Document:

EX-10.11

 Exhibit 10.11 

EMPLOYMENT AGREEMENT 
 THIS
EMPLOYMENT AGREEMENT (the “Agreement”), is made as of August 28, 2018 by and between Arvinas, Inc. (the “Company”), and Andrew Crew (the “Executive”) (together, the “Parties”). 

RECITALS 
 WHEREAS, the Company
desires to employ the Executive as its Senior Vice President, Chemistry; and 
 WHEREAS, the Executive has agreed to accept such employment
on the terms and conditions set forth in this Agreement; 
 NOW, THEREFORE, in consideration of the foregoing and of the respective
covenants and agreements of the Parties herein contained, the Parties hereto agree as follows: 
 1. Agreement. This Agreement shall be effective as
of the date on which the registration statement relating to the Company’s initial public offering (the “Offering”) is effective (the “Effective Date”). Following the Effective Date, the Executive shall continue to be an
employee of the Company until such employment relationship is terminated in accordance with Section 7 hereof (the “Term of Employment”). 

2. Position. During the Term of Employment, the Executive shall serve as the Senior Vice President, Chemistry of the Company, working out of the
Company’s office in New Haven, Connecticut, and travelling as reasonably required by the Executive’s job duties. 
 3. Scope of Employment.
During the Term of Employment, the Executive shall be responsible for the performance of those duties consistent with the Executive’s position as Senior Vice President, Chemistry. The Executive shall report to the Chief Executive Officer of the
Company and/or the Company’s board of directors (the “Board”) and shall perform and discharge faithfully, diligently, and to the best of the Executive’s ability, the Executive’s duties and responsibilities hereunder. The
Executive shall devote substantially all of the Executive’s business time, loyalty, attention and efforts to the business and affairs of the Company and its affiliates. Membership on boards of directors of any other companies will be permitted
only with the express approval of the Board; provided, however, that the Executive may engage in community and charitable activities or participate in industry associations and serve on the boards of up to two (2) community, charitable or
industry organizations, without the approval of the Board, provided such activities do not create a conflict of interest or otherwise interfere with the Executive’s performance of the Executive’s duties hereunder. The Executive agrees to
abide by the rules, regulations, instructions, personnel practices and policies of the Company and any changes therein that may be adopted from time to time by the Company. 

  
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 4. Compensation. As full compensation for all services rendered by the Executive to the Company and any
affiliate thereof, during the Term of Employment, the Company will provide to the Executive the following: 
 (a) Base Salary.
Effective as of the Effective Date, the Executive shall receive a base salary at the annualized rate of $300,000 (the “Base Salary”). The Executive’s Base Salary shall be paid in equal installments in accordance with the
Company’s regularly established payroll procedures. The Executive’s Base Salary will be reviewed on an annual or more frequent basis by the Board and is subject to change in the discretion of the Board. 

(b) Annual Discretionary Bonus. Effective as of the Effective Date, the Executive will be eligible to earn an annual performance bonus
of up to 35% of the Executive’s Base Salary (the “Target Bonus”), based upon the Board’s assessment of the Executive’s performance and the Company’s attainment of targeted goals as set by the Board in its sole
discretion. To the extent the Executive’s Base Salary is changed during the year to which the performance bonus relates, the Target Bonus shall be calculated based on base salary actually paid during such year (and not solely on the
Executive’s Base Salary at the end of such year). The Board may determine to provide the bonus in the form of cash, equity award(s), or a combination of cash and equity. Following the close of each calendar year, the Board will determine
whether the Executive has earned a performance bonus, and the amount of any performance bonus, based on the set criteria. No amount of the annual bonus is guaranteed, and the Executive must be an employee in good standing on the date of payment in
order to be eligible for any annual bonus, except as specifically set forth below. The annual performance bonus, if earned, will be paid by no later than March 15 of the calendar year after the year to which it relates. The Executive’s
bonus eligibility will be reviewed on an annual or more frequent basis by the Board and is subject to change in the discretion of the Board. 

(c) Equity Award. The Executive will be eligible to receive equity awards, if any, at such times and on such terms and conditions as
the Board shall, in its sole discretion, determine. 
 (d) Paid Time Off. The Executive shall receive fifteen (15) days per
annum of paid time off vacation time plus sick time, consistent with the Company’s policies, during each full year of employment with the Company (allocated ratably for any partial year worked by the Executive) that must be used in accordance
with the Company’s paid time off policies as in effect from time to time. 
 (e) Benefits. Subject to eligibility requirements
and the Company’s polices, you shall have the right, on the same basis as other employees of the Company, to participate in, and to receive benefits under, any medical, vision and dental insurance policy maintained by the Company and the
Company shall pay a portion of the cost of the premiums for such medical, vision and dental insurance that is consistent with the Company’s then current employee benefit policy if you elect to participate in such plans. 

(f) Withholdings. All compensation payable to the Executive shall be subject to applicable taxes and withholdings. 

5. Expenses. The Executive will be reimbursed for his actual, necessary and reasonable business expense pursuant to Company policy, subject to the
provisions of Section 3 of Exhibit A attached hereto. 

  
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 6. Restrictive Covenants Agreement. The Executive hereby acknowledges that in connection with entering
into this agreement, he shall be required to enter into a new Proprietary Rights, Non-Disclosure, Developments, Non-Competition, and
Non-Solicitation Agreement. 
 7. Employment Termination. This Agreement and the employment of the Executive
shall terminate upon the occurrence of any of the following: 
 (a) Upon the death or “Disability” of the Executive. As used in
this Agreement, the term “Disability” shall mean a physical or mental illness or disability that prevents the Executive from performing the duties of the Executive’s position for a period of more than any three consecutive months or
for periods aggregating more than twenty-six weeks. The Company shall determine in good faith and in its sole discretion whether the Executive is unable to perform the services provided for herein. 

(b) At the election of the Company, with or without “Cause” (as defined below), immediately upon written notice by the Company to
the Executive. As used in this Agreement, “Cause” shall mean a finding by the Company’s Chief Executive Officer or the Board that the Executive: 
  

	 	(i)	 performed his duties, in the good faith opinion of the Company’s Chief Executive Officer or the Board, in
a grossly negligent or reckless manner or with willful malfeasance; 

  

	 	(ii)	 exhibited habitual drunkenness or engaged in substance abuse; 

 

	 	(iii)	 committed any material violation of any state or federal law relating to the workplace environment (including,
without limitation, laws relating to sexual harassment or age, sex or other prohibited discrimination) or any material violation of any Company policy; 

  

	 	(iv)	 willfully failed or refused to perform in the usual manner at the usual time those duties which he regularly
and routinely performed in connection with the business of the Company or such other duties reasonably related to the capacity in which the Executive is employed hereunder which may be assigned to the Executive by the Company’s Chief Executive
Officer or the Board; 

  

	 	(v)	 performed any material action when specifically and reasonably instructed not to do so by the Company’s
Chief Executive Officer or the Board; 

  

	 	(vi)	 breached the Executive’s Proprietary Rights, Non-Disclosure,
Developments, Non-Competition, and Non-Solicitation Agreement or any similar agreement with the Company; 

 

	 	(vii)	 committed any fraud or used or appropriated for his personal use or benefit any funds, properties or
opportunities of the Company not authorized by the Company’s Chief Executive Officer or the Board to be so used or appropriated; or 

  
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	 	(viii)	 was convicted of any felony or any other crime related to the Executive’s employment or involving moral
turpitude. 

 (c) At the election of the Executive, with or without “Good Reason” (as defined below),
immediately upon written notice by the Executive to the Company (subject, if it is with Good Reason, to the timing provisions set forth in the definition of Good Reason). As used in this Agreement, “Good Reason” shall mean (without the
Executive’s consent): 
  

	 	(i)	 a material diminution in the nature or scope of Executive’s duties, responsibilities, or authority;

  

	 	(ii)	 a material diminution of the Executive’s base compensation; 

 

	 	(iii)	 the Company’s requiring Executive to relocate Executive’s primary office more than fifty
(50) miles from the Executive’s then-current primary office; or 

  

	 	(iv)	 any material breach of this Agreement by the Company not otherwise covered by this paragraph;

 provided, however, that in each case, the Company shall have a period of not less than thirty (30) days to cure any act
constituting Good Reason following Executive’s delivery to the Company of written notice within sixty (60) days of the action or omission constituting Good Reason and that the Executive actually terminates employment within thirty
(30) days following the expiration of the Company’s cure period. 
 8. Effect of Termination. 

(a) All Terminations Other Than by the Company Without Cause or by the Executive With Good Reason. If the Executive’s employment
is terminated under any circumstances other than a Qualifying Termination (as defined below) (including a voluntary termination by the Executive without Good Reason pursuant to Section 7(c), a termination by the Company for Cause pursuant to
Section 7(b) or due to the Executive’s death or Disability pursuant to Section 7(a)), the Company’s obligations under this Agreement shall immediately cease and the Executive shall only be entitled to receive (i) the Base
Salary that has accrued and to which the Executive is entitled as of the effective date of such termination and to the extent consistent with general Company policy, accrued but unused paid time off through and including the effective date of such
termination, to be paid in accordance with the Company’s established payroll procedure and applicable law but no later than the next regularly scheduled pay period, (ii) unreimbursed business expenses for which expenses the Executive has
timely submitted appropriate documentation in accordance with Section 5 hereof, and (iii) any amounts or benefits to which the Executive is then entitled under the terms of the benefit plans then-sponsored by the Company in accordance with
their terms (and not accelerated to the extent acceleration does not satisfy Section 409A of the Internal Revenue Code of 1986, as amended, (the “Code”) (the payments described in this sentence, the “Accrued Obligations”).

  
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 (b) Termination by the Company Without Cause or by the Executive With Good Reason Prior to or
More Than Twelve Months Following a Change in Control. If the Executive’s employment is terminated by the Company without Cause pursuant to Section 7(b) or by the Executive with Good Reason pursuant to Section 7(c) (in either
case, a “Qualifying Termination”) prior to or more than twelve (12) months following a Change in Control (as defined below), the Executive shall be entitled to the Accrued Obligations. In addition, and subject to Exhibit A and
the conditions of Section 8(d), the Company shall: (i) continue to pay to the Executive, in accordance with the Company’s regularly established payroll procedures, the Executive’s Base Salary for a period of nine (9) months
and (ii) provided the Executive is eligible for and timely elects to continue receiving group medical insurance pursuant to the “COBRA” law, continue to pay (but in no event longer than nine (9) months following the
Executive’s termination date) the share of the premium for health coverage that is paid by the Company for active and similarly-situated employees who receive the same type of coverage, unless the Company’s provision of such COBRA payments
will violate the nondiscrimination requirements of applicable law, in which case this benefit will not apply (collectively, the “Severance Benefits”). 

(c) Termination by the Company Without Cause or by the Executive With Good Reason Within Twelve Months Following a Change in Control.
If a Qualifying Termination occurs within twelve (12) months following a Change in Control, then the Executive shall be entitled to the Accrued Obligations. In addition, and subject to Exhibit A and the conditions of Section 8(d),
the Company shall: (i) continue to pay to the Executive, in accordance with the Company’s regularly established payroll procedures, the Executive’s Base Salary for a period of twelve (12) months; (ii) pay to the Executive, in a
single lump sum on the Payment Date (as defined below) an amount equal to 100% of the Executive’s Target Bonus for the year in which termination occurs or, if higher, the Executive’s Target Bonus immediately prior to the Change in Control,
(iii) provided the Executive is eligible for and timely elects to continue receiving group medical insurance pursuant to the “COBRA” law, continue to pay (but in no event longer than twelve (12) months following the
Executive’s termination date) the share of the premium for health coverage that is paid by the Company for active and similarly-situated employees who receive the same type of coverage, unless the Company’s provision of such COBRA payments
will violate the nondiscrimination requirements of applicable law, in which case this benefit will not apply, and (iv) provide that the vesting of the Executive’s then-unvested equity awards shall be accelerated, such that all
then-unvested equity awards vest and become fully exercisable or non-forfeitable as of the termination date (collectively, the “Change in Control Severance Benefits”). 

(d) Release. As a condition of the Executive’s receipt of the Severance Benefits or the Change in Control Severance Benefits, as
applicable, the Executive must execute and deliver to the Company a severance and release of claims agreement in a form to be provided by the Company (the “Severance Agreement”), which Severance Agreement must become irrevocable within 60
days following the date of the Executive’s termination of employment (or such shorter period as may be directed by the Company). The Severance Benefits or the Change in Control Severance Benefits, as applicable, will be paid or commence to be
paid in the first regular payroll beginning after the Severance Agreement becomes effective, provided that if the foregoing 60 day period would end in a calendar year subsequent to the year in which the Executive’s employment ends, the
Severance Benefits or Change in Control Severance Benefits, as applicable, will not be paid or begin to be paid before the first payroll of the subsequent calendar year (the date the Severance Benefits or Change in Control Severance Benefits, as
applicable, commence pursuant to this sentence, the “Payment Date”). The Executive must continue to comply with the Proprietary Rights, Non-Disclosure, Developments,
Non-Competition, and Non-Solicitation Agreement and any similar agreement with the Company in order to be eligible to continue receiving the Severance Benefits or Change
in Control Severance Benefits, as applicable. 

  
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 (e) Change in Control Definition. For purposes of this Agreement, “Change in
Control” shall mean the occurrence of any of the following events, provided that such event or occurrence constitutes a change in the ownership or effective control of the Company, or a change in the ownership of a substantial portion of the
assets of the Company, as defined in Treasury Regulation §§1.409A-3(i)(5)(v), (vi) and (vii): (i) the acquisition by an individual, entity or group (within the meaning of Section 13(d)(3) or
14(d)(2) of the Securities Exchange Act of 1934 (the “Exchange Act”)) (a “Person”) of beneficial ownership of any capital stock of the Company if, after such acquisition, such Person beneficially owns (within the meaning of Rule 13d-3 under the Exchange Act) fifty percent (50%) or more of either (x) the then-outstanding shares of common stock of the Company (the “Outstanding Company Common Stock”) or (y) the combined
voting power of the then-outstanding securities of the Company entitled to vote generally in the election of directors (the “Outstanding Company Voting Securities”); provided, however, that for purposes of this subsection (i), the
following acquisitions shall not constitute a Change in Control: (1) any acquisition directly from the Company or (2) any acquisition by any entity pursuant to a Business Combination (as defined below) which complies with clauses
(x) and (y) of subsection (iii) of this definition; or (ii) a change in the composition of the Board that results in the Continuing Directors (as defined below) no longer constituting a majority of the Board (or, if applicable, the
Board of Directors of a successor corporation to the Company), where the term “Continuing Director” means at any date a member of the Board (x) who was a member of the Board on the Effective Date or (y) who was nominated or
elected subsequent to such date by at least a majority of the directors who were Continuing Directors at the time of such nomination or election or whose election to the Board was recommended or endorsed by at least a majority of the directors who
were Continuing Directors at the time of such nomination or election; provided, however, that there shall be excluded from this clause (y) any individual whose initial assumption of office occurred as a result of an actual or threatened
election contest with respect to the election or removal of directors or other actual or threatened solicitation of proxies or consents, by or on behalf of a person other than the Board; or (iii) the consummation of a merger, consolidation,
reorganization, recapitalization or share exchange involving the Company, or a sale or other disposition of all or substantially all of the assets of the Company (a “Business Combination”), unless, immediately following such Business
Combination, each of the following two (2) conditions is satisfied: (x) all or substantially all of the individuals and entities who were the beneficial owners of the Outstanding Company Common Stock and Outstanding Company Voting
Securities immediately prior to such Business Combination beneficially own, directly or indirectly, more than fifty percent (50%) of the then-outstanding shares of common stock and the combined voting power of the then-outstanding securities
entitled to vote generally in the election of directors, respectively, of the resulting or acquiring corporation in such Business Combination (which shall include, without limitation, a corporation which as a result of such transaction owns the
Company or substantially all of the Company’s assets either directly or through one (1) or more subsidiaries) (such resulting or acquiring corporation is referred to herein as the “Acquiring Corporation”) in substantially the
same proportions as their ownership of the Outstanding Company Common Stock and Outstanding Company Voting Securities, respectively, immediately prior to such Business Combination and (y) no Person (excluding any employee benefit plan (or
related trust) maintained or sponsored by 

  
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the Company or by the Acquiring Corporation) beneficially owns, directly or indirectly, fifty percent (50%) or more of the then-outstanding shares of common stock of the Acquiring Corporation, or
of the combined voting power of the then-outstanding securities of such corporation entitled to vote generally in the election of directors (except to the extent that such ownership existed prior to the Business Combination); or (iv) the
liquidation or dissolution of the Company. 
 9. Absence of Restrictions. The Executive represents and warrants that the Executive is not bound by
any employment contracts, restrictive covenants or other restrictions that prevent the Executive from entering into employment with, or carrying out the Executive’s responsibilities for, the Company, or which are in any way inconsistent with
any of the terms of this Agreement. 
 10. Notice. Any notice delivered under this Agreement shall be deemed duly delivered three (3) business
days after it is sent by registered or certified mail, return receipt requested, postage prepaid, one (1) business day after it is sent for next-business day delivery via a reputable nationwide overnight courier service, or immediately upon
hand delivery, in each case to the address of the recipient set forth below. 
 To Executive: 

At the address set forth in the Executive’s personnel file 

To Company: 
 Arvinas, Inc. 

5 Science Park 
 New Haven, CT
06511 
 Either Party may change the address to which notices are to be delivered by giving notice of such change to the other Party in the manner set forth
in this Section 10. 
 11. Applicable Law; Jury Trial Waiver. This Agreement shall be governed by and construed in accordance with the laws of
the State of Connecticut (without reference to the conflict of laws provisions thereof). Any action, suit or other legal proceeding arising under or relating to any provision of this Agreement shall be commenced only in a court of the State of
Connecticut (or, if appropriate, a federal court located within the State of Connecticut), and the Company and the Executive each consents to the jurisdiction of such a court. The Company and the Executive each hereby irrevocably waives any right to
a trial by jury in any action, suit or other legal proceeding arising under or relating to any provision of this Agreement. 
 12. Successors and
Assigns. This Agreement shall be binding upon and inure to the benefit of both Parties and their respective successors and assigns, including any corporation with which or into which the Company may be merged or which may succeed to its assets
or business; provided, however, that the obligations of the Executive are personal and shall not be assigned by the Executive. 
 13. At-Will Employment. During the Term of Employment, the Executive will continue to be an at-will employee of the Company, which means that, notwithstanding any other
provision set forth herein, the employment relationship can be terminated by either Party for any reason, at any time, with or without prior notice and with or without Cause. 

  
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 14. Acknowledgment. The Executive states and represents that the Executive has had an opportunity to fully
discuss and review the terms of this Agreement with an attorney. The Executive further states and represents that the Executive has carefully read this Agreement, understands the contents herein, freely and voluntarily assents to all of the terms
and conditions hereof, and signs the Executive’s name of the Executive’s own free act. 
 15. No Oral Modification, Waiver, Cancellation or
Discharge. This Agreement may be amended or modified only by a written instrument executed by both the Company and the Executive. No delay or omission by the Company in exercising any right under this Agreement shall operate as a waiver of that
or any other right. A waiver or consent given by the Company on any one occasion shall be effective only in that instance and shall not be construed as a bar to or waiver of any right on any other occasion. 

16. Captions and Pronouns. The captions of the sections of this Agreement are for convenience of reference only and in no way define, limit or affect
the scope or substance of any section of this Agreement. Whenever the context may require, any pronouns used in this Agreement shall include the corresponding masculine, feminine or neuter forms, and the singular forms of nouns and pronouns shall
include the plural, and vice versa. 
 17. Interpretation. The Parties agree that this Agreement will be construed without regard to any presumption
or rule requiring construction or interpretation against the drafting Party. References in this Agreement to “include” or “including” should be read as though they said “without limitation” or equivalent forms.
References in this Agreement to the “Board” shall include any authorized committee thereof. 
 18. Severability. Each provision of this
Agreement must be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be prohibited by or invalid under applicable law, such provision will be ineffective only to the extent
of such prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Agreement. Moreover, if a court of competent jurisdiction determines any of the provisions contained in this Agreement to be
unenforceable because the provision is excessively broad in scope, whether as to duration, activity, geographic application, subject or otherwise, it will be construed, by limiting or reducing it to the extent legally permitted, so as to be
enforceable to the extent compatible with then applicable law to achieve the intent of the Parties. 
 19. Entire Agreement. This Agreement
constitutes the entire agreement between the Parties and supersedes all prior agreements and understandings, whether written or oral, relating to the subject matter of this Agreement. 

[Signatures on Page Following] 

  
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 IN WITNESS WHEREOF, the Parties hereto have executed this Agreement as of the day and year set forth above. 

ARVINAS, INC.     
 By:
/s/ John Houston                                 

Name: John
Houston                    

Title: Chief Executive Officer and President      

EXECUTIVE:                 

/s/ Andrew Crew
                                 

Andrew Crew 

  
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 EXHIBIT A 

Payments Subject to Section 409A 

1.    Subject to this Exhibit A, any severance payments that may be due under the Agreement shall begin only upon the date
of the Executive’s “separation from service” (determined as set forth below) which occurs on or after the termination of the Executive’s employment. The following rules shall apply with respect to distribution of the severance
payments, if any, to be provided to the Executive under the Agreement, as applicable: 
 (a)    It is
intended that each installment of the severance payments provided under the Agreement shall be treated as a separate “payment” for purposes of Section 409A of the Internal Revenue Code (“Section 409A”). Neither the
Company nor the Executive shall have the right to accelerate or defer the delivery of any such payments except to the extent specifically permitted or required by
Section 409A.                 

(b)    If, as of the date of the Executive’s “separation from service” from the Company, the
Executive is not a “specified employee” (within the meaning of Section 409A), then each installment of the severance payments shall be made on the dates and terms set forth in the letter agreement. 

(c)    If, as of the date of the Executive’s “separation from service” from the Company, the
Executive is a “specified employee” (within the meaning of Section 409A), then: 
  

	 	(i)	 Each installment of the severance payments due under the Agreement that, in accordance with the dates and terms
set forth herein, will in all circumstances, regardless of when the Executive’s separation from service occurs, be paid within the short-term deferral period (as defined under Section 409A) shall be treated as a short-term deferral within
the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible under Section 409A and shall be paid on the dates and terms set forth in the Agreement; and

  

	 	(ii)	 Each installment of the severance payments due under the Agreement that is not described in this Exhibit A,
Section 1(c)(i) and that would, absent this subsection, be paid within the six-month period following the Executive’s “separation from service” from the Company shall not be paid until the
date that is six months and one day after such separation from service (or, if earlier, your death), with any such installments that are required to be delayed being accumulated during the six-month period and
paid in a lump sum on the date that is six months and one day following the Executive’s separation from service and any subsequent installments, if any, being paid in accordance with the dates and terms set forth herein; provided, however, that
the preceding provisions of this sentence shall not apply to any installment of payments if and to the maximum extent that that such installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by
reason of the application of Treasury Regulation 1.409A-1(b)(9)(iii) (relating to separation pay upon an involuntary separation from service). Any installments that qualify for the exception under Treasury
Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than the last day of the Executive’s second taxable year following the taxable year in which the separation from service occurs.

  
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 2.    The determination of whether and when the Executive’s separation
from service from the Company has occurred shall be made and in a manner consistent with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1(h). Solely for purposes of
Section 2 of this Exhibit A, “Company” shall include all persons with whom the Company would be considered a single employer under Section 414(b) and 414(c) of the Code. 

3.    All reimbursements and in-kind benefits provided under the Agreement shall
be made or provided in accordance with the requirements of Section 409A to the extent that such reimbursements or in-kind benefits are subject to Section 409A, including, where applicable, the
requirements that (i) any reimbursement is for expenses incurred during the Executive’s lifetime (or during a shorter period of time specified in the Agreement), (ii) the amount of expenses eligible for reimbursement during a calendar year
may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is incurred
and (iv) the right to reimbursement is not subject to set off or liquidation or exchange for any other benefit. 

4.    The Company makes no representation or warranty and shall have no liability to the Executive or to any other person
if any of the provisions of the Agreement (including this Exhibit A) are determined to constitute deferred compensation subject to Section 409A but that do not satisfy an exemption from, or the conditions of, that section. 

5.    The Agreement is intended to comply with, or be exempt from, Section 409A and shall be interpreted accordingly.

 [Remainder of page intentionally left blank.] 

  
 11EX-10.12

 Exhibit 10.12 

LEASE 
 BETWEEN 

SCIENCE PARK DEVELOPMENT CORPORATION 

AND 
 ARVINAS, INC.

