Document:

EXHIBIT 4.40
                                                                    ------------

                                   30 May 2002

                          (1) CENES PHARMACEUTICALS PLC

                    (2) CAMBRIDGE COGNITION GUARANTEE LIMITED

                               (3) M&R 850 LIMITED

                         (4) CAMBRIDGE COGNITION LIMITED

                   -------------------------------------------

                                    AGREEMENT

                     for the sale and purchase of shares in

                           CAMBRIDGE COGNITION LIMITED
                   -------------------------------------------

                             WEIL, GOTSHAL & MANGES

                         One South Place London EC2M 2WG
               Tel: +44 (0) 20 7903 1000 Fax: +44 (0) 20 7903 0990

                                  www.weil.com

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                                TABLE OF CONTENTS

                                                                          Page

1        INTERPRETATION....................................................2

2        SALE AND PURCHASE.................................................7

3        CONSIDERATION.....................................................7

4        CONDITIONS........................................................7

5        COMPLETION........................................................8

6        POST-COMPLETION OBLIGATIONS.......................................9

7        WARRANTIES........................................................9

8        LIMITATIONS ON WARRANTY CLAIMS...................................10

10       ANNOUNCEMENTS....................................................12

11       ASSIGNMENT.......................................................12

12       RIGHTS OF THIRD PARTIES..........................................12

13       VARIATION........................................................13

14       WAIVER...........................................................13

15       ENTIRE AGREEMENT.................................................13

16       COSTS............................................................13

17       COUNTERPARTS.....................................................13

18       NOTICES..........................................................14

19       GOVERNING LAW....................................................15

20       JURISDICTION.....................................................15

SCHEDULE 1 INFORMATION ABOUT THE COMPANY AND MDCL.........................16

Part A The Company........................................................16

Part B MDCL...............................................................17

SCHEDULE 2 DETAILS OF SELLERS AND THEIR SHAREHOLDINGS.....................18

SCHEDULE 3 WARRANTIES.....................................................19

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THIS AGREEMENT is made on 30 May 2002 between the following parties:

(1)      CENES PHARMACEUTICALS PLC, a company incorporated in Scotland
         (registered number SC166791) whose registered office is at Riverside
         Business Park, Irvine, Ayrshire KA11 5DJ ("CeNeS");

(2)      CAMBRIDGE COGNITION GUARANTEE LIMITED, a company incorporated in
         England and Wales (registered number 04234029), whose registered office
         is at Compass House, Vision Park, Chivers Way, Histon, Cambridge CB4
         9ZR ("CCGL");

(3)      M&R 850 LIMITED a company incorporated in England and Wales (registered
         number 4338746), whose registered office is at 112 Hills Road,
         Cambridge CB2 1PH (the "Buyer"); and

(4)      CAMBRIDGE COGNITION LIMITED a company incorporated in England and Wales
         (registered number 4213437) whose registered office is at Compass
         House, Vision Park, Chivers Way, Histon, Cambridge CB4 9ZR (the
         "Company").

RECITALS

(A)      The Company was incorporated in England and Wales on 10 May 2001 under
         the Companies Acts 1985 and 1989 with registered number 04213437 and is
         a private company limited by shares.

(B)      On 2 July 2001 the Cognition Business (as defined below) was sold by
         CeNeS Limited to the Company under the terms of a business and asset
         transfer agreement of the same date (the "Cognition Transfer
         Agreement").

(C)      On 2 July 2001, the Company purchased the MDC Business from Dr Jean
         Hammond and Dr John Hammond under the terms of a business and asset
         transfer agreement of the same date (the "MDC Transfer Agreement").

(D)      The Sellers have agreed to sell and the Buyer has agreed to buy the
         Shares (as defined below) for the Consideration (as defined below) and
         upon the terms and subject to the conditions set out in this Agreement
         (the "Transaction").

IT IS AGREED as follows:

1        INTERPRETATION

1.1      In this Agreement, the following expressions have the following
         meanings:

         "Business Day"           means any day other than a Saturday or Sunday
                                  on which banks are normally open for general
                                  business in London;

         "Business Sale"          means the sale of the whole or substantially
                                  the whole of the business and assets of the
                                  Company (whether by the Company itself or by
                                  another Buyer's Group Company to whom assets
                                  have been sold or transferred) to a third
                                  party for consideration in excess
                                  of(pound)5,000,000 which shall include any
                                  deferred consideration and any guaranteed
                                  payments or royalties on the sale of products

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                                  or the use of processes by the Buyer;

         "Buyer's Group"          means the Buyer and any subsidiary or parent
                                  undertaking of the Buyer and any subsidiary of
                                  such parent from time to time;

         "Buyer's Group Company"  means the Company, its holding company or a
                                  subsidiary of the Buyer or its holding
                                  company;

         "Buyer's Solicitors"     means Mills & Reeve of 112 Hills Road,
                                  Cambridge CB2 1PH;

         "CANTAB"                 means the Cambridge Neuropsychological Test
                                  Automated Battery ;

         "CANTAB Licence"         means the licence to be granted to CeNeS
                                  Limited by the Company in the agreed form in
                                  respect of CANTAB at Completion;

         "CeNeS Loan"             means the sum of (pound)372,073 as at 30 May
                                  2002 which CeNeS has advanced to the Company
                                  by way of an unsecured inter company loan;

         "Claim"                  means a claim by the Buyer for a breach of
                                  Warranty;

         "Cognition Business"     means the Cognition business comprising the
                                  manufacture, research, development and sale of
                                  hardware, software, consultancy and other
                                  general services related to cognitive function
                                  carried on by CeNeS Limited on 2 July 2001 and
                                  transferred to the Company pursuant to the
                                  Cognition Transfer Agreement;

         "Completion"             means completion of the sale and purchase of
                                  the Shares in accordance with Clause 5 of this
                                  Agreement;

         "Conditions"             means the conditions set out in Clause 4;

         "Consideration"          means the consideration payable for the Shares
                                  as set out in Clause 3;

         "Disclosure Letter"      means the letter in an agreed form dated the
                                  date of this Agreement from the Sellers to the
                                  Buyer for the purpose of making disclosures
                                  against the Warranties in accordance with
                                  Clause 7.3;

         "Encumbrance"            means a mortgage, charge, pledge, lien,
                                  option, restriction, right of set off, right
                                  of first refusal, third party right or
                                  interest or other security interest securing
                                  any obligation of any person or other
                                  arrangement or agreement having similar effect

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                                  in existence prior to the Completion Date;

