Document:

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Exhibit No.
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  10.50       Contract change No. 4 to SMUD I.

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                                                                    Page 1 of 1

                                                                CONTRACT CHANGE

SMUD LOGO

SACRAMENTO MUNICIPAL UTILITY DISTRICT 6201 S Street, P.O. Box 15830,
Sacramento CA 95852-1830 (918) 452-3211
                                                       -------------------------
CONTRACT NO.     H-126       CHANGE NO.     4            FOR INTERNAL USE ONLY
            ---------------             ----------     -------------------------

       DARPA Fuel Cell Hybrid Vehicle Project          W.O./DIST. NO.___________
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                 CONTRACT TITLE                        PROJECT _________________

Development of reformer and fuel cell power system     COST CENTER _____________
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                 CONTRACT SCOPE                        RESOURCE ________________

            for hybrid electric bus
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THIS AGREEMENT made by and between SACRAMENTO MUNICIPAL UTILITY DISTRICT,
hereinafter designated as SMUD, and H POWER SYSTEMS CORPORATION, hereinafter
designated as H Power. WITNESSETH; That the parties hereto mutually agree to
the following changes in the above numbered contract between the parties,
hereinafter called the "original contract":

AMEND SECTION 6, TERM, AS FOLLOWS:

6. TERM. This Agreement shall commence upon the effective date and shall,
unless earlier terminated pursuant to paragraph 26, and subject to paragraph
26, continue in effect until October 1, 2000.

REPLACE SECTION 13, PROJECT PROPERTY OWNERSHIP, WITH THE FOLLOWING:

13. PROJECT PROPERTY OWNERSHIP. Title to all nonexpendable and expendable
tangible personal property purchased or otherwise created through the direct
Project work of H Power shall be deemed to have vested in H Power upon
purchase, fabrication, manufacture or by other means of acquisition. The
Project vehicle which will result from completion of vehicle integration
activities of H Power and other participants in the Project, as further
described in the Statement of Work, will remain in complete and functional
condition, with fuel cell power system installed, until such time as H Power
determines that the power system must be removed, but not earlier than
October 1, 2000. The parties may extend this time by mutual written agreement.

This Contract Change is subject to all provisions of the original contract
and all provisions of any previous Contract Changes which are not expressly
superseded in this Contract Change.

                                                    H POWER CORPORATION
SACRAMENTO MUNICIPAL UTILITY DISTRICT       ------------------------------------
                                                          CONTRACTOR

By  /s/ Jan Schori           4/28/00        By  /s/ Arthur Kaufman       5/11/00
  ----------------------------------          ----------------------------------
                              DATE                                        DATE

Type Name         JAN SCHORI                Type Name         ARTHUR KAUFMAN
         ---------------------------                  --------------------------

Title       General Manager                 Title      Vice President
     -------------------------------              ------------------------------

CONTRACT TEMPLATE<PAGE>

                                                                   Exhibit 10.32

     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                LICENSE AGREEMENT
                MICHIGAN FILE [**], [**], [**] & [**] TECHNOLOGY

This Agreement is effective as of the 30th day of November, 1997 (the "Effective
Date"), between Reprogenesis, Inc., a Texas corporation with offices located at
10 Sylvan Drive, Suite 27, St. Simons Island, Georgia 31522 ("LICENSEE"), and
the Regents of the University of Michigan, a constitutional corporation of the
State of Michigan ("MICHIGAN"). LICENSEE and MICHIGAN agree as follows:

1.    BACKGROUND.

1.1   MICHIGAN has developed rights, including potential patent rights, in
      "TECHNOLOGY" as defined below.

1.2   MICHIGAN has granted to LICENSEE an option to enter into this Agreement
      under an option agreement made effective on July 1, 1996.

1.3   LICENSEE has timely exercised its option under such option agreement and
      MICHIGAN has extended the exercise period stated therein until and
      including November 30, 1997.

1.4   LICENSEE desires to obtain, and MICHIGAN, consistent with its mission of
      education and research, desires to grant, a license to the TECHNOLOGY on
      the terms and conditions listed below.

2.    DEFINITIONS.

2.1   "Affiliate(s)" means any individual, corporation, partnership,
      proprietorship or other entity controlled by, controlling, or under common
      control with LICENSEE through equity ownership, ability to elect
      directors, or because a majority of directors overlap, and includes any
      individual, corporation, partnership, proprietorship or other entity
      directly or indirectly owning, owned by or under common ownership with
      LICENSEE to the extent of twenty-five percent (25%) or more of the voting
      shares, including shares owned beneficially by such party.

2.2   "Field(s) of Use" refers to the field or fields for which "Products" (as
      defined in Paragraph 2.10 below) may be designed, manufactured, used
      and/or marketed under this Agreement, and means all fields of use.

2.3   "Confidential Information" means any confidential or proprietary
      information furnished by one Party (the "Disclosing Party") to the other
      Party (the "Receiving Party") as required by this Agreement, provided that
      such information is designated as confidential as set out in Paragraph
      30.1 (Confidential Information includes, without limitation, royalty
      reports furnished to MICHIGAN under Article 5, but specifically excludes
      the totals of royalties paid to MICHIGAN, and the existence and terms of
      this Agreement).
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2.4   "First Commercial Reagent Sale" means the first sale of any Product by
      LICENSEE or an Affiliate or "Sublicensee" (as defined in Paragraph 2.12
      below), if such Product is not sold as a drug, device or biologic for use
      in the practice of veterinary or human medicine either alone or in
      combination with other substances, and requires no governmental approval
      or license to be marketed.

2.5   "First Commercial Sale" means the first sale not a First Commercial
      Reagent Sale of any Product by LICENSEE or an Affiliate or Sublicensee,
      other than sale of a Product for use in field trials or in clinical trials
      being conducted to obtain FDA or other governmental approvals to market
      Products. LICENSEE shall demonstrate to MICHIGAN's reasonable satisfaction
      that such sale is an arm's length transaction entered into in good faith
      between buyer and LICENSEE or an Affiliate or Sublicensee.

2.6   "Gross Sublicensing Revenues" means all amounts received and all other
      consideration received (or, when in a form other than cash or its
      equivalent, the fair market value thereof when received) by LICENSEE and
      its Affiliates under any sublicense to a Sublicensee, and as a result of
      any use, distribution, or sale of Products (as defined in Paragraph 2.10
      below) where Net Sales does not include such amounts and other
      consideration.

2.7   "Licensed Patent(s)" means all patents and patent applications, all
      foreign equivalent patent applications and Patent Cooperation Treaty
      filings, and all patents issuing therefrom, in which MICHIGAN has or
      acquires a property interest, and

      (1) which cover an invention included in the TECHNOLOGY (Appendix A lists
          the patent applications currently filed on inventions included in the
          TECHNOLOGY), or

      (2) which this definition includes by operation of Paragraph 9.3 of this
          Agreement.

