Document:

EX-10.6

 Exhibit 10.6 

LEASE AGREEMENT 
 THIS
LEASE AGREEMENT (this “Lease”) is made this 29 day of September, 2017, between ARE-SD REGION NO. 30, LLC, a Delaware limited liability company (“Landlord”), and XERIS PHARMACEUTICALS,
INC., a Delaware corporation (“Tenant”). 
  

			
	Building:	  	3985 Sorrento Valley Boulevard, San Diego, California
		
	Premises:	  	That portion of the Project containing approximately 17,105 rentable square feet (“rsf”), as determined by Landlord, as shown on Exhibit A.
		
	Project:	  	The real property on which the Building in which the Premises are located, together with all improvements thereon and appurtenances thereto as described on Exhibit B.
		
	Base Rent:	  	$3.40 per rsf of the Premises per month, subject to adjustment pursuant to Section 4 hereof.

  

			
	Rentable Area of Premises:	  	17,105 rsf
		
	Rentable Area of Project:	  	56,035 rsf

  

			
	Tenant’s Share of Operating Expenses:	 	30.52% (subject to adjustment pursuant to Section 5 hereof)

  

			
	Security Deposit:     $58,157.00	  	  Target Commencement Date:     June 1, 2018
		
	Rent Adjustment Percentage:     3%	  	

  

			
	Base Term:	  	Beginning on the Commencement Date and ending, subject to the terms Section 40 hereof, 60 months from the first day of the first full month of the Term (as defined in Section 2) hereof. For clarity, if the
Commencement Date occurs on the first day of a month, the Base Term shall be measured from that date. If the Commencement Date occurs on a day other than the first day of a month, the Base Term shall be measured from the first day of the following
month.
		
	Permitted Use:	  	Research and development laboratory, related office and other related uses consistent with the character of the Project and otherwise in compliance with the provisions of Section 7 hereof.

  

			
	Address for Rent Payment:	  	Landlord’s Notice Address:
	 Alexandria Real Estate Equities, Inc.
 Dept LA
23447
 Pasadena, CA 91185-3447
	  	 385 E. Colorado Boulevard, Suite 299

Pasadena, CA 91101
 Attention: Corporate Secretary

		
	Tenant’s Notice Address:	  	
	 180 North LaSalle Street, Suite 1800 Chicago,

Illinois 60601 Attn: Steve Pieper
	  	

  
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 The following Exhibits and Addenda are attached hereto and incorporated herein by this reference:

  

			
	☒ EXHIBIT A - PREMISES DESCRIPTION	  	☒ EXHIBIT B - DESCRIPTION OF PROJECT
	☒ EXHIBIT C - WORK LETTER	  	☒ EXHIBIT D - COMMENCEMENT DATE
	☒ EXHIBIT E - RULES AND REGULATIONS	  	☒ EXHIBIT F - TENANT’S PERSONAL PROPERTY
	☒ EXHIBIT G - MAINTENANCE OBLIGATIONS	  	☒ EXHIBIT H - ASBESTOS DISCLOSURE

  
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 1. Lease of Premises. Upon and subject to all of the terms and
conditions hereof, Landlord hereby leases the Premises to Tenant and Tenant hereby leases the Premises from Landlord. The portions of the Project which are for the non-exclusive use of tenants of the Project are collectively referred to herein as
the “Common Areas.” Landlord reserves the right to modify Common Areas, provided that such modifications do not materially adversely affect Tenant’s access to (other than on a temporary basis) or use of the Premises for the
Permitted Use or Tenant’s parking rights hereunder (other than on a temporary basis). From and after the Commencement Date through the expiration of the Term, Tenant shall have access to the Building, the Premises and the parking areas serving
the Project 24 hours a day, 7 days a week, except in the case of emergencies, as the result of Legal Requirements, the performance by Landlord of any installation, maintenance or repairs, or any other temporary interruptions, and otherwise subject
to the terms of this Lease. 
 2. Delivery; Acceptance of Premises; Commencement Date. Landlord shall use reasonable efforts
to deliver the Premises to Tenant on or before the Target Commencement Date, with Landlord’s Work Substantially Completed (“Delivery” or “Deliver”). If Landlord fails to timely Deliver the Premises, Landlord
shall not be liable to Tenant for any loss or damage resulting therefrom, and this Lease shall not be void or voidable except as provided herein. If Landlord does not Deliver the Premises within 90 days of the Target Commencement Date for any reason
other than Force Majeure delays and Tenant Delays, this Lease may be terminated by Tenant by written notice to Landlord, and if so terminated by Tenant: (a) the Security Deposit, or any balance thereof (i.e., after deducting therefrom all
amounts to which Landlord is entitled under the provisions of this Lease), and any prepaid Base Rent shall be returned to Tenant within 30 days thereafter, and (b) neither Landlord nor Tenant shall have any further rights, duties or obligations
under this Lease, except with respect to provisions which expressly survive termination of this Lease. As used herein, the terms “Landlord’s Work,” “Tenant Delays” and “Substantially Completed”
shall have the meanings set forth for such terms in the Work Letter. If Tenant does not elect to void this Lease within 10 business days of the lapse of such 90 day period, such right to void this Lease shall be waived and this Lease shall remain in
full force and effect. 
 The “Commencement Date” shall be the earlier of: (i) the date Landlord Delivers the Premises
to Tenant; and (ii) the date Landlord could have Delivered the Premises but for Tenant Delays. Upon the request of either Landlord or Tenant, Landlord and Tenant shall execute and deliver a written acknowledgment of the Commencement Date, and
the expiration date of the Term when such are established in the form of the “Acknowledgement of Commencement Date” attached to this Lease as Exhibit D; provided, however, the failure by either party to execute and
deliver such acknowledgment shall not affect either party’s rights hereunder. The “Term” of this Lease shall be the Base Term, as defined above on the first page of this Lease and, if elected by Tenant, the Extension Term which
Tenant may elect pursuant to Section 39 hereof. 
 Except as set forth in the Work Letter or as otherwise expressly set forth in
this Lease: (i) Tenant shall accept the Premises in their condition as of the Commencement Date; (ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking possession of the Premises shall
be conclusive evidence that Tenant accepts the Premises and that the Premises were in good condition at the time possession was taken. 

For the period of 30 consecutive days after the Commencement Date, Landlord shall, at its sole cost and expense (which shall not constitute an
Operating Expense), be responsible for any repairs that are required to be made to the Building Systems (as defined in Section 13) serving the Premises, unless Tenant or any Tenant Party was responsible for the cause of such repair, in
which case Tenant shall pay the cost. 

  
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 Subject to the provisions of Section 6 of the Work Letter, Landlord shall permit
Tenant access to the Premises for a period of 30 days prior to the Commencement Date for Tenant’s installation and setup of furniture, fixtures and equipment (“FF&E Installation”), provided that such FF&E Installation
is coordinated with Landlord, and Tenant complies with the Lease and all other reasonable restrictions and conditions Landlord may impose. All such access shall be during normal business hours. Any access to the Premises by Tenant before the
Commencement Date shall be subject to all of the terms and conditions of this Lease, excluding the obligation to pay Base Rent or Operating Expenses. 

Tenant agrees and acknowledges that, except as otherwise expressly provided in this Lease, neither Landlord nor any agent of Landlord has made
any representation or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied
warranty that the Premises or the Project are suitable for the Permitted Use. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations,
inducements, promises, agreements, understandings and negotiations which are not contained herein. Landlord in executing this Lease does so in reliance upon Tenant’s representations, warranties, acknowledgments and agreements contained herein.

 3. Rent. 

(a) Base Rent. The first month’s Base Rent shall be due and payable on delivery of an executed copy of this Lease to
Landlord. The Security Deposit shall be due on the date that is 5 days after the mutual execution and delivery of this Lease by the parties. Tenant shall pay to Landlord in advance, without demand, abatement, deduction or set-off, monthly
installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office of Landlord for payment of Rent set forth above, or to such other person or at such
other place as Landlord may from time to time designate in writing. Payments of Base Rent for any fractional calendar month shall be prorated. The obligation of Tenant to pay Base Rent and other sums to Landlord and the obligations of Landlord under
this Lease are independent obligations. Tenant shall have no right at any time to abate, reduce, or set-off any Rent (as defined in Section 5) due hereunder except for any abatement as may be expressly provided in this Lease. 

Notwithstanding anything to the contrary contain herein, so long as Tenant is not in Default under this Lease, for the period commencing on
the Commencement Date through the last day of the 30th full month after the Commencement Date (the “Partial Abatement Period”), Tenant shall only be required to pay Base Rent with
respect to 11,000 rentable square feet of the Premises. Commencing on the first day of the 31st full month after the Commencement Date, Tenant shall commence paying Base Rent with respect to the
entire Premises. 
 (b) Additional Rent. In addition to Base Rent, Tenant agrees to pay to Landlord as additional rent
(“Additional Rent”): (i) commencing on the Commencement Date, Tenant’s Share of “Operating Expenses” (as defined in Section 5). and (ii) any and all other amounts Tenant assumes or agrees to pay
under the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of this Lease to be performed
by Tenant, after any applicable notice and cure period. 

  
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 4. Base Rent Adjustments. Base Rent shall be increased on each annual anniversary
of the first day of the first full month during the Term of this Lease (each an “Adjustment Date”) by multiplying the Base Rent payable immediately before such Adjustment Date by the Rent Adjustment Percentage and adding the
resulting amount to the Base Rent payable immediately before such Adjustment Date. Base Rent, as so adjusted, shall thereafter be due as provided herein. Base Rent adjustments for any fractional calendar month shall be prorated. 

5. Operating Expense Payments. Landlord shall deliver to Tenant, not later than April 1st of each calendar year, a written estimate of Operating Expenses for such calendar year during the Term (the “Annual Estimate”), which may be revised by Landlord from time to time
during such calendar year. Commencing on the Commencement Date and continuing thereafter on the first day of each month during the Term, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for
any fractional calendar month shall be prorated. 
 Notwithstanding anything to the contrary contained herein, during the Partial Abatement
Period, so long as Tenant is not in Default under this Lease, other than with respect to Utilities (as defined in Section H) provided to the Premises which Tenant shall pay with respect to the entire Premises commencing on the Commencement
Date, Tenant shall only be required to pay Operating Expenses (including the administration rent provided for below) with respect to 11,000 rentable square feet of the Premises (i.e., Tenant Share of Operating Expenses shall be equal to 19.63%).
Commencing on the first day of the 31st month after the Commencement Date, Tenant shall commence paying Operating Expenses (including the administration rent) with respect to the entire Premises.

 The term “Operating Expenses” means all costs and expenses of any kind or description whatsoever incurred or accrued
each calendar year during the Term by Landlord with respect to the Project (including, without duplication, Taxes (as defined in Section 9). capital repairs and improvements amortized over the lesser of 10 years and the useful life of
such capital items, and the costs of Landlord’s third party property manager or, if there is no third party property manager, administration rent in the amount of 3.0% of Base Rent), excluding only the following: 

(a) the original construction costs of the Project and renovation prior to the date of the Lease and costs of correcting defects in such
original construction or renovation; 
 (b) capital expenditures for expansion of the Project including, without limitation, the original
costs incurred (i) to construct another building at the Project, (ii) to expand the Building, or (iii) to construct a bridge or walkway to connect the Building with any other building at the Project; 

(c) interest, principal payments of Mortgage (as defined in Section 27) debts of Landlord, financing costs and amortization
of funds borrowed by Landlord, whether secured or unsecured, and all payments of rent (but not taxes or operating expenses) under any ground lease or other underlying lease of all or any portion of the Project; 

  
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 (d) depreciation of the Project (except for capital improvements, the cost of which are
includable in Operating Expenses); 
 (e) advertising, marketing, solicitation, legal and space planning expenses and leasing commissions
and other costs and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants; 

(f) legal and other expenses incurred in the negotiation or enforcement of leases; 

(g) completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or performs for other tenants
within their premises, and costs of correcting defects in such work; 
 (h) costs to be reimbursed by other tenants of the Project or Taxes
to be paid directly by Tenant or other tenants of the Project, whether or not actually paid; 
 (i) salaries, wages, benefits and other
compensation paid to (i) personnel of Landlord or its agents or contractors above the position of the person, regardless of title, who has day-to-day management responsibility for the Project or (ii) officers and employees of Landlord or
its affiliates who are not assigned in whole or in part to the operation, management, maintenance or repair of the Project; provided, however, that with respect to any such person who does not devote substantially all of his or her employed time to
the Project, the salaries, wages, benefits and other compensation of such person shall be prorated to reflect time spent on matters related to operating, managing, maintaining or repairing the Project in comparison to the time spent on matters
unrelated to operating, managing, maintaining or repairing the Project; 
 (j) general organizational, administrative and overhead costs
relating to maintaining Landlord’s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(k) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with
disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or
mortgagees of the Building; 
 (l) costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors or any
tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 7); 

(m) penalties, fines or interest incurred as a result of Landlord’s inability or failure to make payment of Taxes and/or to file any tax
or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(n) overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the Project
to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 

  
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 (o) costs, fees, dues, contributions or similar expenses for Landlord’s charitable or
political contributions, or for sculptures, paintings, fountains or other objects of fine art maintained at the Project; 
 (p) costs in
connection with services (including electricity), items or other benefits of a type which are not standard for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant
of the Project, whether or not such other tenant or occupant is specifically charged therefor by Landlord; 
 (q) costs incurred in the sale
or refinancing of the Project; 
 (r) net income taxes of Landlord or the owner of any interest in the Project, franchise, capital stock,
gift, estate or inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; 

(s) any costs, fees, dues, contributions or similar expenses for political, charitable, industry association or similar organizations, as well
as the cost of any newspaper, magazine, trade or other subscriptions, excepting the Building’s/Project’s annual membership dues in the local Building Owners and Managers Association; 

(t) rentals and other related expenses incurred for systems or equipment, the cost of which if purchased would be required under the other
terms of this Lease to be excluded from Operating Expenses as a capital cost, excepting from this exclusion equipment not affixed to the Project which is used in providing janitorial or similar services and, further excepting from this exclusion
such equipment rented or leased to remedy or ameliorate an emergency condition at the Project; 
 (u) any cost of any service or items made
available to tenants or other occupants at the Project other than Tenant for which Landlord or Landlord’s managing agent has been or is entitled to be reimbursed by such tenants or other occupants for such service or has been reimbursed by
insurance or otherwise compensated by parties other than tenants of the Project to include replacement of any item to the extent covered by a warranty; 

(v) fines, costs, late charges, liquidated damages, penalties, tax penalties or related interest charges imposed on Landlord or
Landlord’s managing agent for failure by Landlord to comply with Legal Requirements except to the extent attributable to any acts or omissions of Tenant or any Tenant Party; 

(w) commercial concessions operated at the Project by or on behalf of the Landlord; 

(x) any flowers, gifts, balloons, etc. provided to any entity including, but not limited to, Tenant, other tenants, employees, vendors,
contractors, prospective tenants and agents; 
 (y) interest reserves or reserves of any kind; 

  
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 (z) any cost incurred in or properly attributable to a year prior to the year in which the
Commencement Date occurs, including, but not limited to, amortization of capital expenditures and real estate taxes incurred for prior years but billed and paid after the Commencement Date; 

(aa) any costs incurred to remove, study, test or remediate Hazardous Materials in or about the Premises, the Building or the Project for
which Tenant is not responsible under Section 30 hereof; and 
 (bb) any expenses otherwise includable within Operating Expenses
to the extent actually reimbursed by persons other than tenants of the Project under leases for space in the Project. 
 In addition,
notwithstanding anything to the contrary contained in this Lease, Operating Expenses incurred or accrued by Landlord with respect to any capital improvements which are reasonably expected by Landlord to reduce overall Operating Expenses (for
example, without limitation, by reducing energy usage at the Project) (the “Energy Savings Costs”) shall be amortized over a period of years equal to the least of (A) 7 years, (B) the useful life of such capital items, or
(C) the quotient of (i) the Energy Savings Costs, divided by (ii) the annual amount of Operating Expenses reasonably expected by Landlord to be saved as a result of such capital improvements. 

Following the date that is 18 months after Landlord’s delivery of an Annual Statement (as defined below) to Tenant, Tenant shall not be
responsible for the payment of items of Operating Expenses not reflected in such Annual Statement, except for Taxes for which Tenant is responsible under this Lease and/or any costs for which Landlord is billed after the expiration of such 18 month
period. 
 Within 90 days after the end of each calendar year (or such longer period as may be reasonably required), Landlord shall furnish
to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual Operating Expenses for the previous calendar year, and (b) the total of Tenant’s payments in
respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of Operating Expenses for such year, the excess shall be due and payable by Tenant as Rent within 30 days
after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of actual Operating Expenses for such year Landlord shall pay the excess to Tenant within 30 days after
delivery of such Annual Statement, except that after the expiration, or earlier termination of the Term or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord.
Landlord’s and Tenant’s obligations to pay any overpayments or deficiencies due pursuant to this paragraph shall survive the expiration or earlier termination of this Lease. 

The Annual Statement shall be final and binding upon Tenant unless Tenant, within 90 days after Tenant’s receipt thereof, shall contest
any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 90 day period, Tenant reasonably and in good faith questions or contests the accuracy of Landlord’s statement of
Tenant’s Share of Operating Expenses, Landlord will provide Tenant with access to Landlord’s books and records relating to the operation of the Project, Landlord’s calculation of Operating Expenses and such other information
reasonably requested by Tenant relating thereto (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of

  
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Tenant’s Share of Operating Expenses, then Tenant shall have the right to have an independent public accounting firm selected by Tenant from among the 4 largest in the United States, working
pursuant to a fee arrangement other than a contingent fee (at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld, conditioned or delayed), audit and/or review the Expense Information for
the year in question (the “Independent Review”). The results of any such Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the payments actually made by Tenant with respect to Operating
Expenses for the calendar year in question exceeded Tenant’s Share of Operating Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated
Operating Expenses or (ii) pay the excess to Tenant within 30 days after delivery of such statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall
pay the excess to Tenant after deducting all other amounts due Landlord. If the Independent Review shows that Tenant’s payments with respect to Operating Expenses for such calendar year were less than Tenant’s Share of Operating Expenses
for the calendar year, Tenant shall pay the deficiency to Landlord within 30 days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with respect to Operating Expenses by more than 5% then Landlord shall
reimburse Tenant for all costs incurred by Tenant for the Independent Review. Operating Expenses for the calendar years in which Tenant’s obligation to share therein begins and ends shall be prorated. Notwithstanding anything set forth herein
to the contrary, if the Project is not at least 95% occupied on average during any year of the Term, Tenant’s Share of Operating Expenses for such year shall be computed as though the Project had been 95% occupied on average during such year.

 “Tenant’s Share” shall be the percentage set forth on the first page of this Lease as Tenant’s Share as
reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. To the extent that Landlord has a reasonable basis for doing so, Landlord may increase on an equitable and reasonable basis
Tenant’s Share for any item of expense or cost reimbursable by Tenant that relates to a repair, replacement, or service that benefits only the Premises or only a portion of the Project that includes the Premises or that varies with occupancy or
use. Base Rent, Tenant’s Share of Operating Expenses and all other amounts payable by Tenant to Landlord hereunder are collectively referred to herein as “Rent.” 

6. Security Deposit. Tenant shall deposit with Landlord, within 5 days after the mutual execution and delivery of this Lease by the
parties, a security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth on page 1 of this Lease, which Security Deposit shall be in the form of an unconditional
and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance reasonably satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw upon it at any
time from time to time by delivering to the issuer notice that Landlord Is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution reasonably satisfactory to Landlord, and (v) redeemable by presentation of a sight
draft in the State of California. If Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before the stated expiration date of any then current Letter of Credit, Landlord
shall have the right to draw the full amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit. The Security Deposit shall be held by Landlord as security for the
performance of Tenant’s obligations under this Lease. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default. Upon each occurrence of a Default (as defined in
Section 20), Landlord may use all or any part of the Security Deposit to pay delinquent 

  
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payments due under this Lease, future rent damages under California Civil Code Section 1951.2, and the cost of any damage, injury, expense or liability caused by such Default, without
prejudice to any other remedy provided herein or provided by law. Landlord’s right to use the Security Deposit under this Section 6 includes the right to use the Security Deposit to pay future rent damages following the termination
of this Lease pursuant to Section 21(c) below. Upon any use of all or any portion of the Security Deposit, Tenant shall pay Landlord on demand the amount that will restore the Security Deposit to the amount set forth on Page 1 of this
Lease. Tenant hereby waives the provisions of any law, now or hereafter in force, including, without limitation, California Civil Code Section 1950.7, which provide that Landlord may claim from a security deposit only those sums reasonably
necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other loss or
damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any officer, employee, agent or invitee of Tenant. Upon bankruptcy or other debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be
applied first to the payment of Rent and other charges due Landlord for periods prior to the filing of such proceedings. If Tenant shall fully perform every provision of this Lease to be performed by Tenant, the Security Deposit, or any balance
thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within 60
days after the expiration or earlier termination of this Lease. 
 If Landlord transfers its interest in the Project or this Lease, Landlord
shall either (a) transfer any Security Deposit then held by Landlord to a person or entity assuming in writing Landlord’s obligations under this Section 6. or (b) return to Tenant any Security Deposit then held by Landlord
and remaining after the deductions permitted herein. Upon such transfer to such transferee or the return of the Security Deposit to Tenant, Landlord shall have no further obligation with respect to the Security Deposit, and Tenant’s right to
the return of the Security Deposit shall apply solely against Landlord’s transferee. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default. Landlord’s obligation
respecting the Security Deposit is that of a debtor, not a trustee, and no interest shall accrue thereon. 
 7. Use. The Premises
shall be used solely for the Permitted Use set forth in the basic lease provisions on page 1 of this Lease, and in compliance with all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions
now or hereafter applicable to the Premises, and to the use and occupancy thereof, including, without limitation, the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto,
“ADA”) (collectively, “Legal Requirements” and each, a “Legal Requirement”). Tenant shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by
any Governmental Authority (as defined in Section 9) having jurisdiction to be a violation of a Legal Requirement Tenant will not use or permit the Premises to be used for any purpose or in any manner that would void Tenant’s or
Landlord’s insurance, increase the insurance risk, or cause the disallowance of any sprinkler or other credits. Tenant shall not permit any part of the Premises to be used as a “place of public accommodation”, as defined in the ADA or
any similar legal requirement. Tenant shall reimburse Landlord promptly upon demand for any additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused
by Tenant’s particular use and/or occupancy of the Premises. Tenant will use the Premises in a careful, safe and proper manner and will not commit or permit waste, overload the floor or 

  
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structure of the Premises, subject the Premises to use that is reasonably likely to damage to the Premises or obstruct or interfere with the rights of Landlord or other tenants or occupants of
the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful purpose. Tenant shall cause any equipment or machinery to be
installed in the Premises so as to reasonably prevent sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not place any machinery or equipment weighing 500 pounds or more in or upon
the Premises or transport or move such items through the Common Areas of the Project or in the Project elevators without the prior written consent of Landlord. Except as may be provided under the Work Letter, Tenant shall not, without the prior
written consent of Landlord, use the Premises in any manner which will require ventilation, air exchange, heating, gas, steam, electricity or water beyond the existing capacity of the Project as proportionately allocated to the Premises based upon
Tenant’s Share (as set forth on Page 1 without adjustment pursuant to Section 5) as usually furnished for the Permitted Use. 

Landlord shall be responsible, at Landlord’s cost and not as part of Operating Expenses, for the compliance of the Premises and the
Common Areas of the Project with Legal Requirements as of the Commencement Date. Following the Commencement Date, Landlord shall, as an Operating Expense (to the extent such Legal Requirement is generally applicable to similar buildings in the area
in which the Project is located) and at Tenant’s expense (to the extent such Legal Requirement is triggered by reason of Tenant’s, as compared to other tenants of the Project, particular use of the Premises or Tenant’s Alterations)
make any alterations or modifications to the Common Areas or the exterior of the Building that are required by Legal Requirements. Except as provided in the 2 immediately preceding sentences, Tenant, at its sole expense, shall make any alterations
or modifications to the interior of the Premises that are required by Legal Requirements (including, without limitation, compliance of the Premises with the ADA) related to Tenant’s particular use or occupancy of the Premises. Notwithstanding
any other provision herein to the contrary, Tenant shall be responsible for any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and ail reasonable expenses incurred in investigating or
resisting the same (including, without limitation, reasonable attorneys’ fees, charges and disbursements and costs of suit) (collectively, “Claims”) arising out of or in connection with Legal Requirements related to
Tenant’s particular use or occupancy of the Premises or Tenant’s Alterations (not including the Tenant Improvements (as defined in the Work Letter) constructed pursuant to the Work Letter), and Tenant shall indemnify, defend, hold and save
Landlord harmless from and against any and all Claims arising out of or in connection with any failure of the Premises to comply with any Legal Requirement related to Tenant’s particular use or occupancy of the Premises or Tenant’s
Alterations (not including the Tenant Improvements constructed pursuant to the Work Letter). 
 Tenant acknowledges that Landlord may, but
shall not be obligated to, seek to obtain Leadership in Energy and Environmental Design (LEED), WELL Building Standard, or other similar “green” certification with respect to the Project and/or the Premises, and Tenant agrees, at no
material cost to Tenant, to reasonably cooperate with Landlord, and to provide such information and/or documentation as Landlord may reasonably request, in connection therewith. 

