Document:

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                                                                 EXHIBIT 10.28

WHEN RECORDED, PLEASE RETURN TO:                     MORTGAGE PREPARED BY:
Choate, Hall & Stewart                               Choate, Hall & Stewart
One Exchange Place                                   One Exchange Place
53 State Street                                      53 State Street
Boston, Massachusetts 02109                          Boston, Massachusetts 02109
Attn: Peter M. Palladino, Esq.

                        MORTGAGE AND SECURITY AGREEMENT
                        -------------------------------
                            (Land and Buildings at
           Building 600, Glasgow Business Center, Newark, Delaware)

     THIS MORTGAGE AND SECURITY AGREEMENT (as from time to time amended and in
effect, hereinafter called this "Mortgage") is made as of the 21st day of
September, 2001 by HOLOGIC, INC. (together with any and all successors and
assigns, the "Mortgagor"), and is granted and delivered to FOOTHILL CAPITAL
CORPORATION, as collateral agent for the Lenders (together with any other holder
from time to time of the Loan Documents, called the "Lender").

                  1.  DEFINITIONS; GRANTING CLAUSE; PREMISES;
                      ---------------------------------------
                      SECURED OBLIGATIONS; CONDITIONS; TITLE.
                      --------------------------------------

          1.1  Definitions.  Any capitalized term used but not defined in this
               -----------
Mortgage shall have the same meaning for such term as defined in the Loan and
Security Agreement (the "Loan Agreement") dated as of September 21, 2001, by and
among Hologic, Inc., FluoroScan Imaging Systems, Inc., and Direct Radiography
Corporation, the Borrowers named on the signature page to the Loan Agreement,
the financial institutions from time to time party to the Loan Agreement, and
Foothill Capital Corporation, as arranger and administrative agent for the
Lenders.  Certain capitalized terms used in this Mortgage are specifically
defined as follows:

     "Assignment" shall mean the Assignment of Leases and Rents of even date
herewith granted by the Mortgagor to the Lender securing the Loan Documents and
covering the Premises, as from time to time amended in writing.

     "Collateral" shall mean all personal property owned by Mortgagor relating
to the Premises including, without limitation, all personal property of the type
set forth in Section 1.4 of this Mortgage.

     "Event of Default" shall mean each of the events set forth in Section 7.3
hereof; provided that, as used with reference to any of the other Loan
Documents, such term shall mean an event which constitutes a default under such
Loan Document and which is continuing, beyond the applicable grace period, if
any, specified therein.

     "Hazardous Materials" shall mean asbestos, flammable materials, explosives,
radioactive substances, polychlorinated biphenyls, other carcinogens, oil and
other petroleum products, pollutants, contaminants, and any other hazardous or
toxic materials, wastes and substances which are defined, determined or
identified as such in any present or future federal, state or local laws, rules,
codes or regulations the purpose of which is the protection of the environment,
or any judicial or administrative interpretation of such laws, rules, codes or
regulations.
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     "Hazardous Materials Legal Requirements" shall mean all present federal,
state or local laws, rules, codes or regulations, or any judicial or
administrative interpretation thereof, including, without limitation, all
orders, decrees, judgments and rulings imposed through any public or private
enforcement proceedings, relating to Hazardous Materials or the existence, use,
discharge, release, containment, transportation or disposal thereof, or
otherwise regulating or providing for the protection of the environment in
respect of or against any Hazardous Materials.

     "Leases" shall mean each present and future lease or any other agreement
for the use or occupancy of all or any portion of the Premises and the buildings
and other improvements which are part of the Premises, including any
modifications, extensions or renewals thereof.

     "Legal Requirements" shall mean collectively, all statutes, ordinances, by-
laws, codes, rules, regulations, restrictions, orders, judgments, decrees and
injunctions (including, without limitation, all applicable building, health
code, zoning, subdivision, and other land use statutes, ordinances, by-laws,
codes, rules and regulations), whether now or hereafter enacted, promulgated or
issued by any governmental authority, affecting the Premises or the maintenance,
management, repair, use, occupancy, possession or operation thereof, including,
without limitation, any of the foregoing which may (i) require repairs,
modifications or alterations in or to the Premises or (ii) in any way affect
(adversely or otherwise) the use and enjoyment of the Premises.

     "Lender's Mailing Address" shall mean:  Foothill Capital Corporation, One
Boston Place, 18th Floor, Boston, MA  02108, Attn:  Business Finance Division
Manager.

     "Loan" shall mean the transaction evidenced by the Loan Documents.

     "Mortgagor's Mailing Address" and "Mortgagor's Principal Place of Business"
shall mean: Hologic, Inc., 35 Crosby Drive, Bedford, Massachusetts 01730, Attn:
Chief Financial Officer.

     "Permitted Encumbrances" shall mean (i) the easements, restrictions and
encumbrances, if any, existing of record as of the date of this Mortgage, and
(ii) liens for real property taxes not yet delinquent, and (iii) Leases entered
into or effected after the date hereof without violating the provisions of the
Assignments of Leases and Rents.

     "Premises" shall mean the real estate, together with all buildings,
structures and improvements now or hereafter located thereon, if any, and all
appurtenances, fixtures and other items of similar nature, known as the land and
building(s) located at Building 600, Glasgow Business Center, Newark, Delaware,
and more particularly described in Section 1.4 hereof and Exhibit A to this
                                                          ---------
Mortgage.

     "Security" shall mean all assets now or from time to time hereafter
encumbered or subjected to a lien, security interest or charge (or intended or
required so to be) pursuant to this Mortgage or any of the other Loan Documents
to secure any or all of the Obligations.

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     "Taking" shall mean a taking by eminent domain or condemnation for public
use of, or any damage by reason of the action of any public or governmental
entity or authority to, all or any part of the Premises.

          1.2  Granting Clause.  For good and valuable consideration, the
               ---------------
receipt and sufficiency of which are hereby acknowledged, the Mortgagor hereby
grants, mortgages and conveys the Premises to the Lender, and grants to the
Lender a first security interest in so much of the Premises as constitutes
Collateral, to secure the Obligations.

          1.3  Future Advances.  As set forth in the Loan Agreement, the Maximum
               ---------------
Revolver Amount of any and all advances provided by Lenders to Mortgagor shall
be $25,000,000.00.  This Mortgage secures a maximum amount of up to 150% of the
amount of the Maximum Revolver Amount.  This Mortgage shall secure any
additional loans as well as any and all present or future advances and
readvances under the Loan Documents made by Lender to or for the benefit of
Borrower or the Premises, all of which shall be entitled to the benefits of this
Mortgage under 25 Del. Code Section 2118 and shall have the same lien priority
as if the future loans, advances, or readvances were made as of the date hereof,
including, without limitation: (a) principal, interest, late charges, fees, and
other amounts due under the Loan Documents; (b) all advances by Lender to
Mortgagor or any other person to pay costs of erection, construction,
alteration, repair, restoration, maintenance and completion of any improvement
on the Premises; (c) all advances made or costs incurred by Mortgagor for the
payment of real estate taxes, assessments or other governmental charges,
maintenance charges, insurance premiums, appraisal charges, environmental
inspection, audit, testing, or compliance costs and costs incurred by Lender for
the enforcement and protection of the Premises or the lien of this Mortgage; and
(d) all reasonable legal fees, cost and other expenses incurred by Lender by
reason of any Event of Default or otherwise in connection with the Loan
Documents. Mortgagor agrees that if, at any time during the term of this
Mortgage or following a foreclosure hereof, Mortgagor fails to perform or
observe any covenant or obligation under this Mortgage including, without
limitation, payment of any of the foregoing, Lender may (but shall not be
obligated to) take such steps as are reasonably necessary to remedy any such
nonperformance or nonobservance and provide payment thereof. All amounts
advanced by Lender shall be added to the amount secured by the Mortgage and
shall be due and payable promptly after demand, together with interest at the
rate of interest in effect under the Loan Documents, such interest to be
calculated from the date of such advance to the date of repayment thereof.
Mortgagor's obligations hereunder shall be continuing and shall survive
notwithstanding a foreclosure of this Mortgage.