2.8   "Net Sales" means the sum, over the term of this Agreement, of all amounts
      received and all other consideration received (or, when in a form other
      than cash or its equivalent, the fair market value thereof when received)
      by LICENSEE and its Affiliates from persons or entities due to or by
      reason of the sale, distribution or use of Products, less the following
      deductions and offsets, but only to the extent such sums are otherwise
      included in the computation of Net Sales, or are paid by LICENSEE and not
      otherwise reimbursed: refunds, rebates, replacements or credits actually
      allowed and taken by purchasers for return of Products; customary trade,
      quantity and cash discounts actually allowed and taken; excise,
      value-added, and sales taxes actually paid by LICENSEE for Products; and
      shipping and handling and shipping insurance charges actually paid by
      LICENSEE for Products. (Note that amounts not actually received, such as
      bad debts left unpaid to LICENSEE, are not included in Net Sales.)

2.9   "Parties" in singular or plural usage as required by the context means
      LICENSEE and/or MICHIGAN.

2.10  "Product(s)" means any product (s) (including any service or process to be
      performed for customers) whose manufacture, use or sale (or performance)
      in any country would, but

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     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

      for this Agreement, comprise an infringement, including contributory
      infringement, of one or more Valid Claims.

2.11  "Royalty Quarter(s)" means the three-month periods ending on the last day
      of March, June, September and December of each year.

2.12  "Sublicensee(s)" means any person or entity, except an Affiliate,
      sublicensed by LICENSEE under this Agreement to make, have made, use,
      market, sell, lease, or offer for sale, in the Territory, Products
      designed and marketed for use in a Field of Use.

2.13  "TECHNOLOGY" as used in this Agreement means all information,
      manufacturing techniques, data, designs or concepts (whether or not
      publicly known or available) covering:

      (1) [**] developed by MICHIGAN's employees Wai Hung Wong, David J. Mooney,
          Jon A. Rowley, and Kamal H. Bouhadir as described in MICHIGAN's
          Technology Management office Files No. [**] and [**] entitled,
          respectively, [**], encompassing Provisional U.S. Patent Applications
          Serial No. [**] and Serial No. [**] entitled, respectively, [**] both
          filed on, [**]; and

      (2) [**] developed by MICHIGAN-s employees Kamal H. Bouhadir, Jon A.
          Rowley and David J. Mooney, as described in MICHIGAN's Technology
          management office File No. [**] entitled [**] and encompassing
          Provisional U.S. Patent Application Serial No. [**] of same title
          filed on [**]; and

      (3) [**] developed by MICHIGAN's employees David J. Mooney, Leatrese D.
          Harris, and Lonnie Shea as described in MICHIGAN's Technology
          Management Office File No. [**] entitled [**] and encompassing
          Provisional U.S. Patent Application Serial No. [**] entitled [**] and
          filed on [**];

      (4) the technologies specified in subparagraphs 2.13(l) and 2.13(2) as
          described and claimed in a patent application filed pursuant to the
          Patent Cooperation Treaty on [**], Serial No. PCT/US[**], entitled
          [**].

      (5) all inventions and discoveries in which MICHIGAN acquires ownership
          pursuant to Article 9 below.

2.14  "Territory" means all countries of the world.

2.15  "Valid Claim(s)" means any claim(s) in an unexpired patent or pending in a
      patent application included within the Licensed Patents excepting only
      claims that:

      (1) a court or other governmental agency of competent jurisdiction has
          decided are unenforceable, unpatentable, or invalid, unappealable or
          unappealed within the time allowed for appeal; or

      (2) a reissue or disclaimer has rendered invalid or unenforceable. If in
          any country two or more such decisions conflict with respect to the
          validity of the same claim,

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     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

          the decision of the higher or highest tribunal controls; however, if
          the tribunals are of equal rank, then the decision or decisions
          upholding the claim prevails when the conflicting decisions are equal
          in number, and the majority of decisions prevails when the conflicting
          decisions are unequal in number.

3.    GRANT OF LICENSE.

3.1   MICHIGAN hereby grants to LICENSEE the exclusive license under the
      Licensed Patents to make, have made, use, market, lease, offer for sale
      and sell, in the Territory, Products designed and marketed solely for use
      in any Field of Use; with the right to grant sublicenses to Affiliates and
      Sublicensees subject to the terms and provisions of Article 8 below.

3.2   LICENSEE may maintain periodic communication with MICHIGAN to identify
      intellectual property related to the TECHNOLOGY developed by or under the
      direction of MICHIGAN's faculty member Dr. David Mooney, for possible
      licensing in fields in which LICENSEE is making a current, significant
      commitment. Upon request of LICENSEE (and provided no conflict with any
      then-existing agreements or commitments regarding those technologies would
      result), MICHIGAN will participate in good faith discussions with LICENSEE
      regarding license rights to any such technologies (although LICENSEE
      acknowledges that its right to good-faith discussions may not be exercised
      to exclude other potential licensees from discussions with MICHIGAN).

3.3   MICHIGAN reserves the right to practice the Technology and the Licensed
      Patents solely for research and education purposes.

3.4   MICHIGAN further reserves the right, as 37CFR401.14(b) requires, to grant
      to the U.S. Government a non-exclusive, nontransferable, irrevocable,
      paid-up license or licenses to practice or have practiced for or on behalf
      of the United States all patent applications and resulting patents
      included in the TECHNOLOGY and the Licensed Patents, if agreements between
      MICHIGAN and the U.S. Government covering funded research relating to the
      TECHNOLOGY or the Licensed Patents so require.

4.    CONSIDERATION.

4.1   LICENSEE shall pay to MICHIGAN a one-time license issue fee of [**]
      dollars ($[**]).

4.2   LICENSEE shall also pay to MICHIGAN, with respect to each Royalty Quarter,
      a royalty equal to [**] percent ([**]%) of Net Sales of LICENSEE and
      Affiliate(s) for all Products.

      Reduction of royalties: The royalties payable under Paragraph 4.2 above
      may be reduced by LICENSEE via the following methods:

      Method A: In circumstances where LICENSEE or Affiliates generate Net Sales
      due to the sale of combination products (being a Product sold in
      combination with a discrete system, device, item of equipment or apparatus
      which is not itself a Product), royalties may be calculated only on that
      portion of the overall Net Sales which is left after

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     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

      subtracting the fair market sales price of the discrete system, device,
      item of equipment or apparatus which is not itself a Product (provided
      that, where such Products are also sold separately, the resultant royalty
      shall not be less than if the Product had been sold separately);

      Method B: In circumstances where LICENSEE is required to make payments to
      one or more third parties in consideration for license rights to patents
      or technology necessary to make Products (excluding the discrete
      components of combination products), LICENSEE may deduct [**] percent
      ([**]%) of such payments from the royalties otherwise payable to MICHIGAN.

      Limitation: Where LICENSEE applies either Method A or Method B, the
      royalties payable for the Products so affected shall not be reduced by
      more than [**] ([**]%) of the royalty that would otherwise have been
      payable. Where LICENSEE applies both Method A and Method B to the same
      unit of Product, the royalties payable for the Products so affected shall
      not be reduced by more than [**] ([**]%) of the royalty that would
      otherwise have been payable.

      Method C: In circumstances where LICENSEE or Affiliates expect to sell
      Product(s), directly and in volume, to a horizontal market in which then
      ongoing sales of non-infringing substitute products would materially limit
      the profit margin on sales of Product(s), and LICENSEE or Affiliates
      reasonably demonstrate to MICHIGAN that such market conditions prevail,
      then the Parties agree to meet in advance of such sales and discuss an
      appropriate royalty rate for such Products more accurately reflecting a
      share of the expected profit margin. This negotiated rate shall be applied
      in lieu of the application of Method A or B above to such Net Sales.

