Document:

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                                                                    EXHIBIT 10.1
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                              ADOLOR CORPORATION
              Amended and Restated 1994 Equity Compensation Plan
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           Adolor Corporation, a Delaware corporation, wishes to attract
employees and consultants to the Company, to induce employees, Directors and
consultants to remain with the Company, to encourage them to increase their
efforts to make the Company's business more successful and to enhance
stockholder value. In furtherance thereof, the Adolor Amended and Restated 1994
Equity Compensation Plan is designed to provide incentive and non-qualified
stock options to employees, Directors and consultants of the Company.

1.   DEFINITIONS.
     -----------

           Whenever used herein and unless otherwise provided in the Optionee's
Grant Letter, the following terms shall have the meanings set forth below:

           "Administrator" means the Board, or a committee, the members of which
shall be appointed by the Board as described in Section 3.

           "Approved Sale" means the approval, prior to the consummation of a
Public Offering, by the holders of at least 50% of the Common Stock (including
voting and nonvoting shares voting as a single class) of (i) the merger or
consolidation of the Company, (ii) the sale of all or substantially all of its
assets or (iii) the sale of all or a majority of the outstanding capital stock
or my other similar transaction.

           "Board" means the Board of Directors of the Company.

           "Cause" means the Optionee's (i) conviction for committing a felony
under federal law or of the state in which such action occurred, (ii) dishonesty
in the course of fulfilling his or her employment duties or (iii) willful and
deliberate failure to perform his or her employment duties in any material
respect, or such other events as shall be determined by the Administrator.  The
Administrator shall have the sole discretion to determine whether "Cause"
exists, and its determination shall be final.

           "Change of Control" means the happening of any of the following after
the consummation of a Public Offering:

               (i)   any Person, other than (a) the Company or any of its
Subsidiaries, (b) a trustee or other fiduciary holding securities under an
employee benefit plan of the Company or any of its Subsidiaries, (c) an
underwriter temporarily holding securities pursuant to an offering of such
securities, (d) a corporation owned, directly or indirectly, by the stockholders
of the Company in substantially the same proportion as their ownership of stock
of the Company, or (e) an Optionee or any "group" (as such term is used in
Sections 13(d) and 14(d) of the Exchange Act) which includes the Optionee),
becomes the "beneficial owner" (as defined in Rule 13d-3 under the Exchange
Act), directly or indirectly, of securities of the Company (not including in the
securities beneficially owned by such Person any securities acquired directly
from the Company or its Subsidiaries) representing more than 25% of either the
then outstanding shares of
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Stock of the Company or the combined voting power of the Company's then
outstanding securities;

               (ii)  the individuals who serve on the Board as of the effective
date hereof (the "Incumbent Directors") cease for any reason to constitute at
least a majority of the Board; provided, however, any person who becomes a
director subsequent to the effective date hereof, whose election or nomination
for election was approved by a vote of at least a majority of the directors then
constituting the Incumbent Board, shall for purposes of this clause (ii) be
considered an Incumbent Director;

               (iii) the consummation of a merger or consolidation of the
Company in which the stockholders of the Company immediately prior to such
merger or consolidation, would not, immediately after the merger or
consolidation, beneficially own (as such term is defined in Rule 13d-3 under the
Exchange Act), directly or indirectly, shares representing in the aggregate 50%
or more of the combined voting power of the securities of the corporation
issuing cash or securities in the merger or consolidation (or of its ultimate
parent corporation, if any); or

               (iv)  the stockholders of the Company approve a plan of complete
liquidation or dissolution of the Company, or there is consummated an agreement
for the sale or disposition by the Company of all or substantially all of the
Company's assets, other than a sale or disposition by the Company of all or
substantially all of the Company's assets to an entity, at least 50% of the
combined voting power of the voting securities of which are owned by Persons in
substantially the same proportion as their ownership of the Company immediately
prior to such sale.

           "Code" means the Internal Revenue Code of 1986, as amended.

           "Common Stock" means the Common Stock of the Company, par value $.01
per share, either currently existing or authorized hereafter.

           "Company" means Adolor Corporation, a Delaware corporation.

           "Director" means a member of the Board who is not an employee of the
Company or its Subsidiaries.

           "Exchange Act" means the Securities Exchange Act of 1934, as amended.

           "Exercise Price" means the exercise price per Share of an Option.

           "Fair Market Value" per Share as of a particular date means (i) if
Shares are then listed on a national stock exchange, the closing sales price per
Share on the exchange for the last preceding date on which there was a sale of
Shares on such exchange, as determined by the Administrator, (ii) if Shares are
not then listed on a national stock exchange but are then traded on an over-the-
counter market, the average of the closing bid and asked prices for the Shares
in such over-the-counter market for the last preceding date on which there was a
sale of such Shares in such market, as determined by the Administrator, or (iii)
if Shares are not then listed on a national stock exchange or traded on an over-
the-counter market, or if the Administrator determines that the that the value
as determined pursuant to Section (i) or (ii) above does not

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reflect fair market value, the Administrator shall determine fair market value
after taking into account such factors that it deems appropriate.

           "Grant Letter" means a written agreement in a form approved by the
Administrator to be entered into by the Company and the Optionee as provided in
Section 3.

           "Incentive Stock Option" means "incentive stock option" within the
meaning of Section 422(b) of the Code.

           "Non-Qualified Option" means an Option which is not intended to be an
"incentive stock option" within the meaning of Section 422(b) of the Code.

           "Option" means the right to purchase, at the price and for the term
fixed by the Administrator in accordance with the Plan, and subject to such
other limitations and restrictions in the Plan and the applicable Grant Letter,
a number of Shares determined by the Administrator.

           "Optionee" means an employee or Director of or consultant to, the
Company to whom an Option is granted, or the Successors of the Optionee, as the
context so requires.

           "Person" means any individual, partnership, corporation, company,
limited liability company, association, trust, joint venture, unincorporated
organization, entity or division, or any government, governmental department or
agency or political subdivision thereof.

           "Plan" means this Adolor Corporation Amended and Restated 1994 Equity
Compensation Plan as amended from time to time.

           "Public Offering" means a successfully completed firm-commitment
underwritten public offering (other than a Unit Offering, as hereinafter
defined) pursuant to an effective registration statement under the Securities
Act in respect to the offer and sale of shares of Common Stock for the account
of the Company resulting in aggregate net proceeds to the Company and any
stockholder selling shares of Common Stock in such offering of not less than $25
million.

           "Securities Act" means the Securities Act of 1933, as amended.

           "Shares" means shares of Common Stock of the Company.

           "Subsidiary" means any corporation (other than the Company) that is a
"subsidiary corporation" with respect to the Company under Section 424(f) of the
Code. In the event the Company becomes a subsidiary of another company, the
provisions hereof applicable to subsidiaries shall, unless otherwise determined
by the Administrator, also be applicable to any company that is a "parent
corporation" with respect to the Company under Section 424(e) of the Code.

           "Successor of the Optionee" means: (i) the legal representative of
the estate of a deceased Optionee or the person, (ii) persons who shall acquire
the right to exercise an Option by bequest or inheritance or other transfer or
by reason of the death of the Optionee, (iii) if permitted by the Administrator
in its sole discretion, any person who shall acquire the right to

                                      -3-
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exercise an Option pursuant to any other transfer of the Option either pursuant
to Section 12 hereof or pursuant to Court Order or (iv) persons who shall
acquire the right to exercise an Option on behalf of the Optionee as the result
of a determination by a court or other governmental agency of the incapacity of
the Optionee.

