Document:

Exhibit 10.26  

 LEASE  

 OF  

 1020 EAST MEADOW CIRCLE  

 PALO ALTO, CALIFORNIA  

 BY AND BETWEEN  

 CALIFORNIA PACIFIC COMMERCIAL CORPORATION,  

 A CALIFORNIA CORPORATION, LANDLORD  

 AND  

 ANACOR PHARMACEUTICALS, INC.  

 A DELAWARE CORPORATION, TENANT  

 

  L E A S E  

        This Lease, dated October 5, 2007, is made and entered into by and between CALIFORNIA PACIFIC COMMERCIAL CORPORATION, a
California corporation ("Landlord"), and ANACOR PHARMACEUTICALS, INC., a Delaware corporation ("Tenant"). 

        Landlord
and Tenant agree as follows: 

        1.    Premises.    

        1.1.    Description.    Landlord hereby leases to Tenant and Tenant hereby leases from Landlord for the term, at the
rental, and upon all of the other terms, covenants and conditions set forth herein, the real property commonly referred to as 1020 East Meadow Circle, City of Palo Alto, County of Santa Clara, State
of California, and more particularly described in Exhibit A attached hereto and incorporated herein by reference (the "Premises"). The Premises
are improved with a one story building containing approximately 36,960 rentable square feet of floor space (the "Building"). The foregoing statement regarding size is an approximation which the
parties agree is reasonable and the rental based thereon is not subject to revision in the event that the actual size differs from the approximation. The portion of the Premises not covered by the
Building is hereafter called the "Common Area." 

        1.2.    Condition.    In the event that within ninety (90) days following Landlord's delivery of possession of
the Premises, it is determined that any of the mechanical or utility systems serving the Premises existing upon such delivery of possession were not in good working condition as of such delivery of
possession (without regard to Tenant's subsequent misuse thereof or Tenant's subsequent alterations, additions or improvements to the Premises), then Landlord shall promptly take such action as is
required to cause
such mechanical and utility systems to be in good working condition. In the event that within one (1) year following Landlord's delivery of possession of the Premises, it is determined that
roof of the Building was in need of maintenance and repair as of the date of delivery of possession, then Landlord shall promptly take such action as is required to cause the roof to be in good
working condition. Landlord shall provide Tenant with copies of any and all closure plans and reports issued by the Fire Department of the City of Palo Alto or any other governmental or
quasi-governmental authority relating to the use by prior tenant of the Premises upon receipt of the same from the prior tenant of the Premises and the June 10, 2005 closure letter issued to
Clonetech. Subject to the foregoing provisions regarding the condition of the Premises as of the delivery of possession, Tenant hereby acknowledges: (i) that it is familiar with and has had the
opportunity to investigate the condition of the Premises (including but not limited to the mechanical, electrical and fire sprinkler systems, security, environmental aspects, compliance with
"Applicable Law", as defined in paragraph 5.2), the present and future suitability of the Premises for Tenant's intended use, (ii) that Tenant has made such investigation as it deems
necessary with reference to such matters and assumes all responsibility therefor, and without in any manner derogating from Tenant's obligations set forth herein including, without limitation, those
relating to maintenance and repair, Tenant accepts the Premises, including all fixtures, furnishings and equipment, in its present condition, state of repair and operating order and in its present "AS
IS" condition (other than as provided above), and (iii) that neither Landlord, nor any of Landlord's agents, has made any oral or written representations or warranties with respect to said
matters. 

        1.3.    Tenant Improvements.    Tenant shall construct all of its initial tenant improvements (the "Initial Tenant
Improvements") in accordance with the work letter attached as Exhibit B (the "Work Letter"). Landlord shall provide Tenant with a Three Hundred
Sixty Nine Thousand Six Hundred Dollars ($369,600) tenant improvement allowance on the terms set forth in the Work Letter. 

2

 

        2.    Term and Delivery of Possession.    

        2.1.    Term.    The term of this Lease shall be for a period of approximately one hundred twenty (120) months,
commencing on the "Commencement Date" (as defined in paragraph 2.2 below) and terminating on March 31, 2018 (the "Termination Date"). 

        2.2.    Delivery of Possession; Commencement Date.    Landlord shall deliver possession of the Premises to Tenant on
April 1, 2008. If for any reason Landlord cannot deliver possession of the Premises to Tenant by April 1, 2008, Landlord shall not be subject to any liability therefor, nor shall such
failure affect the validity of this Lease, or the obligations of Tenant hereunder, or extend the term hereof, but in such case, Tenant shall not, except as otherwise provided herein, be obligated to
pay rent or perform any other obligation of Tenant under the terms of this Lease until Landlord delivers possession of the Premises to Tenant. Notwithstanding anything to the contrary contained
herein, if Landlord has not
delivered the Premises to Tenant on or before July 1, 2008, Tenant shall have the right thereafter to terminate this Lease, and upon such termination, Landlord shall return all sums theretofore
deposited by Tenant with Landlord, and neither party shall have any further liability to the other. The date that Landlord delivers possession of the Premises to Tenant is sometimes referred to herein
as the "Commencement Date"; provided, however, that if Landlord delivers possession of the Premises to Tenant prior to April 1, 2008 pursuant to paragraph 2.3 below, the "Commencement
Date" shall be April 1, 2008. 

        2.3.    Early Entry.    The parties acknowledge that the tenancy of the existing tenant of the Premises expires as of
March 31, 2008. In the event that the existing tenant vacates the Premises early, Landlord shall deliver possession of the Premises to Tenant for the purpose of constructing its tenant
improvements and otherwise preparing the Premises for its intended use. Tenant's possession and use of the Premises prior to April 1, 2008 shall be subject to all of the terms and provisions
hereof, except for the obligation to pay Base Rent and Additional Rent(other than utilities), which obligation shall commence on the Commencement Date; provided, however, that Tenant shall pay any
utility costs arising as a result of or in connection with Tenant's possession of the Premises prior to the Commencement Date. 

        3.    Rent.    

        3.1.    Base Rent.    Tenant shall pay to Landlord during the term of this Lease monthly base rent (the "Base Rent"),
in installments and in the manner provided in paragraph 3.3 below as follows: 

 

 

					
	Month

 
	 	Base Rent Per Month 	 
	 Months 1 - 2
	 	$	0.00	 
	 Months 3 - 12
	 	$	105,336.00	 
	 Months 13 - 24
	 	$	108,759.42	 
	 Months 25 - 36
	 	$	112,294.10	 
	 Months 37 - 48
	 	$	115,943.66	 
	 Months 49 - 60
	 	$	119,711.83	 
	 Months 61 - 72
	 	$	123,602.46	 
	 Months 73 - 84
	 	$	127,619.54	 
	 Months 85 - 96
	 	$	131,767.18	 
	 Months 97 - 108
	 	$	136,049.61	 
	 Months 108 - Termination Date
	 	$	140,471.22	 

 

 
        3.2.    Additional Rent.    

        (a)   For
purposes of this Lease, "Operating Expenses" shall mean all costs of owning, managing, operating, maintaining, repairing, replacing and restoring the Premises,
including all costs, expenditures, fees and charges for the following: (i) supplying, operating, managing, 

3

 

maintaining,
repairing, replacing and restoring utilities, services and related Building systems (including HVAC), sewers, storm drains, pest control, mandatory recycling programs and trash removal
(to the extent not paid directly by Tenant pursuant to this Lease, and provided, that the cost of capital repairs and improvements shall be amortized as provided in (vii) below); provided,
however, that nothing contained in this subpart (i) shall be construed to make Landlord responsible for maintaining, repairing and/or replacing elements of the Premises that are not part of
Landlord's obligations under paragraph 7.2 of this Lease; (ii) maintaining, repairing, restoring and replacing the Common Area (including landscaped areas, sidewalks, walkways,
driveways, and the parking areas, including resurfacing, repainting, restriping and cleaning the same), the Building's exterior walls, and the roof of the Building, including the roof membrane
(provided, however, that the cost of capital replacements and improvements shall be amortized as provided in (vii) below); (iii) compensation (including salaries, wages, employment taxes,
fringe benefits and other payroll expenses of employees) for persons who perform duties in connection with the operation, management, maintenance, repair and improvement of the Premises, such
compensation to be appropriately allocated for persons who also perform duties unrelated to the Premises; (iv) premiums for property (including coverage for earthquake and flood if carried by
Landlord, to the extent permitted in paragraph 12.3 below), liability, rental income and other insurance relating to the Premises, and expenditures for deductible amounts paid under such
insurance (other than deductible amounts in excess of $100,000 for any earthquake coverage); (v) licenses, permits, certificates and inspections; (vi) complying with the requirements of
any Applicable Laws (with any capital improvements amortized as provided in (vii) below); (vii) amortization of capital improvements to or replacements of the Building or Premises, with
interest on the unamortized balance at the rate paid by Landlord on funds borrowed to finance such capital improvements or replacements (or, if Landlord finances such improvements out of Landlord's
funds without borrowing, the rate that Landlord would have paid to borrow such funds, as reasonably determined by Landlord), over the useful life of such improvements or replacements, as reasonably
determined by Landlord; provided, however, that Landlord shall not be required to amortize the cost if (A) if the total amount of such amortization for a particular capital improvement or
replacement is less than $20,000, Landlord shall be entitled to accelerate the amortization of the capital improvements and/or replacements in question and include in Operating Expenses the total cost
of such capital improvement or replacement, or (B) the capital improvements are required as a result of the specific and unique use of the Premises by Tenant (as compared with uses by tenants
in general), a change in use or alterations or modifications to the Premises by Tenant; (viii) property management fees in an amount equal to two percent (2.0%) of the annual Base Rent payable
by Tenant; (ix) [intentionally deleted]; (x) accounting, legal and other professional services incurred in connection with the operation of the Premises and the
calculation of Operating Expenses and Real Property Taxes; (xi) contesting the validity or applicability of any Applicable Laws or Real Property Taxes that may affect the Premises, to the
extent such action results in a decrease in Real Property Taxes; (xii) supplies, materials, tools and rental equipment; (xiii) [intentionally deleted];
(xiv) the cost of Real Property Taxes; and (xv) any other cost, expenditure, fee or charge, whether or not hereinbefore described, but without duplication, which in accordance with
generally accepted accounting principles would be considered an operating expense of managing, operating, maintaining or repairing the Premises. 

        (b)   Notwithstanding
paragraph 3.2(a), "Operating Expenses" shall not include (i) ground rent payments; (ii) interest and principal payments, loan fees
and other carrying costs on loans, capital leases or indebtedness of Landlord, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured; (iii) depreciation;
(iv) costs, fines or penalties incurred due to the violation of any Law by Landlord and/or its employees, agents or contractors or due to Landlord's gross negligence or willful misconduct;
(v) salaries, wages, 

4

 

benefits
and other compensation paid to officers or employees of Landlord above the grade of building manager or who are not assigned in whole or in part to the operation, management, maintenance or
repair of the Premises; (vi) general organizational, administrative and overhead costs relating to maintaining Landlord's existence, either as a corporation, partnership or other entity,
including general corporate, legal and accounting expenses incurred in connection therewith; (vii) costs and expenses, including legal fees, incurred in connection with negotiations or disputes
with employees, consultants, management agents, leasing agents, service providers, purchasers or mortgagees of the Building or the Premises; (viii) tax penalties, fines or interest incurred as
a result of Landlord's failure, inability or unwillingness to pay and/or to file any tax or informational returns when due, or from Landlord's failure to make any tax payment required to be made by
Landlord before delinquency (other than to the extent any such failure to pay and/or to file, or to pay before delinquency, is due to Tenant's failure to timely pay Additional Rent);
(ix) overhead and profit increment paid to the Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the Building or the Premises to the extent the same
exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; (x) costs arising from Landlord's charitable or political contributions;
(xi) costs incurred in connection with a proposed sale or refinancing of the Building or the Premises; (xii) income taxes measured by the net income of Landlord or the owner of any
interest in the Building or the Premises, franchise, capital stock, gift, estate or inheritance taxes or any federal, state or local documentary transfer taxes imposed in connection with recording a
deed transferring an interest in the Premises or any portion thereof or interest therein; (xiii) any expense to the extent covered and actually paid by insurance; (xiv) advertising and
promotional expenditures; (xv) the cost of containing, removing, or otherwise remediating any contamination of the Premises (including the underlying land and ground water) by any toxic or
hazardous materials (including, without limitation, asbestos and "PCB's") where Tenant is not responsible for such contamination under the terms of this Lease; and (xvi) costs for sculpture,
paintings, or other objects of art (and insurance thereon or extraordinary security in connection therewith). 

        (c)   Tenant
shall pay to Landlord an amount equal to the cost of all of the Operating Expenses as additional rent (the "Additional Rent") as follows: An amount shall be
estimated by Landlord prior to the beginning of each calendar year during the term hereof of the annual Operating Expenses during each calendar year of the term of the Lease and the same shall be
payable monthly, in advance, on the same day as the Base Rent is due hereunder. Landlord shall have the right to adjust its estimate of such expenses from time to time upon written notice to Tenant,
based upon reasonably anticipated changes in the amount of such expenses. Within one hundred twenty (120) days following the end of such calendar year, Landlord shall deliver to Tenant a
statement of actual Operating Expenses for such year; provided, however, that Landlord's failure to timely deliver such statement shall not prevent Landlord from thereafter collecting Additional Rent
with respect to such Operating Expenses. If Tenant has overpaid Operating Expenses, at Landlord's option either Landlord shall pay to Tenant or Tenant shall be entitled to a credit against the payment
for Rent next coming due under this Lease in the amount of such excess (except that any such overpayment allocable to the final year of the term of the Lease shall be refunded to Tenant following the
satisfaction of all Tenant obligations under this Lease), and if Tenant has underpaid the Operating Expenses, Tenant shall pay any such deficiency to Landlord within thirty (30) days following
receipt of such statement. Landlord's obligation to make such refund and Tenant's obligation to pay such deficiency, as applicable, shall survive the expiration of the term or earlier termination of
this Lease. Any failure of Landlord to deliver the statement of Operating Expenses as provided herein shall not relieve either party of their respective obligations under this paragraph. The
obligations of Tenant to pay any Additional Rent attributable to periods during the term of 

5

 

the
Lease and not previously paid by Tenant shall survive the expiration or earlier termination of this Lease. 

        (d)   Tenant
and its duly authorized representatives shall have the right to audit and copy the records of Landlord related to Operating Expenses with respect to any calendar
year within one hundred twenty (120) days following receipt of the applicable statement of actual Operating Expenses for such calendar year, upon not less than thirty (30) days' prior
written notice to Landlord, during normal business hours at the business offices of Landlord's property manager for the Premises; provided that (1) Tenant shall not conduct more than one
(1) such audit in any calendar year, (2) Tenant shall keep such information in strict confidence and shall use commercially reasonable efforts to cause any other person or entity
performing such audit or inspection to keep such information in strict confidence, and (3) Tenant shall supply Landlord with a copy of the final audit report within twenty (20) days
following Tenant's receipt of the same. In the event Tenant in good faith disputes the accuracy of any statement of actual Operating Expenses on the basis of any such audit, such dispute must be
alleged in reasonable detail in written notice to Landlord within thirty (30) days following the delivery to Landlord of Tenant's audit report. If Tenant's payments of Operating Expenses are
determined by Landlord and Tenant to have been overstated or understated for any calendar year, the parties shall within thirty (30) days after determination of such overstatement or
understatement make such adjustment payment or refund as is applicable. Tenant shall pay in a timely manner as required by this Lease any amounts stated as due on each statement of actual Operating
Expenses delivered by Landlord, provided that such payment shall not waive any right to audit and/or dispute by Tenant as set forth herein. Landlord shall retain its books and records relating to each
year's Operating Expenses for a period of at least the period during which an audit thereof hereunder may be conducted. Unless Tenant raises any objections to a statement of Operating Expenses within
the periods specified therefore hereunder, such statement shall conclusively be deemed correct absent manifest error and Tenant shall have no right thereafter to dispute such Statement or any item
therein or the computation of Additional Rent based thereon. 

        3.3.    Manner of Payment.    All amounts payable or reimbursable by Tenant under this Lease, including late charges
and interest, shall constitute rent and shall be payable and recoverable as rent in the manner provided in this Lease. Except as otherwise expressly provided herein, Tenant shall pay to Landlord the
rent, including the Base Rent and Additional Rent calculated as set forth above, without deduction, offset or abatement, and without prior notice or demand, in advance commencing on the Commencement
Date and thereafter on the first day of each calendar month of the term of this Lease. Any sums payable to Landlord on Landlord's demand under the terms of this Lease, as opposed to regularly
scheduled payments of Base Rent and Additional Rent, shall be due and payable within fifteen (15) days after written notice from Landlord of the amount due. Rent shall be payable in lawful
money of the United States to Landlord at the address of Landlord set forth in paragraph 23 below or to such other persons or at such other places as Landlord may from time to time designate in
writing. Tenant's obligation to pay rent for any partial month shall be prorated on the basis of a thirty (30) day month. 

        3.4.    Late Payment Charge.    Tenant hereby acknowledges that late payment by Tenant to Landlord of rent and other
sums due hereunder will cause Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult to ascertain. Such costs include, but are not limited to,
processing and accounting charges, and late charges which may be imposed upon Landlord by the terms of any ground lease, mortgage or trust deed covering the Premises. Accordingly, if any installment
of rent or any other sum due from Tenant shall not be received by Landlord or Landlord's designee within five (5) days after notice that such amount is delinquent with respect to the first late
payment in any calendar year and thereafter within five (5) days after such amount shall be due, then, Tenant shall pay to Landlord a late 

6

 

charge
equal to five percent (5%) of such overdue amount, plus interest at the annual rate of ten percent (10%) commencing as of the date that the payment was due. The parties hereby agree that such
late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. Acceptance of such late charge by Landlord in and of itself shall in no
event constitute a waiver of Tenant's Default or Breach with respect to such overdue amount, nor prevent Landlord from exercising any of the other rights and remedies granted hereunder. 

        3.5.    Security Deposit.    

        (a)   Upon
execution of this Lease, Tenant shall deposit with Landlord in cash the sum of One Hundred Forty Thousand Four Hundred Seventy One Dollars and 18/100 ($140,471.18)
(the "Deposit") as security for the faithful performance by Tenant of all of its obligations hereunder. If Tenant fails to pay Base Rent or any other sums due hereunder, or otherwise commits a breach
with respect to any non-monetary obligation of Tenant under this Lease, Landlord may use, apply, or retain all or any portion of the Deposit for the payment of any rent or other sum in
default, or to reimburse or compensate Landlord for any expenditure, loss or damage (including attorneys' fees) which Landlord may suffer or incur by reason thereof. If Landlord so uses or applies all
or any portion of the Deposit, Tenant shall, within fifteen (15) days after written demand therefor, deposit with Landlord an amount in
cash sufficient to restore the Deposit to the full amount required by this Lease. Landlord shall not be required to keep the Deposit separate from its general funds. If Landlord disposes of its
interest in the Premises, Landlord may deliver or credit the Deposit to Landlord's successor-in-interest, and Landlord thereupon shall be relieved of further responsibility
with respect to the Deposit. If Tenant performs all of Tenant's obligations hereunder, Landlord shall, at the expiration or earlier termination of the term of this Lease and after Tenant has vacated
the Premises, return to Tenant (or, at Landlord's option, to the last assignee, if any, of Tenant's interest herein), that portion of the security deposit not used or applied by Landlord in accordance
with the terms of this Lease. No part of the security deposit shall be considered to be held in trust, to bear interest or other increment for its use, or to be prepayment for any moneys to be paid by
Tenant under this Lease. Tenant hereby waives California Civil Code Section 1950.7 and all other provisions of law now in force or that become in force after the date of execution of this
Lease, that provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in the payment of rent, to repair damage caused by Tenant, or to clean the
Premises. Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any loss or damage caused by the act or omission of Tenant in violation of the terms of this
Lease. Tenant may not assign (except in connection with an assignment of this Lease permitted pursuant to paragraph 15) or encumber the Deposit, and any attempt to do so shall be void and, in
all events, not binding upon Landlord. 

        (b)   Alternatively,
Tenant may, in lieu of a cash security deposit, deliver to Landlord a negotiable standby letter of credit (the "Letter of Credit") in form acceptable to
Landlord in Landlord's discretion in the amount of the Deposit. The Letter of Credit shall be held by Landlord as security to secure Tenant's faithful performance of Tenant's obligations under this
Lease. The Letter of Credit shall be issued by a financial institution reasonably acceptable to Landlord (the "Bank"). Landlord shall have the right to draw down an amount up to the face amount of the
Letter of Credit if any of the following shall have occurred or be applicable: (1) such amount is due to Landlord under the terms and conditions of this Lease, (2) Tenant has filed a
voluntary petition under the U. S. Bankruptcy Code or any state bankruptcy code (collectively, "Bankruptcy Code"), (3) an involuntary petition has been filed against Tenant under the
Bankruptcy Code, or (4) the Bank has notified Landlord that the Letter of Credit will not be renewed. If Tenant fails to pay Rent or otherwise defaults with respect to any 

7

 

provision
of this Lease and fails to cure any such default within any applicable notice and cure period provided in this Lease, Landlord may draw on the Letter of Credit for the payment of any rent or
other sum in default, or to reimburse or compensate Landlord for any expenditure, loss or damage (including attorneys' fees) which Landlord may suffer or incur by reason thereof. The Letter of Credit
shall contain language allowing Landlord to draw upon the Letter of Credit upon presentation to the issuer of the Letter of Credit of Landlord's written statement that Landlord is entitled to the
funds represented by such Letter of Credit in accordance with the terms hereof. If Landlord so uses or applies all or any portion of the amount represented by the Letter of Credit, then Tenant shall,
within ten (10) days after written demand therefor, deliver a replacement letter of credit in the amount drawn so that the total amounts represented by the Letter of Credit and the replacement
letter of credit equals $140,471.18 and Tenant's failure to do so shall be a material breach of this Lease. The Letter of Credit shall (a) be "callable" at sight, irrevocable and unconditional,
(b) be fully assignable by Landlord, its successors and assigns and (c) permit partial draws and multiple presentations and drawings, (d) have an expiration date that is sixty
(60) days after the Termination Date; (e) be nonrenewable by the Bank only after not less than sixty (60) days prior written notice from the Bank to Landlord of such nonrenewal,
and (e) be otherwise subject to the Uniform Customs and Practices for Documentary Credits (1993 Revision) International Chamber of Commerce Publication #500. Tenant shall pay all
expenses, points and/or fees incurred by Tenant in obtaining, renewing and extending the Letter of Credit. No later than thirty (30) days prior to the nonrenewal of the Letter of Credit or any
replacement thereof, Tenant shall deliver a new Letter of Credit meeting the requirements of this paragraph 3.5(b). If Tenant fails to deliver a new Letter of Credit as required herein, then
Landlord shall have the right, at its sole option, to draw upon and present the then existing Letter of Credit for the entire amount available thereunder. Until such time as Tenant shall thereafter
deliver a new Letter of Credit in the form and substance required hereunder, Landlord shall retain possession of the funds so drawn as a security deposit to secure Tenant's faithful obligations under
this Lease. Any such replacement Letter of Credit shall satisfy and be subject to the provisions this paragraph 3.5(b) Should the Letter of Credit then in effect be revoked, then Tenant shall
deliver a replacement Letter of Credit in the form and substance required hereunder. The unused portion of the Letter of Credit shall be returned to Tenant within forty five (45) days following
the expiration, without renewal, of the term of this Lease and after Tenant has vacated the Premises; provided, however, that if prior thereto a voluntary petition is filed by Tenant, or an
involuntary petition is filed against Tenant by any of Tenant's creditors, under the Bankruptcy Code, then Landlord shall not be obligated to make such payment in the amount of the unused Letter of
Credit proceeds until either all preference issues relating to payments under this Lease have been resolved in such bankruptcy or reorganization case or such bankruptcy or reorganization case has been
dismissed. The Letter of Credit will be honored by the Bank regardless of whether Tenant disputes Landlord's right to draw upon the Letter of Credit. The Letter of Credit shall also provide that
Landlord, and its successors and assigns, may, at any time and without notice to Tenant and without first obtaining Tenant's consent thereto, transfer (one or more times) all or any portion of its
interest in and to the Letter of Credit to another party, person or entity. In the event of a transfer of Landlord's interest in the Premises, Landlord shall transfer the Letter of Credit, in whole or
in part, to the transferee and thereupon Landlord shall, without any further agreement between the parties, be released by Tenant from all liability therefor, and it is agreed that the provisions
hereof shall apply to every transfer or assignment of the whole or any portion of said Letter of Credit to a new landlord. In connection with any such transfer of the Letter of Credit by Landlord,
(i) Tenant shall, at Tenant's sole cost and expense, execute and submit to the Bank such applications, documents and instruments as may be necessary to effectuate such transfer, (ii)Tenant
shall be responsible for paying the Bank's transfer and 

8

 

processing
fees in connection therewith; and (iii) if requested by the issuer, Landlord shall deliver the Letter of Credit to the issuer for transfer. The use, application or retention of the
Letter of Credit, or any portion thereof, by Landlord shall not prevent Landlord from exercising any other right or remedy provided by this Lease or by any applicable law, it being intended that
Landlord shall not first be required to proceed against the Letter of Credit, and shall not operate as a limitation on any recovery to which Landlord may otherwise be entitled. 

        4.    Taxes.    

        4.1.    Tenant's Personal Property.    Tenant shall pay directly to the charging authority as provided in
paragraph 3.2 all taxes assessed against and levied upon Tenant's leasehold improvements, trade fixtures, furnishings, equipment and all other personal property and merchandise of Tenant
situated in or about the Premises. 

        4.2.    Real Property Taxes.    

        (a)   Tenant
shall pay to Landlord at least ten (10) days prior to delinquency all Real Property Taxes (as hereinafter defined) levied with respect to the Premises. 

        (b)   The
term "Real Property Taxes" as used herein shall mean (i) all taxes, assessments, levies and other charges of any kind or nature whatsoever, general and
special, foreseen and unforeseen (including all installments of principal and interest required to pay for any general or special assessments for public improvements, services or benefits and any
increases resulting from reassessments caused by any new construction or change in valuation), now or hereafter imposed by any governmental or quasi-governmental authority or special district having
the direct or indirect power to tax or levy assessments, which are levied or assessed against or with respect to or by reason of (a) the ownership, value, possession or use of the Premises (as
now constructed or as may at any time hereafter be constructed, altered or otherwise changed) including, without limitation, governmental charges, fees or assessments for transit or traffic mitigation
(including area-wide traffic improvement assessments and transportation system management fees), housing, police, fire or other governmental service or purported benefits to the Premises,
including assessments, taxes, fees, levies and charges imposed by governmental agencies for such purposes as street, sidewalk, road, utility construction and maintenance, refuse removal and for other
governmental services, (b) the fixtures, equipment and other real or personal property of Landlord that are an integral part of the Premises or used in operation of the Premises, or
(c) the use of the Common Area, public utilities, or energy within the Premises; (ii) all charges, levies or fees imposed by reason of environmental regulation or other governmental
control of the Premises unless the same are imposed as a result of environmental contamination on or under the Premises for which Tenant is not responsible under paragraph 6 below;
(iii) any new excise, transaction, sales, privilege, or other tax now or hereafter imposed upon Landlord as a result of this Lease; and (iv) the reasonable cost of contesting by
appropriate proceedings the amount or validity of any taxes, assessments or charges described above. 

        If
at any time during the lease term the taxation or assessment of the Premises prevailing as of the Commencement Date shall be altered so that in lieu of or in addition to any Real
Property Taxes described above there shall be levied, assessed or imposed (whether by reason of a change in the method of taxation or assessment, creation of a new tax or charge or any other cause) an
alternate, substitute or additional tax or charge (i) on the value, use or occupancy of the Premises, (ii) on or measured by the gross receipts, income or rentals from the Premises, or
on Landlord's business of leasing the Premises, or (iii) computed in any manner with respect to the operation of the Premises, then any such tax or charge, however designated, shall be included
within the meaning of the term "Real Property Taxes" for purposes of this Lease. 

9

 

        Notwithstanding
the foregoing, the term "Real Property Taxes" shall not include estate, inheritance, transfer, gift or franchise taxes of Landlord or the federal or state income tax
imposed on Landlord's income from all sources. 

        (c)   Tenant's
liability to pay Real Property Taxes shall be prorated on the basis of a 365-day year to account for any fractional portion of a fiscal tax year
included in the lease term at the commencement or expiration of the term. 

        (d)   Tenant,
at its cost, shall have the right at any time to seek a reduction in or otherwise contest any Real Property Taxes, by action or proceeding against the entity
with authority to assess or impose the same. Landlord shall not be required to join in any proceeding or action brought by Tenant unless the provisions of applicable regulations require that such
proceeding or action be brought by or in the name of Landlord, in which event Landlord shall join in such proceeding or action or permit it to be brought in Landlord's name, provided that Tenant
protect, indemnify, and hold Landlord free and harmless from and against any liability, cost or expense in connection with or as a result of such proceeding or contest. Landlord shall continue, during
the pendency of such proceeding or action, to pay the Real Property Taxes due in accordance with this paragraph 4. If Tenant is successful in such action or proceeding, Tenant shall be entitled
to receive any refund resulting from such action or proceeding to the extent Tenant paid the Real Property Taxes refunded. 

        5.    Use.    

        5.1.    Permitted Uses.    The Premises shall be used and occupied only for the following purposes: laboratory
research and development and general offices, assembly, manufacturing, and other lawful purposes incidental thereto which are permitted by applicable zoning ordinances, and for no other use or purpose
without Landlord's prior written consent. 

        5.2.    Compliance with Law.    Tenant shall not use the Premises or suffer or permit anything to be done in or about
the Premises which will violate any law, statute, zoning restriction, ordinance or governmental law, rule, regulation, permit or requirement of duly constituted public authorities, covenants,
easements and restrictions of record, permits or the requirements of any applicable fire insurance underwriting or rating bureau now or hereafter constituted relating to the condition, use or
occupancy of the Premises as may now or hereafter be in effect, including, without limitation, (i) the law commonly known as "The Americans With Disabilities Act" ("ADA"), (ii) subject
to paragraph 5.4 below, laws pertaining to Hazardous Substances, industrial hygiene and environmental conditions on, in, under or about the Premises (including soil and groundwater conditions),
including, but not limited to, the laws referenced in paragraph 5.4(a) below; and (iii) subject to paragraph 5.4 below, laws pertaining to the use, generation, manufacture,
production, installation, maintenance, removal, transportation, storage, spill or release of any Hazardous Substances as hereinafter defined (individually, an "Applicable Law" and collectively, the
"Applicable Laws"). Tenant, at Tenant's sole expense, shall promptly comply with all Applicable Laws including, without limitation, improvements undertaken by Tenant to the Premises or future
Applicable Laws. Tenant shall, within five (5) business days after receipt of Landlord's written request, provide Landlord with copies of all documents and information, including, but not
limited to, permits, registrations, applications, reports and certificates, evidencing Tenant's compliance with any Applicable
Law specified by Landlord to the extent that the same is available from governmental agencies to evidence such compliance. Tenant shall promptly upon receipt or knowledge thereof, notify Landlord in
writing (with copies of any documents involved) of any claim, notice, citation, warning, complaint or report asserting the failure of the Premises or Tenant's use thereof to comply with any Applicable
Law. 

10

 

 

        5.3.    Restrictions on Use.    Tenant shall not use or permit the use of the Premises in any manner that will create
waste on the Premises or constitute a nuisance to, or disturb the quiet enjoyment of, any occupant or user of any adjoining building. Tenant shall not do, bring, keep or sell anything in or about the
Premises that is prohibited by, or that will cause a cancellation of, any insurance policy covering the Premises or any part thereof. Tenant shall not use any apparatus, machinery or other equipment
in or about the Premises that may cause damaging noise or vibration or overload existing electrical systems, or otherwise place any loads upon the floors, walls or ceilings of the Premises in excess
of their capacity or jeopardize the structural integrity of the Building or any part thereof. Tenant shall not make any penetrations of the roof or exterior of the Building without the prior written
approval of Landlord (with Tenant acknowledging that in connection with any such approval Landlord will require that the roof penetrations must be treated in a certain manner with materials and by a
contractor all approved by Landlord). No materials or articles of any nature shall be stored upon any portion of the Common Area unless located within an enclosure approved by Landlord. Tenant shall
not cause or permit any toxic wastes or by-products or other harmful chemicals to be discharged into the plumbing or sewage system of the Building or onto the land underlying or adjacent
to the Building unless such discharge is permitted by governmental authorities (to the extent such permission is required) and allowed under Applicable Laws. 

        5.4.    Hazardous Substances.    

        (a)    Definitions.    The term "Hazardous Substance" as used in this Lease shall mean any product, substance,
chemical, material or waste whose presence, nature, quantity and/or intensity of existence, use, manufacture, disposal, transportation, spill, release or effect, either by itself or in combination
with other materials is or may be either: (i) injurious or hazardous to the public health, safety or welfare, the environment or the Premises, (ii) now or in the future regulated or
monitored by any governmental authority, or (iii) a basis for liability of Landlord to any governmental agency or third party under any applicable statute or common law theory. Hazardous
Substance shall include, but not be limited to, any product, substance, chemical, material or waste that (i) now or in the future is defined as a hazardous waste, hazardous substance, hazardous
material, pollutant or contaminant under any Applicable Laws, including the Comprehensive Environmental Response Compensation and Liability Act, 42 U.S.C. § 9601 et seq., the
Resource Conservation and Recovery Act, 42 U.S.C. § 6901 et seq., and Sections 25117 and 25316 of the California Health and Safety Code, or
(ii) is toxic, explosive, corrosive, flammable, radioactive, carcinogenic, dangerous or otherwise hazardous, including gasoline, diesel fuel, petroleum hydrocarbons, polychlorinated biphenyls
(PCBs), asbestos, radon, methane, lead, microbial matter (including mold), urea and formaldehyde foam insulation. The term "Reportable Use" as used in this Lease shall mean: (i) the
installation or use of any above or below ground storage tank, and (ii) the generation, possession, storage, use, transportation or disposal of a Hazardous Substance that requires a permit
from, or with respect to which a report, notice, registration or business plan is required to be filed with, any governmental authority. Reportable Use shall also include any Hazardous Substance
brought on the Premises by Tenant or any person under Tenant's control for which a notice must be given to persons entering or occupying the Premises or neighboring properties. 

        (b)    Use Requires Consent.    Tenant shall not cause or permit any Hazardous Substance to be brought upon, kept,
used, discharged, released or disposed of in or about the Premises by Tenant, its agents, employees, contractors or invitees, without the prior written consent of Landlord. Notwithstanding the
foregoing, Tenant shall be permitted to use reasonable quantities and the types of Hazardous Substances on the Premises which are typical and customary in the normal course of Tenant's business
permitted on the Premises, provided 

11

 

that:(i) Tenant
shall comply with all Applicable Laws in connection with such usage; (ii) Tenant shall dispose of all such Hazardous Substances in the manner required by Applicable Laws
and good practices; and (iii) Tenant shall not engage in any activity in, on or about the Premises which constitutes a Reportable Use of Hazardous Substances without the express prior written
consent of Landlord and compliance with all Applicable Laws. Landlord hereby consents to the Reportable Use described on Exhibit D provided that such uses are subject to all the terms and
conditions of those permits and of this paragraph 5. Tenant shall give Landlord notice of any Reportable Use concurrently with Tenant's periodic submission to the local fire department or other
governmental authority to which Tenant must report such use. In addition, Landlord may (but without any obligation to do so) condition its consent to the use or presence of any Hazardous Substance,
activity or storage tank by Tenant upon Tenant's giving Landlord such additional assurances as Landlord, in its reasonable discretion, deems necessary to protect itself, the public, the premises and
the environment against damage, contamination or injury and/or liability therefrom or therefor, including, but not limited to, the installation (and removal on or before Lease expiration or earlier
termination) of reasonably necessary protective modifications to the premises and/or the deposit of an additional Deposit under paragraph 3.5. 

        (c)    Landlord's Rights.    Subject to the provisions of paragraph 19, Landlord shall have the right, but not
the obligation, to enter the Premises and conduct an inspection thereof, including invasive tests, at any reasonable time (i) to confirm Tenant's compliance with the provisions of this
paragraph 5.4, including but not limited to the compliance of the Premises and the activities thereon with Applicable Laws, and (ii) to perform Tenant's obligations under this
paragraph 5.4 if Tenant has failed to do so after reasonable notice to Tenant. Landlord shall also have the right to engage qualified Hazardous Substances consultants to inspect the Premises
and review Tenant's compliance with the provisions of this paragraph 5.4, including review of all permits, reports, plans, and other documents regarding the same. If such inspection shows that
Tenant has breached its obligations herein regarding Hazardous Substances, Tenant shall pay to Landlord on demand the costs of Landlord's consultants' fees and all costs reasonably incurred by
Landlord in performing Tenant's obligations under this paragraph 5.4.
Landlord shall use reasonable efforts to minimize any interference with Tenant's business caused by Landlord's entry into the Premises. 

