Document:

EX-10.3

 Exhibit 10.3 

SEPARATION AGREEMENT AND GENERAL RELEASE OF ALL CLAIMS 

This Separation Agreement and General Release, dated as of October 5, 2020 (the “Agreement”), is made pursuant to that certain Amended and
Restated Executive Employment Agreement made as of July 2, 2020 ( the “Employment Agreement”) entered into by and between Stephen T. Isaacs (“Employee”) on the one hand, and Aduro Biotech, Inc. (the “Company”), on
the other. This Agreement is entered into in consideration for and as condition precedent to the Company providing separation benefits to Employee pursuant to the Employment Agreement. It is understood and agreed that the Company is not otherwise
obligated to provide such benefits under the terms of the Employment Agreement and that the Company is doing so as a direct result of Employee’s willingness to agree to the terms hereof. Collectively, Employee and the Company shall be referred
to as the “Parties.” This Agreement is contingent, and shall only be effective, upon the occurrence of the Closing at the Effective Time, as such terms are defined in that certain Agreement and Plan of Merger and Reorganization, dated as
of June 1, 2020, by and among the Company, Chinook Therapeutics U.S., Inc., and Aspire Merger Sub, Inc., a wholly-owned subsidiary of the Company, as amended by that certain Amendment No. 1 to Agreement and Plan of Merger and
Reorganization, dated as of August 17, 2020. 
 1. Employee’s employment with the Company ends effective October 5, 2020 (the
“Termination Date”). Employee’s termination constitutes a “Termination by the Company without Just Cause” under paragraph 8.d. of the Employment Agreement. A Change in Control of the Company occurred on October 5, 2020.

 2. The purpose of this Agreement is to resolve any and all disputes relating to Employee’s employment with the Company, and the termination thereof
(the “Disputes”). The Parties desire to resolve the above-referenced Disputes, and all issues raised by the Disputes, without the further expenditure of time or the expense of contested litigation. Additionally, the Parties desire to
resolve any known or unknown claims as more fully set forth below. For these reasons, they have entered into this Agreement. 
 3. Employee acknowledges and
agrees that Employee has received all wages due to Employee through the Termination Date, including but not limited to all accrued but unused vacation, bonuses, commissions, options, benefits, and monies owed by the Company to Employee. Employee
further agrees and acknowledges that Employee has been fully paid and reimbursed for any and all business expenses which Employee incurred during his/her employment with the Company. 

4. The Company expressly denies any violation of any federal, state or local statute, ordinance, rule, regulation, policy, order or other law. The Company
also expressly denies any liability to Employee. This Agreement is the compromise of disputed claims and nothing contained herein is to be construed as an admission of liability on the part of the Company hereby released, by whom liability is
expressly denied. Accordingly, while this Agreement resolves all issues referenced herein, it does not constitute an adjudication or finding on the merits of the allegations in the Disputes and it is not, and shall not be construed as, an admission
by the Company of any violation of federal, state or local statute, ordinance, rule, regulation, policy, order or other law, or of any liability alleged in the Disputes. 

  
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 5. In consideration of and in return for the promises and covenants undertaken by the Company and Employee
herein and the releases given by Employee herein, Employee shall receive the benefits provided by paragraph 8.d. of the Employment Agreement. Any tax liabilities resulting from or arising out of the benefits to Employee referred to in this
paragraph, shall be the sole and exclusive responsibility of Employee. Employee agrees to indemnify and hold the Company and the others released herein harmless from and for any tax liability (including, but not limited to, assessments, interest,
and penalties) imposed on the Company by any taxing authority on account of the Company failing to withhold for tax purposes any amount from the benefits made as consideration of this Agreement. 