          1.4  The Premises; the Collateral.  (a) The real estate included in
               ----------------------------
the Premises is more particularly described in Exhibit A attached hereto.  The
                                               ---------
Premises include:  all buildings, structures and other improvements now or
hereafter existing thereon; all rights-of-way or uses, servitudes, licenses,
tenements, hereditaments, appurtenances, easements, profits, mineral rights and
other rights now or hereafter existing, belonging or pertaining thereto; all
fixtures and other articles of every kind and nature whatsoever now or hereafter
owned or leased by the Mortgagor, and used or procured for use in connection
with the operation and maintenance of any of the foregoing, insofar as the same
are, or can by agreement of the parties be made, a part of the real estate.

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               (b)  The Collateral includes all personal property, including,
without limitation, all goods, equipment, inventory, accounts, documents,
instruments, chattel paper and general intangibles (each as defined in the
Uniform Commercial Code), now or hereafter owned by the Mortgagor and now or
hereafter placed in or on, or used or created in connection with the operation
or maintenance of, the Premises, and the proceeds and products thereof (cash and
noncash) and replacements therefor and accessions and additions thereto,
including all of the Mortgagor's rights (but none of its obligations) under all
contracts, agreements, leases, tenancies, deposits, escrows, claims and actions
(including, without limitation, any litigation, insurance and condemnation
awards and proceeds therefrom), and all warranties and guarantees related to all
or any portion of the Premises, including, without limitation, all purchase and
sale agreements now or hereafter entered pertaining to the Premises or portions
thereof, and including all of the Mortgagor's rights and interests in any
property, permits and approvals for the construction, ownership, use, occupancy,
maintenance and operation of the Premises. To the greatest extent practicable,
all references in this Mortgage to the Premises shall be deemed also to include
the Collateral.

          1.5  Conditions of this Mortgage.  This Mortgage is upon the condition
               ---------------------------
that all representations, warranties, conditions, covenants and agreements of
the Mortgagor contained herein and in each of the other Loan Documents be true
and correct, and be kept, observed and fully performed and satisfied.

          1.6  Title to the Premises; First Lien.  Mortgagor covenants that
               ---------------------------------
Mortgagor has good and clear record and marketable title in fee to such of the
Premises as is real property and has the right to mortgage, grant and convey the
Premises, and good and marketable absolute title to the balance of the Premises,
in either case subject to no liens, encumbrances, easements or restrictions
other than the Permitted Encumbrances; and this Mortgage is and will remain a
valid, enforceable and perfected first lien on, and security interest in, the
Premises.

                 2.  PROVISIONS REGARDING HAZARDOUS MATERIALS.
                     ----------------------------------------

          2.1  Warranties and Representations.  The Mortgagor represents and
               ------------------------------
warrants to the Lender that, except as disclosed in the Phase I Environmental
Site Assessment Report included in Schedule 5.14 of the Loan Agreement, there
are no Hazardous Materials located in, on or under the Premises except in strict
compliance with all Hazardous Materials Legal Requirements, and that, to the
best of the Mortgagor's knowledge, there are no Hazardous Materials located in,
on or under any real property adjoining or in the vicinity of the Premises which
through soil or groundwater migration could come to be located upon or under the
Premises.

          2.2  Compliance with Laws.  The Mortgagor agrees to comply, and to
               --------------------
cause the Mortgagor to comply, duly and fully with all Hazardous Waste Legal
Requirements applicable to the Premises and agrees promptly to undertake and
diligently to pursue to completion appropriate and legally authorized remedial
containment and clean-up actions in the event of any release of any Hazardous
Material on, upon, into or under the Premises.

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          2.3  Indemnification of the Lender.  The Mortgagor hereby agrees to
               -----------------------------
indemnify, defend and hold harmless the Lender from and against all loss,
liability, damage and expense, including reasonable attorneys' fees, occasioned
by or associated with (a) the Mortgagor's failure to comply duly and fully with
any Hazardous Materials Legal Requirement applicable to the Premises, (b) any
Hazardous Materials located on, upon, into or under the Premises, (c) any and
all damage to real or personal property or natural resources and/or harm or
injury to persons alleged to have resulted from any such Hazardous Materials, or
(d) the Lender's exercising in whole or in part, or failing or neglecting to
exercise, any of its rights under Section 2.4 below.

          2.4  Lender's Right to Make Site Assessments; Take Action.  The Lender
               ----------------------------------------------------
is hereby specifically authorized in its reasonable discretion to cause one or
more environmental site assessments of the Premises to be undertaken at the sole
cost and expense of the Mortgagee, at any time, and at the sole cost and expense
of Mortgagor, after the occurrence of an Event of Default.  Environmental site
assessments may include a detailed visual inspection of the Premises, including,
without limitation, all storage areas, storage tanks, drains, drywells and
leaching areas, as well as the making of ground borings and the taking of soil
samples, surface water samples and groundwater samples, and such other
investigations or analysis as is necessary or appropriate for a complete
assessment of the compliance of the Premises and the use and operation thereof
with all Hazardous Materials Legal Requirements.  Without limiting the
foregoing, in the event that there shall occur a release of Hazardous Materials
on, upon, into or under the Premises, or such a release appears imminent or
probable, the Lender shall have the right (but not the obligation), upon prior
notice to the Mortgagor (or without notice in the case of emergency), to cause
the release to be contained and/or removed on behalf of the Mortgagor or to
attempt to prevent or contain such a release.  The Mortgagor agrees to cooperate
with the Lender and to render such assistance to the Lender as may be requested
to facilitate such remedial actions (including, without limitation, such
containment or removal).  The Mortgagor shall be liable to the Lender for all
costs and expenses, including reasonable attorneys' fees, incurred on account of
such remedial action undertaken on the Mortgagor's behalf and shall reimburse
the Lender therefor on demand, and such costs shall be deemed included in the
Obligations.

          2.5  Survival of the Mortgagor's Obligations.  All of the Mortgagor's
               ---------------------------------------
obligations owed to the Lender under this Article 2, including, without
limitation, the indemnification obligation set forth in Section 2.3 above, shall
survive the payment of the Loan Documents and the discharge of this Mortgage in
all respects.  It is the intent of this Article 2 that the Lender shall at all
times remain fully indemnified and protected by the Mortgagor from any and all
liability which the Lender might incur as a result of the Mortgagor's failure to
comply duly and fully with any Hazardous Materials Legal Requirement applicable
to the Premises or otherwise arising from any Hazardous Materials on the
Premises which existed on, or were introduced to, the Premises during the term
of the Mortgagor's ownership thereof.

                        3.  COVENANTS OF THE MORTGAGOR.
                            --------------------------

          3.1  Construction and Completion of Improvements.  All buildings,
               -------------------------------------------
structures and other improvements hereafter constructed on the Premises shall be
completed by the

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Mortgagor in a good and workmanlike manner, in accordance with all applicable
governmental laws, statutes, ordinances, by-laws, codes, rules, regulations and
requirements, and approved in advance and in writing by the Lender, which
approval shall not be unreasonably withheld or delayed as to non-structural
improvements, and otherwise in accordance with the provisions of the Loan
Documents. Notwithstanding the foregoing, Mortgagor may from time to time make
alterations, additions or improvements to the Premises, without the approval of
Lender, provided: (i) the cost thereof shall not exceed Thirty Thousand Dollars
($30,000) in the aggregate in any consecutive twelve-month period; (ii)
Mortgagor shall, prior to commencing any such alterations, additions and/or
improvements or approving any lessee alterations, additions, or improvements in
the Premises in connection therewith, furnish Lender with a complete set of
plans and specifications for any such alterations, additions and/or
improvements; and (iii) such alterations, additions and/or improvements shall
not involve or affect the exterior or the structure of the Building or any of
the mechanical, electrical or plumbing systems of the Building.

