Document:

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                                                                    Exhibit 4.01

THIS NOTE IS A GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER
REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF.
UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN CERTIFICATED
FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TRUST
COMPANY, A NEW YORK CORPORATION ("DTC"), TO A NOMINEE OF DTC OR BY DTC OR ANY
SUCH NOMINEE TO A SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR
DEPOSITARY. UNLESS THIS NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF DTC
TO CITIGROUP GLOBAL MARKETS HOLDINGS INC. OR ITS AGENT FOR REGISTRATION OF
TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF
CEDE & CO. OR IN SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF
DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS
THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

No. R-1                                          INITIAL PRINCIPAL AMOUNT
CUSIP 173075 84 7                                REPRESENTED $63,000,000
                                                 representing 6,300,000 Notes
                                                 ($10 per Note)

                     CITIGROUP GLOBAL MARKETS HOLDINGS INC.
                  1.5% Principal-Protected Equity Linked Notes
     Based Upon the Dow Jones Global Titans 50 Index(SM) Due October 29, 2009

      Citigroup Global Markets Holdings Inc., a New York corporation
(hereinafter referred to as the "Company", which term includes any successor
corporation under the Indenture herein referred to), for value received and on
condition that this Note is not redeemed by the Company prior to October 29,
2009 (the "Stated Maturity Date"), hereby promises to pay to CEDE & CO., or its
registered assigns, the Maturity Payment (as defined below), on the Stated
Maturity Date. This Note will bear semi-annual payments of interest, is not
subject to any sinking fund, is not subject to redemption at the option of the
holder thereof prior to the Stated Maturity Date, and is not subject to the
defeasance provisions of the Indenture.

      Payment of the Maturity Payment with respect to this Note shall be made
upon presentation and surrender of this Note at the corporate trust office of
the Trustee in the Borough of Manhattan, The City and State of New York, in such
coin or currency of the United States as at the time of payment is legal tender
for payment of public and private debts.

      This Note is one of the series of 6,300,000 1.5% Principal-Protected
Equity Linked Notes Based Upon the Dow Jones Global Titans 50 Index(SM) (the
"Index") Due October 29, 2009 (the "Notes").

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INTEREST

      The Notes bear interest at the rate of 1.5% per annum. Interest will be
paid in cash semi-annually on each 29th day of each April and October commencing
on October 29, 2004 (each such date, an "Interest Payment Date"). Interest will
be payable to the persons in whose names the Notes are registered at the close
of business on the fifth Business Day preceding each Interest Payment Date.
Interest will be computed on the basis of a 360-day year of twelve 30-day
months. If an Interest Payment Date falls on a day that is not a Business Day,
the interest payment to be made on such Interest Payment Date will be made on
the next succeeding Business Day with the same force and effect as if made on
such Interest Payment Date, and no additional interest will accrue as a result
of such delayed payment.

      "Business Day" means any day that is not a Saturday, a Sunday or a day on
which the securities exchanges or banking institutions or trust companies in the
City of New York are authorized or obligated by law or executive order to close.

PAYMENT AT MATURITY

      On the Stated Maturity Date, holders of the Notes will receive for each
Note the Maturity Payment described below.

DETERMINATION OF THE MATURITY PAYMENT

      The Maturity Payment for each Note equals the sum of the initial principal
amount of $10 per Note plus the Interest Distribution Amount.

      The "Interest Distribution Amount" is calculated as follows:

            -     If the Index Return is less than or equal to the Interest
                  Received Percentage, the Interest Distribution Amount will
                  equal zero.

            -     If the Index Return is greater than the Interest Received
                  Percentage, the Interest Distribution Amount will equal the
                  product of will equal the product of:

               $10 * (Index Return - Interest Received Percentage)

      The "Index Return" will equal the compounded value of the Periodic Capped
Return for each Reset Period.

      The "Periodic Capped Return" for any Reset Period (including the Reset
Period ending at maturity) will equal:

                          Ending Value - Starting Value
                          -----------------------------
                                 Starting Value

provided that the Periodic Capped Return for any Reset Period shall not exceed
4%.

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      The "Interest Received Percentage" is 8.25%.

      A "Reset Period" is the period between any two consecutive Reset Dates.

      A "Reset Date" is the 26th day of each month, commencing May 26, 2004 and
ending on October 26, 2009.

      The "Starting Value" will be:

            -     For the initial Reset Period, 185.84, the closing value of the
                  Index on April 26, 2004.

