of Incorporation and the Fifth Amended and Restated Memorandum and Articles of Association (the “Articles
of Association”) of the Company;

 

(ii)           
a copy of the Transfer Instructions to the Transfer Agent instructing the Transfer Agent to deliver the Purchased Shares
to each Purchaser on an expedited basis;

 

(iii)           
a legal opinion of Mourant Ozannes, the Company’s Cayman Islands counsel, addressed to the Purchasers, and dated
as of the Closing Date, in form and substance reasonably satisfactory to the Purchasers;

 

(iv)           
an opinion of Goodwin Procter LLP, U.S. counsel for the Company, addressed to the Purchasers, and dated as of the Closing
Date, in form and substance reasonably satisfactory to the Purchasers;

 

(v)             a
certificate addressed to the Purchasers, dated as of the Closing Date, signed by the Company’s principal executive officer
and principal financial officer confirming that the conditions to the Closing set forth in Section 6.1 have been satisfied;

 

(vi)            a
certificate addressed to the Purchasers, dated as of the Closing Date, signed by the Company’s secretary or an assistant
secretary, in form and substance reasonably satisfactory to the Purchasers;

 

    7

     

    

 

(vii)           the
Prospectus and Prospectus Supplement (which may be delivered in accordance with Rule 172 under the Securities Act); and

 

(viii)          all
such other documents, certificates and instruments as such Purchaser may reasonably request in order to give effect to the transactions
contemplated hereby.

 

(b)          
Deliveries by the Purchasers. At the Closing, the Purchasers shall deliver or cause to be delivered to the Company the
following items:

 

(i)             
the Subscription Amount in U.S. dollars by wire transfer of immediately available funds to one or more accounts designated
by the Company.

 

3.                
Representations and Warranties of the Company.
Except as disclosed in the Company SEC Documents (as defined below), the Company hereby represents and warrants to the Purchasers
that as of the date hereof:

 

3.1          
Registration.

 

(a)              
The Registration Statement has been filed with the SEC not earlier than three years prior to the date hereof; such Registration
Statement and any post-effective amendment thereto, became effective on filing and is currently effective; and no stop order suspending
the effectiveness of such registration statement or any part thereof has been issued and no proceeding for that purpose has been
initiated or, to the Company’s knowledge threatened by the SEC, and no notice of objection of the SEC to the use of such
registration statement or any post-effective amendment thereto pursuant to Rule 401(g)(2) under the Securities Act has been received
by the Company. The Company, if required by the rules and regulations of the SEC, shall file the Prospectus Supplement with the
SEC pursuant to Rule 424(b). Any reference herein to the Prospectus or the Prospectus Supplement shall be deemed to refer to and
include the documents incorporated by reference therein pursuant to Item 12 of Form S-3 under the Securities Act, as of the date
of such prospectus. Any reference to any amendment or supplement to the Prospectus or the Prospectus Supplement shall be deemed
to refer to and include any post-effective amendment to the Registration Statement, any prospectus supplement relating to the Purchased
Shares and American Depositary Shares filed with the SEC pursuant to Rule 424(b) under the Securities Act and any documents filed
under the Exchange Act, and incorporated therein, in each case after the date of the Prospectus or such Preliminary Prospectus,
as the case may be; any reference to any amendment to the Registration Statement shall be deemed to refer to and include any annual
report of the Company filed pursuant to Section 13(a) or 15(d) of the Exchange Act after the effective date of the Registration
Statement that is incorporated by reference in the Registration Statement.

 

(b)             
At the time the Registration Statement and any amendments were filed and became automatically effective, at the date
of this Agreement and at the Closing Date, the Registration Statement and any amendments thereto conformed and will conform in
all material respects to the requirements of the Securities Act and did not and will not contain any untrue statement of a material
fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading;
and the Prospectus and any amendments or supplements thereto, at the time the Prospectus or any amendment or supplement thereto
was issued and at the Closing Date, conformed and will conform in all material respects to the requirements of the Securities
Act and did not and will not contain an untrue statement of a material fact or omit to state a material fact necessary in order
to make the statements therein, in the light of the circumstances under which they were made, not misleading.

 

    8

     

    

 

(c)              
The documents incorporated by reference in the Prospectus, when they became effective or were filed with the SEC, as
the case may be, conformed in all material respects to the requirements of the Securities Act or the Exchange Act, as applicable,
and the rules and regulations of the SEC thereunder, and none of such documents contained an untrue statement of a material fact
or omitted to state a material fact required to be stated therein or necessary to make the statements therein not misleading; any
further documents so filed and incorporated by reference in the Prospectus and the Prospectus Supplement or any further amendment
or supplement thereto, when such documents become effective or are filed with the SEC, as the case may be, will conform in all
material respects to the requirements of the Securities Act or the Exchange Act, as applicable, and the rules and regulations of
the SEC thereunder and will not contain an untrue statement of a material fact or omit to state a material fact required to be
stated therein or necessary to make the statements therein not misleading.

 

3.2          
Organization, Good Standing and Qualification.

 

(a)              
The Company is duly incorporated and validly exists as an exempted company incorporated under the laws of the Cayman
Islands and has not been declared bankrupt, granted a suspension of payments or is otherwise subject to insolvency proceedings.
The Company has all requisite corporate power and authority to own and operate its properties and assets, to execute and deliver
this Agreement, to issue and sell the Purchased Shares, and to carry out the provisions of this Agreement and to carry on its business
as presently conducted and as presently proposed to be conducted. Each of the Company’s Subsidiaries (as defined herein)
is an entity duly incorporated or otherwise organized, validly existing and in good standing (to the extent such concept exists
in the relevant jurisdiction) under the Laws of the jurisdiction of its incorporation or organization, as applicable, and has all
requisite power and authority to carry on its business to own and use its properties. Each of the Company and its Subsidiaries
is duly qualified to do business as a foreign entity and is in good standing (to the extent such concept exists in the relevant
jurisdiction) in each jurisdiction in which the conduct of its business or its ownership or leasing of property makes such qualification
necessary, except to the extent any failure to so qualify has not had and would not, individually or in the aggregate, reasonably
be expected to have a Material Adverse Effect.

 

(b)     
          During the twelve (12) months preceding the Signing Date, neither
the Company nor any of its Subsidiaries has taken any action nor have any other steps been taken or Actions commenced or, to
the Company’s knowledge, threatened against any of them, for their winding up or dissolution or for any of them to
enter into any arrangement, scheme or composition for the benefit of creditors, or for the appointment of a receiver,
administrator, liquidator, trustee or similar officer of any of them, or any of their respective properties, revenues or
assets.

 

3.3        
Subsidiaries. The Company has no Subsidiaries except as disclosed in the Company SEC Documents. Except as disclosed
in the Company SEC Documents, the Company owns, directly or indirectly, all of the capital stock or other equity interests of
each Subsidiary, free and clear of any Liens, and all of the issued
and outstanding shares of capital stock of each Subsidiary are validly issued and are fully paid and, if applicable in the relevant
jurisdiction, non-assessable, and free of preemptive and similar rights to subscribe for or purchase securities.

 

    9

     

    

 

3.4          
Capitalization.

 

(a)              
The capitalization of the Company is as set forth in the Company SEC documents, including the number of (i) options
to acquire Ordinary Shares that have been granted and are outstanding, (ii) restricted share awards that have been granted and
are outstanding, (iii) restricted share unit awards that have been granted and are outstanding, and (iv) Ordinary Shares that remained
available for future issuance to board members, senior executives, employees and consultants of the Company and its Subsidiaries
under the Company’s 2011 Option Plan, Second Amended and Restated 2016 Share Option and Incentive Plan, Amended and Restated
2018 Inducement Equity Plan, and Second Amended and Restated 2018 Employee Share Purchase Plan (together with any future equity
compensation or share plans for employees, consultants and directors, collectively, the “Plans”), in each case
as of March 31, 2020.