8. Holding Over. If, with Landlord’s express written consent, Tenant retains possession of the Premises after the termination of
the Term, (i) unless otherwise agreed in such written consent, such possession shall be subject to immediate termination by Landlord at any time, (ii) all of the other terms and provisions of this Lease (including, without limitation, the
adjustment of Base Rent pursuant to Section 4 hereof) shall remain in full force and effect (excluding any expansion or renewal option or other similar right or option) 

  
 11 

 
during such holdover period, (iii) Tenant shall continue to pay Base Rent in the amount payable upon the date of the expiration or earlier termination of this Lease or such other amount as
Landlord and Tenant may agree in such written consent, and (iv) all other payments shall continue under the terms of this Lease. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without the
express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Rent in effect during the last 30 days of the Term, and (B) Tenant
shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages; provided, however, that if Tenant delivers a written inquiry to Landlord within 30 days prior to
the expiration or earlier termination of the Term, Landlord will notify Tenant whether the potential exists for consequential damages. No holding over by Tenant, whether with or without consent of Landlord, shall operate to extend this Lease except
as otherwise expressly provided, and this Section 8 shall not be construed as consent for Tenant to retain possession of the Premises. Acceptance by Landlord of Rent after the expiration of the Term or earlier termination of this Lease
shall not result in a renewal or reinstatement of this Lease. 
 9. Taxes. Landlord shall pay, as part of Operating Expenses,
all real property taxes, levies, fees, assessments and governmental charges of any kind, existing as of the Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed on the Project by any federal, state,
regional, municipal, local or other governmental authority or agency, including, without limitation, quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes;
(i) imposed on or measured by or based, in whole or in part, on rent payable to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square
footage, assessed value or other measure or evaluation of any kind of the Premises or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises or the Project, including parking, or
(iv) assessed or imposed by, or at the direction of, or resulting from Legal Requirements, or interpretations thereof, promulgated by any Governmental Authority, or (v) imposed as a license or other fee, charge, tax, or assessment on
Landlord’s business or occupation of leasing space in the Project. Landlord may contest by appropriate legal proceedings the amount, validity, or application of any Taxes or liens securing Taxes. Taxes shall not include any net income taxes,
franchise, estate, inheritance, succession, capital levy, transfer or excess profits taxes imposed on Landlord except to the extent such net income taxes are in substitution for any Taxes payable hereunder. If any such Tax is levied or assessed
directly against Tenant, then Tenant shall be responsible for and shall pay for Tenant’s Share of the same at such times and in such manner as the taxing authority shall require. Tenant shall pay, prior to delinquency, any and all Taxes levied
or assessed against any personal property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on Tenant’s personal property or trade fixtures are levied against Landlord or
Landlord’s property, or if the assessed valuation of the Project is increased by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real property so as
to become a part thereof, higher than the base valuation on which Landlord from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s reasonable
determination of any excess assessed valuation shall be binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due from Tenant to Landlord immediately upon demand. 

  
 12 

 10. Parking. Subject to all applicable Legal Requirements, Force Majeure, a Taking
(as defined in and governed by Section 19 below) and the exercise by Landlord of its rights hereunder, Tenant shall have the right, at no additional charge during the Base Term, in common with other tenants of the Project to use 2.5
parking spaces per 1,000 rentable square feet of the Premises, in those areas designated for non-reserved parking, subject in each case to Landlord’s reasonable and non-discriminatory rules and regulations. Four (4) of the parking spaces
which Tenant is entitled to use pursuant to the first sentence of this Section 10, which shall be located in front of the Premises and otherwise in a location determined by Landlord, shall be marked as reserved for Tenant and its
visitors. Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including other tenants of the Project, or for enforcing any reservation of parking spaces. 

11. Utilities, Services. Landlord shall provide, subject to the terms of this Section 11. water, electricity, heat,
light, power, sewer, and other utilities (including gas and fire sprinklers to the extent the Project is plumbed for such services) to the Premises and the Project, and, with respect to the Common Areas only, refuse and trash collection and
janitorial services (collectively, “Utilities”). Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all Utilities used on the Premises, all maintenance charges for Utilities, and any
storm sewer charges or other similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar charges thereon. Landlord may cause any Utilities to be separately metered or
charged directly to Tenant by the provider. Tenant shall pay directly to the Utility provider, prior to delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant shall pay, as
part of Operating Expenses, its share of all charges for jointly metered Utilities based upon consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever other than Landlord’s willful
misconduct, shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use. Tenant shall be
responsible for obtaining and paying for its own refuse and trash collection services and janitorial services for the Premises. 

Notwithstanding anything to the contrary set forth herein, if (i) a stoppage of an Essential Service (as defined below) to the Premises
shall occur and such stoppage is due solely to the gross negligence or willful misconduct of Landlord and not due in any part to any act or omission on the part of Tenant or any Tenant Party or any matter beyond Landlord’s reasonable control
(any such stoppage of an Essential Service being hereinafter referred to as a “Service Interruption”), and (ii) such Service Interruption continues for more than 5 consecutive business days after Landlord shall have received
written notice thereof from Tenant, and (iii) as a result of such Service Interruption, the conduct of Tenant’s normal operations in the Premises are materially and adversely affected, then, there shall be an abatement of one day’s
Base Rent for each day during which such Service Interruption continues after such 5 business day period; provided, however, that if any part of the Premises is reasonably useable for Tenant’s normal business operations or if Tenant conducts
all or any part of its operations in any portion of the Premises notwithstanding such Service Interruption, then the amount of each daily abatement of Base Rent shall only be proportionate to the nature and extent of the interruption of
Tenant’s normal operations or ability to use the Premises. The rights granted to Tenant under this paragraph shall be Tenant’s sole and exclusive remedy resulting from a failure of Landlord to provide services, and Landlord shall not
otherwise be liable for any loss or damage suffered or sustained by Tenant resulting from any failure or cessation of services. For purposes hereof, the term “Essential Services” shall mean the following services: HVAC service,
water, sewer and electricity, but in each case only to the extent that Landlord has an obligation to provide 

  
 13 

 
same to Tenant under this Lease. The provisions of this paragraph shall only apply as long as the original Tenant is the tenant occupying the Premises under this Lease and shall not apply to any
assignee or sublessee. 
 Tenant agrees to provide Landlord with reasonable access to Tenant’s water and/or energy usage data on a
monthly basis, either by providing Tenant’s applicable utility login credentials to Landlord’s Measurable online portal, or by another delivery method reasonably agreed to by Landlord and Tenant. The costs and expenses incurred by Landlord
in connection with receiving and analyzing such water and/or energy usage data (including, without limitation, as may be required pursuant to applicable Legal Requirements) shall be included as part of Operating Expenses. 

12. Alterations and Tenant’s Property. Any alterations, additions, or improvements made to the Premises by or on behalf of
Tenant, including additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but excluding installation, removal or realignment of furniture systems (other than removal of furniture systems owned or paid for by
Landlord) not involving any modifications to the structure or connections (other than by ordinary plugs or jacks) to Building Systems (as defined in Section 13) (“Alterations”) shall be subject to Landlord’s prior
written consent, which may be given or withheld in Landlord’s sole discretion if any such Alteration affects the structure or Building Systems and shall not be otherwise unreasonably withheld. If Landlord approves any Alterations, Landlord may
impose such reasonable conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s reasonable discretion. Any request for approval shall be in writing,
delivered not less than 15 business days in advance of any proposed construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the alterations as may be
reasonably requested by Landlord, including the identities and mailing addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own
benefit, and Landlord shall have no duty to ensure that such plans and specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements
and with Legal Requirements and shall implement at its sole cost and expense any alteration or modification required by Legal Requirements as a result of any Alterations. Tenant shall pay to Landlord, as Additional Rent, on demand an amount equal to
1 % of all charges incurred by Tenant or its contractors or agents in connection with any Alteration to cover Landlord’s overhead and expenses for plan review, coordination, scheduling and supervision. Before Tenant begins any Alteration,
Landlord may post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done
by Tenant or its contractors, delays caused by such work, or inadequate cleanup. 
 Tenant shall furnish security or make other arrangements
satisfactory to Landlord to assure payment for the completion of all Alterations work free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and
other coverage in amounts and from an insurance company satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations, Tenant shall deliver to Landlord:
(I) certified statements setting forth the names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for any such Alteration. 

  
 14 

 Except for Removable Installations (as hereinafter defined), all Installations (as hereinafter
defined) shall be and shall remain the property of Landlord during the Term and following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term, and shall remain upon and be surrendered with
the Premises as a part thereof. Notwithstanding the foregoing, Landlord may, at the time its approval of any such Installation is requested, notify Tenant that Landlord requires that Tenant remove such Installation upon the expiration or earlier
termination of the Term, in which event Tenant shall remove such Installation in accordance with the immediately succeeding sentence. Upon the expiration or earlier termination of the Term, Tenant shall remove (i) all wires, cables or similar
equipment which Tenant has installed in the Premises or in the risers or plenums of the Building, (ii) any Installations for which Landlord has given Tenant notice of removal in accordance with the immediately preceding sentence, and
(iii) all of Tenant’s Property (as hereinafter defined), and Tenant shall restore and repair any damage caused by or occasioned as a result of such removal, including, without limitation, capping off all such connections behind the walls
of the Premises and repairing any holes. During any restoration period beyond the expiration or earlier termination of the Term, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. 

Subject to the provisions of this paragraph, during the Term, Landlord waives any statutory landlord’s lien and any attachment for Rent
on Tenant’s Property and on any Alteration of Tenant that is not required to be surrendered to Landlord at the expiration or sooner termination of the Term of this Lease (collectively, “Personalty”) that Landlord may have or
may hereafter acquire. Landlord acknowledges and agrees that Tenant’s Personalty may be leased from an equipment lessor or encumbered by Tenant’s lender (collectively, “Equipment Lessor”) and that Tenant may execute and
enter into an equipment lease or security agreement with respect to such Personalty (“Equipment Lease”). If and to the extent required by any Equipment Lease or Equipment Lessor, Landlord shall execute and deliver to the Equipment
Lessor a written consent, waiver and/or acknowledgment which is in form and content reasonably acceptable to Landlord (“Lien Waiver”) in which Landlord (i) acknowledges and agrees that, during the Term, the Personalty which is
the subject of the Equipment Lease and described with specificity on an exhibit to the Lien Waiver constitutes the personal property of Tenant (unless contrary to the provisions of this Lease), and shall not be considered to be part of the Premises,
regardless of whether or by what means they become attached thereto, (ii) agrees that, during the Term, it shall not claim any interest in such Personalty, and (iii) agrees that Equipment Lessor may enter the Premises for the purpose of
removing such Personalty, but only if, in such consent such Equipment Lessor agrees to repair any damage resulting from such removal and to indemnify and hold harmless Landlord from and against any claim or other loss that results from such entry
and, agrees, within 3 business days after the expiration or termination of the Term to pay all Rent that would accrue under the Lease if it had not terminated or expired for the period from the expiration or termination of such Lease until 5
business days after such Equipment Lessor relinquishes its right rights to enter into the Premises; provided, further, such Equipment Lessor’s right to enter the Premises shall in any event expire 30 days after the expiration or termination of
the Lease in which case the Equipment Lessor and Tenant shall agree that the Personalty shall be deemed abandoned. Such Lien Waiver documents also may contain such other reasonable and customary provisions that are reasonably acceptable to Landlord.
Landlord shall be entitled to be paid as administrative rent a fee of $1,000 per occurrence for its time and effort in preparing and negotiating each Lien Waiver. 

  
 15 

 For purposes of this Lease, (x) “Removable Installations” means any items
listed on Exhibit F attached hereto and any items agreed by Landlord in writing to be included on Exhibit F in the future, (y) “Tenant’s Property” means Removable Installations and, other than Installations,
any personal property or equipment of Tenant that may be removed without material damage to the Premises, and (z) “Installations” means all property of any kind paid for with the Tl Fund, all Alterations, all fixtures, and all
partitions, hardware, built-in machinery, built-in casework and cabinets and other similar additions, equipment, property and improvements built into the Premises so as to become an integral part of the Premises, including, without limitation, fume
hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms, walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment, autoclaves, chillers, built-in plumbing, electrical and mechanical
equipment and systems, and any power generator and transfer switch. 
 Tenant shall not be required to remove the Tenant Improvements
constructed pursuant to the Work Letter at the expiration or earlier termination of the Term of this Lease nor shall Tenant have the right to remove any of the Tenant Improvements at any time prior to the expiration or earlier termination of the
Term. 
 13. Landlord’s Repairs. Landlord shall, at Landlord’s sole expense (and not as an Operating Expense), be
responsible for capital repairs and replacements of the roof (not including the roof membrane), exterior walls and foundation of the Building (“Structural Items”) unless the need for such repairs or replacements is caused by Tenant
or any Tenant Parties, in which case Tenant shall bear the full cost to repair or replace such Structural Items. Landlord shall, as an Operating Expense, be responsible for the routine maintenance and repair of such Structural Items. Landlord, as an
Operating Expense, shall maintain, repair and replace the roof membrane and all of the exterior, parking and other Common Areas of the Project, including HVAC, plumbing, fire sprinklers and all other building systems serving the Premises and other
portions of the Project (“Building Systems”), in good repair, reasonable wear and tear and uninsured losses and damages caused by Tenant, or by any of Tenant, or by any of Tenant’s assignees, sublessees, licensees, agents,
servants, employees, invitees and contractors (or any of Tenant’s assignees, sublessees and/or licensees respective agents, servants, employees, invitees and contractors) (collectively, “Tenant Parties”) excluded. Losses and
damages caused by Tenant or any Tenant Party shall be repaired by Landlord, to the extent not covered by insurance, at Tenant’s sole cost and expense. Landlord reserves the right to stop Building Systems services when necessary (i) by
reason of accident or emergency, or (ii) for planned repairs, alterations or improvements, which are, in the judgment of Landlord, desirable or necessary to be made, until said repairs, alterations or improvements shall have been completed.
Landlord shall have no responsibility or liability for failure to supply Building Systems services during any such period of interruption; provided, however, that Landlord shall, except in case of emergency, give Tenant at least 2
business days’ advance notice of any planned stoppage of Building Systems services for routine maintenance, repairs, alterations or improvements. Tenant shall promptly give Landlord written notice of any repair required by Landlord pursuant to
this Section, after which Landlord shall make a commercially reasonable effort to effect such repair. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance unless such failure shall persist for an
unreasonable time after Tenant’s written notice of the need for such repairs or maintenance. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at Landlord’s expense and agrees that the
parties’ respective rights with respect to such matters shall be solely as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of damage or destruction shall be controlled by
Section 18. 

  
 16 

 Notwithstanding anything to the contrary contained in this Lease, as of the Commencement Date,
the maintenance and repair obligations for the Premises shall be allocated between Landlord and Tenant as set forth on Exhibit G attached hereto. The maintenance obligations allocated to Tenant pursuant to Exhibit G (the
“Tenant Maintenance Obligations”) shall be performed by Tenant at Tenant’s sole cost and expense. The Tenant Maintenance Obligations shall include the procurement and maintenance of contracts, in form and substance reasonably
satisfactory to Landlord, with copies to Landlord upon Landlord’s written request, for and with contractors reasonably acceptable to Landlord specializing and experienced in the respective Tenant Maintenance Obligations. Notwithstanding
anything to the contrary contained herein, the scope of work of any such contracts entered into by Tenant pursuant to this paragraph shall, at a minimum, comply with manufacturer’s recommended maintenance procedures for the optimal performance
of the applicable equipment. Landlord shall, notwithstanding anything to the contrary contained in this Lease, have no obligation to perform any Tenant Maintenance Obligations. The Tenant Maintenance Obligations shall not include the right or
obligation on the part of Tenant to make any structural and/or capital repairs or improvements to the Project, and Landlord shall, during any period that Tenant is responsible for the Tenant Maintenance Obligations, continue, as part of Operating
Expenses (or as otherwise expressly provided in this Lease), to be responsible, as provided in the immediately preceding paragraph, for capital repairs and replacements required to be made to the Project. If Tenant fails to maintain any portion of
the Premises for which Tenant is responsible as part of the Tenant Maintenance Obligations in a manner reasonably acceptable to Landlord within the requirements of this Lease, Landlord shall have the right, but not the obligation, to provide Tenant
with written notice thereof and to assume the Tenant Maintenance Obligations if Tenant does not cure Tenant’s failure within 15 days after receipt of such notice. 

14. Tenant’s Repairs. Subject to Section 13 hereof, Tenant, at its expense, shall repair, replace and maintain in good
condition all portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows, interior walls, and the interior side of demising walls. Such repair and replacement may include capital expenditures and repairs
whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give Tenant notice of such failure. If Tenant fails to commence cure of such failure within 10 days
of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant within 10 days after demand therefor; provided, however, that if such failure by Tenant creates
or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure from Tenant. Subject to Sections 17 and 18, Tenant shall bear the full uninsured cost of
any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the Premises. 

15. Mechanic’s Liens. Tenant shall discharge, by bond or otherwise, any mechanic’s lien filed against the Premises or against
the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant within 10 days after Tenant receives notice of the filing thereof, at Tenant’s sole cost and shall otherwise keep the Premises and the
Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have the right, but not the obligation, to pay such claim or
post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant shall lease or finance the acquisition of office
equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business at the Premises, Tenant warrants that in connection with any Uniform Commercial Code Financing Statement filed as
a matter of public record by any lessor or creditor of Tenant, Tenant shall use reasonable good faith efforts to cause such lessor or creditor to cause such Financing Statement upon its face or by exhibit thereto to indicate that such Financing

  
 17 

 
Statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the address of the Project be furnished on the statement without qualifying
language as to applicability of the lien only to removable personal property, located In an identified suite held by Tenant. Notwithstanding the foregoing, Tenant shall have the right to contest, in good faith, any mechanics’ lien claims. 

16. Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord, its officers, directors, employees,
managers, agents, sub-agents, constituent entities and lease signators (collectively, “Landlord Indemnified Parties”) harmless from and against any and all Claims for injury or death to persons or damage to property occurring within
or about the Premises or the Project arising directly or indirectly out of (a) use or occupancy of the Premises or the Project during the Term or any holding over (including, without limitation, any act, omission or neglect by Tenant or any
Tenant’s Parties in or about the Premises or at the Project), or (b) the a breach or default by Tenant in the performance of any of its obligations hereunder, except to the extent caused by the willful misconduct or gross negligence of
Landlord Indemnified Parties. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without limitation, loss of records kept within the Premises). Tenant further waives any and all Claims
for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of records). Landlord Indemnified Parties shall not be liable for any damages arising
from any act, omission or neglect of any tenant in the Project or of any other third party or Tenant Parties. 
 Notwithstanding any
contrary provision of this Lease, Tenant shall not be liable to Landlord for any consequential damages, arising from a default by Tenant under this Lease; provided that this sentence shall not apply to Landlord’s damages (x) as expressly
provided for in Section 8. and/or (y) in connection with Tenant’s obligations as more fully set forth in Section 30. In no event shall the foregoing limit the damages to which Landlord is entitled under
Section 21. 
 17. Insurance. Landlord shall maintain all risk property and, if applicable, sprinkler damage insurance
covering the full replacement cost of the Project. Landlord shall further procure and maintain commercial general liability insurance with a single loss limit of not less than $2,000,000 for bodily injury and property damage with respect to the
Project. Landlord may, but is not obligated to, maintain such other insurance and additional coverages as it may deem necessary, including, but not limited to, flood, environmental hazard and earthquake, loss or failure of building equipment, errors
and omissions, rental loss during the period of repair or rebuilding, workers’ compensation insurance and fidelity bonds for employees employed to perform services and insurance for any improvements installed by Tenant or which are in addition
to the standard improvements customarily furnished by Landlord without regard to whether or not such are made a part of the Project. All such insurance shall be included as part of the Operating Expenses. The Project may be included in a blanket
policy (in which case the cost of such insurance allocable to the Project will be determined by Landlord based upon the insurer’s cost calculations). Tenant shall also reimburse Landlord for any increased premiums or additional insurance which
Landlord reasonably deems necessary as a result of Tenant’s use of the Premises. 
 Tenant, at its sole cost and expense, shall
maintain during the Term: all risk property insurance with business interruption and extra expense coverage, covering the full replacement cost of all property and improvements installed or placed in the Premises by Tenant at Tenant’s expense;
workers’ compensation insurance with no less than the minimum limits required by law; employer’s 

  
 18 

 
liability insurance with employers liability limits of $1,000,000 bodily injury by accident - each accident, $1,000,000 bodily injury by disease - policy limit, and $1,000,000 bodily injury by
disease - each employee; and commercial general liability insurance, with a minimum limit of not less than $2,000,000 per occurrence for bodily injury and property damage with respect to the Premises. The commercial general liability insurance
maintained by Tenant shall name Alexandria Real Estate Equities, Inc., and Landlord, Its officers, directors, employees, managers, agents, sub-agents, constituent entities and lease signators (collectively, “Landlord Insured
Parties”), as additional insureds; insure on an occurrence and not a claims-made basis (provided that Tenant’s products liability insurance may be on a claims-made basis); be issued by insurance companies which have a rating of not
less than policyholder rating of A and financial category rating of at least Class X in “Best’s Insurance Guide”; shall not be cancelable for nonpayment of premium unless 30 days prior written notice shall have been given to Landlord
from the insurer; not contain a hostile fire exclusion; contain a contractual liability endorsement; and provide primary coverage to Landlord Insured Parties (any policy issued to Landlord Insured Parties providing duplicate or similar coverage
shall be deemed excess over Tenant’s policies, regardless of limits). Certificates of insurance showing the limits of coverage required hereunder and showing Landlord as an additional insured shall be delivered to Landlord by Tenant prior to
(i) the earlier to occur of (x) the Commencement Date, or (y) the date that Tenant accesses the Premises under this Lease, and (ii) each renewal of said insurance. Tenant’s policy may be a “blanket policy” with an
aggregate per location endorsement which specifically provides that the amount of insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least 5 days prior to the expiration of such policies, furnish Landlord with
renewal certificates. 
 In each instance where insurance is to name Landlord as an additional insured, Tenant shall upon written request of
Landlord also designate and furnish certificates so evidencing Landlord as additional insured to; (i) any lender of Landlord holding a security interest in the Project or any portion thereof, (ii) the landlord under any lease wherein
Landlord is tenant of the real property on which the Project is located, if the interest of Landlord is or shall become that of a tenant under a ground or other underlying lease rather than that of a fee owner, and/or (iii) any management
company retained by Landlord to manage the Project. 
 The property insurance obtained by Landlord and Tenant shall include a waiver of
subrogation by the insurers and all rights based upon an assignment from its insured, against Landlord or Tenant, and their respective officers, directors, employees, managers, agents, invitees and contractors (“Related Parties”),
in connection with any loss or damage thereby insured against. Neither party nor its respective Related Parties shall be liable to the other for loss or damage caused by any risk insured against under property insurance required to be maintained
hereunder, and each party waives any claims against the other party, and its respective Related Parties’,, for such loss or damage. The failure of a party to insure its property shall not void this waiver. Landlord and its respective Related
Parties shall not be liable for, and Tenant hereby waives all claims against such parties for, business interruption and losses occasioned thereby sustained by Tenant or any person claiming through Tenant resulting from any accident or occurrence in
or upon the Premises or the Project from any cause whatsoever. If the foregoing waivers shall contravene any law with respect to exculpatory agreements, the liability of Landlord or Tenant shall be deemed not released but shall be secondary to the
other’s insurer. 

  
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 Landlord may require insurance policy limits to be raised to conform with requirements of
Landlord’s lender and/or to bring coverage limits to levels then being generally required of new tenants within the Project; provided, however, that the increased amount of coverage is consistent with coverage amounts then commonly being
required by institutional owners of similar projects with tenants occupying similar size premises in the geographical area In which the Project is located. 

18. Restoration. If, at any time during the Term, the Project or the Premises are damaged or destroyed by a fire or other insured
casualty, Landlord shall notify Tenant within 60 days after discovery of such damage as to the amount of time Landlord reasonably estimates it will take to restore the Project or the Premises, as applicable (the “Restoration
Period”). If the Restoration Period is estimated to exceed 12 months (the “Maximum Restoration Period”), Landlord may, in such notice, elect to terminate this Lease as of the date that is 75 days after the date of discovery
of such damage or destruction; provided, however, that notwithstanding Landlord’s election to restore, Tenant may elect to terminate this Lease by written notice to Landlord delivered within 5 business days of receipt of a notice from
Landlord estimating a Restoration Period for the Premises longer than the Maximum Restoration Period. Unless either Landlord or Tenant so elects to terminate this Lease, Landlord shall, subject to receipt of sufficient insurance proceeds (with any
deductible to be treated as a current Operating Expense), promptly restore the Premises (excluding the improvements installed by Tenant or by Landlord and paid for by Tenant), subject to delays arising from the collection of insurance proceeds, from
Force Majeure events or as needed to obtain any license, clearance or other authorization of any kind required to enter into and restore the Premises issued by any Governmental Authority having jurisdiction over the use, storage, handling,
treatment, generation, release, disposal, removal or remediation of Hazardous Materials (as defined in Section 30) in, on or about the Premises (collectively referred to herein as “Hazardous Materials Clearances”);
provided, however, that if repair or restoration of the Premises is not substantially complete as of the end of the Maximum Restoration Period or, if longer, the Restoration Period, Landlord may, in its sole and absolute
discretion, elect not to proceed with such repair and restoration, or Tenant may by written notice to Landlord delivered within 10 business days of the expiration of the Maximum Restoration Period or, if longer, the Restoration Period, elect to
terminate this Lease, in which event Landlord shall be relieved of its obligation to make such repairs or restoration and this Lease shall terminate as of the date that is 75 days after the later of: (i) discovery of such damage or destruction,
or (ii) the date all required Hazardous Materials Clearances are obtained, but Landlord shall retain any Rent paid and the right to any Rent payable by Tenant prior to such election by Landlord or Tenant. 

After the repairs and/or restoration required to be done by Landlord to the Premises have been completed, Tenant, at its expense, shall
promptly perform, subject to delays arising from the collection of insurance proceeds, from Force Majeure (as defined in Section 34) events or to obtain Hazardous Material Clearances, all repairs or restoration of Tenant’s property
necessary for the conduct of Tenant’s business at the Premises and any improvements or Alterations to the Premises installed by Tenant and shall promptly re-enter the Premises and commence doing business in accordance with this Lease.
Notwithstanding the foregoing, either Landlord or Tenant may terminate this Lease upon written notice to the other if the Premises are damaged during the last year of the Term and Landlord reasonably estimates that it will take more than 2 months to
repair such damage; provided, however, that such notice is delivered within 10 business days after the date that Landlord provides Tenant with written notice of the estimated Restoration Period. Notwithstanding anything to the contrary contained
herein, Landlord shall also have the right to terminate this Lease if insurance proceeds are not available for such restoration. Tenant shall have the right to terminate this Lease if insurance proceeds are not available for such restoration and
Landlord does not otherwise elect to proceed with the restoration. Rent shall be abated from the date all required Hazardous Material Clearances are obtained until the Premises are repaired and restored, in the proportion which the area

  
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of the Premises, if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant with other space during the period of repair that is suitable for
the temporary conduct of Tenant’s business. In the event that no Hazardous Material Clearances are required to be obtained by Tenant with respect to the Premises, rent abatement shall commence on the date of discovery of the damage or
destruction. Such abatement shall be the sole remedy of Tenant, and except as provided in this Section 18, Tenant waives any right to terminate the Lease by reason of damage or casualty loss. 

