Document:

Collaboration Agreement dated March 30, 2012

 EXHIBIT 10.55 

 

	Note:	Redacted portions have been marked with [*]. The redacted portions are subject to a request for confidential treatment that has been filed with the Securities and
Exchange Commission. 

  
  
 COLLABORATION AGREEMENT 
 BY
AND BETWEEN 
 AMGEN INC. 

AND 
 ASTRAZENECA COLLABORATION VENTURES, LLC 

 TABLE OF CONTENTS 

 

							
	 1
	 	DEFINITIONS	  	 	1	  
	 2
	 	SCOPE AND GOVERNANCE	  	 	17	  
		 	 2.1 Purpose of the Collaboration
	  	 	17	  
		 	 2.2 Ex-Territory Activities
	  	 	17	  
		 	 2.3 Committees and Teams
	  	 	18	  
		 	 2.4 Joint Product Teams.
	  	 	19	  
		 	 2.5 Joint Steering Committee.
	  	 	20	  
		 	 2.6 Collaboration Review Committee
	  	 	21	  
		 	 2.7 Reporting
	  	 	22	  
		 	 2.8 No Authority to Amend or Modify
	  	 	22	  
		 	 2.9 Alliance Managers
	  	 	22	  
		 	 2.10 Patent Coordinators
	  	 	22	  
	 3
	 	DEVELOPMENT AND REGULATORY	  	 	22	  
		 	 3.1 Development Matters
	  	 	22	  
		 	 3.2 Regulatory Matters
	  	 	24	  
		 	 3.3 Brand Security and Anti-Counterfeiting
	  	 	25	  
		 	 3.4 Product Complaints, Recalls and Returns
	  	 	26	  
		 	 3.5 Clinical Trial Register
	  	 	26	  
		 	 3.6 Sharing of Data and Know-How
	  	 	26	  
	 4
	 	MANUFACTURING	  	 	26	  
		 	 4.1 Allocation of Manufacturing Responsibility
	  	 	26	  
		 	 4.2 Manufacturing Lead
	  	 	27	  
		 	 4.3 [*] Updates
	  	 	27	  
		 	 4.4 Distribution
	  	 	27	  
		 	 4.5 Quality and Safety Agreements
	  	 	28	  
		 	 4.6 Shortage; Allocation
	  	 	28	  
	 5
	 	COMMERCIALIZATION	  	 	28	  
		 	 5.1 Allocation of Commercial Responsibility
	  	 	28	  
		 	 5.2 Commercial Lead
	  	 	29	  
		 	 5.3 Initial Plans; [*] Updates
	  	 	29	  
		 	 5.4 All Sales by Distribution Party
	  	 	29	  
		 	 5.5 Training
	  	 	29	  
		 	 5.6 Information Concerning Products
	  	 	29	  
		 	 5.7 Promotional Materials
	  	 	29	  
		 	 5.8 Detailing Reports and Audit Rights
	  	 	30	  
		 	 5.9 Competing Products
	  	 	31	  
		 	 5.10 Sales Force [*]
	  	 	31	  
	 6
	 	PERFORMANCE STANDARDS	  	 	32	  
		 	 6.1 Collaborative Activities
	  	 	32	  
		 	 6.2 Diligence and Performance Standards
	  	 	32	  
		 	 6.3 Violation of Laws
	  	 	32	  
		 	 6.4 Use of Affiliates and Third Party Contractors
	  	 	32	  
		 	 6.5 Management of Personnel
	  	 	33	  
	 7
	 	UP-FRONT PAYMENT AND PROFIT/EXPENSE SHARING	  	 	33	  

  
 i 

							
		 	 7.1 Up-front Payment
	  	 	33	  
		 	 7.2 Profit/Expense Sharing
	  	 	33	  
		 	 7.3 Example
	  	 	37	  
		 	 7.4 Calculation of Net Revenues
	  	 	37	  
		 	 7.5 Excluded Losses
	  	 	38	  
		 	 7.6 Manufacturing Costs Calculation and True-Up
	  	 	39	  
		 	 7.7 Budget Deadlocks
	  	 	39	  
		 	 7.8 Program Recommitment
	  	 	39	  
	 8
	 	PAYMENTS	  	 	42	  
		 	 8.1 Appropriate Measure of Value
	  	 	42	  
		 	 8.2 No Other Compensation
	  	 	42	  
		 	 8.3 Currency
	  	 	42	  
		 	 8.4 Audits
	  	 	43	  
		 	 8.5 Blocked Currency
	  	 	43	  
		 	 8.6 Taxes
	  	 	43	  
		 	 8.7 Late Payment
	  	 	45	  
		 	 8.8 Change in Accounting Periods
	  	 	45	  
	 9
	 	DISTRACTING PRODUCTS	  	 	45	  
		 	 9.1 Distracting Program
	  	 	45	  
		 	 9.2 Post-Effective Date Affiliates
	  	 	46	  
		 	 9.3 Termination, Divestiture or Inclusion
	  	 	46	  
		 	 9.4 Pre-Clinical Research and Development Programs
	  	 	48	  
		 	 9.5 Reasonable Restrictions
	  	 	48	  
	 10
	 	INTELLECTUAL PROPERTY	  	 	49	  
		 	 10.1 Invention Ownership
	  	 	49	  
		 	 10.2 Copyright Ownership; Certain Confidential Information
	  	 	49	  
		 	 10.3 Joint Ownership
	  	 	49	  
		 	 10.4 License Grant by Amgen
	  	 	50	  
		 	 10.5 License Grant by Partner
	  	 	50	  
		 	 10.6 Prosecution and Maintenance
	  	 	50	  
		 	 10.7 Defense and Settlement of Third Party Claims of Infringement
	  	 	52	  
		 	 10.8 Enforcement
	  	 	52	  
		 	 10.9 Patent Term Extensions
	  	 	53	  
		 	 10.10 Trademarks.
	  	 	53	  
	 11
	 	CONFIDENTIALITY, PUBLICATIONS AND PRESS RELEASES	  	 	54	  
		 	 11.1 Confidentiality; Exceptions
	  	 	54	  
		 	 11.2 Authorized Disclosure
	  	 	55	  
		 	 11.3 Confidential Treatment of Terms and Conditions
	  	 	57	  
		 	 11.4 Press Releases
	  	 	57	  
		 	 11.5 Prior Agreement
	  	 	57	  
		 	 11.6 Publications and Program Information
	  	 	57	  
	 12
	 	REPRESENTATIONS AND WARRANTIES	  	 	58	  
		 	 12.1 Mutual Representations and Warranties
	  	 	58	  
		 	 12.2 Amgen Representations and Warranties
	  	 	59	  
		 	 12.3 Mutual Covenants
	  	 	60	  
		 	 12.4 Amgen Covenant
	  	 	61	  

  
 ii 

							
		 	 12.5 AstraZeneca Covenant
	  	 	61	  
		 	 12.6 Disclaimer of Warranties
	  	 	61	  
		 	 12.7 Limitation of Liability
	  	 	62	  
	 13
	 	INDEMNIFICATION AND INSURANCE	  	 	62	  
		 	 13.1 Indemnity by Partner
	  	 	62	  
		 	 13.2 Indemnity by Amgen
	  	 	62	  
		 	 13.3 Claim for Indemnification
	  	 	62	  
		 	 13.4 Defense of Third Party Claims
	  	 	63	  
		 	 13.5 Insurance
	  	 	63	  
	 14
	 	TERM AND TERMINATION	  	 	63	  
		 	 14.1 Term
	  	 	63	  
		 	 14.2 Termination for Convenience
	  	 	64	  
		 	 14.3 Termination for Breach
	  	 	64	  
		 	 14.4 Termination for Insolvency
	  	 	64	  
		 	 14.5 Termination for Challenge
	  	 	65	  
		 	 14.6 Effects of Termination
	  	 	65	  
	 15
	 	MISCELLANEOUS	  	 	72	  
		 	 15.1 Affiliates
	  	 	72	  
		 	 15.2 Assignment
	  	 	72	  
		 	 15.3 Choice of Law; Jurisdiction
	  	 	72	  
		 	 15.4 Construction
	  	 	73	  
		 	 15.5 Counterparts
	  	 	73	  
		 	 15.6 Entire Agreement
	  	 	73	  
		 	 15.7 Force Majeure
	  	 	73	  
		 	 15.8 Further Assurances
	  	 	74	  
		 	 15.9 Headings
	  	 	74	  
		 	 15.10 No Set-Off
	  	 	74	  
		 	 15.11 Notices
	  	 	74	  
		 	 15.12 Relationship of the Parties
	  	 	74	  
		 	 15.13 Severability
	  	 	75	  
		 	 15.14 Third Party Beneficiaries
	  	 	75	  
		 	 15.15 Waivers and Modifications
	  	 	75	  
		 	 15.16 [*]
	  	 	75	  

  
 iii

	
	SCHEDULES
	
	AMG827 TERRITORY
	AMGEN DISTRIBUTION COUNTRIES
	COMMERCIAL ALLOCATION
	COMPLETED CLINICAL TRIALS
	[*] DESIGNATED ENDPOINTS [*]
	DEVELOPMENT/COMMERCIAL LEAD
	DISTRACTING PRODUCT
	INVOICE
	PRESS RELEASE
	PRODUCTS
	PROFIT (LOSS) EXAMPLE
	QUALITY AGREEMENT
	STAGE 1 CLINICAL TRIAL

  
 iv 

 COLLABORATION AGREEMENT 

This Collaboration Agreement (this “Agreement”) is entered into as of the 30th day of March, 2012 (the “Effective Date”) by and
between Amgen Inc., a Delaware corporation with a place of business at One Amgen Center Drive, Thousand Oaks, California 91320 (“Amgen”), and AstraZeneca Collaboration Ventures, LLC, a Delaware limited liability company with a place
of business at 1800 Concord Pike, Wilmington, Delaware 19850 (“Partner”). Amgen and Partner are sometimes referred to herein individually as a “Party” and collectively as the “Parties”. AstraZeneca
Pharmaceuticals LP, the parent corporation of Partner (“AstraZeneca”), [*] is a party to this Agreement [*]. 

RECITALS 
 WHEREAS, Amgen is a global biopharmaceutical company that researches, develops, manufactures and commercializes novel therapeutics to treat grievous illness; 

WHEREAS, Amgen has developed certain proprietary Products (as defined below) for the treatment of certain diseases and
conditions; and 
 WHEREAS, Amgen and Partner desire to collaborate, and share certain expenses and revenues,
with respect to the development, manufacture and commercialization of the Products as set forth in more detail herein. 
 NOW, THEREFORE, in consideration of the premises and the mutual promises set forth herein, and intending to be legally bound, the Parties agree as follows: 

1.    DEFINITIONS 
  

	1.1.	 “Access and Pricing Plan” means the country specific plan for a Product approved by the JSC that sets forth the proposed price,
target population and reimbursement target. 

  

	1.2.	 “Affiliate” means, with respect to a Party, any Person which controls, is controlled by or is under common control with such Party.
For purposes of this definition only, “control” means the actual power, either directly or indirectly through one or more intermediaries, to direct or cause the direction of the management and policies of such Person, whether by the
ownership of more than fifty percent (50%) of the securities entitled to be voted generally or in the election of directors of such Person, or by contract or otherwise. For clarity, Kirin-Amgen, Inc. shall not be considered an Affiliate of
Amgen. Notwithstanding the foregoing, for the purposes of Article 9 (Distracting Products) and Section 1.51 (“Distracting Transaction”) only, [*]. 

 

	1.3.	 “Agreement” has the meaning set forth in the Preamble. 

 

	1.4.	 “Alliance Manager” has the meaning set forth in Section 2.9 (Alliance Managers). 

 

	1.5.	 “AMG157 Data Package” has the meaning set forth in Section 14.2 (Termination for Convenience). 

 

	1.6.	 “AMG157 Termination Event” has the meaning set forth in Section 14.2 (Termination for Convenience).

  

	1.7.	 “AMG827 Territory” means Australia, Canada, Mexico, New Zealand, the United States (its territories and possessions), all European
countries, including those listed in Column 1 of the AMG827 Territory Schedule attached hereto, all Central and South 

  
 1 

	 	 
American countries, including those listed in Column 2 of AMG827 Territory Schedule attached hereto, and those certain African and Middle East countries listed in Column 3 of AMG827 Territory
Schedule attached hereto. 

  

	1.8.	 “Amgen” has the meaning set forth in the Preamble. 

 

	1.9.	 “Amgen Costs” has the meaning set forth in Section 7.2.2 (Amgen Costs). 

 

	1.10.	 “Amgen Distribution Countries” means those countries listed on the Amgen Distribution Countries Schedule.

  

	1.11.	 “Amgen Housemarks” means (i) the corporate logo of Amgen, (ii) the trademark “Amgen”, (iii) any other
trademark, trade name or service mark (whether registered or unregistered) containing the word “Amgen”, and (iv) any other trademark or service mark associated with goods or services of Amgen or its Affiliates, but excluding the
Product Trademarks and trademarks, trade names or service marks associated with goods or services outside the scope of this Agreement; and all intellectual property rights residing in any of the foregoing. 

 

	1.12.	 “Amgen Indemnitees” has the meaning set forth in Section 13.1 (Indemnity by Partner). 

 

	1.13.	 “Amgen Intellectual Property” means any Know-How, Patent, electronic media registrations (including domain names, usernames,
websites, blogs and the like), or Copyright controlled by Amgen or its Affiliates that (i) as of the Effective Date is being used in connection with the research and development of any of the Products, or (ii) is used (but is not generated
or conceived) during the Term by either Party or its Affiliates in the performance of this Agreement. Amgen Intellectual Property specifically excludes Program Intellectual Property. 

 

	1.14.	 “Amgen Sales Force Costs” means the allocable share of Amgen’s or its Affiliates’ sales force costs for sales
representatives that Detail Products in the Collaboration Scope in accordance with this Agreement, calculated in accordance with Section 7.2.11 (Calculation of Sales Force Costs). 

 

	1.15.	 “Anti-Corruption Laws” means the US Foreign Corrupt Practices Act, as amended, the UK Bribery Act 2010, as amended, and any other
applicable anti-corruption laws and laws for the prevention of fraud, racketeering, money laundering or terrorism. 

  

	1.16.	 “Applicable Laws” means, individually and collectively, any federal, state, local, national and supra-national laws, treaties,
statutes, ordinances, rules and regulations, including any rules, regulations, guidance, guidelines or requirements having the binding effect of law of national securities exchanges, automated quotation systems or securities listing organizations,
Governmental Authorities, courts, tribunals, agencies other than Governmental Authorities, legislative bodies and commissions that are in effect from time to time during the Term and applicable to a particular activity hereunder.

  

	1.17.	 “Assisting Party” has the meaning set forth in Section 13.4 (Defense of Third Party Claims). 

 

	1.18.	 “AstraZeneca” has the meaning set forth in the Preamble. 

 

	1.19.	 “Audited Party” has the meaning set forth in Section 8.4 (Audits). 

  
 2 

	1.20.	 “Auditing Party” has the meaning set forth in Section 8.4 (Audits). 

 

	1.21.	 “Brand Plan” means the global, cross-functional commercialization plan for a Product approved by the JSC, including any applicable
Global Payer Plan and country specific Access and Pricing Plan. 

  

	1.22.	 “Bundle” means any Product sold together with another pharmaceutical compound for a single price, including combination products or
more than one product sold together. 

  

	1.23.	 “cGMP” has the meaning set forth in the applicable Quality Agreement. 

 

	1.24.	 “Collaboration Review Committee” or “CRC” means the review committee established pursuant to Article 2 (Scope and
Governance). 

  

	1.25.	 “Collaboration Profit (Loss)” has the meaning set forth in Section 7.2.8 (Calculation of Profit (or Loss)).

  

	1.26.	 “Collaboration Scope” means, with respect to a particular Product, any and all uses of such Product in the applicable Collaboration
Territory. 

  

	1.27.	 “Collaboration Territory” means the world, except for the Excluded Territory for AMG557 and AMG827. 

	1.28.	 “Commercialization Budget” has the meaning set forth in Section 2.4.1.3. An initial Commercialization Budget for each Product
will be approved by the JSC not later than three (3) months after initiation of the first Phase 3 Trial for such Product. 

  

	1.29.	 “Commercial Lead” has the meaning set forth in Section 5.2 (Commercial Lead). 

 

	1.30.	 “Commercially Reasonable Efforts” means, with respect to activities of a Party related to a Product under this Agreement, the
efforts and resources typically used by that Party in the conduct of such activities with respect to products of comparable market potential, taking into account all relevant factors including, as applicable, stage of development, efficacy and
safety relative to competitive products in the marketplace, actual or anticipated Governmental Authority approved labeling, the nature and extent of market exclusivity (including patent coverage and regulatory exclusivity), and cost and likelihood
of obtaining Regulatory Approval. For purposes of clarity, Commercially Reasonable Efforts will be determined on a country-by-country basis within the Collaboration Territory, and it is anticipated that the level of effort may be different for
different countries and may change over time, reflecting changes in the status of a Product and the country(ies) involved. 

  

	1.31.	 “Competing Product” has the meaning set forth in Section 5.9 (Competing Products). 

 

	1.32.	 “Confidential Information” has the meaning set forth in Section 11.1 (Confidentiality; Exceptions).

  

	1.33.	 “Continued Development Meeting” means on a Product-by-Product basis, a meeting of the JSC to be held promptly following the
completion of the Stage 1 Clinical Trial(s) for such Product, in which the JSC will discuss plans for the next phase of development of each such Product. 

 

	1.34.	 “Contract Interest Rate” means [*], plus the thirty (30) day U.S. Dollar LIBOR rate effective for the date that payment
was due, as published by The Wall Street Journal, Eastern U.S. Edition, on the date such payment was due (or, if unavailable on such 

  
 3 

	 	 
date, the first date thereafter on which such rate is available), or, if lower, the maximum rate permitted by Applicable Law. 

 

	1.35.	 “Copyright” means all right, title, and interest in and to all copyrightable works and any copyright registration or corresponding
legal right. 

  

	1.36.	 “Costs” means both internal and external costs and expenses (including the cost of allocated FTEs at the FTE Rate).

  

	1.37.	 “Country Plans” has the meaning set forth in Section 5.1 (Allocation of Commercial Responsibility).

  

	1.38.	 “Critical Matters” means (A) all decisions made by the CRC, JSC and JPTs that, in the reasonable opinion of either Party, are
likely to have any of the following impacts: (i) [*] under a Development Plan or Brand Plan; (ii) a change to a Development Plan or Brand Plan that results in the lesser of (a) an increase of [*] or more (provided, that such
amount is at least [*]) and (b) [*] or more, in each case, to the then-current budgeted amount of Development Costs and/or General Costs for any specific calendar year under the applicable Development Budget, Operations Budget or
Commercialization Budget or the amounts estimated under Sections 7.2.1 (Partner Costs) and 7.2.2 (Amgen Costs); (iii) a change to a Development Plan or Brand Plan that results in a decrease of [*] (provided, that such amount is at least
[*]) or more to the then-current budgeted amount of Development Costs and/or General Costs for any specific calendar year under the applicable Development Budget, Operations Budget or Commercialization Budget or the amounts estimated under Sections
7.2.1 (Partner Costs) and 7.2.2 (Amgen Costs); or (iv) a change to a Development Plan (including any plans with respect to a contemplated Regulatory Approval set forth therein) or Brand Plan that would, based upon [*], result in [*] of a
Product for any specific calendar year under the applicable Development Plan or Brand Plan; (B) agreement of the initial Commercialization Budget for each Product; (C) agreement of the initial Brand Plan (or material updates thereto
reflecting the launch of a new indication), Global Payer Plan and any Access and Pricing Plan for each Product; and (D) deadlocks with respect to the approval of an annual Development Budget, Operations Budget or Commercialization Budget as
provided for under Section 7.7 (Budget Deadlocks). 

  

	1.39.	 “Defending Party” has the meaning set forth in Section 13.4 (Defense of Third Party Claims). 

 

	1.40.	 “Designated Amgen Activities” means those development, regulatory, manufacturing, access and commercial activities for which Amgen
is responsible pursuant to this Agreement, including such activities allocated to it by any of the committees and teams established under this Agreement. 

 

	1.41.	 “Designated Partner Activities” means those development, regulatory, manufacturing, access and commercial activities for which
Partner is responsible pursuant to this Agreement, including such activities allocated to it by any of the committees and teams established under this Agreement. 

 

	1.42.	 “Designated Regulatory Party” has the meaning set forth in Section 3.2.1 (Designated Regulatory Party).

  

	1.43.	 “Detail” means an interactive face-to-face visit by a sales representative with a medical professional having prescribing authority
or who is able to influence prescribing decisions, within the target audience during which approved uses, safety, effectiveness, 

  
 4 

	 	 
contraindications, side effects, warnings or other relevant characteristics of a pharmaceutical product are discussed in an effort to increase prescribing preferences of a pharmaceutical product
for its approved uses. Detail includes First Position Details, Second Position Details and Other Details. Details will not include (i) activities conducted by medical support staff (such as medical science liaisons) or (ii) E-details,
activities conducted at conventions or similar gatherings and activities performed by market development specialists, managed care account directors and other personnel not performing face-to-face sales calls or not specifically trained with respect
to a pharmaceutical product. “Detailing” means the act of performing Details and to “Detail” means to perform Details. 

 

	1.44.	 “Development Budget” has the meaning set forth in Section 2.4.1.1. The initial Development Budgets will be agreed in writing
by the Parties as soon as reasonably practicable on or after the Effective Date. 

  

	1.45.	 “Development Costs” means with respect to all Products: 

 

	 	1.45.1.	 all Costs associated with obtaining, maintaining and renewing Regulatory Filings and Regulatory Approvals pertaining to a Product in accordance with
the applicable Development Plan; 

  

	 	1.45.2.	 all Costs incurred by the Parties or their respective Affiliates in performing activities designated to the Parties under the applicable Development
Plan, as applicable (including the Costs of clinical trials and related support to obtain marketing approval for a Product and other lifecycle management activities as well as Phase 4 Trials, development of related devices, observational research
and any economic value evidence generation in support of reimbursement activities such as health technology assessment submissions); 

  

	 	1.45.3.	 all manufacturing Costs not otherwise included in Manufacturing Standard Cost or Manufacturing Actual Costs, including stability testing and other
CMC support costs for such Products, Costs relating to the development of manufacturing processes, scale-ups, validations and technology transfers for Products; 

 

	 	1.45.4.	 for any clinical supply of Products, (i) the Manufacturing Standard Cost, if it is manufactured in the Manufacturing Lead’s (or its
designee’s) clinical manufacturing facility, or (ii) all Manufacturing Actual Costs, if it is manufactured in the Manufacturing Lead’s (or its designee’s) non-clinical (i.e., commercial) manufacturing facility;

  

	 	1.45.5.	 all Costs for other materials (such as non-Party comparator drugs and placebo) obtained for use in clinical trials of or related to a Product; and

  

	 	1.45.6.	 all Costs associated with engineering, conformance, or other manufacturing activities required to achieve commercial scale production of a Product,
CMC filing requirements, and the like not otherwise included in Manufacturing Actual Costs for such Product. 

 All to the extent incurred after the Effective Date. For clarity, Development Costs are exclusive of and do not include General Costs. Except to the extent already included in overhead, Development Costs
shall not include either 

  
 5 

 
Party’s Costs to the extent they solely relate to legal, accounting, finance or alliance management activities associated with overseeing execution of and compliance with this Agreement.

  

	1.46.	 “Development Lead” has the meaning set forth in Section 3.1.2 (Development Lead). 

 

	1.47.	 “Development Plan” means the plan approved by the JSC for each Product (which plan will be updated annually and will cover a period
of at least [*] years) covering: (i) the research and development (including Phase 4 Trials) of the Products in the Collaboration Scope, including observational research and payer evidence generation including economic value; (ii) the
preparation and submission of Regulatory Filings; and (iii) the obtaining, maintenance or expansion of Regulatory Approvals of the Products in the Collaboration Scope. The initial Development Plans covering calendar years [*] will be agreed in
writing by the Parties as soon as reasonably practicable on or after the Effective Date. 

  

	1.48.	 “Distracting Product” means, with respect to a given Product, any product, [*], directed at [*] the Product Target or any
Distracting Target [*]. For clarity, a [*] antibody that binds to [*] shall be a Distracting Product unless the Parties agree otherwise. 

  

	1.49.	 “Distracting Program” means the clinical development, manufacture or commercialization (including Detailing, selling, promoting or
distributing) of any Distracting Product. 

  

	1.50.	 “Distracting Target” has the meaning set forth on the Distracting Product Schedule. 

 

	1.51.	 “Distracting Transaction” means any transaction entered into by a Party or its Affiliates on or after the Effective Date whereby a
Third Party that is engaged in a Distracting Program becomes an Affiliate of a Party or any of its Affiliates. 

  

	1.52.	 “Distracting Transaction Party” has the meaning set forth in Section 9.3.3 (Inclusion). 

 

	1.53.	 “Distribution Party” has the meaning set forth in Section 4.4 (All Sales by Distribution Party). 

 

	1.54.	 “Divest” means, with respect to any Distracting Program, the sale, exclusive license or other transfer of all right, title and
interest in and to such Distracting Program, including technology, intellectual property and other assets materially relating thereto, to a Third Party, without the retention or reservation of any rights or interest (other than an economic interest,
reversion rights or other similar rights typical of a licensor in an exclusive license agreement) in such Distracting Program by such Party or its Affiliates. 

 

	1.55.	 “Early Stage Programs” has the meaning set forth in Section 4.1 (Allocation of Manufacturing Responsibility).

  

	1.56.	 “Effective Date” has the meaning set forth in the Preamble. 

 

	1.57.	 “Europe” means those countries, nations, states or other territories under the jurisdiction of the European Medicines Agency (or
any successor agency thereto), as such jurisdiction may change from time to time, and Iceland, Liechtenstein, Norway and Switzerland. 

  

	1.58.	 “Excluded Territory” means (i) with respect to AMG557, Japan, and (ii) with respect to AMG827, all countries not included
within the AMG827 Territory. 

  
 6 

	1.59.	 “Excluded Territory Agreement” means (i) in relation to AMG827, the AMG827 Technology Transfer Agreement by and among Kyowa
Hakko Kirin Co., Ltd., Amgen and Kirin-Amgen, Inc., the Research, Development and Technology Disclosure Agreement: AMG827 by and among Kyowa Hakko Kirin Co., Ltd., Amgen and Kirin-Amgen, Inc., and the AMG827 License Agreement between Kirin-Amgen,
Inc., all dated October 29, 2010 and (ii) in relation to AMG557, means the License Agreement by and between Amgen and Takeda Pharmaceutical Company Limited dated February 1, 2008, in each case as the same have been amended and may be
amended from time to time hereafter in accordance with terms of this Agreement. 

  

	1.60.	 “First Position Detail” means a Detail in which the applicable pharmaceutical product is Detailed before any other product and/or
the predominant portion of time is devoted to the Detailing of such pharmaceutical product. 

  

	1.61.	 “Force Majeure” has the meaning set forth in Section 15.7 (Force Majeure). 

 

	1.62.	 “FTE” means, with respect to a person (other than an employee that Details a Product), the equivalent of the work of one
(1) employee full time for one (1) year (consisting of at least a total of [*] weeks or [*] hours per year (excluding vacations and holidays)). Overtime, and work on weekends, holidays and the like [*] be counted [*] toward the number
of hours that are used to calculate the FTE contribution. For an employee that Details a Product, FTEs will be calculated as set forth in Section 7.2.11 (Calculation of Sales Force Costs). 

 

	1.63.	 “FTE Rate” means, for the period commencing on the Effective Date until such time as the Parties agree otherwise, (i) [*]
for activities conducted in the U.S., and (ii) for all other geographic locations [*] multiplied by a cost of living adjustment between the U.S. and such other geographic location as set forth in the then most current edition of [*] (or in the
event such geographic location is not listed, the nearest listed geographic location that is most comparable to such non-listed geographic location). The FTE Rate will be increased by [*]. The FTE Rate shall include costs of salaries, benefits,
supplies, other employee costs, facility costs, depreciation and supporting general and administration allocations. 

  

	1.64.	 “GAAP” means the then-current generally accepted accounting principles in the United States as established by the Financial
Accounting Standards Board or any successor entity or other entity generally recognized as having the right to establish such principles in the United States, in each case consistently applied. 

  
 7 

	1.65.	“General Costs” means with respect to all Products: 

  

	 	1.65.1.	 all Costs, other than Amgen Sales Force Costs and Partner Sales Force Costs, associated with activities related to the commercialization of
Products, including: sales, pricing, access, coverage (including risk sharing arrangements), reimbursement, presentation, purchase of ancillary items or devices, contracting, launch timing, distribution, marketing messaging, product positioning,
development of training materials, sales tracking and auditing, market research and product usage surveys, provision of medical affairs support staff, and scientific and medical advisory boards (including any global medical conferences);

  

	 	1.65.2.	 all Amgen Sales Force Costs and Partner Sales Force Costs incurred in accordance with the Brand Plan and calculated in accordance with
Section 7.2.11 (Calculation of Sales Force Costs); 

  

	 	1.65.3.	 all training Costs incurred in accordance with Section 5.5 (Training); 

 

	 	1.65.4.	 all defense, enforcement and cooperation Costs incurred within or materially related to the Collaboration Scope in accordance with Section 10.7
(Defense and Settlement of Third Party Claims), Section 13.4 (Defense of Third Party Claims) and Section 10.8 (Enforcement) ([*]); 

  

	 	1.65.5.	 all Costs with respect to product liability claims for Products in the Collaboration Scope [*]; 

 

	 	1.65.6.	 all Costs associated with any recalls, returns and withdrawals of a Product in the Collaboration Scope ([*]); 

 

	 	1.65.7.	 all Costs incurred in connection with Prosecution and Maintenance of Amgen Intellectual Property and Program Intellectual Property in accordance
with Section 10.6 (Prosecution and Maintenance) within or materially related to the Collaboration Scope; 

  

	 	1.65.8.	 all Manufacturing Actual Costs for any samples of Products provided in the Collaboration Scope; 

 

	 	1.65.9.	 for any commercial supply of Products, all Manufacturing Actual Costs for Products sold; 

 

	 	1.65.10.	             all manufacturing Costs not otherwise included in Manufacturing Actual
Costs, including stability testing and other CMC support costs for such Products, but only to the extent such costs are not included in Development Costs under Section 1.45.3; and 

 

	 	1.65.11.	             any amounts paid by either Party to Third Parties for rights to manufacture,
use or sell a Product in or for the Collaboration Scope to the extent not already included in Manufacturing Actual Costs; provided, that [*]. 

 All to the extent incurred after the Effective Date. For clarity, General Costs are exclusive of and do not include Development Costs. Except to the extent already included in overhead, General Costs
shall not include either Party’s Costs to the extent they solely relate to legal, accounting, finance or alliance 

  
 8 

 
management activities associated with overseeing execution of and compliance with this Agreement. 
  

	1.66.	 “Global Payer Plan” means the global plan for a Product approved by the JSC that sets forth the strategic direction, positioning,
value proposition and reimbursement for such Product. 

  

	1.67.	 “Governmental Authority” means any government or supranational administrative agency, commission or other governmental or
supranational authority, body or instrumentality, or any federal, state, local, domestic or foreign governmental or supranational regulatory body. 

  

	1.68.	 “Government Official” means (i) any Person employed by or acting on behalf of a Governmental Authority; (ii) any
political party, party official or candidate; (iii) any Person who holds or performs the duties of an appointment, office or position created by custom or convention; and (iv) any Person who holds himself out to be the authorized
intermediary of any of the foregoing. 

  

	1.69.	 “Housemarks” means the Amgen Housemarks or the Partner Housemarks, as the case may be. 

 

	1.70.	 “IFRS” means the then-current International Financial Reporting Standards, consistently applied. 

 

	1.71.	 “Indemnified Party” has the meaning set forth in Section 13.3 (Claim for Indemnification). 

 

	1.72.	 “Indemnifying Party” has the meaning set forth in Section 13.3 (Claim for Indemnification). 

 

	1.73.	 “Indirect Taxes” means VAT, sales taxes, consumption taxes and other similar taxes. 

 

	1.74.	 “Infringement Claim” has the meaning set forth in Section 10.7 (Defense and Settlement of Third Party Claims of Infringement).

  

	1.75.	 “Invention” means any idea, concept, discovery, invention, improvement or trade secret. 

 

	1.76.	 “Inventorship Margin” has the meaning set forth in Section 7.2.8.2 (Profit). 

 

	1.77.	 “Joint Claim” has the meaning set forth in Section 13.4 (Defense of Third Party Claims). 

 

	1.78.	 “Joint Product Team” or “JPT” means the individual Product teams established pursuant to Article 2 (Scope and
Governance). 

  

	1.79.	 “Joint Steering Committee” or “JSC” means the steering committee established pursuant to Article 2 (Scope and
Governance). 

  
 9 

	1.80.	 “Key Regulatory Filings” means any (i) Investigational New Drug Application (or similar filing outside the United States);
(ii) Biologic Licensing Application (or similar filing outside the United States); (iii) briefing books; and (iv) any other Regulatory Filing designated a Key Regulatory Filing by written agreement of the
Parties.

  

	1.81.	 “Know-How” means all tangible and intangible techniques, information, technology, practices, trade secrets, Inventions (whether
patentable or not), methods, processes, knowledge, know-how, conclusions, skill, experience, test data and results (including pharmacological, toxicological, manufacturing, and clinical test data and results), regulatory documentation, analytical
and quality control data, results or descriptions, software and algorithms, including works of authorship and Copyrights, and materials, including biological materials, compositions and the like. Know-How does not include Patents, Product
Trademarks, Amgen Housemarks, Partner Housemarks, or Program Patents and Trademarks. 

  

	1.82.	 “Losses” has the meaning set forth in Section 13.1 (Indemnity by Partner). 

 

	1.83.	 “Manufacturing Actual Costs” means (i) [*]. Manufacturing Actual Costs will be calculated consistently with other products
manufactured by the Manufacturing Lead and in accordance with GAAP or IFRS, as applicable. For clarity, in the event that the Manufacturing Lead uses a contract manufacturer to perform any manufacturing activities under this Agreement, Manufacturing
Actual Costs for such activities will be the price the Manufacturing Lead pays such contract manufacturer for such activities, plus the Costs to manage and to process materials obtained from such contract manufacturer. 

 

	1.84.	 “Manufacturing Lead” has the meaning set forth in Section 4.2 (Manufacturing Lead). 

 

	1.85.	 “Manufacturing Standard Costs” means, with respect to a Product, [*]. For clarity, (i) where Amgen is the Manufacturing Lead,
Amgen’s internal clinical standard cost methodology for clinical product [*], and (ii) in the event that the Manufacturing Lead uses a contract manufacturer to perform any manufacturing activities under this Agreement, Manufacturing
Standard Cost for such activities will be the price the Manufacturing Lead pays such contract manufacturer for such activities, plus the Costs to manage and to process materials obtained from such contract manufacturer. 

 

	1.86.	 “Material Anti-Corruption Law Violation” means a violation of an Anti-Corruption Law relating to the subject matter of this
Agreement which would if it were publicly known, in the reasonable view of a Party, have a material adverse effect on it or on its reputation because of its relationship with the other Party. 

 

	1.87.	 “Medarex Agreement” means that certain Research and Commercialization Agreement by and among Medarex, Inc., GenPharm International,
Inc. and Amgen dated as of December 23, 2002. 

  

	1.88.	 “[*]” means Partner’s proprietary antibody [*] that is currently in clinical development. 

 

	1.89.	 “Net Revenues” means: (i) the aggregate of the gross invoiced sales prices for Products that are sold or transferred for value
by either Party or their respective Affiliates to Third Parties in the Collaboration Territory, minus the following amounts incurred or paid (each as recognized by GAAP or IFRS, as applicable, and each to the

  
 10 

 
extent not already deducted when calculating Manufacturing Actual Costs) by such selling Party or its Affiliates with respect to such sales or transfers for value (regardless of the period in
which such amounts are incurred or paid): 
  

	 	1.89.1.	 trade, cash, prompt payment or quantity discounts; 

 

	 	1.89.2.	 payments to Governmental Authorities, returns, refunds, allowances, rebates and chargebacks; 

 

	 	1.89.3.	 retroactive price reductions applicable to sales of such Product; 

 

	 	1.89.4.	 fees paid to distributors, wholesalers, selling agents (excluding any sales representatives of a Party or any of its Affiliates), group purchasing
organizations and managed care entities; 

  

	 	1.89.5.	 the standard inventory cost (actual acquisition or manufacture cost) of devices used for dispensing or administering such Product that are shipped
with such Product and included in the gross invoiced sales prices; 

  

	 	1.89.6.	 credits or allowances for product replacement, whether cash or trade; 

 

	 	1.89.7.	 any tax, tariff, duty or governmental charge levied on the sales, transfer, transportation or delivery of such Product (including any tax such as a
value added or similar tax or government charge), other than franchise or income tax of any kind whatsoever; 

  

	 	1.89.8.	 [*]; 

  

	 	1.89.9.	 [*]; and 

  

	 	1.89.10.	             any import or export duties or their equivalent borne by the relevant
seller; 

 plus (ii) any Recoveries made pursuant to Section 10.8 (Enforcement).

  

	1.90.	 “Non-Suspending Party” has the meaning set forth in Section 7.8 (Program Recommitment). 

 

	1.91.	 “North America” means the United States and Canada. 

 

	1.92.	 “[*]” has the meaning set forth in Section 7.2.8.1.2 (Quarterly Cap). 

 

	1.93.	 “Operations Budget” has the meaning set forth in Section 2.4.1.2. The initial Operations Budgets will be agreed in writing by
the Parties as soon as reasonably practicable on or after the Effective Date. 

  

	1.94.	 “Other Detail” means any Detail other than a First Position Detail or a Second Position Detail. 

 

	1.95.	 “Out-License Election” has the meaning set forth in Section 7.8.2.4 (Out-License). 

 

	1.96.	 “Partner” has the meaning set forth in the Preamble. 

 

	1.97.	 “Partner Costs” has the meaning set forth in Section 7.2.1 (Partner Costs). 

 

	1.98.	 “Partner Housemarks” means (i) the corporate logo of Partner, (ii) the trademark “AstraZeneca” and
“MedImmune”, (iii) any other trademark, trade name or service mark (whether registered or unregistered) containing the word “AstraZeneca” or 

  
 11 

 
“MedImmune”, and (iv) any other trademark or service mark associated with goods or services of Partner or its Affiliates, but excluding the Product Trademarks and trademarks, trade
names or service marks associated with goods or services outside the scope of this Agreement; and all intellectual property rights residing in any of the foregoing. 
  

	1.99.	 “Partner Indemnitees” has the meaning set forth in Section 13.2 (Indemnity by Amgen). 

 

	1.100.	 “Partner Intellectual Property” means any Know-How, Patents, electronic media registrations (including domain names, usernames,
websites, blogs and the like), or Copyright controlled by Partner or its Affiliates that is used (but is not generated or conceived) during the Term by either Party or its Affiliates in the performance of this Agreement. Partner Intellectual
Property specifically excludes Program Intellectual Property. 

  

	1.101.	 “Partner Sales Force Costs” means the allocable share of Partner’s (or its Affiliates’) costs for sales representatives
that Detail Products in the Collaboration Scope in accordance with this Agreement, calculated in accordance with Section 7.2.11 (Calculation of Sales Force Costs). 

 

	1.102.	 “Party” or “Parties” has the meaning set forth in the Preamble. 

 

	1.103.	 “Party Representatives” has the meaning set forth in Section 12.3.3. 

 

	1.104.	 “Patent Coordinator” means those employees of each of the Parties appointed pursuant to Section 2.10 (Patent Coordinators) to
serve as each such Party’s primary liaison with the other Party on matters relating to intellectual property as described in this Agreement. 

  

	1.105.	 “Patent Extensions” has the meaning set forth in Section 10.9 (Patent Term Extensions). 

 

	1.106.	 “Patents” means the issued patents and pending patent applications (including certificates of invention, applications for
certificates of invention and priority rights) in any country or region, including all provisional applications, refilings, substitutions, continuations, continuations-in-part, divisions, renewals, all letters patent granted thereon, and all
reissues, re-examinations and patent term extensions thereof, and all international or foreign counterparts of any of the foregoing (including supplemental protection certificates, patents of addition and the like). 

  
 12 

	1.107.	 “Person” means an individual, corporation, partnership, limited liability company, limited partnership, trust, business trust,
association, joint stock company, joint venture, pool, syndicate, “group” as defined in Section 13(d)(3) of the Securities Exchange Act of 1934, as amended, sole proprietorship, unincorporated organization, Governmental Authority or
any other form of entity not specifically listed herein. 

  

	1.108.	 “Phase 1 Trial” means a clinical trial of a pharmaceutical product that meets the definition of a Phase 1 study for the United
States as described in 21 C.F.R. §312.21(a), or its successor regulation, or the equivalent regulation in any other country, including the Phase 1 part of any clinical trial that is a combination Phase 1 Trial and Phase 2 Trial. A
“Phase 1(b) Trial” means a Phase 1 Trial that is designed to demonstrate evidence of clinical impact. 

  

	1.109.	 “Phase 2 Trial” means a clinical trial of a pharmaceutical product that meets the definition of a Phase 2 study for the United
States as described in 21 C.F.R. §312.21(b), or its successor regulation, or the equivalent regulation in any other country. 

  

	1.110.	 “Phase 3 Trial” means a clinical trial of a pharmaceutical product that meets the definition of a Phase 3 study for the United
States as described in 21 C.F.R. §312.21(c), or its successor regulation, or the equivalent regulation in any other country. 

  

	1.111.	 “Phase 4 Trial” means any clinical study initiated in the Collaboration Territory for a Product following the first Regulatory
Approval for the sale of such Product in the Collaboration Scope for the indication being studied. Phase 4 Trials may include epidemiological studies, modeling and pharmacoeconomic studies, and post-marketing surveillance studies, as well as any
clinical study or research study sponsored and conducted by an individual not employed by or on behalf of either Party. 

  

	1.112.	 “Product” means any pharmaceutical product containing one of the pharmaceutical compounds listed on the Products Schedule [*].

  

	1.113.	 “Product Intellectual Property” means Amgen Intellectual Property, Partner Intellectual Property, and Program Intellectual
Property. 

  

	1.114.	 “Product Target” has the meaning set forth on the Distracting Product Schedule. 

 

	1.115.	 “Product Trademarks” means any trademark, trade name or service mark (whether registered or unregistered) selected by the JPT for
use on, with, or to refer to a Product (other than Amgen Housemarks and Partner Housemarks, as applicable) or used with patient support or other information or services or Promotional Materials associated with a Product in the Collaboration
Territory during the Term, and all intellectual property rights residing in the foregoing. 

  

	1.116.	 “Program Intellectual Property” means any Know-How, Patents, Product Trademark, trademark application, electronic media
registrations (including domain names, usernames, websites, blogs and the like), or Copyright generated or conceived by Amgen, Partner or their respective Affiliates, whether solely or jointly (or together with a Third Party), during the Term as a
result of carrying out the Designated Amgen Activities or the Designated Partner Activities, as applicable. 

  
 13 

	1.117.	 “Program Notice” has the meaning set forth in Section 9.4 (Pre-Clinical Research and Development Programs).

	1.118.	 “Program Patents and Trademarks” has the meaning set forth in Section 10.6.3 (Program Intellectual Property).

  

	1.119.	 “Promotional Materials” has the meaning set forth in Section 5.7 (Promotional Materials). 

 

	1.120.	 “Prosecution and Maintenance” means the preparation, filing, and prosecution of patent applications and maintenance of patents, as
well as re-examinations and reissues with respect to such patents, together with the conduct of interferences, post–grant proceedings (including without limitation post-grant review, inter-partes review, and derivation proceedings in the U.S.)
and the defense of oppositions with respect to such patent application or patent; and “Prosecute and Maintain” has the correlative meaning. 

 

	1.121.	 “Quarterly Cap” has the meaning set forth in Section 7.2.8.1.2 (Quarterly Cap). 

 

	1.122.	 “Quality Agreement” means that certain Quality Agreement dated as of the date hereof between the Parties (and substantially in the
form attached hereto as the Quality Agreement Schedule) regarding the clinical use of Products manufactured by Amgen, and any subsequent quality agreements between the Parties related to Products supplied pursuant to this Agreement.

  

	1.123.	 “Recoveries” means all monies received by either Party from a Third Party in connection with the final, non-appealable judgment (or
judgment with respect to which the time period for appeal has expired), award or settlement of any enforcement with respect to any Product Intellectual Property, to the extent such judgment, award or settlement pertains to activities within the
Collaboration Scope. 

  

	1.124.	 “Re-Entry Notice” has the meaning set forth in Section 7.8.2.1 (Re-Entry Period). 

 

	1.125.	 “Re-Entry Period” has the meaning set forth in Section 7.8.2.1 (Re-Entry Period). 

 

	1.126.	 “Regulatory Approval” means an approval for a Product from a Governmental Authority necessary for the research, development,
manufacture, distribution, pricing, reimbursement, marketing or sale of such Product. 

  

	1.127.	 “Regulatory Filing” means any filing with any Governmental Authority with respect to the research, development, manufacture,
distribution, pricing, reimbursement, marketing or sale of a Product. 

  

	1.128.	 “Reimbursed Development Costs” means any Development Costs incurred by either Party for which Amgen is entitled to reimbursement
from a Third Party pursuant to the Excluded Territory Agreements; provided, that [*] shall not be a Reimbursed Development Cost. 

  

	1.129.	 “Researching Party” has the meaning set forth in Section 9.4 (Pre-Clinical Research and Development Programs).

  
 14 

	1.130.	 “Safety Agreement” means that certain Safety Agreement to be entered into between the Parties within ninety (90) days of the
Effective Date regarding adverse event reporting with respect to Products manufactured by Amgen, and any subsequent safety agreements between the Parties related to Products supplied pursuant to this Agreement. 

 

	1.131.	 “Second Position Detail” means a Detail in which the applicable pharmaceutical product is Detailed in the second position (i.e., no
more than one (1) other product is presented to or discussed with the healthcare professional before such Product) and/or the second most predominant portion of time is devoted to the Detailing of such pharmaceutical product.

  

	1.132.	 “Segregate” means, with respect to two (2) programs: (i) to restrict and prevent all program-related contacts and
communications between personnel (whether employees, consultants, Third Party contractors or otherwise and whether or not located within the Collaboration Territory (for the purposes of this definition, “Personnel”)) working on or
involved with the development or commercialization of the first program and Personnel working on or involved with the development or commercialization of the second program; (ii) to ensure that Personnel that are working on the first program
will not simultaneously work on the second program and vice versa; (iii) to ensure that confidential information relating to the first program is not shared with or accessed by Personnel that are working on the second program and vice versa;
and (iv) from time-to-time, upon the reasonable request of the other Party, to provide information requested relating to the foregoing items (i) through (iii), and to reasonably cooperate to enable the other Party to verify that such
restrictions are in place and sufficient to achieve the foregoing. For clarity, [*] as set forth herein. 

  

	1.133.	 “Specifications” has the meaning set forth in the applicable Quality Agreement. 

 

	1.134.	 “Stage 1 Clinical Trial” means, with respect to each Product, the trial or trials set forth in the Stage 1 Clinical Trial Schedule.

  

	1.135.	 “Stage 2 Clinical Trial” means, with respect to each Product, the trial or trials mutually agreed upon by the Parties at such time
either Party provides a Suspension Election with respect to such Product under Section 7.8.1.1 (Suspension Election) (provided, that if the Parties are unable to agree upon such trial or trials, then Stage 2 Clinical Trial shall be
deemed to be first study in the next phase of development (i.e., the first Phase 3 Trial if the Stage 1 Clinical Trial was a Phase 2b Trial, the first Phase 2b Trial if it were a Phase 2a Trial, the first Phase 2a Trial if it were a Phase 1b Trial,
etc.). 

  

	1.136.	 “Sublicensing Revenue” means with respect to any Terminated Products, all cash payments (and the fair market value of all non-cash
consideration) received by the Continuing Party and/or any of its Affiliates from any Third Party in consideration for a transaction, series of transactions or other arrangement in which such Third Party obtains a license (or sublicense) of the
Product Intellectual Property (or any option or other right to obtain a license of the Product Intellectual Property), including, without limitation, up-front payments, milestones, royalties, and research funding (provided, that with respect
to research funding payments, only the amounts in excess of the Continuing Party’s external costs and internal costs directly related to such research activities will be included). 

  
 15 

	1.137.	 “Suspending Party” has the meaning set forth in Section 7.8 (Program Recommitment). 

 

	1.138.	 “Suspension Election” has the meaning set forth in Section 7.8.1.1 (Suspension Election). 

 

	1.139.	 “Taxes” means any tax, excise or duty, other than taxes and withholdings upon income. 

 

	1.140.	 “Technical Feasibility” means, with respect to any Product manufactured, the first date on which, in the good-faith determination
of the Manufacturing Lead, there is a high probability that (i) such related Product candidates will obtain Regulatory Approval for the sale of such Product candidate and (ii) the related costs will be recoverable through the
commercialization of such manufactured Product. 

  

	1.141.	 “Term” means the period commencing on the Effective Date and continuing in perpetuity, unless and until earlier terminated pursuant
to any provision of this Agreement. 

  

	1.142.	 “Termination Election” has the meaning set forth in Section 7.8.1.4 (Subsequent Termination). 

 

	1.143.	 “Third Party” means any Person that is not a Party, or an Affiliate of a Party. 

 

	1.144.	 “Third Party Claim” means any claim, action, lawsuit, or other proceeding brought by any Third Party. Third Party Claim
includes any Infringement Claim. 

  

	1.145.	 “Total Costs” means all General Costs, Unreimbursed Development Costs and Reimbursed Development Costs.

  

	1.146.	 “United States” or “U.S.” means the United States of America and its territories and possessions.

  

	1.147.	 “Unreimbursed Development Costs” means any Development Costs incurred by either Party for which Amgen is not entitled to
reimbursement from a Third Party pursuant to the Excluded Territory Agreements; provided, that [*] shall be an Unreimbursed Development Cost. 

  

	1.148.	 “VAT” means the tax imposed by Council Directive 2006/112/EC of the European Community and any national legislation implementing
that directive together with legislation supplemental thereto and in particular, in relation to the United Kingdom, the tax imposed by the Value Added Tax Act of 1994 or other tax of a similar nature imposed in other countries in the Collaboration
Territory. 

  

	1.149.	 “Withholding Party” has the meaning set forth in Section 8.6.1 (Withholding). 

  
 16 

 2.     SCOPE AND GOVERNANCE 

 

	2.1.	 Purpose of the Collaboration. The purpose of the collaboration is for the Parties to collaborate in the development, manufacture and
commercialization of the Products and for the Parties to share in certain costs and revenues related to the Products, all as described in more detail herein. 

 

	2.2.	 Ex-Territory Activities. 

  

	 	2.2.1.	 No Rights in Excluded Territory. The Parties acknowledge that no rights are granted hereunder to Partner with respect to the applicable
Product in any country in the Excluded Territory, and that Partner will have no authority with respect to the research, development, manufacture or commercialization of such applicable Products in the Excluded Territory. As between the Parties,
Amgen or its licensees will have the sole right to research, develop, manufacture and commercialize such Products in the Excluded Territory. Partner hereby acknowledges that (i) Amgen has previously licensed rights for AMG557 in Japan to Takeda
Pharmaceutical Company Limited, and (ii) Amgen obtained its rights for AMG827 under license from Kirin-Amgen, Inc. and its right to develop, manufacture and commercialize AMG827 is subject to certain agreements between Amgen and Kirin-Amgen,
Inc. 

  

	 	2.2.2.	 License Grant by Partner. To the extent Amgen is required under any Excluded Territory Agreement to grant rights to a Third Party under any
intellectual property rights, Know-How, Regulatory Filings or Regulatory Approvals with respect to a Product in the Excluded Territory, Partner hereby grants Amgen a license (with the right to sublicense) in and to any Partner Intellectual Property,
Program Intellectual Property, Know-How, Regulatory Filings or Regulatory Approvals as necessary for Amgen to comply with its obligations under any such Excluded Territory Agreement. 

 

	 	2.2.3.	 Kirin-Amgen Royalty Payments. Additionally, any royalties payable to Kirin-Amgen, Inc. with respect to AMG827 under an Excluded Territory
Agreement shall be paid directly by Amgen and shared by the Parties in a manner consistent with Section 7.2.8.2 (Profit). 

  

	 	2.2.4.	 Subsequent Rights in Excluded Territory. If Amgen obtains the right to develop and commercialize Products in all or part of the Excluded
Territory, then, upon the request of Partner (made no later than sixty (60) days following receipt of written notice from Amgen regarding such Excluded Territory rights), Amgen and Partner will enter into good faith discussions for the
inclusion of such rights under this Agreement on terms to be agreed by Parties (provided, that if the Parties are unable to agree upon such terms within [*] of the initiation of such discussions, Amgen shall be free to develop and
commercialize Products in such Excluded Territory itself or with a Third Party). 

  

	 	2.2.5.	 Prior Consultation. Amgen will consult with Partner in advance with respect to: (i) [*]; (ii) [*]; and (iii) [*].

  

	2.3.	Committees and Teams. 

  
 17 

	 	2.3.1.	 Formation. Promptly but not later than sixty (60) days following the Effective Date, the Parties will establish (i) a single,
cross-functional Collaboration Review Committee; (ii) a single, cross-functional Joint Steering Committee; and (iii) a cross-functional Joint Product Team for each Product. The JSC and each JPT will each have the right to establish
subcommittees or working teams with respect to issues within its area of responsibility as it sees fit (e.g., development, regulatory, pricing, access, manufacturing, commercial or operations), including local or regional
commercialization/operations teams to facilitate the performance of its responsibilities or a finance team to facilitate the implementation of the cost allocations provided in this Agreement. 