 

(b)              
Except as disclosed in the Company SEC Documents, and other than the Ordinary Shares reserved for issuance under the
Plans, there are no outstanding options, rights (including conversion or preemptive rights and rights of first refusal), proxy
or shareholder agreements, or agreements of any kind for the purchase or acquisition from the Company or any of its Subsidiaries
of any of its securities, including the Purchased Shares. Except as disclosed in the Company SEC Documents, no Person is entitled
to preemptive rights, rights of first refusal, rights of participation or similar rights with respect to any securities of the
Company or any of its Subsidiaries, including with respect to the issuance of Purchased Shares contemplated hereby. Except as disclosed
in the Company SEC Documents, there are no voting agreements, registration rights agreements or other agreements of any kind among
the Company or any of its Subsidiaries and any other Person relating to the securities of the Company or any of its Subsidiaries,
including the Purchased Shares.

 

(c)              
All of the issued and outstanding Ordinary Shares have been duly authorized and validly issued and are fully paid and
were issued in compliance with all applicable Laws concerning the issuance of securities. The Purchased Shares have been duly and
validly authorized and, when issued and paid for pursuant to this Agreement, will be validly issued, and fully paid. Upon deposit
of the Purchased Shares with the Depositary, the Deposit Shares (i) will have been duly and validly authorized and validly issued,
(ii) will form part of the same class of American Depositary Shares and will have the same profit entitlement and voting rights
as the American Depositary Shares, (iii) will not be subject to pre-emptive rights, and (iv) shall be free and clear of all Liens,
except for restrictions on transfer imposed by applicable securities Law. The Purchased Shares (i) will form part of the same class
of Ordinary Shares and will have the same profit entitlement and voting rights as the Ordinary Shares, (ii) will not be subject
to pre-emptive rights, and (iii) shall be free and clear of all Liens, except for restrictions on transfer imposed by applicable
securities Laws.

 

(d)              
Except as disclosed in the Company SEC Documents, neither the Company nor any of its Subsidiaries owns or holds the
right to acquire any stock, partnership, interest, joint venture interest or other equity ownership interest in any Person.

 

    10

     

    

 

3.5         Authorization;
Binding Obligations. All corporate action on the part of the Company and its supervisory and management boards necessary for
the authorization of this Agreement, the performance of all obligations of the Company hereunder and thereunder at the Closing
and the authorization, sale, issuance and delivery of the Purchased Shares pursuant hereto, and the issuance of the Deposit Shares
upon the deposit of the Purchased Shares with the Depositary, has been taken, including the approval by the board of directors
of the Company to issue the Purchased Shares, to exclude any rights of pre-emption in respect of such issuance, and to approve
payment in U.S. dollars for the Purchased Shares. No other action is required on the part of the Company, its board of directors,
or its shareholders prior to the Closing for the consummation of the transactions contemplated by this Agreement, except for the
filing of a listing application with the HK Stock Exchange. This Agreement has been duly executed and delivered by the Company
and, assuming due authorization, execution and delivery by the Purchasers, constitutes valid and binding obligations of the Company
enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium
or other Laws of general application affecting enforcement of creditors’ rights, (b) as limited by general principles of
equity that restrict the availability of equitable remedies and (c) to the extent that the enforceability of indemnification provisions
may be limited by applicable Laws.

 

3.6          
Company SEC Documents; Financial Statements; NASDAQ.

 

(a)              
Since December 31, 2019, the Company has timely filed with the SEC all of the reports and other documents required to
be filed by it under the Exchange Act and Securities Act and any required amendments to any of the foregoing (the “Company
SEC Documents”). As of their respective filing dates, each of the Company SEC Documents complied in all material respects
with the requirements of the Securities Act and the Exchange Act applicable to such Company SEC Documents, and, when filed, no
Company SEC Documents contained an untrue statement of a material fact or omitted to state a material fact required to be stated
therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading.
None of the Company’s Subsidiaries are subject to the periodic reporting requirements of the Exchange Act. As of the date
hereof, there are no outstanding or unresolved comments in comment letters from the SEC staff with respect to any of the Company
SEC Documents and the Company has not been notified that any of the Company SEC Documents is the subject of ongoing SEC review
or outstanding investigation.

 

(b)               The
financial statements of the Company included in the Company SEC Documents when filed complied as to form in all material respects
with applicable accounting requirements and the published rules and regulations of the SEC with respect thereto, have been prepared
in accordance with GAAP applied on a consistent basis during the periods involved (except as may be indicated in the notes thereto)
and fairly present in all material respects the financial position of the Company as of the dates thereof and the results of its
operations and cash flows for the periods then ended. Except (i) as set forth in the Company SEC Documents or (ii) for liabilities
incurred in the ordinary course of business consistent with past practice subsequent to the date of the most recent balance sheet
contained in the Company SEC Documents, the Company has no liabilities, whether absolute or accrued, contingent or otherwise,
other than those that would not, individually or in the aggregate, be material to the Company and its Subsidiaries taken as a
whole. Neither the Company nor any of its Subsidiaries has or is subject to any “Off-Balance Sheet Arrangement” (as
defined in Item 303(a)(4)(ii) of Regulation S-K promulgated under the Securities Act).

 

    11

     

    

 

(c)               The
American Depositary Shares are listed on the NASDAQ Global Select Market, and the Company has not received any notification that,
and has no knowledge that, NASDAQ is contemplating terminating such listing.

 

3.7         
Compliance with Other Instruments. Neither the Company nor any of its Subsidiaries is in violation or default of any
term of its Articles of Association, charter, certificate of incorporation, bylaws, limited partnership agreement, or other organizational
or constitutive documents. No Material Contract has been materially breached or cancelled, and there has been no event which, upon
giving of notice or lapse of time or both, would constitute such a material breach or default, by the Company (and to the knowledge
of the Company, the other party thereto). The Company (and to the knowledge of the Company, the other party thereto) has performed
all material obligations under each Material Contract required to be performed by it. Each Material Contract is legal, valid, binding,
enforceable against the Company and, to the knowledge of the Company, against each other party thereto, and is in full force and
effect, and will continue to be in full force and effect and legally and validly binding and enforceable against each other party
thereto following the consummation of the transactions contemplated hereby. The execution, delivery, and performance of and compliance
with the Agreement, and the issuance and sale of the Purchased Shares pursuant hereto, will not, with or without the passage of
time or giving of notice, (i) conflict with or result in a violation of the Articles of Association, charter, certificate of incorporation,
bylaws, limited partnership agreement, or other organizational or constitutive documents of the Company or any of its Subsidiaries,
in each case as in effect on the Closing Date, (ii) result in any violation in any material respect of any Law or Order to which
the Company, any of its Subsidiaries or any of their respective assets is subject, including but not limited to the HK Listing
Rules and the Securities and Futures Ordinance (Cap. 571 of the Laws of Hong Kong), (iii) (A) conflict with or result in a breach,
violation of, or constitute a default under, (B) give any Third Party the right to modify, terminate or accelerate, or cause any
modification, termination or acceleration of, any obligation under, or (C) require Consent or notice under, any Material Contract
to which the Company or any of its Subsidiaries is a party, or (iv) result in the creation of any Lien upon any of the Company’s
or any Subsidiary’s assets or capital stock, except in the case of any of clauses (iii) and (iv) above, as would not, individually
or in the aggregate, reasonably be expected to have a Material Adverse Effect. Neither the execution, delivery or performance of
this Agreement by the Company, nor the consummation by it of the obligations and transactions contemplated hereby (including the
issuance of the Purchased Shares) requires any Consent or other filing with or notice to any Governmental Authority, other than
(i) filings required under applicable U.S. federal and state securities Laws, (ii) the notification of the issuance and sale of
the Purchased Shares to NASDAQ, and (iii) the formal application for, and the granting of, the listing of and permission to deal
in all of the Purchased Shares by the HK Stock Exchange.

 

3.8          
Litigation. Except as disclosed in the Company SEC Documents, there is no material: (i) Action pending or, to the Company’s
knowledge, threatened, against the Company or any of its Subsidiaries which, if determined adversely to the Company or any of its
Subsidiaries would, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect or (ii) Order in
effect against the Company or any of its Subsidiaries.

