Document:

<PAGE>   1
                                                                    EXHIBIT 10.8

                  THIS SUBLICENSE, made this 15th day of February, 1994, by and
between INTEGRAL CONCEPTS, INC., a West Virginia Corporation ("ICI"), having a
place of business at Route 7, Box 145 Morgantown, West Virginia 26505, and
INTEGRAL VISION SYSTEMS, INC., a West Virginia Corporation ("IVS"), having a
place of business at the same address.

                                   WITNESSETH

                  WHEREAS, ICI is a corporation formed to commercialize various
proprietary technologies developed by itself and others, including the West
Virginia University Research Corporation ("WVURC");

                  WHEREAS, by an agreement dated January 19, 1993 (the
"Agreement", Exhibit 1, made a part hereof), WVURC granted ICI an exclusive
worldwide license, inter alia, to manufacture the Technology and to sublicense
other to manufacture the Technology;

                  WHEREAS, pursuant to the Agreement, WVURC and ICI anticipated
that further development work could be required to complete the Technology,
which ICI would do at its own expense;

                  WHEREAS, IVS is a corporation formed by certain principals of
ICI for the purpose of marketing the Technology;

                  WHEREAS, ICI desires to issue an exclusive sublicense to IVS
of its right, title, and interest in and to the Technology as fully as legally
possible subject only to those

<PAGE>   2
                                      - 2 -

limitations and restrictions on ICI's rights contained in the Agreement;

                  NOW THEREFORE, for the consideration and the mutual exchange
of promises set forth herein, the parties hereby agree as follows,

                            I. SUBLICENSE AND LICENSE

                  1.1 ICI hereby grants to IVS the exclusive worldwide right and
license to (i) manufacture the Technology and to license others to do so, (ii)
to market, sell copies of, license and distribute the Technology, and (iii) to
sublicense others to manufacture, market, sell copies of, license and distribute
the Technology.

                  1.2 IVS agrees to accept those limitations and restrictions on
its rights under this Sublicense Agreement that result from rights reserved to
WVURC under the Agreement.

                  1.3 IVS agrees to make a one time fixed payment to ICI of
$10,000 as soon as possible after the execution of this Sublicense Agreement as
further compensation for the transfer of the Technology.

                              II. CONFORMING TERMS

                  2.1 To the extent not otherwise defined herein, the terms used
in this Sublicensing Agreement shall have the meaning set forth or implied in
the Agreement.

                  2.2 IVS agrees to pay directly to WVURC the royalty

<PAGE>   3
                                     - 3 -

stipulated in the Agreement. In the event that WVURC does not agree to direct
royalty payment, IVS agress to reimburse ICI for any expenses that it incures
pursuant to the "Payments" section of the Agreement, including any income taxes
attracted by the conduit payment arrangement. In other words, IVS agrees to hold
ICI harmless for any intermediary role it may have to play pursuant to the
Agreement.

                  2.3 IVS agrees to undertake the equivalent steps agreed to by
ICI in the Agreement to promote and market the Technology.

                  2.4 IVS will undertake equivalent confidentiality rules as ICI
in the Agreement.

                  2.5 IVS agrees to equivalent protection rules regarding
Proprietary Rights as set forth in the Agreement.

                  2.6 IVS and ICI agree that this Sublicense Agreement will have
equivalent provisions regarding Term, Termination, and Conversion as set forth
in the Agreement.

                  2.7 IVS and ICI agree to equivalent Miscellaneous conditions
as set forth in the Agreement, with the specification that notices to IVS will
be to the address for it indicated above.

                  2.8 In exchange for the transfer of Technology contemplated
herein, IVS agrees to hold ICI harmless against any consequences, financial and
otherwise, that may arise from the transactions contemplated herein. This hold
harmless agreement

<PAGE>   4
                                     - 4 -

is intended to be broad enough to encompass any adverse consequences that may
flow from this agreement and be supported directly or indirectly by ICI. By way
of illustration (and in no way limiting the intended scope of this hold harmless
clause), should ICI by joined as a party in any suit because of actions
undertaken by IVS regarding the Technology, IVS agrees to pay, among other
things, for ICI's cost of defending the suit (payment to be in a prompt manner),
and the costs of any damage ultimately supported by ICI.

                  2.9 The parties agree that any controversy or claim arising
out of or relating to this Sublicense Agreement, or the breach thereof, shall be
settled by arbitration in accordance with the Commercial Arbitration Rules of
the American Arbitration Association, and judgment upon the award rendered by
the arbitrator(s) may be entered in any court having jurisdiction thereof. This
contract shall be interpreted under the laws of the State of West Virginia.