4.3   LICENSEE shall also pay MICHIGAN, with respect to each Royalty Quarter, a
      royalty equal to (a) [**] percent ([**]%) of Gross Sublicensing Revenues
      if only rights to Licensed Patents are sublicensed; or (b) [**] ([**]%) of
      Gross Sublicensing Revenues if the Gross Sublicensing Revenues includes
      revenue received for Licensed Patent rights sublicensed in conjunction
      with final end use products developed by LICENSEE and/or substantial
      technology developed by LICENSEE.

4.4   This Agreement imposes the obligation to pay MICHIGAN a royalty under this
      Article 4 only once for the same unit of Product regardless of the number
      of Valid Claims or Licensed Patents covering the same; however, to
      determine payments due, whenever the term "Product" applies to a property
      during various stages of manufacture,. use or sale (including interim
      sales among LICENSEE and its Affiliates where final sales to customers are
      made), then Net Sales equals the amount derived from the sale,
      distribution or use of such Product by LICENSEE or Affiliates at the stage
      of its highest invoiced value to unrelated third parties.

4.5   LICENSEE shall pay to MICHIGAN an annual license maintenance fee. This
      annual fee accrues in the Royalty Quarter ending in March of the years
      specified below. LICENSEE may credit in full each annual fee actually paid
      to MICHIGAN against all royalties (as set forth in Paragraph 4.2 above)
      otherwise due MICHIGAN for the calendar

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     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

      year in which LICENSEE pays the specific annual fee. The year for which
      LICENSEE may take credits against royalties includes the Royalty Quarter
      in which the annual fee accrues and the next three Royalty Quarters.

      The annual license maintenance fees are as follows:

      (1)  In 1997: $[**];

      (2)  In 1998: $[**];

      (3)  In 1999: $[**];

      (4)  In 2000: $[**];

      (5)  In 2001: $[**];

      (6)  In 2002: $[**];

      (7)  In 2003: $[**];

      (8)  In 2004: $[**];

      (9)  In 2005 and in each year thereafter during the term of this
           Agreement: $[**].

      Also, notwithstanding (1-9) above (and in place of the amounts therein
      listed, when applicable):

      (10) In the calendar year following the first year in which. LICENSEE
           first obtains any required governmental approval or license in the
           United States, Japan, or any European Union nation, to market any
           product for any therapeutic purpose as a drug, device or biologic,
           either alone or in combination with other substances: $[**];

      (11) In the year next succeeding the year defined in (10); $[**];

      (12) In the year next succeeding the year defined in (11).; $[**];

      (13) In the year next succeeding the year defined in (12) and in each
           succeeding calendar year thereafter during the term of this
           Agreement; $[**].

      Also, notwithstanding (1-13) above (and in place of the amounts therein
      listed, when applicable):

      (14) In each of the first and second years following the First Commercial
           Sale: $[**].

      (15) In the third year following the First Commercial Sale: $[**].

      (16) In the fourth year following the First Commercial Sale, and in each
           succeeding calendar year thereafter during the term of this
           Agreement: $[**].

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<PAGE>

     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

Also, notwithstanding (1-16) above (and in addition to any amounts therein
listed):

      (17) In each of the first and second years following the First Commercial
           Reagent Sale: $[**].

      (18) In the third year following the First Commercial Reagent Sale: $[**].

      (19) In the fourth year following the First Commercial Reagent Sale, and
           in each year thereafter during the term of this Agreement: $[**].

4.6   Except as provided in the definition of Net Sales, all royalty payments to
      MICHIGAN under this Agreement are without deduction for sales, use,
      excise, personal property or other similar taxes or other duties imposed
      on such payments by the government of any country or any political
      subdivision thereof; and LICENSEE shall assume and pay any such taxes;
      except that LICENSEE may deduct from royalty payments taxes levied upon
      the export of royalties by a government other than the U.S., and required
      to be withheld and paid on MICHIGAN's behalf by LICENSEE (LICENSEE shall
      cooperate in establishing MICHIGAN's exemption from such taxes where
      appropriate).

4.7   In the event that the patents that ultimately issue among the Licensed
      Patents contain only claims that are substantially narrower than the
      claims of the patent applications that are within the Licensed Patents as
      of the Effective Date (that is, if prosecution of the Licensed Patents
      finally results in unexpectedly severe restriction of the coverage of the
      claims), to the competitive detriment of LICENSEE, then MICHIGAN agrees to
      discuss the possibility of renegotiating the royalty rate and other
      financial terms applicable to the affected Product. Any such financial
      relief will be on a country-by-country basis and may be temporary or
      permanent depending upon the circumstances. The Parties acknowledge and
      agree that MICHIGAN is under no legal obligation to alter the financial
      terms set forth in this Article 4, but MICHIGAN is under an obligation to
      enter into discussions with LICENSEE for a reasonable period of time.

5.    REPORTS.

5.1   Annually, until the first to occur of the First Commercial Sale or First
      Commercial Reagent Sale, and thereafter within sixty (60) days after each
      Royalty Quarter closes (including the close of any Royalty Quarter
      immediately following any termination of this Agreement), LICENSEE shall
      report to MICHIGAN for that Royalty Quarter:

      (1)  all royalties accruing to MICHIGAN; and

      (2)  the gross sales and Net Sales of Products by LICENSEE and Affiliates,
           and

      (3)  the source and amount of all Gross Sublicensing Revenues (including,
           where such information is provided to LICENSEE or Affiliates, the
           gross sales and net sales of Products by Sublicensees), and

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      (4)  any other revenues for which payments are due, and the amount of such
           payments, and the various calculations used to arrive at those
           amounts, including the quantity, description (nomenclature and type
           designation), country of manufacture and country of sale of Products.

      If no payment is due, LICENSEE shall so report.

5.2   LICENSEE covenants that it will promptly establish and consistently employ
      a system of specific nomenclature and type designations for Products to
      permit identification and segregation of various types where necessary;
      LICENSEE, Affiliates and Sublicensees shall consistently employ the system
      when rendering invoices thereon and shall inform MICHIGAN, or its
      auditors, when requested, as to the details concerning such nomenclature
      system as well as to all additions thereto and changes therein.

5.3   LICENSEE shall keep, and shall require its Affiliates and Sublicensees to
      keep, true and accurate records and books of account containing data
      reasonably required for the computation and verification of payments due
      as provided by this Agreement. LICENSEE shall:

      (1)  open such books and records for inspection upon reasonable notice
           during business hours by either MICHIGAN auditor(s) or an independent
           certified accountant selected by MICHIGAN, for the purpose of
           verifying the amount of payments due and payable;

      (2)  retain such books and records for six (6) years from date of
           origination.

      These rights of inspection survive any termination of this Agreement.
      MICHIGAN is responsible for all expenses of such inspection, except that
      if any inspection reveals an underpayment greater than ten percent (10%)
      of royalties due MICHIGAN, then LICENSEE shall pay all expenses of that
      inspection and the amount of the underpayment immediately to MICHIGAN.