         "Intellectual            means the intellectual property owned by,
         Property Rights"         developed by and/or transferred to the Company
                                  as described in the Cognition Transfer
                                  Agreement and the MDC Transfer Agreement and
                                  shall further include but not be limited to
                                  all patents, trademarks, trade names, services
                                  marks, registered designs, design rights,
                                  copyright, know-how and all other intellectual
                                  property whether or not registered or capable
                                  of registration and applications for the same
                                  and whether subsisting in the United Kingdom
                                  or any other part of the world together with
                                  all or any goodwill relating thereto;

         "Listing"                means the becoming effective of a listing of
                                  any class of share in the capital of the
                                  Buyer's Group Company on the Official List of
                                  the United Kingdom Listing Authority or the
                                  granting of permission for any of the Buyer's
                                  Group Company's shares to be dealt in on a
                                  Recognised Investment Exchange (as defined in
                                  Section 285 of the Financial Services and
                                  Markets Act 2000) and including, without
                                  limitation, the NASDAQ Europe, the Alternative
                                  Investment Market of the London Stock Exchange
                                  plc, NASDAQ and any other exchange which will
                                  provide an immediate liquid market for shares
                                  in the relevant Buyer's Group Company in all
                                  cases where the market capitalisation of the
                                  Buyer's Group Company on the impact date of
                                  the listing is in excess of(pound)5,000,000;

         "MDC Business"           means the business operated by Dr Jean Hammond
                                  and Dr John Hammond under the name Management
                                  Dynamics Cambridge and transferred to the
                                  Company on 2 July 2001 pursuant to the MDC
                                  Transfer Agreement comprising organisational
                                  psychology consultancy;

         "MDCL"                   means Management Dynamics Cambridge Limited;

         "Managers"               means Dr Jean Hammond, Dr John Hammond, Huw
                                  Jones and Hamish Miller;

         "Sale"                   means the sale of the entire issued share
                                  capital of the Buyer or the Company or a
                                  Buyers Group Company to which the business and
                                  assets of the Company has been transferred for
                                  a consideration in excess of(pound)5,000,000,
                                  and including any deferred consideration which

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                                  shall include any guaranteed payments or
                                  royalties on the sale of products or the use
                                  of processes by the buyer however satisfied;

         "Sale of a               means the sale of an interest in shares (as
         Controlling Interest"    defined in Schedule 13, Part 1 and Section 324
                                  of the Companies Act 1985) of the Buyer or the
                                  Company or a Buyers Group Company to which the
                                  business and assets of the Company has been
                                  transferred conferring in aggregate 50 per
                                  cent. or more of the total voting rights
                                  conferred by all the issued shares of the
                                  Buyer or the Company or a Buyers Group Company
                                  to which the business and assets of the
                                  Company has been transferred where the
                                  acquisition values the total issued equity of
                                  the Buyer or the Company or a Buyers Group
                                  Company to which the business and assets of
                                  the Company has been transferred as in excess
                                  of (pound)5,000,000;

         "Sellers"                means CeNeS and CCGL;

         "Sellers' Solicitors"    means Weil, Gotshal & Manges of One South
                                  Place, London EC2M 2WG;

         "Shares"                 means the 8,699 of fully-paid ordinary shares
                                  of (pound)1 each of the Company held by CeNeS
                                  and the 1 fully-paid ordinary share of
                                  (pound)1 of the Company held by CCGL,
                                  comprising approximately 87 per cent. of the
                                  allotted and issued share capital of the
                                  Company;

         "Tangible Net Asset      means the value of the assets of the Company
          Value"                  (other than intangible assets as defined by
                                  FRS 10) shown in the balance sheet of the
                                  Company as at Completion (being the cost of
                                  such assets less aggregate depreciation to
                                  date) together net of the current liabilities
                                  of the Company at the relevant date at cost;

         "Tax" or "Taxation"      shall have the meaning set out in the Tax
                                  Deed;

         "Tax Claim"              means any claim by the Buyer against the
                                  Sellers for breach of any of the tax
                                  warranties set out in Schedule 3, Part 2 of
                                  this Agreement or under the Tax Deed;

         "Tax Deed"               means a deed relating to Taxation made between
                                  the Sellers and the Buyer in the agreed form;

         "VAT"                    means value added tax as provided for in the

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                                  VATA and other tax of a similar nature;

         "VATA"                   means in the UK, the Value Added Tax Act 1994
                                  and, in a jurisdiction outside the UK, any
                                  equivalent legislation;

         "Warranty"               means a statement set out in Schedule 3 and
                                  "Warranties" means all such statements.

1.2      In this Agreement:

         1.2.1    a "subsidiary undertaking" or "parent undertaking" is to be
                  construed in accordance with S258 of the Act and a
                  "subsidiary" or "holding company" is to be construed in
                  accordance with S736 of the Act;

         1.2.2    references to a "person" include an individual, body corporate
                  (wherever incorporated), unincorporated association, trust or
                  partnership (whether or not having separate legal
                  personality), government, state or agency of a state, or two
                  or more of the foregoing;

         1.2.3    references to a document in the "agreed form" are to that
                  document in the form agreed to and initialled for the purposes
                  of identification by or on behalf of the parties;

         1.2.4    references to a clause or schedule are to a clause or schedule
                  of this Agreement, and references to this Agreement include
                  the schedules and the schedules form part of this Agreement
                  and will have the same effect as if in the body of this
                  Agreement;

         1.2.5    the headings in this Agreement do not affect its construction
                  or interpretation;

         1.2.6    references to a statute or a statutory provision are to
                  include references to such statute or provision as amended or
                  re-enacted whether before or after the date of this Agreement
                  and include all subordinate legislation made under the
                  relevant statute whether before or after the date of this
                  Agreement save where that amendment or re-enactment would
                  extend or increase the liability on any party under this
                  Agreement;

         1.2.7    a reference to a document is a reference to that document as
                  amended or modified from time to time in writing by the mutual
                  consent of the parties;

         1.2.8    a person shall be deemed to be connected with another if that
                  person is connected with another within the meaning of section
                  839 of the Taxes Act;

         1.2.9    the singular includes the plural and vice versa and any gender
                  includes any other gender;

         1.2.10   the "winding-up", "dissolution" or "administration" of a
                  company or corporation shall be construed so as to include any
                  equivalent or analogous proceedings under the law of the
                  jurisdiction in which such company or corporation is
                  incorporated or any jurisdiction in which such company or
                  corporation carries on business, including proceedings whereby
                  liquidation, winding-up, reorganisation, dissolution,

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                  administration, arrangement, adjustment, protection or
                  debtor's relief is sought;

         1.2.11   All obligations of the Sellers under this Agreement, including
                  any liability in respect of any Claims or any other breach of
                  this Agreement, are joint and several.