        (d)    Duty to Inform.    If Tenant has knowledge or has reasonable cause to believe that a Hazardous Substance, or a
condition involving or resulting from same, has come to be located in, on, under or about the Premises, other than as previously consented to by Landlord or as permitted hereunder, Tenant shall
promptly give written notice of such fact to Landlord. Tenant shall also promptly give Landlord notice (and a copy, if applicable) of any statement, report, notice, registration, application, permit,
business plan, license, claim, action, investigation or proceeding received by Tenant from, any governmental authority or private party, or otherwise known to Tenant, concerning the unlawful presence,
spill, release, discharge of, or exposure to, any Hazardous Substance in, on, or about the Premises, including but not limited to all such documents as may relate to any Reportable Uses on the
Premises by Tenant. As of the Commencement Date, Tenant shall provide Landlord with a complete list of all Hazardous Substances to be stored, handled, used and/or disposed of at the Premises
(including, without limitation, as to common trade name, chemical name, components and concentration and maximum quantity expected to be stored), excluding standard janitorial and office products.
Tenant shall update this list at reasonable intervals throughout the term of the Lease so it remains current. Within fifteen (15) days following Tenant's receipt of Landlord's request therefor
from time to time during the term of the Lease, Tenant shall deliver to Landlord a summary of such Hazardous Substances as are actually then being stored, handled, used and/or disposed of at the
Premises (including, without limitation, as to common trade 

12

 

name,
chemical name, components and concentration and maximum quantity stored) in such form as may be reasonably requested by Landlord. 

        (e)    Compliance.    Tenant shall procure, maintain in effect and comply with all conditions of all permits, licenses
and other governmental and regulatory approvals required for the use, storage or disposal of Hazardous Materials at the Premises for which Tenant is responsible under this Lease. Tenant shall handle,
treat, deal with and manage in all respects all Hazardous Substances at the Premises in complete conformity with all Applicable Laws and good industry practices regarding management of such Hazardous
Substances. Tenant shall at Tenant's expense promptly take all actions required by any governmental agency or entity in connection with or as a result of the presence of Hazardous Substances at the
Premises for which Tenant is responsible under this paragraph 5.4, including inspection, monitoring and testing, performing all cleanup, removal and remediation work required with respect to
those Hazardous Substances, complying with all closure requirements and post-closure monitoring, and filing all required reports or plans. All of the foregoing work shall be performed in a
good, safe and workmanlike manner by Tenant or its consultants and contractors qualified and licensed to undertake such work and in a manner that will not unreasonably interfere with Landlord's
operation, leasing and sale of the Premises. Tenant shall deliver to Landlord concurrently with delivery to any governmental agency, or promptly after receipt from any such agency, copies of all
permits, closure or remedial action plans; and all material and relevant notices, and all other documents or communications relating to Hazardous Materials at the Premises and/or compliance with
Applicable Laws regarding the same for which Tenant is responsible under this Lease. Specifically, and not by way of limitation, Tenant shall promptly submit to Landlord a copy of any regulatory
filing made to the Fire Department of the City of Palo Alto ("PAFD") or any other governmental or quasi-governmental agency with respect to Hazardous Substances and prior to the expiration or earlier
termination of this Lease, Tenant shall obtain an environmental closure authorization from the PAFD is accordance with a closure plan previously prepared by Tenant and any other applicable
requirements of the PAFD. 

        (f)    Indemnification by Tenant.    Tenant shall be responsible for and shall indemnify, protect, defend and hold
Landlord, its officers, directors, agents, employees, lenders and their respective successors and assigns, harmless from and against any and all damages, losses, liabilities, judgments, costs, claims,
liens, expenses, penalties, permits and reasonable attorney's and consultant's fees arising out of or involving Tenant's failure to comply with all Applicable Laws with respect to Hazardous Substances
and/or any Hazardous Substance or storage tank brought on the Premises by or for Tenant or under Tenant's control (hereinafter referred to as "Claims") at any time during Tenant's possession prior to
or during the term of this Lease, including, but not limited to, the effects of any contamination or injury to person, property or the environment, and the cost of investigation (including reasonable
consultant's and attorney's fees and testing), removal, remediation, restoration and/or abatement thereof, or of any contamination therein involved. All of Tenant's and its assignee's and sublessee's
agents, employees, contractors, invitees, and guests shall be deemed under Tenant's control; provided, however that a person who is on the Premises without the express or implied consent or permission
of Tenant or sublessees shall not be deemed under Tenant's control. Tenant's indemnity obligations shall include (without limitation), and Tenant shall reimburse Landlord for, the following:
(i) losses in or reductions to rental income resulting from Tenant's use, storage, disposal of or failure to timely remove Hazardous Substances; in violation of its obligations under this
Lease; (ii) all costs of refitting or other alternations to the Premises necessitated by Tenant's use, storage, disposal of or failure to timely remove Hazardous Substances including, without
limitation, alterations required to accommodate an alternate use of the Premises; (iii) any diminution in the fair market and/or rental value of the Premises or 

13

 

any
portion thereof caused by Tenant's use, storage, disposal of or failure to timely remove Hazardous Substances; and (iv) costs incurred by Landlord in performing Tenant's obligations under
this paragraph 5.4. Tenant agrees to defend all Claims on behalf of Landlord with counsel reasonably acceptable to Landlord, and to pay all fees, costs, damages, or expenses relating to or
arising out of any indemnifiable Claim including reasonable attorneys' fees and costs. Tenant shall further be responsible for and shall indemnify, defend, and hold Landlord and its agents harmless
from and against all Claims, including reasonable attorneys' fees and costs, arising out of or in connection with any removal, clean-up, or restoration work which is required by any
government agency having jurisdiction and which arises from Tenant's storage, use, or disposal of Hazardous Substances on the Premises at any time prior to or during the term of this Lease. No
termination, cancellation or release agreement entered into by Landlord and Tenant shall release Tenant from its obligations under this Lease with respect to Hazardous Substances or storage tanks,
unless specifically so agreed by Landlord in writing at the time of such agreement. 

        (g)    No Lien.    Tenant shall not suffer any lien to be recorded against the Premises as a consequence of any
Hazardous Substances for which Tenant is responsible under this paragraph 5.4, including any so-called state or federal "super fund" lien related to the remediation of any Hazardous
Substances. 

        (h)    Remediation; Surrender.    Tenant shall upon demand by Landlord, and at Tenant's sole cost and expense,
promptly take all actions to remediate the Premises from the effects of any Hazardous Substances for which Tenant is responsible under this paragraph 5.4. Such remediation shall include, but
not be limited to, the investigation of the environmental condition of the Premises, the preparation of any feasibility studies, reports or remedial Plans, and the performance of any clean up,
remediation, containment, monitoring or restoration work, whether on or off the Premises. Tenant shall take all actions necessary to remediate the Premises from the effects of such Hazardous
Substances to a condition allowing unrestricted use of the Premises, but in no event to a condition which is better than the condition existing as of the Commencement Date, notwithstanding any lesser
standard of remediation allowable under Applicable Laws. Tenant shall pay all costs in connection with such investigatory and remedial activities, including but not limited to all power and utility
costs, and any and all taxes or fees that my be applicable to such activities. Tenant shall promptly provide to Landlord copies of testing results and reports that are generated in connection with the
above activities and/or that are submitted to any governmental entity. Promptly upon completion of such investigation and remediation, Tenant shall permanently seal or cap all monitoring wells and
test holes in accordance with good engineering practices and compliance with Applicable Laws, remove all associated equipment, and restore the Premises to the condition as set forth above (but in no
event to a condition which is better than the condition existing as of the Commencement Date), which shall include without limitation, the repair of any surface damage, including paving, caused by
such investigation or remediation. Tenant shall surrender the Premises to Landlord, upon the expiration or earlier termination of the Lease, free of Tenant's Hazardous Substances for which Tenant is
responsible under this paragraph 5.4. 

        (i)    Survival.    The provisions of this paragraph 5.4 shall survive the expiration or earlier termination of
this Lease. 

        6.    Maintenance and Repairs.    

        6.1    Tenant's Obligations.    Except for items which are the responsibility of Landlord pursuant to
paragraph 6.2 below and the other express provisions of this Lease, Tenant shall, at Tenant's sole cost and expense and at all times, keep the Building and every part thereof and Tenant's signs
in good and safe order, condition and repair (and replace, if necessary), whether or not such 

14

 

portion
of the Building requiring repair, or the means of repairing the same, are reasonably or readily accessible to Tenant, and whether or not the need for such repairs occurs as a result of
Tenant's use, any prior use, the elements or the age of such portion of the Building, including, without limiting the generality of the foregoing, all equipment or facilities within or outside the
Building, such as the generator, plumbing, heating, air conditioning, ventilating, electrical, lighting facilities, boilers, fired or unfired pressure vessels, fire sprinkler and/or standpipe and hose
or other automatic fire extinguishing system, including fire alarm and/or smoke detection systems and equipment, fixtures, walls, ceilings, floors, windows, doors, located in, on or about the
Building. Tenant, in keeping the Building in good order, condition and repair, shall exercise and perform good maintenance practices. With respect to
such maintenance and repair, Tenant shall at its expense undertake and provide the following during the term of this Lease: 

          (i)  a
heating, ventilating and air conditioning ("HVAC") systems preventive maintenance contract covering all HVAC systems servicing the Building, which shall provide for
and include, without limitation, maintenance, repair and replacement of filters, condensers and other parts, oiling and lubricating of machinery, parts replacement, adjustment of drive belts, oil
changes, weather proofing of all exposed HVAC equipment and ducts, and other preventive maintenance. Tenant shall at its sole coat and expense: (A) have routine maintenance performed at least
every sixty (60) days by a company acceptable to Landlord and in a form acceptable to Landlord and require the company performing such maintenance to deliver Landlord with copies of the HVAC
maintenance reports, which reports shall be in form acceptable to Landlord, concurrently with providing the same to Tenant; (B) require that Landlord be delivered, at the same time that Tenant
receives the same, copies of all other reports obtained by Tenant with respect to the HVAC systems; and (C) promptly upon receipt, provide Landlord with copies of all maintenance and repair
invoices received by Tenant with respect to the HVAC systems and evidence that the same have been paid by Tenant; and (D) cause the HVAC systems to be maintained, repaired and replaced in a
first class manner; 

         (ii)  a
service contract for the washing of all exterior windows of the Building (both interior and exterior surfaces) which provides for the periodic (no less than two times
per year) washing of all such windows; and 

        (iii)  a
fire sprinkler system, water flow and smoke alarm preventative maintenance and testing contract covering all sprinkler and smoke alarm systems services in the
Building. All repairs required to be made shall be made promptly with new materials of like kind and quality. 

        The
parties acknowledge that Landlord has a particular interest in maintaining the HVAC system because of its value to Landlord's ownership of the Building. In addition to the other
rights and remedies available to it, Landlord may elect at any time to terminate Tenant's right to be responsible for the maintenance and repair of the HVAC systems if Tenant fails to comply with the
forgoing covenants, or, if in Landlord's reasonable judgment, Tenant has not repaired or maintained such in first class condition. If Landlord undertakes the maintenance or repair of the HVAC systems,
the cost to Landlord shall be included in Paragraph 3.2 (a) Operating Expenses. 

        Tenant
shall obtain Landlord's prior written consent to any work performed on or to the roof of the Building by or on behalf of Tenant. 

        Acknowledging
that Landlord is responsible for providing maintenance of the Common Area, Tenant shall use the parking and Common Area so that they are in a neat and clean condition and
in good appearance consistent with other buildings in the area. Tenant shall not store anything nor place any storage sheds or other structures in the Common Area. All trash shall be stored in closed
containers approved by the scavenger company and shall not overflow those containers. Tenant shall use the parking lot only for parking and ingress and egress of vehicles used by it, its 

15

 

employees
and invitees, and for no other purpose. No inoperable vehicles shall be left in the parking area. 

        6.2    Landlord's Obligations.    Subject to Tenant's obligations under paragraph 6.1, Landlord shall, at
Tenant's expense, payable as Operating Expenses in accordance with paragraph 3.2, keep in good condition, order and repair the Common Area and all elements therein, any plate glass and
skylights located on the exterior of the Building, the roof of the Building (membrane and structure) (except that Tenant shall repair at Tenant's expense, and with Landlord's approval as provided in
paragraph 5.3, any damage caused by Tenant's activities on or to the roof, including, but not limited to, the installation of air conditioning equipment and/or duct work, or other roof
penetrations, and improper flashing or caulking, and any damage to exposed air conditioning equipment and duct work installed by or for Tenant), and the structural slabs, columns and other structural
elements of the Building (including, without limitation, the painting or cleaning of the exterior walls of the Building). Tenant shall promptly notify Landlord of the need for Landlord to make any of
repairs of which it becomes aware. Notwithstanding anything to the contrary contained in this Lease, (i) Landlord shall not be liable to Tenant for failure to make repairs as herein
specifically required of it unless Tenant has previously notified Landlord, in writing, of the need for such repairs and Landlord has failed to commence and complete said repairs within a reasonable
time following receipt of Tenant's written notification; and if capital expenditures in excess of $1,000,000 are required during the term of the Lease (or $200,000 during the last two (2) years
of the term of the Lease), Landlord may terminate this Lease upon nine (9) months prior written notice to Tenant unless Tenant notifies Landlord in writing within ten (10) days after
receipt of Landlord's termination notice that Tenant will pay the cost of such expenditures. It is the intention of the parties that the terms of this Lease govern the respective obligations of the
parties as to maintenance and repair of the Premises. Tenant and Landlord expressly waive the benefit of any statute now or hereafter in effect to the extent it is inconsistent with the terms of this
Lease with respect to, or which affords Tenant the right to make repairs at the expense of Landlord or to terminate this Lease by reason of, any needed repairs. However, if Landlord fails to perform
any of Landlord's obligations under this paragraph 6.2 within a reasonable period after receipt of written notice of the need therefor from Tenant (or such shorter period as may be reasonably
appropriate in an "emergency situation", as hereinafter defined), and such failure results in either (i) a situation which materially and adversely affects the operation of Tenant's business
from the Premises or (ii) an emergency situation, then Tenant shall have the right, but not the obligation, to promptly take such measures as are necessary to cure such situation (using the
Building-standard subcontractors for any work on the Building roof, provided the applicable subcontractor is available at commercially reasonable and competitive rates for comparably experienced
subcontractors in the Palo Alto area given the work to be performed, and if such subcontractors are not so available, Tenant shall use for such work qualified, licensed contractors reasonably
experienced in performance of comparable work in comparable buildings), and Landlord shall reimburse Tenant for the reasonable costs of completing such cure. As used herein, an "emergency situation"
shall mean a situation where Landlord's failure to perform has resulted in an imminent risk of injury to persons or material property damage. 

        7.    Alterations.    

        7.1.    Landlord's Consent Required.    Tenant shall not, without Landlord's prior written consent, which shall not be
unreasonably withheld, delayed or conditioned, make any alterations, improvements or additions or utility installations (collectively called "alterations") in, on or about the Premises, except for
alterations which (i) in each case do not exceed Twenty-Five Thousand Dollars ($25,000) in cost or Fifty Thousand Dollars ($50,000) in cost in the aggregate in any calendar year;
(ii) are to the interior of the Building and do not affect the outside appearance of the Building; (iii) are nonstructural and do not impair the structural integrity of the Building; and 

16

 

(iv) do
not adversely affect the proper functioning of the building systems or other utilities, systems and services of the Building. Notwithstanding the forgoing, in no event shall Tenant
decrease the proportion of the Premises which constitute laboratories. As used in this paragraph 7.1, the term "utility installation" means power panels, wiring, conduits, air conditioning and
plumbing. If the estimated cost of the improvements exceeds $500,000, Landlord may require Tenant to provide Landlord, at Tenant's expense, a lien and completion bond in an amount equal to the
estimated cost of such alterations, or other reasonable assurance to insure Landlord against any liability for mechanic's and materialmen's liens and to insure completion of the work. Should Tenant
make any alterations which require Landlord's prior written consent without obtaining such prior written consent, Tenant shall upon demand by Landlord promptly remove the same and restore the Premises
to its original condition before such alterations, all at Tenant's expense. 

        7.2.    Plans and Permits.    Any alterations which Tenant shall desire to make in or about the Premises and which
require the prior written consent of Landlord shall be presented to Landlord in written form, with proposed detailed plans and specifications therefor prepared at Tenant's sole expense. Landlord shall
give its written approval or disapproval thereof within ten (10) days after receipt by Landlord, which approval or disapproval shall be reasonable. Any consent by Landlord thereto shall be
deemed conditioned upon Tenant's acquisition of all permits required to make such alteration from all appropriate governmental agencies, the furnishing of copies thereof to Landlord prior to
commencement of the work, and the compliance by Tenant with all conditions of said permits in a prompt and expeditious manner, all at Tenant's sole expense. Upon completion of any such alteration
which requires Landlord's consent and/or a permit, Tenant, at Tenant's sole cost, shall promptly deliver to Landlord "as-built" plans and specifications therefor. 

        7.3.    Construction Work Done by Tenant.    All construction work required or permitted to be done by Tenant shall be
performed by a licensed contractor and subcontractors (with respect to work to the Building HVAC, electrical and plumbing systems) approved by Landlord, which approval shall not be unreasonably
withheld, delayed or conditioned in a reasonably prompt, diligent, and good and workmanlike manner and shall conform in quality and design with the Premises existing as of the date of delivery of
possession to Tenant. All such construction work shall be performed in compliance with all applicable statutes, ordinances, regulations, codes and orders of governmental authorities and insurers of
the Premises. Tenant or its agents shall secure all licenses and permits necessary therefor and final approval thereof upon completion. Work, once started, shall be diligently pursued through to
completion in a good and workmanlike manner, in accordance with the plans and specifications approved by Landlord and in compliance with all Applicable Laws and insurance requirements. In connection
with alterations requiring Landlord's consent hereunder, no material changes shall be made to such plans and specifications as approved without the prior approval of Landlord, which approval shall not
be unreasonably withheld, delayed or conditioned. Throughout the performance of such alterations, Tenant, at its expense, shall carry, or cause to be carried by Tenant's contractor and its
subcontractors, in addition to the insurance described in paragraph 12, Workers' Compensation insurance in statutory limits and such other insurance as Landlord may reasonably require, with
insurers reasonably satisfactory to Landlord. Tenant shall furnish Landlord with satisfactory evidence that such insurance is in effect at or before the commencement of the alterations and, upon
request, at reasonable intervals thereafter until completion of the alterations. 

        7.4.    Title to Alterations.    Unless Landlord requires the removal thereof as set forth in paragraphs 7.1 or
7.5, any alterations which may be made on or to the Premises, shall be and remain the property of Tenant during the term of this Lease, and thereafter shall become the property of Landlord at the
expiration or sooner termination of the term of this Lease. Without limiting the generality of the foregoing, all heating, lighting, electrical (including all wiring, conduits, main and subpanels),
air conditioning, partitioning, drapery, and carpet installations made 

17

 

by
Tenant, regardless of how affixed to the Premises, together with all other alterations that have become an integral part of the Premises, shall be and become the property of Landlord at the
expiration or sooner termination of the term of this Lease, and shall not be deemed trade fixtures, and shall remain upon and be surrendered with the Premises at the expiration or sooner termination
of this Lease. Notwithstanding the provisions of this paragraph 7.4, Tenant's furnishings, furniture partitions and panels, trade fixtures, machinery and equipment, laboratory benches and
laboratory equipment (but excluding fume hoods installed as part of the initial tenant improvements in acccordance with the Work Letter, which fume hoods shall remain on the Premises), other than that
which is affixed to the Premises so that it cannot be removed without material damage to the Premises, shall remain the property of Tenant and may be removed by Tenant, provided Tenant at Tenant's
expense immediately after removal repairs any damage to the Premises caused thereby and, with respect to any fume hoods removed, removes any accessory ducting, wiring or other improvements or
alterations related thereto which Landlord requests that Tenant remove. 

        7.5.    Removal of Alterations.    Other than the initial tenant improvements made in acccordance with the Work
Letter, Tenant shall remove any alterations that Tenant has made to the Premises and restore the Premises as hereinafter provided unless Landlord notifies Tenant otherwise prior to the expiration of
the term of the Lease. If Landlord does not give such notice, Tenant shall, at its sole expense, prior to expiration of the lease term or within thirty (30) days after any sooner termination
thereof, remove such alterations, repair any damage occasioned thereby, and restore the Premises to the condition existing as of the date such alteration was made or, in the event of the removal of
existing improvements without the installation of any new improvements, as of the date such removal was undertaken. The obligations of Tenant set forth in this paragraph shall survive the termination
of this Lease. The terms of this paragraph 7 shall apply to the initial tenant improvements constructed by or on behalf of Tenant. 

        8.    Mechanics' Liens.    Tenant shall pay when due all claims for labor or materials furnished to or for Tenant at
or for use in the Premises, which claims are or may be secured by any mechanic's or materialman's lien against the Premises or any interest therein. Tenant shall give Landlord notice of the date of
commencement of any work in the Premises not less than ten (10) days prior thereto, and Landlord shall have the right to post notices of non-responsibility or similar notices in or
on the Premises in connection therewith. Tenant shall have the right to contest any such liens filed in good faith, provided that if any such liens are filed and not removed or bonded over within
fifteen (15) days after notice from Landlord, Landlord may, without waiving its rights and remedies based on such breach by Tenant and without releasing Tenant from any obligations, cause such
liens to be released by any means it deems proper, including payment in satisfaction of the claim giving rise to such lien. Tenant shall pay to Landlord upon demand any sum paid by Landlord to remove
such liens together with Landlord's costs and attorneys' fees and interest at the rate of ten percent (10%) per annum from the date of payment. 

        9.    Utilities; Janitorial and Security Services.    Tenant shall pay when due directly to the charging authority all
charges for water, gas, electricity, telephone, janitorial service, refuse pickup, and all other utilities and services supplied or furnished to the Premises during the term of this Lease, together
with any taxes thereon. In the event of an interruption in or failure or inability to provide any services or utilities to the Premises or Building for any reason (a "Service Failure"), such Service
Failure shall not, regardless of its duration, impose upon Landlord any liability whatsoever (except to the extent an interruption is caused by the Landlord's gross negligence or willful misconduct
and continues for ten consecutive days after Landlord receives notice from Tenant of such interruption), constitute an eviction of Tenant, constructive or otherwise, entitle Tenant to an abatement of
rent or to terminate this Lease or otherwise release Tenant from any of Tenant's obligations under this Lease. In no event shall Landlord be liable to Tenant for interruption of Tenant's business due
to failure or interruption of 

18

 

any
such utilities or services, unless such interruption (i)is caused by the gross negligence or willful misconduct of Landlord,(ii) continues for a period of three (3) days after
written notice by Tenant, (iii) Tenant has maintained its generator in good condition and has resorted to it to remedy any problem, and(iv) causes any damages to Tenant because of such
circumstance are not covered by Tenant's insurance. Subject to the foregoing, Tenant hereby waives any benefits of any applicable existing or future law, including the provisions of California Civil
Code Section 1932(1), permitting the termination of this Lease due to such interruption, failure or inability. Tenant shall be responsible for the janitorial service for the entire Building,
and shall maintain the Premises in clean condition. Landlord shall not be responsible for providing security guards or other security protection for all or any portion of the Premises, and Tenant may
at its own expense provide or obtain such security services as Tenant may desire to ensure the safety of the Premises. 

        10.    Indemnity.    Tenant shall indemnify, defend, protect and hold Landlord, its officers, directors, employees,
agents, lenders and their respective successors and assigns harmless from and against any and all claims, loss of rents, damages, losses, expenses (including, without limitation reasonable attorneys'
fees) or liabilities arising out of, involving, or in connection with the use and/or occupancy of the Premises by Tenant, any act or omission in or about the Premises by Tenant or any of its agents,
employees, contractors or invitees, or the Default by Tenant under this Lease. In the event any action or proceeding shall be brought against Landlord by reason of any of the foregoing matters, Tenant
upon notice from Landlord shall defend the same at Tenant's expense by counsel reasonably
satisfactory to Landlord. The obligations of Tenant contained in this paragraph shall survive the termination of this Lease. Notwithstanding the foregoing, the indemnity, defense and hold harmless
obligations of Tenant shall not apply to any claims, loss of rents, damages, losses, expenses or liabilities to the extent caused by the gross negligence or willful misconduct of Landlord or the
breach by Landlord of its obligations under this Lease. 

        11.    Waiver of Claims.    Tenant hereby waives any claims against Landlord, its officers, directors, employees,
agents, lenders and their respective successors and assigns for injury to Tenant's business or any loss of income therefrom or for damage to the goods, wares, merchandise or other property of Tenant,
or for injury or death of Tenant's agents, employees, invitees, or any other person in or about the Premises regardless of whether the same results from conditions existing upon the Premises or from
other sources or places, except to the extent that such claims result from the gross negligence or willful misconduct of Landlord. 

        12.    Insurance.    

        12.1.    Tenant's Liability Insurance.    Tenant shall, at Tenant's expense, obtain and keep in force during the term
of this Lease a policy of commercial general liability insurance insuring against liability arising out of the condition, use, occupancy or maintenance of the Premises. Such policy of insurance shall
have a combined single limit for both bodily injury and property damage in an amount not less than Five Million Dollars ($5,000,000) per occurrence. No more often than every three (3) years,
Landlord may require Tenant to increase the amount of such coverage if, in Landlord's reasonable opinion, the amount of such coverage is no longer adequate. The policy shall contain cross-liability or
equivalent endorsements. Tenant's liability insurance policy or policies shall: (i) include premises and operations liability coverage, products and completed operations liability coverage,
broad form property damage coverage including completed operations, blanket contractual liability coverage, and personal and advertising injury coverage; (ii) provide that the insurance company
has the duty to defend all insureds under the policy; (iii) provide that defense costs are paid in addition to and do not deplete any of the policy limits; (iv) cover liabilities arising
out of or incurred in connection with Tenant's use or occupancy of the Building and the other portions of the Premises; and (v) extend coverage to cover liability for the actions of Tenant's
representatives and invitees. Each policy of liability insurance required by this paragraph shall: (i) contain a cross liability endorsement or separation of insureds clause; 

19

 

(ii) provide
that any waiver of subrogation rights or release prior to a loss does not void coverage; and(iii) provide that it is primary to and not contributing with, any policy of
insurance carried by Landlord covering the same loss. The insurance requirements set forth herein are independent of Tenant's indemnification and other obligations under this Lease and shall not be
construed to restrict, limit or modify such indemnification or other obligations of Tenant under the Lease. 

        12.2.    Landlord's Liability Insurance.    Landlord shall maintain a policy or policies of commercial general
liability insurance insuring Landlord (and such other persons as may be designated by Landlord) against liability for personal injury, bodily injury or death, and damage to property occurring or
resulting from an occurrence in, on or about the Premises with a combined single limit in such form and in such amounts and including such coverages as Landlord deems appropriate, but in any event no
less than that required to be maintained by Tenant. Such policy may be a blanket policy also covering other properties owned by Landlord. 

        12.3.    Property Insurance.    

        (a)   Landlord
shall obtain and keep in force during the term of this Lease a policy or policies of insurance covering loss or damage to the Premises, but excluding coverage
of fixtures, machinery, equipment, alterations and leasehold improvements of Tenant which are not considered part of the real estate for insurance purposes, in the amount of the full replacement value
thereof, as the same may exist from time to time, or the amount required by any lender (but in no event more than the commercially reasonable and available insurance value thereof) providing
protection against all perils customarily included within the "all risk" or "special form" classification of causes of loss, and, at Landlord's option, flood, earthquake and additional costs resulting
from debris removal and the enforcement of any ordinance or law regulating the reconstruction or replacement of any undamaged sections of the Building required to be demolished or removed by reason of
the enforcement of any building, zoning, safety or land use laws as the result of a covered cause of loss. In addition, Landlord shall obtain and keep in force, during the term of this Lease, a policy
of rental loss insurance commencing on the date of loss and continuing for a period of at least one (1) year, with proceeds payable to Landlord, which insurance may also cover all Real Property
Taxes, insurance premiums, and other sums payable by Tenant to Landlord hereunder for said period. The insurance coverage may include sprinkler leakage insurance if the Building contains fire
sprinklers. Tenant shall have no interest in or right to the proceeds of any such insurance carried by Landlord. 

        (b)   Tenant
shall, at Tenant's sole expense, obtain and keep in force during the term of this Lease, a policy covering causes of loss-special form insuring the
fixtures, machinery, equipment, alterations, personal property and leasehold improvements of Tenant which are not considered part of the real estate for insurance purposes for the full replacement
value thereof, as the same may increase from time to time due to inflation or otherwise. The proceeds from any of such policies shall be used for the repair or replacement of such items so insured to
the extent that the same would become the property of Landlord upon the expiration or sooner termination of this Lease. Tenant may carry such insurance under a blanket policy, provided that such
policy provides coverage equivalent to a separate policy. Landlord shall be provided coverage under such insurance to the extent of its insurable interest and, if requested by Landlord, both Landlord
and Tenant shall sign all documents reasonably necessary or proper in connection with the settlement of any claim or loss under such insurance. Landlord shall have no obligation to carry insurance on
any of Tenant's personal or other property. 

20

 

 

        12.4.    Payment.    Tenant shall pay to Landlord the premiums for the insurance obtained by Landlord pursuant to
paragraphs 12.2 and 12.3(a). Landlord may obtain liability insurance and property insurance for the Premises separately, or together with other buildings and improvements under blanket policies
of insurance. In the latter case, Tenant shall be liable for only such portion of the premiums for such blanket policies as are allocable to the Premises, as reasonably determined by the insurer or
Landlord. If the term of this Lease does not expire concurrently with the expiration of the period covered by such insurance, Tenant's liability for premiums shall be prorated on an annual basis. 

        12.5.    Insurance Policies.    The insurance required to be obtained by Tenant pursuant to paragraphs 12.1 and
12.3(b) shall: (i) be primary insurance; (ii) name Landlord, Landlord's property manager and such other parties in interest as Landlord may from time to time reasonably designate
to Tenant in writing as an additional insured by endorsement, with such endorsement to be on such form and with such modifications as Landlord may require (with such additional insureds being provided
at least the same extent of coverage as is provided to Tenant under such policies and all endorsements effecting such additional insured status being at least as broad as additional insured
endorsement form number CG 2010 11 85 promulgated by the Insurance Services Office); (iii) be maintained at Tenant's sole cost and; (iv) be in a form
reasonably satisfactory to Landlord, which form may be a blanket policy; (v) be carried with companies admitted to do business in California, rated by the latest edition of the A.M. Best
Insurance Guide as A-VIII or better (or such other rating as may be required by any lender); and (vi) provide that the deductible amount under such insurance shall not exceed
$25,000. The policy or policies, or duly executed certificates for them, shall be deposited with Landlord on or prior to the date Tenant takes possession of the Premises. Each policy shall provide for
the carrier to provide at least thirty (30) days prior written notice to Landlord of cancellation or non-renewal. At least thirty (30) days prior to the expiration of any
required insurance policy, Tenant shall furnish Landlord with proof that a new policy has been issued, continuing in force the insurance covered by the policy which is expiring. In addition, Tenant
shall at Landlord's request provide to Landlord evidence that the insurance required to be carried by Tenant pursuant to this Lease, including any endorsement effecting the additional insured status,
is in full force and effect and that the premiums therefor have been paid when due. Tenant shall not do or permit to be done anything which shall invalidate any of the insurance policies referred to
in paragraphs 12.1, 12.2, and 12.3. 

        12.6.    Waiver of Subrogation.    Tenant and Landlord each hereby waives any and all rights of recovery against the
other, or against the officers, directors, employees, agents and representatives of the other, for loss of or damage to the property of the waiving party or the property of others under its control
regardless of the cause (including negligence of the party benefiting from the waiver), where such loss or damage is insured against under any insurance policy carried by Landlord or Tenant and in
force at the time of such loss or damage. Tenant and Landlord shall, upon obtaining the policies of insurance required hereunder, give notice to the insurance carrier or carriers that the foregoing
mutual waiver of subrogation is contained in this Lease. Landlord and Tenant shall have their respective insurance companies waive any rights of subrogation that such companies may have against
Landlord or Tenant, as the case may be. 

        12.7.    No Limitation of Liability.    Landlord makes no representation that the limits of liability specified to be
carried by Tenant or Landlord under the terms of this Lease are adequate to protect any party. If Tenant believes that the insurance coverage required under this Lease is insufficient to adequately
protect Tenant, Tenant shall provide, at its own expense, such additional insurance as Tenant deems adequate. 

21

 

        13.    Damage or Destruction.    

        13.1.    Partial Damage-Insured.    Subject to the provisions of paragraphs 13.2 and 13.3, if the Premises or
the Building, as the case may be, are damaged and such damage was caused by an act or casualty covered under an insurance policy required to be maintained pursuant to paragraph 12.3(a),
Landlord shall cause such damage to be repaired as soon as reasonably possible and this Lease shall continue in full force and effect. 

        13.2.    Landlord's Right to Terminate.    Landlord may elect to terminate this Lease following damage by fire or
other casualty, effective as of the date of the occurrence of such damage, under the following circumstances: (i) if in Landlord's reasonable judgment the Building cannot be substantially
repaired and restored under Applicable Laws within six (6) months from the date of the casualty; (ii) if adequate insurance proceeds are not for any reason (other than Landlord's failure
to obtain coverages required pursuant to paragraph 12.3(a)), including, without limitation, the casualty not being a casualty for which Landlord is required to maintain insurance pursuant to
paragraph 12.3(a) or a decision made by any holder of any encumbrance covering any part of the Premises, not to make available to Landlord from Landlord's insurance policies (and/or from
Landlord's funds made available for such purpose, in Landlord's sole and absolute discretion) an amount sufficient to cover all of the cost of the required repairs (excluding the deductible under the
policy); (iii) if the Building is damaged or destroyed to the extent that, in the reasonable judgment of Landlord, the cost to repair and restore the Building would exceed fifty percent (50%)
of the full replacement cost of the Building; (iv) if the fire or other casualty occurs during the last one (1) year of the term of the Lease and the damage to the Building is material;
or (v) if the casualty is caused by earthquake and the deductible amount payable under Landlord's earthquake insurance policy exceeds $100,000. 

If
any of the circumstances described in subparagraphs (i), (ii), (iii) or (iv) of this paragraph 13.3 occur or arise, Landlord shall give Tenant notice within sixty
(60) days after the date of the casualty, specifying whether Landlord elects to terminate this Lease as provided above or Landlord's estimate of the time required to complete Landlord's repair
obligations if more than nine (9) months from the date of the casualty. In the event Landlord elects to terminate this Lease, this Lease shall be terminated effective as of the date of such
casualty pursuant to such notice of termination by Landlord. 

        13.3.    Tenant's Right to Terminate.    If (i) all or a substantial part of the Building is rendered
untenantable or inaccessible by damage from fire or other casualty, then Tenant may elect to terminate this Lease if Landlord's estimate of the time required to complete Landlord's repair obligations
under this Lease is greater than nine (9) months from the date of the casualty, or (ii) the fire or other casualty occurs during the last one (1) year of the term of the Lease and
the damage to the Building is material; in each of such events, Tenant may terminate this Lease by giving Landlord notice of Tenant's election to terminate within fifteen (15) days after
Landlord's notice to Tenant pursuant to paragraph 13.2, in the case of an event described in clause (i) or within thirty (30) days after an event described in clause (ii).
If Tenant elects to terminate this Lease, the Lease shall terminate effective as of the date of such casualty. 

        13.4.    Abatement of Rent.    Notwithstanding anything to the contrary contained in paragraph 3 or elsewhere
in this Lease, if the Premises are damaged such that they become unusable or partially unusable by Tenant, the rent payable hereunder for the period commencing on the occurrence of such damage and
ending upon completion of such repair or restoration shall be abated in proportion to the extent to which Tenant's use of the Premises is impaired; provided that nothing herein shall be construed to
preclude Landlord from being entitled to collect the full amount of any rental loss insurance proceeds. Except for abatement of rent, if any, Tenant shall 

22

 

have
no claim against Landlord for any damage suffered by reason of any such damage, destruction, repair or restoration, except as explicitly provided herein. 

        13.5.    Tenant's Property.    Landlord's obligation to rebuild or restore shall not include restoration of Tenant's
trade fixtures, equipment, merchandise, or any improvements, alterations or additions made by Tenant to the Premises. 

        13.6.    Notice of Damage.    Tenant shall notify Landlord within ten (10) days after the occurrence thereof of
any damage to all or any portion of the Premises. In no event shall Landlord have any obligation to repair or restore the Premises pursuant to this paragraph 13 until a reasonable period of
time after Landlord has reasonable period of time to collect insurance proceeds arising from such damage (unless
such damage is clearly not covered by insurance then in effect covering the Premises), not to exceed one hundred and eighty (180) days. 

        13.7    Waiver of Statutes.    The terms of this Lease shall govern the effect of any damage to or destruction of the
Premises with respect to the termination of this Lease. Landlord and Tenant hereby waive the provisions of California Civil Code Sections 1932(2), 1933(4) and any other present or future
statute to the extent inconsistent herewith. 

        14.    Condemnation.    

        14.1.    Partial Taking.    Subject to the provisions of paragraph 14.2, if part of the Premises is taken for
any public or quasi-public use, under any statute or right of eminent domain (collectively a "taking"), and a part of the Premises remains which is reasonably suitable for Tenant's continued occupancy
for the uses permitted by this Lease, this Lease shall, as to the part so taken, terminate as of the date the condemnor or purchaser takes possession of the property being taken, and the rent payable
hereunder shall be reduced based upon the extent to which the partial taking shall interfere with the business carried on by Tenant on the Premises. Landlord shall, at its own cost and expense, make
all necessary repairs or alterations to the Premises in order to make the portion of the Premises not taken a complete architectural unit; provided, however, that Landlord shall not be required to
repair or restore any injury or damage to the property of Tenant or to make any repairs or restoration of any alterations, additions, fixtures or improvements installed on the Premises by or at the
expense of Tenant. 

