Document:

EX-10.1

 Exhibit 10.1 

TERMINATION AGREEMENT 

This Termination Agreement (the “Agreement”), is made and entered into as of the latest date of signature below and is
effective as of October 1, 2013 (the “Effective Date”) by and between Brookhaven Science Associates, LLC (“Brookhaven”) and Catalyst Pharmaceutical Partners, Inc. (“Catalyst”). 

WHEREAS, Brookhaven and Catalyst are parties to that certain License Agreement, the effective date of which is April 3, 2006, as
amended to date (collectively, the “License Agreement”); and 
 WHEREAS, Brookhaven and Catalyst have mutually
agreed to terminate the License Agreement, effective as of the Effective Date, and have agreed to the terms set forth below. 
 NOW,
THEREFORE, the parties hereto agree as follows: 
  

	1.	Termination of License Agreement. The License Agreement is hereby terminated as of the Effective Date. As of the Effective Date neither party has any further obligations under the License Agreement.

  

	2.	Mutual General Releases. 

  

	 	A.	Brookhaven, on behalf of itself and each of its legal representatives, administrators, members, managers, officers, directors, agents, employees, attorneys, accountants, successors, and assigns, does hereby release,
relinquish, acquit, waive, and forever discharge Catalyst, along with each of its respective affiliates, officers, directors, agents, employees, representatives, attorneys, accountants, successors and assigns, from any and all claims, counterclaims,
rights, demands, actions, suits, requests, proceedings, liabilities or causes of action, whether known or unknown as of the Effective Date, that Brookhaven may have, directly or indirectly, against Catalyst that arose or will arise out of, in whole
or in part, any act, omission to act, transaction, practice, conduct, matter, cause, or thing of any kind or character that arose or occurred prior to the Effective Date hereof relating to or arising under the License Agreement, including within the
scope of such release any obligations of Catalyst to Brookhaven pursuant to Article III of the License Agreement (relating to “Reimbursement of Licensor’s Patent Costs”). 

 

	 	B.	 Catalyst, on behalf of itself and each of its legal representatives, administrators, officers, directors, agents, employees, attorneys, accountants,
successors, and assigns, does hereby release, relinquish, acquit, waive, and forever discharge Brookhaven, along with each of its respective affiliates, members, managers, officers, directors, agents, employees, representatives, attorneys,
accountants, successors and assigns, from any and all claims, counterclaims, rights, demands, actions, suits, requests, proceedings, liabilities or causes of action, whether known or unknown as of the Effective Date, that Catalyst may have, directly
or indirectly, against Brookhaven that arose or will arise out of, in whole or in part, 

  

	 	
any act, omission to act, transaction, practice, conduct, matter, cause, or thing of any kind or character that arose or occurred prior to the Effective Date hereof relating to or arising under
the License Agreement, including within the scope of such release any obligations of Brookhaven to Catalyst pursuant to “Article VI – Auditing,” paragraph (b) of the License Agreement. 

 

	3.	Confidentiality. Unless required by applicable law or regulation or requested by any regulatory authority, no party shall disclose any non-public information provided by the other party in connection with the
License Agreement without the prior written consent of the other party, and if such disclosure is so required by law or regulation or requested by a regulatory authority, the party required to disclose shall, to the extent permitted by law or
advised by counsel, use commercially reasonable efforts to afford the other party a reasonable opportunity to review and comment upon any such disclosure prior to the making of such disclosure. The foregoing shall not prohibit Catalyst from
disclosing the existence of this Agreement in its filings with the U.S. Securities and Exchange Commission (“SEC”) and attaching a copy of this Agreement as an exhibit to its filings with the SEC. Similarly, Brookhaven shall not be
prohibited from disclosing the existence of this Agreement and permitting the U.S. Department of Energy, upon request, to have access to this Agreement. 

  

	4.	Entire Agreement. This Agreement constitutes the entire agreement and understanding between the parties with respect to the subject matter hereof and supersedes and revokes all prior agreements, oral or written.
Each party to this Agreement represents and warrants to the other party that they have the full power and authority to enter into this Agreement and that this Agreement has been approved by all necessary entity action. 

 

	5.	Counterparts. This Agreement may be executed in as many counterparts as may be deemed necessary or convenient, all of which taken together shall constitute one and the same instrument, and any of the
parties hereto may execute this Agreement by signing any such counterpart. 

 [Signatures on Next Page] 

  
 2 

 IN WITNESS WHEREOF, the parties have caused this Agreement to be signed by a duly
authorized representative of such party as of the Effective Date. 
 LICENSOR: 

BROOKHAVEN SCIENCE ASSOCIATES, LLC 
  

			
	By:	 	 /s/ Connie M. Cleary

		 	Connie M. Cleary
	Title	 	Commercialization Manager
	Date:	 	11/8/13

 LICENSEE: 
 CATALYST
PHARMACEUTICAL PARTNERS, INC. 
  

			
	By:	 	 /s/ Patrick J. McEnany

		 	Patrick J. McEnany
	Title:	 	President and CEO
	Date:	 	11/8/13

  
 3EX-10.1

 Exhibit 10.1 

AMENDMENT NO. 5 
 TO

 MARINA VILLAGE OFFICE TECH LEASE 

THIS AMENDMENT NO. 5 TO MARINA VILLAGE OFFICE TECH LEASE (this “Fifth Amendment”) is made and entered into as of
May 31, 2013 (the “Effective Date”), by and between LEGACY PARTNERS I ALAMEDA, a Delaware limited liability company (“Landlord”), and INSITE VISION INCORPORATED, a Delaware corporation
(“Tenant”). 
 R  E  C  I  T  A  L
 S : 
 A. Reference is hereby made to that certain Marina Village Industrial Gross Office Tech Lease dated as of
September 1, 1996 (the “Original Lease”) between Alameda Real Estate Investments, a California limited partnership (“Alameda”) and Tenant, as amended by that certain: (i) Amendment No. 1 to Marina
Village Office Tech Lease dated July 20, 2001 (the “First Amendment”) between Alameda and Tenant; (ii) Amendment No. 2 to Marina Village Office Tech Lease dated August 1, 2003 (the “Second
Amendment”) between Alameda and Tenant; (iii) Amendment No. 3 to Marina Village Office Tech Lease dated November 21, 2006 (the “Third Amendment”) between Landlord (successor-in-interest to Alameda) and
Tenant; and (iv) Amendment No. 4 to Marina Village Office Tech Lease dated April 1, 2007 (the “Fourth Amendment”) between Landlord and Tenant. 

B. The Original Lease, as so amended, shall be referred to herein as the “Lease”. 

C. Pursuant to the Lease, Tenant is currently leasing from Landlord the following (collectively, the “Existing Premises”):
(i) that certain premises commonly known as Suites 100, 103 and 104, containing approximately 20,254 rentable square feet of space (collectively, the “Challenger Premises”) comprising the entire rentable area of that
certain building addressed as 2020 Challenger Drive, Alameda, California (the “Challenger Building”); and (ii) that certain premises commonly known as Suite 100, containing approximately 18,869 rentable square feet of
space (the “Existing Atlantic Premises”) located in that certain building addressed as 965 Atlantic Avenue, Alameda, California (the “Atlantic Building”). The Challenger Building and the Atlantic Building are
sometimes collectively referred to herein as the “Building.” The Existing Premises are part of a multi-building commercial project known as “Marina Village” and located on an approximately 200-acre site on the estuary side
of the island of Alameda (the “Project”). 
 D. Landlord and Tenant now desire to amend the Lease to (i) extend
the Extended Term (as defined in the Third Amendment) for the Existing Premises, (ii) expand the Existing Premises to include the certain premises (the “Atlantic Expansion Space”) containing approximately 5,042 rentable
square feet of space within the Atlantic Building and comprising the balance of the rentable area of the Atlantic Building, as depicted on the floor plan attached hereto as Exhibit A, and (iii) modify various terms and
provisions of the Lease, all as hereinafter provided. 

  
 -1- 

 E. All capitalized terms when used herein shall have the same meanings given such terms in the
Lease unless expressly superseded by the terms of this Fifth Amendment. 
 NOW THEREFORE, in consideration of the foregoing recitals and the
mutual covenants contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

1. Extension of Extended Term. The Extended Term for the Existing Premises, which is currently scheduled to expire on December 31,
2013, is hereby extended until December 31, 2020, unless sooner terminated as provided in the Lease, as amended by this Fifth Amendment. Notwithstanding the scheduled date for expiration of the Extended Term provided in the previous sentence,
the period from June 1, 2013 (the “Second Extended Term Commencement Date”) through and including December 31, 2020 (the “Second Extended Term Expiration Date”) is sometimes referred to herein as the
“Second Extended Term”. All references to the term or the Extended Term in the Original Lease, as amended by this Fifth Amendment, shall mean the term of the Lease, as previously extended, or the Extended Term, in each case as
further extended by this Fifth Amendment, including by the Option Term (as defined below), if Tenant properly and timely exercises its Extension Option (as defined below). 

2. Existing Premises Base Rent. 

2.1. Challenger Premises Base Rent. Notwithstanding anything in the Lease, as hereby amended, to the contrary, commencing on
June 1, 2013 and ending on the Second Extended Term Expiration Date, the Base Rent payable by Tenant for the Challenger Premises shall be paid separate and apart from the Base Rent payable for the Existing Atlantic Premises and the Atlantic
Expansion Space, and shall be as set forth in the following schedule: 
  

							
	 Period of

Second Extended Term
	  	 Annual

Base Rent
	  	 Monthly Installment

of Base Rent
	  	 Monthly Base Rental Rate

per Rentable Square Foot of

the Challenger Premises

	 6/1/13-5/31/14
	  	$230,895.60	  	$19,241.30	  	$0.95
	 6/1/14-5/31/15
	  	$243,048.00	  	$20,254.00	  	$1.00
	 6/1/15-5/31/16
	  	$255,200.40	  	$21,266.70	  	$1.05
	 6/1/16-5/31/17
	  	$267,352.80	  	$22,279.40	  	$1.10
	 6/1/17-5/31/18
	  	$279,505.20	  	$23,292.10	  	$1.15
	 6/1/18-5/31/19
	  	$291,657.60	  	$24,304.80	  	$1.20
	 6/1/19-12/31/20
	  	$303,810.00	  	$25,317.50	  	$1.25

  
 -2- 

 2.2. Existing Atlantic Premises Base Rent. Notwithstanding anything in the Lease, as
hereby amended, to the contrary, commencing on June 1, 2013 and ending on the Second Extended Term Expiration Date, the Base Rent payable by Tenant for the Existing Atlantic Premises shall be paid separate and apart from the Base Rent payable
for the Atlantic Expansion Space and the Challenger Premises, and shall be as set forth in the following schedule: 
  

							
	 Period of 
Second Extended

Term
	  	 Annual
Base Rent
	  	 Monthly Installment

of Base Rent
	  	 Monthly Base Rental Rate

per Rentable Square Foot of the

Existing Atlantic

Premises

	 6/1/13-5/31/14
	  	$344,170.56	  	$28,680.88	  	$1.52
	 6/1/14-5/31/15
	  	$355,491.96	  	$29,624.33	  	$1.57
	 6/1/15-5/31/16
	  	$366,813.36	  	$30,567.78	  	$1.62
	 6/1/16-5/31/17
	  	$378,134.76	  	$31,511.23	  	$1.67
	 6/1/17-5/31/18
	  	$389,456.16	  	$32,454.68	  	$1.72
	 6/1/18-5/31/19
	  	$400,777.56	  	$33,398.13	  	$1.77
	 6/1/19-12/31/20
	  	$412,098.96	  	$34,341.58	  	$1.82

 3. Addition of Atlantic Expansion Space. Commencing upon the Atlantic Expansion Space Commencement Date
(as defined in Section 4 below), the Existing Premises shall be expanded to include the Atlantic Expansion Space, thereby increasing the size of the Existing Premises to 44,165 rentable square feet (i.e., 18,869 rentable square feet
in the Existing Atlantic Premises + 5,042 rentable square feet in the Atlantic Expansion Space + 20,254 rentable square feet in the Challenger Premises). The Atlantic Expansion Space shall be leased on the same terms and conditions set forth in the
Lease, subject to the modifications set forth in this Fifth Amendment. Effective from and after the Atlantic Expansion Space Commencement Date, (i) the “Premises” shall mean the Existing Premises and the Atlantic Expansion
Space, and (ii) the “Atlantic Premises” shall mean the Existing Atlantic Premises and the Atlantic Expansion Space. 

4. Atlantic Expansion Space Commencement Date. For purposes of this Fifth Amendment, the term “Atlantic Expansion Space
Commencement Date” shall mean the earlier of: (i) the date Tenant commences business operations in the Atlantic Expansion Space (meaning that Tenant is actually operating its business from the Atlantic Expansion Space, rather than
preparing the Atlantic Expansion Space for its business and occupancy, even if such preparation involves having some of Tenant’s personnel in the Atlantic Expansion Space); and (ii) January 1, 2015. The term for the Atlantic Expansion
Space (the “Atlantic Expansion Space Term”) shall commence on the Atlantic Expansion Space Commencement Date and expire coterminously with the Second Extended Term with respect to the Existing Premises on the Second Extended Term
Expiration Date (i.e., December 31, 2020). The date that the Atlantic Expansion Space Commencement Date actually occurs shall be confirmed by the parties in writing in an Amendment No. 6 to Marina Village Office Tech Lease
(“Amendment No. 6”), which Amendment No. 6 shall be in substantially the form of Exhibit C attached hereto. Amendment No. 6 shall be delivered by Landlord to Tenant after the Atlantic Expansion
Space Commencement Date occurs, and Tenant shall execute and return such Amendment No. 6 to Landlord within five (5) business days after Tenant’s receipt thereof; provided, however, that if Amendment No. 6 is not factually
correct, then Tenant shall make such changes as are necessary to make Amendment No. 6 factually correct and shall thereafter execute and return such corrected Amendment No. 6 to Landlord within such five (5) business day period and
thereafter the dates set forth on such corrected Amendment No. 6 shall be conclusive and binding upon 

  
 -3- 

 
Tenant and Landlord, unless Landlord, within five (5) business days following receipt of Tenant’s changes, sends a notice to Tenant rejecting Tenant’s changes, whereupon this
procedure shall be repeated until the parties mutually agree upon the contents of Amendment No. 6. Failure of Tenant to execute and deliver to Landlord within such 5-business day period Amendment No. 6 submitted by Landlord or failure of
Landlord to reject Tenant’s changes thereto within such 5-business day period, as applicable, shall constitute an acknowledgment by Tenant or Landlord (as applicable) that the statements included in Amendment No. 6 so submitted by Landlord
or Tenant (as applicable) are true and correct, without exception, and binding upon Landlord and Tenant. 
 5. Atlantic Expansion Space
Base Rent. During the Atlantic Expansion Space Term, the Base Rent payable by Tenant for the Atlantic Expansion Space shall be calculated separate and apart from the Base Rent payable for the Existing Premises (i.e., the Existing Atlantic
Premises and the Challenger Premises), and shall be as set forth in the following schedule: 
  

							
	 Period of Atlantic

Expansion
Space Term
	  	 Annual

Base Rent
	  	 Monthly

Installment of

Base Rent
	  	 Monthly Base Rental

Rate per Rentable
 Square Foot of
the
 Atlantic Expansion

Space

	 *Atlantic Expansion

Space Commencement 
Date – 5/31/14
	  	$91,966.08	  	$7,663.84	  	$1.52
	 **6/1/14-5/31/15
	  	$94,991.28	  	$7,915.94	  	$1.57
	 6/1/15-5/31/16
	  	$98,016.48	  	$8,168.04	  	$1.62
	 6/1/16-5/31/17
	  	$101,041.68	  	$8,420.14	  	$1.67
	 6/1/17-5/31/18
	  	$104,066.88	  	$8,672.24	  	$1.72
	 6/1/18-5/31/19
	  	$107,092.08	  	$8,924.34	  	$1.77
	 6/1/19-12/31/20
	  	$110,117.28	  	$9,176.44	  	$1.82

  

	*	Not applicable if the Atlantic Expansion Space Commencement Date occurs after May 31, 2014. 

