Document:

Stockholder Voting Agreement dated March 28, 2004

 EXHIBIT 10.1 
  
  
 STOCKHOLDER VOTING AGREEMENT 

 
  
 BY AND BETWEEN 
  
 AMGEN INC. 
  
 AND 
  
 The Stockholders Identified on Schedule A attached hereto 
  
  
 Dated as of March 28, 2004 

 STOCKHOLDER VOTING AGREEMENT 
  
 This STOCKHOLDER VOTING AGREEMENT (this “Agreement”) is entered into as of March 28, 2004, by and among
Amgen Inc., a Delaware corporation (“Parent”), and the Stockholders of Tularik Inc., a Delaware corporation (the “Company”) identified on Schedule A attached hereto (each a “Stockholder” and
collectively, the “Stockholders”). 
  
 W I T N E S
S E T H: 
  
 WHEREAS, as of the date hereof, each Stockholder
“beneficially owns” (as such term is defined in Rule 13d-3 promulgated under the Securities Exchange Act of 1934, as amended) and is entitled to dispose of (or to direct the disposition of) and to vote (or to direct the voting of) that
total number of shares of common stock, par value $0.001 per share (the “Common Stock”) of the Company as are set forth adjacent to such Stockholder’s name on Schedule A attached hereto (the “Owned
Shares”), as such shares may be adjusted after the date hereof by stock dividend, stock split, recapitalization, combination, merger, consolidation, reorganization or other change in the capital structure of the Company affecting the Common
Stock (such shares of Common Stock, together with any other shares of Common Stock the voting power over which is acquired by a Stockholder during the period from and including the date hereof through and including the date on which this Agreement
is terminated in accordance with its terms, are collectively referred to herein as the “Subject Shares”); 
  
 WHEREAS, Parent, Arrow Acquisition, LLC, a Delaware limited liability company wholly-owned by Parent (“Merger Sub”), and the Company
propose to enter into an Agreement and Plan of Merger, dated as of the date hereof (the “Merger Agreement”), pursuant to which the Company will merge with and into Merger Sub, with Merger Sub surviving as a limited liability company
wholly-owned by Parent (the “Merger”); and 
  
 WHEREAS, as a condition to the willingness of Parent to enter into the Merger Agreement, and as an inducement and in consideration therefor, Parent has required that the Stockholders agree, and the Stockholders have agreed, to enter into
this Agreement. 
  
 NOW, THEREFORE, in consideration of the
foregoing and the mutual premises, representations, warranties, covenants and agreements contained herein, the parties hereto, intending to be legally bound, hereby agree as follows: 
  
 ARTICLE I 
 DEFINITIONS 
  
 Section 1.1 Capitalized
Terms. For purposes of this Agreement, capitalized terms used and not defined herein shall have the respective meanings ascribed to them in the Merger Agreement. 
  
 ARTICLE II 
 VOTING AGREEMENT AND IRREVOCABLE PROXY 
  
 Section 2.1 Agreement to Vote the Subject Shares. Each Stockholder, in its capacity as such, hereby agrees that, during the period commencing on the date hereof and 

 continuing until the termination of this Agreement (such period, the “Voting Period”), at any meeting
(or any adjournment or postponement thereof) of the holders of any class or classes of the capital stock of the Company, however called, or in connection with any written consent of the holders of any class or classes of the capital stock of the
Company, such Stockholder shall vote or cause to be voted the Subject Shares (x) in favor of the approval of the terms of the Merger Agreement, the Merger and the other transactions contemplated by the Merger Agreement (and any actions required in
furtherance thereof), (y) against any action, proposal, transaction or agreement that would result in a breach in any respect of any covenant, representation or warranty or any other obligation or agreement of the Company under the Merger Agreement
or of such Stockholder contained in this Agreement, and (z) except as otherwise agreed to in writing in advance by Parent, against the following actions or proposals: (i) any Acquisition Proposal; and (ii) (A) any change in the persons who
constitute the board of directors of the Company that has not been previously approved by at least a majority of the persons who were directors of the Company as of the date of this Agreement (or their successors who were so approved); (B) any
change in the present capitalization of the Company or any amendment of the Company’s articles of incorporation or bylaws; (C) any other material change in the Company’s corporate structure or business; or (D) any other action or proposal
involving the Company or any of its subsidiaries that is intended, or could reasonably be expected, to prevent, impede, interfere with, delay, postpone or adversely affect the transactions contemplated by the Merger Agreement; provided, however,
nothing in this Agreement shall be interpreted as obligating the Stockholders to exercise any options to acquire shares of Common Stock. Any such vote shall be cast or consent shall be given in accordance with such procedures relating thereto so
as to ensure that it is duly counted for purposes of determining that a quorum is present and for purposes of recording the results of such vote or consent. During the Voting Period, each Stockholder agrees not to enter into any agreement,
commitment, letter of intent, agreement in principle, or understanding with any Person that violates or conflicts with or could reasonably be expected to violate or conflict with the provisions and agreements contained in this Agreement. 

 
 Section 2.2 Grant of Irrevocable Proxy. Each Stockholder
hereby appoints Parent and any designee of Parent, and each of them individually, as such Stockholder’s proxy and attorney-in-fact, with full power of substitution and resubstitution, to cause such Stockholder’s shares to be counted as
present at any meeting of the Company’s stockholders during the Voting Period and to vote or act by written consent during the Voting Period with respect to the Subject Shares in accordance with Section 2.1. This proxy is given to secure the
performance of the duties of such Stockholder under this Agreement. Each Stockholder shall promptly cause a copy of this Agreement to be deposited with the Company at its principal place of business. Each Stockholder shall take such further action
or execute such other instruments as may be necessary to effectuate the intent of this proxy. Each Stockholder hereby revokes all other proxies and powers of attorney with respect to its Subject Shares that it may have previously granted, in each
case to the extent such prior or subsequent proxies or powers of attorney would prevent such Stockholder from complying with such Stockholder’s obligations under this Agreement. 
  
 Section 2.3 Nature of Irrevocable Proxy. The proxy and power of attorney granted pursuant to Section 2.2 by
Stockholder shall be irrevocable during the Voting Period, shall be deemed to be coupled with an interest sufficient in law to support an irrevocable proxy and shall revoke any and all prior proxies granted by such Stockholder. The power of attorney
granted by 
  

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 each Stockholder herein is a durable power of attorney and shall survive the dissolution, bankruptcy, death or incapacity
of such Stockholder. The proxy and power of attorney granted hereunder shall terminate upon the termination of this Agreement pursuant to Section 6.1. 
  
 Section 2.4 Legend. To the extent a Stockholder’s Subject Shares are in certificated form, such Stockholder shall promptly cause such
certificate representing its Subject Shares to be surrendered and shall instruct the transfer agent for the Subject Shares to cause the following legend to be conspicuously noted thereon: 
  
 “THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A STOCKHOLDER VOTING AGREEMENT DATED AS OF MARCH 28, 2004.
THE STOCKHOLDER VOTING AGREEMENT RESTRICTS THE TRANSFERABILITY OF THE SHARES REPRESENTED BY THIS CERTIFICATE AND INCLUDES A VOTING AGREEMENT AND AN IRREVOCABLE PROXY TO VOTE THE SHARES REPRESENTED BY THIS CERTIFICATE.” 
  
 To the extent a Stockholder’s Subject Shares are not in certificated
form, such Stockholder shall, upon the request of Parent, use its best efforts to promptly obtain certificates representing Subject Shares that are currently uncertificated and shall promptly thereafter cause such certificates to be surrendered and
shall instruct the transfer agent for the Subject Shares to cause the foregoing legend to be conspicuously noted thereon. 
  
 ARTICLE III 
 COVENANTS

  
 Section 3.1 Generally. Each Stockholder
agrees that during the Voting Period, except as contemplated by the terms of this Agreement, it shall not (i) sell, transfer, tender, pledge, encumber, assign or otherwise dispose of (collectively, a “Transfer”), or enter into any
contract, option or other agreement with respect to, or consent to, a Transfer of, any or all of the Subject Shares, (ii) grant any proxy, power of attorney, or other authorization in or with respect to the Subject Shares, or (iii) take any action
that would have the effect of preventing, impeding, interfering with or adversely affecting its ability to perform its obligations under this Agreement; provided, however, the parties agree and acknowledge that certain of the Subject Shares,
as identified on Schedule B hereto, have been previously been pledged to the Company pursuant to certain stock pledge agreements and as security for certain loan agreements between the Company and the Stockholders; provided further,
David V. Goeddel shall be permitted to transfer those Subject Shares beneficially owned by him to any trust, beneficiary, administrator, custodian or otherwise for estate planning purposes, provided that such transferee enters into a written
agreement in favor Parent agreeing to be bound by the terms and conditions of this Agreement. 
  
