Document:

Exhibit 10.2

 Exhibit 10.2 
 Enanta has requested that portions of this document be accorded confidential treatment 
 pursuant to Rule 24b-2 promulgated under the Securities Exchange Act of 1934, as 
 amended. 
 COLLABORATION AND LICENSE AGREEMENT 

This COLLABORATION AND LICENSE AGREEMENT (“Agreement”) is made as of February 16, 2012 (“Effective
Date”), by and between Novartis Institutes for BioMedical Research, Inc., with its principal office at 250 Massachusetts Avenue, Cambridge, Massachusetts 02139 (“Novartis”) and Enanta Pharmaceuticals, Inc., with its
principal office at 500 Arsenal Street, Watertown, Massachusetts 02472 (“Enanta”). Novartis and Enanta are each referred to individually as a “Party” and together as the “Parties.” 

RECITALS 

WHEREAS, Novartis and its Affiliates are in the business of discovering, developing, manufacturing, marketing and selling pharmaceuticals
worldwide; 
 WHEREAS, Enanta owns or Controls the Enanta IP relating to the Enanta Compounds; 

WHEREAS, Enanta and Novartis are interested in generating Collaboration Compounds and new Enanta Compounds that target NS5A; and

 WHEREAS, Novartis wishes to obtain, and Enanta wishes to grant, exclusive rights to the Enanta Compounds and the
Collaboration Compounds in the Field and in the Territory on the terms and conditions set forth herein. 
 NOW, THEREFORE, in
consideration of the mutual covenants and agreements herein contained, the Parties agree as follows: 
  

	1.	DEFINITIONS AND INTERPRETATION 

  

	1.1	Definitions. Unless the context otherwise requires, the terms in this Agreement with initial letters capitalized, shall have the meanings set forth below, or the
meaning as designated in the indicated places throughout this Agreement. 

 “Accounting Standards”
means, with respect to Enanta, US GAAP (United States Generally Accepted Accounting Principles) and, with respect to Novartis, the IFRS (International Financial Reporting Standards), in each case, as generally and consistently applied
throughout the Party’s organization. Each Party shall promptly notify the other in writing in the event that it changes the Accounting Standards pursuant to which its records are maintained, it being understood that each Party may only use
internationally recognized accounting principles (e.g. IFRS, US GAAP, etc). 
 “Acquired Product” shall
have the meaning set forth in Section 4.3. 
 “Acquired Program” shall have the meaning set forth in
Section 4.3. 
 “Acquirer” shall have the meaning set forth in the definition of Change of Control.

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

 “Affiliate” means, with respect to a Party, any entity or person that
controls, is controlled by, or is under common control with that Party. For the purpose of this definition, ‘control’ or ‘controlled’ means, direct or indirect, ownership of fifty percent (50%) or more of the shares of stock
entitled to vote for the election of directors in the case of a corporation or fifty percent (50%) or more of the equity interest in the case of any other type of legal entity; status as a general partner in any partnership; or any other
arrangement whereby the entity or person controls or has the right to control the board of directors or equivalent governing body of a corporation or other entity or the ability to cause the direction of the management or policies of a corporation
or other entity. The Parties acknowledge that in the case of entities organized under the laws of certain countries where the maximum percentage ownership permitted by law for a foreign investor is less than fifty percent (50%), such lower
percentage shall be substituted in the preceding sentence, provided that such foreign investor has the power to direct the management and policies of such entity. 
 “Alliance Manager” shall have the meaning set forth in Section 5.1. 
 “Blended Rate” means (a) the total amount of royalties (stated in United States Dollars) that would be payable with respect to the relevant Product under Sections 11.3 and 11.4 in
all countries where royalties are due for Products as determined in accordance with the methodology provided in Section 11.5, without any applicable reduction in the royalty rate under Section 11.6 and/or 11.7, divided by (b) the
total Net Sales (stated in United States Dollars) of such Product in that same period in such countries, expressed as a percentage. 
 “Calendar Quarter” means the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30 and December 31.

 “Calendar Year” means a period of twelve (12) consecutive calendar months ending on December 31.

 “Change of Control” means, following the Effective Date, the occurrence that any Third Party, or group of
Third Parties acting in concert (collectively, an “Acquirer”): (a) becomes the beneficial owner, directly or indirectly, of more than fifty percent (50%) of the total voting power of the stock of Enanta or its Affiliates
then outstanding and normally entitled to vote in elections of its or their board of directors; (b) consolidates with or merges with or into Enanta or its Affiliates pursuant to a transaction in which more than fifty percent (50%) of the
total voting power of the voting securities outstanding of the surviving entity normally entitled to vote in elections of directors (or equivalent governing body) is not held by the Persons holding at least fifty percent (50%) of the
outstanding shares of the relevant entity preceding such consolidation or merger; (c) obtains, whether through conveyance, assignment, transfer or lease, all or substantially all of the assets of Enanta or its Affiliates; or (d) acquires
effective control of the management and policies of Enanta or its Affiliates. 
 “Claims” means all Third Party
demands, claims, actions, proceedings and liability (whether criminal or civil, in contract, tort or otherwise) for losses, damages, reasonable legal costs and other reasonable expenses of any nature whatsoever. 

  

					
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 “Co-Detail Notice” has the meaning set forth in Section 10.2.

 “Co-Detail Option Exercise Notice” has the meaning set forth in Section 10.3. 

“Co-Detailing/Co-Detail” means co-Detailing activities for the Products to be conducted by Enanta through its own sales
force in the United States in the event that Enanta exercises its rights under Section 10.2. 
 “Co-Detailing
Agreement” has the meaning set forth in Section 10.3(c). 
 “Collaboration Compound” means any
NS5A Compound that is not an Enanta Compound and that is conceived of, reduced to practice or created (i) in the course of performance of the Research Program, or (ii) in the course of any exercise by Novartis or its Affiliates of the
license granted in Section 3.1(b) or otherwise through the material use of any scientific Confidential Information of Enanta, including any complexes, chelates, clathrates, esters, salts, stereoisomers, enantiomers, pro-drug forms, hydrates,
solvates, polymorphs, other non-covalent derivatives, metabolites, and crystalline forms of any such compounds. 

“Collaboration IP” means all Patent Rights, Know-How and other intellectual property that is owned or Controlled by
either Party or its Affiliates, and (i) generated in the course of performance of the Research Program, or (ii) generated by Novartis or its Affiliates outside of the Research Program in the course of any exercise by Novartis or its
Affiliates of the licenses granted hereunder and directly related to or claiming the structure of any Collaboration Compound, or directly related to the use, formulation or manufacture of any such Collaboration Compound, provided that in no event
shall Collaboration IP include any Enanta Patents or any Enanta Know-How. 
 “Combination Products” mean any
pharmaceutical product (in any formulation) containing one or more active pharmaceutical ingredients in addition to a Licensed Compound. 
 “Commercialize” means to market, promote, distribute, import, export, offer to sell and/or sell Product and/or conduct other Commercialization, and “Commercialization”
means commercialization activities relating to Product(s), including activities relating to marketing, promoting, distributing, importing, exporting, offering for sale and/or selling Product(s). 

“Commercially Reasonable Efforts” means the diligent expenditure of those efforts and resources that Novartis or its
Affiliates would reasonably use were it developing or commercializing its own pharmaceutical product that is of similar market and profit potential and of similar risk profile at a similar stage in its product life as the applicable Product, taking
into account, among other things, anticipated product labeling, anticipated financial return, relevant medical and clinical considerations, anticipated regulatory environment and competitive market conditions, all as measured by the facts

  

					
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and circumstances at the time such efforts are due. For clarity, it is understood and acknowledged that Commercially Reasonable Efforts in the Development or Commercialization of a Product may
include sequential implementation of clinical trials and/or intervals between clinical trials for data interpretation and clinical program planning and approval, to the extent such implementation is consistent with the scientific, technical and
commercial factors relevant to Development or Commercialization of such Product in the relevant country. 
 “Competing
Product” means any product containing an NS5A Compound or related product, alone or in combination with another active pharmaceutical ingredient, which is not a Licensed Compound or Product. 

“Confidential Information” means all Know-How and other proprietary information and data of a financial, commercial or
technical nature which the disclosing Party or any of its Affiliates has supplied or otherwise made available to the other Party or its Affiliates, whether disclosure is made orally, in writing or in electronic form, and including any other
information deemed Confidential information as expressly provided in this Agreement. 
 “Control” or
“Controlled” means, with respect to any Know How, Patent Rights, other intellectual property rights, or any proprietary or trade secret information, the legal authority or right (whether by ownership, license or otherwise) of a
Party to grant a license or a sublicense of or under such Know How, Patent Rights, or intellectual property rights to the other Party as contemplated hereunder, or to otherwise disclose such proprietary or trade secret information to the other Party
as contemplated hereunder, without breaching the terms of any agreement with a Third Party, or misappropriating the proprietary or trade secret information of a Third Party. 
 “Detail” means a face to face discussion between a sales representative and a Prescriber for the purposes of discussing and informing such Prescriber of the characteristics of the
Products. When used as a verb, the terms “Detail” or “Detailing” means to perform a Detail. 

“Develop” or “Development” means preclinical and clinical drug development activities relating to
Licensed Compounds or Products, including, without limitation, test method development and stability testing, assay and audit development, toxicology, formulation, quality assurance and quality control development, statistical analysis, clinical
trials and regulatory affairs, and the preparation, filing and prosecution of new drug applications and Regulatory Approvals and their equivalent worldwide. 
 “EMA” means the European Medicines Agency or any successor entity thereto. 
 “Enanta Background IF” means, subject to Section 20.1, all Patent Rights, Know-How and other intellectual property that are Controlled by Enanta or its Affiliates during the Term
that are not included within Enanta IP or Collaboration IP and that are necessary or useful for the conduct of the Research Program or the Development, manufacture, Commercialization, use, importation or sale of Licensed Compound(s) or Product(s) in

  

					
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the Field and in the Territory, provided that Enanta Background IP shall not include Patent Rights, Know-How or other intellectual property to the extent relating to any compound whose structure
is proprietary to Enanta or its Affiliates and that is not an NS5A Compound, whether used alone or in combination with any other molecule, including without limitation any NS5A Compound. 

“Enanta Compound” means (i) the small molecule known as EDP-239 and any other NS5A Compound claimed in the Enanta
Patents, including any complexes, chelates, clathrates, esters, salts, stereoisomers, enantiomers, pro-drug forms, hydrates, solvates, polymorphs, other non-covalent derivatives, metabolites, and crystalline forms of such compounds to the extent
such structures are claimed in the Enanta Patents, and (ii) any other novel NS5A Compounds which are proprietary to and Controlled by Enanta as of the Effective Date, but which are not claimed in the Enanta Patents as of such date. 

“Enanta IP” means the Enanta Patents and Enanta Know-How. 

“Enanta Know-How” means any Know-How owned or Controlled by Enanta or any of its Affiliates relating to the Licensed
Compounds that is reasonably necessary or useful for the research, Development, manufacture, Commercialization, use, importation or sale of Licensed Compound(s) in the Field and in the Territory and that is not generated solely or jointly by Enanta
or its Affiliates in the course of performance of the Research Program. However, Enanta Know-How shall not include Know-How owned or Controlled by Enanta or its Affiliates to the extent not relating to NS5A Compounds, including Know-How directed to
combination therapies, and which is or may be or become owned or Controlled by Enanta or its Affiliates, and which is or may become exclusively licensed to Third Parties in connection with collaborations regarding proprietary compounds directed to
HCV-relevant targets other than NS5A. 
 “Enanta Patents” means the patents and patent applications identified
in Exhibit A and all Patent Rights claiming priority thereto, and any other Patent Rights that are not Collaboration IP and are owned or Controlled by Enanta or any of its Affiliates to the extent they include claims to novel NS5A Compounds.
However, Enanta Patents shall not include claims in Patent Rights not listed in Exhibit A owned or Controlled by Enanta or its Affiliates which do not claim Enanta’s novel NS5A Compound structures, including claims directed to
combination therapies, and which are or may be or become owned or Controlled by Enanta or its Affiliates, and which are or may become exclusively licensed to Third Parties in connection with collaborations regarding Enanta’s proprietary
compounds directed to HCV-relevant targets other than NS5A. 
 “Encumbrance” means any claim, charge, equitable
interest, hypothecation, lien, mortgage, pledge, option, license, assignment to a Third Party, power of sale, retention of title by a Third Party, right of pre-emption, right of first refusal or security interest of any kind. 

“FDA” means the United States Food and Drug Administration or any successor entity thereto. 

  

					
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 “Field” means all uses. 

“First Commercial Sale” means the first sale of a Product by or under the authority of Novartis or an Affiliate, or a
sublicensee of Novartis or of a Novartis Affiliate, to a Third Party in a country in the Territory following Regulatory Approval of such Product in that country or, if no such Regulatory Approval or similar marketing approval is required, the date
upon which such Product is first commercially launched in such country; provided that First Commercial Sale shall not include any distribution or other sale solely for so-called treatment IND sales, named patient sales, compassionate or emergency
use sales and pre-license sales. 
 “FPFV” means the administration of the first dose of a Licensed Compound or
Product to the first patient (or volunteer, as relevant) while participating in a clinical trial. 
 “FTE Rate”
shall mean a rate of [*****] per annum based on the yearly time for a full-time equivalent scientific employee during the Research Term, consisting of a total of [*****] hours per annum (“FTE”), to be pro-rated on a daily basis if
necessary (per annum amount to be divided by [*****] to produce the rate per whole day consisting of eight hours); such rate to be restricted to scientific work and managerial activities related directly to the Research Program. For the avoidance of
doubt, such rate includes all benefits, travel, overhead and any other expenses. 
 “Generic Equivalent” means
any product with the same active ingredient and administration route as the Product bioequivalent to and substitutable (i.e., “AA” or “AB” therapeutic equivalence code or other therapeutic equivalence code hereafter created with
similar meaning) for the Product and that is sold under an ANDA or NDA pursuant to the FDC Act, or pursuant to the applicable law of the relevant jurisdiction. 
 “IND” means an Investigational New Drug application in the US filed with the FDA or the corresponding application for the investigation of Products in any other country or group of
countries, as defined in the applicable laws and regulations and filed with the Regulatory Authority of the relevant country or group of countries. 
 “Insolvency Event” means, in relation to either Party, any one of the following: (a) that Party becomes insolvent (as determined under the laws of that Party’s jurisdiction of
organization); (b) that Party is the subject of voluntary or involuntary bankruptcy proceedings instituted on behalf of or against such Party (except for involuntary bankruptcy proceedings which are dismissed within sixty (60) days);
(c) an administrative receiver, receiver and manager, interim receiver, custodian, sequestrator or similar officer is appointed in respect of that Party; (d) a resolution shall have been passed by that Party’s directors or
stockholders to wind up that Party, other than a resolution for the solvent reconstruction or reorganization of that Party; (e) a resolution shall have been passed by that Party’s directors or stockholders to make an application for an
administration order or to appoint an administrator; or (f) that Party proposes or makes any general assignment, composition or arrangement with or for the benefit of all or some of that Party’s creditors or makes or suspends or threatens
to suspend making payments to all or some of that Party’s creditors or the Party submits to any type of voluntary arrangement. 

  

					
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 “Invoice” shall mean an invoice substantially in the form of Exhibit
C. 
 “Joint Steering Committee” or “JSC” means the committee established as set forth in
Section 5.2. 
 “Know-How” means all technical information, know-how and data, including inventions
(whether patentable or not), discoveries, trade secrets, specifications, instructions, processes, formulae, materials, expertise and other technology applicable to compounds, formulations, compositions, products or to their manufacture, development,
registration, use or commercialization or methods of assaying or testing them or processes for their manufacture, formulations containing them, compositions incorporating or comprising them and including all biological, chemical, pharmacological,
biochemical, toxicological, pharmaceutical, physical and analytical, safety, quality control, manufacturing, preclinical and clinical data, instructions, processes, formulae, expertise and information, regulatory filings and copies thereof, relevant
to the development, manufacture, use or commercialization of and/or which may be useful in studying, testing, development, production or formulation of products, or intermediates for the synthesis thereof. 

“Knowledge” means the actual knowledge of Enanta. 

“Licensed Compound” means any Enanta Compound or Collaboration Compound. 

“Loss of Market Exclusivity” means, with respect to any Product in any country, the following has occurred: (a) the
Net Sales of such Product in that country in any Calendar Year are less than [*****] in any Calendar Year of such Product in that country immediately preceding the launch of a Generic Equivalent; and (b) the decline in such sales is
attributable in material part to the marketing or sale in such country of a Generic Equivalent of such Product by a Third Party. 

“MAA” means an application for the authorization to market the Product in any country or group of countries outside the
United States, as defined in the applicable laws and regulations, and filed with the Regulatory Authority, of a given country or group of countries. 
 “Major EU Country” means any of France, Germany, Italy, Spain and the United Kingdom. 
 “Milestones” means the milestone events relating to the Products as set forth in Section 11.2. 
 “Milestone Payments” means the payments to be made by Novartis to Enanta upon the achievement of the corresponding Milestones as set forth in Section 11.2. 

“NDA” means a New Drug Application in the United States for authorization to market the Product, as defined in the
applicable laws and regulations of, and filed with, the FDA. 

  

					
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 “Net Sales” means, with respect to any Product, the gross amount invoiced
by or on behalf of Novartis or any of its Affiliates or its or its Affiliates’ sublicensees (a “Seller”) for such Product sold to Third Parties (other than to any such sublicensees for resale) in bona fide, arm’s length
transactions, less deductions from gross sales booked on an accrual basis as determined in accordance with Novartis’ Accounting Standards as consistently applied, less a deduction of [*****] for uncollectible amounts on previously sold items.
The deductions from gross sales in accordance with Novartis Accounting Standards may include, without limitation, the following: 
  

	 	(i)	normal trade and cash discounts actually given; 

  

	 	(ii)	amounts repaid or credited by reasons of defects, rejections, recalls or returns; 

 

	 	(iii)	rebates and chargebacks granted to customers and third parties (including, without limitation, Medicare, Medicaid, Managed Healthcare and similar types of rebates);

  

	 	(iv)	any amounts recorded in gross revenue associated with goods provided to customers for free; 

 

	 	(v)	amounts provided or credited to customers through coupons and other discount programs to the extent consistent with Seller’s normal practices;

  

	 	(vi)	delayed ship order credits, discounts or payments related to the impact of price increases between purchase and shipping dates; 

 

	 	(vii)	fee for service payments to customers for any non-separable services (including compensation for maintaining agreed inventory levels and providing information) to the
extent consistent with Seller’s normal practices; and 

  

	 	(viii)	other specifically identifiable deductions substantially similar to those itemized above in accordance with Novartis’ Accounting Standards.

 With respect to the calculation of Net Sales: 

 

	 	(1)	Net Sales shall only include the value charged or invoiced on the first arm’s length sale to a Third Party, and sales between or among Novartis and its Affiliates
and any sublicensees of either shall be disregarded for purposes of calculating Net Sales; 

  

	 	(2)	If a Product is delivered to the Third Party before being invoiced (or is not invoiced), Net Sales will be calculated at the time that the revenue recognition criteria
under Novartis Accounting Standards are met; 

  

					
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	 	(3)	In the case of any sale of any Product that is not an arm’s-length transaction exclusively for cash, Net Sales shall be calculated as above on the fair market
value of the non-cash consideration received as reasonably determined by Novartis. 

  

	 	(4)	In the event that the Product is sold as a Combination Product, the Net Sales will be calculated by multiplying the Net Sales of the Combination Product by the
fraction, A/(A+B) where A is the weighted (by sales volume) average sale price in the relevant country of the Product containing the Licensed Compound as the sole active ingredient in finished form, and B is the weighted average sale price (by sales
volume) in that country of the product(s) containing the other active pharmaceutical ingredient(s) as the sole active ingredient(s) in finished form. Regarding prices comprised in the weighted average price when sold separately referred to above, if
these are available for different dosages from the dosages of Licensed Compound and other active pharmaceutical ingredient(s) that are included in the Combination Product, then Novartis shall be entitled to make a reasonable proportional adjustment
to such prices in calculating the royalty-bearing Net Sales of the Combination Product following consultation with Enanta. If the product(s) containing the Licensed Compound or the other active pharmaceutical ingredient(s) as the sole active
ingredient(s) are not sold as such and thus the weighted average sale price cannot be determined, the calculation of Net Sales for Combination Products will be agreed by the Parties at least thirty (30) days prior to the First Commercial Sale
of such Combination Product based on the relative value contributed by each active pharmaceutical ingredient (each Party’s agreement not to be unreasonably withheld or delayed). 

“Novartis Exclusivity Period” shall have the meaning set forth in Section 4.2. 

“NS5A Compound” shall mean a molecule: (a) to which [*****] that are [*****] to its inhibitory effects contain
[*****]; (b) whose activity against [*****] that is required for HCV replication is [*****]; and (c) that inhibits replication of [*****]. 
 “Patent Rights” means all patents and patent applications, including all divisionals, continuations, substitutions, continuations-in-part, re-examinations, reissues, additions, renewals,
extensions, registrations, and supplemental protection certificates and the like of any of the foregoing. 

“Person” means any individual, partnership, limited liability company, firm, corporation, association, trust,
unincorporated organization or other entity. 
 “Phase I Clinical Trial” means a study in humans which provides
for the first introduction into humans of a product, conducted in normal volunteers or patients to get information on product safety, tolerability, pharmacological activity or pharmacokinetics, as more fully defined in 21 C.F.R. § 312.21(a) (or
the foreign equivalent thereof). 
 “Phase II Clinical Trial” means a study in humans of the safety, dose
ranging and efficacy of a product, which is prospectively designed to generate sufficient data (if successful) to commence pivotal clinical trials, as further defined in 21 C.F.R. § 312.21(b) (or the foreign equivalent thereof). 

  

					
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 “Phase III Clinical Trial” means a controlled study in humans of the
efficacy and safety of a product, which is prospectively designed to demonstrate statistically whether such product is effective and safe for use in a particular indication in a manner sufficient to file an application to obtain Regulatory Approval
to market the product, as further defined in 21 C.F.R. § 312.21(c) (or the foreign equivalent thereof). 

“Prescriber” means a healthcare professional authorized to prescribe a Product or issue hospital orders for a Product, or
those other allied professionals that are part of the treatment team and who are recognized for this purpose in the Commercialization plan, as applicable. 
 “Prior CDA” means the Confidentiality Agreement between the Parties dated as of September 30, 2009 and amended on November 17, 2011, and the Confidentiality Agreement between
Parties dated September 9, 2011. 
 “Product” means any pharmaceutical preparation (including drug
substance and drug product) incorporating a Licensed Compound as an active ingredient, alone or in combination with other active ingredients. 
 “Regulatory Approval” means any and all approvals (including any applicable governmental price and reimbursement approvals), licenses, registrations, or authorizations of any Regulatory
Authority that are necessary for the marketing and sale of a Product in the relevant country or group of countries. 

“Regulatory Authority” means any governmental agency or authority responsible for granting Regulatory Approvals for
Products, including the FDA, EMA and any corresponding national or regional regulatory authorities, as relevant. 

“Regulatory Filings” means, with respect to the Licensed Compound(s) or Product(s), any submission to a Regulatory
Authority of any appropriate regulatory application, and shall include, without limitation, any submission to a regulatory advisory board, marketing authorization application, and any supplement or amendment thereto. For the avoidance of doubt,
Regulatory Filings shall include any IND, NDA or the corresponding application in any other country or group of countries. 

“Research Plan” means the research plan attached as Exhibit B to this Agreement and any amendments thereto.

 “Research Program” means all research and drug discovery activities conducted solely or jointly by the
Parties during the Research Term pursuant to the Research Plan. 
 “Research Term” means the period of funded
research described in Section 2.3 (as may be extended in accordance therewith and as shall terminate if the Term earlier terminates). 

  

					
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 “Royalty Term” shall have the meaning set forth in Section 11.3(b).

 “Sales and Royalty Report” means a written report or reports showing, on a Product-by-Product, and
country-by-country basis, each of: (a) the Net Sales of each Product in each country in the Territory during the reporting period by Novartis and its Affiliates and their respective sublicensees; (b) the royalties payable, in United States
Dollars, which shall have accrued hereunder with respect to such Net Sales; (c) withholding taxes, if any, required by applicable law to be deducted with respect to such royalties; and (d) the rate of exchange used by Novartis in
determining the amount of United States Dollars payable hereunder, as determined in accordance with Section 12.2. If no royalty or payment is due for any reporting period hereunder, Novartis shall so report. 

“Senior Officers” means, for Novartis, the Chief Executive Officer of Novartis or his/her designee, and for Enanta, the
Chief Executive Officer of Enanta or his/her designee. 
 “Significant Pharmaceutical Company” means, with
respect to a given Change of Control transaction, a company in the pharmaceutical industry that, in its most recent fiscal year completed prior to the announcement of such Change of Control had annual sales in excess of [*****], as reflected in such
company’s financial statements, based on the prevailing currency exchange rates in effect on the last business day of such fiscal year as quoted at Bloomberg.com, as relevant. 

“Term” shall have the meaning set forth in Section 15.1. 

“Territory” means worldwide. 
 “Third Party” means any Person other than a Party or an Affiliate of a Party. 
 “United States” or “US” means the United States of America, its territories and possessions. 
 “USD” or “$” means United States Dollars, the lawful currency of the United States. 
 “Valid Claim” means: (a) a claim of an issued and unexpired patent under the Enanta IP or Collaboration IP, or a supplementary protection certificate thereof, which has not been held
permanently revoked, unenforceable or invalid by a decision of a court, patent office or other forum of competent jurisdiction, unappealable or unappealed within the time allowed for appeal and that is not admitted to be invalid or unenforceable
through reissue, disclaimer or otherwise (i.e., only to the extent the subject matter is disclaimed or is sought to be deleted or amended through reissue); or (b) a claim of a pending patent application under the Enanta IP or Collaboration IP
that has not been abandoned, finally rejected or expired without the possibility of appeal or refiling; provided that “Valid Claim” shall exclude any such claim in such a pending application that has not been granted within six
(6) years following the earliest priority filing date for such claim (unless and until such claim is granted). 
  

