Document:

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                                                                    EXHIBIT 10.1

                        Amendment to Consulting Agreement

         This Amendment to Consulting Agreement (the "Amendment") is entered
into as of April 1, 2002, by and between Cephalon, Inc., a Delaware corporation
("Cephalon") and Martyn D. Greenacre ("Consultant").

         WHEREAS, Cephalon and Consultant have previously entered into a
Consulting Agreement (the "Consulting Agreement") dated as of October 1, 2001;

         WHEREAS, pursuant to the Consulting Agreement the Consultant has
provided Cephalon with valuable consulting services in connection with
Cephalon's acquisition of the French pharmaceutical company Laboratoire L.
Lafon;

         WHEREAS, Cephalon is considering undertaking other strategic
transactions that would expand its presence in Europe; and

         WHEREAS, Consultant has substantial expertise in the pharmaceutical
industry, particularly in Europe.

         NOW, THEREFORE, in consideration of the mutual promises set forth
herein, and intending to be bound legally hereby, Cephalon and Consultant hereby
agree as follows:

1. Amendments. The Consulting Agreement is hereby amended as follows, effective
   ----------
as of the date set forth above:

1.1. Section 2. Section 2 is hereby amended to extend the initial term of the
Consulting Agreement until December 31, 2002.

1.2  Section 6. Section 6 is hereby amended to provide that either Cephalon or
Consultant may terminate the Consulting Agreement for any reason whatsoever by
providing to the other thirty (30) days prior written notice of such
termination.

1.3  Exhibit A. Exhibit A is hereby amended by deleting existing Exhibit A in
its entirety and replacing it with the attached Exhibit A.

2. Other Matters.
   -------------

2.1  Except as amended hereby, the Consulting Agreement shall remain in full
force and effect.

2.2  This Amendment shall be binding on the parties and their respective
successors and assigns.

2.3  This Amendment shall be governed and interpreted in accordance with the
laws of the State of Delaware, without giving effect to any conflict of laws
provisions.

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         IN WITNESS WHEREOF, the undersigned have executed this Agreement as of
the date first written above.

                              CEPHALON, INC.

                              By: /s/ Frank Baldino, Jr., Ph.D.
                                  -----------------------------
                              Name:   Frank Baldino, Jr., Ph.D.
                              Title:  Chairman and Chief Executive Officer

                              MARTYN D. GREENACRE

                              By: /s/ Martyn D. Greenacre
                                  -----------------------------

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                                    Exhibit A

               Description of Consulting Services and Compensation

Scope of Services:            Consultant shall provide consulting services as
                              requested relating to the possible expansion of
                              Cephalon's European Operations.

Compensation:                 Cephalon shall pay Consultant a total of $19,200
                              per month as compensation for the Services as well
                              as travel, hotel, and meal expenses.

Schedule of Payments:         Cephalon shall pay Consultant twice each month
                              during the term of this Agreement.

Please send all invoices to:  Cephalon, Inc.
                              Attn:  Accounts Payable
                              145 Brandywine Parkway
                              West Chester, PA 19380<PAGE>

                                                                   EXHIBIT 10.44

                       INCARA PHARMACEUTICALS CORPORATION

                           1999 EQUITY INCENTIVE PLAN

1.   Purpose.

     The purpose of the Incara Pharmaceuticals Corporation 1999 Equity Incentive
Plan (the "Plan") is to provide incentives for Incara Pharmaceuticals
Corporation (the "Company") to attract, retain, motivate and provide incentive
to eligible persons whose contributions are important to the success of the
Company by offering them an opportunity to participate in the Company's future
through awards entitling such persons to acquire shares of the Company's Common
Stock, $0.001 par value ("Common Stock").