 Section 3.2 Standstill Obligations of Stockholders. Each Stockholder covenants and agrees with Parent that, during the Voting Period: 
  
 (a) Such Stockholder shall not, nor shall such Stockholder permit any of its controlled Affiliates to, nor shall such
Stockholder act in concert with or permit any of its controlled Affiliates to act in concert with any Person to make, or in any manner participate in, 
  

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 directly or indirectly, a “solicitation” of “proxies” (as defined in the rules and regulations of the
Securities and Exchange Commission) or powers of attorney or similar rights to vote, or seek to advise or influence any Person with respect to the voting of, any shares of Common Stock in connection with any vote or other action on any matter, other
than to recommend that stockholders of the Company vote in favor of the Merger and the Merger Agreement and otherwise as expressly provided by Article II of this Agreement. 
  
 (b) Such Stockholder shall not, nor shall such Stockholder permit any of its controlled Affiliates to, nor shall such
Stockholder act in concert with or permit any of its controlled Affiliates to act in concert with any Person to, deposit any shares of Common Stock in a voting trust or subject any shares of Common Stock to any arrangement or agreement with any
Person with respect to the voting of such shares of Common Stock, except as provided by Article II of this Agreement. 
  
 (c) Such Stockholder shall not, and shall cause its Representatives not to, directly or indirectly: (i) solicit, initiate or induce or knowingly or
intentionally facilitate or encourage any inquiry with respect to, or the making, submission or announcement of, any Acquisition Proposal or any proposal that would reasonably be expected to lead to any Acquisition Proposal, (ii) furnish to any
Person other than Parent, Merger Sub or their Affiliates any information with respect to any proposal that constitutes or would reasonable be expected to lead to any Acquisition Proposal, (iii) participate or engage in discussions or negotiations
with any Person with respect to any Acquisition Proposal, except to notify such Person as to the existence of these provisions, or (iv) enter into any letter of intent or similar document or any agreement, commitment or understanding contemplating
or otherwise relating to any Acquisition Proposal or a transaction contemplated thereby; provided, however, that in connection with Acquisition Proposals as to which Parent has received a Superior Proposal Notice, such Stockholder may provide
information and engage in discussions to the same extent as the Company is so permitted pursuant to Section 6.4(c) of the Merger Agreement. Each Stockholder hereby represents that it is not now engaged in discussions or negotiations with any party
other than Parent with respect to any Acquisition Proposal. Each Stockholder shall (i) promptly notify Parent (orally and in writing) if any offer is made to such Stockholder, any discussions or negotiations are sought to be initiated with such
Stockholder, any inquiry, proposal or contact is made or any information is requested from such Stockholder with respect to any Acquisition Proposal, (ii) promptly notify Parent of the terms of any proposal that such Stockholder may receive in
respect of any Acquisition Proposal, and the identity of the prospective purchaser, (iii) promptly provide Parent with a copy of any such offer, if written, or a written summary of such offer, if not in writing, and (iv) promptly keep Parent
informed in all material respects of the status and details (including material amendments or proposed material amendments) of any such Acquisition Proposal of which such Stockholder is aware. 
  
 ARTICLE IV 
 REPRESENTATIONS AND WARRANTIES OF STOCKHOLDER 
  
 Each Stockholder hereby represents and warrants to Parent as follows: 
  
 Section 4.1 Authority. Such Stockholder has all legal capacity and authority to execute and deliver this
Agreement and to consummate the transactions contemplated hereby. 
  

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 This Agreement has been duly executed and delivered by such Stockholder and constitutes a valid and binding obligation of
such Stockholder, enforceable in accordance with its terms. 
  
 Section 4.2 Ownership of Shares. As of the date hereof, such Stockholder is the lawful owner of the Owned Shares and has the sole power to vote (or cause to be voted) and dispose of such shares of Common Stock. Such
Stockholder holds that number of certificated Owned Shares and uncertificated Owned Shares, in each case, as identified on Schedule A hereto. Other than the Subject Shares and options to purchase Common Stock, as identified on Schedule
A (which Schedule identifies any such exception by Stockholder), such Stockholder does not own or hold any right to acquire any additional shares of any class of capital stock of the Company or other securities of the Company or any interest
therein or any voting rights with respect to any securities of the Company. The Subject Shares are not subject to any voting trust agreement or other contracts, agreement, arrangement, commitment or understanding to which such Stockholder is party
restricting or otherwise relating to the voting, dividend rights or disposition of the Subject Shares. Except as set forth on Schedule B hereto (which Schedule identifies any such exception by Stockholder), such Stockholder has good and valid
title to the Owned Shares, free and clear of any and all pledges, mortgages, liens, charges, proxies, voting agreements, encumbrances, adverse claims, options, security interests and demands of any nature or kind whatsoever, other than those created
by this Agreement. 
  
 Section 4.3 No Conflicts. (i)
No filing with any Governmental Entity, and no authorization, consent or approval of any other Person is necessary for the execution of this Agreement by such Stockholder and the consummation by such Stockholder of the transactions contemplated
hereby and (ii) none of the execution and delivery of this Agreement by such Stockholder, the consummation by such Stockholder of the transactions contemplated hereby or compliance by such Stockholder with any of the provisions hereof shall (A)
result in, or give rise to, a violation or breach of or a default under any of the terms of any material contract, understanding, agreement or other instrument or obligation to which such Stockholder is a party or by which such Stockholder or any of
its Subject Shares or assets may be bound, or (B) violate any applicable Law which could reasonably be expected to adversely affect such Stockholder’s ability to perform its obligations under this Agreement. 
  
 Section 4.4 Reliance by Parent. Such Stockholder understands
and acknowledges that Parent is entering into the Merger Agreement in reliance upon the execution and delivery of this Agreement by such Stockholder. 
  
 ARTICLE V 
 REPRESENTATIONS AND
WARRANTIES OF PARENT 
  
 Parent hereby represents and warrants
to each Stockholder as follows: 
  
 Section 5.1 Due
Organization, etc. Parent is a company duly organized and validly existing under the laws of the jurisdiction of its incorporation. Parent has all necessary corporate power and authority to execute and deliver this Agreement and to consummate
the transactions contemplated hereby. The execution and delivery of this Agreement and the consummation of the transactions contemplated hereby by Parent have been duly authorized by all necessary corporate action on the part of Parent. 

 

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 Section 5.2 Conflicts. (i) No filing with any Governmental Entity, and no authorization,
consent or approval of any other Person is necessary for the execution of this Agreement by Parent and the consummation by Parent of the transactions contemplated hereby and (ii) none of the execution and delivery of this Agreement by Parent, the
consummation by Parent of the transactions contemplated hereby shall (A) conflict with or result in any breach of the organizational documents of Parent, (B) result in, or give rise to, a violation or breach of or a default under any of the terms of
any material contract, understanding, agreement or other instrument or obligation to which Parent is a party or by which Parent or any of its assets may be bound, or (C) violate any applicable Law, which could reasonably be expected to adversely
affect Parent’s ability to perform its obligations under this Agreement. 
  
 ARTICLE VI 
 TERMINATION 
  
 Section 6.1 Termination. This Agreement shall terminate, and neither Parent nor any Stockholder shall have any
rights or obligations hereunder and this Agreement shall become null and void and have no effect upon the earliest to occur of (i) the mutual consent of Parent and the Stockholders to terminate this Agreement, (ii) the Effective Time, (iii) the date
of termination of the Merger Agreement in accordance with its terms and (iv) the date of any modification, waiver or amendment to the Merger Agreement in a manner that materially reduces the Merger Consideration; provided, however,
that the termination of this Agreement shall not prevent any party hereunder from seeking any remedies (at law or in equity) against any other party hereto for such party’s breach of any of the terms of this Agreement. Notwithstanding the
foregoing, Section 7.1 and Sections 7.4 through 7.18, inclusive, of this Agreement shall survive the termination of this Agreement. 
  