	1.2	Interpretation. In this Agreement, unless otherwise specified: 

  

	 	(a)	“includes” and ‘including’ shall mean respectively includes and including without limitation; 

  

					
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	 	(b)	a Party includes its permitted assignees and/or the respective successors in title to substantially the whole of its undertaking; 

 

	 	(c)	a statute or statutory instrument or any of their provisions is to be construed as a reference to that statute or statutory instrument or such provision as the same may
have been or may from time to time hereafter be amended or re-enacted; 

  

	 	(d)	words denoting the singular shall include the plural and vice versa and words denoting any gender shall include all genders; 

 

	 	(e)	the Exhibits and other attachments form part of the operative provision of this Agreement and references to this Agreement shall, unless the context otherwise requires,
include references to the Exhibits and attachments; 

  

	 	(f)	the headings in this Agreement are for information only and shall not be considered in the interpretation of this Agreement; 

 

	 	(g)	general words shall not be given a restrictive interpretation by reason of their being preceded or followed by words indicating a particular class of acts, matters or
things; and 

  

	 	(h)	the Parties agree that the terms and conditions of this Agreement are the result of negotiations between the Parties and that this Agreement shall not be construed in
favor of or against any Party by reason of the extent to which any Party participated in the preparation of this Agreement. 

  

	2.	RESEARCH PROGRAM. 

  

	2.1	Goal. The objective of the Research Program shall be to discover, characterize, and optimize Enanta Compounds and/or Collaboration Compounds suitable for
Development and Commercialization by Novartis and its Affiliates as Product(s). 

  

	2.2	 Research Plan; Recordkeeping. During the Research Term, each Party and its Affiliates shall use commercially reasonable efforts to perform their
obligations under the Research Plan including by applying such tools, assays, reagents, capabilities and the like as are useful to the Research Program, based on the application of reasonable scientific judgment. An initial outline of the Research
Plan shall be attached to this Agreement as Exhibit B. The final Research Plan, shall be approved by the JSC within thirty (30) days after the Effective Date. Each Party and its Affiliates shall maintain complete and accurate
records of all work, results, data, and developments made pursuant to its efforts under the Research Plan. Such records shall fully and properly reflect all work done and results in sufficient detail and in good scientific manner appropriate for
patent and regulatory purposes. Each Party and its Affiliates shall grant to the other Party and its Affiliates reasonable access to all data (including, without limitation, all primary data and

  

					
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data contained in laboratory notebooks) that is generated in the course of performance of the Research Program. Each Party shall maintain such laboratory notebooks and associated accessory
records substantially in accordance with the requirements of Exhibit E. Novartis and its Affiliates shall also have the right, at reasonable intervals and upon reasonable notice to Enanta, to have authenticated copies of such records
made to use and transfer as permitted hereunder. Any data not otherwise contained in laboratory notebooks and relevant to the Research Program or to Collaboration IP shall be provided to Novartis upon reasonable request in a format mutually agreed
by the Parties. In the event of a termination of this Agreement by Enanta pursuant to Section 15.2(a) or 15.4 or by Novartis pursuant to 15.3, Enanta shall have the right, at reasonable intervals and upon reasonable notice to Novartis, to have
authenticated copies made of Novartis’ laboratory notebooks and associated accessory records relevant to the Research Program or to Collaboration IP, to use and transfer as permitted hereunder, and any data not otherwise contained in laboratory
notebooks and relevant to the Research Program or to Collaboration IP shall be provided to Enanta upon reasonable request in a format mutually agreed by the Parties. 

 

	2.3	 Term and Scope of Research Program. The Research Program shall commence on the Effective Date and shall continue until the first (1st) anniversary of the Effective Date (the “Research
Term”). No later than [*****] months prior to expiration of the Research Term, the Parties may agree to extend the Research Term and shall discuss, in good faith, the scope of additional research funding to be provided to Enanta by Novartis
and the proposed Research Plan. In the event of a Change of Control, Novartis may terminate the Research Program by providing thirty (30) days’ prior written notice to Enanta. 

 

	3.	LICENSES 

  

	3.1	License Grant. 

  

	 	(a)	Subject to the terms and conditions of this Agreement, Enanta and its Affiliates hereby grant to Novartis and its Affiliates an exclusive (even as to Enanta and its
Affiliates), royalty-bearing, sublicensable (pursuant to Section 3.2) license, under the Enanta IP and the Collaboration IP to Develop, have developed, make, have made, use, distribute, have distributed, export, have exported, import, have
imported, promote, have promoted, market, have marketed, sell, have sold and offer to sell and otherwise Commercialize the Licensed Compound(s) and Product(s) in the Field and in the Territory. 

 

	 	(b)	Subject to the terms and conditions of this Agreement, Enanta and its Affiliates hereby grant to Novartis and its Affiliates an exclusive (even as to Enanta and its
Affiliates), royalty-bearing, sublicensable (pursuant to Section 3.2(c)) license, under the Enanta IP and the Collaboration IP to research Licensed Compound(s) and Product(s) for exploitation in the Field and in the Territory pursuant to the
license granted in (a) above. 

  

					
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	 	(c)	The exclusive licenses granted above shall be subject to Enanta’s right to perform those aspects of the Research Program required to be performed by Enanta as
provided in this Agreement and described in the Research Plan, or as otherwise approved by the JSC. 

  

	3.2	Sublicensing and Subcontracting Rights. 

  

	 	(a)	Novartis and its Affiliates may sublicense the rights granted by Enanta under Section 3.1(a) of this Agreement at any time at its/their sole discretion and without
approval of Enanta, provided that Novartis shall remain responsible for the performance of this Agreement and shall cause such Third Party to comply with all applicable terms and conditions of this Agreement. 

 

	 	(b)	Notwithstanding any other provision of this Agreement, neither Novartis nor any of its Affiliates shall have the right to grant any sublicense which is a Naked Patent
License to any Third Party under any Patent Rights within the Enanta IP or any Patent Rights within the Collaboration IP that are owned solely by Enanta without the prior written consent of Enanta, which consent shall not be unreasonably withheld,
conditioned, or delayed. For purposes hereof, a “Naked Patent License” shall mean a sublicense under the relevant Patent Rights granted to a Third Party and permitting the Development or Commercialization of a Licensed Compound or
Product that was not under active Development or Commercialization by Novartis under the terms of this Agreement as of the time the relevant sublicense is granted. For clarity, this Section shall not prohibit any activities permitted by
Section 3.2(c) below. 

  

	 	(c)	In addition, Novartis may subcontract to Third Parties the performance of tasks and obligations reasonably related to Novartis’ research, Development and
Commercialization of Licensed Compounds and Products hereunder as Novartis deems reasonably appropriate, which subcontract may include a sublicense of rights necessary to performance of the subcontract as reasonably required, provided that Novartis
shall at all times remain primarily responsible and liable to Enanta for all such activities as if such activities had been undertaken by Novartis, for any failure of any subcontractor to comply with the terms of this Agreement, and Novartis shall
be fully liable to accordingly indemnify Enanta against any loss, damages, costs, claims or expenses which are awarded against, or incurred by Enanta as a result of any breach by any subcontractor of any of the provisions of the relevant
subcontract, as if the breach had been that of Novartis. 

  

	3.3	Enanta Background IP. Subject to Section 20.1, Enanta and its Affiliates hereby grant to Novartis and its Affiliates a non-exclusive license under the
Enanta Background IP (with the right to sublicense solely in connection with, and as reasonably relevant to, a sublicense granted pursuant to Section 3.2) to research, Develop, have developed, make, have made, use, distribute, have distributed,
export, have exported, import, have imported, promote, have promoted, market, have marketed, sell, have sold and offer to sell and otherwise Commercialize the Licensed Compound(s) and Product(s) in the Field in the Territory.

  

					
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	3.4	No Other Rights. Novartis and its Affiliates expressly acknowledge and agree that they will not use Confidential Information of Enanta in the research,
development, or commercialization of any NS5A Compound that is not a Product, as defined in this Agreement, and shall have no rights to do so under any license or other right granted herein. Each Party expressly reserves and retains all intellectual
property rights not expressly granted herein, and no right or license under any Patent Rights, trademarks, Know-How or other proprietary rights of either Party is granted or shall be granted by implication. Except as otherwise expressly provided in
this Agreement, neither Party shall receive any rights under this Agreement to own, use or access the Patent Rights, Know-How or other intellectual property of the other Party. 

 

	4.	EXCLUSIVITY 

  

	4.1	Enanta Exclusivity to Novartis. During the Term of this Agreement, other than the performance of the Research Program during the Research Term, Enanta and its
Affiliates will not, alone or in collaboration with a Third Party, anywhere in the Territory, research, develop, manufacture or commercialize a Competing Product. Notwithstanding the foregoing, such prohibition shall not prevent Enanta and its
Affiliates from participating in (including without limitation receiving payments under) agreements with Third Parties with respect to products which include another active pharmaceutical ingredient used in combination with an NS5A Compound, so long
as Enanta has no active research or development role with respect to such NS5A Compound, and so long as Enanta provides no Enanta Know-How, and grants no rights under the Enanta IP or Collaboration IP, with respect to the research, development,
manufacture or commercialization of such NS5A Compounds under any such agreement. Notwithstanding anything in this Agreement to the contrary, in the event of a Change of Control of Enanta, the exclusivity obligations of Enanta set forth above shall
not restrict the research, development or commercialization of any compound, product or program owned or controlled by the relevant Acquirer, so long as all such activities are conducted independent of the Enanta scientific team (as it exists at the
date of consummation of the Change of Control) and without use of any proprietary Enanta Know-How, Enanta IP or Collaboration IP that is exclusively licensed to Novartis hereunder. 

 

	4.2	Novartis Exclusivity to Enanta. Except as set forth in Sections 4.3 and 4.4, Novartis and its Affiliates will not, directly or indirectly, [*****] until the
earlier of: [*****] anniversary [*****]; and (b) [*****] (subject to any extension as provided below, the “Novartis Exclusivity Period”). 

 

	4.3	Acquired Products and Acquired Programs. The provisions of Section 4.2 shall not apply to the continued actions relating to any Competing Product or any
NS5A Compound research or Development program, rights to which were acquired by Novartis or its Affiliates as the result of an acquisition by Novartis or its Affiliates of a Third Party, [*****] (such product, an “Acquired
Product”, and such program, an “Acquired Program”). In the event that Novartis or its Affiliates acquire an Acquired Product and/or Acquired Program, Novartis agrees that: 

 

	 	(a)	activities of Novartis and its Affiliates relating to any Acquired Product and Acquired Program will be staffed independently, except at senior executive levels, from
the activities conducted hereunder with respect to research, Development and Commercialization of Licensed Compounds and Products; 

  

					
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	 	(b)	the licenses and rights granted by Enanta to Novartis and its Affiliates hereunder do not extend to such Acquired Product or Acquired Program; 

 

	 	(c)	the commitment of Novartis and its Affiliates to use Commercially Reasonable Efforts pursuant to Sections 7.2 and 9.1 hereof shall not be affected by any consideration
of the Acquired Product or Acquired Program, and Novartis and its Affiliates shall use all reasonable efforts to ensure that the Licensed Compound(s) and Product(s) Development timelines will be unaffected by the acquisition;

  

	 	(d)	any clinical trials with respect to any Acquired Product for which patient enrollment has commenced as of the consummation of the acquisition may be completed, but no
new clinical trials may be commenced with respect to any such Acquired Product until the Novartis Exclusivity Period has expired; 

  

	 	(e)	if the Acquired Program is in the preclinical or discovery stage, then no patient enrollment in a clinical trial of any Acquired Product will be commenced by Novartis
or any Affiliate until the Novartis Exclusivity Period has expired; 

  

	 	(f)	Novartis and its Affiliates may not use any Enanta Confidential Information or, during the Novartis Exclusivity Period, non-public clinical data resulting from the
Licensed Compound(s) or Product(s), for the benefit of such Acquired Product or Acquired Program; and 

  

	 	(g)	if a clinical trial of an Acquired Product permitted under subsection (d) above continues after [*****], then, unless [*****], the Novartis Exclusivity Period
shall be extended by the amount of time that such clinical trial continues after [*****], but in no event shall such extension period exceed [*****] months. 

 

	4.4	[*****] 

  

	5.	GOVERNANCE 

  

	5.1	 Alliance Managers. Within thirty (30) days following the Effective Date, each Party will appoint (and notify the other Party of the
identity of) a senior representative having a general understanding of pharmaceutical development and commercialization issues to act as its alliance manager under this Agreement (“Alliance Manager”). The Alliance Managers will
serve as the contact point between the Parties and will be primarily responsible for facilitating the flow of information and otherwise promoting communication, coordination and collaboration between the Parties, including periodic

  

					
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communications between the Parties in connection with the Parties’ reporting requirements; providing single point communication for seeking consensus both internally within the respective
Party’s organization and together regarding key global strategy and planning issues, as appropriate, including facilitating review of external corporate communications; and raising cross-Party and/or cross-functional disputes in a timely
manner. Each Party may replace its Alliance Manager on written notice to the other Party. 

  

	5.2	Joint Steering Committee. 

  

	 	(a)	The Parties will establish a Joint Steering Committee, composed of three (3) senior personnel of Enanta and three (3) senior personnel of Novartis (one
(1) of which will be the Party’s Alliance Manager) and which personnel for each Party, collectively, shall have a general understanding of drug research, manufacturing, Development and Commercialization issues. 

 

	 	(b)	Within thirty (30) days following the Effective Date, each Party will designate its initial members to serve on the JSC and notify the other Party of the dates of
availability for the first meeting of the JSC. Each Party may replace its representatives on the JSC on prior written notice to the other Party. 

  

	 	(c)	The JSC will: (i) approve and revise the Research Plan; (ii) oversee the research activities pursuant to the Research Plan, including the research budget;
(iii) review and discuss research activities conducted by Novartis or its Affiliates with respect to Licensed Compound(s); (iv) review and discuss Development activities and plans with respect to Licensed Compound(s) and Product(s);
(v) review and discuss Novartis’ Commercialization plans and strategies with respect to the Product(s); and (vi) consider and act upon such other matters as specified in this Agreement. 

 

	 	(d)	The JSC also may, at any time it deems necessary or appropriate, establish additional joint committees and delegate such of its responsibilities as it determines
appropriate to such joint committees. 

  

	5.3	Meetings of the Joint Steering Committee. 

  

	 	(a)	The JSC shall meet [*****] and at such other times as the Parties may agree during [*****], after which the JSC shall meet [*****] month intervals until [*****], after
which it shall be dissolved. The first meeting of the JSC shall be held as soon as reasonably practicable, but in no event later than sixty (60) days following the Effective Date. At the first meeting of the JSC, the members shall reasonably
and in good faith determine how it will function with respect to minutes, agendas, timelines and other administrative matters. Meetings shall be held at such place or places as are mutually agreed or by teleconference or videoconference.

  

					
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	 	(b)	Each Party may from time to time invite a reasonable number of participants, in addition to its representatives, to attend JSC meetings in a non-voting capacity, with
the consent of the other Party (which shall not be unreasonably withheld). 

  

	 	(c)	[*****] to act as chairperson of the JSC. The chairperson shall set agendas for JSC meetings provided that the agendas will include any matter requested by either
Party. 

  

	5.4	Decision Making. Each Party shall in good faith consult with the other and take such other Party’s views into account in respect of any matter before the
JSC or any other committee established by the Parties hereunder, it being understood and agreed that Novartis shall have sole control and decision-making with respect to the research, Development, manufacture and Commercialization of the Licensed
Compound(s) and Product(s), subject to the terms of this Agreement. If consensus cannot be reached with respect to any issue under the purview of the JSC, then the resolution and/or course of conduct shall be determined by Novartis, in its sole
reasonable discretion. In exercising its final decision-making authority with respect to JSC decisions, Novartis shall act in accordance with the objectives of the Research Program, and the terms of this Agreement, and shall exercise good faith,
prudent scientific and business judgment in accordance with the standards Novartis applies to other projects and products of similar scientific and commercial potential. Notwithstanding the foregoing, Enanta shall not be required to take any action
by virtue of Novartis’ decision-making authority under this Section 5.4 that Enanta reasonably believes would be inconsistent with the scope of the existing, mutually agreed Research Program, materially increase Enanta’s unreimbursed
expenses, cause Enanta to violate the terms of any other Agreement with a Third Party, or cause Enanta to violate any law or intellectual property right of any Third Party. 

 

	5.5	Costs of Governance. The Parties agree that the costs incurred by each Party in connection with its participation at any meetings under this Section 5 shall
be borne solely by such Party. 

  

	5.6	Change of Control. In the event of a Change of Control, Novartis may immediately dissolve the JSC by providing written notice to Enanta; provided that if the
Research Program is still ongoing, the JSC may not be dissolved until the end of the Research Program. 

  

	5.7	Post-JSC Reporting; Query Rights. 

  

	 	(a)	 Upon dissolution of the JSC pursuant to Section 5.3(a), 5.6 or 16.1(c), Novartis shall commence providing progress reports to Enanta at [*****]
month intervals during the Term of this Agreement, the first of which shall be due [*****] months after the last JSC meeting. These reports shall include without limitation: (i) a summary of research activities conducted by Novartis or its
Affiliates with respect to Licensed Compound(s); (ii) a summary of Development activities and plans with respect to Licensed Compound(s) and Product(s); (iii) a summary of Novartis’ Commercialization activities and plans with respect
to the Product(s), 

  

					
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and (iv) a summary of any key issues encountered during Development or Commercialization, including without limitation any issues regarding safety, toxicity, clinical trial delays or
manufacturing concerns. 

  

	 	(b)	Enanta shall also have the right, from time to time, between reports provided under Section 5.7(a) and/or JSC meetings, as reasonably required to prepare for Board
meetings, investor meetings or the like, to inquire of Novartis, through Novartis’ Alliance Manager, whether there have been any significant developments with respect to the Development, manufacture or Commercialization of Products that have
not yet been reported to Enanta pursuant to Section 7.3(e) or otherwise, and Novartis shall promptly and in good faith provide any such information as reasonably requested by Enanta. 

 

	6.	DISCLOSURE OF ENANTA KNOW-HOW AND COOPERATION 

  

	6.1	Disclosure of Enanta Know-How. Within [*****] days after the Effective Date, Enanta will transfer to Novartis copies of its Know-How, data, information and
results related to the Enanta Compounds that are necessary or useful for the Development, manufacture or Commercialization of the Enanta Compounds and Product(s). Following this initial transfer, at the reasonable request of Novartis, Enanta will
provide reasonable assistance to Novartis and its Affiliates in connection with Novartis’ exercise of the licenses and rights granted to Novartis under this Agreement, including by providing information to assist Novartis or its designated
Affiliate in Developing and manufacturing the Licensed Compound(s) and Product(s), and related activities. Without limiting the foregoing, requested information may include, without limitation, manufacturing batch records, Development reports,
analytical results, filings and correspondence with any Regulatory Authority (including notes or minutes of any meetings with any Regulatory Authority), raw material and excipient sourcing information, quality audit findings and any other relevant
technical information relating to the Licensed Compound(s) and/or the Product(s). 

  

	6.2	Compound Transfer. Within [*****] days after the Effective Date, and from time to time during the Term of this Agreement, at the reasonable request of Novartis,
Enanta or its Affiliates, shall provide to Novartis or its designated Affiliate reasonable quantities of any Licensed Compounds in Enanta’s possession for use by Novartis and its Affiliates in connection with activities under this Agreement.
For clarity, except as provided in the Research Plan, Enanta shall not be required to synthesize any new quantities of Licensed Compounds for delivery pursuant to this Section 6.2, and shall be permitted to retain reasonable quantities of
Licensed Compounds for use pursuant to the Research Program or following any termination of Novartis’ rights hereunder. 

  

	6.3	Cooperation. Enanta shall provide cooperation under this Agreement, including without limitation pursuant to Sections 6.1 and 6.2, as reasonably requested by
Novartis. Any reasonable assistance requested during the [*****] day period commencing with the Effective Date shall be provided by Enanta to Novartis and its Affiliates [*****]. Thereafter, any assistance requiring a material expenditure of effort
on the part of Enanta and that is not included as part of the Research Plan shall be provided [*****] commencing with the Effective Date [*****]. 

  

					
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	6.4	Notwithstanding anything in this Agreement to the contrary, (i) in no event will Enanta personnel be required to travel pursuant Articles 6, 7 or 8 of this
Agreement without reimbursement of related expenses by Novartis, and (ii) in no event will Enanta be required to participate in, or conduct any activities related to, the research, development or commercialization of any Product which includes
[*****]. 

  

	7.	DEVELOPMENT 

  

	7.1	Development. From and after the Effective Date Novartis will be solely responsible for conducting the preclinical, clinical and other Development of the
Licensed Compound(s) and/or Product(s), all at Novartis’ sole expense. 

  

	7.2	Development Diligence. Novartis shall itself, or through its Affiliates or sublicensees, use Commercially Reasonable Efforts to Develop Licensed Compounds
and Products in the Field in the Territory. Subject to compliance with the foregoing, the Development of the Product(s) shall be in Novartis’ sole discretion. For the purposes of clarity, Commercially Reasonable Efforts in this context shall
not be deemed to require Novartis to Develop every Licensed Compound or Product in each indication in each country in the Territory. 

  

	7.3	Regulatory. 

  

	 	(a)	Novartis will: (i) determine the regulatory plans and strategies for the Licensed Compound(s) and/or Product(s); (ii) make all regulatory filings with respect
to the Product(s) either itself or through its Affiliates or sublicensees; and (iii) be responsible for obtaining and maintaining Regulatory Approvals throughout the Territory in the name of Novartis and/or its Affiliates and/or its
sublicensees. 

  

	 	(b)	Enanta shall fully cooperate with and provide assistance to Novartis and its Affiliates and sublicensees, at Novartis’ sole expense, in connection with filings to
any Regulatory Authority relating to the Licensed Compound(s) and/or Product(s), including by executing any required documents, providing reasonable access to personnel and providing Novartis and its designated Affiliates with copies of all
relevant, reasonably required documentation, provided that the first [*****]. Any additional regulatory assistance requiring a material expenditure of time or effort on the part of Enanta shall be provided at a reasonable expense rate mutually
agreed by the Parties. 

  

	 	(c)	To the extent required with respect to the Development or Commercialization of Licensed Compounds, Enanta shall grant or cause to be granted to Novartis and its
Affiliates or sublicensees cross-reference rights to any drug master files relevant to Licensed Compounds or Products, and other regulatory filings relevant to Licensed Compounds or Products, submitted by Enanta or its Affiliates with any Regulatory
Authority. 

  

					
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	 	(d)	Subject to Section 14, Novartis and its Affiliates shall have the sole right to disclose the existence of any clinical trials conducted under this Agreement.

  

	 	(e)	Novartis shall keep Enanta’s Alliance Manager reasonably apprised of all material changes in the status of the Product Development programs, including without
limitation by providing at least fifteen (15) days’ prior written notice of the commencement of any new clinical trial of a Product, and by providing prompt notification with respect to any other significant developments with respect to
the Development, manufacture or Commercialization of Products including without limitation any issues regarding Product safety, toxicity, clinical trial delays or manufacturing concerns, or a material delay in any previously communicated Development
or Commercialization plan. 

  

	7.4	Compliance. Each Party agrees that in performing its obligations under this Agreement: (a) it shall comply with all applicable current international
regulatory standards, including cGMP, cGLP, cGCP and other rules, regulations and requirements; and (b) it will not employ or use any person that has been debarred under Section 306(a) or 306(b) of the U.S. Federal Food, Drug and Cosmetic
Act. 

  

	8.	MANUFACTURING 

  

	8.1	Manufacturing. Novartis and its Affiliates or its designated sublicensees shall be solely responsible, at Novartis’ expense, for the manufacture and supply
of the Licensed Compound(s) and Product(s) being Developed or Commercialized under this Agreement. 

  

	8.2	Manufacturing Know-How and Assistance. 

  

	 	(a)	During the Term of this Agreement, Enanta shall fully cooperate with and provide assistance to Novartis or its designee, through documentation, consultation, and
face-to-face meetings, to enable Novartis or its designee, in an efficient and timely manner, to proceed with manufacturing of the Licensed Compound(s) and to obtain all appropriate Regulatory Approvals for manufacturing. Cooperation for
manufacturing assistance shall not be subject to the cap of man hours in Section 6.3. 

  

	 	(b)	Following the Effective Date, the Parties will work together to transfer all ongoing obligations under any existing GMP manufacturing agreements relevant to Licensed
Compounds to Novartis. 

  

	9.	COMMERCIALIZATION 

  

	9.1	 Commercialization. Subject to Article 10, Novartis and its Affiliates shall be solely responsible, at Novartis’ expense, for all aspects of
Commercialization of the Product(s) in the Territory, including planning and implementation, distribution, marketing, booking of sales, pricing and reimbursement. Novartis shall itself, or through its Affiliates or sublicensees, use Commercially
Reasonable Efforts to Commercialize Products in the Field in the Territory. Notwithstanding the foregoing, Novartis’ application of 

  

					
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Commercially Reasonable Efforts shall not require Novartis or its Affiliates to Commercialize a Product in any country or territory in which Novartis reasonably determines it is not commercially
reasonable to do so for such Product(s), including without limitation for reasons of lack of rights to Product components other than Licensed Compounds in such country or territory. 

 

	9.2	Pharmacovigilance. Within [*****] months following the Effective Date, the Parties shall agree upon and implement a procedure for the mutual exchange of adverse
event reports and safety information associated with the Product. Details of the operating procedure respecting such adverse event reports and safety information exchange shall be the subject of a mutually-agreed written pharmacovigilance agreement
between the Parties which shall be entered into within such [*****] month period. 

  

	10.	CO-DETAILING 

  

	10.1	Enanta Co-Detail Right. Enanta shall have the right to Co-Detail Product(s) in the United States in accordance with agreed Commercialization plans and budgets
under certain preconditions as further specified below; provided that in the event of a Change of Control where the Acquirer is a Significant Pharmaceutical Company, Novartis may immediately terminate Enanta’s right to Co-Detail Products by
providing written notice to Enanta. 

