Document:

EX-10.14

 Exhibit 10.14 
  

			
	

	 	 WaVe Life Sciences, Pte. Ltd.

419 Western Ave Boston, MA 02135

Tel: 617 206 4830 Fax 617 206 4831

 July 2nd, 2014 
 Dear
Dr. Vargeese: 
 It is a pleasure to offer you a position as SVP, Head of Drug Discovery with Wave Life Sciences, Pte. Ltd. You will be reporting to
Dr. Paul Bolno, President and CEO of the company. We believe that you will be a valuable member to our company and will make an important contribution to the achievement of our goals. The details of your employment are outlined below. 

Effective Date 
 Your first day of employment will
be mutually agreed upon, and is expected to be no later than August 18th, 2014. 
 Compensation 

The annually salary will be $285,000 (Two Hundred and Eighty Five Thousand Dollars) and will be paid in accordance with our normal payroll procedures. In
addition, upon the establishment of the employee option pool and final approval of the board, you will be entitled to 1.5% of this newly issued option pool. Options will have a 4-year vesting period with vesting occurring on monthly intervals
starting from date of hire. 
 Variable Pay/Bonus 

Your position is eligible to participate in a discretionary variable, performance based pay bonus program up to 25% of your base salary subject to withholding
and other applicable taxes, and paid in accordance with company’s usual payroll procedures. As per our agreement, you will receive $15,000 (Fifteen Thousand dollars) upon your commencement date, provided, however, that you sign and return our
Employee Guide and our Confidentiality and Invention Disclosure and Assignment Agreement, all of which is a condition to your employment with us. 

Benefits 
 You will be eligible to participate in
the Company’s group benefits program beginning the first day of the month following your hire date unless your hire date is the first work day of the month. These coverage, waiting periods, and rates of coverage are subject to change, as
determined by the Company, and are not to be considered a contractual agreement with the employee. The benefits are as follows: 
  

	 	•	 	Medical, dental, vision, and pharmaceutical coverage’s are provided at no charge to the employee and available to immediate family members at a fee. 

 

	 	•	 	Short term and long term disability insurance is company paid for the employee. 

 Work Authorization 

All new employees are required to complete the Immigration and Naturalization Form (1-9) within the first three (3) days of employment with the Company.
These documents verify your identity and right to work in the United States. 
 If you are in need of a work visa please notify Dr. Paul Balno at the time
of job acceptance. 
 At Will Employment 
 Your
employment with WaVe Life Sciences, Pte. Ltd. is considered at-will employment. At-will employment means that the employer or employee may terminate the employment relationship, at any time with two week advance notice, with or without cause.
This offer letter does not constitute an employment contract nor guarantee permanent employment. The Company reserves the right, at its’ sole discretion, to modify your compensation, benefits, and other terms or conditions of employment,
at any time. 
 Confidentiality/Non-Disclosure 

As a condition of employment, you are required to execute the company’s Confidentiality Agreement which will be provided to you at New Hire Orientation.

 Entire Agreement 
 This letter and the above
referenced Confidentiality Agreement contain all of the terms of your employment with WaVe Life Sciences, Ptd. Ltd. and supersedes any prior understandings or agreement, whether oral or in writing. This letter and Confidentiality Agreement can only
be modified in writing and with express agreement by the Company. 
 We appreciate your interest in WaVe Life Sciences, Ptd. Ltd., and look forward to
rewarding working relationship. Please contact me with any questions. 
 Sincerely, 

/s/ Paul Bolno 
 Dr. Paul Bolno 

President and CEO 
 I have read and understand the information
stated above and accept this offer of employment. 
  

			
	 /s/ Chandra Vargeese
	  	 July 18th, 2014

	Name Chandra Vargeese, Ph.D.	  	Date

 Upon acceptance of this employment offer, fax a signed copy of this letter to Dr. Paul BolnoEX-10.15

 Exhibit 10.15 
  

			
	

	 	 WaVe Life Sciences, Pte. Ltd.

419 Western Ave Boston, MA 02135

Tel: 617 206 4830 Fax 617 206 4831

 March 10th, 2014 
 Dear
Dr. Christopher Francis: 
 It is a pleasure to offer you a position as VP Business Development with Wave Life Sciences. You will be reporting to
Dr. Paul Bolno, President and CEO of the company. We believe that you will be a valuable addition to our new company and will make an important contribution to the achievement of our goals. The details of your employment are outlined below.

 Effective Date 
 Your first day of employment
will be mutually agreed upon, and is expected to be no later than April 31st, 2014. 
 Compensation 

Your position is classified as exempt. The annual salary will be $185,000 (One Hundred and Eighty Five Thousand) and will be paid on a semi-monthly basis
subject to withholding and other applicable taxes, and paid in accordance with the Company’s usual payroll procedures. In addition, upon the establishment of the employee option pool and final approval of the board, you will be entitled to 1%
of this newly issued option pool. Options will have a 4-year vesting period with vesting occurring on monthly intervals starting from date of hire. 

