Document:

Employment Agreement, between the Registrant and Tito A. Serafini

 Exhibit 10.6 
  
 RENOVIS NEUROSCIENCE, INC. 
  
 June 7, 2000 
  
 Dr. Tito Serafini 
  
 Re: Employment Agreement 
  
 Dear Dr. Serafini: 
  
 On behalf
of Renovis Neuroscience, Inc. (the “Company”), I am pleased to provide you with this Employment Agreement (the “Agreement”) to retain your services for the position of Vice President of Research and Technology (an officer of the
Company, reporting directly to the Chairman or Chief Executive Officer or other Company officer as specified by the Board of Directors) pursuant to the terms hereof. 
  
 1. DUTIES. As the Vice President of Research and Technology, you will perform the duties customarily associated
with this position, unless otherwise mutually agreed in writing. Subject to the other provisions in this Agreement, the Company may change your duties and reporting relationship at its discretion. You shall devote your full time and attention during
normal business hours to the business affairs of the Company, except for reasonable vacations, handling of reasonable personal matters and periods of illness or incapacity. It is agreed that your employment will commence full time with the Company
on July 1, 2000 (the “Start Date”), and before that time you will continue to act as a consultant to the Company pursuant to the Scientific Advisory Board consulting agreement attached hereto as Exhibit B (the “SAB Agreement”).

  
 2. BOARD OF
DIRECTORS. You have been elected to serve as a member of the Company’s Board of Directors, effective on the Start Date. On the Start Date, you will assume such Board member duties, rights and responsibilities as are
established by the Company’s bylaws and certificate of incorporation and by applicable law. Such election in the future shall be subject to continued approval of the Company’s shareholders. 
  
 3. BASE SALARY. Pursuant to the terms of the SAB
Agreement, you will be paid a monthly fee of $5,000 per month (without any payroll or similar deductions or withholdings) from February 1, 2000 through the Start Date, to be paid on a semi-monthly basis, for consulting services. Commencing on the
Start Date, you shall receive an annual base salary of $165,000, to be paid on a semi-monthly basis, less payroll deductions and withholdings. In addition, the Company shall provide you a loan in association with your purchase of Founder’s
Stock, equal to the sum of: 1) the difference between the prior anticipated and actual cost of your Founder’s Stock, and 2) the added taxes you will consequently incur, which loan will be forgiven in equal parts for each year of your employment
and in its entirety if you are terminated without Cause or 

 
per a Constructive Termination (both defined below). You will be provided with both a salary and performance review on an annual calendar year basis by the
Board of Directors of the Company (the “Board”) or the Chief Executive Officer, if the Board hires one, and you will be eligible for adjustments of your compensation as merited. 
  
 4. INCENTIVE COMPENSATION. You shall be entitled to an annual (calendar year) bonus in an amount
of up to 30% of your annual base salary (on a pro rata basis for year 2000 only) based upon your attainment of mutually agreeable performance targets established by the Board. Your bonus shall be paid in accordance with standard Company practices,
and you will be eligible for adjustments of your bonus as merited. 
  
 5. STOCK OPTIONS. Subject to the additional terms set forth in the governing Stock Option Agreement and the Company’s Stock Option Plan, you will be granted stock options and purchase rights as
follows: 
  
 (a) Founder’s Stock. You
will be granted the right to purchase 400,000 shares of the Company’s founder’s common stock (the “Founder’s Stock”). The Founder’s Stock shall vest, subject to your continuing employment with the Company, over four (4)
years, such that 25% shall vest on the first anniversary of February 1, 2000, and the remainder vesting in equal amounts over a three year period at the end of each month thereafter. 
  
 (b) Stock Option. Subject to your execution of the Agreement,
you will also be granted an option (with the opportunity to immediately exercise the entire option) to purchase 250,000 shares of the Company’s common stock at the purchase price of the fair market value of the common stock at the time of the
option grant (the “Stock Option”). The Stock Option shall vest, subject to your continuing employment with the Company, as follows: (i) 25% of the options shall vest on the first anniversary of your commencement of employment with the
Company, and (ii) the balance of the options shall vest in equal monthly installments thereafter over the following thirty-six (36) months. The Stock Option shall be granted pursuant to the Company’s standard stock option plan and stock option
agreement. 
  