          3.2  Prohibition Against Encumbrances; Restrictions on Transfer.  (a)
               ----------------------------------------------------------
The Mortgagor shall not, directly or indirectly, permit or suffer to be created
or to remain, and shall discharge, or promptly cause to be discharged, any
mortgage, lien, attachment, or other encumbrance on the Premises or any part
thereof or interest therein, other than the Loan Documents and Permitted
Encumbrances.  The Mortgagor shall promptly give the Lender notice of and,
unless the Lender requests otherwise, appear in and diligently contest at the
Mortgagor's sole cost and expense, any action or proceeding which purports to
affect the Mortgagor's title to the Premises or the priority or validity of this
Mortgage.

               (b)  Except for the Permitted Encumbrances, the Mortgagor shall
not, directly or indirectly, without the prior written consent of Lender in each
instance obtained, which consent may be withheld in Lender's sole discretion,
convey, sell, assign, transfer, dispose of (or permit any conveyance, sale,
assignment, transfer or disposition, whether voluntary or involuntary, of)
ownership or control of all or any part of any legal or beneficial interest in:
(i) the Premises or any part thereof (including any grant of a mortgage, other
lien or security interest in any legal or beneficial interest in the Premises or
any part thereof, or any sale, assignment, transfer or disposition of any rents
and other contractual claims), or (ii) the Mortgagor (collectively or
individually, a "Transfer"). Any sale or transfer (or cumulative sales or
transfers) of the capital stock of the Mortgagor in excess of 25% shall
constitute a transfer; provided, however, such sale or transfer of capital stock
shall not be deemed a transfer so long as Mortgagor is an entity whose
outstanding stock is listed on a recognized security exchange.

          3.3  Operation of Premises.  (a) The Mortgagor shall make such repairs
               ---------------------
and replacements and take such other steps as may be necessary to keep and
maintain the Premises in compliance with all Legal Requirements and in at least
as good repair, order and condition as the same now are or hereafter may be put
while this Mortgage is outstanding, excepting only deterioration incidental to
reasonable wear and use and any Taking; it being understood, however, that the
foregoing exception for reasonable wear and use shall not relieve the Mortgagor
from the obligation to repair or replace worn out, inoperative or otherwise
deficient elements of the Premises.

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               (b)  The Mortgagor shall not (except as otherwise expressly
permitted in this Mortgage or otherwise consented to in advance and in writing
by the Lender) permit or suffer the removal, demolition or any other waste of
any of the Premises, except that nothing in this Mortgage shall be deemed to
prevent replacements or substitutions for items constituting part of the
Collateral where such replacements and substitutions are comparable as to
function, quality and value.

               (c)  The Mortgagor shall fully and seasonably keep, observe and
satisfy all federal, regional, state and local laws, statutes, ordinances,
by-laws, codes, rules and regulations applicable to the Premises or the
occupancy or use thereof.

               (d)  The Mortgagor shall not make or permit any structural or
nonstructural alterations, improvements or additions to the Premises, except as
permitted in Section 3.1.

               (e)  The Mortgagor shall permit the Lender and its authorized
representatives to enter and examine the Premises from time to time, at all
reasonable times, in accordance with the terms of each lessee's lease and
without unreasonable interference with lessees' use and occupancy of the
Premises.

          3.4  Payments.  (a) The Mortgagor shall pay or cause to be paid,
               --------
promptly when due:  (i) all taxes, betterments, assessments and other
governmental levies, water rates, sewer charges, insurance premiums and other
charges, to whomever and whenever laid or assessed, whether on the Premises,
this Mortgage, any of the other Loan Documents or on any interest therein, or
any other debt or obligation expressly secured hereby (collectively, the
"Impositions"); and (ii) all federal, state and other taxes of whatever kind and
nature which could, if unpaid, result in a lien on the Premises or on any
interest therein.  Mortgagor may contest the validity or amount of such
Impositions, provided that: (i) the non-payment thereof does not pose a threat
of loss or seizure of the Building or interest of Mortgagor or Lender therein or
impose any fee or penalty against Mortgagor; (ii) Mortgagor notifies Lender of
such contest and thereafter diligently proceeds with such contest in accordance
with Law; and (iii) Lender may require Mortgagor to post a bond or other
collateral reasonably satisfactory to Lender in connection with such action.

               (b)  At any time following an Event of Default, if requested in
writing by the Lender, the Mortgagor shall deposit with the Lender, on a monthly
basis (each of which dates is hereinafter referred to as a "Monthly Tax Deposit
Date") until the payment in full of the Obligations, a sum equal to one-twelfth
(1/12) of the Impositions to be levied, charged, filed, assessed or imposed upon
or against the Premises and/or the Collateral within one (1) year after said
Monthly Tax Deposit Date.  If the amount of the Impositions to be levied,
charged, assessed or imposed within the ensuing one (1) year period shall not be
fixed upon any Monthly Tax Deposit Date, such amount for the purpose of
computing the tax deposit to be made by the Mortgagor hereunder shall be
estimated by the Lender, with an appropriate adjustment to be promptly made
between the Mortgagor and the Lender as soon as the fixed amount of such
Impositions is determinable.

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     The sums deposited by the Mortgagor under this Section 3.4(b) shall be held
by the Lender and shall be applied in payment of the Impositions when due.  Such
deposits shall not be commingled with other assets of the Lender except for
other real estate tax escrows in connection with other properties, and shall be
held in trust in an account at a recognized financial institution selected by
the Lender.  The Mortgagor shall give twenty (20) days' prior written notice to
the Lender in each instance when an Imposition is due, specifying the Imposition
to be paid and the amount thereof, the place of payment and the last day on
which the same may be paid.

     If for any reason the sums on deposit with the Lender under this Section
3.4(b) shall not be sufficient to pay an Imposition not later than thirty (30)
days before the last day on which the same may be paid without penalty or
interest, then, within ten (10) days after demand by the Lender, the Mortgagor
shall deposit sufficient sums so that the Lender may pay such Imposition in
full, together with any penalty and interest thereon.  The Lender may change its
estimate of any Imposition for any period on the basis of a change in an
assessment or tax rate or on the basis of a prior miscalculation or for any
other reason; in which event, within ten (10) days after demand by the Lender,
the Mortgagor shall deposit with the Lender the amount in excess of the sums
actually deposited which would theretofore have been payable under the revised
estimate.

     If any Imposition shall be levied, charged, filed, assessed or imposed upon
or against the Premises and/or the Collateral and if such Imposition shall also
be a levy, charge, assessment or imposition upon or for any other real or
personal property not covered by the lien of this Mortgage, then the computation
of the amounts to be deposited under this Section 3.4(b) shall be based upon the
entire amount of such Imposition and the Mortgagor shall not have the right to
apportion any deposit with respect to such Imposition.

     Upon an assignment of this Mortgage by the Lender, the Lender shall have
the right to transfer all amounts deposited pursuant to the provisions of this
Section 3.4(b) and still in its possession to such assignee (as the subsequent
holder of this Mortgage) which agrees to hold such funds in accordance with the
foregoing terms, and the original Lender named herein shall thereupon be
completely released from all liability with respect to such tax deposits and the
Mortgagor shall look solely to said assignee (as the subsequent holder of this
Mortgage) in reference thereto.

