Document:

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                                                                     EXHIBIT 4.2

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR UNDER ANY
STATE SECURITIES LAWS AND MAY NOT BE SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT, OR AN EXEMPTION FROM REGISTRATION, UNDER SAID ACT AND
LAWS.

                          AMENDED AND RESTATED WARRANT

                                   TO PURCHASE

                             SHARES OF COMMON STOCK

                                       OF

                                   ZILA, INC.

                             Expires March 24, 2011

No. 2
                                                                    June 6, 2006

      FOR VALUE RECEIVED, subject to the provisions hereinafter set forth, the
undersigned, Zila, Inc., a Delaware corporation (together with its successors
and assigns, the "Issuer"), hereby certifies that

                               BDC FINANCE, L.L.C.

or its registered assigns is entitled to subscribe for and purchase at an
initial exercise price of $3.14 per share, during the Term (as defined below),
1,200,000 shares of the duly authorized, validly issued, fully paid and
non-assessable Common Stock all subject to adjustment and upon the terms and
conditions as hereinafter provided. Capitalized terms used in this Warrant and
not otherwise defined herein shall have the respective meanings specified in
Section 7 hereof. This Warrant amends and restates that certain warrant to
purchase 1,200,000 shares of Common Stock issued to Black Diamond Commercial
Finance, L.L.C. by the Company on March 24, 2006 and subsequently transferred to
BDC Finance, L.L.C.

      1. Term. The right to subscribe for and purchase shares of Warrant Stock
represented hereby shall commence on the date hereof and shall expire at 5:00
P.M., Eastern Time, on March 24, 2011 (such period being the "Term").

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      2. Method of Exercise; Payment; Issuance of New Warrant; Transfer and
Exchange.

            (a) Time of Exercise. The purchase rights represented by this
Warrant may be exercised in whole or in part at any time and from time to time
during the Term.

            (b) Method of Exercise. The Holder hereof may exercise this Warrant,
in whole or in part, by the surrender of this Warrant (with the exercise form
attached hereto duly executed) at the principal office of the Issuer, and by the
payment to the Issuer of an amount of consideration therefor equal to the
Warrant Price in effect on the date of such exercise multiplied by the number of
shares of Warrant Stock with respect to which this Warrant is then being
exercised, payable at such Holder's election (i) by certified or official bank
check or wire transfer of immediately available funds or (ii) by surrender to
the Issuer for cancellation of a portion of this Warrant representing that
number of unissued shares of Warrant Stock which is equal to the quotient
obtained by dividing (A) the product obtained by multiplying the Warrant Price
by the number of shares of Warrant Stock being purchased upon such exercise by
(B) the difference obtained by subtracting the Warrant Price from the Current
Market Price per share of Warrant Stock as of the date of such exercise, or
(iii) by a combination of the foregoing methods of payment selected by the
Holder of this Warrant. In any case where the consideration payable upon such
exercise is being paid in whole or in part pursuant to the provisions of clause
(ii), such exercise shall be accompanied by written notice from the Holder of
this Warrant specifying the manner of payment thereof and containing a
calculation showing the number of shares of Warrant Stock with respect to which
rights are being surrendered thereunder and the net number of shares to be
issued after giving effect to such surrender.

            (c) Issuance of Stock Certificates. In the event of any exercise of
the rights represented by this Warrant in accordance with and subject to the
terms and conditions hereof, (i) certificates for the shares of Warrant Stock so
purchased shall be dated the date of such exercise and delivered to the Holder
hereof within a reasonable time, not exceeding five Business Days after such
exercise, and the Holder hereof shall be deemed for all purposes to be the
Holder of the shares of Warrant Stock so purchased as of the date of such
exercise, and (ii) unless this Warrant has expired, a new Warrant representing
the number of shares of Warrant Stock, if any, with respect to which this
Warrant shall not then have been exercised including any portion which is not
then exercisable pursuant to Section 5 (less any amount thereof which shall have
been cancelled in payment or partial payment of the Warrant Price as hereinabove
provided) shall also be issued to the Holder hereof within such time.

            (d) Transferability of Warrant; Warrant Stock. Subject to the
provisions of Section 2(e) hereof, this Warrant may be transferred on the books
of the Issuer by the Holder hereof in person or by duly authorized attorney,
upon surrender of this Warrant at the principal office of the Issuer, properly
endorsed (by the Holder executing an assignment in the form attached hereto) and
upon payment of any necessary transfer tax or other governmental charge imposed
upon such transfer. This Warrant is exchangeable at the principal office of the
Issuer for Warrants for the purchase of the same aggregate number of shares of
Warrant Stock, each new Warrant to represent the right to purchase such number
of shares of Warrant Stock as the Holder hereof shall designate at the time of
such exchange. All Warrants issued on transfers

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or exchanges shall be dated the date hereof and shall be identical to this
Warrant except as to the number of shares of Warrant Stock issuable pursuant
hereto.

            (e) Compliance with Securities Laws.

                  (i) The Holder of this Warrant, by acceptance hereof,
acknowledges and agrees that the Holder will not offer, sell or otherwise
dispose of this Warrant or any shares of Warrant Stock to be issued upon
exercise hereof except pursuant to an effective registration statement, or an
exemption from registration, under the Securities Act and any applicable state
securities laws.

                  (ii) This Warrant and all certificates representing shares of
Warrant Stock issued upon exercise hereof shall be stamped or imprinted with a
legend in substantially the following form:

      "THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE HEREOF
      MAY NOT BE SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT, OR
      AN EXEMPTION FROM REGISTRATION, UNDER SAID ACT AND LAWS."

            (f) Continuing Rights of Holder. The Issuer will, at the time of or
at any time after each exercise of this Warrant, upon the request of the Holder
hereof or of any shares of Warrant Stock issued upon such exercise, acknowledge
in writing the extent, if any, of its continuing obligation to afford to such
Holder all rights to which such Holder shall continue to be entitled after such
exercise in accordance with the terms of this Warrant, provided that if any such
Holder shall fail to make any such request, the failure shall not affect the
continuing obligation of the Issuer to afford such rights to such Holder.

            (g) Recapitalization, Reorganization, Reclassification,
Consolidation, Merger or Sale.

                  (i) Without limiting any other provision hereof, in case the
Issuer after the Closing Date shall do any of the following (each a "Triggering
Event") (a) consolidate with or merge into any other Person and the Issuer shall
not be the continuing or surviving corporation of such consolidation or merger,
or (b) permit any other Person to consolidate with or merge into the Issuer and
the Issuer shall be the continuing or surviving Person but, in connection with
such consolidation or merger, any Capital Stock of the Issuer shall be changed
into or exchanged for securities of any other Person or cash or any other
property, or (c) transfer all or substantially all of its properties or assets
to any other Person, or (d) effect a capital reorganization or reclassification
of its Capital Stock, or (e) enter into any other transaction similar to any of
the foregoing, then, and in the case of each such Triggering Event, proper
provision shall be made so that, upon the basis and the terms and in the manner
provided in this Warrant, the Holder of this Warrant shall be entitled upon the
exercise hereof at any time after the consummation of such Triggering Event, to
the extent this Warrant is not exercised prior to such Triggering Event, or is
not redeemed in connection with such Triggering Event, to receive at the Warrant
Price in effect at the time immediately prior to the consummation of such
Triggering Event, in lieu of the Common Stock issuable upon such

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exercise of this Warrant prior to such Triggering Event, the securities, cash
and property to which such Holder would have been entitled upon the consummation
of such Triggering Event if such Holder had exercised the rights represented by
this Warrant immediately prior thereto, subject to adjustments (subsequent to
such corporate action) as nearly equivalent as possible to the adjustments
provided for in Section 4 hereof. The Issuer shall give reasonable prior notice
(but no less than 5 Business Days' prior notice) of any Triggering Event to the
Holder of this Warrant in accordance with Section 11 hereof.

                  (ii) Notwithstanding anything contained in this Warrant to the
contrary, the Issuer will not effect any Triggering Event unless, prior to the
consummation thereof, each Person (other than the Issuer) which may be required
to deliver any securities, cash or property upon the exercise of this Warrant as
provided herein shall assume, by written instrument delivered to, and reasonably
satisfactory to, the Holder, (a) the obligations of the Issuer under this
Warrant (and if the Issuer shall survive the consummation of such Triggering
Event, such assumption shall be in addition to, and shall not release the Issuer
from, any continuing obligations of the Issuer under this Warrant) and (b) the
obligation to deliver to such Holder such securities, cash or property as, in
accordance with the foregoing provisions of this Section 2(g), such Holder shall
be entitled to receive, and such Person shall have similarly delivered to such
Holder an opinion of counsel for such Person (which may be in-house counsel),
which opinion of counsel shall be reasonably satisfactory to such Holder,
stating that this Warrant shall thereafter continue in full force and effect and
the terms hereof (including, without limitation, all of the provisions of this
Section 2(g)) shall be applicable to the securities, cash or property which such
Person may be required to deliver upon any exercise of this Warrant or the
exercise of any rights pursuant hereto.

      3. Stock Fully Paid; Reservation and Listing of Shares; Covenants.

            (a) The Issuer represents, warrants, covenants and agrees that all
shares of Warrant Stock which may be issued upon the exercise of this Warrant,
will, upon issuance, be duly authorized, validly issued, fully paid and
non-assessable and free from all taxes, liens and charges created by or through
the Issuer with respect to issuance (other than restrictions under federal and
state securities laws). The Issuer further covenants and agrees that during the
period within which this Warrant may be exercised, the Issuer will at all times
have authorized and reserved a sufficient number of shares of Common Stock to
provide for the exercise of this Warrant.

            (b) If any shares of the Common Stock required to be reserved for
issuance upon exercise of this Warrant or as otherwise provided hereunder
require registration or qualification with any governmental authority under any
federal or state law before such shares may be so issued, the Issuer will in
good faith use its best efforts as expeditiously as possible at its expense to
cause such shares to be duly registered or qualified. To the extent permissible
under the applicable securities exchange rules, if the Issuer shall list any
shares of Common Stock on any securities exchange it will, at its expense, list
thereon, maintain and increase when necessary such listing of, all shares of
Warrant Stock from time to time issued upon exercise of this Warrant or as
otherwise provided hereunder and unissued shares of Warrant Stock which are at
any time issuable hereunder, so long as any shares of Common Stock shall be so
listed. The Issuer will also so list on each securities exchange, and will
maintain such listing of, any other

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securities which the Holder of this Warrant shall be entitled to receive upon
the exercise of this Warrant if at the time any securities of the same class
shall be listed on such securities exchange by the Issuer.

            (c) The Issuer shall not by any action including, without
limitation, amending its Certificate of Incorporation or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or
sale of securities or any other action, avoid or seek to avoid the observance or
performance of any of the terms of this Warrant, but will at all times in good
faith assist in the carrying out of all such terms and in the taking of all such
actions as may be necessary or appropriate to protect the rights of the Holder
hereof against impairment. Without limiting the generality of the foregoing,
without the consent of the Requisite Holders, the Issuer will (i) not permit the
par value, if any, of its Common Stock to exceed the then effective Warrant
Price, (ii) not amend or modify any provision of the Certificate of
Incorporation or by-laws of the Issuer in any manner that would adversely affect
in any way the powers, preferences or relative participating, optional or other
special rights of the Holders of the Warrants disproportionately in relation to
the holders of the Common Stock, (iii) take all such action as may be reasonably
necessary in order that the Issuer may validly and legally issue fully paid and
nonassessable shares of Common Stock, free and clear of any liens, claims,
encumbrances and restrictions (other than as provided herein and restrictions
under federal and state securities laws) created by or through Issuer with
respect to such issuance upon the exercise of this Warrant, and (iv) use its
reasonable best efforts to obtain all such authorizations, exemptions or
consents from any public regulatory body having jurisdiction thereof as may be
necessary to enable the Issuer to perform its obligations under this Warrant.

            (d) The Issuer agrees that neither it nor its Affiliates will in the
future issue any press releases or other public disclosure, including any
prospectus, proxy statement or other materials filed with any governmental
authority relating to a public offering of the stock of the Issuer or any of its
Subsidiaries, using the name of the Holder or its Affiliates without at least
two (2) Business Days prior notice to the Holder and without the prior written
consent of the Holder unless (and only to the extent that) the Issuer or its
Affiliate is required to do so under law and then, in any event, the Issuer or
such Affiliate will consult with the Holder before issuing such press release or
other public disclosure.

      4. Adjustment of Warrant Price and Warrant Share Number. The Warrant Share
Number and the Warrant Price shall be subject to adjustment from time to time
upon the happening of certain events, and the Holder hereof shall have
additional rights, as follows:

            (a) Subdivision or Combination of Shares. If the Issuer, at any time
while this Warrant is outstanding, shall subdivide or combine any shares of
Common Stock, (i) in case of subdivision of shares, the Warrant Share Number
shall be proportionately increased (as at the effective date of such
subdivision) to reflect the increase in the total number of shares of Common
Stock outstanding as a result of such subdivision, or (ii) in the case of a
combination of shares, the Warrant Share Number shall be proportionately reduced
(as at the effective date of such combination) to reflect the reduction in the
total number of shares of Common Stock outstanding as a result of such
combination.

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            (b) Certain Dividends and Distributions. If the Issuer, at any time
while this Warrant is outstanding, shall:

                  (i) Stock Dividends. Pay a dividend in, or make any other
distribution to its stockholders (without consideration therefor) of, shares of
Common Stock or any Common Stock Equivalent, the Warrant Share Number shall be
adjusted, as at the date of such payment or other distribution), to that number
determined by multiplying the Warrant Share Number in effect immediately prior
to such payment or other distribution, by a fraction (1) the numerator of which
shall be the total number of shares of Common Stock outstanding immediately
after such dividend or distribution (plus in the event that the Issuer paid cash
for fractional shares, the number of additional shares which would have been
outstanding had the Issuer issued fractional shares in connection with said
dividends), and (2) the denominator of which shall be the total number of shares
of Common Stock outstanding immediately prior to such dividend or distribution;
or

                  (ii) Liquidating Dividends, etc. Make a distribution of its
property to the holders of its Common Stock as a dividend in liquidation or
partial liquidation or by way of return of capital other than as a dividend
payable out of funds legally available for dividends under the laws of the State
of Delaware, the Issuer shall concurrently make a cash payment to the Holder of
this Warrant equal to the fair market value of such property as would have been
payable to such Holder had such Holder been the Holder of record of the number
of shares of Warrant Stock issuable upon exercise of this Warrant on the record
date for such distribution or if no such record is taken, on the date of such
distribution; and appropriate provision therefor shall be made a part of any
such distribution; or

            (c) Other Action Affecting Common Stock. In case after the Closing
Date, the Issuer shall take any action affecting its Common Stock, other than an
action described in any of the foregoing Sections 4(a) through 4(b), inclusive,
and the failure to make any adjustment would not fairly protect the purchase
rights represented by this Warrant in accordance with the essential intent and
principle of this Section 4, then the Warrant Share Number shall be adjusted in
such manner and at such time as the Board may in good faith determine to be
equitable in the circumstances.

            (d) Adjustment of Warrant Price. Upon each adjustment in the Warrant
Share Number pursuant to any of the foregoing provisions of this Section 4, the
Warrant Price shall be adjusted, to the nearest ten thousandth of one cent, to
the product obtained by multiplying the Warrant Price immediately prior to such
adjustment in the Warrant Share Number by a fraction, the numerator of which
shall be the Warrant Share Number immediately before giving effect to such
adjustment and the denominator of which shall be the Warrant Share Number
immediately after giving effect to such adjustment; provided, however, that if
at any time, as a result of any adjustments hereunder, the Warrant Price shall
be less than the par value per share of Warrant Stock, then the price payable
per share of Warrant Stock by the Holder hereunder in the event of an exercise
of this Warrant at such time in whole or in part shall be an amount equal to the
par value per share of such Warrant Stock.

      5. Notice of Adjustments. Whenever the Warrant Price or Warrant Share
Number shall be adjusted pursuant to Section 4 hereof (for purposes of this
Section 5, an

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"adjustment"), the Issuer shall cause its Chief Financial Officer to prepare and
execute a certificate setting forth, in reasonable detail, the event requiring
the adjustment, the amount of the adjustment, the method by which such
adjustment was calculated (including a description of the basis on which the
Board made any determination hereunder), and the Warrant Price and Warrant Share
Number after giving effect to such adjustment, and shall cause copies of such
certificate to be delivered to the Holder of this Warrant promptly after each
adjustment. Any dispute between the Issuer and the Holder of this Warrant with
respect to the matters set forth in such certificate may at the option of the
Requisite Holders of this Warrant be submitted to an independent accounting firm
not then regularly engaged by the Issuer chosen by the Issuer and reasonably
acceptable to the Requisite Holders, which firm shall deliver a written opinion
as to such matters to the Issuer and the Holders within thirty days after
submission to it of such dispute. Such opinion shall be final and binding on the
parties hereto. The fees and expenses of such accounting firm shall be paid by
the Issuer.

      6. Fractional Shares. No fractional shares of Warrant Stock will be issued
in connection with any exercise hereof, but in lieu of such fractional shares,
the Issuer shall make a cash payment therefor equal in amount to the fair market
value of such fractional shares.

      7. Definitions. For the purposes of this Warrant, the following terms have
the following meanings:

      "Affiliate" means, with respect to any Person, (a) each Person that,
directly or indirectly, owns or controls, whether beneficially, or as a trustee,
guardian or other fiduciary, 5% or more of the Voting Stock of such Person, (b)
each Person that controls, is controlled by or is under common control with such
Person, (c) each of such Person's officers, directors, joint venturers and
partners and (d) in the case of the Issuer, the immediate family members,
spouses and lineal descendants of individuals who are Affiliates of the Issuer.
For the purposes of this definition, "control" of a Person shall mean the
possession, directly or indirectly, of the power to direct or cause the
direction of its management or policies, whether through the ownership of voting
securities, by contract or otherwise.

      "Board" shall mean the Board of Directors of the Issuer.

      "Business Day" means any day except a Saturday, a Sunday or a legal
holiday in New York City.

      "Capital Stock" means and includes (i) any and all shares, interests,
participations or other equivalents of or interests in (however designated)
corporate stock, including, without limitation, shares of preferred or
preference stock, (ii) all partnership interests (whether general or limited) in
any Person which is a partnership, (iii) all membership interests or limited
liability company interests in any limited liability company, and (iv) all
equity or ownership interests in any Person of any other type.

      "Certificate of Incorporation" means the Certificate of Incorporation of
the Issuer as in effect on the Closing Date, and as hereafter from time to time
amended, modified, supplemented or restated in accordance with its terms and
pursuant to applicable law.

      "Closing Date" means March 24, 2006.

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      "Common Stock" means the Common Stock of the Issuer, par value $.001 per
share, and any other Capital Stock into which such stock may hereafter be
changed.

      "Credit Agreement" means that certain credit agreement, dated as of the
Closing Date by and among the Issuer, the Investor and the other borrowers and
lenders party thereto.

      "Current Market Price" as in effect on any day, means the average of the
daily market prices of the Common Stock on the the Nasdaq Stock Markets National
Market System ("NMS") for the period of 30 consecutive trading days ending three
trading days preceding such date or, if the Common Stock is not listed on the
NMS, then the last sale price on such day on the principal domestic stock
exchange on which such Common Stock is then listed or admitted to trading, or,
if no sale takes place on such day on such exchange, the average of the closing
bid and asked prices on such day as officially quoted on such exchange, or, if
the Common Stock is not then listed or admitted to trading on any domestic stock
exchange, then the Current Market Price for each such trading day shall be the
average of the reported closing bid and asked price quotations on such day in
the over-the-counter market, as reported by NASDAQ, or, if not so reported, as
furnished by the National Quotation Bureau, Inc., or if such firm at the time is
not engaged in the business of reporting such prices, as furnished by any
similar firm then engaged in such business as selected by the Issuer, or if
there is no such firm, as furnished by any member of the National Association of
Securities Dealers, Inc. selected by the Issuer with the written approval of the
Requisite Holders (which approval shall not be unreasonably withheld). If at any
time such Common Stock is not listed on any domestic exchange or quoted in the
domestic over-the-counter market, the Current Market Price shall be deemed to be
the fair market value per share of such Common Stock as determined in good faith
by the Board (by determination of its disinterested members) by notice to the
Holder. If within twenty days after receipt of such notice the Holder notifies
the Board in writing to its disagreement as to such fair market value as
determined by the Board, the Current Market Price shall be the fair market value
per share of such Common Stock as determined by an Independent Appraiser
mutually selected by the Issuer and the Holder, which selection shall be made by
the Issuer and the Holder within seven days of receipt of such objection by the
Issuer. The determination of fair market value by such Independent Appraiser
shall be made within 30 days of such appraiser's engagement by Issuer. The fees
and expenses of such Independent Appraiser shall be paid by the Issuer if such
fair market value as so determined is more than 5% greater (if the Holder's
objection was that such determination was too low) or 5% lower (if the Requisite
Holder's objection was that such determination was too high), in each case, than
the amount thereof as determined by the Board, but shall otherwise be paid by
the Holder. The determination of fair market value by such Independent Appraiser
shall be based upon the fair market value of the Issuer determined on a going
concern basis as between a willing buyer and a willing seller and taking into
account all relevant factors determinative of value (but without taking into
account any discount for minority or non-control ownership positions), and shall
be final and binding on all parties. In determining the fair market value of any
shares of Common Stock, no consideration shall be given to any restrictions on
transfer of the Common Stock imposed by agreement or by federal or state
securities laws, or to the existence or absence of, or any limitations on,
voting rights, or to minority or non-control ownership positions.

      "Exchange Act" means the Securities Exchange Act of 1934, as amended, or
any similar federal statute at the time in effect.

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      "Holders" mean the Persons who shall from time to time own any Warrant.
The term "Holder" means one of the Holders.

      "Independent Appraiser" means a nationally recognized investment banking
firm or other nationally recognized firm, in each case, that is regularly
engaged in the business of appraising the Capital Stock or assets of
corporations or other entities as going concerns, and which is not affiliated
with either the Issuer or the Holder.

      "Issuer" has the meaning specified in the first paragraph hereof.

      "Person" means an individual, a corporation, a partnership, a trust, a
limited liability company, an unincorporated organization or a government
organization or an agency or political subdivision thereof.

      "Requisite Holders" means at any time the Holders of Warrants (other than
the Issuer or any Subsidiary thereof) exercisable for a majority of the shares
of Warrant Stock issuable under the Warrants at the time outstanding.

      "Securities" means any debt or equity securities of the Issuer, whether
now or hereafter authorized, any instrument convertible into or exchangeable for
Securities or a Security, and any option, warrant or other right to purchase or
acquire any Security. "Security" means one of the Securities.

      "Securities Act" means the Securities Act of 1933, as amended, or any
similar federal statute then in effect.

      "Subsidiary" means any corporation at least 50% of whose outstanding
Voting Stock shall at the time be owned directly or indirectly by the Issuer or
by one or more of its Subsidiaries, or by the Issuer and one or more of its
Subsidiaries.

      "Voting Stock", any class or classes (however designated) of capital stock
having ordinary voting power for the election of a majority of the members of
the Board (or other governing body) of the corporation, other than Capital Stock
having such power only by reason of the happening of a contingency.

      "Warrants" means this Warrant and any other warrants of like tenor issued
in substitution or exchange for any thereof pursuant to the provisions of
Section 2(c) or 2(d) hereof or of any of such other Warrants.

      "Warrant Price" means the exercise price per share of Common Stock
specified in the first paragraph of this Warrant and such other exercise prices
as shall result from the adjustments specified in Section 4 hereof.

      "Warrant Share Number" means at any time the aggregate number of shares of
Warrant Stock which may at such time be purchased upon exercise of this Warrant,
after giving effect to all prior adjustments to such number made or required to
be made under the terms hereof.

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      "Warrant Stock" means Common Stock issuable upon exercise of any Warrant
or Warrants or otherwise issuable pursuant to any Warrant or Warrants.

      8. Information. The Issuer shall deliver to the Holder hereof a copy of
the Issuer's annual report and any other information mailed to stockholders as
if the Holder were a stockholder.

      9. Amendment and Waiver. Any term, covenant, agreement or condition in
this Warrant may be amended, or compliance therewith may be waived (either
generally or in a particular instance and either retroactively or
prospectively), by a written instrument or written instruments executed by the
Issuer and the Requisite Holders; provided, however, that no such amendment or
waiver shall reduce the Warrant Share Number, increase the Warrant Price,
shorten the period during which this Warrant may be exercised, change the manner
of payment of the Warrant Price or modify any provision of this Section 9
without the consent of the Holder of this Warrant.

      10. Governing Law. THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT GIVING EFFECT TO
CONFLICTS OF LAW PRINCIPLES THEREOF.

      11. Notices. All notices and other communications provided for hereunder
shall be in writing and delivered by hand or sent by first class registered
mail, return receipt requested, or sent by telecopy (with such telecopy to be
confirmed promptly in writing sent by first class registered mail, return
receipt requested), and if to the Holder of this Warrant or of Warrant Stock
issued pursuant hereto, addressed to such Holder at its last known address or
telecopy number appearing on the books of the Issuer maintained for such
purposes, and if to the Issuer, addressed to:

                            Zila, Inc.
                            5227 North 7th Street
                            Phoenix, AZ 85014-2800

or to such other address or addresses or telecopy number or numbers as any such
party may most recently have designated in writing to the other parties hereto
by such notice. All such communications shall be deemed to have been given or
made when so delivered by hand, upon actual receipt if sent by telecopy, or
three business days after being so mailed.

      12. Remedies. The Issuer stipulates that the remedies at law of the Holder
of this Warrant in the event of any default or threatened default by the Issuer
in the performance of or compliance with any of the terms of this Warrant are
not and will not be adequate and that, to the fullest extent permitted by law,
such terms may be specifically enforced by a decree for the specific performance
of any agreement contained herein or by an injunction against a violation of any
of the terms hereof or otherwise. Time is of the essence in this Warrant.

      13. Successors and Assigns. This Warrant and the rights evidenced hereby
shall inure to the benefit of and be binding upon the successors and assigns of
the Issuer, the Holder hereof and (to the extent provided herein) the Holders of
Warrant Stock issued pursuant hereto, and shall be enforceable by any such
Holder or Holder of Warrant Stock.

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      14. No Voting Rights. This Warrant does not confer upon the Holder any
right to vote on, consent to or otherwise participate with respect to matters to
a vote of the stockholders of the Issuer or to receive notice as a stockholder
of the Issuer, as such, in respect of any matters whatsoever, nor any other
rights or liabilities as a stockholder, prior to the exercise hereof; this
Warrant does, however, require certain notices to the Holder as set forth
herein.

      15. Modification and Severability. If, in any action before any court or
agency legally empowered to enforce any provision contained herein, any
provision hereof is found to be unenforceable, then such provision shall be
deemed modified to the extent necessary to make it enforceable by such court or
agency. If any such provision is not enforceable as set forth in the preceding
sentence, the unenforceability of such provision shall not affect the other
provisions of this Warrant, but this Warrant shall be construed as if such
unenforceable provision had never been contained herein.

