Document:

EX-10.16

 Exhibit 10.16 

CHANGE IN CONTROL AND SEVERANCE AGREEMENT    (CFO) 

This Change In Control and Severance Agreement (the “Agreement”) is made by and between Anaplan, Inc. (the
“Company”) and David H. Morton (the “Executive”), effective on the date of the Company’s signature below (the “Effective Date”). 

The Agreement provides certain change in control and severance protections to the Executive in connection with the involuntary termination of the
Executive’s employment under the circumstances described in the Agreement. 
 The Company and the Executive agree as follows: 

1. Term of Agreement. The Agreement will terminate on the earlier of: (i) the date on which all of the obligations under the
Agreement have been satisfied; or (ii) the date on which the Executive experiences a Non-Qualified Termination. 

2. At-Will Employment. The Company and the Executive acknowledge that the Executive’s
employment is and will continue to be at-will, as defined under applicable law, except if otherwise specifically provided under the employment agreement between the Company and the Executive dated
September 9, 2018 (the “Employment Agreement”) or any subsequently adopted written formal employment agreement between the Company and the Executive. 

3. Severance Benefits. 

(a) Non-CIC Qualified Termination. If the Executive is subject to a Non-CIC Qualified Termination, the Executive will be eligible to
receive the payments and benefits set forth in Section 3(a)(i) and 3(a)(ii) below. In addition, if the Executive is subject to a Non-CIC Qualified Termination and such termination is on account of the Executive’s death or Disability, then
the Executive shall also be entitled to receive the benefits set forth in Section 3(a)(iii) below. 
 (i) Salary Severance. The
Company will provide the Executive with severance payments over the 6 month period following the Non-CIC Qualified Termination in an aggregate amount equal to 50% of the Executive’s Base Salary; provided that if the Non-CIC Qualified
Termination is on account of the Executive’s death or Disability, the Executive still instead receive a one-time lump-sum payment equal to 50% of the
Executive’s Base Salary. However, if the Non-CIC Qualified termination occurs within the first twelve (12) months of services, the prior sentence will not apply, and the Company will instead provide the Executive with severance payments
over the 12 month period following the Non-CIC Qualified Termination in an aggregate amount equal to 100% of the Executive’s Base Salary; provided that if the Non-CIC Qualified Termination is on account of the Executive’s death or
Disability, the Executive still instead receive a one-time lump-sum payment equal to 100% of the Executive’s Base Salary. 

(ii) COBRA Payment. A lump-sum payment equal to a multiple of the monthly COBRA premium that
the Executive would be required to pay to continue group health coverage for the Executive and the Executive’s eligible covered dependents in effect on the date 

 
of termination of employment, based on the premium for the first month of COBRA coverage. The multiple of the monthly COBRA premium will be 6 unless a Non-CIC Qualified Termination occurs within
the first twelve (12) months of service, in which case the multiple will be 12. Such cash payment will be taxable and will be made regardless of whether the Executive elects COBRA continuation coverage. 

(iii) Equity Vesting. In the event the Non-CIC Qualified Termination is on account of the Executive’s death or Disability, then
all of the then-unvested shares subject to each of the Executive’s then-outstanding equity awards will immediately vest and, in the case of options and stock appreciation rights, will become exercisable (for avoidance of doubt, no more than
100% of the shares subject to the then-outstanding portion of an equity award may vest and become exercisable under this provision). In the case of equity awards with performance-based vesting, all performance goals and other vesting criteria will
be deemed achieved at the greater of actual performance or 100% of target levels. Unless otherwise required under the next following two sentences or, with respect to awards subject to Section 409A of the Code, under Section 5(b) below,
any restricted stock units, performance shares, performance units, and/or similar full value awards that vest under this paragraph will be settled on the 61st day following the Non-CIC Qualified Termination. 

(b) CIC Qualified Termination. If the Executive is subject to a CIC Qualified Termination, the Executive will be eligible to receive the
following payments and benefits from the Company: 
 (i) Salary Severance. A lump-sum payment
equal to 100% of the Executive’s Base Salary. 
 (ii) Bonus Severance. A lump-sum
payment equal to 100% of the Executive’s target annual bonus as in effect for the fiscal year in which the CIC Qualified Termination occurs. 

(iii) COBRA Payment. A lump-sum payment equal to 12 multiplied by the monthly COBRA premium
that the Executive would be required to pay to continue group health coverage for the Executive and the Executive’s eligible covered dependents in effect on the date of termination of employment, based on the premium for the first month of
COBRA coverage. Such cash payment will be taxable and will be made regardless of whether the Executive elects COBRA continuation coverage. 

(iv) Equity Vesting. All of the then-unvested shares subject to each of the Executive’s then-outstanding equity awards will
immediately vest and, in the case of options and stock appreciation rights, will become exercisable (for avoidance of doubt, no more than 100% of the shares subject to the then-outstanding portion of an equity award may vest and become exercisable
under this provision). In the case of equity awards with performance-based vesting, all performance goals and other vesting criteria will be deemed achieved at the greater of actual performance or 100% of target levels. Unless otherwise required
under the next following two sentences or, with respect to awards subject to Section 409A of the Code, under Section 5(b) below, any restricted stock units, performance shares, performance units, and/or similar full value awards that vest
under this paragraph will be settled on the 61st day following the CIC 

  
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Qualified Termination. For the avoidance of doubt, if the Executive’s Qualified Termination occurs prior to a Change in Control, then any unvested portion of the Executive’s
then-outstanding equity awards will remain outstanding for 3 months or the occurrence of a Change in Control (whichever is earlier) so that any additional benefits due on a CIC Qualified Termination can be provided if a Change in Control occurs
within 3 months following the Qualified Termination (provided that in no event will the Executive’s stock options or similar equity awards remain outstanding beyond the equity award’s maximum term to expiration). In such case, if no Change
in Control occurs within 3 months following a Qualified Termination, any unvested portion of the Executive’s equity awards automatically will be forfeited permanently on the 3-month anniversary of the
Qualified Termination without having vested. 
 (c) Termination other than a Qualified Termination. If the termination of
Executive’s employment with the Company is a Non-Qualified Termination, then the Executive will not be entitled to receive severance or other benefits under the Agreement, other than the accrued rights
described in Section 4 below. 
 (d) Non-Duplication of Payment or Benefits. If:
(i) the Executive’s Qualified Termination occurs prior to a Change in Control that qualifies Executive for severance payments and benefits under Section 3(a); and (ii) a Change in Control occurs within the 3-month period following Executive’s Qualified Termination that qualifies Executive for severance payments and benefits under Section 3(b), then (A) the Executive will cease receiving any further
payments or benefits under Section 3(a) and (B) the Executive will receive the payments and benefits under Section 3(b) instead but each of the payments and benefits otherwise payable under Section 3(b) will be
offset by the corresponding payments or benefits the Executive already received under Section 3(a). 
 (e) Death of the
Executive. If the Executive dies before all payments or benefits the Executive is entitled to receive under the Agreement have been paid, such unpaid amounts will be paid to the Executive’s designated beneficiary, if living, or otherwise to
the Executive’s personal representative in a lump-sum payment as soon as possible following the Executive’s death. 

(f) Exclusive Remedy. In the event of a termination of the Executive’s employment with the Company, the provisions of the Agreement
are intended to be and are exclusive and in lieu of any other rights or remedies to which the Executive may otherwise be entitled, whether at law, tort or contract, or in equity. The Executive will be entitled to no benefits, compensation or other
payments or rights upon termination of employment other than those benefits expressly set forth in the Agreement. Notwithstanding the foregoing, the Agreement shall not limit any rights the Executive has with respect to accelerated vesting of any
equity award under the applicable grant agreement or the applicable stock plan. 
 4. Accrued Compensation. On any termination of the
Executive’s employment with the Company, the Executive will be entitled to receive all expense reimbursements, accrued wages, and other benefits due to the Executive under any applicable Company-provided plan, policy or arrangement, including
any earned but unpaid bonus amount for the Company’s immediately preceding fiscal year. The Executive’s rights under this Section 4 shall survive the termination of this Agreement until all such rights have been satisfied. 

  
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 5. Conditions to Receipt of Severance. 

