Document:

Form of Notice to Stockholders who are Record Holders

 Exhibit 4.3 
 [FORM OF NOTICE TO STOCKHOLDERS] 
 PRO-PHARMACEUTICALS, INC. 
 NOTICE TO STOCKHOLDERS WHO ARE RECORD HOLDERS 
 Up to [            ] Shares of Common Stock 
 Issuable Upon
Exercise of Rights to Subscribe for Such Shares at $[    ] per Two Shares 
 Enclosed for your consideration is a
prospectus, dated February [    ], 2009 (the “Prospectus”), relating to the offering by Pro-Pharmaceuticals, Inc. (the “Company”) of subscription rights (the “Rights Offering”)
to purchase shares of the Company’s common stock, par value $0.001 per share (“Common Stock”), by stockholders of record (“Record Date Stockholders”) as of 5:00 p.m., New York City time, on February
[    ], 2009 (the “Record Date”). 
 Pursuant to the offering, the Company is issuing Rights to
subscribe for up to [            ] shares of the Company’s Common Stock, on the terms and subject to the conditions described in the Prospectus. The Rights may be exercised at
any time during the subscription period, which commences on February [    ], 2009 and ends at 5:00 p.m., New York City time, on March [    ], 2009, unless extended by the Company in its sole discretion
(as it may be extended, the “Expiration Date”). The Common Stock is presently quoted on the OTC Bulletin Board under the symbol “PRWP.OB”. The Rights will not be listed for trading on any stock exchange or market or on the
OTC Bulletin Board. The Rights may not be sold, transferred or assigned, unless otherwise required by applicable law. 
 As described in the
Prospectus, Record Date Stockholders will receive one (1) Right for each share of Common Stock owned on the Record Date. 
 Each Right
entitles the holder (the “Rights Holders”) to purchase two shares of Common Stock at the subscription price of $[    ] per two shares (the “Basic Subscription Right”). 

 Rights Holders who fully exercise their Basic Subscription Rights will be entitled to subscribe for
additional shares that remain unsubscribed as a result of any unexercised Basic Subscription Rights (the “Over-Subscription Right” and together with the Basic Subscription Right, the “Rights”). Each
Over-Subscription Right entitles the holder to subscribe for an additional amount equal to up to 400% of the shares of Common Stock for which such holder was otherwise entitled to subscribe (calculated prior to the exercise of any rights). If
sufficient remaining shares of Common Stock are available, all over-subscription requests will be honored in full. If requests for shares of Common Stock pursuant to the Over-Subscription Right exceed the remaining shares of Common Stock available,
the remaining shares of Common Stock will be allocated pro-rata among Rights Holders who over-subscribe based on the number of Rights then held. Rights may only be exercised for two whole shares of Common Stock; no fractional shares of Common Stock
will be issued in the Rights Offering. 
 The rights will be evidenced by subscription rights certificates (the “Subscription
Certificates”). 
 Enclosed are copies of the following documents: 
  

	 	1.	Prospectus, dated February [    ], 2009; 

  

	 	2.	Subscription Certificate; and 

  

	 	3.	A return envelope, addressed to Continental Stock Transfer & Trust Company (the “Subscription Agent”). 

 Your prompt attention is requested. To exercise your Rights, you should properly complete and sign the Subscription Certificate and forward it, with
payment of the subscription price in full for each two whole shares of Common Stock subscribed for pursuant to the Basic Subscription Right and the Over-Subscription Right to the Subscription Agent, as indicated on the Subscription Certificate. The
Subscription Agent must receive the properly completed and duly executed Subscription Certificate and full payment at or prior to 5:00 p.m., New York City time, on the Expiration Date. 
 You will have no right to rescind your subscription after receipt of your payment of the subscription price, except as described in the Prospectus.
Rights not exercised at or prior to 5:00 p.m., New York City time, on the Expiration Date will expire. 
 ANY QUESTIONS OR REQUESTS
FOR ASSISTANCE CONCERNING THE RIGHTS OFFERING SHOULD BE DIRECTED TO MACKENZIE PARTNERS, INC., THE INFORMATION AGENT, TOLL-FREE AT THE FOLLOWING TELEPHONE NUMBER: (800) 322-2885.Form of Notice to Stockholders who are Acting as Nominees