      16. Integration. This Warrant replaces all prior agreements, supersedes
all prior negotiations and constitutes the entire agreement of the parties with
respect to the transactions contemplated herein.

      17. Headings. The headings of the Sections of this Warrant are for
convenience of reference only and shall not, for any purpose, be deemed a part
of this Warrant.

                            [SIGNATURE PAGE FOLLOWS]

                                       11
<PAGE>

      In witness whereof, this Warrant has been duly executed as of the date of
this Warrant hereinabove set forth.

                                       ZILA, INC.

                                       By: /s/ Andrew A. Stevens
                                           ------------------------------------
                                       Name:  Andrew A. Stevens
                                       Title:  VP & CFO

                                       12
<PAGE>

                                  EXERCISE FORM

[    ]

      The undersigned hereby irrevocably elects to exercise the right to
purchase represented by the attached Warrant for, and to purchase thereunder,___
shares of Common Stock, par value $.001 per share (the "COMMON STOCK"), of Zila,
Inc. (the "ISSUER"), as provided for therein, and tenders herewith payment of
the Warrant Price in full in accordance with the terms of the attached Warrant.

      Please issue a certificate or certificates for such shares of Common Stock
in the following name or names and denominations:

      If said number of shares of Common Stock shall not be all the shares of
Common Stock issuable upon exercise of the attached Warrant, a new Warrant is to
be issued in the name of the undersigned for the balance remaining of such
shares of Common Stock less any fraction of a share of Common Stock paid in
cash.

Dated:  _____________                  Signature  ________________________
                                       Address    ________________________
                                                  ________________________

                                       13
<PAGE>

                                   ASSIGNMENT

FOR VALUE RECEIVED, the undersigned registered owner of this Warrant hereby
sells, assigns and transfers unto _______________ the within Warrant and all
rights evidenced thereby and does irrevocably constitute and appoint
_______________, attorney, to transfer the said Warrant on the books of the
within named corporation.

Dated:  _____________                  Signature  ________________________
                                       Address    ________________________
                                                  ________________________

                               PARTIAL ASSIGNMENT

FOR VALUE RECEIVED, the undersigned registered owner of this Warrant hereby
sells, assigns and transfers unto _________________ the right to purchase
________ shares of the Common Stock issuable upon exercise of the attached
Warrant, and does irrevocably constitute and appoint __________________,
attorney, to transfer that part of the said Warrant on the books of the within
named corporation.

Dated:  _____________                  Signature  ________________________
                                       Address    ________________________
                                                  ________________________

FOR USE BY THE ISSUER ONLY:

This Warrant No. W-_ cancelled (or transferred or exchanged) this ___ day of
__________, 20_, shares of Common Stock issued therefor in the name of
___________________, Warrant No. W-____ issued for _____ shares of Common Stock
in the name of_______________________

                                       14<PAGE>

                                                                    Exhibit 10.1

--------------------------------------------------------------------------------

                                   $40,000,000

                                CREDIT AGREEMENT

                                      among

                                   ZILA, INC.,
                              ZILA TECHNICAL, INC.,
                            ZILA BIOTECHNOLOGY, INC.,
                           ZILA NUTRACEUTICALS, INC.,
                         ZILA PHARMACEUTICALS, INC. and
                          ZILA SWAB TECHNOLOGIES, INC.

                                  as Borrowers,

                               The Several Lenders
                        from Time to Time Parties Hereto,

                                       and

                    BLACK DIAMOND COMMERCIAL FINANCE, L.L.C.,
                             as Administrative Agent

                           Dated as of March 24, 2006

--------------------------------------------------------------------------------

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                                              PAGE
<S>                                                                                                           <C>
SECTION 1.        DEFINITIONS...............................................................................    1

     1.1      Defined Terms.................................................................................    1
     1.2      Other Definitional Provisions.................................................................   16

SECTION 2.        AMOUNT AND TERMS OF TERM LOAN COMMITMENTS AND WARRANTS....................................   17

     2.1      Term Loan.....................................................................................   17
     2.2      Repayment of Term Loan........................................................................   17
     2.3      Warrants......................................................................................   17

SECTION 3.        TACK-ON TERM LOAN.........................................................................   17

     3.1      Tack-On Term Loan.............................................................................   17

SECTION 4.        GENERAL PROVISIONS APPLICABLE TO THE TERM LOAN............................................   18

     4.1      Optional Prepayments..........................................................................   18
     4.2      Mandatory Prepayments and Commitment Reductions...............................................   18
     4.3      Make-Whole....................................................................................   19
     4.4      Interest Rates and Default Rate of Interest...................................................   19
     4.5      Computation of Interest and Fees..............................................................   19
     4.6      Pro Rata Treatment and Payments...............................................................   19
     4.7      Requirements of Law...........................................................................   20
     4.8      Taxes.........................................................................................   21
     4.9      Change of Lending Office......................................................................   23
     4.10     Replacement of Lenders........................................................................   23
     4.11     Evidence of Debt..............................................................................   24

SECTION 5.        REPRESENTATIONS AND WARRANTIES............................................................   24

     5.1      Financial Condition...........................................................................   24
     5.2      No Change.....................................................................................   25
     5.3      Corporate Existence; Compliance with Law......................................................   25
     5.4      Power; Authorization; Enforceable Obligations.................................................   25
     5.5      No Legal Bar..................................................................................   26
     5.6      Litigation....................................................................................   26
     5.7      No Default....................................................................................   26
     5.8      Ownership of Property; Liens..................................................................   26
     5.9      Intellectual Property.........................................................................   26
     5.10     Taxes.........................................................................................   27
     5.11     Federal Regulations...........................................................................   27
     5.12     Labor Matters.................................................................................   27
     5.13     ERISA.........................................................................................   27
     5.14     Investment Company Act; Other Regulations.....................................................   28
     5.15     Subsidiaries..................................................................................   28
     5.16     Use of Proceeds...............................................................................   28
     5.17     Environmental Matters.........................................................................   28
</TABLE>

                                       -i-

<PAGE>

                                TABLE OF CONTENTS
                                   (continued)

<TABLE>
<CAPTION>
                                                                                                              PAGE
<S>                                                                                                           <C>
     5.18     Accuracy of Information, etc. ................................................................   29
     5.19     Security Documents............................................................................   30
     5.20     Deposit Accounts..............................................................................   30
     5.21     Solvency......................................................................................   30
     5.22     Foreign Assets Control Regulations............................................................   30
     5.23     Anti-Terrorism Laws...........................................................................   31
     5.24     Regulation H..................................................................................   31

SECTION 6.        CONDITIONS PRECEDENT......................................................................   32

     6.1      Conditions to Extension of Term Loan..........................................................   32
     6.2      Conditions to Extension of Tack-On Term Loan..................................................   34

SECTION 7.        AFFIRMATIVE COVENANTS.....................................................................   35

     7.1      Financial Statements..........................................................................   35
     7.2      Certificates; Other Information...............................................................   36
     7.3      Payment of Obligations........................................................................   37
     7.4      Maintenance of Existence; Compliance..........................................................   37
     7.5      Maintenance of Property; Insurance............................................................   37
     7.6      Inspection of Property; Books and Records; Discussions........................................   37
     7.7      Notices.......................................................................................   38
     7.8      Environmental Laws............................................................................   38
     7.9      Additional Collateral, etc. ..................................................................   39
     7.10     Patriot Act Compliance........................................................................   40
     7.11     Payment of Fees and Expenses..................................................................   40
     7.12     Landlord Waivers; Bailee Letters..............................................................   40
     7.13     Cash Management Systems.......................................................................   40
     7.14     Further Assurances............................................................................   40
     7.15     Certain Subsidiaries..........................................................................   41
     7.16     Salaries......................................................................................   41
     7.17     Mortgages, etc. ..............................................................................   41

SECTION 8.        NEGATIVE COVENANTS........................................................................   43

     8.1      Financial Condition Covenants.................................................................   43
     8.2      Indebtedness..................................................................................   47
     8.3      Liens.........................................................................................   47
     8.4      Fundamental Changes...........................................................................   48
     8.5      Disposition of Property.......................................................................   49
     8.6      Restricted Payments...........................................................................   49
     8.7      Capital Expenditures..........................................................................   49
     8.8      Investments...................................................................................   49
     8.9      Optional Payments and Modifications of Certain Debt Instruments...............................   50
     8.10     Transactions with Affiliates..................................................................   50
     8.11     Sales and Leasebacks..........................................................................   50
</TABLE>

                                      -ii-

<PAGE>

                                TABLE OF CONTENTS
                                   (continued)

<TABLE>
<CAPTION>
                                                                                                              PAGE
<S>                                                                                                           <C>
     8.12     Hedge Agreements..............................................................................   50
     8.13     Changes in Fiscal Periods.....................................................................   50
     8.14     Negative Pledge Clauses.......................................................................   50
     8.15     Clauses Restricting Subsidiary Distributions..................................................   51
     8.16     Lines of Business.............................................................................   51
     8.17     Cancellation of Indebtedness..................................................................   51
     8.18     Additional Deposit Accounts...................................................................   51
     8.19     Amendments to Material Contracts..............................................................   51
     8.20     Holdings......................................................................................   51
     8.21     Accounts......................................................................................   52
     8.22     UBS Account...................................................................................   52

SECTION 9.        EVENTS OF DEFAULT.........................................................................   52

SECTION 10.       THE ADMINISTRATIVE AGENT..................................................................   55

     10.1     Appointment...................................................................................   55
     10.2     Delegation of Duties..........................................................................   55
     10.3     Exculpatory Provisions........................................................................   55
     10.4     Reliance by Administrative Agent..............................................................   56
     10.5     Notice of Default.............................................................................   56
     10.6     Non-Reliance on the Administrative Agent and Other Lenders....................................   56
     10.7     Indemnification...............................................................................   57
     10.8     The Administrative Agent in Its Individual Capacity...........................................   57
     10.9     Successor Administrative Agent................................................................   58
     10.10    Agents Generally..............................................................................   58

SECTION 11.       MISCELLANEOUS.............................................................................   58

     11.1     Amendments and Waivers........................................................................   58
     11.2     Notices.......................................................................................   59
     11.3     No Waiver; Cumulative Remedies................................................................   60
     11.4     Survival of Representations and Warranties....................................................   60
     11.5     Payment of Expenses and Taxes.................................................................   60
     11.6     Successors and Assigns; Participations and Assignments........................................   61
     11.7     Adjustments; Set-off..........................................................................   65
     11.8     Counterparts..................................................................................   65
     11.9     Severability..................................................................................   65
     11.10    Integration...................................................................................   66
     11.11    GOVERNING LAW.................................................................................   66
     11.12    Submission To Jurisdiction; Waivers...........................................................   66
     11.13    Acknowledgments...............................................................................   66
     11.14    Releases of Guarantees and Liens..............................................................   67
     11.15    Confidentiality...............................................................................   67
     11.16    WAIVERS OF JURY TRIAL.........................................................................   67
</TABLE>

                                      -iii-

<PAGE>

SCHEDULES:

1.1               Real Property
5.4               Consents, Authorizations, Filings and Notices
5.15              Subsidiaries
5.15(a)           Outstanding Options and Warrants
5.19(a)           UCC Filing Jurisdictions
5.19(b)           Mortgage Filing Jurisdictions
5.20              Deposit Accounts
8.2(d)            Existing Indebtedness
8.3(f)            Existing Liens
8.20              Material Contracts

EXHIBITS:

A                 Form of Assignment and Assumption
B                 Form of Compliance Certificate
C                 Form of Guarantee and Collateral Agreement
D                 Form of Exemption Certificate
E                 Form of Term Note
F                 Form of Closing Certificate
G                 Form of Warrant
H                 Form of Registration Rights Agreement

<PAGE>

            CREDIT AGREEMENT, dated as of March 24, 2006, is by and among ZILA,
INC., a Delaware corporation ("Holdings"), ZILA NUTRACEUTICALS, INC. (formerly
known as Oxycal Laboratories Incorporated), an Arizona corporation, ZILA
TECHNICAL, INC., an Arizona corporation, ZILA BIOTECHNOLOGY, INC., an Arizona
corporation, ZILA PHARMACEUTICALS, INC., a Nevada corporation, and ZILA SWAB
TECHNOLOGIES, INC., an Arizona corporation (each entity, together with Holdings,
shall be collectively referred to herein as the "Borrowers"), the several banks
and other financial institutions or entities from time to time parties to this
Agreement (the "Lenders"), and BLACK DIAMOND COMMERCIAL FINANCE, L.L.C., a
Delaware limited liability company, as administrative agent (in such capacity,
the "Administrative Agent").

                                    RECITALS

            WHEREAS, the Borrowers desire to obtain the Loans from the Lenders
and the Lenders are willing to provide the Loans in accordance with the terms of
this Agreement; and

            WHEREAS, the Borrowers have agreed to issue to the Initial Term
Lender Warrants to purchase an aggregate of up to 1,200,000 shares of its Common
Stock (subject to adjustment as therein provided) upon the terms and conditions
hereinafter provided; and

            NOW, THEREFORE, in consideration of the premises and the mutual
covenants hereinafter contained, the parties hereto agree as follows:

                                   SECTION 1.

                                   DEFINITIONS

            1.1 Defined Terms. As used in this Agreement, the terms listed in
this Section 1.1 shall have the respective meanings set forth in this Section
1.1.

            "ALTA": the American Land Title Association.

            "Account Debtor": any Person who may become obligated to any
Borrower under, with respect to, or on account of, an Account, chattel paper or
general intangibles (including a payment intangible).

            "Accounts": all "accounts," as such term is defined in the Uniform
Commercial Code, now owned or hereafter acquired by any Borrower, including (a)
all accounts receivable, other receivables, book debts and other forms of
obligations (other than forms of obligations evidenced by chattel paper, or
instruments) (including any such obligations that may be characterized as an
account or contract right under the Uniform Commercial Code), (b) all of each
Borrower's rights in, to and under all purchase orders or receipts for goods or
services, (c) all of each Borrower's rights to any goods represented by any of
the foregoing (including unpaid sellers' rights of rescission, replevin,
reclamation and stoppage in transit and rights to returned, reclaimed or
repossessed goods), (d) all rights to payment due to any Borrower for property
sold, leased, licensed, assigned or otherwise disposed of, for a policy of
insurance issued or to be issued, for a secondary obligation incurred or to be
incurred, for energy provided or to be provided, for the use or hire of a vessel
under a charter or other contract, arising out of

<PAGE>

the use of a credit card or charge card, or for services rendered or to be
rendered by such Borrower or in connection with any other transaction (whether
or not yet earned by performance on the part of such Borrower), (e) all health
care insurance receivables and (f) all collateral security, guarantees and other
Supporting Obligations of any kind, given by any Account Debtor or any other
Person with respect to any of the foregoing.

            "Administrative Agent": as defined in the recitals to this
Agreement.

            "Affiliate": as to any Person, any other Person that, directly or
indirectly, is in control of, is controlled by, or is under common control with,
such Person. For purposes of this definition, "control" of a Person means the
power, directly or indirectly, either to (a) vote 10% or more of the securities
having ordinary voting power for the election of directors (or persons
performing similar functions) of such Person or (b) direct or cause the
direction of the management and policies of such Person, whether by contract or
otherwise.

            "Aggregate Exposure": with respect to any Lender at any time, an
amount equal to (a) until the Closing Date, the aggregate amount of such
Lender's Commitments at such time and (b) thereafter, the sum of the aggregate
then unpaid principal amount of such Lender's Loans.

            "Aggregate Exposure Percentage": with respect to any Lender at any
time, the ratio (expressed as a percentage) of such Lender's Aggregate Exposure
at such time to the Aggregate Exposure of all Lenders at such time.

            "Agreement": this Credit Agreement, as amended, restated,
supplemented and otherwise modified from time to time in accordance with the
provisions hereof.

            "Anti-Terrorism Laws": as defined in Section 5.23(a).

            "Applicable Margin": for the Term Loan, the rate per annum set forth
under the relevant column heading below:

<TABLE>
<CAPTION>
              Time Frame                          Cash Interest     PIK Interest
              ----------                          -------------     ------------
<S>                                               <C>               <C>
From and after the Closing Date through
September 30, 2006                                    10.00%            4.00%

from September 30, 2006 through March 31,
2007                                                  10.00%            5.00%

from March 31, 2007 through September 30,
2007                                                  10.00%            6.00%

from September 30, 2007 through March 31,
2008                                                  10.00%            6.00%
</TABLE>

            "Approved Fund": as defined in Section 11.6(c).

                                        2
<PAGE>

            "Asset Sale": any Disposition of Property or series of related
Dispositions of Property (excluding any such Disposition permitted by clause
(b), (c) or (d) of Section 8.5) that yields gross proceeds to any Group Member
(valued at the initial principal amount thereof in the case of non-cash proceeds
consisting of notes or other debt securities and valued at fair market value in
the case of other non-cash proceeds) in excess of $100,000 per Disposition (in
any single transaction or series of transactions) or $250,000 the aggregate.

            "Assignee": as defined in Section 11.6(b).

            "Assignment and Assumption": an Assignment and Assumption,
substantially in the form of Exhibit A.

            "Benefited Lender": as defined in Section 11.7(a).

            "Bio/Pharma Operations": collectively, the businesses operated by
Zila Technical, Inc. Zila Biotechnology, Inc., Zila Pharmaceuticals, Inc. and
Zila Swab Technologies, Inc.

            "Board": the Board of Governors of the Federal Reserve System of the
United States (or any successor).

            "Borrower Representative": Holdings.

            "Borrowers": as defined in the preamble to this Agreement.

            "Business": as defined in Section 5.17(b).

            "Business Day": a day other than a Saturday, Sunday or other day on
which commercial banks in New York City are authorized or required by law to
close.

            "Capital Expenditures": for any period, with respect to any Person,
the aggregate of all expenditures by such Person and its Subsidiaries for the
acquisition or leasing (pursuant to a capital lease) of fixed or capital assets
or additions to equipment (including replacements, capitalized repairs and
improvements during such period) that should be capitalized under GAAP on a
consolidated balance sheet of such Person and its Subsidiaries.

            "Capital Lease Obligations": as to any Person, the obligations of
such Person to pay rent or other amounts under any lease of (or other
arrangement conveying the right to use) real or personal property, or a
combination thereof, which obligations are required to be classified and
accounted for as capital leases on a balance sheet of such Person under GAAP
and, for the purposes of this Agreement, the amount of such obligations at any
time shall be the capitalized amount thereof at such time determined in
accordance with GAAP.

            "Capital Stock": any and all shares, interests, participations or
other equivalents (however designated) of capital stock of a corporation,
including preferred stock, any and all equivalent ownership interests in a
Person (other than a corporation) and any and all warrants, rights or options to
purchase any of the foregoing.

                                        3
<PAGE>

            "Cash Equivalents": (a) marketable direct obligations issued by, or
unconditionally guaranteed by, the United States Government or issued by any
agency thereof and backed by the full faith and credit of the United States, in
each case maturing within one year from the date of acquisition; (b)
certificates of deposit, time deposits, eurodollar time deposits or overnight
bank deposits having maturities of six months or less from the date of
acquisition issued by any Lender or by any commercial bank organized under the
laws of the United States or any state thereof having combined capital and
surplus of not less than $500,000,000; (c) commercial paper of an issuer rated
at least A-1 by Standard & Poor's Ratings Services ("S&P") or P-1 by Moody's
Investors Service, Inc. ("Moody's"), or carrying an equivalent rating by a
nationally recognized rating agency, if both of the two named rating agencies
cease publishing ratings of commercial paper issuers generally, and maturing
within six months from the date of acquisition; (d) repurchase obligations of
any Lender or of any commercial bank satisfying the requirements of clause (b)
of this definition, having a term of not more than 30 days, with respect to
securities issued or fully guaranteed or insured by the United States
government; (e) securities with maturities of one year or less from the date of
acquisition issued or fully guaranteed by any state, commonwealth or territory
of the United States, by any political subdivision or taxing authority of any
such state, commonwealth or territory or by any foreign government, the
securities of which state, commonwealth, territory, political subdivision,
taxing authority or foreign government (as the case may be) are rated at least A
by S&P or A by Moody's; (f) securities with maturities of six months or less
from the date of acquisition backed by standby letters of credit issued by any
Lender or any commercial bank satisfying the requirements of clause (b) of this
definition; or (g) shares of money market mutual or similar funds which invest
exclusively in assets satisfying the requirements of clauses (a) through (f) of
this definition or money market funds that (i) comply with the criteria set
forth in Securities and Exchange Commission Rule 2a-7 under the Investment
Company Act of 1940, as amended, (ii) are rated AAA by S&P and Aaa by Moody's
and (iii) have portfolio assets of at least $5,000,000,000.

            "Change of Control": any of the following: (a) any person or group
of persons (within the meaning of the Securities Exchange Act of 1934) shall
have acquired beneficial ownership (within the meaning of Rule 13d-3 promulgated
by the Securities and Exchange Commission under the Securities Exchange Act of
1934) of 20% or more of the issued and outstanding shares of Capital Stock of
Holdings having the right to vote for the election of directors of Holdings
under ordinary circumstances; (b) during any period of twelve consecutive
calendar months, individuals who at the beginning of such period constituted the
board of directors of Holdings (together with any new directors whose election
by the board of directors of Holdings or whose nomination for election by the
Stockholders of Holdings was approved by a vote of at least two-thirds of the
directors then still in office who either were directors at the beginning of
such period or whose election or nomination for election was previously so
approved) cease for any reason other than death or disability to constitute a
majority of the directors then in office; or (c) Holdings ceases to own and
control all of the economic and voting rights associated with all of the
outstanding Capital Stock of any of its Subsidiaries except in connection with a
transaction permitted hereunder.

            "Closing Date": the date on which the conditions precedent set forth
in Section 6.1 shall have been satisfied, which date is March 24, 2006.

                                       4
<PAGE>

            "Code": the Internal Revenue Code of 1986, as amended from time to
time.

            "Collateral": all property of the Loan Parties, now owned or
hereafter acquired, upon which a Lien is purported to be created by any Security
Document.

            "Commitment": as to any Lender, the sum of the Term Loan Commitment
and the Tack-On Term Loan Commitment, if any, of such Lender.

            "Common Stock": the voting common stock, $0.001 par value, of
Holdings.

            "Commonly Controlled Entity": an entity, whether or not
incorporated, that is under common control with the Borrowers within the meaning
of Section 4001 of ERISA or is part of a group that includes the Borrowers and
that is treated as a single employer under Section 414 of the Code.

            "Compliance Certificate": a certificate duly executed by a
Responsible Officer substantially in the form of Exhibit B.

            "Concentration Account": account number 4168592616 in the name of
Holdings at Wells Fargo Bank, N.A., located at Phoenix, Arizona, ABA No.
121000248, which account is subject to the control of the Administrative Agent
pursuant to the Control Agreements or such other account as may be specified in
writing by the Administrative Agent.

            "Conduit Lender": any special purpose entity organized and
administered by any Lender for the purpose of making Loans otherwise required to
be made by such Lender and designated by such Lender in a written instrument,
subject to the consent of the Administrative Agent and the Borrowers (which
consent shall not be unreasonably withheld); provided, that the designation by
any Lender of a Conduit Lender shall not relieve the designating Lender of any
of its obligations to fund a Loan under this Agreement if, for any reason, its
Conduit Lender fails to fund any such Loan, and the designating Lender (and not
the Conduit Lender) shall have the sole right and responsibility to deliver all
consents and waivers required or requested under this Agreement with respect to
its Conduit Lender, and provided, further, that no Conduit Lender shall (a) be
entitled to receive any greater amount pursuant to Section 4.7, 4.8 or 11.5 than
the designating Lender would have been entitled to receive in respect of the
extensions of credit made by such Conduit Lender or (b) be deemed to have any
Commitment.

            "Consolidated Net Income": (i) for the purposes of calculating
compliance with the covenant set forth in Section 8.1(a) with respect to the
Nutraceuticals Business individually, for any period, an amount equal to the
consolidated net income (or loss) attributable to the Nutraceuticals Business
determined in accordance with GAAP; and (ii) for the purposes of calculating
compliance with the covenant set forth in Section 8.1(b) with respect to the
Borrowers and their respective Subsidiaries as a whole, for any period, the
consolidated net income (or loss) of the Borrowers and their respective
Subsidiaries determined on a consolidated basis in accordance with GAAP;
provided that with respect to clause (ii): there shall be excluded (a) the
income (or deficit) of any Person accrued prior to the date it becomes a
Subsidiary of any Borrower or is merged into or consolidated with any Borrower
or any Subsidiary, (b) the income (or deficit) of any Person (other than a
Subsidiary of any Borrower) in which any Borrower or any Subsidiary has an
ownership interest, except to the extent that any such income is actually

                                       5
<PAGE>

received by such Borrower or such Subsidiary in the form of dividends or similar
distributions, (c) income received by such Person attributable to an Asset Sale
and (d) the undistributed earnings of any Subsidiary of any Borrower to the
extent that the declaration or payment of dividends or similar distributions by
such Subsidiary is not at the time permitted by the terms of any Contractual
Obligation (other than under any Loan Document) or Requirement of Law applicable
to such Subsidiary.

            "Contractual Obligation": as to any Person, any provision of any
security issued by such Person or of any agreement, instrument or other
undertaking to which such Person is a party or by which it or any of its
property is bound.

            "Control Agreements": collectively, each tri-party blocked account
agreement by and among the Administrative Agent, the applicable Borrower, and
each bank which maintains an account of such Borrower listed on Schedule 5.20(a)
(other than Excluded Accounts), in form and substance reasonably acceptable to
Administrative Agent.

            "Default": any condition or event that with notice, passage of time,
or both would, if not cured within the time periods (if any) permitted pursuant
to the Loan Documents, be an Event of Default.

            "Disposition": with respect to any Property, any sale, lease, sale
and leaseback, assignment, conveyance, transfer or other disposition thereof.
The terms "Dispose" and "Disposed of" shall have correlative meanings.

            "Dollars" and "$": dollars in lawful currency of the United States.

            "Domestic Subsidiary": any Subsidiary of Holdings organized under
the laws of any jurisdiction within the United States.

            "EBITDA": for any period and for any Person, Consolidated Net Income
for such period plus, without duplication and to the extent reflected as a
charge in the statement of such Consolidated Net Income for such period, the sum
of (a) income tax expense, (b) interest expense, amortization or writeoff of
debt discount and debt issuance costs and commissions, discounts and other fees
and charges associated with Indebtedness (including the Loans), (c) depreciation
and amortization expense, (d) amortization of intangibles (including, but not
limited to, goodwill) and organization costs, (e) any extraordinary charges or
losses determined in accordance with GAAP, (f) non-cash compensation expenses
arising from the issuance of stock, options to purchase stock and stock
appreciation rights to the management of such Person, and (g) any other non-cash
charges, non-cash expenses or non-cash losses of such Person for such period
(excluding any such charge, expense or loss incurred in the ordinary course of
business that constitutes an accrual of or a reserve for cash charges for any
future period), provided, however, that cash payments made in such period or in
any future period in respect of such non-cash charges, expenses or losses
(excluding any such charge, expense or loss incurred in the ordinary course of
business that constitutes an accrual of or a reserve for cash charges for any
future period) shall be subtracted from Consolidated Net Income in calculating
EBITDA in the period when such payments are made, and minus, to the extent
included in the statement of such Consolidated Net Income for such period, the
sum of (a) interest income, (b) any

                                       6
<PAGE>

extraordinary income or gains determined in accordance with GAAP and (c) any
other non-cash income (excluding any items that represent the reversal of any
accrual of, or cash reserve for, anticipated cash charges in any prior period
that are described in the parenthetical to clause (g) above), all as determined
on a consolidated basis.