 

3.9          
Compliance with Laws; Permits. The Company and each of its Subsidiaries is, and since January 1, 2016 has been, in
material compliance with all applicable Laws and Orders (including all Health Care Laws). The Company and each of its Subsidiaries
has all franchises, permits, licenses, approvals, registrations, filings, qualifications, variances, certificates, certifications,
Consents and any similar authority (collectively, “Permits”) necessary for the conduct of its business as now
being conducted by it and as described in the Company SEC Documents, except those Permits for which the lack of such Permit would
not, individually or in the aggregate, reasonably be expected to have a Material Adverse Effect, and is in compliance in all material
respects with the terms of all such Permits.

 

    12

     

    

 

3.10         
Investment Company. The Company is not, and after giving effect to the transactions contemplated by this Agreement will
not be, an “investment company” or a company “controlled” by an “investment company,” within
the meaning of the Investment Company Act of 1940, as amended.

 

3.11         
Absence of Changes. Since December 31, 2019, (a) the Company and each of its Subsidiaries has conducted its business
operations in the ordinary course of business consistent with past practice, (b) none of the Company and its Subsidiaries have
(i) entered into or assumed or otherwise agreed to be bound by any Contract or agreement, (ii) incurred, assumed or acquired or
otherwise agreed to become subject to any liability (including, without limitation, contingent liability) or other obligation or
(iii) acquired or disposed of or agreed to acquire or dispose of any business or asset, that would, in any of clauses (i) through
(iii) above, be material to the Company and its Subsidiaries and that are not otherwise described in the Company SEC Documents,
(c) none of the Company and its Subsidiaries have sustained any material loss or interference with its business from fire, explosion,
flood, earthquake or other calamity, whether or not covered by insurance, or from any labor dispute or any Order of any Governmental
Authority, except as otherwise disclosed in the Company SEC Documents and (d) there has not occurred any event, change, development,
circumstance or condition that, individually or in the aggregate, has had or would reasonably be expected to have a Material Adverse
Effect.

 

3.12         
Deposit Agreement. The Deposit Agreement was duly authorized, executed and delivered by the Company and constitutes
a valid and legally binding agreement of the Company, enforceable in accordance with its terms, subject, as to enforceability,
to bankruptcy, insolvency, reorganization and similar laws of general applicability relating to or affecting creditors’ rights
and to general equity principles. The Deposit Agreement, the American Depositary Shares and the American Depositary Receipts conform
in all material respects to the descriptions thereof contained in the Company SEC Documents and, upon the deposit of the Purchased
Shares in accordance with the provisions of the Deposit Agreement, (i) the Depositary will issue the Deposit Shares, and (ii) when
issued, the Deposit Shares will be entitled to the rights specified therein and in the Deposit Agreement.

 

3.13         
Internal Controls. 

 

(a)              
The Company maintains a system of internal accounting controls sufficient to provide reasonable assurance that: (i)
transactions are executed in accordance with management’s general or specific authorizations; (ii) transactions are recorded
as necessary to permit preparation of financial statements in conformity with GAAP; (iii) access to assets is permitted only in
accordance with management’s general or specific authorization; (iv) the recorded accountability for assets is compared
with existing assets at reasonable intervals and appropriate actions are taken with respect to any differences; and (v) the Company
has made and kept books, records and accounts which, in reasonable detail, accurately and fairly reflect the transactions and
dispositions of assets of such entity.

 

    13

     

    

 

(b)              
The Company has established and maintains and evaluates a system of internal controls over financial reporting (as such
term is defined in Rule 13a-15(f) of the Exchange Act) that complies with the requirements of the Exchange Act and has been designed
by the Company’s principal executive officer and principal financial officer, or under their supervision, to provide reasonable
assurance regarding the reliability of financial reporting and the preparation of financial statements for external purposes in
accordance with GAAP. Such internal controls over financial reporting has been designed by the Company’s chief executive
officer and chief financial officer, or under their supervision, to provide reasonable assurance regarding the reliability of financial
reporting and the preparation of financial statements for external purposes in accordance with GAAP. All material weaknesses, if
any, in such internal controls have been identified to the Company’s accountants and the audit committee of the Company’s
board of directors. Since the date of the latest audited financial statements included or incorporated by reference in the Company
SEC Documents, there has been no change in the Company’s internal control over financial reporting or in other factors that
could significantly affect such internal controls, including any corrective actions with regard to significant deficiencies and
material weaknesses. Except as described in the Company SEC Documents, the Company’s independent accountants have not notified
the Company of any “reportable conditions” (as that term is defined under standards established by the American Institute
of Certified Public Accountants) in the Company’s internal accounting controls, or other weaknesses or deficiencies in the
design or operation of the Company’s internal accounting controls, that has materially affected, or would reasonably be expected
to materially affect, the Company’s internal control over financial reporting, or could adversely affect the Company’s
ability to record, process, summarize and report financial data consistent with the assertions of the Company’s management
in the financial statements. The Company has taken all necessary actions to ensure that the Company, its Subsidiaries and their
respective officers and directors, in their capacities as such, are in compliance in all material respects with the applicable
provisions of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”) and the rules and regulations promulgated
thereunder. The Company has given due consideration to the findings of any reports by its consultants with respect to its system
of internal controls.

 

(c)              
The Company has established, maintained and evaluated disclosure and corporate governance controls and procedures that
comply with the requirements of the Exchange Act to ensure that (i) material information relating to the Company is made known
in a timely manner to the Company’s board of directors, principal executive officer and principal financial officer by others
within those entities, and (ii) the Company and its board of directors comply in a timely manner with the requirements of the
HK Listing Rules, the Hong Kong Codes on Takeovers and Mergers and Share Buy-backs, the Securities and Futures Ordinance, the
Companies Ordinance, the Companies (Winding Up and Miscellaneous Provisions) Ordinance (Chapter 32 of the Laws of Hong Kong) and
any other applicable Law relating to disclosure of information and reporting obligations, including, without limitation, the requirements
of the HK Listing Rules on disclosure of inside information and notifiable, connected and other transactions required to be disclosed.
Such disclosure and corporate governance controls and procedures are effective to properly perform the functions for which they
were established and documented, and the implementation of such disclosure and corporate governance controls and procedures policies
are monitored by the responsible persons. As used herein, the term “disclosure and corporate governance controls and procedures”
means controls and other procedures that are designed to ensure that information required to be disclosed by the Company (including,
without limitation, information in reports that it files or submits under any applicable Law, inside information and information
on notifiable, connected and other transactions required to be disclosed) is recorded, processed, summarized and reported in a
timely manner (and in any event within the time period required by applicable Law).

 

    14

     

    

 

3.14       
Intellectual Property. Except as described in the Company SEC Documents, in each case, (a) the Company or its applicable
controlled Subsidiary owns, possesses, licenses or has other rights to use all patents, copyrights, trademarks, service marks,
trade names, Internet domain names, technology, and/or know-how (including trade secrets and other unpatented and/or unpatentable
proprietary rights), including registrations and/or applications for registration with respect to any of the foregoing (collectively,
 “Intellectual Property”) that are necessary or otherwise material to their businesses as they are currently
conducted and described in the Company SEC Documents; (b) all copyrights and patents owned or licensed by the Company or any of
its Subsidiaries (including all copyrights and patents owned or licensed by any of the Company’s Subsidiaries) are (i) to
the Company’s knowledge, valid and enforceable and (ii) not subject to any ongoing or, to the Company’s knowledge,
threatened interference, reexamination, judicial or administrative proceeding pertaining to validity, enforceability or scope;
(c) neither the Company nor any of its Subsidiaries has received any written notice alleging, nor, to the Company’s knowledge,
is there, any infringement, violation or conflict with (and Company does not know of any basis for alleging infringement, violation
or conflict with) the Intellectual Property rights of any Third Party by the Company or any of its Subsidiaries, or their products;
(d) there are no pending or, to the Company’s knowledge, threatened actions, suits, proceedings or claims that allege the
Company or any of its Subsidiaries is infringing or has infringed any Intellectual Property right of any Third Party; (e) the discoveries,
inventions, products or processes of the Company or any of its Subsidiaries, to the Company’s knowledge, do not violate or
conflict with any Intellectual Property right of any Third Party including any discovery, invention, product or process that is
the subject of a patent application filed by any Third Party; and (f) neither the Company nor any of its Subsidiaries is in breach
of any license or other agreement (to which it is a party) related to the Intellectual Property rights of the Company, any Subsidiary
of the Company or any Third Party.

