Document:

AMENDED AND RESTATED STOCK INCENTIVE PLAN

 Exhibit 10.2 
  
 TRIMERIS, INC. 
 AMENDED AND RESTATED STOCK INCENTIVE PLAN 
  
 (formerly, the Trimeris, Inc. New Stock Option Plan) 
  
 1.
Purpose 
  
 The Trimeris, Inc. Amended and Restated Stock
Incentive Plan (formerly, the Trimeris, Inc. New Stock Option Plan) (the “Plan”) is established to advance the interests of the Company’s stockholders by creating an incentive for, and enhancing the Company’s ability to attract,
retain and motivate, key employees, directors and consultants or advisors of Trimeris, Inc. and any successor corporations thereto (collectively, the “Company”) or future parent and/or subsidiary corporations of such corporation (as
defined in Sections 424(e) and 424(f) of the Internal Revenue Code of 1986, as amended, and any regulations promulgated thereunder (the “Code”)) (all of whom, along with the Company, sometimes being individually referred to as a
“Participating Company” and collectively referred to as the “Participating Company Group”) by providing such persons with equity ownership opportunities and performance-based incentives and thereby better aligning the interests
of such persons with those of the Company’s stockholders. 
  
 2.
Eligibility 
  
 All of the Company’s employees,
officers, directors, consultants and advisors are eligible to be granted options, restricted stock or other stock-based awards (each, an “Award”) under the Plan. Any person who has been granted an Award under the Plan shall be deemed a
“Participant.” The Board of Directors of the Company (the “Board”), in its sole discretion, shall determine which persons shall be granted Awards under the Plan. A director of the Company shall be eligible to be granted an
Incentive Stock Option (as hereinafter defined) only if the director is also an employee of the Company. A consultant or advisor to the Company or a non-employee director of the Company shall be eligible to be granted only Awards other than
Incentive Stock Options. Participants may, if otherwise eligible, be granted additional Awards. Subject to the provisions of Section 4(b) relating to adjustments upon changes in stock, no person shall be eligible to be granted options or restricted
stock covering more than five hundred thousand (500,000) shares of the Company’s common stock in any calendar year. 
  
 3. Administration; Delegation 
  
 Administration by Board. The Plan shall be administered by the Board. The Board shall have authority to grant Awards and to adopt, amend and repeal such
administrative rules, guidelines and practices relating to the Plan as it shall deem advisable from time to time. The Board may correct any defect, supply any omission or reconcile any inconsistency in the Plan or any Award in the manner and to the
extent it shall deem expedient to carry the Plan into effect and it shall be the sole and final judge of such expediency. No member of the Board shall be liable for any action or determination relating to the Plan. All decisions by the Board shall
be made in the Board’s sole discretion and shall be final and binding on all persons having or claiming any interest in the Plan or in any Award. No director or person acting pursuant to the authority delegated by the Board shall be liable for
any action or determination under the Plan made in good faith. 
  
 (b) Delegation to Executive Officers. To the extent permitted by applicable law, the Board may delegate to one or more executive officers of the Company the power to make Awards and exercise such other powers under the Plan as the
Board may determine, provided that the Board shall fix the maximum number of shares subject to Awards and the maximum number of shares for any one Participant to be made by such executive officers. 
  
 (c) Appointment of Committees. To the extent permitted by applicable
law, the Board may delegate any or all of its powers under the Plan to one or more committees or subcommittees of the Board (each, a “Committee”). For so long as the common stock, $.001 par value per share (the “Common 

 Stock”), of the Company is registered under the Securities Exchange Act of 1934 (the “Exchange Act”), the
Board shall appoint one such Committee of not less than two members, each member of which shall be a “non-employee director” as defined in Rule 16b-3 promulgated under the Exchange Act. All references in the Plan to the “Board”
shall mean a Committee or the Board or the executive officer referred to in Section 3(b) to the extent that the Board’s powers or authority under the Plan have been delegated to such Committee or executive officer. 
  
 4. Stock Available For Awards 
  
 (a) Number of Shares. Subject to adjustment under Section 4(b),
Awards may be made under the Plan for up to a maximum of Five Million Four Hundred Two Thousand Nine Hundred Forty-One (5,402,941) shares of Common Stock, any or all of which can be used for Incentive Stock Options. If any Award expires or is
terminated, surrendered or canceled without having been fully exercised or is forfeited in whole or in part or results in any Common Stock not being issued, the unused Common Stock covered by such Award shall again be available for the grant of
Awards under the Plan, subject, however, in the case of Incentive Stock Options, to any limitation required under the Code. Shares issued under the Plan may consist in whole or in part of authorized but unissued shares or treasury shares.

  
 (b) Adjustments to Common Stock. In the event of any
stock split, stock dividend, recapitalization, reorganization, merger, consolidation, combination, exchange of shares, liquidation, spin-off or other similar change in capitalization or event, or any distribution to holders of Common Stock other
than a normal cash dividend, (i) the number and class of securities available under this Plan, (ii) the number and class of security and exercise price per share subject to each outstanding Option (as defined below), (iii) the repurchase price per
security subject to each outstanding Restricted Stock Award (as defined below), and (iv) the terms of each other outstanding stock-based Award, if any, shall be appropriately adjusted by the Company (or substituted Awards may be made, if applicable)
to the extent the Board shall determine, in good faith, that such an adjustment (or substitution) is necessary and appropriate. If this Section 4(b) applies and Section 9(a) also applies to any event, Section 9(a) shall be applicable to such event,
and this Section 4(b) shall not be applicable. 
  
 5. Stock Options

  
 (a) General. The Board may grant options to purchase
Common Stock (each, an “Option”) and determine the number of shares of Common Stock to be covered by each Option, the exercise price of each Option and the conditions and limitations applicable to the exercise of each Option, including
conditions relating to applicable federal or state securities laws, as it considers necessary or advisable. Any Option granted to a Participant who is subject to the provisions of Section 16 of the Exchange Act shall not become exercisable for a
period of at least six (6) months following the date of grant. An Option which is not intended to be an Incentive Stock Option shall be designated a “Nonstatutory Stock Option.” The granting of discounted Nonstatutory Stock Options is
expressly prohibited under this Plan. 
  
 (b) Incentive Stock
Options. An Option that the Board intends to be an “incentive stock option” as defined in Section 422 of the Code (an “Incentive Stock Option”) shall only be granted to employees of the Company and shall be subject to and
construed consistently with the requirements of Section 422 of the Code. The Company shall have no liability to a Participant who has been awarded an Option (an “Optionee”), or any other party, if an Option (or any part thereof) which is
intended to be an Incentive Stock Option is not an Incentive Stock Option. 
  
 (c) Exercise Price. The Board shall establish, in its sole discretion, the exercise price at the time each Option is granted and specify it in the applicable option agreement; provided, however, that (i) the
exercise price per share for an Incentive Stock Option shall be not less than the fair market value of a share of Common Stock on the date of grant of such Incentive Stock Option, as determined by the Board in good faith (the “Fair Market
Value”), and (ii) the exercise price per share of an Incentive Stock Option granted to an Optionee who at the time the Incentive Stock Option is granted owns stock possessing more than ten percent (10%) of the total combined voting power of all
classes of stock of a Participating Company within the meaning of Section 422(b)(6) of the Code (a “Ten Percent Owner Optionee”) shall 

 be not less than one hundred ten percent (110%) of the Fair Market Value. Nothing hereinabove shall require that any such
assumption or modification result in the Option having the same characteristics, attributes or tax treatment as the Option for which it is substituted. 
  
 (d) $100,000 Limitation. The aggregate fair market value, determined as of the date on which an Incentive Stock Option is granted, of the shares of
Common Stock with respect to which Incentive Stock Options (determined without regard to this subsection) are first exercisable during any calendar year (under this Plan or under any other plan of the Participating Company Group) by any Optionee
shall not exceed $100,000. If such limitation would be exceeded with respect to an Optionee for a calendar year, the Incentive Stock Option shall be deemed a Nonstatutory Stock Option to the extent of such excess. 
  
 (e) Time for Granting Incentive Stock Options. All Incentive Stock
Options must be granted, if at all, within ten (10) years from the earlier of the date the Plan is adopted by the Board or the date the Plan is duly approved by the stockholders of the Company. 
  
 (f) Duration of Options. Each Option shall be exercisable at such
times and subject to such terms and conditions as the Board may specify in the applicable option agreement; provided, however, that (i) no Incentive Stock Option shall be exercisable after the expiration of ten (10) years after the date such
Incentive Stock Option is granted, (ii) no Incentive Stock Option granted to a Ten Percent Owner Optionee shall be exercisable after the expiration of five (5) years after the date such Incentive Stock Option is granted and (iii) no Incentive Stock
Option shall be exercisable after the date the Optionee’s employment with the Participating Company Group is terminated for cause (as determined in the sole discretion of the Board); and provided, further, that an Option shall terminate and
cease to be exercisable no later than three (3) months after the date on which the Optionee terminates employment with the Participating Company Group, unless Optionee’s employment with the Participating Company Group shall have terminated as a
result of the Optionee’s death, disability (within the meaning of Section 22(e)(3) of the Code) or Retirement (as defined herein). In the event the Optionee’s employment with the Participating Company Group shall have terminated due to
Optionee’s disability (within the meaning of Section 22(e)(3) of the Code), the Option shall immediately cease to vest and unvested portions shall expire immediately, while vested portions shall remain exercisable until the Option terminates,
but no later than twelve (12) months from the date on which the Optionee’s employment terminated. In the event the Optionee’s employment with the Participating Company Group shall have terminated due to Optionee’s death, the Option
shall become immediately vested and exercisable and remain exercisable until the Option shall terminate no later than twelve (12) months from the date on which the Optionee’s employment terminated. In the event the Optionee’s employment
with the Participating Company Group shall have terminated due to Optionee’s Retirement, the Option (if granted on or after November 28, 2001) shall immediately cease to vest and unvested portions shall expire immediately, while vested portions
shall remain exercisable until the expiration of ten (10) years after the date such Option is granted, except as provided in Section 9. 
  
