Document:

Exhibit 10.39

                                 LEASE AMENDMENT

DATED:  MARCH  3,  2003

BETWEEN:  PACIFIC  REALTY  ASSOCIATES,  L.P.,
          a  Delaware  limited  partnership                             LANDLORD

AND:      EXELIXIS  PLANT  SCIENCES,  INC.,
          a wholly  owned  subsidiary  of  Exelixis,  Inc.,
          a  Delaware  corporation                                        TENANT

          Pacific  Realty  Associates,  L.P., a Delaware limited partnership, as
Landlord,  and American Show Management, Inc. as Original Tenant, entered into a
written  lease  dated October 4, 1995, consisting of approximately 11,059 square
feet  of  office  and  warehouse  space located in Building C, PacTrust Business
Center,  16160  S.W.  Upper  Boones Ferry Road, Portland, Oregon 97224. By Lease
Amendment  dated  June  3,  1996,  the  Lease  was  amended.  By  Assignment and
Modification  of  Lease,  dated  November  7, 1997, Original Tenant assigned the
Lease  to  Agritope,  Inc. By Lease Amendment dated September 9, 1999, Agritope,
Inc.  leased  an  additional  approximately  6,801  square  feet  of  office and
warehouse  space.  Agritope,  Inc.'s leased area now totals approximately 17,860
total  square feet of office and warehouse space (hereinafter referred to as the
"Premises").  By  facsimile  dated  November  5,  2002,  Agritope, Inc. notified
Landlord that it had been acquired by Exelixis, Inc. effective December 8, 2000,
and changed its name to Exelixis Plant Sciences, Inc., a wholly owned subsidiary
of  Exelixis,  Inc.  (hereinafter  referred  to as "Tenant"). Such documents are
hereinafter  jointly  referred to as "the Lease." The Lease expires February 28,
2003.

          Tenant  now  wishes  to  extend  the  term  of  the  Lease.

          NOW,  THEREFORE,  the  parties  agree  as  follows:

     1.  The  term  of  the Lease shall be extended for an additional thirty-six
(36)  months  commencing March 1, 2003 and continuing through February 28, 2006.

     2.  Commencing  March  1,  2003  and  continuing through the extended term,
Tenant  shall  pay  base  rent  according  to  the  following  schedule:

<TABLE>
<CAPTION>
                                         BASE RENT
PERIOD                                   PER MONTH
---------------------------------------  ----------
<S>                                      <C>

March 1, 2003 through February 29, 2004  $16,610.00
---------------------------------------  ----------
March 1, 2004 through February 28, 2005  $17,146.00
---------------------------------------  ----------
March 1, 2005 through February 28, 2006  $17,681.00
---------------------------------------  ----------
</TABLE>

     3. Except as expressly modified hereby, all terms of the Lease shall remain
in  full  force  and  effect  and  shall  continue  through  the  extended term.

<PAGE>
          IN  WITNESS  WHEREOF,  the  parties  hereto  have  executed  this
Agreement  on the respective dates set opposite their signatures below, but this
Agreement  on  behalf of such party shall be deemed to have been dated as of the
date  first  above  written.

                                   LANDLORD:

                                   PACIFIC  REALTY  ASSOCIATES,  L.P.,
                                   a  Delaware  limited  partnership

                                   By:  PacTrust  Realty,  Inc.,
                                        a  Delaware  corporation,
                                        its  General  Partner

Date:  November  14,  2002              By:  /s/  Sam  K. Briggs
                                             Sam  K.  Briggs
                                             Vice  President

                                   TENANT:

                                   EXELIXIS  PLANT  SCIENCES,  INC.,
                                   a  wholly owned subsidiary of Exelixis, Inc.,
                                   a  Delaware  corporation

Date:  November 14, 2002           By:  /s/ Matthew G. Kramer
                                   Name:  Matthew G. Kramer
                                   Title: General ManagerExhibit 10.40

January  4,  2002

Dear  Bob:

We are proud to invite you to join our team.

Our offer of employment is to join Exelixis, Inc. as Executive Vice President of
Pharmaceuticals  reporting  directly  to  me.