	**	If the Atlantic Expansion Space Commencement Date occurs after June 1, 2014, payment of Base Rent at the applicable rental rate shown in the chart above shall commence on the actual Atlantic Expansion Space Commencement
Date. 

  
 -4- 

 6. Tenant’s Percentage Share. Due to the revised number of rentable square feet
contained within the Premises (i.e., the Existing Premises and the Atlantic Expansion Space) as compared to the Existing Premises, from and after the Atlantic Expansion Space Commencement Date, the “Tenant’s Percentage Share”
Section of the Basic Lease Information attached to the Original Lease (last amended by Section 7 of the Third Amendment) shall be deleted in its entirety and replaced with the following: 

 

			
	“Tenant’s Percentage Share:	 	 Atlantic Premises – 23,911 rsf/23,911 rsf = 100%
  

Challenger Premises – 20,254 rsf/20,254 = 100%”

7. Condition of Premises; Landlord’s Work; Refurbishment Allowance. 

7.1. Condition of Premises. Except as provided in Sections 7.2 and 7.3 below, and without limiting Landlord’s obligations
under Paragraphs 7 and 8 of the Original Lease, as amended by this Fifth Amendment, (i) Landlord shall not be obligated to provide or pay for (or contribute any improvement or refurbishment allowance for) any improvements, work or services
related to the improvement, remodeling or refurbishment of the Existing Premises and/or the Atlantic Expansion Space, and (ii) Tenant shall accept (A) the Existing Premises in its “AS IS” condition as of the Effective Date,
and (B) the Atlantic Expansion Space in its “AS IS” condition as of the Effective Date and the Atlantic Expansion Space Commencement Date, except that Landlord shall ensure that the Atlantic Expansion Space is in broom-clean
condition on the date Landlord delivers the Atlantic Expansion Space to Tenant. Notwithstanding the foregoing to the contrary, if (1) as of the Atlantic Expansion Space Commencement Date, the base, shell and core systems and equipment of the
Atlantic Building which serve the Atlantic Expansion Space are not in good order, condition and repair, and (2) Tenant becomes aware thereof and delivers to Landlord written notice (the “Non-Compliance Notice”) of such
base, shell and core systems and equipment not being in such condition described hereinabove on or before the date which is ninety (90) days after the Atlantic Expansion Space Commencement Date (the “Non-Compliance Outside
Date”), then Tenant’s sole remedy shall be that Landlord shall, at Landlord’s sole cost and expense (which shall not be included in Operating Expenses), do that which is necessary to bring such base, shell and core systems
and equipment of the Atlantic Building which serve the Atlantic Expansion Space in good order, condition and repair within a reasonable period of time after Landlord’s receipt of the Non-Compliance Notice. If Tenant fails to deliver the
Non-Compliance Notice to Landlord on or prior to the Non-Compliance Outside Date, Landlord shall have no obligation to perform the work described hereinabove (but such release of such obligation shall not relieve Landlord of its other repair
obligations under the Lease, as hereby amended, including, without limitation, Paragraph 8(b) of the Original Lease, as added by Section 9.4(a) below). 

7.2. Landlord’s Work. In a good workmanlike manner and in accordance with all applicable laws, Landlord shall, at Landlord’s
sole cost and expense, perform the following work using Building standard materials (collectively, “Landlord’s Work”): (i) with respect to the Atlantic Building, (A) modify the existing handicap access ramp on the
exterior of the Atlantic Building as and to the extent necessary to correct any existing non-compliance of the ramp with applicable laws in effect as of the date of execution and delivery of this Fifth Amendment, (B) seal the cracks on the
façade of the Atlantic Building at the entrance thereof to the extent existing as of the date of execution and delivery of this Fifth Amendment, (C) install a seismic actuated gas shutoff valve at the gas mains into the Atlantic
Building, and (D) add a flexible pipe section to the fire sprinkler line outside the Atlantic Building for seismic concerns, similar to the sections added to other buildings in the Project including the Challenger Building; and (ii) with
respect to the Challenger Building, install a seismic actuated gas shutoff valve at the gas mains into the Challenger Building. Tenant acknowledges that Landlord will be performing Landlord’s Work during Tenant’s occupancy of the Existing
Premises under the Lease, as hereby 

  
 -5- 

 
amended (and may be performing Landlord’s Work during Tenant’s occupancy of the Atlantic Expansion Space), and Tenant agrees that: (1) Tenant shall reasonably cooperate with
Landlord and Landlord’s schedule of performance of Landlord’s Work during such occupancy so that Landlord may timely perform Landlord’s Work without unreasonable interference from Tenant (and in connection therewith, Landlord may
cause Landlord’s Work to be performed during normal business hours as reasonably necessary to complete the same in a timely manner, without any obligation to pay overtime or other premiums); and (2) Tenant shall accept all reasonable
inconveniences associated with the performance of Landlord’s Work and agrees that the performance of Landlord’s Work shall not constitute a constructive eviction of Tenant, nor entitle Tenant to any Rent abatement compensation (except as
otherwise provided in Paragraph 7(d) of the Original Lease, as added by Section 9.3 below) or other damages from Landlord, nor subject Landlord to any liability, except for any injury to persons or damage to property (but not loss of
business or other consequential damages) to the extent caused by Landlord’s negligence or willful misconduct and not insured or required to be insured by Tenant under the Lease, as hereby amended; provided, however, Landlord agrees to use
commercially reasonable efforts to minimize unreasonable interference with Tenant’s use of and access to the Existing Premises (and following the Atlantic Expansion Space Commencement Date, the Atlantic Expansion Space, as the case may be) as a
result of such Landlord’s Work. 
 7.3. Refurbishment Allowance. 

(a) Refurbishment Allowance. Notwithstanding Section 7.1 above to the contrary, provided Tenant is not then in
default under the Lease, as hereby amended, after expiration of all applicable notice and cure periods, Tenant shall be entitled to receive from Landlord a Refurbishment Allowance (as defined below) to help Tenant pay for the out-of-pocket costs
actually incurred by Tenant during the applicable Refurbishment Allowance Availability Period (as defined below) for the design, permitting and construction of alterations to and refurbishment of the improvements in the Existing Premises and/or the
Atlantic Expansion Space, which are made by or on behalf of Tenant during the applicable Refurbishment Allowance Availability Period and are permanently affixed to the Existing Premises and/or the Atlantic Expansion Space, including, without
limitation, those certain alterations described in the “Scope of Work” attached hereto as Exhibit D (collectively, the “Refurbishment Work”). As used herein, the “Refurbishment
Allowance” shall mean an amount up to, but not exceeding, (i) $1,104,125.00 (i.e., $25.00 per rentable square foot of the entire Existing Premises and the Atlantic Expansion Space) during the period from February 1,
2013 through and including May 31, 2014, and (ii) $220,825.00 (i.e., $5.00 per rentable square foot of the entire Existing Premises and the Atlantic Expansion Space) during the period from February 1, 2013 through and including
November 30, 2015 (each period set forth in clauses (i) and (ii) hereinabove shall be referred to as a “Refurbishment Allowance Availability Period”). The construction and installation of the Refurbishment Work by
Tenant shall be made in accordance with the terms of Paragraph 8(c) of the Original Lease (as amended by Paragraph 5 of the Addendum attached to the Original Lease), except that: 

(i) all Refurbishment Work shall be subject to the mutual approval of the parties, including the mutual approval of all space
plans, working 

  
 -6- 

 
drawings and specifications therefor (collectively, the “Refurbishment Plans”) prepared by architects and engineers selected by Tenant (and reasonably approved by Landlord), at
Tenant’s cost (which cost may be paid out of the Refurbishment Allowance); 
 (ii) Landlord has established
specifications (the “Specifications”) for the Building standard components to be used in the construction of the Refurbishment Work (a copy of which Specifications are attached hereto as Exhibit B), and
unless otherwise agreed to by Landlord, the Refurbishment Work shall comply with the Specifications; 
 (iii) the
Refurbishment Work shall be performed by a general contractor selected by Tenant (the “Contractor”) pursuant to the following procedures: (A) Tenant will put the Refurbishment Plans out for competitive bid to at least
three (3) licensed, bonded and insured general contractors designated by Tenant and approved by Landlord (one of which general contractors shall be Legacy Partners CDS, Inc., an affiliate of Landlord); (B) Tenant shall provide Landlord
with copies of all of such bids of the bidding general contractors (which shall contain all major trade subcontractors’ bids incorporated therein), and a reconciliation shall be performed by Tenant to adjust inconsistent or incorrect
assumptions so that a like-kind comparison can be made and the low bidder for the general contractor determined; and (C) Tenant shall select the Contractor from such bidding general contractors taking into account the following factors:
(1) the bidding general contractor which provides the lowest bid; (2) the bidding general contractor’s experience and reputation in constructing systems and improvements for laboratory and office space; and (3) the quality of the
proposed improvements and systems in such bidding general contractors’ bid; provided, however, if Tenant selects as the Contractor a bidding general contractor which is other than the bidding general contractor providing the lowest bid, then
Landlord shall have the right to approve such Contractor, provided Landlord’s approval shall not be unreasonably withheld or delayed; and 

(iv) Tenant shall not be required to remove any Refurbishment Work described in the “Scope of Work” attached hereto
as Exhibit D upon the expiration or earlier termination of the Lease, as hereby amended. 
 (b)
Disbursement of Refurbishment Allowance. Landlord shall disburse the Refurbishment Allowance to help Tenant pay for the costs of the design, construction, acquisition and installation of the Refurbishment Work actually incurred by Tenant
(collectively, the “Refurbishment Costs”) during the applicable Refurbishment Allowance Availability Period, which Refurbishment Costs shall include a construction supervision and management fee payable to Landlord in an amount
equal to three and one-half percent (3.5%) of the total Refurbishment Costs (the “CM Fee”); provided, however, no CM Fee shall be charged by Landlord as part of the Refurbishment Costs or otherwise if Legacy Partners CDS,
Inc. is retained as the Contractor. Disbursements from the Refurbishment Allowance shall be made pursuant to this Section 7.3(b) on a progress payment basis as the Refurbishment Costs are incurred for the Refurbishment

  
 -7- 

 
Work (in all events prior to the expiration of the applicable Refurbishment Allowance Availability Period, subject to the limitations set forth hereinbelow), and after Landlord has received all
of the following (collectively, the “Refurbishment Work Draw Documents”): (i) a request for payment of Tenant’s Contractor, in a commercially reasonable form, describing the portion of the Refurbishment Work which is the
subject of such request for payment, and setting forth the amount of the Refurbishment Costs incurred in connection with the portion of the Refurbishment Work which is the subject of such request for payment; (ii) invoices which are, to
Tenant’s knowledge, factually correct from all of Tenant’s Agents (as defined below) for labor and materials rendered in connection with such portion of the Refurbishment Work and included for payment in the applicable request for payment;
and (iii) conditional executed mechanics’ lien waivers and releases from the Contractor and all subcontractors and other persons or entities performing such portion of the Refurbishment Work (collectively, “Tenant’s
Agents”) which shall comply with the appropriate provisions of California Civil Code Section 8132 through 8138. Within thirty (30) days after Landlord’s receipt of the Refurbishment Work Draw Documents, Landlord shall deliver
a check to Tenant made jointly payable to the Contractor and Tenant in payment of the lesser of (A) the amounts so requested by Tenant in the applicable Refurbishment Work Draw Documents, less a ten percent (10%) retention (the aggregate
amount of such retentions to be known as the “Final Retention”), and (B) the balance of any remaining available portion of the Refurbishment Allowance (not including the Final Retention). If the CM Fee is applicable, then
Landlord shall deduct the CM Fee from the Final Retention. Subject to the provisions of this Section 7.3(b), a check for the Final Retention (less the CM Fee, if applicable) payable jointly to Tenant and Contractor shall be delivered by
Landlord to Tenant following the completion of all of the Refurbishment Work, as evidenced by Tenant’s delivery to Landlord of properly executed mechanics lien releases in compliance with both California Civil Code Section 8134 and either
Section 8136 or Section 8138. In no event shall Landlord be obligated to make disbursements pursuant to this Section 7.3: (1) more often than once per month; (2) in a total amount which exceeds the Refurbishment Allowance;
(3) before the commencement of the applicable Refurbishment Allowance Availability Period; (4) with respect to any Refurbishment Work Draw Documents delivered before or after the applicable Refurbishment Allowance Availability Period; and
(5) notwithstanding anything to the contrary in this Section 7.3, if as of (x) May 31, 2014 (i.e., the expiration of the Refurbishment Allowance Availability Period pertaining to the portion of the Refurbishment Allowance
totaling $1,104,125.00), all or any portion of such $1,104,125.00 amount is unused, such unused portion shall revert to Landlord and Tenant shall not be entitled to receive such unused portion of the Refurbishment Allowance), and (y) November
30, 2015 (i.e., the expiration of the Refurbishment Allowance Availability Period pertaining to the portion of the Refurbishment Allowance totaling $220,825.00), all or any portion of such $220,825.00 amount is unused, such unused portion
shall revert to Landlord and Tenant shall not be entitled to receive such unused portion of the Refurbishment Allowance). In addition, Tenant shall not be entitled to receive in cash or as a credit against any rental or otherwise, any portion of the
Refurbishment Allowance not used to pay for the Refurbishment Costs. 