 

	 	2.3.2.	 Membership. The CRC will be comprised of three (3) members appointed by each of the Parties or such other number of members as agreed by
the Parties (with representatives from each Party for each of development, manufacturing and commercialization). The JSC will be comprised of five (5) members appointed by each of the Parties or such other number of members as agreed by the
Parties. The CRC and JSC will each be led by two (2) co-chairs, one (1) appointed by each of the Parties. Each Party will designate such number of members to each JPT as it deems appropriate in order to accomplish the activities for which
it is responsible. Each Party will ensure that the CRC, JSC and JPT members appointed by it have (i) the appropriate level of seniority and decision-making authority commensurate with the responsibilities of the committee or team to which they
are appointed, and (ii) a range of expertise in the development, manufacture and commercialization of therapeutic products to enable an efficient cross-functional committee or team structure. Each Party will have the right to replace its
committee or team members by written notice to the other Party. In the event any committee or team member becomes unwilling or unable to fulfill his or her duties hereunder, the Party that appointed such member will promptly appoint a replacement by
written notice to the other Party. 

  

	 	2.3.3.	 Meetings. The CRC will meet semi-annually, via teleconference or videoconference or otherwise (with at least one (1) meeting per
calendar year being in person), or as otherwise agreed by the Parties. Additionally, either Party may request a meeting of the CRC to resolve any Critical Matters requiring resolution. The JSC will meet quarterly, via teleconference or
videoconference or otherwise (with at least one (1) meeting per calendar year being in person and with at least one (1) meeting per calendar year being scheduled as appropriate to approve [*]), or as otherwise agreed by the Parties. Each
JPT and each subcommittee and working team established hereunder will establish a meeting frequency and meeting protocol necessary to coordinate and conduct the activities for which it is responsible, as agreed by the Parties. Any in-person meetings
of the CRC or JSC will be held on an alternating basis between Partner’s and Amgen’s headquarters, unless otherwise agreed by the Parties. Each Party will be responsible for its own expenses relating to such meetings. As appropriate, other
employee representatives of the Parties may attend such meetings as non-voting participants, but no Third Party personnel may attend unless otherwise agreed by the Parties. Either Party may also call

  
 18 

	 	 
for special meetings of the CRC and JSC as reasonably required to resolve a Critical Matter escalated to the CRC or JSC pursuant to Section 2.4.2 (JPT Deadlocks) or 2.5.2 (JSC Deadlocks)
below; provided, that the requesting Party provides at least ten (10) business days’ prior written notice to the co-chair of such committee appointed by the other Party and such notice includes a proposed agenda for such meeting.
All committee and team meetings must have at least two (2) members appointed by each Party in attendance. All committee and team meetings will be conducted in English, and all documents (including Development Plans, Development Budgets,
clinical trial protocols for the Products, Operations Budgets, Brand Plans and Commercialization Budgets) will be in English. 

  

	 	2.3.4.	 Decision-Making. Subject to the terms of this Agreement (including Sections 2.4.2 (JPT Deadlocks) and 2.5.2 (JSC Deadlocks) below), the
decisions of the CRC, JSC, JPTs and any subcommittees and working teams established hereunder will be made by consensus of the members thereof, with each Party having one (1) vote. 

 

	2.4.	Joint Product Teams. 

  

	 	2.4.1.	 Responsibilities. Except for decisions expressly reserved to the JSC or CRC pursuant to Section 2.5 (Joint Steering Committee) or 2.6
(Collaboration Review Committee), respectively, each JPT will (i) establish subcommittees and working teams as necessary to coordinate and conduct its activities hereunder; (ii) coordinate with and oversee the activities of any such
subcommittees and working teams; and (iii) be responsible for all operational matters regarding the development, manufacture and commercialization of the Products, including: 

 

	 	2.4.1.1.	         the following development matters: (i) developing the Development Plan for the applicable
Product in the Collaboration Territory and annual updates (or any other updates) thereto; (ii) developing the [*] expense budget for development activities to be undertaken pursuant to the collaboration (the “Development
Budget”) for such Product in the Collaboration Territory and annual updates (or any other updates) thereto; (iii) preparing all clinical trial protocols for such Product; (iv) providing for communication and discussion between the
Parties to optimize the efficacy and safety of the development of such Product in the Collaboration Territory; (v) reviewing and monitoring the activities and progress against the Development Plan, including regulatory matters, site enrollment,
patient enrollment, progress of trials, data received and data analysis; (vi) developing observational research and any payer and economic value evidence generation plans for inclusion in the Development Plan; (vii) communicating with the
Parties regarding all of the foregoing; and (viii) making such decisions as are specified in Article 3 (Development and Regulatory) to be made by the JPT; 

 

	 	2.4.1.2.	         the following operations matters: (i) overseeing supply of the applicable Product (in
accordance with the applicable Quality 

  
 19 

	 	 
Agreement); (ii) reviewing cost of goods of such Product, including yields, success rates and other relevant production statistics; (iii) preparing a draft supply forecast for such
Product; (iv) developing the [*] expense budget for manufacturing activities to be undertaken pursuant to the collaboration, including CMC, process development and device-related activities (the “Operations Budget”) for such
Product in the Collaboration Territory and annual updates (or any other updates) thereto; (v) reviewing other operational issues relating to the manufacture or supply of such Product and any related devices; and (vi) making such decisions
as are specified in Article 4 (Manufacturing) to be made by the JPT; and 

  

	 	2.4.1.3.	         the following commercialization matters: (i) preparing the Brand Plan for the applicable
Product and annual updates (or any other updates) thereto; (ii) developing the [*] expense budget for commercialization activities to be undertaken pursuant to the Brand Plans and Country Plans (the “Commercialization Budget”)
for such Product in the Collaboration Territory and annual updates (or any other updates) thereto; (iii) preparing on an annual basis a three year sales forecast for such Product; (iv) conducting consolidation of expense and sales
forecasts from the country or regional level for such Product; (v) reviewing the tactical alignment of commercialization activities with expense budget allocations; (vi) monitoring and reporting on the competitive landscape for such
Product in the Collaboration Territory; (vii) establishing a process for reviewing and approving Promotional Materials and training materials and programs for such Product; (viii) developing a global pricing policy for the applicable
Product; and (ix) making such decisions as are specified in Article 5 (Commercialization) to be made by the JPT. 

  

	 	2.4.2.	 JPT Deadlocks. If a JPT is unable to reach consensus on a non-Critical Matter, the decision will be made by the members of such JPT appointed
by: (i) the applicable Development Lead, in the case of matters under Section 2.4.1.1; (ii) the applicable Manufacturing Lead, in the case of matters under Section 2.4.1.2; and (iii) the applicable Commercialization Lead, in
the case of matters under Section 2.4.1.3. If a JPT is unable to reach consensus on a Critical Matter, the members of such JPT appointed by either Party will have the right to require that such issue be escalated to the JSC for determination;
provided, that if, in the good faith determination of the Development Lead, the Manufacturing Lead or the Commercialization Lead, as applicable, resolution of such Critical Matter requires exigent action pursuant to Applicable Law or to prevent a
material adverse effect on a Product or a Party, the members of such JPT appointed by the Development Lead, the Manufacturing Lead or the Commercialization Lead, as applicable, will have the right to make an interim decision pending JSC
determination. 

  

	2.5.	 Joint Steering Committee. 

  

	 	2.5.1.	 Responsibilities. The JSC will (i) oversee the activities of the Parties hereunder generally, each Joint Product Team and any
subcommittees or working teams 

  
 20 

	 	 
established hereunder, (ii) establish subcommittees and working teams as necessary to coordinate and conduct its activities hereunder, and (iii) be responsible for:

  

	 	2.5.1.1.	         the following development matters: (i) approving the Development Plan for each Product in the
Collaboration Territory and annual updates thereto; (ii) approving the Development Budget for each Product in the Collaboration Territory and [*] updates thereto; (iii) reviewing and approving all clinical trial protocols for the Products;
and (iv) making such decisions as are specified in Article 3 (Development and Regulatory) to be made by the JSC; 

  

	 	2.5.1.2.	         the following operations matters: (i) approving the Operations Budget for each Product in the
Collaboration Territory; (ii) approving the draft supply forecast for each Product; and (iii) making such decisions as are specified in Article 4 (Manufacturing) to be made by the JSC; and 

 

	 	2.5.1.3.	         the following commercialization matters: (i) approving the Brand Plans and integrating
such plans with the Development Plans; (ii) approving a global pricing policy for the applicable Product; (iii) reviewing sales forecasts for each Product; (iv) approving the Commercialization Budget for each Product in the
Collaboration Territory; and (v) making such decisions as are specified in Article 5 (Commercialization) to be made by the JSC. 

  

	 	2.5.2.	 JSC Deadlocks. If the JSC is unable to reach consensus on a non-Critical Matter, the decision will be made by the members of the JSC
appointed by (i) the applicable Development Lead, in the case of matters under Section 2.5.1.1; (ii) the applicable Manufacturing Lead, in the case of matters under Section 2.5.1.2; and (iii) the applicable Commercialization
Lead, in the case of matters under Section 2.5.1.3. If the JSC is unable to reach consensus on a Critical Matter, the members of the JSC appointed by either Party will have the right to require that such issue be escalated to the CRC for
determination; provided, that if, in the good faith determination of the Development Lead, the Manufacturing Lead or the Commercialization Lead, as applicable, resolution of such Critical Matter requires exigent action pursuant to Applicable
Law or to prevent a material adverse effect on a Product or a Party, the members of the JSC appointed by the Development Lead, the Manufacturing Lead or the Commercialization Lead, as applicable, will have the right to make an interim decision
pending CRC determination. 

  

	2.6.	 Collaboration Review Committee. The CRC will be responsible for (i) providing general oversight of the collaboration;
(ii) resolving any matters specifically designated to it under this Agreement; and (iii) resolving any Critical Matters escalated to it from the JSC. For clarity, all decisions of the CRC will be made by consensus of the members of the
CRC, with each Party having one (1) vote, unless expressly set forth in this Agreement to the contrary. 

  
 21 

	2.7.	 Reporting. Each Party will keep the applicable committee or team fully and promptly informed of progress and results of activities for which
it is responsible or that it is permitted to conduct hereunder through its members on such committee or team and as otherwise provided herein. 

  

	2.8.	 No Authority to Amend or Modify. Notwithstanding anything herein to the contrary, no committee or team will have any authority to amend,
modify or waive compliance with this Agreement. 

  

	2.9.	 Alliance Managers. Promptly after the Effective Date, each Party will appoint a person who will oversee interactions between the Parties
between meetings of the committees and teams established hereunder (each, an “Alliance Manager”). The Alliance Mangers will have the right to attend all meetings of the CRC, the JSC, the JPTs and any subcommittees and working teams
established hereunder, as non-voting participants at such meetings. Each Party may in its sole discretion replace its Alliance Manager at any time by notice in writing to the other Party. 

 

	2.10.	 Patent Coordinators. The Parties will each appoint a Patent Coordinator for each Product promptly after the Effective Date. The Patent
Coordinators will serve as the primary contacts and forum for discussion between the Parties with respect to intellectual property matters involving each Product worldwide, and will cooperate with respect to the activities set forth in Article 10
(Intellectual Property). For each Product, the associated Patent Coordinators will discuss a strategy with regard to Prosecution and Maintenance, defense and enforcement of Product Intellectual Property, and defense against allegations that the
activities hereunder infringe, or obtaining or amending licenses to, Third Party Patents or Know-How. The Patent Coordinators will meet as often as agreed by them (and at least semi-annually if requested), via teleconference or videoconference or as
otherwise agreed, to discuss matters arising out of the activities set forth in Article 10 (Intellectual Property). Each Party may in its sole discretion replace any of its Patent Coordinators at any time by notice in writing to the other Party.

 3.    DEVELOPMENT AND REGULATORY 

 

	3.1.	 Development Matters. 

  

	 	3.1.1.	 Allocation of Development and Regulatory Responsibility. The JSC will (i) allocate development and regulatory activities to Amgen or
Partner on a country-specific or activity-specific basis, taking into consideration all relevant factors (including the strategic objectives and capabilities of each Party) and (ii) determine whether operational responsibility for any such
activity should be transferred from Partner to Amgen or vice versa. Unless and until determined otherwise by the JSC in accordance with the foregoing, the initial allocation of operational responsibility for development and regulatory activities for
each Product will be as set forth in the applicable Development Plan. 

  

	 	3.1.2.	 Development Lead. On a Product-by-Product basis, one Party will oversee development and regulatory activities for such Product in the
Collaboration 

  
 22 

	 	 
Scope (the “Development Lead”). The Development Lead for each Product is set forth in the Development/Commercial Lead Schedule. Absent agreement by the JSC to the contrary (as
indicated in the applicable Development Plan), it is the expectation of the Parties that the Development Lead will have primary responsibility for day-to-day development activities relating to the relevant Product, including generating protocols,
conducting clinical trials, and data collection, verification and analysis. Following the Effective Date, the Parties will promptly meet to coordinate the transition of development and regulatory activities from Amgen to Partner with respect to
Products for which Partner is the designated Development Lead in a manner so as to not unduly delay or hamper the development of the relevant Products. The Parties will amend the applicable Development Budgets and Operations Budgets to reflect the
reasonable costs to be incurred by each Party in connection with such transfer. 

  

	 	3.1.3.	 [*] Updates. The JSC will review and approve updates to the Development Plans and Development Budgets prior to [*].

  

	 	3.1.4.	 Conduct of Development. The Parties will cooperate in the conduct of the activities set forth in the applicable Development Plan, including
the preparation of protocols and the development of documents therefor. Both Parties will collaborate to achieve globally aligned regulatory documents and interactions for each Product. 

 

	 	3.1.5.	 Sharing of Materials. In the event that it becomes necessary for one Party to provide the other Party with tangible research or biological
materials (other than a Product for clinical or commercial use), the Parties will enter into an appropriate material transfer agreement related thereto, which agreement will be subject to this Agreement and will be interpreted consistent with the
terms hereof. 

  

	 	3.1.6.	 Ownership of Development and Safety Data. Each Party will solely own all data generated by it or its designee in its development activities
conducted hereunder, and such data will be subject to the license from Partner to Amgen under Section 10.5 (License Grant by Partner) or from Amgen to Partner under Section 10.4 (License Grant by Amgen), as applicable. Notwithstanding the
foregoing, the Development Lead will own the global safety database, the developmental core safety information (DCSI), and core data sheet for each Product. 

  
 23 

	3.2.	 Regulatory Matters.  

  

	 	3.2.1.	 Designated Regulatory Party. Except as set forth in Section 3.2.4 (Manufacturing Matters), the JSC will allocate, on a
Product-by-Product and country-specific basis, operational responsibility for regulatory activities to a Party (the “Designated Regulatory Party”) although there will be a presumption that the Development Lead will also be the
Designated Regulatory Party. 

  

	 	3.2.2.	 Regulatory Communications and Filings. The Designated Regulatory Party will prepare, submit and maintain all Regulatory Filings and obtain
all Regulatory Approvals for which it is responsible in accordance with the applicable Development Plan. The other Party will cooperate with the Designated Regulatory Party, at its reasonable request, with respect to any regulatory matters for which
the Designated Regulatory Party is responsible. Unless exigent action is required with respect to such Regulatory Filing or material communication, the Designated Regulatory Party will provide the other Party with copies of Key Regulatory Filings
prior to submission within a reasonable amount of time (but not less than five (5) business days) to allow such Party to review and comment on such Key Regulatory Filings, and the Designated Regulatory Party will consider all comments and
proposed revisions from the other Party in good faith prior to submission (but in the event of a disagreement between the Parties with respect to such comments and proposed revisions, (i) if the Development Lead’s determination is
consistent with the then-current Development Plan, then the Development Lead’s determination shall prevail, and (ii) if the Development Lead’s determination is not consistent with the then-current Development Plan, then such matter
shall be escalated to the JSC for review (and if a Critical Matter, further escalated to the CRC)). The Designated Regulatory Party will consult with the other Party regarding, and keep the other Party informed of, the status of the preparation of
all Regulatory Filings it submits, Governmental Authority review of any such Regulatory Filings, and all Regulatory Approvals that it obtains with respect to a Product. Upon request of the other Party, the Designated Regulatory Party will provide to
the other Party copies of all final Regulatory Filings it submits. 

  

	 	3.2.3.	 Regulatory Meetings. The Designated Regulatory Party will consult with the other Party reasonably in advance of the date of any anticipated
meeting with a Governmental Authority and will consider any timely recommendations made by the other Party in preparation for such meeting. Upon the request of the other Party, the Designated Regulatory Party will permit the other Party to attend
particular meetings between the Designated Regulatory Party and the applicable Governmental Authority. The Designated Regulatory Party will request that the applicable Governmental Authority allow at least one (1) representative of the other
Party to attend, solely as an observer, such meetings; provided, that the foregoing will not apply to informal meetings or unscheduled teleconferences or meetings or teleconferences otherwise intended by the Governmental Authority to be
between it and the Designated Regulatory Party’s 

  
 24 

	 	 
representatives only. The other Party will strictly follow the Designated Regulatory Party’s instructions with respect to any meeting which it attends, and will not discuss the contents of
any such meeting with any Governmental Authority except as required by Applicable Law or authorized by the Designated Regulatory Party in writing. 

  

	 	3.2.4.	 Manufacturing Matters. In order to assist the Designated Regulatory Party, the Manufacturing Lead will prepare [*] in English for the
relevant Product, and the Designated Regulatory Party will modify as appropriate such module for use in Regulatory Filings in the Collaboration Territory. The Manufacturing Lead will have the option, in order to protect proprietary manufacturing
information, to take over operational responsibility from the Designated Regulatory Party for some or all correspondence and for specified official communications, including the preparation and submission of all Regulatory Filings required to be
filed with any Governmental Authority in the Collaboration Territory with respect to the manufacture of a Product (except to the extent such transfer of operational responsibility is prohibited by Applicable Law or a Governmental Authority). With
respect to any such correspondence and communication, each Party will promptly provide the other with copies of material written correspondence as reasonably necessary to permit each Party to comply with its relevant regulatory obligations or as
otherwise reasonably requested; provided, that the Manufacturing Lead will not be required to disclose proprietary or competitively sensitive information unless such disclosure is required by Applicable Law. 

 

	 	3.2.5.	 Ownership of Regulatory Filings and Regulatory Approvals. The Development Lead for a Product will own all right, title and interest in and to
any and all Regulatory Filings and Regulatory Approvals directed to such Product and all such Regulatory Filings and Regulatory Approvals will be held in the name of the Development Lead, and the other Party will execute all documents and take all
actions as are reasonably requested by the Development Lead to vest such title in the Development Lead, subject to Section 3.1.6 (Ownership of Development and Safety Data) and Section 3.2.4 (Manufacturing Matters). The Development Lead
hereby grants to the other Party a non-exclusive, non-transferable (except in connection with a permitted assignment, sublicense or subcontract) “right of reference” (as defined in 21 C.F.R. §314.3(b)) with respect to such Regulatory
Filings and Regulatory Approvals solely as necessary for the other Party, if such other Party is the Designated Regulatory Party, to prepare, submit and maintain Regulatory Filings for which it is responsible or as otherwise necessary to perform its
obligations hereunder or to comply with Applicable Law. 

  

	3.3.	 Brand Security and Anti-Counterfeiting. The Parties will establish contacts for communication regarding brand security issues and will each
reasonably cooperate with the other with respect thereto. 

  
 25 

	3.4.	 Product Complaints, Recalls and Returns. The Parties’ rights and obligations with respect to nonconformance, recalls and returns of
Products will be governed by the applicable Quality Agreement. 

  

	3.5.	 Clinical Trial Register. The Development Lead will, in accordance with Applicable Law and its internal policies, publish the results or
summaries of clinical trials relating to a Product on a clinical trial register maintained by it and the protocols of clinical trials relating to such Product on www.ClinicalTrials.gov (or an equivalent register, or as otherwise required by
Applicable Law or such Party’s policies). The other Party will have the right to publish results or summaries (in the identical form as published by the Development Lead) if the Development Lead has already published in accordance with the
foregoing sentence, or the applicable JPT approves such publication. The Parties will cooperate to establish timelines and procedures for JPT review of publications and presentations. 

 

	3.6.	 Sharing of Data and Know-How. 

  

	 	3.6.1.	 Generally. Each Party shall (and shall cause its Affiliates to) reasonably cooperate with the other Party to promptly share and provide
access to (i) all clinical trial data and results within the Program Intellectual Property, and (ii) such other Know-How within the Product Intellectual Property as is reasonably necessary for the other Party to exercise its rights or
fulfill its obligations under this Agreement. The JSC may establish reasonable policies to effectuate such exchange of data and Know-How between the Parties. 

 

	 	3.6.2.	 Manufacturing Know-How. For clarity, except as provided in Section 3.2.4 (Manufacturing Matters) above, the Manufacturing Lead shall not
be obligated to share with the other Party or provide the other Party access to Know-How related to the manufacture of a Product unless and until such Party becomes the Manufacturing Lead with respect to such aspect of manufacturing of such Product,
in which case the Manufacturing Lead shall promptly provide the other Party with access to such manufacturing Know-How within the Product Intellectual Property as is reasonably necessary for such Party to fulfill its obligations as Manufacturing
Lead with respect to such Product. All such transfer of manufacturing Know-How shall be overseen and facilitated by the JPT for the applicable Product. 

 

	4.	MANUFACTURING 

  

	4.1.	 Allocation of Manufacturing Responsibility. Amgen will be responsible for the supply of clinical and commercial product for AMG827. Amgen
will be responsible for the initial supply of clinical product for all other Products (the “Early Stage Programs”). Amgen will elect at least [*] days prior to the initiation of the first [*] for each Early Stage Program whether or
not to continue supplying later stage clinical material and commercial material for such Early Stage Program itself or through a contract manufacturing organization. If Amgen elects not to do so, then Partner will have [*] days to elect to

  
 26 

	 	 
manufacture such later stage clinical material and commercial material for such Early Stage Program (including conducting any process development work related thereto). If neither Party elects to
manufacture later stage clinical material and commercial material for such Early Stage Program, then the Parties will mutually agree upon a Third Party manufacturer to conduct process development and clinical and commercial manufacturing. In any
event, Amgen will continue to supply clinical material (in the form that exists prior to such election) until such time as Partner or such Third Party manufacturer completes commercial process development and begins to supply such later stage
clinical material; provided, that, if Partner elects to manufacture later stage clinical material and commercial material, then Partner will promptly and diligently undertake such efforts as are necessary to assume responsibility for such
activities. 

  

	4.2.	 Manufacturing Lead. The Party that actually manufactures (itself or through a designee) a specific Product will be the “Manufacturing
Lead” for such manufactured Product. For clarity, one Party may be the Manufacturing Lead for drug substance and the other Party may be the Manufacturing Lead for drug product. Subject to Section 4.6 (Shortage; Allocation), the
Manufacturing Lead will use Commercially Reasonable Efforts to supply Product in a manner sufficient to fulfill demand for the Product in the Collaboration Territory. Additionally, if Partner elects to become the Manufacturing Lead for a Product in
accordance with Section 4.1 (Allocation of Manufacturing Responsibility) or is otherwise appointed the Manufacturing Lead by the CRC, the Parties will, with respect to Products manufactured by Partner, negotiate in good faith supplements to the
definitions of Manufacturing Standard Costs and Manufacturing Actual Costs in order to make such definitions consistent, on a GAAP or IFRS basis (as applicable), with the manner in which Partner accounts for its other products.

  

	4.3.	 [*] Updates. The JSC will review and approve updates to the Operations Budgets prior to [*]. Additionally, after Technical Feasibility has
been achieved with respect to a Product, on a quarterly basis the Manufacturing Lead will inform the JSC of any expected decrease in [*] that is expected to result in [*]. At the request of the other Party, the Manufacturing Lead will inform the
other Party of [*] and will discuss with the other Party [*] with respect thereto. The Manufacturing Lead will have the sole right to determine which of its manufacturing sites will be used to manufacture a Product and may transfer the manufacturing
of such Product from one site to another, so long as such transfer would not reasonably be likely to have a material adverse effect on the continued supply of such Product. 

 

	4.4.	 Distribution. Amgen will be solely responsible for the distribution of Products in the Amgen Distribution Countries. Partner will be solely
responsible for the distribution of Products in all other countries in the Collaboration Territory. The Party that actually distributes Products in a particular country will be deemed the “Distribution Party” for such country. The
Manufacturing Lead of drug product will supply Products for commercial use in labeled, finished form (unless otherwise agreed to by the JSC) to the other Party for distribution in the countries for which the non-Manufacturing Lead for drug product
has been allocated distribution responsibility. The non-Manufacturing Lead will reimburse the Manufacturing Lead for such Product at the Manufacturing Lead’s Manufacturing Actual Cost upon delivery

  
 27 

	 	 
of such Product to the non-Manufacturing Lead. Such reimbursement will not be included in the calculation of Collaboration Profit (Loss) under Section 7.2 (Profit/Expense Sharing), but
rather the non-Manufacturing Lead will be entitled to include such payment as part of Amgen Costs or Partner Costs, as applicable, upon sale of such Product to a Third Party. 

 

	4.5.	 Quality and Safety Agreements. Concurrently with the execution of this Agreement, the Parties have entered into the Quality Agreement with
respect to the supply of Products by Amgen to Partner for clinical use. Within ninety (90) days of the Effective Date, the Parties will enter into the Safety Agreement with respect to the supply of Products by Amgen to Partner for clinical use.
One year prior to the anticipated first commercial launch of a Product, the Parties will enter into a Quality Agreement with respect to the supply of Products by Amgen to Partner for commercial use and will work in good faith to revise the existing
Safety Agreement as necessary. In the event that Partner becomes a Manufacturing Lead for a Product, the Parties will enter into a Quality Agreement with respect thereto and will work in good faith to revise the existing Safety Agreement as
necessary. 

  

	4.6.	 Shortage; Allocation. In the event that the Manufacturing Lead reasonably believes that it will not be able to supply requirements for a
Product in accordance with a mutually agreed upon supply forecast, the Manufacturing Lead shall provide prompt written notice to the other Party thereof. If the Manufacturing Lead actually cannot supply a Product in accordance with such mutually
agreed upon supply requirements, then the Manufacturing Lead will undertake to allocate the manufacturing of Products with its other products so as to not [*]. For clarity, if the Manufacturing Lead cannot actually supply requirements for a Product
in accordance with a mutually agreed upon supply forecast, the Manufacturing Lead will reasonably allocate its manufacturing capacity over all its products in the following order of prioritization: (a) to [*]; (b) to [*]; (c) to [*];
and (d) to [*]. 

  

	5.	COMMERCIALIZATION 

  

	5.1.	 Allocation of Commercial Responsibility. The JSC will (i) allocate commercial activities to Amgen or Partner on a Product-by-Product
basis and country-specific or activity-specific basis, and (ii) determine whether operational responsibility for any such activity should be transferred from Partner to Amgen or vice versa. Allocations of commercial operational responsibility
for countries and regions may be set forth in country plans developed by the applicable JPT that are consistent with the allocation of responsibility established by the JSC and the Brand Plan, taking into account the planned launch timing for the
relevant country (as such plans may be updated or modified from time-to-time by the applicable JPT, the “Country Plans”). The initial allocation of commercial activities, as well as the guidelines for allocating commercial
activities in the future, is as set forth in the Commercial Allocation Schedule. 

  

	5.2.	 Commercial Lead. For each Product, one Party will oversee commercialization activities with respect to all indications for such Product in
the Collaboration Scope (the “Commercial Lead”). The Commercial Lead for each Product will be as set forth on the Development/Commercial Lead Schedule. 

  
 28 

	5.3.	 Initial Plans; [*] Updates. An initial Brand Plan for each Product will be approved by the JSC not later than three (3) months after
initiation of the first Phase 3 Trial for such Product; provided, that the initial Global Payer Plan and each initial Access and Pricing Plan will be approved by the JSC at such times as the JSC so determines. The JSC will review and approve
updates to the Brand Plans and Commercialization Budgets prior to [*]. 

  

	5.4.	 All Sales by Distribution Party. Only the Distribution Party with respect to a particular Product in a particular country is authorized to
sell such Product in such country. The Distribution Party will have the sole right, in such Party’s discretion, to take orders for and returns of, issue credits for, sell, and book sales for, such Product. The non-Distribution Party will
promptly forward to the Distribution Party all orders for, and requests to order, such Product. The Distribution Party will have the right to refuse or cancel any order for such Product without liability to the other Party. The non-Distribution
Party will not interfere with any agreement of the Distribution Party or any of its Affiliates related to such Product, including contracting for the sale of such Product. 

 

	5.5.	 Training. The JPT will establish a process by which the Parties will review, comment on and approve training materials and programs, and
training of the Parties’ sales forces for commercialization of the Products will be conducted using only training materials and programs approved in accordance with such process. Each Party will train its respective sales representatives with
respect to the promotion of a Product (and update such training from time to time as appropriate) which training will include compliance training as appropriate, all in accordance with the applicable Brand Plan. The Commercial Lead for a Product
will own all right, title and interest in the training materials developed hereunder for such Product (except with respect to any Housemarks of the other Party contained therein), and the non-Commercial Lead will execute all documents and take all
actions as are reasonably requested by the Commercial Lead to vest title to such training materials in the Commercial Lead. 

  

	5.6.	 Information Concerning Products. Each Party will ensure that no claims or representations in respect of a Product or the characteristics
thereof are made by or on behalf of it or its Affiliates (by sales force members or otherwise) that have not been approved by the JPT and neither Party will make any claim or representation that does not represent an accurate summary or explanation
of the labeling of such Product. 

  

	5.7.	 Promotional Materials. The JPT will establish a process by which the Parties will review, comment on and approve all written sales, promotion
and advertising materials relating to a Product, and other media and materials used to promote the Products or educate the public regarding an indication treated with a Product (collectively and including translations, “Promotional
Materials”). All Promotional Materials will be produced by the applicable Commercial Lead in accordance with the Brand Plan and such process and any use thereof by the non-Commercial Lead will be subject to prior approval of the Commercial
Lead. All Promotional Materials will include, to the extent permitted by Applicable Law, the Amgen Housemarks and the Partner Housemarks. Unless otherwise determined by the 

  
 29 

	 	 
applicable JPT, the Commercial Lead will be responsible for the printing and delivery to the other Party of Promotional Materials for use in such other Party’s Detailing obligations
hereunder. Other than a Party’s use and distribution of Promotional Materials that are approved in accordance with the foregoing process and used and distributed in connection with a Party’s Detailing of a Product, neither Party will
produce or modify (other than as concepts for consideration by the other Party), or distribute or otherwise use any Promotional Material relating to a Product. If so instructed by the applicable JPT, a Party will immediately cease to use any
Promotional Materials and will collect and destroy any such materials from its sales representatives (and record and document such collection and destruction (and provide a copy of such documentation to the other Party upon request)). The Commercial
Lead for a Product will own all right, title and interest in and to any and all Promotional Materials for such Product (except with respect to any Housemarks of the other Party included in any Promotional Materials), and the non-Commercial Lead will
execute all documents and take all actions as are reasonably requested by the Commercial Lead to vest title to such Promotional Materials in the Commercial Lead. 

 

	5.8.	 Detailing Reports and Audit Rights. 

  

	 	5.8.1.	Reporting. Each Party will provide the other Party with a report, in such form and manner as determined by the JSC, within forty-five (45) calendar days
after the end of each calendar month, setting forth the following information regarding the efforts of the reporting Party’s sales force in Detailing each Product during the preceding month: (i) the total number of Details made by such
sales force, including a breakdown of First Position Details, Second Position Details and Other Details by target and frequency of Detail by customer priority; and (ii) such other information as may be specified by the JSC. In any country in
the Collaboration Territory where the Parties are co-Detailing a Product, each Party will provide the foregoing information with respect to such Product [*]. In any country in the Collaboration Territory where the Parties are not co-Detailing a
Product, each Party will provide the foregoing information with respect to such Product [*]. 

  

	 	5.8.2.	 Audits. Each Party will keep complete and accurate records of its Detailing of Products in sufficient detail to permit the other Party to audit
its performance of Details hereunder. During regular business hours, with not less than ten (10) business days’ advance written notice and under reasonable obligations of confidentiality, a Party will permit the other Party or its
authorized representatives to: (i) have access to the records of Detailing activities maintained by such Party for purposes of verifying the accuracy of reports described in Section 5.8.1 (Reporting); and (ii) audit such records;
provided, that such audits may not be performed by a Party more than once per calendar year, such records will be open (in such form as may be available or reasonably requested) to inspection for at least three (3) years following the
end of the period to which they pertain, and such records for any particular calendar year will only be subject to one (1) audit. Any and all audits undertaken pursuant to this Section 5.8.2 (Audits) will be performed at the sole and
exclusive expense 

  
 30 

	 	 
of the auditing Party and will not be included in Amgen Costs or Partner Costs, as the case may be, for purposes of calculating Collaboration Profit (Loss). If an audit reveals an overstatement
of Details of greater than [*] of the correct amount for the audited period, then the audited Party will pay the reasonable out-of-pocket cost of such inspection. 

 

	5.9.	 Competing Products. If either Party or its Affiliates has sales representatives Detailing both a Product and a non-Product that is approved
by a Governmental Authority for use in the same indication as such Product (a “Competing Product”), then, in addition to the reporting obligations contained in Section 5.8.1 (Reporting), such Party will provide to specified
employees of the other Party (as specified by such Party’s JSC members) with a report within thirty (30) calendar days after the end of each calendar month, setting forth [*]. The purpose of such report shall be solely to substantiate the
calculation of Sales Force Costs. It shall only be used by the specified employees and it shall not be used by either Party in violation of any Applicable Law. If the JSC or CRC authorizes a sales representative to Detail a Product in the First
Position Detail, then [*]. 

  

	5.10.	 Sales Force [*]. On a country-by-country and Product-by-Product basis, during the period of time beginning [*] of such Product in such
country, if either Party intends to [*] in such country that are expected to [*] such Product, then such Party shall provide the other Party with at least sixty (60) days’ prior written notice. In such event, at the request of either
Party, the JSC shall meet to [*] in such country (with escalation to the CRC if the JSC is unable to agree on such [*]). The Party that has [*] during the applicable period (but not to exceed [*] that are in excess of its [*].

  
 31 

	6.	PERFORMANCE STANDARDS 

  

	6.1.	 Collaborative Activities. Activities to be undertaken by the Parties hereunder will be conducted in a collaborative manner as determined by
the committee or team overseeing such activities, and in accordance with the terms and conditions of this Agreement, as applicable. 

  

	6.2.	 Diligence and Performance Standards. Subject to the decisions made by and oversight of the committees and teams established hereunder, each
Party will use, and will assure that each of its Affiliates uses, Commercially Reasonable Efforts in the performance of its and their activities hereunder. Each Party will conduct, and ensure that each of its Affiliates conducts, all of its and
their activities with respect to the development, registration, manufacture, distribution, promotion and commercialization of a Product in accordance with this Agreement, the applicable Development Plan, the applicable Brand Plan, applicable Global
Payer Plan, applicable Access and Pricing Plan, applicable Country Plans, accepted national and international pharmaceutical industry codes of practices in and for the Collaboration Territory (including the Pharmaceutical Research and Manufacturers
of America (PhRMA) Code of Pharmaceutical Marketing Practices and the American Medical Association (AMA) Guidelines on Gifts to Physicians from Industry, as the same may be amended from time to time), and all Applicable Law. The Parties will provide
each other with all reasonably requested cooperation to enable each of them to comply with Applicable Law and accepted national and international pharmaceutical industry standards, including permitting each Party to verify the other Party’s
compliance therewith. 

  

	6.3.	 Violation of Laws. Each Party will promptly notify the other Party of any violation of Applicable Law by its personnel with respect to
the conduct of activities under this Agreement. In the event of any such violation, the Parties will promptly confer regarding any such violation and will promptly take remedial or preventative action as may be reasonably required by the applicable
JPT with respect thereto. The Parties will have the right to require that any personnel that materially violates Applicable Law or applicable national or international pharmaceutical industry codes of practices cease to perform activities under this
Agreement. 

  

	6.4.	 Use of Affiliates and Third Party Contractors. Each Party will perform the activities designated to it itself or through any of its
Affiliates, and any proposed use of a Third Party to conduct such activities will be subject to the other Party’s prior written consent, such consent not to be unreasonably withheld; provided, that (i) Partner’s consent will
not be required for activities Amgen has, prior to the Effective Date, arranged to have performed by Third Parties and which have been disclosed to Partner prior to the Effective Date, and (ii) either Party will be permitted to, upon thirty
(30) days’ prior written notice to the other Party, engage a Third Party contract manufacturer, contract research organization, contract sales organization, distributor or wholesaler without the other Party’s consent. Cost overruns
resulting from either Party’s use of a Third Party to conduct any such activities will be subject to Section 7.2.6 (Overruns). Each Party will be responsible for compliance by its respective Affiliates and Third Party

  
 32 

	 	 
contractors with this Agreement and will be responsible for all acts and omissions of such Affiliates and Third Party contractors as if committed or omitted by the applicable Party.

  

	6.5.	 Management of Personnel. Each Party will have sole authority and responsibility for recruiting, hiring, managing, compensating (including
paying for all benefits, wages, special incentives, workers’ compensation and employment taxes), disciplining, firing and otherwise controlling the personnel provided by such Party for performance of its obligations hereunder; provided,
that each Party will require its personnel to be subject to a confidentiality agreement and Invention assignment commitment prior to, and as a condition of, such personnel performing any such activities hereunder. Each Party will provide the
day-to-day management of its sales representatives and other personnel, including furnishing administrative support, financial resources, equipment and supplies. 

 

	7.	 UP-FRONT PAYMENT AND PROFIT/EXPENSE SHARING 

 

	7.1.	 Up-front Payment. As partial consideration for the rights granted to Partner by Amgen pursuant to the terms of this Agreement, Partner will
pay to Amgen a non-refundable, non-creditable payment equal to Fifty Million Dollars ($50,000,000.00) within fifteen (15) days after the Effective Date, payable by wire transfer of immediately available funds in accordance with wire transfer
instructions of Amgen that will be provided in writing to Partner prior to the Effective Date. 

  

	7.2.	 Profit/Expense Sharing. The Parties will share in profits and losses generated by Products in the Collaboration Scope as follows:

  

	 	7.2.1.	 Partner Costs. Within forty-five (45) days after the end of each calendar quarter Partner will provide to Amgen a detailed, itemized
report of its Development Costs and General Costs, on a Product-by-Product basis, incurred by Partner or its Affiliates in accordance with this Agreement (collectively, “Partner Costs”) in such quarter in the format set forth in the
Invoice Schedule attached hereto. In addition to the annual JSC approval of the relevant budgets for each Product, prior to the end of each calendar year, Partner will provide Amgen with a non-binding estimate of its Development Costs and General
Costs for each Product for the [*] period (detailed on a calendar year basis) following the [*] covered by such approved budget; provided, that the Parties will review and discuss such estimated costs at the JSC. 

 

	 	7.2.2.	 Amgen Costs. Within forty-five (45) days after the end of each calendar quarter Amgen will provide to Partner a detailed, itemized
report of its Development Costs and General Costs, on a Product-by-Product basis, incurred by Amgen or its Affiliates in accordance with this Agreement (collectively, “Amgen Costs”) in such quarter in the format set forth in the
Invoice Schedule attached hereto. In addition to the annual JSC approval of the relevant budgets for each Product, prior to the end of each calendar year, Amgen will provide Partner with a
non-

  
 33 

	 	 
binding estimate of its Development Costs and General Costs for each Product for the [*] period (detailed on a calendar year basis) following the [*] covered by such approved budget;
provided, that the Parties will review and discuss such estimated costs at the JSC. For clarity, any costs incurred by or on behalf of Amgen in connection with the research and development of AMG557 for the sole benefit of Japan or the
research and development of AMG827 for the sole benefit of the applicable Excluded Territory will not be included in Amgen Costs. 

  

	 	7.2.3.	 FTE Rate. The FTE Rate used for calculation of Costs pursuant to this Article 7 (Profit/Expense Sharing) with respect to any activity will be
the relevant FTE Rate for the calendar year in which such activity was undertaken. 

  

	 	7.2.4.	 Income Taxes. For the avoidance of doubt, income and withholding taxes imposed on either of the Parties hereunder will not be included in
cost sharing hereunder. 

  

	 	7.2.5.	 Exchange Rate. For purposes of calculating quarterly balancing payments as set forth in Section 7.2.9 (True-Up), Net Revenues, Amgen
Costs and Partner Costs will be converted from local currency (if different from U.S. Dollars) to U.S. Dollars in accordance with Section 8.3.2 (Conversions). 

 

	 	7.2.6.	 Overruns. Each Party will promptly notify the other Party upon becoming aware that the anticipated Costs to be incurred by such Party for a
given calendar year will be in excess of the applicable Development Budget, Operations Budget or Commercialization Budget. Unless otherwise agreed by the Parties in advance, in writing, Costs reported by a Party pursuant to Section 7.2.1
(Partner Costs) or 7.2.2 (Amgen Costs) incurred with respect to a Product in excess of [*] percent ([*]%) of the aggregate amounts budgeted to be incurred by or on behalf of such Party for its activities for such Product in such calendar year in the
then-current applicable Development Budget, Operations Budget or Commercialization Budget, respectively, will not be included in the calculation of profit (or loss) pursuant to Section 7.2.8 (Calculation of Profit (or Loss)); provided,
that such Partner Costs and Amgen Costs in excess of such amount will be included in the calculation of profit (or loss) pursuant to Section 7.2.8 (Calculation of Profit (or Loss)) (A) to the extent such Costs were attributable to:
(i) a change in Applicable Law; (ii) a Force Majeure event; [*]. 

  

	 	7.2.7.	 Net Revenues. Within five (5) business days prior to the end of each calendar quarter, each Party will provide the other Party with a
reasonably detailed estimate of Net Revenues for such calendar quarter in the countries for which it is the Distribution Party. Within thirty (30) days after the end of each calendar quarter, each Party will provide the other Party with a
report of Net Revenues for such calendar quarter in the countries for which it is the Distribution Party, which report will contain a detailed and itemized calculation of Net Revenues for each Product in such countries during such calendar quarter.

  

	 	7.2.8.	 Calculation of Profit (or Loss). 

  

	 	7.2.8.1.	 Costs.  

  
 34 

	 	7.2.8.1.1.	 Allocation. On a calendar quarter-by-calendar quarter basis, Partner will be responsible for one hundred percent (100%) of the following
cost items, in the order set forth below, up to the Quarterly Cap for such calendar quarter. Thereafter, Amgen shall be responsible for one hundred percent (100%) of such costs for such calendar quarter. 

 

	 	7.2.8.1.1.1.	         Unreimbursed Development Costs and General Costs. First, Partner will be responsible for one
hundred percent (100%) of Unreimbursed Development Costs and General Costs up to the Quarterly Cap. 

  

	 	7.2.8.1.1.2.	         Reimbursed Development Costs. If, following reimbursement for Unreimbursed Development Costs
and General Costs, the Quarterly Cap has not yet been met, then Partner will be responsible for one hundred percent (100%) of Reimbursed Development Costs up to the Quarterly Cap. 

 

	 	7.2.8.1.2.	     Quarterly Cap. The “Quarterly Cap” for a given calendar quarter shall, during the applicable
calendar year set forth below, be as follows: 

  

					
		 	  

Calendar Year

 
	 	  

Quarterly Cap

 

		 	  
 2012
  
	 	  

65% of Total Costs for the applicable calendar
 quarter - [*]
  

		 	  
 2013
  
	 	  

65% of Total Costs for the applicable calendar
 quarter + [*]
  

		 	  
 2014
  
	 	  

65% of Total Costs for the applicable calendar
 quarter
  

		 	  
 2015 and each year thereafter
  
	 	  

50% of Total Costs for the applicable calendar
 quarter
  

 The Development Costs and General Costs for any calendar quarter will only include [*]
of Development Costs and General Costs incurred in the conduct of the [*] set forth in the Development Plan for [*]. In the event either (i) the designated endpoints set forth on the [*] Designated Endpoints [*] Schedule for the [*] are met, or
(ii) the Parties agree to initiate a [*], then Amgen shall have the right to allocate an amount equal to [*] of the Development Costs and General Costs incurred after the Effective Date in the conduct of the [*] between: (a) a one-time
success milestone payment from Partner to Amgen (payable within forty-five (45) days of notice from Amgen of the allocation between (a) and (b) provided below) and (b) an immediate increase (applied evenly) to the Quarterly Cap
for the subsequent four (4) calendar quarters. Amgen shall notify Partner in writing as to the allocation, which must total one hundred percent 

  
 35 

 
(100%) between (a) and (b). Additionally as of the Effective Date, the Parties agree that the [*] set forth in the Development Plan for [*] is optional for the [*]. The Parties will evaluate
whether or not it is beneficial to conduct the [*] as part of such trial. If the Parties disagree, then Amgen shall have the right, [*], to conduct the [*].) If the [*] meets the designated endpoints set forth on the [*], then Partner will reimburse
Amgen [*] of the Costs associated with the [*] (to be allocated between a milestone or increase to the Quarterly Cap as set forth in the forgoing sentence at Amgen’s option) and any Costs associated with the [*] incurred after such endpoints
have been met will be included in Amgen Costs and shared in accordance with Section 7.2.8.1 (Costs). 
  

	 	7.2.8.2.	         Profit. The total profit for a calendar quarter will be calculated by Amgen by first
deducting from aggregate Net Revenues for each Product for such quarter a percentage of such Net Revenues equal to the applicable “Inventorship Margin” set forth below, which will be paid to Amgen to reflect Amgen’s inventorship of
the Products: 

  

							
		 	  

Inventorship Margin

 
	  	
		 	  
 AMG827
  
	 	  
 Other Products    
  
	  	
		 	  
 [*]
  
	 	  
 [*]
  
	  	

 Additionally, [*]. After deduction of the Inventorship Margin [*], the remaining Net
Revenues will be shared by the Parties equally. 
  

	 	7.2.9.	 True-up. Within sixty (60) days after the end of each calendar quarter, Amgen will calculate and provide to Partner a report of the
amount each Party is responsible for under Section 7.2.8.1 (Costs) for such quarter, and a report of the amount each Party is entitled to under Section 7.2.8.2 (Profit). The resulting amounts under Sections 7.2.8.1 (Costs) and 7.2.8.2
(Profit) will be the “Collaboration Profit (Loss)” for such calendar quarter. A balancing payment will be made between the Parties in order to effect the profit and loss sharing allocation set forth in Section 7.2.8
(Calculation of Profit (or Loss)). The net paying Party will make a payment pursuant to this Section 7.2.9 (True-up) within thirty (30) days after delivery of such report of Collaboration Profit (Loss). 

 

	 	7.2.10.	 Payments. Payments pursuant to this Article 7 (Profit/Expense Sharing) will be made in accordance with the provisions of Article 8
(Payments). 

  

	 	7.2.11.	 Calculation of Sales Force Costs. Sales force FTE costs for each of the Parties will be determined by including in Partner Costs or Amgen
Costs, as the case may be, a pro rata portion of each Party’s sales representative’s FTE Rate as 

  
 36 

	 	 
follows: (i) [*] if such sales representative Details only a single Product (and no other products) with the approval of the CRC; (ii) [*] if such sales representative Details two
(2) products with a Product as the First Position Detail or Details only a Product without the approval of the CRC; (iii) [*] if such sales representative Details three (3) or more products with a Product as the First Position Detail;
(iv) [*] if such sales representative Details two (2) products with a Product as the Second Position Detail; (v) [*] if such sales representative Details three (3) or more products with a Product as the Second Position Detail;
and (vi) [*] if such sales representative Details three (3) or more products with a Product as the Other Detail. If a sales representative Details more than one (1) Product, then the foregoing percentages will be aggregated for each
such Product. For the avoidance of doubt, if a sales representative Details a Product in more than one (1) position, then a pro rata share of the foregoing percentages, to be calculated based on the time spent by such sales representative on
Detailing such Product in each such position, will be included in Partner Costs or Amgen Costs, as the case may be. For periods in which sales representatives are performing activities in support of the collaboration but are not Detailing Products
(e.g., during launch preparation or training), FTE costs will be calculated based upon percent of effort, resource utilization or other reasonable measure, in each case calculated and allocated in accordance with the applicable Party’s
accounting procedures, consistently applied. 

  

	 	7.2.12.	 Kirin-Amgen and Takeda Payments. For clarity, the Parties agree and acknowledge that any payments received by Amgen from (i) in the case
of AMG827, Kirin-Amgen, Inc. or Kyowa Hakko Kirin Co., Ltd and (ii) in the case of AMG557, Takeda Pharmaceutical Company Limited, in each case pursuant to the related Excluded Territory Agreement with such Third Party, shall be excluded from
the calculation of Collaboration Profit (Loss). Any such payments shall not, in any way (in part or in full), reduce Amgen Costs hereunder, and Amgen shall be entitled to retain any such payments in full without compensation to, or any separate
accounting or audit right undertaken by, Partner. 

  

	7.3.	 Example. The Profit (Loss) Example Schedule sets forth an example of calculation and true-up of the Collaboration Profit (Loss).

  

	7.4.	 Calculation of Net Revenues. In calculating Net Revenues for the purposes of this Article 7 (Profit/Expense Sharing):

  

	 	7.4.1.	 Free Products. Any disposal of a Product at no charge for, or use of a Product without charge in, clinical or pre-clinical trials, given as
free samples, or distributed at no charge to patients unable to purchase the same will not be included in Net Revenues. 

  

	 	7.4.2.	 Bundled Products. Where a Product is sold in a Bundle, then for the purposes of calculating Net Revenues under this Agreement, such Product
will be deemed to be sold for an amount equal to [X ÷ (X + Y)] × Z, where: X is the average sales price during the applicable reporting period generally achieved for such dosage form of such Product in the Collaboration Scope; Y is the
sum of 

  
 37 

	 	 
the average sales price during the applicable reporting period generally achieved in the Collaboration Territory, when sold alone, by each pharmaceutical product in the relevant dosage form
included in the Bundle (excluding such Product); and Z equals the price at which the Bundle was actually sold. In the event that such Product or one or more of the other pharmaceutical products in the Bundle are not sold separately in the relevant
dosage form, Net Revenues from the sale of such Bundle will be reasonably allocated between such Product and the other product(s) in such Bundle based upon their relative values and the Parties will determine the equitable fair market prices to
apply to such Bundle; provided, that in the event of a disagreement with respect to such relative values, the Parties will engage a mutually agreed upon independent expert to make the final determination with respect thereto. Notwithstanding
the foregoing, no Product will be sold in a Bundle if such sale would violate Applicable Law. 

  

	7.5.	 Excluded Losses. The following losses will not be charged to the Collaboration Profit (Loss): (i) losses of a Party to the extent
attributable to a breach of this Agreement by such Party, or (ii) losses subject to indemnification pursuant to Section 13.1 (Indemnity by Partner) or Section 13.2 (Indemnity by Amgen). 

  
 38 

	7.6.	 Manufacturing Costs Calculation and True-Up. Manufacturing Standard Costs for a Product, calculated as part of Development Costs, will be
included in Amgen Costs and Partner Costs, as applicable, at the time of manufacture of such Product. Prior to Technical Feasibility, Manufacturing Actual Costs for a Product intended for use in a clinical trial, calculated as part of Development
Costs, will be included in Amgen Costs and Partner Costs, as applicable, at the time of manufacture of such Product. After Technical Feasibility, Manufacturing Actual Costs for a Product intended for use in a clinical trial, calculated as part of
Development Costs, will be included in Amgen Costs and Partner Costs, as applicable, at the time such Product is shipped to a site for use of such Product in a clinical trial. Subject to Section 4.4 (Distribution), Manufacturing Actual Costs
for a Product for commercial use, calculated as part of General Costs, will be included in Amgen Costs and Partner Costs, as applicable, at the time of sale of such Product. In addition, due to the fact that Manufacturing Actual Costs may not be
known at the time such costs are to be included within the Collaboration Profit (Loss), for the purposes of determining Development Costs or General Costs for a particular calendar quarter, the Manufacturing Lead will, to the extent any
manufacturing costs are to be calculated using Manufacturing Actual Costs, use the then-current estimated Manufacturing Actual Costs for such calendar quarter. By March 31 of each calendar year, the Manufacturing Lead will reconcile the
estimated Manufacturing Actual Costs included in Development Costs and General Costs in the prior calendar year with the final Manufacturing Actual Costs for such Product and provide such reconciliation to the other Party. If such reconciliation
leads to an over or under payment by either Party, a balancing payment will be made between the Parties in order to maintain the intended profit and loss sharing allocation set forth in this Agreement within thirty (30) days after delivery of
such reconciliation report by the Manufacturing Lead and agreement thereon by the Parties. 

  

	7.7.	 Budget Deadlocks. In the event that the JSC is unable to approve [*] Development Budget, Operations Budget or Commercialization Budget prior
to the expiration of any such budget, then, until approval of such budget by the CRC, each Party will be entitled to continue the Designated Amgen Activities and Designated Partner Activities, as applicable, and include its Development Costs and
General Costs, as applicable, in the calculation of Collaboration Profit (Loss) for any calendar quarter not covered by an approved budget, until such time as the aggregate Development Costs and General Costs of such Party included in the
calculation of Collaboration Profit (Loss) for [*] equal the amount of such Party’s Development Costs and General Costs included in the then most recent estimate provided under Sections 7.2.1 (Partner Costs) and 7.2.2 (Amgen Costs), as
applicable, plus [*] of such estimate. 