     All amounts deposited with the Lender pursuant to the provisions of this
Section 3.4(b) shall be held by the Lender as additional security for the sums
secured by this Mortgage and upon the occurrence of any Event of Default
hereunder the Lender may, in its sole and absolute discretion, apply said
amounts toward payment of the Obligations.  Upon the complete payment and
performance of the Obligations, any sums then held by the Lender under this
Section 3.4(b) shall be refunded to the Mortgagor.

     At the option of the Lender, after request therefor, the Mortgagor shall
deliver to the Lender copies of all notices, demands, claims, bills and receipts
in relation to the Impositions immediately upon the receipt thereof by the
Mortgagor.

          3.5  Copies of Notices to Lender.  The Mortgagor shall deliver to the
               ---------------------------
Lender promptly upon receipt of the same, copies of all notices, certificates,
documents and instruments

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<PAGE>

received by the Mortgagor from any agency or authority having jurisdiction over
the Premises, or any insurer of the Premises, which materially affect the
Premises or its occupancy or use.

          3.6  Intentionally Omitted.
               ----------------------

          3.7  Appraisals.  The Mortgagor agrees that the Lender shall have the
               ----------
right, not more than once per year, at any time so long as the Loan remains
outstanding, to order an appraisal or appraisals of the Premises if reasonably
required by the Lender to administer the Loan or required of the Lender by any
regulatory agency or authority having jurisdiction over the Lender, the
reasonable cost of which shall be paid by Mortgagor.

                4.  SECURITY AGREEMENT COVERING THE COLLATERAL.
                    ------------------------------------------

     4.1  Financing Statements; Further Assurances.  Subject to the terms of the
          ----------------------------------------
Loan Documents, the Mortgagor hereby covenants and agrees with the Lender that
as of the execution hereof and hereafter from time to time when requested by the
Lender, the Mortgagor shall (a) duly execute and deliver to the Lender, in form
appropriate for recording and filing, a security agreement and/or financing
statement or statements relating to the Collateral or any part thereof, it being
further agreed that the Lender may record or file a carbon, photographic or
other reproduction of a financing statement or this Mortgage in lieu of any
originally signed financing statement or statements; and (b) provide to the
Lender such other assurances as may be required by the Lender to establish,
preserve, perfect and protect the Lender's first and prior security interest in
the Collateral.

     4.2  Warranties; Representations; Covenants.  The Mortgagor hereby
          --------------------------------------
represents and warrants to, and covenants and agrees with, the Lender that (a)
the Collateral is and shall be used primarily for business purposes and is not
and shall not be bought, leased or used primarily for personal, family or
household purposes, and (b) except for Permitted Encumbrances, no financing
statement, security agreement or other lien instrument covering all or any part
of the Collateral or any proceeds thereof is on file in any public office.

     4.3  Procedure for Sale.  The Mortgagor hereby agrees that whenever
          ------------------
notification with respect to the sale or other disposition of the Collateral
(including collateral in which the Lender has been granted a security interest
pursuant to the Loan Documents) is required by law, such notification of the
time and place of public sale, or of the date after which a private sale or
other intended disposition is to be made, shall be deemed reasonable if given at
least ten (10) days before the time of such public sale or the date after which
any such private sale or other intended disposition is to be made, as the case
may be.  Further, the Lender shall be authorized and permitted to entirely or
partially postpone, adjourn, continue and reschedule any such sale, once or
several times, and entirely or partially all without prejudice or breach of any
duty or obligation of the Lender.

                   5.  EMINENT DOMAIN; APPLICATION OF AWARD.
                       ------------------------------------

     In case of any Taking of all or any part of the Premises or the
commencement of any proceedings or negotiations which might result in a Taking,
the Mortgagor shall promptly give

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written notice thereof to the Lender, generally describing the nature and extent
of the Taking and any proceedings or negotiations regarding the Taking. The
Lender may, at its option, appear in any proceeding in connection with, or any
negotiations relating to, a Taking and the Mortgagor shall promptly give to the
Lender copies of all notices, pleadings, determinations and other papers in any
such proceedings or negotiations. The Mortgagor shall in good faith and with due
diligence and counsel reasonably satisfactory to the Lender file and prosecute
the Mortgagor's claim or claims for any award or payment on account of any
Taking of the Premises; and if the Mortgagor does not so prosecute its claim,
then the Lender, in its reasonable judgment, shall have the right to file and
prosecute such claim at the Mortgagor's sole cost and expense. The Mortgagor
shall not settle any such claim or claims for less than the Secured Debt without
the Lender's prior written consent which consent shall not be unreasonably
withheld or delayed. The Mortgagor hereby assigns to the Lender all of the
Mortgagor's right, title and interest in and to any claim to damages or to
participation in any award in connection with a Taking and hereby irrevocably
authorizes such awards to be paid directly to the Lender. If the Mortgagor
collects any such claim or claims, by settlement, judicial decree or otherwise,
the Mortgagor shall promptly pay the same to the Lender. Any such awards, after
deducting therefrom all costs and expenses, including reasonable attorneys'
fees, incurred by the Lender in connection therewith, shall be applied by the
Lender in accordance with the provisions of Section 6.6 below.

                           6.  INSURANCE; CASUALTY.
                               -------------------

          6.1  Coverage.  The Mortgagor shall, at the Mortgagor's sole cost and
               --------
expense, obtain and keep in force while this Mortgage is on record, the
following insurance coverage: (a) casualty insurance in amounts reasonably
required by the Lender against all risks of physical loss, covering the
improvements from time to time constituting a part of the Premises and
equipment, supplies and materials furnished, with such deductibles as the Lender
may approve; (b) comprehensive public liability insurance in such amounts (which
amounts shall not be less than $1,000,000.00) and covering such matters as are
reasonably satisfactory to the Lender; (c) worker's compensation insurance
(including employer's liability insurance, if requested by the Lender) for all
employees of the Mortgagor engaged on or with respect to the Premises in such
amounts as are reasonably satisfactory to the Lender, but not less than such
amounts as may from time to time be established by law; and (d) such other
insurance coverages in such amounts and such additional amounts for existing
coverages as may from time to time, in light of requirements of mortgagees of
similar premises, be reasonably required by the Lender.

          6.2  Certain Policy Provisions.  The policies of insurance provided
               -------------------------
for in Sections 6.1 shall designate the Lender as an additional insured as to
the Premises and shall provide that the Lender is the mortgagee and loss payee
thereunder and that any proceeds shall be payable to the Lender, as its
interests may appear, pursuant to a standard mortgagee endorsement.  All such
policies issued by the respective insurers shall provide that the loss, if any,
thereunder shall be adjusted and paid as provided in this Mortgage.  All
policies of insurance provided for in this Article 6 shall also provide:  (a)
that such policies shall not be cancelled or amended without at least thirty
(30) days' prior written notice to the Lender; (b) that any amount payable due
to loss shall be payable to the Lender, notwithstanding any act or omission or
negligence of the Mortgagor which might otherwise result in forfeiture of, or

                                       10
<PAGE>

defense of a claim under, said insurance; and (c) that the insurer waives all
rights of set off, counterclaim or deduction against the Mortgagor.

          6.3  Carriers; Evidence of Insurance.  All insurance provided for in
               -------------------------------
this Article 6 shall be effected with insurers approved in advance and in
writing by the Lender.  Upon delivery hereof, and thereafter, not less than
fifteen (15) days prior to the expiration dates of the expiring policies,
originals of the policies provided for in this Article 6, in form and content
satisfactory to the Lender, shall be delivered by the Mortgagor to the Lender.

          6.4  Assignment of Policies Upon Foreclosure.  In the event of
               ---------------------------------------
foreclosure of the Mortgage or other transfer of title or assignment of the
Premises, in whole or in part, all right, title and interest of the Mortgagor in
and to all policies of insurance required by this Article 6 above shall
automatically inure to the benefit of, and pass to, the Lender or the Lender's
successor in interest or the purchaser or grantee of the Premises.