6. Except for any rights created by this Agreement, in consideration of and in return for the promises and covenants undertaken herein by the Company, and for
other good and valuable consideration, receipt of which is hereby acknowledged: 
 a. Employee does hereby acknowledge full and complete satisfaction of and
does hereby release, absolve and discharge the Company, Chinook Therapeutics, Inc. and each of their respective parents, subsidiaries, divisions, related companies and business concerns, past and present, as well as each of their respective
partners, trustees, directors, officers, agents, attorneys, servants and employees, past and present, and each of them (hereinafter collectively referred to as “Releasees”) from any and all claims, demands, liens, agreements, contracts,
covenants, actions, suits, causes of action, grievances, wages, vacation payments, severance payments, obligations, commissions, overtime payments, debts, profit sharing claims, expenses, damages, judgments, orders and liabilities of whatever kind
or nature in law, equity or otherwise, whether known or unknown to Employee which Employee now owns or holds or has at anytime owned or held as against Releasees, or any of them, including specifically but not exclusively and without limiting the
generality of the foregoing, any and all claims, demands, grievances, agreements, obligations and causes of action, known or unknown, suspected or unsuspected by Employee: (1) arising out of or in any way connected with the Disputes; or
(2) arising out of Employee’s employment with the Company; or (3) arising out of or in any way connected with any claim, loss, damage or injury whatever, known or unknown, suspected or unsuspected, resulting from any act or omission
by or on the part of the Releasees, or any of them, committed or omitted on or before the time Employee signs this Agreement. Additionally, Employee in any future claims may not use against Releasees as evidence any acts or omissions by or on the
part of the Releasees, or any of them, committed or omitted on or before the time Employee signs this Agreement, and no such future claims may be based on any such acts or omissions. Also without limiting the generality of the foregoing, Employee
specifically releases the Releasees from any claim for attorneys’ fees. EMPLOYEE ALSO SPECIFICALLY AGREES AND ACKNOWLEDGES EMPLOYEE IS WAIVING ANY RIGHT TO RECOVERY BASED ON STATE OR FEDERAL AGE, SEX, PREGNANCY, RACE, COLOR, NATIONAL ORIGIN,
MARITAL STATUS, RELIGION, VETERAN STATUS, DISABILITY, SEXUAL ORIENTATION, MEDICAL CONDITION OR OTHER ANTI-DISCRIMINATION LAWS, INCLUDING, WITHOUT LIMITATION, TITLE VII OF THE CIVIL RIGHTS ACT OF 1964, THE AGE DISCRIMINATION IN EMPLOYMENT ACT, THE
EQUAL PAY ACT, THE AMERICANS 

  
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WITH DISABILITIES ACT, THE CALIFORNIA FAIR EMPLOYMENT AND HOUSING ACT, THE CALIFORNIA FAMILY RIGHTS ACT, CALIFORNIA LABOR CODE SECTION 970, THE FAMILY AND MEDICAL LEAVE ACT, THE EMPLOYEE
RETIREMENT INCOME SECURITY ACT, THE WORKER ADJUSTMENT AND RETRAINING ACT, THE FAIR LABOR STANDARDS ACT, AND ANY OTHER SECTION OF THE CALIFORNIA LABOR OR GOVERNMENT CODE, ALL AS AMENDED, WHETHER SUCH CLAIM BE BASED UPON AN ACTION FILED BY EMPLOYEE OR
BY A GOVERNMENTAL AGENCY. This Release does not release claims (i) that cannot be released as a matter of law, including, but not limited to, Employee’s right to file a charge with or participate in a charge by the Equal Employment
Opportunity Commission, or any other local, state, or federal administrative body or government agency that is authorized to enforce or administer laws related to employment, against the Company (with the understanding that any such filing or
participation does not give Employee the right to recover any monetary damages against the Company; Employee’s release of claims herein bars Employee from recovering such monetary relief from the Company), (ii) that may arise after the Employee
executes this Agreement; (iii) to indemnification under any agreement between Employee and the Company or under the Company’s certificate of incorporation, bylaws or other organizational documents, each as amended; (iv) under the
Company’s director and officer liability insurance; (v) for vested benefits under the Company’s employee benefit plans; or (vi) by Employee in his capacity as a stockholder of the Company. 

