Document:

Exhibit 10.81b

    
      10.81b

      

      GUARANTY
        OF LEASE

      

      FOR
        V ALUE
        RECEIVED, and in consideration for, and as an inducement to Oxbridge Development
        at Crown Pointe, L.C., a Maryland limited liability company, to consent to
        an
        assignment by merger of the lease for space at 620 Professional Drive,
        Gaithersburg, Md. 20879 dated as of October 26, 2000, (the “Lease”), in which it
        is "Landlord" to GLA II Corp., a Delaware corporation (to be renamed TherImmune
        Research Corporation at the time of the merger) (“Tenant"), a wholly-owned
        subsidiary of the undersigned and successor in interest by merger to TherImmune
        Research Corporation, a Maryland corporation, the original tenant under the
        Lease, the undersigned, whether one or more, jointly and severally do hereby
        unconditionally guarantee to Landlord (i)l the punctual and full payment
        of all
        rents of every kind, additional rents and all other charges to be paid by
        Tenant
        under the Lease and (ii) the full and timely performance and observance of
        all
        the covenants, conditions, and agreements to be performed and observed by
        Tenant
        under the Lease. The undersigned shall indemnify, defend and hold harmless
        Landlord and its affiliates from any loss, damages or costs (including without
        limitation, the reasonable fees of Landlord's attorneys and court costs,
        but
        excluding any indirect, consequential, exemplary or punitive damages) arising
        out of any failure to pay the aforesaid rents and other charges or the failure
        to perform any of the aforesaid covenants, conditions and agreements under
        the
        Lease, except to the extent arising out of the negligence or intentional
        misconduct of Landlord or its agents or property manager. The undersigned
        further expressly agree that the validity of this Lease and the obligations
        of
        the undersigned hereunder shall in no way be terminated, affected or impaired
        by
        reason of any forbearances, settlements or compromises between Landlord and
        Tenant or the relief of Tenant from any of Tenant's obligations under the
        Lease
        by operation of law, such as the rejection or assignment of the Lease in
        connection with proceedings under any present or future provision of the
        federal
        Bankruptcy Act, or any similar law or statute of the United States or any
        state
        thereof.

      

      The
        undersigned further covenant and agree that this Guaranty of Lease shall
        be and
        remain in full force and effect as to any renewal, modification or extension
        of
        the Lease, whether or not known to or approved by the undersigned, but this
        Guaranty shall not remain in effect if the Tenant's interest in the Lease
        is
        assigned, with Landlord's written consent, to a third party which is not
        owned
        and controlled by the undersigned. In the event of any termination of the
        Lease
        by Landlord, the undersigned's liability hereunder shall not be terminated,
        but
        the undersigned shall be and remain fully liable for the performance of the
        Tenant's obligations, if any, under the Lease. If the undersigned shall,
        directly or indirectly, advance .any sums to Tenant, such sums and indebtedness
        shall be subordinate in all respects to the amounts then and thereafter due
        and
        owing by Tenant under the Lease.

      

      Wherever
        reference is made to the liability of Tenant in the Lease, such reference
        shall
        he deemed likewise to refer to the undersigned, jointly and severally, with
        Tenant. The liability of the undersigned for the obligations of Tenant under
        the
        Lease shall be primary, absolute and unconditional. In any right of action
        which
        shall accrue to Landlord under the Lease, Landlord may, at Landlord's option,
        proceed against any one or more of the undersigned and/or Tenant, jointly
        or
        severally, and .may proceed against any one or more of the undersigned without
        having demanded performance of, commenced any action against or having obtained
        any judgment against Tenant The undersigned hereby expressly waive: (i) notice
        of acceptance of this Guaranty of Lease and of presentment, demand and protest;
        and (ii) notice to the undersigned of any default hereunder or under the
        Lease;
        provided, however that this waiver shall not constitute a waiver of any
        obligation of the Landlord pursuant to the Lease to give Tenant notice and
        an
        opportunity to cure defaults under the Lease. This Guaranty of Lease is a
        guaranty of payment and not a guaranty of collection. The undersigned agree
        that
        in the event this Guaranty of Lease shall be enforced by suit or otherwise,
        and
        the Landlord shall prevail in any such action, the undersigned will reimburse
        the Landlord, upon demand, for an expenses incurred in connection therewith,
        including, without limitation, reasonable attorneys' fees.