The provisions of this Lease, including this Section 18. constitute an express agreement between Landlord and Tenant with respect
to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any damage or
destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section 18 sets forth their entire understanding and agreement with respect to such matters. 

19. Condemnation. If the whole or any material part of the Premises or the Project is taken for any public or quasi-public use
under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a “Taking” or “Taken”), and the Taking would in Landlord’s reasonable judgment,
materially interfere with or impair Landlord’s ownership or operation of the Project or would in the reasonable judgment of Landlord and Tenant either prevent or materially interfere with Tenant’s use of the Premises or the parking spaces
allocated to Tenant pursuant to Section 10 (as resolved, if the parties are unable to agree, by arbitration by a single arbitrator with the qualifications and experience appropriate to resolve the matter and appointed pursuant to and
acting in accordance with the rules of the American Arbitration Association), then upon written notice by Landlord or Tenant to the other this Lease shall terminate and Rent shall be apportioned as of said date. If part of the Premises or the
parking spaces allocated to Tenant pursuant to Section 10 shall be Taken, and this Lease is not terminated as provided above, Landlord shall promptly restore the Premises and the Project as nearly as is commercially reasonable under the
circumstances to their condition prior to such partial Taking and the rentable square footage of the Building, the rentable square footage of the Premises, Tenant’s Share of Operating Expenses and the Rent payable hereunder during the unexpired
Term shall be reduced to such extent as may be fair and reasonable under the circumstances. Upon any such Taking, Landlord shall be entitled to receive the entire price or award from any such Taking without any payment to Tenant, and Tenant hereby
assigns to Landlord Tenant’s interest, if any, in such award. Tenant shall have the right, to the extent that same shall not diminish Landlord’s award, to make a separate claim against the condemning authority (but not Landlord) for such
compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures, if a separate award for such items is made to Tenant. Tenant hereby waives any and all rights it might otherwise have
pursuant to any provision of state law to terminate this Lease upon a partial Taking of the Premises or the Project. 
 20. Events of
Default. Each of the following events shall be a default (“Default”) by Tenant under this Lease: 
 (a)
Payment Defaults. Tenant shall fall to pay any installment of Rent or any other payment hereunder when due; provided, however, that Landlord will give Tenant notice and an opportunity to cure any failure to pay Rent (prior to such
failure constituting a Default under the Lease) within 5 days of any such notice not more than once in any 12 month period and Tenant agrees that such notice shall be in lieu of and not in addition to, or shall be deemed to be, any notice required
by law. 

  
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 (b) Insurance. Any insurance required to be maintained by Tenant pursuant to this
Lease shall be canceled or terminated or shall expire or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance at least 10 days before the
expiration of the current coverage. 
 (c) Abandonment. Tenant shall abandon the Premises. Tenant shall not be deemed to have
abandoned the Premises if Tenant provides Landlord with reasonable advance notice prior to vacating and, at the time of vacating the Premises, (i) Tenant completes Tenant’s obligations under the Surrender Plan in compliance with
Section 28. (ii) Tenant has obtained the release of the Premises of all Hazardous Materials Clearances and the Premises are free from any residual impact from the Tenant HazMat Operations and provides reasonably detailed
documentation to Landlord confirming such matters, (iii) Tenant has made reasonable arrangements with Landlord for the security of the Premises for the balance of the Term, and (iv) Tenant continues during the balance of the Term to
satisfy and perform all of Tenant’s obligations under this Lease as they come due. 
 (d) Improper Transfer. Tenant shall
assign, sublease or otherwise transfer or attempt to transfer all or any portion of Tenant’s interest in this Lease or the Premises except as expressly permitted herein, or Tenant’s Interest in this Lease shall be attached, executed upon,
or otherwise judicially seized and such action is not released within 90 days of the action. 
 (e) Liens. Tenant shall fail
to discharge or otherwise obtain the release of any lien placed upon the Premises in violation of this Lease within 10 days after Tenant receives notice of any such lien is filed against the Premises. 

(f) Insolvency Events. Tenant or any guarantor or surety of Tenant’s obligations hereunder shall: (A) make a general
assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or seeking reorganization,
arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or of any substantial part of its property (collectively a
“Proceeding for Relief); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor, or surety is an
individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

(g) Estoppel Certificate or Subordination Agreement. Tenant fails to execute any document required from Tenant under Sections
23 or 27 within 5 business days after a second notice requesting such document. 
 (h) Other Defaults. Tenant shall fail
to comply with any provision of this Lease other than those specifically referred to in this Section 20. and, except as otherwise expressly provided herein, such failure shall continue for a period of 30 days after written notice thereof
from Landlord to Tenant. 

  
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 Any notice given under Section 20(h) hereof shall: (i) specify the alleged
default, (ii) demand that Tenant cure such default, (iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination
of this Lease unless Landlord elects otherwise in such notice; provided that if the nature of Tenant’s default pursuant to Section 20(h) is such that it cannot be cured by the payment of money and reasonably requires more
than 30 days to cure, then Tenant shall not be deemed to be in default if Tenant commences such cure within said 30 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be
completed no later than 60 days from the date of Landlord’s notice. 
 21. Landlord’s Remedies. 

(a) Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation of
Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to 12% per annum or the highest rate
permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing herein shall be construed to create or impose a duty on Landlord to mitigate any damages resulting from
Tenant’s Default hereunder. 
 (b) Late Payment Rent. Late payment by Tenant to Landlord of Rent and other sums due will cause
Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges and late charges which may be
imposed on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to Landlord an additional sum equal to
6% of the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due
shall bear interest at the Default Rate from the 5th day after the date due until paid. 
 (c) Remedies. Upon the occurrence of a
Default, Landlord, at its option, without further notice or demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each
and all of which shall be cumulative and nonexclusive, without any notice or demand whatsoever. 
 (i) Terminate this Lease, or at
Landlord’s option, Tenant’s right to possession only, in which event Tenant shall immediately surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may have for
possession or arrearages in rent, enter upon and take possession of the Premises and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof, without being liable for prosecution or any claim or damages
therefor; 
 (ii) Upon any termination of this Lease, whether pursuant to the foregoing Section 21(c)(i) or otherwise, Landlord
may recover from Tenant the following: 
 (A) The worth at the time of award of any unpaid rent which has been earned at the
time of such termination; plus 

  
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 (B) The worth at the time of award of the amount by which the unpaid rent which
would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(C) The worth at the time of award of the amount by which the unpaid rent for the balance of the Term after the time of award
exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
 (D) Any other amount
necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, specifically including, but
not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or any portion thereof for a new tenant, whether for the same or a different use, and any special concessions made to obtain a new tenant;
and 
 (E) At Landlord’s election, such other amounts in addition to or in lieu of the foregoing as may be permitted
from time to time by applicable law. 
 The term “rent” as used in this Section 21 shall be deemed to be and to
mean all sums of every nature required to be paid by Tenant pursuant to the terms of this Lease, whether to Landlord or to others. As used in Sections 21(c)(ii)(A) and (B), above, the “worth at the time of award” shall be
computed by allowing interest at the Default Rate. As used in Section 21(c)(ii)(C) above, the “worth at the time of award” shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of
San Francisco at the time of award plus 1%. 
 (iii) Landlord may continue this Lease in effect after Tenant’s Default and recover
rent as it becomes due (Landlord and Tenant hereby agreeing that Tenant has the right to sublet or assign hereunder, subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this Lease following a Default by
Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies hereunder, including the right to recover all Rent as it becomes due. 

(iv) Whether or not Landlord elects to terminate this Lease following a Default by Tenant, Landlord shall have the right to terminate any and
all subleases, licenses, concessions or other consensual arrangements for possession entered into by Tenant and affecting the Premises or may, in Landlord’s sole discretion, succeed to Tenant’s interest in such subleases, licenses,
concessions or arrangements. Upon Landlord’s election to succeed to Tenant’s interest in any such subleases, licenses, concessions or arrangements, Tenant shall, as of the date of notice by Landlord of such election, have no further right
to or interest in the rent or other consideration receivable thereunder. 
 (v) Independent of the exercise of any other remedy of Landlord
hereunder or under applicable law, Landlord may conduct an environmental test of the Premises as generally described in Section 30(d) hereof, at Tenant’s expense, provided that Tenant shall not be required to pay for such tests more
than once in any 12 month period, unless contamination has occurred for which Tenant is responsible under this Section 30. 

  
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 (d) Effect of Exercise. Exercise by Landlord of any remedies hereunder or otherwise
available shall not be deemed to be an acceptance of surrender of the Premises and/or a termination of this Lease by Landlord, it being understood that such surrender and/or termination can be effected only by the express written agreement of
Landlord and Tenant. Any law, usage, or custom to the contrary notwithstanding, Landlord shall have the right at all times to enforce the provisions of this Lease in strict accordance with the terms hereof; and the failure of Landlord at any time to
enforce its rights under this Lease strictly in accordance with same shall not be construed as having created a custom in any way or manner contrary to the specific terms, provisions, and covenants of this Lease or as having modified the same and
shall not be deemed a waiver of Landlord’s right to enforce one or more of its rights in connection with any subsequent default. A receipt by Landlord of Rent or other payment with knowledge of the breach of any covenant hereof shall not be
deemed a waiver of such breach, and no waiver by Landlord of any provision of this Lease shall be deemed to have been made unless expressed in writing and signed by Landlord. To the greatest extent permitted by law, Tenant waives the service of
notice of Landlord’s intention to re-enter, re-take or otherwise obtain possession of the Premises as provided in any statute, or to institute legal proceedings to that end, and also waives all right of redemption in case Tenant shall be
dispossessed by a judgment or by warrant of any court or judge. Any reletting of the Premises or any portion thereof shall be on such terms and conditions as Landlord in its sole discretion may determine. Landlord shall not be liable for, nor shall
Tenant’s obligations hereunder be diminished because of, Landlord’s failure to relet the Premises or collect rent due in respect of such reletting or otherwise to mitigate any damages arising by reason of Tenant’s Default. 

22. Assignment and Subletting. 

(a) General Prohibition. Without Landlord’s prior written consent subject to and on the conditions described in this
Section 22, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its leasehold interest or grant any concession
or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. If Tenant is a corporation, partnership or limited liability company, the shares or other ownership interests thereof which are not actively
traded upon a stock exchange or in the over-the-counter market, a transfer or series of transfers whereby 50% or more of the issued and outstanding shares or other ownership interests of such corporation are, or voting control is, transferred (but
excepting transfers upon deaths of individual owners) from a person or persons or entity or entities which were owners thereof at time of execution of this Lease to persons or entities who were not owners of shares or other ownership interests of
the corporation, partnership or limited liability company at time of execution of this Lease, shall be deemed an assignment of this Lease requiring the consent of Landlord as provided in this Section 22. 

(b) Permitted Transfers. If Tenant desires to assign, sublease, hypothecate or otherwise transfer this Lease or sublet the Premises,
other than pursuant to a Permitted Assignment (as defined below), then at least 10 business days, but not more than 60 business days, before the date Tenant desires the assignment or sublease to be effective (the “Assignment Date”),
Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the proposed use of the Premises and any Hazardous Materials proposed to be used, stored
handled, treated, generated in or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all material terms and conditions of the proposed assignment or sublease,
including a copy of any proposed assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration whether to 

  
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grant its consent. Landlord may, by giving written notice to Tenant within 10 business days after receipt of the Assignment Notice: (i) grant such consent (provided that Landlord shall
further have the right to review and approve or disapprove, in its reasonable discretion, the proposed form of sublease prior to the effective date of any such subletting), (ii) refuse such consent, in its reasonable discretion; or
(iii) terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment Date (an “Assignment Termination”). Among other reasons, it shall be reasonable for Landlord to withhold its consent
in any of these Instances: (1) the proposed assignee or subtenant is a governmental agency; (2) in Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant would entail any alterations that would
materially lessen the value of the leasehold improvements in the Premises, or would require increased services by Landlord; (3) in Landlord’s reasonable judgment, the proposed assignee or subtenant is engaged in areas of scientific
research or other business concerns at the Premises that are controversial such that they may (i) attract or cause negative publicity for or about the Building or the Project, (ii) negatively affect the reputation of the Building, the
Project or Landlord, (iii) attract protestors to the Building or the Project, or (iv) lessen the attractiveness of the Building or the Project to any tenants or prospective tenants, purchasers or lenders; (4) in Landlord’s
reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment or sublease; (5) in Landlord’s reasonable judgment, the character,
reputation, or business of the proposed assignee or subtenant is inconsistent with the desired tenant-mix or the quality of other tenancies in the Project or is inconsistent with the type and quality of the nature of the Building; (6) Landlord
has received from any prior landlord to the proposed assignee or subtenant a negative report concerning such prior landlord’s experience with the proposed assignee or subtenant’s failure to comply with its lease obligations;
(7) Landlord has experienced previous defaults by or is in litigation with the proposed assignee or subtenant; (8) the use of the Premises by the proposed assignee or subtenant will violate any applicable Legal Requirement; (9) the
proposed assignee or subtenant, or any entity that, directly or indirectly, controls, is controlled by, or is under common control with the proposed assignee or subtenant, is then an occupant of the Project; (10) the proposed assignee or
subtenant is an entity with whom Landlord is negotiating to lease space in the Project; or (11) the assignment or sublease is prohibited by Landlord’s lender. Landlord shall use reasonable efforts to respond to each Assignment Notice
within 10 business days after Landlord’s receipt of such Assignment Notice along with all documentation required to be delivered hereunder. If Landlord fails to respond within such 10 business day period, then Tenant shall provide Landlord with
a second written notice stating in bold and all caps 12 point font or larger that Landlord’s failure to respond to Tenant’s Assignment Notice within 3 business days after Landlord’s receipt of the second notice shall be deemed
approval by Landlord, and if Landlord does not respond within such 3 business day period, then Landlord shall be deemed to have approved such Assignment. If Landlord delivers notice of its election to exercise an Assignment Termination, Tenant shall
have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 business days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such Assignment Notice, this
Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space described in such Assignment
Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed assignment, sublease or other
transfer. Tenant shall pay to Landlord a fee equal to Two Thousand Five Hundred Dollars ($2,500) in connection with its consideration of any Assignment Notice and/or its preparation or review of any consent documents. Notwithstanding the foregoing,
Landlord’s consent to an assignment of this Lease or a subletting of any portion 

  
 26 

 
of the Premises to any entity controlling, controlled by or under common control with Tenant (a “Control Permitted Assignment”) shall not be required, provided that Landlord
shall have the right to reasonably approve the form of any such sublease or assignment. In addition, Tenant shall have the right to assign this Lease, upon 30 days prior written notice to Landlord but without obtaining Landlord’s prior written
consent, to a corporation or other entity which is a successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant
provided that (i) such merger or consolidation, or such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in
accordance with generally accepted accounting principles (“GAAP”)) of the assignee is not less than the greater of the net worth (as determined in accordance with GAAP) of Tenant as of (A) the Commencement Date, or (B) as
of the date of Tenant’s most current quarterly or annual financial statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease (a “Corporate Permitted
Assignment”). Control Permitted Assignments and Corporate Permitted Assignments are hereinafter referred to as “Permitted Assignments.” 

(c) Additional Conditions. As a condition to any such assignment or subletting, whether or not Landlord’s consent is required,
Landlord may require: 
 (i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting, that if
Landlord gives such party notice that Tenant is in Default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to credit
such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall Landlord or
its successors or assigns be obligated to accept such attornment; and 
 (ii) A list of Hazardous Materials, certified by the proposed
assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents relating to such use, storage,
handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without limitation: permits; approvals;
reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has given its
written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks
installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s) of the such documents containing information of a
proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 
 (d) No
Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant and any guarantor or surety of Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for
the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the Rent due and payable by a sublessee 

  
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or assignee (or a combination of the rental payable under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceeds the sum of the rental
payable under this Lease, (excluding however, any Rent payable under this Section) and actual and reasonable brokerage fees, legal costs, any design or construction fees or other reasonable and customary concessions directly related to and required
pursuant to the terms of any such sublease) (“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant
shall sublet the Premises or any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as
attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have
the right to collect such rent. 
 (e) No Waiver. The consent by Landlord to an assignment or subletting shall not relieve Tenant or
any assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and primary liability under the
Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of this Lease or a consent to
any subletting, assignment or other transfer of the Premises. 
 (f) Prior Conduct of Proposed Transferee. Notwithstanding any other
provision of this Section 22, other than in connection with a Permitted Assignment, if (i) the proposed assignee or sublessee of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial
action in connection with Hazardous Materials contaminating a property, where the contamination resulted from such party’s action or use of the property in question, (ii) the proposed assignee or sublessee is subject to an enforcement
order issued by any Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting
to any Governmental Authority), or (iii) because of the existence of a pre-existing environmental condition in the vicinity of or underlying the Project, the risk that Landlord would be targeted as a responsible party in connection with the
remediation of such pre-existing environmental condition would be materially increased or exacerbated by the proposed use of Hazardous Materials by such proposed assignee or sublessee, Landlord shall have the absolute right to refuse to consent to
any assignment or subletting to any such party. 
 23. Estoppel Certificate. Tenant shall, within 10 business days of written notice
from Landlord, execute, acknowledge and deliver a statement in writing in any form reasonably requested by a proposed lender or purchaser, (i) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the
nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which the rental and other charges are paid in advance, if any, (ii) acknowledging that there are not any uncured defaults
on the part of Landlord hereunder, or specifying such defaults if any are claimed, and (iii) setting forth such further information with respect to the status of this Lease or the Premises as may be requested thereon. Any such statement may be
relied upon by any prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure to deliver such statement within five (5) business days following Landlord’s second
request therefor shall, at the option of Landlord, constitute a Default under this Lease, and, in any event, shall be conclusive upon Tenant that the Lease is in full 

  
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force and effect and without modification except as may be represented by Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. 

Upon request by Tenant, Landlord will similarly execute an estoppel certificate: (i) certifying that this Lease is unmodified and in full
force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full force and effect) and the dates to which the rental and other charges are paid in advanced, if any,
(ii) acknowledging that there are not, to Landlord’s knowledge, any uncured defaults on the part of Tenant hereunder, or specifying such defaults if any are claimed and (iii) setting forth such further information with respect to the
status of this Lease or the Premises as may be reasonably requested thereon. 
 24. Quiet Enjoyment. So long as Tenant is not in
Default under this Lease, Tenant shall, subject to the terms of this Lease, at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 

25. Prorations. All prorations required or permitted to be made hereunder shall be made on the basis of a 360 day year and 30 day
months. 
 26. Rules and Regulations. Tenant shall, at all times during the Term and any extension thereof, comply with all
reasonable non-discriminatory rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as Exhibit E. If there is any
conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Landlord shall not have any liability or obligation for the breach of any rules or regulations by other tenants In
the Project and shall not enforce such rules and regulations in a discriminatory manner. 
 27. Subordination. This Lease and
Tenant’s interest and rights hereunder are hereby made and shall be subject and subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements,
renewals, modifications, consolidations, refinancing, assignments and extensions thereof, without the necessity of any further instrument or act on the part of Tenant; provided, however that so long as there is no Default hereunder,
Tenant’s right to possession of the Premises shall not be disturbed by the Holder of any such Mortgage. Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to any such Holder. Tenant agrees upon demand to execute,
acknowledge and deliver such instruments, confirming such subordination, and such instruments of attornment as shall be requested by any such Holder, provided any such instruments contain appropriate non-disturbance provisions assuring Tenant’s
quiet enjoyment of the Premises as set forth in Section 24 hereof. Notwithstanding the foregoing, any such Holder may at any time subordinate its Mortgage to this Lease, without Tenant’s consent, by notice in writing to Tenant, and
thereupon this Lease shall be deemed prior to such Mortgage without regard to their respective dates of execution, delivery or recording and in that event such Holder shall have the same rights with respect to this Lease as though this Lease had
been executed prior to the execution, delivery and recording of such Mortgage and had been assigned to such Holder. The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of trust, security assignments and
any other encumbrances, and any reference to the “Holder” of a Mortgage shall be deemed to include the beneficiary under a deed of trust. As of the date of this Lease, there is no existing Mortgage encumbering the Project. 

  
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 Upon request of Tenant, Landlord shall deliver to Tenant an agreement (“SNDA”)
from any future Holder of a Mortgage on the Project, if any, that such Holder will recognize and not disturb Tenant’s right of possession pursuant to this Lease provided that Tenant is not in Default under this Lease. The SNDA shall be on the
form proscribed by the Holder and Tenant shall pay the Holder’s fees and costs in connection with obtaining such SNDA; provided, however, that Landlord shall request that Holder make any changes to the SNDA requested by Tenant. Landlord’s
failure to cause the Holder to enter into the SNDA with Tenant (or make any of the changes requested by Tenant) shall not be a default by Landlord under this Lease. 

28. Surrender. Upon the expiration of the Term or earlier termination of Tenant’s right of possession, Tenant shall surrender the
Premises to Landlord in the same condition as received, subject to any Alterations or Installations permitted by Landlord to remain in the Premises, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or
released or disposed of from, the Premises by any person other than a Landlord Party (collectively, “Tenant HazMat Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty
loss and condemnation covered by Sections 18 and 19 excepted. At least 3 months prior to the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any Governmental
Authority) to be taken by Tenant in order to surrender the Premises (including any Installations permitted by Landlord to remain in the Premises) at the expiration or earlier termination of the Term, free from any residual impact from the Tenant
HazMat Operations and otherwise released for unrestricted use and occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a current listing of (i) all Hazardous Materials licenses and permits held by or on
behalf of any Tenant Party with respect to the Premises, and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the Premises, and shall be subject to the review and approval of Landlord’s
environmental consultant. In connection with the review and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat
Operations as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at
Tenant’s expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective
date of such surrender or early termination of the Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional Rent, for the actual out-of pocket expense incurred by Landlord for Landlord’s
environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify satisfactory completion of the same, which cost shall not exceed $2,500. Landlord shall have the unrestricted right to deliver such Surrender Plan
and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. 
 If Tenant
shall fail to prepare or submit a Surrender Plan approved by Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual
effect of Tenant HazMat Operations in, on or about the Premises, Landlord shall have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual
impact from Tenant HazMat Operations, the cost of which actions shall be reimbursed by Tenant as Additional Rent, without regard to the limitation set forth in the first paragraph of this Section 28. 

  
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 Tenant shall immediately return to Landlord all keys and/or access cards to parking, the Project,
restrooms or all or any portion of the Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of replacing such lost access card or
key or the cost of reprogramming the access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so removed by Tenant as permitted or
required herein shall be deemed abandoned and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from Landlord’s retention and/or disposition of
such property. All obligations of Tenant or Landlord hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Section 30 hereof, shall survive the expiration or earlier termination of the
Term, including, without limitation, indemnity obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 

29. Waiver of Jury Trial. TO THE EXTENT PERMITTED BY LAW, TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A JURY
PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE
TRANSACTIONS RELATED HERETO. 
 30. Environmental Requirements. 

(a) Prohibition/Compliance/lndemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be brought
upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises or the Project in violation of applicable Environmental Requirements (as hereinafter defined) by Tenant or any Tenant Party. If Tenant
breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises during the Term or any holding over results In contamination of the Premises, the Project or any adjacent property or if
contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises by anyone other than Landlord and
Landlord’s employees, agents and contractors otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and contractors harmless from any and
all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages (including, without limitation,
punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without limitation, attorneys’,
consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether or not based upon personal
injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise during or after the Term as a
result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal, or restoration work required
by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials on the

  
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Premises, the Building, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Building, the Project or any
adjacent property, Tenant shall promptly take all actions at its sole expense and in accordance with applicable Environmental Requirements as are necessary to return the Premises, the Building, the Project or any adjacent property to the condition
existing prior to the time of such contamination, provided that Landlord’s approval of such action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material
adverse long-term or short-term effect on the Premises, the Building or the Project. Notwithstanding anything to the contrary contained in Section 28 and/or this Section 30. Tenant shall not be responsible for, and the
indemnification and hold harmless obligation set forth in this paragraph shall not apply to (i) contamination in the Premises or the Project which Tenant can prove to Landlord’s reasonable satisfaction existed in the Premises or the
Project immediately prior to the date of this Lease, or (ii) the presence of any Hazardous Materials in the Premises or the Project which Tenant can prove to Landlord’s reasonable satisfaction migrated from outside of the Premises into the
Premises or outside the Project into the Project, except to the extent in either case, the presence of such Hazardous Materials (x) is the result of a breach by Tenant of any of its obligations under this Lease, or (y) was caused,
contributed to or exacerbated by Tenant or any Tenant Party. 
 (b) Business. Landlord acknowledges that it is not the intent of this
Section 30 to prohibit Tenant from using the Premises for the Permitted Use. Tenant may operate its business according to prudent industry practices so long as the use or presence of Hazardous Materials is strictly and properly monitored
according to all then applicable Environmental Requirements. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to the Commencement Date a list
identifying each type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on, or released or disposed of from, the Premises and setting forth any and all governmental approvals or permits required in connection
with the presence, use, storage, handling, treatment, generation, release or disposal of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Upon Landlord’s request, or any time that Tenant is
required to deliver a Hazardous Materials List to any Governmental Authority (e.g., the fire department) in connection with Tenant’s use or occupancy of the Premises, Tenant shall deliver to Landlord a copy of such Hazardous Materials List.
Tenant shall deliver to Landlord true and correct copies of the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to the
Commencement Date, or if unavailable at that time, concurrent with the receipt from or submission to a Governmental Authority: permits; approvals; reports; storage and management plans, notice of violations of any Legal Requirements; plans relating
to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has given Tenant its written consent to do so, which consent may be withheld in
Landlord’s sole and absolute discretion); all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks Installed in, on or under the Project for the closure of any such
tanks; and a Surrender Plan (to the extent surrender in accordance with Section 28 cannot be accomplished in 3 months). Tenant is not required, however, to provide Landlord with any portion(s) of the Haz Mat Documents containing
information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. It is not the intent of this Section to provide Landlord with information which could be detrimental to
Tenant’s business should such information become possessed by Tenant’s competitors. 