           "Termination of Service" means an Optionee's termination of
employment or other service, as applicable, with the Company and its
Subsidiaries. Cessation of service as an officer, employee, director or
consultant shall not be treated as a Termination of Service if the Optionee
continues without interruption to serve thereafter in a material manner in
another one (or more) of such other capacities, as determined by the
Administrator in its sole discretion.

           "Unit Offering" means an underwritten public offering of a
combination of debt securities and Common Stock (or warrants or exchange rights
to purchase Common Stock) of the Company in which not more than 15% of the gross
proceeds received for the sale of such securities is attributed to Common Stock.

2.   EFFECTIVE DATE AND TERMINATION OF PLAN.
     --------------------------------------

           The effective date of the Plan is February___, 2000. The Plan shall
terminate on, and no Option shall be granted hereunder on or after, the 10-year
anniversary of the earlier of the approval of the Plan by (i) the Board or (ii)
the stockholders of the Company; provided, however, that the Board may at any
time prior to that date terminate the Plan.

3.   ADMINISTRATION OF PLAN.
     ----------------------

           (a) The Plan shall be administered by the Administrator, which shall
be either the Board, or a Committee appointed by the Board, who shall, on behalf
of the Board, have full responsibility and authority to administer the Plan. The
Administrator shall, at such times as the Common Stock, or shares of such other
stock that may be the subject of Options hereunder, are registered pursuant to
Section 12 of the Exchange Act, consist of at least two individuals each of whom
shall be a "nonemployee director" as defined in Rule 16b-3 as promulgated by the
Securities and Exchange Commission under the Exchange Act and shall, at such
times as the Company is subject to Section 162(m) of the Code (to the extent
relief from the limitation of Section 162(m) of the Code is sought), qualify as
"outside directors" for purposes of Section 162(m) of the Code and related
Treasury regulations. The acts of a majority of the members present at any
meeting of the Administrator at which a quorum is present, or acts approved in
writing by a majority of the entire Administrator, shall be the acts of the
Administrator for purposes of the Plan. If and to the extent applicable, no
member of the Administrator may act as to matters under the Plan specifically
relating to such member.

           (b) Subject to the provisions of the Plan, the Administrator shall in
its discretion as reflected by the terms of the Grant Letters (i) authorize the
granting of Incentive Stock Options and Non-Qualified Options to employees,
Directors and consultants of the Company and its Subsidiaries; and (ii)
determine the eligibility of an employee, Director or consultant to receive an
Option subject to Section 4 hereof, (iii) specify whether such Option is an
Incentive Stock Option or Non-Qualified Option and (iv) determine the number of
Shares to be covered under any Grant Letter, considering the position an
responsibilities of the employee,

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Director or consultant, the nature and value to the Company of the employee's,
Director's or consultant's present and potential contribution to the success of
the Company whether directly or through a Subsidiaries and such other factors as
the Administrator may deem relevant.

           (c) The Grant Letter shall contain such other terms, provisions and
conditions not inconsistent herewith as determined by the Administrator. The
Optionee shall take whatever additional actions and execute whatever additional
documents the Administrator may in its reasonable judgment deem necessary or
advisable in order to carry out or effect one or more of the obligations or
restrictions imposed on the Optionee pursuant to the express provisions of the
Plan and the Grant Letter.

4.   ELIGIBILITY.
     -----------

           Any employee, Director or consultant of the Company or a Subsidiary
who is designated by the Administrator as eligible to participate in the Plan
shall be eligible to receive an Option under the Plan.

5.   SHARES AND UNITS SUBJECT TO THE PLAN.
     ------------------------------------

           (a) Subject to adjustments as provided in Section 16, the total
number of Shares subject to Options granted under the Plan, in the aggregate,
may not exceed 19,750,000 Shares distributed under the Plan may be treasury
Shares or authorized but unissued Shares. Any Shares that have been reserved for
distribution in payment for Options but are later forfeited or for any other
reason are not payable under the Plan may again be made the subject of Options
under the Plan.

           (b) The certificates for Shares issued hereunder may include any
legend which the Administrator deems appropriate to reflect any restrictions on
transfer hereunder or under the Grant Letter , or as the Administrator may
otherwise deem appropriate.

           (c) In no event may any Optionee receive Options for more than
1,000,000 shares in any calendar year. The aggregate fair market value of the
shares on the date of the grant with respect to which Incentive Stock Options
are exercisable for the first time by an Optionee during any calendar year under
the Plan and under any other stock option plan of the Company shall not exceed
$100,000.

6.   GRANT OF OPTION.
     ---------------

           Subject to the other terms of the Plan, the Administrator shall, in
its discretion as reflected by the terms of the applicable Grant Letter: (i)
determine and designate from time to time those eligible employees, Directors
and consultants of the Company and its Subsidiaries to whom Options are to be
granted and the number of Shares to be optioned to each employee and consultant
(provided that Incentive Stock Options may only be granted to employees); (ii)
determine the time or times when and the manner and condition in which each
Option shall be exercisable and the duration of the exercise period; and (iii)
determine or impose other conditions to the grant or exercise of Options under
the Plan as it may deem appropriate.

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7.   OPTION PRICE.
     ------------

           Unless otherwise determined by the Administrator as reflected in the
Grant Letter, the Exercise Price shall not be less than 100% (or 110% for
Incentive Stock Options with respect to individuals described in Section
422(b)(6) of the Code (relating to 10% owners)) of the Fair Market Value of a
Share on the day the Option is granted.

8.   TERM OF OPTIONS; VESTING AND EXERCISABILITY.
     -------------------------------------------

           (a) The Administrator shall establish the term of each Option, as set
forth in the Grant Letter; provided that in no event shall any Option have a
term greater than 10 years from the date of grant (except that, in the case of
an individual described in Section 422(b)(6) of the Code (relating to 10%
owners), the term of any Incentive Stock Option shall be no more than five years
from the date of grant). Unless earlier expired, forfeited or otherwise
terminated, each Option shall expire in its entirety upon the day after the last
day of its term. The Option shall also expire, be forfeited and terminate at
such times and in such circumstances as otherwise provided hereunder or under
the Grant Letter.

           (b) Each Option, to the extent that the Optionee has not had a
Termination of Service and the Option has not otherwise lapsed, expired,
terminated or been forfeited, shall vest according to the vesting schedule which
shall be determined in the sole and absolute discretion of the Administrator as
set forth in the Grant Letter

           (c) The Grant Letter may, but need not, include a provision whereby
the Optionee may elect at any time while still an employee of or a consultant to
the Company to exercise a Non-Qualified Option as to any part or all of the
Shares subject to the Option prior to the full vesting of the Option. Any Shares
so purchased (i) shall vest in accordance with the vesting schedule otherwise
applicable to the Option, (ii) shall be subject to a repurchase right in favor
of the Company as provided in Section 9 below, and (iii) shall be subject to any
other restriction the Company determines to be appropriate.