 DATE:     December 31, 2017 

 TABLE OF CONTENTS 

 

					
	Article No.  Description	  	Page	 
		
	 1. LEASED PREMISES
	  	 	1	 
	 2. TERM
	  	 	2	 
	 3. RENT
	  	 	5	 
	 4. TAXES
	  	 	10	 
	 5. TENANT’S USE OF LEASED PREMISES
	  	 	11	 
	 6. ALTERATIONS
	  	 	11	 
	 7. REPAIRS
	  	 	13	 
	 8. COMPLIANCE WITH LAWS; INCREASED INSURANCE RATES; ENVIRONMENTAL LAWS
	  	 	14	 
	 9. FLOOR LOAD; MACHINERY AND EQUIPMENT
	  	 	17	 
	 10. TENANT’S OBLIGATIONS TO LANDLORD S LENDERS
	  	 	17	 
	 11. LIMITATIONS ON LANDLORD’S LIABILITY
	  	 	18	 
	 12. TENANT’S OBLIGATION TO PROTECT LANDLORD AND LANDLORD’S LENDERS
	  	 	19	 
	 13. FIRE AND OTHER CASUALTY
	  	 	20	 
	 14. TAKING BY GOVERNMENTAL AUTHORITY
	  	 	21	 
	 15. TENANT’S RIGHT TO ENCUMBER, ASSIGN, OR SUBLEASE
	  	 	22	 
	 16. ACCESS TO LEASED PREMISES
	  	 	23	 
	 17. DEFAULT AND TERMINATION
	  	 	24	 
	 18. LANDLORD S PERFORMANCE ON TENANT’S BEHALF
	  	 	27	 
	 19. TENANT’S QUIET ENJOYMENT OF THE LEASED PREMISES
	  	 	27	 
	 20. NO WAIVER BY LANDLORD
	  	 	27	 
	 21. INABILITY TO PERFORM
	  	 	27	 
	 22. NOTICES AND OTHER COMMUNICATIONS
	  	 	28	 
	 23. RULES AND REGULATIONS
	  	 	28	 
	 24. SECURITY DEPOSIT
	  	 	29	 
	 25. INSURANCE
	  	 	30	 
	 26. SERVICES PROVIDED BY LANDLORD
	  	 	31	 
	 27. ADDITIONAL OBLIGATIONS OF TENANT
	  	 	32	 
	 28. SIGNS
	  	 	33	 
	 29. BROKERAGE
	  	 	33	 
	 30. NOTICE OF LEASE
	  	 	33	 
	 31. SURRENDERING OF LEASED PREMISES
	  	 	33	 
	 32. ADDITIONAL OBLIGATIONS OF TENANT
	  	 	34	 
	 33. TENANT’S WAIVER OF RIGHTS
	  	 	34	 
	 34. EFFECT OF WRITTEN LEASE AGREEMENT
	  	 	35	 
	 35. OPTION TO EXTEND
	  	 	36	 
	 36. INTERPRETATION OF LEASE; MISCELLANEOUS
	  	 	37	 

  
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 Exhibits 
  

			
	Exhibit A	  	Legal Property Description — 395 Winchester Avenue
	Exhibit B	  	Holidays

 Schedules 
  

			
	A-1	  	Floor Plan of First Floor Premises
	A-2	  	Floor Plan of Second Floor Premises
	A-3	  	Floor Plan of Third Floor Premises
	A-4	  	Landlord’s Additional Property
	B	  	Tenant’s Equipment
	C	  	Chemicals and Hazardous Materials
	D	  	Rules and Regulations

  
 ii 

 This Lease (this “Lease”) is made and entered into as of the day of ____
December, 2017, by and between SCIENCE PARK DEVELOPMENT CORPORATION, a Connecticut corporation having a principal place of business at 5 Science Park, New Haven, Connecticut 06511 (herein referred to as “Landlord”) and ARVINAS,
INC., a Delaware corporation having a principal place of business at 5 Science Park, New Haven, Connecticut 06511 (herein referred to as “Tenant”). 

WITNESSETH: 
 Landlord warrants
and represents to Tenant that it is a corporation organized and in good standing under the laws of the State of Connecticut and that it has full right, power and authority to enter into this Lease in the manner hereinafter subscribed. Tenant
warrants and represents to Landlord that it is a corporation organized and in good standing under the laws of the State of Delaware and that it has full right, power and authority to enter into this Lease in the manner hereinafter subscribed. Based
upon the foregoing, Landlord hereby leases to Tenant, and Tenant hereby hires from Landlord, the Leased Premises as hereinafter defined, for the term, rentals, and upon other conditions and covenants as follows: 

ARTICLE 1. LEASED PREMISES 

1.1 Leased Premises. 
 (a)
Landlord is the owner of the real property located at Science Park, New Haven, Connecticut as described on Exhibit A attached hereto (the “Property”). The Tenant shall lease from Landlord the following premises located in
Science Park Building 5 (“Building 5”), which is located on the Property: (i) approximately 7,873 rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-1 (the “First Floor Premises”); (ii) approximately 10,249 rentable square feet on the second floor of Building 5, as shown on the floor plan attached hereto as Schedule A-2 (the “Second Floor Premises”); and approximately 9,456 rentable square feet on the third floor of Building 5, as shown on the floor plan attached hereto as Schedule A-3 (the “Third Floor Premises”). Tenant shall have exclusive use of the First Floor Premises, the Second Floor Premises, the Third Floor Premises and Landlord’s fixtures, equipment and
personalty set forth in Schedule A-1 attached hereto (“Landlord’s Additional Property”). The First Floor Premises, the Second Floor Premises, the Third Floor Premises and the
Landlord’s Additional Property shall be referred to herein collectively as the “Leased Premises.” Landlord’s Additional Property shall be considered part of the Leased Premises but shall remain property of the Landlord. 

(b) Tenant’s rights under this Lease shall include, in common with other tenants of Building 5 or buildings within which the Leased
Premises may be located from time to time, use of the land and the facilities, accesses, hallways, roadways, sidewalks, and like service and scenic improvements and grounds (with the exception of parking areas), which are intended for the common use
of tenants of Building 5 or such buildings (“Common Facilities”). 

  
 1 

 1.2 Parking. The rental of the Leased Premises will include the use of up to
seventy five (75) parking spaces (“Tenant’s Parking Spaces”), in parking lots in common with other tenants and in locations in reasonable proximity to Building 5 as designated by Landlord. 

ARTICLE 2. TERM 

2.1 Term; Commencement Date. The term of this Lease (the “Term”) shall commence on January 1, 2018
(the “Commencement Date”) and Landlord agrees to deliver to Tenant, and Tenant agrees to accept, exclusive possession of the Leased Premises as set forth in Section 2.4 below. Unless sooner cancelled or
terminated or extended in accordance with the terms of this Lease, the Term will expire with respect to the entire Leased Premises as of December 31, 2022 (the “Expiration Date”). 

2.2 Omitted. 
 2.3
Landlord’s Contribution. Landlord shall contribute rent abatements up to the total amount of ONE HUNDRED FIFTY THOUSAND DOLLARS ($150,000.00) (“Landlord’s Contribution”) on account of the cost
of refurbishing the Leased Premises including design and engineering costs. Landlord’s Contribution shall be available to Tenant only as follows: (i) Tenant shall submit to Landlord a written request to utilize a portion of Landlord’s
Contribution as an abatement of one or more monthly installments of Base Rent (as hereinafter defined) (each a “Contribution Request”); (ii) each Contribution Request shall include evidence reasonably satisfactory to Landlord
that Tenant has actually paid to contractors and other relevant professionals an amount at least equal to the amount sought in the Contribution Request in connection with construction, design and or other service and materials directly related to
and necessary in connection with the Expansion Project (“Refit Expenses”); (iii) unless a Contribution Request is disputed by Landlord within ten (10) days from receipt by Landlord, Tenant shall be entitled to abatement
of Base Rent monthly installment(s) first payable not less than thirty (30) days from submission of such Contribution Request to Landlord; (iv) in addition to the foregoing: (A) Tenant shall be limited to no more than three
(3) contribution requests per year; (B) each Contribution Request shall be in an amount not less than the lesser of the remaining unused portion of Landlord’s Contribution and the Base Rent payable for one (1) month and
shall specify how Tenant intends to apply the Base Rent abatements to upcoming monthly installment(s) of Base Rent; and (C) monthly abatements of Base Rent shall be applied to whole months and Tenant shall have no right to a partial abatement
of monthly Base Rent other than with respect to the last Contribution Request. 
 2.4 “As Is” Condition; No Representations by
Landlord. 
  

	 	A.	 Tenant acknowledges that it is currently in possession and control of the Second Floor Premises and the Third
Floor Premises pursuant to the terms of the Existing Lease (as hereinafter defined). Tenant hereby accepts Landlord’s tender of possession of the Second Floor Premises and Third Floor Premises in their “as is” condition as of the
Commencement Date. 

  
 2 

	 	B.	 As of the Commencement Date, Landlord shall tender Tenant possession of the First Floor Premises in its then
“as is” condition and Tenant agrees to accept possession of the Leased Premises in its “as is” condition as of the Commencement Date. 

  

	 	C.	 Except as provided in Section 2.5 below, Tenant relies on no warranties or representations, express or
implied, of Landlord or any agent or other party associated with Landlord as to its condition or repair, or as to taxes or any other matter relating to the Leased Premises, except as otherwise expressly provided in this Lease. 

 

	 	D.	 Subject to Section 2.3 above, Tenant shall be responsible for all costs associated with any modifications
or improvements to the Leased Premises, consistent with and subject to the provisions of Article 6 hereof. 

  

	 	E.	 Tenant acknowledges that Landlord owns but is permitting Tenant to make use of Landlord’s Additional
Property (consisting of certain furnishings, fixtures, equipment and other improvements as set forth on Schedule A-4 attached hereto). Landlord shall ensure that all Landlord’s Additional Property
is in good working order as of the Commencement Date but Landlord specifically disclaims any further responsibility therefor and Tenant agrees that Landlord shall not be responsible for repairs or maintenance of any of Landlord’s Additional
Property from and after the Commencement Date. Tenant acknowledges that: (i) Landlord owns and shall retain title to the Landlord’s Additional Property; (ii) Tenant may make use of the Landlord’s Additional Property during the
Term of this Lease; (iii) Landlord expressly disclaims any warranty of any sort express or implied under law with respect to the Landlord’s Additional Property including with respect to any use thereof that may be made by Tenant;
(iv) Tenant accepts the use of the Landlord’s Additional Property in its then “as-is” condition with “all faults” and shall defend and indemnify the Landlord with respect to any
claims arising from or related to the use of the Landlord’s Additional Property; and (v) upon the expiration or sooner termination of this Lease, Tenant shall return and/or turn over possession to Landlord of all Landlord’s Additional
Property in like condition as of the date of this Lease, reasonable wear and tear and casualty excepted. 

 2.5
Limited Warrantees by Landlord. Landlord warrants that: 
  

	 	A.	 the Leased Premises and Building 5 are in compliance with all applicable laws, regulations and codes, including
the Americans with Disabilities Act, all as in effect as of the date of this Lease; and 

  

	 	B.	 there are no friable asbestos or other Hazardous Materials (as hereinafter defined) in Building 5 other than
those Hazardous Materials that are currently being used or which may be used properly and in compliance with law in the operation of Building 5 or are being used by other tenants of Building 5 in the operation of their businesses and laboratory
facilities. 

  
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 2.6 Tenant’s Work. Tenant, at its sole cost, subject only to the provisions of
Section 2.3 above, shall be responsible for any construction and alterations within the Leased Premises together with the installation of its furniture, fixtures and business equipment, including telecommunications cabling and equipment,
security systems, and any other ancillary systems it may require as approved by the Landlord in writing, which approval shall not be unreasonably withheld or delayed (the “Tenant’s Work”), at its expense, and in a good
and workmanlike manner in accordance with all of its obligations under this Lease including, without limitation, Article 6 hereof. Tenant shall furnish and install any and all necessary trade fixtures, equipment and other items necessary for the
proper conduct of Tenants business subject to the reasonable approval of Landlord. All of the foregoing work and all work Tenant may undertake pursuant to Article 6 of this Lease shall be done in accordance with all laws, rules, regulations and
ordinances applicable thereto, including, if necessary, compliance with the Americans With Disabilities Act, as amended from time to time, and the acquisition by Tenant of a building permit from the municipal department having jurisdiction, if
required. Landlord agrees to cooperate with Tenant in obtaining required permits, including executing applications if required. In no event shall Landlord be required to provide or install any trade fixtures or equipment. Tenant shall comply and
cause all of its contractors to comply with the provisions of Article 6 of this Lease. 
 2.6.1 Tenant Grant
Applications. Landlord shall reasonably cooperate with Tenant’s efforts to secure funding from the Department of Economic and Community Development in connection with Tenant’s Work. 

2.7 Early Access to Leased Premises. Tenant shall continue to have and maintain possession and control of the Third Floor
Premises and the Second Floor Premises through the Commencement Date. Upon full execution of this Lease and provision to Landlord of certificates of insurance complying with the requirements of this Lease, Tenant shall be granted access to the First
Floor Premises for limited purposes of making preparations for the use of the First Floor Premises and performance of Tenant’s Work, provided, however, Tenant may not interfere with or disturb the existing tenant of a portion of the First Floor
Premises. Tenant agrees that all provisions of this Lease, other than those provisions requiring payment of Base Rent and Additional Rent shall apply and be in full force and effect upon the granting of access to the First Floor Premises. Landlord
represents and warrants that the existing tenant on the First Floor Premises will vacate the First Floor Premises no later than January 15, 2018. 

  
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 ARTICLE 3. BASE RENT AND ADDITIONAL RENT 

3.1 Base Rent. 
  

	 	A.	 As used herein, the term “Lease Year” shall mean the
12-month period commencing on the Commencement Date and each succeeding 12-month period. During the initial Term, Tenant shall pay to Landlord a base rent (“Base
Rent”) for each Lease Year as follows: 

  

													
	 Months of Term
	  	Base Rent Rate
(Annually per RSF)	 	  	Applicable
RSF	 	  	Monthly Base Rent	 
	 January, 2018
	  	$	21.00	 	  	 	19,705	 	  	$	34,483.75	 
	 February, 2018—May, 2018
	  	$	21.00	 	  	 	27,578	 	  	$	48,261.50	 
	 June, 2018—July, 2018
	  	$	21.00	 	  	 	19,705	 	  	$	34,483.75	 
	 August, 2018—December, 2022
	  	$	21.00	 	  	 	27,578	 	  	$	48,261.50	 

  

	 	B.	 All Base Rent and recurring monthly installments of all items of “Additional Rent” (as hereinafter
defined) shall be payable each month, in advance, by not later than the first day of each month by way of wire transfer, electronic funds transfer, or other approved form of “same day” available funds. All Base Rent and recurring
Additional Rent will be prorated for partial months during the Term. 

 3.2 Additional Rent. In addition to
Base Rent, Tenant shall pay to Landlord additional rent (“Additional Rent”) consisting of all other sums of money as shall become due and payable by Tenant as expressly set forth in this Lease, including without limitation,
amounts due and payable under this Article 3, for default in the payment of which Landlord shall have the same remedies as for a default in the payment of Base Rent. 
  

	 	A.	 Definitions. For the purposes of this Agreement, the following terms shall have the meanings indicated:

 “Base Operating Expense Year” shall mean the calendar year 2018. 

“Base Property Tax Year” shall mean the calendar year 2018. 

“Base Operating Expenses” shall mean the amount of Operating Expenses attributable to the Base Operating Expense Year. 

“Base Property Taxes” shall mean the amount of Property Taxes attributable to the Base Property Tax Year. 

“Operating Expenses” shall mean all costs and expenses paid or incurred by or on behalf of Landlord: (i) in providing
HVAC service to the Leased Premises; and (ii) with respect to the ownership, maintenance, policing, repair, replacement, restoration, management, insurance, security and/or operation of Building 5 and any parking areas serving Building 5 or any
part thereof, and are herein deemed to include, but not necessarily be limited to the following: 

  
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	 	(a)	 the cost of all personnel, including wages, salaries and other compensation and fringe benefits, social
security taxes, payroll taxes, unemployment taxes, and any other such taxes; 

  

	 	(b)	 management fees that shall in no event exceed the reasonable and customary management fees charged from time to
time for comparable buildings in the greater New Haven Market; 

  

	 	(c)	 the cost of all utilities, fuel charges and related costs and services attributable to any portion of Building
5, including, but not limited to, all such utilities used or consumed in connection with the heating, ventilating, air conditioning, and water heating within Building 5; 

 

	 	(d)	 all office and janitorial supplies and similar materials used in the operation of Building 5;

  

	 	(e)	 the cost of all services incurred in the operation of Building 5 (and all service agreements and maintenance
contracts for same), including, but not limited to, protection and security service, window cleaning, common area cleaning service, plant and landscaping service, including plantings and re-plantings,
elevator, HVAC maintenance and repair, ice and snow removal, and trash removal; 

  

	 	(f)	 insurance, including, but not limited to, fire (including, without limitation, endorsements for extended
coverage, vandalism and malicious mischief, and theft and mysterious disappearance), public liability, rental interruption, boiler, water damage, sprinkler leakage, workers’ compensation, health, accident and group insurance; and

  

	 	(g)	 the cost of all maintenance, repairs, replacements and restorations, whether performed pursuant to obligations
under leases, as a result of fire or other casualty or otherwise, including, but not limited to, all maintenance, repairs and replacements (structural or non-structural) to the roof, inundation, exterior and
interior walls, floors and covering of same, replacement of plate, and other window glass, repair and replacement of all heating and cooling units and systems, repair and replacement of any portion of the sprinkler system, restrooms and all plumbing
facilities, utility conduits, pumping stations and force mains, signs, elevators, sidewalks and steps, all Building 5 service equipment, lighting units and fixtures including bulbs and tubes, all other Building 5 fixtures and equipment, and all
other maintenance, repairs, replacements and restorations of Building 5, all exclusive of items which are the direct responsibility of any other tenant. 

Notwithstanding anything to the contrary contained herein, Operating Expenses shall in all cases exclude: 

 

	 	(1)	 Items which are the direct responsibility of any tenant or are caused by the intentional or negligent acts of
any such tenant, its agents or licensees and the costs of which are recovered from such tenant; 

  

	 	(2)	 Expenses of alterations to the Leased Premises or Building 5 for the accommodation of a specific tenant or
tenants, which expenses shall be borne by such tenants; 

  
 6 

	 	(3)	 All costs of leasing space in Building 5 including office expenditures, legal fees and broker’s
commissions; 

  

	 	(4)	 Costs actually covered by Landlord’s insurance or other manner of reimbursement to the extent that payment
is actually received by Landlord, but not excluding the amount of any deductible; 

  

	 	(5)	 Repairs or other work resulting from damage by fire, windstorm or other casualty to the extent covered by
insurance in force or required to be carried by Landlord hereunder, or by the exercise of eminent domain; 

  

	 	(6)	 Leasing commissions, attorney’s fees, costs and disbursements and other expenses incurred in connection
with negotiations or disputes with tenants, other occupants or prospective tenants or other occupants; 

  

	 	(7)	 Landlord’s cost of utilities and other services that are sold to tenants and for which Landlord is
entitled to be reimbursed by tenants as an additional charge or rental payable under the lease with such tenant; 

  

	 	(8)	 Depreciation and amortization of any kind, except as otherwise provided herein; 

 

	 	(9)	 Interest on debt or amortization payments on any mortgage or mortgages and/or rentals under any ground lease or
other underlying leases; 

  

	 	(10)	 costs incurred in connection with the sale, financing or refinancing of Building 5; 

 

	 	(11)	 fines, interest and penalties incurred due to the late payment of Taxes or Operating Expenses;

  

	 	(12)	 organizational expenses associated with the creation and operation of the entity which constitutes Landlord;

  

	 	(13)	 sums paid to subsidiaries or other affiliates of Landlord for services on or to the Property, Building 5 and/or
Leased Premises, but only to the extent that the costs of such services exceed the competitive cost for such services rendered by persons or entities of similar skill, competence and experience; 

 

	 	(14)	 wages, salaries, fees, and fringe benefits paid to executive personnel or officers or partners or other
corporate personnel of Landlord; 

  

	 	(15)	 the cost or expense of any services or benefits provided generally to other tenants in Building 5 and not
provided or available to Tenant; 

  

	 	(16)	 expenses for the replacement of any item covered under warranty, unless Landlord has not received payment under
such warranty; 

  

	 	(17)	 any cost or expense related to removal, cleaning, abatement or remediation of “hazardous materials”
in or about Building 5, common area or Property, including, without limitation, hazardous substances in the ground water or soil; 

  

	 	(18)	 all costs of purchasing or leasing sculptures, paintings or other works or objects of art;

  

	 	(19)	 all bad debt loss, rent loss, or reserves for bad debt or rent loss, 

 

	 	(20)	 property Taxes and amounts excluded from the definition thereof; 

 

	 	(21)	 the cost of any improvements to Building 5 or related improvements that are required to be capitalized by
generally accepted accounting principles (except that Landlord may include the amount each year that amortizes such improvements in equal annual installments over their useful life as determined by generally accepted accounting principles);

  

	 	(22)	 rent paid or payable under ground leases (other than in the nature of additional rent consisting of Property
Taxes or Operating Expenses); 

  
 7 

 (23) advertising, entertainment and promotional costs that are paid or incurred for Building 5;
and 
  

	 	(24)	 the portion of costs that Landlord incurs for the benefit of a building other than Building 5 (to the extent
that Landlord incurs costs that benefit Building 5 and another building). 

 “Property Taxes” shall mean
all real property taxes and assessments, water and sewer taxes and assessments, and any and all other governmental levies, taxes or charges, general or special, ordinary or extraordinary, unforeseen as well as foreseen, of any kind of nature
whatsoever, which may be assessed or imposed from time to time during any part of the Term by the City of New Haven and/or any other governmental taxing authority, upon the Property, Building 5 and/or the parking lot(s) from time to time serving
Building 5; provided, however, that Property Taxes shall not include any transfer, excise, income or corporate franchise tax levied on Landlord. If, due to a future change in the method of taxation or in the taxing authority, a tax or governmental
imposition, however designated (including, without limitation, any tax measured or payable with respect to income, profits, rents or other charges received by Landlord and levied against Landlord, the Property and/or Building 5) shall be levied
against Landlord, the Property and/or Building 5 in substitution, in whole or in part, or as an addition to or in lieu of any Property Taxes, then such tax or governmental imposition shall be deemed to be included within the definition of the term
“Property Taxes” for the purposes hereof. 
 “Tenant’s Proportionate Share” shall mean that fraction, the
numerator of which is the number of rentable square feet of floor space in the Leased Premises as set forth in Article 1 of this Lease, and the denominator of which (the “Denominator”) is the average of the total rentable
square feet of floor space in Building 5 actually under lease to tenants during the calendar year in question (as such number is determined by leases, whether verbal or in writing, and pursuant to the terms of which leases rent has commenced to be
payable), (said average being referred to as the “Average Occupancy Figure”). Notwithstanding the foregoing, in the event that the Average Occupancy Figure is less than ninety five percent (95%) of the total rentable square
footage in Building 5 during the Base Operating Expense Year or any other calendar year, then in such event (i) the Denominator described hereinabove shall be then established during such period in question at ninety five percent (95%) of the
total rentable square footage in Building 5, and (ii) those components of Operating Expenses which relate to and are incurred as a consequence of Building 5 tenant use and occupancy (including Building 5 maintenance and repair, janitorial and
cleaning expenses. Building 5 management fees and costs and Building 5 tenant electric expenses) shall be increased on a pro rata basis from the actual levels at which they are incurred during any given calendar year in question to the levels at
which they would have been incurred had the Average Occupancy Figure been ninety five percent (95%) of the total square footage in Building 5 during the calendar year in question. 