(a) Separation Agreement and Release of Claims. The Executive’s receipt of any severance payments or benefits upon the
Executive’s Qualified Termination under Section 3 is subject to the Executive signing and not revoking the Company’s then-standard separation agreement and release of claims (which may include an agreement not to disparage any member
of the Company, non-solicit provisions, and other standard terms and conditions) (the “Release” and such requirement, the “Release Requirement”), which must become effective
and irrevocable no later than the date specified by the Company in the Release (the “Release Deadline”); provided that the Release Deadline will be no later than 60 days following the Executive’s Qualified Termination. If the
Release does not become effective and irrevocable by the Release Deadline, the Executive will forfeit any right to severance payments or benefits under Section 3. In no event will severance payments or benefits under Section 3 be paid or
provided until the Release actually becomes effective and irrevocable. None of the severance payments and benefits payable upon such Executive’s Qualified Termination under Section 3 will be paid or otherwise provided prior to the 60th day
following the Executive’s Qualified Termination. Except to the extent that payments are delayed under Section 5(b), on the first regular payroll pay day following the 60th day following the Executive’s Qualified Termination, the
Company will pay or provide the Executive the severance payments and benefits that the Executive would otherwise have received under Section 3 on or prior to such date, with the balance of such severance payments and benefits being paid or
provided as originally scheduled. 
 (b) Section 409A. The Company intends that all payments and benefits provided
under the Agreement or otherwise are exempt from, or comply with, the requirements of Section 409A of the Code and any guidance promulgated under Section 409A of the Code (collectively, “Section 409A”)
so that none of the payments or benefits will be subject to the additional tax imposed under Section 409A, and any ambiguities herein will be interpreted in accordance with this intent. No payment or benefits to be paid to the Executive, if
any, under the Agreement or otherwise, when considered together with any other severance payments or separation benefits that are considered deferred compensation under Section 409A (together, the “Deferred Payments”), will be
paid or otherwise provided until the Executive has a “separation from service” within the meaning of Section 409A. If, at the time of the Executive’s termination of employment, the Executive is a “specified
employee” within the meaning of Section 409A, then the payment of any Deferred Payments that are subject to Section 409A will be delayed to the extent necessary to avoid the imposition of the additional tax imposed under
Section 409A, which generally means that the Executive will receive payment on the first payroll date that occurs on or after the date that is 6 months and 1 day following the Executive’s separation from service. Notwithstanding anything
to the contrary above, if the accelerated vesting and/or settlement of any restricted stock units or other awards under Section 3(b)(iv) would subject such awards to imposition of the additional tax imposed under Section 409A, then the
shares or property subject thereto shall be distributed or paid only at the time(s) and according to the schedule on which such distributions or payments were scheduled to be made under the original terms of the applicable award agreement(s). The
Company reserves the right to amend the Agreement as it considers necessary or advisable, in its sole discretion and without the consent of the Executive or any other individual, to comply with any provision required to avoid the imposition of the
additional tax imposed under Section 409A or to otherwise avoid income recognition under Section 409A prior to the actual payment of any benefits or imposition 

  
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of any additional tax. Each payment, installment, and benefit payable under the Agreement is intended to constitute a separate payment for purposes of U.S. Treasury Regulation Section 1.409A-2(b)(2). In no event will any member of the Company reimburse the Executive for any taxes that may be imposed on the Executive as a result of Section 409A. 

6. Limitation on Payments. 

(a) Reduction of Severance Benefits. If any payment or benefit that the Executive would receive from any Company member or any other
party whether in connection with the provisions herein or otherwise (the “Payment”) would: (i) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (ii) but for this
sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment will be equal to the Best Results Amount. The “Best Results Amount” will be either (x) the
full amount of such Payment or (y) such lesser amount as would result in no portion of the Payment being subject to the Excise Tax, whichever of the foregoing amounts, taking into account the applicable federal, state and local employment
taxes, income taxes and the Excise Tax, results in the Executive’s receipt, on an after-tax basis, of the greater amount. If a reduction in payments or benefits constituting parachute payments is
necessary so that the Payment equals the Best Results Amount, reduction will occur in the following order: reduction of cash payments; cancellation of accelerated vesting of stock awards; reduction of employee benefits. In the event that
acceleration of vesting of stock award compensation is to be reduced, such acceleration of vesting will be cancelled in the reverse order of the date of grant of the Executive’s equity awards. The Executive will be solely responsible for the
payment of all personal tax liability that is incurred as a result of the payments and benefits received under the Agreement, and the Executive will not be reimbursed by any member of the Company Group or any of their respective affiliates. 

(b) Determination of Excise Tax Liability. The Company will select a professional services firm to make all of the determinations
required to be made under these paragraphs relating to parachute payments. The Company will request that firm provide detailed supporting calculations both to the Company and the Executive prior to the date on which the event that triggers the
Payment occurs if administratively feasible, or subsequent to such date if events occur that result in parachute payments to the Executive at that time. For purposes of making the calculations required under these paragraphs relating to parachute
payments, the firm may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good faith determinations concerning the application of the Code. The Company and the Executive will furnish to the firm
such information and documents as the firm may reasonably request in order to make a determination under these paragraphs relating to parachute payments. The Company will bear all costs the firm may reasonably incur in connection with any
calculations contemplated by these paragraphs relating to parachute payments. Any such determination by the firm will be binding upon the Company and the Executive, and the Company will have no liability to the Executive for the determinations of
the firm. 

  
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 7. Definitions. The following terms referred to in the Agreement will have the following
meanings: 
 (a) “Base Salary” means the Executive’s annual base salary as in effect immediately prior to the
Executive’s Qualified Termination (or if the termination is due to a resignation for Good Reason based on a material reduction in base salary, then the Executive’s annual base salary in effect immediately prior to such reduction) or, if
the Executive’s Qualified Termination is a CIC Qualified Termination and such amount is greater, at the level in effect immediately prior to the Change in Control. 

(b) “Cause” means the occurrence of any of the following: (i) the Executive’s conviction of, or plea of “no
contest” to, a felony or any crime involving fraud or embezzlement; (ii) the Executive’s intentional misconduct; (iii) the Executive’s material failure to perform the Executive’s employment duties (other than as a
result of a mental or physical incapacity that results in or would reasonably be expected to result in the Executive’s Disability); (iv) the Executive’s unauthorized use or disclosure of any proprietary information or trade secrets of
the Company or any other member of the Company Group or any other party to whom the Executive owes an obligation of nondisclosure as a result of the Executive’s relationship with the Company; (v) an act of material fraud or dishonesty
against the Company or any other member of the Company Group; (vi) the Executive’s material violation of any policy of the Company or any other member of the Company Group or material breach of any written agreement with the Company or any
other member of the Company Group; or (vii) the Executive’s failure to cooperate with the Company or any other member of the Company Group in any investigation or formal proceeding. The Company will not terminate the Executive’s
employment for Cause without first providing the Executive with written notice specifically identifying the acts or omissions constituting the grounds for a Cause termination and, with respect to clauses (ii), (iii), (vi), and (vii), a reasonable
cure period of not less than 10 business days following such notice to the extent such events are curable (as determined by the Company). 

(c) “Change in Control” means the occurrence of any of the following events: 

(i) Change in Ownership of the Company. A change in the ownership of the Company which occurs on the date that any one person, or more
than one person acting as a group (“Person”), acquires ownership of the stock of the Company that, with the stock held by such Person, constitutes more than 50% of the total voting power of the stock of the Company; provided, that
for this subsection, the acquisition of additional stock by any one Person, who prior to such acquisition is considered to own more than 50% of the total voting power of the stock of the Company will not be considered a Change in Control. Further,
if the stockholders of the Company immediately before such change in ownership continue to retain immediately after the change in ownership, in substantially the same proportions as their ownership of shares of the Company’s voting stock
immediately prior to the change in ownership, direct or indirect beneficial ownership of 50% or more of the total voting power of the stock of the Company, such event shall not be considered a Change in Control under this clause (i). For this
purpose, indirect beneficial ownership shall include, without limitation, an interest resulting from ownership of the voting securities of one or more corporations or other business entities which own the Company, as the case may be, either directly
or through one or more subsidiary corporations or other business entities; or 

  
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 (ii) Change in Effective Control of the Company. Individuals who are members of the Board
(the “Incumbent Board”) cease for any reason to constitute at least a majority of the members of the Board over a period of 12 months; provided however that if the appointment or election (or nomination for election) of any new
Board member was approved or recommended by a majority vote of the members of the Incumbent Board then still in office, such new member shall, for purposes hereunder, be considered as a member of the Incumbent Board; or 

(iii) Change in Ownership of a Substantial Portion of the Company’s Assets. A change in the ownership of a substantial portion of
the Company’s assets which occurs on the date that any Person acquires (or has acquired during the 12-month period ending on the date of the most recent acquisition by such person or persons) assets from
the Company that have a total gross fair market value equal to or more than 50% of the total gross fair market value of all of the assets of the Company immediately prior to such acquisition or acquisitions; provided, however, that for purposes of
this subsection, the following will not constitute a change in the ownership of a substantial portion of the Company’s assets: (A) a transfer of assets by the Company to an entity, 50% or more of the total value or voting power of which is
owned, directly or indirectly, by the Company; or (B) a transfer of assets to a Person, that owns, directly or indirectly, 50% or more of the total value or voting power of all the then-outstanding stock of the Company. 

For this definition, gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of,
determined without regard to any liabilities associated with such assets. For this definition, Persons will be acting as a group if they are owners of a corporation that enters into a merger, consolidation, purchase or acquisition of stock, or
similar business transaction with the Company. 
 A transaction will not be a Change in Control unless the transaction qualifies as a change
in control event within the meaning of Section 409A (as defined below). 
 Further and for the avoidance of doubt, a transaction will
not constitute a Change in Control if: (i) its sole purpose is to change the state of the Company’s incorporation; or (ii) its sole purpose is to create a holding company that will be owned in substantially the same proportions by the
persons who held the Company’s securities immediately before such transaction. 
 (d) “Change in Control Period” means
the period beginning 3 months prior to the occurrence of a Change in Control and ending 12 months following the occurrence of a Change in Control. 

