Document:

<PAGE>

                                                                  Exhibit 10.4.1

     THIS FIRST AMENDMENT TO PURCHASE AGREEMENT (this "Amendment") is made and
entered into this 28th day of April, 2003, by and between VENTAS REALTY, LIMITED
PARTNERSHIP, a Delaware limited partnership ("Buyer") and TRANS HEALTHCARE OF
OHIO, INC., a Delaware corporation ("Seller") and shall be deemed effective as
of November 1, 2002 (the "Effective Date").

                                    RECITALS

     WHEREAS, Seller and Ventas previously entered into that certain Purchase
and Sale Agreement dated as of November 1, 2002 (the "Purchase Agreement")
pursuant to which Buyer purchased the Property from Seller; and

     WHEREAS, at the request of Seller, the parties desire to amend the Purchase
Agreement on the terms hereinafter set forth;

     NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are acknowledged hereby, the parties hereto agree to
incorporate the foregoing recitals as if the same were more particularly set
forth in the body of this Agreement and further agree as follows:

     1.   Amendment to Purchase Agreement. Effective as of the Effective Date,
Exhibit C (Allocated Purchase Price) attached to the Purchase Agreement is
hereby deleted in its entirety and replaced with the attached Exhibit C
(Allocated Purchase Price).

     2.   Amendment Controlling. This Amendment is considered by the parties to
the Purchase Agreement to be an integral part of such Purchase Agreement. If
there is any conflict between the terms of the Purchase Agreement and this
Amendment, the terms of this Amendment shall control. Except as expressly
amended herein, all other terms, agreements, and conditions of the Purchase
Agreement shall remain unmodified and in full force and effect.

     3.   Counterparts/Fax Signatures. This Amendment may be executed in two or
more counterparts, any one of which need not contain the signatures of more than
one party, but all such counterparts when taken together will constitute one in
the same agreement. Confirmation of the execution of this Agreement by telex or
by telecopy or telefax of a facsimile page(s) executed by the parties shall be
binding upon the parties hereto.

                           [Signature Page to Follow]

<PAGE>

     IN WITNESS WHEREOF, the parties hereto have executed this First Amendment
to Purchase and Sale Agreement on the date first above written.

                                      SELLER:

                                      TRANS HEALTHCARE OF OHIO, INC., a
                                      Delaware corporation

                                      By:  /s/ Jeffrey A. Barnhill
                                           -----------------------
                                      Its: Senior Vice President
                                           ---------------------

                                      BUYER:

                                      VENTAS REALTY, LIMITED
                                      PARTNERSHIP, a Delaware corporation

                                      By:   Ventas, Inc., a Delaware corporation
                                      Its:  General Partner

                                            By:  /s/ T. Richard Riney
                                                 --------------------
                                            Its: Executive Vice President and
                                                 ----------------------------
                                                 General Counsel
                                                 ---------------

                                        2

<PAGE>

                                    EXHIBIT C

                            Allocated Purchase Price

<TABLE>
<CAPTION>
                                                             BUILDING AND            TOTAL
                                                             ------------            -----
              FACILITY                   LAND                   OTHER            PURCHASE PRICE
              --------                   ----                   -----            --------------
<S>                                 <C>                     <C>                  <C>
1.   Chardon Quality Care           $  210,000.00           $ 6,614,000.00       $ 6,824,000.00

2    Greenbriar Hospital            $   90,000.00           $ 3,332,000.00       $ 3,422,000.00

3.   Greenbriar Quality Care        $  380,000.00           $ 8,958,000.00       $ 9,338,000.00

4.   The Commons at Greenbriar      $  210,000.00           $ 2,106,000.00       $ 2,316,000.00

5.   South River                    $  580,000.00           $ 7,120,000.00       $ 7,700,000.00

6.   Regency Nursing                $  640,000.00           $10,560,000.00       $11,200,000.00

7.   St. Agnes                      $  830,000.00           $11,370,000.00       $12,200,000.00
                                    -------------           --------------       --------------
Total:                              $2,940,000.00           $50,060,000.00       $53,000,000.00
                                    =============           ==============       ==============
</TABLE><PAGE>