           (d) Notwithstanding the foregoing provisions of this Section 8,
Options exercisable pursuant to the schedule set forth by the Administrator at
the time of grant may be fully or more rapidly exercisable or vested, and Shares
subject to such schedule may be fully or more rapidly vested, at any time in the
discretion of the Administrator. Upon and after the death of an Optionee, such
Optionee's Options, if and to the extent otherwise exercisable hereunder or
under the applicable Grant Letter after the Optionee's death, may be exercised
by the Successors of the Optionee.

9.   EXERCISABILITY UPON AND AFTER TERMINATION OF OPTIONEE.
     -----------------------------------------------------

     9.1.  Termination on Retirement, Disability, Death or without Cause.
           -------------------------------------------------------------

           Unless otherwise provided in the applicable Grant Letter, if an
Optionee has a Termination of Service other than a Termination of Service due to
death or for cause, the unexercised and vested portion of such Optionee's Option
will remain exercisable by the Optionee, the Optionee's estate, the persons who
acquired the right to exercise the Option by bequest or inheritance, as
applicable, for a period of 90 days following such Termination of

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Service, but in no event later than the last day of the term of the Option. Such
portion of the Option shall terminate to the extent not exercised within such
period. Unless otherwise provided in the Grant Letter, upon such a Termination
of Service, any unvested portion of an Option will terminate and will be
forfeited, and any Shares purchased pursuant to Section 8(c) above which are
unvested at the time of such Termination of Service shall be subject to a
repurchase right in favor of the Company for a price equal to the lesser of (x)
the Exercise Price of the Shares or (y) the Fair Market Value of such Shares on
the date of repurchase, which right must be exercised by the Company within 90
days of such Termination of Service; provided that if the Company does not
exercise such right within such 90-day period, the Optionee shall become fully
and immediately vested in such Shares.

     9.2.  Termination for Cause.
           ---------------------

           If an Optionee has a Termination of Service on account of a
termination for Cause, any Option held by the Optionee will immediately expire
on the date of such Termination of Service, and the Company has the right (but
not the obligation to) repurchase any unvested or vested Shares held by the
Optionee for a price equal to the lesser of (x) the Option Price of the Shares
or (y) the Fair Market Value of the Shares on the date of repurchase; provided
such right must be exercised within six months of the applicable Termination of
Service, and provided, further, that if the Company does not exercise such right
within such six-month period, the Optionee shall become fully and immediately
vested in such Shares.

     9.3.  Termination due to Optionee's Death.
           -----------------------------------

           Unless otherwise provided in the applicable Grant Letter, if an
Optionee has a Termination of Service due to the Optionee's death or if the
Optionee dies within the 90-day period following any Termination of Service
other than a Termination for Cause, the unexercised and vested portion of such
Optionee's Option will remain exercisable by the Optionee's estate or the
persons who acquired the right to exercise the Option by bequest or inheritance,
as applicable, until one year from the date of death but in no event later than
the last day of the term of the Option. Such portion of the Option shall
terminate to the extent not exercised within such period. Unless otherwise
provided in the Grant Letter , upon such Termination of Service, any unvested
portion of an Option will terminate and will be forfeited, and any Shares
purchased pursuant to Section 8(c) above which are unvested at the time of such
Termination of Service shall be subject to a repurchase right in favor of the
Company for a price equal to the lesser of (x) the Exercise Price of the Shares
or (y) the Fair Market Value of such Shares on the date of repurchase, which
right must be exercised by the Company within 90 days of such Termination of
Service; provided that if the Company does not exercise such right within such
90-day period, the Optionee shall become fully and immediately vested in such
Shares.

     9.4.  In General.
           ----------

           Except as may otherwise be expressly set forth in Section 8 or this
Section 9 or as may otherwise be expressly provided under the Grant Letter, no
provision of this Section 9 is intended to or shall permit the exercise of the
Option to the extent the Option was not exercisable upon the Termination of
Service.

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10.  EXERCISE OF OPTIONS; PAYMENT.
     ----------------------------

     10.1. Notice of Exercise.
           ------------------

           (a) Subject to vesting and other restrictions provided for hereunder
or otherwise imposed in accordance herewith, an Option may be exercised, and
payment in full of the aggregate Exercise Price made, by an Optionee only by
written notice (in the form prescribed by the Administrator) to the Company
specifying the number of Shares to be purchased.

           (b) Without limiting the scope of the Administrator's discretion
hereunder, the Administrator may impose such other restrictions on the exercise
of Incentive Stock Options (whether or not in the nature of the foregoing
restrictions) as it may deem necessary or appropriate.

           (c) If Shares acquired upon the exercise of an Incentive Stock Option
are disposed of in a disqualifying disposition within the meaning of Section 422
of the Code by an Optionee prior to the expiration of either two years from the
date of grant of such Option or one year from the transfer of Shares to the
Optionee pursuant to the exercise of such Option, or in any other disqualifying
disposition within the meaning of Section 422 of the Code, such Optionee shall
notify the Company in writing as soon as practicable thereafter of the date and
terms of such disposition and, if the Company (or any affiliate thereof)
thereupon has a tax withholding obligation, shall pay to the company (or such
affiliate) an amount equal to any withholding tax the Company (or affiliate) is
required to pay as a result of the disqualifying disposition.

     10.2. Form of Payment.
           ---------------

           (a) The aggregate Exercise Price shall be paid in full upon the
exercise of the Option. Payment must be made by one of the following methods:

               (i)   cash or a certified or bank cashier's check;

               (ii)  the proceeds of a Company loan program or third party sale
program or a note acceptable to the Administrator given as consideration under
such a program, in each case if permitted by the Administrator in its
discretion, if such a program has been established and the Optionee is eligible
to participate therein;

               (iii) if approved by the Administrator in its discretion Shares
of previously owned Common Stock having an aggregate Fair Market Value on the
date of exercise equal to the aggregate Option Price;

               (iv)  if approved by the Administrator of its discretion, by
delivery of an assignment satisfactory in form and substance to the Company of a
sufficient amount of the proceeds from the sale of Shares to be acquired
pursuant to such exercise and an instruction to the broker or selling agent to
pay that amount to the Company; or

               (v)   by a combination of such methods of payment or any other
method acceptable to the Administrator in its discretion.

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<PAGE>

           (b) Except in the case of Options exercised by certified or bank
cashier's check, the Administrator may impose limitations and prohibitions on
the exercise of Options as it deems appropriate, including, without limitation,
any limitation or prohibition designed to avoid accounting consequences which
may result from the use of Common Stock as payment upon exercise of an Option.
Any fractional Shares resulting from an Optionee's election that is accepted by
the Company shall be paid in cash.

11.  EXERCISE BY SUCCESSORS.
     ----------------------

           An Option may be exercised, and payment in full of the aggregate
Exercise Price made, by the Successors of the Optionee only by written notice
(in the form prescribed by the Administrator) to the Company specifying the
number of Shares to be purchased. Such notice shall state that the aggregate
Option Price will be paid in full, or that the Option will be exercised as
otherwise provided hereunder, in the discretion of the Company or the
Administrator, if and as applicable.

12.  NONTRANSFERABILITY OF OPTION.
     ----------------------------

           Each Option granted under the Plan shall by its terms be
nontransferable by the Optionee except by will or the laws of descent and
distribution of the state wherein the Optionee is domiciled at the time of his
death; provided, however, that the Administrator may (but need not) permit other
transfers of Non-Qualified Options where the Administrator concludes that such
transferability does not result in accelerated U.S. federal income taxation and
is otherwise appropriate and desirable.

