Document:

Extension letter with The Regents of the University of California

 Exhibit 10.10 
 This document has been redacted pursuant to a confidential treatment request. 
 The * symbol denotes redacted information. 
 June 1, 2006 
 James R. Henderson, Ph.D. 
 Licensing Officer 
 Office of Technology Management 
 University of California, San Francisco 
 185 Berry Street, Suite 4603 
 San Francisco, CA 94107 
 The Regents of the University of California 
 Box 1016 
 University of California 
 San Francisco, CA 94143-1016 
  

	 	Re:	Renewal of Exclusive License Agreement for Optical Sectioning Microscope, 

 dated July 30, 1993, as amended (the “License Agreement”) 
 Dear Mr. Henderson: 
 This is to confirm that, pursuant to our discussions, effective as of December 31, 2005, we have mutually agreed to renew the License Agreement
under its existing terms until [*]. 
 This is also to confirm that we are [*]. 
 Thank you very much for your time and cooperation with respect to this matter. We look forward to [*]. If you agree to the terms of this
letter, please sign below where indicated and return it to me. 
  

	
	 Very truly yours,

	
	/s/ Joseph J. Victor, Jr.
	Joseph J. Victor, Jr.
	Senior Vice President, Life Sciences

 We acknowledge and agree to the terms of this letter. 
  

			
	 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

		
	 By
	 	 /s/ Joel B. Kirschbaum

	 Name
	 	 Joel B. Kirschbaum

	 Title
	 	 Director, OTM

	 Date
	 	 6/1/06Management Agreement with Riverside Partners, Inc.

 Exhibit 10.11 
 MANAGEMENT AGREEMENT 
 This Management Agreement is made as of January 18, 2002 by and between
Applied Precision, LLC, a Delaware limited liability company (“APLLC”), and Riverside Partners, Inc., a Delaware Corporation (“Riverside”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed
to such terms in the Amended and Restated Limited Liability Company Agreement of Applied Precision Holdings, LLC (“APHLLC”) dated the date hereof (the “LLC Agreement”). 
 Introduction 
 APLLC wishes to retain Riverside to provide management services
to APLLC on an ongoing basis, and Riverside desires to provide management services to APLLC. 
 Section 1. Engagement. APLLC
hereby engages Riverside to provide management services to it, including but not limited to advising APLLC on the operation of its business, the marketing of its products and services, its long term strategy, methods to increase its value, and all
other matters relating to APLLC (the “Management Services”). Riverside hereby agrees to provide the Management Services to APLLC for the term set forth in this Agreement. The Management Services shall be provided at such times and places
as are reasonably acceptable to the parties hereto. 
 Section 2. Management Fee. 
 (a) Amount of Management Fee. APLLC shall pay Riverside a fee (the “Management Fee”) for all Management Services
provided, payable as set forth herein. The Management Fee shall be an annual amount of $150,000 until APHLLC distributes the Senior Preferred and Senior Preferred Return to Applied Precision, Inc. (“API”), and shall be an annual amount of
$250,000 thereafter (in each case prorated for any partial year) until the earliest to occur of (i) a Sale of the Company, or (ii) the consummation of a Public Offering of the equity interests of APLLC, APHLLC or any successor entity
thereto. 
 (b) Payment. The Management Fee shall accrue but shall not be payable until APHLLC distributes the First
Senior Preferred and First Senior Preferred Return to API, at which time all accrued amounts shall immediately be due and payable to Riverside. Following the distribution of the First Senior Preferred and First Senior Preferred Return, the
Management Fee will be payable in arrears on a quarterly basis (subject to proration), on the first day of each calendar quarter following the quarter for which payment is due (or earlier, in the case of termination under Section 4 prior to
such date). 
 Section 3. Expense Reimbursement. APLLC shall reimburse Riverside for its reasonable out-of-pocket expenses
incurred in performing Management Services, including without limitation travel, lodging and other similar items. 

 Section 4. Term. This Agreement shall terminate at such time as Riverside and its affiliates
collectively own, directly or indirectly, through any corporation or other entity, less than 25% of the equity interest in APLLC initially owned by them, provided that APLLC shall remain liable thereafter to Riverside for the payment of any
unreimbursed expenses incurred prior to termination and any accrued but unpaid Management Fees through the date of termination. 
 Section 5. Miscellaneous. This Agreement represents the entire agreement and understanding between the parties with respect to the matters covered herein, and may not be amended except by the written agreement of the parties.
This Agreement shall be governed by and construed in accordance with the laws of The Commonwealth of Massachusetts and shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns. This Agreement
may be executed in two or more counterparts, each of which shall be deemed to be an original but all of which shall constitute one and the same instrument. 
 [The remainder of this page in intentionally left blank.] 
  

 2 

 IN WITNESS WHEREOF, the undersigned have executed this Agreement as a sealed instrument as of the date
first above written. 
  

													
	 APPLIED PRECISION, LLC
	 		 		 	 RIVERSIDE PARTNERS, INC.
	 	