Variable Pay/Bonus 
 Your position is eligible to
participate in a discretionary, variable, performance-based pay bonus program up to 25% of base pay subject to withholding and other applicable taxes, and paid in accordance with the Company’s usual payroll procedures. In addition and based on
performance you may be entitled to additional stock options; subject to final board approval. 

			
	

	 	 WaVe Life Sciences, Pte. Ltd.

419 Western Ave Boston, MA 02135

Tel: 617 206 4830 Fax 617 206 4831

 Benefits 
 You will
be eligible to participate in the Company’s group benefits program beginning the first day of the month following your hire date, unless your hire date is the first work day of the month. The benefits program, including waiting periods and
rates of coverage, is subject to change, as determined by the Company, and is not to be considered a contractual agreement with the employee. The benefits are as follows: 
  

	 	•	 	Medical, dental, vision, and pharmaceutical coverage is provided at no charge to the employee and available to immediate family members at a discounted fee. 

 

	 	•	 	Life insurance is paid at one time (1x) the employee’s annual salary to a maximum of $50K; additional coverage is available at a fee. 

 

	 	•	 	Short term and long term disability insurance is Company paid for the employee. 

 Work Authorization

 All new employees are required to complete the Immigration and Naturalization Form (I-9) within the first three (3) days of employment with
the Company. These documents verify your identity and right to work in the United States. 
 At Will Employment 

Your employment with Wave is considered at-will employment. At-will employment means that the employer or employee may terminate the employment relationship,
at any time with a two-week advance notice, with or without cause. This offer letter does not constitute an employment contract nor guarantee permanent employment. The Company reserves the right, at its sole discretion, to modify your
compensation, benefits, and other terms or conditions of employment, at any time. 
 Confidentiality/Non-Disclosure 

As a condition of employment, you are required to execute the Company’s Confidentiality Agreement that will be provided to you at New Hire Orientation.

 Entire Agreement 
 This letter and the above
referenced Confidentiality Agreement contain all of the terms of your employment with Wave Life Sciences, and supersede any prior understandings or agreements, whether oral or in writing. This letter and the Confidentiality Agreement can only be
modified in writing and with express agreement by the Company. 

			
	

	 	 WaVe Life Sciences, Pte. Ltd.

419 Western Ave Boston, MA 02135

Tel: 617 206 4830 Fax 617 206 4831

 We appreciate your interest in Wave and look forward to a rewarding working relationship. Please contact me with any
questions. 
 Sincerely, 
 /s/ Paul Bolno 

Dr. Paul Bolno 
 President and CEO; Wave Life Sciences 

I have read and understand the information stated above and accept this offer of employment. 

 

			
	 /s/ Christopher Francis
	  	 March 20th, 2014

	Name: Christopher Francis	  	Date

 Upon acceptance of this employment offer, fax a signed copy of this letter to Dr. Paul Bolno.EX-10.16

 Exhibit 10.16 

ONTORII, INC. 

CONSULTING AGREEMENT 

This Consulting Agreement (this “Agreement”) is made and entered into effective as of the 1st of April, 2012 (the “Effective Date”) by and between Ontorii, Inc., a Delaware corporation with its principal place of business at 419 Western Avenue, Boston, Mass. 02135
(the “Company”), and Greg Verdine an individual with his principal place of business at [Address] (“Consultant”) (each herein referred to individually as a “Party,” or
collectively as the “Parties”). 
 The Company desires to retain Consultant as an independent contractor to perform
consulting services for the Company, and Consultant is willing to perform such services, on the terms described below. In consideration of the mutual promises contained herein, the Parties agree as follows: 

 

	 	1.	Services and Compensation 

 Consultant shall perform the services described in Exhibit
A (the “Services”) for the Company (or its designee), and the Company agrees to pay Consultant the compensation described in Exhibit A for Consultant’s performance of
the Services. 
  

	 	2.	Applicability to Past Activities 

 Consultant agrees that if and to the extent that
Consultant provided any services or made efforts on behalf of or for the benefit of Company, or related to the current or prospective business of Company in anticipation of Consultant’s involvement with the Company, that would have been
“Services” if performed during the term of this Agreement (the “Prior Consulting Period”) and to the extent that during the Prior Consulting Period: (i) Consultant received access to any information from or on
behalf of Company that would have been “Confidential Information” (as defined below) if Consultant received access to such information during the term of this Agreement; or (ii) Consultant conceived, created, authored, invented,
developed or reduced to practice any item (including any intellectual property rights with respect thereto) on behalf of or for the benefit of Company, or related to the current or prospective business of Company in anticipation of Consultant’s
involvement with Company, that would have been an “Invention” (as defined below) if conceived, created, authored, invented, developed or reduced to practice during the term of this Agreement; then any such information shall be deemed
“Confidential Information” hereunder and any such item shall be deemed an “Invention” hereunder, and this Agreement shall apply to such activities, information or item as if disclosed, conceived, created, authored, invented,
developed or reduced to practice during the term of this Agreement. Consultant further acknowledges that Consultant has been fully compensated for all Services provided during any such Prior Consulting Period. 

