Document:

EXHIBIT 10.2

                             AMENDMENT NO. 1 TO THE
                          AGREEMENT AND PLAN OF MERGER
                                  BY AND AMONG
                             ENHANCE BIOTECH, INC.,
                            ARDENT ACQUISITION CORP.
                                       AND
                          ARDENT PHARMACEUTICALS, INC.

      This  Amendment  No. 1  ("Amendment")  to the Agreement and Plan of Merger
(the "Agreement") made and entered into as of the 20th day of November, 2004, by
and among  ENHANCE  BIOTECH,  INC., a Delaware  Corporation  ("Parent"),  ARDENT
ACQUISITION  CORP., a North Carolina  corporation and wholly owned subsidiary of
Parent  ("Merger  Sub"),  and ARDENT  PHARMACEUTICALS,  INC.,  a North  Carolina
corporation (the "Company").

                              W I T N E S S E T H:

      WHEREAS,  capitalized  terms used but not  defined  herein  shall have the
meaning ascribed to such terms in the Agreement.

      WHEREAS,  each of Parent,  Merger Sub and the Company  desire to amend the
Agreement  to (i)  delete  all  obligations  of Parent  related  to  filing  and
maintaining  an effective  Form S-4,  (ii) provide for the private  placement of
Parent Common Stock to the Company's  shareholders,  in accordance  with federal
and state securities laws, (iii) create  registration  rights for the benefit of
Company  shareholders  who will receive  Parent  Common  Stock,  (iv) revise the
allocation of the Merger Consideration to the Company's shareholders,  (v) allow
the implementation of procedures to allow the selection of the persons who shall
be  Directors  after  the  Merger,  and  (vi)  clarify  the  parties'  immediate
intentions  in terms of listing the Parent  Common Stock on the  American  Stock
Exchange;

      WHEREAS,  the Board of Directors of the Company has determined  that it is
in the best  interest of the holders of the  Company's  securities  to amend the
Agreement and has adopted this Amendment in accordance with the NCBCA;

      WHEREAS, the Board of Directors of Parent has determined that it is in the
best  interest of the holders of Parent  Common Stock to amend the Agreement and
has adopted this  Amendment in accordance  with the DGCL, and Parent as the sole
shareholder  of Merger Sub, has adopted this  Amendment in  accordance  with the
NCBCA;

      NOW,  THEREFORE,  for good and  valuable  consideration,  the  receipt and
sufficiency of which is hereby acknowledged, the parties hereto, intending to be
legally bound, hereby agree as follows:

                                      -1-
<PAGE>

      ARTICLE 1.  Exhibit A attached  to the  Agreement  shall be deleted in its
entirety and replaced with the Registration  Rights Agreement  referenced herein
and attached as Exhibit A hereto.

      ARTICLE 2.  Exhibit B attached  to the  Agreement  shall be deleted in its
entirety and replaced with Exhibit B attached hereto.

      ARTICLE 3. All references to the  "Proxy/Information  Statement"  shall be
deleted from the Agreement.

      ARTICLE  4.  All  references  to "Form  S-4"  shall  be  deleted  from the
Agreement.

      ARTICLE 5. All  references  to "Initial  Lock Up Period"  shall be deleted
from the Agreement.

      ARTICLE 6. All references to "Resale Prospectus" shall be deleted from the
Agreement."

      ARTICLE 7. Section  2.1(c)  (SERIES A  CONVERTIBLE  EXHANGEABLE  PREFERRED
STOCK)  of  the   Agreement   shall  be  amended  by  deleting  the   percentage
0.000041762166263%  of the Residual Merger Consideration to be issued to holders
for each share of Series A  Preferred  Stock,  and  substituting  the  following
percentage: 0.000041587422187%.

      ARTICLE 8. Section  2.1(d)  (SERIES B  CONVERTIBLE  EXHANGEABLE  PREFERRED
STOCK)  of  the   Agreement   shall  be  amended  by  deleting  the   percentage
0.000029233509085%  of the Residual Merger Consideration to be issued to holders
for each share of Series B  Preferred  Stock,  and  substituting  the  following
percentage: 0.000029111188262%.

      ARTICLE 9. Section  2.1(e)  (SERIES C  CONVERTIBLE  EXHANGEABLE  PREFERRED
STOCK)  of  the   Agreement   shall  be  amended  by  deleting  the   percentage
0.000002923350909%  of the Residual Merger Consideration to be issued to holders
for each share of Series C  Preferred  Stock,  and  substituting  the  following
percentage: 0.000003202230709%.

      ARTICLE 10. Section 2.1(f) (SERIES D-1 CONVERTIBLE PREFERRED STOCK) of the
Agreement shall be amended by deleting the ratio of 1.111111111 shares of Parent
Common  Stock for each  share of Series D-1  Convertible  Preferred  Stock,  and
substituting  therefore the ratio of  1.228070175438600  shares of Parent Common
Stock for each share of Series D-1 Convertible Preferred Stock.

                                      -2-
<PAGE>

      ARTICLE 11. Section 2.1(g) (SERIES D-2 CONVERTIBLE PREFERRED STOCK) of the
Agreement shall be amended by deleting the ratio of 0.761904487 shares of Parent
Common  Stock for each  share of Series D-2  Convertible  Preferred  Stock,  and
substituting  therefore the ratio of  0.842105263157895  shares of Parent Common
Stock for each share of Series D-2 Convertible Preferred Stock.

      ARTICLE 12. Section 2.1(h)  (COMPANY  COMMON STOCK) of the Agreement shall
be amended by deleting the percentage  0.000002923350909% of the Residual Merger
Consideration  to be ISSUED to holders for each share of Company  Common  Stock,
and substituting the following percentage: 0.000002911118826%.

      ARTICLE 13. Section 2.1(j) of the Agreement presently reads as follows:

      "Shares of Parent  Common  Stock issued as Merger  Consideration  shall be
registered under the Securities Act of 1933, as amended (the "Securities  Act"),
pursuant to Section 6.1 hereof. Notwithstanding the foregoing, (A) if Parent has
consummated a Qualified  Financing on or prior to the Closing  Date,  all shares
issued to each holder of Company Common Stock or Company Preferred Stock, as the
case may be, as  Merger  Consideration,  in  excess  of 30,000  shares of Parent
Common Stock shall be subject to a lock-up period  restricting  transfer of such
shares for a period of 12 months after the Closing Date (the  "Lock-Up  Period")
and each certificate  representing  such shares shall bear a restrictive  legend
substantially as set forth on Exhibit A attached hereto or (B) if Parent has not
consummated  a Qualified  Financing on or prior to the Closing  Date,  the first
30,000 (or  fewer)  shares  issued to each  holder of  Company  Common  Stock or
Company  Preferred Stock, as the case may be, as Merger  Consideration  shall be
subject to a lock-up period (the "Initial Lock-Up Period")  restricting transfer
of such shares for a period  ending on the earlier of (i) the 30th day following
the date of  consummation  by Parent of a Qualified  Financing or (ii) the 180th
day following the Closing Date, and each  certificate  representing  such shares
shall bear a restrictive legend substantially as set forth on Exhibit B attached
hereto, and all additional shares issued to such holders as Merger Consideration
shall be subject to a  restriction  on  transfer  of such shares for the Lock-Up
Period,  and each certificate  representing such shares shall bear a restrictive
legend  substantially as set forth on Exhibit A attached hereto.  Separate stock
certificates  shall be issued  representing  the shares of Merger  Consideration
subject to either the Initial Lock-Up Period or the Lock-Up Period."

      Section  2.1(j) of the  Agreement  shall be  deleted in its  entirety  and
replaced with the following:

      "In accordance with and pursuant to a Registration  Rights  Agreement (the
"Registration  Rights  Agreement")  substantially in the form attached hereto as
Exhibit  A and  Section  6.1(a)  of this  Agreement,  Parent  (x)  shall  file a
registration  statement  under  the  Securities  Act of 1933,  as  amended  (the
"Securities  Act"),  to register up to 30,000  shares of Common  Stock issued to
each Company shareholder as Merger  Consideration as soon as practicable after a
Qualified Financing but no later than 150 days following the Effective Time, and
(y) shall use Parent's commercially  reasonable best efforts thereafter to cause
such  registration  statement  to be declared  effective by

                                      -3-
<PAGE>

the  Securities  and Exchange  Commission  ("SEC") as soon as  practicable on or
after the 180th day following the Effective  Time. The parties to this Agreement
acknowledge   and  agree  that  Parent  has  agreed  to  furnish   corresponding
registration   rights  to  Parent's  existing   shareholders  who  do  not  have
freely-trading  shares.  All  shares of  Parent  Common  Stock  issued as Merger
Consideration shall be subject to a lock-up period restricting  transfer of such
shares for a period of 12 months after the Closing Date (the  "Lock-Up  Period")
and each certificate  representing  such shares shall bear a restrictive  legend
reflecting  such  lock-up  arrangement  substantially  as set forth on Exhibit B
attached hereto.  Notwithstanding  the foregoing,  the lock-up arrangement shall
end as to any shares covered by the registration statement to be filed by Parent
pursuant to this  Paragraph  simultaneously  with such shares  being sold by the
holder thereof pursuant to such  registration  statement after that registration
statement  has been  declared  effective by the SEC.  Upon  termination  of this
lock-up  arrangement  with respect to any shares,  the holder thereof may submit
the  certificate  evidencing  the same to  Parent  and  Parent  shall  cause the
restrictive legend to be removed from such certificate in respect of that number
of shares and shall instruct  Parent's transfer agent to remove such restriction
in such transfer agent's records."

