Document:

EX-10(XXV)

 Exhibit 10(xxv) 

[ENCANA LETTERHEAD] 
 October 21, 2014 

Nucor Energy Holdings Inc. 
 1915 Rexford Road 

Charlotte, North Carolina 28211 
 Attn: Chief Financial Officer

 Attn: Mr. Brad True 
  

	 	RE:	 First Amendment to the BJU Carry and Earning Agreement (“Agreement”) effective 

	 	    	 November 1, 2012 by and among Encana Oil & Gas (USA) Inc. (“Encana”), Nucor 

	 	    	 Energy Holdings Inc. and Nucor Corporation (collectively, “Nucor”) 

Dear Brad: 
 Pursuant to our
recent discussions, Encana and Nucor (collectively, the “Parties”) have agreed to amend the Agreement to revise the drilling schedule for 2015 and provide for an optional Head’s Up Well drilling program in calendar year 2016. 

In light of the foregoing, and in consideration of the mutual covenants and agreements herein, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows: 
 AGREEMENT 

 

	 	1.	 Defined Terms.    Each capitalized term used in this first amendment (“First Amendment”), to the extent not
expressly defined herein, shall have the same meaning ascribed to such term in the Agreement. 

  

	 	2.	 Amendment to Section 2.2A of the Agreement.    The second sentence in Section 2.2A is hereby deleted and
replaced with the following two sentences: 

 During calendar year 2015, the Parties
agree that drilling operations will be limited to [***] total Carry Wells on the [***] of the Big Jimmy Unit, which comprises a portion of the Property. For the calendar year 2016 and thereafter, Encana shall spud a minimum of [***] and a maximum of
[***] Carry Wells in each calendar year until such time as the Carry Well Threshold has been met. 
  

	 	3.	 Addition of Section 2.4G to the Agreement.    The following provisions are hereby incorporated into the Agreement
as Section 2.4G and subsections: 

  

	 	    	 2.4G. Optional HUW Program. 

(i)     On or before September 1, 2015, Encana will offer to Nucor in writing
(“Optional HUW Program Notice”) the opportunity to participate in an optional Head’s Up Well program (“Optional HUW Program”) 

  
 [***] This confidential information
has been omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment. 

 
whereby [***] of the drilling rigs that would otherwise be dedicated to drilling Carry Wells in calendar year 2016 would instead be dedicated to drilling only Head’s Up Wells in calendar
year 2016. The location of the Head’s Up Wells to be drilled pursuant to the Optional HUW Program would be determined in a manner consistent with Section 2.1B. Nucor shall have fifteen (15) days from receipt of the Optional HUW
Program Notice to make a one-time election in writing (“Nucor Election”) to participate in the Optional HUW Program. If Nucor elects to participate in the Optional HUW Program, Encana shall have fifteen (15) days from receipt of the
Nucor Election to advise Nucor in writing whether Encana elects to participate in the Optional HUW Program (“Encana Election”). If Encana elects not to participate in the Optional HUW Program, Nucor shall have fifteen (15) days after
receipt of the Encana Election to reaffirm the Nucor Election in writing to Encana. Each Party shall be deemed to have elected not to participate in the Optional HUW Program if it fails to timely provide its Election or affirmation of its Election,
as applicable, as required by this Section 2.4G(i). If a Party elects to participate in the Optional HUW Program, it has elected to participate in the entirety of the Program and may not decline to participate in any Head’s Up Well drilled
pursuant to the Optional HUW Program. If both Parties decline to participate in the Optional HUW Program, Encana may, in its sole discretion, release or redeploy the designated Head’s Up Well drilling rig to non-Nucor drilling activity. The
Parties expressly agree that Encana may simultaneously drill Head’s Up Wells pursuant to the Optional HUW Program and Carry Wells. The Parties further agree that any Head’s Up Wells drilled pursuant to the Optional HUW Program shall
(1) count toward satisfaction of the minimum number of wells required to be drilled pursuant to Section 2.2A and (2) be excluded from the number of Carry Wells used to determine the HUW Restriction for calendar year 2017. 

(ii)     So long as both Parties elect to participate, each Head’s Up Well drilled
pursuant to the Optional HUW Program shall be counted as one well toward the Well Limit. If only Nucor participates, each Head’s Up Well drilled pursuant to the Optional HUW Program shall be counted as two wells toward the Well Limit. 