2.   Type of Awards and Administration.

     (a) Administration. The Plan will be administered by the Board of Directors
or the Compensation Committee of the Board of Directors (the "Committee"), whose
construction and interpretation of the terms and provisions of the Plan shall be
final and conclusive. The delegation of powers to the Committee shall be
consistent with applicable laws or regulations (including, without limitation,
applicable state law and Rule 16b-3 promulgated under the Securities Exchange
Act of 1934 (the "Exchange Act"), or any successor rule ("Rule 16b-3")). The
Board of Directors or the Committee shall have authority, subject to the express
provisions of the Plan, to grant Restricted Stock Awards (as defined in Section
5 below), to amend outstanding Restricted Stock Awards, to construe the
respective award agreements and the Plan, to prescribe, amend and rescind rules
and regulations relating to the Plan, to determine the terms and provisions of
the respective award agreements, which need not be identical, and to make all
other determinations in the judgment of the Board of Directors or the Committee
necessary or desirable for the administration of the Plan. The Board of
Directors or the Committee may correct any defect or supply any omission or
reconcile any inconsistency in the Plan or in any award agreement in the manner
and to the extent it shall deem expedient to carry the Plan into effect and it
shall be the sole and final judge of such expediency. No director or person
acting pursuant to authority delegated by the Board of Directors or the
Committee shall be liable for any action or determination under the Plan made in
good faith. Subject to adjustment as provided in Section 11 below, the aggregate
number of shares of Common Stock that may be subject to Restricted Stock Awards
granted to any person in a calendar year shall not exceed 500,000 shares.

     (b) Applicability of Rule 16b-3. Those provisions of the Plan which make
express reference to Rule 16b-3 shall apply only to such persons as are required
to file reports under Section 16(a) of the Exchange Act (a "Reporting Person").

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3.   Eligibility.

     (a) General. Restricted Stock Awards may be granted to persons who are, at
the time of grant, employees, officers or consultants of the Company as defined
in Sections 424(e) and 424(f) of the Code ("Participants"). A Participant who
has been granted a Restricted Stock Award may, if he or she is otherwise
eligible, be granted additional Restricted Stock Awards if the Board or the
Committee shall so determine.

     (b) Grant of Awards to Reporting Persons. The selection of an officer who
is a Reporting Person (as the term "officer" is defined for purposes of Rule
16b-3) as a recipient of Restricted Stock Award, the vesting of the Restricted
Stock Award and the number of shares subject to the Restricted Stock Award shall
be determined either by the Board of Directors or the Committee.

4.   Stock Subject to Plan.

     The stock subject to Restricted Stock Awards granted under the Plan shall
be shares of authorized but unissued or reacquired Common Stock. Subject to
adjustment as provided in Section 11 below, the maximum number of shares of
Common Stock of the Company which may be issued and sold under the Plan is
2,000,000 shares (the "Shares").

5.   Terms and Conditions of Awards of Restricted Stock.

     (a) General Terms. The Board of Directors or the Committee shall have full
and complete authority and discretion, except as expressly limited by the Plan,
to grant awards entitling the Participant to receive Shares of Common Stock
("Restricted Stock Award(s)") and to provide the terms and conditions (which
need not be identical among Participants) thereof. Restricted Stock Awards shall
be evidenced by written agreements ("Stock Award Agreements") in such form as
the Board or the Committee from time to time shall approve. In particular, the
Board or the Committee shall have the power to determine:

          (i) which of the Participants are eligible to receive Restricted Stock
     Awards under the Plan and the number of Shares to be subject to such
     awards;

          (ii) the vesting period or performance criteria, if any, applicable to
     each Restricted Stock Award, which period or criteria need not be the same
     for all Restricted Stock Awards;

          (iii) the payment, if any, to be made by the Participant in
     consideration of the Restricted Stock Award or the Shares subject to the
     Restricted Stock Award. Any Restricted Stock Award may be made for past
     services already rendered to the Company (provided that the Participant
     pays the Company in cash the par value of the Shares subject to the award)
     or may provide for payment of cash or deferred consideration which is less
     than the fair market value of the Common Stock subject to the award at the
     date of grant. Any such Restricted Stock Award may be on the basis that the
     Shares subject to the award may be repurchased by the Company at a fixed
     price or at a price established by formula upon specified circumstances;

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          (iv) the effect which specific events designated by the Board of
     Directors or the Committee are to have on the vesting period, which shall
     be incorporated into the related Stock Award Agreement executed by the
     Company and the Participant; and

          (v) the restrictions on transferability applicable to each Restricted
     Stock Award or the Shares subject to such award.