          6.5  Fulfillment of Conditions and Prosecution of Claims.  The
               ---------------------------------------------------
Mortgagor shall perform, observe and keep all the conditions of all insurance
policies covering the Premises and, in case of any loss or damage or claim, the
Mortgagor shall forthwith give immediate notice by mail to the Lender.  The
Mortgagor shall in good faith and with due diligence and counsel satisfactory to
the Lender prosecute any claim or claims relating to such loss or damage; and if
the Mortgagor does not so prosecute its claim, then the Lender shall have the
right to file and prosecute such claim at the Mortgagor's sole cost and expense.
Each insurance company is hereby authorized and directed to make payment for
such loss directly to the Lender instead of to the Mortgagor.  If in fact, the
Mortgagor in good faith and diligently prosecutes such claim, then such claim
shall be adjusted by the Mortgagor only but with the prior written consent of
the Lender, such consent not to be unreasonably withheld or delayed.  The
insurance proceeds for each such loss or damage, after deducting all costs and
expenses, including reasonable attorneys' fees incurred by the Lender in
connection therewith, under any policy provided for in this Section 6, shall be
paid to the Lender, and shall be applied by the Lender in accordance with
Section 6.6. below.  Except to the extent insurance proceeds are actually
retained by the Lender and applied to the Obligations, nothing herein shall be
deemed to relieve the Mortgagor from the obligation to maintain and repair the
Premises and to restore the Premises from all damage and destruction, regardless
of whether or not sufficient proceeds are available.  Further, such retention
and application shall be deemed a cure or waiver of any Event of Default under
this Mortgage.

          6.6  Application of Proceeds.  Subject to the terms and conditions of
               -----------------------
the Loan Documents, all proceeds received by the Lender with respect to a taking
of the Premises and all insurance proceeds with respect to fire or other insured
casualty, shall be applied as follows, in the order of priority indicated:

               (a) to reimburse the Lender for any costs and expenses, including
               reasonable attorneys' fees, incurred in connection with
               collecting said proceeds;

                                       11
<PAGE>

               (b) to the payment of all unpaid interest accrued on the Loan
               Documents;

               (c) to reimburse the Mortgagor for any reasonable costs and
               expenses, including reasonable attorneys' fees, incurred in
               connection with collecting said proceeds;

               (d) to the prepayment of the unpaid principal balance of the Loan
               Documents, without premium; and

               (e) to the Mortgagor or to such other person as may be entitled
               to receive the same;

provided however, that subject to the terms and conditions of the Loan
Documents, in the event of a taking of less than the entire Premises or in the
case of fire or other insured casualty which destroys less than all or
substantially all of the Premises, the Lender shall apply the proceeds first in
accordance with clause (a) of this Section until reimbursed in full and, if and
so long as (1) the Lender determines, in the reasonable exercise of its
discretion, that the restoration, replacement and rebuilding of the Premises can
be accomplished with available proceeds (or if such proceeds are not adequate
for repair, the Mortgagor agrees to supplement such proceeds with its own funds
so that adequate funds are available for repair), (2) the leases, if any,
affecting the Premises will continue in force and effect throughout, and at the
completion of, such restoration, replacement or rebuilding, and (3) no Event of
Default exists, the Lender shall apply the proceeds first in accordance with
clause (a) of this paragraph until reimbursed in full, then to the restoration,
replacement and rebuilding of the Premises, with advances of such proceeds being
made on a customary construction lending basis, until completion of such
restoration, repair or replacement and then in accordance with (b), (c), (d) and
(e) of this Section in that order of priority.

                    7.  RIGHTS AND REMEDIES OF THE LENDER.
                        ---------------------------------

          7.1  Rights Exercisable Regardless of Default.  Whether or not an
               ----------------------------------------
Event of Default (defined in Section 7.3 below) or any event which, with the
giving of notice or the passage of time or both would constitute an Event of
Default, exists under this Mortgage, the Lender shall have the following rights:

               (a)  The Lender is hereby specifically authorized to make, at the
Lender's sole option, any or all payments required to be made either hereunder,
or otherwise by the Mortgagor in connection with the Premises or any of the
transactions contemplated by the Loan Documents.  Such payments may include, but
are not limited to, payments for taxes, assessments, betterments and other
governmental levies, and charges, water rates, insurance premiums, maintenance,
repairs or improvements constituting a part of the Premises.  The Lender shall
have the right, but not the duty, to perform any obligations of the Mortgagor
relating to the Premises, without waiving any other rights or releasing the
Mortgagor from any obligation hereunder.

                                       12
<PAGE>

               (b)  The Lender shall have the right, but not the duty, to
intervene or otherwise participate in any legal or equitable proceeding which,
in the Lender's reasonable judgment, affects the Premises or any of the rights
created or secured by any of the Loan Documents. Such rights may be exercised by
the Lender at any time, but only after notice to the Mortgagor, and only to the
extent permitted by law and necessary to protect its rights hereunder and in the
Premises, and shall be at its sole expense prior to the occurrence of any Event
of Default, and at Mortgagor's cost and expense subsequent to the occurrence of
an Event of Default.

          7.2  Effect of Exercise of Rights.  Any sums paid, and any costs or
               ----------------------------
expenses, including reasonable attorneys' fees reasonably incurred by the
Lender, pursuant to the Lender's exercise of rights specified or referred to
herein or any of the Loan Documents, shall as between the parties hereto and
their successors-in-interest, be deemed valid, so that in no event shall the
necessity or validity of any such payments, costs or expenses be disputed.

          7.3  Events of Default.  The occurrence of any one or more of the
               -----------------
following events (each, an "Event of Default") shall constitute a default under
and breach of this Mortgage: (a) an Event of Default under the Loan Agreement,
(b) any breach of Sections 3.2(b) or 3.4 of this Mortgage, or (c) any breach of
any other provision of this Mortgage that is not cured within thirty (30) days
after written notice from Lender but, in the event the breach is not capable of
cure within such thirty (30) day period, it shall be an Event of Default only if
Mortgagor fails to commence to cure such breach within such thirty (30) day
period and diligently prosecute such cure to completion thereafter.

          7.4  Remedies; Rights and Remedies Cumulative.  Upon the occurrence of
               ----------------------------------------
any Event of Default, the Lender may at any time thereafter, at its option and
without notice exercise any or all of the following rights and remedies in
addition to (and not in limitation of) any and all other rights or remedies
available to it under applicable law as a mortgagee/secured party: (a) declare
all of the Obligations due and payable, and the Obligations shall thereupon
become and be immediately due and payable, anything in any of the Loan Documents
to the contrary notwithstanding, provided that, notwithstanding and without
limiting the generality of the foregoing, upon the occurrence of an Event of
Default under Section 7.3 hereof, all of the Obligations automatically shall
become and be immediately so due and payable; (b) apply to the Obligations any
deposits or other sums credited by or due from the Lender to the Mortgagor
including, without limitation, funds held in any real estate tax or other escrow
account held by or on behalf of the Lender (without first enforcing any other
rights of the Lender against the Mortgagor or any endorser of the Loan Documents
or any Guarantor, or against the Premises); (c) exercise any and all of the
rights and remedies of a secured party under the Uniform Commercial Code; (d)
appoint or cause to be appointed a receiver or custodian of the Premises, with
or without commencing foreclosure of this Mortgage or suit on the Loan Documents
or to otherwise collect on the Obligations, and without regard for the adequacy
of the security for the Obligations, and such receiver shall be authorized to
enter upon and take and maintain full control of the Premises in order to
perform all acts necessary or appropriate for the operation and maintenance
thereof, including but not limited to, the execution, cancellation or
modification of leases, the collection of all rents and revenues of the
Premises, the making of repairs to the Premises and the execution or termination
of contracts providing for the management or