 For the purposes of this Plan, “Retirement” shall be defined as departing employment and the Participating Company Group’s Board of Directors after
attaining the minimum age of 60 years and completing (i) a minimum of ten (10) years of full-time service as an employee of the Participating Company Group or (ii) a minimum of ten (10) years of full-time service, of which (I) at least five (5)
years of full time service were as an employee of the Participating Company Group and (II) the remaining years were either from full time service as such an employee or years of service (other than while employed by the Participating Company Group)
on the Participating Company Group’s Board of Directors. 
  
 (g) Exercise of Options. Options may be exercised only by delivery to the Company of a written notice of exercise signed by the proper person together with payment in full as specified in Sections 5(c) and 5(f) for the number of
shares for which the Option is exercised. 
  
 (h) Payment Upon
Exercise. Common Stock purchased upon the exercise of an Option granted under the Plan shall be paid for as follows: 
  
 (1) in cash or by check, payable to the order of the Company; 

 (2) except as the Board may otherwise provide in an option agreement, by delivery of an irrevocable and
unconditional undertaking by a creditworthy broker to deliver promptly to the Company sufficient funds to pay the exercise price, or delivery by the Optionee to the Company of a copy of irrevocable and unconditional instructions to a creditworthy
broker to deliver promptly to the Company cash or a check sufficient to pay the exercise price; 
  
 (3) to the extent permitted by the Board and expressly provided in an option agreement, (i) by delivery of shares of Common Stock owned by the Optionee
valued at their Fair Market Value, which Common Stock was owned by the Optionee at least six (6) months prior to such delivery, (ii) to the extent permitted by applicable law, by delivery of a promissory note of the Optionee to the Company secured
by valuable collateral acceptable to the Board and on other terms determined by the Board, or (iii) by payment of such other lawful consideration as the Board may determine; or 
  
 (4) any combination of the above permitted forms of payment. 
  
 6. Restricted Stock 
  
 (a) Grants. The Board may grant Awards entitling recipients to acquire shares of Common Stock, subject to the right of the Company to repurchase
all or part of such shares at their issue price or other stated or formula price (or to require forfeiture of such shares if issued at no cost) from the recipient in the event that conditions specified by the Board in the applicable Award are not
satisfied prior to the end of the applicable restriction period or periods established by the Board for such Award, and subject to such other terms and conditions as the Board shall determine (each, a “Restricted Stock Award”). 

 
 (b) Terms and Conditions. The Board shall determine the terms and
conditions of any such Restricted Stock Award, including the duration of restrictions, conditions for repurchase (or forfeiture) and the issue price, if any; provided, however, that any Restricted Stock Award granted to a Participant who is subject
to the provisions of Section 16 of the Exchange Act shall restrict the release of shares under the Restricted Stock Award for a period of at least six (6) months from the date of grant. Any stock certificates issued in respect of a Restricted Stock
Award shall be registered in the name of the Participant and held in escrow by the Company, together with a stock power endorsed in blank, with the Company (or its designee). At the expiration of the applicable restriction periods, the Company (or
such designee) shall deliver the certificates no longer subject to such restrictions to the Participant or if the Participant has died, to the beneficiary designated, in a manner determined by the Board, by a Participant to receive amounts due or
exercise rights of the Participant in the event of the Participant’s death (the “Designated Beneficiary”). In the absence of an effective designation by a Participant, Designated Beneficiary shall mean the Participant’s estate.

  
 7. Other Stock-based Awards 
  
 The Board shall have the right to grant other Awards based upon the Common
Stock having such terms and conditions as the Board may determine, including the grant of shares based upon certain conditions, the grant of securities convertible into Common Stock and the grant of stock appreciation rights. 
  
 8. General Provisions Applicable to Awards 
  
 (a) Transferability of Awards. Except as the Board may otherwise
determine or provide in an Award, Awards shall not be sold, assigned, transferred, pledged or otherwise encumbered by the person to whom they are granted, either voluntarily or by operation of law, except by will or the laws of descent and
distribution, and, during the life of the Participant, to the extent relevant in the context, shall include references to authorized transferees. 

 (b) Documentation. Each Award under the Plan shall be evidenced by a written instrument in such
form as the Board shall determine. Each Award may contain terms and conditions in addition to those set forth in the Plan. 
  
 (c) Board Discretion. Except as otherwise provided by the Plan, each type of Award may be made alone or in addition or in relation to any other
type of Award. The terms of each type of Award need not be identical, and the Board need not treat Participants uniformly. 
  
 (d) Termination of Status. The Board shall determine the effect on an Award of the disability, death, retirement, authorized leave of absence or
other change in the employment or other status of a Participant and the extent to which, and the period during which, the Participant, the Participant’s legal representative, conservator, guardian or Designated Beneficiary may exercise rights
under the Award. 
  
 (e) Withholding. Each Participant
shall pay to the Company, or make provision satisfactory to the Board for payment of, any taxes required by law to be withheld in connection with Awards to such Participant no later than the date of the event creating the tax liability. The Board
may allow Participants to satisfy such tax obligations in whole or in part in shares of Common Stock, including shares retained from the Award creating the tax obligation, valued at their Fair Market Value. The Company may, to the extent permitted
by law, deduct any such tax obligations from any payment of any kind otherwise due to a Participant. 
  
 (f) Amendment of Award. The Board may amend, modify or terminate any outstanding Award, including but not limited to, substituting therefor another
Award of the same of a different type, changing the date or exercise or realization, and converting an Incentive Stock Option to a Nonstatutory Stock Option, provided that the Participant’s consent to such action shall be required unless the
Board determines that the action, taking into account any related action, would not materially and adversely affect the Participant. Notwithstanding anything herein to the contrary, the Board of Directors may not change the exercise price of any
Incentive Stock Option or Nonstatutory Stock Option previously granted except pursuant to Section 9 and Section 4(b) of the Plan and Section 424(a) of the Code. 
  

(g) Conditions on Delivery of Stock. The Company shall not be obligated to deliver any shares of Common Stock pursuant to the Plan or to remove
restrictions from shares previously delivered under the Plan until (i) all conditions of the Award have been met or removed to the satisfaction of the Company, (ii) in the opinion of the Company’s counsel, all other legal matters in connection
with the issuance and delivery of such shares have been satisfied, including any applicable securities laws and any applicable stock exchange or stock market rules and regulations, and (iii) the Participant has executed and delivered to the Company
such representations or agreements as the Company may consider appropriate to satisfy the requirements of any applicable laws, rules or regulations. 
  
 9. Acquisition Events 
  
 (a) Consequences of Acquisition Events. Except to the extent otherwise provided in the instrument evidencing the Award or in any other agreement
between the Participant and the Company: 
  
 (i) Upon the
occurrence of an Acquisition Event (as hereinafter defined), 
  
 (A) all Restricted Stock Awards then outstanding shall become fully vested and immediately free of all restrictions; and 
  
 (B) all other stock-based Awards other than Options and stock appreciation rights shall become immediately exercisable, realizable or vested in full, or
shall be immediately free of all restrictions or conditions, as the case may be. 
  
 (ii) Upon the execution by the Company of an agreement to effect an Acquisition Event other than a Change of Control Event (as hereinafter defined), all Options and stock 

 appreciation rights then outstanding shall become fully vested and immediately exercisable in full upon the occurrence of
the Acquisition Event or such earlier date as may be specified by the Board by written notice to the Participants, and the Board may take one or both of the following additional actions with respect to then outstanding Options and stock appreciation
rights: (A) provide that such Options and stock appreciation rights shall be assumed, or equivalent Options or stock appreciation rights be substituted by the acquiring or succeeding corporation (or an affiliate thereof), or (B) upon written notice
to the Participants, provide that all then unexercised Options and stock appreciation rights will terminate to the extent not exercised by the Participants prior to the consummation of such Acquisition Event or such earlier date as may be specified
by the Board by written notice to Participants. 
  
 (iii) Upon
the occurrence of a Change of Control Event, all Options and stock appreciation rights then outstanding shall become fully vested and immediately exercisable in full. 
  