 Exhibit 4.4 
 [FORM OF NOTICE TO STOCKHOLDERS ACTING AS NOMINEES] 
 PRO-PHARMACEUTICALS, INC. 
 NOTICE TO STOCKHOLDERS WHO ARE ACTING AS NOMINEES 
 Up to [            ] Shares of Common Stock 
 Issuable Upon Exercise of Rights to Subscribe for Such Shares at $[            ] per Two Shares 
 This letter is being distributed to broker-dealers, trust companies, banks and other nominees in connection with the offering by Pro-Pharmaceuticals, Inc. (the “Company”) of subscription rights (the
“Rights Offering”) to purchase shares of the Company’s common stock, par value $0.001 per share (“Common Stock”), by stockholders of record (“Record Date Stockholders”) as of 5:00 p.m., New
York City time, on February [    ], 2009 (the “Record Date”). 
 Pursuant to the offering, the Company
is issuing Rights to subscribe for up to [            ] shares of the Company’s Common Stock , on the terms and subject to the conditions described in the Prospectus. The Rights
may be exercised at any time during the subscription period, which commences on February [    ], 2009 and ends at 5:00 p.m., New York City time, on March [    ], 2009, unless extended by the Company in
its sole discretion (as it may be extended, the “Expiration Date”). The Common Stock is presently quoted on the OTC Bulletin Board under the symbol “PRWP.OB”. The Rights will not be listed for trading on any stock exchange
or market or on the OTC Bulletin Board. The Rights may not be sold, transferred or assigned, unless otherwise required by applicable law. 
 As described in the Prospectus, Record Date Stockholders will receive one (1) Right for each share of Common Stock owned on the Record Date. 
 Each Right entitles the holder (the “Rights Holders”) to purchase two shares of Common Stock at the subscription price of $[            ]
per two shares (the “Basic Subscription Right”). 

 Rights Holders who fully exercise their Basic Subscription Rights will be entitled to subscribe for
additional shares that remain unsubscribed as a result of any unexercised Basic Subscription Rights (the “Over-Subscription Right” and together with the Basic Subscription Right, the “Rights”). Each
Over-Subscription Right entitles the holder to subscribe for an additional amount equal to up to 400% of the shares of Common Stock for which such holder was otherwise entitled to subscribe (calculated prior to the exercise of any rights). If
sufficient remaining shares of Common Stock are available, all over-subscription requests will be honored in full. If requests for shares of Common Stock pursuant to the Over-Subscription Right exceed the remaining shares of Common Stock available,
the remaining shares of Common Stock will be allocated pro-rata among Rights Holders who over-subscribe based on the number of Rights then held. Rights may only be exercised for two whole shares of Common Stock; no fractional shares of Common Stock
will be issued in the Rights Offering. 
 The Rights are evidenced by a subscription rights certificate (a “Subscription
Certificate”) registered in your name or the name of your nominee. 
 We are asking persons who hold shares of the Company’s
Common Stock beneficially, and who have received the Rights distributable with respect to those shares through a broker-dealer, trust company, bank or other nominee, to contact the appropriate institution or nominee and request it to effect the
transactions for them. 
 If you exercise the Over-Subscription Right on behalf of beneficial owners of Rights, you will be required to
certify to the Subscription Agent and the Company, in connection with the exercise of the Over-Subscription Right, as to the aggregate number of Rights that have been exercised pursuant to the Subscription Right, whether the Rights exercised
pursuant to the Basic Subscription Right on behalf of each beneficial owner for which you are acting have been exercised in full and the number of shares of Common Stock being subscribed for pursuant to the Over-Subscription Right by each beneficial
owner of Rights on whose behalf you are acting. 
 Enclosed are copies of the following documents: 
  

	 	1.	Prospectus, dated February [    ], 2009; and 

  

	 	2.	A form of letter which may be sent to beneficial holders of the Company’s Common Stock. 

 Rights not exercised at or prior to 5:00 p.m., New York City time, on the Expiration Date will expire. 
 Additional copies of the enclosed materials may be obtained from the Information Agent, MacKenzie Partners, Inc., toll-free at the following
telephone number: (800) 322-2885. 
 NOTHING HEREIN OR IN THE ENCLOSED DOCUMENTS SHALL MAKE YOU OR ANY OTHER PERSON AN AGENT OF THE
COMPANY; THE DEALER-MANAGER, THE SUBSCRIPTION AGENT, THE INFORMATION AGENT OR ANY OTHER PERSON MAKING OR DEEMED TO BE MAKING OFFERS OF THE SECURITIES ISSUABLE UPON VALID EXERCISE OF THE RIGHTS, OR AUTHORIZE YOU OR ANY OTHER PERSON TO MAKE ANY
STATEMENTS ON BEHALF OF ANY OF THEM WITH RESPECT TO THE OFFERING, EXCEPT FOR STATEMENTS MADE IN THE PROSPECTUS.Form of Notice to Clients of Stockholders who are Acting as Nominees

 Exhibit 4.5 
 [FORM OF NOTICE TO BENEFICIAL STOCKHOLDERS OF COMMON STOCK] 
 PRO-PHARMACEUTICALS, INC.