B. Expense and Tax Increases. In addition to the Base Rent, Tenant shall pay to Landlord, as Additional Rent, as
hereinafter provided, Tenant’s Proportionate Share of (i) increases in Operating Expenses over the Base Operating Expenses, and (ii) increases in Property Taxes over the Base Property Taxes (collectively referred to as the
“Expense and Tax Increases”). Prior to the end of the Base Operating Expense Year, and in advance of each calendar year thereafter during the Term, Landlord shall furnish Tenant with an estimate (which estimate may be changed
by Landlord from time to time) of Tenant’s Proportionate Share of the 

  
 8 

 
Expense and Tax Increases for the ensuing calendar year (or portion thereof). Commencing with the monthly installment of Base Rent payable for January, 2019, and thereafter on the first (1st) day
of each month during the Term, Tenant shall pay to Landlord one-twelfth (1/12th) of the amount of Landlord’s then current estimate of Expense and Tax Increases. Within 180 days after the end of each
calendar year following the Base Operating Expense Year and within 180 days after the end of the Term, Landlord shall submit to Tenant a statement, prepared by Landlord, of the actual Expense and Tax Increases for the preceding calendar year (or
partial calendar year in the event the Term shall end on a date other than a December 31st), and the figures used for computing Tenant’s Proportionate Share for the preceding calendar year,
and if Tenant’s Proportionate Share of Expense and Tax Increases so stated for such period is (i) more than the amount paid for such period, Tenant shall pay to Landlord the deficiency within thirty (30) days after submission of such
statement, or (ii) less than the amount paid for such period, at Landlord’s sole election, Tenant shall be entitled to a credit in the amount of such excess against amounts next coming due under this Paragraph or Landlord shall refund the
amount of such overpayment to Tenant (or a refund of such excess in the case of the end of the term of this Lease). Any such adjustment shall survive the expiration or earlier termination of the Term. If Landlord shall furnish such estimate
subsequent to the commencement of any such calendar year, then, until the first (1st) day of the month following the month in which such estimate is furnished to Tenant, Tenant shall pay to Landlord on the first (1st) day of each month an amount
equal to Tenant’s monthly payment with respect to Tenant’s Proportionate Share of Expense and Tax Increases for the last month of the preceding calendar year. 

3.3 Omitted. 
 3.4
Electricity. Tenant shall pay to Landlord, as Additional Rent hereunder, an amount equal to $1.62 per year for each rentable square foot of the Leased Premises, which shall be payable in equal monthly installments together with the regular
monthly payments of Base Rent and Additional Rent. 
 3.5 Absolute Obligation to Pay; No
Set-Off. Tenant’s obligation to make full and prompt payments of all Base Rent and Additional Rent when owed under the terms of this Lease is absolute. Base Rent and Additional Rent shall be paid
without set-off, withdrawal or deduction of any nature. 
 3.6 Partial Payments. Any
payment of Base Rent and/or Additional Rent which is less than the amount then due and owing to Landlord will be considered a payment against the oldest outstanding rental obligation and Landlord may accept such payment without affecting its rights
to collect the balance owed. 
 3.7 Interest on Late Payments of Base Rent, Additional Rent or Other Amounts Due. Any Base
Rent, Additional Rent or other amount which is owed by Tenant under this Lease and which is not paid within fifteen (15) days of the date when due shall carry interest at an annual rate (the “Default Rate”) equal to the
lesser of (i) the highest rate allowed by law from the date which is fifteen (15) days after the date such Base Rent and/or Additional Rent or other amount was due until the date of payment, and (ii) eighteen percent (18%) per
annum. 

  
 9 

 3.8 Bookkeeping and Audits. Landlord shall maintain books and records respecting
gas, electricity, Operating Expenses and Property Taxes and determine the same in accordance with sound accounting and management practices, consistently applied. Tenant or its representative shall have the right to examine those books and records
of Landlord and any managing agent reasonably necessary for purposes of auditing expenditures for gas, electricity, Operating Expenses and Taxes in question. Such examination shall take place during normal business hours at the place or places where
such records are normally kept. Each Annual Operating Expense Statement rendered to Tenant shall be considered final, unless Tenant has given written notice to Landlord of its intention to audit the books and records of Landlord, which notice must
be given within forty five (45) days following Tenant’s receipt of such Annual Operating Expense Statement. In the event that Landlord and Tenant are unable to resolve the dispute within forty five (45) days following Landlord’s
granting Tenant access to such books and records of the Landlord, then such dispute shall be submitted to an independent certified public accounting firm selected by Landlord, subject to Tenant’s reasonable approval of such firm, which approval
shall not be unreasonably withheld or delayed. The certification by such independent certified public accounting firm as to the proper amount shall be final and conclusive as between Landlord and Tenant. Tenant shall promptly pay the fees and costs
of such independent certified public accounting firm unless such certification determines that Tenant was overbilled by more than two (2%) percent in which case Tenant’s audit expenses will be paid by Landlord. Pending resolution of any such
exceptions in the foregoing manner, Tenant shall continue paying, without prejudice to Tenant’s position, Tenant’s Pro Rata Share of gas, electricity, Operating Expenses and Taxes paid or incurred during the applicable period in the
amounts determined by Landlord, subject to adjustment after any such exceptions are resolved. 
 3.9 Survival. The rights,
obligations and liabilities of Landlord and Tenant under this Article 3 shall survive the expiration or earlier termination of this Lease for any reason. 

ARTICLE 4. TAXES 

4.1 Personal Property Taxes. Tenant shall be solely responsible for and pay within the time provided by law all taxes and
assessments imposed on its inventory, furniture, trade fixtures, apparatus, equipment and any other of Tenant’s personal or other property. 

4.2 Property Taxes. Tenant’s liability for the payment of Property Taxes is governed by Section 3.2 of this Lease. 

4.3 Available Abatements of Real Property Taxes. Landlord shall use reasonable commercial efforts to assist Tenant’s efforts
to obtain the benefit of any “Enterprise Zone” abatements of Property Taxes that may be available as a result of, relating to, or in connection with the Tenant’s occupancy of the Leased Premises or Tenant’s business operations
therein (“Property Tax Abatements”). Landlord shall not be required to commence any adversarial proceeding, whether administrative or judicial, to obtain any ruling, file any appeal, or otherwise to defend any application and
shall not be accountable to the Tenant for any of its efforts in seeking Property Tax Abatements. In the event that any Property Tax Abatements are secured, Landlord shall credit the amount of the Property Tax Abatements, net of all out-of-pocket costs, expenses and fees incurred by Landlord in securing such Property Tax Abatements, in equal installments to the Additional Rent payable by Tenant during the
next six months after such Property Tax Abatements are received by or credited to Landlord by such taxing authority. Landlord makes no representations as to the availability of Property Tax Abatements and/or the Landlord’s rights with respect
thereto. 

  
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 4.4 Other Taxes and License Fees. Tenant shall pay before delinquency all license
and permit fees and taxes that may be imposed upon the business of Tenant on the Leased Premises. 
 4.5 Survival. The rights,
obligations and liabilities of Landlord and Tenant under this Article 4 shall survive the expiration or earlier termination of this Lease for any reason. 

ARTICLE 5. TENANT’S USE OF LEASED PREMISES 

The Leased Premises will be used by Tenant only for research, office and laboratory purposes and for purposes incidental thereto and for any
other uses consistent with the applicable zoning laws for City of New Haven and not otherwise prohibited by this Lease. Notwithstanding the foregoing, the Tenant shall, in all circumstances, use the Leased Premises for lawful purposes only and shall
not use or occupy, nor permit the use nor occupancy of, the Leased Premises or any portion thereof for any of the following purposes: retail sales to the general public; the development, production or sale of pornographic materials; operation or
promotion of a gambling establishment; or any use which creates fire, explosive or other similar hazard outside of normal research and laboratory use. Tenant shall at all times and in all respects comply with all local, state and federal laws,
ordinances, regulations and orders relating to land use, industrial hygiene, environmental (including, but not limited to the Environmental Laws as defined in Section 8.5) or similar laws, including the use, analysis, generation, manufacture,
storage, disposal or transportation of Hazardous Materials as defined in Section 8.4. 
 ARTICLE 6. ALTERATIONS 

6.1 Reconfiguration; Alterations or Improvements to Leased Premises. Subject to the approval of the Landlord, which approval may
not be unreasonably withheld, Tenant may reconfigure the Leased Premises at any time during the Term. Tenant shall not otherwise make any alterations, additions or improvements in or to the Leased Premises except with Landlord’s prior written
consent, which consent will not be unreasonably withheld. Without limiting the generality of the foregoing, it shall not be unreasonable for Landlord to withhold its approval or consent or require modifications to any proposed reconfiguration,
alterations, additions or improvements if there will be any effect upon or interference with the design or installation of any mechanical, electrical or other systems which interconnect to or could affect or be affected by mechanical, electrical,
HVAC or other Building 5 systems. 

  
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 6.2 Improvements to Become Property of Landlord. AH additions and other
improvements installed in the Leased Premises at any time except for Tenant’s trade fixtures and equipment, as set forth on Schedule B, or as otherwise set forth in one or more written notices to Landlord, either by Tenant or by Landlord
on Tenant’s behalf, shall become the property of Landlord and shall be surrendered with the Leased Premises upon termination of this Lease. Upon the termination of this Lease, Landlord may require the removal of any additions and improvements
installed in the Leased Premises that the Tenant installed without providing advance notice thereof to Landlord. If Tenant provides advance written notice to Landlord as to the installation of any additions or improvements to the Leased Premises,
Tenant may include in such notice a specific reference to this section of this Lease and request the Landlord to determine whether such additions or improvements must be removed by Tenant upon the termination of the Lease. Landlord shall respond to
such a notice from Tenant in writing within twenty (20) days of receipt, and state whether or the extent to which such additions and improvements must be removed upon the termination of the Lease and such written response from Landlord shall be
binding on the parties. Landlord acknowledges that Tenant has supplied certain equipment, as contained in Schedule B attached, and Tenant shall remove said equipment upon termination of this Lease. 

6.3 Tenant’s Removal of Trade Fixtures. Nothing in this Article shall prevent Tenant’s removal of its trade fixtures
upon the Expiration Date or earlier termination of this Lease in accordance with the terms hereof, but upon such removal, Tenant shall promptly, and at its own expense, repair and restore any damage caused by such removal. 

6.4 Tenant’s Compliance with Conditions of Construction. Tenant shall, before making any alterations, additions or
improvements permitted hereunder, obtain all permits, approvals and certifications required by any governmental or quasi-governmental body or authority, and (upon completion) certificates of final approval and/or completion thereof, and shall
deliver promptly copies of all such permits, approvals and certificates to Landlord. In performing any additions, alterations or improvements to the Leased Premises permitted hereunder, Tenant shall comply with all applicable laws, regulations and
ordinances. Tenant agrees to carry, and will cause its contractors and subcontractors to carry, worker’s compensation insurance in the amount required by law and general liability insurance with a limit of not less than One Million Dollars
($1,000,000.00) combined single limit per occurrence for bodily injury, personal injury and property damage liability. Each such policy shall name Landlord and, at Landlord’s request, Landlord’s Lenders (as such term is defined in
Section 10.1 hereof), as additional named insured(s) and Tenant shall furnish to Landlord prior to the commencement of construction appropriate certificates evidencing that such insurance is in effect. Any such alterations, additions or
improvements shall be at the sole expense of Tenant using contractors selected by Tenant and approved by Landlord, which approval shall not be unreasonably denied or delayed. Tenant shall notify Landlord in writing of the identity of each contractor
with whom it intends to contract at least five (5) business days prior to entering into a contract with such contractor. If Landlord has not notified Tenant in writing that Landlord disapproves of such contractor within five (5) business
days after Landlord was notified of the identity of Tenant’s proposed contractor, then such contractor shall be deemed approved. 

6.5 Mechanic’s Lien. If any mechanic’s lien is filed against the Property, Building 5 or the Leased Premises for work
claimed to have been done or materials claimed to have been furnished to or for the benefit of Tenant, whether related to work done pursuant to any provision of this Lease or otherwise, the lien, within forty five (45) days of its receipt of
notice of such filing, shall be discharged by Tenant at Tenant’s expense by filing a bond as required by law or by other reasonable means. 

  
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 ARTICLE 7. REPAIRS 

7.1 Landlord Maintenance. Landlord shall maintain and repair the public portions of Building 5 and Common Facilities, exterior
and interior, and shall make all structural repairs to Building 5, and repairs to the plate glass and roof and exterior walls subject to Tenant’s obligations under Sections 7.2—7.7 of this Lease. Landlord shall maintain in good operating
order and condition, the equipment serving Building 5 generally and the utility systems serving Building 5 and up to the Leased Premises but not utility fixtures within the Leased Premises and exclusively serving the Leased Premises. Landlord shall
have no obligation to maintain or repair any of fixtures, furniture, equipment or other personal property: (A) which are the property of the Tenant; (B) which were installed by the Tenant; (C) which are located in the laboratory area
of the Leased Premises, including, without limitation, fume hoods (including any fume hoods installed by Landlord), autoclaves, and glass wash units; or (D) which are Landlord’s Additional Property 

7.2 Tenant Maintenance. Subject to Section 7.1, Tenant shall take good care of and maintain the Leased Premises, shall not
waste the Leased Premises, Tenant shall also be responsible for its own janitorial services within the Leased Premises. Any contractors retained by Tenant for these purposes must be approved by Landlord in accordance with the provisions of
Section 6.4. 
 7.3 Tenant’s Liability for Damages. Notwithstanding any provision of Section 7.1 above, subject
to the provision of Section 25.3, Tenant shall be liable for all damage or injury to the Leased Premises or to any other part of the Property or Building 5 or to any other portion of the property known as “Science Park”, of which the
Property is a part, whether requiring structural or non-structural repairs, caused by or resulting from any intentional or unintentional act, negligence or willful conduct on the part of Tenant, a subtenant of
Tenant, their respective servants, employees, agents, contractors, subcontractors, licensees or invitees. All such damage or injury shall be repaired promptly by Tenant at its sole cost and expense to the satisfaction of Landlord. 

7.4 Tenant to Repair Damage. Tenant shall repair all damage to the Property, Building 5 and to the Leased Premises caused by the
moving, installing or removing of Tenant’s fixtures, furniture, equipment or other personal property. 
 7.5 Landlord May Make
Repairs at Tenant’s Expense. If Tenant fails after thirty (30) days’ notice to proceed with due diligence to make any repairs required to be made by it (unless in Landlord’s judgment, reasonably exercised, a delay of thirty
days may expose persons or property to possible damage or injury, wherein Landlord may proceed without notice to repair), repairs may be made by Landlord for the account of and at the expense of Tenant. The reasonable costs and expenses so incurred
by Landlord in making any such repairs shall be payable by Tenant as Additional Rent within thirty (30) business days following submission of reasonably detailed invoices therefor. 

  
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 7.6 Tenant to Notify Landlord of Defective Conditions. Tenant shall give Landlord
prompt written notice of any defective condition in the Leased Premises of which Tenant is aware, including but not limited to, any defective condition in the plumbing, heating system or electrical lines located in, servicing or passing through the
Leased Premises. 
 7.7 Quality of Work. Any and all work required or permitted to be done to or upon the Leased Premises by
way of repairs, alterations, additions or improvements by Landlord or Tenant, or the agents or employees of either, shall be of a quality equal to the original construction and shall be done in accordance with all applicable laws, regulations and
ordinances. 
 ARTICLE 8. COMPLIANCE WITH LAWS; INCREASED INSURANCE RATES; ENVIRONMENTAL LAWS 

8.1 Tenant to Comply with Laws and Regulations. Tenant, at its sole cost and expense, shall comply with all present and future
statutes, laws, orders, ordinances, rules, regulations and requirements of all federal, state, municipal and local governments, departments, commissions and boards, the directions of any public officer, and all orders, rules and regulations
including, without limitation, the Connecticut State Fire Prevention Code and the Connecticut State Fire Safety Code, relating or pertaining to the conduct of Tenant’s business or its specific use and occupancy of the Leased Premises (and not
to those laws, etc. which pertain to tenants generally, which shall be Landlord’s responsibility) (collectively, “Laws”). Landlord and not Tenant will make structural alterations if required by law, unless caused by
Tenant’s alterations or specific manner of use. 
 8.2 No Violation of Insurance Policies. Tenant shall not do or permit
any act to be done in or to the Leased Premises which will invalidate or be in conflict with any policies of insurance at any time carried by or for the benefit of Landlord with respect to the Leased Premises, Building 5 or Property. Tenant shall
not use the Leased Premises in a manner that will increase the rate of any insurance applicable to the Leased Premises, Building 5 or Property in effect on the Commencement Date. Landlord represents that as of the Commencement Date, the use of the
Leased Premises for office and laboratory purposes does not conflict with or invalidate any insurance nor subject Landlord to an increase in the rate of insurance. 

8.3 Tenant to Pay Costs, Fines and Penalties. Upon receipt of notice from Landlord, Tenant shall promptly pay all claims, costs,
expenses, fines, interest, penalties or damages that may be imposed upon or incurred by Landlord by reason of any Event of Default, provided that Tenant shall not be liable for any late charges or other costs that result from a delay by Landlord in
paying the same. Subject to the terms of Section 8.2, if Landlord’s insurance rates are increased during the Term of this Lease because of a special risk associated with Tenant’s use or occupancy, Tenant shall promptly reimburse
Landlord for said increase as Additional Rent, upon receipt of reasonably detailed evidence thereof. 

  
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 8.4 Hazardous Materials. As used herein, the term “Hazardous
Materials” shall mean and include those elements, materials, compounds, mixtures, wastes or substances (collectively “Substances”) which are designated as pollutant, toxic, infectious, flammable, radioactive
or hazardous (or contained in any list which is adopted) by the United States Environmental Protection Agency (the “EPA”), the State of Connecticut or any political subdivision thereof, including without limitation the
Connecticut Department of Energy and Environmental Protection (“DEEP”), or is so designated under any of the Environmental Laws, and, whether or not included in any such list or designated as such, shall be deemed to include all
Substances containing petroleum, petroleum products and derivatives, chlorinated hydrocarbons, asbestos, and polychlorinated biphenyls (PCB’s). 

8.5 Environmental Laws. As used herein, the term “Environmental Laws” shall mean and include any Federal,
State, or local statute, law, ordinance, code, rule, regulation, order, or decree regulating or relating to the protection of human health or the environment, or regulating or imposing liability or standards of conduct concerning the use, storage,
discharge, handling, treatment, removal, disposal or transportation of any Hazardous Materials, as now or at any time hereafter in effect including, without limitation, Title 22a (“Environmental Protection”) of the
Connecticut General Statutes, including, but not limited to, Sections 22a—448 through 22a-457 of the Connecticut General Statutes (the “Superlien Statute”), the Federal
Comprehensive Environmental Response, Compensation and Liability Act, as amended, 42 U.S.C. §§9601 et. seq. The Superfund Amendments and Reauthorization Act, 42 U.S.C. §§9601 et. seq., the Federal Oil Pollution Act
of 1990, §§2701, et. seq., the Federal Toxic Substances Control Act, 15 U.S.C. §§ 2601 et. seq., the Federal Resource Conservation and Recovery Act as amended, 42 U.S.C. §§6901 et. seq., the Federal
Hazardous Materials Transportation Act, 49 U.S.C. §§1801 et. seq., the Federal Clean Air Act 42 U.S.C. §7401 et. seq., the Federal Water Pollution Control Act, 33 U.S.C. §1251 et. seq., the Rivers and Harbors
Act of 1899, 33 U.S.C. §§401 et. seq., Title X of Pub.L. 102.550 (Oct. 28, 1992), and all laws, statutes, rules, ordinances, and all rules and regulations of the EPA, the DEEP or any other state or federal department, board, or
agency, or any other agency or governmental board or entity having jurisdiction over the Property, as any of the foregoing have been, or are hereafter created, amended, supplemented, re-authorized, superseded
and replaced from time to time. 
 8.6 Chemicals and Hazardous Materials. Tenant shall, upon Landlord’s request, no more
often than quarterly, provide Landlord with a list of chemicals and Hazardous Materials Tenant intends to store or use in the Leased Premises. Such list, for the first Lease Year, is attached hereto as Schedule C. Tenant shall promptly notify
Landlord in writing whenever Tenant intends to store or use other chemicals or Hazardous Materials than appear on such list, provided, however, Tenant is permitted without prior notice and consent of landlord to use those Hazardous Materials
necessary for the conduct of its business provided they are not used in “reportable quantities” and they are used in accordance with Environmental Laws. 

8.7 Compliance with Environmental Laws. Tenant shall at its own expense procure, maintain in effect and comply with all
conditions of any and all permits, licenses and other government and regulatory approvals required for Tenant’s activities or use of the Leased Premises, including, without limitation, the use, transportation, storage and discharge of

  
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 Hazardous Materials. Tenant shall comply at all times with all Environmental Laws applicable to Tenant’s
activities or use of the Leased Premises. Except as so discharged in accordance with all applicable Environmental Laws, Tenant shall cause any and all Hazardous Materials removed from the Leased Premises to be removed and transported solely by duly
licensed haulers to duly licensed facilities for final disposal of such Hazardous Materials. Tenant shall in all respects handle, treat, deal with and manage any and all Hazardous Materials in, on, under or about the Leased Premises in total
conformity with all applicable Environmental Laws and prudent industry practices regarding management of such Hazardous Materials. Upon expiration or earlier termination of the Term of the Lease, Tenant shall: (i) cause all Hazardous Materials
used by Tenant to be removed from the Leased Premises by an appropriately licensed contractor and to be transported for use, storage or disposal in accordance and compliance with all applicable Environmental Laws; and (ii) shall arrange for a
licensed industrial hygienist or other appropriately licensed contractor to clean the Leased Premises and any remaining furniture, fixtures and equipment of any and all Hazardous Materials used by Tenant and to provide to Landlord appropriate and
customary written certifications specifying the completion of same including descriptions and/or serial numbers of all equipment cleaned by the contractor (“Cleaning Certificates”). Tenant shall promptly deliver to Landlord
copies of all Cleaning Certificates and hazardous waste manifests reflecting the legal and proper cleaning of the Leased Premises and remaining furnishings, fixtures and equipment and the legal and proper disposal of all Hazardous Materials removed
from the Leased Premises. 
 8.8 Tenant to Indemnify Landlord and Landlord’s Lenders. Tenant shall indemnify and hold
harmless Landlord, Landlord’s Lenders (as defined in Section 10.1), and their respective directors, officers, employees and agents (each an “Indemnified Party”) from and against any and all claims, actions,
proceedings, investigations, suits, penalties, fines, costs, expenses, sums paid in settlement, judgments, losses and damages, directly or indirectly arising as a result of or caused by Tenant’s failure to comply fully with any applicable Laws
or Environmental Laws or the terms of this Article 8, except as a result of the negligence or misconduct of an Indemnified Party. Landlord shall indemnify and hold harmless Tenant and its directors, officers, employees and agents from and against
any and all claims, actions, proceedings, investigations, suits, penalties, fines, costs, expenses, sums paid in settlement, judgments, losses and damages, directly or indirectly arising as a result of or caused by Landlord’s failure to comply
fully with any applicable Laws or Environmental Laws. The foregoing indemnification shall include without limitation all costs of environmental cleanup, all fees and expenses of environmental consultants and engineers hired by an indemnified party
and reasonable attorney’s fees incurred by an indemnified party directly or indirectly as a result of any claim for which indemnification is provided herein. Tenant shall be responsible for the cost of any and all repairs to the Property,
Building 5, the Leased Premises and any other real or personal property owned by Landlord or its subsidiaries from time to time, structural and nonstructural, required as a result of Tenant’s violation of any such Laws or Environmental Laws or
terms of this Article 8. The terms of this Article 8 shall survive the termination or expiration of this Lease for any reason. 

  
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 ARTICLE 9. FLOOR LOAD; MACHINERY AND EQUIPMENT 

9.1 Floor Load. Tenant shall not place a load upon any floor of the Leased Premises exceeding the established floor load of 100
pounds per square foot. All such equipment and material installation shall be placed and maintained by Tenant at its expense, with equipment in settings sufficient to absorb vibration and noise and prevent annoyance to other tenants in Building 5.