 

	 	3.	Confidentiality 

 A. Definition of Confidential Information.
“Confidential Information” means any non-public information that relates to the actual or identified to Consultant as reasonably anticipated business and/or products, research or development of the Company, its affiliates or
subsidiaries, or to the Company’s, its affiliates’ or subsidiaries’ technical data, trade secrets, or know-how, including, but not limited to, research, product plans, or other information regarding the Company’s, its
affiliates’ or subsidiaries’ products or services and markets therefor, customer lists and customers (including, but not limited to, customers of the Company on whom Consultant called or with whom Consultant became acquainted during the
term of this Agreement), software, developments, inventions, processes, formulas, 

 
technology, designs, drawings, engineering, hardware configuration information, marketing, finances, and other business information disclosed to Consultant by the Company, its affiliates or
subsidiaries, either directly or indirectly, in writing, orally or by drawings or inspection of premises, parts, equipment, or other property of Company, its affiliates or subsidiaries. Notwithstanding the foregoing, Confidential Information shall
not include any such information which Consultant can establish (i) was publicly known or made generally available prior to the time of disclosure to Consultant; (ii) becomes publicly known or made generally available after disclosure to
Consultant through no wrongful action or inaction of Consultant; (iii) is in the rightful possession of Consultant, without violation of Consultant’s confidentiality obligations under this Agreement, at the time of disclosure as shown by
Consultant’s then-contemporaneous written records; (iv) becomes available to Consultant on a nonconfidential basis; or (v) was independently developed by Consultant without reference to the information provided to Consultant a by
Company, its affiliates and subsidiaries. In addition, Confidential Information shall not include information directly or indirectly generated by Consultant unless the information (i) is generated as a direct result of the performance of
Services by Consultant and (ii) is not directly or indirectly generated in the course of Consultant’s activities for Harvard University or for Third Rock Ventures, LLC. 

B. Nonuse and Nondisclosure. During and after the term of this Agreement, Consultant will hold in the strictest confidence, and
take all reasonable precautions to prevent any unauthorized use or disclosure of Confidential Information by Consultant, and Consultant will not (i) use the Confidential Information for any purpose whatsoever other than as necessary for the
performance of the Services on behalf of the Company, or (ii) disclose the Confidential Information to any third party without the prior written consent of an authorized representative of Company. Consultant may disclose
Confidential Information to the extent compelled by applicable law; provided however, prior to such disclosure, Consultant shall provide prior written notice to Company and, at Company’s sole expense, reasonably assist Company to
seek a protective order or such similar confidential protection as may be available under applicable law. Consultant agrees that no ownership of Confidential Information is conveyed to the Consultant. Without limiting the foregoing, Consultant shall
not use or disclose any Confidential Information to invent, author, make, develop, design, or otherwise enable others to invent, author, make, develop, or design identical or substantially similar designs as those developed under this Agreement for
any third party. Consultant agrees that Consultant’s obligations under this Section 3.B shall continue for three (3) years after the termination of this Agreement. 

C. Other Client Confidential Information. Consultant agrees that Consultant will not improperly use, disclose, or induce the
Company to use any proprietary information or trade secrets of any former or concurrent employer of Consultant or other person or entity with which Consultant has an obligation to keep in confidence. Consultant also agrees that Consultant will use
good faith efforts to not bring onto the Company’s premises or transfer onto the Company’s technology systems any unpublished document, proprietary information, or trade secrets belonging to any third party unless disclosure to, and use
by, the Company has been consented to in writing by such third party. 
 D. Third Party Confidential Information. Provided
that third party Confidential Information is specifically identified to Consultant in writing as constituting third party Confidential Information prior to or contemporaneous with its disclosure to Consultant, Consultant recognizes that the Company
has received and in the future will receive from third parties their confidential or proprietary information subject to a duty on the Company’s part to maintain the confidentiality of such information and to use it only for certain limited
purposes. Consultant agrees that at all times during the term of this Agreement and for three (3) years thereafter, Consultant owes the Company and such third parties a duty to hold all such third party Confidential Information in the strictest
confidence and not to use it or disclose it to any person, firm, corporation, or other third party except as necessary in carrying out the Services for the Company consistent with the Company’s agreement with such third party. 