 (c) Additional Stock Options. You
will be eligible for the grant of additional stock options, at the Board’s sole discretion, in conjunction with your annual performance review or bonus payment. 
  
 6. BENEFITS. The Company will provide you with medical, dental, life, supplemental life, disability benefits, sick
leave, holidays and many other Company-sponsored programs available to its exempt employees. The Company may, from time to time, change the above benefits. 
  
 Additionally, the Company shall also defend, indemnify and hold you harmless from any obligations, claims, etc. to the fullest extent possible pursuant to the terms of
the Company’s Articles of Incorporation, Bylaws and the attached Indemnification Agreement (Exhibit E). 
  
 7. EXPENSES. You shall be entitled to reimbursement for all ordinary and reasonable out-of-pocket business expenses which are have been or are reasonably incurred by you in furtherance of the
Company’s business and in accordance with the Company’s standard policies. 
  

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 8. VACATION. You will be entitled to 120 hours (weekday business hours) of annual vacation
time, which will accrue on a pro-rata daily basis beginning on your Start Date. You may accrue vacation time up to a maximum of 240 hours. After you reach this maximum accrual, you will not continue to accrue vacation time until your accrued balance
drops below 240 hours. You will also have two (2) personal days of your selection per calendar year. 
  
 9. COMPANY POLICIES AND CONFIDENTIALITY AGREEMENT. As an employee of the Company, you will be expected to abide by all of the
Company’s policies and procedures. As a condition of your employment, you agree to sign and to abide by the terms of a Confidentiality and Proprietary Information Agreement with the Company. You have attached, as Exhibit C, a list describing
all inventions, original works of authorship, developments, improvements and trade secrets (collectively, “Inventions”) which were made by you prior to your employment with the Company, which belong to you, which may relate to the
Company’s proposed business and products, and which are expressly not assigned to the Company. The Parties recognize that Section 2870 of the California Labor Code (attached as Exhibit D) also exempts from assignment certain of your future
Inventions developed during the period of your Company employment. 
  
 10.
OTHER AGREEMENTS. By accepting this Agreement, you represent and warrant that your performance of your duties for the Company will not violate any agreements, obligations or understandings that you may have
with any third party or prior employer. You agree not to make any unauthorized disclosure or use, on behalf of the Company, of any confidential information belonging to any of your former employers. You also represent that you are not in
unauthorized possession of any materials containing a third party’s confidential and proprietary information. Of course, during your employment with the Company, you may make use of information generally known and used by persons with training
and experience comparable to your own, and information which is common knowledge in the industry or is otherwise legally available in the public domain. 
  
 11. DUTY OF LOYALTY. While employed by the Company (i.e., commencing July 1, 2000), you will not engage
in any business activity in competition with the Company nor make preparations to do so, and you will not engage in any outside employment or consulting without written authorization from the Company. 
  
 12. TERMINATION. As an employee of the Company, you may
terminate your employment at any time and for any reason whatsoever simply by notifying the Company. Similarly, the Company may terminate your employment at any time and for any reason whatsoever, with or without cause. Your at-will employment
relationship with the Company cannot be changed except in writing signed by a duly authorized officer of the Company. 
  
 13. SEVERANCE BENEFITS. 
  
 (a) Termination By The Company Without Cause. If your employment by the Company and this Agreement is terminated by the Company without Cause (as
defined below), or if there is a Constructive Termination (as defined below), and if you provide the Company with a signed general release of all claims, a form of which is set forth in Exhibit A, the Company shall provide you with the following
severance benefits: (1) continuation of your base salary for a period of six (6) months after your termination date (you would be entitled to all your 

  

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compensation earned through your termination date whether or not you provide the release); (2) immediate acceleration of your Founder’s Stock such that
all such Founder’s Stock shall be fully vested; and (3) immediate acceleration of the vesting of your Stock Option such that an additional six (6) months of options shall be vested. 
  