7. Employee agrees and understands as follows: It is the intention of Employee in executing this instrument that it shall be effective as a bar to each and
every claim, demand, grievance and cause of action hereinabove specified. In furtherance of this intention, Employee hereby expressly waives any and all rights and benefits conferred upon Employee by the provisions of Section 1542 of the
California Civil Code and expressly consents that this Agreement shall be given full force and effect according to each and all of its express terms and provisions, including those relating to unknown and unsuspected claims, demands and causes of
action, if any, as well as those relating to any other claims, demands and causes of action hereinabove specified, Section 1542 provides: 
 “A
general release does not extend to claims that the creditor or releasing party does not know or suspect to exist in his or her favor at the time of executing the release and that, if known by him or her, would have materially affected his or her
settlement with the debtor or released party.” 
 Having been so apprised, Employee nevertheless hereby voluntarily elects to and does waive the rights
described in Civil Code section 1542 and elects to assume all risks for claims that now exist in Employee’s favor, known or unknown, that are released under this Agreement. 

8. Employee agrees: (1) the fact of and the terms and conditions of this Agreement; and (2) any and all actions by Releasees taken in accordance
herewith, are confidential, and shall not be disclosed, discussed, publicized or revealed by the parties or their attorneys to any other person or entity, including but not limited to radio, television, press media, newspapers, magazines,
professional journals and professional reports, excepting only the Parties’ accountants, lawyers, immediate family members (mother, father, brother, sister, child, spouse), the persons necessary

  
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to carry out the terms of this Agreement or as required by law. Should Employee be asked about the Disputes or this Agreement, Employee shall limit Employee’s response, if any, by stating
that the matters have been amicably resolved. 
 9. In the event a government agency files or pursues a charge or complaint relating to Employee’s
employment with the Company and/or the Disputes, Employee agrees not to accept any monetary or other benefits arising out of the charge or Complaint. 
 10.
Employee agrees not to make any derogatory, disparaging or negative comments about the Company, its products, officers, directors, or employees. Nothing in this section shall be construed to prevent Employee from providing information to any
governmental agency to the extent required by law, or giving truthful testimony in response to direct questions asked pursuant to a lawful subpoena or other legal process. Further, nothing in this section is intended to prevent any party from
disclosing factual information regarding any claim for sexual harassment, sex discrimination, or retaliation for reporting sexual harassment or sex discrimination. 

11. If any provision of this Agreement or application thereof is held invalid, the invalidity shall not affect other provisions or applications of the
Agreement which can be given effect without the invalid provision or application. To this end, the provisions of this Agreement are severable. 
 12.
Employee agrees and understands that this Agreement may be treated as a complete defense to any legal, equitable, or administrative action that may be brought, instituted, or taken by Employee, or on Employee’s behalf, against the Company or
the Releasees, and shall forever be a complete bar to the commencement or prosecution of any claim, demand, lawsuit, charge, or other legal proceeding of any kind against the Company and the Releasees, 

13. This Agreement and all covenants and releases set forth herein shall be binding upon and shall inure to the benefit of the respective Parties hereto,
their legal successors, heirs, assigns, partners, representatives, parent companies, subsidiary companies, agents, attorneys, officers, employees, directors and shareholders. 

14. The Parties hereto acknowledge each has read this Agreement, that each fully understands its rights, privileges and duties under the Agreement, that each
has had an opportunity to consult and has consulted with an attorney of its choice and that each enters this Agreement freely and voluntarily. 
 15. This
Agreement may not be released, discharged, abandoned, changed or modified in any manner, except by an instrument in writing signed by Employee and an officer of the Company. The failure of any Party to enforce at any time any of the provisions of
this Agreement shall in no way be construed as a waiver of any such provision, nor in any way to affect the validity of this Agreement or any part thereof or the right of any Party thereafter to enforce each and every such provision. No waiver of
any breach of this Agreement shall be held to be a waiver of any other or subsequent breach. 

