Document:

Prepared by MERRILL CORPORATION www.edgaradvantage.com

QuickLinks
 -- Click here to rapidly navigate through this document
  

Exhibit 10.20

Confidential treatment requested  

  
 

    CONTRACT MANUFACTURING AGREEMENT    
  

    This CONTRACT MANUFACTURING AGREEMENT (the "Agreement") is entered into as of October 16, 2000 (the "Effective Date"), by and between ICOS Corporation
("ICOS"), a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 22021 20th Avenue SE, Bothell, WA 98021 USA and Seattle
Genetics, Inc. ("SGI"), a corporation organized and existing under the laws of the State of Delaware and having its principal place of business at 22215 26th Avenue S.E., Suite 3000, Bothell,
WA 98021. 

RECITALS  

    WHEREAS, ICOS is in the business of manufacturing and testing pharmaceutical products; and 

    WHEREAS,
SGI is the proprietor of a certain cDNA known as SGN 30 [*], encoding monoclonal antibodies also known as SGN 30 [*]; and 

    WHEREAS,
ICOS has expertise in the development, evaluation and production of monoclonal antibodies for therapeutic use using cell lines; and 

    WHEREAS,
subject to the terms and conditions set forth in this Agreement, SGI wishes to have ICOS manufacture for SGI a pre-commercial pharmaceutical Product (hereinafter
defined); and 

    WHEREAS,
subject to the terms and conditions set forth in this Agreement, ICOS wishes to manufacture Product for SGI. 

    NOW,
THEREFORE, the parties hereto, intending to be legally bound, hereby agree as follows: 

1.  Definitions  

    For purposes of this Agreement, the following terms will have the meanings set forth below: 

    1.1 "Affiliates" means, with respect to any Person, another Person that, directly or indirectly, controls, is controlled
by or is under common control with such Person. The term "control" means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a
Person, whether through the ownership of voting securities, by contract or otherwise. The direct or indirect ownership of at least fifty percent (50%) or, if smaller, the maximum allowed by applicable
law, of the voting securities of a business entity or of an interest in the assets, profits or earnings of a Person shall be deemed to constitute "control" of the Person. 

    1.2 "Applicable Laws" means all applicable ordinances, rules and regulations of any kind whatsoever of any governmental
or regulatory authority, including, without limitation, the FDCA. 

    1.3 "Audit" means a review by SGI or their appointed representatives (such representatives to be reasonably acceptable
to ICOS) of applicable processes, procedures and documents. 

    1.4 "Calendar Quarter" means the three-month period ending on March 31, June 30, September 30 or
December 31. The initial Calendar Quarter will be deemed to begin on the Effective Date and end on the first to occur of March 31, June 30, September 30 or
December 31 of such same year. 

    1.5 "Calendar Year" means the twelve (12) month period ending on December 31. The initial Calendar Year
will be deemed to begin on the Effective Date and end on December 31 of such same year. 

[*]   Confidential treatment requested 

1

 

    1.6 "Cell Line" means a [*] cell line known as [*], which has been
transfected with a [*] containing certain SGI Materials as described in Appendix B, and will be used to provide the Services herein. Any cell bank provided containing
the transfected cell line will be always subject to the license granted under Appendix G herein. 

    1.7 "cGMP" means Good Manufacturing Practices and General Biologics Products Standards as promulgated under the US
Federal Food Drug and Cosmetic Act at 21CFR (Chapters 210, 211, 600 and 610). 

    1.8 "Damages" means any and all reasonable costs, losses, claims, actions, liabilities, fines, penalties, costs and
expenses, court costs, and reasonable fees and disbursements of counsel, consultants and expert witnesses incurred by a party hereto (including interest which may be imposed in connection therewith). 

    1.9 "FDA" means the United States Food and Drug Administration, any comparable agency in any Foreign Jurisdiction, and
any successor agency or entity to any of the foregoing that may be established hereafter. 

    1.10 "FDCA" means the Federal Food, Drug and Cosmetic Act (21 U.S.C. § 301 et
seq.). 

    1.11 "FOB" means ICOS has fulfilled its obligation to deliver when it has made the object of delivery available at its
premises to SGI or SGI's agent (or to SGI's carrier). For the avoidance of doubt, unless otherwise agreed in writing, ICOS is not responsible for loading the object of delivery on to the vehicle
provided by SGI or SGI's agent (or to ICOS's nominated carrier) or for delaying the object of delivery for export. 

    1.12 "Foreign Jurisdiction" means any jurisdiction where Product will be used by SGI, not governed by the United States
or any political subdivision thereof. 

    1.13 "ICOS Know-How" means unpatented and/or unpatentable technical information, including ideas, concepts,
inventions, discoveries, data, designs, formulas, specifications, procedures for experiments and
tests and other protocols, results of experimentation and testing, fermentation and purification techniques, and assay protocols owned by ICOS as of the Effective Date which may be necessary for the
practice of the ICOS-Patent Rights and which ICOS has the right to license. ICOS Know-How shall not include the ICOS-Patent Rights. All ICOS Know-How
shall be Confidential Information of ICOS. 

    1.14 "ICOS Patent Rights" mean the patent applications and patents listed on Exhibit A to Appendix G
hereto and all divisions, continuations, continuations-in-part, and substitutions thereof; all foreign patent applications corresponding to the preceding applications; and all
U.S. and foreign patents issuing on any of the preceding applications, including extensions, reissues, and re-examinations. 

    1.15 "Manufacturing Specifications" means the specifications for manufacturing the Product. Prior to the initiation of
the first cGMP manufacturing run an Appendix C-1 signed by both parties setting forth the initial Manufacturing Specifications shall be appended to this Agreement and shall contain
at a minimum a collection of documents containing certain specifications, procedures, assay methods (QC Release Tests), personnel contacts and any other information as may be needed and agreed by the
parties relating to the manufacture of Product by ICOS for SGI. This Appendix C-1 shall also contain a statement to be agreed and acknowledged by ICOS and SGI that SGI adopts the
initial Manufacturing Specifications as its own specification in conformance with Clause 6.7 herein. Any changes or additions to the Manufacturing Specifications shall be made with the written
approval of SGI. 

    1.16 "NDA" means New Drug Application or any comparable application required by a Foreign Jurisdiction filed for the
Product by SGI with the FDA and all subsequent submissions, supplements or amendments related thereto. 

2

 

    1.17 "Person" means a natural person, a corporation, a partnership, a trust, a joint venture, a limited liability
company, any governmental authority or any other entity or organization. 

    1.18 "Price" means the price specified in Appendix E for the Services. 

    1.19 "Process" means the process for the production of the Product from the Cell Line using the Manufacturing
Specifications, including any improvements thereto from time to time made as a result of the Services. 

    1.20 "Product" means a monoclonal antibody derived from the Cell Line, manufactured by a process utilizing the
Manufacturing Specifications, and incorporating technology licensed from ICOS in Appendix G. 

    1.21 "Product Specifications" means the product specifications as described in Appendix C. 

    1.22 "Services" means all or any part of the services the subject of this Agreement or Proposal (including, without
limitation, cell culture evaluation, purification evaluation, master, working and extended cell bank creation, and sample and bulk production), particulars of which are set out in Appendix A. 

    1.23 "SGI-Patent Rights" means all patents and patent applications of any kind throughout the world relating
to the Process which from time to time SGI is the owner of or is entitled to use. 

    1.24 "SGI Information" means all confidential, technical and other information not known to ICOS and/or not in the
public domain relating to the Cell Line, the Process and the Product, from time to time supplied by SGI to ICOS, or arranged by SGI to be supplied by a third party (such as a prior manufacturer) to
ICOS. 

    1.25 "SGI Know-How" means all technical and other information relating to the Process known to SGI from time
to time other than confidential SGI Information and information in the public domain. 

    1.26 "SGI Materials" means the Materials supplied by SGI to ICOS (if any) and identified as such by Appendix B
hereto. 

    1.27 "SGI Technology" means all of SGI's patents, technology, know-how and proprietary information necessary
to manufacture the Product. 

    1.28 "SGI Tests" means the tests to be carried out on the Product immediately following receipt of the Product by SGI,
particulars of which are set out in Appendix C. 

    1.29 "Special Term" means any term additional or supplemental to this Agreement from time to time agreed to in writing
between ICOS and SGI. Particulars of any Special Terms are set out in Appendix F. 

    1.30 "Terms of Payment" means the terms of payment specified in Appendix E. 

    1.31 "Testing Laboratories" means any third party instructed by ICOS to carry out tests on the Cell Line or the Product. 

    1.32 "United States" means the fifty (50) states, the District of Columbia and all of the territories of the
United States of America. 

2.  Supply by SGI  

    2.1 Prior
to or immediately following the Effective Date of the Agreement SGI shall supply to ICOS, SGI Information, together with full details of any hazards relating
to SGI Materials, their storage and use. On review of this SGI Information, SGI Materials shall be provided to ICOS at ICOS's request when ICOS has satisfactorily determined that SGI Materials do not
pose a hazard to ICOS. SGI shall assist ICOS in making such determination, but in no way be responsible for deciding 

3

 

the safety of the SGI Materials to ICOS's facilities. All property rights in the SGI Information, SGI Technology and/or SGI Materials supplied to ICOS shall remain vested in SGI. 

    2.2 SGI
hereby grants ICOS the non-exclusive right to use the SGI Materials, SGI Information, SGI Know-how and SGI Technology for the sole
purpose of providing the Services. ICOS hereby undertakes not to use SGI Materials, SGI Information, SGI Know-how or SGI Technology (or any part thereof) for any other purpose. 

    2.3 ICOS
shall: 

    2.3.1  at
all times use all reasonable endeavors to keep the SGI Materials secure and safe from loss or damage but in no case in a lesser manner than
ICOS stores its own material of similar nature; 

    2.3.2  not
transfer to a third party any part of the SGI Materials or the Product, except save for the purpose of any tests at the Testing Laboratories,
provided, that, SGI is given prior notification or if SGI has given prior written consent to such transfer; and 

    2.3.3  provide
that such Testing Laboratories are subject to obligations of confidence materially in the form of those obligations of confidence imposed
on ICOS under this Agreement. 

    2.4 SGI
warrants to ICOS that SGI is and shall at all times throughout the duration of the Agreement remain entitled to supply the SGI Materials, SGI Information and
SGI Know-how to ICOS for the performance of the Services. 

    2.5 SGI
warrants that the use by ICOS of SGI Materials, SGI Information and SGI Know-how for the Services will not infringe or is not alleged to infringe
any rights (including, without limitation, any intellectual or other proprietary rights) vested in any third party. 

    2.6 SGI
undertakes to indemnify and hold harmless and to maintain ICOS promptly indemnified and held harmless against any loss, damage, costs and expenses of any nature
(including court costs and legal fees incurred by ICOS or ordered as payable by ICOS), whether direct or consequential, and whether or not foreseeable or in the contemplation of ICOS or SGI, that ICOS
may suffer arising out of or incidental to any breach of the warranties given in Clauses 2.4 and 2.5 above or any claims alleging ICOS's use of the Cell Line, SGI Materials, SGI Information, SGI
Know-how, or the Manufacturing Specifications infringes any rights (including, without limitation, any intellectual or other proprietary rights) vested in any third party (whether or not
SGI knew or should have known about such alleged infringement); provided, however, SGI shall not be responsible for such indemnification if ICOS infringes any rights of any third parties by
application of its production techniques while performing the Services save where such application or production technique has been developed as part of the Services. For the purposes of Sections 2.6
and 2.7, the term, production technique(s), is limited to all and any physical arrangement and use of plant and equipment in the provision of Services. 

    2.7 ICOS
undertakes to indemnify and hold harmless and to maintain SGI promptly indemnified and held harmless against any loss, damage, costs and expenses of any nature
(including court costs and legal fees incurred by SGI or ordered as payable by SGI), whether direct or consequential, and whether or not foreseeable or in the contemplation of SGI or ICOS, that SGI
may suffer arising from the application of ICOS's production techniques while performing the Services save where such application or production technique has been developed as part of the Services;
provided, however, ICOS shall not be responsible for such indemnification where such application or production technique provided as part of the Services is supplied by SGI. For the avoidance of doubt
where ICOS's application or production techniques, existed prior to the effective date of this Agreement, are not developed as part of the Services hereto and whether or not included in the
Manufacturing Specifications, then they are covered by ICOS's undertaking of indemnity and hold harmless. 

4

 

    2.8 Notwithstanding the above, ICOS shall be at liberty to use SGI Information as it sees fit in providing the Services subject to nondisclosure pursuant to
Clause 7. 

    2.9 The
obligations of each party under this Clause 2 shall survive the termination of the Agreement for whatever reason. 

3.  Provision of the Services  

    3.1 ICOS
shall diligently perform the Services as provided in Appendix A and shall use all reasonable commercial efforts to achieve the estimated schedules,
specifications and amounts of Product. Furthermore, ICOS shall keep SGI regularly informed of any changes to the estimated schedules for performance of the Services and provide a monthly report, in a
form agreed by the parties. 

    3.2 Due
to the unpredictable nature of the biological processes involved in the Services, the schedules set down for the performance of the Services (including, without
limitation, the dates for production and delivery of Product) set out in Appendix D are estimates only. 

    3.3 In
the event that ICOS is unable to, or notifies SGI, in writing, that it is unable, for any reason, except events of Force Majeure where Section 9.1 of this
Agreement shall be applicable, to supply agreed quantities of Product by [*], SGI may at its discretion, seek to manufacture or have manufactured
by a third party designated by SGI that quantity of the Products required by SGI that ICOS is unable to supply. Provided however, that prior to manufacture of Product by a third party, SGI and ICOS
negotiate in good faith the supply of undelivered Product by ICOS to SGI at a future date agreed upon by the parties. If the parties cannot agree on a time period for delivery of Product and SGI
determines to manufacture or have manufactured by a third party such Products, ICOS will supply SGI and/or any such third party all reasonably available information and data relating to the
Manufacturing Specifications. 

    3.4 Delivery
of bulk Product shall be FOB ICOS's premises. Risk in and title to bulk Product shall pass on delivery. Transportation of bulk Product, whether or not
under any arrangements made by ICOS on behalf of SGI, shall be made at the sole risk and expense of SGI. In the case where SGI accepts ICOS Product tests (QC Release Tests) and shipment is to be made
to a third party, "delivery" for the purposes of risk in and title to bulk Product, shall occur upon the signed acceptance of ICOS Product tests (QC Release Tests) by SGI. Unless otherwise agreed
between the parties in writing, ICOS will tender delivery to SGI upon completion of all QA and QC tests approximately six (6) to eight (8) weeks following completion of manufacture. 

    3.5 Unless
otherwise agreed, ICOS shall package and label Product for FOB delivery in accordance with its standard operating procedures. It shall be the responsibility
of SGI to provide prior written notice to ICOS of any special packaging and labeling requirements for Product. All additional costs and expenses (including reasonable profit) of whatever nature
incurred by ICOS in complying with such special requirements shall be charged to SGI in addition to the Price. 

    3.6 Upon
completion of the Services, or as soon thereafter as can be mutually agreed, ICOS will deliver to SGI a cell bank, generated by ICOS, comprised of the Cell
Line and used to provide the Services herein. 

    3.7 Joint
Communication on Manufacturing: ICOS and SGI shall communicate and cooperate on a regular basis during the provision of Services herein and in the event that
the parties observe the need for a regular and active committee, such body shall be established and meet regularly to discuss and communicate the progress of the Services. 

5

 

4.  SGI Tests and Return Procedures  

    4.1 Except
where SGI has accepted ICOS Product tests and provided written notice to ICOS of such acceptance, promptly following delivery of Product, SGI shall carry out
SGI Tests. PROVIDED ALWAYS that the Product Specifications for such Product has been agreed between the parties hereto. If SGI Tests show that the Product fails to meet Product Specifications, SGI
shall give ICOS written notice thereof as soon as practicable but in no case later than [*] ([*]) [*] from the date of FOB
delivery of the Product and shall return such Product to ICOS's premises for further testing. In the absence of such written notice Product shall be deemed to have been accepted by SGI as meeting
Product Specifications. If ICOS agrees that Product returned to ICOS fails to meet Product Specifications and that such failure is not due (in whole or in part) to acts or omissions of SGI or any
third party after FOB delivery of such Product, ICOS shall at SGI's discretion replace such Product at its own cost and expense. ICOS shall be entitled to consider its other obligations and its
commercial commitments to third parties in the timing of such replacement. SGI acknowledges that there may, therefore, be a delay in the timing of the replacement of such Product; provided, however,
that such delay shall not exceed [*] from date of return to ICOS. 

    FOR
THE AVOIDANCE OF DOUBT, WHERE THE SPECIFICATION HAS NOT BEEN AGREED BY THE PARTIES HERETO ICOS SHALL BE OBLIGED ONLY TO USE ITS REASONABLE ENDEAVORS TO PRODUCE PRODUCT THAT MEETS
DRAFT PRODUCT SPECIFICATIONS. 

    4.2 If
there is any dispute concerning whether Product returned to ICOS fails to meet Product Specifications or whether such failure is due (in whole or in part) to
acts or omissions of SGI or any third party after FOB delivery of such Product, such dispute shall be referred for decision to an independent expert (acting as an expert and not as an arbitrator) to
be appointed by agreement between ICOS and SGI. 

    The
costs of such independent expert shall be borne by the party initiating the dispute. The decision of such independent expert shall be in writing and, save for obvious and material
error, shall be binding on both ICOS and SGI. 

    4.3 In
the event that the parties hereto agree that a shipment or batch of Product fails to meet Product Specifications, the entire shipment or batch of Product that
failed to meet Product Specifications shall either be returned to ICOS or destroyed, at ICOS's option. 

    4.4 The
provisions of Clauses 4.1 and 4.2 shall be the sole remedies available to SGI in respect of Product that fails to meet Product Specifications. 

5.  Price and Terms of Payment  

    5.1 SGI
shall pay the Price in accordance with the Terms of Payment all as specified in Appendix E. 

    5.2 Unless
otherwise indicated in writing by ICOS, all prices and charges are exclusive of State Sales Tax or of any other applicable taxes, levies, duties and fees of
whatever nature imposed by or under the authority of any government or public authority, which shall be paid by SGI (other than taxes on ICOS's income). All invoices are strictly net and payment must
be made within thirty (30) days of date of invoice. Payment shall be made without deduction, deferment, set-off, lien or counterclaim of any nature. 

    5.3 In
default of payment on due date interest shall accrue on a day to day basis with effect from the date which is [*]
([*]) [*] after the due date for payment on any amount overdue at the maximum rate allowable under Washington State Law. 

6

 

6.  Warranty and Limitation of Liability  

    6.1 ICOS
warrants that: 

    6.1.1  the
Services shall be performed in accordance with Clause 3.1; and 

    6.1.2  the
Product shall meet Product Specifications, except where the Product Specifications has not been agreed between the parties hereto in which
case ICOS shall be obliged only to use its reasonable commercial efforts to produce Product that meets draft Product Specifications. 

    6.1.3  the
Product delivered to SGI pursuant to this Agreement shall conform to the Product Specifications and that such Product shall (i) be
free from defects in material and workmanship, (ii) be manufactured in accordance with cGMP and (iii) be manufactured in accordance with Appendix C hereof. 

    6.2 Clause 6.1
is in lieu of all conditions, warranties and statements in respect of the Services and/or the Product whether expressed or implied by statute,
custom of the trade or otherwise (including but without limitation any such condition, warranty or statement relating to the description or quality of the Product, its fitness for a particular purpose
or use under any conditions whether or not known to ICOS) and any such condition, warranty or statement is hereby excluded. ICOS MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, WITH RESPECT TO THE
PRODUCT. ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE ARE HEREBY DISCLAIMED BY ICOS. IN NO
EVENT SHALL ICOS BE LIABLE FOR INDIRECT, INCIDENTAL OR COMMERCIAL CONSEQUENTIAL DAMAGES. 