                                                                  Exhibit 10.4.2

     THIS FIRST AMENDMENT TO GUARANTY (this "Amendment") is made and entered
into this 28th day of April, 2003, by and between VENTAS REALTY, LIMITED
PARTNERSHIP, a Delaware limited partnership (together with its successors and
assigns, the "Lender") and TRANS HEALTHCARE, INC., a Delaware corporation
("Parent"), and the subsidiaries of Parent listed on Schedule A hereto (along
with Parent, each a "Guarantor" and collectively, the "Guarantors") and shall be
deemed effective as of November 1, 2002 (the "Effective Date").

                                    RECITALS

     WHEREAS, Guarantors previously executed that certain Guaranty dated as of
November 1, 2002 for the benefit of Lender (the "Guaranty");

     WHEREAS, at the request of Guarantor, the parties desire to amend the
Guaranty on the terms hereinafter set forth;

     NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are acknowledged hereby, the parties hereto agree to
incorporate the foregoing recitals as if the same were more particularly set
forth in the body of this Agreement and further agree as follows:

     1. Replacement of Schedule 2. Effective as of the Effective Date, Section
6.3 of the Guaranty (Minimum Consolidated Net Worth) is hereby deleted in its
entirety and replaced with the following Section 6.3 (Minimum Consolidated Net
Worth):

          Section 6.3. Minimum Consolidated Net Worth. The Consolidated Net
     Worth of Parent and its Consolidated Subsidiaries will not be less than
     $34,000,000 for each Fiscal Quarter ending in Fiscal Years 2002 and 2003,
     $47,000,000 for each Fiscal Quarter in Fiscal Year 2004 and $62,000,000 for
     each Fiscal Quarter in Fiscal Year 2005 and thereafter, in each case plus
     (a) the amount of any gain associated with the Sale/Leaseback Transaction
     plus (b) 90% of any proceeds (without duplication) received by Parent or
     any of its Consolidated Subsidiaries pursuant to the issuance of any equity
     securities of such entities.

     2. Amendment Fee. In consideration of this Amendment, Guarantor hereby
agrees to pay to Lender a nonrefundable fee in the amount of $50,000 to be wired
to Lender within two (2) business days after the execution and delivery of this
Amendment by the parties ("Payment Date"). In the event that Lender does not
receive such fee by the Payment Date, this Amendment shall be void and of no
further force or effect.

     3. No Default. Guarantor hereby represents and warrants to Lender that no
condition exists that constitutes a default under the Guaranty or would with the
giving of notice or the passage of time constitute a default under the Guaranty.

     4. Amendment Controlling. This Amendment is considered by to be an integral
part of the Guaranty. If there is any conflict between the terms of the Guaranty
and this Amendment, the terms of this Amendment shall control. Except as
expressly amended herein,

<PAGE>

all other terms, agreements, and conditions of the Guaranty shall remain
unmodified and in full force and effect.

     5. Counterparts/Fax Signatures. This Amendment may be executed in two or
more counterparts, any one of which need not contain the signatures of more than
one party, but all such counterparts when taken together will constitute one in
the same agreement. Confirmation of the execution of this Agreement by telex or
by telecopy or telefax of a facsimile page(s) executed by the parties shall be
binding upon the parties hereto.

                           [Signature Page to Follow]

<PAGE>

     IN WITNESS WHEREOF, the parties have caused this First Amendment to
Guaranty to be executed as of the date first above written.

                           LENDER:

                           VENTAS REALTY, LIMITED PARTNERSHIP, a Delaware
                           limited partnership

                               By:   Ventas, Inc., a Delaware corporation

                                     By:  /s/ T. Richard Riney
                                         ------------------------------
                                     Name:  T. Richard Riney
                                           ----------------------------
                                     Title: Executive Vice President
                                            ---------------------------
                                            and General Counsel
                                            ---------------------------

                           GUARANTOR:

                           TRANS HEALTHCARE, INC.,
                           a Delaware corporation

                           By:  /s/ Anthony F. Misitano
                               ------------------------------
                               Name:  Anthony F. Misitano
                               Title: President

