Document:

Exhibit 10.1 

 

SUB-LICENSE
AGREEMENT

 

This
Agreement is effective as of February 1, 2015 (the “Effective Date”).

 

BETWEEN

 

GREY’S
PAPER RECYCLING INDUSTRIES LIMITED PARTERSHIP 

A
partnership formed under the laws of the Province of Alberta

(the
“Sub - Licensor”)

 

and

 

GREYS
CORPORATION

A
corporation incorporated under the laws of the State of Delaware

(the
“Sub-Licensee”)

 

Background:

 

		A.	The Sub-Licensor has obtained from Rajan Ahluwalia the
rights to methods of production
of high quality recycled paper products using a combination of recycled paper pulp and recycled cotton to create a finished paper
product, comprising a patent application for a PROCESS FOR PRODUCING RECYCLED PAPER under PCT/CA2011/000503 and CA2,703,595, related
trade-secrets and associated know-how, including methods, techniques, specifications, procedures, information, systems, knowledge
and business processes required to practice and carry on business in the field of waste product recycling (together, the “Intellectual
Property”) under a license agreement (the "Head License”) effective January 1, 2011 which allows the
Sub-Licensor to grant sublicenses to the Intellectual Property on providing notice to Rajan Ahluwalia (the “Notice”).

  

		B.	The Sub-Licensee, intends to operate a paper recycling
business located at one or more sites
in the United States of America and seeks a sublicense to the Intellectual Property.

  

		C.	The Sub-Licensee wishes to grant a sublicense to the
Sub-Licensee.

 

NOW
THEREFORE, in consideration of the premises and the mutual covenants contained in this agreement, the parties agree:

 

		1.	DEFINITIONS

 

		(a)	“Affiliate” of any person shall with the respect to that person mean, if a corporation
any officer, director, senior employee, beneficial or registered shareholder or spouse thereof, or any corporation in which it
or any beneficial or registered shareholder owns beneficially or of records more than 10% of any class of shares, if a partnership,
any partner or officer, director, senior employee, beneficial or registered shareholder of a partner or a spouse thereof, and if
an individual all such persons as are related to him within the meaning of that term from time to time in the Income
Tax Act (Canada);

 

     

     

    

 

		(b)	“License
                                         Location” shall mean the business name and civic address designated
                                         in Schedule 1, which may be updated from time to time by the Sub-Licensee.

 

		2.	GRANT OF
LICENSE

 

		2.1	The Sub-Licensor grants to the Sub-Licensee,
                                         an exclusive sub-license to use the Intellectual Property in connection with the recycling
                                         of various waste materials, including post-consumer paper products and cotton to make
                                         use and sell products (the “Sublicense”) in the Territory defined
                                         in Section 6 below.

  

		3.	TERM OF
LICENSE

 

		3.1	The term of the License is for 10 years commencing on the Effective Date, expiring at 11:59 p.m.
on the 31st day of January 2025 (the “Term”) unless this Agreement is terminated at an earlier date
as provided in Section 14 below.

 

		4.	RENEWAL
                                         OF LICENSE

 

		4.1	Upon the expiration of the Term, and subject to performance by
the Sub-Licensor during the Term, Sub-Licensor may enter into a new license agreement with the Sub-Licensee for an additional
3 terms of 10 years each under substantially the same terms of this Agreement, and subject to the following:

 

		(a)	the Sub-Licensee shall deliver to the Sub-Licensor written notice of the Sub-Licensee’s
intent to renew not more than twelve months and not less than nine months prior to the expiry date;

 

		(b)	the Sub-Licensee shall, not less than thirty days before the Expiry Date, execute a new license
agreement, which shall be in such form as the Sub-Licensor deems acceptable, and which may contain materially different terms from
those contained in this Agreement, including an increased Fee; and

 

		(c)	at the time of the execution of the new license agreement, the Sub-Licensee shall not be in default
under this Agreement or any other agreement with the Sub-Licensor or obligation owed to Sub-Licensor, including without limitation,
any other license agreement or ancillary document, any obligation to pay: a fee, rent, interest or late charges, an audit fee or
other amount.

 

		5.	HOLDING
OVER

 

		5.1	If the Sub-Licensee continues to use the Intellectual Property after the expiration of the
                                                           Term without validly exercising an option to enter into a new license pursuant to Section 4.1, the Sub-Licensee shall be
                                                           deemed to be using the Intellectual Property under the terms and conditions of the new license agreement, on a month-to-month
                                                           basis. However, in such event, such month-to-month agreement may be terminated at any time upon ten (10) days written notice
                                                           from the Sub-Licensor. If local law requires that the Sub-Licensor give notice to the Sub-Licensee prior to the expiration of
                                                           the term, this Agreement
shall remain in effect on a month-to month basis until the Sub-Licensor has given the Sub-Licensee such notice.

 

    	 	-2-	 

     

    

  

		6.	TERRITORY
AND EXCLUSIVITY

 

		6.1	The Sub-License
                                         is only granted within the United States of America (the “Territory”).

 

		7.	TRAINING
OF EMPLOYEES BY THE SUB-LICENSEE

 

		7.1	GUIDANCE

 

The
Sub-Licensor shall disclose the Intellectual Property to the Sub-Licensee by providing guidance to the Sub-Licensee during the
Term. The Sub-Licensor may provide to the Sub-Licensee further guidance in connection with operating methods and procedures for
the proper use of the Intellectual Property from time to time and at the discretion of the Sub-Licensor, and shall facilitate access
to Rajan Ahluwalia where required for commercial implementation of the Intellectual Property.

 

		8.	INTELLECTUAL
PROPERTY

 

		8.1	INTELLECTUAL PROPERTY RIGHTS

 

		(a)	The Sub-Licensee acknowledges that Rajan Ahluwalia is the owner of the Intellectual Property. The
Sub-Licensee’s right to use the Intellectual Property is derived solely from this Agreement and is limited to the conduct
of the Business by the Sub-Licensee pursuant to and in compliance with this Agreement and all applicable specifications, standards
and operating procedures prescribed by the Sub-Licensor from time to time during the Term.

 

		(b)	Any unauthorized use of the Intellectual Property by the Sub-Licensee is deemed an infringement
of the Sub-Licensor’s rights in and to the Intellectual Property.

 

		(c)	The Sub-Licensee shall not oppose or challenge, consent to, or assist anyone else to challenge
the validity of the Intellectual Property or the Sub-Licensor’s rights therein.

 

		(d)	The Sub-Licensee acknowledges and agrees that all goodwill established by use of the Intellectual
Property by the Sub-Licensee shall accrue to Sub-Licensor for the Sub-Licensor’s exclusive benefit.

 

		(e)	Sub-Licensor reserves the right to inspect Sub-Licensee facilities, business processes, and products
to ensure Sub-Licensee is following the Sub-Licensor’s prescribed procedures and policies, and that the facilities, processes,
and products meet requisite quality standards, and to provide written notice of any non-compliance or quality defect, after which
the Sub-Licensee shall have ten (10) days
to remedy such non-compliance or quality defect, or Sub-Licensee shall be deemed to be in material breach of this Agreement subject
to Section 13 below.

  

    	 	-3-	 

     

    

  

		8.2	NOTIFICATION OF INFRINGEMENT AND CLAIMS

 

The
Sub-Licensee shall notify the Sub-Licensor as soon as practicable after learning of any apparent infringement of or challenge to
the Intellectual Property, or learning of any claim by a person of any rights in or to the Intellectual Property. The Sub-Licensee
shall not communicate with any person other than the Sub-Licensor and its legal counsel in connection with any such infringement,
challenge or claim. The Sub-Licensor shall have sole discretion to take such action as it deems appropriate and to exclusively
control any litigation or other proceeding (including, without limitation, any Patent Office proceeding) arising out of any such
infringement, challenge or claim, or otherwise relating to any of the Intellectual Property.