      MICHIGAN may exercise its rights of inspection under this Paragraph no
      more frequently than once in any twelve (12) month period and shall
      perform such rights of inspection in a manner to minimize unreasonable
      interference with LICENSEE's business operations. The MICHIGAN auditor(s)
      or the independent certified accountant selected by MICHIGAN shall not
      disclose to MICHIGAN any information other than information relating to
      (and information necessary for the proof of) accuracy of reports and
      payments delivered under this Agreement. The confidentiality of such books
      and records shall be protected in accordance with Article 30.

5.4   LICENSEE shall direct its authorized representative to certify that
      reports required hereunder are correct to the best of LICENSEE's knowledge
      and information.

6.    TIMES AND CURRENCIES OF PAYMENTS.

6.1   Payments accrued during each Royalty Quarter are due and payable in Ann
      Arbor, Michigan on the date each quarterly report is due (as provided in
      Paragraph 5.1).

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     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

      LICENSEE shall include such payments, in United States dollars, with the
      report. LICENSEE agrees to make all payments due hereunder to MICHIGAN by
      check made payable to "The Regents of The University of Michigan," and
      sent to MICHIGAN according to the provisions for notices set forth in
      Article 21 herein.

6.2   On all amounts outstanding and payable to MICHIGAN, interest accrues from
      the date the amount is due at [**] above, the prime lending rate as
      established by the Chase Manhattan Bank, N.A., in New York City, New York,
      or at a lower rate if required by law.

6.3   For each Royalty Quarter, LICENSEE and Affiliates shall convert any Net
      Sales or Gross Sublicensing Revenues they receive in foreign currency into
      its equivalent in United States dollars at the exchange rate of the
      currency as reported (or if erroneously reported, as subsequently
      corrected) in the Wall Street Journal on the last business day of the
      Royalty Quarter (or if not reported on that date, as quoted by the Chase
      Manhattan Bank, N.A., in New York City, New York).

6.4   Except as provided in the definition of Net Sales, all royalty payments to
      MICHIGAN under this Agreement are without deduction for sales, use,
      excise, personal property or other similar taxes or other duties imposed
      on such payments by the government of any country or any political
      subdivision thereof; and LICENSEE shall assume and pay any such taxes.

7.    COMMERCIALIZATION.

7.1   LICENSEE assumes full responsibility to do all that is necessary to:

      (1)  obtain any governmental approvals to manufacture or to sell Products;

      (2)  comply with all laws and regulations with respect to Products; and

      (3)  ensure the safe production, storage, handling, transport, packaging
           and distribution of Products.

7.2   LICENSEE agrees to use its best efforts to develop Products, obtain any
      government approvals necessary, and manufacture and sell Products at the
      earliest possible date; and effectively to exploit, market and manufacture
      in sufficient quantities to meet anticipated customer demand and to make
      the benefits of the Products reasonably available to the public.

7.3   LICENSEE agrees to manufacture or have manufactured all Products
      substantially in the United States. If U.S. manufacture is not practically
      feasible, then MICHIGAN shall cooperate with LICENSEE in obtaining waivers
      of this requirement from the U.S. Government.

7.4   LICENSEE shall use its best efforts to alert all potential customers and
      distributees that Products are not intended for any therapeutic or
      clinical diagnostic uses unless properly approved therefor pursuant to
      7.1.

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7.5   Within fifteen (15) days of the First Commercial Reagent Sale, and also
      within fifteen (15) of the First Commercial Sale, LICENSEE shall report by
      written letter to MICHIGAN the date and general terms of such sale.

8.    SUBLICENSING.

8.1   LICENSEE has the exclusive right to grant sublicenses to its rights under
      Article 3 above to Affiliates and Sublicensees, to make, have made, use,
      market, lease, offer for sale and sell, Products in the Territory.

8.2   LICENSEE shall notify MICHIGAN of every sublicense agreement and each
      amendment thereto, within thirty (30) days after their execution, and
      indicate the name of the Sublicensee or Affiliate, the territory of the
      sublicense, the scope of the sublicense, and the nature, timing and
      amounts of all fees and royalties to be paid thereunder.

8.3   LICENSEE shall include in any sublicense granted under this Article 8 a
      provision that the sublicense terminates upon any termination of this
      Agreement.

8.4   LICENSEE shall require that all sublicenses:

      (1)  be consistent with the terms and conditions of this Agreement;

      (2)  contain the Sublicensee's or Affiliate's acknowledgments of
           MICHIGAN's rights in the TECHNOLOGY and Licensed Patents, and the
           disclaimer of warranty and limitation on MICHIGAN's liability, as
           provided by Article 12 below.

      (3)  contain provisions under which the Sublicensee or Affiliate accepts
           duties at least equivalent to those accepted by the LICENSEE in the
           following paragraphs:

           5.3 duty to keep records

           12.4 duty to avoid improper representations or responsibilities

           13.1 duty to defend, hold harmless, and indemnify MICHIGAN

           13.3 duty to maintain insurance

           17  duty to control exports

           19  duty to restrict the use of MICHIGAN's name

           20  duty to properly mark product with Patent notices

8.5   LICENSEE shall require that all sublicenses contain a provision obligating
      each Sublicensee or Affiliate to pay taxes due, if any, in the same manner
      as set out in Paragraph 6.4 above or, should the sublicense be assigned to
      MICHIGAN, to make the Sublicensee or Affiliate responsible for such taxes.

8.6   LICENSEE shall require that all sublicenses contain the right for LICENSEE
      to assign its rights under the sublicense to MICHIGAN.

9.    OWNERSHIP OF INTELLECTUAL PROPERTY.

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9.1   LICENSEE acknowledges MICHIGAN's ownership interest in all Licensed
      Patents as defined in Paragraph 2.7(l) above.

9.2   LICENSEE might engage MICHIGAN employees as employees or consultants to
      LICENSEE or Affiliates during the time of their employment with MICHIGAN.
      LICENSEE and MICHIGAN hereby agree that the following provisions govern
      the rights to any inventions, discoveries or computer software that
      represent improvements upon the Licensed Patents or otherwise relate to
      the TECHNOLOGY whether or not patentable, which any MICHIGAN employee
      conceives, reduces to practice or develops while concurrently employed by
      LICENSEE or Affiliates during the term of his or her employment with
      MICHIGAN and the term of this Agreement:

      (1)  Where MICHIGAN employees concurrently employed by LICENSEE or
           Affiliates, in combination with other LICENSEE or Affiliate employees
           not concurrently employed by MICHIGAN, constitute the group of
           inventors/developers, MICHIGAN and LICENSEE are joint owners of such
           inventions, discoveries and/or computer software, and MICHIGAN and
           LICENSEE shall require that any resulting patent rights and
           copyrights be assigned jointly to MICHIGAN and LICENSEE;

      (2)  Where MICHIGAN employees concurrently employed by LICENSEE or
           Affiliates constitute part or all of the group of
           inventors/developers, and no LICENSEE or Affiliate employees not
           concurrently employed by MICHIGAN constitute any part of the group of
           inventors/developers, LICENSEE shall grant MICHIGAN sole ownership
           (as between MICHIGAN and LICENSEE) of such inventions, discoveries
           and/or computer software, and MICHIGAN and LICENSEE shall require
           that any resulting patent rights and copyrights be assigned solely to
           MICHIGAN.