 

3.15       
Taxes.

 

(a)              
The Company and each of its Subsidiaries has (i) filed all material Tax Returns that are required to be filed or has
requested extensions thereof and (ii) except as would not give rise to a Material Adverse Effect, has paid all Taxes required to
be paid by it and any other assessment, fine or penalty levied against it, to the extent that any of the foregoing is due and payable,
except for any such assessment, fine or penalty that is currently being contested in good faith; the provisions included in the
audited consolidated financial statements as set out or incorporated by reference in the Company SEC Documents include appropriate
provisions required under GAAP for all taxation in respect of accounting periods ended on or before the accounting reference date
to which such audited accounts relate for which the Company was then or might reasonably be expected thereafter to become or have
become liable; and neither the Company nor any of its subsidiaries has received notice of any Tax deficiency with respect to the
Company or any of its Subsidiaries.

 

    15

     

    

 

(b)             
 To the Company’s knowledge, the Company is not and was not a “controlled foreign corporation” within
the meaning of Section 957 of the Code (a “CFC”) at any point during the Company’s taxable year through
the date of this Agreement. The Company does not expect to become a CFC as a result of the transactions contemplated by this Agreement.

 

(c)              
To the Company’s knowledge, the Company and each of its controlled subsidiaries is not as of the date of this
Agreement a “passive foreign investment company” within the meaning of Section 1297 of the Code (a “PFIC”)
and the Company does not expect that either Purchaser will be considered a PFIC shareholder as a result of the transactions contemplated
by this Agreement.

 

3.16       
Anti-Corruption, Anti-Money Laundering and Anti-Bribery Laws.

 

(a)              To
the Company’s knowledge, none of the Company and its Subsidiaries, their respective directors, officers, employees and,
to the Company’s knowledge, agents or other authorized persons acting on behalf of the Company are aware of or have taken
any action, directly or indirectly, that could result in a violation or a sanction for violation by such persons of the Foreign
Corrupt Practices Act of 1977, the U.K. Bribery Act 2010, the PRC Law on Anti-Unfair Competition promulgated on September 2, 1993,
the Interim Rules on Prevention of Commercial Bribery promulgated on November 15, 1996, or any PRC Law in relation thereto, each
as may be amended, or similar law of any other relevant jurisdiction, or the rules or regulations thereunder; and the Company
has instituted and maintain policies and procedures to ensure compliance therewith.

 

(b)              To
Company’s knowledge, none of the Company and its Subsidiaries, their respective directors, officers, employees and, to the
Company’s knowledge, agents or other authorized persons acting on behalf of the Company have (i) used any corporate funds
for any illegal contributions, gifts, entertainment or other unlawful expenses relating to political activity, (ii) used any corporate
funds for any direct or indirect unlawful payments to any foreign or domestic government officials or employees, (iii) established
or maintained any fund of corporate monies or other properties not recorded on the books and records of the Company and its Subsidiaries,
(iv) made any bribe, unlawful rebate, payoff, influence payment, kickback or other unlawful payment of any nature, or (v) violated
or operated in noncompliance with any applicable money laundering law, anti-terrorism law or regulation, anti-boycott regulations,
export restrictions or embargo regulations, including those referenced in Section 3.16(a) above.

 

(c)              The
operations of the Company and its Subsidiaries are and have been conducted at all times in compliance in all material respects
with the requirements of applicable anti-money laundering laws, including but not limited to, the Currency and Foreign Transactions
Reporting Act of 1970, as amended, the Bank Secrecy Act of 1970, as amended by the USA PATRIOT ACT of 2001, the Organized and
Serious Crimes Ordinance (Chapter 455 of the Laws of Hong Kong) and the Anti-Money Laundering and Counter-Terrorist Financing
(Financial Institutions) Ordinance (Chapter 615 of the Laws of Hong Kong), and the rules and regulations promulgated thereunder,
and the anti-money laundering laws of the various jurisdictions in which the Company and its Subsidiaries conduct business (collectively,
the “Anti-Money Laundering Laws”); and no Action, suit or proceeding by or before any court or governmental
agency, authority or body or any arbitrator or non-governmental authority involving the Company or any of its Subsidiaries with
respect to the Anti-Money Laundering Laws is pending or, to the Company’s knowledge, threatened.

 

    16

     

    

 

 

3.17         
Clinical and Product Regulatory.

 

(a)              
All preclinical studies and clinical trials conducted by or on behalf of the Company that are material to the Company
and its Subsidiaries, taken as a whole, have been adequately described in the Company SEC Documents in all material respects.
The preclinical studies and clinical trials conducted by or on behalf of the Company were and, if still ongoing, are being conducted
in material compliance with all Laws and regulations applicable thereto in the jurisdictions in which they are being conducted
and with all Laws and regulations applicable to preclinical studies and clinical trials from which data will be submitted to support
marketing approval. The descriptions in the Company SEC Documents of the results of such studies and trials are accurate and complete
in all material respects and fairly present the data derived from such studies, and the Company has no knowledge of any large
well-controlled clinical trial the aggregate results of which call into question the results of any clinical trial conducted by
or on behalf of the Company that are described in the Company SEC Documents or the results of which are referred to in the Company
SEC Documents. Except as disclosed in the Company SEC Documents or as would not reasonably be expected to have a Material Adverse
Effect, the Company has not received any notices or statements from the U.S. Food and Drug Administration (“FDA”),
the European Medicines Agency (“EMA”), the National Medical Products Administration (“NMPA”)
or any comparable regulatory agency (each a “Product Regulatory Authority”) imposing, requiring, requesting
or suggesting a clinical hold, termination, suspension or material modification for or of any preclinical studies or clinical
trials that are described in the Company SEC Documents or the results of which are referred to in the Company SEC Documents. Except
as disclosed in the Company SEC Documents or as would not reasonably be expected to have a Material Adverse Effect, the Company
has not received any notices or statements from any Product Regulatory Authority, and otherwise has no knowledge of any license,
approval, permit or authorization to conduct any clinical trial of any potential product of the Company has been, will be or may
be suspended, revoked, materially modified or limited.

 

(b)               Since
January 1, 2017, except as disclosed in the Company SEC Documents or as would not reasonably be expected to have a Material Adverse
Effect, the Company and each of its Subsidiaries: (i) are and have been in compliance with all statutes, rules, or regulations
applicable to the ownership, testing, development, manufacture, packaging, processing, use, distribution, labeling, storage, import,
export or disposal of any product manufactured or distributed by the Company (“Applicable Product Laws”); (ii)
have not received any FDA Form 483, notice of adverse finding, warning letter, untitled letter or other correspondence or notice
from any Product Regulatory Authority alleging or asserting non-compliance with any Applicable Product Laws or any licenses, certificates,
approvals, clearances, authorizations, permits and supplements or amendments thereto required by any such Applicable Product Laws
(“Product Authorizations”); (iii) possess all Product Authorizations and such Product Authorizations are valid
and in full force and effect and are not in violation of any term of any such Product Authorizations; (iv) have not received notice
of any claim, action, suit, proceeding, hearing, enforcement, investigation, arbitration or other action from any Product Regulatory
Authority alleging that any product operation or activity is in violation of any Applicable Product Laws or Product Authorizations
and, to the Company’s knowledge, no such proceedings are threatened or contemplated by any such Product Regulatory Authority;
(v) have not received notice that any Product Regulatory Authority has taken, is taking or will take action to limit, suspend,
modify or revoke any Product Authorizations, and to the Company’s knowledge, no such Product Regulatory Authority has threatened
such action; and (vi) have filed, obtained, maintained or submitted all reports, documents, forms, notices, applications, records,
claims, submissions and supplements or amendments as required by any Applicable Product Laws or Product Authorizations and that
all such reports, documents, forms, notices, applications, records, claims, submissions and supplements or amendments were complete
and correct on the date filed (or were corrected or supplemented by a subsequent submission).

