Document:

<PAGE>

                                                                   Exhibit 10.43

                           CYTOKINETICS, INCORPORATED

                              CASH BONUS AGREEMENT

         This Cash Bonus Agreement (the "Agreement") is entered into effective
as of SEPTEMBER 1, 2002 (the "Effective Date"), by and between Cytokinetics,
Incorporated, a Delaware corporation (the "Company"), and Jay Trautman (the
"Employee").

         1.       Cash Bonus. The Company hereby agrees to pay Employee cash
bonuses in the amount of: (i) $13,000, less applicable withholding taxes, on
June 30, 2003, (ii) $13,000, less applicable withholding taxes, on June 30,
2004, (iii) $55,000, less applicable withholding taxes, on June 30, 2005, (iv)
$53,000, less applicable withholding taxes, on June 30, 2006, (v) $51,000, less
applicable withholding taxes, on June 30, 2007 and (vi) $5,000, less applicable
withholding taxes, on June 30, 2008 (collectively, the "Cash Bonus"), provided
that Employee remains an employee in good standing of the Company, as determined
in the Company's sole discretion, on each such date.

         2.       No Right To Continued Employment. Nothing contained herein
shall be construed to confer on Employee any right to continued employment with
the Company. The Company or Employee may terminate the employment relationship
of Employee with the Company for any reason or no reason, with or without cause,
and after such termination Employee shall not have any right to receive any
further payments of Cash Bonus remaining unpaid at such time.

         3.       Taxes. Employee shall be responsible for all taxes related to
the Cash Bonus.

         4.       Integration; No Assignment. This Agreement represents the
entire agreement and understanding between the parties as to the Cash Bonus, and
supersedes all prior or contemporaneous agreements whether written or oral;
provided, however, that this Agreement is meant to be in addition to any other
compensation arrangements Employee may have with the Company. No waiver,
alteration, or modification of any of the provisions of this Agreement shall be
binding unless in writing and signed by the parties hereto or their duly
authorized representatives. Neither this Agreement nor any rights of Employee
hereunder may be assigned or transferred by Employee.

         5.       Applicable Law. This Agreement shall be governed by and
construed in accordance with the internal substantive laws, but not the choice
of law rules, of the State of California.

<PAGE>

         IN WITNESS WHEREOF, each of the parties has executed this Agreement, in
the case of the Company by its duly authorized officer, as of the day and year
first above written.

                                       CYTOKINETICS, INCORPORATED

                                       By: /s/ James Sabry
                                           -------------------------------------
                                       Title:
                                              ----------------------------------
                                       EMPLOYEE

                                                  /s/ Jay Trautman
                                       -----------------------------------------
                                       Signature

                                                    Jay Trautman
                                       -----------------------------------------
                                       Name

                                      -2-<PAGE>

                                                                   Exhibit 10.44

                           CYTOKINETICS, INCORPORATED

                    AMENDED AND RESTATED CASH BONUS AGREEMENT

         This Amended and Restated Cash Bonus Agreement (the "Agreement") is
entered into effective as of December 1, 2003 (the "Effective Date"), by and
between Cytokinetics, Incorporated, a Delaware corporation (the "Company"), and
Jay Trautman (the "Employee")

         WHEREAS the Company and the Employee entered into a Cash Bonus
Agreement dated as of September 1, 2002 (the "Prior Agreement"); and

         WHEREAS the Company and the Employee desire to amend and restated the
Prior Agreement in its entirety with this Agreement.

         NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the Company and the Employee hereby
agree as follows:

         1.       Amendment and Restatement. The Company and the Employee hereby
amend and restate the Prior Agreement in its entirety with this Agreement.

         2.       Cash Bonus. The Company hereby agrees to pay Employee cash
bonuses in the amount of: (i) $19,300, less applicable withholding taxes, on
December 15, 2003, (ii) $19,300 less applicable withholding taxes, on June 30,
2004, (iii) $86,200, less applicable withholding taxes, on June 30, 2005 (iv)
$82,300, less applicable withholding taxes, on June 30, 2006, (v) $78,500, less
applicable withholding taxes, on June 30, 2007 and (vi) $7,700, less applicable
withholding taxes, on June 30, 2008 (collectively, the "Cash Bonus"), provided
that Employee remains an employee in good standing of the Company, as determined
in the Company's sole discretion, on each such date.

         3.       No Right To Continued Employment. Nothing contained herein
shall be construed to confer on Employee any right to continued employment with
the Company. The Company or Employee may terminate the employment relationship
of Employee with the Company for any reason or no reason, with or without cause,
and after such termination Employee shall not have any right to receive any
further payments of Cash Bonus remaining unpaid at such time.

         4.       Taxes. Employee shall be responsible for all taxes related to
the Cash Bonus.

         5.       Integration; No Assignment. This Agreement represents the
entire agreement and understanding between the parties as to the Cash Bonus, and
supersedes all prior or contemporaneous agreements, including, without
limitation, the Prior Agreement, whether written or oral; provided, however,
that this Agreement is meant to be in addition to any other compensation
arrangements Employee may have with the Company. No waiver, alteration, or
modification of any of the provisions of this Agreement shall be binding unless
in writing and signed by the parties hereto or their duly authorized
representatives. Neither this Agreement nor any rights of Employee hereunder may
be assigned or transferred by Employee.

<PAGE>

         6.       Applicable Law. This Agreement shall be governed by and
construed in accordance with the internal substantive laws, but not the choice
of law rules, of the State of California.