  
 -8- 

 8. Option to Extend Second Extended Term. Section 10 of the Third Amendment is hereby
deleted in its entirety and in lieu thereof, Landlord hereby grants to Tenant one (1) option (the “Extension Option”) to extend the term of the Lease (as hereby amended) for all, but not less than all, of the entire Premises
(i.e., the Existing Premises and the Atlantic Expansion Space) (the “Renewal Premises”) for a period of five (5) years (“Option Term”) immediately following the expiration of the Second Extended Term and
the Atlantic Expansion Space Term (i.e., the Option Term shall be for the period commencing on January 1, 2021 and ending on December 31, 2025), which Extension Option shall be exercisable only by written Exercise Notice (as defined
below) delivered by Tenant to Landlord as provided below. 
 8.1. Option Rent. The annual Base Rent payable by Tenant during the
Option Term (the “Option Rent”): (i) with respect to the Challenger Premises shall be equal to the greater of (A) the Challenger Floor Base Rent (as defined hereinbelow), and (B) the Challenger Fair Market Rental Rate
(as defined hereinbelow); and (ii) with respect to the Atlantic Premises shall be equal to the greater of (A) the Atlantic Floor Base Rent (as defined hereinbelow), and (B) the Atlantic Fair Market Rental Rate (as defined
hereinbelow). As used herein, (1) the “Challenger Floor Base Rent” shall mean an amount equal to the product of (x) $1.25, multiplied by (y) twelve (12), multiplied by (z) the number of rentable square feet
in the Challenger Premises, which Challenger Floor Base Rent will be increased as of the first (1st) anniversary of the commencement date of the Option Term and each annual anniversary
thereafter during the Option Term by three percent (3%) on a cumulative and compounded basis, and (2) the “Atlantic Floor Base Rent” shall mean an amount equal to the product of (x) $1.82, multiplied by
(y) twelve (12), multiplied by (z) the number of rentable square feet in the Atlantic Premises, which Atlantic Floor Base Rent will be increased as of the
first (1st) anniversary of the commencement date of the Option Term and each annual anniversary thereafter during the Option Term by three percent (3%) on a cumulative and
compounded basis. As used herein, the “Challenger Fair Market Rental Rate” shall mean the annual base rent at which non-equity tenants, as of the commencement of the Option Term, will be leasing non-sublease space comparable in
size, location and quality to the Challenger Premises for a comparable term, which comparable space is located in the other existing buildings in the Project which are office buildings, and in other single story office buildings in the Alameda
Office Market that are of age and quality comparable to the Building (collectively, “Comparable Buildings”), taking into consideration all free rent and other out-of-pocket concessions generally being granted at such time for such
comparable space for the Option Term (including, without limitation, any tenant improvement allowance provided for such comparable space, with the amount of such tenant improvement allowance to be provided for the Challenger Premises during the
Option Term to be determined after taking into account the age, quality and layout of the tenant improvements in the Challenger Premises as of the commencement of the Option Term); provided, however, if Tenant does not deliver the Tangible Net Worth
Documentation to Landlord with Tenant’s Interest Notice (as those terms are defined below), or if Landlord is not satisfied with Tenant’s Tangible Net Worth evidenced by the Tangible Net Worth Documentation delivered to Landlord, then the
Challenger Fair Market Rental Rate shall mean the annual base rent at which non-equity tenants, as of the commencement of the Option Term, will be leasing non-sublease space comparable in size, location and quality to the Challenger Premises on an
“as-is” basis for a comparable term, which comparable space is located in the Comparable Buildings (specifically excluding any free rent, tenant improvements, tenant improvement allowance or other rental concessions provided for such
comparable space), and Landlord shall not be required to provide 

  
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any free rent, tenant improvements, tenant improvement allowance or other rental concessions for the Option Term. As used herein, the “Atlantic Fair Market Rental Rate” shall
mean the annual base rent at which non-equity tenants, as of the commencement of the Option Term, will be leasing non-sublease space comparable in size, location and quality to the Atlantic Premises for a comparable term, which comparable space is
located in the Comparable Buildings, taking into consideration all free rent and other out-of-pocket concessions generally being granted at such time for such comparable space for the Option Term (including, without limitation, any tenant
improvement allowance provided for such comparable space, with the amount of such tenant improvement allowance to be provided for the Atlantic Premises during the Option Term to be determined after taking into account the age, quality and layout of
the tenant improvements in the Atlantic Premises as of the commencement of the Option Term); provided, however, if Tenant does not deliver the Tangible Net Worth Documentation to Landlord with Tenant’s Interest Notice, or if Landlord is not
satisfied with Tenant’s Tangible Net Worth evidenced by the Tangible Net Worth Documentation delivered to Landlord, then the Atlantic Fair Market Rental Rate shall mean the annual base rent at which non-equity tenants, as of the commencement of
the Option Term, will be leasing non-sublease space comparable in size, location and quality to the Atlantic Premises on an “as-is” basis for a comparable term, which comparable space is located in the Comparable Buildings (specifically
excluding any free rent, tenant improvements, tenant improvement allowance or other rental concessions provided for such comparable space), and Landlord shall not be required to provide any free rent, tenant improvements, tenant improvement
allowance or other rental concessions for the Option Term. All other terms and conditions of the Lease, as hereby amended, shall apply throughout the Option Term; however, Tenant shall have no extension or renewal option beyond the Extension Option
described in this Section 8. 
 8.2. Exercise of Option. The Extension Option shall be exercised by Tenant, if at all, only in
the following manner: (i) Tenant shall deliver written notice (“Interest Notice”) to Landlord not before October 1, 2019 and not later than December 31, 2019 stating that Tenant may be interested in exercising
the Extension Option, and together with the Interest Notice, Tenant may deliver evidence (collectively, the “Tangible Net Worth Documentation”) to Landlord of Tenant’s then-current tangible net worth and net income, in
the aggregate, computed in accordance with generally accepted accounting principles, but excluding goodwill as an asset (collectively, “Tangible Net Worth”); (ii) Landlord, after receipt of Tenant’s Interest Notice,
shall deliver written notice (the “Option Rent Notice”) to Tenant on or prior to January 31, 2020 setting forth Landlord’s determination of the Option Rent; and (iii) subject to Tenant’s right to object to
the Challenger Fair Market Rental Rate and the Atlantic Fair Market Rental Rate as set forth in the next sentence, if Tenant wishes to exercise the Extension Option, Tenant shall, on or before March 31, 2020 (the “Exercise
Date”), exercise the Extension Option by delivering written notice (“Exercise Notice”) thereof to Landlord. If Landlord determines in Landlord’s Option Rent Notice that the Option Rent for the Challenger
Premises for the Option Term shall equal the Challenger Fair Market Rental Rate pursuant to Section 8.1(i)(B) above, and/or that the Option Rent for the Atlantic Premises for the Option Term shall equal the Atlantic Fair Market Rental Rate
pursuant to Section 8.1(ii)(B) above, then concurrently with Tenant’s delivery of the Exercise Notice, Tenant may object, in writing, to Landlord’s determination of the Challenger Fair Market Rental Rate and/or the Atlantic Fair
Market Rental Rate, as the case may be, for the Option Term set forth in the Option Rent Notice, in which event such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, shall be determined

  
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pursuant to Section 8.3 below. Tenant’s failure to deliver the Interest Notice or Exercise Notice on or before the applicable delivery dates therefor specified hereinabove shall be
deemed to constitute Tenant’s waiver of the Extension Option. If Tenant timely delivers the Exercise Notice and does not affirmatively state therein that Tenant accepts Landlord’s determination of the Challenger Fair Market Rental Rate
and/or the Atlantic Fair Market Rental Rate, as the case may be, set forth in the Option Rent Notice, then Tenant shall be deemed to have objected to Landlord’s determination of such Challenger Fair Market Rental Rate and/or Atlantic Fair
Market Rental Rate, as the case may be, in which event such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, shall be determined pursuant to Section 8.3 below. If Landlord determines in
Landlord’s Option Rent Notice that the Option Rent for the Challenger Premises shall equal the Challenger Floor Base Rent pursuant to Section 8.1(i)(A) above and/or that the Option Rent for the Atlantic Premises shall equal the Atlantic
Floor Base Rent pursuant to Section 8.1(ii)(A) above, as the case may be, such determination shall be final and conclusive, and the following provisions of Section 8.3 shall not apply with respect to such applicable determination. 

8.3. Determination of Option Rent. If Landlord determines in Landlord’s Option Rent Notice that the Option Rent for the Challenger
Premises for the Option Term shall equal the Challenger Fair Market Rental Rate pursuant to Section 8.1(i)(B) above and/or that the Option Rent for the Atlantic Premises for the Option Term shall equal the Atlantic Fair Market Rental Rate
pursuant to Section 8.1(ii)(B) above, as the case may be, and Tenant timely and appropriately objects in writing pursuant to Section 8.2 above with respect to such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate,
as the case may be, for the Option Term, then Landlord and Tenant shall attempt to agree upon such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, using their good-faith efforts. If Landlord and Tenant
fail to reach agreement by the date (the “Outside Agreement Date”) which is twenty (20) days following Tenant’s delivery of the Exercise Notice, then Tenant shall have the right, within two (2) business days after the
Outside Agreement Date, to rescind the Exercise Notice for the Option Term by delivering written notice of such rescission (the “Rescission Notice”) to Landlord. If Tenant timely and properly delivers to Landlord the Rescission
Notice for the Option Term pursuant to the foregoing, then (i) Tenant shall be deemed to have rescinded the Exercise Notice for the Option Term, (ii) the Extension Option shall be null and void as of the date Tenant delivered such
Rescission Notice to Landlord, and (iii) Landlord and Tenant shall have no further liability to the other under this Section 8. Tenant’s failure to timely deliver the Rescission Notice shall be deemed to be Tenant’s election to
proceed with the exercise of Tenant’s Extension Option for the Option Term and to have the Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, determined pursuant to the following provisions of this
Section 8.3. If Tenant does not timely deliver the Rescission Notice, then each party shall submit to the other party a separate written determination of such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the
case may be, within ten (10) business days after the Outside Agreement Date, and such determinations shall be submitted to arbitration in accordance with the provisions of Sections 8.3(a) through (h) below. The failure of Tenant or
Landlord to submit a written determination of such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, within such ten (10) business day period shall conclusively be deemed to be such party’s
approval of such Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, submitted within such ten (10) business day period by the other party. 

  
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 (a) Landlord and Tenant shall each appoint one (1) arbitrator who shall by profession be a
real estate leasing broker who shall have (i) been active over the ten (10) year period ending on the date of such appointment in the leasing of the Comparable Buildings, (ii) no financial interest in Landlord or Tenant, and
(iii) not represented or employed or engaged the appointing party during such 10-year period. The determination of the arbitrators shall be limited solely to the issue of whether Landlord’s or Tenant’s submitted Challenger Fair Market
Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, is the closer to the actual Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, as determined by the arbitrators, taking into
account the requirements with respect thereto set forth in Section 8.1 above. Each such arbitrator shall be appointed within fifteen (15) days after the Outside Agreement Date. 

(b) The two (2) arbitrators so appointed shall, within fifteen (15) days after the date of the appointment of the last appointed
arbitrator, agree upon and appoint a third arbitrator who shall be qualified under the same criteria set forth hereinabove for qualification of the initial two (2) arbitrators. 

(c) The three (3) arbitrators shall, within thirty (30) days after the date of appointment of the third arbitrator, reach a
decision as to which of Landlord’s or Tenant’s submitted Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, as the case may be, is closer to the actual Challenger Fair Market Rental Rate and/or Atlantic Fair Market
Rental Rate, as the case may be, and shall select such closer determination as the Challenger Fair Market Rental Rate and/or Atlantic Fair Market Rental Rate, respectively, and notify Landlord and Tenant thereof. 

(d) The decision of the majority of the three (3) arbitrators shall be binding upon Landlord and Tenant. 

(e) If either Landlord or Tenant fails to appoint an arbitrator within the time period specified in Section 8.3(a) above, the arbitrator
appointed by one of them shall reach the decision set forth in Section 8.3(c) above, notify Landlord and Tenant thereof, and such arbitrator’s decision shall be binding upon Landlord and Tenant. 

(f) If the two (2) arbitrators fail to agree upon and appoint a third arbitrator, a third arbitrator shall be appointed by the Superior
Court in and for the county of Alameda, California. 
 (g) Each party shall pay the fees and expenses of the arbitrator appointed by or on
behalf of it, and each shall pay one-half of the fees and expenses of the third arbitrator, if any. 
 (h) In no event shall the applicable
Option Rent selected by the arbitrator(s) pursuant to this Section 8.3 be less than the Challenger Floor Base Rent with respect to the Challenger Premises or the Atlantic Floor Base Rent with respect to the Atlantic Premises, as the case may
be. 

  
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 8.4. Default; Rights Personal. Notwithstanding the foregoing, at Landlord’s option,
in addition to any other remedies available to Landlord under the Lease (as hereby amended), at law or in equity, the Extension Option shall not be deemed properly exercised if as of the date of delivery of the Exercise Notice by Tenant Tenant is in
monetary or material non-monetary default under the Lease (as hereby amended) beyond all applicable notice and cure periods. Tenant’s Extension Option is personal to the original Tenant executing this Fifth Amendment (the “Original
Tenant”) and any entity or person to which the Original Tenant’s entire interest in the Lease, as hereby amended, has been assigned pursuant to Section 12(j) of the Original Lease (each, an “Affiliate”) and may
not be assigned or exercised, voluntarily or involuntarily, by or to, any person or entity other than the Original Tenant or such Affiliate assignee, as the case may be, and shall only be available to and exercisable by the Original Tenant or such
Affiliate assignee, as the case may be, when the Original Tenant or such Affiliate assignee, as the case may be, is in actual and physical possession of the entire Renewal Premises. 

9. Single-Tenant Building Modifications. As of (i) the Effective Date, Tenant leases the entire rentable square footage of the
Challenger Building and is the sole tenant of the Challenger Building, and (ii) the Atlantic Expansion Space Commencement Date, Tenant shall lease the entire rentable square footage of the Atlantic Building and shall be the sole tenant in the
Atlantic Building. Accordingly, the following modifications shall be made to the Lease (A) with respect to the Challenger Premises, effective from and after the Effective Date, and (B) with respect to the Atlantic Premises, effective from
and after the Atlantic Expansion Space Commencement Date, and in connection therewith, during the period (1) from the Effective Date through and including the day before the Atlantic Expansion Space Commencement Date, all references in
Sections 9.1 through 9.6 below to the “Premises” shall mean the Challenger Premises, only, and the “Building” shall mean the Challenger Building, only, and (2) from and after the Atlantic Expansion Space Commencement
Date, all references in Sections 9.1 through 9.6 below to the “Premises” shall mean both the Challenger Premises and the Atlantic Premises, and the “Building” shall mean both the Challenger Building and the Atlantic Building
(provided, however, paragraph Section 8(e) of the Original Lease [as added by Section 9.4(b) below] shall apply with respect to both the Challenger Building and the Atlantic Building from and after the Effective Date): 

9.1. Gross-Up Provision. The fourth (4th) sentence of Paragraph 4(a) of
the Original Lease (as replaced by Section 2 of the First Amendment), which provides for an adjustment of Operating Expenses to assume 95% occupancy of the Building, shall be deleted. 