6.   Vesting of Stock Subject to Restricted Stock Awards.

     (a) Vesting Restrictions. Restricted Stock Awards shall be subject to the
restrictions, which shall be incorporated into the related Stock Award Agreement
executed by the Company and the Participant, that the Shares subject to such
awards:

          (i) may be subject to vesting periods based on continued employment or
     consulting with the Company; and/or

          (ii) may be subject to forfeiture for any portion of said Shares that
     do not vest.

     (b) Vesting Period. Vesting of Shares subject to Restricted Stock Awards
shall be at the times or upon the events determined by the Board or the
Committee at the time of grant and set forth in the applicable Stock Award
Agreement unless such vesting periods are accelerated in accordance with Section
12 below or extended in accordance with subsection (c) below.

     (c) Extension of Vesting. Unless waived by the Participant, the vesting
periods contained herein or in the applicable Stock Award Agreement shall be
subject to extension in the event the specified vesting period occurs during a
"Black-Out Period," as defined in the next sentence, on the terms and conditions
to be set forth in the applicable Stock Award Agreement. For purposes of the
Plan, "Black-Out Period" shall mean any period of time during which the
Participant is unable to sell Shares as a result of legal or contractual
restrictions on such sale, including but not limited to periods in which

          (i) the Participant is subject to a "lock-up" agreement with a third
     party executed in connection with a public offering or other financing
     transaction by the Company prohibiting the sale by Participant of shares of
     the Company's Common Stock for a specified period of time without such
     third party's consent,

          (ii) the Participant is subject to restrictions on trading imposed by
     the Company under applicable securities laws, or

          (iii) the Company prohibits the disposition of any or all of a
     Participant's Shares by limiting the number of Shares sold by a broker
     designated by the Company.

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7.   Nontransferability of Award.

     (a) No Restricted Stock Award granted under this Plan shall be assignable
or otherwise transferable by the Participant except by will or by the laws of
descent and distribution or pursuant to a qualified domestic relations order as
defined in the Internal Revenue Code (the "Code") or Title I of the Employee
Retirement Income Security Act, or the rules thereunder, except as set forth in
subsections (b), (c) and (d) hereof.

     (b) The Board of Directors or the Committee may, in its discretion,
authorize all or a portion of any Restricted Stock Awards granted to a
Participant to be on terms which permit transfer by such Participant to (i) the
spouse, children or grandchildren of the Participant ("Immediate Family
Members"), (ii) a trust or trusts for the exclusive benefit of the Participant
or such Immediate Family Members, or (iii) a partnership in which such Immediate
Family Members are the only partners (individually or collectively, the
"Permitted Transferee(s)"), provided that (w) the Restricted Stock Award must be
held by the Participant for a period of at least one month prior to transfer,
(x) there may be no consideration for any such transfer, (y) the Stock Award
Agreement pursuant to which such Restricted Stock Awards are granted must be
approved by the Board of Directors or the Committee, and must expressly provide
for transferability in a manner consistent with this Section, and (z) subsequent
transfers of transferred Restricted Stock Awards shall be prohibited except by
will or the laws of descent and distribution or pursuant to a qualified domestic
relations order as defined in the Code or Title I of the Employee Retirement
Income Security Act, or the rules thereunder. Following transfer, any such
Restricted Stock Awards shall continue to be subject to the same terms and
conditions as were applicable immediately prior to transfer, provided that for
purposes of the Plan the term "Participant" shall be deemed to refer to the
Permitted Transferee.