  

	7.8.	 Program Recommitment. [*], after the applicable Continued Development Meeting for a Product has been held and upon consultation at the CRC,
in the event either (or both) Party(ies) do not wish to continue to participate in the continued development and commercialization of such Product, each Party will have the right to suspend its participation by providing the other Party with a
written notice thereof on or prior to [*] days following the applicable Continued Development Meeting. A Party so suspending its commitment will be referred to as a 

  
 39 

	 	 
“Suspending Party” and a Party not doing so a “Non-Suspending Party”. 

 

	 	7.8.1.	 Suspension. 

  

	 	7.8.1.1.	 Suspension Election. If only one Party delivers a notice of suspension with respect to a Product (a “Suspension Election”),
then the remaining provisions of this Section 7.8 (Program Recommitment) shall apply. If both Parties deliver a notice of suspension with respect to a Product, then the Agreement shall be deemed to be terminated with respect to such Product in
accordance with Section 14.2 (Termination for Convenience) and Section 14.6.1 (Product by Product Termination) and Amgen shall be the Continuing Party with respect to such Product. 

 

	 	7.8.1.2.	 Transition. Upon making a Suspension Election, the Suspending Party will, at the Non-Suspending Party’s cost, undertake all reasonable
efforts to effect a smooth and orderly transition of its development, regulatory and commercial activities and responsibilities under this Agreement with respect to such Product to the Non-Suspending Party. If the Suspending Party is the
Manufacturing Lead for such Product, then, at the Non-Suspending Party’s cost, the Suspending Party will use all reasonable efforts to continue to supply Product for clinical use and complete any commercial process development activities
initiated prior to the effective date of such Suspension Election; provided, that, the Manufacturing Lead will have the right to transition such manufacturing to a contract manufacturer or, if agreed to by the Non-Suspending Party, to the
Non-Suspending Party. For clarity, from and after the effective date of any Suspension Notice, the Suspending Party shall not be liable for any Development Costs or General Costs for such Product committed before the effective date of the Suspension
Notice but not yet incurred at that date or otherwise incurred after such date. 

  

	 	7.8.1.3.	 Committee Participation. Upon making a Suspension Election and until such time as the Suspending Party elects to resume funding its share of
Development Costs and General Costs with respect to such Product pursuant to Section 7.8.2 (Re-Entry Right) below, the Suspending Party’s right to participate on the CRC, the JSC, any JPT and any subcommittee or subteam thereunder will be
limited to a right to participate in any meetings brought before such committee or team without any right to vote on any matter that specifically relates to such Product (for clarity the Suspending Party will retain the right to vote on any matter
that relates to any other Product). Additionally, if the Suspending Party was the Development Lead and Commercial Lead for such Product, then the Non-Suspending Party shall be the Development Lead and Commercial Lead going forth, and the Suspending
Party shall not be entitled to resume such role even if such Party elects to resume funding its share of Development Costs and General Costs with respect to such Product pursuant to Section 7.8.2 (Re-Entry Right) below. Additionally, the
Non-Suspending Party shall promptly share with, and provide access to, the Suspending Party (i) all clinical trial data and results within the 

  
 40 

	 	 
Program Intellectual Property, (ii) such other Know-How within the Product Intellectual Property generated before the date of the Suspension Election; and (iii) any other information
reasonably requested by the Suspending Party related to such Product. 

  

	 	7.8.1.4.	 Subsequent Termination. If the Non-Suspending Party subsequently decides that it is no longer willing to continue further development and
commercialization of the Product, then the Non-Suspending Party may elect to terminate further development and commercialization by providing the Suspending Party with [*] prior written notice (a “Termination Election”). If the
Suspending Party is Partner and Amgen delivers a Termination Election during the Re-Entry Period, then upon receipt of such Termination Election from Amgen, Partner shall have the right upon prior written notice, delivered by no later than [*]
following receipt of Amgen’s Termination Election, to elect to continue with the further development and commercialization of the Product, in which case, Partner shall thereafter be deemed to be the Non-Suspending Party and Amgen shall be
deemed to be the Suspending Party. If Partner does not elect within such [*] period to continue with such development or commercialization or if Partner is the Non-Suspending Party, then upon the effective date of a Termination Election, the
Agreement shall be deemed to be terminated with respect to such Product in accordance with Section 14.2 (Termination for Convenience) and Section 14.6.1 (Product by Product Termination) and Amgen shall be the Continuing Party with respect
to such Product. 

  

	 	7.8.2.	 Re-Entry Rights. 

  

	 	7.8.2.1.	 Re-Entry Period. With respect to any non-terminated Product subject to a Suspension Election, at any time beginning upon receipt of the
Suspension Election until [*] following the receipt of the flash memo for the applicable Stage 2 Clinical Trial for such Product and receipt of any information requested by the Suspending Party that is reasonably necessary to determine whether to
re-enter the program (the “Re-Entry Period”), the Suspending Party will have the right to re-enter the program by written notice (a “Re-Entry Notice”) to the Non-Suspending Party, effective as of the date of receipt
of such notice by the Non-Suspending Party. 

  

	 	7.8.2.2.	 Re-Entry Payment. In the event of such re-entry, the Suspending Party will pay the Non-Suspending Party an amount equal to [*].

  

	 	7.8.2.3.	 Lapse. If the Suspending Party fails to provide the Re-Entry Notice with respect to a Product during the applicable Re-Entry Period, then the
Suspending Party shall be deemed to have terminated the Agreement with respect to such Product in accordance with Section 14.2 (Termination for Convenience) and Section 14.6.1 (Product by Product Termination). 

 

	 	7.8.2.4.	 Out-license. If, during the Re-Entry Period for a Product, the
Non-

  
 41 

	 	 
Suspending Party elects to grant to a bona fide Third Party the exclusive right to develop or commercialize such Product in any country within the Collaboration Territory, then the Non-Suspending
Party will provide the Suspending Party with [*] prior written notice (the “Out-License Election”). If the Suspending Party fails to provide a Re-Entry Notice within [*] of receipt of the Out-License Election and the Out-License Election
relates to only certain countries within the Collaboration Territory, then the Suspending Party’s right to re-enter the program shall exclude such countries. If the Suspending Party fails to provide a Re-Entry Notice within [*] of receipt of
the Out-License Election and the Out-License Election relates to all countries within the Collaboration Territory, then, then the Suspending Party’s right to provide a Re-Entry Notice with respect to such Product shall terminate.

 8. PAYMENTS 
  

	8.1.	 Appropriate Measure of Value. Each of the Parties acknowledges that the value provided by the other hereunder is comprised of many
related items, including performance of various services, access to development, regulatory, manufacturing and commercial expertise, clinical data and other financial and non-financial consideration and that the amount of the Inventorship Margin,
and the ratio of profit and expense sharing set forth herein are intended to capture such value as an aggregate. Therefore, the increase, decrease or lapse of any particular items or rights (including Patents), including allocation of operational
responsibilities between the Parties, will not affect the amount of such payment, or the ratio of profit and expense sharing and the Parties agree that both the amount and duration of such payment and the ratio of profit and expense sharing are
reasonable. 

  

	8.2.	 No Other Compensation. Other than as explicitly set forth in this Agreement, neither Party will be obligated to pay any additional fees,
milestone payments, royalties or other payments of any kind to the other hereunder. 

  

	8.3.	 Currency. 

  

	 	8.3.1.	 Payments. All payments made hereunder between the Parties will be made in U.S. Dollars except as set forth in Section 8.5 (Blocked
Currency) or as otherwise agreed by the Parties. Each Party will pay all sums due hereunder by wire transfer, or electronic funds transfer (EFT) in immediately available funds. If the EFT option is chosen by Amgen or Partner, a completed electronic
funds transfer form will be provided in a timeframe that facilitates timely payment. Each Party will promptly notify the other Party of the appropriate account information to facilitate any such payments. All amounts set forth in any budget
established under this Agreement will be expressed in U.S. Dollars except as otherwise agreed by the Parties. 

  

	 	8.3.2.	 Conversions. With respect to amounts required to be converted into another currency for calculation or payment, hereunder, such amounts will
be converted using a rate of exchange which corresponds to the rate used for conversion 

  
 42 

	 	 
between the relative currencies by whichever Party recorded the relevant receipt or expenditure, for the respective reporting period in its books and records that are maintained in accordance
with GAAP or IFRS, as the case may be. If a Party is not required to perform such a currency conversion for its GAAP or IFRS reporting with respect to the applicable period, then for such period such Party will make such conversion using the rate of
exchange which corresponds to the noon buying rate as published in the Wall Street Journal, Eastern U.S. Edition on the second to last business day of the calendar quarter (or such other publication as agreed-upon by the Parties) in which
such receipt or expenditure was incurred. 

  

	8.4.	 Audits. Each Party will keep complete and accurate records pertaining to the activities to be conducted hereunder in sufficient detail to
permit the other Party (the “Auditing Party”) to confirm the accuracy of all payments due hereunder, and such records will be open (in such form as may be available or reasonably requested) to inspection for [*] following the end of
the period to which they pertain. The Auditing Party will have the right, at its own expense to have an independent, certified public accountant, selected by it, perform a review of the records of the other Party (the “Audited
Party”) applicable to amounts payable hereunder (including any records kept in the ordinary course of the Audited Party’s business) during regular business hours, with not less than ten (10) business days’ advance written
notice and under reasonable obligations of confidentiality. The report of such accountant will be made available to both Parties simultaneously, promptly upon its completion. The Auditing Party’s right to perform an audit pertaining to any
calendar year will expire [*] after the end of such year and the books and records for any particular calendar year will only be subject to one (1) audit. Should an inspection pursuant to this Section 8.4 (Audits) lead to the discovery of
a payment discrepancy, then the appropriate Party will pay to the other the amount of the discrepancy (plus, if the error was in favor of the Auditing Party, interest accrued at the Contract Interest Rate, compounded annually from the day the
relevant payment(s) were due). If a payment discrepancy was greater than [*] of the correct amount for the audited period and the discrepancy was in favor of the Audited Party, then the Audited Party will pay the reasonable out-of-pocket cost of
such inspection, but in no case will the costs of an audit pursuant to this Section 8.4 (Audits) be included in Partner Costs or Amgen Costs or otherwise included in the calculation of Collaboration Profit (Loss). This Section 8.4 (Audits)
does not apply to or include manufacturing audits or regulatory inspections. 

  

	8.5.	 Blocked Currency. If Applicable Law in the Collaboration Territory prevents the prompt remittance of any payments with respect to sales
therein, the paying Party will have the right and option to make such payments by depositing the amount thereof in local currency to the other Party’s account in a bank or depository in such country. 

 

	8.6.	 Taxes. 

  

	 	8.6.1.	 Withholding. If Applicable Law requires a Party to pay or withhold Taxes with respect to any payment to be made pursuant to this Agreement,
the paying Party will notify the other in writing of such payment or withholding requirements prior to making the payment and provide such assistance to the receiving Party, 

  
 43 

	 	 
including the provision of such documentation as may be required by a tax authority, as may be reasonably necessary in such Party’s efforts to claim an exemption from or reduction of such
Taxes. Each Party will withhold any Taxes required by law to be withheld from the amount due, remit such Taxes to the appropriate tax authority, and furnish the other Party with proof of payment of such Taxes promptly following payment thereof. If
Taxes are paid to a tax authority, each Party will provide the other such assistance as is reasonably required to obtain a refund of Taxes withheld, or obtain a credit with respect to Taxes paid. In the event that the governing tax authority
retroactively determines that a payment made by a Party to the other pursuant to this Agreement should have been subject to withholding (or to additional withholding) for Taxes, and such Party (the “Withholding Party”) remits such
withholding Taxes to the tax authority, the Withholding Party will have the right to offset such amount, including any interest and penalties that may be imposed thereon (except to the extent any such interest or penalties result from the negligence
of the Withholding Party), against future payment obligations of the Withholding Party under this Agreement (or, at the option of the Withholding Party, the Withholding Party will have the right to invoice the other Party for such amount, and the
other Party will pay such amount within sixty (60) days of the receipt of such invoice); provided, that the Withholding Party may also pursue reimbursement by any other available remedy. 

 

	 	8.6.2.	 Indirect Taxes. All payments are exclusive of Indirect Taxes. If any Indirect Taxes are chargeable in respect of any payments, the paying
Party shall pay such Indirect Taxes at the applicable rate in respect of such payments following receipt, where applicable, of an Indirect Taxes invoice in the appropriate form issued by the receiving Party in respect of those payments. The Parties
shall issue invoices for all amounts payable under this Agreement consistent with Indirect Tax requirements and irrespective of whether the sums may be netted for settlement purposes. If such amounts of Indirect Taxes are refunded by the applicable
Governmental Authority or other fiscal authority subsequent to payment, the Party receiving such refund will transfer such amount to the paying Party within forty-five (45) days of receipt. 

 

	 	8.6.3.	 Employee Taxes. Each Party shall be responsible for taxes based on, imposed on or calculated by reference to any employees employed by that
Party. 

  

	 	8.6.4.	 Imports. For the avoidance of doubt, the Parties acknowledge and agree that none of the upfront payment or royalties payable under this
Agreement are related to the license (or right) to import or any import of Products. The Parties shall cooperate in accordance with Applicable Laws to ensure where permissible no import duties are paid on imported Product. The Parties
shall cooperate to ensure that the Party responsible for shipping values clinical Product in accordance with Applicable Laws and minimises where permissible any such duties and any related import taxes that are not reclaimable from the relevant
authorities. The receiving Party shall be responsible for any import clearance, including payment of any import duties and similar charges, in connection with any Products transferred to such Party under this Agreement.

  
 44 

	 	8.6.5.	 Payment Flows. The Parties recognize that this Agreement is global in nature and does not set out in detail how the financial flows will be
implemented at a legal entity level in order to achieve the economic sharing of profits and losses generated by the Products as set forth in this Agreement. At least eighteen (18) months prior to first commercial launch of a Product, the
Parties will discuss and agree upon the principles for such profit and loss sharing at a legal entity level. The Parties will use reasonable efforts to minimize the impact on both Parties of irrecoverable and/or non-creditable Indirect Taxes,
including, where appropriate, causing their local Affiliates to enter into a “Marketing Services Agreement” with one another or otherwise discussing how to address the issue. For clarity, the provisions of this Section 8.6.5 (Payment
Flows) will in no way change the allocation between the Parties of Development Costs and General Costs set forth in Section 7.2.8.1 (Costs) or of Net Revenues set forth in Section 7.2.8.2 (Profits). 

 

	8.7.	 Late Payment. Any payments or portions thereof due hereunder which are not paid when due will bear interest at the Contract Interest Rate,
compounded annually, calculated on the number of days such payment is delinquent. This Section 8.7 (Late Payment) will in no way limit any other remedies available to either Party. 

 

	8.8.	 Change in Accounting Periods. From time to time, either of the Parties may change its accounting and financial reporting practices from
calendar quarters and calendar years to fiscal quarters and fiscal years or vice versa. If a Party notifies the other in writing of a change in its accounting and financial reporting practices from calendar quarters and calendar years to fiscal
quarters and fiscal years or vice versa, then thereafter, beginning with the period specified in the notice, the Parties will cooperate to determine a way to report and reconcile each Party’s accounting periods so as to facilitate payments to
be made hereunder. 

 9.    DISTRACTING PRODUCTS 

 

	9.1.	 Distracting Program. Except as set forth in Sections 9.2 (Post-Effective Date Affiliates), 9.3 (Termination, Divestiture or Inclusion) and
9.4 (Pre-Clinical Research and Development Programs): 

  

	 	9.1.1.	 Partner will not, during the Term and, other than in the event of termination by Partner pursuant to Section 14.3 (Termination for Breach), for
[*] thereafter, itself or through its Affiliates, conduct or participate in, or advise, assist or intentionally enable any Third Party to conduct or participate in, any Distracting Program anywhere in the world; provided, that [*];

  

	 	9.1.2.	 Amgen will not, during the Term, itself or through its Affiliates, conduct or participate in, or advise, assist or intentionally enable any Third
Party to conduct or participate in, any Distracting Program in the Collaboration Territory; and 

  
 45 

	 	9.1.3.	 [*]. 

  

	9.2.	 Post-Effective Date Affiliates. If a Party enters into a Distracting Transaction then it will provide notice to the other Party, within [*]
business days after the closing of the Distracting Transaction, describing in reasonable detail, to the extent permitted by Applicable Law and without disclosing any proprietary information, the Distracting Program. During the pendency of any
potential Distracting Transaction, and until the provisions of Section 9.3 (Termination, Divestiture or Inclusion) are fully implemented, the Party entering into the Distracting Transaction will Segregate the Distracting Program from programs
for the Products. 

  

	9.3.	 Termination, Divestiture or Inclusion. The notice provided pursuant to Section 9.2 (Post-Effective Date Affiliates) will include a
notification as to whether the Party entering into the Distracting Transaction intends to Divest, terminate or include in the collaboration the Distracting Program in accordance with this Section 9.3 (Termination, Divestiture or Inclusion):

  

	 	9.3.1.	 Divestiture. If a Party elects to Divest the Distracting Program, then it will Segregate such Distracting Program from the programs for the
Products and Divest such Distracting Program within [*] months of the closing of the Distracting Transaction. The divesting Party and its Affiliates (including the Affiliate with the Distracting Program) will not directly or indirectly assert any
intellectual property or proprietary right embodied in the Distracting Program and under the control of the divesting Party or its Affiliates as a result of the Distracting Transaction, against or with respect to Products or otherwise obstruct the
Parties’ (or their Affiliates, sublicensees’, contractors’ or agents’) efforts under this Agreement or, if Partner is the divesting Party, Amgen’s (or its Affiliates, sublicensees’, contractors’ or agents’)
efforts with respect to Products in the Excluded Territory. If the divesting Party fails to complete a divestiture of the Distracting Program within [*] months of the closing of the Distracting Transaction, then such Party will be deemed to have
chosen to terminate the Distracting Program, effective as of such [*] month anniversary, and will promptly comply with the requirements of Section 9.3.2 (Termination); provided, that if at the expiration of such [*] month period, the
divesting Party has agreed terms with a Third Party to Divest the Distracting Program then such [*] month period will be extended as required for the divesting Party and such Third Party to consummate the transaction, but in no event will such
extension exceed an additional [*] days. 

  

	 	9.3.2.	 Termination. If a Party elects to terminate such Distracting Program, it will terminate all activities of such Distracting Program within [*]
days after the closing of the Distracting Transaction, during which period it will Segregate such Distracting Program from the programs for the Products. The terminating Party and its Affiliates will not directly or indirectly assert any
intellectual property or proprietary right of the Distracting Program against or with respect to Products or otherwise to obstruct the Parties’ (or their Affiliates, sublicensees’, contractors’ or agents’) efforts under this
Agreement or if Partner 

  
 46 

	 	 
is the terminating Party, Amgen’s (or its Affiliates, sublicensees’, contractors’ or agents’) efforts with respect to Products in the Excluded Territory during such
termination period or thereafter. 

  

	 	9.3.3.	 Inclusion. If a Party elects to include the Distracting Program in the collaboration, then such Party (the “Distracting Transaction
Party”) will provide written notice within [*] days after the closing of the Distracting Transaction of such election to the other Party, together with a non-confidential summary of the related Distracting Program. If the non-Distracting
Transaction Party desires to evaluate such Distracting Program, then the non-Distracting Transaction Party will notify the Distracting Transaction Party within [*] days of its receipt of such notice. Promptly after the Distracting Transaction
Party’s receipt of such evaluation notice, the Distracting Transaction Party will provide the non-Distracting Transaction Party with a confidential summary of the Distracting Program, including material pre-clinical and clinical data and
proposed development plan and budget (as well as such other information that the non-Distracting Transaction may reasonably request), which summary will be deemed to be Confidential Information of the Distracting Transaction Party under this
Agreement (and the non-Distracting Transaction Party shall be entitled to use such information solely for the purpose of evaluating whether to include such Distracting Program in the collaboration). Within [*] days of its receipt of such summary,
the non-Distracting Transaction Party will notify the Distracting Transaction Party of its election to either (i) include the Distracting Program in the collaboration or (ii) decline to include such Distracting Program in the
collaboration. If the non-Distracting Transaction Party agrees in writing to include such Distracting Program in the collaboration, then (a) the Distracting Program will be included under the terms of this Agreement and all the technology,
intellectual property and tangible materials (including biological compounds, chemical compounds, intermediates, assays, screens, animal models and reagents) of such Distracting Program will be considered within the Product Intellectual Property;
(b) the Distracting Products included in the Distracting Program will be deemed Products hereunder; (c) a JPT will be formed for each such Distracting Product and each such JPT will develop a Development Plan and Development Budget for
each Distracting Product, for review and approval by the JSC; (d) all Development Costs, General Costs and profits with respect to each such Distracting Product [*]; and (e) the Parties will enter into an amendment or supplement to this
Agreement to the extent necessary to specify which Party will be the Development Lead, Manufacturing Lead, and Commercial Lead, plus such other changes, modifications and assignments as are reasonably necessary to effectuate the addition of such
Distracting Product. If the non-Distracting Transaction Party does not agree to include such Distracting Program in the collaboration, then (i) from and after the date of such election, the obligations of the Distracting Transaction Party set
forth in Section 9.1 (Distracting Program) will no longer apply with respect to such Distracting Program, and (ii) the non-Distracting Party shall destroy the confidential summary of the Distracting Program provided to it by the
Distracting Transaction Party (provided, that the non-Distracting Party shall be 

  
 47 

	 	 
entitled to retain one (1) copy of such information for its record-keeping purposes). 

  

	9.4.	 Pre-Clinical Research and Development Programs. Notwithstanding anything in this Article 9 (Distracting Products), either Party will have the
right, either itself or through its Affiliates, to conduct non-clinical research and non-clinical development on any Distracting Product, subject to this Section 9.4 (Pre-Clinical Research and Development). At least [*] days prior to the
anticipated initiation of the first [*] for such Distracting Product, the Party conducting such activities (the “Researching Party”) will notify the non-Researching Party and provide a non-confidential summary of the related
Distracting Program to the non-Researching Party (“Program Notice”). If the non-Researching Party desires to evaluate such Distracting Program, then the non-Researching Party will notify the Researching Party within thirty
(30) days of its receipt of the Program Notice. Promptly after the Researching Party’s receipt of such evaluation notice, the Researching Party will provide the non-Researching Party with a confidential summary of the Distracting Program,
including material pre-clinical data and proposed development plan and budget (as well as such other information that the non-Researching Party may reasonably request), which summary will be deemed to be Confidential Information of the Researching
Party under this Agreement (and the non-Researching Party shall be entitled to use such information solely for the purpose of evaluating whether to include such Distracting Program in the collaboration). Within [*] days of its receipt of such
summary, the non-Researching Party will notify the Researching Party of its election to either (i) include the Distracting Program in the collaboration, in which case the terms of Section 9.3.3 (Inclusion) will apply with respect to such
Distracting Program (provided, that the Researching Party will be entitled to receive a [*]) or (ii) decline to include such Distracting Program in the collaboration. If the non-Researching Party declines to include such Distracting
Program in the collaboration, then (i) from and after the date of such election, the obligations of the Researching Party set forth in Section 9.1 (Distracting Program) will no longer apply with respect to such Distracting Program, and
(ii) the non-Researching Party shall destroy the confidential summary of the Distracting Program provided to it by the Researching Party (provided, that the non-Research Party shall be entitled to retain one (1) copy of such
information for its record-keeping purposes). 

  

	9.5.	 Reasonable Restrictions. Each of the Parties acknowledges the provisions of this Article 9 (Distracting Products) are reasonable and
necessary to protect the legitimate interests of the other Party and to encourage the free sharing of information between the Parties with respect to Products, and each of the Parties agrees not to contest such limitations in any proceeding. Each
Party acknowledges that the other Party would not have entered into this Agreement absent the restrictions set forth in this Article 9 (Distracting Products) and that a breach or threatened breach of this Article 9 (Distracting Products) would be
likely to result in irreparable harm to such Party for which there is no adequate remedy at law. Therefore, the Parties will be entitled to obtain from any court of competent jurisdiction injunctive relief, specific performance, and an equitable
accounting of any earnings, profits or benefits arising out of any such breach without the requirement to post a bond or to demonstrate irreparable harm, balancing of harms, consideration of the public

  
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interest or inadequacy of monetary damages as a remedy. Nothing in this Section 9.5 (Reasonable Restrictions) is intended or will be construed to limit in any way either Party’s right
to equitable relief or any other remedy for breach of this or any other provision of this Agreement. 

 10.
   INTELLECTUAL PROPERTY 
  

	10.1.	 Invention Ownership. Each Party will own all right, title, and interest in and to all Inventions that are made by or on behalf of such Party,
solely or independent of the other Party, and all intellectual property rights related thereto, and any Invention that is jointly made will be owned jointly by the Parties. Inventorship will be determined according to United States Patent Law
(without reference to any conflict of law principles). 

  

	10.2.	 Copyright Ownership; Certain Confidential Information. Each Party will own all right, title, and interest in and to all Copyrights created
pursuant to this Agreement that are authored by or on behalf of such Party, solely or independent of the other Party, and all intellectual property rights related thereto. The Parties will jointly own all right, title, and interest in and to all
Copyrights created pursuant to this Agreement that are authored by or on the behalf of the Parties jointly, and all intellectual property rights related thereto. Notwithstanding the foregoing, any Copyrights pertaining to Promotional Materials or
training materials for a Product will be owned solely by the Commercial Lead for such Product. 

  

	10.3.	 Joint Ownership. Except as expressly provided in this Agreement, it is understood that neither Party will have any obligation to obtain any
approval or consent of, nor pay a share of the proceeds to or account to, the other Party to practice, enforce, license, assign or otherwise exploit Inventions or intellectual property (including Copyrights and Product Trademarks) owned jointly by
the Parties hereunder, and each Party hereby waives any right it may have under the laws of any jurisdiction to require such approval, consent or accounting. Each Party agrees to cooperate with the other Party, as reasonably requested, and to take
such actions as may be required to give effect to this Section 10.3 (Joint Ownership) in a particular country within the Collaboration Territory. 

  
 49 

	10.4.	 License Grant by Amgen. Amgen hereby grants and causes its Affiliates to grant to Partner during the Term a [*], fully-paid, royalty-free
license to Amgen Intellectual Property and Program Intellectual Property solely (i) to the extent necessary to conduct the Designated Partner Activities and (ii) to exercise and perform Partner’s other rights and obligations under the
terms of this Agreement. Such license is sublicensable by Partner or its Affiliates solely in accordance with Section 6.4 (Use of Affiliates and Third Party Contractors). 

 

	10.5.	 License Grant by Partner. Partner hereby grants and causes its Affiliates to grant to Amgen and its Affiliates a [*], fully-paid,
royalty-free license to Partner Intellectual Property and Program Intellectual Property solely (i) to the extent necessary to conduct the Designated Amgen Activities and (ii) to exercise and perform Amgen’s other rights and
obligations under the terms of this Agreement. The foregoing license is sublicensable by Amgen or its Affiliates in accordance with Section 6.4 (Use of Affiliates and Third Party Contractors). Additionally, Partner hereby grants and causes its
Affiliates to grant to Amgen and its Affiliates a [*], irrevocable, fully-paid, royalty-free, world-wide license to Partner Intellectual Property and Program Intellectual Property solely to use, make, have made, sell, offer for sale and import
Products for all uses in the Excluded Territory (which license is sublicensable by Amgen or its Affiliates to Third Parties to whom Amgen or its Affiliates also grant a license in the Excluded Territory to Know-How or Patents owned or controlled by
Amgen with respect to Product(s) , or the manufacture, formulation or use thereof; [*]). 

  

	10.6.	 Prosecution and Maintenance. 

  

	 	10.6.1.	 Amgen Intellectual Property. Subject to the provisions of Section 2.10 (Patent Coordinators), Amgen will control, itself or through
outside counsel, and have final decision making authority (after consultation with Partner in accordance with the terms and conditions of this Agreement) with respect to the Prosecution and Maintenance of the Patents within the Amgen Intellectual
Property in the Collaboration Territory that claim a Product, and with respect to preparation and filing for any Patent Extensions. 

  

	 	10.6.2.	 Partner Intellectual Property. Subject to the provisions of Section 2.10 (Patent Coordinators), Partner will control, itself or through
outside counsel, and have final decision making authority (after consultation with Amgen in accordance with the terms and conditions of this Agreement) with respect to the Prosecution and Maintenance of the Patents within the Partner Intellectual
Property in the Collaboration Territory that claim a Product, and with respect to preparation and filing for any Patent Extensions. 

  

	 	10.6.3.	 Program Intellectual Property. Subject to the provisions of Section 2.10 (Patent Coordinators), Amgen will have the first right (but not
the obligation) to control, through outside counsel, and have final decision making authority (after consultation with Partner in accordance with the terms and conditions of this Agreement) with respect to the Prosecution and Maintenance of the
Patents and Product Trademarks within the Program Intellectual Property (the “Program Patents and Trademarks”), and with respect to preparation and filing for any

  
 50 

	 	 
Patent Extensions. If Amgen desires to abandon the prosecution of a Program Patent or Trademark, then it will inform Partner thereof in writing with sufficient advance notice to reasonably enable
Partner to assume the filing or prosecution of such Program Patent or Trademark (but in no event later than [*] days prior to the next deadline for any action that may be taken with respect such Program Patent or Trademark with the U.S. Patent and
Trademark Office or any non-U.S. patent office) at Partner’s non-reimbursable cost. 

  

	 	10.6.4.	 Review and Comment Rights - Patents. Through the Patent Coordinators: (i) the filing Party will provide the non-filing Party with copies
of and an opportunity to review and comment upon the text of the applications relating to the applicable Patents at least [*] days before filing; provided, that if it is not reasonably practicable to provide such application in such [*] day
period, then the filing Party will provide either a draft copy of such application or a statement of intent to file such application in such [*] day period; (ii) the filing Party will provide the non-filing Party with a copy of each submission
made to and document received from a patent authority, court or other tribunal regarding any Patent reasonably promptly after making such filing or receiving such document, including a copy of each application for each Patent as filed together with
notice of its filing date and application number; (iii) the filing Party will keep the non-filing Party advised of the status of all material communications, and actual and prospective filings or submissions regarding the Patents, and will give
the non-filing Party copies of and an opportunity to review and comment on any such material communications, filings and submissions proposed to be sent to any patent authority or judicial body; and (iv) the filing Party will consider in good
faith the non-filing Party’s comments on such communications, filings and submissions for the Patents. With respect to any filings or other materials provided to the non-filing Party under this Section 10.6 (Prosecution and Maintenance),
the filing Party will have the right to redact any manufacturing information and any information relating to any product other than Products from any such filings and materials. Either Patent Coordinator may escalate to the JSC whether to obtain any
license to Third Party Patents or Know-How; provided, that in the event of a disagreement at the JSC with respect to such decision, Amgen will make the final decision with respect thereto. 

 

	 	10.6.5.	 Review and Comment Rights - Product Trademarks. Through the Patent Coordinators: (i) the filing Party will provide the non-filing Party
with copies of and an opportunity to review and comment upon the text of each application relating to registration of a Product Trademark at least [*] business days before filing; (ii) the filing Party will provide the non-filing Party with a
copy of each submission made to and document received from a trademark registration authority, court or other tribunal regarding any Product Trademark reasonably promptly after making such filing or receiving such document, including a copy of each
application for registration of each Product Trademark as filed together with notice of its filing date and application number; (iii) the filing Party will keep the non-filing Party advised of the status of all material communications, and
actual and prospective filings or submissions regarding the application for 

  
 51 

	 	 
registration of Product Trademarks, and will give the non-filing Party copies of and an opportunity to review and comment on any such material communications, filings and submissions proposed to
be sent to any trademark registration authority or judicial body; and (iv) the filing Party will consider in good faith the non-filing Party’s comments on such communications, filings and submissions for the Product Trademarks.

  

	10.7.	 Defense and Settlement of Third Party Claims of Infringement. If a Third Party asserts that Patents, Know-How or other rights owned or
controlled by it are infringed by the activities hereunder of either of the Parties, then defense of such claim (an “Infringement Claim”) will be managed in accordance with the provisions of Section 13.4 (Defense of Third Party
Claims), with coordination and cooperation between the Defending Party and Assisting Party occurring via the Patent Coordinators. If either Party seeks to initiate a nullification, declaratory judgment, revocation, or opposition proceeding against
any such Patents, Know-How or other rights in response to prospective or actual Third Party Claims of Infringement, the Parties will coordinate and cooperate in regard to such proceedings in accordance with the procedures set forth in
Section 13.4 (Defense of Third Party Claims), with coordination and cooperation between the Defending Party and Assisting Party occurring via the Patent Coordinators. 

 

	10.8.	 Enforcement. Except as expressly set forth in this Section 10.8 (Enforcement), each Party will retain all its rights to control the
enforcement of its own intellectual property. Amgen will have the first right (but not the obligation) to enforce the Program Intellectual Property against any Third Party that is developing, manufacturing, selling, or importing a product or service
that competes with a Product; provided, that Partner will have the right to approve in writing any settlement of any claim, suit or action involving its intellectual property that admits the invalidity or unenforceability of its intellectual
property or imposes on Partner restrictions or obligations. If Amgen fails to bring any such action or proceeding within forty-five (45) days (or twenty-five (25) days in the case of an action brought under the Biologics Price
Competition and Innovation Act of 2009 (or any amendment or successor statute thereto) or within the time frame of any other relevant regulatory or statutory framework that may govern) of a request by Partner to do so (or, if sooner, five
(5) days before the time limit, if any, set forth in the relevant laws and regulations for the filing of such actions), or earlier notifies Partner in writing of its intent not to bring such action or proceeding, then Partner will have the
right (but not the obligation) to bring any such action or proceeding by counsel of its own choice; provided, that Amgen will have the right to approve in writing any settlement of any claim, suit or action involving its intellectual property
that admits the invalidity or unenforceability of its intellectual property or imposes on Amgen restrictions or obligations. The non-enforcing Party will reasonably assist the enforcing Party with respect to any such enforcement in the Collaboration
Territory, including, in the event that it is determined that the non-enforcing Party is an indispensable Party to such action, by being named as a Party in such action, and cooperate in any such action at the enforcing Party’s request. Without
limiting the foregoing, the enforcing Party will keep the non-enforcing Party advised of all material communications, actual and prospective filings or submissions regarding such action, and will provide the non-enforcing Party copies of and an

  
 52 

	 	 
opportunity to review and comment on any such material communications, filings and submissions (provided, that the enforcing Party will have the right to redact any manufacturing
information and any information relating to any product other than Products from any such materials). All Recoveries will be retained by or paid to Amgen (whether Amgen is the enforcing Party or not), but to the extent such Recoveries were obtained
with respect to a Product or a product that competes directly with a Product, the same shall be included in Net Revenues for the period in which such Recovery is made. 

 

	10.9.	 Patent Term Extensions. Each non-filing Party will provide reasonable assistance to the filing Party in connection with obtaining
supplementary protection certificates, patent term extensions or similar protection for Patents (“Patent Extensions”) within the Product Intellectual Property or otherwise licensed or assigned hereunder as determined by the Patent
Coordinators. To the extent reasonably and legally required to obtain any such Patent Extensions in a particular country, the non-filing Party will make available to the filing Party copies of all necessary documentation to enable the filing Party
to use the same for the purpose of obtaining Patent Extensions in such country. Notwithstanding Section 10.6 (Prosecution and Maintenance) above, the Patent Coordinator for the Commercial Lead will have the right to make the final decision as
to which Patents within the Amgen Intellectual Property, Partner Intellectual Property or Program Intellectual Property will be extended with respect to the Product(s) for which such Party is the Commercial Lead. 

 

	10.10.	 Trademarks. 

 10.10.1.         Title. The Parties will jointly own all right, title and interest in and to the Product Trademarks unless the local laws of any country
prohibit joint ownership in which case Amgen shall own the Product Trademarks in those countries. Neither Party will, and will ensure that its Affiliates do not: (i) challenge any Product Trademark or the registration thereof in any country;
(ii) file, register or maintain any registrations for any trademarks or trade names that are confusingly similar to any Product Trademark (other than for a Product), in any country without the express prior written consent of the other Party;
or (iii) authorize or assist any Third Party to do the foregoing. 

10.10.2.        Required Use and Compliance. 

10.10.2.1.    Promotional Materials and all packaging and package inserts for
Products in the Collaboration Scope will display the Amgen Housemarks and the Partner Housemarks to the extent allowed by Applicable Law and in accordance with the Brand Plan. Except for the use of the Amgen Housemarks and the Partner Housemarks as
may be expressly set forth in the Brand Plan, each Party will promote Products in the Collaboration Scope only under the Product Trademarks. 
 10.10.2.2.    Each Party agrees that it and its Affiliates will: (i) ensure that each use of the Product Trademarks and the other Party’s Housemarks by such Party is
accompanied by an acknowledgement that such Product Trademarks are jointly owned and such Housemarks are owned by the 

  
 53 

	 	 
other Party; (ii) not use such Product Trademarks or the other Party’s Housemarks in a way that might materially prejudice their distinctiveness or validity or the goodwill of the other
Party therein; and (iii) not use any trademarks or trade names so resembling any of such Product Trademarks or the other Party’s Housemarks as to be likely to cause confusion or deception. 

 

	 	10.10.3.	            Housemark Licenses. 

 

	 	10.10.3.1.	   To Partner. Amgen hereby grants to Partner a [*], royalty-free license to use the Amgen Housemarks solely as set forth in the
Promotional Materials and other materials provided to it by Amgen, and solely to develop, manufacture and commercialize Products in the Collaboration Scope in accordance with the Brand Plan, Country Plans and this Agreement.

  

	 	10.10.3.2.	   To Amgen. Partner hereby grants to Amgen a [*], royalty-free license to use the Partner Housemarks solely as set forth in the
Promotional Materials and other materials provided to it by Partner, and solely to develop, manufacture and commercialize Products in the Collaboration Scope in accordance with the Brand Plan, Country Plans and this Agreement.

  

	 	10.10.4.	              Respect of Trademarks. Partner will not have, assert or acquire
any right, title or interest in or to any Amgen Housemarks or the goodwill pertaining thereto, and Amgen will not have, assert or acquire any right, title or interest in or to any Partner Housemarks or the goodwill pertaining thereto, in each case
by means of entering into or performing under this Agreement, except in each case for the limited licenses explicitly provided in this Agreement. 

  

	 	10.10.5.	              Infringement. Each Party will monitor the Product Trademarks
against infringing uses within the Collaboration Scope and will promptly notify the other Party of any infringement or threatened infringement of any of the Product Trademarks of which it becomes aware. The Patent Coordinators will determine what
action, if any, to take in response to any such infringement or threatened infringement of any Product Trademark. 

 11.    CONFIDENTIALITY, PUBLICATIONS AND PRESS RELEASES 
  

	11.1.	 Confidentiality; Exceptions. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing, the Parties agree
that, during the Term and for [*] years thereafter, the receiving Party will keep confidential and will not publish or otherwise disclose or use for any purpose any and all information or materials related to the activities contemplated
hereunder that is furnished to it by the other Party pursuant to this Agreement and is identified by the disclosing Party as confidential, proprietary or the like or that the receiving Party has reason to believe is confidential based upon its own
similar information (collectively, “Confidential Information”). For clarity, except for rights expressly granted herein, both Parties will have no right to and will not utilize

  
 54 

	 	 
any Confidential Information of the other Party for activities outside the Collaboration Scope or for activities related to products other than the Products. Notwithstanding the foregoing,
Confidential Information will not include any information to the extent that it can be established by written documentation by the receiving Party that such information: 

 

	 	11.1.1.	 was obtained or was already known by the receiving Party or its Affiliates without obligation of confidentiality as a result of disclosure from a
Third Party that the receiving Party did not know was under an obligation of confidentiality to the disclosing Party with respect to such information; 

  

	 	11.1.2.	 was generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving Party through no act or
omission of the receiving Party or its Affiliates in breach of this Agreement; 

  

	 	11.1.3.	 became generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of
the receiving Party or its Affiliates in breach of this Agreement; or 

  

	 	11.1.4.	 was independently discovered or developed by the receiving Party or its Affiliates (without reference to or use of Confidential Information of the
disclosing Party). 

  

	11.2.	 Authorized Disclosure. Except as expressly provided otherwise in this Agreement, each Party may use and disclose Confidential Information of
the other Party solely as follows: (i) as reasonably necessary in conducting the activities contemplated under this Agreement; (ii) with respect to Confidential Information generated in the course of the activities conducted hereunder, to
the extent pertaining specifically to a Product, for use by Amgen in connection with a Product in the Excluded Territory or disclosure by Amgen to a partner or licensee for use with respect to a Product in the Excluded Territory; (iii) to the
extent such disclosure is to a Governmental Authority, as reasonably necessary in filing or prosecuting patent, copyright and trademark applications in accordance with this Agreement, prosecuting or defending litigation in accordance with this
Agreement, complying with applicable governmental regulations with respect to performance under this Agreement, filing Regulatory Filings, obtaining Regulatory Approval or fulfilling post-approval regulatory obligations for a Product, or otherwise
required by Applicable Law, provided, that if a Party is required by Applicable Law to make any such disclosure of the other Party’s Confidential Information it will, except where impracticable for necessary disclosures (for example, in
the event of medical emergency), give reasonable advance notice to the other Party of such disclosure requirement and, in the case of each of the foregoing exceptions pursuant to this subsection (iii), will use its reasonable efforts to secure
confidential treatment of such Confidential Information required to be disclosed; (iv) to advisors (including lawyers and accountants) on a need to know basis in support of the purposes of this Agreement, in each case under appropriate
confidentiality provisions or professional standards of confidentiality substantially equivalent to those of this Agreement; and (v) to the extent mutually agreed to by the Parties. Neither Party will disclose Confidential Information of the
other Party to its personnel or to an Affiliate except to the extent such personnel 

  
 55 

	 	 
or Affiliate needs to know such information for the performance of such Party’s activities hereunder. 

  
 56 

	11.3.	 Confidential Treatment of Terms and Conditions. The Parties agree that the terms and conditions of this Agreement will be Confidential
Information of each Party, and such material terms and conditions will not be disclosed, except (i) as otherwise permitted under Section 11.2 (Authorized Disclosure) and (ii) if required by Applicable Law (including disclosure of a
redacted version of this Agreement in a relevant SEC filing). Notwithstanding the foregoing, with respect to complying with the disclosure requirements of any Governmental Authority in connection with any required filing of this Agreement, the
Parties will consult with one another concerning which terms of this Agreement will be requested to be redacted in any public disclosure of this Agreement, and in any event each Party will seek reasonable confidential treatment for any public
disclosure by any such Governmental Authority. 

  

	11.4.	 Press Releases. Notwithstanding Section 11.3 (Confidential Treatment of Terms and Conditions), the Parties will issue a joint press
release to announce the execution of this Agreement, which is attached hereto as the Press Release Schedule (or such other joint press release as may be mutually agreed upon in writing by the Parties) and is for use in responding to inquiries about
this Agreement. Thereafter, Partner and Amgen may each disclose to Third Parties (including media interviews and disclosures to financial analysts) the information contained in such press release (but only such information) without the need for
further approval by the other; provided, that such information is still accurate. Each Party will have the right to issue additional press releases and disclosures in regards to the terms of this Agreement only with the prior written consent
of the other Party, such consent not to be unreasonably withheld (or as required to comply with Applicable Law). For any such proposed press release or disclosure, the disclosing Party will provide [*] business days’ notice to the other Party
and will reasonably consider the other Party’s comments that are provided within [*] business days after such notice, or such shorter notice and comment periods as are reasonably required under the circumstances but not less than [*] business
days. 

  

	11.5.	 Prior Agreement. This Agreement supersedes the Confidential Disclosure Agreement between Amgen and MedImmune, LLC (an Affiliate of
AstraZeneca) dated September 14, 2011, as amended and supplemented, including any written requests thereunder with respect to information disclosed thereunder relating to the Products and activities related thereto. All confidential information
exchanged between the Parties and their respective Affiliates under such agreement will be deemed Confidential Information of the disclosing Party disclosed hereunder and will be subject to the terms of this Agreement. 

 

	11.6.	 Publications and Program Information. Except as permitted pursuant to Section 3.5 (Clinical Trial Register), the Development Lead for a
Product will have the sole right to publish and make scientific presentations with respect to such Product, and to issue press releases (except with respect to the terms of this Agreement, which is governed by Section 11.4 (Press Releases)) or
make other public disclosures regarding any such Product (including with respect to its development, commercialization and regulatory matters), and the other Party will not do so without the Development Lead’s prior written

  
 57 

	 	 
consent, except as required by Applicable Law; provided, that any publication or presentation to be made by the Development Lead that names the other Party will require the prior consent
of the other Party. The Development Lead will keep the relevant committee or team informed of its general publication strategy and presentation calendar. The Development Lead will consider any reasonable comments regarding such strategy from the
other Party. In addition, the Development Lead will deliver to the other Party a copy of any proposed written publication or outline of presentation to be made by the Development Lead with respect to any scientific data pertaining to a Product in
the Collaboration Scope in advance of submission for publication or presentation at least [*] days in advance of submission (or, where a copy of such publication or presentation is not available at such time, a draft or outline of such publication
or a description of such presentation), and the other Party will have the right to: (i) require a delay in submission of not more than [*] days to enable patent applications protecting the other Party’s rights in Inventions owned by such
Party; and (ii) prohibit disclosure of any of its Confidential Information in any such proposed publication or presentation. Publications and presentations will be subject to policies mutually agreed by the Patent Coordinators to ensure
appropriate protection of intellectual property rights. If there is any dispute between the Parties with regard to a proposed publication, presentation or other communication regarding this Agreement, such dispute shall be referred to the JSC for
resolution (with the Development Lead for the Product having the final decision). 

  

	12.	 REPRESENTATIONS AND WARRANTIES 

  

	12.1.	 Mutual Representations and Warranties. Each of the Parties hereby represents and warrants, as of the Effective Date to the other Party as
follows: 

  

	 	12.1.1.	 It is duly organized and validly existing under the Applicable Law of its jurisdiction of incorporation and it has full corporate power and
authority and has taken all corporate action necessary to enter into and perform this Agreement; 

  

	 	12.1.2.	 This Agreement is a legal and valid obligation binding upon such Party and enforceable in accordance with its terms. The execution, delivery and
performance of this Agreement, and compliance with its terms and provisions, and the consummation of the transaction contemplated hereby, by such Party will not materially conflict, interfere or be inconsistent with, result in any material breach of
or constitute a material default under, any agreement, instrument or understanding, oral or written, to which it is a party or by which it is bound, nor to its knowledge violate any Applicable Law. The person or persons executing this Agreement on
such Party’s behalf have been duly authorized to do so by all requisite corporate action; 

  

	 	12.1.3.	 It has not been debarred or the subject of debarment proceedings by any Governmental Authority; 

  
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	 	12.1.4.	 To its knowledge, it and its Affiliates have not violated any Anti-Corruption Law; and 

 

	 	12.1.5.	 It has not granted any right to any Third Party relating to any intellectual property or proprietary right licensed, granted or assigned by it to
the other Party hereunder that conflicts with the rights licensed, granted or assigned to the other Party hereunder. 

  

	12.2.	 Amgen Representations and Warranties. In addition to the representations and warranties set forth in Section 12.1 (Mutual
Representations and Warranties), Amgen hereby represents and warrants to Partner that, as of the Effective Date: 

  

	 	12.2.1.	 Amgen has not received written notice from any Third Party that any issued and enforceable Patent of such Third Party would be infringed by the
importation, manufacture, distribution, marketing or sale of a Product (except, in each case, where Amgen may have since such time obtained a license to the relevant Patent); 

 

	 	12.2.2.	 Amgen is the sole owner of all right, title and interest in the Patents included within Amgen Intellectual Property or otherwise has the right to
grant to Partner the rights to such Patents, and the Amgen Intellectual Property is not subject to any lien or other encumbrance in favor of any Third Party that conflicts with the rights or licenses of Partner hereunder;

  

	 	12.2.3.	 No patent application or registration within the Amgen Intellectual Property is the subject of any pending interference, opposition, cancellation,
or patent protest pursuant to 37 C.F.R. §1.291; 

  

	 	12.2.4.	 To Amgen’s knowledge, no Third Party is [*] in the Collaboration Scope; 

 

	 	12.2.5.	 To Amgen’s knowledge, the development of the Products in the Collaboration Scope by or on behalf of Amgen [*]; 

 

	 	12.2.6.	 To Amgen’s knowledge, there is no [*]. For the purposes of this Section 12.2.6, “[*]” does not include claims for [*] for the
[*] related to [*]; 

  

	 	12.2.7.	 Amgen has made available to Partner true and correct copies of the following: (i) all material Regulatory Filings for the Collaboration
Territory; (ii) all material correspondence with Governmental Authorities with respect to such Regulatory Filings; (iii) all minutes of any material meetings, telephone conferences or discussions with Governmental Authorities with respect
to such Regulatory Filings; and (iv) all final clinical trial reports, in each case with respect to the Products and to the extent in existence as of the Effective Date; 

 

	 	12.2.8.	 Amgen is the owner of [*] Regulatory Filings for the Products in the Collaboration Scope; 

 

	 	12.2.9.	 Except as would not be reasonably expected to have a material adverse effect on the development, manufacture or commercialization of Products, Amgen
has filed with the relevant Governmental Authorities all required notices, amendments and annual reports, as well as adverse event reports, with respect to the Regulatory Filings for the Products in the Collaboration Scope in existence

  
 59 

	 	 
as of the Effective Date; 

 12.2.10.            To Amgen’s knowledge, there is no pending action or action threatened in writing by relevant Governmental Authorities
to place a clinical hold order on, or otherwise terminate or suspend, any of the Regulatory Filings for a Product in existence as of the Effective Date; 

12.2.11.            The Completed Clinical
Trials Schedule contains a complete list of all clinical trials carried out by or on behalf of Amgen or its Affiliates in relation to the Products for which dosing of patients was completed before the Effective Date; 

12.2.12.            Amgen has provided
Partner with true and correct copies of [*]; 

12.2.13.            No written notice has
been given or received by Amgen that [*] prior to the Effective Date; and 

12.2.14.            Amgen has [*].

  

	12.3.	 Mutual Covenants. Each Party hereby covenants to the other Party that, during the Term: 

 

	 	12.3.1.	 it will not grant any right to any Third Party relating to any intellectual property or proprietary right licensed or assigned by it to the other
Party hereunder that conflicts with the rights granted to the other Party hereunder; 

  

	 	12.3.2.	 it will not knowingly use in connection with the research, development, manufacture or commercialization to take place pursuant to this Agreement
any employee, consultant or investigator that has been debarred or the subject of debarment proceedings by any regulatory agency; and 

12.3.3. Each Party agrees, on behalf of itself, its officers, directors and employees and on behalf of
its Affiliates, agents, representatives, consultants and subcontractors hired in connection with the subject matter of his Agreement (together with the Party, the “Party Representatives”) that in connection with any Designated
Partner Activities or Designated Amgen Activities, as applicable: 

12.3.3.1.    Each Party’s respective Party Representatives shall not directly
or indirectly pay, offer or promise to pay, or authorize the payment of any money, or give, offer or promise to give, or authorize the giving of anything else of value, to: 

 

	 	(i)	 any Government Official in order to influence official action; 

 

	 	(ii)	 any Person (whether or not a Government Official) (a) to influence such Person to act in breach of a duty of good faith, impartiality or trust
(“acting improperly”), (b) to reward such Person for acting improperly, or (c) where such Person would be acting improperly by receiving the money or other thing of value; 

 

	 	(iii)	 any other Person while knowing or having reason to know that all or any portion of the money or other thing of value will be

  
 60 

	 	 
paid, offered, promised or given to, or will otherwise benefit, a Government Official in order to influence official action for or against either Party in connection with the matters that are the
subject of this Agreement; or 

  

	 	(iv)	 any Person to reward that Person for acting improperly or to induce that Person to act improperly. 

12.3.3.2.    Each Party’s Party Representatives shall not, directly or
indirectly, solicit, receive or agree to accept any payment of money or anything else of value in violation of the Anti-Corruption Laws. 
 12.3.3.3.    Each Party, on behalf of itself and its other Party Representatives, represents and warrants to the other Party that for the term of this Agreement and [*] thereafter each
Party shall maintain accurate books and reasonably detailed records in connection with the performance of its obligation under this Agreement including all records required to establish compliance with Sections 12.3.3.1 and 12.3.3.2 above.

 12.3.3.4.    Each Party shall promptly provide the other Party with
written notice of the following events: 
  

	 	(a)	 Upon becoming aware of any breach or violation by a Party or its Party Representative of any representation, warranty or undertaking set forth in
Sections 12.3.3.1 and 12.3.3.2. 

  

	 	(b)	 Upon receiving a formal notification that it is the target of a formal investigation by a Governmental Authority for a Material Anti-Corruption Law
Violation or upon receipt of information from any of its Party Representatives connected with this Agreement that any of them is the target of a formal investigation by a Governmental Authority for a Material Anti-Corruption Law Violation.

  

	12.4.	 Amgen Covenant. Except as would not be reasonably expected to have a material adverse effect on the development, manufacture or
commercialization of Products, Amgen and its Affiliates will [*]. Amgen will notify Partner in writing of any [*]. 

  

	12.5.	 AstraZeneca Covenant. [*]. 

  

	12.6.	 Disclaimer of Warranties. EXCEPT AS SET FORTH IN THIS ARTICLE 12 (REPRESENTATIONS AND WARRANTIES), PARTNER AND AMGEN EXPRESSLY DISCLAIM ANY
AND ALL REPRESENTATIONS AND WARRANTIES, EXPRESS, IMPLIED, STATUTORY OR OTHERWISE, WITH RESPECT TO THE COLLABORATION, PRODUCT INTELLECTUAL PROPERTY, AMGEN HOUSEMARKS, PARTNER HOUSEMARKS, PRODUCT TRADEMARKS, THIS AGREEMENT, OR ANY OTHER SUBJECT MATTER
RELATING TO THIS AGREEMENT, INCLUDING ANY WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR 

  
 61 

	 	 
PURPOSE, VALIDITY OR NONINFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS. 