 

    17

     

    

 

4.                 Representations
and Warranties of the Purchasers. Each Purchaser hereby, for itself and no other Purchaser, represents and warrants
as of the date hereof to the Company as follows:

 

4.1             
Organization; Good Standing. Such Purchaser is either an individual or an entity duly incorporated or formed, validly
existing and in good standing (to the extent such concept exists in the relevant jurisdiction) under the laws of its jurisdiction
of incorporation or formation with full right, corporate, partnership, limited liability company or similar power and authority
to enter into and to consummate the transactions contemplated under this Agreement and otherwise to carry out its obligations
hereunder. Such Purchaser has or will have all requisite power and authority to enter into this Agreement, to subscribe for the
Purchased Shares and to perform its obligations under and to carry out the transactions contemplated by this Agreement, and no
further approval or authorization by any of its members or other equity owners, as the case may be, is required.

 

4.2             
Requisite Power and Authority. Such Purchaser has all necessary power and authority to execute and deliver this Agreement
and all action on the Purchaser’s part required for the lawful execution and delivery of this Agreement has been taken.
This Agreement has been duly and validly executed and delivered by the Purchaser and, assuming due authorization, execution and
delivery by the Company, constitutes valid and binding obligations of such Purchaser, enforceable in accordance with their terms,
except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium or other Laws of general application
affecting enforcement of creditors’ rights, (b) as limited by general principles of equity that restrict the availability
of equitable remedies, and (c) to the extent that the enforceability of indemnification provisions may be limited by applicable
Laws.

 

4.3             
No Conflicts. The execution, delivery and performance of this Agreement and compliance with the provisions thereof
by such Purchaser will not, with or without the passage of time or giving of notice: (i) conflict with or result in a violation
of the certificate of incorporation, bylaws, or other organizational or constitutive documents of such Purchaser as in effect
on the Closing Date, (ii) result in any violation of any Law or Order to which such Purchaser or any of its assets is subject,
(iii) (A) conflict with or result in a breach, violation of, or constitute a default under, or (B) give any Third Party the right
to modify, terminate or accelerate, or cause any modification, termination or acceleration of, any obligation under any Contract
to which such Purchaser is a party, or (iv) result in the creation of any Lien upon any of the Purchasers’ assets or equity
interests, except in the case of any of clauses (ii), (iii) and (iv) above, as would not reasonably be expected to materially
impair of the ability of such Purchaser to perform its obligations under this Agreement and the transactions contemplated thereby
in any material respect.

 

    18

     

    

 

4.4              No
Governmental Authority or Third Party Consents. No Consent is required to be obtained or filed by such Purchaser in connection
with the authorization, execution and delivery of this Agreement or with the subscription for the Purchased Shares.

 

4.5             
Purchaser Status. At the time such Purchaser was offered the Purchased Shares, it was, and as of the date hereof it
is, either: (i) an “accredited investor” as defined in Rule 501(a)(1), (a)(2), (a)(3), (a)(7) or (a)(8) under the
Securities Act or (ii) a “qualified institutional buyer” as defined in Rule 144A(a) under the Securities Act.

 

4.6              Experience
of Such Purchaser. Such Purchaser, either alone or together with its representatives, has such knowledge, sophistication and
experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment
in the Purchased Shares, and has so evaluated the merits and risks of such investment. Such Purchaser is able to bear the economic
risk of an investment in the Purchased Shares and, at the present time, is able to afford a complete loss of such investment.

 

4.7             
Certain Transactions and Confidentiality. Other than consummating the transactions contemplated hereunder, such Purchaser
has not, nor has any Person acting on behalf of or pursuant to any understanding with such Purchaser, directly or indirectly executed
any purchases or sales, including Short Sales, of the securities of the Company during the period commencing as of the time that
such Purchaser first received a term sheet (written or oral) from the Company or any other Person representing the Company setting
forth the material terms of the transactions contemplated hereunder and ending immediately prior to the execution hereof. Notwithstanding
the foregoing, in the case of a Purchaser that is a multi-managed investment vehicle whereby separate portfolio managers manage
separate portions of such Purchaser’s assets and the portfolio managers have no direct knowledge of the investment decisions
made by the portfolio managers managing other portions of such Purchaser’s assets, the representation set forth above shall
only apply with respect to the portion of assets managed by the portfolio manager that made the investment decision to purchase
the Purchased Shares covered by this Agreement. Other than to other Persons party to this Agreement or to such Purchaser’s
representatives, including, without limitation, its officers, directors, partners, legal and other advisors, employees, agents
and Affiliates, such Purchaser has maintained the confidentiality of all disclosures made to it in connection with this transaction
(including the existence and terms of this transaction). Notwithstanding the foregoing, for the avoidance of doubt, nothing contained
herein shall constitute a representation or warranty, or preclude any actions, with respect to locating or borrowing shares in
order to effect Short Sales or similar transactions in the future.

 

The Company acknowledges
and agrees that the representations contained in this Section 4 shall not modify, amend or affect such Purchaser’s right
to rely on the Company’s representations and warranties contained in this Agreement or any other document or instrument
executed and/or delivered in connection with this Agreement or the consummation of the transactions contemplated hereby. Notwithstanding
the foregoing, for the avoidance of doubt, nothing contained herein shall constitute a representation or warranty, or preclude
any actions, with respect to locating or borrowing shares in order to effect Short Sales or similar transactions in the future.

 

    19

     

    

 

5.                 
Covenants and Agreements.

 

5.1             
Securities Laws Disclosure; Publicity. The Company shall provide Purchasers, for their review, copies of the Prospectus
Supplement and any Form 8-K, press release or other communication to be issued by the Company relating to the Purchased Shares.
The Company shall issue a press release and a Hong Kong regulatory announcement disclosing the material terms of the transactions
contemplated hereby, and file a Current Report on Form 8-K, including a form of this Agreement as an exhibit thereto no later
than 8:30 a.m. (New York City time) on the first Business Day immediately following the Signing Date. From and after the issuance
of such press release, Current Report on Form 8-K and Hong Kong regulatory announcement, the Company represents to the Purchasers
that it shall have publicly disclosed all material, non-public information delivered to any of the Purchasers by the Company or
any of its Subsidiaries, or any of their respective officers, directors, employees or agents in connection with the transactions
contemplated by this Agreement. In addition, effective upon the issuance of such press release and Hong Kong regulatory announcement,
the Company acknowledges and agrees that any and all confidentiality or similar obligations under any agreement, whether written
or oral, between the Company, any of its Subsidiaries or any of their respective officers, directors, agents, employees or Affiliates
on the one hand, and any of the Purchasers or any of their Affiliates on the other hand, with respect to the transactions contemplated
by this Agreement shall terminate. The Company shall not publicly disclose the name of any Purchaser, or include the name of any
Purchaser in any filing with the SEC or any regulatory agency or Trading Market, without the prior written consent of such Purchaser,
except as required by securities laws or the rules of the SEC or the HK Listing Rules.

 

5.2             
Furnishing of Information. Until the time that no Purchaser owns Ordinary Shares, the Company covenants to timely file
(or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the
Company after the date hereof pursuant to the Exchange Act even if the Company is not then subject to the reporting requirements
of the Exchange Act.

