Document:

Exhibit 10.93d
    

    
      First Amendment to Executive Employment
      Agreement with Larry Tiffany
    

    

    

    
      This amendment is made as of the 1st day of January 2008 (the “Amendment
      Effective Date”) by and between Ore Pharmaceuticals Inc. (formerly Gene
      Logic Inc.,) a Delaware corporation (the “Company”), and Larry Tiffany
      (“Executive”).

    

    
      The parties to this amendment have previously entered into an Employment
      Agreement with an Effective Date of February 1, 2007 referred to herein
      as the “Agreement”. The parties now wish to amend certain terms of the
      Agreement. Terms not otherwise defined herein shall have the meanings as
      defined in the Agreement.

    

    
      The parties to this amendment hereby agree to modify, replace and/or
      supercede certain portions of the Agreement as follows:

    

    	
        Position. Section 1.1 (a) is hereby amended by inserting the
        following text immediately after the first sentence thereof: “From and
        after the Amendment Effective Date, the Company shall continue the
        employment of the Executive but in a new dual role as Senior Vice
        President and Interim Head, Commercial Operations of the Company and
        President and Chief Executive of one of its subsidiaries, DioGenix
        Inc. (“Diogenix”), reporting to the Chief Executive Officer (“CEO”) of
        the Company.”

      
	
        Allocation of Time. Section 1.1 (b) is hereby amended by
        inserting the following text immediately after the first sentence
        thereof: “ From and after the Amendment Effective Date, unless
        otherwise directed by the CEO, the Executive shall devote
        approximately two-thirds (2/3) of his working time and creative
        energies to the performance of his duties as Interim Head, Commercial
        Operations and approximately one-third (1/3) of his working time and
        creative energies to the performance of duties as President & Chief
        Executive of DioGenix.”

      
	
        Term of Employment. Section 2 of the Agreement is hereby
        amended by deleting the first sentence thereof and inserting in lieu
        thereof the following: “The Executive’s term of employment by the
        Company (the “Term”) shall commence on the Effective Date and continue
        thereafter on an at-will basis until the earlier of December 31, 2008
        or until terminated by either party pursuant to Section 4 hereof. The
        Term may only be extended by an amendment to the Agreement executed by
        both parties.”

      
	
        Allocation of Base Salary. Section 3.1 shall be amended by
        adding the following sentence at the end of such section: “One third
        of the Base Salary shall be allocated to DioGenix and shall be
        reimbursed to Company from funds or budgets available to DioGenix. If
        the CEO changes the proportion of Executive’s time allocated to
        DioGenix, the amount of reimbursement shall be appropriately adjusted.
        “

      
	
        Incentive Compensation. Section 3.2.2 shall be replaced in its
        entirety with: “3.2.2. From and after the Amendment Effective Date, no
        further compensation will be payable under Section 3.2.1. Instead,
        Executive will be eligible to participate in the Company’s 2008
        Incentive Compensation Plan established by the Compensation Committee
        of the Board (the “Compensation Committee”) and generally applicable
        to employees of the Company other than Business Development. The
        target incentive compensation for Executive for the Company’s fiscal
        year 2008, which shall be based on achieving 100% of the targets and
        levels of performance established by the Compensation Committee, will
        be $75,000, less applicable withholding and other authorized
        deductions. To receive incentive compensation under this section 3.2.2
        for 2008, the Executive must be employed by the Company on a full-time
        basis as of the last business day of 2008.”