 ARTICLE VII 
 MISCELLANEOUS

  
 Section 7.1 Appraisal Rights. To the extent
permitted by applicable law, each Stockholder hereby waives any rights of appraisal or rights to dissent from the Merger that it may have under applicable law. 
  

Section 7.2 Publication. 
  
 (a) Each Stockholder agrees that, during the Voting Period, such Stockholder shall not issue any public release or announcement concerning the
transactions contemplated by this Agreement and the Merger Agreement without the prior consent of Parent (which consent shall not be unreasonably withheld), except as such release or announcement may, upon the advice of such Stockholder’s
counsel, be required by applicable Law, in which case such Stockholder shall allow Parent reasonable time to comment on such release or announcement in advance of such issuance and shall cause only the minimum amount of information to be disclosed
as is required by applicable Law. 
  
 (b) Each Stockholder hereby
permits Parent, Merger Sub and/or the Company to publish and disclose in press releases, Schedule 13D filings, and the Registration Statement and/or the Proxy Statement/Prospectus (including all documents and schedules filed with the 
  

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 Securities and Exchange Commission) and any other disclosures or filings required by applicable Law, its identity and
ownership of shares of the Common Stock, the nature of its commitments, arrangements and understandings pursuant to this Agreement and/or the text of this Agreement. 
  
 Section 7.3 HSR Requirements. Each Stockholder agrees promptly to make all necessary filings, if any, and
thereafter make any other required submissions, if any, with respect to the Merger Agreement, the Merger and the transactions contemplated by the Merger Agreement required under the HSR Act, any antitrust and competition Laws of any other applicable
jurisdiction and any other applicable Law. Each Stockholder shall cooperate with Parent in connection with the making of any such filings referenced in the preceding sentence, including providing copies of all such documents to Parent and its
advisors prior to filing and, if requested, to accept all reasonable additions, deletions or changes suggested in connection therewith. 
  
 Section 7.4 Affiliate Letter. Each Stockholder has executed and delivered to Parent an affiliate letter in substantially the form attached
hereto as Exhibit 7.4. 
  
 Section 7.5 Further
Actions. Each of the parties hereto agrees that it will use its reasonable best efforts to do all things reasonably necessary to effectuate this Agreement. 
  

Section 7.6 Fees and Expenses. Except as otherwise provided in the Merger Agreement, each of the parties shall be responsible for its own
fees and expenses (including, without limitation, the fees and expenses of financial consultants, investment bankers, accountants and counsel) in connection with the entering into of this Agreement and the consummation of the transactions
contemplated hereby and the Merger Agreement, regardless of whether the Merger is consummated. 
  
 Section 7.7 Amendments, Waivers, etc. This Agreement may not be amended, changed, supplemented, waived or otherwise modified, except upon the execution and delivery of a written agreement executed by
each of the parties hereto. The failure of any party hereto to exercise any right, power or remedy provided under this Agreement or otherwise available in respect hereof at law or in equity, or to insist upon compliance by any other party hereto
with its obligations hereunder, and any custom or practice of the parties at variance with the terms hereof shall not constitute a waiver by such party of its right to exercise any such or other right, power or remedy or to demand such compliance.

  
 Section 7.8 Specific Performance. Each
Stockholder acknowledges that irreparable damage would occur and that it will be impossible to measure in money the damage to Parent and Merger Sub if such Stockholder fails to comply with the obligations imposed by this Agreement, and that, in the
event of any such failure, Parent and Merger Sub will not have an adequate remedy at law or in damages. Accordingly, each Stockholder agrees that injunctive relief or any other equitable remedy, in addition to any remedies at law or damages, is the
appropriate remedy for any such failure and will not oppose the granting of any such remedy on the basis that Parent or Merger Sub has an adequate remedy at law. Each Stockholder agrees not to seek, and agrees to waive any requirement for, the
securing or posting of a bond in connection with Parent seeking or obtaining such equitable relief. 
  

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 Section 7.9 Notices. Any notices or other communications required or permitted under, or
otherwise in connection with this Agreement shall be in writing and shall be deemed to have been duly given when delivered in person or upon confirmation of receipt when transmitted by facsimile transmission (with confirmation) or on receipt after
dispatch by registered or certified mail, postage prepaid, addressed, or on the next Business Day if transmitted by national overnight courier, in each case as follows: 
  
 If to Parent or Merger Sub, addressed to it at: 
  
 Amgen Inc. 
 One Amgen Center Drive 
 Thousand Oaks, Ca 91320-1799 
 Fax: (805) 499-8011 
 Attn: Corporate Secretary 
  
 with a copy to: 
  
 Latham &
Watkins LLP 
 650 Town Center Drive 
 Costa Mesa, Ca 92626 
 Fax: (714) 755-8290 
 Attn: Charles K. Ruck 
  
 If to a Stockholder: addressed to such Stockholder as set forth on Schedule A 
  
 with a copy to: 
  
 Cooley Godward LLP 
 Five Palo Alto Square 
 3000 El Camino Real 
 Palo Alto, Ca 94306 
 Fax: (650) 849-7400 
 Attn: Suzanne Hooper, Esq. 
  
 Section 7.10 Headings. The headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning or interpretation of this Agreement. 
  
 Section 7.11 Severability. If any term or other provision of
this Agreement is invalid, illegal or incapable of being enforced by any rule of Law or public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal
substance of the transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall
negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that transactions contemplated hereby are fulfilled to the extent possible. 
  

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 Section 7.12 Entire Agreement. This Agreement (together with the Merger Agreement, to the
extent referred to herein) constitutes the entire agreement of the parties and supersedes all prior agreements and undertakings, both written and oral, between the parties, or any of them, with respect to the subject matter hereof.

  
 Section 7.13 Assignment. This Agreement shall
not be assigned by operation of law or otherwise without the prior written consent of each of the parties, except that Parent may assign and transfer its rights and obligations hereunder to any entity that is wholly owned, directly or indirectly, by
Parent. 
  
 Section 7.14 Certain Events. Stockholder
agrees that this Agreement and the obligations hereunder shall attach to the Subject Shares and shall be binding upon any Person or entity to which legal or beneficial ownership of such Subject Shares shall pass, whether by operation of law, or
otherwise. 
  
 Section 7.15 Parties in Interest.
This Agreement shall be binding upon and inure solely to the benefit of each party hereto and their respective successors and assigns, and nothing in this Agreement, express or implied, is intended to or shall confer upon any other Person any right,
benefit or remedy of any nature whatsoever under or by reason of this Agreement. 
  
 Section 7.16 Mutual Drafting. Each party hereto has participated in the drafting of this Agreement, which each party acknowledges is the result of extensive negotiations between the parties. 

 
 Section 7.17 Governing Law; Consent to Jurisdiction; Waiver of
Trial by Jury.  
  
 (a) This Agreement and the
transactions contemplated hereby, and all disputes between the parties under or related to the Agreement or the facts and circumstances leading to its execution, whether in contract, tort or otherwise, shall be governed by and construed in
accordance with the laws of the State of Delaware, without regard to the application of Delaware principles of conflicts of laws. 
  
 (b) Each of the parties hereto hereby irrevocably and unconditionally submits, for itself and its property, to the exclusive jurisdiction of any Delaware
State court, or Federal court of the United States of America, sitting in Delaware, and any appellate court from any thereof, in any action or proceeding arising out of or relating to this Agreement or the agreements delivered in connection herewith
or the transactions contemplated hereby or thereby or for recognition or enforcement of any judgment relating thereto, and each of the parties hereby irrevocably and unconditionally (i) agrees not to commence any such action or proceeding except in
such courts, (ii) agrees that any claim in respect of any such action or proceeding may be heard and determined in such Delaware State court or, to the extent permitted by law, in such Federal court, (iii) waives, to the fullest extent it may
legally and effectively do so, any objection which it may now or hereafter have to the laying of venue of any such action or proceeding in any such Delaware State or Federal court, and (iv) waives, to the fullest extent permitted by law, the defense
of an inconvenient forum to the maintenance of such action or proceeding in any such Delaware State or Federal court. Each of the parties hereto agrees that a final judgment in any such action or proceeding shall be conclusive and may be enforced in
other jurisdictions by suit 
  

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 on the judgment or in any other manner provided by law. Each party to this Agreement irrevocably consents to service of
process in the manner provided for notices in Section 7.9. Nothing in this Agreement shall affect the right of any party to this Agreement to serve process in any other manner permitted by law. 
  