13.  TAX WITHHOLDING.
     ---------------

     13.1. In General.
           ----------

           The Company shall be entitled to withhold from any payments or deemed
payments any amount of tax withholding determined by the Administrator to be
required by law. Without limiting the generality of the foregoing, the
Administrator may, in its discretion, require an Optionee to pay to the Company
at such time as the Administrator determines the amount that the Administrator
deems necessary to satisfy the Company's obligation to withhold federal, state
or local income or other taxes incurred by reason of the exercise of any Option.

     13.2. Share Withholding.
           -----------------

           Upon the exercise of an Option, the Optionee may, if approved by the
Administrator in its discretion, make a written election to have Shares then
issued withheld by the Company from the Shares otherwise to be received, or to
deliver previously owned Shares, in order to satisfy the liability for such
withholding taxes. In the event that the Optionee makes, and the Administrator
permits, such an election, the number of Shares so withheld or delivered shall
have an aggregate Fair Market Value on the date of exercise sufficient to
satisfy the applicable withholding taxes.

     13.3. Withholding Required.
           --------------------

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<PAGE>

           Notwithstanding anything contained in the Plan to the contrary, the
Optionee's satisfaction of any tax-withholding requirements imposed by the
Administrator shall be a condition precedent to the Company's obligation as may
otherwise be provided hereunder to provide Shares to the Optionee and to the
release of any restrictions as may otherwise be provided hereunder, as
applicable; and the applicable Option shall be forfeited upon the failure of the
Optionee to satisfy such requirements with respect to the exercise of the
Option.

14.  REGULATIONS AND APPROVALS
     -------------------------

           (a) The obligation of the Company to sell Shares with respect to an
Option granted under the Plan shall be subject to all applicable laws, rules and
regulations, including all applicable federal and state securities laws, and the
obtaining of all such approvals by governmental agencies as may be deemed
necessary or appropriate by the Administrator.

           (b) The Administrator may make such changes to the Plan as may be
necessary or appropriate to comply with the rules and regulations of any
government authority or to obtain tax benefits applicable to an Option.

           (c) Each grant of Options is subject to the requirement that, if at
any time the Administrator determines, in its discretion, that the listing,
registration or qualification of Shares issuable pursuant to the Plan is
required by any securities exchange or under any state or federal law, or the
consent or approval of any governmental regulatory body is necessary or
desirable as a condition of, or in connection with, the issuance of Options no
payment shall be made in whole or in part, unless listing, registration,
qualification, consent or approval has been effected or obtained free of any
conditions in a manner acceptable to the Administrator.

           (d) In the event that the disposition of stock acquired pursuant to
the Plan is not covered by a then current registration statement under the
Securities Act, and is not otherwise exempt from such registration, such Shares
shall be restricted against transfer to the extent required under the Securities
Act, and the Administrator may require any individual receiving Shares pursuant
to the Plan, as a condition precedent to receipt of such Shares, to represent to
the Company in writing that such Shares will be disposed of only if registered
for sale under the Securities Act or if there is an available exemption for such
disposition.

15.  INTERPRETATION AND AMENDMENTS, OTHER RULES.
     ------------------------------------------

     15.1. The Administrator may make such rules and regulations and establish
such procedures for the administration of the Plan as it deems appropriate.
Without limiting the generality of the foregoing, the Administrator may (i)
determine the extent, if any, to which Options shall be forfeited (whether or
not such forfeiture is expressly contemplated hereunder); (ii) interpret the
Plan and the Grant Letters hereunder, with such interpretations to be conclusive
and binding on all persons and otherwise accorded the maximum deference
permitted by law, provided that the Administrator's interpretation shall not be
entitled to deference on and after a Change of Control except to the extent that
such interpretations are made exclusively by members of the Administrator who
are individuals who served as Administrator members before the Change of
Control; and (iii) take any other actions and make any other determinations or
decisions that it deems necessary or appropriate in connection with the Plan or
the administration

                                      -10-
<PAGE>

or interpretation thereof. Unless otherwise expressly provided hereunder, the
Administrator, with respect to any grant, may exercise its discretion hereunder
at the time of the grant or thereafter. In the event of any dispute or
disagreement as to the interpretation of the Plan or of any rule, regulation or
procedure, or as to any question, right or obligation arising from or related to
the Plan, the decision of the Administrator, except as provided in clause (ii)
of the foregoing sentence, shall be final and binding upon all persons. The
Board may amend the Plan as it shall deem advisable, except that no amendment
may adversely affect an Optionee with respect to an Option previously granted
unless such amendments are required in order to comply with applicable laws;
provided that the Board may not make any amendment in the Plan that would, if
such amendment were not approved by the holders of the Common Stock, cause the
Plan to fail to comply with any requirement of applicable law or regulation,
unless and until the approval of the holders of such Common Stock is obtained.

     15.2. Right of Repurchase. Without limiting the Company's right of
           -------------------
repurchase upon (i) a Termination of Service, (ii) upon a Change in Control, or
(iii) prior to an Approved Sale (or upon the consummation of an Approved Sale)
or a Public Offering, the Company reserves the right (but not the obligation) to
repurchase any vested Shares for a price equal to the Fair Market Value of the
Shares on the date of such repurchase.

16.  CHANGES IN CAPITAL STRUCTURE; CHANGE OF CONTROL.
     -----------------------------------------------

     16.1. Changes in Capital Structure.
           ----------------------------

           (a) If (i) the Company shall at any time be involved in a merger,
consolidation, dissolution, liquidation, reorganization, exchange of shares,
sale of all or substantially all of the assets or stock of the Company or a
transaction similar thereto, (ii) any stock dividend, stock split, reverse stock
split, stock combination, reclassification, recapitalization or other similar
change in the capital structure of the Company or any distribution to holders of
Common Stock other than cash dividends, shall occur or (iii) any other event
shall occur which in the judgment of the Administrator necessitates action by
way of adjusting the terms of the outstanding Options, then (x) the maximum
aggregate number of Shares which may be made subject to Options under the Plan
shall be appropriately adjusted by the Administrator; and (y) the Administrator
shall take any such action as in its judgment shall be necessary to preserve the
Optionees' rights in their respective Options substantially proportionate to the
rights existing in such Options prior to such event, including, without
limitation, adjustments in (A) the number of Options granted, (B) the number and
kind of shares or other property to be distributed in respect of Options, and
(C) the Exercise Price.

     16.2. Change of Control or Approved Sale.
           ----------------------------------

           (a) Upon a Change of Control or an Approved Sale unless otherwise
provided in an Optionee's Grant Letter, the vesting and exercisability of all
Options that are outstanding and unexercised as of such Change of Control, to
the extent unvested, and any unvested shares held by the Optionee shall be
accelerated such that all outstanding Options are fully vested and exercisable
and all Shares held by the Optionee are fully vested, and, if the Company does
not survive such Change of Control or an Approved Sale, the Company shall, if
the Company does not cash-out all outstanding options, require the successor
corporation to the Company to assume

                                      -11-
<PAGE>

all outstanding Options and to substitute such Options with awards involving the
common stock of such successor corporation on terms and conditions necessary to
preserve the rights of Optionees with respect to such Options. Upon a Change of
Control or an Approved Sale, the Administrator, in its sole discretion, may
require the Company to cancel all outstanding vested Options (including those
Options vested upon a Change of Control or an Approved Sale) in exchange for a
cash payment in an amount equal to the excess, if any, of the Fair Market Value
of the Common Stock underlying the unexercised portion of the Option as of the
date of the Change of Control or Approved Sale over the Option Price of such
portion. Notwithstanding anything in the Plan to the contrary, in the event of
an Approved Sale or a Change of Control, the Administrator shall not have the
right to take any actions described in the Plan (including without limitation
actions described in this Section 16.2) that would make the Approved Sale or
Change of Control ineligible for pooling of interests accounting treatment or
that would make the Approved Sale or Change of Control ineligible for desired
tax treatment if, in the absence of such right, the transaction would qualify
for such treatment and the Company intends to use such treatment with respect to
the transaction, in which case the Administrator and the Company shall be
required to take the action described in the first sentence of this Section
16.2.