  

	10.2	Co-Detail Option. At least [*****] months before the planned submission of an NDA to the FDA for each Product being Developed hereunder to reach such stage,
Novartis will notify Enanta of Novartis’ preliminary estimate of the annual number of Details it anticipates for Products in the United States (the “Co-Detail Notice”) and will provide Enanta with a proposed Commercialization
plan and budget that includes, without limitation, an outline of the anticipated date of initiation of Detailing activities, the expected total number of sales representatives, as well as the anticipated date of First Commercial Sale for the
relevant Product in the United States. In the event that Enanta wishes to Co-Detail any such Product in the United States, it shall provide notice in writing to Novartis of such election no later than [*****] days after its receipt of the Co-Detail
Notice, which notice shall contain the information as further provided in Sections 10.3(a) and (b) (the “Co-Detail Option Exercise Notice”). Prior to giving any such notice, Enanta may request reasonable discussions with
Novartis regarding the expected activities, which the Parties shall conduct in good faith. In the event that Enanta does not respond within the relevant [*****] day period, Enanta shall be deemed to have declined to exercise its rights to Co-Detail
the relevant Product. In the event that Enanta does not elect to Co-Detail the first Product offered to it by Novartis, Enanta shall have the right to elect to Co-Detail the second Product offered to Enanta by Novartis on the same terms as provided
above. In the event that Enanta does not elect to Co-Detail the second Product offered to it by Novartis, then Enanta’s right to Co-Detail any Products hereunder shall terminate. 

  

					
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	10.3	Co-Detail Mechanism. Any Co-Detail Option Exercise Notice provided by Enanta will: 

 

	 	(a)	specify Enanta’s desired level of participation in the Co-Detail of Products in the United States (the “Enanta Co-Detail Effort”);
provided, however, that the Enanta Co-Detail Effort shall not exceed [*****] of the total projected Detailing effort for Products in the United States as specified in the Co-Detail Notice. In the event that Novartis materially increases the
annual number of Details it anticipates for Products in the United States at any time after providing the Co-Detail Notice, then Enanta shall have the right to reduce the Enanta Co-Detail Effort commensurately, but such reduction shall apply to all
Products thereafter and may not later be increased by Enanta. In addition, in no event shall Novartis be required to decrease its sales force with respect to Products as a consequence of Enanta’s exercise of its Co-Detail right following
receipt of the second Co-Detail Notice as provided above; 

  

	 	(b)	be accompanied by reasonably detailed plans demonstrating, to Novartis’ reasonable satisfaction, that Enanta will have in place, at least [*****] before the
earlier of the anticipated First Commercial Sale of such Product in the United States and/or contemplated start of Detailing activities for Products in the United States, as indicated in the Co-Detail Notice, the requisite sales force and sales
force infrastructure required to provide the Enanta Co-Detail Effort as follows: 

  

	 	(i)	Such sales force shall comprise Enanta-employed sales representatives who (A) have a level of experience and/or academic qualifications similar to standards
imposed by Novartis upon its own sales force for a comparable product, which Novartis shall provide to Enanta as part of the Co-Detail Notice; (B) devote not less [*****] and attention to Detailing of Products; and (C) are not engaged in
detailing any product for [*****] that is not a Product; and 

  

	 	(ii)	Such sales force infrastructure shall include (A) a sales force automation system through which sales representatives can record calls electronically, receive
email communications and reports, view sales reports and download specialist targets and lists; (B) a sample accountability system that complies with all applicable laws and regulations; (C) a sales training department; (D) a
department responsible for the design and administration of Enanta sales incentive plan; (E) a voice mail system; (F) a system for sales reporting and analysis; (G) a sales administration and operations department that handles, among
other things, fleet management; (H) a department that establishes and maintains territory alignments consistent with target customer lists provided by Novartis; (I) an electronic roster system that tracks sales force vacancy, turnover,
demographics and territory occupancy; (J) an electronic field expense reporting system; and (K) compliance reporting as required by all applicable laws and regulations. 

 

	 	(c)	 Promptly following receipt of Enanta’s Co-Detail Option Exercise Notice, Novartis and Enanta will commence negotiations in good faith and enter
into a 

  

					
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more detailed co-detailing agreement (the “Co-Detailing Agreement”) pursuant to which: (i) Enanta shall have the non-exclusive right to Co-Detail Products in the United
States in accordance with the terms hereof; and (ii) the Parties will set forth terms and conditions for the Co-Detail by Enanta of Products in the United States, containing reasonable and customary provisions for an agreement of such type. The
Parties shall use commercially reasonable efforts to enter into and execute the Co-Detailing Agreement no later than [*****] days before the expected launch of the first Product for which Enanta has exercised its Co-Detail right. Either Party may
assign such Co-Detailing Agreement or related duties to an Affiliate following prior written notice to the other Party. In the event of a Change of Control involving a Significant Pharmaceutical Company, Novartis may immediately terminate the
Co-Detailing Agreement by providing written notice to Enanta. 

  

	 	(d)	Enanta’s Co-Detail activities hereunder and under the Co-Detailing Agreement shall be conducted in accordance with the Commercialization plan (including a
Commercialization budget) for the relevant Product, which shall be reasonably consistent with the Co-Detail Notice, unless otherwise mutually agreed. 

  

	 	(e)	For clarity, regardless of Enanta’s decision to Co-Detail, Novartis shall retain all decision-making authority related to Product branding, marketing plan,
advertising, materials, regulatory and legal affairs, and pricing and commercial terms and all other aspects of Commercializing the Products in the United States. 

 

	 	(f)	Enanta’s costs of performing Co-Detailing activities will be reimbursed by Novartis on an [*****] basis at an [*****] for such detailing activities (such [*****]
to be negotiated as part of the Co-Detailing Agreement). Enanta shall not be entitled to any other compensation for performing Co-Detailing activities unless agreed by the Parties in writing. 

 

	 	(g)	Once the Parties have entered into a Co-Detailing Agreement, Enanta shall be required to Co-Detail all Products in accordance with the terms of such Co-Detailing
Agreement. The Parties acknowledge and agree that such Co-Detailing Agreement shall be a separate agreement between the Parties and that a breach of any such agreement that is not a breach of the other sections of this Agreement shall not give rise
to a right to terminate this Agreement. For clarity, Enanta shall not be required to Co-Detail, or to continue to Co-Detail, any Product to the extent such activities would violate the terms of any agreement between Enanta and a Third Party.

  

	11.	FINANCIAL PROVISIONS 

  

	11.1	 Upfront Payment; Reimbursement for Manufacture of EDP-239 Intermediates and QA Audit Expense. In consideration of the licenses and rights
granted to Novartis and its Affiliates hereunder, Novartis shall pay to Enanta a one-time upfront payment of $34 million within thirty (30) days after the Effective Date, subject to receipt by Novartis of

  

					
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an Invoice therefor, which Invoice shall be issued no earlier than the Effective Date. In addition, Novartis shall pay to Enanta: (i) [*****] as a reimbursement for Enanta’s
manufacturing expenses related to EDP-239 intermediates; and (ii) up to [*****] as a reimbursement for the expenses [*****]. Novartis shall pay such amounts within [*****] days after the Effective Date, subject to receipt by Novartis of an
Invoice therefor, which Invoice shall be issued no earlier than the Effective Date. 

  

	11.2	Milestone Payments. In further consideration of the licenses and rights granted to Novartis hereunder, upon first achievement of each of the following Milestones
set forth below by any Product (or group of Products as provided below with respect to Sales Milestones), the corresponding one-time Milestone Payments shall be due and payable by Novartis to Enanta. Payment shall be made as provided in
Section 12.1. 

  

	 	(a)	Clinical Milestones 

  

			
	 Milestone Event
	  	Milestone Payment
		
	 FPFV in the first Phase I Clinical Trial for a Product
	  	$11 million
		
	 FPFV in the first Phase II Clinical Trial for a Combination Product involving patients infected with the Hepatitis C
virus
	  	$15 million
		
	 FPFV in the first Phase III Clinical Trial for a Product
	  	[*****]

  

	 	(b)	Regulatory Approval Milestones 

  

			
	 Milestone Event
	  	Milestone Payment
		
	 First Regulatory Approval for a Product in the [*****]
	  	[*****]
		
	 First Regulatory Approval for a Product in the [*****]
	  	[*****]
		
	 First Regulatory Approval for a Product in the [*****]
	  	[*****]
		
	 First Regulatory Approval for a Product in the [*****]
	  	[*****]
		
	 First Regulatory Approval for a Product in [*****]
	  	[*****]
		
	 First Regulatory Approval for a Product in [*****]
	  	[*****]

  

					
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	 	(c)	Sales Milestones (note: Product as used in this subsection (c) includes any and all Products which contain a particular Licensed Compound):

  

			
	 Milestone Event
	  	Milestone Payment
		
	 Annual Net Sales of a Product meets or exceeds [*****]
	  	[*****]
		
	 Annual Net Sales of a Product meets or exceeds [*****]
	  	[*****]
		
	 Annual Net Sales of a Product meets or exceeds [*****]
	  	[*****]
		
	 Annual Net Sales of a Product meets or exceeds [*****]
	  	[*****]

  

	 	(d)	If a subsequent Clinical Milestone is achieved with respect to a Product before one or more prior Clinical Milestones (e.g., if the first FPFV in the first Phase III
Clinical Trial for the first Product occurs prior to FPFV in the first Phase II Clinical Trial in HCV for the first Combination Product), then all prior “missed” Clinical Milestones shall be deemed achieved with respect to such Product
upon achievement of the subsequent Clinical Milestone and the corresponding missed Milestone Payment(s) shall become due and payable. 

  

	 	(e)	For the avoidance of doubt: (i) each Milestone Payment shall be payable only on the first occurrence of the relevant Milestone; and (ii) none of the Milestone
Payments shall be payable more than once. 

  

	11.3	Incremental Royalty Payments. 

  

	 	(a)	In further consideration of the licenses and rights to Novartis hereunder, during the applicable Royalty Term, Novartis will make royalty payments to Enanta on Net
Sales of the applicable Products in the Territory by Novartis, its Affiliates and sublicensees at the applicable rates set forth below, where Product as used in this subsection (a) only (and not any other subsection of this Section 11.3)
includes any and all Products which contain a particular Licensed Compound: 

  

			
	 Annual Net Sales of Product during the Royalty Term
	  	Royalty Rate
		
	 Up to and including [*****]
	  	[*****]
		
	 Increment from [*****]
	  	[*****]
		
	 Increment from [*****]
	  	[*****]
		
	 Increment over [*****]
	  	[*****]

  

					
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	 	(b)	Royalties will be payable on a Product-by-Product and country-by-country basis from First Commercial Sale of such Product in such country until the later of:
(i) the expiration of the last to expire Valid Claim which, but for the licenses granted in this Agreement, would be infringed by the manufacture, use or sale of such Product in such country; and (ii) ten (10) years from the First
Commercial Sale of such Product in such country (“Royalty Term”). Following the Royalty Term on a Product-by-Product and country-by-country basis, the licenses granted to Novartis and its Affiliates under Section 3.1 with
respect to such Product(s) shall continue in effect, but shall become fully paid-up, non-exclusive, royalty-free, transferable, perpetual and irrevocable. For the avoidance of doubt, royalties shall be payable only once with respect to the same unit
of Product. 

  

	11.4	Know-How Royalty. For any period during the Royalty Term in which the sale of a Product in any country is not covered by a Valid Claim which, but for the
licenses granted in this Agreement, would be infringed by the manufacture, use or sale of such Product in such country, then the royalty rates applicable to Net Sales of such Product in such country during such period shall be reduced by [*****],
according to the methodology provided in Section 11.5 below. 

  

	11.5	Royalty Example. If, by way of example, Net Sales of a given Product in the Territory in a given Calendar Year are [*****], with Net Sales distributed across
countries as follows: (a) [*****] Net Sales in countries in which there is a Valid Claim; (b) [*****] Net Sales in countries where the manufacture, use or sale of the Product is not covered by a Valid Claim; and (c) [*****] Net Sales
in countries where the Royalty Term for such country has expired; then royalties due under Sections 11.3 and 11.4 for such Product in such Calendar Year shall be calculated as follows: Net Sales on which royalties are due shall be [*****] (=
(a) + (b)). The royalty rate applicable under Section 11.3 shall be calculated as [*****]. The royalties due for (a) above shall be calculated as [*****]. No royalties shall be due with regard to (c) above. Total royalties due
under Sections 11.3 and 11.4 shall be equal to [*****], subject to further reductions, if any, under Sections 11.6 and 11.7. 

  

	11.6	Loss of Market Exclusivity. In the event of a Loss of Market Exclusivity for any Product in any country, provided that Novartis has taken and is taking all
commercially reasonable actions available to it to enforce any Patent Rights it may own or control that could prevent relevant sales of a Generic Equivalent in such country, then the royalty rates applicable to Net Sales of such Product in such
country in accordance with Section 11.3 shall be reduced by [*****] as follows: for such purposes, the reduction will be calculated assuming that the royalty rate in such country is the Blended Rate for such Product (i.e., the reduced royalty
rate for such country shall be [*****] of the Blended Rate). Such reduction shall be first applied with respect to such country starting with sales in the Calendar Quarter following the Calendar Quarter in which Loss of Marketing Exclusivity occurs
for such Product in such country. 

  

					
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	11.7	Third Party Obligations. 

  

	 	(a)	Notwithstanding the provisions of this Section 11.7, Enanta shall remain responsible for the payment of royalty, milestone and other payment obligations, if any,
due to Third Parties under any Enanta Patents or Enanta Know-How which have been licensed to Enanta and are sub-licensed to Novartis under this Agreement. All such payments shall be made promptly by Enanta in accordance with the terms of its license
agreement. 

  

	 	(b)	In the event that Novartis reasonably determines that rights to intellectual property owned or Controlled by a Third Party claiming the structure of any Licensed
Compound are required in order to avoid infringement of such Third Party’s rights, Novartis shall have the right to negotiate and acquire such rights through a license or otherwise. Novartis shall be entitled to deduct from the payments due to
Enanta under Sections 11.2 and 11.3 with respect to the relevant Licensed Compound or Product [*****] of the amounts paid (whether in the form of [*****]) by Novartis to such Third Party; provided, however, that in no event shall the amounts due to
Enanta from Novartis with respect to the relevant Product be reduced through this subsection 11.7(b) by more than [*****] of the amounts otherwise due for such Product in any Calendar Quarter. Any amount that Novartis is entitled to deduct that is
reduced by the above-recited limitation on the deduction shall be carried forward and Novartis may deduct such amount from subsequent payments due to Enanta with respect to the relevant Product until the full amount that Novartis was entitled to
deduct is deducted. 

  

	 	(c)	In the event that Novartis reasonably determines that it would be useful to acquire rights to intellectual property owned or Controlled by a Third Party, which
intellectual property rights do not pertain (i) to the structure of any Licensed Compound or (ii) to the structure of any other active ingredient in a Product or the formulation of only such other active ingredient, in order to Develop,
manufacture, Commercialize or sell a Product, Novartis shall have the right to negotiate and acquire such rights through a license or otherwise. Novartis shall be entitled to deduct from the payments due to Enanta under Section 11.3 with
respect to the relevant Licensed Compound or Product [*****] of the amounts paid (whether in the form of [*****]) by Novartis to such Third Party; provided, however, that in no event shall the [*****] due to Enanta from Novartis with respect to the
relevant Product be reduced through this subsection 11.7(c) by more than [*****] of the royalty amounts otherwise due for such Product in any Calendar Quarter; and provided further that, with respect to intellectual property relevant to more than
one active ingredient of a Combination Product, any such deductions shall be reasonably apportioned between or among the applicable components of the Combination Product. Any amount that Novartis is entitled to deduct that is reduced by the
above-recited limitation on the deduction shall be carried forward and Novartis may deduct such amount from subsequent [*****] due to Enanta with respect to the relevant Product until the full amount that Novartis was entitled to deduct is deducted.

  

					
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	11.8	Royalty Floor. Except in connection with a termination by Novartis pursuant to Section 15.2(b), in no event shall the total royalty payable to Enanta for
any Product in any country in any Calendar Quarter after giving effect to all applicable reductions set forth herein, be reduced to less than [*****] of the rate specified in Section 11.3(a) for sales of a given Product in any given country.

  

	11.9	Research Funding. Enanta shall support the Research Program with [*****] Enanta FTEs during each year of the Research Term, as further specified in the agreed
Research Plan. Novartis shall pay Enanta quarterly in arrears for such FTEs at the FTE Rate within [*****] days after receipt of an Invoice therefor. Any pre-approved out-of pocket expenses shall be invoiced for reimbursement along with any such
FTEs. 

  

	11.10	No Projections. Enanta and Novartis acknowledge and agree that nothing in this Agreement shall be construed as representing an estimate or projection of
anticipated sales of any Product, and that the Milestones and Net Sales levels set forth above or elsewhere in this Agreement or that have otherwise been discussed by the Parties are merely intended to define the Milestone Payments and royalty
obligations to Enanta in the event such Milestones or Net Sales levels are achieved. NEITHER ENANTA NOR NOVARTIS MAKES ANY REPRESENTATION OR WARRANTY, EITHER EXPRESS OR IMPLIED, THAT IT WILL BE ABLE TO SUCCESSFULLY COMMERCIALIZE ANY PRODUCT OR, IF
COMMERCIALIZED, THAT ANY PARTICULAR NET SALES LEVEL OF SUCH PRODUCT WILL BE ACHIEVED. 

  

	12.	REPORTS AND PAYMENT TERMS 

  

	12.1	Payment Terms. 

  

	 	(a)	Novartis shall provide Enanta with written notice of the achievement of each Milestone within [*****] days after such Milestone has been achieved. After receipt of such
notice (if applicable), Enanta shall submit an Invoice to Novartis with respect to the corresponding Milestone Payment. Novartis shall pay such Milestone Payment within [*****] days after receipt of such Invoice. 

 

	 	(b)	Within [*****] days after each Calendar Quarter during the Term of this Agreement following the First Commercial Sale of a Product, Novartis will provide to Enanta a
Sales and Royalty Report. Enanta shall submit an Invoice with respect to the royalty amount shown therein. Novartis shall pay such royalty amount within [*****] days after receipt of the Invoice. 

 

	 	(c)	All payments from Novartis to Enanta shall be made by wire transfer in United States Dollars to the credit of such bank account as may be designated by Enanta in this
Agreement or in writing to Novartis. Any payment which falls due on a date which is not a Business Day in Cambridge, Massachusetts or Basel, Switzerland may be made on the next succeeding Business Day in Cambridge, Massachusetts or Basel,
Switzerland. 

  

					
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	12.2	Currency. All payments under this Agreement shall be payable in United States Dollars. When conversion of payments from any foreign currency is required to be
undertaken by Novartis, the United States Dollar equivalent shall be calculated using Novartis’ then-current standard exchange rate methodology applied in its external reporting for the conversion of foreign currency sales into United States
Dollars. Upon request by Enanta, Novartis shall provide Enanta with information on Novartis’ then-current currency exchange policy. 

  

	12.3	Taxes. Enanta will pay any and all taxes levied on account of any payments made to it under this Agreement. If any taxes are required to be withheld by Novartis,
Novartis will: (a) deduct such taxes from the payment made to Enanta; (b) timely pay the taxes to the proper taxing authority; (c) send proof of payment to Enanta; and (d) reasonably assist Enanta in its efforts to obtain a
credit for such tax payment. Each Party agrees to reasonably assist the other Party in lawfully claiming exemptions from and/or minimizing such deductions or withholdings under double taxation laws or similar circumstances. 

 

	12.4	Interest Due. Without limiting any other rights or remedies available to Enanta, Novartis shall pay Enanta interest on any late payments made under this
Agreement, whether late due to late payment of an Invoice or due to late notification to Enanta of the corresponding event or report giving rise to the Invoice pursuant to Section 12.1, at a rate per annum equal to the lesser of the [*****]
month [*****] or [*****], calculated on the total number of days payment is late. 

  

	12.5	Records and Audit Rights. 

  

	 	(a)	Each Party shall keep complete, true and accurate books and records in accordance with its Accounting Standards in relation to this Agreement, including, with respect
to Novartis and its Affiliates, in relation to Net Sales and royalties, and with respect to Enanta, in relation to FTE efforts expended under the Research Program. Novartis and its Affiliates shall require any sublicensees to keep (all in accordance
with generally accepted accounting principles, consistently applied), complete and accurate records in sufficient detail to properly reflect relevant Net Sales and to enable the royalties payable hereunder to be determined. Each Party or other
selling entity will keep such books and records for at least three (3) years following the Calendar Year to which they pertain. 

  

	 	(b)	 Enanta may upon written request, cause an internationally-recognized independent accounting firm (the “Auditor”) which is reasonably
acceptable to Novartis to inspect the relevant records of Novartis and its Affiliates to verify the royalties payable by Novartis and the related reports, statements, records and books of accounts, as applicable. Novartis may upon written request,
cause an Auditor that is reasonably acceptable to Enanta to inspect the relevant records of Enanta and its Affiliates as reasonably required to verify the amounts payable by Novartis hereunder or Enanta’s required FTE support or reimbursable
expenses, as applicable. Before beginning its audit, the Auditor shall execute an undertaking 

  

					
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acceptable to Party being audited by which the Auditor agrees to keep confidential all information reviewed during the audit. The Auditor shall have the right to disclose to the auditing Party
only its conclusions regarding any payments owed under this Agreement. 

  

	 	(c)	Each Party and its Affiliates shall make their records available for inspection by the Auditor during regular business hours at such place or places where such records
are customarily kept, upon receipt of reasonable advance notice from the other Party. The records shall be reviewed solely to verify the accuracy of payments hereunder and compliance with this Agreement. Such inspection right shall not be exercised
more than once in any calendar year and not more frequently than once with respect to records covering any specific period of time. In addition, the auditing Party agrees to hold in strict confidence all information received and all information
learned in the course of any audit or inspection, except to the extent necessary to enforce its rights under this Agreement or to the extent required to comply with any law, regulation or judicial order. 

 

	 	(d)	The Auditor shall provide its audit report and basis for any determination to the audited Party at the time such report is provided to the auditing Party before it is
considered final. 

  

	 	(e)	In the event that the final result of any such inspection reveals an undisputed underpayment or overpayment, the underpaid or overpaid amount shall be settled promptly.

  

	 	(f)	The auditing Party shall pay for such audits, as well as its expenses associated with enforcing its rights with respect to any payments hereunder. In addition, if an
underpayment (with respect to royalties) or overpayment (with respect to research-related payments to Enanta) of more than ten percent (10%) of the total payments due hereunder for the applicable calendar year is discovered, the fees and
expenses charged by the Auditor shall be paid by the audited Party. 

  

	 	(g)	To the extent applicable, Novartis and its Affiliates shall include in each sublicense granted by it to any sublicensee a provision requiring the sublicensee to
maintain records of sales made pursuant to such license and to grant access to such records by Novartis’ designated independent accountant to the same extent and under the same obligations as required of Novartis under this Agreement. Enanta
shall have the right to request audits of sublicensees by Novartis for reasonable cause. Novartis shall advise Enanta in advance of each audit of any sublicensee with respect to Product sales. Novartis will provide Enanta with a summary of the
results received from the audit and, if Enanta so requests, a copy of the audit report with respect to Product sales. Novartis shall pay for any such audits of sublicensees, provided that Enanta will pay for any such audits of sublicensees that are
expressly requested by Enanta in writing. Notwithstanding the foregoing, if an underpayment of more than [*****] is discovered, the fees and expenses charged by the Auditor shall be paid by Novartis, unless otherwise borne by the sublicensee.

  

					
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	13.	INTELLECTUAL PROPERTY RIGHTS 

  

	13.1	Ownership of Inventions. 

  

	 	(a)	All Know-How arising from the Parties’ activities under this Agreement, and any patent applications and patents covering inventions therein, made solely by
employees or consultants of a Party shall be solely owned by such Party. All Know-How arising from the Parties’ activities under this Agreement, and any patent applications and patents covering inventions therein, made jointly by employees or
consultants of both Parties shall be owned jointly by the Parties. Determination of inventorship shall be made in accordance with United States patent laws. 

 

	 	(b)	Enanta’s rights in any such Know-How and Patent Rights which are Enanta Patents, Enanta Know-How or Collaboration IP, as appropriate, will be exclusively licensed
to Novartis as provided in Section 3.1. Subject to the foregoing, each Party may use, or license to any Third Party, any jointly owned Know-How and Patent Rights for any purpose consistent with the provisions of this Agreement without
accounting to or obtaining the approval of the other Party. However, neither Party shall assign to any Third Party its interest in any jointly owned Patent Rights without the other Party’s prior written consent (not to be unreasonably
withheld), except to the extent permitted in Section 20.1. 

  

	13.2	Patent Prosecution. 

  

	 	(a)	Novartis shall, in consultation with Enanta, be responsible for filing, prosecuting and maintaining the Enanta IP (in the name of Enanta) and Collaboration IP (in the
name(s) of the owner(s) thereof as determined in accordance with Section 13.1(a)) at Novartis’ own cost and expense. Novartis shall use Commercially Reasonable Efforts to obtain appropriate patent protection with respect to claimed
inventions that are supported by the relevant specification, whether or not relevant to Products being actually Developed or Commercialized by Novartis hereunder. Enanta shall fully cooperate with Novartis in connection with the filing, prosecution
and maintenance of the Enanta IP and the Collaboration IP to the extent reasonably requested by Novartis, including by providing access to relevant persons and executing all documentation reasonably requested by Novartis. Novartis shall consult with
Enanta and keep Enanta reasonably informed of the status of such Enanta IP and Collaboration IP, and provide copies of all relevant documents in a timely manner for Enanta’s review and comment, including any material reduction in scope, and
will reasonably consider any Enanta comments in good faith, it being understood and agreed, however, that Novartis shall have the authority to make, in good faith, all final decisions relating thereto. 

  

					
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	 	(b)	Novartis will notify Enanta of any decision not to file applications for, or to cease prosecution and/or maintenance of, or not to continue to pay the expenses of
prosecution and/or maintenance of, any Enanta IP and Collaboration IP, including without limitation any decision to abandon any pending or issued claim in the Enanta IP or Collaboration IP. Novartis will provide such notice at least thirty (30)
days prior to any relevant filing or payment due date, or any other due date that requires action, in connection with such Patent Right and/or claim. In such event, Novartis shall permit Enanta, at its sole discretion and expense, to file or to
continue prosecution or maintenance of such Enanta IP or Collaboration IP, Novartis shall fully cooperate with Enanta in connection with the filing, prosecution and maintenance of the Enanta IP and the Collaboration IP to the extent reasonably
requested by Enanta, including by providing access to relevant persons and executing all documentation reasonably requested by Enanta. 