 9.2 Engines, Machinery and Equipment. Tenant shall provide Landlord with a list of all engines, machinery and similar equipment
Tenant intends to store or use in the Leased Premises, excluding ordinary office equipment. Such list is attached hereto as Schedule B. Tenant shall notify Landlord in writing in advance whenever Tenant intends to store or use engines, machinery or
similar equipment in the Leased Premises other than that listed on Schedule B. 
 ARTICLE 10. TENANT’S OBLIGATIONS TO
LANDLORD’S LENDERS 
 10.1 Subordination. The rights of Tenant under this Lease will always be subject and
subordinate to the rights, title and interest of all present and future lenders who may from time to time extend credit to Landlord which extensions of credit may be secured in whole or in part by a mortgage or other security interest on the
Property, Building 5 or Leased Premises (collectively, “Landlord’s Lenders”) and all renewals, modifications, replacements and extensions of any such mortgage or other security interest, provided Tenant’s occupancy
will not be disturbed. This provision is automatic without any further consent or confirmation by Tenant, but at Landlord’s request, Tenant will execute an agreement in form and content reasonably acceptable to Landlord and Landlord’s
Lenders (a “Subordination Nondisturbance Agreement”) confirming this provision. Tenant will sign a commercially reasonable Subordination Nondisturbance Agreement and return it to Landlord within thirty (30) days after
Landlord makes the request in writing. Landlord shall obtain from Landlord’s Lenders a reasonable form of Subordination Nondisturbance Agreement in recordable form to the effect that as long as Tenant shall keep, carry out, and perform all of
the terms, covenants and provisions contained in this Lease which are to be performed by Tenant, within all applicable notice and cure periods, Landlord’s Lenders, or their assignees, will not disturb Tenant’s occupancy of the Leased
Premises. 
 10.2 Estoppel Certificate. Tenant agrees to execute and deliver to Landlord within thirty (30) days of
Landlord’s written request a certificate or statement reasonably required to confirm that this Lease is in full force and effect, whether it has been modified, and if so, how, and whether, to Tenant’s knowledge, Landlord is in default in
the performance or observance of any covenants or conditions in this Lease on Landlord’s part to be performed or observed, or any condition exists that with the passage of time would, if uncorrected, constitute a default (an “Estoppel
Certificate”). Landlord shall deliver to Tenant a comparable Estoppel Certificate within thirty (30) days after written request from Tenant. 

  
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 10.3 Prohibition Against Recording Lease. Neither party shall record this Lease on
the New Haven Land Records. Any such recordation of this Lease shall be an Event of Default hereunder and such recordation shall be null and void and of no force and effect. 

ARTICLE 11. LIMITATIONS ON LANDLORD’S LIABILITY 

11.1 Property. Landlord shall not be liable for any loss of or damage to any property of Tenant, its employees, agents,
contractors, subcontractors, licensees or invitees, whether by theft or otherwise, unless caused by the negligence or willful misconduct of Landlord, its agents, employees or contractors. 

11.2 Landlord Not Liable for Other Tenants. Landlord and its agents shall not be liable for any injury or damage to persons or
property caused by other tenants or persons in, upon or about Building 5, Property or other real property in the vicinity of the Property, or caused by operations in construction of any private, public or quasi-public work in or to Building 5, the
Property or such other real property, unless caused by the negligence or willful misconduct of Landlord. 
 11.3 Limitation on
Landlord’s Liability. Landlord shall not be liable to Tenant and, to the fullest extent allowed by applicable law, Tenant, for itself and its employees, contractors, subcontractors, agents, licensees and invitees, hereby waives all claims
against and releases Landlord, Landlord’s Lenders, and their respective directors, officers, employees and agents from and against any and all claims, actions and causes of action which they or any of them may have now or in the future, for
damages resulting from any entry into the Leased Premises, loss of life, personal injury, loss of business, or damage to any property on or about the Property or the real property known as “Science Park” of which the Property is a part or
the approaches, entrances, streets, sidewalks or corridors thereto, by or from any cause whatsoever, including without limitation, damage caused by any defect in the Leased Premises or any other portion of Building 5 or the Property or the real
property known as “Science Park”, or by water leakage of any character from the roof, walls, basement or other portion of Building 5 or the Leased Premises or caused by gas, fire, oil, electricity or any cause whatsoever in, on or about
the Leased Premises or any other portion of Building 5 or the Property or the real property known as “Science Park”, provided the same does not arise, in whole or in part, by the negligence, willful misconduct or breach of contract of or
by Landlord, its agents, employees or contractors. 
 11.4 Limitation on Damages. OTHER THAN AS PROVIDED IN SECTION 31.1 OF
THIS LEASE, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER OR ANY OTHER PERSON OR ENTITY UNDER ANY CONTRACT, STRICT LIABILITY, NEGLIGENCE OR OTHER LEGAL OR EQUITABLE THEORY, FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, EXEMPLARY OR INDIRECT
DAMAGES OR LOST PROFITS, HOWEVER CAUSED, IN CONNECTION WITH THE SUBJECT MATTER OF THIS AGREEMENT, WHETHER OR NOT SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. 

  
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 ARTICLE 12. TENANT’S OBLIGATION TO PROTECT LANDLORD AND LANDLORD’S LENDERS 

12.1 Tenant to Protect and Reimburse Landlord. To the fullest extent allowed by applicable law, Tenant will defend, indemnify
and hold harmless Landlord, Landlord’s Lenders, and their respective directors, officers, employees and agents (individually, a “Landlord Indemnified Party”), from and against any and all claims, damages, liabilities,
penalties, fines, judgments, forfeitures, actions, causes of action, losses, costs and expenses, costs and expenses (including, without limitation, reasonable attorney’s fees incurred by any Landlord Indemnified Party in defending against any
claim for which indemnification is provided herein), which result from, or arise out of or in connection with any one or more of the following (including claims resulting from the death of or injury to any person or damage to any property
whatsoever, arising from or caused in whole or in part, directly or indirectly, by): 
 A. Any breach or violation by Tenant or a subtenant
of Tenant or their respective servants, employees, agents, contractors, subcontractors, licensees or invitees of any provision of this Lease; 

B. The negligence or willful act of Tenant or a subtenant of Tenant or their respective servants, employees, agents, contractors,
subcontractors, licensees or invitees; 
 C. The use and occupancy of the Leased Premises by Tenant or any other party during the Term of
this Lease; or 
 D. (i) the use, storage, transportation, disposal, release, discharge or generation of, Hazardous Materials to, in, on,
under, about or from the Leased Premises or the Property or the real property known as “Science Park” of which the Property forms a part, by Tenant, a subtenant of Tenant or their respective employees, contractors, subcontractors, agents,
licensees or invitees, or (ii) Tenant’s failure to comply with any Environmental Laws. Tenant’s obligation under this Section shall include, without limitation, and whether foreseeable or unforeseeable, any and all costs incurred in
connection with any investigation of site conditions, and any and all costs of any required or necessary repair, cleanup, monitoring, remedial action, detoxification or decontamination of the Property or other portions of the real property known as
“Science Park” of which the Property forms a part (including, without limitation, the soil and ground water on or under the Property or such real property known as “Science Park”) and the preparation and implementation of any
closure, remedial action or other required plans in connection therewith, provided the cause of the same is due solely to Tenant, its agents, employees or contractors. Tenant’s obligations under this Section shall survive the expiration or
earlier termination of the Term of the Lease. For purposes of the indemnity provisions hereof, any acts or omissions of Tenant or a subtenant of Tenant or by employees, agents, assignees, contractors, subcontractors, licensees and invitees of Tenant
or a subtenant of Tenant or others acting for or on behalf of Tenant or a subtenant of Tenant (whether or not they are negligent, intentional, willful or unlawful) shall be strictly attributable to Tenant. 

12.2 Tenant to Defend Claims. If any action or proceeding is brought against an Landlord Indemnified Party by reason of a claim
described in Section 12.1., Tenant, upon written notice from Landlord, will at Tenant’s sole cost and expense, defend the action or proceeding with legal counsel approved by Landlord in writing, which approval shall not be unreasonably
withheld. Landlord shall give Tenant written notice of any such claim as soon as reasonably practicable but in any event within fifteen (15) days of Landlord receiving written notice of such claim. 

  
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 12.3 Landlord to Protect and Reimburse Tenant. To the fullest extent allowed by
applicable law, Landlord will defend, indemnify and hold harmless Tenant and its directors, officers, employees and agents (individually, a “Tenant Indemnified Party”), from and against any and all claims, damages,
liabilities, penalties, fines, judgments, forfeitures, actions, causes of action, losses, costs and expenses, costs and expenses (including, without limitation, reasonable attorney’s fees incurred by any Tenant Indemnified Party in defending
against any claim for which indemnification is provided herein), which result from, or arise out of or in connection with any one or more of the following (including claims resulting from the death of or injury to any person or damage to any
property whatsoever, arising from or caused in whole or in part, directly or indirectly, by): 
 A. Any breach or violation by Landlord or
its servants, employees, agents, contractors, subcontractors, licensees of any provision of this Lease; or 
 B. The negligence or willful
act of Landlord or its servants, employees, agents, contractors, subcontractors, licensees. 
 ARTICLE 13. FIRE AND OTHER CASUALTY

 13.1 Notification to Landlord; Obligation to Pay Base Rent and Additional Rent. If the Leased Premises or Building 5,
or any part thereof, shall be destroyed or partially damaged by fire or other casualty, Tenant shall continue to pay Base Rent and Additional Rent during any period of repair except as otherwise expressly provided in this Article or until the Lease
is terminated in accordance with the terms of this Article. 
 13.2 When Lease May Be Terminated; Apportionment of Base Rent and
Additional Rent. If by reason of casualty: 
 A. Building 5 is destroyed, this Lease shall terminate automatically and Tenant shall
vacate the Leased Premises as of the date of the casualty; 
 B. The Leased Premises are rendered wholly or substantially untenantable and
restoration will require longer than 120 days, this Lease shall terminate at the option of Landlord made within 30 days of the casualty or loss causing such condition and Tenant shall vacate the Leased Premises as of the date of such casualty or
loss; or 
 C. Any portion of Building 5 is otherwise substantially damaged and Tenant’s access to or use of the Leased Premises is
materially and adversely affected, and restoration of such damage shall require longer than 120 days to complete, then Landlord may either elect to repair the damage or may cancel this Lease by giving written notice of cancellation to Tenant within
thirty (30) days after such casualty or loss. Upon the giving of such notice of cancellation, this Lease shall terminate, and Tenant shall vacate and surrender the Leased Premises to Landlord. If

  
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 Landlord shall have decided to repair any damage as aforesaid, the damage (except as to Tenant’s fixtures,
personal property or leasehold improvements made by Tenant) shall be repaired by and at the expense of Landlord within one hundred and eighty (180) days of the casualty and the Base Rent and/or Additional Rent shall be abated from the date of
casualty until such restoration is complete according to the part of the Leased Premises, if any, which is not usable by Tenant, but if the remaining usable portion does not enable Tenant to conduct its business in a reasonable manner, then
abatement shall be determined by the extent of material interference with Tenant’s business. Landlord must restore the Leased Premises and Common Areas if required. If Landlord shall not complete the restoration within said 180-day period, then, provided that the Leased Premises were materially damaged or Tenant’s access to or use of the Leased Premises is materially and adversely affected by the casualty, Tenant may elect to
terminate this Lease by written notice given to Landlord within thirty (30) days after the end of said 180-day period. If the casualty occurred during the last 180 days of the Term and the Leased Premises
was materially damaged, then Tenant may elect to terminate this Lease by written notice given to Landlord within thirty (30) days after the date of the casualty. 

13.3 Intentionally Omitted. 

13.4 Landlord Need Not Replace Tenant’s Property. Tenant acknowledges that Landlord is not required to repair or replace any
of Tenant’s property or Tenant’s improvements to the Leased Premises and that Landlord will not carry insurance on Tenant’s furnishings, fixtures, equipment, improvements or other personal property. 

13.5 Alternate Parking. In the event that Tenant parking as provided for in this Lease is temporarily unavailable because of
fire, other casualty or any other reason outside of Landlord’s control, Landlord shall endeavor in good faith to provide alternative parking within the Science Park complex. 

ARTICLE 14. TAKING BY GOVERNMENTAL AUTHORITY 

14.1 Termination of Lease; Waiver of Claim by Tenant. If Building 5 or any portion of Building 5 which includes the Leased
Premises shall be taken by condemnation (also known as “eminent domain”) by any authority having power so to do or is conveyed to such authority in lieu of condemnation, this Lease shall terminate from the date of title vesting in such
authority. If any portion of Building 5, which does not include the Leased Premises but materially and adversely affects Tenant’s access to or use of the Leased Premises, shall be so taken, each of Landlord and Tenant shall have the option, at
its sole discretion, to cancel this Lease by providing written notice to the other within sixty (60) days of the effective date of any such taking. All proceeds from the taking will belong to Landlord and Tenant waives any rights it might have
to such proceeds. Tenant, however, may proceed with any independent claim against the taking authority as to moving costs and improvements thereto. 

14.2 Taking Not Involving Building 5. If a portion of the Property shall be taken by condemnation as described in
Section 14.1. or conveyed in lieu of condemnation, which portion does not include any portion of Building 5 (or excepting an inconsequential portion of Building 5 not affecting the Leased Premises or access thereto), the Term of this Lease
shall not terminate but shall continue in full force and effect according to its terms. Tenant shall not be entitled to any award or damages from such taking. 

  
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 ARTICLE 15. TENANT’S RIGHT TO ENCUMBER, ASSIGN, OR SUBLEASE 

15.1 Tenant May Not Use Lease as Collateral. Tenant may not voluntarily or involuntarily use this Lease for collateral (known as
“encumbering” the Lease) without Landlord’s prior written consent, which consent will not be unreasonably withheld. 

15.2 Assignment or Subletting by Tenant. Except as permitted under Section 15.3.D of this Lease, Tenant may not assign or
transfer its interest in this Lease without Landlord’s prior written consent, which consent shall not be unreasonably withheld. Tenant may sublet any portion of the Leased Premises subject to the Landlord’s right to approve any subtenant,
which approval shall not be unreasonably withheld or delayed. Consent to an assignment, transfer or sublease shall not be interpreted as consent to any renewal, additional or subsequent assignment, transfer or sublease. 

15.3 Conditions Precedent to Assignment, Transfer or Sublease. An assignment, transfer or sublease shall become effective only
upon and subject to the following conditions: 
  

	 	A.	 Tenant shall have provided to Landlord such information relating to the proposed assignment, transfer or
sublease as Landlord may reasonably request, including but not limited to the identity of the proposed assignee, transferee or sublessee together with tax returns and financial statements for the proposed assignee, transferee or sublessee; and

  

	 	B.	 Tenant shall have provided Landlord with an executed copy of all written agreements relating to the assignment,
transfer or sublease, and such agreements are in a form reasonably acceptable to Landlord; and 

  

	 	C.	 The proposed assignee, transferee or subtenant shall execute and deliver to Landlord such agreements as
Landlord and Landlord’s Mortgagees may reasonably require in order to evidence the assumption of the obligations and liabilities under this Lease; and 

  

	 	D.	 Landlord shall have approved in writing such assignment, transfer or sublease, which approval shall not be
unreasonably denied; provided, however, that no such approval shall be required in the case of an assignment, transfer or sublease to a parent, affiliate or subsidiary of Tenant or in the case of a merger, consolidation, sale of stock or sale of
substantially all of the assets of the Tenant, provided that the conditions set forth in clauses A, B and C of this Section 15.3 are satisfied and in all instances Tenant shall continue to be subject to Section 15.4 of this Lease;
and 

  

	 	E.	 Landlord’s Lenders shall have approved any such proposed assignee of this Lease or any such proposed
subtenant or other occupant of the Leased Premises. 

  
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 15.4 Tenant Not Released. No assignment or transfer of Tenant’s interest
hereunder nor a sublease of the Leased Premises or any part thereof will release Tenant from its obligations under this Lease and Landlord may look to Tenant for continued performance. 

15.5 Landlord May Collect Charges. Landlord may collect use and occupancy charges from a subtenant of Tenant without being
considered to have consented to the sublease. 
 15.6 Surplus Rentals from Assignment or Subleasing. To the extent that Tenant
receives consideration in connection with an assignment of this Lease or to the extent that the Tenant receives a subrental amount for all or such applicable portion of the Leased Premises in excess of the sum of (or pro rated portion of) the Base
Rent and Additional Rent payable under this Lease (collectively, “Consideration or Surplus Rentals”), Landlord shall be entitled to 50% of such Consideration or Surplus Rentals after the Tenant has first been fully reimbursed from such
Consideration or Surplus Rentals for any expenses incurred in connection with securing such assignee, subtenant or occupant, including, but not limited to brokerage fees, free rent or tenant improvement allowance. 

15.7 Shared Use By Other Entities. Except as permitted under Article 15, no use of the Leased Premises by any person or entity
other than Tenant is permitted without the prior express written consent of Landlord, which consent may be conditioned on the following, among other reasonable conditions established by Landlord: (1) Landlord’s receipt of prior written
request therefor and proof of insurance coverage to Landlord’s satisfaction, and (2) provision to Landlord’s satisfaction for payment by Tenant of any additional costs and charges occasioned by such use. 

ARTICLE 16. ACCESS TO LEASED PREMISES 

16.1 Landlord to Have Access in Emergency. Landlord and Landlord’s agents shall have the right to enter the Leased Premises
at any time if Landlord or Landlord’s agent reasonably believes an emergency exists. 
 16.2 Landlord’s Right to Enter.
Except as provided in Section 16.1., Landlord and Landlord’s agents shall have the right to enter the Leased Premises upon reasonable advance notice to Tenant and during business hours or at such other times as agreed, for the
following purposes: 
 A. Inspecting the Leased Premises; 

B. At any time during the Term, showing the Leased Premises to prospective purchasers and lenders; 

C. During the final six months of the Term, showing the Leased Premises to prospective tenants; and 

  
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 D. To make repairs: (i) as Landlord may deem necessary to the Leased Premises; or
(ii) repairs or alterations to any other portion of Building 5 or which Landlord may elect to perform following Tenant’s failure to make repairs or perform any work which Tenant is obligated to perform under this Lease after notice and
applicable cure periods; or (iii) for the purpose of complying with laws, regulations and other directives of governmental authorities. In exercising its rights under this Section 16.2, Landlord shall not unreasonably interfere with
Tenant’s use of the Leased Premises. If solely as a result of Landlord making repairs under subparagraph (i) hereof, the Tenant’s use of the Leased Premises is materially interrupted for more than five (5) continuous days, then
all Base Rent and Additional Rent shall thereafter abate until the Tenant’s use of the Leased premises is materially restored. 

16.3 Landlord May Make Changes to Building 5. Landlord shall have the right at any time, to make any changes, deletions and
additions to Building 5 and to the entrances, exits, stairs, halls, elevators and common spaces as Landlord believes necessary or desirable, provided that such changes shall not materially adversely affect Tenant’s access to or use of the
Leased Premises or reduce the square footage thereof. 
 16.4 Safety Inspections. No more frequently than once every three
months, Landlord at its expense shall have the right to have a safety inspection performed by an appropriately licensed third party laboratory inspector (a “Safety Inspection”). All such Safety Inspections shall be limited to
the operation of and materials, chemicals and processes employed by Tenant in the portions of the Leased Premises used for laboratory purposes. Landlord shall give the Tenant at least five (5) business days advance notice of any such Safety
Inspection and all Safety Inspections shall be conducted in such a manner and at such a time as to minimize any disruption of business conducted by the Tenant. Tenant shall have the right to have a representative present during all Safety
Inspections and shall simultaneously be sent a copy of any written report or summaries with respect to each Safety Inspection. To the extent that safety issues and/or violations of any applicable law on the part of Tenant are identified, Tenant
shall remedy any such issues or violations in advance of a mutually agreed upon follow up Safety Inspection but in no event more than 30 days thereafter. Landlord may issue a default notice under Section 17.1.H of this Lease should Tenant fail
to remedy any such safety issues or violations of law as of the time of such follow up Safety Inspection. 
 ARTICLE 17. DEFAULT AND
TERMINATION 
 17.1 Events of Default. The occurrence of any one or more of the following events shall constitute an event
of default by Tenant hereunder (“Event of Default”): 
 A. Failure to pay any Base Rent, Additional Rent or any other rent
or monetary obligation under this Lease within five (5) days after Landlord provides to Tenant written notice of such payment being past due under the terms of this Lease (a “Rent Default Notice”), provided, however, that, in the
event that Landlord properly issues two Rent Default Notices, the Landlord shall thereafter not be obligated to provide any further Rent Default Notices and it shall be an Event of Default should Tenant fail to make any payment of Base Rent,
Additional Rent or any other rent or monetary obligation under this Lease more than five (5) days after being due under the terms of this Lease; 

  
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 B. Voluntary recourse to any protection or procedure under the United States Bankruptcy Code, as
amended, or any similar law. 
 C. There is filed against Tenant in any court pursuant to any statute, either of the United State of America
or of any state, a petition in bankruptcy or insolvency, or for reorganization, the appointment of a receiver or trustee of all or a portion of Tenant’s property, or for other relief of debtors, and within ninety (90) days thereof Tenant
fails to secure a dismissal thereof. 
 D. Failure to execute and deliver in a timely manner a Subordination Agreement, Estoppel Certificate
or other certificate in each case on reasonable forms acceptable to Tenant regarding the status of this Lease which continues for more than ten (10) days after written notice of such failure. 

E. Transfer of this Lease to another party by operation of law or otherwise in violation of the terms of this Lease. 

F. Abandonment of the Leased Premises. 

G. The recordation of this Lease on the New Haven Land Records in violation of Section 10.3 hereof. 

H. Failure to perform or comply with any other non-monetary obligation under this Lease within thirty
(30) days of written notice of such failure, provided that, if said failure is of a nature that the same cannot be completely cured or remedied within said thirty (30) day period, then Tenant shall not be in default if it begins such cure
within the thirty (30) day period described above and thereafter diligently prosecutes such cure to completion. 
 I. Any lien,
attachment or other encumbrance is lodged against the Leased Premises, Building 5 or the Property by a party claiming through or under Tenant and such is not discharged within sixty (60) days after Tenant’s receipt, whether actual or
statutory, of such lien, attachment or encumbrance. 
 17.2 Termination Upon Occurrence of Event of Default. Upon the
occurrence of an Event of Default, this Lease and the Term thereof may, at the option of Landlord and upon fifteen (15) days’ written notice, terminate and expire and, upon such termination, Tenant shall forthwith quit and surrender the
Leased Premises to Landlord but still shall remain liable to Landlord as herein provided. 
 17.3 Effect of Termination. Upon
termination as provided for in this Article 17, Landlord may dispossess Tenant by summary process or otherwise in accordance with applicable law, and Tenant hereby waives the service of any notice to quit. 

  
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 17.4 Damages. In the case of any termination of this Lease under this Article 17,
Landlord, at its sole discretion, may recover from Tenant any and all actual damages sustained by Landlord as a result of the termination and any re-letting of the Leased Premises. These damages include, but
are not limited to: 
  

	 	A.	 Base Rent and Additional Rent when due; 

 

	 	B.	 The cost of removing Tenant and its property and otherwise recovering the Leased Premises;

  

	 	C.	 The reasonable cost of preparing the Leased Premises for another tenant; 

 

	 	D.	 Reasonable brokerage appraisal fees; 

 

	 	E.	 Any other reasonable expenses as Landlord may incur in connection with reletting the Leased Premises.

  

	 	F.	 As an alternative to the damages described in clause “A” of this Section 17.4, the difference
between (i) all Base Rent and Additional Rent which would have become payable for the remainder of the Term of this Lease, and (ii) that actually received for said period, all of which shall be discounted to present value using Federal
Reserve discount rate; and 

  

	 	G.	 Reasonable legal fees incurred by Landlord in exercising its rights under this Article 17.

 17.5 Mitigation of Damages. Landlord shall use reasonable efforts to mitigate its damages. Provided that
Landlord has used reasonable efforts to mitigate its damages, the failure or inability of Landlord to re-let the Leased Premises, or any part or parts thereof, or the failure or inability to collect rentals
equal to the rentals payable under this Lease shall not release or affect Tenant’s liability for damages. In no event shall Tenant be entitled to receive any excess, if any, of any such rents collected over the sums payable by Tenant to
Landlord under this Lease. 
 17.6 Use and Occupancy. Any monies received by Landlord from or on behalf of Tenant during the
pending of any proceeding of the types referred to in subsections 17.1.B and 17.1 C shall be deemed paid as compensation for the use and occupation of the Leased Premises, and the acceptance of any such compensation by Landlord shall not be deemed
an acceptance of Base Rent and/or Additional Rent or a waiver on the part of the Landlord of any rights under Article 17. 

  
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 ARTICLE 18. LANDLORD’S PERFORMANCE ON TENANT’S BEHALF 

18.1 Landlord May Cure Default. If Tenant defaults under this Lease, Landlord, at its sole option, following any required notice
and cure period, immediately or at any time thereafter, may elect to correct the default on behalf of Tenant. Any costs or expenses incurred 
 by Landlord
in curing such default including, but not limited to, fines, penalties, interest, damages and reasonable attorney’s fees in instituting, prosecuting or defending any action or proceeding, all of which sums shall carry interest at the lesser of
18% per annum or the highest rate permitted by law until paid in full, shall be deemed to be Additional Rent. Tenant shall pay such sums within thirty (30) days of rendition of a reasonably detailed bill or statement to Tenant therefor. Upon
payment of such bill, Tenant shall be deemed to have cured such default. 
 18.2 Landlord Not Obligated to Cure Default.
Nothing contained in this Article shall be construed as to require Landlord to incur any expenses or obligations on behalf of Tenant. 