                  2.10 IVS and ICI agree to execute such other documents as may
be required to put into effect the overall purpose of this Sublicense Agreement,
it being the intention of the parties that IVS essentially step into ICI's shoes
regarding all obligations under the Agreement as if it had been originally
between WVURC and IVS. This will include but not be limited to, an explicit
license by ICI and IVS of any patents or patentable rights subsequently
developed for the Technology by ICI.

<PAGE>   5
                                     - 5 -

         IN WITNESS WHEREOF, the parties have executed this Sublicense Agreement
as of the date first indicated above.

/s/ Rhonda L. Miller                        Integral Concepts, Inc.
--------------------                        By: /s/ James Smith
Witness                                         ---------------
                                            Its: President
                                                 --------------

                                            Integral Vision Systems, Inc.
/s/ Rhonda L. Miller                        By: /s/ James Smith
--------------------                            ---------------
Witness                                     Its: President
                                                 --------------

<PAGE>   6

EXHIBIT 1 to sublicense between ICI and IVS

                                    AGREEMENT

This Agreement is made this 19th day of January, 1993, by and between West
Virginia University Research Corporation, a nonprofit corporation of the State
of West Virginia, having an office at the Office of Sponsored Programs, P.O. Box
6845, Morgantown, West Virginia 26506-6845 (hereinafter referred to as "WVURC")
and Integral Concepts, Inc., a West Virginia corporation (hereinafter referred
to as "ICI") having a place of business at Route 7, Box 145, Morgantown, West
Virginia 26505.

                                   WITNESSETH

         WHEREAS, James E. Smith and others working under his guidance and
direction have developed certain vision system technologies and defined herein
to be embraced within the expression "The Technology";

         WHEREAS, The Technology was not specifically commissioned by WVURC and
grew out of intellectual pursuits of Smith and others; and

         WHEREAS, The Technology was developed, in part, as a result of the
position of Smith and others at WVU; and, in part, as a result of the use by
Smith and others at WVU and/or WVURC resources; and, in part, by Smith and
others without the use of WVURC resources; and

         WHEREAS, the parties agree that Smith, and others, and WVURC jointly
own all right, title and interest in The Technology, as defined by the current
WVURC Patent and Copyright Policy, a copy of which is labeled as Exhibit 1,
attached hereto, and incorporated herein by reference; and

         WHEREAS, ICI wishes to obtain an exclusive license from WVURC of its
right, title and interest on and to The Technology, subject to there terms and
conditions hereof;

         NOW, THEREFORE, in consideration of the payment of monies as
hereinafter

                                       1
<PAGE>   7
EXHIBIT 1 to sublicense between ICI and IVS

required, and of the mutual exchange of promises recited herein, the parities
hereto intending to be legally bound hereby agree as follows:

                                 I. DEFINITIONS

         1.1 As used in this Agreement, the following terms shall have the
following meanings:

         (a) "The Technology shall mean that process and equipment set forth and
identified in Exhibit 2 and its attachments and amendments, if any, all of which
are, or if attachment or amendments shall be, attached hereto and made apart
hereof. Except as reflected herein or in any written modifications hereto, The
Technology does not include modifications or enhancements to such process or
equipment developed or performed independently by ICI, its agents, servants,
employees, contractors, assigns or successors, which are subject to patent or
copyright protection in their own right, whether so protected or not.

         (b) "Net Revenues" means any and all money or other consideration,
received by ICI from the sale, leasing or sublicensing of The Technology
pursuant to which third parties are permitted to use or market The Technology;
less customer discounts and returns; less sales commissions and royalty payments
(other than royalty payments due under Article III hereof); and less actual
operational expenses incurred.

                                   II. LICENSE

         2.1 WVURC hereby grants to ICI the exclusive worldwide right and
license (i) to manufacture The Technology and to license others to do so; and
(ii) to sublicense others to manufacture, market, sell copies of, license and
distribute The Technology.

         2.2 WVURC reserves the nonterminable, royalty-free right to use and
copy The Technology for research, development and noncommercial WVURC purposes.

                                       2
<PAGE>   8
EXHIBIT 1 to sublicense between ICI and IVS

                                  III. PAYMENTS

         3.1 ICI shall pay to WVURC as a nonrefundable, noncreditable initial
license fee the sum of One Dollar ($1.00) and other good and valuable
consideration, due upon the execution of this agreement.