            "Employee Stock Purchase Plan": Zila, Inc. Employee Stock Purchase
Plan, approved by Holdings during its annual meeting of stockholders in Phoenix,
Arizona on December 7, 2000.

            "Environmental Laws": any and all foreign, Federal, state, local or
municipal laws, rules, orders, regulations, statutes, ordinances, codes,
decrees, requirements of any Governmental Authority or other Requirements of Law
(including common law) regulating, relating to or imposing liability or
standards of conduct concerning protection of human health or the environment,
as now or may at any time hereafter be in effect.

            "ERISA": the Employee Retirement Income Security Act of 1974, as
amended from time to time.

            "Event of Default": any of the events specified in Section 9;
provided that any requirement for the giving of notice, the lapse of time, or
both, has been satisfied.

            "Excluded Foreign Subsidiary": any Foreign Subsidiary, including,
without limitation, Zila Limited, a corporation organized under the laws of the
United Kingdom, in respect of which either (a) the pledge of all of the Capital
Stock of such Subsidiary as Collateral or (b) the guaranteeing by such
Subsidiary of the Obligations, would, in the good faith judgment of Borrowers,
result in adverse tax consequences to any Borrower.

            "Excluded Indebtedness": all Indebtedness permitted by clauses (a),
(b), (c), (d), (e), (f) and (g) of Section 8.2.

            "Executive Order": as defined in Section 5.23(a).

            "Facility": each of the Term Loan Commitment and the Tack-On Term
Loan Commitment made hereunder.

            "Federal Funds Effective Rate": for any day, the weighted average of
the rates on overnight federal funds transactions with members of the Federal
Reserve System arranged by federal funds brokers, as published on the next
succeeding Business Day by the Federal Reserve Bank of New York, or, if such
rate is not so published for any day that is a Business Day, the average of the
quotations for the day of such transactions received by the Reference Lender
from three federal funds brokers of recognized standing selected by it.

            "Fee Letter": as defined in Section 4.5(b).

            "Foreign Subsidiary": any Subsidiary of any Borrower that is not a
Domestic Subsidiary.

                                       7
<PAGE>

            "Funding Office": the office of the Administrative Agent specified
in Section 11.2 or such other office as may be specified from time to time by
the Administrative Agent as its funding office by written notice to the Borrower
Representative and the Lenders.

            "GAAP": generally accepted accounting principles in the United
States as in effect from time to time.

            "Governmental Authority": any nation or government, any state or
other political subdivision thereof, any agency (including, without limitation,
the Food and Drug Administration and any foreign equivalents thereof),
authority, instrumentality, regulatory body, court, central bank or other entity
exercising executive, legislative, judicial, taxing, regulatory or
administrative functions of or pertaining to government, any securities exchange
and any self-regulatory organization (including, without limitation, the
National Association of Insurance Commissioners).

            "Group Members": the collective reference to the Borrowers and their
respective Subsidiaries.

            "Guarantee and Collateral Agreement": the Guarantee and Collateral
Agreement to be executed and delivered by each Borrower and each Subsidiary
Guarantor, substantially in the form of Exhibit C.

            "Guarantee Obligation": as to any Person (the "Guaranteeing
Person"), any obligation of (a) the Guaranteeing Person or (b) another Person
(including any bank under any letter of credit) to induce the creation of which
the Guaranteeing Person has issued a reimbursement, counterindemnity or similar
obligation, in either case guaranteeing or in effect guaranteeing any
Indebtedness, leases, dividends or other obligations (the "Primary Obligations")
of any other third Person (the "Primary Obligor") in any manner, whether
directly or indirectly, including any obligation of the Guaranteeing Person,
whether or not contingent, (i) to purchase any such Primary Obligation or any
property constituting direct or indirect security therefor, (ii) to advance or
supply funds (1) for the purchase or payment of any such Primary Obligation or
(2) to maintain working capital or equity capital of the Primary Obligor or
otherwise to maintain the net worth or solvency of the Primary Obligor, (iii) to
purchase property, securities or services primarily for the purpose of assuring
the owner of any such Primary Obligation of the ability of the Primary Obligor
to make payment of such Primary Obligation or (iv) otherwise to assure or hold
harmless the owner of any such Primary Obligation against loss in respect
thereof; provided, however, that the term Guarantee Obligation shall not include
endorsements of instruments for deposit or collection in the ordinary course of
business. The amount of any Guarantee Obligation of any Guaranteeing Person
shall be deemed to be the lower of (a) an amount equal to the stated or
determinable amount of the Primary Obligation in respect of which such Guarantee
Obligation is made and (b) the maximum amount for which such Guaranteeing Person
may be liable pursuant to the terms of the instrument embodying such Guarantee
Obligation, unless such Primary Obligation and the maximum amount for which such
Guaranteeing Person may be liable are not stated or determinable, in which case
the amount of such Guarantee Obligation shall be such Guaranteeing Person's
maximum reasonably anticipated liability in respect thereof as determined by the
Borrowers in good faith.

                                       8
<PAGE>

            "Guarantors": the collective reference to the Subsidiary Guarantors.

            "Hedge Agreements": any agreement with respect to any swap, forward,
future or derivative transaction or option or similar agreement involving, or
settled by reference to, one or more rates, currencies, commodities, equity or
debt instruments or securities, or economic, financial or pricing indices or
measures of economic, financial or pricing risk or value or any similar
transaction or any combination of these transactions; provided that no phantom
stock or similar plan providing for payments only on account of services
provided by current or former directors, officers, employees or consultants of
any Borrower or any Subsidiary shall be a Hedge Agreement.

            "Holdings": as defined in the preamble to this Agreement.

            "IDA Documents": the Reimbursement Agreement, dated as of February
6, 2004, between Oxycal Laboratories, Incorporated and Wells Fargo Business
Credit, Inc. and all documents, instrument and agreements delivered in
connection therewith.

            "Indebtedness": of any Person at any date, without duplication, (a)
all indebtedness of such Person for borrowed money, (b) all obligations of such
Person for the deferred purchase price of property or services (other than
current trade payables incurred in the ordinary course of such Person's
business), (c) all obligations of such Person evidenced by notes, bonds,
debentures or other similar instruments, (d) all indebtedness created or arising
under any conditional sale or other title retention agreement with respect to
property acquired by such Person (even though the rights and remedies of the
seller or lender under such agreement in the event of default are limited to
repossession or sale of such property), (e) all Capital Lease Obligations of
such Person, (f) all obligations of such Person, contingent or otherwise, as an
account party or applicant under or in respect of acceptances, letters of
credit, surety bonds or similar arrangements, (g) the liquidation value of all
redeemable preferred Capital Stock of such Person, (h) all Guarantee Obligations
of such Person in respect of obligations of the kind referred to in clauses (a)
through (g) above, (i) all obligations of the kind referred to in clauses (a)
through (h) above secured by (or for which the holder of such obligation has an
existing right, contingent or otherwise, to be secured by) any Lien on property
(including accounts and contract rights) owned by such Person, whether or not
such Person has assumed or become liable for the payment of such obligation, and
(j) for the purposes of Sections 8.2 and 9(e) only, all obligations of such
Person in respect of Hedge Agreements. The Indebtedness of any Person shall
include the Indebtedness of any other entity (including any partnership in which
such Person is a general partner) to the extent such Person is liable therefor
as a result of such Person's ownership interest in or other relationship with
such entity, except to the extent the terms of such Indebtedness expressly
provide that such Person is not liable therefor.

            "Initial Term Lender": Black Diamond Commercial Finance, L.L.C.

            "Insolvency": with respect to any Multiemployer Plan, the condition
that such Plan is insolvent within the meaning of Section 4245 of ERISA.

            "Insolvent": pertaining to a condition of Insolvency.

            "Intellectual Property": as defined in the Guarantee and Collateral
Agreement.

                                       9
<PAGE>

            "Interest Payment Date": as to the Term Loan, the last day of each
month to occur while the Term Loan is outstanding and the final maturity date of
the Term Loan.

            "Investments": as defined in Section 8.8.

            "IRB L/C": that certain letter of credit issued by Wells Fargo Bank
to JPMorgan Institutional Trust Service, as beneficiary, issued on or about
February 6, 2004 with an expiration date of March 15, 2009 and having, as of the
Closing Date, a maximum amount available to be drawn equal to $3,249,000.

            "Lenders": as defined in the preamble hereto; provided, that unless
the context otherwise requires, each reference herein to the Lenders shall be
deemed to include any Conduit Lender.

            "Lien": any mortgage, pledge, hypothecation, assignment, deposit
arrangement, encumbrance, lien (statutory or other), charge or other security
interest or any preference, priority or other security agreement or preferential
arrangement of any kind or nature whatsoever (including any conditional sale or
other title retention agreement and any capital lease having substantially the
same economic effect as any of the foregoing).

            "Loan Documents": this Agreement, the Security Documents, the Fee
Letter, the Warrants, the Registration Rights Agreement and the Notes.

            "Loans": any loan made by any Lender pursuant to this Agreement.

            "Loan Parties": each Group Member that is a party to a Loan
Document.

            "Material Adverse Effect": a material adverse effect on (a) the
business, operations, properties, assets, condition (financial or otherwise),
results of operations, liabilities (including but not limited to contingent
liabilities), prospects or material agreements of any Borrower or any Subsidiary
taken as a whole or (b) the validity or enforceability of this Agreement or any
of the other Loan Documents or the rights or remedies of the Administrative
Agent or the Lenders hereunder or thereunder.

            "Material Contracts": collectively, (a) the contracts and agreements
set forth on Schedule 1.2 and (b) all other contracts, leases, instruments,
guaranties, licenses or other arrangements (other than the Loan Documents) to
which any Borrower or any Subsidiary is or becomes a party as to which the
breach, nonperformance, cancellation or failure to renew by any party thereto
would reasonably be expected to have a Material Adverse Effect.

            "Materials of Environmental Concern": any (i) gasoline or petroleum
(including crude oil or any fraction thereof) or petroleum products or (ii) any
hazardous or toxic substances, materials or wastes, defined or regulated as such
in or under any Environmental Law, including asbestos, polychlorinated biphenyls
and urea-formaldehyde insulation.

            "Maturity Date": March 24, 2008.

                                       10
<PAGE>

            "Mortgaged Properties": the real properties as to which the
Administrative Agent for the benefit of the Lenders shall be granted a Lien
pursuant to the Mortgages.

            "Mortgages": each of the mortgages and deeds of trust made by any
Loan Party in favor of, or for the benefit of, the Administrative Agent for the
benefit of the Lenders, in form and substance reasonably acceptable to the
Administrative Agent.

            "Multiemployer Plan": a Plan that is a multiemployer plan as defined
in Section 4001(a)(3) of ERISA.

            "Net Cash Proceeds": (a) in connection with any Asset Sale or any
Recovery Event, the proceeds thereof in the form of cash and Cash Equivalents
(including any such proceeds received by way of deferred payment of principal
pursuant to a note or installment receivable or purchase price adjustment
receivable or by the Disposition of any non-cash consideration received in
connection therewith or otherwise, but only as and when received) of such Asset
Sale or Recovery Event, net of attorneys' fees, accountants' fees, investment
banking fees, amounts required to be applied to the repayment of Indebtedness
secured by a Lien expressly permitted hereunder on any asset that is the subject
of such Asset Sale or Recovery Event (other than any Lien pursuant to a Security
Document), in the case of the Prescott Sale/Leaseback, any amount of
Indebtedness prepaid by the Borrowers prior to the consummation of such Prescott
Sale/Leaseback as required by the definitive sale and leaseback documentation
which are satisfactory to the Administrative Agent, and other customary fees and
expenses actually incurred in connection therewith and net of taxes paid or
reasonably estimated to be payable as a result thereof (after taking into
account any available tax credits or deductions and any tax sharing
arrangements) and (b) in connection with any issuance or sale of Capital Stock,
any capital contribution or any incurrence of Indebtedness, the cash proceeds
received from such issuance, contribution or incurrence (including, without
limitation, any cash proceeds received by any Group Member from the exercise of
any stock options or warrants by the holders thereof), net of attorneys' fees,
investment banking fees, accountants' fees, underwriting discounts and
commissions and other customary fees and expenses actually incurred in
connection therewith; provided, however, to the extent there are any cash
proceeds from the exercise of the Warrants, such proceeds shall be applied to
the Loans in the sole discretion of the Administrative Agent.

            "Nutraceuticals Business": the business operated by Zila
Nutraceuticals, Inc. (formerly known as Oxycal Laboratories Incorporated).

            "Non-Excluded Taxes": as defined in Section 4.8.

            "Non-U.S. Lender": as defined in Section 4.8.

            "Notes": the collective reference to any promissory notes evidencing
the Facility.

            "Obligations": the unpaid principal of and interest on (including
interest accruing after the maturity of the Loans and interest accruing after
the filing of any petition in bankruptcy, or the commencement of any insolvency,
reorganization or like proceeding, relating to any Borrower, whether or not a
claim for post-filing or post-petition interest is allowed in such proceeding)
the Loans and all other obligations and liabilities of the Borrowers to the

                                       11
<PAGE>

Administrative Agent or to any Lender whether direct or indirect, absolute or
contingent, due or to become due, or now existing or hereafter incurred, which
may arise under, out of, or in connection with, this Agreement, any other Loan
Document, or any other document made, delivered or given in connection herewith
or therewith, whether on account of principal, interest, reimbursement
obligations, fees, indemnities, costs, expenses (including all fees, charges and
disbursements of counsel to the Administrative Agent or to any Lender that are
required to be paid by the Borrowers pursuant hereto) or otherwise.

            "Other Taxes": any and all present or future stamp or documentary
taxes or any other excise or property taxes, charges or similar levies arising
from any payment made hereunder or from the execution, delivery or enforcement
of, or otherwise with respect to, this Agreement or any other Loan Document.

            "Participant": as defined in Section 11.6(c).

            "PBGC": the Pension Benefit Guaranty Corporation established
pursuant to Subtitle A of Title IV of ERISA (or any successor).

            "Person": an individual, partnership, corporation, limited liability
company, business trust, joint stock company, trust, unincorporated association,
joint venture, Governmental Authority or other entity of whatever nature.

            "Plan": at a particular time, any employee benefit plan that is
covered by ERISA and in respect of which any Borrower or a Commonly Controlled
Entity is (or, if such plan were terminated at such time, would under Section
4069 of ERISA be deemed to be) an "employer" as defined in Section 3(5) of
ERISA.

            "Prescott Facility": that certain owned real property and facilities
of Zila Nutraceuticals, Inc. located at 6735 Inter-Cal Way, Prescott, Arizona
86301.

            "Prescott Sale/Leaseback": the sale-leaseback of the Prescott
Facility pursuant to terms, conditions and documentation satisfactory to the
Administrative Agent.

            "Pro Forma Balance Sheet": as defined in Section 5.1(a).

            "Projections": as defined in Section 7.2(c).

            "Properties": as defined in Section 5.17(a).

            "Property": any right or interest in or to property of any kind
whatsoever, whether real, personal or mixed and whether tangible or intangible,
including, without limitation, Capital Stock.

            "Recovery Event": any settlement of or payment in respect of any
property or casualty insurance claim or any condemnation proceeding relating to
any asset of any Group Member.

            "Reference Lender": Black Diamond Commercial Finance, L.L.C.

                                       12
<PAGE>

            "Register": as defined in Section 11.6(b).

            "Registration Rights Agreement": that certain Registration Rights
Agreement, dated as of the date hereof, among Holdings and the Initial Term
Lender in the form of Exhibit H.

            "Regulation U": Regulation U of the Board as in effect from time to
time.

            "Reorganization": with respect to any Multiemployer Plan, the
condition that such plan is in reorganization within the meaning of Section 4241
of ERISA.

            "Reportable Event": any of the events set forth in Section 4043(b)
of ERISA, other than those events as to which the thirty day notice period is
waived under subsection .27, .28, .29, .30, .31, .32, .34 or .35 of PBGC Reg.
Section 4043.

            "Required Lenders": at any time, the holders of more than 50% of (a)
until the Closing Date, the Term Loan Commitments then in effect and (b)
thereafter, the sum of the aggregate unpaid principal amount of the Term Loan
then outstanding.

            "Requirement of Law": as to any Person, the Certificate of
Incorporation and By-Laws or other organizational or governing documents of such
Person, and any law, treaty, rule or regulation or determination of an
arbitrator or a court or other Governmental Authority, in each case applicable
to or binding upon such Person or any of its property or to which such Person or
any of its property is subject.

            "Responsible Officer": the chief executive officer, president or
chief financial officer of Holdings, but in any event, with respect to financial
matters, the chief financial officer of Holdings.

            "Restricted Cash": the aggregate amount of cash collateral deposited
with Wells Fargo Bank for the unpaid IRB L/C in an amount not to exceed
$3,650,000.

            "Restricted Payments": as defined in Section 8.6.

            "Ryker's Worker's Compensation Claim": that certain worker's
compensation claim brought by Dennis R. O'Neill against Ryker Dental of
Kentucky, Inc. d/b/a Zila Dental Supply, Inc. in an amount of up to $10,000.

            "Scientific Advisory Board": that certain scientific advisory board
appointed by Zila Nutraceuticals, Inc. to provide scientific advice and guidance
to Holdings and its Subsidiaries.

            "SEC": the Securities and Exchange Commission, any successor thereto
and any analogous Governmental Authority.

            "Security Documents": the collective reference to the Guarantee and
Collateral Agreement, the Mortgages, the Control Agreements and all other
security documents hereafter

                                       13
<PAGE>

delivered to the Administrative Agent granting a Lien on any property of any
Person to secure the obligations and liabilities of any Loan Party under any
Loan Document.

            "Single Employer Plan": any Plan that is covered by Title IV of
ERISA, but that is not a Multiemployer Plan.

            "Solvent": when used with respect to any Person, means that, as of
any date of determination, (a) the amount of the "present fair saleable value"
of the assets of such Person will, as of such date, exceed the amount of all
"liabilities of such Person, contingent or otherwise", as of such date, as such
quoted terms are determined in accordance with applicable federal and state laws
governing determinations of the insolvency of debtors, (b) the present fair
saleable value of the assets of such Person will, as of such date, be greater
than the amount that will be required to pay the liability of such Person on its
debts as such debts become absolute and matured, (c) such Person will not have,
as of such date, an unreasonably small amount of capital with which to conduct
its business, and (d) such Person will be able to pay its debts as they mature.
For purposes of this definition, (i) "debt" means liability on a "claim", and
(ii) "claim" means any (x) right to payment, whether or not such a right is
reduced to judgment, liquidated, unliquidated, fixed, contingent, matured,
unmatured, disputed, undisputed, legal, equitable, secured or unsecured or (y)
right to an equitable remedy for breach of performance if such breach gives rise
to a right to payment, whether or not such right to an equitable remedy is
reduced to judgment, fixed, contingent, matured or unmatured, disputed,
undisputed, secured or unsecured.

            "Stockholder" means, with respect to any Person, each holder of
Capital Stock of such Person.

            "Subsidiary": as to any Person, a corporation, partnership, limited
liability company or other entity of which shares of stock or other ownership
interests having ordinary voting power (other than stock or such other ownership
interests having such power only by reason of the happening of a contingency) to
elect a majority of the board of directors or other managers of such
corporation, partnership or other entity are at the time owned, or the
management of which is otherwise controlled, directly or indirectly through one
or more intermediaries, or both, by such Person. Unless otherwise qualified, all
references to a "Subsidiary" or to "Subsidiaries" in this Agreement shall refer
to a Subsidiary or Subsidiaries of any Borrower.

            "Subsidiary Guarantor": each Subsidiary of any Borrower other than
any Excluded Foreign Subsidiary.

            "Supporting Obligations": all "supporting obligations" as such term
is defined in the Uniform Commercial Code, including letters of credit and
guaranties issued in support of Accounts, chattel paper, documents, general
intangibles, instruments, or investment property.

            "Tack-On Term Loan": as defined in Section 3.1.

            "Tack-On Term Loan Commitment": as to any Lender, the obligation of
such Lender, if any, to make a Tack-On Term Loan to the Borrowers hereunder in
an aggregate face amount not to exceed the amount set forth under the heading
"Tack-On Term Loan

                                       14
<PAGE>

Commitment" under such Lender's name in the Assignment and Assumption pursuant
to which such Lender became a party hereto, as the same may be changed from time
to time pursuant to the terms hereof. The original aggregate amount of the
Tack-On Term Loan Commitment is $20,000,000.

            "Tack-On Term Loan Lenders": each Lender that has a Tack-On Term
Loan Commitment.

            "Term Loan": as defined in Section 2.1.

            "Term Note": as defined in Section 2.1.

            "Term Loan Commitment": as to any Lender, the obligation of such
Lender, if any, to make a Term Loan to the Borrowers hereunder in a principal
amount not to exceed the amount set forth under the heading "Term Loan
Commitment" under such Lender's name in the Assignment and Assumption pursuant
to which such Lender became a party hereto, as the same may be changed from time
to time pursuant to the terms hereof. The original aggregate amount of the Term
Loan Commitment is $20,0000,000.

            "Term Loan Lender": each Lender that has a Term Loan Commitment or
that holds a Term Loan.

            "Term Percentage": as to any Term Loan Lender at any time, the
percentage which the aggregate principal amount of such Lender's portion of the
Term Loan then outstanding constitutes of the aggregate principal amount of the
Term Loan then outstanding.

            "Transferee": any Assignee or Participant.

            "UBS Account": that certain securities account with the account
number CP-40244-16 in the name of Zila Biotechnology, Inc. at UBS Financial
Services, Inc., located at One North Wacker Drive, #2500, Chicago, IL 60606.

            "Uniform Commercial Code": the Uniform Commercial Code of the State
of New York or of any other state the laws of which are required to be applied
in connection with the perfection of security interests in any Collateral.

            "United States": the United States of America.

            "Warrants": defined in Section 2.3 and in the form of Exhibit G.

            "Warrant Documents": the collective reference to the Registration
Rights Agreement, Warrants and all other documents hereafter delivered to the
Initial Term Lender granting warrants in Holdings to the Initial Term Lender.

            "Wholly Owned Subsidiary": as to any Person, any other Person all of
the Capital Stock of which (other than directors' qualifying shares required by
law) is owned by such Person directly and/or through other Wholly Owned
Subsidiaries.

                                       15
<PAGE>

            "Wholly Owned Subsidiary Guarantor": any Subsidiary Guarantor that
is a Wholly Owned Subsidiary of the Borrower.

            "Worker's Compensation Board": the Worker's Compensation Board of
the State of Kentucky.

            1.2 Other Definitional Provisions. (a) Unless otherwise specified
therein, all terms defined in this Agreement shall have the defined meanings
when used in the other Loan Documents or any certificate or other document made
or delivered pursuant hereto or thereto.

            (b) As used herein and in the other Loan Documents, and any
certificate or other document made or delivered pursuant hereto or thereto, (i)
accounting terms relating to any Group Member not defined in Section 1.1 and
accounting terms partly defined in Section 1.1, to the extent not defined, shall
have the respective meanings given to them under GAAP, (ii) the words "include",
"includes" and "including" shall be deemed to be followed by the phrase "without
limitation", (iii) the word "incur" shall be construed to mean incur, create,
issue, assume, become liable in respect of or suffer to exist (and the words
"incurred" and "incurrence" shall have correlative meanings), (iv) the words
"asset" and "property" shall be construed to have the same meaning and effect
and to refer to any and all tangible and intangible assets and properties,
including cash, Capital Stock, securities, revenues, accounts, leasehold
interests and contract rights, and (v) references to agreements or other
Contractual Obligations shall, unless otherwise specified, be deemed to refer to
such agreements or Contractual Obligations as amended, supplemented, restated or
otherwise modified from time to time (subject to any applicable restrictions
hereunder).

            (c) The words "hereof", "herein" and "hereunder" and words of
similar import when used in this Agreement shall refer to this Agreement as a
whole and not to any particular provision of this Agreement, and Section,
Schedule and Exhibit references are to this Agreement unless otherwise
specified.

            (d) The meanings given to terms defined herein shall be equally
applicable to both the singular and plural forms of such terms.

            (e) Except as otherwise expressly provided herein, all terms of an
accounting or financial nature shall be construed in accordance with GAAP;
provided that, if the Borrower Representative notifies the Administrative Agent
that the Borrowers request an amendment to any provision hereof to eliminate the
effect of any change occurring after the date hereof in GAAP or in the
application thereof on the operation of such provision (or if the Administrative
Agent notifies the Borrower Representative that the Required Lenders request an
amendment to any provision hereof for such purpose), regardless of whether any
such notice is given before or after such change in GAAP or in the application
thereof, then such provision shall be interpreted on the basis of GAAP as in
effect and applied immediately before such change shall have become effective
until such notice shall have been withdrawn or such provision amended in
accordance herewith.

                                       16
<PAGE>

                                   SECTION 2.

             AMOUNT AND TERMS OF TERM LOAN COMMITMENTS AND WARRANTS

            2.1 Term Loan. Subject to the terms and conditions hereof, the
Initial Term Lender agrees to make a term loan (a "Term Loan") to the Borrowers
on the Closing Date in an amount not to exceed the original aggregate amount of
the Term Loan Commitment. The Administrative Agent shall credit the account of
the Borrowers on the books of such office of the Administrative Agent with the
aggregate of the amounts made available to the Administrative Agent by the
Initial Term Lender in immediately available funds. The obligations of each
Lender hereunder shall be several and not joint. The Term Loan shall be
evidenced by Term Loan promissory notes that, in the aggregate, do not exceed
the original aggregate amount of the Term Loan Commitment and are substantially
in the form of Exhibit E (each a "Term Note" and collectively, the "Term
Notes"). If requested by a Term Loan Lender the Borrowers shall jointly execute
and deliver a Term Note to the applicable Term Loan Lender in the original
aggregate amount of such Term Loan Lender's Term Loan Commitment; provided,
however, that aggregate amount of all Term Notes shall not exceed the original
aggregate amount of the Term Loan Commitment.

            2.2 Repayment of Term Loan. The aggregate outstanding principal
balance, together with accrued interest, of the Term Loan and all other amounts
due hereunder shall be due and payable in full in immediately available funds on
the Maturity Date, if not sooner paid in full. No payment with respect to the
Term Loan may be reborrowed.