            -     For each subsequent Reset Period, the Ending Value with
                  respect to the immediately preceding reset period.

      The "Ending Value" will be:

            -     For any Reset Period other than the Reset Period ending on the
                  Stated Maturity Date, the closing value of the Dow Jones
                  Global Titans 50 Index on the Reset Date at the end of the
                  period.

            -     For the Reset Period that ends on the Stated Maturity Date,
                  the Ending Value for closing value of the Dow Jones Global
                  Titans 50 Index on the date three Index Business Days before
                  the Stated Maturity Date.

      An "Index Business Day" means a day, as determined by the calculation
agent, on which the Index or any successor index is calculated and published and
on which securities comprising more than 80% of the value of the Index on such
day are capable of being traded on their relevant exchanges during the one-half
hour before the determination of the closing value of the Index. All
determinations made by the calculation agent will be at the sole discretion of
the calculation agent and will be conclusive for all purposes and binding on the
Company and the beneficial owners of the Notes, absent manifest error.

      A "Market Disruption Event" means, as determined by the calculation agent
in its sole discretion, the occurrence or existence of any suspension of or
limitation imposed on trading (by reason of movements in price exceeding limits
permitted by any relevant exchange or market or otherwise) of, or the
unavailability, through a recognized system of public dissemination of
transaction information, for a period longer than two hours, or during the
one-half hour period preceding the close of trading, on the applicable exchange
or market, of accurate price, volume or related information in respect of (a)
stocks which then comprise 20% or more of the value of the Index or any
successor index, (b) any options or futures contracts, or any options on such
futures contracts relating to the Index or any successor index, or (c) any
options or futures contracts relating to stocks which then comprise 20% or more
of the value of the Index or any successor index on any exchange or market if,
in each case, in the determination of the calculation agent, any such
suspension, limitation or unavailability is material. For the purpose of
determining whether a Market Disruption Event exists at any time, if trading in
a security included in the Index is

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materially suspended or materially limited at that time, then the relevant
percentage contribution of that security to the value of the Index will be based
on a comparison of the portion of the value of the Index attributable to that
security relative to the overall value of the Index, in each case immediately
before that suspension or limitation.

      If no closing value of the Index is available on any Index Business Day
because of a Market Disruption Event or otherwise, the value of the Index for
that Index Business Day, unless deferred by the calculation agent as described
below, will be the arithmetic mean, as determined by the calculation agent, of
the value of the Index obtained from as many dealers in equity securities (which
may include Citigroup Global Markets Inc. or any of the Company's other
subsidiaries or affiliates), but not exceeding three such dealers, as will make
such value available to the calculation agent. The determination of the value of
the Index by the calculation agent in the event of a Market Disruption Event may
be deferred by the calculation agent for up to five consecutive Index Business
Days on which a Market Disruption Event is occurring, but not past the Index
Business Day prior to the Stated Maturity Date.

DISCONTINUANCE OF THE DOW JONES GLOBAL TITANS 50 INDEX

      If Dow Jones discontinues publication of the Index or if it or another
entity publishes a successor or substitute index that the calculation agent
determines, in its sole discretion, to be comparable to the Index, then the
Ending Value of any succeeding Reset Date will be determined by reference to the
value of that index, which is referred to as a "successor index."

      Upon any selection by the calculation agent of a successor index, the
calculation agent will cause notice to be furnished to the Company and the
Trustee, who will provide notice of the selection of the successor index to the
registered holders of the Notes.

      If Dow Jones discontinues publication of the Index and a successor index
is not selected by the calculation agent or is no longer published on any Reset
Date, the periodic index level to be substituted for the Index for that Reset
Date will be a value computed by the calculation agent for that Reset Date in
accordance with the procedures last used to calculate the Index prior to any
such discontinuance.

      If Dow Jones discontinues publication of the Index prior to the
determination of the Interest Distribution Amount and the calculation agent
determines that no successor index is available at that time, then on each Index
Business Day until the earlier to occur of (a) the determination of the Interest
Distribution Amount and (b) a determination by the calculation agent that a
successor index is available, the calculation agent will determine the value
that is to be used in computing the Interest Distribution Amount as described in
the preceding paragraph as if such day were a Reset Date. The calculation agent
will cause notice of those daily closing values to be published not less often
than once each month in The Wall Street Journal (or another newspaper of general
circulation).