9.2. Janitorial Service. Landlord shall not be obligated to provide any janitorial services to the Premises or replace any light bulbs,
lamps, starters and ballasts for lighting fixtures within the Premises. Tenant shall be solely responsible, at Tenant’s sole cost and expense, for (i) performing all janitorial services, trash removal and other cleaning of the Premises,
and (ii) replacement of all light bulbs, lamps, starters and ballasts for lighting fixtures within the Premises, all as appropriate to maintain the Premises in a manner consistent with the age and quality of the Building and Project. Such
services to be provided by Tenant shall be performed by contractors and pursuant to service contracts reasonably approved by Landlord. Landlord shall have the right to inspect the Premises upon reasonable notice to Tenant to confirm compliance with
the terms of the Lease, as hereby amended. 

  
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 9.3. Services. Paragraph 7 of the Original Lease (as amended by Paragraph 4 of
the Addendum attached to the Original Lease) shall be deleted in its entirety and replaced with the following: 
 “7.
Services. 
 a. Tenant’s Responsibility. Tenant shall be solely responsible, at its sole cost and
expense, for the furnishing of all services and utilities to the Premises, including, but not limited to HVAC, electricity, water, telephone, telecommunications, cleaning, pest control, trash removal and security services (as well as maintenance and
repairs of the Premises in accordance with the provisions of Paragraph 8(a) below and providing the janitorial and other services to the Premises as provided in Section 9.2 of that certain Amendment No. 5 to Marina Village Office
Lease dated May 31, 2013 between Landlord and Tenant [the “Fifth Amendment”]). In connection with the foregoing, Tenant hereby agrees that (i) Landlord shall have absolutely no obligation to provide any such or other
services or utilities to the Premises, it being agreed that this Lease is in the nature of a “single-tenant building” lease (although Landlord shall maintain and keep in service the existing utility connections located outside the Building
and connected to the exterior of the Building as necessary for distribution of such utilities to the Premises by Tenant), (ii) Tenant shall contract directly with the applicable utility providers to provide all such utilities to the Premises,
which utilities shall be separately metered, at Tenant’s cost, and (iii) Tenant shall pay for the cost of such utilities consumed at the Premises (and for all services provided to the Premises) directly to the applicable provider thereof.
All such services and utilities for the Premises shall be provided in such a manner so as to maintain the Premises and the Building in a condition consistent with the age and quality of the Building and the Comparable Buildings, and if Tenant fails
to do so, and such failure shall continue for fifteen (15) days after written notice from Landlord (which notice and cure period shall not be required in the event of an emergency), Landlord shall have the right to provide such services and/or
such utilities and any charges or costs reasonably incurred by Landlord in connection therewith shall be deemed additional rent due and payable by Tenant within ten (10) days after receipt by Tenant of a written statement thereof from Landlord.

 b. Overstandard Tenant Use. If Tenant shall use, or desire to use, electricity, water, HVAC or any other utilities
for the Premises in quantities that exceed the capacity of the equipment supplying the same to the Building, then, subject to applicable law, and subject to Landlord’s approval, which shall not be unreasonably withheld, conditioned or delayed,
Tenant shall, at Tenant’s sole cost and expense, install such supplemental equipment as may be reasonably required to provide such excess capacity. 

c. Interruption of Use. Subject to Section 7(d) below, Tenant agrees that Landlord shall not be liable for damages, by abatement of
rent or otherwise, for failure to furnish or delay in furnishing any utilities or services (including telephone and telecommunication services), or for any diminution in the quality or 

  
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quantity thereof, when such failure or delay or diminution is occasioned, in whole or in part, by necessary and/or elective repairs, replacements, or improvements (subject, however, to
Section 7(d)(ii) below), by any strike, lockout or other labor trouble, by inability to secure electricity, gas, water, or other fuel at the Building or Project after reasonable effort to do so, by any accident or casualty whatsoever, by act or
default of Tenant or other parties, or by any other cause; and such failures or delays or diminution shall never be deemed to constitute an eviction or disturbance of Tenant’s use and possession of the Premises or relieve Tenant from paying
rent (except as otherwise provided in Section 7(d) below) or performing any of its obligations under this Lease. Furthermore, Landlord shall not be liable under any circumstances for a loss of, or injury to, property or for injury to, or
interference with, Tenant’s business, including, without limitation, loss of profits, however occurring, through or in connection with or incidental to a failure to furnish any services or utilities to the Premises. 

d. Special Abatement. If Tenant’s use of the Premises (or any portion thereof) is materially and adversely interfered with as a
result of, and Tenant in fact does not use all or a portion of the Premises, as a result of, (i) Landlord’s failure to maintain and keep in service (whether due to Landlord’s negligence, misconduct or otherwise) the existing utility
connections located outside the Building and connected to the exterior of the Building as necessary for distribution to the Premises by Tenant of those utilities that are part of the Tenant provided services and utilities in accordance with
Paragraph 7(a) above, and/or (ii) Landlord’s elective (as opposed to necessary) repairs, replacements or improvements (in each case, an “Abatement Event”), then Tenant shall deliver written notice to Landlord of such
Abatement Event (the “Abatement Event Notice”). If such Abatement Event continues for five (5) consecutive business days after Landlord’s receipt of the Abatement Event Notice (“Eligibility Period”), then Tenant’s
obligation to pay Base Rent and Tenant’s Percentage Share of Operating Expenses and Property Taxes shall be abated or reduced, as the case may be, from and after the Eligibility Period and shall continue during such time that such Abatement
Event continues to so materially and adversely interfere with Tenant’s use of (and as a result thereof Tenant does not use) all or any portion of the Premises, with such abatement to be in the proportion that the rentable square feet of the
portion of the Premises so materially and adversely interfered with (and that Tenant does not use) bears to the total rentable square feet of the Premises. To the extent Tenant shall be entitled to abatement of Base Rent and Tenant’s Percentage
Share of Operating Expenses and Property Taxes because of a damage or destruction pursuant to Paragraph 10 of this Lease (as amended by Paragraph 7 of the Addendum attached to this Lease and Section 9.5 of the Fifth Amendment) or a
taking pursuant to Paragraph 11 of this Lease, then the Eligibility Period shall not be applicable.” 

  
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 9.4. Maintenance, Repairs and Alterations. Paragraph 8 of the Original Lease shall be
modified as follows: 
 (a) Paragraphs 8(a) and 8(b) of the Original Lease (as amended by Paragraph 5 of the
Addendum attached to the Original Lease) shall be deleted in their entirety and replaced with the following: 
 “a.
Tenant’s Repairs. Subject to Landlord’s repair obligations in Section 8(b) below, and except for any damage by casualty which is not Tenant’s obligation to repair pursuant to Paragraph 10 below, Tenant shall, at
Tenant’s own expense, and with contractors reasonably acceptable to Landlord and subject to Tenant’s compliance with the following provisions of this Paragraph 8(a) and the provisions of Paragraph 8(c) below, keep the Building
and every part thereof (except those portions of the Building which are Landlord’s obligation to maintain pursuant to Paragraph 8(b) below), including, without limitation, all tenant improvements, alterations, additions, equipment,
restrooms, fixtures and furnishings therein (including all of the Building’s systems and equipment located within the Building and the HVAC equipment on the roof of the Building, subject, however, to Landlord’s obligations regarding
replacement of such HVAC equipment as expressly provided below in Section 8(e)), all interior walls and wall coverings, doors, windows, glass, plate glass, ceilings, and skylights, in an order, repair and condition consistent with the age and
quality of the Building and the Comparable Buildings. Such repair obligations shall include, without limitation, replacement of items as may be necessary to keep same in the condition required hereinabove (subject to Landlord’s replacement
obligations set forth below in Section 8(e) below with respect to the Building’s HVAC equipment on the roof of the Building), notwithstanding that such replacements may be considered capital expenditures in accordance with accounting
practices, and shall also include repairs of items above the ceiling, repairs of items below the floors (but not the floor slabs), and/or repairs of items within walls, such as, but not limited to, all plumbing and pipes for restrooms, the equipment
providing distribution within the Building of the HVAC from the HVAC equipment on the roof, and the equipment providing distribution within the Building of all electricity and all other utilities required for the Premises (including all electrical
panels in equipment rooms or elsewhere within the Building). Landlord shall have approval rights (in its sole but good faith discretion) with respect to repairs and/or replacements which may: (i) affect the roof and/or the HVAC equipment
thereon; (ii) affect or consist of any of the structural components of the Building; (iii) adversely affect or consist of any of the Building’s systems and equipment; (iv) affect the exterior of the Building or any portion of the
Project located outside of the Building, or can be seen from outside the Building; and/or (v) change the character of the Building as an office/laboratory building (any of such items set forth in clauses (i) through (v) hereinabove
shall sometimes be referred to as the “Landlord’s Approval Items”). Tenant’s repair obligations set forth hereinabove shall include, without limitation, the obligation to promptly and adequately repair all damage to the Building
and replace or repair all damaged or broken fixtures and appurtenances (subject, however, to the provisions of Paragraph 10 below regarding casualty damage to the Building); provided however, that if Tenant fails to commence such repairs within
ten (10) business days after written notice from Landlord and thereafter diligently pursue such repairs to completion, Landlord 

  
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may, but need not, make such repairs and replacements, and Tenant shall pay Landlord the cost thereof, including a five percent (5%) administration fee sufficient to reimburse Landlord
for all overhead, general conditions, fees and other costs or expenses arising from Landlord’s involvement with such repairs and replacements forthwith upon being billed for same. Tenant shall, at its own cost and expense, enter into regularly
scheduled preventive maintenance/service contracts (and with maintenance contractors) reasonably approved by Landlord for the maintenance and service of all of the items listed above in this Paragraph 8(a) which Tenant is obligated to maintain.
Tenant shall deliver to Landlord full and complete copies of all such contracts entered into by Tenant prior to entering into same. Notwithstanding any other provision herein to the contrary, Tenant may continue to use of the laboratory benches,
casework, fume hoods and laminar flow hoods located in the Premises as of the Effective Date at no additional cost throughout the Second Extended Term, as the same may be further extended. 

b. Landlord’s Repairs. Anything contained in Paragraph 8(a) above to the contrary notwithstanding, and subject
to Paragraphs 10 and 11 of this Lease, Landlord shall maintain, as part of Operating Expenses, the following (collectively, “Landlord’s Repair Items”): (i) the common areas of the Project (including those systems and equipment
located outside the Building but serving the Building, but excluding the HVAC equipment located on the roof of the Building, subject, however, to Landlord’s obligations regarding replacement of the HVAC equipment located on the roof of the
Building provided in Section 8(e) below); (ii) the structural portions of the roof (including the roof membrane); (iii) the foundation and floor slabs of the Building; and (iv) the exterior walls and load-bearing portions of
walls (excluding wall coverings, painting, glass and doors) of the Building; provided, however, to the extent such maintenance and repairs are caused by the act, neglect, fault of or omission of any duty by Tenant, its agents, employees,
contractors, subtenants, licensees or invitees, Tenant shall pay directly to Landlord as additional rent (but not as part of Operating Expenses), the reasonable cost of such maintenance and repairs. Landlord shall not be liable for any failure to
make any such repairs, or to perform any maintenance and there shall be no abatement of rent and no liability of Landlord by reason of any injury to or interference with Tenant’s business arising from the making of any repairs, alterations or
improvements in or to any portion of the Project, Building or the Premises or in or to fixtures, appurtenances and equipment therein. Tenant hereby waives and releases its right to make repairs at Landlord’s expense under Sections 1941 and
1942 of the California Civil Code; or under any similar law, statute, or ordinance now or hereafter in effect. 
 In
addition to the foregoing obligations, Landlord shall comply with all applicable laws (including, without limitation, the Americans With Disabilities Act of 1990 or any other applicable state or federal accessibility laws or regulations) relating to
Landlord’s Repair Items. The cost of such compliance (other than the cost to correct any non-compliance of Landlord’s Repair Items with laws that exist as of the Effective Date of the Fifth Amendment [as defined

  
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in the Fifth Amendment]) shall be included in Operating Expenses (provided, however, to the extent the cost of such compliance pertains to a capital improvement, such cost shall be amortized,
including interest on the unamortized cost at a rate equal to Landlord’s cost of funds [the “Interest Rate”] in equal annual installments over the reasonable useful life of the applicable capital improvement as established by the
manufacturer of the applicable capital improvement) Landlord shall provide reasonable evidence to Tenant of its cost of funds.” 

(b) The following shall be added as new Section 8(e) of the Original Lease: 

“(e) HVAC Equipment. Notwithstanding anything in this Section 8 to the contrary, if either party reasonably
determines that the HVAC equipment located on the roof of the Building requires replacement instead of repairs, Landlord and Tenant shall negotiate in good faith to determine whether such replacements (instead of repairs) will be required to be
performed. If repairs rather than replacements are required to be made, all repair costs with respect to the HVAC equipment on the roof of the Building shall be incurred by Tenant, at Tenant’s sole cost and expense; provided, however, if any
required repairs are capital repairs (meaning, the aggregate cost thereof will exceed thirty-three percent (33%) or more of the replacement value of such repair item), then such capital repairs shall be performed by Landlord at Landlord’s
sole cost and expense, provided further, however, (i) the cost of such capital repairs so paid by Landlord shall be amortized (including interest on the unamortized cost at the Interest Rate) in equal annual installments over the useful life of
such repair item in accordance with standard real estate management and accounting practices consistently applied by Landlord, and shall be included in Operating Expenses, and (ii) if any such capital repairs are required due to the negligence
or willful misconduct of Tenant or Tenant’s agents, employees, contractors, subtenants, licensees or invitees (including as a result of Tenant’s failure to perform its maintenance and repair obligations set forth in this Section 8),
then such capital repairs shall be performed by Tenant at Tenant’s sole cost and expense. If it is determined by the parties that replacements of the HVAC equipment on the roof of the Building are required to be performed, such replacements
shall be performed by Landlord at Landlord’s sole cost and expense; provided, however, that (A) the cost of such replacements so paid by Landlord shall be amortized (including interest on the unamortized cost at the Interest Rate) in equal
annual installments over the useful life of such replacement as established by the manufacturer of such replacement, and shall be included in Operating Expenses, and (B) if any such replacements are required due to an act, omission or
negligence of Tenant or Tenant’s agents, employees, contractors, subtenants, licensees or invitees (including as a result of Tenant’s failure to perform its maintenance and repair obligations set forth in this Section 8), then such
replacements shall be performed by Tenant at Tenant’s sole cost and expense.” 