        14.2.    Total Taking.    If fifteen percent (15%) or more of the floor area of the Building is taken, or more than
twenty five percent (25%) of the land area is taken, or such part thereof is taken so that there does not remain a portion of the Premises suitable for Tenant's continued occupancy for the uses
permitted hereunder, such taking shall be treated as a total taking and this Lease shall terminate upon the date possession shall be taken by the condemning authority. 

        14.3.    Distribution of Award.    If a part or all of the Premises is taken, all compensation awarded upon such
taking shall belong to and be paid to Landlord, except that Tenant shall receive from the award a sum attributable to Tenant's improvements or alterations made to the Premises by Tenant at Tenant's
expense which Tenant has the right to remove from the Premises pursuant to the provisions of this Lease; or, if Tenant elects to remove any such improvements or alterations made to the Premises at
Tenant's expense, Tenant shall receive a sum for reasonable removal and relocation costs not to exceed the market value of such improvements or alterations on the date possession of the Premises is
taken. Notwithstanding the foregoing, Tenant shall have the right to seek a claim against the taking authority for interruption of or damage to its business and loss of business goodwill and moving
expenses. 

        14.4.    Sale Under Threat of Condemnation.    A sale by Landlord to any authority having the power of eminent domain,
either under threat of condemnation or while condemnation proceedings are pending, shall be deemed a taking under the power of eminent domain for purposes of this paragraph 14. 

23

 

        14.5.    Waiver of Statutes.    The terms of this Lease shall govern the effect of any taking of the Premises.
Landlord and Tenant hereby waive the provisions of California Code of Civil Procedure Section 1265.130 and any other present or future statute to the extent inconsistent herewith. 

        15.    Assignment and Subletting.    

        15.1.    Landlord's Consent Required.    Tenant shall not assign this Lease, or any interest therein, voluntarily or
involuntarily, and shall not sublet the Premises or any part thereof, or any right or privilege appurtenant thereto, or suffer any other person to occupy or use the Premises, or any portion thereof,
without the prior written consent of Landlord in each instance pursuant to the terms and conditions set forth below, which consent shall not be unreasonably withheld, delayed or conditioned. 

        15.2.    Documentation.    Prior to any assignment or sublease which Tenant desires to make, Tenant shall provide to
Landlord: (i) the name and address of the proposed assignee or sublessee, (ii) true and complete copies of all documents evidencing Tenant's prospective agreement to assign or sublease,
(iii) such other information as may be reasonably requested by Landlord, and (iv) a document signed by Tenant and the proposed assignee or sublessee specifying to Landlord's reasonable
satisfaction all consideration to be received by Tenant in connection with such assignment or sublease in the form of lump sum payments, installments of rent, or otherwise. For purposes of this
paragraph 15, the term "consideration" shall include, without limitation, all monies or other consideration of any kind, if such sums are related to Tenant's interest in this Lease or in the
Premises, including but not limited to, bonus money, and payments (in excess of fair market value thereof) for Tenant's assets, fixtures, equipment or furniture remaining in the Premises. 

        15.3.    Terms and Conditions.    As a condition to Landlord's granting its consent to any assignment or sublease,
Landlord may require that (i) Tenant pay to Landlord, as and when received by Tenant, one-half of the amount of any excess of such consideration to be received by Tenant in
connection with said assignment or subletting over and above the base rent required to be paid by Tenant for the same month in which the consideration is received (calculated on a per square foot
basis if less than all of the Premises is assigned or sublet); provided that Tenant shall first be entitled to retain an amount of such excess consideration equal to Tenant's reasonable direct costs
of the real estate brokerage commissions and attorney's fees incurred by Tenant in connection with such assignment or subletting and the cost of tenant improvements and alterations made for the
assignee or sublessee and paid for by Tenant amortized on a straight line basis over the remaining term of the Lease (or the term of the sublease in the case of a sublease); and (ii) Tenant and
the proposed assignee or sublessee demonstrate to Landlord's reasonable satisfaction that the assignee or sublessee proposes to use the Premises for substantially the same use or a use which is
otherwise satisfactory to Landlord. Each assignment or sublease agreement to which Landlord has consented shall be an instrument in writing in form reasonably satisfactory to Landlord, and shall be
executed by both Tenant and the assignee or sublessee, as the case may be. Each such assignment or sublease agreement shall recite as follows (collectively, the "Required Provisions"): (i) if a
sublease, that it is and shall be subject and subordinate to the provisions of this Lease, (ii) the assignee or sublessee accepts such assignment or sublease and agrees to perform all of the
obligations of Tenant hereunder or those applicable to the subleased Premises in the case of a sublease of a portion of the Premises, (iii) the termination of this Lease shall, at Landlord's
sole election, constitute a termination of every such assignment or sublease, (iv) if a sublease, in the event of a Default by Tenant, at Landlord's sole election, the sublessee shall attorn to
Landlord (in which event Landlord shall undertake the obligations of Tenant under such sublease arising after the exercise of such option; provided, however, that Landlord shall not be liable for any
prepaid rents or security deposit paid by such sublessee to Tenant or for any prior defaults or breaches by Tenant), (v) if a sublease, any matter requiring the consent of the Tenant 

24

 

under
the sublease shall also require the consent of Landlord; and (vi) the terms of this paragraph 15 shall apply to any further assignment or subletting of all of any part of the
Premises by any future assignee or sublessee. In the event Landlord shall consent to an assignment or sublease, Tenant shall nonetheless remain liable for all obligations and liabilities of Tenant
under this Lease, including, but not limited to, the payment of rent. The consent by Landlord to any assignment or sublease shall not constitute a waiver of the provisions of this paragraph 15,
including the requirement of Landlord's prior written consent, with respect to any subsequent assignment or sublease. Tenant agrees to reimburse Landlord upon demand for reasonable attorneys' fees
incurred by Landlord in connection with the negotiation, review, and documentation of any such requested assignment or subleasing, not to exceed $5,000. 

        15.4.    Corporate Transactions Constituting Assignment.    

        (a)   Any
dissolution, merger, reorganization, transfer (either all at once or any time in the aggregate) of fifty percent (50%) or more of the capital stock, partnership
interests or membership interests of Tenant (if Tenant is a corporation, partnership or limited liability company, respectively), or sale (either all at once or in a series of related sales) of all or
substantially all of Tenant's assets located in, on, or about the Premises, shall be deemed an assignment. Notwithstanding the foregoing. if Tenant is deemed to be a Reporting Company under the
Securities and Exchange Act of 1934, the sale of more than fifty
(50%) per cent of Tenant's capital stock to a single entity or to related entities in a single transaction or series of related transactions shall be deemed to be an assignment. 

        (b)   Notwithstanding
the foregoing, Tenant may, without Landlord's prior written consent, without any participation by Landlord in assignment and subletting proceeds, and
without giving Landlord any recapture rights, sublet the premises or assign this Lease to: (i) an entity controlling, controlled by or under common control with Tenant; (ii) a transferee
which is the resulting entity of a merger, consolidation or non-bankruptcy reorganization with Tenant; or (iii) a purchaser of all or substantially all of Tenant's stock or assets.
Tenant's foregoing rights to assign or sublease this Lease without Landlord's prior written consent shall be subject to the following conditions: (A) Tenant shall not be in uncured Default
hereunder; (B) the assignment or sublease agreement shall contain the Required Provisions; (C) other than the requirement that Tenant obtain Landlord's consent and share with Landlord a
portion of the assignment or sublease proceeds and Landlord's recapture right, all of the provisions of this paragraph 15 shall apply with respect thereto (including, without limitation, that
Tenant shall remain liable for all obligations and liabilities of Tenant under this Lease); (D) Tenant shall provide at least thirty (30) days prior written notice to Landlord of any
such assignment or subletting and promptly supply Landlord with any documents or information reasonably requested by Landlord regarding such assignment or subletting or such assignee or sublessee
(provided, however, that in the event that Tenant can not legally deliver such 30 days notice, Tenant shall deliver such notice at the earliest time that it can legally do so; and
(E) the entity to which the Lease is assigned or subleased has a net worth as of the date of such assignment or sublease equal to at least the greater of the net worth of Tenant as of the date
of this Lease or as of the date immediately preceding such assignment or sublease. Tenant and the proposed assignee or sublessee shall provide such documentation as may be requested by Landlord to
demonstrate to Landlord's reasonable satisfaction that the condition set forth in (E) above has been satisfied. For the purposes of this Lease, the sale of Tenant's capital stock through any
public offering shall not be deemed an assignment, subletting, or other transfer of the Lease or the premises. 

        15.5    Recapture.    In addition to Landlord's right of approval of any proposed assignment or sublease and without
limiting the other provisions of this paragraph 15, Landlord shall have the option, in the event of any proposed Major Transfer to terminate the Lease. The term "Major 

25

 

Transfer"
as used in this Lease means an assignment or sublease which: (i) when combined with all other assignments or subleases (other than those subject to paragraph 15.4), means that
more than one half of the rentable square feet in the Building would be assigned or sublet; and (ii) either the proposed assignment or sublease (including all options to extend) together with
any prior assignment or sublease (including all options to extend) as of the date of the proposed assignment or sublease has a term of more than the lesser of (x) three (3) years ;
(y) one half of the remaining term of the Lease as of the date of the commencement of such assignment or sublease; or (z) if the date of the commencement of such assignment or sublease
is during the last three (3) years of the term of the Lease, one (1) year. If Tenant desires to determine prior to identifying a particular transaction whether Landlord intends to
exercise its recapture right, Tenant shall give Landlord written notice of Tenant's intent to enter into a Major Transfer as of the date specified in such notice (the "Major Transfer Date"), which
date shall be not less than six (6) months and not more than (9) months from the date of Landlord's receipt of such notice. Tenant shall not be required to have a particular assignment
or sublease identified before giving such notice; provided, however, that Tenant shall again comply with the provisions of this paragraph 15.5
with respect a Major Transfer in the event that: (i) Tenant does not enter into a Major Transfer by the Major Transfer Date; or (ii) any assignment or sublease which is not a Major
Transfer when executed later becomes one by means of any extension, expansion or otherwise (in which case Tenant shall immediately give Landlord written notice of such occurrence). Landlord shall
exercise its option to terminate, if at all, by giving Tenant written notice thereof within thirty (30) days following Landlord's receipt of Tenant's written notice. In the event that Landlord
exercises its option to terminate, the Lease shall terminate as of the Major Transfer Date or, in the event that the Major Transfer occurs as a result of any assignment or sublease which is not a
Major Transfer when executed later becoming one by means of any extension, expansion or otherwise, as of the date which is six (6) months after the date of the Major Transfer. Without in any
manner limiting the rights of Landlord, following any such termination by Landlord, Landlord may lease all or a portion of the Premises to any prospective assignee or subtenant proposed by Tenant,
without liability to the Tenant. Landlord's failure to exercise such termination right as herein provided shall not be construed as a waiver of Landlord's right with respect to any other assignment or
sublease constituting a Major Transaction or as Landlord's consent to any proposed assignment or subletting and Tenant shall comply with the terms of this paragraph 15 with respect thereto. 

        15.6.    Landlord's Remedies.    Any assignment or sublease without Landlord's prior written consent (if required
pursuant to this paragraph 15) shall at Landlord's election be void, and shall constitute a default. If Tenant shall purport to assign this Lease, or sublease all or any portion of the
Premises, or permit any person or persons other than Tenant to occupy the Premises without Landlord's prior written consent, Landlord may collect rent from the person or persons then or thereafter
occupying the Premises and apply the net amount collected to the rent reserved herein, but no such collection shall be deemed a waiver of Landlord's rights and remedies under this paragraph 15,
or the acceptance of any such purported assignee, sublessee or occupant, or a release of Tenant from the further performance by Tenant of covenants on the part of Tenant herein contained. 

        15.7.    Encumbrances, Licenses and Concession Agreements.    Except as permitted herein, Tenant shall not encumber
its interest under this Lease or any rights of Tenant hereunder, or enter into any license or concession agreement respecting all or any portion of the Premises, without Landlord's prior written
consent which consent shall not unreasonably be withheld or delayed subject to the terms and conditions referred to in paragraph 15.2 above, and Tenant's granting of any such encumbrance,
license, or concession agreement shall constitute an assignment for purposes of this paragraph 15. 

26

 

        16.    Default by Tenant.    

        16.1.    Event of Default.    The occurrence of any one or more of the following events (an "Event of Default") shall
constitute a default and breach of this Lease by Tenant: 

        (a)   The
failure by Tenant to make any payment of rent or any other payment required to be made by Tenant hereunder, as and when due, and such failure shall not have been
cured within five (5) days after Tenant receives written notice thereof from Landlord; 

        (b)   Tenant's
failure to perform any other term, covenant or condition contained in this Lease and such failure shall have continued for thirty (30) days after written
notice of such failure is given to Tenant; provided that, where such failure cannot reasonably be cured within said thirty (30) day period, Tenant shall not be in default if Tenant commences
such cure within said thirty (30) day period and thereafter diligently continues to pursue all reasonable efforts to complete said cure until completion thereof. Said written notice shall
constitute those required under California Code of Civil Procedure, Section 1161, et seq.; 

        (c)   Tenant
abandons the Premises for more than thirty (30) days or violates the restrictions on assignment or subletting in paragraph 15; 

        (d)   Tenant
ceases doing business as a going concern; makes an assignment for the benefit of creditors; is adjudicated an insolvent, files a petition (or files an
answer admitting the material allegations of a petition) seeking relief under any state or federal bankruptcy or other statute, law or regulation affecting creditors' rights; all or substantially all
of Tenant's assets are subject to judicial seizure or attachment and are not released within 60 days, or Tenant consents to or acquiesces in the appointment of a trustee, receiver or liquidator
for Tenant or for all or any substantial part of Tenant's assets. 

        (e)   Tenant
fails, within sixty (60) days after the commencement of any proceedings against Tenant seeking relief under any state or federal bankruptcy or other
statute, law or regulation affecting creditors' rights, to have such proceedings dismissed, or Tenant fails, within thirty (30) days after an appointment, without Tenant's consent or
acquiescence, of any trustee, receiver or liquidator for Tenant or for all or any substantial part of Tenant's assets, to have such appointment vacated. 

        16.2.    Remedies.    Upon any Event of Default, Landlord shall have the following remedies in addition to all other
rights and remedies provided by law or equity: 

        (a)   The
rights and remedies provided by California Civil Code Section 1951.4 (Landlord may continue the lease in effect after Tenant's breach and abandonment and
recover rent as it becomes due, if Tenant has right to sublet or assign, subject only to reasonable limitations). Acts of maintenance or preservation, efforts to relet the premises, or the appointment
of a receiver upon Landlord's initiative to protect its interest under this Lease shall not constitute a termination of Tenant's right to possession;; or 

        (b)   Landlord
may terminate the Tenant's right to possession by giving Tenant thirty (30) days written notice of termination. Thirty (30) days after the giving
of the notice, this Lease and all of Tenant's rights in the Premises shall terminate. Any termination under this paragraph shall not release Tenant from the payment of any sum then due Landlord or
from any claim for damages or rent previously accrued or then accruing against Tenant. 

27

 

        Tenant
hereby waives its right under California Code of Civil Procedure Section 1179. In the event this Lease is terminated pursuant to this paragraph 16.2(b), Landlord may
recover from Tenant: 

          (i)  the
worth at the time of award of the unpaid rent which had been earned at the time of termination; plus 

         (ii)  the
worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time of award exceeds the amount of such
rental loss for the same period that Tenant proves could have been reasonably avoided; plus 

        (iii)  the
worth at the time of award of the amount by which the unpaid rent for the balance of the term after the time of award exceeds the amount of such rental loss for
the same period that Tenant proves could be reasonably avoided; plus 

        (iv)  any
other amount necessary to compensate Landlord for all detriment proximately caused by Tenant's failure to perform Tenant's obligations under this Lease, or which in
the ordinary course of things would be likely to result therefrom. 

        The
"worth at the time of award" of the amounts referred to in subparagraphs (i) and (ii) of this paragraph 16.2(b) shall be computed by allowing interest at the greater of
ten percent (10%) per annum or the Bank of America reference rate as of the date thereof plus two percent (2%) per annum. The "worth at the time of the award" of the amount referred to in
subparagraph (iii) of this paragraph 16.2(b) shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of the
award plus one percent (1%). The term "time of award" as used in subparagraphs (i), (ii) and (iii) shall mean the date of entry of a judgment or award against Tenant in an action or proceeding
arising out of Tenant's breach of this Lease. The term "rent" as used in this paragraph shall include all sums required to be paid by Tenant to Landlord pursuant to the terms of this Lease. 

        (c)   Upon
any termination of Tenant's possession of the Premises or the abandonment of the Premises by Tenant, Landlord may remove all Tenant's property from the Premises,
and such property may be stored by Landlord in a public warehouse or elsewhere at the sole cost and for the account of Tenant. If Landlord does not elect to store any or all of Tenant's property left
in the Premises, Landlord may consider such property to be abandoned by Tenant, and Landlord may thereupon dispose of such property in any manner deemed appropriate by Landlord. Any proceeds realized
by Landlord on the disposal of any such property shall be applied first to offset all expenses of storage and sale, then credited against Tenant's outstanding obligations to Landlord under this Lease,
and any balance remaining after satisfaction of all obligations of Tenant under this Lease shall be delivered to Tenant. 

        (d)   This
Lease may be terminated by a judgment specifically providing for termination, or by Landlord's delivery to Tenant of written notice specifically terminating this
Lease in accordance with applicable law. In no event shall any one or more of the following actions by Landlord alone, in the absence of a written election by Landlord to terminate this Lease,
constitute a termination of this Lease or a waiver of Landlord's right to recover damages under this paragraph 16: 

          (i)  appointment
of a receiver in order to protect Landlord's interest hereunder; 

         (ii)  consent
to any subletting of the Premises or assignment of this Lease by Tenant, whether pursuant to provisions hereof concerning subletting and assignment or
otherwise; or 

28

 

        (iii)  any
other action by Landlord or Landlord's agents intended to mitigate the adverse effects of any breach of this Lease by Tenant, including without limitation any
action taken to maintain and preserve the Premises or any action taken to relet the Premises or any portion thereof for the account of Tenant and in the name of Tenant. 

        16.3.    Landlord's Right to Perform Tenant's Obligations.    If Tenant shall at any time fail to make any payment or
perform any other act required to be made or performed by Tenant under this Lease, then after the cure period provided herein and after reasonable notice to Tenant, Landlord may, but shall not be
obligated to, make such payment or perform such other act to the extent Landlord may deem desirable, and may, in connection therewith, pay any and all expenses incidental thereto and employ counsel.
No such action by Landlord shall be deemed a waiver by Landlord of any rights or remedies Landlord may have as a result of such failure by Tenant, or a release of Tenant from performance of such
obligation. All sums so paid by Landlord, including without limitation all penalties, interest and costs in connection therewith, shall be due and payable by Tenant to Landlord on the day immediately
following notice to Tenant of any such payment by Landlord. Landlord shall have the same rights and
remedies for the nonpayment of any such sums as Landlord may be entitled to in the case of default by Tenant in the payment of rent. 

        16.4.    Interest on Past Due Obligations.    Any amount due to Landlord hereunder and not paid within the cure period
provided herein shall bear interest at the lesser annual rate of (i) ten percent (10%); or (ii) the highest rate then allowed by law, from the date due until paid in full. Payment of
such interest shall not excuse or cure any default by Tenant under this Lease. 

        16.5.    Additional Rent.    All sums payable by Tenant to Landlord or to third parties under this Lease shall be
payable as additional sums of rent. For purposes of any unlawful detainer action by Landlord against Tenant pursuant to California Code of Civil Procedure Sections 1161-1174, or any
similar or successor statutes, Landlord shall be entitled to recover as rent not only such sums specified in paragraph 3 as may then be overdue, but also all such additional sums of rent as may
then be overdue. 

        16.6    Notice Requirements.    When this Lease requires service of a notice, that notice shall replace rather than
supplement any equivalent or similar statutory notice, including any notices required by Code of Civil Procedure Section 1161 or any similar or successor statute. When a statute requires
service of a notice in a particular manner, service of that notice (or a similar notice required by this Lease) in the manner required by paragraph 22 shall replace and satisfy statutory
service-of-notice procedures, including those required by Code of Civil Procedure Section 1162 or any similar or successor statute 

        16.7.    Remedies Not Exclusive.    No remedy or election hereunder shall be deemed exclusive but shall, wherever
possible, be cumulative with all other remedies herein provided or permitted at law or in equity. 

        17.    Default by Landlord.    

        17.1.    Cure Period.    Landlord shall not be deemed to be in default in the performance of any obligation required
to be performed by it hereunder unless and until it has failed to perform such obligation within the period of time specifically provided herein, or if no period of time has been provided, then within
thirty (30) days after receipt of written notice by Tenant to Landlord specifying wherein Landlord has failed to perform such obligation; provided, however, that if the nature of Landlord's
obligation is such that more than thirty (30) days are reasonably required for its performance, then Landlord shall not be deemed to be in default if it shall commence such performance within
such thirty (30) day period and thereafter diligently prosecute the same to completion. 

29

 

 

        17.2.    Mortgagee Protection.    If any deed of trust or mortgage encumbers the Premises, in the event of any default
on the part of Landlord, Tenant will give notice by registered or certified mail to any beneficiary of a deed of trust or mortgagee of a mortgage encumbering the Premises whose address shall have been
furnished to Tenant and before Tenant shall have any right to terminate this Lease Tenant shall grant such beneficiary or mortgagee a reasonable period within which to cure the default, including a
reasonable period to obtain possession of the Premises by private power of sale if such action is necessary to effect a cure. The provisions of this Lease may require approval by a financial
institution making a loan secured by the Premises. If any such institution should require as a condition to such financing any modification of the provisions of this Lease, Tenant will approve and
execute such modifications provided no such modification shall relate to the rent payable hereunder, the length of the term or materially alter the rights or obligations of Landlord or Tenant. 

        18.    Advertisements and Signs.    Tenant shall not place or permit to be placed any sign, display, advertisement, or
decoration ("sign") on the exterior of the Building, or elsewhere on the Premises, without all necessary approvals from the City of Palo Alto and the prior written consent of Landlord, which consent
shall not be unreasonably withheld, as to the color, size, style, character, content, and location of each such sign. The cost of Tenant's sign(s) and their installation, maintenance and removal
(including any necessary repairs to the Building or any other part of the Premises caused by such removal) shall be Tenant's sole cost and expense. Upon termination of this Lease, Tenant shall remove
any sign which it has placed on the Premises or the Building, and shall repair any damage caused by the installation or removal of such sign. 

        19.    Entry by Landlord.    Landlord and its agents shall be entitled to enter into and upon the Premises at all
reasonable times upon reasonable notice (except in the case of an emergency, in which event no notice shall be required), for purposes of (i)exercising its rights under this Lease; (ii) posting
notices of non-responsibility for alterations, additions, or repairs, (iii) during the final year of the lease term for the purpose of placing upon the Premises any ordinary "for
sale" signs, and during the one hundred eight (180) day period prior to the expiration of this Lease, to place upon the Premises any usual or ordinary "for lease" signs and exhibit the Premises
to prospective tenants at reasonable hours; (iv)determining whether the Premises are in good condition; (v) performing any maintenance or repair of the Building or Premises that Landlord has
the right or obligation to perform; (vi) determining whether Tenant is complying with its obligations under this Lease (including, without limitation, its
obligations under paragraph 5); or(vii) doing any other act or thing necessary for the safety or preservation of the Building or the Premises, all without any abatement of rent and
without liability to Tenant for any injury or inconvenience to or interference with Tenant's business, quiet enjoyment of the Premises, or any other loss occasioned thereby, except for Landlord's
gross negligence or willful misconduct. Landlord's rights of entry as set forth in this paragraph shall be subject to the reasonable security regulations of Tenant and good laboratory practices as
determined by Tenant, and to the requirement that Landlord shall at all times act in a manner designed to minimize interference with Tenant's business activities on the Premises. 

        20.    Subordination and Attornment.    

        20.1.    Subordination.    This Lease shall be subject and subordinate to any mortgage, deed of trust, ground lease or
other instrument of security now of record or which is recorded after the date of this Lease affecting the land and Building, or land or Building, of which the Premises form a part, and such
subordination is hereby made effective without any further act of Tenant; provided that such subordination shall not be effective with respect to any mortgage, deed of trust, ground lease or other
instrument or security recorded after the date of this Lease unless Landlord first obtains from the lender or ground lessor a written agreement that provides in essence that as long as Tenant performs
its obligations under this Lease within any applicable notice and cure periods, no foreclosure of, deed given in lieu of foreclosure, or sale under the encumbrance, and no steps 

30

 

or
procedures taken under the encumbrance, shall affect Tenant's rights or increase Tenant's obligations under this Lease. Tenant shall execute and deliver to Landlord any written agreement and any
other documents reasonably required by the lender or ground lessor to accomplish the purposes of this paragraph, within ten (10) days after delivery thereof to Tenant; provided that, in any
case where Tenant is entitled to the above-described nondisturbance agreement, either prior to or concurrently with the request Tenant is provided the required nondisturbance agreement by the lender
or ground lessor. Anything in this paragraph 20.1 to the contrary notwithstanding, if a lender so elects in writing, this Lease shall be deemed superior to the lien held by the lender,
regardless of the date of recordation of the lien, and Tenant will execute an agreement confirming the lender's election on request. Landlord represents that there is no loan currently outstanding
which is secured by the Premises. 

        20.2.    Attornment.    Subject to the foregoing paragraph 20.1, Tenant shall attorn to any third party
purchasing or otherwise acquiring the Premises at any sale or other proceeding, or pursuant to the exercise of any rights, powers or remedies under any mortgages or deeds of trust or ground leases now
or hereafter encumbering all or any part of the Premises, as if such third party had been named as Landlord under this Lease. 

        21.    Estoppel Certificates and Financial Statements.    

        21.1.    Estoppel Certificates.    Tenant shall, within ten (10) days following request by Landlord, execute
and deliver any documents, including estoppel certificates, in any reasonable form presented by Landlord: (i) certifying that this Lease has not been modified or, if modified, stating the
nature of such modification and certifying that this Lease, as so modified, is in full force and effect, (ii) stating the date to which the rent and other charges are paid in advance, if at
all, (iii) acknowledging that there are not, to Tenant's knowledge, any uncured defaults on the part of either party hereunder, or if there are uncured defaults, stating the nature of such
uncured defaults, (iv) evidencing the status, to Tenant's knowledge, of this Lease (with respect the subordination thereof or any other matter) as may be required either by a lender making a
loan to be secured by a deed of trust or mortgage encumbering the Premises or a purchaser of the Premises from Landlord; and (v) stating any other information as Landlord may reasonably
request. Any person or entity purchasing, acquiring an interest in or extending financing with respect to the Premises shall be entitled to rely upon any such certificate. If Tenant fails to deliver
such certificate within five (5) days after Landlord's second written request therefor, Tenant shall be liable to Landlord for any damages incurred by Landlord, including any profits or other
benefits from any sale or financing of the Premises or any interest therein which are lost or made unavailable as a result, directly or indirectly, of Tenant's failure or refusal to timely execute or
deliver such estoppel certificate. 

        21.2.    Financial Statements    Within ten (10) days after written request therefor, which request shall not
be made more frequently than twice per year, Tenant shall deliver to Landlord a copy of Tenant's most current financial statements (including at least a year end balance sheet and a statement of
operations) of Tenant (and of each guarantor, if any, of Tenant's obligations under this Lease) and for each of the three most recently completed years (if available), prepared in accordance with
generally accepted accounting principles (and, if such is Tenant's normal practice, audited by an independent certified public accountant), all then available subsequent quarterly statements, and such
other financial information as may reasonably be requested by Landlord or required by any lender. This requirement shall not apply in any period during which Tenant is a "reporting company" as defined
in the Securities and Exchange Act of 1934. 

        22.    Notices.    Any notice, approval, request, demand or consent (collectively "notice") required or desired to be
given under this Lease shall be in writing and shall be delivered (i) by United States mail, registered or certified, postage prepaid, (ii) by a recognized courier service with proof of
delivery and 

31

 

addressed
to the party to be served at the last address given by that party to the other party under the provisions of this paragraph, or (iii) by receipted facsimile to the number indicated
below, with a hard copy delivered in accordance with clauses (i) or (ii). At the date of execution of this Lease, the addresses of Landlord and Tenant are as set forth below: 

 

 

			
	Landlord:	 	 California Pacific

Commercial Corporation

2200 Sand Hill Road, Suite 230

Menlo Park, CA 94025

Attn: Dan McGanney III,

President

Facsimile:
	
With a copy to:	
 	
 Stephen L. Englert

Epstein, Englert, Staley & Coffey

425 California Street, 17th Floor

San Francisco, CA 94104

Facsimile: (415) 398-6938
	
Tenant:	
 	
 Anacor Pharmaceuticals, Inc.
	
Prior to the

Commencement Date:	
 	

1060 East Meadow Circle

Palo Alto, CA 94303-4230

Attn: Chief Financial Officer

Facsimile: (650) 424-8144
	
Following the

Commencement Date:	
 	
 At the Premises
	
With a copy to:	
 	
 Greenberg Traurig, LLP

1900 University Avenue

East Palo Alto, CA 94303

Attn: Toni Pryor Wise

Facsimile: (650) 426-7887

 

 Any
notice delivered by mail pursuant to this paragraph shall be deemed to have been delivered three (3) business days after the posted date of mailing. 

        23.    Waiver.    The waiver by either party of any breach of any term, covenant, or condition herein contained shall
not be deemed to be a waiver of such term, covenant or condition or any subsequent breach of the same or any other term, covenant or condition herein contained. The subsequent acceptance of rent
hereunder by Landlord shall not be deemed to be a waiver of any preceding breach by Tenant of any term, covenant or condition of this Lease, other than the failure of Tenant to pay the particular
rental so accepted, regardless of Landlord's knowledge of such preceding breach at the time of acceptance of such rent. No term, covenant or condition shall be deemed to have been waived by either
party unless such waiver is in writing and signed by the party making such waiver. 

        24.    No Accord and Satisfaction.    No payment by Tenant, or receipt by Landlord, or an amount which is less than
the full amount of rent and all other sums payable by Tenant hereunder at such time shall be deemed to be other than on account of (a) the earliest of such other sums due and payable, and
thereafter (b) the earliest Base Rent due and payable hereunder. No endorsement or statement on any check or any letter accompanying any payment of rent or such other sums shall be deemed an
accord and satisfaction. Landlord may accept any such check or payment without prejudice to 

32

 

Landlord's
right to receive payment of the balance of such rent and/or other sums or to Landlord's right to pursue any remedies to which Landlord may be entitled to recover such balance. 

        25.    Attorneys' Fees.    If any action or proceeding at law or in equity, or an arbitration proceeding (collectively
an "action") shall be brought to recover any rent under this Lease, or for or on account of any breach of or to enforce or interpret any of the terms, covenants or conditions of this Lease, or for the
recovery of possession of the Premises, the prevailing party shall be entitled to recover from the other party as a part of such action, or in a separate action brought for that purpose, its
reasonable attorneys' fees and costs and expenses incurred in connection with the prosecution or defense of such action (including any appeal and enforcement of any judgment or award), whether or not
the dispute is litigated or prosecuted to final judgment. "Prevailing party" within the meaning of this paragraph shall include, without limitation, a party who brings an action against the other
after the other is in breach or default, if such action is dismissed upon the other's payment of the sums allegedly due for performance of the covenants allegedly breached, or if the party commencing
such action obtains substantially the relief sought by it in such action, whether or not such action proceeds to a final judgment or determination. 

        26.    Surrender.    Tenant shall, upon expiration or sooner termination of this Lease, surrender the Premises to
Landlord in the same condition as existed on the Commencement Date (reasonable wear and tear, losses due to casualty and condemnation and Landlord's repair obligations excepted) with all holes in
walls repaired, all HVAC equipment in good operating order and in good repair (reasonable wear and tear, losses due to casualty and condemnation and Landlord's repair obligations excepted), and the
Premises in broom clean condition, all to the reasonable satisfaction of Landlord. In addition, prior to the expiration or earlier termination of this Lease Tenant shall: (a) upon Landlord's
request, remove all telephone and other cabling installed in the Building by Tenant; (b) remove from the Premises all Tenant's personal property and trade fixtures, and all property not so
removed shall be deemed abandoned by Tenant; and (c) remove all alterations that Landlord has elected to require Tenant to remove ; and Tenant shall repair any damage and perform any
restoration work caused by removal of any of the foregoing items. If such removal is not completed within the time periods required herein, Landlord shall have the right (but no obligation) to remove
the same and Tenant shall be liable to Landlord for costs of removal of any abandoned trade fixtures or equipment of Tenant, or of any alterations Tenant fails to remove if required by this Lease,
together with the cost of returning the Premises to the condition required by this Lease, and the transportation and storage costs of such items. All keys to the Premises or any part thereof shall be
surrendered to Landlord upon expiration or sooner termination of the lease term. 

Normal
wear and tear, for purposes of this provision, shall be construed to mean wear and tear caused to the Premises by the natural aging process that occurs in spite of application of good standards
for maintenance, repair and janitorial practices. It is not intended, nor shall it be construed, to include items of neglected or deferred maintenance which should have been attended to by Tenant in
accordance with the requirements of this Lease. 

        27.    Holding Over.    Unless Tenant exercises in a timely manner its option to extend the term, this Lease shall
terminate without further notice at the expiration of the initial lease term. Any holding over after the expiration shall be at one hundred seventy five percent (175%) of the monthly Base Rent for the
last month of the lease term for the first month and thereafter be at two hundred percent (200%) of the monthly Base Rent for the last month of the lease term, unless otherwise agreed in writing by
Landlord, and shall otherwise be on the terms and conditions herein specified insofar as applicable, unless otherwise mutually agreed in writing by the parties. Tenant shall indemnify, defend and hold
Landlord harmless from and against all claims, demands, actions, liabilities, damages, losses, costs and expenses, including reasonable attorneys' fees, arising or resulting directly or indirectly
from Tenant's failure to timely surrender the Premises, including, without limitation, (i) any rent payable by or any loss, cost, or damages paid by Landlord to any subsequent tenant of the
Premises, and 

33

 

(ii) Landlord's
damages as a result of a tenant terminating, a subsequent lease of the Premises by reason of such failure to timely surrender the Premises. Any holding over by Tenant after
expiration shall not constitute a renewal or extension of the lease term or give Tenant any rights in or to the Premises unless otherwise expressly provided in this Lease. 

        28.    Transfer of Premises by Landlord.    The term "Landlord" as used in this Lease, so far as the covenants or
obligations on the part of Landlord are concerned, shall be limited to mean and include only the owner at the time in question of the fee title to the Premises. In the event of any transfer of such
fee title, the Landlord herein named (and in case of any subsequent transfer or conveyance, the then grantor) shall after the date of such transfer or conveyance by automatically freed and relieved of
all liability with respect to performance of any covenants or obligations on the part of Landlord contained in this Lease thereafter to be performed. The covenants and obligations contained in this
Lease on the
part of Landlord shall, subject to the foregoing, be binding upon each Landlord hereunder only during his or its respective period of ownership except for any prior uncured defaults unless Tenant
failed to specify the default in an estoppel certificate requested for the benefit of such successor. 

        29.    General Provisions.    

        29.1.    Entire Agreement.    This instrument including the Exhibits attached hereto contains all of the agreements
and conditions made between the parties hereto and may not be modified orally or in any manner other than by an agreement in writing signed by all of the parties hereto or their respective successors
in interest. Any executed copy of this Lease shall be deemed an original for all purposes. 

        29.2.    Time.    Time is of the essence with respect to the performance of each and every provision of this Lease in
which time of performance is a factor. All references to days contained in this Lease shall be deemed to mean calendar days unless otherwise specifically stated. 

        29.3.    Captions.    The captions and headings of the numbered paragraphs of this Lease are inserted solely for the
convenience of the parties hereto, and are not a part of this Lease and shall have no effect upon the construction or interpretation of any part hereof. 

        29.4.    California Law; Construction.    This Lease shall be construed and interpreted in accordance with the laws of
the State of California. The language in all parts of this Lease shall in all cases be construed as a whole according to its fair meaning and not strictly for or against either Landlord or Tenant, and
without regard to which party prepared this Lease. 

        29.5.    Gender; Singular and Plural.    When required by the context of this Lease, the neuter includes the
masculine, the feminine, a partnership, a corporation or a joint venture, and the singular shall include the plural. 

        29.6.    Partial Invalidity.    If any provision of this Lease is held by a court of competent jurisdiction to be
invalid, void or unenforceable, the remainder of the provisions hereof shall nonetheless continue in full force and effect and shall in no way be affected, impaired, or invalidated thereby. 

        29.7.    No Warranties.    Any agreements, warranties or representations not expressly contained herein shall not bind
either Landlord or Tenant, and Landlord and Tenant expressly waive all claims for damages by reason of any statement, representation, warranty, promise or agreement, if any, not expressly contained in
this Lease. 

34

 

        29.8    Tenant Representations and Warranties.    Tenant hereby represents and warrants the following to Landlord: 

        (i)    Authority.    Tenant has all requisite power and authority to execute and deliver, and to perform all of its
obligations under, this Lease. 

        (ii)    Due Execution.    This Lease and all agreements, instruments and documents herein provided to be executed or
to be caused to be executed by Tenant are duly authorized, executed and delivered by Tenant. 

        (iii)    Consents; No Conflict.    Tenant has obtained all consents and permissions related to the transactions herein
contemplated and required under any covenant, agreement, encumbrance, or applicable law. Neither this Lease nor any agreement, document or instrument executed or to be executed in connection with the
same, nor anything provided in or contemplated by this Lease or any such other agreement, document or instrument, does now or shall hereafter breach, invalidate, cancel, make inoperative or interfere
with, or result in the acceleration or maturity of, any agreement, document, instrument, right or interest, to which Tenant is a party. 