 You understand and agree that you shall not be entitled to any other severance pay, severance benefits, or any other compensation or
benefits other than those already earned or vested or otherwise as set forth in this paragraph in the event of such a termination. 
  
 (b) Termination By The Company With Cause Or Termination By You. If this Agreement is terminated by the Company at any time with Cause, or
if you terminate your employment with the Company under this Agreement (other than a Constructive Termination, as defined below), you shall not be entitled to any severance pay, severance benefits, or any compensation or benefits from the Company
whatsoever, other than payment of all amounts of compensation actually earned (and benefits vested) through the date of termination. 
  
 (c) Termination Due to Change in Control. You shall also be entitled to the following severance benefits in the event of the occurrence of a
Change in Control while you are employed by the Company, but only if upon or within thirteen (13) months following the occurrence of the Change of Control, either (i) you resign because your position, authority or responsibilities have been
materially and substantially reduced as a result of the Change in Control, or (ii) your employment by the Company is terminated without Cause, and provided that in either case you promptly thereafter provide the Company with a signed general release
of all claims, a form of which is sent forth in Exhibit A: (1) continuation of your base salary for a period of twelve (12) months after your termination date; (2) immediate acceleration of your Founder’s Stock and Stock Option such that all
outstanding Founder’s Stock and Stock Option shall be fully vested. 
  
 (d) Definitions: 
  
 (1) Cause. “Cause” for purposes of this Agreement shall mean: (i) theft, dishonesty or intentional falsification of any employment or Company records; (ii) malicious or reckless material disclosure of the Company’s
material confidential or proprietary information; (iii) commission of any immoral or illegal act or any gross or willful misconduct, where such act or misconduct has (A) materially undermined the ability of the Company’s management to entrust
you with important matters or otherwise work effectively with you, (B) caused or contributed substantially to the Company’s loss of significant revenues or business opportunities, or (C) significantly and detrimentally damaged the business or
reputation of the Company or any of its subsidiaries; and/or (iv) the failure or refusal by you to work diligently to perform tasks or pursue goals reasonably requested by the Board of Directors or the Chief Executive Officer with the approval of
the Board of Directors, provided such failure or refusal continues after the receipt of notice in writing of such failure or refusal and a reasonable opportunity thereafter to correct the problem. Cause shall expressly not include: (i) a physical or
mental disability, or (ii) refusal to violate the law or otherwise engage in dishonesty or intentional falsification of records. 
  

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 (2) Change in Control. For purposes of this Agreement, the term “Change of Control”
means the consummation of any of the following transactions: 
  
 a. the stockholders of the Company approve a business combination (e.g., a merger or consolidation) of the Company with any other corporation or other type of business entity (e.g., a limited liability company), other
than a business combination which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving
entity) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such controlling surviving entity outstanding immediately after such business combination; or 
  
 b. the sale, lease, exchange or other transfer or disposition by the
Company of all or substantially all (more than seventy percent (70%)) of the Company’s assets by value. 
  
 (3) Constructive Termination. For purposes of this Agreement, the term “Constructive Termination” means the material and substantial
reduction in your responsibilities and duties at the Company without Cause which results in your resignation within sixty (60) days from the date of such reduction. In addition, it will be deemed a Constructive Termination if you resign within the
first three years of employment as a result of a requirement (during such period) by the Company that you report to a person or persons other than the Chairman of the Board of Directors, Chief Executive Officer or persons serving in similar
capacities. 
  
 14. RETURN OF
MATERIALS. At the termination of all your professional relationships with the Company, you will promptly return to the Company, and will not take with you or use, all items of any nature that belong to the Company, and all
materials (in any form, format, or medium) containing or relating to the Company’s business. 
  
 15. NONSOLICITATION. You agree that for two (2) years following the termination of your employment, you will not, either directly or through others, solicit or attempt to solicit any employee,
consultant or independent contractor of the Company to terminate his or her relationship with the Company in order to become an employee, consultant or independent contractor to or for any other person or business entity. 
  
