Document:

Lease Agreement

 Exhibit 10.21 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 230.406. 

English Translation for Convenience 

LEASE AGREEMENT 

for rented commercial premises 

Between 
 Alters- und
Hinterbliebenen-Versorgungsstelle der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstraße 58 
 45138 Essen

 - Lessor - 
 UST (turnover tax) ID:
DE11 98 24807 
 and 
 Business name

 Nitec Pharma GmbH 
 - Lessee -

 UST (turnover tax) ID: 37009/52183 

the following agreement will be concluded: 

 LEASE AGREEMENT FOR OFFICE AND 

ADMINISTRATION SPACE 

CONTENT and ANNEXES 
  

					
	 Page
	  	 Content

		
	1	  	Table of contents
			
	3	  	§1	  	 Leased Object

	3	  	§2	  	 Use of Leased Object

			
	4	  	§3	  	 Furnishing of the Rental Space

	4	  	§4	  	 Length of Lease, Termination

			
	5	  	§5	  	 Rent

			
	6	  	§6	  	 Turnover Tax

	6	  	§7	  	 Changes to Rent

			
	7	  	§8	  	 Payment of Rent

	7	  	§9	  	 Transfer and Condition of Leased Object

	7	  	§10	  	 Use by Third Parties

			
	8	  	§11	  	 Maintenance and Repair

	8	  	§12	  	 Insurance

			
	 8
	  	§13	  	 Signage/Advertising Property

	9	  	§14	  	 Surveillance and Security Systems

			
	 9
	  	§15	  	 Defects to Leased Object/Counterclaims

	 9
	  	§16	  	 Modifications to Leased Object Made by the Lessee

	 9
	  	§17	  	 Modifications to Leased Object Made by the Lessor

	1	  		  	
	 10
	  	§18	  	 Accessing and Entering the Leased Object

	 10
	  	§19	  	 Lessor's Lien/Provision of Security

			
	 11
	  	§20	  	 Termination of Lease

			
	 12
	  	§21	  	 Miscellaneous

			
	Annex I	  		  	 List of Operating Expenses and Service Charges

			
	Annex II	  		  	 Ground Plans of the Rental Space

 § 1 - Leased Object 

 

	1.1	The Lessor is the owner of the property, Joseph-Meyer-Straße 13-15, 68167 Mannheim, Germany. 

 

	1.2	 The Lessor shall lease office space totalling 171.18 sqm. on the 2nd floor of the building described above to the Lessee. This includes main floor
space and ancillary space and the associated public thoroughfares and floor space occupied by technical and building service installations. 

The enclosed site plan is part of the Lease Agreement (Annex II). 

 

	1.3	If subsequent measurements of the rental space deviate from the floor space provided here, neither Party has the right to rescind this Agreement, to terminate this
Agreement or to demand a change in rent. The floor space indicated is to be taken as the basis whenever the size of the rental space is referred to in the provisions of this Agreement. 

 

	1.4	The space is being rented for use as an office. 

Any changes in this type of use are only permissible upon obtaining written permission from the Lessor. In all cases, permission given by
the Lessor shall be granted subject to first obtaining a required official permit to change the type of use, even if the Lessor does not remind the Lessee of the need to do this at that time. The Lessee must acquire this permit at his own expense
and present it to the Lessor. 
 § 2 - Use of Leased Object 

 

	2.1	The leased object shall be leased by the Lessee for the type of use specified in item 1.4. 

 

	2.2	The Lessor does not guarantee that the business the Lessee plans to conduct in the leased object is permissible according to public law. The Lessee must fulfill
numerous criteria at his own expense in relation to the conduct of his business for the duration of lease. The Lessee must comply with requirements imposed by the trade supervisory office or other authorities and do so regarding space-related
requirements as well. 

 The validity of this Lease Agreement is not contingent on an official permit permitting
the lessee’s business activities. 
  

	2.3	The Lessee undertakes to actively conduct his business and keep it open and operating in accordance with the type of business being conducted (contractual operation to
use, open or operate) for the duration of this Agreement. 

  

	2.4	The Lessor shall not grant the Lessee any protection against competition. 

  

 Page 3 of the Lease Agreement of December 21, 2004 

	2.5	The Lessee shall ask the Lessor for information about the load limit of the ceilings and obtain the Lessor's written approval before setting up machines, heavy objects
or other equipment in the rental space. The Lessee shall be liable for any damages that occur because of failure to comply with these provisions. If the Lessee's equipment as described above causes damage to the building (shaking, cracks, etc.) or
disturbances or has detrimental effects (e.g., noise, dust, disturbing smells, etc.) for other lessees of the building, the Lessor may revoke his approval and demand that the Lessee refrain from these activities. 

 

	2.6	Lease of the object shall include the right of free access to the leased object. 

§ 3 - Furnishing and Transfer of the Rental Space by the Lessor 

 

	3.1	The Lessee is aware of the current condition and layout of the leased object. 

 

	3.2	The leased object will be handed over to the Lessee by January 2005 at the latest. A record shall be made of the transfer. 

§ 4 - Length of Lease and Termination 
  

	4.1	Tenancy shall begin on January 1, 2005, and terminate after 1.5 years on June 30, 2006. section 568 of the German Civil Code (BGB) does not apply to the
Contracting Parties once tenancy has been terminated. 

  

	4.2	Ordinary notice of termination shall be excluded for the duration of tenancy. The right of both Parties to immediate termination without notice for good cause shall
remain unaffected. The right of the Lessor to effect immediate termination without notice applies particularly when: 

  

	 	a)	the Lessee is behind by more than one month's rent or has not provided the security agreed to in the amount, period of time and means stipulated in the Agreement;

  

	 	b)	the Lessee makes structural changes to the leased object or to parts thereof without first obtaining the Lessor's permission or uses it for purposes other than those
stipulated in the Agreement, in particular subletting it to third parties; 

  

	 	c)	the Lessee ceases payment, it comes to legal or out-of-court settlement or bankruptcy proceedings regarding his assets or he is required to make an oath regarding his
assets; 

  

 Page 4 of the Lease Agreement of December 21, 2004 

	 	d)	if the Lessee fails to comply with the terms of contract despite two written warnings regarding the same. 

 

	4.3	The Lessee has the option to extend the Lease Agreement by one, two or three years once the term of the Lease Agreement as specified under item 4.1 has expired. If the
Lessee chooses to exercise this option, he shall notify the Lessor of this decision in writing 6 months prior to expiration of tenancy. The Agreement shall be terminated 6 months prior to the relevant date of expiration. 

 

	4.5	If the Lessee is a natural person, the right of early termination pursuant to section 569 of the German Civil Code (BGB) shall hereby be excluded.

 § 5 - Rent 
  

	5.1	Rent for the basic leasing period from January 1, 2005, until June 30, 2006, shall be calculated as follows: 

 

									
	 Office space
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
	 3 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Subtotal, net
	  		  		  		  	[...***...]
	 16 % value-added tax
	  		  		  		  	[...***...]
		  		  		  		  	 
					
	 Gross total
	  		  		  		  	[...***...]
		  		  		  		  	 

 If the Lessee decides to exercise the option stipulated
in item 4 for one year, the rent in the amount of [...***...] shall remain the same. For a two-year duration, rent shall be reduced to [...***...] per sqm and to [...***...] per sqm for a duration of three years. 

 

	5.2	In addition to basic rent, the Lessee shall pay all operating expenses for the leased object that are attributed directly to him (e. g., electricity, gas, water,
telephone and other communications expenses) as well as all of the building operating expenses and service charges. Operating expenses and service charges comprise all costs listed in Annex I of this Agreement as well as any costs that may
arise in the future, having been newly introduced for the leased object by law, regulation, by-law or for any other reason. The list of operating expenses and service charges pursuant to Annex I is therefore an example and not a final listing of all
possible costs. 

  

	5.3	The Lessor shall apportion these operating expenses and service charges to the Lessee and settle these with him. If there are several lessees in the building, the
Lessor shall determine how these costs should be distributed (distribution legend) to the extent he is required to do so by legal provisions and shall do so in accordance with these provisions. The distribution legend shall be based on the share of
leased space from the total area. 

  

 Page 5 of the Lease Agreement of December 21, 2004 

 

			
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	5.4	The Lessor shall invoice these expenses annually by December 15th of the following year at the latest. Should tenancy end during a billing period, the expenses
shall be invoiced within the scope of the following annual accounting activities. 

  

	5.5	If operating costs increase or can be reasonably expected to increase (e. g., due to notification of an increase in local charges), the Lessor has the right to demand a
corresponding increase in the advance payments. 

 § 6 - Turnover Tax 

 

	6.1	In addition to the stipulated basic rent including operating expenses and service charges, the Lessor shall pay turnover tax as it falls due as prescribed under law.
The Lessee guarantees that he intends to use the rental space exclusively for generating turnover which does not exclude the Lessor from deducting input tax. If the Lessee does not use the rental space exclusively to generate profit that does not
exclude input tax deduction as promised (use having negative tax effects), basic rent including service charges shall increase for the period of use having negative tax effects by whichever amount is equal to the basic rent plus operating expenses
and service charges for the turnover tax paid. 

  

	6:2	Upon the Lessor's request, the Lessee shall provide proof that he is using the leased object solely to generate profit that does not exclude input tax deduction. The
Lessee shall immediately inform the Lessor before he starts using the leased object for use having negative tax effects and compensate the Lessor for any damage that may arise due to the Lessee violating his obligation to give notice; this
particularly includes damage caused to the Lessor by paying turnover tax to the internal revenue service after the leased object has begun to be used for purposes having negative tax effects, even though lease of the object is at that time no longer
subject to turnover tax. Claims for damages of this nature shall not become statute-barred until 6 months after a tax authority or tax court has determined that the Lessor does not or no longer has the right to input tax deduction.

 § 7 - Changes to Rent 
  

	7.1.	If the price index determined by the German Federal Statistics Office for the standard of living for all private households (consumer price index for Germany) (base
year 2000 = 100 points) changes as compared to its state as of June 30, 2009, or as compared to the last adjustment of rent by more than [...***...], the basic rent stipulated in item 5 shall be proportionally modified accordingly.
Changes shall become effective on the first day of the month in which the change has been made. 

  

 Page 6 of the Lease Agreement of December 21, 2004 

 

			
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	7.2.	 If this adjustment clause cannot be considered approved pursuant to item 4 of the price clause decree, the Parties undertake to agree on an adjustment
clause that comes as close as possible to the commercial concept and purpose of the original clause which can be approved according to the provisions valid at that time. 

§ 8 - Payment of Rent 

Payment of rent shall begin on January 1, 2005. 

Rent is due by the 3rd business day of each month at the latest and shall be paid to the following account: [...***...]. 

§ 9 - Transfer of Leased Object / Condition of Leased Object 
  

	9.1	Transfer of the leased object is scheduled to take place at the start of the rental period pursuant to item 4.1. The Lessor shall notify the Lessee of the official
transfer date in writing as soon as possible. 

 Any work that still needs to be done, e. g., complete provision of
outdoor facilities and/or repair of defects, shall not prevent transfer of the leased object. 
  

	9.2	The Parties shall make a record of the transfer at the time of transfer documenting the condition of the leased object as well as any defects present at that time.

 The Lessor shall repair any defects identified in the record of transfer within a reasonable amount of time.

 § 10 - Use by Third Parties 
  

	10.1	Any partial or complete use by third parties, particularly subletting the leased object, requires the Lessor’s prior consent. The Lessee shall not have the right
to terminate the lease should the Lessor not give his consent. The Lessee shall be responsible for and bear the costs of meeting any conditions stipulated by the authorities within the scope of such transfer of use so that the leased object can be
used for other purposes that have been approved by the Lessor. 

  

	10.1	The Lessor may revoke his approval of a subletting arrangement for good cause. However, this may not be done at an inopportune time. 

 

 Page 7 of the Lease Agreement of December 21, 2004 

 

			
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 § 11 - Maintenance/Repairs/Decorative Repairs/Liability for Damages 

 

	11.1	The Lessee shall be responsible for decorative repairs as well as other maintenance and repair work inside the rental space as well as any damage caused by lessee use
(wear and tear, deterioration, damage caused by the Lessee or his helpers). 

 §12 - Insurance 

 

	12.1	Standard building insurance (fire, storm, damage from mains water, extended coverage) and premises liability insurance shall be concluded by the Lessor and billed
together with the operating expenses and service charges. The installation of any fixtures in or additions or renovations to the leased object conducted by the Lessee shall not be covered by the building insurance. The Lessee shall be obliged to
obtain insurance for these fixtures, additions or renovations at his own cost. 

  

	12.2	The Lessee shall be obliged to obtain sufficient business liability insurance as well as insurance covering breaking and entering as well as theft and sufficient
insurance against any damage to equipment and objects brought into the leased object at his own expense and to maintain these insurance policies for the length of the lease. 

 

	12.3	The Lessor has the right to view the insurance contracts as proof that the Lessee has obtained the insurance policies listed under item 12.2 and that these are being
maintained. This also applies to payment of the first premium for each insurance policy. 

 § 13 - Signage/Advertising

  

	13.1	The Lessee shall be permitted to place nameplates and company signs in the entrance area and at the doors to the rented rooms in those places designated by the Lessor
for this purpose. Other building sections or areas of the property are not part of this lease; advertising installations, vending machines, display windows, stands, signs, awnings, antennae, etc., may therefore not be installed or set up.

  

	13.2	Any additional advertising installations or materials pursuant to item 13.1 that the Lessee wishes to install or set up shall require the Lessee to obtain the Lessor's
written, prior consent, which may involve conditions and expenses to be paid by the Lessee. 

  

	13.3	The Lessor shall reserve the right to make sure that signage or any advertising or other installations are designed in accordance with a joint advertising concept for
the property. The Lessee must adjust his signage and advertising and other installations so that they correspond to this uniform concept. The Lessee shall bear the costs for signage. 

 

 Page 8 of the Lease Agreement of December 21, 2004 

 § 14 - Property Surveillance and Security Systems 

 

	14.1	Should the Parties deem surveillance measures necessary for the property, the Lessee shall tolerate these to the extent he is notified of said measures in due time. The
Lessee shall be obliged to bear any costs incurring with respect to this matter. If there are several lessees, these costs shall be divided among them in accordance with the scale used for other operating expenses and service charges.

  

	14.2	This shall also apply should the Lessor install security systems. Installation of security systems inside the premises by the Lessee shall require the prior consent
from the Lessor. 

 § 15 - Defects to Leased Object/Counterclaims 

The legal provisions shall apply. 

§ 16 - Modifications to Leased Object made by the Lessee 
  

	16.1	Modifications made to and in the leased object, particularly rebuilding, fixtures, installations and similar modifications, may only be made after obtaining written
consent from the Lessor. 

