Document:

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                                                                     Exhibit 4.3

                                AMENDMENT TO THE
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT

               This Amendment to the Information and Registration Rights
Agreement (the "Amendment") is made as of October 11, 1990, by and among
Biosource Genetics Corporation, a California corporation (the "Company") and the
persons listed on the attached Schedule A, including amendments thereto, who
become signatories to this Amendment (collectively, the "Investors").

                                 R E C I T A L S

               A. The Company and the Investors have entered into the
Information and Registration Rights Agreement dated as of March 29, 1990 (the
"Agreement") providing for the rights of the Investors with respect to
registration of the shares of Common Stock issuable upon conversion or exercise
of the Company's convertible securities.

               B. The Company and the Investors desire to amend the Agreement to
grant to certain persons acquiring up to 142,858 shares of Series C Preferred
Stock of the Company on or after September 1, 1990, for a total aggregate
consideration of $7.00 per share, or approximately $1 million, certain
preferential registration rights in connection with a piggyback registration
pursuant to Section 4 of the Agreement.

               THE PARTIES AGREE AS FOLLOWS:

               1. Definitions. The Capitalized terms used in this Amendment
without definition shall have the same meanings as set forth in the Agreement.

               2. Grant of Preferential Piggyback Registration Rights.
Notwithstanding anything contained in the Agreement to the contrary, including,
without limitation, to provisions of Sections 4.2 and 9 of the Agreement, in the
event that the Underwriter's Representative advises that the number of shares of
Registrable Securities which may be included in a piggyback Registration must be
limited because of market factors, the Holders of the Registrable Securities
issued upon conversion of up to 142,858 shares of Series C Preferred Stock of
the Company acquired on or after September 1, 1990, at a price of $7.00 per
share or for a total aggregate consideration of approximately $1 million (the
"Preferential C Shares"), shall be entitled to include any or all of such
Preferential C Shares in such piggyback Registration before any other Holder of
any other Registrable Securities shall be entitled to include any Registrable
Securities in such piggyback Registration. In the event that the Underwriter's
Representative limits the number of shares to be included in a piggyback
Registration to a number which is less than the number of Preferential C Shares,
the number of Preferential C Shares which may be included by any Holder thereof
in any such piggyback Registration shall be allocated among the Holders of
Preferential C Shares, in proportion, as nearly as practicable, to the
respective nether of Preferential C Shares held by the Holders thereof at the
time of the filing of the Registration Statement. The provisions of this Section
3 shall not be construed so as to require the inclusion of any Registrable
Securities (including any Preferential C Shares) in a piggyback Registration if
such Registrable Securities (including any Preferential C Shares) would
otherwise be entirely excluded in accordance with the provisions of Section
4.2.2 of the Agreement.

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               3. Registration Rights Granted to Other Securities. From and
after the date of this Amendment, the Company shall not enter into any agreement
with any holder or prospective holder of any securities of the Company providing
for the granting to such holder of any information or registration rights,
except that additional holders may be added as parties to the Agreement subject
to this Amendment with regard to any and all Registrable Securities of the
Company held by them. The additional parties and the additional Registrable
Securities shall be identified in an amendment to Schedule A to the Agreement
and to this Amendment.

               4. Governing Law. This Amendment shall be governed by and
construed in accordance with the laws of the State of California applicable to
contracts entered into and wholly to be performed within the state of California
by California residents.

               5. Counterparts. This Amendment may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

               6. Headings. The headings of the Sections of this Amendment are
for convenience and shall not by themselves determine the interpretation of this
Amendment.

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        IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the day and year first above written.

THE COMPANY:*                              Biosource Genetics Corporation

                                           By: /s/ Robert L. Erwin
                                              ----------------------------------
                                              Robert L. Erwin, President

THE INVESTORS:*

* Original signature pages and Schedule A are on file at the offices of the
  Company.

                                       3<PAGE>   1
                                                                     Exhibit 4.4

                             SECOND AMENDMENT TO THE
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT

               This Second Amendment to the Information and Registration Rights
Agreement, as amended (the "Amendment"), is made as of October 10, 1991, by and
among Biosource Genetics Corporation, a California corporation (the "Company"),
and the persons listed on the attached Schedule A, including amendments thereto,
who become signatories to this Amendment (collectively, the "Investors").

                                 R E C I T A L S

               A. The Company and the Investors have entered into agreements for
sale by the Company and purchase by the Investors of the Company's Convertible
Securities.