      ARTICLE 14. Section  2.1(1)(i)  (AGGREGATE  MERGER  CONSIDERATION)  of the
Agreement  shall be amended by deleting  the  reference  to  "233,807  shares of
Parent  Common  Stock" in  subsection  (d)  thereof  and  substituting  therefor
"234,171 shares of Parent Common Stock".

      ARTICLE 15. Section  2.6(c) (STOCK  OPTIONS) is hereby amended by striking
therefrom  the terms  "the  Securities  and  Exchange  Commission  ("SEC")"  and
substituting therefor the term "the SEC".

      ARTICLE 16. Section 2.7(c) (WARRANTS) of the Agreement  presently reads as
follows:

      "The  Merger  Consideration  allocated  to the Company  Warrants  shall be
reserved for issuance out of the Common Stock Merger Consideration by Parent for
issuance upon exercise in full of all Company  Warrants after the Effective Time
and shall  register  such Parent  Common Stock  reserved  for issuance  upon the
exercise of the Company Warrants on the Form S-4. Notwithstanding the foregoing,
upon the expiration of the Company  Warrants,  such Parent Common Stock reserved
for  issuance  upon the  exercise  of the  Company  Warrants  shall no longer be
reserved and shall be released as treasury stock to Parent."

      Section  2.7(c) of the  Agreement  shall be amended by  deleting  from the
first  sentence  thereof the words "and shall  register such Parent Common Stock
reserved  for  issuance  upon the  exercise of the Company  Warrants on the Form
S-4."

      ARTICLE 17. Section 2.10 (ISSUANCE OF RESTRICTED  SHARES) of the Agreement
presently reads as follows:

      "Any shares of Parent  Common  Stock  issued upon  exercise of any Company
Stock Option or Company Warrant,  or upon conversion of any Company  Convertible
Promissory  Note,  after the  Effective  Time  shall be  issued  as  "restricted
securities,"  as defined in the  Securities  Act,  unless  such shares have been
registered by Parent under the Securities Act in a registration  statement filed
with, and declared effective by, the SEC after the Effective Time."

                                      -4-
<PAGE>

      Section  2.10 shall be  deleted  in its  entirety  and  replaced  with the
following:

            "All shares of Parent  Common Stock issued as Merger  Consideration,
including,  without  limitation,  any shares of Parent  Common Stock issued upon
exercise of any Company Stock Option or Company  Warrant,  or upon conversion of
any  Company  Convertible  Promissory  Note,  shall  be  issued  as  "restricted
securities,"  as  defined  under the  Securities  Act,  and shall be  subject to
transfer  restrictions  under each of Rule 145 and Rule 144 under the Securities
Act and, therefore, may not be sold, transferred or otherwise disposed of except
pursuant to an effective  registration statement under, or in accordance with an
available exemption from the registration and prospectus  delivery  requirements
of, the Securities  Act, and the  certificates  evidencing such shares of Parent
Common Stock or other Parent securities,  if applicable,  shall bear appropriate
restrictive legends and stop transfer orders shall be maintained by the Parent's
transfer  agent in respect of such shares  until such time as such shares are so
registered."

      ARTICLE 18.  Section  3.12(b) (LABOR  MATTERS) of the Agreement  presently
reads as follows:

            Section 3.12(b) of the Company  Disclosure  Schedule lists the name,
title, date of employment and compensation (whether cash or otherwise, including
such items as options) of each  current  officer and  director of the Company or
any of its  subsidiaries,  and each current salaried  employee of the Company or
any of its  subsidiaries.  The execution and delivery of this  Agreement and the
consummation of the  transactions  contemplated  hereby and thereby will not (i)
result in any  payment  (including  severance,  unemployment  compensation,  tax
gross-up,  bonus or otherwise)  becoming due to any current or former  director,
employee or  independent  contractor of the Company or any of its  subsidiaries,
from  the  Company  or  any of its  subsidiaries  under  any  Employee  Plan  or
otherwise,  (ii) materially  increase any benefits  otherwise  payable under any
Employee Plan or otherwise,  or (iii) result in the  acceleration of the time of
payment, exercise or vesting of any such benefits.

      Subsection  (iii) of the  second  sentence  of  Section  3.12(b)  shall be
amended by adding at the end of such clause the words "other than the vesting of
the Company Stock Options at the Effective Time."

      ARTICLE 19.  Section  3.24  (ACCURACY  OF  INFORMATION)  of the  Agreement
presently reads as follows:

      "To the  knowledge of the Company,  neither  this  Agreement,  the Company
Disclosure Schedule nor any other document,  schedule,  exhibit,  certificate or
instrument  provided by the Company or any of the Company's  subsidiaries or any
of their  respective  employees  or  agents to  Parent  in  connection  with the
transactions contemplated hereby contains an untrue statement of a material fact
or omits to state a material  fact  necessary to make the  statements  contained
therein,  not misleading.  None of the information supplied or to be supplied by
the Company in writing  specifically for inclusion or incorporation by reference
in (i) the Form S-4 will, at the time the Form S-4 becomes  effective  under the
Securities Act, contain any untrue statement of a material fact or omit to state
any  material  fact  required  to be stated  therein  or  necessary  to make the
statements therein, not misleading or (ii) the Proxy/Information Statement will,
at the date it is first mailed to the Company's  shareholders and at the time of
the Company  Shareholders  Meeting,  contain any untrue  statement of a material
fact or omit to state  any  material  fact  required  to be  stated  therein  or
necessary to make the statements  therein,  in light of the circumstances  under
which they are made, not misleading,  except that no  representation or warranty
is made by the Company  with  respect to  statements  made based on  information
supplied by Parent  specifically  for inclusion or incorporation by reference in
the Form S-4 or Proxy/Information Statement."

                                      -5-
<PAGE>

      Section  3.24 shall be  deleted  in its  entirety  and  replaced  with the
following:

      "To the  knowledge of the Company,  neither  this  Agreement,  the Company
Disclosure Schedule nor any other document,  schedule,  exhibit,  certificate or
instrument  provided by the Company or any of the Company's  subsidiaries or any
of  their  respective  employees  or  agents  to  Parent  or  to  the  Company's
shareholders in connection with the transactions contemplated hereby, including,
without  limitation,  the Company's Proxy Statement  prepared by the Company and
delivered to the  Company's  shareholders,  or the  information  concerning  the
Company, its business,  its properties,  its condition (financial or otherwise),
its  plans  and its  prospects  which  has been  included  in  Parent's  Private
Placement  Memorandum,  contains an untrue statement of a material fact or omits
to state a material fact necessary to make the statements  contained therein, in
light of the  circumstances  under  which  they are made,  not  misleading.  The
Company  specifically  acknowledges that the foregoing  representation  shall be
true in respect of the Company's Proxy Statement prepared by the Company and the
aforesaid   information  included  in  Parent's  Private  Placement  Memorandum,
respectively,  at the date of such Proxy  Statement  and such Private  Placement
Memorandum,  and at all times thereafter through the Effective Date. The Company
makes no  representation  whatsoever  as to any other  information  in  Parent's
Private Placement Memorandum."

      ARTICLE 20. Section 4.3(a) (CAPITAL  STRUCTURE) of the Agreement presently
reads as follows:

      "The authorized  capital stock of Parent consists of 100,000,000 shares of
common  stock,  $0.001 par value (the "Parent  Common  Stock"),  and  25,000,000
shares of  preferred  stock,  par value  $0.001  per share,  of Parent  ("Parent
Authorized  Preferred  Stock").  As of the date hereof: (i) 28,704,861 shares of
Parent  Common Stock were issued and  outstanding;  (ii) no (0) shares of Parent
Common Stock were held by Parent in its treasury;  (iii) no (0) shares of Parent
Common Stock were held by subsidiaries of Parent;  (iv) approximately  8,680,000
shares of Parent  Common  Stock  were  reserved  for  issuance  pursuant  to the
stock-based  plans identified in Section 4.3 of the Parent  Disclosure  Schedule
(such plans, collectively,  the "Parent Stock Plans"), of which approximately no
(0) shares are subject to outstanding  employee stock options or other rights to
purchase or receive  Parent  Common Stock  granted  under the Parent Stock Plans
(collectively,  "Parent  Employee Stock  Options");  and (v) 7,637,500 shares of
Parent Common Stock are reserved for issuance pursuant to convertible securities
or  warrants  (including  5,500,000  warrants  at  $1.50  heretofore  issued  to
Bioaccelerate,   Inc.  and   1,500,000   warrants  at  $3.00  to  be  issued  to
Bioaccelerate  in consideration  of the $4,000,000  bridge financing  heretofore
agreed among the parties, and 637,500 shares reserved for issuance in respect of
contingent obligations)."