  
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	 	4.	Ownership 

 A. Assignment of Inventions. Consultant agrees that all right,
title, and interest in and to any copyrightable material, notes, records, drawings, designs, inventions, improvements, developments, discoveries and trade secrets conceived, discovered, authored, invented, developed or reduced to practice by
Consultant, solely or in collaboration with others, during the term of this Agreement and arising out of, or in connection with, performing the Services under this Agreement and any copyrights, patents, trade secrets, mask work rights or other
intellectual property rights relating to the foregoing (collectively, “Inventions”), are the sole property of the Company. However, the term Inventions excludes such materials, ideas and knowledge generated in the course of
Consultant’s activities for Harvard University and for Third Rock Ventures, LLC. Consultant also agrees to use good faith efforts to promptly make full written disclosure to the Company of any Inventions and to deliver and assign (or assist in
assigning) and hereby irrevocably assigns fully to the Company all right, title and interest in and to the Inventions. 
 B.
Pre-Existing Materials. Subject to Section 4.A, Consultant agrees that if, in the course of performing the Services, Consultant incorporates into any Invention or utilizes in the performance of the Services any pre-existing
invention, discovery, original works of authorship, development, improvements, trade secret, concept, or other proprietary information or intellectual property right owned by Consultant or in which Consultant has an interest (“Prior
Inventions”), (i) Consultant will provide the Company with prior written notice and (ii) the Company is hereby granted a nonexclusive, royalty-free, perpetual, irrevocable, transferable, worldwide license (with the right to
grant and authorize sublicenses) to make, have made, use, import, offer for sale, sell, reproduce, distribute, modify, adapt, prepare derivative works of, display, perform, and otherwise exploit such Prior Inventions, without restriction, including,
without limitation, as part of or in connection with Inventions, and to practice any method related thereto. Consultant will not incorporate any invention, improvement, development, concept, discovery, work of authorship or other proprietary
information which is known to Consultant to be owned by any third party into any Invention without Company’s prior written permission, including without limitation any free software or open source software. 

C. Moral Rights. Any assignment to the Company of Inventions includes all rights of attribution, paternity, integrity,
modification, disclosure and withdrawal, and any other rights throughout the world that may be known as or referred to as “moral rights,” “artist’s rights,” “droit moral,” or the like (collectively,
“Moral Rights”). To the extent that Moral Rights cannot be assigned under applicable law, Consultant hereby waives and agrees not to enforce any and all Moral Rights, including, without limitation, any limitation on
subsequent modification, to the extent permitted under applicable law. 
 D. Maintenance of Records. Consultant agrees to use
good faith efforts to keep and maintain adequate, current, accurate, and authentic written records of all Inventions made by Consultant (solely or jointly with others) during the term of the Agreement, and for a period of three (3) years thereafter.
The records will be in the form of notes, sketches, drawings, electronic files, reports, or any other format that is customary in the industry and/or otherwise reasonably specified by the Company. Such records are and remain the sole property of the
Company at all times and upon Company’s request, Consultant shall deliver (or cause to be delivered) the same. 
 E. Further
Assurances. Consultant agrees to assist Company, or its designee, at the Company’s expense, in every proper way to secure the Company’s rights in Inventions in any and all countries, including the disclosure to the Company of all
pertinent information and data with respect thereto, the execution of all applications, specifications, oaths, assignments and all other instruments that the Company may deem necessary in order to apply for, register, obtain, maintain, defend, and
enforce 

  
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such rights, and in order to deliver, assign and convey to the Company, its successors, assigns and nominees the sole and exclusive right, title, and interest in and to all Inventions and
testifying in a suit or other proceeding relating to such Inventions. Consultant further agrees that Consultant’s obligations under this Section 4.E shall continue after the termination of this Agreement. 

F. Attorney-in-Fact. Consultant agrees that, if the Company is unable because of Consultant’s unavailability, dissolution,
mental or physical incapacity, or for any other reason, to secure Consultant’s signature with respect to any Inventions, including, without limitation, for the purpose of applying for or pursuing any applications for any United States or
foreign patents or mask work or copyright registrations covering the Inventions assigned to the Company in Section 4.A, then Consultant hereby irrevocably designates and appoints the Company and its duly authorized officers and agents as
Consultant’s agent and attorney-in-fact, to act for and on Consultant’s behalf to execute and file any papers and oaths and to do all other lawfully permitted acts with respect to such Inventions to further the prosecution and issuance of
patents, copyright and mask work registrations with the same legal force and effect as if executed by Consultant. This power of attorney shall be deemed coupled with an interest, and shall be irrevocable. 

 

	 	5.	Conflicting Obligations 

 A. Consultant represents and warrants that Consultant has no
agreements, relationships, or commitments to any other person or entity that conflict with the provisions of this Agreement, Consultant’s obligations to the Company under this Agreement, and/or Consultant’s ability to perform the Services.
Consultant will not enter into any such conflicting agreement during the term of this Agreement. 
 B. In light of the unique and
specialized nature of Consultant’s services, Consultant shall not have the right to subcontract the performance of any Services other than to an entity which at the relevant time Consultant substantially owns or controls including, without
limitation, Verdyne Corporation, a Verdine family trust, or an LLC so long as Greg Verdine directly and personally renders all of the Services and Greg Verdine remains liable for all obligations of Consultant. 

 

	 	6.	Return of Company Materials 

 Upon the termination of this Agreement, or upon
Company’s earlier request, Consultant will immediately deliver to the Company, and will not keep in Consultant’s possession, recreate, or deliver to anyone else, any and all Company property, including, but not limited to, Confidential
Information, tangible embodiments of the Inventions, all devices and equipment belonging to the Company, all electronically-stored information and passwords to access such property, those records maintained pursuant to Section 4.D and any
reproductions of any of the foregoing items that Consultant may have in Consultant’s possession or control. 
  