     (c) The events of termination of employment or consulting shall continue to
be applied with respect to the original Participant. A Restricted Stock Award
may be exercised during the lifetime of the Participant only by the Participant
or Permitted Transferees. In the event a Participant dies or becomes disabled
during his or her employment by the Company, his or her Restricted Stock Award
shall thereafter be exercisable, during the period specified in the award
agreement, by his or her executors or administrators to the full extent to which
such Restricted Stock Award was exercisable by the Participant at the time of
his or her death or disability.

     (d) Transfer or sale of the Restricted Stock Awards and/or Shares issued
upon satisfaction of Restricted Stock Awards are subject to restrictions on
transfer imposed by any applicable state and federal securities laws.

8.   Effect of Termination of Employment or Other Relationship.

     Except as otherwise determined by the Board or the Committee at the date of
grant of a Restricted Stock Award, and subject to the provisions of the Plan, a
Restricted Stock Award shall terminate immediately upon the termination of the
Participant's employment or consulting with the Company and all Unvested Shares
shall be forfeited.

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9.   Additional Award Provisions.

     The Board of Directors or the Committee may, in its sole discretion,
include additional provisions in agreements covering awards granted under the
Plan, including without limitation restrictions on transfer, purchase or
repurchase rights, rights of first refusal, or such other provisions as shall be
determined by the Board of Directors or the Committee; provided, that such
additional provisions shall not be inconsistent with any other term or condition
of the Plan.

10.  General Restrictions.

     (a) Investment Representations. The Company may require any person to whom
a Restricted Stock Award is granted, as a condition of the Company issuing
Shares upon vesting of such award, to (i) give written assurances in substance
and form satisfactory to the Company to the effect that such person is acquiring
the Shares subject to the award for his or her own account for investment and
not with any present intention of selling or otherwise distributing the same,
and to such other effects as the Company deems necessary or appropriate in order
to comply with federal and applicable state securities laws, or (ii) comply with
covenants or representations made by the Company in connection with any public
offering of its Common Stock, including executing any "lock-up" agreement or
other restriction on transferability.

     (b) Compliance With Securities Law. Each Restricted Stock Award shall be
subject to the requirement that if, at any time, the listing, registration or
qualification of the shares of Common Stock subject to such award upon any
securities exchange or automated quotation system or under any state or federal
law, or the consent or approval of any governmental or regulatory body, or that
the disclosure of non-public information or the satisfaction of any other
condition is necessary as a condition of, or in connection with the issuance or
purchase of Shares thereunder, the Company shall have no obligation to issue or
deliver certificates evidencing such Shares, in whole or in part, unless such
listing, registration, qualification, consent or approval, or satisfaction of
such condition shall have been effected or obtained on conditions acceptable to
the Committee or the Board of Directors. Nothing herein shall be deemed to
require the Company to apply for or to obtain such listing, registration or
qualification, or to satisfy such condition and the Company shall have no
liability for any inability or failure to do so.

11.  Adjustment Provisions for Recapitalizations, and Related Transactions.

     (a) Recapitalizations and Related Transactions. Subject to any required
action by the Company's stockholders, if, through or as a result of any
recapitalization, reclassification, stock dividend, stock split, reverse stock
split or other similar transaction, (i) the outstanding shares of Common Stock
are increased, decreased or exchanged for a different number or kind of shares
or other securities of the Company, or (ii) additional shares or new or
different shares or other non-cash assets are distributed with respect to such
shares of Common Stock or other securities, an appropriate and proportionate
adjustment shall be made in (x) the maximum number and kind of Shares reserved
for issuance under or otherwise referred to in the Plan, (y) the number and kind
of Shares or other securities subject to any then outstanding Restricted Stock
Awards under the Plan, and (z) the price, if any, for each Share subject to any
then outstanding Restricted Stock Awards

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under the Plan, without changing the aggregate purchase price as to which such
Restricted Stock Awards remain outstanding. Such adjustment shall be made by the
Board or the Committee, whose determination in that respect shall be final,
binding and conclusive. Notwithstanding the foregoing, no adjustment shall be
made pursuant to this Section 11 if such adjustment (i) would cause the Plan to
fail to comply with Rule 16b-3 or (ii) would be considered as the adoption of a
new plan requiring stockholder approval.