 (c) EACH PARTY ACKNOWLEDGES AND AGREES THAT ANY CONTROVERSY WHICH MAY ARISE
UNDER THIS AGREEMENT IS LIKELY TO INVOLVE COMPLICATED AND DIFFICULT ISSUES, AND THEREFORE IT HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF OR
RELATING TO THIS AGREEMENT AND ANY OF THE AGREEMENTS DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY. EACH PARTY CERTIFIES AND ACKNOWLEDGES THAT (I) NO REPRESENTATIVE, AGENT OR ATTORNEY OF ANY OTHER PARTY HAS
REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE EITHER OF SUCH WAIVERS, (II) IT UNDERSTANDS AND HAS CONSIDERED THE IMPLICATIONS OF SUCH WAIVERS, (III) IT MAKES SUCH WAIVERS
VOLUNTARILY, AND (IV) IT HAS BEEN INDUCED TO ENTER INTO THIS AGREEMENT BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 7.16(c). 
  
 Section 7.18 Counterparts. This Agreement may be executed in one or more counterparts, and by the different parties hereto in separate
counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same agreement. 
  
 * * * * * 
  
  

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 IN WITNESS WHEREOF, Parent and the Stockholders have caused this Agreement to be duly executed as of the
day and year first above written. 
  

			
	 AMGEN INC.,
 a Delaware
corporation
  

		
	By:	  	/s/    DAVID J. SCOTT
	 	 	

	 	  	 David J. Scott
 Senior Vice President, General Counsel
and Secretary

			
	 STOCKHOLDERS
  

		
	By:	  	/s/    DAVID V. GOEDDEL
	 	 	

	 	  	Name: David V. Goeddel

  

			
		
	By:	  	/s/    A. GRANT HEIDRICH, III
	 	 	

	 	  	Name: A. Grant Heidrich, III

  

			
		
	By:	  	/s/    EDWARD R. MCCRACKEN
	 	 	

	 	  	Name: Edward R. McCracken

  

			
		
	By:	  	/s/    STEVEN L. MCKNIGHT
	 	 	

	 	  	Name: Steven L. McKnight

  

			
		
	By:	  	/s/    CRAIG A. P. D. SAXTON
	 	 	

	 	  	Name: Craig A. P. D. Saxton

  

			
		
	By:	  	/s/    ANDREW J. PERLMAN
	 	 	

	 	  	Name: Andrew J. Perlman

  

			
		
	By:	  	/s/    TERRY ROSEN
	 	 	

	 	  	Name: Terry Rosen

			
		
	By:	  	/s/    WILLIAM J. RIEFLIN
	 	 	

	 	  	Name: William J. Rieflin

  

			
		
	By:	  	/s/    JACK M. ANTHONY
	 	 	

	 	  	Name: Jack M. Anthony

  

			
		
	By:	  	/s/    MICHAEL D. LEVY
	 	 	

	 	  	Name: Michael D. Levy

  

			
		
	By:	  	/s/    EDWARD W. HOLMES
	 	 	

	 	  	Name: Edward W. Holmes

 Schedule A 
  

											
	 Stockholder

	  	Total Number
of Shares of
Owned Shares

	  	Certificated
Shares

	  	Options to
Purchase
Common
Stock

	  	Uncertificated
Shares

	  	 Address

	 David V. Goeddel
	  	2,086,629	  	2,033,334	  	941,666	  	53,295 	  	2115 Forest View Avenue, Hillsborough CA 94010 
	 A. Grant Heidrich, III
	  	153,245	  	129,167	  	36,000	  	24,078	  	The Mayfield Fund, 2800 Sand Hill Road, Menlo Park, CA 94025
	 Edward W. Holmes
	  	0	  	0	  	35,000	  	0	  	UCSD, 9500 Gilman Drive, La Jolla, CA 92093-0602
	 Edward R. McCracken
	  	70,512	  	26,000	  	26,000	  	44,512	  	PO Box 1316, Angel Fire, NM 87710
	 Steven L. McKnight
	  	310,016	  	37,520	  	244,000	  	272,496	  	Dept of Biology, UTX SW Medical Center, Room L3.214, 5323 Harry Hines Blvd., Dallas, TX 75390-9152
	 Craig A. P. D. Saxton
	  	25,000	  	0	  	45,000	  	25,000	  	628 Hamburg Road, Lyme, CT 06371
	 Andrew J. Perlman
	  	352,588	  	320,754	  	380,288	  	31,834	  	618 Mirada Avenue, Stanford, CA 94305
	 Terry Rosen
	  	138,993	  	136,626	  	624,666	  	2,367	  	2820 Adeline, Burlingame CA 94010
	 William J. Rieflin
	  	221,052	  	205,362	  	469,999	  	15,690	  	1225 La Canada Road, Hillsborough, CA 94010
	 Jack M. Anthony
	  	17,492	  	0	  	150,000	  	17,492	  	21 Crestview Circle, S. San Francisco, CA 94080
	 Michael D. Levy
	  	10,178	  	0	  	400,000	  	10,178	  	1200 Tournament Drive, Hillsborough, CA 94010

 Schedule B 
  

			
	 Stockholder

	  	Number of Owned
Shares Pledged
to the Company

	 Terry Rosen
	  	138,993
	 Michael D. Levy
	  	10,178

  

 2 

 Exhibit 7.4 
  
 FORM OF AFFILIATE LETTER 
  
             , 2004 
  
 Amgen Inc. 
 Amgen Center Drive 
 Thousand Oaks, CA 91320-1799 
  
 Ladies and Gentlemen: 
  
 The
undersigned has been advised that, as of the date of this letter, the undersigned may be deemed to be an “affiliate” of Tularik Inc., a Delaware corporation (“Tularik”), as the term “affiliate” is defined for purposes
of paragraphs (c) and (d) of Rule 145 (“Rule 145”) of the rules and regulations (the “Rules and Regulations”) of the Securities and Exchange Commission (the “Commission”) under the Securities Act of 1933, as amended
(the “Act”). Pursuant to the terms of the Agreement and Plan of Merger dated as of March 28, 2004 (the “Agreement”) by and among Tularik, Amgen Inc., a Delaware corporation (“Amgen”), and Arrow Acquisition, LLC, a
limited liability company (“Merger Sub”), Tularik will be merged with Merger Sub (the “Merger”). 
  
 As a result of the Merger, the undersigned will receive shares of common stock, par value $.0001 per share, of Amgen (“Amgen Common Stock”) in
exchange for shares of common stock, par value $.001 per share, of Tularik (“Tularik Common Stock”) owned by the undersigned. 
  
 The undersigned recognizes that Tularik, Amgen and the Surviving Entity (as defined in the Agreement) will rely upon this letter in consummating the
Merger. 
  
 1. Compliance with the Act. The undersigned
represents, warrants and covenants that: 
  
 (a)
The undersigned shall not make any sale, transfer or other disposition of Amgen Common Stock in violation of the Act or the Rules and Regulations. 
  
 (b) The undersigned has carefully read this letter and discussed its requirements and other applicable limitations upon the
undersigned’s ability to sell, transfer or otherwise dispose of Amgen Common Stock, to the extent the undersigned felt necessary, with the undersigned’s counsel or counsel for Tularik. 
  
 (c) The undersigned has been advised that the issuance of
Amgen Common Stock to the undersigned pursuant to the Agreement will be registered with the Commission under the Act on a Registration Statement on Form S-4. However, the undersigned has also been advised that, because the undersigned may be deemed
to have been an affiliate of Tularik at the time the Merger was submitted for a vote of the 
  

 3 

 stockholders of Tularik, and the distribution by the undersigned of Amgen Common Stock has not been
registered under the Act, the undersigned may not sell, transfer or otherwise dispose of Amgen Common Stock issued to the undersigned in the Merger unless (i) such sale, transfer or other disposition has been registered under the Act, (ii) such
sale, transfer or other disposition is made in conformity with Rule 145, or (iii) in the opinion of outside counsel, which opinion and outside counsel are reasonably acceptable to Amgen, or pursuant to a “no action” or interpretative
letter obtained by the undersigned from the staff of the Commission, such sale, transfer or other disposition is otherwise exempt from registration under the Act. 
  