  

	16.2	Gas, electronic and other devices may only be hooked up to the available supply network to an extent that does not exceed the usage limit designated for the leased
object. 

 § 17 - Modifications to Leased Object made by the Lessor 

 

	17.1	The Lessor shall have the right to make repairs and structural changes that become necessary or are advisable for maintenance, to avoid possible hazards, repair damages
or improve the leased object and rental thereof even without the Lessee's consent. The Lessee shall make sure that the affected rooms and space are accessible and may not prevent or delay completion of the work; should he do this, the Lessee shall
pay for any damage that arises. 

  

	17.2	The Lessor shall make allowances for the Lessee's business affairs. In particular, the Lessor shall inform the Lessee of such work in due time. This obligation to
inform the Lessee shall not apply in the case of imminent danger. 

  

 Page 9 of the Lease Agreement of December 21, 2004 

 § 18 - Accessing and Entering the Leased Object 

The Lessee shall guarantee that the Lessor or his agents, experts or interested parties are able to enter and view the leased object at
any time during standard business hours for the purposes of re-letting, sale, assessing the condition of the leased object or doing work on the leased object, if the Lessee has been notified in advance. 

The Lessee shall guarantee that the leased object can be accessed and entered at any time of day or night in the case of imminent danger.

 § 19 - Lessor’s Lien / Provision of Security 

 

	19.1	The Lessor has a lessor’s lien on items brought into the leased object by the Lessee (office furniture, machines and other objects for business use and furnishing)
for all present and future claims under this Agreement. 

  

	19.2	If third parties pledges items brought into the leased object by the Lessee, the Lessee shall be obliged to immediately notify the Lessor of the details and scope of
the pledge by providing him with the relevant documents. 

  

	19.3	At least 14 days prior to the commencement of the lease pursuant to section 4.1 the Lessee shall provide security (guarantee) in the amount of [...***...]
rent plus the agreed or estimated operating expenses and service charges as well as the applicable value-added tax in the amount of 

[...***...] 

[...***...] 

as security for all the Lessor's claims under this Agreement and its termination. 

(Translator’s note: The amount indicated in numbers and that indicated in words do not correspond in the original document and
have therefore been translated as such.) 
 Security shall be provided in the form of an unconditional, irrevocable and
unlimited guarantee for which the Lessee is liable as the sole principal from a major bank headquartered in the Federal Republic of Germany for which the guaranteeing bank shall waive the right to appeal, to offset and to deposit and the rights and
objections from sections 768 and 776 of the German Civil Code (BGB) and which is obligated to pay on the first request to do so by the Lessor. 

The guarantee may not contain any further conditions or limitations beyond the provision that the guarantee obligation shall be returned,
if the Lessor returns the bank guarantee to the guarantor or if the lease is terminated and all of the Lessee's obligations arising from said lease have been fulfilled, if applicable reduced by the amount claimed by the Lessor. 

 

 Page 10 of the Lease Agreement of December 21, 2004 

 

			
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	19.4	In the event changes are made to basic rent during tenancy and/or to the operating expenses and service charges by at least [...***...] of the previous monthly
total, the Lessee shall be obliged to adjust his provision of security accordingly, if requested to do so by the Lessor within 14 days of receiving said request. 

§ 20 - Termination of Lease 
  

	20.1	Once lease has been terminated, the Lessee shall return the leased object cleaned and in suitable condition together with all keys to the Lessor. The Lessee shall also
conduct any necessary decorative repairs, maintenance and other repairs that he is obligated to conduct pursuant to section 11 until the end of the lease; should the Lessee fail to do so, the Lessor may conduct such repairs and measures himself
instead of the Lessee at the Lessee's cost without reminding the Lessee that he is obligated to make such repairs. 

  

	20.2	Objects that the Lessee has placed in the leased object and any changes made by him to the leased object during the lease, particularly fixtures and renovation,
including signage, advertising installations and other installations in accordance with item 13 of this Agreement must be professionally removed and the original state of the lease object needs to be established by the Lessee.

 The Lessee shall not remove the cabling, the built-in server room and the air conditioning unit located in the
server room present in the premises at the commencement of the lease, after moving out of the leased object. 
 The Lessor may
avert the exercise of this right to remove an article by paying suitable compensation based on the current value of the object. 
  

 Page 11 of the Lease Agreement of December 21, 2004 

 

			
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 § 21 Miscellaneous 

 

	21.1	Place of fulfillment and court of jurisdiction for all obligations in connection with this Agreement shall be Mannheim, Germany. 

 

	21.2	Should one or more provisions of this Agreement be invalid, this shall not affect the validity of the other provisions. The Parties shall replace the invalid provision
by an effective provision with retroactively effect, on which they would reasonably have agreed had they previewed the invalidity or absence of the respective provision. 

 

	21.3	Supplementary agreements, changes, additions and cancellation of the Agreement are only effective if conducted in writing. This also applies to any kind of permission
or consent. The written form requirement may only be waived expressly and in written form. In particular, any declarations arising within the scope of this Agreement such as cancellations, consent, permits and similar declarations shall be made in
writing to be effective. 

  

	21.4	The built-in server room in the offices, including technical installations (e.g., additional cabling, air conditioning unit) as well as the additional door closing
system including installations shall remain in the premises after the Lessee has moved out. 

  

	21.5	Reference shall be made to the Annexes I - II associated with this Agreement. 

 

							
	Essen, January 6, 2005	 		 	Munich, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]     [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 12 of the Lease Agreement of December 21, 2004 

 Annex I to the Lease Agreement AHV / Nitec Pharma 

LIST OF OPERATING EXPENSES AND SERVICE CHARGES 

The following running costs that are incurred by the owner due to his ownership of the property or due to the intended use of the building or the economic
unit, the adjoining buildings, facilities, installations and property, unless they are usually borne directly by the Lessee in addition to the rent, constitute the operating expenses and service charges: 

 

	1.	Current public rates and charges for the property 

These namely comprises the land tax. 
  

	2.	Costs for water supply 

These comprise the costs for water consumption, basic charges and charges for renting meters, costs for using intermediate meters as well
as operating costs. 
  

	3.	Drainage costs 

 These
comprise the charges for use of a public drainage system, including discharge of rainwater as well as operating costs. 
  

	4.	Heating system costs 

These comprise the operating and cleaning costs 
  

	 	a)	for the heating system as well as the costs for using measuring equipment to measure consumption. Heating systems may, for example, be central heating systems or
heating systems connected to the hot water supply system, central fuel supply systems or floor heating systems 

  

	 	b)	costs for district heating and operating costs 

  

	 	c)	costs for reading and analysis of the equipment to measure consumption. 

  

	5.	Costs of hot water supply 

These include the operating and cleaning costs for 
  

	 	a)	hot water supply facilities, such as central hot water supply facilities or hot water supply facilities connected to the heating system; 

 

	 	b)	costs for supplying with district hot water and operating costs for the associated facilities in the building; 

 

 Page 1 of the Annex I to the Lease Agreement of December 21, 2004 

	 	c)	hot water units and equipment to measure consumption; 

  

	 	d)	costs for reading and analysis of the equipment to measure consumption. 

  

	6.	Costs for air conditioning and ventilation systems 

These comprise the operating costs. 
  

	7.	Costs for the passenger elevator or freight elevator 

These comprise the costs for the operational electricity, supervision costs, service costs, costs of monitoring the installation and
maintenance costs, costs for regularly checking it for operational readiness and operational safety, including adjustment by an expert and cleaning costs. 
  

	8.	Costs for street cleaning and garbage disposal 

These comprise the fees to be paid for public street cleaning and garbage disposal as well as the costs for corresponding non-public
measures. 
  

	9.	Costs for cleaning and pest control 

Cleaning costs include, among others, costs for cleaning the property, in particular access and entrance areas, corridors, staircases,
basements, attic spaces, laundry rooms, technology rooms, lift cages and facades as well as costs for glass cleaning. 
  

	10	Costs for outside facilities 

These comprise costs for horticultural upkeep and ground maintenance, including replanting of plants and trees and the upkeep of
playgrounds, including replacing sand. These also include upkeep, cleaning, snow removal and strewing sand or other suitable material in areas, access areas and driveways that are not used for public traffic. 

 

	11.	Lighting costs 

 These
comprise the electricity costs for outdoor lighting and the indoor lighting of general building sections, such as access and entrance areas, corridors, staircases, basements, attic areas, laundry rooms and technology rooms. 

 

 Page 2 of the Annex I to the Lease Agreement of December 21, 2004 

	12.	Costs of cleaning pipes and chimneys 

These comprise fees for cleaning pipes and chimneys pursuant to the applicable list of fees. 

 

	13.	Insurance costs 

 These
comprise the costs for all insurance policies that have been taken out for the object, such as building insurance with all-risk coverage, glass insurance, liability insurance for the building, the oil tank and the elevator as well as insurance
against loss of rent. 
  

	14.	Costs for the janitor, porter or doorman and all other staff required for building operation 

These include, inter alia, ancillary labor costs and special remuneration. 

 

	15.	Costs for signage and advertising installations 

These comprise costs for installing and operating signs and advertising installations. Signage comprises business name, name, location and
information signs. 
  

	16.	Property management costs 

These comprise the costs for property management with technical and commercial support. 

 

	17.	Costs for a lightning protection system 

  

	18.	Costs for parking facilities 

These comprise costs for operating, cleaning and maintenance of parking facilities. 

 

	19.	Operational electricity costs 

These comprise operational electricity costs for the common building sections and facilities, to the extent they are not borne by the
users themselves or are included in the above-mentioned items. 
  

	20.	Maintenance costs 

 These
comprise the costs for all maintenance work carried out on the property that are not included in the above-mentioned items. 
  

 Page 3 of the Annex to the Lease Agreement of December 21, 2004 

	21.	Other public charges 

  

	22.	Costs 

 of operation

  

	 	a)	of the common aerial system or 

  

	 	b)	the private distribution system connected to a broadband cable network or 

  

	 	c)	of the satellite reception equipment 

  

	23.	Costs for property surveillance and security installations 

These comprise the costs for regular and special monitoring and surveillance measures as well as the costs for manufacturing, installing
and operating security installations. 
  

	24.	Costs for other equipment 

These include operating costs such as those for washing machine and dryer facilities. 

 

	25.	Costs for property service charge accounts 

These comprise the capital cost for the property service charge accounts, including bank service charges, account-keeping fees, interest
charges. 
  

	26.	Other operating costs 

These comprise the operating costs not mentioned in clause 1 to 25, namely operating costs for adjoining buildings, facilities and
installations. 
  

					
	Essen, January 6, 2005	 		 	Mannheim, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]    [Illegible Signature]

	(Lessor)	 		 	 (Lessee)

	 Alters- und Hinterbliebenen-Versorgungsstelle

der Technischen Überwachungs-Vereine (VVaG)

Kurfürstenstraße 56
 45138
Essen
	 		 	

  

 Page 4 of Annex I to the Lease Agreement of December 21, 2004 

 

 

  

 Addendum No. 1 to the Lease Agreement of January 6, 2005/December 22, 2004 

 Object: Janus-Office-Center, 

Josef-Meyer-Str. 3-15, D- 68167 Mannheim, Germany 

between 
 Alters- und Hinterbliebenen
Versicherung der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807 
 represented
by its managing executive board member, Dr. rer. pol. G. Wiedemann, 
 and 

the company 
 Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15 
 68167 Mannheim,
Germany, 
 represented by its general manager, Mr. Jochen Mattis 

- hereinafter referred to as the “Lessee” - 
  

	1.	Amendment of § 1 Rental Property (Translator’s note: Item 1 of the Lease Agreement is called “Leased Object” and not “Rental
Property”.) 

 The rental space shall be extended by 57.65 sqm on the second floor. The ground plan is
attached as Annex 1 to this Addendum. 
  

	3.	Amendment of § 4 Rent, Service Charges and Value-added Tax 

As of February 1, 2006, the rent for the second floor shall be composed of the following: 

 

									
	 Presently occupied office space
	  	171.18 sqm	  	x	  	[...***...]	  	[...***...]
	 New office space
	  	57.65 sqm	  	x	  	[...***...]	  	[...***...]
	 4 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	228.83 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Net sub-total
	  		  		  		  	[...***...]
	 16%VAT.
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total sum gross
	  		  		  		  	[...***...]

  

 Page 1 of the Addendum of December 7, 2005 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessor shall bear the costs for the relocation of electricity and server cables as well as for the fitting of carpet in the newly rented premises.

 The Lessee shall bear the costs for moving the walls. 

 

	 	2.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

					
	Essen, January 30, 2006	 		 	Mannheim, January 13, 2006
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	68167 Mannheim
	45138 Essen	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)
	[stamp: Alters-und Hinterbliebenen-Versicherung] [stamp: Fa. Nitec Pharma GmbH]

 

 Page 2 of the Addendum of December 7, 2005 

 

 

 Annex to the Addendum 

 Addendum No. 2 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

between 
 Alters- und Hinterbliebenen
Versicherung der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807, 

represented by its executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim, Germany, 

represented by its managing director, Dr. Achim Schäffler 

- hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

As o February 1, 2007, the rental space on the second floor shall be expanded by 214.17 sqm. The Lessee will thus occupy the complete
second floor. The overall space will amount to 443 sqm. 
  

	2.	Amendment to § 4 Term of Lease and Termination 

As of February 1, 2007, the lease for the complete second floor shall be extended by another two years until January 31, 2009
[changed Jaas] 
  

	3.	Amendment to § 5 Rent 

As of February 1, 2007 the rent fort he second floor is composed as follows: 

 

									
	Basic rent for the office space on the 2nd floor	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
	Underground parking spaces 125, 126,127,128	  		  		  		  	[...***...]
	Parking spaces No. 33+32	  		  		  		  	[...***...]
		  		  		  		  	 
	Basic rent total	  		  		  		  	[...***...]
	Advance payment of service charges	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
	Net total: rent including heating	  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total amount
	  		  		  		  	[...***...]
		  		  		  		  	 

  

 Page 1 of the Addendum No. 2 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the installation of the electricity and server cables as well as for the demolition of the added wall. 

 

	 	2.	The Lessor shall bear the costs for the fitting of carpet in the newly rented premises. 

 

	 	3.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, January 3, 2007
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Jpseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 2 of the Addendum No. 2 AHV/Nitec 

 Addendum No. 3 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

between 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler, 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

As of April 1, 2008, the rental space shall be expanded by 247.29 sqm on the sixth floor. 

Thus, the floor space will amount to a total of 690.29 sqm (second and sixth floor). 