(e) “COBRA” means the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended. 

(f) “CIC Qualified Termination” means a Qualified Termination that occurs during a Change in Control Period. 

(g) “Code” means the Internal Revenue Code of 1986, as amended. 

  
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 (h) “Company Group” means the Company and each of its subsidiaries. 

(i) “Disability” means the Executive is, by reason of any medically determinable physical or mental impairment that can be
expected to result in death or can be expected to last for a continuous period of not less than 12 months, either: (i) unable to engage in any substantial gainful activity; or (ii) receiving income replacement benefits for a period of not
less than 3 months under an accident and health plan covering employees of the Company member that is employing the Executive. 
 (j)
“Good Reason” means the termination of the Executive’s employment with the Company or such other applicable member of the Company Group by the Executive in accordance with the next sentence after the occurrence of one or more
of the following events without the Executive’s express written consent: (i) a material reduction of the Executive’s duties, authorities, or responsibilities relative to the Executive’s duties, authorities, or responsibilities in
effect immediately prior to such reduction; provided that it will be considered a substantial reduction in duties and responsibilities if after a Change in Control, the Executive is not the Chief Financial Officer of the ultimate parent of the
resulting company and, if such Change in Control occurs after the Company’s IPO, if such ultimate parent is not a publicly traded company; (ii) a material reduction by the Company in the Executive’s rate of annual base salary;
provided, however, that, a reduction of annual base salary that also applies to substantially all other similarly situated employees of the Company will not constitute “Good Reason”; (iii) a material change in the geographic
location of the Executive’s primary work facility or location; provided, that a relocation of less than 35 miles from the Executive’s then present location will not be considered a material change in geographic location; or (iv) the
failure of the Company to obtain from any successor or transferee of the Company an express written and unconditional assumption of the Company’s obligations to the Executive under the Agreement. In order for the termination of the
Executive’s employment with the Company to be for Good Reason, the Executive must not terminate employment without first providing written notice to the Company of the acts or omissions constituting the grounds for “Good
Reason” within 90 days of the initial existence of the grounds for “Good Reason” and a cure period of 30 days following the date of written notice (the “Cure Period”), such grounds must not have been cured
during such time, and the Executive must terminate the Executive’s employment within 30 days following the last day of the Cure Period. 

(k) “IPO” shall mean the consummation of the first firm commitment underwritten public offering pursuant to an effective
registration statement under the Securities Act of 1933, as amended, covering the offer and sale by the Company of its equity securities, as a result of or following which the shares of common stock of the Company shall be publicly held. 

(l) “Non-CIC Qualified Termination” means a Qualified Termination that occurs outside of a Change in Control Period. 

(m) “Non-Qualified Termination” means a termination of the Executive’s employment
for any reason that is not a Qualified Termination. 

  
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 (n) “Qualified Termination” means a termination of the Executive’s
employment either: (A) due to the Executive’s death or Disability; (B) by the Company without Cause; or (C) by the Executive for Good Reason. 

8. Successors. 
 (a) The
Company’s Successors. Any successor (whether direct or indirect and whether by purchase, merger, consolidation, liquidation or otherwise) to all or substantially all of the Company’s business and/or assets must assume the obligations
under the Agreement and agree expressly to perform the obligations under the Agreement in the same manner and to the same extent as the Company would be required to perform such obligations in the absence of a succession. For all purposes under the
Agreement, the terms “Company” and “Company Group” will include any successor to their business and/or assets which executes and delivers the assumption agreement described in this Section 8(a) or which
becomes bound by the terms of the Agreement by operation of law. 
 (b) The Executive’s Successors. The terms of the Agreement
and all rights of the Executive under the Agreement will inure to the benefit of, and be enforceable by, the Executive’s personal or legal representatives, executors, administrators, successors, heirs, distributees, devisees, and legatees. 

9. Notice. 
 (a)
General. All notices and other communications required or permitted under the Agreement shall be in writing and will be effectively given: (i) upon actual delivery to the party to be notified; (ii) 1 business day after deposit with
a recognized overnight courier; or (iii) 3 business days after deposit with the U.S. Postal Service by first class certified or registered mail, return receipt requested, postage prepaid, addressed (A) if to the Executive, at the address
the Executive shall have most recently furnished to the Company in writing, (B) if to the Company, at the following address: 
 Anaplan,
Inc. 
 50 Hawthorne Street 

San Francisco, CA 94105 

Attention: VP Legal 
 E-mail: Gary.spiegel@anaplan.com 
 (b) Notice of Termination. Any termination by the Company for
Cause will be communicated by a notice of termination to the Executive, and any termination by the Executive for Good Reason will be communicated by a notice of termination to the Company, in each case given in accordance with
Section 9(a) of the Agreement. Such notice will indicate the specific termination provision in the Agreement relied upon, will set forth in reasonable detail the facts and circumstances claimed to provide a basis for termination under the
provision so indicated, and will specify the termination date (which will be not more than 30 days after the later of: (i) the giving of such notice; or (ii) the end of any applicable cure period). The failure by the Executive to include
in the notice any fact or circumstance that contributes to a showing of Good Reason will not waive any right of the Executive under the Agreement or preclude the Executive from asserting such fact or circumstance in enforcing the Executive’s
rights under the Agreement. 

  
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 10. Resignation. The termination of the Executive’s employment for any reason will
also constitute, without any further required action by the Executive, the Executive’s voluntary resignation from all officer and/or director positions held at any member of the Company, and at the Board’s request, the Executive will
execute any documents reasonably necessary to reflect such resignation. 
 11. Arbitration. Any controversy or claim arising out of or
relating to the Agreement, or any breach of the Agreement, remains subject to the Alternative Dispute Resolution Agreement signed as a condition of employment with the Company and attached as an exhibit to the Confirmatory Employment Letter. 

 12. Miscellaneous Provisions. 

(a) No Duty to Mitigate. The Executive will not be required to mitigate the amount of any payment contemplated by the Agreement, nor
will any such payment be reduced by any earnings that the Executive may receive from any other source. 
 (b) Waiver; Amendment. No
provision of the Agreement will be modified, waived or discharged unless the modification, waiver or discharge is agreed to in writing and signed by an authorized officer of the Company (other than the Executive) and by the Executive. No waiver by
either party of any breach of, or of compliance with, any condition or provision of the Agreement by the other party will be considered a waiver of any other condition or provision or of the same condition or provision at another time. 

(c) Headings. All captions and section headings used in the Agreement are for convenient reference only and do not form a part of the
Agreement. 
 (d) Entire Agreement. The Agreement, together with the Confirmatory Employment Letter and the Alternative Dispute
Resolution Agreement, constitutes the entire agreement of the parties hereto and supersedes in their entirety all prior representations, understandings, undertakings or agreements (whether oral or written and whether expressed or implied) of the
parties with respect to the subject matter hereof. 
 (e) Choice of Law. This Agreement will be governed by the laws of the State of
California without regard to California’s conflicts of law rules that may result in the application of the laws of any jurisdiction other than California. To the extent that any lawsuit is permitted under this Agreement, the Executive hereby
expressly consents to the personal and exclusive jurisdiction and venue of the state and federal courts located in California for any lawsuit filed against the Executive by the Company. 

(f) Severability. The invalidity or unenforceability of any provision or provisions of the Agreement will not affect the validity or
enforceability of any other provision hereof, which will remain in full force and effect. 

  
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 (g) Withholding. All payments and benefits under the Agreement will be paid less
applicable withholding taxes. The Company and the other members of the Company Group are authorized to withhold from any payments or benefits all federal, state, local and/or foreign taxes required to be withheld from such payments or benefits and
make any other required payroll deductions. Neither the Company nor any other member of the Company Group will pay the Executive’s taxes arising from or relating to any payments or benefits under the Agreement. 

(h) Counterparts. The Agreement may be executed electronically or in counterparts, each of which will be deemed an original, but all of
which together will constitute one and the same instrument. 
 [Signature page follows.] 

  
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 By its signature below, each of the parties signifies its acceptance of the terms of the
Agreement, in the case of the Company by its duly authorized officer. 
  

			
	THE COMPANY
		
	By:	 	 /s/ Frank Calderoni

		 	Name: Frank Calderoni
		 	Title: CEO
		 	Date: September 9, 2018

  

			
	THE EXECUTIVE
		
	By:	 	 /s/ David Morton

		 	 Name: David Morton
 Date: September 9,
2018EX-4.2

 Exhibit 4.2 

ARVINAS HOLDING COMPANY, INC. 
  