         3.2 ICI shall pay to WVURC as a minimum annual royalty on December 31,
1993, and each December 31 thereafter, during the term of this Agreement, or any
renewals thereof, the sum of Three Thousand Dollars ($3,000). In any year which
the earned royalties exceed the minimum royalty, no additional payment of the
minimum royalty shall be required.

         3.3 ICI shall pay to WVURC as an earned royalty on sales, leases or
sublicenses by ICI as to "The Technology" a sum equal to 10% of the "Net
Revenues" as above defined.

                                  IV. MARKETING

         4.1 It is understood by the parties that further work may be required
to complete "The Technology" and that ICI will, at its own expense, seek to
effect such completion using such efforts and resources as it, in its sole
discretion, determines appropriate under the then existing circumstances. The
parties agree that WVURC shall participate as an owner in any subsequent
developmental work to the extent defined by Exhibit 2 attached hereto.

         4.2 ICI agrees that it will use such efforts and resources to
distribute The Technology through sales, leases, or sublicenses, as ICI shall,
in its sole discretion, determine to be appropriate under the then existing
circumstances.

         4.3 ICI shall have the right to prepare, copy, edit, publish, sell,
distribute and license The Technology throughout the world in any variety of
forms or applications. ICI shall annually provide WVURC with a written
comprehensive report providing details of the status of the work under this
Agreement including but not limited to documentation, support, packaging,
advertising, and promotion concepts and designs related to The Technology and as
to sublicenses.

                                       3
<PAGE>   9
EXHIBIT 1 to sublicense between ICI and IVS

                               V. CONFIDENTIALITY

         5.1 The trade secrets and technology embodied in The Technology, or the
existing or future products of hardware manufacturers, any methods or protection
employed by to prevent unauthorized duplication of software programs, the terms
of this Agreement, and any other confidential business or technical information
disclosed by WVURC to ICI or by ICI to WVURC shall beheld in strict confidence
and shall not be disseminated by WVURC or ICI, except by ICI to a buyer, lessee
or sublicensor, when such between ICI and customer, imposing obligations on
customer no less than those imposed by this Section V on ICI.

         5.2 The obligation of this Section V shall survive the expiration or
termination of this Agreement.

                              VI. PAYMENTS, REPORTS

         6.1 Earned royalties due WVURC hereunder shall be calculated on a
calendar quarterly basis, and shall be paid within forty-five (45) days after
the close of each calendar quarter to such address as WVURC may direct in
writing.

         6.2 At the time of payment ICI shall deliver to WVURC a report which
shall provide all reasonably necessary information for computation of the
payments, if any, due or credited to WVURC for such period, together with any
adjustments in payments due WVURC with respect to such period.

                             VII. PROPRIETARY RIGHTS

         7.1 WVURC and ICI acknowledge that The Technology is of a character
which is or may be protectable by patent, trade secret and/or copyright under
the laws of the Unite States and other countries. WVURC shall, at its own
expense obtain patent and/or copyright or other

                                       4
<PAGE>   10
EXHIBIT 1 to sublicense between ICI and IVS

statutory protection of "The Technology" described in Exhibit 2 of even date
with the original Agreement.

         It is explicitly recognized that there are other items of Technology
which may be developed and incorporated by amendment or attachment to Exhibit 2
of this Agreement. WVURC will not be responsible for obtaining patent and/or
copyright or other statutory protection of such Technology. ICI will be solely
responsible for obtaining patent and/or copyright or other statutory protection
of all forms of The Technology as defined in Exhibit 2 which are developed in
the future and incorporated by amendment to this Agreement. All such patents
and/or copyrights or other statutory protection shall name WVURC as the owner of
each so protected Technology.

         ICI shall treat documentation regarding The Technology including
listing of source code for The Technology, but not including instructions,
manuals or other elements of any publicly marketed material from The Technology
as proprietary, confidential information. ICI shall use reasonable efforts to
obtain and maintain proprietary protection for The Technology consistent with
ICI's ability to effectively market The Technology in each country in which The
Technology is distributed. WVURC agrees to cooperate with ICI, at ICI's expense,
and where necessary ICI agrees to obtain patent, copyright or other statutory
protection for The Technology in each country in which the same are sold,
distributed or sublicensed, and WVURC's hereby authorizes ICI to execute and
prosecute in WVURC's name as author's or inventors an application for patent,
copyright or similar protection of The Technology, and WVURC shall execute such
other documents of registration and recordation as may be necessary to perfect
in ICI, or protect, the exclusive rights granted ICI hereunder in each country I
which such items are sold or distributed.