12.  Merger, Consolidation, Asset Sale, Liquidation, etc.

     (a) Trigger Events. A "Trigger Event" shall occur in the event of

          (i) the sale of all or substantially all of the assets of the Company
     or a consolidation or merger in which outstanding shares of Common Stock
     are exchanged for securities, cash or other property of any other
     corporation or business entity where the stockholders of the Company
     immediately prior to the merger or consolidation do not beneficially own,
     immediately after the merger or consolidation, shares of the corporation
     issuing cash or securities in the merger or consolidation entitling such
     stockholders to more than 50% of all votes (without consideration of the
     rights of any class of stock to elect directors by a separate class vote)
     to which all stockholders of such corporation would be entitled in the
     election of directors or in the event of a liquidation of the Company;

          (ii) the date the Company acquires knowledge that any person or group
     deemed a person under Section 13(d)-3 of the Exchange Act (other than the
     Company, any Subsidiary, any employee benefit plan of the Company or of any
     Subsidiary or any entity holding shares of Common Stock or other securities
     of the Company for or pursuant to the terms of any such plan or any
     individual or entity or group or affiliate thereof which acquired its
     beneficial ownership interest prior to the date the Plan was adopted by the
     Board), in a transaction or series of transactions, has become the
     beneficial owner, directly or indirectly (with beneficial ownership
     determined as provided in Rule 13d-3, or any successor rule, under the
     Exchange Act), of securities of the Company entitling the person or group
     to 50% or more of all votes (without consideration of the rights of any
     class of stock to elect directors by a separate class vote) to which all
     stockholders of the Company would be entitled in the election of directors
     were an election held on such date; or

          (iii) the date, during any period of two consecutive years, when
     individuals who at the beginning of such period constitute the Board of
     Directors of the Company cease for any reason to constitute at least a
     majority thereof, unless the election, or the nomination for election by
     the stockholders of the Company, of each new director was approved by a
     vote of at least two-thirds of the directors then still in office who were
     directors at the beginning of such period.

     (b) Trigger Event Vesting. The vesting of all or any outstanding Shares or
Restricted Stock Awards shall accelerate immediately prior to the specified
effective date of a Trigger Event and upon written notice to the Participants
holding such outstanding Shares or awards.

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     (c) Substitute Awards. The Company may grant awards under the Plan in
substitution for awards held by employees of another corporation who become
employees of the Company, or a subsidiary of the Company, as the result of a
merger or consolidation of the employing corporation with the Company or a
subsidiary of the Company, or as a result of the acquisition by the Company, or
one of its subsidiaries, of property or stock of the employing corporation, or
otherwise. Such substitution will be permissible if the holder of the
substituted award would have been eligible to be granted a Restricted Stock
Award under this Plan if the other Company had applied the rules of this Plan to
such grant. The Company may direct that substitute awards be granted on such
terms and conditions as the Committee or the Board of Directors considers
appropriate in the circumstances.

     (d) Other Treatment of Awards. Subject to any greater rights granted to
Participants under the foregoing provisions of Section 12, in the event of the
occurrence of any Trigger Event, any outstanding Restricted Stock Awards will be
treated as provided in the applicable agreement or plan of merger,
consolidation, dissolution, liquidation, sale of assets or other corporate
transaction.

13.  No Special Employment Rights.

     Nothing contained in the Plan or in any Restricted Stock Award shall confer
upon any Participant any right with respect to the continuation of his or her
employment or consulting by the Company or interfere in any way with the right
of the Company at any time to terminate such employment or consulting or to
increase or decrease the compensation of the Participant.