                                      -6-
<PAGE>

      Section  4.3(a) shall be deleted in its  entirety  and  replaced  with the
following:

      "The authorized  capital stock of Parent consists of 100,000,000 shares of
common  stock,  $0.001 par value (the "Parent  Common  Stock"),  and  25,000,000
shares of  preferred  stock,  par value  $0.001  per share,  of Parent  ("Parent
Authorized  Preferred  Stock").  As of the date hereof: (i) 29,172,833 shares of
Parent  Common Stock were issued and  outstanding;  (ii) no (0) shares of Parent
Common Stock were held by Parent in its treasury;  (iii) no (0) shares of Parent
Common Stock were held by subsidiaries of Parent;  (iv) approximately  8,680,000
shares of Parent  Common  Stock  were  reserved  for  issuance  pursuant  to the
stock-based  plans identified in Section 4.3 of the Parent  Disclosure  Schedule
(such plans, collectively,  the "Parent Stock Plans"), of which approximately no
(0) shares are subject to outstanding  employee stock options or other rights to
purchase or receive  Parent  Common Stock  granted  under the Parent Stock Plans
(collectively,  "Parent  Employee Stock  Options");  and (v) 7,258,618 shares of
Parent Common Stock are reserved for issuance pursuant to convertible securities
or  warrants  (including  5,500,000  warrants  at  $1.50  heretofore  issued  to
Bioaccelerate,   Inc.  and   1,500,000   warrants  at  $3.00  to  be  issued  to
Bioaccelerate  in consideration  of the $4,000,000  bridge financing  heretofore
agreed among the parties, and 258,618 shares reserved for issuance in respect of
contingent obligations)."

      ARTICLE 21.  Section  4.22  (ACCURACY  OF  INFORMATION)  of the  Agreement
presently reads as follows:

      "To the knowledge of Parent, neither this Agreement, the Parent Disclosure
Schedule nor any other document,  schedule,  exhibit,  certificate or instrument
provided by the Parent, any of the Parent's  subsidiaries,  Merger Sub or any of
their  respective  employees  or agents to the  Company in  connection  with the
transactions contemplated hereby contains an untrue statement of a material fact
or omits to state a material  fact  necessary to make the  statements  contained
therein,  not misleading.  None of the information supplied or to be supplied by
Parent  specifically for inclusion or incorporation by reference in (i) the Form
S-4 will, at the time the Form S-4 becomes  effective  under the Securities Act,
contain any untrue  statement  of a material  fact or omit to state any material
fact required to be stated therein or necessary to make the  statements  therein
not misleading or (ii) the  Proxy/Information  Statement will, at the date it is
first  mailed  to the  Company's  shareholders  and at the  time of the  Company
Shareholders Meeting, contain any untrue statement of a material fact or omit to
state any material fact  required to be stated  therein or necessary in order to
make the statements  therein, in light of the circumstances under which they are
made, not misleading,  in either case, no  representation or warranty is made by
Parent with respect to  statements  made or  incorporated  by reference  therein
based on  information  supplied by the Company  specifically  for  inclusion  or
incorporation by reference in the Form S-4 or Proxy/Information  Statement.  The
Form S-4 will comply as to form in all material  respects with the  requirements
of the Securities Act and the rules and regulations thereunder."

      Section  4.22 shall be  deleted  in its  entirety  and  replaced  with the
following:

                                      -7-
<PAGE>

"To the  knowledge of Parent,  neither  this  Agreement,  the Parent  Disclosure
Schedule nor any other document,  schedule,  exhibit,  certificate or instrument
provided by the Parent, any of the Parent's  subsidiaries,  Merger Sub or any of
their  respective  employees  or  agents  to the  Company  or to  the  Company's
shareholders in connection with the transactions  contemplated hereby including,
without limitation,  Parent's Private Placement  Memorandum,  contains an untrue
statement of a material fact or omits to state a material fact necessary to make
the statements contained therein, in light of the circumstances under which they
are made, not misleading.  Parent  specifically  acknowledges that the foregoing
shall be true in respect of Parent's Private Placement Memorandum at the date of
such  Private  Placement  Memorandum  and at all times  thereafter  through  the
Effective Date.  Notwithstanding  the foregoing,  Parent makes no representation
with respect to information in the Private Placement  Memorandum  concerning the
Company, its business,  its properties,  its condition (financial or otherwise),
its plans and its prospects  insofar as such information was furnished to Parent
by the  Company  and Parent has relied  upon the  accuracy  of such  information
furnished by the Company."

      ARTICLE 22.  Section 5.4 (CONDUCT OF BUSINESS BY PARENT) of the  Agreement
is amended by addition of the following at the end of the Section:

      "In addition,  notwithstanding the foregoing, and anything to the contrary
in this Agreement,  the parties  acknowledge and agree that Parent may amend its
bylaws as necessary or  appropriate  by resolution of its Board of Directors (x)
to ratify the number of directors constituting Parent's Board of Directors,  (y)
to increase the number of directors  constituting Parent's Board of Directors in
order that the number of  directors  constituting  Parent's  Board of  Directors
shall be four (4) directors  thereafter up until the Effective  Time, and (z) to
increase the number of directors  constituting Parent's Board of Directors as of
the Effective Time in order that the number of directors  constituting  Parent's
Board of Directors  shall be seven (7)  directors as of the  Effective  Time. In
addition,  Parent's  Board of  Directors  may fill the  vacancies  so created in
accordance  with Section 6.9 of this  Agreement.  Each of the foregoing  actions
shall  constitute a "Permitted  Parent  Action",  and no such  Permitted  Parent
Action shall be deemed to breach any Parent representation,  warranty,  covenant
or agreement in this Agreement."

      ARTICLE 23. Section 6.1  (PREPARATION  OF THE FORM S-4,  PROXY/INFORMATION
STATEMENT) of the Agreement presently reads as follows:

      "SECTION 6.5  PREPARATION OF THE FORM S-4,  PROXY/INFORMATION  STATEMENT .
(A) As promptly as  practicable  following  the date of this  Agreement,  Parent
shall  prepare  and  file  with the SEC (and the  Company  shall  cooperate  and
participate in the  preparation  of) a  Registration  Statement on Form S-4 (the
"Form  S-4"),  in  which  an  information   statement  (the   "Proxy/Information
Statement")  shall be included as a prospectus and in which a resale  prospectus
(the "Resale  Prospectus")  shall be included for the purpose of permitting  the
Parent  Common Stock issued to those  affiliates  of the Company  identified  in
Section 6.10 of the Company Disclosure  Schedule to be resold by such affiliates
as provided in the last sentence of this Section 6.1(a),  subject to the Initial
Lock-Up  Period and the Lock-Up  Period.).  Each of Parent and the Company shall
use their reasonable best efforts to have the Form S-4 and the Resale Prospectus
declared effective under the Securities Act and the Proxy/Information  Statement
"cleared"  by the  SEC's  staff  for  mailing  in  connection  with the  Company
Shareholder Meeting as promptly as practicable after such filing. As promptly as
practicable  after the Form S-4 is declared  effective,  the Company shall cause
the Proxy/Information  Statement to be mailed to its shareholders.  In the event
that the Resale  Prospectus has not remained in effect,  Parent shall file, with
the SEC, no later than one (1) year after the  Effective  Date,  a  registration
statement under the Securities Act and a resale  prospectus  covering all shares
subject to the Resale  Prospectus  and those  shares held by  affiliates  of the
Parent.

                                      -8-
<PAGE>

      (B) The  Company  and  Parent  shall  cooperate  with one  another  (i) in
connection with the preparation of the Proxy/Information  Statement and the Form
S-4, (ii) in determining whether any other action by or in respect of, or filing
with, any governmental  body,  agency or official,  or authority or any actions,
consents,  approvals or waivers are required to be obtained  from parties to any
leases and other material  contracts in connection with the  consummation of the
Merger, and (iii) in seeking any such actions, consents, approvals or waivers or
making any such filings, furnishing information required in connection therewith
or with the  Proxy/Information  Statement or the Form S-4 and seeking  timely to
obtain any such actions, consents, approvals or waivers.

      (C) Parent shall use its commercially reasonable efforts to obtain consent
from its  shareholders for all other actions  contemplated  herein which require
the consent of the  shareholders  of Parent,  including  without  limitation the
actions set forth in Section 6.9.

      (D) The  Company  shall  furnish  to Parent  and to  Parent's  independent
certified public  accountants such workpapers and supporting  documentation,  as
well as such consents by the Company's independent public certified accountants,
as Parent or Parent's  independent  certified public  accountants may reasonably
require in order to include the Company's  financial  statements and the related
reports of Company's independent certified public accountants in Parent's filing
with the SEC on Form S-4 or any other filing  required to be made by Parent with
the SEC.