                                       5
<PAGE>   11
EXHIBIT 1 to sublicense between ICI and IVS

         7.2 Any trademark used by ICI to identify The Technology shall be owned
by WVURC and ICI to the same extent, and in the same proportions as the
underlying technology.

         7.3 ICI may identify WVURC as an owner or participant in The Technology
and its development provided that such use of the WVURC identification is an
accurate statement of WVURC's role, and notice thereof has been given to WVURC
at the address indicated herein not less than 10 days prior to the first such
identification.

                     VIII. TERM, TERMINATION, AND CONVERSION

         8.1 The term of this Agreement shall commence on the date first set
forth above and shall continue until December 31, 1996, unless earlier
terminated as provided in this Agreement.

         8.2 This Agreement shall be automatically renewed for one year periods
after December 31, 1996 so long as payments to WVURC exceed the minimum royalty
payment specified in Article 3.2 or earned royalties paid exceed the minimum
royalties during any two of three consecutive quarters of the preceding year.

         8.3 In the event of the bankruptcy of either party, or a material
breach of a material provision hereof, which breach is not cured within sixty
(60) days after written notice thereof by the non-breaching party, then said
party may, effective thirty (30) days after written notice thereof to the other,
terminate this Agreement, and rights granted hereunder shall thereupon revert to
the appropriate party as provided in Section 8.4 hereof. In addition to, or in
lieu of their rights to terminate this Agreement upon material breach, the
non-breaching party shall have the right to pursue any remedies available to
them under law.

         8.4 Upon any termination of this Agreement: (1) all rights, title and
interest of ICI in and to The Technology, as conveyed hereby, including, but not
limited to, design drawings and production material relating thereto in ICI's
possession will terminate and revert to WVURC; (2)

                                       6
<PAGE>   12
EXHIBIT 1 to sublicense between ICI and IVS

all rights and licenses granted by ICI to third parties shall continue to full
force and effect, monies due thereunder shall be received by ICI and royalties
paid to WVURC as provided herein; (3) WVURC shall in any event have the right to
retain copies of any version of The Technology for WVURC's own use; and (4)
ICI's obligation to pay WVURC earned royalties then due shall continue. Nothing
herein shall be deemed to affect or require ICI to convey to WVURC any right,
title and/or interest in and to enhancements to The Technology, or additions
thereto, made or developed as a result of ICI's efforts concerning The
Technology occurring after the date hereof. That is, the parties recognize and
agree that ICI will acquire additional rights and ownership interests in and to
The Technology as a result of developmental efforts pertaining thereto except as
described in Exhibit 2.

                                IX. MISCELLANEOUS

         9.1 Each party will notify the other of any infringements of rights in
The Technology that come to such party's attention and shall cooperate fully
with the other in determining what action, if any, should be taken.

         9.2 This Agreement states the entire agreement between the parties with
respect to the subject matter hereof and supersedes all prior negotiations,
understandings and agreements between the parties hereto concerning the subject
matter hereof. No amendment or modification of this Agreement shall be made
except by an instrument in writing signed by all parties.

         9.3 WVURC represents: (i) this Agreement has been duly executed and
delivered and is a valid and binding agreement; and (ii) the execution and
delivery of this Agreement, and the performance by WVURC of its obligations
hereunder, are not in violation of and will not conflict with any agreement,
law, order or other restriction binding on WVURC.

         9.4 The parties' rights and obligations hereunder shall be binding upon
and inure to the

                                       7
<PAGE>   13
EXHIBIT 1 to sublicense between ICI and IVS

benefit of their respective successors and assigns. Each party hereto will
notify the other party in writing of any transfer of its rights or obligations
hereunder within sixty (60) days of such transfer, provided, however, that ICI
or its assignee will not be required to give notice of any such transfer made
pursuant to a license agreement or other transaction in the ordinary course of
its business.

         9.5 This Agreement shall be governed by and interpreted in accordance
with the laws of the State of West Virginia.

         9.6 Should any provision of this Agreement be held to be void, invalid
or inoperative, the remaining provisions of this Agreement shall not be affected
and shall continue in effect as though such provisions were deleted.

         9.7 WVURC agrees that all payments to others, as required by WVURC's
"Patent and Trademark Policy" shall be the sole responsibility of WVURC, and
such payments shall be made from WVURC's royalties received under this
Agreement.

