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                                                                    Exhibit 10.7

[LOGO] Opian Pharmaceuticals, Inc.

Dear Dr. Farrar:

On behalf of Opian Pharmaceuticals, Inc. (the "Company"), I would like to offer
you a position as President and CEO of the Company. The purpose of this letter
is to summarize the terms of your employment with the Company, should you accept
our offer.

As of October, 17, 1994, you will commence employment with the Company. You will
report directly to the J.J.C. - Board of Directors of the Company.
Contemporaneously with the term of your employment, you will be offered a seat
on the Board. Your initial salary will be $175,000 per annum. Such salary shall
be paid in conformance with the Company's customary practice as established or
modified from time to time.

You will receive a bonus of $25,000 upon completion of a second round of
financing of the Company of at least $1,000,000, anticipated to occur within six
months time.

In addition to the closing bonus referenced above, you will be eligible for an
annual performance bonus based on the Company's attainment of goals or
objectives that are to be established by the Board of Directors of the Company.
The Board will seek your active participation in the establishment of these
goals.

Contemporaneously with your acceptance of this offer, you will have the
opportunity to purchase 2,266,400 shares of common stock of the Company for an
aggregate purchase price of $1150. You will be required to sign stock purchase
documents with the Company, which will provide certain future investors in the
Company and the Company with customary rights of first refusal and cosale with
respect to your shares, and will include a customary lock-up agreement in the
event of public offerings, and if as we anticipate, the Company with your
assistance succeeds in i) raising at least $1.5 million in capital in exchange
for Preferred Stock convertible into not more than 6 million shares of Common
Stock on terms acceptable to the Board, ii) hiring the additional management
personnel we have discussed who receive the equivalent of not more than 566,600
shares of Common Stock and iii) entering into the technology transfer agreements
and consulting agreements we have discussed, all as approved by the Board, in
exchange for the equivalent of an additional not more than 2 million shares of
Common Stock, your shares will constitute 20% of the Company's total common-
equivalent shares. If for any reason, the Company has not achieved these goals
by the first anniversary of your acceptance of this offer, the stock purchase
documents will allow the Company to repurchase from you, at your cost, an amount
of your shares sufficient to reduce your ownership of the Company's stock to 20%
on a fully diluted basis. In addition, your shares will be subject to vesting
monthly at the rate of 25% per annum, provided that if the Company consummates a
transaction in which the Company receives $10,000,000 or more (which amount may
be consideration for equity or research funding) within three years from your
date of hire, 25% of all your remaining unvested shares will immediately vest.
In addition, all of your shares will fully vest in the event the Company is
sold.
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You have expressed a concern that efforts be made to maintain your equity
position in the Company at a minimum of 5% in the event the Company attracts
additional rounds of institutional financing in the future. Accordingly, the
Company will use all reasonable good faith efforts to give you the opportunity
to maintain a 5% level of ownership during your employment with the company,
whether through participation in future equity financings, or otherwise. This
commitment, however, is subject to the approval of future investors.

You will also be entitled to participate in the Company's medical insurance plan
(such medical plan to be equal or superior to the benefits package outlined in
Exhibit A hereto). In addition, the Company will pay the premium on a $1,300,000
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life insurance policy on your behalf.

Lastly, as a condition of employment with Opian, you will be required to sign a
standard Employee Noncompetition, Confidentiality and Inventions Agreement in a
form which is mutually acceptable.

The above employment terms in this agreement are not contractual. They are a
summary of our initial at-will employment relationship and, as such, are subject
to later modification as business interests warrant. The Company believes that
such an "at-will" relationship is in the best interest of both the Company and
its employees.

This offer of employment expires on October 14, 1994.

It would be a great pleasure to welcome you to Opian Pharmaceuticals, Inc. I
anticipate that you will be able to make a key contribution to the Company's
success.

If the foregoing terms are acceptable, please sign and return the enclosed copy
of this letter to the undersigned.

                                 Very Truly yours,

                                 OPIAN PHARMACEUTICALS, INC.

                                 /s/ Robert Nelsen
                                 ----------------------------------
                                 Robert Nelsen, President

Accepted and Agreed

/s/ John J. Farrar
--------------------------------
Dr. John Farrar

Date: October 9 , 1994
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Enclosure<PAGE>

                                                                    EXHIBIT 10.8

January 6, 1995

Dear Dr. Maycock:

On behalf of Adolor Corporation (the "Company"), I would like to offer you a
position as Vice President of Exploratory Research and Drug Discovery of the
Company. The purpose of this letter is to summarize the terms of your employment
with the Company should you accept the offer.

As of January 16, 1995, you will commence employment with the Company. You will
report directly to the President of the Company. Your initial salary will be
$125,000 per year. Such salary shall be paid in conformance with the Company's
customary practice as established or modified from time to time. Currently, the
Company is issuing salary every other Friday.

You will be eligible for an annual performance bonus based on the Company's
attainment of goals or objectives that are to be established by the Board of
Directors of the Company. The Board will seek your active participation in the
establishment of these goals.