                           TRANS HEALTHCARE OF OHIO, INC.,
                           a Delaware corporation

                           By:  /s/ Anthony F. Misitano
                               ------------------------------
                               Name:  Anthony F. Misitano
                               Title: President

                           THI OF OHIO ALFS, INC.,
                           a Delaware corporation

                           By:  /s/ Anthony F. Misitano
                               ------------------------------
                               Name:  Anthony F. Misitano
                               Title: President

<PAGE>

                           THI PROPERTIES, INC.,
                           a Delaware corporation

                           By: /s/ Anthony F. Misitano
                              -------------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           THI SERVICES CORP.,
                           a Delaware corporation

                           By: /s/ Anthony F. Misitano
                              -------------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           THI SPECIALTY HOSPITALS OF OHIO, INC.,
                           a Delaware corporation

                           By: /s/ Anthony F. Misitano
                              -------------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           TRANS HEALTH MANAGEMENT, INC.,
                           a Delaware corporation

                           By: /s/ Anthony F. Misitano
                              -------------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           THI OF MARYLAND, INC.,
                           a Delaware corporation

                           By: /s/ Anthony F. Misitano
                              -------------------------------
                              Name:  Anthony F. Misitano
                              Title: President

<PAGE>

                           PHYSICAL THERAPY PLUS, INC.,
                           a Pennsylvania corporation

                           By: /s/ Anthony F. Misitano
                              ------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           DALE J. CORDIAL, PT, INC.,
                           a Pennsylvania corporation

                           By: /s/ Anthony F. Misitano
                              ------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           DALE J. CORDIAL, PT, INC., NUMBER 4,
                           a Pennsylvania corporation

                           By: /s/ Anthony F. Misitano
                              ------------------------
                              Name:  Anthony F. Misitano
                              Title: President

                           THE PT GROUP OF PENN HILLS,
                           a Pennsylvania general partnership

                           By: Trans Healthcare, Inc.,
                               a Delaware corporation,
                               its Partner

                               By: /s/ Anthony F. Misitano
                                  ------------------------
                                  Name: Anthony F. Misitano
                                  Title: President

<PAGE>

                           THE PT GROUP PHYSICAL THERAPY FOR WOMEN,
                           a Pennsylvania general partnership

                           By: Dale J. Cordial, PT, Inc.,
                               a Pennsylvania corporation,
                               its Partner

                               By: /s/ Anthony F. Misitano
                                  ------------------------
                                  Name:  Anthony F. Misitano
                                  Title: President

                           THE PT GROUP OF MOON TOWNSHIP,
                           a Pennsylvania general partnership

                           By: Dale J. Cordial, PT, Inc., Number 4,
                               a Pennsylvania corporation,
                               its Partner

                               By: /s/ Anthony F. Misitano
                                  ------------------------
                                  Name:  Anthony F. Misitano
                                  Title: President

                           THI Therapy Concepts, LLC,
                           a Delaware limited liability company

                           By: /s/ Jeffrey A. Barnhill
                              ------------------------
                              Name:  Jeffrey A. Barnhill
                              Title: Vice-President

                           THI SERVICES OF MARYLAND, LLC,
                           a Delaware limited liability company

                           By: /s/ Jeffrey A. Barnhill
                              ------------------------
                              Name:  Jeffrey A. Barnhill
                              Title: Vice-President

<PAGE>

                                   Schedule A
                          Parent Subsidiary Guarantors

1.  Trans Healthcare of Ohio, Inc.

2.  THI of Ohio ALFS, Inc.

3.  THI Properties, Inc.

4.  THI Services Corp.

5.  THI Specialty Hospitals of Ohio, Inc.

6.  Trans Health Management, Inc.

7.  THI of Maryland, Inc.

8.  THI Therapy Concepts, LLC

9.  THI Services of Maryland, LLC

10. Physical Therapy Plus, Inc.

11. The pt Group of Penn Hills

12. Dale J. Cordial, PT, Inc.

13. The pt Group Physical Therapy for Women

14. Dale J. Cordial, PT, Inc., Number 4

15. The pt Group of Moon Township

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