Document:

EX-4.1

 Exhibit 4.1 
  

 
 COMMON STOCK 
COMMON STOCK

Certificate 
PAR VALUE $0.001 
THIS CERTIFICATE IS TRANSFERABLE IN CANTON, MA, JERSEY CITY, NJ AND COLLEGE STATION, TX 
Shares

Number 
ZQ00000000 
ASANTE SOLUTIONS, INC. 
INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE 
* * 000000 * * * * * * * * * * * * * * * * * * 
* * * 000000 * * * * * * * * * * * * * * * * *

* * * * 000000 * * * * * * * * * * * * * * * * 
* * * * * 000000 * * * * * * *
* * * * * * * * 
* * * * * * 000000 * * * * * * * * * * * * * * 
THIS CERTIFIES
THAT 
MR. SAMPLE & MRS. SAMPLE & 
MR. SAMPLE & MRS. SAMPLE

** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample

**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample
**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample 
CUSIP 
04342B 10 4 
**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David 
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander 
SEE REVERSE FOR CERTAIN DEFINITIONS 
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. 
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Sample **** Mr. Sample 
is the owner of 
***ZERO HUNDRED THOUSAND 
ZERO HUNDRED AND ZERO*** 
**000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares
****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000** Shares****000000**Shares****000000**Shares ****000000**Shares****000000**Shares**** 000000**Shares*
**000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares ****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares
****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares **** 000000**Shares**** 000000**Shares****000000**Shares**** 000000**Shares****000000**Shares****000 
000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****
000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares**** 000000**Shares****000000**Shares**** 000000**Shares****000000* Shares****00000 
0**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****
000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares**** 000000**Shares****000000**Shares**** 000000**Shares****000000**Shares****000000* 
*Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****
000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**Shares**** 000000**Shares****000000**Shares****000000**Shares****000000**Shares****000000**S 
FULLY-PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK OF 
Asante Solutions, Inc. (hereinafter
called the “Company”), transferable on the books of the Company in person or by duly authorized attorney, upon surrender of this Certificate properly endorsed. This Certificate and the shares represented hereby, are issued and shall be
held subject to all of the provisions of the Certificate of Incorporation, as amended, and the By-Laws, as amended, of the Company (copies of which are on file with the Company and with the Transfer Agent), to all of which each holder, by acceptance
hereof, assents. This Certificate is not valid unless countersigned and registered by the Transfer Agent and Registrar. 
Witness the facsimile seal of the Company
and the facsimile signatures of its duly authorized officers. 
DATED

DD-MMM-YYYY 
COUNTERSIGNED AND REGISTERED: COMPUTERSHARE TRUST COMPANY, N.A.
TRANSFER AGENT AND REGISTRAR, 
President 
Secretary 
2006 
DELAWARE 
By 
AUTHORIZED SIGNATURE 

 

 
 ASANTE SOLUTIONS, INC. 
THE COMPANY WILL FURNISH
WITHOUT CHARGE TO EACH SHAREHOLDER WHO SO REQUESTS, A SUMMARY OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF STOCK OF THE COMPANY AND THE QUALIFICATIONS, LIMITATIONS OR
RESTRICTIONS OF SUCH PREFERENCES AND RIGHTS, AND THE VARIATIONS IN RIGHTS, PREFERENCES AND LIMITATIONS DETERMINED FOR EACH SERIES, WHICH ARE FIXED BY THE CERTIFICATE OF INCORPORATION OF THE COMPANY, AS AMENDED, AND THE RESOLUTIONS OF THE BOARD OF
DIRECTORS OF THE COMPANY, AND THE AUTHORITY OF THE BOARD OF DIRECTORS TO DETERMINE VARIATIONS FOR FUTURE SERIES. SUCH REQUEST MAY BE MADE TO THE OFFICE OF THE SECRETARY OF THE COMPANY OR TO THE TRANSFER AGENT. THE BOARD OF DIRECTORS MAY REQUIRE THE
OWNER OF A LOST OR DESTROYED STOCK CERTIFICATE, OR HIS LEGAL REPRESENTATIVES, TO GIVE THE COMPANY A BOND TO INDEMNIFY IT AND ITS TRANSFER AGENTS AND REGISTRARS AGAINST ANY CLAIM THAT MAY BE MADE AGAINST THEM ON ACCOUNT OF THE ALLEGED LOSS OR
DESTRUCTION OF ANY SUCH CERTIFICATE. 
The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they
were written out in full according to applicable laws or regulations: 
TEN COM - as tenants in common UNIF GIFT MIN ACT -
.............................................Custodian ................................................ 
(Cust) (Minor) 
TEN ENT - as tenants by the entireties under Uniform Gifts to Minors Act......................................................... 
(State) 
JT TEN - as joint tenants with right of survivorship UNIF TRF MIN ACT -
.............................................Custodian (until age ................................) 
and not as tenants in common (Cust) 
.............................under Uniform Transfers to Minors Act ................... 
(Minor)
(State) 
Additional abbreviations may also be used though not in the above list.