Other  terms  of  employment  include:

Compensation:  Your  initial  bi-monthly  salary  will be thirteen thousand five
hundred  forty  one  dollars and sixty-six cents ($13,541.66). Additionally, you
will  receive  a  sign-on  bonus of fifty thousand dollars ($50,000) payable the
first  pay date after hire. Should you elect to voluntarily terminate employment
with  the Company within twelve (12) months of your hire date, the sign-on bonus
will  be entirely re-paid by you to the Company.  This re-payment of the sign-on
bonus  shall  occur  within  thirty  (30)  days  of  termination.

Loan:   We  will  make  available  a  loan to you in an amount up to two hundred
thousand dollars ($200,000.00).  The loan will have a term of four (4) years and
bear  interest at the lowest rate available for a loan of this term in effect as
of  the  date  of the loan published under the rules and regulations of the U.S.
Treasury.  Interest  will accrue and be payable annually within five (5) days of
each anniversary date.  The principal on the loan will be subject to forgiveness
as  follows:  (a)  fifty  percent of the outstanding loan balance or one hundred
thousand  dollars  ($100,000)  upon  your  second  anniversary  of  full-time
employment;  and  (b)  twenty  five percent of the initial loan balance or fifty
thousand  dollars ($50,000) upon your third anniversary of full-time employment;
and  (c)  the remaining twenty five percent of the initial loan balance or fifty
thousand  dollars  ($50,000)  on your fourth anniversary of full-time employment
provided  that  the loan has not otherwise been repaid or required to be repaid.
All unpaid and unforgiven portions of the principal will be subject to repayment
prior  to  maturity  upon  termination  of  your employment prior to your fourth
anniversary  date.  All  forgiven  amounts  will  be  subject to withholding and
reported  on  your  Form  W-2  in  the  year  of  forgiveness.

Performance  Review:  Your  performance  will  be formally reviewed no less than
annually  you  will  be  eligible  to receive an incentive bonus of up to thirty
percent  (35%)  of  your  annual  salary based on achievement of key milestones.

Benefits:  All  full-time  employees of Exelixis, Inc. enjoy a generous benefits
package  as  is  outlined  on  the  attached  Summary  of  Benefits.

Review:  Your  performance  will  be  formally  reviewed  no less than annually.

Confidentiality:  As  you  are aware, it is very important for us to protect our
confidential information and proprietary material.  Therefore, as a condition of
employment,  you  will  need  to  sign  the attached Proprietary Information and
Inventions  Agreement.

Start  Date:  January  22,  2002.

Options  for  Equity:  You will also be eligible to receive a stock option grant
for two hundred twenty five thousand (225,000) shares of Exelixis stock pursuant
to  our 2000 Equity Incentive Plan pursuant to the standard form of stock option
agreement  at  the  closing price on your start date, subject to approval by the
Board  of  Directors.  Shares subject to options vest at the rate of 1/4th after
one  year  of  employment and 1/48th every month thereafter over a total of four
years.

Termination:  In  the  event  of  termination  of your employment by the Company
without  Cause,  the  Company  will  continue  to pay you your base salary for a
period after the date of such termination equal to six months.  In addition, you
will  be  entitled  to receive the amount of any declared but unpaid bonus as at
the date of such termination and the Company shall continue to make available to
you  such  fringe  benefits  as  required  by  law.

Other:   In  addition  to  performing  the  duties  and responsibilities of your
position, you will be expected to perform other duties and responsibilities that
may  be assigned to you from time to time.  No provision of this letter shall be
construed  to  create  an  express or implied employment contract for a specific
period  of  time.  Either  you  or  the  Company  may  terminate this employment
relationship  at any time, with or without cause.  This letter shall be governed
by  the  laws of the State of California.  Also, by signing this letter, you are
indicating  that  you  are  legally  authorized  to  work  in  the  U.S.

<PAGE>
You  may  accept  this offer of employment by signing both copies of this letter
and  Proprietary  Information and Invention Agreements and returning one of each
to  me.

Bob,  we  look  forward  to  your  coming  on  board!