2        SALE AND PURCHASE

2.1      Each of the Sellers agrees to sell with full title guarantee and free
         from any Encumbrance and the Buyer agrees to buy the Shares set
         opposite that Sellers name in column 2 of Schedule 2, with all rights
         attaching or accruing to the Shares as at or after the date of this
         Agreement including all rights to any dividends or other distributions
         paid after the execution of this Agreement.

2.2      The Buyer shall not be obliged to purchase any of the Shares unless the
         purchase of all the Shares is completed simultaneously.

2.3      Title to, and beneficial ownership of, the Shares shall pass on
         Completion.

3        CONSIDERATION

3.1      The consideration for the sale and purchase of the Shares shall be the
         sum of(pound)1,000,000 (one million pounds) of which:-

         3.1.1    (pound)500,000 (five hundred thousand pounds) shall be due and
                  payable to the Sellers by telegraphic transfer on the
                  Completion Date to the account detailed in Clause 5.3.1;

         3.1.2    (pound)200,000 (two hundred thousand pounds) shall be due and
                  payable to the Sellers by telegraphic transfer on the second
                  anniversary of Completion to the account detailed in Clause
                  5.3.1 (the "Second Instalment");

         3.1.3    (pound)300,000 (three hundred thousand pounds) shall be due
                  and payable to the Sellers by telegraphic transfer within five
                  Business Days of the first to occur of the following events to
                  the account detailed in Clause 5.3.1:

                  (a)      a Sale;

                  (b)      a Sale of a Controlling Interest;

                  (c)      a Business Sale; or

                  (d)      a Listing;

3.2      Notwithstanding Clause 3.1, in the event of a Sale, Business Sale or
         the Sale of a Controlling Interest, to the extent that the Second
         Instalment has not been made such payment shall be made by the Buyer to
         the Sellers within 5 Business Days from the date of such event.

4        CONDITIONS

4.1      Completion is conditional on the following conditions being satisfied
         on or before the date set for Completion in Clause 5.1:

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         4.1.1    the execution of a subscription agreement between the Buyer
                  and certain investors to raise (pound)1,565,000 by the issue
                  of new shares in the capital of the Buyer; and

         4.1.2    the execution of a waiver of any right of pre-emption (if
                  applicable) by the shareholders of the Company (including the
                  Sellers) in respect of the transfer of the Shares to the
                  Buyer.

5        COMPLETION

5.1      Subject to satisfaction of the conditions set out in Clause 4
         Completion shall take place at the office of the Buyers' Solicitors on
         30 May 2002.

5.2      At Completion, the Sellers shall deliver or procure the delivery to the
         Buyer or the Buyer's Solicitors of the following:

         5.2.1    duly executed transfers of the Shares to the Buyer and the
                  relevant share certificates;

         5.2.2    an executed irrevocable power of attorney in favour of the
                  Buyer empowering the Buyer to exercise the Sellers' rights as
                  shareholders of the Company pending stamping and registration
                  of the transfers referred to in 5.2.1;

         5.2.3    resignation letters in the agreed form signed by Neil Clark in
                  respect of the Company and MDCL acknowledging that Neil Clark
                  has no claim against the Company and/or MDCL in respect of
                  breach of contract, compensation for loss of office,
                  redundancy or unfair dismissal or on any other grounds
                  whatsoever;

         5.2.4    the Disclosure Letter duly executed by each Seller;

         5.2.5    the CANTAB Licence duly executed by CeNeS Limited; and

         5.2.6    a counterpart of the Tax Deed duly executed by the Sellers.

5.3      At Completion:

         5.3.1    the Buyer shall pay (pound)500,000 (five hundred thousand
                  pounds) by way of telegraphic transfer of funds to the account
                  set out below or such other account as the Sellers shall have
                  specified in writing to the Buyer prior to Completion and
                  shall provide the Sellers' counterpart of the Tax Deed duly
                  executed by the Buyer.

                     Bank:          Barclays Bank plc

                     Address:       Broadgate Corporate Banking Centre
                                    155 Bishopsgate
                                    London
                                    EC2M 3XA

                     Account no:    10366900

                     Sort code:     20-19-90

                     Account name:  Weil, Gotshal & Manges

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         5.3.2    the Buyer shall deliver to CeNeS the CANTAB Licence duly
                  executed by the Company;

         5.3.3    the Seller shall procure that duly convened meetings are held
                  at which the transfers referred to in Clause 5.2.1 are
                  approved, subject only to stamping, for registration in the
                  books of the Company;

         5.3.4    all existing instructions to the bankers of the Company are
                  revoked and new instructions given in such form as the Buyer
                  directs.

6        POST-COMPLETION OBLIGATIONS

6.1      The Sellers hereby jointly and severally warrant that as at Completion
         the Tangible Net Asset Value shall not be less than(pound)205,000.

6.2      Within 14 days of Completion the Buyer shall calculate the Tangible Net
         Asset Value and deliver a copy together with the calculations to the
         Sellers for the attention of Neil Clark. The Sellers shall have 14 days
         from delivery of such to agree the Tangible Net Asset Value failing
         which an independent accountant shall be appointed by agreement between
         the parties and in the absence of agreement by the President for the
         time being of the Institute of Chartered Accountants who shall act as
         an independent expert and not as arbiter, who shall apply the
         accounting principals used by the accountants of CeNeS in preparing the
         statutory accounts of CeNeS and whose decision shall be binding on the
         parties. The costs of such expert shall follow the determination.

6.3      In the event that the Tangible Net Asset Value shall be less than
         (pound)190,000 the Seller shall, unless otherwise agreed between the
         parties, repay to the Buyer any difference between the Tangible Net
         Asset Value and (pound)190,000 and the Consideration shall be abated
         accordingly.

6.4      The Buyer shall, following Completion, provide CeNeS with a copy of the
         Buyer's Group monthly management accounts at the end of each financial
         quarter, commencing with effect for the period ending 30 June 2002,
         until such time as the Consideration has been fully paid.

6.5      With effect from Completion, the Sellers shall release and write off
         the CeNeS Loan.

6.6      The Sellers shall, following Completion, give the Buyer access to
         information, documents and records as the Buyer may reasonably require
         for the purposes only of fulfilling its compliance obligations in
         respect of Taxation.

7        WARRANTIES

7.1      The Warranties are given by each of the Sellers as set out in this
         Agreement at the date of this Agreement.

7.2      Each of the Sellers warrants to the Buyer that each Warranty is true
         and accurate and not misleading at the date of this Agreement and that
         the Buyer is entering this Agreement in reliance on each of the
         Warranties.

7.3      The Warranties are qualified by matters fairly disclosed in the
         Disclosure Letter and for this purpose "fairly disclosed" means
         disclosed in such manner as to enable the Buyer to make a fair
         assessment of the nature of the matters concerned.