    6.3 Without
prejudice or modification to the terms of Clauses 6.1 and 6.2 the liability of ICOS to SGI, its permitted assigns and successors in interest, for any loss
suffered by SGI or its permitted assigns and successors in interest, arising as a direct result of a breach of this Agreement, or of any other liability, including without limitation,
misrepresentation and negligence (whether active, passive or imputed), arising out of the Agreement and Services provided thereunder, including without limitation the production and/or supply of the
Product, shall be limited to the payment of damages which shall not exceed in US Dollars THE PRICE FOR SERVICES PAID BY SGI UNDER THE AGREEMENT save in the event and to the extent such damages are
caused by ICOS's willful or intentional breach of this Agreement or willful or intentional misconduct in the performance of the Services. 

    6.4 Subject
to Clause 6.3, ICOS shall not be liable for the following loss or damage howsoever caused (even if foreseeable or in the contemplation of ICOS or
SGI): 

    6.4.1  loss
of profits, business or revenue suffered by SGI or any other person who may be subrogated to, or assigned rights in the loss or damage; or 

    6.4.2  special,
indirect or consequential loss, whether suffered by SGI or any other person. 

    6.5   SGI
shall indemnify and hold harmless and maintain ICOS indemnified and held harmless against all Damages in respect of: 

    6.5.1  any
product liability in respect of Product; and 

    6.5.2  any
negligent (active, passive or imputed), gross negligence or intentional act or omission of SGI in relation to the use, processing, storage or
sale of the Product. 

    6.6   Except
as expressly granted in Appendix G and the right allowed to transfer the manufacturing process in Sections 3.3 and 9.1, no express or
implied license is granted by this Agreement. 

    6.7 SGI
represents and warrants that unless already expressly agreed in a written and executed document immediately prior to the initiation of the first cGMP
manufacturing run, SGI will adopt the 

7

 

initial Manufacturing Specifications as its own specification. Any changes or additions to the Manufacturing Specifications shall be made with the written approval of SGI. 

    6.8 The
obligations of SGI under this Clause 6 shall survive the termination for whatever reason of the Agreement. 

7.  Confidentiality  

    7.1 SGI
acknowledges that ICOS Know-How, and ICOS acknowledges that SGI Information, SGI Know-How, SGI Materials, or SGI Technology with which
each is supplied by the other pursuant to the Agreement, subject to Clause 7.4, in circumstances imparting an obligation of confidence and each agrees to keep such ICOS Know-How or
such SGI Information, SGI Know-How, SGI Materials, or SGI Technology confidential and to respect the other's proprietary rights therein and not at any time for any reason whatsoever to
disclose or permit such ICOS Know-How or such SGI Information, SGI Know-How, SGI Materials, or SGI Technology to be disclosed to any third party save as expressly
provided herein and not to use such ICOS Know-How or SGI Information, SGI Know-How, SGI Materials, or SGI Technology for any other purpose other than as expressly provided
herein. 

    7.2 SGI
and ICOS shall each ensure that all their respective employees, consultants and contractors having access to confidential ICOS Know-How or
confidential SGI Information, SGI Know-How, SGI Materials, or SGI Technology shall be subject to the same obligations of confidence as the principals pursuant to Clause 7.1 and
shall be subject to written confidentiality agreements in support of such obligations. 

    7.3 ICOS
and SGI each undertake not to disclose or permit to be disclosed to any third party, or otherwise make use of or permit to be made use of, any trade secrets or
confidential information relating to the technology, business affairs or finances of the other, any subsidiary, holding company or subsidiary or any such holding company of the other, or of any
suppliers, agents, distributors, licensees of the other to which either party comes into possession of under this Agreement, except as specifically stated in Appendix G or agreed between the
parties in writing. 

    7.4 The
obligations of confidence referred to in this Section 7 shall not extend to any information which: 

    7.4.1  is
or becomes generally available to the public otherwise than by reason of a breach by the recipient party of the provisions of this
Section 7; 

    7.4.2  is
lawfully known to the recipient party prior to its receipt from the other; 

    7.4.3  is
subsequently disclosed to the recipient party without being made subject to an obligation of confidence by a third party that does not have a
prior obligation of confidence to SGI or ICOS, as the case may be; or 

    7.4.4  which
may be required to be disclosed under any statutory, regulatory or similar legislative requirement, subject to the imposition of
obligations of confidentiality to the extent allowed and provided further that each party shall, unless prohibited by law, use reasonable efforts to notify the other party of such compelled disclosure
prior to such disclosure in order to seek injunctive or any other relief provided in law or equity. 

    7.5 SGI
acknowledges that: 

    7.5.1  ICOS
Know-How is vested in ICOS; and 

    7.5.2  SGI
shall not at any time have any right, title, license or interest in or to ICOS Know-How or any other intellectual property rights
relating to the Process which are vested in ICOS or to which ICOS is otherwise entitled, except as specifically provided in Appendix G. 

8

 

    7.6 ICOS
acknowledges that: 

    7.6.1  SGI
Information, SGI Materials, SGI Technology, SGI Know-How and SGI-Patent Rights are vested in SGI; and 

    7.6.2  save
as provided herein ICOS shall not at any time have any right, title, license or interest in or to SGI Information or any other intellectual
property rights vested in SGI or to which SGI is entitled. 

    7.7 The
obligations of ICOS and SGI under this Section 7 shall survive the termination of the Agreement for whatever reason. 

8.  Termination  

    8.1 If
it becomes apparent to either ICOS or SGI at any stage in the provision of the Services that it will not be possible to complete the Services for scientific or
technical reasons, a sixty (60) day period shall be allowed for discussion to resolve such problems. 

    If
such problems are not resolved at the end of such sixty (60) day period, ICOS and SGI shall each have the right to terminate the Agreement. In the event of such termination, SGI
shall pay to ICOS a termination sum calculated by reference to all the Services performed by ICOS prior to such termination (including a pro rata proportion (as demonstrated by signed timesheets in so
far as they are applicable) of the Price for any stage of the Services which is in process at the date of termination) and all expenses reasonably incurred by ICOS in giving effect to such
termination, including the costs of terminating any commitments entered into under the Agreement, such termination sum not to exceed the Price. Provided however, that if the termination sum is less
than the amount of any advance payments made by SGI against the performance of the Services a payment in sum equal to the residue of such advance payments shall be made to SGI. 

    8.2 SGI
shall be entitled to terminate this Agreement at any time for any reason by sixty (60) day notice to ICOS in writing providing that any termination or
cancellation agreed between the parties hereto has been paid. 

    In
the event of SGI serving written notice to terminate this Agreement which notice is expressly to be given pursuant to this Clause 8.2, SGI shall: 

    8.2.1  pay
ICOS a termination sum calculated by reference to all the Services performed by ICOS prior to such termination (including a pro rata
proportion (as demonstrated by signed timesheets in so far as they are applicable) of the Price for any stage of the Services which is in process at the date of termination) and all expenses
reasonably incurred by ICOS in giving effect to such termination, including the costs of terminating any commitments entered into under the Agreement such termination sum not to exceed the Price plus
any changes. Provided however, that if the termination sum is less than the amount of any advance payments made by SGI against the performance of the services a payment in sum equal to the residue of
such advance payments shall be made to SGI; and 

    8.2.2  In
the event notice to terminate this Agreement pursuant to this Clause 8.2 is issued to ICOS later than December 1, 2000, SGI
shall pay ICOS a sum equal to the full price minus the cost of materials required for that stage, or those stages, in question which payment shall fall due to ICOS on or before the date of termination
of the Services. 

9

 

    8.3 ICOS
and SGI may each terminate the Agreement forthwith by notice in writing to the other upon the occurrence of any of the following events: 

    8.3.1  if
the other commits a breach of the Agreement which (in the case of a breach capable of remedy) is not remedied within sixty (60) days of the
receipt by the other of written notice identifying the breach with specificity and requiring its remedy; or 

    8.3.2  if
the other ceases for any reason to carry on business or convenes a meeting of its creditors or has a receiver or manager appointed in respect
of all or any part of its assets or is the subject of an application for an administration order or of any proposal for a voluntary arrangement or enters into liquidation (whether compulsorily or
voluntarily) or undergoes any analogous act or proceedings under foreign law; provided, however, either party may merge with or into another equity pursuant to which the obligations of this Agreement
will be assumed or effect the sale of all its assets or substantially all of its assets pursuant to which the acquiring party will assume such party's obligations under this Agreement without notice
to or waiver by the other party. 

    8.4 Upon
the termination of the Agreement for whatever reason: 

    8.4.1  ICOS
shall promptly return all SGI Information to SGI and shall dispose of or return to SGI, SGI Materials and any materials therefrom, as
directed by SGI; 

    8.4.2  SGI
shall promptly return to ICOS all ICOS Know-How it has received from ICOS; 

    8.4.3  SGI
shall not thereafter use or exploit the ICOS Know-How in any way whatsoever for production by SGI, or production by a
third-party. If SGI determines to manufacture or have manufactured by a third party such Products, ICOS will give SGI and/or any such Third Party all reasonably necessary information and cooperation
to enable SGI or such third party to manufacture the Products in connection with the Manufacturing Specifications. 

    8.4.4  save
to the extent expressly stated elsewhere in this Agreement, ICOS may thereafter use or exploit the ICOS Know-How in any way
whatsoever without restriction; and 

    8.4.5  ICOS
and SGI shall do all such acts and things and shall sign and execute all such deeds and documents as the other may reasonably require to
evidence compliance with this Clause 8.4. 

    8.5 Termination
of the Agreement for whatever reason shall not affect the accrued rights of either ICOS or SGI arising under or out of this Agreement and Clauses 2, 6,
7, and 8 and any definitions in Clause 1 required to interpret such surviving provisions, and all provisions which are expressly to survive the Agreement or have a continuing obligation shall
remain in full force and effect. Further, Appendix G shall survive termination of this Agreement and shall exist as a complete and separate agreement. 

9.  Force Majeure  

    9.1 Neither
ICOS nor SGI shall be deemed to be in default nor be liable for loss, damage, or delay in performance, when and to the extent due to causes beyond its
reasonable control or from fire, strike, labor difficulties, insurrection or riot, embargo, or inability to obtain materials from usual sources, or any other unforeseeable cause or causes beyond the
reasonable control and without the fault or negligence of the party so affected, or from defects or delays in the performance of its suppliers or subcontractors due to any of the foregoing enumerated
causes. If ICOS is prevented or delayed in the performance of any of its obligations under the Agreement by Force Majeure and shall give written notice thereof to SGI specifying the matters
constituting Force Majeure together with such evidence as ICOS reasonably can give and specifying the period for which it is estimated that such prevention or delay will continue, ICOS shall be
excused from the performance or the punctual 

10

 

performance of such obligations as the case may be from the date of such notice for so long as such cause of prevention or delay shall continue, provided that within [*]
([*]) days from the date of such notice, ICOS shall provide SGI with written notice of the anticipated date of resumption of performance. In the event that the anticipated date
of such resumption is greater than [*] ([*]) months from the date of the original notice, SGI may invoke the remedy of third party manufacture provided
in Section 3.3 herein or terminate this Agreement. 

10.  Governing Law, Jurisdiction and Enforceability  

    10.1   This
Agreement shall be governed and interpreted, and all rights and obligations of the parties shall be determined, in accordance with the laws
of the State of Washington and the United States of America without regards to principles of conflicts of law. 

    10.2   No
failure or delay on the part of either ICOS or SGI to exercise or enforce any rights conferred on it by the Agreement shall be construed or
operate as a waiver thereof nor shall any single or partial exercise of any right, power or privilege or further exercise thereof operate so as to bar the exercise or enforcement thereof at any time
or times thereafter of any other right. 

    10.3   The
illegality or invalidity of any provision (or any part thereof) of the Agreement shall not affect the legality, validity or enforceability of
the remainder of its provisions or the other parts of such provision as the case may be and the Agreement shall continue in full force and effect without such provision. 

11.  Miscellaneous  

    11.1   Neither
party shall be entitled to assign, or in any way transfer the benefit and/or the duties of this Agreement without the prior written
consent of the other which consent shall not be unreasonably withheld or delayed, except that either party shall be entitled without the prior written consent of the other to assign, transfer, charge,
subcontract, deal with or in any other manner make over the benefit and/or burden of this Agreement to an Affiliate, or to any limited liability partner or to any [*] company
of which the party in question is the beneficial owner of [*] percent ([*]%) of the issued share capital thereof or to any company with which the party
in question may merge or to any company to which that party may transfer its assets and undertakings. 

    11.2   The
text of any press release or other communication to be published by or in the media concerning the subject matter of the Agreement shall
require the prior written approval of ICOS and SGI. 

    11.3  Notices.  All notices, requests, demands, waivers, consents, approval or other communications to
any party hereunder shall be in writing and shall be deemed to have been duly given if delivered personally to such party or sent to such party by recorded electronic transmission (facsimile) or by
registered or certified mail, postage prepaid, to its address as shown below: 

    SGI:      Seattle
Genetics, Inc.

22215 26th Avenue S.E., Suite 3000

Bothell, WA 98021

Attention: H. Perry Fell 

    ICOS:     ICOS
Corporation

22021 20th Avenue S.E.

Bothell, WA 98021

Attention: Legal Department 

or
to such other address as the addressee may have specified in a notice duly given to the sender as provided herein. Such notice, request, demand, waiver, consent, approval or other communications
will 

11

 

be deemed to have been given as of the date so delivered, telegraphed, telexed, or five (5) days after so mailed. 

    11.4  Independent Contractor.  Each party shall be and shall endeavor to act as the independent
contractor of the other party. Neither party shall be the legal agent of the other for any purpose whatsoever and therefore has no right or authority to make or underwrite any promise, warranty or
representation, to execute any contract or otherwise to assume any obligation or responsibility in the name of or on behalf of the other party, except to the extent specifically authorized in writing
by the other party. Neither of the parties hereto shall be bound by or liable to any third persons for any act or for any obligation or debt incurred by the other toward such third party, except to
the extent specifically agreed to in writing by the party so to be bound. 

    11.5  Headings.  All section headings and numbering contained in this Agreement are for convenience of
reference only, do not form a part of this Agreement and shall not affect in any way the meaning or interpretation of this Agreement. 

    11.6  Entire Agreement.  The Agreement embodies the entire understanding of ICOS and SGI and there are no
promises, terms, conditions or obligations, oral or written, expressed on implied, other than those contained in the Agreement. The terms of the Agreement shall supersede all previous agreements (if
any) which may exist or have existed between ICOS and SGI relating to the Services. 

    12.  Other Terms.  The parties agree to such other product specific terms and conditions as set forth in
Appendix F. 

    IN
WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first above written. 

	ICOS CORPORATION	 	SEATTLE GENETICS, INC.
	

By:	
 	

/s/ GARY WILCOX   
 Name: Gary Wilcox

Title: EVP, Operations	
 	

By:	
 	

/s/ H. PERRY FELL   
 Name: H. Perry Fell

Title: C.E.O.

12

 
 

APPENDIX E
  Price and Payment Terms    
  

	Stage
 
	 	Terms
	 	Estimated Date

of Payment
	 	Total Price

for Stage

	Cell Line & Process Development	 	$[*] upon signing of the agreement1; $[*] if decision is made to continue development following titer determinations from CHO cells;	 	[*]

[*]	 	$[*]
	 	 	$[*] upon decision to move forward with process development for either SGN 30 $[*];	 	[*]	 	 
	 	 	$[*] at completion of Cell Line & Process Development stage as described in Appendix A, Section 2	 	[*]	 	 
	

Serum-free Cell Line Development	
 	

$[*] at stage initiation;	
 	

[*]	
 	

$[*]
	

 	
 	
Incentive payments:

Based on baseline titer of [*], $[*] for each titer improvement of [*] above baseline up to [*]. (Maximum incentive payment of $[*])	
 	

 	
 	

 
	

 	
 	

[*]% due upon delivery of process and cell-line to SGI or Third Party manufacturer;	
 	

[*]	
 	

 
	

 	
 	

[*]% due upon first entry in man of resulting product.	
 	

[*]	
 	

 
	

Manufacturing (Including Transfer and Scale-Up; Development run and Production runs)2,3	
 	

$[*] at initiation of Process Transfer to Manufacturing and Scale-up stage as described in Appendix A, Section 3.1.1;	
 	

[*]	
 	

$[*]
	

 	
 	

[*]% of balance at initiation of Development run4;	
 	
[*]	
 	

 
	 	 	[*]% of balance at [*] GMP Production run #1;	 	[*]	 	 
	 	 	[*]% of balance at [*] GMP Production run #2;	 	[*]	 	 
	 	 	[*]% of balance at Lot Release.	 	[*]	 	 

1 Includes
$[*] non-refundable payment made on [*]. 

2 Seattle
Genetics will bear the cost of the resins needed for the process to an agreed upon amount. 

3 ICOS
will deliver [*] gm of cGMP antibody and suitable documentation to support regulatory filings. If ICOS produces additional cGMP antibody,
Seattle Genetics can purchase additional amounts greater than [*] gm at the rate of $[*]/gm. 

4 Initiation
of Development run is defined as inoculation of cell line into seed-train bioreactors. 

[*]   Confidential
treatment requested 

 
 
 

APPENDIX G
  NON-EXCLUSIVE LICENSE AGREEMENT    
  

    This Non-exclusive License Agreement (the "Agreement"), effective as of October 16th, 2000 (The "Effective Date"), is entered
into by and between ICOS Corporation, a Delaware corporation having offices at 22021 20th Avenue SE, Bothell, WA 98021, U.S.A., ("ICOS"), and Seattle
Genetics, Inc., a Delaware corporation having offices at 22215 26th Avenue S.E., Suite 300, Bothell, WA 98021 ("LICENSEE"). All references to
LICENSEE in this Agreement shall include its Affiliates (as such term is defined below). 

 
 

BACKGROUND    
  

    A.  ICOS
is the owner of certain Patent Rights (as defined below) and LICENSEE wishes to acquire a non-exclusive license under the Patent Rights for use in
the Field; and 

    B.  ICOS
is willing to grant LICENSEE such a non-exclusive license, on the terms and conditions set forth below. 

    NOW,
THEREFORE, in consideration of the promises and the mutual covenants hereinafter recited, the parties agree as follows: 

 
 

ARTICLE 1—DEFINITIONS    
  

    In this Agreement, the following terms shall have the meanings set forth in this Article. 

    1.1 "Affiliate" means any corporation or other entity which is directly or indirectly controlling, controlled by or
under common control with a party hereto. For the purpose of this Agreement, "control" shall mean the direct or indirect ownership of at least fifty percent (50%) of the outstanding shares or other
voting rights of the subject entity to elect directors. 

    1.2 "BLA" means a Biologics License Application, as defined in the U.S. Food, Drug and Cosmetic Act and the regulations
promulgated thereunder and any corresponding U.S. or foreign application, registration or certification. 

    1.3 "Change in Control" shall mean (i) the merger or consolidation of LICENSEE with another entity where less
than thirty percent (30%) of the outstanding voting securities of the combined entity immediately after such merger or consolidation is held by the holders of the outstanding voting securities of
LICENSEE immediately prior to such merger or consolidation; (ii) the acquisition by means of a stock purchase, directly or indirectly, by a party or parties acting in concert of fifty percent
(50%) or more of LICENSEE's voting stock in a single transaction or a series of related transactions; but excluding any transaction that is primarily for financing purposes or, (iii) the sale
of all or substantially all of the assets of LICENSEE. 

    1.4 "Confidential Information" shall mean (i) any proprietary or confidential information or material in tangible
form disclosed hereunder that is designated as "Confidential" at the time it is delivered to the receiving party, or (ii) proprietary or confidential information disclosed orally hereunder
which is identified as confidential or proprietary when disclosed and such disclosure of confidential information is confirmed in writing within thirty (30) days by the disclosing party. 