9.3   Where not precluded by or otherwise conflicting with MICHIGAN's
      then-existing agreements with any third parties, the definition of
      TECHNOLOGY in Paragraph 2.13 above encompasses inventions, discoveries
      and/or computer software included under Subparagraph 9.2(1) or (2) above
      and conceived, reduced to practice or developed during the performance of
      duties as employee or consultant to LICENSEE, and the definition of
      Licensed Patents in Paragraph 2.7 above encompasses any resulting patent
      rights.

10.   PATENT APPLICATIONS AND MAINTENANCE.

10.1  MICHIGAN will control all aspects of filing, prosecuting, and maintaining
      Licensed Patents, including foreign filings and Patent Cooperation Treaty
      filings. LICENSEE shall, at its own expense, perform all actions and
      execute or cause to be executed all documents necessary to support such
      filing, prosecution, or maintenance.

10.2  MICHIGAN shall notify LICENSEE of all information received by MICHIGAN
      relating to the filing, prosecution and maintenance of Licensed Patents,
      including any lapse, revocation, surrender, invalidation or abandonment of
      any of the Licensed Patents, in

                                       11
<PAGE>

      sufficient time to allow, where possible, LICENSEE to review and comment
      upon such information.

10.3  MICHIGAN may in its sole discretion decide to refrain from or to cease
      prosecuting or maintaining any of the Licensed Patents, including any
      foreign filing or any Patent Cooperation Treaty filing. If MICHIGAN makes
      any such decision, MICHIGAN shall notify LICENSEE promptly and in
      sufficient time to permit LICENSEE at its sole discretion to continue such
      prosecution or maintenance at LICENSEE's expense. If LICENSEE elects to
      continue such prosecution or maintenance, MICHIGAN shall execute such
      documents and perform such acts at LICENSEE's expense as may be reasonably
      necessary for LICENSEE so to continue such prosecution or maintenance.

10.4  LICENSEE shall reimburse patent expenses paid by MICHIGAN as follows:
      MICHIGAN shall provide notice to LICENSEE of all reasonable and necessary
      expenses paid by MICHIGAN in monitoring, drafting, filing, prosecuting and
      maintaining the Licensed Patents, and in maintaining or asserting its
      inventorship or ownership interest in Licensed Patent(s), including
      without limitation fees paid to outside counsel or consultants; patent
      office fees for filing, prosecution, reissue, reexamination and issue;
      maintenance fees; fees for foreign filings and Patent Cooperation Treaty
      filings; and reasonable travel expenses incurred by MICHIGAN employees for
      the purpose of monitoring, prosecuting and maintaining the Licensed
      Patents, but not including any part of any MICHIGAN employee's salary.
      MICHIGAN will include in the first such notice of such expenses all
      expenses that MICHIGAN has incurred to date with respect to all Licensed
      Patents that LICENSEE has not otherwise already reimbursed. Within thirty
      (30) days of the receipt of each such notice, LICENSEE shall reimburse
      MICHIGAN for all such reasonable and necessary expenses, except that
      MICHIGAN will not require LICENSEE to reimburse expenses incurred through
      foreign filings or Patent Cooperation Treaty filings, unless LICENSEE has
      requested such filings; however, in any case where LICENSEE fails to
      reimburse MICHIGAN promptly for any above-described expenses (whether or
      not related to filings requested by LICENSEE), the definitions of
      "TECHNOLOGY" and "Licensed Patents" herein shall not include any patent
      applications or resulting patents to which such unreimbursed expenses
      relate.

11.   INFRINGEMENT.

11.1  LICENSEE and MICHIGAN shall each inform the other promptly in writing of
      any alleged infringement of the Licensed Patents in any Field of Use by a
      third party and of any available evidence thereof.

11.2  During the term of this Agreement, LICENSEE has the first option to police
      the Licensed Patents and Products against infringement by other parties
      within the Territory and the Fields of Use. This right to police includes
      defending any action for declaratory judgment of non-infringement or
      invalidity; and prosecuting, defending or settling all infringement and
      declaratory judgment actions at its expense and through counsel of its
      selection, except that LICENSEE shall make any such settlement only with
      the advice and consent of MICHIGAN, which consent shall not be
      unreasonably withheld. MICHIGAN shall provide reasonable assistance to
      LICENSEE with respect to such

                                       12
<PAGE>

      actions, but only if LICENSEE reimburses MICHIGAN for out-of-pocket
      expenses incurred in connection with any such assistance rendered at
      LICENSEE's request or reasonably required by MICHIGAN. If LICENSEE elects
      to institute any such action or suit, MICHIGAN agrees to be named as a
      nominal party therein. MICHIGAN retains the right to participate, with
      counsel of its own choosing and at its own expense, in any action under
      this Paragraph 11.2.

11.3  If LICENSEE institutes an action for infringement of a Licensed Patent or
      defends a declaratory judgment or other action with respect to a Licensed
      Patent, then during the pendency of such litigation LICENSEE may withhold
      up to fifty percent (50%) of the payments otherwise thereafter due
      MICHIGAN under Paragraphs 4.2 and 4.3 above, applying that withholding
      towards reimbursement of no more than one-half (1/2) of LICENSEE's actual
      outside attorney fees and other direct, out-of-pocket litigation expenses
      (not to include any compensation paid to employees of LICENSEE or
      Affiliates). Any resulting settlement payments or damages awarded and
      received by LICENSEE shall be applied equally toward reimbursement of
      MICHIGAN's withheld royalties pursuant to this Paragraph and to LICENSEE's
      out-of-pocket expenses which were not reimbursed; of the remainder, if
      any, LICENSEE shall pay forty percent (40%) to MICHIGAN.

      If LICENSEE has paid or pays an annual fee to MICHIGAN under Paragraph 4.5
      in the same year LICENSEE receives a payment or award as set out above,
      then LICENSEE may credit that annual fee against the share of the payment
      or award (after recovery of expenses and withheld royalties) otherwise due
      to MICHIGAN, exactly as if that share represented additional royalties due
      from LICENSEE.

11.4  If LICENSEE fails to take action to abate any alleged infringement of a
      Licensed Patent within sixty (60) days of a request by MICHIGAN to do so
      (or within a shorter period if required to preserve the legal rights of
      MICHIGAN under the laws of any relevant government or political
      subdivision thereof), then MICHIGAN has the right to take such action
      (including prosecution of a suit) at its expense and LICENSEE shall use
      reasonable efforts to cooperate in such action, at LICENSEE's expense. If
      MICHIGAN elects to institute any such action or suit, LICENSEE agrees to
      be named as a nominal party therein. MICHIGAN has full authority to settle
      on such terms as MICHIGAN shall determine, except that MICHIGAN shall not
      reach any settlement whereby it licenses a third party under any Licensed
      Patents in the Territory and any Field of Use without the consent of
      LICENSEE, which consent LICENSEE can withhold for any reason. After
      recovery of all of MICHIGAN's out-of-pocket litigation expenses, and after
      payment to LICENSEE (such payment not to exceed the recovery or settlement
      amounts actually received by MICHIGAN) of any unrecovered expenses paid by
      LICENSEE at MICHIGAN's request to third parties in furtherance of such
      action, MICHIGAN shall pay twenty percent (20%) of any remainder of any
      recovery or settlement to LICENSEE.