 (d) The undersigned understands that Rule 145 permits offers, sales and transfers only in limited amounts
and in limited circumstances, many of which will be outside of the undersigned’s control. The undersigned understands that Amgen is under no obligation to register the sale, transfer or other disposition of Amgen Common Stock by the undersigned
or on the undersigned’s behalf under the Act or to take any other action necessary in order to make compliance with an exemption from such registration available. 
  
 (e) In the event of a sale, transfer or other disposition of Amgen Common Stock pursuant to Rule 145, the
undersigned will supply Amgen with a letter in the form of Exhibit A hereto evidencing compliance with such Rule and an opinion in form and substance reasonably satisfactory to Amgen from outside counsel reasonably satisfactory to Amgen to
the effect that such sale, transfer or other disposition is not in violation of the Act or the Rules and Regulations. The undersigned understands that Amgen may instruct its transfer agent to withhold the transfer of any shares of Amgen Common Stock
disposed of by the undersigned, but that upon receipt of such letter the transfer agent shall effectuate the transfer of such shares indicated as sold, transferred or otherwise disposed of in the letter. 
  
 (f) The undersigned also understands that there will be
placed on any certificates for Amgen Common Stock issued to the undersigned, or any substitutions therefor, a legend stating in substance: 
  
 “THE SHARES REPRESENTED BY THIS CERTIFICATE WERE ISSUED IN A TRANSACTION TO WHICH RULE 145 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED,
APPLIES AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR IN ACCORDANCE WITH AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED.” 

 
 (g) The undersigned also understands that unless the
transfer by the undersigned of the undersigned’s Amgen Common Stock has been registered under the Act or is a sale made in conformity with Rule 145, Amgen reserves the right to put the following legend on the certificates issued to the
undersigned’s transferee: 
  

 4 

 “THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED, AND WERE ACQUIRED FROM A PERSON WHO RECEIVED SUCH SHARES IN A TRANSACTION TO WHICH RULE 145 PROMULGATED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, APPLIES. THE SHARES HAVE BEEN ACQUIRED BY THE HOLDER NOT WITH A VIEW TO, OR FOR
RESALE IN CONNECTION WITH, ANY DISTRIBUTION THEREOF WITHIN THE MEANING OF THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR IN ACCORDANCE WITH AN
EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT OF 1933, AS AMENDED.” 
  
 (h) It is understood and agreed that the legends set forth in paragraphs (f) and (g) above will be removed by delivery of substitute
certificates without such legend if such legend is not required for purposes of the Act or this letter agreement. Without limiting the foregoing, it is understood and agreed that such legends and the stop orders referred to above will be removed if:

  
 (i) one year shall have elapsed from the date
the undersigned acquired Amgen Common Stock received in the Merger and the provisions of Rule 145(d)(2) are then available to the undersigned; 
  
 (ii) two years shall have elapsed from the date the undersigned acquired Amgen Common Stock received in the Merger and the provisions of
Rule 145(d)(3) are then available to the undersigned; or 
  
 (iii) Amgen has received either an opinion of outside counsel, which opinion and outside counsel shall be reasonably satisfactory to Amgen, or a “no action” or interpretative letter obtained by the
undersigned from the staff of the Commission, to the effect that the restrictions imposed by Rule 145 no longer apply to the undersigned. 
  
 The obligations of the undersigned hereunder shall attach to and be binding upon any person or entity to whom legal or beneficial ownership of the
undersigned’s shares of Amgen Common Stock (and shares of Amgen Common Stock following the Merger) shall pass by operation of law or otherwise. 
  
  

 5 

 The execution and delivery to you of this letter agreement shall not be deemed an admission that the
undersigned is an “affiliate” of Tularik as described in the first paragraph of this letter or as a waiver of any rights the undersigned may have to object to any claim that the undersigned is such an affiliate on or after the date of this
letter. 
  
 Very truly yours, 
  
                                       
                                        
                                        
                          
 [Name] 
  
 Agreed to and
accepted 
  
 AMGEN INC. 
  
 By:                                     
                                        
                    
 Name: 
 Title: 
  

 6 

 Exhibit A to Affiliate Letter 
  
                      , 200   
  
 Amgen Inc. 
 One Amgen Center Drive 

Thousand Oaks, Ca 91320-1799 
  
 Ladies and Gentlemen: 
  
 On
                    , the undersigned sold
                     shares of common stock (“Common Stock”) of Amgen Inc., a Delaware corporation (the “Company”),
received by it in connection with the merger of Tularik Inc., a Delaware corporation, with Arrow Acquisition, LLC, a limited liability company wholly-owned by the Company. 
  
 The undersigned represents that the Common Stock has been sold in conformity with Rule 145 and the undersigned has complied
with its covenants in the affiliate letter between the Company and the undersigned dated                     , 2004 Based upon the most recent
report or statement filed by the Company with the Securities and Exchange Commission, the shares of Common Stock sold by the undersigned were within the prescribed limitations set forth in paragraph (e) of Rule 144 promulgated under the Securities
Act of 1933 (the “Act”). 
  
 The undersigned hereby
represents that the above-described shares of Common Stock were sold in “brokers’ transactions” within the meaning of Section 4(4) of the Act or in transactions directly with a “market maker” as the term is defined in
Section (3)(a)(38) of the Securities Exchange Act of 1934. The undersigned further represents that it has not solicited or arranged for the solicitation of orders to buy the above-described shares of Common Stock, and that the undersigned has not
made any payment in connection with the offer or sale of such shares to any person other than to the broker who executed the order in respect of such sale. 
  

	
	 Very truly yours,
  

	
	 
	

	 [Name]

  

 Annex A 
  

	
	 Stockholder                    

	 David V. Goeddel

	 A. Grant Heidrich, III

	 Edward W. Holmes

	 Edward R. McCracken

	 Steven L. McKnight

	 Craig A. P. D. Saxton

	 Andrew J. Perlman

	 Terry Rosen

	 William J. Rieflin

	 Jack M. Anthony

	 Michael D. LevyAmended and Restated Registration Rights Agreement dated January 10, 2003

 Exhibit 4.4 
  

  
 AMENDED AND RESTATED

 REGISTRATION RIGHTS AGREEMENT 
  
 DATED AS OF JANUARY 10, 2003 
  
 BY AND AMONG 
  
 CONCORDE CAREER COLLEGES, INC., 
  
 CAHILL WARNOCK STRATEGIC PARTNERS FUND, L.P. 
  
 AND 
  
 STRATEGIC
ASSOCIATES, L.P. 
  

 TABLE OF CONTENTS 
  

							
	 	  	Page

	 SECTION 1 Registration Rights
	  	1
	 	 	 1.1
	  	 Demand Registration Rights
	  	1
	 	 	 1.2
	  	 “Piggyback” Registration Rights
	  	2
	 	 	 1.3
	  	 Terms and Conditions of Registration or Qualification
	  	2
	 	 	 1.4
	  	 Exceptions to Registration Obligations
	  	6
	 	 	 1.5
	  	 Indemnity
	  	6
		
	 SECTION 2 Miscellaneous
	  	8
	 	 	 2.1
	  	 Additional Actions and Documents
	  	8
	 	 	 2.2
	  	 No Assignment
	  	9
	 	 	 2.3
	  	 Entire Agreement; Amendment
	  	9
	 	 	 2.4
	  	 Limitation on Benefits
	  	9
	 	 	 2.5
	  	 Binding Effect
	  	9
	 	 	 2.6
	  	 Governing Law
	  	9
	 	 	 2.7
	  	 Notices
	  	9
	 	 	 2.8
	  	 Headings
	  	10
	 	 	 2.9
	  	 Execution in Counterparts
	  	10

  

 i 

 AMENDED AND RESTATED 
 REGISTRATION RIGHTS AGREEMENT 
  
 THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (the “Agreement”) is made as of January 10, 2003, by and among CONCORDE CAREER COLLEGES, INC., a Delaware corporation (the “Company”), CAHILL, WARNOCK
STRATEGIC PARTNERS FUND, L.P., a limited partnership organized under the laws of the State of Delaware, and STRATEGIC ASSOCIATES, L.P., a limited partnership organized under the laws of the State of Delaware (collectively, the
“Purchasers”). 
  