	 	7.	Reports 

 Consultant agrees that Consultant will periodically keep the Company advised as
to Consultant’s progress in performing the Services under this Agreement. Consultant further agrees that Consultant will, as requested by the Company, prepare written reports with respect to such progress. The Company and Consultant agree that
the reasonable time expended in preparing such written reports will be considered time devoted to the performance of the Services. 

  
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	 	8.	Term and Termination 

 A. Term. The term of this Agreement will begin on
the Effective Date of this Agreement and will continue until the earlier of (i) final completion of the Services or (ii) termination as provided in Section 8.B. 

B. Termination. The Company or Consultant may terminate this Agreement upon giving the other Party fourteen (14) days prior
written notice of such termination pursuant to Section 14.G of this Agreement. 
 C. Survival. Upon any termination, all
rights and duties of the Company and Consultant toward each other shall cease except: 
 (1) The Company will pay, within thirty
(30) days after the effective date of termination, all amounts owing to Consultant for Services provided by Consultant through the termination date and related reimbursable expenses, if any, submitted in accordance with the Company’s
policies and in accordance with the provisions of Article 1 of this Agreement; and 
 (2) Article 3 (Confidentiality), Article 4
(Ownership), Section 5.B (Conflicting Obligations), Article 6 (Return of Company Materials), Article 8 (Term and Termination), Article 9 (Independent Contractor; Benefits), Article 10 (Indemnification), Article 11 (Nonsolicitation), Article 12
(Public Statements), Article 13 (Arbitration and Equitable Relief), and Article 14 (Miscellaneous) will survive termination or expiration of this Agreement in accordance with their terms. 

 

	 	9.	Independent Contractor; Benefits 

 A. Independent Contractor. It is the
express intention of the Company and Consultant that Consultant perform the Services as an independent contractor to the Company. Nothing in this Agreement shall in any way be construed to constitute Consultant as an agent, employee or
representative of the Company. Without limiting the generality of the foregoing, Consultant is not authorized to bind the Company to any liability or obligation or to represent that Consultant has any such authority. Consultant agrees to furnish all
tools and materials necessary to accomplish this Agreement and shall incur all expenses associated with performance, except as expressly provided in Exhibit A. Consultant acknowledges and agrees that Consultant is obligated to report as
income all compensation received by Consultant pursuant to this Agreement. Consultant agrees to and acknowledges the obligation to pay all self-employment and other taxes on such income. 

B. Benefits. The Company and Consultant agree that Consultant will receive no Company-sponsored benefits from the Company where
benefits include, but are not limited to, paid vacation, sick leave, medical insurance and 401k participation. If Consultant is reclassified by a state or federal agency or court as the Company’s employee, Consultant will become a reclassified
employee and will receive no benefits from the Company, except those mandated by state or federal law, even if by the terms of the Company’s benefit plans or programs of the Company in effect at the time of such reclassification, Consultant
would otherwise be eligible for such benefits. 
  

	 	10.	Indemnification 

 Consultant agrees to indemnify and hold harmless the Company and its
affiliates and their directors, officers and employees from and against all taxes, losses, damages, liabilities, costs and expenses, including reasonable attorneys’ fees and other legal expenses (but excluding attorneys’ fees and other
legal and accounting expenses regarding (ii) in this Article), arising directly or indirectly from or in 

  
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connection with (i) any negligent, reckless or intentionally wrongful act of Consultant or Consultant’s assistants, employees, contractors or agents, (ii) a determination by a
court or agency that the Consultant is not an independent contractor, (iii) any breach by the Consultant or Consultant’s assistants, employees, contractors or agents of any of the covenants contained in this Agreement and corresponding
Confidential Information and Invention Assignment Agreement, (iv) any failure of Consultant to perform the Services in accordance with all applicable laws, rules and regulations, or (v) any violation or claimed violation of a third party’s
rights resulting in whole or in part from the Company’s use of the Inventions or other deliverables of Consultant under this Agreement. 
  

	 	11.	Nonsolicitation 

 To the fullest extent permitted under applicable law, from the date of
this Agreement until twelve (12) months after the termination of this Agreement for any reason (the “Restricted Period”), Consultant will not, without the Company’s prior written consent, directly or indirectly,
solicit any of the Company’s employees to leave their employment, or attempt to solicit employees of the Company, either for Consultant or for any other person or entity. Consultant agrees that nothing in this Article 11 shall affect
Consultant’s continuing obligations under this Agreement during and after this twelve (12) month period, including, without limitation, Consultant’s obligations under Article 3. 

 

	 	12.	Public Statements 

 Company agrees that it will not make any public statement which
specifically refers to Consultant unless the proposed statement has been provided to Consultant for his review and approval at least forty-eight (48) hours before publication and Company receives Consultant’s approval. 