  
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 (c) Tenant Representation and Warranty. Tenant hereby represents and warrants to Landlord
that (i) neither Tenant nor any of its legal predecessors has been required by any prior landlord, lender or Governmental Authority at any time to take remedial action in connection with Hazardous Materials contaminating a property which
contamination was permitted by Tenant of such predecessor or resulted from Tenant’s or such predecessor’s action or use of the property in question, and (ii) Tenant is not subject to any enforcement order issued by any Governmental
Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental Authority).
If this representation and warranty is not true as of the date of this lease, Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion. 

(d) Testing. Landlord shall have the right to conduct annual tests of the Premises to determine whether any contamination of the
Premises or the Project has occurred as a result of Tenant’s use. Tenant shall be required to pay the cost of such annual test of the Premises if there is violation of this Section 30 or if contamination for which Tenant is
responsible under this Section 30 is identified; provided, however, that if Tenant conducts its own tests of the Premises using third party contractors and test procedures acceptable to Landlord which tests are certified to Landlord,
Landlord shall accept such tests in lieu of the annual tests to be paid for by Tenant. In addition, at any time, and from time to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate
tests of the Premises and the Project to determine if contamination has occurred as a result of Tenant’s use of the Premises. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such
non-proprietary information concerning the use of Hazardous Materials in or about the Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section 30. Tenant shall pay all costs to
conduct such tests. If no such contamination is found, Landlord shall pay the costs of such tests (which shall not constitute an Operating Expense). Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of
the Premises made by or on behalf of Landlord during the Term without representation or warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental
conditions identified by such testing in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant. 

(e) Control Areas. Tenant shall be allowed to utilize up to its pro rata share of the Hazardous Materials inventory within any control
area or zone (located within the Premises), as designated by the applicable building code, for chemical use or storage. As used in the preceding sentence, Tenant’s pro rata share of any control areas or zones located within the Premises shall
be determined based on the rentable square footage that Tenant leases within the applicable control area or zone. For purposes of example only, if a control area or zone contains 10,000 rentable square feet and 2,000 rentable square feet of a
tenant’s premises are located within such control area or zone (while such premises as a whole contains 5,000 rentable square feet), the applicable tenant’s pro rata share of such control area would be 20%. 

(f) Underground Tanks. Tenant shall have no right to use or install any underground or other storage tanks at the Project. 

  
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 (g) Tenant’s Obligations. Tenant’s obligations under this Section 30
shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to complete the removal from the Premises of any Hazardous Materials
(including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises and the completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease
for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 
 (h)
Definitions. As used herein, the term “Environmental Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental
Authority regulating or relating to health, safety, or environmental conditions on, under, or about the Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation
and Liability Act; the Resource Conservation and Recovery Act; and all state and local counterparts thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and
includes any substance, material, waste, pollutant, or contaminant listed or defined as hazardous or toxic, or regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental Requirements,
asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied natural gas, or synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant
is and shall be deemed to be the “operator” of Tenant’s “facility” and the “owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products,
or residues generated, resulting, or produced therefrom. 
 31. Tenant’s Remedies/Limitation of Liability. Landlord shall not be
in default hereunder unless Landlord fails to perform any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will, due to the nature of the obligation, require a period of
time in excess of 30 days, then after such period of time as is reasonably necessary). Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage covering the Premises and to any landlord of
any lease of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by power of sale or a judicial action
if such should prove necessary to effect a cure; provided Landlord shall have furnished to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of Landlord hereunder shall be construed
as covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

All obligations of Landlord under this Lease will be binding upon Landlord only during the period of its ownership of the Premises and not
thereafter. The term “Landlord” in this Lease shall mean only the owner for the time being of the Premises. Upon the transfer by such owner of its interest in the Premises, such owner shall thereupon be released and discharged from
all obligations of Landlord thereafter accruing, but such obligations shall be binding during the Term upon each new owner for the duration of such owner’s ownership. 

32. Inspection and Access. Landlord and its agents, representatives, and contractors may enter the Premises at any reasonable time to
inspect the Premises and to make such repairs as may be required or permitted pursuant to this Lease and for any other business purpose. Landlord and Landlord’s representatives may enter the Premises during business hours on not less than 2
business days’ 

  
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advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for the purpose of effecting any such repairs,
inspecting the Premises, showing the Premises to prospective purchasers and, during the last 12 months of the Term, to prospective tenants or for any other business purpose. Landlord may erect a suitable sign on the Premises stating the Premises are
available to let or that the Project is available for sale. Landlord may grant easements, make public dedications, designate Common Areas and create restrictions on or about the Premises, provided that no such easement, dedication,
designation or restriction materially, adversely affects Tenant’s use or occupancy of the Premises for the Permitted Use or unreasonably increases Tenant’s obligations or liabilities under this Lease. At Landlord’s request, Tenant
shall execute such instruments as may be necessary for such easements, dedications or restrictions. Tenant shall at all times, except in the case of emergencies, have the right to escort Landlord or its agents, representatives, contractors or guests
while the same are in the Premises, provided such escort does not materially and adversely affect Landlord’s access rights hereunder. Landlord shall use reasonable efforts to comply with Tenant’s reasonable safety and confidentiality
requirements during any entry by Landlord into the Premises; provided, however, that Tenant has notified Landlord in writing of such safety and confidentiality requirements prior to Landlord’s entry into the Premises. 

Subject to the terms of this Section 32. Landlord may from time to time during the Term, during regular business hours and/or
otherwise at times mutually acceptable to Landlord and Tenant, conduct third party tours of the Premises (“Tours”), which Tours may be held with not less than 1 business day’s advance notice. Landlord shall endeavor to minimize
interference with Tenant’s operations in the Premises during such Tours. 
 33. Security. Tenant acknowledges and agrees that
security devices and services, if any, while intended to deter crime may not in given Instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises. Tenant agrees that Landlord
shall not be liable to Tenant for, and Tenant waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of
security with respect to the Premises. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the Premises and/or the
Project. Tenant shall at Tenant’s cost obtain insurance coverage to the extent Tenant desires protection against such criminal acts. 

34. Force Majeure. Except for the payment of Rent, neither Landlord nor Tenant shall be held responsible or liable for delays in the
performance of its obligations hereunder when caused by, related to, or arising out of acts of God, sinkholes or subsidence, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather, national, regional, or local disasters,
calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance, governmental restrictions, orders, limitations,
regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or other casualty, and other causes or events
beyond their reasonable control (“Force Majeure”). 
 35. Brokers. Landlord and Tenant each represents and warrants
that it has not dealt with any broker, agent or other similar person (collectively, “Broker”) in connection with this transaction and that no Broker brought about this transaction, other than Hughes Marino. Landlord and Tenant each
hereby agree to indemnify and hold the other harmless from and against any claims by any Broker, 

  
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other than Hughes Marino, claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 

36. Limitation on Landlord’s Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND
TENANT TO THE CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO: TENANTS PERSONAL PROPERTY OF EVERY
KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF
EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS
LEASE OR ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR
CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST LANDLORD IN CONNECTION WITH
THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF LANDLORD’S OFFICERS,
DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. 

37. Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or future laws, then and
in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. It is also the intention of the parties to this Lease that in lieu of each clause or provision of this Lease that is illegal,
invalid or unenforceable, there be added, as a part of this Lease, a clause or provision as similar in effect to such illegal, invalid or unenforceable clause or provision as shall be legal, valid and enforceable. 

38. Signs; Exterior Appearance. Tenant shall not, without the prior written consent of Landlord, which may be granted or withheld in
Landlord’s reasonable discretion: (i) attach any awnings, exterior lights, decorations, balloons, flags, pennants, banners, painting or other projection to any outside wall of the Project, (ii) use any curtains, blinds, shades or
screens other than Landlord’s standard window coverings, (iii) coat or otherwise sunscreen the interior or exterior of any windows, (iv) place any bottles, parcels, or other articles on the window sills, (v) place any equipment,
furniture or other items of personal property on any exterior balcony, or (vi) paint, affix or exhibit on any part of the Premises or the Project any signs, notices, window or door lettering, placards, decorations, or advertising media of any
type which can be viewed from the exterior of the Premises. Interior signs on doors and the directory tablet shall be inscribed, painted or affixed for Tenant by Landlord at the sole cost and expense of Tenant, and shall be of a size, color and type
acceptable to Landlord. Nothing may be placed on the exterior of corridor walls or corridor doors other than Landlord’s standard lettering. The directory tablet shall be provided exclusively for the display of the name and location of tenants.

  
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 Subject to the terms and conditions of this Section 38. Tenant shall have the
non-exclusive right to display, at Tenant’s sole cost and expense, one (1) sign bearing Tenant’s name and logo on the building top above the entrance of the Premises on the south side of the Building and otherwise in a location
reasonably acceptable to Landlord (“Building Sign”). Subject to the terms and conditions of this Section 38, Tenant shall also have the non-exclusive right to display, at Tenant’s sole cost and expense, signage
bearing Tenant’s name and logo on the monument sign serving the Project (the “Monument Sign”). Tenant further acknowledges and agrees that Tenant’s signage on the Monument Sign and the Building Sign including, without
limitation, the location, size, color and type, shall be subject to Landlord’s prior written approval, which shall not be unreasonably withheld and shall comply with Landlord’s signage program at the Project and with applicable Legal
Requirements. Tenant shall be responsible, at Tenant’s sole cost and expense, for the maintenance of Tenant’s signage on the Monument Sign and the Building Sign, for the removal of Tenant’s signage from the Monument Sign and the
Building Sign at the expiration or earlier termination of this Lease and for the repair all damage resulting from such removal. 
 39.
Right to Extend Term. Tenant shall have the right to extend the Term of the Lease upon the following terms and conditions: 
 (a)
Extension Right. Tenant shall have 1 right (the “Extension Right”) to extend the term of this Lease for 3 years (the “Extension Term”) on the same terms and conditions as this Lease (other than with respect
to Base Rent and the Work Letter) by giving Landlord written notice of its election to exercise each Extension Right at least 9 months prior to the expiration of the Base Term of the Lease. 

Upon the commencement of the Extension Term, Base Rent shall be payable at the Market Rate (as defined below). Base Rent shall thereafter be
adjusted on each annual anniversary of the commencement of such Extension Term by a percentage as determined by Landlord and agreed to by Tenant at the time the Market Rate is determined. As used herein, “Market Rate” shall mean the
rate that comparable landlords of comparable buildings have accepted in current transactions from non-equity (i.e., not being offered equity in the buildings) and nonaffiliated tenants of similar financial strength for space of comparable size,
quality (including all Tenant Improvements, Alterations and other improvements) and floor height in Class A laboratory/office buildings in the Central San Diego submarket for a comparable term, with the determination of the Market Rate to take
into account all relevant factors, including tenant inducements, views, available amenities (including, without limitation, the Amenities (as defined in Section 42 below), age of the Building, age of mechanical systems serving the
Premises, parking costs, leasing commissions, allowances or concessions, if any. In addition, Landlord may impose a market rent for the parking rights provided hereunder. Notwithstanding anything to the contrary contained in this
Section 39(a), if Tenant exercises its Extension Right pursuant to this Section 39. Landlord shall make available to Tenant an allowance in the maximum amount of $25.00 per rentable square foot of the Premises for fixed and
permanent improvements desired by Tenant in the Premises and reasonably acceptable to Landlord. 
 If, on or before the date which is 240
days prior to the expiration of the Base Term of this Lease, Tenant has not agreed with Landlord’s determination of the Market Rate and the rent escalations during the Extension Term after negotiating in good faith, Tenant shall be deemed to
have elected arbitration as described in Section 39(b). Tenant acknowledges and agrees that, if Tenant has elected 

  
 37 

 
to exercise the Extension Right by delivering notice to Landlord as required in this Section 39(a), Tenant shall have no right thereafter to rescind or elect not to extend the term of
the Lease for the Extension Term. 
 (b) Arbitration. 

(i) Within 10 days of Tenant’s notice to Landlord of its election (or deemed election) to arbitrate Market Rate and escalations, each
party shall deliver to the other a proposal containing the Market Rate and escalations that the submitting party believes to be correct (“Extension Proposal”). If either party fails to timely submit an Extension Proposal, the other
party’s submitted proposal shall determine the Base Rent and escalations for the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after delivery of the last Extension Proposal and
make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate and escalations. If Landlord and Tenant are unable to agree upon a single Arbitrator, then each shall, by written notice delivered to
the other within 10 days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal shall determine the Base Rent for the Extension Term. The 2
Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If the 2 Arbitrators so selected cannot agree on the selection of the third Arbitrator within the time above specified, then either party, on
behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the Premises are located, upon 10 days prior written notice to the other party of
such intent. 
 (ii) The decision of the Arbitrator(s) shall be made within 30 days after the appointment of a single Arbitrator or the
third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and binding upon the parties. Each party shall
pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate and escalations are not determined by the first day of
the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by the Rent Adjustment Percentage until such determination is made. After the
determination of the Market Rate and escalations, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Market Rate and escalations for the Extension
Term. 
 (iii) An “Arbitrator” shall be any person appointed by or on behalf of either party or appointed pursuant to the
provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech industrial real estate in the greater San
Diego metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of high tech or life sciences space in the greater San Diego metropolitan area,
(ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and disinterested. 

  
 38 

 (c) Rights Personal. The Extension Right is personal to Tenant and is not assignable
without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease, except that they may be assigned in
connection with any Permitted Assignment of this Lease. 
 (d) Exceptions. Notwithstanding anything set forth above to the contrary,
the Extension Right shall, at Landlord’s option, not be in effect and Tenant may not exercise the Extension Right: 
 (i) during any
period of time that Tenant is in Default under any provision of this Lease; or 
 (ii) if Tenant has been in Default under any provision of
this Lease 3 or more times, whether or not the Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise an Extension Right, whether or not the Defaults are cured. 

(e) No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or enlarged by reason of
Tenant’s inability to exercise the Extension Right. 
 (f) Termination. The Extension Right shall, at Landlord’s option,
terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term, (i) Tenant fails to timely cure any
default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the Extension Term, whether or not such Defaults are
cured. 
 40. Early Termination Right. Tenant shall have the right, subject to the provisions of this Section 40, to
terminate this Lease (“Termination Right”) with respect to the entire Premises only on the last day of the 30th full calendar month after the Commencement Date (“Early
Termination Date”), so long as Tenant delivers to Landlord (a) a written notice (“Termination Notice”), of its election to exercise its Termination Right no less than 9 months in advance of the Early Termination Date,
and (b) concurrent with Tenant’s delivery of the Termination Notice to Landlord, an early termination payment in the amount of $150,000 (collectively, the “Early Termination Payment”). If Tenant timely and properly
exercises the Termination Right and delivers the Early Termination Payment, Tenant shall vacate the Premises and deliver possession thereof to Landlord in the condition required by the terms of this Lease on or before the Early Termination Date and
Tenant shall have no further obligations under this Lease after the Early Termination Date except for those accruing prior to the Early Termination Date and those which, pursuant to the terms of this Lease, survive the expiration or early
termination of this Lease. 
 If Tenant delivers a Termination Notice to Landlord pursuant to immediately preceding paragraph, Landlord
shall have the opportunity, if it so elects and without any obligation to do so, to offer one or more alternative premises for lease to Tenant which reasonably satisfies the premises being sought by Tenant following the Early Termination Date
(“Alternative Premises”). Such Alternative Premises shall be located at the Project or, if Landlord so elects, at another property in the San Diego area owned or controlled by an entity controlled by, under common control with, or
controlling Landlord including, without limitation, any of the constituent members of Landlord or Alexandria Real Estate Equities, Inc. (any such entity, an “Affiliate”). Alternatively, Landlord and/or any Affiliate, as the case may
be, shall have the right, if it so elects and without any obligation to do so, to acquire a new project 

  
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or redevelop any existing project it then owns to offer to Tenant the Alternative Premises. Such new lease shall, if entered into, otherwise be upon terms and conditions acceptable to Landlord or
Affiliate, as the case may be, and Tenant in their respective good faith sole discretion. Tenant agrees to evaluate any such offer by Landlord (or its Affiliate) in good faith. 

41. Intentionally Omitted. 

42. The Alexandria Amenities. 

(a) Generally. ARE-SD Region No, 17, LLC, a Delaware limited liability company (“The Alexandria Landlord”) has
constructed certain amenities at the property owned by The Alexandria Landlord located at 10996 Torreyana Road, San Diego, California (“The Alexandria”), which, as of the date of this Lease, include, without limitation, shared
conference facilities (“Shared Conference Facilities”), a fitness center and restaurant (collectively, the “Amenities”) for non-exclusive use by (a) Tenant, (b) other tenants of the Project,
(c) Landlord, (d) the tenants of The Alexandria Landlord, (e) The Alexandria Landlord, (e) other affiliates of Landlord, The Alexandria Landlord and Alexandria Real Estate Equities, Inc. (“ARE”), (f) the
tenants of such other affiliates of Landlord, The Alexandria Landlord and ARE, and (g) any other parties permitted by The Alexandria Landlord (collectively, “Users”). Landlord, The Alexandria Landlord, ARE, and all affiliates
of Landlord, Alexandria Landlord and ARE may be referred to collectively herein as the “ARE Parties.” Notwithstanding anything to the contrary contained herein, Tenant acknowledges and agrees that The Alexandria Landlord shall have
the right, at the sole discretion of The Alexandria Landlord, to not make the Amenities available for use by some or all currently contemplated Users (including Tenant). The Alexandria Landlord shall have the sole right to determine all matters
related to the Amenities including, without limitation, relating to the reconfiguration, relocation, modification or removal of any of the Amenities at The Alexandria and/or to revise, expand or discontinue any of the services (if any) provided in
connection with the Amenities. Tenant acknowledges and agrees that Landlord has not made any representations or warranties regarding the availability of the Amenities and that Tenant is not entering into this Lease relying on the continued
availability of the Amenities to Tenant. 
 (b) License. Commencing on the Commencement Date, and so long as The Alexandria and the
Project continue to be owned by affiliates of ARE, Tenant shall have the non-exclusive right to the use of the available Amenities in common with other Users pursuant to the terms of this Section 42. Tenant shall be entitled to 2.5
passes to the fitness center located at The Alexandria per 1,000 rentable square feet of the Premises for use by employees of Tenant employed at the Premises. If any employee of Tenant to whom a fitness center pass has been issued ceases to be an
employee of Tenant at the Premises or any employee to whom an access card (which does not include a fitness center pass) has been issued ceases to be an employee of Tenant at the Premises, Tenant shall immediately upon such employee’s change in
status collect such employee’s pass or access card, as applicable, and deliver it to Landlord along with written notice of such employee’s change in status. 

Commencing on the Commencement Date, Tenant shall pay to Landlord a fixed fee during the Base Term equal to $0.12 per rentable square foot of
the Premises per month (“Amenities Fee”), which Amenities Fee shall by payable on the first day of each month during the Term whether or not Tenant elects to use any or all of the Amenities. The Amenities Fee shall be increased
annually on each anniversary of the Commencement Date by 3%. With respect to the Extension Term, if exercised by Tenant, Landlord may impose a market fee in connection with the Amenities. If all of the Amenities at The Alexandria become materially
unavailable for use by Tenant 

  
 40 

 
(for any reason other than a Default by Tenant under this Lease or the default by Tenant of any agreement(s) relating to the use of the Amenities by Tenant) for a period in excess of 90
consecutive days, then, commencing on the date that the Amenities in their entirety become materially unavailable for use by Tenant and continuing for the period that the Amenities in their entirety remain materially unavailable for use by Tenant,
the Amenities Fee then-currently payable by Tenant shall be abated. 
 (c) Shared Conference Facilities. Use by Tenant of the Shared
Conference Facilities and restaurant at The Alexandria shall be in common with other Users with scheduling procedures reasonably determined by The Alexandria Landlord or The Alexandria Landlord’s then designated event operator (“Event
Operator”). Tenant’s use of the Shared Conference Facilities shall be subject to the payment by Tenant to The Alexandria Landlord of a fee equal to The Alexandria Landlord’s quoted rates for the usage of the Shared Conference
Facilities in effect at the time of Tenant’s scheduling discounted by 30%. Tenant’s use of the conference rooms in the Shared Conference Area shall be subject to availability and The Alexandria Landlord (or, if applicable, Event Operator)
reserves the right to exercise its reasonable discretion in the event of conflicting scheduling requests among Users. Tenant hereby acknowledges that (i) Biocom/San Diego, a California non-profit corporation (“Biocom”) has the
right to reserve the Shared Conference Facilities and any reservable dining area(s) included within the Amenities for up to 50% of the time that such Shared Conference Facilities and reservable dining area(s) are available for use by Users each
calendar month, and (ii) lllumina, Inc., a Delaware corporation, has the exclusive use of the main conference room within the Shared Conference Facilities for up to 4 days per calendar month. 

Tenant shall be required to use the food service operator designated by The Alexandria Landlord at The Alexandria (the “Designated
Food and Beverage Operator”) for any food and/or beverage service or catered events held by Tenant in the Shared Conference Facilities. As of the date of this Lease, the Designated Food and Beverage Operator is The Farmer and the Seahorse.
The Alexandria Landlord has the right, in its sole and absolute discretion, to change the Designated Food and Beverage Operator at any time. Tenant may not use any vendors other than the Designated Food and Beverage Operator nor may Tenant supply
its own food and/or beverages in connection with any food and/or beverage service or catered events held by Tenant in the Shared Conference Facilities. 

Tenant shall, at Tenant’s sole cost and expense, (i) be responsible for the set-up of the Shared Conference Facilities in connection
with Tenant’s use (including, without limitation ensuring that Tenant has a sufficient number of chairs and tables and the appropriate equipment), and (ii) surrender the Shared Conference Facilities after each time that Tenant uses the
Shared Conference Facilities free of Tenant’s personal property, in substantially the same set up and same condition as received, subject to casualty, and free of any debris and trash. If Tenant fails to restore and surrender the Shared
Conference Facilities as required by sub-section (ii) of the immediately preceding sentence, such failure shall constitute a “Shared Facilities Default.” Each time that Landlord reasonably determines that Tenant has committed a
Shared Facilities Default, Tenant shall be required to pay Landlord a penalty within 5 days after notice from Landlord of such Shared Facilities Default. The penalty payable by Tenant in connection with the first Shared Facilities Default shall be
$200. The penalty payable shall increase by $50 for each subsequent Shared Facilities Default (for the avoidance of doubt, the penalty shall be $250 for the second Shared Facilities Default, shall be $300 for the third Shared Facilities Default,
etc.). In addition to the foregoing, Tenant shall be responsible for reimbursing The Alexandria Landlord or Landlord, as applicable, for all costs expended by The Alexandria Landlord or Landlord, as applicable, in repairing any damage to the Shared
Conference Facilities, the Amenities, or The Alexandria caused by Tenant or any Tenant Related Party. The provisions of this Section 42(c) shall survive the expiration or earlier termination of this Lease. 

  
 41 

 (d) Restaurant. Tenant’s employees that have been issued an access card to The
Alexandria shall have the right, along with other Users, to access and use the restaurant located at The Alexandria. All such employees of Tenant shall be entitled to a 20% discount on certain food items (not including alcohol) purchased at the
restaurant (on an individual basis and not with respect to entire tables or checks), which discount shall not be transferrable. 
 (e)
Rules and Regulations. Tenant shall be solely responsible for paying for any and all ancillary services (e.g., audio visual equipment) provided to Tenant, all food services operators and any other third party vendors providing services to
Tenant at The Alexandria. Tenant shall use the Amenities (including, without limitation, the Shared Conference Facilities) in compliance with all applicable Legal Requirements and any rules and regulations imposed by The Alexandria Landlord or
Landlord from time to time and in a manner that will not interfere with the rights of other Users. The use of Amenities other than the Shared Conference Facilities by employees of Tenant shall be in accordance with the terms and conditions of the
standard licenses, indemnification and waiver agreement required by The Alexandria Landlord or the operator of the Amenities to be executed by all persons wishing to use such Amenities. Neither The Alexandria Landlord nor Landlord (nor, If
applicable, any other affiliate of Landlord) shall have any liability or obligation for the breach of any rules or regulations by other Users with respect to the Amenities. Tenant shall not make any alterations, additions, or improvements of any
kind to the Shared Conference Facilities, the Amenities or The Alexandria. 
 Tenant acknowledges and agrees that The Alexandria Landlord
shall have the right at any time and from time to time to reconfigure, relocate, modify or remove any of the Amenities at The Alexandria and/or to revise, expand or discontinue any of the services (if any) provided in connection with the Amenities.

 (f) Waiver of Liability and Indemnification. Tenant warrants that it will use reasonable care to prevent damage to property and
injury to persons while on The Alexandria. Tenant waives any claims it or any Tenant Parties may have against any ARE Parties relating to, arising out of or in connection with the Amenities and any entry by Tenant and/or any Tenant Parties onto The
Alexandria, and Tenant releases and exculpates all ARE Parties from any liability relating to, arising out of or in connection with the Amenities and any entry by Tenant and/or any Tenant Parties onto The Alexandria. Tenant hereby agrees to
indemnify, defend, and hold harmless the ARE Parties from any claim of damage to property or injury to person relating to, arising out of or in connection with (i) the use of the Amenities by Tenant or any Tenant Parties, and (ii) any
entry by Tenant and/or any Tenant Parties onto The Alexandria, except to the extent caused by the gross negligence or willful misconduct of any ARE Parties. The provisions of this Section 42 shall survive the expiration or earlier
termination of this Lease. 
 (g) Insurance. As of the Amenities Commencement Date, Tenant shall cause The Alexandria Landlord to be
named as an additional insured under the commercial general liability policy of insurance that Tenant is required to maintain pursuant to Section 17 of this Lease. 

  
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 43. Asbestos. 