(iii)     If both Parties elect to participate in the Optional HUW Program, each Party
shall bear fifty percent (50%) of the costs of the Program. If Encana elects not to participate in an Optional HUW Program and Nucor elects to proceed with such Optional HUW Program, the Parties shall proceed in accordance with
Section 4.2. 
  

	 	4.	 Amendment to Section 2.1(H)(i) of the Agreement. Section 2.1(H)(i) of the Agreement is hereby amended by adding the
following sentence immediately after the first sentence of such Section: 

Notwithstanding anything to the contrary set forth herein, in the event any changes in Applicable Law or
interpretations thereof by any Governmental Authorities have the effect of making the form of wellbore assignment attached hereto as Exhibit C insufficient to grant to Nucor rights to Nucor Wells (whether existing or subsequently
completed), oil 

  
 [***] This confidential information
has been omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment. 

 
and gas production therefrom and equipment related thereto, in each case as contemplated in this Agreement or in the New Operating Agreement, the Parties agree to amend any existing Wellbore
Assignments as well as the form of wellbore assignment to the extent necessary to preserve and maintain Nucor’s rights in the foregoing as contemplated in this Agreement or in the New Operating Agreement. 

 

	 	5.	 Amendment to Exhibit C of the Agreement.    The Exhibit C attached to the Agreement is hereby deleted in its
entirety and replaced with the Form of Wellbore Assignment and Conveyance attached hereto as Exhibit C. 

  

	 	6.	 Execution.    This First Amendment may be executed in one or more counterparts, each of which shall be deemed an
original and when taken together shall constitute one and the same document. Facsimile and/or electronically transmitted copies of signatures shall be binding. 

 

	 	7.	 Effect of Amendment.    Except as specifically amended by this First Amendment, the terms and provisions stated in the
Agreement, including all exhibits thereto, remain in full force and effect as amended hereby and constitute the entire agreement between the Parties relating to this matter and supersede all prior and contemporaneous agreements and understandings of
the Parties. In the event of any inconsistency, the terms and provisions of this First Amendment shall control over and modify the inconsistent terms and provisions of the Agreement. 

 

	 	8.	 Binding Effect.    This First Amendment shall be binding upon and inure to the benefit of the Parties’ permitted
heirs, successors and assigns. 

 Sincerely, 

Encana Oil & Gas (USA) Inc. 
 by its authorized agent,

 Encana Services Company Ltd. 
 /s/ Jeffrey S. Balmer 

Jeffrey S. Balmer 
 Vice President and General Manager 

Western Operations 
  

									
	 AGREED AND ACCEPTED, this 21st
 day
of October, 2014
				 AGREED AND ACCEPTED, this 21st
 day
of October, 2014

			
	 Nucor Energy Holdings Inc.
				 Nucor Corporation

					
	By:		/s/ Bradford G. True				By:		/s/ Bradford G. True
	 Bradford G. True
 Vice
President
				 Bradford G. True
 General
Manager

 EXHIBIT C 

Attached to and made a part of the BJU Carry & Earning Agreement executed October 31, 2012 but effective 

November 1, 2012 by and between Encana Oil & Gas (USA) Inc. and Nucor Energy Holdings Inc. 

Form of Wellbore Assignment and Conveyance 
  

					
	THE STATE OF COLORADO		§		
			§		KNOW ALL MEN BY THESE PRESENTS:
			§		

 THAT Encana Oil & Gas (USA) Inc., whose address is 370 17th Street, Suite 1700, Denver, CO 80202 (hereinafter referred to as “Assignor”) for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged and
confessed, does hereby GRANT, BARGAIN, SELL, TRANSFER, ASSIGN, AND CONVEY unto Nucor Energy Holdings Inc., whose address is 1915 Rexford Road, Charlotte, NC 28211 (hereinafter referred to as “Assignee”) an undivided fifty percent
(50.00%) of Assignor’s right, title, interest, and estate in and to the following, subject to the limitations below (collectively, the “Assigned Interests”): 

 

	 	a.	 The wells and their associated wellbores described on Exhibit A or, subject to the terms and conditions of that certain unrecorded New Operating
Agreement dated effective November 1, 2012 by and between Assignor and Assignee, (i) any plugging back, reworking or recompletion thereof through or from such wells and their associated wellbores, and (ii) any perforation or
stimulation of any of the foregoing (each, individually, a “Well” and collectively, the “Wells”): 

  

	 	b.	 The rights in and to the oil and gas leases described on the attached Exhibit B (“Leases”), and all pooled, communitized or unitized
acreage which includes any part of the Leases insofar and only insofar as said Leases and pooled, communitized or unitized acreage are necessary to operate, maintain, produce and plug and abandon the Wells. 