                                       13
<PAGE>

maintenance of the Premises, all on such terms as are deemed best to protect the
security of this Mortgage; (e) foreclose upon this mortgage by judicial
proceeding or any other manner permitted by applicable law, and such rights
shall not be exhausted until all of the Premises shall have been sold or all
other Obligations satisfied; (f) take such other actions or proceedings as the
Lender deems necessary or advisable to collect or enforce or to protect its
interest in the Premises and the Obligations; and (g) exercise of such other
rights and remedies as may be available to a mortgagee/secured party under
applicable law. Such options shall continue until all such Events of Default
have been cured, and may be exercised individually, sequentially or in concert,
all such remedies being cumulative, the exercise of one not being deemed a
waiver of any of the others or a cure of any Event of Default. Furthermore, if
the Lender commences any action to foreclose this Mortgage, the Lender may
postpone such foreclosure sale of all or any parcel of the Premises by public
announcement at the time and place of any previously scheduled sale, and the
Lender shall be entitled to postpone, adjourn and reschedule and/or cancel any
such sale in its sole discretion without prejudice, and without it being deemed
commercially unreasonable. Lender shall be entitled to collect all expenses
incurred in pursuing any right or remedy following an Event of Default,
including, but not limited to, reasonable attorneys' fees (which fees shall be
allowed and paid as part of the decree of judgment) and costs of title evidence.
The proceeds of any such sale shall be applied in the following order: (i) all
costs and expenses of the sale, including reasonable attorneys' fees, title
examination costs, advertising costs, auctioneer's costs and the like; (ii) to
all unpaid interest secured by this Mortgage; (iii) to all unpaid principal and
other unpaid sums secured by this Mortgage; and (iv) the excess, if any, to the
person or persons legally entitled thereto.

          7.5  Rents; Mortgagee in Possession; Etc.  Upon the occurrence of any
               -----------------------------------
Event of Default, the Lender, without in any way waiving any rights under this
Article 7, may at its option, without notice, and without regard to the adequacy
of the security for the indebtedness secured hereby, either in person or by
agent, with or without bringing any action or proceeding to foreclose this
Mortgage, bringing any suit on the Loan Documents or otherwise to collect the
Obligations, or by a receiver appointed by a court, take possession of the
Premises, hold, manage, lease and operate the same on such terms and for such
period of time as the Lender may deem proper and, either with or without taking
possession of the Premises, and with or without initiating foreclosure
proceedings, in the name of the Mortgagor or in its own name as Assignee,
demand, sue for or otherwise collect and receive all rents, income and profits
of the Premises, including those past due and unpaid.  All rents collected by
the Lender shall be applied first to the payment of costs of management of the
Premises and collection of rents, including, but not limited to, reasonable
attorneys' fees, and then to the sum secured by this Mortgage.  The Lender shall
be liable to account only for those rents actually received, and shall not be
liable for any mismanagement or other conduct in connection with its possession,
management or operation of the Premises, except for its willful misconduct or
gross negligence.  If the rents of the Premises are not sufficient to meet the
costs, if any, of taking control of, operating and managing the Premises and
collecting the rents, any funds expended by the Lender for such purposes shall
become indebtedness of the Mortgagor to the Lender secured by this Mortgage as
if originally included in the Obligations.  Such amounts shall be payable upon
notice from the Lender to the Mortgagor requesting payment thereof and shall
bear interest from the date of disbursement at the Highest Lawful Rate, unless
payment of interest at such rate would be contrary to applicable law, in which
event such amounts shall bear interest at the highest rate which may be
collected

                                       14
<PAGE>

from the Mortgagor under applicable law. In the event the Lender elects to seek
the appointment of a receiver for the Premises following an Event of Default,
the Mortgagor hereby expressly consents to the appointment of a receiver. The
receiver shall be entitled to receive a reasonable fee for so managing the
Property.

          7.6  No Waiver by the Lender.  The failure of the Lender to exercise
               -----------------------
any right or remedy or option provided for herein or under applicable law shall
not be deemed to be a waiver of any of the covenants or obligations secured by
this Mortgage or otherwise.  No sale of all or any of the Premises, no
forbearance on the part of the Lender, no release or partial release of any of
the Premises, and no extension, whether oral or in writing, of the time for the
payment of the whole or any part of the Obligations or any other indulgence
given by the Lender to the Mortgagor, shall operate to release or in any manner
affect the lien of the Mortgage with respect to those portions of the Premises
not released pursuant to Section 8.7 or the original liability of the Mortgagor,
notice of any such extensions or indulgences being hereby waived by the
Mortgagor.  Any entering upon and taking and maintaining of control of the
Premises by the Lender, the receiver or any agent thereof, and any application
of rents as provided herein shall not cure or waive any default hereunder or
invalidate any other right or remedy of the Lender under applicable law or
provided herein.

          7.7  Mortgagor's Waiver of Certain Rights.  The Mortgagor hereby
               ------------------------------------
waives, to the fullest extent permitted by law, (i) the benefit of all laws now
existing or that hereafter may be enacted providing for any appraisement before
sale of any portion of the Premises, and (ii) the benefit of all laws that
hereafter may be enacted in any way extending the time for the enforcement or
the collection of the Obligations or creating or extending a period of
redemption from any sale made in collecting the Obligations.  The Lender shall
not be required to marshal the Premises, the Leases, rents, issues and profits
assigned by the Assignment, or any other Security in any particular order.  The
Mortgagor hereby covenants and agrees that it will not enforce or otherwise
exercise any rights of reimbursement, subrogation, contribution or other similar
rights against any co-obligor obligated on or with respect to any Obligations or
granting any security prior to the payment in full of the Obligations.

                            8.  GENERAL PROVISIONS.
                                ------------------

          8.1  Lender's Expenses.  Any and all costs and expenses reasonably
               -----------------
incurred by the Lender in connection with performing (but not making),
protecting or collecting the Obligations and the Loan, including, without
limitation, reasonable attorneys' fees, shall be paid by the Mortgagor on the
demand of the Lender and if not so paid on demand shall become part of the
Obligations and accrue interest at the default rate set forth in the Loan
Documents.  Without limiting the generality of the preceding sentence:  (a) if
the Lender is made a party defendant to any litigation concerning this Mortgage
or the Premises, then the Mortgagor shall indemnify, defend and hold the Lender
harmless from and against all claims, liabilities, judgments, costs and expenses
by reason of said litigation, including reasonable attorneys' fees and expenses
incurred by the Lender in any such litigation, whether or not any such
litigation is prosecuted to judgment; or (b) if the Mortgagor breaches any
provision of this Mortgage or any of the other Loan Documents, the Lender may
employ an attorney or attorneys to protect its rights hereunder or thereunder,
and in the event of such employment following any breach by the

                                       15
<PAGE>

Mortgagor, then the Mortgagor shall pay the reasonable attorneys' fees and
expenses incurred by the Lender, whether or not an action is actually commenced
against the Mortgagor by reason of such breach or whether or not any such
action, once commenced, is prosecuted to judgment.

          8.2  Construction, etc.  The interpretation of the provisions of this
               ------------------
Mortgage and any of the other Loan Documents shall not be construed against any
party hereto based upon the fact that such party may have drafted or caused to
be drafted such provision.  The Mortgagor hereby acknowledges that it has been
represented by independent counsel of its own selection and, notwithstanding
that counsel for the Lender has prepared the first draft of this Mortgage and
the other Loan Documents, the Mortgagor hereby agrees that the same shall not be
construed against the Lender in the event of any ambiguity, in that each party's
counsel participated in the negotiation and codification of this Mortgage and
the other Loan Documents.  Further, no prior draft or version of this Mortgage
or any other Loan Document may be used or relied upon to interpret or construe
any term or provision, or the absence of any term or provision, hereof or
thereof.  This instrument, together with all other Loan Documents, merges all
prior and contemporaneous agreements, understandings, warranties and
representations of the parties hereto.