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      If a successor index is selected or the calculation agent calculates a
value as a substitute for the Index as described above, the successor index or
value will be substituted for the Index for all purposes, including for purposes
of determining whether an Index Business Day or Market Disruption Event occurs.

      All determinations made by the calculation agent will be at the sole
discretion of the calculation agent and will be conclusive for all purposes and
binding on the Company and the beneficial owners of the Notes, absent manifest
error.

ALTERATION OF METHOD OF CALCULATION

      If at any time the method of calculating the Index or a successor index is
changed in any material respect, or if the Index or a successor index is in any
other way modified so that the value of the Index or the successor index does
not, in the opinion of the calculation agent, fairly represent the value of that
index had the changes or modifications not been made, then, from and after that
time, the calculation agent will, at the close of business in New York, New
York, make those adjustments as, in the good faith judgment of the calculation
agent, may be necessary in order to arrive at a calculation of a value of a
stock index comparable to the Index or the successor index as if the changes or
modifications had not been made, and calculate the closing value with reference
to the Index or the successor index. Accordingly, if the method of calculating
the Index or the successor index is modified so that the value of the Index or
the successor index is a fraction or a multiple of what it would have been if it
had not been modified (e.g., due to a split in the Index), then the calculation
agent will adjust that index in order to arrive at a value of the index as if it
had not been modified (e.g., as if the split had not occurred).

GENERAL

      This Note is one of a duly authorized issue of debt securities of the
Company (the "Debt Securities"), issued and to be issued in one or more series
under a Senior Debt Indenture, dated as of October 27, 1993, as supplemented by
a First Supplemental Indenture, dated as of November 28, 1997, a Second
Supplemental Indenture, dated as of July 1, 1999, and as further supplemented
from time to time (the "Indenture"), between the Company and The Bank of New
York, as Trustee (the "Trustee", which term includes any successor trustee under
the Indenture), to which Indenture reference is hereby made for a statement of
the respective rights, limitations of rights, duties and immunities thereunder
of the Company, the Trustee and the holders of the Notes, and the terms upon
which the Notes are, and are to be, authenticated and delivered.

      If an Event of Default with respect to the Notes shall have occurred and
be continuing, the principal of the Notes may be declared due and payable in the
manner and with the effect provided in the Indenture. In such case, the amount
declared due and payable upon any acceleration of the Notes will be determined
by the calculation agent and will equal, for each Note, the maturity payment,
calculated as though the maturity of the Notes were the date of early repayment.
If a Bankruptcy proceeding is commenced in respect of Citigroup Global Markets
Holdings, the beneficial owner of a Note will not be permitted to make a claim
for unmatured interest and therefore, under Section 502(b)(2) of Title 11 of the
United States Code, the claim of the beneficial owner of a Note will be capped
at the payment at maturity calculated as though the maturity date

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of the Notes were the date of the commencement of the proceeding, plus an
additional amount of interest accrued on the principal amount of the Notes at
1.5% per annum up to the date of the commencement of the proceeding.

      In case of default in payment at maturity of the Notes, the Notes will
bear interest, payable upon demand of the beneficial owners of the Notes in
accordance with the terms of the Notes, from and after the maturity date through
the date when payment of the unpaid amount has been made or duly provided for,
at the rate of 4.5% per annum on the unpaid amount due.

      The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the
Company and the rights of the holders of the Debt Securities of each series to
be affected under the Indenture at any time by the Company and a majority in
aggregate principal amount of the Debt Securities at the time Outstanding of
each series affected thereby. The Indenture also contains provisions permitting
the holders of specified percentages in aggregate principal amount of the Debt
Securities of any series at the time Outstanding, on behalf of the holders of
all Debt Securities of such series, to waive compliance by the Company with
certain provisions of the Indenture and certain past defaults under the
Indenture and their consequences. Any such consent or waiver by the holder of
this Note shall be conclusive and binding upon such holder and upon all future
holders of this Note and of any Note issued upon the registration of transfer
hereof or in exchange herefor or in lieu hereof, whether or not notation of such
consent or waiver is made upon this Note.

      The holder of this Note may not enforce such holder's rights pursuant to
the Indenture or the Notes except as provided in the Indenture. No reference
herein to the Indenture and no provision of this Note or of the Indenture shall
alter or impair the obligation of the Company to pay the Maturity Payment with
respect to this Note, and to pay any interest on any overdue amount thereof at
the time, place and rate, and in the coin or currency, herein prescribed.