  

	13.3	Patent Infringement. 

  

	 	(a)	Each Party will promptly notify the other of any infringement by a Third Party of any of the Enanta IP or Collaboration IP of which it becomes aware, including any
“patent certification” filed in the United States under 21 U.S.C. §355(b)(2) or 21 U.S.C. §355(j)(2) or similar provisions in other jurisdictions and of any declaratory judgment, opposition, or similar action alleging the
invalidity, unenforceability or non-infringement (collectively “Third Party Infringement”). 

  

	 	(b)	To the extent reasonably related to any exclusive license granted to Novartis under this Agreement, Novartis will have the first right to bring and control any legal
action in connection with the Third Party Infringement at its own expense as it reasonably determines appropriate, and Enanta shall have the right, at its own expense, to be represented in any such action by counsel of its own choice. If Novartis
fails to bring an action or proceeding with respect to, or to otherwise terminate, any such infringement of any Enanta IP or Collaboration IP: (i) within one hundred twenty (120) days following the notice of alleged infringement; or
(ii) prior to twenty (20) days before the time limit, if any, set forth in the appropriate laws and regulations for the filing of such actions, whichever comes first, Enanta shall have the right, but not the obligation, upon written
approval of Novartis (such approval not to be unreasonably withheld or delayed), to bring and control any such action at its own expense and by counsel of its own choice, and Novartis shall have the right, at its own expense, to be represented in
any such action by counsel of its own choice; provided, however, that if Novartis notifies Enanta in writing prior to ten (10) days before such time limit for the filing of any such action that Novartis intends to file such action before the
time limit, then Novartis shall be obligated to file such action before the time limit, and Enanta will not have the right to bring and control such action. 

 

	 	(c)	At the request and expense of the Party prosecuting the relevant action pursuant to Section 13.3(b), the other Party shall provide reasonable assistance in
connection therewith, including by executing reasonably appropriate documents, cooperating in discovery and joining as a party to the action if required. 

  

					
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	 	(d)	In connection with any proceeding pursuant to Section 13.3(b), Novartis shall not enter into any settlement admitting the invalidity of, or otherwise impairing
Enanta’s rights in, the Enanta IP or the Collaboration IP without the prior written consent of Enanta, which will not be unreasonably withheld or delayed. 

 

	 	(e)	Any recoveries resulting from such an action relating to a claim of Third Party Infringement subject to Section 13.3(b) shall be first applied against payment of
each Party’s costs and expenses in connection therewith. In the event that Novartis brought such action, any remainder will be retained by (or if received by Enanta, paid to) Novartis; provided, however, that any portion of such remainder that
is attributable to lost profits with respect to the Product shall be subject to a royalty payment to Enanta of [*****]. In the event that Enanta brought any such action, any remainder shall be divided equally between Enanta and Novartis.

  

	13.4	Trademarks. Novartis shall have the right to brand the Products using Novartis related trademarks and any other trademarks and trade names it determines
appropriate for the Product, which may vary by country or within a country (“Product Marks”). Novartis shall own all rights in the Product Marks and register and maintain the Product Marks in the countries and regions it determines
reasonably necessary. 

  

	13.5	Patent Marking. To the extent commercially feasible and consistent with prevailing business and legal practices, Novartis shall mark, and shall cause its
Affiliates and sublicensees to mark, all Products that are manufactured or sold under this Agreement with the number of each issued patent owned or controlled by Enanta that applies to such Products. 

 

	13.6	Data Exclusivity and Orange Book Listings. With respect to data exclusivity periods (such as those periods listed in the FDA’s Orange Book (including
without limitation any available pediatric extensions) or periods under national implementations of Article 11.1(a)(iii) of Directive 2001/EC/83, or similar periods as may be applicable to a biologic or drug, and all international equivalents),
Novartis shall use commercially reasonable efforts consistent with its obligations under applicable law (including any applicable consent order) to seek, maintain and enforce all such data exclusivity periods available for the Products exclusively
licensed by Novartis hereunder. With respect to filings in the FDA Orange Book or other similar filings or listings as may be applicable to a biologic or drug (and foreign equivalents) for issued patents for a Product, upon request by Novartis,
Enanta shall provide reasonable cooperation to Novartis in filing and maintaining any such listing and filings. 

  

	13.7	Patent Extensions. 

  

	 	(a)	 If requested by Novartis, Enanta shall cooperate in obtaining patent term restoration (under but not limited to Drug Price Competition and Patent Term
Restoration Act), supplemental protection certificates or their equivalents, and 

  

					
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patent term extensions with respect to the Enanta Patents in any country and/or region where applicable. Enanta shall provide all reasonable assistance requested by Novartis, including permitting
Novartis to proceed with applications for such in the name of Enanta, if deemed appropriate by Novartis, and executing documents and providing any relevant information to Novartis. 

 

	 	(b)	If elections with respect to obtaining any such patent term extensions are to be made, Novartis shall have the right to make the election to seek patent term extension,
restoration or supplemental protection, provided that such election shall be made in accordance with industry norms. 

  

	14.	CONFIDENTIALITY 

  

	14.1	Duty of Confidence. 

Subject to the other provisions of this Section 14, all Confidential Information disclosed by a Party or its Affiliates under this
Agreement will be maintained in confidence and otherwise safeguarded by the recipient Party. The recipient Party may only use Confidential Information of the other Party for the purposes of this Agreement and pursuant to the rights granted to the
recipient Party under this Agreement. Subject to the other provisions of this Section 14, each Party shall hold as confidential such Confidential Information of the other Party or its Affiliates in the same manner and with the same protection
as such recipient Party maintains its own confidential information. Subject to the other provisions of this Section 14, a recipient Party may only disclose Confidential Information of the other Party to employees, agents, contractors,
consultants and advisers of the Party and its Affiliates and sublicensees and to Third Parties to the extent reasonably necessary for the purposes of, and for those matters undertaken pursuant to, this Agreement; and provided that such Persons are
bound to maintain the confidentiality of the Confidential Information in a manner consistent with the confidentiality provisions of this Agreement. 
  

	14.2	Exceptions. The obligations under this Section 14 shall not apply to any information to the extent the recipient Party can demonstrate by competent evidence
that such information: 

  

	 	(a)	is (at the time of disclosure) or becomes (after the time of disclosure) known to the public or part of the public domain through no breach of this Agreement or either
Prior CDA by the recipient Party or its Affiliates; 

  

	 	(b)	was known to, or was otherwise in the possession of, the recipient Party or its Affiliates prior to the time of disclosure by the disclosing Party or any of its
Affiliates; 

  

	 	(c)	is disclosed to the recipient Party or an Affiliate on a non-confidential basis by a Third Party lawfully in possession thereof who is entitled to disclose it without
breaching any confidentiality obligation to the disclosing Party or any of its Affiliates; or 

  

					
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	 	(d)	is independently developed by or on behalf of the recipient Party or its Affiliates, as evidenced by its written records, without reference to the Confidential
Information disclosed by the disclosing Party or its Affiliates under this Agreement. 

  

	14.3	Authorized Disclosures. In addition to disclosures allowed under Section 14.2, to the extent (and only to the extent) that it is reasonably necessary or
appropriate to fulfill its obligations or exercise its rights under this Agreement, the recipient Party may disclose Confidential Information belonging to the disclosing Party in the following instances: 

 

	 	(a)	filing or prosecuting Patent Rights as permitted by this Agreement; 

  

	 	(b)	in connection with Regulatory Filings for Products made pursuant to this Agreement; 

 

	 	(c)	prosecuting or defending litigation as permitted by this Agreement; 

  

	 	(d)	subject to Sections 14.4 and 14.5, complying with applicable governmental laws and regulations (including, without limitation, the rules and regulations of the
Securities and Exchange Commission or any national securities exchange) and with judicial process, if in the reasonable opinion of the recipient Party’s counsel, such disclosure is necessary for such compliance; and 

 

	 	(e)	disclosure, in connection with the performance of this Agreement and solely on a need-to-know basis, to: Affiliates; potential sublicensees; or employees, independent
contractors (including without limitation consultants and clinical investigators) or agents, each of whom prior to disclosure must be bound by written obligations of confidentiality and non-use no less restrictive than the obligations set forth in
this Section 14; provided, however, that the recipient Party shall remain responsible for any failure by any Person who receives Confidential Information pursuant to this Section 14 to treat such Confidential Information as required under
this Section 14. 

  

	 	(f)	If and whenever any Confidential Information is disclosed in accordance with this Section 14.3, such disclosure shall not cause any such information to cease to be
Confidential Information except to the extent that such permitted disclosure results in a public disclosure of such information (otherwise than by breach of this Agreement). Where reasonably possible and subject to Sections 14.4 and 14.5, the
recipient Party shall notify the disclosing Party of the recipient Party’s intent to make such disclosure pursuant to paragraphs (a) through (d) of this Section 14.3 sufficiently prior to making such disclosure so as to allow the
Disclosing Party adequate time to take whatever action it may deem appropriate to protect the confidentiality of the information. 

  

	14.4	 Required Disclosure. A recipient Party may disclose Confidential Information pursuant to interrogatories, requests for information or documents,
subpoena, civil investigative demand issued by a court or governmental agency or as otherwise required by law; 

  

					
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provided however, that the recipient Party shall notify the disclosing Party promptly upon receipt thereof, giving (where practicable) the disclosing Party sufficient advance notice to permit it
to oppose, limit or seek confidential treatment for such disclosure, and to file for patent protection if relevant; and provided, further, that the recipient Party shall furnish only that portion of the Confidential Information which it is advised
by counsel is legally required whether or not a protective order or other similar order is obtained by the disclosing Party. 

  

	14.5	Securities Filings. In the event either Party proposes to file with the Securities and Exchange Commission or the securities regulators of any state or other
jurisdiction a registration statement or any other disclosure document which describes or refers to this Agreement under the Securities Act of 1933, as amended, the Securities Exchange Act, of 1934, as amended, or any other applicable securities
law, the Party shall notify the other Party of such intention and shall provide such other Party with a copy of relevant portions of the proposed filing not less than five (5) business days prior to such filing (and any revisions to such
portions of the proposed filing a reasonable time prior to the filing thereof), including any exhibits thereto relating to the Agreement, and shall use reasonable efforts to obtain confidential treatment of any information concerning the Agreement
that such other Party requests be kept confidential, and shall only disclose Confidential Information which it is advised by counsel is legally required to be disclosed. No such notice shall be required under this Section 14.5 if the substance
of the description of or reference to this Agreement contained in the proposed filing has been included in any previous filing made by the either Party hereunder or otherwise approved by the other Party. 

 

	14.6	Terms of Agreement. The existence and the terms and conditions of this Agreement that the Parties have not specifically agreed to disclose pursuant to
Section 14.5 or Section 19 shall be considered Confidential Information of both Parties. Either Party may disclose such terms on a need-to-know basis to a bona fide investor (provided that such investor is not, and is not affiliated
with, a pharmaceutical company), investment banker, and their attorneys and agents, provided that each such Person to whom such information is to be disclosed is informed of the confidential nature of such information and has entered into a written
agreement with the Party, or is otherwise bound by professional rules, requiring such Person to keep such information confidential. Promptly after the Effective Date, the Parties shall agree upon a redacted form of this Agreement, the relevant
provisions of which may be disclosed on a need-to-know basis to potential licensees, acquirers or merger partners and their attorneys and agents, provided that each such Person to whom such information is to be disclosed is informed of the
confidential nature of such information and has entered into a written agreement with the Party, or is otherwise bound by professional rules, requiring such Person to keep such information confidential. 

 

	14.7	Ongoing Obligation for Confidentiality. Upon early termination of this Agreement for any reason, each Party and its Affiliates shall immediately return to the
other Party or destroy any Confidential Information disclosed by the other Party, except for one copy which may be retained in its confidential files for archive purposes. 

  

					
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	15.	TERM AND TERMINATION 

  

	15.1	Term. The term of this Agreement will commence upon the Effective Date and continue until the expiration of all royalty payment obligations of Novartis
hereunder, unless earlier terminated as permitted by this Agreement (the “Term”). 

  

	15.2	Termination for Cause. 

  

	 	(a)	Termination by Enanta for Cause. If Novartis is in material breach of any material obligation hereunder (other than with respect to a breach of Novartis’
obligations under Sections 7.2 or 9.1 with respect to any given Product, which is governed by Section 15.4), Enanta may give written notice to Novartis specifying the claimed particulars of such breach, and in the event such material breach is
not cured within the relevant time period specified below after such notice, Enanta shall have the right thereafter to terminate this Agreement immediately by giving written notice to Novartis to such effect. Novartis shall have [*****] days to
either cure such breach (except to the extent such breach involves the failure to make a payment when due, which breach must be cured within [*****] days following such notice) or, if cure cannot be reasonably effected within such [*****] day
period, to deliver to Enanta a plan for curing such breach which is reasonably sufficient to effect a cure within a reasonable period not to exceed [*****] days. Following delivery of such plan, Novartis shall use commercially reasonable efforts to
carry out the plan and cure the breach. Any termination by Enanta under this Section and the effects of termination provided herein shall be without prejudice to any damages or other legal or equitable remedies to which it may be entitled from
Novartis. 

  

	 	(b)	 Partial Termination by Novartis for Cause. If Enanta is in material breach of any material obligation hereunder, Novartis may give written
notice to Enanta specifying the claimed particulars of such breach and its desire to partially terminate certain aspects of this Agreement as provided in Section 16.1. In the event that Enanta does not dispute the existence or materiality of an
alleged breach specified in such notice and such material breach is not cured following such notice as provided below, Novartis shall have the right thereafter to terminate certain aspects of this Agreement immediately as provided in
Section 16.1 by giving written notice to Enanta to such effect. Enanta shall have [*****] days to either cure any such breach or, if cure cannot be reasonably effected within such [*****] day period, to deliver to Novartis a plan for curing
such breach which is reasonably sufficient to effect a cure within a reasonable period not to exceed [*****] days. Following delivery of such plan, Enanta shall use commercially reasonable efforts to carry out the plan and cure the breach. If Enanta
disputes in good faith the existence or materiality of an alleged breach and provides notice to Novartis of such dispute within the first [*****] days of the [*****] day notice period specified above, Novartis shall not have the right to implement
the payment reduction set forth in Section 16.1(b) unless and until the existence of such material breach or failure by Enanta has been confirmed in 

  

					
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accordance with Section 20.5, and Enanta has failed to cure such breach within [*****] days following such confirmation. It is understood and acknowledged that during the pendency of any
such dispute as to the existence or materiality of an alleged breach, all of the terms and conditions of this Agreement shall remain in effect and the Parties shall continue to perform all of their respective obligations hereunder; provided that
Novartis shall place into a mutually agreed escrow account [*****] which become due during the pendency of such proceedings. In the event that the existence of such material breach or failure by Enanta is confirmed in accordance with
Section 20.5, and Enanta fails to cure such breach as provided above following such confirmation, then Novartis shall be entitled to receive [*****]. In the event that the existence of such material breach or failure by Enanta is not confirmed
in accordance with Section 20.5, or if Enanta cures such breach as provided above, then Enanta shall be entitled to receive the amounts in escrow. Any termination by Novartis under this Section and the effects of termination provided herein
shall be without prejudice to any damages or other legal or equitable remedies to which it may be entitled from Enanta. 

  

	 	(c)	Full Termination by Novartis for Cause. If Enanta is in material breach of any material obligation hereunder, Novartis may give written notice to Enanta
specifying the claimed particulars of such breach and its desire to fully terminate this Agreement with the consequences as set forth in Section 16.2. In the event such material breach is not cured within the relevant time period specified
below after such notice, Novartis shall have the right thereafter to terminate this Agreement immediately with the consequences as set forth in Section 16.2 by giving written notice to Enanta to such effect. Enanta shall have [*****] days to
either cure such breach or, if cure cannot be reasonably effected within such [*****] day period, to deliver to Novartis a plan for curing such breach which is reasonably sufficient to effect a cure within a reasonable period not to exceed [*****]
days. Following delivery of such plan, Enanta shall use commercially reasonable efforts to carry out the plan and cure the breach. Any termination by Novartis under this Section and the effects of termination provided herein shall be without
prejudice to any damages or other legal or equitable remedies to which it may be entitled from Enanta. 

  

	 	(d)	Either Enanta or Novartis may terminate this Agreement without notice if an Insolvency Event occurs in relation to the other Party. In any event when a Party first
becomes aware of the likely occurrence of any Insolvency Event in regard to that Party, it shall promptly so notify the other Party in sufficient time to give the other Party sufficient notice to protect its interests under this Agreement.

  

	 	(e)	Novartis may terminate this Agreement in the event Enanta rejects this Agreement under Section 365 of the United States Bankruptcy Code, 11 U.S.C. §§ 101
et seq. (the “Code”). 

  

					
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	15.3	Termination by Novartis Without Cause. Novartis may terminate this Agreement without cause at any time after the Effective Date in its entirety or on a Licensed
Compound-by-Licensed Compound basis at any time on one hundred twenty (120) days’ prior written notice to Enanta. 

  

	15.4	Termination by Enanta For Failure of Novartis to Use Commercially Reasonable Efforts. 

 

	 	(a)	Subject to Section 15.4(b), Enanta shall have the right to terminate the rights licensed to Novartis under the Agreement with respect to a given Product if
Novartis is in breach of its obligations as set forth in Sections 7.2 or 9.1 with respect to such Product, provided however, that Novartis’ rights shall not terminate unless (i) Novartis is given [*****] days prior written notice by Enanta
of Enanta’s intent to terminate, stating the reasons and justification for such termination, and (ii) Novartis, or its Affiliate or sublicensee, has not taken good faith commercially reasonable steps during the [*****] day period following
such notice to diligently pursue the Development and/or Commercialization of the relevant Product. 

  

	 	(b)	If Novartis disputes in good faith the existence or materiality of an alleged breach specified in a notice provided by Enanta pursuant to Section 15.4(a), and
Novartis provides notice to Enanta of such dispute within the first [*****] days of the [*****] day notice period specified in Section 15.4(a), Enanta shall not have the right to terminate rights under this Agreement unless and until the
existence of such material breach or failure by Novartis has been determined in accordance with Section 20.5 and Novartis fails to cure such breach within [*****] days following such determination. It is understood and acknowledged that during
the pendency of any such dispute, all of the terms and conditions of this Agreement shall remain in effect and the Parties shall continue to perform all of their respective obligations hereunder. 

 

	15.5	Rights in Bankruptcy. 

  

	 	(a)	 The Parties agree that this Agreement constitutes an executory contract under Section 365 of the Code for the license of “intellectual
property” as defined under Section 101 of the Code and constitutes a license of “intellectual property” for purposes of any similar laws in any other country in the Territory. The Parties further agree that Novartis, as licensee
of such rights under this Agreement, will retain and may fully exercise all of its protections, rights and elections under the Code, including, but not limited to, Section 365(n) of the Code, and any similar laws in any other country in the
Territory. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against Enanta under the Code and any similar laws in any other country in the Territory, Novartis will be entitled to a complete duplicate
of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property to the extent included in the license grants hereunder and

  

					
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reasonably related to the practice of such license, and the same, if not already in its possession, will be promptly delivered to it: (i) upon any such commencement of a bankruptcy
proceeding upon its written request therefor, unless Enanta elects to continue to perform all of its obligations under this Agreement; or (ii) if not delivered under (i) above, following the rejection of this Agreement by or on behalf of
Enanta upon written request therefor by Novartis. 

  

	 	(b)	All rights, powers and remedies of Novartis provided for in this Section 15.5 are in addition to and not in substitution for any and all other rights, powers and
remedies now or hereafter existing at law or in equity (including, without limitation, under the Code and any similar laws in any other country in the Territory). In the event of an Insolvency Event in relation to Enanta, Novartis, in addition to
the rights, power and remedies expressly provided herein, shall be entitled to exercise all other such rights and powers and resort to all other such remedies as may now or hereafter exist at law or in equity (including, without limitation, under
the Code). 

  

	16.	EFFECT OF TERMINATION 

  

	16.1	Partial Termination by Novartis for Cause. Upon partial termination of this Agreement by Novartis pursuant to Section 15.2(b): 

 

	 	(a)	any licenses granted by Novartis to Enanta hereunder will terminate and revert to Novartis; 

 

	 	(b)	the licenses and other rights granted by Enanta to Novartis and its Affiliates under Article 3 will remain in effect in accordance with their respective terms;
provided, however, that (i) the amount of any Milestone Payments and royalties applicable to Net Sales of Product which become due after the effective date of partial termination shall be reduced by [*****]; and (ii) Novartis shall have
the right to offset any damages Novartis has suffered as a result of Enanta’s breach, in such amounts as are finally determined to be due to Novartis pursuant to Section 20.5 or otherwise agreed by Enanta in writing, against any such
Milestone Payments and/or royalties which become due after the effective date of partial termination; and 

  

	 	(c)	the Agreement will otherwise remain in full force and effect except that (i) Novartis will have the right to dissolve the JSC upon written notice to Enanta,
(ii) Novartis’ obligations pursuant to Section 4.2 will terminate, and (iii) Enanta’s rights to Co-Detail Products pursuant to Article 10 will terminate and Novartis will have the right to immediately terminate any
Co-Detailing Agreement by providing written notice to Enanta. 

  

	16.2	Full Termination by Novartis for Cause. Upon termination of this Agreement by Novartis pursuant to Section 15.2(c), (d) or (e):

  

	 	(a)	any licenses and other rights granted by either Party to the other Party hereunder will terminate and revert to the granting Party; 

  

					
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	 	(b)	Novartis will cooperate with Enanta promptly and as reasonably requested by Enanta to transition the responsibility for the filing, prosecution, and maintenance of the
Enanta IP back to Enanta. The provisions of Section 13.2 shall continue to apply with respect to Collaboration IP unless otherwise agreed in writing by the Parties; 

 

	 	(c)	Novartis hereby grants Enanta a right of first negotiation, exercisable by written notice to Novartis at any time within [*****] days after such termination, to obtain
a worldwide, exclusive, royalty-bearing license, with the right to sublicense, under Collaboration IP owned in whole or in part by Novartis or its Affiliates, and under any other Patent Rights and Know-How Controlled by Novartis or its Affiliates
that are not included in the Collaboration IP and that are reasonably necessary to continue to Develop or Commercialize Products then being Developed or Commercialized under this Agreement, to research, develop, make, have made, use, sell, have
sold, offer for sale and import Licensed Compound(s) and Product(s), on commercially reasonable terms to be negotiated in good faith by the Parties for up to an additional [*****] days following exercise of such right of first negotiation;

  

	 	(d)	any license granted to Enanta as described in the preceding subsection (c) will include, to the extent requested by Enanta, the right to use clinical and
regulatory data and information generated by Novartis for regulatory purposes relating to the Licensed Compounds and/or Products and will provide for Novartis to transfer and assign to Enanta all of its right, title and interest in and to all
regulatory submissions and Regulatory Approvals and all drug master files and drug dossiers with respect to the Products (other than those related to manufacturing facilities); and 

 

	 	(e)	except as set forth in this Section 16, the rights and obligations of the Parties hereunder shall terminate as of the date of such termination.

  

	16.3	Termination by Enanta for Cause or by Novartis Without Cause. Upon termination of this Agreement by Enanta pursuant to Section 15.2(a) or (d) or
Section 15.4 or by Novartis pursuant to Section 15.3: 

  

	 	(a)	any licenses and other rights granted by either Party to the other under this Agreement will terminate and revert to the granting Party; 

 

	 	(b)	Novartis will cooperate with Enanta promptly and as reasonably requested by Enanta to transition the responsibility for the filing, prosecution, and maintenance of the
Enanta IP back to Enanta. The provisions of Section 13.2 shall continue to apply with respect to Collaboration IP unless otherwise agreed in writing by the Parties; 

  

					
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	 	(c)	Novartis will transfer and assign to Enanta all of its right, title and interest in and to all regulatory submissions with respect to the Products that were filed by
Enanta prior to the Effective Date and transferred to Novartis hereunder; 

  

	 	(d)	 in the event that this Agreement is terminated on or before the 2nd anniversary of the end of the Research Term, then Novartis will grant Enanta and its Affiliates a worldwide,
exclusive, fully paid, perpetual license, with the right to sublicense, under all Collaboration IP owned in whole or in part by Novartis or its Affiliates, to research, develop, make, have made, use, sell, have sold, offer for sale and import
Licensed Compound(s) and Product(s); 

  

	 	(e)	 in the event that this Agreement is terminated after the 2nd anniversary of the end of the Research Term, then the Parties shall negotiate in good faith the terms under which
Enanta shall obtain a worldwide, exclusive, license, with the right to sublicense, under Collaboration IP owned in whole or in part by Novartis or its Affiliates, to develop, make, have made, use, sell, have sold, offer for sale and import Licensed
Compounds and Products; 

  

	 	(f)	in addition to the foregoing, upon request of Enanta following any such termination, the Parties shall negotiate in good faith the terms under which Enanta shall obtain
a worldwide, exclusive, royalty-bearing license, with the right to sublicense, under any other Patent Rights and Know-How Controlled by Novartis or its Affiliates that are not included in the Collaboration IP and that are reasonably necessary to
continue to Develop or Commercialize Products then being Developed or Commercialized under this Agreement, to develop, make, have made, use, sell, have sold, offer for sale and import any such Product then being Developed or Commercialized under
this Agreement; 

  

	 	(g)	 in the event that the Parties cannot agree upon the terms for any license to be negotiated as provided above within [*****] days after such
termination, then, if requested by Enanta during such [*****] day period, the Parties shall refer the matter to arbitration before a mutually acceptable single independent arbitrator, who shall be experienced in the pharmaceutical business, provided
that if the Parties cannot agree upon such single arbitrator within [*****] days, such arbitrator will be promptly chosen by the Parties in accordance with the then-prevailing rules of arbitration of the International Chamber of Commerce. For such
arbitration, each Party shall submit final proposed terms to the arbitrator within [*****] days of his/her appointment, together with a brief or other written memorandum supporting the merits of their final proposal, provided that each Party will
submit its final proposed terms to the other Party at least [*****] days prior to submission to the independent arbitrator. The arbitrator shall promptly convene a hearing, at which time each Party shall have an agreed upon time to argue and present
witnesses in support of its final proposal. The independent arbitrator will select between the two sets of terms (i.e., the independent arbitrator will select one of the sets of terms submitted by the Parties, and will not propose a third set of
terms, and shall have no discretion or authority with respect to 

  

					
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modifying the proposed terms of either of the Parties), and shall render his/her opinion in writing within [*****] days after the hearing described above. The decision of the arbitrator shall be
final and binding on the Parties. The Parties shall equally bear all expenses and costs of the arbitration, including the costs associated with the arbitrators’ services, but not the costs incurred by either Party in connection with the
preparation for and the presentation of its case. 