 

The
Sub-Licensee shall execute any and all instruments and documents, render all assistance, and do all acts and things as may, in
the opinion of the Sub-Licensor’s legal counsel, be necessary or advisable to protect and maintain the interests of the Sub-Licensor and the Intellectual Property.

 

		8.3	INDEMNIFICATION
OF THE SUB-LICENSEE

 

		(a)	The Sub-Licensor
hereby indemnifies and holds harmless the Sub-Licensee from any and all damages arising out of Sub-Licensor’s use of any
of the Intellectual Property pursuant to and in compliance
with this Agreement, for all costs reasonably incurred by the Sub-Licensee to defend any such claim brought against him or in any
such proceeding in which he is named as a party, provided that the Sub-Licensee has in a timely manner notified the Sub-Licensor
of such claim or proceeding and has otherwise complied with this Agreement.

 

		(b)	If
the Sub-Licensor, in his sole discretion, determines the Sub-Licensee shall discontinue or modify the Sub-Licensee’s
use of the Intellectual Property, the Sub-Licensor shall provide ninety (90) days written notice of the same to Sub- Licensee,
and Sub-Licensee shall discontinue or modify use of the Intellectual Property in accord with the notice. The sole obligation of
the Sub-Licensor in that event shall be to reimburse the Sub-Licensee for reasonable expenses actually incurred and necessary
to comply with the notice.

 

		9.	INTELLECTUAL PROPERTY, TRADE-SECRET, KNOW-HOW. CONFIDENTIALITY

 

		9.1	The Sub-Licensee
acknowledges that the Sub-Licensor possesses proprietary and confidential information and materials in the Intellectual Property,
including the Trade Secret, and the Know-How.

 

		9.2	The Sub-Licensor
shall designate confidential information and materials as “Confidential” and shall communicate the same to the Sub-Licensee
at the time the information and/or materials are given to the Sub-Licensee.

 

		9.3	The Sub-Licensee
shall:

 

		(a)	not
use the Intellectual Property in any
business or capacity not expressly allowed under the Agreement;

 

		(b)	protect
the confidentiality of all confidential information and materials, including but not limited to the Trade Secret and the Know-How,
during and after the Term;

 

    	 	-4-	 

     

    

 

		(c)	disclose information and materials designated as confidential, the Trade Secret and the Know-How
only to employees of the Sub-Licensee who are under a similar duty of confidentiality and have a need to know the same in the course
of operating the Business;

 

		(d)	not distribute any copy of any portion of the Intellectual Property disclosed in written form;
and

 

		(e)	adopt and implement its own procedures and standards to maintain and protect the confidentiality
of confidential information and materials, including, without limitation, restricting disclosure of the same to Sub-Licensee employees
under a similar obligation of confidentiality with a need to know in the normal course of Business.

 

		10	RELATIONSHIP
OF THE PARTIES

 

		10.1	INDEPENDENT CONTRACTORS

 

The
parties agree that the Sub-Licensor and the Sub-Licensee shall be independent contractors and that nothing in this Agreement makes
either party a general or special agent, fiduciary, legal representative, subsidiary, joint venture, partner, employee or servant
of the other for any purpose.

 

		10.2	USE OF INTELLECTUAL PROPERTY

 

		(a)	The Sub-Licensee acknowledges that the Sub-Licensor does not authorize or empower the Sub-Licensee
to use the Intellectual Property except as provided by this Agreement, and the Sub-Licensee acquires no underlying rights in the
Intellectual Property excepting the rights to use the Intellectual Property as provided herein.

 

		(b)	The Sub-Licensee shall not promise, commit, register, otherwise encumber the Intellectual Property
in signing any contract, lease, mortgage, purchase agreement, negotiable instrument or other legal obligation, or in any manner
that may result in liability of the Sub-Licensor for any indebtedness or obligation of the Sub-Licensee.

 

		11	INDEMNIFICATION
OF SUB-LICENSOR

 

		11.1	The Sub-Licensee
                                         hereby indemnifies and holds harmless the Sub-Licensor, Rajan Ahluwalia and all Affiliates,
                                         employees, agents, assignees and other sub-licensees, if any, (collectively, the “Indemnities”)
                                         harmless from and against and will reimburse them for all liabilities, obligations, actual
                                         and consequential damages, taxes, costs and losses, including without limitation costs
                                         of judgment or settlement, accountants' and lawyers’ fees, on a solicitor and client
                                         basis, expert witness fees, costs of investigation and proof of facts, court costs, other
                                         litigation expenses and travel and living expenses, reasonably incurred by any of them
                                         in connection with any claim, allegation or proceeding arising out of the Sub-Licensee’s
                                         operations or activities, brought against any of the Indemnities, or in which any of
                                         them is named or threatened to be named as a party. The Sub-Licensee shall pay and satisfy
                                         any judgment or settlement that arises out of any such claim or proceeding.

 

    	 	-5-	 

     

    

  

		11.2	The Sub-Licensor may choose to defend any such claim or proceeding arising from the Sub-Licensee’s
authorized use of the intellectual Property. Without limiting the generality of the foregoing, if the Sub-Licensor is made a party
to any lawsuit or other legal action in connection with the activities of the Sub-Licensee, Affiliates of Sub-Licensee, or sublicensee,
the Sub-Licensor may, at its sole option, either notify the Sub-Licensee that the Sub-Licensee shall be responsible for diligently
and promptly pursuing such matter at the Sub-Licensee’s sole expense, or the Sub-Licensor may hire counsel and from time
to time advise the Sub-Licensee of all costs, fees and expenses incurred, including, without limitation, lawyer’s fees (on a solicitor
and client basis), accountants’ fees, expert witness fees, costs of investigation and proof of facts, court costs and other litigation
expenses and travel and living expenses, which arise in connection therewith, and the Sub- Licensee shall promptly reimburse the
Sub-Licensor for all such expenses. The indemnities and assumptions of liabilities and obligations under this Agreement shall continue
in full force and effect subsequent to and notwithstanding the termination of this Agreement.

 

		12	FEES

 

		12.1	ROYALTY FEE

 

The
Sub-Licensee shall pay to the Sub-Licensor a Royalty of TEN PERCENT (10%) of Net Revenue generated by the Sub-Licensee by use of
the Intellectual Property.

 

		(a)	For the purposes of this section, Net Revenue means the
total sum actually received by the Sub-Licensor in respect of all sales of all merchandise, services of any kind and character
and all other receipts of business of the Sub-Licensee, less interest, taxes, depreciation, amortization expenses, shipping, taxes,
returns, cost of production, rebates actually paid and allowances for bad debt actually accounted for,

 

		12.2	REMITTANCE OF PAYMENT

 

The
Sub-Licensee will remit payment of the Royalty on a quarterly basis, the first quarter commencing on the Effective Date of this
agreement and subsequent quarters beginning first day of each January, April, July and October during the life of the Agreement.

 

		(a)	Reporting
of Financial Information

 

Gross
Profits for each quarter shall be reported to the Sub-Licensor in writing within 15 days of the end of the quarter. The Royalty
shall be paid within 30 days of the end of each quarter.

 

		12.3	AUDIT RIGHTS

 

To
ensure the accuracy of the Net Revenue calculations as set out in Section 12.1 above, the Sub-Licensor shall have the right, at
the Sub-Licensor’s cost, to audit the Sub-Licensee. If the auditors of the Sub-Licensor find a shortfall in respect of the
amount that should have been paid to the Sub-Licensor, the Sub-Licensee will also be liable to the full cost of the audit as well
as the shortfall plus any interest accrued thereon as set out in Section 12.4 below.