  
 -18- 

 9.5. Physical Damage Insurance on the Building. The following shall be added to the end of
Section 9(a) of the Original Lease (as amended by Paragraph 6 of the Addendum attached to the Original Lease): 
 “In addition
to any property damage insurance Tenant is required to maintain as provided hereinabove, Tenant shall procure Physical Damage Insurance covering all interior portions of the Building, including all improvements, alterations and additions now
existing or hereafter made to the interior of the Building (including, without limitation, any Refurbishment Work [as defined in the Fifth Amendment], but specifically excluding Landlord’s Repair Items, and excluding the HVAC equipment located
on the roof of the Building). Such insurance shall be written on the same basis and shall be maintained in the same manner as the property damage insurance pursuant to and in accordance with the terms and provisions hereinabove. Landlord shall
maintain throughout the Second Extended Term (as the same may be further extended) broad form property damage insurance insuring Landlord’s Repair Items and the HVAC equipment located on the roof of the Building. Any damage that is covered by
Landlord’s insurance (or that would have been covered if Landlord had maintained the insurance required to be maintained by it under this Lease), shall not be charged to Tenant either directly or as an Operating Expense.” 

9.6. Damage or Destruction. Paragraph 10 of the Original Lease (as amended by Paragraph 7 of the Addendum attached to the
Original Lease) shall be amended in the following respects: 
 (a) In the event of a damage to or destruction of the
Building, Landlord shall not be obligated to repair or restore Tenant’s personal property in the Premises. 
 (b) If
the cost of any repair by Landlord of any damage to any portion of the Building which is other than Landlord’s Repair Items exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance carrier, as assigned by
Tenant, the cost of such repairs shall be paid by Tenant to Landlord prior to Landlord’s repair of the damage. Landlord agrees that if the HVAC equipment located on the roof of the Building is damaged as a result of a casualty, Landlord shall
repair and/or replace such damaged HVAC equipment. 
 10. Miscellaneous Modifications. The Lease shall be modified as follows: 

10.1. From and after the Effective Date, with respect to Paragraph 4(a) of the Original Lease (as replaced by Section 2 of the First
Amendment): 
 (a) the following shall be added to the end of clause (1) thereof: “and/or the Project (subject to
the immediately following sentence, as added by Section 10.1(c) of the Fifth Amendment), including, without limitation, (A) the cost of any capital improvements or other costs (I) which are intended as a labor-saving device or to
effect other economies in the operation or maintenance of the Building (but not in 

  
 -19- 

 
excess of the cost savings reasonably anticipated to result to Tenant therefrom), (II) made to the Building and/or the Project (subject to the immediately following sentence, as added by
Section 10.1(c) of the Fifth Amendment) or any portion thereof that are required under any governmental law or regulation first enacted after the Effective Date of the Fifth Amendment, or (III) which are Conservation Costs, as defined below
(but not in excess of the cost savings reasonably anticipated to result to Tenant therefrom); provided, however, that if any such cost described in (I), (II) or (III) above is a capital improvement, such cost shall be amortized (including interest
on the unamortized cost at the Interest Rate) in equal annual installments over the reasonable useful life of the applicable capital improvement as established by the manufacturer of such capital improvement, (B) the costs and expenses of
complying with, or participating in, conservation, recycling, sustainability, energy efficiency, waste reduction or other programs or practices implemented or enacted from time to time at the Building and/or Project, including, without limitation,
in connection with any LEED (Leadership in Energy and Environmental Design) rating or compliance system or program, including that currently coordinated through the U.S. Green Building Council or Energy Star rating and/or compliance system or
program (collectively, “Conservation Costs”) (but not in excess of the cost savings reasonably anticipated to result to Tenant therefrom), and (C) the costs of maintenance, repair, and/or operation of the parking lots, walkways and
landscaping of the Project (subject to the immediately following sentence, as added by Section 10.1(c) of the Fifth Amendment).” 

(b) the following shall be added to the end of clause (2) thereof: “and/or the Project (subject to the immediately
following sentence, as added by Section 10.1(c) of the Fifth Amendment)”; 
 (c) the following shall be added
after the third (3rd) sentence thereof: “Notwithstanding the foregoing to the contrary, certain of the Operating Expenses incurred in connection with the Project shall be reasonably and
equitably shared among the Building and/or the other buildings in the Project.”; and 
 (d) clause (x) thereof
shall be deleted and replaced with: “(x) costs of items considered capital improvements, capital repairs, capital replacements, and/or capital equipment, all as determined in accordance with generally accepted accounting principles,
consistently applied, except for capital repairs, which shall be determined pursuant to Section 8(e) below, as added by Section 9.4(b) of the Fifth Amendment, except as expressly permitted in clause (1) hereinabove.” 

10.2. From and after the Effective Date, the following shall be added as new Section 8(d) of the Original Lease: 

“(d) Removal of Tenant Property by Tenant. Upon the expiration or any earlier termination of this Lease, Tenant shall quit and
surrender possession of the Premises to Landlord in as good order and condition as when Tenant took possession and as thereafter improved by Landlord and/or Tenant, reasonable wear and tear and repairs which are specifically made the responsibility
of Landlord under this Lease excepted. Upon such 

  
 -20- 

 
expiration or termination, Tenant shall, without expense to Landlord, remove or cause to be removed from the Premises all furniture, equipment, free-standing cabinet work, trade fixtures and
other articles of personal property owned by Tenant or installed or placed by Tenant at its expense in the Premises, and all debris and rubbish, and such similar articles of any other persons claiming under Tenant, and Tenant shall repair at its own
expense all damage to the Premises and Building resulting from such removal. Notwithstanding any other provision of this Lease to the contrary, Tenant shall have no obligation to remove any (i) improvements existing in the Premises as of the
Effective Date of the Fifth Amendment, (ii) any Refurbishment Work described in the “Scope of Work” attached hereto as Exhibit D, or (iii) telephone, data and other cabling and wiring (including any cabling and
wiring associated with the Wi-Fi Network, if any) installed or caused to be installed by Tenant in the Premises at any time. Upon the expiration or any earlier termination of this Lease, Tenant shall have the right, but not the obligation (unless
such specialized improvement was previously designated by Landlord to be removed pursuant to Section 8(c) above), to remove from the Premises any specialized improvements paid for and installed by Tenant in the Premises from Tenant’s own
funds so long as Tenant repairs at its own expense all damage to the Premises and Building resulting from such removal.” 
 10.3. From
and after the Effective Date, with respect to Section 16(c) of the Original Lease, the phrase “or sell” shall be added after the word “refinance” therein, and the phrase “lender” set forth two (2) times
therein shall be deleted and replaced with: “lender and/or prospective purchaser, as the case may be”. 
 10.4. From and after the
Effective Date, the following shall be added to the end of the penultimate sentence of Section 17 of the Original Lease: “and Tenant’s right to quiet possession of the premises shall not be disturbed by such purchaser at the
foreclosure sale, grantee under the deed in lieu of foreclosure or ground lessor, as the case may be, so long Tenant is not in default under this Lease and so long as Tenant shall pay the rent and observe and perform all of the provisions of this
Lease, unless this Lease is otherwise terminated pursuant to its terms.” 
 10.5. From and after June 1, 2013, Section 9 of
the Third Amendment shall be deleted in its entirety and of no further force or effect. 
 11. SNDA. Tenant hereby acknowledges that
as of the Effective Date there is a deed of trust encumbering, and in force against, the Building in favor of U.S BANK, N.A AS SUCCESSOR IN INTEREST TO WELLS FARGO BANK, N.A , as Trustee for the registered holders of J.P. MORGAN CHASE COMMERCIAL
MORTGAGE SECURITIES CORP., Commercial Mortgage Pass-Through Certificates, Series 2006-FL2 (the “Current Lender”). Simultaneously with Tenant’s execution of this Fifth Amendment, Landlord, Tenant and Current Lender shall sign,
notarize and deliver a subordination, non-disturbance and attornment agreement substantially in the form of Exhibit E attached hereto (the “Current SNDA”). The 

  
 -21- 

 
fees and costs charged to Landlord by the Lender in connection with the Current SNDA are set forth on Exhibit F attached hereto; Tenant shall pay for $1,123.50 of such costs
and fees within thirty (30) days after the mutual execution and delivery of this Fifth Amendment and Landlord shall pay for $1,500.00 of such costs and fees. 

12. California Accessibility Disclosure. For purposes of Section 1938 of the California Civil Code, Landlord hereby discloses to
Tenant, and Tenant hereby acknowledges, that the Existing Premises and the Atlantic Expansion Space have not undergone inspection by a Certified Access Specialist (CASp). 

13. Brokers. Tenant represents and warrants to Landlord that Tenant has not dealt with any broker in connection with this Fifth
Amendment except for Kidder Matthews, representing Tenant (the “Broker”), and insofar as Tenant knows, no other broker negotiated or participated in the negotiations of this Fifth Amendment or is entitled to any commission in
connection herewith. Landlord shall pay the brokerage commissions owing to the Broker in connection with this Fifth Amendment pursuant to the terms of a separate written agreement between Landlord and the Broker. Each party agrees to indemnify,
defend, protect and hold the other party harmless from and against any and all Claims with respect to any leasing commission or equivalent compensation alleged to be owing on account of the indemnifying party’s dealings with any real estate
broker or agent in connection with this Fifth Amendment other than the Broker. The terms of this Section 11 shall survive the expiration or earlier termination of the Lease (as hereby amended). 

14. Successors and Assigns. Subject to any provisions of the Lease (as hereby amended) restricting assigning or subletting by Tenant
and subject to the provisions for the transfer of Landlord’s interest, the Lease (as hereby amended) shall bind the parties, their successors and assigns. 

15. No Further Modification. Except as set forth in this Fifth Amendment, all of the terms and provisions of the Lease shall remain
unmodified and in full force and effect. 
 16. Counterparts. This Fifth Amendment may be executed in multiple counterparts, each of
which is to be deemed original for all purposes, but all of which together shall constitute one and the same instrument. 
 [SIGNATURES
APPEAR ON THE FOLLOWING PAGE] 

  
 -22- 

 IN WITNESS WHEREOF, the parties have caused this Fifth Amendment to be duly executed by their
duly authorized representatives as of the date first above written. 
  

					
	LANDLORD:	 		 	LEGACY PARTNERS I ALAMEDA, LLC,
		 		 	a Delaware limited liability company,
		 		 	Owner
			
		 		 	 By: Legacy Partners Commercial, L.P.,

      a California limited partnership,

      as Property Manager and Agent for Owner

			
		 		 	      By: Legacy Partners Commercial, Inc.,
		 		 	             its General Partner

  

					
		 		 	
By: /s/ Hanna Eyal                    
                                    

Name: Hanna Eyal
 Its: Senior Vice President

DRE #01178811
 BL DRE #01464134

  
  

							
	TENANT:	 		 	 INSITE VISION INCORPORATED,
 a
Delaware corporation

				
		 		 	By:	 	 /s/ Louis Drapeau

		 		 		 	Name: Louis Drapeau
		 		 		 	Title:  VP, Chief Financial Officer
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  
 -23- 

 EXHIBIT A 

DEPICTION OF ATLANTIC EXPANSION SPACE 

[Attached]. 

  
 EXHIBIT A 

-1- 

 

 
  

  
 EXHIBIT A 

-2- 

 EXHIBIT B 

SPECIFICATIONS 
 PARTITIONS

  

	A.	DEMISING PARTITION AND CORRIDOR WALLS 

  

	 	1.	3-5/8” (or match existing)- 20 gauge metal studs—24” on center maximum from floor to ceiling grid. (Provide backing for cabinet as required). 

 

	 	2.	5/8” Type ‘X’ gypsum wallboard one layer each side of studs, fire taped only. 

  

	 	3.	Height from floor to ceiling grid. 

  

	 	4.	Seismic bracing per code. 

  

	 	5.	Two rows of continuous acoustical sealant—bottom tracks. R-11 batt type fiberglass insulation between studs. 

Note: 
  

	 	•	 	All partitions to be paint finished on smooth surfaces GA-214, level 5 smoothness. 

  

	 	•	 	One hour rated walls where required based on occupancy group. 

  

	 	•	 	All interior 1-hour corridors to be tunnel construction in compliance with UBC requirements for one-hour fire rated assembly. 

  

	B.	TYPICAL INTERIOR PARTITION (Non rated) 

  

	 	1.	3-5/8” (or match existing)—25 gauge metal studs—24” on center maximum. (provide backing for wall mounted cabinetry or equipment as required). 

 

	 	2.	5/8” Type ‘X’ gypsum wallboard one layer each side of studs. 

  

	 	3.	Height from floor to ceiling grid—approximately 9’-0” or 10’-0” based on structure cost at all floors; regular ceiling tiles must be scribed. 

 

	 	4.	Seismic bracing per code. 

  

	 	5.	All exterior corners with corner beads. All exposed edges finished with metal trim. 

 Note:

  

	 	•	 	All partitions to be paint finished on smooth surfaces GA-214, level 5 smoothness. 

  

	 	•	 	Partitions must connect to building mullions or walls. Mechanical fasteners to mullions shall not be allowed. 

  

	C.	PERIMETER DRYWALL (at office areas) 

  

	 	1.	2-1/2”—25 gauge metal studs 24” on center to 6” above suspended ceiling (or as required by Title-24 for full height envelope, refer to demising wall specification. 

 

	 	2.	5/8” Type ‘X’ gypsum wallboard one layer on one side. 

  

	 	3.	Height—floor slab to 6” above ceiling grid. 

  

	 	4.	All exterior corners with corner beads. 

 Note: 

 

	 	•	 	All partitions to be paint finished on smooth surfaces GA-214, level 5 smoothness. 

  

	D.	COLUMN FURRING 

  

	 	1.	5/8” Type ‘X’ gypsum wallboard, one layer on 2 1/2” – 25 gauge metal studs, UNO. 

  
 EXHIBIT B 

-1- 

	 	2.	Height—floor slab to 2” above ceiling grid. 

  

	 	3.	All exterior corners with corner beads. 

 Note: 

 

	 	•	 	All partitions to be paint finished on smooth surfaces GA-214, level 5 smoothness. 

  

	E.	INSULATION 

  

	 	1.	Insulation at all perimeter walls and roof per specifications. 

  

	 	2.	All common area walls including corridor, conference, copy rooms and lunch room to receive R-11 within partition cavity and four feet on either side of partition over ceiling at demising wall (if not full height).