  

	 	(h)	any license granted to Enanta as described in the preceding subsection (e) or (f) will include, to the extent requested by Enanta, the right to use clinical
and regulatory data and information generated by Novartis for regulatory purposes relating to the Licensed Compounds and/or Products and will provide for Novartis to transfer and assign to Enanta all of its right, title and interest in and to all
regulatory submissions and Regulatory Approvals and all drug master files and drug dossiers with respect to the Products (other than those related to manufacturing facilities) and for Novartis to reasonably cooperate with Enanta, at Enanta’s
request and expense, with respect to the transfer of relevant Development and Commercialization activities to Enanta, and to provide Enanta with reasonable access to relevant manufacturing and formulation Know-How; and 

 

	 	(i)	except as set forth in this Section 16, the rights and obligations of the Parties hereunder shall terminate as of the date of such termination.

  

	16.4	Survival. Expiration or termination of this Agreement shall not relieve the Parties of any obligation accruing prior to such expiration or termination. Without
limiting the foregoing, the provisions of Articles 1, 12, 16, 18 and 20, and Sections 3.4, 11.10, 13.1, 15.5, 17.4, 19.2, and any other obligations and rights which are expressly intended to survive, shall survive expiration or termination of this
Agreement. The provisions of Section 14 (Confidentiality) shall survive the termination or expiration of this Agreement for a period of [*****] years. 

 

	16.5	Termination Not Sole Remedy. Termination is not the sole remedy under this Agreement and, whether or not termination is effected and notwithstanding anything
contained in this Agreement to the contrary, all other remedies will remain available except as agreed to otherwise herein. 

  

	17.	REPRESENTATIONS, WARRANTIES AND COVENANTS 

  

	17.1	Representations, Warranties and Covenants by Each Party. Each Party represents and warrants to the other as of the Effective Date that: 

 

	 	(a)	it is a corporation duly organized, validly existing, and in good standing under the laws of its jurisdiction of formation; 

 

	 	(b)	it has full corporate power and authority to execute, deliver, and perform this Agreement, and has taken all corporate action required by law and its organizational
documents to authorize the execution and delivery of this Agreement and the consummation of the transactions contemplated by this Agreement; 

  

					
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	 	(c)	this Agreement constitutes a valid and binding agreement enforceable against it in accordance with its terms; 

 

	 	(d)	other than compliance with the HSR Act, all consents, approvals and authorizations from all governmental authorities or other Third Parties required to be obtained by
such Party in connection with this Agreement have been obtained; 

  

	 	(e)	the execution and delivery of this Agreement and all other instruments and documents required to be executed pursuant to this Agreement do not and shall not
(i) conflict with or result in a breach of any provision of its organizational documents, (ii) result in a breach of any agreement to which it is a party; or (iii) violate any law; and 

 

	 	(f)	all of its employees, officers, and consultants who have been involved with the Enanta IP or who will be involved in the Research Program have executed agreements or
have existing obligations under applicable laws requiring assignment to such Party of all inventions made during the course of and as the result of their association with such Party free from Encumbrances and obligating the individual to maintain as
confidential such Party’s Confidential Information as well as confidential information of other parties (including the other Party and its Affiliates) which such individual may receive, to the extent required to support such Party’s
obligations under this Agreement; 

  

	 	(g)	with respect to Novartis, it shall self-insure and, with respect to Enanta, it shall maintain insurance with respect to its activities and obligations under this
Agreement in such amounts as are commercially reasonable in the industry for companies conducting similar business and shall require any of its Affiliates undertaking activities under this Agreement to do the same; 

 

	 	(h)	it will perform all activities under this Agreement in compliance with all applicable laws and regulations, including but not limited to those relating to the conduct
of human clinical studies, animal testing, biotechnological research and the handling and containment of biohazardous materials, and laws and regulations relating to health, safety and the environment, fair labor practices and unlawful
discrimination; 

  

	 	(i)	 (i) neither such Party nor, to the actual knowledge of such Party, any employee, agent or subcontractor of such Party involved or to be involved in the
Development of the Licensed Compound(s) and/or the Product(s) has been debarred under Subsection (a) or (b) of Section 306 of the Federal Food, Drug and Cosmetic Act (21 U.S.C. 335a); (ii) no Person who is known by such Party to
have been debarred under Subsection (a) or (b) of Section 306 of said Act will be employed by such Party in the performance of any activities hereunder; and (iii) to the actual knowledge of such Party, no Person on any of the FDA
clinical 

  

					
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investigator enforcement lists (including, but not limited to, the (1) Disqualified/Totally Restricted List, (2) Restricted List and (3) Adequate Assurances List) will participate
in the performance of any activities hereunder. 

  

	17.2	Representations and Warranties by Enanta. Enanta represents and warrants to Novartis as of the Effective Date that: 

 

	 	(a)	Exhibit A sets forth a complete and accurate list of all Enanta Patents in existence as of the Effective Date, indicating the owner, Enanta, and/or co-owner(s)
thereof if such Enanta IP is not solely owned by Enanta; 

  

	 	(b)	Exhibit A includes a complete list of all the patents and patent applications that Enanta has filed on novel NS5A compound structures; 

 

	 	(c)	Enanta is the sole and exclusive owner of all of the Enanta Patents free from Encumbrances, and is listed in the records of the appropriate governmental agencies as the
sole and exclusive owner of record for each registration, grant and application included in the Enanta Patents; 

  

	 	(d)	Enanta has the right to grant to Novartis and its Affiliates the licenses under the Enanta IP that it purports to grant hereunder; 

 

	 	(e)	Enanta has the right to use and disclose and to enable Novartis and its Affiliates to use and disclose (in each case under appropriate conditions of confidentiality)
the Enanta Know-How to be licensed to Novartis as provided under this Agreement; 

  

	 	(f)	to the Knowledge of Enanta, the issued patents in the Enanta Patents are valid and enforceable without any claims, challenges, oppositions, interference or other
similar proceedings, pending or threatened, and Enanta has filed and prosecuted patent applications within the Enanta Patents in good faith and complied with all duties of disclosure with respect thereto; 

 

	 	(g)	to the Knowledge of Enanta, Enanta has not committed any act, or omitted to commit any act, that may cause the Enanta Patents to expire prematurely or be declared
invalid or unenforceable; 

  

	 	(h)	to the Knowledge of Enanta, all application, registration, maintenance and renewal fees in respect of the Enanta Patents due as of the Effective Date have been paid and
all necessary documents and certificates have been filed with the relevant agencies for the purpose of maintaining the Enanta Patents; 

  

	 	(i)	Enanta has not granted to any Third Party any rights to the Licensed Compound(s) that would otherwise interfere or be inconsistent with rights granted to Novartis
hereunder; 

  

	 	(j)	[*****]; 

  

	 	(k)	[*****]; 

  

	 	(l)	[*****]; and 

  

	 	(m)	[*****]. 

  

	17.3	Covenants of Enanta. Enanta covenants and agrees that: 

  

	 	(a)	it will not grant any interest in the Enanta IP which is inconsistent with the terms and conditions of this Agreement, nor shall Enanta assign its right, title or
interest in or to the Enanta IP to any Third Party except as permitted in Section 20.1; and 

  

					
		  	 Confidential materials omitted and filed separately with the Securities and Exchange

Commission. Asterisks denote such omission.
	  	
 46

	 	(b)	if, at any time after execution of this Agreement, it becomes aware that it or any employee, agent or subcontractor of Enanta who participated, or is participating, in
the performance of any activities hereunder is on, or is being added to the FDA Debarment List or any of the three (3) FDA Clinical Investigator Restriction Lists referenced in Section 17.1(i), it will provide written notice of this to
Novartis within two (2) business days of its becoming aware of this fact; 

  

	 	(c)	subject to Section 14.3, it will use all reasonable precautions to preserve the confidentiality of the Enanta Know-How to the extent that such Enanta Know-How is
subject to an exclusive license to Novartis and its Affiliates. 

  

	17.4	No Other Warranties. EXCEPT AS EXPRESSLY STATED IN THIS SECTION 17, (A) NO REPRESENTATION, CONDITION OR WARRANTY WHATSOEVER IS MADE OR GIVEN BY OR ON BEHALF
OF NOVARTIS OR ENANTA; AND (B) ALL OTHER CONDITIONS AND WARRANTIES WHETHER ARISING BY OPERATION OF LAW OR OTHERWISE ARE HEREBY EXPRESSLY EXCLUDED, INCLUDING ANY CONDITIONS AND WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE OR
NON-INFRINGEMENT. 

  

	18.	INDEMNIFICATION; LIABILITY 

  

	18.1	Indemnification by Enanta. Enanta shall indemnify and hold Novartis, its Affiliates, and their respective officers, directors and employees (“Novartis
Indemnitees”) harmless from and against any Claims against them to the extent arising or resulting from: 

  

	 	(a)	Enanta’s, or any of its Affiliates’, sublicensees’ or contractors’ actions in connection with the Research Program; 

 

	 	(b)	the negligence or willful misconduct of Enanta or any of its Affiliates; or 

 

	 	(c)	the breach of any of the obligations, covenants, warranties or representations made by Enanta to Novartis and its Affiliates under this Agreement;

 provided, however, that Enanta shall not be obliged to so indemnify, defend and hold harmless the Novartis
Indemnitees for any Claims to the extent Novartis has an obligation to indemnify Enanta Indemnitees pursuant to Section 18.2 or to the extent that such Claims arise from the breach, negligence or willful misconduct of Novartis or the Novartis
Indemnitee. 
  

	18.2	Indemnification by Novartis. Novartis shall indemnify and hold Enanta, its Affiliates, and their respective officers, directors and employees (“Enanta
Indemnitees”) harmless from and against any Claims against them to the extent arising or resulting from: 

  

	 	(a)	Novartis’, or any of its Affiliates’, sublicensees’ or contractors’ actions in connection with the Development, manufacture or Commercialization of
the Licensed Compound(s) or Product(s) or performance of the Research Program; 

  

					
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	 	(b)	the negligence or willful misconduct of Novartis or any of its Affiliates; or 

 

	 	(c)	the breach of any of the obligations, covenants, warranties or representations made by Novartis to Enanta under this Agreement; 

provided, however, that Novartis and its Affiliates shall not be obliged to so indemnify, defend and hold harmless the Enanta Indemnitees
for any Claims to the extent Enanta has an obligation to indemnify Novartis Indemnitees pursuant to Section 18.1 or to the extent that such Claims arise from the breach, negligence or willful misconduct of Enanta or the Enanta Indemnitee.

  

	18.3	Indemnification Procedure. 

  

	 	(a)	For the avoidance of doubt, all indemnification claims in respect of a Novartis Indemnitee or Enanta Indemnitee shall be made solely by Novartis or Enanta,
respectively. 

  

	 	(b)	A Party seeking indemnification hereunder (“Indemnified Party”) shall notify the other Party (“Indemnifying Party”) in writing
reasonably promptly after the assertion against the Indemnified Party of any Claim or fact in respect of which the Indemnified Party intends to base a Claim for indemnification hereunder (“Indemnification Claim Notice”), but
the failure or delay to so notify the Indemnifying Party shall not relieve the Indemnifying Party of any obligation or liability that it may have to the Indemnified Party, except to the extent that the Indemnifying Party demonstrates that its
ability to defend or resolve such Claim is adversely affected thereby. The Indemnification Claim Notice shall contain a description of the Claim and the nature and amount of the Claim (to the extent that the nature and amount of such Claim is known
at such time). Upon the request of the Indemnifying Party, the Indemnified Party shall furnish promptly to the Indemnifying Party copies of all correspondence, communications and official documents (including court documents) received or sent in
respect of such Claim. 

  

	 	(c)	 Subject to the provisions of subsections (d) and (e) below, the Indemnifying Party shall have the right, upon written notice given to the
Indemnified Party within thirty (30) days after receipt of the Indemnification Claim Notice, to assume the defense and handling of such Claim, at the Indemnifying Party’s sole expense, in which case the provisions of subsection
(d) below shall govern. The assumption of the defense of a Claim by the Indemnifying Party shall not be construed as acknowledgement that the Indemnifying Party is liable to indemnify any indemnitee in respect of the Claim, nor shall it
constitute a waiver by the Indemnifying Party of any defenses it may assert against any Indemnified Party’s claim for indemnification. In the event that it is ultimately decided that the Indemnifying Party is not obligated to indemnify or hold
an Indemnitee harmless 

  

					
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from and against the Claim, the Indemnified Party shall reimburse the Indemnifying Party for any and all costs and expenses (including attorneys’ fees and costs of suit) and any losses
incurred by the Indemnifying Party in its defense of the Claim. If the Indemnifying Party does not give written notice to the Indemnified Party, within thirty (30) days after receipt of the Indemnification Claim Notice, of the Indemnifying
Party’s election to assume the defense and handling of such Claim, the provisions of sub-Section (e) below shall govern. 

  

	 	(d)	Upon assumption of the defense of a Claim by the Indemnifying Party: (i) the Indemnifying Party shall have the right to and shall assume sole control and
responsibility for dealing with the Claim; (ii) the Indemnifying Party may, at its own cost, appoint as counsel in connection with conducting the defense and handling of such Claim any law firm or counsel reasonably selected by the Indemnifying
Party; (iii) the Indemnifying Party shall keep the Indemnified Party informed of the status of such Claim; and (iv) the Indemnifying Party shall have the right to settle the Claim on any terms the Indemnifying Party chooses; provided,
however, that it shall not, without the prior written consent of the Indemnified Party, agree to a settlement of any Claim which could lead to liability or create any financial or other obligation on the part of the Indemnified Party for which the
Indemnified Party is not entitled to indemnification hereunder or which admits any wrongdoing or responsibility for the claim on behalf of the Indemnified Party. The Indemnified Party shall cooperate with the Indemnifying Party and shall be entitled
to participate in, but not control, the defense of such Claim with its own counsel and at its own expense. In particular, the Indemnified Party shall furnish such records, information and testimony, provide witnesses and attend such conferences,
discovery proceedings, hearings, trials and appeals as may be reasonably requested in connection therewith. Such cooperation shall include access during normal business hours by the Indemnifying Party to, and reasonable retention by the Indemnified
Party of, records and information that are reasonably relevant to such Claim, and making the Indemnified Party, the Indemnitees and its and their employees and agents available on a mutually convenient basis to provide additional information and
explanation of any records or information provided. 

  

	 	(e)	If the Indemnifying Party does not give written notice to the Indemnified Party as set forth in subsection (c) or fails to conduct the defense and handling of any
Claim in good faith after having assumed such, the Indemnified Party may, at the Indemnifying Party’s expense, select counsel reasonably acceptable to the Indemnifying Party in connection with conducting the defense and handling of such Claim
and defend or handle such Claim in such manner as it may deem appropriate. In such event, the Indemnified Party shall keep the Indemnifying Party timely apprised of the status of such Claim and shall not settle such Claim without the prior written
consent of the Indemnifying Party, which consent shall not be unreasonably withheld. If the Indemnified Party defends or handles such Claim, the Indemnifying Party shall cooperate with the Indemnified Party, at the Indemnified Party’s request
but at no expense to the Indemnified Party, and shall be entitled to participate in the defense and handling of such Claim with its own counsel and at its own expense. 

  

					
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	18.4	Mitigation of Loss. Each Indemnified Party will take and will procure that its Affiliates take all such reasonable steps and action as are necessary or as the
Indemnifying Party may reasonably require in order to mitigate any Claims (or potential losses or damages) under this Section 18. Nothing in this Agreement shall or shall be deemed to relieve any Party of any common law or other duty to
mitigate any losses incurred by it. 

  

	18.5	Special, Indirect and Other Losses. NEITHER PARTY NOR ANY OF ITS AFFILIATES SHALL BE LIABLE IN CONTRACT, TORT, NEGLIGENCE BREACH OF STATUTORY DUTY OR OTHERWISE
FOR ANY SPECIAL, INDIRECT, INCIDENTAL, PUNITIVE OR CONSEQUENTIAL DAMAGES OR FOR ANY LOSS OF PROFITS SUFFERED BY THE OTHER PARTY, EXCEPT TO THE EXTENT ANY SUCH DAMAGES ARE REQUIRED TO BE PAID TO A THIRD PARTY AS PART OF A CLAIM FOR WHICH A PARTY
PROVIDES INDEMNIFICATION UNDER THIS SECTION 18. 

  

	18.6	No Exclusion. Neither Party excludes any liability for death or personal injury caused by its negligence or that of its employees, agents or sub-contractors.

  

	19.	PUBLICATIONS AND PUBLICITY 

  

	19.1	Publications. 

  

	 	(a)	Except to the extent made in accordance with the provisions of Section 14 or Section 19.2, any proposed public disclosure (whether written, electronic, oral
or otherwise) by Enanta relating to the Licensed Compound(s) or Product(s) shall require the prior written consent of Novartis. 

  

	 	(b)	For the avoidance of doubt, Novartis or any of its Affiliates may, without any required consents from Enanta, but, to the extent practicable, with at least [*****]
days’ prior written notice to Enanta, publish or have published information about clinical trials related to the Licensed Compound(s) or Product(s), including the results of such clinical trials. This paragraph shall not affect the rights or
obligations of the Parties pursuant to Section 14. 

  

	19.2	Publicity. 

  

	 	(a)	Neither Party shall use the name, symbol, trademark, trade name or logo of the other Party or its Affiliates in any press release, publication or other form of public
disclosure without the prior written consent of the other Party in each instance (such consent not to be unreasonably withheld or delayed), except for those disclosures made in accordance with Section 14 or for which consent has already been
obtained. 

  

	 	(b)	Except as provided in Section 14, each Party agrees not to issue any press release or other public statement, whether oral or written, disclosing the existence of
this Agreement, the terms hereof or any information relating to this Agreement without the prior written consent of the other Party, which consent shall not be unreasonably withheld or delayed; provided, however, that Novartis may issue press
releases and other public statements as it deems reasonably appropriate in connection with the Development and Commercialization of Products under this Agreement without such consent but, to the extent practicable, with at least [*****] days’
prior written notice to Enanta. 

  

					
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	19.3	The Parties acknowledge and agree that a good faith breach by Novartis of any requirement to give prior notice pursuant to this Section 19 shall not be
grounds for any termination of this Agreement by Enanta. 

  

	20.	GENERAL PROVISIONS 

  

	20.1	Assignment. This Agreement may not be assigned or otherwise transferred by either Party without the prior written consent of the other Party; provided, however,
that either Party may assign this Agreement, without the consent of the other Party to any of its Affiliates or to a successor to all or substantially all of its business or assets to which this Agreement relates. Any purported assignment in
contravention of this Section 20.1 shall, at the option of the non-assigning Party, be null and void and of no effect. In the event that this Agreement is assigned by a Party in connection with the sale or transfer of all or substantially all
of the business and assets of such Party to which the subject matter of this Agreement pertains, notwithstanding any provisions of this Agreement to the contrary, such assignment shall not provide the non-assigning Party with rights or access to
intellectual property or technology of the acquirer of the assigning Party. No assignment shall release either Party from responsibility for the performance of any accrued obligation of such Party hereunder. This Agreement shall be binding upon and
enforceable against the successor to or any permitted assignees from either of the Parties hereto. 

  

	20.2	Extension to Affiliates. Novartis shall have the right to extend the rights, immunities and obligations granted in this Agreement to one or more of its
Affiliates. All applicable terms and provisions of this Agreement shall apply to any such Affiliate to which this Agreement has been extended to the same extent as such terms and provisions apply to Novartis. Novartis shall remain primarily liable
for any acts or omissions of its Affiliates. 

  

	20.3	Severability. Should one or more of the provisions of this Agreement become void or unenforceable as a matter of law, then this Agreement shall be construed as
if such provision were not contained herein and the remainder of this Agreement shall be in full force and effect, and the Parties will use their commercially reasonable efforts to substitute for the invalid or unenforceable provision a valid and
enforceable provision which conforms as nearly as possible with the original intent of the Parties. 

  

					
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	20.4	Governing Law and Jurisdiction. This Agreement shall be governed by and construed under the laws of the Commonwealth of Massachusetts, without reference to
conflicts of laws principles. The Parties hereby irrevocably submit to the exclusive jurisdiction of and venue in the state and federal courts located in Boston, Massachusetts, without restricting any right of appeal. 

 

	20.5	Dispute Resolution. 

  

	 	(a)	Except as otherwise set forth in this Agreement, in the event of an unresolved matter, dispute or issue under this Agreement (“Dispute”), the Parties
will refer the Dispute to the Alliance Managers for discussion and resolution. If the Alliance Managers are unable to resolve such Dispute within thirty (30) days of the Dispute being referred to them by either Party in writing, either Party
may require that the Parties forward the matter to the Senior Officers (or designees with similar authority to resolve such dispute), who shall attempt in good faith to resolve such Dispute. If the Senior Officers cannot resolve such Dispute within
thirty (30) days of the matter being referred to them in writing, then the Dispute will be resolved as provided in Section 20.5(b), (c) or (d) below, as applicable. 

 

	 	(b)	For any Dispute not settled in accordance with Section 20.5(a), a Party wishing to commence arbitration shall first serve notice on the other Party that a Dispute
has arisen and demand that mediation commence. The mediation shall last no longer than sixty (60) days and shall be conducted pursuant to the ICC ADR Rules of the International Chamber of Commerce (“ICC”) then in effect. Each Party
shall pay its own expenses incurred in connection with such mediation, and the fees and expenses of the mediator shall be divided evenly between the Parties. Notwithstanding anything else contained herein, any Party to such mediation shall have the
right to commence arbitration in accordance with Section 20.5(c) below at any time after the expiration of sixty (60) days after service of such demand for mediation under this subsection. 

 

	 	(c)	Any unresolved Disputes between the Parties relating to, arising out of or in any way connected with this Agreement or any term or condition hereof, or the performance
by either Party of its obligations hereunder, whether before or after termination of this Agreement, shall be resolved by final and binding arbitration. Whenever a Party shall decide to institute arbitration proceedings, it shall give written notice
to that effect to the other Party. Arbitration shall be held in Boston, Massachusetts, according to the Rules of Arbitration of the ICC in effect at the time of the arbitration, except as they may be modified herein or by mutual agreement of the
Parties. No arbitrator (nor any panel of arbitrators) shall have the power to award punitive damages under this Agreement and such award is expressly prohibited. Decisions of the arbitrator(s) shall be final and binding on the Parties. Judgment on
the award so rendered may be entered in any court of competent jurisdiction. The costs of the arbitration shall be borne as determined by the arbitrator(s). 

 

	 	(d)	Notwithstanding anything to the contrary, either Party may at any time seek to obtain preliminary injunctive relief or other applicable provisional relief from a court
of competent jurisdiction with respect to an issue arising under this Agreement if the rights of such Party would be prejudiced absent such relief. A request by a Party to a court of competent jurisdiction for interim measures necessary to preserve
the Party’s rights, including attachments or injunctions, shall not be deemed incompatible with, or a waiver of, the agreement to mediate or arbitrate contained in this Section 20.5. Notwithstanding anything to the contrary in this
Section 20.5, any disputes regarding the scope, validity, enforceability or inventorship of any patents or patent applications shall be submitted for final resolution by a court of competent jurisdiction. 

  

					
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	20.6	Force Majeure. Neither Party shall be responsible to the other for any failure or delay in performing any of its obligations under this Agreement or for other
nonperformance hereunder if such delay or nonperformance is caused by strike, stoppage of labor, lockout or other labor trouble, fire, flood, accident, war, act of terrorism, act of God or of the government of any country or of any local government,
or by cause unavoidable or beyond the control of any Party hereto. In such event, the Party affected will use commercially reasonable efforts to resume performance of its obligations. 

 

	20.7	Waivers and Amendments. The failure of any Party to assert a right hereunder or to insist upon compliance with any term or condition of this Agreement shall not
constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party. No waiver shall be effective unless it has been given in writing and signed by the Party giving such waiver. No
provision of this Agreement may be amended or modified other than by a written document signed by authorized representatives of each Party. 

  

	20.8	Relationship of the Parties. Nothing contained in this Agreement shall be deemed to constitute a partnership, joint venture, or legal entity of any type between
Enanta and Novartis, or to constitute one as the agent of the other. Moreover, each Party agrees not to construe this Agreement, or any of the transactions contemplated hereby, as a partnership for any tax purposes. Each Party shall act solely as an
independent contractor, and nothing in this Agreement shall be construed to give any Party the power or authority to act for, bind, or commit the other. 

  

	20.9	Notices. All notices, consents, waivers, and other communications under this Agreement must be in writing and will be deemed to have been duly given when:
(a) delivered by hand (with written confirmation of receipt); (b) sent by fax (with written confirmation of receipt), provided that a copy is immediately sent by an internationally recognized overnight delivery service (receipt requested);
or (c) when received by the addressee, if sent by an internationally recognized overnight delivery service (receipt requested), in each case to the appropriate addresses and fax numbers set forth below (or to such other addresses and fax
numbers as a Party may designate by notice): 

 If to Enanta: 

Enanta Pharmaceuticals, Inc. 
 500 Arsenal Street 
 Watertown, Massachusetts 02472 

Attention: Chief Executive Officer 
 Facsimile No.: 617-607-0530 

  

					
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 If to Novartis: 

Novartis Institutes for BioMedical Research, Inc. 
 250 Massachusetts Avenue 
 Cambridge, Massachusetts 02139 

Attention: General Counsel 
 Facsimile No.: (617) 871-3354 
  

	20.10	Further Assurances. Novartis and Enanta hereby covenant and agree without the necessity of any further consideration, to execute, acknowledge and deliver any and
all such other documents and take any such other action as may be reasonably necessary to carry out the intent and purposes of this Agreement. 