            2.3 Warrants. The Borrowers have authorized the issuance, sale and
delivery of its warrants, initially exercisable to purchase an aggregate of up
to 1,200,000 shares (subject to adjustment as therein provided) of its Common
Stock, at an initial exercise price of $3.79 per share (subject to adjustment as
therein provided) to be substantially in the form of Exhibit G (all such
Warrants originally issued pursuant to this Agreement, or delivered in
substitution or exchange for any thereof, being collectively called the
"Warrants" and individually a "Warrant").

                                   SECTION 3.

                                TACK-ON TERM LOAN

            3.1 Tack-On Term Loan. At any time, the Borrowers, through the
Borrower Representative, may solicit the Administrative Agent and Lenders,
reasonably satisfactory to the Administrative Agent and the Borrowers, to
provide the Borrowers with an incremental term loan (the "Tack-On Term Loan").
The aggregate amount of the Tack-On Term Loan shall not exceed the aggregate
Tack-On Term Loan Commitment and shall be on terms (including, without
limitation, pricing, structure and fees) mutually acceptable to the Borrowers
and the Administrative Agent. The Tack-On Term Loan may, in the sole discretion
of the Administrative Agent and the Lenders, be made available to the Borrowers
and neither the Administrative Agent nor any Lender shall have any obligation to
the Borrowers to fund all or any part of such Tack-On Term Loan Commitment or to
solicit Lenders to fund such Tack-On Term Loan. To the extent the Administrative
Agent and the Lenders, in their sole discretion, elect to make the Tack-On Term
Loan and the Tack-On Term Loan Commitment available to the

                                       17
<PAGE>

Borrowers after the Closing Date, the Borrowers, the Lenders and the
Administrative Agent agree to negotiate in good faith, such amendments to this
Agreement and such other documentation as may be reasonably necessary or
required, in the determination of the Administrative Agent, to evidence the
Tack-On Term Loan and the availability of the Tack-On Term Loan Commitment.

                                   SECTION 4.

                 GENERAL PROVISIONS APPLICABLE TO THE TERM LOAN

            4.1 Optional Prepayments. The Borrowers may at any time and from
time to time prepay the Term Loan, in whole or in part, subject to Section 4.3
below, upon irrevocable notice delivered to the Administrative Agent no later
than 11:00 A.M., New York City time, three (3) Business Days prior to the
proposed date of repayment. Upon receipt of any such notice the Administrative
Agent shall promptly notify each relevant Lender thereof. If any such notice is
given, the amount specified in such notice shall be due and payable on the date
specified therein, together with accrued interest to such date on the amount
prepaid. Partial prepayments of Term Loan shall be in an aggregate principal
amount of $1,000,000 or a whole multiple in excess thereof.

            4.2 Mandatory Prepayments and Commitment Reductions. (a) If any
Capital Stock or Indebtedness shall be issued or incurred by any Group Member
(other than Excluded Indebtedness, any Capital Stock issued to any Group Member
and Capital Stock issued pursuant to the Employee Stock Purchase Plan) or any
capital contribution is made to any Group Member (other than a capital
contribution by any Group Member), an amount equal to 100% of the Net Cash
Proceeds thereof shall be applied on the date of such issuance, incurrence or
contribution toward the prepayment of the Term Loan set forth in Section 4.2(c).

            (b) If on any date any Group Member shall receive Net Cash Proceeds
from any Asset Sale or Recovery Event then such Net Cash Proceeds shall be
applied on such date toward the prepayment of the Term Loan; provided, that, to
the extent any prepayment pursuant to this clause (b) is made with the Net Cash
Proceeds from the Prescott Sale/Leaseback, then the Borrowers shall only be
required to apply toward the prepayment of the Term Loan an amount equal to 50%
of the aggregate Net Cash Proceeds received by any Group Member from the
Prescott Sale/Leaseback; provided, further, that:

            (c) Each prepayment of the Term Loan under Section 4.2 shall be
accompanied by accrued interest to the date of such prepayment on the amount
prepaid. So long as no Default or Event of Default shall have occurred and be
continuing any prepayments by the Borrowers shall be applied as follows: first,
to fees and reimbursable expenses of the Administrative Agent then due and
payable pursuant to any of the Loan Documents; second, to interest then due and
payable on the Term Loan, including any interest required to be paid pursuant to
Section 4.3; third, to prepay the principal balance of the Term Loan until
prepaid in full; fourth, to all other Obligations, including expenses of Lenders
to the extent reimbursable under Section 11.5; and fifth, the remaining to the
Borrowers or such other Person legally entitled thereto.

                                       18
<PAGE>

            4.3 Make-Whole. In the event the Borrowers prepay the Term Loan, in
whole or in part, pursuant to Section 4.2 (including, without limitation, to the
extent such prepayment is made utilizing the proceeds of the Prescott
Sale/Leaseback to the extent required by Section 4.2(b), whether prior to or
after the Closing Date) on or prior to the six month anniversary of the Closing
Date, the Borrowers agree to pay to the Administrative Agent for the pro rata
account of the Lenders, (i) the aggregate accrued but unpaid interest on the
Term Loans to the date of such prepayment on the amount prepaid and (ii) an
additional amount equal to the aggregate amount of interest the Lenders would
have earned on the Term Loan had such prepayment not been made during the period
from the date of such prepayment through and including the six-month anniversary
of the Closing Date.

            4.4 Interest Rates and Default Rate of Interest. Interest shall
accrue on the Term Loan for each day at a rate per annum determined in
accordance with the Applicable Margin and shall be payable monthly in arrears
(i) in cash as set forth in the column heading "Cash Interest" portion of the
Applicable Margin and (ii) in kind as set forth in the column heading "PIK
Interest" portion of the Applicable Margin. After the occurrence and during the
continuance of an Event of Default, at the election of the Administrative Agent
(or upon the written request of the Required Lenders) all unpaid principal and
interest on the Loans, together with all other outstanding Obligations
hereunder, shall bear interest at the rate per annum determined in accordance
with the Applicable Margin plus an additional 2% in cash and shall be payable in
arrears on demand in cash as set forth in the column heading "Cash Interest"
portion of the Applicable Margin, from the date of such Event of Default until
such amount is paid in full (as well after as before judgment). The unpaid
principal balance of the Loans, together with any and all interest accrued and
unpaid thereon, automatically and unconditionally shall be due and payable in
cash in full which shall be made on the Maturity Date.

            4.5 Computation of Interest and Fees. (a) Interest and fees payable
pursuant hereto shall be calculated on the basis of a 365- (or 366-, as the case
may be) day year for the actual days elapsed.

            (b) The Borrowers jointly and severally agree to pay to the
Administrative Agent the fees specified in the Fee Letter, dated as of the date
hereof, among the Borrowers and the Administrative Agent (the "Fee Letter") at
the times specified for payment therein.

            4.6 Pro Rata Treatment and Payments. (a) Each borrowing by the
Borrowers from the Lenders hereunder, each payment by the Borrowers on account
of any commitment fee and any reduction of the Commitments of the Lenders shall
be made pro rata according to the respective Term Percentages of the relevant
Term Loan Lenders.

            (b) Each payment (including each prepayment) by the Borrowers on
account of principal of and interest on the Term Loan shall be made pro rata
according to the respective outstanding principal amounts of the Term Loan then
held by the Term Loan Lenders. Amounts prepaid on account of the Term Loan may
not be reborrowed.

            (c) All payments (including prepayments) to be made by the Borrowers
hereunder, whether on account of principal, interest, fees or otherwise, shall
be made without setoff or counterclaim and shall be made prior to 12:00 Noon,
New York City time, on the due

                                       19
<PAGE>

date thereof to the Administrative Agent, for the account of the Lenders, at the
Funding Office, in Dollars and in immediately available funds. The
Administrative Agent shall distribute such payments to the Lenders promptly upon
receipt in like funds as received. If any payment hereunder becomes due and
payable on a day other than a Business Day, such payment shall be extended to
the next succeeding Business Day. In the case of any extension of any payment of
principal pursuant to the preceding sentence, interest thereon shall be payable
at the then applicable rate during such extension.

            (d) Unless the Administrative Agent shall have been notified in
writing by the Borrower Representative prior to the date of any payment due to
be made by the Borrowers hereunder that the Borrowers will not make such payment
to the Administrative Agent, the Administrative Agent may assume that the
Borrowers are making such payment, and the Administrative Agent may, but shall
not be required to, in reliance upon such assumption, make available to the
Lenders their respective pro rata shares of a corresponding amount. If such
payment is not made to the Administrative Agent by the Borrowers within three
(3) Business Days after such due date, the Administrative Agent shall be
entitled to recover, on demand, from each Lender to which any amount which was
made available pursuant to the preceding sentence, such amount with interest
thereon at the rate per annum equal to the daily average Federal Funds Effective
Rate. Nothing herein shall be deemed to limit the rights of the Administrative
Agent or any Lender against the Borrowers.

            4.7 Requirements of Law. (a) If the adoption of or any change in any
Requirement of Law or in the interpretation or application thereof by a
Governmental Authority, asserting appropriate jurisdictional authority, or
compliance by any Lender with any request or directive from any Governmental
Authority, asserting appropriate jurisdictional authority, made subsequent to
the date hereof:

                  (i) shall subject any Lender to any tax of any kind whatsoever
            with respect to this Agreement, or change the basis of taxation of
            payments to such Lender in respect thereof (except for Non-Excluded
            Taxes covered by Section 4.8 and changes in the rate of tax on the
            overall net income of such Lender);

                  (ii) shall impose, modify or hold applicable any reserve,
            special deposit, compulsory loan or similar requirement against
            assets held by, deposits or other liabilities in or for the account
            of, advances, loans or other extensions of credit by, or any other
            acquisition of funds by, any office of such Lender; or

                  (iii) shall impose on such Lender any other condition;

and the result of any of the foregoing is to increase the cost to such Lender,
by an amount that such Lender deems to be material, of maintaining the Loans, or
to reduce any amount receivable hereunder in respect thereof, then, in any such
case, the Borrowers shall promptly pay such Lender, upon its demand, any
additional amounts necessary to compensate such Lender for such increased cost
or reduced amount receivable. If any Lender becomes entitled to claim any
additional amounts pursuant to this paragraph, it shall promptly notify the
Borrower Representative (with a copy to the Administrative Agent) of the event
by reason of which it has become so entitled.

                                       20
<PAGE>

            (b) If any Lender shall have determined that the adoption of or any
change in any Requirement of Law regarding capital adequacy or in the
interpretation or application thereof or compliance by such Lender or any
corporation controlling such Lender with any request or directive regarding
capital adequacy from any Governmental Authority made subsequent to the date
hereof shall have the effect of reducing the rate of return on such Lender's or
such corporation's capital as a consequence of its obligations hereunder to a
level below that which such Lender or such corporation could have achieved but
for such adoption, change or compliance (taking into consideration such Lender's
or such corporation's policies with respect to capital adequacy) by an amount
deemed by such Lender to be material, then from time to time, after submission
by such Lender to the Borrower Representative (with a copy to the Administrative
Agent) of a written request therefor, the Borrowers shall pay to such Lender
such additional amount or amounts as will compensate such Lender or such
corporation for such reduction.

            (c) A certificate as to any additional amounts payable pursuant to
this Section submitted by any Lender to the Borrower Representative (with a copy
to the Administrative Agent) shall be conclusive in the absence of manifest
error. Notwithstanding anything to the contrary in this Section, the Borrowers
shall not be required to compensate a Lender pursuant to this Section for any
amounts incurred more than six months prior to the date that such Lender
notifies the Borrower Representative of such Lender's intention to claim
compensation therefor; provided that, if the circumstances giving rise to such
claim have a retroactive effect, then such six-month period shall be extended to
include the period of such retroactive effect.

            4.8 Taxes. (a) All payments made by the Borrowers under this
Agreement shall be made free and clear of, and without deduction or withholding
for or on account of, any present or future income, stamp or other taxes,
levies, imposts, duties, charges, fees, deductions or withholdings, now or
hereafter imposed, levied, collected, withheld or assessed by any Governmental
Authority, excluding net income taxes and franchise taxes (imposed in lieu of
net income taxes) imposed on the Administrative Agent or any Lender as a result
of a present or former connection between the Administrative Agent or such
Lender and the jurisdiction of the Governmental Authority imposing such tax or
any political subdivision or taxing authority thereof or therein (other than any
such connection arising solely from the Administrative Agent or such Lender
having executed, delivered or performed its obligations or received a payment
under, or enforced, this Agreement or any other Loan Document). If any such
non-excluded taxes, levies, imposts, duties, charges, fees, deductions or
withholdings ("Non-Excluded Taxes") or Other Taxes are required to be withheld
from any amounts payable to the Administrative Agent or any Lender hereunder,
the amounts so payable to the Administrative Agent or such Lender shall be
increased to the extent necessary to yield to the Administrative Agent or such
Lender (after payment of all Non-Excluded Taxes and Other Taxes) interest or any
such other amounts payable hereunder at the rates or in the amounts specified in
this Agreement, provided, however, that the Borrowers shall not be required to
increase any such amounts payable to any Lender with respect to any Non-Excluded
Taxes (i) that are attributable to such Lender's failure to comply with the
requirements of paragraph (d) or (e) of this Section or (ii) that are United
States withholding taxes imposed on amounts payable to such Lender at the time
such Lender becomes a party to this Agreement, except to the extent that such
Lender's assignor (if any) was entitled, at the time of assignment, to receive
additional amounts from the Borrowers with respect to such Non-Excluded Taxes
pursuant to this paragraph.

                                       21
<PAGE>

            (b) In addition, the Borrowers shall pay any Other Taxes to the
relevant Governmental Authority in accordance with applicable law.

            (c) Whenever any Non-Excluded Taxes or Other Taxes are payable by
any Borrower, as promptly as possible thereafter such Borrower shall send to the
Administrative Agent for its own account or for the account of the relevant
Lender, as the case may be, a certified copy of an original official receipt
received by such Borrower showing payment thereof. If any Borrower fails to pay
any Non-Excluded Taxes or Other Taxes when due to the appropriate taxing
authority or fails to remit to the Administrative Agent the required receipts or
other required documentary evidence, such Borrower shall indemnify the
Administrative Agent and the Lenders for any incremental taxes, interest or
penalties that may become payable by the Administrative Agent or any Lender as a
result of any such failure.

            (d) Each Lender (or Transferee) that is not a "U.S. Person" as
defined in Section 7701(a)(30) of the Code (a "Non-U.S. Lender") shall deliver
to the Borrower Representative and the Administrative Agent (or, in the case of
a Participant, to the Lender from which the related participation shall have
been purchased) two copies of either U.S. Internal Revenue Service Form W-8BEN
or Form W-8ECI, or, in the case of a Non-U.S. Lender claiming exemption from
U.S. federal withholding tax under Section 871(h) or 881(c) of the Code with
respect to payments of "portfolio interest", a statement substantially in the
form of Exhibit D and a Form W-8BEN, or any subsequent versions thereof or
successors thereto, properly completed and duly executed by such Non-U.S. Lender
claiming complete exemption from, or a reduced rate of, U.S. federal withholding
tax on all payments by the Borrowers under this Agreement and the other Loan
Documents. Such forms shall be delivered by each Non-U.S. Lender on or before
the date it becomes a party to this Agreement (or, in the case of any
Participant, on or before the date such Participant purchases the related
participation). In addition, each Non-U.S. Lender shall deliver such forms
promptly upon the obsolescence or invalidity of any form previously delivered by
such Non-U.S. Lender. Each Non-U.S. Lender shall promptly notify the Borrower
Representative at any time it determines that it is no longer in a position to
provide any previously delivered certificate to the Borrower Representative (or
any other form of certification adopted by the U.S. taxing authorities for such
purpose). Notwithstanding any other provision of this paragraph, a Non-U.S.
Lender shall not be required to deliver any form pursuant to this paragraph that
such Non-U.S. Lender is not legally able to deliver.

            (e) A Lender that is entitled to an exemption from or reduction of
non-U.S. withholding tax under the law of the jurisdiction in which any Borrower
is located, or any treaty to which such jurisdiction is a party, with respect to
payments under this Agreement shall deliver to the Borrower Representative (with
a copy to the Administrative Agent), at the time or times prescribed by
applicable law or reasonably requested by the Borrower Representative, such
properly completed and executed documentation prescribed by applicable law as
will permit such payments to be made without withholding or at a reduced rate;
provided that such Lender is legally entitled to complete, execute and deliver
such documentation and in such Lender's judgment such completion, execution or
submission would not materially prejudice the legal position of such Lender.

                                       22
<PAGE>

            (f) If the Administrative Agent or any Lender determines, in its
sole discretion, that it has received a refund of any Non-Excluded Taxes or
Other Taxes as to which it has been indemnified by the Borrowers or with respect
to which the Borrowers have paid additional amounts pursuant to this Section
4.8, it shall pay over such refund to the Borrower Representative (but only to
the extent of indemnity payments made, or additional amounts paid, by the
Borrowers under this Section 4.8 with respect to the Non-Excluded Taxes or Other
Taxes giving rise to such refund), net of all out-of-pocket expenses of such
Agent or such Lender and without interest (other than any interest paid by the
relevant Governmental Authority with respect to such refund); provided, that the
Borrowers, upon the request of such Agent or such Lender, agree to repay the
amount paid over to the Borrower Representative (plus any penalties, interest or
other charges imposed by the relevant Governmental Authority) to the
Administrative Agent or such Lender in the event the Administrative Agent or
such Lender is required to repay such refund to such Governmental Authority.
This paragraph shall not be construed to require the Administrative Agent or any
Lender to make available its tax returns (or any other information relating to
its taxes which it deems confidential) to the Borrowers or any other Person.

            (g) The agreements in this Section shall survive the termination of
this Agreement and the payment of the Loans and all other amounts payable
hereunder.

            4.9 Change of Lending Office. Each Lender agrees that, upon the
occurrence of any event giving rise to the operation of Section 4.10 or 4.11(a)
with respect to such Lender, it will, if requested by the Borrower
Representative, use reasonable efforts (subject to overall policy considerations
of such Lender) to designate another lending office for any Loans affected by
such event with the object of avoiding the consequences of such event; provided,
that such designation is made on terms that, in the sole judgment of such
Lender, cause such Lender and its lending office(s) to suffer no economic, legal
or regulatory disadvantage, and provided, further, that nothing in this Section
shall affect or postpone any of the obligations of any Borrower or the rights of
any Lender pursuant to Section 4.7 or 4.8(a).

            4.10 Replacement of Lenders. The Borrowers shall be permitted to
replace any Lender that (a) requests reimbursement for amounts owing pursuant to
Section 4.7 or 4.8(a) or (b) defaults in its obligation to make Loans hereunder,
with a replacement financial institution; provided that (i) such replacement
does not conflict with any Requirement of Law, (ii) no Event of Default shall
have occurred and be continuing at the time of such replacement, (iii) the
replacement financial institution shall purchase, at par, all amounts under the
Loans and other amounts owing to such replaced Lender on or prior to the date of
replacement, (iv) the replacement financial institution, if not already a
Lender, shall be reasonably satisfactory to the Administrative Agent, (v) the
replaced Lender shall be obligated to make such replacement in accordance with
the provisions of Section 11.6 (provided that the Borrowers shall be obligated
to pay the registration and processing fee referred to therein), (vi) until such
time as such replacement shall be consummated, the Borrowers shall pay all
additional amounts (if any) required pursuant to Section 4.7 or 4.8(a), as the
case may be, and (vii) any such replacement shall not be deemed to be a waiver
of any rights that the Borrowers, the Administrative Agent or any other Lender
shall have against the replaced Lender.

                                       23
<PAGE>

            4.11 Evidence of Debt. (a) Each Lender shall maintain in accordance
with its usual practice an account or accounts evidencing indebtedness of the
Borrowers to such Lender resulting from each Loan of such Lender from time to
time, including the amounts of principal and interest payable and paid to such
Lender from time to time under this Agreement.

            (b) The Administrative Agent, on behalf of the Borrowers, shall
maintain the Register pursuant to Section 11.6(d), and a subaccount therein for
each Lender, in which shall be recorded (i) the amount of the Loans made
hereunder and any Note evidencing the Loans, (ii) the amount of any principal or
interest due and payable or to become due and payable from the Borrowers to each
Lender hereunder and (iii) both the amount of any sum received by the
Administrative Agent hereunder from the Borrowers and each Lender's share
thereof.

            (c) The entries made in the Register and the accounts of each Lender
maintained pursuant to Section 4.11 shall, to the extent permitted by applicable
law, be prima facie evidence of the existence and amounts of the obligations of
the Borrowers therein recorded; provided, however, that the failure of any
Lender or the Administrative Agent to maintain the Register or any such account,
or any error therein, shall not in any manner affect the obligation of the
Borrowers to repay (with applicable interest) the Loans made to the Borrowers by
such Lender in accordance with the terms of this Agreement.

            4.12 Reliance on Notices; Appointment of Borrower Representative.
Each Borrower hereby designates Borrower Representative as its representative
and agent on its behalf for the purposes of giving and receiving any notices and
consents hereunder or under any of the other Loan Documents and taking all other
actions (including in respect of compliance with covenants) on behalf of any
Borrower or Borrowers under the Loan Documents. Borrower Representative hereby
accepts such appointment. The Administrative Agent and each Lender may regard
any notice or other communication pursuant to any Loan Document from Borrower
Representative as a notice or communication from all Borrowers, and may give any
notice or communication required or permitted to be given to any Borrower or
Borrowers hereunder to Borrower Representative on behalf of such Borrower or
Borrowers. Each Borrower agrees that each notice, election, representation and
warranty, covenant, agreement and undertaking made on its behalf by Borrower
Representative shall be deemed for all purposes to have been made by such
Borrower and shall be binding upon and enforceable against such Borrower to the
same extent as if the same had been made directly by such Borrower.

                                   SECTION 5.

                         REPRESENTATIONS AND WARRANTIES

            To induce the Administrative Agent and the Lenders to enter into
this Agreement and to make the Loans, subject to the terms and conditions
hereof, the Borrowers hereby jointly and severally represent and warrant to the
Administrative Agent and each Lender that:

            5.1 Financial Condition. (a) The unaudited pro forma consolidated
balance sheet of Holdings and its Subsidiaries as at January 31, 2006 (including
the notes thereto) (the "Pro Forma Balance Sheet"), copies of which have
heretofore been furnished to each Lender, has been prepared giving effect (as if
such events had occurred on such date) to (i) the Term Loan to

                                       24
<PAGE>

be made on the Closing Date and the use of proceeds thereof and (ii) the payment
of fees and expenses in connection with the foregoing. The Pro Forma Balance
Sheet has been prepared based on the best information available to the Borrowers
as of the date of delivery thereof, and presents fairly on a pro forma basis the
estimated financial position of Holdings and its Subsidiaries on a consolidated
basis as at January 31, 2006, assuming that the events specified in the
preceding sentence had actually occurred at such date.

            (b) The audited consolidated balance sheets of Holdings and its
Subsidiaries as at July 31, 2005, July 31, 2004 and July 31, 2003, and the
related consolidated statements of income and of cash flows for the fiscal years
ended on such dates, reported on by and accompanied by an unqualified report
from (i) BDO Seidman, LLP, for the year ending July 31, 2005 and (ii) Deloitte &
Touche, LLP, for the years ending July 31, 2004 and July 31, 2003, present
fairly the consolidated financial condition of Holdings and its Subsidiaries as
at such date, and the consolidated results of its operations and its
consolidated cash flows for the respective fiscal years then ended. The
unaudited consolidated balance sheet of Holdings and its Subsidiaries as at the
end of each quarter ended subsequent to October 31, 2005, and the related
unaudited consolidated statements of income and cash flows for the respective
quarterly period then ended on such dates, present fairly the consolidated
financial condition of Holdings and its Subsidiaries as at such dates, and the
consolidated results of its operations and its consolidated cash flows for the
respective quarterly periods then ended (subject to normal year-end audit
adjustments). All such financial statements, including the related schedules and
notes thereto, have been prepared in accordance with GAAP applied consistently
throughout the periods involved (except as approved by the aforementioned firm
of accountants and disclosed therein). No Group Member has any material
Guarantee Obligations, contingent liabilities and liabilities for taxes, or any
long-term leases or unusual forward or long-term commitments, including any
interest rate or foreign currency swap or exchange transaction or other
obligation in respect of derivatives, that are not reflected in the most recent
financial statements referred to in this paragraph. During the period from
October 31, 2005 to and including the date hereof there has been no Disposition
by Holdings or any Group Member of any material part of its business or
property.

            5.2 No Change. Since January 31, 2006, there has been no development
or event that has had or could reasonably be expected to have a Material Adverse
Effect.

            5.3 Corporate Existence; Compliance with Law. Each Group Member (a)
is duly organized, validly existing and in good standing under the laws of the
jurisdiction of its organization, (b) has the power and authority, and the legal
right, to own and operate its property, to lease the property it operates as
lessee and to conduct the business in which it is currently engaged, (c) is duly
qualified as a foreign corporation and in good standing under the laws of each
jurisdiction where its ownership, lease or operation of property or the conduct
of its business requires such qualification and (d) is in compliance with all
Requirements of Law, permits and agreements except to the extent that the
failure to comply therewith could not, in the aggregate, reasonably be expected
to have a Material Adverse Effect.

            5.4 Power; Authorization; Enforceable Obligations. Each Loan Party
has the power and authority, and the legal right, to make, deliver and perform
the Loan Documents to which it is a party and, in the case of the Borrowers, to
obtain extensions of credit hereunder.

                                       25
<PAGE>

Each Loan Party has taken all necessary organizational action to authorize the
execution, delivery and performance of the Loan Documents to which it is a party
and, in the case of the Borrowers, to authorize the extensions of credit on the
terms and conditions of this Agreement. No consent or authorization of, filing
with, notice to or other act by or in respect of, any Governmental Authority or
any other Person is required in connection with the extensions of credit
hereunder or with the execution, delivery, performance, validity or
enforceability of this Agreement or any of the Loan Documents, except (i)
consents, authorizations, filings and notices described in Schedule 5.4, which
consents, authorizations, filings and notices have been obtained or made and are
in full force and effect and (ii) the filings and recordings referred to in
Section 5.19. Each Loan Document has been duly executed and delivered on behalf
of each Loan Party which is a party thereto. This Agreement constitutes, and
each other Loan Document upon execution will constitute, a legal, valid and
binding obligation of each Loan Party which is a party thereto, enforceable
against each such Loan Party in accordance with its terms, except as
enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting the enforcement of
creditors' rights generally and by general equitable principles (whether
enforcement is sought by proceedings in equity or at law).

            5.5 No Legal Bar. The execution, delivery and performance of this
Agreement and the other Loan Documents, the borrowings hereunder and the use of
the proceeds thereof will not violate any Requirement of Law or any Contractual
Obligation of any Group Member and will not result in, or require, the creation
or imposition of any Lien on any of their respective properties or revenues
pursuant to any Requirement of Law or any such Contractual Obligation (other
than the Liens created by the Security Documents). No Requirement of Law or
Contractual Obligation applicable to any Borrower or any Subsidiary could
reasonably be expected to have a Material Adverse Effect.