 16. ENTIRE AGREEMENT. This Agreement, including Exhibits
A through E attached hereto, constitutes the complete, final and exclusive embodiment of the entire agreement between you and the Company with respect to the terms and conditions of your employment specified herein. If you enter into this Agreement
you are doing so voluntarily, and without reliance upon any promise, warranty or representation, written or oral, other than those expressly contained herein. This Agreement supersedes any other such promises, warranties, representations or
agreements. This Agreement does not, however, supersede or modify your written (if any) SAB Agreement, Proprietary Information and Inventions Agreement, or any governing Stock Option Agreements or Stock Option Plans. This Agreement may not be
amended or modified except by a written instrument signed by you and a duly authorized officer of the Company. 
  

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 17. ENFORCEABILITY. If any provision of this Agreement is determined to be invalid or
unenforceable, in whole or in part, this determination will not affect any other provision of this Agreement, and the Agreement, including the invalid or unenforceable provisions, should be enforced insofar as possible to achieve the intent of the
parties. 
  
 18. BINDING NATURE.
This Agreement will be binding upon and inure to the benefit of the personal representatives and successors of the respective parties hereto. 
  
 19. GOVERNING LAW. This Agreement will be governed by and construed in accordance with the laws of the State of
California. 
  
 20. DISPUTE
RESOLUTION / ATTORNEYS’ FEES. Unless otherwise prohibited by law or specified below, all disputes, claims, and causes of action (including but not limited to any claims of statutory
discrimination of any type), in law or equity, arising from or relating to this Agreement or its enforcement, performance, breach, or interpretation, or to your employment with the Company or the termination of that employment, shall be resolved
solely and exclusively by final, binding and confidential arbitration through Judicial Arbitration & Mediation Services/Endispute, Inc. (“JAMS”) under the then existing JAMS arbitration rules. You understand and agree that this
provision waives your right to a jury trial on these claims. Any arbitration shall be held in San Francisco or San Mateo County unless otherwise agreed. Nothing in this section is intended to prevent either party from obtaining injunctive relief in
court to prevent irreparable harm pending the conclusion of any such arbitration. 
  
 21. RIGHT To WORK. As required by law, this Agreement is subject to satisfactory proof of your right to work in the United States. 
  
 If you choose to accept this Agreement under the terms described above,
please sign below and return this letter to me. 
  
 We look
forward to your favorable reply, and to a productive and enjoyable work relationship. 
  

	 Very truly yours,

	
	Renovis Neuroscience, Inc.
	
	 /s/    Lynne Zydowsky        

	 Dr. Lynne Zydowsky

	 President

  

	 Accepted and Agreed to by:

	
	 /s/    Tito Serafini        

	 Dr. Tito Serafini

  

 6Amendment to Employment Agreement, btwn the Registrant and Tito A. Serafini

 Exhibit 10.7 
  
 R  E  N  O  V  I  S 
 R E N E W . R E S T O R E . R E P A I R 
  
 May 1, 2003 
  
 Tito Serafini, Ph,D. 
  
 Re: Amendment to
Renovis, Inc. Employment Agreement 
  
 Dear Tito: 
  
 You and Renovis, Inc. (the “Company”) are parties to an Employment Agreement dated
July 1, 2000 (the “Employment Agreement”), which sets forth, among other things, the terms of your employment with the Company and certain severance benefits payable to you in the event of a qualifying termination of your employment. The
Company would like to amend the Employment Agreement as provided below to provide you with certain additional benefits in the event of a termination of your employment without Cause (as defined below) or your Constructive Termination (as defined
below). This letter agreement supersedes Section 13 of the Employment Agreement and any other agreement or policy to which the Company is a party with respect to any severance benefits payable to you and any acceleration of vesting of your stock
options or restricted stock as a result of your termination of employment. 
  