         9.8 Any notice required or permitted to be sent hereunder shall be
deemed given (a) if hand delivered when received, or (b) if mailed when mailed
by postage prepaid, by registered or certified mail, return receipt requested,
to any party at the following addresses, or such other addressees which either
party may from time to time identify:

         WVURC                                            ICI

         William W. Reeves                           James E. Smith
         Secretary                                   President
         213 Glennlock Hall                          Route 7, Box 145
         P.O. Box 6845                               Morgantown, WV  26505
         Morgantown, WV  26506-6845

                                       8
<PAGE>   14
EXHIBIT 1 to sublicense between ICI and IVS

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

                                           WEST VIRGINIA UNIVERSITY RESEARCH
                                           CORPORATION
                                           On behalf of
                                           WEST VIRGINIA RESEARCH CORPORATION

/s/ Lory B. Dalton                         By: /s/ William W. Reeves
----------------------                        ----------------------------------
Witness                                            William W. Reeves
                                           Title:  Secretary

                                           INTEGRAL CONCEPTS, INC.

                                           By: /s/ James E. Smith
                                              ----------------------------------
                                                   James E. Smith
                                           Title: President
/s/ Rolf Wohl
----------------------
Witness

                                       9<PAGE>

                                                                     Exhibit 4.2

THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE BEEN ACQUIRED FOR INVESTMENT
AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED OR
STATE SECURITIES LAWS.  THESE SECURITIES MAY NOT BE SOLD OR TRANSFERRED IN THE
ABSENCE OF SUCH REGISTRATION OR AN EXEMPTION THEREFROM UNDER SAID ACT OR STATE
SECURITIES LAWS.

No. W-3                  Right to Purchase 30,538 Shares of Series A
                         Preferred Stock of OraPharma, Inc.

                                ORAPHARMA, INC.

                   Series A Preferred Stock Purchase Warrant

     This is to certify that, FOR VALUE RECEIVED, OAK INVESTMENT PARTNERS VI,
LIMITED PARTNERSHIP (the "Holder"), is entitled to purchase, subject to the
provisions of this Warrant, from OraPharma, Inc., a Delaware corporation (the
"Company"), 30,538 fully paid, validly issued and nonassessable shares of Series
A Preferred Stock, par value $.001 per share, of the Company (the "Preferred
Stock") at an exercise price of $1.00 per share.  The number of shares of
Preferred Stock to be received upon the exercise of this Warrant and the price
to be paid for each share of Preferred Stock may be adjusted from time to time
as hereinafter set forth.  The shares of Preferred Stock deliverable upon such
exercise, and as adjusted from time to time, are hereinafter sometimes referred
to as "Warrant Shares" and the exercise price of a share of Preferred Stock in
effect at any time and as adjusted from time to time is hereinafter sometimes
referred to as the "Exercise Price."

                   1.  EXERCISE OF WARRANT

                         a.  Exercise for Cash.  This Warrant may be exercised
in whole or in part at any time or from time to time until 5:00 p.m. Eastern
Standard Time on December 3, 2003 (the "Exercise Period"). This Warrant may be
exercised by presentation and surrender hereof to the Company at its principal
office, or at the office of its stock transfer agent, if any, with the Purchase
Form annexed hereto duly executed and accompanied by payment of the Exercise
Price for the number of Warrant Shares specified in such form. The Exercise
Price may be paid by bank check, wire transfer or cancellation of indebtedness.
As soon as practicable after each such exercise of this Warrant, but not later
than seven (7) days from the date of such exercise, the Company shall issue and
deliver to the Holder a certificate for the Warrant Shares issuable upon such
exercise, registered in the name of the Holder. If this Warrant should be
exercised in part only, the Company shall, upon surrender of this Warrant for
cancellation, execute and deliver a new Warrant evidencing the rights of the
Holder thereof to purchase the balance of the Warrant Shares purchasable
thereunder. Upon receipt by the Company of this Warrant at its office, or by the
stock transfer agent of the Company at its office, in
<PAGE>

proper form for exercise, the Holder shall be deemed to be the holder of record
of the shares of Preferred Stock issuable upon such exercise, notwithstanding
that the stock transfer books of the Company shall then be closed or that
certificates representing such shares of Preferred Stock shall not then be
physically delivered to the Holder.