For value received, hereby sell, assign and transfer unto 
PLEASE INSERT
SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE 
(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE) 
Shares of the Common Stock represented by the within Certificate, and do hereby irrevocably constitute and appoint 
Attorney to transfer the said stock on the books of the within-named Company with full power of substitution in the premises. 
Dated: 20 
Signature: 
Signature(s) Guaranteed: Medallion Guarantee Stamp 
THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN
ELIGIBLE GUARANTOR INSTITUTION (Banks, 
Stockbrokers, Savings and Loan Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION
PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15. 
Signature: Notice: The signature to this assignment must correspond with the name as written upon the face of the
certificate, in every particular, without alteration or enlargement, or any change whatever. The IRS requires that we report the cost basis of certain shares acquired after January 1, 2011. If your shares were covered by the legislation and you have
sold or transferred the shares and requested a specific cost basis calculation method, we have processed as requested. If you did not specify a cost basis calculation method, we have defaulted to the first in, first out (FIFO) method. Please visit
our website or consult your tax advisor if you need additional information about cost basis. If you do not keep in contact with us or do not have any activity in your account for the time periods specified by state law, your property could become
subject to state unclaimed property laws and transferred to the appropriate state.EX-4.2.1

 Exhibit 4.2.1 

ASANTE SOLUTIONS, INC. 

AMENDMENT TO THE 

AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

THIS AMENDMENT TO THE AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (the “Amendment”) is made by and among Asante
Solutions, Inc., a Delaware corporation (the “Company”), and the undersigned stockholders of the Company (the “Existing Stockholders”), as of January 21, 2015. 

RECITALS 
 WHEREAS, the
Company and the Existing Stockholders are parties to that certain Amended and Restated Investors’ Rights Agreement, dated September 3, 2014 (the “Rights Agreement”); 

WHEREAS, the Company shall enter into a Common Stock Purchase Agreement with certain of the Existing Stockholders pursuant to which such
Existing Stockholders will purchase shares of the Company’s common stock (the “Shares”) concurrently with the closing of the IPO (as defined therein); 

WHEREAS, the Company and the Existing Stockholders now desire to amend the terms of the Rights Agreement as set forth herein to include the
Shares as Registrable Securities under the Rights Agreement; and 
 WHEREAS, the Existing Stockholders constitute the Requisite Investors
(as defined in the Rights Agreement), and the consent of such holders will bind all parties to the Rights Agreement pursuant to Sections 2.13 and 5.1 thereof. 