ARTICLE 19. TENANT’S QUIET ENJOYMENT OF THE LEASED PREMISES 

So long as no uncured Event of Default exists, Tenant may peaceably and quietly have, hold and enjoy the Leased Premises for the Term of this
Lease subject to the provisions of this Lease. 
 ARTICLE 20. NO WAIVER BY LANDLORD 

20.1 No Waiver. If either Landlord or Tenant fails or decides not to enforce any provision of this Lease or Landlord fails or
decides not to enforce any of the rules and regulations of Landlord set forth in this Lease or hereafter adopted, on any occasion, it may nevertheless on another occasion enforce such provision, rule or regulation. No act by Landlord or
Landlord’s agents shall be deemed an acceptance of a surrender of the Leased Premises or a waiver of any right under the Lease unless Landlord has so agreed in writing. 

20.2 Accepting Money Not a Waiver. Landlord will not waive any right to enforce any provision of this Lease by accepting a
payment of Base Rent and/or Additional Rent from Tenant knowing that Tenant has failed to comply with the terms of the Lease. No endorsement or statement on any check or any letter accompanying any check or payment shall be deemed to effect an
accord and satisfaction and Landlord may accept any such check or payment without prejudice to Landlord’s right to recover the balance of such Base Rent and/or Additional Rent or payment due or pursue any other remedy in this Lease provided.

 ARTICLE 21. INABILITY TO PERFORM 

This Lease and the obligation of Tenant to pay Base Rent and/or Additional Rent and other payments required hereunder and comply with all of
the other provisions of this Lease shall in no way be affected, impaired or excused because Landlord is delayed in supplying any service expressly or implied to be supplied, or is unable to make or is delayed in making any repair, additions,
alterations or decorations, or is unable to supply or is delayed in supplying any equipment or fixtures, or is unable to fulfill or is delayed in fulfilling any other obligation hereunder, if Landlord is so prevented or delayed by reason of riot,
strike, labor troubles, war, act of God or any other cause whatsoever beyond Landlord’s reasonable control not including mere 

  
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 lack of funds including, but not limited to, government preemption in connection with a national emergency or by
reason of any rule, order or regulation of any department or subdivision thereof of any government agency, or by reason of the conditions of supply and demand which have been or are affected by war or other emergency; provided, however, that
Landlord shall give written notice to Tenant of a claim of a force majeure delay within thirty (30) days after Landlord first becomes aware of the occurrence of the event of force majeure, and, provided, further, that if the
force majeure delay shall exceed one hundred twenty (120) days, then in such event Tenant may terminate this Lease by written notice given to Landlord within five (5) days of the expiration of said
120-day period. 
 Notwithstanding the foregoing, if the Leased Premises, or a material portion of
the Leased Premises, are made untenantable for a period in excess of five (5) consecutive Business Days as a result of a Landlord’s failure to furnish, or any interruption, diminishment or termination of services due to the application of
Laws, the failure of any equipment, the performance of maintenance, repairs, improvements or alterations, utility interruptions (collectively a “Service Failure”) that is reasonably within the control of Landlord to correct,
including lack of funds then Tenant shall be entitled to receive an abatement of Base Rent and/or Additional Rent payable hereunder during the period beginning on the first day after the expiration of such fifth (5lh) Business Day period and ending on the day the service has been restored. If the entire Leased Premises have not been rendered untenantable by the Service Failure, the amount of abatement shall be
equitably prorated. 
 ARTICLE 22. NOTICES AND OTHER COMMUNICATIONS 

Any and all notices, demands or other communication permitted or required by this Lease to be given to either party shall be deemed
sufficiently given if in writing and delivered personally (and for which delivery a signed receipt is given) or sent by commercial overnight courier or by registered or certified mail, return receipt requested, postage prepaid, if to Landlord
addressed to 5 Science Park, New Haven, CT 06511 , and if to Tenant addressed to the address of the Leased Premises. Any such notice, demand or other communication that is delivered personally (and for which a signed receipt is given) shall be
deemed given and received as of the date of delivery. Any such notice, demand or other communication that is sent by commercial overnight courier or by registered or certified mail, return receipt requested, shall be deemed given and received on the
date of delivery or refusal thereof. Either party may specify a different address by giving the other party notice of such different address according to the terms of this Article. 

ARTICLE 23. RULES AND REGULATIONS 

23.1 Compliance with Rules and Regulations. Tenant and Tenant’s servants, employees, agents, contractors, subcontractors,
licensees and invitees shall faithfully observe and comply strictly with the reasonable rules and regulations for occupancy of the Leased Premises promulgated from time to time by Landlord and communicated in writing by Landlord to Tenant not
inconsistent with the terms of this Lease. The current rules and regulations in effect are attached hereto and made a part hereof as Schedule D. 

  
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 23.2 Notice of Change. Landlord shall give Tenant thirty (30) days written
notice of any changes in Schedule D or of any additional reasonable rules or regulations to be adopted not inconsistent with the terms of this Lease. 

23.3 Landlord Under No Duty to Enforce Rules and Regulations. Landlord has no duty to enforce the rules and regulations or
provisions of any other Lease as against any other tenant provided Landlord will not enforce rules only against Tenant in a discriminatory fashion, and Landlord shall not be liable to Tenant for the violation of such rules, regulations or Leases by
any other tenant, its servants, employees, agents, licensees or invitees. 
 ARTICLE 24. SECURITY DEPOSIT 

24.1 Security Deposit. Upon execution of this Lease, Tenant shall deposit with Landlord the sum of $17,336.00 (the
“Deposit”) as security for its faithful performance and observance of the provisions of this Lease. It is agreed that if an Event of Default shall occur, Landlord may use, apply or retain the whole or any part of the Deposit
to the extent required to compensate Landlord for damages incurred as a result of such default, for expenses of Landlord incurred in connection with curing such default or for paying any sum which Landlord may expend or may be required to expend by
reason of Tenant’s default. Tenant agrees that, upon demand by the Landlord, Tenant shall replenish such security deposit to the extent that it is drawn upon by the Landlord, from time to time. 

24.2 Return of Deposit; Successor Landlord. If Tenant fully and faithfully performs every provision of this Lease to be performed
by it, the Deposit or any balance thereof, less any sums then due Landlord from Tenant under this Lease, shall be returned to Tenant (or, at Landlord’s option to the last assignee of Tenant’s interest thereunder) within thirty
(30) days following the last to occur of (i) the passage of the Expiration Date or earlier termination pursuant to the terms hereof, provided that such early termination is not as a consequence of an Event of Default by Tenant,
(ii) Tenant’s vacating the Leased Premises, and (iii) the receipt by Landlord of all Cleaning Certificates and manifests with respect to the cleaning of the Leased Premises and remaining furnishings, fixtures and equipment required
pursuant to Article 8.7 hereof. In the event that Cleaning Certificates and manifests which are reasonably satisfactory to Landlord both in form and substance are not received by Landlord within forty five (45) days of the Expiration Date or
such earlier termination date, Landlord shall be authorized to utilize the Deposit to engage such appropriate contractors to perform Tenant’s obligations under Article 8.7 hereof. 

24.3 Transfer of Deposit to New Landlord. In the event of a sale of or upon a transfer of Landlord’s interest in Building 5
or the Property to another person, Landlord shall have the right to transfer the Deposit to the other person and Landlord upon doing so shall be released by Tenant from all liability for the return of the Deposit, provided Landlord notifies Tenant
of the name and address of such transferee and provides evidence of an assignment and assumption agreement executed by such transferee. Tenant agrees to look solely to the new landlord for the return of the Deposit. It is agreed that the provisions
of this Article shall apply to every transfer or assignment made of the Deposit to a new landlord. 

  
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 24.4 No Assignment by Tenant. Tenant will not assign the Deposit or use the Deposit
as collateral or attempt to so assign or use it. Neither Landlord nor its successors or assigns shall be bound by any assignment, encumbrance, attempted assignment or attempted encumbrance of the Deposit. 

24.5 No Interest on Deposit. No interest shall accrue on the Deposit to Tenant’s benefit. 

ARTICLE 25. INSURANCE 

25.1 Required Insurance. Tenant will maintain in full force and effect the following insurance: 

 

	 	A.	 Public liability insurance in an amount of $1,000,000 combined single limit death, bodily injury, personal
injury and property damage. 

  

	 	B.	 “All risk extended coverage insurance” insuring its personal property to be located on the Leased
Premises for full replacement value against loss by fire, vandalism, malicious mischief and other casualty. 

  

	 	C.	 Worker’s compensation insurance as required by law. 

25.2 Landlord and Landlord’s Lenders to be Named Additional Insureds. Tenant’s public liability insurance shall name
Landlord and Landlord’s Lenders and any public party required to be named, as designated by the holder of any mortgage on the Property, as an additional insured party. 

25.3 Waiver of Subrogation. Notwithstanding anything to the contrary contained herein, each party waives, and shall cause its
insurance carrier to waive, any right of recovery against the other for any loss of or damage to property which loss or damage is (or, if the insurance required hereunder had been carried, would have been) covered by all risk property insurance. For
purposes of this Section 25, any deductible with respect to a party’s insurance shall be deemed covered by, and recoverable by such party under, valid and collectable policies of insurance. 

25.4 Notice of Cancellation. Each insurance policy required to be maintained by Tenant hereunder must contain a provision that
the policy may not be canceled or modified without at least ten (10) days’ notice to Landlord. 
 25.5 Insurance
Companies. All insurance required to be maintained by Tenant hereunder will be provided by companies that are licensed to do business in Connecticut and have a Best’s Insurance rating of A- or better
and are otherwise reasonably acceptable to Landlord. 

  
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 25.6 Policies to be Delivered to Landlord. Tenant will give Landlord an original
certificate for each insurance policy before it occupies the Leased Premises and an original certificate of each renewal at least twenty (20) days before the expiration of the policy. 

25.7 Landlord’s Insurance. Landlord will maintain in full force and effect during the Term of this Lease: (i) “all risk
extended coverage” property insurance insuring Building 5 for its full replacement value, and (ii) public liability insurance in an amount of $1,000,000 combined single limit death, bodily injury, personal injury and property damage,
naming Tenant as an additional insured thereunder. Landlord’s policy of “all risk extended coverage insurance” will contain an agreement by the insurance company waiving its rights to recover against Tenant. 

ARTICLE 26. SERVICES PROVIDED BY LANDLORD 

26.1 Services. Landlord shall provide the following services to Tenant: 

 

	 	A.	 Landlord shall provide electricity, gas, and heat, ventilation and air conditioning (“HVAC”)
to Building 5 and the Leased Premises necessary to maintain a comfortable and customary temperature; 

  

	 	B.	 Landlord shall clean and maintain the common interior portions of Building 5; and 

 

	 	C.	 Landlord shall keep the roadways, sidewalks and parking areas serving Building 5 and the Leased Premises free
from snow, ice and all obstructions, and the grass and shrubbery properly maintained; 

  

	 	D.	 Landlord shall maintain and keep in good repair and efficient operation the utility and elevator systems and
the fire protection sprinkler systems serving Building 5 and the Leased Premises; 

  

	 	E.	 Landlord shall provide HVAC from 8:00 a.m. to 6:00 p.m., Monday through Friday, excluding holidays as set forth
on Exhibit B hereto. 

  

	 	F.	 Landlord shall provide hot and cold running water for Tenant’s use. Tenant will be billed separately for
extraordinary amounts which may be available at Landlord’s sole discretion; and 

  

	 	G.	 Landlord shall provide periodic manned security patrols at Building 5. Patrol intervals will be determined at
the sole discretion of the Landlord. 

  

	 	H.	 Landlord shall provide Tenant with access to Building 5 and the Leased Premises 24 hours a day, 7 days a week,
52 weeks a year. 

  
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	 	I.	 Landlord shall be responsible, at its sole cost, for compliance with all laws with respect to the Property and
Building 5 (excluding the Leased Premises, except as otherwise provided herein), including, without limitation, ADA, OSHA and local building and fire codes. 

26.2 Normal Operating Hours. Normal operating hours for Building 5 will be 8:00 a.m. to 6:00 p.m., Monday through
Friday, excluding holidays. If Tenant desires heating and/or air conditioning at other than established hours, Landlord, upon reasonable notice, shall so provide such service at the rate of $35 per hour (subject to reasonable increases from time to
time). 
 26.3 Services to Other Entities. No extra services shall be provided for the use of any entity other than Tenant
without Landlord’s prior express written consent. 
 ARTICLE 27. ADDITIONAL OBLIGATIONS OF TENANT 

27.1 Additional Obligations. In addition to its other obligations under this Lease, Tenant shall at its expense comply with the
following provisions with respect to the Leased Premises: 
  

	 	A.	 Tenant shall keep the Leased Premises in good order and free from all refuse, and shall promptly remove all
debris, garbage, and refuse of any kind from the Leased Premises; 

  

	 	B.	 Tenant shall be responsible for all desired painting and security services for the Leased Premises and all
janitorial services for the Leased Premises; 

  

	 	C.	 Tenant shall exercise commercially reasonable efforts in the prevention and extermination of vermin, rats, mice
or other pests in the Leased Premises; 

  

	 	D.	 Tenant shall maintain in good order and repair all laboratory equipment and fixtures that is not Tenant’s
property located in the Leased Premises; and 

  

	 	E.	 Tenant shall contract for and pay for the collection, removal and lawful disposal of all waste at the Leased
Premises containing or constituting Hazardous Materials. 

  
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 ARTICLE 28. SIGNS 

Tenant may display a sign at the entrance to the Leased Premises and shall also shall also have the right to install, at Tenant’s cost,
signage on the exterior of Building 5, subject to: (i) any required municipal approvals and/or permits, which approvals and/or permits shall be secured by Tenant at Tenant’s sole cost and expense; and (ii) Landlord’s approval as
to design, location and size of all signage, which consent shall not be unreasonably delayed or withheld. The Tenant, at Tenant’s cost, shall be listed in all directories maintained by Landlord with respect to Building 5. Except for the
foregoing permitted signage, Tenant shall not place any signs, lettering or advertisements anywhere on or in the Property or Building 5 or in the Leased Premises where such is visible from outside the Leased Premises, except as permitted by Landlord
in writing. 
 ARTICLE 29. BROKERAGE 

Tenant agrees to indemnify and hold Landlord harmless from and against the claims of any party claiming a fee or commission by, under or
through Tenant on account of this Lease other than Colliers International (the “Broker”). Tenant represents and warrants that no other party other than the Broker has any claim for a fee or commission by, under or through Tenant on account
of this Lease. Landlord represents to Tenant that no broker has an exclusive right to lease space at the Property and Landlord agrees to indemnify and hold Tenant harmless from and against the clams of any party claiming a fee or commission on the
basis that Landlord granted an exclusive listing agreement including Broker. Landlord shall pay brokerage fees to the Broker pursuant to a separate written agreement. 

ARTICLE 30. NOTICE OF LEASE 

Upon request of either party to the other, Landlord and Tenant agree to execute and record a statutory notice of Lease as provided in C.G.S. §47-19. 
 ARTICLE 31. SURRENDERING OF LEASED PREMISES 

31.1 Surrender of Leased Premises. Tenant will immediately surrender the Leased Premises upon the expiration or earlier
termination of this Lease for any reason. Tenant shall indemnify Landlord against loss or liability resulting from delay by Tenant in so surrendering the Leased Premises, including, but not limited to, reasonable attorney’s fees and any claims
made by any succeeding tenant founded on such delay. 
 31.2 Condition of Leased Premises. Upon the expiration of the Term or
sooner termination of this Lease, except where the Lease has been terminated because of fire or other casualty, Tenant shall leave the Leased Premises and surrender it to Landlord “broom clean” and in good order, condition and repair,
ordinary wear and tear excepted. 

  
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 31.3 Removal of Tenant’s Property. When Tenant surrenders the Leased Premises
to Landlord, Tenant shall, at Tenant’s expense, forthwith provide Cleaning Certificates and remove all personal property effects of Tenant and those of any other persons claiming under Tenant, from the Leased Premises, Building 5, the Property
and the real property known as “Science Park” of which the Property forms a part. Property not removed by Tenant within forty-eight (48) hours after termination of this Lease shall be deemed abandoned and Landlord may, at
Tenant’s expense, obtain Cleaning Certificates (if not previously provided by Tenant) and remove Tenant’s personal property effects from the Property and/or at Landlord’s option sell or otherwise dispose of the same with no obligation
to remit any portion of the proceeds of any such sale to Tenant. Tenant shall reimburse Landlord upon demand for all reasonable costs incurred by Landlord in obtaining Cleaning Certificates and in so removing and disposing of such property provided
Landlord furnishes reasonably supporting documentation in connection therewith. 
 31.4 Holding Over Shall Not Renew Lease.
Tenant’s occupancy of the Leased Premises beyond the Term of this Lease or after termination will not constitute a renewal of the Lease by operation of law or otherwise for any period whatsoever. If Tenant does so occupy the Leased
Premises, it shall be deemed to be a tenant at sufferance only and shall pay Landlord Base Rent and Additional Rent in an amount equal to one hundred fifty percent (150%) of the Base Rent and Additional Rent payable hereunder in the last year of the
initial Term or Extension Term, as the case may be, and shall be subject to all other provisions of this Lease. Regardless of any payment made by Tenant or any payment cycle, no holding over after receipt of notice of termination shall under any
circumstances be deemed any more than a tenancy at sufferance. 
 ARTICLE 32. ADDITIONAL OBLIGATIONS OF TENANT 

Tenant shall promptly reimburse Landlord, upon demand, for all reasonable out of pocket costs of Landlord, including reasonable
attorney’s fees, incurred in providing any consent or review of any sublease, mortgage or collateral assignment of Tenant’s Leasehold interest, requested of Landlord hereunder. 

ARTICLE 33. TENANT’S WAIVER OF RIGHTS 

In connection with any disputes and legal proceedings arising from this Lease, Tenant waives the following legal rights: 

33.1 PREJUDGMENT REMEDY, REDEMPTION, COUNTERCLAIM AND JURY TRIAL. THE TENANT, FOR ITSELF AND FOR ALL PERSONS CLAIMING THROUGH OR
UNDER IT, HEREBY ACKNOWLEDGES THAT THIS LEASE CONSTITUTES A COMMERCIAL TRANSACTION AS SUCH TERM IS USED AND DEFINED IN SECTION 52-278(A) OF THE CONNECTICUT GENERAL STATUTES, OR ITS SUCCESSOR PROVISIONS IF
AMENDED, AND HEREBY EXPRESSLY WAIVES ANY AND ALL RIGHTS WHICH ARE OR MAY BE CONFERRED UPON THE TENANT BY SAID ACT TO ANY NOTICE OR HEARING PRIOR TO A PREJUDGMENT REMEDY UNDER SECTIONS 52-278(A) TO 52-278(G), OR THEIR SUCCESSOR PROVISIONS IF AMENDED, INCLUSIVE OF SAID STATUTES SUCH WAIVER IS INTENDED AS A WAIVER IN ACCORDANCE WITH SECTION 52-278(F) OR ITS SUCCESSOR
PROVISIONS IF 

  
 34 

 AMENDED, OF SAID STATUTES. TENANT FURTHER WAIVES ANY AND ALL RIGHTS WHICH ARE OR MAY BE CONFERRED BY ANY PRESENT
OR FUTURE LAW TO REDEEM THE LEASED PREMISES, OR TO ANY NEW TRIAL IN ANY ACTION OF EJECTMENT UNDER ANY PROVISION OF LAW, AFTER RE-ENTRY THEREUPON, OR UPON ANY PART THEREOF, BY THE LANDLORD, OR AFTER ANY WARRANT
TO DISPOSSESS OR JUDGMENT IN EJECTMENT. IF THE LANDLORD SHALL ACQUIRE POSSESSION OF THE LEASED PREMISES BY SUMMARY PROCEEDINGS, OR IN ANY OTHER LAWFUL MANNER WITHOUT JUDICIAL PROCEEDINGS IT SHALL BE DEEMED A
RE-ENTRY WITHIN THE MEANING OF THAT WORD AS USED IN THIS LEASE. IN THE EVENT THAT LANDLORD COMMENCES ANY SUMMARY PROCEEDINGS OR ACTION FOR NON-PAYMENT OF RENT OR OTHER
CHARGES PROVIDED FOR IN THIS LEASE, THE TENANT SHALL NOT INTERPOSE ANY COUNTERCLAIM OF ANY NATURE OR DESCRIPTION IN ANY SUCH PROCEEDING OR ACTION. THE TENANT AND THE LANDLORD BOTH WAIVE A TRIAL BY JURY OF ANY AND ALL ISSUES ARISING IN ANY ACTION OR
PROCEEDING BETWEEN THE PARTIES HERETO OR THEIR SUCCESSORS, UNDER OR CONNECTED WITH THIS LEASE, OR ANY OF ITS PROVISIONS. 
 33.2
Waiver of Notice to Quit. The right to a formal demand to leave the Leased Premises upon expiration of this Lease by lapse of time, known as a “Notice to Quit”, or any other form of notice under
§47a-25 of the Connecticut General Statutes, should Landlord use summary process to evict Tenant or regain possession of the Leased Premises. 

33.3 Waiver of Right of Reinstatement. Any right, under existing or future law, to gain back the Leased Premises once Tenant is
legally removed (known as “Right of Reinstatement”). 
 ARTICLE 34. EFFECT OF WRITTEN LEASE AGREEMENT 

34.1 Written Lease Sole Expression of Parties’ Intent. All understandings, letters of intent or agreements between Tenant
and Landlord, which predate this Lease, are merged in this Lease. No oral statements or representations or prior written communications by or between the parties dealing with this Lease shall be binding or effective. This Lease is the sole and
complete expression of the agreement between Landlord and Tenant as to the subject matter of this Lease. 
 34.2 Amendment of
Written Lease. This Lease can be modified, altered or amended only by a written agreement signed by both Landlord and Tenant. 

  
 35 

 ARTICLE 35. OPTION TO EXTEND 

35.1 Option to Extend. Provided Tenant is not in default in its obligations hereunder beyond any applicable cure period, Tenant
shall have the option to extend this Lease for one additional successive term (hereinafter referred to, as applicable, as the “Extended Term”) commencing immediately upon the expiration of the initial Term hereof and
continuing for a period of five (5) years, provided that Tenant proceeds strictly in accordance with the provisions of this Article 35. On or before the date that is one hundred twenty (120) prior to the Expiration Date for the Term (the
“Notice Date”), Tenant shall advise Landlord in writing that Tenant wishes to extend the term of this Lease (hereinafter referred to as “Tenant’s Extension Notice”). If at the time Landlord receives
Tenant’s Extension Notice this Lease is in full force and effect without default on the part of the Tenant beyond any applicable cure period, then, during the next thirty (30) days, Landlord shall notify Tenant in writing of the Base Rent
pursuant to Article 3 of the Lease which shall be due for the Extended Term. The Base Rent specified by Landlord shall be equal to the greater of: (a) the Base Rent scheduled to be paid for the last year of the Term without giving effect to any
partial or complete abatements of Base Rent (the “Rent Notice”); or (b) ninety five percent (95%) Landlord’s projected fair market Base Rent as of the commencement of the Extended Term, for comparable space in comparable
buildings in New Haven (the “FMV Rent Notice”). 
 35.2 Base Rent for the Extended Term. (a) If
the Landlord sends a Rent Notice, the Base Rent for the Extended Term shall be as set forth in the Rent Notice and consistent with Section 35.1 above. 

(b) If the Landlord sends a FMV Rent Notice, the Tenant shall have 21 days after receipt of the FMV Rent Notice in which to send Landlord a
written dispute as to the proposed Base Rent specified in the FMV Rent Notice. If Tenant agrees to pay such new Base Rent or if Tenant does not send a written dispute of the new Base Rent specified in the FMV Rent Notice within such 21 day period,
Tenant shall be deemed to have agreed to pay such Base Rent. If Tenant sends Landlord a written dispute as to the Base Rent proposed in the FMV Notice, the Base Rent for the Extended Term shall be determined pursuant to the arbitration system set
forth in Article 35.3 below. 
 35.3 Arbitration of Fair Market Rent. In the event that Tenant sends written notice to Landlord
disputing the FMV Rent Notice within 21 days of Tenant’s receipt of the FMV Rent Notice, each of Landlord and Tenant shall, at its own respective cost and expense, retain a real estate broker, who must have ten (10) years of experience in
commercial leasing in the New Haven market, to determine the fair market Base Rent for the Leased Premises as of the commencement date of the First Extended Term or Second Extended Term, as applicable, which appraisals must be completed and
submitted within thirty (30) days of the commencement of the appraisal process by Tenant’s notice electing arbitration. If the two appraisals are within ten percent (10%) of each other, then the average of the two appraisal amounts shall
constitute the Base Rent which shall be due during the Extended Term. If the two appraisals are not within ten percent (10%) of each other, the two brokers shall select a third real estate broker (who must also possess the minimum qualifications
described above), who within the next thirty (30) days shall select one of the two appraisal amounts which shall then constitute the Base Rent which shall be due during the Extended Term. Landlord and Tenant shall each bear one-half of the cost of said third broker. The appraisal process shall be binding upon both Landlord and Tenant. 