11.5  If LICENSEE initiates any legal action, or learns of a legal action
      initiated by any third party concerning any alleged infringement or
      non-infringement, or discovers any allegation by a third party of
      infringement resulting from the practice of Licensed Patents, then
      LICENSEE shall so notify MICHIGAN promptly in a detailed writing. LICENSEE

                                       13
<PAGE>

      shall promptly keep MICHIGAN informed and provide copies to MICHIGAN of
      all documents regarding all such proceedings or actions instituted by
      LICENSEE.

12.   NO WARRANTIES; LIMITATION ON MICHIGAN'S LIABILITY.

12.1  MICHIGAN, including its Regents, fellows, officers, employees and agents,
      make no representations or warranties that any Licensed Patent is or will
      be held valid, or that the manufacture, use, sale or other distribution of
      any Products will not infringe upon any patent or other rights not vested
      in MICHIGAN.

      MICHIGAN represents that:

      (1)  to its knowledge it has the lawful right to enter into this Agreement
           and grant the rights herein granted; and

      (2)  the claims included within the patent applications which comprise the
           Licensed Patents have been included in good faith and without
           fraudulent intent by MICHIGAN.

12.2  MICHIGAN, INCLUDING ITS REGENTS, FELLOWS, OFFICERS, EMPLOYEES AND AGENTS,
      MAKES NO REPRESENTATIONS, EXTENDS NO WARRANTIES OF ANY KIND, EITHER
      EXPRESS OR IMPLIED, INCLUDING BUT NOT LIMITED TO THE IMPLIED WARRANTIES OF
      MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, AND ASSUMES NO
      RESPONSIBILITIES WHATEVER WITH RESPECT TO DESIGN, DEVELOPMENT,
      MANUFACTURE, USE, SALE OR OTHER DISPOSITION BY LICENSEE, AFFILIATES OR
      SUBLICENSEES OF PRODUCTS.

12.3  THE ENTIRE RISK AS TO PERFORMANCE OF PRODUCTS IS ASSUMED BY LICENSEE,
      AFFILIATES AND SUBLICENSEES. In no event will MICHIGAN, including its
      Regents, fellows, officers, employees and agents, be responsible or liable
      for any direct, indirect, special, incidental, or consequential damages or
      lost profits or other economic loss or damage regarding Products, to
      LICENSEE, Affiliates, Sublicensees or any other individual or entity
      regardless of legal theory. The above limitations on liability apply even
      though MICHIGAN, its Regents, fellows, officers, employees or agents may
      have been advised of the possibility of such damage.

12.4  LICENSEE shall not, and shall require that its Affiliates and Sublicensees
      do not, make any statements, representations or warranties whatsoever to
      any person or entity, or accept any liabilities or responsibilities
      whatsoever from any person or entity, that are inconsistent with any
      disclaimer or limitation included in this Article 12.

13.   INDEMNITY; INSURANCE.

13.1  LICENSEE shall defend, indemnify and hold harmless and shall require its
      Affiliates and Sublicensees to defend, indemnify and hold harmless
      MICHIGAN, its Regents, fellows, officers, employees and agents
      ("Indemnitees"), for and against any claims, demands, damages, losses, and
      expenses of any nature (including reasonable attorneys, fees and

                                       14
<PAGE>

      other litigation expenses), resulting from, but not limited to, death,
      personal injury, illness, property damage, economic loss or products
      liability arising from any of the following:

      (1)  Any manufacture, use, sale or other disposition by LICENSEE,
           Affiliates, Sublicensees or transferees of Products;

      (2)  The direct or indirect use by any person of Products made, used, sold
           or otherwise distributed by LICENSEE, Affiliates or Sublicensees;

      (3)  The use by LICENSEE, Affiliates or Sublicensees of any invention or
           computer software related to the TECHNOLOGY or the Licensed Patents.

      The indemnification required above shall not apply to any liability,
      damage, loss or expense to the extent that it is directly attributable to
      (1) the grossly negligent or intentional misconduct of the Indemnitees, or
      (2) damages incurred by patients of MICHIGAN due to the negligent
      administration to them, by MICHIGAN, of Products supplied by LICENSEE.

13.2  MICHIGAN may participate at its option and expense through counsel of its
      own selection, and may join in any legal actions related to any such
      claims, demands, damages, losses and expenses under Paragraph 13.1 above.

13.3  Before any distribution of any Product by LICENSEE or an Affiliate,
      LICENSEE shall purchase and maintain in effect a policy of product
      liability insurance. Before any distribution of any Product by a
      Sublicensee, LICENSEE shall require that the Sublicensee purchase and
      maintain in effect a policy of product liability insurance. Each such
      insurance policy will provide reasonable coverage for all claims with
      respect to any Products manufactured, sold, licensed or otherwise
      distributed by LICENSEE and Affiliates -- or, in the case of a
      Sublicensee's policy, by the Sublicensee -- and will specify MICHIGAN,
      including its Regents, fellows, officers and employees, as an additional
      insured. LICENSEE shall furnish certificate(s) of such insurance to
      MICHIGAN, upon request.

14.   TERM AND TERMINATION.

14.1  Upon any termination of this Agreement, and except as provided herein to
      the contrary, all rights and obligations of the Parties hereunder cease,
      except as follows:

      (1)  Obligations to pay royalties and other sums accruing hereunder up to
           the day of such termination;

      (2)  MICHIGAN's rights to inspect books and records as described in
           Article 5, and LICENSEE's obligations to keep such records for the
           required time;

      (3)  Obligations to hold harmless, defend and indemnify MICHIGAN under
           Article 13;

                                       15
<PAGE>

      (4)  Any cause of action or claim of LICENSEE or MICHIGAN accrued or to
           accrue because of any breach or default by the other Party hereunder;

      (5)  The general rights, obligations, and understandings of Articles 2,
           12, 17, 19, 20, 28 and 29; and

      (6)  All other terms, provisions, representations, rights and obligations
           contained in this Agreement that by their sense and context are
           intended to survive until performance thereof by either or both
           Parties.

14.2  This Agreement will become effective on its Effective Date and, unless
      terminated under another, specific provision of this Agreement, will
      remain in effect until and terminate upon the last to expire of the
      Licensed Patents.

14.3  If LICENSEE at any time defaults in the payment of any fee or royalty or
      the making of any report hereunder, or makes any false report, or if
      either Party commits any material breach of any covenant or promise herein
      contained, and fails to remedy any such default, breach or report within
      thirty (30) days after written notice thereof by the other Party
      specifying such default, then that other Party may, at its option,
      terminate this Agreement and the license rights granted herein by notice
      in writing to such effect. Any such termination is without prejudice to
      either Party's other legal rights for breach of this Agreement.

14.4  LICENSEE may terminate this Agreement by giving MICHIGAN a notice of
      termination, which must include a statement of the reasons, whatever they
      may be, for such termination and the termination date established by
      LICENSEE, which date must not be sooner than ninety (90) days after the
      date of the notice. The Parties shall deem such notice to be final and,
      immediately upon receipt, of such notice of termination, MICHIGAN will
      have the right to enter into agreements with others for the manufacture,
      sale, and/or use of Products.

15.   ASSIGNMENT.

      Due to the unique relationship between the Parties, this Agreement is not
      assignable by either Party without the prior written consent of the other
      Party. Any attempt to assign this Agreement without such consent is void
      from the beginning. MICHIGAN shall provide such consent in connection with
      an assignment related to a change in the name or legal status of LICENSEE
      that does not affect its assets and the nature of its business activities,
      and MICHIGAN shal1 not unreasonably withhold consent for LICENSEE to
      assign this Agreement to a purchaser of all or substantially all of
      LICENSEE's business. No assignment is effective until the intended
      assignee agrees in writing to accept all the terms and conditions of this
      Agreement.