        29.9.    Successors and Assigns.    The covenants and conditions herein contained, subject to the provisions as to
assignment, shall apply to and bind the heirs, executors, administrators, assigns, and any other person or entity succeeding lawfully, and pursuant to the provisions of this Lease, to the rights or
obligations of either of the parties hereto. 

        29.10.    Amendments.    This Lease may be amended by written agreement of amendment executed by both parties, but not
otherwise. 

        29.11.    Memorandum of Lease.    Neither party may record this Lease or a short form memorandum hereof without the
prior written consent of the other party. 

        29.12.    Merger.    The voluntary or other surrender of this Lease, or a mutual cancellation thereof, shall not work
an automatic merger, but shall, at the sole option of Landlord, either terminate all or any existing
subleases or subtenancies, or operate as an assignment to Landlord of any or all of such subleases or subtenancies. 

        29.13.    Real Estate Brokers.    Except as provided in this paragraph 29.13, each party represents that it has
not had any dealings with any real estate broker, finder or other person with respect to this Lease, and each party shall hold harmless the other party from all damages, expenses, and liabilities
resulting from any claims that may be asserted against the other party by any broker, finder or other person with whom the other party has dealt. Landlord and Tenant each has engaged Cornish &
Carey Commercial in connection with this transaction and Landlord shall be obligated to pay any and all commissions or fees which may be due said broker in connection with this transaction pursuant to
its agreement with said broker. The parties acknowledge that Cornish & Carey Commercial has disclosed that certain of its agents have ownership interests in Landlord. 

        29.14.    Limitation on Liability.    If Tenant obtains a money judgment against Landlord resulting from any default
or other claim arising under this Lease, such judgment shall be satisfied only out of Landlord's interest in the Premises or out of the rents, profits, income or insurance proceeds received by
Landlord with respect to its right, title and interest in the Premises. No other real, personal or mixed property of Landlord shall be subject to levy to satisfy any such judgment and Landlord shall
have no personal liability under this Lease. 

        29.15.    Quiet Enjoyment.    Landlord agrees to and shall in the commencement of this Lease place Tenant in quiet
possession of the Premises and shall secure it in the quiet possession thereof against all persons lawfully claiming the same during the lease term. 

35

 

        29.16.    Third Party Beneficiaries.    Except as otherwise expressly provided in this Lease, Landlord and Tenant do
not intend by any provision of this Lease to confer any right, remedy or benefit upon any third party, and no third party shall be entitled to enforce or otherwise shall acquire any right, remedy or
benefit by reason of any provision of this Lease. 

        29.17.    Interpretation.    Each party acknowledges and agrees that this Lease: (i) has been reviewed by it
and its counsel; (ii) is the product of negotiations between the parties, and (iii) shall not be deemed prepared or drafted by any one party. In the event of any dispute between the
parties concerning this Lease, the parties agree that any ambiguity in the language of the Lease is to not to be resolved against Landlord or Tenant, but shall be given a reasonable interpretation in
accordance with the plain meaning of the terms of this Lease and the intent of the parties as manifested hereby. 

        29.18.    Joint and Several Liability.    If more than one person or entity is identified as Tenant hereunder, the
obligations of each and all of them under this Lease shall be joint and several. 

        29.19.    Counterparts.    This Lease may be executed in multiple counterparts, each of which shall constitute an
original and all of which together shall constitute one agreement. 

        IN
WITNESS WHEREOF, Landlord and Tenant have executed this Lease on the dates specified below immediately adjacent to their respective signatures. Delivery of this Lease to Landlord,
duly executed by Tenant, constitutes an offer by Tenant to lease the Premises as herein set forth, and under no circumstances shall such delivery be deemed to create an option or reservation to lease
the Premises for the benefit of Tenant. This Lease shall only become effective and binding upon execution of this Lease by Landlord and delivery of a signed copy to Tenant. 

 

 

					
	 	 	 	 	"Landlord"
	

 	
 	

 	
 	
CALIFORNIA PACIFIC COMMERCIAL

CORPORATION, a California

corporation
	
Dated: Oct. 5, 2007	
 	
 By:	
 	
 /s/ DANIEL J. MCGANNEY, III

     Daniel J. McGanney, III

    President
	

 	
 	

 	
 	
"Tenant"
	

 	
 	

 	
 	
ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation
	
Dated: Oct. 5, 2007	
 	
 By:	
 	
 /s/ CHRISTINE GRAY-SMITH

     Its: Senior Vice President and

        Chief Financial Officer

 

36

 
EXHIBITS  

 

 

			
	Exhibit A	 	Description of Premises
	
Exhibit B	
 	
Work Letter Agreement
	
Exhibit C	
 	
Intentionally Omitted
	
Exhibit D	
 	
Permitted Uses

 

 37

 
PROPERTY DESCRIPTION 1020 EAST MEADOW CIRCLE 

PALO
ALTO, CALIFORNIA 

Parcel
Three, Parcel Map Recorded

April 22, 1974, Map Book 338 Page 4

Santa Clara County Records 

EXHIBIT "A"

 

  EXHIBIT "B"  

WORK LETTER AGREEMENT  

        This Work Letter Agreement (The "Agreement") supplements the Lease dated October 5, 2007, executed concurrently herewith by and
between CALIFORNIA PACIFIC COMMERCIAL CORPORATION ("Landlord") and ANACOR PHARMACEUTICALS, INC. ("Tenant"). 

        1.    General.    

        (a)   The
purpose of this Agreement is to set forth how the Tenant Improvements (as defined in Section 4 below) in the Premises are to be constructed, who will
undertake the construction of the Tenant Improvements, who will pay for the construction of the Tenant Improvements, and the procedure for preparation and Landlord's approval of the Final Plans (as
defined in Section 2 below). 

        (b)   Except
as defined in this Agreement to the contrary, all terms used in this Agreement shall have the same meaning given them in the Lease. When work, services, consents
or approvals are to be provided by or on behalf of Landlord, the term "Landlord" shall include Landlord's agents, contractors, employees and affiliates. 

        (c)   The
provisions of the Lease (including, without limitation, the provisions of paragraph 7), except to the extent inconsistent or inapplicable to this Agreement,
are incorporated into this Agreement. 

        (d)   The
Tenant Improvements shall be constructed pursuant to this Agreement by Tenant. Landlord shall provide the Tenant Improvement Allowance (as defined in
Section 5(a) below. 

        (e)   Tenant
shall make all Tenant Improvements to the Premises. All work done by or for Tenant on the Premises shall be in conformity with all applicable Laws. The term
"Laws" as used in this Lease shall mean all laws, statutes, codes, rules or regulations applicable to the Building. Tenant shall obtain at its expense all necessary permits for construction of the
Tenant Improvements. 

        2.    Preparation of Plans.    Tenant shall arrange for the preparation of the plans and specifications for its
proposed Tenant Improvements in accordance with this paragraph 2 by a licensed architect approved by Landlord, in the reasonable exercise of its discretion. 

        (a)    Preparation and Approval of Preliminary Plans.    

          (i)  Tenant
shall have prepared preliminary plans showing all of its proposed Tenant Improvements to the Premises (the "Preliminary Plans"). 

         (ii)  Tenant
shall submit to Landlord the Preliminary Plans for Landlord's review and approval. Within ten (10) days after Landlord receives the Preliminary Plans,
Landlord shall either approve or disapprove the Preliminary Plans; provided, however, that Landlord's approval shall not be unreasonably withheld, conditioned or delayed. In the event that Landlord
disapproves the Preliminary Plans, Landlord shall return the Preliminary Plans to Tenant together with the reasons for Landlord's disapproval (each, a "Design Problem"). Tenant shall make the changes
necessary in order to correct the Design Problems and shall return the Preliminary Plans to Landlord which Landlord shall approve or disapprove within five (5) days after Landlord receives the
revised Preliminary Plans. This procedure shall be repeated until the Preliminary Plans are finally approved by Landlord and written approval has been delivered to and received by Tenant. 

1

 

        (b)    Preparation and Approval of Working Drawings.    

          (i)  After
the Preliminary Plans are approved by Landlord, Tenant shall submit to Landlord drawings ("Working Drawings") which shall be compatible with the design,
construction and equipment of the Building, be capable of logical measurement and construction, contain all such information as may be required for the construction of the Tenant Improvements and the
permits for such Tenant Improvements and contain all plumbing locations, air conditioning system and duct work, special air conditioning requirements, reflected ceiling plans, and special security
systems, if applicable. 

         (ii)  Landlord
shall approve the Working Drawings within ten (10) days after receipt of same or designate by notice given within such time period to Tenant the
specific changes reasonably required to be made to the Working Drawings and shall return the Working Drawings to Tenant. Tenant shall make the changes necessary and shall return the Working Drawings
to Landlord, which Landlord shall approve or disapprove within five (5) days after Landlord receives the revised Working Drawings. This procedure shall be repeated until all of the Working
Drawings are finally approved by Landlord and written approval has been delivered to and received by Tenant. The Working Drawing so approved are referred to as the "Final Plans". 

        (iii)  Tenant
shall verify, in the field, the dimensions and conditions as shown on the relevant portions of any Building plans provided by Landlord to Tenant. Tenant shall
be solely responsible for the same and Landlord shall have no responsibility in connection therewith. 

        (c)    No Liability for Approval.    Landlord's review and approval of the Preliminary Plans, Working Drawings, the
Final Plans(collectively, the "Construction Drawings") or other documents shall be for its sole purpose and not constitute any representation or warranty by or on behalf of Landlord as to the
adequacy, efficiency, suitability, fitness or desirability of any space layout or improvements or otherwise constitute assumption by Landlord of any responsibility for the accuracy or sufficiency
thereof, or to be interpreted as a statement of compliance with code requirements. Accordingly, notwithstanding that any Construction Drawings are reviewed by Landlord or its architect, engineers and
consultants, and notwithstanding any advice or assistance which may be rendered to Tenant by Landlord or Landlord's architect, engineers, and consultants, Landlord shall have no liability whatsoever
in connection therewith and shall not be responsible for any omissions or errors contained in the Construction Drawings. 

        3.    Contractor.    Tenant shall select a contractor ("Contractor") subject to the approval of Landlord, which
approval shall not be unreasonably withheld, delayed or conditioned. Tenant may have Landlord approve three (3) or more contractors prior to any competitive bidding. Work involving sprinkler,
plumbing, mechanical, electrical power, lighting or fire safety systems of the Building shall be performed only by subcontractors approved by Landlord, which approval shall not be unreasonably
withheld, delayed or conditioned. 

        4.    Tenant Improvements.    The term "Tenant Improvements" shall mean all improvements shown in the Final Plans. The
Tenant Improvements shall be constructed in accordance with the Final Plans. No material changes shall be made to the Final Plans without the prior approval of Landlord in accordance with
paragraph 6 below and obtaining all requisite governmental approvals for such changes. All Tenant's materials, work, installations and decorations of any nature brought upon or installed in the
Premises before or after the Commencement Date shall be at Tenant's risk, and neither Landlord nor any party acting on Landlord's behalf shall be responsible for any damage thereto or loss or
destruction thereof except to the extent arising from the gross negligence or willful misconduct of Landlord or any party acting on Landlord's behalf, except as otherwise provided in the Lease. Except
as provided in paragraph 5 below, all cost of construction shall be borne by Tenant. Upon completion 

2

 

of
the Tenant Improvements, Tenant shall deliver to Landlord "as-built" plans and specifications therefor. 

        5.    Tenant Improvement Allowance.    

        (a)    Amount.    Landlord will pay to Tenant an amount equal to Three Hundred Sixty Nine Thousand Six Hundred Dollars
($369,600) ("Tenant Improvement Allowance") as reimbursement for the costs of the construction of the Tenant Improvements, including any amount paid for design, space planning, consultants,
construction drawings, laboratory construction (including the cost of purchase and installation of fume hoods), IT/wiring costs, cosmetic upgrades, office renovation and related plumbing, HVAC and
electrical upgrades. No portion of the Tenant Improvement Allowance may be used for furnishings, trade fixtures, or other items or equipment (such as laboratory benches) that are that are removable by
Tenant upon the expiration of the term of the Lease. 

        (b)    Disbursement.    The Tenant Improvement Allowance shall be paid to Tenant upon substantial completion of the
Tenant Improvements. As a condition precedent to the payment of the Tenant Improvement Allowance, Tenant shall have (i)substantially completed the Tenant Improvements and delivered to Landlord
(A) a certification from Tenant's architect that the Tenant Improvements have been completed substantially in accordance with the Final Plans and (B) a copy of the occupancy permit
issued by the City of Palo Alto; (ii)provided Landlord with copies of paid invoices for the entire cost of the Tenant Improvements; (iii) provided Landlord with appropriate unconditional
mechanic's lien releases with respect to all of the work performed in the construction of the Tenant Improvements; and (iv) have provided evidence reasonably satisfactory to Landlord that the
statutory time period for filing liens has expired and that no mechanics or other liens have been filed in connection with the construction of the Tenant Improvements. 

        6.    Change Orders.    In the event that Tenant requests any changes to the Final Plans, Landlord shall not
unreasonably withhold, delay or condition its consent to any such changes. 

        7.    No Fee to Landlord.    Landlord shall receive no fee for supervision, administration, profit, overhead or
general conditions in connection with the Tenant Improvements. 

        8.    Bonding.    Landlord shall have the right to require the Contractor to obtain a payment and performance bond in
form reasonably acceptable to Landlord in the event that the Contractor is not on the approved list attached hereto as Exhibit A. 

        IN
WITNESS WHEREOF, the parties have entered into this Agreement as of the date first written above. 

 

 

					
	LANDLORD:	 	 
	

CALIFORNIA PACIFIC COMMERCIAL CORPORATION	
 	

 
	
By:	
 	
 /s/ DANIEL MCGANNEY

     President	
 	

 
	

TENANT:	
 	

 
	

ANACOR PHARMACEUTICALS, INC.	
 	

 
	
By:	
 	
 /s/ CHRISTINE GRAY-SMITH

 	
 	

 
	 	 	    Senior Vice President and Chief Financial Officer

 

 3

   Exhibit "D"  

 Reportable Uses  

        Approved "Reportable Uses" are those for which the following permits are required: 

 

 

							
	 
	 	Permit or License 	 	Administering Agency 	 	Description 
	1)	 	Hazardous Material Use Permit	 	City of Palo Alto	 	Permits the storage, handle, and use of hazardous materials.
	
2)	
 	
Wastewater discharge permit	
 	
City of Palo Alto	
 	
Allows discharge of industrial wastewater for treatment at the local PTOW.
	
3)	
 	
Medical Waste Permit	
 	
Santa Clara County	
 	
Permit the shipment for proper controlled disposal of biowaste material.
	
4)	
 	
Air Emissions Permit	
 	
Bay Air Quality Control District	
 	
Permits the use of an emergency generator.
	
5)	
 	
Radiological Use License	
 	
Cal Radiological Health Branch	
 	
Allows the use of radioisotopes in select lab processes.
	
6)	
 	
EPA Id Number	
 	
Environmental Protection Agency	
 	
Allows hazardous waste shipment for proper disposal.
	
7)	
 	
Control Substance Permit	
 	
Drug Enforcement Agency	
 	
Permits the possession of select narcotics for research purposes.Exhibit 10.27  

LOAN AND SECURITY AGREEMENT  

        THIS LOAN AND SECURITY AGREEMENT NO. 5251 (this
"Agreement") is entered into as of June 30, 2006, by and between LIGHTHOUSE CAPITAL PARTNERS V,
L.P. ("Lender") and ANACOR PHARMACEUTICALS, INC., a Delaware corporation
("Borrower") and sets forth the terms and conditions upon which Lender will lend and Borrower will repay money. In consideration of the mutual covenants
herein contained, the parties agree as follows: 

1.    DEFINITIONS AND CONSTRUCTION  

        1.1    Definitions.    Initially capitalized terms used and not
otherwise defined herein are defined in the California Uniform Commercial Code ("UCC"). 

        "ACH" means the Automated Clearing House electronic funds transfer system. 

        "Advance" means a Loan advanced by Lender to Borrower hereunder. 

        "Basic Rate" means a variable per annum rate of interest equal to the Index plus the
Interest Margin which shall be subject to adjustment as provided in the Loan Agreement. On and after the Loan Commencement Date the Basic Rate shall be fixed and not subject to any further
adjustments. 

        "Borrower's Books" means all of Borrower's books and records, including records concerning Collateral, Borrower's assets, liabilities,
business operations or financial condition, on any media, and the equipment containing such information. 

        "Collateral" means: (i) all property in which Lender now has or hereafter obtains a
security interest or which is listed on any UCC-1 naming Borrower as Debtor in any capacity and Lender or an affiliate of Lender as Secured Party including  Exhibit A attached hereto; and
(ii) all products and proceeds of the foregoing, including
proceeds of insurance and proceeds of proceeds. 

        "Commitment" means $8,000,000, such Commitment availability subject to Borrower closing a Preferred Stock Financing and the issuance of a
Warrant to Lender as set forth in Section 6.8 hereof. 

        "Commitment Fee" means $10,000. 

        "Commitment Termination Date" means the earliest to occur of (i)
(a) October 1, 2006, if Borrower has not drawn at least $2,500,000 by such date, or (b) April 1, 2007; (ii) any Default or
Event of Default, (iii) for any Advances, the date at which any 2 of the persons currently serving as either Chief Executive Officer, Chief Financial
Officer or a Senior Vice-President of the Borrower cease to be involved in the management of Borrower; or (iv) the date on which any 2 of Rho Venture Partners; Venrock Partners;
Aberdare Ventures or Care Capital cease to have a representative on Borrower's Board of Directors. 

        "Control Agreement" means an agreement substantially in the form of Exhibit I or
otherwise acceptable to Lender. 

        "Default" means any event that with the passing of time or the giving of notice or both would become an Event of Default. 

        "Default Rate" means the lesser of 18% per annum or the highest rate permitted by applicable law. 

        "Disclosure Schedule" means the schedule attached as Schedule 1 hereto. 

        "Event of Default" is defined in Section 8. 

        "Funding Date" means any date on which an Advance is made to or on account of Borrower hereunder. 

1

 

        "Indebtedness" means (i) all indebtedness for borrowed money or the deferred purchase of
property or services, (ii) all obligations evidenced by notes, bonds, debentures or similar instruments,  (iii) all capital lease obligations, and
(iv) all contingent obligations, including guaranties and
obligations of reimbursement or respecting letters of credit. 

        "Incumbency Certificate" means the document in the form of Exhibit E. 

        "Index" means the prevailing variable Prime Rate of annual interest as quoted from time to time in the western edition of the Wall Street
Journal. 

        "Interest Margin" means 2% per annum. 

        "Lender's Expenses" means all reasonable costs or expenses (including reasonable attorneys' fees and expenses) incurred in connection with
the preparation, negotiation, modification, administration, or enforcement of the Loan or Loan Documents, or the exercise or preservation of any rights or remedies by Lender, whether or not suit is
brought; provided, however, that Lender's Expenses for the preparation and negotiation of the initial set of Loan Documents shall not exceed $10,000.
Lender will apply deposits received before the date hereof, if any, towards Lender's Expenses. 

        "Lien" means any lien, security interest, pledge, bailment, lease, mortgage, hypothecation, conditional sales and title retention
agreement, charge, claim, or other encumbrance. 

        "Loan" means all of the Advances, however evidenced, and all other amounts due or to become due hereunder. 

        "Loan Commencement Date" means January 1, 2008. 

        "Loan Documents" means, collectively, this Agreement, the Warrant, the Notes and all other documents, instruments and agreements entered
into between Borrower and Lender in connection with the Loan, all as amended or extended from time to time. 

        "Negative Pledge Agreement" means an agreement in the form of Exhibit H. 

        "Note" means a Secured Promissory Note in the form of Exhibit B. 

        "Notice of Borrowing" means the form attached as Exhibit D. 

        "Obligations" means all Loans, debt, principal, interest, fees, charges, Lender's Expenses and other amounts, obligations, covenants, and
duties owing by Borrower to Lender of any kind or description (whether pursuant to the Loan Documents or otherwise (with the exception of the Warrant), and whether or not for the payment of money),
whether direct or indirect, absolute or contingent, due or to become due, now existing or hereafter arising, and including any of the same obtained by Lender by assignment or otherwise, and all
amounts Borrower is required to pay or reimburse by the Loan Documents, by law, or otherwise. 

        "Permitted Indebtedness" means: (i) the Loan;  (ii) unsecured trade debt incurred in the ordinary course of Borrower's
business; (iii) Indebtedness
secured by clause (ii) of Permitted Liens; and (iv)Subordinated Debt. 

        "Permitted Liens" means: (i) Liens in favor of Lender;  (ii) Liens disclosed in the Disclosure Schedule; (iii) Liens for taxes, fees, assessments or other
governmental charges or levies not delinquent or being contested in good faith by appropriate proceedings, that do not jeopardize Lender's interest in any Collateral; and  (iv) Liens to secure payment of
worker's compensation, employment insurance, old age pensions or other social security obligations of Borrower on which
Borrower is current and are in the
ordinary course of its business; provided none of the same diminish or impair Lender's rights and remedies respecting the Collateral. 

2

 

        "Preferred Stock Financing" means Borrower's Series D Preferred Stock financing with gross proceeds to Borrower of at least
$5,000,000 and at a pre-money valuation not to exceed $86,000,000. 

        "Regulated Substance" means any substance, material or waste the use, generation, handling, storage, treatment or disposal of which is
regulated by any local or state government authority, including any of the same designated by any authority as hazardous, genetic, cloning, fetal, or embryonic. 

        "Responsible Officer" means each person as authorized by the board of directors of Borrower as set forth on the Incumbency Certificate. 

        "Subordinated Debt" means Indebtedness of Borrower, lead by its existing investors in an amount not to exceed $5,000,000 that is
subordinated in both security and right of payment to the Obligations on terms and conditions satisfactory to Lender as evidenced by a subordination agreement between Lender and the provider(s) of
such Subordinated Debt. 

        "Term" means the period from and after the date hereof until the full, final and indefeasible payment and performance of all Obligations. 

        "Warrant" means the Warrant in favor of Lender and its affiliates to purchase securities of Borrower substantially in the form of  Exhibit C to be issued in
accordance with Section 6.8 hereof.
 

        1.2    Interpretation.    References to "Articles," "Sections,"
"Exhibits," and "Schedules" are to articles, sections, exhibits and schedules herein and hereto unless otherwise indicated. "Hereof," "herein" and "hereunder" refer to this Agreement as a whole.
"Including" is not limiting. All accounting and financial computations shall be computed in accordance with generally accepted accounting principles consistently applied
("GAAP"). "Or" is not necessarily exclusive. All interest computation shall be based on a 360-day year and actual days elapsed. 

2.    THE LOANS  

        2.1    Commitment.    Subject to the terms hereof, Lender will make
Advances to Borrower up to the principal amount of the Commitment, on or before the Commitment Termination Date. Notwithstanding anything in the Loan Documents to the contrary, Lender's obligation to
make any Advances or to lend the undisbursed portion of the Commitment shall terminate on the Commitment Termination Date. Repaid principal of the Advances may not be re-borrowed. 

        2.2    The Advances.    A Note setting forth the specific terms of
repayment will evidence each Advance. No Advance will be made for less than $500,000, unless less than $500,000 remains available under the Commitment for borrowing. Absence of a Note evidencing any
portion of the Loan shall not impair Borrower's obligation to repay it to Lender. 

        2.3    Terms of Payment, Repayment.    

        (a)    Repayment.    Borrower shall repay the principal and pay
interest on each Advance on the terms set forth in the applicable Note. Amounts not paid when due hereunder or under the Note shall bear interest at the Default Rate. If a court of competent
jurisdiction determines that Lender has received payments that, if interest, would exceed the maximum lawfully permitted, Lender will instead apply such money to fees and expenses and then to early
prepayment of principal. 

        (b)    ACH.    All payments due to Lender must be, at Lender's option,
paid to Lender in cash or through ACH. Borrower shall execute and deliver the ACH Authorization Form substantially in the form of Exhibit G. If
the ACH payment arrangement is terminated for any reason, Borrower shall make all payments due to Lender at Lender's address specified in  Section 11. 

3

 

        (c)    Default Rate.    While an Event of Default has occurred and is
continuing, interest on the Loan shall be increased to the Default Rate. Lender's failure to charge or accrue interest at the Default Rate during the existence of a Default shall not be deemed a
waiver by Lender of its right or claim thereto. 

        (d)    Date.    Whenever any payment due under the Loan Documents is
due on a day other than a business day, such payment shall be made on the next succeeding business day, and such extension of time shall be included in the computation of interest or fees, as the case
may be. 

        2.4    Fees.    Borrower shall pay to Lender the following: 

        (a)    Commitment Fee.    The Commitment Fee, which has been
previously paid by Borrower, and shall be applied by Lender to Lender's Expenses and other Obligations. 

        (b)    Late Fee.    On demand, a late charge on any sums due hereunder
that are not paid when due, in an amount equal to 2% of the past due amount, payable on demand. 

        (c)    Lender's Expenses.    When requested, all Lender's Expenses.
Lender's Expenses not paid when due shall bear interest as principal at the Default Rate. 

3.    CONDITIONS OF ADVANCES; PROCEDURE FOR REQUESTING ADVANCES  

        3.1    Conditions Precedent to any and all Advances.    The obligation
of Lender to make any Advances is subject to each and every of the following conditions precedent in form and substance satisfactory to Lender in its sole discretion:  (i) this Agreement, a Note
evidencing the Advance, the Warrant, and all other UCC financing statements, and other documents required or as
specified herein have been duly authorized, executed and delivered; (ii) no Default or Event of Default has occurred and is continuing;  (iii) delivery of a
Notice of Borrowing with respect to the proposed Advance; (iv) Lender's security
interests in the Collateral are valid and first priority, except for Permitted Liens; (v) Borrower shall have opened a new account
#14994-19632 with Bank of America and Lender shall have received a signed Control Agreement for such account and any other new accounts with said institution; and  (vi) all such other items as Lender may
reasonably deem necessary or appropriate have been delivered or satisfied. The extension of an Advance prior to
the receipt by Lender of any of the foregoing shall not constitute a waiver by Lender of Borrower's obligation to deliver such item. 

        3.2    Procedure for Making Advances.    For any Advance, Borrower
shall provide Lender an irrevocable Notice of Borrowing at least 10 business days prior to the desired Funding Date and Lender shall only be required to make Advances hereunder based upon written
requests which comply with the terms and exhibits of this Loan Agreement (as the same may be amended from time to time), and which are
submitted and signed by a Responsible Officer. Borrower shall execute and deliver to Lender a Note and such other documents and instruments as Lender may reasonably require for each Advance made. 

4.    CREATION OF SECURITY INTEREST  

        4.1    Grant of Security Interest.    Borrower grants to Lender a
valid, first priority, continuing security interest in all present and future Collateral in order to secure prompt, full, faithful and timely payment and performance of all Obligations. 

        4.2    Inspections.    While any Obligations remain outstanding,
Lender shall have the right upon reasonable prior notice to inspect Borrower's Books, including computer files, and to make copies, and to test, inspect and appraise the Collateral, in order to verify
any matter relating to Borrower or the Collateral. 

4

 

        4.3    Authorization to File Financing Statements.    Borrower
irrevocably authorizes Lender at any time and from time to time to file in any jurisdiction any financing statements and amendments that: (i) name
Collateral as collateral thereunder, regardless of whether any particular Collateral falls within the scope of the UCC; (ii) contain any other
information required by the UCC for sufficiency or filing office acceptance, including organization identification numbers; and (iii) contain such
language as Lender determines helpful in protecting or preserving rights against third parties. Borrower ratifies any such filings made prior to the date hereof. 

5.    REPRESENTATIONS AND WARRANTIES  

        Borrower represents, warrants and covenants as follows: 

        5.1    Due Organization and Qualification.    Borrower is a
corporation duly formed, existing and in good standing under the laws of its state of incorporation and qualified and licensed to do business in, and is in good standing in, any state in which the
conduct of its business or its ownership of property requires
that it be so qualified or in which the Collateral is located, except for states other than California and Delaware as to which any failure so to qualify would not reasonably be expected to have a
material adverse effect on Borrower or any of the Collateral. 

        5.2    Authority.    Borrower has all corporate power and authority,
and has taken all actions, and has obtained all third party consents necessary to execute, deliver, and perform the Loan Documents. 

        5.3    Disclosure Schedule.    All information on the Disclosure
Schedule is true, correct and complete. 

        5.4    Authorization; Enforceability.    The execution and delivery
hereof, the granting of the security interest in the Collateral, the incurring of the Obligations, the execution and delivery of all Loan Documents and the consummation of the transactions herein and
therein contemplated have been duly authorized by all necessary action by Borrower. The Loan Documents constitute legal, valid and binding obligations of Borrower, enforceable in accordance with their
terms, except as enforceability may be limited by bankruptcy or similar laws relating to enforcement of creditors' rights generally. 

        5.5    Name and Location.    Borrower has not done business under any
name other than that specified on the signature page hereof or as set forth on the Disclosure Schedule. The chief executive office, principal place of business, and the place where Borrower maintains
its records concerning the Collateral is set forth in Section 11. The Collateral is presently located at the address(es) set forth in  Section 11
and on the Disclosure Schedule. 

        5.6    Litigation.    All actions or proceedings pending or threatened
by or against Borrower before any court or administrative agency are set forth on the Disclosure Schedule.

        5.7    Financial Statements.    All financial statements fairly
represent the financial condition of the Borrower. All statements respecting Collateral that have been or may hereafter be delivered by Borrower to Lender are true, complete and correct in all
material respects for the periods indicated. 

        5.8    Solvency.    Borrower is solvent and able to pay its debts
(including trade debts) as they come due. 

        5.9    Taxes.    Borrower has filed and will file all required tax
returns, and has paid and will pay all taxes it owes other than where the failure to comply would not reasonably be expected to have an adverse effect on Borrower. 

        5.10    Rights; Title to Assets.    Borrower possesses and owns all
necessary assets, rights, trademarks, trade names, copyrights, patents, patent rights, franchises and licenses which it needs to conduct its business as now operated or proposed to be operated.
Borrower has good title to its assets, free and clear of any Liens, except for Permitted Liens. 

5

 

        5.11    Full Disclosure.    No written representation, warranty or
other statement made by Borrower in any Loan Document, certificate or statement furnished to Lender contains any untrue statement of a material fact or omits to state a material fact necessary in
order to make the statements contained in such certificates or statements not misleading. 

        5.12    Regulated Substances.    To its knowledge, Borrower complies
and will comply with all laws respecting Regulated Substances in all material respects. 

        5.13    Reaffirmation.    Each Notice of Borrowing will constitute  (i) a warranty and representation
in favor of Lender that there does not exist any Default and (ii)
subject to any amended Disclosure Schedule delivered to Lender or any other written disclosure required to be sent to Lender pursuant to the terms hereof, a reaffirmation as of the date thereof of all
of the representations and warranties contained in this Agreement and the Loan Documents, provided, however, and notwithstanding any provision in this
Agreement to the contrary, if any such amended Disclosure Schedule contains any matter which could reasonably be expected to have a material adverse effect on Borrower or the Collateral, Lender's
obligation to make Advances to Borrower hereunder shall be suspended during the pendency of any such material adverse effect condition. 

6.    AFFIRMATIVE COVENANTS  

        Borrower covenants and agrees that it shall do all of the following: 

        6.1    Good Standing and Compliance.    Borrower shall maintain all
governmental licenses, rights and agreements necessary for its operations or business and comply in all material respects with all statutes, laws, ordinances and government rules and regulations to
which it is subject. 

        6.2    Financial Statements, Reports, Certificates.    Borrower shall
deliver to Lender: (i) as soon as prepared, and no later than 30 days after the end of each calendar month, a balance sheet, income statement and
cash flow statement covering Borrower's operations during such period; (ii) as soon as prepared, but no later than 180 days after the end of the
fiscal year, audited financial statements prepared in accordance with GAAP, together with an opinion that such financial statements fairly present Borrower's financial condition by an independent
public accounting firm reasonably acceptable to Lender; (iii)promptly upon notice thereof, a report of any legal or administrative action pending or
threatened against Borrower which is likely to result in liability to Borrower in excess of $50,000; and (iv) such other financial information as Lender
may reasonably request from time to time. Financial statements delivered pursuant to subsections (i) and  (ii) above shall be accompanied by a certificate
signed by a Responsible Officer (each an "Officer's
Certificate") in the form of Exhibit F.  

        6.3    Notice of Defaults.    Reasonably
promptly after discovering any Default or Event of Default, deliver an Officer's Certificate setting forth the facts relating to or giving rise thereto, and the Borrower's proposed action with respect
thereto. 

        6.4    Use; Maintenance.    Borrower, at its expense, shall  (i) maintain the Collateral in good
condition, reasonable wear and tear excepted, and will comply in all material respects with all laws, rules and
regulations regarding use and operation of the Collateral and (ii) repair or replace any lost or damaged Collateral, other than Collateral that is
obsolete or worthless at the time of loss or damage or that Borrower determines in good faith is not necessary or useful in the conduct of its business. 

        6.5    Insurance.    Borrower, at its own expense, shall maintain
insurance in amounts and coverages reasonably satisfactory to Lender. Each insurance policy shall: (i) name Lender loss payee or additional insured, as
appropriate, (ii)provide for insurer's waiver of its right of subrogation against Lender and Borrower,  (iii) provide that such insurance shall not be
invalidated by any action of, or breach of warranty by, Borrower and waive set-off,
counterclaim or offset against Lender, (iv) be primary without a right of contribution of Lender's insurance, if any, or any obligation on the part of
Lender to pay 

6

 

premiums
of Borrower, and (v) require the insurer to give Lender at least 30 days prior written notice of cancellation. Borrower shall furnish
all certificates of insurance required by Lender. 

        6.6    Loss Proceeds.    So long as no Event of Default has occurred
and is continuing, any proceeds of insurance on or condemnation of Collateral shall, at Borrower's election and so long as Lender's security interest in such proceeds remains first priority, be used
either to repair or replace such Collateral or otherwise applied to the purchase or acquisition of property useful to Borrower's business. 

        6.7    Further Assurances.    At any time and from time to time,
Borrower shall execute and deliver such further instruments and take such further action as Lender may reasonably request to effect the intent
and purposes hereof, to perfect and continue perfected and of first priority Lender's security interests in the Collateral, and to effect and maintain ACH payment arrangements. 

        6.8    Preferred Stock Financing.    Borrower shall provide Lender
with evidence reasonably satisfactory to Lender of the closing of the Preferred Stock Financing. Within 10 days of the closing of the Preferred Stock Financing, Borrower shall issue Lender a
Warrant to purchase such number of shares of preferred stock as sold in such Preferred Stock Financing initially equal to $260,000 divided by the price per share paid by investors in such Preferred
Stock Financing. The purchase price per share of preferred stock purchasable under the Warrant shall be the price per share paid by the investors in the Preferred Stock Financing. The number of shares
purchasable under the Warrant shall be subject to increase based on Advances made under the Commitment as set forth in the Warrant. 

7.    NEGATIVE COVENANTS  

        Borrower will not do any of the following: 

        7.1    Location of Collateral.    Change its chief executive office or
principal place of business or remove, except in the ordinary course of Borrower's business, the Collateral or Borrower's Books from the premises listed in  Section 11 without giving 30 days
prior written notice to Lender. 

        7.2    Extraordinary Transactions.    Enter into any transaction not
in the ordinary course of Borrower's business as presently conducted or as proposed to be conducted in Borrower's business plan, including the sale, lease, license or other disposition of its assets,
other than (i) sales of inventory in the ordinary course of Borrower's business; and (ii) licenses of
Borrower's intellectual property assets (a) entered into in the ordinary course of Borrower's business as presently conducted or (b) as proposed to be conducted in Borrower's business
plan, including, for example, licenses of intellectual property rights related to AN0128 or AN2690. The parties hereto agree that strategic partnerships that do not involve a transfer of a material
portion of Borrower's assets shall be deemed to be in the "ordinary course of business" for purposes of this Agreement. 

        7.3    Restructure.    Make any material change in Borrower's
financial structure or business operations (other than through the sale of preferred stock to equity investors); or suspend operation of Borrower's business. 

        7.4    Liens.    Create, incur, assume or suffer to exist any Lien of
any kind with respect to any of its property, whether now owned or hereafter acquired, except for Permitted Liens. 

        7.5    Indebtedness.    Create, incur, assume or suffer to exist any
Indebtedness, other than Permitted Indebtedness. 

        7.6    Distributions.    Pay any dividends or distributions, or
redeem or purchase, any capital stock, except for repurchases of capital stock from departing employees or directors, under repurchase agreements approved by the Borrower's Board of Directors. 

        7.7    Transactions with Affiliates.    Directly or indirectly enter
into any transaction with any affiliate which is on terms less favorable to Borrower than would be obtained in an arm's length 

7

 

transaction
with a non-affiliated entity; provided, any such transaction shall not be a breach of this  Section 7.7 if approved by a disinterested majority of the
Borrower's Board of Directors. 

        7.8    Compliance.    (i) Become an "investment company" under the
Investment Company Act of 1940 or extend credit to purchase or carry margin stock; (ii) fail to meet the minimum funding requirements of ERISA;  (iii)
permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; (iv) fail to
comply with the Federal Fair Labor Standards Act; or (v) violate any other material law or material regulation, in each case unless such event, failure
or violation would not have a material adverse effect on Borrower or the Collateral. 