 

5.3             
Non-Public Information. Except with respect to the material terms and conditions of the transactions contemplated by
this Agreement, which shall be disclosed pursuant to Section 5.1, the Company covenants and agrees that neither it, nor any other
Person acting on its behalf will provide any Purchaser or its agents or counsel with any information that constitutes, or the
Company reasonably believes constitutes, material non-public information, unless prior thereto such Purchaser shall have consented
in writing to the receipt of such information and agreed with the Company to keep such information confidential. The Company understands
and confirms that each Purchaser shall be relying on the foregoing covenant in effecting transactions in securities of the Company.
To the extent that the Company delivers any material, non-public information to a Purchaser without such Purchaser’s consent,
the Company hereby covenants and agrees that such Purchaser shall not have any duty of confidentiality to the Company, any of
its Subsidiaries, or any of their respective officers, directors, agents, employees or Affiliates, or a duty to the Company, any
of its Subsidiaries or any of their respective officers, directors, agents, employees or Affiliates not to trade on the basis
of, such material, non-public information, provided that the Purchaser shall remain subject to applicable law. To the extent that
any notice provided pursuant to this Agreement constitutes, or contains, material, non-public information regarding the Company
or any Subsidiaries, the Company shall simultaneously file such notice with the SEC pursuant to a Current Report on Form 8-K.
The Company understands and confirms that each Purchaser shall be relying on the foregoing covenant in effecting transactions
in securities of the Company.

 

    20

     

    

 

5.4             
Further Assurances. Subject to the terms and conditions of this Agreement, each of the Company and the Purchasers agree
to use its commercially reasonable efforts to take, or cause to be taken, all actions, and to do, or cause to be done, and assist
the other party hereto in doing, all things reasonably necessary, proper or advisable to obtain prompt satisfaction of the conditions
precedent to the consummation of the transactions contemplated at the Closing, and to comply with any regulatory requirements
under the HK Listing Rules, including:  (a) obtaining all necessary Consents and the making of all filings and the taking
of all steps as may be necessary, including convening any prerequisite meetings of bodies of the Company, to obtain a required
Consent or avoid an Action by any Governmental Authority, (b) the defending of any Actions challenging this Agreement or the consummation
of the transactions contemplated hereby or thereby, including seeking to have any stay or temporary restraining order entered
by any court or other Governmental Authority vacated or reversed, (c) the execution and delivery of any additional instruments
necessary to consummate the transactions contemplated by, and to fully carry out the purposes of, this Agreement, and (d) the
Purchasers providing any information reasonably requested by the Company to allow it to publish public announcements regarding
this Agreement and the transactions contemplated hereunder and thereunder pursuant to the HK Listing Rules and to respond to any
queries raised by the HK Stock Exchange. 

 

5.5             
Integration.  The Company shall not sell, offer for sale or solicit offers to buy or otherwise negotiate in respect
of any security (as defined in the Securities Act) that would be integrated with the offer or sale of the Purchased Shares to
be issued to the Purchasers hereunder for purposes of the rules and regulations of any of the following markets or exchanges on
which the Ordinary Shares of the Company is listed or quoted for trading on the date in question: the Pink OTC Markets, the OTC
Bulletin Board, the NASDAQ Capital Market, the NASDAQ Global Market, the NASDAQ Global Select Market, the NYSE MKT or the New
York Stock Exchange.

 

5.6             
Notification.  After the date hereof and prior
to the Closing Date, the Company shall as promptly as practicable deliver to the Purchasers a written notice of any event or development
that would, or could reasonably be expected to, result in any condition to the Closing set forth in Section 6, not to be satisfied.

 

5.7             
Equal Treatment of Purchasers.  No consideration (including any modification of this Agreement) shall be offered
or paid to any Person to amend or consent to a waiver or modification of any provision of this Agreement unless the same consideration
is also offered to all of the parties to this Agreement.  For clarification purposes, this provision constitutes a separate
right granted to each Purchaser by the Company and negotiated separately by each Purchaser, and is intended for the Company to
treat the Purchasers as a class and shall not in any way be construed as the Purchasers acting in concert or as a group with respect
to the purchase, disposition or voting of Shares or otherwise.

 

    21

     

    

 

5.8             
 Deposit of Purchased Shares and Issuance of American Depositary Receipts. Upon the written request of such Purchaser
to the Company, the Company will deposit or cause to be deposited such number of Purchased Shares with the Depositary Agent as
is requested by such Purchaser, and issue or cause to be issued to such Purchaser the American Depositary Receipts representing
the corresponding American Depositary Shares, with any and all costs associated with such deposit and issuance paid for by such
Purchaser. The Company shall (a) use its reasonable best efforts to (i) register or qualify such American Depositary Shares under
the securities or blue sky Laws of such jurisdictions in the United States as such Purchaser reasonably requests and do any and
all other acts and things which may be reasonably necessary or advisable to enable such Purchaser to consummate the disposition
in such jurisdictions of the American Depositary Shares owned by such Purchaser and (ii) cause all such American Depositary Shares
to be eligible and remain eligible for registration of the American Depositary Shares pursuant to Form F-6, and (b) cooperate
with such Purchaser and the Depositary Agent to facilitate the timely delivery of American Depositary Shares (in book entry or
certificated form), which American Depositary Shares shall be free of all restrictive legends unless the Company reasonably determines
on advice from legal counsel that such legends are required by applicable law (it being understood that the American Depositary
Shares may be restricted American Depositary Shares subject to restrictions imposed by the Depositary Agent for so long as such
Purchaser is an Affiliate).Economic Substance. For so long as such Purchaser holds Shares or Deposit Shares, the Company
shall, and shall cause its controlled subsidiaries to, use reasonable best efforts to comply with the International Tax Co-operation
(Economic Substance) Law (2020 Revision), of the Cayman Islands so that it does not become a defunct company and is not struck
off.

 

5.9             
Transfer Agent. The Company shall maintain a transfer agent and, if necessary under the jurisdiction of incorporation
of the Company, a registrar for the Ordinary Shares.

 

 

6.                 
Conditions to Closing.

 

6.1             
Conditions to the Purchasers’ Obligations at the Closing. The respective obligations of the Purchasers to purchase
the Purchased Shares at the Closing is subject to the satisfaction, at or prior to the Closing Date, of the following conditions
(unless waived in writing by such Purchaser):

 

(a)              
Representations and Warranties. The representations and warranties made by the Company in Section 3 hereof shall be
true and correct in all material respects as of the Signing Date and the Closing Date as if made on such date, except to the extent
any such representation and warranty is (i) already qualified by materiality, in which case it shall be true and correct as of
such dates or (ii) specifically made as of a particular date, in which case it shall be true and correct as of such date.

 

(b)             
Performance of Obligations. The Company shall have performed and complied in all material respects with all agreements
and conditions herein required to be performed or complied with by the Company on or before the Closing Date.

 

    22

     

    

 

(c)              
 Legal Investment. The sale and issuance of the Purchased Shares shall be legally permitted by all Laws to which such
Purchaser and the Company are subject.

 

(d)               No
Orders. No Order shall be in effect preventing the consummation of the transactions contemplated by this Agreement.

 

(e)              
Closing Deliverables. The Company shall deliver or cause to be delivered to the Purchasers all items listed in Section
2.3(a) at least one Business Day prior to the Closing.

 

(f)               Consents,
Permits, and Waivers. All Consents necessary or appropriate for consummation of the transactions contemplated by this Agreement
shall have been obtained, including the approval of the board of directors of the Company.

 

(g)              
Material Adverse Effect. No Material Adverse Effect shall have occurred.

 

(h)              The
Company’s NASDAQ Listing. The Company’s American Depositary Shares shall continue to be listed on the NASDAQ Global
Select Market.

 

(i)                Effectiveness.
The Registration Statement and any registration statement required to be filed, prior to the sale of the Purchased Shares, under
the Securities Act pursuant to Rule 462(b) shall have been filed and shall have become effective under the Securities Act, and
the Prospectus Supplement shall have been filed with the SEC pursuant to Rule 424(b) under the Securities Act.

 

 

(j)               HK
Stock Exchange. The Company shall have taken all necessary actions to cause the Purchased Shares to be listed and admitted
for trading on the HK Stock Exchange at Closing.