     16.3. Administrator Authority. The judgment of the Administrator with
           -----------------------
respect to any matter referred to in this Section 16 shall be conclusive and
binding upon each Optionee without the need for any amendment to the Plan.

17.  MISCELLANEOUS.
     -------------

     17.1. No Rights to Employment or Other Service.
           ----------------------------------------

           Nothing in the Plan or in any grant made pursuant to the Plan shall
confer on any individual any right to continue in the employ or other service of
the Company or its Subsidiaries or interfere in any way with the right of the
Company or its Subsidiaries and its stockholders to terminate the individual's
employment or other service at any time.

     17.2. No Fiduciary Relationship.
           -------------------------

           Nothing contained in the Plan, and no action taken pursuant to the
provisions of the Plan, shall create or shall be construed to create a trust of
any kind, or a fiduciary relationship between the Company or its Subsidiaries,
or their officers or the Administrator, on the one hand, and the Optionee, the
Company, its Subsidiaries or any other person or entity, on the other.

     17.3. Notices.
           -------

           All notices under the Plan shall be in writing, and if to the
Company, shall be delivered to the Board or mailed to its principal office,
addressed to the attention of the Board; and if to the Optionee, shall be
delivered personally, sent by facsimile transmission or mailed to the Optionee
at the address appearing in the records of the Company. Such addresses may be
changed at any time by written notice to the other party given in accordance
with this Section 17.3.

                                      -12-
<PAGE>

     17.4. Exculpation and Indemnification.
           -------------------------------

           The Company shall indemnify and hold harmless the members of the
Board and the members of the Administrator, from and against any and all
liabilities, costs and expenses incurred by such persons as a result of any act
or omission to act in connection with the performance of such person's duties,
responsibilities and obligations under the Plan, to the maximum extent permitted
by law, other than such liabilities, costs and expenses as may result from the
gross negligence, bad faith, willful misconduct or criminal acts of such
persons.

     17.5. Captions.
           --------

           The use of captions in this Plan is for convenience. The captions are
not intended to provide substantive rights.

     17.6. Governing Law.
           -------------

           THE PLAN SHALL BE GOVERNED BY THE LAWS OF THE STATE OF DELAWARE
WITHOUT REFERENCE TO PRINCIPLES OF CONFLICTS OF LAWS.

           IN WITNESS WHEREOF, on behalf of Adolor Corporation and pursuant to
the direction of the Board, the undersigned hereby adopts the Plan as set forth
herein.

                                             Adolor Corporation
                                             ------------------

                                             By: _______________________________

                                             Title: ____________________________

                                      -13-<PAGE>

                                                                    Exhibit 10.6

                              SUBLEASE AGREEMENT

     THIS SUBLEASE AGREEMENT ("Sublease") is made this 11th day of September,
2000, by and between Environ Products, Inc., a Pennsylvania corporation with a
principal place of business at 107 North Tech Drive, Clayton, NC 27520
("Sublessor"), and Adolor Corporation, a Delaware corporation with a principal
place of business at 371 Phoenixville Pike, Malvern, PA 19355 ("Sublessee").

     WHEREAS, Sublessor is the lessee of space in a building located at 620
Pennsylvania Drive, Exton, PA 19341 (the "Premises"), pursuant to that certain
lease agreement (the "Prime Lease") dated August 29, 1996 by and between
Sublessor, as tenant ("Tenant"), and M3 Partners, L.P., as landlord (the
"Landlord") (a copy of the Prime Lease is attached hereto and incorporated
herein as Exhibit "A");

     WHEREAS, the legal description of the Premises is contained in Exhibit A to
the Prime Lease which is incorporated into and made a part of this Sublease; and

     WHEREAS, Sublessor desires to lease the Premises to Sublessee and Sublessee
desires to lease the Premises from Sublessor all pursuant to the terms and
conditions contained herein.

     NOW THEREFORE, intending to be legally bound hereby, in consideration of
the mutual covenants contained herein and the background set forth above, the
parties hereto hereby agree as follows:

1.   Premises. Sublessor hereby leases to Sublessee, and Sublessee hereby leases
from Sublessor the Premises, including the building located thereon (the
"Building") and the furniture, murals and wall hangings located in the Building
as set forth on Exhibit "B" hereto. Sublessee has had the opportunity to inspect
the Premises and the aforesaid furniture, murals and wall hangings and
acknowledges all of same to be in average condition for a three year old
building.

2.   Term. The term of this Sublease will be for a period of two (2) years (each
a "Lease Year"), commencing on October 15, 2000 (the "Commencement Date") and
ending on October 15, 2002 (the "Term"). At the end of said term, including any
renewals or extensions thereof, the Premises, including all of the furniture
therein as set forth on Exhibit "B", shall be returned to Sublessor in the same
condition as on the date hereof, reasonable wear and tear excepted.

3.   Rent.

     A.    For and during the first year of this Sublease, Sublessee will pay to
Sublessor without right to set-off or reduction (other than as specified in
Section 11) as rent for the Premises a total minimum annual rental ("Base Rent")
of three hundred sixty-five thousand ($365,000.00) dollars, plus a common area
maintenance ("CAM") charge (covering all expenses incurred by Sublessor pursuant
to the performance of its maintenance and operational obligations under this
Sublease as specified in Section 5 ("Sublessor's Services"), adjusted pursuant
                         ---------
to the
<PAGE>

provisions of Section 4, but in no event less than one hundred thousand
              ---------
($100,000.00) dollars annually. For and during the second year of this Sublease,
Sublessee will pay to Sublessor a Base Rent for the Premises of three hundred
and eighty-five hundred thousand ($385,000.00) dollars, together with CAM
adjusted according to Sublessor's costs for same, but in no event less than one
hundred thousand ($100,000.00) dollars. Sublessee shall pay such Base Rent and
CAM charges together in monthly installments in advance during the Term of this
Sublease or any renewal hereof in sums of not less than thirty-eight thousand
seven hundred and fifty ($38,750.00) dollars during the first year (subject to
an upward adjustment for the CAM charges), and not less than forty thousand four
hundred and seventeen ($40,417.67) dollars and sixty-seven cents during the
second year (subject to an upward adjustment for the CAM charges). The first
payment with respect to this Sublease shall be made at the time of the execution
of this Sublease and shall consist of rent payable for the stub period extending
from October 15, 2000 through October 31, 2000), together with one (1) month's
rent as security deposit to be paid. Thereafter installments of rent shall be
paid on the first day of each month. All rent or other payments hereunder shall
be made during business hours at 600 Greenridge Road, Glenmoore, PA 19343, or at
such other places as Sublessor may from time to time after the date hereof,
designate. CAM charges, together with any other amount in addition to Base Rent,
payable by Sublessee under this Sublease shall sometimes be referred to herein
as "Additional Rent").