    1.5 "Field" means (i) production of recombinant proteins for the development, manufacture, use and sale of
products for human therapeutic uses, and (ii) for internal research purposes. For the purposes of this Agreement, "internal research purposes" shall mean any activity by SGI for its own
research and shall not include any right of transfer to a third party and shall not include any product which shall become a Licensed Product upon which royalties are due. 

1

 

    1.6 "IND" shall mean an Investigational New Drug application, as defined in the U.S. Food, Drug and Cosmetic Act and the
regulations promulgated thereunder for initiating clinical trials in the United States, or any corresponding foreign application, registration or certification. 

    1.7 "Licensed Product" shall mean any product in development by LICENSEE whose development, manufacture, use or sale
would constitute an infringement of a Valid Claim. in the country of development, manufacture, use or sale. 

    1.8 "Licensed Technology" means the Patent Rights. 

    1.9 "Net Sale" shall mean revenues on an accrual basis, in accordance with U.S. generally accepted accounting
principles, as follows: the invoice price of Licensed Products sold by LICENSEE its affiliates or its sublicensees to third parties, less to the extent included in such invoice price the total of:
(1) ordinary and customary trade discounts actually allowed; (2) credits, rebates and returns (including, but not limited to, wholesaler and retailer returns); (3) freight,
postage, insurance and duties paid for and separately identified on the invoice or other documentation maintained in the ordinary course of business, and (4) excise or value-added taxes, other
consumption taxes, customs duties and compulsory payments to governmental authorities actually paid and separately identified on the invoice or other documentation maintained in the ordinary course of
business. Net Sales shall also include the fair market value of all other consideration received by LICENSEE in respect of Licensed Products, whether such consideration is in cash, payment in kind,
exchange or another form. 

    1.10 "Patent Rights" shall mean the patent applications and patents listed on Exhibit A hereto and all divisions,
continuations, continuations-in-part, and substitutions thereof; all foreign patent applications corresponding to the preceding applications; and all U.S. and foreign patents
issuing on any of the preceding applications, including extensions, reissues, and reexaminations. 

    1.11 "Phase II" or "Phase III" shall mean a Phase II or, as the case may be, Phase III clinical trial as prescribed by
applicable FDA regulations, or corresponding regulations of any comparable entity. 

    1.12 "Valid Claim" means (i) a claim of an issued and unexpired patent included within the Patent Rights which
has not been held invalid in a final decision of a court of competent jurisdiction from which no appeal may be taken, and which has not been disclaimed or admitted to be invalid or unenforceable
through reissue or otherwise, or (ii) a claim of a pending patent application within the Patent Rights. 

 
 

ARTICLE 2—LICENSE    
  

    2.1.1  Grant of License.  ICOS hereby grants to LICENSEE and LICENSEE hereby accepts from ICOS, upon and
subject to the terms and conditions herein specified, a worldwide, non-exclusive, royalty-bearing license under the Patent Rights to make, to have made, to use and to sell Licensed
Products in the Field. LICENSEE shall have the right to sublicense its foregoing license rights to the Patent Rights for the purposes of developing, manufacturing, marketing or selling Licensed
Products, the development of which was commenced by LICENSEE (and not the sublicensee) prior to entering into such sublicense. The sublicense rights here granted are limited to sublicenses undertaken
for LICENSEE to engage in its own core business and are not granted nor shall be used to materially compete with ICOS licensing of the Patent Rights herein. LICENSEE shall not use the Patent Rights
outside the field. 

    2.1.2  Grant Back to Licensor.  In the event that LICENSEE modifies the [*]
described by the Patent Rights beyond "the use" expressly allowed and licensed herein to practice the Patent Rights within the Field, Licensee agrees to grant, and hereby does grant to ICOS, an
exclusive, worldwide, fully paid up license to any and all intellectual property and know-how arising out of the LICENSEE's use outside the permitted scope of the License granted in 2.1.1
above. 

2

 

    2.2  No Implied Rights.  Only the license granted pursuant to the express terms of this Agreement shall
be of any legal force or effect and no rights to transfer or, except as set forth in Section 2.1, sublicense the licensed rights are granted herein. No other license rights shall be granted or
created by implication, estoppel or otherwise. 

    2.3  Ownership: Enforcement.  At all times ICOS will retain ownership of the Licensed Technology and may
use, license and commercialize such Licensed Technology itself or with third parties. ICOS retains the right, at its sole discretion, to enforce, maintain and otherwise protect the Licensed
Technology. LICENSEE shall give ICOS immediate notice of any infringement by a third party of any of the Patent Rights which comes to LICENSEE'S attention during the term of this Agreement. LICENSEE
will cooperate with ICOS with respect to any actions ICOS may choose to take pursuant to this Subsection 2.3 and ICOS will reimburse LICENSEE for its reasonable costs and adjudicated claims against
SGI, all arising in this regard. 

    2.4  Delivery of Materials.  Within [*] ([*])
[*] after request by LICENSEE, ICOS shall deliver to LICENSEE the materials listed in Exhibit B. The materials shall be used in compliance with this Agreement and may
not be conveyed to other parties except for sublicensees as described herein. 

 
 

ARTICLE 3—CONSIDERATION    
  

    3.1  Milestone Payments.  Within thirty (30) days following the first achievement by LICENSEE, its
affiliates or its sublicensees of the following milestones with respect to each Licensed Product, LICENSEE shall pay to ICOS the applicable payments below: 

	3.1.1
	LICENSEE
shall pay to ICOS $[*] U.S. ([*] U.S. Dollars) upon approval to commence a
[*] or instead at ICOS discretion, a [*].

	3.1.2
	LICENSEE
shall pay to ICOS $[*] U.S. ([*] U.S. Dollars) upon [*].

	3.1.3
	LICENSEE
shall pay to ICOS $[*] U.S. ([*] U.S. Dollars) upon [*]. 

    3.2  Royalties.  LICENSEE shall pay to ICOS a royalty of [*]% on all Net Sales of
any Licensed Product (the "Royalty Rate") provided, however, that the Royalty Rate shall be [*]% for any Licensed Product
utilizing BR96. Notwithstanding the foregoing, in the event of a Change in Control of Licensee, the
Royalty Rate with respect to Licensed Products for which development is to commence after the consummation of the Change in Control shall be [*]% or the median royalty rate in
all other license agreements of ICOS then in effect under which ICOS has licensed any of the Patent Rights solely and is receiving royalties, but in no event shall the Royalty Rate be
[*]%. 

    3.3  One Royalty.  No more than one royalty payment shall be due with respect to a sale of a particular
Licensed Product. No multiple royalties shall be payable because any Licensed Product, or its manufacture, sale or use is covered by more than one Valid Claim. 

    3.4  Sublicensing Obligations.  Whenever LICENSEE sublicenses any rights hereunder it shall promptly
notify ICOS of the scope of the sublicense, the sublicensee' s name and address and the description of the Licensed Product to which the sublicense pertains. LICENSEE shall remain responsible for the
sublicensee's compliance with the terms of this Agreement and shall remain responsible for paying and reporting all royalties and milestone payments due hereunder as if the milestones and sales of
Licensed Products by sublicensee were those of LICENSEE, i.e., LICENSEE shall pay all royalties set forth in 3.2 with respect to Net Sales of Licensed Products by sublicensee, report all such sales
and pay the milestone payments set forth in Section 3.1 upon the achievement of the milestones by the sublicensee. 

3

 
 
 

ARTICLE 4—PAYMENTS; REPORTS AND RECORDS    
  

    4.1  Payments: Currency.  All payments due hereunder shall be paid by wire transfer in United States
dollars in immediately available funds to an account designated by ICOS. If any currency conversion shall be required in connection with the payment of any royalties hereunder, such conversion shall
be made by using the exchange rate for the purchase of U.S. dollars quoted in the U.S. version of the Wall Street Journal on the last business day of the calendar quarter to which such royalty
payments relate. 

    4.2  Royalty Reports and Payments.  After the first commercial sale of a Licensed Product on which
royalties are required to be paid hereunder, LICENSEE shall make quarterly written reports to ICOS within [*] ([*]) [*] after
the end of each calendar quarter, stating in each such report, by country, the number, description, and aggregate Net Sales of each Licensed Product sold during the calendar quarter, ICOS shall treat
all such reports as Confidential Information of LICENSEE. Concurrently with the making of such reports, LICENSEE shall pay ICOS the royalties specified in Section 3.3 hereof. 

    4.3  Records: Inspection.  LICENSEE shall keep complete, true and accurate books of account and records
for the purpose of determining the royalty amounts payable under this Agreement. Such books and records shall be kept at the principal place of business of LICENSEE for at least three (3) years
following the end of the calendar quarter to which they pertain and will be available for inspection during such period by a representative of ICOS for the purpose of verifying the royalty reports and
payments. Such inspections shall be made during ordinary business hours. The representative may be obliged to execute a reasonable confidentiality agreement prior to commencing any such inspection.
Inspections conducted under this Section 4.3 shall be at the expense of ICOS, unless an underpayment exceeding five percent (5%) of the amount stated for any period covered by the inspection is
identified, in which case all costs relating to the inspection will be paid immediately by LICENSEE. Any underpayments or unpaid amounts discovered by such inspections or otherwise will be paid
immediately by LICENSEE, with interest from the date (s) such amount (s) were due at the prime rate reported in the Wall Street Journal plus two percent (2%). 

 
 

ARTICLE 5—DILIGENCE    
  

    5.1  Reasonable Efforts.  LICENSEE agrees to use reasonable efforts consistent with its prudent business
judgment to diligently develop and commercialize the Patent Rights and obtain such approvals as may be necessary for the sale of the Licensed Products in the United States and such other worldwide
markets as LICENSEE elects to commercialize the Licensed Products. 

    5.2  Reports to ICOS.  During the term of this Agreement, for all products which are produced for
commercial manufacture using the Licensed Technology and for any modification of the transcriptional regulating sequences claimed by the Licensed Patent; LICENSEE shall keep ICOS reasonably informed
of its activities subject to this Agreement, including the achievement of the milestones set forth in Section 3.1 for the commercialization of each Licensed Product. "Reasonably informed" for
the purposes of this Section 5.2 shall mean at least once per calendar year and more often if the reported events will affect the duties of the LICENSEE under this Agreement. When the
registration package requesting approval for commercial sale of each Licensed Product is first filed in each of the U.S., Europe and Japan, and in each case when approval is received therefor,
LICENSEE will promptly notify ICOS. LICENSEE shall notify ICOS within [*] ([*]) [*] after the first commercial sale of each
Licensed Product. 

 
 

ARTICLE 6—CONFIDENTIALITY    
  

    6.1  Confidential Information.  Except as expressly provided herein, the parties agree that, for the term
of this Agreement and for five (5) years thereafter, the receiving party shall keep completely confidential and shall not publish or otherwise disclose and shall not use for any purpose except for the 

4

 

purposes contemplated by this Agreement any Confidential Information furnished to it by the disclosing party hereto, except that to the extent that it can be established by the receiving party by
written proof that such Confidential Information: 

	(a)
	was
already known to the receiving party, other than under an obligation of confidentiality, at the time of disclosure;

	(b)
	was
generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving party;

	(c)
	became
generally available to the public or otherwise part of the public domain after its disclosure and other than through any act or omission of the receiving party in breach of
this Agreement; or

	(d)
	was
subsequently lawfully disclosed to the receiving party by a person other than a party hereto. 

    6.2  Permitted Use and Disclosures.  Each party hereto may use or disclose information disclosed to it by
the other party to the extent such use or disclosure is reasonably necessary in complying with applicable law or governmental regulations or conducting clinical trials; provided that if a party is
required to make any such disclosure of another party's Confidential Information, other than pursuant to a confidentiality agreement, it will give reasonable advance notice to the latter party of such
disclosure and, will use its reasonable best efforts to secure confidential treatment of such information prior to its disclosure (whether through protective orders or otherwise). 

    6.3  Confidential Terms.  Except as expressly provided herein, each party agrees not to disclose any
terms of this Agreement to any third party without the consent of the other party; provided, disclosures may be made as required by securities or other applicable laws, or to actual or prospective
corporate partners, or to a party's accountants, attorneys and other professional advisors. 

    6.4  Agreement Announcement.  The parties hereby agree that fact of the consummation of this Agreement
and its general subject matter shall be deemed to be in the public domain and may be announced or otherwise referred to, subject to the prior approval of each party of the form of any such press
release or public announcement, but that the specific terms and conditions herein shall be Confidential Information of each party. 

 
 

ARTICLE 7—REPRESENTATIONS AND WARRANTIES    
  

    7.1  Representations and Warranties.  ICOS represents and warrants that at the time of entering into this
Agreement: (a) it is the sole and exclusive owner of all right, title and interest in the Patent Rights; and (b) it has the right to grant the license granted herein. 

    7.2  Disclaimer.  Nothing in this Agreement is or shall be construed as: 

	(a)
	A
warranty or representation by ICOS as to the validity or scope of any claim or patent within the Patent Rights;

	(b)
	A
warranty or representation that anything made, used, sold, or otherwise disposed of under any license granted in this Agreement is or will be free from infringement of any patent
rights or other intellectual property right of any third party;

	(c)
	An
obligation to bring or prosecute actions or suits against third parties for infringement of any of the Patent Rights or misappropriation of any Know-How; or

	(d)
	Granting
by implication, estoppel, or otherwise any licenses or rights under patents or other rights of ICOS or third parties, regardless of whether such patents or other rights
are dominant or subordinate to any patent within the Patent Rights. 

5

 

    7.3  No Warranties.  EXCEPT AS SET FORTH IN SECTION 7.1, ICOS GRANTS NO WARRANTIES WITH RESPECT TO THE
LICENSED TECHNOLOGY, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUE OR OTHERWISE, AND ICOS SPECIFICALLY DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR
A PARTICULAR PURPOSE, VALIDITY OF THE PATENT RIGHTS OR NON-INFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF ANY THIRD PARTY. 

 
 

ARTICLE 8—INDEMNIFICATION    
  

    8.1  By LICENSEE.  LICENSEE agrees to indemnify, defend and hold ICOS and its directors, officers,
employees and agents harmless from and against any and all liabilities, claims, demands, expenses (including, without limitation, attorneys and professional fees, other costs of litigation and
including the costs of establishing the right to indemnify), losses or causes of action (each, a "Liability") arising out of or relating in any way to (i) the possession, manufacture use, sale
or other disposition of Licensed Products, whether based on breach of warranty, negligence, product liability or otherwise, (ii) the exercise of any right granted to LICENSEE pursuant to this
Agreement, or (iii) any breach of this Agreement by LICENSEE, except to the extent, in each case, that such Liability is caused by the negligence (active, passive or imputed) or willful
misconduct of ICOS as determined by a court of competent jurisdiction. 

    8.2  By ICOS.  ICOS agrees to indemnify, defend and hold LICENSEE and its directors, officers, employees
and agents harmless from and against any and all liabilities, claims, demands, expenses (including, without limitation, attorneys and professional fees, other costs of litigation and including the
costs of establishing the right to indemnify), losses or causes of action (each, a "Liability") arising out of or relating in anyway to breach of any of ICOS's representations and warranties made
under Section 7.1 of this Agreement. 

 
 

ARTICLE 9—TERM AND TERMINATION    
  

    9.1  Term.  The term of this Agreement will commence on the Effective Date and remain in full force and
effect until the expiration of the last patent within the Patent Rights, unless earlier terminated in accordance with this Article 9. 

    9.2  Permissive Termination.  LICENSEE may terminate this Agreement at any time by providing ICOS notice
in writing at least thirty (30) days prior to the effective date of termination. 

    9.3  Termination for Cause.  Either party may terminate this Agreement in the event the other party has
materially breached or defaulted in the performance of any of its obligations hereunder, and such default has continued for thirty (30) days after written notice thereof was provided to the breaching
party by the non-breaching party. Any termination shall become effective at the end of such thirty (30) days period unless the breaching party has cured any such breach or default prior to
the expiration of such period. Notwithstanding the above, in the case of a failure to pay any amount due hereunder the period for cure of any such default following notice thereof shall be five (5)
days and, unless payment is made within such period, the termination shall become effective at the end of such period. 

    9.4  Termination for Insolvency.  If voluntary or involuntary proceedings by or against a, party are
instituted in bankruptcy under any insolvency law, or a receiver or custodian is appointed for such party, or proceedings are instituted by or against such party for corporate reorganization or the
dissolution of such party, which proceedings, if involuntary, shall not have been dismissed within sixty (60) days after the date of filing, or if such party makes an assignment for the benefit of
creditors, or substantially all of the assets of such party are seized or attached and not released within sixty (60) 

6

 

days thereafter, the other party may immediately terminate this Agreement effective upon notice of such termination. 

    9.5  Effect of Termination.  

	(a)
	Accrued Rights and Obligations.  Termination of this Agreement for any reason shall not release any party hereto from
any liability which, at the time of such termination, has already accrued to the other party or which is attributable to a period prior to such termination nor preclude either party from pursuing any
rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Agreement. It is understood and agreed that monetary damages may not be a sufficient remedy for any
breach of this Agreement and that the non-breaching party may be entitled to injunctive relief as a remedy for any such breach. Such remedy shall not be deemed to be the exclusive remedy
for any such breach of this Agreement, but shall be in addition to all other remedies available at law or in equity.

	(b)
	Return of Confidential Information.  Upon any termination of this Agreement, LICENSEE and ICOS shall promptly return
to the other party all Confidential Information, (except ICOS may retain copies of any reports or records subject to Article 4).

	(c)
	Stock on Hand.  In the event this Agreement is terminated for any reason, LICENSEE shall have the right to sell or
otherwise dispose of the stock of any Licensed Product then on hand until six (6) months after such termination, subject to Articles 3 and 4 and the other applicable terms of this Agreement.

	(d)
	Licenses.  All licenses granted hereunder shall terminate upon the termination of this Agreement. 

    9.6  Survival.  Articles 3, 4, 6, 7, 8 and Sections 9.5 and 9.6 and any Section of 10 that have continued
obligation of this Agreement shall survive the expiration or termination of this Agreement for any reason and any Definition of Section 1 required to interpret such surviving provisions. 

 
 

ARTICLE 10—MISCELLANEOUS PROVISIONS    
  

    10.1  Governing Law: Venue.  This Agreement and any dispute, including without limitation any
arbitration, arising from the performance or breach hereof shall be governed by and construed and enforced in accordance with the laws of the State of Washington and the United States of America,
without reference to conflicts of laws principles. The exclusive venue of any dispute arising out of or in connection with the performance or breach of this Agreement shall be the state or federal
courts in King County, Washington, and the parties hereby consent to the personal jurisdiction of such courts. 

    10.2  Assignment.  LICENSEE may not transfer or assign this Agreement or any of LICENSEE's rights
hereunder without the written consent of ICOS, except that LICENSEE may assign such rights or duties without such consent in connection with any merger,
consolidation, or any sale of all or substantially all of its assets. Any such attempted or constructive transfer or assignment other than the foregoing shall be void. ICOS may assign this Agreement
or its rights hereunder. This Agreement shall be binding upon and inure to the benefit of the parties and their permitted successors and assigns. 

    10.3  Waiver.  No waiver of any rights shall be effective unless expressly consented to in writing by the
party to be charged and the waiver of any breach of default shall not constitute a waiver of any other right hereunder or any subsequent breach or default. 

    10.4  Severability.  In the event that any provisions of this Agreement are determined to be invalid or
unenforceable by a court of competent jurisdiction, the remainder of the Agreement shall remain in full force and effect without said provision. 

7

 

    10.5  Notices.  All notices, requests and other communications hereunder shall be in writing and shall be
personally delivered or sent by telecopy or other electronic facsimile transmission or by registered or certified mail, return receipt requested, postage prepaid, in each case to the respective
address specified below, or such other address as may be specified in writing to the other parties hereto: 

	LICENSEE:	 	 
	 	 	Attn: H. Perry Fell, CEO

Company: Seattle Genetics, Inc.