 

	2.	Amendment to § 5 Rent 

As of April 1, 2008, the rent shall be composed of the following: 

 

											
	 Basic rent office space on the 2nd floor
	  	443.00 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Underground parking spaces 125,126,127,128,132,133
	  		  		  		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 
	 Basic rent total
	  		  		  		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
		  		  		  		  		  	 
	 Net total: rent including heating
	  		  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  		  	[...***...]
	 Total amount
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 

  

 Page 1 of the Addendum No. 3 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the paintwork and the cleaning of the carpet in the offices on the sixth floor. 

 

	 	2.	The Lessor shall replace the carpet in those offices in which the carpet is heavily worn out. 

 

	 	3.	The Lessor shall bear the costs for a dishwasher. 

  

	 	4.	The furniture on the sixth floor shall be transferred to the company Nitec Pharma free of charge. 

 

	 	5.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, April 4, 2008
			
	 Alters- und Hinterbliebenen-Versicherung der
	 		 	Fa. Nitec Pharma GmbH
	 Technischen Überwachungs-Vereine WaG
	 		 	Joseph-Meyer-Str. 13-15
	 Kronprinzenstr. 30
	 		 	
			
	 45128 Essen
	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

 Annex I: Ground plan of the sixth floor

 Annex II: Underground parking spaces and parking spaces on the first floor 

 

 Page 2 of the Addendum No. 3 AHV/Nitec 

 

 

 Annex I to the Addendum No. 3 

 7.1.5 

Addendum No. 4 to the Lease Agreement of January 6, 2005 / December 22, 2004 

Object: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

between 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 4 Term of Lease and Termination 

The lease of the whole rented space shall be extended until December 31, 2010. 

 

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005/December 22, 2004, along with all addendums shall remain in force without change. 
  

					
	 Essen, September 24, 2008
	 		 	Mannheim, September 18, 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 	(Lessee)

  

 Page 1 of the Addendum No. 4 AHV/Nitec 

 Addendum No. 5 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, D-68167 Mannheim 

between 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

As of April 1, 2009, the Lessee shall in addition rent a store room on the first floor. 

 

	2.	Amendment to § 5 Rent 

Thus, as of April 1, 2009 the monthly rent payment shall amount to the following: 

 

									
	 Basic rent for the office space on the 2nd floor
	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	  	x	  	[...***...]	  	[...***...]
	 storage area on the 1st floor
	  	18.50 sqm	  	x	  	[...***...]	  	[...***...]
	 Underground parking spaces 125, 126,127,128,132,133
	  		  		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Basic rent total
	  		  		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
	 Net total: rent including heating
	  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  	[...***...]

 

 ***Confidential Treatment Requested 

 

			
	Page 1 of the Addendum No. 5 AHV/Nitec	 	

									
	 Total amount
	  		  		  		  	[...***...]
		  		  		  		  	 

  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005 / December 22, 2004, together will all addendums, shall remain in force without change. 
  

					
	Essen, March 12, 2009	 		  	Mannheim, March 12, 2009
			
	Alters- und Hinterbliebenen-Versicherung der	 		  	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-VereineVVaG	 		  	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		  	
			
	45128 Essen	 		  	68167 Mannheim
			
	 [Illegible Signature]
	 		  	 [Illegible Signature]

	(Lessor)	 		  	(Lessee)

  

 Page 2 of the Addendum No. 5 AHV/Nitec 

 7.1.4 

Parking Space 

Lease Agreement 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 

between 
 Alters- und Hinterbliebenen
Versicherung der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 represented by its
managing executive board member, Dr. rer. pol. G. Wiedemann, 
 and 

the company 
 Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15 
 68167 Mannheim

 represented by its managing director, Mr Jochen Mattis, 

- hereinafter referred to as the “Lessee” - 

 

	1.	Leased Object 

 As of
August 1, 2007, the Tenant shall rent the following parking spaces in Joseph-Meyer-Str. 13-15, 68167 Mannheim: 
  

							
	 Parking spaces No. 10 +11
	  	x	  	[...***...]	  	[...***...]
	 + 16% VAT
	  		  		  	[...***...]
	 Overall rent for parking spaces per month
	  		  		  	[...***...]

  

	2.	Termination 

 The Lease
Agreement may be terminated by either party by giving one month’s notice. 
  

					
	Filderstadt, August 7, 2007	 		 	Mannheim, July 11, 2007
			
	[stamp: TÜV SÜD Immobilien Service GmbH]	 		 	[stamp: Nitec Pharma GmbH]
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

			
		 	***Confidential Treatment Requested

 ***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 

and 230.406. 

7.1.3 

MIETVERTRAG 

über Gewerberäume 

Zwischen 
 Alters- und
Hinterbliebenen-Versorgungsstelle der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstraße 58 
 45138 Essen

 -Vermieter 
 UST ID: DE 11 98 24807

 und 
 Firma 

Nitec Pharma GmbH 
 -Mieter- 

UST ID: 37009/52183 
 wird nachfolgender
Vertrag geschlossen: 

 MIETVERTRAG FÜR BÜRO- UND
VERWALTUNGSFLÄCHEN 
 INHALT und ANLAGEN 

 

					
	 Seite
	  	 Inhalt

	1	  	Inhaltsverzeichnis
			
	3	  	§ 1	  	 Mietsache

	3	  	§ 2	  	 Benutzung der Mietsache

			
	4	  	§ 3	  	 Ausstattung der Mieträume

	4	  	§ 4	  	 Mietzeit, Kündigung

			
	5	  	§ 5	  	 Mietzins

			
	6	  	§ 6	  	 Umsatzsteuer

	6	  	§ 7	  	 Änderung des Mietzinses

			
	7	  	§ 8	  	 Zahlung des Mietzinses

	7	  	§ 9	  	 Übergabe und Zustand der Mietsache

	7	  	§ 10	  	 Gebrauchsüberlassung an Dritte

			
	8	  	§ 11	  	 Instandhaltung und Instandsetzung

	8	  	§ 12	  	 Versicherungen

			
	9	  	§ 13	  	 Beschilderung / Reklameanlagen

	9	  	§ 14	  	 Objektbewachung und Sicherheitseinrichtungen

			
	10	  	§ 15	  	 Mängel der Mietsache / Gegenansprüche

	10	  	§ 16	  	 Veränderungen der Mietsache durch den Mieter

	10	  	§ 17	  	 Veränderungen der Mietsache durch den Vermieter

			
	11	  	§ 18	  	 Betreten der Mietsache

	11	  	§ 19	  	 Vermieterpfandrecht/Sicherheitsleistung

			
	12	  	§ 20	  	 Beendigung des Mietverhältnisses

			
	13	  	§ 21	  	 Sonstige Vereinbarungen

			
	Anlage I	  		  	 Aufstellung der Betriebs- und Nebenkosten

	Anlage II	  		  	 Grundrisszeichnungen der Mietflächen

 § 1 - Mietsache 
  

	1.1	Der Vermieter ist Eigentümer der Liegenschaft Joseph-Meyer-Straße 13-15, 68167 Mannheim. 

 

	1.2	 Der Vermieter vermietet an den Mieter Büroflächen in dem vorstehend beschriebenen Gebäude im 1. Obergeschoss mit insgesamt 171,18
m2, darin enthalten sind Haupt-und Nebennutzflächen
und die damit verbundenen Verkehrs- und Funktionsflächen. 

 Der beigefügte Lageplan ist Bestandteil
des Mietvertrages (Anlage II). 
  

	1.3	Solltgen sich bei nachträglicher Vermessung der Mietflächen eine Abweichung von der angegebenen Mietfläche ergeben, ist keine der Parteien berechtigt,
von diesem Vertrag zurückzutreten, ihn zu kündigen oder eine Änderung des Mietzinses zu verlangen. Die angegebenen Flächen sind zugrunde zu legen, soweit es nach den Bestimmungen dieses Vertrages auf die Größe der
vermieteten Flächen ankommt. 

  

	1.4	Die Vermietung erfolgt zur Nutzung als Bürobetrieb. 

Eine Änderung dieses Nutzungszweckes ist nur mit schriftlicher Genehmigung des Vermieters zulässig. Etwaige
Genehmigungserklärungen des Vermieters werden stets, auch wenn dies nicht nochmals ausdrücklich gesagt ist, vorbehaltlich einer etwa erforderlichen behördlichen Genehmigung zur Nutzungsänderung erteilt, deren Beschaffung dem
Mieter auf eigene Kosten obliegt und die dem Vermieter nachzuweisen ist. 
 § 2 - Benutzung der Mietsache 

 

	2.1	Die Mietsache wird zu dem in Ziff. 1.4 genannten Nutzungszweck durch den Mieter gemietet. 

 

	2.2	Der Vermieter übernimmt keine Gewähr dafür, dass der vorgesehene Betrieb des Mieters in der Mietsache öffentlich-rechtlich zulässig ist. Der
Mieter hat auf seine Kosten sämtliche Voraussetzungen für seinen Betrieb zu schaffen und während der Mietzeit aufrechtzuerhalten. Auflagen der Gewerbeaufsicht oder anderer Stellen hat der Mieter auf eigene Kosten zu erfüllen,
auch soweit es sich urn Raumbezogene Auflagen handelt. 

 Die GüItigkeit dieses Mietvertrages ist
unabhängig von einer etwa erforderlichen behördlichen Zulassung der gewerblichen Tätigkeit des Mieters. 
  

	2.3	Der Mieter verpflichtet sich, für die Dauer dieses Vertrages seinen vorgesehenen Betrieb in den Mieträumen aktiv zu betreiben und entsprechend seiner
Betriebsart geöffnet bzw. besetzt zu halten (Betriebspflicht). 

  

	2.4	Der Vermieter räumt dem Mieter keinerlei Konkurrenzschutz ein. 

 

 Seite 33 des Mietvertrages vom 21.12.2004 

	2.5	Vor der Aufstellung von Maschinen, schweren Gegenständen, anderen Anlagen und Einrichtungen in den Mieträumen hat sich der Mieter über die zulässige
Bela-stungsgrenze der Stockwerksdecken beim Vermieter zu erkundigen und seine schriftliche Zustimmung einzuholen. Für Schäden, die durch Nichtbeachtung dieser Bestimmungen eintreten, haftet der Mieter. Führen solche Anlagen und
Einrichtungen des Mieters zu nachteiligen Auswirkungen auf das Gebäude (Erschütterungen, Risse usw.) oder zu Nachteilen oder Unzuträglichkeiten (z. B. Lärm, Staub, störende Gerüche etc.) der Mitbenutzer im Gebäude,
so kann der Vermieter die Zustimmung widerrufen und vom Mieter Unterlassung verlangen. 

  

	2.6	Zur Anmietung gehört auch das Recht des freien Zugangs und der freien Zufahrt zur Mietsache. 

§ 3 - Ausstattung und Übergabe der Mieträume durch den Vermieter 

 

	3.1	Der Zustand und die Ausstattung der Mietsache, wie sie steht und liegt, ist dem Mieter bekannt. 

 

	3.2	Die Mietsache wird dem Mieter spätestens Januar 2005 übergeben. Von der Übergabe ist ein Protokoll zu erstelien. 

§ 4 - Mietzeit und Kündigung 
  

	4.1	Das Mietverhältnis beginnt am 01. Januar 2005 und wird auf die Dauer von 1,5 Jahren bis zum 30.06.2006 abgeschlossen. Bei Beendigung des Mietverhältnisses
findet § 568 BGB für die Vertragsparteien keine Anwendung. 

  

	4.2	Während der Dauer des Mietverhältnisses ist die ordentliche Kündigung ausge-schlossen. Das Recht zur außerordentlichen fristlosen Kündigung
aus wichtigem Grund beider Parteien bleibt unberührt. Ein wichtiger außerordentlicher Kündigungsgrund für den Vermieter liegt insbesondere vor, wenn 

 

	 	a)	der Mieter mit mehr als einer Monatsmiete in Rückstand gerät oder die vereinbarte Sicherheitsleistung nicht in der nach diesem Vertrag vorgesehenen Zeit,
Höhe und Art gestellt hat; 

  

	 	b)	der Mieter ohne Zustimmung des Vermieters die Mietsache oder Teile davon baulich verändert oder zu anderen als im Vertrag bestimmten Zwecken benutzt, insbesondere
Dritten zum Gebrauch überlässt bzw, untervermietet; 

  

	 	c)	der Mieter seine Zahlungen einstellt, es zur Einleitung eines gerichtlichen oder außergerichtlichen Vergleichs—oder Konkursverfahrens über sein
Vermögen—kommen lässt oder die eidesstattliche Versicherung über sein Vermögen ableisten muß; 

  

 Seite 34 des Mietvertrages vom 21.12.2004 

	 	d)	der Mieter in derselben Sache trotz zweimaliger schriftlicher Abmahnung die Vertragsbedingungen nicht einhält. 

 

	4.3	Dem Mieter wird die Option eingeräumt, das Vertragsverhältnis nach Ablauf der unter Punkt 4.1 geregelten Mietvertragslaufzeit um ein, zwei oder drei Jahre zu
verlängem. Nimmt der Mieter von seinem Optionsrecht Gebrauch, so hat er dies in schriftlicher Form dem Vermieter 6 Monate vor jeweiligem Ablauf des Mietverhältnisses mitzuteilen. Die Kündigung hat 6 Monate vor dem jeweiligen Ablauf zu
erfolgen. 

  

	4.5	Soweit der Mieter eine natürliche Person ist, wird das vorzeitige Kündigungsrecht gemäß § 569 BGB hiermit ausgeschlossen.

 § 5 Mietzins 
  

	5.1	Der Mietzins setzt sich für die Grundmietzeit vom 01.01.05 – 30.06.05 monatlich wie folgt zusammen: 

 

									
	 Bürofläche
	  	171,18 
m2	  	x	  	[...***...]	  	[...***...]
	 3 Tiefgaragensteliplätze
	  		  		  		  	[...***...]
	 Nebenkostenvorauszahlung
	  	171,18 
m2	  	x	  	[...***...]	  	[...***...]
					
	 Zwischensumme netto
	  		  		  		  	[...***...]
	 Mehrwertsteuer 16 %
	  		  		  		  	[...***...]
					
	 Summe brutto gesamt
	  		  		  		  	[...***...]

Sollte der Mieter die in § 4 vereinbarte Option über 1 Jahr ausüben, bleibt der Mietzins in Höhe
von [...***...] bestehen, bei 2 jähriger Dauer reduziert sich der Mietzins pro
m2 auf [...***...,] bei 3 jähriger Dauer auf
[...***...] pro m2. 