            5.6 Litigation. No litigation, investigation or proceeding of or
before any arbitrator or Governmental Authority is pending or, to the knowledge
of any Borrower, threatened by or against any Group Member or against any of
their respective properties or revenues (a) with respect to any of the Loan
Documents or any of the transactions contemplated hereby or thereby, or (b) that
could reasonably be expected to have a Material Adverse Effect.

            5.7 No Default. No Group Member is in default under or with respect
to any of its Contractual Obligations in any respect that could reasonably be
expected to have a Material Adverse Effect. No Default or Event of Default has
occurred and is continuing.

            5.8 Ownership of Property; Liens. Each Group Member has title in fee
simple to, or a valid leasehold interest in, all its real property, and good
title to, or a valid leasehold interest in, all its other property, and none of
such property is subject to any Lien except as permitted by Section 8.3.

            5.9 Intellectual Property. Each Group Member owns, or is licensed to
use, all Intellectual Property necessary for the conduct of its business as
currently conducted; no material claim has been asserted and is pending by any
Person challenging or questioning the use of any Intellectual Property or the
validity or effectiveness of any Intellectual Property, nor does any Borrower
know of any valid basis for any such claim; and the use of Intellectual Property
by each Group Member does not infringe on the rights of any Person in any
material respect.

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<PAGE>

            5.10 Taxes. Each Group Member has filed or caused to be filed all
Federal, state and other material tax returns that are required to be filed and
has paid all taxes shown to be due and payable on said returns or on any
assessments made against it or any of its property and all other taxes, fees or
other charges imposed on it or any of its property by any Governmental Authority
(other than any amounts the validity of which are currently being contested in
good faith by appropriate proceedings and with respect to which reserves in
conformity with GAAP have been provided on the books of any Borrower or any
Subsidiary, as the case may be). No tax Lien has been filed, and, to the
knowledge of any Borrower, no claim is being asserted, with respect to any such
tax, fee or other charge.

            5.11 Federal Regulations. No part of the proceeds of the Loans, and
no other extensions of credit hereunder, will be used for "buying" or "carrying"
any "margin stock" within the respective meanings of each of the quoted terms
under Regulation U as now and from time to time hereafter in effect or for any
purpose that violates the provisions of the Regulations of the Board. If
requested by any Lender or the Administrative Agent, the Borrowers will furnish
to the Administrative Agent and each Lender a statement to the foregoing effect
in conformity with the requirements of FR Form G-3 or FR Form U-1, as
applicable, referred to in Regulation U.

            5.12 Labor Matters. Except as, in the aggregate, could not
reasonably be expected to have a Material Adverse Effect: (a) there are no
strikes or other labor disputes against any Group Member pending or, to the
knowledge of any Borrower, threatened; (b) hours worked by and payment made to
employees of each Group Member have not been in violation of the Fair Labor
Standards Act or, to the knowledge of any Borrower, any other applicable
Requirement of Law dealing with such matters; and (c) all payments due from any
Group Member on account of employee health and welfare insurance have been paid
or accrued as a liability on the books of the relevant Group Member.

            5.13 ERISA. Neither a Reportable Event nor an "accumulated funding
deficiency" (within the meaning of Section 412 of the Code or Section 302 of
ERISA) has occurred during the five-year period prior to the date on which this
representation is made or deemed made with respect to any Plan, and each Plan
has complied in all material respects with the applicable provisions of ERISA
and the Code. No termination of a Single Employer Plan has occurred, and no Lien
in favor of the PBGC or a Plan has arisen, during such five-year period. The
present value of all accrued benefits under each Single Employer Plan (based on
those assumptions used to fund such Plans) did not, as of the last annual
valuation date prior to the date on which this representation is made or deemed
made, exceed the value of the assets of such Plan allocable to such accrued
benefits by a material amount. Neither any Borrower nor any Commonly Controlled
Entity has had a complete or partial withdrawal from any Multiemployer Plan that
has resulted or could reasonably be expected to result in a material liability
under ERISA, and neither any Borrower nor any Commonly Controlled Entity would
become subject to any material liability under ERISA if any such Borrower or any
such Commonly Controlled Entity were to withdraw completely from all
Multiemployer Plans as of the valuation date most closely preceding the date on
which this representation is made or deemed made. No such Multiemployer Plan is
in Reorganization or Insolvent.

                                       27
<PAGE>

            5.14 Investment Company Act; Other Regulations. No Loan Party is an
"investment company", or a company "controlled" by an "investment company",
within the meaning of the Investment Company Act of 1940, as amended. No Loan
Party is subject to regulation under any Requirement of Law (other than
Regulation X of the Board) that limits its ability to incur Indebtedness or
which otherwise may render all or any portion of the Obligations unenforceable.

            5.15 Subsidiaries. Except as disclosed to the Administrative Agent
by the Borrower Representative in writing from time to time after the Closing
Date, Schedule 5.15 sets forth the name and jurisdiction of incorporation of
each Subsidiary and, as to each such Subsidiary, the percentage of each class of
Capital Stock owned by any Loan Party. The shares of Common Stock issuable upon
exercise of the Warrants have been duly and validly reserved for issuance upon
such exercise and, when issued and delivered against payment therefor as
provided therein, will be duly authorized, validly issued, fully paid and non
assessable and subject to no Liens created by the Borrowers in respect of the
issuance thereof. Except for the options and warrants set forth on Schedule
5.15(a) and except for the Warrants issued as of the Closing Date, there are no
outstanding subscriptions, options, warrants, calls, rights or other agreements
or commitments (other than stock options granted to employees or directors and
directors' qualifying shares) of any nature relating to any Capital Stock of any
Borrower or any Subsidiary, except as created by the Loan Documents. In
addition, Ryker Dental of Kentucky, Inc. does not (i) hold any assets, (ii) have
any active business operations or (iii) have any debt or other liabilities
(other than in relation to the Ryker's Worker's Compensation Claim).

            5.16 Use of Proceeds. (a) On the Closing Date, the proceeds of the
Term Loan shall be used (i) to refinance certain existing indebtedness of the
Borrowers, (ii) to finance a portion of the research and development costs
related to the Bio/Pharma Operations, (iii) to pay related fees and expenses,
and (iv) for other general corporate purposes; and (b) if made available after
the Closing Date, the proceeds of the Tack-On Term Loan shall be used (i) for
other general corporate purposes and (ii) to pay related fees and expenses.

            5.17 Environmental Matters. Except as, in the aggregate, could not
reasonably be expected to have a Material Adverse Effect:

            (a) the facilities and properties owned, leased or operated by any
      Group Member (the "Properties") do not contain, and have not previously
      contained, any Materials of Environmental Concern in amounts or
      concentrations or under circumstances that constitute or constituted a
      violation of, or could give rise to liability under, any Environmental
      Law;

            (b) no Group Member has received or is aware of any notice of
      violation, alleged violation, non-compliance, liability or potential
      liability regarding environmental matters or compliance with Environmental
      Laws with regard to any of the Properties or the business operated by any
      Group Member (the "Business"), nor does any Group Member have knowledge or
      reason to believe that any such notice will be received or is being
      threatened;

                                       28
<PAGE>

            (c) Materials of Environmental Concern have not been transported or
      disposed of from the Properties in violation of, or in a manner or to a
      location that could give rise to liability under, any Environmental Law,
      nor have any Materials of Environmental Concern been generated, treated,
      stored or disposed of at, on or under any of the Properties in violation
      of, or in a manner that could reasonably be expected to give rise to
      liability under, any applicable Environmental Law;

            (d) no judicial proceeding or governmental or administrative action
      is pending or, to the knowledge of any Borrower, threatened, under any
      Environmental Law to which any Group Member is or will be named as a party
      with respect to the Properties or the Business, nor are there any consent
      decrees or other decrees, consent orders, administrative orders or other
      orders, or other administrative or judicial requirements outstanding under
      any Environmental Law with respect to the Properties or the Business;

            (e) there has been no release or threat of release of Materials of
      Environmental Concern at or from the Properties, or arising from or
      related to the operations of any Group Member in connection with the
      Properties or otherwise in connection with the Business, in violation of
      or in amounts or in a manner that could reasonably be expected to give
      rise to liability under Environmental Laws;

            (f) the Properties and all operations at the Properties are in
      compliance, and have in the last five years, if such Properties have been
      owned, leased or operated by any Group Member during such period, been in
      compliance, with all applicable Environmental Laws, and there is, to the
      knowledge of any Borrower, no contamination at, under or about the
      Properties or violation of any Environmental Law with respect to the
      Properties or the Business; and

            (g) no Group Member has assumed any liability of any other Person
      under Environmental Laws.

            5.18 Accuracy of Information, etc. No statement or information
contained in this Agreement, any other Loan Document, or in any other documents,
certificate or statement furnished by or on behalf of any Loan Party to the
Administrative Agent or the Lenders, or any of them, for use in connection with
the transactions contemplated by this Agreement or the other Loan Documents,
contained, as of the date such statement, information, document or certificate
was so furnished, any untrue statement of a material fact or omitted to state a
material fact necessary to make the statements contained herein or therein not
misleading. The projections and pro forma financial information contained in the
materials referenced above are based upon good faith estimates and assumptions
believed by management of each Borrower to be reasonable at the time made, it
being recognized by the Lenders that such financial information as it relates to
future events is not to be viewed as fact and that actual results during the
period or periods covered by such financial information may differ from the
projected results set forth therein by a material amount. There is no fact known
to any Loan Party that could reasonably be expected to have a Material Adverse
Effect that has not been expressly disclosed herein, in the other Loan
Documents, or in any other documents, certificates and statements furnished to
the Administrative Agent and the Lenders for use in connection with the
transactions contemplated hereby and by the other Loan Documents.

                                       29
<PAGE>

            5.19 Security Documents. (a) The Guarantee and Collateral Agreement
is effective to create in favor of the Administrative Agent, for the benefit of
the Lenders, a legal, valid and enforceable security interest in the Collateral
described therein and proceeds thereof. In the case of the Pledged Stock as
defined and described in the Guarantee and Collateral Agreement, when stock
certificates representing such Pledged Stock are delivered to the Administrative
Agent, and in the case of the other Collateral described in the Guarantee and
Collateral Agreement, when financing statements and other filings specified on
Schedule 5.19(a) in appropriate form are filed in the offices specified on
Schedule 5.19(a), the Guarantee and Collateral Agreement shall constitute a
fully perfected Lien on, and security interest in, all right, title and interest
of the Loan Parties in such Collateral and the proceeds thereof, as security for
the Obligations (as defined in the Guarantee and Collateral Agreement), in each
case prior and superior in right to any other Person (except, in the case of
Collateral other than Pledged Stock, Liens permitted by Section 8.3).

            (b) Each of the Mortgages is effective to create in favor of the
Administrative Agent, for the benefit of the Lenders, a legal, valid and
enforceable Lien on the Mortgaged Properties described therein and proceeds
thereof, and when the Mortgages are filed in the offices specified on Schedule
5.19(b), each such Mortgage shall constitute a fully perfected Lien on, and
security interest in, all right, title and interest of the Loan Parties in the
Mortgaged Properties and the proceeds thereof, as security for the Obligations
(as defined in the relevant Mortgage), in each case prior and superior in right
to any other Person. Schedule 1.1 lists, as of the Closing Date, each parcel of
owned real property and each leasehold interest in real property located in the
United States and held by any Borrower or any Subsidiary.

            (c) Each of the Control Agreements is effective to create in favor
of the Administrative Agent, for the benefit of the Lenders, a legal, valid and
enforceable Lien in each of the deposit accounts (other than Excluded Accounts)
identified as such on Schedule 5.19, subject to no adverse claims.

            5.20 Deposit Accounts. As of the Closing Date, Schedule 5.20 lists
all banks and other financial institutions at which any Loan Party maintains
deposit or other accounts, and such Schedule 5.20 correctly identifies the name,
address and telephone number of each depository, the name in which the account
is held, a description of the purpose of the account, and the complete account
number therefor.

            5.21 Solvency. Each Loan Party is, and after giving effect to the
incurrence of all Indebtedness and obligations being incurred in connection
herewith and therewith will be and will continue to be, Solvent.

            5.22 Foreign Assets Control Regulations. Neither any Borrower nor,
to the knowledge of any Borrower, any Affiliate of such Borrower, is, or will be
after consummation of the transactions contemplated by the Loan Documents and
application of the proceeds of the Loans, by reason of being a "national" of a
"designated foreign country" or a "specially designated national" within the
meaning of the Regulations of the Office of Foreign Assets Control, United
States Treasury Department (31 C.F.R., Subtitle B, Chapter V), or for any other
reason, in violation of any United States Federal statute or Presidential
Executive Order

                                       30
<PAGE>

concerning trade or other relations with any foreign country or any citizen or
national thereof or the ownership or operation of any property.

            5.23 Anti-Terrorism Laws.

            (a) Neither any Borrower nor, to the knowledge of any Borrower, any
of such Borrower's Affiliates is in violation of any laws relating to terrorism
or money laundering ("Anti-Terrorism Laws"), including Executive Order No. 13224
on Terrorist Financing, effective September 24, 2001 (the "Executive Order"),
and the Uniting and Strengthening America by Providing Appropriate Tools
Required to Intercept and Obstruct Terrorism Act of 2001, Public Law 107-56.

            (b) Neither any Borrower nor, to the knowledge of any Borrower, any
Affiliate or broker or other agent of such Borrower acting or benefiting in any
capacity in connection with the Loans is any of the following:

                  (i) a Person that is listed in the annex to, or is otherwise
            subject to the provisions of, the Executive Order;

                  (ii) a Person owned or controlled by, or acting for or on
            behalf of, any Person that is listed in the annex to, or is
            otherwise subject to the provisions of, the Executive Order;

                  (iii) a Person with which any Lender is prohibited from
            dealing or otherwise engaging in any transaction by any
            Anti-Terrorism Law; or

                  (iv) a Person that commits, threatens or conspires to commit
            or supports "terrorism" as defined in the Executive Order.

            (c) Neither any Borrower nor, to the knowledge of any Borrower, any
broker or other agent of such Borrower acting in any capacity in connection with
the Loans (i) conducts any business or engages in making or receiving any
contribution of funds, goods or services to or for the benefit of any Person
described in paragraph (b) above, (ii) deals in, or otherwise engages in any
transaction relating to, any property or interests in property blocked pursuant
to the Executive Order or (iii) engages in or conspires to engage in any
transaction that evades or avoids, or has the purpose of evading or avoiding, or
attempts to violate, any of the prohibitions set forth in any Anti-Terrorism
Law.

            5.24 Regulation H. No Mortgage encumbers improved real property that
is located in an area that has been identified by the Secretary of Housing and
Urban Development as an area having special flood hazards and in which flood
insurance has been made available under the National Flood Insurance Act of
1968.

                                       31
<PAGE>

                                   SECTION 6.

                              CONDITIONS PRECEDENT

            6.1 Conditions to Extension of Term Loan. The agreement of the
Initial Term Lender to make the Term Loan on the Closing Date is subject to the
satisfaction, prior to or concurrently with the making of such extension of
credit on the Closing Date, of the following conditions precedent:

            (a) Credit Agreement; Security Documents; Warrant Documents. The
Administrative Agent shall have received (i) this Agreement executed and
delivered by the Administrative Agent, each Borrower and the Initial Term Lender
as of the Closing Date, (ii) the Security Documents, executed and delivered by
each Borrower and each Subsidiary Guarantor that is a party to such Security
Document, (iii) an Acknowledgment and Consent in the form attached to the
Guarantee and Collateral Agreement, executed and delivered by each Issuer (as
defined therein), if any, that is not a Loan Party, (iv) the Control Agreements,
executed and delivered by the Administrative Agent, the applicable Loan Party
and the applicable bank and (v) the Warrant Documents, executed and delivered by
Holdings and the Initial Term Lender.

            (b) Pro Forma Balance Sheet; Financial Statements. The Initial Term
Lender shall have received the financial statements described in Section 5.1.

            (c) Approvals. All governmental and third party approvals (including
landlords' and other consents) necessary in connection with the continuing
operations of the Group Members and the transactions contemplated hereby shall
have been obtained and be in full force and effect, and all applicable waiting
periods shall have expired without any action being taken or threatened by any
competent authority that would restrain, prevent or otherwise impose adverse
conditions on the financing contemplated hereby.

            (d) Lien Searches. The Administrative Agent shall have received the
results of a recent lien search in each of the jurisdictions where assets of the
Loan Parties are located, and such search shall reveal no liens on any of the
assets of the Loan Parties except for liens permitted by Section 8.3 or
discharged on or prior to the Closing Date pursuant to documentation
satisfactory to the Administrative Agent.

            (e) Fees. The Initial Term Lender and the Administrative Agent shall
have received all fees required to be paid, and all expenses for which invoices
have been presented (including the reasonable fees and expenses of legal
counsel), on or before the Closing Date. All such amounts will be paid with
proceeds of the Term Loan made on the Closing Date and will be reflected in the
funding instructions given by the Borrower Representative to the Administrative
Agent on or before the Closing Date.

            (f) Closing Certificate. The Administrative Agent shall have
received (i) a certificate of each Loan Party, dated the Closing Date,
substantially in the form of Exhibit F, with appropriate insertions and
attachments including the certificate of incorporation of each Loan Party that
is a corporation certified by the relevant authority of the jurisdiction of

                                       32
<PAGE>

organization of such Loan Party, and (ii) a long form good standing certificate
for each Loan Party from its jurisdiction of organization.

            (g) Legal Opinions. The Administrative Agent shall have received the
following executed legal opinions:

                  (i) the legal opinion of Snell & Wilmer L.L.P., counsel to the
            Borrowers; and

                  (ii) the legal opinion of local counsel in New York and of
            such other special and local counsel as may be required by the
            Administrative Agent.

Each such legal opinion shall cover such other matters incident to the
transactions contemplated by this Agreement as the Administrative Agent may
reasonably require.

            (j) Pledged Stock; Stock Powers; Pledged Notes. The Administrative
      Agent shall have received (i) the certificates representing the shares of
      Capital Stock pledged pursuant to the Guarantee and Collateral Agreement,
      together with an undated stock power for each such certificate executed in
      blank by a duly authorized officer of the pledgor thereof and (ii) each
      promissory note (if any) pledged to the Administrative Agent pursuant to
      the Guarantee and Collateral Agreement endorsed (without recourse) in
      blank (or accompanied by an executed transfer form in blank) by the
      pledgor thereof.

            (k) Filings, Registrations and Recordings. Each document (including
      any Uniform Commercial Code financing statement) required by the Security
      Documents or under law or reasonably requested by the Administrative Agent
      to be filed, registered or recorded in order to create in favor of the
      Administrative Agent, for the benefit of the Lenders, a perfected Lien on
      the Collateral described therein, prior and superior in right to any other
      Person (other than with respect to Liens expressly permitted by Section
      8.3), shall be in proper form for filing, registration or recordation.

            (l) Solvency Certificate. The Administrative Agent shall have
      received a solvency certificate from the chief financial officer of
      Holdings which shall be in form and substance reasonably satisfactory to
      the Administrative Agent.

            (m) Insurance. The Administrative Agent shall have received
      insurance certificates satisfying the requirements of Section 5.3(b) of
      the Guarantee and Collateral Agreement.

            (n) Control Agreement. Borrowers shall have established Control
      Agreements pursuant to the requirements set forth in Section 5.19
      satisfactory in the sole discretion of the Administrative Agent.

            (o) Pay-off Letters. The Administrative Agent shall have received
      pay-off letters, termination statements, canceled mortgages and the like
      reasonably required by the Administrative Agent in connection with the
      removal of any liens (except for liens permitted by Section 8.3) against
      the assets of any of the Loan Parties.

                                       33
<PAGE>

            (p) Licenses. Evidence that each Borrower is duly licensed or
      qualified to transact business in all jurisdictions where the character of
      the property owned or leased or the nature of the business transacted by
      it makes such licensing or qualification necessary.

            (q) Minimum Cash. The Borrowers shall have delivered evidence to the
      satisfaction of the Administrative Agent demonstrating that, after giving
      effect to the borrowings of the Term Loan on the Closing Date, the
      Borrowers shall have unrestricted cash and Cash Equivalents and Restricted
      Cash in an aggregate amount equal to at least $14,800,000.

            (r) Such other documents as the Administrative Agent in its sole
      discretion may require.

            6.2 Conditions to Extension of Tack-On Term Loan. In addition to the
conditions set forth in Section 3.1, the agreement of the Tack-On Term Loan
Lenders to advance the Tack-On Term Loan pursuant to the Tack-On Term Loan
Commitment shall be subject to the satisfaction of the following conditions
precedent:

            (a) Fees. The Administrative Agent and the Tack-On Term Loan Lenders
      shall have received all fees required to be paid, and all expenses for
      which invoices have been presented (including the reasonable fees and
      expenses of legal counsel), or before the date of such extension.

            (b) Representations and Warranties. Each of the representations and
      warranties made by any Loan Party in or pursuant to the Loan Documents
      shall be true and correct on and as of such date as if made on and as of
      such date.

            (c) No Default. No Default or Event of Default shall have occurred
      and be continuing on such date or after giving effect to the extensions of
      credit requested to be made on such date.

            (d) Due Diligence. The Administrative Agent and the Lenders shall
      have completed their business due diligence and legal due diligence, with
      results satisfactory to the Administrative Agent.

            (e) Acquisition Documents. The Administrative Agent shall have
      received copies of executed acquisition documentation, in form and
      substance reasonably satisfactory to the Administrative Agent, relating to
      the acquisition of a complimentary business to the Bio/Pharma Operations.

            (f) Such other conditions as the Administrative Agent and the
      Lenders in their sole discretion may require.

                                       34
<PAGE>

                                   SECTION 7.

                              AFFIRMATIVE COVENANTS

            The Borrowers hereby jointly and severally agree that, so long as
the Commitments remain in effect or any Loans or other amount is owing to any
Lender or the Administrative Agent hereunder, the Borrowers shall and shall
cause each of their respective Subsidiaries to:

            7.1 Financial Statements. Furnish to the Administrative Agent and
each Lender:

            (a) as soon as available, but in any event within 90 days after the
      end of each fiscal year of Holdings, a copy of the audited consolidated
      balance sheet of Holdings and its Subsidiaries as at the end of such year
      and the related audited consolidated statements of income and of cash
      flows for such year, setting forth in each case in comparative form the
      figures for the previous year, reported on without a "going concern" or
      like qualification or exception, or qualification arising out of the scope
      of the audit, by BDO Seidman, LLP or other independent certified public
      accountants of nationally recognized standing;

            (b) as soon as available, but in any event not later than 45 days
      after the end of each quarterly periods of the fiscal year of Holdings,
      the unaudited consolidated and consolidating balance sheet of Holdings and
      its Subsidiaries as at the end of such quarter and the related unaudited
      consolidated and consolidating statements of income and the related
      unaudited consolidated statements of cash flows for such quarter and the
      portion of the fiscal year through the end of such quarter, setting forth
      in each case in comparative form the figures for the previous year,
      certified by a Responsible Officer as being fairly stated in all material
      respects (subject to normal year-end audit adjustments); and

            (c) as soon as available, but in any event not later than 25 days
      after the end of each month occurring during the fiscal year of Holdings
      (other than the third, sixth, ninth and twelfth such month), the unaudited
      consolidated and consolidating balance sheets of Holdings and its
      Subsidiaries as at the end of such month and the related unaudited
      consolidated and consolidating statements of income and the related
      unaudited consolidated statements of cash flows for such month and the
      portion of the fiscal year through the end of such month, setting forth in
      each case in comparative form the figures for the previous year, certified
      by a Responsible Officer as being fairly stated in all material respects
      (subject to normal year-end audit adjustments).

All such financial statements shall be complete and correct in all material
respects and shall be prepared in reasonable detail and in accordance with GAAP
applied consistently throughout the periods reflected therein and with prior
periods (except as approved by such accountants or officer, as the case may be,
and disclosed therein).

                                       35
<PAGE>

            7.2 Certificates; Other Information. Furnish to the Administrative
Agent and each Lender (or, in the case of clause (g), to the relevant Lender):

            (a) concurrently with the delivery of the financial statements
      referred to in Section 7.1(a), a certificate of the independent certified
      public accountants reporting on such financial statements stating that in
      making the examination necessary therefor no knowledge was obtained of any
      Default or Event of Default, except as specified in such certificate;

            (b) concurrently with the delivery of any financial statements
      pursuant to Section 7.1, (i) a certificate of a Responsible Officer
      stating that, to the best of each such Responsible Officer's knowledge,
      each Loan Party during such period has observed or performed all of its
      covenants and other agreements, and satisfied every condition, contained
      in this Agreement and the other Loan Documents to which it is a party to
      be observed, performed or satisfied by it, and that such Responsible
      Officer has obtained no knowledge of any Default or Event of Default
      except as specified in such certificate, (ii) a Compliance Certificate
      containing all information and calculations necessary for determining
      compliance by each Group Member with the provisions of this Agreement
      referred to therein as of the last day of the fiscal quarter or fiscal
      year of Holdings and (iii) to the extent not previously disclosed to the
      Administrative Agent, a listing of any Intellectual Property acquired by
      any Loan Party since the date of the most recent list delivered pursuant
      to this clause (iii) (or, in the case of the first such list so delivered,
      since the Closing Date);

            (c) as soon as available, and in any event no later than 30 days
      prior to the end of each fiscal year of Holdings, a detailed consolidated
      budget for the following fiscal year (including a projected consolidated
      balance sheet of Holdings and its Subsidiaries as of the end of the
      following fiscal year, the related consolidated statements of projected
      cash flow, projected changes in financial position and projected income
      and a description of the underlying assumptions applicable thereto), and
      shall be reasonably satisfactory to the Administrative Agent, and, as soon
      as available, significant revisions, if any, of such budget and
      projections with respect to such fiscal year (collectively, the
      "Projections"), which Projections shall in each case be accompanied by a
      certificate of a Responsible Officer stating that such Projections have
      been approved by the board of directors of Holdings and are based on
      reasonable estimates, information and assumptions and that such
      Responsible Officer has no reason to believe that such Projections are
      incorrect or misleading in any material respect;

            (d) if any Borrower is not then a reporting company under the
      Securities Exchange Act of 1934, as amended, within 45 days after the end
      of each fiscal quarter of such Borrower (or 90 days, in the case of the
      last fiscal quarter of any fiscal year), a narrative discussion and
      analysis of the financial condition and results of operations of such
      Borrower and its Subsidiaries for such fiscal quarter and for the period
      from the beginning of the then current fiscal year to the end of such
      fiscal quarter, as compared to the portion of the Projections covering
      such periods and to the comparable periods of the previous year;

                                       36
<PAGE>

            (e) within five days after the same are sent, copies of all
      financial statements and reports that any Borrower sends to the holders of
      any class of its debt securities or public equity securities and, within
      five days after the same are filed, copies of all financial statements and
      reports that such Borrower may make to, or file with, the SEC;

            (f) promptly, such additional financial and other information as any
      Lender may from time to time reasonably request; and

            (g) within five days after receipt thereof by any Loan Party, copies
      of all management letters or similar letters or reports received by such
      Loan Party from its independent certified public accountants.