  

	12.7.	 Limitation of Liability. NOTWITHSTANDING ANY OTHER PROVISION CONTAINED HEREIN, OTHER THAN TO THE EXTENT RESULTING FROM A PARTY’S BREACH
OF ARTICLE 9 (DISTRACTING PRODUCTS) OR SECTION 11.1 (CONFIDENTIALITY; EXCEPTIONS), IN NO EVENT WILL PARTNER OR AMGEN BE LIABLE TO THE OTHER PARTY OR ANY OF ITS AFFILIATES FOR ANY CONSEQUENTIAL, INCIDENTAL, INDIRECT, SPECIAL, PUNITIVE OR EXEMPLARY
DAMAGES (INCLUDING LOST PROFITS, BUSINESS OR GOODWILL) SUFFERED OR INCURRED BY SUCH OTHER PARTY OR ITS AFFILIATES IN CONNECTION WITH A BREACH OR ALLEGED BREACH OF THIS AGREEMENT. THE FOREGOING SENTENCE WILL NOT LIMIT THE OBLIGATIONS OF EITHER PARTY
TO INDEMNIFY THE OTHER PARTY FROM AND AGAINST SUCH DAMAGES AS ARE AWARDED TO A THIRD PARTY WITH RESPECT TO THIRD PARTY CLAIMS UNDER SECTION 13.1 (INDEMNITY BY PARTNER) OR SECTION 13.2 (INDEMNITY BY AMGEN). 

 

	13.	 INDEMNIFICATION AND INSURANCE 

  

	13.1.	 Indemnity by Partner. Partner will defend, indemnify, and hold harmless Amgen, its Affiliates, and their respective directors, officers,
employees, agents and representatives (collectively, “Amgen Indemnitees”), at Partner’s cost and expense, from and against any and all liabilities, losses, costs, damages, fees or expenses (including reasonable legal expenses
and attorneys’ fees) (collectively, “Losses”) arising out of any Third Party Claims brought against any Amgen Indemnitee to the extent such Losses result from: [*]. The indemnification obligations under this Section 13.1
(Indemnity by Partner) exclude Losses to the extent they arise from [*] below in Section 13.2 (Indemnity by Amgen). 

  

	13.2.	 Indemnity by Amgen. Amgen will defend, indemnify, and hold harmless Partner, its Affiliates, and their respective directors, officers,
employees, agents and representatives (collectively, “Partner Indemnitees”), at Amgen’s cost and expense, from and against any and all Losses arising out of any Third Party Claims brought against any Partner Indemnitee to the
extent such Losses result from: [*]. The indemnification obligations under this Section 13.2 (Indemnity by Amgen) exclude Losses to the extent they arise from [*] above in Section 13.1 (Indemnity by Partner). 

 

	13.3.	 Claim for Indemnification. Whenever any Third Party Claim or Loss arises for which a Partner Indemnitee or an Amgen Indemnitee (the
“Indemnified Party”) may seek indemnification under this Article 13 (Indemnification and Insurance), the Indemnified Party will promptly notify the other Party (the “Indemnifying Party”) of the Third Party Claim or
Loss; provided, that the failure by an Indemnified Party to give such notice will not relieve the Indemnifying Party of its indemnification obligation under this Agreement except and only to the extent that the Indemnifying Party is actually
prejudiced as a result of such 

  
 62 

	 	 
failure. The Indemnifying Party will have exclusive control of the defense and settlement of all Third Party Claims for which it is responsible for indemnification and will assume defense thereof
at its own expense promptly upon notice of such Third Party Claim. In no event will the Indemnifying Party settle any Third Party Claim without the prior written consent of the Indemnified Party if such settlement (x) does not include a
complete release from liability on such Third Party Claim, or (y) includes any admission of wrongdoing by the Indemnified Party or that any intellectual property or proprietary right of the Indemnified Party is invalid or unenforceable. The
Indemnified Party will have the right to employ separate counsel at the Indemnifying Party’s expense and to control its own defense of the applicable Third Party Claim if: (i) there are or may be legal defenses available to the Indemnified
Party that are different from or additional to those available to the Indemnifying Party; or (ii) in the reasonable opinion of counsel to the Indemnified Party, a conflict or potential conflict exists between the Indemnified Party and
Indemnifying Party that would make such separate representation advisable. 

  

	13.4.	 Defense of Third Party Claims. Except as otherwise provided in Section 13.3 (Claim for Indemnification), each Party (such Party referred
to as the “Defending Party”) will have the sole right, but not the obligation, to defend against any Third Party Claims made against it with respect to its activities hereunder; provided, that any Third Party Claims relating
to a nullification, declaratory judgment, opposition or revocation proceeding against any Product Intellectual Property will be governed by the provisions of Section 10.8 (Enforcement). Each Party will notify the other Party (the
“Assisting Party”) as promptly as practicable if any such Third Party Claim is commenced or threatened against it, including any Infringement Claim. The Assisting Party will reasonably assist the Defending Party and cooperate in any
such litigation at Defending Party’s reasonable request. Without limiting the foregoing, the Defending Party will keep the Assisting Party advised of all material communications, actual and prospective filings or submissions regarding such
action, and will provide the Assisting Party copies of and an opportunity to review and comment on any such communications, filings and submissions; provided, that each Party will have the right to redact from any information disclosed to the
other hereunder any information relating to a product other than a Product or relating to the manufacture of a Product. The Defending Party will control the defense and settlement of Third Party Claims, with the costs thereof being included in
General Costs, to the extent provided in Section 1.65.4. The Defending Party will not settle such Third Party Claim without the prior written consent of the other Party (such consent not to be unreasonably withheld), unless such settlement:
[*]. In the event that a Third Party Claim is brought against both of the Parties (a “Joint Claim”), then the Parties will determine whether to defend against such Joint Claim, which of the Parties should be the Defending Party or
whether the Parties should jointly control such defense and the strategy for such defense. In the case of an Infringement Claim, the coordination and cooperation set forth in this Section 13.4 (Defense of Third Party Claims) will be
accomplished via the Patent Coordinators. This Section 13.4 (Defense of Third Party Claims) will not apply to employment or similar personnel-related claims. 

 

	13.5.	 Insurance. Each of the Parties will, at their own 

  
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respective expense (and not subject to cost sharing hereunder) procure and maintain during the Term, insurance policies adequate to cover their obligations hereunder and consistent with the
normal business practices of prudent pharmaceutical companies of similar size and scope (or reasonable self-insurance sufficient to provide materially the same level and type of protection). Such insurance will not create a limit to either
Party’s liability hereunder. 

 14. TERM AND TERMINATION 

 

	14.1.	 Term. This Agreement will become effective on the Effective Date and will continue during the Term. 

 

	14.2.	 Termination for Convenience. 

  

	 	14.2.1.	 Either Party will have the right to terminate this Agreement, either in whole or on a Product-by-Product basis, by providing the other Party with
[*] prior written notice (or, after First Commercial Sale of a Product, [*] prior written notice with respect to such Product); provided, that a notice of termination with respect to a particular Product may only be provided after the
Continued Development Meeting for such Product has occurred and a notice of termination with respect to the Agreement in whole may only be provided after the Continued Development Meetings for all Products have occurred.

  

	 	14.2.2.	 [*]. 

  

	14.3.	 Termination for Breach. In the event of a material breach of this Agreement, the non-breaching Party will have the right to terminate this
Agreement, either in whole or (if such breach solely applies to a specific Product(s)) with respect to the applicable Product(s). The non-breaching Party may terminate this Agreement, whether in its entirety or on a Product-by-Product basis (as
applicable), by written notice to the breaching Party, which notice will specify the nature of such breach in reasonable detail. Such termination will become effective on the date that is [*] days after the delivery thereof to the breaching Party
(or, in the case of a failure to pay amounts due hereunder, [*] days) unless, during the [*] day (or [*] day) period after delivery of such notice to the breaching Party, the breaching Party has cured such breach to the reasonable satisfaction of
the non-breaching Party. Notwithstanding the foregoing, in the event of a good faith dispute as to whether performance has been made by either Party pursuant to this Agreement, including any good faith dispute as to payments due under this
Agreement, the relevant cure period with respect thereto will be tolled pending resolution of such dispute in accordance with the applicable provisions of this Agreement; provided, that if such dispute relates to payment, the cure period will
only apply with respect to payment of disputed amounts, and not with respect to undisputed amounts. 

  

	14.4.	 Termination for Insolvency. Either Party will have the right to terminate this Agreement immediately upon written notice, if: (i) the
other Party becomes insolvent; (ii) the other Party files a petition in bankruptcy, or if an involuntary petition in bankruptcy is filed against the other Party and such involuntary petition is not dismissed within seventy-five (75) days
and the other Party (a) fails to assume this Agreement in any such bankruptcy proceeding 

  
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within thirty (30) days after filing or (b) assumes and assigns this Agreement to a Third Party; or (iii) a receiver or guardian has been appointed for the other Party who is not
discharged within seventy-five (75) days after appointment. 

  

	14.5.	 Termination for Challenge. Either Party will have the right to terminate this Agreement on a Product-by-Product basis by written notice to
the other Party, if such other Party, its Affiliates or licensees bring or join any challenge to the validity or enforceability of (i) if Amgen is the challenging Party, any Partner Intellectual Property or any Program Intellectual Property, in
each case as and to the extent such Partner Intellectual Property or Program Intellectual Property applies to the Product in the Collaboration Scope that is the subject of the termination notice; and (ii) if Partner is the challenging Party,
any Amgen Intellectual Property (or any intellectual property corresponding to any such Amgen Intellectual Property in the Excluded Territory) or any Program Intellectual Property, in each case as and to the extent such Amgen Intellectual Property
or Program Intellectual Property applies to a Product in the Collaboration Scope that is the subject of the termination notice. Notwithstanding the foregoing, nothing in this Section 14.5 (Termination for Challenge) will either:
(a) prevent either Party from asserting any defense or counterclaim in an action for infringement of intellectual property, brought against such Party or its Affiliates, or any Third Party that such Party or any of its Affiliates is obligated
to indemnify, or responding in any other manner to such an action for infringement; or (b) allow a Party to terminate this Agreement in the event the other Party asserts any such defense or counterclaim or otherwise responds in any such action
for infringement. 

  

	14.6.	 Effects of Termination. 

  

					
	14.6.1.	 	 Product by Product Termination. Upon the termination of this Agreement by a Party with respect to one or more Products (each, a
“Terminated Product”), the following will apply:

		
		 	 14.6.1.1.    Termination of Product. Each Terminated Product will
thereafter cease to be a Product for all purposes of this Agreement; and accordingly, for purposes of this Section 14.6 (Effects of Termination):

			
		 		 	 (i)           “Continuing Party” means the Party that is not the Terminating
Party;

			
		 		 	 (ii)          “Continuing Scope” means with respect to a particular Terminated Product, the uses,
countries and territories within the Collaboration Scope for such Terminated Product immediately prior to the Termination Effective Date; 

			
		 		 	 (iii)         “Termination Effective Date” means, with respect to a particular Terminated Product, the
effective date of such termination with respect to such Terminated Product;

			
		 		 	 (iv)          “Terminated Product Intellectual Property Rights” means (a) the Terminating
Party’s rights in and to the Program Intellectual Property and (b) (1) to the extent the Terminating Party is Amgen, the Amgen Terminated Product IP or (2) to the extent the Terminating Party

  
 65 

 
is Partner, the Partner Terminated Product IP. For such purposes, “Amgen Terminated Product IP” and “Partner Terminated Product IP” mean, respectively, Amgen
Intellectual Property and Partner Intellectual Property, but substituting for each reference to “Product” and “Product Trademark” therein, “Terminated Product” and “Terminated Product
Trademark,” respectively; and 
 (v)
        “Terminated Product Promotional Materials” and “Terminated Product Trademarks” mean, respectively, Promotional Materials and Product Trademarks with respect to the
Terminated Product (i.e., for such purposes, substituting in the definition of Promotional Materials and Product Trademark a reference to “Terminated Product” for each reference to “Product”). 

(vi)         “Terminating Party” means (a) the Party
terminating the Agreement in the case of termination pursuant to Section 14.2 (Termination for Convenience); (b) the non-breaching Party in the case of termination pursuant to Section 14.3 (Termination for Breach); (c) the
non-insolvent Party in the case of termination pursuant to Section 14.4 (Termination for Insolvency); and (d) the non-challenging Party in the case of termination pursuant to Section 14.5 (Termination for Challenge). 

14.6.1.2.       Accrued Obligations.
    Termination of this Agreement with respect to a Terminated Product will not release either Party from any liability (including any payment obligations) with respect to such Terminated Product that, at the time of such
termination, has already accrued to the other Party or which is attributable to activities prior to such termination. 
 14.6.1.3.       Continuing Party’s Rights.     The Continuing Party will have the sole right, as between the Parties, to develop, manufacture
and commercialize the Terminated Product within the Continuing Scope. Accordingly, upon the Termination Effective Date for such Terminated Product, or such earlier time as specified below, and in each case subject to Section 14.6.1.5
(Amgen’s Rights Outside Continuing Scope) below: 
 (i)
        Terminated Product Intellectual Property Rights.     The Terminating Party will grant, and hereby grants, to the Continuing Party an exclusive, royalty-free license,
including the right to grant and authorized sublicenses, under the Terminated Product Intellectual Property Rights to make, have made, use, sell, offer for sale and import the Terminated Product within the Continuing Scope. The Terminating Party
will, subject to clause (vii) of this Section 14.6.1.3, immediately cease all of its development, manufacturing and commercialization activities for the Terminated Product. 

(ii)         Assignment of Trademarks.   The Terminating Party
will assign, and hereby assigns, to the Continuing Party all of the Terminating Party’s rights, title and interest in and to the Terminated Product Trademarks for such Terminated Product (including any goodwill associated therewith), including
all registrations therefore. Accordingly, the Terminating Party 

  
 66 

 
will cease all use of such Terminated Product Trademark. 

(iii)        Terminated Product Data.    The
Terminating Party will promptly transfer to the Continuing Party, at no cost, copies of all data, reports, records, materials and other Know-How in its possession or control that relate to the Terminated Product (“Terminated Product
Data”), with such data to the extent they relate specifically to the Terminated Product becoming the Continuing Party’s Confidential Information and shall cease to be the Terminating Party’s Confidential Information. The
Terminated Product Data will be provided in electronic form reasonably usable by the Continuing Party and, if reasonably necessary or useful in connection with the Continuing Party’s (or its designee’s) further commercialization,
development or exploitation of the Terminated Product within the Continuing Scope, will include original hardcopies or duplicate copies thereof, as required. 
 (iv)        Return of Confidential Information.    The Terminating Party will promptly return to the Continuing Party, or destroy at the
Continuing Party’s request (and certify such destruction to the Continuing Party), all relevant records and materials in the Terminating Party’s possession or control containing Confidential Information of the Continuing Party that is:
(a) related to the Terminated Product within the Continuing Scope and (b) not reasonably necessary for the Terminating Party to exercise any remaining rights or fulfill any remaining obligations it has under this Agreement after such
termination; provided, that the Terminating Party (1) may keep one copy of such Confidential Information of the Terminating Party for archival purposes or as otherwise required under Applicable Law; and (2) ensures such copies are
Segregated from any Distracting Program). 
 (v)         Return
of Samples and Materials.    The Terminating Party will promptly transfer to the Continuing Party, or destroy at the Continuing Party’s request (and certify such destruction to the Continuing Party), all samples,
Terminated Product Promotional Materials, sales training materials and any other documents, or materials primarily intended for use in commercialization of the Terminated Product within the Continuing Scope. 

(vi)        Assignment of Regulatory Filings and Approvals; Copyrights; Domain
Names.    The Terminating Party will, at its own expense (other than with respect to any fee payable to the relevant Governmental Authority in connection with the relevant assignment, which will be borne by the Continuing
Party), assign, and hereby assigns, to the Continuing Party all Regulatory Filings and Regulatory Approvals related to the Terminated Product within the Continuing Scope, and all copyrights, copyright registrations, domain names and domain name
registrations related to the Terminated Product (or to the Terminated Product Promotional Materials) within the Continuing Scope. The Terminating Party will promptly submit any necessary notices to

  
 67 

 
Governmental Authorities to effect such assignments. If Applicable Laws prevent or delay the transfer of ownership of any such Regulatory Filing or Regulatory Approval to the Continuing Party,
the Terminating Party will grant, and does hereby grant, to the Continuing Party an exclusive and irrevocable right of access and reference to such Regulatory Filing and Regulatory Approvals for purposes of developing and commercializing the
Terminated Product within the Continuing Scope, and will cooperate fully to make the benefits of such Regulatory Filings and Regulatory Approvals available to the Continuing Party or its designee(s) for purposes within the Continuing Scope for such
Terminated Product. Promptly upon request following the notice of termination, the Terminating Party will provide to the Continuing Party copies of all such Regulatory Filings and Regulatory Approvals. For purposes of this Section 14.6.1
(Product by Product Termination), references to Product in the defined terms Regulatory Filings and Regulatory Approvals shall be replaced with references to Terminated Product. 

(vii)      Transition.   During the applicable notice period prior to the
Termination Effective Date, the Terminating Party will continue to meet its obligations to develop, manufacture, and commercialize Products within the Collaboration Scope, in accordance with the applicable Development Plan, Brand Plan and Country
Plan and this Agreement and bear its proportionate share of expenses with respect thereto, unless otherwise agreed by the Parties or specified in this Section 14.6 (Effects of Termination). Upon request by the Continuing Party, the Terminating
Party will undertake reasonable efforts to effect a smooth and orderly transition of all development, manufacturing and commercial activities and responsibilities under this Agreement with respect to the Terminated Product to the Continuing Party
(or, in the case of manufacturing activities, to a mutually agreed upon Third Party contract manufacturer), as soon as reasonably possible, to enable the Continuing Party to continue the development, manufacturing and commercialization of the
Terminated Product in the Continuing Scope. Without limiting the foregoing: 

A.        Continued Supply.   The Terminating Party will
transfer to the Continuing Party all quantities of the Terminated Product in its possession for which the manufacturing costs were shared by the Parties under Article 7 (Profit/Expense Sharing). In addition, the Terminating Party will, at the
Continuing Party’s cost and expense, reasonably cooperate, as requested by the Continuing Party, to ensure uninterrupted supply of the Terminated Product. To the extent the Terminating Party was responsible for manufacturing the Terminated
Product as of the Termination Effective Date, then the Terminating Party will continue to provide for manufacturing of such Terminated Product for the Continuing Party, at the fully-burdened manufacturing cost therefore, from the date of notice of
such termination with respect 

  
 68 

 
to such Terminated Product, until the sooner to occur of such time as the Continuing Party is able, using Commercially Reasonable Efforts to do so, to secure an acceptable alternative
manufacturing source from which sufficient quantities of Terminated Product may be procured or [*] months from the Termination Effective Date. 
 B.       Contracts. If the Terminating Party is, as of the Termination Effective Date, party to any Third Party contracts that pertain solely to the Continuing
Scope with respect to a Terminated Product, then it will provide the Continuing Party notice and (to the extent permitted to do so) copies thereof; and the Terminating Party will assign to the Continuing Party any such contracts requested by the
Continuing Party, to the extent it has the right under such contract(s) to do so (and will use Commercially Reasonable Efforts to obtain any required consents). 

14.6.1.4.      Distracting Products.   Notwithstanding
anything herein to the contrary, if Amgen is terminating this Agreement pursuant to Section 14.2 (Termination for Convenience), Article 9 (Distracting Products) will continue to apply with respect to the Terminated Product for [*] thereafter.
In addition, for any termination hereunder, with respect to Article 9 (Distracting Product), each reference to “Product” or “Product Target” in the definitions of Distracting Product and Distracting Target will be
deemed to a reference to include the Terminated Product and the Product Target corresponding to such Terminated Product. 
 14.6.1.5.      Amgen’s Rights outside Continuing Scope.  Notwithstanding the foregoing provisions of this Section 14.6.1 (Product by Product
Termination): 
 (i)       Terminated Product Intellectual Property
Rights.   Partner will grant, and hereby grants (effective upon the Termination Effective Date), to Amgen an [*], royalty-free, [*] license, including the right to grant and authorize sublicenses, under the Partner Terminated Product
IP and Partner’s rights in and to the Program Intellectual Property to use, sell, offer for sale and import Terminated Products in the Excluded Territory, and to make and have made the Terminated Product for use and sale in the Excluded
Territory, and the last sentence of Section 2.2 (Ex-Territory Activities) shall continue to apply with respect to the Terminated Product. In addition, Amgen will retain, and not assign to Partner, Amgen’s right, title or interest in the
Terminated Product Trademarks in the Excluded Territory. 

(ii)      Terminated Product Data.   If Amgen is the Terminating Party
with respect to a Terminated Product, upon request by Amgen from time to time, Partner will promptly provide to Amgen at no cost, copies of Terminated Product Data then in Partner’s possession or control that relate to such Terminated Product,
for use in the Excluded Territory in relation to the Terminated Product. Such Terminated Product Data will be provided in electronic form reasonably usable by Amgen and, if 

  
 69 

 
reasonably necessary or useful in connection with Amgen’s (or its designee’s) further commercialization, development or exploitation of Terminated Products in the Excluded Territory,
will include original hardcopies or duplicate copies thereof, as required. 
 (iii)
      Regulatory Filings; Regulatory Approvals.   Partner will grant, and does hereby grant (effective upon the Termination Effective Date), to Amgen an exclusive and irrevocable right of access and
reference to any and all Regulatory Filings and Regulatory Approvals for the Terminated Product for purposes in the Excluded Territory, and will cooperate fully to make the benefits of such Regulatory Filings and Regulatory Approvals available to
Amgen or its designee(s) for purposes in the Excluded Territory. Promptly upon request by Amgen from time to time, Partner will provide to Amgen copies of all Regulatory Filings and Regulatory Approvals (and all underlying data) with respect to such
Terminated Product held by or on behalf of Partner. 
 (iv)       Excluded
Territory Agreements.   In the event that Amgen is the Terminating Party for either AMG827 or AMG557, Partner, at the request of Amgen, will enter into good faith negotiations for the purpose of establishing direct communications and
engagement between Partner and (i) Kirin-Amgen, Inc., in the case of AMG827, and (ii) Takeda Pharmaceutical Company Limited, in the case of AMG557, as necessary to fulfill Amgen’s obligations under the applicable Excluded Territory
Agreement. 
 14.6.1.6.      Royalty Payment. On a Terminated
Product-by-Terminated Product basis, other than with respect to the AMG157 Termination Event, the Continuing Party will pay to the Terminating Party a tiered royalty on aggregate Terminated Product Net Revenues for such Terminated Product by the
Continuing Party and its Affiliates (but not by its licensees or sublicensees) as follows: 
  

			
	  
 Calendar
Year Net Revenues for
           Terminated Product
	  	Royalty Rate
	 	 
	Less than or equal to [*]	  	[*]
	 	 
	Greater than [*] and less than or
equal to
[*]	  	[*]
	 	 
	Greater than [*]	  	[*]

 Additionally, [*], the Continuing Party will pay to the Terminating Party [*] of any and
all Sublicensing Revenues received by the Continuing Party and/or its Affiliates. 
 Additionally, if Partner is
the Continuing Party, Partner will pay to Amgen an additional royalty equal to the applicable Terminated Product 

  
 70 

 
Inventorship Margin on Terminated Product Net Revenues by Partner, its Affiliates and sublicensees. 
 Such royalty will be payable quarterly within thirty (30) days of the end of the calendar quarter for which such royalties are owed. Each royalty payment will be accompanied by a report setting forth
Partner’s calculation of Net Revenues and royalties owed for the applicable quarter. For such purposes, “Terminated Product Net Revenues” means “Net Revenues,” and “Terminated Product Inventorship
Margin” will mean the “Inventorship Margin,” but for such purposes substituting in such definitions (including in each definition referenced in such definitions) a reference to “Terminated Product” for each
reference to “Product;” and Sections 7.4 (Calculation of Net Revenues) and 8.3 (Currency) through 8.7 (Late Payment) (inclusive) will apply with respect to such royalty payments, mutatis mutandis. 

 

	 	14.6.2.	 Termination of Agreement in Entirety. In the event (i) this Agreement is terminated by Partner in its entirety under Section 14.2
(Termination for Convenience) or is terminated in its entirety under Sections 14.3 (Termination for Breach) through 14.5 (Termination for Challenge) (inclusive), or (ii) if as of the Termination Effective Date with respect to a Terminated
Product, there are no other Products then being developed or commercialized under this Agreement, and Partner is not then developing or commercializing a Terminated Product as the Continuing Party under Section 14.6.1 (Product by Product
Termination) above; then in either such case, the Agreement will terminate in whole, and all provisions of this Agreement will terminate as of the effective date of such termination, except as expressly set forth in Sections 14.6.1 (Product by
Product Termination) and 14.6.3 (Survival) below. 

  

	 	14.6.3.	 Survival. Articles 1 (Definitions), 7 (Profit/Expense Sharing) (with respect to periods prior to termination), 8 (Payments) (with respect to
periods prior to termination), 9 (Distracting Products) (only with respect to such continuing periods as expressly referenced in such Article), 13 (Indemnification and Insurance) (with respect to periods prior to termination), and 15 (Miscellaneous)
and Sections 2.2 (Ex-Territory Activities), 3.4 (Product Complaints, Recalls and Returns), 5.8 (Detailing Reports and Audit Rights) (with respect to periods prior to termination), 5.9 (Competing Products) (with respect to periods prior to
termination), 10.1 (Invention Ownership), 10.3 (Joint Ownership), 10.4 (License Grant by Amgen) (only with respect to the transition period referenced in clause (vii) of Section 14.6.1.3 (Transition)), 10.5 (License Grant by Partner), 10.8
(Enforcement) (with respect to enforcement against activities that took place prior to or termination), 10.9 (Patent Term Extensions) (with respect to periods prior to termination), 10.10.3 (Housemark Licenses) (with respect to the transition period
referenced in clause (vii) of Section 14.6.1.3 (Transition) and the sell-off period referenced therein), 11.1 (Confidentiality; Exceptions), 11.2 (Authorized Disclosure), 11.3 (Confidential Treatment of Terms and Conditions), 11.5 (Prior
Agreement), and this 14.6 (Effects of Termination) (with all Products deemed Terminated Products and Amgen being the 

  
 71 

	 	 
Continuing Party for all Terminated Products) will survive termination of this Agreement for any reason. Except as otherwise provided in this Section 14.6 (Effects of Termination), all
rights and obligations of the Parties under this Agreement will terminate upon termination of this Agreement for any reason. 

  

	 	14.6.4.	 No Limitation of Rights. The rights provided in this Article 14 (Term and Termination) will be in addition and without prejudice to any other
rights which the Parties may have with respect to any default or breach of the provisions of this Agreement. Termination is not the sole remedy under this Agreement and, whether or not termination is effected, all other remedies at equity or law
will remain available to the Parties except as expressly agreed otherwise herein. 

 15. MISCELLANEOUS

  

	15.1.	 Affiliates. Each Party will have the right to exercise its rights and perform its obligations hereunder through its Affiliates (including by
licensing rights hereunder where such rights are held in the name of any such Affiliate); provided, that such Party will be responsible for its Affiliates’ performance hereunder. 

 

	15.2.	 Assignment. Neither this Agreement nor any rights or obligations hereunder may be assigned or otherwise transferred (whether by operation of
Applicable Law, general succession or otherwise) by either Party without the prior written consent of the other Party; provided, that either Party may assign this Agreement, or rights and obligations hereunder, without prior written consent
to any Affiliate (as long as such entity remains an Affiliate of the relevant Party), or in connection with the transfer or sale of all or substantially all of the business to which this Agreement relates. Any assignment not in accordance with this
Agreement will be void ab initio. Subject to the foregoing, the rights and obligations of the Parties under this Agreement will be binding upon and inure to the benefit of the successors and permitted assigns of the Parties.

  

	15.3.	 Choice of Law; Jurisdiction. This Agreement will be governed by, and enforced and construed in accordance with, the laws of the State of New
York without regard to its conflicts of law provisions, except as to any issue which depends upon the validity, scope or enforceability of any Patent, which issue will be determined in accordance with the laws of the country in which such patent was
issued. Each of the Parties hereby irrevocably and unconditionally consents to submit to the exclusive jurisdiction of the state and federal courts of the State of New York for any matter arising out of or relating to this Agreement and the
transactions contemplated hereby, and agrees not to commence any litigation relating thereto except in such courts. Each of the Parties hereby irrevocably and unconditionally waives any objection to the laying of venue of any matter arising out of
this Agreement or the transactions contemplated hereby in the state and federal courts of the State of New York and hereby further irrevocably and unconditionally waives and agrees not to plead or claim in any such court that any such matter brought
in any such court has been brought in an inconvenient forum. The Parties agree that a final judgment in any such matter will be conclusive and may be enforced in other jurisdictions by suits on the judgment or in any other manner provided by law.
Any proceeding brought by either Party under this Agreement will be exclusively conducted 

  
 72 

	 	 
in the English language. The United Nations Convention for the International Sale of Goods will not apply to the transactions contemplated herein. 

 

	15.4.	 Construction. The definitions of the terms herein will apply equally to the singular and plural forms of the terms defined. Whenever the
context may require, any pronoun will include the corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” will be deemed to be followed by the phrase “without
limitation”. The word “or” is used in the inclusive sense (and/or). The Parties each acknowledge that they have had the advice of counsel with respect to this Agreement, that this Agreement has been jointly drafted, and that no rule
of strict construction will be applied in the interpretation hereof. Unless the context requires otherwise: (i) any definition of or reference to any agreement, instrument or other document herein will be construed as referring to such
agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein); (ii) any reference to any
Applicable Law herein will be construed as referring to such Applicable Law as from time to time enacted, repealed or amended; (iii) any reference herein to any person will be construed to include the person’s permitted successors and
assigns; (iv) the words “herein”, “hereof” and “hereunder”, and words of similar import, will be construed to refer to this Agreement in its entirety and not to any particular provision hereof; and (v) all
references herein to Articles, Sections, or Schedules, unless otherwise specifically provided, will be construed to refer to Articles, Sections or Schedules of this Agreement. This Agreement has been executed in English, and the English version of
this Agreement will control. 

  

	15.5.	 Counterparts. This Agreement may be executed in counterparts with the same effect as if both Parties had signed the same document. All such
counterparts will be deemed an original, will be construed together and will constitute one and the same instrument. Signature pages of this Agreement may be exchanged by facsimile or other electronic means without affecting the validity thereof.

  

	15.6.	 Entire Agreement. This Agreement, including the attached Schedules, constitutes the entire agreement between the Parties as to the subject
matter of this Agreement, and supersedes and merges all prior or contemporaneous negotiations, representations, agreements and understandings regarding the same. 

 

	15.7.	 Force Majeure. Neither Party will be liable for delay or failure in the performance of any of its obligations hereunder (other than the
payment of money) to the extent such delay or failure is due to causes beyond its reasonable control, including acts of God, fires, floods, pandemics, earthquakes, labor strikes, acts of war, terrorism or civil unrest (“Force
Majeure”); provided, that the affected Party promptly notifies the other Party in writing (and continues to provide monthly status updates to the other Party for the duration of the effect); and provided, further that the
affected Party uses its Commercially Reasonable Efforts to avoid or remove such causes of non-performance and to mitigate the effect of such occurrence, and will continue performance with reasonable dispatch whenever such causes are removed.

  
 73 

	15.8.	 Further Assurances. Each Party agrees to do and perform all such further acts and things and will execute and deliver such other agreements,
certificates, instruments and documents necessary or that the other Party may reasonably request in order to carry out the intent and accomplish the purposes of this Agreement and to evidence, perfect or otherwise confirm its rights hereunder.

  

	15.9.	 Headings. Headings and captions are for convenience only and are not to be used in the interpretation of this Agreement.

  

	15.10.	 No Set-Off. Except as expressly set forth in Section 7.2.9 (True-Up), Section 8.6.1 (Withholding) or Section 8.6.2 (Indirect
Taxes), no Party will have the right to deduct from amounts otherwise payable hereunder any amounts payable to such Party (or its Affiliates) from the other Party (or its Affiliates), whether pursuant to this Agreement or otherwise.

  

	15.11.	 Notices. Any notice required or permitted to be given by this Agreement will be in writing, in English, and will be delivered by hand or
overnight courier with tracking capabilities or mailed postage prepaid by registered or certified mail addressed as set forth below unless changed by notice so given: 

 

			
	If to Amgen:	    	 Amgen Inc.
 One Amgen Center
Drive

		    	Thousand Oaks, California 91320-1799
		    	Attention: Corporate Secretary
		    	Telephone: 805-447-1000
		    	Facsimile: [*]
		
	If to Partner:	    	AstraZeneca Collaboration Ventures, LLC
		    	One MedImmune Way
		    	Gaithersburg, Maryland 20878
		    	Attention: President
		    	Telephone: [*]
		    	Facsimile: [*]
		
		    	With a copy to the Secretary of AstraZeneca Collaboration Ventures, LLC at the above address.

 Any such notice will be deemed given on the date delivered. A Party may add, delete (so
long as at least one person is remaining), or change the person or address to which notices should be sent at any time upon written notice delivered to the other Party in accordance with this Section 15.11 (Notices). 

 

	15.12.	 Relationship of the Parties. Each Party is an independent contractor under this Agreement. Nothing contained herein will be deemed
to create an employment, agency, joint venture or partnership relationship between the Parties or any of their agents or employees, or any other legal arrangement that would impose liability upon one Party for the act or failure to act of the other
Party. The Parties will operate their own businesses separately and independently and they will hold themselves out as, act as, and constitute independent 

  
 74 

	 	 
contractors in all respects and not as principal and agent, partners or joint venturers. Neither party will have any express or implied power to enter into any contracts or commitments or to
incur any liabilities in the name of, or on behalf of, the other Party, or to bind the other Party in any respect whatsoever.

  

	15.13.	 Severability. To the fullest extent permitted by Applicable Law, the Parties waive any provision of Applicable Law that would render any
provision in this Agreement invalid, illegal or unenforceable in any respect. If any provision of this Agreement is held to be invalid, illegal or unenforceable, in any respect or to any extent, then in such respect and to such extent such provision
will be given no effect by the Parties and will not form part of this Agreement. To the fullest extent permitted by Applicable Law, all other provisions of this Agreement will remain in full force and effect and the Parties will use their
commercially reasonable efforts to negotiate a provision in replacement of the provision held invalid, illegal or unenforceable that is consistent with Applicable Law and achieves, as nearly as possible, the original intention of the Parties.

  

	15.14.	 Third Party Beneficiaries. Except as expressly provided with respect to Amgen Indemnitees or Partner Indemnities in Article 13
(Indemnification and Insurance), there are no Third Party beneficiaries intended hereunder and no Third Party will have any right or obligation hereunder. 

 

	15.15.	 Waivers and Modifications. The failure of any Party to insist on the performance of any obligation hereunder will not be deemed to be a
waiver of such obligation. Waiver of any breach of any provision hereof will not be deemed to be a waiver of any other breach of such provision or any other provision on such occasion or any other occasion. No waiver, modification, release or
amendment of any right or obligation under or provision of this Agreement will be valid or effective unless in writing and signed by all Parties hereto. 

 

	15.16.	[*]. 

 ********* 

(Signature page follows) 

  
 75 

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the Effective Date.

  

									
	ASTRAZENECA COLLABORATION VENTURES, LLC	 		 	 AMGEN INC.

 

					
	By:	 	 /s/ Peter Greenleaf
	 		 	By:	 	 /s/ David J. Scott

									
					
	Name:	 	 Peter Greenleaf
	 		 	Name:	 	 David J. Scott

									
					
	Title:	 	 President
	 		 	Title:	 	 SVP, General Counsel & Secretary

				
	ASTRAZENECA PHARMACEUTICALS LP	 		 		 	
					
	By:	 	 /s/ Ann Booth Barbarin
	 		 		 	

									
					
	Name:	 	 Ann Booth Barbarin
	 		 		 	

									
					
	Title:	 	 Assistant Secretary
	 		 		 	

  
 S-1

 Schedule 
 AMG827 Territory 
  

					
	 Column
1
  
 European Countries

 
 Albania
 Andorra
 Armenia
 Austria
 Azerbaijan
 Belarus
 Belgium
 Bosnia-Herzg.
 Bulgaria
 Croatia
 Czech Republic
 Denmark
 Estonia
 Finland
 France
 Georgia
 Germany
 Greece
 Hungary
 Iceland
 Ireland
 Italy
 Latvia
 Lithuania
 Liechtenstein
 Luxembourg
 Macedonia
 Malta
 Moldova
 Monaco
 Netherlands
 Norway
 Poland
 Portugal
 Romania
 Russia
 San Marino
 Serbia and Montenegro
 Slovakia
 Slovenia
 Sweden
 Switzerland
 Spain
	 	 Column 2

 
 Central and South American

Countries
  
 Antigua and Barbuda
 Argentina
 Bahamas
 Barbados
 Belize
 Bolivia
 Brazil
 Chile
 Colombia
 Costa Rica
 Cuba
 Dominica
 Dominican Republic
 Ecuador
 El Salvador
 French Guiana
 Grenada
 Guatemala
 Guyana
 Honduras
 Jamaica
 Nicaragua
 Panama
 Paraguay
 Peru
 Saint Kitts and Nevis
 Saint Lucia
 Saint Vincent and the Grenadines

Suriname
 Trinidad and Tobago

Uruguay
 Venezuela
	 	 Column
3
  
 African and Middle East

Countries
  
 Algeria
 Angola
 Bahrain
 Angola
 Benin
 Botswana
 Burkina Faso
 Cameroon
 Central African Republic
 Congo (Democratic Republic of)

Congo (Republic of the)
 Cote D’Ivoire/Ivory
Coast
 Cyprus
 Djibouti

Egypt
 Eritrea

Ethiopia
 Gabon

Gambia
 Ghana

Gibraltar
 Greenland

Iran
 Iraq

Israel
 Jordan

Kazakhstan
 Kenya

Kuwait
 Kyrgyzstan

Lesotho
 Lebanon

Liberia
 Libya

Madagascar
 Malawi

Mauritania
 Mauritius

Morocco
 Mozambique

Namibia

					
	
Ukraine
 United Kingdom

Vatican City
	 	 	 	
Niger
 Nigeria

Oman
 Qatar

Rwanda
 Saudi Arabia

Senegal
 Seychelles

Sierra Leone
 Somalia

South Africa
 Sudan

Swaziland
 Syria

Tajikistan
 Tanzania

Tunisia
 Turkey

Turkmenistan
 Uganda

United Arab Emirates
 Uzbekistan

Yemen
 Zambia

Zimbabwe
  

 Schedule 
 Amgen Distribution Countries 
  

							
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 Schedule 
 Commercial Allocation 
 AMG827- 

Respiratory- 

Partner will have the sole right to Detail Products in the Respiratory market in the Collaboration Territory. 

Rheumatology- 
 Amgen will have the sole right to Detail Products in the Rheumatology market in North America, Europe, Australia and New Zealand. 
 For the Rheumatology market in all other countries in the Collaboration Territory, the Parties shall enter into discussions regarding the allocation of Details beginning [*] prior to the anticipated first
commercial launch of AMG827 for a Rheumatology indication. The JSC shall agree upon the allocation of Details between the Parties taking into account all relevant factors [*]; provided, that if the JSC is unable to agree upon the allocation
of Details in any country, then such matter shall be escalated to the CRC; provided, further, that if the CRC is unable to agree upon the allocation of Details in any country, [*]. To the extent less than one hundred percent (100%) of
the Details in any such country have been allocated to the Parties, the Parties shall [*]. If the Parties in the aggregate elect to Detail in excess of one hundred percent (100%) of the Details in any such country, then each Party will be
entitled to only [*]. 
 Dermatology- 
 Amgen will have the sole right to Detail Products in the Dermatology market in North America. 
 For the Dermatology market in all other countries in the Collaboration Territory, Partner will have the sole right to Detail Products, provided, that, to the extent Amgen has or develops a commercial
capability to Detail Products consistent with the Brand Plan in the Dermatology market in any such country, so that in such country Amgen would have the capability to provide [*] percent ([*]%) of the Details in that country, Amgen will have the
right to provide [*] percent ([*]%) of such Details in such country, provided that Amgen shall not have the right to provide Details in countries which collectively represent in excess of [*] percent ([*]%) of [*] of all countries in the
Collaboration Territory [*]. If Amgen determines that it wishes to build a commercial capability in a country (without necessarily having sufficient capability to provide [*] percent ([*]%) of the Details in that country) the Parties will discuss in
good faith allocation of Details in such country to determine what is in the best interests of the Product in that country according to the then current Brand Plan. 

 Additional Indications- 
 For all market segments other than Respiratory, Rheumatology and Dermatology, the Parties shall enter into discussions regarding the allocation of Details beginning [*] prior to the anticipated first
commercial launch of AMG827 for such market segment. The JSC shall agree upon the allocation of Details between the Parties taking into account all relevant factors [*]; provided, that if the JSC is unable to agree upon the allocation of
Details in any country, then such matter shall be escalated to the CRC; provided, further, that if the CRC is unable to agree upon the allocation of Details in any country, [*]. To the extent less than one hundred percent (100%) of the
Details in any such country have been allocated to the Parties, the Parties shall [*]. If the Parties in the aggregate elect to Detail in excess of one hundred percent (100%) of the Details in any such country, then each Party will be entitled
to only [*]. 
 Definitions- 
 “Dermatology” means the branch of medicine dealing with the skin and its diseases or disorders, including psoriasis and atopic dermatitis. 

“Respiratory” means the branch of medicine dealing with inflammatory respiratory diseases or disorders and obstructive
respiratory diseases or disorders, including asthma and chronic obstructive pulmonary disease (COPD). 

“Rheumatology” means the branch of medicine dealing with rheumatic diseases or disorders, including rheumatoid arthritis,
systemic lupus erythematosus (SCE), psoriatic arthritis, and ankylosing spondylitis. 
 All Other Products- 

For all other Products, the Parties shall, on a market segment basis, enter into discussions regarding the allocation of Details for a
Product beginning [*] prior to the anticipated first commercial launch of such Product for such market segment. The JSC shall agree upon the allocation of Details between for such Product in such market segment the Parties taking into account all
relevant factors ([*]); provided, that if the JSC is unable to agree upon the allocation of Details in any country, then such matter shall be escalated to the CRC; provided, further, that if the CRC is unable to agree upon the
allocation of Details in any country, [*]. To the extent less than one hundred percent (100%) of the Details in any such country have been allocated to the Parties, the Parties shall [*]. If the Parties in the aggregate elect to Detail in
excess of one hundred percent (100%) of the Details in any such country, then each Party will be entitled to only [*]. 

 Schedule 
 Completed Clinical Trials 
 AMG 139 

	 	—	 	 Ph 1a FIH single ascending dose study (20080767) 

 AMG 157 

	 	—	 	 Ph 1a FIH single ascending dose study (20070620) 

	 	—	 	 Ph 1b multiple ascending dose study (20080390) 

 AMG 557 

	 	—	 	 Ph 1a FIH single ascending dose study in SLE subjects (2006132) 

	 	—	 	 Ph 1b MAD in SLE subjects (2007169)

 AMG 827 
  

	 	—	 	 Ph1 device preference study in HV (20110106) 

	 	—	 	 Ph 1a FIH single ascending dose study (20060279) 

	 	—	 	 Ph 1b multiple ascending dose study in RA (20070264) 

	 	—	 	 Ph 2 multiple dose, dose ranging study in RA (20090061) 

	 	—	 	 Ph 2 open label extension study in RA (20090402) 

	 	—	 	 Ph 2 multiple dose, dose ranging study in psoriasis (20090062) 

	 	—	 	 Ph 2 multiple dose, dose ranging study in CD (20090072) 

	 	—	 	 Ph 2 open label extension study in CD (201000008) 

	 	—	 	 Ph 2 multiple dose, dose ranging study in asthma (20090203) 

 Schedule 
 [*] Designated Endpoints [*] 
 All of the following criteria must be met
for a go decision to commence a [*] Trial. 
  

	—	 	 [*]: A statistically significant [*] and clinically significant ([*]) change in [*] from [*] at [*] for [*] and the [*] performs similarly to or better
than the [*]. 

  

	—	 	 [*]: A trend in [*] of [*] from [*] for [*] and the [*]. [*] are defined as [*] leading to [*] for [*]. The [*] in [*] will be [*] with the [*]. If the
[*], then [*] and the [*]. 

  

	—	 	 [*]: There are no [*] that [*]. 

 Schedule 
 Development/Commercial Lead 
  

			
	  

Amgen
  
	  	 Partner

 

	
AMG827
	  	AMG139
	
AMG557
	  	AMG157
	 	  	AMG181

 [*] - 
  

	1	 Specifically with regard to AMG827 at the global level, the Parties will work closely through the JPT on the commercial strategy for the Respiratory
market for AMG827 with Amgen taking the primary responsibility for [*]. 

  

	2	 [*]. 

  

	3	 The Parties will cooperate to ensure that [*] is made available to the JPT at both the global and regional level. 

 

	4	 This arrangement will be noted in the press release and other approved communications as “[*]” or with words of similar import.

 Schedule 
 Distracting Product 
  
  

					
	 	 	 
	Product	  	Product Target	  	Distracting Target*
	 	 	 
	
AMG 139
  
	  	 [*]

 
	  	 [*]

 

	 	 	 
	
AMG 157
  
	  	 [*]

 
	  	 [*]

 

	 	 	 
	
AMG 181
  
	  	 [*]

 
	  	 [*]

 

	 	 	 
	
AMG 557
  
	  	 [*]

 
	  	 [*]

 

	 	 	 
	
AMG 827
  
	  	 [*]

 
	  	 [*]

 

 *Distracting Target includes (i) any [*]; (ii) any [*]; (iii) any [*]; (iv) any [*]; and (v) any
[*]. For avoidance of doubt, the Distracting Product Schedule lists [*]. 

 Schedule 
 Invoice 

 Amgen Inc. 

Invoice Template 
 2nd Quarter 2012 - Example Period

  

																																			
	 	 	A	 	 	B	 	 	C = A + B	 	 	 	 	D	 	 	E	 	 	F = D + E	 	 	 	 	G = A - F	 	 	 <<< Amount Billed or Reimbursed to Partner

	  	 	Total Quarterly Spend*	 	 	 	 	Amgen’s Share of...**	 	 	 	 	Amount due	 	 
	Product	 	Amgen	 	 	Partner	 	 	Total	 	 	 	 	Amgen’s Spend	 	 	Partner’s Spend	 	 	Total Spend	 	 	 	 	(From)/To Amgen	 	 
	 AMG 139  
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 
	 AMG 157  
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 
	 AMG 181  
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 
	 AMG 557  
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 
	 AMG 827  
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 
	 Total
	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 

 Notes 
 * Total spend
derived from Column K on Page 2 and Column C on Page 3 
 ** Amgen’s Share of Total Spend derived from Column L on Page 2 and Column D on Page 3

 Amgen Inc. 

Invoice Template 
 2nd Quarter 2012 - Example Period

 Step 1: Calculation of Total AMGEN Cost less Amount Reimbursed by 3rd Party 

 

																																																											
	 	 	 	 	A	 	 	B	 	 	C = A + B	 	 	D = C x 35%	 	 	E = C - D	 	 	 	 	F	 	 	G	 	 	H = F + G	 	 	I = H x 70%	 	 	J = H - I	 	 	 	 	K = C + H	 	 	L = D + I	 	 	M = E + J	 
	  	 	  	 	Total Costs Excluding AMG827 Ph2b
Asthma Study	 	 	 	 	Costs for AMG827 Ph2b Asthma
Study	 	 	 	 	Total Amgen Costs	 
	  	 	  	 	Gross Spend	 	 	 Amgen

Share
	 	 	
Partner

Share
	 	 	 	 	Gross Spend	 	 	 Amgen

Share
	 	 	
Partner

Share
	 	 	 	 	 	 	 	 	 	 	 	 
	Function	 	Product	 	OSE	 	 	FTE	 	 	Total	 	 	35%	 	 	65%	 	 	 	 	OSE	 	 	FTE	 	 	Total	 	 	70%	 	 	30%	 	 	 	 	Total	 	 	 Amgen

Share
	 	 	 Partner

Share
	 
	
R&D
	 	AMG 139	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 157	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 181	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 557	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 827	 	 	 	 	 	 	 	 	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	 	 	 	 	 	 	 	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	Sub-Total R&D	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	
Operations
	 	AMG 139	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 157	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 181	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 557	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 827	 	 	 	 	 	 	 	 	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	 	 	 	 	 	 	 	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	Sub-Total Ops	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	
Commercial
	 	AMG 139	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 157	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 181	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 557	 				 				 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 827	 	 	 	 	 	 	 	 	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	Sub-Total Comm’l  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 Total
	 	AMG 139	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 157	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 181	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 557	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 				 				 			 	 			 	 			 	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	AMG 827	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  
	 	Grand Total	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 	$	-  	  	 		 	$	-  	  	 	$	-  	  	 	$	-  	  

 Notes 
 1. Page
reflects Total Costs Incurred by/Reimbursed to AMGEN only 
 2. The values in the “Total” Row will be used for the following
purposes on Page 1 
 - Determine the combined (Amgen + Partner) Total Cost of all programs in a quarter 

- Deduct the actual expenses incurred/paid by Amgen from Amgen’s share of quarterly expenses 

 Amgen Inc. 

Invoice Template 
 2nd Quarter 2012 - Example Period

 Costs Incurred by Partner 
  

													
	  	 	  	 	A	 	B	 	C = B+A	 	D = 35% x C	 	E = C-D
	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	    Amgen Share    	 	Partner Share
	Function	 	Product	 	    FTE    	 	    OSE    	 	    Total Costs    	 	35%	 	65%
	R&D	 	AMG 139	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 157	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 181	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 557	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 827	 	 	 	 	 	$                -	 	$                      - 
 	 	$                -  
	 	 	Total	 	$          -    	 	$          -    	 	$                -	 	$                      
-  	 	$                -  
	Operations	 	AMG 139	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 157	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 181	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 557	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 827	 	 	 	 	 	$                -	 	$                      - 
 	 	$                -  
	 	 	Total	 	$          -    	 	$          -    	 	$                -	 	$                      
-  	 	$                -  
	Commercial    	 	AMG 139	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 157	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 181	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 557	 		 		 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 827	 	 	 	 	 	$                -	 	$                      - 
 	 	$                -  
	 	 	Total	 	$          -    	 	$          -    	 	$                -	 	$                      
-  	 	$                -  
	Total	 	AMG 139	 	$          -    	 	$          -    	 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 157	 	$          -    	 	$          -    	 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 181	 	$          -    	 	$          -    	 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 557	 	$          -    	 	$          -    	 	$                -	 	$                      -  	 	$                -  
	 	 	AMG 827	 	$          -    	 	$          -    	 	$                -	 	$                      - 
 	 	$                -  
	 	 	Total	 	$          -    	 	$          -    	 	$         
       -	 	$         
             -  	 	$      
          -  

 Notes 
 1. On this tab, Amgen
will capture the quarterly spend incurred by partner for aggregation purposes 
 2. Table above is a placeholder/stand-in which will be replaced by
the quarterly actual cost summary provided by partner 
 3. The values in the “Total” Row will be used for the following purposes on Page
1 
 - Determine the combined (Amgen + Partner) Total Cost of all programs in a quarter 
 - Deduct the actual expenses incurred/paid by partner from the partner’s share of quarterly expenses 

 Schedule 
 Press Release 

  
 

 
 News Release 
  

 
 AMGEN AND ASTRAZENECA ANNOUNCE
COLLABORATION 
 TO JOINTLY DEVELOP AND COMMERCIALIZE CLINICAL- 

STAGE INFLAMMATION PORTFOLIO 
 Collaboration Comprises Five Monoclonal Antibodies 
 Brodalumab (AMG 827)
Phase 3 Trial Planned in 2012 
 THOUSAND OAKS, Calif. and LONDON (April 2, 2012)—Amgen (NASDAQ:AMGN) and AstraZeneca Plc, today
announced an agreement to jointly develop and commercialize five monoclonal antibodies from Amgen’s clinical inflammation portfolio (AMG 139, AMG 157, AMG 181, AMG 557 and brodalumab (AMG 827)). 

The companies believe all the molecules have novel profiles and offer the potential to deliver important treatments across multiple indications in
inflammatory diseases. The collaboration will provide Amgen with additional resources to optimally progress its portfolio, and Amgen will benefit from the strong respiratory, inflammation and asthma development expertise of MedImmune,
AstraZeneca’s biologics arm. The collaboration will also capitalize on AstraZeneca’s global commercial reach in respiratory and gastrointestinal diseases. The agreement does not include certain territories previously partnered by Amgen for
brodalumab with Kyowa Hakko Kirin and AMG 557 with Takeda. 
 Under the terms of the agreement, AstraZeneca will make a one-time $50 million
upfront payment and the companies will share both costs and profits. Based on current plans, approximately 65 percent of costs for the 2012-2014 period will be funded by AstraZeneca. Thereafter, the companies will split costs equally. Amgen will
book sales globally and will retain a low single-digit royalty for brodalumab and a mid single-digit royalty for the rest of the portfolio, after which the companies will share profits equally. 