Sincerely,

/s/  George  Scangos

George  Scangos,  Ph.D.
President  and  CEO

ACCEPTED  BY:

/s/  Bob  Myers                     15th  Jan  2002
----------------------------        ---------------
Robert  Myers

ENCLOSURES:

Benefit  Summary              Direct  Deposit  Form  (optional)
Confidentiality  Agreement    Employee  Information  Form
DE-4  (optional)              I-9
Insider  Trading  Policy      W-4Exhibit 10.31
                           THIRD AMENDMENT AGREEMENT

<PAGE>

                                                                   EXHIBIT 10.31
                                                                   -------------
                            THIRD AMENDMENT AGREEMENT
                            -------------------------

         THIRD AMENDMENT AGREEMENT (this "AGREEMENT") dated as of March 5, 2003
by and among (1) Imagistics International Inc. (the "BORROWER"), (2) Fleet
Capital Corporation ("FLEET"), and the other financial institutions party to the
Credit Agreement (as defined below) as lenders (collectively, the "LENDERS" and
individually, a "LENDER") and (3) Fleet, as administrative agent (the
"ADMINISTRATIVE AGENT") for the Lenders with respect to a certain Credit
Agreement dated as of November 9, 2001 by and among the Borrower, the Lenders
and the Administrative Agent, as amended by that certain First Amendment
Agreement dated as of March 19, 2002 and that certain Second Amendment Agreement
dated as of July 19, 2002 (as amended, the "CREDIT AGREEMENT").

                              W I T N E S S E T H:

         WHEREAS, the Borrower has requested that the Lenders amend certain
terms and conditions of the Credit Agreement on the terms and conditions set
forth herein; and

         WHEREAS, the parties hereto have agreed to amend certain provisions of
the Credit Agreement.

         NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto agree as
follows:

         1.    DEFINITIONS. Capitalized terms used herein without definition
that are defined in the Credit Agreement (after giving effect to the amendments
thereof set forth herein) shall have the same meanings herein as therein.

         2.    RATIFICATION OF EXISTING AGREEMENTS. All of the Borrower's
obligations and liabilities to the Creditors as evidenced by or otherwise
arising under the Credit Agreement, the Notes and the other Credit Documents,
are, by the Borrower's execution of this Agreement, ratified and confirmed in
all respects. In addition, by the Borrower's execution of this Agreement, the
Borrower represents and warrants that it does not have any counterclaim, right
of set-off or defense of any kind with respect to such obligations and
liabilities.

         3.    REPRESENTATIONS AND WARRANTIES. The Borrower hereby represents
and warrants to the Creditors that all of the representations and warranties
made by the Borrower in the Credit Agreement, the Notes and the other Credit
Documents are true in all material respects on the date hereof as if made on and
as of the date hereof, except to the extent that such representations and
warranties relate expressly to an earlier date.

         4.    CONDITIONS PRECEDENT. The effectiveness of the amendments
contemplated hereby shall be subject to the satisfaction on or before the date
hereof of each of the following conditions precedent:

<PAGE>

                 (a) Representations and Warranties. All of the representations
         and warranties made by the Borrower herein, whether directly or
         incorporated by reference, shall be true and correct on the date hereof
         except as provided in ss.3 hereof.

                 (b) Performance; No Event of Default. The Borrower shall have
         performed and complied in all respects with all terms and conditions
         herein required to be performed or complied with by it prior to or at
         the time hereof, and there shall exist no Default or Event of Default.

                 (c) Corporate Action. All requisite corporate action necessary
         for the valid execution, delivery and performance by the Borrower of
         this Agreement and all other instruments and documents delivered by the
         Borrower in connection therewith shall have been duly and effectively
         taken.

                 (d) Delivery. The parties hereto shall have executed this
         Agreement and delivered this Agreement to the Agent.

5.       AMENDMENTS TO THE CREDIT AGREEMENT.
         ----------------------------------

         5.1   AMENDMENTS TO SECTION 1.01.

         (a)   The following definition appearing in Section 1.01 of the Credit
         Agreement is hereby amended in its entirety to read as follows:

                       "Permitted Repurchase Amount" shall mean an amount equal
               to the sum of (a) $78,000,000, plus (b) the amount of net cash
               proceeds actually received by the Borrower from the issuance
               and/or resale by the Borrower of up to 1,000,000 shares of its
               common stock Equity Interests to its employees pursuant to the
               Borrower's employee stock purchase plan.

         (b)   The following new definition is hereby added to Section 1.01 of
         the Credit Agreement in its proper alphabetical order to read as
         follows:

                       "Borrowing Base Availability" shall mean, as at any date,
               an amount equal to the result of (a) the Borrowing Base, minus
               (b) the sum of (i) the aggregate amount of Revolving Loans then
               outstanding, plus (ii) the aggregate amount of Swing Loans then
               outstanding, plus (iii) the Dollar Equivalent of the aggregate
               L/C Liabilities then outstanding, less (iv) the amount of any L/C
               cover that shall have been provided pursuant to Section 2.10(d)
               and not yet returned.