      (E) On or prior to the filing of Parent's  registration  statement on Form
S-4 contemplated by this Agreement, the Company shall have furnished or arranged
to  be  furnished  to  Parent  and  to  Parent's  independent  certified  public
accountants such Company financial statements, audited and unaudited (including,
without limitation,  the Company Financial  Statements and financial  statements
for  such  additional  periods  as may be  required  under  applicable  laws and
regulations),  workpapers and supporting documentation, as well as such consents
by the Company's  independent  public  certified  accountants,  as are Parent or
Parent's   independent   certified  public  accountants  shall  have  reasonably
requested or may  reasonably  require in order to include the Company  financial
statements and the related  reports of Company's  independent  certified  public
accountants,  in  satisfaction of all applicable SEC rules and  regulations,  in
Parent's  registration  statement  on  Form  S-4 to be  filed  with  the  SEC as
contemplated  by this Agreement and rely upon the same. The Company's  financial
statements  included  in the Form S-4  shall,  at the time of filing of the Form
S-4, satisfy the relevant SEC financial reporting and filing requirements.

                                      -9-
<PAGE>

      (F) On or prior to the Effective Time, the Company shall have furnished or
arranged to be furnished to Parent and to Parent's independent  certified public
accountants  such  workpapers  and  supporting  documentation,  as  well as such
consents by the  Company's  independent  public  certified  accountants,  as are
Parent  or  Parent's   independent   certified  public  accountants  shall  have
reasonably  requested or may reasonably  require in order to include the Company
financial statements and the related reports of Company's  independent certified
public accountants, in satisfaction of all applicable SEC rules and regulations,
in  Parent's  registration  statement  on Form S-4 as the same  shall  have been
amended,  if at all,  by Parent  and as the Parent  same  shall  have  requested
acceleration of effectiveness by the SEC as contemplated by this Agreement,  and
rely upon the same. The Company's financial  statements included in the Form S-4
shall, at the time of  effectiveness  of the Form S-4,  satisfy the relevant SEC
financial reporting and filing requirements.

      (G) On or prior to the Effective Time, and in any event, as required prior
to such date in  connection  with any  filings  or  disclosures  Parent may deem
necessary to make under applicable  securities laws, the Company will furnish to
Parent and to Parent's  independent  certified public accountants such financial
statements,  and such workpapers and supporting  documentation,  as well as such
consents by the Company's independent public certified accountants, as Parent or
Parent's  independent  certified public accountants have reasonably requested or
may reasonably require in order to include the Company Financial  Statements and
the related reports of Company's  independent  certified  public  accountants in
Parent's  filing with the SEC on Form 8-K  covering  this  Agreement or in other
disclosures  or  filings  that  Parent  may  deem it  necessary  to  make  under
applicable securities laws, and rely upon the same."

      Section 6.1 of the Agreement shall be deleted in its entirety and replaced
with the following:

            "SECTION 6.1  Preparation of the Proxy  Statement and Preparation of
the Private Placement Memorandum.

            (A) Following the date of this Agreement,  the Company shall prepare
the Proxy Statement (the "Proxy Statement") which shall be mailed by the Company
to the Company's  security  holders in connection  with the Company  Shareholder
Meeting as promptly as practicable upon completion.  In addition,  following the
date of this Agreement,  Parent shall prepare the Private  Placement  Memorandum
(the "PPM") of Parent covering the Parent  securities to be issued in connection
with the Merger,  and which also shall be  delivered to the  Company's  security
holders.

            (B) The Company and Parent shall  cooperate  with one another (i) in
connection  with the  preparation  of the Proxy  Statement  and the PPM, (ii) in
determining  whether any filings are required under federal and state securities
laws,  (iii) in  determining  whether  any

                                      -10-
<PAGE>

other action by or in respect of, or filing with, any governmental  body, agency
or official,  or authority  or any actions,  consents,  approvals or waivers are
required to be obtained from parties to any leases and other material  contracts
in connection with the consummation of the Merger,  and (iv) in seeking any such
actions, consents,  approvals or waivers or making any such filings,  furnishing
information required in connection therewith or with the Proxy Statement and the
PPM and  seeking  timely to obtain  any such  actions,  consents,  approvals  or
waivers.

            (C) Parent shall use its commercially  reasonable  efforts to obtain
consent from its  shareholders for all other actions  contemplated  herein which
require the consent of the shareholders of Parent,  including without limitation
the actions set forth in Section 6.9.

            (D) The Company shall furnish to Parent and to Parent's  independent
certified public  accountants such workpapers and supporting  documentation,  as
well as such consents by the Company's independent public certified accountants,
as Parent or Parent's  independent  certified public  accountants may reasonably
require in order to include the Company's  financial  statements and the related
reports of Company's  independent  certified  public  accountants  in any filing
required to be made by Parent with the SEC as a result of the Merger.

            (E) On or prior to the Effective Time, and in any event, as required
on prior to such date in connection  with any filings or disclosures  Parent may
deem  necessary  to make  under  applicable  securities  laws as a result of the
Merger,  including without limitation any Current Report on Form 8-K to be filed
after the Merger with  respect to the  consummation  of the Merger,  the Company
will furnish to Parent and to Parent's independent  certified public accountants
such financial statements, and such workpapers and supporting documentation,  as
well as such consents by the Company's independent public certified accountants,
as Parent or Parent's  independent  certified public accountants have reasonably
requested or may  reasonably  require in order to include the Company  Financial
Statements and the related  reports of Company's  independent  certified  public
accountants in Parent's filings with the SEC on Form 8-K covering this Agreement
or the consummation of the Merger or in other disclosures or filings that Parent
may deem it necessary to make under  applicable  securities  laws, and rely upon
the same.

      ARTICLE 24. Section 6.2 (SHAREHOLDERS' MEETING) of the Agreement presently
reads as follows:

      "The  Company  shall  cause a meeting of its  shareholders  (the  "Company
Shareholders  Meeting") to be duly called and held within 30 days  following the
effective date of the Form S-4 for the purpose of voting on the adoption of this
Agreement."

      Section 6.2 of the Agreement shall be deleted in its entirety and replaced
with the following:

                                      -11-
<PAGE>

      "The  Company  shall  cause a meeting of its  shareholders  (the  "Company
Shareholders  Meeting")  to be duly called and held by December 13, 2004 for the
purpose of voting on the adoption of this Agreement."

      ARTICLE  25.  Section  6.3  (LETTERS  OF  COMPANY'S  ACCOUNTANTS)  of  the
Agreement shall be deleted in its entirety and replaced with the following:

            "SECTION 6.3 INTENTIONALLY DELETED."

      ARTICLE 26.  Section 6.7 (FEES AND EXPENSES) of this  Agreement  presently
reads as follows:

      "All costs, fees and expenses incurred in connection with the Merger, this
Agreement  (including all instruments  and agreements  prepared and delivered in
connection herewith), and the transactions  contemplated by this Agreement shall
be paid by the party incurring such fees or expenses; provided that, the Company
shall cause all of its fees and  expenses  to be paid prior to the  Merger,  and
shall  cause  it's  principal  creditors  (including,  without  limitation,  its
investment  bankers,  attorneys and accountants) in respect of transaction costs
to confirm to Parent  immediately prior to the Effective Time that all such fees
and  expenses  are paid and none are  unbilled.  In further  explication  of the
preceding sentence,  but without limiting the same, all costs, fees and expenses
(including,  but not  limited to,  legal and  accounting  fees)  incurred by the
Company in connection with the Proxy/Information  Statement shall be paid by the
Company;  provided, that the parties acknowledge and agree that the Parent shall
take the lead in preparing  the Form S-4, and the Parent shall pay its legal and
accounting expenses in connection with the Form S-4 and the Resale Prospectus."

      The second  sentence of Section 6.7 of the  Agreement  shall be deleted in
its entirety and replaced with the following:

      "In further  explication of the preceding  sentence,  but without limiting
the same, all costs, fees and expenses (including, but not limited to, legal and
accounting  fees) incurred by the Company in connection with the Proxy Statement
and the PPM shall be paid by the Company, and the Company shall take the lead in
preparing the Proxy Statement,  provided, that the parties acknowledge and agree
that Parent shall take the lead in  preparing  the PPM, and Parent shall pay the
legal and accounting  expenses that Parent incurs in connection with the PPM and
the Proxy Statement."

      ARTICLE 27.  Section  6.9(b)  (CORPORATE  GOVERNANCE OF PARENT)  presently
reads as follows:

      "At the Effective Time, (i) Parent's  directors not continued in office as
hereinafter  provided shall resign,  (ii) the board shall be increased from five
to seven directors,  and (iii) the seven seats initially shall be filled by vote
of the Parent's directors continuing in office to fill the vacancies so created,
as follows: the Chairman and CEO shall be Christopher Every, three directors (at
least two (2) of whom shall be  independent)  shall be  appointed by Parent with
the consent of Company, not to be unreasonably withheld, and three directors (at
least two (2) of whom shall be  independent)  shall be  appointed by the Company
with  the  consent  of  Parent,  not to be  unreasonably  withheld,  to serve in
accordance with Parent's articles of incorporation and by-laws."