  
 36 

 35.4 Extended Term. Upon determination of the Base Rent for the Extended Term
pursuant to Section 35.2 and 35.3 of this Lease, as applicable, this Lease shall be extended for the Extended Term, without the execution of any additional documents, and each and every term and condition of this Lease shall apply during the
Extended Term, except only that: (i) the Base Rent specified in Article 3 of this Lease during the Extended Term shall be as determined above, and (ii) the phrase “term of this Lease” and “Term” shall be construed to
include the Extended Term and thus the new Expiration Date shall be the last day of the Extended Term. 
 35.5 Failure to Exercise
Option. If Tenant shall fail to give Landlord written notice of Tenant’s exercise of the Extended Term on or before the applicable Notice Date, time being of the essence, Tenant shall have no right to extend this Lease for the Extended Term
and this Lease shall terminate as provided in Article 3 of this Lease and Tenant shall vacate the Leased Premises on or before the Expiration Date in accordance with the provisions of this Lease. 

ARTICLE 36. INTERPRETATION OF LEASE; MISCELLANEOUS 

36.1 Partial Invalidity. If any of the provisions of this Lease, or its application, is held by any court or in arbitration to
be invalid or inapplicable, such decision shall not affect any other term, provision, covenant or condition of this Lease. Notwithstanding the foregoing, if the invalid provision has the effect of reducing the Base Rent and/or Additional Rent to be
paid by Tenant, Landlord may cancel this Lease. 
 36.2 Article and Section Captions. Article and section captions will not be
given any effect in determining the meaning of this Lease. 
 36.3 Governing Law. The laws of the State of Connecticut will
govern the interpretation of this Lease. 
 36.4 Successors and Assigns. This Lease shall be binding upon the parties hereto
and upon their heirs, administrators, executors, successors and assigns. 
 36.5 Continuing Obligations. Notwithstanding
anything to the contrary contained herein, all of Tenant’s and Landlord’s respective continuing rights, remedies, obligations and liabilities under Section 8.7, Section 8.8, Section 11.4, Article 12, Article 29 and Article
31 of this Lease, to the extent they are intended, by their terms, to survive, shall survive the Expiration Date or the earlier termination of this Lease for any reason. 

36.6 Landlord’s Liability. In the event of a ground lease, sale, transfer or conveyance by Landlord of Building 5, the same
shall operate to release Landlord from any future liability for any of the obligations, covenants or conditions, express or implied, herein contained, provided the purchaser, ground lessee or transferee assumes Landlord’s obligations and
covenants hereunder. In such event, Tenant agrees to look solely to the responsibility of the successor in interest of Landlord in and to this Lease. 

  
 37 

 Landlord and Landlord’s officers, directors, shareholders and agents shall have absolutely
no personal liability with respect to any provision of this Lease or any obligation or liability arising from this Lease or in connection with this Lease in the event of a breach or default by Landlord on any of its obligations. Tenant shall look
solely to the equity of the Landlord in the Property and Building 5 at the time of the breach or default for the satisfaction of any remedies of Tenant, and shall have no recourse against any other assets of Landlord or against any assets of any
officer, director, shareholder or agent of Landlord. Such exculpation of liability shall be absolute and without any exception whatsoever. 

36.7 Existing Lease. Landlord and Tenant are currently parties to a lease executed by Landlord on July 13, 2013 and by
Tenant on July 22, 2013, as amended from time to time, with respect to the Third Floor Premises and the Second Floor Premises (the “Existing Lease”). Landlord and Tenant agree that the Existing Lease shall be deemed terminated
as of 1 1:59 p.m. on December 31, 2017, and all of Tenant’s obligations thereunder shall be satisfied in full upon the full execution and delivery of this Lease excepting only Tenant’s indemnity obligations under the Existing Lease
and such other provisions that expressly survive the expiration or earlier termination of the Lease. Landlord specifically agrees that this Lease shall constitute a “Qualifying Extension” and thus Tenant’s obligation to make a “One-Time Improvement Payment” (as each are defined in the Existing Lease) shall be satisfied and discharged upon the full execution and delivery of this Lease. 

36.8 Replacement Premises. In the event that Landlord and Tenant agree to construct a headquarters facility for Tenant at Science
Park Tract A. (“Tract A Headquarters”) which is ready for occupancy by Tenant within the Term or Extended Term of this Lease, as the case may be, Landlord and Tenant agree to terminate this Lease as of the first day of the
month immediately following the later of the date by which Tenant: (a) has completed moving into the Tract A Headquarters; and (b) has finally and completely vacated and surrendered possession of the Leased Premises to Landlord. 

36.9 Counterparts. This Lease may be executed in counterparts and each counterpart shall be deemed to be an original instrument,
but all such counterparts together shall constitute but one agreement. 
 [The Signature Page Immediately Follows.] 

  
 38 

 IN WITNESS WHEREOF, the parties hereto have hereunto set their hands and seals as of the day and
year first above written. 
  

			
	TENANT:
	
	ARVINAS, INC.
		
	By:	 	 /s/ Sean Cassidy

		 	CFO & Treasurer
	
	LANDLORD:
	
	SCIENCE PARK DEVELOPMENT CORPORATION
		
	By:	 	 /s/ Clio Nicolakis

		 	Clio Nicolakis
		 	Executive Director

  
 39 

					
	 STATE OF CONNECTICUT)

                          
                      )
 COUNTY OF NEW
HAVEN)
	  	ss: New Haven	  	January 2, 2018

 On this date personally appeared before me Sean Cassidy, who acknowledged himself/herself to be the
duly authorized                                 of Arvinas, Inc., a Delaware corporation,
and that the execution hereof was the free act and deed of such corporation and his/her free act and deed as such officer. 
 IN WITNESS
WHEREOF, I hereunto set my hand 
  

			
	JESSIE M. CRUZ	  	 /s/ Jessie M. Cruz

	NOTARY PUBLIC	  	Commissioner of the Superior Court/
	State of Connecticut	  	Notary Public
	 My Commission Expires
 6/30/2021
	  	

  

					
	 STATE OF CONNECTICUT)

                          
                      )
 COUNTY OF NEW
HAVEN)
	  	ss: New Haven	  	December 26, 2018

 On this date personally appeared before me Clio Nicolakis, who acknowledged himself to be the duly authorized
Exec Director of the Board of Science Park Development Corporation, a corporation, and that the execution hereof was the free act and deed of such corporation and his/her free act and deed as such officer. 

IN WITNESS WHEREOF, I hereunto set my hand 
  

	
	 /s/ David Silvertone

	Commissioner of the Superior Court/
	Notary Public

  
 40 

 EXHIBIT A 

LEGAL PROPERTY DESCRIPTION - 395 WINCHESTER AVENUE 

All that certain piece or parcel of land, together with all buildings and improvements thereon, situated in the City of New Haven, County of New Haven and
State of Connecticut, being shown as “Land of Science Park Development Corporation AREA = 2.775 ACRES”, on a certain map or plan entitled “Boundary Survey Portion of Parcel 5 Science Park Winchester Avenue, New Haven,
Connecticut,” prepared by URS GREINER, INC. A.E.S. 500 Enterprise Drive, Rocky Hill. CT 06067-4002, Scale: 1”=20’, Date: August, 1998, Map File #T140-52, Revision #1 10-21-98, Revision #2 11-17-98, Revision #3 11-24-98, which map is on file or to be filed in the New Haven City Clerk’s Office, and to which reference may be had for a more particular description thereof. 

Said premises are more particularly bounded arid described as follows: 

Commencing at an iron pin set in the Easterly street line of Winchester Avenue, which iron pin marks the Northwesterly corner of the herein
described premises and which point lies 344.11 feet from the Southeast intersection of said Winchester Avenue and Division Street, as shown on said map; 

Thence proceeding South 75° 38’ 10” East along land n/f Science Park Development Corporation shown as Parcel SP-1-C-2, a distance of 328.95 feet to a point marked by a drill hole, which point marks the Northeasterly corner of the herein
described premises; 
 Thence proceeding South 14° 21’ 20” West along land n/f Science Park Development Corporation shown as
Portion of Parcel SP-1-13-1, a distance of 367.43 feet to an iron pin, which pin marks the Southeasterly corner of the herein
described premises; 
 Thence proceeding North 75° 37’ 30” West along land n/f U.S. Repeating Arms Company Inc., a distance of
329.05 feet to a drill hole set in the easterly Street line of Winchester Avenue, which point marks the Southwesterly comer of the herein described premises; 

Thence proceeding North 14° 22’ 30” East along the Easterly street line of Winchester Avenue, a distance of 367.3 7 feet to the
point or place of beginning. 
 Together with the terms of two agreements concerning a portion of Winchester Avenue situated between Munson Street and
Division Street, one such agreement by and between Olin Corporation and Repeating Arms Company, dated July 20, 1981 and recorded in Volume 2922 at page 278 of said Land Records, and the other by and between Olin Corporation and City of New
Haven, dated May 14, 1984 and recorded in Volume 3211 at page 202 of said Land Records. 

 EXHIBIT B 

Holidays: 
 Martin Luther King, Jr. Day 

President’s Day 
 Good Friday 

Memorial Day 
 Independence Day 

Labor Day 
 Columbus Day 

Thanksgiving Day 
 Day after Thanksgiving 

Christmas Day 
 New Year’s Day 

 SCHEDULE A-1 

FLOOR PLAN OF FIRST FLOOR PREMISES 
  

 

 SCHEDULE A-2 

FLOOR PLAN OF SECOND FLOOR PREMISES 
  

 

 SCHEDULE A-3 

FLOOR PLAN OF THIRD FLOOR PREMISES 
  

 

 SCHEDULE A-4 

LANDLORD’S ADDITIONAL PROPERTY 
 3rd floor lab 
  

	1.	 laboratory casework 

  

	2.	 laboratory work stations/benches 

 

	3.	 Audio (paging) system 

 

	4.	 Autoclave unit(s) and ancillary systems 

 

	5.	 Glass wash unit(s) and ancillary systems 

 

	6.	 Biosafety cabinets 

  

	7.	 Controlled environment room 

 

	8.	 DI/RO water system 

  

	9.	 Kewaunee fume hood and ancillary systems and ventilation 

 

	10.	 Security and alarm system 

 

	11.	 Vacuum pump 

  

	12.	 A.O. Smith dedicated water heater 

 

	1.	 built-in reception desk 

2nd floor offices 
  

	1.	 cubicle workstation 

 

	2.	 office furniture including desks, some chairs, shelving and whiteboards 

 

	3.	 kitchen equipment 

1st floor office area 
  

	1.	 built-in reception desk 

 

	2.	 2 large wood wall partitioned private offices with u-shaped desks and
overhead bins 

  

	3.	 3 cubicle u-shaped workstations with overhead bins

  

	4.	 office furniture in 8 offices (2 offices without) 

 

	5.	 whiteboards 

  

	6.	 conference table 

  

	7.	 kitchen with dishwasher and refrigerator 

 

	8.	 keycard access system 

 

	9.	 server room with one switch rack and one shelving unit 

1st floor lab 
  

	1.	 laboratory work stations/benches 

 

	2.	 Tissue culture hood (6 ft Nuaire biosafety cabinet), ducted outside 

 

	3.	 2 ft x 4 ft exhaust hood in rear room 

 

	4.	 built-in lab glassware cabinet 

 

	5.	 4 ft Safeaire chemical hood 

 

	6.	 walk in +4 cold room 

 SCHEDULE B 

TENANT’S EQUIPMENT 
  

					
	FURNFIX	  	1	  	Office Suite of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	Office Suite of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	Office Suite of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	Office Suite of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	PhD Room of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	PhD Room of Furniture-Inv#s 14219,
	FURNFIX	  	1	  	Computational Chemist RM-Inv#s 14219,
	FURNFIX	  	1	  	Large Conference Suite-Inv#s 14219,
	FURNFIX	  	1	  	Small Conference Suite-Inv#s 14219,
	FURNFIX	  	1	  	Reception Area-Inv#s 14219,
	FURNFIX	  	1	  	Refrigerator—Lunch Room
	FURNFIX	  	1	  	Ikea desk (Taavi) & Ikea Lounge Chair
	FURNFIX	  	1	  	Ikea Loveseat for Reception Area
	FURNFIX	  	1	  	CEO Office, Conf Rm, Chem VP & CSO
	FURNFIX	  	1	  	Reception Desk
	FURNFIX	  	1	  	Conference Table & Furniture
	FURNFIX	  	1	  	(6) Storage Racks, (2) metal carts &
	FURNFIX	  	1	  	Refrigerator—Lunch room
	FURNFIX	  	1	  	Office Suite of Furniture
	FURNFIX	  	1	  	Office Suite of Furniture
	FURNFIX	  	1	  	File Cabinet—Kari
	FURNFIX	  	1	  	Elliptical
	FURNFIX	  	1	  	Treadmill
	FURNFIX	  	1	  	Office Suite of Furniture
	FURNFIX	  	1	  	Conference Table
	LABEQUIP	  	1	  	New Brunswick Incubator Shaker
	LABEQUIP	  	1	  	VWR CryoPro
	LABEQUIP	  	1	  	Fisher Scientific Isotemp Water Bath
	LABEQUIP	  	1	  	Fisher Scientific Isotemp Incubator
	LABEQUIP	  	1	  	Heraeus Biofuge pico
	LABEQUIP	  	1	  	Heraeus Biofuge pico
	LABEQUIP	  	1	  	Fisher Sci Electrophoresis Power Supply
	LABEQUIP	  	1	  	Denver Instrument Balance
	LABEQUIP	  	1	  	Sorvall RC-SB Plus Centrifuge
	LABEQUIP	  	1	  	Hoshizaki Ice Machine
	LABEQUIP	  	1	  	Baker Cell Culture Hood
	LABEQUIP	  	1	  	Baker Cell Culture Hood
	LABEQUIP	  	1	  	Baker Cell Culture Hood

					
	 LABEQUIP
	  	1	  	Thermo Scientific CO2 Incubator
	 LABEQUIP
	  	1	  	Thermo Scientific CO2 Incubator
	 LABEQUIP
	  	1	  	Thermo Scientific Precision Water Bath
	 LABEQUIP
	  	1	  	Sorvall ST 16 Centrifuge
	 LABEQUIP
	  	1	  	New Brunswick Ultra-Low Freezer
	 LABEQUIP
	  	1	  	Kenmore Refridgerator
	 LABEQUIP
	  	1	  	M-20 Microplate Swing Bucket Rotor
	 LABEQUIP
	  	1	  	Bio Rad T100 Thermal Cycler
	 LABEQUIP
	  	1	  	Bio RadT100 Thermal Cycler
	 LABEQUIP
	  	1	  	Bio Rad C1000Touch Thermal Cycler
	 LABEQUIP
	  	1	  	Gel Plate Blot System
	 LABEQUIP
	  	1	  	Benchmark Everlast Platform Rocker
	 LABEQUIP
	  	1	  	Benchmark Everlast Platform Rocker
	 LABEQUIP
	  	1	  	Bio Rad Cell Counter
	 LABEQUIP
	  	1	  	ChemiDoc MP Imaging System
	 LABEQUIP
	  	1	  	Cytation 3 Imaging Reader
	 LABEQUIP
	  	1	  	Synergy 2 Microplate Reader
	 LABEQUIP
	  	1	  	Branson Sonicator 200 Watt
	 LABEQUIP
	  	1	  	Thermo Scientific Orion Star A111
	 LABEQUIP
	  	1	  	PolyFlow Dry Ice Box
	 LABEQUIP
	  	1	  	Nikon Eclipse TS100 Microscope
	 LABEQUIP
	  	1	  	HP Compaq Elite 8300 & Monitor
	 LABEQUIP
	  	1	  	HP Compaq Elite 8300 & Monitor
	 LABEQUIP
	  	1	  	HP Compaq Elite 8300 & Monitor
	 LABEQUIP
	  	1	  	Gelman Dry Ice Chest w/Handles
	 LABEQUIP
	  	1	  	FlowCytometer & Assembly Pump
	 LABEQUIP
	  	1	  	Spectr TD2000E Trans llluminator
	 LABEQUIP
	  	1	  	(16) Xplorer 12-channel Pipettes
	 LABEQUIP
	  	1	  	(2) Eppend Res Plus Trade-In 12 chan
	 LABEQUIP
	  	1	  	(3) Eppend Res Plus Trade-In 12 chan
	 LABEQUIP
	  	1	  	(3) Eppend Res Plus Trade-In 12 chan
	 LABEQUIP
	  	1	  	Eppend Research plus 3-pack
	 LABEQUIP
	  	1	  	(4) Xplorer Charging Carousel
	 LABEQUIP
	  	1	  	VWRSymphony-3074 CO2 Incubator &
	 LABEQUIP
	  	1	  	Liquid Dispensing System
	 LABEQUIP
	  	1	  	Micro Plate Dispenser
	 LABEQUIP
	  	1	  	Titer Plate Shaker
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf

					
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Eppendorf
	 LABEQUIP
	  	1	  	Centrifuge-Beckman Allegra X22
	 LABEQUIP
	  	1	  	Inverted Microscope—Nikon Eclipse TS100
	 LABEQUIP
	  	1	  	Branson 450 Ultrasonic Processor
	 LABEQUIP
	  	1	  	Recirculating Hood (60
	 LABEQUIP
	  	1	  	Compound storage system
	 LABEQUIP
	  	1	  	Recirculating Hood (72
	 LABEQUIP
	  	1	  	(9) Pipettes UL Single channel &
	 LABEQUIP
	  	1	  	Pippetts research plus
	 LABEQUIP
	  	1	  	Pippetts research plus
	 LABEQUIP
	  	1	  	DualStack 3110/Rel#8 Series-II Water
	 LABEQUIP
	  	1	  	NBS TCA-3, Temp Monitoring System
	 LABEQUIP
	  	1	  	Nikon Microscope SMZ645
	 LABEQUIP
	  	1	  	Upgrade of Cytation 3 Imaging Reader
	 LABEQUIP
	  	1	  	V-10, dual pump, Carousel drive only
	 LABEQUIP
	  	1	  	(6) Xcell4 Midi-cell upgrade kits
	 LABEQUIP
	  	1	  	Nemi Guillotine
	 LABEQUIP
	  	1	  	Dell Laptop w/ Biocore EvaI Software
	 LABEQUIP
	  	1	  	Dell Laptop w/ Unicom Software
	 LABEQUIP
	  	1	  	Filter Exc/emission 570/100NM, 680/30NM
	 LABEQUIP
	  	1	  	Filter blk asby
	 LABEQUIP
	  	1	  	Svce kit upgrade S2
	 LABEQUIP
	  	1	  	Filter Exc/emission
	 LABEQUIP
	  	1	  	(3) TI Explorer
	 LABEQUIP
	  	1	  	Cuvette Quartz w/ stopper
	 LABEQUIP
	  	1	  	(2) TI Xplorer Pipettes
	 LABEQUIP
	  	1	  	Superdex200, Superdex75 10/300 GL
	 LABEQUIP
	  	1	  	(2) TI Explorer 12-Channel 5-100ul yello
	 LABEQUIP
	  	1	  	(3) Res+ 0.5-10 ul 12-chan pipette &
	 LABEQUIP
	  	1	  	TI Xplorer 12-channel 50-1200ul green
	 LABEQUIP
	  	1	  	Nuaire Biosafety & Cell Culture Hood;
	 LABEQUIP
	  	1	  	Improvement to Air Clean Hood
	 LABEQUIP
	  	1	  	(2) Pump Dual Syring Infusion 115V
	 LABEQUIP
	  	1	  	Ergo One .5-10UL 12-channel pipet & ERGO
	 LABEQUIP
	  	1	  	iBlot 2 Gel Transfer Device
	 LABEQUIP
	  	1	  	1240 B SLM Aminco French Press
	 LABEQUIP
	  	1	  	Flow Jo v10 Dongle
	 LABEQUIP
	  	1	  	(4) Surelock Xcell Mini-Cell
	 LABEQUIP
	  	1	  	Ergo one 8 channel pipette (returned)
	 LABEQUIP
	  	1	  	Ergo one 12 channel St
	 LABEQUIP
	  	1	  	(4) Ergo One Starter Kit*5 SingleChannel
	 LABEQUIP
	  	1	  	Beckman Allegra 6 Centrifuge & Rotor

					
	 LABEQUIP
	  	1	  	Biacore 3000 Esscare
	 LABEQUIP
	  	1	  	Vertical Midi-Format Electrophoresis
	 LABEQUIP
	  	1	  	Refridgerator—Kenmore
	 LABEQUIP
	  	1	  	Labrepco Freezer
	 LABEQUIP
	  	1	  	Labrepco Refridgerator
	 LABEQUIP
	  	1	  	CombiFlash Rf-200i Automated Flash
	 LABEQUIP
	  	1	  	CombiFlash Rf 4x Module
	 LABEQUIP
	  	1	  	Discover SP microwave system
	 LABEQUIP
	  	1	  	Buchi Rotavapor
	 LABEQUIP
	  	1	  	SCILOGEX Rotary Evaporator
	 LABEQUIP
	  	1	  	Edwards RV8 Rotary Vane Dual
	 LABEQUIP
	  	1	  	Edwards RV3 Vacuum Pump
	 LABEQUIP
	  	1	  	SAVANT VLP120 Valupump
	 LABEQUIP
	  	1	  	SCILOGEX-Pro LCD Digital
	 LABEQUIP
	  	1	  	Buchi Vacuum Pump with
	 LABEQUIP
	  	1	  	Mettler Toledo Precision Balance
	 LABEQUIP
	  	1	  	American Scientific Balance
	 LABEQUIP
	  	1	  	Marble Balance Table
	 LABEQUIP
	  	1	  	Mettler Toledo Classic
	 LABEQUIP
	  	1	  	Mettler Toledo Balance
	 LABEQUIP
	  	1	  	VWR Benchtop Gravity Convection Oven
	 LABEQUIP
	  	1	  	Stainless Steel Desicator Cabinet
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	IKA Hotplate Magnetic Stirrer
	 LABEQUIP
	  	1	  	Computational Chemistry Computer
	 LABEQUIP
	  	1	  	Thermo Sci -Vacuum Oven
	 LABEQUIP
	  	1	  	Nitroflow Lab Generator
	 LABEQUIP
	  	1	  	Wilmad LG357-100-Dble Vacuum
	 LABEQUIP
	  	1	  	Wilmad LG357-100-Dble Vacuum
	 LABEQUIP
	  	1	  	12 Port Drying Chamber SS
	 LABEQUIP
	  	1	  	Freezone 2.5L Cascade Benchtop syst
	 LABEQUIP
	  	1	  	Gelman Ultrasonic Bath
	 LABEQUIP
	  	1	  	Fisher Hamilton Chemistry Hoods
	 LABEQUIP
	  	1	  	Mass Spec TOF LCMS
	 LABEQUIP
	  	1	  	High Performance Autosampler
	 LABEQUIP
	  	1	  	(2) Tissue Culture Hood
	 LABEQUIP
	  	1	  	(2) CO2 Incubator Double Stack
	 LABEQUIP
	  	1	  	ERGO once 12 Chan Adjustable Pipettors
	 LABEQUIP
	  	1	  	ERGO once 12 Chan Adjustable Pipettors

