Document:

Exhibit 10.16

 

* Confidential
Treatment Requested by Celera Corporation*

 

AMENDMENT
No. 3 to AGREEMENT

BETWEEN

TIIE REGENTS OF THE UNIVERSITY OF CALIFORNIA

AS MANAGEMENT AND OPERATIONS CONTRACTOR

FOR THE LAWRENCE BERKELEY NATIONAL LABORATORY

AND

BERKELEY HEARTLAB,

A CALIFORNIA CORPORATION

 

The parties hereby agree to amend the Agreement as
follows:

 

1.                                 Revise Appendix A (February 6,
1997) with the attached Statement of Work and “BHL Project Timetable and Reporting Schedule”

 

2.                                 Revise Article II.
Term and Termination to include the termination date April 30, 1999.

 

3.                                 Revise Article III.
Cost to reduce the estimated work contemplated to $[* * * ].

 

4.             All other terms and conditions remain unchanged and in
full force and effect.

 

In witness whereof the
parties hereto have executed this Amendment to the Agreement.

 

 

	
  UNIVERSITY OF CALIFORNIA 

  AS MANAGEMENT AND 

  OPERATIONS CONTRACTOR 

  FOR THE LAWRENCE 

  BERKELEY NATIONAL 

  LABORATORY 

  	
   

  	
  REQUESTOR: Berkeley HeartLab 

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  By

  	
  /s Rick M. Inada 

  	
   

  	
  By

  	
  /s/ Frank Ruderman 

  
	
  Title

  	
  Senior Contracts Office 

  	
   

  	
  Title

  	
  CEO 

  
	
  Name

  	
  Rick M. Inada 

  	
   

  	
  Name

  	
  Frank Ruderman 

  
	
  Date

  	
  10/22/98

  	
   

  	
  Date

  	
  10/21/98

  
											

 

 

* Confidential Treatment Requested by Celera Corporation*

 

Appendix
A

Amendment
3

 

Statement of Work

 

Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) will:

 

1.)            Further
develop and perfect [* * *]

 

2.)            Provide support and
assistance to the clinical laboratory of BHL as needed for quality assurance, technical needs, and transfer
of technology involving new or modified clinical laboratory tests.

 

3.)            Continue
responsibility for the pickup and disposal of hazardous chemical waste at the
clinical laboratory:

 

Staff:

 

LBNL
staff members responsible for the work in this contract include:

 

Ronald M. Krauss, M.D., Principal Investigator

Patricia J. Blanche, Scientist and Leader, Lipoprotein
Analysis Core Laboratory

Laura G. Holl, Principal Research Associate

Joseph R. Orr, Senior Research Associate

Robin S. Rawlings, R.N., Clinical Coordinator,
Cholesterol Research Center

Diane L. Tribble, Ph.D., Staff Scientist

Linda D. Abe, Database Manager

 

LBNL will notify BHL if staff members change.

 

Space

 

The primary site for the conduct of this research shall
be within that occupied by the Cholesterol Research Center (currently 3101 Telegraph
Avenue, Berkeley, CA).  The

 

February 11, 1998

 

 

*
Confidential Treatment Requested by Celera Corporation*

 

Appendix A Revision for
Amendment No. 3

 

Statement of Work

 

Ernest
Orlando National Laboratory will further develop and [* * *]  Performance, progress, and advance payments,
will be monitored in accordance with the attached BHL, Project Timetable and
Reporting Schedule.

 

The
primary site for the conduct of this research shall be within that occupied by
the Cholesterol Research Center (currently 3101 Telegraph Avenue,
Berkeley, CA).  The lease for this space
shall be held by BHL.  If BHL elects to
renegotiate the lease with the owner, or to lease space elsewhere, the amount of
space made available to  LBNL will be determined by mutual
agreement of BHL and LBNL.  While
occupying this space, LBNL will provide support to the clinical laboratory of
Berkeley HeartLab (BHL).  This support will
be determined by mutual agreement of BHL and LBNL for quality assurance,
technical needs, and transfer of technology involving new or modified clinical
laboratory tests.