  

	F.	FIRE BLOCKING 

  

	 	1.	2-1/2” 20 Gauge metal studs. 

  

	 	2.	5/8” gypsum wallboard one layer on one side. 

  

	 	3.	Height from top of suspended ceiling to structure above as required by code. 

  

	 	4.	Locate as required by code for the proposed tenant space plans. 

  

	G.	PAINTING 

  

	 	1.	All gypsum board walls to receive a prime coat (hi-build PVA sealer) and two (2) coats to cover of ‘carefree’ eggshell finish paint or equal. 

 

	 	2.	Semi-gloss paint at all kitchens, break rooms, restrooms and server/copy rooms. 

 DOORS, FRAMES AND HARDWARE

 Note: all doors and hardware within existing buildings to match U.O.N. 
  

	A.	INTERIOR TENANT DOOR ASSEMBLY (non-rated doors within office suites) 

  

	 	1.	Interior doors: shall be 3’0” wide x full height x 1  3⁄4“ blind end” flush doors (unless otherwise
specified), solid core, pre-finished with plain sliced select white maple, book-match with clear sealer. All doors shall be 20 minute fire rated. 

  

	 	2.	(existing condition) Doors shall be pre-finished and match existing core doors in finish, material and appearance. Finish all edges. 5” top blocking at doors w/closers. 

 

	 	3.	Interior Tenant doorframes to be prefinished rated Western Integrated frames with factory finish; Color: Satin Aluminum. 

  

	 	4.	Corridor doorframes to Suites to be: Satin Aluminum. 

  

	 	5.	Hardware: 

  

	 	(a)	Interior Tenant Door. 

  

					
	 QTY
	  	 SUBTYPE
	  	 ITEM DESCRIPTION

	 4
	  	Butts (2 pair per door)	  	Hager
	 1
	  	Latchset	  	Schlage “L” Series Mortise
	 1
	  	Lockset	  	Schlage “L” Series Mortise
	 1
	  	Door Stop	  	Glynn Johnson FB13, floor Dome
	 1
	  	Closer	  	LCN #4111 (where required)

  
 EXHIBIT B 

-2- 

	 	(b)	Suite Entry Doors-Fire rated as required by occupancy and code requirements. 

  

					
	 QTY
	  	 SUBTYPE
	 	 ITEM DESCRIPTION

	8	  	Hinges (4 pair per door)	 	Hager
	1	  	Lockset	 	Schlage “L” Mortise
	1	  	Auto Flush Bolt            	 	942 626 DCI
	1	  	Dust Proof Strike	 	80 626 DCI
	2	  	Door Stops	 	Glynn Johnson FB13, floor Dome
	1	  	Closer	 	LCN #4111 (where required)

  

	B.	INTERIOR GLAZING 

  

	 	1.	(a)  1⁄4“ thick clear tempered glass in non-rated, prefinished frames by Western Integrated frames with aluminum trim. Frame
to be factory finished; Color: Satin Aluminum (b) 1⁄4 thick clear tempered glass in non-rated, M-121 glass stops; Color: Satin Aluminum.

  

	 	2.	 1⁄4“ thick tempered safety glass where required per code. 

 

	 	3.	Return gypsum board into opening at both sides, provide metal corner bead all around opening. Finish to match wall. 

  

	 	4.	Provide two 20 Ga. metal studs fastened at 12” O.C. back-to-back at jambs and head (minimum) as per detail. Provide seismic brace per code. 

Note: 
  

	 	•	 	All office doors to have 2’-0” wide by full height (inside window frame to inside window frame) sidelights where possible. At areas where less than 2’-0” is available, provide maximum. Sidelight
frames to be integral with doorframes. 

 SUSPENDED ACOUSTICAL CEILING 

Note: Tenant ceiling height at 9’-0” (installed at top of top exterior window mullion). 

 

	 	1.	Grid: USG Donn Fineline DXFF Narrow 9/16” face with 1/8” reveal. Finish: White Matte with white reveal, Suspension System with wire suspension and seismic bracing per code. Wall angle: M9. 

 

	 	2.	Tile: USG 2’x2’x  3⁄4“ Millennia Tegular White. 

 

	 	3.	Seismic bracing per code. 

  

	 	4.	Seismic wires for lighting and electrical to be provided by acoustical ceiling contractor. 

 WINDOW
COVERINGS 
  

	 	1.	Exterior Window covering – horizontal: 1” mini-blinds as manufactured by Levelor, series: Riviera Dustguard. 

  

	 	2.	Blinds to be sized to fit inside window module. Fasten to top horizontal mullions only. 

  

	 	3.	Vertical blinds to be installed with building shell but costs allocated to tenant improvement allowance. 

FIRE SPRINKLER SYSTEM 
  

	 	1.	A pre-zoned sprinkler will be provided in all areas. Head locations will be determined by a pre-zoned master layout. Modification of sprinkler locations and piping, due to specific tenant layout, will be at
tenant’s cost. Semi-recessed pendent sprinkler heads with white escutcheon. Sprinkler to be centered in tile. 

  

	 	2.	Fire Sprinkler coverage light hazard, .33 gpm / 3,000 SF in shell and modified per improvement. 

  

	 	3.	Gyp Board Ceilings: Fully recessed with cap at gypsum board ceiling. Reliable Model F4FR Concealed automatic sprinkler with
 1⁄2“—1  1⁄2“ adjustment—White.

  
 EXHIBIT B 

-3- 

 SIGNAGE 

Refer to Landlord 
 CABINETRY 

 

	 	1.	6’-0” linear feet of upper and lower millwork allowable by building standard. 

  

	 	2.	Plastic laminate horizontal and vertical surfaces. 

  

	 	3.	Horizontal and Verticals: See individual options under finishes for plastic laminate specifications. 

  

	 	4.	Cabinetry Construction: Designation, APA C-D plugged with exterior glue,  3⁄4“ thick or
 3⁄4“ high pressure particle board. Min. density 45 PSF, U.N.O. 

  

	 	5.	Cabinetry: Plastic laminate finish, countertops and splashes shall be constructed in accordance with WIC manual of Millwork, “Custom” grade. 

 

	 	6.	Hardware: 

  

	 	a.	Hinges: Self-closing type, fully concealed when the doors are closed. Shall have independent vertical, horizontal and depth adjustment. Shall be steel with nickel-plated finish. Hinges shall be one of the following
products: 

 Brass America, Inc. Nos. 1200/1201. 

Julius Blum, Inc. No.91.650. 

Stanley Hardware Nos. 1511-2/1511-9x or equal. 
  

	 	7.	Pulls: 4” X 5/16” diameter wire pulls, brushed chrome finish. U.N.O. 

  

	 	8.	Adjustable Shelf Supports to be hole & pin type, Hafele 282.24.710 5MM steel pin. 

  

	 	9.	Drawers: Provide heavy-duty  3⁄4 extension drawer slides. 

 

	 	10.	Mutes: Clear vinyl dot. 

  

	 	11.	Fasteners and Anchorages: Provide nails, screws, or other anchoring devices of type, size material and finish suitable for intended use and required to provide secure. 

 

	 	12.	Casework: 

  

	 	a.	Drawer Boxes: Provide sub-front and applied finish fronts securely fastened, with square corners and self-edges. Provide drawers with metal studs. 

 

	 	b.	Doors: Flush overlay type with square corners, and self edged. Do not notch door, cabinet ends or dividers to receive hinges. 

  

	 	c.	Shelves:  3⁄4“ thick for spans up to 35” and 1” thick for spans over 35” up to 48” and adjustable to
1” centers. Do not recess metal shelf standards into end panels; notch shelving to clear standards. 

 TENANT SUITE FINISH
MATERIALS 
  

	A.	PAINT 

 Field Color: Kelly Moore # 20 Western Acoustic (accent colors within open
areas may be used at designer’s discretion approved by Ownership). 

  
 EXHIBIT B 

-4- 

	B.	FINISH STANDARD 

  

	          Carpet: 
	Shaw Contract Group: ‘Java’ or ‘Ripple’. 

 Installation: Direct Glue Down. 

 

	          Rubber Base: 
	Johnsonite tight lock wall base #11 Canvas. 2 1/2” cove base at resilient flooring, 2 1/2” straight base at carpet (rolled goods only). 

Rubber transition strip between carpet and resilient flooring, Color to match base. 

 

	          VCT#1: 
	Armstrong ‘Stonetex Vinyl Composite Tile, Color #52139 Limestone Beige or #52128 Desert Dust , 12” x 12” x 1/8”. 

  

	          Plastic Lam.: 
	Formica #756-58 Natural Maple (base cabinet vertical surfaces). 

  

	          Plastic Lam.: 
	Formica #7022-58 Natural Canvas (horizontal surfaces & upper cabinets). 

 HEATING, VENTILATION AND AIR CONDITIONING 

Furnish and install all materials and equipment necessary to provide complete and usable air conditioning systems in tenant spaces including,
but not necessarily limited to, the following: 
  

	 	A.	Requirements shall be in accordance with title 24 and all other applicable codes. 

  

	 	B.	CEILING DIFFUSER SPECIFICATION 

  

	 	a.	Ceiling diffusers shall have perforated face with frame style compatible with the type of ceiling used. Surface mounted diffusers shall have gaskets to prevent leakage. Diffuser faceplate shall have concealed hinges and
latches. Face plates shall be easily removable from the frame. 

  

	 	b.	Diffusers shall be modular core and shall have curved, adjustable blades and shall be capable of delivering 1-way,2-way,3-way or 360 degree horizontal ceiling pattern and be adjustable to obtain a down air pattern.
Diffuser must have high anti-smudge characteristics with center aspiration. 

  

	 	c.	Material shall be steel. Finish shall be Standard White baked enamel. 

  

	 	d.	Supply diffusers shall be Titus modular core PMC perforated face-size 24“x24” for lay-in ceiling tile. 

  

	 	e.	Return/Exhaust diffusers shall be Kruger. 

  

	 	f.	Perforated ceiling diffusers shall be tested in accordance with Air Diffusion Council (ADC) code 10602R4. Sound data for diffusers shall be calculated in accordance with International Standard ISO 3741 Comparison
Method. 

  

	 	g.	The following manufactures shall be considered equal, providing corresponding models meet specific requirements. Equivalent substituted equipment named herein shall be submitted for the Architect’s review. Submit
alternate selections at a time of bid listing major equipment. 

  

	 	h.	Manual dampers in all drops. 

  
 EXHIBIT B 

-5- 

			
	 ITEM
	  	 MANUFACTURER

	AIR FILTERS	  	Kruger
	MIXING BOXES	  	Kruger
	GRILLES	  	Kruger

  

	 	C.	THERMOSTATS 

 Thermostats shall be provided for each zone. Honeywell Pneumatic,
Model TP970A, 2004 
 Direct Acting, Range 60° to 90°, Color White. 

 

	 	D.	SUBMITTALS 

 For Non-Standard Material Lists/Product Data: Within 5-7 days of
contract award, and prior to ordering any materials or equipment, submit for Owner’s review complete material list including catalogue data of material and products for work in this section. 

Note: Install BTU meters for any condenser water usage at tenant cost. 

ELECTRICAL 
  

	 	1.	GENERAL 

  

	 	a.	All work, material or equipment shall comply with the codes, ordinance and regulations of the local government having jurisdiction, including Title 24 and any participating government agencies having jurisdiction.

  

	 	b.	110V duplex outlet in demising or interior partitions only, as Manufactured by Leviton or equal. Color: White. 

  

	 	c.	Maximum eight outlets per 20 amps 3 phase 4-wire circuit, spacing to meet code requirements. Minimum 2 per: office(1 quad with drop for voice/data and 1 duplex on opposite wall), conference room, reception, 2 dedicated
over cabinet at break room; junction boxes above ceiling for large open area with furniture partitions. 

  

	 	d.	Contractors to inspect electric room and base building Electrical drawings to include all necessary metering, connections and additional equipment, i.e., panels and transformers, if needed. Base building provides one
(1) power panel and one (1) lighting panel per electrical room. 

  

	 	e.	Note: Install electric meter for any above-standard electrical usage at Tenant Cost. 

  

	 	2.	RACEWAYS 

  

	 	a.	Conduit shall be rigid galvanized steel (RGS), electrical metallic tubing (EMT), metal clad (MC) cable, polyvinyl, chloride (PVC), and flexible or liquid tight flexible conduit. 

 

	 	b.	Type ‘AC’ and ‘NM’ cable are not acceptable. 

  

	 	c.	Support per seismic zone 4 requirements. 

  
 EXHIBIT B 

-6- 

	 	3.	WIRING DEVICES 

  

	 	a.	Receptacles, toggle switches and coverplates shall be white (dedicated- gray) – Leviton. Mount so that the center of the receptacles is no less than 15” AFF. 

 

	 	b.	Maximum eight (8) outlets per 20 amp 3 phase 4-wire circuit. Spacing to meet code requirements. Amounts to be two duplex outlets per small and three for large private office, storage room and conference room. One
dedicated outlet per copy room; one dedicated 20-amp outlet per telephone panel and one 20-amp circuit per 200 square foot of open area for workstations. 

  

	 	c.	All workstation hardwire connections to be building power to be supplied by tenant. 

  

	 	d.	Transformers to be a minimum of 20% or over required capacity shall be K-=rated dry type. 

  

	 	e.	Contractors to inspect electric room and base building electrical drawings to include all necessary metering and connections. 

  

	 	f.	No aluminum wiring is acceptable. AC and NM cable is not to be used. 

  

	 	g.	Provide separate neutrals for each circuit. Use stranded wire for each circuit. Use copper conductors only, no exception. 

  

	 	h.	Switch assembly to be Leviton. 

  

	 	i.	Motion sensors as required by lighting management system and by Title 24. 

  

	 	4.	TELEPHONE / DATA OUTLETS 

  

	 	a.	One (1) single box to house phone/data jack with pull string from outlet box to area above T-bar ceiling with cover plate per office; Two (2) boxes to house phone/data jack with pull string from outlet box to
area above T-bar ceiling with cover plate per large open area. Cover plate finish required: white, supplied by tenant’s Telcom contractor. Mount so that the center of the receptacles is no less than 15” AFF. 

 

	 	b.	One (1) 6’ wide by 4’ high plywood backboard installed as telephone backboard, brace and secure to wall. Painted to match wall color. Provide one duplex 20 amp dedicated outlet for phone service per above
electrical specification. Provide 2” conduit from floor main phone room to six inches (6”) below ceiling at telephone backboard. 