(a) Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials
(“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the location Identified in Exhibit H. 

(b) Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (a) of this
Section 43 and understands that the purpose of such notification is to make Tenant and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order to avoid or
minimize any damage to or disturbance of such ACMs and/or PACMs. 
  
  

 
 (c) Acknowledgement from Contractors/Employees. Tenant shall give Landlord at least 14
days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify or describe
the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to determine
whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval. Upon Landlord’s request, Tenant
shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within or about the Premises in the locations identified
in Exhibit H prior to the commencement of such activities. Nothing in this Section 43 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct, authorize or permit any such activities. 

(i) Removal of thermal system insulation (“TSI”) and surfacing ACMs and PACMs (i.e., sprayed-on or troweled-on material,
e.g., textured ceiling paint or fireproofing material); 
 (ii) Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or

 (iii) Repair and maintenance of operations that are likely to disturb ACMs or PACMs. 

44. Miscellaneous. 

(a) Notices. All notices or other communications between the parties shall be in writing and shall be deemed duly given, upon
delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty courier, addressed and sent to the parties at their addresses set forth above. Landlord and
Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 
 (b) Joint and
Several Liability. If and when included within the term “Tenant,” as used in this instrument, there is more than one person or entity, each shall be jointly and severally liable for the obligations of Tenant. 

  
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 (c) Financial Information. Tenant shall furnish Landlord with true and complete copies of
(i) Tenant’s most recent audited annual financial statements within 120 days of the end of each of Tenant’s fiscal years during the Term, (ii) Tenant’s most recent unaudited quarterly financial statements within 55 days of
the end of each of Tenant’s first three fiscal quarters of each of Tenant’s fiscal years during the Term, (iii) at Landlord’s request from time to time, updated business plans, including cash flow projections and/or pro forma
balance sheets and income statements, all of which shall be treated by Landlord as confidential information belonging to Tenant, and (iv) corporate brochures and/or profiles prepared by Tenant for prospective investors. Landlord shall treat
Tenant’s financial information as confidential information belonging to Tenant and will not disclose the same to third parties other than on a need-to-know basis to Landlord’s affiliates, legal, financial or tax advisors, consultants,
potential lenders and potential purchasers (and Landlord shall instruct such parties to keep such financial information confidential) and as required by Legal Requirements. 

(d) Recordation. Neither this Lease nor a memorandum of lease shall be filed by or on behalf of Tenant in any public record. Landlord
may prepare and file, and upon request by Landlord Tenant will execute, a memorandum of lease. 
 (e) Interpretation. The normal rule
of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. Words of any gender used in this Lease shall be held and
construed to include any other gender, and words in the singular number shall be held to include the plural, unless the context otherwise requires. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise
describe the scope or intent of this Lease, or any provision hereof, or in any way affect the interpretation of this Lease. 
 (f) Not
Binding Until Executed. The submission by Landlord to Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party
until execution of this Lease by both parties. 
 (g) Limitations on Interest. It is expressly the intent of Landlord and Tenant at
all times to comply with applicable law governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest called for under this
Lease, or contracted for, charged, taken, reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on the applicable
obligation (or, If the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without the necessity
of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 

(h) Choice of Law. Construction and interpretation of this Lease shall be governed by the internal laws of the state in which the
Premises are located, excluding any principles of conflicts of laws. 
 (i) Time. Time is of the essence as to the performance of
Tenant’s obligations under this Lease. 

  
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 (j) OFAC. Tenant and all beneficial owners of Tenant are currently (a) in compliance
with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation
relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List, Foreign Sanctions Evaders List, or the
Sectoral Sanctions Identification List, which are all maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a
person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules. 
 (k) Incorporation by
Reference. All exhibits and addenda attached hereto are hereby incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control.

 (l) Entire Agreement. This Lease, including the exhibits attached hereto, constitutes the entire agreement between Landlord and
Tenant pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings, letters of intent, negotiations and discussions, whether oral or written, of the parties, and there are no warranties,
representations or other agreements, express or implied, made to either party by the other party in connection with the subject matter hereof except as specifically set forth herein. 

(m) No Accord and Satisfaction. No payment by Tenant or receipt by Landlord of a lesser amount than the monthly installment of Base
Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or letter accompanying a check for payment of any Base Rent or Additional Rent be
an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any other remedy provided in this Lease. 

(n) Hazardous Activities. Notwithstanding any other provision of this Lease, Landlord, for itself and its employees, agents and
contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to Tenant’s routine safety guidelines, practices or custom or prudent industry practices, require any form of protective
clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are acceptable to Landlord, in Landlord’s reasonable discretion, for all such repairs and services, and Landlord shall, to the extent
required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that Landlord is not providing such repairs or services to Tenant. 

(o) Redevelopment of Project. Tenant acknowledges that Landlord, in its sole discretion, may from time to time expand, renovate and/or
reconfigure the Project as the same may exist from time to time and, in connection therewith or in addition thereto, as the case may be, from time to time without limitation: (a) change the shape, size, location, number and/or extent of any
improvements, buildings, structures, lobbies, hallways, entrances, exits, parking and/or parking areas relative to any portion of the Project; (b) modify, eliminate and/or add any buildings, improvements, and parking structure(s) either above
or below grade, to the Project, the Common Areas and/or any other portion of the Project and/or make any other changes thereto affecting the same; and (c) make any other changes, additions and/or deletions in any way affecting the Project
and/or any portion thereof as Landlord may elect from time to time, including without limitation, additions to and/or deletions from the land comprising the Project, the Common Areas and/or any 

  
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other portion of the Project. Notwithstanding anything to the contrary contained in this Lease, Tenant shall have no right to seek damages (including abatement of Rent) or to cancel or terminate
this Lease because of any proposed changes, expansion, renovation or reconfiguration of the Project nor shall Tenant have the right to restrict, inhibit or prohibit any such changes, expansion, renovation or reconfiguration; provided, however,
Landlord shall not change the size, dimensions, location or Tenant’s Permitted Use of the Premises. 
 (p) Discontinued Use. If,
at any time following the Rent Commencement Date, Tenant does not continuously operate its business in the Premises for a period of 180 consecutive days (excluding closures required due to casualty), Landlord may, but is not obligated to, elect to
terminate this Lease upon 30 days’ written notice to Tenant, whereupon this Lease shall terminate 30 days’ after Landlord’s delivery of such written notice (“Termination Date”), and Tenant shall vacate the Premises
and deliver possession thereof to Landlord in the condition required by the terms of this Lease on or before the Termination Date and Tenant shall have no further obligations under this Lease except for those accruing prior to the Termination Date
and those which, pursuant to the terms of the Lease, survive the expiration or early termination of the Lease. 
 (q) EV Charging
Stations. Landlord shall not unreasonably withhold its consent to Tenant’s written request to install 1 or more electric vehicle car charging stations {“EV Stations”) in the parking area serving the Project;
provided, however, that Tenant complies with all reasonable requirements, standards, rules and regulations which may be imposed by Landlord, at the time Landlord’s consent is granted, in connection with Tenant’s installation, maintenance,
repair and operation of such EV Stations, which may include, without limitation, the charge to Tenant of a reasonable monthly rental amount for the parking spaces used by Tenant for such EV Stations, Landlord’s designation of the location of
Tenant’s EV Stations, and Tenant’s payment of all costs whether incurred by Landlord or Tenant in connection with the installation, maintenance, repair and operation of each Tenant’s EV Station(s). Nothing contained in this paragraph
is intended to increase the number of parking spaces which Tenant is otherwise entitled to use at the Project under Section 10 of this Lease nor impose any additional obligations on Landlord with respect to Tenant’s parking rights
at the Project. 
 (r) California Accessibility Disclosure. For purposes of Section 1938(a) of the California Civil Code,
Landlord hereby discloses to Tenant, and Tenant hereby acknowledges, that the Project has not undergone inspection by a Certified Access Specialist (CASp). In addition, the following notice is hereby provided pursuant to Section 1938(e) of the
California Civil Code: “A Certified Access Specialist (CASp) can inspect the subject premises and determine whether the subject premises comply with all of the applicable construction-related accessibility standards under state law. Although
state law does not require a CASp inspection of the subject premises, the commercial property owner or lessor may not prohibit the lessee or tenant from obtaining a CASp inspection of the subject premises for the occupancy or potential occupancy of
the lessee or tenant, if requested by the lessee or tenant. The parties shall mutually agree on the arrangements for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs
necessary to correct violations of construction-related accessibility standards within the premises.” In furtherance of and in connection with such notice: (i) Tenant, having read such notice and understanding Tenant’s right to
request and obtain a CASp inspection, hereby elects not to obtain such CASp inspection and forever waives its rights to obtain a CASp inspection with respect to the Premises, Building and/or Project to the extent permitted by Legal Requirements; and
(ii) if the waiver set 

  
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forth in clause (i) hereinabove is not enforceable pursuant to Legal Requirements, then Landlord and Tenant hereby agree as follows (which constitutes the mutual agreement of the parties as
to the matters described in the last sentence of the foregoing notice): (A) Tenant shall have the one-time right to request for and obtain a CASp inspection, which request must be made, if at all, In a written notice delivered by Tenant to
Landlord; (B) any CASp inspection timely requested by Tenant shall be conducted (1) at a time mutually agreed to by Landlord and Tenant, (2) in a professional manner by a CASp designated by Landlord and without any testing that would
damage the Premises, Building or Project in any way, and (3) at Tenant’s sole cost and expense, including, without limitation, Tenant’s payment of the fee for such CASp Inspection, the fee for any reports prepared by the CASp in
connection with such CASp inspection (collectively, the “CASp Reports”) and all other costs and expenses in connection therewith; (C) the CASp Reports shall be delivered by the CASp simultaneously to Landlord and Tenant;
(D) Tenant, at its sole cost and expense, shall be responsible for making any improvements, alterations, modifications and/or repairs to or within the Premises to correct violations of construction-related accessibility standards including,
without limitation, any violations disclosed by such CASp Inspection; and (E) if such CASp inspection identifies any improvements, alterations, modifications and/or repairs necessary to correct violations of construction-related accessibility
standards relating to those items of the Building and Project located outside the Premises that are Landlord’s obligation to repair as set forth in this Lease, then Landlord shall perform such improvements, alterations, modifications and/or
repairs as and to the extent required by Legal Requirements to correct such violations, and Tenant shall reimburse Landlord for the cost of such improvements, alterations, modifications and/or repairs within 10 business days after Tenant’s
receipt of an invoice therefor from Landlord. 
 [Signatures are on the next page] 

  
 47 

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year
first above written. 
  
  

									
	TENANT:
	
	 XERIS PHARMACEUTICALS, INC.,

a Delaware corporation

		
	By:	 	 /s/ John Shannon

	Its:	 	         COO

	
	LANDLORD:
	
	 ARE-SD REGION NO. 30, LLC,
 a
Delaware limited liability company

		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership,

managing member

			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
			
		 		 	By: /s/ Gary
Dean                                        

		 		 	Its:  Senior Vice President RE Legal Affairs

  

  
 48 

 EXHIBIT A TO LEASE 

DESCRIPTION OF PREMISES 
  

 

  
 49 

 EXHIBIT B TO LEASE 

DESCRIPTION OF PROJECT 
  

 

  
 50 

 EXHIBIT C TO LEASE 

WORK LETTER 
 THIS WORK
LETTER dated September 29, 2017 (this “Work Letter”) is made and entered into by and between ARE-SD REGION NO.’30, LLC, a Delaware limited liability company (“Landlord”), and XER1S
PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”), and is attached to and made a part of the Lease Agreement dated September 29, 2017 (the “Lease”), by and between Landlord and Tenant. Any
initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
 1. General Requirements.

 (a) Tenant’s Authorized Representative. Tenant designates Steve Prestrelski and Dean Petersen (either such individual acting
alone, “Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication
(“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change either Tenant’s Representative at any time upon not
less than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the performance of Landlord’s Work (as hereinafter defined). 

(b) Landlord’s Authorized Representative. Landlord designates Chris Clement and Eric Hedblad (either such individual acting alone,
“Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication from or
on behalf of Landlord in connection with this Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any time upon not less than 5 business days advance
written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in the performance of Landlord’s Work. 

(c) Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that: (i) the general contractor and
any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld, conditioned or delayed, and (ii) MacFarlane Architects shall be the architect
(the “Tl Architect”) for the Tenant Improvements. 
 2. Tenant Improvements. 

(a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the Premises of
a fixed and permanent nature as shown on the Tl Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in Section 3(a) below), Landlord shall not have any obligation whatsoever
with respect to the finishing of the Premises for Tenant’s use and occupancy. Landlord and Tenant acknowledge and agree that a portion of the Premises, as reflected in the Space Plan, will not be improved as part of the Tenant Improvements as
Tenant has indicated that it does not require that such portion of the Premises be improved in connection with its operations in the Premises. Upon request from Tenant, Landlord shall provide Tenant with notice of planned meetings regarding the
design and construction of the tenant improvements. Tenant shall have a right to have a representative present for all design and construction meetings relating to the Tenant Improvements. 

  
 51 

 (b) Tenant’s Space Plans. Landlord and Tenant acknowledge and agree that the plan
prepared by the Tl Architect attached hereto as Schedule 1 (the “Space Plans”) and the Tl specifications attached hereto as Schedule 2 (the “Tl Specifications”) have been approved by both Landlord and
Tenant. Landlord and Tenant further acknowledge and agree that any Changes to the Space Plans or the Tl Specifications requested by Tenant constitute a Change Request the cost of which Changes shall be paid for by Tenant in accordance with
Section 5(b) below. Tenant shall be solely responsible, pursuant to the terms of Section 5fb) below, for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a result of
Tenant’s requested Changes. Notwithstanding anything to the contrary contained herein, Landlord is not required to make any Changes requested by Tenant to the Space Plans or the Tl Specifications. 

(c) Working Drawings. Landlord shall cause the Tl Architect to prepare and deliver construction plans, specifications and drawings for
the Tenant Improvements (“Tl Construction Drawings”) consistent with the Space Plans and the Tl Specifications. 
 (d)
Approval and Completion. Upon any dispute regarding the design of the Tenant Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Landlord may make the final decision
regarding the design of the Tenant Improvements. Any changes to the Tl Construction Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 

3. Performance of Landlord’s Work. 

(a) Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall mean the work of constructing the
Tenant Improvements. 
 Tenant shall be solely responsible for ensuring that the design and specifications for the Tenant Improvements are
consistent with Tenant’s requirements. Landlord shall be responsible for obtaining all permits, approvals and entitlements necessary for Landlord’s Work, but shall have no obligation to, and shall not, secure any permits, approvals or
entitlements related to Tenant’s specific use of the Premises or Tenant’s business operations therein. 
 (b) Commencement and
Permitting. Landlord shall commence construction of the Tenant Improvements upon obtaining a building permit (the “Tl Permit”) authorizing the construction of the Tenant Improvements consistent with the Tl Construction Drawings
approved by Tenant. The cost of obtaining the Tl Permit shall be payable by Landlord. Tenant shall reasonably assist Landlord in obtaining the Tl Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work
or any portion thereof shall impose terms or conditions upon the construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) materially increase the cost of constructing Landlord’s Work, or
(iii) will materially delay the construction of Landlord’s Work, Landlord and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. 

  
 52 

 (c) Completion of Landlord’s Work. Landlord shall substantially complete or cause to
be substantially completed Landlord’s Work in a good and workmanlike manner, in accordance with the Tl Permit subject, in each case, to Minor Variations and normal “punch list” items of a non-material nature that do not interfere with
the use of the Premises and with a certificate or temporary certificate of occupancy (or an equivalent approval having been issued) for the Premises permitting lawful occupancy of the Premises (but specifically excluding any permits, licenses or
other governmental approvals required to be obtained in connection with Tenant’s operations in the Premises) (“Substantial Completion” or “Substantially Complete”). Notwithstanding the foregoing,
Landlord’s Work shall not be considered Substantially Completed until the Walk-Through Inspection (as defined below) has been completed. Upon Substantial Completion of Landlord’s Work, Landlord shall require the Tl Architect and the
general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Work Letter,
“Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the Tl Permit); (ii) to comply
with any request by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or (iv) to make reasonable adjustments for field deviations or
conditions encountered during the construction of Landlord’s Work. Landlord shall provide Tenant notice of any such Minor Variations. For purposes of this Work Letter, “Walk-Through Inspection” shall mean that Landlord and
Tenant have together, within 1 business day after request from Landlord to do so, conducted a walk-through inspection of the Premises to create a punch list reasonably acceptable to Landlord and Tenant. 

(d) Selection of Materials. Where more than one type of material or structure is indicated on the Tl Construction Drawings approved by
Landlord and Tenant, the option will be selected at Landlord’s sole and absolute discretion. As to all building materials and equipment that Landlord is obligated to supply under this Work Letter, Landlord shall select the manufacturer thereof
in its sole and absolute discretion. 
 (e) Delivery of the Premises. When Landlord’s Work is Substantially Complete, subject to
the remaining terms and provisions of this Section 3(e), Tenant shall accept the Premises. Tenant’s taking possession and acceptance of the Premises shall not constitute a waiver of: (i) any warranty with respect to workmanship
(including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of Landlord’s Work with applicable Legal Requirements, or (iii) any claim that Landlord’s Work
was not completed substantially in accordance with the Tl Construction Drawings (subject to Minor Variations and such other changes as are permitted hereunder) (collectively, a “Construction Defect”). Tenant shall have one year
after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the responsible contractor to remedy any such Construction Defect within
30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite Landlord’s reasonable efforts, fails to remedy such Construction Defect within such 30-day period. If
contractor fails to remedy such Construction Defect within a reasonable time, Landlord shall use reasonable efforts to remedy the Construction Defect within 30 days unless such Construction Defect cannot reasonably be remedied in 30 days in which
case Landlord shall thereafter continue to diligently pursue such remedy. 
 Tenant shall be entitled to receive the benefit of all
construction warranties and manufacturer’s equipment warranties relating to equipment installed In the Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and suppliers of such equipment,
but the cost of any such extended warranties shall be borne solely by Tenant. Landlord shall promptly 

  
 53 

 
undertake and complete, or cause to be completed, all punch list items, and shall use reasonable efforts to complete such punch list items within 30 days after Substantial Completion. 

(f) Commencement Date Delay. Except as otherwise provided in the Lease, Delivery of the Premises shall occur when Landlord’s Work
has been Substantially Completed, except to the extent that completion of Landlord’s Work shall have been actually delayed by any one or more of the following causes (“Tenant Delay”): 

(i) Tenant’s Representative was not available within 3 business day following Landlord’s request to give or receive any
Communication or to take any other action required to be taken by Tenant hereunder; 
 (ii) Tenant’s request for Change Requests (as
defined in Section 4(a) below) whether or not any such Change Requests are actually performed; 
 (iii) Construction of any
Change Requests; 
 (iv) Tenant’s request for materials, finishes or installations requiring unusually long lead times, provided that
promptly after Landlord learns of such long lead times, Landlord informs Tenant that the requested items will require unusually long lead times; 

(v) Intentionally Deleted; 

(vi) Tenant’s delay in providing information critical to the normal progression of the Project within 1 business day following written
request from Landlord therefor which identifies the information being requested as critical to the normal progression of the Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after
receipt of any request for such information from Landlord; 
 (vii) Tenant’s delay in making payments to Landlord for Excess Tl Costs
(as defined in Section 5(b) below); or 
 (viii) Any other act or omission by Tenant or any Tenant Party (as defined in the
Lease), or persons employed by any of such persons that continues for more than 2 business days after Landlord’s written notice to Tenant. 

None of the time frames set forth above are intended to shorten any time periods otherwise provided for herein for the taking of any action by
Tenant. If Delivery is delayed for any of the foregoing reasons, then Landlord shall cause the Tl Architect to certify the date on which the Tenant Improvements would have been completed but for such Tenant Delay and such certified date shall be the
date of Delivery. 
 4. Changes. Any changes requested by Tenant to the Tenant Improvements shall be requested and instituted in
accordance with the provisions of this Section 4 and shall be subject to the written approval of Landlord and the Tl Architect, such approval not to be unreasonably withheld, conditioned or delayed. 

(a) Tenant’s Request For Changes. If Tenant shall request changes to the Tenant Improvements (“Changes”), Tenant
shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change 

  
 54 

 
Request”), which Change Request shall detail the nature and extent of any such Change. Such Change Request must be signed by Tenant’s Representative. Landlord shall, before
proceeding with any Change, use commercially reasonable efforts to respond to Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the architectural and engineering fees and costs that will be
incurred, to analyze such Change Request (which costs shall be paid for by Tenant to the extent actually incurred, whether or not such Change is implemented). Landlord shall thereafter submit to Tenant in writing, within 5 business days of receipt
of the Change Request (or such longer period of time as is reasonably required depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including, without limitation, architectural and engineering costs
and the period of time, if any, that the Change will extend the date on which Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work caused by a Change, including any suspension of
Landlord’s Work while any such Change is being evaluated and/or designed, shall be Tenant Delay. 
 (b) Implementation of
Changes. If Tenant: (i) approves in writing the cost or savings and the estimated extension in the time for completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess Tl Costs required in connection with
such Change, Landlord shall cause the approved Change to be instituted. Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the Tl Architect’s reasonable determination of the amount
of Tenant Delay in connection with such Change shall be final and binding on Landlord and Tenant, absent manifest error. 
 5. Costs.

 (a) Tl Costs. Landlord shall be responsible for the payment of all design, permits and construction costs in connection with the
construction of the Tenant Improvements, including, without limitation, the cost of preparing the Tl Construction Drawings and the Space Plans and Landlord’s out-of-pocket expenses (collectively, “Tl Costs”). Notwithstanding
anything to the contrary contained herein, Tl Costs shall not include (and Landlord shall not be responsible for the cost of) furniture, personal property or other non-Building system materials or equipment, including, but not limited to,
Tenant’s voice or data cabling, non-ducted biological safety cabinets and other scientific equipment not incorporated into the Tenant Improvements. Tenant has advised Landlord that Tenant has retained Hughes Marino, Inc. (“Tenant’s
Project Manager”) to provide consulting services to Tenant in connection with the Tenant Improvements. Landlord shall pay Tenant’s Project Manager a fee equal to $30,000 as part of Tl Costs. 

(b) Excess Tl Costs. Notwithstanding anything to the contrary contained herein, Tenant acknowledges and agrees that Landlord shall have
no responsibility for any costs arising from or related to Tenant’s Changes to the Space Plans or Tl Construction Drawings, Tenant Delays, the cost of Changes and Change Requests which would increase any of the costs anticipated by Landlord for
Landlord’s Work (collectively, “Excess Tl Costs”). Landlord shall provide Tenant with the line-item amount of any Excess Tl Costs incurred along with reasonable supporting evidence but, for the avoidance of any doubt, in no
event shall Landlord be required to provide Tenant with its budget for Landlord’s Work. Tenant shall deposit with Landlord, as a condition precedent to Landlord’s obligation to complete the Tenant Improvements, 100% of the Excess Tl Costs
within 5 business days after written request from Landlord. If Tenant fails to deposit any Excess Tl Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited
to, the right to interest at the Default Rate and the right to assess a late charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. 

  
 55 

 6. Tenant Access. 

(a) Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s sole risk and expense, to the
Premises (i) 45 days prior to the Commencement Date to perform any work (“Tenant’s Work”) required by Tenant other than Landlord’s Work, provided that such Tenant’s Work is coordinated with the Tl Architect and
the general contractor, and complies with the Lease and all other reasonable restrictions and conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe work in process; all such access
shall be during normal business hours or at such other times as are reasonably designated by Landlord. Notwithstanding the foregoing, Tenant shall have no right to enter onto the Premises or the Project unless and until Tenant shall deliver to
Landlord evidence reasonably satisfactory to Landlord demonstrating that any insurance reasonably required by Landlord in connection with such pre-commencement access (including, but not limited to, any insurance that Landlord may require pursuant
to the Lease) is in full force and effect. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord until completion of Landlord’s Work and acceptance thereof by Tenant. 

(b) No Interference. Neither Tenant nor any Tenant Party (as defined in the Lease) shall interfere with the performance of
Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord shall have the right to exclude Tenant and any Tenant Party from the Premises and the
Project until Substantial Completion of Landlord’s Work. 
 (c) No Acceptance of Premises. The fact that Tenant may, with
Landlord’s consent, enter into the Project prior to the date Landlord’s Work is Substantially Complete for the purpose of performing Tenant’s Work shall not be deemed an acceptance by Tenant of possession of the Premises, but in such
event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and against any loss of or damage to Tenant’s property, completed work, fixtures, equipment, materials or merchandise, and from
liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party, except to the extent caused by the willful misconduct or gross negligence of Landlord Indemnified Parties. 

7. Miscellaneous. 
 (a)
Consents. Whenever consent or approval of either party is required under this Work Letter, that party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to the contrary. 

(b) Modification. No modification, waiver or amendment of this Work Letter or of any of its conditions or provisions shall be binding
upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 
 (c) No Default Funding. In no event shall Landlord have
any obligation perform any Landlord’s Work during any period that Tenant is in Default under the Lease. 

  
 56 

 Schedule 1 

Space Plans 
  

 

  
 57 

 Schedule 2  

Tl Specifications 
 September 26,
2017 
 Xeris 
 3985 Sorrento Valley BIvd 

Basis of Design 
 Re: Outline Specification – Tenant
Improvement 
  

			
	 OVERVIEW
	  	 The project consists of approximately 17,105 rentable square feet on one level. The program areas for the project will be roughly as
follows:
 •  Approximately 6,944 net square feet of Lab and Lab Support space

•  Approximately 5,948 net square feet of Private & Open Office (includes open office
circulation)
 •  Approximately 2,420 net square feet of Common Areas (such as conference rooms,
break areas, reception/lobby, mail and copy room)

		
	 CODE COMPLAINCE
	  	 Design and construction shall conform to all Federal, State and Local current building codes and ordinances to include but is not limited
to:
 •  California Building Code

•  California Mechanical Code

•  California Plumbing Code

•  California Fire Code

•  California Electrical Code

•  Local Fire Department Regulations

•  National Fire Protection Code

•  Title 24, California Energy Efficiency Standards

•  California Division of Occupational Safety and Health

•  San Diego Municipal Code

		
	 LEED CERTIFICATION
	  	The design of the tenant improvements has no LEED certification requirements.
		