					
	 LABEQUIP
	  	1	  	ERGO once 12 Chan Adjustable Pipettors
	 LABEQUIP
	  	1	  	VIAFLO 96 Base Unit
	 LABEQUIP
	  	1	  	12.5ul 96 Channel Pipetting Head
	 LABEQUIP
	  	1	  	8 Channel Voyager Pipette
	 LABEQUIP
	  	1	  	12 Ch ViaFlo Pipette
	 LABEQUIP
	  	1	  	96 channel Pipetting Head Vioflow
	 LABEQUIP
	  	1	  	Kenmore 20.6 cubic ft Upright Freezer
	 LABEQUIP
	  	1	  	Microfuge-22R Centrifuge
	 LABEQUIP
	  	1	  	Mettler Toledo XS105 Balance
	 LABEQUIP
	  	1	  	Tissue Lyser Mill-Retsch Qaigen
	 LABEQUIP
	  	1	  	NUNC-Immuno Wash 12 for 96 well plates
	 LABEQUIP
	  	1	  	Trippt 51007 Lab Cart
	 LABEQUIP
	  	1	  	Pump Vacuum with Woulff Bottle
	 LABEQUIP
	  	1	  	Improvement to Air Clean Hood
	 LABEQUIP
	  	1	  	Auto Desiccator Cabinet
	 LABEQUIP
	  	1	  	bromoKdELECT Kds#32
	 LABEQUIP
	  	1	  	SALD 2300 wet measurement with
	 LABEQUIP
	  	1	  	Control Rct Saf Ikamag
	 LABEQUIP
	  	1	  	Oven 1.4 cu ft
	 LABEQUIP
	  	1	  	Rotavap
	 LABEQUIP
	  	1	  	HPLC (Software & Hardware)
	 LABEQUIP
	  	1	  	Ultrasonic Cleaner
	 LABEQUIP
	  	1	  	Repeater Stream Pipette
	 LABEQUIP
	  	1	  	Titan A450-Quad CPUs AMO Opteron Abu
	 LABEQUIP
	  	1	  	HPLC Replacement Parts
	 LABEQUIP
	  	1	  	Explosion Proof Freezer
	 LABEQUIP
	  	1	  	Digital Rocker 12V/US
	 LABEQUIP
	  	1	  	Vacuum Pump V-300
	 LABEQUIP
	  	1	  	Upright Freezer & Top Freezer/Refridge
	 LABEQUIP
	  	1	  	Li-Cor Odyssey 9120 Imaging System
	 LABEQUIP
	  	1	  	(2) Surelock Xcells
	 LABEQUIP
	  	1	  	Long Life Deuterium Lamp, 1100/1200
	 LABEQUIP
	  	1	  	Planetary Ball Mill PM 200
	 LABEQUIP
	  	1	  	In-Cell Western Key
	 LABEQUIP
	  	1	  	Criterion Cell plus Frt
	 LABEQUIP
	  	1	  	Sonicator Microplate Pkg 110V & Frt
	 LABEQUIP
	  	1	  	Criterion Cell
	 LABEQUIP
	  	1	  	Biotek ELX 405UCWVS Microplate Washer
	 LABEQUIP
	  	1	  	Biotek ELX 405UCWVS Microplate Washer
	 LABEQUIP
	  	1	  	RV 10 digital with dry ice cond-c, 115V
	 LABEQUIP
	  	1	  	MVP 10 basic vaccum pump, 115V
	 LABEQUIP
	  	1	  	CO2 Incubator 33FT3 70C115V60H
	 LABEQUIP
	  	1	  	Thermo Fisher—Barnstead Lab-Line

					
	 LABEQUIP
	  	1	  	Biacore: BC S200 Processing Unit-Silver
	 LABEQUIP
	  	1	  	BC S200 Processing Unit-S&H Charge
	 LABEQUIP
	  	1	  	BC S200: 19244701 Main Cable 115V
	 LABEQUIP
	  	1	  	BC S200: 181177333 Computer SFF
	 LABEQUIP
	  	1	  	BC S200: 29153626 Monitor, Widescreen
	 LABEQUIP
	  	1	  	BC S200: 28402072 Keyboard
	 LABEQUIP
	  	1	  	BC S200: Biacore S200-Inside Del Lvl II
	 LABEQUIP
	  	1	  	lnnova U725 220V/60Hz Freezer, 25.6 Ft
	 LABEQUIP
	  	1	  	LCMS-2020 Detector with Advanced
	 LABEQUIP
	  	1	  	LCMS-2020 Detector with Advanced
	 LABEQUIP
	  	1	  	LCMS-2020: FCV-34AH 6-position, 7 port
	 LABEQUIP
	  	1	  	LCMS-2020: Valve Installation Kit
	 LABEQUIP
	  	1	  	LCMS-2020: FCV piping assy-addtl piping
	 LABEQUIP
	  	1	  	LCMS-2020: FCV piping assy
	 LABEQUIP
	  	1	  	LCMS2020: Fast Flow Cell, i-Series 3D
	 LABEQUIP
	  	1	  	LCMS-2020 Detector w/ Advanced Data
	 LABEQUIP
	  	1	  	Biacore S200 24-Month Ext Warranty
	 LABEQUIP
	  	1	  	Trans-blot Turbo Transfer system-1704150
	 LABEQUIP
	  	1	  	Trans-Blot Turbo Cassette-1704151
	 LABEQUIP
	  	1	  	Part of Trans-Blot Turbo Transfer System
	 LABEQUIP
	  	1	  	Part of Trans-Blot Turbo Transfer System
	 LABEQUIP
	  	1	  	CombiFlash Rf Torrent Module UV
	 LABEQUIP
	  	1	  	CombiFlash Rf Torrent Module—Foxy
	 LABEQUIP
	  	1	  	CombitFlash Rf Torrent Module—Rack
	 LABEQUIP
	  	1	  	CombiFlash Rf Torrent Module—Solid
	 LABEQUIP
	  	1	  	CombiFlash Rf Torrent Module—Chrom
	 LABEQUIP
	  	1	  	Lamp, 1100/1200 DAD/MWD
	 LABEQUIP
	  	1	  	96 Multichannel Enhanced Tip Selection
	 LABEQUIP
	  	1	  	Beckman Coulter Biomek NXp
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook

					
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Epson Powerlite 1261Projector
	 OFFEQUIP
	  	1	  	LAN Infrastructure—lnv#s:130808AV005-
	 OFFEQUIP
	  	1	  	PolyCom—Clear One Max EX Wired
	 OFFEQUIP
	  	1	  	RCA 1-Handset 4-Line Cordless Telephone
	 OFFEQUIP
	  	1	  	Security System
	 OFFEQUIP
	  	1	  	Uninterrupted Power Supply System
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptops-HP EliteBook
	 OFFEQUIP
	  	1	  	Laptop Thinkpad
	 OFFEQUIP
	  	1	  	(2) Laptop EliteBook
	 OFFEQUIP
	  	1	  	Apple MacBook AIR (Rob)
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	HP Elitebook and Dock
	 OFFEQUIP
	  	1	  	Cisco Aironet
	 OFFEQUIP
	  	1	  	SonicWALL TZ300 Total Secure Security
	 OFFEQUIP
	  	1	  	SonicWALL TZ300 Total Secure Security
	 OFFEQUIP
	  	1	  	Meraki Legacy
	 OFFEQUIP
	  	1	  	Meraki Legacy
	 OFFEQUIP
	  	1	  	Meraki Legacy
	 OFFEQUIP
	  	1	  	Meraki Legacy
	 OFFEQUIP
	  	1	  	Cisco Ethernet
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	AED Battery
	 OFFEQUIP
	  	1	  	AED Battery
	 OFFEQUIP
	  	1	  	Surface Pro 3
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard

					
	 OFFEQUIP
	  	1	  	Surface Pro 4 w/dock & keyboard
	 OFFEQUIP
	  	1	  	Surface Pro 4, dock, Office & cover
	 OFFEQUIP
	  	1	  	Surface Pro 4, dock, Office & cover
	 OFFEQUIP
	  	1	  	Apple Macbook Pro (Steve)
	 OFFEQUIP
	  	1	  	Epson EX7240 Pro WXGA 3LCD Projector
	 OFFEQUIP
	  	1	  	Cisco Catalyst 48 Port Ethernet Switch
	 OFFEQUIP
	  	1	  	Monitor (Alexey)
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	Epson EX7240 Pro WXGA 3LCD Projector
	 OFFEQUIP
	  	1	  	Dell PowerEdge R530 Server & setup
	 OFFEQUIP
	  	1	  	Cisco Catalyst 2960X
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP Zbook workstation
	 OFFEQUIP
	  	1	  	HP ZBook 15u G3 Mobile Workstation,
	 OFFEQUIP
	  	1	  	HP ZBook 15 u Ge Workstation,
	 OFFEQUIP
	  	1	  	HP ZBook 15u G3 Mobile Workstation,
	 OFFEQUIP
	  	1	  	HP ZBook 15u G3 Mobile Workstation,
	 OFFEQUIP
	  	1	  	HP ZBook 15u G3 Mobile Workstation,
	 OFFEQUIP
	  	1	  	HP Zbook 15u G3 Mobile Workstation
	 OFFEQUIP
	  	1	  	HP Zbook 15u G3 Mobile Workstation
	 CAPSFTWRE
	  	1	  	Microsoft Great Plains Dynamics 2015
	 CAPSFTWRE
	  	1	  	(3) Windows Server 2012R2 Standard
	 CAPSFTWRE
	  	1	  	Dynamics GP Prof User License
	 CAPSFTWRE
	  	1	  	Certara SYBX006: Sybyl-X Suite
	 CAPSFTWRE
	  	1	  	eOne SmartlistBuilder, SmartView, and
	 LABEQUIP
	  	1	  	Vacuum Pump V-300 #11V300100 & warranty
	 LABEQUIP
	  	1	  	Image Xpress Micro XL High Content screening system w/software & licenses
	 LABEQUIP
	  	1	  	Tube gaurd, APC Smart-UPS RM, Reolink IP, Kenuco CAT 6 ethernet cable
	 LABEQUIP
	  	1	  	IncuCyte S3 HD/2CLR System package w/ software
	 LABEQUIP
	  	1	  	Tube gaurd, APC Smart-UPS RM, Reolink IP, Kenuco CAT 6 ethernet cable
	 LABEQUIP
	  	1	  	OLP WIN SVR CORE 2016-OB WIN RMT DT
	 LABEQUIP
	  	1	  	DELL NX3230
	 LABEQUIP
	  	1	  	DELL R740
	 LABEQUIP
	  	1	  	ION Automated Robotic arm for HCIS

 SCHEDULE C 

CHEMICALS AND Hazardous MATERIALS 
 List of
Chemicals and Hazardous Materials Anticipated to be used in the Arvinas Research Facility at 5 Science Park, New Haven, CT 
 The list below constitutes
an initial estimate of the chemicals and classes that may be utilized as the facility is populated. 
 Inorganic Compounds 

Sodium chloride 
 Silicon dioxide 

Magnesium sulphate 
 Sodium Sulphate 

Diatomaceous earth 
 Calcium chloride 

Ammonium chloride 
 Potassium iodide 

Nitrogen gas 
 Argon gas 

Solvents 
 Acetone 

Ethyl acetate 
 Hexane Acetonitrile 

Methanol 
 Ethanol 

Dichloromethane 
 Toluene 

Ethyl ether 
 Methyl sulphoxide 

Tetrahydrofuran 
 Acids 

Acetic acid 
 Citric acid 

Formic acid 
 Trifluoracetic acid Methanesulphonic acid 

Hydrochloric acid 
 Sulphuric acid 

Nitric acid 
 Tartaric acid 

Bases 
 Sodium bicarbonate 

Sodium carbonate 
 Potassium carbonate Sodium hydroxide 

Sodium hydride 
 Cesium carbonate Butyl lithium 

 Lithium hydroxide Ammonium hydroxide 

Triethylamine Diisopropylethylamine 
 Organic Compounds

 Pyrimidines 
 Aminopyridines 

Thiophenes 
 Thiazoles 

Pyrazoles 
 Furans 

Imidazotriazines 
 Pyrrolopyridines 

Furopyridines 
 Indoles 

Indazoles 
 Polyethylene glycols Carboxylates, alkyl/aryl Amides,
alkyl/aryl Sulphonamides, alkyl/aryl 
 Sulphones, alkyl/aryl Sulphoxides, alkyl/aryl Ethers, alkyl/aryl Alcohols, alkyl/aryl 

Carboxylates, alkyl/aryl Amines, alkyl/aryl 
 Sulphides,
alkyl/aryl Mercaptans, alkyl/aryl Ketones, alkyl/aryl 
 Halides, alkyl/aryl 

Aldehydes, alkyl/aryl 
 Chloroformates, alkyl/aryl 

Ureas, alkyl/aryl Stannanes, alkyl/aryl 
 Boronates, alkyl/aryl

 Tetrakis(triphenylphosphine)palladium(O)(l, I 1-Bis(diphenylphosphino)ferrocene)palladium(II)
dichloride 

 SCHEDULE D 

RULES AND REGULATIONS 
 1.
No sign, signal, advertisement, notice or other lettering, except as allowed in the Lease, shall be exhibited, inscribed, painted or affixed by any tenant on any part of the outside of the Leased Premises or inside of the Building without the prior
written consent of Landlord. No signs, advertisements or notices shall be painted or affixed on or to any windows or doors, or other parts of the Building, except of color, size and style and in such places as shall be first approved in writing by
Landlord. Interior signs on doors and directory tablet shall be inscribed, painted or affixed by each tenant at Tenant’s expense and shall be of a size, color and style acceptable to Landlord. Tenant agrees that any door or directory signage
shall be removed at the end of the Lease Term and all doors and walls will be restored to their original conditions. All signs that are contracted for by Landlord will be at the rate fixed by Landlord from time to time and Tenant will be billed and
will pay for such service accordingly. 
 2. Tenant will refer to Landlord all contractors, contractors’ representatives and
installation technicians rendering any service to Tenant for Landlord’s supervision, approval and control before performance of any contractual service. Except for the hanging of pictures, no boring, cutting or stringing of wires shall be
permitted, except with the prior written consent of Landlord and as Landlord may direct. This provision shall apply to all work performed in the Building including installations of telephones, telegraph equipment, electrical devices and attachments
and installations of any nature affecting floors, walls, woodwork, trim, windows, ceilings, equipment or any other physical portion of the Building. 

3. The Landlord shall designate appropriate entrances for the moving to or from the Building, of equipment, materials, supplies, furniture or
other property, and Tenant shall not use any other entrances or elevators for such purposes, except as designated by Landlord. Movement in or out of the Building of furniture or office equipment or dispatch or receipt by Tenant of any merchandise or
materials which require use of elevators or stairways or movement through Building entrances or lobby shall be restricted to hours designated by Landlord. All such movement shall be under the supervision of Landlord and in the manner agreed between
Tenant and Landlord by arrangement before performance. Such pre-arrangement initiated by Tenant will include determination by Landlord and subject to its decision and control as to the time, method and routing
of movement and as to limitations imposed for safety or other concerns which may prohibit any article, equipment or any other item from being brought into the Building. Tenant is to assume all risk as to damage to articles moved and injury to
persons or public engaged or not engaged in such movement, including equipment, property and personnel of Landlord, if damaged or injured as a result of acts in connection with carrying out this service for Tenant from the time of entering the
Property to completion of work. 
 Landlord shall not be liable for the acts of any person engaged in, or any damage or loss to, any of said
property or persons resulting from any act in connection with such service performed for Tenant, unless performed by Landlord, its agents, employees or contractors. 

4. Tenant shall not deface any part of the Leased Premises, Building or Property. 

 5. No portion of the Leased Premises or of any other part of the Building shall at any time be
used for cooking (except in designated areas), or occupied for lodging or sleeping, or for any immoral or illegal purpose, or for any purpose that will damage the Property or the reputation thereof or for any purpose other than that specified in the
Lease covering the Leased Premises. 
 6. Tenant shall not place, install or operate on the Leased Premises or in any other part of the
Building or on the grounds any engine or machinery or maintain, use or keep any flammable, explosive or hazardous material without the prior written consent of Landlord. 

7. Landlord will not be responsible for lost or stolen personal property, equipment, money or jewelry from Tenant’s area or public rooms
regardless of whether or not such loss occurs when the area is locked against entry. 
 8. No birds or animals shall be brought into or kept
in or about the Building, without permission of Landlord, except as necessary for Tenant’s conduct of business on the Leased Premises. Tenant shall at its sole expense comply with all federal, state and local laws, ordinances, codes and
regulations applicable to the presence of such birds or animals on the Leased Premises. 
 9. Tenants shall not hire or employ employees of
Landlord without Landlord’s prior express written consent. Tenants shall not give gifts of money or property to employees of Science Park or its agents. 

10. Landlord will not permit entrance to the Leased Premises by use of pass keys controlled by Landlord to any person at any time without
written permission by Tenant, except to employees, contractors or service personnel directly supervised by Landlord. 
 11. The entries,
passages, doorways, elevators, elevator doors, hallways and stairwells shall not be blocked or obstructed; no rubbish, litter, trash or material of any nature shall be placed, emptied or thrown in these areas; and such areas shall not be used at any
time except for ingress or egress by Tenant, Tenant’s agents, employees, invitees, Tenant’s equipment, furnishings and supplies to or from the Leased Premises. 

12. Tenant shall not do or permit anything to be done in or about the Building or bring or keep anything therein that will in any way increase
the rate of fire or other insurance on the Building or on property kept therein, or obstruct or interfere with the rights of, or otherwise injure or annoy other tenants or do anything in conflict with the valid pertinent laws, rules or regulations
of any government authority. 
 13. Landlord desires to maintain the highest standards of environmental comfort and convenience for the
tenancy. It will be appreciated if any undesirable conditions or lacks of courtesy or attention are reported directly to Landlord. 
 14.
Intentionally Omitted. 

 15. Landlord shall have the right to determine and prescribe the weight and proper position of
any unusually heavy equipment including safes, large files, etc. that are to be placed in the Building, and only those which in the opinion of Landlord do not exceed acceptable floor loading and might not with reasonable probability do damage to the
floors, structure and/or freight elevator, may be moved into said Building. Landlord’s permission will not be unreasonably withheld. Any damage occasioned in connection with the moving or installing of such aforementioned articles in said
Building or the existence of same in said Building shall be paid for by Tenant, unless otherwise covered by insurance. 
 16. Landlord shall
have the right to prohibit the use of the Science Park Development Corporation name, or of the name of the Science Park project or of any Science Park building, or any other publicity by Tenant, which, in Landlord’s opinion, tends to impair
Landlord’s Reputation or that of the Building or its desirability for the executive offices of Landlord or of other tenants; and, upon written notice from Landlord, Tenant will refrain from or discontinue such use or publicity. Landlord’s
permission will not be unreasonably withheld. 
 17. No food or beverages may be stored in any areas other than in those specifically
designated for such purposes. Also, waste materials, including trash from the packaging, preparation or serving of the above, must be disposed of the same day in the proper receptacles. Tenant must bear the cost of correcting any pest problem
resulting from these activities. 
 18. No weapons are allowed on the Property or on the real property known as “Science Park” of
which the Property forms a part. 
 19. Any device used for moving of furniture, freight, mail or paper goods that will be used on a daily
basis will be padded in such a way as to protect from possible damage any surface with which it may come in contact. Any device used on an occasional basis, which is not padded, will be operated in a safe manner so as to prevent damage to any walls,
doors, floors, ceilings or other surfaces. Hand trucks must have rubber tires. 
 20. All work done by service personnel, whether in-house or contracted, shall be done in a first class manner to accepted standards of the trade and shall conform to all codes imposed by any governmental authority. 

21. No awnings or other projections shall be attached to the outside walls of the Building without the prior written consent of Landlord. No
curtains, shades or screens shall be attached to, or hung in or used in connection with any window or door of the Leased Premises without the prior written consent of Landlord. Such awnings, projections, curtains, blinds, shades, screens or other
fixtures so permitted by Landlord must be of a quality, type, design and color and attached in the manner approved by Landlord. 
 22. No
show cases or other articles shall be placed in front of or affixed to any part of the exterior of the Building, nor placed in the halls, corridors or vestibules without the prior written consent of Landlord. 

 23. Water and wash closets and other plumbing fixtures shall not be used for any purpose other
than those for which they were constructed and no sweepings, rubbish, rags or other substances shall be thrown therein. All damages resulting from any misuse of the fixtures shall be borne by any Tenant who, or whose servants, employees, agents,
contractors, subcontractors, licensees or visitors, shall have caused the same. 
 24. Landlord reserves the right to exclude from the
Building any persons who do not present identification acceptable to Landlord. Landlord shall in no case be liable for damages for any error with regard to admission or exclusion from the Building of any person. 

In the case of riot, mob, invasion, public excitement or other circumstances rendering such actions advisable in Landlord’s opinion,
Landlord reserves the right to prevent access to the Building during the continuance of the same by such actions as the Landlord may deem appropriate including closing doors. 

25. The requirements of Tenant will be attended to only upon application at the office of Landlord’s building manager in the manner set
forth by Landlord. Landlord’s employees shall not perform any work or do anything outside of their regular duties unless under special instructions from Landlord. 

26. Canvassing, soliciting and peddling in the Building is prohibited and Tenant shall cooperate to prevent same. 

27. Intentionally Omitted. 
 28.
Hours of Operation 
 Science Park is open 24- hours a day, 7 days a week. The normal hours of
operation are Monday through Friday from 8:00 a.m. to 6:00 p.m. excluding holidays. 
 29. Keys to Offices 

Two keys will be issued for each tenant’s space. The principal of the Tenant will sign for the keys upon issuance. The Tenant may make
additional copies of the keys as needed. It will be the responsibility of the Tenant’s principal to keep track of those persons to whom he has issued keys. All keys and photo IDs must be returned to the Landlord upon termination of the Lease or
a $15 penalty per item charge will be deducted from the security deposit held by Landlord. Replacement of locks because of lost or unreturned keys shall be undertaken at the Tenant’s expense. 

30. Parking and Speed Limit 

All Science Park companies and employees will be assigned to specific parking lot areas. There are no assigned spaces other than for
handicapped parking. It is requested that individuals park between the painted lines. If for business reasons you wish to leave your vehicle overnight or for the weekend, the security officer must be notified. No one is allowed to
“deadhead” his or her vehicle in the parking lots. Vehicles found improperly parked obstructing exits, fire lanes, other spaces, etc. will be towed at the owner’s expense. 

 The speed limit for the private drives and roadways within Science Park is 15 m.p.h.
Please obey this speed limit for the safety of everyone walking and driving within the Park. 
 31. Reporting Emergencies or
Incidents 
 All emergencies (fire, injury, illness, etc.) should be reported to security immediately at
                . This telephone number must only be used in cases of emergency. Incidents such as thefts, unwanted persons, vandalism or damage to parked vehicles in
Science Park should also be reported as soon as possible. 
 32. Film Crews. Tenant shall provide Landlord with at least 24 hours
advance written notice of any scheduled visits to and/or work within, on or about Science Park by any film crew, whether in connection with a documentary or dramatic production, interviews, research, promotion, advertising, news coverage or
otherwise. 
 33. Special Events Held by Science Park Companies 

Any event held by a Science Park company which may disturb or interfere with the security, safety or operations of other companies or which
involves more than ten (10) people entering into the Park must be registered with the Landlord and the Landlord’s security site supervisor. The host company may be required to hire additional security or maintenance personnel. For any such
special event, the following will be required: 
 (a) Events will be held within the confines of the host company’s Leased Premises and
only within an SPDC common area when express permission has been granted. 
 (b) Participants will be restricted to a pre-determined area near which bathroom facilities are available. 
 (c) A guest list must be provided to
Landlord’s security site supervisor at least twenty four (24) hours in advance of the special event. 
 (d) Arrangements will be
made for ample parking to be available with proper signs provided to guide and inform the guests. The host company should be prepared to provide the signs. 

(e) Alcohol consumption must be monitored by the host company for underage persons and for excessive consumption by guests. 

(f) The host company will be responsible for cleanup and for any damage and costs incurred in restoring any area involved to its original good
condition. 

 34. Roof Off Limits. No Tenant and no employee or invitee of any Tenant or employee, shall
go upon the roof of the Building without Landlord’s permission. 
 35. Changes to Entrances. Landlord shall have the right at any
time without incurring any liability to Tenant to change the arrangement and/or location of entrances or passageways, doors or doorways, corridors, elevators, stairs, toilets or other common areas of the Building. 

36. Tenant Information. 

(a) Tenants are required to provide a 2-3 line description of their company’s operation. This
description will include P.O. Box (if applicable), telephone numbers (fax, voice, e-mail) and company principal(s). 

(b) Each year as of June 30th, SPDC conducts a survey of employment in Science Park
companies which includes questions pertaining to personnel and strategic data which identifies benchmarks for Science Park performance, including but not limited to the number of employees and other such data, education levels, company expansion
plans, and needs, etc. This data is necessary for SPDC’s reporting to its lenders and others. Individual company data is kept confidential. Tenants including Ground lease Tenants/Subtenants are required to participate in this survey. In
addition, Tenant shall promptly distribute SPDC’s current survey form to their subtenant companies, follow up, and collect the completed forms from subtenants by the established due date. 

37. Yale University Amenities 

Commercial (those having no off street or public customers) Tenants of Science Park and their employees are invited to take advantage of the
following current amenities at Yale University. All Yale amenities are offered at the sole discretion of Yale University and the following language cannot be changed without the express approval of Yale. 