 

 
 REGISTRATION
RIGHTS AGREEMENT 
  
  

 
 This
Registration Rights Agreement (the “Agreement”) is entered into as of this      day of                     
2018, by and among Arvinas, Inc. (f/k/a Arvinas Holding Company, LLC), a Delaware corporation (the “Company”), the holders of the Company’s shares of Series A Preferred Stock (the “Series A Shares”), shares of
Series B Preferred Stock (the “Series B Shares”) and shares of Series C Preferred Stock (the “Series C Shares” and, together with the Series A Shares and the Series B Shares, the “Preferred Shares”)
listed on Exhibit A attached hereto (collectively, the “Investors”). 
 RECITAL 

WHEREAS, in connection with the conversion of the Company from a Delaware limited liability company to a Delaware corporation, the
Investors and the Company hereby agree that this Agreement shall govern the rights of the Investors to cause the Company to register shares of Common Stock issuable to the Investors. 

AGREEMENT 
 NOW,
THEREFORE, in consideration of the mutual agreements, covenants and conditions contained herein, the Company and the Investors agree as follows: 

SECTION 1. 

DEFINITIONS 
 For
purposes of this Agreement: 
 1.1 “Affiliate” means, as applied to the Company or any other specified person, any person
directly or indirectly controlling, controlled by or under direct or indirect common control with the Company or such other specified person, including, without limitation, any venture capital fund now or hereafter existing that is controlled by one
or more general partners or managing members of, or shares the same management company with, other equityholders, partners (including partners and affiliated partnerships managed by the same management company or managing (general) partner or by any
Person that is an Affiliate with such management company or managing (general) partner), members and a trust for the benefit of such other equityholders of such other specified person, and shall also include, in the case of a specified person who is
an individual, any Family Member of such person. 
 1.2 “Board” means the Board of Directors of the Company. 

1.3 “Common Stock” means shares of the Company’s common stock, par value $0.001 per share. 

 1.4 “Exchange Act” means the Securities Exchange Act of 1934, as amended, and
the rules and regulations promulgated thereunder. 
 1.5 “Excluded Registration” means (i) a registration relating to
the sale or grant of securities to employees of the Company or a subsidiary pursuant to a stock option, stock purchase, or similar plan; (ii) a registration relating to a Securities and Exchange Commission (or such other federal agency at the
time administering the Securities Act, the “Commission”) Rule 145 transaction; (iii) a registration on any form that does not include substantially the same information as would be required to be included in a registration statement
covering the sale of the Registrable Securities; or (iv) a registration in which the only shares of Common Stock being registered are shares of Common Stock issuable upon conversion of debt securities that are also being registered. 

1.6 “Family Member” means any parent, spouse, descendant (whether natural or adopted) or sibling of, or trust or other vehicle
formed solely for the benefit of and controlled by, such Person. 
 1.7 “Holder” (collectively, “Holders”)
means each Investor and any transferee, as permitted by Section 2.7 hereof, holding Registrable Securities, securities exercisable for or convertible into Registrable Securities or securities exercisable for securities convertible into
Registrable Securities. 
 1.8 “Person” means individuals, partnerships, corporations, trusts, limited liability companies
and other entities of whatever nature. 
 1.9 “Registration Expenses” means all expenses incurred in complying with
this Agreement, including, without limitation, all registration and filing fees, exchange listing fees, printing expenses, fees and disbursements of counsel for the Company and the reasonable fees and expenses of one (1) counsel selected by the
selling Holders holding at least a majority of the Registrable Securities to be registered to represent the selling Holders (the “Selling Stockholder Counsel”), state Blue Sky fees and expenses,
and the expense of any special audits or “cold comfort” letters incident to or required by any such registration, but excluding all underwriting discounts, selling commissions and stock transfer taxes applicable to the sale of Registrable
Securities, and fees and disbursements of counsel for any Holder, other than the fees and disbursements of the Selling Stockholder Counsel borne and paid by the Company as provided by this Agreement. 

1.10 “Registration Statement means a registration statement filed with the Commission for a public offering and sale of securities
(other than a registration statement on Form S-8 or Form S-4, or their successors). 

1.11 “Registrable Securities” means (i) the shares of Common Stock into which each Preferred Share held by any Investor
has been converted or is then convertible; (ii) any shares of Common Stock purchased or acquired by any Investor subsequent to the date hereof; and (iii) any other shares of Common Stock issued in respect of the shares described in clause
(i) or (ii) above because of stock splits, stock dividends, reclassifications, recapitalizations, 

  
 2 

 
reorganizations or other similar events; provided, however, that shares of Common Stock that are Registrable Securities shall cease to be Registrable Securities upon (x) any sale by
the Holders thereof pursuant to a Registration Statement or Rule 144 promulgated by the Commission under the Securities Act, (y) any sale in any manner to a person or entity which, by virtue of Section 2.7, is not entitled to the rights
provided by this Agreement or (z) termination of registration rights for such shares of Common Stock pursuant to Section 2.13. 

1.12 “Requesting Holders” means any Holder or Holders of at least twenty percent (20%) of the Registrable Securities. 

1.13 “Requisite Holders” means the Holders of at least 66 2/3% of the outstanding Registrable Securities. 

1.14 “SEC” means the Securities and Exchange Commission. 

1.15 “SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities Act. 

1.16 “SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act. 

1.17 “Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

SECTION 2. 

REGISTRATION RIGHTS 

The Company hereby grants to each of the Holders the registration rights set forth in this Section 2 with respect to the Registrable
Securities owned by such Holders. The Company and the Holders agree that the registration rights provided herein set forth the sole and entire agreement, and supersede any prior agreement, between the Company and the Holders with respect to
registration rights for the Company’s securities. 
 2.1. Demand Registration. 

(a) At any time after the 180 day period following the effective date of a Registration Statement filed in connection with the Company’s
initial public offering of its equity securities, the Requesting Holders may request, in writing, on up to two (2) separate occasions, that the Company effect a registration on Form S-1 (or any successor
form) of Registrable Securities owned by one or more Holders. If the Requesting Holders intend to distribute the Registrable Securities by means of an underwriting, they shall so advise the Company in their request. In the event such registration is
underwritten, the right of other Holders to participate in such registration shall be conditioned on such Holders’ participation in such underwriting. Upon receipt of any such request from the Requesting Holders, the Company shall promptly give
written notice of such proposed registration to all other Holders. Such other Holders shall have the right, by giving written notice to the Company within thirty (30) days after the Company provides its notice, to elect to have included in such
registration such of their 

  
 3 

 
Registrable Securities as such Holders may request in such notice of election. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an
underwriting agreement in customary form with an underwriter or underwriters that is mutually agreeable to the Company and the Holders holding a majority-in-interest of
the Registrable Securities that the Holders requested for inclusion in such registration. The Company shall, at its own expense and as expeditiously as possible, and in any event within ninety (90) days after the date such request is given by
the Requesting Holders, file a Form S-1 (or any successor form) for all Registrable Securities that the Company has been requested to so register. If the underwriter advises the Company or the Holders of
Registrable Securities requesting registration hereunder that, in its good faith view, marketing factors require a limitation of the number of Registrable Securities to be underwritten, then the Requesting Holders shall so advise all Holders of
Registrable Securities that otherwise would be underwritten pursuant hereto, and the number of Registrable Securities that may be included in the underwriting shall be allocated among such Holders of Registrable Securities, including the Requesting
Holders, in proportion (as nearly as practicable) to the number of Registrable Securities owned by each Holder or in such other proportion as shall mutually be agreed to by all such selling Holders; provided, however, that the number of Registrable
Securities held by the Holders to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting. For purposes of this Section 2.1(a), a registration shall not be counted as
“effected” if, as a result of an exercise of the underwriter’s cutback provisions this Section 2.1(a), fewer than fifty percent (50%) of Registrable Securities that the Requesting Holders have requested to be included in such
registration statement are actually included. 
 (b) At any time after the Company becomes eligible to file a Registration Statement on Form S-3 (or any successor form relating to secondary offerings, hereinafter, “Form S-3”), the Holders will have the right to require the Company to effect Registration
Statements on Form S-3 of Registrable Securities having a minimum gross proceeds in each registration on Form S-3 of at least $2,500,000. Upon receipt of any such
request, the Company shall promptly give written notice of such proposed registration to all other Holders. Such other Holders shall have the right, by giving written notice to the Company within thirty (30) days after the Company provides its
notice, to elect to have included in such registration such of their Registrable Securities as such Holders may request in such notice of election. Thereupon, the Company shall, as expeditiously as possible, and in any event within forty-five
(45) days after the date such initial request is given, file a Form S-3 for all Registrable Securities that the Company has been requested to so register. 

(c) Notwithstanding the foregoing obligations, if the Company furnishes to the Holders requesting a registration pursuant to this
Section 2.1 a certificate signed by the Company’s president stating that in the good faith judgment of the Board it would be materially detrimental to the Company and its stockholders for such registration statement to either become
effective or remain effective for as long as such registration statement would otherwise be required to remain effective, because such action would (i) materially interfere with a significant acquisition, corporate reorganization, or other
similar transaction involving the Company; (ii) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential; or (iii) render the Company unable to comply with
requirements under the Securities Act or Exchange Act, then the Company shall have the right to 

  
 4 

 
defer taking action with respect to such filing, and any time periods with respect to filing or effectiveness thereof shall be tolled correspondingly, for a period of not more than ninety
(90) days after the request of the Holders is given; provided, however, that the Company may not invoke this right more than once in any twelve (12) month period; and provided further that the Company shall not register any securities for
its own account or that of any other stockholder during such 90-day period other than an Excluded Registration. 