          8.3  Notices.  All notices and other communications required or
               -------
permitted to be given hereunder shall be made in the manner and to the addresses
set forth in the Loan Agreement.

          8.4  Amendments.  This Mortgage may not be waived, changed or
               ----------
discharged orally, but only by an agreement in writing, signed by all parties,
and any attempted oral waiver, change or discharge of any provision of this
Mortgage shall have no force or effect.

          8.5  Waiver of Statute of Limitations.  The Mortgagor hereby waives
               --------------------------------
the right to assert any statute of limitations as a bar to the enforcement of
the lien of this Mortgage or any other provision herein, or to any action
brought to enforce the Loan Documents or any of the other Obligations secured by
this Mortgage.

          8.6  Miscellaneous.  Section captions are not a part hereof.  The
               -------------
invalidity of any provisions of this Mortgage, as determined by a court of
competent jurisdiction, shall in no way affect the validity of any other
provisions hereof.  This Mortgage shall be interpreted in accordance with and
governed by the laws of The State of Delaware.  This Mortgage shall be binding
upon and inure to the benefit of the respective permitted successors and assigns
of the parties hereto.  The term "Mortgagor", together with any pronoun
referring thereto, shall include the singular, plural, masculine, feminine and
neuter, as the context may require; and if more than one person constitutes any
of such parties, the obligations of such persons shall be joint and several.

          8.7  Defeasance.  Upon full payment and performance of all Obligations
               ----------
in accordance with the terms of the Loan Documents, Lender shall, at Mortgagor's
request and expense, release this Mortgage of record, whereupon this Mortgage
shall have no further force or effect, except as expressly provided herein.
Following any conveyance, sale, assignment, transfer or disposal of ownership or
control of all of Mortgagor's interest in the Premises to which Lender consents
in accordance with Section 3.2(b), Lender shall release this Mortgage of

                                       16
<PAGE>

record at Morgagor's cost. No release of this Mortgage or the lien hereof shall
be valid unless executed by Lender.

          8.8  Conflict.  In the event of any conflict between the terms,
               --------
provisions or conditions of this Mortgage and the terms, provisions or
conditions of the Loan Agreement, the terms, provisions or conditions of the
Loan Agreement shall govern.

     This Mortgage has been executed and delivered for fair and adequate
consideration, and does not constitute a fraudulent conveyance under applicable
law.

     If any provision hereof or the application thereof to any person or
circumstance should be invalid or unenforceable to any extent, the remainder
hereof, or the application of such provision to persons or circumstances other
than those as to which it is held invalid or unenforceable, shall not be
affected thereby, and each provision hereof shall be valid and enforced to the
fullest extent permitted by law.

     This Mortgage may not be amended orally and time is of the essence in
connection with each and every obligation of the Mortgagor hereunder.

          8.9  No Recourse.  No shareholder, director, officer, agent,
               -----------
affiliate, or employee of the Mortgagor shall have any personal liability under
this Mortgage and no judgment shall be sought, obtained or enforced against any
such person or entity, except with respect to Costs alleged to be based on the
willful misconduct or gross negligence of such party.

                                       17
<PAGE>

     IN WITNESS WHEREOF, this instrument has been executed as a Delaware
instrument under seal as of the day and year first above written.

WITNESS:                                   MORTGAGOR:

                                           HOLOGIC, INC.

 /s/ Matthew Gilman                        By: /s/ Glenn P. Muir          (Seal)
 --------------------------------              ---------------------------
                                               Name:    Glenn P. Muir
                                               Title: Chief Financial Officer

                         _____________________________

 Suffolk___________, ss.                                      September 20, 2001
                                                                        --

     Then personally appeared the above-named Glenn P. Muir, the  Chief
                                                                  -----
Financial Officer of Hologic, Inc., and acknowledged the foregoing instrument to
-----------------
be his free act and deed and the free act and deed of Hologic, Inc., before me,

                           /s/ Linda M. Connolly
                           ------------------------------------
                           Notary Public
                           My Commission Expires:  9/15/2006
                                                 --------------

                          Signature Page to Mortgage

                                       18<PAGE>

                                                                 EXHIBIT 10.29

                                FIRST AMENDMENT
                        TO LOAN AND SECURITY AGREEMENT
                        ------------------------------

     THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this "First
                                                                -----
Amendment") is entered into as of December 8, 2001 by and among, on the one
---------
hand, HOLOGIC, INC., a Delaware corporation ("Parent"), FLUOROSCAN IMAGING
                                              ------
SYSTEMS, INC., a Delaware corporation and a wholly-owned subsidiary of Parent
("FluoroScan"), and DIRECT RADIOGRAPHY CORP., a Delaware corporation and a
  ----------
wholly-owned subsidiary of Parent ("DRC" and, collectively with the Parent and
                                    ---
FluoroScan, jointly, severally and jointly and severally, the "Borrowers" and
                                                               ---------
each a "Borrower"), and, on the other hand, the financial institutions from time
        --------
to time party to the Loan Agreement referred to below (collectively, the
"Lenders" and each individually, a "Lender"), and FOOTHILL CAPITAL CORPORATION,
 -------                            ------
as agent for the Lenders under the Loan Agreement (in such capacity, the
"Agent").
 -----

                                   RECITALS
                                   --------

     As of September 21, 2001, the Borrowers and the Agent entered into a Loan
and Security Agreement (as amended by and through the date hereof and as further
amended, restated, supplemented or otherwise modified from time to time, the
"Loan Agreement").  The Borrowers have requested certain amendments to the Loan
 --------------
Agreement and a consent thereunder.  The Lenders and the Agent are willing to
amend the Loan Agreement and grant such consent as requested by the Borrowers on
the terms and conditions hereinafter set forth.

     NOW, THEREFORE, in consideration of the foregoing and the mutual covenants
herein contained, and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties signatory hereto agree
as follows.

     1.   Definitions.  Capitalized terms used but not otherwise defined herein
          -----------
shall have the respective meanings ascribed to such terms in the Loan Agreement.

     2.   Amendments to the Loan Agreement.
          --------------------------------

     (a)  Section 2.1 of the Loan Agreement is hereby amended as follows:
          -----------

          (i)  first, by adding the following paragraph at the end of subsection
               -----
     (a) thereof:

               "Until Parent delivers evidence satisfactory to Agent in the
          Agent's Permitted Discretion that Borrowers have received at least
          $10,000,000 in Additional Investment Proceeds, Advances shall not
          exceed $15,000,000."

          (ii) second, by inserting a new subsection (c) thereof, which
               ------
     subsection (c) shall read in full as follows:

               "(c)  Without limiting the generality of Section 2.1(b) above,
                                                        --------------
          until Parent delivers evidence satisfactory to Agent in the Agent's
          Permitted Discretion
<PAGE>

          that Borrowers have received at least $10,000,000 in Additional
          Investment Proceeds, Agent may establish an additional $8,500,000
          reserve against the Borrowing Base."