AstraZeneca will lead the development and commercialization strategy of AMG 139, AMG 157 and AMG 181, while Amgen will lead the development and
commercialization strategy of brodalumab and AMG 557. Each development and commercialization lead will be under the oversight of joint governing bodies. For brodalumab, commercial promotion will be split. Amgen will promote in dermatology
indications in the United States (U.S.) and Canada, and in rheumatology indications in U.S., Canada and Europe. AstraZeneca will promote in respiratory and, initially, in dermatology indications of brodalumab across all territories outside the U.S.,
Canada and those markets where Amgen has existing partnerships. Allocation of promotional rights for other territories, indications and molecules will be agreed later between the companies. 
 “We are delighted to join forces with Amgen in developing and commercializing these novel clinical-stage assets that add value to our pipeline and build on our expertise in biologics. This creative
collaboration will make the most of both companies’ respective capabilities, including AstraZeneca’s extensive global reach, to help bring these potentially innovative treatment options for a variety of respiratory and inflammatory
diseases to patients around the world,” said David Brennan, Chief Executive Officer, AstraZeneca. 
 “We are very excited at the
prospect of collaborating with a well-respected organization like AstraZeneca to advance our inflammation pipeline,” said Kevin Sharer, Chairman and CEO at Amgen. “We believe this collaboration has the potential to bring more therapies to
patients sooner, across more geographic areas. We are impressed with AstraZeneca’s extensive experience in developing and launching products in the respiratory and gastroenterology areas, and believe this collaboration is an opportunity to work
with a partner that has leading regulatory and commercial expertise in inflammation indications.” 
 -ENDS- 

 NOTES TO EDITORS 
 About the inflammation portfolio included in the agreement 
 Under the agreement, the
companies will jointly develop and commercialize the following five assets from Amgen’s clinical-stage portfolio: 
  

	 	•	 	 Brodalumab (AMG 827) is a human monoclonal antibody that binds to and blocks signaling via the IL-17 receptor. Brodalumab is being investigated
for psoriasis (completed Phase 2 and planned Phase 3), psoriatic arthritis (Phase 2) and asthma (Phase 2). 

  

	 	•	 	 AMG 139 is a human monoclonal antibody. AMG 139 is being investigated in Phase 1b for Crohn’s disease. 

 

	 	•	 	 AMG 181 is a human monoclonal antibody. AMG 181 is being investigated in Phase 1a and Phase 1b for ulcerative colitis and Crohn’s disease.

  

	 	•	 	 AMG 557 is a human monoclonal antibody that binds to B7-related protein 1 (B7RP-1). AMG 557 is being investigated in Phase 1b for autoimmune
diseases such as systemic lupus erythematosus. 

  

	 	•	 	 AMG 157 is a human monoclonal antibody that blocks interaction of thymic stromal lymphopoietin (TSLP) with the TSLP receptor. AMG 157 is being
investigated in Phase 1b for asthma. 

 About Amgen 
 Amgen discovers, develops, manufactures and delivers innovative human therapeutics. A biotechnology pioneer since 1980, Amgen was one of the first companies to realize the new science’s promise by
bringing safe and effective medicines from lab, to manufacturing plant, to patient. Amgen therapeutics have changed the practice of medicine, helping millions of people around the world in the fight against cancer, kidney disease, rheumatoid
arthritis, bone disease and other serious illnesses. With a deep and broad pipeline of potential new medicines, Amgen remains committed to advancing science to dramatically improve people’s lives. To learn more about our pioneering science and
our vital medicines, visit www.amgen.com. Follow us on www.twitter.com/amgen. 
 About AstraZeneca 

AstraZeneca is a global, innovation-driven biopharmaceutical business with a primary focus on the discovery, development and commercialization of
prescription medicines for gastrointestinal, cardiovascular, neuroscience, respiratory and inflammation, oncology and infectious disease. AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients
worldwide. For more information please visit: www.astrazeneca.com. 
 Amgen Forward Looking Statements 

This news release contains forward-looking statements that are based on Amgen’s current expectations and beliefs and are subject to a number of
risks, uncertainties and assumptions that could cause actual results to differ materially from those described. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including
estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement
activities and outcomes and other such estimates and results. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission (SEC)
reports filed by Amgen, including Amgen’s most recent annual report on Form 10-K and most recent periodic reports on Form 10-Q and Form 8-K. Please refer to Amgen’s most recent Forms 10-K, 10-Q and 8-K for additional information on
the uncertainties and risk factors related to Amgen’s business. Unless otherwise noted, Amgen is providing this information as of April 2, 2012 and expressly disclaims any duty to update information contained in this news release.

 No forward-looking statement can be guaranteed and actual results may differ materially from those Amgen projects. Discovery or
identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or
development of a new indication for an existing product will be successful and become a commercial product. Further, preclinical results do not guarantee safe and effective performance of product candidates in humans. The complexity of the
human body cannot be perfectly, or sometimes, even adequately modeled by computer or cell culture systems or animal models. The length of time that it takes for Amgen to complete clinical trials and obtain regulatory approval for product
marketing has in the past varied and Amgen expects 

 
similar variability in the future. Amgen develops product candidates internally and through licensing collaborations, partnerships and joint ventures. Product candidates that are derived
from relationships may be subject to disputes between the parties or may prove to be not as effective or as safe as Amgen may have believed at the time of entering into such relationship. Also, Amgen or others could identify safety, side effects or
manufacturing problems with Amgen’s products after they are on the market. Amgen’s business may be impacted by government investigations, litigation and products liability claims. Amgen depends on third parties for a significant
portion of its manufacturing capacity for the supply of certain of its current and future products and limits on supply may constrain sales of certain of its current products and product candidate development. 

In addition, sales of Amgen’s products are affected by the reimbursement policies imposed by third-party payors, including governments, private
insurance plans and managed care providers and may be affected by regulatory, clinical and guideline developments and domestic and international trends toward managed care and healthcare cost containment as well as U.S. legislation affecting
pharmaceutical pricing and reimbursement. Government and others’ regulations and reimbursement policies may affect the development, usage and pricing of Amgen’s products. In addition, Amgen competes with other companies with
respect to some of its marketed products as well as for the discovery and development of new products. Amgen believes that some of its newer products, product candidates or new indications for existing products, may face competition when and as
they are approved and marketed. Amgen’s products may compete against products that have lower prices, established reimbursement, superior performance, are easier to administer, or that are otherwise competitive with its products. In
addition, while Amgen routinely obtains patents for its products and technology, the protection offered by its patents and patent applications may be challenged, invalidated or circumvented by its competitors and there can be no guarantee of
Amgen’s ability to obtain or maintain patent protection for its products or product candidates. Amgen cannot guarantee that it will be able to produce commercially successful products or maintain the commercial success of its existing
products. Amgen’s stock price may be affected by actual or perceived market opportunity, competitive position, and success or failure of its products or product candidates. Further, the discovery of significant problems with a product
similar to one of Amgen’s products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on Amgen’s business and results of operations. 

The scientific information discussed in this news release related to Amgen’s product candidates is preliminary and investigative. Such product
candidates are not approved by the U.S. Food and Drug Administration (FDA), and no conclusions can or should be drawn regarding the safety or effectiveness of the product candidates. Only the FDA can determine whether the product candidates are
safe and effective for the use(s) being investigated. Only the FDA can determine whether the products are safe and effective for these uses. Healthcare professionals should refer to and rely upon the FDA-approved labeling for the
products, and not the information discussed in this news release. 
 CONTACT: Amgen, Thousand Oaks 

Christine Regan, 805-447-5476 (media) 
 Arvind
Sood, 805-447-1060 (investors) 
  
 ASTRA ZENECA CONTACTS 

 
  

					
	Media Enquiries	  		  	
			
	Esra Erkal-Paler	  	+44 20 7604 8030	  	
			
	Sarah Lindgreen	  	+44 20 7604 8033	  	
		
	Investor Enquiries UK	  	

					
			
	James Ward-Lilley	  	+44 20 7604 8122 mob: +44 7785 432613	  	
			
	Karl Hård	  	+44 20 7604 8123 mob: +44 7789 654364	  	
			
	Nicklas Westerholm	  	+44 20 7604 8124 mob: +44 7585 404950	  	
		
	Investor Enquiries US	  	
			
	Ed Seage	  	+1 302 886 4065 mob: +1 302 373 1361	  	
			
	Jorgen Winroth	  	+1 212 579 0506 mob: +1 917 612 4043	  	

 Schedule 
 Products 
  

	
	  

Product
  

	  

AMG 139
  

	  

AMG 157
  

	  

AMG 181
  

	  

AMG 557
  

	  
 AMG 827
  

 Schedule 
 Profit (Loss) Example 
 This schedule provides examples of the calculation
of the Inventorship Margin and the calculation of the Profit (Loss) True-Up pursuant to Section 7.2.8 (Calculation of Profit (or Loss)). 

I.        Inventorship Margin. Assume for purposes of this example that Net Revenues are as
follows: 
  

									
	  	 	 Q1 2017
	 	 Q2 2017
	 	 Q3 2017
	 	
Q4 2017

	 Net Revenues

(excluding AMG827):
	 	[*]	 	[*]	 	[*]	 	[*]
	 				 
	 Net Revenues

(AMG827 only):
	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 

 Taking the third quarter as a representative example, the Inventorship Margin would be calculated as
follows: 
 In Q3 2017, quarterly Net Revenues (excluding AMG827) are [*] and quarterly Net Revenues (AMG827 only) are [*]. The
[*]% rate is applied to the [*] in Q3 2017 Net Revenues (excluding AMG827) and the [*]% rate is applied to the [*] in Q3 2017 Net Revenues (AMG827 only). The Inventorship Margin for the quarter is therefore [*] ([*] x [*] + [*] x [*] = [*]).

 II.        Collaboration Profit (Loss). To determine the Collaboration
Profit (Loss) in accordance with Section 7.2.8 (Calculation of Profit (or Loss)), each Party’s share of Net Revenues must be determined pursuant to Section 7.2.8.2 (Profits) and Total Costs pursuant to Section 7.2.8.1 (Costs) for
the quarter. 
 Assume for purposes of this example that Net Revenues for Q3 2017 are [*] and the
Inventorship Margin is [*] (consistent with the example above). Further assume the following for Q3 2017: 
  

							
	 	  	Total	  	Amgen	  	    Partner    
	 Net Revenues
	  	[*]	  	[*]	  	[*]
	 Inventorship Margin
	  	[*]	  	[*]	  	[*]
	 Share of Net Revenues
	  	[*]	  	[*]	  	[*]
	 Collaboration Costs
	  	[*]	  	[*]	  	[*]
	 True-Up Payment
	  		  	[*]	  	[*]
	 	  	 	  	 	  	 

 In such a case, each Party’s share of Net Revenues for Q3 2017 would be
[*] ([*]-[*] = [*] / [*] = [*]). 
 Each Party’s share of the Total Costs for Q3 2017 would be [*],
representing Total Costs of [*] multiplied by the Quarterly Cap of 50% for Q3 2017. In this example, each Party incurred [*] of costs in such quarter, thus no netting would be required. 

In this example, Partner would be entitled to a true-up payment from Amgen of [*], representing Partner’s share of
the Net Revenues less the amount of Net Revenues collected by Partner in Q3 2017 ([*]-[*] = [*]). 
 If, however,
the Total Costs that had been incurred by each Party in the quarter differed, then each Party’s share of the Collaboration Profit (Loss) for Q3 2017 for the quarter would need to be adjusted. For this example, assume the following: 

 

							
	 	  	Total	  	Amgen	  	Partner
	 Net Revenues
	  	[*]	  	[*]	  	[*]
	 Inventorship Margin
	  	[*]	  	[*]	  	[*]
	 Share of Net Revenues
	  	[*]	  	[*]	  	[*]
	 Collaboration Costs
	  	[*]	  	[*]	  	[*]
	 True-Up Payment
	  		  	[*]	  	[*]
	 	  	 	  	 	  	 

 In such a case, each Party’s share of Net Revenues for Q3 2017 would still be [*],
([*]-[*] = [*] / [*] = [*]). 
 Additionally, each Party’s share of the Total Costs for Q3 2017 would still
be [*], representing Total Costs of [*] multiplied by the Quarterly Cap of 50% for Q3 2017. However, Partner would owe [*] to Amgen as reimbursement for its share of Total Costs (([*] x [*]) - [*] = [*]). 

In this example, Partner would be entitled to a true-up payment of [*], representing Partner’s share of the Net
Revenues, less (i) the amount of Net Revenues collected by Partner in Q3 2017 and (ii) the amount owed to Amgen to cover Partner’s share of Total Costs ([*]-[*] - [*] = [*]). 

 Schedule 
 Quality Agreement 

 Finished Drug Product and Placebo 

QUALITY AGREEMENT 
 Between 
 AstraZeneca Collaboration Ventures, LLC 

Hereafter referred to as “PARTNER” 
 and 
 Amgen Inc. 

Hereafter referred to as “AMGEN” 
 This Quality Agreement is intended by the Parties to set forth a plan for the quality assurance groups of AMGEN and PARTNER to work in relation to the manufacture, labeling, packaging, testing, release,
shipment and storage of the clinical drug product supply of AMG 139, AMG 157, AMG 181, AMG 557, AMG 827, and the placebo form of the clinical drug products for PARTNER’s use in the Collaboration Territory. The specific details for each molecule
will be outlined in addendums to the Quality Agreement. By signing below, the respective quality assurance representatives acknowledge and agree to the provisions of this Quality Agreement. 

 

							
	Agreed and accepted for:	  	Agreed and accepted for:
		
	Partner	  	Amgen Inc.
				
	By:	  	                             
                         	  	By:	  	                             
                         
		
	Printed	  	Printed
				
	Name:	  	  Michael Kinley	  	Name:	  	  Astrid McLean
				
	Title:	  	  Sr. Director, Quality Assurance	  	Title:	  	  Director, Quality Assurance
				
	Date:	  	                             
                         	  	Date:	  	                             
                         

 Effective Date:     March 30, 2012 

  
 1 

 Table of contents 

 

							
	 1.
	    	BACKGROUND INFORMATION	  	 	3	  
			
	 2.
	    	SCOPE	  	 	3	  
			
	 3.
	    	DEFINITIONS	  	 	4	  
			
	 4.
	    	RESPONSIBILITIES	  	 	6	  
			
	 5.
	    	COMMUNICATION	  	 	6	  
			
	 6.
	    	BATCH DISPOSITION (PRODUCT RELEASE)	  	 	7	  
			
	 7.
	    	LABEL APPROVAL	  	 	8	  
			
	 8.
	    	QUALITY CONTROL	  	 	8	  
			
	 9.
	    	REFERENCE SAMPLES	  	 	9	  
			
	 10.
	    	RETENTION SAMPLES	  	 	9	  
			
	 11.
	    	RECEIVING, SHIPPING, STORAGE AND DESTRUCTION	  	 	9	  
			
	 12.
	    	CHANGE CONTROL	  	 	10	  
			
	 13.
	    	INVESTIGATIONS OF NONCONFORMANCES, DISCREPANCIES (POST DISTRIBUTION NC’S)	  	 	11	  
			
	 14.
	    	AUDITS AND INSPECTIONS	  	 	11	  
			
	 15.
	    	DISPUTE RESOLUTION	  	 	13	  
			
	 16.
	    	CUSTOMER COMPLAINTS	  	 	13	  
			
	 17.
	    	STOCK RECOVERY	  	 	13	  
			
	 18.
	    	RESPONSIBLE PERSONS: CONTACT INFORMATION	  	 	14	  
		
	 EXHIBIT A
	  	 	15	  

  

  
 2 

	1.	BACKGROUND INFORMATION 

  

	 	1.1	Amgen Inc. (hereinafter referred to as “AMGEN”) and Partner (hereinafter referred to as “PARTNER”) (hereinafter referred to individually as
“Party” or collectively as “Parties”) have entered into that certain Collaboration Agreement dated as of March 30, 2012 (the “Collaboration Agreement”), pursuant to which AMGEN supplies PARTNER with Drug Product
and Placebo. 

  

	2.	SCOPE 

  

	 	2.1	This Quality Agreement defines the quality obligations of the Parties and their respective affiliates or approved contractors, with respect to the manufacture,
labeling, packaging, testing, release, shipment and storage of Product in accordance with the Collaboration Agreement. 

  

	 	2.2	The provisions of this Quality Agreement supplement the provisions of the Collaboration Agreement. The terms of the Collaboration Agreement shall remain in full force
and effect. In the event of any conflict between the Collaboration Agreement and this Quality Agreement, the Collaboration Agreement shall govern over the conflict. 

 

	 	2.3	This Quality Agreement may be amended only by mutual written agreement of the Parties. 

 

	 	2.4	Exhibits to this Quality Agreement are intended to provide additional definition to the applicable topic and, as such, should be updated to reflect the current
information and business process, as applicable. Amendment of the Exhibits does not require re-approval of the Quality Agreement unless the Quality Agreement itself is affected. Exhibits and all amendments of Exhibits shall be approved by mutually
written agreement by the Parties. 

  

	 	2.5	All activities under this Quality Agreement shall be performed in compliance with standard industry practices, regulatory agency guidelines, AMGEN specifications, and
all applicable federal, state, and local laws and regulations, including, without limitations, cGMPs. 

  

	 	2.6	This Quality Agreement shall expire at the termination, cancellation, or expiration, as the case may be, of AMGEN’s obligation to supply Drug Product and Placebo
for PARTNER’s clinical use. 

  

	 	2.7	PARTNER’s use of Product shall be limited to use in clinical trials approved by the Joint Steering Committee (JSC) as defined in the Collaboration Agreement and
where PARTNER has been allocated responsibility to conduct such clinical trials. 

  
 3 

	3.	DEFINITIONS 

  

	 	3.1	All capitalized terms not otherwise defined in this Quality Agreement shall have the definition set forth in the Collaboration Agreement. 

 

	 	3.2	As used in this Quality Agreement, the following terms shall have the following meanings: 

 

			
	CoA	  	Certificate of Analysis prepared by AMGEN for the Product
representing the analytical results of the Product.
	CoC	  	Certificate of Compliance or Quality Assurance Disposition (QAD), prepared by AMGEN for
the Product representing that the Product was manufactured according to cGMP requirements.
	
Disposition
 Manager
	  	AMGEN Quality Assurance staff member qualified to perform the comprehensive quality
assessment and make the disposition decision.
	
Disposition
 Package
	  	Documentation set provided to PARTNER representing AMGEN batch disposition of the
Product.
	Drug Product	  	AMG 139, AMG 157, AMG 181, AMG 557, AMG 827 Drug Product in finished form as
manufactured by AMGEN under the terms of the Collaboration Agreement.
	Final Release	  	Release of Product by AMGEN or PARTNER in accordance with standard operating procedures
(“SOPs”).
	cGMP	  	All applicable laws and regulations relating to current Good Manufacturing Practices,
as promulgated by the United States Food and Drug Administration (FDA) and ‘Good Manufacturing Practices as defined in EC Volume IV of The Rules Governing Medical Products in the European Community’.
	 Manufacturer’s

Release
	  	Release of Product by AMGEN, according to its SOPs. Manufacturer’s Release
signifies that Product has been produced using approved processes, in compliance with applicable cGMP regulations, and meets the specifications established for the Product, as determined by review of all appropriate documentation.
	Material Change	  	A change which materially modifies the regulatory filing
for the Product or is determined by AMGEN to have significant potential to materially affect the Safety, Quality, Identity, Potency, or Purity of the Product.

  
 4 

			
	Nonconformance	  	Deviations incurred during the manufacture, labeling,
packaging, testing, storage or shipment of the Product, which AMGEN determined to have the potential to impact the Safety, Quality, Identity, Potency, or Purity of the Product, upon preliminary evaluation and required performing an investigation
according to AMGEN SOPs.
	OOS Result	  	An examination, measurement or test result that does not conform with pre-established
specification requirements established by the relevant Party.
	Placebo	  	A mock treatment or drug that has no effect on the illness, given in a clinical trial
to the control group to help differentiate the specific versus non-specific effects of an experimental treatment.
	Product	  	The Drug Product and finished Placebo as manufactured by
AMGEN for PARTNER under the terms of the Collaboration Agreement.
	Regulatory Agency	  	A public authority or government agency responsible for protecting and promoting public
health through regulation or rulemaking (codifying and enforcing rules and regulations and imposing supervision or oversight for the benefit of the public at large).
	Reference Sample  	  	Sample collected from the manufacture of Product for the purpose of being analyzed,
should the need arise, to support significant investigations.
	Retention Samples  	  	A fully packaged unit from a batch of finished Product stored for identification
purposes.
	AMGEN Quality Specifications	  	AMGEN approved set of analytical methods, requirements, and limits as used to judge the
identity, purity and potency of all source materials, raw materials, and finished filled, labeled and packaged Product which comprises the Product.
	Stock Recovery	  	The removal or correction of a non-marketed product used in a clinical trial for
reasons related to product Safety, Quality, Identity, Potency, or Purity, that has not been marketed or that has not left the direct control of PARTNER.

  
 5 

	4.	RESPONSIBILITIES 

  

	 	4.1	Without limiting any other provision of this Quality Agreement, the Parties agree that this Quality Agreement is intended to carry out the following guiding principles:

  

	 	4.1.1	The Parties’ quality obligations with respect to the manufacture, labeling, packaging, testing, release, shipment and storage of Product are as set forth in this
Quality Agreement and the Collaboration Agreement. 

  

	 	4.1.2	The Parties shall comply with all Applicable Laws in the conduct of activities under this Quality Agreement. 

 

	 	4.1.3	The Parties acknowledge that AMGEN and PARTNER shall each have the right to perform responsibilities hereunder through their Affiliates and contractors.

  

	 	4.1.4	The Parties shall collaborate to address any disagreements. 

  

	5.	COMMUNICATION 

  

	 	5.1	AMGEN and PARTNER agree to provide verbal communication to one another, in a timely manner, as necessary or appropriate for a given issue. Both Parties also agree to
follow-up and clarify promptly in writing those important verbal communications to ensure clarity of issues. All official communications and documentation between AMGEN and PARTNER will be conducted in English. 

 

	 	5.1.1	The forwarding by PARTNER of any written communication from any global Regulatory Agency concerning the Product outlined in this document shall be done within 3
business days in the original language in which it was received by PARTNER with supplementary comments in English. An English translated version will also be forwarded. 

 

	 	5.1.2	The forwarding of any oral communication from any global Regulatory Agency concerning the Product outlined in this document shall be done within 3 business days in the
original language in which the notes concerning the correspondence were taken by PARTNER with supplementary comments in English. An English translated version will also be forwarded. 

 

	 	5.2	Routine verbal and written communications required herein shall be delivered to the individuals indicated in EXHIBIT A or their delegates. 

  
 6 

	6.	BATCH DISPOSITION (PRODUCT RELEASE) 

  

	 	6.1	AMGEN Quality Responsibility 

  

	 	6.1.1	AMGEN shall be responsible for the Manufacturer’s Release of the Product to PARTNER. 

 

	 	6.1.2	AMGEN shall provide to PARTNER the Disposition Package for each batch of Product supplied to PARTNER, upon shipment. The documents to be included in the Disposition
Package will be outlined in amendments which are specific to the Product. 

  

	 	6.1.3	The Disposition Package for the batch will include a list of Nonconformance(s) incurred during the manufacture, labeling, packaging, testing, or storage of the Product.
The list of Nonconformance(s) will include a summary of only lot-specific Nonconformances determined by AMGEN to have significant potential to adversely impact the Safety, Quality, Identity, Potency, or Purity of the Product, according to AMGEN
procedures or regulatory filing. Such list will be sent to PARTNER upon shipment of the Product by AMGEN to PARTNER. 

  

	 	6.1.4	AMGEN shall use commercially reasonable efforts to mitigate the risk of Transmissible Spongiform Encephalopathy (TSE) for raw materials and components used during
perform of Services per current requirements of Regulatory Agencies and current compendial requirements. 

  

	 	6.2	PARTNER Quality Responsibility 

  

	 	6.2.1	PARTNER shall be responsible for the Final Release of the Product for clinical distribution after reviewing the Disposition Package provided by AMGEN and any shipping
records and, if applicable, results of acceptance testing as conducted by a PARTNER qualified laboratory. 

  

	 	6.2.2	In the event PARTNER provides AMGEN with notice of Nonconformance of the Product within 60 days from the date of delivery of Product, AMGEN and PARTNER agree to
collaborate to investigate the Nonconformance prior to the disposition of the lot by PARTNER according to each Party’s respective failure investigation policies and procedures in accordance with the Quality Agreement. 

  
 7 

	 	6.2.3	In the event PARTNER is responsible for a specific European clinical trial, a PARTNER QP or one authorized by PARTNER, will be responsible for certification of Product
according to the requirements set out in the European cGMPs. 

  

	7.	LABEL APPROVAL 

  

	 	7.1	Physical Label Creation and Approval 

  

	 	7.1.1	Physical labels for Product will be generated and approved according to established procedures of AMGEN, for any such activities performed by such Party.

  

	 	7.1.2	Label Application 

  

	 	7.1.2.1	AMGEN is responsible for labeling and bulk packaging of the clinical supplies. 

 

	 	7.1.2.2	AMGEN shall apply physical labels to Product prior to supply to PARTNER. 

  

	8.	QUALITY CONTROL 

  

	 	8.1	AMGEN Quality Control Laboratory Testing Responsibility 

  

	 	8.1.1	AMGEN will conduct testing of Product according to AMGEN Quality Specifications and its methods, policies and procedures. 

 

	 	8.2	PARTNER Importation and Testing Responsibility 

  

	 	8.2.1	PARTNER shall be responsible for preparing all documents required for import clearance and entry of shipment with reasonable cooperation from AMGEN. Product batches
will be evaluated by PARTNER upon receipt for conformance to applicable import and transport requirements, such as temperature monitoring, damage and documentation requirements. 

 

	 	8.2.2	PARTNER is responsible for sampling upon receipt and conducting testing, as required. Such testing will be conducted by PARTNER (or if AMGEN expressly consent in
writing, by appropriately qualified laboratories) by appropriately qualified personnel according to testing procedures mutually agreed by the Parties. 

  

	 	8.2.3	 If AMGEN expressly consents to PARTNER using a contract laboratory for import testing, then PARTNER is responsible for

  
 8 

	 	 
shipping Product to its contract laboratory to perform import testing, if necessary. 

  

	 	8.2.4	In the case of OOS, an investigation will be performed per Section 13 (INVESTIGATION OF NONCONFORMANCES, DISCREPANCIES) of this Quality Agreement and PARTNER
should notify and obtain consent from AMGEN prior to conducting testing using any other analytical method during the investigation. 

  

	 	8.3	Stability Tesing 

  

	 	8.3.1	AMGEN will conduct routine stability testing of the Product according to AMGEN’s clinical stability program requirements. 

 

	 	8.3.2	AMGEN will communicate the expiration of each lot in the Disposition Package. 

 

	 	8.3.3	AMGEN shall notify PARTNER within two (2) business days of any confirmed stability failure of the Product and provide periodic updates on the OOS investigation.

  

	 	8.3.4	PARTNER will not conduct any stability testing on the Product unless authorized to do so by AMGEN. 

 

	 	8.3.5	AMGEN will provide PARTNER the current Stability Summary Report, including trending, upon request. 

 

	9.	REFERENCE SAMPLES 

  

	 	9.1	AMGEN shall retain Reference Samples for each manufactured lot of Product released to PARTNER for a minimum of five (5) years after the expiration period. This
period may be shortened if the period of stability of the material, as indicated in its specification, is shorter. 

  

	10.	RETENTION SAMPLES 

  

	 	10.1	PARTNER shall retain Retention Samples for each packaged lot of Product released for clinical distribution per established PARTNER procedure. 

 

	11.	RECEIVING, SHIPPING, STORAGE and DESTRUCTION 

  
 9 

	 	11.1	Unless otherwise agreed by the Parties, AMGEN shall ship Product EXW (Incoterms 2010) AMGEN’s facility. 

 

	 	11.2	PARTNER is responsible for reviewing temperature recording data upon receipt of Product shipment. 

 

	 	11.3	PARTNER is responsible for adequate storage of the Product upon receipt according to the storage requirements specified in the product specification.

  

	 	11.4	Shipping excursions will be investigated per Section 13 (INVESTIGATIONS OF NONCONFORMANCES, DISCREPANCIES) of this Quality Agreement. 

 

	 	11.5	PARTNER is responsible for reviewing temperature recording data of the Product according to the storage requirements if a temperature excursion is identified at a
clinical investigation site. 

  

	 	11.5.1	PARTNER notifies AMGEN of any shipping Nonconformances, such as temperature excursions, upon receiving shipping records. 

 

	 	11.5.2	AMGEN shall provide PARTNER adequate training and relevant stability data to support temperature excursions obtained at clinical investigation sites, provided that,
AMGEN shall not have any obligation to conduct new tests to support assessment of temperature excursions. If a temperature excursion exceeds any of the limits supported by the stability data, AMGEN shall provide reasonable support to properly assess
the product impact, if requested by PARTNER. 

  

	 	11.6	PARTNER shall be responsible for the destruction of any unused and partially used Product in accordance with Applicable Laws and regulations. 

 

	12.	CHANGE CONTROL 

  

	 	12.1	AMGEN shall notify PARTNER of AMGEN’s intention to implement such Material Change and the details of such Material Change for the material changes of manufacturing
of the Product, specifically impacting the following documents, if applicable: (1) Analytical Methods, (2) Master Batch/Labeling/Packaging Records, (3) Primary Packaging Components Specifications, (4) Product Specifications, and
(5) Raw Material/Component Specifications. 

  

	 	12.2	 Within fourteen (14) calendar days after the receipt of such notification, to the extent such Material Change impacts a Regulatory Filing for
which PARTNER is the Designated Regulatory Party, PARTNER shall provide to AMGEN a written 

  
 10 

	 	 
assessment of whether the Material Change constitutes a change which is reportable to Governmental Authorities. 

 

	 	12.3	If a Material Change requires the approval of a Governmental Authority in the Collaboration Territory, then, where PARTNER is the Designated Regulatory Party, PARTNER
shall use reasonable efforts to file for such approval within sixty (60) days of receipt of the necessary documentation from AMGEN and obtain necessary regulatory approvals. 

 

	 	12.4	PARTNER shall provide updates to AMGEN of any regulatory submissions relating to said changes. 

 

	 	12.5	PARTNER shall inform AMGEN of any required regulatory change and reporting category in writing within two (2) business days after PARTNER first becomes aware of
such information. PARTNER must inform AMGEN of the request in writing, at a minimum the request should describe the proposed change and rationale. 

  

	 	13.	INVESTIGATIONS OF NONCONFORMANCES, DISCREPANCIES (POST DISTRIBUTION NC’S) 

 

	 	13.1	If a Nonconformance is identified after a Product batch has been shipped to PARTNER, AMGEN shall inform PARTNER within two (2) business days of such
Nonconformance. 

  

	 	13.2	AMGEN will provide support, as necessary and reasonable, to enable PARTNER to comply with applicable regulatory reporting requirements that may result from the
occurrence of a post-distribution Nonconformance. 

  

	 	13.3	Each Party shall inform the other Party as soon as reasonably possible of issues which may adversely impact Product quality, safety, efficacy or adverse events relating
to the batch of Product received by PARTNER. 

  

	 	14.	AUDITS AND INSPECTIONS 

  

	 	14.1	PARTNER Audits 

  

	 	14.1.1	 All audits of AMGEN are limited to the facilities where the Products are manufactured, Quality Systems and documentation directly related to the

  
 11 

	 	 
Products, and Batch Records related to lots provided to PARTNER, The scope, agenda, and timeline must be approved by AMGEN prior to each audit. 

 

	 	14.1.2	All audits of AMGEN facilities will be conducted during regular business hours in the presence of AMGEN representatives. Audits shall be conducted by not more than two
(2) PARTNER representatives at each AMGEN facility, and, unless otherwise agreed upon by AMGEN, for not more than two (2) business days at each site. PARTNER shall provide AMGEN written notification of such audit no less than one hundred
twenty days (120) days in advance. The written notification must clearly state the scope of the audit and regulatory standards to be used to conduct the audit. PARTNER may conduct an audit once in a twelve (12) month period, upon
AMGEN’s approval of the audit request. 

  

	 	14.1.3	In addition to the annual audit described in Section 14.1.2 above, PARTNER is permitted to request an unplanned “For Cause” audit during the case of a
quality or regulatory event. AMGEN will consider any such request in good faith, but will have sole discretion whether or not to grant such request. 

  

	 	14.1.3.1	Such “For Cause” audits require prior written notice by PARTNER to AMGEN and shall be conducted during AMGEN’s normal business hours. Each party must
approve the audit scope, agenda and timeline prior to conducting the audit. For Cause audits shall be conducted by not more than two (2) PARTNER representatives at each AMGEN facility, and, unless otherwise agreed upon by AMGEN, for not more
than two (2) business days. 

  

	 	14.2	Audit Findings 

  

	 	14.2.1	PARTNER shall provide AMGEN a copy of the audit report within thirty (30) calendar days of completion of an audit. After delivery of the audit report, AMGEN shall
provide PARTNER with a written response to such report within thirty (30) calendar days from AMGEN’s receipt of the report from PARTNER. All information contained in the audit report shall be deemed the confidential information of AMGEN
under the Collaboration Agreement. 

  

	 	14.3	Regulatory Agency Inspections 

  

	 	14.3.1	PARTNER shall notify AMGEN immediately upon notification by any Regulatory Agency or other Government Authority of any intended inspection of AMGEN’s facilities or
records relating to the manufacturing, testing, packaging, labeling, and storage of the Product. 

  
 12 

	 	14.3.2	PARTNER shall have the right to have a maximum of one (1) representative present during a regulatory inspection of AMGEN’s facilities that perform
manufacturing or testing of Product. Presence of PARTNER during an inspection at an AMGEN facility will be according to the direction of AMGEN. PARTNER representative shall not have direct participation during inspection discussions with Regulatory
Agency inspector(s). 

  

	 	14.3.3	AMGEN shall provide PARTNER with a copy of the final response immediately after submission to the Regulatory Agency. 

 

	 	14.3.4	PARTNER is responsible for the arrangement of interpreters and translation of documents which may be required by the Regulatory Agency during inspection of AMGEN
facilities. AMGEN shall have the right to arrange interpreter and document translation services upon agreement with PARTNER or if PARTNER fails to do so. 

  

	 	15.	DISPUTE RESOLUTION 

  

	 	15.1	Disputes relating to non-compliance or nonconformance of Product with the product specifications shall be governed by the terms set forth in the Collaboration
Agreement. The provisions of Section 15.3 (choice of law; jurisdiction) of the Collaboration Agreement are deemed incorporated into this Quality Agreement. 

 

	 	16.	CUSTOMER COMPLAINTS 

  

	 	16.1	Any information related to customer complaints (i.e., communication that alleges deficiencies relating to the identity, quality, durability, reliability, safety,
effectiveness, or performance of a drug, condition of labeling, or packaging, after it is released by PARTNER for clinical studies) shall be forwarded to AMGEN within one (1) business day after PARTNER first becomes aware of such information.

  

	 	16.2	AMGEN shall investigate according to AMGEN’s applicable policy and procedures customer complaints submitted by PARTNER. Complaints which require an AMGEN
investigation will be sent to this e-mail address: XXXXXXXXX@amgen.com 

  

	 	16.3	AMGEN shall provide PARTNER with an Interim Report within 30 days and an investigation closure Final Report within forty-five (45) days of receipt of the customer
complaint. 

  

	17.	STOCK RECOVERY 

  
 13 

	 	17.1	If any problems are discovered and identified as recall/stock recovery issues related to the Product, the discovering Party shall notify the other immediately.

  

	 	17.2	PARTNER and AMGEN shall each notify the other Party within three (3) business days if it becomes aware that any Product is alleged or proven to be the subject of a
recall or stock recovery in the Collaboration Territory. 

  

	 	17.3	The Parties shall meet to discuss the circumstances that merit the Product recall or stock recovery and to determine the appropriate course of action. Such course of
action shall be consistent with the internal SOP of the Party having the right to control such recall pursuant to this section. 

  

	 	17.4	If either Party proposes to initiate a Stock Recovery or other corrective action with respect to the Product in the Collaboration Territory, the Parties will promptly
discuss such proposed action. Any decisions by the Parties shall be governed by the terms of the Collaboration Agreement. The Parties shall cooperate, as reasonably necessary, in the implementation of such actions. 

 

	 	17.5	The Parties shall cooperate and promptly perform investigations into the root causes leading up to the Product Stock Recovery, when appropriate. Investigation reports
regarding the defect or cause for such regulatory reporting shall be provided to the corresponding Party within an appropriate timeframe dependent on regulatory reporting requirements. 

 

	 	17.6	The Parties shall each maintain complete and accurate records of any Stock Recovery it has the right to control pursuant to this section of the Quality Agreement for
such periods as may be required by legal requirements, but in any event for no less than three (3) years from the date of Stock Recovery. 

  

	 	17.7	Each Party maintains the responsibility for Product distributed within the Collaboration Territory for its own clinical studies. 

 
  

	18.	RESPONSIBLE PERSONS: CONTACT INFORMATION 

  

	 	18.1	The individuals listed in EXHIBIT A shall be the key points of contact between AMGEN and PARTNER relating to the rights and obligations of the Parties in this Quality
Agreement. The responsible individuals, or their respective delegates, must be notified in official communications as required by this Quality Agreement. 

  
 14 

 EXHIBIT A 
 Responsible Persons and Contact Information 
  
  

							
	  
 AMGEN
  

	  

Name
  
	 	Email Address	 	Contact Number	 	Responsibility
	  

XXXXXXXXX
  
	 	 XXXXXXXXX

 
	 	 XXXXXXXXX

 
	 	 Manager,

International Quality

	  

XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	 Director,

International Quality

  
  

							
	  
 PARTNER
  

	  

Name
  
	 	 Email
Address
  
	 	 Contact
Number
  
	 	
Responsibility

 

	  

XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	 Director of QA and EU QP

 

	  

XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	  
 XXXXXXXXX
  
	 	 Senior Director,

 
 Quality Assurance

  
 Exhibit A Version
Date:    March 30, 2012 
  

									
	 Agreed and accepted for:
  

Partner
	 	 Agreed and accepted for:
  

Amgen Inc.
	 	
					
	By:	 	  
	 	By:	 	  
	 	
					
	 Printed
  
 Name:
	 	  Michael Kinley	 	 Printed
  
 Name:
	 	  Astrid McLean	 	
					
	Title:	 	  Sr. Director, Quality Assurance	 	Title:	 	  Director, Quality Assurance	 	
					
	Date:	 	  
	 	Date:	 	  
	 	

  
 15 

 Schedule 
 Stage 1 Clinical Trial 
  

			
	 Product

 
	  	 Stage 1 Clinical Trial
  

	
AMG139
  
	  	 [*]

 

	
AMG157
  
	  	 [*]

 

	
AMG181
  
	  	 [*]

 

	
AMG557
  
	  	 [*]

 

	
AMG827
  
	  	 [*]Loan and Security Agreement

 Exhibit 10.2 
 EXECUTION VERSION 
 LOAN AND SECURITY AGREEMENT 

THIS LOAN AND SECURITY AGREEMENT (this “Agreement”), dated as of January 25, 2012 (the “Effective
Date”) by and among MIDCAP FINANCIAL SBIC, LP, a Delaware limited partnership (“MidCap”), as administrative agent (“Agent”), the Lenders listed on Schedule 1 hereto and otherwise party hereto
from time to time (each a “Lender”, and collectively the “Lenders”), TRIA BEAUTY, INC., a Delaware corporation (“Tria”) and each other Person that becomes a co-borrower pursuant to
Section 6.11 hereof (collectively with Tria, “Borrower”), provides the terms on which Lenders agree to lend to Borrower and Borrower shall repay Lenders. The parties agree as follows: 

 

	 	1	ACCOUNTING AND OTHER TERMS 

 Accounting terms not defined in this Agreement shall be construed in accordance with GAAP. Calculations and determinations must be made in accordance with GAAP. Capitalized terms not otherwise defined in
this Agreement shall have the meanings set forth in Section 14. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the extent such terms are defined therein. 

 

	 	2	LOAN AND TERMS OF PAYMENT 

 2.1 Promise to Pay. Borrower hereby unconditionally promises to pay to each Lender in accordance with its respective Pro Rata Share, the outstanding principal amount of all Credit Extensions
made by the Lenders, and accrued and unpaid interest thereon, and any other amounts due hereunder as and when due in accordance with this Agreement. 
 2.1.1 Term Loans. 
 (a) Availability. Subject to the terms
and conditions of this Agreement, the Lenders agree, severally and not jointly, to make term loans to Borrower on the Effective Date in an aggregate amount equal to Twenty Million Dollars ($20,000,000) according to each Lender’s Term Loan
Commitment as set forth on Schedule 1 hereto (such term loans are hereinafter referred to collectively as the “Term A Loan”). Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not jointly,
during the Draw Period, to make term loans to Borrower, upon the request of Borrower, in an aggregate amount up to Seven Million Dollars ($7,000,000) according to each Lender’s Term Loan Commitment as set forth on Schedule 1 hereto (such term
loans are hereinafter referred to collectively as the “Term B Loan”; the Term A Loan or the Term B Loan is hereinafter referred to singly as a “Term Loan” and collectively as the “Term Loans”). After
repayment, no Term Loan may be re-borrowed. 
 (b) Repayment. 

(i) The Term A Loan. Borrower shall make monthly payments to each Lender in an amount equal to all interest accrued and owing to
each Lender in respect of such Lender’s Term A Loan, commencing on the first (1st) Payment Date following the Funding Date of the Term A Loan, and continuing on the Payment Date of each successive month thereafter through and including the
Maturity Date. Commencing on the Amortization Date and continuing on the Payment Date of each successive month thereafter through and including the Maturity Date, Borrower shall repay the Term A Loan in thirty (30) equal installments of
principal (it being acknowledged that the final installment amount may be immaterially different than the other installment payments) to each Lender in respect of such Lender’s Pro Rata Share of the Term A Loan. Borrower’s final payment on
the Term A Loan, due on the Maturity Date, shall include all outstanding principal and accrued and unpaid interest under the Term A Loan and all other outstanding Obligations. Once repaid, the Term A Loan may not be reborrowed. The Term A Loan may
only be prepaid in accordance with Sections 2.1.1(c) and 2.1.1(d). 

  
 1 

 (ii) The Term B Loan. Borrower shall make monthly payments to each Lender in an
amount equal to all interest accrued and owing to each Lender in respect of such Lender’s Term B Loan, commencing on the first (1st) Payment Date following the Funding Date of the Term B Loan, and continuing on the Payment Date of each
successive month thereafter through and including the Maturity Date. Commencing on the Amortization Date and continuing on the Payment Date of each successive month thereafter through and including the Maturity Date, Borrower shall repay the Term B
Loan in thirty (30) equal installments of principal (it being acknowledged that the final installment amount may be immaterially different than the other installment payments) to each Lender in respect of such Lender’s Pro Rata Share of
the Term B Loan. Borrower’s final payment on the Term B Loan, due on the Maturity Date, shall include all outstanding principal and accrued and unpaid interest under the Term B Loan and all other outstanding Obligations. Once repaid, the Term B
Loan may not be reborrowed. The Term B Loan may only be prepaid in accordance with Sections 2.1.1(c) and 2.1.1(d). 
 (c)
Mandatory Prepayments. If the Term Loans are accelerated following the occurrence of an Event of Default, Borrower shall immediately pay to each Lender or Agent, as applicable, in accordance with its Pro Rata Share (other than with respect to
Lender Expenses, which shall be paid to each Lender or Agent, as applicable, entitled thereto), an amount equal to the sum of: (i) all outstanding principal of the Term Loans, all other Obligations and all accrued interest thereon through the
prepayment date, (ii) the Final Payment, (iii) the Prepayment Fee, plus (iv) all other sums that shall have become due and payable to such Lender or Agent, as applicable, including Lender Expenses and interest accrued at the Default
Rate with respect to any past due amounts, if any. Notwithstanding (but without duplication with) the foregoing, on the Maturity Date if the Final Payment had not previously been paid in full in connection with the prepayment of the Term Loans in
full, Borrower shall pay to each Lender, the Final Payment in respect of the Term Loans made to Borrower by such Lender. 
 (d)
Permitted Prepayment of Term Loans. Borrower shall have the option to prepay the Term Loans, in whole or in part, which prepayments shall be paid to each Lender or Agent, as applicable, in accordance with its Pro Rata Share (other than with
respect to Lender Expenses, which shall be paid to each Lender or Agent, as applicable, entitled thereto); provided Borrower (i) provides written notice to Agent and each Lender of its election to prepay the Term Loans at least ten
(10) Business Days prior to such prepayment, and (ii) (x) in the case of a prepayment of an entire Term Loan, pays to each Lender or Agent, as applicable, on the date of such prepayment, an amount equal to the sum of: (A) all
outstanding principal of such Term Loan and all other Obligations, and all accrued interest thereon through the prepayment date, plus (B) the Final Payment, plus (C) the Prepayment Fee, plus (D) all other sums
that shall have become due and payable to such Lender or Agent, as applicable, including Lender Expenses and interest at the Default Rate with respect to any past due amounts, if any, and, (y) in the case of a prepayment of a portion of the
Term Loans, pays to each Lender or Agent, as applicable, on the date of such prepayment, an amount equal to the sum of: (A) the amount of the outstanding principal of such Term Loan prepaid and all accrued interest thereon through the
prepayment date, plus (B) the Partial Final Payment, plus (C) the Prepayment Fee, plus (D) all other sums that shall have become due and payable to such Lender or Agent, as applicable, including Lender Expenses
and interest at the Default Rate with respect to any past due amounts, if any. Borrower shall not make, and no Lender shall accept, any voluntary partial prepayment of any Term Loan on any date unless, concurrently therewith, Borrower shall make
voluntary partial prepayments with respect to all of the respective Term Loans of each Lender. 
 2.2 Intentionally
Omitted. 
 2.3 Payment of Interest on the Credit Extensions. 

(a) Interest Rate. Subject to Section 2.3(b), the principal amount outstanding under each Term Loan and all other outstanding
Obligations shall accrue interest at a per annum rate equal to the Basic Rate, fixed on the Funding Date of each Term Loan and all other outstanding Obligations shall accrue interest at the highest of the interest rates for the Term Loans. All such
interest shall be payable monthly in accordance with Section 2.1(b). 
 (b) Default Rate. Immediately upon the
occurrence and during the continuance of an Event of Default, the outstanding principal amount of the respective Term Loans made by each Lender, and all other outstanding Obligations shall bear interest at a rate per annum which is five percentage
points (5.00%) above the rate that is otherwise applicable thereto (the “Default Rate”) unless Agent otherwise elects from time to time in its 

  
 2 

 
sole discretion to impose a smaller increase. Fees and expenses which are required to be paid by Borrower pursuant to the Loan Documents (including, without limitation, Lender Expenses) but are
not paid when due shall bear interest until paid at a rate equal to the highest rate applicable to the Obligations. Payment or acceptance of the increased interest rate provided in this Section 2.3(b) is not a permitted alternative to timely
payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Agent or the Lenders. 
 (c) Intentionally Omitted. 
 (d) Computation; 360-Day Year. In
computing interest, the date of the making of any Credit Extension shall be included and the date of payment shall be excluded; provided, however, that if any Credit Extension is repaid on the same day on which it is made, such day shall be
included in computing interest on such Credit Extension. Interest shall be computed on the basis of a 360-day year for the actual number of days elapsed. 
 (e) Debit of Accounts. Agent or any of the Lenders may debit any of Borrower’s Deposit Accounts, including the Designated Deposit Account, for principal and interest payments or, following any
cure period provided in Section 8.1, any other amounts Borrower owes Agent or the Lenders when due. These debits shall not constitute a set-off. 
 (f) Payment Date. Unless otherwise provided, interest and principal, if applicable, are payable monthly on the first calendar day of each month (each a “Payment Date”) 

2.4 Fees. Borrower shall pay each Lender and, if applicable, Agent: 

(a) Final Payment and Partial Final Payment. The Final Payment and the Partial Final Payment, as applicable, with respect to its
Term Loans, when due hereunder; 
 (b) Prepayment Fee. The Prepayment Fee with respect to its Term Loans, when due
hereunder; and 
 (c) Lender Expenses. All Lender Expenses (including reasonable external attorneys’ fees and
reasonable, out-of-pocket expenses for documentation and negotiation of this Agreement) incurred through and after the Effective Date, when due (and in the absence of any other due date specified herein, such Lender Expenses due after the Effective
Date shall be due within three (3) Business Days of demand therefor). 
 2.5 Payments; Application of Payments.

 (a) All payments (including prepayments) to be made by Borrower under any Loan Document shall be made in immediately
available funds in U.S. Dollars, without setoff or counterclaim, before 2:00 p.m. Eastern time on the date when due. Payments of principal and/or interest received after 2:00 p.m. Eastern time are considered received at the opening of business on
the next Business Day. When a payment is due on a day that is not a Business Day, the payment shall be due the next Business Day, and additional fees or interest, as applicable, shall continue to accrue until paid. 

(b) Agent and the Lenders shall apply the whole or any part of collected funds against the Term Loans, the order and method of such
application to be in the sole discretion of Agent or the Lenders, as applicable. Borrower shall have no right to specify the order to which Agent or the Lenders, as applicable, shall allocate or apply any payments required to be made by Borrower to
Agent or the Lenders, as applicable, or otherwise received by Agent or the Lenders, as applicable, under this Agreement when any such allocation or application is not specified elsewhere in this Agreement. 

2.6 Secured Promissory Notes. Each Term Loan shall be evidenced by a Secured Promissory Note in the form attached as
Exhibit D hereto (each a “Secured Promissory Note”), and shall be repayable as set forth herein. Borrower irrevocably authorizes each Lender to make or cause to be made, on or about the Funding Date of any Term Loan or at the
time of receipt of any payment of principal on such Lender’s Secured Promissory Note, an 

  
 3 

 
appropriate notation on such Lender’s Secured Promissory Note Record reflecting the making of such Term Loan or (as the case may be) the receipt of such payment. The outstanding amount of
each Term Loan set forth on such Lender’s Secured Promissory Note Record shall be prima facie evidence of the principal amount thereof owing and unpaid to such Lender, but the failure to record, or any error in so recording, any such amount on
such Lender’s Secured Promissory Note Record shall not limit or otherwise affect the obligations of Borrower hereunder or under any Secured Promissory Note to make payments of principal of or interest on any Secured Promissory Note when due.
Upon receipt of an affidavit of an officer of a Lender as to the loss, theft, destruction, or mutilation of its Secured Promissory Note, Borrower shall issue, in lieu thereof, a replacement Secured Promissory Note in the same principal amount
thereof and of like tenor. 
 2.7 Issuance of Warrants to Lenders. Borrower has duly authorized issuance of the
Warrants substantially in the form attached hereto as Exhibit E. 
 2.8 SBIC Acknowledgement. Borrower
acknowledges that MidCap has notified Borrower that MidCap is a Federal licensee under the Small Business Investment Act of 1958, as amended. 
  

	 	3	CONDITIONS OF LOANS 

3.1 Conditions Precedent to Initial Credit Extension. Each Lender’s obligation to make the initial Credit Extension is
subject to the condition precedent that Agent shall consent to or have received, in form and substance satisfactory to Agent, such documents, and completion of such other matters, as Agent may reasonably deem necessary or appropriate, including,
without limitation: 
 (a) duly executed original signatures to this Agreement, the Secured Promissory Notes in favor of each
Lender with a face amount equal to such Lender’s Term Loan Commitment, the Effective Date Warrants and the other Loan Documents required to be executed by Borrower, Agent or the Lenders on the Effective Date; 

(b) a payoff letter from SVB; 
 (c) evidence that (i) the Liens securing the Existing SVB Indebtedness will be terminated and (ii) the documents and/or filings evidencing the perfection of such Liens, including without
limitation any financing statements and/or Control Agreements, have or will, concurrently with the initial Credit Extension, be terminated; 
 (d) the Perfection Certificate of Borrower, together with the duly executed original signatures thereto; 
 (e) a legal opinion of Borrower’s counsel dated as of the Effective Date together with the duly executed original signatures thereto; 

(f) a copy of its Registration Rights Agreement/Investors’ Rights Agreement and any amendments thereto; 

(g) evidence satisfactory to Agent that the insurance policies required by Section 6.5 hereof are in full force and effect, together
with appropriate evidence showing lender loss payable and/or additional insured clauses and cancellation notice to Agent (or endorsements reflecting the same) in favor of Agent, for the ratable benefit of the Lenders; 

(h) completed SBA Forms 480, 652 and 1031 by Borrower; 
 (i) a funds flow and letter of direction executed by a Responsible Officer of Borrower and each Lender; and 
 (j) payment of the fees and Lender Expenses then due as specified in Section 2.4 hereof. 

  
 4 

 3.2 Conditions Precedent to all Credit Extensions. The obligation of each
Lender to make each Credit Extension, including the initial Credit Extension, is subject to the following conditions precedent: 

(a) except as otherwise provided in Section 3.5, timely receipt of an executed Payment/Advance Form; 

(b) the representations and warranties in this Agreement shall be true, correct, and complete in all material respects on the date of the
Payment/Advance Form and on the Funding Date of each Credit Extension; provided, however, that (A) such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in
the text thereof and (B) those representations and warranties expressly referring to a specific date shall be true, correct and complete in all material respects as of such date. Each Credit Extension is Borrower’s representation and
warranty on that date that the representations and warranties in this Agreement remain true, correct, and complete in all material respects; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, correct and complete in all material respects
as of such date; 
 (c) a certificate executed by the Secretary of Borrower, certifying that Agent and the Lenders may
conclusively rely on such certificate unless and until Borrower shall have delivered to Agent a further certificate canceling or amending such prior certificate, providing verification of the name(s) of the Person(s) authorized to execute the Loan
Documents to which Borrower is a party to on behalf of Borrower, together with a sample of the true signature(s) of such Person(s) and attaching (or for delivery of such certificate following the Effective Date, a statement of no change, if
applicable) (i) a true, correct, and complete copy Borrower’s board resolutions approving the transactions contemplated by this Agreement and the other Loan Documents to which Borrower is a party to certifying that such resolutions are in
full force and effect and authorizing and ratifying the execution, delivery, and performance by Borrower of the Loan Documents to which it is a party and (ii) Borrower’s Operating Documents duly executed. 