	 ROOFTOP EQUIPMENT
	  	All rooftop equipment will be screened with a minimum screen height required to meet city requirements. Cladding to be metal panels or siding finished to match the metal panels on the building.
		
	 INTERIOR PARTITIONS
	  	 •  Metal stud and drywall partitions per the tenant’s floor plan.
3-5/8” studs typical, 6” as required, gage and spacing as required by code, and Type X, 5/8” drywall. Standard Interior partitions penetrate ceiling grid by 6”.

•  Full height partitions, to the underside of structure, will be provided at all perimeters of lab
suites, conference rooms, restrooms and where sound/security requirements occur.
 •  Fire rated
assemblies as required by code, full height, tunnel or shaft wall construction as approved by code.

  
 58 

			
		  	 •  Backing is required in any walls where casework, appliances, equipment or
fixtures will be mounted and should be coordinated with the structural engineer to determine any specialty requirements for heavy loads.

•  Smooth drywall finish to Level 4 in finished areas.

		
	 INSULATION
	  	Batt insulation as required for sound control at conference rooms, restroom cores, equipment rooms, and private offices.
		
	 DOORS, FRAMES & HARDWARE
	  	 General

•  Hardware includes components and ratings as required by code.

•  Keying to be compatible with the Landlord’s master system

 
 Offices/General Use Area

•  Interior door assemblies are 3’x9’ or 6’x9’ pair, solid core,
wood veneer, flush face doors with no added urea-formaldehyde resins.
 •  sliding glass
doors or wood swing doors are 3’x9’at-off ices
 •  Anodized aluminum frames,
natural finish, 3’x9’ or 6’x9’ pair with full glazed fronts at offices and conference rooms.

•  Leverstyle, heavy duty, satin aluminum hardware.

•  Interior doors are passage locksets

 
 Lab/Lab Support/Equipment/Storage Areas

•  Door assemblies to be 3’x9’, 3’6”x9’,
6’x9’ or uneven pairs and match offices. Where function dictates painted hollow metal doors and fully welded frames will be provided.

•  Doors stained to match offices with vision lites as dictated by function.

•  Leverstyle, heavy duty, satin aluminum cylindrical passage latch-set and lockset (as dictated by
function) hardware and 34” high armor kick plates on the push side of doors.

		
	 WINDOWS
	  	Frames to match style of doorframes in office areas or hollow metal fully welded frames with function dictates,
		
	 CEILING SYSTEMS
	  	 General

•  Ceiling height to be 10’0”. All ceilings less than 10’0” require Landlord
review and approval prior to installation of overhead mechanical systems
 •  Gypsum
board or T-Bar suspension installation per code.
  
 Office Area

•  Armstrong 2’x2’ grid system, like 9/16” Suprafine with 1/8”
revel, white or similar
 •  Armstrong 2’x2’ acoustical tile, Calla #2824
NRC.85, white or similar
 •  Provide Axiom finish edge at perimeter where adjacent is open

•  Open office areas to be exposed to structure, cleaned, and painted or exposed wood
finish.

  
 59 

					
		  	 •  Lobby and Conference Rooms; combination of hard lid, soffits, and acoustical
tile
  
 Lab/Lab Support/Equipment/Storage Areas

•  Armstrong 2’x4’ 15/16” exposed T-Grid, white

•  Armstrong 2”x4’vinyl faced gypsum tiles or similar

 
 Hard lid — Gypsum board ceiling areas

•  Linear mechanical diffusers to be standard in hard lid areas.

		
	 WINDOW Coverings
	  	MechoShade Systems or equal roller shades, with manual controls, mounted within blind pocket.
		
	 MILLWORK/ LABORARY CASEWORK
	  	 Millwork

•  Construction Designation APA C-D plugged with exterior glue, 3/4” thick or3/4” high-
pressure particle board with no added urea-formaldehyde containing resins for Lunch and Break Rooms, Copy/Work Rooms and Conference Rooms

•  Adhesive compliant with Indoor Air Quality criteria per ASTM D-5116

•  Cabinets, countertops and splashes shall be plastic laminate finish and constructed in accordance
with WI Manual of Millwork
 •  Countertops in wet areas shall be solid surface or quartz

•  Self-closing hinges with vertical, horizontal and depth adjustment

•  Adjustable shelf standards, full extension, heavy-duty drawer glides

 
 Laboratory Casework

•  Lab casework shall be metal Hanson Lab Furniture, Thermo Fisher or equivalent, or plastic laminate
and constructed in accordance with WI Manual of Millwork, “Custom” grade

•  Self-closing hinges with vertical, horizontal and depth adjustment

•  Adjustable shelf standards, full extension, heavy duty drawer glides

•  Countertops in labs to be TRES PA, epoxy or equivalent

		
	 FLOOR COVERING
	  	 Genera!

•  All adhesives compliant with Indoor Air Quality criteria per ASTM D-5116

•  Flooring in laboratory areas extend wail to wall with casework set on top of flooring

 
 Office and Administration Areas

•  Exposed concrete, Broadloom or Carpet tile with a minimum allowance of $36,00 per square yard

•  Adhesives and floor prep per manufacturers recommendation

•  4” top set rubber base

 
 Lab/Lab Support/Equipment/Storage Areas

•  Vinyl Composition Tile, Armstrong or equivalent,12”x24”x1/8”

•  4” top set rubber base at walls and casework including
kneeholes

  
 60 

			
		
	 PAINT
	  	Paint shall not exceed the VOC and chemical component limits of Green Seal’s Standard GS-11.
		
	 RESTROOMS
	  	 Finishes in restrooms include:

•  Floors and wet walls to be finished with ceramic, porcelain or stone tile (full height on wet
walls)
 •  Solid surface countertops with full coverage plastic laminate aprons.

•  Stainless steel toilet partitions or approved equivalent by Landlord.

•  Stainless steel Bobrick accessories or approved equivalent by Landlord,

•  Drywall ceilings with recessed can lights and cove lighting above toilets, urinals and
mirrors

		
	 LAB SUPPORT EQUIPMENT
	  	 Landlord will provide the following:

•  Vacuum Pump

•  Air Compressor

•  Tenant to provide DIS kid, BSC s, and other lab equipment

		
	 SPECIALTIES
	  	 •  Stainless steel corner guards will be provided on the exterior corners of the
Lab and Lab Support areas
 •  Drying racks and paper towel dispensers will be provided at the Lab
and Lab Support sinks
 •  Dish washer in main lunch room

		
	 FIRE PROTECTION
	  	 Fire Sprinklers

•  Spacing and number of heads shall comply with recommendations of NFPA 13 for type of occupancy

•  Ceiling mounted high temperature heads (pendant, natural brass with chrome finish, semi-recessed
with matching adjustable metal escutcheon) shall be used in those areas required by tenant such as the Server Room.

•  Semi-Recessed, stainless steel fire extinguisher cabinets with dry chemical fire extinguisher
bottles as required by code: Sentry 5 or equivalent
 •  Concealed recessed pendants shall be
provided at all hard lid/gypsum board ceiling areas. Cap to be white or chrome dependent on application and as approved by Landlord,
  

Fire Alarm

•  Improvements to include all devices required by code and must be connected to the building fire
alarm system

  
 61 

			
	 PLUMBING - TENANT IMPROVEMENT MINIMUM CRITERIA

		
	 CODE COMPLIANCE
	  	 •  All work shall be in strict conformance with the following codes
&standards
 •  CA Plumbing Code

•  CA Building Code

•  CA Fire Code

•  Local Fire Department Regulations

•  National Fire Protection Association

•  All other Authorities Having Jurisdiction

•  All water fixtures used in general office space including restrooms but not including Process
Fixtures, shall exceed the minimum rating by 30% specified in the Energy Policy Act of 1992, in accordance with LEED calculations

•  Adhesives shall comply: VOC content shall be less than the current VOC content limits of SCAQMD
Rule #1168, AND all sealants used as fillers must meet to exceed the requirements of the South Coast Air Quality Management District Regulation 8, Rule 51

		
	 PRINCIPAL SYSTEMS
	  	 Principal Systems that may be Included in the Design

•  Sanitary sewer drain, waste &vent- all spaces above ground level drain by gravity to the
public sewer. To be field verified by new building layout.
 •  Industrial (Lab) waste
—connect to public sewer through sample port
 •  Compressed Air (CA) Compressor fed [Clean
Dry Air to be confirmed by tenant needs).
 •  Specialty gases, (N2, C02) Bottle fed

•  Lab Vacuum System

•  WaterSystems (ICW, IHW, DCW, DHW).

•  Purified water systems (Dl) to be via point of use units per tenant

•  Natural gas service to be provided to serve project needs, pending tk1sc review of site and
Landlord approval.
 •  If localized hot water is required, instantaneous electric domestic hot
water heaters may be used to serve lavatories and sinks in the, tenant suites
 •  Condensate drain
piping runs from the HVAC units to the nearest indirect waste receptor (max. 60” AFF.) or to a Janitor’s Sink

		
	 MATERIALS
	  	 •  Soil, Waste and Vent above Ground: Service-weight, no-hub cast-iron pipe and
fittings
 •  Soil, Waste and Vent Below Ground and to 5’-0” Outside of Building:
Service-weight cast-iron hub & spigot pipe and fittings
 •  Industrial (Lab) Waste and Vent
piping above ground to be plenum rated polypropylene DWV
 •  Industrial (Lab) Waste and Vent
piping below ground to be polypropylene DWV.

  
 62 

			
		  	 •  Industrial (Lab) Waste piping to route to a sample port just prior to connection
to sanitary system
 •  Water and Condensate Drain Piping Above Ground: Type “L”
hard-drawn copper type, ASTM B88, and wrought copper fittings, ANS I B1 6.22. All hot water supply piping shall be insulated with 1-1/2-inch thick fiberglass insulation for sizes up to 2-1/2 inch size, 2” inch thick above 2-inch size
piping. Condensate drain piping above ceilings to be insulated
 •  Water Piping Below Ground
4-inches and smaller: Type “K” hard-drawn copper tubing, ASTM B88, and wrought copper fittings ANS I B 16.22, silver brazed joints

•  Natural Gas Piping: Buried piping to be Polyethylene per ASTM D2513; above grade to be Schedule 40
black steel per ASTM D2513 Indirect Drains: Type “L” copper fittings, ANSI B16.22, solder joint type. Insulate with Manville Micro-Lok 650AP if temperature dictates

•  Specialty gas and lab vacuum piping shall be type L copper, silver brazed. C leaned and capped to
meet NFPA 99.
 •  Deionized Water: Pigmented polypropylene with IR fusion joints

•  Adhesives shall comply: VOC content shall be less than the current VOC content limits of SCAQMD
Rule sealants used as fillers must meet or exceed the requirements of the South Coast Air Quality Management District Regulation 8, Rule 51

		
	 PLUMBING EQUIPMENT
	  	 •  Domestic Water Heater; Domestic hot water will be provided by a combination
boiler and storage tank with circulation pump, expansion tank and master thermostatic mixing valve serving showers, lavatories, sinks and emergency showers,

•  Industrial Water Heater: Industrial hot water will be provided by a combination of boiler with
cupro Nickel heat exchanger for soft water service and storage tank with circulation pump and expansion tank serving cage washer, glass washers, sterilizers and laboratory sinks,

•  Air Compressor: Quadruplex open scroll clean dry air compressor with 100 psi distribution pressure
and air receive rand desiccant air dryer. Premium controls.
 •  Vacuum Pump Quadruplex lubricated
vane vacuum pump with 19” Hg distribution pressure with air receiver. Premium controls.

•  Dl Skid & Pretreatment (By Tenant): High Efficiency RO/DI system with ultralow pressure RO,
nominal 35 gpm. Estimated capacity 500 gallons per day. Shall include VFD distribution pumps, 500-gallon tank, UV sterilizers and final filters.

•  Bulk Gas Tanks (By Tenant)

•  Steam: electric steam generators provided by autoclave manufacturer

•  Water Closets, ADA Compliant Handicap-height, vitreous china, wall mounted, floor outlet,
low-flush toilet with flush valve
 •  Water Closet: Vitreous china, wall mounted, floor outlet,
low-flush toilet with flush valve
 •  Urinal, ADA Compliant: Wall hung, vitreous china, low-flush
urinal with flushometer. Mount at handicap height

  
 63 

			
		  	 •  Urinal; Wall hung, vitreous china, low-flush urinal with flushometer

•  Lavatory: Vitreous china wall hung lavatory with a single temperature-metering faucet

•  Faucet Infra-red sensor control restroom faucet on 120 v power

•  Lab sink: stainless steel or epoxy, sizes to be determined,

•  Lab Turrets: Bench and utility panel mount

•  Scullery sink; Double compartment stain less steel sink with 14 in. deep basin

•  Service Sink: Corner model, terrazzo mop service basin with vacuum breaker faucet Emergency
Shower/Eyewash: Guardian Model GBF2352 or equivalent
 •  Electric Water Cooler: Barrier-free, wall
hung water cooler with push bar control and equipped for handicap usage
 •  All water fixtures
used in general office space including restrooms but not including Process Fixtures, shall exceed the minimum average rating by 30% specified in the Energy Policy Act of 1992, in accordance with LEE D calculations

•  Break rooms shall have either double compartment 18-gauge stainless steel sinks.

		
	 DRAINS
	  	 •  FloorDrains: Cast iron body floor drains with nickel bronze top, membrane clamp
and adjustable collar
 •  FloorSinks: Cast iron body receptor with acid-resistant coated interior,
bottom dome strainer, seepage flange and grate

	
	 HVAC – TENANT IMPROVEMENT MINIMUM CRITERIA

		
	 CODE COMPLIANCE
	  	 •  All work shall be in strict conformance with the following codes and
standards
 •  CA Mechanical Code

•  CA Plumbing Code

•  CA Building Code

•  CA Fire Code

•  Local Fire Department Regulations

•  National Fire Protection Association

•  All other Authorities Having Jurisdiction

		
	 PRINCIPAL SYSTEMS
	  	 •  Summer-Winter HVAC systems for all occupied areas, including corridors and
restrooms
 •  Tenant spaces shall be conditioned by rooftop package units, All Laboratories will
be exhausted via utility sets.
 •  Fume hood and any bio-safety cabinet exhaust will be exhaust by
a high plume exhaust fan discharging at a minimum of 10 feet above the roof surface,
 •  A heating
hot water system will be provided to serve building heating or an equal alternate approved by the landlord.

  
 64 

			
		  	 •  Server room will be provided with an independent split system for 24/7
operation
 •  Toilet exhaust systems for all restrooms and janitor rooms per code

•  Building DDC controls based on an open source protocol (Bacnet). Siemens or Johnson Controls or
approved equivalent.

		
	 NEW HEATING PLANT AND GAS METER
	  	As part of the Tenant Improvement, a new natural gas heating plant shall be installed to provide all of Tenant’s heating requirements, Natural gas shall be supplied from a new dedicated gas meter.
		
	 OFFICE AREAS
	  	Rooftop package units will serve the office areas.
		
	 LAB AREAS
	  	These areas shall be serviced by rooftop 100% OSA packaged units equipped as described below. Space will either be zoned via Independent rooftop package units or via a larger rooftop unit with terminal boxes equipped with heating
hot water coils as approved by Landlord for budget purposes, The units shall be on the roof.
		
	 CRITICAL PROGRAM AREAS
	  	Areas that require continuous 7/24 operation (computer rooms, network server rooms, etc.) shall be considered for dedicated stand-alone air cooled DX systems. The system configuration shall be dependent on room capacity
requirements.
		
	 ROOFTOP
	  	 Custom Packaged Units with the following minimum components and accessories:

•  Double wall outdoor construction

•  Plenum supply fan(s) with high efficiency motors and VFD’s

•  Airflow monitoring stations

•  Moisture eliminator section

•  Filtration with 2 in. 30/30 pre-filters and 85% final filters as required,

•  Direct expansion cooling coil

•  Heating hot water coil.

•  Stainless steel drain pan

		
	 ENVIRONMENTAL DESIGN CONDITION
	  	 The following criteria will be used for sizing the heating and cooling systems:

•  Outdoor Ambient Design Conditions:

Summer: 91 F dB, 72° F mwB, 13° F dB outdoor daily range
Winter: 38° F dB

•  Indoor Conditions for Air Conditioned Area:

•  Offices, Labs: 72 F dB ±3 F dB, No Humidity Control

•  Electrical, Telecom, Storage: Typical of office space, unless equipment requires a more
specifically controlled environment
 •  Server Rooms: 68° F dB + 3 Db

  
 65 

			
	 VENTILATION AIR REQUIREMENTS
	  	 •  Outdoor air for ventilation will meet or exceed the requirements of the
American Society of Heating Ventilating and Air Conditioning
 •  Engineers (ASHRAE) Standard
62-1989, Ventilation for Acceptable Indoor Air Quality.
 •  For laboratory areas provide 100%
outside air. The following minimum air change requirements are recommended with night setback to be determined:

•  Biology Areas 6AC/Hr

•  Chemical Storage 15AC/Hr

		
	 ENERGY USE AND CONSERVATION
	  	The Energy Efficiency Standard, Title 24, to be used to set the minimum performance requirements of this installation
		
	 CEILING REGISTERS AND DIFFUSERS
	  	 •  Ceiling diffusers with perforated face with frame style compatible with the
type of ceiling used.
 •  Surface mounted diffusers require gaskets to prevent leakage. Diffuser
faceplate to have concealed hinges and latches. Faceplates to be easily removable from the frame.

•  Supply diffusers, Titus-PMC or equivalent perforated modular face-size 24” X 24” for
lay-in ceiling tile.
 •  Linear diffusers for all hard lid areas. Specialty diffusers by area as
required

		
	 DUCT WORK
	  	 •  Supply ducts, return ducts, and exhaust ducts plenum chambers, housing, and
panels fabricated from zinc-coated (galvanized) steel sheets conforming to the latest ASTM Specs A-525. Zinc-coating to be of the “Commercial” class

•  Exhaust branch duct from fume hoods shall be PVC coated galvanized or 304 stainless steel a
minimum of 10’ from main exhaust duct.
 •  Exhaust duct from Glasswash or Cagewash areas
shall be sloped 304 stainless steel a minimum of 10’ from main exhaust duct.

•  Ductwork shall be installed in strict accordance with the latest SMAC NA guidelines and shall also
adhere to the latest State and Federal seismic requirements.
 •  Install flexible ducts in a fully
extended condition free of sags and kinks, using minimum length required for connection. Flexible duct suspended on 36” centers with a min 3/4” wide flat banding material where horizontal support is required. Joints and connections to be
made in accordance with Underwriters Laboratories, Inc. Connect to rigid sheet metal with min 1/2” wide collar positively clamped and secured with screws or other approved fastening.

		
	 TOILET EXHAUST VENTILATION
	  	Exhaust all restrooms and janitor rooms with a minimum of 12 air changes per hour
		
	 MISC EXHAUST VENTILATION SYSTEMS
	  	 The following exhaust system will be installed as part of the shell design, it is assumed that outside ambient air shall provide makeup air
to the exhausted area:
 •  Main Electrical Room,

  
 66 

			
		
	 CONTROLS
	  	 •  Electronic DDC building automation system control the central plant
building core areas and tenant mechanical systems including zone temperature control. The system will operate the HVAC system and control occupied and non-occupied temperature and ventilation schedules. The system will include monitoring, alarm and
by-pass functions for efficient energy management

	
	 ELECTRICAL — TENANT IMPROVEMENT MINIMUM CRITERIA

		
	 CODE COMPLAINCE
	  	 All work shall be in strict conformance with the following codes and standards

•  NFPA 70 National Electrical Code

•  NFPA 101 Life Safety Code

•  BOCA Building Codes

•  IES - Illuminating Engineering Society of North America

		
	 DISTRIBUTION
	  	 •  SDG&E electrical room main distribution switchgear is existing to remain,
Existing service is 3000A at480Y/277V, 3 phase, 4 wire.
 •  There are two existing meters
available:
 •  Meter #1: 480V, 500A Service, Meter #5582943

•  Meter#2;-480V, 400A Service, Meter#6578928

•  All distribution will be from the main gear to each tenant’s dedicated electric
room(s).
 •  All conductors for new equipment to be installed as new

•  New HVAC equipment to be fed from new electrical panelboard(s),

•  Panelboards and distribution boards shall be located in the tenant’s electrical rooms
to feed the office/lab and support areas or within the lab area as appropriate,
 •  All new
transformers are energy efficient Energy Star type
 •  Tenant to provide 208V branch circuit
panelboards within the tenant space

		
	 DISTRIBUTION EQUIPMENT
	  	 Panelboards

•  All Panelboards to be new surface mounted and stacked if necessary, inside the dedicated
electrical rooms or flush mounted if outside the electrical room
 •  Panelboards for lighting to
be 480Y/277V 3j 4W to be fully rated for fault current. All Electrical panels are to be located in electrical equipment rooms or within the lab area as appropriate.

•  Panelboards for power and control power shall be 208Y/1Z0V
3j 4W with minimum fault current ratings of 10,000 AIC. Panelboards served through transformers shall have integral main over current protection, sized as indicated on the drawings.

•  All panelboards shall have, 42-pole space, bus ratings (as indicated on the panel schedules) and
are either surface or flush mounted (as Indicated on the panel schedules), All panels located in electrical rooms to be stacked or switchboard mounted to minimize space used by the panels

  
 67 

			
		  	 •  Panelboards with an isolated ground bus are required as noted. All 208Y/120V
3j 4W panelboards shall be provided with 100% rated neutral bus.
  

Feeders

•  Feeders shall be copper conductors (Type THHN or THW) routed in electro metallic tubing (EMT),
polyvinylchloride (PVC) conduit, or rigid galvanized steel (RGS) conduit. EMT shall be used in all indoor, concealed locations where the feeder is protected from damage or weather. RGS conduit shall be used in exterior applications or where the
conduit may be exposed to physical damage. PVC shall be used for all below-grade applications.

•  Feeders’ shall be sized according to the single line diagram in the construction
documents.
 •  Feeders shall be rack-mounted in accessible ceiling spaces or routed below grade
under the slab

		
	 EMERGENCY POWER SYSTEM
	  	 Emergency power systems are provided and maintained by Tenant Existing site generator and transfer switches are available for
tenant’s use if they choose.
 Existing generator shall meet the following requirements:

•  Existing generator tanks are sub-base mounted and provided as a complete package without grade or
in-grade fuel tank
 •  Existing generator is provided in a weather rated NE MA 3R enclosure and be
UL2200 compliant
 •  Existing generator to be standard sound attenuated enclosures rated if
required to reduce noise to 75 db at 23’ from enclosure

		
	 BRANCH CIRCUITRY
	  	 Conduit and Wire

•  Branch circuits for all power circuits serving furniture partition systems, office power,
convenience outlets, control power, etc. to be nominally sized as 120V 20A.
 •  Branch circuits
for lighting circuits to be either 27.7V 20A unless specifically indicated otherwise
 •  All Lab
area branch circuit conductors to be copper and routed in metal conduit.
 •  Each office to
include (2) duplex receptacles, and (1) ring and string devices per 130 SF office. Quantity to be adjusted per square footage room size. Controlled receptacles to be included as necessary per Title 24 requirements. Controlled receptacles are not
required when existing electrical service is maintained.
 •  Systems furniture feeds to.be
provided as (4) circuit{8) wire systems with three normal circuits and one dedicated circuit, Controlled receptacles to be included as necessary per Title 24 requirements. Controlled receptacles are not required when existing electrical service is
maintained.
 •  Branch circuits may be increased in size for specific loads or as necessary to
prevent excessive voltage drop on longer circuits.
 •  MC Cable to be provided for concealed areas
of routing as indicated on drawings,

  
 68 

			
		  	  
 Mechanical Equipment

•  Power provided from the 480 V or208 Y/120 V system for line voltage to mechanical equipment

•  Smoke detectors, time clocks, relays, contactors, etc, by the mechanical contractor.

•  Motor starters and disconnect switches by the electrical contractor according to the mechanical
equipment control wiring diagrams,

		
	 ELECTRICAL DEVICES
	  	 •  Electrical devices Including (receptacles and switches) shall be rated
according to the load served.
 •  Electrical devices shall be Decora type, white in color with
white thermoplastic cover plates.
 •  Cover plates for receptacles and junction boxes shall be
labeled indicating the circuit and panelboard from which the device is fed.
 •  All floor
furniture feeds shall be flush type or pedestal, and flush type to be provided at conference rooms. Floor devices must be 2 hour rated.

		
	 LIGHTING
	  	 Lighting Systems

•  Fixtures shall be suitable for the application including the ability to provide egress
illumination where required.
 •  Fixtures shall meet U.L. requirements and selection and placement
of fixtures shall comply with ADA requirements.
 •  All lighting fixtures shall operate at 277 V
unless specifically noted otherwise,
 •  Lighting Power Densities (LPD) must exceed with the Title
24 energy savings by 25% -35% to comply with LEED Silver Certification efforts.
 •  Office
and Lab areas to consist of direct/indirect linear pendant style fixtures or recessed direct/indirect light fixtures. Dimmable LED lighting to. be used to the maximum extent possible.

•  Exit Lights -Edge lit, Green on clear, 120/277, EL N.

 
 Lighting Control Systems

•  Lighting control must com ply with Title 24 requirements (including over-ride control for
automatically shutting the lights off at prescribed periods of time and the ability to override the lighting control for up to two hours of use).

•  Lighting control equipment shall include a programmable lighting control panel, relay panels
(quantity as necessary), over-ride switches (distributed throughout the space), and interconnecting conductors.

•  Control zones to include perimeter areas for daylit spaces, skylit areas, and interior areas
under5,0005F.
 •  Occupancy sensors will be provided for all offices less than 250 square feet and
conference rooms per Title 24 requirements. All other areas will be coordinated as to whether occupancy sensor or timeclock controlled shut-off will be provided.

  
 69 

			
		  	 •  Corridors will be provided with partial off (atleast50%) occupancy
sensors,
 •  Each room shall be controlled by dimming switching for local control.

•  Each private enclosed office to be provided with wall mounted dimmable switching and a ceiling
mounted motion sensor. Manufacturer: Wattstopper or equal.
 •  Photocells and dimming to be
installed per Title 24 requirements,
 •  Demand response capability will be
provided.