 1. Severance Benefits. 
  
 (a) Termination By
The Company Without Cause. If your employment by the Company is terminated by the Company without Cause (as defined below), or if there is a Constructive Termination (as defined below), at any time prior to the occurrence of a Change in Control
or more than thirteen (13) months following the occurrence of a Change in Control, and if you provide the Company with a signed general release of all claims, a form of which is set forth in Exhibit A to the Employment Agreement, the Company shall
provide you with the following severance benefits: (1) continuation of your base salary for a period of six (6) months after your termination date at the rate in effect immediately prior to your termination of employment, less applicable
withholdings, payable in installments pursuant to the Company’s normal and customary payroll procedures; (2) for the period beginning on your date of termination and ending on the date which is six (6) full months following your date of
termination (or, if earlier, the date on which you accept employment with another employer that provides comparable benefits), the Company shall pay for and provide you and your dependents with the same health benefits (e.g., medical and dental) to
which you would have been entitled had you remained continuously employed by the Company during such period, including, if necessary, paying the costs associated with continuation coverage pursuant to the Consolidated Omnibus Budget Reconciliation
Act of 1985, as amended (“COBRA”); and (3) on your date of termination, you shall immediately become vested with respect to those options to purchase the Company’s capital stock that you then hold that would have vested during the six
(6) month period following your date of termination and/or any restrictions with respect to restricted shares of the Company’s capital stock that you then hold that would have vested during the six (6) month period following your date of
termination shall immediately lapse. 
  
 RENOVIS,
INC. Ÿ 270 Littlefield Avenue, S. San Francisco, CA 94080 Ÿ Tel: 650.266.1400 Ÿ Fax 650.266.1460 Ÿ www. renovis.com 

 You understand and agree that you shall not be entitled to any other severance pay, severance benefits, or any other
compensation or benefits other than as set forth in this paragraph in the event of such a termination, other than as required under applicable law. 
  
 (b) Termination By The Company With Cause Or Termination By You. If your employment by the Company is terminated by the Company with Cause, or if
you voluntarily terminate your employment with the Company (other than pursuant to a Constructive Termination (as defined below)), you shall not be entitled to any severance pay, severance benefits, or any compensation or benefits from the Company
whatsoever, other than as required under applicable law. 
  
 (c) Termination Following Change in Control. If your employment by the Company is terminated by the Company without Cause (as defined below), or if there is a Constructive Termination (as defined below), in each case at any time
within thirteen (13) months following the occurrence of a Change in Control, and if you provide the Company with a signed general release of all claims, a form of which is set forth in Exhibit A to the Employment Agreement, the Company shall provide
you with the following severance benefits: (1) a lump sum payment equal to twelve (12) months of your base salary at the rate in effect immediately prior to the Change in Control, less applicable withholdings, to be paid by the Company within ten
(10) days of your date of termination; (2) for the period beginning on your date of termination and ending on the date which is twelve (12) full months following your date of termination (or, if earlier, the date on which you accept employment with
another employer that provides comparable benefits), the Company shall pay for and provide you and your dependents with the same health benefits (e.g., medical and dental) to which you would have been entitled had you remained continuously employed
by the Company during such period, including, if necessary, paying the costs associated with continuation coverage pursuant to COBRA; and (3) on your date of termination, you shall immediately become 100% vested with respect to any options to
purchase the Company’s capital stock that you then hold and/or any restrictions with respect to restricted shares of the Company’s capital stock that you then hold shall immediately lapse, and you shall be entitled to exercise any such
vested options until the expiration date of such options set forth in the stock option agreement(s) pursuant to which they were granted; provided, however, that if you are terminated by the Company following the effective date of a Change in
Control described in clause (d)(2)(b) below but accept employment with the Company’s successor or acquirer within thirty (30) days after the effective date of the Change in Control on terms and conditions not less favorable to you than those
contained in the Employment Agreement, you shall not be entitled to any severance benefits under this clause (c); provided, further, however, that if your employment and the Employment Agreement are thereafter terminated by the successor or
acquiror without Cause (as defined below), or if there is a Constructive Termination (as defined below), at any time within thirteen (13) months following the occurrence of the Change in Control, you shall be entitled to the severance benefits
described above in this clause (c). 