 WHEREAS, the Company and the
Purchasers have entered into Debenture and Warrant Purchase Agreements, dated as of February 25, 1997 (the “Debenture Purchase Agreements”); 
  
 WHEREAS, pursuant to the Debenture Purchase Agreements, the Company and the Purchasers desire to enter into this Agreement to provide Purchasers with
certain stock registration rights and to address related matters; 
  
 WHEREAS, the Company and the Purchasers entered into a Conversion and Exchange Agreement, dated November 25, 2002, which provides, in part, that the Registration Rights Agreement by and among the Company and the Purchasers, dated February
25, 1997, be amended and restated to have the terms consistent with Article 6 of the Amended and Restated Stockholders’ Agreement by and among the Purchasers and the Company, dated November 25, 2002. 
  
 NOW THEREFORE, in consideration of the foregoing and of the mutual covenants
and agreements set forth herein, the parties agree as follows: 
  
 SECTION 1 
  
 Registration Rights 
  
 1.1 Demand Registration Rights. At any time and from time to time, the
Purchasers may request, in writing, registration for sale under the Securities Act of 1933, as amended (the “Act”), of all or at least 250,000 shares of the common stock, par value $0.10 per share, of the Company (the
“Shares”) then held by Purchasers or issuable to the Purchasers upon exercise of the Warrants issued by the Company to the Purchasers pursuant to the Debenture Purchase Agreements (the “Demand”). The Company shall promptly
thereafter (and in any event within 10 days after its receipt of such Demand) cause to be prepared a registration statement, file the registration statement within 60 days after the date of such Demand (45 days in the case of the Form S-3 )(using
Form S-3 or other “short form,” if available and advised by counsel) to the end that such Shares may be sold thereunder as soon as it becomes effective and the Company will use its reasonable best efforts to ensure that a distribution of
the Shares pursuant to the registration statement may continue for up to 9 months from the date of the effective date of the registration statement. Such registration shall hereinafter be called a “demand registration”. The demand
registration includes the right of the Purchasers to require 

 the Company to file a registration statement on Form S-3 (or if Form S-3 is unavailable to the Company, such other form
as is available) for an offering to be made on a continuous basis pursuant to a “shelf” registration statement under Rule 415 promulgated under the Securities Act. The Purchasers shall be entitled to request one demand registration. A
demand registration shall not count as such until a registration statement becomes effective and remains effective for 9 months or until all of the shares thereunder are sold; provided, that if, after it has become effective, the offering pursuant
to the registration statement is interfered with by any stop order, injunction or other order or requirement of the Commission or any other governmental authority, such registration shall be deemed not to have been affected unless such stop order,
injunction or other order shall subsequently have been vacated or otherwise removed. The Purchasers shall select the underwriters of any offering pursuant to a registration statement filed pursuant to this section 1.1, subject to the approval of the
Company, which approval shall not be unreasonably withheld. Any selected underwriter shall be a well recognized firm in good standing. 
  
 1.2 “Piggyback” Registration Rights. Subject to applicable stock exchange rules and securities regulations, at least 30 days prior to any
public offering of any of its Common Stock for the account of the Company or any other person (other than a registration statement on Form S-4 or S-8 (or any successor forms under the Securities Act) or other registrations relating solely to
employee benefit plans or any transaction governed by Rule 145 of the Securities Act), other than pursuant to the exercise of any Demand Registration pursuant to Section 1.1, the Company shall give written notice of such proposed filing and of the
proposed date thereof to Purchasers and if, on or before the twentieth (20th) day following the date on which such notice is given, the Company shall receive a written request from Purchasers requesting that the Company include among the securities
covered by such registration statement any Shares of Common Stock or Shares of Common Stock issued or issuable upon exercise of the Warrant for offering for sale in a manner and on terms set forth in such request, the Company shall include such
Shares in such registration statement, if filed, so as to permit such Shares to be sold or disposed of in the manner and on the terms of the offering thereof set forth in such request. Each such registration shall hereinafter be called a
“Piggyback Registration.” The Company shall select the underwriters of any offering pursuant to a registration statement filed pursuant to this Section 1.2, subject to the approval of the Purchasers, which approval shall not be
unreasonably withheld. 
  
 1.3 Terms and Conditions of
Registration or Qualification. In connection with any registration statement filed pursuant to Sections 1.1 or 1.2 hereof, the following provisions shall apply. 
  
 (a) The obligations of the Company to use its reasonable best efforts to cause the registration of Shares
under the Securities Act are subject to the limitation, condition and qualification that the Company shall be entitled to postpone for a reasonable period of time (but not exceeding 90 days in any one year period) the filing of any registration
statement otherwise required to be filed by it if the Company in good faith determines that such registration and offering would (i) interfere with any financing, acquisition, corporate reorganization or other material transaction or event involving
the Company or any of its subsidiaries or (ii) require premature disclosure thereof or of conditions, circumstances or events affecting the Company or the Company’s industry which are not yet fully developed or ripe for disclosure, in which
event the Company 
  

 2 

 shall promptly give the Purchasers requesting registration thereof written notice of such determination
and an approximation of the anticipated delay. If the Company shall so postpone the filing of a registration statement, the Purchasers shall have the right to withdraw the request for registration by giving written notice to the Company within 30
days after receipt of the notice of postponement and, in the event of such withdrawal, such request shall not be counted for purposes of the requests for registration to which Purchasers are entitled under this Agreement. 
  
 (b) If the managing underwriter advises that the inclusion
in such registration or qualification of some or all of the Shares sought to be registered exceeds the number (the “Saleable Number”) that can be sold in an orderly fashion or without adversely affecting the offering, then the
number of Shares offered shall be limited to the Saleable Number and shall be allocated as follows: 
  
 (i) If such registration is being effected pursuant to a Piggyback Registration under Section 1.2, (A) first, all the Shares the Company
(or in the exercise of demand registration rights, the selling stockholder(s) exercising such rights) proposes to register and (B) second, the difference between the Saleable Number and the number to be included pursuant to clause (A) above,
allocated to the Purchasers pro rata on the basis of the relative number of Shares offered for sale by each Purchaser; and 
  
 (ii) if such registration is being effected pursuant to a Demand Registration other than in connection with the first public offering
after the date of this Agreement of Common Stock of the Company, (A) first, the entire Saleable Number allocated first to the Purchasers on the basis of the relative number of Shares offered for sale by Purchasers, and then among all other selling
securityholders pro rata on the basis of the relative number of Shares offered for sale by each such securityholder and (B) second, the difference (if positive) between the Saleable Number and the number to be included pursuant to clause (A) above,
allocated to the Company. 
  
 (c) Purchasers will
promptly provide the Company with such information as the Company shall reasonably request in order to prepare such registration statement and, upon the Company’s request, each Purchaser shall provide such information in writing and signed by
such Purchaser and stated to be specifically for inclusion in the registration statement. In the event that the distribution of the Shares covered by the registration statement shall be effected by means of an underwriting, the right of any
Purchaser to include its Shares in such registration shall be conditioned on such Purchaser’s execution and delivery of a customary underwriting agreement with respect thereto; provided, however, that except with respect to
information concerning such holder and such Purchaser’s intended manner of distribution of the Shares, no Purchaser shall be required (as a Purchaser exercising registration rights) to make any representations or warranties in such agreement as
a condition to the inclusion of its Shares in such registration. 
  

 3 

 (d) The Company shall bear all expenses in connection with the preparation of any
registration statement filed pursuant to Section 1.1, including the fees and disbursements of one counsel for Purchasers. 
  
 (e) The Company shall bear all expenses in connection with the preparation of any registration statement filed pursuant to Section 1.2,
excluding (i) the fees and disbursements of counsel for Purchasers, and (ii) the underwriting fees, discounts or commissions with respect to Shares of Purchasers, which shall be borne by Purchasers. 
  
 (f) Following the effective date of such registration
statement, the Company shall, upon the request of Purchasers, forthwith supply such number of prospectuses (including preliminary prospectuses and amendments and supplements thereto) meeting the requirements of the Securities Act or such other
securities laws where the registration statement or prospectus has been filed and such other documents as are referred to in the registration statement as shall be requested by Purchasers to permit such Purchasers to make a public distribution of
their Shares, provided that Purchasers furnish the Company with such appropriate information relating to such Purchasers’ intentions in connection therewith as the Company shall reasonably request in writing. 
  