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7.4      Each of the Warranties shall be construed as a separate and independent
         warranty and (except where this Agreement provides otherwise) shall not
         be limited or restricted in its scope by reference to or inference from
         any other term of another Warranty or this Agreement.

7.5      Where a Warranty is qualified by the expression "so far as the Sellers
         are aware", or "to the best of the knowledge of the Sellers", or any
         similar expression, the awareness of the Sellers is limited to the
         knowledge of the Sellers having made reasonable enquiries only of the
         Managers, Neil Clark and the Company's audit partner of Arthur Andersen
         at the date hereof.

7.6      Each of the Sellers agrees with the Buyer:

         7.6.1    to waive any right or claim which he may have against the
                  Company and/or any of its directors, employees agents or
                  advisers for any error, omission or misrepresentation in any
                  such information or opinion; and;

         7.6.2    that any such right or claim shall not constitute a defence to
                  any claim by the Buyer under or in relation to this Agreement
                  (including the Warranties).

8        LIMITATIONS ON WARRANTY CLAIMS

8.1      Subject to Clause 8.2 the aggregate liability of the Sellers for all
         Claims and Tax Claims shall not exceed (pound)1,000,000.

8.2      The Sellers liability for all Claims and Tax Claims may not exceed the
         amount actually received from the Buyer pursuant to Clause 3. In the
         event that a Claim or Tax Claim for which the Sellers are liable under
         the terms of this Agreement exceeds the consideration received under
         and pursuant to Clause 3 (the "Excess") to the extent that further
         payments become due to the Sellers, the Buyer may offset the Excess
         against the payment of the sum due. In the event that the condition for
         the payment of a sum under Clause 3 is not satisfied and there is an
         Excess the Buyer will have no right to claim the Excess from the
         Sellers.

8.3      The Sellers shall not be liable for any Claim or Tax Claim:

         8.3.1    unless the aggregate amount of any Claim or Tax Claim shall
                  exceed (pound)50,000 (in which case the Buyer shall be
                  entitled to claim the whole of such sum and not merely the
                  excess);

         8.3.2    unless the amount of any individual Claim or Tax Claim,
                  described in Clause 8.3.1, together with all such other claims
                  exceeds (pound)10,000. For the avoidance of doubt, amounts for
                  which the Sellers have no liability as a consequence of the
                  operation of this Clause, shall not be capable of constituting
                  a Claim or Tax Claim or increasing the amount of such Claim or
                  Tax Claim for the purpose of this Clause;

         8.3.3    unless the Buyer notifies the Sellers in writing in reasonable
                  detail of the Claim or Tax Claim on or before the expiry of 24
                  months from Completion and 6 years from Completion in the case
                  of a Tax Claim.

         8.3.4    which is not satisfied, settled or withdrawn within 6 months
                  of the date of notification of such Claim or Tax Claim under
                  paragraph 8.2.3 unless proceedings in respect of it have been

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                  commenced by being both issued and served on the Buyers or
                  formal alternative dispute resolution procedures have been
                  commenced with the Buyers. Time shall be of the essence for
                  this purpose.

8.4      The amount of the liability for each of the Sellers in respect of any
         Claim or Tax Claim shall not exceed such proportion of the amount of
         the Claim or Tax Claim as the consideration receivable by each under
         this Agreement bears to the total amount of the consideration
         receivable by all of the Sellers under this Agreement.

8.5      The limitations set out and referred to in Clauses 8.1, 8.2 and 8.3 do
         not apply to a breach of any Warranty resulting from fraud or in
         respect of a Warranty, set out in paragraph 1 of Schedule 3.

8.6      If the Buyer becomes aware of a matter which is likely to give rise to
         a Claim or Tax Claim or of any claim, action or demand against it or
         matter likely to give rise to any of these which may result in a Claim
         (a "Third Party Claim"), the Buyer shall:

         8.6.1    as soon as reasonably practicable thereafter give notice
                  thereof in writing to the Sellers, stating in reasonable
                  detail the nature of the matter on a without prejudice basis,
                  if practicable, the amount claimed, and the provisions of this
                  Agreement which the Buyer alleges have been or may have been
                  breached;

         8.6.2    make available to accountants and other professional advisers
                  appointed by the Sellers such access to the personnel of the
                  Company and to any relevant records and information as the
                  Sellers reasonably request in connection with such Claim or
                  Tax Claim or Third Party Claim; and

         8.6.3    use its reasonable endeavours to procure that the auditors
                  (both past and then current) of the Company make available
                  their audit working papers in respect of audits of the
                  Company's accounts for any relevant accounting period in
                  connection with such Claim or Tax Claim or Third Party.

8.7      If the Buyer becomes aware of a Third Party Claim of which notice has
         been or may be given by the Buyer under Clause 8.6.1, the Buyer shall,
         subject to being indemnified by the Sellers against all reasonable
         costs and liabilities incurred in doing so:

         8.7.1    take or procure such action to be taken as the Sellers shall
                  reasonably request (having regard in particular to the Buyer's
                  continuing business) to avoid, dispute, resist, appeal,
                  compromise or defend such Third Party Claim or any
                  adjudication in respect of a Third Party Claim;

         8.7.2    if so requested by the Sellers maintain consultation with the
                  Sellers on all aspects of any proceedings in defence of a
                  Third Party Claim;

         8.7.3    not admit liability in respect of a Third Party Claim, nor
                  compromise, nor settle any proceedings in defence of a Third
                  Party Claim, without the written consent of the Sellers (such
                  consent not to be unreasonably withheld or delayed);

         8.7.4    if so required by the Sellers in writing, ensure (or, as
                  appropriate, shall co-operate to procure that the Company
                  shall ensure), at the request in writing of the Sellers, that
                  the Sellers are placed in a position to take on or take over
                  the conduct of all proceedings and/or negotiations of
                  whatsoever nature arising in connection with the Third Party

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                  Claim in question and provide (or, as appropriate, co-operate
                  to procure that the Company provides) such information and
                  assistance as the Sellers may reasonably require in connection
                  with the preparation for and conduct of such proceedings
                  and/or negotiations provided that the Sellers shall, if
                  requested, by the Buyer:

                  (a)      maintain consultation with the Buyer on all aspects
                           of any proceedings in defence of a Third Party Claim
                           and take into account all reasonable requests of the
                           Buyer in relation to the conduct of such Third Party
                           Claim;

                  (b)      not admit liability in respect of a Third Party Claim
                           nor compromise nor settle any proceedings in defence
                           of a Third Party Claim without the prior written
                           consent of the Buyer (such consent not to be
                           unreasonably withheld or delayed).

8.8      The Buyer is not entitled to recover more than once in respect of any
         one matter giving rise to a Claim or a Tax Claim whether pursuant to
         this Agreement or otherwise. For the avoidance of doubt the Sellers
         shall not be liable under this Agreement in respect of any Claim if any
         adjustment is made to the Consideration pursuant to Clause 6 in respect
         of the matter or thing giving rise to the Claim.