     B.   Any rental payment made more than fifteen (15) days after it is due
shall be paid with a late charge of one percent (1%) thereof. Sublessee agrees
that the foregoing late charge represents a reasonable estimate of the
additional administrative accounting and other expenses which Sublessor will
incur as a result of such non-payment, which cost and expenses are extremely
difficult to otherwise fix or quantify.

4.   CAM Charges.

     A.   Sublessor shall be responsible for providing all Sublessor's Services
(but excluding janitorial and building security services) and paying all related
expenses (other than the cost of separately metered utilities and liability
insurance coverage) with respect to the Premises. Such expenses ("Operating
Expenses") will be reimbursed by Sublessee solely through the payment of the CAM
charges. Sublessee shall obtain at its sole cost, its own liability insurance
pursuant to Section 12.B. Sublessee shall also provide, at its sole cost, all
            ------------
janitorial services and security services with respect to the Premises.

     B.   In order to be reimbursable, any CAM charges exceeding $100,000 per
year must be reasonable, actual and necessary out-of-pocket expenses, obtained
at competitive prices, that are directly attributable to the operation,
maintenance, management, and repair of the Premises. Sublessor shall use
reasonable efforts to operate the Building efficiently and minimize Operating
Expenses, while maintaining a first class office building.

     C.   Sublessor shall pay the estimated CAM charge on a monthly basis
pursuant to Section 3.A. above. If Sublessor subsequently anticipates that the
            -----------
CAM charges will exceed $100,000 in any Lease Year, it shall so notify Sublessee
and provide an explanation for such

                                      -2-
<PAGE>

divergence. In such event, provided Sublessee reasonably consents to such change
in the CAM charge, the CAM charge will be increased and such revised amount
shall thereafter be paid by Sublessee on a monthly basis during the remainder of
the applicable Lease Year.

     D.    If the CAM charges exceeds $100,000 annually, then at the end of the
applicable Lease Year, Sublessor shall compute the actual Operating Expenses
incurred with respect to the Premises. Within 30 days after the end of such
Lease Year, or such earlier time as reasonably practical, Sublessor shall give
Sublessee an itemized statement (the "Statement") showing in reasonable detail
the following: (1) actual Operating Expenses for the Lease Year broken down by
component expenses, (2) real estate taxes for the Lease Year, (3) the amount, if
any, paid by Sublessee during the Lease Year on account of CAM charges, and (4)
the Underpayment (as defined herein).

     E.    If the Statement shows that the actual amount Sublessee owes for the
Lease Year is more than the CAM charges paid by Sublessee for such Lease Year,
Sublessee shall pay the difference (the "Underpayment") as Additional Rent. The
Underpayment shall be paid within thirty (30) days after the Statement is
delivered to Sublessee.

     F.    If the CAM charges exceed $100,000 annually, Sublessee shall have the
right to audit Sublessor's books and records concerning the Statement at
Sublessor's offices during normal business hours. The books and records shall be
kept in accordance with generally accepted accounting principles consistently
applied. If Sublessee disputes the accuracy of Sublessor's Statement, Sublessee
shall still pay the amount shown owing. Sublessee may recover that part of the
Additional Rent paid (plus interest at 1% per annum over the prime rate),
because of errors in the Statement, books, or records of Sublessor.

5.   Sublessor's Services. Sublessor agrees to maintain and keep in good repair
the Premises, the Building and its systems and any and all equipment, fixtures
and appurtenances furnished by Sublessor, except for uninsured damage (other
than reasonable wear and tear) arising from any act or omission of Sublessee,
its agents or employees, which shall be repaired by Sublessee at Sublessee's
expense. Repairs which affect business operations in the Premises shall be
scheduled after hours to the extent feasible, and in all events, shall use
commercially reasonable efforts to minimize interference with Sublessee's
business operations in performing such services. Such services to be provided by
Sublessor (the "Sublessor Services") shall specifically include the following:

     A.    Heating, ventilation and air conditioning for the comfortable use and
occupation of the Premises on a 24 hour, 7 days a week, year-round basis, to
maintain the temperatures within the parameters customary for first class
suburban office building. Sublessor will maintain, repair and replace the
heating, ventilation, and air conditioning system as necessary and will use all
reasonable care to keep it in proper and efficient operating condition.
Sublessee shall be responsible for all regular utility consumption charges with
respect to such service.

     B.    Maintenance of all electrical supply systems, wiring, transformers
and the like pursuant to its obligations as Tenant under the Prime Lease; but
Sublessee shall be solely

                                      -3-
<PAGE>

responsible for, and shall make its own arrangements respecting, the supply of
electrical, telephone and other utility and other services from utility
providers.

     C.    Casualty insurance with respect to the Building as required under
Section 12.A.
------------

     D.    Adequate hot and cold water for all of Sublessee's ordinary needs.

     E.    Adequate freight and passenger elevator service on a 24 hour , 7 days
a week, year-round basis.

     F.    Parking, snow removal, lawn care and other similar services with
respect to the Premises in accordance with the customary standards for first
class suburban office buildings.

6.   Use of Premises. Sublessee may use the Premises for office space and for
any other uses normally incident to such office use, and for no other purposes.

7.   Assumption. During the term of this Sublease, Sublessee will be bound to
and comply with only the provisions of the Prime Lease specified in this Section
5 of this Sublease, and shall have no obligations to Sublessor or Landlord with
respect to any other obligations of Tenant under the Prime Lease. Sublessee
specifically agrees to perform and/or be subject to the obligations of Tenant
under the Prime Lease contained in Paragraphs 7, (the PIDA provisions only), 8,
10, 11, 12(b), 15 (subject to any limitations specified in this Sublease with
respect to such obligations), and, to the extent of the Premises, to assume
toward Sublessor and perform all of such incorporated obligations and
responsibilities, and to indemnify and hold harmless Sublessor from any claim or
liability specifically assumed hereby. Any capitalized terms used but not
defined in this Sublease shall have the meaning specified for such term under
the Prime Lease.

     Attached to this Lease is Landlord's consent to this Sublease, the
execution of which shall be an absolute condition to the effectiveness of this
Lease. If the Prime Lease is canceled or otherwise terminated prior to the
expiration date of this Sublease, or any extensions and renewals hereof approved
by Landlord, the Landlord will not terminate this Sublease, provided Sublessor
is not in default hereunder.

8.   Limitation of Liability. Notwithstanding any provision of the Prime Lease
to the contrary, neither Landlord nor Sublessor will be liable to Sublessee, or
any of Sublessee's agents, employees, servants, or invitees, for any injuries to
persons or damage to the Sublessee's property due to the condition or design or
any defect of the Premises which may presently exist or subsequently occur,
other than if such design or defect is directly attributable to Sublessor's
willful failure to perform its obligations under this Sublease. Sublessee
expressly assumes all risks and damage to persons and property, either
proximately or remotely, with respect to Sublessee and Sublessee's agents,
employees, servants, and invitees, by reason of the present or future condition
of the Premises, other than conditions directly attributable to Sublessor's
willful failure to perform its obligations under this Sublease. Sublessee agrees
to defend, indemnify and hold harmless Sublessor and Landlord from and against
all suits, claims, and actions of every

                                      -4-
<PAGE>

kind by reason of any breach, violation, or nonperformance of any term or
conditions of this Sublease on the part of Sublessee.