 

	5.2	Zusätzlich zur Grundmiete übernimmt der Mieter alle für die Mietsache bei ihm direkt anfallenden Betriebskosten (z. B. Strom, Gas, Wasser, Telefon- und
andere Kommunikationskosten) sowie sämtliche Betriebs- und Nebenkosten des Hauses. Betriebs- und Nebenkosten sind alle in der Anlage I zu diesem Vertrag aufgeführten Kosten sowie alle etwaigen künftig entstehenden Kosten, die
durch Gesetz, Verordnung, Ortssatzung oder auf sonstiger Grundlage künftig neu für das Mietobjekt eingeführt werden. Bei der Aufstellung der Betriebs- und Nebenkosten gemäß Anlage I handelt es sich daher um eine
beispielhafte und nicht um eine abschließende Aufzählung möglicher anfallender Kosten. 

  

	5.3	Diese Betriebs- und Nebenkosten werden vom Vermieter auf den Mieter umgelegt und mit ihm abgerechnet. Bei mehreren Mietem im Gebäude bestimmt der Vermieter den
Umlagemaßstab (Verteilungsschlüssel) nach seinem Ermessen, soweit zwingende gesetzliche Bestimmungen dies vorschreiben, gemäß diesen Bestimmungen. Grundsätzlich richtet sich der Verteilungsschlüssel nach dem Anteil
der vermietbaren Fläche an der Gesamtfläche. 

  

  

***Confidential Treatment Requested 

Seite 5 des Mietvertrages vom 21.12.2004 

	5.4	Die Abrechnung erfolgt jährlich durch den Vermieter spätestens bis zum 15.12. des Folgejahres. Endet das Mietverhäitnis während einer
Abrechnungsperiode, wird die Abrechnung im Rahmen der nächstfolgenden Jahresabrechnung vorgenommen. 

  

	5.5	Erhöhen sich die Betriebskosten oder sind Erhöhungen sicher zu erwarten (z. B. durch Ankündigung kommunaler Gebührenerhöhungen), so ist der
Vermieter berechtigt, eine entsprechende Erhöhung der Vorauszahlungen zu verlangen. 

 § 6 Umsatzsteuer

  

	6.1	Zuzüglich zur vereinbarten Grundmiete einschließlich der Betriebs- und Nebenkosten hat der Vermieter die Umsatzsteuer in ihrer jeweiligen gesetzlichen
Höhe zu entrichten. Der Mieter versichert, dass er die Mieträume ausschließlich für Umsätze verwendet oder zu verwenden beabsichtigt, welche den Vorsteuerabzug beim Vermieter nicht ausschließen. Sollte der Mieter
entgegen dieser Zusicherung die Mieträume nicht ausschließlich für solche Umsätze verwenden, die den Vorsteuerabzug nicht ausschließen (steuerschädliche Verwendung), so erhöht sich die Grundmiete
einschließlich Nebenkosten im Zeitraum der umsatzsteuerschädlichen Verwendung um denjenigen Betrag, welcher der jeweiligen auf die Grundmiete zuzüglich Betriebs- und Nebenkosten zu entrichtenden Umsatzsteuer entspricht.

  

	6.2	Auf Verlangen des Vermieters ist der Mieter verpflichtet, die ausschließliche Verwendung der Mietsache für Umsätze, die den Vorsteuerabzug nicht
ausschließen, nachzuweisen. Der Mieter hat den bevorstehenden Beginn einer solchen steuerschädlichen Verwendung dem Vermieter unverzüglich anzuzeigen und ihm jeglichen Schaden zu ersetzen, der diesem aus einer Verletzung der
Anzeigepflicht erwächst; hierzu zählt insbesondere jeder Schaden beim Vermieter daraus, dass dieser nach Beginn der steuerschädlichen Verwendung Umsatzsteuern an das Finanzamt abführt, obwohl nunmehr eine umsatzsteuerfreie
Vermietung vorliegt. Schadensersatzansprüche dieser Art verjähren nicht vor Ablauf von 6 Monaten nach bestandskräftiger Feststellung durch eine Finanzbehörde oder ein Finanzgericht, dass der Vermieter nicht oder nicht mehr zum
Vorsteuerabzug berechtigt ist. 

 § 7 - Änderung des Mietzinses 

 

	7.1	 Ändert sich der vom Statistischen Bundesamt festgesteilte Preisindex für die Lebenshaltung aller privaten Haushalte (Verbraucherpreisindex
für Deutschland) (Basisjahr 2000 = 100 Punkte) gegenüber dem Stand 30.06.2009 oder gegenüber der letzten Mietanpassung um mehr als
[...***...], so ändert sich jeweils die in
§ 5 vereinbarte Grundmiete prozentual entsprechend. Die Änderung wird von dem Monatsersten an wirksam, der auf die Veränderung folgt. 

 

  

***Confidential Treatment Requested 

Seite 36 des Mietvertrages vom 21.12.2004 

	7.2.	Sollte diese Wertsicherungsklausel nicht gem. § 4 der Preisklauselverordnung als genehmigt gelten, so verpflichten sich die Parteien eine dem wirtschaftlichen Sinn
und Zweck am ehesten entsprechende Wertsicherungsklausel zu vereinbaren, die nach den dann geltenden Vorschriften genehmigungsfähig ist. 

§ 8 - Zahlung des Mietzinses 

Die Mietzinszahlung beginnt am 01.01.2005. 

Der Mietzins ist spätestens bis zum 3. Werktag eines jeden Monats auf das Konto der [...***...] 

§ 9 - Übergabe der Mietsache / Zustand der Mietsache 
  

	9.1	Die Übergabe der Mietsache ist vorgesehen für den Zeitpunkt des Mietbeginns gemäß § 4.1. Den verbindlichen Übergabetermin teilt der
Vermieter dem Mieter schriftlich so früh wie möglich mit. 

 Ausstehende Restarbeiten, wie z. B. die
völlige Herstellung der Außenanlagen und/oder die Mängelbeseitigung, hindem die Übernahme der Mietsache nicht. 
  

	9.2	Anlässlich der Übergabe wird von den Parteien ein Übergabeprotokoll gefertigt, das den Zustand der Mietsache und etwaige Mängel zu diesem Zeitpunkt
dokumentiert. 

 Übergabeprotokoll festgestellte Mängel hat der Vermieter innerhalb einer angemessenen
Nachfrist zu beseitigen. 
 § 10 - Gebrauchsüberlassung an Dritte 

 

	10.1	Jede ganze oder teilweise Gebrauchsüberlassung an Dritte, insbesondere die Untervermietung der Mietsache, bedarf vor Abschluss der Zustimmung des Vermieters. Ein
Kündigungsrecht des Mieters wegen Verweigerung dieser Zustimmung ist ausgeschlossen. Sind für eine anderweitige Nutzung, welche der Vermieter genehmigt hat, im Rahmen einer solchen Gebrauchsüberlassung Behördenauflagen zu
erfüllen, gehen auch diese ausschließlich zu Lasten des Mieters. 

  

	10.2	Der Vermieter kann die Zustimmung zur Untervermietung aus wichtigem Grund widerrufen. Dies darf jedoch nicht zur Unzeit geschehen. 

 

  

***Confidential Treatment Requested 

Seite 37 des Mietvertrages vom 21.12.2004 

 § 11 – Instandhaltung/Instandsetzung/Schönheitsreparaturen/Haftung für Schäden

  

	11.1	Dem Mieter obliegen die Schönheitsreparaturen sowie die sonstigen Instandhaltungs- und Instandsetzungsarbeiten innerhalb der Mieträume, soweit die
Schäden durch den Gebrauch des Mieters entstanden sind (Abnutzung, Verschleiß, Beschädigung durch den Mieter oder seine ErfüIlungsgehilfen). 

§ 12 - Versicherungen 
  

	12.1	Die übliche Gebäudeversicherung (Feuer, Sturm, Leitungswasser, Extended Coverage) und die Gebäudehaftpflichtversicherung werden vom Vermieter zu Lasten
der Betriebs- und Nebenkosten abgeschlossen. Durch den Mieter vorgenommene Ein-, Aus- oder Umbauten des Mietobjektes sind nicht von der Gebäudeversicherung gedeckt. Der Mieter ist verpflichtet, diese Ein-, Aus- oder Umbauten auf eigene Kosten
selbst zu versichem. 

  

	12.2	Der Mieter ist verpflichtet, eine ausreichende Betriebshaftpflicht- sowie eine Einbruchdiebstahlversicherung und eine ausreichende Versicherung der eingebrachten
Einrichtungen und Sachen gegen alle Beschädigungen auf eigene Kosten abzuschließen und für die Dauer der Mietzeit aufrechtzuerhalten. 

  

	12.3	Der Vermieter hat das Recht, sich von dem ordnungsgemäßen Abschluss der gem. § 12.2 vom Mieter abzuschließenden Versicherungen und deren
Aufrechterhaltung durch Einsichtnahme in die Versicherungsverträge zu überzeugen. Dies gilt ebenso über die Zahlung der Erstprämie der jeweiligen Versicherung. 

§ 13 - Beschilderung Reklameanlagen 
  

	13.1	Dem Mieter ist das Anbringen von Namens- und Firmenschildem im Eingangsbereich und im Bereich der Eingangstüren zu ihren Mieträumen an den vom Vermieter
hierfür vorgesehenen Stellen gestattet. Sonstige Gebäudeteile oder Flächen des Anwesens sind nicht mitvermietet; Reklameanlagen, Warenautomaten, Schaukästen, Verkaufsstände, Schilder, Markisen, Antennen u. ä.
dürfen daher dort nicht angebracht oder aufgestellt werden. 

  

	13.2	Darüber hinausgehende Reklameanlagen oder andere Einrichtungen gemäß § 13.1, welche der Mieter anbringen oder aufstellen will, bedürfen der
vorherigen, schriftlichen Genehmigung des Vermieters, die auch mit Auflagen und Kostentragungspflichten verbunden werden kann. 

  

	13.3	Der Vermieter behält sich vor, die Beschilderung oder das Anbringen von Reklameanlagen und sonstigen Vorrichtungen einheitlich nach einem gemeinschaftlichen
Werbekonzept für das Anwesen zu gestalten. Diesem einheitlichen Konzept hat sich der Mieter mit seiner Beschilderung und seinen Reklameanlagen und sonstigen Vorrichtungen anzupassen. Die Kosten der Beschilderung trägt der Mieter.

  

 Seite 38 des Mietvertrages vom 21.12.2004 

 

 § 14 - Objektbewachung und Sicherheitseinrichtungen 

 

	14.1	Falls die Parteien für das Objekt Bewachungsmaßnahmen als notwendig betrachten, sind diese vom Mieter zu dulden, soweit sie ihm rechtzeitig angezeigt werden.
Der Mieter verpflichtet sich, die hierfür anfallenden Kosten zu tragen, bei mehreren Mietem anteilig nach dem Umlagemaßstab für andere Betriebs- und Nebenkosten. 

 

	14.2	Dies gilt entsprechend für den Fall der Installation von Sicherheitseinrichtungen durch den Vermieter. Die Installation von Sicherheitseinrichtungen innerhalb der
Mieträume durch den Mieter bedarf der vorherigen Zustimmung des Vermieters. 

 §15 Mängel der
Mietsache/Gegenansprüche 
 Es gelten die gesetzlichen Regelungen 

§ 16 - Veränderungen der Mietsache durch den Mieter 
  

	16.1	Veränderungen an und in der Mietsache, insbesondere Um- und Einbauten, Installationen und dergleichen dürfen nur mit schriftlicher Einwilligung des Vermieters
vorgenommen werden. 

  

	16.2	Gas-, Elektro- und sonstige Geräte dürfen nur in dem Umfang an das vorhandene Leitungsnetz angeschlossen werden, als die für die Mietsache vorgesehene
Belastung nicht überschritten wird. 

 § 17 - Veränderungen der Mietsache durch den Vermieter 

 

	17.1	Der Vermieter darf Ausbesserungen und bauliche Veränderungen, die zur Erhaltung oder zur Abwendung drohender Gefahren oder zur Beseitigung von Schäden oder
zur Verbesserung der Mietsache und ihrer Vermietung notwendig oder zweckmäßig werden, auch ohne Zustimmung des Mieters vornehmen. Der Mieter hat die in Betracht kommenden Räume zugänglich zu halten und darf die Ausführungen
der Arbeiten nicht hindern oder verzögem; andernfalls hat er den dadurch entstehenden Schaden zu ersetzen. 

  

	17.2	Auf die betrieblichen Belange des Mieters ist angemessene Rücksicht zu nehmen. Insbesondere hat der Vermieter die Durchführung solcher Arbeiten rechtzeitig
anzukündigen. Die Ankündigungspflicht gilt nicht bei Gefahr im Verzug. 

  

 Seite 9 des Mietvertrages vom 21.12.2004 

 

 § 18 - Betreten der Mietsache 

Der Mieter hat während der üblichen Geschäftszelt zu gewährleisten, dass der Vermieter oder seine Beauftragten,
Sachverständige und Interessenten die Mietsache zum Zwecke der Neuvermietung, des Verkaufes, zur Feststellung des Zustandes oder zur Vornahme von Arbeiten jederzeit - nach Voranmeldung - betreten und besichtigen können. 

In Fällen von Gefahr im Verzug ist das Betreten der Mietsache zu jeder Tages- und Nachtzeit durch den Mieter zu ermöglichen.

 § 19 - Pfandrecht des Vermieters / Sicherheitsleistung 

 

	19.1	Der Vermieter hat für alle auch künftigen Forderungen aus diesem Vertrag ein Pfandrecht an den eingebrachten Sachen des Mieters (Büromöbel,
Maschinen und sonstige Gegenstände der Geschäftsausstattung und Einrichtung). 

  

	19.2	Bei Pfändung eingebrachter Sachen durch Dritte verpflichtet sich der Mieter, den Vermieter unverzüglich unter Vorlage der Unterlagen von den Einzelheiten und
dem Umfang der Pfändung zu benachrichtigen. 

  

	19.3	Der Mieter leistet zur Absicherung aller Ansprüche des Vermieters aus diesem Mietvertrag und seiner Beendigung spätestens 14 Tage vor Mietbeginn
gemäß § 4.1 eine Sicherheitsleistung (Bürgschaft) in Höhe von [...***...] zuzüglich vereinbarter oder geschätzter Betriebs- und Nebenkosten und zuzüglich der jeweiligen gesetzlichen
Mehrwertsteuer, in Höhe von 

 [...***...] 

[...***...] 

Diese Sicherheitsleistung ist in Form einer unbedingten, unwiderruflichen, unbefristeten und selbstschuldnerlschen Bürgschaft einer
in der Bundesrepublik Deutschland ansässigen Großbank zu erbringen, bei welcher die bürgende Bank auf das Recht zur Anfechtung, zur Aufrechnung, zur Hinterlegung und die Rechte und Einreden aus §§ 768, 776 BGB verzichtet
und sich zur Zahlung auf erstes Anfordern durch den Vermieter verpflichtet hat. 
 Die Bürgschaft darf über die
Bestimmung hinaus, dass die Bürgschaftsverpflichtung mit Rückgabe der Bürgschaftsurkunde durch den Vermieter an die Bürgen oder dann, wenn nach Beendigung des Mietverhältnisses sämtliche Verpflichtungen des Mieters aus
dem Mietverhältnis erfüllt sind, zurückzugeben ist, gegebenenfalls um vom Vermieter in Anspruch genommene Beträge gemindert, keine weiteren Bedingungen und Einschränkungen enthalten. 