9        RESTRICTIVE COVENANTS

9.1      Each of the Sellers hereby undertakes with each of the Company and the
         Buyer that neither it nor any of its subsidiary undertakings nor its
         parent undertaking shall for the duration of this Agreement and for a
         period of 12 months following termination or expiry of this Agreement
         for any reason whatsoever carry on or be engaged or interested in or in
         any way assist in the research, development or the supply of goods or
         services which is similar to or which conflicts or competes with
         research and development work or the supply of goods or services
         relating to the Cognition Business or any other business of the Company
         conducted during such period provided that this shall not prohibit the
         holding (directly or through nominees) of investments listed on the
         London Stock Exchange plc or any recognised investment exchange as long
         as not more than 5 per cent. of the issued shares or other securities
         of any class of any one company shall be so held.

9.2      Each of the Sellers hereby undertakes with each of the Company and the
         Buyer that it shall not at any time during this Agreement and for a
         period of 12 months following termination or expiry of this Agreement
         for any reason whatsoever either solely or jointly with or as agent for
         any person, directly or indirectly canvass or solicit for employment or
         employ any person who is, or has at any time whilst the Sellers have
         held shares in the Company, been an employee of the Company or
         endeavour to induce any such person to cease being an employee of the
         Company.

9.3      Each undertaking contained in this clause 9 shall be construed
         independently so that if one or more should be held to be invalid to
         any extent as an unreasonable restraint of trade or for any other
         reason then it shall be valid to the extent that it is not held to be
         so invalid and the rest shall remain unaffected and shall apply with
         such modifications as may be necessary to make the rest valid and
         effective.

                                       12
<PAGE>

10       ANNOUNCEMENTS

10.1     Subject to Clause 10.2, no announcement or public statement concerning
         the existence, subject matter or any term of this Agreement shall be
         made by or on behalf of any party without the prior written approval of
         the other such approval not to be unreasonably withheld or delayed.

10.2     This Clause shall not apply to any announcement or public statement by
         any party required by law, or the rules of any regulatory or
         governmental body to which such party is subject, including the rules
         of a recognised investment exchange (as defined in the Financial
         Services and Markets Act 2000) any stock exchange on which any
         securities of the relevant party are listed, in which case the party
         concerned shall make all reasonable attempts to agree the contents of
         such announcement or statement with the other party before it is made.

11       ASSIGNMENT

         Neither party shall be entitled to assign or transfer all or any of its
         rights, benefits or obligations under this Agreement without the prior
         written consent of the other party.

12       RIGHTS OF THIRD PARTIES

12.1     A person who is not a party to this Agreement has no rights under the
         Contracts (Rights of Third Parties) Act 1999 or otherwise to enforce
         any term of this Agreement but this does not affect any right or remedy
         of a third party which exists or is available apart from the Act.

13       VARIATION

         Any variation of this Agreement must be in writing and signed by each
         party or, in the case of a body corporate, a duly authorised officer or
         representative of such party.

14       WAIVER

         A delay in exercising, or failure to exercise, any right or remedy
         under this Agreement does not constitute a waiver of such right or
         remedy or other rights or remedies nor shall either operate so as to
         bar the exercise or enforcement thereof.

15       ENTIRE AGREEMENT

15.1     Each party acknowledges and agrees that:

         15.1.1   this Agreement constitutes the whole and only agreement and
                  understanding between the parties in connection with the sale
                  of the Shares;

         15.1.2   it has not entered into the Agreement or any of them in
                  reliance on any pre-contractual statement which is not
                  expressly set out in this Agreement and, to the extent any
                  pre-contractual statement was made or given and is not
                  expressly set out in this Agreement, it irrevocably and
                  unconditionally waives any claims, rights or remedies which it
                  may otherwise have in relation to any such pre-contractual
                  statement; and

         15.1.3   the only rights and remedies available to it in connection
                  with the Agreement is damages for breach of contract and, for
                  the avoidance of doubt, no party has any right to rescind

                                       13
<PAGE>

                  (except in the case of fraud) or terminate the Agreement for
                  breach of contract or for negligent or innocent
                  misrepresentation or otherwise except as provided in this
                  Agreement,

         provided always that this clause 15.1 shall not exclude or limit any
         liability or any right which any party may have in respect of
         pre-contractual statements made or given fraudulently or dishonestly in
         circumstances where there has been wilful concealment.

16       COSTS

         Save as otherwise expressly stated in this Agreement, each party shall
         pay its own costs in connection with the negotiation, preparation and
         implementation of this Agreement and all agreements ancillary to it.

17       COUNTERPARTS

         This Agreement may be executed in any number of counterparts, each of
         which when executed and delivered constitutes an original of this
         Agreement, but all the counterparts shall together constitute one and
         the same agreement. No counterpart shall be effective until each party
         has executed at least one counterpart.

18       NOTICES

18.1     A notice or other communication given under this Agreement shall be in
         writing and shall be served by delivering it to the party due to
         receive it at the address set out in this Clause 18 and shall be deemed
         to have been delivered in accordance with this Clause 18.

18.2     The parties' addresses and fax numbers for the purposes of this
         Agreement are:

         M&R 850 Limited
         112 Hills Road
         Cambridge CB2 1PH
         For the attention of :  Hew Jones
         Fax number:  01223 810701

         CeNeS Pharmaceuticals Plc
         Compass House
         Vision Park
         Chivers Way
         Histon
         Cambridge
         CB4 9ZR
         For the attention of :  Neil Clark
         Fax number:  01223 266467

         Cambridge Cognition Guarantee Limited
         Compass House
         Vision Park
         Chivers Way
         Histon
         Cambridge
         CB4 9ZR
         Fax number:  01223 266467

                                       14
<PAGE>

         Cambridge Cognition Limited
         Compass House
         Vision Park
         Chivers Way
         Histon
         Cambridge
         CB4 9ZR

         Fax number:  01223 266467

         or such other address or fax number as the relevant party notifies to
         the other parties, which change of address shall only take effect if
         delivered and received in accordance with this Clause.

18.3     A notice so addressed shall be deemed to have been received:

         18.3.1   if personally delivered, at the time delivery;

         18.3.2   if sent by pre-paid first class post, recorded delivery or
                  registered post, two Business Days after the date of posting
                  to the relevant address;

         18.3.3   if sent by registered air-mail, five Business Days after the
                  date of posting to the relevant address; and

         18.3.4   if sent by fax, on successful completion of its transmission
                  as per a transmission report from the machine from which the
                  fax was sent, save that if such notice of communication is
                  received after the end of normal working hours (and "normal
                  working hours" shall be deemed to be 8.30 am to 5.30 pm on any
                  Business Day in the country of the recipient), such notice or
                  communication shall be deemed to have been received on the
                  next Business Day.