 

	 	13.	Arbitration and Equitable Relief 

 A. Arbitration. IN CONSIDERATION OF
CONSULTANT’S CONSULTING RELATIONSHIP WITH COMPANY, ITS PROMISE TO ARBITRATE ALL DISPUTES RELATED TO CONSULTANT’S CONSULTING RELATIONSHIP WITH THE COMPANY AND CONSULTANT’S RECEIPT OF THE COMPENSATION AND OTHER BENEFITS PAID TO
CONSULTANT BY COMPANY, AT PRESENT AND IN THE FUTURE, CONSULTANT AGREES THAT ANY AND ALL CONTROVERSIES, CLAIMS, OR DISPUTES WITH ANYONE (INCLUDING COMPANY AND ANY EMPLOYEE, OFFICER, DIRECTOR, SHAREHOLDER OR BENEFIT PLAN OF THE COMPANY IN THEIR
CAPACITY AS SUCH OR OTHERWISE), WHETHER BROUGHT ON AN INDIVIDUAL, GROUP, OR CLASS BASIS, ARISING OUT OF, RELATING TO, OR RESULTING FROM CONSULTANT’S CONSULTING RELATIONSHIP WITH THE COMPANY OR THE TERMINATION OF CONSULTANT’S CONSULTING
RELATIONSHIP WITH THE COMPANY, INCLUDING ANY BREACH OF THIS AGREEMENT, SHALL BE SUBJECT TO BINDING ARBITRATION UNDER THE ARBITRATION RULES SET FORTH IN THE GENERAL LAWS OF MASSACHUSETTS, CHAPTER 251 (THE “RULES”) AND PURSUANT
TO MASSACHUSETTS LAW. THE FEDERAL ARBITRATION ACT SHALL CONTINUE TO APPLY WITH FULL FORCE AND EFFECT NOTWITHSTANDING THE APPLICATION OF PROCEDURAL RULES SET FORTH IN THE ACT. DISPUTES WHICH CONSULTANT AGREES TO ARBITRATE, AND THEREBY AGREES TO
WAIVE ANY RIGHT TO A TRIAL BY JURY, INCLUDE ANY STATUTORY CLAIMS UNDER LOCAL, STATE, OR FEDERAL LAW, INCLUDING, BUT NOT LIMITED TO, CLAIMS UNDER TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, THE CIVIL RIGHTS ACT OF 1991, THE AMERICANS WITH DISABILITIES
ACT OF 1990, THE AGE DISCRIMINATION IN EMPLOYMENT ACT OF 1967, THE OLDER WORKERS BENEFIT PROTECTION ACT, THE SARBANES-OXLEY ACT, THE WORKER ADJUSTMENT AND RETRAINING NOTIFICATION ACT, THE FAIR CREDIT REPORTING

  
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ACT, THE EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974, THE FAMILY AND MEDICAL LEAVE ACT, THE MASSACHUSETTS FAIR EMPLOYMENT PRACTICES ACT, THE MASSACHUSETTS CIVIL RIGHTS ACT, THE
MASSACHUSETTS EQUAL PAY ACT, THE MASSACHUSETTS EQUAL RIGHTS ACT, THE GENERAL LAWS OF MASSACHUSETTS, CLAIMS OF HARASSMENT, DISCRIMINATION OR WRONGFUL TERMINATION AND ANY STATUTORY CLAIMS. CONSULTANT FURTHER UNDERSTANDS THAT THIS AGREEMENT TO
ARBITRATE ALSO APPLIES TO ANY DISPUTES THAT THE COMPANY MAY HAVE WITH CONSULTANT. 
 B. Procedure. CONSULTANT AGREES THAT ANY
ARBITRATION WILL BE ADMINISTERED BY JUDICIAL ARBITRATION & MEDIATION SERVICES, INC. (“JAMS”) PURSUANT TO ITS COMMERCIAL ARBITRATION RULES & PROCEDURES (THE “JAMS RULES”). CONSULTANT
AGREES THAT THE ARBITRATOR SHALL HAVE THE POWER TO DECIDE ANY MOTIONS BROUGHT BY ANY PARTY TO THE ARBITRATION, INCLUDING MOTIONS FOR SUMMARY JUDGMENT AND/OR ADJUDICATION AND MOTIONS TO DISMISS AND DEMURRERS, PRIOR TO ANY ARBITRATION HEARING.
CONSULTANT AGREES THAT THE ARBITRATOR SHALL ISSUE A WRITTEN DECISION ON THE MERITS. CONSULTANT ALSO AGREES THAT THE ARBITRATOR SHALL HAVE THE POWER TO AWARD ANY REMEDIES AVAILABLE UNDER APPLICABLE LAW, AND THAT THE ARBITRATOR SHALL AWARD
ATTORNEYS’ FEES AND COSTS TO THE PREVAILING PARTY, EXCEPT AS PROHIBITED BY LAW. CONSULTANT AGREES THAT THE DECREE OR AWARD RENDERED BY THE ARBITRATOR MAY BE ENTERED AS A FINAL AND BINDING JUDGMENT IN ANY COURT HAVING JURISDICTION THEREOF.
CONSULTANT AGREES THAT THE ARBITRATOR SHALL ADMINISTER AND CONDUCT ANY ARBITRATION IN ACCORDANCE WITH MASSACHUSETTS LAW AND THAT THE ARBITRATOR SHALL APPLY SUBSTANTIVE AND PROCEDURAL MASSACHUSETTS LAW TO ANY DISPUTE OR CLAIM, WITHOUT REFERENCE TO
RULES OF CONFLICT OF LAW. TO THE EXTENT THAT THE JAMS RULES CONFLICT WITH MASSACHUSETTS LAW, MASSACHUSETTS LAW SHALL TAKE PRECEDENCE. CONSULTANT AND COMPANY BOTH AGREE THAT ANY ARBITRATION UNDER THIS AGREEMENT SHALL BE CONDUCTED IN MASSACHUSETTS.

