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Third Amendment to License Agreement

 EXHIBIT 10.42 
 THIRD AMENDMENT TO LICENSE AGREEMENT 
 THIS THIRD AMENDMENT TO LICENSE
AGREEMENT (hereinafter referred to as this “Third Amendment”) is made and entered into this 1A/4” day of August, 2005, by and between GEORGIA TECH RESEARCH CORPORATION, a non-profit corporation organized and existing under the laws of
the State of Georgia and with offices at Georgia Institute of Technology, 505 Tenth Street, Atlanta, Georgia 30332-0415 (hereinafter referred to as “GTRC”), and SaluMedica, LLC, a Georgia corporation with offices at 112 Krog Street, Suite
4, Atlanta, Georgia 30307 (hereinafter referred to as “SM”), formerly known as Restore Therapeutics, Inc. 
 W I T N E S S E T H:

 WHEREAS, GTRC and SM entered into that certain License Agreement, dated the 5th day of March, 1998, pursuant to which
GTRC granted SM certain rights in and to an invention entitled “Poly (Vinyl Alcohol) Cryogel” and the methods employed in the production thereof (hereinafter referred to as the “Invention”), which is the subject of GTRC Invention
Disclosure No. 1837, (hereinafter referred to as “License Agreement”) and incorporated herein by reference; and 
 WHEREAS, GTRC
and SM entered into the FIRST AMENDMENT TO LICENSE AGREEMENT on the 18th day of November, 1998; and 
 WHEREAS, GTRC and SM
entered into the SECOND AMENDMENT TO LICENSE AGREEMENT on the 28th day of February, 2005; and 
 WHEREAS, GTRC and SM have agreed to further
amend the terms of said License Agreement in order to give SM the ability to further commercialize the Technology (as defined in the License Agreement); and 
 NOW THEREFORE, in consideration of mutual covenants and agreements set forth herein and the sum of one dollar ($1.00) paid to GTRC by SM, the receipt and sufficiency of which are hereby
acknowledged, and intending to be legally bound, GTRC and SM do hereby mutually agree to amend the License Agreement as follows: 
 1. Subsection 2.1 of the License Agreement is hereby amended by deleting the first sentence thereof in its entirety and inserting a new first sentence in lieu thereof as follows: 
 “2.1 With respect to the Technology and to the full extent of GTRC’s rights therein, GTRC hereby grants to SM an
exclusive, transferable, royalty-free license, with a right of sublicense, to make, have made, sell, offer for sale, distribute, have distributed, promote, develop, modify, and use Products throughout the Territory.” 
 2. Subsection 4.1 of the License Agreement as modified by Section 1 of the Second Amendment to License Agreement is hereby amended
by deleting it in its entirety and inserting a new Subsection 4.1 in lieu thereof as follows: 

 “4.1 Subject to the provisions of this Article 4, the rights granted
to SM in Article 3 may be sublicensed (any such sublicense grant by SM being herein called a “Tier 1 Sublicense”) and further sublicensed without limit. Each sublicense granted by a holder of a Tier 1 Sublicense is herein called a
“Tier 2 Sublicense;” and each sublicense grant by a holder of a Tier 2 Sublicense is herein called a “Tier 3 Sublicense” and so on. Any Tier 3 Sublicense or further sublicense(s) below a Tier 3 Sublicense shall require delivery
of a notice to GTRC along with a one-time payment per sublicense in the amount of $50,000 made payable to GTRC within thirty (30) days upon execution of such sublicense.” 
 3. The following text is hereby added to the License Agreement as Subsection 4.4: 
 “4.4 GTRC acknowledges that SM has granted or will grant a sublicense to SpineMedica Corp., a Florida corporation
(“SpineMedica”), to, among other things, practice and use the Technology pursuant to the terms set forth in a license agreement (the “Sublicense Agreement”). In accordance with the Sublicense Agreement, the license between SM and
SpineMedica is, among other things, an exclusive, worldwide, fully-paid, royalty-free, irrevocable license, with unlimited right to sublicense, to practice and use the Technology in the field of use consisting of all neurological and orthopedic
uses, including muscular and skeletal uses, related to the human spine (the “Spine Field of Use”); provided, however, that the irrevocable license between SaluMedica and SpineMedica pertains only to the license grant under the Sublicense
Agreement and does not affect GTRC’s rights to revoke the license granted to SaluMedica under this License Agreement. GTRC covenants that if this License Agreement is terminated for any reason other than pursuant to Subsection 18.1, including
termination resulting from the dissolution, liquidation or winding down of SM, GTRC shall grant a license to SpineMedica (or its successors or assigns) to practice and use the Technology in the Spine Field of Use on substantially the same terms as
the license granted to SM under this License Agreement.” 
 4. Subsection 19.1 of the License Agreement is hereby
amended by inserting the following text after the address for SM: 
 “If this License Agreement is terminated for any
reason other than pursuant to Subsection 18.1, then GTRC shall deliver a copy of such notice to SpineMedica at the following address: 
 SpineMedica Corp. 
 1234 Airport Road, Suite 105 
 Destin, Florida 32541 
 Attention: President Facsimile: (805) 650-2213” 
  

 - 2 - 

 Except as amended by the First and Second Amendments, all of the terms and conditions of
the License Agreement, as originally drafted, shall remain in full force and effect. 
 IN WITNESS WHEREOF, SM and
GTRC have caused this Third Amendment of License Agreement to be executed by their duly authorized officers on the day and year first written above. 
  