 

    	 	-6-	 

     

    

  

		12.4	INTEREST ON LATE PAYMENTS

 

All
Fees and other amounts which the Sub-Licensee owes to the Sub-Licensor shall bear interest from the date due until they are fully
paid at the rate of two percent (2%) per month, provided that in the event such rate exceeds the maximum rate allowable by applicable
law, such amounts shall bear interest at such maximum rate. The Sub- Licensee acknowledges that the terms of this paragraph shall
not constitute the Sub- Licensor’s agreement to accept such payments after the same are due or a commitment by the Sub-Licensor
to extend credit to, or otherwise finance the Sub-Licensee. The Sub-Licensee’s failure to pay any amount when due shall constitute
a Material Breach of this Agreement notwithstanding the terms of this paragraph.

 

		12.5	APPLICATION OF PAYMENTS

 

The
Sub-Licensor, in its sole discretion, shall apply payments received from the Sub-Licensee to unpaid Fees, unpaid interest thereon,
other indebtedness from the Sub-Licensee to the Sub-Licensor for other indebtedness, interest on any other Sub-Licensee indebtedness,
and unpaid insurance premiums due by the Sub-Licensee in respect of the Business.

 

		12.6	SECURITY FOR SUB-LICENSEE’S OBLIGATIONS

 

As
continuing security for the Sub-Licensee’s obligations under this Agreement, the Sub-Licensee grants to the Sub-Licensor
a security interest over all personal property and after acquired personal property of the Sub-Licensee used in connection with
the Business, and consents to the Sub-Licensor registering such security interest in the jurisdiction in which the Business is
located.

 

		13	OPERATING
                                         STANDARDS

 

		13.1	COMPLIANCEWITH LAWS, INSURANCE AND NOTIFICATION OF ACTIONS

 

The
Sub-Licensee shall, throughout the Term, obtain and maintain in force all required licenses, permits and certificates to operate
the Business and shall maintain adequate insurance on Sub-Licensee property and premises so as to reasonably protect ongoing operations
of the Business. The Sub-Licensee shall notify the Sub-Licensor in writing, within five (5) days of the Sub-Licensee’s first
notice thereof, of any cancellation of insurance policy or license, or issuance of an order, writ, injunction, award or decree
of any court, agency or other governmental instrumentality which may adversely affect the operation or financial condition of the
Sub-Licensee or the Sub-Licensor.

 

		14	TERMINATION

 

		14.1	In the event of a Material Breach by the Sub-Licensee, that is unremedied as provided herein, the
Sub-Licensor may upon written notice to the Sub-Licensee, immediately terminate this Agreement, pursue all remedies under this
Agreement, and pursue all other remedies available to it. Termination of this Agreement shall not relieve the Sub-Licensee of
any unfulfilled obligations created under this Agreement.

 

		(a)	“Material Breach” means:

 

    	 	-7-	 

     

    

 

		(i)	If the Sub-Licensee abandons, surrenders, transfers control
of or fails to actively operate the Business;

 

		(ii)	If the Sub-Licensee, an Affiliate of Sub-Licensee makes
unauthorized use of the Intellectual Property or discloses confidential information or material of the Sub-Licensor, including
but not limited to the Trade Secret and the Know-How;

 

		(iii)	If the Sub-Licensee fails to pay when due any amount owing
to the Sub-Licensor or an Affiliate pursuant to the terms of this Agreement;

 

		(iv)	If the Sub-Licensee fails to pay when due any amount owing
to any supplier or other party with whom the Sub-Licensor deals;

 

		(v)	If the Sub-Licensee becomes insolvent, if a receiver is
appointed to take possession of the Business or the Sub-Licensee’s property or any part thereof, if the Sub-Licensee makes
a general assignment for the benefit of creditors, becomes bankrupt, or if a receiver, receiver-manager or trustee in bankruptcy
or similar officer, temporary or permanent, is appointed to take charge of any of the Sub-Licensee’s property, if dissolution
proceedings are commenced by or against the Sub-Licensee, or if a judgment is obtained against the Sub-Licensee which remains
unsatisfied for a period of more than thirty days after all rights of appeal have expired or been exhausted;

 

		(vi)	If the Sub-Licensee makes any default under any mortgage, agreement of or for sale,
                                                                                    debenture, or deed of trust which results in commencement or taking of any action to cancel said agreement of sale, or to
                                                                                    foreclose said mortgage, agreement for sale, debenture, or deed of trust, or appoint a receiver or receiver-manager of the
                                                                                    Business;

 

		(vii)	If the Sub-Licensee assigns its interest in this Agreement
without the prior written consent of the Sub-Licensor;

 

		(viii)	If the Sub-Licensee fails to comply with any other provision
of this Agreement or any mandatory specification standard or operating procedure prescribed by the Sub-Licensor and does not correct
such failure within ten (10) days after receipt of written notice of such failure to comply, including the Sub-Licensor’s
standards per Subsection 8.1(e) above; or

 

    	 	-8-	 

     

    

 

		15	RIGHTS
                                         OF THE SUB-LICENSOR AND OBLIGATIONS OF THE SUB-LICENSEE UPON TERMINATION OR EXPIRATION
                                         OF THE LICENSE

 

		15.1	PAYMENT
OF AMOUNTS OWED TO THE SUB-LICENSOR

 

The
Sub-Licensee will pay to the Sub-Licensor within fifteen (15) days after the date of termination of this Agreement, or such later
date as any amount due to the Sub-Licensor is determined by the Sub-Licensor, all fees owed by Sub-Licensee to the Sub-Licensor
or its Affiliates, interest due to the Sub-Licensor on any of the foregoing and all other amounts owed to the Sub-Licensor which
are then unpaid.

 

		15.2	DISCONTINUANCE

 

In
the event of the termination of this Agreement, the Sub-Licensee shall immediately discontinue use of the Intellectual Property,
including the Trade Secret and Know-How, shall terminate all sublicenses, and shall not thereafter operate or do business under
any name or in any manner than might tend to give the general public the impression that it is, either directly or indirectly,
associated, affiliated, licensed by or related to Intellectual Property. Further, the Sub-Licensee shall:

 

		(a)	not, directly
or indirectly, at any time after termination of this Agreement, in any manner:

		(i)	identify
himself or any related business or Affiliate as a current or former Sub-Licensee of the Intellectual Property, or as otherwise
associated with the Sub-Licensor;

		(ii)	use
the Intellectual Property;

		(iii)	use
any trade name, trade-mark or service mark or other commercial symbol that suggests or indicates a connection or association with
the Sub-Licensor; or

		(iv)	do
anything which would indicate that the Sub-Licensee is or ever was the a Sub-Licensee of the Intellectual Property.

 

		(b)	at the option
of the Sub-Licensor, promptly sell to the Sub-Licensor, at a price equal to the Sub-Licensee’s actual cost thereof, all or
any part of the products on hand which contain any of the Intellectual Property;

 

		(c)	promptly surrender
to the Sub-Licensor all training and instructional
materials, invoices and other materials and all copies thereof containing any of the Intellectual Property;

 

		(d)	promptly take
all such action as may be necessary or appropriate to cancel all declarations of trade name or equivalent registrations or filings
relating to its use of any of the Intellectual Property; and

 

		(e)	furnish to the
Sub-Licensor, within thirty days after the date of any termination of this Agreement, evidence satisfactory to the Sub-Licensor
of the Sub-Licensee’s compliance with the foregoing obligations.

 

    	 	-9-	 

     

    

 

		15.3	POWER OF ATTORNEY

 

Notwithstanding
the termination of this Agreement, the Sub-Licensor may, if the SubLicensee does not do so, execute in the Sub-Licensee’s name
and on the Sub- Licensee’s behalf any and all documents necessary in the Sub-Licensor’s judgment to end the use of the Intellectual
Property by the Sub-Licensee, and the Sub-Licensor and any officer of the Sub-Licensor are hereby irrevocably appointed and designated
as the Sub-Licensee’s attorney-in-fact so to do.