 

	 	c.	 All personal property and fixtures associated with the Wells, including without limitation the following: all tubing, casing and other equipment in
the wellbore, wellhead equipment and surface production facilities. 

  

	 	d.	 All oil, gas, gas condensate, casinghead gas and/or all other liquid or gaseous hydrocarbons and other substances produced therewith from the
Wells. 

 Assignor and Assignee further agree as follows: 

 

	 	1.	 This Assignment is made and accepted subject to, and Assignee hereby assumes, any and all overriding royalties, payments out of production, and
other burdens or encumbrances of record as of November 1, 2012 to the extent the same cover and affect the Assigned Interests. 

	 	2.	 Assignee accepts the Assigned Interests subject to all of the express and implied covenants and obligations of the Leases, insofar as they relate
to the Assigned Interests. 

  

	 	3.	 This Assignment is made by Assignor and accepted by Assignee without any warranty whatsoever and without warranty of title, either express or
implied, and without recourse, except that Assignor warrants title as against all parties claiming an interest in the Assigned Interests by, through or under Assignor. This Assignment is made with full substitution and subrogation of Assignee in and
to all covenants and warranties heretofore made or given by others. 

  

	 	4.	 This Assignment is made in accordance with, and is subject to all the terms, provisions, and conditions of, that certain BJU Carry and Earning
Agreement effective November 1, 2012, between Assignor and Assignee (“Carry and Earning Agreement”) which is incorporated by this reference the same as though fully set out herein. However, this assignment is neither intended as,
nor shall it be deemed to accomplish, a merger of the terms and provisions directly set out herein and the terms and provisions of said Carry and Earning Agreement. Should there be any conflict between this Assignment and the Carry and Earning
Agreement, the terms and conditions set out in the Carry and Earning Agreement shall prevail. 

  

	 	5.	 This Assignment is subject to that certain unrecorded New Operating Agreement effective November 1, 2012. 

 

	 	6.	 The Assigned Interests do not include, and Assignor does not intend to assign and Assignee does not intend to receive, any interest in the
following to the extent that such items do not directly relate to the operation of, and production oil, gas, gas condensate, casinghead gas and/or all other liquid and gaseous hydrocarbons and other substances produced therewith from, a Well: all
lands, minerals, oil and gas leases and lands pooled therewith, units, working interests, executory interests, reversionary interests, net profits interests, net revenue interests, term interests, royalty and overriding royalty interests, fee
interests, surface interests, and any other interests of a similar nature, all contracts, agreements, licenses, and servitudes, all easements, leases, surface use, and right-of-way agreements, all other property and equipment not directly used in
connection with the operation and production of the Wells and any and all rights not expressly herein conveyed as part of the Assigned Interests. 

  

	 	7.	 The Assigned Interests do not include, and Assignor does not intend to assign and Assignee does not intend to receive, any overriding royalty
interest owned by Assignor in existence as of November 1, 2012, except as may be otherwise provided in the Carry and Earning Agreement. 

  

	 	8.	 The Assigned Interest is hereby limited from the surface to the deepest depth drilled in each Well. 

TO HAVE AND TO HOLD the Assigned Interests unto Assignee and its successors and assigns, subject to all the express and implied covenants and
obligations of the Leases and this Assignment. 

 EXECUTED this ___ day of ____2014, but effective as of the date of first production for each Well as set
forth on Exhibit A. 
  

			
	 ENCANA OIL & GAS (USA) INC.
 by its authorized agent,
 Encana Services Company Ltd.

		
	By:	 	 
		 	Constance D. Heath
		 	Director, Land Negotiation, Western Operations

  

			
	NUCOR ENERGY HOLDINGS INC.
		