  

	 	c.	Cable service installation for phone and data outlets by tenant’s telephone/data vendors at tenant’s cost. Additional outlets and cover plates to be provided by tenant’s vendors at tenant’s cost. In
speculative office suites, contractor to provide and install blank cover plates. 

  

	 	d.	Telephone panel boards to be located within tenant space and to be surface mounted. 

  

	 	5.	TRANSFORMERS 

  

	 	a.	Transformers shall be UL listed and suitable for the application- NEMA 1 or 3 R. 

  

	 	b.	Transformers shall be 480V (primary) – 20by/120V (secondary), rated for 80 C rise above an ambient temperature of 40 C. 

  

	 	c.	Support for seismic zone 4 requirements. 

  
 EXHIBIT B 

-7- 

	 	d.	Acceptable manufacturers shall be General Electric, Cutler-Hammer, Siemens, Square D, or Westinghouse. 

  

	 	6.	PANEL BOARDS 

  

	 	a.	Panel boards shall be UL listed and suiteable for the application- NEMA 1 or 3R. 

  

	 	b.	All circuit breakers shall be molded case, bolt-on type. 

  

	 	c.	Support per seismic zone 4 requirements. 

  

	 	d.	Acceptable manufactures shall be General Electric, Cutler-Hammer, Siemens, Square D, or Westinghouse. 

  

	 	7.	LIGHT FIXTURES 

  

	 	a.	Light fixtures shall be 24“x 48“x 3” Parabolic Diffuser with three 32 Watt T8 lamps per fixture size, 1-electronic ballasts. Fixtures shall be Lightolier DPA-2T18-L-S-332-UNV03-18-29187-000M 277 V with
modular wiring and (1) electronic ballast (Advance Ballast #VEL-3P32-SC). Fixtures shall match existing in suite with modular wiring and (1) electronic ballast (verify for 2 or 3 lamp fixture requirement based on energy efficiency
requirement with approximately 50 F.C. at desk height). 

  

	 	b.	Support per seismic zone 4 requirements. 

  

	 	c.	Quantities and locations per plans. 

  

	 	8.	LIGHT CONTROL/SWITCHING 

 Wall occupancy sensors – Mytec #LP-2-DC. 

 

	 	9.	EXIT SIGNS 

  

	 	a.	Edge lite with recessed ceiling mount, floating green letters on a clear panel with LED Technology, by Dualite or equivalent. 

  

	 	b.	Quantities and locations per exiting and lighting plans. 

  

	 	c.	Single or double face and directional arrows per lighting plans. 

 MISCELLANEOUS 

 

	1.	FIRE CAULKING 

  

	 	a.	General Contractor is responsible for all fire caulking required by any and all work done during the process of construction. 

  

	2.	PLUMBING 

  

	 	a.	Shall comply with all local codes and handicapped code requirements. Fixture shall be: Manufacturer Elkay, ‘Hospitality sin” #BPSR-2317 – stainless steel, two faucet holes, or equivalent. Faucet: single
lever post mount bar faucet by ‘Elkay’ #LK-4122 or equivalent. 

  

	 	b.	Plumbing bid shall include 5 gallon minimum hot water heater, or insta-hot with mixer valve including all connections, located within tenant’s suite. 

  
 EXHIBIT B 

-8- 

 EXHIBIT C 

AMENDMENT NO. 6 
 TO

 MARINA VILLAGE OFFICE TECH LEASE 

THIS AMENDMENT NO. 6 TO MARINA VILLAGE OFFICE TECH LEASE (this “Sixth Amendment”) is made and entered into as of
                    , 20            , by and between LEGACY PARTNERS I ALAMEDA, a
Delaware limited liability company (“Landlord”), and INSITE VISION INCORPORATED, a Delaware corporation (“Tenant”). 

R  E  C  I  T  A  L  S  : 

A. Reference is hereby made to that certain Marina Village Industrial Gross Office Tech Lease dated as of September 1, 1996 (the
“Original Lease”) between Alameda Real Estate Investments, a California limited partnership (“Alameda”) and Tenant, as amended by that certain: (i) Amendment No. 1 to Marina Village Office Tech Lease dated
July 20, 2001 (the “First Amendment”) between Alameda and Tenant; (ii) Amendment No. 2 to Marina Village Office Tech Lease dated August 1, 2003 (the “Second Amendment”) between Alameda and
Tenant; (iii) Amendment No. 3 to Marina Village Office Tech Lease dated November 21, 2006 (the “Third Amendment”) between Landlord (successor-in-interest to Alameda) and Tenant; and (iv) Amendment No. 4 to
Marina Village Office Tech Lease dated April 1, 2007 (the “Fourth Amendment”) between Landlord and Tenant. Pursuant to the Original Lease (as amended by the First Amendment, Second Amendment, Third Amendment and Fourth
Amendment), Tenant leased from Landlord the following (collectively, the “Original Premises”): (i) that certain premises commonly known as Suites 100, 103 and 104, containing approximately 20,254 rentable square feet of
space (collectively, the “Challenger Premises”) comprising the entire rentable area of that certain building addressed as 2020 Challenger Drive, Alameda, California (the “Challenger Building”); and (ii) that
certain premises commonly known as Suite 100, containing approximately 18,869 rentable square feet of space (the “Original Atlantic Premises”) located in that certain building addressed as 965 Atlantic Avenue, Alameda,
California (the “Atlantic Building”).  
 B. Landlord and Tenant entered into that certain Amendment
No. 5 to Marina Village Office Tech Lease dated as of May 31, 2013 (the “Fifth Amendment”), pursuant to which the Original Premises were expanded to include approximately 5,042 rentable square feet of space located in the
Atlantic Building (the “Atlantic Expansion Space”) and comprising the balance of the rentable area of the Atlantic Building. The Original Premises and the Atlantic Expansion Space are collectively referred to herein as the
“Premises”. The Original Lease, the First Amendment, the Second Amendment, the Third Amendment, the Fourth Amendment and the Fifth Amendment are collectively referred to herein as the “Lease”. 

C. Except as otherwise set forth herein, all capitalized terms used in this Fifth Amendment shall have the same meaning as given such terms in
the Lease. 

  
 EXHIBIT C 

-1- 

 D. Landlord and Tenant desire to amend the Lease to confirm the Atlantic Expansion Space
Commencement Date, as hereinafter provided. 
 NOW, THEREFORE, in consideration of the foregoing Recitals and the mutual covenants contained
herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

1. Confirmation of Dates. The parties hereby confirm that the Atlantic Expansion Space Term commenced as of
            (the “Atlantic Expansion Space Commencement Date”) for a term ending on December 31, 2020 (unless sooner terminated as provided in the Lease, as hereby
amended, or extended pursuant to Section 8 of the Fifth Amendment). The Second Extended Term with respect to the Challenger Premises and the Original Atlantic Premises shall also expire on December 31, 2020 (unless sooner terminated as
provided in the Lease, as hereby amended, or extended pursuant to Section 8 of the Fifth Amendment). 
 2. No Further
Modification. Except as set forth in this Sixth Amendment, all of the terms and provisions of the Lease shall remain unmodified and in full force and effect. 

[SIGNATURES APPEAR ON THE FOLLOWING PAGE] 

  
 EXHIBIT C 

-2- 

 IN WITNESS WHEREOF, this Sixth Amendment to Lease has been executed as of the day and year first
above written. 
  

					
	LANDLORD:	 		 	LEGACY PARTNERS I ALAMEDA, LLC,
		 		 	a Delaware limited liability company,
		 		 	Owner
			
		 		 	 By: Legacy Partners Commercial, L.P.,

      a California limited partnership,

      as Property Manager and Agent for Owner

			
		 		 	      By: Legacy Partners Commercial, Inc.,
		 		 	              its General Partner

  

					
		 		 	
By:                         
                                         
           
 Name: Hanna Eyal

Its: Senior Vice President
 DRE #01178811

BL DRE #01464134

  
  

							
	TENANT:	 		 	 INSITE VISION INCORPORATED,
 a
Delaware corporation

				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:  
				
		 		 	By:	 	  

		 		 		 	Name:
		 		 		 	Title:

  
 EXHIBIT C 

-3- 

 EXHIBIT D 

SCOPE OF WORK 
  

	1.	Replace all obsolete HVAC air handlers at the Atlantic Building. This will include providing the required cooling capacity for Tenant’s existing stability room and Server Room (currently deficient).

  

	2.	Replace the obsolete boiler(s) at the Atlantic Building. 

  

	3,	Replace the existing obsolete generator at the Atlantic Building with a new unit having a minimum output of 110 kw. 

  

	4.	Provide new fume hood fan replacements of all existing units at the Atlantic Building (11-12 hoods). 

  

	5.	Paint the entire Premises in both Buildings. 

  

	6.	Replace carpet in all areas which are currently carpeted in both Buildings. 

  

	7.	Paint over the removed “InSite Vision” sign on the façade of the Atlantic Building. 

  

	8.	Provide connectivity/integration of the Existing Premises and the Atlantic Expansion Space as required by Tenant including matching of paint and carpet. 

 

	10.	Repair or replacement of latches on the entry doors to both Buildings. 

  

	11.	Replacement of broken urinals and antiquated toilets in the restrooms in both Buildings (14 in the Challenger Building and 7 in the Atlantic Building). 

  
 EXHIBIT D 

-1- 

 EXHIBIT E 

FORM OF CURRENT SNDA 
 Recording
requested by and when 
 recorded, return to: 
 InSite Vision
Incorporated 
 965 Atlantic Avenue 
 Alameda, California 94501

 Attn: Mary-Anne Leontiades 

SUBORDINATION, NON-DISTURBANCE AND ATTORNMENT AGREEMENT 

This Subordination, Non-Disturbance and Attornment Agreement (this “Agreement”) is dated as of the
                    day of             , 2013, between U.S. BANK NATIONAL ASSOCIATION,
AS SUCCESSOR BY APPOINTMENT TO WELLS FARGO BANK, N.A., AS TRUSTEE FOR THE CERTIFICATEHOLDERS OF THE J.P. MORGAN CHASE COMMERCIAL MORTGAGE SECURITIES CORP., COMMERCIAL MORTGAGE PASS-THROUGH CERTIFICATES, SERIES 2006-FL2
(“Lender”), and INSITE VISION INCORPORATED, a Delaware corporation (“Tenant”). 

RECITALS 
 A.
Lender is the present owner and holder of a certain loan (the “Loan”) originally made in the face principal amount of $157,000,000.00 by Secore Financial Corporation (“Initial Lender”) to Legacy Partners I Alameda, LLC, a
Delaware limited liability company (“Landlord”), which Loan is presently evidenced by, among other documents and instruments, that certain Amended and Restated Promissory Note, dated as of June 1, 2011, made by Landlord payable to the
order of Lender in the face principal amount of $147,100,035.74 (the “Note”), and secured by, among other documents and instruments, that certain Deed of Trust, Assignment of Leases and Rents, Security Agreement and Fixture Filing, dated
as of February 14, 2006 (as modified from time to time, the “Deed of Trust”), made by Landlord to First American Title Insurance Company, as trustee for the benefit of Initial Lender, and recorded as Instrument # 1006058119 in the
Alameda County, California records (the “Records”), and that certain Assignment of Leases and Rents, dated as of February 14, 2006 (, as modified from time to time, the “Assignment of Leases”; the Deed of Trust, the
Assignment of Leases and all other security documents now or hereafter securing the Loan are hereinafter referred to collectively as the “Security Documents”; the Note and the Security Documents, together with any and all other documents
and instruments evidencing or guaranteeing the Loan, are herein referred to collectively as the “Loan Documents”), made by Landlord for the benefit of Initial Lender, and recorded as Instrument # 2006058120 in the Records, which Security
Documents encumber certain property located in Alameda County, California, more specifically described therein (the “Premises”). 

  
 EXHIBIT E 

-1- 

 B. Tenant is the lessee under that certain Marina Village Office Tech Lease dated
September 1, 1996 (the “Original Lease”) between Alameda Real Estate Investments, a California limited partnership (“Alameda”) and Tenant, which Original Lease has been previously amended by Amendment No. 1 to Marina
Village Office Tech Lease dated July 20, 2001 between Alameda and Tenant, Amendment No. 2 to Marina Village Office Tech Lease dated August 1, 2003 between Alameda and Tenant, Amendment No. 3 to Marina Village Office Tech Lease
dated November 21, 2006 between Landlord (successor-in-interest to Alameda) and Tenant, Amendment No. 4 to Marina Village Office Tech Lease dated April 1, 2007 between Landlord and Tenant, and Amendment No. 5 to Marina Village
Office Tech Lease dated as of May 31, 2013 between Landlord and Tenant (the Original Lease, as so amended, the “Lease”), covering certain premises as described therein (the “Leased Premises”). 

C. Tenant has agreed that the Lease is and shall be subordinate to the Security Documents and to the lien thereof, and Lender has agreed to
grant non-disturbance to Tenant under the Lease, all on the terms and conditions hereinafter set forth. 
 AGREEMENT 

For mutual consideration, including the mutual covenants and agreements set forth below, the receipt and sufficiency of which are hereby
acknowledged, the parties hereto agree as follows: 
 1. Tenant agrees that the Lease is, and shall remain, subject and subordinate to the
Security Documents and to all present or future advances under the obligations secured thereby and all renewals, amendments, modifications, consolidations, replacements and extensions of the secured obligations and the Security Documents, to the
full extent of all amounts secured by the Security Documents from time to time. Said subordination is to have the same force and effect as if the Security Documents and such renewals, modifications, consolidations, replacements and extensions
thereof had been executed, acknowledged, delivered and recorded prior to the Lease, any amendments or modifications thereof and any notice thereof. 