 

  

***Confidential Treatment Requested 

Seite 10 des Mietvertrages vom 21.12.2004 
  

	19.4	Kommt es während der Mietzeit zu einer Veränderung der Grundmiete und/oder der Betriebs- und Nebenkosten um mindestens [...***...] des bisherigen
monatlichen Gesamtbetrages, so ist der Mieter auf Verlangen des Vermieters zu einer entsprechenden Anpassung seiner Sicherheitsleistung binnen 14 Tagen ab Aufforderung verpflichtet. 

§ 20 - Beendigung des Mietverhältnisses 
  

	20.1	Bei Beendigung des Mietverhältnisses hat der Mieter die Mietsache gereinigt in ordnungsgemäßem Zustand mit sämtlichen Schlüsseln an den
Vermieter herauszugeben. Spätestens bis zum Zeitpunkt des Mietendes hat der Mieter ferner in jedem Fall notwendige, die ihm nach § 11 obliegenden Schönheitsreparaturen, Instandhaltungs- und Instandsetzungsmaßnahmen
vollständig durchzuführen; andernfalls kann der Vermieter auf Kosten des Mieters ohne nochmalige Mahnung und Fristsetzung solche Reparaturen und Maßnahmen anstelle des Mieters auf dessen Kosten selbst durchführen.

  

	20.2	Einrichtungen, mit welchen der Mieter die Mietsache versehen hat und alle von ihm etwa während der Mietzeit vorgenommenen Änderungen der Mietsache,
insbesondere Ein- und Umbauten, einschließlich Beschilderungen, Reklameanlagen und sonstiger Vorrichtungen gemäß § 13 dieses Vertrages, hat der Mieter auf seine Kosten vor Auszug fachgerecht zu entfemen und den
ursprünglichen Zustand der Mietsache wieder herzustellen. 

 Die bei Mietbeginn in den Mieträumen
befindlichen Verkabelungen, der eingebaute Serverraum und die im Serverraum befindliche Klimaanlage ist nach dem Auszug des Mieters nicht zurückzubauen. 

Der Vermieter kann die Ausübung dieses Wegnahmerechts durch Zahlung einer angemessenen Entschädigung abwenden, die sich nach dem
Zeitwert der Einrichtung bestimmt. 
  

 Seite 11 des Mietvertrages vom 21.12.2004 

 

 § 21 - Sonstige Vereinbarungen 

 

	21.1	Erfüllungsort und Gerichtsstand für alle sich aus diesem Vertrag ergebenden Verpflichtungen ist Mannheim. 

 

	21.2	Durch die Ungültigkeit einer oder mehrerer Bestimmungen dieses Vertrages wird die Gültigkeit der übrigen nicht betührt Für den Fall der
Nichtigkeit einzelner Bestimmungen sind die Parteien verpflichtet, an ihrer SteIle eine solche Regelung zu treffen, die der ursprünglichen vorgestellten mit rückwirkender Kraft am nächsten kommt. 

 

	21.3	Nebenabreden, Änderungen, Ergänzungen und Aufhebung des Vertrages sind nur wirksam, wenn sie schriftlich vereinbart werden. Das gleiche gilt für Zusagen
und Zustimmungen aller Art. Auf die Schriftform kann nur schriftlich und ausdrücklich verzichtet werden. Insbesondere bedürfen der Schriftform alle im Rahmen dieses Vertrages anfallenden Erklärungen, wie Kündigungen,
Zustimmungen, Genehmigungen und dergleichen. 

  

	21.4	Der in den Büroräumen eingebaute Serverraum, inklusive der technischen Einrichtungen (z.B. zusätzliche Verkabelung, Klimaanlage) sowie die
zusätzliche Türschließanlage incl. der Installationen verbleibt beim Auszug des Mieters in den Räumlichkeiten. 

  

	21.5	Auf die zu diesem Vertrag gehörenden AnIagen I - II wird Bezug genommen. 

 

					
	Essen, den 06.01.2005	 		 	Munich, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  

 Seite 12 des Mietvertrages vom 21.12.2004 

 

 Anlage I zum Mietvertrag AHV / Fa. Nitec Pharma 

AUFSTELLUNG DER BETRIEBS- UND NEBENKOSTEN 

Betriebskosten und Nebenkosten sind nachstehende Kosten, die dem Eigentümer durch das Eigentum am Grundstück oder durch den
Bestimmungsmäßigen Gebrauch des Gebäudes oder der Wirtschaftseinheit, der Nebengebäude, Anlagen, Einrichtungen und des Grundstückes laufend entstehen, es sei denn, dass sie üblicherweise vom Mieter außerhalb der
Miete unmittelbar getragen werden: 
  

	1.	Die laufenden öffentlichen Lasten des Grundstücks 

Hierzu gehört namentlich die Grundsteuer. 
  

	2.	Die Kosten der Wasserversorgung 

Hierzu gehören die Kosten des Wasserverbrauchs, die Grundgebühren und die Zählermiete, die Kosten der Verwendung von
Zwischenzählern und die Kosten des Betriebs. 
  

	3.	Die Kosten der Entwässerung 

Hierzu gehören die Gebühren für die Benutzung einer öffentlichen Entwässerungs-anlage, inklusiv der Einleitung
von Regenwasser und die Kosten des Betriebs. 
  

	4.	Die Kosten der Heizungsanlage 

Hierzu gehören die Kosten des Betriebs und der Reinigung 

 

	 	a)	der Heizungsanlage sowie die Kosten der Verwendung einer messtechnischen Ausstattung zur Verbrauchserfassung. Heizungsanlagen können z.B. zentrale Heizungsanlage
oder mit der Warmwasserversorgungsanlage verbundene Heizungsanlagen, zentrale Brennstoffversorgungsanlagen oder Etagenheizungen sein; 

  

	 	b)	die Kosten der Versorgung mit Fernwärme und die Kosten des Betriebes 

  

	 	c)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

 

 Seite 13 des Mietvertrages vom 21.12.2004 

 

	5.	Die Kosten der Warmwasserversorgung 

Hierzu gehören die Kosten des Betriebs und der Reinigung 

 

	 	a)	der Warmwasserversorgungsanlagen, wie z. B. zentrale oder mit der Heizungs-anlage verbundene Warmwasserversorgungsanlagen; 

 

	 	b)	die Kosten der Versorgung mit Femwarmwasser und die Kosten des Betriebs der zugehörigen Hausanlagen; 

 

	 	c)	der Warmwassergeräte und Geräte zur Verbrauchserfassung; 

  

	 	d)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

 

	6.	Die Kosten der Klima-, Be- und Entlüftungsanlagen 

Hierzu gehören die Kosten des Betriebs 
  

	7.	Die Kosten des maschinellen Personen- oder Lastenaufzuges 

Hierzu gehören die Kosten des Betriebsstroms, die Kosten der Beaufsichtigung, der Bedienung, Überwachung und Pflege der Anlage,
der regelmäßigen Prüfung ihrer Betriebsbereitschaft und Betriebssicherheit einschl. der Einstellung durch einen Fachmann und die Kosten der Reinigung. 
  

	8.	Die Kosten der Straßenreinigung und MüIlabfuhr 

Hierzu gehören die für die öffentliche Straßenreinigung und Müllabfuhr zu entrichtenden Gebühren und die
Kosten entsprechender nicht öffentlicher Maßnahmen. 
  

	9.	Die Kosten der Reinigung und Ungezieferbekämpfung 

Zu den Kosten der Reinigung gehören u. a. die Kosten für die Säuberung des Objektes, u. a. der Zugänge,
Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume, Waschküchen, Technikräumen, Aufzugsfahrkörbe sowie Fassaden bzw. die Glasreinigung. 

 

	10.	Die Kosten der Außenanlagen 

Hierzu gehören die Kosten der Pflege gartnerisch angelegtër Flächen einschl. der Erneuerung von. Pflanzen und
Gehölzen, der Pflege von Spielplätzen einschl. der Erneuerung von Sand. Des Weiteren die Pflege, Reinigung, Räumung und Streuung von Plätzen, Zugängen und Zufahrten, die dem nicht öffentlichen Verkehr dienen.

  

 Seite 14 des Mietvertrages vom 21.12.2004 

 

	11.	Die Kosten der Beleuchtung 

Hierzu gehören die Kosten des Stroms für die Außenbeleuchtung und die Beleuchtung der allgemeinen Gebäudetelle des
Objektes, wie z.B. Zugänge, Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume, Waschküchen und Technikräume. 
  

	12.	Die Kosten der Schornsteinreinigung 

Hierzu gehören die Kehrgebühren nach der maßgebenden Gebührenordnung. 

 

	13.	Die Kosten der Versicherungen 

Hierzu gehören die Kosten aller Versicherungen, die für das Objekt abgeschlossen werden, wie Gebäudeversicherung mit
“all-risk”-Deckung, Glasversicherung, Haft-pflichtversicherung für das Gebäude, den Oltank, den Aufzug, sowie Mietverlustver-sicherung. 
  

	14.	Die Kosten für den Hauswart, des Portiers bzw. Pförtners und des sonstigen für den Betrieb des Gebäubes benötigten Personals

 Hierzu gehören u.a. die Personalnebenkosten sowie Sondervergütungen. 

 

	15.	Die Kosten für Beschilderung und Werbeanlagen 

Hierzu gehören die Kosten für die Anbringung und den Betrieb von Beschilderungs- und Reklameanlagen. Zu Beschilderungsanlagen
gehören z. B. Firmen-, Namens-, Lage- und Informationsbeschilderungen. 
  

	16.	Die Kosten des Objektmanagements 

Hierzu gehören die Kosten des Objektmanagements mit technischer und kaufmännischer Betreuung. 

 

	17.	Die Kosten der Blilzschutzanlage 

  

	18.	Die Kosten der Garagen 

Hierzu gehören die Kosten des Betriebs und die Reinigung und Wartung der Garagenanlagen. 

 

	19.	Die Kosten des Betriebsstroms 

Hierzu gehören die Kosten des Betriebsstroms für die gemeinschaftlichen Gebäudeteile und -anlagen, soweit sie nicht von den
Nutzem selbst getragen werden oder in den vorgenannten Punkten beinhaltet sind. 
  

	20.	Die Kosten für Wartungen 

Hierzu gehören die Kosten für alle Wartungsarbeiten, die im Objekt durchgeführt werden und nicht in den vorgenannten
Punkten beinhaltet sind. 
  

 Seite 15 des Mietvertrages vom 21.12.2004 

 

	21.	Sonstige öffentliche Gebühren 

  

	22.	Die Kosten 

 des Betriebs

  

	 	a)	der Gemeinschafts-Antennenanlage bzw. 

  

	 	b)	der mit einem Breitbandkabelnetz verbundenen privaten Verteileranlage bzw. 

 

	 	c)	der Satellitenempfangsanlage 

  

	23.	Die Kosten für die Objektbewachung und Sicherheitseinrichtungen 

Hierunter gehören die Kosten für regelmäßige und besondere Be- und Überwachungsmaßnahmen sowie die Kosten
für Fertigung, Anbringung und Betrieb für Sicherheitseinrichtungen. 
  

	24.	Die Kosten sonstiger Geräte 

Hierzu gehören die Kosten des Betriebs z. B. maschineller Wasch- und Trockeneinrichtungen. 

 

	25.	Die Kosten der Mietnebenkostenkonten 

Hierzu gehören die Kapitalkosten der Mietnebenkostenkonten, wie z. B. Bearbeitungsgebühren, Kontogebühren, Sollzinsen.

  

	26.	Sonstige Betriebskosten 

Das sind die in den Nummern 1 bis 25 nicht genannten Betriebskosten, namentlich die Betriebskosten von Nebengebäuden, Anlagen und
Einrichtungen. 
  

					
	Essen, den 06.01.2005	 		 	Mannheim, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)
	 Alters- und Hinterbliebenen-Versorgungsstelleder

Technischen Überwachungs-Vereine (VVaG)
	 		 	
	Kurfürstenstraße 56 - 45138 Essen	 		 	

  

 Seite 16 des Mietvertrages vom 21.12.2004 

 

 

 

 Nachtrag Nr. 1 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center,

Josef-Meyer-Str. 13-15, 68167 Mannheim 

zwischen 
 Alters- und Hinterbliebenen
Versicherung der 
 Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 
 und 

Firma 
 Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15 
 68167 Mannheim

 vertreten durch den Geschäftsführer Herr Jochen Mattis 

- nachstehend Mieterin genannt 
  

	1.	Änderung zu § 1 Mietgegenstand 

Die Mietfläche wird um 57,65
m2 im 1. OG erweitert. Der Grundriss ist als Anlage 1 zum
Nachtrag beigelegt. 
  

	3.	Änderung zu § 4 Mietzins, Nebenkosten und Mehrwertsteuer 

Der Mietzins für das 1. OG setzt ab dem 01.02.2006 wie folgt zusammen: 

 

									
	Bürofläche seither	  	171,18 
m2	  	x	  	[...***...]	  	[...***...]
	Bürofläche neu	  	57,65 
m2	  	x	  	[...***...]	  	[...***...]
	4 Tiefgaragenstellplätze	  		  		  		  	[...***...]
	Nebenkostenvorauszahlung	  	228,83 
m2	  	x	  	[...***...]	  	[...***...]
	Zwischensumme netto	  		  		  		  	[...***...]
	Mehrwertsteuer 16 %	  		  		  		  	[...***...]
	Summe brutto gesamt	  		  		  		  	[...***...]

  

  

***Confidential Treatment Requested 
  

			
	 Seite 1 des Nachtrags vom 07.12.2005
	  	

  

	4.	Sonstiges 

  

	 	1.	Der Vermieter übernimmt auf seine Kosten die Umverlegung der Strom- und Serverleitungen, sowie das Teppichverlegen der neu angemieteten Räume.

 Der Mieter übernimmt die Kosten der Verschiebung der Wande. 

 

	 	2.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den 30.01.06	 		 	Mannheim, den 13.01.06
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	
	45138 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVAG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  

 Seite 2 des Nachtrags vom 07.12.2005 

 

 

 

 Nachtrag Nr. 2 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

zwischen 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 UST ID: DE 11 98 24807 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

Die Mietfläche wird ab 01.02.2007 um 214,17
m2 im 1. OG erweitert. Somit wird das komplette 1. OG von
der Mieterin belegt. Die Gesamtfläche beträgt 443
m2. 