  
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 16. This Agreement and the provisions contained herein shall not be construed or interpreted for or against
any party hereto because that party drafted or caused that party’s legal representative to draft any of its provisions. 
 17. In the event of
litigation arising out of or relating to this Agreement, the prevailing party shall be entitled to recover reasonable attorneys’ fees and costs. 
 18.
Employee acknowledges Employee may hereafter discover facts different from, or in addition to, those Employee now knows or believes to be true with respect to the claims, demands, liens, agreements, contracts, covenants, actions, suits, causes of
action, wages, obligations, debts, expenses, damages, judgments, orders and liabilities herein released, and agrees the release herein shall be and remain in effect in all respects as a complete and general release as to all matters released herein,
notwithstanding any such different or additional facts. 
 19. The undersigned each acknowledge and represent that no promise or representation not
contained in this Agreement has been made to them and acknowledge and represent that this Agreement and the Employment Agreement contains the entire understanding between the Parties and contains all terms and conditions pertaining to the compromise
and settlement of the subjects referenced herein. For the avoidance of doubt, and notwithstanding anything to the contrary set forth in this Agreement, nothing in this Agreement shall release or modify the Employee’s rights under paragraphs
8.d., 8.e., 9, 10 or 11 of the Employment Agreement (or under the written agreements referenced in paragraph 11.a. of the Employment Agreement). The undersigned further acknowledge that the terms of this Agreement are contractual and not a mere
recital. 
 20. Employee expressly acknowledges, understands and agrees that this Agreement includes a waiver and release of all claims which Employee has
or may have under the Age Discrimination in Employment Act of 1967, as amended, 29 U.S.C. §621, et seq. (“ADEA”). The terms and conditions of Paragraphs 20 through 22 apply to and are part of the waiver and release of ADEA claims
under this Agreement. Company hereby advises Employee in writing to discuss this Agreement with an attorney before signing it. Employee acknowledges the Company has provided Employee at least forty-five days within which to review and consider this
Agreement before signing it. If Employee elects not to use all forty-five days, then Employee knowingly and voluntarily waives any claim that Employee was not in fact given that period of time or did not use the entire forty-five days to consult an
attorney and/or consider this Agreement. 
 21. Within three calendar days of signing and dating this Agreement, Employee shall deliver the signed original
of this Agreement to Violet Torneros (VTorneros@aduro.com) Senior Director, Human Resources of the Company. However, the Parties acknowledge and agree that Employee may revoke this Agreement for up to seven calendar days following
Employee’s execution of this Agreement and that it shall not become effective or enforceable until the revocation period has expired without revocation. The Parties further acknowledge and agree that such revocation must be in writing addressed
to and received by Violet Torneros (VTorneros@aduro.com of the Company not later than midnight on the seventh day following execution of this Agreement by Employee. If Employee revokes this Agreement under this Paragraph, this Agreement shall not be
effective or enforceable and Employee will not receive the benefits described above, including those described in Paragraph 5. 

  
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 22. If Employee does not revoke this Agreement in the timeframe specified in Paragraph 21 above, the
Agreement shall be effective at 12:00:01 a.m. on the eighth day after it is signed by Employee (the “Effective Date”). 
 23. This Agreement is
intended to be exempt from or comply with the requirements of section 409A of the Internal Revenue Code of 1986 as amended (“Section 409A”) and will be interpreted accordingly. While it is intended that all payments and benefits
provided under this Agreement to Employee or on behalf of Employee will be exempt from or comply with Section 409A, the Company makes no representation or covenant to ensure that such payments and benefits are exempt from or compliant with
Section 409A. The Company will have no liability to Employee or any other party if a payment or benefit under this Agreement is challenged by any taxing authority or is ultimately determined not to be exempt from or compliant with
Section 409A. 
 24. This Agreement may be executed in any number of counterparts, each of which so executed shall be deemed to be an original and such
counterparts shall together constitute one and the same Agreement. 
 25. This Agreement shall be construed in accordance with, and be deemed governed by
the Employee Retirement Income Security Act of 1974, as amended, and, to the extent applicable, the laws of the State of Delaware, without reference to the conflict of law provisions thereof. 

I have read the foregoing Separation Agreement and General Release of All Claims, consisting of 6 pages, and I accept and agree to the provisions contained
therein and hereby execute it voluntarily and with full understanding of its consequences. 
 PLEASE READ CAREFULLY. THIS AGREEMENT
CONTAINS A GENERAL RELEASE OF ALL KNOWN AND UNKNOWN CLAIMS. 
  

							
	 Dated:
	 	 October 4, 2020
	  	         
	 	 /s/ Stephen T. Isaacs

		 		  		 	 Stephen T. Isaacs

				
		 		  		 	 Aduro Biotech, Inc.