	By:	 	 
		 	Bradford G. True
		 	Vice President

 ACKNOWLEDGEMENTS 
  

					
	 STATE OF COLORADO
		§		
			§		
	 CITY AND COUNTY OF DENVER
		§		

 BEFORE ME, the undersigned authority, on this day personally appeared Constance D. Heath,
Director, Land Negotiation, Western Operations for Encana Services Company Ltd, authorized agent for ENCANA OIL & GAS (USA) INC. known to me to be the person whose name is subscribed to the foregoing instrument, and acknowledged to me that
she executed the same for the purposes and consideration therein expressed and in the capacity therein stated. 
 GIVEN
UNDER MY HAND AND OFFICIAL SEAL OF OFFICE on this ____ day of __________, 2014. 
  

					
	MY COMMISSION EXPIRES:				
	 				 
					Notary Public in and for the State of Colorado

  

			
	 STATE OF    _________________________________
		 §

			 §

	 COUNTY OF    _______________________________
		 §

 BEFORE ME, the undersigned authority, on this day personally appeared, Bradford G. True, Vice
President for NUCOR ENERGY HOLDINGS INC. known to me to be the person whose name is subscribed to the foregoing instrument, and acknowledged to me that he executed the same for the purposes and consideration therein expressed and in the capacity
therein stated. 
 GIVEN UNDER MY HAND AND OFFICIAL SEAL OF OFFICE on this ____ day of __________, 2014. 

 

					
	MY COMMISSION EXPIRES:				
	 				 
					Notary Public

 Recording Requested and when RecordedEXHIBIT 10.1

 

THIS
NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”). THIS NOTE HAS BEEN
ACQUIRED FOR INVESTMENT ONLY AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF REGISTRATION OF THE RESALE THEREOF
UNDER THE SECURITIES ACT OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY IN FORM, SCOPE AND SUBSTANCE TO THE COMPANY THAT SUCH
REGISTRATION IS NOT REQUIRED.

 

PROMISSORY
NOTE

 

	$1,200,000	 	Dated
    as of February 23, 2015
	 	 	Los Angeles,
    California

 

Targeted
Medical Pharma, Inc. (the “Maker”) promises to pay to the order of Shlomo Rechnitz or his registered assigns
or successors in interest (the “Holder”), or order, the principal
sum of One Million Two Hundred Thousand Dollars ($1,200,000) in lawful money of the United States of America, on the terms and
conditions described below. All payments on this Note shall be made by check or wire transfer of immediately available funds or
as otherwise determined by the Maker to such account as the Holder may from time to time designate by written notice in accordance
with the provisions of this Note.

 

1. Principal.
The unpaid principal and accrued interest shall be payable in monthly installments of $52,109.91, beginning on March 22, 2015,
and continuing until February 22, 2017 (the “Due Date”).

 

2. Interest.
Interest shall accrue at a rate of 4% per annum on the unpaid principal balance of this Note.

 

3. Application
of Payments. All payments shall be applied first to payment in full of any costs incurred in the collection of any sum due
under this Note, including (without limitation) reasonable attorney’s fees, then to the payment in full of any late charges,
then to the payment of interest on the unpaid principal and finally to the reduction of the unpaid principal balance of this Note.

 

4. Events
of Default. The following shall constitute Events of Default:

 

(a) Failure
to Make Required Payments. Failure by Maker to pay the principal and interest of this Note within five (5) business days following
the date when due.

 

(b) Voluntary
Bankruptcy, Etc. The commencement by Maker of a voluntary case under the Federal Bankruptcy Code, as now constituted or hereafter
amended, or any other applicable federal or state bankruptcy, insolvency, reorganization, rehabilitation or other similar law,
or the consent by it to the appointment of or taking possession by a receiver, liquidator, assignee, trustee, custodian, sequestrator
(or other similar official) of Maker or for any substantial part of its property, or the making by it of any assignment for the
benefit of creditors, or the failure of Maker generally to pay its debts as such debts become due, or the taking of corporate
action by Maker in furtherance of any of the foregoing.

 

    	 

    	 

    

 

(c) Involuntary
Bankruptcy, Etc. The entry of a decree or order for relief by a court having jurisdiction in the premises in respect of Maker
in an involuntary case under the Federal Bankruptcy Code, as now or hereafter constituted, or any other applicable federal or
state bankruptcy, insolvency or other similar law, or appointing a receiver, liquidator, assignee, custodian, trustee, sequestrator
(or similar official) of Maker or for any substantial part of its property, or ordering the winding-up or liquidation of its affairs,
and the continuance of any such decree or order unstayed and in effect for a period of 60 consecutive days.