18.4     For the avoidance of doubt, notice given under this Agreement shall not
         be validly served if sent by electronic mail.

19       GOVERNING LAW

         This Agreement is governed by, and shall be construed in accordance
         with, English law.

20       JURISDICTION

         Each party irrevocably agrees that the courts of England have exclusive
         jurisdiction to decide and to settle any dispute or claim arising out
         of or in connection with this Agreement ("Proceedings").

                                       15
<PAGE>

                                   SCHEDULE 1
                     INFORMATION ABOUT THE COMPANY AND MDCL

                                     Part A
                                   The Company
<TABLE>
<S>            <C>                                          <C>
1              Registered number:                           04213437

2              Date of incorporation:                       10/05/01

3              Place of incorporation:                      United Kingdom

4              Registered office address:                   Compass  House,   Vision  Park,  Chivers  Way,  Histon,
                                                            Cambridge, Cambridgeshire  CB4 9ZR

5              Type of company:                             Private Limited Company

6              Authorised share capital:

               (a)      amount:                       (pound)10,000

               (b)      number and class of shares:         10,000 ordinary shares

7              Issued share capital:

               (a)      amount:                       (pound)10,000

               (b)      number and class of shares:         10,000 ordinary shares

8              Directors:                                   Neil Clark,  Dr. John Hammond,  Dr. Jean  Hammond,  Huw
                                                            Jones, Hamish Miller

9              Secretary:                                   Huw Jones

10             Accounting reference date:                   31 December

11             Auditors:                                    Arthur Andersen

12             Outstanding Charges:                         None
</TABLE>

                                       16
<PAGE>

                                     Part B
                                      MDCL

Management Dynamics Cambridge Limited
<TABLE>
<S>          <C>                                            <C>
1            Registered number:                             02853619

2            Date of incorporation:                         15 September 1993

3            Place of incorporation:                        United Kingdom

4            Registered office address:                     Compass  House,  Vision  Park,  Chivers  Way,  Histon,
                                                            Cambridge, Cambridgeshire  CB4 9ZR

5            Type of company:                               Private Limited Company

6            Authorised share capital:

             (a)      amount:                         (pound)1,000

             (b)      number and class of shares:           1,000 Ordinary shares of(pound)1 each

7            Issued share capital:

             (a)      amount:                         (pound)2

             (b)      number and class of shares:           2 Ordinary shares of(pound)1 each

8            Percentage owned by Company                    100%

9            Directors:                                     Neil Clark, Dr. Ernest Hammond

10           Secretary:                                     Neil Clark

11           Accounting reference date:                     31 December

12           Outstanding Charges:                           None
</TABLE>

                                       17
<PAGE>

                                   SCHEDULE 2
                   DETAILS OF SELLERS AND THEIR SHAREHOLDINGS
<TABLE>
<CAPTION>
============================================================ ============================================

                             1                                                    2

                      Name of Seller                          Number of Shares legally and beneficially
                                                                      at date of this Agreement

============================================================ ============================================
<S>                                                                             <C>
CeNeS Pharmaceuticals PLC                                                       8699
------------------------------------------------------------ --------------------------------------------

Cambridge Cognition Guarantee Limited                                             1
============================================================ ============================================
</TABLE>

                                       18
<PAGE>

                                   SCHEDULE 3
                                   WARRANTIES

                                     Part 1

1        Each of the Sellers is the sole legal and beneficial owner of the
         Shares set out opposite his name in Schedule 2 and such Shares are
         owned free of Encumbrances.

2        Each of the Shares have been properly issued and allotted and are fully
         paid or credited as fully paid and the Sellers have at all times prior
         to Completion had the share certificates for the Shares in their
         possession or control.

3        No Agreement or arrangement has been entered into which requires or may
         require the Company to allot, issue or transfer or to grant any person
         the right (whether conditional or otherwise) to call for the allotment,
         issue or transfer of any share or loan capital.

4        Each of the Sellers have full power and authority without requiring the
         consent of any other person, and has taken all necessary corporate or
         other actions, to enter into and exercise its rights and perform its
         obligations under this Agreement and all other documents to be
         exercised by it at Completion.

5        All information set out in this Agreement (including annexures) is
         true, accurate and not misleading in any material respect.

6        So far as the Sellers are aware, since 2 July 2001 ("Accounts Date")
         the Cognition Business has been carried on in the ordinary and usual
         course, without interruption or alteration in nature, scope or manner
         so as to maintain it as a going concern and so far as the Sellers are
         aware there has been no material adverse change in the turnover or
         financial position of the Cognition Business and, so far as the Sellers
         are aware there are no factors likely to have such an effect specific
         to the Cognition Business and not affecting similar businesses.

7        The Company has at all times carried on its business and affairs in all
         respects in accordance with its memorandum and articles of association.

8        All returns, resolutions and other documents required to be filed with
         or delivered to the Registrar of Companies in respect of the Company
         have been properly filed or delivered.

9        The accounting records of the Company have been properly written up on
         a consistent basis and the Company has complied with the obligations
         under section 221 of the Companies Act 1985. All relevant financial
         books and records of the Company are in its possession or otherwise
         under its direct control and are up to date.

10       As far as the Sellers are aware, the Company has not entered into a
         material, unusual or long term contract in connection with the
         Cognition Business.

11       As far as the Sellers are aware, the Company has obtained all material
         licences, permissions and consents and other approvals necessary to
         carry on the Cognition Business, all such licences and consents are
         valid and in full force and effect and not limited in duration so far
         as the Sellers are aware no event has occurred and there has been no
         omission which shall or is reasonably likely to prejudice any such
         licences, permissions, consents or other approvals remaining in full
         force and effect.

                                       19
<PAGE>

12       So far as the Sellers are aware the Company owns or has and will
         following Completion have, the right to use all assets and rights that
         it needs to carry on the Cognition Business as carried on immediately
         prior to Completion.

13       So far as the Sellers are aware no circumstances exist which constitute
         a ground on which any material contract to which the Company is a party
         could be avoided, repudiated, rescinded, prematurely determined or
         declared to be invalid and so far as the Sellers are aware the Company
         has not received any notice of a claim to that effect or notice
         indicating that such a claim is foreseeable.

14       As far as the Sellers are aware, no mortgages, charges, liens,
         encumbrances or other security interests subsist over assets used in
         the Cognition Business save for charges and liens arising in the
         ordinary course of business.