 

 

* Confidential Treatment Requested by Celera Corporation*

 

BHL Project Timetable and
Reporting Schedule

 

Weeks

 

	
  Project Phase

  	
   

  	
  1

  	
   

  	
  2

  	
   

  	
  3

  	
   

  	
  4

  	
   

  	
  5

  	
   

  	
  6

  	
   

  	
  7

  	
   

  	
  8

  	
   

  	
  9

  	
   

  	
  10

  	
   

  	
  11

  	
   

  	
  12

  	
   

  	
  13

  	
   

  	
  14

  	
   

  	
  15

  	
   

  	
  16

  	
   

  	
  17

  	
   

  	
  18

  	
   

  	
  19

  	
   

  	
  20

  	
   

  	
  21

  	
   

  	
  22

  	
   

  	
  23

  	
   

  	
  24

  	
   

  
	
  Software Devel

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Instrumentation

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Reagent Testing

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Sample Analysis

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Data Analysis

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Testing

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Gel Devel

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Report Software

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Instrument evaluation

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

Advance Payment Schedule

 

	
  Week 1 

  	
   

  	
  $[***]

  	
   

  	
   

  	
  It is understood that work will not commence until
  the first advance payment has been received by LBNL.  It is further understood that reports will
  occur at the intervals outlined below. 
  Work will not begin on the next interval until the advance for that
  interval has been received.  Before the
  commencement of the last interval, beginning Week 19, a full review of the
  progress will be made.  Any adjustment,
  if required, of the benchmark, reporting, and/or advance payments will be
  negotiated before the commencement of the last interval.

  
	
  Week 7 

  	
   

  	
  $[***]

  	
   

  	
   

  
	
  Week 13 

  	
   

  	
  $[***]

  	
   

  	
   

  
	
  Week 19 

  	
   

  	
  $[***]

  	
   

  	
   

  
	
  Total

  	
   

  	
  $[***]

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  

 

PROJECT REPORTING INTERVALS

 

Work Commences the Week of
October 19, 1998

 

	
  Project Reporting:

  	
   

  	
  [***]

  	
   

  

 

4Exhibit 10.17

 

* Confidential Treatment Requested by Celera Corporation*

 

AMENDMENT No. 4 to
AGREEMENT

BETWEEN

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

AS MANAGEMENT AND OPERATIONS CONTRACTOR

FOR THE LAWRENCE BERKELEY NATIONAL LABORATORY

AND

BERKELEY HEARTLAB,

A CALIFORNIA CORPORATION

 

The parties hereby agree to amend the Agreement as follows:

 

1.               Revise Appendix A, “BHL Project Timetable
and Reporting Schedule”

 

2.               Revise Article II.
Term and Termination to extend the termination date July 31,
1999.

 

3.               All
other terms and conditions remain unchanged and in full force and effect.

 

In witness whereof the parties hereto have executed this Amendment to
the Agreement.

 

	
  UNIVERSITY
  OF CALIFORNIA

  	
  REQUESTOR:
  Berkeley HeartLab

  
	
  AS MANAGEMENT AND
  OPERATIONS

  	
   

  
	
  CONTRACTOR FOR THE LAWRENCE BERKELEY NATIONAL LABORATORY

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  By

  	
   

  	
  By

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Title

  	
   

  	
  Title

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Name

  	
   

  	
  Name

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Date

  	
   

  	
  Date

  	
   

  
										

 

 

Appendix A

Amendment 4

 

* Confidential
Treatment Requested by Celera Corporation*

 

Statement
of Work

 

Statement of Work:

 

Ernest Orlando Lawrence Berkeley National Laboratory (LBNL) will:

 

1.) Further develop and perfect [* * *]

 

2.) Provide support and
assistance to the clinical laboratory of BHL as needed for quality assurance,
technical needs, and transfer of technology involving new or modified clinical laboratory tests.

 

3.) Continue responsibility for the pickup and
disposal of hazardous chemical waste at the clinical laboratory.