      
	
        Retention Payments. Section 3.2.3 shall be replaced in its
        entirety with: “3.2.3 From and after the Amendment Effective Date, in
        addition to the incentive compensation described in Section 3.2.2,
        Executive shall be entitled to receive a retention payment (herein a
        “Retention Payment”) of $37,500 per each 2008 calendar quarter, less
        applicable withholding and other authorized deductions, payable within
        thirty days after the end of each calendar quarter, provided that as
        to each quarter for which payment is being made, Executive’s
        employment by the Company on a full-time basis continued through the
        last business day of such calendar quarter. Notwithstanding the
        preceding, if, during 2008, Executive’s employment is terminated by
        Company without “Cause” (as defined in Attachment A) or the Company
        experiences a change of control, then the Retention Payments for 2008
        described herein not previously paid shall be accelerated and
        Executive shall be entitled to receive the remainder of the 2008
        Retention Payments that have not already been paid within 30 days
        after the termination or occurrence of the change of control. In no
        event will acceleration of such Retention Payments be made based on a
        voluntary resignation by Executive or any other type of termination of
        his employment other than as specifically described in the preceding
        sentence. As used herein, the term “change of control” shall have the
        same meaning as in the Company’s Executive Severance Plan as amended
        and restated as of February 23, 2001.

      
	
        Elimination of Benefit. Effective as of the Amendment Effective
        Date, Section 3.8 relating to Tax/Financial Planning will be stricken
        in its entirety.

      
	
        Payments upon Termination. Section 4.7 shall be amended by
        deleting the same and inserting in lieu thereof the following: “ 4.7
        Upon termination of the Executive’s employment by the Company, whether
        by the Executive ‘s resignation, by the Company for Cause or without
        Cause or as a result of death or Disability, or in any other
        circumstance, the Company shall have no obligation to pay the
        Executive any compensation other than compensation earned or accrued
        through the last day of employment and for Executive’s accrued and
        unused paid time off as of the date of termination. In particular, the
        Executive will not be entitled to any severance payment or benefits.”

      
	
        Restrictive Covenants/Definitions. Section 5.2(a) of the
        Agreement is hereby amended by deleting the same and substituting in
        lieu thereof the following: “(a) Business” for purposes of this
        Article 5 shall mean (i) repositioning drug compounds and then
        developing and outlicensing such compounds repositioned by the Company
        and the provision of drug repositioning services to pharmaceutical
        companies and other third parties; (ii) the development of diagnostic
        products and services using the tools and processes developed by the
        Company, including the genomics databases developed by the Company’s
        former Genomics Division, and (iii) the provision or licensing of
        genomic information and databases and bioinformatics products and
        services to the pharmaceutical and biotechnology industry including
        biosample collection, handling and processing, genomic data
        production, and data management and software systems development, and
        (iv) any other products and services offered from time to time after
        the Effective Date and prior to the Termination Date by the GLGC
        Group, as described in its annual and quarterly reports filed with the
        Securities and Exchange Commission.

      
	
        Notice: Section 9.1(a) is hereby amended by deleting the same
        and substituting in lieu thereof the following: (a) if to Company, to:
        Ore Pharmaceuticals Inc., 610 Professional Drive, Suite 101,
        Gaithersburg, MD, 20879, Attn: Chief Executive Officer, with a copy to
        : Ariel Vannier, Esq., Venable LLP, 575 7th Street, NW,
        Washington DC 20004.”

      
	
        Change of Name. Since the Agreement was executed, the Company
        has changed its name from Gene Logic Inc. to Ore Pharmaceuticals Inc.
        References herein or in the Agreement, the Proprietary Information and
        Inventions Agreement or any other related agreement to either of Gene
        Logic Inc, or Ore Pharmaceuticals Inc. or any acronym or abbreviation
        therefore shall be deemed to include both names and to the entity
        herein defined as the Company. Any reference to the GLGC Group in any
        of the above agreements shall mean the Company and its subsidiaries.

      

    
      
        

        

      

      
        

        

        
          

        

      

      
        

        

      

    

    
      To evidence their agreement to the terms of this Amendment, Company and
      Executive have each caused this Amendment to be executed on behalf of
      each party by its duly authorized representative.

    

    

    

    	
          
            Ore Pharmaceuticals Inc.
          