NOW, THEREFORE, THE PARTIES HEREBY AGREE AS FOLLOWS: 

1. Definition Amendment. Pursuant to Section 5.1 of the Rights Agreement, Section 1.1(r) of the Rights Agreement shall be
replaced in its entirety by the following: 
 “(r) “Registrable Securities” shall mean (i) shares of Common Stock
issued or issuable pursuant to the conversion of the Preferred Stock held by the Investors or their permitted assigns to whom registration rights are transferred in accordance with this Agreement, (ii) any Common Stock issued as distribution
with respect to or in exchange for or in replacement of the shares referenced in (i) above, (iii) Common Stock issued upon exercise of those certain Common Stock warrants dated July 17, 2007 issued to Thomas McNerney &
Partners II, L.P. and De Novo Ventures III, L.P. and their respective affiliates, (iv) the Common Stock that shall be issued pursuant to that certain Common Stock Purchase Agreement by and between the Company and the investors listed on
Schedule A thereto dated on or about January 15, 2015, and (v) Common Stock issued or issuable upon exercise and conversion of any Preferred Stock warrant of the Company held by the Investors or their permitted assigns to whom
registration rights are transferred in accordance with this Agreement; provided, however, that Registrable 

 
Securities shall not include any shares of Common Stock described in clause (i), (ii), (iii), (iv) and (v) above which have previously been registered or which have been sold to the
public either pursuant to a registration statement or Rule 144, or which have been sold in a private transaction in which the transferor’s rights under this Agreement are not validly assigned in accordance with this Agreement.” 

2. Lock-up Extension. Pursuant to Section 5.1 of the Rights Agreement, Section 2.10 of the Rights Agreement shall be
replaced in its entirety by the following 
 2.10 Market Stand-Off Agreement 

Each Holder and Common Holder shall not sell or otherwise transfer, make any short sale of, grant any option for the purchase of, or enter
into any hedging or similar transaction with the same economic effect as a sale of, any Common Stock (or other securities) of the Company held by such Holder or Common Holder (other than those included in the registration) during the six
(6) month period following the effective date of the Registration Statement on Form S-1 for the Company’s Initial Public Offering filed under the Securities Act (such date the “Effective Date”). Each Holder and Common
Holder (other than JLP Consulting LLC and Morten Mernoe) shall not sell or otherwise transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale of,
any Common Stock (or other securities) of the Company held by such Holder or Common Holder (other than those included in the registration) during the eighteen (18) month period following the Effective Date, unless a shorter period is approved
by 66-2/3% of the then outstanding shares of Common Stock held by the Holders and Common Holders (voting together as a single class on an as-converted basis) (such shorter period, the “Reduced Lock-Up Period”); provided that
such Reduced Lock-Up Period shall be no less than six (6) months from the Effective Date. 
 The obligations described in this
Section 2.10 shall not apply to a registration relating solely to employee benefit plans on Form S-l or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a transaction on Form S-4 or
similar forms that may be promulgated in the future. The Company may impose stop-transfer instructions and may stamp each such certificate with the second legend set forth in Section 2.8(c) hereof with respect to the shares of Common
Stock (or other securities) subject to the foregoing restriction until the end of such eighteen (18) month period or the Reduced Lock-Up Period, as applicable. Each Holder and Common Holder agrees to execute a market standoff agreement with
said underwriters in customary form for a period of at least six (6) months. 
 3. Continued Validity of the Rights Agreement.
Except as amended hereby, the Rights Agreement shall continue in full force and effect as originally constituted and is ratified and affirmed by the parties hereto. 

4. Successors and Assigns. Except as otherwise provided herein, the terms and conditions of this Amendment shall inure to the benefit
of and be binding upon the respective successors and assigns of the parties. 
 5. Governing Law. This Amendment shall be governed
in all respects by the internal laws of the State of Delaware, without regard to principles of conflicts of law. 

  
 2 

 6. Counterparts. This Amendment may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 7. Jurisdiction;
Venue. With respect to any disputes arising out of or related to this Amendment, the parties (a) consent to the exclusive jurisdiction of, and venue in, the federal and state courts located within the geographical boundaries of the United
States District Court for the District of Delaware for the purpose of any suit, action or other proceeding arising out of or based upon this Amendment, (b) agree not to commence any suit, action or other proceeding arising out of or based upon
this Amendment except in the federal and state courts located within the geographical boundaries of the United States District Court for the District of Delaware, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or
otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is
brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Amendment or the subject matter hereof may not be enforced in or by such court. Each of the parties to this Amendment consents to personal
jurisdiction for any equitable action sought in the U.S. District Court for the District of Delaware or Chancery Court of Delaware to the extent having subject matter jurisdiction. 