16.   REGISTRATION AND RECORDATION.

16.1  If the terms of this Agreement, or the terms of any assignment or license
      under this Agreement, are or become such as to require that the Agreement
      or license or any part thereof be registered with or reported to a
      national or supranational agency of any area in

                                       16
<PAGE>

      which LICENSEE, Affiliates or Sublicensees would do business, LICENSEE
      shall, at its expense, undertake such registration or report, and promptly
      supply to MICHIGAN notice and appropriate verification of the act of
      registration or report or any agency ruling resulting from it.

16.2  LICENSEE shall also carry out, at its expense, any formal recordation of
      this Agreement or any license herein granted that the law of any country
      requires as a prerequisite to enforceability of the Agreement or license
      in the courts of any such country or for other reasons, and shall promptly
      furnish to MICHIGAN appropriately verified proof of recordation.

17.   LAWS AND REGULATIONS OF THE UNITED STATES; EXPORT.

17.1  This Agreement is subject to all United States laws and regulations now or
      hereafter applicable to the subject matter of this Agreement.

17.2  LICENSEE shall comply, and shall require its Affiliates and Sublicensees
      to comply, with all provisions of any applicable laws, regulations, rules
      and orders relating to the license herein granted and to the testing,
      production, transportation, export, packaging, labeling, sale or use of
      Products, or otherwise applicable to LICENSEE's or its Affiliates' or
      Sublicensees' activities hereunder. LICENSEE shall obtain, and shall
      require its Affiliates and Sublicensees to obtain, such written assurances
      regarding export and re-export of technical data (including Products made
      by use of technical data) as the Office of Export Administration
      Regulations may require, and LICENSEE hereby gives such written assurances
      as may be required under those Regulations to MICHIGAN.

18.   BANKRUPTCY.

18.1  If during the term of this Agreement, LICENSEE makes an assignment for the
      benefit of creditors, or if proceedings in voluntary or involuntary
      bankruptcy are instituted on behalf of or against LICENSEE, or if a
      receiver or trustee is appointed for the property of LICENSEE, MICHIGAN
      may, at its option, terminate this Agreement and revoke the license herein
      granted by written notice to LICENSEE.

19.   USE OF MICHIGAN'S NAME.

      LICENSEE agrees to refrain from using and to require Affiliates and
      Sublicensees to refrain from using the name of MICHIGAN in publicity or
      advertising without the prior written approval of MICHIGAN. Reports in
      scientific literature and presentations of joint research and development
      work are not considered publicity.

20.   PRODUCT MARKING.

      To the extent commercially feasible and consistent with prevailing
      business practices, LICENSEE shall mark, and shall cause its Affiliates
      and Sublicensees to mark, all Products that are manufactured or sold under
      this Agreement with the number of each issued patent under the Licensed
      Patents that applies to such Product.

                                       17
<PAGE>

21.   NOTICES.

      Any notice, request, report or payment required or permitted to be given
      or made under this Agreement by either Party will be given by sending such
      notice by certified or registered mail, return receipt requested, to the
      address set forth below or such other address as such Party specifies by
      written notice given in conformity herewith. Any notice not so given is
      not valid until received, and any notice given according to the provisions
      of this Paragraph is effective when mailed.

      To MICHIGAN:        The University of Michigan
                          Technology Management Office
                          Wolverine Tower, Room 2071
                          3003 S. State Street
                          Ann Arbor, MI 48109-1280
                          Attn:  File No. 1221

      To LICENSEE:        Reprogenesis, Inc.
                          10 Sylvan Drive, Suite 27
                          St. Simons Island, Georgia 31522

22.   INVALIDITY.

      If a court of competent jurisdiction finds any term, provision, or
      covenant of this Agreement invalid, illegal or unenforceable, that term
      will be curtailed, limited or deleted, but only to the extent necessary to
      remove the invalidity, illegality or unenforceability, and without in any
      way affecting or impairing the remaining terms, provisions and covenants.

23.   ENTIRE AGREEMENT AND AMENDMENTS.

      This Agreement contains the entire understanding of the Parties concerning
      the matter contained herein. The Parties may modify, vary or alter any of
      the provisions of this Agreement for so long as it continues in force, but
      only by an instrument duly executed by authorized officials of both
      Parties hereto.

24.   WAIVER.

      No waiver by either Party of any breach of this Agreement, no matter how
      long continuing or how often repeated, is a waiver of any subsequent
      breach thereof, nor is any delay or omission by either Party in the
      exercise of any right, power, or privilege hereunder a waiver of such
      right, power or privilege.

25.   ARTICLE HEADINGS.

      The Article headings herein are for purposes of convenient reference only
      and do not define or modify the terms written in the text of this
      Agreement.

                                       18
<PAGE>

26.   NO AGENCY RELATIONSHIP.

      The relationship between the Parties is that of independent contractor and
      contractee. Neither Party is an agent of the other regarding the exercise
      of any rights hereunder, and neither has any right or authority to assume
      or create any obligation or responsibility on behalf of the other.

27.   FORCE MAJEURE.

      Neither Party hereto is in default of any provision of this Agreement for
      any failure in performance resulting from acts or events beyond the
      reasonable control of such Party, such as Acts of God, acts of civil or
      military authority, civil disturbance, war, strikes, fires, power
      failures, natural catastrophes or other "force majeure" events.

28.   GOVERNING LAW.

      The law of the State of Michigan governs this Agreement and the
      relationships between the Parties in all respects (notwithstanding any
      provisions governing conflict of laws under such Michigan law to the
      contrary), except that, for patents, the law of the country that grants
      the patent determines questions affecting the construction and effect of
      such patent.

29.   JURISDICTION AND FORUM.

      The Parties hereby consent to the jurisdiction of the courts of the State
      of Michigan over any dispute concerning this Agreement or the relationship
      between the Parties. Should LICENSEE bring any claim, demand or other
      action against MICHIGAN, its Regents, fellows, officers, employees or
      agents, arising out of this Agreement or the relationship between the
      Parties, LICENSEE agrees to bring said action only in the Michigan Court
      of Claims.

30.   CONFIDENTIALITY.

30.1  Confidential Information that is disclosed in writing shall be marked with
      a legend indicating its confidential status (such as "Confidential" or
      "Proprietary"). Confidential Information that is disclosed orally or
      visually shall be documented in a written notice prepared by the
      Disclosing Party and delivered to the Receiving Party within thirty (30)
      days of the date of disclosure; such notice shall summarize the
      Confidential Information disclosed to the Receiving Party and reference
      the time and place of disclosure.

30.2  For a period of five (5) years after disclosure of any portion of
      Confidential Information, the Receiving Party shall (i) maintain such
      Confidential Information in confidence, except that the Receiving Party
      may disclose or permit the disclosure of any Confidential Information to
      its Regents, fellows, directors, officers, employees, consultants and
      advisors who are obligated to maintain the confidential nature of such
      Confidential Information and who need to know such Confidential
      Information for the purposes of this Agreement; (ii) use such Confidential
      Information solely for the purposes of this Agreement (and for
      administration of this Agreement and demonstration of compliance

                                       19
<PAGE>

      or lack thereof with the terms herein); (iii) allow its Regents, fellows,
      directors, officers, employees, consultants and advisors to reproduce the
      Confidential Information only to the extent necessary for the
      above-mentioned purposes, with all such reproductions being considered
      Confidential Information.