 As used herein, an “Acquisition Event” shall mean: (a) any merger or consolidation which results in the voting
securities of the Company outstanding immediately prior thereto representing (either by remaining outstanding or by being converted into voting securities of the surviving or acquiring entity) less than 60% of the combined voting power of the voting
securities of the Company or such surviving or acquiring entity outstanding immediately after such merger or consolidation; (b) any sale of all or substantially all of the assets of the Company; (c) the complete liquidation of the Company; or (d)
the acquisition of “beneficial ownership” (as defined in Rule 13d-3 under the Exchange Act) of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding securities (other than
through a merger or consolidation or an acquisition of securities directly from the Company) by any “person,” as such term is used in Section 13(d) and 14(d) of the Exchange Act, other than the Company, any trustee or other fiduciary
holding securities under an employee benefit plan of the Company or any corporation owned directly or indirectly by the stockholders of the Company (an event specified in this clause (d) being referred to as a “Change of Control Event”).

  
 (b) Assumption of Options Upon Certain Events. The
Board may grant Awards under the Plan in substitution for stock and stock-based awards held by employees of another corporation who become employees of the Company as a result of a merger or consolidation of the employing corporation with the
Company or the acquisition by the Company of property or stock of the employing corporation. The substitute Awards shall be granted on such terms and conditions as the Board considers appropriate in the circumstances. 
  
 10. Miscellaneous 
  
 (a) No Right to Employment or Other Status. No person shall have any claim or right to be granted an Award, and the
grant of an Award shall not be construed as giving a Participant the right to continued employment or any other relationship with the Company. The Company expressly reserves the right at any time to dismiss or otherwise terminate its relationship
with a Participant free from any liability or claim under the Plan, except as expressly provided in the applicable Award. 
  
 (b) No Rights as Stockholder. Subject to the provisions of the applicable Award, no Participant or Designated Beneficiary shall have any right as a
stockholder with respect to any shares of Common Stock to be distributed with respect to an Award until becoming the record holder of such shares. 
  
 (c) Status of Rights to Payments under Plan. To the extent that any person acquires a right to receive payments from the Company under the Plan,
such right shall, except as otherwise provided by the Board, be no greater than the right of an unsecured general creditor of the Company. All payments to be made hereunder shall be paid from the general funds of the Company, and no special or
separate fund shall be established and no segregation of assets shall be made to assure payment of such amounts, except as otherwise provided by the Committee. 
 With respect to any payments not yet made to a Participant by the Company, nothing contained herein shall give any such Optionee any rights that are greater than those of a general creditor of the Company. 
  

 6 

 (d) Subject to Law. The Plan and the grant of Awards hereunder shall be subject to all applicable
federal and state laws, rules, and regulations and to such approvals by any United States government or regulatory agency as may be required. 
  
 (e) Severability. If any provision of this Plan or an option agreement is or becomes or is deemed invalid, illegal or unenforceable in any
jurisdiction, or would disqualify the Plan or any agreement evidencing an Award under any law deemed applicable by the Board, such provision shall be construed or deemed amended to conform to applicable laws or, if it cannot be construed or deemed
amended without, in the determination of the Board, materially altering the intent of the Plan or the agreement, it shall be stricken and the remainder of the Plan or the agreement shall remain in full force and effect. 
  
 (f) Effective Date and Term of Plan. The Plan shall become effective
on the date on which it is adopted by the Board, but no Incentive Stock Option granted to an Optionee shall be effective unless and until the Plan has been approved by the Company’s stockholders. No Awards shall be granted under the Plan after
the completion of ten years from the earlier of (i) the date on which the Plan was adopted by the Board or (ii) the date the Plan was approved by the Company’s stockholders, but Awards previously granted may extend beyond that date. 

 
 (g) Amendment of Plan. The Board may amend, suspend or terminate
the Plan or any portion thereof at any time, provided that no increase in the total number of shares available for Awards under the Plan (except by operation of the provisions of Section 4(b) above) or for grants of Incentive Stock Options under the
Plan may be made, unless and until such amendment shall have been approved by the Company’s stockholders. 
  
 (h) Stockholder Approval. For purposes of this Plan, stockholder approval shall mean approval by a vote of the stockholders in accordance with the
requirements of Section 422 of the Code. 
  
 (i) Governing
Law. The provisions of the Plan and all Awards made hereunder shall be governed by and interpreted in accordance with the laws of the State of Delaware, without regard to any applicable conflicts of law.EXECUTIVE AGREEMENT

 Exhibit 10.20 
  
 Robert R. Bonczek, our Chief Financial Officer and General Counsel, is a party to an employment agreement with Trimeris
dated January 7, 2000, a copy of which is attached to this Exhibit 10.20. Pursuant to the terms of the agreement, Mr. Bonczek’s base salary is reviewed annually and for fiscal year 2005, has been set at $303,000. 

 EXECUTIVE AGREEMENT 
  
 THIS AGREEMENT is made and entered into this the 7th day of January, 2000, by and between TRIMERIS, Inc., a Delaware
corporation (the “Company”), and ROBERT R. BONCZEK (“Bonczek”). 
  
 W I T N E S S E T H: 
  
 WHEREAS,
Bonczek and the Company deem it to be in their respective best interests to enter into an agreement providing for the Company’s appointment of Bonczek as an officer of the Company pursuant to the terms herein stated; 
  
 NOW, THEREFORE, in consideration of the premises and the mutual promises and
agreements contained herein, it is hereby agreed as follows: 
  
 1. Effective
Date. This Agreement shall be effective as of the 2nd day of September, 1999, which date shall be referred to herein as the “Effective Date”. 
  
 2. Position and Duties. 
  
 (a) The Company hereby appoints Bonczek as its Acting Chief Administrative Officer and Acting Chief Financial Officer commencing as of the Effective Date
for the “Term” (as herein defined below). In this capacity, Bonczek shall devote his best efforts and attention to the performance of the services customarily incident to such offices and positions and to such other services of a senior
executive nature as may be reasonably requested by the Chief Executive Officer (CEO) and Chief Scientific Officer (CSO) of the Company which may include services for one or more subsidiaries or affiliates of the Company. Bonczek shall in his
capacity as an officer of the Company be responsible to and obey the reasonable and lawful directives of the CEO and CSO. Bonczek shall use his best efforts during the Term to protect, encourage, and promote the interests of the Company. 

 
 (b) The Company and Bonczek agree that the position, salary and duties
outlined in subsection 2(a) above and subsections 3(a) and (b) below are transitional in nature. The Company, in its sole discretion, shall have the ability to reassign Bonczek to other duties or offices (including a reassignment to a lesser role),
to reduce Bonczek’s salary or to change Bonczek’s position or title at any time without Bonczek’s consent, provided that: 
  
 (i) In the case of a reassignment or change of position or title in which Bonczek remains an officer of the Company, such reassignment or change of
position or title leaves Bonczek in a position at least comparable to Bonczek’s status and compensation under the Initial Consulting Agreement between Bonczek and Company dated August 25, 1997 and as amended on January 23, 1998 and April 28,
1999 (the “Initial Consulting Agreement”); and 

 (ii) In the case of a reassignment or change of position or title in which Bonczek is no longer an
officer of the Company, such reassignment or change of position or title leaves Bonczek in a position at least comparable to Bonczek’s status and compensation under the Initial Consulting Agreement for a period of at least twenty-four (24) full
months following the reassignment or change (the “Protected Period”). 
  
 The Company and Bonczek agree that any such reassignment, reduction of salary or change in position or title permitted under this paragraph (a) (“Permitted Reassignment”) shall not entitle Bonczek to the
payment of severance benefits under the Severance Agreement (as herein defined below). 
  
 3. Compensation. 
  
 (a) Base Salary. The Company shall
pay to Bonczek during the Term a minimum salary at the rate of Two Hundred Ten Thousand dollars ($210,000.00) per year and agrees that such salary shall be reviewed at least annually. Such salary shall be subject to discretionary annual increases as
determined by the Compensation Committee of the Board of Directors. Such salary shall be payable monthly and in accordance with the Company’s normal payroll procedures. (Bonczek’s annual salary, as set forth above or as it may be increased
from time to time as set forth herein, shall be referred to hereinafter as “Base Salary”). 
  
 (b) Performance Bonus. In addition to the compensation otherwise payable to Bonczek pursuant to this Agreement, Bonczek shall be eligible to receive an
annual bonus (“Bonus”) pursuant to a performance bonus plan (the “Bonus Plan”) which may be established by the Company for its senior executive officers and which shall provide for bonus compensation to be payable based upon the
financial and other performance of the Company and Bonczek. Bonczek’s Bonus shall be in an amount up to forty-five percent (45%) of his Base Salary, provided that the Company, in computing Bonczek’s annual bonus, shall have the right to
make such adjustments as it may deem appropriate to reflect any mid-year changes in Bonczek’s salary or position pursuant to subsection 2(b) above. 

 (c) Long Term Stock Options. The Company has recommended that the Compensation Committee of the Board
grant Bonczek nonqualified stock options to purchase One Hundred Thousand (100,000) shares of the Company’s common stock at a price equal to the fair market value of the common stock on the date of grant, vesting monthly in an equal number of
shares over a period of four (4) years beginning August 17, 1999, and further subject to the terms set forth in this paragraph. Such options shall continue to vest so long as Bonczek remains an officer or on the payroll of the Company. In the event
of termination of both Bonczek’s appointment as an officer and on the payroll of the Company, no additional options shall vest, but stock options previously vested shall remain exercisable in accordance with the option agreement.
Notwithstanding the foregoing, if Bonczek’s is terminated under circumstances entitling Bonczek to severance benefits under the Severance Agreement (as herein defined below), Bonczek’s options shall continue to vest during the Continuation
Period (as defined in the Severance Agreement) following termination in accordance with the vesting schedule set forth in this paragraph and the option agreement, and shall remain exercisable for the remainder of the option term. All options will be
subject to the terms and conditions of the Trimeris, Inc. Amended and Restated Stock Incentive Plan. 
  