                   b.  Warrant Exchange.  At any time during the Exercise
Period, the Holder may, at its option, exchange this Warrant, in whole or in
part (a "Warrant Exchange"), into the number of Warrant Shares determined in
accordance with this Section 1(b), by surrendering this Warrant at the principal
office of the Company or at the office of its stock transfer agent, accompanied
by a notice stating the Holder's intent to effect such exchange, the number of
Warrant Shares to be exchanged and the date on which the Holder requests that
such Warrant Exchange occur (the "Notice of Exchange"). The Warrant Exchange
shall take place on the date specified in the Notice of Exchange or, if later,
the date the Notice of Exchange is received by the Company (the "Exchange
Date"). Certificates for the shares issuable upon such Warrant Exchange and, if
applicable, a new warrant of like tenor evidencing the balance of the shares
remaining subject to this Warrant, shall be issued as of the Exchange Date and
delivered to the Holder within seven (7) days following the Exchange Date. In
connection with any Warrant Exchange, this Warrant shall represent the right to
subscribe for and acquire the number of Warrant Shares equal to (i) the number
of Warrant Shares specified by the Holder in its Notice of Exchange (the "Total
Number") less (ii) the number of Warrant Shares equal to the quotient obtained
by dividing (A) the product of the Total Number and the existing Exercise Price
by (B) the Fair Market Value. "Fair Market Value" shall be determined as
follows: (1) if the Preferred Stock is listed on a national securities exchange
or admitted to unlisted trading privileges on such exchange or listed for
trading on the Nasdaq Stock Market, the Fair Market Value shall be the average
of the last reported sale prices of the Preferred Stock on such exchange or
system for the twenty (20) business days ending on the last business day prior
to the date for which the determination is being made; or (2) if the Preferred
Stock is not so listed or admitted to unlisted trading privileges, the Fair
Market Value shall be the average of the last reported bid and asked prices
reported by the National Quotation Bureau, Inc. for the twenty (20) business
days ending on the last business day prior to the date for which the
determination is being made; or (3) if the Preferred Stock is not so listed or
admitted to unlisted trading privileges and bid and asked prices are not so
reported, the Fair Market Value shall be an amount, not less than book value
thereof as at the end of the most recent fiscal quarter of the Company ending
prior to the Exchange Date, determined in such reasonable manner as may be
prescribed by the Board of Directors of the Company.

                   2.  RESERVATION OF SHARES.  The Company shall at all times
reserve for issuance and/or delivery upon exercise of this Warrant such number
of shares of its Preferred Stock as shall be required for issuance and delivery
upon exercise of this Warrant.

                   3.  FRACTIONAL SHARES.  No fractional shares of Preferred
Stock shall be issued upon the exercise of this Warrant. With respect to any
fraction of a share called for upon any exercise hereof, the Company shall pay
to the Holder an amount in

                                       2
<PAGE>

cash equal to such fraction multiplied by the Fair Market Value of a
share of Preferred Stock.

                   4.  ANTIDILUTION PROVISIONS.

                         a.  Adjustments for Stock Splits, etc.  In the event
the Preferred Stock is changed by reason of a stock split, reverse stock split,
stock dividend or recapitalization or is converted into or exchanged for other
securities as a result of a merger, consolidation or reorganization in which the
Company is the surviving corporation, appropriate adjustments shall be made in
the terms of this Warrant, or additional warrants shall be granted to the Holder
as shall be equitable and appropriate, or an adjustment in the number and class
of shares allocated to, and the Exercise Price of, this Warrant shall likewise
be made.

                         b.  Adjustments for Certain Issuances or Sales at Less
than the Exercise Price in Effect.

                                i.   General.  If the Company shall, at any time
from time to time, issue any shares of Preferred Stock without consideration or
for a Net Consideration Per Share less than the Exercise Price in effect
immediately prior to such issuance, then, and in each such case, the Exercise
Price in effect thereafter shall be reduced, concurrently with such issue, to a
price equal to the Net Consideration Per Share received by the Company for each
such share of Preferred Stock.

                                ii.  Other Dilutive Issuances of Options,
Warrants or Convertible Securities.

                                     (A)  The issuance of any warrants, options
or other subscription or purchase rights with respect to shares of Preferred
Stock and the issuance of any securities convertible into or exchangeable for
shares of Preferred Stock (or the issuance of any warrants, options or any
rights with respect to such convertible or exchangeable securities) shall be
deemed an issuance at such time of such Preferred Stock if the Net Consideration
Per Share which may be received by the Company for such Preferred Stock (as
hereinafter determined) shall be less than the Exercise Price at the time of
such issuance and, except as hereinafter provided, an adjustment in the Exercise
Price and the number of shares of Preferred Stock issuable upon exercise of this
Warrant shall be made upon each such issuance in the manner provided in Section
4(b)(i) above. Any obligation, agreement or undertaking to issue warrants,
options, or other subscription or purchase rights at any time in the future
shall be deemed to be an issuance at the time such obligation, agreement or
undertaking vests. No adjustment of the Exercise Price and the number of shares
of Preferred Stock issuable upon exercise of this Warrant shall be made upon the
issuance of any shares of Preferred Stock which are issued pursuant to the
exercise of any warrants, options or other subscription or purchase rights in
any convertible securities if any adjustment shall previously have been made
upon the issuance of any such warrants, options or other rights or upon the
issuance of

                                       3
<PAGE>

any convertible securities (or upon the issuance of any warrants, options or any
rights therefor) as above provided.