15       So far as the Sellers are aware, no steps been taken or legal
         proceedings been started or threatened against the Company, as the case
         may be, for winding up, dissolution or reorganisation or for the
         appointment of a receiver or administrative receiver or any
         administrator, trustee or similar officer of its assets or revenues and
         no meeting has been convened for the purpose of winding up the Company
         and so far as the Sellers are aware (without making any enquiry of a
         third party) the Company has not been a party to any transaction which
         could be avoided in a winding up.

16       So far as the Sellers are aware (without making any enquiry of a third
         party), the Company has not been party to any transactions at an
         undervalue for the purposes of Section 238 of the Insolvency Act 1986
         nor has it given or received any preference for the purposes of Section
         239 of the Insolvency Act 1986 in either case since the Company's
         incorporation.

17       None of the Sellers is unable to pay its debts as defined in section
         123 of the Insolvency Act 1986 or is the subject of any order for the
         winding up, dissolution or re-organisation or the appointment of a
         receiver or administrative receiver.

18       So far as the Sellers are aware, the Cognition Business has been
         conducted in accordance with applicable law or regulation, so far as
         each Seller is aware the Cognition Business is not in breach of any
         such law or regulation and so far as the Sellers are aware compliance
         has been made with all legal and procedural requirements necessary for
         the Company to undertake the Cognition Business.

19       As far as the Sellers are aware, the Company has maintained up-to-date,
         adequate and suitable records regarding the service and terms and
         conditions of employment, payments of statutory or other sick pay,
         statutory or other maternity pay, disciplinary and health and safety
         matters, income tax and social security contributions and termination
         of employment of each of the Company's employees.

20       So far as the Sellers are aware the Company has not offered to employ
         or engage any person where such employment or engagement will take
         effect after Completion or made, agreed or proposed or entered into
         negotiation or received any request for any change in the terms of
         employment by the Company of any employee where such change is due or
         expected within six months from the date of this Agreement.

21       As far as the Sellers are aware, no employee has given notice or is
         under notice to terminate his employment.

                                       20
<PAGE>

22       The Sellers are not aware of any outstanding claims by any person who
         is now or has been an employee of the Cognition Business or any dispute
         between the Company and any employee or a material number or class of
         the employees of the Cognition Business and no payments are due by the
         Company under the provisions of the Employment Rights Act 1996, the
         Equal Pay Act 1970, the Sex Discrimination Act 1975 and the Race
         Relations Act 1976, the Disability Discrimination Act 1995 and the
         Trade Union and Labour Relations (Consolidation) Act 1992 and so far as
         the Sellers are aware there are no circumstances likely to give rise to
         any such dispute.

23       As far as the Sellers are aware the Company has not entered into any
         recognition agreement with a trade union nor has it done any act which
         might be construed as recognition.

24       So far as the Sellers are aware, no gratuitous payment has been made or
         promised by the Company in connection with the actual or proposed
         termination, breach, suspension or variation of any employment or
         engagement of any present or former director, officer or employee of or
         consultant to the Company.

25       As far as the Sellers are aware, the Company is the sole beneficial
         owner of the Intellectual Property Rights and (where such property is
         registered) is the registered proprietor thereof free from and clear of
         any restriction of use or Encumbrance and so far as the Sellers are
         aware, the Company has not disclosed (except in the ordinary course of
         its business and on the basis that such disclosure is to be treated as
         being confidential in nature) any of the know-how nor any trade secrets
         or list of customers relating to the Cognition Business to any other
         person firm company or organisation.

26       As far as the Sellers are aware, the Company owns or has the right to
         use the copyright in the designs of all the brochures, literature and
         marketing material of the Cognition Business which were transferred
         under the Cognition Transfer Agreement and as far as the Sellers are
         aware, none of the said brochures, literature and marketing material or
         any of the Intellectual Property Rights infringes any intellectual
         property rights of any other person firm or company or involves the
         unauthorised use of confidential information disclosed to the Company
         by any person firm company or organisation.

27       As far as the Sellers are aware, no third party has any right over or
         right to remuneration derived from the commercial exploitation of any
         of the Cognition Intellectual Property Rights.

28       Except in the ordinary and usual course and save as set out in the
         Disclosure Letter, the Company has not granted and is not obliged to
         grant any licences under any Intellectual Property Rights owned by it
         or licensed to it.

29       All application, renewal and other official statutory and regulatory
         fees relating to the administration of the Intellectual Property Rights
         or for the protection and enforcement thereof have been duly paid and
         so far as the Sellers are aware all reasonable steps have been taken
         for their maintenance and protection.

30       Save as set out in the Disclosure Letter, the fixed and loose plant,
         machinery, furniture, fixtures, fittings, equipment, vehicles and all
         other assets used in relation to the Cognition Business of the Company
         are the property of the Company free from any hire or hire-purchase
         agreement or agreement for payment on deferred terms or bill of sale or
         any Encumbrance, and have at all material times been and are in the
         possession of or under the control of the Company in the UK.

                                       21
<PAGE>

31       All plant, machinery vehicles and equipment owned or used by the
         Company is in good repair and condition (fair wear and tear excepted)
         and in working order, has been properly serviced and maintained on a
         regular basis and complies with appropriate safety regulations.

32       As far as the Sellers are aware, the Company has effected all
         insurances required by law to be effected by it and all premiums due on
         the policies in respect of such insurance cover ("the Policies") have
         been paid; so far as the Sellers are aware, all other conditions of the
         Policies have been performed and observed; so far as the Sellers are
         aware none of the Policies has or will be void or voidable as a result
         of an act or omission of the Company and so far as the Sellers are
         aware all Policies will continue in full force and effect
         notwithstanding Completion.

33       Neither of the Sellers is aware of any circumstances which would
         entitle the Company to make a claim under any of the Policies or which
         would be required under any of the Policies to be notified to the
         insurers.

34       So far as the Sellers are aware, the Company has not committed any
         material breach of any agreement to which it is a party which, and no
         party with whom the Company has entered into any agreement is in
         default thereunder being a default which, would have an adverse effect
         on its financial or trading position.

35       So far as the Sellers are aware, there is no liability in respect of
         any claim against the Company arising out of any defect in design,
         material or workmanship of any goods supplied by the Company before
         Completion or out of any error or omission on the part of the Company
         in the supply of any service.

36       Apart from the collection of debts in the ordinary course of the
         business neither the Company nor any person for whose acts the Company
         may be contractually or vicariously liable is engaged in any capacity
         in any litigation, arbitration, prosecution or other legal proceedings
         or in any proceedings or hearings before any statutory or Governmental
         body, department, board or agency; so far as the Sellers are aware no
         such matters are pending or threatened; and the Sellers are not aware
         of any circumstances which are likely to give rise to any such matter.

37       So far as the Sellers are aware, there are no overdraft, loan and other
         financial and leasing facilities available to the Company and so far as
         the Sellers are aware, there is no other indebtedness of the Company
         excluding trade creditors.