                [remainder of this page intentionally left blank]

                                      -2-

<PAGE>

         IN WITNESS WHEREOF, each of the parties has executed this Agreement, in
the case of the Company by its duly authorized officer, as of the day and year
first above written.

                                       CYTOKINETICS, INCORPORATED

                                       By: _____________________________________

                                       Title: __________________________________

                                       EMPLOYEE

                                       _________________________________________
                                       Signature

                                       _________________________________________
                                       Name

                                      -3-Exhibit 4.1(b)

 

EXHIBIT 4.1(b)

SUPPLEMENT NO. 1 TO INDENTURE

     This SUPPLEMENT NO. 1 TO INDENTURE (this “Supplement”) is entered into as
of January    , 2004, by and between Onyx Acceptance Corporation, a Delaware
corporation (the “Company”), as obligor, and U.S. Bank National Association, a
national banking association, as trustee (the “Trustee”).

     The Company and the Trustee agree as follows for the benefit of each other
and for the equal and ratable benefit of the Holders of the renewable,
unsecured, subordinated debt securities of the Company issued pursuant to the
Company’s registration statement on Form S-3 declared effective by the
Securities and Exchange Commission on or about January    , 2004 (the
"Registration Statement”):

     WHEREAS, the Company and the Trustee entered into that certain Indenture
dated as of the February 11, 2002 (the “Original Indenture”), pursuant to which
the Trustee agreed to act as Trustee in connection with the issuance by the
Company of $50,000,000 aggregate principal amount of unsecured subordinated
renewable notes (the “Original Notes”);

     WHEREAS, the Company has authorized and proposes to issue up to an
additional $50,000,000 aggregate principal amount of its unsecured subordinated
renewable notes (the “Additional Notes” and, together with the Original Notes,
the “Notes”);

     WHEREAS, the Company and the Trustee desire to supplement the Original
Indenture with this Supplement (as supplemented, the “Indenture”) to allow for
the issuance of the Additional Notes subject to the terms and conditions of the
Original Indenture;; and

     WHEREAS, Section 9.1(c) of the Original Indenture permits an amendment to
the Original Indenture by the Company and the Trustee without the consent of
any Holder “to provide for additional uncertificated Securities or certificated
Securities;”

     NOW, THEREFORE, in consideration of the mutual agreements hereinafter
contained, the Company and the Trustee hereby covenant and agree as follows:

ARTICLE I

DEFINITIONS

     Section 1.1 The parties hereto agree and acknowledge that, effective as of
the date hereof, the following terms, as used and defined in the Original
Indenture, shall have the definitions set forth below for all purposes of the
Original Indenture and this Supplement:

     “Indenture” shall mean the indenture dated as of February 11, 2002 between
the Issuer and U.S. Bank National Association, as trustee, as supplemented by
Supplement No. 1 to Indenture, dated as of January    , 2004.

     “Notes” shall mean the Original Notes together with the Additional Notes.

 

 

     "Registration Statement” shall mean the Company’s registration statement
on Form S-3, as amended, declared effective by the Securities and Exchange
Commission on or about January    , 2004.

ARTICLE II

THE SECURITIES

     Section 2.1 To allow for the issuance of the Additional Notes, the first
sentence of Section 2.1(a) of the Original Indenture is hereby amended and
restated in its entirety as follows:

     The outstanding aggregate principal amount of Securities to be issued
hereunder (absent an amendment to the Registration Statement) is limited to
$100 million; provided, however, that the Company and the Trustee may,
without the consent of any Holder, increase such aggregate principal amount
of Securities which may be outstanding at any time.

ARTICLE III

MISCELLANEOUS

     Section 3.1 Capitalized terms used and not otherwise defined herein have
the meanings set forth in the Original Indenture.

     Section 3.2 The terms and provisions set forth in this Supplement shall
modify and supersede all inconsistent terms and provisions set forth in the
Original Indenture and, except as expressly modified and superseded by this
Supplement, the terms and provisions of the Original Indenture are ratified and
confirmed and shall continue in full force and effect. The Indenture and this
Supplement shall be read, taken and construed as one and the same instrument.

     Section 3.3 This Supplement may be executed in any number of counterparts,
each of which when so executed shall be deemed to be an original, but all of
such counterparts shall together constitute but one and the same instrument.

     Section 3.4 THE INTERNAL LAW OF THE STATE OF NEW YORK SHALL GOVERN THIS
SUPPLEMENT, WITHOUT REGARD TO THE CONFLICT OF LAWS PROVISIONS THEREOF.

[signatures begin on next page]

 

 

     IN WITNESS WHEREOF, the parties hereto have caused to be duly executed,
and their respective corporate seals to be affixed and attested unto, as of the
day and year first written above, this SUPPLEMENT NO. 1 TO INDENTURE.

	 	 	 	 	 
	 	 	ONYX ACCEPTANCE CORPORATION
	 	 	 	 	 
	 	 	
By:	 	 
	 	 	 	 	

	 	 	
Name:	 	 
	 	 	 	 	

	 	 	
Title:	 	 
	 	 	 	 	

	 	 	 	 	 
	 	 	U.S. BANK NATIONAL ASSOCIATION, a

national banking association, as Trustee
	 	 	 	 	 
	 	 	
By:	 	 
	 	 	 	 	

	 	 	
Name:	 	 
	 	 	 	 	

	 	 	
Title:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00060-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00060-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00060-of-00352.parquet"}]]