							
	 By
	 	 /s/ Ronald C. Seubert
	 	  	 		 	 By
	 	 /s/ David Belluck
	 	  
		 	 President
	 	 (Title)
	 		 		 	 V.P.
	 	 (Title)

  

 3Promissory Note in favor of Ronald C. Seubert

 Exhibit 10.12 
 PROMISSORY NOTE 
  

			
	 $300,000.00
	 	March 31, 2003

 FOR VALUE RECEIVED, the undersigned, Applied Precision Holdings, LLC, a Delaware limited liability company
(“Borrower”), promises to pay to the order of Ronald C. Seubert (the “Lender”), at 1040 12th Avenue NW, Issaquah, WA 98027-8929, the principal sum of Three Hundred Thousand and no/100 Dollars ($300,000.00),
or such lesser amount as may be owing hereunder after giving effect to any prepayments hereof, plus any interest pursuant to Section 1.2 of this Promissory Note. All principal and interest due hereunder shall be due and payable in full in cash
on September 30, 2004 (the “Maturity Date”). 
 Section 1. Interest. 
 1.1 Borrower promises to pay interest on the balance of principal unpaid prior to the Maturity Date (whether by lapse of time, acceleration or
otherwise), at the rate of 9% (nine percent) per annum. Borrower promises to pay interest on the balance of principal remaining from time to time unpaid after the Maturity Date (whether by lapse of time, acceleration or otherwise), at two percent
(2%) over the rate that would otherwise be in effect (such rate being the “Default Rate”). Interest shall be computed on the basis of a year of 360 days for the actual number of days elapsed and shall be payable upon the Maturity
Date. Interest owing after maturity shall be due upon demand. 
 1.2 Interest on this Promissory Note shall begin to accrue on the
date hereof, but shall not be due until the Maturity Date unless permitted by the Subordination Agreement referred to in Section 4, in which case interest shall be payable on the first day of each month. 
 Section 2. Events of Default and Their Effect. Each of the following shall constitute an “Event of Default” under this Promissory Note:

 (a) Default in the payment when due of the principal of or interest on this Promissory Note. 
 (b) An Event of Default exists under and as defined in the SVB Loan Agreement. 
 Section 3. Effect of Event of Default. If any Event of Default occurs, Lender may declare this Promissory Note and all indebtedness, liabilities and obligations evidenced by this Promissory Note to be due
and payable, all without presentment, demand or notice of any kind. 
 Section 4. Miscellaneous. Borrower hereby waives presentment and notice of
dishonor. No delay by Lender in the exercise of any right or remedy shall operate as a waiver thereof, and no single or partial exercise by Lender of any right or remedy shall preclude any other or further exercise thereof or the exercise of 

 
any other right or remedy. It is agreed that this Promissory Note and all the rights and remedies of the holder hereof shall be construed in accordance with
and governed by the laws of Washington. If any part of this Promissory Note is unenforceable, that will not make any other part unenforceable. If this Promissory Note is not dated when executed by Borrower, Lender is hereby authorized without notice
to Borrower to date this Promissory Note as of the date when the loan evidenced hereby is made. 
 The indebtedness evidenced by this
Promissory Note is subordinated to the prior payment in full of the Silicon Debt (as defined in the Subordination Agreement hereinafter referred to) pursuant to, and to the extent provided in, the Subordination dated September 30, 2002 by
Lender in favor of Silicon Valley Bank. This Promissory Note is not subordinated to any other obligations of Borrower. 
 ORAL AGREEMENTS
OR ORAL COMMITMENTS TO LOAN MONEY, EXTEND CREDIT, MODIFY LOAN TERMS, OR TO FORBEAR FROM ENFORCING REPAYMENT OF A DEBT ARE NOT ENFORCEABLE UNDER WASHINGTON LAW. 
  

			
	APPLIED PRECISION HOLDINGS, LLC
	
	 /s/ Bruce Holdren

	 Name:
	 	 Bruce Holdren

	 Title:
	 	 Chief Financial OfficerAmendment to Promissory Note in favor of Ronald C. Seubert

 Exhibit 10.13 
 Applied Precision Holdings, LLC 
 AMENDMENT TO PROMISSORY NOTE 
 December 28, 2004 
 Reference is made to
the Promissory Note (“Note”) granted by Applied Precision Holdings, LLC (“APHLLC”) to Ronald C. Seubert dated March 31, 2003, in the amount of $300,000.00. 
 The Note stated that all principal and interest due under the Note was due and payable in full in cash on September 30, 2004 (the “Maturity
Date”). 
 The parties to the Note hereby agree that the Maturity Date is hereby amended to September 30, 2006. All other terms and
conditions of the Note are unchanged, and shall continue in full force and effect. 
  

			
	 Applied Precision Holdings, LLC

		
	 By:
	 	 /s/ Bruce Holdren

	 Bruce Holdren

	 Chief Financial Officer

	
	
	
	 /s/ Ronald C. Seubert

	 Ronald C. Seubert

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