        	
          
            Executive
          

        
	

        	
           
        
	
          
            By:
          

        	
          
               /s/ Charles L. Dimmler, III
          

        	
          
            By:
          

        	
          
               /s/ Larry Tiffany
          

        
	

        	
          
            Charles L. Dimmler, III
          

        	

        	
          
            Larry Tiffany
          

        
	

        	
          
            CEO, Ore Pharmaceuticals Inc.EXHBIT 10.1

                           FIFTH AMENDMENT TO LEASE

      THIS FIFTH AMENDMENT TO LEASE ("Fifth Amendment") is made this 19th day of
March, 2008 (the "Effective Date"),  between DAVID D. BOHANNON  ORGANIZATION,  a
California corporation, herein referred to as "Landlord", and GERON CORPORATION,
a Delaware corporation, herein referred to as "Tenant".

                                   WITNESSETH:

      WHEREAS,  Landlord and Tenant entered into a Lease entitled "Business Park
Lease" dated January 20, 1993, for certain demised  premises  located at 194-200
Constitution Drive, Menlo Park,  California,  as more particularly  described in
said Lease, and

      WHEREAS,  the Lease has been  amended by a First  Amendment to Lease dated
July 26,  1993,  a Second  Amendment  to Lease dated  February 22, 1994, a Third
Amendment to Lease dated March 25, 1996,  and a Fourth  Amendment to Lease dated
March 23, 2004 (the "Fourth Amendment") (the Lease, as previously amended by the
foregoing amendments, is herein referred to as the "Lease"), and

      WHEREAS,  the Lease is scheduled to expire on July 31, 2008,  and Landlord
and Tenant desire to make certain amendments to the Lease and extend the demised
term of the Lease, all as more particularly set out hereinbelow.

      NOW, THEREFORE, in consideration of the covenants and conditions contained
herein, Landlord and Tenant agree to amend the Lease as follows:

      1.  The  demised  term of the  Lease is  hereby  extended  four (4)  years
commencing August 1, 2008, and the demised term shall expire on July 31, 2012 at
11:59 p.m.

      2. Effective as of the Effective Date, Section 1.3. of the Lease (Tenant's
option to extend the demised  term of the Lease),  which was  inserted  into the
Lease in  paragraph 2 of the Fourth  Amendment,  and Section  2.8. of the Lease,
which was inserted into the Lease in paragraph 4 of the Fourth Amendment,  shall
be deemed void and of no further force or effect,  as the parties have agreed to
extend the demised term of the Lease  pursuant to the  provisions  of this Fifth
Amendment.

      3. Base rent payable pursuant to Sections 2.1. and 2.2. of the Lease shall
be payable  during the extended  term as follows:  for the period from August 1,
2008,  to and  including  July 31,  2012,  base rent shall be the amount of Four
Hundred   Seventeen   Thousand  Two  Hundred   Eighty  Two  and  48/100  Dollars
($417,282.48)  per annum,  payable in twelve (12) equal monthly  installments of
Thirty  Four   Thousand   Seven  Hundred   Seventy  Three  and  54/100   Dollars
($34,773.54).

      4. In addition to the base rent set forth in Section 2.1 of the Lease,  as
revised  hereinabove,  Tenant shall continue to pay all items of additional rent
pursuant to the terms of the Lease.

      5. Tenant hereby  receives a new option to further extend the demised term
of the Lease;  therefore,  the  following  new Section 1.3. is inserted into the
Lease as of the Effective Date:

                                      -1-
<PAGE>

            "Section  1.3.  Provided  that Tenant is not,  at the time  Landlord
      receives Tenant's written notice to exercise the following option, and has
      not been, in default  under any of the terms and  conditions of the Lease,
      which  default has not been cured within the  applicable  cure periods set
      forth in Article 13 of the Lease,  Tenant  shall have the option to extend
      the demised  term of the Lease for one (1)  additional  period of four (4)
      years upon the following terms and conditions:

            A. Tenant shall  exercise  the option by written  notice to Landlord
      given no later than one hundred  eighty  (180) days,  nor earlier than two
      hundred seventy (270) days, prior to the expiration of the demised term;

            B. The option term will commence on August 1, 2012, and shall extend
      for a period of four (4) years, up to and including July 31, 2016;

            C. There  shall be no further  options to extend,  there shall be no
      Landlord  inducement,  and  Landlord  shall not be required to perform any
      improvements  in the demised  premises or the building  prior to or during
      the option term;

            D. The option to extend may only be exercised by Geron  Corporation,
      provided that Geron  Corporation  may exercise the option on behalf of its
      sublessee if Geron  Corporation  has  subleased  any or all of the demised
      premises and Landlord has consented to such sublease. The option cannot be
      transferred  nor  can  it be  exercised  by  Geron  Corporation  if  Geron
      Corporation has assigned its rights under this Lease to a third party.

            E. The then current  payments for additional  rent shall continue to
      be adjusted  during the option  term  pursuant  to the  provisions  of the
      Lease;

            F. The base rent for each year of the option term shall  (subject to
      the  provisions  hereof) equal the Fair Market  Rental Value  (hereinafter
      defined). "Fair Market Rental Value" shall mean the market rent, including
      annual  increases  (if any),  being charged on the first day of the option
      term for similar space in buildings of comparable  quality as the building
      in which the demised  premises  is  situated  which are located in similar
      areas of the Cities of Menlo Park and Palo Alto. In  determining  the Fair
      Market Rental Value comparable transactions shall be considered, including
      without limitation,  length of lease term, landlord and tenant inducements
      and rent increases, if and to the extent then a part of market conditions.
      The rent on  comparable  leases  shall be adjusted to reflect the value or
      cost of such inducements  since neither Landlord nor Tenant shall have any
      obligation  to pay or  perform  any  such  inducements  (except  for  rent
      increases if applicable). For purposes of the determination of Fair Market
      Rental  Value it shall be assumed the  Landlord and Tenant are each ready,
      willing and able to enter into such a lease but are under no compulsion to
      do so.

                                      -2-
<PAGE>

            Within twenty (20) calendar days after  Tenant's  written  notice of
      exercise,  Tenant shall advise Landlord of its estimate of the Fair Market
      Rental  Value for the  demised  premises.  Landlord,  within  twenty  (20)
      calendar days  thereafter,  shall advise Tenant in writing of its estimate
      of the Fair Market Rental Value. During the next twenty (20) calendar days
      the parties  shall meet and confer for the  purpose of agreeing  upon Fair
      Market  Rental  Value.  If the parties are then unable to agree,  then the
      Fair Market Rental Value shall be determined by an appraisal as herein set
      forth and the Fair Market Rental Value as so  determined  shall be binding
      upon  Landlord  and Tenant.  Within  ninety (90)  calendar  days after the
      Tenant's  notice of  exercise,  Landlord  and Tenant shall each appoint an
      appraiser and notify the other party in writing of its choice.  Thereupon,
      the two appraisers so elected shall elect a third appraiser  within thirty
      (30) calendar days of their appointment, unless during such period the two
      appraisers  shall have  agreed upon a Fair Market  Rental  Value,  or have
      reconciled  their  appraisals to within ten percent (10%) of each other in
      which  event the  average of the two  appraisals  will be the Fair  Market
      Rental  Value,  in which  case  their  determination  shall  be final  and
      binding.  If the two  appraisers  shall be  unable  to agree  upon a third
      appraiser,  then the  Landlord and Tenant  shall  immediately  request the
      Presiding  Judge of the San  Mateo  County  Superior  Court  to make  such
      selection.  The three appraisers shall meet and confer for a period not to
      exceed  sixty (60)  calendar  days and the  determination  of Fair  Market
      Rental Value by a majority of the three shall be final and binding. In the
      event that a majority  cannot agree,  then the third  (neutral)  appraiser
      shall direct each of the party appraisers to review their appraisals for a
      period of seven (7)  calendar  days and  return to a meeting  of the three
      appraisers  within five (5) calendar days  thereafter with each respective
      party  appraiser  having  indicated  their final  appraisal of Fair Market
      Rental Value in a sealed envelope and signed by that appraiser.  The third
      appraiser  will do the same.  The envelopes will be opened in the presence
      of the three  appraisers  and the Fair  Market  Rental  Value of the party
      appraiser  which is closest to the Fair Market  Rental  Value of the third
      appraiser  will be the final Fair Market  Rental  Value and binding on the
      parties.  Each party shall bear the cost of the  appraiser  selected by it
      and the cost of the third appraiser shall be shared equally (including all
      costs  associated  with an appointment by the Superior Court of San Mateo,
      if  applicable,  regardless of which party filed the  application).  To be
      appointed  as  an  appraiser  the  person  so  appointed  shall  hold  the
      professional  designation of MAI awarded by the American Institute of Real
      Estate  Appraisers  or such  designation  as may  then  be the  preeminent
      professional designation,  hold any licenses which may then be required by
      law,  and  have at least  five (5)  years  current  experience  appraising
      commercial/light  industrial  properties  in San Mateo  County.  The third
      (neutral)  appraiser  shall not have had any personal,  social or business
      relationship  with  either  party  or  any  of its  personnel  during  the
      preceding five (5) years.