 

Staff:

 

LBNL staff members responsible for the work in this contract include:

 

Ronald M. Krauss, M.D., Principal Investigator

Patricia J. Blanche, Scientist and Leader, Lipoprotein
Analysis Core Laboratory

Laura
G. Holl, Principal Research Associate

Joseph R. Orr, Senior Research Associate

Craig Ikami, Computer/Instrumentation Engineer

TBA, Research Associate

 

August 26, 1998

 

 

Appendix A

Amendment 4

 

* Confidential
Treatment Requested by Celera Corporation*

 

Space

 

The primary site for the conduct of this research
shall be within that occupied by the Cholesterol Research Center (currently 3101 Telegraph
Avenue, Berkeley, CA).  The lease for this space
shall be held by BHL.  If BHL elects to
renegotiate the lease with the owner, or to lease space elsewhere, the amount
of space made available to LBNL will be determined by mutual agreement of BHL and LBNL.

 

Reporting

 

Performance, progress, and anticipated costs, will be
monitored by monthly reports to the Chief Executive Officer and President,
BHL.  Any future changes in the scope of
work will be subject to approval by both parties, and subject to a fully
executed amendment
reflecting the changes.

 

	
  August 26, 1998

  	
   

  

 

2

 

* Confidential
Treatment Requested by Celera Corporation*

 

 

P.I:
R.M. KRAUSS

 

	
   

  	
   

  	
  Berkeley HeartLab

  	
   

  	
  %

  	
   

  	
  FY 98/99

  Budget

  	
   

  
	
   

  	
   

  	
  ACCT: 8814-01

  	
   

  	
   

  	
   

  	
  PENDING

  	
   

  
	
  Labor

  	
   

  	
  Krauss, R - 9794

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Blanche, P -
  9787

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Holl, L - 9785

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Orr, J - 9783

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Ikami, C - 9786

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  TBA - Res Assoc

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
  [Mixed?] Labor

  	
   

  	
  LBL Labor

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Personnel total

  	
   

  	
  [***]

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Equipment

  	
   

  	
  Equipment

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  R&D
  Subcontracts to $500K

  	
   

  	
  R&D Subcontracts

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Stores/Material
  to $500K

  	
   

  	
  Stores/Matr <$500K

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Low Value
  Division

  	
   

  	
  Low Value Division

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Low Value
  Central

  	
   

  	
  Low Value Central

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Blanket Orders

  	
   

  	
  Blankets-Sigma etc.

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Purchases

  	
   

  	
  Purchases >$2,500

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Consulting/Personal
  Serv.

  	
   

  	
  Blankets/Serv/Main

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Campus Personnel

  	
   

  	
  Campus Personnel

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Support Burden

  	
   

  	
  Support Burden

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Animal Care

  	
   

  	
  Animal Care

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  LBL Computers

  	
   

  	
  LBL Computers

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Miscellaneous

  	
   

  	
  Miscellaneous

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Shipping/Freight

  	
   

  	
  Shipping/Freight

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  T.I.D.

  	
   

  	
  T.I.D.

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  Telephone

  	
   

  	
  Telephone

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Y98 Rates effec
  10/1/97

  	
   

  	
  Total Direct Costs

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
   

  	
  Sci Burden

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
   

  	
  Support Burden

  	
   

  	
   

  	
   

  	
  —

  	
   

  
	
  [* * *]

  	
   

  	
  Procur Burden & Fee

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
  < 

  	
   

  	
  500 Purchase Fee

  	
   

  	
   

  	
   

  	
  —

  	
   

  
	
  [* * *]

  	
  > 

  	
   

  	
  500 Purchase Fee

  	
   

  	
   

  	
   

  	
  —

  	
   

  
	
  [* * *]

  	
   

  	
  Matr Handling Chrg

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
   

  	
  Site Support

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
   

  	
  Regular G&A

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
  [* * *]

  	
   

  	
  Space

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Total Indirect
  Costs

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  TOTAL COSTS

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  Total
  Funds Available

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
  Continued
  Funding

  	
   

  	
   

  	
   

  	
  [***]

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  TOTAL BALANCE

  	
   

  	
   

  	
   

  	
  [***]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00141-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00141-of-00352.parquet"}]]