 You understand and agree that you shall not be entitled to any other severance pay, severance benefits, or any other
compensation or benefits other than as set forth in this paragraph in the event of such a termination, other than as required under applicable law. 
  
 (d) Definitions. 
  
 (1) Cause. For purposes of the Employment Agreement, the term “Cause” means: (i) theft, dishonesty or falsification of any employment or
Company records; (ii) malicious or reckless disclosure of the Company’s confidential or proprietary information; (iii) commission of any immoral or illegal act or any gross or willful misconduct, where the Company reasonably determines that
such act or misconduct has (A) seriously undermined the ability of the Company’s management to entrust you with important matters or otherwise work effectively with you, (B) contributed to the Company’s loss of significant revenues or
business opportunities, or (C) significantly and detrimentally effected the business or reputation of the Company or any of its subsidiaries; and/or (iv) the failure or refusal by you to work diligently to perform tasks or achieve goals reasonably
requested by the Board, provided such failure or refusal continues after the receipt of reasonable notice in writing of such failure or refusal and an opportunity to correct the problem. “Cause” shall not mean a physical or mental
disability. 
  
 (2) Change in Control. For purposes
of the Employment Agreement, the term “Change in Control” means the consummation of any of the following transactions: 
  
 a. the closing of a business combination (such as a merger or consolidation) of the Company with any other corporation or other type of business
entity (such as a limited liability company), other than a business combination which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being
converted into voting securities of the surviving entity) at least fifty percent (50%) of the total voting power represented by the voting securities of the Company or such controlling surviving entity outstanding immediately after such business
combination; or 
  
 b. the sale, lease, exchange or other
transfer or disposition by the Company of all or substantially all (more than seventy percent (70%)) of the Company’s assets by value; or 
  
 c. an acquisition of any voting securities of the Company by any “person” (as the term “person” is used for purposes of
Section 13(d) or Section 14(d) of the Securities Exchange Act of 1934, as amended (the “1934 Act”)) immediately after which such person has “beneficial ownership” (within the meaning of Rule 13d-3 promulgated under the 1934 Act)
of fifty percent (50%) or more of the combined voting power of the Company’s then outstanding voting securities. 
  
 (3) Constructive Termination. For purposes of the Employment Agreement, the term “Constructive Termination” means your resignation
within sixty (60) days of one or more of the following events which remains uncured thirty (30) days after your delivery of written notice thereof: 

 a. the delegation to you of duties or the reduction of your duties, either of which substantially
reduces the nature, responsibility, or character of your position immediately prior to such delegation or reduction; 
  
 b. a material reduction by the Company in your base salary in effect immediately prior to such reduction; 
  
 c. a material reduction by the Company in the kind or level of
employee benefits or fringe benefits to which you were entitled prior to such reduction; or the taking of any action by the Company that would adversely affect your participation in any plan, program or policy generally applicable to employees of
equivalent seniority; and 
  
 d. the Company’s
requiring you to relocate your office to a place more than forty (40) miles from its present location (except that required travel on the Company’s business to an extent substantially consistent with your present business travel obligations
shall not be considered a relocation).” 
  
 2. Effect of Amendment. On
and after the date hereof, each reference in this letter agreement or the Employment Agreement to the “Employment Agreement” shall mean the Employment Agreement as amended hereby. Except as specifically amended above, the Employment
Agreement shall remain in full force and effect and is hereby ratified and confirmed. 
  
 3. Entire Agreement. This letter agreement, together with the Employment Agreement, constitute the entire agreement between you and the Company relating to the terms and conditions of your employment specified
herein and therein. 
  
 If the terms of this letter agreement are
acceptable to you, please sign below and return this letter to Paula Serbin 
  

	 Very truly yours,

	
	Renovis, Inc.
	
	 /s/    Corey Goodman

	 Corey Goodman, Ph.D.

	 President & Chief Executive Officer

  

	Accepted and Agreed to by:
	
	 /s/    Tito Serafini

	 Tito Serafini, Ph.D

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