Address: 22215 26th Avenue S.E. Suite 300

Bothell,WA 98021

Phone: 425-489-4990

Facsimile: 425-489-4798
	

ICOS:	
 	

 
	 	 	Legal Department

ICOS Corporation

22021 20th Avenue S.E.

Bothell, WA 98021

Phone: 425-485-1900

Facsimile: 425-398-8950

    10.6  Independent Contractors.  Both parties are independent contractors under
this Agreement. Nothing contained in this Agreement is intended nor is to be construed so as to constitute ICOS or LICENSEE as partners or joint venturers with respect to this Agreement. Neither party
shall have any express or implied right or authority to assume or create any obligations on behalf of or in the name of the other party or to bind the other party to any other contract, agreement, or
undertaking with any third party. 

    10.7  Compliance with Laws.  In exercising their rights under this license, the parties shall fully
comply in all material respects with the requirements of any and all applicable laws, regulations, rules and orders of any governmental body having jurisdiction over the exercise of rights under this
Agreement. LICENSEE shall be responsible, at its expense, for making any required registrations or filings with respect to this Agreement and obtaining any necessary governmental approvals with
respect hereto. 

    10.8  Use of Name.  Neither party shall use the name or trademarks of the other party for any purpose,
including, but not limited to, press releases without the prior written consent of such other party (except as set forth in Section 6.4 above). 

    10.9  Further Actions.  Each party agrees to execute, acknowledge and deliver such further instruments,
and do such other acts, as may be necessary and appropriate in order to carry out the purposes and intent of this Agreement. 

    10.10  Entire Agreement Amendment.  This Agreement constitutes the entire and exclusive Agreement between
the parties with respect to the subject matter hereof and supersedes and cancels all previous discussions, agreements, commitments and writings in respect thereof. No amendment or addition to this
Agreement shall be effective unless reduced to writing and executed by the authorized representatives of the parties. 

8

 

    IN WITNESS WHEREOF, ICOS and LICENSEE have executed this Agreement in duplicate originals by duly authorized officers. 

	ICOS CORPORATION	 	SEATTLE GENETICS, INC.
	

By:	
 	

/s/ GARY WILCOX
	
 	

By:	
 	

/s/ H. PERRY FELL

	

Name:	
 	

Gary Wilcox
	
 	

Name:	
 	

H. Perry Fell

	

Title:	
 	
EVP, Operations
	
 	

Title:	
 	
C.E.O.

	

Date:	
 	

10/16/00
	
 	

Date:	
 	

10/16/00

9

QuickLinks

CONTRACT MANUFACTURING AGREEMENT

APPENDIX E Price and Payment Terms

APPENDIX G NON-EXCLUSIVE LICENSE AGREEMENT

BACKGROUND

ARTICLE 1—DEFINITIONS

ARTICLE 2—LICENSE

ARTICLE 3—CONSIDERATION

ARTICLE 4—PAYMENTS; REPORTS AND RECORDS

ARTICLE 5—DILIGENCE

ARTICLE 6—CONFIDENTIALITY

ARTICLE 7—REPRESENTATIONS AND WARRANTIES

ARTICLE 8—INDEMNIFICATION

ARTICLE 9—TERM AND TERMINATION

ARTICLE 10—MISCELLANEOUS PROVISIONSPrepared by MERRILL CORPORATION www.edgaradvantage.com

QuickLinks
 -- Click here to rapidly navigate through this document

Exhibit 10.21  

  
 

    OFFICE LEASE    
  

DATED:
December 1, 2000. 

    This
Lease (this "Lease") is entered into by and between WCM 132-302, LLC a Washington limited liability company ("Landlord") and Seattle Genetics Inc., a Delaware
Corporation ("Tenant"). 

1.  FUNDAMENTAL LEASE PROVISIONS  

    1.1.  Building, Land and Project. Building means the 63,900 square feet Office Building at 21823
30th Avenue SE, Bothell, Washington 98021, which is located on the land described in Exhibit A (the "Land"). The Project means the Land, the Building and the other improvements
located thereon from time to time. 

    1.2.  Premises. The area marked on Exhibit B which includes all of the Building. The rentable area
of the Premises is estimated to be 63,900 rentable square feet. The final rentable area of the Premises will be determined by Landlord pursuant to Section 1.5 below. 

    1.3.  Term. 120 full calendar months, plus any partial month at the beginning of the Term. 

    1.3.1.  Renewal Option. Subject to the other terms of this Lease, Two (2) seven (7) year
options, See Rider I. 

    1.4.  Base Rent. Months referenced are through the applicable full calendar month. Any partial month at
the beginning of the lease term shall be calculated at the daily rate for the first full month. 

    Months
1 through 12 = $161,028.00 per month. 

    Plus,
on the first anniversary date of the Commencement Date and every annual anniversary date thereafter, the Base Rent shall increase by two percent (2%) of the prior year's Base
Rent. 

    1.5.  Tenant's Share of Common Expenses. 100%, based upon the estimated rentable square footage area of
the Premises compared to the rentable square footage area in the Building. If the Premises or Building is measured by Landlord and found to vary from the estimates, Landlord shall adjust the Base Rent
and Tenant's Share of Common Expenses accordingly. The area of the Premises and the Building shall be determined by Landlord applying the 1996 Standard Method of Measuring Floor Area in Office
Buildings as adopted by the Building Owners and Managers Association (ANSI/BOMA Z65.1 1996) consistently to all areas measured. 

    1.6.  Permitted Uses. General office, research, development, lifescience laboratory, small animal (i.e.
rats and mice and similar sized animals) vivarium, production uses and sale of materials, products and services used in Biotech/Biopharmaceutical and Lifesciences Industries and for no other purpose
without Landlord's prior written consent, which shall not be unreasonably withheld for uses meeting Landlord's then-existing use criteria for the Building and the Project. Tenant's current
projected uses include Biolevels II and III. If Tenant increases its uses above Biolevel III, Tenant shall so notify Landlord. 

    1.7.  Security Deposit. Initially $3,375,000, subsequently to be modified pursuant to  Section 4.3 and Exhibit F. 

    1.8.  Projected Commencement Date. June 1, 2001, subject to adjustment as provided in
Section 3. 

    1.9.  Brokers. (See Section 20.3) Landlord's Brokers: Mark Flippo and Scott Carter of Pacific Real
Estate Partners, Inc. Tenant's Broker(s): John Cox and Bill Neil of Kidder Mathews & Segner, Inc. 

 

    1.10.  Exhibits. The following exhibits and riders are a part of this Lease. 

	EXHIBIT A	 	Legal Description of Land
	EXHIBIT B	 	Floor Plan Showing Premises
	EXHIBIT C	 	Shell Definition and Description of Tenant Improvements
	EXHIBIT D	 	ERISA Disclosure
	EXHIBIT E-1	 	Signage
	EXHIBIT E-2	 	Desired Location for Directional Signage
	EXHIBIT F-1	 	Security Deposit Pledge Agreement
	EXHIBIT F-2	 	Account Control Agreement
	EXHIBIT F-3	 	Account Management Agreement
	EXHIBIT G	 	Rules and Regulations
	EXHIBIT H	 	Parking
	EXHIBIT I	 	Estimated Stabilized Triple Net Expenses
	EXHIBIT J	 	Right of First Offer
	EXHIBIT K	 	Restrictive Covenants
	EXHIBIT L	 	Generator Pad
	EXHIBIT M	 	Approved General Contractors
	EXHIBIT N	 	Janitorial Standards
	EXHIBIT O	 	Disclosed Hazardous Materials
	RIDER 1	 	Renewal Option

2.  PREMISES AND COMMON AREAS  

    2.1.  Premises. Landlord hereby leases the Premises to Tenant on the terms of this Lease, but reserving
to Landlord, the use of the exterior thereof, all space above the suspended ceiling, all space beneath the floor, and the right to install, maintain, use, repair, relocate and replace pipes, ducts,
conduits and wire leading through the Premises in locations which do not materially interfere with Tenant's use thereof. Tenant shall have access 24 hours per day, subject to temporary closures
for emergencies and repairs and similar matters outside Landlord's control. Landlord shall use reasonable efforts to minimize such closures. 

    2.2.  Common Areas. Landlord shall make available from time to time such "common areas" as Landlord deems
appropriate. As part of Common Expenses (as defined in Section 8.1), Landlord is responsible for operating and maintaining the common areas and Landlord may change the size, location, nature
and use of any common areas, provided that such change shall not materially adversely affect Tenant's access to or use of the Premises. Tenant has the nonexclusive right to use those common areas
which from time to time are designated for such use by Landlord, subject to any nondiscriminatory rules Landlord may reasonably impose. Landlord may close temporarily any common areas to make repairs
or changes or to prevent the acquisition of public rights in such areas, provided that Landlord shall use reasonable efforts to ensure that Tenant shall have access to the Premises at all times. In no
event shall the roof be considered part of the common areas. 

    2.3.  Parking. Tenant shall have the right to use the approximately 271 parking stalls in the parking
area shown on Exhibit H. Landlord shall take all reasonable measures necessary to insure that Tenant has access to such number of parking stalls. Tenant shall not be required to pay a fee for
use of the stalls for the initial term and any extensions of the Lease. Tenant shall be responsible for meeting any governmental car pool/van pool or other transportation obligations regarding its
employees, provided that Landlord shall provide, as a Common Expense, any signage, bike racks or similar physical improvements required by such transportation obligations. 

2

 

3.  LEASE COMMENCEMENT DATE  

    The Term shall commence (the "Commencement Date") on the first to occur of the following events (i) the date on which Tenant commences beneficial
occupancy of the Premises, or (ii) June 1, 2001 (as such date may be extended by Landlord Delay as defined in Exhibit C). Landlord shall deliver
possession to Tenant immediately following full execution of this Lease (provided that commencement of construction of Tenant Improvements shall be subject to the requirements of Exhibit C). If
the Commencement Date is later than the Projected Commencement Date in Section 1, this Lease shall not be void or voidable, nor shall Landlord be liable to Tenant for any loss or damage
resulting therefrom. The Term shall be for the number of months set forth in Section 1, plus the part of the month, if any, from the Commencement Date through the last day of the month in which
the Commencement Date occurs. After the Commencement Date has occurred, Landlord will prepare and Landlord and Tenant will execute an acknowledgement of the Commencement Date and related information. 

4.  RENT & SECURITY DEPOSIT  

    4.1.  Payment. Commencing on the Commencement Date, Tenant shall pay the Base Rent without setoff or
deduction, to Landlord's property manager, whose address is set forth in Section 20.9, on the first day of each month, in advance without notice or demand. The Base Rent for any partial
calendar month shall be prorated and the Base Rent for the first full calendar month shall be paid upon execution of this Lease. 

    4.2.  Additional Rent. All amounts other than Base Rent due by Tenant to Landlord under this Lease shall
be deemed "additional rent" and Landlord shall have all of the same remedies for Tenant's failure to pay additional rent as for failure to pay Base Rent. The term "rent" shall mean the combined Base
Rent and additional rent. 

    4.3.  Security Deposit. Within eleven (11) business days after the execution of this Lease, Tenant
shall execute and deliver to Landlord a Pledge Agreement in substantially the form attached hereto as Exhibit F-1, an Account Control Agreement in substantially the form attached
hereto as Exhibit F-2 and an Account Management Agreement in the form of Exhibit F-3 (or such other forms as are reasonably acceptable to the parties thereto)
granting Landlord a first position security interest in an account (the "Pledge Account") containing securities meeting the critical specified therein and/or cash in the total amount specified in
Section 1 as a Security Deposit as such amount may be reduced pursuant to the following paragraph. 

    Upon
written notice of its intention to do so after an Event of Default has occurred, Landlord shall be permitted to immediately direct the sale of bonds or other assets in the Pledge
Account and the disbursal of the proceeds thereof (not to exceed the amount required to cure the Event of Default) for application by Landlord on the same terms and conditions as Landlord would be
permitted to apply a cash security deposit. Landlord may apply all or part of the Security Deposit to any unpaid rent from Tenant or to cure any other defaults of Tenant. If Landlord uses any part of
the Security Deposit,
Tenant shall restore the Security Deposit or the Pledge Account to the amount required under the preceding paragraph as of the date of Landlord's application of the Security Deposit or any part
thereof, within 10 days after Landlord's written request. If Landlord transfers its interest in the Premises, Tenant shall cooperate with Landlord (at Landlord's expense) to assign the
Landlord's interest in the Pledge Account to its successor in interest, whereupon Landlord shall be automatically released from any liability for the return of the Security Deposit. If this Lease is
terminated prior to the end of the Initial Term or the Renewal Option Term (if exercised), any Rent paid for any period beyond the termination date will be considered an additional Security Deposit.
If, at the end of the Lease Term, Tenant has fully complied with all obligations under this Lease, then the remaining Security Deposit shall be returned to Tenant within thirty (30) days after
the final inspection of the Premises, after Landlord has verified that Tenant has fully vacated the Premises, removed all of its 

3

 

property and surrendered the Premises in the condition required by this Lease; provided that Landlord may hold back a portion of the Security Deposit until final determination of Tenant's share of
costs such as insurance and taxes, whereupon any final adjustment shall be made and any remaining Security Deposit shall be returned to Tenant. As with all other defaults, if the Premises are not
surrendered in the condition required, Landlord may perform the work necessary to put them in that condition and deduct the cost from the Security Deposit. Landlord's obligations with respect to the
Security Deposit are those of a secured creditor and not of a trustee. 

    The
amount of the Security Deposit and/or securities in the Pledge Account may be reduced through two mechanisms, provided that the total Security Deposit shall not in any
circumstances fall below Four Hundred Seventy Eight Thousand One Hundred Twenty-five Dollars ($478,125): 

    (a) If
Tenant engages in a public stock offering, and achieves and maintains a capitalized value of One Hundred Million Dollars ($100,000,000.00) there shall be a
reduction of the Security Deposit (a "Capitalized Value Reduction") to Nine Hundred Fifty Six Thousand Two Hundred Fifty ($956,250.00) (if for any reason the Security is already below that level,
there shall be no reduction), provided (i) if the capitalized value thereafter reduces below $100,000,000.00, the Capitalized Value Reduction shall be reversed and the amount of the Pledge
Account restored to the full amount required but for the Capitalized Value Reduction, and (ii) thereafter the Capitalized Value Reduction shall be reinstituted if Tenant reaches a capitalized
value of One Hundred Fifty Million Dollars ($150,000,000.00) and (iii) reversed again if the capitalized value thereafter reduces below $100,000,000 (and so on from that point with trigger
points of $100,000,000 and $150,000,000 respectively). 

    (b) In
addition to and independent of the Capitalized Value Reduction, the Security Deposit and/or bonds in the Pledge Account shall be reduced by Three Hundred Eighty
Four Thousand Seven Hundred Fifty Dollars ($384,790.00) per year commencing on the fourth anniversary of the Commencement Date Tenant if and only if Tenant has not at any time been in default after
notice and expiration of any applicable cure period under this Lease. 

5.  TENANT IMPROVEMENTS  

    Landlord shall deliver the Premises to Tenant upon full execution of this Lease with the Building Shell (as defined in Exhibit C) substantially
completed subject to punch list items as documented pursuant to Exhibit C. Tenant shall be responsible for installing its Tenant Improvements in the Premises in accordance with Exhibit C
including not beginning construction until its terms and conditions have been fully satisfied. Landlord represents that to the best of its knowledge the Building Shell meets and complies with all
applicable federal, state and local laws, ordinances and will be in good order, condition and repair upon delivery of the Premises to Tenant. Except for Building Shell punch list items and latent
Building Shell construction defects of which Tenant notifies Landlord within two (2) months after the date of this Lease (in which case Landlord shall correct such latent construction defects
at its expense), Tenant accepts the Project "as is where is" on the date of full execution of this Lease. If there exists any defect in the Project which is covered by an express or implied warranty
from any consultants, design professionals, engineers, contractors, subcontractors, manufacturer or suppliers, then Landlord shall diligently seek to enforce such warranties in accordance with their
terms for the benefit of the Landlord and Tenant. Notwithstanding the foregoing, Landlord assigns the benefit of all such warranties to Tenant and Tenant may enforce such warranties if Landlord fails
to do so after a notice from Tenant. 

6.  USE AND OPERATIONS  

    6.1.  Repairs and Maintenance of Premises. Subject to Landlord's obligations pursuant to Sections 7.5, 11
and 13, Tenant shall keep the Premises, including all equipment and fixtures located inside the Premises, clean and in good order, repair and condition. Tenant shall procure any licenses 

4

 

and permits required for Tenant's use. Tenant shall repair any damage to the Premises or Project caused by Tenant, its employees, agents or invitees. 

    6.2.  Signs. So long as Tenant occupies the Premises, Tenant shall have the right, at its cost, to have
prominent exterior building signage and monument signage at locations and size mutually acceptable to Landlord and Tenant, and to have its business name displayed on any reader board located in the
Building lobby and/or in any elevator lobby, and immediately outside the corridor door into the Premises, all in the Building standard size, typeface, materials and locations, which shall be
determined by Landlord. Landlord shall further cooperate with Tenant in seeking to obtain consent from any
applicable entity for reasonable directional signage within lot 41-A directing visitors how to locate the Premises, in the location to be mutually agreed by Landlord and Tenant. If
Landlord does not fund the construction of the monument sign on the northwest corner of Tract 41-C that has already been stubbed, such other signage on 41-A shall be at
Landlord's cost excluding any electrical service the Tenant may desire for the sign. Tenant shall not place or display any other sign, notice, picture, placard or poster, or any advertising material
whatsoever, visible, either directly or indirectly (as an outline or shadow on a glass pane), from anywhere outside the Premises without first obtaining Landlord's written consent, to be granted or
withheld in Landlord's discretion. Any consent by Landlord shall be upon the condition that Tenant will remove the advertising promptly on Landlord's request, and in any event, at the expiration or
sooner termination of this Lease, and Tenant shall repair any damage to the Premises or the Project caused thereby. Any exterior signage agreed to by Landlord shall be further subject to the terms and
conditions found in Exhibit E. 

    6.3.  Rules and Regulations. Within a reasonable period of time after receipt of a written copy thereof,
Tenant shall comply with any nondiscriminatory Rules and Regulations established by Landlord regarding the Project (the "Rules and Regulations"), provided that in the event of a direct and
irreconcilable conflict between the terms of this Lease and the Rules and Regulations, the terms of this Lease shall control. All Rules and Regulations shall be reasonable and shall not interfere with
Tenant's conduct of its business so long as such conduct is otherwise in compliance with the Lease. The current Rules and Regulations are attached as Exhibit G. 

    6.4  Landlord's Right of Access. Tenant shall give Landlord and its agents access to the Premises at all
reasonable times with reasonable prior notice, and immediately in an emergency, to enable them to inspect and examine the Premises and to make repairs, additions and alterations to the Premises or the
Building, and to show the Premises to brokers and prospective purchasers. Within 12 months of the scheduled termination date of this Lease or at any time Tenant is in default the Landlord may
also, with reasonable prior notice show the Premises to prospective tenants. Landlord shall use commercially reasonable means to allow an employee of Tenant to accompany Landlord in any entry and to
limit any disruption to Tenant resulting from such entry, but there shall be no reduction of rent and no liability on the part of Landlord due to such access or activities, provided that this release
shall not apply to physical damage to persons or property (excluding consequential damages such as lost profits) to the extent caused by Landlord's gross negligence or willful misconduct. Landlord
shall also coordinate with Tenant regarding procedures for entry into any areas restricted because of biological or chemical hazard or contamination risk, and understands that except for an emergency,
such entry shall be made only when accompanied by an employee of Tenant. 

    6.5.  Liens. At its expense, Tenant shall cause to be fully and completely discharged of record or fully
bonded against, within 10 days of Landlord's demand, any labor or materialman's lien claim or other lien or claim filed against the Premises or the Project for work claimed to have been done
for, or materials claimed to have been furnished to, or on behalf of, Tenant. 