[Remainder of page intentionally left blank.] 

  
 3 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

							
	COMPANY:		
		
			ASANTE SOLUTIONS, INC.
			a Delaware corporation
			
			By:		 /s/ David Thrower

				
					Name:		 David Thrower

				
					Title:		 Chief Executive Officer

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

			
	 EXISTING STOCKHOLDERS:

	
	Thomas, McNerney & Partners II, L.P.
		
	By:		Thomas, McNerney & Partners II, LLC
	Its:		General Partner
		
	By:		 /s/ James Thomas

	Name:		James Thomas
	Title:		Manager
	
	TMP Nominee II, LLC
		
	By:		 /s/ James Thomas

	Name:		James Thomas
	Title:		Manager
	
	TMP Associates II, L.P.
		
	By:		Thomas, McNerney & Partners II, LLC
	Its:		General Partner
		
	By:		 /s/ James Thomas

	Name:		James Thomas
	Title:		Manager
	
	Address:
	60 South 6th Street
	Suite 3620
	Minneapolis, MN 55402
	
	Fax: [redacted]
	E-mail: [redacted]

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

					
	EXISTING STOCKHOLDERS:
		
			De Novo Ventures III, L.P.
			By:		De Novo Management III, LLC
			Its:		General Partner
			
			By:		 /s/ Joe Mandato

			Joe Mandato, Managing Director
		
			Address:
			 14612 Big Basin Way

			 Suite B

			 Saratoga, CA 95070

			 E-mail: [redacted]

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

			
	EXISTING STOCKHOLDERS:
	
	NOVO A/S
		
	By:	 	 /s/ Thomas Dyrberg MD

		
	Name:	 	 Thomas Dyrberg

		
	Title:	 	 Senior Partner

	
	Address: Tuborg Havnevej 19
	    DK 2900 Hellerup

	    Denmark

	    Attn: Heather Ludvigsen

	    Fax:

	    E-mail: [redacted]

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

					
	EXISTING STOCKHOLDERS:
	
	Sunstone Life Science Ventures Fund I K/S
			
	By:	 	 /s/ Peter Benson
	 	 /s/ Merete Moller

			
	Name:	 	 Peter Benson
	 	 Merete Moller

			
	Title:	 	 Managing Partner
	 	 Partner

		
	Address: Lautrupsgade 7, 5	 	
	    2100 Copenhagen
	 	
	    Denmark
	 	
	    Attn: Mr. Peter Benson
	 	
	    Fax: [redacted]
	 	
	    E-mail: [redacted]
	 	
	    Copy: [redacted]
	 	

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

					
		 	EXISTING STOCKHOLDERS:
		
		 	SeeD Capital Denmark K/S
			
		 	By:	 	 /s/ Ulla Brockenhuus-Schack

			
		 	Name:	 	 Ulla Brockenhuus-Schack

			
		 	Title:	 	 Managing Partner

			
		 	By:	 	 /s/ Lars Anderson

			
		 	Name:	 	 Lars Anderson

			
		 	Title:	 	 General Partner

	
	Address: Diplomvej 381, DK-2800 Kgs. Lyngby
	    Attn: Ulla Brockenhuus-Schack

	    Fax: [redacted]

	    E-mail: [redacted]

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date first above written.

  

			
	EXISTING STOCKHOLDERS:
	
	Lundbeckfond Invest A/S
		
	By:	 	 /s/ Lene Skole

	Name:	 	Lene Skole
	Title:	 	CEO
		
	By:	 	 /s/ Mette Kirstine Agger

	Name:	 	Mette Kirstine Agger
	Title:	 	Managing Partner

 
			
		
	Address:	  	Scherfigsvej 7,
		  	DK-2100 København Ø
		  	Denmark
	Fax:	  	[redacted]
	E-mail:	  	[redacted]

  

SIGNATURE PAGE TO THE ASANTE SOLUTIONS,
INC. AMENDMENT TO 
 AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT

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