 C. Remedy. EXCEPT AS PROVIDED BY THE ACT AND THIS AGREEMENT, ARBITRATION SHALL BE THE SOLE, EXCLUSIVE, AND FINAL REMEDY FOR
ANY DISPUTE BETWEEN CONSULTANT AND THE COMPANY. ACCORDINGLY, EXCEPT AS PROVIDED FOR BY THE ACT AND THIS AGREEMENT, NEITHER CONSULTANT NOR THE COMPANY WILL BE PERMITTED TO PURSUE COURT ACTION REGARDING CLAIMS THAT ARE SUBJECT TO ARBITRATION. 

D. Availability of Injunctive Relief. BOTH PARTIES AGREE THAT ANY PARTY MAY ALSO PETITION THE COURT FOR INJUNCTIVE RELIEF WHERE
EITHER PARTY ALLEGES OR CLAIMS A VIOLATION OF ANY AGREEMENT REGARDING INTELLECTUAL PROPERTY, CONFIDENTIAL INFORMATION OR NONINTERFERENCE. IN THE EVENT EITHER PARTY SEEKS INJUNCTIVE RELIEF, THE PREVAILING PARTY SHALL BE ENTITLED TO RECOVER REASONABLE
COSTS AND ATTORNEYS’ FEES. THE “PREVAILING PARTY” MEANS THE PARTY DETERMINED TO HAVE MOST NEARLY PREVAILED, EVEN IF SUCH PARTY DID NOT PREVAIL IN ALL MATTERS, AND NOT NECESSARILY THE ONE IN WHOSE FAVOR AN AWARD, JUDGMENT OR FINAL
ORDER IS RENDERED OR ISSUED. 
 E. Administrative Relief. CONSULTANT UNDERSTANDS THAT THIS AGREEMENT DOES NOT PROHIBIT
CONSULTANT FROM PURSUING AN ADMINISTRATIVE CLAIM WITH A LOCAL, STATE OR FEDERAL ADMINISTRATIVE BODY OR GOVERNMENT 

  
 -7- 

 
AGENCY SUCH AS THE DEPARTMENT OF FAIR EMPLOYMENT AND HOUSING, THE EQUAL EMPLOYMENT OPPORTUNITY COMMISSION, THE NATIONAL LABOR RELATIONS BOARD, OR THE WORKERS’ COMPENSATION BOARD. THIS
AGREEMENT DOES, HOWEVER, PRECLUDE CONSULTANT FROM PURSUING COURT ACTION REGARDING ANY SUCH CLAIM, EXCEPT AS PERMITTED BY LAW. 
 F.
Voluntary Nature of Agreement. CONSULTANT ACKNOWLEDGES AND AGREES THAT IT IS EXECUTING THIS AGREEMENT VOLUNTARILY AND WITHOUT ANY DURESS OR UNDUE INFLUENCE BY THE COMPANY OR ANYONE ELSE. CONSULTANT FURTHER ACKNOWLEDGES AND AGREES THAT
IT HAS CAREFULLY READ THIS AGREEMENT AND THAT CONSULTANT HAS ASKED ANY QUESTIONS NEEDED FOR CONSULTANT TO UNDERSTAND THE TERMS, CONSEQUENCES AND BINDING EFFECT OF THIS AGREEMENT AND FULLY UNDERSTAND IT, INCLUDING THAT CONSULTANT IS WAIVING ITS
RIGHT TO A JURY TRIAL. FINALLY, CONSULTANT AGREES THAT IT HAS BEEN PROVIDED AN OPPORTUNITY TO SEEK THE ADVICE OF AN ATTORNEY OF CONSULTANT’S CHOICE BEFORE SIGNING THIS AGREEMENT. 

 

	 	14.	Miscellaneous 

 A. Governing Law; Consent to Personal Jurisdiction. This
Agreement shall be governed by the laws of the State of Massachusetts, without regard to the conflicts of law provisions of any jurisdiction. To the extent that any lawsuit is permitted under this Agreement, the Parties hereby expressly consent to
the personal and exclusive jurisdiction and venue of the state and federal courts located in Massachusetts. 
 B.
Assignability. Consultant may assign any or all of his obligations and any or all of his rights under this Agreement to any entity which Consultant may at the relevant time substantially own or control including, without limitation,
Verdyne Corporation, a Verdine family trust, or an LLC so long as Greg Verdine directly and personally renders all of the Services and Greg Verdine remains liable for all obligations of Consultant. This Agreement will be binding upon
Consultant’s heirs, executors, assigns, administrators, and other legal representatives, and will be for the benefit of the Company, its successors, and its assigns. There are no intended third-party beneficiaries to this Agreement, except as
expressly stated. Except as may otherwise be provided in this Agreement, Consultant may not sell, assign or delegate any rights or obligations under this Agreement. Notwithstanding anything to the contrary herein, Company may assign this Agreement
and its rights and obligations under this Agreement to any successor to all or substantially all of Company’s relevant assets, whether by merger, consolidation, reorganization, reincorporation, sale of assets or stock, or otherwise. 