 (d) Relocation Expenses. If Bonczek decides to relocate his primary residence to the Raleigh/Durham/Chapel Hill area during the term of this Agreement,
the Company shall reimburse Bonczek for all conventional and reasonable relocation expenses. In addition, the Company shall also pay Bonczek an additional amount of up to Twenty-Five Thousand dollars ($25,000.00) for miscellaneous expenses and
charges not capable of being itemized. 
  
 (e) Reimbursement of
Lost Income. In consideration of Bonczek forgoing the supplemental income and career enhancement opportunities normally attendant to him, Company agrees to award Bonczek upon execution of this Agreement, a one time payment of Sixteen Thousand
dollars ($16,000.00). 
  
 4. Benefits During the Term. 
  
 (a) During the Term, Bonczek shall not be eligible to participate in any
life, health and long-term disability insurance programs, pension and retirement programs, stock option and other incentive compensation programs, and other fringe benefit programs made available to senior executive employees of the Company from
time to time. However, Bonczek shall be entitled to receive such other fringe benefits as may be granted to him from time to time by the Company’s Board of Directors. 

 (b) During the Term, Bonczek shall be allowed four (4) weeks of vacation with pay and leaves of absence
with pay. 
  
 (c) During the Term, the Company shall reimburse
Bonczek for reasonable business expenses incurred in performing Bonczek’s duties and promoting the business of the Company, including, but not limited to, reasonable entertainment expenses, travel and lodging expenses, following presentation of
documentation in accordance with the Company’s business expense reimbursement policies. 
  
 5. Term; Termination. As used herein, the phrase “Term” shall mean the period commencing on the Effective Date and ending on the same date two (2) years later; provided, however, that as of the expiration
date of each of (i) the initial Term and (ii) if applicable, any Renewal Period (as defined below), the Term shall automatically be extended for a two (2) year period (each a “Renewal Period”) unless either the Company or Bonczek provides
two (2) months’ written notice to the contrary. Notwithstanding the foregoing, the Term shall expire on the first to occur of the following: 
  
 (a) Reassignment. The Company may, at any time and without prior notice, terminate Bonczek’s appointment as an officer for the purpose of reassigning
Bonczek to a lesser capacity so long as such reassignment satisfies the conditions of a Permitted Reassignment pursuant to subsection 2(b)(ii) of this Agreement. Upon such Permitted Reassignment, Bonczek’s Term hereunder shall expire on the
last day of the Protected Period. 
  
 (b) Termination by the
Company. Notwithstanding anything to the contrary in this Agreement, whether express or implied, the Company may, at any time, terminate Bonczek’s appointment (as an officer or otherwise) for any reason other than Cause, Death or Disability by
giving Bonczek at least 60 days’ prior written notice of the effective date of termination. Company may terminate Employee’s appointment (as an officer or otherwise) for Cause, Death or Disability without prior notice, except that Bonczek
may not be terminated for substantial and willful failure to perform specific and lawful directives of the CEO and CSO, as reasonably determined by the CEO and CSO, unless and until the CEO and CSO has given him reasonable written notice of his
intended actions and specifically describing the alleged events, activities or omissions giving rise thereto and with respect to those events, activities or omissions for which a cure is possible, a reasonable opportunity to cure such breach; and
provided further, however, that for purposes of determining whether Cause is present, no act or failure to act by Bonczek shall be considered “willful” if done or omitted to be done by Bonczek in good faith and in the reasonable belief
that such act or omission was in the best interest of the Company and/or required by applicable law. The terms “Cause” and “Disability” shall have the meaning given them under the Severance Agreement. 

 (c) Termination by Bonczek. In the event that Bonczek’s appointment (as an officer or otherwise)
with the Company is voluntarily terminated by Bonczek, the Company shall have no further obligation hereunder from and after the effective date of termination except as may be provided in the Severance Agreement (as herein defined below) and the
Company shall have all other rights and remedies available under this Agreement or any other agreement and at law or in equity. Bonczek shall give the Company at least 30 days’ advance written notice of his intention to terminate his
appointment hereunder. 
  
 (d) Salary and Benefits Upon
Termination. In the event of termination of appointment (as an officer or otherwise), Bonczek shall receive all regular Base Salary due up to the date of termination, and if it has not previously been paid to Bonczek, Bonczek shall be paid any Bonus
to which Bonczek had become entitled under the Bonus Plan prior to the effective date of such termination and the Company shall have no further obligation hereunder from and after the effective date of termination except as may be provided in the
Severance Agreement and the Company shall have all other rights and remedies available under this Agreement or any other agreement and at law or in equity. Bonczek’s stock options with respect to the Company’s stock shall be subject to the
terms of the Trimeris, Inc. Amended and Restated Stock Incentive Plan and applicable option agreements thereunder, or any successor plans and agreements, which are not part of this Agreement. Bonczek’s right to severance benefits, if any, shall
be governed by the terms of the Separation and Severance Agreement attached hereto as Exhibit B (the “Severance Agreement”); provided, however, Bonczek, shall be entitled to de novo review of any material violation of the Severance
Agreement, or denial of any claim, or eligibility for any claim thereunder exclusively as provided in the Resolution of Dispute provisions of Section 12 of this Agreement. 
  
 (e) Agreement. The Severance Agreement is incorporated in this Agreement by reference and is hereby made a part of this
Agreement as if fully set forth herein. 
  
 6. Confidential Information,
Non-Solicitation and Non-Competition. 
  
 (a) During the Term and
at all times thereafter, Bonczek shall not, except as may be required to perform his duties hereunder or as required by applicable law, disclose to others or use, whether directly or indirectly, any Confidential Information regarding the Company.
“Confidential Information” shall mean information about the Company, its subsidiaries and affiliates, and their respective clients and customers that is not available to the general public and that was learned by Bonczek in the course of
his appointment by the Company (as an officer or otherwise), including (without limitation) (i) any proprietary knowledge, trade secrets, ideas, processes, formulas, cell lines, sequences, developments, designs, assays and techniques, data,
formulae, and client and customer lists and all papers, resumes, records (including computer records), (ii) information regarding plans for research, development, new products, 

 marketing and selling, business plans, budgets and unpublished financial statements, licenses, prices and costs,
suppliers and customers (iii) information regarding the skills and compensation of other employees of Company and (iv) the documents containing such Confidential Information. Bonczek acknowledges that such Confidential Information is specialized,
unique in nature and of great value to the Company, and that such information gives the Company a competitive advantage. Upon the termination of his appointment for any reason whatsoever, Bonczek shall promptly deliver to the Company all documents,
slides, computer tapes and disks (and all copies thereof) containing any Confidential Information. 
  
 (b) During the Term and for two (2) years thereafter, Bonczek shall not, directly or indirectly in any manner or capacity (e.g., as an advisor, principal,
agent, partner, officer, director, shareholder, employee, member of any association or otherwise) engage in, work for, consult, provide advice or assistance or otherwise participate in any activity which is competitive with the business of the
Company which is worldwide (“Competing Business” or “Competitor”). Bonczek further agrees that during such period he will not assist or encourage any other person in carrying out any activity that would be prohibited by the
foregoing provisions of this Section 6 if such activity were carried out by Bonczek and, in particular, Bonczek agrees that he will not induce any employee of the Company to carry out any such activity; provided, however, that the “beneficial
ownership” by Bonczek, either individually or as a member of a “group,” as such terms are used in Rule 13d of the General Rules and Regulations under the Securities Exchange Act of 1934, of not more than five percent (5%) of the
voting stock of any publicly held corporation shall not be a violation of this Agreement. It is further expressly agreed that the Company will or would suffer irreparable injury if Bonczek were to compete with the Company or any subsidiary or
affiliate of the Company in violation of this Agreement and that the Company would by reason of such competition be entitled to injunctive relief in a court of appropriate jurisdiction. 
  
 “Competing Business” is defined as the business of the discovery, development, testing, manufacturing, and/or
marketing therapeutic components for the treatment of human viral diseases based on a viral fusion protein target and any other business in which the Company may engage or propose to engage during the term of this Agreement. 
  
 (c) During the Term and for two (2) years thereafter, Bonczek shall not,
directly or indirectly, influence or attempt to influence customers or suppliers of the Company or any of its subsidiaries or affiliates, to divert their business to any Competitor of the Company. 
  
 (d) Bonczek recognizes that he will possess confidential information about
employees of the Company relating to their education, experience, skills, abilities, compensation and benefits, and 

 interpersonal relationships with customers of the Company. Bonczek recognizes that the information he will possess about
these employees is not generally known, is of substantial value to the Company in developing its business and in securing and retaining customers, and will be acquired by him because of his business position with the Company. Bonczek agrees that,
during the Term, and for a period of two (2) years thereafter, he will not, directly or indirectly, solicit or recruit any employee of the Company for the purpose of being employed by him or by any Competitor of the Company on whose behalf he is
acting as an agent, representative or employee and that he will not at any time convey any such confidential information or trade secrets about other employees of the Company to any other person. 
  