 

		15.4	CONTINUING OBLIGATIONS

 

All
obligations of the Sub-Licensor and the Sub-Licensee which expressly or by their nature survive the termination of this Agreement
shall continue in full force and effect subsequent to and notwithstanding the termination of this Agreement and until they are
satisfied in full or by their nature expire. The Sub-Licensee’s confidentiality obligations arising in subsection 9.1 shall
survive termination of this Agreement, and shall continue in perpetuity, or until such time as all Know-How and Intellectual Property
are generally and freely available to the public, through no act of the Sub-Licensee.

 

		16	ASSIGNMENT,
TRANSFER AND ENCUMBRANCE

 

		16.1	BY THE SUB-LICENSOR

 

The
Sub-Licensor may assign or transfer its obligations under this Agreement or its interest in the Intellectual Property in whole
or in part to an affiliate or to a third party. Any assignment by the Sub-Licensor shall serve to the benefit of any assignee,
transferee or other legal successor in interest or title, provided that no such assignment, transfer, pledge or hypothecation shall
materially affect the rights and privileges granted to the Sub-Licensee under this Agreement.

 

		16.2	BY THE SUB-LICENSEE

 

The
Sub-Licensee agrees not to transfer, sublicense, or encumber its interest in this Agreement or the rights granted hereunder without
the written consent of Rajan Ahluwalia and Sub-Licensor.

 

		16.3	SUB-LICENSEE ASSIGNMENT OF OWNERSHIP INTEREST IN SUB-LICENSEE

 

The
Sub-Licensee acknowledges that the rights and duties created by this Agreement are personal to the Sub-Licensee, and that the Sub-Licensor
has entered into this Agreement relying upon the individual or collective character, skill, aptitude, attitude, business ability
and financial capacity of the Sub-Licensee, its directors, officers and shareholders, if any. Therefore, except as expressly provided
in this Agreement none of the Sub-Licensee, its directors, officers, or shareholders, if any, may directly or indirectly assign,
sell, subdivide, sub-license or otherwise transfer or encumber the Sub-Licensee including, without limitation, by merger or consolidation,
and by issuance of additional securities representing an ownership interest in the Sub-Licensee, without the prior written approval
of the Sub-Licensor. Any such assignment or transfer without such approval shall constitute a Material Breach, shall be deemed
invalid and of no force or effect, and shall not convey any rights to or interest in this Agreement, the Business or the Sub-Licensee.

 

    	 	-10-	 

     

    

 

		16.4	CONDITIONS
FOR APPROVAL OF ASSIGNMENT OF AGREEMENT

 

The
Sub-Licensor shall not unreasonably withhold its approval of an assignment of this Agreement, provided that:

 

		(a)	the
Sub-Licensee is in full compliance with this Agreement;

 

		(b)	there is no Material
Breach or uncured event of default under this Agreement;

 

		(c)	the proposed
assignee and its shareholders, if any, in the opinion of the Sub-Licensor is of good moral character, has sufficient business
experience, and otherwise meets the Sub-Licensor’s then applicable standards for new sublicensees;

 

		(d)	all Sub-Licensee
obligations under this Agreement have been assumed by the assignee;

 

		(e)	the assignee
and its shareholders, if any, have executed the form of license agreement and such ancillary agreements as are then acceptable
by the Sub-Licensor to grant the license, which shall provide for Sub-Licensee's payment of a Royalty Fee equal to or greater
than the Royalty Fee;

 

		(f)	the Sub-Licensee
to have executed a general release, in a form satisfactory to the Sub-Licensor, of any and all claims against the Sub-Licensor
and its Affiliates, employees and agents; and

 

		(g)	the Sub-Licensor
to have approved the material terms and conditions of such assignment, including, without limitation, that the price and terms
of payment are not so burdensome as to adversely affect the future operations of the assignee in compliance with a license agreement
and ancillary agreements then acceptable to the Sub-Licensor.

 

		17	REPRESENTATIONS,
WARRANTIES AND ACKNOWLEDGMENTS OF SUB-LICENSEE

 

		17.1	The
Sub-Licensee represents and warrants to the Sub-Licensor as follows:

 

		(a)	The Sub-Licensee
has had ample time and opportunity to consult with advisers of his own choosing prior to signing this Agreement, or hereby waives
the right to do so;

 

		(b)	The execution
of this Agreement by the Sub-Licensee will not violate or breach the terms of any other agreement or commitment to which the Sub-Licensee
is a party;

 

		(c)	The individual
executing this Agreement on behalf of the Sub-Licensee is duly authorized to do so, and upon its execution this Agreement shall
constitute a legal, valid and binding obligation of the Sub-Licensee; and

 

		(d)	The Sub-Licensee
and each of its partners or shareholders, as the case may be, if the Sub-Licensee is a partnership or a corporation, have read
fully this Agreement
and all related agreements, fully understand the terms and the import of the same, and each is capable of complying and will comply
therewith.

 

    	 	-11-	 

     

    

 

		17.2	The Sub-Licensee acknowledges that, except as may otherwise
specifically be set forth in this Agreement, no representations, promises, guarantees or warranties of any kind are made or have
been made by the Sub-Licensor or by any person representing himself or herself as an authorized agent or representative of the
Sub-Licensor to induce the Sub-Licensee to execute this Agreement.

 

		17.3	The Sub-Licensee agrees that any further development of
the Intellectual Property performed by the Sub-Licensee is the property of the Rajan Ahluwalia, and the Sub-Licensee waives any
moral right.

 

		18	REPRESENTATIONS,
WARRANTIES AND COVENANTS OF SUB-LICENSOR

 

		18.1	DISCLOSURE SERVICE

 

The
Sub-Licensor agrees to disclose to the Sub-Licensee the intellectual Property, including the Trade Secret and Know-How
necessary to exploit the entire License granted, without further cost to the Sub-Licensee.

 

		18.2	SUB-LICENSOR’S RESTRICTION

 

The
Sub-Licensor agrees that this sublicense is the exclusive and only license granted by the Sub-Licensor in the United States of
America, and the Sub-Licensor shall not during the Term, unless sooner terminated as provided, grant any licence to the Intellectual
Property to any person, firm or corporation within the Unites States of America.

 

		18.3	WARRANTY

 

The
Sub-Licensor warrants that it has the right to grant this Sublicense, and that there is no outstanding licence granted by it regarding
the Intellectual Property which would conflict with the license granted to the Sub-Licensee.

 

		18.4	NON-WAIVER OF MORAL RIGHTS

 

To
the extent the Intellectual Property comprises work in which copyright subsists, the Sub-Licensor confirms it has not and does
not waive any moral right.

 

		19	GENERAL

 

		19.1	SEVERABILITY AND SUBSTITUTION OF VALID PROVISIONS

 

Except
as expressly provided in this Agreement, each provision of this Agreement shall be considered severable from all other provisions
therein. If any provision of this Agreement is held to be invalid, contrary to or in conflict with any applicable present or future
laws or regulations, in a ruling issued by any court, agency or tribunal with competent jurisdiction in a proceeding to which the
Sub-Licensor is a party and the Sub-Licensor is unable or has elected not to appeal such ruling, such ruling shall not impair
the operation of, or have any other effect upon all other provisions of this Agreement, which shall continue to be have full force
and effect and bind the parties to this Agreement. Any portion so ruled to be invalid shall be deemed not to be a part of this
Agreement from the date the time for appeal if any, from such ruling expires. In the event the Sub-Licensee is not a party to the
proceeding in which such ruling is made, any portion so ruled to be invalid shall be deemed not to be a part of this Agreement
upon the Sub-Licensee’s receipt of a notice of non-enforcement thereof from the Sub- Licensor.