(d) The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to Subsection 2.1(a) (i)
during the period that is sixty (60) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is one hundred eighty (180) days after the effective date of, a Company-initiated registration,
provided that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; (ii) after the Company has effected [two] registrations pursuant to Subsection 2.1(a); or
(iii) if the Requesting Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Subsection 2.1(b). The Company
shall not be obligated to effect, or to take any action to effect, any registration pursuant to Subsection 2.1(b) (i) during the period that is thirty (30) days before the Company’s good faith estimate of the date of filing of, and
ending on a date that is ninety (90) days after the effective date of, a Company-initiated registration, provided that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to
become effective; or (ii) if the Company has effected [two] registrations pursuant to Subsection 2.1(b) within the twelve (12) month period immediately preceding the date of such request. A registration shall not be counted as
“effected” for purposes of this Subsection 2.1(d) until such time as the applicable registration statement has been declared effective by the SEC, unless the Requesting Holders withdraw their request for such registration, elect not to pay
the registration expenses therefor, and forfeit their right to one demand registration statement pursuant to Subsection 2.4, in which case such withdrawn registration statement shall be counted as “effected” for purposes of this Subsection
2.1(d); provided, that if such withdrawal is during a period the Company has deferred taking action pursuant to Subsection 2.1(c), then the Requesting Holders may withdraw their request for registration and such registration will not be counted as
“effected” for purposes of this Subsection 2.1(d). 
 2.2. Piggyback Registration. 

(a) Subject to Section 2.2(b), whenever the Company proposes to file a Registration Statement (other than an Excluded Registration) at any
time and from time to time, it will, prior to such filing, promptly give written notice to all Holders of its intention to do so and, if the Company receives the written request of any Holder holding Registrable Securities within twenty
(20) days after the Company provides such notice, the Company shall cause all Registrable Securities that the Company has been requested by such Holder or Holders to be registered under the Securities Act to the extent necessary to permit their
sale or other disposition; provided, however, that the rights set forth in this Section 2.2 shall not apply to Registration Statements to be filed pursuant to Section 2.1 hereof; and provided further that the Company shall have the right
to postpone or withdraw any registration effected pursuant to this Section 2.2 without obligation to any Holder. The expenses of such withdrawn registration shall be borne by the Company. 

  
 5 

 (b) In connection with any offering under this Section 2.2 involving an underwriting, the
Company shall not be required to include any Registrable Securities in such underwriting unless the holders thereof accept the terms of the underwriting as reasonably agreed upon between the Company and the underwriters selected by it. If the
underwriter advises the Company or the holders of Registrable Securities requesting registration hereunder that, in its good faith view, marketing factors require a limitation of the number of Registrable Securities to be underwritten, then the
Registrable Securities that are included in such offering shall be allocated among the selling holders in proportion (as nearly as practicable to) the number of Registrable Securities owned by each selling holder or in such other proportions as
shall mutually be agreed to by all such selling holders; provided that in no event shall (i) the number of Registrable Securities included in the offering be reduced unless all other securities (other than securities to be sold by the Company)
are first entirely excluded from the offering, or (ii) the amount of Registrable Securities included in the offering be reduced below twenty-five percent (25%) of the total amount of securities included in such offering unless such offering is
the initial public offering of the Company’s equity securities and no other Holder has included shares in such registration. For purposes of the provision in this Section 2.2(b) concerning apportionment, for any holder that is a
partnership, limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such holder, or the estates and Family Members of any such partners, retired partners, members, and
retired members and any trusts for the benefit of any of the foregoing persons, shall be deemed to be a single “holder”, and any pro rata reduction with respect to such holder shall be based upon the aggregate number of Registrable
Securities owned by all persons included in such “holder”. 
 2.3. Registration Procedures. If and whenever the Company is
required by the provisions of this Agreement to effect the registration of any of the Registrable Securities under the Securities Act, the Company shall: 

(a) Prepare and file with the Commission a Registration Statement with respect to such Registrable Securities and use its best efforts to cause
that Registration Statement to become and remain effective for a period of up to one hundred twenty (120) days or, if earlier, until the completion of the distribution; 

(b) Promptly prepare and file with the Commission any amendments and supplements to the Registration Statement and the prospectus included in
the Registration Statement as may be necessary to keep the Registration Statement effective, and comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such Registration Statement; 

(c) Promptly furnish to each selling Holder such reasonable numbers of copies of the Registration Statement, each amendment and supplement
thereto, prospectus, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as the selling Holder may reasonably request in order to facilitate the public sale or other disposition of
the Registrable Securities owned by the selling Holder; 

  
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 (d) Use commercially reasonable efforts to register or qualify the Registrable Securities covered
by the Registration Statement under the securities or Blue Sky laws of such states as the selling Holders shall reasonably request, and do any and all other acts and things that may be necessary or desirable to enable the selling Holders to
consummate the public sale or other disposition in such states of the Registrable Securities owned by the selling Holder; provided, however, that the Company shall not be required in connection with this Section 2.3(d) to qualify as a foreign
corporation or execute a general consent to service of process in any jurisdiction where it is not conducting business; 
 (e) In the event
of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also
enter into and perform its obligations under such an agreement; 
 (f) Promptly notify each selling Holder of Registrable Securities covered
by such Registration Statement, and each underwriter, if any, after it shall receive notice thereof, of the time when such Registration Statement has become effective or such supplement to any prospectus forming a part of such Registration Statement
has been filed; 
 (g) Promptly notify each selling Holder of Registrable Securities covered by such Registration Statement, and each
underwriter, if any, of any request by the Commission for the amending or supplementing of such Registration Statement or prospectus or for additional information; 

(h) Prepare and promptly file with the Commission, and promptly notify each selling Holder of Registrable Securities covered by such
Registration Statement, and each underwriter, if any, of such amendment or supplement to such Registration Statement or prospectus, as then in effect, as may be necessary to correct any statements or omissions if, at the time when a prospectus
relating to such securities is required to be delivered under the Securities Act, any event has occurred as the result of which any such prospectus or any other prospectus as then in effect would include an untrue statement of a material fact or
omit to state any material fact necessary to make the statements therein not misleading in light of the circumstances in which they were made; 

(i) Promptly notify each selling Holder of Registrable Securities covered by such Registration Statement, and each underwriter, if any, after
it shall receive notice or obtain knowledge thereof, of the issuance of any stop order by the Commission suspending the effectiveness of such Registration Statement or the initiation or threatening of any proceeding for that purpose and promptly use
all reasonable best efforts to prevent the issuance of any stop order or to obtain its withdrawal if such stop order should be issued; 
 (j)
At any time when a Registration Statement is effective under the Securities Act, promptly notify each selling Holder of Registrable Securities covered by such Registration Statement, and each underwriter, if any, of the happening of any event as a
result of which the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or

  
 7 

 
necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company shall promptly prepare a supplement or amendment to such prospectus so that it
will not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing; 

(k) Use commercially reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if
such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an
underwritten public offering, addressed to the underwriters, if any, and (ii) a letter dated as of such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent
certified public accountants to underwriters in an underwritten public offering addressed to the underwriters; 
 (l) If the Company has
delivered preliminary or final prospectuses to the selling Holders and after having done so the prospectus is amended to comply with the requirements of the Securities Act, the Company shall promptly notify the selling Holders and, if requested, the
selling Holders shall immediately cease making offers of Registrable Securities and return all prospectuses to the Company. The Company shall promptly provide the selling Holders with revised prospectuses and, following receipt of the revised
prospectuses, the selling Holders shall be free to resume making offers of the Registrable Securities; 
 (m) Cause all such Registrable
Securities to be listed on or included in each securities exchange or quotation system on which similar securities issued by the Company are then listed; 

(n) Provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for
all such Registrable Securities, in each case not later than the effective date of such registration; 
 (o) Promptly make available for
inspection by the selling Holders, any underwriter(s) participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all
financial and other records, pertinent corporate documents, and properties of the Company, and cause the Company’s officers, directors, employees, and independent accountants to supply all information reasonably requested by any such seller,
underwriter, attorney, accountant or agent, in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; and 

(p) Ensure that, at all times after any registration statement covering a public offering of securities of the Company under the Securities Act
shall have become effective, its insider trading policy shall provide that the Company’s directors may implement a trading program under Rule 10b5-1 of the Exchange Act. 

  
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 2.4. Allocation of Expenses. The Company will pay all Registration Expenses of all
registrations under this Agreement; provided, however, that if a registration under Section 2.1(a) is withdrawn at the request of the Holders requesting such registration (other than as a result of information concerning the business or
financial condition of the Company that is made known in writing to the Holders requesting registration after the date on which such registration was requested) and if the Requesting Holders elect not to have such registration counted as a
registration requested under Section 2.1(a), the Requesting Holders shall pay the Registration Expenses of such registration pro rata in accordance with the number of their Registrable Securities requested to be included in such registration.