				
	 Dated:
	 	 October 4, 2020
	  		 	 /s/ Blaine Templeman

		 		  		 	 Name: Blaine Templeman

		 		  		 	 Title: Chief Administrative Officer, Chief Legal Officer

  
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 APPENDIX A 

This separation pay program will occur on October 5, 2020. The decisional unit for this separation pay program includes all officers in the facility at
740 Heinz Avenue, Berkeley, California. All officers in the decisional unit who are being laid off on October 5, 2020 are eligible for the separation pay program. The following is a listing of the departments, job titles, and ages of employees
in the decisional unit who were and were not selected for layoff and offered separation pay in exchange for the release and ADEA waiver in the attached agreement. Only those employees selected for layoff are eligible for the separation pay in
exchange for the release and ADEA waiver. 
  

											
	 Job Title
	  	Age	 	  	Selected	  	Not
Selected	 
	 Chairman, President & CEO
	  	 	71	 	  	1	  			
	 Chief Administrative Officer & Chief Legal Officer
	  	 	54	 	  	1	  			
	 SVP, General Counsel & Secretary
	  	 	45	 	  	1	  			
	 Chief Medical Officer
	  	 	44	 	  	1	  			

  
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 Exhibit 10.4 

CHINOOK THERAPEUTICS, INC. 

CONSULTING AGREEMENT 

This CONSULTING AGREEMENT (this “Agreement”) is made effective as of
                , 2020 (the “Effective Date”), by and between Chinook Therapeutics, Inc., a Delaware corporation (the “Company”) and
                            , (“Consultant”). The Company and Consultant may be referred to
herein individually as “Party” or collectively as “Parties.” 
 1.    Work and
Payment. 
 1.1    Services. Consultant will continue his/her/its work on ongoing transactional matters
directly relevant to the disposition of Company’s non-1301 assets. Specifically, Consultant will continue to supervise and participate in ongoing marketing, product diligence, negotiation and presentation
to the Special Committee of potential transactions related thereto (together with such other related services as the Company may reasonably request from time to time, the “Services”). Consultant hereby agrees to deliver the Services
on the terms set forth herein. Unless otherwise specified in Exhibit A attached hereto (the “Project Assignment”), the manner and means by which Consultant chooses to complete the Services are in Consultant’s sole
discretion and control. In performing the Services, Consultant will use Consultant’s own equipment, tools and other materials at Consultant’s own expense, unless otherwise specified in this Agreement. Consultant may not subcontract or
otherwise delegate Consultant’s obligations under this Agreement. Consultant will perform the Services, and provide the results thereof, with the highest degree of professional skill and expertise. 

1.2    Compensation. The terms and conditions for payment are set forth in the Project Assignment, which is hereby
incorporated by reference into this Agreement. 
 1.3    Expenses. The Company will reimburse Consultant for
reasonable expenses incurred in the performance of the Services; provided that any expenses exceeding $5,000 in the aggregate must be approved in advance by the Company. Consultant must provide copies of receipts for any single expense incurred
greater than $50. Approved expenses will be reimbursed within 30 days of the Company’s receipt of invoices with supporting receipts, to the extent required by this provision. 

2.    Confidential Information. 

2.1    Definition. During the term of this Agreement and in the course of Consultant’s performance hereunder,
Consultant will receive and otherwise be exposed, directly or indirectly, to technical and non-technical confidential information of the Company, including without limitation, information relating to the
Company’s business, strategies, designs, products, services and technologies and any derivatives, improvements and enhancements related to any of the foregoing, or to the Company’s suppliers, customers or business partners (collectively
“Confidential Information”), whether in graphic, written, electronic or oral form. Confidential Information may be labeled or identified at the time of disclosure as confidential or proprietary, or equivalent, but Confidential
Information also includes information which by its context would reasonably be deemed to be confidential and proprietary. “Confidential Information” may also include, without limitation, unpublished patent applications and