		
	 TELEPHONE/ DATA ROOM AND LOW VOLTAGE WIRING
	  	 Telephone/Data Room and Low Voltage Wiring

•  The shell MPOE room shall be used, and a conduit path to be provided to additional IDF rooms as
required. All telephone/data materials and installation are part of the tenant improvement allowance

		
	 AUXILIARY SYSTEMS
	  	Auxiliary Systems such as card readers, CCTV camera and AV are outside the scope of this project and will be installed separately as part of the Tenant’s effort. The Landlord must approve device appearance and
locations.

  
 70 

 EXHIBIT D TO LEASE 

ACKNOWLEDGMENT OF COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF COMMENCEMENT DATE is made this              day of
                    ,             , between ARE-SD REGION NO.
30, LLC, a Delaware limited liability company (“Landlord”), and XERIS PHARMACEUTICALS, INC. (“Tenant”), and is attached to and made a part of the Lease dated
                    ,              (the “Lease”), by and
between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

Landlord and Tenant hereby acknowledge and agree, for all purposes of the Lease, that the Commencement Date of the Base Term of the Lease is
                    ,             , and the termination date of the Base
Term of the Lease shall be midnight on                     ,
                    . In case of a conflict between the terms of the Lease and the terms of this Acknowledgment of Commencement Date, this
Acknowledgment of Commencement Date shall control for all purposes. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this
ACKNOWLEDGMENT OF COMMENCEMENT DATE to be effective on the date first above written. 
  

									
	TENANT:
	
	 XERIS PHARMACEUTICALS, INC.,

a Delaware corporation

		
	By:	 	  

	Its:	 	  

	
	LANDLORD:
	
	 ARE-SD REGION NO. 30, LLC,
 a
Delaware limited liability company

		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership,

managing member

			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
			
		 		 	By:                                   
                              
		 		 	Its:                                   
                               

  
 71 

 EXHIBIT E TO LEASE 

Rules and Regulations 

1. The sidewalk, entries, and driveways of the Project shall not be obstructed by Tenant, or any Tenant Party, or used by them for any purpose
other than ingress and egress to and from the Premises. 
 2. Tenant shall not place any objects, including antennas, outdoor furniture,
etc., in the parking areas, landscaped areas or other areas outside of its Premises, or on the roof of the Project. 
 3. Except for animals
assisting the disabled, no animals shall be allowed in the offices, halls, or corridors in the Project. 
 4. Tenant shall not disturb the
occupants of the Project or adjoining buildings by the use of any radio or musical instrument or by the making of loud or improper noises. 

5. If Tenant desires telegraphic, telephonic or other electric connections in the Premises, Landlord or its agent will direct the electrician
as to where and how the wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted. Any such installation or connection shall be made at Tenant’s expense. 

6. Tenant shall not install or operate any steam or gas engine or boiler, or other mechanical apparatus in the Premises, except as
specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is expressly prohibited. Explosives or other articles deemed extra hazardous shall not be brought into the Project. 

7. Parking any type of recreational vehicles is specifically prohibited on or about the Project. Except for the overnight parking of operative
vehicles, no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it shall be removed within 48 hours. There shall be no “For Sale” or other advertising signs on or about any parked
vehicle. All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All parking will be open parking, and no reserved parking, numbering or lettering of individual spaces will be permitted except as
specified by Landlord. 
 8. Tenant shall maintain the Premises free from rodents, insects and other pests. 

9. Landlord reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is intoxicated or under the
influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the Project. 
 10. Tenant
shall not cause any unnecessary labor by reason of Tenant’s carelessness or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring,
or for any damage done to the effects of Tenant by the janitors or any other employee or person. 
 11. Tenant shall give Landlord prompt
notice of any defects in the water, lawn sprinkler, sewage, gas pipes, electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 

  
 72 

 12. Tenant shall not permit storage outside the Premises by Tenant or any Tenant Parties,
including without limitation, outside storage of trucks and other vehicles, or dumping of waste or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises by Tenant or any Tenant
Parties. 
 13. All moveable trash receptacles provided by the trash disposal firm for the Premises must be kept in the trash enclosure
areas, if any, provided for that purpose. 
 14. No auction, public or private, will be permitted on the Premises or the Project 

15. No awnings shall be placed over the windows in the Premises except with the prior written consent of Landlord. 

16. The Premises shall not be used for lodging, sleeping or cooking or for any immoral or illegal purposes or for any purpose other than that
specified in the Lease. No gaming devices shall be operated in the Premises. 
 17. Tenant shall ascertain from Landlord the maximum amount
of electrical current which can safely be used in the Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use more than such safe capacity. Landlord’s
consent to the installation of electric equipment shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 

18. Tenant assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 

19. Tenant shall not install or operate on the Premises any machinery or mechanical devices of a nature not directly related to Tenant’s
ordinary use of the Premises and shall keep all such machinery free of vibration, noise and airwaves which may be transmitted beyond the Premises. 

  
 73 

 EXHIBIT F TO LEASE 

TENANT’S PERSONAL PROPERTY 

None. 

  
 74 

 EXHIBIT G TO LEASE 

MAINTENANCE OBLIGATIONS 

Multi-Tenant Maintenance Responsibilities 
 3985 Sorrento Valley
Blvd. 
 Xeris Pharmaceuticals 
  

									
	 Maintenance Responsibilities: Multi-Tenant, ARE-Managed
Utilities
	  	Xeris	 	  	ARE	 
	 Water-domestic
	  				  	✓		 
	 Water-irrigation
	  				  	✓		 
	 Gas -tenant premises
	  	✓		 	  			
	 Gas - common area
	  				  	✓		 
	 Electric-tenant premises
	  	✓		 	  			
	 Electric - common area
	  				  	✓		 
	 Exterior / Site
	  

	 Landscaping
	  				  	✓		 
	 Pest control - exterior
	  				  	✓		 
	 Parking lot sweeping
	  				  	✓		 
	 Project security (nightly rounds)
	  				  	✓		 
	 Parking lot lighting
	  				  	✓		 
	 Exterior monument and footpath lighting
	  				  	✓		 
	 Landscape irrigation
	  				  	✓		 
	 Exterior window washing
	  				  	✓		 
	 Roof inspections
	  				  	✓		 
	 Trash & recycling pickup
	  				  	✓		 
	 Domestic backflow preventer certification - Industrial / Domestic
	  				  	✓		 
	 Domestic backflow preventer certification - Fire
	  				  	✓		 
	 Building Interior and Central Plant
	  

	 Cold rooms
	  	✓		 	  			
	 Autoclaves
	  	✓		 	  			
	 Glassware washers
	  	✓		 	  			
	 RO/DI laboratory water systems
	  	✓		 	  			
	 Air compressors
	  	✓		 	  			
	 Vacuum pumps
	  	✓		 	  			
	 Laboratory gas distribution systems
	  	✓		 	  			
	 Emergency eyewash and shower stations
	  	✓		 	  			
	 Internal UPS units
	  	✓		 	  			
	 Fire extinguisher inspection / certification - tenant premises
	  	✓		 	  			
	 Fire extinguisher inspection / certification - common area
	  				  	✓		 
	 Fire sprinkler system
	  				  	✓		 
	 Fire alarm system (and phone lines)
	  				  	✓		 
	 Building HVAC equipment-tenant premises
	  	✓		 	  			
	 Building HVAC equipment - common area
	  				  	✓		 
	 Smoke fire dampers
	  	✓		 	  			
	 Security (burglar alarm) - tenant premises
	  	✓		 	  			
	 Access controls - tenant premises
	  	✓		 	  			
	 Access controls - common area
	  				  	✓		 
	 Janitorial - tenant premises
	  	✓		 	  			
	 Janitorial-common areas
	  				  	✓		 
	 l/R Testing of electrical systems
	  				  	✓		 
	 Emergency generator
	  				  	✓		 
	 Environmental monitoring
	  	✓		 	  			

  
 75 

 EXHIBIT H TO LEASE 

ASBESTOS DISCLOSURE 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain Information about asbestos within or about the Building in accordance with California Code of Regulations, title 8, section
1529 and Section 25915 et. seq. of the California Health and Safety Code. 
 Historically, asbestos was commonly used in building products used in the
construction of buildings across the country. Asbestos-containing building products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are
still sometimes found in buildings today. 
 The Building has undergone several rounds of improvement since its original construction in 1976. These
improvements included interior demolition and related ACM abatement down to concrete floors and studs according to former facility personnel. However, no documentation regarding the removal of ACMs is available and an asbestos survey has not been
performed. Considering the extensive improvements conducted, it’s unlikely that ACMs are present in the building. Nonetheless, due to the lack of abatement documentation, the present of ACMs or PACMs cannot be ruled out. 

Because ACMs and PACMs may be present within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and
maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful asbestos exposure to any person within or about the Building. The O&M Program includes a description of work
methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly
administer the O&M Program. 
 The O&M Program describes the risks associated with asbestos exposure and how to prevent such exposure through
appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or
(2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis
or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers, reduce the risks of adverse health effects. 

The O&M Program describes a number of activities that should be avoided in order to prevent a release of asbestos fibers. In particular, you should be
aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not qualified to handle ACMs. 

The O&M Program is available for review during regular business hours at the Landlord’s office located at 10996 Torreyana Road, Suite 250, San Diego,
CA 92121. 

  
 76EX-10.12

 Exhibit 10.12 

[***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN
FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 
 API
SUPPLY AGREEMENT 
 This API Supply Agreement (“Agreement”) is made as of the January I, 2018 (“Effective
Date”), by and between Xeris Pharmaceuticals, Inc., a Delaware Corporation, with a place of business at 180 N. LaSalle Street, Suite 1800, Chicago, Illinois 60601, USA (“XERIS”). and Bachem Americas, Inc., a California
Corporation, with a place of business at 3132 Kashiwa Street, Torrance, CA 90505, USA (“BACHEM”). XERIS and BACHEM may be referred to individually as a “Party” or collectively as the “Parties.” 

Background 
 XERIS
is engaged in the business of developing and commercializing pharmaceutical products; 
 BACHEM is engaged in the manufacture and
supply of active pharmaceutical ingredients for research and development purposes and commercial use; 
 XERIS desires to purchase
from BACHEM, and BACHEM desires to supply to XERIS, the active pharmaceutical ingredient or drug substance known as Glucagon (as further defined below, the “API”) for use by XERIS in manufacturing finished drug products
incorporating such active pharmaceutical ingredient, all in accordance with the terms and conditions of this Agreement. 
 NOW,
THEREFORE, in consideration of the mutual covenants and premises herein contained, the Parties hereto agree as follows: 

ARTICLE 1 

DEFINITIONS 
 1.1
“Affiliate” or “Affiliates” shall mean, with respect to a Party, any corporation, limited liability company or other business entity controlling, controlled by or under common control with such Party, for so long as
such relationship exists. For the purposes of this definition, control means: (a) to possess, directly or indirectly, the power to direct affirmatively the management and policies of such corporation, limited liability company or other business
entity, whether through ownership of voting securities or by contract relating to voting rights or corporate governance; or (b) ownership of more than fifty percent (50%) of the voting stock in such corporation, limited liability company or
other business entity (or such lesser percent as may be the maximum that may be owned pursuant to Applicable Laws of the country of incorporation or domicile, as applicable). 

1.2 “API” shall mean Glucagon, Pharma Grade Material, as currently defined under BACHEM product code [***] Specifications,
and as subsequently amended from time to time as required and as mutually agreed to between the Parties and attached to the Quality Agreement. 

1.3 “Applicable Laws” shall mean: (a) all relevant federal, state and local laws, statutes, rules, codes of practice,
regulations, and ordinances in the United States, Europe and any other countries, as mutually agreed upon in advance by the Parties, as well as industry standards and regulatory guidelines applicable to the manufacture and supply of API, including,

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

the United States Federal Food, Drug, and Cosmetic Act; (b) cGMPs; and (c) all applicable regulations and guidelines of any Regulatory Authority; in
each case, together, with any and all amendments thereto. 
 1.4 “cGMPs” shall mean current good manufacturing practices,
as provided for (and as amended from time to time) in: (a) the Current Good Manufacturing Practice regulations promulgated by the FDA under the United States Food, Drug arid Cosmetic Act; (b) the European Community Directive 91/356/EEC
(Principles and guidelines of good manufacturing practice for medicinal products), as well as applicable documents developed by the International Conference 6n Harmonization (ICH) Q7 Guideline: Good Manufacturing Practice Guide for Active
Pharmaceutical ingredients; (c) the Swissmedic Therapeutic Product Guidelines for authorization and supervision of therapeutic products; and (d) similar requirements of other Regulatory Authorities; subject to any arrangements, additions
or clarifications, and the respective roles and responsibilities, agreed from time to time between the Parties. 
 1.5 “Drug Master
File” or “DMF” shall mean a drug master file filed with the FDA or the EM A which includes confidential detailed information relating to the facilities, processes, or articles used in manufacturing, processing, packaging,
testing and storing of the API, or any equivalent filing in any jurisdiction outside the United States or Europe. 
 1.6
“EMA” shall mean the European Medicines Agency, or any successor entity thereto performing substantially similar functions. 

1.7 “Facility” shall mean BACHEM’s cGMP-compliant manufacturing facilities located at Hauptstrasse 144,4416 Bubendorf,
Switzerland 
 1.8 “FDA” shall mean the United States Food and Drug Administration, or any successor entity thereto
performing substantially similar functions. 
 1.9 “Latent Defect” shall mean, with respect to API, a hidden or latent
defect not detected by the analytical test methods in operation at the date of shipment to XERIS by BACHEM and which was not detected by XERIS during the inspection period defined in Section 4.3.1. 

1.10 “Major Change” shall mean a change that may adversely impact quality, safety, efficacy, stability, regulatory
compliance, or regulatory registration of the API or Product. 
 1.11 “Product” shall mean a finished pharmaceutical drug
product incorporating the API. 
 1.12 “Regulatory Authority” shall mean the FDA, EMA or any other governmental or
regulatory authority responsible for the regulation of API used in pharmaceutical products intended for human use in an applicable. 
 1.13
“Specifications” shall mean those specifications and release requirements, as defined in the current Quality Agreement. 

  
 2 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

1.14 “Quality Agreement” shall mean the Quality Assurance Agreement between the Parties dated November 20,2015, and as
amended on October 31, 2016 and January 26,2017, and as may be further amended from time to time, which contains the current Specifications and specifies the Parties’ respective responsibilities regarding the manufacture, storage,
release, quality control and quality assurance of API in accordance with requirements of Regulatory Authorities and cGMP’s. In the event that any conflict shall arise between the terms of this Agreement and the Quality Agreement, the terms of
this Agreement shall take precedence over the terms of the Quality Agreement in all respects except matters of quality and pharmacovigilance, in which case the Quality Agreement shall take precedence. 

1.15 “Warehouse” shall mean BACHEM’s cGMP-compliant warehousing facilities located at 3132 Kashiwa Street, Torrance,
California, USA. 
 ARTICLE 2 

SUPPLY 
 2.1 API
Supply. Subject to the terms and conditions of this Agreement, BACHEM shall supply to XERIS, such quantities of the API as may be specified in purchase orders submitted by XERIS pursuant to Section 2.3 below from time to time during
the Term. All API to be supplied under this Agreement shall be manufactured by BACHEM at the Facility, in conformance with Applicable Laws, the Specifications and the Quality Agreement. 

 

	 	2.2	Forecasts. 

 2.2.1 At the beginning of each [***] during the Term, XERIS shall provide
BACHEM with a [***] forecast of the gross weight quantities of the API estimated to be required (each, a “Rolling Forecast”). The Rolling Forecast from the beginning of the first [***] in any given year shall be the calendar year
forecast (each, a “Calendar Year Forecast”). Subject to provisions in Sections 2.3 and, the first [***] of such Rolling Forecasts and Calendar Year Forecasts shall be binding and all remaining quarters of such forecasts
are non-binding and serve only to facilitate BACHEM’s production scheduling. BACHEM shall inform XERIS within [***] of receiving a Rolling Forecast, in writing by email, if such forecast cannot be met or
is at risk of not being met due to capacity or shelf-life constraints as defined herein. Failure of BACHEM to accept or reject a forecast within [***] of receipt shall be deemed an acceptance of the Rolling Forecast and confirmation of suitable
available capacity. 
 2.2.2 At the beginning of each [***] during the Term, BACHEM shall provide an estimate of their total production
capacity available for XERIS API, above and beyond the requirements of the Rolling Forecast if any, (“Toted Capacity Constraints”) for the next [***] period. 

2.3 Orders. 
 2.3.1
Orders. Together with each Rolling Forecast provided under Section 2.2 above, XERIS shall place a firm order for the applicable calendar quarter or multiple smaller orders throughout the applicable calendar quarter with BACHEM for
the gross weight quantity of API required for delivery. For each calendar year of this Agreement, XERIS shall use commercially reasonable efforts to order a gross weight quantity of API for delivery at least

  
 3 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

equal to the gross weight quantity of API contained in the applicable Calendar Year Forecast. For the avoidance of doubt, XERIS may order quantities of API in
addition to those specified in the then current Calendar Year Forecast and Rolling Forecast for delivery hereunder in accordance with the lead times therefor and subject to BACHEM’s Purchase Order acceptance and Total Capacity Constraints.
Unless otherwise limited by BACHEM’s Total Capacity Constraints, BACHEM agrees to provide up to [***] of any forecast if ordered by XERIS, unless Parties agree to a higher quantity in writing. BACHEM shall use commercially reasonable efforts to
accept and fulfill all orders for API provided by XERIS under this Agreement and endeavor to hold stock sufficient to meet the next [***] of each Rolling Forecast. 

2.3.2 Form of Orders. XERIS’s orders shall be made pursuant to a written purchase order (each, a “Purchase
Order”) that specifies, at a minimum, quantity of API ordered, date of order, date of delivery, addresses for delivery, contact information at delivery sites, and required carriers with account numbers, one of which must be utilized for
delivery to the specified destinations. BACHEM shall use commercially reasonable efforts to achieve a maximum lead time of no more than [***] to complete and deliver an order. BACHEM shall accept all orders XERIS submits to BACHEM in accordance with
this Article 2. BACHEM shall provide to XERIS written notice of BACHEM’s acceptance (each, an “Acceptance Notice” of each Purchase Order within [***] of BACHEM’s receipt of such Purchase Order and each such
Acceptance Notice shall include confirmation of the delivery date of the applicable quantity of API; provided that to the extent no delivery date is included in an Acceptance Notice issued by BACHEM or BACHEM fails to issue an Acceptance Notice
within the applicable time period, the order shall be deemed accepted by BACHEM and the applicable delivery date shall be deemed to be the delivery date specified by XERIS in the corresponding Purchase Order. Except as to the quantity of API,
delivery date and delivery location specified in a Purchase Order which shall be binding on the Parties, NO TERMS OR CONDITIONS CONTAINED IN ANY PURCHASE ORDER, ORDER ACKNOWLEDGMENT OR SIMILAR STANDARDIZED FORM SHALL BE CONSTRUED TO AMEND OR MODIFY
THE TERMS OF THIS AGREEMENT, AND ALL SUCH TERMS AND CONDITIONS ARE HEREBY EXCLUDED. 
 2.3.3 Retest Date. API supplied by BACHEM
under this Agreement shall have a retest date that is at least [***]%) of the original re-test date at the time of delivery of such API to XERIS, unless otherwise agreed to by XERIS in writing in advance of
the delivery. If BACHEM cannot supply API with the required re-test Date, XERIS shall have the [***]. If XERIS agrees in writing to accept API with a [***] and if requested by XERIS, BACHEM agrees to re-test any such API and extend the retest date to a minimum of [***] within cGMP, ICH and DMF guidelines and complete such testing prior to shipment. 

2.4 Shipping and Warehousing. BACHEM shall deliver quantities of API ordered by XERIS in accordance with Section 2.3
above, to the locations specified in the applicable Purchase Order. Shipments may be shipped DDP (Incoterms 2010) direct to XERIS locations specified on a Purchase Order, or, FCA (Incoterms 2010) to
BACHEM’s Warehouse in Torrance, CA USA. While in-transit and during storage at the Warehouse, BACHEM shall ensure API is shipped and stored according to cGMP’s and Specifications. BACHEM shall
request advance import and customs information from XERIS as required and ship API, together with all relevant documentation relating to the API, including, but not limited to those documents listed in Exhibit 2, in accordance with any agreed-upon
shipment specifications or as 

  
 4 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

otherwise reasonably directed by XERIS in writing and in accordance with this Agreement. XERIS shall only be obligated to pay for quantities of API actually
delivered in compliance with the applicable Purchase Order and the terms of this Agreement. 
 2.5 Shortage of Supply. If BACHEM is
unable, or anticipates that it will not be able, to supply XERIS’s requirements for the API in accordance with Sections 2.2 and 2.3 above fa “Shortage of Supply”). BACHEM shall notify XERIS in writing of the same
within [***] of receipt of applicable Purchase Orders, Rolling Forecast or determination that a Shortage of Supply will exist, and shall include in such notice its best estimate of the duration of the delay, the reasons for the delay, and whether
the reason impacts the validated state of the process. BACHEM shall, at its own cost, use commercially reasonable efforts to remedy any Shortage of Supply and resume supplying API meeting the requirements of this Agreement to XERIS as soon as
possible. In addition to the foregoing measures, if BACHEM is unable to supply XERIS’s requirements of API, BACHEM shall allocate the quantities of the API that BACHEM has in inventory, and that BACHEM is able to produce, on a reasonable
worldwide basis (based upon sales history and realistic forecasted demand). In the event of a Shortage of Supply exceeding [***] ([***]%), in addition to any other rights or remedies that XERIS may have under this Agreement, or at law or in equity,
XERIS shall be relieved from its obligations to purchase any quantities of API identified in any outstanding Purchase Order, Calendar Year Forecast or Rolling Forecast. 

ARTICLE 3 
 PAYMENTS

 3.1 Price. The Price for the API subject to this Agreement shall be based on annual calendar year volume as listed in the
schedule in Exhibit 1. 
 3.2 Mid-year Price Adjustment. XERIS shall notify BACHEM as soon as
reasonably possible, in writing by email, if it does not intend to order the total gross weight quantity of API contained in a Calendar Year Forecast; and to the extent the lower annual quantity would affect Price, XERIS shall pay [***]. XERIS shall
notify BACHEM as soon as reasonably possible, in writing by email, if it intends to order a total gross weight quantity of API greater than contained in a Calendar Year Forecast; and subject to BACHEM accepting the additional order quantities as
provided for in Section 2.3.1 and to the extent the higher annual quantity would affect Price, BACHEM shall [***]. 
 3.3
Invoicing: Payment. BACHEM shall submit an invoice to XERIS upon shipment of API ordered by XERIS hereunder. All invoices shall be sent to the address specified in the Purchase Order therefor, and each invoice shall state the Price for the
gross weight quantity of API in a given shipment, plus any documented taxes and other costs incident to the purchase or shipment initially paid by BACHEM but to be borne by XERIS hereunder. All payments shall be made by direct bank transfer to an
account designated in BACHEM’s invoice. In connection with an order, XERIS may provide BACHEM with a reseller certificate, in which case, XERIS will be exempt from all relevant sales taxes. Payments shall be due [***] from invoice date. Payment
by XERIS shall not constitute acceptance of any shipment of API or impair XERIS’s right of inspection and rejection under Article 4 below. 

  
 5 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

ARTICLE 4 
 QUALITY

 4.1 Quality Assurance. All API supplied by BACHEM shall meet the agreed current Specifications and shall be manufactured and
stored in accordance with all Applicable Laws relevant to the Facility, Warehouse and the Quality Agreement. BACHEM agrees that, prior to each shipment of API hereunder, it shall perform quality assurance and quality control procedures reasonably
necessary to ensure that the API to be shipped conforms fully with the Specifications and in compliance with cGMP’s. Each shipment of API shall be accompanied by a certificate of analysis, which will include a signed certification of cGMP
compliance and such additional documents as may be specified in the Quality Agreement or as otherwise reasonably required by XERIS from time to time. 

4.2 Quality Agreement. Prior to XERIS issuing its first Purchase Order to BACHEM pursuant to this Agreement, the Parties shall review
and may update the existing Quality Agreement as agreed to in writing, if required. 
 4.3 Rejection and Replacement of API. 

4.3.1 Inspection by XERIS. XERIS, or its designee, shall have [***] following its receipt of a shipment of API to reject such API on the
grounds that all or part of the shipment fails to conform to the applicable Specifications or otherwise fails to conform to the warranties given by BACHEM in Section 9.2, which rejection shall be accomplished by giving written notice to
BACHEM summarizing the manner in which all or part of such shipment fails to meet the foregoing requirements. The foregoing inspection obligation will not prevent XERIS from enforcing any rights under this Agreement if Latent Defects in the API are
discovered after the [***] inspection period as set forth herein, so long as XERIS informs BACHEM in writing immediately, but no later than [***] after its discovery and within the original retest date for any API delivered. XERIS shall be
responsible for storage and handling the API in accordance with the Specifications upon delivery. 
 4.3.2 Resolution of Disputes.
BACHEM shall acknowledge receipt in writing to a rejection notice from XERIS within [***] from the date of receipt of such rejection notice in accordance with Section 4.3.1 above. If BACHEM does not agree with XERIS’s determination
that such API fails to conform to the Specifications or the warranties provided by BACHEM in Section 9.2, then BACHEM and XERIS shall use reasonable efforts to resolve such disagreement as promptly as possible. Without limiting the
foregoing, either party may submit the API to a nationally recognized testing laboratory (the “Laboratory”) which shall be agreed upon by the parties in advance, to test whether or not the API conforms to the Specifications or the
warranties provided by BACHEM in Section 9.2. The Laboratory’s determination will be final. If the Laboratory determines that the API does not conform to the Specifications or the warranties provided by BACHEM in
Section 9.2, BACHEM will be responsible for all expenses related to the Laboratory testing, otherwise XERIS will be responsible for those expenses. 