                                      -12-
<PAGE>

      Section  6.9(b) of the  Agreement  shall be  deleted in its  entirety  and
replaced as follows:

      "At the  Effective  Time, if it has not already done so, Parent shall take
such actions, to cause the number of directors  comprising the Parent's Board of
Directors to be increased to seven (7)  directors  effective as of the Effective
Time.  Of  the  individuals  comprising  those  seven  (7)  directors  as of the
Effective  Time, (i) one of the directors of Parent shall be Christopher  Every,
the  Chairman  and  CEO,  (ii)  three  (3) of  those  directors  shall  be  such
individuals as shall have been elected by Parent's  shareholders  or by Parent's
Board of Directors to fill  vacancies  created on Parent's  Board of  Directors,
provided that at least two (2) of such three (3) shall be independent, and (iii)
three  directors  (at  least  two (2) of whom  shall  be  independent)  shall be
nominees  designated by the Company's  Board of Directors prior to the Effective
Time and appointed by Parent's  Board of Directors to fill vacancies on Parent's
Board of Directors  effective as of the Effective Time. All such directors shall
serve in accordance with Parent's articles of incorporation and by-laws."

      ARTICLE 28. Section 6.10 (AGREEMENTS  WITH HOLDERS OF COMPANY  SECURITIES)
presently reads as follows:

      "AGREEMENTS WITH HOLDERS OF COMPANY SECURITIES.  The Company shall use its
reasonable  best  efforts to obtain and deliver to Parent not later than 30 days
after the date hereof a written  agreement,  reasonably  acceptable to Parent in
form and in substance, of all persons who are (or may deemed to be) "affiliates"
of the Company for purposes of Rule 145 under the  Securities  Act (each of whom
shall be so  identified  in Section  6.10 of the Company  Disclosure  Schedule).
Notwithstanding any other provision of this Agreement, any person whatsoever who
shall not have executed and delivered to Parent a written  agreement  reasonably
acceptable  to Parent in form and  substance  as provided in this  Section  6.10
shall not be entitled to have the Merger  Consideration  issued in the Merger to
such  person  covered by (and shall not be entitled to be included as a "selling
stockholder"  in) the Resale  Prospectus.  The written  agreement shall include,
without limitation,  provisions setting forth the restrictions under the Initial
Lock-Up Period and the Lock-Up  Period,  customary  stockholder  information for
inclusion  of shares in the Resale  Prospectus,  and  customary  agreements  and
indemnifications  by such stockholders in connection with the Resale Prospectus.
Promptly after the expiration of such 30-day period,  the Company shall cause to
be delivered to each affiliate that shall not so execute such written  agreement
as  provided in this  Section  6.10 a  statement  disclosing  that the shares of
Parent  Common  Stock  or  other  Merger   Consideration   (including,   without
limitation, securities issuable to holders of Company Options, Company Warrants,
and  Company  Convertible  Promissory  Notes) to be issued  to such  person  are
subject to transfer  restrictions  under each of Rule 145 and Rule 144 under the
Securities  Act  and,  therefore,  may not be  sold,  transferred  or  otherwise
disposed of except pursuant to an effective  registration statement under, or in
accordance  with an available  exemption  from the  registration  and prospectus
delivery  requirements  of,  the  Securities  Act,  and  that  the  certificates
evidencing  such shares of Parent  Common Stock or other Parent  securities,  if
applicable,  shall bear appropriate restrictive legends and stop transfer orders
shall be maintained by the Parent's transfer agent in respect of such shares."

                                      -13-
<PAGE>

      Section  6.10 shall be  deleted  in its  entirety  and  replaced  with the
following:

      "AGREEMENTS WITH HOLDERS OF COMPANY SECURITIES.  The Company shall use its
reasonable  best  efforts to obtain and deliver to Parent not later than 30 days
after the date hereof a written  agreement,  reasonably  acceptable to Parent in
form and in substance, of all persons who are (or may deemed to be) "affiliates"
of the Company for purposes of Rule 145 under the  Securities  Act (each of whom
shall be so  identified  in Section  6.10 of the Company  Disclosure  Schedule).
Promptly after the expiration of such 30-day period,  the Company shall cause to
be delivered to each affiliate that shall not so execute such written  agreement
as  provided in this  Section  6.10 a  statement  disclosing  that the shares of
Parent  Common  Stock  or  other  Merger   Consideration   (including,   without
limitation, securities issuable to holders of Company Options, Company Warrants,
and  Company  Convertible  Promissory  Notes) to be issued  to such  person  are
subject to transfer  restrictions  under each of Rule 145 and Rule 144 under the
Securities  Act  and,  therefore,  may not be  sold,  transferred  or  otherwise
disposed of except pursuant to an effective  registration statement under, or in
accordance  with an available  exemption  from the  registration  and prospectus
delivery  requirements  of,  the  Securities  Act,  and  that  the  certificates
evidencing  such shares of Parent  Common Stock or other Parent  securities,  if
applicable,  shall bear appropriate restrictive legends and stop transfer orders
shall be maintained by the Parent's transfer agent in respect of such shares."

      ARTICLE 29. Section 6.16(a) (CONTINGENT FEE SHARES) of the Agreement shall
be amended by deleting the reference to "233,807  shares of Parent Common Stock"
and substituting therefor "234,171 shares of Parent Common Stock".

      ARTICLE 30. A new Section 6.17  (APPLICATION TO LIST MERGER  CONSIDERATION
SHARES  ON THE  AMERICAN  STOCK  EXCHANGE)  shall be added to the  Agreement  as
follows:

      "SECTION  6.17  APPLICATION  TO LIST  MERGER  CONSIDERATION  SHARES ON THE
AMERICAN  STOCK  EXCHANGE.  Parent  will use its  commercially  reasonable  best
efforts  to take,  or cause to be taken,  all  action  and to do, or cause to be
done,  all things  necessary,  proper or  advisable in order to  effectuate  the
listing of the shares of Common Stock  constituting the Merger  Consideration on
the American Stock  Exchange as soon as practicable  after the Effective Time of
the Merger;  provided  that the foregoing  shall not require  Parent to take any
action or agree to any  condition or incur any expense or liability  that might,
in the reasonable  judgment of Parent,  have a material adverse effect on Parent
or its  shareholders,  or that,  in the  reasonable  exercise  of the  fiduciary
responsibilities  of Parent's Board of Directors (as  constituted  subsequent to
the Merger),  is deemed by them to not be in the best interests of Parent or its
shareholders."

            ARTICLE 31. A new Section 6.18  (REGISTRATION OF PARENT  OUTSTANDING
WARRANTS) shall be added to the Agreement as follows:

                                      -14-
<PAGE>

            "SECTION 6.18. REGISTRATION OF PARENT OUTSTANDING WARRANTS. (a) With
respect to the shares of Parent  Common  Stock  issuable  upon the  exercise  by
Bioaccelerate,  Inc.  of  warrants to purchase  Parent  Common  Stock  issued to
Bioaccelerate,  Inc. prior to the date hereof,  Parent shall file, no later than
180  days  after  the  Effective  Time,  with the SEC a  registration  statement
registering the shares of Parent Common Stock  underlying such warrants.  Parent
will use its best efforts to have such registration  statement become and remain
continuously  effective  under the  Securities  Act and,  if the Company is then
listed  on a  national  stock  exchange,  file  with  such  exchange  a  listing
application  and use its best  efforts to have such  shares  admitted to trading
thereon upon exercise of such warrants.

            (b) Prior to the Effective Time,  Parent shall obtain and deliver to
Company a written  agreement,  reasonably  satisfactory  to  Company in form and
substance,  from  Bioaccelerate,  Inc. agreeing that all shares of Parent Common
Stock  received  after the  Effective  Time upon  exercise of  warrants  held by
Bioaccelerate, Inc., other than 1,500,000 shares of Parent Common Stock, will be
subject to the lock-up provisions set forth in Section 2.1(j) during the Lock-Up
Period."

      ARTICLE 32.  Section 7.1 (d)  (CONDITIONS  TO EACH PARTY'S  OBLIGATION  TO
EFFECT  THE  MERGER)  which  pertains  to the Form S-4,  shall be deleted in its
entirety and replaced with the following:

      "(D) Registration  Rights Agreement.  The parties each shall have executed
and delivered to the other the Registration  Rights  Agreement  substantially in
the form of Exhibit A to this Agreement."

      ARTICLE 32.  Section 7.1(e) (STOCK  EXCHANGE  LISTING) shall be deleted in
its entirety and replaced with the following:

      "Parent shall have endeavored to cause the shares of Common Stock issuable
to  the  Company's   shareholders   pursuant  to  this  Agreement  to  meet  all
requirements  for  listing on the AMEX other than any  requirement  of a minimum
market price of Enhance's  Common Stock, and shall have filed an application for
listing on the AMEX. However,  the parties acknowledge and agree that Parent may
not have satisfied all such requirements  prior to closing  (including,  without
limitation,  election of sufficient  independent  directors and Board  committee
members  prior  to  the  Effective   Time),  and  satisfaction  of  all  listing
requirements is not a condition of closing."

                  [Remainder of page intentionally left blank.]

                                      -15-
<PAGE>

      IN WITNESS  WHEREOF,  Parent,  the Company and Merger Sub have caused this
Amendment to be signed by their respective  officers  thereunto duly authorized,
all as of the date first written above.

                                       ENHANCE BIOTECH, INC.