            7.3 Payment of Obligations. Pay, discharge or otherwise satisfy at
or before maturity or before they become delinquent, as the case may be, all its
material obligations of whatever nature, including, without limitation, payment
of any taxes, social security and unemployment withholding with respect to its
employees, except where the amount or validity thereof is currently being
contested in good faith by appropriate proceedings and reserves in conformity
with GAAP with respect thereto have been provided on the books of the relevant
Group Member.

            7.4 Maintenance of Existence; Compliance. (a) (i) Preserve, renew
and keep in full force and effect its organizational existence; provided,
however, that the Borrowers shall cause the dissolution and winding up of Ryker
Dental of Kentucky, Inc. on or before sixty (60) days following the date that a
final determination in favor of Ryker Dental of Kentucky, Inc. is issued by the
Worker's Compensation Board on the Ryker's Worker's Compensation Claim and (ii)
take all reasonable action to maintain all rights, privileges, licenses and
franchises necessary or desirable in the normal conduct of its business, except,
in each case, as otherwise permitted by Section 8.4 and except, in the case of
clause (ii) above, to the extent that failure to do so could not reasonably be
expected to have a Material Adverse Effect; and (b) comply with all Contractual
Obligations and Requirements of Law except to the extent that failure to comply
therewith could not, in the aggregate, reasonably be expected to have a Material
Adverse Effect.

            7.5 Maintenance of Property; Insurance. (a) Keep all property useful
and necessary in its business in good working order and condition, ordinary wear
and tear excepted and (b) maintain with financially sound and reputable
insurance companies insurance on all its property in at least such amounts and
against at least such risks (but including in any event public liability,
product liability and business interruption) as are usually insured against in
the same general area by companies engaged in the same or a similar business.

            7.6 Inspection of Property; Books and Records; Discussions. (a) Keep
proper books of records and accounts in which full, true and correct entries in
conformity with GAAP and all Requirements of Law shall be made of all dealings
and transactions in relation to its business and activities and (b) permit the
Administrative Agent and representatives of any Lender to visit and inspect any
of its properties and examine and make abstracts from any of its books and
records at any reasonable time and as often as may reasonably be desired and to
discuss the business, operations, properties and financial and other condition
of the Group Members with officers and employees of the Group Members and , so
long as the Group

                                       37
<PAGE>

Members are afforded a reasonable opportunity to be present during any such
discussions, with their independent certified public accountants; provided,
however, unless an Event of Default shall have occurred and be continuing, the
Administrative Agent and such Lender (as applicable) shall first consult with
the Borrowers concerning the subject matter and scope of any such discussions
before the Administrative Agent or such Lender shall engage in any such
discussions with any Group Member's independent certified public accountants.

            7.7 Notices. Promptly give notice to the Administrative Agent and
each Lender of:

            (a) the occurrence of any Default or Event of Default;

            (b) any (i) default or event of default under any Contractual
      Obligation of any Group Member or (ii) litigation, investigation or
      proceeding that may exist at any time between any Group Member and any
      Governmental Authority, that in either case, if not cured or if adversely
      determined, as the case may be, could reasonably be expected to have a
      Material Adverse Effect;

            (c) any litigation or proceeding affecting any Group Member (i) in
      which the amount involved is $500,000 or more and not covered by
      insurance, (ii) in which injunctive or similar relief is sought or (iii)
      which relates to any Loan Document;

            (d) the following events, as soon as possible and in any event
      within 30 days after any Borrower knows or has reason to know thereof: (i)
      the occurrence of any Reportable Event with respect to any Plan, a failure
      to make any required contribution to a Plan, the creation of any Lien in
      favor of the PBGC or a Plan or any withdrawal from, or the termination,
      Reorganization or Insolvency of, any Multiemployer Plan or (ii) the
      institution of proceedings or the taking of any other action by the PBGC
      or any Borrower or any Commonly Controlled Entity or any Multiemployer
      Plan with respect to the withdrawal from, or the termination,
      Reorganization or Insolvency of, any Plan; and

            (e) any development or event that has had or could reasonably be
      expected to have a Material Adverse Effect.

Each notice pursuant to this Section 7.7 shall be accompanied by a statement of
a Responsible Officer setting forth details of the occurrence referred to
therein and stating what action the relevant Group Member proposes to take with
respect thereto.

            7.8 Environmental Laws. (a) Comply with, and ensure compliance in
all material respects by all tenants and subtenants, if any, with, all
applicable Environmental Laws, and obtain and comply with and maintain, and
ensure that all tenants and subtenants obtain and comply in all material
respects with and maintain, any and all licenses, approvals, notifications,
registrations or permits required by applicable Environmental Laws.

            (b) Conduct and complete all investigations, studies, sampling and
testing, and all remedial, removal and other actions required under
Environmental Laws and promptly comply with all lawful orders and directives of
all Governmental Authorities regarding Environmental Laws.

                                       38
<PAGE>

            7.9 Additional Collateral, etc. (a) With respect to any property
acquired after the Closing Date by any Group Member (other than (x) any property
described in paragraph (c) or (d) below and any interests real property, (y) any
property subject to a Lien expressly permitted by Section 8.3(f) and (z)
property acquired by any Excluded Foreign Subsidiary) as to which the
Administrative Agent, for the benefit of the Lenders, does not have a perfected
Lien, promptly (i) execute and deliver to the Administrative Agent such
amendments to the Guarantee and Collateral Agreement or such other documents as
the Administrative Agent deems necessary or advisable to grant to the
Administrative Agent, for the benefit of the Lenders, a security interest in
such property and (ii) take all actions necessary or advisable to grant to the
Administrative Agent, for the benefit of the Lenders, a perfected first priority
security interest in such property, including the filing of Uniform Commercial
Code financing statements in such jurisdictions as may be required by the
Guarantee and Collateral Agreement or by law or as may be requested by the
Administrative Agent.

            (b) With respect to any fee interest in any real property having a
value (together with improvements thereof) of at least $500,000 acquired after
the Closing Date by any Group Member (other than (x) any such real property
subject to a Lien expressly permitted by Section 8.3(f) and (y) real property
acquired by any Excluded Foreign Subsidiary), promptly (i) execute and deliver a
first priority Mortgage, in favor of the Administrative Agent, for the benefit
of the Lenders, covering such real property, (ii) if requested by the
Administrative Agent, provide the Lenders with (x) title and extended coverage
insurance covering such real property in an amount at least equal to the
purchase price of such real property (or such other amount as shall be
reasonably specified by the Administrative Agent) as well as a current ALTA
survey thereof, together with a surveyor's certificate and (y) any consents or
estoppels reasonably deemed necessary or advisable by the Administrative Agent
in connection with such Mortgage, each of the foregoing in form and substance
reasonably satisfactory to the Administrative Agent and (iii) if requested by
the Administrative Agent, deliver to the Administrative Agent legal opinions
relating to the matters described above, which opinions shall be in form and
substance, and from counsel, reasonably satisfactory to the Administrative
Agent.

            (c) With respect to any new Subsidiary (other than an Excluded
Foreign Subsidiary) created or acquired after the Closing Date by any Group
Member (which, for the purposes of this paragraph (c), shall include any
existing Subsidiary that ceases to be an Excluded Foreign Subsidiary), promptly
(i) execute and deliver to the Administrative Agent such amendments to the
Guarantee and Collateral Agreement as the Administrative Agent deems necessary
or advisable to grant to the Administrative Agent, for the benefit of the
Lenders, a perfected first priority security interest in the Capital Stock of
such new Subsidiary that is owned by any Group Member, (ii) deliver to the
Administrative Agent the certificates representing such Capital Stock, together
with undated stock powers, in blank, executed and delivered by a duly authorized
officer of the relevant Group Member, (iii) cause such new Subsidiary (A) to
become a party to the Guarantee and Collateral Agreement, (B) to take such
actions necessary or advisable to grant to the Administrative Agent for the
benefit of the Lenders a perfected first priority security interest in the
Collateral described in the Guarantee and Collateral Agreement with respect to
such new Subsidiary, including the filing of Uniform Commercial Code financing
statements in such jurisdictions as may be required by the Guarantee and
Collateral Agreement or by law or as may be requested by the Administrative
Agent and (C) to deliver to the Administrative Agent a certificate of such
Subsidiary, substantially in the form of Exhibit B,

                                       39
<PAGE>

with appropriate insertions and attachments, and (iv) if requested by the
Administrative Agent, deliver to the Administrative Agent legal opinions
relating to the matters described above, which opinions shall be in form and
substance, and from counsel, reasonably satisfactory to the Administrative
Agent.

            (d) With respect to any new Excluded Foreign Subsidiary created or
acquired after the Closing Date by any Group Member (other than by any Group
Member that is an Excluded Foreign Subsidiary), promptly (i) execute and deliver
to the Administrative Agent such amendments to the Guarantee and Collateral
Agreement as the Administrative Agent deems necessary or advisable to grant to
the Administrative Agent, for the benefit of the Lenders, a perfected first
priority security interest in the Capital Stock of such new Subsidiary that is
owned by any such Group Member (provided that in no event shall more than 66% of
the total outstanding Capital Stock of any such new Subsidiary be required to be
so pledged), (ii) deliver to the Administrative Agent the certificates
representing such Capital Stock, together with undated stock powers, in blank,
executed and delivered by a duly authorized officer of the relevant Group Member
and take such other action as may be necessary or, in the opinion of the
Administrative Agent, desirable to perfect the Administrative Agent's security
interest therein, and (iii) if requested by the Administrative Agent, deliver to
the Administrative Agent legal opinions relating to the matters described above,
which opinions shall be in form and substance, and from counsel, reasonably
satisfactory to the Administrative Agent.

            7.10 Patriot Act Compliance. Provide such information and take such
actions as are reasonably required by the Administrative Agent or any Lender in
order to assist the Administrative Agent and Lenders with compliance with the
USA Patriot Act, Title III of Pub. L. 107-56, signed into law October 26, 2001,
as amended.

            7.11 Payment of Fees and Expenses. Pay to the Administrative Agent
the fees, costs and other expenses in the amounts and on the dates previously
agreed to in writing by the Borrowers and the Administrative Agent.

            7.12 Landlord Waivers; Bailee Letters. Use commercially reasonable
efforts to obtain a landlord's agreement or bailee letter, as applicable, from
the lessor of each leased property or bailee with respect to any warehouse,
processor or converted facility or other location where Collateral having a fair
market value equal to at least $100,000 is stored or located, which agreement or
letter shall be reasonably satisfactory in form and substance to the
Administrative Agent.

            7.13 Cash Management Systems. The Borrowers shall, and shall cause
each other Loan Party to, enter into Control Agreements with respect to each
deposit account maintained by any Borrower or any Subsidiary (other than any
payroll account so long as such payroll account is a zero balance account) as of
or after the Closing Date. Each such deposit account control agreement shall be
in form and substance satisfactory to the Administrative Agent.

            7.14 Further Assurances. From time to time execute and deliver, or
cause to be executed and delivered, such additional instruments, certificates or
documents, and take all such actions, as the Administrative Agent may reasonably
request for the purposes of implementing or

                                       40
<PAGE>

effectuating the provisions of this Agreement and the other Loan Documents, or
of more fully perfecting or renewing the rights of the Administrative Agent and
the Lenders with respect to the Collateral (or with respect to any additions
thereto or replacements or proceeds thereof or with respect to any other
property or assets hereafter acquired by any Borrower or any Subsidiary which
may be deemed to be part of the Collateral) pursuant hereto or thereto. Upon the
exercise by the Administrative Agent or any Lender of any power, right,
privilege or remedy pursuant to this Agreement or the other Loan Documents which
requires any consent, approval, recording qualification or authorization of any
Governmental Authority, each applicable Borrower will execute and deliver, or
will cause the execution and delivery of, all applications, certifications,
instruments and other documents and papers that the Administrative Agent or such
Lenders may be required to obtain from such Borrower or any of its Subsidiaries
for such governmental consent, approval, recording, qualification or
authorization.

            7.15 Certain Subsidiaries. Ryker Dental of Kentucky, Inc. shall not
(i) hold any assets, (ii) have any active business operations or (iii) have any
debt or other liabilities (other than in relation to the Ryker's Worker's
Compensation Claim).

            7.16 Salaries. All salaries, bonuses, consultant fees or other
compensation to any director, officer or consultant or any member of their
families shall be reasonably consistent with the guidelines set forth by the
applicable Borrower's compensation committee.

            7.17 Mortgages, etc. If requested by the Administrative Agent, the
Administrative Agent shall have received a Mortgage with respect to each
Mortgaged Property, executed and delivered by a duly authorized officer of each
party thereto in accordance with the requirements set forth below and in any
event satisfactory to the Administrative Agent; provided, however, to the extent
the Prescott Sale/Leaseback has not occurred on or prior to sixty (60) days
following the Closing Date, the Administrative Agent shall have received a
Mortgage on the Prescott Facility on or prior to sixty (60) days following the
Closing Date, or such other time period as may be consented to by the
Administrative Agent in its sole discretion.

                  (i) If requested by the Administrative Agent, the
            Administrative Agent shall have received, and the title insurance
            company issuing the policy referred to in clause (iii) below (the
            "Title Insurance Company") shall have received, maps or plats of an
            as-built survey of the sites of the Mortgaged Properties certified
            to the Administrative Agent and the Title Insurance Company in a
            manner satisfactory to them, dated a date satisfactory to the
            Administrative Agent and the Title Insurance Company, by an
            independent professional licensed land surveyor satisfactory to the
            Administrative Agent and the Title Insurance Company, which maps or
            plats and the surveys on which they are based shall be made in
            accordance with the Minimum Standard Detail Requirements for Land
            Title Surveys jointly established and adopted by the American Land
            Title Association and the American Congress on Surveying and Mapping
            in 1992, and, without limiting the generality of the foregoing,
            there shall be surveyed and shown on such maps, plats or surveys the
            following: (A) the locations on such sites of all the buildings,
            structures and other improvements and the established building
            setback lines; (B) the lines of streets abutting the sites and width
            thereof; (C) all access and other easements appurtenant to the
            sites; (D) all roadways,

                                       41
<PAGE>

            paths, driveways, easements, encroachments and overhanging
            projections and similar encumbrances affecting the site, whether
            recorded, apparent from a physical inspection of the sites or
            otherwise known to the surveyor; (E) any encroachments on any
            adjoining property by the building structures and improvements on
            the sites; (F) if the site is described as being on a filed map, a
            legend relating the survey to said map; and (G) the flood zone
            designations, if any, in which the Mortgaged Properties are located.

                  (ii) The Administrative Agent shall have received in respect
            of each Mortgaged Property a mortgagee's title insurance policy (or
            policies) or marked up unconditional binder for such insurance. Each
            such policy shall (A) be in an amount satisfactory to the
            Administrative Agent; (B) be issued at ordinary rates; (C) insure
            that the Mortgage insured thereby creates a valid first Lien on such
            Mortgaged Property free and clear of all defects and encumbrances,
            except as disclosed therein; (D) name the Administrative Agent for
            the benefit of the Lenders as the insured thereunder; (E) be in the
            form of ALTA Loan Policy - 1992 extended coverage (or equivalent
            policies); (F) contain such endorsements and affirmative coverage as
            the Administrative Agent may reasonably request; and (G) be issued
            by title companies satisfactory to the Administrative Agent
            (including any such title companies acting as co-insurers or
            reinsurers, at the option of the Administrative Agent). The
            Administrative Agent shall have received evidence satisfactory to it
            that all premiums in respect of each such policy, all charges for
            mortgage recording tax, and all related expenses, if any, have been
            paid.

                  (iii) If requested by the Administrative Agent, the
            Administrative Agent shall have received (A) a policy of flood
            insurance that (1) covers any parcel of improved real property that
            is encumbered by any Mortgage, (2) is written in an amount not less
            than the outstanding principal amount of the indebtedness secured by
            such Mortgage that is reasonably allocable to such real property or
            the maximum limit of coverage made available with respect to the
            particular type of property under the National Flood Insurance Act
            of 1968, whichever is less, and (3) has a term ending not later than
            the maturity of the Indebtedness secured by such Mortgage and (B)
            confirmation that the applicable Borrower has received the notice
            required pursuant to Section 208(e)(3) of Regulation H of the Board.

                  (iv) The Administrative Agent shall have received a copy of
            all recorded documents referred to, or listed as exceptions to title
            in, the title policy or policies referred to in clause (iii) above
            and a copy of all other material documents affecting the Mortgaged
            Properties.

                                       42
<PAGE>

                                   SECTION 8.

                               NEGATIVE COVENANTS

            The Borrowers hereby jointly and severally agree that, so long as
the Commitments remain in effect, or any Loans or other amount is owing to any
Lender or the Administrative Agent hereunder, each Borrower, without the
Administrative Agent's prior written consent, shall not, and shall not permit
any of its Subsidiaries to, directly or indirectly:

            8.1 Financial Condition Covenants. Breach or fail to comply with any
of the following financial covenants, each of which shall be calculated in
accordance with GAAP consistently applied:

            (a) With respect to the Nutraceuticals Business on an individual
      basis:

                  (i) Minimum LTM EBITDA. The Nutraceuticals Business shall
            have, at the end of each fiscal month set forth below, EBITDA as of
            the last day of such fiscal month for the 12 month period then ended
            of not less than the amount set forth below opposite such fiscal
            month:

<TABLE>
<CAPTION>
Fiscal Month Ending    Minimum LTM EBITDA
-------------------    ------------------
<S>                    <C>
April 30, 2006            $  4,150,000
May 31, 2006              $  4,500,000
June 30, 2006             $  4,800,000
July 31, 2006             $  3,650,000
August 31, 2006           $  3,100,000
September 30, 2006        $  3,100,000
October 31, 2006          $  4,350,000
November 30, 2006         $  5,550,000
December 31, 2006         $  6,900,000
January 30, 2007          $  7,750,000
February 28, 2007         $  8,350,000
March 31, 2007            $  8,800,000
April 30, 2007            $  8,850,000
</TABLE>

                                       43
<PAGE>

<TABLE>
<S>                       <C>
May 31, 2007              $   8,900,000
June 30, 2007             $   9,050,000
July 31, 2007             $   8,100,000
August 31, 2007           $   8,650,000
September 30, 2007        $   9,250,000
October 31, 2007          $   9,300,000
November 30, 2007         $   9,850,000
December 31, 2007         $  10,500,000
January 30, 2008          $  10,300,000
February 29, 2008         $  10,900,000
March 31, 2008            $  11,500,000
</TABLE>

            (b) With respect to the Borrowers operations are a whole:

                  (i) Minimum LTM EBITDA. The Borrowers shall have, at the end
            of each fiscal month set forth below, EBITDA as of the last day of
            such fiscal month for the 12 month period then ended of not less
            than the amount set forth below opposite such fiscal month:

<TABLE>
<CAPTION>
Fiscal Month Ending    Minimum LTM EBITDA
-------------------    ------------------
<S>                    <C>
April 30, 2006          $  (17,650,000)
May 31, 2006            $  (17,950,000)
June 30, 2006           $  (18,300,000)
July 31, 2006           $  (21,900,000)
August 31, 2006         $  (22,200,000)
September 30, 2006      $  (21,500,000)
October 31, 2006        $  (18,800,000)
November 30, 2006       $  (15,900,000)
</TABLE>

                                       44
<PAGE>

<TABLE>
<S>                     <C>
December 31, 2006       $  (12,350,000)
January 30, 2007        $  (10,550,000)
February 28, 2007       $   (8,500,000)
March 31, 2007          $   (6,450,000)
April 30, 2007          $   (4,550,000)
May 31, 2007            $   (3,200,000)
June 30, 2007           $   (1,250,000)
July 31, 2007           $   (1,450,000)
August 31, 2007         $      450,000
September 30, 2007      $    1,850,000
October 31, 2007        $    2,650,000
November 30, 2007       $    3,850,000
December 31, 2007       $    5,050,000
January 30, 2008        $    5,450,000
February 29, 2008       $    6,400,000
March 31, 2008          $    7,350,000
</Table>

                  (ii) Minimum Cash. The Borrowers shall have, at the end of
            each fiscal month set forth below, unrestricted average balances of
            cash and Cash Equivalents and Restricted Cash for such fiscal month
            in an amount not less than the amount set forth below opposite such
            fiscal month:

<TABLE>
<CAPTION>
Fiscal Month Ending    Minimum Cash
-------------------    ------------
<S>                    <C>
April 30, 2006         $ 11,800,000
May 31, 2006           $  9,650,000
June 30, 2006          $  7,500,000
July 31, 2006          $  8,500,000
</TABLE>

                                       45
<PAGE>

<TABLE>
<S>                    <C>
August 31, 2006        $  6,750,000
September 30, 2006     $  5,200,000
October 31, 2006       $  5,800,000
November 30, 2006      $  4,300,000
December 31, 2006      $  3,100,000
January 30, 2007       $  4,400,000
February 28, 2007      $  3,100,000
March 31, 2007         $  2,250,000
April 30, 2007         $  4,150,000
May 31, 2007           $  2,700,000
June 30, 2007          $  1,650,000
July 31, 2007          $  1,800,000
August 31, 2007        $  1,250,000
September 30, 2007     $    950,000
October 31, 2007       $  1,850,000
November 30, 2007      $  1,450,000
December 31, 2007      $  1,300,000
January 30, 2008       $  2,550,000
February 29, 2008      $  2,000,000
March 31, 2008         $  1,800,000
</TABLE>

                  ; provided, however, notwithstanding the table set forth
above, for each fiscal month prior to and including the fiscal month during
which the Prescott Sale/Leaseback is consummated, the Borrowers shall have
unrestricted average daily balances of cash and Cash Equivalents and Restricted
Cash for such fiscal month in an amount not less than the following (it being
understood that compliance with the minimum cash covenant set forth in this
Section

                                       46
<PAGE>

8.1(b)(ii) shall be calculated in accordance with the table set forth above
commencing with the first full fiscal month following the date on which the
Prescott Sale/Leaseback is consummated):

                  (A) For the month ending April 30, 2006 an amount equal to
            $9,800,000;

                  (B) for the month ending May 31, 2006 an amount equal to
            $7,650,000;

                  (C) for the month ending June 30, 2006 an amount equal to
            $5,500,000;

                  (D) for the month ending July 31, 2006 an amount equal to
            $6,500,000; and

                  (E) for the month ending August 31, 2006 an amount equal to
            $4,750,000.

            8.2 Indebtedness. Create, issue, incur, assume, become liable in
respect of or suffer to exist any Indebtedness, except:

            (a) Indebtedness of any Loan Party pursuant to any Loan Document;

            (b) Indebtedness (i) of any Borrower to any Subsidiary Guarantor and
      (ii) of any Subsidiary Guarantor to any Borrower or any other Subsidiary
      Guarantor;

            (c) Guarantee Obligations incurred in the ordinary course of
      business by any Borrower or any Subsidiary in respect of obligations of
      any other Borrower;

            (d) Indebtedness outstanding on the date hereof and listed on
      Schedule 8.2(d) and any refinancings, refundings, renewals or extensions
      thereof (without increasing, or shortening the maturity of, the principal
      amount thereof);

            (e) Indebtedness (including, without limitation, Capital Lease
      Obligations) secured by Liens permitted by Section 8.3(f) in an aggregate
      principal amount not to exceed $250,000 at any one time outstanding;

            (f) Indebtedness evidenced by the IDA Documents; and

            (g) Hedge Agreements permitted under Section 8.12.

            8.3 Liens. Create, incur, assume or suffer to exist any Lien upon
any of its property, whether now owned or hereafter acquired, except for:

            (a) Liens for taxes not yet due or that are being contested in good
      faith by appropriate proceedings; provided that adequate reserves with
      respect thereto are maintained on the books of any Borrower or any
      Subsidiary in conformity with GAAP;

                                       47
<PAGE>

            (b) carriers', warehousemen's, mechanics', materialmen's,
      repairmen's or other like Liens arising in the ordinary course of business
      that are not overdue for a period of more than 30 days or that are being
      contested in good faith by appropriate proceedings;

            (c) pledges or deposits in connection with workers' compensation,
      unemployment insurance and other social security legislation;

            (d) easements, rights-of-way, restrictions and other similar
      encumbrances incurred in the ordinary course of business that, in the
      aggregate, are not substantial in amount and that do not in any case
      materially detract from the value of the property subject thereto or
      materially interfere with the ordinary conduct of the business of any
      Borrower or any Subsidiary;

            (e) Liens in existence on the date hereof listed on Schedule 8.3(f),
      securing Indebtedness permitted by Section 8.2(d); provided that no such
      Lien is spread to cover any additional property after the Closing Date and
      that the amount of Indebtedness secured thereby is not increased;

            (f) Liens securing Indebtedness of any Borrower or any other
      Subsidiary incurred pursuant to Section 8.2(e) to finance the acquisition
      of fixed or capital assets; provided that (i) such Liens shall be created
      substantially simultaneously with the acquisition of such fixed or capital
      assets, (ii) such Liens do not at any time encumber any property other
      than the property financed by such Indebtedness and (iii) the amount of
      Indebtedness secured thereby is not increased;

            (g) Liens created pursuant to the Security Documents; and

            (h) any interest or title of a lessor under any lease entered into
      by any Borrower or any other Subsidiary in the ordinary course of its
      business and covering only the assets so leased.

            8.4 Fundamental Changes. Enter into any acquisition, merger,
consolidation or amalgamation, or liquidate, wind up or dissolve itself (or
suffer any liquidation or dissolution), or Dispose of, all or substantially all
of its property or business, except that:

            (a) any Subsidiary of any Borrower may be merged or consolidated
      with or into any other Borrower (provided that such Borrower shall be the
      continuing or surviving corporation) or with or into any Wholly Owned
      Subsidiary Guarantor (provided that the Wholly Owned Subsidiary Guarantor
      shall be the continuing or surviving corporation); and

            (b) any Subsidiary of any Borrower may Dispose of any or all of its
      assets (upon voluntary liquidation or otherwise) to such Borrower or any
      Wholly Owned Subsidiary Guarantor;

            (c) any Subsidiary may merge with another Person to effect a
      transaction permitted under Section 8.8; and

                                       48
<PAGE>

            (d) transactions permitted under Section 8.5 shall be permitted.

            8.5 Disposition of Property. Dispose of any of Property, whether now
owned or hereafter acquired, or, in the case of any Subsidiary, issue or sell
any shares of such Subsidiary's Capital Stock to any Person, except:

            (a) the Disposition of obsolete or worn out property in the ordinary
      course of business;

            (b) the sale of inventory in the ordinary course of business;

            (c) Dispositions permitted by Section 8.4(b);

            (d) the sale or issuance of any Subsidiary's Capital Stock to any
      Borrower or any Wholly Owned Subsidiary Guarantor;

            (e) the Dispositions permitted by Section 8.11; and

            (f) the Disposition of the Business of Zila Swab Technologies, Inc.
      subject to terms and documentation reasonably satisfactory to the
      Administrative Agent.