        7.9    UCC Effectiveness.    Change its name, jurisdiction of
organization, or take any other action that could render Lender's financing statements misleading under the UCC, without giving Lender 30 days advance written notice. 

        7.10    Deposit and Securities Accounts.    Maintain any deposit
accounts or accounts holding securities owned by Borrower except accounts in which Lender has obtained a perfected first priority security interest. Notwithstanding the foregoing, Lender shall not
have a perfected security interest in Borrower's accounts #0117120009 and # W89-080560 with Bank of America and Bank of America Securities, respectively, listed on the Disclosure Schedule,  provided, however, Borrower shall close such accounts within 120 days from the date hereof. 

8.    EVENTS OF DEFAULT  

        Any one or more of the following shall constitute an Event of Default by Borrower hereunder: 

        8.1    Payment.    Borrower fails to pay when due and payable in
accordance with the Loan Documents any portion of the Obligations, or cancels an ACH payment or transfer Lender has initiated in conformity with the terms hereof provided,
however, that an Event of Default shall not occur on account of a failure to pay due solely to an administrative or operational error if Borrower had the funds to make the
payment when due and makes the payment the business day following Borrower's knowledge of such failure to pay. 

        8.2    Certain Covenant Defaults.    Borrower fails to perform any
obligation under Section 6.5 or 6.6, or violates any of the covenants contained in  Section 7.

        8.3    Other Covenant Defaults.    Borrower fails or neglects to
perform, keep, or observe any other term, provision, condition, covenant, or agreement contained in this Agreement, in any of the other Loan Documents, or in any other present or future agreement
between Borrower and Lender and has failed to cure such failure within 15 days after its occurrence. 

        8.4    Attachment.    Any material portion of Borrower's assets is
attached, seized, subjected to a government levy, lien, writ or distress warrant, or comes into the possession of any trustee or receiver and the same is not returned, removed, waived, stayed,
discharged or rescinded within 10 days. 

        8.5    Other Agreements.    There is a default in any agreement to
which Borrower is a party resulting in a right by a third party, whether or not exercised, to accelerate the maturity of any Indebtedness, in an amount greater than $100,000;  provided that in the event
Borrower in good faith disputes whether a default has occurred under such agreement and has adequate reserves, there shall
not be an Event of Default under this Section until the earlier of actual exercise by the third party of such right to accelerate or 30 days after such default. 

        8.6    Judgments.    One or more judgments for an aggregate of at
least $100,000 is rendered against Borrower and remains unsatisfied and unstayed for more than 30 days. 

8

 

        8.7    Injunction.    Borrower is enjoined, restrained, or in any way
prevented by court order from continuing to conduct any material part of its business affairs, or if a judgment or other claim becomes a Lien upon any material portion of Borrower's assets. 

        8.8    Misrepresentation.    Any representation, statement, or report
made to Lender by Borrower was false or misleading when made in any material respect. 

        8.9    Enforceability.    Lender's ability to enforce its rights
against Borrower or any Collateral is impaired in any material respect, or Borrower asserts that any Loan Document is not a legal, valid and binding obligation of Borrower enforceable in accordance
with its terms. 

        8.10    Involuntary Bankruptcy.    An involuntary bankruptcy case
remains undismissed or unstayed for 30 days or, if earlier, an order granting the relief sought is entered. 

        8.11    Voluntary Bankruptcy or Insolvency.    Borrower commences a
voluntary case under applicable bankruptcy or insolvency law, consents to the entry of an order for relief in an involuntary case under any such law, or consents or is subject to the appointment of or
taking possession by a receiver, liquidator, assignee, trustee, custodian or other similar official of Borrower or any substantial part of its property, or makes an assignment for the benefit of
creditors, or fails generally or admits in writing to its inability to pay its debts as they become due, or takes any corporate action in furtherance of any of the foregoing. 

        8.12    Merger, Sale or Change of Control.    The occurrence of  (i) a merger of Borrower with another
entity (whether or not the Borrower is the "surviving entity") whereby the shareholders of Borrower immediately
prior to such merger own less than 50% of the outstanding voting securities of Borrower immediately after such merger; (ii) the sale (in one or a series
of related transactions) of all or substantially all of Borrower's assets; or (iii) any transaction (or series of related transactions) other than a
transaction that is a bona fide equity financing with the primary purpose of raising capital for Borrower, whereby the shareholders of Borrower immediately prior to such transaction(s) own less than
50% of the outstanding voting securities of Borrower immediately after such transaction(s), and in each case such acquirer or resulting entity (including, Borrower, if Borrower is the resulting or
surviving entity) fails to either: (a) pay off the Obligations in cash at the closing of the acquisition, merger or sale or  (b) provide an unconditional,
unlimited guaranty or reaffirmation of the Obligations in form and substance reasonably satisfactory to Lender and is of a
credit quality acceptable to Lender. 

9.    LENDER'S RIGHTS AND REMEDIES  

        9.1    Rights and Remedies.    Upon the occurrence and continuance of
any Event of Default, Lender may, at its election, without notice of election and without demand, do any one or more of the following, all of which are authorized by Borrower:  (i) accelerate and declare
the Loan and all Obligations immediately due and payable; (ii) make such
payments and do such acts as Lender considers necessary or reasonable to protect its security interest in the Collateral, with such amounts becoming Obligations bearing interest at the Default Rate;  (iii) exercise any and all other rights and remedies available under the UCC or otherwise; (iv) require
Borrower to assemble the Collateral at such places as Lender may designate; (v) enter premises where any Collateral is located, take, maintain
possession of, or render unusable the Collateral or any part of it; (vi) without notice to Borrower, set off and recoup against any portion of the
Obligations; (vii) ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell the Collateral, in connection
with which Borrower hereby grants Lender a license to use without charge Borrower's premises, labels, name, trademarks, and other property necessary to complete, advertise, and sell any Collateral;
and (viii) sell the Collateral at one or more public or private sales. 

        9.2    Power of Attorney in Respect of the Collateral.    Borrower
hereby irrevocably appoints Lender (which appointment is coupled with an interest) its true and lawful attorney in fact with full 

9

 

power
of substitution, for it and in its name to, upon and during the continuation of an Event of Default: (i) ask, demand, collect, receive, sue for,
compound and give acquittance for any and all Collateral with full power to settle, adjust or compromise any claim, (ii) receive payment of and endorse
the name of Borrower on any items of Collateral, (iii) make all demands, consents and waivers, or take any other action with respect to, the Collateral,  (iv) file any claim or take any other action, in Lender's or Borrower's name, which Lender may reasonably deem appropriate to protect its rights in the
Collateral, or (v) otherwise act with respect to the Collateral as though Lender were its outright owner. 

        9.3    Charges.    If Borrower fails to pay any amounts required
hereunder to be paid by Borrower to any third party, Lender may at its option pay any part thereof and any amounts so paid including Lender's Expenses incurred shall become Obligations, immediately
due and payable, bearing interest at the Default Rate, and secured by the Collateral. Any such payments by Lender shall not constitute an agreement to make similar payments or a waiver of any Event of
Default. 

        9.4    Remedies Cumulative.    Lender's rights and remedies under the
Loan Documents and all other agreements with Borrower shall be cumulative. Lender shall have all other rights and remedies as
provided under the UCC, by law, or in equity. No exercise by Lender of one right or remedy shall be deemed an election, and no waiver by Lender of any Event of Default shall be deemed a continuing
waiver. No delay by Lender shall constitute a waiver, election, or acquiescence. 

        9.5    Application of Collateral Proceeds.    Lender will apply
proceeds of sale, to the extent actually received in cash, in the manner and order it determines in its sole discretion, and as prescribed by applicable law. 

10.    WAIVERS; INDEMNIFICATION  

        10.1    Waivers.    Without limiting the generality of the other
waivers made by Borrower herein, to the maximum extent permitted under applicable law, Borrower hereby irrevocably waives all of the following: (i) any
right to assert against Lender as a defense, counterclaim, set-off or crossclaim, any defense (legal or equitable), set-off,
counterclaim, crossclaim and/or other claim (a) which Borrower may now or at any time hereafter have against any party liable to Lender in any way or manner, or (b) arising directly or
indirectly from the present or future lack of perfection, sufficiency, validity and/or enforceability of any Loan Document, or any security interest;  (ii) presentment, demand and notice of presentment,
dishonor, notice of intent to accelerate, protest, default, nonpayment, maturity, release,
compromise, settlement, extension or renewal of any or all accounts, documents, instruments, chattel paper and guaranties at any time held by Lender on which Borrower may in any way be liable and
hereby ratifies and confirms whatever Lender may do in this regard; (iii) the benefit of all marshalling, valuation, appraisal and exemption laws;  (iv) the
right, if any, to require Lender to (a) proceed against any person liable for any of the Obligations as a condition to or before
proceeding hereunder; or (b) foreclose upon, sell or otherwise realize upon or collect or apply any other property, real or personal, securing any of the Obligations, as a condition to, or
before proceeding hereunder; (v) any demand for possession before the commencement of any suit or action to recover possession of Collateral; and  (vi) any
requirement that Lender retain possession and not dispose of Collateral until after trial or final judgment.
 

        10.2    Lender's Liability for Collateral.    Subject to the
applicable provisions of the UCC, Lender shall not in any way or manner be liable or responsible for: (i) the safekeeping of any Collateral;  (ii) any loss
or damage thereto occurring or arising in any manner or fashion from any cause; (iii) any
diminution in the value thereof; or (iv) any act or default of any carrier, warehouseman, bailee, forwarding agency, or other person or entity
whomsoever. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. Lender will have no responsibility for taking any steps to preserve rights against any parties
respecting any Collateral. Lender's powers hereunder are conferred 

10

 

solely
to protect its interest in the Collateral and do not impose any duty to exercise any such powers. None of Lender or any of its officers, directors, employees, agents or counsel will be liable
for any action lawfully taken or omitted to be taken hereunder or in connection herewith (excepting gross negligence or willful misconduct), nor under any circumstances have any liability to Borrower
for lost profits or other special, indirect, punitive, or consequential damages. Lender retains any documents delivered by Borrower only for its purposes and for such period as Lender, at its sole
discretion, may determine necessary, after which time Lender may destroy such records without notice to or consent from Borrower. 

        10.3    Indemnification.    Borrower shall, on an after tax basis,
defend, indemnify, and hold Lender and each of its officers, directors, employees, counsel, partners, agents and attorneys-in-fact (each, an
"Indemnified Person") harmless from and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, costs,
charges, expenses or disbursements (including Lender's Expenses and reasonable attorney's fees and the allocated cost of in-house counsel) of any kind or nature whatsoever with respect to
the execution, delivery, enforcement, performance and administration of this Agreement and any other Loan Documents, or the transactions contemplated hereby and thereby, with respect to noncompliance
with laws or regulations respecting Regulated Substances, government secrecy or technology export, or any Lien not created by Lender or right of another against any Collateral, even if the Collateral
is foreclosed upon or sold pursuant hereto, and with respect to any investigation, litigation or proceeding before any agency, court or other governmental authority relating to this Agreement or the
Advances or the use of the proceeds thereof, whether or not any Indemnified Person is a party thereto (all the foregoing, collectively, the "Indemnified
Liabilities"); provided, that Borrower shall have no obligation hereunder to any Indemnified Person with respect to Indemnified
Liabilities arising from the gross negligence or willful misconduct of such Indemnified Person. The obligations in this Section shall survive the Term. At the election of any Indemnified Person,
Borrower shall defend such Indemnified Person using legal counsel satisfactory to such Indemnified Person, at the sole cost and expense of Borrower. All amounts owing under this Section shall be paid
within 30 days after written demand. 

11.    NOTICES  

        All notices shall be in writing and personally delivered or sent by certified mail, postage prepaid, return receipt requested, or by
confirmed facsimile, at the respective addresses set forth below: 

 

 

			
	If to Borrower:	 	 If to Lender:
	
 Anacor Pharmaceuticals, Inc.

1060 E. Meadow Circle

Palo Alto, California 94303

Attention: Chief Financial Officer

FAX: (650) 739-0139	
 	
 Lighthouse Capital Partners V, LP

500 Drake's Landing Road

Greenbrae, California 94904

Attention: Contract Administrator

FAX: (415) 925-3387

 

 12.    GENERAL PROVISIONS  

        12.1    Successors and Assigns.    This Agreement shall bind and inure
to the benefit of the parties' respective successors and permitted assigns. Borrower may not assign any rights hereunder without Lender's prior written consent, which consent may be granted or
withheld in Lender's reasonable sole discretion. Lender shall have the right without the consent of or notice to Borrower to sell, transfer, negotiate, or grant participations in all or any part of
any Loan Document. 

        12.2    Time of Essence.    Time is of the essence for the performance
of all Obligations. 

        12.3    Severability of Provisions.    Each provision hereof shall be
severable from every other provision in determining its legal enforceability. 

11

 

        12.4    Entire Agreement.    This Agreement and each of the other Loan
Documents dated as of the date hereof, taken together, constitute and contain the entire agreement between Borrower and Lender with respect to their subject matter and supersede any and all prior
agreements, negotiations, correspondence, understandings and communications between the parties, whether written or oral. This Agreement is the result of negotiations between and has been reviewed by
the Borrower and Lender as of the date hereof and their respective counsel; accordingly, this Agreement shall be deemed to be the product of the parties
hereto, and no ambiguity shall be construed in favor of or against Borrower or Lender. This Agreement may only be modified with the written consent of Lender. Any waiver or consent with respect to any
provision of the Loan Documents shall be effective only in the specific instance and for the specific purpose for which it was given. No notice to or demand on Borrower in any one case shall entitle
Borrower to any other or further notice or demand in similar or other circumstances. 

        12.5    Reliance by Lender.    All covenants, agreements,
representations and warranties made herein by Borrower shall, notwithstanding any investigation by Lender, be deemed to be material to and to have been relied upon by Lender. 

        12.6    No Set-Offs by Borrower.    All sums payable by
Borrower pursuant to this Agreement or any of the other Loan Documents shall be payable without notice or demand and shall be payable in United States Dollars without set-off or reduction
of any manner whatsoever. 

        12.7    Counterparts.    This Agreement may be executed in any number
of counterparts, each of which shall be deemed to be an original, and all of which, when taken together, shall constitute one and the same original instrument. 

        12.8    Survival.    All covenants, representations and warranties
made in this Agreement shall continue in full force and effect so long as any Obligations remain outstanding. 

        12.9    No Original Issue Discount.    Borrower and Lender acknowledge
and agree that the Warrant is part of an investment unit within the meaning of Section 1273(c)(2) of the Internal Revenue Code, which includes the Loan. Borrower and Lender further agree as
between them, that the fair market value of the Warrant is $100 and that, pursuant to Treas. Reg. § 1.1273-2(h), $100
of the issue price of the investment unit will be allocable to the Warrant and the balance shall be allocable to the Loans. Borrower and Lender agree to prepare their federal income tax returns in a
manner consistent with the foregoing and, pursuant to Treas. Reg. § 1.1273, the original issue discount on the Loan shall be considered to be zero. 

        12.10    Relationship of Parties.    The relationship between Borrower
and Lender is, and at all times shall remain, solely that of a borrower and lender. Lender is not a partner or joint venturer of Borrower; nor shall Lender under any circumstances be deemed to be in a
relationship of confidence or trust or have a fiduciary relationship with Borrower or any of its affiliates, or to owe any fiduciary duty to Borrower or any of its affiliates. Lender does not
undertake or assume any responsibility or duty to Borrower or any of its affiliates to select, review, inspect, supervise, pass judgment upon or otherwise inform any of them of any matter in
connection with its or their property, the Loans, any Collateral or the operations of Borrower or any of its affiliates. Borrower and each of its affiliates shall rely entirely on their own judgment
with respect to such matters, and any review, inspection, supervision, exercise of judgment or supply of information undertaken or assumed by Lender in connection with such matters is solely for the
protection of Lender and neither Borrower nor any affiliate is entitled to rely thereon. 

        12.11    Confidentiality.    Lender and Borrower agree that, except
with the prior written permission of the other party, the parties shall at all times hold in confidence and trust and not use or disclose any confidential information provided or learned by such party
in connections with it's rights under the Loan Documents. Notwithstanding the foregoing, the parties may disclose any confidential information 

12

 

of
the other party provided to or learned by such party in connection with such rights to the minimum extent necessary (i) in connection with the
enforcement of this Agreement or rights under this Agreement or the Loan Documents; (ii) as required by any court or other governmental body,  provided that
such party provides the other party with prompt notice of such court order or requirement to enable the party to seek a protective order
or otherwise to prevent or restrict such disclosure; (iii) to legal counsel or such party; (iv) to
comply with applicable law; or (v) with respect to financial information concerning the Borrower, to Lender's limited and general partners in accordance
with Lender's customary investment reporting practices. 

        12.12    Choice of Law and Venue; Jury Trial
Waiver.    THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD
TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE JURISDICTION AND VENUE OF THE STATE AND FEDERAL COURTS LOCATED IN THE CITY AND COUNTY OF SAN FRANCISCO,
STATE OF CALIFORNIA. BORROWER AND LENDER HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE LOAN DOCUMENTS OR ANY OF THE
TRANSACTIONS CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW OR STATUTORY CLAIMS. EACH PARTY FURTHER WAIVES ANY RIGHT TO CONSOLIDATE ANY
ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER ACTION IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.  

        IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. 

 

 

							
	 ANACOR PHARMACEUTICALS, INC.	 	Lighthouse Capital Partners V, L.P.
	

 	
 	
 	
 	
 By:	
 	
 LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner
	
By:	
 	
 /s/ LUCY DAY

 	
 	
 By:	
 	
 /s/ THOMAS CONNEELY

 
	
Name:	
 	
 Lucy O. Day

 	
 	
 Name:	
 	
 Thomas Conneely

 
	
Title:	
 	
 CFO

 	
 	
 Title:	
 	
 Vice President

 

 

 13

 
 

 

			
	Exhibit A	 	Collateral Description
	Exhibit B	 	Form of Note
	Exhibit C	 	Form of Preferred Stock Warrant
	Exhibit D	 	Form of Notice of Borrowing
	Exhibit E	 	Form of Incumbency Certificate
	Exhibit F	 	Form of Officers Certificate
	Exhibit G	 	ACH Authorization
	Exhibit H	 	Form of Negative Pledge Agreement
	Exhibit I	 	Control Agreement

 

 14

 

   EXHIBIT A  

 COLLATERAL  

        This FINANCING STATEMENT and SECURITY AGREEMENT covers all of Debtor's interests in all of the following types or items of property,
wherever located and whether now owned or hereafter acquired, and Debtor hereby grants Secured Party a security interest therein as collateral for the payment and performance of all present and future
indebtedness, liabilities, guarantees and obligations of Debtor to Secured Party, howsoever arising. Debtor agrees that said security interest may be enforced by Secured Party in accordance with the
terms of all security and other agreements between Secured Party and Debtor, the California Uniform Commercial Code, or both, and that this document shall be fully effective as a security agreement,
even if there is no other security or other agreement between Secured Party or Debtor: 

        All
assets of the Debtor; all personal property of Debtor; 

        All
"accounts", "general intangibles", "chattel paper", "contract rights", "documents", "instruments", "deposit accounts", "inventory", "farm products", "fixtures" and "equipment", as
such terms are defined in Division 9 of the California Uniform Commercial Code in effect on the date hereof; 

        All
general intangibles of every kind, including without limitation, federal, state and local tax refunds and claims of all kinds; all rights as a licensee or any kind; all customer
lists, telephone numbers, and purchase orders, and all rights to purchase, lease sell, or otherwise acquire or deal with real or personal property and all rights relating thereto; 

        All
returned and repossessed goods and all rights as a seller of goods; all collateral securing any of the foregoing; all deposit accounts, special and general, whether on deposit with
Secured Party or others; 

        All
life and other insurance policies, claims in contract, tort or otherwise, and all judgments now or hereafter arising therefrom; 

        All
right, title and interest of Debtor, and all of Debtor's rights, remedies, security and liens, in, to and in respect of all accounts and other collateral, including, without
limitation, rights of stoppage in transit, replevin, repossession and reclamation and other rights and remedies of an unpaid vendor, lienor or secured party, and all guarantees and other contracts of
suretyship with respect to any accounts and other collateral, and all deposits and other security for any accounts and other collateral, and all credit and other insurance; 

        All
notes, drafts, letters of credit, contract rights, and things in action; all drawings, specifications, blueprints and catalogs; and all raw materials, work in process, materials used
or consumed in Debtor's business, goods, finished goods, returned goods and all other goods and inventory of whatsoever kind or nature, any and all wrapping, packaging, advertising and shipping
materials, and all documents relating thereto, and all labels and other devices, names and marks affixed or to be affixed thereto for purposes of selling or identifying the same or the seller or
manufacturer thereof; 

        All
inventory, raw materials and work in progress wherever located; all present and future claims against any supplier of any of the foregoing, including claims for defective goods or
overpayments to or undershipments by suppliers; all proceeds arising from the lease or rental of any of the foregoing; INVENTORY RETURNED BY DEBTOR TO ITS SUPPLIERS SHALL REMAIN SUBJECT TO SECURED
PARTY'S SECURITY INTEREST; 

        All
equipment and fixtures, NONE OF WHICH THE DEBTOR IS AUTHORIZED TO SELL, LEASE OR OTHERWISE DISPOSE OF WITHOUT THE WRITTEN CONSENT OF SECURED PARTY, including without limitation all
machinery, machine tools, motors, controls, parts, vehicles, 

1

 

workstations,
tools, dies, jigs, furniture, furnishings and fixtures; and all attachments, accessories, accessions and property now or hereafter affixed to or used in connection with any of the
foregoing, and all substitutions and replacements for any of the foregoing; all warranty and other claims against any vendor or lessor of any of the foregoing; 

        All
investment property; 

        All
books, records, ledger cards, computer data and programs and other property and general intangibles at any time evidencing or relating to any or all of the foregoing; and 

        All
cash and non-cash products and proceeds of any of the foregoing, in whatever form, including proceeds in the form of inventory, equipment or any other form of personal
property, including proceeds of proceeds and proceeds of insurance, and all claims by Debtor against third parties for loss or damage to, or destruction of, or otherwise relating to, any or all of the
foregoing. 

        NOTICE—PURSUANT
TO AN AGREEMENT BETWEEN DEBTOR AND SECURED PARTY, DEBTOR HAS AGREED NOT TO FURTHER ENCUMBER THE COLLATERAL DESCRIBED HEREIN, THE FURTHER ENCUMBERING OF WHICH
MAY CONSTITUTE THE TORTIOUS INTERFERENCE WITH SECURED PARTY'S RIGHTS BY SUCH ENCUMBRANCER. IN THE EVENT THAT ANY ENTITY IS GRANTED A SECURITY INTEREST IN DEBTOR'S ACCOUNTS, CHATTEL PAPER, GENERAL
INTANGIBLES OR OTHER ASSETS CONTRARY TO THE ABOVE, THE SECURED PARTY ASSERTS A CLAIM TO ANY PROCEEDS THEREOF RECEIVED BY SUCH ENTITY. 

        Notwithstanding
any of the foregoing, this Financing Statement and Security Agreement does not cover any of Debtor's interests in, and the Collateral shall not under any circumstance
include, and no security interest is granted in, Debtor's Intellectual Property, including, without limitation, any and all property of the Debtor that is subject to, listed in or otherwise described
in the Negative Pledge Agreement dated June 30, 2006 between the Secured Party and the Debtor. "Intellectual Property" means, collectively, all
rights, priorities and privileges of the Debtor relating to intellectual property, in any medium, of any kind or nature whatsoever, now or hereafter owned or acquired or received by Debtor, or in
which Debtor now holds or hereafter acquires or receives any right or interest, whether arising under United States, multinational or foreign laws or otherwise, and shall include, in any event, all
copyrights, copyright licenses, patents, patent licenses, trademarks, trademark licenses, trade secrets, internet domain names (including any right related to the registration thereof), proprietary or
confidential information, mask works, sources object or other programming codes, inventions (whether or not patented or patentable), technical information, procedures, designs, knowledge,
know-how, software, data base, data, skill, expertise, recipe, experience, process, models, drawings, materials or records. Notwithstanding the foregoing, Intellectual Property as defined
above does not include accounts, accounts receivable, royalties, licensing fees, contract rights, proceeds, or other revenue obtained or owed from or on account of the licensing or other exploitation
of Intellectual Property, 

2

 

none
of which are excluded, and all of which are included as collateral in the security interest granted by Debtor to Secured Party. 

 

							
	 "DEBTOR"	 	"SECURED PARTY"
	
ANACOR PHARMACEUTICALS, INC.,	
 	
 LIGHTHOUSE CAPITAL PARTNERS V, L.P.
	a Delaware corporation	 	 BY:	 	LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C.,

its general partner
	By:	 	

 	 	 	 	 
	Name:	 	

 	 	By:	 	 

 
	Title:	 	

 	 	Name:	 	 

 
	 	 	 	 	Title:	 	

 

 

 3

 

 EXHIBIT B  

[                        ]

SECURED PROMISSORY NOTE  

        THIS SECURED PROMISSORY NOTE (this
"Note") is made                        , 200    , by
ANACOR PHARMACEUTICALS, INC.
("Borrower") in favor of LIGHTHOUSE CAPITAL PARTNERS V, L.P. (collectively with its assigns,
"Lender"). Initially capitalized terms used and not otherwise defined herein are defined in that certain Loan and Security Agreement No. 5251
between Borrower and Lender dated June 30, 2006 (the "Loan Agreement"). 

        FOR VALUE RECEIVED, Borrower promises to pay in lawful money of the United States, to the order of Lender, at 500 Drake's Landing Road,
Greenbrae, California 94904, or such other place as Lender may from time to time designate ("Lender's Office"), the principal sum of
$                        
(the "Advance"), including interest on the unpaid balance and all other amounts due or to become due hereunder according to the terms hereof and of the Loan Agreement. 

        "Basic Rate" means a variable per annum rate of interest equal to the Index plus the
Interest Margin which shall be subject to adjustment as provided in the Loan Agreement. On and after the Loan Commencement Date, the Basic Rate shall be fixed and not subject to any further
adjustments. 

        "Final Payment" means 9.5% of the Advance. 

        "Index" means the prevailing variable Prime Rate of annual interest as quoted from time to time in the western edition of the Wall Street
Journal. 

        "Interest Margin" means 2% per annum. 

        "Loan Commencement Date" means January 1, 2008. 

        "Maturity Date" means the last day of the Repayment Period, or if earlier, the date of prepayment under the Note. 

        "Payment Date" means the first day of each calendar month. 

        "Prepayment Fee" means (i) 3% of the outstanding principal amount being prepaid if such
prepayment is made in calendar year 2006 or 2007; (ii) 2% of the outstanding principal amount being prepaid if such prepayment is made in calendar year
2008, or (iii) 1% of the outstanding principal amount being prepaid if such prepayment is made in calendar year 2009 or thereafter. 

        "Repayment Period" means the period beginning on the Loan Commencement Date and continuing for 30 calendar months. 

        1.    Repayment.    Borrower shall pay principal and interest due
hereunder from the Funding Date, until this Note is paid in full, on each Payment Date pursuant to the terms of the Loan Agreement and this Note. Prior to the Loan Commencement Date, Borrower shall
pay to Lender, monthly in advance on each Payment Date, interest calculated using the Basic Rate prevailing on the first business day of such calendar month. Beginning on the Loan Commencement Date
and on each Payment Date thereafter during the Repayment Period, Borrower shall make equal installments of principal and interest in advance, calculated at the Basic Rate. On the Maturity Date,
Borrower shall pay, in addition to all unpaid principal and interest outstanding hereunder, the Final Payment. 

        2.    Interest.    Interest not paid when due will, to the maximum
extent permitted under applicable law, become part of principal, at Lender's option, and thereafter bear like interest as principal. All interest computation shall be based on a 360-day
year and actual days elapsed. All Obligations not paid when due shall bear interest at the Default Rate unless waived in writing by Lender. All amounts paid 

1

 

hereunder
will be applied to the Obligations in Lender's discretion and as provided in the Loan Agreement. 

        3.    Voluntary Prepayment.    Borrower may prepay the Note if and
only if Borrower pays to Lender (i) the outstanding principal amount of this Note and any unpaid accrued interest;  (ii) the Final Payment; (iii) the Prepayment Fee; and  (iv) all other sums, if any, that shall have become due and payable hereunder with respect to this Note. 

        4.    Collateral.    This Note is secured by the Collateral. 

        5.    Waivers.    Borrower, and all guarantors and endorsers of this
Note, regardless of the time, order or place of signing, hereby waive notice, demand, presentment, protest, and notices of every kind, presentment for the purpose of accelerating maturity, diligence
in collection, and, to the fullest extent permitted by law, all rights to plead any statute of limitations as a defense to any action on this Note. 

        6.    Choice of Law; Venue.    THIS NOTE SHALL
BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE
EXCLUSIVE JURISDICTION AND VENUE OF THE STATE AND FEDERAL COURTS LOCATED IN THE CITY AND COUNTY OF SAN FRANCISCO, STATE OF CALIFORNIA. BORROWER AND LENDER EACH HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO
A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS NOTE. EACH PARTY FURTHER WAIVES ANY RIGHT TO CONSOLIDATE ANY ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER
ACTION IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.  

        7.    Miscellaneous.    THIS
NOTE MAY BE MODIFIED ONLY BY A WRITING SIGNED BY BORROWER AND LENDER. Each provision hereof is severable from every other provision hereof and of the Loan Agreement when
determining its legal enforceability. Sections and subsections are titled for convenience, and not for construction. "Hereof," "herein," "hereunder," and similar words refer to this Note in its
entirety. "Or" is not necessarily exclusive. "Including" is not limiting. The terms and conditions hereof inure to the benefit of and are binding upon the parties' respective permitted successors and
assigns. This Note is subject to all the terms and conditions of the Loan Agreement. 

        IN WITNESS WHEREOF, Borrower has caused this Note to be executed by a duly authorized officer as of the day and year first above written. 

 

 

					
	 
	 	   ANACOR PHARMACEUTICALS, INC.

	 
	 	  By:
	 	 

 
	 
	 	  Name:
	 	 

 
	 
	 	  Title:
	 	 

 

 

 2

 

  EXHIBIT C  

THIS
WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "1933 ACT"), OR ANY APPLICABLE STATE SECURITIES LAWS, AND
MAY NOT BE SOLD OR TRANSFERRED UNLESS SUCH SALE OR TRANSFER IS IN ACCORDANCE WITH THE REGISTRATION REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS OR SOME OTHER EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS IS AVAILABLE WITH RESPECT THERETO. 

PREFERRED
STOCK PURCHASE WARRANT 

Warrant
No.                                    

Number
of Shares: a maximum of 300,578

Series D Preferred Stock

Subject to determination as set for the below 

ANACOR PHARMACEUTICALS, INC.  

Effective
as of June 30, 2006 

Void
after June 30, 2013 

        1.    Issuance.    This Preferred Stock Purchase Warrant (the
"Warrant") is issued to LIGHTHOUSE CAPITAL PARTNERS V, L.P. by ANACOR
PHARMACEUTICALS, INC., a Delaware corporation (hereinafter with its successors called the "Company"). 

        2.    Purchase Price; Number of Shares.    

        (a)   The registered holder of this Warrant (the "Holder"), is entitled upon
surrender of this Warrant with the subscription form annexed hereto duly executed, at the principal office of the Company, to purchase from the Company, at a price per share of $1.73 (the
"Purchase Price"), up to a maximum of 300,578 fully paid and nonassessable shares of the Company's Series D Preferred Stock, $0.001 per share par
value (the "Preferred Stock"). Commencing on the date hereof, 150,289 (the "Exercise Quantity") of
shares of Preferred Stock are immediately available for purchase hereunder. 

        (b)   On the Commitment Termination Date, or such earlier termination of this Warrant in accordance with the terms hereof, the
Exercise Quantity shall automatically be increased by such additional number of shares as is equal to (A) 3.25% of the amount of Aggregate Advances funded under the Loan Agreement, if any,
divided by (B) the Purchase Price, rounded down to the nearest whole number. 

In
addition to other terms which may be defined herein, the following terms, as used in this Warrant, shall have the following meanings: 

	(i)
	"Aggregate Advances" means the aggregate original dollar amount of Advances made under the Loan Agreement,
whether such Advances are outstanding or prepaid, at the time of any scheduled adjustment to the Exercise Quantity.

	(ii)
	"Loan Agreement" means that certain Loan and Security Agreement No. 5251 dated June 30, 2006
between the Company and Lighthouse Capital Partners V, L.P.. 

Any
term not defined herein shall have the meaning as set forth in the Loan Agreement. 

Until
such time as this Warrant is exercised in full or expires, the Purchase Price and the securities issuable upon exercise of this Warrant are subject to adjustment as hereinafter provided. The
person or persons in whose name or names any certificate representing shares of Preferred Stock is issued 

1

 

hereunder
shall be deemed to have become the holder of record of the shares represented thereby as at the close of business on the date this Warrant is exercised with respect to such shares, whether
or not the transfer books of the Company shall be closed. 

        3.    Payment of Purchase Price.    The Purchase Price may be paid (i) in cash or by check, (ii) by the
surrender by the Holder to the Company of any promissory notes or other obligations issued by the Company, with all such notes and obligations so surrendered being credited against the Purchase Price
in an amount equal to the principal amount thereof plus accrued interest to the date of surrender, or (iii) by any combination of the foregoing. 

        4.    Net Issue Election.    The Holder may elect to receive, without the payment by the Holder of any additional
consideration, shares of Preferred Stock equal to the value of this Warrant or any portion hereof by the surrender of this Warrant or such portion to the Company, with the net issue election notice
annexed hereto duly executed, at the principal office of the Company. Thereupon, the Company shall issue to the Holder such number of fully paid and nonassessable shares of Preferred Stock as is
computed using the following formula: 

							
	 	 	 X=	 	 Y(A-B)

 A	 	 

				
	 	where: X =	 	the number of shares of Preferred Stock to be issued to the Holder pursuant to this Section 4.
	
 	
Y =	
 	
the number of shares of Preferred Stock covered by this Warrant in respect of which the net issue election is made pursuant to this Section 4.
	
 	
A =	
 	
the Fair Market Value (defined below) of one share of Preferred Stock, as determined at the time the net issue election is made pursuant to this Section 4.
	
 	
B =	
 	
the Purchase Price in effect under this Warrant at the time the net issue election is made pursuant to this Section 4.

        "Fair Market Value" of a share of Preferred Stock (or fully paid and nonassessable shares of the Company's common stock, $0.001 par value
(the "Common Stock") if the Preferred Stock has been automatically converted into Common Stock) as of the date that the net issue election is made (the
"Determination Date") shall mean: 

        (i)    If the net issue election is made in connection with and contingent upon the closing of the sale of the Company's Common
Stock to the public in a public offering pursuant to a Registration Statement under the 1933 Act (a "Public Offering"), and if the Company's
Registration Statement relating to such Public Offering ("Registration Statement") has been declared effective by the Securities and Exchange
Commission, then the initial "Price to Public" specified in the final prospectus with respect to such offering multiplied by the number of shares of Common Stock into which each share of Preferred
Stock is then convertible. 

        (ii)   If the net issue election is not made in connection with and contingent upon a Public Offering, then as follows: 

        (a)   If traded on a securities exchange or the Nasdaq National Market, the fair market value of the Common Stock shall be
deemed to be the average of the closing or last reported sale prices of the Common Stock on such exchange or market over the five day period ending five trading days prior to the Determination Date,
and the fair market value of the Preferred Stock shall be deemed to be such fair market value of the Common Stock multiplied by the number of shares of Common Stock into which each share of Preferred
Stock is then convertible; 

2

 

        (b)   If otherwise traded in an over-the-counter market, the fair market value of the Common Stock
shall be deemed to be the average of the closing ask prices of the Common Stock over the five day period ending five trading days prior to the Determination Date, and the fair market value of the
Preferred Stock shall be deemed to be such fair market value of the Common Stock multiplied by the number of shares of Common Stock into which each share of Preferred Stock is then convertible; and 

        (c)   If there is no public market for the Common Stock, then fair market value shall be determined in good faith by the
Company's Board of Directors. 

        5.    Partial Exercise.    This Warrant may be exercised in part, and the Holder shall be entitled to receive a new
warrant, which shall be dated as of the date of this Warrant, covering the number of shares in respect of which this Warrant shall not have been exercised. 

        6.    Fractional Shares.    In no event shall any fractional share of Preferred Stock be issued upon any exercise of
this Warrant. If, upon exercise of this Warrant in its entirety, the Holder would, except as provided in this Section 6, be entitled to receive a
fractional share of Preferred Stock, then the
Company shall issue the next lower number of full shares of Preferred Stock and shall pay to the Holder a cash amount equal to the Fair Market Value (as of the date of exercise) of such fractional
share of Preferred Stock. 