 

	2.	Änderung zu § 4 Mietzeit und Kündigung 

Das Mietverhältnis veriängert sich ab 01.02.2007 für das komplette 1. OG um weitere 2 Jahre bis zum 31.01.2009

  

	3.	Änderung zu § 5 Mietzins 

  

									
	 Kaltmiete Bürofläche 1. OG
	  	443 
m2	  	á	  	[...***...]	  	[...***...]
	 Tiefgaragenplätze 125,126,127,128
	  		  		  		  	
	 Stellplätze Nr. 33+32
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Summe Kaltmiete
	  		  		  		  	[...***...]
	 + Nebenkostenvorauszahlung
	  	443 
m2	  	á	  	[...***...]	  	
		  		  		  		  	 
	 Summe Warmmiete netto

+ 19 % MwSt.
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Summe gesamt
	  		  		  		  	[...***...]
		  		  		  		  	 

  

  

***Confidential Treatment Requested 

Seite 1 des Nachtrags Nr. 2 AHV/Nitec 
  

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Verlegung der Strom- und Serverleitungen, sowie den Abbruch der eingezogenen Wand. 

 

	 	2.	Der Vermieter übernimmt die Kosten für das Verlegen von Teppich in den neu angemieteten Räumen. 

 

	 	3.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

							
	Essen, den	 	  
	 		 	Mannheim, den 03. January 2007
			
	Alters- und Hinterbilebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine-VVaG-	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  

 Seite 2 des Nachtrags Nr. 2 AHV/Nitec 

 

 Nachtrag Nr. 3 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

zwischen 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

Die Mietfläche wird ab 01.04.2008 um 247,29
m2 im 5. OG erweitert. 

Somit beträgt die Gesamtfläche neu 690,29
m2 (1. und 5. OG) 

 

	2.	Änderung zu § 5 Mietzins 

Der Mietzins für setzt sich ab 01.04.08 wie folgt zusammen: 

 

									
	 Kaltmiete Bürofläche 1. OG
	  	443,00 
m2	  	á	  	[...***...]	  	[...***...]
	 Kaltmiete Bürofläche 5. OG
	  	247,29 
m2	  	á	  	[...***...]	  	[...***...]
	 Tiefgaragenplätze 125,126,127,128,132,133
	  		  		  		  	[...***...]
	 Stellplätze Nr. 32+33+10+11+2
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Summe Kaltmiete
	  		  		  		  	[...***...]
	 + Nebenkostenvorauszahlung
	  	690,29 
m2	  	á	  	[...***...]	  	[...***...]
		  		  		  		  	 
	 Summe Warmmiete netto
	  		  		  		  	[...***...]
	 + 19 % MwSt.
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Summe gesamt
	  		  		  		  	[...***...]
		  		  		  		  	 

  

  

***Confidential Treatment Requested 

Seite 1 des Nachtrags Nr. 3 AHV/Nitec 
  

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Malerarbeiten und Teppichreinigung in den Büroräumen im 5 OG. 

 

	 	2.	In Büroräumen, in welchen der Teppichboden sehr stark abgenutzt ist, ersetzt der Vermieter den Teppichboden. 

 

	 	3.	Der Vermieter übernimmt die Kosten einer Geschirrspülmaschine. 

  

	 	4.	Die Möbel im 5. OG gehen kostenfrei auf die Firma Nitec Pharrna über. 

 

	 	5.	Samtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den                     	 		 	Mannheim, den 04, April 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Meiterin)

 Anlage I: Grundriss 5. OG 

Anlage II: Stellplatze Tiefgarage und Erdgeschoss 
  

 Seite 2 des Nachtrags Nr. 2 AHV/Nitec 

 

 

 

  

 Seite 3 des Nachtrags Nr. 2 AHV/Nitec 

 

 

 

  

 Seite 5 des Nachtrags Nr. 2 AHV/Nitec 

 

 

 

  

 Seite 6 des Nachtrags Nr. 2 AHV/Nitec 

 

 7.1.5 

Nachtrag Nr. 4 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center,

Josef-Meyer-Str. 13-15, 68167 Mannheim 

Zwischen 
 Alters-und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 4 Mietzeit und Kündigung 

Das Mietverhältnis verlängert sich für die gesamte angemietete Fläche bis zum 31.12.2010. 

 

	2.	Sonstiges 

 Sämtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 nebst allen Nachträgen gelten unverändert fort. 
  

					
	Essen, den 24.09.2008	 		 	Mannheim, den 18 SEPT 2008
			
	 Alters- und Hinterbliebenen-Versicherung der

Technischen Überwachungs-Vereine VVaG

Kronprinzenstr. 30
	 		 	 Fa. Nitec Pharma GmbH

Joseph-Meyer-Str. 13-15

			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  

 Seite 1 des Nachtrags Nr. 4 AHV/Nitec 

 

 Nachtrag Nr. 5 zum Mietvertrag vom 06.01.2005/22.12.2004 

Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 

Zwischen 
 Alters- und
Hinterbliebenen-Versicherung 
 der Technischen Uberwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer pol. G Wiedemann and Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geshäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietsache 

Die Mieterin mietet ab 01.04.2009 zusätzlich einen Lagerraum im Erdgeschoss an. 

 

	2.	Änderung zu § 5 Mietzins 

Somit ended sich die monatliche Mietzahlung ab 01.04.09 wie folgt: 

 

											
	Kaltmiete Burof1äche 1. OG	  	443,00 
m2	 	á	  	[...***...]	  	[...***...]	  	€
	Kaltmiete Buroffäche 5 OG	  	247,29 
m2	 	á	  	[...***...]	  	[...***...]	  	€
	Lagerfläche EG	  	18,50
m2	 	á	  	[...***...]	  	[...***...]	  	€
	Tiefgaragenplätze 125,126,127,128,132,133	  		 		  		  	[...***...]	  	€
	Stellplatze Nr 32+33+10+11+2	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Kaltmiete	  		 		  		  	[...***...]	  	€
	+ Nebenkostenvorauszahlung	  	690,29 
m2	 	á	  	[...***...]	  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Warmmiete netto	  		 		  		  	[...***...]	  	€
	+ 19 % MwSt.	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe gesamt	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	

  

  

***Confidential Treatment Requested 
  

	3,	Sonstiges 

 Samtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01 2005/ 22 12.2004 nebst allen Nachirägen gelten unverandert fort 
  

					
	Essen, den 12.3.09	 		 	Mannheim, den 12.03.09
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVaG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  

 Seite 2 des Nachtrags Nr. 5 AHV/Nitec 

 

 7.1.4 

Mietvertrag über 

Stellplätze 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 

Zwischen 
 Alters-und Hinterbliebenen

 Versicherung der 
 Technischen
Uberwachungsvereine VVaG 
 Kurfurstenstr. 56 

45138 Essen 
 UST ID: DE 11 98 24807 

Vertreten durch den Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschaftsführer Herr Jochen Mattis 
 -nachstehend Mieterin genannt- 

 

	1.	Mietobjekt 

 Der Mieter
mietet ab 01.08.2007 in der Joseph-Meyer-Str. 13-15, 68167 Mannheim nachstehende Stellpätze an: 
  

							
	Stellplatz Nr. 10+11	  	á	  	[...***...]	  	[...***...]
	+ 16% MwSt.	  		  		  	[...***...]
		  		  		  	 
	monatliche Stellplatzmiete gesamt	  		  		  	[...***...]

  

	2.	Kündigung 

 Der
Mietvertrag kann von beiden Parteien mit einer Frist von 1 Monat gekündigt werden. 
  

  

***Confidential Treatment Requested 
  

					
	Filderstadt, den 07.08.07	 		 	Mannheim, den [Illegible]
			
	TUV SUD Immobillien Servico GmbH	 		 	 Nitec Pharma GmbH

Joseph-Meyer-Strafle 13-15
 68167
Mannheim

	[Illegible]	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  

 2.Amended and Restated Executive Employment Agreement

 Exhibit 10.22 

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT 

AGREEMENT BY AND BETWEEN 

HORIZON PHARMA, INC., HORIZON PHARMA USA, INC. AND 

TIMOTHY P. WALBERT 

This Amended and Restated Executive Employment Agreement (hereinafter referred to as the “Agreement”), is entered into
effective July 27, 2010 (the “Effective Date”) by and between Horizon Pharma, Inc., a Delaware corporation, and its wholly owned subsidiary, Horizon Pharma USA, Inc., a Delaware corporation, each having a principal place of
business at 1033 Skokie Boulevard, Suite 355 Northbrook, IL, 60062, (hereinafter referred to together as the “Company”), and Timothy P. Walbert, an individual residing at 107 Prairie Avenue, Park Ridge, Illinois 60068,
domiciled in the State of Illinois (hereinafter referred as to the “Executive”). This Agreement amends and supersedes in its entirety the Amended and Restated Employment Agreement entered into by and between Horizon Pharma
USA, Inc. (formerly Horizon Therapeutics, Inc.) and Executive on December 26, 2008 (the “Prior Agreement”). 

RECITALS 

WHEREAS, the Company is a duly organized Delaware corporation, with its principal place of business within the State of Illinois,
and is in the business of developing and marketing prescription medication; and 
 WHEREAS, Executive is domiciled
within the State of Illinois and is highly skilled and experienced in the business of developing and marketing health care related products and services; and 

WHEREAS, the Company desires assurance of the continued association and services of the Executive in order to continue to
retain the Executive’s experience, skills, abilities, background and knowledge, and is willing to continue to engage the Executive’s services on the terms and conditions set forth in this Agreement; and 

WHEREAS, Executive desires to be in the continued employ of the Company, and is willing to accept such continued employment on the
terms and conditions set forth in this Agreement. 
 AGREEMENT 

 

	 	1.	Employment. 

 1.1
Term. The Company hereby agrees to employ the Executive, and the Executive hereby accepts employment by the Company, upon the terms and conditions set forth in this Agreement. Executive’s original date of hire was June 30, 2008 (the
“Hire Date”) Executive’s employment shall be governed under the terms set 
  

 1 

 
forth in this Agreement beginning on the Effective Date and shall continue until it is terminated pursuant to Section 4 herein (hereinafter referred to as the
“Term”). 
 1.2 Title. The Executive shall have the title of President and Chief Executive
Officer ( hereinafter referred to as “CEO”) of the Company and shall serve in such other capacity or capacities commensurate with his position as President and CEO as the Board of Directors of the Company
(hereinafter referred to as the “Board”) may from time to time prescribe. The Executive was named to the Board of the Company within thirty (30) days following the commencement of his employment.

 1.3 Duties. The Executive shall do and perform all services, acts or things necessary or advisable to
manage and conduct the business of the Company and shall have the authority and responsibilities which are generally associated with the position of President and CEO, including being responsible for the Company’s strategy and operations. The
Executive shall report to the Board. 
 1.4 Policies and Practices. The employment relationship between the
Parties shall be governed by this Agreement and the policies and practices established by the Company and the Board. In the event that the terms of this Agreement differ from or are in conflict with the Company’s policies or practices or the
Company’s Employee Handbook, this Agreement shall control. 
 1.5 Location. The Executive shall perform the
services the Executive is required to perform pursuant to this Agreement in the headquarter office for the Company in the Northbrook, Illinois area. The Company may from time to time require the Executive to travel temporarily to other locations
outside of the Northbrook, Illinois area in connection with the Company’s business. 
  

	 	2.	Loyalty of Executive. 

2.1 Loyalty. During the Executive’s employment by the Company, the Executive shall devote the Executive’s business
energies, interest, abilities and productive time to the proper and efficient performance of Executive’s duties under this Agreement. The Executive is permitted to serve on the boards of directors of two companies (or up to four companies if
permitted by the Board), so long as they do not compete with the Company.  
 2.2 Exclusive
Employment. Except with the prior written consent of the Board, Executive shall not, during the term of this Agreement, undertake or engage in any other employment, occupation or business enterprise, other than ones in which Executive is
a passive investor. The Board and Company hereby provides authorization to Executive to continue to serve as President and CEO of IDM Pharma until no later than August 31, 2008 and to serve on the board of directors of IDM Pharma (potentially
as Executive Chair) and NeuMedics on an ongoing basis. Executive may engage in any civic and not-for-profit activities so long as such activities do not materially interfere with the performance of his duties hereunder or present a conflict of
interest with the Company. 
  

 2 

 2.3 Agreement not to Participate in Company’s Competitors. During the Term of
this Agreement, the Executive agrees not to acquire, assume or participate in, directly or indirectly, any position, investment or interest known by Executive to be adverse or antagonistic to the Company, its business or prospects, financial or
otherwise or in any company, person or entity that is, directly or indirectly, in competition with the business of the Company or any of its affiliates. 
  

	 	3.	Compensation to Executive. 

3.1 Base Salary. The Company shall pay the Executive a base salary at the initial annualized rate of four hundred fifty thousand
six hundred twenty-five dollars and no cents ($450,625.00) per year, subject to standard deductions and withholdings, or such higher rate as may be determined from time to time by the Board or the compensation committee thereof (hereinafter referred
to as the “Base Salary”). Such Base Salary shall be paid in accordance with the Company’s standard payroll practice. Payments of salary installments shall be made no less frequently than once per month. Executive’s Base Salary
will be reviewed annually each December, and Executive shall be eligible to receive a salary increase (but not decrease) annually in an amount to be determined by the Board or the compensation committee thereof in its sole and exclusive discretion.
Once increased, the new salary shall become the Base Salary for purposes of this Agreement and shall not be reduced without the Executive’s written consent. Any reduction in the Base Salary of the Executive, without his written consent, shall
be deemed Good Reason as set forth in and subject to Section 4.5.2 of this Agreement. 
 3.2 Discretionary Bonus.
Provided the Executive meets the conditions stated in this Section 3.2, the Executive shall be eligible for an annual discretionary bonus (hereinafter referred to as the “Bonus”) with a target amount of fifty percent (50%) of the
Executive’s Base Salary, subject to standard deductions and withholdings, based on the Board’s determination, in good faith, and based upon the Executive’s individual achievement and company performance objectives as set by the
Board or the compensation committee thereof, of whether the Executive has met such performance milestones as are established for the Executive by the Board or the compensation committee thereof, in good faith, in consultation with the Executive
(hereinafter referred to as the “Performance Milestones”). The Performance Milestones will be based on certain factors including, but not limited to, the Executive’s performance and the Company’s financial performance. The
Executive’s Bonus target will be reviewed annually and may be adjusted by the Board or the compensation committee thereof in its discretion, provided however, that the Bonus target may only be reduced upon Executive’s written consent. The
Executive must be employed on the date the Bonus is awarded to be eligible for the Bonus, subject to the termination provisions thereof. Bonuses shall be paid during the calendar year following the calendar year for which such Bonus was earned.