    6.6.  Comply With Laws. At its expense, Tenant shall comply with all laws, orders, ordinances and
regulations of federal, state, or other governmental authorities and with any direction made pursuant to law of any public officer or officers, with respect to the Premises or the use thereof,
including any obligation to make alterations in the Premises required as a condition of Tenant's continuing use. 

5

 

    6.7.  Not Invalidate Insurance. Tenant shall not do or permit to be done any act or thing upon the
Project which will invalidate or be in conflict with the certificate of occupancy for the Building (once issued), or the terms of any insurance policies covering the Project or increase the premium
for insurance upon the Project. Landlord agrees that Tenant shall not be deemed to be in default under this Section 6.7 so long as its uses are those same actual uses as it engages in at the
commencement of this Lease (i.e. before changing those uses, even within the general description of "Permitted Uses". Tenant shall confirm that any altered uses in the future comply with this
Section 6.7. If there is a conflict with Landlord's insurance, and so long as Tenant is the full building lessee (and therefore fully responsible for any increased cost), Landlord shall use
commercially reasonable efforts to find a reasonably acceptable alternate insurer or policy in which such conflict does not exist. 

    6.8.  Insurance. At its expense, Tenant shall obtain and carry at all times during the term of this
Lease: (i) commercial general liability insurance covering the Premises with a combined single limit of at least $5,000,000, or such higher amounts as Landlord may from time to time reasonably
designate on not less than 30 days notice to Tenant, consistent with insurance levels required by prudent landlords for similar projects and uses in the area, containing a contractual liability
endorsement covering the matters in Section 12; and (ii) fire and extended coverage insurance for Tenant's property to its full replacement value. Such policies shall be written by
insurers reasonably acceptable to Landlord and shall not contain deductible amounts in excess of $10,000 without Landlord's prior written consent, and shall be primary and non-contributory
with any insurance carried by Landlord. The liability policy shall name Landlord, its mortgagees, the members of Landlord, Landlord's property manager and Barnes & Nelson Union Partners, LLC,
as additional insureds, as their interests may appear. All such insurers shall agree not to cancel or amend (including as to scope or amount of coverage) such policies without at least 30 days
prior written notice to Landlord. Tenant shall furnish Landlord with certificates of insurance evidencing the above coverage at all times during the term of this Lease; with new certificates delivered
to Landlord at least 20 days prior to expiration of the coverage shown by the prior certificates. 

    If
Tenant manufactures on the Premises consumer goods using any materials supplied by Landlord (including but not limited to power or water supplied as part of utilities to the
Premises), Tenant's insurance shall include products liability insurance in the amounts specified for the commercial general liability insurance. 

    6.9  Landlord's Insurance. As part of Common Expenses, Landlord shall maintain (a) policies of
commercial property insurance ("special cause of loss" with replacement cost endorsement) covering loss of or damage to the Project, including all permanent improvements and alterations that will
become Landlord's property even if installed by Tenant, which insurance shall include flood and earthquake coverage; (b) commercial general liability insurance in an amount and with coverage
determined by Landlord insuring Landlord against liability arising out of ownership, operation, use or occupancy of the Project; and (c) a rental income insurance policy, with loss payable to
Landlord, in an amount equal to one year's Base Rent, plus the estimate of Tenant's Share of Common Expenses Real Property Taxes and insurance premiums. The policy obtained by Landlord shall not be
contributory and shall not provide primary insurance. Landlord shall not obtain insurance for Tenant's fixtures or equipment or Building improvements installed by Tenant in the Premises. Tenant
acknowledges that Landlord's insurance, through primary policies, special coverages or umbrella policies, may at Landlord's option be such as to include coverage for Hazardous Materials contamination
and the liabilities flowing therefrom, provided that the cost of specific Hazardous Materials coverage shall be approximately $3,000 per year (adjusted over time consistent with general increases in
environmental insurance costs and to reflect any risk experience of Tenant in particular), with a deductible of no less than $50,000 and on which Tenant shall be named as an additional insured. In the
event of use of umbrella policies, the cost of environmental insurance shall be reasonably allocated by Landlord based on the experience/risk of the various properties if such matters are taken into
account by the carrier in setting premiums. Common Expenses shall include any commercially reasonable deductible amount 

6

 
under insurance policies maintained pursuant to this Section 6.9, other than Landlord's liability insurance policy. Tenant shall not do or permit anything to be done which invalidates any such
insurance policies or increases the cost thereof (unless Tenant pays the cost of such increase). 

    6.10.  Surrender. On or before the expiration or termination of this Lease, Tenant shall remove from the
Premises: (i) all of its personal property, including any equipment and signage; and (ii) any improvements or alterations installed by Tenant which Landlord directs Tenant to remove
(excepting the Initial Improvements). At the time of requesting Landlord's consent to an improvement or alteration, Tenant may request in writing that Landlord elect whether to require Tenant to
remove such improvement or alteration upon expiration or termination of this Lease, and Landlord shall make such election at the time of granting consent (or within 30 days after Tenant's
request if the improvement or alteration does not require Landlord's consent). If Landlord fails to make such election, Landlord shall be deemed to have elected to have Tenant remove the improvement
or alteration. 

    With
respect to the Initial Improvements, by notice given not later than six (6) months prior to the expiration of the initial term of this Lease, Landlord may require Tenant
to demolish the interior improvements to any laboratory space, returning such space to a clean, capped and in good order Building Shell condition, and Tenant shall do so prior to expiration of the
Lease, provided that Tenant's total monetary obligation for its out-of-pocket costs of such demolition and return to shell condition shall not exceed $300,000 (and if such
amount is not sufficient to adequately perform the task, Tenant shall consult with Landlord and shall use such funds to perform such portions of the demolition task as Landlord directs). This
demolition and return to shell condition obligation shall not apply if Tenant exercises its Renewal Option. If this Lease is terminated during its initial term for any reason other than Landlord's
default, then this requirement shall apply, provided that if this Lease is terminated due to Tenant's default, Landlord may elect to simply collect the $300,000 obligation in lieu of allowing Tenant
to conduct such demolition and return to shell. If Tenant conducts the demolition and return to shell condition as provided above, Tenant shall be entitled to retain all items removed from the
laboratory area of the Premises in the course of such work. 

    In
addition, on or before the expiration or termination of this Lease, Tenant shall: (i) repair any damage to the Premises caused by Tenant, including any damage caused by
Tenant's removal of personal property, improvements or alterations, and (ii) surrender the Premises in good order and condition, broom clean, subject to reasonable wear and tear. If Tenant
fails to remove any personal property, Landlord may either have it removed and stored in a public warehouse at the risk of Tenant (the expense of such removal, storage and repairs necessitated by such
removal shall be paid by Tenant) or deem them abandoned whereupon they shall become the property of Landlord without payment or offset therefore. 

    6.11.  Americans with Disabilities Act. Tenant shall be responsible for compliance with the Americans
with Disabilities Act (the "ADA") with regard to Tenant's operations in the Premises, and any alterations to the Premises after the Commencement Date. Landlord, as part of Common Expenses, shall be
responsible for the ADA with regard to the common areas and with regard to the initial design and construction of the building shell (provided that if the Building Shell was in violation of the ADA as
of the date of full execution of this Lease, then the cost of correcting that violation shall be Landlord's expense). Tenant, based on its position as manager of the construction of the Tenant
Improvements, shall be responsible for their compliance with ADA. 

    6.12.  Compliance with CC&Rs. Tenant shall not violate any covenants, conditions or restrictions
("CC&R's") or other agreements encumbering the Project the current versions of which have been provided to Tenant in writing prior to the execution of this Lease and are listed on Exhibit K.
Landlord agrees not to voluntarily agree to any modifications of such CC&Rs that would prevent Tenant from engaging in the Permitted Uses set forth in Section 1.6. 

7

 

7.  UTILITIES, SERVICES AND MAINTENANCE  

    7.1.  Utilities. Tenant shall promptly pay for utilities and related services provided to the Premises
during the Term, including but not limited to, gas, garbage, water, electricity, telephone, and sewer charges, including repair, replacement, hook-up and installation charges. If any of
these utilities or services are not separately metered or billed, Landlord shall equitably allocate the cost among the users and Tenant shall pay its share of the cost within 30 days after
receipt of Landlord's invoice. Alternately, Landlord may elect to include these types of costs in the Common Expenses. 

    7.2.  Basic Services. Landlord shall provide toilet room supplies, window washing at reasonable
intervals, and customary janitorial service for the common areas. Janitorial service shall be provided five days per week excluding service for legal holidays, provided that Tenant may elect to
provide its own janitorial service to the Premises, in which case Tenant shall meet or exceed Landlord's general janitorial standards for the Project as shown on Exhibit N. In the event Tenant
does elect to provide its own janitorial service, Landlord shall have the right, upon reasonable notice to Tenant, to inspect the Premises to review compliance with the janitorial standards. The costs
of any janitorial or other services provided by Landlord to Tenant shall be reimbursed by Tenant as additional rent within twenty (20) days after receipt of billings therefore. 

    From
7:00 a.m. to 6:00 p.m. on weekdays and from 8:00 a.m. to 1:00 p.m. on Saturdays excluding legal holidays ("Normal Business Hours"), Landlord shall
furnish to the Premises the heating and air conditioning required in Landlord's reasonable judgment for the comfortable use and occupancy of the Premises. If requested by Tenant, Landlord shall
furnish heating and air conditioning at times other than Normal Business Hours. The charge for after-hours HVAC service is $30.00 per hour, subject to periodic increase by Landlord, and shall be paid
by Tenant as additional rent within twenty (20) days after receipt of billings therefore (or, if such services are regularly scheduled, Landlord may require monthly payments simultaneous with
Base Rent and Additional Rent). To the extent the utilities for after-hours services are separately metered and charged directly to Tenant, Tenant shall pay such charges directly to the applicable
utility. 

    Landlord
shall furnish the Premises with electricity for normal office use, including lighting and operation of customary office machines, and water, both in quantities usually
furnished or supplied by Landlord to tenants leasing space in the Building. The mechanical system is designed to accommodate normal and customary heating loads. Before installing lights and laboratory
equipment in the Premises, which in the aggregate exceed the design of the systems, Tenant shall obtain the written permission of Landlord which shall not be unreasonably withheld if Tenant installs
at its expense any necessary equipment (including additional HVAC) to service such excess demand. Landlord may refuse to grant such permission unless Tenant agrees to pay in advance Landlord's costs
of installing separate metering and any supplementary air conditioning or electrical systems required by such equipment or lights. In addition, Tenant shall pay Landlord in advance, as additional rent
(except to the extent the costs are billed directly to Tenant through separate metering), on the first day of each month during the Term, the Landlord's estimate of the cost of furnishing electricity
for the operation of such equipment or lights and Landlord's estimate of the cost of operating and maintaining supplementary air conditioning units necessitated by Tenant's use of such equipment or
lights. Landlord shall be entitled to install and operate, at Tenant's cost, a monitoring/metering system in the Premises to measure the added demands on electricity and the HVAC systems resulting
from such equipment and lights. Tenant shall comply with Landlord's instruction for the use of drapes, blinds and thermostats. 

    Landlord
shall provide such security for the Project as it deems appropriate. During other than Normal Business Hours, Landlord may restrict access to the Building in accordance with
the Building's security system, provided that Landlord shall not restrict Tenant's ability to have access, through card readers or otherwise, 24 hours per day, 365 days per year.
Landlord shall not be liable to Tenant for injury to its agents, employees, customers or invitees, or for losses due to theft or burglary, or for 

8

 

damages done by unauthorized persons, provided that this release shall not apply to physical damage to persons or property (excluding consequential damages such as lost profits) to the extent caused
by Landlord's gross negligence or willful misconduct. Tenant may install or institute, subject to the provisions of Section 10, such additional security measures as it deems necessary or
appropriate to protect Tenant's business and property provided that Tenant shall permit Landlord access as described in Section 6.4 above. 

    Landlord
shall provide two card keys to the Building and two keys for the corridor door entering the Premises, and additional keys at a charge by Landlord on an order signed by
Tenant. All such keys shall remain the property of Landlord. No additional locks shall be allowed on any door of the Premises without Landlord's written permission, which shall not be unreasonably
withheld. Landlord shall be provided keys to any additional door locks added by Tenant. Upon termination of this Lease, Tenant shall surrender to Landlord all keys and card keys to the Premises. 

    7.3.  Additional Services. If Tenant desires any of the aforementioned services (or items) in amounts in
excess of Building standard (other than HVAC service) Landlord will provide those additional services if it is reasonably practical to do so and, Tenant shall be directly billed and shall pay to
Landlord as additional rent hereunder, the cost of providing such additional services (or items), within twenty (20) days after receipt of billings therefore (or, if regularly scheduled,
simultaneously with Base Rent and Additional Rent). 

    7.4.  Interruption of Service. Landlord does not warrant that any utilities or services will be free from
interruption including by reason of accident, repairs, alterations or improvements and including by reason of computer design or programming weaknesses or date sensitive microprocessors. Tenant is
encouraged to formulate a contingency plan to cover operation of their business in the event of a power failure. No interruption shall be deemed an eviction or disturbance of Tenant, or render
Landlord liable to Tenant for damages, or relieve Tenant from the full and complete performance of all of Tenant's obligations under this Lease, provided only that to the extent casualty damage
renders the Premises untenantable, and loss of rents arising therefrom are covered by rental interruption insurance carried by Landlord, then, and to that extent, rental on the Premises shall abate in
the proportion that the portion of the Premises rendered untenantable bears to the total Premises. 

    7.5.  Repair and Maintenance of the Building. Landlord shall be responsible for maintenance and repairs
to the exterior and structural portions of the Building as well as all building systems up to point of connection with the Premises and the repairs and maintenance to the common areas (the "Project
Work"). Landlord agrees to maintain its portion of the Project in a manner consistent with a high quality building within the Highlands Campus area. Project Work shall include the repair, maintenance
and replacement of the roof and roof membrane, electrical, plumbing and other mechanical systems and the exterior of the Building. The cost of the Project Work shall be included in Common Expenses
pursuant to Section 8.1 (subject to the limitations contained therein). Notwithstanding the foregoing, if any of the Project Work is necessitated due to damage caused by Tenant, its agents,
employees, or invitees, Landlord may require Tenant to pay the cost of that work within 10 days of receipt by Tenant of the invoice. 

    7.6  Tenant-Provided Services. So long as Tenant is the full building tenant, Landlord agrees to
reasonably consider requests by Tenant for Tenant to provide directly services that are otherwise to be provided by
Landlord under this Lease, and any such services shall be provided pursuant to commercially reasonable standards mutually agreed by Landlord and Tenant, and shall be paid directly by Tenant. 

9

 

8.  COMMON EXPENSES  

    8.1.  Definitions. The following terms shall have the following meanings: 

    Common Expenses. Common Expenses shall mean all costs incurred by Landlord in connection with the operation, repair and maintenance of
the Project including payroll costs, insurance, property management of $26,838.00 per year with a 2% annual increase, utilities, Real Property Taxes, Project Work, and any other expenses which in
accordance with generally accepted accounting and management practices would be considered an expense of maintaining, managing, operating, owning, or repairing the Project. Common Expenses shall
exclude (i) initial leasing costs including legal fees, advertising and marketing expenses and tenant improvements and leasing commissions for other tenants; (ii) costs of any special
services rendered to individual tenants for which a special charge is collected; (iii) capital improvements except (a) capital repair and replacement of improvements or systems existing
as of the Commencement Date of this Lease (provided that Tenant shall not be charged for the amortization of any such capital repair and replacement of roof membrance or elevator during the Initial
Term of this Lease), (b) capital improvements required by law or regulation as adopted or reinterpreted after the Commencement Date of this Lease, and (c) capital improvements that
Landlord estimates will reduce Common Expenses in an amount equal to or greater than the amortization of the improvement (and provided that all capital improvements shall be amortized over their
useful life with interest at 13% per annum); (iv) legal expenses in enforcing leases; (v) interest or amortization payments on any mortgage or ground lease of the Project or the
underlying property or any other expense incurred in connection with such financing; (vi) costs incurred in connection with the initial construction or design of the Building or to repair,
change, improve, replace or correct defects in the original construction or design of the Building, ordinary wear and tear excepted; (vii) costs incurred because of Landlord's breach of any
legal obligation (including any obligation of Landlord under any lease of space in the Building), or the breach of any legal obligation by any other tenant in the Building; (viii) amounts paid
to persons or entities related to Landlord in excess of the reasonable cost thereof had such services been provided by unrelated parties; (ix) costs of curing any violation of any environmental
law or regulation applicable to the building where the violation existed as of the Commencement Date (except if caused by Tenant prior to such date) or is due to the negligence of Landlord, its agents
or employees; (x) costs, fines or penalties incurred due to violation by Landlord of any applicable law; (xi) costs of acquisition of sculpture, paintings, or other objects of art
installed in, on or above the building; (xii) wages, salaries or other compensation or costs incurred with respect to (A) any managerial or executive employees or agents of Landlord
above the position of Project Manager for the purpose of managing Landlord's interest in the building or (B) any persons employed
in commercial concessions operated by Landlord; (xiii) costs of traveling to and attending any off-site management meetings or meetings of professional property management for
promotional associations or groups; or (xxii) depreciation of or reserves for replacement of any of Landlord's assets or rental or other expenses incurred in leasing air conditioning systems,
elevators or similar items except in an amount that Landlord estimates is reasonably equivalent to the amount that would be charged as amortization had such items been purchased and capitalized. 

    Real Property Taxes. Real Property Taxes shall mean all taxes, governmental charges and assessments levied on the Project, or any
improvements, fixtures and equipment and all other property of Landlord, real or personal, used in the operation of the Project; any taxes in addition to or in lieu of, in whole or in part, such
taxes; any tax upon leasing or rents of the Building (excluding B&O tax); any other governmental charge such as payments for transit, carpooling or environmental facilities; and all costs and expenses
incurred by Landlord in connection with the attempt to reduce any of the foregoing, whether by negotiation or contest. Real Property Taxes shall include ULID, CRID and other assessments in effect on
the Commencement Date and subsequently arising. Real Property Taxes shall not include any franchise or state income tax, inheritance tax, estate tax, real estate transfer excess tax, or other similar
tax, or any impact fees, or other charges payable in connection with the development of the Project including but not limited to traffic mitigation payments. 

10

       8.2.  Additional Rent for Common Expenses. Commencing on the Commencement Date, in addition to all other
amounts due hereunder and as additional rent, Tenant shall pay Landlord each year Tenant's Percentage times the total Common Expenses for that year ("Tenant's Share of Common Expenses"), such payments
to be made in accordance with Section 8.3. The amount payable shall be prorated for any partial year in the Lease Term. 

    8.3.  Estimated Payments. Landlord currently accounts for Common Expenses on an
April 1—March 31 fiscal year. Each year, Landlord shall give Tenant written notice of the estimated amount payable by Tenant under this Section for the ensuing fiscal year,
which estimate Landlord shall endeavor to provide by March 1 of each year. On or before the first day of each month thereafter, Tenant shall pay Landlord 1/12th of such estimated amounts,
provided Landlord may, by written notice to Tenant, revise its estimate whereupon subsequent payments by Tenant for the remainder of the year shall be based upon such revised estimate. If the notice
of the annual estimate is given after commencement of the applicable year, then Tenant's first payment of the new monthly amount shall be accompanied by payment of the difference between the new
estimate and all estimated payments previously made by Tenant for that year. After the close of each fiscal year during the term of this Lease, Landlord shall deliver to Tenant a statement setting
forth the total amount of Tenant's Share of Common Expenses for such year, whereupon there shall be a final adjustment between Landlord and Tenant in connection with amounts due Landlord under this
Section and Tenant shall pay Landlord any amount due Landlord within 30 days of receipt of such statement, and any amount due Tenant shall be credited to the next accruing amounts due Landlord
pursuant to this Section or if the Lease has terminated or expired, such amount shall be credited against any amounts still due Landlord and the balance shall be refunded to Tenant. Landlord shall use
reasonable efforts to provide such statement by June 30 of each year following the relevant expense year. Landlord shall not be entitled to revise its final determination of Common Expenses at
any time after the one-year anniversary of such June 30 deadline. 