  
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other intellectual property filings, ideas, Work Product (as defined below), techniques, works of authorship, models, inventions, compounds, compositions,
know-how, processes, algorithms, software programs, software source documents, formulae, information and trade secrets as well as financial information (including sales costs, profits, pricing methods),
research data, clinical data, bills of material, customer, prospect and supplier lists, investors, employees, business and contractual relationships (including with third parties), business forecasts, sales and merchandising data, and business and
marketing plans and any derivatives, improvements and enhancements related to any of the above. Information the Company provides regarding third parties as to which the Company has an obligation of confidentiality also constitutes “Confidential
Information.” 
 2.2    Restrictions on Use and Disclosure. Consultant acknowledges the confidential and
secret character of the Confidential Information, and agrees and acknowledges that such Confidential Information is the sole, exclusive property of the Company. Accordingly, Consultant agrees not to use or reproduce the Confidential Information
except as reasonably necessary in the performance of this Agreement, and not to disclose, lecture upon or publish all or any part of the Confidential Information in any form to any third party, either during or after the term of this Agreement,
without the prior written consent of the Company. Consultant shall take, at its own expense, all reasonable steps to keep the Confidential Information strictly confidential. Consultant agrees to institute measures to protect the Confidential
Information in a manner consistent with the measures it uses to protect its own sensitive proprietary and confidential information, which shall not be less than a reasonable standard of care. Consultant shall notify the Company upon discovery of any
actual or suspected loss or unauthorized disclosure of the Confidential Information and shall cooperate with Company to take all reasonable steps requested by the Company to prevent, control or remedy any such loss or disclosure. Upon expiration or
any termination of this Agreement, Consultant agrees to cease using, to return to the Company, or at the Company’s sole option, destroy, to the extent practicable, all whole and partial copies and derivatives of the Confidential Information,
whether in Consultant’s possession or under Consultant’s direct or indirect control. 
 2.3    Third-Party
Information. Consultant will need to manage and use the confidential information of third parties while providing the Services and agrees to use reasonable efforts to keep such information secret, and Consultant will not disclose or otherwise
make available to the Company any confidential information received by Consultant under obligations of confidentiality from a third party. 

2.4    Exceptions; Compelled Disclosure. The obligations of confidentiality set forth in Section 2.2 will not
apply to information the Consultant can establish by competent proof: (i) was generally available to the public or otherwise part of the public domain at the time of disclosure; (ii) became generally available to the public or otherwise
part of the public domain after its disclosure and other than through an act or omission of Consultant in violation of any confidentiality restrictions; (iii) was already known to Consultant, without confidentiality restrictions, at the time of
disclosure; (iv) was disclosed to Consultant, without confidentiality restrictions, by a third party who had no obligation not to disclose such information to others; or (v) was developed independently by Consultant without any use of or
reference to the Confidential Information. In the event a court or governmental agency legally compels Consultant to disclose Confidential Information, Consultant will provide reasonable prior written notice of such required disclosure to the
Company and support the Company, at Company’s sole expense, in taking reasonable and lawful actions to avoid and/or minimize the extent of such disclosure. 

  
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 2.5    Defend Trade Secrets Act Notice of Immunity Rights.
Consultant acknowledges that the Company has provided Consultant with the following notice of immunity rights in compliance with the requirements of the Defend Trade Secrets Act: (i) Consultant will not be held criminally or civilly liable
under any Federal or State trade secret law for the disclosure of Confidential Information that is made in confidence to a Federal, State, or local government official or to an attorney for the purpose of reporting or investigating a suspected
violation of law, (ii) Consultant will not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of Confidential Information that is made in a complaint or other document filed in a lawsuit or other
proceeding, if such filing is made under seal, and (iii) if Consultant files a lawsuit for retaliation by the Company for reporting a suspected violation of law, Consultant may disclose the Confidential Information to its attorney and use the
Confidential Information in the court proceeding, if Consultant files any document containing the Confidential Information under seal, and does not disclose the Confidential Information, except pursuant to court order. 

2.6    Consultant Confidential Information. Consultant may share with Company confidential information of
Consultant during the Term. Company agrees to keep such information confidential on the same terms mutatis mutandis as Consultant has agreed in respect of Company Confidential Information. 