 

    	 	-12-	 

     

    

 

		17.1	OVERRIDING LAW

 

If
any applicable law or rule of any jurisdiction requires a greater prior notice of the termination of or refusal to renew this Agreement
than is required under this Agreement, the taking of some other action not required under this Agreement, or if under any applicable
law or rule of any jurisdiction any provision of this Agreement or any specification, standard or operating procedure prescribed
by the Sub-Licensor is invalid or unenforceable, the prior notice or other action required by such law or rule shall be substituted
without further action by any party for the comparable provisions of this Agreement provided that the Sub-Licensor shall have the
right in its sole discretion, to modify such invalid or unenforceable provision, specification, standard or operating procedure
to the extent required to be valid and enforceable. The Sub-Licensee will be bound by the maximum duty permitted by the law which
is subsumed within the terms of any provision of this Agreement or any specification, standard or operating procedure prescribed
by the Sub-Licensor in the event a court of competent jurisdiction strikes or reduces the scope of all or any part of such provisions,
specification, standard or operating procedure. Such modifications to this Agreement shall be effective only in such court's jurisdiction,
unless the Sub-Licensor elects to give them greater applicability. In all other jurisdictions this Agreement shall be enforced
as originally made and entered into.

 

		17.2	APPROVAL

 

Whenever
this Agreement requires the Sub-Licensor’s prior approval or consent, the Sub-Licensee shall make a timely written request and
such approval shall be obtained in writing.

 

		17.3	WAIVER

 

No
failure or delay on the part of the Sub-Licensor to exercise his right of termination or cancellation nor any default by the Sub-Licensee
shall be construed to prejudice the Sub-Licensor’s right of termination or cancellation for default or for any other subsequent
defaults.

 

		17.4	FORCE MAJEURE

 

Neither
the Sub-Licensor nor the Sub-Licensee shall be liable for loss or damage or deemed to be in breach of this Agreement if it exercises
its best efforts to perform its obligations under this Agreement provided that its failure to perform obligations results from
transportation shortages, inadequate supply of labour, material or energy, or the voluntary foregoing of the right to acquire or
use any of the foregoing in order to accommodate or comply with the orders, requests, regulations, recommendations or instructions
of any federal, state or municipal government or any department or agency thereof, compliance with any law, ruling, order, regulation,
requirement or instruction of any federal, state or municipal government or any department or agency thereof, acts of God, acts
or omissions of the other party, or fires, strikes, embargoes, war, or riot. Any delay resulting from any of said causes shall
extend performance accordingly or excuse performance in whole or in part, as may be necessary.

 

    	 	-13-	 

     

    

 

		17.5	SUB-LICENSEE MAY NOT WITHHOLD PAYMENTS

 

The
Sub-Licensee will not, on grounds of the alleged non-performance by the Sub-Licensor of any of its obligations under this Agreement,
withhold payment of any fee amounts due to the Sub-Licensor or any Affiliate of the Sub-Licensor for any amounts due to the Sub-Licensor
or any Affiliate of the Sub-Licensor.

 

		17.6	SPECIFIC PERFORMANCE AND INJUNCTIVE RELIEF

 

The
Sub-Licensee acknowledges that if the Sub-Licensee breaches this Agreement or continues to use the Know-How or any of the Intellectual
Property at any time when the Sub-Licensee is not legally entitled to do so, money damages will not adequately remedy the damages
suffered by the Sub-Licensor. Therefore, the Sub-Licensee expressly agrees that the Sub-Licensor may, in addition to any other
available remedies, obtain without bond, but upon due notice, an injunctive or temporary restraining order to terminate or prevent
the continuation of any existing default or violation and to prevent the occurrence of any threatened default or violation by the
Sub-Licensee.

 

		17.7	MINIMUM ESTIMATE OF DAMAGES

 

In
the event of a breach of this agreement, the agreed pre-estimate of damages is $500,000.00 in United States currency per breach
which will be payable to the Sub-Licensor on any finding of liability by the Sub-Licensee for breach and unauthorized use of the
Intellectual Property.

 

		17.8	RIGHTS OF PARTIES ARE CUMULATIVE

 

The
rights and remedies of the Sub-Licensor and the Sub-Licensee under this Agreement are cumulative and no exercise or enforcement
by the Sub-Licensor or the Sub-Licensee of any right or remedy under this Agreement shall preclude the exercise or enforcement
by the Sub-Licensor or the Sub-Licensee of any other right or remedy under this Agreement or which the Sub-Licensor or the Sub-Licensee
is entitled by law to enforce.

 

		17.9	COSTS AND ATTORNEY FEES

 

If
a claim for amounts owed by the Sub-Licensee to the Sub-Licensor or its affiliate is asserted in any legal proceeding before a
court of competent jurisdiction or arbitrator, or if the Sub-Licensor or the Sub-Licensee is required to enforce this Agreement
in a judicial or arbitration proceeding, the party prevailing in such proceeding shall be entitled to reimbursement of its costs,
including reasonable accounting and legal fees on a solicitor and client basis.

 

    	 	-14-	 

     

    

 

		17.10	JURISDICTION

 

This
Agreement shall be governed by and construed in accordance with the laws of the Province of Alberta and the Sub-Licensee irrevocably
submits and attorns to the laws and courts of such jurisdiction and waives any objection or defence he may have with respect to
such jurisdiction or courts.

 

		17.11	BINDING
EFFECT

 

Except
as otherwise provided in this Agreement, this Agreement is binding upon the parties hereto and their respective executors, administrators,
heirs and assigns, except as otherwise provided in this Agreement.

 

		17.12	MODIFICATION

 

This
Agreement may not be modified or amended except by written agreement signed by both the Sub-Licensee and the Sub-Licensor.

 

		17.13	ENTIRE
AGREEMENT

 

This
Agreement constitutes the entire agreement of the parties regarding the Intellectual Property, and there are no other oral or written
understandings or agreements between the Sub-Licensor and the Sub-Licensee relating to the subject matter of this Agreement.

 

		17.14	HEADINGS

 

The
headings of the sections and paragraphs of this Agreement are for convenience only and do not define, limit or construe the contents
of such sections or paragraph.

 

		17.15	JOINT
AND SEVERAL OBLIGATIONS

 

If
two or more persons are at any time the Sub-Licensee
under this Agreement their obligations and liabilities to the Sub-Licensor shall be joint and several.

 

		17.16	TIME
IS OF ESSENCE

 

Time
is of the essence of this Agreement and in the performance of each and every term and provision hereof.

 

		17.17	EXECUTION
IN COUNTERPARTS

 

This
Agreement may be executed in any number of counterparts each of which shall be deemed to be an original as against any party whose
signature appears thereon, and all of
which shall together constitute one and the same instrument. This Agreement shall become binding when one or more counterparts
hereof, individually or taken together, shall bear the signatures of all of the parties reflected hereon as the signatories. Any
photocopy of this Agreement, with all signatures reproduced on one or more sets of signature pages, shall be considered for all
purposes as if it were an executed counterpart of this Agreement.

 

    	 	-15-	 

     

    

 

		17.18	NUMBER
OF DAYS

 

Except
as otherwise expressly provided in this Agreement, all days, including Saturdays, Sundays and holidays, shall be counted in computing
the number of days for purposes of this Agreement. Nevertheless, if the final day of any time period falls on a Saturday, Sunday
or holiday, then the final day shall be deemed to be the next day which is not a Saturday, Sunday or holiday.

 

		17.19	NOTICES

 

All
written notice permitted or required to be delivered by the provisions of this Agreement shall be deemed so delivered at the time
delivered by hand addressed to the party to be notified at its most current principal business address of which the notifying party
has been notified.