 2.5. Indemnification and Contribution. 

(a) To the extent permitted by law, in the event of any registration of any of the Registrable Securities under the Securities Act pursuant to
this Agreement, the Company will indemnify and hold harmless each selling Holder (including each member, manager, partner, officer and director thereof and legal counsel and independent accountant thereto), each underwriter of such seller of such
Registrable Securities, and each other person, if any, who controls such seller or underwriter within the meaning of the Securities Act or the Exchange Act (each, a “Holder Indemnified Party”) against any expenses, losses, claims, damages
or liabilities, joint or several, to which such Holder Indemnified Party may become subject under the Securities Act, the Exchange Act, state securities or Blue Sky laws or otherwise, including any of the foregoing incurred in connection with the
settlement of any commenced or threatened litigation, insofar as such expenses, losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material
fact contained in (i) any Registration Statement under which such Registrable Securities were registered under the Securities Act, (ii) any preliminary prospectus or final prospectus contained in the Registration Statement or
(iii) any amendment or supplement to such Registration Statement, or arise out of or are based upon the omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not
misleading or any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities laws or
otherwise in connection with the offering covered by such Registration Statement; and the Company will reimburse such Holder Indemnified Party for any legal or any other expenses reasonably incurred by such Holder Indemnified Party in connection
with investigating or defending any such expense, loss, claim, damage, liability or action; provided, however, that the Company will not be liable to any Holder Indemnified Party in any such case to the extent that any such loss, claim, damage or
liability arises out of or is based upon any untrue statement or omission made in such Registration Statement, final prospectus, or any such amendment or supplement, in reasonable reliance upon and in conformity with information furnished (or not
furnished in the case of an omission or alleged omission) to the Company, in writing, by or on behalf of such Holder Indemnified Party specifically for use in the preparation thereof. 

  
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 (b) To the extent permitted by law, in the event of any registration of any of the Registrable
Securities under the Securities Act pursuant to this Agreement, each selling Holder, severally and not jointly, will indemnify and hold harmless the Company, each of the Company’s directors and officers who has signed the registration
statement, each underwriter, if any, each person, if any, who controls the Company or any such underwriter within the meaning of the Securities Act or the Exchange Act, any other seller of Registrable Securities or any such seller’s members,
managers, partners, officers and managers, and each person, if any, who controls such seller within the meaning of the Securities Act and the Exchange Act (each, a “Company Indemnified Party”; and together with the Holder Indemnified
Parties, the “Indemnified Parties”) against any expenses, losses, claims, damages or liabilities, joint or several, to which the Company Indemnified Party may become subject under the Securities Act, Exchange Act, state securities or Blue
Sky laws or otherwise, including any of the foregoing incurred in connection with the settlement of any commenced or threatened litigation, insofar as such expenses, losses, claims, damages or liabilities (or actions in respect thereof) (x)
arise out of or are based upon any untrue statement or alleged untrue statement of a material fact contained in (i) any Registration Statement under which such Registrable Securities were registered under the Securities Act, (ii) any
preliminary prospectus or final prospectus contained in the Registration Statement, or (iii) any amendment or supplement to the Registration Statement or (y) arise out of or are based upon any omission or alleged omission to state a
material fact required to be stated therein or necessary to make the statements therein not misleading, if and only if, in the case of any of clause (x) or (y), the statement or omission was made in reliance upon and in conformity with
information furnished in writing to the Company by or on behalf of such seller, specifically and expressly for use in connection with the preparation of such Registration Statement, prospectus, amendment or supplement (or not furnished in the case
of an omission or alleged omission); and each such seller of Registrable Securities, severally and not jointly, will reimburse the Company and each Indemnified Party for any legal or any other expenses reasonably incurred by the Company and each
such Indemnified Party entitled to indemnification in connection with investigating or defending any such loss, claim, damage, liability or action if the statement or omission was made in reliance upon and in conformity with information furnished in
writing to the Company by or on behalf of such seller, specifically for use in connection with the preparation of such Registration Statement, prospectus, amendment or supplement (or not furnished in the case of an omission or alleged omission);
provided, however, that the obligations of each such Holder hereunder shall be limited to an amount equal to the net proceeds received by such Holder in connection with such offering of such Registrable Securities, except in the case of fraud or
willful misconduct by such Holder; provided, further, however, that no such Holder will be liable for any amount paid in settlement of any such claim, loss, damage, liability or action if such settlement is effected without the consent of such
Holder, which consent shall not be unreasonably withheld, conditioned or delayed. 
 (c) Each Indemnified Party entitled to indemnification
under this Section 2.5 shall give notice to the party required to provide indemnification (the “Indemnifying Party”) promptly after such Indemnified Party has knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom; provided, however, that counsel for the Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be approved by
the Indemnified Party, whose approval shall not be unreasonably withheld, conditioned or delayed; provided, further, that the failure of any Indemnified Party to give notice as provided herein shall not

  
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relieve the Indemnifying Party of its obligations under this Agreement, except to the extent that the Indemnifying Party’s ability to defend against such claim or litigation is materially
impaired as a result of such failure to give notice; and provided, further, that prior to assuming control of such defense, the Indemnifying Party must (i) acknowledge that, if the facts as alleged by the claimant in such claim are true, it
would have an indemnity obligation for the expenses, losses, claims, damages and liabilities resulting from such claim as provided hereunder and (ii) must furnish the Indemnified Party with reasonable evidence that the indemnifying party has
adequate resources to defend such claim and fulfill its indemnity obligations hereunder. The Indemnifying Party shall not be entitled to assume or maintain control of the defense of any claim and shall pay the fees and expenses of one counsel
retained by the Indemnified Party if (A) the Indemnifying Party does not deliver the acknowledgment referred to in clause (i) above within thirty (30) days of receipt of notice of the claim, (B) the claim relates to or arises in
connection with any criminal proceeding, action, indictment or allegation, (C) the Indemnified Party reasonably believes an adverse determination with respect to the claim would be detrimental to the reputation or future business prospects of
the Indemnified Party or any of its Affiliates, (D) the claim seeks an injunction or equitable relief against the Indemnified Party or any of its Affiliates or (E) the Indemnifying Party has failed or is failing to prosecute or defend
vigorously the claim. The Indemnified Party may participate in such defense at such party’s expense; provided, however, that the Indemnifying Party shall pay such expense if representation of such Indemnified Party by the counsel retained by
the Indemnifying Party would be inappropriate due to actual or potential conflicts of interests between the Indemnified Party and any other party represented by such counsel in such proceeding. No Indemnifying Party in the defense of any such claim
or litigation shall, except with the consent of each Indemnified Party, consent to entry of any judgment or enter into any settlement that does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified
Party of a release from all liability in respect of such claim or litigation, and no Indemnified Party shall consent to entry of any judgment or settle such claim or litigation without the prior written consent of the Indemnifying Party. Each
Indemnified Party shall furnish such information regarding itself or the claim in question as an Indemnifying Party may reasonably request in writing and as shall be reasonably required in connection with the defense of such claim and litigation
resulting therefrom. 
 (d) In order to provide for just and equitable contribution in circumstances in which the indemnification provided
for in this Section 2.5 is due in accordance with its terms but for any reason is held to be unavailable to an Indemnified Party in respect to any expenses, losses, claims, damages and liabilities referred to herein, then the Indemnifying Party
shall, in lieu of indemnifying such Indemnified Party, contribute to the amount paid or payable by such Indemnified Party as a result of such expenses, losses, claims, damages or liabilities to which such party may be subject in proportion as is
appropriate to reflect the relative fault of the Indemnifying Party on the one hand and the Indemnified Party on the other in connection with the statements or omissions that resulted in such expenses, losses, claims, damages or liabilities, as well
as any other relevant equitable considerations. The relative fault of the Indemnifying Party and the Indemnified Party shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of material fact related
to information supplied by the Indemnifying Party or the Indemnified Party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Holders agree
that it would not be just and equitable if contribution pursuant to 

  
 11 

 
this Section 2.5 were determined by pro rata allocation or by any other method of allocation that does not take account of the equitable considerations referred to above. Notwithstanding the
provisions of this Section 2.5(d), (i) in no case shall any one Holder be liable or responsible for any amount in excess of the net proceeds received by such Holder from the offering of Registrable Securities and (ii) the Company shall be
liable and responsible for any amount in excess of such proceeds; provided, however, that no person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution for any
person who was not guilty of such fraudulent misrepresentation. Any party entitled to contribution will, promptly after receipt of notice of commencement of any action, suit or proceeding against such party or parties under this Section, notify such
party or parties from whom such contribution may be sought, but the omission so to notify such party or parties from contribution may be sought shall not relieve such party from any other obligation it or they may have thereunder or otherwise under
this Section. No party shall be liable for contribution with respect to any action, suit, proceeding or claim settled without its prior written consent, which consent shall not be unreasonably withheld. 

(e) The obligations of the Company and the Holders under this Section 2.5 shall survive completion of any offering of Registrable
Securities in any Registration Statement and the termination of this Agreement.  