 3.3 Stock Options. Subject to the Company’s 2005 Stock Plan (hereinafter referred to as the “Plan”),
the Executive was as soon as practicable after the Executive’s Hire Date granted an option to purchase two hundred eighty eight thousand nine hundred-twenty (288,920) shares of the Company’s Common Stock (the “Option”).

  

 3 

 
The exercise price of the Option was the fair market value of the Company’s Common Stock on the date of the grant, as determined by the Board based on its most recent 409(A) determination.
The Option vests over a period of four years, with twenty-five percent of the Options vesting on the one-year anniversary of the Executives start date with the Company and the remaining Options vesting ratably monthly over the following three years.
The Executive will have the right to exercise the Option with respect to unvested shares, subject to the Company’s right to repurchase such shares on termination of the Executive’s employment by the Company at the original purchase price,
with such repurchase right lapsing according to the vesting schedule set forth above. The Option is subject to the terms of the Plan and is an incentive stock option to the maximum extent permitted by law. In the event that the terms of this
Agreement differ with the Company’s policies or practices set out in its Plan, this Agreement shall control; provided, however, that the Options will remain subject to any additional acceleration of vesting and any other terms more beneficial
to Executive that may be provided in the Plan or applicable option agreements that are not otherwise provided pursuant to this Agreement. 

3.4 Discretionary Grants. At least one time per year, including following any private equity financing within one year after the
Hire Date, the Board shall consider, in good faith, whether to grant additional equity awards to the Executive. In February 2010, Executive was granted a stock option under the Plan to purchase up to three hundred six thousand and ninety eight
(306,098) shares of the Company’s Common Stock. 
 3.5 Legal Review. Upon the Executive’s submission of
appropriate itemized proof and verification of reasonable and customary legal fees incurred by the Executive in obtaining legal advice associated with the review, preparation, approval, and execution of this Agreement, the Company shall pay for such
legal fees subject to receipt of appropriate proof and verification of such legal fees no later than ninety (90) days after such expenses are incurred by Executive. The Company agrees to pay all reasonable legal fees pursuant to
Section 3.5 of this Agreement within thirty (30) days of receipt an invoice for legal services from the Executive and/or his attorneys. 

3.6 Changes to Compensation. The Executive’s compensation may be changed from time to time by mutual agreement of the
Executive and the Company. In the event that the Executive’s base salary is materially decreased without his written consent, said decrease will be Good Reason for the Executive to terminate the Agreement as set forth in and subject to
Section 4.5.2 of this Agreement. 
 3.7 Taxes. All amounts paid under this Agreement to the Executive by the Company
will be paid less applicable tax withholdings and any other withholdings required by law or authorized by the Executive. 

3.8 Benefits. The Executive shall, in accordance with Company policy and the terms of the applicable plan documents, be eligible
to participate in benefits under any executive benefit plan or arrangement which may be in effect from time to time and made available to the Company’s executives or key management 

 

 4 

 
employees, provided, however, that the Executive shall be entitled to at least four (4) weeks of paid vacation annually. 

 

	 	4.	Termination. 

 4.1
Termination by the Company. The Executive’s employment with the Company may be terminated only under the following conditions: 

4.1.1 Termination for Death or Disability. The Executive’s employment with the Company shall terminate effective upon the
date of the Executive’s death or “Complete Disability” (as defined in Section 4.5.1), provided, however, that this Section 4.1.1 shall in no way limit the Company’s obligations to provide such reasonable accommodations
to the Executive and/or his heirs as may be required by law. 
 4.1.2 Termination by the Company For Cause. The Company
may terminate the Executive’s employment under this Agreement for “Cause” (as defined in Section 4.5.3) by delivery of written notice to the Executive specifying the Cause or Causes relied upon for such termination, provided that
such notice is delivered within two (2) months following the occurrence or discovery of any event or events constituting “Cause”. Any notice of termination given pursuant to this Section 4.1.2 shall effect termination as of the
date of the notice or such date as specified in the notice. The Executive shall have the right to appear before the full Board before any termination for Cause becomes effective and binding upon the Executive. 

4.1.3 Termination by the Company Without Cause. The Company may terminate the Executive’s employment under this
Agreement at any time and for any reason or no reason subject to the requirements set out in Section 4.4 of this Agreement. Such termination shall be effective on the date the Executive is so informed or as otherwise specified by the Company,
pursuant to notice requirements set forth in Section 6 of this Agreement . 
 4.2 Termination By The Executive. The
Executive may terminate his employment with the Company at any time and for any reason or no reason, including, but not limited, to the following conditions: 

4.2.1 Good Reason. The Executive may terminate his employment under this Agreement for “Good Reason” (as defined below
in Section 4.5.2) by delivery of written notice to the Company specifying the Good Reason relied upon by the Executive for such termination in accordance with the requirements of such section. 

4.2.2 Without Good Reason. The Executive may terminate the Executive’s employment hereunder for other than Good Reason upon
thirty (30) days written notice to the Company. 
 4.3 Termination by Mutual Agreement of the Parties. The
Executive’s employment pursuant to this Agreement may be terminated at any time upon 
  

 5 

 
a mutual agreement in writing of the Parties. Any such termination of employment shall have the consequences specified in such mutual agreement. 

4.4 Compensation to Executive Upon Termination. 

4.4.1 Death or Complete Disability. If the Executive’s employment shall be terminated by death or Complete Disability as
provided in Section 4.1.1, the Company shall pay to Executive, and/or Executive’s heirs, all earned but unpaid Base Salary, any earned but unpaid discretionary bonuses for any prior period at such time as bonuses would have been paid if
the Executive remained employed, all accrued but unpaid business expenses, and all accrued but unused vacation time earned through the date of termination at the rate in effect at the time of termination (hereinafter referred to as the “Accrued
Amounts”), less standard deductions and withholdings. The Executive shall also be eligible to receive a pro-rated bonus for the year of termination, as determined by the Board or the Compensation Committee of the Board based on actual
performance and the period of the year he was employed (hereinafter referred to as the “Pro-rata Bonus”), less standard deductions and withholdings, to be paid as a lump sum within thirty (30) days after the date of termination.

 4.4.2 With Cause or Without Good Reason. If the Executive’s employment shall be terminated by the Company for
Cause, or if the Executive terminates employment hereunder without Good Reason, the Company shall pay the Executive’s Base Salary, accrued but unpaid business expenses and accrued and unused vacation benefits earned through the date of
termination at the rate in effect at the time of termination, less standard deductions and withholdings. 
 4.4.3 Without
Cause or For Good Reason. If the Company terminates the Executive’s employment without Cause or the Executive terminates his employment for Good Reason, the Company shall pay the Accrued Amounts subject to standard deductions and
withholdings, to be paid as a lump sum no later than thirty (30) days after the date of termination. In addition, subject to the limitations stated in this Agreement and upon the Executive’s furnishing to the Company an executed waiver and
release of claims (the form of which is attached hereto as Exhibit A) (the “Release”) within the applicable time period set forth therein, but in no event later than forty-five days following termination of employment and permitting such
Release to become effective in accordance with its terms (the “Release Effective Date”), and subject to Executive entering into no later than the Release Effective Date a non-competition agreement to be effective during the Severance
Period, substantially similar to Section 2.3, and continuing to abide by its terms during the Severance Period, the Executive shall be entitled to: 

(i) the equivalent of the Executive’s annual Base Salary in effect at the time of termination for a period of twelve
(12) months following the date of termination (“hereinafter referred to as the “Severance Period”), less standard deductions and withholdings, to be paid during the Severance Period according to the Company’s regular payroll
practices, subject to any delay in payment required by Section 4.6 in connection with the Release Effective Date; 
  

 6 

 (ii) Executive’s Target Bonus in effect at the time of termination, or if none,
the last Target Bonus in effect for Executive, less standard deductions and withholdings, to be paid in a lump sum no later than ten (10) days after the Release Effective Date; and 

(iii) in the event the Executive timely elects continued coverage under COBRA, the Company will continue to pay the same portion
of Executive’s COBRA health insurance premium as the percentage of health insurance premiums that it paid during the Executive’s employment, including any amounts that Company paid for benefits to the qualifying family members of the
Executive, up until the earlier of either (i) the last day of the Severance Period or, (ii) the date on which the Executive begins full-time employment with another company or business entity which offers comparable health insurance
coverage to the Executive. 
 4.4.4 Equity Award Acceleration. 

(i) Not in Connection With a Change in Control. In the event that the Executive’s employment is
terminated without Cause or for Good Reason before the first anniversary of the Hire Date, and Section 4.4.4 (ii) below does not apply, the vesting of the Option, as set out in Section 3.3 of this Agreement, shall be accelerated as of
the date of termination such that the number of Option shares equal to
 
1/48th
 the number of Option shares multiplied by the number of full months of Executive’s employment shall be deemed vested and immediately exercisable by the Executive. 

(ii) In Connection With a Change in Control. In the event that the Executive’s employment is terminated without Cause or for
Good Reason within the ninety (90) days immediately preceding or during the eighteen (18) months immediately following a Change in Control of the Company (as defined in Section 4.5.4 of this Agreement), the vesting of the Option shall
be fully accelerated such that on the effective date of such termination one hundred percent (100%) of the Option and any other equity award shares granted to Executive prior to such termination shall be fully vested and immediately exercisable
by the Executive. 
 (iv) Release and waiver. Any equity vesting acceleration pursuant to this Section 4.4.4 shall
be conditioned upon and subject to the Executive’s delivery to the Company of a fully effective Release in accordance with the terms specified by Section 4.4.3 hereof, and such vesting acceleration benefit shall be in addition to the
benefits provided by Section 4.4.3 hereof. 
 4.5 Definitions. For purposes of this Agreement, the following terms
shall have the following meanings: 
 4.5.1 Complete Disability. “Complete Disability” shall mean the
inability of the Executive to perform the Executive’s duties under this Agreement, whether with or without reasonable accommodation, because the Executive has become permanently disabled within the meaning of any policy of disability income
insurance covering employees of the Company then in force. In the event the Company has no 
  

 7 

 
policy of disability income insurance covering employees of the Company in force when the Executive becomes disabled, the term “Complete Disability” shall mean the inability of the
Executive to perform the Executive’s duties under this Agreement, whether with or without reasonable accommodation, by reason of any incapacity, physical or mental, which the Board, based upon medical advice or an opinion provided by a licensed
physician, determines to have incapacitated the Executive from satisfactorily performing all of the Executive’s usual services for the Company, with or without reasonable accommodation, for a period of at least one hundred eighty
(180) days during any twelve (12) month period that need not be consecutive. 
 4.5.2 Good Reason.
“Good Reason” for the Executive to terminate the Executive’s employment hereunder shall mean the occurrence of any of the following events without the Executive’s consent: 

(i) a material reduction in the Executive’s duties, authority, or responsibilities relative to the duties, authority, or
responsibilities in effect immediately prior to such reduction; 
 (ii) the relocation of the Executive’s office to
a point more than fifty (50) miles from the Executive’s Northbrook, Illinois based work location that requires a material increase in Executive’s one-way driving distance; and 

(iii) a material reduction by the Company of the Executive’s base salary or annual target Bonus opportunity, without the
written consent of the Executive, as initially set forth herein or as the same may be increased from time to time pursuant to this Agreement. 

Provided, however that, such termination by the Executive shall only be deemed for Good Reason pursuant to the foregoing definition if (i) the
Company is given written notice from the Executive within sixty (60) days following the first occurrence of the condition that he considers to constitute Good Reason describing the condition and the Company fails to satisfactorily remedy such
condition within thirty (30) days following such written notice, and (ii) the Executive terminates employment within thirty (30) days following the end of the period within which the Company was entitled to remedy the condition
constituting Good Reason but failed to do so. 
 4.5.3 Cause. “Cause” for the Company to terminate
Executive’s employment hereunder shall mean the occurrence of any of the following events, as determined reasonably and in good faith by the Board or a committee designated by the Board: 

(i) the Executive’s gross negligence or willful failure to substantially perform his duties and responsibilities to the
Company or willful and deliberate violation of a Company policy; 
 (ii) the Executive’s conviction of a felony
involving his commission of any act of fraud, embezzlement or dishonesty against the Company or 
  

 8 

 
involving moral turpitude that is likely to inflict or has inflicted material injury on the business of the Company; 

(iii) the Executive’s unauthorized use or disclosure of any proprietary information or trade secrets of the Company or any
other party that the Executive owes an obligation of nondisclosure as a result of the Executive’s relationship with the Company; and 

(iv) the Executive’s willful and deliberate breach of the obligations under this Agreement that causes material
injury to the business of the Company. 
 4.5.4 Change in Control. For purposes of this Agreement, “Change in
Control” means: (i) a sale of all or substantially all of the assets of the Company; (ii) a merger or consolidation in which the Company is not the surviving entity and in which the holders of the Company’s outstanding voting
stock immediately prior to such transaction own, immediately after such transaction, securities representing less than fifty percent (50%) of the voting power of the entity surviving such transaction or, where the surviving entity is a
wholly-owned subsidiary of another entity, the surviving entity’s parent; (iii) a reverse merger in which the Company is the surviving entity but the shares of Common Stock outstanding immediately preceding the merger are converted by
virtue of the merger into other property, whether in the form of securities of the surviving entity’s parent, cash or otherwise, and in which the holders of the Company’s outstanding voting stock immediately prior to such transaction own,
immediately after such transaction, securities representing less than fifty percent (50%) of the voting power of the Company or, where the Company is a wholly-owned subsidiary of another entity, the Company’s parent; or (iv) an
acquisition by any person, entity or group (excluding any employee benefit plan, or related trust, sponsored or maintained by the Company or subsidiary of the Company or other entity controlled by the Company) of the beneficial ownership of
securities of the Company representing at least seventy-five percent (75%) of the combined voting power entitled to vote in the election of Directors; provided, however, that nothing in this paragraph shall apply to a sale of assets, merger or
other transaction effected exclusively for the purpose of changing the domicile of the Company. 
 4.6 Application of
Internal Revenue Code Section 409A. Notwithstanding anything to the contrary set forth herein, any payments and benefits provided under this Agreement (the “Severance Benefits”) that constitute “deferred compensation”
within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively “Section 409A”) shall not
commence in connection with Executive’s termination of employment unless and until Executive has also incurred a “separation from service” (as such term is defined in Treasury Regulation Section 1.409A-1(h) (“Separation From
Service”), unless the Company reasonably determines that such amounts may be provided to Executive without causing Executive to incur the additional 20% tax under Section 409A. 