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

       

      The
        undersigned hereby waive, to the maximum extent permitted bylaw, any statute.
        of
        limitations affecting the enforcement of this Guaranty of Lease.

      

      THE
        UNDERSIGNED HEREBY KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVE THE RIGHT
        TO A
        TRIAL BY JURY IN RESPECT OF ANY LITIGATION BASED HEREON, ARISING OUT OF,
        UNDER
        OR IN CONNECTION WITH THIS GUARANTY OF LEASE OR ANY DOCUMENTS CONTEMPLATED
        TO BE
        EXECUTED IN CONNECTION HEREWITH OR ANY COURSE OF CONDUCT, COURSE OF DEALINGS,
        STATEMENTS (WHETHER ORAL OR WRITTEN) OR ACTIONS OF THE UNDERSIGNED OR LANDLORD
        ARISING OUT OR RELATED IN ANY MANNER WITH THIS GUARANTY OF LEASE (INCLUDING
        WITHOUT LIMITATION, ANY ACTION TO RESCIND OR CANCEL THIS GUARANTY OF LEASE
        OR
        ANY CLAIMS OR DEFENSES ASSERTING THAT THIS GUARANTY OF LEASE WAS FRAUDULENTLY
        INDUCED OR IS OTHERWISE VOID OR VOIDABLE). THIS WAIVER IS A MATERIAL INDUCEMENT
        FOR LANDLORD TO CONSENT TO THE ASSIGNMENT OF THE LEASE AS DESCRIBED
        ABOVE.

      

      The
        undersigned hereby assign to Landlord any rights the undersigned may have
        to
        file a claim and proof of claim in any bankruptcy or similar proceeding of
        Tenant and any awards of payments thereon to which the undersigned would
        otherwise be entitled.

      

      It
        is
        further agreed that all of the terms and provisions hereof shall inure to
        the
        benefit of and may be enforced by the respective heirs, executors, successors
        and assigns of Landlord and the holder of any mortgage to which the Lease
        may be
        subject and subordinate from time to time, and shall be binding upon the
        respective heirs, executors, successors and assigns of the undersigned. Landlord
        may, without notice, assign this Guaranty of Lease (in connection with the
        assignment of the Lease), and no such assignment shall increase or diminish
        the
        undersigned's liability under this Guaranty of Lease.

      

      In
        the
        event more than one person or entity executes this Guaranty of Lease, the
        liability of such signatories hereunder shall be joint and several. In the
        event
        only one person or entity executes this Guaranty of Lease, an provisions
        hereof
        which refer to more than one guarantor shall be automatically modified to
        refer
        to only one guarantor, and otherwise this Guaranty of Lease shall remain
        unmodified and in full force and effect

      

      It
        is
        understood that other agreements similar to this Guaranty of Lease may, at
        Landlord's sole option and discretion, be executed by other persons with
        respect
        to the Lease. This Guaranty of Lease shall be cumulative of any such agreements
        and the liabilities and obligations of the undersigned hereunder shall in
        no
        event be affected or diminished by reason of such other agreements. Moreover,
        in
        the event Landlord obtains the signature of more than one guarantor on this
        Guaranty of Lease or obtains additional guarantee agreements, or both, the
        undersigned agree that Landlord, in Landlord's sole discretion, may (i) compound
        or settle with anyone or more of the guarantors for such consideration as
        Landlord may deem proper, and (ii) release one or more of the guarantors
        from
        liability. The undersigned further agree that no such action shall impair
        the
        rights of Landlord to enforce the Lease against any remaining guarantor or
        guarantors, including the undersigned.

      

      The
        undersigned agree to execute and deliver to Landlord, from time to time,
        upon
        ten (10) business days notice from Landlord, a certificate addressed to
        Landlord, any mortgagee or prospective mortgagee, or any prospective purchase,
        certifying (i) that this Guaranty of Lease is unmodified and in full force
        and
        effect and (ii) to such other matters as Landlord may reasonably
        request.

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

       

      If
        any
        provision of this Guaranty of Lease or the application thereof to any person
        or
        circumstance shall, for any reason and to any extent, be invalid or
        unenforceable, the remainder of this Guaranty of Lease and the application
        of
        that provision to other persons or circumstances shall not be affected but
        rather shall be enforced to the fullest extent permitted by law.