 (g) The Company shall prepare and file such amendments and
supplements to such registration statement as may be necessary to keep such registration statement effective and to comply with the provisions of the Securities Act or such other securities laws where the registration statement has been filed with
respect to the offer and sale or other disposition of the shares covered by such registration statement during the period required for distribution of the Shares, which period shall not be in excess of nine (9) months from the effective date of such
registration statement. 
  
 (h) The Company shall
use its reasonable best efforts to register or qualify the Shares of Purchasers covered by any such registration statement under such securities or Blue Sky laws in such jurisdictions as Purchasers may reasonably request; provided,
however, that the Company shall not be required to execute a general consent to service of process or to qualify to do business as a foreign corporation in any jurisdiction where it is not so qualified in order to comply with such request.

  
 (i) In connection with any registration
pursuant to Sections 1.1 and 1.2, the Company will as expeditiously as possible: 
  
 (A) cause the Shares covered by such registration statement to be registered with or approved by such other governmental agencies or
authorities as may be necessary by virtue of the business and operations of the Company to enable Purchasers to consummate the disposition of such Shares; 
  
 (B) notify each Purchaser at any time of the happening of any event as a result of which the prospectus included in such registration
statement contains an untrue statement of a material fact or 
  

 4 

 omits to state any material fact required to be stated therein or necessary to make the statements
therein not misleading, and the Company will prepare a supplement or amendment to such prospectus so that, as thereafter delivered to the Purchasers of such Shares, such prospectus will not contain an untrue statement of a material fact or omit to
state any material fact required to be stated therein or necessary to make the statements therein not misleading; 
  
 (C) cause all Shares covered by the registration statement to be listed on each securities exchange on which similar securities issued by
the Company are then listed and, unless the same already exists, provide a transfer agent, registrar and CUSIP number for all such Shares not later than the effective date of the registration statement; 
  
 (D) enter into such customary agreements (including an
underwriting agreement in customary form) and take all such other actions as the Purchasers or the underwriters retained by such Purchasers, if any, reasonably request in order to expedite or facilitate the disposition of such Shares; 
  
 (E) make available for inspection by any Purchaser, any
underwriter participating in any disposition pursuant to such registration statement, and any attorney, accountant or other agent retained by any such seller or underwriter (collectively, the “Inspectors”), all financial and other
records, pertinent corporate documents and properties of the Company as shall be necessary to enable them to exercise their due diligence responsibility, and cause the Company’s officers, directors and employees to supply all information
reasonably requested by any such Inspector in connection with such registration statement, provided that such Inspectors shall have first executed and delivered to the Company a confidentiality agreement in customary form protecting the
confidentiality of such information; 
  
 (F)
obtain “cold comfort” letters and updates thereof from the Company’s independent public accountants and an opinion from the Company’s counsel in customary form and covering such matters of the type customarily covered by
“cold comfort” letters and opinion of counsel, respectively, as Purchasers may reasonably request; and 
  
 (G) otherwise comply with all applicable rules and regulations of the Commission, and make available to the Purchasers, as soon as
reasonably practicable, an earnings statement covering a period of 12 months, beginning within three months after the effective date of the registration statement, which earnings statement shall satisfy the provisions of Section 11(a) of the
Securities Act and Rule 158 thereunder. 
  

 5 

 (j) Each Purchaser agrees that, upon receipt of any notice from the Company of the
happening of any event of the kind described in Section 1.3(i)(B), such holder will forthwith discontinue disposition of its Shares pursuant to the registration statement covering such Shares until such Purchaser’s receipt of the copies of the
supplemented or amended prospectus contemplated by such Section 1.3(i)(B) and, if so directed by the Company, such Purchaser will deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then in such
Purchaser’s possession, of the prospectus covering such Shares current at the time of receipt of such notice. 
  
 1.4 Exceptions to Registration Obligations. The Company shall not be required to effect any registration of Shares pursuant to Section 1.1 or
Section 1.2 hereof if it shall deliver to the Purchaser requesting such registration an opinion of counsel in a form reasonably satisfactory to such Purchaser to the effect that all such Shares held by such Purchaser may be sold in the public market
pursuant to Rule 144(k) and without registration under the Securities Act and any applicable state securities laws. 
  
 1.5 Indemnity. 
  
 (a) In the event of the registration or qualification of any Shares of the Purchasers under the Securities Act or any other applicable
securities laws pursuant to the provisions of Sections 1.1 and 1.2, the Company agrees to indemnify and hold harmless each Purchaser thereby offering such Shares for sale (a “Seller”), underwriter, broker or dealer, if any, of such
Shares, and each other person, if any, who controls any such Seller, underwriter, broker or dealer within the meaning of the Securities Act or any other applicable securities laws, from and against any and all losses, claims, damages or liabilities
(or actions in respect thereof), joint or several, to which such Seller, underwriter, broker or dealer or controlling person may become subject under the Securities Act or any other applicable securities laws or otherwise, insofar as such losses,
claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in any registration statement under which such Shares were registered or
qualified under the Securities Act or any other applicable securities laws, any preliminary prospectus or final prospectus relating to such Shares, or any amendment or supplement thereto, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, or any violation by the Company of any rule or regulation under the Securities Act or any other applicable securities
laws applicable to the Company or relating to any action or inaction required by the Company in connection with any such registration or qualification and will reimburse each such Seller, underwriter, broker or dealer and each such controlling
person for any legal or other expenses reasonably incurred by such Seller, underwriter, broker or dealer or controlling person in connection with investigating or defending any such loss, claim, damage, liability or action; provided,
however, that the Company will not be liable in any such case to the extent that any such loss, claim, damage or liability arises out of or is based upon an untrue statement or omission made in such registration statement, such preliminary
prospectus, such final prospectus or such amendment or supplement thereto or violation in reliance upon and in conformity with written information furnished to the Company by such Seller, 
  

 6 

 underwriter, broker, dealer or controlling person specifically and expressly for use in the preparation
thereof; and provided, further, that the Company shall not be liable to any person who participates as an underwriter in the offering or sale of Shares or any other person, if any, who controls such underwriter within the meaning of
the Securities Act, in any such case to the extent that any such loss, claim, damage, liability (or action or proceeding in respect thereof) or expense arises out of such person’s failure to send or give a copy of the final prospectus, as the
same may be then supplemented or amended, to the person asserting an untrue statement or alleged untrue statement or omission or alleged omission at or prior to the written confirmation of the sale of Shares to such person if such statement or
omission was corrected in such final prospectus so long as such final prospectus, and any amendments or supplements thereto, have been furnished to such underwriter. 
  
 (b) In the event of the registration or qualification of any Shares of Seller under the Securities Act or
any other applicable securities laws for sale pursuant to the provisions of Sections 1.1 and 1.2, each Seller, each underwriter, broker and dealer, if any, of such Shares, and each other person, if any, who controls any such Seller, underwriter,
broker or dealer within the meaning of the Securities Act, agrees severally, and not jointly to indemnify and hold harmless the Company, each person who controls the Company within the meaning of the Securities Act, and each officer and director of
the Company from and against any and all losses, claims, damages or liabilities (or actions in respect thereof), joint or several, to which the Company, such controlling person or any such officer or director may become subject under the Securities
Act or any other applicable securities laws or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement of any material fact contained in any registration
statement under which such Shares were registered or qualified under the Securities Act or any other applicable securities laws, any preliminary prospectus or final prospectus relating to such Shares, or any amendment or supplement thereto, or arise
out of or are based upon an untrue statement or the omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading or any violation by the Company of any rule or regulation under
the Securities Act or any other applicable securities laws applicable to the Company or relating to any action or inaction required by the Company in connection with any such registration or qualification, and will reimburse the Company, such
controlling person and each such officer or director for any legal or any other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however,
that no Seller will be liable under this Section 1.4(b) for any amount in excess of the net proceeds paid to such Seller of Shares sold by it unless such liability arises from such written information furnished to the Company with knowledge of its
misleading nature or an intent to defraud. 
  