Contemporaneously with your acceptance of this offer, you will have the
opportunity to participate in a Company stock option plan. The Company has
adopted a 1995 Equity Compensation Plan (the "Plan"), which has been approved by
holders of a majority of the Company's outstanding common stock, par value
$0.0001 (the "Common Stock"). You will be offered stock options for 350,000
shares of the Common Stock which will vest over the next 4 years at a monthly
rate of 2.083% of the total. The price of each share covered by the option shall
be $0.025, which is the fair market value on the date of the grant as specified
in the Plan.

You will also be entitled to participate in the Company's medical insurance
plan. If you choose not to participate in the medical insurance plan, the
monetary contribution ("Benefit Stipend") that the Company would have
contributed to that medical insurance plan on your behalf will be made available
to you to pay the costs for continuing your current life insurance policy. If
there is, as expected, excess Benefit Stipend after paying the costs of the life
insurance policy, then that excess shall be placed in reserve to assist you in
paying your share of the costs of the medical insurance plan should you choose
to participate in that plan in the future. If you do not
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choose to participate in the medical insurance plan in the future, you will
forfeit any claim to that reserve.

You will also be entitled to a $15,000 one time severence payment if the
termination of your employment occurs at a time when there is at least six
months of "burn rate" in the Company's accounts.

Lastly, as a condition of employment with the Company, you will be required to
sign a standard Employee Noncompetition, Confidentiality and Inventions
Agreement in a form which is mutually acceptable.

The above employment terms in this agreement are not contractual. They are a
summary of our initial at-will employment relationship and, as such, are subject
to later modification as business interests warrant.

The offer of employment expires on January 13, 1995.

It would be a great pleasure to welcome you to Adolor Corporation. I am sure you
will contribute greatly to the Company's success.

If the foregoing terms are acceptable, please sign, date and return the enclosed
copy of this letter to me.

                                   Very truly yours,

                                   Adolor Corporation

                                   /s/ John J. Farrar
                                   _____________________________
                                   John Farrar, President

Accepted and Agreed

/s/ Alan L. Maycock
______________________
Alan Maycock

Date:  January 6, 1995.

                                      -2-<PAGE>

                                                                    Exhibit 10.9

April 23, 1997

Mr. Peter J. Schied
60 Sunshine Drive
Southampton, PA 18966

Dear Mr. Schied:

On behalf of Adolor Corporation (the "Company"), I would like to offer you a
position as Vice President and Chief Financial Officer at the Company. Your
responsibilities will include, among other things, all financial and
administrative matters of the Company. The purpose of this letter is to
summarize the terms of your employment with the Company should you accept the
offer.

You will commence employment with the Company on Monday, May 26, 1997 and you
will report directly to John Farrar, President and CEO. Your base salary will be
$138,000 per year. Such salary shall be paid in conformance with the Company's
customary practice as established or modified from time to time. Currently, the
Company is paying salary on alternate Fridays.

Contemporaneously with your acceptance of this offer, you will be granted an
option to purchase 500,000 shares of the Company's Common Stock, which will vest
in equal monthly amounts over the next 4 years. The exercise price of each share
covered by the option shall be $0.07, which is the fair market value on the date
of the grant. The options will be Incentive Stock Options and will be issued
pursuant to the Company's Stock Option Plan, a copy of which is attached.

You will be entitled to three weeks of vacation annually, and you will be
entitled to participate in the Company's benefit plans. In addition, the Company
will provide you with term life insurance equal to two times your annual base
salary. You will be eligible to participate in the Company's bonus program which
is a discretionary program.

If you are terminated pursuant to a change in control or for any other reason
than for just cause, then the Company, or its successor, shall be obligated to
continue to pay you at your then current base salary rate for a period of six
months following such termination. The Company may defer such severance payments
during such periods as it has less than six months of then current burn rate" in
its accounts including accounts receivable.
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Lastly, as a condition of employment with the Company, you will be required to
sign a standard Employee Noncompetition, Nondisclosure and Development
Agreement, a copy of which is attached, hereto.

The above employment terms in this agreement are not contractual. They are a
summary of our initial at-will employment relationship and, as such, are subject
to later modification as business conditions warrant; provided, however, that
the terms of the severance payments may not be modified without your consent.

This offer of employment expires at 5:00 p.m. on Friday, May 2, 1997.

I hope you accept this offer. It will be a great pleasure to welcome you to
Adolor Corporation, and I am sure you will contribute greatly to the Company's
success.

If the foregoing terms are acceptable, and you wish to accept this offer
pursuant to such terms, please sign, date and return the enclosed copy of this
letter to me.

                                 Very truly yours,

                                 Adolor Corporation

                                 /s/ John J. Farrar
                                 ______________________________________
                                 John J. Farrar, President and CEO

Accepted and Agreed

/s/ Peter Schied
________________________

Date:

                                      -2-
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                                  May 7, 1997

Mr. Peter J. Schied
60 Sunshine Drive
Southampton, PA 18966

Dear Peter:

This letter will amend my letter to you dated April 23, 1997 as follows:

     a)  Your start date will be June 1, 1997;

     b)  The expiration of the offer period is extended to 5:00 p.m. on May 8,
         1997.

                                        Very truly yours,

                                        /s/ John J. Farrar
                                        _________________________
                                        John J. Farrar
                                        President and CEO

JJF/

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