            Notwithstanding the foregoing to the contrary, in no event shall the
      base rent for each year of the option term be reduced  below the base rent
      payable by Tenant for the last year (or partial year) of the demised term.

            When the base rent for the option term is determined pursuant to the
      above  provisions,  the parties shall promptly execute an amendment to the
      Lease  stating  the base rent to be paid  during the option  term.  In the
      event  Tenant  has  retained  the  services  of a real  estate  broker  to
      represent  Tenant  during  the  negotiations  of the  option  term,  it is
      expressly  understood  that  Landlord  shall  have no  obligation  for the
      payment of all or any part of a real estate  commission or other brokerage
      fee to Tenant's real estate broker in connection  therewith.  Tenant shall
      be solely  responsible  for the payments of fees for services  rendered to
      Tenant by such broker in connection with the option term.

            G. All other terms and conditions of the option term shall be as set
      forth in the Lease, and upon exercise by Tenant of the option as set forth
      herein all  references  to the  demised  term set forth in the Lease shall
      include the extended term."

      6. It is understood  and agreed that all other terms and conditions of the
Lease shall be and remain the same. Capitalized terms herein shall have the same
meaning as in the Lease. If there is any conflict between the provisions of this
Fifth  Amendment and the provisions of the Lease,  the  provisions  contained in
this Fifth Amendment shall control.

                                      -3-
<PAGE>

      7. This Fifth  Amendment shall be construed under the laws of the State of
California. If any provision of this Fifth Amendment, or portion thereof, or the
application  thereof to any person or  circumstances  shall,  to any extent,  be
invalid or  unenforceable,  the remainder of this Fifth  Amendment  shall not be
affected  thereby and each provision of this Fifth  Amendment shall be valid and
enforceable to the fullest extent permitted by law.

      IN WITNESS  WHEREOF,  the parties have executed this Fifth Amendment as of
the date first hereinabove written.

TENANT:                                LANDLORD:
GERON CORPORATION,                     DAVID D. BOHANNON ORGANIZATION,
a Delaware corporation                 a California corporation

By   /s/ David L. Greenwood            By   /s/ Scott Bohannon
   -------------------------------       ------------------------------------
   David L. Greenwood                      Senior Vice President
   Executive Vice President and CFO

                                       By   /s/ Ernest Lotti Jr.
                                         ------------------------------------
                                            Secretary

                                      -4-

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