      All terms used in this Note which are defined in the Indenture but not in
this Note shall have the meanings assigned to them in the Indenture.

      Unless the certificate of authentication hereon has been executed by the
Trustee by manual signature, this Note shall not be entitled to any benefit
under the Indenture or be valid or obligatory for any purposes.

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      IN WITNESS WHEREOF, the Company has caused this instrument to be duly
executed under its corporate seal.

                              CITIGROUP GLOBAL MARKETS HOLDINGS INC.

                              By: /s/ Mark I. Kleinman
                                  -------------------------------------
                                  Name: Mark I. Kleinman
                                  Title: Executive Vice President
                                  and Treasurer

Corporate Seal
Attest:

By:     /s/ Douglas C. Turnbull
   -----------------------------------------------
     Name: Douglas C. Turnbull
     Title: Assistant Secretary

Dated: April 29, 2004

CERTIFICATE OF AUTHENTICATION

    This is one of the Notes referred to in
     the within-mentioned Indenture.

The Bank of New York,
as Trustee

By:  /s/ Geovanni Barris
     ---------------------------------------------
     Authorized Signatory

                                       7<PAGE>

                                                                   EXHIBIT 10.28

                                                                  March 16, 2004

Caraco Pharmaceutical Laboratories Ltd.
110 Elijah McCoy Drive
Detroit, MI 48202

Re $10,000,000 line of credit

Gentlemen or Ladies:

         Citibank, F.S.B. ("Citibank") is pleased to advise you it holds
available for Caraco Pharmaceutical Laboratories Ltd. (the "Borrower"), a
corporation organized and in good standing under the laws of the State of
Michigan, a line of credit (the "Line") in the amount of $10,000,000, subject to
the following terms an conditions:

1.       Description of the Line:

         Loans provided under the Line shall be evidenced by Citibank's Master
Note (the "Note") in the amount of the Line. Each advance thereunder shall bear
interest at a rate to be elected by the Borrower at the time of each advance
thereunder equal to either:

         Prime Rate Option: A rate equal to the prime rate of interest as
published in the Money Rates column of the Wall Street Journal from time to time
(the "Prime Rate"); any change in the Prime Rate shall take effect on the date
of the change in the Prime Rate, or

         LIBOR Rate Option: A rate equal to the Reserve Adjusted LIBOR, as such
term is defined in the Note, plus a margin of 100 basis points.

         Interest on the unpaid principal balance of the Note from time to time
outstanding shall be payable monthly in arrears commencing on the first day of
the month following the date of the first advance under the Note. Any advance
under the Line made by Citibank in its discretion shall be in an amount not less
than $100,000.

         In the case of a Prime Rate advance, such advance may be prepaid, in
whole or in part, in increments of not less than $100,000, without premium or
penalty.

         The Borrower agrees to indemnify Citibank and hold Citibank harmless
from any loss or expense that Citibank may sustain or incur, as more
particularly described in the Note should the Borrower make any prepayment of
the principal of an advance hereunder bearing interest at the LIBOR Rate or in
the event of a default by the Borrower in the payment or performance of any
terms of the Note or this line letter.

         There shall be available under the Line a sublimit for commercial
letters of credit (each, an "L/C" and collectively, the "L/Cs") and standby
letters of credit (each, a "SBLC" and collectively, the "SBLCs") in an amount
not exceeding $500,000 in the aggregate.

         Each L/C issued under the Line shall be governed by the terms and
conditions set forth in Citibank's Master Letter of Credit Agreement. There
shall be payable in respect of each L/C, a fee equal to -1/4% ($100.00 minimum)
upon the opening and 1/4% ($100.00 minimum) upon the negotiation thereof
together with Citibank's fees and charges therewith. The maximum tenor for each
L/C shall be one year.

<PAGE>

         The SBLC issued under the Line shall be evidenced by Citibank's
Agreement for Standby Letters of Credit which shall provide for the payment by
the Borrower of a fee equal to 1% per annum. The SB shall, by its terms, expire
not more than one (1) year after its issuance, but shall be automatically
renewable for successive one year periods, unless written notice of termination
is given by Citibank.

         Availability under the Line shall be limited to the aggregate principal
amount of the Collateral SBLC in favor of Citibank in form and substance
satisfactory to Citibank.