            8.6 Restricted Payments. Declare or pay any dividend (other than
dividends payable solely in common stock of the Person making such dividend) on,
or make any payment on account of, or set apart assets for a sinking or other
analogous fund for, the purchase, redemption, defeasance, retirement or other
acquisition of, any Capital Stock of any Group Member, whether now or hereafter
outstanding, or make any other distribution in respect thereof, either directly
or indirectly, whether in cash or property or in obligations of any Borrower or
any Subsidiary (collectively, "Restricted Payments"), except that any Subsidiary
may make Restricted Payments to any Borrower or any Wholly Owned Subsidiary
Guarantor.

            8.7 Capital Expenditures. Make or commit to make any Capital
Expenditure, except the aggregate Capital Expenditures of the Borrowers and
their respective Subsidiaries in the ordinary course of business not exceeding
$2,500,000 per annum; provided, that (i) up to $750,000 of any such amount
referred to above, if not so expended in the fiscal year for which it is
permitted, may be carried over for expenditure in the next succeeding fiscal
year and (ii) Capital Expenditures made pursuant to this section during any
fiscal year shall be deemed made, first, in respect of amounts permitted for
such fiscal year as provided above and, second, in respect of amounts carried
over from the prior fiscal year pursuant to subclause (i) above.

            8.8 Investments. Make any advance, loan, extension of credit (by way
of guaranty or otherwise) or capital contribution to, or acquire any assets, or
purchase any Capital Stock, bonds, notes, debentures or other debt securities
of, or any assets constituting a business unit of, or make any other investment
in, any Person (all of the foregoing, "Investments"), except:

            (a) extensions of trade credit in the ordinary course of business;

            (b) Investments in Cash Equivalents;

                                       49
<PAGE>

            (c) Guarantee Obligations permitted by Section 8.2;

            (d) loans and advances to employees of any Group Member of the
      Borrowers in the ordinary course of business (including for travel,
      entertainment and relocation expenses) in an aggregate amount for all
      Group Members not to exceed $50,000 at any one time outstanding; and

            (e) intercompany Investments by any Group Member in any Borrower or
      any Person that, prior to such Investment, is a Wholly Owned Subsidiary
      Guarantor.

            8.9 Optional Payments and Modifications of Certain Debt Instruments.
Make or offer to make any optional or voluntary payment, prepayment, repurchase
or redemption of, or otherwise optionally or voluntarily defease or segregate
funds with respect to, any Indebtedness evidenced by the IDA Documents pursuant
to Section 8.2(f); provided, however, the Borrowers may prepay such Indebtedness
so long as (i) such prepayment is in conjunction with the definitive
documentation in respect of the Prescott Sale/Leaseback and (ii) the Borrowers
apply towards the prepayment of the Term Loan an amount equal to 50% of the
aggregate Net Cash Proceeds received from the Prescott Sale/Leaseback in
accordance with Section 4.2(b), in each case, satisfactory to the Administrative
Agent

            8.10 Transactions with Affiliates. Enter into any transaction,
including any purchase, sale, lease or exchange of property, the rendering of
any service or the payment of any management, advisory or similar fees, with any
other Group Member, any Affiliate, any member of the Scientific Advisory Board,
or any member of the board of directors, employee or management of any Group
Member except for such transactions which are (i) otherwise permitted under this
Agreement, (ii) in the ordinary course of business of the relevant Group Member,
and (iii) upon fair and reasonable terms no less favorable to the relevant Group
Member than it would obtain in a comparable arm's length transaction with a
Person that is not an Affiliate.

            8.11 Sales and Leasebacks. Except for the Prescott Facility, enter
into any arrangement with any Person providing for the leasing by any Group
Member of real or personal property that has been or is to be sold or
transferred by such Group Member to such Person or to any other Person to whom
funds have been or are to be advanced by such Person on the security of such
property or rental obligations of such Group Member.

            8.12 Hedge Agreements. Enter into any Hedge Agreement, except (a)
Hedge Agreements entered into to hedge or mitigate risks to which any Borrower
or any Subsidiary has actual exposure (other than those in respect of Capital
Stock) and (b) Hedge Agreements entered into in order to effectively cap, collar
or exchange interest rates (from fixed to floating rates, from one floating rate
to another floating rate or otherwise) with respect to any interest-bearing
liability or investment of any Borrower or any Subsidiary.

            8.13 Changes in Fiscal Periods. Permit the fiscal year of the
Borrowers to end on a day other than July 31 or change the Borrowers method of
determining fiscal quarters.

            8.14 Negative Pledge Clauses. Enter into or suffer to exist or
become effective any agreement that prohibits, limits or imposes any condition
upon the ability of any Group

                                       50
<PAGE>

Member to create, incur, assume or suffer to exist any Lien upon any of its
property or revenues, whether now owned or hereafter acquired, to secure its
obligations under the Loan Documents or any refinancing thereof other than (a)
this Agreement and the other Loan Documents and (b) any agreements governing any
purchase money Liens or Capital Lease Obligations otherwise permitted hereby (in
which case, any prohibition or limitation shall only be effective against the
assets financed thereby).

            8.15 Clauses Restricting Subsidiary Distributions. Enter into or
suffer to exist or become effective any consensual encumbrance or restriction on
the ability of any Subsidiary of any Borrower to (a) make Restricted Payments in
respect of any Capital Stock of such Subsidiary held by, or pay any Indebtedness
owed to, such Borrower or any other Subsidiary of such Borrower, (b) make loans
or advances to, or other Investments in, any Borrower or any other Subsidiary of
such Borrower or (c) transfer any of its assets to any Borrower or any other
Subsidiary of such Borrower, except for such encumbrances or restrictions
existing under or by reason of (i) any restrictions existing under the Loan
Documents and (ii) any restrictions with respect to a Subsidiary imposed
pursuant to an agreement that has been entered into in connection with the
Disposition of all or substantially all of the Capital Stock or assets of such
Subsidiary.

            8.16 Lines of Business. Enter into any business, either directly or
through any Subsidiary, except for those businesses in which any Borrower and
any Subsidiary is engaged on the date of this Agreement or that are reasonably
related thereto.

            8.17 Cancellation of Indebtedness. Cancel any claim or debt owing to
any Borrower or any Subsidiary, except for reasonable consideration negotiated
on an arm's length basis and in the ordinary course of its business consistent
with past practices.

            8.18 Additional Deposit Accounts. Create or replace any deposit
account listed on Schedules 5.20(a) and (b) (other than Excluded Accounts)
unless (i) the Administrative Agent shall have consented in writing in advance
to the addition or replacement of such account with the relevant bank, (ii)
prior to the time of the opening of any such new account, the Administrative
Agent, the applicable Loan Party and such bank shall have executed and delivered
to the Administrative Agent a tri-party blocked account agreement, in form and
substance satisfactory to Administrative Agent, and (iii) prior to the time of
the opening of such new account, the Loan Parties shall have delivered to the
Administrative Agent and updated Schedules 5.20(a) and (b) (together with any
amendments or supplements to the schedules to the Guarantee and Collateral
Agreement) reflecting the additional or subtracted account.

            8.19 Amendments to Material Contracts. Amend, supplement or
otherwise modify the terms and conditions of any Material Contract listed on
Schedule 8.20 except for any such amendment, supplement or modification that (i)
becomes effective after the Closing Date and (ii) could not reasonably be
expected to have a Material Adverse Effect.

            8.20 Holdings. Holdings shall not engage in any trade or business,
or own or hold any assets (other than its interest in the Borrowers and its
Subsidiaries and de minimus assets), or incur any Indebtedness or other
liabilities other than under the Loan Documents and the Warrant Documents.

                                       51
<PAGE>

            8.21 Accounts. Setoff, claim or dispute Accounts or make any
agreement with any Account Debtor for any extension of time for the payment
thereof, any compromise or settlement for less than the full amount thereof, any
release of any Account Debtor from liability therefor, or any deduction
therefrom except a discount or allowance allowed by any Borrower or any
Subsidiary in the ordinary course of its business for prompt payment and
disclosed to the Administrative Agent.

            8.22 UBS Account. Until such time the Borrowers deliver a Control
Agreement, in form and substance reasonably satisfactory to the Administrative
Agent, duly executed by the applicable Borrower(s), the Administrative Agent and
UBS Financial Services, Inc., with respect to the UBS Account, the Borrowers
will not at any time maintain any funds in the UBS Account.

                                   SECTION 9.

                                EVENTS OF DEFAULT

            If any of the following events (each an "Event of Default") shall
occur and be continuing:

            (a) (i) the Borrowers shall fail to pay any principal of the Loans
      when due in accordance with the terms hereof; or (ii) the Borrowers shall
      fail to pay any interest on the Loans, or any other amount payable
      hereunder or under any other Loan Document within five days after any such
      interest or other amount becomes due in accordance with the terms hereof;
      or

            (b) any representation or warranty made or deemed made by any Loan
      Party herein or in any other Loan Document or that is contained in any
      certificate, document or financial or other statement furnished by it at
      any time under or in connection with this Agreement or any such other Loan
      Document shall prove to have been inaccurate in any material respect on or
      as of the date made or deemed made; or

            (c) (i) any Loan Party shall default in the observance or
      performance of any agreement contained in clause (i) or (ii) of Section
      7.4(a) (with respect to the Borrowers only), Section 7.7(a) or Section 8
      of this Agreement or Sections 5.5 and 5.7(b) of the Guarantee and
      Collateral Agreement or (ii) an "Event of Default" under and as defined in
      any Mortgage shall have occurred and be continuing; or

            (d) any Loan Party shall default in the observance or performance of
      any other agreement contained in this Agreement or any other Loan Document
      (other than as provided in paragraphs (a) through (c) of this Section),
      and such default shall continue unremedied for a period of 30 days after
      notice to the Borrower Representative from the Administrative Agent; or

            (e) any Group Member (i) defaults in making any payment of any
      principal of any Indebtedness (including any Guarantee Obligation, but
      excluding the Loans) on the scheduled or original due date with respect
      thereto; or (ii) defaults in making any payment of any interest on any
      such Indebtedness beyond the period of grace, if any,

                                       52
<PAGE>

      provided in the instrument or agreement under which such Indebtedness was
      created; or (iii) defaults in the observance or performance of any other
      agreement or condition relating to any such Indebtedness or contained in
      any instrument or agreement evidencing, securing or relating thereto, or
      any other event shall occur or condition exist, the effect of which
      default or other event or condition is to cause, or to permit the holder
      or beneficiary of such Indebtedness (or a trustee or agent on behalf of
      such holder or beneficiary) to cause, with the giving of notice if
      required, such Indebtedness to become due prior to its stated maturity or
      to become subject to a mandatory offer to purchase by the obligor
      thereunder or (in the case of any such Indebtedness constituting a
      Guarantee Obligation) to become payable; provided, that a default, event
      or condition described in clause (i), (ii) or (iii) of this paragraph (e)
      shall not at any time constitute an Event of Default unless, at such time,
      one or more defaults, events or conditions of the type described in
      clauses (i), (ii) and (iii) of this paragraph (e) shall have occurred and
      be continuing with respect to Indebtedness the outstanding principal
      amount of which exceeds in the aggregate $500,000; or

            (f) (i) any Group Member shall commence any case, proceeding or
      other action (A) under any existing or future law of any jurisdiction,
      domestic or foreign, relating to bankruptcy, insolvency, reorganization or
      relief of debtors, seeking to have an order for relief entered with
      respect to it, or seeking to adjudicate it a bankrupt or insolvent, or
      seeking reorganization, arrangement, adjustment, winding-up, liquidation,
      dissolution, composition or other relief with respect to it or its debts,
      or (B) seeking appointment of a receiver, trustee, custodian, conservator
      or other similar official for it or for all or any substantial part of its
      assets, or any Group Member shall make a general assignment for the
      benefit of its creditors; or (ii) there shall be commenced against any
      Group Member any case, proceeding or other action of a nature referred to
      in clause (i) above that (A) results in the entry of an order for relief
      or any such adjudication or appointment or (B) remains undismissed,
      undischarged or unbonded for a period of 60 days; or (iii) there shall be
      commenced against any Group Member any case, proceeding or other action
      seeking issuance of a warrant of attachment, execution, distraint or
      similar process against all or any substantial part of its assets that
      results in the entry of an order for any such relief that shall not have
      been vacated, discharged, stayed or bonded pending appeal within 60 days
      from the entry thereof; or (iv) any Group Member shall take any action in
      furtherance of, or indicating its consent to, approval of, or acquiescence
      in, any of the acts set forth in clause (i), (ii), or (iii) above; or (v)
      any Group Member shall generally not, or shall be unable to, or shall
      admit in writing its inability to, pay its debts as they become due; or

            (g) (i) any Person shall engage in any "prohibited transaction" (as
      defined in Section 406 of ERISA or Section 4975 of the Code) involving any
      Plan, (ii) any "accumulated funding deficiency" (as defined in Section 302
      of ERISA), whether or not waived, shall exist with respect to any Plan or
      any Lien in favor of the PBGC or a Plan shall arise on the assets of any
      Group Member or any Commonly Controlled Entity, (iii) a Reportable Event
      shall occur with respect to, or proceedings shall commence to have a
      trustee appointed, or a trustee shall be appointed, to administer or to
      terminate, any Single Employer Plan, which Reportable Event or
      commencement of proceedings or appointment of a trustee is, in the
      reasonable opinion of the Required Lenders, likely to

                                       53
<PAGE>

      result in the termination of such Plan for purposes of Title IV of ERISA,
      (iv) any Single Employer Plan shall terminate for purposes of Title IV of
      ERISA, (v) any Group Member or any Commonly Controlled Entity shall, or in
      the reasonable opinion of the Required Lenders is likely to, incur any
      liability in connection with a withdrawal from, or the Insolvency or
      Reorganization of, a Multiemployer Plan or (vi) any other event or
      condition shall occur or exist with respect to a Plan; and in each case in
      clauses (i) through (vi) above, such event or condition, together with all
      other such events or conditions, if any, could, in the sole judgment of
      the Required Lenders, reasonably be expected to have a Material Adverse
      Effect; or

            (h) one or more judgments or decrees shall be entered against any
      Group Member involving in the aggregate a liability (not paid or fully
      covered by insurance as to which the relevant insurance company has
      acknowledged coverage) of $500,000 or more, and all such judgments or
      decrees shall not have been vacated, discharged, stayed or bonded pending
      appeal within 30 days from the entry thereof; or

            (i) any of the Security Documents shall cease, for any reason, to be
      in full force and effect, or any Loan Party or any Affiliate of any Loan
      Party shall so assert, or any Lien created by any of the Security
      Documents shall cease to be enforceable and of the same effect and
      priority purported to be created thereby; or

            (j) the guarantee contained in Section 2 of the Guarantee and
      Collateral Agreement shall cease, for any reason, to be in full force and
      effect or any Loan Party or any Affiliate of any Loan Party shall so
      assert; or

            (k) any Loan Party shall challenge the enforceability of any Loan
      Document or shall assert in writing, or engage in any action or inaction
      based on any such assertion, that any provision of any of the Loan
      Documents has ceased to be or otherwise is not valid, binding and
      enforceable in accordance with its terms; or

            (l) any material provision of any Loan Document for any reason
      ceases to be valid, binding and enforceable in accordance with its terms
      and such event would reasonably be expected to impair or adversely affect
      the Administrative Agent's ability to realize upon the Collateral; or

            (m) any event, change or condition that has caused, or could
      reasonably be expected to cause, a Material Adverse Effect;

            (n) a Change of Control shall occur; or

            (o) any obligations of the Subsidiary Guarantors under the Guarantee
      and Collateral Agreement shall cease to be valid or any Loan Party or any
      Affiliate of any Loan Party shall so assert and such event or assertion
      would reasonably be expected to impair or adversely affect the
      Administrative Agent's ability to realize upon the Collateral;

then, and in any such event, (A) if such event is an Event of Default specified
in clause (i) or (ii) of paragraph (f) above with respect to the Borrowers,
automatically the Commitments shall

                                       54
<PAGE>

immediately terminate and the Loans hereunder (with accrued interest thereon)
and all other amounts owing under this Agreement and the other Loan Documents
shall immediately become due and payable, and (B) if such event is any other
Event of Default with the consent of the Required Lenders, the Administrative
Agent may, or upon the request of the Required Lenders, the Administrative Agent
shall, by notice to the Borrower, declare the Loans hereunder (with accrued
interest thereon) and all other amounts owing under this Agreement and the other
Loan Documents to be due and payable forthwith, whereupon the same shall
immediately become due and payable. After all other obligations of the Borrowers
hereunder and under the other Loan Documents shall have been paid in full, the
balance, if any, in such cash collateral account shall be returned to the
Borrowers (or such other Person as may be lawfully entitled thereto). Except as
expressly provided above in this Section, presentment, demand, protest and all
other notices of any kind are hereby expressly waived by the Borrowers.

                                  SECTION 10.

                            THE ADMINISTRATIVE AGENT

            10.1 Appointment. Each Lender hereby irrevocably designates and
appoints the Administrative Agent as the agent of such Lender under this
Agreement and the other Loan Documents, and each such Lender irrevocably
authorizes the Administrative Agent, in such capacity, to take such action on
its behalf under the provisions of this Agreement and the other Loan Documents
and to exercise such powers and perform such duties as are expressly delegated
to the Administrative Agent by the terms of this Agreement and the other Loan
Documents, together with such other powers as are reasonably incidental thereto.
Notwithstanding any provision to the contrary elsewhere in this Agreement, the
Administrative Agent shall not have any duties or responsibilities, except those
expressly set forth herein, or any fiduciary relationship with any Lender, and
no implied covenants, functions, responsibilities, duties, obligations or
liabilities shall be read into this Agreement or any other Loan Document or
otherwise exist against the Administrative Agent.

            10.2 Delegation of Duties. The Administrative Agent may execute any
of its duties under this Agreement and the other Loan Documents by or through
agents or attorneys-in-fact and shall be entitled to advice of counsel
concerning all matters pertaining to such duties. The Administrative Agent shall
not be responsible for the negligence or misconduct of any agents or attorneys
in-fact selected by it with reasonable care.

            10.3 Exculpatory Provisions. Neither the Administrative Agent nor
any of its respective officers, directors, employees, agents, attorneys-in-fact
or affiliates shall be (i) liable for any action lawfully taken or omitted to be
taken by it or such Person under or in connection with this Agreement or any
other Loan Document (except to the extent that any of the foregoing are found by
a final and nonappealable decision of a court of competent jurisdiction to have
resulted from its or such Person's own gross negligence or willful misconduct)
or (ii) responsible in any manner to any of the Lenders for any recitals,
statements, representations or warranties made by any Loan Party or any officer
thereof contained in this Agreement or any other Loan Document or in any
certificate, report, statement or other document referred to or provided for in,
or received by the Administrative Agent under or in connection with, this
Agreement or any other Loan Document or for the value, validity, effectiveness,
genuineness, enforceability or

                                       55
<PAGE>

sufficiency of this Agreement or any other Loan Document or for any failure of
any Loan Party a party thereto to perform its obligations hereunder or
thereunder. The Administrative Agent shall not be under any obligation to any
Lender to ascertain or to inquire as to the observance or performance of any of
the agreements contained in, or conditions of, this Agreement or any other Loan
Document, or to inspect the properties, books or records of any Loan Party.

            10.4 Reliance by Administrative Agent. The Administrative Agent
shall be entitled to rely, and shall be fully protected in relying, upon any
instrument, writing, resolution, notice, consent, certificate, affidavit,
letter, telecopy, telex or teletype message, statement, order or other document
or conversation believed by it to be genuine and correct and to have been
signed, sent or made by the proper Person or Persons and upon advice and
statements of legal counsel (including counsel to the Borrowers), independent
accountants and other experts selected by the Administrative Agent. The
Administrative Agent may deem and treat the payee of any Note as the owner
thereof for all purposes unless a written notice of assignment, negotiation or
transfer thereof shall have been filed with the Administrative Agent. The
Administrative Agent shall be fully justified in failing or refusing to take any
action under this Agreement or any other Loan Document unless it shall first
receive such advice or concurrence of the Required Lenders (or, if so specified
by this Agreement, all Lenders) as it deems appropriate or it shall first be
indemnified to its satisfaction by the Lenders against any and all liability and
expense that may be incurred by it by reason of taking or continuing to take any
such action. The Administrative Agent shall in all cases be fully protected in
acting, or in refraining from acting, under this Agreement and the other Loan
Documents in accordance with a request of the Required Lenders (or, if so
specified by this Agreement, all Lenders), and such request and any action taken
or failure to act pursuant thereto shall be binding upon all the Lenders and all
future holders of the Loans.

            10.5 Notice of Default. The Administrative Agent shall not be deemed
to have knowledge or notice of the occurrence of any Default or Event of Default
hereunder unless the Administrative Agent has received notice from a Lender or
the Borrower Representative referring to this Agreement, describing such Default
or Event of Default and stating that such notice is a "notice of default". In
the event that the Administrative Agent receives such a notice, the
Administrative Agent shall give notice thereof to the Lenders. The
Administrative Agent shall take such action with respect to such Default or
Event of Default as shall be reasonably directed by the Required Lenders (or, if
so specified by this Agreement, all Lenders or any other instructing group of
Lenders specified by this Agreement); provided that unless and until the
Administrative Agent shall have received such directions, the Administrative
Agent may (but shall not be obligated to) take such action, or refrain from
taking such action, with respect to such Default or Event of Default as it shall
deem advisable in the best interests of the Lenders.

            10.6 Non-Reliance on the Administrative Agent and Other Lenders.
Each Lender expressly acknowledges that neither the Administrative Agent nor any
of its respective officers, directors, employees, agents, attorneys-in-fact or
affiliates have made any representations or warranties to it and that no act by
the Administrative Agent hereafter taken, including any review of the affairs of
a Loan Party or any affiliate of a Loan Party, shall be deemed to constitute any
representation or warranty by the Administrative Agent to any Lender. Each
Lender represents to the Administrative Agent that it has, independently and
without reliance upon the Administrative Agent or any other Lender, and based on
such documents and

                                       56
<PAGE>

information as it has deemed appropriate, made its own appraisal of and
investigation into the business, operations, property, financial and other
condition and creditworthiness of the Loan Parties and their affiliates and made
its own decision to make its portion of the Loans hereunder and enter into this
Agreement. Each Lender also represents that it will, independently and without
reliance upon the Administrative Agent or any other Lender, and based on such
documents and information as it shall deem appropriate at the time, continue to
make its own credit analysis, appraisals and decisions in taking or not taking
action under this Agreement and the other Loan Documents, and to make such
investigation as it deems necessary to inform itself as to the business,
operations, property, financial and other condition and creditworthiness of the
Loan Parties and their affiliates. Except for notices, reports and other
documents expressly required to be furnished to the Lenders by the
Administrative Agent hereunder, the Administrative Agent shall not have any duty
or responsibility to provide any Lender with any credit or other information
concerning the business, operations, property, condition (financial or
otherwise), prospects or creditworthiness of any Loan Party or any affiliate of
a Loan Party that may come into the possession of the Administrative Agent or
any of its officers, directors, employees, agents, attorneys-in-fact or
affiliates.

            10.7 Indemnification. The Lenders agree to indemnify the
Administrative Agent in its capacity as such (to the extent not reimbursed by
the Borrowers and without limiting the obligation of the Borrowers to do so),
ratably according to their respective Aggregate Exposure Percentages in effect
on the date on which indemnification is sought under this Section (or, if
indemnification is sought after the date upon which the Commitments shall have
terminated and the Loans shall have been paid in full, ratably in accordance
with such Aggregate Exposure Percentages immediately prior to such date), from
and against any and all liabilities, obligations, losses, damages, penalties,
actions, judgments, suits, costs, expenses or disbursements of any kind
whatsoever that may at any time (whether before or after the payment of the
Loans) be imposed on, incurred by or asserted against the Administrative Agent
in any way relating to or arising out of, the Commitments, this Agreement, any
of the other Loan Documents or any documents contemplated by or referred to
herein or therein or the transactions contemplated hereby or thereby or any
action taken or omitted by the Administrative Agent under or in connection with
any of the foregoing; provided that no Lender shall be liable for the payment of
any portion of such liabilities, obligations, losses, damages, penalties,
actions, judgments, suits, costs, expenses or disbursements that are found by a
final and nonappealable decision of a court of competent jurisdiction to have
resulted from the Administrative Agent's gross negligence or willful misconduct.
The agreements in this Section shall survive the payment of the Loans and all
other amounts payable hereunder.

            10.8 The Administrative Agent in Its Individual Capacity. The
Administrative Agent and its affiliates may make loans to, accept deposits from
and generally engage in any kind of business with any Loan Party as though the
Administrative Agent was not the Administrative Agent. With respect to its Loans
made or renewed by it, the Administrative Agent shall have the same rights and
powers under this Agreement and the other Loan Documents as any Lender and may
exercise the same as though it was not the Administrative Agent, and the terms
"Lender" and "Lenders" shall include the Administrative Agent in its individual
capacity.

                                       57
<PAGE>

            10.9 Successor Administrative Agent. The Administrative Agent may
resign as Administrative Agent upon 10 days' notice to the Lenders and the
Borrower Representative. If the Administrative Agent shall resign as
Administrative Agent under this Agreement and the other Loan Documents, then the
Required Lenders shall appoint from among the Lenders a successor agent for the
Lenders, which successor agent shall (unless an Event of Default under Section
9(a) or Section 9(f) with respect to the Borrowers shall have occurred and be
continuing) be subject to approval by the Borrowers (which approval shall not be
unreasonably withheld or delayed), whereupon such successor agent shall succeed
to the rights, powers and duties of the Administrative Agent, and the term
"Administrative Agent" shall mean such successor agent effective upon such
appointment and approval, and the former Administrative Agent's rights, powers
and duties as Administrative Agent shall be terminated, without any other or
further act or deed on the part of such former Administrative Agent or any of
the parties to this Agreement or any holders of the Loans. If no successor agent
has accepted appointment as Administrative Agent by the date that is 10 days
following a retiring Administrative Agent's notice of resignation, the retiring
Administrative Agent's resignation shall nevertheless thereupon become effective
and the Lenders shall assume and perform all of the duties of the Administrative
Agent hereunder until such time, if any, as the Required Lenders appoint a
successor agent as provided for above. After any retiring Administrative Agent's
resignation as Administrative Agent, the provisions of this Section 10 shall
inure to its benefit as to any actions taken or omitted to be taken by it while
it was Administrative Agent under this Agreement and the other Loan Documents.

            10.10 Agents Generally. Except as expressly set forth herein, the
Administrative Agent shall not have any duties or responsibilities hereunder in
its capacity as such.

                                   SECTION 11.