        7.    Expiration Date; Automatic Exercise.    This Warrant shall expire at the close of business on June 30,
2013, and shall be void thereafter (the "Expiration Date"). Notwithstanding the term of this Warrant fixed pursuant to this  Section 7, and provided
Holder has received advance written notice of at least ten (10) days and has not earlier exercised this Warrant,
and provided this Warrant has not been assumed by the successor entity (or parent thereof), upon the consummation of a Merger (as defined below), this Warrant shall automatically be exercised pursuant
to Section 4 hereof, without any action by Holder. "Merger" means: (i) a sale of all or
substantially all of the Company's assets to an Unaffiliated Entity (as defined below), or (ii) the merger, consolidation or acquisition of the Company with, into or by an Unaffiliated Entity
(other than a merger or consolidation for the principle purpose of changing the domicile of the Company or a bona fide round of preferred stock equity financing), that results in the transfer of fifty
percent (50%) or more of the outstanding voting power of the Company. "Unaffiliated Entity" means any entity that is owned or controlled by parties who
own less than twenty percent (20%) of the combined voting power of the voting securities of the Company immediately prior to such merger, consolidation or acquisition. Notwithstanding the foregoing,
in the event that any outstanding warrants to purchase equity securities of the Company are assumed by the successor entity of a Merger (or parent thereof), this Warrant shall also be similarly
assumed. The Company agrees to promptly give the Holder written notice of any proposed Merger and written notice of termination of any proposed Merger. Notwithstanding anything to the contrary in this
Warrant, the Holder may rescind any exercise of its purchase rights after a notice of termination of the proposed Merger if the exercise of this Warrant occurred after the Company notified the Holder
that the Merger was proposed or if the exercise was otherwise precipitated by such proposed Merger, provided, however that such rescission right must be exercised within thirty (30) days of
receipt of such written notice of termination of the proposed Merger. In the event of such rescission, this Warrant will continue to be exercisable on the same terms and conditions. 

        8.    Reserved Shares; Valid Issuance.    The Company covenants that it will at all times from and after the date
hereof reserve and keep available such number of its authorized shares of Preferred Stock and Common Stock free from all preemptive or similar rights therein, as will be sufficient to permit,
respectively, the exercise of this Warrant in full and the conversion into shares of Common Stock of all shares of Preferred Stock receivable upon such exercise. The Company further represents that
such shares as may be issued pursuant to such exercise and/or conversion will, upon issuance, be 

3

 

duly
and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to the issuance thereof. 

        9.    Stock Splits and Dividends.    If after the date hereof the Company shall subdivide the Preferred Stock, by
split-up or otherwise, or combine the Preferred Stock, or issue additional shares of Preferred Stock in payment of a stock dividend on the Preferred Stock, the number of shares of
Preferred Stock issuable on the exercise of this Warrant shall forthwith be proportionately increased in the case of a subdivision or stock dividend, or proportionately decreased in the case of a
combination,
and the Purchase Price shall forthwith be proportionately decreased in the case of a subdivision or stock dividend, or proportionately increased in the case of a combination. 

        10.    Adjustments for Diluting Issuances.    The other antidilution rights applicable to the Preferred Stock and the
Common Stock of the Company are set forth in the Amended and Restated Certificate of Incorporation, as amended from time to time (the "Articles"), a
true and complete copy in its current form which is attached hereto as Exhibit A. Such rights shall not be restated, amended or modified in any
manner which affects the Holder differently than the holders of Preferred Stock without such Holder's prior written consent. The Company shall promptly provide the Holder hereof with any restatement,
amendment or modification to the Articles promptly after the same has been made. 

        11.    Reclassifications.    If after the date hereof the Company shall enter into any Reorganization (as hereinafter
defined), then, as a condition of such Reorganization, lawful provisions shall be made, and duly executed documents evidencing the same from the Company or its successor shall be delivered to the
Holder, so that the Holder shall thereafter have the right to purchase, at a total price not to exceed that payable upon the exercise of this Warrant in full, the kind and amount of shares of stock
and other securities and property receivable upon such Reorganization by a holder of the number of shares of Preferred Stock which might have been purchased by the Holder immediately prior to such
Reorganization, and in any such case appropriate provisions shall be made with respect to the rights and interest of the Holder to the end that the provisions hereof (including without limitation,
provisions for the adjustment of the Purchase Price and the number of shares issuable hereunder and the provisions relating to the net issue election) shall thereafter be applicable in relation to any
shares of stock or other securities and property thereafter deliverable upon exercise hereof. For the purposes of this Section 11, the term
"Reorganization" shall include any reclassification, capital reorganization (other than as a result of a subdivision, combination or stock dividend
provided for in Section 9 hereof). 

        12.    Certificate of Adjustment.    Whenever the Purchase Price is adjusted, as herein provided, the Company shall
promptly deliver to the Holder a certificate of the Company's chief financial officer setting forth the Purchase Price after such adjustment and setting forth a brief statement of the facts requiring
such adjustment. 

        13.    Notices of Record Date, Etc.    In the event of: 

        (a)   any taking by the Company of a record of the holders of any class of securities for the purpose of determining the
holders thereof who are entitled to receive any dividend or other distribution, or any right to subscribe for, purchase, sell or otherwise acquire or dispose of any shares of stock of any class or any
other securities or property, or to receive any other right; 

        (b)   any reclassification of the capital stock of the Company, capital reorganization of the Company, consolidation or merger
involving the Company, or sale or conveyance of all or substantially all of its assets; or 

        (c)   any voluntary or involuntary dissolution, liquidation or winding-up of the Company; 

4

 

then
in each such event the Company will provide or cause to be provided to the Holder a written notice thereof. Such notice shall be provided at least ten (10) business days prior to the date
specified in such notice on which any such action is to be taken. 

        14.    Representations, Warranties and Covenants.    This Warrant is issued and delivered by the Company and accepted
by each Holder on the basis of the following representations, warranties and covenants made by the Company: 

        (a)   The Company has all necessary authority to issue, execute and deliver this Warrant and to perform its obligations
hereunder. This Warrant has been duly authorized issued, executed and delivered by the Company and is the valid and binding obligation of the Company, enforceable in accordance with its terms. 

        (b)   The shares of Preferred Stock issuable upon the exercise of this Warrant have been duly authorized and reserved for
issuance by the Company and, when issued in accordance with the terms hereof, will be validly issued, fully paid and nonassessable. 

        (c)   The issuance, execution and delivery of this Warrant do not, and the issuance of the shares of Preferred Stock upon the
exercise of this Warrant in accordance with the terms hereof will not, (i) violate or contravene the Company's Articles or by-laws, or any law, statute, regulation, rule, judgment
or order applicable to the Company, (ii) violate, contravene or result in a breach or default under any contract, agreement or instrument to which the Company is a party or by which the Company
or any of its assets are bound or (iii) require the consent or approval of or the filing of any notice or registration with any person or entity, except for filings required under California
securities laws. 

        (d)   As long as this Warrant is, or any shares of Preferred Stock issued upon exercise of this Warrant or any shares of Common
Stock issued upon conversion of such shares of Preferred Stock are, issued and outstanding, the Company will provide to the Holder the financial information described in the Loan Agreement. 

        (e)   As of June 15, 2006 hereof, the authorized capital stock of the Company consists of (i) 51,150,000 shares
of Common Stock, of which 6,051,283 shares are issued and outstanding and 300,578 shares are reserved for issuance upon the exercise of this Warrant with respect to Common Stock and the conversion of
the Preferred Stock into Common Stock if this Warrant is exercised with respect to Preferred Stock, and (ii) 4,228,329 shares of Series A-1 Preferred Stock, of which
4,228,329 are issued and outstanding shares; (iii) 1,198,046 shares of Series A-2 Preferred Stock, of which 1,198,046 are issued and outstanding shares (iv) 3,339,341
shares of Series B Preferred Stock, of which 3,339,341 are issued and outstanding shares; (v) 28,089,885 shares of Series C Preferred Stock, of which 28,089,885 are issued and
outstanding shares and (vi) 3,400,000 shares of Series D Preferred Stock, of which 2,930,500 are issued and outstanding shares. Attached hereto as  Exhibit B is a capitalization
table summarizing the capitalization of the Company. At the request of Holder, not more than once per calendar
quarter, the Company will provide Holder with a current capitalization table indicating changes, if any, to the number of outstanding shares of common stock and preferred stock. 

        15.    Registration Rights.    The Company has entered into an Amended and Restated Investors' Rights Agreement in the
form attached hereto as Exhibit C. 

        16.    Amendment.    The terms of this Warrant may be amended, modified or waived only with the written consent of the
Holder. 

        17.    Representations and Covenants of the Holder.    This Warrant has been entered into by the Company in reliance
upon the following representations and covenants of the Holder, which by its execution hereof the Holder hereby confirms: 

5

 

        (a)    Investment Purpose.    The right to acquire Preferred Stock or
the Preferred Stock issuable upon exercise of the Holder's rights contained herein will be acquired for investment and not with a view to the sale or distribution of any part thereof, and the Holder
has no present intention of selling or engaging in any public distribution of the same except pursuant to a registration or exemption. 

        (b)    Accredited Investor.    Holder is an "accredited investor"
within the meaning of the Securities and Exchange Rule 501 of Regulation D, as presently in effect. 

        (c)    Private Issue.    The Holder understands (i) that the
Preferred Stock issuable upon exercise of the Holder's rights contained herein is not registered under the 1933 Act or qualified under applicable
state securities laws on the ground that the issuance contemplated by this Warrant will be exempt from the registration and qualifications requirements thereof, and (ii) that the Company's
reliance on such exemption is predicated on the representations set forth in this Section 17. 

        (d)    Financial Risk.    The Holder has such knowledge and experience
in financial and business matters as to be capable of evaluating the merits and risks of its investment and has the ability to bear the economic risks of its investment. 

        (e)    Legends.    The Holder understands that the Securities, and any
securities issued in respect thereof or exchange therefor, may bear one or all of the following legends: 

        (i)    "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND
HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933." 

        (ii)   Any legend required by the Blue Sky laws of any state to the extent such laws are applicable to the shares represented
by the certificate so legended. 

        (f)    Lock-up Agreement.    In connection with the
initial public offering of the Company's securities and upon request of the Company or the underwriters managing such offering of the Company's securities, the Holder agrees not to sell, make any
short sale of, loan, grant any option for the purchase of, or otherwise dispose of any securities of the Company, however or whenever acquired (other than those included in the registration) without
the prior written consent of the Company or such underwriters, as the case may be, for such period of time (not to exceed 180 days or such longer period as may be required by the underwriters
to comply with NASD Rule 2711) from the effective date of such registration as may be requested by the Company or such managing underwriters and to execute an agreement reflecting the foregoing
as may be requested by the underwriters at the time of the Company's initial public offering. 

        The
obligations described in this Section 17(f) shall apply only if all executive officers and directors of the Company, and all 1%
and greater security holders (on a basis assuming full conversion and exercise of all convertible or exercisable securities) enter into similar agreements. If the Company or the underwriter of any
public offering of the Company's securities waives or terminates any standoff or lockup restrictions imposed on any holder of securities of the Company, then such waiver or termination shall be
granted to all Holders subject to standoff or lockup restrictions pro rata based on the number of shares of Common Stock beneficially held by such
holder and the Holders. From and after the date of this Warrant, the Company shall use its best efforts to ensure that all holders of 

6

 

capital
stock of the Company agree to be bound by terms substantially similar to those set forth in this Section 17(f). 

        18.    Notices, Transfers, Etc.    

        (a)   Any notice or written communication required or permitted to be given to the Holder may be given by certified mail or
delivered to the Holder at the address most recently provided by the Holder to the Company. 

        (b)   Subject to compliance with applicable federal and state securities laws, this Warrant may be transferred by the Holder
with respect to not less than 25% of the number of the shares of Preferred Stock purchasable hereunder, provided that the transferee is not a competitor of the Company and provided further that the
transferee agrees to be bound by all of the terms and conditions of this Warrant, including, with limitations the representations and covenants contained in  Section 17. Upon surrender of this
Warrant to the Company, together with the assignment notice annexed hereto duly executed, for transfer of this
Warrant as an entirety by the Holder, the Company shall issue a new warrant of the same denomination to the assignee. Upon surrender of this Warrant to the Company, together with the assignment hereof
properly endorsed, by the Holder for transfer with respect to a portion of the shares of Preferred Stock purchasable hereunder, the Company shall issue a new warrant to the assignee, in such
denomination as shall be requested by the Holder hereof, and shall issue to such Holder a new warrant covering the number of shares in respect of which this Warrant shall not have been transferred.
Any purported transfer in violation of this Section 18(b) shall be void. 

        (c)   In case this Warrant shall be mutilated, lost, stolen or destroyed, the Company shall issue a new warrant of like tenor
and denomination and deliver the same (i) in exchange and substitution for and upon surrender and cancellation of any mutilated Warrant, or (ii) in lieu of any Warrant lost, stolen or
destroyed, upon receipt of an affidavit of the Holder or other evidence reasonably satisfactory to the Company of the loss, theft or destruction of such Warrant 

        19.    No Impairment.    The Company will not, by amendment of its Articles or through any reclassification, capital
reorganization, consolidation, merger, sale or conveyance of assets, dissolution, liquidation, issue
or sale of securities or any other voluntary action, avoid or seek to avoid the observance of performance of any of the terms of this Warrant. 

        20.    Governing Law.    The provisions and terms of this Warrant shall be governed by and construed in accordance
with the internal laws of the State of California without giving effect to its principles regarding conflicts of laws. 

        21.    Successors and Assigns.    This Warrant shall be binding upon the Company's successors and assigns and shall
inure to the benefit of the Holder's successors, legal representatives and permitted assigns. 

        22.    Business Days.    If the last or appointed day for the taking of any action required or the expiration of any
rights granted herein shall be a Saturday or Sunday or a legal holiday in California, then such action may be taken or right may be exercised on the next succeeding day which is not a Saturday or
Sunday or such a legal holiday. 

        23.    Qualifying Public Offering.    If the Company shall effect a firm commitment underwritten public offering of
shares of Common Stock which results in the conversion of the Preferred Stock into Common Stock pursuant to the Company's Articles in effect immediately prior to such offering, then, effective upon
such conversion, this Warrant shall change from the right to purchase shares of Preferred Stock to the right to purchase shares of Common Stock, and the Holder shall thereupon have the right to
purchase, at a total price equal to that payable upon the exercise of this Warrant in full, the number of shares of Common Stock which would have been receivable by the Holder upon the exercise of
this Warrant for shares of Preferred Stock immediately prior to such conversion of such shares of Preferred Stock into shares of Common Stock, and in such event appropriate provisions shall 

7

 

be
made with respect to the rights and interest of the Holder to the end that the provisions hereof (including, without limitation, the provisions for the adjustment of the Purchase Price and of the
number of shares purchasable upon exercise of this Warrant and the provisions relating to the net issue election) shall thereafter be applicable to any shares of Common Stock deliverable upon the
exercise hereof. 

        24.    Value.    The Company and the Holder agree that the value of this Warrant on the date of grant is $100. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	
/s/ LUCY O. DAY

 
	

 	
 	
Name:	
 	
Lucy O. Day

 
	

 	
 	
Title:	
 	
CFO

 

 

 8

  Subscription  

 

 

					
	To:	 	  

 	 	 
	
 Date:	
 	
  

 	
 	

 
	

The undersigned hereby subscribes
for                                    shares of Preferred Stock
covered by this Warrant. The certificate(s) for such shares shall be issued in the name of the undersigned or as otherwise indicated below:
	

  

  Signature	
 	

 
	

  

  Name for Registration	
 	

 
	

  

  Mailing Address

	
 	

 

 

 1

 Net Issue Election Notice  

 

 

							
	
To:	
 	
  

 	
 	
 Date:	
 	
    

 
	

The undersigned hereby elects under Section 4 to surrender the right to purchase shares of Preferred Stock pursuant to this Warrant. The certificate(s) for such shares issuable upon such net issue
election shall be issued in the name of the undersigned or as otherwise indicated below:
	

  

  Signature	
 	

 	
 	

 
	

  

  Name for Registration	
 	

 	
 	

 
	

 

  Mailing Address

	
 	

 	
 	

 

 

 1

 Assignment  

For
value received                                    hereby sells,
assigns and transfers unto 

 

 

			
	  

  [Please print or typewrite name and address of Assignee]

 

 the
within Warrant, and does hereby irrevocably constitute and
appoint                                    its attorney to transfer
the within Warrant on the books of the within named Company with full power of
substitution on the premises. 

 

 

					
	Dated:	 	  

 	 	 
	

  

  Signature	
 	

 
	

 

  Name for Registration	
 	

 
	

In the Presence of:	
 	

 
	

  

 	
 	

 

 

 1

EXHIBIT A

 Amended and Restated Certificate of Incorporation  

See attached pages.  

1 

EXHIBIT B

 Capitalization Table  

1 

EXHIBIT C

 Amended And Restated Investors' Rights Agreement  

 see attached pages  

1 

 

 EXHIBIT D  

 NOTICE OF BORROWING  

                    ,            

Lighthouse
Capital Partners V, L.P.

500 Drake's Landing Road

Greenbrae, CA 94904-3011 

        Ladies
and Gentlemen: 

        Reference
is made to the Loan and Security Agreement No. 5251 dated as of June 30, 2006 (as it has been and may be amended from time to time, the
"Loan Agreement," initially capitalized terms used herein as defined therein), between LIGHTHOUSE CAPITAL PARTNERS V,
L.P. and ANACOR PHARMACEUTICALS, INC. (the "Company") 

        The
undersigned is the President and CEO of the Company, and hereby irrevocably requests an Advance under the Loan Agreement, and in that connection certifies as follows: 

        1.     The
amount of the proposed Advance is $                        . The business day of the proposed Advance
is                        .
 

        2.     The
Loan Commencement Date for this Advance shall be January 1, 2008. 

        3.     As
of this date, no Event of Default, or event which with notice or the passage of time would constitute an Event of Default, has occurred and is continuing, or will
result from the making of the proposed Advance, and the representations and warranties of the Company contained in Section 5 of the Loan
Agreement are true and correct in all material respects, except as set forth in the Disclosure Schedule and any updates thereto delivered on or before the date hereof. 

        4.     No
event that could reasonably be expected to have a material adverse effect on the ability of Borrower to fulfill its obligations under the Loan Agreement has occurred
since the date of the most recent financial statements, submitted to you by the Company. 

        The
Company agrees to notify you promptly before the funding of the Advance if any of the matters to which I have certified above shall not be true and correct on the Funding Date. 

 

					
	 	 	Very truly yours,
	

 	
 	
 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	

 
	

 	
 	
Name:	
 	
Lucy O. Day

 
	

 	
 	
Title:	
 	
CFO

 

 

 1

 

 EXHIBIT E  

 INCUMBENCY CERTIFICATE  

        The undersigned, Lucy O. Day, hereby certifies that: 

        1.     He/She is the duly elected and acting Chief Financial Officer of ANACOR
PHARMACEUTICALS, INC., a Delaware corporation (the "Company"). 

        2.     That on the date hereof, each person listed below holds the office in the Company indicated opposite his or her name and
that the signature appearing thereon is the genuine signature of each such person: 

 

 

					
	NAME 	 	OFFICE 	 	SIGNATURE 
	 David Perry
	 	Chief Executive Officer	 	

 
	 Lucy O. Day
	 	 Chief Financial Officer
	 	 

 

 

         3.     Attached hereto as Exhibit A is a true and correct copy of the
Certificate of Incorporation of the Company, as amended, as in effect as of the date hereof. 

        4.     Attached hereto as Exhibit B is a true and correct copy of the
Bylaws of the Company, as amended, as in effect as of the date hereof. 

        5.     Attached hereto as Exhibit C is a copy of the resolutions of the
Board of Directors of the Company authorizing and approving the Company's execution, delivery and performance of a loan facility with Lighthouse Capital Partners V, L.P. 

        IN
WITNESS WHEREOF, the undersigned has executed this Incumbency Certificate on June    , 2006. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
 By:	
 	

 
	

 	
 	
 Name:	
 	
 Lucy O. Day

 
	

 	
 	
 Title:	
 	
 Chief Financial Officer

 

 

         I,
the Chief Executive Officer of the Company, do hereby certify that Lucy Day is the duly qualified, elected and acting Chief Financial Officer of the Company and that the above
signature is his or her genuine signature. 

        IN
WITNESS WHEREOF, the undersigned has executed and delivered this Incumbency Certificate on June    , 2006. 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
 By:	
 	

 
	

 	
 	
 Name:	
 	
 David Perry

 
	

 	
 	
 Title:	
 	
 Chief Executive Officer

 

 

 1

 

 EXHIBIT F  

 OFFICER'S CERTIFICATE  

        The undersigned, to induce LIGHTHOUSE CAPITAL PARTNERS V, L.P.
("Lender"), to extend or continue financial accommodations to ANACOR PHARMACEUTICALS, INC., a
Delaware corporation (the "Borrower") pursuant to the terms of that certain Loan and Security Agreement dated June 30, 2006 (the
"Loan Agreement"), hereby certifies that on the date hereof: 

	1.
	I am the duly elected and acting Chief Financial Officer of Borrower.

	2.
	I am a Responsible Officer as that term is defined in the Loan Agreement.

	3.
	The information submitted herewith is in fact what it purports to be.

	4.
	The information delivered herewith is true, correct and complete.

	5.
	Borrower is currently able to meet its obligations as they come due.

	6.
	I understand that Lender is relying upon the truthfulness, accuracy and completeness hereof in connection
with the Loan Agreement.

	7.
	I will advise you if it comes to my attention that, as of the date hereof, the information submitted herewith
was not in fact true, correct and complete. 

        IN
WITNESS WHEREOF, the undersigned has executed this Officer's Certificate on                        . 

 

 

					
	 
	 	 ANACOR PHARMACEUTICALS, INC.
	 
	 	  By:
	 	 

 
	 
	 	  Name:
	 	  Lucy O. Day

 
	 
	 	  Title:
	 	  CFO

 

 

 1

 

 EXHIBIT G  

 AUTHORIZATION FOR AUTOMATIC PAYMENT  

        The undersigned ANACOR PHARMACEUTICALS, INC.
("Borrower") authorizes LIGHTHOUSE CAPITAL PARTNERS V, L.P. and any and all affiliated funds
(collectively, "Lender") and the bank / financial institution ("Bank") named below to initiate
variable debit and/or credit entries to Borrower's deposit, checking or savings accounts as designated below and to cause funds transfers to an account of Lender as payment of any and all amounts due
under the Loan and Security Agreement between Borrower and Lender dated June 30, 2006 (the "Loan Agreement"). 

        1.     Lender is hereby authorized to initiate variable debit and/or credit transactions and resulting funds transfers in
Borrower's designated accounts with respect to amounts calculated by Lender to be due and owing to Lender by Borrower periodically under the Loan Agreement. Borrower consents to all such debit and/or
credit transactions and resulting funds transfers and hereby authorizes Lender to take all such actions as may be required by Bank with respect to such transactions. Borrower acknowledges and agrees
that such credit and/or debit entries may be made in amounts due under the Loan Agreement in order to cause timely payments as required by the terms of the Loan Agreement. 

        2.     Borrower hereby authorizes Lender to release to Bank all information concerning Borrower that may be necessary or
desirable for Bank to investigate or recover any erroneous funds transfers that may occur. 

        3.     Borrower acknowledges and agrees that all such debit and/or credit transactions and funds transfers are intended to be
made through an Automated Clearing House system and in compliance with the NACHA Rules and in compliance with Bank's security procedures. 

        4.     Borrower represents and warrants that the account information set forth below is accurate and complete and that each of
the account(s) set forth below is a business account maintained in Borrower's name and for Borrower's account. 

        This
Consent shall be effective as of June 30, 2006 and shall remain in effect until the Loan Agreement has been terminated. Any cancellation by Borrower of this consent shall
(i) be made in writing and (ii) delivered to Bank and Lender in such time as to afford Bank and Lender a reasonable opportunity to act on said cancellation. 

 

 

							
	Bank of America

 
	(Name of Borrower's Bank)
	
 530 Lytton Avenue,	
 	
Palo Alto,	
 	
CA	
 	
94301
	

  
	(Address of Bank)	 	(City)	 	(State)	 	(Zip Code)
	
 Bank Routing Number	
 	
 	
 	

 	
 	

 
	

  
	 	 	 (between these symbols "/:" ":/" on bottom left of check)
	
 Account Number:	
 	
 	
 	
(checking)	
 	

 
	 	 	

  	 	 

 

  Copy of a voided check is attached to this form  

 

 

					
	Borrower Name:	 	 ANACOR PHARMACEUTICALS, INC.	 	 
	
 Borrower Address:	
 	
 1060 E. Meadow Circle	
 	

 
	 	 	 Palo Alto, CA 94303	 	 
	Authorized by:	 	

 	 	 
	 	 	 Its: CFO

 	 	 

 

 1

 

 EXHIBIT H  

 NEGATIVE PLEDGE AGREEMENT  

        THIS NEGATIVE PLEDGE AGREEMENT is made as of June 30, 2006, by and between  ANACOR PHARMACEUTICALS,
 INC. ("Borrower") and LIGHTHOUSE CAPITAL PARTNERS
V, L.P. ("Lender"). 

        In
consideration of the Loan and Security Agreement between the parties of proximate date herewith (the "Loan Agreement"), Borrower agrees
as follows: 

        Except
as otherwise permitted in the Loan Agreement, Borrower shall not sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of Borrower's
intellectual property, including, without limitation, the following: 

        (a)   Any and all copyright rights, copyright applications, copyright registration and like protection in each work or
authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held
(collectively, the "Copyrights"); 

        (b)   Any and all trade secrets, and any and all intellectual property rights in computer software and computer software
products now or hereafter existing, created, acquired or held; 

        (c)   Any and all design rights which may be available to Borrower now or hereafter existing, created, acquired or held; 

        (d)   All patents, patent applications and like protections, including, without limitation, improvements, divisions,
continuations, renewals, reissues, extensions and continuations-in-part of the same, including, without limitation, the patents and patent applications (collectively, the
"Patents"); 

        (e)   Any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same
and like protections, and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks (collectively, the
"Trademarks"); 

        (f)    Any and all claims for damages by way of past, present and future infringements of any of the rights included above, with
the right, but not the obligation, to sue for an collect such damages for said use or infringement of the intellectual property rights identified above; 

        (g)   Any and all licenses or other rights to use any of the Copyrights, Patents or Trademarks and all license fees and
royalties arising from such use to the extent permitted by such license or rights 

        (h)   Any and all amendments, extensions, renewals and extensions of any of the Copyrights, Patents or Trademarks; and 

        (i)    Any and all proceeds and products of the foregoing, including, without limitation, all payments under insurance or any
indemnity or warranty payable in respect of any of the foregoing. 

        Notwithstanding
the foregoing, nothing herein shall be deemed to prevent or prohibit Borrower from licensing its intellectual property to third parties in the ordinary course of business
or as set forth in Section 7.2 of the Loan Agreement. 

        It
shall be an Event of Default under the Loan Agreement if there is a breach of any term of this Negative Pledge Agreement.    Borrower agrees to properly execute all
documents reasonably required by Lender in order to fulfill the intent and purposes hereof. 

 

 

							
	 ANACOR PHARMACEUTICALS, INC.	 	Lighthouse Capital Partners V, L.P.
	
 By:	
 	

 	
 	
 By:	
 	
 LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner
	
 Name:	
 	
 Lucy O. Day

 	
 	
 By:	
 	
 

 
	
 Title:	
 	
 CFO

 	
 	
 Name:	
 	
 

 
	 	 	 	 	 Title:	 	

 

 

 1

 

 EXHIBIT I  

 CONTROL AGREEMENT  

[In
form and substance acceptable to Lender in its reasonable discretion] 

1

  Schedule 1  

 Disclosure Schedule  

 Deposit and Securities Accounts  

 

  

							
	 
	 	Account Information: 	 	Contact Information for

Account: 
	Account Number 1

(ACH Account)	 	 Bank Name:

Address:

City, State, Zip:

Phone:

Fax:

Type of Account:

Account number:	 	 Bank of America

530 Lytton Avenue

Palo Alto, CA 94301

650-853-4460

877-207-2708

Checking and Sweep	 	 Contact Name:

Phone:

Fax:

E-mail:
	
 Account Number 2

(To be closed within 120 days

of the date of the Agreement)	
 	
 Bank Name:

Address:

City, State, Zip:

Phone:

Fax:

Type of Account:

Account number:	
 	
 530 Lytton Avenue

Palo Alto, CA 94301

888-852-5000 x512

Checking	
 	
 Contact Name:

Phone:

Fax:

E-mail:
	
 Account Number 3

(To be closed within 120 days

of the date of the Agreement)	
 	
 Bank Name:

Address:

City, State, Zip:

Phone:

Fax:

Type of Account:

Account number:	
 	
 Bank of America Investment Services

530 Lytton Avenue

Palo Alto, CA 94301

650-853-4458

650-726-7983

Investment	
 	
 Contact Name:

Phone:

Fax:

E-mail:

 

 PERMITTED LIENS  

 

 

					
	EXISTING LIENS	 	 None	 	 

 

 SUBSIDIARIES  

None 

PRIOR NAMES  

Anamax, Inc. 

LITIGATION AND ADMINISTRATIVE PROCEEDINGS  

None 

BUSINESS PREMISES  

[TO BE PROVIDED BY BORROWER—indicate street address and landlord contact information] 

 

  

									
	 
	 	Each Location Address where Lighthouse

Capital Partners has financed assets: 	 	Landlord/Property Management Information: 
	Current

Headquarters

(Location 1)	 	 Contact Name:

Address:

City, State, Zip:

Phone:

Fax:	 	 Lucy Day

1060 E. Meadow Circle

Palo Alto, CA 94303

(650) 739-0700

(650) 739-0139	 	 Contact Name:

Company Name:

Address:

City, State, Zip:

Phone:

Fax:	 	

W.F. Batton Management Company

1000 C Commercial Street

San Carlos, CA 94070

(650) 591-8860

(650) 591-2650
	
 Location 2	
 	
 Contact Name:

Company Name:

Address:

City, State, Zip:

Phone:

Fax:	
 	
 	
 	
 Contact Name:

Company Name:

Address:

City, State, Zip:

Phone:

Fax:	
 	

 
	
 Location 3	
 	
 Contact Name:

Company Name:

Address:

City, State, Zip:

Phone:

Fax:	
 	
 	
 	
 Contact Name:

Company Name:

Address:

City, State, Zip:

Phone:

Fax:	
 	

 

 

 

 

  EXHIBIT I  

 (Account—With Activation)  

 DEPOSIT ACCOUNT CONTROL AGREEMENT  

        This Agreement is entered into as of June 30, 2006, among Anacor Pharmaceuticals ("Company"), Lighthouse Capital Partners
V, L.P. ("Lender"), and Bank of America, N.A. ("Bank") with respect to the following: 

        A.    Bank
has agreed to establish and maintain for Company deposit account number 1499419632 (the "Account"). 

        B.    Company
has assigned to Lender a security interest in the Account and in checks and other payment instructions ("Checks") deposited in the Account. 

        C.    Company,
Lender and Bank are entering into this Agreement to evidence Lender's security interest in the Account and such Checks and to provide for the disposition of net
proceeds of Checks deposited in the Account. 

 Accordingly, Company, Lender and Bank agree as follows: 

        1.     (a)    This
Agreement evidences Lender's control over the Account. Notwithstanding anything to the contrary in the agreement between Bank and Company governing
the Account, Bank will comply with instructions originated by Lender as set forth herein directing the disposition of funds in the Account without further consent of the Company. 

                (b)   Company
represents and warrants to Lender and Bank that it has not assigned or granted a security interest in the Account or any Check deposited in the
Account, except to Lender. 

                (c)   Company
will not permit the Account to become subject to any other pledge, assignment, lien, charge or encumbrance of any kind, other than Lender's
security interest referred to herein. 

                (d)   The
Account may receive merchant card deposits and chargebacks. Company acknowledges and agrees that during the Activation Period (defined below),
chargebacks will be blocked from debiting the Account. Company further acknowledges and agrees that, prior to the Activation Period, it will arrange with its merchant card vendor for chargebacks to be
directed towards an unblocked account. 

        2.     During
the Activation Period (as defined below), Bank shall prevent Company from making any withdrawals from the Account. Prior to the Activation Period, Company may
operate and transact business through the Account in its normal fashion, including making withdrawals from the Account, but covenants to Lender it will not close the Account. Bank shall have no
liability in the event Company breaches this covenant to Lender. 

        Company
and Lender acknowledge and agree that Bank may debit the Account for any ACH credit entries that may have been originated by Company but that have not settled at the time of
Bank's receipt of the Notice (defined below) or for any entries, whether credit or debit, that are subsequently returned thereafter. 

        A
reasonable period of time following the commencement of the Activation Period, and continuing on each Business Day thereafter, Bank shall transfer all collected and available balances
in the Account to Lender at its account specified in the Notice (as defined below). The "Activation Period" means the period which commences within a reasonable period of time not to exceed two
Business Days after Bank's receipt of a written notice from Lender in the form of Exhibit A (the "Notice"). A "Business Day" is each day except Saturdays, Sundays and Bank holidays. Funds are
not available if, in the 

1

 

reasonable
determination of Bank, they are subject to a hold, dispute or legal process preventing their withdrawal. 

        3.     Bank
agrees it shall not offset, charge, deduct or otherwise withdraw funds from the Account, except as permitted by Section 4, until it has been advised in
writing by Lender that all of Company's obligations that are secured by the Checks and the Account are paid in full. Lender shall notify Bank promptly in writing upon payment in full of Company's
obligations by means of a letter substantially in the form of the Termination Notice (defined below). 

        4.     Bank
is permitted to charge the Account: 

        (a)   for
its fees and charges relating to the Account or associated with this Agreement; and 

        (b)   in
the event any Check deposited into the Account is returned unpaid for any reason or for any breach of warranty claim. 

        5.     (a)    If
the balances in the Account are not sufficient to compensate Bank for any fees or charges due Bank in connection with the Account or this Agreement,
Company agrees to pay Bank on demand the amount due Bank. Company will have breached this Agreement if it has not paid Bank, within five days after such demand, the amount due Bank. 

                (b)   If
the balances in the Account are not sufficient to compensate Bank for any returned Check, Company agrees to pay Bank on demand the amount due Bank.
After Activation, if Company fails to so pay Bank immediately upon demand, Lender agrees to pay Bank within five days after Bank's demand to Lender to pay any amount received by Lender with respect to
such returned Check. The failure to so pay Bank shall constitute a breach of this Agreement. 

                (c)   Company
hereby authorizes Bank, without prior notice, from time to time to debit any other account Company may have with Bank for the amount or amounts due
Bank under subsection 5(a) or 5(b). 

        6.     (a)    Bank
will send information regarding deposits to the Account to the address specified below for Company or as otherwise specified in writing by Company
to Bank, and will send a copy of each such deposit advice to the address specified below for Lender. 

                (b)   In
addition to the original Bank statement provided to Company, Bank will provide Lender with a duplicate of such statement. 

        7.     (a)    Bank
will not be liable to Company or Lender for any expense, claim, loss, damage or cost ("Damages") arising out of or relating to its performance under
this Agreement other than those Damages which result directly from its acts or omissions constituting negligence or intentional misconduct. 

                (b)   In
no event will Bank be liable for any special, indirect, exemplary or consequential damages, including but not limited to lost profits. 

                (c)   Bank
will be excused from failing to act or delay in acting, and no such failure or delay shall constitute a breach of this Agreement or otherwise give
rise to any liability of Bank, if (i) such failure or delay is caused by circumstances beyond Bank's reasonable control, including but not limited to legal constraint, emergency conditions,
action or inaction of governmental, civil or military authority, fire, strike, lockout or other labor dispute, war, riot, theft, flood, earthquake or other natural disaster, breakdown of public or
private or common carrier communications or transmission facilities, equipment failure, or negligence or default of Company or Lender or (ii) such failure or delay resulted from Bank's
reasonable belief that the action would have violated any guideline, rule or regulation of any governmental authority. 

2

 

                (d)   Bank
shall have no duty to inquire or determine whether Company's obligations to Lender are in default or whether Lender is entitled to provide the Notice
to Bank. Bank may rely on notices and communications it believes in good faith to be genuine and given by the appropriate party. 

                (e)   Notwithstanding
any of the other provisions in this Agreement, in the event of the commencement of a case pursuant to Title 11, United States Code, filed
by or against Company, or in the event of the commencement of any similar case under then applicable federal or state law providing for the relief of debtors or the protection of creditors by or
against Company, Bank may act as Bank deems necessary to comply with all applicable provisions of governing statutes and shall not be in violation of this Agreement as a result. 

                (f)    Bank
shall be permitted to comply with any writ, levy order or other similar judicial or regulatory order or process concerning the Account or any Check
and shall not be in violation of this Agreement for so doing. 

        8.     Company
and Lender shall severally indemnify Bank against, and hold it harmless from, any and all liabilities, claims, costs, expenses and damages of any nature
(including but not limited to allocated costs of staff counsel, other reasonable attorney's fees and any fees and expenses) in any way arising out of or relating to disputes or legal actions
concerning Bank's provision of the services described in this Agreement to the extent such costs are incurred as a result of such party's actions or omissions. This section does not apply to any cost
or damage attributable to the gross negligence or intentional misconduct of Bank. Company's and Lender's obligations under this section shall survive termination of this Agreement. Except as
specifically provided herein, Lender shall not be liable for any amounts due Bank by Company hereunder. 

        9.     Company
and Lender shall severally pay to Bank, upon receipt of Bank's invoice, all costs, expenses and attorneys' fees (including allocated costs for
in-house legal services) incurred by Bank in connection with the enforcement of this Agreement and any instrument or agreement required hereunder, including but not limited to any such
costs, expenses and fees arising out of the resolution of any conflict, dispute, motion regarding entitlement to rights or rights of action, or other action to enforce Bank's rights in a case arising
under Title 11, United States Code to the extent such costs are incurred as a result of such party's actions or omissions. Company agrees to pay Bank, upon receipt of Bank's invoice, all costs,
expenses and attorneys' fees (including allocated costs for in-house legal services) incurred by Bank in the preparation and administration of this Agreement (including any amendments
hereto or instruments or agreements required hereunder). Except as specifically provided herein, Lender shall not be liable for any amounts due Bank by Company hereunder. 