C. Entire Agreement. This Agreement constitutes the entire agreement and understanding between the Parties with respect to the
subject matter herein and supersedes all prior written and oral agreements, discussions, or representations between the Parties. Consultant represents and warrants that he is not relying on any statement or representation not contained in this
Agreement. 
 D. Headings. Headings are used in this Agreement for reference only and shall not be considered when
interpreting this Agreement. 
 E. Severability. If a court or other body of competent jurisdiction finds, or the Parties
mutually believe, any provision of this Agreement, or portion thereof, to be invalid or unenforceable, such provision will be enforced to the maximum extent permissible so as to effect the intent of the Parties, and the remainder of this Agreement
will continue in full force and effect. 

  
 -8- 

 F. Modification, Waiver. No modification of or amendment to this Agreement, nor any
waiver of any rights under this Agreement, will be effective unless in a writing signed by the Parties. Waiver by either Party of a breach of any provision of this Agreement will not operate as a waiver of any other or subsequent breach. 

G. Notices. Any notice or other communication required or permitted by this Agreement to be given to a Party shall be in writing
and shall be deemed given (i) if delivered personally or by commercial messenger or courier service, (ii) when sent by confirmed facsimile, or (iii) if mailed by U.S. registered or certified mail (return receipt requested), to the Party at the
Party’s address written below or at such other address as the Party may have previously specified by like notice. If by mail, delivery shall be deemed effective three (3) business days after mailing in accordance with this Section 14.G.

 (1) If to the Company, to: 

419 Western Avenue ,Boston, Mass. 02135 

Attention: Ken Takanashi 
 (2)
If to Consultant, to the address for notice on the signature page to this Agreement or, if no such address is provided by Consultant to the Company. 

H. Attorneys’ Fees. In any court action at law or equity that is brought by one of the Parties to this Agreement to enforce
or interpret the provisions of this Agreement, the prevailing Party will be entitled to reasonable attorneys’ fees, in addition to any other relief to which that Party may be entitled. The “prevailing Party” means the Party determined
to have most nearly prevailed, even if such Party did not prevail in all matters, and not necessarily the one in whose favor an award, judgment or final order is rendered or issued. 

I. Signatures. This Agreement may be signed in two (2) counterparts, each of which shall be deemed an original, and both of
which together shall constitute one (1) document. 
 (signature page follows) 

  
 -9- 

 IN WITNESS WHEREOF, the Parties hereto have executed this Consulting Agreement as of the date
first written above. 
  

							
	CONSULTANT	 	ONTORII, INC.
				
	By:	 	 /s/ Gregory L. Verdine
	 	By:	 	 /s/ Ken Takanashi

				
	Name:	 	 Gregory L. Verdine
	 	Name:	 	 Ken Takanashi

				
	Title:	 	  
	 	Title:	 	 Director

 Address for Notice: 
 [Address]

 EXHIBIT A 

SERVICES AND COMPENSATION 
  

	 	1.	Contact. Consultant’s principal Company contact: 

  

			
	Name:	  	 Ken Takanashi

		
	Title:	  	 Director / Corporate Secretary

		
	Email:	  	  

		
	Phone:	  	  

  

	 	2.	Services. The Services will be the following: 

 Consultant shall provide research
and development advice relating to the use of oligonucleotides and modified versions thereof as drugs, and Consultant shall serve as Co-Chair of the Company’s Scientific Advisory Board. Consultant shall provide approximately one (1) day,
which is defined to be a maximum of eight (8) hours, per week of Services to the Company during the term of this Agreement. 
  

	 	3	Compensation. 

 A. The Company will pay Consultant $12,500 per month, or any part
of a calendar month, for the Services provided hereunder until this Agreement terminates. This payment will be made automatically, in arrears, on a monthly basis, with no invoicing. The accumulated fees due for the period between April 1, 2012
and the signing date of this agreement will be paid immediately upon signing, in one lump sum, in recognition of the Consultant’s having provided services during that period. 

B. The Company will reimburse Consultant, in accordance with Company policy, for all reasonable expenses incurred by Consultant in performing
the Services pursuant to this Agreement, if Consultant receives written consent from an authorized agent of the Company for incurring such expenses and submits receipts for such expenses to the Company in accordance with Company policy. 

This Exhibit A is accepted and agreed upon as of 1st April 2012. 

 

							
	CONSULTANT	 	ONTORII, INC.
				
	By:	 	 /s/ Gregory L. Verdine
	 	By:	 	 /s/ Ken Takanashi

				
	Name:	 	 Gregory L. Verdine
	 	Name:	 	 Ken Takanashi

				
	Title:	 	  
	 	Title:	 	 Director

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