 

(d) David
S. Silver, M.D. shall cease to serve as an employee of the Company; provided, however that no Event of Default shall
occur if (i) Dr. Silver is earlier terminated by the Company for Cause or as a result of death or (ii) the Company appoints a
qualified successor that is reasonably acceptable to the Holder within 90 days of the termination date

 

(e) William
E. Shell, M.D. shall return as an employee of the Company.

 

5. Remedies.

 

(a) Upon
the occurrence of an Event of Default specified in Section 4(a), Holder may, by written notice to Maker, declare this Note to
be due and payable, whereupon the principal amount of this Note, and all other amounts payable thereunder, shall become immediately
due and payable without presentment, demand, protest or other notice of any kind, all of which are hereby expressly waived, anything
contained herein or in the documents evidencing the same to the contrary notwithstanding.

 

(b) Upon
the occurrence of an Event of Default specified in Sections 4(b) and 4(c), the unpaid principal balance of, and all other sums
payable with regard to, this Note shall automatically and immediately become due and payable, in all cases without any action
on the part of Holder.

 

6. Waivers.
Maker and all endorsers and guarantors of, and sureties for, this Note waive presentment for payment, demand, notice of dishonor,
protest, and notice of protest with regard to the Note, all errors, defects and imperfections in any proceedings instituted by
Holder under the terms of this Note, and all benefits that might accrue to Maker by virtue of any present or future laws exempting
any property, real or personal, or any part of the proceeds arising from any sale of any such property, from attachment, levy
or sale under execution, or providing for any stay of execution, exemption from civil process, or extension of time for payment;
and Maker agrees that any real estate that may be levied upon pursuant to a judgment obtained by virtue hereof, on any writ of
execution issued hereon, may be sold upon any such writ in whole or in part in any order desired by Holder.

 

7. Unconditional
Liability. Maker hereby waives all notices in connection with the delivery, acceptance, performance, default, or enforcement
of the payment of this Note, and agrees that its liability shall be unconditional, without regard to the liability of any other
party, and shall not be affected in any manner by any indulgence, extension of time, renewal, waiver or modification granted or
consented to by Holder, and consents to any and all extensions of time, renewals, waivers, or modifications that may be granted
by Holder with respect to the payment or other provisions of this Note, and agree that additional makers, endorsers, guarantors,
or sureties may become parties hereto without notice to them or affecting their liability hereunder.

 

    	2

    	 

    

 

8. Notices.
Any notice called for hereunder shall be deemed properly given if (i) sent by certified mail, return receipt requested, (ii)
personally delivered, (iii) dispatched by any form of private or governmental express mail or delivery service providing receipted
delivery or (iv) sent by telefacsimile or (v) to the following addresses or to such other address as either party may designate
by notice in accordance with this Section:

 

If
to Maker:

Targeted
Medical Pharma, Inc.

2980 Beverly
Glen Circle, Suite 301

Los Angeles,
California 90077

 

If
to Holder:

Shlomo
Rechnitz

C/O
Devora Pinson

5900
Wilshire Blvd., Suite 2600

Los
Angeles, California 90036

 

Notice
shall be deemed given on the earlier of (i) actual receipt by the receiving party, (ii) the date shown on a telefacsimile transmission
confirmation, (iii) the date reflected on a signed delivery receipt, or (iv) two (2) Business Days following tender of delivery
or dispatch by express mail or delivery service.

 

9.
 Construction. THIS NOTE SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH THE DOMESTIC, INTERNAL LAW, BUT NOT
THE LAW OF CONFLICT OF LAWS, OF THE STATE OF CALIFORNIA.

 

10.
 Severability. Any provision contained in this Note which is prohibited or unenforceable in any jurisdiction shall,
as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining
provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable
such provision in any other jurisdiction.

 

IN
WITNESS WHEREOF, Maker, intending to be legally bound hereby, has caused this Note to be duly executed by its Chief Executive
Officer the day and year first above written.

 

	 	TARGETED MEDICAL PHARMA, INC.
	 	 	 
	 	By:	/s/
    Kim Giffoni
	 	Name:	Kim Giffoni
	 	Title:	Chief Executive Officer

 

    	3

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