      

      If
        the
        undersigned is a corporation (including any form of professional association),
        then each individual executing or attesting this Guaranty of Lease on behalf
        of
        such corporation covenants, warrants and represents that he or she is duly
        authorized to execute or attest and deliver this Guaranty of Lease on behalf
        of
        such corporation. If the undersigned is a partnership (general or limited)
        or
        limited liability company, then each individual executing this Guaranty of
        Lease
        on behalf of the partnership or company hereby covenants, warrants and
        represents that he or she is duly authorized to execute and deliver this
        Guaranty of Lease on behalf of the partnership or company in accordance with
        the
        partnership agreement or membership agreement, as the case may be, or an
        amendment thereto, now in effect.

      

      This
        Guaranty of Lease shall be governed by the Jaws of the State of Maryland,
        exc1udingchoice of laws principles.

      

      EXECUTED
        UNDER SEAL as of the 1st day of April 2003

    

     

    
      
        	 	GUARANTOR:
	 	 
	 	GENE
                LOGIC INC., a Delaware corporation

      

       

      
        
          	
                   

                	
                  By:

                	
                  /s/
                    Philip L. Rohrer, Jr.

                	
                
	 
	
                   

                	
                  Name:

                	
                  Philip
                    L Rohrer, Jr.

                	
                
	 
	
                   

                	
                  Title:

                	
                  Chief
                    Financial OfficerExhibit 10.88a

    10.88a

    

    Second
      Amendment to Executive Employment Agreement

    

    This
      Second Amendment (the “Amendment”) is made as of the 23rd day of February, 2007
      by and between Gene
      Logic
      Inc., a Delaware corporation (the “Company”), and V. W. Brinkerhoff, III (the
“Executive”). 

    

    Recitals:

    

    The
      parties to this amendment have previously entered into an Executive Employment
      Agreement dated March 6, 2005 (the “Agreement”) that was amended by a First
      Amendment dated as of December 18, 2006 (the “First Amendment”). Terms not
      otherwise defined herein shall have the meanings as defined in the
      Agreement.

    

    Upon
      sale
      of the Company’s Preclinical Division, Executive became entitled to various
      payments under the Company’s Executive Severance Plan in the event of
      termination of his employment without cause by the Company or upon certain
      changes in his duties and the parties agreed that his employment would end
      no
      later than March 31, 2007. The parties now wish to further amend the Agreement
      to provide for a continuation of Executive’s full-time employment and a change
      of duties and certain benefits and payments Executive will receive. The parties
      also wish to agree to certain current payments to be made and to provide that
      such current payments are in lieu of any payment of base salary and/or bonus
      under the Company’s Executive Severance Plan or upon the eventual termination of
      his employment. 

    

    Now,
      Therefore, the parties to this amendment hereby agree as follows:

    

    
      	 	
              1.

            	
              Superseding
                of First Amendment.
                The parties agree that this amendment supersedes and replaces the
                First
                Amendment and that, as a result, when this amendment becomes effective,
                the First Amendment shall be null and void and of no effect.
                

            

    

    
      	 	
              2.

            	
              Change
                in Duties. Section 1.1(a) of the Agreement is hereby amended by adding
                the
                following sentence at the end of such
                subsection:

            

    

    “From
      and
      after February 23, 2007, Company shall employ Executive as Senior Vice President
      - Administration, reporting to the Company’s Chief Executive Officer (“CEO”);
      the Executive’s duties shall be such executive and management duties and other
      responsibilities as may be assigned to him by the CEO. 

    

    2.
      Changes
      in benefits.
      

    

    (a)
      Section 3.2 is hereby amended by adding the following at the end of such
      subsection:

    “The
      cash
      incentive compensation (bonus) earned by Executive for 2006 will be $100,000.
      

    

    In
      addition, in consideration for agreeing to remain employed with the Company
      and
      foregoing certain payments otherwise due to Executive upon termination under
      the
      Company's Executive Severance Plan, or upon termination of his employment (but
      not foregoing the payments due upon severance pursuant to this amendment),
      Executive will be paid an amount equal to twelve months salary at the 2006
      rate,
      which amount shall be paid on or before April 24, 2007. Executive's salary
      for
      2007 shall be $250,000 and Executive will be eligible to participate in the
      Company’s 2007 incentive compensation plan with a target bonus, based on
      achieving 100% of the targets and levels of performance established by the
      Compensation Committee for 2007, of 40% of Executive’s base salary.