2.6. Rule 144 Requirements. After the earliest of (x) the closing of the sale of securities of the Company pursuant to a
Registration Statement, (y) the registration by the Company of a class of securities under Section 12 of the Exchange Act or (z) the issuance by the Company of an offering circular pursuant to Regulation A under the Securities Act,
and with a view to making available to the Holders the benefits of SEC Rule 144 and any other rule or regulation of the SEC that may at any time permit an Holder to sell securities of the Company to the public without registration or pursuant to a
registration on Form S-3, the Company agrees to: 
 (a) comply with the requirements of Rule 144
under the Securities Act with respect to making and keeping available current public information about the Company; 
 (b) use its best
efforts to file with the Commission in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements); and 

(c) furnish to any holder of Registrable Securities promptly after receipt of a written request (i) a written statement by the Company as
to its compliance with the requirements of said Rule 144, and the reporting requirements of the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose
securities may be resold pursuant to Form S-3 (at any time after the Company so qualifies), (ii) a copy of the most recent annual or quarterly report of the Company and (iii) such other information,
reports and documents of the Company as such holder may reasonably request to avail itself of any similar rule or regulation of the Commission allowing it to sell any such securities without registration including, without limitation, Rules 144 and
144A, or pursuant to Form S-3 (at any time after the Company so qualifies to use such form). 

  
 12 

 2.7. Assignment of Registration Rights. The rights of an Investor under this Agreement may
only be transferred to a transferee or assignee of the Registrable Securities provided that such Investor shall, within ten (10) business days after such transfer, furnish to the Company written notice of the name and address of such transferee
or assignee and the number of Registrable Securities with respect to which such rights are being assigned. Any transferee of an Investor’s Registrable Securities shall, as a condition to such transfer, deliver to the Company a written
instrument by which such transferee agrees to be bound by the obligations imposed upon the Investors under this Agreement to the same extent as if such transferee were an Investor hereunder. The transferee or assignee of an Investor’s rights
and obligations hereunder shall be deemed a “Investor” for purposes of this Agreement. 
 2.8. Limitations on Subsequent
Registration Rights. The Company shall not, without the prior written consent of the Requisite Holders, enter into any agreement with any holder or prospective holder of any securities of the Company that would allow such holder or prospective
holder to (a) include securities of the Company in any registration filed under Section 2.1 or Section 2.2, (b) make a demand registration that could result in such registration statement being declared effective prior to twelve
(12) months after the initial underwritten public offering of the Common Stock or (c) have registration rights that are pari passu with or superior to the rights granted to the Holders under this Agreement. 

2.9. Indemnification with Respect to Underwritten Offering. In the event that Registrable Securities are sold pursuant to a Registration
Statement in an underwritten offering pursuant to Section 2.1, the Company agrees to enter into an underwriting agreement containing customary representations and warranties with respect to the business and operations of an issuer of the
securities being registered and customary covenants and agreements to be performed by such issuer, including without limitation customary provisions with respect to indemnification by the Company of the underwriters of such offering. 

2.10. Information by Holder. As a condition to be included in any registration statement, each holder of Registrable Securities included
in any registration shall furnish to the Company such information regarding such holder and the distribution proposed by such holder as the Company may reasonably request in writing and as shall be required in connection with any registration,
qualification or compliance referred to in this Agreement, within ten (10) days of such request. 
 2.11. Selection of
Underwriter. The Company shall have the right to designate the managing underwriter in any underwritten offering, except for any registration effected pursuant to Section 2.1, which designation shall be subject to the approval of the
Holders holding at least a majority of the Registrable Securities that all Holders requested to be included in such offering, and which approval shall not be unreasonably withheld. 

2.12. Mergers, Etc. The Company shall not, directly or indirectly, enter into any merger, consolidation, or reorganization in which the
Company shall not be the surviving entity unless the proposed surviving entity shall, prior to such merger, consolidation, or reorganization, agree in writing to assume the obligations of the Company under this Agreement, and for that purpose
references hereunder to “Registrable Securities” shall be deemed to be references to the 

  
 13 

 
securities that the Holder would be entitled to receive in exchange for Registrable Securities under the terms of any such merger, consolidation, or reorganization; provided, however, that the
provisions of this Agreement shall not apply in the event of any merger, consolidation, or reorganization in which the Company is not the surviving entity if all Holders are entitled to receive in exchange for their Registrable Securities
consideration consisting solely of (a) cash, (b) securities of the acquiring corporation that may be immediately sold to the public without registration under the Securities Act or (c) securities of the acquiring entity that the acquiring
entity has agreed to register within 90 days of completion of the transaction for resale to the public pursuant to the Securities Act. 

2.13. Termination. The rights and obligations set forth in this Agreement with respect to any Holder shall terminate on the earlier to
occur of: (a) such time after consummation of the initial public offering of the Company’s equity securities as Rule 144 or another similar exemption under the Securities Act is available for the sale of all of such Holder’s shares
without limitation during a three-month period without registration and (b) the fifth (5th) anniversary of the consummation of the initial public offering of the Company’s equity securities. 

SECTION 3. 

MISCELLANEOUS 
 3.1.
Notices. Except as expressly set forth to the contrary in this Agreement, all notices, requests, or consents required or permitted to be given under this Agreement must be in writing and shall be deemed to have been given (a) three (3)
days after the date mailed by registered or certified mail, addressed to the recipient, with return receipt requested or for Holders whose principal place of business is outside the United States, one (1) business day after deposit with an
internationally recognized overnight courier, specifying next day delivery, with written verification of receipt, (b) upon delivery to the recipient in person or by courier, or (c) upon receipt of a facsimile or electronic mail
transmission by the recipient. Such notices, requests and consents shall be given (i) to Holders at their addresses, fax numbers or electronic mail addresses on Schedule A attached hereto, or such other address, fax number or electronic mail
address as a Holder may specify by notice to the Company and to all of the other Holders, or (ii) to the Company at: 5 Science Park, 395 Winchester Avenue, New Haven, CT 06511, or such other address or fax numbers as the Company may specify by
notice to the Holders. Whenever any notice is required to be given by law or this Agreement, a written waiver thereof, signed by the person entitled to notice, whether before or after the time stated therein, shall be deemed equivalent to the giving
of such notice. 
 3.2. Entire Agreement. This Agreement constitutes the entire agreement of the Company and the Investors relating to
the subject matter of this Agreement and supersedes all prior contracts or agreements with respect to the subject matter of this Agreement, whether oral or written. There are no representations, agreements, arrangements, or understandings, oral or
written, between or among the parties hereto relating to the subject matter of this Agreement which are not fully expressed herein. 

  
 14 

 3.3. Consent to Jurisdiction. The parties to this Agreement hereby consent to the
exclusive jurisdiction of the federal and state courts of the State of Delaware in connection with any matter or dispute arising under this Agreement or between them regarding the affairs of the Company and waive any objection they may have to such
jurisdiction or to the venue of any such matter or dispute and any claim that such matter or dispute has been brought in an inconvenient forum. Effective service of process may be made upon any Investor pursuant to the notice provisions of
Section 3.1. To the fullest extent permitted by law, and as separately bargained- for-consideration, each party hereby waives any right to trial by jury in any action, suit, proceeding or counterclaim of
any kind arising out of or relating to this Agreement. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT MATTER
OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND
THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL
RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 
 3.4. Amendment or Modification. Any term of this Agreement may be amended or
modified and the observance of any term of this Agreement may be waived (either generally or in a particular instance and either retroactively or prospectively), at any time and from time to time, by a written instrument signed by the Company and
the Requisite Holders; provided that (a) any provision hereof may be waived by any waiving party on such party’s own behalf, without the consent of any other party and (b) this Agreement may not be amended, modified or terminated and
the observance of any term hereunder may not be waived with respect to any Holder without the written consent of such Holder unless such amendment, modification, termination or waiver applies to all such Holders in the same fashion. Any amendment or
waiver effected in accordance with this Section 3.4 shall be binding upon the Company and each of the Holders and their respective successors and assigns. 

3.5. Binding Effect. Subject to the restrictions on Transfers set forth in this Agreement, this Agreement is binding on and inures to
the benefit of the parties and their respective heirs, legal representatives, successors and permitted assigns. 
 3.6. Governing Law;
Severability. This Agreement is governed by and shall be construed in accordance with the law of the State of Delaware, exclusive of its conflict-of-laws principles.
If any provision of this Agreement or the application thereof to any person or circumstance is held invalid or unenforceable to any extent, the remainder of this Agreement and the application of that provision shall be enforced to the fullest extent
permitted by law. 
 3.7. Further Assurances. In connection with this Agreement and the transactions contemplated hereby, each
Investor shall execute and deliver any additional documents and instruments and perform any additional acts that may be necessary or appropriate to effectuate and perform the provisions of this Agreement and those transactions, as requested by the
Board. 