2. Lender agrees that, if Lender exercises any of its rights under the Security Documents, including the exercise of any of its foreclosure
rights under the Deed of Trust, Lender shall not disturb Tenant’s right of quiet possession and enjoyment of the Leased Premises under the terms of the Lease so long as Tenant is not then in default after proper notice and beyond any applicable
grace period of any term, covenant or condition of the Lease as would entitle Landlord to terminate the Lease. Further, Lender shall not include Tenant or any sublessee of Tenant in any foreclosure proceeding involving the Property, unless required
by applicable state law for Lender to accomplish the foreclosure. 
 3. Tenant agrees that, in the event of a foreclosure of the Deed of
Trust by Lender or Lender’s nominee or affiliate or the acceptance of a deed in lieu of foreclosure by Lender or Lender’s nominee or affiliate or any other succession of Lender or Lender’s nominee or affiliate or any other transferee
to fee ownership of the Leased Premises, Tenant will attorn to and recognize, as applicable, Lender, its successors and assigns, any purchaser of the Leased Premises upon such a foreclosure of the Deed of Trust, or any other transferee to fee
ownership of the Leased Premises (each of the foregoing parties, as applicable, a “Successor Owner”), as its 

  
 EXHIBIT E 

-2- 

 
landlord under the Lease for the remainder of the term of the Lease (including all extension periods which have been or are hereafter exercised) upon the same terms and conditions as are set
forth in the Lease, and Tenant hereby agrees to pay and perform all of the obligations of Tenant pursuant to the Lease. Such attornment and the non-disturbance provisions in paragraph 2 above shall be effective and self-operative without the
execution of any further instruments by any party hereto. Nothing in this clause or otherwise under this Agreement shall be deemed to waive any rights or remedies Tenant may have against Landlord with regard to the Lease (as amended) or Leased
Premises. 
 4. Tenant agrees that, in the event a Successor Owner succeeds to the interest of Landlord under the Lease, such Successor
Owner shall not be: 
 (a) liable for any act or omission of any prior landlord (including, without limitation, Landlord), except as may be
expressly set forth in this Agreement, or 
 (b) except as expressly provided in Sections 5 and 6, below, subject to any defenses or offsets
which Tenant may have against any prior landlord (including, without limitation, Landlord), or 
 (c) bound by any payment of rent or
additional rent which Tenant might have paid for more than one month in advance of the due date under the Lease to any prior landlord (including, without limitation, Landlord), or 

(d) bound by any surrender, termination, amendment or modification of the Lease made without the prior written consent of such Successor
Owner, or 
 (e) except as expressly provided in Section 5, below, obligated to cure any defaults of any prior landlord (including,
without limitation, Landlord) under the Lease which occurred prior to the date on which such Successor Owner succeeded to the prior landlord’s interest under the Lease; it being understood and agreed, however, that if such Successor Owner
elects not to cure any such defaults, Tenant shall retain any rights and remedies Tenant has under the Lease or at law against such prior landlord and, to the extent set forth in Section 5 below, against Successor Owner, or 

(d) liable or bound by any right of first refusal or option to purchase all or any portion of the Leased Premises, if any, that are not
contained in the Lease or otherwise separately consented to by Lender. 
 5. Tenant also agrees that any Successor Owner shall be liable
only for the performance of the obligations of the landlord under the Lease which arise during the period of its or their ownership of the Leased Premises and shall not be liable for any obligations of the landlord under the Lease which arise prior
to such ownership; it being understood and agreed, however, that (i) Successor Owner shall be responsible for curing any then existing defaults on the part of landlord under the Lease if and to the extent necessary to fulfill any continuing
obligations of the landlord under the Lease, including, without limitation, making any repairs to the Building or the Leased Premises necessary to maintain the Leased Premises in accordance with the terms of the Lease even if some or all of the
damage necessitating such repairs occurred prior to the date upon which Successor Owner acquired title to the Leased Premises, and (ii) until 

  
 EXHIBIT E 

-3- 

 
any such existing defaults are cured, Tenant shall retain any rights and remedies Tenant has under the Lease or at law, including, without limitation, any rent abatement rights. Tenant further
agrees that any such liability shall be limited to the interest of Successor Owner in the Leased Premises, and Tenant shall not be able to enforce any such liability against any other assets of Successor Owner. 

6. Tenant hereby agrees to give to Lender or any Successor Owner copies of all notices of Landlord default(s) under the Lease in the same
manner as, and whenever, Tenant shall give any such notice of default to Landlord, and no such notice of default shall be deemed given to Landlord unless and until a copy of such notice shall have been so delivered to Lender or such Successor Owner,
respectively. Lender or any Successor Owner shall have the right to remedy any Landlord default under the Lease, or to cause any default of Landlord under the Lease to be remedied, and for such purpose Tenant hereby grants Lender or such Successor
Owner, respectively, such additional period of time (not to exceed 120 days) as may be reasonable under the circumstances to enable Lender or such Successor Owner, respectively, to remedy, or cause to be remedied, any such default in addition to the
period given to Landlord for remedying, or causing to be remedied, any such default. Tenant shall accept performance by Lender or any Successor Owner of any term, covenant, condition or agreement to be performed by Landlord under the Lease with the
same force and effect as though performed by Landlord. No Landlord default under the Lease shall exist or shall be deemed to exist (i) as long as Lender or any other Successor Owner, in good faith, shall have commenced to cure such default
within the above referenced time period and shall be prosecuting the same to completion with reasonable diligence, subject to force majeure, or (ii) if possession of the Leased Premises is required in order to cure such default, or if such
default is not susceptible of being cured by Lender, as long as Lender, in good faith, shall have notified Tenant that Lender intends to institute proceedings under the Security Documents, and, thereafter, as long as such proceedings shall have been
instituted and prosecuted with reasonable diligence, and as long as such proceedings do not exceed 120 days. In the event of an election by Tenant to terminate the Lease by reason of any default thereunder by Landlord, upon Lender’s or any
Successor Owner’s written request, given within fifteen (15) days after notice by Tenant of its intent to terminate the Lease, Tenant, within fifteen (15) days after receipt of such request, shall execute and deliver to Successor
Owner a new lease of the Leased Premises for the remainder of the term of the Lease upon all of the terms, covenants and conditions of the Lease, with the only change being the identity of the landlord thereunder, provided in all such cases,
Successor Owner satisfactorily cures the default which gave rise to the termination. Lender shall have the right, without Tenant’s consent, to foreclose the Security Documents or to accept a deed in lieu of foreclosure of the Deed of Trust or
to exercise any other remedies under the Security Documents. 
 7. Tenant hereby acknowledges that it has been advised that Landlord
assigned the Lease and the rents thereunder to Lender pursuant to the Security Documents. Tenant hereby acknowledges that the interest of the Landlord in the Lease and the rents thereunder were assigned to Lender solely as security for the purposes
specified in the Security Documents, and Lender shall have no duty, liability or obligation whatsoever under the Lease or any extension or renewal thereof, either by virtue of the Security Documents or by any subsequent receipt or collection of
rents thereunder, unless Lender shall specifically undertake such liability in writing or unless Lender or its designee or nominee becomes the fee owner of the Leased Premises (and in such event, subject to such limitations as are expressly set
forth in this Agreement). Tenant 

  
 EXHIBIT E 

-4- 

 
and Landlord agree that upon receipt by Tenant of a written notice from Lender of a default by Landlord under the Loan, Tenant will thereafter, if requested by Lender, pay to Lender all rent and
other sums payable under the Lease. 
 8. Tenant hereby covenants and agrees that: (i) the Lease shall not be assigned or sublet by
Tenant, modified, amended or terminated (except a termination that is permitted in the Lease without Landlord’s consent) without Lender’s prior written consent in each instance; (ii) Tenant shall not pay any rent or additional rent
under the Lease more than one month in advance; (iii) Tenant shall not voluntarily subordinate the Lease to any lien or encumbrance (other than the Security Documents) without Lender’s prior written consent; (iv) Tenant shall deliver
to Lender, from time to time and within ten (10) days from the date of request, but not more frequently than once in any 24 month period, a written statement certifying to Lender that the Lease is in full force and effect (if that is the case),
that there are no defaults there under by Landlord, or specifying any defaults that then exist, that the Lease has not been modified or amended, or specifying any modifications or amendments, the rent then in effect and the date through which is has
been paid, the amount of any security deposit, whether Tenant has then accepted the leased premises, whether the Lease has been assigned or sublet by Tenant, the Lease term commencement and expiration dates, describing any options to extend or
expand that are contained in the Lease, and that Tenant has no options or rights to purchase any of the Property. 
 9. Landlord
acknowledges and agrees for itself and its heirs, representatives, successors and assigns, that: (a) nothing contained in this Agreement is intended to create or constitute, and nothing shall be deemed or construed to create a constitute, a
waiver, modification, relinquishment or forbearance by Lender of any of Lender’s rights or remedies under any of the Loan Documents or at law or in equity, including, without limitation, any rights and remedies in connection with any defaults
or events of default that may now or hereafter exist under any of the Loan Documents; (b) nothing contained in this Agreement is intended to, and nothing shall be deemed to release Landlord from its obligations to comply with the terms,
provisions, conditions, covenants, agreements and clauses of the Loan Documents; (c) the provisions of the Loan Documents remain in full force and effect and must be complied with by Landlord; and (d) Tenant is hereby authorized to pay its
rent and all other sums due under the Lease directly to Lender upon receipt of a notice as set forth in Section 7 of this Agreement from Lender and that Tenant is not obligated to inquire as to whether a default actually exists under the Loan,
and Tenant shall have no liability to Landlord for making payments to Lender upon receipt of such a notice. 

  
 EXHIBIT E 

-5- 

 10. Any notice, election, communication, request or other document or demand required or
permitted under this Agreement shall be in writing and shall be deemed delivered on the earlier to occur of (a) receipt or (b) the date of delivery, refusal or nondelivery indicated on the return receipt, if deposited in a United States Postal
Service Depository, postage prepaid, sent certified or registered mail, return receipt requested, or if sent via a recognized commercial courier service providing for a receipt, addressed to Tenant or Lender, as the case may be, at the following
addresses: 
  

	 	If to Tenant:	InSite Vision Incorporated 

	 	 	965 Atlantic Avenue 

	 	 	Alameda, California 94501 

	 	 	Attn: Mary-Anne Leontiades 

  

	 	If to Lender:	U.S. Bank National Association, as 

	 	 	successor by appointment to the Wells 

	 	 	Fargo Bank, N.A., as Trustee for the 

	 	 	Certificateholders of the J.P. Morgan Chase 

	 	 	Commercial Mortgage Securities Corp., 

	 	 	Commercial Mortgage Pass-Through 

	 	 	Certificates, Series 2006-FL2 

	 	 	c/o TriMont Real Estate Advisors, Inc. 

	 	 	3424 Peachtree Road NE, Suite 2200 

	 	 	Atlanta, GA 30326 

	 	 	Attention: Mr. J. Gregory Winchester, 

	 	 	Reference: Marina Village/Series 2006-FL2 

 11. This Agreement shall inure to the benefit of
the parties hereto, their respective successors and permitted assigns, and any Successor Owner, and its heirs, personal representatives, successors and assigns. 

12. If any provision of this Agreement is held to be invalid or unenforceable by a court of competent jurisdiction, such provision shall be
deemed modified to the extent necessary to be enforceable, or if such modification is not practicable, such provision shall be deemed deleted from this Agreement, and the other provisions of this Agreement shall remain in full force and effect, and
shall be liberally construed in favor of Lender or any Successor Owner, as applicable. 
 13. Neither this Agreement nor any of the terms
hereof may be terminated, amended, supplemented, waived or modified orally, but only by an instrument in writing executed by the party against which enforcement of the termination, amendment, supplement, waiver or modification is sought. 

14. This Agreement shall be construed in accordance with the laws of the state of in which the Leased Premises is located. 

15. The person executing this Agreement on behalf of Tenant is authorized by Tenant to do so and execution hereof is the binding act of Tenant
enforceable against Tenant. 
 16. This Agreement may be executed in one or more counterparts, and it shall be deemed fully executed when
each party hereto has executed a counterpart. A facsimile or email of an executed counterpart shall be deemed an original executed counterpart and fully effective as such for all purposes. 

(SIGNATURES AND ACKNOWLEDGMENTS APPEAR ON FOLLOWING PAGES) 

  
 EXHIBIT E 

-6- 

 IN WITNESS WHEREOF, this Agreement has been duly executed by the parties hereto as of the
day and year first above written. 
  

							
		 	LENDER:
		
		 	U.S. BANK NATIONAL ASSOCIATION, AS SUCCESSOR BY APPOINTMENT TO WELLS FARGO BANK, N.A., AS TRUSTEE FOR THE CERTIFICATEHOLDERS OF THE J.P. MORGAN CHASE COMMERCIAL MORTGAGE SECURITIES CORP., COMMERCIAL MORTGAGE
PASS-THROUGH CERTIFICATES, SERIES 2006-FL2
			
		 	By:	  	TRIMONT REAL ESTATE ADVISORS, INC.,
		 		  	a Georgia corporation, as special servicer
				
		 		  	By:	  	  

		 		  		  	Name: Lynn McKee
		 		  		  	Title:   Senior Vice President

 ACKNOWLEDGMENT OF LENDER 

State of
                                ) 

County of
                            ) 

On
                            , before me,
                                         
               (insert name and title of the officer), personally appeared
                                         
       , who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their
authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 

I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct. 

WITNESS my hand and official seal. 
 Signature
                                         
                (Seal) 
 (SIGNATURES AND
ACKNOWLEDGEMENTS CONTINUE ON NEXT PAGE) 

  
 EXHIBIT E 

-7- 

 
			
	TENANT:
	
	INSITE VISION INCORPORATED,
	a Delaware corporation
		
	By:	 	  

		 	Name:
		 	Title:

 ACKNOWLEDGMENT OF TENANT 

State of
                            ) 

County of                         )

 On
                            , before me,
                                    (insert name and title of the
officer), personally appeared
                                        , who
proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the same in his/her/their authorized capacity(ies), and that by
his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
 I certify
under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct. 
 WITNESS my hand and official seal.

 Signature
                                     (Seal) 

(SIGNATURES AND ACKNOWLEDGEMENTS CONTINUE ON NEXT PAGE) 

  
 EXHIBIT E 

-8- 

 LANDLORD: 

Executed for the purposes of indicating its acknowledgment of and consent to this Agreement, including, without limitation, its acknowledgment and agreement to
Section 9 of this Agreement. 
 LEGACY PARTNERS I ALAMEDA, 

LLC, a Delaware limited liability company 
 Owner

  

			
	By:	 	Legacy Partners Commercial, L.P.,
		 	  a California limited partnership,
		 	  as Property Manager and Agent for Owner
		
		 	 By: Legacy Partners Commercial, Inc.,

		 	       its General Partner

  

					
		 	By:	 	  

	  
	 	 Name: Hanna Eyal
 Its: Senior Vice
President
 DRE #01178811
 BL DRE #01464134

  
 EXHIBIT E 

-9- 

 ACKNOWLEDGMENT OF LANDLORD 

ACKNOWLEDGMENT 
 State of California
                        ) 
 County
of San Mateo                    ) 
 On
                                         
               , before
me,                                         
                                         
                   , 
 (insert
name of notary) 
 Notary Public, personally appeared
                                         
                                         
          , who proved to me on the basis of satisfactory evidence to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they executed the
same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 

I certify under PENALTY OF PERJURY under the laws of the State of California that the foregoing paragraph is true and correct. 

WITNESS my hand and official seal. 

Signature                        
                                    
                        (Seal) 

(END OF SIGNATURES AND ACKNOWLEDGEMENTS) 

  
 EXHIBIT E 

-10- 

 EXHIBIT F 
  

 

  
 EXHIBIT F 

-1- 

  
 

 

  
 EXHIBIT F 

-2-

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