 

		17.20	PAYMENTS

 

All
payments required by this Agreement shall be directed to the Sub-Licensor at the address of the Sub-Licensor or at such other address
as the Sub-Licensor may from time to time notify the Sub-Licensee, or to such other persons and places as the Sub-Licensor may
direct from time to time. Any required payment not actually received by the Sub-Licensor during regular business hours on the date
due shall be deemed delinquent.

 

		17.21	SUBMISSION
OF AGREEMENT

 

The
submission of this Agreement does not constitute an offer, and this Agreement shall become effective only upon the execution thereof
by the Sub-Licensor and the Sub-Licensee. This Agreement shall not be binding on the Sub-Licensor unless and until it shall have
been accepted and signed by an authorized signatory of the Sub- Licensor.

 

IN
WITNESS WHEREOF, the parties have executed this Agreement as of the Effective Date.

 

	 	GREY’S PAPER RECYCLING INDUSTRIES LIMITED
    PARTNERSHIP
	 	 
	 	Per:	 	 
	 	 	c/s	 
	 	 
	 	GREYS CORPORATION
	 	 
	 	Per:	 	 

 

    	 	-16-	 

     

    

 

SCHEDULE
1

 

The
License Location shall be:

 

		1.	GREYS CORPORATION

		a.	Inc. Plan (USA)

Trolley
Square

Suite 20 C

Wilmington,
Delaware 19806 (County of New Castle)

 

    	 	-17-Exhibit

October 1, 2015

Macquarie US Trading LLC
125 West 55 Street
New York, NY 10019
Attention:  Arvind Admal (Arvind.Admal@macquarie.com)
David Anekstein  (David.Anekstein@macquarie.com)

		
	RE:
	Amortization Grid

Ladies and Gentlemen:

Reference is made to that certain Credit Agreement, dated as of July 9, 2014 (as amended, supplemented, amended and restated or as otherwise modified from time to time, the “Credit Agreement”), among Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (the “Borrower”), the lenders from time to time party thereto, and Macquarie US Trading LLC, as Administrative Agent.  Capitalized terms not otherwise defined herein shall have the meanings ascribed to them in the Credit Agreement.
The Borrower hereby requests that the amortization grid set forth in Section 2.04 of the Credit Agreement be amended and restated in its entirety to read as follows:
	
		
	Date
	Amount

	Closing Date to October 31, 2015
	$0.00

	November 1, 2015
	$15,000,000

	January 1, 2016
	$15,000,000

	April 1, 2016
	$15,000,000

	July 1, 2016
	$15,000,000

	October 1, 2016
	$60,000,000

	January 1, 2017
	$60,000,000

	April 1, 2017
	$60,000,000

	Maturity Date
	$60,000,000

In connection with such request, the Borrower certifies as follows:
(a)    The Borrower has the corporate or other organizational power and authority to execute, deliver and perform the terms and provisions of this letter agreement (the “Letter”) and has taken all necessary corporate action to authorize the execution, delivery and performance by it of this Letter.  The Borrower has duly executed and delivered the Letter, and the Letter constitutes its legal, valid and binding obligation enforceable in accordance with its terms, 

EAST\107271627.1 

except to the extent that the enforceability thereof may be limited by applicable bankruptcy, insolvency, moratorium and other similar laws affecting secured parties generally and principles of equity.
(b)    The execution, delivery and performance by the Borrower of this Letter, has been duly authorized by all necessary corporate or other organizational action, and does not and will not (a) contravene the terms of its Organization Documents; (b) conflict with or result in any breach or contravention of, or the creation of any Lien under, or require any payment to be made under (i) any Material Contract to which the Borrower is a party or affecting the Borrower or the properties of the Borrower or any of its Subsidiaries or (ii) any order, injunction, writ or decree of any Governmental Authority or any arbitral award to which the Borrower or its property is subject; or (c) violate any applicable Law.
 (c)    No Default has occurred and is continuing or would result from the consummation of the transactions contemplated by this Agreement or any other Loan Document. 
Except as expressly set forth herein, this Letter shall not by implication or otherwise limit, impair, constitute a waiver of or otherwise affect the rights and remedies of the Lenders or the Administrative Agent under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in any way affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other provision of the Credit Agreement or of any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect.  Nothing herein shall be deemed to entitle the Borrower to a consent to, or a waiver, amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document in similar or different circumstances.
This Letter shall constitute a “Loan Document” for all purposes of the Credit Agreement and the other Loan Documents.  THIS LETTER SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.  This Letter may be executed in counterparts (and by different parties hereto on different counterparts), each of which shall constitute an original, but all of which when taken together shall constitute a single contract.  Delivery of any executed counterpart of a signature page of this Letter by telecopy or email transmission (including by “.pdf” or “.tif” electronic format) shall be effective as delivery of a manually executed counterpart of this Letter.
By executing below, the signatories hereto agree to the amendment set forth herein.

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Sincerely,
	
		
	Vertex Pharmaceuticals Incorporated

	 
	 

	/s/ Jeffrey Leiden

	By:
	Jeffrey Leiden

	Title:
	Chief Executive Officer

	 
	 

	/s/ Ian Smith

	By:
	Ian Smith

	Title:
	Chief Financial Officer

	 
	 

ACKNOWLEDGED AND AGREED:
	
		
	MACQUARIE US TRADING LLC,  as Administrative Agent

	 
	 

	/s/ Joshua Karlin

	By:
	Joshua Karlin

	Title:
	Authorized Signatory

	 
	 

	/s/ Anita Chiu

	By:
	Anita Chiu

	Title:
	Associate Director

	 
	 

	MACQUARIE CAF LLC

	 
	 

	/s/ D. Price/ A. Hennedige

	By:
	D. Price/ A. Hennedige

	Title:
	Authorized Signatories

	 
	 

	APPOLLO CREDIT FUNDING I LTD

	 
	 

	By:
	Apollo ST Fund Management LLC, its collateral manager

	 
	 

	/s/ Joseph Moroney

	By:
	Joseph Moroney

	Title:
	Authorized Signatory

	 
	 

	 
	 

EAST\107271627.1 

	
		
	APPOLLO LINCOLN FIXED INCOME FUND, L.P.

	 
	 

	By:
	Apollo Lincoln Fixed Income Management LLC, its collateral manager

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

	 
	 

	APPOLLO TR OPPRTUNISTIC, LTD.

	 
	 

	By:
	Apollo Total Return Master Fund, L.P., its member Appollo Total Return Advisors, L.P., its General Partner Apollo Total Return Advisors GP, LLC, its General Partner

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

	 
	 

	MIDCAP FUNDING V TRUST (formerly known as MidCap Funding V, LLC

	 
	 

	By:
	Apollo Capital Management, L.P., its investment manager

	 
	 

	By:
	Apollo Capital Management, GP, LLC, its general partner

	 
	 

	/s/ Howard Widra

	By:
	Howard Widra

	Title:
	Authorized Signatory

EAST\107271627.1 

	
		
	HIGHBRIDGE AIGUILLES ROUGES SECTOR B INVESTMENT FUND, L.P.

	 
	 

	By:
	Highbridge Principal Strategies, LLC

	 
	 

	/s/ Vikas Keswani

	By:
	Vikas Keswani

	Title:
	Managing Director

	 
	 

	APOLLO ALTERNATIVE CREDIT ABSOLUTE RETURN FUND L.P.