 

 9 

 It is intended that each installment of the Severance Benefits payments provided for in this
Agreement is a separate “payment” for purposes of Treasury Regulation Section 1.409A-2(b)(2)(i). For the avoidance of doubt, it is intended that payments of the Severance Benefits set forth in this Agreement satisfy, to the greatest
extent possible, the exemptions from the application of Section 409A provided under Treasury Regulation Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9). However, if the Company (or, if applicable, the successor entity thereto)
determines that the Severance Benefits constitute “deferred compensation” under Section 409A and Executive is, on the termination of service, a “specified employee” of the Company or any successor entity thereto, as such
term is defined in Section 409A(a)(2)(B)(i) of the Code, then, solely to the extent necessary to avoid the incurrence of the adverse personal tax consequences under Section 409A, the timing of the Severance Benefit payments shall be
delayed until the earlier to occur of: (i) the date that is six months and one day after Executive’s Separation From Service, or (ii) the date of Executive’s death (such applicable date, the “Specified Employee Initial
Payment Date”), the Company (or the successor entity thereto, as applicable) shall (A) pay to Executive a lump sum amount equal to the sum of the Severance Benefit payments that Executive would otherwise have received through the Specified
Employee Initial Payment Date if the commencement of the payment of the Severance Benefits had not been so delayed pursuant to this Section and (B) commence paying the balance of the Severance Benefits in accordance with the applicable payment
schedules set forth in this Agreement. 
 Notwithstanding anything to the contrary set forth herein, Executive shall receive the
Severance Benefits described above, if and only if Executive duly executes and returns to the Company within the applicable time period set forth therein, but in no event more than forty-five days following Separation From Service, the
Company’s standard form of release of claims in favor of the Company (attached to this Agreement as Exhibit A) and permits the release of claims contained therein to become effective in accordance with its terms. Notwithstanding any other
payment schedule set forth in this Agreement, none of the Severance Benefits will be paid or otherwise delivered prior to the effective date of the Release. Except to the extent that payments may be delayed until the Specified Employee Initial
Payment Date pursuant to the preceding paragraph, on the first regular payroll pay day following the effective date of the Release, the Company will pay Executive the Severance Benefits Executive would otherwise have received under the Agreement on
or prior to such date but for the delay in payment related to the effectiveness of the Release, with the balance of the Severance Benefits being paid as originally scheduled. 

4.7 Application of Internal Revenue Code Section 280G. If any payment or benefit Executive would receive pursuant to a Change
in Control from the Company or otherwise (“Payment”) would (i) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this sentence, be subject to the excise
tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment shall be equal to the Reduced Amount. The “Reduced Amount” shall be either (x) the largest portion of the Payment that would
result in no portion of the Payment being subject to the Excise Tax or (y) the largest portion, up to and including the total, of the Payment, whichever amount, after taking into account all applicable federal, state and

  

 10 

 
local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate), results in Executive’s receipt, on an after-tax basis, of the greater
economic benefit notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount,
reduction shall occur in the manner that results in the greatest economic benefit for Executive. If more than one method of reduction will result in the same economic benefit, the items so reduced will be reduced pro rata. 

In the event it is subsequently determined by the Internal Revenue Service that some portion of the Reduced Amount as determined pursuant
to clause (x) in the preceding paragraph is subject to the Excise Tax, Executive agrees to promptly return to the Company a sufficient amount of the Payment so that no portion of the Reduced Amount is subject to the Excise Tax. For the
avoidance of doubt, if the Reduced Amount is determined pursuant to clause (y) in the preceding paragraph, Executive will have no obligation to return any portion of the Payment pursuant to the preceding sentence. 

Unless Executive and the Company agree on an alternative accounting firm, the accounting firm engaged by the Company for general tax
compliance purposes as of the day prior to the effective date of the Change in Control shall perform the foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group
effecting the Change in Control, the Company shall appoint a nationally recognized accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required
to be made hereunder. 
 The Company shall use commercially reasonable efforts to cause the accounting firm engaged to make the
determinations hereunder to provide its calculations, together with detailed supporting documentation, to Executive and the Company within fifteen (15) calendar days after the date on which Executive’s right to a Payment is triggered (if
requested at that time by you or the Company) or such other time as requested by Executive or the Company. 
 4.8
Indemnification Agreement. The Company and the Executive have previously entered into an indemnification agreement which shall continue to govern the terms of Executive’s employment following the Effective Date, and a copy of which is
attached hereto as Exhibit B. 
 4.9 Confidential Information and Invention Assignment Agreement. The Executive
has previously executed the Company’s Confidential Information and Invention Assignment Agreement the terms of which shall continue to govern the terms of Executive’s employment following the Effective Date, and a copy of which is attached
as Exhibit C. 
  

	 	5.	Assignment and Binding Effect. 

  

 11 

 This Agreement shall be binding upon the Executive and the Company and inure to the benefit
of the Executive and the Executive’s heirs, executors, personal representatives, assigns, administrators and legal representatives. Because of the unique and personal nature of the Executive’s duties under this Agreement, neither this
Agreement nor obligations under this Agreement shall be assignable by the Executive. This Agreement shall be binding upon and inure to the benefit of the Company and a successor, assigns and legal representatives, provided that the Agreement may
only be assigned to an acquirer of all or substantially all of the Company’s assets. Any such successor of the Company will be deemed substituted for the Company under the terms of this Agreement for all purposes. For this purpose,
“successor” means any person, firm, corporation or other business entity which at any time, whether by purchase, merger or otherwise, directly or indirectly acquires all or substantially all of the assets or business of the Company.

  

	 	6.	Notice. 

 For the purposes
of this Agreement, notices, demands, and all other forms of communication provided for in this Agreement shall be in writing and shall be deemed to have been duly given when delivered or (unless otherwise specified) mailed by registered mail, return
receipt requested, postage prepaid, or by confirmed facsimile, addressed as set forth below, or to such other address as any party may have furnished to the other in writing in accordance herewith, except that notices of address shall be
effective only upon receipt, as follows: 
 If to the Company: 

Horizon Pharma, Inc. 

1033 Skokie Boulevard, Suite 355 

Northbrook, IL, 60062 

Attention: Chairman of the Board of Directors 

Fax: 224-383-3001 

If to the Executive: 

Timothy P. Walbert 

107 Prairie Avenue 

Park Ridge, Illinois 60068 

With a Copy to : 

Anthony J. Madonia 

Anthony J. Madonia & Associates, Ltd. 

150 North Wacker Drive, 

Suite 2600 

Chicago, Illinois 60606 

Fax: (312) 578-9303 
  

 12 

 Any such written notice shall be deemed given on the earlier of the date on which such notice is personally
delivered or five (5) days after its deposit in the United States mail as specified above. Either Party may change its address for notices by giving written notice to the other Party in the manner specified in this section. 

 

	 	7.	Choice of Law. 

 This
Agreement shall be governed by the laws of the State of Illinois, without regard to any conflicts of law principals thereof that would call for the application of the laws of any other jurisdiction. The parties consent to the exclusive jurisdiction
and venue of the federal court in the Northern District of Illinois, and state courts located in the state of Illinois, county of Cook. Nothing in this Section 7 limits the rights of the parties to seek appeal of a decision of an Illinois court
outside of Illinois that has proper jurisdiction over the decision of a court sitting in Illinois. 
  

	 	8.	Integration. 

 This
Agreement, including Exhibit A, Exhibit B, Exhibit C and the Plan and applicable stock option agreements contains the complete, final and exclusive agreement of the Parties relating to the terms and conditions of the Executive’s employment and
the termination of Executive’s employment, and supersedes all prior and contemporaneous oral and written employment agreements or arrangements between the Parties. 

 

	 	9.	Amendment. 

 This
Agreement cannot be amended or modified except by a written agreement signed by the Executive and the Company. 
  

	 	10.	Waiver. 

 No term,
covenant or condition of this Agreement or any breach thereof shall be deemed waived, except with the written consent of the Party against whom the wavier is claimed, and any waiver or any such term, covenant, condition or breach shall not be deemed
to be a waiver of any preceding or succeeding breach of the same or any other term, covenant, condition or breach. 
  

	 	11.	Severability. 

 The
finding by a court of competent jurisdiction of the unenforceability, invalidity or illegality of any provision of this Agreement shall not render any other provision of this Agreement unenforceable, invalid or illegal. Such court shall have the
authority to modify or replace the invalid or unenforceable term or provision with a valid and enforceable term or provision, which most accurately represents the Parties’ intention with respect to the invalid, unenforceable, or illegal term or
provision. 
  

	 	12.	Interpretation; Construction. 

The headings set forth in this Agreement are for convenience of reference only and shall not be used in interpreting this Agreement. This
Agreement has been drafted and negotiated by legal counsel representing the Company and the Executive. 
  

 13 

 
The Parties acknowledge that each Party and its counsel has reviewed and revised, or had an opportunity to review and revise, this Agreement, and any rule of construction to the effect that any
ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Agreement. 
  

	 	13.	Execution by Facsimile Signatures and in Counterparts. 

The parties agree that facsimile signatures shall have the same force and effect as original signatures. This Agreement may be executed in
one or more counterparts, each of which shall be deemed an original but all of which together shall constitute one and the same instrument. 
  

 14 

 IN WITNESS WHEREFORE, the parties have signed this Agreement on the date first
written above. 
 COMPANY: 

HORIZON PHARMA, INC. 
 HORIZON PHARMA
USA, INC. 
  

			
	By:	 	
		
	Title:	 	Executive Vice President and CFO

			
		
	Print Name:	 	Robert J. De Vaere
	
	 /S/    ROBERT J.
DE VAERE

		
	Signature:	 	
		
		 	As authorized agent of the Company
	
	  

		
	Date	 	
	
	 EXECUTIVE:
  

TIMOTHY P. WALBERT

	
	 /S/    TIMOTHY P.
WALBERT

	Timothy P. Walbert, individually
	
	  

		
	Date	 	

  

 15 

 EXHIBIT A 

RELEASE AND WAIVER OF CLAIMS 

In consideration of the payments and other benefits set forth in Section
            of the Amended and Restated Employment Agreement dated
                    , 2010, (the “Employment Agreement”), to which this form is attached, I, Timothy P. Walbert,
hereby furnish Horizon Pharma, Inc. and Horizon Pharma USA, Inc. (together the “Company”), with the following release and waiver (“Release and Waiver”). 

In exchange for the consideration provided to me by the Employment Agreement that I am not otherwise entitled to receive, I hereby
generally and completely release the Company and its directors, officers, employees, shareholders, partners, agents, attorneys, predecessors, successors, parent and subsidiary entities, insurers, Affiliates, and assigns from any and all claims,
liabilities and obligations, both known and unknown, that arise out of or are in any way related to events, acts, conduct, or omissions occurring relating to my employment or the termination thereof prior to my signing this Release and Waiver. This
general release includes, but is not limited to: (1) all claims arising out of or in any way related to my employment with the Company or the termination of that employment; (2) all claims related to my compensation or benefits from the
Company, including, but not limited to, salary, bonuses, commissions, vacation pay, expense reimbursements, severance pay, fringe benefits, stock, stock options, or any other ownership interests in the Company; (3) all claims for breach of
contract, wrongful termination, and breach of the implied covenant of good faith and fair dealing; (4) all tort claims, including, but not limited to, claims for fraud, defamation, emotional distress, and discharge in violation of public
policy; and (5) all federal, state, and local statutory claims, including, but not limited to, claims for discrimination, harassment, retaliation, attorneys’ fees, or other claims arising under the federal Civil Rights Act of 1964 (as
amended), the federal Americans with Disabilities Act of 1990, the federal Age Discrimination in Employment Act of 1967 (as amended) (“ADEA”), and the California Fair Employment and Housing Act (as amended). Notwithstanding
the foregoing, this Release and Waiver, shall not release or waive my rights: to indemnification under the articles and bylaws of the Company or applicable law, including without limitations, California Labor Code Sections 2800 and 2802; to payments
under Sections             of the Employment Agreement; under any provision of the Employment Agreement that survives the termination of that agreement; under the California
Workers’ Compensation Act; under any option, restricted share or other agreement concerning any equity interest in the Company; as a shareholder of the Company or any other right that is not waivable under applicable law. 

I also acknowledge that I have read and understand Section 1542 of the California Civil Code which reads as follows: “A general
release does not extend to claims which the creditor does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor.”
I hereby expressly waive and relinquish all rights and 
  

 16 

 
benefits under that section and any law of any jurisdiction of similar effect with respect to any claims I may have against the Company. 

I acknowledge that, among other rights, I am waiving and releasing any rights I may have under ADEA, that this Release and Waiver is
knowing and voluntary, and that the consideration given for this Release and Waiver is in addition to anything of value to which I was already entitled as an executive of the Company. If I am 40 years of age or older upon execution of this Release
and Waiver, I further acknowledge that I have been advised, as required by the Older Workers Benefit Protection Act, that: (a) the release and waiver granted herein does not relate to claims under the ADEA which may arise after this Release and
Waiver is executed; (b) I should consult with an attorney prior to executing this Release and Waiver; and (c) I have twenty-one (21) days from the date of termination of my employment with the Company in which to consider this Release
and Waiver (although I may choose voluntarily to execute this Release and Waiver earlier); (d) I have seven (7) days following the execution of this Release and Waiver to revoke my consent to this Release and Waiver; and (e) this
Release and Waiver shall not be effective until the seven (7) day revocation period has expired unexercised. If I am less than 40 years of age upon execution of this Release and Waiver, I acknowledge that I have the right to consult with an
attorney prior to executing this Release and Waiver (although I may choose voluntarily not to do so); and (c) I have five (5) days from the date of termination of my employment with the Company in which to consider this Release and Waiver
(although I may choose voluntarily to execute this Release and Waiver earlier). 
 I acknowledge my continuing obligations under
my Confidential Information and Inventions Agreement dated                     , 2008. Pursuant to the Confidential Information and Inventions
Agreement I understand that among other things, I must not use or disclose any confidential or proprietary information of the Company and I must immediately return all Company property and documents (including all embodiments of proprietary
information) and all copies thereof in my possession or control. I understand and agree that my right to the payments and other benefits I am receiving in exchange for my agreement to the terms of this Release and Waiver is contingent upon my
continued compliance with my Confidential Information and Inventions Agreement. 
 This Release and Waiver, including my
Confidential Information and Inventions Agreement dated                     , 2008, constitutes the complete, final and exclusive embodiment
of the entire agreement between the Company and me with regard to the subject matter hereof. I am not relying on any promise or representation by the Company that is not expressly stated herein. This Release and Waiver may only be modified by a
writing signed by both me and a duly authorized officer of the Company. 
  

			
	Date:	 	  

		
	By:	 	  

		 	Timothy P. Walbert

  
  

 17

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