                                     (B)  Expiration or Cancellation of
Options, Warrants or Convertible Securities. Any adjustment of the Exercise
Price and the number of shares of Preferred Stock issuable upon exercise of this
Warrant with respect to this Section 4(b)(ii) which relates to warrants, options
or other subscription or purchase rights with respect to shares of Preferred
Stock shall be disregarded if, as, and when all of such warrants, options or
other subscription or purchase rights expire or are cancelled without being
exercised, so that the Exercise Price effective immediately upon such
cancellation or expiration shall be equal to the Exercise Price in effect at the
time of the issuance of the expired or cancelled warrants, options or other
subscriptions or purchase rights, with such additional adjustments as would have
been made to that Exercise Price had the expired or cancelled warrants, options
or other subscriptions or purchase rights not been issued.

                                iii. Definition of Net Consideration Per Share.
For purposes of this Section 4(b), the "Net Consideration Per Share" which may
be received by the Company be determined as follows:

                                     (A)  If the consideration received by the
Company in connection with the issuance of shares of the Preferred Stock or the
issuance of any of the securities described in this Section 4 consists of cash,
such consideration shall be deemed to be the amount of such cash (provided that
in no case shall any deduction be made for any commissions, discounts or other
expenses incurred by the Company in connection therewith). If a part or all of
the consideration received by the Company in connection with the issuance of
shares of the Preferred Stock or the issuance of any of the securities described
in this Section 4, consists of property other than cash, such consideration
shall be deemed to have the same value as shall be determined in good faith by
the Board of Directors of the Company.

                                     (B)  For purposes of Section 4(b)(ii)
above, the "Net Consideration Per Share" shall mean the amount equal to the
total amount of consideration, if any, received by the Company for the issuance
of such warrants, options, subscriptions, or other purchase rights or
convertible or exchangeable securities, plus the minimum amount of
consideration, if any, payable to the Company upon exercise or conversion
thereof, divided by the aggregate number of shares of Preferred Stock that would
be issued if all such warrants, options, subscriptions, or other purchase rights
or convertible or exchangeable securities were exercised, exchanged or
converted.

                         c.  Miscellaneous.

                                i.   No adjustment in the Exercise Price shall
be required unless such adjustment would require an increase or decrease of at
least 5% in such Exercise Price; provided, however, that any adjustments which
by reason of this

                                       4
<PAGE>

Section 4(c) are not required to be made shall be carried forward and taken into
account in any subsequent adjustment required to be made hereunder.

                                ii.  Notwithstanding anything contained herein
to the contrary, Section 4(b) above shall not apply under any of the
circumstances described in Section 4(a) above or with respect to Excluded Stock
(as defined in the Company's Certificate of Designation with respect to its
Preferred Stock filed with the Secretary of State of the State of Delaware on
December 2, 1996).

                   5.  CERTAIN EXTRAORDINARY TRANSACTIONS.  In the event the
Preferred Stock is exchanged for securities, cash or other property of any other
corporation or entity as the result of a reorganization, merger or consolidation
in which the Company is not the surviving corporation, the dissolution or
liquidation of the Company, or the sale of all or substantially all the assets
of the Company, the Board of Directors of the Company or the board of directors
of any successor corporation or entity may, in its discretion, as to the
unexercised portion of this Warrant, (a) provide for payment of an amount equal
to the excess of the fair market value of the Warrant Shares, as determined by
the Board of Directors of the Company or such board, over the Exercise Price of
such Warrant Shares as of the date of the transaction, in exchange for the
surrender of the right to exercise this Warrant, or (b) provide for the
assumption of this Warrant, or the substitution therefor of new warrants, by the
successor corporation or entity.

                   6.  LOSS OF WARRANT.  Upon receipt by the Company of
evidence satisfactory to it of the loss, theft, destruction or mutilation of
this Warrant, and (in the case of loss, theft or destruction) of reasonably
satisfactory indemnification, and upon surrender and cancellation of this
Warrant, if mutilated, the Company will execute and deliver a new warrant of
like tenor and date.