38       Complete and accurate copies of all licences, escrow agreements and
         (where the warranties have not expired) development agreements in
         respect of all computer software used or held by the Company have been
         provided or are held by the Buyer. So far as the Sellers are aware, the
         licences of such computer software are complied with in all material
         respects in the operation of the business of the Company.

39       So far as the Sellers are aware, there are adequate maintenance
         provisions in place in relation to the Company's computer systems and
         the maintenance providers concerned have always fulfilled their
         obligations under those agreements in accordance with their terms (and
         those terms provide for the software concerned to be updated free of
         charge and for errors to be corrected).

40       So far as the Sellers are aware, the Company has a prudent disaster
         recovery plan in respect of its computer systems which would permit all
         of the Company's critical functions which are run on the computer

                                       22
<PAGE>

         systems to be restored within 24 hours, the balance of functions being
         restored within 48 hours.

41       So far as the Sellers are aware, all necessary back-up systems are
         utilised to ensure that in the event of any fault in any computer
         system used by the Company, no more than one day's data might be lost.

42       So far as the Sellers are aware, the Company has prudent procedures in
         place to ensure the security of its computer systems and the data
         stored on them.

                                       23
<PAGE>

                                     Part 2

43       As far as the Sellers are aware, all notices, returns, computations and
         payments which should have been made by the Company for any Taxation
         purpose have been made within the requisite time-periods and are
         up-to-date, correct and on a proper basis.

44       As far as the Sellers are aware, the Company is not and does not expect
         to be involved in any dispute with the Inland Revenue or HM Customs &
         Excise concerning any matter likely to affect in any way the liability
         of the Company to Taxation, and so far as the Sellers are aware there
         are no circumstances which are likely to give rise to any such dispute
         for the next twelve months.

45       The Company has not entered into any non-arm's length transaction with
         any shareholder, employee or officer of the Company, present or former,
         or any Company in the same group of companies as the Company for the
         purposes of any form of Taxation.

46       The Company has as far as the Sellers are aware, complied fully with
         all its obligations under the PAYE system and relating to National
         Insurance Contributions in respect of all its present and former
         employees and officers.

47       The Company has not entered into or been party to any scheme or
         arrangement designed wholly or mainly for the purpose of avoiding or
         deferring taxation.

48       The Company:

48.1     is duly registered and is a taxable person for the purposes of VAT and
         has complied with all statutory requirements relating to VAT;

48.2     is not in arrears with any payment or returns under legislation
         relating to VAT;

48.3     has fully maintained complete correct and up to date records, invoices
         and other necessary documents;

48.4     has not been required by HM Customs & Excise to give any security;

48.5     is not and has never been or agreed to be an agent or manager or factor
         or representative for the purposes of section 47 or 48 VATA; and

48.6     has not been a party to any transaction to which paragraph 1 of
         Schedule 6 VATA applies.

49       Neither CeNeS nor the Company has been a relevant company in relation
         to an exempt distribution for the purposes of section 213 ICTA 1988.

50       The Company has sufficient records relating to past events to calculate
         its liability in respect of any form of taxation or relief which would
         arise on any disposal or on the realisation of any of its assets.

51       The Company will not incur any liability to taxation under Section 190
         of the Taxation of Chargeable Gains Act 1992 (tax on one member of a
         group recoverable from another member) by reason of any unsatisfied
         corporation tax liability of any other company.

52       The Company is not under any obligation to make at any time any
         payments of interest or any annual payments for which no relief will be
         received (whether as a deduction or charge on income) by reason of

                                       24
<PAGE>

         Sections 125 (annual payments for non-taxable consideration) or 787
         (restriction of relief for payment of interest) of the Taxes Act 1988
         or by reason of its being a distribution].

53       The Company has not since its incorporation been a party to any
         transaction in respect of which the Company, its officer directors or
         advisers considered that there was a risk that the Company could be
         liable to Taxation under the provisions of Part XVII of the Taxes Act
         1988 (Anti-Avoidance) or as a result of the principles enunciated by
         the House of Lords in Furniss v Dawson 55 TC 324.

54       As far as the Sellers are aware, all documents which are liable to
         stamp duty and which confer any right upon the Company have been duly
         stamped and no document which confers any right upon the Company and
         which is outside the UK would attract duty if it were brought into the
         UK.

                                       25
<PAGE>

EXECUTED by the parties:

Signed by                                    )
for and on behalf of                         )
CENES PHARMACEUTICALS PLC                    )

/s/ Neil Clark
________________________            Signature

Signed by                                    )
for and on behalf of                         )
CAMBRIDGE COGNITION                          )
GUARANTEE LIMITED                            )

/s/ Neil Clark
________________________            Signature

Signed by                                    )
for and on behalf of                         )
M&R 850 LIMITED                              )

/s/ A.H. Jenes
________________________            Signature

Signed by                                    )
for and on behalf of                         )
CAMBRIDGE COGNITION LIMITED                  )

/s/ Neil Clark
________________________            Signature

                                       26EXHIBIT 10.1

REPORT OF INDEPENDENT AUDITORS

To the Shareholders of CeNeS Pharmaceuticals plc:

      We have audited the accompanying consolidated balance sheets of CeNeS
Pharmaceuticals plc (a Company incorporated in Scotland) as of December 31, 2000
and 2001, and the related consolidated statements of operations and
comprehensive losses, statements of changes in shareholders' equity and cash
flows for the year ended August 31, 1999, and the four months ended December 31,
1999 and the years ended December 31, 2000 and 2001. These financial statements
are the responsibility of the Company's management. Our responsibility is to
express an opinion on these financial statements based on our audits. As
explained in note 2, the financial statements have not been prepared for the
purposes of Section 226 of the Companies Act 1985.

      We conducted our audits in accordance with auditing standards generally
accepted in the United States. Those standards require that we plan and perform
the audit to obtain reasonable assurance about whether the financial statements
are free of material misstatement. An audit includes examining, on a test basis,
evidence supporting the amounts and disclosures in the financial statements. An
audit also includes assessing the accounting principles used and significant
estimates made by management, as well as evaluating the overall financial
statement presentation. We believe that our audits provide a reasonable basis
for our opinion.

      In our opinion, the financial statements referred to above present fairly,
in all material respects, the financial position of CeNeS Pharmaceuticals plc as
of December 31, 2000 and 2001, and the results of its operations and its cash
flows for the year ended August 31, 1999, the four months ended December 31,
1999 and the years ended December 31, 2000 and 2001 in conformity with
accounting principles generally accepted in the United States.

/s/ Arthur Andersen

Arthur Andersen
Cambridge, England

Date:  July 10, 2002

                                       1

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