         The Borrower acknowledges and agrees that the Line is uncommitted and
requests for advances or extensions of credit thereunder shall be approved in
the discretion of Citibank, which may refuse to make an extension of credit
under the Line at any time without prior notice to the Borrower, and that the
performance or compliance by the Borrower of the agreements contained in this
letter, or in any other document or agreement evidencing or securing such
advances or extensions of credit. shall not obligate Citibank to make an advance
or provide an extension of credit thereunder.

         Subject to the terms and conditions hereof, the Line shall be available
until March 15, 2005.

2.       Purpose of the Line:

         The purpose of the Line shall be to support the Borrower's working
capital needs, debt redemption and capital expenditures.

3.       Security for the Line:

         The Line shall be secured by "irrevocable and unconditional" Standby
Letter(s) of Credit (the "Collateral SBLC") in favor of Citibank in form and
substance satisfactory to Citibank.

4.       Conditions Precedent:

         Prior to the Borrower's initial request for an advance under the Line:

         (a)      It shall have provided to Citibank:

                  (a)      A copy of the resolutions passed by the Borrower's
Board of Directors certified by its Secretary as being in full force and effect
authorizing the borrowing described herein and the execution of all documents
and agreements required by Citibank to evidence and secure the Line; and

                  (b)      A certified copy of the certificate of incorporation
of the Borrower.

         (b)      Citibank shall have received the Collateral SBLC in favor of
Citibank in the amount of $10,000,000 in form and substance satisfactory to
Citibank.

5.       Financial Reporting:

         The Borrower shall provide to Citibank:

         (a)      As soon as available, but in any event within one hundred
twenty (120) day after the last day of each fiscal year, a balance sheet of the
Borrower, as of such last day of the fiscal year, and statements of income and
retained earnings and cash flows for such fiscal year prepared in accordance
with generally accepted accounting principles consistently applied, in
reasonable detail, such statements to be audited by a firm of independent
certified public accountants satisfactory to Citibank.

<PAGE>

         (b)      As soon as available, but in any event within sixty (60) days
after the end of each fiscal quarter, a balance sheet of the Borrower and
statements of income and retained earnings and cash flows of the Borrower for
such quarter, and the portion of the fiscal year through such date all in
reasonable detail, such statements to be prepared by the Borrower in accordance
with generally accepted accounting principles consistently applied.

         Each of the financial statements specified in Sections (i) and (ii)
above shall be accompanied by a certificate signed by the president or chief
financial officer of the Borrower to the effect that such statements fairly
present the financial condition of the Borrower as of the balance sheet date and
results of the operations of the Borrower for the period(s) then ended in
accordance with generally accepted accounting principles consistently applied.

         (c)      Such other financial or additional information as Citibank may
from time to time request.

6.       Special Requirements:

         The Borrower agrees that the Line shall be supported by a negative
pledge agreement in form and substance satisfactory to Citibank.

7.       Origination Fee:

         In order to compensate Citibank for any costs attributable to
Citibank's due diligence review of the Borrower's financial condition and
business operations, including, without limitation, any credit and financial
analysis conducted by Citibank to determine whether the Line shall be made
available to the Borrower, the Borrower agrees to pay Citibank an administration
fee of $10,000. If the origination fee is no remitted herewith, the Borrower
authorizes Citibank to charge any of the Borrower's accounts maintained with
Citibank for the payment thereof.

8.       Acceptance:

         If the foregoing is acceptable, please so indicate by signing and
returning this letter together with the origination fee before March 29, 2004,
the date this letter will otherwise expire, unless extended in writing by
Citibank.

                                            Very truly yours,

                                            CITIBANK, F.S.B.
                                            By: CITIBANK, N.A., Servicing Agent

                                            By: /s/ Martin Efron
                                                --------------------------------
                                                    Martin Efron
                                                    Vice President

Agreed and Accepted this
19th day of March, 2004

CARACO PHARMACEUTICAL LABORATORIES LTD.

By: /s/  Jitendra N. Doshi
    ------------------------------
         Name: Jitendra N. Doshi
         Title: Chief Executive Officer

State of Michigan
County of Oakland, Acting in Wayne County

On this 19th day of March 2004, Jitendra Doshi personally appeared before me,
who is personally known to me to be the signer of the above instrument, and he
acknowledged signing of his own free will.

                                        By: /s/  Susan Banks-Williams, Ph.D.
                                            ------------------------------------
                                        Susan Banks-Williams, Ph.D
                                        Notary Public, State of Michigan
                                        My Commission Expires September 1, 2007

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