  

	20.11	Compliance with Law. Each Party shall perform its obligations under this Agreement in accordance with all applicable laws. No Party shall, or shall be required
to, undertake any activity under or in connection with this Agreement which violates, or which it believes, in good faith, may violate, any applicable law. 

 

	20.12	Corporate Citizenship. Novartis gives preference to parties who share Novartis’ societal and environmental values as set forth in the “Novartis Third
Party Code of Conduct” which is attached as Exhibit D. 

  

	20.13	No Third Party Beneficiary Rights. The provisions of this Agreement are for the sole benefit of the Parties and their successors and permitted assigns, and they
shall not be construed as conferring any rights to any Third Party (including any third party beneficiary rights). 

  

	20.14	English Language. This Agreement is written and executed in the English language. Any translation into any other language shall not be an official version of
this Agreement and in the event of any conflict in interpretation between the English version and such translation, the English version shall prevail. 

  

	20.15	Expenses. Except as otherwise expressly provided in this Agreement, each Party shall pay the fees and expenses of its respective lawyers and other experts and
all other expenses and costs incurred by such Party incidental to the negotiation, preparation, execution and delivery of this Agreement. 

  

	20.16	Entire Agreement. This Agreement, together with its Exhibits, sets forth the entire agreement and understanding of the Parties as to the subject matter hereof
and supersedes all proposals, oral or written, and all other prior communications between the Parties with respect to such subject matter. In the event of any conflict between a substantive provision of this Agreement and any Exhibit hereto, the
substantive provisions of this Agreement shall prevail. 

  

					
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	20.17	Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute
one and the same instrument. 

  

	20.18	Cumulative Remedies. No remedy referred to in this Agreement is intended to be exclusive, but each shall be cumulative and in addition to any other remedy
referred to in this Agreement or otherwise available under law. 

 IN WITNESS WHEREOF, the Parties intending to be
bound have caused this Agreement to be executed by their duly authorized representatives. 
  

									
	NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH, INC.	 		 	ENANTA PHARMACEUTICALS, INC.
					
	By:	 	 /s/ Christian Klee
	 		 	By:	 	 /s/ Jay R. Luly

					
	Name:	 	 Christian Klee
	 		 	Name:	 	 Jay R. Luly

					
	Title:	 	 VP and CFO
	 		 	Title:	 	 President and CEO

  

					
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 55

 Exhibit 10.2 
 Enanta has requested that portions of this document be accorded confidential treatment 
 pursuant to Rule 24b-2 promulgated under the Securities Exchange Act of 1934, as 
 amended. 
 EXHIBIT A 

ENANTA PATENTS 
  

													
	 Country Name
	  	 Sub
	  	 Status
	  	 Appl’n #
	  	 Filing Date
	  	Patent #	  	Issue Date
	
	 4014.1182 (ENP-182) “Linked Dibenzimidazole Antivirals”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 Patent Cooperation Treaty
	  		  	 Natl Proc
	  	 US10/023645
	  	 09-Feb-2010
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/151,079
	  	 09-Feb-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1183 (ENP-183) “Novel Dibenzimidazole Derivatives”

							
	 United States of America
	  		  	 PRO
	  	 61/153,224
	  	 17-Feb-2009
	  		  	
	 United States of America
	  	 1
	  	 PRO
	  	 61/156,239
	  	 27-Feb-2009
	  		  	
	 United States of America
	  	 2
	  	 ORD
	  	 12/702,692
	  	 09-Feb-2012
	  		  	
	
	 4014.1184 (ENP-184) “Linked Dibenzimidazole Derivatives”

							
	 United States of America
	  		  	 Expired
	  	 61/153,231
	  	 17-Feb-2009
	  		  	
	 United States of America
	  	 1
	  	 Expired
	  	 61/156,110
	  	 27-Feb-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1185 (ENP-185) “Linked Dilmidazole Antivirals”

							
	 Patent Cooperation Treaty
	  		  	 Natl Proc
	  	 US10/024447
	  	 17-Feb-2010
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/153,234
	  	 17-Feb-2009
	  		  	
	 United States of America
	  	 1
	  	 Expired
	  	 61/156,160
	  	 27-Feb-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1186 (ENP-186) “Novel Dilmidazole Antivirals”

							
	 United States of America
	  		  	 PRO
	  	 61/153,240
	  	 17-Feb-2009
	  		  	
	 United States of America
	  	 1
	  	 PRO
	  	 61/156,284
	  	 27-Feb-2009
	  		  	
	 United States of America
	  	 2
	  	 ORD
	  	 12/707,200
	  	 17-Feb-2010
	  		  	
	
	 4014.1187 (ENP-187) “Novel Benzimidazole Derivatives”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

													
	 Country Name
	  	 Sub
	  	 Status
	  	 Appl’n #
	  	 Filing Date
	  	Patent #	  	Issue Date
	 [*****]
	  		  	 [*****]
	  		  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  		  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  		  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 Patent Cooperation Treaty
	  		  	 Natl Proc
	  	 US10/025741
	  	 01-March-2010
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/156,131
	  	 27-Feb-2009
	  		  	
	 United States of America
	  	 1
	  	 Allowed
	  	 12/714,583
	  	 01-March-2010
	  	8101643	  	24-Jan-2012
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  	 3
	  	 Unfiled
	  		  		  		  	
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1188 (ENP-188) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 Expired
	  	 61/158,071
	  	 06-Mar-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1189 (ENP-189) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 Expired
	  	 61/156,268
	  	 27-Feb-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1190 (ENP-190) “Hepatitis C Virus Inhibitors”

							
	 Patent Cooperation Treaty
	  		  	 Natl Proc
	  	 US10/038699
	  	 15-Jun-2010
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/187,374
	  	 16-Jun-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	

  
 2 

													
	 Country Name
	  	 Sub
	  	 Status
	  	 Appl’n #
	  	 Filing Date
	  	Patent #	  	Issue Date
			
	 4014.1191 (ENP-191) “Hepatitis C Virus Inhibitors”
	  		  	
							
	 United States of America
	  		  	 Expired
	  	 61/222,586
	  	 02-Jul-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1192 (ENP-192) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/241,489
	  	 10-Sept-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1198 (ENP-198) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 Expired
	  	 61,241,578
	  	 11-Sep-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1199 (ENP-199) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 Expired
	  	 61/241,595
	  	 11-Sep-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1200 (ENP-200) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 PRO
	  	 61/241,617
	  	 11-Sep-2009
	  		  	
	 United States of America
	  	 1
	  	 ORD
	  	 12/879,028
	  	 10-Sep-2010
	  		  	
	
	 4014.1201 (ENP-201) “Hepatitis C Virus Inhibitors”

							
	 United States of America
	  		  	 Expired
	  	 61/241,577
	  	 11-Sep-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1202 (ENP-202) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/241,598
	  	 11-Sep-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1204 (ENP-204) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/286,178
	  	 14-Dec-2009
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1205 (ENP-205) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	

  
 3 

													
	 Country Name
	  	 Sub
	  	 Status
	  	 Appl’n #
	  	 Filing Date
	  	Patent #	  	Issue Date
	 United States of America
	  		  	 Expired
	  	 61/297,918
	  	 25-Jan-2010
	  		  	
	 United States of America
	  	 1
	  	 Expired
	  	 61/314,304
	  	 16-Mar-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1209 (ENP-209) “Combination Pharmaceutical Agents as Inhibitors of HCV
Replication”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/310,579
	  	 04-Mar-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1210 (ENP-210) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/322,438
	  	 09-Apr-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1211 (ENP-211) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/372,999
	  	 12-Aug-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	
	 4014.1216 (ENP-216) “Hepatitis C Virus Inhibitors”

							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 United States of America
	  		  	 Expired
	  	 61/351,327
	  	 04-Jun-2010
	  		  	
	 United States of America
	  	 1
	  	 Expired
	  	 61/415,447
	  	 19-Nov-2010
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
							
	 [*****]
	  		  		  		  		  		  	
							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
							
	 [*****]
	  		  		  		  		  		  	
							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	
							
	 [*****]
	  		  		  		  		  		  	
							
	 [*****]
	  		  	 [*****]
	  	 [*****]
	  	 [*****]
	  		  	

  
 4 

 Exhibit 10.2 
 Enanta has requested that portions of this document be accorded confidential treatment 
 pursuant to Rule 24b-2 promulgated under the Securities Exchange Act of 1934, as 
 amended. 
 EXHIBIT B 

RESEARCH PLAN 
 [*****]

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

 EXHIBIT C 
 SAMPLE INVOICE 
  

			
	Company Name	  	INVOICE
		
	Street Address	  	DATE: Month Day, Year
	City, State ZIP Code	  	INVOICE #: XX
	Phone 1xxxxxx	  	NOVARTIS PO#: XXXXXXXX
	Fax 1xxxxx	  	

 Bill To: 

Novartis Institutes for Biomedical Research 

Attn: Novartis Contact Name 
 P.O. Box 5990

 Portland, OR 97228-5990 

Upfront/Milestone/Royalty or any other payment debit in reference to Research Collaboration and License Agreement between Enanta Pharmaceuticals, Inc.
and Novartis Institutes for BioMedical Research, Inc. effective as of (date). 
  

							
	 PO Line
Number
	  	 DESCRIPTION
	  	AMOUNT	 
			
	1	  	Upfront payment with reference made to the relevant section of the contract	  	 	$XX.XX	  
		  		  	  
	  
	 
	 TOTAL
	  	 	$XX.XX	  
		  		  	  
	  
	 

  

			
	Remit to:
	Bank Wire Information:
	Bank Name:	 	XX
	Account No.:	 	XX
	ABA#:	 	XX (only applicable in the US)
	IBAN:	 	XX (only applicable in Europe)
	SWIFT CODE:	 	XX (applicable US and Europe)

 Note for e-mail submissions of invoices: 
 The address is: [*****] 
 Attached invoice files must contain a Novartis issued
purchase order number (PO) on them and cannot be zipped. Invoices without a PO number on them or zipped attachments will not be accepted for processing. 
 Note to Enanta: When payments shift to post-PoC, Novartis to provide Enanta with new contact information for the invoices. 

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

 EXHIBIT D 
 NOVARTIS THIRD PARTY CODE OF CONDUCT 
 [to be inserted] 

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

			
		  	Novartis Third Party Code of Conduct

  
 

 
  

					
		  	 Novartis wants to be known for being a responsible corporate citizen. We do everything that we can to operate in a manner that is
sustainable – economically, socially and environmentally in the best interests of the long-term success of our enterprise and its stakeholders.
  

In support of this goal, Novartis firmly supports the principles of the United Nations Global Compact and the Pharmaceutical Industry Principles for
Responsible Supply Chain Management, and we are committed to reflecting these in our business principles and practices.
  
 www.novartis.com/supplier
	 	

  

					
		 	

	  	Version 2.0, April 2007

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

 Supply Chain Principles | 2 
  
 Pharmaceutical Industry Principles for Responsible Supply Chain Management 

This document outlines the Pharmaceutical Industry Principles for Responsible Supply Chain Management (the “Principles”) for ethics, labor,
health and safety, environment and related management systems. The Principles may be voluntarily supported by any business in the pharmaceutical industry. 
 Companies supporting the Principles: 
  

	•	 	 Will integrate and apply these Principles in a manner consistent with their own supplier programs. 

 

	•	 	 Believe that society and business are best served by responsible business behaviors and practices. Fundamental to this belief is the understanding that
a business must, at a minimum, operate in full compliance with all applicable laws, rules and regulations. 

  

	•	 	 Are aware of differences in culture and the challenges associated with interpreting and applying these Principles globally. While companies supporting
the Principles believe that what is expected is universal, it is understood that the methods for meeting these expectations may be different and must be consistent with the laws, values and cultural expectations of the different societies in the
world. 

  

	•	 	 Believe the Principles are best implemented through a continual improvement approach that advances supplier performance over time.

  
 2 

 Supply Chain Principles | 3 
  
 Ethics 
 Suppliers
shall conduct their business in an ethical manner and act with integrity. The ethics elements include: 
 1. Business Integrity and Fair
Competition 
 All corruption, extortion and embezzlement are prohibited. Suppliers shall not pay or accept bribes or participate in other
illegal inducements in business or government relationships. Suppliers shall conduct their business consistent with fair and vigorous competition and in compliance with all applicable anti-trust laws. Suppliers shall employ fair business practices,
including accurate and truthful advertising. 
 2. Identification of Concerns 
 All workers should be encouraged to report concerns or illegal activities in the workplace, without threat of reprisal, intimidation or harassment. Suppliers shall investigate and take corrective action
if needed. 
 3. Animal Welfare 

Animals shall be treated humanely, with pain and stress minimized. Animal testing should be performed after consideration to replace animals, reduce the
numbers of animals used or refine procedures to minimize distress. Alternatives should be used wherever scientifically valid and acceptable to regulators. 
 4. Privacy 
 Suppliers shall safeguard and make only proper use of confidential information
to ensure that company, worker and patient privacy rights are protected. 

  
 3 

 Supply Chain Principles | 4 
  
 Labor 
 Suppliers
shall be committed to uphold the human rights of workers and to treat them with dignity and respect. The labor elements include: 
 1. Freely
Chosen Employment 
 Suppliers shall not use forced, bonded, indentured or involuntary prison labor. 

2. Child Labor and Young Workers 

Suppliers shall not use child labor. The employment of young workers below the age of 18 shall only occur in non-hazardous work and when young workers are
above a country’s legal age for employment or the age established for completing compulsory education. 
 3. Non-Discrimination

 Suppliers shall provide a workplace free of harassment and discrimination. Discrimination for reasons such as race, color, age, gender,
sexual orientation, ethnicity, disability, religion, political affiliation, union membership or marital status is not condoned. 
 4. Fair
Treatment 
 Suppliers shall provide a workplace free of harsh and inhumane treatment, including any sexual harassment, sexual abuse,
corporal punishment, mental or physical coercion or verbal abuse of workers and no threat of any such treatment. 
 5. Wages, Benefits and
Working Hours 
 Suppliers shall pay workers according to applicable wage laws, including minimum wages, overtime hours and mandated
benefits. 
 Suppliers shall communicate with the worker the basis on which they are being compensated in a timely manner. Suppliers are also
expected to communicate with the worker whether overtime is required and the wages to be paid for such overtime. 
 6. Freedom of Association

 Open communication and direct engagement with workers to resolve workplace and compensation issues is encouraged. Suppliers shall respect
the rights of workers, as set forth in local laws, to associate freely, join or not join labor unions, seek representation and join workers’ councils. Workers shall be able to communicate openly with management regarding working conditions
without threat of reprisal, intimidation or harassment. 

  
 4 

 Supply Chain Principles | 5 
  
 Health and Safety 

Suppliers shall provide a safe and healthy working environment, including for any company-provided living quarters. The health and safety elements
include: 
 1. Worker Protection 

Suppliers shall protect workers from over exposure to chemical, biological and physical hazards, physically demanding tasks in the workplace and in any
company-provided living quarters. 
 2. Process Safety 
 Suppliers shall have programs in place to prevent or mitigate catastrophic releases of chemicals. 

3. Emergency Preparedness and Response 

Suppliers shall identify and assess emergency situations in the workplace and any company-provided living quarters, and minimize their impact by
implementing emergency plans and response procedures. 
 4. Hazard Information 
 Safety information relating to hazardous materials – including pharmaceutical compounds and pharmaceutical intermediate materials – shall be available to educate, train and protect workers from
hazards. 

  
 5 

 Supply Chain Principles | 6 
  
 Environment 

Suppliers shall operate in an environmentally responsible and efficient manner, and they shall minimize adverse impacts on the environment. Suppliers are
encouraged to conserve natural resources, to avoid the use of hazardous materials where possible and to engage in activities that reuse and recycle. The environmental elements include: 
 1. Environmental Authorizations 
 Suppliers shall comply with all applicable environmental
regulations. All required environmental permits, licenses, information registrations and restrictions shall be obtained and their operational and reporting requirements followed. 
 2. Waste and Emissions 
 Suppliers shall have systems in place to ensure the safe handling,
movement, storage, recycling, reuse or management of waste, air emissions and wastewater discharges. Any waste, wastewater or emissions with the potential to adversely impact human or environmental health shall be appropriately managed, controlled
and treated prior to release into the environment. 
 3. Spills and Releases 
 Suppliers shall have systems in place to prevent and mitigate accidental spills and releases to the environment. 

  
 6 

 Supply Chain Principles | 7 
  
 Management Systems 

Suppliers shall use management systems to facilitate continual improvement and compliance with the expectations of these principles. The management
systems elements include: 
 1. Commitment and Accountability 
 Suppliers shall demonstrate commitment to the concepts described in this document by allocating appropriate resources. 
 2. Legal and Customer Requirements 
 Suppliers shall identify and comply with applicable
laws, regulations, standards and relevant customer requirements. 
 3. Risk Management 

Suppliers shall have mechanisms to determine and manage risks in all areas addressed by this document. 

4. Documentation 
 Suppliers shall
maintain documentation necessary to demonstrate conformance with these expectations and compliance with applicable regulations. 
 5.
Training and Competency 
 Suppliers shall have a training program that achieves an appropriate level of knowledge, skills and abilities in
management and workers to address these expectations. 
 6. Continual Improvement 

Suppliers are expected to continually improve by setting performance objectives, executing implementation plans and taking necessary corrective actions
for deficiencies identified by internal or external assessments, inspections and management reviews. 

  
 7 

  
 

 
 Corporate Citizenship Guideline # 5 
 Third Party Management 
  
 

 

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 1 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 8 

 

 
  
  

			
		  	  
 Purpose and References

		
	1. Purpose of this guideline	  	 This Guideline was issued by the Novartis Group Executive Committee (ECN) on August 21, 2003. In line with the CC Policy and Guideline
#1, paragraph 10, it sets forth the Corporate Citizenship criteria which Novartis takes into account in selecting its suppliers and service providers (Third Parties).
  

Novartis supports the “Pharmaceutical Supply Chain initiative” (PSCI) (see also www.pharmaceuticalsupplychain.org). This guideline explains how
Novartis integrates these principles in its supplier program.

		
	2. Reference to Novartis Third Party Code of Conduct	  	To communicate the expectations from the Third Parties, Novartis has established a “Third Party Code of Conduct”, which specifies these expectations and is in line with
the “Pharmaceutical Industry Principles for Responsible Supply Chain Management”.
		
	3. Reference to Guidance Note 5.1	  	 This Guideline is accompanied by the Guidance Note 5.1 “Practical Implementation Recommendations for Corporate Citizenship in Third
Party Relations” which provides details for: selecting evaluation criteria; creating a dialogue on Corporate Citizenship principles through the use of standard questionnaires; performing assurance visits; and providing special support in
certain situations that Novartis deems warranted.
  

Responsibilities

		
	4. Divisions, Business Units, Novartis International	  	The Division Heads, Heads of Consumer Health Business Units, and the Head of Corporate Services are responsible for proper implementation of this Guideline within their units. They
shall nominate a Third Party Officer (3PO) within their units. By preference, the 3PO shall be the head of a purchasing department or the head of a supply chain function.
		
	5. Third Party Officer’s Responsibility	  	The 3PO shall ensure that for all purchasing operations within his/her unit, a “Third Party Management Process” is in place which covers purchasing operations in all
affiliates and sites. The 3PO is the driving force within the unit to implement this Guideline (= CC5), including recruitment and training of local 3PM’s and ensuring high quality of data and risk assessment associated to the CC5
process.
		
	6. Third Party Management	  	In each local operational unit a responsible “Third Party Manager” (3PM) assures that responsibilities and processes are established, maintained and implemented. It should
address: (1) the process by which Third Parties are identified, selected and contracted; and (2) the manner in which support by relevant functions (e.g. HR, HSE, Legal, Compliance Officers) is provided.
		
	7. Ownership and Operating Responsibility	  	 This Guideline and its associated Guidance Note # 5.1 are owned and maintained by Group Purchasing.

 
 The Chief Procurement Officer shall, together with the 3PO’s ensure consistent
application within Novartis as well as periodical reviews, as required. This is achieved by regular 3PO meetings, chaired by the Chief Procurement Officer. The 3PO’s also approve SOP’s for consistent management of CC5.

 
 Proper management of CC5 is supported by a central database (GLOSUD), which is
maintained by Group Purchasing, the data being entered by all Divisions, Business Units or Novartis International.

		  	  
 Principles & Expectations

		
	8. Our principles and expectations	  	Novartis gives preference to Third Parties that share the societal and environmental values required by the Global Compact. As a consequence, Third Parties are expected to comply
with minimum standard requirements concerning ethics, labor, health, safety and environmental protection and management systems, specified in the Novartis Third Party Code of Conduct and set forth in paragraphs 9 – 13 of this
Guideline.

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 2 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 9 

 

 
  

			
		  	  
 Compliance with the Third Party Code of Conduct shall be assessed
before contracting with any Third Party and shall constitute an element of equal importance among other evaluation criteria such as price or quality.
  

While we recognize that there are different legal and cultural environments in which our Business Partners operate throughout the world, it is
Novartis’ intention to work collaboratively with Third Parties to achieve these goals on a long term and sustainable basis.

		
	9. Ethics	  	Suppliers shall conduct their business in an ethical manner and act with integrity. The ethics elements include:
		  	  
 1. Business Integrity and Fair Competition

 
 All corruption, extortion and embezzlement are prohibited. Suppliers shall not pay or
accept bribes or participate in other illegal inducements in business or government relationships. Suppliers shall conduct their business consistent with fair and vigorous competition and in compliance with all applicable anti-trust laws. Suppliers
shall employ fair business practices including accurate and truthful advertising.

		  	  
 2. Identification of Concerns

 
 All workers should be encouraged to report concerns or illegal activities in the
workplace without threat of reprisal, intimidation or harassment. Suppliers shall investigate and take corrective action if needed.

		  	  
 3. Animal Welfare

 
 Animals shall be treated humanely with pain and stress minimized. Animal testing
should be performed after consideration to replace animals, to reduce the numbers of animals used, or to refine procedures to minimize distress. Alternatives should be used wherever these are scientifically valid and acceptable to
regulators.

		  	  
 4. Privacy

 
 Suppliers shall safeguard and make only proper use of confidential information to
ensure that company, worker, and patient privacy rights are protected.

		
	10. Labor	  	Suppliers shall be committed to uphold the human rights of workers and to treat them with dignity and respect. The Labor elements include:
		  	  
 1. Freely Chosen Employment

 
 Suppliers shall not use forced, bonded or indentured labor or involuntary prison
labor.

		  	  
 2. Child Labor and Young Workers

 
 Suppliers shall not use child labor. The employment of young workers below the age of
18 shall only occur in non hazardous work and when young workers are above a country’s legal age for employment or the age established for completing compulsory education.

		  	  
 3. Non-Discrimination

 
 Suppliers shall provide a workplace free of harassment and discrimination.
Discrimination for reasons such as race, color, age, gender, sexual orientation, ethnicity, disability, religion, political affiliation, union membership or marital status is not condoned.

		  	  
 4. Fair Treatment

 
 Suppliers shall provide a workplace free of harsh and inhumane treatment, including
any sexual harassment, sexual abuse, corporal punishment, mental or physical coercion or verbal abuse of workers and no threat of any such treatment.

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 3 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 10 

 

 
  

			
		  	 5. Wages, Benefits and Working Hours
  

Suppliers shall pay workers according to applicable wage laws, including minimum wages, overtime hours and mandated benefits.

 
 Suppliers shall communicate with the worker the basis on which they are being
compensated in a timely manner. Suppliers are also expected to communicate with the worker whether overtime is required and the wages to be paid for such overtime.

		  	  
 6. Freedom of Association

 
 Open communication and direct engagement with workers to resolve workplace and
compensation issues is encouraged.
  
 Suppliers shall respect the rights of
workers, as set forth in local laws, to associate freely, join or not join labor unions, seek representation and join workers’ councils. Workers shall be able to communicate openly with management regarding working conditions without threat of
reprisal, intimidation or harassment.

		
	11. Health and Safety	  	Suppliers shall provide a safe and healthy working environment, including for any company provided living quarters. The Health and Safety elements include:
		  	  
 1. Worker Protection

 
 Suppliers shall protect workers from over exposure to chemical, biological, physical
hazards and physically demanding tasks in the work place and in any company provided living quarters.

		  	  
 2. Process Safety

 
 Suppliers shall have programs in place to prevent or mitigate catastrophic releases
of chemicals.
  
 3. Emergency Preparedness and Response

 
 Suppliers shall identify and assess emergency situations in the workplace and any
company provided living quarters, and to minimize their impact by implementing emergency plans and response procedures.

		  	  
 4. Hazard Information

 
 Safety information relating to hazardous materials – including pharmaceutical
compounds and pharmaceutical intermediate materials – shall be available to educate, train, and protect workers from hazards.

		
	12. Environment	  	Suppliers shall operate in an environmentally responsible and efficient manner and they shall minimize adverse impacts on the environment. Suppliers are encouraged to conserve
natural resources, to avoid the use of hazardous materials where possible and to engage in activities that reuse and recycle. The environmental elements include:
		  	  
 1. Environmental Authorizations

 
 Suppliers shall comply with all applicable environmental regulations. All required
environmental permits, licenses, information registrations and restrictions shall be obtained and their operational and reporting requirements followed.

		  	  
 2. Waste and Emissions

 
 Suppliers shall have systems in place to ensure the safe handling, movement, storage,
recycling, reuse, or management of waste, air emissions and wastewater discharges. Any waste, wastewater or emissions with the potential to adversely impact human or environmental health shall be appropriately managed, controlled and treated prior
to release into the environment.

		  	  
 3. Spills and Releases

 
 Suppliers shall have systems in place to prevent and mitigate accidental spills and
releases to the environment.

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 4 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 11 

 

 
  

			
	13. Management Systems	  	Suppliers shall use management systems to facilitate continual improvement and compliance with the expectations of these principles. The management system elements
include:
		  	  
 1. Commitment and Accountability

 
 Suppliers shall demonstrate commitment to the concepts described in this document by
allocating appropriate resources.

		  	  
 2. Legal and Customer Requirements

 
 Suppliers shall identify and comply with applicable laws, regulations, standards and
relevant customer requirements.

		  	  
 3. Risk Management

 
 Suppliers shall have mechanisms to determine and manage risks in all areas addressed
by this document.