     Additionally, Sublessee agrees to defend, indemnify and hold Sublessor and
Landlord harmless from and against all claims, actions, damages, liabilities,
and expenses asserted against Sublessor and/or Landlord on account of injuries
to persons or damage to property other than such expenses directly attributable
to Sublessor's or Landlord's willful failure to perform its obligations under
this Sublease. This holds true when and to the extent that any such damage or
injury may be caused, either proximate or remote, wholly or in part, by any act
of omission, whether negligent or not, of Sublessee or any of Sublessee's
agents, servants, employees, contractors, patrons, or invitees (while such
persons are on the Premises) or of any other person entering on the Premises
under or with the expressed or implied invitation of Sublessee, or if any such
injury or damage may in any other way arise from or out of the occupancy or use
of the Premises by Sublessee or Sublessee's agents, employees, and invitees.

9.   Assignment and Subletting; Improvements.

     A.    In accordance with the provisions of Paragraph 11 of the Prime Lease,
no assignment or subletting of the Premises may be made by Sublessee without
Sublessor's and Landlord's prior written consent, which consent may be withheld
by Sublessor or Landlord in their sole discretion. Provided, however, the
Premises may be sublet or assigned to any subsidiary or affiliate of Sublessee
without the requirement of Sublessor's consent, provided that Sublessee remains
fully liable under this Sublease and such sub-sub-lessee or assignee signs an
assumption agreement reasonably satisfactory to Sublessor.

     B.    Notwithstanding the provisions of Paragraph 10 of the Prime Lease
which are incorporated by reference into this Sublease under Section 7 hereof,
                                                             ---------
Sublessee may make the alterations and improvements specified in Exhibit "C"
                                                                 -----------
attached hereto and made a part hereof, which alterations and improvements have
been approved in advance by Sublessor and Landlord. Any such alterations and
improvements shall be made by Sublessee in compliance with all building codes
and other applicable laws. At Sublessor's request, Sublessee shall restore the
Premises to the condition existing prior to the alterations and improvements
specified in Exhibit "C", which restoration shall be conducted in compliance
with all building codes and other applicable laws.

10.  Remedies.

     A.    Sublessor may terminate this Sublease if Sublessee fails to pay any
installment of rent, or other charge or money obligation required to be paid by
Sublessee under this Sublease, within ten (10) days after receipt of written
notice, or fails to perform any other of Sublessee's covenants under this
Sublease within thirty (30) days after receipt of written notice.

     B.    When the Sublease terminates Sublessee will pay, in addition to the
rent and other sums agreed to be paid under this Sublease, any additional sums
as a court may adjudge reasonable as attorney's fees in any suit or action
instituted by Sublessor to enforce the

                                      -5-
<PAGE>

provisions of this Sublease, or the collection of the rent due Sublessor under
this Sublease, provided that Sublessor prevails in the suit or action. Any
property belonging to Sublessee, or to any persons holding by, through, or under
Sublessee, or otherwise found on the Premises, may be removed from the Premises
and stored in any public warehouse at the cost of and for the account of
Sublessee. If Sublessee should abandon, vacate, or surrender the Premises or be
dispossessed by process of law, any personal property left on the Premises may
be deemed abandoned at the option of Sublessor. The provisions of this
Subsection B. are subject to the waiver of subrogation provisions of Section 12.
------------                                                         -----------

     C.    If Sublessee causes a material breach this Sublease, Sublessor may
immediately or at any time thereafter, after notice and ten (10) days
opportunity to cure given to Sublessee (which cure period shall not be required
with respect to an emergency), cure the material breach for the account and at
the expense of Sublessee. If Sublessor at any time, by reason of such material
breach, is compelled to pay, or elects to pay, any sum of money or perform any
act which will require the payment of any sum of money, or is compelled to incur
any expense, including reasonable attorney's fees, in instituting or prosecuting
any action or proceeding to enforce Sublessor's rights under this Sublease, the
sum or sums paid by Sublessor, with interest at the rate of 1% over the prime
rate from the date of payment, will be deemed to be Additional Rent under the
Sublease and will be due from Sublessee to Sublessor on the first day of the
month following the payment of the sums or expense.

     D.    All rights and remedies of Sublessor enumerated in this Sublease are
cumulative and do not exclude any other right or remedy allowed by law, which
may be exercised and enforced concurrently and whenever and as often as the
occasion arises. Should Sublessor be in default under the terms of the Sublease,
Sublessor will have reasonable and adequate time in which to cure the default
after written notice to Sublessor by Sublessee.

     E.    In the event of any legal action between Sublessor and Sublessee to
enforce any of the provisions and/or rights under this Sublease, the
unsuccessful party in the action agrees to pay to the other party all costs and
expenses, including reasonable attorney's fees.

11.  Default by Sublessor.

     A.    If any essential services (such as HVAC, passenger elevators if
necessary for reasonable access, snow removal, etc.) supplied by Sublessor are
interrupted, and the interruption does not result from the negligence or willful
misconduct of Sublessee, its employees, invitees, or agents, Sublessee shall be
entitled to an abatement of Base Rent and Additional Rent during the period of
interruption. Such right shall be construed as an additional remedy granted to
Sublessee and not in limitation of any other rights or remedies which Sublessee
may have.

     B.    If Sublessor defaults in the performance or observance of any
provision of this Lease, Sublessee shall give Sublessor notice specifying in
what manner Sublessor has defaulted and if such default shall not be cured by
Sublessor within 30 days after the delivery of such notice (except that if such
default cannot be cured within said 30 day period, this period shall be extended
for a reasonable additional time, provided that Sublessor commences to cure such

                                      -6-
<PAGE>

default within the 30 day period and proceeds diligently thereafter to effect
such cure) Sublessee may cure such default and/or withhold payment of Base Rent
and Additional Rent due and to accrue hereunder (to the extent necessary to
cover the costs incurred and/or estimated by Sublessee to cure such default) so
long as Sublessor remains in default, or invoice Sublessor for costs and
expenses (including, without limitation, reasonable attorneys' fees and court
costs) incurred by Sublessee therefor. If Sublessee cannot reasonably cure
Sublessor's default or if Sublessor does not reimburse Sublessee within 30 days
of receipt of any invoice for the cost of such cure, Sublessee may terminate
this Lease.

12.  Insurance.

     A.    Sublessor shall keep the Building insured against damage and
destruction by fire, earthquake, vandalism, and other perils in the amount of
the full replacement value of the Building, as the value may exist from time to
time. The insurance shall include an extended coverage endorsement of the kind
required by an institutional lender to repair and restore the Building and shall
name Sublessor as a named insured entitled to notice of cancellation.

     B.    Sublessee, rather than Sublessor, shall maintain contractual and
comprehensive general liability insurance, including public liability and
property damage, of the type and in the amounts specified to be maintained by
Sublessor as Tenant pursuant to Paragraph 12(b) of the Prime Lease.