(d) a certificate of status/good standing of Borrower certified by the Secretary of State for the State of Delaware and, for the
Effective Date only, a certificate of foreign qualification from each jurisdiction where Borrower’s failure to be so qualified could reasonably be expected to have a Material Adverse Effect (as defined below), in each case as of a date no
earlier than thirty (30) days prior to the Effective Date or the Funding Date of the Term B Loan, as the case may be; 

(e) a certificate executed by a Responsible Officer of Borrower, in form and substance satisfactory to Agent, which shall certify as to
certain conditions to the funding of such Term Loan; 
 (f) with respect to each Term Loan, Borrower shall have delivered
Warrants to Agent for each applicable Lender in the form attached hereto as Exhibit E; 
 (g) no Default or Event of
Default shall have occurred and be continuing or result from the Credit Extension; 
 (h) current UCC lien, judgment, bankruptcy
and tax lien search results demonstrating that there are no other Liens on the Collateral, other than Permitted Liens (as defined below); 
 (i) Agent shall have received such other documents, agreements, instruments or information as Agent shall reasonably request; and 
 (j) in Agent’s sole discretion, there has not been a Material Adverse Change. 

3.3 Post-Closing Conditions. 
 (a) Within five (5) days after the Effective Date, Agent shall have received evidence satisfactory in its reasonable discretion that (i) all amounts on deposit in the Deposit Accounts of
Borrower, account 

  
 5 

 
numbers 1893962983 and 1893962744, maintained with Comerica Bank shall be transferred to one or more Deposit Accounts of Borrower maintained with SVB and (ii) such Deposit Accounts
maintained with Comerica Bank shall be closed; 
 (b) Within ten (10) days after the Effective Date, Agent shall have
received an original amended, restated and consolidated promissory note amending, restating and consolidating any and all loans made by Borrower to a Subsidiary, along with an endorsement in blank in form and substance satisfactory to Agent for such
amended, restated and consolidated promissory note; 
 (c) Within ten (10) days after the Effective Date, Agent shall have
received original promissory notes or other written instruments, as applicable, evidencing any and all loans made by Borrower to an employee of Borrower, along with an endorsement in blank in form and substance satisfactory to Agent for each such
original promissory or other written instrument; 
 (d) Within thirty (30) days after the Effective Date, Agent shall have
received duly executed original signatures to the Control Agreement with respect to the Collateral Accounts maintained with SVB; 
 (e) Within thirty (30) days after the Effective Date, Agent shall have received evidence satisfactory in its reasonable discretion that the chain of title evidencing the assignment and ownership of
the following Patents and Patent applications of Borrower has been corrected with the United States Patent and Trademark Office: 7,452,356, 7,981,111, US20040176823, US20040176754, US20060009749, US20070032847, US20080310836 and US20090097513;

 (f) Within sixty (60) days after the Effective Date, Agent shall have received duly executed original signatures to the
Access Agreements in respect of Borrower’s facilities for which Access Agreements are required hereunder; 
 (g) Within
ninety (90) days after the Effective Date, Agent shall have received duly executed original signatures to the Japanese Share Pledge Documents, the U.K. Share Pledge Documents and the Korean Share Pledge Documents; and 

(h) Within ninety (90) days after the Effective Date, through dissolution or otherwise, Borrower shall cause Once Again Me to be
dissolved or merged into the Borrower; provided, that (i) upon such dissolution or merger, all assets of Once Again Me shall have been transferred to the Borrower (including, without limitation, any amounts on deposit in the Once Again Me
Deposit Account) and the Once Again Me Deposit Account shall be closed and (ii) until such time as Once Again Me is dissolved or merged into Borrower, (A) neither Borrower nor any Subsidiary of Borrower shall be permitted to make any
Investments or Transfers into Once Again Me, (B) Once Again Me shall not, and Borrower shall not permit Once Again Me to incur any Indebtedness or other liabilities and (C) Once Again Me shall not, and Borrower shall not permit Once Again
Me to, conduct any business other than the ownership and maintenance of the Intellectual Property that it owned prior to being acquired by Borrower. 
 3.4 Covenant to Deliver. Except as otherwise provided in Section 6.13, Borrower agrees to deliver to Agent each item required to be delivered to Agent under this Agreement as a
condition precedent to any Credit Extension. Borrower expressly agrees that a Credit Extension made prior to the receipt by Agent of any such item shall not constitute a waiver by Agent or the Lenders of Borrower’s obligation to deliver such
item, and the making of any Credit Extension in the absence of a required item shall be in Agent’s sole discretion. 

3.5 Procedures for Borrowing. Subject to the prior satisfaction of all other applicable conditions to the making of a Term
Loan set forth in this Agreement, to obtain a Term Loan, Borrower must notify Agent (which notice shall be irrevocable) by electronic mail or facsimile no later than 2:00 p.m. Eastern time fifteen (15) Business Day before the proposed Funding
Date. The notice shall be a Payment/Advance Form, must be signed by a Responsible Officer or designee. Upon receipt of such Payment/Advance Form, Agent shall promptly provide a copy of the same to each Lender. Together with such notice, Borrower
shall deliver to Agent an executed Warrant for each applicable Lender, the form of which is attached hereto as Exhibit E. If Borrower satisfies the conditions of funding the Term Loan, each Lender shall disburse such Term Loan according to
such Lender’s Term Loan Commitment by transfer to the Designated Deposit Account. 

  
 6 

	 	4	CREATION OF SECURITY INTEREST 

 4.1 Grant of Security Interest. Borrower hereby grants Agent, for the ratable benefit of the Lenders, to secure the payment and performance in full of all of the Obligations, a continuing
security interest in, and pledges to Agent, for the ratable benefit of the Lenders, the Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof; provided, that, to the extent
that Borrower, as a lessee or sublessee under a real property lease, is prohibited by the terms of such lease from granting a security interest in such lease or under which such an assignment or Lien would cause a default to occur under such lease,
such leasehold interest shall not be deemed Collateral hereunder; provided, further, that (i) upon termination of such prohibition, such interest and any proceeds and products thereof shall immediately become Collateral without
any action by Borrower, Agent or any Lender or (ii) to the extent that such prohibition would be rendered ineffective pursuant to Section 9-407(a) of Article 9 of the Code, such interest and any proceeds and products thereof shall
constitute Collateral. 
 4.2 Priority of Security Interest. Borrower represents, warrants, and covenants that the
security interest granted herein is and shall at all times continue to be a first priority perfected security interest in the Collateral, subject only to Permitted Liens that have priority to Agent’s Liens solely by operation of applicable law
and subject, for the following Collateral, to the occurrence of the following (i) in the case of all Collateral in which a security interest may be perfected by filing a financing statement under the Code, the completion of the filings with the
appropriate filing office, (ii) with respect to any deposit account, commodities account or securities account held at a bank other than Agent, the execution of account control agreements by and among Agent, the owner of the account and the
financial institution where such account is maintained, (iii) in the case of letter of credit rights, the execution of a contractual obligation granting control (as “control” is contemplated as a manner of perfection in the applicable
sections of the Code) and (iv) in the case of investment property, instruments and chattel paper, the completion of all steps necessary to grant control (as “control” is contemplated as a manner of perfection in the applicable
sections of the Code) to Bank over such investment property, instruments and chattel paper. If Borrower shall acquire a commercial tort claim, Borrower shall promptly notify Agent in a writing signed by Borrower of the general details thereof and
grant to Agent, for the ratable benefit of the Lenders, in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance reasonably satisfactory to Agent.
Nothing in this Section 4.2 shall have any effect on the obligations of Borrower under Section 6.12. 
 4.3
Authorization to File Financing Statements. Borrower hereby authorizes Agent to file financing statements, without notice to Borrower, with all appropriate jurisdictions to perfect or protect Agent’s and the Lenders’ interest or
rights hereunder, including a notice that any disposition of the Collateral, except to the extent permitted by the terms of this Agreement, by either Borrower or any other Person, shall be deemed to violate the rights of Agent and the Lenders under
the Code. 
  

	 	5	REPRESENTATIONS AND WARRANTIES 

 Borrower represents and warrants as follows: 
 5.1 Due Organization,
Authorization; Power and Authority. Borrower and each of its Material Subsidiaries are duly existing and in good standing as Registered Organizations in their respective jurisdictions of formation and are qualified and licensed to do
business and are in good standing in any jurisdiction in which the conduct of their business or their ownership of property requires that they be qualified except where the failure to do so could not reasonably be expected to have a Material Adverse
Change. In connection with this Agreement, Borrower has delivered to Agent a completed certificate signed by Borrower, entitled “Perfection Certificate”. Borrower represents and warrants that (a) Borrower’s exact legal name is
that indicated on the Perfection Certificate and on the signature page hereof; (b) Borrower is an organization of the type and is organized in the jurisdiction set forth in the Perfection Certificate; (c) the Perfection Certificate
accurately sets forth Borrower’s organizational identification number or accurately states that Borrower has none; (d) the Perfection Certificate accurately sets forth Borrower’s place of business, or, if more than one, its chief
executive office as well as Borrower’s mailing address 

  
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(if different than its chief executive office); (e) Except for Borrower’s re-incorporation into Delaware, Borrower (and each of its predecessors) has not, in the past five
(5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction; and (f) all other information set forth on the Perfection Certificate pertaining to Borrower and
each of its Subsidiaries is accurate and complete (it being understood and agreed that Borrower may from time to time update certain information in the Perfection Certificate after the Effective Date to the extent permitted by one or more specific
provisions in this Agreement). If Borrower is not now a Registered Organization but later becomes one, Borrower shall promptly notify Agent of such occurrence and provide Agent with Borrower’s organizational identification number if an
organizational identification number is issued. 
 The execution, delivery and performance by Borrower of the Loan Documents to
which it is a party have been duly authorized, and do not (i) conflict with any of Borrower’s organizational documents, (ii) contravene, conflict with, constitute a default under or violate any Requirement of Law,
(iii) contravene, conflict or violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which Borrower or any of its Subsidiaries or any of their property or assets may be bound or
affected, (iv) require any action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority (except such Governmental Approvals which have already been obtained and are in full force and effect
or (v) constitute an event of default under any agreement by which Borrower of any of its Subsidiaries or their respective properties is bound, except, in the cases of subsections (ii) or (v) above, as could not be reasonably expected
to have a Material Adverse Change. Borrower is not in default under any agreement to which it is a party or by which it is bound in which the default could reasonably be expected to have a Material Adverse Change. 

5.2 Collateral. 
 (a) Borrower has good title to, has rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien hereunder, free and clear of any and all Liens except Permitted
Liens. Borrower has no Deposit Accounts, Securities Accounts, Commodity Accounts or other investment accounts other than (i) the Collateral Accounts described in the Perfection Certificate delivered to Agent in connection herewith, or of which
Borrower has given Agent notice and taken such actions as are necessary to give Agent a perfected security interest therein and (ii) the Excluded Accounts described in the Perfection Certificate delivered to Agent in connection herewith.

 (b) The Collateral is not in the possession of any third party bailee (such as a warehouse) except as otherwise provided in
the Perfection Certificate. None of the components of the Collateral (other than consigned inventory held with Borrower’s customers) with an aggregate value in excess of One Hundred Thousand Dollars ($100,000) shall be maintained at locations
other than as provided in the Perfection Certificate (as may be updated from time to time with the written consent of Agent) or as permitted pursuant to Section 7.2. 
 (c) Borrower is the sole owner of the Intellectual Property which it owns or purports to own except for (a) non-exclusive licenses granted to its customers in the Ordinary Course of Business,
(b) over-the-counter software that is commercially available to the public, and (c) material Intellectual Property licensed to Borrower and noted on the Perfection Certificate. Each Patent which it owns or purports to own and which
constitutes Core Intellectual Property is valid and enforceable, and no part of the Intellectual Property which Borrower owns or purports to own and which is material to Borrower’s business has been judged invalid or unenforceable, in whole or
in part. Except for claims made in the Palomar Litigation, to Borrower’s knowledge, no claim has been made that any part of the Intellectual Property violates the rights of any third party except to the extent such claim would not reasonably be
expected to have a Material Adverse Change. 
 (d) Except as noted on the Perfection Certificate and any license entered into in
connection with the resolution of the litigation, whether by settlement, judgment or otherwise directly relating to the Palomar Litigation, Borrower is not a party to, nor is it bound by, any Restricted License. 

  
 8 

 5.3 Intentionally Omitted. 

5.4 Litigation. Other than the Palomar Litigation, there are no actions or proceedings pending or, to the knowledge of the
Borrower, threatened in writing by or against Borrower or any of its Subsidiaries involving more than, individually or in the aggregate, Two Hundred Fifty Thousand Dollars ($250,000). 

5.5 Financial Statements; Financial Condition. All consolidated financial statements for Borrower and any of its
Subsidiaries delivered to Agent fairly present, in conformity with GAAP, in all material respects Borrower’s consolidated financial condition and Borrower’s consolidated results of operations. There has not been any material deterioration
in Borrower’s consolidated financial condition since the date of the most recent financial statements and projections submitted to Agent. 
 5.6 Solvency. Before and after giving effect to the transactions described in this Agreement, (a) Borrower is not left with unreasonably small capital in relation to its business as
presently conducted; (b) the fair salable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities and (c) Borrower is able to pay its debts (including trade debts) as they
mature. 
 5.7 Compliance with Laws; Regulatory Compliance. 

(a) Borrower is not an “investment company” or a company “controlled” by an “investment company” under the
Investment Company Act of 1940, as amended. Borrower is not engaged as one of its important activities in extending credit for margin stock (under Regulations X, T and U of the Federal Reserve Board of Governors). As of the Effective Date, except as
set forth on Schedule B, neither Borrower nor any Subsidiary of Borrower owns any such margin stock. Borrower has complied in all material respects with the Federal Fair Labor Standards Act. Neither Borrower nor any of its Subsidiaries is a
“holding company” or an “affiliate” of a “holding company” or a “subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005.
Borrower has not violated any Laws, ordinances or rules, the violation of which could reasonably be expected to have a Material Adverse Change. None of Borrower’s or any of its Subsidiaries’ properties or assets has been used by Borrower
or any Subsidiary or, to the Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than in material compliance with applicable Laws. Borrower and each of its
Subsidiaries have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all Government Authorities that are necessary to continue their respective businesses as currently conducted,
other than such consents, approvals and authorizations, the failure of which to obtain could not reasonably be expected to have a Material Adverse Change. 
 (b) Neither the Borrower nor, to the knowledge of Borrower, any of its Affiliates or any of their respective agents acting or benefiting in any capacity in connection with the transactions contemplated by
this Agreement is (i) in violation of any Anti-Terrorism Law, (ii) engages in or conspires to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding or attempts to violate, any of the prohibitions set
forth in any Anti-Terrorism Law, or (iii) is a Blocked Person. Neither Borrower nor, to the knowledge of Borrower, any of its Affiliates or agents acting or benefiting in any capacity in connection with the transactions contemplated by this
Agreement, (x) conducts any business or engages in making or receiving any contribution of funds, goods or services to or for the benefit of any Blocked Person, or (y) deals in, or otherwise engages in any transaction relating to, any
property or interest in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law. 
 5.8 Subsidiaries; Investments. Borrower does not own any stock, partnership interest or other equity securities except for Permitted Investments or as otherwise disclosed on the Perfection
Certificate. 
 5.9 Tax Returns and Payments; Pension Contributions. Borrower and its Material Subsidiaries have
timely filed all federal and material foreign, state and local tax returns and reports, such returns and reports are accurate and complete in all material respects, and Borrower and its Material Subsidiaries have timely paid all federal and material
foreign, state and local taxes, assessments, deposits and contributions owed by Borrower, unless (a) such taxes are being contested in good faith by appropriate proceedings promptly and diligently instituted and conducted and (b) Borrower
or its applicable Material Subsidiary posts bonds or takes any other steps required to prevent the Governmental Authority levying such contested taxes from obtaining a Lien upon any of the Collateral that is other than a “Permitted Lien”.
Borrower is unaware of any claims or adjustments proposed for any of 

  
 9 

 
Borrower’s prior tax years which could result in additional material taxes becoming due and payable by Borrower. Borrower has paid all amounts necessary to fund all present pension, profit
sharing and deferred compensation plans in accordance with their terms, and Borrower has not withdrawn from participation in, and has not permitted partial or complete termination of, or permitted the occurrence of any other event with respect to,
any such plan which could reasonably be expected to result in any liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency, in each case, other than such payments
which the failure to make could not reasonably be expected to result in liability to Borrower in the aggregate of $250,000 or more or result in a Lien against Borrower or any of its Subsidiaries. 

5.10 Use of Proceeds. Borrower shall use the proceeds of the Credit Extensions solely as working capital and to fund its
general business requirements and not for personal, family, household or agricultural purposes. A portion of the proceeds of the initial Credit Extension shall be used on the Effective Date to repay in full the Existing SVB Indebtedness. 

5.11 Full Disclosure. No written representation, warranty or other statement of Borrower in any certificate or written
statement given to Agent or any Lender, as of the date such representation, warranty, or other statement was made, taken together with all such written certificates and written statements given to Agent or any Lender, contains any untrue statement
of a material fact or omits to state a material fact necessary to make the statements contained in the certificates or statements not misleading (it being recognized that the projections and forecasts provided by Borrower in good faith and based
upon reasonable assumptions are not viewed as facts and that actual results during the period or periods covered by such projections and forecasts may differ from the projected or forecasted results). 

5.12 Definition of “Knowledge.” For purposes of the Loan Documents, whenever a representation or warranty
is made to Borrower’s knowledge or awareness, to the “best of” Borrower’s knowledge, or with a similar qualification, knowledge or awareness means the actual knowledge, after reasonable investigation, of the Responsible Officers

 5.13 Products and Required Permits. All Products and all Required Permits are listed in the Perfection
Certificate (as updated from time to time in accordance with this Agreement). 
  

	 	6	AFFIRMATIVE COVENANTS 

 Borrower shall do all of the following: 
 6.1 Government Compliance.

 (a) Maintain its and all its Subsidiaries’ legal existence and good standing in their respective jurisdictions of
formation and maintain qualification in each jurisdiction in which the failure to so qualify could reasonably be expected to have a Material Adverse Change. Borrower shall comply, and have each Subsidiary comply, with all Laws, ordinances and
regulations to which it is subject, the noncompliance with which could reasonably be expected to have a Material Adverse Change. 
 (b) Obtain and keep in full force and effect all of the Governmental Approvals necessary for the performance by Borrower of its obligations under the Loan Documents to which it is a party and the grant of
a security interest to Agent, for the ratable benefit of the Lenders, in the Collateral, other than such Governmental Approvals the failure of which to possess could not reasonably be expected to have a Material Adverse Change. Borrower shall
promptly provide copies of any such obtained Governmental Approvals to Agent upon request by Agent or a Lender. 
 6.2
Financial Statements, Reports, Certificates. 
 (a) Deliver to Agent and the Lenders: (i) as soon as available,
but no later than thirty (30) days after the last day of each month, company prepared consolidated and consolidating financial statements covering the consolidated operations of Borrower and its Subsidiaries for such period in the form provided
to the 

  
 10 

 
Major Investors of Borrower (which, for the avoidance of doubt, shall include consolidated and consolidating balance sheets, income statements and statements of cash flow) and an accounts
receivable aging and account payable aging; (ii) as soon as available, but no later than one hundred twenty (120) days after the last day of Borrower’s fiscal year, audited consolidated and consolidating financial statements prepared
under GAAP, consistently applied, together with an unqualified opinion on the financial statements from an independent certified public accounting firm of national standing selected by Borrower; (iii) as soon as available after approval thereof
by Borrower’s Board of Directors, but no later than the earlier of (A) January 31 of each calendar year or (B) seven (7) days after such approval, Borrower’s annual budget and financial projections as approved by
Borrower’s Board of Directors, which shall be in the form provided to the Major Investors of Borrower (iv) within five (5) days of delivery, copies of all statements, reports and notices made available to Borrower’s security
holders or holders of Subordinated Debt; and (v) in the event that Borrower becomes subject to the reporting requirements under the Securities Exchange Act of 1934, as amended, within five (5) days of filing, all reports on Form 10-K, 10-Q
and 8 K filed with the Securities and Exchange Commission or a link thereto on Borrower’s or another website on the Internet; (vi) a prompt report of any legal actions pending or threatened against Borrower or any of its Subsidiaries that
could reasonably be expected to result in damages or costs to Borrower or any of its Subsidiaries of Two Hundred and Fifty Thousand Dollars ($250,000) or more or could result in a Material Adverse Change; and (vii) budgets, sales projections,
operating plans and other financial information reasonably requested by Agent. 
 (b) Concurrently with the delivery of the
financial statements specified in Section 6.2(a)(i) above but no later than thirty (30) days after the last day of each month, deliver to Agent, a duly completed Compliance Certificate signed by a Responsible Officer. 

(c) Keep proper books of record and account in accordance with GAAP in all material respects, in which full, true and correct entries
shall be made of all dealings and transactions in relation to its business and activities. Borrower shall allow, at the sole cost of Borrower, Agent and the Lenders, during regular business hours upon reasonable prior notice (except while an Event
of Default has occurred and is continuing) up to twice per year, (i) to visit and inspect any of its properties in a reasonable manner, to examine and make abstracts or copies from any of Borrower’s Books, and (ii) to conduct a
reasonable collateral audit and analysis of its operations and the Collateral (provided that Borrower shall not be obligated to provide access to or disclose any information that is expressly prohibited to be disclosed by applicable federal or state
Law or by a court order or decree; provided, however, that, to the extent that any such court order or decree has been issued pursuant to a consent order requested by the parties to any such litigation such consent order shall
include express permission to disclose any such consent order or court order or decree to Agent and Lenders in accordance with this Agreement, including for the avoidance of doubt, Section 12.9) to verify the amount and age of the accounts, the
identity and credit of the respective account debtors, to review the billing practices of Borrower and to discuss its respective affairs, finances and accounts with their respective officers, employees and independent public accountants;
provided that Borrower shall only be required to make commercially reasonable efforts to include the independent public accountants. Notwithstanding the foregoing, if an Event of Default has occurred and is continuing, Agent and the
Lenders may exercise its rights under this Section 6.2 any number of times per year. 
 (d) Within ten (10) days of
(i) acquiring and/or developing any new Intellectual Property or (ii) entering or becoming bound by any additional license agreement (other than over-the-counter software that is commercially available to the public) and within three
(3) days of any other material change in Borrower’s Intellectual Property from that listed on Perfection Certificate, deliver to Agent an updated Perfection Certificate reflecting same. Borrower shall take such commercially reasonable
steps as Agent requests to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for (x) all licenses or agreements to be deemed “Collateral” and for Agent to have a security interest in it that might
otherwise be restricted or prohibited by Law or by the terms of any such license or agreement, whether now existing or entered into in the future, and (y) Agent to have the ability in the event of a liquidation of any Collateral to dispose of
such Collateral in accordance with Agent’s rights and remedies under this Agreement and the other Loan Documents; provided that Borrower shall not be required to obtain such consent or waiver required pursuant to this sentence with respect to
any licenses granted in connection with the Palomar Litigation. 
 (e) If, after the Effective Date, Borrower determines to
manufacture, sell, develop, test or market any new Product, Borrower shall give prior written notice to Agent of such determination (which shall include a brief description of such Product, plus a list of all Required Permits relating to such new
Product (and a 

  
 11 

 
copy of such Required Permits if requested by Agent) and/or Borrower’s manufacture, sale, development, testing or marketing thereof issued or outstanding as of the date of such notice),
along with a copy of an updated Perfection Certificate; provided, however, that if Borrower shall at any time obtain any new or additional Required Permits from the FDA, DEA, or parallel state or local authorities, or foreign counterparts of the
FDA, DEA, or parallel state or local authorities, with respect to any Product which has previously been disclosed to Agent, Borrower shall promptly give written notice to Agent of such new or additional Required Permits (along with a copy thereof if
requested by Agent). 
 6.3 Inventory; Returns. Keep all Inventory in good and marketable condition in all
material respects, free from material defects. Returns and allowances between Borrower and its Account Debtors shall follow Borrower’s customary practices as they exist at the Effective Date. Borrower must promptly notify Agent of all returns,
recoveries, disputes and claims outside the Ordinary Course of Business or not consistent with past practices. 
 6.4 Taxes;
Pensions. Timely file, and require each of its Material Subsidiaries to timely file, all federal and material foreign, state and local tax returns and reports and timely pay, and require each of its Material Subsidiaries to timely pay,
all federal and material foreign state and local taxes, assessments, deposits and contributions owed by Borrower and each of its Subsidiaries, except for deferred payment of any taxes contested pursuant to the terms of Section 5.9 hereof, and
pay all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their terms. 
 6.5 Insurance. Keep its business and the Collateral insured for risks and in amounts standard for companies in Borrower’s industry and location. Insurance policies shall be in a form,
with companies, and in amounts that are reasonably satisfactory to Agent and consistent with the general practices of businesses engaged in similar activities in similar geographic areas. All property policies shall have a lender’s loss payable
endorsement showing Agent as a lender loss payee and waive subrogation against Agent. All liability policies shall show, or have endorsements showing, Agent as an additional insured. All policies (or their respective endorsements) shall provide that
the insurer shall give Agent at least twenty (20) days notice before canceling, materially and adversely amending, or declining to renew its policy. At Agent’s request, Borrower shall deliver certified copies of policies and evidence of
all premium payments. Proceeds payable under any policy shall, at Agent’s option, be payable to Agent on behalf of the Lenders on account of the Obligations. Notwithstanding the foregoing, so long as no Event of Default has occurred and is
continuing, Borrower shall have the option of applying the proceeds of any casualty policy toward the replacement or repair of destroyed or damaged property within six (6) months following the receipt of such proceeds; provided that
(i) Borrower shall provide written notice to Agent of the occurrence of any such event that results in the receipt of such insurance proceeds and provide subsequent written notice to Agent detailing the amount of the proceeds received and the
replacement or repair information relating to such reinvestment and (ii) any such replaced or repaired property (A) shall be of equal or like value as the replaced or repaired Collateral and (B) shall be deemed Collateral in which
Agent and Lenders have been granted a first priority security interest and Borrower shall execute all instruments and take all further action as Agent reasonably requests to perfect Agent’s Lien in such Collateral. If Borrower fails to obtain
insurance as required under this Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and Agent, Agent may make all or part of such payment or obtain such insurance policies required in this
Section 6.5, and take any action under the policies Agent deems prudent. 
 6.6 Operating Accounts.

 (a) Maintain its and its Credit Party Subsidiaries’ primary operating and other Deposit Accounts and Securities Accounts
with SVB. 
 (b) Provide Agent prompt notice, but in any event within five (5) days, of establishing any Collateral Account
at or with any bank or financial institution other than SVB. For each Collateral Account that Borrower at any time maintains, Borrower shall cause the applicable bank or financial institution (other than SVB) at or with which any Collateral Account
is maintained to, prior to funding any such Collateral Accounts, execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect Agent’s Lien in such Collateral Account in accordance
with the terms hereunder which Control Agreement may not be terminated without the prior written consent of Agent. The provisions of the previous sentence shall not apply to the Excluded Accounts. 

  
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 6.7 Financial Covenant. Commencing with the month ending December 31,
2011, and continuing as of the last day of each calendar month thereafter, have minimum Net Sales, tested as of the last day of each month for the prior twelve month period of at least the minimum Net Sales agreed upon in writing by the parties
hereto. 
 6.8 Protection of Core Intellectual Property Rights. (i) Protect, defend and maintain the validity
and enforceability of its Core Intellectual Property; (ii) promptly advise Agent in writing of material infringements of its Core Intellectual Property; and (iii) not allow any Core Intellectual Property to be abandoned, forfeited or
dedicated to the public without Agent’s and the Required Lenders’ written consent. 
 6.9 Litigation
Cooperation. From the date hereof and continuing through the termination of this Agreement, make available to Agent, without expense to Agent, Borrower and its officers, employees and agents and Borrower’s Books, to the extent that
Agent may deem them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Agent with respect to any Collateral or relating to Borrower; provided that Borrower and its Subsidiaries shall not be
obligated to disclose pursuant to this Section 6.9 any communication covered by attorney client privilege the disclosure of which could cause the Borrower or its Subsidiaries to lose such attorney client privilege; provided,
however, that any factual information contained in such attorney-client privileged communication shall be separated therefrom and disclosed to Agent and Lenders. 
 6.10 Notices of Litigation, Regulatory Matters and Default. Borrower will give prompt written notice to Agent of any litigation or governmental proceedings (including pending or threatened (in
writing) against Borrower which could reasonably be expected to have a Material Adverse Change. Borrower shall give prompt written notice to Agent of any notices, communication or other correspondence from or with and Governmental Authority
(including the FDA) indicating that (i) such Governmental Authority is conducting an investigation, inspection or review of any of Borrower’s Products or Required Permits, or any facilities and/or processes related thereto (other than
routine inspections), (ii) any such investigation, inspection or review referenced in clause (i) has resulted in or disclosed any material deficiencies or violations of Laws and/or any Required Permits, (iii) any Required Permit has
been revoked or withdrawn or (iv) such Governmental Authority has ordered or recommended that the development, testing and/or manufacturing of any Product should cease. Without limiting or contradicting any other more specific provision of this
Agreement, promptly (and in any event within three (3) Business Days) upon (i) Borrower becoming aware of the existence of any Event of Default or (ii) any Responsible Officer of Borrower becoming aware of the existence of any event
which, with the giving of notice or passage of time, or both, would constitute an Event of Default, in each case, Borrower shall give written notice to Agent of such occurrence, which such notice shall include a reasonably detailed description of
such Event of Default or event which, with the giving of notice or passage of time, or both, would constitute an Event of Default. 
 6.11 Creation/Acquisition of Subsidiaries. In the event Borrower or any Subsidiary creates or , to the extent permitted hereunder, acquires any Subsidiary, Borrower and such Subsidiary shall
promptly notify Agent of the creation or acquisition of such new Subsidiary and take, within ninety (90) days, all such action as may be reasonably required by Agent to cause each such Subsidiary, if such Subsidiary is not a Foreign Subsidiary,
to become a co-Borrower hereunder or to guarantee the Obligations of Borrower under the Loan Documents and, in each case, grant a continuing pledge and security interest in and to the assets of such Subsidiary (substantially as described on
Exhibit A hereto). Borrower shall grant and pledge to Agent, for the ratable benefit of the Lenders, a perfected security interest in the Shares of each Subsidiary; provided however, that with respect to Foreign Subsidiaries,
Foreign Share Pledge Documents will only be required for Tria Japan, Tria Korea, Tria U.K. and any other Foreign Subsidiaries that constitute a Material Subsidiary. To the extent a Foreign Subsidiary becomes a Material Subsidiary following the
Effective Date, the Borrower shall have ninety (90) days following the delivery of Borrower’s monthly financial statements to the Agent pursuant to Section 6.2(a)(i) hereof to deliver the Foreign Share Pledge Documents for such
Material Subsidiary to the Agent. 
 6.12 Further Assurances. Execute any further instruments and take further
action as Agent reasonably requests to perfect or continue Agent’s Lien in the Collateral or to effect the purposes of this Agreement. Deliver to Agent, in a timely manner, copies of all material correspondence, reports, documents and other
filings with any Governmental Authority that could reasonably be expected to have a Material Adverse Change, except to 

  
 13 

 
the extent that such correspondence, reports, documents or other filings are (i) subject to attorney client privilege and their disclosure could cause the Borrower or its Subsidiaries to
lose such attorney client privilege; provided, however, that any factual information contained in such attorney-client privileged communication shall be separated therefrom and disclosed to Agent and Lenders or (ii) expressly
prohibited to be disclosed by applicable federal or state Law or by a court order or decree; provided, however, that, to the extent that any such court order or decree has been issued pursuant to a consent order requested by the
parties to any such litigation such consent order shall include express permission to disclose any such consent order or court order or decree to Agent and Lenders in accordance with this Agreement, including for the avoidance of doubt,
Section 12.9 
 6.13 Post-Closing Obligations. Borrower shall complete each of the post closing obligations
and/or deliver to Agent each of the documents, instruments, agreements and information set forth in Section 3.3, on or before the date set forth for each such item thereon, each of which shall be completed or provided in form and substance
reasonably satisfactory to Agent and Lenders. 
  

	 	7	NEGATIVE COVENANTS 

Borrower shall not and shall not permit any of its Subsidiaries to do any of the following without the prior written consent of Agent and
the Required Lenders: 
 7.1 Dispositions. Convey, sell, lease, transfer, assign, grant a security interest in or
otherwise dispose of (collectively, “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property (including without limitation the Intellectual Property and Collateral of Borrower), except
for Transfers (a) of Inventory in the Ordinary Course of Business and the payment of cash for services rendered in the Ordinary Course of Business, including by Borrower to a Subsidiary or Affiliate of Borrower, or by a Subsidiary of Borrower
to Borrower, another Subsidiary of Borrower or an Affiliate of Borrower, subject at all times, in the case of any such payments made between Borrower and its Subsidiaries and Affiliates to the requirements set forth in Section 7.8; (b) of
worn-out or obsolete Equipment; (c) to the extent the same constitutes a Transfer, in connection with Permitted Liens and Permitted Investments; (d) of non-exclusive licenses for the use of the Intellectual Property of Borrower and its
Subsidiaries (i) in the Ordinary Course of Business in connection with joint ventures and corporate collaborations and (ii) in connection with the resolution of the litigation, whether by settlement, judgment or otherwise directly relating
to the Palomar Litigation; and, (e) of Intellectual Property that is not Core Intellectual Property that have been approved by Borrower’s Board of Directors (provided that Borrower shall provide Agent prompt notice of any such Transfer).

 7.2 Changes in Business, Management, Ownership, or Business Locations. (a) Engage in or permit any of its
Subsidiaries to engage in any business other than the businesses engaged in or anticipated to be engaged in by Borrower as of the Effective Date or reasonably related thereto; (b) liquidate or dissolve; or (c) (i) the Key Person shall
cease to be actively engaged in the management of Borrower unless a replacement for the Key Person is approved by Borrower’s Board of Directors and engaged by Borrower within ninety (90) days, or (ii) enter into any transaction or
series of related transactions in which a Change in Control occurs. Borrower shall not, without at least five (5) Business Days prior written notice to Agent: (A) change its jurisdiction of organization, (B) change its organizational
structure or type, (C) change its legal name, or (D) change any organizational number (if any) assigned by its jurisdiction of organization. Borrower shall not, without providing prompt written notice to Agent, add any new offices or
business locations, including warehouses (unless such new offices or business locations contain less than One Hundred Thousand Dollars ($100,000) in Borrower’s assets or property). Borrower shall not, after the Effective Date, store or
otherwise deliver any portion of the Collateral (other than consigned inventory held with Borrower’s customers) to a bailee with an aggregate value in excess of One Hundred Thousand Dollars ($100,000) unless such bailee first executes and
delivers a bailee agreement in form and substance reasonably satisfactory to Agent. 
 7.3 Mergers or
Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock, shares or
property of another Person except that: (a) Borrower or any of its Subsidiaries shall be permitted to acquire all or substantially all of the capital stock, shares or property of another Person so long as
(i)

  
 14 

 
total cash consideration (which shall include all earn-out payments, deferred purchase price payments and other similar payments) for all such transactions does not in the aggregate exceed One
Million Dollars ($1,000,000) in any fiscal year of Borrower; (ii) Borrower, or Borrower’s Subsidiary, as applicable, is the surviving legal entity; (iii) Borrower and Borrower’s Subsidiary is in compliance with Section 6.11
(for the avoidance of doubt, the calculation of the total consideration for transactions referenced in clause (a)(i) shall not include any consideration consisting of the capital stock of Borrower); (iv) Borrower shall give written notice of
such proposed acquisition and furnish to Agent and Lenders, in each case, at least fifteen (15) days prior to the consummation thereof (A) an executed term sheet and/or letter of intent (setting forth in reasonable detail the terms and
conditions of such acquisition) and, at the request of Agent, such other information and documents that Agent may request, including, without limitation, executed counterparts of the respective agreements, documents or instruments pursuant to which
such acquisition is to be consummated and (B) copies of such other agreements, instruments and other documents related to such acquisition as Agent reasonably shall request; (v) such acquisition shall not be hostile and shall have been
approved by the board of directors (or other similar body) and/or the stockholders or other equityholders of such Person; (vi) no Default or Event of Default shall then exist or would exist after giving effect thereto; (vii) there shall be
no Indebtedness or liabilities incurred, assumed and/or reflected on a consolidated balance sheet of Borrower and its Subsidiaries after giving effect to such acquisition other than Permitted Indebtedness and (viii) all assets being acquired in
connection therewith shall be free and clear of all Liens other than Permitted Liens and (b) any Subsidiary may merge or consolidate into a Credit Party Subsidiary or into Borrower so long as (i) Borrower or such Credit Party Subsidiary,
as applicable, shall be the surviving legal entity and (ii) Borrower’s tangible net worth is not thereby reduced; provided that no such transaction shall be permitted unless (X) Borrower has provided Agent with seven (7) Business
Days prior written notice of such transaction and (Y) no Event of Default is occurring and is continuing prior thereto or would exist after giving effect to such transaction. 

7.4 Indebtedness. Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than
Permitted Indebtedness. 
 7.5 Encumbrance. (a) Create, incur, allow, or suffer any Lien on any of its
property, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, (b) permit any Collateral not to be subject to the first priority security
interest granted herein (except for Permitted Liens that have priority to Agent’s Liens solely by operation of applicable Law or as otherwise consented to by Agent), (c) enter into any agreement, document, instrument or other arrangement
(except with or in favor of Agent) with any Person which directly or indirectly prohibits or has the effect of prohibiting Borrower or any Subsidiary from assigning, mortgaging, pledging, granting a security interest in or upon, (d) except as
is otherwise permitted in Section 7.1 hereof and the definition of “Permitted Liens” herein, encumbering any of Borrower’s or any Subsidiary’s Intellectual Property or (e) enter or become bound by any Restricted License
(other than any license entered into in connection with the resolution of the litigation, whether by settlement, judgment or otherwise, directly relating to the Palomar Litigation or any over-the-counter software that is commercially available to
the public). 
 7.6 Maintenance of Collateral Accounts. Maintain any Collateral Account except pursuant to the
terms of Section 6.6 hereof. For the avoidance of doubt, nothing in this Agreement shall prohibit or restrict Deposit Accounts, Securities Accounts or Commodities Accounts held by the Subsidiaries of the Borrower that are Foreign Subsidiaries.

 7.7 Distributions; Investments. (a) Pay any dividends (other than dividends payable solely in common
stock) or make any distribution or payment or redeem, retire or purchase any capital stock (other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements, stockholder rights plans, director or
consultant stock option plans, or similar plans, provided such repurchases do not exceed Five Hundred Thousand Dollars ($500,000) in the aggregate per fiscal year) or (b) directly or indirectly make any Investment other than Permitted
Investments, or permit any of its Subsidiaries to do so; provided, that, Agent and Lenders agree that consent to any request by Borrower to make additional reasonable Investments for reasonable business purposes in its Subsidiaries whose
Shares have been pledged to the Agent for itself and the benefit of the Lenders in accordance with the terms of this Agreement shall not be unreasonably withheld. 
 7.8 Transactions with Affiliates. Directly or indirectly enter into or permit to exist any material transaction with any Affiliate of Borrower, except for transactions that are in the
Ordinary Course of Business, upon 

  
 15 

 
fair and reasonable terms that are no less favorable to Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person and transactions between or among Borrower
and one or more of its Subsidiaries that are not otherwise prohibited hereunder. 
 7.9 Subordinated Debt. Make or
permit any payment on any Subordinated Debt or amend or otherwise modify any provision in any document relating to the Subordinated Debt, except as expressly permitted pursuant to the terms of such intercreditor, subordination or other similar
agreement that such Subordinated Debt is subject to. 
 7.10 Compliance. Become an “investment company”
or a company controlled by an “investment company”, under the Investment Company Act of 1940, as amended or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the
Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction (as defined in ERISA) to
occur, in each cases, which could reasonably be expected to result in liability to Borrower or its Subsidiaries in an aggregate amount of $250,000 or more or result in a Lien against Borrower or any of its Subsidiaries; fail to comply with the
Federal Fair Labor Standards Act or violate any other Law or regulation, if the violation could reasonably be expected to have a Material Adverse Change, or permit any of its Subsidiaries to do so; withdraw or permit any Subsidiary to withdraw from
participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan which could reasonably be expected to result in any
liability of Borrower, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency. 
 7.11 Compliance with Anti-Terrorism Laws. Agent hereby notifies Borrower that pursuant to the requirements of Anti-Terrorism Laws, and Agent’s policies and practices, Agent is required
to obtain, verify and record certain information and documentation that identifies Borrower and its principals, which information includes the name and address of Borrower and its principals and such other information that will allow Agent to
identify such party in accordance with Anti-Terrorism Laws. Borrower will not, nor will Borrower permit any Subsidiary or Affiliate to, directly or indirectly, knowingly enter into any documents, instruments, agreements or contracts with any Person
listed on the OFAC Lists. Borrower shall immediately notify Agent if Borrower has knowledge that Borrower or any Subsidiary or Affiliate is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is
indicted on, or (d) is arraigned and held over on charges involving money laundering or predicate crimes to money laundering. Borrower will not, nor will Borrower permit any Subsidiary or Affiliate to, directly or indirectly, (i) conduct
any business or engage in any transaction or dealing with any Blocked Person, including, without limitation, the making or receiving of any contribution of funds, goods or services to or for the benefit of any Blocked Person, (ii) deal in, or
otherwise engage in any transaction relating to, any property or interests in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any
transaction that evades or avoids, or has the purpose of evading or avoiding, or attempts to violate, any of the prohibitions set forth in Executive Order No. 13224 or other Anti-Terrorism Law. 

 

	 	8	EVENTS OF DEFAULT 

Any one of the following shall constitute an event of default (an “Event of Default”) under this Agreement: 

8.1 Payment Default. Borrower fails to (a) make any payment of principal or interest on any Credit Extension on its
due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three (3) Business Day cure period shall not apply to payments due on the Maturity Date or the date of
acceleration pursuant to Section 9.1(a) hereof). During the cure period, the failure to make or pay any payment specified under clause (a) or (b) hereunder is not an Event of Default (but no Credit Extension will be made during the
cure period); 

  
 16 

 8.2 Covenant Default. 

(a) Borrower fails or neglects to perform any obligation in Sections 6.1(a) (first sentence only), 6.2, 6.4, 6.5, 6.6, 6.7 or 6.12, 6.13
or violates any covenant in Section 7; or 
 (b) Borrower or any of its Subsidiaries fails or neglects to perform, keep, or
observe any other term, provision, condition, covenant or agreement contained in this Agreement or any Loan Documents to which it is party, and as to any default (other than those specified in this Section 8) under such other term, provision,
condition, covenant or agreement that can be cured, has failed to cure the default within ten (10) days after Borrower or any of its Subsidiaries becomes aware or should have become aware of the occurrence thereof; provided, however, that if
the default cannot by its nature be cured within the ten (10) day period or cannot after diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then Borrower
shall have an additional period (which shall not in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit
Extensions shall be made during such cure period). Cure periods provided under this section shall not apply, among other things, to financial covenants or any other covenants set forth in clause (a) above; 

8.3 Intentionally Deleted; 
 8.4 Attachment; Levy; Restraint on Business. 
 (a) (i) The service of
process seeking to attach, by trustee or similar process, any funds of Borrower or of any entity under the control of Borrower (including a Subsidiary) on deposit or otherwise maintained with, or subject to the control of, a Lender or any Affiliate
of a Lender, or (ii) a notice of lien, levy or assessment is filed against any of Borrower’s assets by any government agency, in the cases of subclauses (i) and (ii) where the value of any such funds or assets subject to such
attachment, notice of lien, levy or assessment is greater than or equal to $250,000 in the aggregate for all such circumstances and the same under subclauses (i) and (ii) hereof are not, within twenty (20) days after the occurrence
thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be made during any twenty (20) day cure period; or 

(b) (i) any material portion of Borrower’s assets is attached, seized, levied on, or comes into possession of a trustee or receiver,
or (ii) any court order enjoins, restrains, or prevents Borrower from conducting any material part of its business; 

8.5 Insolvency (a) Borrower is unable to pay its debts (including trade debts) as they become due or otherwise becomes
insolvent; (b) Borrower begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against Borrower and not dismissed or stayed within forty five (45) days (but no Credit Extensions shall be made while any of the
conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed); 
 8.6 Other
Agreements. There is, under any agreement to which Borrower or any Credit Party Subsidiary is a party with a third party or parties, any default (a) resulting in a right by such third party or parties, whether or not exercised, to
accelerate the maturity of any Indebtedness in an amount individually or in the aggregate in excess of Two Hundred Fifty Thousand Dollars ($250,000) or (b) that could have Material Adverse Change; 

8.7 Judgments. Except as may be otherwise agreed in writing by the parties hereto on the date of this Agreement or
thereafter, one or more judgments, orders, or decrees for the payment of money in an amount, individually or in the aggregate, of at least Two Hundred Fifty Thousand Dollars ($250,000) (not covered by independent third-party insurance as to which
liability has been accepted by such insurance carrier) shall be rendered against Borrower and the same are not, on or before the deadline specified by such order, or if no such deadline is specified, then within thirty (30) days after the entry
thereof, discharged or execution thereof stayed or bonded pending appeal, or such judgments are not discharged prior to the expiration of any such stay (provided that no Credit Extensions will be made prior to the discharge, stay, or bonding of such
judgment, order, or decree); 

  
 17 

 8.8 Misrepresentations. Borrower or any Person acting for Borrower makes any
representation, warranty, or other statement now or later in this Agreement, any Loan Document or in any writing delivered to Agent or any Lender or to induce Agent or any Lender to enter this Agreement or any Loan Document, and such representation,
warranty, or other statement is false or misleading in any material respect when made; 
 8.9 Subordinated Debt.
Any document, instrument, or agreement evidencing, or any subordination agreement relating to, any Subordinated Debt shall for any reason be revoked or invalidated or otherwise cease to be in full force and effect or the Obligations shall for any
reason be subordinated or shall not have the priority contemplated by this Agreement; 
 8.10 Investor
Abandonment. Agent or the Required Lenders determine in their good faith judgment that it is the clear intention of Borrower’s current investors or prospective investors to not continue to fund Borrower in the amounts and timeframe
necessary to enable Borrower to satisfy its financial obligations as they may become due and payable; 
 8.11 Change of
Control. A Change in Control occurs. 
 8.12 Governmental Approvals. Any Governmental Approval shall
have been (a) revoked, rescinded, suspended, modified in an adverse manner or not renewed in the Ordinary Course of Business for a full term, or (b) subject to any decision by a Governmental Authority that designates a hearing with respect
to any applications for renewal of any of such Governmental Approval or that could result in the Governmental Authority taking any of the actions described in clause (a) above, and such decision or such revocation, rescission, suspension,
modification or non-renewal has, or could reasonably be expected to have, a Material Adverse Change; or 
 8.13 Lien
Priority. Except as permitted by Agent or permitted pursuant to the terms of this Agreement, any Lien created hereunder or by any other Loan Document to which Borrower is a party shall at any time fail to constitute a valid and perfected
Lien on substantially all of the Collateral purported to be secured thereby, subject to no prior or equal Lien other than Permitted Liens that have priority to Agent’s Liens solely by operation of applicable law. 

 

	 	9	RIGHTS AND REMEDIES 

9.1 Rights and Remedies. While an Event of Default occurs and continues Agent may, and at the direction of the Required
Lenders shall, do any or all of the following: 
 (a) declare all Obligations immediately due and payable (but if an Event of
Default described in Section 8.5 occurs all Obligations are immediately due and payable without any action by Agent); 

(b) stop advancing money or extending credit for Borrower’s benefit under this Agreement or under any other agreement between
Borrower and Agent (but if an Event of Default described in Section 8.5 occurs all commitments and obligations to advance money or extend credit to Borrower on the part of Agent shall cease and terminate immediately without any action by Agent
and/or Lenders); 
 (c) notify each Lender to stop advancing money or extending credit for Borrower’s benefit under this
Agreement or under any other agreement between Borrower and the Lenders (but if an Event of Default described in Section 8.5 occurs all commitments and obligations to advance money or extend credit to Borrower on the part of any Lender shall
cease and terminate immediately without any action by Agent and/or Lenders); 
 (d) settle or adjust disputes and claims
directly with Account Debtors for amounts on terms and in any order that Agent considers advisable, notify any Person owing Borrower money of Agent’s security interest in such funds, and verify the amount of such account; 

(e) make any payments and do any acts it considers necessary or reasonable to protect the Collateral and/or its security interest in the
Collateral. Borrower shall assemble the Collateral if Agent requests and 

  
 18 

 
make it available as Agent designates. Agent may enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or
compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrower grants Agent a license to enter and occupy any of its premises, without charge, to exercise any of Agent’s rights or
remedies; 
 (f) apply to the Obligations any (a) balances and deposits of Borrower that Agent or any Lender holds or
controls, or (b) any amount held or controlled by Agent or any Lender owing to or for the credit or the account of Borrower; 
 (g) ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell the Collateral. Agent is hereby granted a non-exclusive, royalty-free license or other right to
use, without charge, Borrower’s labels, Patents, Copyrights, mask works, rights of use of any name, trade secrets, trade names, Trademarks, and advertising matter, or any similar property as it pertains to the Collateral, in completing
production of, advertising for sale, and selling any Collateral and, in connection with Agent’s exercise of its rights under this Section, Borrower’s rights under all licenses and all franchise agreements inure to Agent’s benefit;

 (h) place a “hold” on any account maintained with a Lender and/or deliver a notice of exclusive control, any
entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral; 
 (i) demand and receive possession of Borrower’s Books; 
 (j) foreclose upon
and/or sell or otherwise liquidate, the Collateral; 
 (k) commence and prosecute an Insolvency Proceeding or consent to
Borrower commencing any Insolvency Proceeding; and 
 (l) exercise all rights and remedies available to Agent or any Lender
under the Loan Documents or at law or equity, including all remedies provided under the Code (including disposal of the Collateral pursuant to the terms thereof). 
 9.2 Power of Attorney. Borrower hereby irrevocably appoints Agent as its lawful attorney-in-fact, exercisable upon the occurrence and during the continuance of an Event of Default, to:
(a) endorse Borrower’s name on any checks or other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and
claims about the Accounts directly with Account Debtors, for amounts and on terms Agent determines reasonable; (d) make, settle, and adjust all claims under Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge,
encumbrance, security interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; and (f) transfer the Collateral into the name of Agent or a third party
as the Code permits. Borrower hereby appoints Agent as its lawful attorney-in-fact to sign Borrower’s name on any documents necessary to perfect or continue the perfection of Agent’s security interest in the Collateral regardless of
whether an Event of Default has occurred until all Obligations have been satisfied in full and Agent and the Lenders are under no further obligation to make Credit Extensions hereunder. Agent’s foregoing appointment as Borrower’s attorney
in fact, and all of Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations have been fully repaid and performed and Agent’s and the Lenders’ obligation to provide Credit Extensions terminates.

 9.3 Protective Payments. If Borrower fails to obtain the insurance called for by Section 6.5, or fails to
pay any premium thereon , or fails to pay any other amount which Borrower is obligated to pay under this Agreement or any other Loan Document to which it is party or fails to pay any maintenance fees, extension fee or other fees or payments payable
to any Governmental Authority necessary to continue, maintain, preserve or protect any Intellectual Property of Borrower and its Subsidiaries and/or any rights and remedies of Borrower and its Subsidiaries with respect to such Intellectual Property,
Agent may obtain such insurance or make such payment, and all amounts so paid by Agent are Lender Expenses owing to Agent and immediately due and payable, bearing interest at the then highest rate applicable to the Obligations, and secured by the
Collateral. Agent will make reasonable efforts to provide Borrower with notice of Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by Agent are deemed an agreement to make similar payments
in the future or Agent’s or any Lender’s waiver of any Event of Default. 