3.    Intellectual Property. Company shall be the sole and exclusive owner of, and Consultant hereby assigns to
Company, any and all writings, documents, work product, inventions, developments, improvements, discoveries, know-how, processes, chemical entities, compounds, plans, memoranda, tests, research, designs,
specifications, models and data that Consultant makes, conceives, discovers or develops, either solely or jointly with any other person in performance of the Services (collectively, “Work Product”). Consultant shall promptly
disclose to Company all information relating to Work Product as appropriate as part of the Services and at the request of Company. To the extent, if any, that Consultant has rights in or to any Work Product or any data or inventions developed in
connection with work under this Agreement (“Company IP”), Consultant hereby irrevocably assigns and transfers to Company, and to the extent that an executory assignment is not enforceable, Consultant hereby agrees to assign and
transfer to Company, in writing, from time to time, upon request, any and all right, title, or interest that Consultant has or may obtain in any Work Product and/or Company IP without the necessity of further consideration. Company shall be entitled
to obtain and hold in its own name all copyrights, patents, trade secrets and trademarks with respect thereto. At Company’s request and expense, Consultant shall assist Company in acquiring and maintaining its right in and title to, any Work
Product. Such assistance may include, but will not be limited to, signing applications and other documents, cooperating in legal proceedings, and taking any other steps considered necessary or desirable by Company. 

4.    Representations and Warranties. 

Consultant represents as follows: 

(a)    Consultant has the power and authority to enter into this Agreement; and 

  
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 (c)    Consultant will perform the Services in all material respects in
accordance with applicable law. 
 Company represents as follows: 

(a)    Company has the power and authority to enter into this Agreement and 

(c)    Company will comply in all material respects with all Applicable Law in relation to this Agreement and the
Services. 
 5.    Term and Termination. 

5.1    This Agreement shall begin on the date first written above and shall continue until October 31, 2020 (the
“Term”) unless, as permitted herein, extended by the parties or earlier terminated by a party. The parties may mutually agree in writing to extend the Term for one or more successive calendar months for a fee in respect of each such
calendar month no less than the Fee (as defined in the Project Assignment), which additional fee shall be due and payable on the 15th of the calendar month to which the payment relates. 

5.2    This Agreement may be terminated by either party on fifteen days’ prior written notice to the other party. For
the avoidance of doubt, prior notice is not required by either party for this Agreement to terminate at the conclusion of the Term (including if the Term is extended). In the event of such termination by the Company, Consultant will cease work
immediately after receiving notice of such termination from the Company and will notify the Company of all costs incurred up to the effective date of termination that are reimbursable pursuant to Section 1.3 hereof. The Company agrees to
reimburse Consultant for costs and expenses permitted under this Agreement including pursuant to Section 1.3, 3 or 8 incurred by Consultant in compliance with this Agreement (including Section 1.3) and the Fee (as defined in the Project
Assignment, or as otherwise mutually agreed by the parties in writing) payable for the calendar month in which termination occurs shall be reduced by taking into account the number of business days unworked in the Term after the effective date of
termination, provided that the Fee due and payable for October 2020 shall only be reduced if this Agreement is terminated by Consultant effective a date prior to October 30, 2020. 

6.    Independent Contractor. Consultant’s relationship with the Company will be that of an independent
contractor and nothing in this Agreement should be construed to create a partnership, joint venture, or employer-employee relationship. Except pursuant to the terms of the Indemnity Agreement (defined in Section 8 below), Consultant is not the
agent of the Company and is not authorized to make any representation, warranty, contract, or commitment on behalf of the Company. Consultant will not be entitled to any of the benefits which the Company may make available to its employees, such as
group insurance, profit-sharing or retirement benefits. Consultant is responsible for all personal tax returns and payments required to be filed with or made to any federal, state or local tax authority with respect to Consultant’s performance
of the Services and receipt of fees under this Agreement. The Company will regularly report amounts paid to Consultant by filing Form 1099-MISC with the Internal Revenue Service as required by law. Because Consultant is an independent contractor,
the Company will not withhold or 

  
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make payments for social security, make unemployment insurance or disability insurance contributions, or obtain worker’s compensation insurance on Consultant’s behalf. Consultant agrees
to accept exclusive liability for complying with all applicable state and federal laws governing self-employed individuals, including obligations such as payment of taxes, social security, disability and other contributions based on fees paid to
Consultant under this Agreement. In the event that, notwithstanding this Section 6, Consultant is found by a court of competent jurisdiction to be an employee of the Company, the Parties acknowledge and agree that works of authorship and other
intellectual property that would qualify fully for exemption from assignment under the provisions of Section 2870 of the California Labor Code will not constitute Work Product for the purposes of assignment under Section 3 of this
Agreement. Notwithstanding the foregoing, the Company’s Amended and Restated Severance Plan and Summary Description dated December 9, 2016, as amended, and in particular Sections III(d) and V. of the Severance Plan, shall control with
respect to tax treatment, offset, and the application of Sections 280G and 409A of the Internal Revenue Code to the benefits provided under this Agreement. 