                                  MISCELLANEOUS

            11.1 Amendments and Waivers. Neither this Agreement, any other Loan
Document, nor any terms hereof or thereof may be amended, supplemented or
modified except in accordance with the provisions of this Section 11.1. The
Required Lenders and each Loan Party to the relevant Loan Document may, or, with
the written consent of the Required Lenders, the Administrative Agent and each
Loan Party to the relevant Loan Document may, from time to time, (a) enter into
written amendments, supplements or modifications hereto and to the other Loan
Documents for the purpose of adding any provisions to this Agreement or the
other Loan Documents or changing in any manner the rights of the Lenders or of
the Loan Parties hereunder or thereunder or (b) waive, on such terms and
conditions as the Required Lenders or the Administrative Agent, as the case may
be, may specify in such instrument, any of the requirements of this Agreement or
the other Loan Documents or any Default or Event of Default and its
consequences; provided, however, that no such waiver and no such amendment,
supplement or modification shall (i) forgive the principal amount or extend the
final scheduled date of maturity of the Loans, reduce the stated rate of any
interest or fee payable hereunder or extend the scheduled date of any payment
thereof, or increase the amount of any Lender's Commitment, in each case,
without the written consent of each Lender directly affected thereby; (ii)
eliminate or reduce the voting rights of any Lender under this Section 11.1
without the written consent of such Lender; (iii) reduce any percentage
specified in the definition of

                                       58
<PAGE>

Required Lenders, consent to the assignment or transfer by the Borrowers of any
of its rights and obligations under this Agreement and the other Loan Documents,
release all or substantially all of the Collateral or release all or
substantially all of the Subsidiary Guarantors from their obligations under the
Guarantee and Collateral Agreement, in each case without the written consent of
all Lenders; (iv) amend, modify or waive any provision of Section 6.2 without
the written consent of each Lender adversely affected thereby; (v) reduce the
amount of Net Cash Proceeds required to be applied to prepay the Obligations
under this Agreement without the written consent of each Lender adversely
affected thereby; or (vi) amend, modify or waive any provision of Section 10
without the written consent of the Administrative Agent. Any such waiver and any
such amendment, supplement or modification shall apply equally to each of the
Lenders and shall be binding upon the Loan Parties, the Lenders, the
Administrative Agent and all future holders of the Obligations. In the case of
any waiver, the Loan Parties, the Lenders and the Administrative Agent shall be
restored to their former position and rights hereunder and under the other Loan
Documents, and any Default or Event of Default waived shall be deemed to be
cured and not continuing; but no such waiver shall extend to any subsequent or
other Default or Event of Default, or impair any right consequent thereon.

            11.2 Notices. All notices, requests and demands to or upon the
respective parties hereto to be effective shall be in writing (including by
telecopy), and, unless otherwise expressly provided herein, shall be deemed to
have been duly given or made when delivered, or three (3) Business Days after
being deposited in the mail, postage prepaid, or, in the case of telecopy
notice, when received, addressed as follows in the case of the Borrower
Representative and the Administrative Agent, and as set forth in an
administrative questionnaire delivered to the Administrative Agent in the case
of the Lenders, or to such other address as may be hereafter notified by the
respective parties hereto:

   Borrower Representative:          Zila, Inc.
                                     5227 North 7th Street
                                     Phoenix, AZ 85014
                                     Attention:  Andrew A. Stevens
                                     Telecopy:   602-230-8418
                                     Telephone:  602-280-1211

   with a copy to:                   Snell & Wilmer L.L.P.
                                     One Arizona Center
                                     Phoenix, AZ 85004
                                     Attention:  Mike Donahey, Esq.
                                     Telecopy:   602-382-6000
                                     Telephone:  602-382-6070

   The Administrative Agent:         Black Diamond Commercial Finance, L.L.C.
                                     Two Stamford Plaza
                                     281 Tresser Blvd., 7th Floor
                                     Stamford, CT 06901-3242
                                     Attention: John N. McDevitt
                                     Telecopy:  203-674-7808
                                     Telephone: 203-425-1480

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<PAGE>

   with a copy to:                   Paul, Hastings, Janofsky & Walker LLP
                                     75 East 55th Street
                                     New York, NY 10020
                                     Attention: Leslie A. Plaskon, Esq.
                                     Telecopy:  212-230-5137
                                     Telephone: 212-318-6421

   and

                                     The Bank of New York
                                     600 E. Las Colinas Blvd., Suite 1300
                                     Irving, TX  75039
                                     Attention: Aretha A. Velasquez
                                     Telecopy:  972-401-8557
                                     Telephone: 972-401-8628

; provided that any notice, request or demand to or upon the Administrative
Agent or the Lenders shall not be effective until received.

            Notices and other communications to the Lenders hereunder may be
delivered or furnished by electronic communications pursuant to procedures
approved by the Administrative Agent; provided that the foregoing shall not
apply to notices pursuant to Section 2 unless otherwise agreed to by the
Administrative Agent and the applicable Lender. The Administrative Agent or the
Borrower Representative may, in its discretion, agree to accept notices and
other communications to it hereunder by electronic communications pursuant to
procedures approved by it; provided that approval of such procedures may be
limited to particular notices or communications.

            11.3 No Waiver; Cumulative Remedies. No failure to exercise and no
delay in exercising, on the part of the Administrative Agent or any Lender, any
right, remedy, power or privilege hereunder or under the other Loan Documents
shall operate as a waiver thereof; nor shall any single or partial exercise of
any right, remedy, power or privilege hereunder preclude any other or further
exercise thereof or the exercise of any other right, remedy, power or privilege.
The rights, remedies, powers and privileges herein provided are cumulative and
not exclusive of any rights, remedies, powers and privileges provided by law.

            11.4 Survival of Representations and Warranties. All representations
and warranties made hereunder, in the other Loan Documents and in any document,
certificate or statement delivered pursuant hereto or in connection herewith
shall survive the execution and delivery of this Agreement and the making of the
Loans and other extensions of credit hereunder.

            11.5 Payment of Expenses and Taxes. The Borrowers agree (a) to pay
or reimburse the Administrative Agent for all of its out-of-pocket costs and
expenses incurred in connection with the development, preparation and execution
of, and any amendment, supplement or modification to, this Agreement and the
other Loan Documents and any other documents prepared in connection herewith or
therewith, and the consummation and administration of the transactions
contemplated hereby and thereby, including the reasonable fees and disbursements
of counsel to the Administrative Agent and filing and recording fees and
expenses, with

                                       60
<PAGE>

statements with respect to the foregoing to be submitted to the Borrower
Representative prior to the Closing Date (in the case of amounts to be paid on
the Closing Date) and from time to time thereafter on a quarterly basis or such
other periodic basis as the Administrative Agent shall deem appropriate, (b) to
pay or reimburse each Lender and the Administrative Agent for all its costs and
expenses incurred in connection with the enforcement or preservation of any
rights under this Agreement, the other Loan Documents and any such other
documents, including the reasonable fees and disbursements of counsel (including
the allocated fees and expenses of in-house counsel) to each Lender and of
counsel to the Administrative Agent, (c) to pay, indemnify, and hold each Lender
and the Administrative Agent harmless from, any and all recording and filing
fees and any and all liabilities with respect to, or resulting from, any delay
in paying, stamp, excise and other taxes, if any, that may be payable or
determined to be payable in connection with the execution and delivery of, or
consummation or administration of, any of the transactions contemplated by, or
any amendment, supplement or modification of, or any waiver or consent under or
in respect of, this Agreement, the other Loan Documents and any such other
documents, and (d) to pay, indemnify, and hold each Lender and the
Administrative Agent and their respective officers, directors, employees,
affiliates, agents and controlling persons (each, an "Indemnitee") harmless from
and against any and all other liabilities, obligations, losses, damages,
penalties, actions, judgments, suits, costs, expenses or disbursements of any
kind or nature whatsoever with respect to the execution, delivery, enforcement,
performance and administration of this Agreement, the other Loan Documents
(regardless of whether any Loan Party is or is not a party to any such actions
or suits) and any such other documents, including any of the foregoing relating
to the use of proceeds of the Loans or the violation of, noncompliance with or
liability under, any Environmental Law applicable to the operations of any Group
Member or any of the Properties and the reasonable fees and expenses of legal
counsel in connection with claims, actions or proceedings by any Indemnitee
against any Loan Party under any Loan Document (all the foregoing in this clause
(d), collectively, the "Indemnified Liabilities"), provided, that the Borrowers
shall have no obligation hereunder to any Indemnitee with respect to Indemnified
Liabilities to the extent such Indemnified Liabilities are found by a final and
nonappealable decision of a court of competent jurisdiction to have resulted
from the gross negligence or willful misconduct of such Indemnitee. Without
limiting the foregoing, and to the extent permitted by applicable law, the
Borrowers agree not to assert and to cause their respective Subsidiaries not to
assert, and hereby waive and agree to cause their respective Subsidiaries to
waive, all rights for contribution or any other rights of recovery with respect
to all claims, demands, penalties, fines, liabilities, settlements, damages,
costs and expenses of whatever kind or nature, under or related to Environmental
Laws, that any of them might have by statute or otherwise against any
Indemnitee. All amounts due under this Section 11.5 shall be payable not later
than 10 days after written demand therefor. Statements payable by the Borrowers
pursuant to this Section 11.5 shall be submitted to Andrew A. Stevens at the
address of the Borrower Representative set forth in Section 11.2, or to such
other Person or address as may be hereafter designated by the Borrower
Representative in a written notice to the Administrative Agent. The agreements
in this Section 11.5 shall survive repayment of the Loans and all other amounts
payable hereunder.

            11.6 Successors and Assigns; Participations and Assignments. (a) The
provisions of this Agreement shall be binding upon and inure to the benefit of
the parties hereto and their respective successors and assigns permitted hereby,
except that (i) no Borrower may assign or otherwise transfer any of its rights
or obligations hereunder without the prior written

                                       61
<PAGE>

consent of each Lender (and any attempted assignment or transfer by any Borrower
without such consent shall be null and void) and (ii) no Lender may assign or
otherwise transfer its rights or obligations hereunder except in accordance with
this Section.

            (b) (i) Subject to the conditions set forth in paragraph (b)(ii)
below, any Lender may assign to one or more assignees (each, an "Assignee") all
or a portion of its rights and obligations under this Agreement (including all
or a portion of its Commitments and the Loans at the time owing to it) with the
prior written consent (such consent not to be unreasonably withheld) of:

                  (A) the Borrowers; provided that no consent of the Borrowers
            shall be required for an (x) assignment to a Lender, an affiliate of
            a Lender, an Approved Fund (as defined below) or, if an Event of
            Default has occurred and is continuing, any other Person and (y) any
            assignment by the Administrative Agent (or its affiliates) to any
            affiliate of the Administrative Agent; and

                  (B) the Administrative Agent; provided that no consent of the
            Administrative Agent shall be required for (x) an assignment to an
            Assignee that is a Lender immediately prior to giving effect to such
            assignment or (y) any assignment by the Administrative Agent (or its
            affiliates); and

                  (ii) Assignments shall be subject to the following additional
conditions:

                  (A) except in the case of an assignment to a Lender, an
            affiliate of a Lender or an Approved Fund or an assignment of the
            entire remaining amount of the assigning Lender's Commitments or
            Loans, the amount of the Commitments or Loans of the assigning
            Lender subject to each such assignment (determined as of the date
            the Assignment and Assumption with respect to such assignment is
            delivered to the Administrative Agent) shall not be less than
            $1,000,000 unless each of the Borrowers and the Administrative Agent
            otherwise consent; provided that (1) no such consent of -------- the
            Borrowers shall be required if an Event of Default has occurred and
            is continuing and (2) such amounts shall be aggregated in respect of
            each Lender and its affiliates or Approved Funds, if any;

                  (B) the parties to each assignment shall execute and deliver
            to the Administrative Agent an Assignment and Assumption, together
            with a processing and recordation fee of $3,500 unless otherwise
            agreed to by the Administrative Agent;

                  (C) the Assignee, if it shall not be a Lender, shall deliver
            to the Administrative Agent an administrative questionnaire; and

                  (D) in the case of an assignment to a related CLO (as defined
            below), the assigning Lender shall retain the sole right to approve
            any amendment, modification or waiver of any provision of this
            Agreement and the other Loan Documents; provided that the Assignment
            and Assumption between such Lender and such CLO may provide that
            such Lender will not, without the consent of such

                                       62
<PAGE>

            CLO, agree to any amendment, modification or waiver that (1)
            requires the consent of each Lender directly affected thereby
            pursuant to the proviso to the second sentence of Section 11.1 and
            (2) directly affects such CLO.

            For the purposes of this Section 11.6, the terms "Approved Fund" and
"CLO" have the following meanings:

            "Approved Fund" means (a) a CLO and (b) with respect to any Lender
that is a fund which invests in bank loans and similar extensions of credit, any
other fund that invests in bank loans and similar extensions of credit and is
managed by the same investment advisor as such Lender or by an affiliate of such
investment advisor.

            "CLO" means any entity (whether a corporation, partnership, trust or
otherwise) that is engaged in making, purchasing, holding or otherwise investing
in bank loans and similar extensions of credit in the ordinary course of its
business and is administered or managed by a Lender or an affiliate of such
Lender.

                  (iii) Subject to acceptance and recording thereof pursuant to
paragraph (b)(iv) below, from and after the effective date specified in each
Assignment and Assumption the Assignee thereunder shall be a party hereto and,
to the extent of the interest assigned by such Assignment and Assumption, have
the rights and obligations of a Lender under this Agreement, and the assigning
Lender thereunder shall, to the extent of the interest assigned by such
Assignment and Assumption, be released from its obligations under this Agreement
(and, in the case of an Assignment and Assumption covering all of the assigning
Lender's rights and obligations under this Agreement, such Lender shall cease to
be a party hereto but shall continue to be entitled to the benefits of Sections
4.6, 4.7 and 10.5). Any assignment or transfer by a Lender of rights or
obligations under this Agreement that does not comply with this Section 11.6
shall be treated for purposes of this Agreement as a sale by such Lender of a
participation in such rights and obligations in accordance with paragraph (c) of
this Section.

                  (iv) The Administrative Agent, acting for this purpose as an
agent of the Borrowers, shall maintain at one of its offices a copy of each
Assignment and Assumption delivered to it and a register for the recordation of
the names and addresses of the Lenders, and the Commitments of, and principal
amount of the Loans owing to, each Lender pursuant to the terms hereof from time
to time (the "Register"). The entries in the Register shall be conclusive, and
the Borrowers, the Administrative Agent and the Lenders may treat each Person
whose name is recorded in the Register pursuant to the terms hereof as a Lender
hereunder for all purposes of this Agreement, notwithstanding notice to the
contrary.

                  (v) Upon its receipt of a duly completed Assignment and
Assumption executed by an assigning Lender and an Assignee, the Assignee's
completed administrative questionnaire (unless the Assignee shall already be a
Lender hereunder), the processing and recordation fee referred to in paragraph
(b) of this Section and any written consent to such assignment required by
paragraph (b) of this Section, the Administrative Agent shall accept such
Assignment and Assumption and record the information contained therein in the
Register. No assignment shall be effective for purposes of this Agreement unless
it has been recorded in the Register as provided in this paragraph.

                                       63
<PAGE>

            (c) (i) Any Lender may, without the consent of the Borrowers or the
Administrative Agent, sell participations to one or more banks or other entities
(a "Participant") in all or a portion of such Lender's rights and obligations
under this Agreement (including all or a portion of its Commitments and the
Loans owing to it); provided that (A) such Lender's obligations under this
Agreement shall remain unchanged, (B) such Lender shall remain solely
responsible to the other parties hereto for the performance of such obligations
and (C) the Borrowers, the Administrative Agent and the other Lenders shall
continue to deal solely and directly with such Lender in connection with such
Lender's rights and obligations under this Agreement. Any agreement pursuant to
which a Lender sells such a participation shall provide that such Lender shall
retain the sole right to enforce this Agreement and to approve any amendment,
modification or waiver of any provision of this Agreement; provided that such
agreement may provide that such Lender will not, without the consent of the
Participant, agree to any amendment, modification or waiver that (1) requires
the consent of each Lender directly affected thereby pursuant to the proviso to
the second sentence of Section 11.1 and (2) directly affects such Participant.
Subject to paragraph (c)(ii) of this Section, the Borrowers agree that each
Participant shall be entitled to the benefits of Sections 4.6 and 4.7 to the
same extent as if it were a Lender and had acquired its interest by assignment
pursuant to paragraph (b) of this Section. To the extent permitted by law, each
Participant also shall be entitled to the benefits of Section 11.7(b) as though
it were a Lender, provided such Participant shall be subject to Section 11.7(a)
as though it were a Lender.

                  (ii) A Participant shall not be entitled to receive any
greater payment under Section 4.7 or 4.8 than the applicable Lender would have
been entitled to receive with respect to the participation sold to such
Participant, unless the sale of the participation to such Participant is made
with the Borrowers' prior written consent. Any Participant that is a Non-U.S.
Lender shall not be entitled to the benefits of Section 4.8 unless such
Participant complies with Section 4.8(d).

            (d) Any Lender may at any time pledge or assign a security interest
in all or any portion of its rights under this Agreement to secure obligations
of such Lender, including any pledge or assignment to secure obligations to a
Federal Reserve Bank, and this Section shall not apply to any such pledge or
assignment of a security interest; provided that no such pledge or assignment of
a security interest shall release a Lender from any of its obligations hereunder
or substitute any such pledgee or Assignee for such Lender as a party hereto.

            (e) The Borrowers, upon receipt of written notice from the relevant
Lender, agree to issue Notes to any Lender requiring Notes to facilitate
transactions of the type described in paragraph (d) above.

            (f) Notwithstanding the foregoing, any Conduit Lender may assign any
or all of the Loans it may have funded hereunder to its designating Lender
without the consent of the Borrowers or the Administrative Agent and without
regard to the limitations set forth in Section 11.6(b). Each Borrower, Lender
and the Administrative Agent hereby confirms that it will not institute against
a Conduit Lender or join any other Person in instituting against a Conduit
Lender any bankruptcy, reorganization, arrangement, insolvency or liquidation
proceeding under any state bankruptcy or similar law, for one year and one day
after the payment in full of the latest maturing commercial paper note issued by
such Conduit Lender; provided,

                                       64
<PAGE>

however, that each Lender designating any Conduit Lender hereby agrees to
indemnify, save and hold harmless each other party hereto for any loss, cost,
damage or expense arising out of its inability to institute such a proceeding
against such Conduit Lender during such period of forbearance.

            11.7 Adjustments; Set-off. (a) Except to the extent that this
Agreement expressly provides for payments to be allocated to a particular Lender
or to the Lenders under a particular Facility, if any Lender (a "Benefited
Lender") shall receive any payment of all or part of the Obligations owing to
it, or receive any collateral in respect thereof (whether voluntarily or
involuntarily, by set-off, pursuant to events or proceedings of the nature
referred to in Section 9(f), or otherwise), in a greater proportion than any
such payment to or collateral received by any other Lender, if any, in respect
of the Obligations owing to such other Lender, such Benefited Lender shall
purchase for cash from the other Lenders a participating interest in such
portion of the Obligations owing to each such other Lender, or shall provide
such other Lenders with the benefits of any such collateral, as shall be
necessary to cause such Benefited Lender to share the excess payment or benefits
of such collateral ratably with each of the Lenders; provided, however, that if
all or any portion of such excess payment or benefits is thereafter recovered
from such Benefited Lender, such purchase shall be rescinded, and the purchase
price and benefits returned, to the extent of such recovery, but without
interest.

            (b) In addition to any rights and remedies of the Lenders provided
by law, each Lender shall have the right, without prior notice to the Borrowers,
any such notice being expressly waived by the Borrowers to the extent permitted
by applicable law, upon any amount becoming due and payable by the Borrowers
hereunder (whether at the stated maturity, by acceleration or otherwise), to set
off and appropriate and apply against such amount any and all deposits (general
or special, time or demand, provisional or final), in any currency, and any
other credits, indebtedness or claims, in any currency, in each case whether
direct or indirect, absolute or contingent, matured or unmatured, at any time
held or owing by such Lender or any branch or agency thereof to or for the
credit or the account of the Borrowers, as the case may be. Each Lender agrees
promptly to notify the Borrowers and the Administrative Agent after any such
setoff and application made by such Lender; provided that the failure to give
such notice shall not affect the validity of such setoff and application.

            11.8 Counterparts. This Agreement may be executed by one or more of
the parties to this Agreement on any number of separate counterparts, and all of
said counterparts taken together shall be deemed to constitute one and the same
instrument. Delivery of an executed signature page of this Agreement by
facsimile transmission shall be effective as delivery of a manually executed
counterpart hereof. A set of the copies of this Agreement signed by all the
parties shall be lodged with the Borrower Representative and the Administrative
Agent.

            11.9 Severability. Any provision of this Agreement that is
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

                                       65
<PAGE>

            11.10 Integration. This Agreement and the other Loan Documents
represent the entire agreement of the Borrowers, the Administrative Agent and
the Lenders with respect to the subject matter hereof and thereof, and there are
no promises, undertakings, representations or warranties by the Administrative
Agent or any Lender relative to subject matter hereof not expressly set forth or
referred to herein or in the other Loan Documents.

            11.11 GOVERNING LAW. THIS AGREEMENT AND THE RIGHTS AND OBLIGATIONS
OF THE PARTIES UNDER THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED AND
INTERPRETED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.

            11.12 Submission To Jurisdiction; Waivers. Each Borrower hereby
irrevocably and unconditionally:

            (a) submits for itself and its property in any legal action or
      proceeding relating to this Agreement and the other Loan Documents to
      which it is a party, or for recognition and enforcement of any judgment in
      respect thereof, to the non-exclusive general jurisdiction of the courts
      of the State of New York, the courts of the United States for the Southern
      District of New York, and appellate courts from any thereof;

            (b) consents that any such action or proceeding may be brought in
      such courts and waives any objection that it may now or hereafter have to
      the venue of any such action or proceeding in any such court or that such
      action or proceeding was brought in an inconvenient court and agrees not
      to plead or claim the same;

            (c) agrees that service of process in any such action or proceeding
      may be effected by mailing a copy thereof by registered or certified mail
      (or any substantially similar form of mail), postage prepaid, to the
      Borrower Representative at its address set forth in Section 11.2 or at
      such other address of which the Administrative Agent shall have been
      notified pursuant thereto;

            (d) agrees that nothing herein shall affect the right to effect
      service of process in any other manner permitted by law or shall limit the
      right to sue in any other jurisdiction; and

            (e) waives, to the maximum extent not prohibited by law, any right
      it may have to claim or recover in any legal action or proceeding referred
      to in this Section any special, exemplary and punitive damages.

            11.13 Acknowledgments. Each Borrower hereby acknowledges that:

            (a) it has been advised by counsel in the negotiation, execution and
      delivery of this Agreement and the other Loan Documents;

            (b) Neither the Administrative Agent nor any Lender has any
      fiduciary relationship with or duty to any Borrower arising out of or in
      connection with this Agreement or any of the other Loan Documents, and the
      relationship between the

                                       66
<PAGE>

      Administrative Agent and Lenders, on the one hand, and the Borrowers, on
      the other hand, in connection herewith or therewith is solely that of
      debtor and creditor; and

            (c) no joint venture is created hereby or by the other Loan
      Documents or otherwise exists by virtue of the transactions contemplated
      hereby among the Lenders or among the Borrowers and the Lenders.

            11.14 Releases of Guarantees and Liens. (a) Notwithstanding anything
to the contrary contained herein or in any other Loan Document, the
Administrative Agent is hereby irrevocably authorized by each Lender (without
requirement of notice to or consent of any Lender except as expressly required
by Section 11.1) to take any action requested by the Borrower Representative
having the effect of releasing any Collateral or guarantee obligations (i) to
the extent necessary to permit consummation of any transaction not prohibited by
any Loan Document or that has been consented to in accordance with Section 11.1
or (ii) under the circumstances described in paragraph (b) below.

            (b) At such time as the Loans and all other Obligations under the
Loan Documents shall have been paid in full, the Commitments have been
terminated, the Collateral shall be released from the Liens created by the
Security Documents, and the Security Documents and all obligations (other than
those expressly stated to survive such termination) of the Administrative Agent
and each Loan Party under the Security Documents shall terminate, all without
delivery of any instrument or performance of any act by any Person.

            11.15 Confidentiality. The Administrative Agent and each Lender
agree to keep confidential all non-public information provided to them by any
Loan Party pursuant to this Agreement that is designated by such Loan Party as
confidential; provided that nothing herein shall prevent the Administrative
Agent or any Lender from disclosing any such information (a) to any other Lender
or any Lender Affiliate, (b) subject to an agreement to comply with the
provisions of this Section, to any actual or prospective Transferee, (c) to its
employees, directors, agents, attorneys, accountants and other professional
advisors or those of any of its affiliates, (d) in response to any order of any
court or other Governmental Authority or as may otherwise be required pursuant
to any Requirement of Law, (e) if requested or required to do so in connection
with any litigation or similar proceeding, (f) that has been publicly disclosed,
(g) to the National Association of Insurance Commissioners or any similar
organization or any nationally recognized rating agency that requires access to
information about a Lender's investment portfolio in connection with ratings
issued with respect to such Lender, or (h) in connection with the exercise of
any remedy hereunder or under any other Loan Document.

            11.16 WAIVERS OF JURY TRIAL. EACH BORROWER, THE ADMINISTRATIVE AGENT
AND EACH LENDER HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVE TRIAL BY JURY IN
ANY LEGAL ACTION OR PROCEEDING RELATING TO THIS AGREEMENT OR ANY OTHER LOAN
DOCUMENT AND FOR ANY COUNTERCLAIM THEREIN.

                            [Signature Pages Follow]

                                       67
<PAGE>

            IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed and delivered by their proper and duly authorized officers as
of the day and year first above written.

                                 BORROWERS:

                                 ZILA, INC.

                                 By:  /s/ Andrew A. Stevens
                                      ------------------------------------------
                                      Name:  Andrew A. Stevens
                                      Title: Vice President & CFO

                                 ZILA TECHNICAL, INC.

                                 By:  /s/ Gary V. Klinefelter
                                      ------------------------------------------
                                      Name:  Gary V. Klinefelter
                                      Title: Vice President

                                 ZILA BIOTECHNOLOGY, INC.

                                 By:  /s/ Gary V. Klinefelter
                                      ------------------------------------------
                                      Name:  Gary V. Klinefelter
                                      Title: Vice President

                                 ZILA NUTRACEUTICALS, INC.

                                 By:  /s/ Andrew A. Stevens
                                      ------------------------------------------
                                      Name:  Andrew A. Stevens
                                      Title: Vice President & CFO

<PAGE>

                                 ZILA PHARMACEUTICALS, INC.

                                 By:  /s/ Andrew A. Stevens
                                      ------------------------------------------
                                      Name:  Andrew A. Stevens
                                      Title: Vice President & CFO

                                 ZILA SWAB TECHNOLOGIES, INC.

                                 By:  /s/ Gary V. Klinefelter
                                      ------------------------------------------
                                      Name:  Gary V. Klinefelter
                                      Title: Vice President

<PAGE>

                               LENDER:

                               BLACK DIAMOND COMMERCIAL
                                 FINANCE, L.L.C., as Administrative Agent and
                                 the Initial Term Lender

                               By:  /s/ Stuart Armstrong
                                    --------------------------------------------
                                    Name:  Stuart Armstrong
                                    Title: President and Chief Executive Officer

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