  
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 9.4 Application of Payments and Proceeds Upon Default. Notwithstanding
anything to the contrary contained in this Agreement, upon the occurrence and during the continuance of an Event of Default, (a) Borrower irrevocably waives the right to direct the application of any and all payments at any time or times
thereafter received by Agent from or on behalf of Borrower of all or any part of the Obligations, and, as between Borrower on the one hand and Agent and Lenders on the other, Agent shall have the continuing and exclusive right to apply and to
reapply any and all payments received against the Obligations in such manner as Agent may deem advisable notwithstanding any previous application by Agent, and (b) the proceeds of any sale of, or other realization upon all or any part of the
Collateral shall be applied: first, to the Lender Expenses; second, to accrued and unpaid interest on the Obligations (including any interest which, but for the provisions of the United States Bankruptcy Code, would have accrued on such amounts);
third, to the principal amount of the Obligations outstanding; and fourth, to any other indebtedness or obligations of Borrower owing to Agent or any Lender under the Loan Documents. Any balance remaining shall be delivered to Borrower or to whoever
may be lawfully entitled to receive such balance or as a court of competent jurisdiction may direct. In carrying out the foregoing, (x) amounts received shall be applied in the numerical order provided until exhausted prior to the application
to the next succeeding category, and (y) each of the Persons entitled to receive a payment in any particular category shall receive an amount equal to its pro rata share of amounts available to be applied pursuant thereto for such category. Any
reference in this Agreement to an allocation between or sharing by the Lenders of any right, interest or obligation “ratably,” “proportionally” or in similar terms shall refer to Pro Rata Share unless expressly provided
otherwise. Agent, or if applicable, each Lender, shall promptly remit to the other Lenders such sums as may be necessary to ensure the ratable repayment of each Lender’s portion of any Term Loan and the ratable distribution of interest, fees
and reimbursements paid or made by Borrower. Notwithstanding the foregoing, a Lender receiving a scheduled payment shall not be responsible for determining whether the other Lenders also received their scheduled payment on such date; provided,
however, if it is later determined that a Lender received more than its ratable share of scheduled payments made on any date or dates, then such Lender shall remit to the Agent or other Lenders such sums as may be necessary to ensure the ratable
payment of such scheduled payments, as instructed by Agent. Any payment or distribution of any kind or character, whether in cash, properties or securities, shall be received by a Lender in excess of its ratable share, then the portion of such
payment or distribution in excess of such Lender’s ratable share shall be received by such Lender in trust for and shall be promptly paid over to the other Lender for application to the payments of amounts due on the other Lender’s claims.
To the extent any payment for the account of Borrower is required to be returned as a voidable transfer or otherwise, the Lenders shall contribute to one another as is necessary to ensure that such return of payment is on a pro rata basis. If any
Lender shall obtain possession of any Collateral, it shall hold such Collateral for itself and as agent and bailee for the Agent and other Lenders for purposes of perfecting Agent’s security interest therein. Notwithstanding anything to the
contrary herein, any warrants issued to the Lenders by Borrower, the stock issuable thereunder, any equity securities purchased by Lenders, any amounts paid thereunder, any dividends, and any other rights in connection therewith shall not be subject
to the terms and conditions of this Agreement. Nothing herein shall affect any Lender’s rights under any such warrants, stock, or other equity securities to administer, manage, transfer, assign, or exercise such warrants, stock, or other equity
securities for its own account. 
 9.5 Liability for Collateral. So long as Agent complies with reasonable banking
practices regarding the safekeeping of the Collateral in the possession or under the control of Agent, Agent shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral;
(c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrower bears all risk of loss, damage or destruction of the Collateral. 

9.6 No Waiver; Remedies Cumulative. Agent’s and/or any Lender’s failure, at any time or times, to require strict
performance by Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Agent, for the benefit of Lenders, thereafter to demand strict performance and compliance herewith or therewith.
No waiver hereunder shall be effective unless signed by Agent and/or Lenders, as applicable in accordance with Section 12.17, and then is only effective for the specific instance and purpose for which it is given. Agent’s and Lenders’
rights and remedies under this Agreement and the other Loan Documents are cumulative. Agent and Lenders have all rights and remedies provided under the Code, at law or in equity. Agent’s or any Lender’s exercise of one right or remedy or
any partial exercise thereof is not an election and shall 

  
 20 

 
not preclude any other or further exercise of that or any other right, power or privilege, and Agent’s and Lenders’ waiver of any Event of Default is not a continuing waiver.
Agent’s and/or Lenders’ delay in exercising any remedy is not a waiver, election, or acquiescence. 
 9.7 Demand
Waiver. Borrower waives demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments,
chattel paper, and guarantees held by Agent on which Borrower is liable. 
 9.8 Borrower Liability. If more than
one (1) Borrower is party to this Agreement then the following Section 9.8 shall apply. Either Borrower may, acting singly, request Term Loans hereunder. Each Borrower hereby appoints the other as agent for the other for all purposes
hereunder, including with respect to requesting Term Loans hereunder. Each Borrower hereunder shall be jointly and severally obligated to repay all Term Loans made hereunder and all other Obligations, regardless of which Borrower actually receives
said Term Loans, as if each Borrower hereunder directly received all Term Loans. Each Borrower waives (a) any suretyship defenses available to it under the Code or any other applicable Law, and (b) any right to require the Lenders or
Agent to: (i) proceed against any Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any other remedy. The Lenders or Agent may exercise or not exercise any right or remedy they have
against any Borrower or any security (including the right to foreclose by judicial or non-judicial sale) without affecting any Borrower’s liability. Notwithstanding any other provision of this Agreement or other related document, each
Borrower irrevocably waives all rights that it may have at Law or in equity (including, without limitation, any Law subrogating Borrower to the rights of the Lenders and Agent under this Agreement) to seek contribution, indemnification or any other
form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or
otherwise and all rights that it might have to benefit from, or to participate in, any security for the Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise. Any
agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section shall be null and void. If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment
in trust for the Lenders and Agent and such payment shall be promptly delivered to Agent for application to the Obligations, whether matured or unmatured. 
  

	 	10	NOTICES 

 All
notices, consents, requests, approvals, demands, or other communication by any party to this Agreement or any other Loan Document must be in writing and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of
actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by electronic mail or facsimile
transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be addressed to the party to be notified and
sent to the addresses, facsimile numbers, or email addresses indicated below. Any of Agent, Lender or Borrower may change its mailing or electronic mail addresses or facsimile numbers by giving the other party written notice thereof in accordance
with the terms of this Section 10. 
  

			
	If to Borrower:	    	TRIA BEAUTY, INC.
		    	4160 Dublin Blvd, Suite 200
		    	Dublin, CA 94568
		    	Attn: Kevin Appelbaum
		    	Fax: (925) 452-2598
		    	Email: Kevin@TRIABeauty.com
		
	with a copy to:	    	Ropes & Gray LLP
		    	1900 University Avenue 6th Floor
		    	East Palo Alto, CA 94303
		    	Attn: David Saul
		    	Fax: (650) 566-4232
		    	Email: david.saul@ropesgray.com

  
 21 

			
	If to Agent:	    	MidCap Financial SBIC, LP
		    	7255 Woodmont Avenue, Suite 200
		    	Bethesda, Maryland 20814
		    	Attention: Portfolio Management- Life Sciences
		    	Fax: (301) 941-1450
		    	E-Mail: lviera@midcapfinancial.com
		
	with a copy to:	    	Midcap Financial, LLC
		    	7255 Woodmont Avenue, Suite 200
		    	Bethesda, Maryland 20814
		    	Attention: General Counsel
		    	Fax: (301) 941-1450
		    	E-Mail: rgoodridge@midcapfinancial.com

 If to Lenders: To the address specified on the signature page of such Lender attached hereto.

  

	 	11	CHOICE OF LAW, VENUE, JURY TRIAL WAIVER, AND JUDICIAL REFERENCE 

 California Law governs the Loan Documents without regard to principles of conflicts of Law. Borrower, Agent and each Lender each submit to the exclusive jurisdiction of the State and Federal courts in
Santa Clara County, California; provided, however, that nothing in this Agreement shall be deemed to operate to preclude Agent from bringing suit or taking other legal action in any other jurisdiction to realize on the Collateral or any other
security for the Obligations, or to enforce a judgment or other court order in favor of Agent or any of the Lenders. Borrower, Agent and each Lender each expressly submits and consents in advance to such jurisdiction in any action or suit commenced
in any such court, and Borrower, Agent and each Lender hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable
relief as is deemed appropriate by such court. Borrower, Agent and each Lender each hereby waives personal service of the summons, complaints, and other process issued in such action or suit and agrees that service of such summons, complaints, and
other process may be made by registered or certified mail at the address set forth in, or subsequently provided by accordance with, Section 10 of this Agreement and that service so made shall be deemed completed upon the earlier to occur of
actual receipt thereof or three (3) days after deposit in the U.S. mails, proper postage prepaid. 
 TO THE FULLEST
EXTENT PERMITTED BY APPLICABLE LAW, BORROWER, AGENT AND THE LENDERS EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING
CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 

WITHOUT INTENDING IN ANY WAY TO LIMIT THE PARTIES’ AGREEMENT TO WAIVE THEIR RESPECTIVE RIGHT TO A TRIAL BY JURY, if the above
waiver of the right to a trial by jury is not enforceable, the parties hereto agree that any and all disputes or controversies of any nature between them arising at any time shall be decided by a reference to a private judge, mutually selected by
the parties (or, if they cannot agree, by the Presiding Judge of the Santa Clara County, California Superior Court) appointed in accordance with California Code of Civil Procedure Section 638 (or pursuant to comparable provisions of federal Law
if the dispute falls within the exclusive jurisdiction of the federal courts), sitting without a jury, in Santa Clara County, California; and the parties hereby submit to the jurisdiction of such court. The reference proceedings shall be conducted
pursuant to and in accordance with the provisions of California Code of Civil Procedure §§ 638 through 645.1, inclusive. The private judge shall have the power, among others, to grant provisional relief, including without limitation,
entering temporary restraining orders, issuing preliminary and permanent injunctions and appointing receivers. All such proceedings shall be closed to the public and confidential and all records relating thereto shall be permanently sealed. If
during the course of any dispute, a party desires to seek provisional relief, but a judge has not 

  
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been appointed at that point pursuant to the judicial reference procedures, then such party may apply to the Santa Clara County, California Superior Court for such relief. The proceeding before
the private judge shall be conducted in the same manner as it would be before a court under the rules of evidence applicable to judicial proceedings. The parties shall be entitled to discovery which shall be conducted in the same manner as it would
be before a court under the rules of discovery applicable to judicial proceedings. The private judge shall oversee discovery and may enforce all discovery rules and orders applicable to judicial proceedings in the same manner as a trial court judge.
The parties agree that the selected or appointed private judge shall have the power to decide all issues in the action or proceeding, whether of fact or of Law, and shall report a statement of decision thereon pursuant to California Code of Civil
Procedure § 644(a). Nothing in this paragraph shall limit the right of any party at any time to exercise self-help remedies, foreclose against collateral, or obtain provisional remedies. The private judge shall also determine all issues
relating to the applicability, interpretation, and enforceability of this paragraph. 
  

	 	12	GENERAL PROVISIONS 

12.1 Successors and Assigns. 
 (a) This Agreement binds and is for the benefit of the successors and permitted assigns of each party. Borrower may not assign this Agreement or any rights or obligations under it without Agent’s
prior written consent (which may be granted or withheld in Agent’s and each Lender’s discretion). Any Lender may at any time assign to one or more Eligible Assignees all or any portion of such Lender’s Loan, together with all related
obligations of such Lender hereunder. Borrower and Agent shall be entitled to continue to deal solely and directly with such Lender in connection with the interests so assigned until Agent shall have received and accepted an effective assignment
agreement (each an “Assignment Agreement”) in form and substance reasonably acceptable to Agent, executed, delivered and fully completed by the applicable parties thereto, and shall have received such other information regarding
such Eligible Assignee as Agent reasonably shall require, which acceptance shall not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, no such assignment shall be effective until it is reflected in the register
required by Section 12.1(b) hereof. Notwithstanding anything set forth in this Agreement to the contrary, any Lender may at any time pledge or assign a security interest in all or any portion of its rights under this Agreement to secure
obligations of such Lender, including any pledge or assignment to secure obligations to a Federal Reserve Bank; provided, however, that no such pledge or assignment shall release such Lender from any of its obligations hereunder or substitute
any such pledgee or assignee for such Lender as a party hereto. 
 (b) Agent, acting solely for this purpose as an agent of
Borrower, shall maintain at its offices located in Bethesda, Maryland a copy of each Assignment Agreement delivered to it and a register for the recordation of the names and addresses of each Lender, and the commitments of, and principal amount of
the Term Loans owing to, such Lender pursuant to the terms hereof. The entries in such register shall be conclusive, and Borrower, Agent and Lenders may treat each Person whose name is recorded therein pursuant to the terms hereof as a Lender
hereunder for all purposes of this Agreement, notwithstanding notice to the contrary. Such register shall be available for inspection by Borrower and any Lender, at any reasonable time upon reasonable prior notice to Agent. 

12.2 Indemnification. 
 (a) Borrower agrees to indemnify, defend and hold Agent and the Lenders and their respective directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Agent or
the Lenders (each, an “Indemnified Person”) harmless against: (i) all obligations, demands, claims, and liabilities (collectively, “Claims”) asserted by any other party in connection with the transactions
contemplated by the Loan Documents; and (ii) all losses or expenses (including Lender Expenses) in any way suffered, incurred, or paid by Indemnified Person from, following, or arising from transactions between Agent, and/or the Lenders and
Borrower (including reasonable attorneys’ fees and expenses), except, in each case, for Claims and/or losses directly caused by such Indemnified Person’s gross negligence or willful misconduct (collectively, the “Indemnified
Liabilities”). 
 (b) Borrower hereby further indemnifies, defends and holds each Indemnified Person harmless from and
against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, claims, costs, expenses and disbursements of any kind or nature whatsoever (including the fees and disbursements of

  
 23 

 
counsel for such Indemnitee) in connection with any investigative, response, remedial, administrative or judicial matter or proceeding, whether or not such Indemnified Person shall be designated
a party thereto and including any such proceeding initiated by or on behalf of Borrower, and the reasonable expenses of investigation by engineers, environmental consultants and similar technical personnel and any commission, fee or compensation
claimed by any broker (other than any broker retained by Agent or Lenders) asserting any right to payment for the transactions contemplated hereby which may be imposed on, incurred by or asserted against such Indemnified Person as a result of or in
connection with the transactions contemplated hereby and the use or intended use of the proceeds of the loan proceeds, except, in each case, for liabilities, obligations, losses, damages, penalties, actions, judgments, suits, claims, costs, expenses
and/or disbursements directly caused by such Indemnified Person’s gross negligence or willful misconduct. 
 (c) To the
extent that the undertaking set forth in this Section 12.2 may be unenforceable, Borrower shall contribute the maximum portion which it is permitted to pay and satisfy under applicable Law to the payment and satisfaction of all such indemnified
liabilities incurred by the Indemnitees or any of them. 
 12.3 Time of Essence. Time is of the essence for the
performance of all Obligations in this Agreement. 
 12.4 Severability of Provisions. Each provision of this
Agreement is severable from every other provision in determining the enforceability of any provision. 
 12.5 Correction of
Loan Documents. Agent may correct patent errors and fill in any blanks in the Loan Documents consistent with the agreement of the parties so long as Agent provides Borrower and the Lenders with written notice of such correction and allows
Borrower and the Lenders at least ten (10) days to object to such correction. In the event of such objection, such correction shall not be made except by an amendment signed by Agent, the Lenders and Borrower. 

12.6 Integration. This Agreement and the Loan Documents represent the entire agreement about this subject matter and
supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Agreement and the Loan Documents merge into this Agreement and the
Loan Documents. 
 12.7 Counterparts. This Agreement may be executed in any number of counterparts and by
different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. 
 12.8 Survival. All covenants, representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations
(other than inchoate indemnity obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have been paid in full and satisfied. The obligation of Borrower in Section 12.2 to indemnify Agent
and the Lenders shall survive until the statute of limitations with respect to such claim or cause of action shall have run. 

12.9 Confidentiality. In handling any confidential information of Borrower, the Lenders and Agent shall exercise the same
degree of care that it exercises for its own proprietary information, but disclosure of information may be made: (a) to the Lenders’ and Agent’s Subsidiaries or Affiliates and each director, officer, employee, agent, trustee,
representative, attorney, accountant and each insurance, environmental, legal, financial and other advisor and other consultants and agents of or to such person or entity or any of its Affiliates; (b) to prospective transferees or purchasers of
any interest in the Credit Extensions (provided, however, the Lenders and Agent shall use their best efforts to obtain such prospective transferee’s or purchaser’s agreement to the terms of this provision); (c) as required by Law,
regulation, subpoena, or other order (but excluding any requirement or request made by a regulator of Agent or any Lender which is covered by clause (d) of this Section 12.9 set forth below); provided that Agent or such applicable Lender
will endeavor to give notice to Borrower in order to permit Borrower to contest such regulation, subpoena or other order; (d) to regulators or as otherwise required in connection with an examination or audit; (e) as Agent considers
appropriate in exercising remedies under the Loan Documents; and (f) to third party service providers of the Lenders and/or Agent other than the entities set forth in clause (a) so long as such service providers have executed a
confidentiality agreement with the Lenders and Agent with terms no less 

  
 24 

 
restrictive than those contained herein. In no event will confidential information include information that either: (i) is in the public domain or in the Lenders’ and/or Agent’s
possession when disclosed to the Lenders and/or Agent, or becomes part of the public domain after disclosure to the Lenders and/or Agent; or (ii) is disclosed to the Lenders and/or Agent by a third party, if the Lenders and/or Agent does not
know that the third party is prohibited from disclosing the information. Agent and/or Lenders may use confidential information for any purpose, including, without limitation, for the development of client databases, reporting purposes, and market
analysis, so long as Agent and/or Lenders, as applicable, do not disclose Borrower’s identity or the identity of any Person associated with Borrower unless otherwise expressly permitted by this Agreement. The provisions of the immediately
preceding sentence shall survive the termination of this Agreement. The agreements provided under this Section 12.9 supersede all prior agreements, understanding, representations, warranties, and negotiations between the parties about the
subject matter of this Section 12.9. 
 12.10 Intentionally Deleted. 

12.11 Electronic Execution of Documents. The words “execution,” “signed,” “signature” and
words of like import in any Loan Document shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity and enforceability as a manually executed signature or
the use of a paper-based recordkeeping systems, as the case may be, to the extent and as provided for in any applicable Law, including, without limitation, any state Law based on the Uniform Electronic Transactions Act. 

12.12 Captions. The headings used in this Agreement are for convenience only and shall not affect the interpretation of
this Agreement. 
 12.13 Construction of Agreement. The parties hereto have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise
favoring or disfavoring any party by virtue of the authorship of any provisions of this Agreement. 
 12.14
Relationship. The relationship of the parties to this Agreement is determined solely by the provisions of this Agreement. The parties do not intend to create any agency, partnership, joint venture, trust, fiduciary or other relationship
with duties or incidents different from those of parties to an arm’s-length contract. 
 12.15 Third Parties.
Nothing in this Agreement, whether express or implied, is intended to: (a) confer any benefits, rights or remedies under or by reason of this Agreement on any persons other than the express parties to it and their respective permitted
successors and assigns; (b) relieve or discharge the obligation or liability of any person not an express party to this Agreement; or (c) give any person not an express party to this Agreement any right of subrogation or action against any
party to this Agreement. 
 12.16 Right of Set Off. Borrower hereby grants to Agent and to each Lender, a lien, security
interest and right of set off as security for all Obligations to Agent and each Lender hereunder, whether now existing or hereafter arising upon and against all deposits, credits, collateral and property, now or hereafter in the possession, custody,
safekeeping or control of Agent or the Lenders or any entity under the control of Agent or the Lenders (including an Agent affiliate) or in transit to any of them. Subject to the requirements of Section 9.4, at any time after the occurrence and
during the continuance of an Event of Default, without demand or notice, Agent or the Lenders may set off the same or any part thereof and apply the same to any liability or obligation of Borrower even though unmatured and regardless of the adequacy
of any other collateral securing the Obligations. ANY AND ALL RIGHTS TO REQUIRE AGENT TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO SUCH
DEPOSITS, CREDITS OR OTHER PROPERTY OF BORROWER ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED. 
 12.17
Amendments. Unless otherwise specifically set forth in this Agreement, no amendment, modification, termination or waiver of any provision of this Agreement or any other Loan Document, no approval or consent thereunder, or any consent to
any departure by Borrower therefrom, shall in any event be effective unless the same shall be in writing and signed by Borrower, Agent and the Required Lenders, provided, however, that 

  
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 (a) no such amendment, waiver or other modification that would have the effect of
increasing or reducing a Lender’s Term Loan Commitment or Commitment Percentage shall be effective as to such Lender without such Lender’s written consent; 
 (b) no such amendment, waiver or modification that would affect the rights and duties of Agent shall be effective without Agent’s written consent or signature; 

(c) no such amendment, waiver or other modification shall, unless signed by all the Lenders directly affected thereby, (A) reduce
the principal of, rate of interest on or any fees with respect to any Term Loan or forgive any principal, interest (other than default interest) or fees (other than late charges) with respect to any Term Loan (B) postpone the date fixed for, or
waive, any payment of principal of any Term Loan or of interest on any Term Loan (other than default interest) or any fees provided for hereunder (other than late charges or for any termination of any commitment); (C) change the definition of
the term “Required Lenders” or the percentage of Lenders which shall be required for Lenders to take any action hereunder; (D) release all or substantially all or any material portion of the Collateral, authorize Borrower to sell or
otherwise dispose of all or substantially all or any material portion of the Collateral or release any Guarantor of all or any portion of the Obligations or its guaranty obligations with respect thereto, except, in each case with respect to this
clause (D), as otherwise may be expressly permitted under this Agreement or the other Loan Documents (including in connection with any disposition permitted hereunder); (E) amend, waive or otherwise modify this Section 12.17 or the
definitions of the terms used in this Section 12.17 insofar as the definitions affect the substance of this Section 12.17; (F) consent to the assignment, delegation or other transfer by any Borrower or any Guarantor of any of its
rights and obligations under any Loan Document or release Borrower or any Guarantor of its payment obligations under any Loan Document, except, in each case with respect to this clause (F), pursuant to a merger or consolidation permitted pursuant to
this Agreement; (G) amend any of the provisions of Section 9.4 or amend any of the definitions Pro Rata Share, Term Loan Commitment, Commitment Percentage or that provide for the Lenders to receive their Pro Rata Shares of any fees,
payments, setoffs or proceeds of Collateral hereunder; (H) subordinate the Liens granted in favor of Agent securing the Obligations; or (I) amend any of the provisions of Section 12.16. It is hereby understood and agreed that all
Lenders shall be deemed directly affected by an amendment, waiver or other modification of the type described in the preceding clauses (C), (D), (E), (F), (G) and (H) of the preceding sentence; and 

(d) the provisions of the foregoing clauses (i), (ii) and (iii) are subject to the provisions of any interlender or agency
agreement among the Agent and Lenders pursuant to which any Lender may agree to give its consent in connection with any amendment, waiver or modification of the Loan Documents only in the event of the unanimous agreement of all Lenders. 

12.18 Publicity. Borrower will not directly or indirectly publish, disclose or otherwise use in any public disclosure,
advertising material, promotional material, press release or interview, any reference to the name, logo or any trademark of Agent or any Lender or any of their Affiliates or any reference to this Agreement or the financing evidenced hereby, in any
case except as required by applicable Law, subpoena or judicial or similar order, in which case Borrower shall endeavor to give Agent prior written notice of such publication or other disclosure. Each Lender and Borrower hereby authorizes each
Lender to publish the name of such Lender and Borrower, the existence of the financing arrangements referenced under this Agreement, the primary purpose and/or structure of those arrangements, the amount of credit extended under each facility, the
title and role of each party to this Agreement, and the total amount of the financing evidenced hereby in any “tombstone”, comparable advertisement or press release which such Lender elects to submit for publication. In addition, each
Lender and Borrower agrees that each Lender may provide lending industry trade organizations with information necessary and customary for inclusion in league table measurements after the Effective Date. With respect to any of the foregoing, such
authorization shall be subject to such Lender providing Borrower and the other Lenders with an opportunity to review and confer with such Lender regarding, and approve, the contents of any such tombstone, advertisement or information, as applicable,
prior to its initial submission for publication, but subsequent publications of the same tombstone, advertisement or information shall not require Borrower’s approval. 

 

	 	13	AGENT 

 13.1
Appointment and Authorization of Agent. Each Lender hereby irrevocably appoints, designates and authorizes Agent to take such action on its behalf under the provisions of this Agreement and each other Loan

  
 26 

 
Document and to exercise such powers and perform such duties as are expressly delegated to it by the terms of this Agreement or any other Loan Document, together with such powers as are
reasonably incidental thereto. Notwithstanding any provision to the contrary contained elsewhere herein or in any other Loan Document, Agent shall not have any duties or responsibilities, except those expressly set forth herein, nor shall Agent have
or be deemed to have any fiduciary relationship with any Lender or participant, and no implied covenants, functions, responsibilities, duties, obligations or liabilities shall be read into this Agreement or any other Loan Document or otherwise exist
against Agent. Without limiting the generality of the foregoing sentence, the use of the term “agent” herein and in the other Loan Documents with reference to Agent is not intended to connote any fiduciary or other implied (or express)
obligations arising under agency doctrine of any applicable Law. Instead, such term is used merely as a matter of market custom, and is intended to create or reflect only an administrative relationship between independent contracting parties.

 13.2 Delegation of Duties. Agent may execute any of its duties under this Agreement or any other Loan Document
by or through its, or its Affiliates’, agents, employees or attorneys-in-fact and shall be entitled to obtain and rely upon the advice of counsel and other consultants or experts concerning all matters pertaining to such duties. Agent shall not
be responsible for the negligence or misconduct of any agent or attorney-in-fact that it selects in the absence of gross negligence or willful misconduct. 
 13.3 Liability of Agent. Except as otherwise provided herein, no Agent-Related Person shall (a) be liable for any action taken or omitted to be taken by any of them under or in
connection with this Agreement or any other Loan Document or the transactions contemplated hereby (except for its own gross negligence or willful misconduct in connection with its duties expressly set forth herein), or (b) be responsible in any
manner to any Lender or participant for any recital, statement, representation or warranty made by Borrower or any officer thereof, contained herein or in any other Loan Document, or in any certificate, report, statement or other document referred
to or provided for in, or received by Agent under or in connection with, this Agreement or any other Loan Document, or the validity, effectiveness, genuineness, enforceability or sufficiency of this Agreement or any other Loan Document, or for any
failure of Borrower or any other party to any Loan Document to perform its obligations hereunder or thereunder. No Agent-Related Person shall be under any obligation to any Lender or participant to ascertain or to inquire as to the observance or
performance of any of the agreements contained in, or conditions of, this Agreement or any other Loan Document, or to inspect the properties, Borrower’s Books or any Affiliate thereof. 

13.4 Reliance by Agent. Agent shall be entitled to rely, and shall be fully protected in relying, upon any writing,
communication, signature, resolution, representation, notice, consent, certificate, affidavit, letter, telegram, facsimile, telex or telephone message, electronic mail message, statement or other document or conversation believed by it to be genuine
and correct and to have been signed, sent or made by the proper Person or Persons, and upon advice and statements of legal counsel (including counsel to Borrower), independent accountants and other experts selected by Agent. Agent shall be fully
justified in failing or refusing to take any action under any Loan Document unless it shall first receive such advice or concurrence of all Lenders as it deems appropriate and, if it so requests, it shall first be indemnified to its satisfaction by
the Lenders against any and all liability and expense which may be incurred by it by reason of taking or continuing to take any such action. Agent shall in all cases be fully protected in acting, or in refraining from acting, under this Agreement or
any other Loan Document in accordance with a request or consent of all Lenders and such request and any action taken or failure to act pursuant thereto shall be binding upon all the Lenders. 

13.5 Notice of Default. Agent shall not be deemed to have knowledge or notice of the occurrence of any Default and/or Event
of Default, unless Agent shall have received written notice from a Lender or Borrower, expressly stating that such Event of Default exists and describing such default or Event of Default. Agent will promptly notify the Lenders of its receipt of any
such notice. Agent shall take such action with respect to an Event of Default as may be directed in writing by the Required Lenders in accordance with Section 9.1; provided, however, that while an Event of Default has occurred and is
continuing, Agent may (but shall not be obligated to) take such action, or refrain from taking such action, with respect to such Event of Default as Agent shall deem advisable or in the best interest of the Lenders, including without limitation,
satisfaction of other security interests, liens or encumbrances on the Collateral not permitted under the Loan Documents, payment of taxes on behalf of Borrower, and other actions to protect and safeguard the Collateral, and actions with respect to
insurance claims for casualty events affecting Borrower and/or the Collateral and payments to landlords, warehouseman, bailees and other Persons in possession of the Collateral, payments to Governmental Authorities to maintain, continue, preserve

  
 27 

 
and protect the Intellectual Property of Borrower and its Subsidiaries and/or the rights and remedies of Borrower and its Subsidiaries with respect thereto. All costs and expenses (including
reasonable attorneys’ fees and expenses) incurred by Agent in taking actions described in this Section 13.5 (including any and all such amounts so paid by Agent) are Lender Expenses owing to Agent and immediately due and payable by the
Borrower, bearing interest at the then highest rate applicable to the Obligations, and secured by the Collateral. 
 13.6
Credit Decision; Disclosure of Information by Agent. Each Lender acknowledges that no Agent-Related Person has made any representation or warranty to it, and that no act by Agent hereafter taken, including any consent to and acceptance of
any assignment or review of the affairs of Borrower or any Affiliate thereof, shall be deemed to constitute any representation or warranty by any Agent-Related Person to any Lender as to any matter, including whether Agent-Related Persons have
disclosed material information in their possession. Each Lender represents to Agent that it has, independently and without reliance upon any Agent-Related Person and based on such documents and information as it has deemed appropriate, made its own
appraisal of, and investigation into, the business, prospects, operations, property, financial and other condition and creditworthiness of Borrower and its respective Subsidiaries, and all applicable bank or other regulatory Laws relating to the
transactions contemplated hereby, and made its own decision to enter into this Agreement and to extend credit to Borrower hereunder. Each Lender also represents that it will, independently and without reliance upon any Agent-Related Person and based
on such documents and information as it shall deem appropriate at the time, continue to make its own credit analysis, appraisals and decisions in taking or not taking action under this Agreement and the other Loan Documents, and to make such
investigations as it deems necessary to inform itself as to the business, prospects, operations, property, financial and other condition and creditworthiness of Borrower. Except for notices, reports and other documents expressly required to be
furnished to the Lenders by Agent herein, Agent shall not have any duty or responsibility to provide any Lender with any credit or other information concerning the business, prospects, operations, property, financial and other condition or
creditworthiness of Borrower or any of its Affiliates which may come into the possession of any Agent-Related Person. 
 13.7
Indemnification of Agent. Whether or not the transactions contemplated hereby are consummated, each Lender shall, severally and pro rata based on its respective Pro Rata Share, indemnify, within thirty (30) days after written demand,
each Agent-Related Person (to the extent not reimbursed by or on behalf of Borrower and without limiting the obligation of Borrower to do so), and hold harmless each Agent-Related Person from and against any and all Indemnified Liabilities (which
shall not include legal expenses of Agent incurred in connection with the closing of the transactions contemplated by this Agreement) incurred by it; provided, however, that no Lender shall be liable for the payment to any Agent-Related
Person of any portion of such Indemnified Liabilities to the extent determined in a final judgment by a court of competent jurisdiction to have resulted from such Agent-Related Person’s own gross negligence or willful misconduct; provided,
however, that no action taken in accordance with the directions of the Required Lenders shall be deemed to constitute gross negligence or willful misconduct for purposes of this Section 13.7. Without limitation of the foregoing, each Lender
shall, severally and pro rata based on its respective Pro Rata Share, reimburse Agent, within thirty (30) days after written demand for its ratable share of any costs or out-of-pocket expenses (including Lender Expenses incurred after the
closing of the transactions contemplated by this Agreement) incurred by Agent (in its capacity as Agent, and not as a Lender) in connection with the preparation, execution, delivery, administration, modification, amendment or enforcement (whether
through negotiations, legal proceedings or otherwise) of, or legal advice in respect of rights or responsibilities under, this Agreement, any other Loan Document, or any document contemplated by or referred to herein, to the extent that Agent is not
reimbursed for such expenses by or on behalf of Borrower. The undertaking in this Section 13.7 shall survive the payment in full of the Obligations, the termination of this Agreement and the resignation of Agent. 

13.8 Agent in its Individual Capacity. With respect to its Credit Extensions, MidCap shall have the same rights and powers
under this Agreement as any other Lender and may exercise such rights and powers as though it were not Agent, and the terms “Lender” and “Lenders” include MidCap in its individual capacity. 

13.9 Successor Agent. 
 (a) Agent may at any time assign its rights, powers, privileges and duties hereunder to (i) another Lender, or (ii) any Person to whom Agent, in its capacity as a Lender, has assigned (or will
assign, in conjunction with such assignment of agency rights hereunder) 50% or more of its Loan, in each case without the 

  
 28 

 
consent of the Lenders or Borrowers. Following any such assignment, Agent shall give notice to the Lenders and Borrowers. An assignment by Agent pursuant to this subsection (a) shall not be
deemed a resignation by Agent for purposes of subsection (b) below. 
 (b) Without limiting the rights of Agent to
designate an assignee pursuant to subsection (a) above, Agent may at any time give notice of its resignation to the Lenders and Borrowers. Upon receipt of any such notice of resignation, Required Lenders shall have the right to appoint a
successor Agent. If no such successor shall have been so appointed by Required Lenders and shall have accepted such appointment within thirty (30) days after the retiring Agent gives notice of its resignation, then the retiring Agent may, on
behalf of the Lenders, appoint a successor Agent; provided, however, that if Agent shall notify Borrowers and the Lenders that no Person has accepted such appointment, then such resignation shall nonetheless become effective in accordance
with such notice from Agent that no Person has accepted such appointment and, from and following delivery of such notice, (i) the retiring Agent shall be discharged from its duties and obligations hereunder and under the other Loan Documents,
and (ii) all payments, communications and determinations provided to be made by, to or through Agent shall instead be made by or to each Lender directly, until such time as Required Lenders appoint a successor Agent as provided for above in
this subsection (b). 
 (c) Upon (i) an assignment permitted by subsection (a) above, or (ii) the acceptance of a
successor’s appointment as Agent pursuant to subsection (b) above, such successor shall succeed to and become vested with all of the rights, powers, privileges and duties of , and all the Liens in the Collateral securing the Obligations
granted pursuant to this Agreement and the other Loan Documents to and/or held by, the assigning or retiring (or retired) Agent, and the assigning or retiring Agent shall be discharged from all of its duties and obligations hereunder and under the
other Loan Documents (if not already discharged therefrom as provided above in this subsection (c)). The fees payable by Borrowers to an assignee or successor Agent shall be the same as those payable to its predecessor unless otherwise agreed
between Borrower and such successor. After the assigning or retiring Agent’s resignation hereunder and under the other Loan Documents, the provisions of this Section 13 shall continue in effect for the benefit of such assigning or
retiring Agent and its sub-agents in respect of any actions taken or omitted to be taken by any of them while the assigning or retiring Agent was acting 
 13.10 Agent May File Proofs of Claim. In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial
proceeding relative to Borrower, Agent (irrespective of whether the principal of any Loan, shall then be due and payable as herein expressed or by declaration or otherwise and irrespective of whether Agent shall have made any demand on Borrower)
shall be entitled and empowered, by intervention in such proceeding or otherwise: 
 (a) to file and prove a claim for the whole
amount of the principal and interest owing and unpaid in respect of the Credit Extensions and all other Obligations that are owing and unpaid and to file such other documents as may be necessary or advisable in order to have the claims of the
Lenders and Agent (including any claim for the reasonable compensation, expenses, disbursements and advances of the Lenders and Agent and their respective agents and counsel and all other amounts due the Lenders and Agent allowed in such judicial
proceeding); and 
 (b) to collect and receive any monies or other property payable or deliverable on any such claims and to
distribute the same; 
 and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in any such judicial
proceeding is hereby authorized by each Lender to make such payments to Agent for itself and the benefit of the Lenders and, in the event that Agent shall consent to the making of such payments directly to the Lenders, to pay to Agent any amount due
for the reasonable compensation, expenses, disbursements and advances of Agent and its agents and counsel, and any other amounts due Agent under Section 2.4(c). To the extent that Agent fails timely to do so, each Lender may file a claim
relating to such Lender’s claim. 
 13.11 Collateral and Guaranty Matters. The Lenders irrevocably authorize
Agent, at its option and in its discretion, to release any Guarantor and any Lien on any Collateral granted to or held by Agent under any Loan Document (a) upon the date that all Obligations due hereunder have been fully and indefeasibly paid
in full and no 

  
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Term Loan Commitments or other obligations of any Lender to provide funds to Borrower under this Agreement remain outstanding, (b) that is transferred or to be transferred as part of or in
connection with any Transfer permitted hereunder or under any other Loan Document, or (c) as approved in accordance with Section 12.17. Upon request by Agent at any time, all Lenders will confirm in writing Agent’s authority to
release its interest in particular types or items of Property, pursuant to this Section 13.11. 
 13.12 Cooperation of
Borrower. If necessary, Borrower agrees to (a) execute any documents (including new Secured Promissory Notes) reasonably required to effectuate and acknowledge each assignment of a Term Loan Commitment or Loan to an assignee in
accordance with Section 12.1, (b) upon Agent’s reasonable request, make Borrower’s management available, at reasonable times and upon reasonable notice, to meet with Agent and prospective participants and assignees of Term Loan
Commitments or Credit Extensions and (c) assist Agent or the Lenders in the preparation of information relating to the financial affairs of Borrower as any prospective participant or assignee of a Term Loan Commitment or Term Loan reasonably
may request. Subject to the provisions of Section 12.9 Borrower authorizes each Lender to disclose to any prospective participant or assignee of a Term Loan Commitment, any and all information in such Lender’s possession concerning
Borrower and its financial affairs which has been delivered to such Lender by or on behalf of Borrower pursuant to this Agreement, or which has been delivered to such Lender by or on behalf of Borrower in connection with such Lender’s credit
evaluation of Borrower prior to entering into this Agreement. 
 13.13 Once Again Me Letter of Credit Collateral
Account. Notwithstanding anything to the contrary contained in that certain Bank Services Pledge Agreement (Cash-Secured) dated as of December 15, 2011, by Borrower in favor of SVB, SVB hereby consents to the security interest
granted by Borrower to Agent, for the ratable benefit of the Lenders, in the Once Again Me Letter of Credit Collateral Account pursuant to the terms of this Agreement. 
  

	 	14	DEFINITIONS 

14.1 Definitions. As used in the Loan Documents, the word “shall” is mandatory, the word “may” is
permissive, the word “or” is not exclusive, the words “includes” and “including” are not limiting, the singular includes the plural, and numbers denoting amounts that are set off in brackets are negative. As used in
this Agreement, the following capitalized terms have the following meanings: 
 “Access Agreement” means a
landlord consent, bailee letter or warehouseman’s letter, in form and substance reasonably satisfactory to Agent, in favor of Agent executed by such landlord, bailee or warehouseman, as applicable, for any third party location required pursuant
to Section 7.2. 
 “Account” is any “account” as defined in the Code with such additions to such
term as may hereafter be made, and includes, without limitation, all accounts receivable and other sums owing to Borrower. 

“Account Debtor” is any “account debtor” as defined in the Code with such additions to such term
as may hereafter be made. 
 “Affiliate” is, with respect to any Person, each other Person that owns or
controls directly or indirectly the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited
liability company, that Person’s managers and members. 
 “Agent” means, MidCap, not in its individual
capacity, but solely in its capacity as agent on behalf of and for the benefit of the Lenders. 
 “Agent-Related
Person” means the Agent, together with its Affiliates, and the officers, directors, employees, agents, advisors, auditors and attorneys-in-fact of such Persons; provided, however, that no Agent-Related Person shall be an Affiliate of
Borrower. 
 “Agreement” is defined in the preamble hereof. 

  
 30 

 “Amortization Date” means January 1, 2013. 

“Anti-Terrorism Laws” means any Laws relating to terrorism or money laundering, including Executive Order No. 13224
(effective September 24, 2001), the USA PATRIOT Act, the Laws comprising or implementing the Bank Secrecy Act, and the Laws administered by OFAC. 
 “Approved Fund” means any (a) investment company, fund, trust, securitization vehicle or conduit that is (or will be) engaged in making, purchasing, holding or otherwise investing in
commercial loans and similar extensions of credit in the Ordinary Course of Business, or (b) any Person (other than a natural person) which temporarily warehouses loans for any Lender or any entity described in the preceding clause (a) and
that, with respect to each of the preceding clauses (a) and (b), is administered or managed by (i) a Lender, (ii) an Affiliate of a Lender or (iii) a Person (other than a natural person) or an Affiliate of a Person (other than a
natural person) that administers or manages a Lender. 
 “Approved Goods and Services” means goods sold and/or
services rendered by Borrower in the Ordinary Course of Business, in material compliance with all Laws. 
 “Assignment
Agreement” is defined in Section 12.1. 
 “Basic Rate” means with respect to a Term Loan,
the per annum rate of interest (based on a year of 360 days) equal to the greater of (i) nine and thirty six one hundredths percent (9.36%) and (ii) the sum of (a) U.S. Treasury note yield to maturity for a term equal to the
Treasury Note Maturity as reported in the Federal Reserve Statistical Release H.15-Selected Interest Rates under the heading “U.S. Government Securities/Treasury Constant Maturities” three (3) Business Days prior to the Funding Date
of such Term Loan, plus (b) eight and ninety-five one hundredths percent (8.95%). (In the event Release H.15 is no longer published, Agent shall select a comparable publication to determine the U.S. Treasury note yield to maturity.)

 “Blocked Person” means: (a) any Person listed in the annex to, or is otherwise subject to
the provisions of, Executive Order No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224,
(c) a Person with which any Lender is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports “terrorism” as defined in
Executive Order No. 13224, or (e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list. 

“Borrower” is defined in the preamble hereof. 
 “Borrower’s Books” are all Borrower’s books and records including ledgers, federal and state tax returns, records regarding Borrower’s assets or liabilities, the
Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 
 “Business Day” is any day that is not a Saturday, Sunday or a day on which Agent is closed. 
 “Cash Equivalents” means (a) marketable direct obligations issued or unconditionally guaranteed by the United States or any agency or any State thereof having maturities of not more
than one (1) year from the date of acquisition, (b) commercial paper maturing no more than one (1) year after its creation and having the highest rating from either Standard & Poor’s Ratings Group or Moody’s
Investors Service, Inc. and (c) certificates of deposit issued maturing no more than one (1) year after issue provided that the account in which any such certificate of deposit is maintained is subject to a Control Agreement in favor of
Agent. For the avoidance of doubt, the direct purchase by Borrower, co-borrower, or any subsidiary of Borrower of any auction rate securities, or purchasing participations in, or entering into any type of swap or other derivative transaction, or
otherwise holding or engaging in any ownership interest in any type of auction rate security by Borrower, co-borrower, or any subsidiary of Borrower shall be conclusively determined by the Lenders as an ineligible Cash Equivalent, and any such
transaction shall expressly violate each other provision of this Agreement governing Permitted Investments. Notwithstanding the foregoing, Cash Equivalents does not include and Borrower and its Subsidiaries are prohibited

  
 31 

 
from purchasing, purchasing participations in, entering into any type of swap or other equivalent derivative transaction, or otherwise holding or engaging in any ownership interest in any type of
debt instrument, including, without limitation, any corporate or municipal bonds with a long-term nominal maturity for which the interest rate is reset through a dutch auction and more commonly referred to as an auction rate security. 

“Change in Control” means any event, transaction, or occurrence as a result of which (a) the
stockholders of Borrower as of the Effective Date cease to own and control all of the economic and voting rights associated with ownership of at least sixty percent (60%) of the outstanding securities of all classes of the Borrower on a fully
diluted basis; (b) any “person” (as such term is defined in Sections 3(a)(9) and 13(d)(3) of the Exchange Act), other than a trustee or other fiduciary holding securities under an employee benefit plan of Borrower, is or becomes a
beneficial owner (within the meaning Rule 13d-3 promulgated under the Exchange Act), directly or indirectly, of securities of Borrower, representing twenty-five percent (25%) or more of the combined voting power of Borrower’s then
outstanding securities; (c) during any period of twelve consecutive calendar months, individuals who at the beginning of such period constituted the Board of Directors of Borrower (together with any new directors whose election by the Board of
Directors of Borrower was approved by a vote of not less than two-thirds of the directors then still in office who either were directions at the beginning of such period or whose election or nomination for election was previously so approved) cease
for any reason other than death or disability to constitute a majority of the directors then in office; (d) Borrower ceases to own and control, directly or indirectly, all of the economic and voting rights associated with the outstanding
securities of each of its Subsidiaries, other than, solely with respect to Foreign Subsidiaries, a director’s qualifying shares and shares issued to foreign nationals to the extent required by applicable Law; or, (e) the occurrence of any
“change of control” or any term of similar effect under any Subordinated Debt document; provided, that, in the cases of clauses (a), (b) and (c) above, to the extent that such event, transaction or occurrence outlined in clauses
(a), (b) and (c), respectively, arise as a direct result of the sale of Borrower’s equity securities in an initial public offering, such event, transaction or occurrence shall not result in Change of Control. 

“Code” is the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of
California; provided, that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article
or Division 9 shall govern; provided further, that in the event that, by reason of mandatory provisions of Law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Agent’s Lien on any Collateral is governed by
the Uniform Commercial Code in effect in a jurisdiction other than the State of California, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes of the
provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions. 
 “Collateral” is any and all properties, rights and assets of Borrower described on Exhibit A. 
 “Collateral Account” is any Deposit Account, Securities Account, or Commodity Account. 
 “Commitment Percentage” means, as to any Lender, the percentage set forth opposite such Lender’s name on Schedule 1, as amended from time to time. 

“Commodity Account” is any “commodity account” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Compliance Certificate” means a certificate, duly executed by an authorized officer of
Borrower, appropriately completed and substantially in the form of Exhibit C. 
 “Contingent Obligation”
is, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation, in each case, directly or indirectly
guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all
obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or
commodity prices; but “Contingent Obligation” does not 

  
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include endorsements in the Ordinary Course of Business. The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is
made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 

“Control Agreement” means any control agreement entered into among the depository institution at which Borrower
maintains a Deposit Account or the securities intermediary or commodity intermediary at which Borrower maintains a Securities Account or a Commodity Account, Borrower, and Agent pursuant to which Agent obtains control (within the meaning of the
Code) for the benefit of the Lenders over such Deposit Account, Securities Account or Commodity Account. 

“Copyrights” are any and all copyright rights, copyright applications, copyright registrations and like protections in
each work or authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret. 
 “Core Intellectual Property” means Intellectual Property whether owned or licensed material to Borrower’s and its Subsidiaries’ business, as determined by Agent and the Required
Lenders in their reasonable credit judgment. 
 “Credit Extension” means any Term Loan or any other extension
of credit by Agent or the Lenders for Borrower’s benefit under and pursuant to this Agreement. 
 “Credit Party
Subsidiary” is any Subsidiary of Borrower that either (i) becomes a co-borrower hereunder or (ii) guarantees the obligations of the Borrower under this Agreement in accordance with Section 6.11 hereof. 

“DEA” means the Drug Enforcement Administration of the United States of America, and any successor agency thereof.

 “Default” means any event which with notice or passage of time or both, would constitute an Event of
Default. 
 “Default Rate” is defined in Section 2.3(b). 

“Deposit Account” is any “deposit account” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Designated Deposit Account” means Borrower’s Deposit Account, account number
3300760853, maintained with SVB and over which Agent has been granted control for the ratable benefit of all Lenders. 

“Dollars,” “dollars” or use of the sign “$” means only lawful money of the
United States and not any other currency, regardless of whether that currency uses the “$” sign to denote its currency or may be readily converted into lawful money of the United States. 

“Dollar Equivalent” is, at any time, (a) with respect to any amount denominated in Dollars, such amount, and
(b) with respect to any amount denominated in a Foreign Currency, the equivalent amount therefor in Dollars as determined by Agent at such time on the basis of the then-prevailing rate of exchange in San Francisco, California, for sales of the
Foreign Currency for transfer to the country issuing such Foreign Currency. 
 “Draw Period” is the period of
time from the date Borrower provides evidence satisfactory to Agent in its reasonable discretion that Borrower has successfully launched FAN either (i) in the United States or (ii) in both Canada and Europe and, in either case, continuing
through the earliest to occur of (a) the Draw Period Termination Date and (b) an Event of Default. 
 “Draw
Period Termination Date” means December 31, 2012. 

  
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 “Effective Date” is defined in the preamble hereof. 

“Effective Date Warrants” are those certain Warrants to Purchase Stock dated as of the Effective Date executed by
Borrower in favor of each applicable Lender. 
 “Eligible Assignee” means (a) a Lender, (b) an
Affiliate of a Lender, (c) an Approved Fund, (d) any commercial bank, savings and loan association or savings bank or any other entity which is an “accredited investor” (as defined in Regulation D under the Securities Act) which
extends credit or buys loans as one of its businesses, including insurance companies, mutual funds, lease financing companies, small business investment companies and commercial finance companies, in each case, which has a rating of BBB or higher
from Standard & Poor’s Financial Services LLC or together with its affiliated entities holds loan assets of $750,000,000 or more and (e) any other Person (other than a natural person) approved by Agent; provided, however,
that notwithstanding the foregoing, “Eligible Assignee” shall not include (x) Borrower, any Guarantor or any of Borrower’s or any Guarantor’s Affiliates or Subsidiaries, (y) any Person who is not capable of lending to
Borrower without the imposition of any withholding or similar taxes and (z) any Person that holds any subordinated debt or stock issued by Borrower, any Guarantor or any of Borrower’s or any Guarantor’s Affiliates or Subsidiaries on
the date that such Person becomes a Lender (other than any Lender or any Affiliate of any Lender in connection with the Warrants issued hereunder). Notwithstanding the foregoing, in connection with assignments by a Lender due to a forced divestiture
at the request of any regulatory agency, the restrictions set forth herein shall not apply and Eligible Assignee shall mean any Person or party becoming an assignee incident to such forced divestiture. 

“Equipment” is all “equipment” as defined in the Code with such additions to such term as may hereafter be
made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 
 “ERISA” means the Employee Retirement Income Security Act of 1974, and all regulations promulgated thereunder. 
 “Event of Default” is defined in Section 8. 

“Exchange Act” is the Securities Exchange Act of 1934, as amended. 

“Excluded Accounts” means (i) Deposit Accounts exclusively used for payroll, payroll taxes and other employee wage
and benefit payments to or for the benefit of Borrower’s or a Subsidiary’s employees and identified to Agent by Borrower as such, (ii) the Once Again Me Letter of Credit Collateral Account and (iii) any other Deposit Accounts of
Borrower held outside the United States as to which Agent and the Lenders may consent in writing in its sole discretion. 

“Existing SVB Indebtedness” means the Indebtedness in the original principal amount of $10,000,000 owed by Borrower to
SVB pursuant to the Amended and Restated Loan and Security Agreement, dated August 9, 2011, by and among Borrower and SVB as amended 
 “FAN” means the skin rejuvenation laser product under development as of the date hereof. 
 “FDA” means the Food and Drug Administration of the United States of America, or any successor entity thereto. 
 “Final Payment” means a payment (in addition to and not a substitution for the regular monthly payments of principal plus accrued interest) owing to each Lender, with respect to each Term
Loan made by such Lender, due on the earlier to occur of (a) the Maturity Date, (b) the acceleration of any Term Loan, and (c) the prepayment of an entire Term Loan pursuant to Section 2.1.1(c) or 2.1.1(d), equal to the original
principal amount of such Term Loan less the aggregate amount of partial prepayments of such Term Loan made pursuant to Section 2.1.1(d) multiplied by the Final Payment Percentage. 

“Final Payment Percentage” is five percent (5.00%). 

  
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 “Foreign Currency” means lawful money of a country other than the United
States. 
 “Foreign Share Pledge Documents” means with respect to any Foreign Subsidiary, a share pledge
agreement under the Laws of such foreign country or the appropriate local jurisdiction within such foreign country as determined by such local counsel, minutes of board of directors and related documents, request to update the shareholders registry,
updated shareholders registry, seal certificate and any other documents reasonably requested by Agent with respect to the pledge by Borrower to Agent of sixty-six percent (66%) of the issued and outstanding equity securities of such Foreign
Subsidiary as required under Section 6.11 of this Agreement, as applicable and in each applicable case, pursuant to the Laws of the jurisdiction of such Foreign Subsidiary’s formation. 

“Foreign Subsidiary” means a Subsidiary that is organized under the Laws of a jurisdiction other than the United
States or any state thereof or the District of Columbia. 
 “Funding Date” is any date on which a Credit
Extension is made to or for the account of Borrower which shall be a Business Day. 
 “GAAP” is
generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting
Standards Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination. 

“General Intangibles” is all “general intangibles” as defined in the Code in effect on the date hereof with
such additions to such term as may hereafter be made, and includes without limitation, all Intellectual Property, claims, income and other tax refunds, security and other deposits, payment intangibles, contract rights, options to purchase or sell
real or personal property, rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of
insurance and rights to payment of any kind. 
 “Governmental Approval” is any consent, authorization,
approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority. 

“Governmental Authority” is any nation or government, any state or other political subdivision thereof, any agency,
authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities exchange and any
self-regulatory organization. 
 “Immaterial Subsidiaries” means, collectively, (i) one or more Foreign
Subsidiaries of Borrower whose total annual revenues, determined as of the delivery from Borrower to Agent of its monthly financial statements pursuant to Section 6.2(a)(i) hereof, in the aggregate for all such Foreign Subsidiaries account for
less than ten percent (10%) of the total annual revenues of Borrower and its Subsidiaries on a consolidated basis and (ii) Once Again Me. 
 “Indebtedness” is (a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of
credit, but excluding accounts payable in the Ordinary Course of Business not past due 120 days or more, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and (d) Contingent
Obligations. 
 “Indemnified Person” is defined in Section 12.2. 

“Insolvency Proceeding” is any proceeding by or against any Person under the United States Bankruptcy Code, or any other
bankruptcy or insolvency Law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 

  
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 “Intellectual Property” means all of Borrower’s right, title, and
interest in and to the following: 
 (a) its Copyrights, Trademarks and Patents; 

(b) any and all trade secrets and trade secret rights, including, without limitation, any rights to unpatented inventions, know-how,
operating manuals; 
 (c) any and all source code; 
 (d) any and all design rights which may be available to a Borrower; 
 (e) any and
all claims for damages by way of past, present and future infringement of any of the foregoing, with the right, but not the obligation, to sue for and collect such damages for said use or infringement of the Intellectual Property rights identified
above; and 
 (f) all amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents. 