  5.2    AMENDMENT TO SECTION 9.01.  Subsection 9.01(j) of the Credit Agreement
is hereby amended in its entirety to read as follows:

                                       2

<PAGE>

        (j)    BORROWING BASE CERTIFICATE. As soon as available and in any event
               within 30 days after the end of each quarterly fiscal period
               (ending on the last day of each calendar quarter) beginning with
               the quarterly period ending March 31, 2003, a Borrowing Base
               Certificate as of the last day of such accounting period;
               provided, that if the most recent Borrowing Base Certificate
               provided by the Borrower evidences Borrowing Base Availability
               equal to or less than $50,000,000, thereafter Borrower shall be
               required to deliver a Borrowing Base Certificate as soon as
               available and in any event within 30 days after the end of each
               monthly accounting period (ending on the last day of each
               calendar month); provided, further, that if Borrower fails to
               deliver any such Borrowing Base Certificate when due, then the
               Borrowing Base shall be deemed to be $0 (provided, however, that
               no prepayment shall be required pursuant to Section 2.10(c)
               solely by reason of such deemed reduction) until such time as
               Borrower shall deliver such required Borrowing Base Certificate;
               Borrower shall notify Administrative Agent promptly upon becoming
               aware of any event or condition that could reasonably be expected
               to have a material adverse effect on the Borrowing Base;

               5.3  AMENDMENT TO SECTION 9.11(b).  Subsection 9.11(b) of the
         Credit Agreement is hereby amended in its entirety to read as follows:

                   (b) Minimum Consolidated EBITDA. Consolidated EBITDA
shall not for the previous four consecutive fiscal quarters most recently ended
as of any Test Date occurring on or after December 31, 2002 be less than
$100,000,000.

               5.4  AMENDMENT TO SECTION 9.11(c). Subsection 9.11(c) of the
Credit Agreement is hereby amended in its entirety to read as follows:

                (c)      Limitation on Capital Expenditures. No Company shall,
                         directly or indirectly, permit the aggregate amount of
                         all Capital Expenditures made by the Companies during
                         any period of four consecutive fiscal quarters most
                         recently ended as of any Test Date occurring on or
                         after December 31, 2002 to exceed 85% of Consolidated
                         EBITDA for such period.

6.       MISCELLANEOUS PROVISIONS.

                (a) Except as otherwise expressly provided by this Agreement,
all of the respective terms, conditions and provisions of the Credit Agreement,
the Notes and the other Credit Documents shall remain the same. The Credit
Agreement, the Notes and the other Credit Documents, each as amended hereby,
shall continue in full force and effect, and that this Agreement and the Credit
Agreement shall be read and construed as one instrument.

                (b) This Agreement is intended to take effect under, and shall
be construed according to and governed by, the laws of the State of New York.

                (c) This Agreement may be executed in any number of
counterparts, but all such counterparts shall together constitute but one
instrument. In making proof of this Agreement it shall not be necessary to
produce or account for more than one counterpart signed by each party

                                       3

<PAGE>

hereto by and against which enforcement hereof is sought. A facsimile of an
executed counterpart shall have the same effect as the original executed
counterpart.

         [REMAINDER OF PAGE INTENTIONALLY BLANK; SIGNATURE PAGES FOLLOW]

                                       4
<PAGE>

         IN WITNESS WHEREOF, each of the parties hereto have caused this
Agreement to be executed in its name and behalf by its duly authorized officer
as of the date first written above.

                            IMAGISTICS INTERNATIONAL INC.