									
	 SALUMED LLC
	 		 	 GEORGIA TECH RESEARCH CORPORATION

					
	 By:
	 	 /s/ Eric D. Ranney
	 		 	 By:
	 	 /s/ Lauren MacLanahan

		 	 Eric D. Ranney, Manager
	 		 	 Name:
	 	 /s/ Lauren MacLanahan

		 		 		 	 Title:
	 	 Technology Licensing Associate

					
	 By:
	 	 /s/ Robert B. Braden
	 		 	 By:
	 	 /s/ G. Duane Hutchinson

		 	 Robert B. Braden, Manager
	 		 	 Name:
	 	 G. Duane Hutchinson

		 		 		 	 Title:
	 	 Asst. Secretary & Ass. Treasurer

  

 - 3 -Assignment of Invention and Non-Provisional Patent Application

 EXHIBIT 10.43 
 ASSIGNMENT OF INVENTION 
 AND 
 NON-PROVISIONAL PATENT APPLICATION 
 WHEREAS, David N.
Ku, having a personal address at 1943 Grist Stone Court, Atlanta, GA 30307, Atlanta, Georgia (hereinafter referred to as ASSIGNOR), is an inventor of an invention entitled “FLEXIBLE SPINAL DISC” as described in the specification
forming part of an application for United States letters patent; and 
 WHEREAS, SaluMedica, LLC (hereinafter referred
to as ASSIGNEE), a Georgia limited liability company, having a place of business at 112 Krog Street, Suite 4, Atlanta, Georgia 30307, is desirous of acquiring the entire right, title and interest in and to the invention and in and to any letters
patent that may be granted therefor in the United States and in any and all foreign countries; 
 NOW, THEREFORE, in exchange
for good and valuable consideration including the sum of ten dollars ($10.00) paid to ASSIGNOR by ASSIGNEE, the receipt of which is hereby acknowledged, ASSIGNOR hereby sells, assigns and transfers unto said ASSIGNEE, the entire right, title and
interest in and to said invention, said application and any and all letters patent which may be granted for said invention in the United States of America and its territorial possessions and in any and all foreign countries, and in any and all
divisions, reissues and continuations thereof, including the right to file foreign applications directly in the name of ASSIGNEE and to claim priority rights deriving from said United States application to which said foreign applications are
entitled by virtue of international convention, treaty or otherwise, said invention, application and all letters patent on said invention to be held and enjoyed by ASSIGNEE and its successors and assigns as fully and entirely as the same would have
been held and enjoyed by ASSIGNOR had this assignment, transfer and sale not been made. ASSIGNOR hereby authorizes and requests the Commissioner of Patents and Trademarks to issue all letters patent on said invention to ASSIGNEE. ASSIGNOR agrees to
execute all instruments and documents required for the making and prosecution of applications for United States and foreign letters patent on said invention, for litigation regarding said letters patent, or for the purpose of protecting title to
said invention or letters patent therefor. 
  

					
	 August 11, 2005
	  		  	 /s/ David N. Ku

	 Date
	  		  	 David N. KuAssignment of Inventrion and Non-Provisional Patent Application

 EXHIBIT 10.44 
 ASSIGNMENT OF INVENTION 
 AND 
 NON-PROVISIONAL PATENT APPLICATION 
 WHEREAS, SaluMedica,
LLC, having a place of business at 112 Krog Street, Suite 4, Atlanta, Georgia 30307 (hereinafter referred to as ASSIGNOR), is the owner of an invention entitled “FLEXIBLE SPINAL DISC” as described in the specification
forming part of an application for United States letters patent, Application Number 10/658,932; 
 WHEREAS, pursuant to a
prior assignment, David N. Ku (“KU”) assigned all of his entire right, title and interest in and to said invention, said application and all other rights related thereto to ASSIGNOR; and 
 WHEREAS, SpineMedica Corp. (hereinafter referred to as ASSIGNEE), a Florida corporation, having a place of business at 1234
Airport Road, Suite 105, Destin, Florida 32541, is desirous of acquiring the entire right, title and interest in and to the invention and in and to any letters patent that may be granted therefor in the United States and in any and all foreign
countries; 
 NOW, THEREFORE, in exchange for good and valuable consideration including the sum of ten dollars ($10.00) paid
to ASSIGNOR by ASSIGNEE, the receipt of which is hereby acknowledged, ASSIGNOR hereby sells, assigns and transfers unto said ASSIGNEE, the entire right, title and interest in and to said invention, said application and any and all letters patent
which may be granted for said invention in the United States of America and its territorial possessions and in any and all foreign countries, and in any and all divisions, reissues and continuations thereof, including the right to file foreign
applications directly in the name of ASSIGNEE and to claim priority rights deriving from said United States application to which said foreign applications are entitled by virtue of international convention, treaty or otherwise, said invention,
application and all letters patent on said invention to be held and enjoyed by ASSIGNEE and its successors and assigns as fully and entirely as the same would have been held and enjoyed by ASSIGNOR had this assignment, transfer and sale not been
made. ASSIGNOR hereby authorizes and requests the Commissioner of Patents and Trademarks to issue all letters patent on said invention to ASSIGNEE. ASSIGNOR agrees to execute, and agrees to cause Ku to execute (to the extent it can control Ku’s
acts), all instruments and documents required for the making and prosecution of applications for United States and foreign letters patent on said invention, for litigation regarding said letters patent, or for the purpose of protecting title to said
invention or letters patent therefor. 

 IN WITNESS WHEREOF, the undersigned have executed this assignment on behalf of ASSIGNOR.

  

					
	 August 12, 2005
	 		 	 /s/ Eric D. Ranney

	 Date
	 		 	 Eric D. Ranney

		 		 	 Manager

		 		 	 SALUMEDICA, LLC

			
	 August 12, 2005
	 		 	 /s/ Robert B. Braden

	 Date
	 		 	 Robert B. Braden

		 		 	 Manager

		 		 	 SALUMEDICA, LLC

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