 (e) Bonczek agrees and understands that Company has received, and in the
future will receive, from third parties confidential or proprietary information (“Third Party Information”) subject to a duty on Company’s part to maintain the confidentiality of such information and to use it only for certain limited
purposes. During the Term and thereafter, Bonczek will hold Third Party Information in the strictest of confidence and will not disclose (to anyone other than Company personnel who need to know such information in connection with their work for
Company), or use, except in connection with any work for Company, Third Party Information unless expressly and specifically authorized to do so prior to any proposed disclosure by an officer of Company. 
  
 (f) Inventions: 
  
 (i) Assignment. Bonczek hereby assigns to Company all his right, title and
interest in and to any and all inventions (and all patent rights, copyright, trade secret rights and all other rights throughout the world in connection therewith, whether or not patentable or registerable under copyright, trademark or similar
statutes), together with all goodwill associated therewith, (all of the foregoing being hereinafter referred to collectively as “Proprietary Rights”), made, conceived, reduced to practice or learned by Bonczek, either alone or jointly with
others, during his period of appointment or engagement with Company. Proprietary Rights assigned under this Section 6 are hereinafter referred to as “Company Inventions”. Bonczek agrees to assist Company in every necessary way to obtain or
enforce any patents, copyrights or any proprietary rights relating to Company Inventions and to execute all documents and applications necessary to vest in Company’s full legal title to such Company Inventions, and Bonczek agrees to continue
this assistance after the termination of his appointment or engagement with Company. Furthermore, Bonczek hereby designates and appoints Company and its officers and agents as his agents and attorneys-in-fact to execute and file any certificates,
applications or documents and to do all other lawful acts reasonably necessary in the opinion of Company to protect Company’s rights in Company Inventions. Bonczek expressly acknowledges that the foregoing power of attorney is coupled with an
interest and is therefore irrevocable and will survive Bonczek’s termination of appointment or engagement, death or incompetency. 

 (ii) Government. Bonczek also will assign to or as directed by Company all his right, title and interest
in and to any and all Proprietary Rights, full title to which may required to be in the United States by a contract between Company and the United States or any of its agencies. 
  
 (iii) Independent Proprietary Rights. Notwithstanding anything in this Agreement to the contrary, Bonczek’s obligation
to assign or offer to assign Bonczek’s rights in Proprietary Rights to Company will not extend or apply to Proprietary Rights that Bonczek has developed entirely on Bonczek’s own time without using Company’s equipment, supplies,
facilities or trade secret information unless such Proprietary Right: (a) relates to Company’s business or actual demonstrably anticipated research or development or (b) results from any work performed by Bonczek for Company. Bonczek will bear
the burden of proof in establishing that the Proprietary Right qualifies for exclusion under this subsection 6(f)(iii). 
  
 (iv) Assignment of Company Inventions. Bonczek will assist Company in every proper way to obtain and from time to time enforce United States and foreign
Proprietary Rights related to Company Inventions in any and all countries. Bonczek’s obligation to assist Company with respect to Proprietary Rights relating to such Company Inventions will continue beyond the termination of Bonczek’s
appointment or engagement, but Company will compensate Bonczek at a reasonable rate after Bonczek’s termination for the time actually spent by Bonczek at Company’s request on such assistance. 
  
 Bonczek hereby waives and quitclaims to Company all claims, of any nature whatsoever, which
Bonczek may or may hereafter have for infringement, including past infringements, of any Proprietary Rights assigned hereunder to Company. 
  
 (v) Obligation to Keep Company Informed. During the period of Bonczek’s appointment or engagement, Bonczek will promptly disclose to Company fully
and in writing, and will hold in trust for the sole right and benefit of Company, any and all Proprietary Rights. In addition, after termination of Bonczek’s appointment or engagement, Bonczek will disclose all patent applications filed by
Bonczek within a year after termination of such appointment or engagement. 
  
 (vi) Prior Proprietary Rights. Proprietary Rights, if any, patented or unpatented, which Bonczek made prior to Bonczek’s commencement of appointment or engagement with Company are excluded from the scope of this
Agreement. To preclude any possible uncertainty, Bonczek has set forth on the attached Exhibit A, a complete list of all Proprietary Rights that Bonczek has, alone or jointly with others, conceived, developed or reduced to practice or caused to be
conceived, developed or reduced to practice prior to the commencement of Bonczek’s appointment or engagement with Company, that 

 Bonczek considers to be Bonczek’s property or the property of the third parties, and Bonczek wishes to have excluded
from the scope of this Agreement. If disclosure of any such Proprietary Right on Exhibit A would cause Bonczek to violate any prior confidentiality agreement with another party, Bonczek understands that he is not to list such Inventions in Exhibit A
but that he is to inform Company in writing that all such Proprietary Rights have not been listed for that reason. 
  
 (g) If it is determined by a court of competent jurisdiction in any state that any restriction in this Section 6 is excessive in duration or scope or is
unreasonable or unenforceable under the laws of that state, it is the intention of the parties that such restriction may be modified or amended by the court to render it enforceable to the maximum extent permitted by the law of that state.

  
 7. Return of Company Documents. In the event Bonczek leaves
the Company for whatever reason, Bonczek agrees to deliver to Company any and all laboratory notebooks, drawings, notes, memoranda, specifications, devices, software, databases, formulas, molecules, cells and documents, together with all copies
thereof, and any other material containing or disclosing any Company Inventions, Third Party Information or Confidential Information of Company. Bonczek further agrees that any property situated on Company’s premises and owned by Company
including disks and other storage media, filing cabinets or other work areas, is subject to inspection by Company personnel at any time, with or without notice, for the purpose of protecting Company’s rights and interests in its intellectual
property. 
  
 8. Miscellaneous. This Agreement shall also be
subject to the following miscellaneous considerations: 
  
 (a)
Bonczek and the Company each represent and warrant to the other that he or it has the authorization, power and right to deliver, execute, and fully perform his or its obligations under this Agreement in accordance with its terms. 
  
 (b) This Agreement (including attached Exhibits A and B) contains a complete
statement of all the arrangements between the parties with respect to Bonczek’s appointment by the Company, this Agreement supersedes all prior and existing negotiations and agreements between the parties concerning Bonczek’s appointment
as an officer (including but not limited to the Initial Consulting Agreement), and this Agreement can only be changed or modified pursuant to a written instrument duly executed by each of the parties hereto. 
  
 (c) If any provision of this Agreement or any portion thereof is declared
invalid, illegal, or incapable of being enforced by any court of competent jurisdiction, the remainder of such provisions and all of the remaining provisions of this Agreement shall continue in full force and effect. 

 (d) This Agreement shall be governed by and construed in accordance with the internal, domestic laws of
the State of North Carolina. 
  
 (e) The Company may assign this
Agreement to any direct or indirect subsidiary or parent of the Company or joint venture in which the Company has an interest, or any successor (whether by merger, consolidation, purchase or otherwise) to all or substantially all of the stock,
assets or business of the Company and this Agreement shall be binding upon and inure to the benefit of such successors and assigns. Except as expressly provided herein, Bonczek may not sell, transfer, assign, or pledge any of his rights or interests
pursuant to this Agreement. 
  
 (f) Any rights of Bonczek
hereunder shall be in addition to any rights Bonczek may otherwise have under benefit plans, agreements, or arrangements of the Company to which he is a party or in which he is a participant. Provisions of this Agreement shall not in any way
abrogate Bonczek’s rights under such other plans, agreements, or arrangements. 
  
 (g) For the purpose of this Agreement, notices and all other communications provided for in this Agreement shall be in writing and shall be deemed to have been duly given when delivered or mailed by United States
certified or registered mail, return receipt requested, postage prepaid, addressed to the named Bonczek at the address set forth below under his signature; provided that all notices to the Company shall be directed to the attention of the CEO and
CSO with a copy to the Secretary of the Company, or to such other address as either party may have furnished to the other in writing in accordance herewith, except that notice of change of address shall be effective only upon receipt. 
  
 (h) Section headings in this Agreement are included herein for convenience of
reference only and shall not constitute a part of this Agreement for any other purpose. 
  
 (i) Failure to insist upon strict compliance with any of the terms, covenants, or conditions hereof shall not be deemed a waiver of such term, covenant, or condition, nor shall any waiver or relinquishment of, or
failure to insist upon strict compliance with, any right or power hereunder at any one or more times be deemed a waiver or relinquishment of such right or power at any other time or times. 
  
 (j) This Agreement may be executed in several counterparts, each of which
shall be deemed to be an original but all of which together will constitute one and the same instrument. 
  
 9. Legal and Equitable Remedies. Because Bonczek’s services are personal and unique, and because Bonczek will have access to and become acquainted
with Proprietary and Confidential 

 Information of Company, Company will have the right to enforce this Agreement and any of its provisions by injunction,
specific performance or other equitable relief in any court of competent jurisdiction, without prejudice to any other rights and remedies that Company may have for a breach of this Agreement. 
  
 10. Survival of Provisions. The executory provisions of this Agreement will
survive the termination of this Agreement or the assignment of this Agreement by Company to any successor in interest or other assignee. 
  