        10.   Termination
and Assignment of this Agreement shall be as follows: 

        (a)   Lender
may terminate this Agreement by providing notice substantially in the form of Attachment I ("Termination Notice") to Company and Bank that all of Company's
obligations which are secured by Checks and the Account are paid in full. Lender may also terminate or it may assign this Agreement upon 30 day's prior written notice to Company and Bank. Bank
may terminate this Agreement upon 30 days' prior written notice to Company and Lender. Company may not terminate this Agreement except with the written consent of Lender and upon prior written
notice to Bank. 

        (b)   Notwithstanding
subsection 10(a), Bank may terminate this Agreement at any time by providing five days prior written notice to Company and Lender if either
Company or Lender breaches any of the terms of this Agreement, or any other agreement with Bank. 

        11.   (a)    Each
party represents and warrants to the other parties that (i) this Agreement constitutes its duly authorized, legal, valid, binding and
enforceable obligation; (ii) the performance of its obligations under this Agreement and the consummation of the transactions contemplated hereunder will not (A) constitute or result in
a breach of its certificate or articles of incorporation, 

3

 

by-laws
or partnership agreement, as applicable, or the provisions of any material contract to which it is a party or by which it is bound or (B) result in the violation of any law,
regulation, judgment, decree or governmental order applicable to it; and (iii) all approvals and authorizations required to permit the execution, delivery, performance and consummation of this
Agreement and the transactions contemplated hereunder have been obtained. 

                (b)   The
parties respectfully each agree that it shall be deemed to make and renew each representation and warranty in subsection 11(a) on and as of each
day on which Company, or the Lender, as the case may be, uses the services set forth in this Agreement. 

        12.   (a)    This
Agreement may be amended only by a writing signed by Company, Lender and Bank; except that Bank's charges are subject to change by Bank upon
30 days' prior written notice to Company. 

                (b)   This
Agreement may be executed in counterparts; all such counterparts shall constitute but one and the same agreement. 

                (c)   This
Agreement controls in the event of any conflict between this Agreement and any other document or written or oral statement among Bank, Company, and
Lender. This Agreement supersedes all prior understandings, writings, proposals, representations and communications, oral or written, of any party relating to the subject matter hereof. 

                (d)   This
Agreement shall be interpreted in accordance with California law without reference to that state's principles of conflicts of law. 

        13.   Any
written notice or other written communication to be given under this Agreement shall be addressed to each party at its address set forth on the signature page of
this Agreement or to such other address as a party may specify in writing. Except as otherwise expressly provided herein, any such notice shall be effective upon receipt. 

        14.   Nothing
contained in the Agreement shall create any agency, fiduciary, joint venture or partnership relationship between Bank and Company or Lender. Company and Lender
agree that nothing contained in this Agreement, nor any course of dealing among the parties to this Agreement, shall constitute a commitment or other obligation on the part of Bank to extend credit to
Company or Lender. 

4

 

        In
Witness Whereof, the parties hereto have executed this Agreement by their duly authorized officers as of the day and year first above written. 

 

 

					
	Anacor Pharmaceuticals, Inc.

("Company")	 	 
	
 By: /s/ LUCY O. DAY	
 	
  

 	
 	
Address for notices:
	Name: Lucy O. Day	 	 

 	 	1060 E. Meadow Circle
	Title: CFO	 	  

 	 	Palo Alto, CA 94303
	
Lighthouse Capital Partners V, L.P.

("Lender")	
 	

 
	

By: Lighthouse Management Partners V, L.L.C.,

its general partner	
 	

 
	
 By: /s/ THOMAS CONNEELY	
 	
 

 	
 	
Address for notices:
	Name: Thomas Conneely	 	  

 	 	500 Drakes Landing Road
	Title: Vice President	 	 

 	 	Greenbrae, CA 94904
	 	 	 	 	Attn: Contracts Administration
	
 Bank of America, N.A.

("Bank")
 	
 	

 	
 	

 

 

 

 

					
	By:	 	  

 	 	Address for notices:
	Name:	 	  

 	 	Bank of America, N. A.
	Title:	 	 

 	 	Deposit Support West
	 	 	 	 	Mail Code: WA1-501-21-01

P. O. Box 34414

Seattle, WA 98124
	

 	
 	
 	
 	
Telephone: 206-358-5180

Facsimile: 206-358-7792
	

 	
 	
 	
 	
and
	

 	
 	
 	
 	
Susan Oberto, VP

Bank of America NA

Deposit Support West

Mail Code: WA1-501-21-01

P. O. Box 34414

Seattle, WA 98124
	

 	
 	
 	
 	
Phone: 206.358.3490

Fax: 206.358.7792

 

 5

 
 
 EXHIBIT A

DEPOSIT ACCOUNT CONTROL AGREEMENT  

[Letterhead
of Lender] 

	
To:
	Bank
 of America, N.A.

[Address]

	Re:
	[Name
of Company]

Account No.                                     

Ladies
and Gentlemen: 

        Reference
is made to the Deposit Account Control Agreement
dated                                    (the "Agreement") among
[Company Name], us and you regarding the above-described
account (the "Account"). In accordance with Section 2 of the Agreement, we hereby give you notice of our exercise of control of the Account and we hereby instruct you to transfer funds to our
account as follows: 

 

 

					
	Bank Name:	 	 	 	 
	 	 	 	 	 
	Bank Address:	 	 	 	 
	 	 	 	 	 
	ABA No.:	 	 	 	 
	 	 	 	 	 
	Account Name:	 	 	 	 
	 	 	 	 	 
	Account No.:	 	 	 	 
	 	 	 	 	 
	Beneficiary's Name:	 	 	 	 
	 	 	 	 	 

 

  

 

 

					
	 
	 	Very truly yours,
	         
	 	 	 	 
	 	 	 
	 
	 	as Lender
	 
	 	 By:
	 	 
	 	 	 	 	 
	 
	 	Name:	 	 
	 	 	 	 	 
	 
	 	Title:	 	 
	 	 	 	 	 

 

 6

 
ATTACHMENT I

TERMINATION NOTICE  

Letterhead
of Secured Party 

                        ,
200       

Bank
of America, National Association

                                         
     

                                         
     

Attn:                                      

	Re:
	Termination of Deposit Account Control Agreement

Ladies
and Gentlemen: 

        Reference
is made to that certain                                    dated as
of                        , 200    (as amended, supplemented, amended and restated or otherwise modified from
time to time,
the "Agreement") among you,
                                    (the "Company"), and us as
('Lender"). You are hereby notified that the Agreement is terminated with respect
to the undersigned, and you have no further obligations to the undersigned thereunder. Notwithstanding any previous instructions to you, you are hereby instructed to accept all future directions with
respect to the Account from the Company. This notice terminates any obligations you may have to the undersigned with respect to the Account. 

 

 

					
	 
	 	Very truly yours,
	                 
	 	 	 	 
	 
	 	                                    

as Lender
	 
	 	 By:
	 	 
	 	 	 	 	 
	 
	 	 	 	Name:
	 
	 	 	 	Title:
	 
	 	  ACKNOWLEDGED AND AGREED:

	 
	 	  BANK OF AMERICA, NATIONAL ASSOCIATION, as Bank

	 
	 	By	 	 
	 	 	 	 	 
	 
	 	 	 	Name:
	 
	 	 	 	Title:

 

 7

  AMENDMENT NO. 01  

Dated February 26, 2008 

TO

that
certain Loan and Security Agreement No. 5251

dated as of June 30, 2006, ("Agreement"), by and between
 LIGHTHOUSE CAPITAL PARTNERS V, L.P. ("Lender")
and
 ANACOR PHARMACEUTICALS, INC. ("Borrower").

(All
capitalized terms not otherwise defined herein shall have the meanings given to such terms in the Agreement.) 

Without
limiting or amending any other provisions of the Loan Documents, Lender and Borrower agree to the following: 

	1.
	A
new Section 7.11 is hereby added to the Agreement to read in its entirety as follows: 

"The
Borrower will not hold any financial asset held as Collateral in the Account which is registered in the name of the Borrower, payable to the order of the Borrower or specially endorsed to the
Borrower (each such asset an "Identified Security"), except to the extent such Identified Security has been specially endorsed by the Borrower to the Securities Intermediary (currently Capital
Advisors Group) or in blank."  

	2.
	A
new Section 7.12 is hereby added to the Agreement to read in its entirety as follows: 

"The
Borrower will hold all Collateral in a domestic custodial system, as classified by Bloomberg, L.P." 

Except
as amended hereby, the Loan Documents remains unmodified and unchanged. 

 

 

							
	 BORROWER:	 	 LENDER:
	
 ANACOR PHARMACEUTICALS, INC.	
 	
 LIGHTHOUSE CAPITAL PARTNERS V, L.P.
	
By:	
 	
 /s/ LUCY O. DAY

 	
 	
 By:	
 	
 LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner
	
Name:	
 	
 Lucy O. Day

 	
 	
 By:	
 	
 /s/ THOMAS CONNEELY

 
	
Title:	
 	
 Director of Finance

 	
 	
 Name:	
 	
 Thomas Conneely

 
	

 	
 	

 	
 	
Title:	
 	
 Vice President

 

 

 

 
 AMENDMENT NO. 02 TO LOAN AND SECURITY AGREEMENT  

Dated
May 1, 2008 

        THIS AMENDMENT NO. 02 ("Amendment 02") to that certain Loan and Security
Agreement No. 5251 dated June 30, 2006, as amended by Amendment No. 01 (the "Agreement"; all capitalized terms not otherwise
defined herein are defined in the Agreement), is entered into as of May 1, 2008, by and between LIGHTHOUSE CAPITAL PARTNERS V, L.P.
("Lender") and ANACOR PHARMACEUTICALS, INC., a Delaware corporation
("Borrower"). 

        WHEREAS,
Borrower and Lender have previously entered into the Agreement; and 

        WHEREAS,
Borrower has requested Lender provide additional term loan financing in the amount of $7,000,000 and restructure the terms of its existing term loan financing with Lender; and 

        WHEREAS,
Lender has agreed to do so, subject to all of the terms and conditions hereof and of the Agreement; 

        NOW,
THEREFORE, in consideration of the foregoing and the mutual covenants herein contained, the parties hereby agree to modify the Agreement and to perform such other covenants and
conditions as follows: 

I.    Section 1.1, the following definitions shall be added to the Agreement: 

"Commitment Two" means $7,000,000. 

"Commitment Two Warrant" means the Warrant in favor of Lender to purchase securities of Borrower, substantially in the form of  Exhibit C-1 attached to
Amendment 02 and issued in conjunction with Commitment Two. 

II.    Section 1.1, each of the following definitions of the Agreement shall be deleted in its entirety and replaced with the
following: 

"Basic Rate" shall be defined in the Notes. 

"Commitment" means collectively (i) the Commitment prior to Amendment 02 and (ii) Commitment Two. 

"Commitment Fee" means (i) $10,000 in conjunction with the Commitment prior to Amendment 02, and (ii) $10,000 in conjunction with
Commitment Two. 

"Commitment Termination Date" has already occurred for Commitment One, and for Commitment Two, will occur on the Funding Date for Commitment Two in its
entirety, which shall occur on the date hereof. 

"Incumbency Certificate" means (i) the document in the form of Exhibit E of the Agreement
and (ii) in the form of Exhibit E-1 attached to Amendment 02. 

"Note" means (i) an Amended and Restated Secured Promissory Note in the form of  Exhibit B-1 attached to this Agreement for Advances funded under the
Commitment prior to this Amendment; and (ii) for Advances
under Commitment Two, a Secured Promissory Note in the form of Exhibit B-2 attached to Amendment 02. 

"Notice of Borrowing" means (i) the document in the form of Exhibit D of the Agreement and
(ii) for Advances under Commitment Two, in the form of Exhibit D-1 attached to Amendment 02. 

"Permitted Indebtedness" means: (i) the Loan; (ii) unsecured trade debt incurred in the ordinary course of Borrower's business;
(iii) Indebtedness secured by clause (ii) of Permitted Liens; (iii) Subordinated Debt; (iv) insurance premiums provided such premiums are secured solely by the
relevant policies, and (v) other Indebtedness up to a maximum amount of $100,000 in the aggregate in any fiscal year. 

1

 

"Warrant" means the (i) the Preferred Stock Purchase Warrant in favor of Lender and its affiliates to purchase securities of Borrower effective
as of June 30, 2006 to be issued in accordance with Section 6.8 hereof and (ii) the Commitment Two Warrant. 

III.    Section 3, Conditions of Advances; Procedure for requesting Advances

The
following new Section 3.3 and Section 3.4 shall be added to the Agreement: 

3.3    Conditions Precedent to Initial Advance under Commitment Two:  

        The obligation of Lender to make any Advances pursuant to Commitment Two is subject to each and every one of the following conditions precedent in form and
substance satisfactory to Lender in its sole reasonable discretion: 

        (a)   This Amendment 02 duly executed by Borrower. 

        (b)   The Commitment Two Warrant has been issued to Lender duly executed by Borrower. 

        (c)   An officer's certificate of Borrower with copies of the following documents attached:  (i) the certificate of incorporation and by-laws or
other organizational documents of Borrower certified by Borrower as being in full
force and effect as of the Amendment, (ii) incumbency and representative signatures, and  (iii) resolutions authorizing the execution and delivery
of Amendment 02 and any other Loan Documents. 

        (d)   Without limiting the foregoing or Lender's rights or Borrower's obligations under the Agreement, such consents,
amendments, filings, recordations, or other documents from any persons or entities necessary to maintain the perfection and priority of Lender's security interest in the Collateral, in form and
substance satisfactory to Lender in its sole discretion. 

        (e)   A good standing certificate from Borrower's state of incorporation or formation and the state in which Borrower's
principal place of business is located, together with certificates of the applicable governmental authorities stating that Borrower is in compliance with the franchise tax laws of each such state,
each dated as of a recent date. 

        (f)    All necessary consents of shareholders, members, and other third parties with respect to the execution, delivery and
performance of the Agreement, Amendment 02, the Commitment Two Warrant, and any other Loan Documents. 

        (g)   Borrower shall have satisfied all the conditions, other than the requirement to provide Lender written notice at least
ten (10) days prior to the Advance contemplated in Section 3.3(h) of this Amendment 02, set forth in Section 3.1 and  3.2 of this
Agreement. 

        (h)   Borrower shall have executed a Note for an Advance under Commitment Two of $7,000,000. 

3.4    Reaffirmation    Except as specifically provided otherwise in the amended Disclosure Schedule dated the date of
Amendment 02, Borrower reaffirms as of the date of Amendment 02 and after giving effect thereto the representations and warranties made to Lender in the Agreement as though fully set
forth herein. 

IV.    Section 6, Affirmative Covenants

Section 6.2 shall be amended and replaced with the following: 

        6.2    Financial Statements, Reports, Certificates.    Prior to a Public Offering (as defined below), Borrower shall
deliver to Lender: (i) as soon as prepared, and no later than 30 days after the end of each calendar month, a balance sheet and an income
statement covering Borrower's operations during such period; (ii) as soon as prepared, and no later than 30 days after the end of each
calendar quarter, a cash flow statement covering Borrower's operations during such period; (iii) as soon as prepared, but 

2

 

no
later than 180 days after the end of the fiscal year, audited financial statements prepared in accordance with GAAP, together with an opinion that such financial statements fairly present
Borrower's financial condition by an independent public accounting firm reasonably acceptable to Lender; (iv) promptly upon notice thereof, a report of
any legal or administrative action pending or threatened against Borrower which is likely to result in liability to Borrower in excess of $50,000; and  (v) such other financial information as Lender may
reasonably request from time to time. Following the commencement of sale of Borrower's Common Stock
to the public in a public offering pursuant to a Registration Statement under the 1933 Act (a "Public Offering"), and the declaration of effectiveness
of the related Registration Statement by the Securities and Exchange Commission ("SEC"), Borrower agrees to make available quarterly and annual
financial statements in accordance with SEC requirements. 

V.    Section 11, Notices

Section 11 shall be amended and replaced with the following: 

 11. NOTICES  

        All notices shall be in writing and personally delivered or sent by certified mail, postage prepaid, return receipt requested, or by
confirmed facsimile, at the respective addresses set forth below: 

 

 

			
	If to Borrower:	 	 If to Lender:
	
Anacor Pharmaceuticals, Inc.

1020 E. Meadow Circle

Palo Alto, California 94303

Attention: Chief Financial Officer

FAX: (650) 543-7661	
 	
 Lighthouse Capital Partners V, LP

500 Drake's Landing Road

Greenbrae, California 94904

Attention: Contract Administrator

FAX: (415) 925-3387
	
With a copy to Borrower's Counsel:	
 	

 
	
Mark B. Weeks

Heller Ehrman LLP

275 Middlefield Road

Menlo Park, CA 94025-3506

FAX: (650) 324-0638	
 	

 

 

 VI.    Additional Terms and Conditions

        (a)    Further Conditions.    The following are conditions precedent to Lender's obligations hereunder, without
delivery and performance of which to Lender's satisfaction, the original payment terms of the Loan Documents and the Notes shall remain in full force and effect, unamended hereby, and Commitment Two
will be automatically cancelled: 

          (i)  Borrower
shall execute and deliver the Amended and Restated Note in the form attached hereto as  Exhibit B-1. 

         (ii)  Borrower
shall deliver an Incumbency Certificate, certified by responsible officers of Borrower in the form attached hereto as  Exhibit E-1, and attachments thereto including the resolutions adopted
by Borrower's board of directors authorizing the execution and
delivery of this Amendment 02
and the other documents referred to in this Amendment and the performance by Borrower of its obligations under such documents. 

        (iii)  Borrower
shall execute and deliver all other documents, as Lender shall have reasonably requested prior to the execution by Borrower and Lender of Amendment 02. 

3

 

        (iv)  Borrower
shall pay all Lender's Expenses for the preparation and negotiation of documents associated with this Amendment 02. 

        (b)    Representations and Warranties of Borrower.    Except as set forth in the Disclosure Schedule, Borrower
warrants and represents, as a significant material inducement to Lender to enter hereinto, that: (i) no Events of Default have occurred that have not been disclosed to Lender by Borrower in
writing; (ii) it has not reached any settlement with any other creditor of Borrower that has not been disclosed in writing to Lender; (iii) it is not and has no reason to believe it may
be named as a party to any judicial or administrative proceeding, litigation or arbitration, and has not received any written communication from any person or entity (whether private or governmental)
threatening or indicating the same; (iv) it is in full compliance with Section 7.10 of the Agreement; (v) Lender has made no separate oral or written waiver of any existing or
future Default or Event of Default by Borrower under any Loan Document; (vi) neither Borrower, nor any subsidiary or affiliate of Borrower, has any claims or rights of set-off
against Lender of any kind under any Loan Document or otherwise; and (vii) Borrower has no defenses to payments of any amounts owed to Lender as the same become due and payable. 

        (c)    No Control.    Borrower warrants and represents, as a significant material inducement to Lender to enter
hereinto, that none of Lender nor any affiliate, officer, director, employee, agent, or attorney of Lender, have at any time, from Borrower's date of formation through to the date hereof,
(i) exercised management or other control over the Borrower, (ii) exercised undue influence over Borrower or any of its officers, employees or directors, (iii) made any
representation or warranty, express or implied, to any party on behalf of Borrower, (iv) entered into any joint venture, agency relationship, employment relationship, or partnership with
Borrower, (v) directed or instructed Borrower on the manner, method, amount, or identity of payee of any payment made to any creditor of Borrower, and further, Borrower warrants and represents
that by entering hereinto with Lender have not, are not and will not have engaged in any of the foregoing. 

VII.    Integration Clause.    This Amendment 02 represents and documents the entirety of the agreement and understanding of
the parties hereto with respect to its subject matter. All prior understandings, whether oral or written, other than the Loan Documents, are hereby merged hereinto. NONE OF THE
AGREEMENT OR THIS AMENDMENT 02 MAY BE MODIFIED EXCEPT BY A WRITING SIGNED BY LENDER AND BORROWER. Each provision hereof shall be severable from every other provision
when determining its legal enforceability such that Lender's rights and remedies under Amendment 02 and the Agreement may be enforced to the maximum extent permitted under applicable law. This
Amendment 02 shall be binding upon, and inure to the benefit of, each party's respective permitted successors and assigns. This Amendment 02 may be executed in counterpart originals, all
of which, when taken together, shall constitute one and the same original document. No provision of any other document between Lender and Borrower shall limit the effectiveness hereof or the rights
and remedies of Lender against Borrower. In the event of any contradiction or inconsistency among the terms and conditions of this Amendment 02 or the Agreement the interpretation most
favorable to the interests of Lender shall prevail. 

4

 

Except
as amended hereby, the Agreement remains unmodified and unchanged. 

 

 

							
	 BORROWER:	 	 LENDER:
	
 ANACOR PHARMACEUTICALS, INC.	
 	
 LIGHTHOUSE CAPITAL PARTNERS V, L.P.
	
By:	
 	
 /s/ CHRISTINE GRAY-SMITH

 	
 	
 By:	
 	
 LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner
	
Name:	
 	
 Christine Gray-Smith

 	
 	
 By:	
 	
 /s/ THOMAS CONNEELY

 
	
Title:	
 	
 Senior Vice President,

Chief Financial Officer

 	
 	
 Name:	
 	
 Thomas Conneely

 
	 	 	 	 	Title:	 	 Vice President

 

 

 ATTACHMENTS:  

Exhibit B-1—Amended
and Restated Secured Promissory Note

Exhibit B-2—Commitment Two Secured Promissory Note

Exhibit C-2—Commitment Two Warrant

Exhibit D-1—Notice of Borrowing

Exhibit E-1—Incumbency Certificate

Schedule 1—Disclosure Schedule 

5

 

 EXHIBIT B-1  

 AMENDED AND RESTATED SECURED PROMISSORY NOTE  

(originally issued in the amount of $8,000,000 on July 10, 2006) 

$7,280,353.44  

SECURED PROMISSORY NOTE  

This  SECURED PROMISSORY NOTE (this "Note") is made April 1, 2008, by  ANACOR PHARMACEUTICALS,
 INC. ("Borrower") in favor of LIGHTHOUSE CAPITAL
PARTNERS V, L.P. (collectively with its assigns, "Lender"). Initially capitalized terms used and not otherwise defined
herein are defined in that certain Loan and Security Agreement No. 5251 between Borrower and Lender dated June 30, 2006 (the "Loan
Agreement"), and amends and restates, but does not replace or novate, those Notes executed prior to April 1, 2008. 

FOR VALUE RECEIVED, Borrower promises to pay in lawful money of the United States, to the order of Lender, at 500 Drake's Landing Road, Greenbrae,
California 94904, or such other place as Lender may from time to time designate ("Lender's Office"), the principal sum of $7,280,353.44 (the
"Advance"), including interest on the unpaid balance and all other amounts due or to become due hereunder according to the terms hereof and of the Loan
Agreement. 

"Basic Rate" means (i) during the Interest Only Period, a fixed per annum rate of interest equal
to 9.75% and (ii) on and after the Loan Commencement Date, a fixed per annum rate of interest equal to 9.25%. 

"Final Payment" means 9.5% of the Advance. 

"Forbearance Fee" means $285,000, due on the Maturity Date. 

"Interest Only Period" means the period commencing on the date hereof and continuing until the Loan Commencement Date. 

"Loan Commencement Date" means May 1, 2009. 

"Maturity Date" means the last day of the Repayment Period, or if earlier, the date of prepayment under the Note. 

"Payment Date" means the first day of each calendar month. 

"Prepayment Fee" means (i) 3% of the outstanding principal amount being prepaid if such prepayment is
made in calendar year 2006 or 2007; (ii) 2% of the outstanding principal amount being prepaid if such prepayment is made in calendar year 2008, or  (iii) 1%
of the outstanding principal amount being prepaid if such prepayment is made in calendar year 2009 or thereafter. 

"Repayment Period" means the period beginning on the Loan Commencement Date and continuing for 24 calendar months. 

1.    Repayment.    Borrower shall pay principal and interest due hereunder from the
Funding Date, until this Note is paid in full, on each Payment Date pursuant to the terms of the Loan Agreement and this Note. Prior to the Loan Commencement Date, Borrower shall pay to Lender,
monthly in advance on each Payment Date, interest calculated using the Basic Rate. Beginning on the Loan Commencement Date and on each Payment Date thereafter during the Repayment Period, Borrower
shall make equal installments of principal and interest in advance, calculated at the Basic Rate. On the Maturity Date, Borrower shall pay, in addition to all unpaid principal and interest outstanding
hereunder, the Final Payment and the Forbearance Fee. 

2.    Interest.    Interest not paid when due will, to the maximum extent permitted
under applicable law, become part of principal, at Lender's option, and thereafter bear like interest as principal. All interest 

1

 

computation
shall be based on a 360-day year and actual days elapsed. All Obligations not paid when due shall bear interest at the Default Rate unless waived in writing by Lender. All
amounts paid hereunder will be applied to the Obligations in Lender's discretion and as provided in the Loan Agreement. 

3.    Voluntary Prepayment.    Borrower may prepay the Note if and only if Borrower
pays to Lender (i) the outstanding principal amount of this Note and any unpaid accrued interest; (ii) the Final Payment; (iii) the Prepayment Fee; (iv) the Forbearance
Fee, and (v) all other sums, if any, that shall have become due and payable hereunder with respect to this Note. 

4.    Collateral.    This Note is secured by the Collateral. 

5.    Waivers.    Borrower, and all guarantors and endorsers of this Note,
regardless of the time, order or place of signing, hereby waive notice, demand, presentment, protest, and notices of every kind, presentment for the purpose of accelerating maturity, diligence in
collection, and, to the fullest extent permitted by law, all rights to plead any statute of limitations as a defense to any action on this Note. 

6.    Choice of Law; Venue.    THIS NOTE SHALL BE GOVERNED
BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE
JURISDICTION AND VENUE OF THE STATE AND FEDERAL COURTS LOCATED IN THE CITY AND COUNTY OF SAN FRANCISCO, STATE OF CALIFORNIA. BORROWER AND LENDER EACH HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY
TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS NOTE. EACH PARTY FURTHER WAIVES ANY RIGHT TO CONSOLIDATE ANY ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER ACTION
IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.

7.    Miscellaneous.    THIS NOTE MAY BE MODIFIED ONLY BY A
WRITING SIGNED BY BORROWER AND LENDER. Each provision hereof is severable from every other provision hereof and of the Loan Agreement when determining its legal enforceability.
Sections and subsections are titled for convenience, and not for construction. "Hereof," "herein," "hereunder," and similar words refer to this Note in its entirety. "Or" is not necessarily exclusive.
"Including" is not limiting. The terms and conditions hereof inure to the benefit of and are binding upon the parties' respective permitted successors and assigns. This Note is subject to all the
terms and conditions of the Loan Agreement. 

IN WITNESS WHEREOF, Borrower has caused this Note to be executed by a duly authorized officer as of the day and year first above written. 

 

 

					
	 	 	ANACOR PHARMACEUTICALS, INC.
	

 	
 	
  By:	
 	

 
	

 	
 	
Name:	
 	
Christine Gray-Smith

 
	

 	
 	
Title:	
 	
Senior Vice President, Chief Financial Officer

 

 

 2

 

 EXHIBIT B-2

COMMITMENT TWO SECURED PROMISSORY NOTE  

 $7,000,000.00  

SECURED PROMISSORY NOTE  

This  SECURED PROMISSORY NOTE (this "Note") is made May 1, 2008, by ANACOR
PHARMACEUTICALS, INC. ("Borrower") in favor of LIGHTHOUSE CAPITAL PARTNERS
V, L.P. (collectively with its assigns, "Lender"). Initially capitalized terms used and not otherwise defined herein are
defined in that certain Loan and Security Agreement No. 5251 between Borrower and Lender dated June 30, 2006 (the "Loan Agreement"). 

FOR VALUE RECEIVED, Borrower promises to pay in lawful money of the United States, to the order of Lender, at 500 Drake's Landing Road, Greenbrae,
California 94904, or such other place as Lender may from time to time designate ("Lender's Office"), the principal sum of $7,000,000.00 (the
"Advance"), including interest on the unpaid balance and all other amounts due or to become due hereunder according to the terms hereof and of the Loan
Agreement. 

"Basic Rate" means (i) during the Interest Only Period, a fixed per annum rate of interest equal
to 12.00% and (ii) on and after the Loan Commencement Date, a fixed per annum rate of interest equal to 9.25%. 

"Final Payment" means 5.85% of the Advance. 

"Interest Only Period" means the period commencing on the date hereof and continuing until the Loan Commencement Date. 

"Loan Commencement Date" means May 1, 2009. 

"Maturity Date" means the last day of the Repayment Period, or if earlier, the date of prepayment in full under the Note. 

"Payment Date" means the first day of each calendar month. 

"Prepayment Fee" means (i) 3% of the outstanding principal amount, in excess of $3,500,000, being
prepaid if such prepayment is made on or prior to March 31, 2009; (ii) 2% of the outstanding principal amount being prepaid if such prepayment is
made between April 1, 2009 and March 31, 2010, or (iii) 1% of the outstanding principal amount being prepaid if such prepayment is made
after March 31, 2010. 

"Repayment Period" means the period beginning on the Loan Commencement Date and continuing for 24 calendar months. 

1.    Repayment.    Borrower shall pay principal and interest due hereunder from the
Funding Date, until this Note is paid in full, on each Payment Date pursuant to the terms of the Loan Agreement and this Note. Prior to the Loan Commencement Date, Borrower shall pay to Lender,
monthly in advance on each Payment Date, interest calculated using the Basic Rate. Beginning on the Loan Commencement Date and on each Payment Date thereafter during the Repayment Period, Borrower
shall make equal installments of principal and interest in advance, calculated at the Basic Rate. On the Maturity Date, Borrower shall pay, in addition to all unpaid principal and interest outstanding
hereunder, the Final Payment. 

2.    Interest.    Interest not paid when due will, to the maximum extent permitted
under applicable law, become part of principal, at Lender's option, and thereafter bear like interest as principal. All interest computation shall be based on a 360-day year and actual
days elapsed. All Obligations not paid when due shall bear interest at the Default Rate unless waived in writing by Lender. All amounts paid 

1

 

hereunder
will be applied to the Obligations in Lender's discretion and as provided in the Loan Agreement. 

3.    Voluntary Prepayment.    Subject to  Section 4, Borrower may prepay the Note if
and only if Borrower pays to Lender (i) the outstanding principal amount of this Note and any
unpaid accrued interest; (ii) the Final Payment; (iii) the Prepayment Fee; and (iv) all other sums, if any, that shall have become due and payable hereunder with respect to this
Note. 

4.    Early Prepayment Option.    On or before March 31, 2009, Borrower may
prepay up to $3,500,000 of the principal balance (the "Early Prepayment Option") if and only if Borrower pays to Lender (i) up to $3,500,000 plus
any unpaid accrued interest; and (ii) and all other sums, if any, that shall have become due and payable hereunder with respect thereto. In the event the Early Prepayment Option is exercised,
the Prepayment Fee shall be waived and the Final Payment due on account of the funds paid pursuant to the exercise of the Early Prepayment Option shall be paid on the Maturity Date. 

5.    Collateral.    This Note is secured by the Collateral. 

6.    Waivers.    Borrower, and all guarantors and endorsers of this Note,
regardless of the time, order or place of signing, hereby waive notice, demand, presentment, protest, and notices of every kind, presentment for the purpose of accelerating maturity, diligence in
collection, and, to the fullest extent permitted by law, all rights to plead any statute of limitations as a defense to any action on this Note. 

7.    Choice of Law; Venue.    THIS NOTE SHALL BE GOVERNED
BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE
JURISDICTION AND VENUE OF THE STATE AND FEDERAL COURTS LOCATED IN THE CITY AND COUNTY OF SAN FRANCISCO, STATE OF CALIFORNIA. BORROWER AND LENDER EACH HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY
TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS NOTE. EACH PARTY FURTHER WAIVES ANY RIGHT TO CONSOLIDATE ANY ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER ACTION
IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.

8.    Miscellaneous.    THIS NOTE MAY BE MODIFIED ONLY BY A
WRITING SIGNED BY BORROWER AND LENDER. Each provision hereof is severable from every other provision hereof and of the Loan Agreement when determining its legal enforceability.
Sections and subsections are titled for convenience, and not for construction. "Hereof," "herein," "hereunder," and similar words refer to this Note in its entirety. "Or" is not necessarily exclusive.
"Including" is not limiting. The terms and conditions hereof inure to the benefit of and are binding upon the parties' respective permitted successors and assigns. This Note is subject to all the
terms and conditions of the Loan Agreement. 

IN WITNESS WHEREOF, Borrower has caused this Note to be executed by a duly authorized officer as of the day and year first above written. 

 

 

					
	 	 	ANACOR PHARMACEUTICALS, INC.
	

 	
 	
  By:	
 	

 
	

 	
 	
Name:	
 	
Christine Gray-Smith

 
	

 	
 	
Title:	
 	
Senior Vice President, Chief Financial Officer

 

 

 2

 

 EXHIBIT C-1

COMMITMENT TWO WARRANT

1

 

 EXHIBIT D-1

NOTICE OF BORROWING  

                                    ,
                       

Lighthouse
Capital Partners V, L.P.

500 Drake's Landing Road

Greenbrae, CA 94904-3011

Ladies and Gentlemen: 

        Reference
is made to the Loan and Security Agreement No. 5251 dated as of June 30, 2006 (as it has been and may be amended from time to time, the
"Loan Agreement," initially capitalized terms used herein as defined therein), between LIGHTHOUSE CAPITAL PARTNERS
V, L.P. and ANACOR PHARMACEUTICALS, INC. (the "Company") 

        The
undersigned is the [Chief Financial Officer/President and CEO] of the Company, and hereby irrevocably requests an Advance under the Loan Agreement, and in
that connection certifies as follows: 

        1.     The
amount of the proposed Advance is $7,000,000. The business day of the proposed Advance is May 1, 2008. 

        2.     The
Loan Commencement Date for this Advance shall be May 1, 2009. 

        3.     As
of this date, no Default or Event of Default, has occurred and is continuing, or will result from the making of the proposed Advance, and the representations and
warranties of the Company contained in Section 5 of the Loan Agreement are true and correct in all material respects, except as set forth in the
Disclosure Schedule and any updates thereto delivered on or before the date hereof. 

        4.     No
event that could reasonably be expected to have a material adverse effect on the ability of Borrower to fulfill its obligations under the Loan Agreement has occurred
since the date of the most recent financial statements, submitted to you by the Company. 

        The
Company agrees to notify you promptly before the funding of the Advance if any of the matters to which I have certified above shall not be true and correct on the Funding Date. 

 

 

					
	 	 	Very truly yours,
	

 	
 	
 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	
 

 
	

 	
 	
Name:	
 	
Christine Gray-Smith

 
	

 	
 	
Title:	
 	
Senior Vice President, Chief Financial Officer

 

 

 1

 

 EXHIBIT E-1

INCUMBENCY CERTIFICATE  

        The undersigned, Christine Gray-Smith, hereby certifies that: 

1.    He/She is the duly elected and acting Senior Vice President and Chief Financial Officer of ANACOR
PHARMACEUTICALS, INC., a Delaware corporation (the "Company"). 

2.    That on the date hereof, each person listed below holds the office in the Company indicated opposite his or her name and that the
signature appearing thereon is the genuine signature of each such person: 

 

 

					
	NAME

 
	 	OFFICE

 
	 	SIGNATURE

 

	David Perry	 	President and Chief Executive Officer	 	 

 
	
 Christine Gray-Smith	
 	
Senior Vice President, Chief Financial Officer	
 	
  

 

 

 3.    Attached hereto as Exhibit A is a true and correct copy of the Certificate of
Incorporation of the Company, as amended, as in effect as of the date hereof. 

4.    Attached hereto as Exhibit B is a true and correct copy of the Bylaws of the
Company, as amended, as in effect as of the date hereof. 

5.    Attached hereto as Exhibit C is a copy of the resolutions of the Board of
Directors of the Company authorizing and approving the Company's execution, delivery and performance of a loan facility with Lighthouse Capital Partners V, L.P. 

        IN
WITNESS WHEREOF, the undersigned has executed this Incumbency Certificate on May             , 2008. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	
 

 
	

 	
 	
Name:	
 	
Christine Gray-Smith

 
	

 	
 	
Title:	
 	
Senior Vice President, Chief Financial Officer

 

 

         I,
the Chief Executive Officer of the Company, do hereby certify that Christine Gray-Smith is the duly qualified, elected and acting Senior Vice President and Chief Financial
Officer of the Company and that the above signature is his or her genuine signature. 