    8.4.  Occupancy Adjustment. If less than an average of 95% of the rentable area of the Building is
occupied by tenants during all or any portion of a year, Landlord shall make an appropriate adjustment of Common Expenses for such year employing sound accounting and management principles, to
determine the amount of Common Expenses that vary with occupancy and that would have been incurred if 95% of the rentable area of the Building had been occupied during the entire year, with the intent
that Tenant's Percentage times the Common Expenses so calculated better reflect Tenant's actual consumption of Common Expenses. In no event shall Landlord be entitled to receive reimbursement from all
tenants for more than its actual out-of-pocket expenses. 

    8.5.  Personal Property Taxes. Tenant shall pay, prior to delinquency, all personal property taxes on
Tenant's property. 

9.  HAZARDOUS MATERIALS  

    9.1.  Hazardous Materials. 

    9.1.1  Tenant and Tenant's officers, contractors, subcontractors, licensees, agents, servants,
employees, guests, invitees or visitors, or any assignee or sublessee or other person for whom Tenant would otherwise be liable (individually, a "Tenant Party" and collectively, "Tenant Parties")
shall comply with all Environmental Laws (as defined below) in connection with Tenant's or Tenant Parties use, production, storage or disposal of any Hazardous Materials (as defined below) on, under
or about the Premises. Tenant hereby represents, warrants, covenants and agrees that all operations or activities upon, or any use or occupancy of the Premises, or any portion thereof, by Tenant or
any Tenant Party of the Premises or any portion thereof, shall be in all material respects in compliance with all state, federal and local laws and regulations governing or in any way relating to the
generation, handling, manufacturing, treatment, storage, use, transportation, spillage, 

11

 

leakage, dumping, discharge or disposal (whether legal or illegal, accidental or intentional) of any Hazardous Materials. Neither Tenant nor any Tenant Party shall use or dispose of any Hazardous
Materials in or on the Premises, the Building, the Project, or any adjacent property, or in any improvements thereto, except for such Hazardous Materials as are essential to the operation of Tenant's
and Tenant Parties' business and reported to Landlord not less often than annually pursuant to Exhibit O, and then only in accordance with all applicable laws and regulation. Tenant shall, and
shall ensure that all Tenant Parties shall, at all times comply with Environmental Laws and best industry standard research, medical and safety practices in connection with the use, handling,
production storage or disposal of any Hazardous Material, including, but not limited, to any Medical Products (as defined below), at Tenant's sole expense. 

    9.1.2  As used herein, the term "Hazardous Materials" means any chemical, compound, substance, material,
controlled substance, object, condition, waste, living organism or part thereof (including genetic materials), virus or combination or modification thereof which is or may be hazardous to human health
or safety or to the environment (whether potentially injurious to persons and property and whether potentially injurious by themselves or in combination with other materials) due to its radioactivity,
ignitability, corrosivity, reactivity, explosivity, toxicity, carcinogenicity, mutagenicity, phytotoxicity, infectiousness or other harmful or potentially harmful properties or effects, including,
without limitation, petroleum and petroleum products, asbestos, radon, polychlorinated biphenyls (PCBs) and all of those chemicals, substances, materials, controlled substances, objects, conditions,
wastes, living organisms or combinations thereof which are now or become in the future listed in the
United States Department of Transportation Hazardous Materials Table [49 C.F.R. § 172.101], as amended from time to time, or listed, defined or regulated in any
manner by any Environmental Law. 

    9.1.3  As used herein, the term "Environmental Laws" means any and all federal, state or local
environmental, health and/or safety-related laws, regulations, standards, decisions of courts, ordinances, rules, codes, orders, decrees, directives, guidelines, permits or permit conditions,
currently existing and as amended, enacted, issued or adopted in the future relating to the environment or to any Hazardous Material (including, without limitation, the Comprehensive Environmental
Response, Compensation and Liability Act of 1980 (42 U.S.C. § 9601, et seq.), the Washington Model Toxics Control Act (Ch. 70.105D RCW) and the Washington Hazardous Waste Management Act
(Ch. 70.105 RCW) which are or become applicable to Tenant or the Premises. 

    9.1.4  As used herein, the term "Medical Products" means all regulated substances, chemicals, compounds,
drugs, blood, tissue, organs, serums, organisms or part thereof (including genetic materials), viruses, waste and other materials related thereto and used in connection with medical treatment,
laboratory analysis, production or analysis of drugs, or other biomedical research. 

    9.1.5  As used herein, the term "Environmental Condition" means any release or spill of any Hazardous
Materials into the environment, including surface water, groundwater, drinking water supply, sewer or storm water drain, land, soil, surface or subsurface strata or the ambient air, where such release
or spill is potentially in violation of Environmental Laws or is required to be reported to the Washington State Department of Ecology or other appropriate governmental authority. 

    9.1.6  Tenant and Tenant Parties shall design and construct their Tenant Improvements, including any
upgraded HVAC and plumbing systems, using best available commonly used industry technique designed to ensure that Tenant's and Tenant Parties' Hazardous Materials do not compromise the air quality
outside the Premises or in any space occupied by other tenants (including Tenant's subtenants) or allow the possibility of water system back-up into the Building or otherwise migrate to
any adjacent space occupied by any other tenant. In particular, Tenant shall use, and shall require Tenant Parties' best available commonly used industry techniques to 

12

 

prevent air mixing from areas of potential contamination into other areas of the Building. Tenant shall indemnify and hold Landlord harmless from and against any and all losses, expenses, liabilities,
penalties or costs arising directly or indirectly from Tenant's or Tenant Parties' failure to isolate building systems or to cause an Environmental Condition in areas of the Project outside the
Premises as a result of its design or construction of the Tenant Improvements. 

    9.1.6  Tenant shall deliver (or cause Tenant Parties to deliver) to Landlord (a) within
60 days after Lease execution or prior to Tenant's first draw request for the Allowance pursuant to Exhibit C and (b) on request once each year during the Term, a list specifying
the type and quantity of all Hazardous Materials used or stored by Tenant or Tenant Parties on the Premises (and attached hereto as Exhibit O, as amended from time to time) together with copies
of all permits, licenses and approvals required in connection with the use or storage of such materials, together with, on request, Tenant's and Tenant Parties' Hazardous Materials data safety sheets
and any other documentation with respect to Tenant's and Tenant Parties' usage, storage, and disposal of Hazardous Materials that are required by the City of Bothell Fire Department. Notwithstanding
the foregoing, Tenant shall respond, and shall cause Tenant Parties to respond to any written request by Landlord for confirmation whether there has been a significant increase, as evaluated in
Tenant's reasonable judgment, in the quantity of Hazardous Materials or change in the type of Hazardous Materials utilized by Tenant or Tenant Parties, provided that such request shall not be made
more than once per calendar quarter. To the extent reasonably requested by Landlord, Tenant will provide additional documents or information with respect to its and Tenant Parties' Hazardous Materials
within a reasonable period of time after receipt of a specific written request. Tenant shall promptly notify Landlord in writing of (i) any notices of violation or potential or alleged
violation of any Environmental Law which are received by Tenant from any governmental agency or any Tenant Party; (ii) any and all inquiry, investigation, enforcement, clean-up,
removal or other governmental or regulatory actions instituted or threatened relating to the Premises; and (iii) all claims made or threatened by any third-party against Tenant or a Tenant
Party or the Premises relating to any Hazardous Materials used by Tenant or a Tenant Party at the Premises. If any Environmental Condition occurs that is or may be a result of Tenant's or any Tenant
Party's actions during the Initial or Extended Term, or if Tenant or any Tenant Party has disposed of or caused a release of Hazardous Materials at, on or about the Project other than in accordance
with Environmental Laws, Tenant shall promptly prepare or cause the Tenant Party to prepare a remediation plan for Landlord's review and approval, which shall not be unreasonably withheld,  provided, however, that Landlord shall not require any remediation in excess of or to higher standards than would be mandated by applicable
Environmental Laws. Tenant's obligation to remediate any Environmental Condition shall not be contingent on an enforcement action by any governmental authority and shall be independent of any
governmentally mandated remediation. If Landlord approves the plan, then Tenant shall execute or cause the Tenant Party to execute the remediation plan at Tenant's sole cost and expense (subject to
such reimbursement as Tenant may obtain from a Tenant Party). If the remediation plan is not reasonably acceptable to Landlord or if Tenant fails to execute or cause execution of the remediation plan
within a reasonable period of time, then, at Landlord's option, Tenant shall reimburse Landlord, upon demand, for the cost to Landlord of performing rectifying work provided that such work is not in
excess of or to higher standards than would be mandated by applicable Environmental Laws. The reimbursement shall be paid to Landlord in advance of Landlord's performing such work, based upon
Landlord's reasonable estimate of the cost thereof; and upon completion of such work by Landlord, Tenant shall pay to Landlord any shortfall within thirty (30) days after Landlord bills Tenant
therefor or Landlord shall within thirty (30) days refund to Tenant any excess deposit, as the case may be. To the extent reasonably requested by Landlord, Tenant shall furnish Landlord with
detailed reports concerning any Environmental Condition which occurs on the Premises during the Term. 

13

 

    9.1.8  After notice to Tenant and a reasonable opportunity for Tenant to effect such compliance,
Landlord may, but shall not be obligated to, enter upon the Premises (including subleased Premises) and take such actions and incur such costs and expenses to effect such compliance as it deems
advisable to protect its interest in the Premises. However, Landlord shall not be obligated to give Tenant notice and an opportunity to effect compliance if (i) such delay might result in
material adverse harm to Landlord, the Premises, the Building or the Project; (ii) Tenant has already had actual knowledge of the situation and a reasonable opportunity to effect compliance, or
(iii) Landlord reasonably believes that an emergency exists. Landlord shall use good faith efforts to comply with Tenant's reasonable requirements with respect to security to the extent such
requirements have been provided to Landlord in advance. Whether or not Tenant has actual knowledge of the release of Hazardous Materials on the Premises, the Building, or the Project as the result of
Tenant's or Tenant Parties' use of the Premises, the Building or the Project, Tenant shall reimburse Landlord for all reasonable costs and expenses incurred by Landlord relating to such Hazardous
Materials or in connection with such compliance activities. Tenant shall notify Landlord immediately of any release of any Hazardous Materials on the Premises in violation of any Environmental Law of
which Tenant is aware. 

    9.1.9  Tenant agrees to indemnify, defend and hold harmless Landlord against any and all losses,
liabilities, suits, obligations, fines, damages (including diminution in the value of the Premises or Building, loss or restrictions on use of space in the Building or Project, and sums paid in
settlement of claims), judgments, penalties, claims, charges, cleanup costs, remedial actions, costs and expenses (including, without limitation, attorneys' and other professional fees and
disbursements) that may be imposed on, incurred or paid by, or asserted against Landlord, the Premises, the Building, or the Project by reason of, or in connection with (i) any
misrepresentation, breach of warranty or other default by Tenant or any Tenant Party under this Section, or (ii) the acts or omissions of Tenant or any Tenant Party resulting in the release of
any Hazardous Materials. All of Tenant's obligations and liabilities under this Section shall survive expiration or other termination of this Lease and shall be separately enforceable by Landlord.
This indemnification is intended to constitute an indemnity agreement within the meaning of Section 9607(e)(i) of the Comprehensive Environmental Response, Compensation and Liability Act
of 1980 (42 U.S.C. § 9607(e)(i)). Neither the written consent by Landlord to the presence of Hazardous Materials on, under or about the Premises, nor the strict compliance by Tenant with
all Environmental Laws, shall excuse Tenant from Tenant's obligation of indemnification pursuant thereto. 

    9.1.10  Landlord shall provide Tenant with exterior space for an enclosed Hazardous Materials waste
storage area (the "Hazardous Materials Storage Area") in a location mutually acceptable to Landlord and Tenant near the Generator (as defined below), which may be used by Tenant for storage of
Hazardous Materials pending pickup of such waste for disposal. Tenant shall be responsible for obtaining and keeping in force, at its cost, all required permits or licenses with respect to Tenant's
materials in the Hazardous Materials Storage Area. Tenant shall be responsible for the pick up and proper disposal of all materials placed in the Hazardous Materials Storage Area by Tenant, at
Tenant's sole cost and expense. The Hazardous Materials Storage Area will be about the size of 2 parking spaces and will mostly be used for flammable solvents. It will be self-contained
and installed, operated and maintained in compliance with best industry practice and all applicable regulations. 

    9.1.11  Upon expiration or early termination of this Lease, Tenant shall at its sole cost and expense
undertake and complete a thorough wash and decontamination of those portions of the Premises (including the Hazardous Materials Storage Area) that have or may have been exposed to Hazardous Materials,
including but not limited to scrubbing of all surfaces, equipment, cabinets, fixtures and flume hood external surfaces in the Premises, in order to remove all residues of 

14

 

Hazardous Materials (including chemicals and biological material). Upon completion of such wash and decontamination, Tenant shall cause, at its sole cost and expense, a reputable environmental
engineering company to perform an environmental inspection of the Premises and prepare a written report for delivery to Landlord and Tenant no later than 30 days after Lease expiration or early
termination, certifying that the Premises are free from all Hazardous Materials. 

    9.1.12  At its option, Landlord may once in each Lease year, and more frequently if Landlord has
reasonable cause to believe that a violation of Environmental Law or this Section 9 is occurring, monitor Tenant's and Tenant Parties' compliance with the requirements set forth in this
Section, including without limitation obtaining an environmental assessment of the Premises from a qualified environmental engineering company of Landlord's selection which has demonstrated industry
related experience, the cost of which shall be paid by Landlord unless such assessment shows a material failure by Tenant or Tenant Parties to comply with the requirements of this Section, in which
case the cost shall be paid by Tenant. Any such environmental assessment shall be performed at a reasonable time mutually acceptable to Landlord and Tenant (and coordinated with Tenant Parties).
Landlord shall provide a copy of any written assessment to Tenant and, Tenant shall comply (and cause Tenant Parties to comply), at Tenant's cost and expense (provided that Tenant may seek to have
Tenant Parties bear costs so long as the work is done), with any industry-standard recommendations contained in any such environmental assessment that Landlord may reasonably require including without
limitation, any recommended precautions which should be taken with respect to Tenant's or Tenant Parties' activities on the Premises. 

    9.1.13  Promptly after learning thereof, Landlord shall notify Tenant of any Environmental Condition on
the Project or any release of Hazardous Materials within the Project caused by Landlord or any occupant of the Building or Project other than the Tenant. Landlord obtained environmental inspections of
the Land prior to purchasing it and the reports did not disclose any Hazardous Materials. In addition, Landlord warrants that to the best of its knowledge, none of the construction materials for the
completion of the shell and core contained or will contain asbestos or other Hazardous Materials. Landlord agrees to indemnify, defend and hold harmless Tenant against any and all losses, liabilities,
suits, obligations, fines, damages, judgments, penalties, claims, charges, cleanup costs, remedial actions, costs and expenses (including, without limitation, attorneys' and other professional fees
and disbursements, but excluding consequential damages such as lost profits) that may be imposed on, incurred or paid by, or asserted against Tenant by reason of, or in connection with (i) any
misrepresentation, breach of warranty or other default by Landlord under this Section, or (ii) any
Hazardous Materials in, on or around the Project at the time Tenant takes possession of the Premises. All of Landlord's obligations and liabilities under this Section shall survive expiration or other
termination of this Lease and shall be separately enforceable by Tenant. 

10.  ALTERATIONS  

    10.1.  Procedures. Except for installation of Tenant Improvements pursuant to Exhibit C, Tenant
shall not make any alterations in the Premises without the prior written consent of Landlord, which consent shall not be unreasonably withheld for alterations not affecting building systems or
building structure if Tenant agrees, at its cost, to remove the alterations and repair any damage caused thereby at the end of the Term at Landlord's request. Tenant acknowledges that the amount of
laboratory space in the initial Tenant Improvements is unusual, and agrees that Landlord may consider the effect on releasing the Premises of construction of additional laboratory or specialty use
space after completion of both phases of the initial build out, and may condition consent to any such additional specialty space on the posting of a bond or increase in the Security Deposit to cover
the restoration of such space. Notwithstanding the above, Landlord's consent shall not be required, but Tenant shall notify Landlord at least 30 days in advance for alterations not affecting
building systems or building structure and 

15

 

costing less than $10,000 per alteration, or $25,000 aggregate per year. At the time of requesting Landlord's consent to alterations (or at the time of notice if Landlord's consent is not required),
Tenant may request that Landlord elect whether to require Tenant to remove such improvement or alteration upon expiration or termination of this Lease, and Landlord shall make such election at the
time of granting consent or within 15 days of the request if consent is not required. If Landlord fails to make such election, Landlord shall be deemed to have elected to have Tenant remove the
improvement or alteration. All alterations shall be made at Tenant's sole cost and expense and any contractor or person selected by Tenant to make alterations must first be approved in writing by
Landlord, which approval shall not be unreasonably withheld so long as the contractor and all subcontractors are signatory and in good standing with local unions (Landlord will work with Tenant to
identify qualifying contractors and subcontractors and shall only grant an exemption to this requirement if no qualified contractor or subcontractor is available after diligent research). All
alterations shall be made in a good and workmanlike manner and in compliance with all governmental requirements. Tenant shall indemnify and defend Landlord from all injury, loss, claims or damage to
any person or property in connection with Tenant's alterations. Tenant shall repair any damage and perform any necessary clean-up arising in connection with alterations. Tenant shall not
use any portion of the common areas in connection with an alteration without the prior written consent of Landlord. All alterations shall, upon expiration or sooner termination of this Lease, become
Landlord's property, unless Landlord requires that they be removed. If Tenant fails to remove any alterations which Landlord requires to be removed, they will be deemed to be abandoned by Tenant and
Landlord may remove them at Tenant's expense. 

    10.2.  Mechanic's Liens. Tenant shall have no authority, express or implied, to create or place any lien
or encumbrance of any kind or nature whatsoever upon, or in any manner to bind, the interest of Landlord in the Premises or the Project or to burden the rent payable hereunder for any claim in favor
of any person dealing with Tenant, including those who may furnish materials or perform labor for any construction or repairs, and each such claim shall affect and each such lien shall attach to, if
at all, only the leasehold interest granted to Tenant by this instrument. Tenant covenants and agrees that it will cause to be paid all sums payable by it for any labor performed or materials
furnished in connection with any work performed on the Premises on which any lien is or can be validly and legally asserted against its leasehold interest in the Premises or the improvements thereon
and that it will indemnify Landlord and hold Landlord harmless from any loss, damage or expense arising out of asserted claims or liens against the interest of the Landlord in the Premises or this
Lease. The foregoing shall not prevent Tenant from contesting in good faith any lien imposed provided that Tenant provides a bond or takes other measures sufficient to cause Landlord's title insurance
company to remove the lien from title. 

11.  DAMAGE OR DESTRUCTION  

    If the Premises or the Building is damaged by fire, vandalism, malicious mischief or any other occurrence, unless this Lease shall be terminated as hereinafter
provided, Landlord shall diligently proceed to repair or restore the basic Building Shell and all improvements required to be or actually insured by Landlord to the condition in which they existed
immediately prior to such destruction or damage, to the extent of the available insurance proceeds plus deductibles (or, if Landlord fails to maintain insurance then to the extent that insurance plus
deductibles would have been available had Landlord maintained the required insurance), and subject to delays which may arise by reason of adjustment of loss under insurance policies and delays beyond
the reasonable control of Landlord. Tenant shall fully and completely repair or replace any damage to improvements installed by Tenant and any damage to trade fixtures, furniture or equipment. If the
Premises are rendered entirely or partially untenantable, the Base Rent shall be reduced by the percentage equal to the percentage of the area of the Premises which is rendered unusable until the
Landlord's repairs are completed unless the damage resulted from the actions or omissions of Tenant, Tenant's employees or agents, in which case there shall be no such abatement. If the damage to the
Premises or the Building is so extensive that 

16

 
Landlord reasonably estimates that it cannot be repaired within 270 days of the date of damage, Landlord shall so notify Tenant and either party may terminate this Lease within fifteen
(15) days after the giving of such notice (provided that if the damage is due to the activities of Tenant, Tenant shall not be entitled to terminate unless the damage cannot be repaired within
360 days of the date of the damage). In the event of such termination Base Rent and other charges shall be adjusted to the date of such damage and Tenant shall thereupon promptly vacate the
Premises, the Lease shall terminate and neither party shall have any liability to the other under this Lease for any obligations arising after the termination. 