30.3  The obligations of the Receiving Party under Paragraph 30.2 shall not
      apply to the extent that the Receiving Party can demonstrate that certain
      Confidential Information (i) was in the public domain prior to the time of
      its disclosure under this Agreement; (ii) entered the public domain after
      the time of its disclosure under this Agreement through means other than
      an unauthorized disclosure resulting from an act or omission by the
      Receiving Party; (iii) was independently developed or discovered by the
      Receiving Party without use of the Confidential Information; (iv) is or
      was disclosed to the Receiving Party at any time, whether prior to or
      after the time of its disclosure under this Agreement, by a third party
      having no fiduciary relationship with the Disclosing Party and having no
      obligation of confidentiality with respect to such Confidential
      Information; or (v) is required to be disclosed to comply with applicable
      laws or regulations (including Michigan Freedom of Information Act
      requirements), or with a court or administrative order, provided that the
      Disclosing Party provides reasonable prior written notice of such
      disclosure to the extent possible.

30.4  The Receiving Party acknowledges that the Disclosing Party (or any third
      party entrusting its own information to the Disclosing Party) claims
      ownership of its Confidential Information in the possession of the
      Receiving Party. Upon the expiration or termination of this Agreement, and
      at the request of the Disclosing Party, the Receiving Party shall return
      to the Disclosing Party all originals, copies, and summaries of documents,
      materials, and other tangible manifestations of Confidential Information
      in the possession or control of the Receiving Party, except that the
      Receiving Party may retain one copy of the Confidential Information in the
      possession of its legal counsel solely for the purposes of monitoring all
      of its and the other Party's obligations under this Agreement.

IN WITNESS WHEREOF, the Parties hereto have executed this Agreement in duplicate
originals by their duly authorized officers or representatives.

                                         FOR THE REGENTS OF THE UNIVERSITY OF
FOR REPROGENESIS, INC.                   MICHIGAN

By   /s/                                 By   /s/
  -----------------------------------      ------------------------------------
    (authorized representative)              (authorized representative)

Typed Name____________________________   Typed Name____________________________

Title_________________________________   Title_________________________________

Date__________________________________   Date__________________________________

                                       20
<PAGE>

     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                                   APPENDIX A

                   Licensed Patents Filed as of Effective Date

1.    U.S. Provisional Patent Application Serial No. [**], filed [**], entitled
      [**], David Mooney, Letrese Harris and Lonnie Shea, named inventors, and
      assigned to the Regents of the University of Michigan.

2.    Patent Cooperation Treaty Application Serial No. [**], filed [**],
      designating all PCT member countries including the United States, entitled
      [**], David Mooney and Jon Rowley, named inventors, the Regents of the
      University of Michigan, applicant.

                                       21
<PAGE>

     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

                         AMENDMENT TO LICENSE AGREEMENT

THIS AMENDMENT, effective as of the 1st day of August, 1999 (the EFFECTIVE
DATE), between Reprogenesis, Inc., a corporation incorporated in the State of
Texas, with offices located at 10 Sylvan Drive, Suite 27, St. Simons Island,
Georgia 31522 ("LICENSEE") and the Regents of the University of Michigan, a
constitutional corporation of the State of Michigan, with offices located at
3003 South State, Room 2071, Ann Arbor, Michigan 48109-1280 ("MICHIGAN").
LICENSEE and MICHIGAN agree as follows:

1.    BACKGROUND

      1.1   MICHIGAN and LICENSEE entered into a LICENSE AGREEMENT dated
            November 30, 1997 covering certain TECHNOLOGY and LICENSED PATENTS
            as therein defined.

      1.2   MICHIGAN and LICENSEE entered into a ROUNDTABLE RESEARCH AGREEMENT
            dated October 1, 1997. Pursuant to Article 8.1 therein, LICENSEE
            timely exercised its option to negotiate for an exclusive,
            royalty-bearing license to certain rights in University Intellectual
            Property as defined in the ROUNDTABLE RESEARCH AGREEMENT.

      1.3   MICHIGAN has developed ADDITIONAL TECHNOLOGY comprising methods and
            means for delivering DNA from certain structural matrices developed
            by MICHIGAN's staff members Drs. D. Mooney, L. Shea and J. Bonadio,
            as described in Michigan's Technology Management Office File #[**]
            entitled [**] (hereinafter defined as "ADDITIONAL TECHNOLOGY").
            MICHIGAN acknowledges that ADDITIONAL TECHNOLOGY is within the
            definition of University Intellectual Property. The ADDITIONAL
            TECHNOLOGY is now the subject of an additional United States patent
            application serial number [**] filed on [**] and a counterpart
            Patent Cooperation Treaty application filed on even date
            (hereinafter these and all other patent applications and patents
            which cover an invention included in the ADDITIONAL TECHNOLOGY are
            defined as "ADDITIONAL LICENSED PATENTS").

      1.4   LICENSEE desires to obtain, and MICHIGAN, consistent with its
            mission of education and research, desires to grant, a license to
            the ADDITIONAL TECHNOLOGY and ADDITIONAL LICENSED PATENTS pursuant
            to the aforementioned LICENSE AGREEMENT. To this end, and for the
            benefit of both parties, MICHIGAN and LICENSEE agree to amend the
            LICENSE AGREEMENT.

2.    AMENDMENT

      The term TECHNOLOGY includes the ADDITIONAL TECHNOLOGY, and the term
      LICENSED PATENTS includes the ADDITIONAL LICENSED PATENTS. Solely with
      respect to ADDITIONAL TECHNOLOGY and ADDITIONAL LICENSED PATENTS,
      MICHIGAN's covenant under Paragraph 3.1 (LICENSE AGREEMENT) is limited as
      follows:
<PAGE>

     Confidential materials omitted and filed separately with the Securities
              and Exchange Commission. Asterisks denote omissions.

      LICENSEE acknowledges, and agrees that all sublicenses of LICENSEE to
      Affiliates and Sublicensees must include an acknowledgement by such
      Affiliate or Sublicensee; that the non-infringing practice of ADDITIONAL
      TECHNOLOGY and ADDITIONAL LICENSED PATENTS may require a license to
      certain background rights of MICHIGAN licensed by MICHIGAN to [**].

3.    ENTIRE AGREEMENT

      The terms and conditions of the LICENSE AGREEMENT shall remain in full
      force and effect, except as amended herein.

IN WITNESS WHEREOF, the PARTIES hereto have executed this Amendment in duplicate
originals by their duly authorized officers or representatives.

FOR REPROGENESIS, INC.
                                         FOR THE REGENTS OF THE UNIVERSITY
                                         OF MICHIGAN

By:  /s/ Daniel R. Omstead               By:  /s/ Michael A. Kope
    ---------------------------               -------------------------------
    (authorized representative)               (authorized representative)
Typed Name: Daniel R. Omstead            Typed Name: Michael A. Kope
Title:  President                        Title:  Assistant to the Director
Date: ________________________           Date:  Aug. 11, 1999

                                       23

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