A. Payne Whitney Gymnasium 
  

	 	1.	 Fitness Center – cardio machines, Cybex circuits, free weights 

 

	 	2.	 Swimming Pools—lap swimming 

 

	 	3.	 Lanman Center/Greenberg Brothers Track – basketball, jogging 

 

	 	4.	 15 International Squash Courts – recreational squash 

 

	 	5.	 Physical Education Classes including aerobics, dance, martial arts, sports skills 

 

	 	6.	 Sauna for Women, Sauna for Men – for health/relaxation 

Membership to Payne Whitney Gym: 

 The membership fee is the same as charged to Yale faculty and staff. To obtain a membership
simply present a letter at the membership office in the Payne Whitney Gym on your company’s letterhead which states that you are an employee of a Science Park company. After paying the fee, you will receive a membership card, which must be
presented for admission to the facilities. 
 The Membership Office is open Monday through Friday 10:00 a.m. to 2:00 p.m. and 3:15 p.m. to
6:00 p.m. Please call the membership office at (203) 432-2497 for additional information. 
 B. Yale Golf Course
Access 
 1. Corporate Membership: (For corporations and businesses that will elect for membership, four individuals within the
corporation or business.) the four individuals will be entitled to unlimited play. (Alternatively, the corporation/business can elect to purchase 300 rounds, within the calendar year, for use by its employees and guests.) The one time initiation fee
will be waived. Contact the Membership Office at (203) 392-2306 for cost of membership and details. 

2. Involvement with Yale Golf Classic and other golf events. Contact Barbara Chesler at
                     for details. 
 C. Yale Football
Corporate Hospitality and Group Outings 
 For information on adult or youth group outings for football or other varsity athletic events
contact Pat O’Neill at                     . 
 D.
Yale University Library Privileges 
 Employees of Science Park tenant companies when SPDC has a current, valid lease on file may
request a Yale Library Card, which will be issued at no charge. The request must be made using the SPDC designed standard, bearer letter on SPDC (or in the case of an SPDC ground leasee Tenant, the ground leasee Tenant’s letterhead),
counter-signed by the sub-tenant company’s designated Yale Privileges Representative. When leases commence or terminate, SPDC or SPDC’s ground leasee Tenants will update their list of valid leasees
and email the list to the Yale Sterling Memorial Library’s circulation desk. The Circulation Desk will compare each library card request letter to the companies on the lists to confirm privileges. A card valid for 1 year will be available for
pickup at the Library approximately one week after the request is received. If you have any questions regarding this validation procedure only, contact SPDC; Clio Nicolakis, at
                    . For all other questions, contact the Sterling Memorial Library at 203.432.1853 or smlcirc@yale.edu. 

 FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (the “Agreement”) is entered into as of this 23rd day of May, 2018 (the “Effective Date”) by and between SCIENCE PARK DEVELOPMENT CORPORATION, a Connecticut non stock corporation having its office at 5 Science Park, New
Haven, Connecticut 06511 (the “Landlord”), and ARVINAS, INC., a Delaware corporation having a principal place of business at 5 Science Park, 3rd Floor, New Haven,
Connecticut 06511 (the “Tenant”) in modification of that certain Lease between the Landlord and the Tenant executed on or about January 2, 2018 (the “Lease”). 

WHEREAS, the Landlord and the Tenant are parties to the Lease which is in full force and effect; and 

WHEREAS, the Landlord and the Tenant wish to modify the Lease as more fully set forth herein; and 

NOW, THEREFORE, the Landlord and the Tenant agrees as follows: 

1. Amendments to Lease. As of the Effective Date, the following modifications are made to the Lease: 

a) Section 1.1(a) of the Lease is amended and restated to read, in full, as follows: 

(a) Landlord is the owner of the real property located at Science Park, New Haven, Connecticut as described on Exhibit A
attached hereto (the “Property”). The Tenant shall lease from Landlord the following premises located in Science Park Building 5 (“Building 5”), which is located on the Property: (i) approximately 7,873
rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-1 (the “First Floor Premises”); (ii) approximately 10,249 rentable square
feet on the second floor of Building 5, as shown on the floor plan attached hereto as Schedule A-2 (the “Second Floor Premises”); and approximately 9,456 rentable square feet on the
third floor of Building 5, as shown on the floor plan attached hereto as Schedule A-3 (the “Third Floor Premises”). Tenant shall have exclusive use of the First Floor Premises, the
Second Floor Premises, the Third Floor Premises and Landlord’s fixtures, equipment and personalty set forth in Schedule A-1 attached hereto (“Landlord’s Additional Property”).
In addition to the aforementioned First Floor Premises, Second Floor Premises and Third Floor Premises, the Tenant shall also lease from Landlord: as of May 15, 2018, approximately 2,632 rentable square feet on the first floor of Building 5, as
shown on the floor plan attached hereto as Schedule A-4 (the “Part A Space”), and, as of May 1, 2019, or earlier as provided in Section 2.4.G. hereof, approximately 3,705
rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-4 (the “Part B Space”). The First Floor Premises, the Second Floor
Premises, the Third Floor Premises, the Part A Space, the Part B Space, and the Landlord’s Additional Property shall be referred to herein collectively as the “Leased Premises.” Landlord’s Additional Property shall be considered
part of the Leased Premises but shall remain property of the Landlord. 

 b) Section 1.2 of the Lease is amended by replacing “seventy five (75) parking
space” with “one hundred (100) parking spaces”. 
 c) Section 2.3 of the Lease is amended by adding the following
paragraph to the end thereof to read in full as follows: 
 Landlord shall contribute rent abatements up to the total amount of SEVENTY FIVE
THOUSAND DOLLARS ($75,000.00) (“Part B Space Contribution”) on account of the cost of refurbishing the Leased Premises including design and engineering costs. Part B Space Contribution shall be available to Tenant only as follows:
(i) Tenant shall submit to Landlord a written request to utilize a portion of Part B Space Contribution as an abatement of one or more monthly installments of Base Rent (as hereinafter defined) (each a “Part B Space Contribution
Request”); (ii) each Part B Space Contribution Request shall include evidence reasonably satisfactory to Landlord that Tenant has actually paid to contractors and other relevant professionals an amount at least equal to the amount sought in
the Part B Space Contribution Request in connection with construction, design and or other service and materials directly related to and necessary in connection with renovation of the Leased Premises; (iii) unless a Part B Space Contribution
Request is disputed by Landlord within ten (10) days from receipt by Landlord, Tenant shall be entitled to abatement of the Base Rent monthly installment(s) first payable not less than thirty (30) days from submission of such Part B Space
Contribution Request to Landlord; (iv) the Part B Space Contribution shall not be available to Tenant for reimbursement before May 1, 2019; and (v) notwithstanding sub-section (iv) hereof,
Tenant may use and be reimbursed now for a small amount of the Part B Space Contribution to repair the floor in the Part A Space, and, subject to and without interfering with Landlord’s rights described in Section 2.4.G.(i) of this Lease,
Tenant may immediately commence any other work in the Leased Premises, to be reimbursed therefor on or after May 1, 2019. 
 d) Section
2.4 of the Lease is amended by adding the following new subparagraphs to read, in full, as follows: 
  

	 	F.	 As of May 15, 2018, Landlord shall tender to Tenant possession of the Part A Space in its then “as
is” condition and Tenant agrees to accept possession of such portion of the Leased Premises in its then “as is” condition. 

  

	 	G.	 As of May 15, 2018, Landlord shall tender to Tenant possession of the Part B Space in its then “as
is” condition and Tenant agrees to accept possession of such portion of the Leased Premises in its then “as is” condition, subject to the following: 

  
 2 

	 	(i)	 through August 31, 2018, Landlord shall retain access to and the use of approximately 1,500 square feet of
the Part B Space for storage, assembly of cubicles and furniture and such other uses as Landlord may require. 

 e) Section
3.1.A. of the Lease is amended and restated to read, in full, as follows: 
 A. As used herein, the term “Lease Year” shall mean the 12-month period commencing on the Commencement Date and each succeeding 12-month period. 

During the initial Term, Tenant shall pay to Landlord a base rent (“Base Rent”) for each Lease Year as follows: 

 

													
	 Months of Term
	  	Base Rent Rate
(Annually per RSF)	 	  	Applicable
RSF	 	  	Monthly Base Rent	 
	 January, 2018
	  	$	21.00	 	  	 	19,705	 	  	$	34,483.75	 
	 February, 2018 – May 14, 2018
	  	$	21.00	 	  	 	27,578	 	  	$	48,261.50	 
	 May 15 – 31, 2018
	  	$	21.00	 	  	 	30,210	 	  	$	52,867.50	 
	 June, 2018 – July, 2018
	  	$	21.00	 	  	 	22,337	 	  	$	39,089.75	 
	 August, 2018 – April, 2019
	  	$	21.00	 	  	 	30,210	 	  	$	52,867.50	 
	 May, 2019 – December, 2022
	  	$	21.00	 	  	 	33,915	 	  	$	59,351.25	 

 f) Section 3.4 of the Lease is amended and restated to read, in full, as follows:  

3.4. Electricity. Tenant shall pay to Landlord, as Additional Rent hereunder, an amount equal to $1.62 per year for each
rentable square foot of the Leased Premises, which shall be payable in equal monthly installments together with the regular monthly payments of Base Rent and Additional Rent. For the purposes of this paragraph: (a) the Leased Premises shall be
deemed to constitute 33,915 rentable square feet as of May 15, 2018 and continuing for the balance of the Term; and (b) the annual charge for electricity shall be $54,942.30 payable in monthly installments of $4,578.53. 

g) Section 24.1 of the Lease is amended by changing the amount of the Deposit to $15,760.00. 

2. Schedules. Schedule A-4 and Schedule A-5 attached
hereto are hereby made a part of the Lease as amended by this Agreement. Schedule A-1 to the Lease is deleted and Schedule A-1 attached to this Agreement is substituted
therefor and is hereby made a part of the Lease. 

  
 3 

 3. Reaffirmation of Lease. In all other respects, the Lease, as hereby amended, is
reaffirmed by the Parties and shall be and remain in full force and effect. 
 4. Landlord and Tenant Remain Obligated. Nothing herein
shall constitute a waiver or release by the Landlord or the Tenant of any unperformed obligations of the other under the Lease as modified by this Agreement. 

5. Brokerage. Landlord shall pay an agreed commission to Colliers International by way of a separate agreement. Landlord represents to
Tenant that no other broker has any right to lease space at the Property and Landlord agrees to indemnify and hold Tenant harmless from and against the claims, losses, damages, costs and expenses (including, but not limited to, reasonable
attorneys’ fees) incurred by Tenant as a result of any party asserting a right to a fee or commission claiming to have acted by, under, through or on behalf of the Landlord. Tenant agrees to indemnify and hold Landlord harmless from and against
the claims, losses, damages, costs and expenses (including, but not limited to, reasonable attorneys’ fees) incurred by Landlord as a result of any party other than Colliers International claiming a fee or commission by, under or through Tenant
on account of this Agreement and/or the extension of the Term of the Lease provided for in this Agreement. 
 6. Later Provision Controls.
In case of any inconsistency between the provisions of the Lease and this Agreement, the provisions of this Agreement shall govern and control. Without limiting the meaning or application of the foregoing sentence in any manner, the provisions
of Paragraph 6 of this Agreement supersede and replace Article 29 with respect to this Agreement. 
 7. Capitalized Terms. Capitalized
terms used but not otherwise defined herein shall have the same meaning as set forth in the Lease. 
 8. Entire Agreement. This
Agreement sets forth the entire agreement between the parties with respect to the matters set forth herein. There have been no additional oral or written representations or agreements. 

9. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. Signatures to this Agreement transmitted by telecopy or otherwise electronically shall be valid and effective to bind the party so signing. Each party agrees promptly to deliver an
execution original to this Agreement with its actual signature to the other party, but a failure to do so shall not affect the enforceability of this Agreement, it being expressly agreed that each party to this Agreement shall be bound by its own
telecopied or electronic signature and shall accept the telecopied or electronic signature of the other party to this Agreement. 
 [The
Signature Page(s) Follow.] 

  
 4 

 Dated as of the date and year first above written. 

 

			
	TENANT:
	ARVINAS, INC.
		
	By:	 	 /s/ Sean Cassidy

		 	Sean Cassidy
		 	Treasurer and Chief Financial Officer
	
	LANDLORD:
	SCIENCE PARK DEVELOPMENT CORPORATION
		
	By:	 	 /s/ Clio Nicolakis

		 	Clio Nicolakis
		 	Executive Director and Controller

  

					
	STATE OF CONNECTICUT	  	)	  	
		  	) ss.: New Haven	  	May 23, 2018
	COUNTY OF New Haven 	  	)	  	

 On this date personally appeared before me, Sean Cassidy, who acknowledged himself to be the duly authorized
Treasurer and Chief Financial Officer of Arvinas, Inc., a Delaware corporation, and that the execution hereof was the free act and deed of such corporation and his/her free act and deed as such officer. 

IN WITNESS WHEREOF, I hereunto set my hand. 

SKYLA ROSE WILSON 

			
	 NOTARY PUBLIC
	  	 /s/ Skyla Rose Wilson

	MY COMMISSION EXPIRES MAR. 31, 2023	  	Commissioner of the Superior Court/Notary Public

  

					
	STATE OF CONNECTICUT	 	)	  	
		 	) ss.: New Haven	  	May 16, 2018
	COUNTY OF NEW HAVEN	 	)	  	

 On this date personally appeared before me, Clio Nicolakis, who acknowledged herself to be the duly authorized
Executive Director and Controller of Science Park Development Corporation, a Connecticut non stock corporation, and that the execution hereof was the free act and deed of such corporation and her free act and deed as such officer. 

IN WITNESS WHEREOF, I hereunto set my hand. 
  

	
	 /s/ David Silvertone

	Commissioner of the Superior Court/Notary Public
	David Silvertone

  
 5 

 

 

 SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (the “Agreement”) is entered into as of this 4th day of September, 2018 (the
“Effective Date”) by and between SCIENCE PARK DEVELOPMENT CORPORATION, a Connecticut non stock corporation having its office at 5 Science Park, New Haven, Connecticut 06511 (the “Landlord”), and ARVINAS,
INC., a Delaware corporation having a principal place of business at 5 Science Park, 3rd Floor, New Haven, Connecticut 06511 (the “Tenant”) in modification of that certain
Lease between the Landlord and the Tenant executed on or about January 2, 2018, as amended by the First Amendment to Lease between landlord and Tenant and dated as of May 23, 2018 (the “First Amendment” and, collectively,
the “Lease”). 
 WHEREAS, the Landlord and the Tenant are parties to the Lease which is in full force and effect;
and 
 WHEREAS, the Landlord and the Tenant wish to modify the Lease as more fully set forth herein; and 

NOW, THEREFORE, the Landlord and the Tenant agrees as follows: 

1. Amendments to Lease. As of the Effective Date, the following modifications are made to the Lease: 

a) Section 1.1(a) of the Lease is amended and restated to read, in full, as follows: 

(a) Landlord is the owner of the real property located at Science Park, New Haven, Connecticut as described on Exhibit A
attached hereto (the “Property”). The Tenant shall lease from Landlord the following premises located in Science Park Building 5 (“Building 5”), which is located on the Property: (i) approximately 7,873
rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-1 (the “First Floor Premises”); (ii) approximately 10,249 rentable square feet on the second floor of
Building 5, as shown on the floor plan attached hereto as Schedule A-2 (the “Second Floor Premises”); and approximately 9,456 rentable square feet on the third floor of Building 5, as shown on the floor plan attached hereto
as Schedule A-3 (the “Third Floor Premises”). Tenant shall have exclusive use of the First Floor Premises, the Second Floor Premises, the Third Floor Premises and Landlord’s fixtures, equipment and personalty set forth
in Schedule A-1 attached hereto (“Landlord’s Additional Property”). In addition to the aforementioned First Floor Premises, Second Floor Premises and Third Floor Premises, the Tenant shall also lease from Landlord:
(I) as of May 15, 2018, approximately 2,632 rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-4 (the “Part A Space”); (II) as of May 1, 2019, or
earlier as provided in Section 2.4.G. hereof, approximately 3,705 rentable square feet on the first floor of Building 5, as shown on the floor plan attached hereto as Schedule A-4 (the “Part B Space”); and (III) as of
September 1, 2018, approximately 84 rentable square feet on the first floor of Building 5 as shown on the floor plan attached hereto as Schedule A-5 (the “September 2018 Space”). The First

 
Floor Premises, the Second Floor Premises, the Third Floor Premises, the Part A Space, the Part B Space, the September 2018 Space and the Landlord’s Additional Property shall be referred to
herein collectively as the “Leased Premises.” Landlord’s Additional Property shall be considered part of the Leased Premises but shall remain property of the Landlord. 

b) Section 2.4 of the Lease is amended by adding the following new subparagraphs to read, in full, as follows: 

 

	 	H.	 As of September 1, 2018, Landlord shall tender to Tenant possession of the September 2018 Space in its
then “as is” condition and Tenant agrees to accept possession of such portion of the Leased Premises in its then “as is” condition. 

c) A new Section 2.6.1 is added to the Lease to read in full as follows: 

2.6.2 September 2018 Premises. Landlord, at Tenant’s sole cost and expense, shall close off the door opening in the September
2018 Premises that provides access to an adjoining tenant’s premises. Landlord shall provide Tenant with a nonbinding estimate of the cost for such work and Tenant shall reimburse Landlord within 30 days of the completion of such work. 

d) Section 3.1.A. of the Lease is amended and restated to read, in full, as follows: 

A. As used herein, the term “Lease Year” shall mean the 12-month period commencing on the Commencement Date and each succeeding 12-month period. 

During the initial Term, Tenant shall pay to Landlord a base rent (“Base Rent”) for each Lease Year as follows: 

 

													
	 Months of Term
	  	Base Rent Rate
(Annually per RSF)	 	  	Applicable
RSF	 	  	Monthly Base Rent	 
	 January, 2018
	  	$	21.00	 	  	 	19,705	 	  	$	34,483.75	 
	 February, 2018 – May 14, 2018
	  	$	21.00	 	  	 	27,578	 	  	$	48,261.50	 
	 May 15 – 31, 2018
	  	$	21.00	 	  	 	30,210	 	  	$	52,867.50	 
	 June, 2018 – July, 2018
	  	$	21.00	 	  	 	22,337	 	  	$	39,089.75	 
	 August, 2018
	  	$	21.00	 	  	 	30,210	 	  	$	52,867.50	 
	 September 2018 – April, 2019
	  	$	21.00	 	  	 	30,294	 	  	$	53,014.50	 
	 May, 2019 – December, 2022
	  	$	21.00	 	  	 	33,999	 	  	$	59,498.25	 

  
 2 

 e) Section 3.4 of the Lease is amended and restated to read, in full, as follows: 

3.4. Electricity. Tenant shall pay to Landlord, as Additional Rent hereunder, an amount equal to $1.62 per year for each rentable
square foot of the Leased Premises, which shall be payable in equal monthly installments together with the regular monthly payments of Base Rent and Additional Rent. For the purposes of this paragraph: (a) the Leased Premises shall be deemed to
constitute 33,915 rentable square feet as of May 15, 2018 through August 31, 2018 and 33,999 rentable square feet as of September 1, 2018 and continuing for the balance of the Term; (b) for the period of May 15, 2018 through
August 31, 2018, the annual charge for electricity shall be $54,942.30 payable in monthly installments of $4,578.53; and (c) for the period of September, 2018 and continuing for the balance of the Term, the annual charge for electricity
shall be $55,078.38 payable in monthly installments of $4,589.87. 
 f) A new Article 37 is added to the Lease to read in full as follows:

 ARTICLE 37 REIMBURSEMENT OF LANDLORD COSTS 

Except as expressly provided otherwise in this Lease, Tenant shall reimburse Landlord for all of Landlord’s out of pocket costs
(including architectural, engineering and project management fees) incurred in evaluating Tenant’s proposed alterations to some or all of the September 2018 Space and monitoring approved construction work. Landlord shall provide notice to
Tenant as to when out of pocket costs, expenses or fees (including architectural, engineering and attorney’s fees) are likely to be incurred, together with a good faith (but nonbinding) estimate as to the amount of such costs, expenses or fees.
Tenant shall reimburse Landlord for all such out of pocket costs, expenses, or fees within thirty (30) days after receiving a request for reimbursement from Landlord together with a copy of any receipts or other record of such costs, provided,
however, that redactions to such invoices may be made by Landlord in its sole and absolute discretion. 
 2. Schedules. The reference
to Schedule A-5 in the First Amendment was in error and such reference is hereby deleted. Schedule A-5 attached hereto is hereby made a part of the Lease as amended by this Agreement. 

3. Reaffirmation of Lease. In all other respects, the Lease, as hereby amended, is reaffirmed by the Parties and shall be and remain in
full force and effect. 
 4. Landlord and Tenant Remain Obligated. Nothing herein shall constitute a waiver or release by the Landlord
or the Tenant of any unperformed obligations of the other under the Lease as modified by this Agreement. 

  
 3 

 5. Brokerage. Landlord shall pay an agreed commission to Colliers International by way of
a separate agreement. Landlord represents to Tenant that no other broker has any right to lease space at the Property and Landlord agrees to indemnify and hold Tenant harmless from and against the claims, losses, damages, costs and expenses
(including, but not limited to, reasonable attorneys’ fees) incurred by Tenant as a result of any party asserting a right to a fee or commission claiming to have acted by, under, through or on behalf of the Landlord. Tenant agrees to indemnify
and hold Landlord harmless from and against the claims, losses, damages, costs and expenses (including, but not limited to, reasonable attorneys’ fees) incurred by Landlord as a result of any party other than Colliers International claiming a
fee or commission by, under or through Tenant on account of this Agreement and/or the extension of the Term of the Lease provided for in this Agreement. 

6. Later Provision Controls. In case of any inconsistency between the provisions of the Lease and this Agreement, the provisions of this
Agreement shall govern and control. Without limiting the meaning or application of the foregoing sentence in any manner, the provisions of Paragraph 6 of this Agreement supersede and replace Article 29 with respect to this Agreement. 

7. Capitalized Terms. Capitalized terms used but not otherwise defined herein shall have the same meaning as set forth in the Lease.

 8. Entire Agreement. This Agreement sets forth the entire agreement between the parties with respect to the matters set forth
herein. There have been no additional oral or written representations or agreements. 
 9. Counterparts. This Agreement may be
executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Signatures to this Agreement transmitted by telecopy or otherwise electronically shall be valid
and effective to bind the party so signing. Each party agrees promptly to deliver an execution original to this Agreement with its actual signature to the other party, but a failure to do so shall not affect the enforceability of this
Agreement, it being expressly agreed that each party to this Agreement shall be bound by its own telecopied or electronic signature and shall accept the telecopied or electronic signature of the other party to this Agreement. 

[The Signature Page(s) Follow.] 

  
 4 

 Dated as of the date and year first above written. 

 

			
	 TENANT:
 ARVINAS,
INC.

		
	By:	 	/s/ Sean Cassidy
		 	Sean Cassidy
		 	Treasurer and Chief Financial Officer

  

			
	 LANDLORD:

SCIENCE PARK DEVELOPMENT CORPORATION

			
		
	By:	 	/s/ Clio Nicolakis
		 	 Clio Nicolakis

		 	 Executive Director and Controller

  

					
	STATE OF CONNECTICUT	  	)	  	
		  	) ss.: County of New Haven	  	September 4, 2018
	COUNTY OF New Haven 	  	)	  	

 On this date personally appeared before me, Sean Cassidy, who acknowledged himself to be the duly authorized
Treasurer and Chief Financial Officer of Arvinas, Inc., a Delaware corporation, and that the execution hereof was the free act and deed of such corporation and his/her free act and deed as such officer. 

IN WITNESS WHEREOF, I hereunto set my hand. 
  

			
		  	/s/ David Silvertone
		  	Commissioner of the Superior Court/Notary Public

  

					
	STATE OF CONNECTICUT	  	)	  	
		  	) ss.: New Haven	  	September 4, 2018
	COUNTY OF NEW HAVEN	  	)	  	

 On this date personally appeared before me, Clio Nicolakis, who acknowledged herself to be the duly authorized
Executive Director and Controller of Science Park Development Corporation, a Connecticut non stock corporation, and that the execution hereof was the free act and deed of such corporation and her free act and deed as such officer. 

IN WITNESS WHEREOF, I hereunto set my hand. 
  

			
		  	/s/ David Silvertone
		  	Commissioner of the Superior Court/Notary Public

  
 5

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