  
 15 

 3.8. Interpretation. Titles or captions of Articles and Sections contained in this
Agreement are inserted as a matter of convenience and for reference, and in no way define, limit, extend or describe the scope of this Agreement or the intent of any provision hereof. The terms of this Agreement have been negotiated by the parties
hereto and the language used in this Agreement shall be deemed to be the language chosen by the parties hereto to express their mutual intent. This Agreement shall be construed without regard to any presumption or rule requiring construction against
the party causing such instrument or any portion thereof to be drafted, or in favor of the party receiving a particular benefit under this Agreement. No rule or strict construction will be applied against any party hereto. In this Agreement, unless
a clear intention appears otherwise: (a) the singular number includes the plural number and vice versa; (b) reference to any person includes such person’s successors and assigns but, if applicable, only if such successors and assigns
are not prohibited by this Agreement, and reference to a person in a particular capacity excludes such person in any other capacity or individually; (c) reference to any gender includes each other gender; (d) reference to any agreement,
document or instrument means such agreement, document or instrument as amended or modified and in effect from time to time in accordance with the terms thereof; (e) reference to any law means such law as amended, modified, codified, replaced or
reenacted, in whole or in part, and in effect from time to time, including rules and regulations promulgated thereunder; (f) “hereunder,” “hereof,” “hereto,” and words of similar import shall be deemed references to
this Agreement as a whole and not to any particular section or other provision hereof; (g) “including” (and with correlative meaning “include”) means including without limiting the generality of any description preceding such
term; (h) “or” is used in the inclusive sense of “and/or”; (i) with respect to the determination of any period of time, “from” means “from and including” and “to” means “to but excluding”;
(j) references to documents, instruments or agreements shall be deemed to refer as well to all addenda, schedules or amendments thereto; and (k) section references shall be deemed to refer to all subsections thereof, unless otherwise expressly
indicated. 
 3.9. Counterparts. This Agreement may be executed in any number of counterparts with the same effect as if all parties
had signed the same document, and all counterparts shall be construed together and shall constitute the same instrument. This Agreement may be executed by facsimile or other electronic signatures. 

3.10. General Interpretation. The terms of this Agreement have been negotiated by the parties hereto and the language used in this
Agreement shall be deemed to be the language chosen by the parties hereto to express their mutual intent. This Agreement shall be construed without regard to any presumption or rule requiring construction against the party causing such instrument or
any portion thereof to be drafted, or in favor of the party receiving a particular benefit under this Agreement. No rule of strict construction will be applied against any person. 

[The next page is the signature page.] 

  
 16 

 IN WITNESS WHEREOF, this Registration Rights Agreement has been duly executed and delivered by
the parties as of the date first above written. 
  

							
	THE COMPANY:	 		 	ARVINAS HOLDING COMPANY, INC.
				
		 		 	By:	 	  

		 		 	Name:	 	John Houston
		 		 	Title:	 	President and CEO

 [Additional Signature Page Follows] 

[Signature Page to Registration Rights Agreement] 

 INVESTORS:
  

			
	5AM VENTURES III, L.P.
	
	By: 5AM Partners III LLC, its General Partner
		
	By:	 	
                     
                            

	Name:	 	Andrew J. Schwab
	Title:	 	Managing Member
	
	5AM CO-INVESTORS III, L.P.
	
	By: 5AM Partners III LLC, its General Partner
		
	By:	 	  

	Name:	 	Andrew J. Schwab
	Title:	 	Managing Member

 [Signature Page to Registration Rights Agreement] 

 
			
	CANAAN IX L.P.
	
	 BY:  CANAAN PARTNERS IX LLC

       Its General Partner

		
	By:	 	
                     
                    

	Name:	 	Guy Russo
	Title:	 	Member

  
 3 

 
			
	RA CAPITAL HEALTHCARE FUND, L.P.
		
	By:	 	RA Capital Management, LLC
	Its:	 	General Partner
		
	By:	 	
                     
                       

		 	Name: Amanda Daniels
		 	Title:   Authorized Signatory

  
 4 

 
					
	BLACKWELL PARTNERS LLC – SERIES A
		
	By:	 	
                     
                        

		 	Name:	 	Abayomi A. Adigun
		 	Title:	 	Investment Manager
		 		 	DUMAC, Inc.
		 		 	Authorized Agent
		
	By:	 	
                     
                                

		 	Name:	 	Janine M. Lall                                
		 	Title:	 	Controller
		 		 	DUMAC, Inc.
		 		 	Authorized Agent

  
 5 

 
			
	NEW LEAF VENTURES III, L.P.
		
	By:	 	New Leaf Venture Associates III, L.P., its General Partner
		
		 	 By: New Leaf Venture Management III, L.L.C., its General Partner

		
	By:	 	
                     
        

	Name:	 	Liam T. Ratcliffe
	Title:	 	Managing Partner

  
 6 

 
			
	Nextech V GP S.à r.l. on behalf of
	NEXTECH V ONCOLOGY S.C.S., SICAV-SIF
		
	By:	 	
                     
    

	Name:	 	James Pledger
	Title:	 	Manager
		
	By:	 	  

	Name:	 	James Vella Bamber
	Title:	 	Manager

  
 7 

 
			
	ORBIMED PRIVATE INVESTMENTS VI, LP
		
	By:	 	OrbiMed Capital GP VI LLC,
		 	its General Partner
		
	By:	 	OrbiMed Advisors LLC,
		 	its Managing Member
		
	By:	 	
                     
                    

		 	Name: Carl Gordon
		 	Title:   Member

  
 8 

 
			
	CONNECTICUT INNOVATIONS, INCORPORATED
		
	By:	 	
                     
                            

	Name:	 	
	Title:	 	

  
 9 

 
			
	DEERFIELD SPECIAL SITUATIONS FUND, L.P.
		
	By:	 	Deerfield Mgmt, L.P., its General Partner
		
	By:	 	J.E. Flynn Capital, LLC, its General Partner
		
	By:	 	
                     
                                    

	Name:	 	David J. Clark
	Title:	 	Authorized Signatory
	
	DEERFIELD PRIVATE DESIGN FUND III, L.P.
		
	By:	 	Deerfield Mgmt III, L.P., its General Partner
		
	By:	 	J.E. Flynn Capital III, LLC, its General Partner
		
	By:	 	  

	Name:	 	David J. Clark
	Title:	 	Authorized Signatory
	
	DEERFIELD PRIVATE DESIGN FUND IV, L.P.
		
	By:	 	Deerfield Mgmt IV, L.P., its General Partner
		
	By:	 	J.E. Flynn Capital IV, LLC, its General Partner
		
	By:	 	  

	Name:	 	David J. Clark
	Title:	 	Authorized Signatory

  
 10 

 
			
	ELM STREET VENTURES, LP
		
	By:	 	Elm. Street Venture Associates, LLC, its General Partner
		
	By:	 	
                     
                    

	Name:	 	Robert Bettigole
	Title:	 	Managing Partner

  
 11 

 
			
	JASMINE LANE VENTURES, LLC
		
	By:	 	
                     
                    

	Name:	 	Erin Stephen
	Title:	 	Manager

  
 12 

 
			
	HH ARV HOLDINGS, LLC
		
	By:	 	
                     
                    

		 	Name: Colm O’Connell
		 	Title:   Director

  
 13 

 
			
	PRECISION ONCO LIMITED
		
	By:	 	
                     
                            

		 	Name: Yuan Sun
		 	Title:   Director

  
 14 

 
			
	KEVIN L. RAKIN IRREVOCABLE TRUST
		
	By:	 	
                     
                

		 	Name: Lloyd Hoffman
		 	Title:   Trustee

  
 15 

 
	
	
                     
                                         
   

	KEVIN L. RAKIN

  
 16 

 
	
	
                     
                                         
   

	DR. CRAIG CREWS

  
 17 

 
			
	BRADLEY A. MARGUS REVOCABLE TRUST
		
	By:	 	
                     
            

	Name:	 	Brad Margus
	Title:	 	Trustee

  
 18 

 
	
	
                     
                                         
   

	DR. JOHN HOUSTON

  
 19 

 
	
	
                     
                                         
   

	SEAN CASSIDY

  
 20 

 
	
	
                     
                                         
   

	DR. MANUEL LITCHMAN

  
 21 

 EXHIBIT A 

Schedule of Investors 
  

	
	 Investor Name and Address

	
	 5AM Co-Investors III, L.P.

	
	 5AM Ventures III, L.P.

	
	 Blackwell Partners LLC – Series A

	
	 Canaan IX L.P.

	
	 Sean Cassidy

	
	 Connecticut Innovations, Incorporated

	
	 Craig Crews

	
	 Deerfield Private Design Fund III, L.P.

	
	 Deerfield Private Design Fund IV,
L.P.

	
	 Investor Name and Address

	
	 Deerfield Special Situations Fund, L.P.

	
	 Elm Street Ventures, LP

	
	 HH ARV Holdings, LLC

	
	 John Houston

	
	 Jasmine Lane Ventures, LLC

	
	 Dr. Manuel Litchman

	
	 Bradley A. Margus Revocable Trust

	
	 New Leaf Ventures III, L.P.

	
	 Nextech V Oncology S.C.S., SICAV-SIF

	
	 Orbimed Private Investments VI, LP

	
	 Precision Onco Limited

	
	 Investor Name and Address

	
	 RA Capital Healthcare Fund, L.P.

	
	 Kevin L. Rakin Irrevocable Trust

	
	 Kevin L. Rakin

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