“Inventory” is all “inventory” as defined in the Code in effect on the date hereof with such additions to such
term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including without limitation such inventory as is temporarily out
of Borrower’s custody or possession or in transit and including any returned goods and any documents of title representing any of the above. 
 “Investment” is any beneficial ownership interest in any Person (including stock, partnership interest or other securities), and any loan, advance or capital contribution to any Person.

 “Japanese Share Pledge Documents” is a share pledge agreement under the Laws of Japan or the appropriate
local jurisdiction within Japan as determined by local Japanese counsel, minutes of board of directors and related documents, request to update the shareholders registry, updated shareholders registry, seal certificate and any other documents
reasonably requested by Agent with respect to the pledge by Borrower to Agent of the issued and outstanding Shares of Tria Japan pursuant to the Laws of the jurisdiction of Tria Japan’s formation. 

“Key Person” means Borrower’s Chief Executive Officer, who is Kevin J. Appelbaum as of the Effective Date.

 “Korean Share Pledge Documents” is a share pledge agreement under the Laws of South Korea or the appropriate
local jurisdiction within South Korea as determined by local South Korean counsel, minutes of board of directors and related documents, request to update the shareholders registry, updated shareholders registry, seal certificate and any other
documents reasonably requested by Agent with respect to the pledge by Borrower to Agent of the issued and outstanding Shares of Tria Korea pursuant to the Laws of the jurisdiction of Tria Korea’s formation. 

“Laws” means any and all federal, state, provincial, territorial, local and foreign statutes, laws, judicial decisions,
regulations, guidances, guidelines, ordinances, rules, judgments, orders, decrees, codes, plans, injunctions, permits, concessions, grants, franchises, governmental agreements and governmental restrictions, whether now or hereafter in effect, which
are applicable to any Borrower in any particular circumstance. 
 “Lender” means any one of the Lenders.

 “Lenders” means the Persons identified on Schedule 1 hereto, and each assignee that becomes a party
to this Agreement pursuant to Section 12.1(a). 
 “Lender Expenses” means all audit fees and expenses,
costs, and expenses (including reasonable external attorneys’ fees and out-of-pocket expenses) of Agent and Lenders for preparing, amending, negotiating, 

  
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administering, defending, enforcing, exercising remedies with respect to and making protective advances with respect to any of the Loan Documents (including, without limitation, those incurred in
connection with appeals or Insolvency Proceedings) or otherwise incurred by Agent or the Lenders in connection with the Loan Documents. 
 “Lien” is a claim, mortgage, deed of trust, levy, charge, pledge, security interest or other encumbrance of any kind, whether voluntarily incurred or arising by operation of Law or
otherwise against any property. 
 “Loan Documents” are, collectively, this Agreement, the Warrants, the
Perfection Certificate, the Japanese Share Pledge Documents, the U.K. Share Pledge Documents, the Korean Share Pledge Documents, any other Foreign Share Pledge Documents, the SBIC Letter Agreement, any note, or notes, including, without limitation,
the Secured Promissory Notes, guaranties, security agreements or other collateral documents executed by Borrower, any Guarantor or any Credit Party Subsidiary, and each other agreement, instrument, certificate, report and other document executed and
delivered by Borrower, any Guarantor or any Credit Party Subsidiary in favor of Agent or any Lender in connection with this Agreement, together with all landlord waivers, licensor consent or waiver, subordination and intercreditor agreements or
similar agreements executed and delivered by a third party in favor of Agent or any Lender in connection with this Agreement, the Credit Extensions and/or any security therefore, all as amended, restated, or otherwise modified. 

“Major Investors” are those certain venture capital investors in Borrower entitled to enhanced disclosure from Borrower
pursuant to the Borrower’s Amended and Restated Stockholders Agreement, as such agreement may be amended from time to time. 
 “Material Adverse Change” means (a) a material impairment in the perfection or priority of the Agent’s Lien in the Collateral or in the value of such Collateral; (b) a
material adverse change in the business, operations, or condition (financial or otherwise) of Borrower; or (c) a material impairment of the prospect of repayment of any portion of the Obligations. 

“Material Subsidiary” means any Subsidiary of Borrower other than an Immaterial Subsidiary. 

“Maturity Date” means July 1, 2015 for each Term Loan. 

“Net Sales” means the net sales of Borrower and its Subsidiaries on a consolidated basis in the Ordinary Course of
Business and in accordance with GAAP. 
 “Obligations” means all of Borrower’s obligations to pay when due
any debts, principal, interest, Lender Expenses, the Prepayment Fee, the Final Payment, and other amounts Borrower owes the Lenders now or later, under this Agreement or the other Loan Documents to which Borrower is a party, including, without
limitation, interest accruing after Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of Borrower assigned to the Lenders and/or Agent, and the performance of Borrower’s duties under the Loan Documents
to which it is a party (other than the Warrants). 
 “OFAC” means the U.S. Department of Treasury Office of
Foreign Assets Control. 
 “OFAC Lists” means, collectively, the Specially Designated Nationals and Blocked
Persons List maintained by OFAC pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and regulations of OFAC or
pursuant to any other applicable Executive Orders. 
 “Once Again Me” means Once Again Me, Inc., a California
corporation, which was acquired by Borrower pursuant to the Once Again Me Stock Purchase Agreement. 
 “Once Again Me
Deposit Account” means Once Again Me’s Deposit Account, account number 80000379322, maintained with First Republic Bank which amount on deposit therein shall not exceed $500 at any time. 

  
 37 

 “Once Again Me Letter of Credit” means that certain Irrevocable Standby
Letter of Credit (No. SVBSF007213) in an amount not to exceed $400,000, dated December 21, 2011, issued by SVB in favor of the Shareholder Representative (as defined in the Once Again Me Stock Purchase Agreement) of Once Again Me. 

“Once Again Me Stock Purchase Agreement” means that certain Stock Purchase Agreement by and among Borrower, Once Again
Me, each of the shareholders of Once Again Me party thereto and Robert E. Grove as the shareholders’ representative, dated December 22, 2011. 
 “Once Again Me Indebtedness” means certain amounts constituting deferred purchase price owed by Borrower under the Once Again Me Stock Purchase Agreement in amount not to exceed $500,000.

 “Once Again Me Letter of Credit Collateral Account” means that certain cash collateral account, account
number 3300786056, of Borrower maintained at SVB which (i) serves as cash collateral for the Once Again Me Letter of Credit (ii) amount on deposit therein shall not exceed the face amount of the Once Again Me Letter of Credit at any time
and (iii) shall be closed upon the payment of the Once Again Me Indebtedness or return of the Once Again Me Letter of Credit to SVB, as applicable, and any amounts remaining therein shall be promptly transferred to a Collateral Account of
Borrower that is subject to a Control Agreement. 
 “Operating Documents” are, for any Person,
such Person’s formation documents, as certified with the Secretary of State of such Person’s state of formation on a date that is no earlier than 30 days prior to the Effective Date, and, (a) if such Person is a corporation, its
bylaws in current form, (b) if such Person is a limited liability company, its limited liability company agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar agreement), each of
the foregoing with all current amendments or modifications thereto. 
 “Ordinary Course of Business” means, in
respect of any transaction involving any Loan Party, the ordinary course of business of such Loan Party, as conducted by such Loan Party. 
 “Palomar Litigation” means Palomar Medical Technologies vs. TRIA Beauty, Inc., United States District Court for the District of Massachusetts (Case No. 09-cv-11081).

 “Partial Final Payment” means a payment (in addition to and not a substitution for the regular
monthly payments of accrued interest plus, if applicable, principal) owing to each Lender, with respect to each Term Loan made by such Lender due on the prepayment of a portion of a Term Loan pursuant to 2.1.1(d), equal to the amount of such Term
Loan so prepaid multiplied by the Final Payment Percentage. 
 “Patents” means all
patents, patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 

“Payment/Advance Form” is that certain form attached hereto as Exhibit B. 

“Payment Date” is defined in Section 2.3(f). 

“Perfection Certificate” is defined in Section 5.1 

“Permits” means licenses, certificates, accreditations, product clearances or approvals, provider numbers or provider
authorizations, marketing authorizations, other authorizations, registrations, permits, consents and approvals required in connection with the conduct of Borrower’s or any Subsidiary’s business or to comply with any applicable Laws,
including, without limitation, drug listings and drug establishment registrations under 21 U.S.C. Section 510, registrations issued by DEA under 21 U.S.C. Section 823 (if applicable to any Product), and those issued by State governments
for the conduct of Borrower’s or any Subsidiary’s business. 

  
 38 

 “Permitted Indebtedness” is: 

(a) Borrower’s Indebtedness to Agent and the Lenders under this Agreement and the other Loan Documents with respect to the
Obligations; 
 (b) Subordinated Debt; 
 (c) unsecured Indebtedness to trade creditors incurred in the Ordinary Course of Business and consistent with past practices; 
 (d) Indebtedness secured by Liens permitted under clauses (a) and (c) of the definition of “Permitted Liens” hereunder; 

(e) Indebtedness representing deferred compensation to employees not to exceed $100,000; 

(f) other Indebtedness not otherwise permitted by Section 7.4 not exceeding Two Hundred Fifty Thousand Dollars ($250,000) in the
aggregate outstanding at any time; 
 (g) until paid, the Once Again Me Indebtedness; and 

(h) Indebtedness in the form of intercompany loans that constitute Permitted Investments pursuant to clause (f) of the definition of
Permitted Investments, and subject to the limitations set forth therein, made by Borrower to one of its Subsidiaries; provided, that, to the extent that such Indebtedness is evidenced by a promissory note or other written instrument, Borrower
shall pledge and deliver to Agent, for the benefit of itself and the Lenders, the original promissory note or instrument, as applicable, along with an endorsement in blank in form and substance satisfactory to Agent. 

“Permitted Investments” are: 
 (a) Investments (including, without limitation, Subsidiaries) existing on the Effective Date and shown on the Perfection Certificate other than Investments held in the Securities Account of Borrower,
account number 19-sv816, maintained with SVB which is covered by clause (b) below of this definition; 
 (b) (i)
Investments consisting of Cash Equivalents and (ii) any Investments permitted by Borrower’s investment policy, if developed, as amended from time to time, provided that such investment policy (and any such amendment thereto) has been
approved in writing by Agent; 
 (c) Investments consisting of the endorsement of negotiable instruments for deposit or
collection or similar transactions in the ordinary course of Borrower; 
 (d) Investments consisting of Deposit Accounts in
which Agent has a perfected security interest; 
 (e) Investments by Borrower in Credit Party Subsidiaries; 

(f) Investments by Borrower in Subsidiaries whose Shares (i) have not been pledged to Agent for its benefit and the benefit of the
Lenders in accordance with this Agreement in an amount not to exceed, in any fiscal year, Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate for all such Investments and (ii) have been pledged to Agent for its benefit and the
benefit of the Lenders in accordance with this Agreement in an amount not to exceed, in any fiscal year, (x) Two Million Dollars ($2,000,000) for any such Subsidiary and (y) Three Million Dollars in the aggregate for all such Investments,
in all cases under either subclause (i) or (ii) to the extent that such Investments are made for reasonable business purposes and have been approved by Borrower’s Board of Directors; 

  
 39 

 (g) Investments consisting of (i) travel advances and employee relocation loans and
other employee loans and advances in the Ordinary Course of Business and consistent with past practices, and (ii) loans to employees, officers or directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant
to employee stock purchase plans or agreements approved by Borrower’s Board of Directors; 
 (h) Investments (including
debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the Ordinary Course of Business and
consistent with past practices; and 
 (i) Investments consisting of notes receivable of, or prepaid royalties and other credit
extensions, to customers and suppliers who are not Affiliates, in the Ordinary Course of Business and consistent with past practices; provided that this paragraph (j) shall not apply to Investments of Borrower in any Subsidiary. 

“Permitted Liens” are: 
 (a) Liens arising under this Agreement and the other Loan Documents; 
 (b) Liens
for taxes, fees, assessments or other government charges or levies, either (i) not due and payable or (ii) being contested in good faith and for which Borrower maintains adequate reserves on its books, provided that no notice of any
such Lien has been filed or recorded under the Internal Revenue Code of 1986, as amended, and the Treasury Regulations adopted thereunder; 
 (c) purchase money Liens (i) on Equipment acquired or held by Borrower incurred for financing the acquisition of the Equipment securing no more than Two Hundred Fifty Dollars ($250,000) in the
aggregate amount outstanding, or (ii) existing on Equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the Equipment; 

(d) Liens of carriers, warehousemen, suppliers, or other Persons that are possessory in nature arising in the Ordinary Course of Business
and consistent with past practices so long as such Liens attach only to the Inventory being held by such Person, securing liabilities in the aggregate amount not to exceed Two Hundred Fifty Dollars ($250,000) and which are not delinquent or remain
payable without penalty or which are being contested in good faith and by appropriate proceedings which proceedings have the effect of preventing the forfeiture or sale of the property subject thereto; 

(e) Liens on the Once Again Me Letter of Credit Collateral Account; 

(f) Liens to secure payment of workers’ compensation, employment insurance, old-age pensions, social security and other like
obligations incurred in the Ordinary Course of Business and consistent with past practices (other than Liens imposed by ERISA); 

(g) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (c),
but any extension, renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness may not increase; 

(h) leases or subleases of real property granted in the ordinary course of Borrower’s business (or, if referring to another Person,
in the ordinary course of such Person’s business), and leases, subleases, non-exclusive licenses or sublicenses of personal property (other than Intellectual Property) granted in the ordinary course of Borrower’s business (or, if referring
to another Person, in the ordinary course of such Person’s business), if the leases, subleases, licenses and sublicenses do not prohibit granting Agent a security interest therein; 

(i) easements, reservations, rights of way, restrictions, minor defects or irregularities in title or similar changes or encumbrances
affecting real property not constituting a Material Adverse Change; 
 (j) non-exclusive licenses of Intellectual Property
granted to third parties in the Ordinary Course of Business, and licenses of Intellectual Property that could not result in a legal transfer of title of the licensed property that may be exclusive in respects other than territory and that may be
exclusive as to territory only as to discreet geographical areas outside of the United States; 

  
 40 

 (k) Liens arising from attachments or judgments, orders, or decrees in circumstances not
constituting an Event of Default under Sections 8.4 and 8.7; and 
 (l) banker’s liens and rights of setoff in favor of
financial institutions incurred made in the Ordinary Course of Business and consistent with past practices arising in connection with Borrower’s Deposit Accounts or Securities Accounts held at such institutions to secure payment of fees and
similar costs and expenses subject to Borrower’s compliance with Section 6.6(b) hereof. 
 “Person”
is any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity
or government agency. 
 “Prepayment Fee” means with respect to a Term Loan subject to prepayment prior to the
Maturity Date, whether by mandatory or voluntary prepayment, acceleration or otherwise, an additional fee payable to the Lenders in an amount equal to: 
 (a) for a prepayment in respect of any Term Loan owing to such Lender made on or after the Effective Date through and including the date which is twelve (12) months after the Effective Date, three
percent (3.0%) multiplied by, in the case of a prepayment of an entire Term Loan, the outstanding principal amount of such Term Loan and, in the case of a prepayment of a portion of a Term Loan, the amount of the outstanding principal of
such Term Loan prepaid; and 
 (b) for a prepayment in respect of any Term Loan owing to such Lender made after the date which
is twelve (12) months after the Effective Date and prior to the Maturity Date, two percent (2.0%) multiplied by, in the case of a prepayment of an entire Term Loan, the outstanding principal amount of such Term Loan and, in the case
of a prepayment of a portion of a Term Loan, the amount of the outstanding principal of such Term Loan prepaid. 

“Products” means any products manufactured, sold, developed, tested or marketed by any Borrower or any of its
Subsidiaries, including without limitation, those products set forth on Perfection Certificate (as updated from time to time in accordance this Agreement); provided, however, that if Borrower shall fail to comply with the obligations under this
Agreement to give notice to Agent and update the Perfection prior to manufacturing, selling, developing, testing or marketing any new Product, any such improperly undisclosed Product shall be deemed to be included in this definition; and provided,
further, that products manufactured by Borrower for unaffiliated third parties shall not be deemed “Products” hereunder. 
 “Pro Rata Share” means, as determined by Agent, with respect to each Lender, a percentage (expressed as a decimal, rounded to the ninth decimal place) determined by dividing the
amount of Term Loans held by such Lender by the aggregate amount of all outstanding Term Loans. 
 “Registered
Organization” is any “registered organization” as defined in the Code with such additions to such term as may hereafter be made. 
 “Required Lenders” means Lenders having (a) more than 75% of the Term Loan Commitments of all Lenders, or (b) if such Term Loan Commitments have expired or been terminated, more
than 75% of the aggregate outstanding principal amount of the Term Loans; provided, however, that so long as a party that is a Lender hereunder on the Effective Date does not assign any portion of its Term Loan Commitment or Term Loan to any
Person other than an Affiliate, the term “Required Lenders” shall include such Lender (and any Affiliate to which it assigns its interests). For purposes of this definition only, a Lender shall be deemed to include itself, and any
Lender that is an Affiliate or Approved Fund of such Lender. 
 “Required Permit” means a Permit
(a) issued or required under Laws applicable to the business of Borrower or any of its Subsidiaries or necessary in the manufacturing, importing, exporting, possession, ownership, warehousing, marketing, promoting, sale, labeling, furnishing,
distribution or delivery of goods or services under 

  
 41 

 
Laws applicable to the business of Borrower or any of its Subsidiaries or any Drug Application (including without limitation, at any point in time, all licenses, approvals and permits issued by
the FDA or any other applicable Governmental Authority necessary for the testing, manufacture, marketing or sale of any Product by any applicable Borrower(s) as such activities are being conducted by such Borrower with respect to such Product at
such time), and (b) issued by any Person from which Borrower or any of their Subsidiaries have received an accreditation. 

“Requirement of Law” is as to any Person, the organizational or governing documents of such Person, and any Law
(statutory or common), treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its
property is subject. 
 “Responsible Officer” is any of the President, Chief Executive Officer, or Chief
Financial Officer of Borrower acting alone. 
 “Restricted License” is any material license or other agreement
with respect to which Borrower is the licensee (a) that prohibits or otherwise restricts Borrower from granting a security interest in Borrower’s interest in such license or agreement or any other property, or (b) for which a default
under or termination of could interfere with the Agent’s right to sell any Collateral. 
 “Revenues” shall
mean revenues, as calculated in accordance with generally acceptable accounting principles, using principles applied as applied as of the Effective Date. 
 “SBIC Letter Agreement” means that certain letter agreement dated as of the date hereof executed by Borrower in favor of Agent. 

“SEC” shall mean the Securities and Exchange Commission, any successor thereto, and any analogous Governmental
Authority. 
 “Secured Promissory Note” has the meaning given it in Section 2.6. 

“Secured Promissory Note Record” means a record maintained by each Lender with respect to the outstanding Obligations
and credits made thereto. 
 “Securities Account” is any “securities account” as defined in the Code
with such additions to such term as may hereafter be made. 
 “Shares” means (i) one hundred percent
(100%) of the issued and outstanding capital stock, membership units or other securities owned or held of record by Borrower in any Subsidiary; provided, that, solely with respect to Foreign Subsidiaries, “Shares” shall be limited to
sixty-six percent (66%) of the issued and outstanding capital stock, membership units or other securities owned or held of record by Borrower in any Foreign Subsidiary if the pledge of 100% of such issued and outstanding capital stock,
membership units or other securities would cause a material increase in the Borrower’s federal income tax liability. 

“Subordinated Debt” means indebtedness (i) incurred by Borrower on terms and conditions, in amounts, with lenders
and pursuant to documentation acceptable to Agent and the Required Lenders and (ii) subordinated to all of Borrower’s now or hereafter Indebtedness to the Lenders (pursuant to a subordination, intercreditor, or other similar agreement in
form and substance satisfactory to Agent and the Required Lenders entered into between Agent, Borrower and the other creditor), on terms and conditions acceptable to Agent and the Required Lenders. 

“Subsidiary” is, (a) as to any Person, a corporation, partnership, limited liability company or other entity of
which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests having such power only by reason of the happening of a contingency) to elect a majority of the board of directors or
other managers of such corporation, partnership or other entity are at the time owned, (b) as to any Person, the management of which is otherwise controlled, directly or indirectly through one or more intermediaries, or both, by such Person or
one or more Affiliates of such Person or (c) as to any Person , more than 50.0% of the voting stock or other equity interests (in the case or Persons other than corporations) is owned or 

  
 42 

 
controlled, directly or indirectly through one or more intermediaries, or both, by such Person or one or more Affiliates of such Person. Unless the context otherwise requires, each reference to a
Subsidiary herein shall be a reference to a Subsidiary of Borrower. 
 “SVB” means Silicon Valley Bank, a
California corporation. 
 “Term Loan” is defined in Section 2.1.1(a)(ii) hereof. 

“Term Loan Advances” means collectively the Term A Loan Advance and the Term B Loan Advance. 

“Term A Loan” is defined in Section 2.1.1(a)(i) hereof. 

“Term A Loan Advance” means the amounts advanced to Borrower by the Lenders on the Funding Date of the Term A Loan.

 “Term B Loan” is defined in Section 2.1.1(a)(ii) hereof. 

“Term B Loan Advance” means the amounts advanced to Borrower by the Lenders on the Funding Date of the Term B Loan.

 “Term Loan Commitment” means, for any Lender, the obligation of such Lender to make a Term Loan, up to the
principal amount shown on Schedule 1. “Term Loan Commitments” means the aggregate amount of such commitments of all Lenders. 
 “Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same and like protections, and the entire goodwill of
the business of Borrower connected with and symbolized by such trademarks. 
 “Transfer” is defined in
Section 7.1. 
 “Treasury Note Maturity” is thirty six (36) months. 

“Tria” is defined in the preamble hereof. 
 “Tria Japan” is Tria Beauty Japan K.K., a wholly owned Subsidiary of Borrower organized under the Laws of Japan. 
 “Tria Korea” is Tria Beauty Korea Limited, a wholly owned Subsidiary of Borrower organized under the Laws of Korea. 

“Tria U.K.” is Tria Beauty UK Ltd., a wholly owned Subsidiary of Borrower organized under the Laws of the United
Kingdom. 
 “U.K. Share Pledge Documents” is a share pledge agreement under the Laws of the United Kingdom or
the appropriate local jurisdiction within the United Kingdom as determined by local English counsel, minutes of board of directors and related documents, request to update the shareholders registry, updated shareholders registry, seal certificate
and any other documents reasonably requested by Agent with respect to the pledge by Borrower to Agent of the issued and outstanding Shares of Tria U.K. pursuant to the Laws of the jurisdiction of Tria U.K.’s formation. 

“Warrants” are (i) the Effective Date Warrants and (ii) any Warrants executed by Borrower in favor of the
applicable Lender after the Effective Date in connection with the making of the Term B Loan. 
 [Signature page
follows.] 

  
 43 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as
of the Effective Date. 
  

			
	BORROWER:
	
	TRIA BEAUTY, INC.
		
	By	 	 /s/ Kevin J. Appelbaum

	Name:	 	Kevin J. Appelbaum
	Title:	 	President and Chief Executive Officer

  
 LOAN AND
SECURITY AGREEMENT 
 SIGNATURE PAGE 

							
	AGENT:
	
	MIDCAP FINANCIAL SBIC, LP, as Agent for the Lenders
			
	By:	 	MidCap Financial SBIC GP, LLC	 	
			
	By:	 	 /s/ Josh Groman
	 	
	Name:	 	 Josh Groman
	 	
	Title:	 	 Managing Director
	 	Authorized Signatory

  
 LOAN AND
SECURITY AGREEMENT 
 SIGNATURE PAGE 

							
	LENDERS:
	
	MIDCAP FINANCIAL SBIC, LP, as a Lender
			
	By:	 	MidCap Financial SBIC GP, LLC	 	
			
	By:	 	 /s/ Josh Groman
	 	
	Name:	 	 Josh Groman
	 	
	Title:	 	 Managing Director
	 	Authorized Signatory

 Address for notices: 
 MidCap Financial SBIC, LP 
 7255 Woodmont Avenue, Suite 200 

Bethesda, Maryland 20814 
 Attention: Portfolio
Management- Life Sciences 
 Fax: (301) 941-1450 
 E-Mail: lviera@midcapfinancial.com 

  
 LOAN AND
SECURITY AGREEMENT 
 SIGNATURE PAGE 

			
	SILICON VALLEY BANK, as a Lender
		
	By	 	 /s/ Benjermin Colombo

	Name:	 	 Benjermin Colombo

	Title:	 	 SR Manager

 Address for notices: 
 555 Mission Street, Suite 900 
 San Francisco, CA 94105 

Attention: Benjermin Colombo 
 Fax:
(415) 615-0076 
 E-mail: bcolombo@svb.com 

  
 LOAN AND
SECURITY AGREEMENT 
 SIGNATURE PAGE 

			
	GENERAL ELECTRIC CAPITAL CORPORATION, as a Lender
		
	By	 	 /s/ Peter Gibson

	Name:	 	 Peter Gibson

	Title:	 	Its Duly Authorized Signatory

 Address for notices: 
 General Electric Capital Corporation 
 c/o GE Healthcare Financial Services, Inc. 

Two Bethesda Metro Center, Suite 600 
 Bethesda,
Maryland 20814 
 Attention: Senior Vice President of Risk – Life Science Finance 
 Phone: (301) 961-1640 
 Facsimile: (301) 664-9855 

With a copy to: 
 General Electric Capital
Corporation 
 c/o GE Healthcare Financial Services, Inc. 
 Two Bethesda Metro Center, Suite 600 
 Bethesda, Maryland 20814 

Attention: General Counsel 
 Phone:
(301) 961-1640 
 Facsimile: (301) 664-9866 

  
 LOAN AND
SECURITY AGREEMENT 
 SIGNATURE PAGE 

 EXHIBITS AND SCHEDULES 
 EXHIBITS

			
		
	 Exhibit A
	  	Collateral Description
	 Exhibit B
	  	Loan Payment / Advance Request Form
	 Exhibit C
	  	Compliance Certificate
	 Exhibit D
	  	Secured Promissory Note
	 Exhibit E
	  	Form of Warrant

SCHEDULES 

			
		
	 Schedule 1
	  	Lenders and Commitments

 SCHEDULE 1 

LENDERS AND COMMITMENTS 
  

																	
	 Lender
	  	Term A Loan
Commitment	 	  	Term B Loan
Commitment	 	  	Total Term
Loan
Commitment	 	  	Total Term Loan
Commitment
Percentage	 
	 MidCap Financial SBIC, LP
	  	$	7,777,778	  	  	$	2,722,222	  	  	$	10,500,000	  	  	 	38.8888	% 
	 Silicon Valley Bank
	  	$	6,666,667	  	  	$	2,333,333	  	  	$	9,000,000	  	  	 	33.3333	% 
	 General Electric Capital Corporation
	  	$	5,555,555	  	  	$	1,944,445	  	  	$	7,500,000	  	  	 	27.7777	% 
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 TOTAL
	  	$	20,000,000	  	  	$	7,000,000	  	  	$	27,000,000	  	  	 	100	% 
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 

 EXHIBIT A – COLLATERAL DESCRIPTION 

The Collateral consists of all assets of Borrower, now owned or hereafter acquired and regardless of location, including all of
Borrower’s right, title and interest in and to the following personal property: 
 (a) all goods, Accounts (including
health-care insurance receivables), Equipment, Inventory, contract rights or rights to payment of money, leases, license agreements, franchise agreements, General Intangibles, commercial tort claims (as more specifically identified on Schedule A-1
attached to this Exhibit), documents, instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, Deposit Accounts, investment accounts, Commodity Accounts and other Collateral Accounts, all certificates of
deposit, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired,
wherever located; and 
 (b) all Borrower’s Books relating to the foregoing, and any and all claims, rights and interests
in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the foregoing. 

Notwithstanding the foregoing, the Collateral shall not include any Intellectual Property of any Loan Party, whether now owned or
hereafter acquired, except to the extent that it is necessary under applicable Law to have a Lien and security interest in any such Intellectual Property in order to have a perfected Lien and security interest in and to IP Proceeds (defined below),
and for the avoidance of any doubt, the Collateral shall include, and Agent shall have a Lien and security interest in, (i) all IP Proceeds, and (ii) all payments with respect to IP Proceeds that are received after the commencement of a
bankruptcy or insolvency proceeding. The term “IP Proceeds” means, collectively, all cash, Accounts, license and royalty fees, claims, products, awards, judgments, insurance claims, and other revenues, proceeds or income,
arising out of, derived from or relating to any Intellectual Property of any Loan Party, and any claims for damage by way of any past, present or future infringement of any Intellectual Property of any Loan Party (including, without limitation, all
cash, royalty fees, other proceeds, Accounts and General Intangibles that consist of rights of payment to or on behalf of a Loan Party and the proceeds from the sale, licensing or other disposition of all or any part of, or rights in, any
Intellectual Property by or on behalf of a Loan Party). 
 Agent and Lenders further acknowledge that the Collateral shall not
include more than 66% of the voting securities of any Subsidiary that is not organized under the Laws of the United States or any of its states if such pledge would cause a material increase in the Borrower’s federal income tax liability.

 Pursuant to the terms of a certain negative pledge arrangement with Agent and Lenders, Borrower has agreed not to encumber
any of its Intellectual Property without Agent’s and Lenders’ prior written consent. 

 SCHEDULE A-1 

COMMERCIAL TORT CLAIMS 
 1. A lawsuit, TRIA Beauty, Inc. v. Radiancy, Inc., Case No. 10-cv-05030, filed by Borrower in November 2010 in the United States District Court for the Northern District of California against
Radiancy, Inc., maker of the no!no! Hair hair-removal device, asserting that Radiancy has engaged in false advertising, trademark infringement and unfair competition, and seeking money damages and injunctive relief; the complaint was amended by
Borrower in June 2011 to add a claim regarding Radiancy’s advertising for its no!no! Skin acne-treatment product. 
 2. A lawsuit, TRIA
Beauty, Inc. v. Oregon Aesthetic Technologies, Inc., Case No. 10-cv-05053, filed by Borrower on November 8, 2010 in the United States District Court for the Northern District of California against Oregon Aesthetic Technologies
(“OAT”), asserting that OAT engaged in unfair competition and false advertising and seeking money damages and injunctive relief. On March 10, 2011, the suit was stayed in favor of the suit filed by OAT against Borrower, Oregon
Aesthetic Technologies, Inc. v. TRIA Beauty, Inc., Case No. 10-cv-1362, in United States District Court for the District of Oregon. In the Oregon suit, Borrower filed an Answer and Counterclaim on March 3, 2011, alleging that OAT engaged
in unfair competition and false advertising, and seeking money damages and injunctive relief. On December 12, 2011, the California court entered an order transferring the California case to the District of Oregon. On January 3, 2012,
Borrower filed an unopposed motion to consolidate the California and Oregon cases. 

 EXHIBIT B – LOAN PAYMENT/ADVANCE REQUEST FORM 

DEADLINE FOR SAME DAY PROCESSING IS
2:00PM EASTERN TIME* 
  

			
	Fax To:	  	Date:                    

  

									
	LOAN PAYMENT:
	TRIA BEAUTY, INC.
					
	From Account #	 	  
	 		 	To Account #	 	  

		 	(Deposit Account #)	 		 		 	(Loan Account #)
					
	Principal $	 	  
	 		 	and/or Interest $	 	  

					
	Authorized Signature:	 	  
	 		 	        Phone Number:	 	  

	Print Name/Title:	 	  
	 		 		 	

  

											
	LOAN ADVANCE:
	
	Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are for an outgoing wire.
					
	From Account #	 	  
	 		 	To Account #	 	  

		 	(Loan Account #)	 		 		 	(Deposit Account #)
						
	Amount of Advance $	 	  
	 		 		 		 	
	
	All Borrower’s representations and warranties in the Loan and Security Agreement are true, correct and complete in all material respects on the date of the request
for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those
representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date:
						
	Authorized Signature:	 	  
	 		 	Phone Number:	 	  
	 	
	Print Name/Title:	 	  
	 		 		 		 	

  

											
	OUTGOING WIRE REQUEST:
	Complete only if all or a portion of funds from the loan advance above is to be wired.	  	
	Deadline for same day processing is 2:00pm, Eastern Time	  	
					
	Beneficiary Name:	  	  
	 		 	Amount of Wire: $	  	  

	Beneficiary Bank:	  	  
	 		 	Account Number:	  	  

	City and State:	  	  
	 		 		  		  	

  

													
	Beneficiary Bank Transit (ABA) #:	 	  
	 		  	Beneficiary Bank Code (Swift, Sort, Chip, etc.):	  	  

		  		 		 		  	        (For International Wire Only)	  	

  

									
	Intermediary Bank:	  	  
	 		 	Transit (ABA) #:	  	  

	For Further Credit to:	  	  

		
	Special Instruction:	  	  

  

									
	By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in accordance with and subject to the terms and conditions set
forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me (us).
					
	Authorized Signature:	  	  
	 		 	2nd Signature (if required):	  	  

	Print Name/Title:	  	  
	 		 	Print Name/Title:	  	  

	Telephone #:	  	  
	 		 	Telephone #:	  	  

  
  

	*	Unless otherwise provided for an Advance bearing interest at LIBOR. 

  
 1 

 EXHIBIT C 

COMPLIANCE CERTIFICATE 
  

					
	TO:	 	MIDCAP FINANCIAL SBIC, LP, as Agent	  	Date:                     
	FROM:	 	TRIA BEAUTY, INC.	  	

 The undersigned authorized officer of TRIA BEAUTY, INC. (“Borrower”) certifies that under the
terms and conditions of the Loan and Security Agreement between Borrower, Agent and the Lenders (the “Agreement”): 

(1) Borrower is in complete compliance for the period ending
                    with all required covenants except as noted below; (2) there are no Events of Default; (3) neither Borrower nor any
Subsidiary of Borrower owns or carries any margin stock (under Regulations X, T and U of the Federal Reserve Board of Governors), and (4) all representations and warranties in the Agreement and the other Loan Documents including the Perfection
Certificate as updated from time to time as permitted by the Agreement are true and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any
representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in
all material respects as of such date. 
 Attached are the required documents supporting the certifications set forth in this
Compliance Certificate. The undersigned certifies, in his/her capacity as an officer of the Borrower, that these are prepared in accordance with GAAP consistently applied from one period to the next except as explained in an accompanying letter or
footnotes. The undersigned acknowledges, in his/her capacity as an officer of Borrower, that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of the Agreement, and that
compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Agreement. 
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

					
	 Reporting Covenant
	  	 Required
	  	 Complies

			
	 Monthly/Quarterly financial statements with
 Compliance Certificate
	  	Monthly within 30 days	  	Yes    No
	Annual financial statement (CPA Audited) + CC	  	FYE within 120 days	  	Yes    No
	Board Projections	  	By earlier or January 31 or within 7 days after Board of Directors’ approval	  	Yes    No

  

													
	 Financial Covenant
	  	Required	 	  	Actual	 	  	Complies	 
				
	 Maintain on a Monthly Basis:
	  				  				  			
				
	 Minimum Net Sales
	  	$	            	  	  	$	            	  	  	 	Yes     No	  

  
 1 

 The following are the exceptions with respect to the certification above: (If no exceptions
exist, state “No exceptions to note.”) 
  

	
	  

	  

	  

  

									
	TRIA BEAUTY, INC.	 		 	AGENT USE ONLY
					
		 		 		 	Received by:	 	  

	By:	 	  
	 		 		 	AUTHORIZED SIGNER
	Name:	 	  
	 		 	Date:	 	  

	Title:	 	  
	 		 		 	
		 		 		 	Verified:	 	  

		 		 		 		 	AUTHORIZED SIGNER
		 		 		 	Date:	 	  

									
					
		 		 		 	Compliance Status:	  	 Yes    No

  
 2 

 EXHIBIT D 
 FORM OF SECURED PROMISSORY NOTE 
 SECURED PROMISSORY NOTE 

 

			
	$        ,000,000.00	 	January 25, 2012

 FOR VALUE RECEIVED, TRIA BEAUTY, INC., a Delaware corporation ( “Borrower”)
hereby promises to pay to
                                    , or its registered
assigns (“Lender”), with an address of
                                        ,
or such other place of payment as the holder of this Secured Promissory Note (this “Promissory Note”) may specify from time to time in writing, in lawful money of the United States of America, the principal amount of
         Million and No/100 Dollars ($        ,000,000.00), or such other principal amount as Lender has advanced to Borrower pursuant to the Loan
Agreement (as hereinafter defined), together with interest (including interest at the Default Rate, if applicable) in accordance with the Loan Agreement based upon a year consisting of 360 days, with interest computed daily based on the actual
number of days elapsed until the principal balance is paid in full. 
 This Promissory Note is executed and delivered in
connection with that certain Loan and Security Agreement of even date herewith by and among Borrower, MidCap Financial SBIC, LP, as agent for Lenders, and Lender, and the other lenders named therein from time to time (as the same may from time to
time be amended, modified, restated or supplemented in accordance with its terms, the “Loan Agreement”), and is entitled to the benefit and security of the Loan Agreement and the other Loan Documents (as defined in the Loan
Agreement), to which reference is made for a statement of all of the terms and conditions thereof. All payments shall be made in accordance with the Loan Agreement. All terms defined in the Loan Agreement shall have the same definitions when used
herein, unless otherwise defined herein. An Event of Default under the Loan Agreement shall constitute a default under this Promissory Note, and upon any such Event of Default, all principal and interest and other obligations owing under this
Promissory Note may be accelerated and declared immediately due and payable as provided for in the Loan Agreement. Reference to the Loan Agreement shall not affect or impair the absolute and unconditional obligation of Borrower to pay all principal
and interest and premium, if any, under this Promissory Note as otherwise provided herein. 
 Borrower waives presentment and
demand for payment, notice of dishonor, protest and notice of protest under the Uniform Commercial Code as in effect in the State of California or any applicable law. Borrower agrees to make all payments under this Promissory Note without setoff,
recoupment or deduction and regardless of any counterclaim or defense. This Promissory Note has been negotiated and delivered to Lender and is payable in the State of California. This Promissory Note shall be governed by and construed and enforced
in accordance with, the laws of the State of California, excluding any conflicts of law rules or principles that would cause the application of the laws of any other jurisdiction. Without limiting the generality of the preceding paragraph, the
provisions of Section 11 of the Loan Agreement regarding jurisdiction, venue and jury trial waiver are incorporated herein. 

[SIGNATURES APPEAR ON THE FOLLOWING PAGE] 

  
 3 

 IN WITNESS WHEREOF, Borrower, as of the day and year first above written, has caused this
Promissory Note to be executed under seal 
  

					
	TRIA BEAUTY, INC.	 	
			
	By:	 	 	 	(SEAL)
	Name:	 	 	 	
	Title:	 	 	 	

 [Signature Page to Secured Promissory Note] 

 EXHIBIT E 
 FORM OF WARRANT 
 [See Exhibit 4.4 to the Registration Statement] 

  
 4 

 EXECUTION VERSION 
 AMENDED AND RESTATED FIRST AMENDMENT TO 
 LOAN AND SECURITY AGREEMENT

 THIS AMENDED AND RESTATED FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”) is
dated as of May 7, 2012, by and among TRIA BEAUTY, INC., a Delaware corporation (“Borrower”), MIDCAP FINANCIAL SBIC, LP, a Delaware limited partnership in its capacity as agent (“Agent”) for the
lenders under the Loan Agreement (as defined below) (“Lenders”), and the Lenders signatory hereto. 

W I T N E S S E T H: 

WHEREAS, Borrower, Lenders and Agent are parties to that certain Loan and Security Agreement, dated as of January 25, 2012,
as amended by the First Amendment (as defined below) (as further amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”; capitalized terms used herein have the meanings given to them in the
Loan Agreement except as otherwise expressly defined herein), pursuant to which Lenders have agreed to provide to Borrower certain loans and other extensions of credit in accordance with the terms and conditions thereof; 

WHEREAS, Borrower, Lenders and Agent are parties to that certain Closing Date Letter Agreement, dated as of January 25, 2012
(as amended, restated, supplemented or otherwise modified from time to time, the “Closing Date Letter Agreement”), pursuant to which Agent, Lenders and Borrower have agreed to certain terms and conditions with respect to the credit
facilities provided to Borrower under the Loan Agreement; 
 WHEREAS, Borrower, Lenders and Agent are parties to that
certain First Amendment to Loan and Security Agreement, dated as of May 2, 2012 (as amended, restated, supplemented or otherwise modified from time to time, the “First Amendment”), pursuant to which Borrower, Lenders and Agent
agreed to certain amendments and modifications to the Loan Agreement; 
 WHEREAS, Borrower, Agent and Lenders desire to
(i) amend and restate the First Amendment and (ii) terminate the Closing Date Letter Agreement, in each case, in accordance with, and subject to, the terms and conditions set forth herein. 

NOW, THEREFORE, in consideration of the premises, the covenants and agreements contained herein, and other good and valuable
consideration, the receipt and adequacy of which are hereby acknowledged, Borrower, Lenders and Agent hereby agree as follows: 

1. Acknowledgment of Obligations. Borrower hereby acknowledges, confirms and agrees that all Term Loans made prior
to the date hereof, together with interest accrued and accruing thereon, and fees, costs, expenses and other charges owing by Borrower to Agent and Lenders under the Loan Agreement, as amended hereby, and the other Loan Documents, are
unconditionally owing by Borrower to Agent and Lenders, without offset, defense or counterclaim of any kind, nature or description whatsoever except as may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or other similar
laws relating to or affecting creditor’s rights generally. 

 2. Amendments to Loan Agreement and Termination of Closing Date Letter
Agreement.  
 (a) Subject to the terms and conditions of this Amendment, including, without limitation, the conditions
to effectiveness set forth in Section 5 below, the Loan Agreement is amended as follows: 
 (i)
Section 6.7 of the Loan Agreement is hereby amended by deleting such section in its entirety and by inserting, in lieu thereof, the following: 
 “6.7 Financial Covenant. 
 (a) Commencing with
the month ending December 31, 2011, and continuing as of the last day of each calendar month thereafter, have minimum Net Sales, tested as of the last day of each month for the prior twelve month period of at least the minimum Net Sales agreed
upon in writing by the parties hereto; provided, that immediately upon the occurrence of the IPO Trigger Event, Borrower shall no longer be required to comply with this minimum Net Sales covenant; and 

(b) Immediately upon the occurrence of the IPO Trigger Event and at all times thereafter, have a minimum Liquidity of
greater than the greater of (i) fifteen million dollars ($15,000,000) and (ii) one hundred and ten percent (110%) of the amount of the outstanding Term Loans.” 

(ii) Section 14.1 of the Loan Agreement is hereby amended by adding the following new definitions in the
appropriate alphabetical order in such section: 
 “IPO Trigger Event” means the date on which Agent determines
that Borrower has delivered to Agent and Lenders evidence in form and substance reasonably satisfactory to Agent that Borrower has received cash proceeds from an underwritten primary public offering of the common capital stock of Tria Beauty, Inc.
pursuant to an effective registration statement filed with the SEC in accordance with the Securities Act (other than a public offering pursuant to a registration statement on Form S-8 (or any successor form)). 

“Liquidity” means unrestricted cash and Cash Equivalents on hand in a Collateral Account located at Silicon Valley Bank
or one of its affiliates and subject to a Control Agreement. 
 “Securities Act” means the Securities Act of
1933, as amended from time to time, and the rules and regulations promulgated thereunder. 

  
 -2-

 (iii) Section 14.1 of the Loan Agreement is hereby amended by
modifying the definition of Prepayment Fee by replacing the reference to “three percent (3.0%)” with “five percent (5.0%)”. 
 (iv) Exhibit C of the Loan Agreement is hereby amended by deleting such Exhibit in its entirety and replacing such Exhibit with the Exhibit C attached to this Amendment. 

(b) Subject to the terms and conditions of this Amendment, including, without limitation, the conditions to effectiveness set forth in
Section 5 below, and upon the occurrence of an IPO Trigger Event (as such term is defined in Section 2(a) above), the Closing Date Letter Agreement will automatically be terminated. 

3. No Other Amendments. Except for the amendments and other agreements set forth and referred to in
Section 2 above, the Loan Agreement and the other Loan Documents shall remain unchanged and in full force and effect and Borrower hereby ratifies and reaffirms all of its obligations under the Loan Agreement and the other Loan Documents
as amended by this Amendment. Nothing in this Amendment is intended, or shall be construed, to constitute a novation or an accord and satisfaction of any of Borrower’s Obligations or to modify, affect or impair the perfection or continuity of
Agent’s security interests in, security titles to or other liens, for the benefit of itself and the Lenders, on any Collateral for the Obligations. 
 4. Representations and Warranties. To induce Agent and Lenders to enter into this Amendment, Borrower does hereby warrant, represent and covenant to Agent and Lenders that
(i) each representation or warranty of Borrower set forth in the Loan Agreement is hereby restated and reaffirmed as true, correct and complete in all material respects on and as of the date hereof as if such representation or warranty were
made on and as of the date hereof; provided, however, that (A) such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof and (B) those
representations and warranties expressly referring to a specific date shall be true, correct and complete in all material respects as of such date, (ii) no Default or Event of Default has occurred and is continuing as of the date hereof and
(iii) Borrower has the power and is duly authorized to enter into, deliver and perform this Amendment and this Amendment is the legal, valid and binding obligation of Borrower enforceable against Borrower in accordance with its terms, except as
enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws relating to or affecting creditor’s rights generally. 
 5. Condition Precedent to Effectiveness of this Amendment. This Amendment shall become effective as of the date (the “Amendment Effective Date”) upon which Agent
shall notify Borrower in writing that each of the following conditions have been satisfied in a manner, and in form and substance, satisfactory to Agent: 
 (a) Agent shall have received one or more counterparts of this Amendment duly executed and delivered by Borrower, Agent and Lenders; 

  
 -3-

 (b) Agent shall have received an amendment fee in an amount equal to $67,500 for the benefit
of the Lenders in accordance with their respective Pro Rata Shares which amendment fee shall be fully earned and nonrefundable when paid; and 
 (c) Agent shall have received such other agreements, assurances, certificates, documents, consents or opinions as Agent may require. 

6. Release. 
 (a) In consideration of the agreements of Agent and Lenders contained herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, Borrower, on behalf
of itself and each of its Affiliates and Subsidiaries and each of their respective successors, assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each
Lender and their respective successors and assigns, and their respective present and former shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives (Agent, Lenders
and all such other persons being hereinafter referred to collectively as the “Releasees” and individually as a “Releasee”), of and from all demands, actions, causes of action, suits, covenants, contracts,
controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever (individually, a “Claim” and
collectively, “Claims”) of every name and nature, both at law and in equity, which Borrower or any of its successors, assigns, or other legal representatives may own, hold, have or claim to have against the Releasees or any of them
for, upon, or by reason of any circumstance, action, cause or thing whatsoever which arises at any time on or prior to the Amendment Effective Date, including, without limitation, for or on account of, or in relation to, or in any way in connection
with the Loan Agreement or any of the other Loan Documents or transactions thereunder or related thereto. 
 (b) Borrower
understands, acknowledges and agrees that its release set forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit or other proceeding which may be instituted, prosecuted or
attempted in breach of the provisions of such release. 
 7. Covenant Not To Sue. Borrower, on behalf of
itself and its successors, assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably, covenants and agrees with and in favor of each Releasee that it will not sue (at law, in equity, in any regulatory proceeding or
otherwise) any Releasee on the basis of any Claim released, remised and discharged by Borrower pursuant to Section 6 above. If Borrower or any of its successors, assigns or other legal representatives violates the foregoing covenant,
Borrower, for itself and its successors, assigns and legal representatives, agrees to pay, in addition to such other damages as any Releasee may sustain as a result of such violation, all attorneys’ fees and costs incurred by any Releasee as a
result of such violation. 
 8. Advice of Counsel. Each of the parties represents to each other party
hereto that it has discussed this Amendment with its counsel. 

  
 -4-

 9. Severability of Provisions. In case any provision of or obligation
under this Amendment shall be invalid, illegal or unenforceable in any applicable jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall
not in any way be affected or impaired thereby. 
 10. Counterparts. This Amendment may be executed in
multiple counterparts, each of which shall be deemed to be an original and all of which when taken together shall constitute one and the same instrument. Delivery of an executed counterpart of this Amendment by facsimile transmission or electronic
transmission shall be as effective as delivery of a manually executed counterpart hereof. 
 11. GOVERNING
LAW. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA APPLICABLE TO CONTRACTS MADE AND PERFORMED IN SUCH STATE WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING CONFLICTS OF
LAWS. 
 12. Entire Agreement. The Loan Agreement as and when amended through this Amendment embodies the
entire agreement between the parties hereto relating to the subject matter thereof and supersedes all prior agreements, representations and understandings, if any, relating to the subject matter thereof. 

13. No Strict Construction, Etc. The parties hereto have participated jointly in the negotiation and drafting of
this Amendment. In the event an ambiguity or question of intent or interpretation arises, this Amendment shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise favoring or disfavoring any
party by virtue of the authorship of any provisions of this Amendment. Time is of the essence for this Amendment. 
 14.
Costs and Expenses. Borrower agrees to pay or reimburse upon demand for all Lender Expenses in connection with the preparation, negotiation, execution and delivery of this Amendment and any other Loan Documents or other agreements
prepared, negotiated, executed or delivered in connection with this Amendment or transactions contemplated hereby, in accordance with Section 2.4 of the Loan Agreement. 

[Remainder of page intentionally blank; signature pages follow.] 

  
 -5-

 IN WITNESS WHEREOF, the parties hereto have caused this Amended and Restated First
Amendment to Loan and Security Agreement to be duly executed and delivered as of the day and year specified at the beginning hereof. 
  

			
	BORROWER:
	
	TRIA BEAUTY, INC.
		
	By:	 	/s/ John J. Rangel
	Name:	 	John J. Rangel
	Title:	 	CFO

 TRIA BEAUTY, INC. 
 AMENDED AND RESTATED FIRST 
 AMENDMENT TO LOAN AND SECURITY AGREEMENT 

SIGNATURE PAGE 

 
			
	AGENT AND LENDERS:
	
	MIDCAP FINANCIAL SBIC, LP, as Agent and a Lender
		
	By:	 	MIDCAP FINANCIAL SBIC GP, LLC
		
	By:	 	/s/ Josh Groman
	Name:	 	Josh Groman
	Title:	 	Authorized Signatory

  

			
	SILICON VALLEY BANK, as a Lender
		
	By:	 	/s/ Shannon O’Brien
	Name:	 	Shannon O’Brien
	Title:	 	Senior Relationship Assoc.

  

			
	GENERAL ELECTRIC CAPITAL CORPORATION, as a Lender
		
	By:	 	/s/ Peter Gibson
	Name:	 	Peter Gibson
	Title:	 	Duly Authorized Signatory

 TRIA BEAUTY, INC. 
 AMENDED AND RESTATED FIRST 
 AMENDMENT TO LOAN AND SECURITY AGREEMENT 

SIGNATURE PAGE 

 EXHIBIT C 

COMPLIANCE CERTIFICATE 
  

					
	 TO:       MIDCAP FINANCIAL SBIC, LP, as Agent
	  	 	Date:                 	  
	 FROM: TRIA BEAUTY, INC.
	  			

 The undersigned authorized officer of TRIA BEAUTY, INC. (“Borrower”) certifies that under the
terms and conditions of the Loan and Security Agreement between Borrower, Agent and the Lenders (the “Agreement”): 

(1) Borrower is in complete compliance for the period ending
                     with all required covenants except as noted below; (2) there are no Events of Default; (3) neither Borrower nor
any Subsidiary of Borrower owns or carries any margin stock (under Regulations X, T and U of the Federal Reserve Board of Governors), and (4) all representations and warranties in the Agreement and the other Loan Documents including the
Perfection Certificate as updated from time to time as permitted by the Agreement are true and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any
representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in
all material respects as of such date. 
 Attached are the required documents supporting the certifications set forth in this
Compliance Certificate. The undersigned certifies, in his/her capacity as an officer of the Borrower, that these are prepared in accordance with GAAP consistently applied from one period to the next except as explained in an accompanying letter or
footnotes. The undersigned acknowledges, in his/her capacity as an officer of Borrower, that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of the Agreement, and that
compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Agreement. 
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

							
	 Reporting Covenant
	  	 Required
	  	Complies	 
	 Monthly/Quarterly financial statements with Compliance Certificate
	  	Monthly within 30 days	  	 	Yes    No	  
	 Annual financial statement (CPA Audited) + CC
	  	FYE within 120 days	  	 	Yes    No	  
	 Board Projections
	  	By earlier or January 31 or within 7 days after Board of Directors’ approval	  	 	Yes    No	  

  

													
	 Financial Covenant
	  	Required	 	  	Actual	 	  	Complies	 
	 Prior to IPO Trigger Event-
	  				  				  			
	 Maintain on a Monthly Basis:
	  				  				  			
	 Minimum Net Sales
	  	$	________	  	  	$	________	  	  	 	Yes    No	  
	 After IPO Trigger Event-
	  				  				  			
	 Maintain at all times:
	  				  				  			
	 Minimum Liquidity
	  	$	________	  	  	$	________	  	  	 	Yes    No	  

 The following are the exceptions with respect to the certification above: (If no exceptions
exist, state “No exceptions to note.”) 
  
  

 
  
  

 
  

									
	TRIA BEAUTY, INC.	 		 	AGENT USE ONLY
					
	By:	 	 	 		 	Received by:	 	 
	Name:	 	 	 		 		 	AUTHORIZED SIGNER
	Title:	 	 	 		 	Date:	 	 
		 		 		 	Verified:	 	 
		 		 		 		 	AUTHORIZED SIGNER
		 		 		 	Date:	 	 
				
		 		 		 	Compliance Status:    Yes    No

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