 11. Resolution of Disputes. Except as otherwise specifically provided in Sections 8 and 10 of the Severance Agreement attached hereto, any dispute or
controversy arising under or in connection with this Agreement and Severance Agreement shall be settled exclusively by arbitration administered by the American Arbitration Association and conducted before a panel of three arbitrators in Raleigh,
Wake County, North Carolina, all in accordance with its Commercial Arbitration rules then in effect. The Company and Bonczek hereby agree that the arbitrator will not have the authority to award punitive damages, damages for emotional distress or
any other damages that are not contractual in nature. Judgment shall be final and binding upon the parties and judgement may be entered on the arbitrator’s award in any court having jurisdiction; provided, however, that (a) the Company shall be
entitled to seek a restraining order or injunction in any court of competent jurisdiction to prevent any violation or the continuation thereof, of the provisions of Section 6 of this Agreement, and Bonczek consents that such restraining order or
injunction may be granted without the necessity of the Company’s posting any bond except to the extent otherwise required by applicable law; and (b) notwithstanding anything in the Severance Agreement to the contrary, Bonczek, shall be entitled
by arbitration to seek de novo review of any material violation of the Severance Agreement or any denial of a claim or obligation to pay a claim thereunder. 
  
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above written. 
  

							
	ROBERT R. BONCZEK	 	COMPANY: TRIMERIS, INC.
				
	BY:	 	 /S/ ROBERT R. BONCZEK

	 	BY:	 	 /S/ DANI P. BOLOGNESI

	TITLE:	 	ACTING CHIEF ADMINISTRATIVE	 	NAME:	 	DANI P. BOLOGNESI, PH.D
	 	 	 OFFICER AND ACTING CHIEF FINANCIAL
 OFFICER
	 	 	 	 CHIEF EXECUTIVE OFFICER AND CHIEF
 SCIENTIFIC
OFFICER

 EXHIBIT A 
  
 TO 
  
 EXECUTIVE AGREEMENT 
  
 1. The following is a complete list of all inventions or improvements relevant to the subject matter of my appointment or engagement by the Company that have been made or conceived or first reduced to practice by me
alone or jointly with others prior to my appointment or engagement by the Company and therefore should be excluded from the coverage of this Agreement: 
  
  ̈  Additional sheets attached.

  
 x  No pertinent
inventions or improvements. 
  
  ̈  Due to confidentiality agreements with one or more prior employers, I cannot disclose certain inventions that would otherwise be included on the above-described
list. 
  
 2. I propose to bring to my appointment or engagement
the following devices, materials and documents of a former employer or other person to whom I have an obligation of confidentiality and that are not generally available to the public. These materials and documents may be used in my appointment or
engagement pursuant to the express written authorization of my former employer or such other person (a copy of which is attached hereto). If no such authorization is in place, I will consult with the Company management to determine what steps should
be taken to protect the interests of all parties concerned: 
  

			
		
	___________________________________________	 	 
		
	___________________________________________	 	 
		
	___________________________________________	 	 
		
	___________________________________________	 	 

  ̈  Additional sheets attached. 
  
 x  No material. 
  
 Date: 7 January 2000

  

	
	ROBERT R. BONCZEK:
	
	 /S/ ROBERT R. BONCZEK

	Robert R. Bonczek

 EXHIBIT B TO EXECUTIVE AGREEMENT 
  
 EXECUTIVE SEPARATION AND SEVERANCE AGREEMENT 
  
 THIS SEPARATION AND SEVERANCE AGREEMENT (the “Severance Agreement”) is made a part of that Executive Agreement
(the “Agreement”), entered into and effective as of the 2nd day of September, 1999, by and between ROBERT R. BONCZEK, an individual resident of the State of Delaware (“Bonczek”), and TRIMERIS, INC., a Delaware corporation (the
“Company”). 
  
 W I T N E S S E T H: 

 
 WHEREAS, the Company desires to provide for severance benefits under the
terms and conditions set forth herein; and 
  
 WHEREAS, this
Severance Agreement constitutes part of the Agreement and is incorporated therein by reference and fully set forth therein. 
  
 COVENANTS 
  
 NOW, THEREFORE, in consideration of the premises, mutual promises contained herein, and other valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, the parties agree as follows: 
  
 1.
Certain Definitions. The following terms shall have the meanings set forth herein. 
  
 (a) “Administrator” shall mean the Company. The Company shall also be the “named fiduciary” hereunder. The Company shall have the authority to designate one or more of its officers, employees or
directors to act on its behalf in administering this Severance Agreement. 
  
 (b) “Base Salary” shall mean Bonczek’s regular pay (in the form of salary or fees, as the case may be) at the time of termination. Base Salary shall not include bonus or incentive plans, overtime pay,
relocation allowances or the value of any other benefits for which Bonczek may be eligible. 

 (c) “Good Reason” shall mean, without the express written consent of Bonczek, the occurrence of
any of the following events unless such events are fully corrected within 30 days following written notification by Bonczek to the Company that he intends to terminate his appointment as an officer hereunder for one of the reasons set forth below:

  
 (i) a material breach by the Company of any provision of the
Agreement or Severance Agreement, including, but not limited to, the assignment to Bonczek of any duties inconsistent with Bonczek’s position in the Company or a material adverse alteration in the nature or status of Bonczek’s
responsibilities, except for a Permitted Reassignment as permitted in subsection 2(b) of the Agreement; 
  
 (ii) the Company’s requiring Bonczek to be based anywhere other than the metropolitan area where the Company is currently located; and 
  
 (iii) the occurrence of a “Change in Control” as defined below.

  
 For purposes of this Agreement a “Change in Control”
shall mean an event as a result of which: (i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934 (the “Exchange Act”)), is or becomes the “beneficial owner” (as defined
in Rule 13d-3 under the Exchange Act, except that a person shall be deemed to have “beneficial ownership” of all securities that such person has the right to acquire, whether such right is exercisable immediately or only after the passage
of time), directly or indirectly, of more than 50% of the total voting power of the voting stock of the Company; (ii) the Company consolidates with, or merges with or into another corporation or sells, assigns, conveys, transfers, leases or
otherwise disposes of all or substantially all of its assets to any person, or any corporation consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which the outstanding voting stock of the Company
is changed into or exchanged for cash, securities or other property, other than any such transaction where (A) the outstanding voting stock of the Company is changed into or exchanged for (i) voting stock of the surviving or transferee corporation
or (ii) cash, securities (whether or not including voting stock) or other property, and (B) the holders of the voting stock of the Company immediately prior to such transaction own, directly or indirectly, not less than 50% of the voting power of
the voting stock of the surviving corporation immediately after such transaction; or (iii) during any period of two consecutive years, individuals who at the beginning of such period constituted the Board of the Company (together with any new
directors whose election by such Board or whose nomination for election by the stockholders of the Company was approved by a vote of 66 2/3% of the directors then still in office who were either directors at the beginning of such period or whose election or nomination for election was previously so approved) cease for any reason to constitute a majority of the
Board of the Company then in office; or (iv) the Company is liquidated or dissolved or adopts a plan of liquidation, provided, however, that a Change in Control shall 

 not include any going private or leveraged buy-out transaction which is sponsored by Bonczek or in which Bonczek acquires
an equity interest materially in excess of his equity interest in the Company immediately prior to such transaction (each of the events described in (i), (ii), (iii) or (iv) above, except as provided otherwise by the preceding clause being referred
to herein as a “Change in Control”). In the event of a sale of the assets or stock of the Company, Bonczek shall have the option of electing to terminate his appointment or engagement due to a Change in Control and receive such severance
benefits or electing to remain employed under the terms of this Severance Agreement, but not both. Bonczek’s right to terminate his appointment or engagement for Good Cause due to any “Change in Control” must be exercised within sixty
(60) days after receiving written notice or his receiving actual knowledge of such Good Cause. 
  
 (d) “Cause” shall mean: 
  

	 	(i)	fraud, misappropriation, embezzlement, or other act of material misconduct against the Company or any of its affiliates; 

  

	 	(ii)	substantial and willful failure to perform specific and lawful directives of the CEO and CSO; 

  

	 	(iii)	willful and knowing violation of any rules or regulations of any governmental or regulatory body, which is materially injurious to the financial condition of the Company;

  

	 	(iv)	conviction of or plea of guilty or nolo contendere to a felony; or 

  

	 	(v)	a material breach of the terms and conditions of the Agreement; 

  
 provided, however, that with regard to subparagraphs (ii) and (v) above, Bonczek may not be terminated for Cause unless and until the CEO and CSO have given him
reasonable written notice of their intended actions and specifically describing the alleged events, activities or omissions giving rise thereto and with respect to those events, activities or omissions for which a cure is possible, a reasonable
opportunity to cure such breach; and provided further, however, that for purposes of determining whether any such Cause is present, no act or failure to act by Bonczek shall be considered “willful” if done or omitted to be done by Bonczek
in good faith and in the reasonable belief that such act or omission was in the best interest of the Company and/or required by applicable law. 

 (e) “Disability” shall mean that as a result of Bonczek’s incapacity due to physical or
mental illness (as determined in good faith by a physician acceptable to the Company and Bonczek), Bonczek shall have been absent from the performance of his duties with the Company for 120 consecutive days during any twelve (12) month period or if
a physician acceptable to the Company and Bonczek advises the Company that it is likely that Bonczek will be unable to return to the performance of his duties for 120 consecutive days during the succeeding twelve (12) month period. 
  