		  	  
 4. Documentation

 
 Suppliers shall maintain documentation necessary to demonstrate conformance with
these expectations and compliance with applicable regulations.

		  	  
 5. Training and Competency

 
 Suppliers shall have a training program that achieves an appropriate level of
knowledge, skills and abilities in management and workers to address these expectations.

		  	  
 6. Continual Improvement

 
 Suppliers are expected to continually improve by setting performance objectives,
executing implementation plans and taking necessary corrective actions for deficiencies identified by internal or external assessments, inspections, and management reviews.

		  	  
 Novartis Management Process

 

	14. Information	  	Third Parties shall be made aware of the Third Party Code of Conduct and the compliance requirements to qualify for a business relationship with Novartis.
		
	15. Clause in contract	  	Relevant contracts shall include explicit reference to the Third Party Code of Conduct and the compliance requirement to qualify for a business relationship with
Novartis.
		
	16. Classification of third parties	  	All Third Parties will be classified in one of five categories according to the industry they are in, the country in which they operate, their annual revenues with Novartis and the
judgment of the buyer/3PM regarding the level of risks associated with their operations.
		
	17. Class 0	  	The following Third Parties are out of scope and classified as Class 0: Medical doctors, Key opinion leaders, government agencies and inter-company transfers.
		
	18. Class 1	  	Third Parties classified as non-critical (Class 1), shall be made aware of the Third Party Code of Conduct and the fact that Novartis gives preference to Third Parties that comply
with these Principles or substantially similar standards.
		
	19. Class 2	  	Third Parties classified as critical (Class 2) shall be asked explicitly for information about their level of compliance with the Third Party Code of Conduct and to provide basic
corporate citizenship related information about their business (“self-assessment”). To this end Novartis provides a form to be used as is, or to be completed with questions of specific interest to the Business unit.
		
	20. Class 3 or 4	  	For Third Parties classified as very critical (Class 3 or 4), Novartis shall seek additional assurance of their commitment to and implementation of the Third Party Code of Conduct.
This assurance may include a request by Novartis to conduct assurance visits to the Third Party site in order to learn about the level of

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 5 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 12 

 

 
  

			
		  	compliance with the Third Party Code of Conduct. For Third Parties using Novartis materials, processes, techniques, or know-how, e.g. toll or contract manufacturers, an assurance
visit is mandatory for approval. As a basis for preparation and conducting the assurance visit, Novartis provides a questionnaire to be used as is, or to be completed with questions of specific interest to the unit. Follow-up visits should be
conducted on a regular basis. Novartis shall maintain the data received during this process for ongoing compliance evaluations.
		
	21. Improvement programs and special support (Class 4)	  	In cases where the results of the assurance visits and inquiries are unsatisfactory, Novartis may assist the Third Party in developing an improvement program designed to raise the
level of compliance with the Third Party Code of Conduct. If concerns persist regarding the commitment or capability of the Third Party to improve of its own accord, a decision must be made at Corporate Steering Committee level as to whether special
support should be provided (= Class 4) or the contract terminated. If an agreed improvement program is not completed within three years, or if the respective audit results are not satisfactory, then the contract shall be terminated.
		
	22. Assessment process for known Third Parties	  	In cases where, in view of a previous or an ongoing business relationship, sufficient information about a specific Third Party is already available, the assessment process can be
simplified and reduced to the level necessary to ascertain the Third Party’s compliance with the Third Party Code of Conduct. Such deviations from the standard assessment process must be justified and documented and must be approved by the
3PO.
		  	  
 Reporting Criteria & Measurements

		
	23. Reporting to Senior Management	  	 The Chief Procurement Officer is responsible for coordination of internal reporting on CC5 implementation, including the establishment
of appropriate KPI’s for managing continuous improvement.
  
 The
3PO’s are responsible for reporting the KPI achievements to the Executive Committee of their unit and to the Chief Procurement Officer.

		
	24. Status of compliance and impact	  	A qualitative and quantitative assessment of the status of compliance and impact within the units is part of the KPI’s.
		
	25. Reporting	  	The Chief Procurement Officer is responsible for establishing the format for reporting, the frequency, and the recipients of the reporting.
		  	  
 Escalation procedure

		
	26. Termination of Third Party relationship	  	Indications for termination of a contractual relationship (see above 21) are escalated by the 3PM through the 3PO to the Division Head(s) or Head(s) of Consumer Health Business
Unit(s). If the decision to terminate the relationship is not unanimous, the Chief Procurement Officer will bring the controversy to the attention of the CC Steering Committee. The Chairman of the CC Steering Committee will raise the controversy at
the ECN.
		
	27. Non compliance	  	Material non compliance of a business unit to the CC5 process as described in the relevant guidelines and SOP’s, as well as continual failure to meet the KPI’s is
escalated by the Chief Procurement Officer to the CC Steering Committee. The Chairman of the CC Steering Committee will raise material non compliance at the ECN.

  

			
	Version 2.2, July 4, 2007:	  	 Proposed Changes to Article 7 (Ownership and Operating Responsibility)
 Proposed Changes to Articles 23-27 (Reporting; Escalation)
  
 Circular approval by the 3PO’s July 4, 2007
 Final Approval with modification of Articles
26/27 by Head Corporate Services July 10, 2007

  

					
	Corporate Citizenship Guideline 5	  	
	Initial Version:	  	approved by ECN August 21, 2003	  	Page 6 of 6
	Version 2.2:	  	approved by 3PO’s and Head Corporate Services July 10, 2007	  	

  
 13 

 EXHIBIT E 
 Global Laboratory Notebook Guidelines 
 Laboratory notebooks shall be
issued and used in substantial compliance with the following: 
 This laboratory notebook is to be used to make a systematic, permanent record
of all experimental work, and to record ideas or concepts which might be used to support patents, product registrations, and other activities. No other form of notebook may be used to record experimental observations Loose-leaf binders may only be
used to store accessory data which cannot be pasted into the notebook. Provide sufficient experimental detail to allow an independent scientist with basic skills in the appropriate discipline to reproduce the work. 

The book is issued to you and it is your personal responsibility to ensure its confidentiality and physical security at all times until it is handed over
to the Research Archive for permanent storage. This will usually mean that the book is to remain on [Party]’s premises and that any relocation must be properly authorized. This Laboratory Notebook must be submitted to the local Research Archive
for microfilming/scanning and safe storage ASAP after completion at the latest, 3 months after the last entry ALL lab notebooks irrespective of whether completed or only partially filled must be closed out and returned to the Research Archive one
year after issue, or immediately if you relocate to a different site, or leave [Party]. 

 

 General 
 On receipt of a new notebook immediately ensure that the identification panel is correctly filled in, and then register your signature, initials, and employee number in the “Table of Contributors and
Signatures”. 
 Keep records clear, objective, accurate, and ensure they are dated unambiguously. Signatures must NEVER be back-dated or
otherwise falsified. 
 Write preferably using a ball point pen in permanent black, waterproof ink. Do not use pencil, or ink which may run if
wet 
 Whenever practicable, record directly into the lab notebook 
 Handwriting must be legible to be of evidential value. 
 Use pages in a chronological, sequential
order. Do not leave empty spaces or empty pages. Cross through empty space on partly used pages with a diagonal line or X. 
 NEVER remove pages
from the book and do not obscure the printed page numbers. Keep all entries within the printed margins. 
 When making corrections cross out
with a single line. The original entry must remain readable. 
 ALL corrections and additions must be initialed and dated. Explain corrections
if they change the interpretation of the experiment Corrections may normally only be made by the original author. 
 Books which are
discontinued but not filled must be properly terminated by writing “Book Discontinued – No Entries Beyond This Page” on the first empty page. This final page must be signed by the author and witnessed. 

NEVER make negative or derogatory statements about yourself, your

 
Witnesses must record their signature, initials and employee number in the “Table of Contributors and Signatures” the first time they witness each book 

Only permanent NIBR employees can be witnesses. 

Indexing 
 Lab notebooks must
contain a “Table of Contents” which must contain sufficient information to facilitate easy review of the book contents by an independent reader. 
 Define all abbreviations used in the “Table of Abbreviations”. 
 Reference all accessory
records not pasted into the notebook on page XX. 
 Use a uniform format for lab notebook references – this should comprise the book number
(mandatory) + page number (mandatory) + line number (optional) e g E-0000-56(-35). 
 Structure 

Structure lab notebook entries to assist interpretation by independent readers. Use headings where appropriate. The description of experiments must
include (but not necessarily be limited to) at least the following items – 
  

	•	 	 Date and Title (when the page was started) 

  

	•	 	 Materials – Record the source and batch numbers of key materials 

 

	•	 	 Method – Provide sufficient experimental detail to allow an independent worker with basic skills in the same scientific discipline to
reproduce the work. Record all deviations from standard protocols however small. 

  

	•	 	 Results – Record ALL experiments and findings, even those which work, or Novartis products in the notebook.

 

  

Confidential materials omitted and filed separately with the Securities and Exchange 

Commission. Asterisks denote such omission. 

 Accessory Data 
 Paste accessory data into the book with a permanent adhesive. Sign or initial over the edges of sheets pasted into the book. Do not overlay or fold material pasted into the book. 

Accessory data which is too bulky to paste into the book must be stored in files or binders which are properly labeled and bi-directionally cross
referenced. Files or binders must be specifically identified and their labels should contain a cross reference to the laboratory notebook number. Key items of accessory data must be signed and dated. Electronic accessory data helpful for the
interpretation of the experiment should be digitally signed and stored 
 Authorship and Signatures 

Entries should wherever possible be made only by the person to whom the book is issued. In exceptional cases where multiple authorship is unavoidable, it
must be clear who recorded which entries and when. Multiple authorship should be defined in the “Table of Contributors and Signatures”. 
 Sign and date each page as soon as it is completed (including any blank pages that are crossed out) 
 Completed pages (including crossed out blank pages) must be witnessed and dated within 2 weeks of the author’s signature. 
 A witness should be capable of appreciating the work recorded, and for patent protection, the witness should not have the potential to become a co-inventor of the work being witnessed.

 
may be considered to have “not worked” or be “negative”, however describe these as not having returned the expected results, or if a reaction, as not having produced the
desired product. 
  

	•	 	 Interpretation – must be objective and supported by the experimental data. Avoid the use of subjective comments and opinions such as
“obvious”, “routine”, “clearly”. 

 Ideas 

Record novel concepts and ideas. Be as specific as possible e.g. suggest compounds to be made, their possible utility, and proposed synthetic routes or
test methods. Ideas for novel concepts must be signed, and promptly witnessed to be of value. 
 Confidentiality and Physical Security

 The notebook remains the property of [Party] at all times and will contain confidential, proprietary, and trade secret information
that must not be disclosed to unauthorized persons. 
 Notebooks must be kept locked in fire-resistant storage when not in use. 

Notebooks must not be removed from [Party] premises unless appropriate authorization has been obtained. 

Copies of laboratory notebook pages should be made only if absolutely necessary. Copies must be treated as confidential material like the book itself.
Paper copies must be destroyed according to [Party] standard practices (i.e. shredding, diamond cutting, etc.) as soon as they have served their purpose.

 

  
 2Exhibit 10.7

 Exhibit 10.7 
 FORM OF INDEMNIFICATION AGREEMENT 
 (For Directors) 

This Indemnification Agreement (“Agreement”) is made as of
                     by and between Enanta Pharmaceuticals, Inc., a Delaware corporation (the “Company”),
[                    , a Delaware limited partnership (the “Fund”),]1 and                 
(“Indemnitee”). This Agreement supersedes and replaces any and all previous Agreements between the Company and Indemnitee covering the subject matter of this Agreement. 

RECITALS 

A. The Board of Directors of the Company (the “Board”) has determined that, in order to attract and retain qualified
individuals, the Company will attempt to maintain on an ongoing basis, at its sole expense, liability insurance to protect persons serving the Company and its subsidiaries from certain liabilities. Although the furnishing of such insurance has been
a customary and widespread practice among United States-based corporations and other business enterprises, the Company believes that, given current market conditions and trends, such insurance may be available to it in the future only at higher
premiums and with more exclusions. At the same time, directors, officers, and other persons in service to corporations or business enterprises are being increasingly subjected to expensive and time-consuming litigation relating to, among other
things, matters that traditionally would have been brought only against the Company or business enterprise itself. The Certificate of Incorporation of the Company (the “Certificate of Incorporation”) requires indemnification of the
officers and directors of the Company. Indemnitee may also be entitled to indemnification pursuant to the General Corporation Law of the State of Delaware (the “DGCL”). The Certificate of Incorporation and the DGCL expressly provide that
the indemnification provisions set forth therein are not exclusive, and thereby contemplate that contracts may be entered into between the Company and members of the board of directors, officers and other persons with respect to indemnification.

 B. The uncertainties relating to such insurance and to indemnification have increased the difficulty of attracting and
retaining such persons. 
 C. The Board has determined that the increased difficulty in attracting and retaining such persons is
detrimental to the best interests of the Company and its stockholders and that the Company should act to assure such persons that there will be increased certainty of such protection in the future. 

D. It is reasonable, prudent and necessary for the Company contractually to obligate itself to indemnify, and to advance expenses on
behalf of, such persons to the fullest extent permitted by applicable law so that they will serve or continue to serve the Company free from undue concern that they will not be so indemnified; 

 

	1 	Included if the Indemnitee is affiliated with a fund or other entity that provides indemnification to the Indemnitee. 

 E. This Agreement is a supplement to and in furtherance of the Certificate of Incorporation
and any resolutions adopted pursuant thereto, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder. 
 F. Indemnitee does not regard the protection available under the Certificate of Incorporation and insurance as adequate in the present circumstances, and may not be willing to serve as an officer or
director without adequate protection, and the Company desires Indemnitee to serve in such capacity. Indemnitee is willing to serve, continue to serve and to take on additional service for or on behalf of the Company on the condition that he be so
indemnified. 
 [G. Indemnitee is a representative of the Fund, and has certain rights to indemnification and/or insurance
provided by the Fund which Indemnitee and the Fund intend to be secondary to the primary obligation of the Company to indemnify Indemnitee as provided herein, with the Company’s acknowledgement and agreement to the foregoing being a material
condition to Indemnitee’s willingness to serve on the Board.]2 
 NOW, THEREFORE, in consideration of the premises and the covenants contained
herein, the Company and Indemnitee do hereby covenant and agree as follows: 
 Section 1. Services to the Company.
Indemnitee agrees to serve as a [director] [officer] of the Company. Indemnitee may at any time and for any reason resign from such position (subject to any other contractual obligation or any obligation imposed by operation of law), in which event
the Company shall have no obligation under this Agreement to continue Indemnitee in such position. This Agreement shall not be deemed an employment contract between the Company (or any of its subsidiaries or any Enterprise) and Indemnitee.
Indemnitee specifically acknowledges that Indemnitee’s employment with the Company (or any of its subsidiaries or any Enterprise), if any, is at will, and the Indemnitee may be discharged at any time for any reason, with or without cause,
except as may be otherwise provided in any written employment contract between Indemnitee and the Company (or any of its subsidiaries or any Enterprise), other applicable formal severance policies duly adopted by the Board, or, with respect to
service as a director or officer of the Company, by the Certificate of Incorporation, the Company’s By-laws, and the DGCL. The foregoing notwithstanding, this Agreement shall continue in force after Indemnitee has ceased to serve as a
[director] [officer] of the Company, as provided in Section 16 hereof. 
 Section 2. Definitions. As used in
this Agreement: 
 (a) References to “agent” shall mean any person who is or was a director, officer, or employee of
the Company or a subsidiary of the Company or other person authorized by the Company to act for the Company, to include such person serving in such capacity as a director, officer, employee, fiduciary or other official of another corporation,
partnership, limited liability company, joint venture, trust or other enterprise at the request of, for the convenience of, or to represent the interests of the Company or a subsidiary of the Company. 

 

	2 	This recital should be included if the Indemnitee is affiliated with a fund or other entity that provides indemnification to the Indemnittee. 

  
 2 

 (b) A “Change in Control” shall be deemed to occur upon the earliest to occur
after the date of this Agreement of any of the following events: 
 i. Acquisition of Stock by Third Party. Any Person (as
defined below) is or becomes the Beneficial Owner (as defined below), directly or indirectly, of securities of the Company representing fifteen percent (15%) or more of the combined voting power of the Company’s then outstanding securities
unless the change in relative Beneficial Ownership of the Company’s securities by any Person results solely from a reduction in the aggregate number of outstanding shares of securities entitled to vote generally in the election of directors;

 ii. Change in Board of Directors. During any period of two (2) consecutive years (not including any period prior to the
execution of this Agreement), individuals who at the beginning of such period constitute the Board, and any new director (other than a director designated by a person who has entered into an agreement with the Company to effect a transaction
described in Sections 2(b)(i), 2(b)(iii) or 2(b)(iv)) whose election by the Board or nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds of the directors then still in office who either were
directors at the beginning of the period or whose election or nomination for election was previously so approved, cease for any reason to constitute at least a majority of the members of the Board; 

iii. Corporate Transactions. The effective date of a merger or consolidation of the Company with any other entity, other than a merger
or consolidation which would result in the voting securities of the Company outstanding immediately prior to such merger or consolidation continuing to represent (either by remaining outstanding or by being converted into voting securities of the
surviving entity, or its ultimate parent, as applicable) more than 51% of the combined voting power of the voting securities of the surviving entity (or its ultimate parent, as applicable) outstanding immediately after such merger or consolidation
and with the power to elect at least a majority of the board of directors or other governing body of such surviving entity (or it ultimate parent, as applicable); 
 iv. Liquidation or Sale of Assets. The approval by the stockholders of the Company of a complete liquidation of the Company or an agreement for the sale or disposition by the Company of all or
substantially all of the Company’s assets; and 
 v. Other Events. There occurs any other event of a nature that would be
required to be reported in response to Item 6(e) of Schedule 14A of Regulation 14A (or a response to any similar item on any similar schedule or form) promulgated under the Exchange Act (as defined below), whether or not the Company is then
subject to such reporting requirement. 
 For purposes of this Section 2(b), the following terms shall have the following meanings:

 (A) “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended from time to time.

 (B) “Person” shall have the meaning as set forth in Sections 13(d) and 14(d) of the Exchange Act;
provided, however, 

  
 3 

 
that Person shall exclude (i) the Company, (ii) any trustee or other fiduciary holding securities under an employee benefit plan of the Company, and (iii) any corporation owned,
directly or indirectly, by the stockholders of the Company in substantially the same proportions as their ownership of stock of the Company. 
 (C) “Beneficial Owner” shall have the meaning given to such term in Rule 13d-3 under the Exchange Act; provided, however, that Beneficial Owner shall exclude any Person otherwise becoming a
Beneficial Owner by reason of the stockholders of the Company approving a merger of the Company with another entity. 
 (c)
“Corporate Status” describes the status of a person as a current or former director or officer of the Company or as a current or former director, manager, partner, officer, employee, agent or trustee of any other enterprise which such
person is or was serving at the request of the Company. 
 (d) “Disinterested Director” shall mean a director of the
Company who is not and was not a party to the Proceeding in respect of which indemnification is sought by Indemnitee. 
 (e)
“Enterprise” shall mean the Company and any other corporation, limited liability company, partnership, joint venture, trust or other enterprise of which Indemnitee is or was serving at the request of the Company as a director, officer,
trustee, partner, managing member, employee, agent or fiduciary. 
 (f) “Expenses” shall include all reasonable
attorneys’ fees, retainers, court costs, transcript costs, fees of experts and other professionals, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees, any federal,
state, local or foreign taxes imposed on Indemnitee as a result of the actual or deemed receipt of any payments under this Agreement, ERISA excise taxes and penalties, and all other disbursements or expenses of the types customarily incurred in
connection with prosecuting, defending, preparing to prosecute or defend, investigating, being or preparing to be a witness in, or otherwise participating in, a Proceeding. Expenses also shall include (i) Expenses incurred in connection with
any appeal resulting from any Proceeding, including without limitation the premium, security for, and other costs relating to any cost bond, supersedeas bond, or other appeal bond or its equivalent, and (ii) for purposes of Section 14(d)
only, Expenses incurred by Indemnitee in connection with the interpretation, enforcement or defense of Indemnitee’s rights under this Agreement, by litigation or otherwise. The parties agree that for the purposes of any advancement of Expenses
for which Indemnitee has made written demand to the Company in accordance with this Agreement, all Expenses included in such demand that are certified by affidavit of Indemnitee’s counsel as being reasonable shall be presumed conclusively to be
reasonable. Expenses, however, shall not include amounts paid in settlement by Indemnitee or the amount of judgments or fines against Indemnitee. 

  
 4 

 (g) “Independent Counsel” shall mean a law firm, or a member of a law firm, that
is experienced in matters of corporation law and neither presently is, nor in the past five years has been, retained to represent: (i) the Company or Indemnitee in any matter material to either such party (other than with respect to matters
concerning the Indemnitee under this Agreement, or of other indemnitees under similar indemnification agreements), or (ii) any other party to the Proceeding giving rise to a claim for indemnification hereunder. Notwithstanding the foregoing,
the term “Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of interest in representing either the Company or Indemnitee in an action to
determine Indemnitee’s rights under this Agreement. The Company agrees to pay the reasonable fees and expenses of the Independent Counsel referred to above and to fully indemnify such counsel against any and all Expenses, claims, liabilities
and damages arising out of or relating to this Agreement or its engagement pursuant hereto. 
 (h) The term
“Proceeding” shall include any threatened, pending or completed action, suit, claim, counterclaim, cross claim, arbitration, mediation, alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or any other
actual, threatened or completed proceeding, whether brought in the right of the Company or otherwise and whether of a civil, criminal, administrative, legislative, or investigative (formal or informal) nature, including any appeal therefrom, in
which Indemnitee was, is or will be involved as a party, potential party, non-party witness or otherwise by reason of the fact that Indemnitee is or was a director or officer of the Company, by reason of any action taken by him (or a failure to take
action by him) or of any action (or failure to act) on his part while acting pursuant to his Corporate Status, in each case whether or not serving in such capacity at the time any liability or Expense is incurred for which indemnification,
reimbursement, or advancement of Expenses can be provided under this Agreement. If the Indemnitee believes in good faith that a given situation may lead to or culminate in the institution of a Proceeding, this shall be considered a Proceeding under
this paragraph. 
 (i) Reference to “other enterprise” shall include employee benefit plans; references to
“fines” shall include any excise tax assessed with respect to any employee benefit plan; references to “serving at the request of the Company” shall include any service as a director, officer, employee or agent of the Company
which imposes duties on, or involves services by, such director, officer, employee or agent with respect to an employee benefit plan, its participants or beneficiaries; and a person who acted in good faith and in a manner he reasonably believed to
be in the best interests of the participants and beneficiaries of an employee benefit plan shall be deemed to have acted in manner “not opposed to the best interests of the Company” as referred to in this Agreement. 

Section 3. Indemnity in Third-Party Proceedings. The Company shall indemnify Indemnitee in accordance with the provisions of
this Section 3 if Indemnitee is, or is threatened to be made, a party to or a participant in any Proceeding, other than a Proceeding by or in the right of the Company to procure a judgment in its favor. Pursuant to this Section 3,
Indemnitee shall be indemnified to the fullest extent permitted by applicable law against all Expenses, judgments, fines and amounts paid in settlement (including all interest, assessments and other charges paid or payable in connection with or in
respect of such Expenses, judgments, fines and amounts paid in settlement) actually and reasonably incurred by Indemnitee or on his behalf in 

  
 5 

 
connection with such Proceeding or any claim, issue or matter therein, if Indemnitee acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of
the Company and, in the case of a criminal Proceeding had no reasonable cause to believe that his conduct was unlawful. The parties hereto intend that this Agreement shall provide to the fullest extent permitted by law for indemnification in excess
of that expressly permitted by statute, including, without limitation, any indemnification provided by the Certificate of Incorporation, the By-laws, vote of its stockholders or disinterested directors or applicable law. 

Section 4. Indemnity in Proceedings by or in the Right of the Company. The Company shall indemnify Indemnitee in accordance
with the provisions of this Section 4 if Indemnitee is, or is threatened to be made, a party to or a participant in any Proceeding by or in the right of the Company to procure a judgment in its favor. Pursuant to this Section 4, Indemnitee
shall be indemnified to the fullest extent permitted by applicable law against all Expenses actually and reasonably incurred by him or on his behalf in connection with such Proceeding or any claim, issue or matter therein, if Indemnitee acted in
good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the Company. No indemnification for Expenses shall be made under this Section 4 in respect of any claim, issue or matter as to which Indemnitee
shall have been finally adjudged by a court to be liable to the Company, unless and only to the extent that the Delaware Court of Chancery (the “Delaware Court”) or any court in which the Proceeding was brought shall determine upon
application that, despite the adjudication of liability but in view of all the circumstances of the case, Indemnitee is fairly and reasonably entitled to indemnification for such expenses as the Delaware Court shall deem proper. 

Section 5. Indemnification for Expenses of a Party Who is Wholly or Partly Successful. Notwithstanding any other provisions
of this Agreement, to the fullest extent permitted by applicable law and to the extent that Indemnitee is a party to (or a participant in) and is successful, on the merits or otherwise, in any Proceeding or in defense of any claim, issue or matter
therein, in whole or in part, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him in connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful, on the merits or
otherwise, as to one or more but less than all claims, issues or matters in such Proceeding, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or on his behalf in connection with or related to each
successfully resolved claim, issue or matter to the fullest extent permitted by law. For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with or without prejudice,
shall be deemed to be a successful result as to such claim, issue or matter. 
 Section 6. Indemnification For Expenses
of a Witness. Notwithstanding any other provision of this Agreement, to the fullest extent permitted by applicable law and to the extent that Indemnitee is, by reason of his Corporate Status, a witness or otherwise asked to participate in any
Proceeding to which Indemnitee is not a party, he shall be indemnified against all Expenses actually and reasonably incurred by him or on his behalf in connection therewith. 
 Section 7. Partial Indemnification. If Indemnitee is entitled under any provision of this Agreement to indemnification by the Company for some or a portion of Expenses, but not, however, for
the total amount thereof, the Company shall nevertheless indemnify Indemnitee for the portion thereof to which Indemnitee is entitled. 

  
 6 

 Section 8. Additional Indemnification. 