                   7.  NO RIGHTS AS STOCKHOLDER.  The Holder shall not, as
holder of this Warrant, be entitled to vote, if applicable, or to receive
dividends or to be deemed the holder of Preferred Stock that may at any time be
issuable upon exercise of this Warrant for any purpose whatsoever, nor shall
anything contained herein be construed to confer upon the Holder, as such, any
of the rights of a stockholder of the Company or, if applicable, any right to
vote for the election of directors or upon any matter submitted to stockholders
at any meeting thereof, or to give or withhold consent to any corporate action
(whether upon any recapitalization, issue or reclassification of stock, change
of par value or change of stock to no par value, consolidation, merger or
conveyance or otherwise), or to receive notice of meetings, or to receive
dividends or subscription rights, until such holder shall have exercised the
Warrant and been issued the Warrant Shares in accordance with the provisions
hereof.

                   8.  NON-TRANSFERABILITY.  Neither this Warrant nor any
Warrant Shares shall be registered under the Securities Act of 1933, as amended,
and applicable state securities laws. Therefore, the Company shall require, as a
condition of allowing the transfer or exchange of this Warrant or such Warrant
Shares, that the Holder of this

                                       5
<PAGE>

Warrant or such Warrant Shares, as the case may be, furnish to the Company an
opinion of counsel reasonably acceptable to the Company to the effect that such
transfer or exchange will be exempt from the registration and prospectus
delivery requirements under the Securities Act of 1933, as amended, and
applicable state securities laws. The certificates evidencing the Warrant Shares
shall bear a legend to the effect that the Warrant Shares evidenced by such
certificate have not been registered under the Securities Act of 1933, as
amended, and applicable state securities laws and are, therefore, subject to
restrictions on transfer.

                   9.  INVESTMENT REPRESENTATIONS AND WARRANTIES.  The Holder
hereby represents and warrants to the Company that (a) it has knowledge and
experience in financial and business matters sufficient to enable it to evaluate
the merits and risks of an investment in the Company; (b) it has assets
sufficient to enable it to bear the economic risk of its investment in this
Warrant and the Warrant Shares and is an "accredited investor" as defined in
Rule 501 under the Securities Act of 1933, as amended; (c) it is acquiring this
Warrant and, upon exercise, will acquire the Warrant Shares, for its own
account, and not with a view to, or for sale in connection with, any
distribution thereof; (d) it or its representatives have received from the
Company such information with respect to the Company as it has deemed necessary
and relevant in connection with this Warrant and the Warrant Shares and it has
had the opportunity, directly or through such representatives, to ask questions
of and receive answers from persons acting on behalf of the Company necessary to
verify the information so obtained; and (e) it and its officers, directors,
employees and agents have not employed any broker or finder or incurred any
liability for any brokerage or finder's fees or commissions or similar payments
in connection with this Warrant and the Warrant Shares.

                   10. GOVERNING LAW.  This Agreement and all amendments,
modifications, alterations, or supplements hereto shall be construed under and
governed by the laws of the State of Delaware and the United States of America,
without regard to the principles of conflicts of law thereof.

                   11. MISCELLANEOUS.  Except as provided in Sections 4 and 5
hereof, this Warrant and any term hereof may be changed, waived, discharged or
terminated only by an instrument in writing signed by the party against which
enforcement of such change, waiver, discharge or termination is sought. The
headings in this Warrant are for purposes of reference only and shall not limit
or otherwise affect any of the terms hereof. The invalidity or unenforceability
of any provision hereof shall in no way affect the validity or enforceability of
any other provision.

                   12. EXPIRATION.  The right to exercise this Warrant shall
expire at 5:00 p.m. Eastern Standard Time on December 3, 2003.

                                       6
<PAGE>

  This Warrant is executed as of the date and year first written above.

               .   ORAPHARMA, INC.

                     By: /s/ Michael Kishbauch
                        ---------------------------------
                   . Michael Kishbauch, President

Witness:

_____________________________________

                                       7
<PAGE>

                              FORM OF SUBSCRIPTION
                   (To be signed only on exercise of Warrant)

TO:  OraPharma, Inc.

                   b.  The undersigned, the holder of the within Warrant,
hereby irrevocably elects to exercise this Warrant for, and to purchase
thereunder _______ shares of Series A Preferred Stock, $.001 par value per
share, of OraPharma, Inc. and herewith makes payment of $_____________ therefor,
and requests that the certificates for such shares be issued in the name of, and
delivered to the undersigned at ________________________.

Dated:
                                    ____________________________________________
                                    (Signature must conform to name of holder as
                                    specified on the face of the Warrant)

                                    ____________________________________________
                                                   (Address)
                                    ____________________________________________

                                       8

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00001-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00001-of-00352.parquet"}]]