                                       By  /s/  Christopher Every
                                           --------------------------------
                                             Christopher Every
                                             President and CEO

                                       ARDENT ACQUISITION CORP.

                                       By  /s/  Christopher Every
                                           --------------------------------
                                             Christopher Every
                                             President and CEO

                                       ARDENT PHARMACEUTICALS, INC.

                                       By  /s/  Kwen-Jen Chang
                                           --------------------------------
                                            Kwen-Jen Chang
                                            President and CEO

<PAGE>

                                    EXHIBIT B

                              LOCK-UP PERIOD LEGEND

      The shares  represented by this Certificate are subject to restrictions on
transfer until ___________,  2005 (one year from the date of the consummation of
the transactions  contemplated by that certain Merger Agreement dated August 11,
2004, as amended (the "Merger Agreement"), among the Company, Ardent Acquisition
Corp., and Ardent  Pharmaceuticals,  Inc.) as set forth in Section 2.1(j) of the
Merger  Agreement.  Copies  of the  Merger  Agreement  are  maintained  and  are
available for inspection at the principal office of the Company.EXHIBIT 10.3

                          REGISTRATION RIGHTS AGREEMENT

      REGISTRATION RIGHTS AGREEMENT (the "Agreement"), dated as of December ___,
2004, is entered into by and among ENHANCE BIOTECH, INC., a Delaware corporation
("Parent"),  ARDENT ACQUISITION  CORP., a North Carolina  corporation and wholly
owned  subsidiary of Parent ("Merger Sub") and ARDENT  PHARMACEUTICALS,  INC., a
North Carolina corporation ("Ardent").

                              W I T N E S S E T H:

            WHEREAS,  Parent,  Merger  Sub and  Ardent  have  entered  into that
certain  Merger  Agreement  dated August 11, 2004, as amended as of November 20,
2004  (the  "Merger  Agreement"),  pursuant  to which  Parent  and  Ardent  have
consummated  a business  combination  whereby  Merger  Sub merged  with and into
Ardent and each  outstanding  security of Ardent was converted into the right to
receive the Merger Consideration;

            WHEREAS, in connection with the conversion of Ardent securities into
the Merger  Consideration,  Parent has  agreed to provide  certain  registration
rights pursuant to the terms of this Agreement;

            NOW,  THEREFORE,  in  consideration  of  the  mutual  covenants  and
obligations  hereinafter set forth, the parties hereto,  intending to be legally
bound, hereby agree as follows:

      1.  Definitions.  Capitalized  terms used and not otherwise defined herein
that are defined in the Merger Agreement shall have the meaning ascribed to such
terms in the Merger  Agreement.  As used in this  Agreement the following  terms
shall have the following meanings:

            1.1 "Commission"  shall mean the Securities and Exchange  Commission
or any other federal agency at the time administering the Securities Act.

            1.2 "Common Stock" shall mean shares of Parent's  common stock,  par
value $0.001 per share.

            1.3 "Exchange Act" shall mean the  Securities  Exchange Act of 1934,
as amended, or any similar federal statute enacted hereafter,  and the rules and
regulations  of the  Commission  thereunder,  all as the same shall be in effect
from time to time.

            1.4  "Filing  Date"  shall mean the date which is the earlier of the
following:  (x)  as  soon  as  practicable  after  consummation  of a  Qualified
Financing;  or (y) the date which is not more than the 150th day  following  the
Effective Date of the Merger.

<PAGE>

            1.5 "Form  SB-2"  means  such form  under the  Securities  Act as in
effect on the date  hereof or any  registration  form under the  Securities  Act
subsequently  adopted by the Commission which permits inclusion or incorporation
of substantial  information by reference to other documents filed by Parent with
the Commission.

            1.6  "Holder"  shall  mean any  security  holder  of  Ardent to whom
Registrable Securities are issued pursuant to the Merger Agreement.

            1.7  "Person"  shall  mean  any   individual,   firm,   corporation,
partnership,  trust, incorporated or unincorporated association,  joint venture,
joint stock company,  government (or an agency or political subdivision thereof)
or other entity of any kind.

            1.8  "Prospectus"   shall  mean  the  prospectus   included  in  the
Registration Statement, as amended or supplemented by any prospectus supplement,
with  respect to the terms of the  offering  of any  portion of the  Registrable
Securities covered by the Registration  Statement,  and all other amendments and
supplements to the  Prospectus,  including  post-effective  amendments,  and all
material  incorporated by reference or deemed to be incorporated by reference in
such Prospectus.

            1.9 "Qualified  Financing" means an equity financing by Parent of at
least $10,000,000 with a minimum valuation of at least $1.50 per share of Common
Stock.

            1.10 "Registration  Statement" shall mean the registration statement
required  to be  filed  hereunder,  including  the  Prospectus,  amendments  and
supplements to such  registration  statement or  Prospectus,  including pre- and
post-effective  amendments,  all exhibits thereto, and all material incorporated
by reference  or deemed to be  incorporated  by  reference in such  registration
statement.

            1.11  "Registrable  Securities"  shall mean for each  Holder,  up to
30,000  shares of Common  Stock  issued to such  Holder  pursuant  to the Merger
Agreement at the Effective Time;  provided,  however,  that the shares of Common
Stock  reserved  pursuant to the Merger  Agreement for issuance upon exercise or
conversion of Ardent stock options,  warrants and convertible  promissory  notes
shall not be deemed "Registrable  Securities" if such stock options and warrants
were not  exercised  prior to or at the  Effective  Time or if such  convertible
promissory notes were not converted prior to or at the Effective Time; provided,
however, that the term "Registrable Securities" shall not include (i) any shares
of Common Stock that have been  registered and sold pursuant to a  registration,
or (ii) any shares of Common  Stock  that have been sold,  or could then be sold
within any three (3) month period,  pursuant to Rule 144  promulgated  under the
Securities Act.

            1.12  "Registration  Expenses"  shall mean all of Parent's  expenses
relating to Parent's compliance with Sections 2 and 3 hereof, including, without
limitation,  all SEC and "blue  sky"  registration  and  filing  fees,  printing
expenses, fees for listing on any national exchange on which Parent may list the
Registrable  Shares,  any transfer taxes  applicable to the initial  issuance of
Registrable  Securities  to  each  Holder,  fees  of  any  transfer  agents  and
registrars,  fees and  disbursements of Parent's counsel and independent  public
accountants for

                                      -19-
<PAGE>

Parent,  including  expenses  incurred by Parent in connection  with any special
audits incidental to or required by such  registration.  The term  "Registration
Expenses"  shall  not  include  any  of  the  following,   which  are  sometimes
hereinafter  referred to as "Individual  Holder  Expenses":  underwriting  fees,
discounts  and  expenses,   if  any,  applicable  to  any  Holder's  Registrable
Securities;  fees and disbursements of counsel or other  professionals  that any
Holder may choose to retain in connection with the registration  statement filed
pursuant  to  this  Agreement;  selling  commissions  or  stock  transfer  taxes
applicable to the Registrable Securities registered on behalf of any Holder; any
other  expenses  incurred by or on behalf of such Holder in connection  with the
offer and sale of such Holder's  Registrable  Securities other than Registration
Expenses.

            1.13  "Securities  Act" shall mean the  Securities  Act of 1933,  as
amended,  or any similar federal statute  enacted  hereafter,  and the rules and
regulations  of the  Commission  thereunder,  all as the same shall be in effect
from time to time.

      2. Registration.  On or prior to the Filing Date, Parent shall prepare and
file with the Commission a registration statement on Form SB-2 (or, if such form
is unavailable  for such a  registration,  on such other form as is available to
Parent for such a  registration),  covering the resale of all of the Registrable
Securities.  Parent shall use its commercially  reasonable best efforts to cause
the Registration  Statement to be declared effective under the Securities Act as
promptly as  practicable  on or after the 180th day following the Effective Date
of the Merger. Parent shall use its commercially reasonable best efforts to keep
the  Registration  Statement  continuously  effective  under the  Securities Act
during  the  period  from the  Effective  Date of the  Merger  until  the  first
anniversary of the Effective Date of the Merger (the "Effective Period").