     C.    Each party waives claims arising in any manner in its (the "Injured
Party") favor and against the other party for loss or damage to Injured Party's
property located within or constituting a part or all of the Building but only
to the extent the loss or damage is covered by the Injured Party's insurance, or
the insurance the Injured Party is required to carry under this Section,
whichever is greater. The waiver also applies to each party's directors,
officers, employees, shareholders, and agents. The waiver does not apply to
claims caused by a party's willful misconduct. Each party shall use all
reasonable efforts to obtain a waiver of subrogation endorsement in the
applicable insurance policies obtained with respect to the Premises.

13.  Quiet Enjoyment; Occupancy.

     A.    Sublessor warrants to Sublessee that it has good right to lease the
Premises to Sublessee, and Sublessor covenants that, provided Sublessee is not
in default under this Lease, Sublessee may occupy, possess and enjoy the
Premises during the Lease Term, without interference from Sublessor or any
person claiming by, from or under Sublessor, including the Landlord under the
Prime Lease.

     B.    Sublessee may, prior to Commencement Date, have unhindered access to
the Premises for the purposes of installing Sublessee's computer and telephone
equipment and otherwise preparing the Premises for Sublessee's occupancy.

14.  Confession of Judgement. Upon the expiration of the then current term of
this Sublease, whether the initial term or a renewal term or the earlier of
termination or surrender

                                      -7-
<PAGE>

hereof, or earlier, upon a default by Sublessee, as provided in this Sublease,
Sublessee hereby authorizes and empowers any prothonotary or attorney of any
court of record in the Commonwealth of Pennsylvania or elsewhere to appear for
Sublessee in any such court and, by complaint or in ejectment against Sublessee
and against all persons claiming through, by or under Sublessee, to therein
confess judgment for the recovery by Sublessor of possession of the Premises,
for which a copy of this Sublease, verified by affidavit, shall be sufficient
warrant; whereupon, if Sublessor so desires, a writ of possession or other
appropriate writ under the rules of civil procedure then in effect may issue
forthwith, without any prior writ or proceedings. Whether this Sublease is
terminated or not and possession of the Premises remains in, or is restored to
Sublessee, Sublessor shall have the right for the same default and upon any
subsequent default or defaults, or upon the termination of this Sublease, to
bring one or more actions to recover possession of the Premises and confess
judgment for recovery of the Premises as provided in this section.

     Sublessee hereby acknowledges that it has had the opportunity to seek the
assistance of legal counsel in the review and execution of this Sublease and
further acknowledges that the meaning and effect of the foregoing provisions
concerning confession of judgment have been fully explained to it by such
counsel.

     Sublessee understands and agrees that this Sublease contains provisions by
which Sublessor may enter judgment by confession against Sublessee. Sublessee
understands that, without these provisions, Sublessee would receive prior notice
and a hearing of any claims by Sublessor before a judgment could be entered.
However, Sublessee hereby freely, knowingly and intelligently waives these
rights and consents to Sublessor entering judgment against it by confession
pursuant to the terms of the Sublease, and acknowledges that upon the entry of
such judgment Sublessor may direct the Sheriff to put the Sublessee out of
possession of the Premises. Sublessee freely, knowingly and intelligently waives
the right to notice and hearing before Sublessor may retake possession of the
Premises pursuant to a confessed judgment and Sublessor may direct the Sheriff
to do so, immediately upon entry of judgment. Sublessee certifies that
Sublessee's annual income exceeds ten thousand ($10,000.00) dollars.

15.  Miscellaneous. This Sublease contains the entire agreement between the
parties on the subject matter hereof, and supersedes all prior agreements and
understandings, oral and/or written. Neither party has relied upon any
representation of any kind which is not specifically set forth herein, and both
parties expressly waive any prospective reliance upon or claim concerning any
omission of fact by any other party. This Sublease may not be changed orally,
but may only be changed by a writing signed by all parties. The invalidity of
all or any part of this Sublease will not render invalid the remainder hereof.
This Sublease will inure to the benefit of, and will be binding upon, the
parties hereto and their respective successors and assigns. This Sublease shall
be governed by and interpreted and enforced in accordance with the laws of the
Commonwealth of Pennsylvania, without regard to conflict of laws provisions. In
the event of litigation relating in any manner to this Sublease, whether its
alleged breach or interpretation, the parties agree to the exclusive
jurisdiction and venue of the courts of Common Pleas of Chester County,
Pennsylvania, sitting in West Chester, Pennsylvania, or if appropriate, the
United States

                                      -8-
<PAGE>

District Court for the Eastern District of Pennsylvania, sitting in
Philadelphia. Time is of the essence in regard to the performance of the duties
and obligations of the parties to this Sublease. The paragraph headings are
inserted for convenience of reference only, are not part of this Sublease, and
shall not be used in its interpretation. This Sublease may be executed in
counterparts, each of which shall be deemed to be an original hereof. The
parties agree to execute and deliver all such other instruments and take all
such other action as any party may reasonably request from time to time, without
payment of further consideration, in order to effectuate the transactions
provided for herein. Any notice which may or must be sent pursuant to this
Sublease shall be sent by certified mail, return receipt requested, or by same
day or overnight courier service, to the parties at their addresses first above
written, unless either party shall have previously provided the other with
notice hereunder of another address.

     IN WITNESS WHEREOF, the parties hereto have executed this Sublease as of
the day and year first above written, and intend to be legally bound hereby.

                                         ENVIRON PRODUCTS, INC.
WITNESS: /s/ Connie Hughes               By: /s/ Michael Webb
        -------------------------------     ------------------------------------

                                         ADOLOR CORPORATION
WITNESS: /s/ Lizanne M. Wentz            By: /s/ Andrew D. Reddick
       --------------------------------     ------------------------------------
          [Intentionally left blank; Landlord's Consent on next page]

                                      -9-
<PAGE>

                               LANDLORD CONSENT
                               ----------------

     The undersigned ("Landlord") is the Landlord under the Prime Lease and in
that capacity hereby consents to this Sublease Agreement (the "Sublease")
between Environ Products, Inc. ("Sublessor") and Adolor Corporation
("Sublessee"). Landlord hereby consents and approves to the alterations and
improvements specified on Exhibit "C" to the Sublease. Landlord specifically
agrees that if Sublessor is not in default under the terms of the Sublease, and
the Prime Lease is for any reason terminated between Landlord and Sublessor,
that Landlord shall not terminate the Sublease, but rather the Sublease shall
continue in accordance with its terms, and be treated by Landlord and Sublessee
as a lease directly between Landlord, as landlord, and Sublessee, as Tenant.
Landlord specifically agrees that Sublessee shall only be responsible for
performing those obligations specifically contained in the Sublease, including
only those obligations specifically incorporated into the Sublease from the
Prime Lease under Paragraph 5 of the Sublease (as same may be limited by the
terms of this Sublease), and Sublessee shall not be responsible for performing
any other obligations of Sublessor, as Tenant, under the Prime Lease. If this
Prime Lease is terminated and the Sublease continues, Landlord shall provide all
the Sublessor Services to Sublessee which were to have been provided by
Sublessor under the Sublease to Sublessee, and further, Landlord shall comply,
for the benefit of Sublessee, with the obligations of Landlord and rights of the
"Tenant" under Paragraphs 7, 9, 14, 15, 16 of the Prime Lease. All capitalized
terms used but not defined in this Landlord Consent shall have the meaning
specified in this Sublease.

                              Landlord:

                              M3 Partners, LP

                              By /s/ Michael Webb
                                --------------------------------
                                     -10-

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