(a) Notwithstanding any limitation in Sections 3, 4, or 5, the Company shall indemnify Indemnitee to the fullest extent permitted by
applicable law if Indemnitee is a party to or threatened to be made a party to any Proceeding (including a Proceeding by or in the right of the Company to procure a judgment in its favor) against all Expenses, judgments, fines and amounts paid in
settlement (including all interest, assessments and other charges paid or payable in connection with or in respect of such Expenses, judgments, fines and amounts paid in settlement) actually and reasonably incurred by Indemnitee in connection with
the Proceeding. 
 (b) For purposes of Section 8(a), the meaning of the phrase “to the fullest extent permitted by
applicable law” shall include, but not be limited to: 
 i. to the fullest extent permitted by the provision of the DGCL
that authorizes or contemplates additional indemnification by agreement, or the corresponding provision of any amendment to or replacement of the DGCL, and 
 ii. to the fullest extent authorized or permitted by any amendments to or replacements of the DGCL adopted after the date of this Agreement that increase the extent to which a corporation may indemnify
its officers and directors. 
 Section 9. Exclusions. Notwithstanding any provision in this Agreement, the Company
shall not be obligated under this Agreement to make any indemnification payment in connection with any claim made against Indemnitee: 
 (a) for which payment has actually been made to or on behalf of Indemnitee under any insurance policy or other indemnity provision, except with respect to any excess beyond the amount paid under any
insurance policy or other indemnity provision; or 
 (b) for (i) an accounting of profits made from the purchase and sale
(or sale and purchase) by Indemnitee of securities of the Company within the meaning of Section 16(b) of the Exchange Act (as defined in Section 2(b) hereof) or similar provisions of state statutory law or common law, or (ii) any
reimbursement of the Company by the Indemnitee of any bonus or other incentive-based or equity-based compensation or of any profits realized by the Indemnitee from the sale of securities of the Company, as required in each case under the Exchange
Act (including any such reimbursements that arise from an accounting restatement of the Company pursuant to Section 304 of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”), or the payment to the Company of profits arising
from the purchase and sale by Indemnitee of securities in violation of Section 306 of the Sarbanes-Oxley Act); or 
 (c)
except as provided in Section 14(d) of this Agreement, in connection with any Proceeding (or any part of any Proceeding) initiated by Indemnitee, including any Proceeding (or any part of any Proceeding) initiated by Indemnitee against the
Company or its directors, officers, employees or other indemnitees, unless (i) the Board authorized the Proceeding (or any part of any Proceeding) prior to its initiation or (ii) the Company provides the indemnification, in its sole
discretion, pursuant to the powers vested in the Company under applicable law. 

  
 7 

 Section 10. Advances of Expenses. Notwithstanding any provision of this
Agreement to the contrary (other than Section 14(d)), the Company shall advance, to the extent not prohibited by law, the Expenses incurred by Indemnitee in connection with any Proceeding (or any part of any Proceeding) not initiated by
Indemnitee, and such advancement shall be made within thirty (30) days after the receipt by the Company of a statement or statements requesting such advances from time to time, whether prior to or after final disposition of any Proceeding.
Advances shall be unsecured and interest free. Advances shall be made without regard to Indemnitee’s ability to repay the Expenses and without regard to Indemnitee’s ultimate entitlement to indemnification under the other provisions of
this Agreement. In accordance with Section 14(d), advances shall include any and all reasonable Expenses incurred pursuing an action to enforce this right of advancement, including Expenses incurred preparing and forwarding statements to the
Company to support the advances claimed. The Indemnitee shall qualify for advances upon the execution and delivery to the Company of this Agreement, which shall constitute an undertaking providing that the Indemnitee undertakes to repay the amounts
advanced (without interest) to the extent that it is ultimately determined that Indemnitee is not entitled to be indemnified by the Company. No other form of undertaking shall be required other than the execution of this Agreement. This
Section 10 shall not apply to any claim made by Indemnitee for which indemnity is excluded pursuant to Section 9. 

Section 11. Procedure for Notification and Defense of Claim. 

(a) Indemnitee shall notify the Company in writing of any matter with respect to which Indemnitee intends to seek indemnification or
advancement of Expenses hereunder as soon as reasonably practicable following the receipt by Indemnitee of written notice thereof. The written notification to the Company shall include a description of the nature of the Proceeding and the facts
underlying the Proceeding. To obtain indemnification under this Agreement, Indemnitee shall submit to the Company a written request, including therein or therewith such documentation and information as is reasonably available to Indemnitee and is
reasonably necessary to determine whether and to what extent Indemnitee is entitled to indemnification following the final disposition of such Proceeding. The omission by Indemnitee to notify the Company hereunder will not relieve the Company from
any liability which it may have to Indemnitee hereunder or otherwise than under this Agreement, and any delay in so notifying the Company shall not constitute a waiver by Indemnitee of any rights under this Agreement. The Secretary of the Company
shall, promptly upon receipt of such a request for indemnification, advise the Board in writing that Indemnitee has requested indemnification. 
 (b) The Company will be entitled to participate in the Proceeding at its own expense. 
 Section 12. Procedure Upon Application for Indemnification. 
 (a) Upon
written request by Indemnitee for indemnification pursuant to Section 11(a), a determination, if required by applicable law, with respect to Indemnitee’s entitlement thereto shall be made in the specific case: (i) if a Change in
Control shall have 

  
 8 

 
occurred, by Independent Counsel in a written opinion to the Board, a copy of which shall be delivered to Indemnitee; or (ii) if a Change in Control shall not have occurred, (A) by a
majority vote of the Disinterested Directors, even though less than a quorum of the Board, (B) by a committee of Disinterested Directors designated by a majority vote of the Disinterested Directors, even though less than a quorum of the Board,
(C) if there are no such Disinterested Directors or, if such Disinterested Directors so direct, by Independent Counsel in a written opinion to the Board, a copy of which shall be delivered to Indemnitee or (D) if so directed by the Board,
by the stockholders of the Company; and, if it is so determined that Indemnitee is entitled to indemnification, payment to Indemnitee shall be made within ten (10) days after such determination. Indemnitee shall cooperate with the person,
persons or entity making such determination with respect to Indemnitee’s entitlement to indemnification, including providing to such person, persons or entity upon reasonable advance request any documentation or information which is not
privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee and reasonably necessary to such determination. Any costs or Expenses (including attorneys’ fees and disbursements) incurred by Indemnitee in so
cooperating with the person, persons or entity making such determination shall be borne by the Company (irrespective of the determination as to Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold
Indemnitee harmless therefrom. The Company promptly will advise Indemnitee in writing with respect to any determination that Indemnitee is or is not entitled to indemnification, including a description of any reason or basis for which
indemnification has been denied. 
 (b) In the event the determination of entitlement to indemnification is to be made by
Independent Counsel pursuant to Section 12(a) hereof, the Independent Counsel shall be selected as provided in this Section 12(b). If a Change in Control shall not have occurred, the Independent Counsel shall be selected by the Board, and
the Company shall give written notice to Indemnitee advising him of the identity of the Independent Counsel so selected. If a Change in Control shall have occurred, the Independent Counsel shall be selected by Indemnitee (unless Indemnitee shall
request that such selection be made by the Board, in which event the preceding sentence shall apply), and Indemnitee shall give written notice to the Company advising it of the identity of the Independent Counsel so selected. In either event,
Indemnitee or the Company, as the case may be, may, within ten (10) days after such written notice of selection shall have been given, deliver to the Company or to Indemnitee, as the case may be, a written objection to such selection;
provided, however, that such objection may be asserted only on the ground that the Independent Counsel so selected does not meet the requirements of “Independent Counsel” as defined in Section 2 of this Agreement, and
the objection shall set forth with particularity the factual basis of such assertion. Absent a proper and timely objection, the person so selected shall act as Independent Counsel. If such written objection is so made and substantiated, the
Independent Counsel so selected may not serve as Independent Counsel unless and until such objection is withdrawn or the Delaware Court has determined that such objection is without merit. If, within twenty (20) days after the later of
submission by Indemnitee of a written request for indemnification pursuant to Section 11(a) hereof and the final disposition of the Proceeding, no Independent Counsel shall have been selected and not objected to, either the Company or
Indemnitee may petition the Delaware Court for resolution of any objection which shall have been made by the Company or Indemnitee to the other’s selection of Independent Counsel and/or for the appointment as Independent Counsel of a person
selected by such court or by such other person as such court shall designate, and the person with respect to whom all objections are so 

  
 9 

 
resolved or the person so appointed shall act as Independent Counsel under Section 12(a) hereof. Upon the due commencement of any judicial proceeding or arbitration pursuant to
Section 14(a) of this Agreement, Independent Counsel shall be discharged and relieved of any further responsibility in such capacity (subject to the applicable standards of professional conduct then prevailing). 

Section 13. Presumptions and Effect of Certain Proceedings. 

(a) In making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity making such
determination shall, to the fullest extent not prohibited by law, presume that Indemnitee is entitled to indemnification under this Agreement if Indemnitee has submitted a request for indemnification in accordance with Section 11(a) of this
Agreement, and the Company shall, to the fullest extent not prohibited by law, have the burden of proof to overcome that presumption in connection with the making by any person, persons or entity of any determination contrary to that presumption.
Neither the failure of the Company (including by its directors or Independent Counsel) to have made a determination prior to the commencement of any action pursuant to this Agreement that indemnification is proper in the circumstances because
Indemnitee has met the applicable standard of conduct, nor an actual determination by the Company (including by its directors or Independent Counsel) that Indemnitee has not met such applicable standard of conduct, shall be a defense to the action
or create a presumption that Indemnitee has not met the applicable standard of conduct. 
 (b) Subject to Section 14(e), if
the person, persons or entity empowered or selected under Section 12 of this Agreement to determine whether Indemnitee is entitled to indemnification shall not have made a determination within sixty (60) days after receipt by the Company
of the request therefor, the requisite determination of entitlement to indemnification shall, to the fullest extent not prohibited by law, be deemed to have been made and Indemnitee shall be entitled to such indemnification, absent (i) a
misstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such
indemnification under applicable law; provided, however, that such 60-day period may be extended for a reasonable time, not to exceed an additional thirty (30) days, if the person, persons or entity making the determination with respect to
entitlement to indemnification in good faith requires such additional time for the obtaining or evaluating of documentation and/or information relating thereto; and provided, further, that the foregoing provisions of this Section 13(b) shall
not apply (i) if the determination of entitlement to indemnification is to be made by the stockholders pursuant to Section 12(a) of this Agreement and if (A) within fifteen (15) days after receipt by the Company of the request
for such determination the Board has resolved to submit such determination to the stockholders for their consideration at an annual meeting thereof to be held within seventy-five (75) days after such receipt and such determination is made
thereat, or (B) a special meeting of stockholders is called within fifteen (15) days after such receipt for the purpose of making such determination, such meeting is held for such purpose within sixty (60) days after having been so
called and such determination is made thereat, or (ii) if the determination of entitlement to indemnification is to be made by Independent Counsel pursuant to Section 12(a) of this Agreement. 

  
 10 

 (c) The termination of any Proceeding or of any claim, issue or matter therein, by judgment,
order, settlement or conviction, or upon a plea of nolo contendere or its equivalent, shall not (except as otherwise expressly provided in this Agreement) of itself adversely affect the right of Indemnitee to indemnification or create
a presumption that Indemnitee did not act in good faith and in a manner which he reasonably believed to be in or not opposed to the best interests of the Company or, with respect to any criminal Proceeding, that Indemnitee had reasonable cause to
believe that his conduct was unlawful. 
 (d) For purposes of any determination of good faith, Indemnitee shall be deemed to
have acted in good faith if Indemnitee’s action is based on the records or books of account of the Enterprise, including financial statements, or on information supplied to Indemnitee by the directors or officers of the Enterprise in the course
of their duties, or on the advice of legal counsel for the Enterprise or on information or records given or reports made to the Enterprise by an independent certified public accountant or by an appraiser or other expert selected with the reasonable
care by the Enterprise. The provisions of this Section 13(d) shall not be deemed to be exclusive or to limit in any way the other circumstances in which the Indemnitee may be deemed to have met the applicable standard of conduct set forth in
this Agreement. 
 (e) The knowledge and/or actions, or failure to act, of any director, officer, trustee, partner, managing
member, fiduciary, agent or employee of the Enterprise shall not be imputed to Indemnitee for purposes of determining the right to indemnification under this Agreement. 
 Section 14. Remedies of Indemnitee. 
 (a) Subject to
Section 14(e), in the event that (i) a determination is made pursuant to Section 12 of this Agreement that Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made
pursuant to Section 10 of this Agreement, (iii) no determination of entitlement to indemnification shall have been made pursuant to Section 12(a) of this Agreement within ninety (90) days after receipt by the Company of the
request for indemnification, (iv) payment of indemnification is not made pursuant to Section 5, 6 or 7 or the last sentence of Section 12(a) of this Agreement within ten (10) days after receipt by the Company of a written request
therefor, (v) payment of indemnification pursuant to Section 3, 4 or 8 of this Agreement is not made within ten (10) days after a determination has been made that Indemnitee is entitled to indemnification, or (vi) in the event
that the Company or any other person takes or threatens to take any action to declare this Agreement void or unenforceable, or institutes any litigation or other action or Proceeding designed to deny, or to recover from, the Indemnitee the benefits
provided or intended to be provided to the Indemnitee hereunder, Indemnitee shall be entitled to an adjudication by a court of his entitlement to such indemnification or advancement of Expenses. Alternatively, Indemnitee, at his option, may seek an
award in arbitration to be conducted by a single arbitrator pursuant to the Commercial Arbitration Rules of the American Arbitration Association. Indemnitee shall commence such proceeding seeking an adjudication or an award in arbitration within 180
days following the date on which Indemnitee first has the right to commence such proceeding pursuant to this Section 14(a); provided, however, that the foregoing clause shall not apply in respect of a proceeding brought by
Indemnitee to enforce his rights under Section 5 of this Agreement. The Company shall not oppose Indemnitee’s right to seek any such adjudication or award in arbitration. 

  
 11 

 (b) In the event that a determination shall have been made pursuant to Section 12(a) of
this Agreement that Indemnitee is not entitled to indemnification, any judicial proceeding or arbitration commenced pursuant to this Section 14 shall be conducted in all respects as a de novo trial, or arbitration, on the merits
and Indemnitee shall not be prejudiced by reason of that adverse determination. In any judicial proceeding or arbitration commenced pursuant to this Section 14 the Company shall have the burden of proving Indemnitee is not entitled to
indemnification or advancement of Expenses, as the case may be. 
 (c) If a determination shall have been made pursuant to
Section 12(a) of this Agreement that Indemnitee is entitled to indemnification, the Company shall be bound by such determination in any judicial proceeding or arbitration commenced pursuant to this Section 14, absent (i) a
misstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such
indemnification under applicable law. 
 (d) The Company shall, to the fullest extent not prohibited by law, be precluded from
asserting in any judicial proceeding or arbitration commenced pursuant to this Section 14 that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court or before any such
arbitrator that the Company is bound by all the provisions of this Agreement. It is the intent of the Company that, to the fullest extent permitted by law, the Indemnitee not be required to incur legal fees or other Expenses associated with the
interpretation, enforcement or defense of Indemnitee’s rights under this Agreement by litigation or otherwise because the cost and expense thereof would substantially detract from the benefits intended to be extended to the Indemnitee
hereunder. The Company shall, to the fullest extent permitted by law, indemnify Indemnitee against any and all Expenses and, if requested by Indemnitee, shall (within ten (10) days after receipt by the Company of a written request therefor)
advance, to the extent not prohibited by law, such Expenses to Indemnitee, which are incurred by Indemnitee in connection with any action brought by Indemnitee for indemnification or advance of Expenses from the Company under this Agreement or under
any directors’ and officers’ liability insurance policies maintained by the Company if, in the case of indemnification, Indemnitee is wholly successful on the underlying claims; if Indemnitee is not wholly successful on the underlying
claims, then such indemnification shall be only to the extent Indemnitee is successful on such underlying claims or otherwise as permitted by law, whichever is greater. 
 (e) Notwithstanding anything in this Agreement to the contrary, no determination as to entitlement of Indemnitee to indemnification under this Agreement shall be required to be made prior to the final
disposition of the Proceeding. 
 Section 15. Non-exclusivity; Survival of Rights; Insurance; Subrogation.

 (a) The rights of indemnification and to receive advancement of Expenses as provided by this Agreement shall not be deemed
exclusive of any other rights to which Indemnitee may at any time be entitled under applicable law, the Certificate of Incorporation, the 

  
 12 

 
By-laws, any agreement, a vote of stockholders or a resolution of directors, or otherwise. No amendment, alteration or repeal of this Agreement or of any provision hereof shall limit or restrict
any right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his Corporate Status prior to such amendment, alteration or repeal. To the extent that a change in Delaware law, whether by statute or
judicial decision, permits greater indemnification or advancement of Expenses than would be afforded currently under the Certificate of Incorporation and this Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by this
Agreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right and remedy shall be cumulative and in addition to every other right and
remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other right or remedy.

 (b) To the extent that the Company maintains an insurance policy or policies providing liability insurance for directors,
officers, employees, or agents of the Enterprise, Indemnitee shall be covered by such policy or policies in accordance with its or their terms to the maximum extent of the coverage available for any such director, officer, employee or agent under
such policy or policies. If, at the time of the receipt of a notice of a claim pursuant to the terms hereof, the Company has director and officer liability insurance in effect, the Company shall give prompt notice of such claim or of the
commencement of a Proceeding, as the case may be, to the insurers in accordance with the procedures set forth in the respective policies. The Company shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of
the Indemnitee, all amounts payable as a result of such Proceeding in accordance with the terms of such policies. 
 (c) In the
event of any payment under this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all papers required and take all action necessary to secure such rights,
including execution of such documents as are necessary to enable the Company to bring suit to enforce such rights. 
 (d) The
Company shall not be liable under this Agreement to make any payment of amounts otherwise indemnifiable (or for which advancement is provided hereunder) hereunder if and to the extent that Indemnitee has otherwise actually received such payment
under any insurance policy, contract, agreement or otherwise. 
 (e) The Company[’s obligation to indemnify or advance
Expenses hereunder to Indemnitee who is or was serving at the request of the Company as an officer or director shall be reduced by any amount Indemnitee has actually received as indemnification or advancement of Expenses from such other corporation,
limited liability company, partnership, joint venture, trust or other enterprise.]3 [hereby acknowledges that Indemnitee has certain rights to indemnification, advancement of expenses and/or insurance provided by the Fund and certain of its affiliates (collectively, the “Fund
Indemnitors”). The Company hereby agrees (i) that it is the indemnitor of first resort (i.e., its obligations to Indemnitee are primary and any obligation of the 

 

	3 	Insert for officers or directors that are not affiliated with Funds that Indemnify them. 

  
 13 

 
Fund Indemnitors to advance expenses or to provide indemnification for the same expenses or liabilities incurred by Indemnitee are secondary), (ii) that it shall be required to advance the
full amount of Expenses incurred by Indemnitee and shall be liable for the full amount of all Expenses, judgments, penalties, fines and amounts paid in settlement to the extent legally permitted and as required by the Certificate of Incorporation
(or any agreement between the Company and Indemnitee), without regard to any rights Indemnitee may have against the Fund Indemnitors, and, (iii) that it irrevocably waives, relinquishes and releases the Fund Indemnitors from any and all claims
against the Fund Indemnitors for contribution, subrogation or any other recovery of any kind in respect thereof. The Company further agrees that no advancement or payment by the Fund Indemnitors on behalf of Indemnitee with respect to any claim for
which Indemnitee has sought indemnification from the Company shall affect the foregoing and the Fund Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of
Indemnitee against the Company. The Company and Indemnitee agree that the Fund Indemnitors are express third party beneficiaries of the terms hereof.]4 
 Section 16. Duration of Agreement. This Agreement shall continue until and terminate upon the later of: (a) ten (10) years after the date that Indemnitee shall have ceased to serve
as a [director] [officer] of the Company or (b) one (1) year after the final termination of any Proceeding then pending in respect of which Indemnitee is granted rights of indemnification or advancement of Expenses hereunder and of any
proceeding commenced by Indemnitee pursuant to Section 14 of this Agreement relating thereto. The indemnification and advancement of expenses rights provided by or granted pursuant to this Agreement shall be binding upon and be enforceable by
the parties hereto and their respective successors and assigns (including any direct or indirect successor by purchase, merger, consolidation or otherwise to all or substantially all of the business or assets of the Company), shall continue as to an
Indemnitee who has ceased to be a director, officer, employee or agent of the Company or of any other Enterprise, and shall inure to the benefit of Indemnitee and his or her spouse, assigns, heirs, devisees, executors and administrators and other
legal representatives. 
 Section 17. Severability. If any provision or provisions of this Agreement shall be held
to be invalid, illegal or unenforceable for any reason whatsoever: (a) the validity, legality and enforceability of the remaining provisions of this Agreement (including without limitation, each portion of any Section of this Agreement
containing any such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall not in any way be affected or impaired thereby and shall remain enforceable to the fullest extent permitted by
law; (b) such provision or provisions shall be deemed reformed to the extent necessary to conform to applicable law and to give the maximum effect to the intent of the parties hereto; and (c) to the fullest extent possible, the provisions
of this Agreement (including, without limitation, each portion of any Section of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall be construed so
as to give effect to the intent manifested thereby. 
  

	4 	Included if the Indemnitee is affiliated with a fund or other entity that provides indemnification to the Indemnitee. 

  
 14 

 Section 18. Enforcement. 

(a) The Company expressly confirms and agrees that it has entered into this Agreement and assumed the obligations imposed on it hereby in
order to induce Indemnitee to serve as a director or officer of the Company, and the Company acknowledges that Indemnitee is relying upon this Agreement in serving as a director or officer of the Company. 

(b) This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes
all prior agreements and understandings, oral, written and implied, between the parties hereto with respect to the subject matter hereof; provided, however, that this Agreement is a supplement to and in furtherance of the Certificate of
Incorporation and applicable law, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder. 
 Section 19. Modification and Waiver. No supplement, modification or amendment of this Agreement shall be binding unless executed in writing by the parties hereto. No waiver of any of the
provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions of this Agreement nor shall any waiver constitute a continuing waiver. 
 Section 20. Notice by Indemnitee. Indemnitee agrees promptly to notify the Company in writing upon being served with any summons, citation, subpoena, complaint, indictment, information or
other document relating to any Proceeding or matter which may be subject to indemnification or advancement of Expenses covered hereunder. The failure of Indemnitee to so notify the Company shall not relieve the Company of any obligation which it may
have to the Indemnitee under this Agreement or otherwise. 
 Section 21. Notices. All notices, requests,
demands and other communications under this Agreement shall be in writing and shall be deemed to have been duly given if (a) delivered by hand and receipted for by the party to whom said notice or other communication shall have been directed,
(b) mailed by certified or registered mail with postage prepaid, on the third business day after the date on which it is so mailed, (c) mailed by reputable overnight courier and receipted for by the party to whom said notice or other
communication shall have been directed or (d) sent by facsimile transmission, with receipt of oral confirmation that such transmission has been received: 
 (a) If to Indemnitee, at the address indicated on the signature page of this Agreement, or such other address as Indemnitee shall provide to the Company. 

(b) If to the Company to 
 Enanta Pharmaceuticals, Inc. 
 Attn: Jay R. Luly, Ph.D. 

Chief Executive Officer 
 500 Arsenal Street 
 Watertown, MA 02472 

or to any other address as may have been furnished to Indemnitee by the Company. 

Section 22. Contribution. To the fullest extent permissible under applicable law, if the indemnification provided for in this
Agreement is unavailable to Indemnitee for any reason 

  
 15 

 
whatsoever, the Company, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by Indemnitee, whether for judgments, fines, penalties, excise taxes, amounts paid or to be
paid in settlement and/or for Expenses, in connection with any claim relating to an indemnifiable event under this Agreement, in such proportion as is deemed fair and reasonable in light of all of the circumstances of such Proceeding in order to
reflect (i) the relative benefits received by the Company and Indemnitee as a result of the event(s) and/or transaction(s) giving cause to such Proceeding; and/or (ii) the relative fault of the Company (and its directors, officers,
employees and agents) and Indemnitee in connection with such event(s) and/or transaction(s). 
 Section 23. Applicable
Law and Consent to Jurisdiction. This Agreement and the legal relations among the parties shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware, without regard to its conflict of laws rules.
Except with respect to any arbitration commenced by Indemnitee pursuant to Section 14(a) of this Agreement, the Company and Indemnitee hereby irrevocably and unconditionally (i) agree that any action or proceeding arising out of or in
connection with this Agreement shall be brought only in Delaware Court, and not in any other state or federal court in the United States of America or any court in any other country, (ii) consent to submit to the exclusive jurisdiction of the
Delaware Court for purposes of any action or proceeding arising out of or in connection with this Agreement, (iii) appoint, to the extent such party is not otherwise subject to service of process in the State of Delaware, irrevocably
Corporation Service Company, 2711 Centerville Road, Suite 400, Wilmington, New Castle County, Delaware 19801 as its agent in the State of Delaware as such party’s agent for acceptance of legal process in connection with any such action or
proceeding against such party with the same legal force and validity as if served upon such party personally within the State of Delaware, (iv) waive any objection to the laying of venue of any such action or proceeding in the Delaware Court,
and (v) waive, and agree not to plead or to make, any claim that any such action or proceeding brought in the Delaware Court has been brought in an improper or inconvenient forum. 

Section 24. Identical Counterparts. This Agreement may be executed in one or more counterparts, each of which shall for all
purposes be deemed to be an original but all of which together shall constitute one and the same Agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of this
Agreement. 
 Section 25. Miscellaneous. Use of the masculine pronoun shall be deemed to include usage of the
feminine pronoun where appropriate. The headings of this Agreement are inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction thereof. 

  
 16 

 IN WITNESS WHEREOF, the parties have caused this Agreement to be signed as of the day and
year first above written. 
  

									
	ENANTA PHARMACEUTICALS, INC.	 		 	INDEMNITEE
				
	By:	 	  
	 		 	  

	 Name:
	 	Jay R. Luly, Ph.D.	 		 		 	
	Office:	 	President and Chief Executive Officer	 		 	Address:	 	  

		 		 		 	  

		 		 		 	  

  
 17

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