      3. Registration Procedures; Condition to Parent's Obligations.

            3.1  Parent  will keep each  Holder  advised  in  writing  as to the
initiation of the  Registration  Statement and as to the completion  thereof and
will, at its expense:

                  (a) use its commercially  reasonable best efforts to keep such
registration effective for the Effective Period;

                  (b) Prepare and file with the Commission  such  amendments and
supplements to the Registration Statement and the Prospectus as may be necessary
to  comply  with  the  provisions  of the  Securities  Act with  respect  to the
disposition of all securities covered by such Registration Statement;

                  (c) Furnish such number of  Prospectuses  and other  documents
incident thereto, including any amendment of or supplement to the Prospectus, as
a Holder from time to time may  reasonably  request,  but only while the Company
shall  be  required  under  the  provisions  hereof  to cause  the  registration
statement to remain current;

                  (d) Notify each Holder of  Registrable  Securities  covered by
the  Registration  Statement at any time when a Prospectus  relating  thereto is
required to be delivered  under the Securities Act of the happening of any event
as a result of which the Prospectus included in such Registration  Statement, as
then in effect,  includes  an untrue  statement  of a material  fact or omits to
state a material  fact  required to be stated  therein or  necessary to make the
statements  therein  not  misleading  in the  light  of the  circumstances  then
existing,  and at the  request of any such  Holder,  prepare and furnish to such
Holder a reasonable  number of copies of a supplement to or an amendment of such
Prospectus  as  may  be  necessary  so  that,  as  thereafter  delivered  to the
purchasers of such shares, such Prospectus shall not include an untrue statement
of a  material  fact or omit to state a  material  fact  required  to be  stated
therein or necessary to make the statements  therein not misleading in the light
of the circumstances then existing;

                                      -20-
<PAGE>

                  (e) Use its best efforts to cause all  Registrable  Securities
covered by such Registration Statement to be registered with or approved by such
other federal or state governmental  agencies or authorities as may be necessary
in the opinion of counsel to Parent and  counsel to the  Holders of  Registrable
Securities to enable the Holders  thereof to consummate the  disposition of such
Registrable Securities (provided, however, that Parent shall not be obligated to
qualify  as a  foreign  corporation  to  do  business  under  the  laws  of  any
jurisdiction  in  which  it is  not  then  qualified),  and  maintain  any  such
registration  or  qualification  current  until the  earlier  of the sale of the
Registrable  Securities so  registered or until the  expiration of the Effective
Period;

                  (f) List all such  Registrable  Securities  registered in such
registration on each securities  exchange or automated quotation system on which
the Common Stock of Parent is then listed;

                  (g) Provide a transfer agent and registrar for all Registrable
Securities and a CUSIP number for all such Registrable Securities,  in each case
not later than the effective date of such registration;

                  (h) Prior to filing the  registration  statement  covering the
Registrable  Securities,  make  available for  inspection at Parent's  corporate
office  in  New  York,  New  York  upon  reasonable  request  by any  Holder  of
Registrable Securities, any attorney,  accountant or other agent retained by any
of the Holders,  during normal business hours of Parent and without unreasonable
disruption of Parent's business or unreasonable expense to Parent and solely for
the purpose of due diligence  with respect to the  registration  statement,  all
publicly  available,  non-confidential  financial and other  records,  including
without limitation  pertinent  corporate documents of Parent, and cause Parent's
officers,  directors and employees to supply, at the requesting  parties expense
and without unreasonable disruption of Parent's business or unreasonable expense
to parent and  solely  for the  purpose  of due  diligence  with  respect to the
registration  statement,  all publicly available,  non-confidential  information
reasonably  requested by the  attorney,  accountant or other agent of any of the
Holders;

            3.2 It shall be a condition  precedent to the  obligations of Parent
to take any action  pursuant to this  Agreement  that each of the Holders  whose
Registrable  Securities are to be registered  pursuant to this  Agreement  shall
furnish  the  following  to  Parent  prior  to  performance  by  Parent  of  its
obligations under this Agreement:

                  (a) written evidence reasonably satisfactory to Parent of each
such Holder's agreement to be bound by this Agreement;

                                      -21-
<PAGE>

                  (b)  information  regarding each such Holder,  the Registrable
Securities held by such Holder,  and any additional  information as Parent shall
reasonably  request and as shall be required in connection with the action to be
taken by Parent;

                  (c) written evidence reasonably satisfactory to Parent of each
such  Holder's  agreement  to provide  customary  indemnifications  to Parent in
respect of information furnished by or on behalf of each Holder or actions taken
or omitted by each Holder (as consistent with the indemnification  provisions of
this  Agreement),  and to pay the Individual  Holder Expenses  incurred by or on
behalf of each Holder which are not Registration Expenses required to be paid by
Parent  hereunder,  and to customary  blackout  periods in the event of material
corporate developments affecting Parent or its securities; and

                  (d) written evidence reasonably satisfactory to Parent of each
Holder's  agreement  that  upon  receipt  of any  written  notice  by  Parent to
discontinue  use of the  registration  statement  or any  prospectus  or related
document until the same are supplemented or amended, that Holder will so refrain
and,  if so directed by Parent,  will  deliver to Parent all copies,  other than
permanent file copies, then in Holder's possession of such documents at the time
of receipt of such  notice.  Furthermore,  each Holder  shall agree that if such
Holder uses a prospectus in connection  with the offering and sale of any of the
Registrable  Securities,  the Holder  will use only the  latest  version of such
prospectus provided by Parent.

      4. Expenses.  All  Registration  Expenses  incurred in connection with any
registration,  qualification or compliance  pursuant to Sections 2 and 3 of this
Agreement shall be borne by Parent.

      5. Indemnification.

            5.1  Indemnification by Parent. To the full extent permitted by law,
Parent  will  indemnify  each  Holder,  each  of  its  officers,  directors  and
employees,  and each  person  controlling  a Holder  within  the  meaning of the
Securities Act, with respect to which registration,  qualification or compliance
has been effected pursuant to this Agreement against all claims, losses, damages
and  liabilities  (or actions,  proceedings or  settlements in respect  thereof)
arising out of or based on any untrue statement (or alleged untrue statement) of
a material fact contained in any prospectus, offering circular or other document
(including  any  related  registration  statement,  notification  or  the  like)
incident to any such registration,  qualification or compliance, or based on any
omission (or alleged  omission) to state  therein a material fact required to be
stated therein or necessary to make the statements  therein not  misleading,  or
any  violation  by  Parent  of the  Securities  Act or any  rule  or  regulation
thereunder  applicable to Parent and relating to action or inaction  required of
Parent in connection with any such  registration,  qualification  or compliance,
and will  reimburse  each  such  Holder,  each of its  officers,  directors  and
partners,  and each person  controlling  such Holder for any legal and any other
expenses  reasonably  incurred in connection with investigating and defending or
settling any such claim, loss, damage, liability or action, provided that Parent
will not be liable in any such case to the  extent  that any such  claim,  loss,
damage,  liability or expense arises out of or is based on any untrue  statement
or omission made in reliance upon and based upon written  information  furnished
to Parent by or on behalf of such Holder for use therein.

                                      -22-
<PAGE>

            5.2 Indemnification by the Holders.  Each Holder will, to the extent
Registrable  Securities  held  by  him or it are  included  in the  Registration
Statement,  indemnify Parent, each of its directors,  officers and employees and
each other  person,  if any,  who  controls  Parent  within  the  meaning of the
Securities Act, against all claims,  losses,  damages,  expenses and liabilities
(or actions in respect  thereof) arising out of or based on any untrue statement
(or  alleged  untrue  statement)  of a  material  fact  contained  in  any  such
Registration Statement,  Prospectus, offering circular or other document, or any
omission (or alleged  omission) to state  therein a material fact required to be
stated therein or necessary to make the statements  therein not  misleading,  or
any  violation by such Holder of the  Securities  Act or any rule or  regulation
thereunder applicable to such Holder and relating to action or inaction required
of such  Holder  in  connection  with any such  registration,  qualification  or
compliance,  and will  reimburse  Parent,  each of its  directors,  officers and
employees and each other person for any legal or any other  expenses  reasonably
incurred in connection  with  investigating  or defending any such claim,  loss,
damage,  liability  or action,  in each case with respect to any such alleged or
actual  untrue  statement  of a material  fact or alleged or actual  omission to
state a material  fact to the extent,  but only to the extent,  that such untrue
statement (or alleged  untrue  statement)  or omission (or alleged  omission) is
made in such  Registration  Statement,  Prospectus,  offering  circular or other
document in reliance upon and in conformity with written  information  furnished
to Parent by such Holder for use therein.

            5.3  Notices of Claims,  Procedures,  etc.  Each party  entitled  to
indemnification under this Section 5 (the "Indemnified Party") shall give notice
to the party  required to provide  indemnification  (the  "Indemnifying  Party")
promptly after such  Indemnified  Party has actual  knowledge of any claim as to
which indemnity may be sought, and shall permit the Indemnifying Party to assume
the defense of any such claim or any litigation  resulting  therefrom,  provided
that the  Indemnified  Party may  participate in such defense at the Indemnified
Party's sole expense,  and provided  further that the failure of any Indemnified
Party to give notice as provided herein shall not relieve the Indemnifying Party
of its  obligations  under this Section 5 unless such failure is  prejudicial to
the   ability   of   Indemnifying   Party  to  defend   such  claim  or  action.
Notwithstanding  the foregoing,  such Indemnified  Party shall have the right to
employ its own counsel in any such litigation, proceeding or other action if (i)
the employment of such counsel has been authorized by the Indemnifying Party, in
its sole and absolute  discretion,  or (ii) the named parties in any such claims
(including any impleaded  parties)  include any such  Indemnified  Party and the
Indemnified Party and the Indemnifying  Party shall have been advised in writing
(in suitable  detail) by counsel to the Indemnified  Party either (A) that there
may be one or more legal defenses  available to such Indemnified Party which are
different from or additional to those  available to the  Indemnifying  Party, or
(B) that there is a conflict of interest by virtue of the Indemnified  Party and
the  Indemnifying  Parties having common  counsel,  in any of which events,  the
reasonable  legal fees and  expenses  of a single  counsel  for all  Indemnified
Parties  with  respect to each such claim,  defense  thereof,  or  counterclaims
thereto shall be borne by  Indemnifying  Party.  No  Indemnifying  Party, in the
defense of any such claim or litigation,  shall, except with the consent of each
Indemnified Party, which consent shall not be unreasonably withheld,  consent to
entry of any judgment or enter into any settlement  which does not include as an
unconditional  term  thereof  the giving by the  claimant or  plaintiff  to such
Indemnified  Party of a release  from all  liability in respect to such claim or
litigation.  Each  Indemnified  Party shall  cooperate to the extent  reasonably
required and furnish such information  regarding itself or the claim in question
as an  Indemnifying  Party may  reasonably  request in  writing  and as shall be
reasonably  required in  connection  with  defense of such claim and  litigation
resulting therefrom.