	 
	 

	By:
	Apollo Alternative Credit Absolute Return Management LLC, its Investment Manager

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

EAST\107271627.1 

EXECUTION COPY

SECOND AMENDMENT TO CREDIT AGREEMENT
SECOND AMENDMENT TO CREDIT AGREEMENT (this “Amendment”), dated as of  October 23, 2015 (the “Amendment Effective Date”), to the  CREDIT AGREEMENT, dated as of July 9, 2014 (as the same may be amended, restated, amended and restated, supplemented or otherwise modified from time to time, the “Credit Agreement”), among Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (the “Borrower”), the lenders from time to time party thereto (collectively, the “Lenders” and individually each a “Lender”), the guarantors party thereto from time to time (the “Guarantors”) and Macquarie US Trading LLC, as Administrative Agent (the “Administrative Agent’).
W I T N E S S E T H:
WHEREAS, pursuant to the Credit Agreement, the Lenders have agreed to make, and have made certain loans and extensions for credit to the Borrower;
WHEREAS, the Borrower has requested that certain provisions of the Credit Agreement be amended as set forth herein; 
WHEREAS, the Administrative Agent and Lenders are willing to agree to such amendments, in each case on the terms set forth herein; and
WHEREAS, the Lenders that execute and deliver this Amendment constitute all of the Lenders.
NOW THEREFORE, in consideration of the premises and mutual covenants hereinafter set forth, the parties hereto agree as follows:

SECTION 1.Defined Terms; References.  Unless otherwise defined herein, terms defined in the Credit Agreement and used herein shall have the meanings given to them in the Credit Agreement.  Each reference to (x) “hereof”, “hereunder”, “herein” and “hereby” and each other similar reference and each reference to “this Agreement” and each other similar reference contained in the Credit Agreement and (y) “thereof”, “thereunder”, “therein” and “thereby” and each other similar reference and each reference to the Credit Agreement and each other similar reference contained in the other Loan Documents shall, in each case, as of the Amendment Effective Date, refer to the Credit Agreement as amended hereby.
SECTION 2.    Amendments to the Credit Agreement.  The Credit Agreement is, effective as of the Amendment Effective Date, hereby amended as follows:
2.1.      The defined term “Kalydeco Product US and Foreign Revenue” in Section 1.01 of the Credit Agreement is amended and restated in its entirety to read as follows:  
“Kalydeco Product US and Foreign Revenue” means, with respect to any date of determination, total revenue from sales of the Kalydeco Product derived from customers located in the United States and in other jurisdictions over the trailing twelve month period ending on such date of determination, which revenue, if consisting of currency other than US Dollars, will be calculated using the foreign 

EAST\110676466.2 

exchange rates prevailing as of the date of determination (or, in the event Kalydeco Product US and Foreign Revenue is less than $400,000,000, but greater than $300,000,000, the Borrower may use the foreign currency exchange rates for the relevant currencies that were in effect on the Closing Date to the extent such exchange rates are obtained from the same source as the rates used in producing the most recent financial statements delivered under clauses (a) and (b) of Section 6.01).”
2.2.      Section 2.04 of the Credit Agreement is amended so that the amortization grid set forth therein is amended and restated in its entirety to read as follows:
	
		
	Date
	Amount

	Closing Date to September 30, 2016
	$0.00

	October 1, 2016
	$75,000,000

	January 1, 2017
	$75,000,000

	April 1, 2017
	$75,000,000

	Maturity Date
	$75,000,000

2.3.      Section 2.11(a) of the Credit Agreement is amended and restated in its entirety to read as follows:  
“On and after the period ending six months following the Closing Date, the Borrower may by written notice to the Administrative Agent elect to request that Macquarie CAF LLC establish one or more new term loan commitments (each, an “Incremental Commitment”), in a minimum amount of at least $50,000,000, but which Incremental Commitments shall not exceed $200,000,000 in the aggregate.  Each such notice shall specify the date (the “Increase Effective Date”) on which the Borrower proposes that the Incremental Commitment shall be effective, which shall be a date not less than 10 Business Days after the date on which such notice is delivered to the Administrative Agent.  Notwithstanding anything contained herein to the contrary, the establishment of the Incremental Commitment shall be made in the sole discretion of the Administrative Agent.”
2.4.      Section 6.02(a)(ii) of the Credit Agreement is amended and restated in its entirety to read as follows:
“(ii) revenue from sales of the Kalydeco Product derived from customers located outside of the United States over the trailing twelve month period ending on such date of determination, which revenue, if consisting of currency other than US Dollars, will be calculated using the foreign exchange rates prevailing as of the date of determination (or, in the event Kalydeco Product US and Foreign Revenue is less than $400,000,000, but greater than $300,000,000, the Borrower may use the foreign 

EAST\110676466.2    

currency exchange rates for the relevant currencies that were in effect on the Closing Date to the extent such exchange rates are obtained from the same source as the rates used in producing the most recent financial statements delivered under clauses (a) and (b) of Section 6.01),”
2.5.     Section 7.02(c) of the Credit Agreement is amended and restated in its entirety to read as follows:
(c)    Investments by the Borrower and its Subsidiaries in their respective Subsidiaries outstanding on the date hereof, (ii) additional Investments by the Borrower and its Subsidiaries in Loan Parties (other than Holdings), (iii) additional Investments by Subsidiaries of the Borrower that are not Loan Parties in other Subsidiaries that are not Loan Parties and (iv) so long as no Event of Default has occurred and is continuing or would result from such Investment, additional Investments by the Loan Parties in Subsidiaries that are not Loan Parties, but only with respect to this clause (iv) to the extent that the Borrower and its Subsidiaries maintain in the aggregate at least $450,000,000 in cash and/or Cash Equivalents (the “Non-Loan Party Investment Required Cash”) (which value will be determined on a daily basis) immediately after giving effect to each such Investment (provided that (x) Non-Loan Party Investment Required Cash as used in this Section shall be increased by the amount of any advance of Incremental Loans and shall be reduced by any payments made under Section 2.03(a) or Section 2.04 and (y) Cystic Fibrosis Drug Franchise Assets may not be invested in non-Loan Party Subsidiaries under this Section 7.02(c));
2.6.     Section 7.03(e) of the Credit Agreement is amended and restated in its entirety to read as follows:
(e)    Indebtedness in respect of capital leases (other than capitalized real estate leases), Synthetic Lease Obligations and purchase money obligations for fixed or capital assets within the limitations set forth in Section 7.01(i); provided, however, that the aggregate amount of all such Indebtedness shall not exceed at any time outstanding $35,000,000 for the 2015 calendar year, $65,000,000 for the 2016 calendar year and $95,000,000 for the 2017 calendar year (for the avoidance of doubt, any of such Indebtedness which is listed on Schedule 7.03 shall not count toward the calculation of such baskets) .
2.7.      Section 7.06 of the Credit Agreement is hereby amended to remove the period at the end of Section 7.06(f), to insert “; and” at end of Section 7.06(f),  and add the following section (g) immediately after Section 7.06(f):
“(g)    the Borrower may, either directly or indirectly, repurchase shares of its stock from its stockholders (“Share Buyback”), but only to the extent that the Borrower and its Subsidiaries maintain in the aggregate at least $450,000,000 in cash and/or Cash Equivalents (the “Share Buyback Required Cash”) (which value will be determined on a daily basis) immediately after giving effect to the Share Buyback payment; provided that Share Buyback Required Cash as used in this Section shall be increased by the amount of any advance of Incremental Loans and shall be reduced by any payments made under Section 2.03(a) or Section 2.04.