 2. Responsibility for Benefits. The Company will pay the entire cost of all
benefits provided under this Severance Agreement, solely from its general assets. The benefits made available by this Severance Agreement are “unfunded,” and Bonczek is not required or permitted to make any contribution with respect to
this Severance Agreement. 
  
 3. Payment of Benefits. In the event
Bonczek’s appointment as an officer of the Company is terminated (a) by the Company other than for Cause, Disability, Death or Permitted Reassignment, or (b) by Bonczek for Good Reason (as defined herein), Bonczek shall receive the following
severance benefits upon his satisfaction of the condition in Section 4 hereof: (i) his Base Salary during the period commencing on the effective date of such termination and ending on the second anniversary of the date of such termination or, if
earlier, the last day of the Protected Period (the “Continuation Period”), as if Bonczek were still employed or providing services to the Company, as the case may be, during the Continuation Period. 
  
 4. Conditions to Receipt of Benefits. Upon the occurrence of an event
described in Section 3 above, Bonczek will be eligible for severance benefits hereunder only if Bonczek executes and delivers to the Company a Settlement Agreement and Release in the form of Exhibit 1 attached hereto and made a part hereof.

  
 5. Termination Events Not Covered; Termination of this
Severance Agreement. Notwithstanding anything to the contrary contained herein, the Company shall not pay Bonczek severance benefits under this Severance Agreement if: 
  
 (a) Bonczek dies during the Term; 
  
 (b) Bonczek’s appointment or engagement is terminated for Cause or Disability; 

 (c) Bonczek’s appointment as an officer is terminated in a Permitted Reassignment;

  
 (d) Bonczek terminates his appointment with
the Company for a reason other than Good Reason as defined herein; 
  
 (e) Bonczek revokes his agreement to release the Company from any and all claims related to his appointment pursuant to the Settlement Agreement and Release executed in satisfaction of Section 4 hereof; or 

 
 This Severance Agreement shall terminate and be of no further force or effect upon the
occurrence of an event described in paragraphs (a), (b), (d) or (e) of this Section. Following an event described in paragraph (c) of this Section, this Severance Agreement shall terminate and be of no further force or effect at the end of the
Protected Period unless Bonczek becomes entitled to severance benefits pursuant to Section 3 of this Severance Agreement prior to the end of such Period. 
  
 6. How Severance Benefits Are Paid. The Company will pay severance benefits in installments through the Company’s regular payroll procedure according
to Bonczek’s pay schedule at the time of termination of appointment; provided however, the Administrator shall have the discretion to cause the Company to pay all severance benefits in a lump sum payment, or to cause the Company to postpone
commencement of benefits until the eighth (8th) day following Bonczek’s execution of the Settlement Agreement and Release. Bonczek’s severance benefits may be subject to mandatory withholding, including federal, state and local income
taxes, as well as FICA and withholding for applicable insurance premiums. 
  
 7. Administration. The Administrator shall have all powers necessary or helpful to administering this Severance Agreement in all its details, and shall have full discretionary authority in exercising such powers. This
authority includes, but is not limited to, the power: 
  
 (a) To
make rules and regulations for the administration of this Severance Agreement; 
  
 (b) To make any finding of fact necessary or appropriate for any purpose under this Severance Agreement, including, but not limited to, the determination of eligibility for and the amount of any benefit payable under
this Severance Agreement; and 

 (c) To interpret the terms and provisions of this Severance Agreement and to determine any and all
questions arising out of this Severance Agreement or in connection with its administration. This authority shall include, but is not limited to, the right to remedy or resolve possible ambiguities, inconsistencies or omissions, by general rule or
particular decision. 
  
 (d) The Administrator shall exercise the
powers conferred by this Severance Agreement in its sole and absolute discretion, and all its acts and determinations will be final and binding upon all interested parties subject to the de novo review by arbitration as provided in this Severance
Agreement and Agreement. 
  
 8. Benefit Claims and Appeal
Procedures. Bonczek has the right to make a written claim for benefits under this Severance Agreement. If all or part of Bonczek’s claim for benefits is denied, or if there is a dispute regarding Bonczek’s rights under this Severance
Agreement, the Administrator will notify Bonczek in writing of the reasons for the denial of Bonczek’s claim. The notice will refer to the appropriate provision of this Severance Agreement on which the denial or decision is based. The notice
will also describe how claims are reviewed and outline the steps for an appeal. Usually, the Administrator will give Bonczek written notice of its decision within ninety (90) days of receipt of the claim. However, the Administrator may in some cases
require additional time to complete its review, due to special circumstances. The Administrator will notify Bonczek if additional time is required for review of the claim. If Bonczek disagrees with the Administrator’s decision, Bonczek may
appeal and request a review of the case by the Administrator. Bonczek must request a review of the claim in writing within sixty (60) days after the Administrator notifies Bonczek of its decision. Bonczek’s request must state why Bonczek
disagrees with the decision, and Bonczek must include any information, questions or comments to support his appeal. Bonczek or his legal representative may review any documents related to the claim. The Administrator will review the appeal and
notify Bonczek of its decision within sixty (60) days after receipt of the appeal; however, the Administrator may in some cases require additional time to complete its review, due to special circumstances. The Administrator will notify Bonczek if
additional time is required for review of the appeal. The Administrator will notify Bonczek of its final decision and the reasons for the decision. 
  
 9. Additional Information Regarding this Severance Agreement. 
  
 (a) This Severance Agreement shall not be amended except by a written agreement executed by Bonczek and by an authorized officer of the
Company (other than Bonczek). 
  
 (b) The
Agreement and this Severance Agreement provides the sole and exclusive agreement concerning severance benefits for Bonczek in the event of a termination and replaces any and all prior plans, policies and practices relating to severance pay that may
exist now or may have existed in the past. 

 (c) To the extent not preempted by ERISA, the Agreement and this Severance Agreement shall be governed by
and construed according to the laws of the State of North Carolina. 
  
 (d) If a provision of this Severance Agreement shall be held illegal or invalid, the legality or invalidity shall not affect the remaining provisions of this Severance Agreement, and this Severance Agreement shall be construed and enforced
as if the illegal or invalid provision had not been included. 
  
 (e) Bonczek acknowledges that no representation, promise or inducement has been made other than as set forth in the Agreement and this Severance Agreement, and that he does not enter into this Agreement and Severance Agreement in reliance
upon any representation, promise or inducement not set forth herein and the Agreement. The Agreement and this Severance Agreement supersedes all prior negotiations and understandings of any kind with respect to the subject matter and contains all of
the terms and provisions of the agreement between Bonczek and the Company with respect to the subject matter hereof. Any representation, promise or condition, whether written or oral, not specifically incorporated herein, shall be of no binding
effect. 
  
 (f) Capitalized terms used in this Severance Agreement
shall have the meanings specified in the Agreement, unless expressly provided otherwise herein. 
  
 10. Bonczek’s Rights Under ERISA. As a participant under this Severance Agreement, Bonczek is entitled to certain rights and protections under ERISA.
Bonczek may examine all documents relating to the Severance Agreement without charge. These may include annual financial reports, plan descriptions and all other official documents filed with the United States Department of Labor (if any). Bonczek
may obtain copies of documents relating to this Severance Agreement and certain other information by writing to the Administrator. The Administrator may impose a reasonable charge for the copies. In addition to creating rights for Bonczek as a
participant under this Severance Agreement, ERISA imposes certain duties on the people who are responsible for operating this Severance Agreement. These people are called “fiduciaries.” The fiduciaries have a duty to operate the Severance
Agreement prudently and in the interest of Bonczek. The Company may not terminate Bonczek’s appointment or engagement or otherwise discriminate against Bonczek in any way to prevent him from obtaining a severance benefit or exercising rights
under ERISA. Under ERISA, Bonczek may take the following steps to enforce his rights: (a) if Bonczek requests certain materials from the administrator regarding this Severance Agreement and does not receive them within 30 days, Bonczek may file suit
in a federal court; in such a case, the court may require the Administrator to provide the materials and pay Bonczek up to $100 a day until Bonczek 

 receives the materials, unless the materials were not sent due to reasons beyond the control of the Administrator; (b) if
Bonczek’s claim for benefits is denied or ignored in whole or in part, Bonczek may file suit in federal court; (c) if Bonczek is discriminated against for pursuing a benefit or exercising ERISA rights, Bonczek may seek help from the United
States Department of Labor or file suit in a federal court. If Bonczek files a suit, the court will decide who should pay court costs and legal fees. If Bonczek has any questions about this statement or about ERISA rights, Bonczek should contact the
Administrator. Bonczek may also contact the nearest area office of the Pension and Welfare Benefit Administration, United States Department of Labor. 
  
 11. Miscellaneous Information About this Severance Agreement. This section provides general information about this Severance Agreement required by the
Employee Retirement Income Security Act of 1974 (“ERISA”). Participation in this Severance Agreement is subject to the execution by Bonczek of a Settlement Agreement and Release with the Company. This Agreement shall not be construed in
any manner to give any Company employee other than Bonczek the right to severance benefits upon termination of appointment. 
  

			
	Plan Sponsor:	  	Trimeris, Inc.
		