 NOTICE TO CLIENTS OF STOCKHOLDERS WHO ARE ACTING AS NOMINEES 
 Up to [            ] Shares of Common Stock 
 Issuable Upon Exercise of Rights to Subscribe for Such Shares at $[            ] per Two Shares 
 Enclosed for your consideration is a prospectus, dated February [    ], 2009 (the “Prospectus”), relating to the
offering by Pro-Pharmaceuticals, Inc. (the “Company”) of subscription rights (the “Rights Offering”) to purchase shares of the Company’s common stock, par value $0.001 per share (“Common
Stock”), by stockholders of record (“Record Date Stockholders”) as of 5:00 p.m., New York City time, on February [    ], 2009 (the “Record Date”). 
 Pursuant to the offering, the Company is issuing Rights to subscribe for up to
[            ] shares of the Company’s Common Stock, on the terms and subject to the conditions described in the Prospectus. The Rights may be exercised at any time during the
subscription period, which commences on February [    ], 2009 and ends at 5:00 p.m., New York City time, on March [    ], 2009 , unless extended by the Company in its sole discretion (as it may be
extended, the “Expiration Date”). The Common Stock is presently quoted on the OTC Bulletin Board under the symbol “PRWP.OB”. The Rights will not be listed for trading on any stock exchange or market or on the OTC Bulletin
Board. The Rights may not be sold, transferred or assigned, unless otherwise required by applicable law. 
 As described in the Prospectus,
Record Date Stockholders will receive one (1) Right for each share of Common Stock owned on the Record Date. 
 Each Right entitles the
holder (the “Rights Holders”) to purchase two shares of Common Stock at the subscription price of $[            ] per two shares (the “Basic Subscription
Right”). 

 Rights Holders who fully exercise their Basic Subscription Rights will be entitled to subscribe for
additional shares that remain unsubscribed as a result of any unexercised Basic Subscription Rights (the “Over-Subscription Right” and together with the Basic Subscription Right, the “Rights”). Each
Over-Subscription Right entitles the holder to subscribe for an additional amount equal to up to 400% of the shares of Common Stock for which such holder was otherwise entitled to subscribe (calculated prior to the exercise of any rights). If
sufficient remaining shares of Common Stock are available, all over-subscription requests will be honored in full. If requests for shares of Common Stock pursuant to the Over-Subscription Right exceed the remaining shares of Common Stock available,
the remaining shares of Common Stock will be allocated pro-rata among Rights Holders who over-subscribe based on the number of Rights then held. Rights may only be exercised for two whole shares of Common Stock; no fractional shares of Common Stock
will be issued in the Rights Offering. 
 The Rights will be evidenced by subscription certificates (the “Subscription
Certificates”). 
 Enclosed are copies of the following documents: 
  

	 	1.	Prospectus, dated February [    ], 2009; and 

  

	 	2.	Beneficial Owner Election Form. 

 THE MATERIALS
ENCLOSED ARE BEING FORWARDED TO YOU AS THE BENEFICIAL OWNER OF COMMON STOCK CARRIED BY US IN YOUR ACCOUNT BUT NOT REGISTERED IN YOUR NAME. EXERCISES OF RIGHTS MAY ONLY BE MADE BY US AS THE RECORD OWNER AND PURSUANT TO YOUR INSTRUCTIONS.

 Accordingly, we request instructions as to whether you wish us to elect to subscribe for any shares of Common Stock to which you are
entitled pursuant to the terms and subject to the conditions set forth in the enclosed Prospectus. However, we urge you to read the Prospectus carefully before instructing us to exercise any Rights. Your instructions to us should be forwarded as
promptly as possible in order to permit us to exercise the Rights on your behalf in accordance with the provisions of the offering. The Rights Offering will expire at 5:00 p.m., New York City time, on the Expiration Date. You will have no right
to rescind your subscription after receipt of your payment of the subscription price, except as described in the Prospectus. Rights not exercised at or prior to 5:00 p.m., New York City time, on the Expiration Date will expire. 
 If you wish to have us, on your behalf, exercise your Rights for any shares of Common Stock to which you are entitled, please so instruct us by
completing, executing and returning to us the Beneficial Owner Election Form included with this letter. 
 ANY QUESTIONS OR REQUESTS FOR
ASSISTANCE CONCERNING THE RIGHTS OFFERING SHOULD BE DIRECTED TO MACKENZIE PARTNERS, INC., THE INFORMATION AGENT, TOLL-FREE AT THE FOLLOWING TELEPHONE NUMBER: (800) 322-2885.

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