 

6.2              
Conditions to Company’s Obligations at the Closing. The Company’s obligation to issue and sell the Purchased
Shares at the Closing is subject to the satisfaction, on or prior to the Closing Date, of the following conditions (unless waived
in writing by the Company):

 

(a)              
Representations and Warranties. The representations and warranties in Section 4 made by the Purchasers shall be
true and correct in all material respects as of the Signing Date and the Closing Date as if made on such date, except to the extent
any such representation and warranty is (i) already qualified by materiality, in which case it shall be true and correct as of
such dates or (ii) specifically made as of a particular date, in which case it shall be true and correct as of such date.

 

(b)             
Performance of Obligations. Such Purchaser shall have performed and complied in all material respects with all agreements
and conditions herein required to be performed or complied with by such Purchaser on or before the Closing Date.

 

    23

     

    

 

(c)              
 Legal Investment. The sale and issuance of the Purchased Shares shall be legally permitted by all Laws to which the
Purchasers and the Company are subject.

 

(d)               No
Orders. No Order shall be in effect preventing the consummation of the transactions contemplated by this Agreement.

 

(e)              
Closing Deliverables. Such Purchaser shall deliver or cause to be delivered to the Company all items listed in Section
2.3(b).

 

7.                 
Miscellaneous.

 

7.1             
Termination. This Agreement may be terminated at any time prior to the Closing by any Purchaser, as to such Purchaser’s
obligations hereunder only and without any effect whatsoever on the obligations between the Company and the other Purchasers,
by written notice to the other parties, if the Closing has not been consummated on or before the tenth (10th) Trading
Day following the date hereof; provided, however, that no such termination will affect the right of any party to sue for any breach
by any other party (or parties).

 

7.2             
Governing Law; Waiver of Jury Trial. This Agreement shall be governed by and construed in accordance with the Laws
of the State of New York, without regard to the conflict of laws principles thereof that would require the application of the
Law of any other jurisdiction, provided, that (i) the issue of the Purchased Shares as described in Section 2.1, (ii) the transfer
of the Purchased Shares as described in Section 2.2, (iii) Section 3.2(a) to the extent relating to the Company, (iv) the capitalization
of the Company as described in Section 3.4(a) and (v) Section 3.5, to the extent relating to the Company (clauses (i) through
(v) above, jointly, the “Cayman Law Matters”), shall be governed exclusively by, and construed in accordance
with, the laws of the Cayman Islands, without regard to the conflict of laws principles thereof that would require the application
of the Law of any other jurisdiction. The parties irrevocably and unconditionally submit to the exclusive jurisdiction of the
United States District Court for the Southern District of New York solely and specifically for the purposes of any action or proceeding
arising out of or in connection with this Agreement, provided that the courts of the Cayman Islands shall have exclusive jurisdiction
over the Cayman Law Matters. EACH OF THE PARTIES TO THIS AGREEMENT HEREBY AGREES THAT JURISDICTION AND VENUE IN ANY SUIT, ACTION
OR PROCEEDING BROUGHT BY ANY PARTY ARISING OUT OF OR RELATING TO THIS AGREEMENT (INCLUDING ANY SUIT, ACTION OR PROCEEDING SEEKING
EQUITABLE RELIEF) SHALL PROPERLY AND EXCLUSIVELY LIE IN THE STATE AND FEDERAL COURTS LOCATED IN THE STATE OF NEW YORK OR, IN ACCORDANCE
WITH THIS SECTION 7.2, THE COURTS OF THE CAYMAN ISLANDS (THE “CHOSEN COURTS”). EACH PARTY HERETO FURTHER AGREES
NOT TO BRING ANY SUCH SUIT, ACTION OR PROCEEDING IN ANY COURT OTHER THAN THE CHOSEN COURTS PURSUANT TO THE FOREGOING SENTENCE
(OTHER THAN UPON APPEAL). BY EXECUTION AND DELIVERY OF THIS AGREEMENT, EACH PARTY IRREVOCABLY SUBMITS TO THE JURISDICTION OF THE
CHOSEN COURTS FOR ITSELF AND IN RESPECT OF ITS PROPERTY WITH RESPECT TO SUCH SUIT, ACTION OR PROCEEDING. THE PARTIES HERETO IRREVOCABLY
AGREE THAT VENUE WOULD BE PROPER IN EACH OF THE CHOSEN COURTS, AND HEREBY WAIVE ANY OBJECTION THAT ANY SUCH CHOSEN COURT IS AN
IMPROPER OR INCONVENIENT FORUM FOR THE RESOLUTION OF SUCH SUIT, ACTION OR PROCEEDING. TO THE EXTENT NOT PROHIBITED BY APPLICABLE
LAW WHICH CANNOT BE WAIVED, EACH PARTY HERETO HEREBY WAIVES AND COVENANTS THAT IT WILL NOT ASSERT (WHETHER AS PLAINTIFF, DEFENDANT
OR OTHERWISE) ANY RIGHT TO TRIAL BY JURY IN ANY FORUM IN RESPECT OF ANY ISSUE OR ACTION, CLAIM, CAUSE OF ACTION OR SUIT (IN CONTRACT,
TORT OR OTHERWISE). INQUIRY, PROCEEDING OR INVESTIGATION ARISING OUT OF OR BASED UPON THIS AGREEMENT OR THE SUBJECT MATTER HEREOF
OR IN ANY WAY CONNECTED WITH OR RELATED OR INCIDENTAL TO THE TRANSACTIONS CONTEMPLATED HEREBY, IN EACH CASE WHETHER NOW EXISTING
OR HEREAFTER ARISING. EACH PARTY HERETO ACKNOWLEDGES THAT IT HAS BEEN INFORMED BY THE OTHER PARTIES HERETO THAT THIS SECTION 7.2
CONSTITUTES A MATERIAL INDUCEMENT UPON WHICH THEY ARE RELYING AND WILL RELY IN ENTERING INTO THIS AGREEMENT. ANY PARTY HERETO
MAY FILE AN ORIGINAL COUNTERPART OR A COPY OF THIS SECTION 7.2 WITH ANY COURT AS WRITTEN EVIDENCE OF THE CONSENT OF EACH SUCH
PARTY TO THE WAIVER OF ITS RIGHT TO TRIAL BY JURY.

 

    24

     

    

 

7.3             
Survival. The representations, warranties, covenants and agreements made herein shall survive the Closing.

 

7.4             
Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit
of, and be binding upon the parties hereto and their respective successors, assigns, heirs, executors and administrators and shall
inure to the benefit of and be enforceable by each person who shall be a holder of the Purchased Shares from time to time; provided,
however, that prior to the receipt by the Company of adequate written notice of the transfer of any Shares specifying the full
name and address of the transferee, the Company may deem and treat the person listed as the holder of such Shares in its records
as the absolute owner and holder of such Shares for all purposes. This Agreement may not be assigned by any party hereto without
the consent of the other party, provided, that a Purchaser may assign its rights and obligations hereunder in whole or in part
to any Affiliate of such Purchaser or to any successor of such Purchaser as a result of a Change of Control of such Purchaser,
provided further, that in the case of such assignment the assignee shall agree in writing to be bound by the provisions of this
Agreement and such Purchaser shall not be relieved of its obligations hereunder.

 

7.5             
Entire Agreement. This Agreement and the other documents delivered pursuant hereto constitute the full and entire understanding
and agreement between the parties with regard to the subjects hereof and no party shall be liable for or bound to any other in
any manner by any oral or written representations, warranties, covenants and agreements except as specifically set forth herein
and therein.

 

7.6             
Severability. In the event one or more of the provisions of this Agreement should, for any reason, be held to be invalid,
illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions
of this Agreement, and this Agreement shall be construed as if such invalid, illegal or unenforceable provision had never been
contained herein. Upon such determination that any provision of this Agreement, or the application of any such provision, is invalid,
illegal, void or unenforceable, the Company and such Purchaser shall negotiate in good faith to modify this Agreement so as to
effect the original intent of the Company and the Purchasers as closely as possible to the fullest extent permitted by Law in
an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the greatest extent possible.