EAST\110676466.2    

2.8.    Schedules 1.01, 5.05, 5.08 and 5.13 are hereby amended in their entirety to read as set forth on Exhibit A hereto.
SECTION 3.    Effectiveness.  This Amendment shall become effective as of the date first written above when  (i) the Administrative Agent (or its counsel) shall have received duly executed and completed counterparts hereof (in the form provided and specified by the Administrative Agent) that, when taken together, bear the signatures of each Loan Party, the Administrative Agent and each of the Lenders; and (ii) the representations and warranties set forth in Section 4 of this Amendment are true and correct in all material respects.
SECTION 4.      Representations and Warranties.  To induce the other parties hereto to enter into this Amendment, each Loan Party represents and warrants to each of the Lenders and the Administrative Agent that:
4.1.         Each of the representations and warranties made by any of the Loan Parties in the Loan Documents (other than the representation and warranty set forth in Section 5.18(a) of the Credit Agreement and other than representations and warranties contained in the Collateral Documents that refer to schedules to such Collateral Documents) is true and correct in all material respects (except any such representation and warranty which is qualified by materiality, which is correct and accurate in all respects) on and as of the Amendment Effective Date as if made on such date; provided if any such representation and warranty is expressly made only as of a prior date, such representation and warranty is true as of such prior date.  No Default or Event of Default exists or is continuing under any of the Loan Documents.
4.2.     The execution, delivery and performance by each Loan Party of this Amendment, and the consummation of the transactions contemplated hereby, are within their respective corporate, limited liability company or other powers, have been duly authorized by all necessary respective corporate, limited liability company or other organizational action, and do not and will not (i) violate the certificate of formation, certificate of incorporation or other constitutive documents or operating agreement, bylaws or other organizational document of any Loan Party, or (ii) violate any law, statute, rule or regulation applicable to such party in any material respect; and
4.3.      This Amendment has been duly executed and delivered by each of the Loan Parties party hereto, and constitutes a legal, valid and binding obligation of each such Loan Party, enforceable against it in accordance with its terms, subject to (i) the effects of bankruptcy, insolvency, moratorium, reorganization, fraudulent conveyance or other similar laws affecting creditors’ rights generally, (ii) general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law) and (iii) implied covenants of good faith and fair dealing.
SECTION 5.    Effect of Amendment.  
5.1.      Except as expressly set forth herein, this Amendment shall not by implication or otherwise limit, impair, constitute a waiver of or otherwise affect the rights and remedies of the Lenders or the Administrative Agent under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in any way affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other provision of the Credit Agreement or of any other Loan Document, all of which are ratified and affirmed in all respects and 

EAST\110676466.2    

shall continue in full force and effect.  Nothing herein shall be deemed to entitle the Borrower to a consent to, or a waiver, amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document in similar or different circumstances.
5.2.      Each Loan Party agrees that (a) all of its obligations, liabilities and indebtedness under any Loan Document to which it is a party, including, if applicable, its guarantee of the Obligations, shall remain in full force and effect on a continuous basis after giving effect to this Amendment and (b) all of the Liens and security interests created and arising under such Loan Documents shall remain in full force and effect on a continuous basis, and the perfected status and priority of each such Lien and security interest shall continue in full force and effect on a continuous basis, unimpaired, uninterrupted and undischarged, after giving effect to this Amendment as collateral security for its Obligations under the Credit Agreement and for its guarantees in the other Loan Documents.
5.3.      On and after the Amendment Effective Date, each reference in the Credit Agreement to “this Agreement”, “hereunder”, “hereof”, “herein”, or words of like import, and each reference to the Credit Agreement in any other Loan Document shall be deemed a reference to the Credit Agreement as amended hereby.  This Amendment shall constitute a “Loan Document” for all purposes of the Credit Agreement and the other Loan Documents.
SECTION 6.    General.
6.1.      GOVERNING LAW.  THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.
6.2.      Costs and Expenses.  The Borrower agrees to reimburse the Administrative Agent for its reasonable out-of-pocket costs and expenses incurred in connection with the preparation, negotiation and execution of this Amendment, including, without limitation, the reasonable out-of-pocket fees, charges and disbursements of counsel to the Administrative Agent.
6.3.      Counterparts.  This Amendment may be executed in counterparts (and by different parties hereto on different counterparts), each of which shall constitute an original, but all of which when taken together shall constitute a single contract.  Delivery of any executed counterpart of a signature page of this Amendment by telecopy or email transmission (including by “.pdf” or “.tif” electronic format) shall be effective as delivery of a manually executed counterpart of this Amendment.
6.4.      Headings.  The headings of this Amendment are used for convenience of reference only, are not part of this Amendment and shall not affect the construction of, or be taken into consideration in interpreting, this Amendment. 
[remainder of page intentionally left blank]

EAST\110676466.2    

EXECUTION COPY

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and delivered by their duly authorized officers as of the date first above written.
VERTEX PHARMACEUTICALS INCORPORATED, as Borrower

By: /s/ Ian Smith                                                
Name: Ian Smith
Title: Chief Financial Officer
 
VERTEX PHARMACEUTICALS (SAN DIEGO) LLC, as a Guarantor 
By: /s/ Ian Smith                                                
Name: Ian Smith 
Title: Treasurer 
VERTEX PHARMACEUTICALS (DELAWARE) LLC, as a Guarantor
By: /s/ Ian Smith                                                
Name: Ian Smith 
Title: Treasurer
VERTEX PHARMACEUTICALS (DISTRIBUTION) INCORPORATED, as a Guarantor
By: /s/ Ian Smith                                                
Name: Ian Smith 
Title: Treasurer
VERTEX PHARMACEUTICALS (PUERTO RICO) LLC, as a Guarantor
By: /s/ Ian Smith                                                
Name: Ian Smith 
Title: Treasurer
VERTEX HOLDINGS, INC., as a Guarantor
By: /s/ Ian Smith                                                
Name: Ian Smith     
Title: Treasurer

EAST\110676466.2 

	
		
	MACQUARIE US TRADING LLC,  as Administrative Agent

	 
	 

	/s/ Joshua Karlin

	By:
	Joshua Karlin

	Title:
	Authorized Signatory

	 
	 

	/s/ Anita Chiu

	By:
	Anita Chiu

	Title:
	Associate Director

	 
	 

	MACQUARIE CAF LLC

	 
	 

	/s/ D. Price/ G. Scarpa

	By:
	D. Price/ G. Scarpa

	Title:
	Authorized Signatories

	 
	 

	APPOLLO CREDIT FUNDING I LTD

	 
	 

	By:
	Apollo ST Fund Management LLC, its collateral manager

	 
	 

	/s/ Joseph Moroney

	By:
	Joseph Moroney

	Title:
	Authorized Signatory

	 
	 

	 
	 

EAST\110676466.2    

	
		
	APPOLLO LINCOLN FIXED INCOME FUND, L.P.

	 
	 

	By:
	Apollo Lincoln Fixed Income Management LLC, its collateral manager

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

	 
	 

	APPOLLO TR OPPRTUNISTIC, LTD.

	 
	 

	By:
	Apollo Total Return Master Fund, L.P., its member

	 
	 

	By:
	Appollo Total Return Advisors, L.P., its General Partner

	 
	 

	By:
	Apollo Total Return Advisors GP, LLC, its General Partner

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

	 
	 

	MIDCAP FUNDING V TRUST (formerly known as MidCap Funding V, LLC

	 
	 

	By:
	Apollo Capital Management, L.P., its investment manager

	 
	 

	By:
	Apollo Capital Management, GP, LLC, its general partner

	 
	 

	/s/ Howard Widra

	By:
	Howard Widra

	Title:
	Authorized Signatory

EAST\110676466.2    

	
		
	HIGHBRIDGE AIGUILLES ROUGES SECTOR B INVESTMENT FUND, L.P.

	 
	 

	By:
	Highbridge Principal Strategies, LLC

	 
	 

	/s/ Vikas Keswani

	By:
	Vikas Keswani

	Title:
	Managing Director

	 
	 

	APOLLO ALTERNATIVE CREDIT ABSOLUTE RETURN FUND L.P.

	 
	 

	By:
	Apollo Alternative Credit Absolute Return Management LLC, its Investment Manager

	 
	 

	/s/ Joseph Glatt

	By:
	Joseph Glatt

	Title:
	Vice President

EAST\110676466.2

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