                            By:   /s/ Joseph  Skrzypczak
                                  ----------------------
                                  Joseph D. Skrzypczak
                                  Its:  Chief Financial Officer

                            FLEET CAPITAL CORPORATION,
                             as Administrative Agent and as a Lender

                            By:  /s/ Edgar Ezerins
                                 -----------------
                                 Edgar Ezerins
                                 Its: Vice President

                            MERRILL LYNCH CAPITAL CORPORATION,
                             as a Lender

                            By:  /s/ Michael E. O'Brien
                                 ----------------------
                                 Michael E. O'Brien
                                 Its: Vice President

                            NATEXIS BANQUE POPULAIRES
                             as a Lender

                            By:   /s/ William J. Burke
                                  --------------------
                                  William J. Burke
                                  Its:  Vice President

                            By:  /s/ Michael J. Storms
                                 ---------------------
                                 Michael J. Storms
                                 Its:  Associate

<PAGE>

                            JPMORGAN CHASE BANK,
                             as a Lender

                            By:  /s/ Valerie Schanzer
                                 --------------------
                                 Valerie Schanzer
                                 Its:  Vice President

                            THE INDUSTRIAL BANK OF JAPAN, LIMITED,
                             as a Lender

                            By:____________________________

                                 Its:

                            IBM CREDIT CORPORATION,
                              as a Lender

                            By:____________________________

                                 Its:

                            PEOPLE'S BANK,
                             as a Lender

                            By: /s/ David K. Sherrill
                                ---------------------
                                David K. Sherrill
                                Its:  Vice President

                            BANK LEUMI, USA,
                            as a Lender

                            By: /s/ Paul Tine
                                -------------
                                Paul Tine
                                Its: Vice President

                            By: /s/ Glenn Kreutzer
                                ------------------
                                Glenn Kreutzer
                                Its: Banking Officer

                  [Signature page to Third Amendment Agreement]
<PAGE>

                            GENERAL ELECTRIC CAPITAL CORPORATION,
                            as a Lender

                            By:____________________________

                                  Its:

                            U.S. BANK NATIONAL ASSOCIATION,
                            as a Lender

                            By: /s/ Joseph Howard
                                -----------------
                                Joseph Howard
                                Its:  Vice President

                            CITIZENS BANK OF MASSACHUSETTS,
                            as a Lender

                            By: /s/ Cindy Chen
                                --------------
                                Cindy Chen
                                Its:  Vice President

                            TORONTO DOMINION (NEW YORK), INC.,
                            as a Lender

                            By:____________________________

                                 Its:

                            STANWICH LOAN FUNDING LLC,
                            as a Lender

                            By:____________________________

                                 Its:

                      [Signature page to Third Amendment Agreement]
<PAGE>

                            FRANKLIN FLOATING RATE TRUST,
                            as a Lender

                            By:____________________________

                                 Its:

                            FRANKLIN FLOATING RATE MASTER SERIES,
                            as a Lender

                            By:____________________________

                                 Its:

                            FRANKLIN CLO I, LIMITED,
                            as a Lender

                            By:____________________________

                                 Its:

                            FRANKLIN CLO II, LIMITED,
                            as a Lender

                            By:____________________________

                                 Its:

                            FRANKLIN CLO III, LIMITED,
                            as a Lender

                            By:____________________________

                                 Its:

                            FRANKLIN FLOATING RATE DAILY ACCESS FUND,
                            as a Lender

                            By:____________________________

                                 Its:

                  [Signature page to Third Amendment Agreement]

<PAGE>

                            NEW YORK LIFE INSURANCE COMPANY,
                            as a Lender

                            By:____________________________

                                 Its:

                            NEW YORK LIFE INSURANCE AND ANNUITY
                            CORPORATION
                            as a Lender

                            By: New York Life Investment Management, LLC, its
                            Investment Manager

                            By:____________________________

                                 Its:

                            ELF FUNDING TRUST III,
                            as a Lender

                            By: New York Life Investment Management, LLC as
                            attorney-in-fact

                            By:____________________________

                                 Its:

                           CALIFORNIA PUBLIC EMPLOYEES RETIREMENT
                           SYSTEM,
                           as a Lender

                           By: Highland Capital Management, L.P., as Authorized
                           Representatives of the Board

                           By:____________________________

                                Its:

                  [Signature page to Third Amendment Agreement]

<PAGE>

                            RESTORATION FUNDING CLO, LTD.,
                            as a Lender

                            By: Highland Capital Management, L.P., as Collateral
                            Manager

                            By:____________________________

                                 Its:

                            EMERALD ORCHARD LIMITED,
                            as a Lender

                            By:____________________________

                                 Its:

                            SRV-HIGHLAND, INC.,
                            as a Lender

                            By:____________________________

                                 Its:

                  [Signature page to Third Amendment Agreement]

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