12.  INDEMNIFICATION AND RELEASE  

    12.1.  Indemnity. Tenant shall indemnify and defend (using legal counsel reasonably acceptable to
Landlord) Landlord and its mortgagees, agents, and employees from any claims, expenses (including attorneys' fees) or damages (excluding consequential damages unless caused by Tenant's release of
Hazardous Materials) to the extent arising in connection with the occupancy or use of the Premises by Tenant, its agents, customers, or employees (including, without limitation, any work undertaken or
contracted for by Tenant), provided that this indemnity shall not apply to claims for physical damage to persons or property to the extent caused by Landlord's gross negligence or willful misconduct.
Landlord shall indemnify and defend (using counsel reasonably acceptable to Tenant), its agents and employees from any claims, expenses (including attorneys' fees) for physical damage to persons or
property (but excluding consequential damages such as lost profits) to the extent caused by the gross negligence or willful misconduct of Landlord. The provisions of this Section 12 shall
survive expiration or termination of this Lease and shall include, but not be limited to, all claims against either party by any employee or former employee of the indemnifying party, and each party
agrees that the provisions of any employee injury insurance act, including Title 51 of the Revised Code of Washington, or any other employee benefit act shall not operate to release the indemnifying
party from its obligations under this Section 12. 

    12.2.  Waivers of Subrogation. Notwithstanding any other provision of this Lease, it is the intention of
the parties that each of them shall insure its real and personal property and interests therein, including economic interests, as and to the extent it sees fit. Each of Landlord and Tenant, on behalf
of its insurers, waives and releases any right of subrogation for damage to that party's real or personal property located anywhere in, on or about the Project, provided that in the event Landlord
maintains environmental insurance for which Tenant is not charged, there shall be no release or waiver of subrogation relating to such insurance and Tenant's indemnities, pursuant to Section 9
shall be primary to and not released by virtue of environmental insurance for which Tenant is not charged. 

    12.3.  Limitation on Indemnity. In compliance with RCW 4.24.115 as in effect on the date of this Lease,
all provisions of this Lease pursuant to which Landlord or Tenant (the "Indemnitor") agrees to indemnify the other (the "Indemnitee") against liability for damages arising out of bodily injury to
Persons or damage to property relative to the construction, alteration, repair, addition to, subtraction from, improvement to, or maintenance of, any building, road, or other structure, project,
development, or improvement attached to real estate, including the Premises, (i) shall not apply to damages caused by or resulting from the sole negligence of the Indemnitee, its agents or
employees, and (ii) to the extent caused by or resulting from the concurrent negligence of (a) the Indemnitee or the Indemnitee's agents or employees, and (b) the Indemnitor or
the Indemnitor's agents or employees, shall apply only to the extent of the Indemnitor's negligence; PROVIDED, HOWEVER, the limitations on indemnity set forth in this Section shall automatically and
without further act by either Landlord or Tenant be deemed amended so as to remove any of the restrictions contained in this Section no longer required by then applicable law. 

17

 

    12.4.  Definitions. As used in any Section in connection with establishing indemnity or release of
Landlord, "Landlord" shall include Landlord, its partners, officers, agents, employees and contractors, and "Tenant" shall include Tenant and any person or entity claiming through Tenant. 

13.  EMINENT DOMAIN  

    To the best of Landlord's knowledge as of the date of this Lease, there are no current or pending actions to condemn any portion of the Project, nor any
current or pending governmental eminent domain claims that would affect the Project. If the entire Project is condemned or taken for any public or quasi-public purpose, including any purchase in lieu
of condemnation, this Lease shall terminate as of the date of taking of possession for such use or purpose. If a portion of the Project is condemned or taken, (whether or not the Premises be
affected), Landlord may, by notice to Tenant, terminate this Lease as of the date of the taking of possession for such purpose. If Landlord does not terminate this Lease, and if the taking results in
a reduction in the occupiable square footage of the Premises, then the Base Rent shall be reduced pro-rata, and Landlord shall repair the remaining part of the Premises to substantially
its former condition to the extent reasonably feasible, provided that if the condemnation causes the Premises to be unusable for Tenant's Permitted Use, Tenant may terminate this Lease by giving
notice within ten (10) days after notification by Landlord of the intended extent of the taking, such termination to be effective on the date of the Taking. Landlord shall be entitled to the
entire award in any condemnation proceeding, including any award for the value of any unexpired term of this Lease, and shall have the exclusive authority to settle the condemnation proceeding, and
the exclusive discretion to grant "possession and use" to the condemning authority, and Tenant shall have no claim against Landlord or against the proceeds of the condemnation except that Tenant shall
have the right to bring a separate action to recover compensation for Tenant's moving expenses. 

14.  ASSIGNMENT AND SUBLETTING  

    14.1.  Assignment or Sublease. Tenant shall not assign this Lease or sublet the whole or any part of the
Premises (any of which events being a "Transfer" and any assignee or sublessee being a "Transferee") without Landlord's prior written consent which shall not be unreasonably withheld provided the
Transferee meets all of the requirements in Section 14.7. To assist Landlord in determining whether to consent to a Transfer, Tenant shall submit the following to Landlord, as well as any other
information reasonably requested by Landlord, (i) the name and legal entity of the Transferee; (ii) a description of the proposed use of the Premises by the Transferee; (iii) the
terms of the proposed Transfer; (iv) past three years plus current financial statements and the most recent filed federal income tax return of the proposed Transferee; and (v) the
proposed Transfer documents. The parties agree that the 3 years of financial statements is not a mandatory requirement but is only a factor that the Landlord may reasonably consider when
deciding whether to consent to a proposed sublease or assignment and provided further that such factor shall not be considered at all with respect to initial subleasing of the Secondary Space (as
defined in Exhibit C). No Transfer shall affect the liability of Tenant under this Lease, and Tenant and its Transferee shall continue to remain liable to Landlord for performance of Tenant's
and its Transferee's obligations under this Lease. Consent to any Transfer shall not operate as a waiver of the necessity of a consent to any subsequent Transfer. Any bankruptcy filing by or against
Tenant shall void all of Tenant's rights to assign this Lease or sublet the Premises. 

    14.2.  Entity Ownership. The cumulative transfer of an aggregate of 50% or more of the voting interests
in Tenant (stock in a corporation, partnership interests in a partnership, or ownership interests in a limited liability company), including by creation or issuance of new ownership interests of an
entity which is (i) Tenant; (ii) an assignee of Tenant; or (iii) an entity which is a general partner in a general or limited partnership which is Tenant or assignee of this Lease
(except as the result of transfers by gift 

18

 

or inheritance) shall be deemed a Transfer of this Lease. No such assignment shall release Tenant from its obligations hereunder. 

    14.3.  Assignee Obligation. Any assignee shall assume all obligations of Tenant and shall be jointly and
severally liable with Tenant for the payment of Base Rent, additional rent and all other charges and performance of all of Tenant's obligations under this Lease. Any sublessee shall assume all
obligations of Tenant to the extent they relate to the subleased premises. Tenant shall provide Landlord duplicate originals of all instruments of assignment, sublease or assumption. If the Transferee
defaults, Landlord may, without affecting any other rights of Landlord, proceed against Tenant or any Transferee or any other person liable for Tenant's obligations hereunder. 

    14.4.  Fees. Any request for consent to a Transfer shall be accompanied by payment of a
non-refundable fee of $1,500 to compensate Landlord for the administrative burden of processing the request. In addition, Tenant shall reimburse Landlord for any
out-of-pocket costs incurred by Landlord in connection with the request. 

    14.5.  Assignment to Affiliate; Going Public. Tenant shall not be required to obtain Landlord's consent
to assign the Lease to (i) a company wholly owned by Tenant or (ii) a company under common control with Tenant or (iii) a company that acquires Tenant or into which Tenant is
merged so long as the net worth of the resulting company is equal to or greater than the greater of the net worth of Tenant at the time of full execution of this Lease or the net worth of Tenant
immediately prior to the merger, but in all such events Tenant will provide to Landlord (i) the name and legal entity of the Transferee; (ii) a description of the proposed use of the
Premises by the Transferee; (iii) a summary of the terms of the proposed Transfer; (iv) past three years plus current financial statements, if available, and the most recent filed
federal income tax return of the proposed Transferee; and (v) a summary of the proposed Transfer documents all prior to the effective date of the assignment. No such assignment shall release
Tenant from its obligations hereunder. Notwithstanding any other provision of this Lease, a public offering, sale or transfer of equity in the Tenant entity, whether characterized as common or
preferred stock or any other ownership interest conducted in accordance with the Securities Act of 1933, as amended, shall not require Landlord's consent pursuant to this Section (but Tenant shall
notify Landlord of such event not less than 10 days prior to its occurrence). No such assignment shall release Tenant from its obligations hereunder except in the case of a merger or
acquisition in which Tenant is not the surviving entity. Sections 14.1, 14.4, 14.6, 14.7 and 14.8 shall not apply to transfers permitted under this Section 14.5 where Landlord's consent is not
required. 

    14.6.  Assignment/Subletting Income. Seventy-five percent of any amounts payable by an assignee to Tenant
which exceed the Rent payable by Tenant hereunder, whether in the form of assignment fees or increased Base Rent or otherwise, shall be immediately paid on to Landlord as additional rent; provided
that Tenant shall be permitted to deduct amortization of Tenant's out of pocket costs for the assignment, spread over the remaining lease term. Seventy-five percent of any amounts payable by a
sublessee which exceed, on a per square foot basis, the rent due from Tenant hereunder shall be immediately paid on to Landlord; provided that Tenant shall be permitted to deduct amortization of
Tenant's reasonably supported out of pocket costs for the sublease, amortized over the sublease term. This Section 14.6 shall not apply to transfers pursuant to Section 14.5. 

    14.7.  Transfer Standards. All of the following requirements must be met before Landlord will be required
to not unreasonably withhold its consent to a Transfer: 

    14.7.1. Transferee's uses (i) are consistent with the permitted uses in Section 1.6 and
compatible with the other uses in the Building and with operation of a first class office building and do not create any
increased risk of Hazardous Material contamination or increased cost to Landlord of monitoring or handling same; (ii) do not increase the risk of damage or wear and tear on the Building;
(iii) do not require increased utility service or increased services from Landlord or changes in the Premises (iv) do not increase the insurance costs of the Landlord. 

19

 

    14.7.2.  Either (i) the financial resources of Tenant have not significantly declined since the
date of this Lease, or (ii) Transferee's financial status and creditworthiness is comparable to other tenants of similar amounts of space in the Building. 

    14.8.  Landlord's Recapture Right. In lieu of granting consent to any proposed Transfer (except a
transfer pursuant to Section 14.5 or a sublease for less than five (5) years where the total area then under sublease by Tenant is less than 25,000 rentable square feet), Landlord
reserves the right to terminate this Lease or, in the case of subletting of less than all the Premises, to terminate this Lease with respect to such portion of the Premises, as of the proposed
effective date of such Transfer, in which event Landlord may enter into the relationship of landlord and tenant with any third party for that space. 

15.  INSOLVENCY AND DEFAULT  

    15.1.  Defaults. If: (i) Tenant fails to pay any installment of Base Rent or other charges
hereunder when due, or (ii) Tenant fails to perform any other covenant, term, agreement or condition of this Lease, or (iii) a Financial Distress Default occurs, then, if the default is
not cured within the cure periods set forth below, Landlord may, immediately or at any time thereafter, elect to terminate this Lease by notice, by lawful entry or otherwise, whereupon Landlord shall
be entitled to recover possession of the Premises from Tenant and those claiming through or under Tenant. Tenant shall have 5 days after notice of monetary default to cure the default. Tenant
shall have 20 days after notice of a non-monetary default to cure the default; provided that if the default cannot be cured within 20 days, then Tenant shall be granted such
additional time to cure the default as is reasonably necessary if Tenant commences the cure within the 20-day period and diligently pursues the cure to completion. Termination of this
Lease and any repossession shall be without prejudice to any remedies Landlord has for arrears of rent or for a prior breach of any of the provisions of this Lease. 

    In
case of such termination, Tenant shall indemnify Landlord against all costs and expenses including the amounts due under Section 15.2 and loss of rent. If Tenant fails to
perform any of Tenant's
covenants which Tenant has failed to perform at least twice previously in any 12-month period (although Tenant shall have cured any such previous breaches after notice from Landlord, and
within the notice period), then Landlord may thereafter, without further notice, exercise any remedies permitted by this Section 15 or by law, including but not limited to termination of this
Lease. 

    15.2.  Expense Recovery. Items of expense for which Tenant shall indemnify Landlord shall include but not
be limited to: (i) all costs and expenses incurred in collecting amounts due from Tenant under this Lease or obtaining Tenant's compliance with this Lease (including attorneys' fees);
(ii) the unamortized portion of (a) leasing commissions paid in connection with this Lease, and (b) all costs incurred by Landlord to improve the Premises (such amortization to be
based on a straight line basis over the initial Term with interest at 13%); and (iii) all Landlord's other costs proximately caused by the termination. The above sums shall be due and payable
immediately upon notice from Landlord without regard to whether the cost or expense was incurred before or after the termination of this Lease. If proceedings are brought under the Bankruptcy Code,
including proceedings brought by Landlord, which relate in any way to this Lease (in any of such cases a "Proceeding"), then Landlord shall be paid the costs incurred by Landlord in connection with
the Proceedings. 

    15.3.  Damages. Notwithstanding termination of this Lease and reentry by Landlord pursuant to
Section 15.1, Landlord shall be entitled to recover from Tenant: 

    15.3.1.  The worth at the time of an award (including interest at the rate set forth in
Section 15.7), of any unpaid rent which had been earned by Landlord prior to the time of termination; plus 

20

  

    15.3.2.  The worth at the time of an award (including interest at the rate set forth in
Section 15.7), of the amount by which the unpaid rent which would have been earned after termination until the time of an award exceeds the amount of loss of rent that Tenant proves could have
been reasonably avoided; plus 

    15.3.3.  The worth at the time of an award of the amount by which the unpaid rent and additional rent
for the balance of the term of this Lease (as extended, if at all prior to termination) exceeds the amount of such loss of rent and additional rent that Tenant proves could have been reasonably
avoided (including interest at the rate set forth in Section 15.7 from the date of the award until paid). Such worth of the time of award shall be computed at the discount rate of the Federal
Reserve Bank of San Francisco, or successor Federal Reserve Bank, on the date of termination; plus 

    15.3.4.  Any other amount necessary to compensate Landlord for all the damage proximately caused by
Tenant's failure to perform Tenant's obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, including amounts due and payable pursuant to
Section 15.2. 

    15.4.  Non-Termination of Lease. No act of Landlord other than a written declaration of
termination of Lease shall serve to terminate this Lease. If Landlord reenters the Premises pursuant to Section 15.1, and does not elect to terminate this Lease, Tenant shall indemnify Landlord
for the loss of rent by a payment at the end of each month during the remaining Term representing the difference between the Base Rent, and other charges which would have been paid in accordance with
this Lease and the rental actually derived from the Premises by Landlord for such month. Separate actions may be maintained by Landlord against Tenant from time to time to recover any damages which,
at the commencement of any action, are then due and payable to Landlord under this Section 15 without waiting until the end of the Term of this Lease. 

    15.5.  Reletting. If this Lease is terminated, Landlord may at any time, and from time to time, relet the
Premises in whole or in part either in its own name or as agent of Tenant for any period equal to or greater or less than the remainder of the then-current Term. All rentals received by
Landlord from such reletting shall be applied first to the payment of any amounts other than rent due hereunder from Tenant to Landlord; second, to the payment of any costs and expenses of such
reletting and of alterations and repairs; third, to the payment of rent and additional rent due and unpaid hereunder; and the residue, if any, shall be held by Landlord and applied in payment of
future rent and additional rent as they become due hereunder. Upon a reletting of the Premises, Landlord shall not be required to pay Tenant any sums received by the Landlord in excess of amounts
payable in accordance with this Lease. 

    15.6.  Right of Landlord to Cure Defaults. If Tenant defaults under this Lease, Landlord may cure the
default, at Tenant's expense, immediately and without notice in case of emergency threatening harm to persons or property, or in any other case only upon Tenant's failure to remedy such default within
20 days after Landlord notifies Tenant in writing of such default. Tenant shall reimburse Landlord for any costs of the cure with interest pursuant to Section 15.7. Landlord shall have
the same rights and remedies as for the non-payment of sums due under this Section 15 as in the case of default by Tenant in the payment of rent or additional rent. 

    15.7.  Unpaid Sums and Service Charge. Any amounts owing from Tenant to Landlord under this Lease shall
bear interest at 18% per annum, calculated from the date due or expended until the date of payment. In addition, if any payment of rent, or other charges, is not paid within 10 days of its due
date, Tenant shall pay a late charge equal to the greater of $150 or 10% of the overdue amount as liquidated damages for Landlord's extra expense and handling of such past due account. 

21

 

    15.8.  Financial Distress. 

    15.8.1.  Definition.  Each of the following shall be an "Event of Financial Distress" and shall represent
a default under this Lease unless cured within the cure periods set forth below: (a) the making by Tenant of any general assignment or general arrangement for the benefit of creditors; the
filing by or against Tenant of a petition to have Tenant adjudged a bankrupt, or a petition for reorganization or arrangement under any law relating to bankruptcy; (b) the appointment of a
trustee or a receiver to take possession of all or any part of Tenant's assets; or (c) the entry of any final or unbonded judgment against Tenant which is not covered by insurance proceeds or
which exceeds $2,000,000. Tenant shall immediately notify Landlord upon the occurrence of any Event of Financial Distress. Tenant shall have 60 days to cure a default under clause (a)
above by having the petition dismissed. Tenant shall have 30 days to cure a default under clause (b) above by having the trustee or receiver dismissed or otherwise regaining possession
of Tenant's assets. Tenant shall have 30 days to cure a default under clause (c) above by having the judgment discharged or satisfied. If the particular Event of Financial Distress is
not eliminated within the time periods provided above, then the provisions of Section 15.8.2 shall apply. 

    15.8.2.  Filing of Petition.  If a petition ("Petition") is filed by or against Tenant (as either debtor
or debtor-in-possession) under Title 11 of the United States Code (the "Bankruptcy Code") and same is not dismissed within 60 days thereafter: 

    (a)   Adequate
protection for Tenant's Lease obligations accruing after filing of the Petition shall be provided within 15 days after filing in
the form of a deposit equal to one month's Base Rent and Additional Rent (in addition to the security deposit), to be held by the court or an escrow agent approved by Landlord and the court. 

    (b)   All
amounts payable by Tenant to Landlord under this Lease represent reasonable compensation for the occupancy of the Premises by Tenant. 

    (c)   Tenant
or Trustee shall give Landlord at least 30 days written notice of any abandonment of the Premises or proceeding relating to
administrative claims. If Tenant abandons without notice, Tenant or Trustee shall stipulate to entry of an order for relief from stay to permit Landlord to reenter and relet the Premises. 

    (d)   If
Tenant was in default under the Lease before the filing of the Petition, whether or not Landlord has given Tenant written notice of that default
and whether or not any cure period expired before filing the Petition, Tenant shall be deemed to have been in default on the date the Petition was filed for all purposes under the Bankruptcy Code. 

    (e)   For
purposes of Section 365(b)(1) of the Bankruptcy Code, prompt cure of defaults shall mean cure within 30 days after assumption and
shall include cure of any defaults under any other agreements between Landlord and Tenant. 