4.3.3 Replacement of API. API accepted by BACHEM as not meeting the applicable requirements or the Specifications, or which is
determined by the Laboratory not to meet such requirements or the Specifications, shall be returned by XERIS to BACHEM, or 

  
 6 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

disposed of, as directed by BACHEM, at BACHEM’s expense. BACHEM shall replace all such rejected API within the shortest possible time, but in any event,
within a reasonable timeframe, as agreed to by the Parties, after its receipt of notice of such rejection (or, if applicable, the Laboratory’s determination that such API was non-conforming). Without
limiting any other provision in this Agreement, XERIS may withhold payment for such shipment or the portion thereof that has been rejected by XERIS, or, if Parties cannot agree on a suitable timeframe to replace such rejected API, XERIS shall be
entitled to a full refund of prior payments for such shipment or the portion thereof that has been rejected by XERIS, pursuant to this Section 4.3. The warranties given by BACHEM in Section 9.2 below shall survive any failure
to reject by XERIS under this Section 4.3. 
 4.4 Changes. 

4.4.1 BACHEM shall maintain change control systems that ensure that XERIS is notified in a timely manner regarding all Major Changes as agreed
to by the Parties in accordance with the Quality Agreement. 
 4.4.2 BACHEM shall promptly inform XERIS in writing of any proposed Major
Change to the raw materials, intermediates, manufacturing process, equipment, packaging, labeling, testing, specifications, storage or shipping, if such item is specifically mentioned in the DMF. Notwithstanding the foregoing, in no event will
BACHEM implement any Major Change with respect to quantities of API to be supplied to XERIS, without giving XERIS prior written notice, and prior to all necessary filings with and approvals by applicable Regulatory Authorities have been made or
obtained by B ACHEM or XERIS, as applicable. 
 ARTICLE 5 

RECORDS: INSPECTIONS 
 5.1
Record Keeping. BACHEM shall generate and maintain complete and accurate records in the language of the Facility and Warehouse as required by the GMP guidelines and samples as necessary to evidence compliance with this Agreement and all
Applicable Laws and other requirements of applicable governmental authorities relating to the raw materials, intermediates, manufacturing process, packaging, labeling, testing, specifications, storage or shipping activities relating to the API. All
such records and samples shall be maintained by BACHEM in accordance with the procedures set out in the Quality Agreement for the applicable time period specified therein. 

5.2 Inspection. During the term of this Agreement, and for [***] thereafter, or as otherwise required by Applicable Laws, XERIS (or an
agreed upon designee) shall have the right to inspect and audit, during regular business hours: (a) any facility at which any of the raw material receiving, manufacturing or processing, packaging, labeling, testing, storage or shipping
activities relating to the API are performed, including the Facility and Warehouse, with the exception of some analytical testing, which may be sub-contracted out to other facilities; and (b) any of
BACHEM’s manufacturing and quality control records and all other documentation relating to the manufacturing and processing activities with respect to the API (including any internal quality assurance/control audits or reviews conducted by
BACHEM), with the understanding that executed manufacturing batch records may only be reviewed onsite. During 

  
 7 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

any such audit, BACHEM shall use reasonable efforts to provide an oral or written translation and explanation of original documents of critical portions of
any manufacturing or quality control record to XERIS as may be reasonably requested by XERIS, in accordance with the Quality Agreement. Such inspections and audits shall be conducted annually and with reasonable notice in accordance with any
procedures for audits specified in the Quality Agreement; provided however that XERIS shall have the right to conduct additional inspections and audits under this Section 5.2 if there has been a replacement of API under
Section 4.3.3 or any other cause-related dispute related hereto. 
 ARTICLE 6 

REGULATORY MATTERS 
 6.1
Regulatory Actions. BACHEM shall permit the FDA and other Regulatory Authorities, as applicable, to conduct such inspections of the Facility, and any other facility at which any of the raw material receiving, manufacturing or processing,
packaging, labeling, testing, storage or shipping activities relating to the API are performed, with the exception of some analytical testing which may be sub-contracted out to other facilities, as such
Regulatory Authorities may request, including pre-approval inspections, and shall cooperate with such Regulatory Authorities with respect to such inspections and any related matters, in each case that is
related to the manufacture and supply of API. BACHEM shall notify XERIS about such regulatory actions or inspections as further described, and in accordance with the Quality Agreement. 

6.2 Regulatory Cooperation. BACHEM has registered the API with the FDA as a Generic product and, during the Term, BACHEM will timely
perform all necessary filings and pay all required fees to maintain the Generic status. BACHEM agrees to provide to XERIS or directly to the applicable Regulatory Authority, as requested by such Regulatory Authority, with all reasonable information
and data in BACHEM’s possession or control reasonably necessary for XERIS (or its designees) to apply for, obtain and maintain regulatory approvals for any Product in the United States, Europe and any other countries, as mutually agreed upon in
advance by the Parties. In addition, BACHEM agrees to reasonably cooperate with XERIS (or its designees) with respect to obligations to submit or report information relevant to API pursuant to FDA and other Regulatory Authorities or to comply with
Applicable Laws relevant to the Facility and the Warehouse. 
 6.3 Drug Master Files. BACHEM shall provide, or cooperate with XERIS
to provide, the appropriate authorizations to each applicable Regulatory Authority allowing XERIS (or its designee) the right to reference all Drug Master Files to support any mutually agreed to regulatory filing for any Product developed,
manufactured or commercialized by XERIS, its Affiliates and licensees. If the Drug Master File filed with the FDA or applicable Regulatory Authority(ies) as of the Effective Date is not sufficient to support the applicable regulatory filing for a
Product, Parties agree to use commercially reasonable efforts to develop a corrective action plan agreeable to both Parties, and BACHEM shall use commercially reasonable efforts to correct any deficiencies of such Drug Master File(s) identified by
any Regulatory Authority in a prompt and efficient manner so as to prevent any delay in XERIS (or any of its Affiliates or licensees) obtaining regulatory approval for a Product based on such Drug Master File(s). In addition, BACHEM shall be
responsible for maintaining such Drug Master File(s) in accordance 

  
 8 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

with Applicable Laws relevant to the Facility and ensuring that all data and information incorporated therein is accurate and current as necessary to support
obtaining and maintaining the applicable regulatory filings) and regulatory approval(s) by XERIS (or its designees). 
 6.4 Recall.
Any recalls of any of XERIS’s Products shall, as between the Parties, be controlled solely by XERIS; provided, however, that if BACHEM reasonably believes a recall may be necessary with respect to any API provided under this Agreement, BACHEM
shall immediately notify XERIS in writing. BACHEM shall provide assistance to XERIS (or its designee), as reasonably requested, in conducting such recall, including providing all pertinent records as may be required by Regulatory Authorities in the
region affected, to assist XERIS in effecting such recall. Except as otherwise provided for under Article 10, BACHEM shall reimburse XERIS for reasonable and documented recall expenses directly related to an API quality defect proven by XERIS
to have been solely caused by BACHEM’s negligence or error and which, in no event, shall exceed $[***], and BACHEM shall also reimburse XERIS for the cost of the API used to manufacture Product involved in the recall. 

ARTICLE 7 
 TERM AND
TERMINATION 
 7.1 Term. The term of this Agreement shall commence on the Effective Date and shall continue for an initial term
of [***] (“Initial Term”), Thereafter, this Agreement shall automatically be renewed for successive [***] periods (each, a “Renewal Term;” and all such Renewal Terms together with the Initial Term, collectively, the
“Term”‘), unless either Party notifies the other Party in writing at least [***] prior to the expiration of the then-current Term that such Party does not wish to renew this Agreement for an additional Renewal Term. 

7.2 Termination for Material Breach. If either Party materially breaches this Agreement or the Quality Agreement at any time, the non-breaching Party shall have the right to terminate this Agreement by written notice to the breaching Party, if such breach is not cured within [***] days after written notice is given by the non-breaching Party to the breaching Party specifying the breach. 
 7.3 Termination for Failure to
Supply. Without limiting any other provision of this Agreement, including Sections 2.5 and 7.2 above, if [***] (a) Late Shipments of API or (b) Shortages of Supply of API occur during any [***] period, then XERIS shall have the right to
terminate this Agreement immediately by written notice to BACHEM. For purposes of this Section 7.3, a Late Shipment shall mean any shipment of a BACHEM confirmed Purchase Order that is delivered more than [***] days past the delivery date
specified in the applicable Purchase Order (each a “Late Shipment”) 
 7.4 Termination by XERIS. XERIS may terminate
this Agreement immediately upon written notice to BACHEM if: (a) XERIS, in its sole discretion, determines that Products will not be marketed by XERIS (or its designee); or (b) the FDA or EMA withdraws approval of, or fails to approve, the
manufacturing or marketing by XERIS (or its designee) of all Products then in development. 
 7.5 Effects of Termination. It is
understood that termination or expiration of this Agreement shall not relieve a Party from any liability that, at the time of such termination or 

  
 9 

 [***] INDICATES MATERIAL THAT HAS BEEN OMITTED AND FOR WHICH CONFIDENTIAL TREATMENT HAS BEEN
REQUESTED. ALL SUCH OMITTED MATERIAL HAS BEEN FILED WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 406 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED 

expiration, has already accrued to the other Party, except as specified in this Section 7.5. Upon expiration or termination of this Agreement for
any reason (other than by XERIS pursuant to Section 7.2 or 7.3 above), to the extent BACHEM so notifies XERIS, XERIS shall have the obligation to purchase all API ordered under any outstanding Purchase Orders and will pay the
applicable price differential for the lower annual volume, if any, for the volume of API ordered and delivered to XERIS year-to-date. To the extent XERIS notifies BACHEM
of expiration or termination of this Agreement according to provisions provided herein, XERIS shall have the option to purchase additional transitional stock of API from BACHEM, in addition to quantities contained in outstanding Purchase Orders, of
less than or equal to [***]([***])% of the most recent Rolling Forecast at the applicable price and according to a delivery schedule mutually agreeable to both Parties. 

7.6 Survival. The provisions of Sections
1,2.4,3-6,7.5,7.6,8-11 shall survive the expiration or termination of this Agreement for any reason. In addition, the provisions of the Quality Agreement shall survive
expiration or termination of this Agreement until the date of expiration of the last-to-expire batch of API delivered by BACHEM to XERIS hereunder. All other Tights and
obligations of the Parties shall cease upon termination of this Agreement. Except as otherwise expressly provided in this Section 7.6, all other rights and obligations of the Parties shall terminate. 

ARTICLE 8 

CONFIDENTIALITY 
 8.1
Confidential Information. Except as otherwise provided in this Article 8, during the Term and for a period of [***] years thereafter, each Party shall maintain in confidence and only use for the purposes of this Agreement any
confidential information, data and materials supplied to such Party by the other Party (“Confidential Information”) A receiving Party’s obligations under this Article 8 shall not apply to any information, data or
material that, in each case as demonstrated by written documentation: (a) was already known to the receiving Party, other than under an obligation of confidentiality, at the time of disclosure; (b) was generally available to the public or
otherwise part of the public domain at the time of its disclosure to the receiving Party; (c) became generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of the
receiving Party in breach of this Agreement; (d) was subsequently lawfully disclosed to the receiving Party by a person other than the disclosing Party; or (e) was independently developed by the receiving Party without reference to any
Confidential Information of the disclosing Party. 
 8.2 Confidentiality:
Non-Disclosure. Each Party agrees not to disclose any Confidential Information of the other Party except to those employees and consultants who have a need to know and provided that each person to whom
Confidential Information is disclosed agrees to be bound by the same terms regarding the disclosure and use of Confidential Information as set forth in this Article 8. Each Party further agrees not to use or disclose the Confidential
Information of the other Party except as otherwise permitted by this Agreement, or as may be necessary to exercise its rights or perform its obligations under this Agreement. Nothing contained in this Article 8 shall prevent either Party from
disclosing any Confidential Information of the other Party to: (a) regulatory agencies for the purpose of obtaining approval to distribute and market Products; provided, however, that all reasonable steps are taken to

  
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maintain the confidentiality of such Confidential Information to be disclosed; (b) to accountants, lawyers or other professional advisors or in
connection with a merger, acquisition, securities offering or other strategic transaction, subject in each case, to the recipient entering into an agreement to protect such Confidential Information from disclosure; or (c) is required by law or
regulation to be disclosed; provided, however, that the Party subject to such disclosure requirement has provided written notice to the other Party promptly upon receiving notice of such requirement in order to enable the other Party to seek a
protective order or otherwise prevent disclosure of such Confidential Information. 
 ARTICLE 9 

REPRESENTATIONS AND WARRANTIES 

9.1 Mutual Warranties. Each Party represents and warrants to the other Party that: (a) it has the power and authority to enter
into this Agreement and to perform its obligations hereunder and to grant to the other Party the rights granted to such other Party under this Agreement; (b) it has obtained all necessary corporate approvals to enter into and execute this
Agreement and to perform its obligations hereunder; and (c) the execution, delivery and performance of this Agreement does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it may
be bound, nor will it enter into or assume during the Term, any contract or other obligation with a third party that would in any way limit the performance of its obligations under this Agreement. 

9.2 BACHEM Warranties. BACHEM represents and warrants that: 

9.2.1.1 API. All API supplied hereunder shall (a) comply with all Applicable Laws and the Quality Agreement and
meet all Specifications and cGMP’s, and (b) BACHEM shall perform and document all manufacturing and supply activities contemplated herein in compliance with all Applicable Laws. 

9.2.1.2 Facilities and Equipment. The Facility, all equipment used for the manufacture of API within the Facility and
the activities contemplated herein, and any other facility at which any of the manufacturing or processing, packaging, labeling, testing or storage activities relating to the API are performed will comply with all Applicable Laws and cGMP’s,
and BACHEM shall obtain and maintain all governmental registrations, permits, licenses and approvals necessary for BACHEM to manufacture and supply API to XERIS, and otherwise to perform its obligations, under this Agreement 

9.2.1.3 No Encumbrance. Title to all API provided to XERIS under this Agreement shall pass as provided in this
Agreement, free and clear of any security interest, lien, or other encumbrance. 
 9.2.1.4 Personnel. Neither BACHEM,
nor any of its Affiliates, nor, to the best of BACHEM’s knowledge, any of their respective employees have been “debarred” by the FDA, or subject to a similar sanction from any Regulatory Authority in any jurisdiction outside the
United States, nor have debarment proceedings against BACHEM, any of its Affiliates, or any of their respective employees been commenced. BACHEM will promptly notify XERIS in Writing if any such proceedings have commenced or if BACHEM, any of its
Affiliates, or any of their respective employees are debarred by the FDA or any other Regulatory Authority. 

  
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9.3 XERIS Warranties. XERIS represents and warrants that it shall comply in all materials respects with all Applicable Laws pertaining
to the distribution, sale, and marketing of Product. 
 9.4 DISCLAIMER. EXCEPT AS PROVIDED IN THIS ARTICLE 9, NEITHER PARTY
MAKES ANY REPRESENTATIONS OR WARRANTIES (EXPRESS, IMPLIED, STATUTORY OR OTHERWISE) WITH RESPECT TO THE SUBJECT MATTER HEREOF AND EACH PARTY EXPRESSLY DISCLAIMS ANY SUCH ADDITIONAL REPRESENTATIONS AND WARRANTIES, INCLUDING ANY IMPLIED WARRANTIES OF
FITNESS FOR A PARTICULAR PURPOSE, MERCHANTABILITY OR NON-INFRINGEMENT OF THIRD PARTY INTELLECTUAL PROPERTY RIGHTS. 

ARTICLE 10 

INDEMNIFICATION AND LIMITATION OF LIABILITY 

10.1 XERIS. it is understood that BACHEM has no control over the ultimate use of the API or Products. XERIS shall indemnify, defend and
hold harmless BACHEM, its directors, officers, employees, agents, successors and assigns from and against any liabilities, expenses or costs (including reasonable attorneys’ fees and court costs) arising out of or relating to XERIS’ (a)
use of the API, other than as set forth herein, (b) use, sale, manufacturing, distribution or other disposal of the Products, (c) breach of its representations and warranties herein, Or (d) gross negligence or willful misconduct. 

10.2 BACHEM. BACHEM shall indemnify, defend and hold harmless XERIS, its directors, officers, employees, agents, successors and assigns
from and against all liabilities, expenses, and costs (including reasonable attorneys’ fees and court costs) arising out of or relating to BACHEM’s (a) breach of its representations and warranties herein and XERIS’ use of the
API, as set forth herein, (b) gross negligence or willful misconduct, or (c) subject to Section 6.4, API defects that result in a Product recall up to a maximum amount. 

10.3 Indemnification Procedure. Any Party seeking indemnification under this Article 10 (the “Indemnitee”) shall:
(a) promptly notify the Indemnifying Party (the “Indemnitor”) of such claim; (b) provide the Indemnitor sole control over the defense and settlement thereof; and (c) at the Indemnitor’s request and expense,
provide full information and reasonable assistance to Indemnitor with respect to such claims. Without limiting the foregoing, with respect to claims brought under Section 10.1 or 10.2 above, the Indemnitee, at its own expense,
shall have the right to participate with counsel of its own choosing in the defense and settlement of any such claim. The indemnification under this Article 10 shall not apply to amounts paid in settlement of any claim if such settlement is
effected without the consent of the Indemnitor. 
 10.4 Insurance. During the Term and for a period of [***] thereafter, BACHEM shall
maintain, with financially sound and reputable insurers, insurance reasonably sufficient to cover BACHEM’s activities and obligations under this Agreement. Without limiting the foregoing, BACHEM shall maintain, at its sole cost and expense
(i) general liability insurance (ii) 

  
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contractual liability insurance and (iii) product liability insurance, such insurances covering at least bodily injury, death, and property damage
limits, in such amounts and with such scope of coverage as is consistent with pharmaceutical industry standards to insure BACHEM’s indemnification and other obligations hereunder. At the reasonable request of XERIS, BACHEM shall provide to
XERIS copies of certificates of insurance evidencing coverage in accordance with this Section 10.4. 
 10.5 LIMITATION OF
LIABILITY. EXCEPT FOR A PARTY’S INDEMNIFICATION OBLIGATIONS, GROSS NEGLIGENCE OR WILLFUL MISCONDUCT, EACH PARTY’S LIABILITY SHALL BE LIMITED AS SET FORTH HEREIN AND IN NO EVENT SHALL EITHER PARTY BE LIABLE FOR (I) ANY SPECIAL,
INCIDENTAL, INDIRECT, PUNITIVE, CONSEQUENTIAL OR EXEMPLARY OR PUNITIVE DAMAGES; INCLUDING LOST PROFITS, OR OPPORTUNITY OR GOODWILL, HOWEVER CAUSED, UNDER ANY THEORY OF LIABILITY AND EVEN IF SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH
DAMAGES, OR (II) FOR EACH EVENT GIVING RISE TO ANY INJURIES, CLAIMS, LOSSES, EXPENSES, OR DAMAGES, AN AMOUNT EXCEEDING $[***]. To the extent that this clause conflicts with any other clause of this Agreement, this clause shall take precedence
over such conflicting clause. If applicable law prevents enforcement of this Section 10.5, then this Section shall be deemed modified to provide the maximum protection to each Party as is allowable under applicable law. 

ARTICLE 11 
 GENERAL
PROVISIONS 
 11.1 Assignment. The Parties agree that their rights and obligations under this Agreement may not be assigned or
otherwise transferred to a third party without the prior written consent of the other Party hereto. Notwithstanding the foregoing, either Party may transfer or assign its rights and Obligations under this Agreement to a successor to all or
substantially all of its business or assets relating to this Agreement whether by sale, merger, operation of law or otherwise; provided that such assignee or transferee has agreed to be bound by the terms and conditions of this Agreement. Subject to
the foregoing, this Agreement shall be binding upon and inure to the benefit of the Parties hereto, their successors and assigns. 
 11.2
Governing Law. This Agreement shall be governed by, and construed and interpreted in accordance with, the laws of the State of New York, as if entered into by New York residents and executed and wholly performed within the State of New York.

 11.3 Disputes. Except for any disputes with respect to non-conforming API, which shall be
resolved in accordance with Section 4.3 above, if BACHEM and XERIS are unable to resolve any dispute between them, either BACHEM or XERIS may, by written notice to the other, have such dispute referred to the senior management of BACHEM
and XERIS for attempted resolution by good faith negotiations within [***] after such notice is received. If the Parties are unable to resolve such dispute in accordance with the aforementioned procedure or within such [***] period, subject to
Section 11.4 below, either Party shall have the right to pursue any and all other remedies available to such Party. 

  
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11.4 Arbitration. Except for any disputes with respect to non-conforming API, which shall be
resolved in accordance with Section 4.3 above, any dispute or claim arising out of or in connection with this Agreement or the performance, breach or termination thereof which is unable to be resolved pursuant to discussions between the
Parties in accordance with Section 11.3 above, shall, upon notice by either Party to the other, be submitted to binding arbitration in New York City, New York under the Rules of the American Arbitration Association (or any successor
entity thereto, collectively, “AAA”) by one arbitrator appointed in accordance with said rules. The arbitrator may engage an independent expert with experience in the subject matter of the dispute to advise the arbitrator. The
decision and award rendered by the arbitrator shall be written, final and non-appealable and may be entered in any court of competent jurisdiction. The Parties agree that, any provision of applicable law
notwithstanding, they will not request, and the arbitrator shall have no authority to award, punitive or exemplary damages against any Party. The costs of any arbitration, including administrative fees and fees of the arbitrator, shall be shared
equally by the Parties, unless otherwise determined by the arbitrator. Each Party shall bear the cost of its own attorneys’ and expert fees. Notwithstanding the foregoing, either Party may apply to any court of competent jurisdiction for
injunctive relief without breach of this arbitration provision. 
 11.5 Notices. Any notice or report required or permitted to be
given or made under this Agreement by either Party shall be in writing and in English and delivered to the other Party at its address indicated below (or to such other address as a Party may specify by like notice) by courier or by registered or
certified airmail, postage prepaid, or by facsimile; provided, however, that all facsimile notices shall be promptly confirmed, in writing, by courier or by registered or certified airmail, postage prepaid. All notices shall be effective as of the
date received by the addressee. 
  

			
	 If to XERIS:
	  	Xeris Pharmaceuticals, Inc.
		  	180 N. LaSalle Street, Suite 1800
		  	Chicago, IL 60601
		
		  	Attn: Paul Edick, CEO
		
	 If to BACHEM:
	  	Bachem Americas, Inc.
		  	3132 Kashiwa Street
		  	Torrance, CA 90505
		
		  	Attn: Brian Gregg, COO

 11.6 Force Majeure. Neither Party will be liable for its failure to perforin any of its obligations
hereunder during any period in which such performance is delayed by acts of God, fire, war, embargo, riots, or other similar cause outside the reasonable control of such Party (“Force Majeure Event”). A Party affected by a Force
Majeure Event will promptly notify the other Party, explaining the nature and expected duration thereof and such Parry shall use all reasonable efforts to remedy or mitigate such Force Majeure Event and the effects thereof. Notwithstanding the
foregoing, if a Party is unable to perform any of its obligations under this Agreement for a period of more than [***] as a result of a Force Majeure Event, the other Party may terminate this Agreement upon written notice to the affected Party. 

  
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11.7 Interpretation. The headings to the several Articles and Sections of this Agreement are not a part of this Agreement, but are
included for convenience of reference only and shall not affect its meaning or interpretation. 
 11.8 Waiver. Any waiver of the
terms and conditions hereof must be explicitly in writing and executed by a duly authorized officer of the Party waiving compliance. The waiver by either of the Parties of any breach of any provision hereof by the other shall not be construed to be
a waiver of any succeeding breach of such provision or a waiver of the provision itself. The delay or failure of any Party at any time to require performance of any provision of this Agreement shall in no manner affect such Party’s rights at a
later time to enforce the same. 
 11.9 Severability. Should any section, or portion thereof, of this Agreement be held invalid or
unenforceable in any jurisdiction by any court of competent authority or by a legally enforceable directive of any governmental body, such section or portion thereof shall be validly reformed so as to approximate the intent of the Parties as nearly
as possible and, if unreformable, shall be deemed divisible and deleted with respect to such jurisdiction, but the Agreement shall not otherwise be affected. 

11.10 Independent Contractors. The relationship of XERIS and BACHEM established by this Agreement is that of independent contractors.
Nothing in this Agreement shall be construed to create a partnership, joint venture, agency or other fiduciary relationship between XERIS and BACHEM. Neither Party shall have any right, power or authority to assume, create or incur any expense,
liability or obligation, express or implied, on behalf of the other. 
 11.11 Entire Agreement: Amendment. The terms and
provisions contained in the Agreement (including the Exhibits hereto and any Purchase Orders issued pursuant hereto) and the Quality Agreement constitute the entire agreement between the Parties and Shall supersede all previous communications,
representations, agreements or understandings, either oral or written, between the Parties with respect to the subject matter hereof. No agreement or understanding varying or extending this Agreement shall be binding upon either Party hereto, unless
set forth in a writing which specifically refers to the Agreement signed by duly authorized officers or representatives of the respective Parties, and the provisions hereof not specifically amended thereby shall remain in full force and effect. 

11.12 Counterparts. This Agreement may be executed in counterparts, each of which shall be deemed an original, but which together shall
constitute one and the same instrument. 
 [Remainder of page intentionally left blank; signature page follows] 

  
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IN WITNESS WHEREOF, the Parties hereto have caused their duly authorized representatives to execute this API Supply Agreement as of the Effective Date.

  

									
	 XERIS PHARMACEUTICALS, INC.
	 		 	 BACHEM AMERICAS, INC.

	By:	 	 /s/ Paul R. Edick
	 		 	By:	 	 /s/ Brian Gregg

	Name:	 	Paul R. Edick	 		 	Name:	 	Brian Gregg
	Title:	 	CEO	 		 	Title:	 	COO

  
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Exhibit 1 
 API PRICING

 Annual Price/Volume 
  

			
	 Price (per gram)
	  	 Annual Grams

	 $            /g
	  	[***]g
	 $            /g
	  	[***]g
	 $            /g
	  	[***] – [***]g
	 $            /g
	  	>[***]g

  
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EXHIBIT 2 
 RELEVANT
SHIPPING DOCUMENTATION 
 Certificate of Analysis 

Certificate of Conformance 
 TSE/BSE Safety Certificate 

Packing List invoice 
 Temperature data logger for BBU/TOR and/or
BBU/XERIS shipments 

  
 18

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