 (c) Promptly after receipt by a person entitled to indemnification under this Section 1.4 (an “indemnified party”) of notice of the commencement of any action or claim relating to any registration statement filed under
Section 1.1 or 1.2 or as to which indemnity may be sought hereunder, such indemnified party will, if a claim for indemnification hereunder in respect thereof is to be made against any other party hereto 
  

 7 

 (an “indemnifying party”), give written notice to such indemnifying party of the
commencement of such action or claim, but the omission to so notify the indemnifying party will not relieve the indemnifying party from any liability that it may have to any indemnified party otherwise than pursuant to the provisions of this Section
1.4 and shall also not relieve the indemnifying party of its obligations under this Section 1.4 except to the extent that the indemnifying party is actually prejudiced thereby. In case any such action is brought against an indemnified party, and it
notifies an indemnifying party of the commencement thereof, the indemnifying party will be entitled (at its own expense) to participate in and, to the extent that it may wish, jointly with any other indemnifying party similarly notified, to assume
the defense, with counsel reasonably satisfactory to such indemnified party, of such action and/or to settle such action and, after notice from the indemnifying party to such indemnified party of its election so to assume the defense thereof, the
indemnifying party will not be liable to such indemnified party for any legal or other expenses subsequently incurred by such indemnified party in connection with the defense thereof, other than the reasonable cost of investigation; provided,
however, that no indemnifying party shall enter into any settlement agreement without the prior written consent of the indemnified party unless such indemnified party is fully released and discharged from any such liability. Notwithstanding
the foregoing, the indemnified party shall have the right to employ its own counsel in any such case, but the fees and expenses of such counsel shall be at the expense of such indemnified party unless (i) the employment of such counsel shall have
been authorized in writing by the indemnifying party in connection with the defense of such suit, action, claim or proceeding, (ii) the indemnifying party shall not have employed counsel (reasonably satisfactory to the indemnified party) to take
charge of the defense of such action, suit, claim or proceeding, or (iii) such indemnified party shall have reasonably concluded, based upon the advice of counsel, that there may be defenses available to it that are different from or additional to
those available to the indemnifying party which, if the indemnifying party and the indemnified party were to be represented by the same counsel, could result in a conflict of interest for such counsel or materially prejudice the prosecution of the
defenses available to such indemnified party. If any of the events specified in clauses (i), (ii) or (iii) of the preceding sentence shall have occurred or shall otherwise be applicable, then the fees and expenses of one counsel or firm of counsel
selected by a majority in interest of the indemnified parties (and reasonably acceptable to the indemnifying party) shall be borne by the indemnifying party. If, in any such case, the indemnified party employs separate counsel, the indemnifying
party shall not have the right to direct the defense of such action, suit, claim or proceeding on behalf of the indemnified party and the indemnified party shall assume such defense and/or settle such action; provided, however, that an
indemnifying party shall not be liable for the settlement of any action, suit, claim or proceeding effected without its prior written consent, which consent shall not be unreasonably withheld. 
  
 SECTION 2 
  
 Miscellaneous 
  
 2.1 Additional Actions and Documents. Each of the parties hereto hereby agrees to use its good faith best efforts to bring about the consummation
of this Agreement, and 
  

 8 

 to take or cause to be taken such further actions, to execute, deliver and file or cause to be executed, delivered and
filed such further documents and instruments, and to obtain such consents, as may be necessary or as may be reasonably requested in order to fully effectuate the purposes, terms and conditions of this Agreement. 
  
 2.2 No Assignment. The right of Purchasers herein are personal and may
not be assigned or transferred to any third party without the Company’s prior express written consent. 
  
 2.3 Entire Agreement; Amendment. This Agreement, including the other writings referred to herein or delivered pursuant hereto, constitutes the
entire agreement among the parties hereto with respect to the transactions contemplated herein, and it supersedes all prior oral or written agreements, commitments or understandings with respect to the matters provided for herein. No amendment,
modification or discharge of this Agreement shall be valid or binding unless set forth in writing and duly executed by the party against whom enforcement of the amendment, modification, or discharge is sought. 
  
 2.4 Limitation on Benefits. It is the explicit intention of the
parties hereto that no person or entity other than the parties hereto (and their respective successors and assigns) is or shall be entitled to bring any action to enforce any provision of this Agreement against any of the parties hereto, and the
covenants, undertakings and agreements set forth in this Agreement shall be solely for the benefit of, and shall be enforceable only by, the parties hereto or their respective successors and assigns. 
  
 2.5 Binding Effect. This Agreement shall be binding upon and shall
inure to the benefit of the parties hereto and their respective successors and assigns. 
  
 2.6 Governing Law. This Agreement, the rights and obligations of the parties hereto, and any claims or disputes relating thereto, shall be governed by and construed in accordance with the laws of Delaware
(excluding the choice of law rules thereof). 
  
 2.7
Notices. All notices, demands, requests, or other communications which may be or are required to be given, served, or sent by any party to any other party pursuant to this Agreement shall be in writing and shall be mailed by first-class,
registered or certified mail, return receipt requested, postage prepaid, or transmitted by hand delivery (including delivery by courier), or facsimile transmission, addressed as follows: 
  

	 	(a)	If to the Company: 

  

	 	    	Concorde Career Colleges, Inc. 

	 	    	Mission Corporate Centre 

	 	    	5800 Fox Ridge Drive, Suite 500 

	 	    	Mission, Kansas 66202 

	 	    	Attn: Jack L. Brozman 

  

 9 

	 	    	with a copy to: 

  

	 	    	Bryan Cave, L.L.P. 

	 	    	3500 One Kansas City Place 

	 	    	1200 Main Street 

	 	    	Kansas City, Missouri 64105 

	 	    	Attn: Thomas W. Van Dyke, Esquire 

  

	 	(b)	if to the Purchasers: 

  

	 	    	c/o Cahill, Warnock Strategic Partners, L.P. 

	 	    	One South Street, Suite 2150 

	 	    	Baltimore, Maryland 21202 

	 	    	Attn: David Warnock 

  

	 	    	with a copy to: 

  

	 	    	Wilmer, Cutler & Pickering 

	 	    	1600 Tysons Blvd. 

	 	    	McLean, Virginia 22102 

	 	    	Attn: Gregory J. Ewald, Esquire 

  
 Each party may designate by notice in writing a new address to which any notice, demand, request or communication may thereafter be so given, served or sent. Each notice,
demand, request, or communication which shall be mailed, delivered or transmitted in the manner described above shall be deemed sufficiently given, served, sent and received for all purposes at such time as it is delivered to the addressee (with the
return receipt, the delivery receipt, the affidavit of messenger or facsimile transmission confirmation being deemed conclusive (but not exclusive) evidence of such delivery) or at such time as delivery is refused by the addressee upon presentation.

  
 2.8 Headings. Article and Section headings contained in
this Agreement are inserted for convenience of reference only, shall not be deemed to be a part of this Agreement for any purpose, and shall not in any way define or affect the meaning, construction or scope of any of the provisions hereof.

  
 2.9 Execution in Counterparts. To facilitate execution,
this Agreement may be executed in as many counterparts as may be required; and it shall not be necessary that the signatures of each party appear on each counterpart; but it shall be sufficient that the signature of each party appear on one or more
of the counterparts. All counterparts shall collectively constitute a single agreement. It shall not be necessary in making proof of this Agreement to produce or account for more than a number of counterparts containing the respective signatures of
all of the parties hereto. 
  
 [Remainder of Page Left Blank
Intentionally — Signature Page Follows] 
  

 10 

 AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 
  
 IN WITNESS WHEREOF, each of the parties hereto has caused this Agreement to
be duly executed on its behalf as of the date first above written. 
  

					
	 CONCORDE CAREER COLLEGES, INC.

		
	 By:
	 	     /s/ Jack L. Brozman

	 	 	     Name:
	 	 Jack L. Brozman

	 	 	     Title:
	 	 President and Chief Executive Officer

	
	 CAHILL, WARNOCK STRATEGIC PARTNERS FUND, L.P.

		
	 By:
	 	 CAHILL, WARNOCK STRATEGIC PARTNERS, L.P., its General Partner

		
	 By:
	 	     /s/ David L. Warnock

	 	 	     Name:
	 	 David L. Warnock

	 	 	     Title:
	 	 a General Partner

	
	 STRATEGIC ASSOCIATES, L.P.

		
	 By:
	 	 CAHILL, WARNOCK STRATEGIC PARTNERS, L.P., its General Partner

		
	 By:
	 	     /s/ David L. Warnock

	 	 	     Name:
	 	 David L. Warnock

	 	 	     Title:
	 	 a General Partner

  

 11

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