     

    
      	
              (b)

            	
              Section
                3.9 is hereby amended by deleting the same and substituting in lieu
                thereof the following:

            

    

    

    “In
      consideration of the payments described in Section 3.2, Executive: agrees that
      he is no longer entitled to payments or other rights and benefits under the
      Company’s Executive Severance Plan and waives all his rights
      thereunder.“

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     

    4.
      Benefits
      upon Termination without Cause.
      Subsection 4.7(a)(i) is hereby amended by deleting the same and substituting
      in
      lieu thereof the following:

    

    (a)
      (i)If
      Executive’s employment is terminated by the Company without Cause, the Company
      shall provide to the Executive the following compensation and benefits, upon
      the
      following terms:

    
      	 	
              §

            	
              Reimbursement
                of the insurance premium for post-employment health care coverage
                for
                which Executive is eligible under COBRA because of his prior employment
                by
                Company for a period equal to the lesser of (a) 12 months or (b)
                until
                Executive becomes eligible for coverage under a new employer’s plan. Such
                reimbursement will also include coverage for any dependents of Executive
                who are eligible for coverage under COBRA for the same period as
                Executive. Such reimbursement will be provided within a reasonable
                time
                following receipt by GLGC of confirmation of payment of the cost
                of such
                health insurance by Executive for the number of weeks covered. Executive
                may request periodic reimbursement, but not more often than monthly.
                Company may also elect to pay the premium directly to the party
                responsible for collecting such payments rather than providing
                reimbursement to Executive. Executive shall be obligated to notify
                the
                Company pr0omplty after Executive becomes eligible for coverage under
                a
                new employer’s plan.

            

    

    
      	 	
              §

            	
              If
                Executive’s employment
                is terminated by the Company without Cause prior to December 31,
                2007,
                Executive shall receive a percentage of the cash incentive compensation
                based on achievement of targets as described in Section 3.2 of the
                Agreement as revised by the Second Amendment that he would have received
                if he had continued to be employed by the Company through December
                31,
                2007 that is determined by dividing the number of days he was employed
                by
                the Company in 2007 by 365. Such payment shall be made in 2008 when
                other
                employees receive their payments after the amounts payable under
                the 2007
                incentive compensation plan have been determined
                

            

    

    
      	 	
              §

            	
              Notwithstanding
                the above, the reimbursement or payment of insurance premiums described
                above and, if applicable, the payment of a percentage of incentive
                compensation described above shall be paid or provided to Executive
                no
                earlier than the earliest date upon which such amounts can be paid
                without
                subjecting the Executive to the additional tax imposed by Code Section
                409A(a)(1), if applicable. The parties agree that this Agreement
                shall be
                amended to the extent necessary such that, under final regulations
                to be
                issued under Code Section 409A, none of the payments to be provided
                hereunder are subject to the additional tax imposed by Code Section
                409A(a)(1). 

            

    

    
      	 	
              §

            	
              The
                reimbursement or payment of such insurance premiums payment and,
                if
                applicable, the payment of a percentage of incentive compensation
                described above, is expressly conditioned on the receipt by Company
                of a
                release signed by Executive of claims arising from or connected with
                Executive’s employment by the Company, in such form as may be specified by
                the Company and the expiration of any revocation period specified
                in the
                release or by applicable law, without any revocation being made.
                The
                payments described in this subsection 4.7(a)(1) will not be paid
                or
                provided until the Company has received such release and the applicable
                period for revocation of such a signed release has expired without
                any
                revocation having been made. 

            

    

    

    5.
      Miscellaneous:

    
      	 	
              a.

            	
              The
                Agreement remains in full force and effect and unmodified except
                as
                specifically provided herein. Terms not otherwise defined herein
                shall
                have the meaning set forth in the Agreement.

            

    

    
      	 	
              b.

            	
              This
                amendment shall not be effective until this amendment has been approved
                by
                the Company’s Board of Directors or its Compensation Committee.
                

            

    

    

    To
      evidence their agreement to the terms of this Second Amendment, Executive has
      signed and Company has caused its duly authorized representative to sign this
      Second Amendment as of February 23, 2007

    

    
      	
              Gene
                Logic Inc.

               

              By:
                /s/
                Charles L. Dimmler, III

              Charles
                L. Dimmler, III

              CEO
                & President

            	
              Executive

               

              /s/
                V. W. Brinkerhoff, III

              V.
                W. Brinkerhoff, III

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