	Tax ID Number:	  	56-6017737
		
	Plan Name:	  	Trimeris, Inc. 1999 Executive Agreement and Separation and Severance Plan
		
	Plan Number:	  	            
		
	Plan Year:	  	Calendar year
		
	Plan Type:	  	Welfare benefit plan
		
	Effective Date:	  	September 2, 1999
		
	 Agent For Service
 of Legal Process:
	  	Trimeris, Inc.
		
	Attention:	  	Secretary

  
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK. SIGNATURE PAGE TO FOLLOW.] 

 IN WITNESS WHEREOF, the parties hereto have executed this Severance Agreement under seal as of the date
first set forth above (the individual party adopting the word “SEAL” as his seal). 
  

					
	COMPANY:	 	 
		
	TRIMERIS, INC.	 	 
			
	By:	 	 /s/ Dani P. Bologensi

	 	 
	 	 	Dani P. Bolognesi, Ph.D.	 	 
	 	 	Chief Executive Officer and	 	 
	 	 	Chief Scientific Officer	 	 
			
	 	 	ROBERT R. BONCZEK:	 	 
			
	 	 	 /s/ Robert R. Bonczek

	 	(SEAL)
	Name:	 	Robert R. Bonczek	 	 

 EXHIBIT 1 
  
 SETTLEMENT AGREEMENT AND RELEASE 
  
 THIS SETTLEMENT AGREEMENT AND RELEASE (“Settlement Agreement”) sets out the complete agreement and understanding between TRIMERIS, INC. (the
“Company”) and ROBERT R. BONCZEK (“Bonczek”) regarding the termination of Bonczek’s appointment as an officer with the Company. 
  
 I. RELEASE AND WAIVER: For and in consideration of the severance payments described in that certain Separation and Severance Agreement dated as of the 2nd
day of September, 1999 between the Company and Bonczek (the “Severance Agreement”), to be paid beginning no sooner than the eighth day following execution of this document, Bonczek hereby releases, waives and forever discharges the
Company, its parent, affiliates and subsidiaries, and all of its benefit plans, plan administrators, trustees, agents, subsidiaries, affiliates, employees, officers, shareholders, successors and assigns (hereafter the “Releasees”) from any
and all liability, actions, charges, causes of action, demands, damages, attorneys fees or claims for relief or remuneration of any kind whatsoever, whether known or unknown at this time, arising out of or in any way connected with Bonczek’s
appointment or engagement, or the termination of appointment or engagement, with the Company. These include, but are not limited to, any claim (including related attorneys’ fees and costs) under the Age Discrimination in Employment Act, Title
VII of the Civil Rights Act of 1964, the Americans with Disabilities Act, the Worker’s Adjustment and Retraining Notification Act, the Equal Pay Act, the Post Civil War Civil Rights Act, the Fair Labor Standards Act, the Family and Medical
Leave Act, the North Carolina Wage and Hour Act, the North Carolina Hazardous Chemicals Right to Know Act, the North Carolina Retaliatory Employment Discrimination Act, all as amended, or any other federal, state or local law or ordinance, and any
claim for benefits or other claims under the Employee Retirement Income Security Act of 1974, as amended (except as expressly provided below). This waiver, release and discharge also includes without limitation, any wrongful or unlawful discharge
claims, discipline or retaliation claims, any claims relating to any contract of employment, whether express or implied, any claims related to promotions or demotions, any claims for or relating to relocation, compensation including commissions,
short term or long term incentives, the Company’s Bonczek benefit plans and the management thereof (except as expressly provided below), any claims for defamation, slander, libel, invasion of privacy, misrepresentation, fraud, infliction of
emotional distress, any claims based on stress to the extent permitted by law, any claims for breach of any covenant of good faith and fair dealing, and any other claims relating to Bonczek’s appointment or engagement with the Company and
termination thereof. This Settlement Agreement does not apply to any claims or rights that may arise under the Age Discrimination in Employment Act after the date that this Settlement Agreement is signed. 

 Bonczek expressly waives all claims, including those which he/she does not know or suspect to exist in
his/her favor as of the date of this Settlement Agreement. As used in this Settlement Agreement, the parties understand the word “claims” to include all actions, claims and grievances, whether actual or potential, known or unknown, and
specifically but not exclusively including all claims against the Releasees arising from Bonczek’s appointment or engagement with the Company, the termination thereof or any other conduct by the Releasees occurring on or prior to the date
Bonczek signs this Settlement Agreement. All such claims are forever barred by this Settlement Agreement whether they arise in contract or tort or under a statute or any other law. 
  
 Bonczek also understands and agrees that this release extinguishes all claims, whether known or unknown, foreseen or
unforeseen, and expressly waives any rights or benefits under any law or judicial decision providing that, in substance, a general release does not extend to claims which a creditor does not know or suspect to exist in his/her favor at the time of
executing the release, which if known by him must have materially affected his/her settlement with a debtor. It is expressly understood and agreed by the parties that this Settlement Agreement is in full accord, satisfaction and discharge of any and
all doubtful and/or disputed claims by Bonczek against the Releasees, and that this Settlement Agreement has been signed with the express intent of extinguishing all claims, obligations, actions or causes of action as herein described. 

 
 Bonczek’s waiver of claims relating to or arising under the Employee
Retirement Income Security Act of 1974, as amended, or the Company’s 401(k) Plan, shall not be construed as a waiver of Bonczek’s right to receive his/her vested benefits under such plan, if any, in accordance with the terms and provisions
of such plan, or as a waiver of Bonczek’s right to reimbursement for covered expenses under and in accordance with the terms and provisions of the Company’s health or dental insurance plans, to the extent such covered expenses were
incurred during a period in which Bonczek was eligible to participate and in fact was participating in such plans. 
  
 II. VOLUNTARY AGREEMENT AND OTHER ACKNOWLEDGMENTS: Bonczek acknowledges that: 
  
 I have read this Settlement Agreement, and I understand its legal and binding effect. I am knowingly and voluntarily executing this
Settlement Agreement of my own free will. 

 The severance benefits under the Severance Agreement are in addition to and in excess of benefits to which I am otherwise
entitled. 
  
 I have had the opportunity to seek, and the Company has expressly
advised me to seek, legal counsel prior to signing this Settlement Agreement. 
  
 I have been given at least 45 days from the date I received this form to consider the severance benefits being offered to me and the terms of this Settlement Agreement. 
  
 At the beginning of that 45 day period, I also received a description of: (1) the class, unit, or group of individuals covered by the
severance and separation plan (if any), the eligibility factors for this program, and any time limits applicable to the program; and (2) the job titles and ages of all individuals being asked to execute this Settlement Agreement in exchange for
payment of severance benefits (if any) and the job titles and ages of all individuals in the same job classification or organizational unit who are not being asked to execute this Settlement Agreement. 
  
 I understand that in signing this Settlement Agreement, I am releasing the Releasees from any
and all claims I may have against them (except as expressly provided herein), including but not limited to claims under the Age Discrimination in Employment Act. 
  
 III. REVOCATION OF SETTLEMENT AGREEMENT: I understand that I can change my mind and revoke my signature on this Settlement
Agreement within seven days after signing it by hand delivering notice of such revocation to the Chairman of the Compensation Committee of the Company. I understand that if I revoke this Settlement Agreement, I will not be entitled to any severance
benefits under the Severance Agreement. I understand that, unless properly revoked by me during this seven-day period, the release and waiver in the first section above will become effective seven days after I sign the Settlement Agreement.

  
 IV. COMPLETE AGREEMENT: I acknowledge that no representation,
promise or inducement has been made other than as set forth in this Settlement Agreement, and that I do not enter into this Settlement Agreement in reliance upon any representation, promise or inducement not set forth herein. This Settlement
Agreement supersedes all prior negotiations and understandings of any kind with respect to the subject matter and contains all of the terms and provisions of agreement between Bonczek and the Company with respect to the subject matter hereof. Any
representation, promise or condition, whether written or oral, not specifically incorporated herein, shall be of no binding effect. 

 V. GOVERNING LAW: This Settlement Agreement shall be governed by the Employee Retirement Income Security
Act and, where applicable, the law of the State of North Carolina. 
  
 VI. SEVERABILITY: In the event any provision of this Settlement Agreement shall be held to be void, voidable, unlawful or, for any reason, unenforceable, the remaining portions shall remain in full force and effect. The unenforceability or
invalidity of a provision of this Settlement Agreement in one jurisdiction shall not invalidate or render that provision unenforceable in any other jurisdiction. If Bonczek’s release and waiver pursuant to Section I of this Settlement Agreement
is found to be unenforceable, however, Bonczek agrees that he/she will either sign a valid release and waiver of claims in favor of the Company and the Releasees or promptly return the severance benefits received by Bonczek. 
  
 VII. BINDING EFFECT: This Settlement Agreement is binding upon, and shall
inure to the benefit of, the parties and their respective heirs, executors, administrators, successors and assigns. 
  
 VIII. NO ADMISSIONS: This Settlement Agreement is not intended as, and shall not be construed, as an admission that the Company and Releasees or any of
them have violated any federal, state or local law, ordinance or regulation, breached any contract, or committed any wrong whatsoever against Bonczek. 
  
 AGREED AND UNDERSTOOD: 
  

									
	ROBERT R. BONCZEK:	 	 	 	 
			
	  

 Name: Robert R. Bonczek
	 	 	 	  

 Date

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