 

    25

     

    

 

7.7             
Amendment. No provision in this Agreement shall be supplemented, deleted or amended except in a writing executed by
an authorized representative of each of the Purchasers and the Company. Any amendment effected in accordance with this Section
7.7 shall be binding upon each holder of Purchased Shares or Deposit Shares purchased under this Agreement at the time outstanding,
each future holder of all such Shares or Deposit Shares, and the Company, and any amendment not effected in accordance with this
Section 7.7 shall be void and of no effect.

 

7.8             
Waivers; Delays or Omissions. It is agreed that no delay or omission to exercise any right, power or remedy accruing
to any party, upon any breach, default or noncompliance by another party under this Agreement, shall impair any such right, power
or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein,
or of or in any similar breach, default or noncompliance thereafter occurring. It is further agreed that any Consent of any kind
or character on any party’s part of any breach, default or noncompliance under this Agreement or any waiver on such party’s
part of any provisions or conditions of the Agreement must be in writing and shall be effective only to the extent specifically
set forth in such writing. All remedies, either under this Agreement, by Law, or otherwise afforded to any party, shall be cumulative
and not alternative. Any waiver effected in accordance with this Section 7.8 shall be binding upon each holder of Purchased Shares
or Deposit Shares purchased under this Agreement at the time outstanding, each future holder of all such Shares or Deposit Shares,
and the Company, and any waiver not effected in accordance with this Section 7.8 shall be void and of no effect.

 

7.9             
Equitable Relief.  Each of the Company and the Purchasers hereby acknowledges and agrees that the failure of the
Company or the Purchasers to perform their respective agreements and covenants hereunder will cause irreparable injury to the
Purchasers or the Company, for which damages, even if available, will not be an adequate remedy. Accordingly, each of the Company
and the Purchasers hereby agrees that the Purchasers and the Company shall be entitled to seek the issuance of equitable relief
by any court of competent jurisdiction to compel performance of the Company’s or the Purchasers’ obligations.

 

7.10          
Notices. All notices and other communications under this Agreement must be in writing and are deemed duly delivered
when (a) delivered if delivered personally or by nationally recognized overnight courier service (costs prepaid), (b) sent by
facsimile with confirmation of transmission by the transmitting equipment (or, the first Business Day following such transmission
if the date of transmission is not a Business Day) or (c) received or rejected by the addressee, if sent by United States of America
certified or registered mail, return receipt requested; in each case to the following addresses or facsimile numbers and marked
to the attention of the individual (by name or title) designated below (or to such other address, facsimile number or individual
as a party may designate by notice to the other parties) at the address as set forth on the signature pages attached hereto.

 

    26

     

    

 

7.11          
 Expenses. Each party shall pay all costs and expenses that it incurs with respect to the negotiation, execution, delivery
and performance of this Agreement. The Company shall pay all costs, expenses, fees and taxes in connection with (i) the preparation
and filing of the Registration Statement, the Prospectus, the Prospectus Supplement and any amendments or supplements thereto,
and the printing and furnishing of copies of each thereof to Purchasers (including costs of mailing and shipment), (ii) the registration,
issue, sale and delivery of the Purchased Shares including any stock or transfer taxes and stamp or similar duties payable upon
the sale, issuance or delivery of the Purchased Shares to Purchasers, (iii) the qualification of the Purchased Shares for offering
and sale under state or foreign laws and the determination of their eligibility for investment under state or foreign law and
(iv) the fees and disbursements of any transfer agent or registrar for the Purchased Shares in the form of Ordinary Shares.

 

7.12          
Titles and Subtitles. The titles of the sections
and subsections of the Agreement are for convenience of reference only and are not to be considered in construing this Agreement.

 

7.13          
Counterparts. This Agreement may be executed in any number of counterparts (including via facsimile, PDF or other electronic
signature), each of which shall be an original, but all of which together shall constitute one instrument.

 

7.14          
Broker’s Fees. Each party hereto represents and warrants that no agent, broker, investment banker, person or
firm acting on behalf of or under the authority of such party hereto is or will be entitled to any broker’s or finder’s
fee or any other commission directly or indirectly in connection with the transactions contemplated herein, except for an advisory
fee to be paid by the Company to its financial advisor. Each party hereto further agrees to indemnify each other party for any
claims, losses or expenses incurred by such other party as a result of the representation in this Section 7.14 being untrue.

 

7.15          
Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer to the masculine, feminine
or neutral, singular or plural, as to the identity of the parties hereto may require. The words “include,” “includes”
and “including” will be deemed to be followed by the phrase “without limitation”. The meanings given to
terms defined herein will be equally applicable to both the singular and plural forms of such terms. All references to “dollars”
or “$” will be deemed references to the lawful money of the United States of America. All exhibits attached hereto
and all other attachments hereto are hereby incorporated herein by reference and made a part hereof.

 

7.16           
Third Party Beneficiaries. None of the provisions of this Agreement shall be for the benefit of or enforceable by any
Third Party, including any creditor of any party hereto. No Third Party shall obtain any right under any provision of this Agreement
or shall by reason of any such provision make any claim in respect of any debt, liability or obligation (or otherwise) against
any party hereto.

 

    27

     

    

 

7.17           
No Strict Construction. This Agreement has been prepared jointly and will not be construed against either party. In
the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly
by the parties hereto, and no presumption or burden of proof shall arise favoring or disfavoring any party hereto by virtue of
the authorship of any provisions of this Agreement.

 

[Signature Page to Follow]

 

    28

     

    

 

In
Witness Whereof, the parties hereto have executed this Agreement as of the date set forth in the first paragraph hereof.

 

BEIGENE,
LTD.

 

	By:		 

	Name:	 
	Title:	 

 

Address for Notice: 

 

BeiGene, Ltd. c/o Mourant Governance
Services

(Cayman) Limited

94 Solaris Avenue, Camana Bay

Grand Cayman KY1-1108

Cayman Islands

Attention: Chief Financial Officer

 

with a copy to:  

 

BeiGene USA, Inc.

55 Cambridge Parkway, Suite 700W

Cambridge, MA 02142

Attention: General Counsel 

 

With a copy to (which shall not constitute
notice):

 

Goodwin Procter LLP

620 Eighth Avenue

New York, NY 10018

Edwin O’Connor, Esq. 

 

     

     

    

 

[PURCHASER SIGNATURE PAGES TO BEIGENE SECURITIES
PURCHASE AGREEMENT]

 

IN WITNESS WHEREOF,
the undersigned has caused this Share Purchase Agreement to be duly executed by its respective authorized signatories as of the
date first indicated above.

 

	Name of Purchaser:	 	 

 

	Signature of Authorized Signatory of Purchaser:	 	 

 

	Name of Authorized Signatory:	 	 

 

	Title of Authorized Signatory:	 	 

 

	Email Address of Authorized Signatory:	 	 

 

	Facsimile Number of Authorized Signatory:	 

 

Address for Notice to Purchaser:

 

 

Address for Delivery of Shares to Purchaser
(if not same as address for notice):

 

 

	Subscription Amount: $	 	 

 

	Purchaser’s Purchased Shares:	 	 

 

	EIN Number:	 	 

 

o
Notwithstanding anything contained in this Agreement to the contrary, by checking this box (i) the obligations of the above-signed
to purchase the securities set forth in this Agreement to be purchased from the Company by the above-signed, and the obligations
of the Company to sell such securities to the above-signed, shall be unconditional and all conditions to Closing shall be disregarded,
(ii) the Closing shall occur by the second (2nd) Business Day following the date of this Agreement and (iii) any condition to
Closing contemplated by this Agreement (but prior to being disregarded by clause (i) above) that required delivery by the Company
or the above-signed of any agreement, instrument, certificate or the like or purchase price (as applicable) shall no longer be
a condition and shall instead be an unconditional obligation of the Company or the above-signed (as applicable) to deliver such
agreement, instrument, certificate or the like or purchase price (as applicable) to such other party on the Closing Date.

 

[SIGNATURE PAGES CONTINUE]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00311-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00311-of-00352.parquet"}]]