14.  Other Employee or Consulting Benefits.

     Except as to plans which by their terms include such amounts as
compensation, the amount of any compensation deemed to be received by an
employee or consultant as a result of the receipt of a Restricted Stock Award or
the sale of Shares issued in satisfaction of such award will not constitute
compensation with respect to which any other employee or consulting benefits of
such employee or consultant are determined, including, without limitation,
benefits under any bonus, pension, profit-sharing, 401(k), employee stock
purchase plan, life insurance or salary continuation plan, except as otherwise
specifically determined by the Board of Directors.

15.  Amendment of the Plan.

     (a) The Board of Directors or the Committee may at any time, and from time
to time, modify or amend the Plan in any respect; provided, however, that if at
any time the approval of the stockholders of the Company is required under Rule
16b-3 or any other applicable law or regulation, the Board of Directors or the
Committee may not effect such modification or amendment without such approval.

     (b) The modification or amendment of the Plan shall not, without the
consent of a Participant, affect his or her rights under an award previously
granted to him or her. With the consent of the Participant affected, the Board
of Directors or the Committee may amend outstanding award agreements in a manner
not inconsistent with the Plan. The Board of Directors or the

<PAGE>

Committee shall have the right to amend or modify the terms and provisions of
the Plan and of any outstanding award to the extent necessary to ensure the
qualification of the Plan under Rule 16b-3.

16.  Withholding.

     (a) The Company shall have the right to deduct from payments of any kind
otherwise due to the Participant any federal, state or local taxes of any kind
required by law to be withheld with respect to any Restricted Stock Awards
granted or Shares vesting under the Plan.

     (b) Whenever shares of Common Stock are to be issued in satisfaction of a
Restricted Stock Award under this Plan, the Company may require the Participant
to remit to the Company, as of the date that the amount of tax to be withheld is
to be determined, an amount sufficient to satisfy federal, state and local
withholding tax obligations prior to the delivery of the certificates for such
Shares, whether or not the Participant is in the employ of the Company at such
time.

     (c) If requested by the Company, each Participant may be required to agree
that sales of Shares subject to a Restricted Stock Award shall be sold by
Participant only through such broker-dealers, each of which is a member of the
National Association of Securities Dealers, Inc. ("NASD") as have been
designated by the Company (a "Designated Broker") whereby, upon the Participant
irrevocably electing to sell a portion of the Shares, the Designated Broker
irrevocably commits upon receipt of such Shares to forward directly to the
Company an amount sufficient to satisfy the federal, state and local withholding
tax obligation with respect to the vesting of the Shares.

     (d) Notwithstanding the foregoing, in the case of a Reporting Person whose
awards have been granted in accordance with the provisions of Section 3(b)
herein, no election to use Shares for the payment of withholding taxes shall be
effective unless made in compliance with any applicable requirements of Rule
16b-3, if applicable.

17.  Effective Date and Duration of the Plan.

     (a) Effective Date. The Plan shall be effective as of September 23, 1999.
Amendments to the Plan not requiring stockholder approval shall become effective
when adopted by the Board of Directors or the Committee. Subject to this
limitation, awards may be granted under the Plan at any time on or after the
effective date and before the date fixed for termination of the Plan.

     (b) Termination. Unless terminated earlier by the Board of Directors or the
Committee, the Plan shall terminate as of the close of business on September 22,
2009. Any awards outstanding on such date shall continue to have force and
effect in accordance with the provisions of the agreements evidencing such
awards.

18.  Provision for Foreign Participants.

     The Board of Directors or the Committee may, without amending the Plan,
modify awards granted to Participants who are foreign nationals or employed
outside the United States to recognize

<PAGE>

differences in laws, rules, regulations or customs of such foreign jurisdictions
with respect to tax, securities, currency, employee benefit or other matters.

19.  Governing Law.

     The provisions of this Plan shall be governed and construed in accordance
with the laws of the State of Delaware without regard to the principles of
conflicts of laws.

Adopted by the Board of Directors and the Compensation Committee of the Board of
Directors on September 23, 1999 and amended by the Board of Directors on May 3,
2002.

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