          (iii)  and third, by redesignating subsections (c), (d), (e) and (f)
                     -----
     of such Section 2.1 as subsections (d), (e), (f) and (g).
             -----------

     (b)  Section 2.11 of the Loan Agreement is hereby amended first by deleting
          ------------                                         -----
the word "and" at the end of subsection (b) of such section, second by deleting
                                                             ------
the period at the end of subsection (c) of such section and inserting in lieu
thereof the words "; and", and third by adding a new subsection (d) to such
                               -----
section, which new subsection (d) shall read in full as follows:

                 "(d)  Each Investment Fee Period, commencing with the
          Investment Fee Period ending April 30, 2002, unless Borrowers shall
          have delivered evidence satisfactory to Agent in the Agent's Permitted
          Discretion that Borrowers have received at least $10,000,000 in
          Additional Investment Proceeds on or before the last Business Day of
          such Investment Fee Period, Borrowers shall pay to Agent a fee of
          $50,000, which fee shall be due and payable on the last Business Day
          of such Investment Fee Period. For the purposes hereof, "Investment
          Fee Period" shall mean a three month period ending on the last
          Business Day of the calendar months of April, July, October or
          January, as applicable, of each calendar year."

     (c)  Section 6.16 of the Loan Agreement is hereby amended first by deleting
          ------------                                         -----
subsection (a) thereof in its entirety and second by redesignating subsection
                                           ------
(b) thereof as subsection (a).

     (d)  Section 7.16 of the Loan Agreement is hereby deleted in its entirety.
          ------------

     (e)  Schedule 7.20 of the Loan Agreement is hereby amended by deleting such
          -------------
Schedule in its entirety and inserting Schedule 7.20 attached hereto in lieu
thereof.

     3.   Consent.  The Agent hereby consents to the closing of Parent's Hologic
          -------
Systems Division manufacturing facility in Littleton, Massachusetts so long as
such closing is conducted in a manner consistent with the summary thereof
previously provided by Parent to the Agent and the costs associated with such
closing incurred by Borrowers after September 29, 2001 (excluding those costs
incurred in connection with the operation of such facility prior to such
closing) do not exceed $2,000,000.

     4.   Conditions Precedent to First Amendment.  The satisfaction of each of
          ---------------------------------------
the following, unless waived or deferred by the Agent, in its sole discretion,
shall constitute conditions precedent to the effectiveness of this First
Amendment and each and every provision hereof:

     (a)  The representations and warranties in this First Amendment, the Loan
Agreement as amended by this First Amendment, and the other Loan Documents shall
be true and correct in all material respects on and as of the date hereof, as
though made on such date (except to the extent that such representations and
warranties relate solely to an earlier date);

                                       2
<PAGE>

     (b)  No Event of Default shall have occurred and be continuing on the date
hereof, nor shall result from the consummation of the transactions, including,
without limitation, the Littleton Closing, contemplated herein;

     (c)  No injunction, writ, restraining order, or other order of any nature
prohibiting, directly or indirectly, the consummation of the transactions
contemplated herein shall have been issued and remain in force by any
Governmental Authority against the Borrowers or the Agent;

     (d)  The Agent shall have received a first amendment fee of $50,000 from
the Borrowers; and

     (e)  The Agent shall have received payment in full of its out-of pocket
expenses (including reasonable attorneys' fees and expenses) incurred in
connection with the Loan Agreement and this First Amendment.

     5.   Representations and Warranties.  Each Borrower hereby represents and
          ------------------------------
warrants to the Agent that (a) the execution, delivery, and performance of this
First Amendment and of the Loan Agreement are within such Borrower's corporate
powers, have been duly authorized by all necessary corporate action, and are not
in contravention of any law, rule, or regulation, or any order, judgment,
decree, writ, injunction, or award of any arbitrator, court, or governmental
authority, or of the terms of its charter or bylaws, or of any contract or
undertaking to which it is a party or by which any of its properties may be
bound or affected, (b) this First Amendment and the Loan Agreement constitute
such Borrower's legal, valid, and binding obligation, enforceable against
Borrower in accordance with its terms, and (c) this First Amendment has been
duly executed and delivered by such Borrower.

     6.   Choice of Law.  The validity of this First Amendment, its
          -------------
construction, interpretation and enforcement, and the rights of the parties
hereunder, shall be determined under, governed by, and construed in accordance
with the laws of The Commonwealth of Massachusetts.

     7.   Counterparts; Telefacsimile Execution.  This First Amendment may be
          -------------------------------------
executed in any number of counterparts and by different parties and separate
counterparts, each of which when so executed and delivered, shall be deemed an
original, and all of which, when taken together, shall constitute one and the
same instrument. Delivery of an executed counterpart of a signature page to this
First Amendment by telefacsimile shall be as effective as delivery of a manually
executed counterpart of this First Amendment. Any party delivering an executed
counterpart of this First Amendment by telefacsimile also shall deliver a
manually executed counterpart of this First Amendment but the failure to deliver
a manually executed counterpart shall not affect the validity, enforceability,
and binding effect of this First Amendment.

     8.   Effect on Loan Agreement and Other Loan Documents.  The Loan
          -------------------------------------------------
Agreement, as amended hereby, and the other Loan Documents shall be and remain
in full force and effect in accordance with their respective terms and hereby
are ratified and confirmed in all respects. The execution, delivery, and
performance of this First Amendment shall not operate as a waiver of or, except
as expressly set forth herein, as an amendment of, any right, power, or remedy
of the

                                       3
<PAGE>

Agent under the Loan Agreement or any other Loan Document, as in effect prior to
the date hereof.

     9.   Further Assurances.  The Borrowers shall execute and deliver all
          ------------------
agreements, documents, and instruments, in form and substance satisfactory to
Agent, and take all actions as the Agent may reasonably request from time to
time, to perfect and maintain the perfection and priority of the security
interest in the Collateral held by the Agent and to fully consummate the
transactions contemplated under this First Amendment and the Loan Agreement, as
amended by this First Amendment.

     10.  Miscellaneous.
          -------------

     (a)  Upon and after the effectiveness of this First Amendment, each
reference in the Loan Agreement to "this Agreement", "hereunder", "herein",
"hereof" or words of like import referring to the Loan Agreement, and each
reference in the other Loan Documents to "the Loan Agreement", "thereunder",
"therein", "thereof" or words of like import referring to the Loan Agreement,
shall mean and be a reference to the Loan Agreement as modified and amended
hereby.

     (b)  The Loan Agreement and all other Loan Documents, are and shall
continue to be in full force and effect and are hereby in all respects ratified
and confirmed and shall constitute the legal, valid, binding and enforceable
obligations of the Borrowers to the Agent.

                  [Signatures appear on the following page.]

                                       4
<PAGE>

     IN WITNESS WHEREOF, the parties hereto have caused this First Amendment to
Loan and Security Agreement to be executed as of the date first above written.

                                    BORROWERS:
                                    ---------

                                    HOLOGIC, INC.,
                                    as Borrower and Administrative Borrower

                                    By: /s/ Glenn P. Muir
                                       ----------------------------------------
                                       Glenn P. Muir, Chief Financial Officer

                                    FLUOROSCAN IMAGING SYSTEMS, INC.,
                                    as Borrower

                                    By: /s/ Glenn P. Muir
                                       ----------------------------------------
                                       Glenn P. Muir, Vice President-Finance

                                    DIRECT RADIOGRAPHY CORP.,
                                    as Borrower

                                    By: /s/ Glenn P. Muir
                                       ----------------------------------------
                                       Glenn P. Muir, Vice President-Finance

                                    AGENT AND REQUIRED LENDERS:
                                    --------------------------

                                    FOOTHILL CAPITAL CORPORATION,
                                    as Agent and as sole Lender

                                    By: /s/ Andrew T. Furlong
                                       ----------------------------------------
                                       Andrew T. Furlong, Vice President

     The undersigned hereby acknowledges this First Amendment and ratifies and
confirms its obligations under the Guaranty and Security Agreement and any other
Loan Document to which it is a party.

X-RAY TECHNOLOGY CORP.

By: /s/ Glenn P. Muir
    --------------------------------------
    Glenn P. Muir, Vice President-Finance

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