                                      -23-
<PAGE>

            5.4  Contribution.  If the  indemnification  provided  for  in  this
Section  5 shall  for any  reason  be held by a court to be  unenforceable  as a
matter of public policy with respect to an  Indemnified  Party in respect of any
loss,  claim,  damage,  expense or liability,  or any action in respect thereof,
then,  in lieu of the amount paid or payable  under  Section 5.1 or Section 5.2,
the Indemnified  Party and the  Indemnifying  Party under Section 5.1 or Section
5.2 shall  contribute to the aggregate  losses,  claims,  damages,  expenses and
liabilities (including legal or other expenses reasonably incurred in connection
with  investigating  the same),  (a) in such  proportion  as is  appropriate  to
reflect the  relative  fault of the  Indemnified  Party and  Indemnifying  Party
covered by the  registration  statement  which  resulted  in such  loss,  claim,
damage,  expense or liability,  or action or proceeding in respect thereof, with
respect to the  statements  or  omissions  which  resulted in such loss,  claim,
damage,  expense or liability,  or action or proceeding in respect  thereof,  as
well as any other  relevant  equitable  considerations  or (b) if the allocation
provided  by clause  (a)  above is not  permitted  by  applicable  law,  in such
proportion as shall be appropriate to reflect the relative  benefits received by
the Indemnified Party and Indemnifying Party from the offering of the securities
covered by such  registration  statement;  provided,  that for  purposes of this
clause (b), the relative benefits  received by the prospective  sellers shall be
deemed  not to  exceed  the  amount of  proceeds  received  by such  prospective
sellers. No person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution  from any
person who was not guilty of such fraudulent misrepresentation. Such prospective
sellers'  obligations  to contribute as provided in this Section 5.4 are several
in proportion to the relative value of their respective  Registrable  Securities
covered by such  registration  statement and not joint.  In addition,  no person
shall be  obligated  to  contribute  hereunder  any  amounts in payment  for any
settlement of any action or claim effected without such person's consent,  which
consent shall not be unreasonably withheld.

      6. [INTENTIONALLY OMITTED]

      7.  Exchange  Act  Compliance.  While  Parent is subject to the  reporting
requirements of the Exchange Act, Parent shall make commercially reasonable best
efforts to file the reports  required to be filed by it under the Securities Act
and the Exchange  Act and the rules and  regulations  adopted by the  Commission
thereunder,  and to take all actions  reasonably  necessary to enable Holders of
Registrable  Securities to sell such securities  without  registration under the
Securities Act within the limitation of the provisions of (a) Rule 144 under the
Securities  Act,  as such Rule may be amended  from time to time,  (b) Rule 144A
under the  Securities  Act,  as such Rule may be amended  from time to time,  if
applicable  or (c) any similar  rules or  regulations  hereunder  adopted by the
Commission.  Upon the request of any Holder of  Registrable  Securities,  Parent
will  deliver to such holder a written  statement  as to whether it has complied
with such requirements.

      8. Specific Performance.  The parties hereto acknowledge that there may be
no adequate  remedy at law if any party fails to perform any of its  obligations
hereunder and that each party may be irreparably harmed by any such failure, and
accordingly  agree that each party,  in addition to any other remedy to which it
may be  entitled  at law or in  equity,  shall  be  entitled  to seek to  compel
specific  performance of the obligations of any other party under this Agreement
in accordance with the terms and conditions of this Agreement.

                                      -24-
<PAGE>

      9. No Registration  Conflict.  Parent has not previously  entered into any
agreement granting any registration rights with respect to any of its securities
to any Person that has not been fully satisfied other than  registration  rights
granted in connection with warrants issued to  Bioaccelerate,  Inc. Parent shall
not after the date hereof enter into any agreement granting  registration rights
with respect to any of its securities outstanding on the date hereof, except (i)
pursuant to the Merger Agreement, (ii) registration rights for Parent's existing
shareholders  who do not have  freely  tradable  shares  on the date  hereof  as
contemplated  by  Section  2.1(j) of the  Merger  Agreement,  or (iii) as may be
determined  by Parent's  Board of Directors  (as  constituted  subsequent to the
Merger) in the exercise of their fiduciary responsibilities.

      10.  Benefits of Agreement;  Successors and Assigns.  This Agreement shall
inure to the benefit of and be binding upon the successors and permitted assigns
of each of the  parties  and shall  inure to the benefit of each Holder and each
Holder  shall be an  intended  third  party  beneficiary  under this  Agreement.
Neither Parent nor any Holder may assign its rights or obligations hereunder.

      11.   Complete   Agreement.   This  Agreement   constitutes  the  complete
understanding  among  the  parties  with  respect  to  its  subject  matter  and
supersedes all existing agreements and understandings,  whether oral or written,
among them. No alteration or  modification  of any  provisions of this Agreement
shall be valid  unless  made in  writing  and  signed,  on the one hand,  by the
Holders of a majority of the Registrable Securities then outstanding and, on the
other, by Parent.

      12. Section Headings. The section headings contained in this Agreement are
for  reference  purposes  only and shall not  affect in any way the  meaning  or
interpretation of this Agreement.

      13. Notices.  All notices,  offers,  acceptances and other  communications
required or  permitted  to be given or to otherwise be made to any party to this
Agreement shall be deemed to be sufficient if contained in a written  instrument
delivered by hand,  first class mail  (registered  or certified,  return receipt
requested),  telex,  telecopier or overnight air courier  guaranteeing  next day
delivery,  if to  Parent,  at 712  Fifth  Avenue,  New York,  New  York,  10019,
Attention:  Andrew J.  Cosentino,  and if to any Holder,  at the address of such
Holder as set forth in the stock transfer books of Parent.  All such notices and
communications shall be deemed to have been duly given: at the time delivered by
hand, if personally  delivered;  five business days after being deposited in the
United  States  mail,  First Class  postage  prepaid,  if mailed;  when  receipt
acknowledged, if telecopied (or on the next succeeding business day if such date
is not a business  day; and the next  business day after timely  delivery to the
courier,  if sent by overnight air courier  guaranteeing next day delivery.  For
purposes of this  paragraph,  a "business day" shall mean any day which is not a
Saturday,  Sunday,  or public  holiday  or a day on which  commercial  banks are
required  or  authorized  by law to close in New York,  New York.  Any party may
change the address to which each such notice or  communication  shall be sent by
giving  written  notice to tie other  parties of such new  address in the manner
provided herein for giving notice.

                                      -25-
<PAGE>

      14.  Governing Law. This Agreement shall be governed by, and construed and
enforced in accordance  with,  the laws of the State of Delaware  without giving
effect to the provisions,  policies or principles thereof respecting conflict or
choice of laws.

      15.  Counterparts.   This  Agreement  may  be  executed  in  one  or  more
counterparts  each of which shall be deemed an  original  but all of which taken
together  shall  constitute  one and the same  agreement.  A facsimile copy of a
signature page shall be deemed to be an original signature page.

      16. Severability.  If any term, provision, covenant or restriction of this
Agreement is held by a court of competent  jurisdiction to be invalid,  illegal,
void or  unenforceable,  the remainder of the terms,  provisions,  covenants and
restrictions set forth herein shall remain in full force and effect and shall in
no way be affected,  impaired or  invalidated,  and the parties hereto shall use
their reasonable best efforts to find and employ an alternative means to achieve
the same or  substantially  the same result as that  contemplated  by such term,
provision,  covenant or restriction.  It is hereby stipulated and declared to be
the intention of the parties that they would have executed the remaining  terms,
provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

                  [Remainder of page intentionally left blank.]

                                      -26-
<PAGE>

      IN WITNESS WHEREOF,  the parties have signed this Agreement as of the date
first set forth above.

                                        ENHANCE BIOTECH, INC.

                                        By  /s/  Christopher Every
                                           --------------------------------
                                              Name:  Christopher Every
                                              Title:    President and CEO

                                        ARDENT ACQUISITION CORP.

                                        By  /s/  Christopher Every
                                           --------------------------------
                                              Name:  Christopher Every
                                              Title:    President and CEO

                                        ARDENT PHARMACEUTICALS, INC.

                                        By  /s/  Kwen-Jen Chang
                                           --------------------------------
                                             Name:  Kwen-Jen Chang
                                             Title:    President and CEO

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00076-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00076-of-00352.parquet"}]]