               B. The Company and the Investors desire to provide for the rights
of the Investors with respect to registration of the shares of common stock (the
"Common Stock") issued upon conversion of the Company's Series D Preferred Stock
and upon conversion of the Company's warrants issued together with the Company's
Series D Preferred Stock (the "Warrants") according to the terms of the
Information and Registration Rights Agreement dated as of October 11, 1990, as
amended by the Amendment to the Information and Registration Rights Agreement
dated as of October 11, 1990 (together, the "Agreement").

               C. The Company and the Investors desire to amend the Agreement to
grant to certain persons acquiring up to 750,000 shares of Series D Preferred
Stock of the Company and Warrants to purchase up to 750,000 shares of the
Company's Common Stock collectively, the "Series D Investors") on or after
October 10, 1991, for a total aggregate consideration of $6.00 per share and
$1.00 per Warrant, or approximately $5,250,000, Registration rights in
accordance with the Agreement.

               THE PARTIES AGREE AS FOLLOWS:

               1. Definitions. The Capitalized terms used in this Amendment
without definition shall have the same meanings as set forth in the Agreement.

               2. Grant of Registration Rights. In accordance with Section 9 of
the Agreement, each of the Series D Investors hereto shall be considered an
Investor for all purposes of the Agreement.

               3. Counterparts. This Amendment may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

               4. Governing Law. This Amendment shall be governed by and
construed in accordance with the laws of the state of California applicable to
contracts entered into and wholly to be performed within the state of California
by California residents.

               5. Headings. The headings of the Sections of this Amendment are
for convenience and shall not by themselves determine the interpretation of this
Agreement.

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        IN WITNESS WHEREOF, the parties hereto have executed this Amendment as
of the day and year first above written.

THE COMPANY:*                              Biosource Genetics Corporation

                                           By: /s/ Kevin J. Ryan
                                              ----------------------------------
                                              Kevin J. Ryan, President

THE INVESTORS:*

* Original signature pages and Schedule A are on file at the offices of the
  Company.

                                       2<PAGE>   1
                                                                     Exhibit 4.5

                             THIRD AMENDMENT TO THE
                  INFORMATION AND REGISTRATION RIGHTS AGREEMENT

               This Third Amendment to the Information and Registration Rights
Agreement, as amended (the "Amendment"), is made as of March 23, 1998, by and
among Biosource Technology, Inc., a California corporation (the "Company"), and
the persons listed on the attached Schedule A, including amendments thereto, who
become signatories to this Amendment (collectively, the "Investors").

                                 R E C I T A L S

               A. The Company and the Investors have entered into agreements for
sale by the Company and purchase by the Investors of the Company's Convertible
Securities.

               B. The Company and the Investors desire to provide for the rights
of the Investors with respect to registration of the shares of common stock (the
"Common Stock") issued upon conversion of the Company's Series F Preferred Stock
according to the terms of the Information and Registration Rights Agreement
dated as of October 11, 1990, as amended by the Amendment to the Information and
Registration Rights Agreement dated as of October 11, 1990 and the Second
Amendment to the Information and Registration Rights Agreement dated October 10,
1991 (collectively, the "Agreement").

               C. The Company and the Investors desire to amend the Agreement to
grant to certain persons acquiring up to one million (1,000,000) shares of
Series F Preferred Stock of the Company, (the "Series F Investors") on or after
March 6, 1998, for a total aggregate consideration of $7.00 per share, or
approximately $7,000,000, Registration Rights in accordance with the Agreement.

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               THE PARTIES AGREE AS FOLLOWS:

               1. Definitions. The capitalized terms used in this Amendment
without definition shall have the same meanings as set forth in the Agreement.

               2. Grant of Registration Rights. In accordance with Section 9 of
the Agreement, each of the Series F Investors hereto shall be considered an
Investor for all purposes of the Agreement.

               3. Counterparts. This Amendment may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

               4. Governing Law. This Amendment shall be governed by and
construed in accordance with the laws of the state of California applicable to
contracts entered into and wholly to be performed within the state of
California.

               5. Headings. The headings of the Sections of this Amendment are
for convenience and shall not by themselves determine the interpretation of this
Agreement.

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               IN WITNESS WHEREOF, the parties hereto have executed this
Amendment as of the day and year first above written.

THE COMPANY:                         BIOSOURCE TECHNOLOGIES, INC.

                                     By: /s/ Robert L. Erwin
                                        ----------------------------------------
                                        Robert L. Erwin, Chairman of the Board
                                        and Chief Executive Officer

INVESTOR:

                                     -------------------------------------------
                                     Type or Print Name of Investor

                                     -------------------------------------------
                                     Signature of Investor

                                     -------------------------------------------
                                     Type or Print Name and Title of Signer
                                     (if applicable)

              Signature Page for Third Amendment to the Information
                        and Registration Rights Agreement

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