        IN
WITNESS WHEREOF, the undersigned has executed and delivered this Incumbency Certificate on May             , 2008. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	
 

 
	

 	
 	
Name:	
 	
David Perry

 
	

 	
 	
Title:	
 	
President and Chief Executive Officer

 

 

 1

 

 SCHEDULE 1

DISCLOSURE SCHEDULE

DEPOSIT AND SECURITIES ACCOUNTS  

 

 

					
	 
	 	Account Information: 	 	Contact Information for

Account: 
	Account

Number

1

(ACH

Account)	 	 Bank Name: Bank of America

Address: 530 Lytton Avenue

City, State, Zip: Palo Alto, CA 94301

Phone: 650-853-4460

Fax: 877-207-2708

Type of Account: Checking and Sweep

Account number: 14994-19632	 	 Contact Name: Katherine Wada

Phone: 650-853-4460

Fax: 877-207-2708

E-mail: Katherine.s.wada@bankofamerica.com
	
Account

Number

2	
 	
 Bank Name: State Street Bank

Address: 225 Franklin Street

City, State, Zip: Boston, MA 02110

Phone: 617-537-3007

Fax:

Type of Account: Custodial

Account number: DE3165	
 	
 Contact Name: Jim Hall, AVP

Phone: 617-537-3007

Fax: 617-537-3925

E-mail: jshall@statestreet.com

 

 PERMITTED LIENS
(see "Existing Liens" below)

Existing Liens  

	1.
	Lighthouse Capital Partners V., L.P., in connection with Loan and Security Agreement No. 5251  
	2.
	 Liens in
favor of AICCO or other lender to secure the payment of insurance premiums   
	3.
	 CD-secured standby letters of credit issued by Bank of America to Borrower's landlords in the aggregate amount of $254,000  

SUBSIDIARIES
None
  PRIOR NAMES
  Anamax, inc.
  LITIGATION AND ADMINISTRATIVE PROCEEDINGS

1

 

EEOC claim by former temporary employee made in December 2007 alleging unfair hiring practices. The Borrower filed a response denying the allegations on March 19, 2008,
and has had no further communication from the EEOC.

BUSINESS PREMISES  

 

 

					
	 
	 	Each Location Address where Lighthouse

Capital Partners has financed assets: 	 	Landlord/Property Management

Information: 
	Current HQ

(Location 1)	 	 Contact Name: Lucy Day

Address: 1020 E. Meadow Circle

City, State, Zip: Palo Alto, CA 94303

Phone: (650) 543-7500

Fax: (650) 543-7660	 	 Contact Name: Nancy Merwyn

Company Name: California Pacific Commercial Corporation

Address: 2200 Sand Hill Road, #230

City, State, Zip: Menlo Park, CA 94025

Phone: 650-854-5104

Fax: 650-854-8867
	
Other Facility

(Location 2)	
 	
 Contact Name: Lucy Day

Address: 1060 E. Meadow Circle

City, State, Zip: Palo Alto, CA 94303

Phone: (650) 543-7500

Fax: (650) 543-7660	
 	
 Contact Name: Harold Balzer

Company Name: W.F. Batton Management Company

Address: 1000 C Commercial Street

City, State, Zip: San Carlos, CA 94070

Phone: (650) 591-8860

Fax: (650) 591-2650

 

 2

 

   AMENDMENT NO. 03 TO LOAN AND SECURITY AGREEMENT  

        This AMENDMENT NO. 03 to Loan and Security Agreement (this "Amendment 03") is entered
into as of January 23, 2010, by and between LIGHTHOUSE CAPITAL PARTNERS V, L.P.
("Lender") and ANACOR PHARMACEUTICALS, INC., a Delaware corporation
("Borrower"), with reference to the following: 

 RECITALS  

        WHEREAS, Borrower and Lender have previously entered into that certain Loan and Security Agreement No. 5251 dated as of
June 30, 2006, as amended, (the "Loan and Security Agreement"; all initially capitalized terms not otherwise defined herein shall have the
meanings given to such terms in the Loan and Security Agreement), together with the other agreements and instruments entered into in connection therewith (collectively, the
"Loan Documents" and individually a "Loan Document"); and 

        WHEREAS,
Borrower has requested that Lender restructure the terms of the Loan and Security Agreement; and 

        WHEREAS,
Lender has agreed to do so, subject to all of the terms and conditions hereof and of the Agreement; 

        NOW,
THEREFORE, in consideration of the foregoing and the mutual covenants herein contained, the parties hereby agree to modify the Agreement and to perform such other covenants and
conditions as follows: 

I.    Section 1.1, the following definitions shall be added to the Agreement: 

"Interest Only Period" means the period commencing on January 1, 2010 and ending on the Interest Only Period Maturity Date. 

"Interest Only Period Maturity Date" means the earlier of (i) June 30, 2010, or (ii) the last day of the month following the first
to occur of either (a) Borrower's receipt of a $15 million milestone payment from GSK or (b) Borrower's receipt of an upfront fee of at least $15 million from a new
licensing agreement for its AN2690 compound. 

"Modification Warrant" means the Warrant in favor of Lender to purchase securities of Borrower, substantially in the form of  Exhibit C-3 attached to
Amendment 03. 

"Second Forbearance Fee" means $225,000 plus $37,500 for each month of the Interest Only Period, or
portion thereof, to a maximum of $450,000, due and payable on the first business day following the Interest Only Period Maturity Date. 

II.    Section 1.1, the following definition in the Loan and Security Agreement shall be deleted in its entirety and replaced with the
following: 

"Warrant" means the (i) the Preferred Stock Purchase Warrant in favor of Lender and its affiliates to purchase securities of Borrower effective
as of June 30, 2006 to be issued in accordance with Section 6.8 hereof, (ii) the Commitment Two Warrant, and (iii) the
Modification Warrant. 

Section 11. Notices, the following name and address of the Borrower's Counsel shall be deleted in its entirety and replaced with the following:

Mark B. Weeks

Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306-2155

Fax: (650) 857-0663
  

1

 

III.    Amendment and Restatement of the Amended and Restated Note.  

The Amended and Restated Secured Promissory Note dated April 1, 2008 and the Secured Promissory Note dated May 1, 2008 shall both be further amended and restated
with a note in the form attached hereto as Exhibit B-3 (the "Second Amended and Restated Secured Promissory
Note"). 

VI.    Additional Terms and Conditions.  

1.    Further Conditions.    The following are conditions precedent to Lender's obligations hereunder,
without delivery and performance of which to Lender's satisfaction, the original payment terms of the Loan Documents and the Amended and Restated Note dated April 1, 2008 and the Secured
Promissory Note dated May 1, 2008 shall remain in full force and effect, unamended hereby: 

          (i)  Borrower
shall execute and deliver the Amended and Restated Note in the form attached hereto as  Exhibit B-3. 

         (ii)  Borrower
shall execute and deliver the Modification Warrant in the form attached hereto as  Exhibit C-3. 

        (iii)  Borrower
shall pay all Lenders' Expenses for the preparation and negotiation of documents associated with this Amendment 03. 

2.    Representations and Warranties of Borrower.    Borrower warrants and represents, as a significant material inducement to
Lender to enter hereinto, that: (i) no Events of Default have occurred and are continuing that have not been disclosed to Lender by Borrower in writing; (ii) it is not and has no reason
to believe it may be named as a party to any judicial or administrative proceeding, litigation or arbitration, and has not received any written communication from any person or entity (whether private
or governmental) threatening or indicating the same; and (iii) it is in all material respects in compliance with the Loan and Security Agreement (iv) it is in full compliance with
Section 7.10 of the Agreement; (v) Lender has made no separate oral or written waiver of any existing or future Default or Event of Default by Borrower under any Loan Document;
(vi) neither Borrower, nor any subsidiary or affiliate of Borrower, has any claims or rights of set-off against Lender of any kind under any Loan Document or otherwise; and
(vii) Borrower has no defenses to payments of any amounts owed to Lender as the same become due and payable. 

3.    No Control.    Borrower warrants and represents, as a significant material inducement to Lender to enter hereinto, that none
of Lender nor any affiliate, officer, director, employee, agent, or attorney of Lender, have at any time, from Borrower's date of formation through to the date hereof, (i) exercised management
or other control over the Borrower, (ii) exercised undue influence over Borrower or any of its officers, employees or directors, (iii) made any representation or warranty, express or
implied, to any party on behalf of Borrower, (iv) entered into any joint venture, agency relationship, employment relationship, or partnership with Borrower, (v) directed or instructed
Borrower on the manner, method, amount, or identity of payee of any payment made to any creditor of Borrower, and further, Borrower warrants and represents that by entering hereinto, Lender has not,
is not and will not have engaged in any of the foregoing. 

4.    Integration Clause.    This Amendment 03 represents and documents the entirety of the agreement and understanding of the
parties hereto with respect to its subject matter. All prior understandings, whether oral or written, other than the Loan Documents, are hereby merged hereinto. NEITHER THE
LOAN AND SECURITY AGREEMENT NOR THIS AMENDMENT 03 MAY BE MODIFIED EXCEPT BY A WRITING SIGNED BY LENDER AND BORROWER. Each provision hereof shall be severable from every other
provision when determining its legal enforceability such that Lender's rights and remedies under this Amendment 03 and the Loan Documents may be enforced to the maximum extent permitted under
applicable law. This Amendment 03 shall be binding upon, and inure to the benefit of, each party's respective permitted successors and assigns. This Amendment 03 may be executed in 

2

 

counterpart
originals, all of which, when taken together, shall constitute one and the same original document. No provision of any other document between Lender and Borrower shall limit the
effectiveness hereof or the rights and remedies of Lender against Borrower. 

Except
as amended hereby, the Loan and Security Agreement remains unmodified and unchanged. 

 

 

							
	 BORROWER:	 	LENDER:
	
 ANACOR PHARMACEUTICALS, INC.	
 	
LIGHTHOUSE CAPITAL PARTNERS V, L.P.
	
 By:	
 	
/s/ LUCY O. DAY

 	
 	
 By:	
 	
 LIGHTHOUSE MANAGEMENT
	 	 	 	 	 	 	PARTNERS V, L.L.C., its general partner
	
 Name:	
 	
Lucy O. Day

 	
 	

 	
 	

 
	
 Title:	
 	
Vice President, Finance

 	
 	
By:	
 	
/s/ THOMAS CONNEELY

 
	

 	
 	
 	
 	
Name:	
 	
Thomas Conneely

 
	

 	
 	
 	
 	
Title:	
 	
Vice President

 

 

 ATTACHMENTS:  

Exhibit B-3—Second
Amended and Restated Secured Promissory Note

Exhibit C-3—Modification Warrant 

3

 

 EXHIBIT B-3

SECOND AMENDED AND RESTATED SECURED PROMISSORY NOTE  

$9,809,475.85

SECURED PROMISSORY NOTE  

This
SECOND AMENDED AND RESTATED SECURED PROMISSORY NOTE (this "Note") is made January 1, 2010,
by ANACOR PHARMACEUTICALS, INC. ("Borrower") in favor of LIGHTHOUSE
CAPITAL PARTNERS V, L.P. (collectively with its assigns, "Lender"). Initially capitalized terms used and not otherwise
defined herein are defined in that certain Loan and Security Agreement No. 5251 between Borrower and Lender dated June 30, 2006 (the "Loan
Agreement"), and amends and restates, but does not replace or novate, that Amended and Restated Secured Promissory Note dated April 1, 2008 and that Secured Promissory
Note dated May 1, 2008. 

FOR VALUE RECEIVED, Borrower promises to pay in lawful money of the United States, to the order of Lender, at 500 Drake's Landing Road, Greenbrae,
California 94904, or such other place as Lender may from time to time designate ("Lender's Office"), the principal sum of $9,809,475.85 (the
"Advance"), including interest on the unpaid balance and all other amounts due or to become due hereunder according to the terms hereof and of the Loan
Agreement. 

"Basic Rate" means a fixed per annum rate of interest equal to 9.25%. 

"Final Payment" means $1,454,500.00. 

"Loan Commencement Date" means the first day of the month following the Interest Only Period Maturity Date, but in no case later than July 1,
2010. 

"Maturity Date" means December 1, 2011, or if earlier, the date of prepayment under the Note. 

"Payment Date" means the first day of each calendar month. 

"Prepayment Fee" means 1% of the outstanding principal amount being prepaid if such prepayment is made in calendar year 2010 or thereafter. 

"Repayment Period" means the period beginning on the Loan Commencement Date and continuing until the Maturity Date. 

1.    Repayment.    Borrower shall pay principal and interest due hereunder pursuant to the terms of the Loan Agreement and this
Note. Interest shall accrue until this Note is paid in full. Prior to the Loan Commencement Date, Borrower shall pay to Lender, monthly in advance on each Payment Date, interest calculated using the
Basic Rate. Beginning on the Loan Commencement Date and on each Payment Date thereafter during the Repayment Period, Borrower shall make equal installments of principal and interest in advance,
calculated at the Basic Rate. On the Maturity Date, Borrower shall pay, in addition to all unpaid principal and interest outstanding hereunder, the Final Payment. 

2.    Interest.    Interest not paid when due will, to the maximum extent permitted under applicable law, become part of principal,
at Lender's option, and thereafter bear like interest as principal. All interest computation shall be based on a 360-day year and actual days elapsed. All Obligations not paid when due
shall bear interest at the Default Rate unless waived in writing by Lender. All
amounts paid hereunder will be applied to the Obligations in Lender's discretion and as provided in the Loan Agreement. 

3.    Voluntary Prepayment.    Borrower may prepay the Note if and only if Borrower pays to Lender (i) the outstanding
principal amount of this Note and any unpaid accrued interest; (ii) the Final Payment; (iii) the Prepayment Fee; (iv) the Second Forbearance Fee (if not previously paid), and
(v) all other sums, if any, that shall have become due and payable hereunder with respect to this Note. 

1

 

4.    Collateral.    This Note is secured by the Collateral. 

5.    Waivers.    Borrower, and all guarantors and endorsers of this Note, regardless of the time, order or place of signing, hereby
waive notice, demand, presentment, protest, and notices of every kind, presentment for the purpose of accelerating maturity, diligence in collection, and, to the fullest extent permitted by law, all
rights to plead any statute of limitations as a defense to any action on this Note. 

6.    Choice of Law; Venue.    THIS NOTE SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF
CALIFORNIA, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. EACH OF BORROWER AND LENDER HEREBY SUBMITS TO THE EXCLUSIVE JURISDICTION AND VENUE OF THE STATE AND FEDERAL COURTS LOCATED IN THE CITY AND
COUNTY OF SAN FRANCISCO, STATE OF CALIFORNIA. BORROWER AND LENDER EACH HEREBY WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS NOTE. EACH
PARTY FURTHER WAIVES ANY RIGHT TO CONSOLIDATE ANY ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER ACTION IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.

7.    Miscellaneous.    THIS NOTE MAY BE MODIFIED ONLY BY A WRITING SIGNED BY BORROWER AND LENDER. Each
provision hereof is severable from every other provision hereof and of the Loan Agreement when determining its legal enforceability. Sections and subsections are titled for convenience, and not for
construction. "Hereof," "herein," "hereunder," and similar words refer to this Note in its entirety. "Or" is not necessarily exclusive. "Including" is not limiting. The terms and conditions hereof
inure to the benefit of and are binding upon the parties' respective permitted successors and assigns. This Note is subject to all the terms and conditions of the Loan Agreement. 

IN WITNESS WHEREOF, Borrower has caused this Note to be executed by a duly authorized officer as of the day and year first above written. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
By:	
 	
 

 
	

 	
 	
Name:	
 	
  

 
	

 	
 	
Title:	
 	
  

 

 

 2

 

 EXHIBIT C-3  

THIS
WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "1933 ACT"), OR ANY APPLICABLE STATE SECURITIES LAWS, AND
MAY NOT BE SOLD OR TRANSFERRED UNLESS SUCH SALE OR TRANSFER IS IN ACCORDANCE WITH THE REGISTRATION REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS OR SOME OTHER EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF SUCH ACT AND APPLICABLE LAWS IS AVAILABLE WITH RESPECT THERETO. 

PREFERRED
STOCK PURCHASE WARRANT 

 

 

							
	Warrant No.	 	 	 	 	 	Number of Shares: 203,118
	 	 	

  	 	 	 	Series E Preferred Stock

 

 ANACOR PHARMACEUTICALS, INC.  

Effective
as of January 1, 2010 

Void
after January 1, 2017 

1.    Issuance.    This Preferred Stock Purchase Warrant (the "Warrant") is issued
to LIGHTHOUSE CAPITAL PARTNERS V, L.P. by ANACOR PHARMACEUTICALS, INC., a Delaware
corporation (hereinafter with its successors called the "Company"). 

2.    Purchase Price; Number of Shares.    The registered holder of this Warrant (the
"Holder"), is entitled upon surrender of this Warrant with the subscription form annexed hereto duly executed, at the principal office of the Company,
to purchase from the Company, at a price per share of $3.3872 (the "Purchase Price"), 203,118 fully paid and nonassessable shares of the Company's
Series E Preferred Stock, $0.001 per share par value (the "Preferred Stock"). 

Until
such time as this Warrant is exercised in full or expires, the Purchase Price and the securities issuable upon exercise of this Warrant are subject to adjustment as hereinafter provided. The
person or persons in whose name or names any certificate representing shares of Preferred Stock is issued hereunder shall be deemed to have become the holder of record of the shares represented
thereby as at the close of business on the date this Warrant is exercised with respect to such shares, whether or not the transfer books of the Company shall be closed. 

3.    Payment of Purchase Price.    The Purchase Price may be paid (i) in cash or by check, (ii) by the surrender by
the Holder to the Company of any promissory notes or other obligations issued by the Company, with all such notes and obligations so surrendered being credited against the Purchase Price in an amount
equal to the principal amount thereof plus accrued interest to the date of surrender, or (iii) by any combination of the foregoing. 

4.    Net Issue Election.    The Holder may elect to receive, without the payment by the Holder of any additional consideration,
shares of Preferred Stock equal to the value of this Warrant or any portion hereof by the surrender of this Warrant or such portion to the Company, with the net issue election notice annexed hereto
duly executed, at the principal office of the Company. Thereupon, the Company 

1

 

shall
issue to the Holder such number of fully paid and nonassessable shares of Preferred Stock as is computed using the following formula: 

							
	 	 	 X=	 	 Y (A-B)

 A
 	 	 

				
	 	where: X =	 	 the number of shares of Preferred Stock to be issued to the Holder pursuant to this Section 4.
	
 	
Y =	
 	
 the number of shares of Preferred Stock covered by this Warrant in respect of which the net issue election is made pursuant to this Section 4.
	
 	
A =	
 	
 the Fair Market Value (defined below) of one share of Preferred Stock, as determined at the time the net issue election is made pursuant to this Section 4.
	
 	
B =	
 	
 the Purchase Price in effect under this Warrant at the time the net issue election is made pursuant to this Section 4.

        "Fair Market Value" of a share of Preferred Stock (or fully paid and nonassessable shares
of the Company's common stock, $0.001 par value (the "Common Stock") if the Preferred Stock has been automatically converted into Common Stock) as of
the date that the net issue election is made (the "Determination Date") shall mean: 

        (a)   If the net issue election is made in connection with and contingent upon the closing of the sale of the Company's Common
Stock to the public in a public offering pursuant to a Registration Statement under the 1933 Act (a "Public Offering"), and if the Company's
Registration Statement relating to such Public Offering ("Registration Statement") has been declared effective by the Securities and Exchange
Commission, then the initial "Price to Public" specified in the final prospectus with respect to such offering multiplied by the number of shares of Common Stock into which each share of Preferred
Stock is then convertible. 

        (b)   If the net issue election is not made in connection with and contingent upon a Public Offering, then as follows: 

          (i)  If traded on a securities exchange, the fair market value of the Common Stock shall be deemed to be the average of the
closing or last reported sale prices of the Common Stock on such exchange over the five day period ending five trading days prior to the Determination Date, and the fair market value of the Preferred
Stock shall be deemed to be such fair market value of the Common Stock multiplied by the number of shares of Common Stock into which each share of Preferred Stock is then convertible; 

         (ii)  If otherwise traded in an over-the-counter market, the fair market value of the Common Stock
shall be deemed to be the average of the closing ask prices of the Common Stock over the five day period ending five trading days prior to the Determination Date, and the fair market value of the
Preferred Stock shall be deemed to be such fair market value of the Common Stock multiplied by the number of shares of Common Stock into which each share of Preferred Stock is then convertible; and 

       (iii)  If there is no public market for the Common Stock, then fair market value shall be determined in good faith by the
Company's Board of Directors. 

5.    Partial Exercise.    This Warrant may be exercised in part, and the Holder shall be entitled to receive a new warrant, which
shall be dated as of the date of this Warrant, covering the number of shares in respect of which this Warrant shall not have been exercised. 

6.    Fractional Shares.    In no event shall any fractional share of Preferred Stock be issued upon any exercise of this Warrant.
If, upon exercise of this Warrant in its entirety, the Holder would, except as 

2

 

provided
in this Section 6, be entitled to receive a fractional share of Preferred Stock, then the Company shall issue the next lower number of
full shares of Preferred Stock and shall pay to the Holder a cash amount equal to the Fair Market Value (as of the date of exercise) of such fractional share of Preferred Stock. 

7.    Expiration Date; Automatic Exercise.    This Warrant shall expire at the close of business on January 1, 2017, and
shall be void thereafter (the "Expiration Date"). Notwithstanding the term of this Warrant fixed pursuant to this  Section 7, and provided Holder has
received advance written notice of at least ten (10) days and has not earlier exercised this Warrant,
and provided this Warrant has not been assumed by the successor entity (or parent thereof), upon the consummation of a Merger (as defined below), this Warrant shall automatically be exercised pursuant
to Section 4 hereof, without any action by Holder. "Merger" means: (i) a sale of all or
substantially all of the Company's assets to an Unaffiliated Entity (as defined below), or (ii) the merger, consolidation or acquisition of the Company with, into or by an Unaffiliated Entity
(other than a merger or consolidation for the principle purpose of changing the domicile of the Company or a bona fide round of preferred stock equity financing), that results in the transfer of fifty
percent (50%) or more of the outstanding voting power of the Company. "Unaffiliated Entity" means any entity that is owned or controlled by parties who
own less than twenty percent (20%) of the combined voting power of the voting securities of the Company immediately prior to such merger, consolidation or acquisition. Notwithstanding the foregoing,
in the event that any outstanding warrants to purchase equity securities of the same series of Preferred Stock of the Company are assumed by the successor entity of a Merger (or parent thereof), this
Warrant shall also be similarly assumed. The Company agrees to promptly give the Holder written notice of any proposed Merger and written notice of termination of any proposed Merger. Notwithstanding
anything to the contrary in this Warrant, the Holder may rescind any exercise of its purchase rights after a notice of termination of the proposed Merger if the exercise of this Warrant occurred after
the Company notified the Holder that the Merger was proposed or if the exercise was otherwise precipitated by such proposed Merger, provided, however that such rescission right must be exercised
within thirty (30) days of receipt of such written notice of termination of the proposed Merger. In the event of such rescission, this Warrant will continue to be exercisable on the same terms
and conditions. 

8.    Reserved Shares; Valid Issuance.    The Company covenants that it will at all times from and after the date hereof reserve and
keep available such number of its authorized shares of Preferred Stock and Common Stock free from all preemptive or similar rights therein, as will be sufficient to permit, respectively, the exercise
of this Warrant in full and the conversion into shares of Common Stock of all shares of Preferred Stock receivable upon such exercise. The Company further represents that such
shares as may be issued pursuant to such exercise and/or conversion will, upon issuance, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with
respect to the issuance thereof. 

9.    Stock Splits and Dividends.    If after the date hereof the Company shall subdivide the Preferred Stock, by
split-up or otherwise, or combine the Preferred Stock, or issue additional shares of Preferred Stock in payment of a stock dividend on the Preferred Stock, the number of shares of
Preferred Stock issuable on the exercise of this Warrant shall forthwith be proportionately increased in the case of a subdivision or stock dividend, or proportionately decreased in the case of a
combination, and the Purchase Price shall forthwith be proportionately decreased in the case of a subdivision or stock dividend, or proportionately increased in the case of a combination. 

10.    Adjustments for Diluting Issuances.    The other antidilution rights applicable to the Preferred Stock and the Common Stock
of the Company are set forth in the Amended and Restated Certificate of Incorporation, as amended from time to time (the "Articles"), a true and
complete copy in its current form which is attached hereto as Exhibit A . Such rights shall not be restated, amended or modified in any manner
which affects the Holder differently than the holders of Preferred Stock without such Holder's prior written consent. The Company shall promptly provide the Holder hereof 

3

 

with
any restatement, amendment or modification to the anti-dilution rights in such Articles promptly after the same has been made. 

11.    Reclassifications.    If after the date hereof the Company shall enter into any Reorganization (as hereinafter defined),
then, as a condition of such Reorganization, lawful provisions shall be made, and duly executed documents evidencing the same from the Company or its successor shall be delivered to the Holder, so
that the Holder shall thereafter have the right to purchase, at a total price not to exceed that payable upon the exercise of this Warrant in full, the kind and amount of shares of stock and other
securities and property receivable upon such Reorganization by a holder of the number of shares of Preferred Stock which might have been purchased by the Holder immediately prior to such
Reorganization, and in any such case appropriate provisions shall be made with respect to the rights and interest of the Holder to the end that the provisions hereof (including without limitation,
provisions for the adjustment of the Purchase Price and the number of shares issuable hereunder and the provisions relating to the net issue election) shall thereafter be applicable in relation to any
shares of stock or other securities and property thereafter deliverable upon exercise hereof. For the purposes of this Section 11, the term
"Reorganization" shall include any reclassification, capital reorganization (other than as a result of a subdivision, combination or stock dividend
provided for in Section 9 hereof). 

12.    Certificate of Adjustment.    Whenever the Purchase Price is adjusted, as herein provided, the Company shall promptly deliver
to the Holder a certificate of the Company's chief financial officer setting forth the Purchase Price after such adjustment and setting forth a brief statement of the facts requiring such adjustment. 

13.    Notices of Record Date, Etc.    In the event of: 

        (a)   any taking by the Company of a record of the holders of any class of securities for the purpose of determining the
holders thereof who are entitled to receive any dividend or other distribution, or any right to subscribe for, purchase, sell or otherwise acquire or dispose of any shares of stock of any class or any
other securities or property, or to receive any other right; 

        (b)   any reclassification of the capital stock of the Company, capital reorganization of the Company, consolidation or merger
involving the Company, or sale or conveyance of all or substantially all of its assets; or 

        (c)   any voluntary or involuntary dissolution, liquidation or winding-up of the Company; then in each such event
the Company will provide or cause to be provided to the Holder a written notice thereof. Such notice shall be provided at least ten (10) business days prior to the date specified in such notice
on which any such action is to be taken. 

14.    Representations, Warranties and Covenants.    This Warrant is issued and delivered by the Company and accepted by each Holder
on the basis of the following representations, warranties and covenants made by the Company: 

        (a)   The Company has all necessary authority to issue, execute and deliver this Warrant and to perform its obligations
hereunder. This Warrant has been duly authorized, issued, executed and delivered by the Company and is the valid and binding obligation of the Company, enforceable in accordance with its terms. 

        (b)   The shares of Preferred Stock issuable upon the exercise of this Warrant have been duly authorized and reserved for
issuance by the Company and, when issued in accordance with the terms hereof, will be validly issued, fully paid and nonassessable. 

        (c)   The issuance, execution and delivery of this Warrant do not, and the issuance of the shares of Preferred Stock upon the
exercise of this Warrant in accordance with the terms hereof will not, (i) violate or contravene the Company's Articles or by-laws, or any law, statute, regulation, 

4

 

rule,
judgment or order applicable to the Company, (ii) violate, contravene or result in a breach or default under any contract, agreement or instrument to which the Company is a party or by
which the Company or any of its assets are bound or (iii) require the consent or approval of or the filing of any notice or registration with any person or entity, except for filings required
under California securities laws. 

        (d)   As long as this Warrant is, or any shares of Preferred Stock issued upon exercise of this Warrant or any shares of Common
Stock issued upon conversion of such shares of Preferred Stock are, issued and outstanding, the Company will provide to the Holder financial information in parity with that given to other holders of
Series E Preferred Stock. 

        (e)   As of the date hereof, the authorized capital stock of the Company consists of (i) 75,500,000 shares of Common
Stock, of which 7,218,509 shares are issued and outstanding and 203,118 shares are reserved for issuance upon the exercise of this Warrant with respect to Common Stock and the conversion of the
Preferred Stock into Common Stock if this Warrant is exercised with respect to Preferred Stock, and (ii) 4,228,329 shares of Series A-1 Preferred Stock, of which 4,228,329
are issued and outstanding shares; (iii) 1,198,046 shares of Series A-2 Preferred Stock, of which 1,198,046 are issued and outstanding shares (iv) 3,339,341 shares of
Series B Preferred Stock, of which 3,339,341 are issued and outstanding shares; (v) 28,089,885 shares of Series C Preferred Stock, of which 28,089,885 are issued and outstanding
shares; (vi) 3,716,626 shares of Series D Preferred Stock, of which 2,930,500 are issued and outstanding shares, and (v) 15,100,000 shares of Series E Preferred Stock, of
which 14,761,455 are issued and outstanding shares. Attached hereto as Exhibit B is a capitalization table as of December 31, 2009,
summarizing the capitalization of the Company. At the request of Holder, not more than once per calendar quarter, the Company will provide Holder with a current capitalization table indicating
changes, if any, to the number of outstanding shares of common stock and preferred stock. 

15.    Registration Rights.    The Company has entered into an Amended and Restated Investors' Rights Agreement in the form attached
hereto as Exhibit C. 

16.    Amendment.    The terms of this Warrant may be amended, modified or waived only with the written consent of the Holder. 

17.    Representations and Covenants of the Holder.    This Warrant has been entered into by the Company in reliance upon the
following representations and covenants of the Holder, which by its execution hereof the Holder hereby confirms: 

        (a)    Investment Purpose.    The right to acquire Preferred Stock or
the Preferred Stock issuable upon exercise of the Holder's rights contained herein will be acquired for investment and not with a view to the sale or distribution of any part thereof, and the Holder
has no present intention of selling or engaging in any public distribution of the same except pursuant to a registration or exemption. 

        (b)    Accredited Investor.    Holder is an "accredited investor"
within the meaning of the Securities and Exchange Rule 501 of Regulation D, as presently in effect. 

        (c)    Private Issue.    The Holder understands (i) that the
Preferred Stock issuable upon exercise of the Holder's rights contained herein is not registered under the 1933 Act or qualified under applicable state securities laws on the ground that the issuance
contemplated by this Warrant will be exempt from the registration and qualifications requirements thereof, and (ii) that the Company's reliance on such exemption is predicated on the
representations set forth in this Section 17. 

5

 

        (d)    Financial Risk.    The Holder has such knowledge and experience
in financial and business matters as to be capable of evaluating the merits and risks of its investment and has the ability to bear the economic risks of its investment. 

        (e)    Legends.    The Holder understands that the Securities, and any
securities issued in respect thereof or exchange therefor, may bear one or all of the following legends: 

          (i)  "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND
HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933." 

         (ii)  Any legend required by the Blue Sky laws of any state to the extent such laws are applicable to the shares represented
by the certificate so legended. 

        (f)    Lock-up Agreement.    In connection with the
initial public offering of the Company's securities and upon request of the Company or the underwriters managing such offering of the Company's securities, the Holder agrees not to sell, make any
short sale of, loan, grant any option for the purchase of, or otherwise dispose of any securities of the Company, however or whenever acquired (other than those included in the registration) without
the prior written consent of the Company or such underwriters, as the case may be, for such period of time (not to exceed 180 days or such longer period as may be required by the underwriters
to comply with FINRA Rule 2711) from the effective date of such registration as may be requested by the Company or such managing underwriters and to execute an agreement reflecting the
foregoing as may be requested by the underwriters at the time of the Company's initial public offering. 

        The
obligations described in this Section 17(f) shall apply only if all executive officers and directors of the Company, and all 1%
and greater security holders (on a basis assuming full conversion and exercise of all convertible or exercisable securities) enter into similar agreements. If the Company or the underwriter of any
public offering of the Company's securities waives or terminates any standoff or lockup restrictions imposed on any holder of securities of the Company, then such waiver or termination shall be
granted to all Holders subject to standoff or lockup restrictions pro rata based on the number of shares of Common Stock beneficially held by such
holder and the Holders (the "Pro Rata Release"); provided, however, that permitted concurrent sales of common stock by any security holders of the
Company consisting of its founders and the institutions with which they are affiliated, in an amount not to exceed $10 million, made to Schering-Plough and/or SmithKline Beecham, D/B/A
GlaxoSmithKline at the time of the Company's initial public offering shall not entitle the Holder to the Pro Rata Release. From and after the date of this Warrant, the Company shall use its best
efforts to ensure that all holders of capital stock of the Company agree to be bound by terms substantially similar to those set forth in this  Section 17(f). 

18.    Notices, Transfers, Etc.

        (a)   Any notice or written communication required or permitted to be given to the Holder may be given by certified mail or
delivered to the Holder at the address most recently provided by the Holder to the Company. 

        (b)   Subject to compliance with applicable federal and state securities laws, this Warrant may be transferred by the Holder
with respect to not less than 25% of the number of the shares of Preferred Stock purchasable hereunder, provided that the transferee is not a competitor of the 

6

 

Company
and provided further that the transferee agrees to be bound by all of the terms and conditions of this Warrant, including, with limitations the representations and covenants contained in  Section 17. Upon surrender of this Warrant to the Company, together with the assignment notice annexed hereto duly executed, for transfer of this
Warrant as an entirety by the Holder, the Company shall issue a new warrant of the same denomination to the assignee. Upon surrender of this Warrant to the Company, together with the assignment hereof
properly endorsed, by the Holder for transfer with respect to a portion of the shares of Preferred Stock purchasable hereunder, the Company shall issue a new warrant to the assignee, in such
denomination as shall be requested by the Holder hereof, and shall issue to such Holder a new warrant covering the number of shares in respect of which this Warrant shall not have been transferred.
Any purported transfer in violation of this Section 18(b) shall be void. 

        (c)   In case this Warrant shall be mutilated, lost, stolen or destroyed, the Company shall issue a new warrant of like tenor
and denomination and deliver the same (i) in exchange and substitution for and upon surrender and cancellation of any mutilated Warrant, or (ii) in lieu of any Warrant lost, stolen or
destroyed, upon receipt of an affidavit of the Holder or other evidence reasonably satisfactory to the Company of the loss, theft or destruction of such Warrant 

19.    No Impairment.    The Company will not, by amendment of its Articles or through any reclassification, capital reorganization,
consolidation, merger, sale or conveyance of assets, dissolution, liquidation, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance of performance of any of
the terms of this Warrant. 

20.    Governing Law.    The provisions and terms of this Warrant shall be governed by and construed in accordance with the internal
laws of the State of California without giving effect to its principles regarding conflicts of laws. 

21.    Successors and Assigns.    This Warrant shall be binding upon the Company's successors and assigns and shall inure to the
benefit of the Holder's successors, legal representatives and permitted assigns. 

22.    Business Days.    If the last or appointed day for the taking of any action required or the expiration of any rights granted
herein shall be a Saturday or Sunday or a legal holiday in California, then such action may be taken or right may be exercised on the next succeeding day which is not a Saturday or Sunday or such a
legal holiday. 

23.    Qualifying Public Offering.    If the Company shall effect a firm commitment underwritten public offering of shares of Common
Stock which results in the conversion of the Preferred Stock into Common Stock pursuant to the Company's Articles in effect immediately prior to such offering, then, effective upon such conversion,
this Warrant shall change from the right to purchase shares of Preferred Stock to the right to purchase shares of Common Stock, and the Holder shall thereupon have the right to purchase, at a total
price equal to that payable upon the exercise of this Warrant in full, the number of shares of Common Stock which would have been receivable by the Holder upon the exercise of this Warrant for shares
of Preferred Stock immediately prior to such conversion of such shares of Preferred Stock into shares of Common Stock, and in such event appropriate provisions shall be made with respect to the rights
and interest of the Holder to the end that the provisions hereof (including, without limitation, the provisions for the adjustment of the Purchase Price and of the number of shares purchasable upon
exercise of this Warrant and the provisions relating to the net issue 

7

 

election)
shall thereafter be applicable to any shares of Common Stock deliverable upon the exercise hereof. 

 

 

					
	 	 	 ANACOR PHARMACEUTICALS, INC.
	

 	
 	
 By:	
 	

 
	 	 	 	 	

  
	

 	
 	
 Name:	
 	

 
	 	 	 	 	

  
	

 	
 	
 Title:	
 	

 
	 	 	 	 	

  

 

 8

 

  Subscription  

 

 

					
	To:	 	  

 	 	 
	Date:	 	  

 	 	 
	

The undersigned hereby subscribes
for                                    shares of Preferred Stock
covered by this Warrant. The certificate(s) for such shares shall be issued in the name of the undersigned or as otherwise indicated below:
	

  

  Signature	
 	

 
	

  

  Name for Registration	
 	

 
	

  

  Mailing Address

	
 	

 

 

  Net Issue Election Notice  

 

 

							
	To:	 	  

 	 	Date:	 	    

 
	

The undersigned hereby elects under Section 4 to surrender the right to purchase shares of Preferred Stock pursuant to this Warrant. The certificate(s) for such shares issuable upon such net issue
election shall be issued in the name of the undersigned or as otherwise indicated below:
	

  

  Signature	
 	

 	
 	

 
	

  

  Name for Registration	
 	

 	
 	

 
	

 

  Mailing Address

	
 	

 	
 	

 

 

  Assignment  

For
value received                                    hereby sells,
assigns and transfers unto 

 

 

					
	 

  [Please print or typewrite name and address of Assignee]
	

the within Warrant, and does hereby irrevocably constitute and
appoint                                    its attorney to transfer
the within Warrant on the books of the within named Company with full power of substitution on the premises.
	
 Dated:	
 	
 

 	
 	

 
	

  

  Signature	
 	

 
	

  

  Name for Registration	
 	

 
	

In the Presence of:	
 	

 
	

  

 	
 	

 

 

 1

 

 EXHIBIT A

 Amended and Restated Certificate of Incorporation  

See attached pages.

1

 

 EXHIBIT B

 Capitalization Table  

1

 

 EXHIBIT C

 Amended and Restated Investors' Rights Agreement  

See attached pages

1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00178-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00178-of-00352.parquet"}]]