7.    LIMITATION OF LIABILITY. TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, IN NO EVENT WILL CONSULTANT BE
LIABLE TO COMPANY FOR ANY LOST PROFITS OR LOST BUSINESS OR FOR ANY CONSEQUENTIAL, INCIDENTAL, SPECIAL OR INDIRECT DAMAGES OF ANY KIND, WHETHER ARISING IN CONTRACT, TORT OR OTHERWISE, AND REGARDLESS OF WHETHER THE COMPANY HAS BEEN NOTIFIED OF THE
POSSIBILITY OF SUCH DAMAGES. 
 8.    Indemnity. The Indemnity Agreement entered into on June 27, 2019,
effective as of March 11, 2015 between Company and Consultant (the “Indemnity Agreement”) will remain in full force and effect for the Term mutatis mutandis and shall survive the termination of this Agreement with respect to
the activities under this Agreement. 
 9.    General. 

9.1    Assignment. This Agreement may not be assigned. 

9.2    Legal and Equitable Remedies. Each Party will have the right to seek enforcement of this Agreement and any
of its provisions by injunction, specific performance or other equitable relief without prejudice to any other rights and remedies that such Party may have for a breach of this Agreement. 

9.3    Governing Law. The rights and obligations of the Parties under this Agreement will be governed in all
respects by the laws of the State of California without regard to conflict of law principles. 

9.4    Notices. Any notices required or permitted hereunder will be given to the appropriate Party in writing and
will be delivered by personal delivery, electronic mail or by certified or registered mail, return receipt requested, and will be deemed given upon personal delivery, three days after deposit in the mail, or upon acknowledgment of receipt of
electronic transmission. Notices will be sent to the addresses or electronic mail set forth at the beginning of this Agreement or such other address or electronic mail as either Party may specify in writing. 

  
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 9.5    Entire Agreement. This Agreement, together with the
Project Assignment, constitute the Parties’ final, exclusive and complete understanding and agreement with respect to the subject matter hereof, and supersede all prior and contemporaneous understandings and agreements relating to its subject
matter. For the avoidance of doubt, the Indemnity Agreement, the indemnification provisions in the Company’s certificate of incorporation, bylaws or other organizational documents, each as amended, the Separation Agreement between the Company
and Consultant and the provisions of the Retention Agreement dated January 9, 2020 providing Consultant additional time to exercise options remain in full force and effect. 

9.6    Waiver and Modification. This Agreement may not be waived, modified or amended unless mutually agreed upon
in writing by both Parties. 
 9.7    Severability. In the event any provision of this Agreement is found to be
legally unenforceable, such unenforceability will not prevent enforcement of any other provision of this Agreement. 

9.8    Counterparts. This Agreement may be executed in two or more counterparts by facsimile or other reliable
electronic reproduction (including, without limitation, transmission by pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com), each of which will be considered an original, but all of which
together will constitute one and the same instrument. 
 9.9    Survival. In addition to the rights and
obligations of the Parties otherwise accrued as of termination or expiration or provisions that survive by their terms, the rights and obligations of the Parties set forth in Sections 2, 3, 6, 7, 8, and 9 and Exhibit A shall survive the termination
or expiration of this Agreement. 
 [Signature Page Follows] 

  
 6 

 IN WITNESS WHEREOF, the Parties hereto have executed this Agreement as of the
date first set forth above. 
  

									
	CHINOOK THEAPEUTICS, INC.	 		 	CONSULTANT
					
	By:	 	 	 		 	By:	 	 
					
	Name:	 	 	 		 	Name:	 	 
					
	Title:	 	 	 		 		 	

  
 [Signature Page to
Consulting Agreement] 

 Exhibit A 

Project Assignment

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