     (f)   For
the purposes of Section 365(b)(1) the Bankruptcy Code, adequate assurance of future performance of this Lease by Tenant, Trustee or any
proposed assignee of the Lease will require that Tenant, Trustee or the proposed assignee deposit 2 months of Base Rent and Additional Rent payments into an escrow fund (to be held by the court
or an escrow agent approved by Landlord and the court) as security for such future performance. In addition, if the Lease is to be assigned, adequate assurance of future performance by the proposed
assignee shall require that: (i) the assignee have a tangible net worth not less than $1,000,000 or that such assignee's performance be unconditionally guaranteed by a person or entity that has
a tangible net worth not less than the above amount; (ii) assignee assume in writing all of Tenant's obligations under the Lease. 

22

 

    (g)   If Tenant or Trustee intends to assume and/or assign the Lease, Tenant or Trustee shall provide Landlord with 30 days written notice of the
proposed action, separate from and in addition to any
notice provided to all creditors. Notice of a proposed assignment and assumption shall state the assurance of prompt cure, compensation for loss and assurance of future performance to be provided to
Landlord. Notice of a proposed sale shall state: (i) the name, address, and federal tax identification numbers and registration numbers of the proposed assignee; (ii) all of the terms
and conditions of the proposed assignment, and (iii) the assignee's proposed adequate assurance of future performance to be provided to Landlord. 

16.  QUIET ENJOYMENT  

    Landlord covenants that upon Tenant's paying Base Rent, Additional Rent, and all other charges due hereunder and performing all obligations of this Lease on
its part to be performed, Tenant's occupancy shall not be interrupted by those claiming under Landlord, subject, however, to the terms and conditions of this Lease. 

17.  LIABILITY  

    17.1.  Landlord's Liability. The liability of Landlord to Tenant shall be limited to the interest of
Landlord in the Project and the rents and proceeds (including current and future rents and insurance proceeds) thereof. Tenant agrees to look solely to Landlord's interest in the Project and the rents
and proceeds (including current and future rents and insurance proceeds) thereof for the recovery of any judgment against Landlord, and Landlord and its partners shall not be personally liable for any
such judgment or deficiency after execution thereon or matters related to this Lease. In addition, if Landlord sells or otherwise transfers the Project to a new owner, the transferring Landlord shall
not thereafter be named or sought after in any matter related to the Project accruing from and after the date of such transfer. Upon transfer of ownership of the Project, Landlord's obligations under
this Lease shall automatically transfer to the new owner. 

    17.2.  Tenant's Business Interruption. Notwithstanding any other provision of this Lease, and to the
fullest extent permitted by law, Tenant hereby agrees that Landlord shall not be liable for injury to Tenant's business or any loss of income therefrom, whether such injury or loss results from
conditions arising upon the Premises or the Project, or from other sources or places including, without limitation, any interruption of services and utilities described in Section 7 or any
casualty, condemnation, or from any cause whatsoever, including, date sensitive microprocessors, and regardless of whether the cause of such injury or loss or the means of repairing the same is
inaccessible to Landlord or Tenant. Tenant may elect, at its sole cost and expense, to obtain business interruption insurance with respect to such potential injury or loss. 

  SUBORDINATION AND ESTOPPEL  

    18.1.  Subordination. Landlord warrants that there is no existing deed of trust on the Project. This
Lease shall be subordinate to any financing now existing or hereafter placed upon any of the Project by Landlord, and to any and all advances to be made thereunder and to interest thereon and all
modifications thereof (each, a "Mortgage") provided that so long as Tenant is not in default hereunder beyond any applicable cure period Tenant shall have continued enjoyment, possession, use and
occupancy of the Premises and any and all rights under this Lease for the term of this Lease and any extensions thereof free from any disturbance or interruption by reason of any foreclosure of any
such deed of trust, mortgage or the exercise of any remedies by the holder thereof. This subordination provision shall be self-operative but Landlord shall use reasonable efforts to obtain
a nondisturbance agreement from any existing lender whose loan is senior to this Lease. Tenant shall execute and deliver any reasonable subordination agreement required by the holder of a Mortgage,
but only if any such 

23

 

subordination agreement provides that so long as Tenant is not in default under this Lease, Tenant shall have the continued enjoyment of the Premises free from any disturbance or interruption by any
holder of a Mortgage or any purchaser at a foreclosure or private sale of the Project and does not impose any additional obligations on Tenant or seek to modify this Lease in any manner. 

    18.2.  Attornment. If Landlord's interest in the Premises is acquired by any ground lessor, beneficiary
under a deed of trust, mortgagee, or purchaser at a foreclosure sale, Tenant shall attorn to the transferee of or successor to Landlord's interest in the Premises and recognize such transferee or
successor as Landlord under this Lease; provided that Landlord's successor in interest or any person to whom Tenant is asked to attorn shall agree in a writing that, so long as Tenant is not in
default hereunder, this Lease shall remain in full force and effect for the full term hereof (including any extensions, renewals or options). Tenant waives the protection of any statute or rule of law
which gives or purports to give Tenant any right to terminate this Lease or surrender possession of the Premises upon the transfer of Landlord's interest. 

    18.3.  Estoppel Certificates. Tenant shall, within 15 days of demand, execute and deliver to
Landlord a written statement certifying: (i) the commencement and the expiration date of the Term; (ii) the amount of Base Rent and the date to which it has been paid; (iii) that
to the best of Tenant's knowledge this Lease is in full force and effect and has not been assigned or amended in any way (or specifying the date and terms of each agreement so affecting this Lease)
and that no part of the Premises has been sublet (or to the extent such is not the case, a copy of any sublease); (iv) that to the best of Tenant's knowledge Landlord is not in default under
this Lease (or if such is not the case, the extent and nature
of such default); (v) on the date of such certification, to the best of Tenant's knowledge there are no existing defenses or claims which Tenant has against Landlord (or if such is not the
case, the extent and nature of such defenses or claims); (vi) the amount of the Security Deposit held by Landlord; and (vii) any other fact or representation that a mortgagee or
purchaser may reasonably request. It is intended that any such statement shall be binding upon Tenant and may be relied upon by a prospective purchaser or mortgagee. If Tenant fails to respond within
15 days of receipt of a written request by Landlord therefor, (a) Tenant shall be deemed to have given a certificate as above provided, without modification, and shall be conclusively
deemed to have admitted the accuracy of any information supplied by Landlord on the form provided to Tenant for execution, and (b) if such failure to respond is not cured within three
(3) days after a notice from Landlord that such estoppel certificate is overdue, Landlord may impose a fee of $100 per day for each day of delay in providing the statement by Tenant after the
expiration of the three (3) day additional notice period. 

19.  HOLDING OVER  

    If Tenant fails to surrender possession of the Premises upon termination or expiration of this Lease, and if Tenant obtains Landlord's written consent to
Tenant's continued occupancy, then Tenant's occupancy shall be deemed to be a month to month tenancy, with Base Rent due at a rate one and one half times the rate payable by Tenant hereunder during
the calendar month immediately preceding such termination or expiration (the "Latest Rate") and Landlord may terminate such month to month tenancy upon 20 days notice to Tenant. If Tenant fails
to surrender possession of the Premises upon termination or expiration of this Lease and if Tenant does not obtain Landlord's written consent to Tenant's continued occupancy, then Tenant shall be
deemed a trespasser and shall be liable to Landlord for all damages sustained by Landlord as a result thereof, together with Base Rate at a rate double the Latest Rate. 

20.  MISCELLANEOUS PROVISIONS  

    20.1.  Heirs and Assigns. Subject to provisions hereof restricting transfers, all of the terms contained
in this Lease shall inure to the benefit of and be binding upon Landlord and Tenant and 

24

 

their respective heirs, executors, administrators, successors and assigns. If more than one person or entity executes this Lease as Tenant, the liability of each shall be deemed to be joint and
several. 

    20.2.  Non-Waiver. Failure of Landlord to insist, in any one or more instances, upon strict
performance of any term of this Lease, or to exercise any option herein contained, shall not be construed as a waiver or a relinquishment for the future, of such term or option, but the same shall
continue and remain in full force and effect. The receipt by Landlord of rent or other payments with knowledge of a breach of any of the terms of this Lease by Tenant shall not be deemed a waiver of
such breach except to the extent of the payment. Landlord shall not be deemed to have waived any provision of this Lease unless expressed in writing and signed by Landlord. Tenant specifically
acknowledges and agrees that, where Tenant has received a notice to cure default, no acceptance by Landlord of rent shall be deemed a waiver of such notice, and, including but without limitation, no
acceptance by Landlord of partial rent shall be deemed to waive or cure any rent default. Landlord may, in its discretion, after receipt of partial payment of rent, refund same and continue any
pending action to collect the full amount due, or may modify its demand to the unpaid portion. In either event the default shall be deemed uncured until the full amount is paid in good funds. 

    20.3.  Brokers. Except as specified in Section 1, each party represents and warrants to the other
that it has not engaged any broker, finder or other person entitled to any commission or fee in respect of the negotiation, execution or delivery of this Lease, and each party shall indemnify and
defend the other against any claims for such commission arising out of agreements made or alleged to have been made by or on behalf of the first party, provided only that Landlord agrees to pay the
brokers specified in Section 1 a commission pursuant to separate written agreement. Landlord and Tenant recognize that it is possible that they may hereafter make additional agreements
regarding further extension or renewal of this Lease or a new lease or leases for all or one or more parts of the Premises or other space in the Project for a term or terms commencing after the
Commencement Date of this Lease. Landlord and Tenant recognize that it is also possible that they may hereafter modify this Lease to add additional space or to substitute space as part of the
Premises. If any such additional agreements, new leases or modifications to this Lease are made, or if Tenant exercises any options to extend this Lease, or if Tenant exercises any options to extend
the lease term, Landlord shall not have any obligation to pay any compensation to any real estate broker engaged by Tenant or to any other third person engaged by Tenant to render services to Tenant
in connection with negotiating such matters, regardless of whether under the circumstances such person is or is not regarded by the law as an agent of Landlord. 

    20.4.  Entire Agreement. This Lease and the Exhibits thereto contains the entire agreement of the parties
with respect to the subject matter hereof and no representations, promises or agreements, oral or otherwise, between the parties not embodied herein shall be of any force or effect. No provisions of
this Lease may be changed, waived, discharged or terminated orally, but only by instrument in writing executed by Landlord and Tenant concurrently with or subsequent to the date of this Lease. 

    20.5.  Inability to Perform. If Landlord is unable to perform, or is delayed in performing, any of its
obligation under this Lease, for reason of acts of God, accidents, breakage, repairs, maintenance, strikes, lockouts, other labor disputes, inability to obtain utilities or materials, or by any other
reason beyond Landlord's reasonable control, then except as otherwise provided herein no such inability or delay by Landlord shall constitute an actual or constructive eviction, in whole or in part,
or entitle
Tenant to any abatement or diminution of Base Rent or Additional Rent, or relieve Tenant from any of its obligations under this Lease, or impose any liability upon Landlord or its agents by reason of
the inconvenience, annoyance, interruption, injury or loss to or interference with Tenant's business or use and occupancy or quiet enjoyment of the Premises or any loss or damage occasioned thereby. 

25

  

    20.6.  Severability. Any provision of this Lease which shall prove to be invalid, void or illegal shall
in no way affect, impair or invalidate any other provision hereof and the remaining provisions hereof shall nevertheless remain in full force and effect. 

    20.7.  Tenant's Audit Right. Tenant shall have the right to audit the current fiscal year's expense
statement issued by or on behalf of Landlord by written notice given to Landlord within 60 days after receipt of that statement. Such audit shall be conducted in the offices of Landlord's
property manager at the cost of Tenant. Tenant shall pay to the property manager its standard hourly rates for the time spent by the property manager's principals and employees in connection with
Tenant's audit. Tenant shall keep all of the information disclosed in the course of such audit confidential (provided that it may be disclosed to its attorneys and financial advisors), and shall
require all of its consultants to agree in writing directed to the Landlord to keep all such information confidential. Tenant agrees that such audits shall not be permitted to be conducted on a
contingency fee basis. Should such audit uncover either an overage or a shortage of expenses charged to the Tenant greater than 3% for the year's period being audited, the correcting amount shall be
paid to the counterparty within 30 days thereafter. 

    20.8.  No Accord or Satisfaction. Payment by Tenant or receipt by Landlord of a lesser amount than the
rent and other charges stipulated herein shall be deemed to be on account of the earliest stipulated rent or other charges. No endorsement or statement on any check or any letter accompanying any
payment shall be deemed an accord and satisfaction, and Landlord's acceptance of such check or payment shall be without prejudice to Landlord's right to recover the balance of the amount due or pursue
any other remedy to which it is entitled. 

    20.9.  Notices. All notices under this Lease shall be in writing and sent by courier, by registered or
certified mail, return receipt requested, or recognized overnight courier at the following addresses: 

    Landlord:  

    Rent:  Checks
are to be made payable to Landlord's property manager, Trammel Crow Company and sent to: 

Trammell
Crow Company

ITF WCM 132-302, LLC

Department 421

P.O. Box 34935

Seattle, WA 98124-1935 

    Building
Operations: Notices related to building operations are to be sent to: 

WCM
132-302, LLC

c/o Trammell Crow Company

900 Fourth Avenue, Suite 3300

Seattle, Washington 98164 

    For
all other issues, notices are to be sent to: 

WCM
132-302, LLC

c/o Barnes & Nelson Union Partners, LLC

3245 146th Place SE, Suite 290

Bellevue, WA 98007 

    Tenant:  

Seattle
Genetics Inc.

Attn.: Tim Carroll, CFO

21823 30th Avenue S.E., Suite 100

Bothell, WA 98021 

26

 

or
such other single address as may hereafter be designated by either party in writing. Notices shall be deemed given if mailed by registered or certified mail 3 days after deposit in the U. S.
Mail, postage
prepaid and if sent by overnight courier, the date after deposit with the courier. If the intended recipient receives the notice at the address required by this Section 20.9 but refuses to
accept it, the notice shall be deemed received on that day of rejection. Tenant hereby appoints as its agent to receive the service of all dispossessory or distraint proceedings and notices thereunder
the person in charge of or occupying the Premises at the time, and, if no person shall be in charge of occupying the same, then such service may be made by attaching the same to the entrance of the
Premises. 

    20.10.  Waiver of Self-Help. Tenant waives any statutory or common law right to
self-help, including any right to make repairs to the Building or common areas. 

    20.11.  Tax on Rent. The rent herein is exclusive of any sales, gross receipts or other tax based on
rents, or tax on Tenant's property or tax upon or measured by the number of employees of Tenant, or any similar tax or charge. If any such tax or charge be hereinafter enacted and imposed upon
Landlord, Tenant shall pay Landlord the amount thereof concurrently with each monthly rent payment. If it shall not be lawful for Tenant to reimburse Landlord, the monthly rent payable to Landlord
under this Lease shall be revised to net Landlord the same net rental after imposition of any such tax or charge upon Landlord as would have been payable to Landlord prior to the imposition of such
tax or charge. Tenant shall not be liable to reimburse Landlord for any federal income tax or other income tax of a general nature applicable to Landlord's income. 

    20.12.  Right to Change Public Spaces. Landlord reserves the right at any time, without thereby creating
an actual or constructive eviction or incurring any liability to Tenant, to change the arrangement or location of public areas of the Project not contained within the Premises or any part thereof,
including entrances, passageways, parking lots and other public service portions of the Project, provided that Tenant's access to and use of the Premises shall not be materially adversely affected
thereby. 

    20.13.  Consent. Notwithstanding anything contained in this Lease to the contrary, Tenant shall have no
claim, and hereby waives the right to any claim against Landlord for money damages by reason of any refusal, withholding or delaying by Landlord of any consent, approval or statement of satisfaction,
and in such event, Tenant's only remedies therefore shall be an action for specific performance, injunction or declaratory judgment, to enforce any right to such consent. 

    20.14.  Financial Statements. Upon request by Landlord, Tenant shall provide to Landlord copies of
Tenant's most recent financial statements and tax returns (which financial statements may be supplied by reference to the electronic location from which they may be downloaded without charge if so
published). Any non-public information gained from such financial statements or inspections furnished to or conducted by or on behalf of Landlord shall be confidential and shall not be
disclosed other than to carry out the purposes hereof; provided, however, Landlord shall be permitted to divulge the contents of any such statements in connection with financing arrangements or
assignments of
Landlord's interest in the Premises or in conjunction with any administrative or judicial proceeding in which Landlord is involved and where Landlord is required to divulge such information. 

    20.15.  Costs and Attorneys' Fees. In the event of litigation between the parties hereto, declaratory or
otherwise to enforce this Lease, the non-prevailing party shall pay the costs thereof and attorneys' fees actually incurred by the prevailing party, in such suit, at trial and on appeal.
In addition, if Landlord engages counsel to enforce the terms of this Lease, including without limitation, for the purpose of preparing a delinquency notice, Tenant shall be required to reimburse
Landlord for all costs incurred before the subject default is considered cured. 

27

 

    20.16.  No Reservation or Option. The submission of this Lease for examination, or for execution by
Tenant, does not constitute a reservation or option to lease the Premises and this Lease becomes effective as a lease only upon execution and delivery thereof by Landlord and Tenant. 

    20.17.  Prior Understandings. Tenant acknowledges that neither Landlord nor anyone representing Landlord
has made statements of any kind whatsoever on which Tenant has relied in entering into this Lease including, without limitation, statements to the effect that any number of Tenants or any specific
Tenant or Tenants will operate in the Building during the Lease Term. Tenant further acknowledges that Tenant has relied solely on its independent investigation and its own business judgment in
entering into this Lease. Landlord and Tenant agree that: this Lease supersedes all prior and contemporaneous understandings and agreement; the provisions of this Lease are intended by them as the
final expression of their agreement; this Lease constitutes the complete and exclusive statement of its terms; and no extrinsic evidence whatsoever may be introduced in any judicial proceeding
involving this Lease. No provision of this Lease may be amended except by an agreement in writing signed by the parties hereto or their respective successors in interest, whether or not such amendment
is supported by new consideration. 

    20.18.  Authority. If Tenant is a corporation, each individual executing this Lease on behalf of said
corporation represents and warrants that he/she is duly authorized to execute and deliver this Lease on behalf of said corporation. Prior to, and as a condition of any draw by Tenant on the Allowance,
Tenant shall deliver to Landlord a certified copy of a resolution of the Board of Directors of said corporation ratifying the execution of this Lease. If Tenant is a partnership, each individual
executing this Lease on behalf of said partnership represents and warrants that he/she is duly authorized to execute and deliver this Lease on behalf of said partnership and that this Lease is binding
upon said partnership in accordance with its terms, and concurrently with execution of this Lease, Tenant shall deliver to Landlord such evidence of authorization as Landlord may require. If Tenant is
a marital community, or a member of a marital community, both members of the marital community shall execute this Lease. Where Tenant is comprised of more than one person or entity, all covenants,
agreements and
obligations of Tenant hereunder shall be the joint and several covenants, agreements and obligations of each person or entity comprising Tenant. Landlord represents and warrants to Tenant that as of
the date hereof, Landlord (and the person executing this Lease on behalf of Landlord) is authorized to execute this lease and Landlord owns and holds fee title in and to the Project. 

    20.19.  [intentionally omitted] 

    20.20.  Force Majeure. Time periods for Landlord's or Tenant's performance under any provisions of this
Lease (except for the payment of money) shall be extended for periods of time during which the non-performing party's performance is prevented due to circumstances beyond the party's
control, including, without limitation, strikes, embargoes, governmental regulations, inclement weather and other acts of God, war or other strife. 

    20.21.  Landlord Acting Through Agent. Any action permitted or required of Landlord under this Lease may,
at Landlord's election, be performed by Landlord's property manager on Landlord's behalf. 

    20.22.  Utility Deregulation. Tenant acknowledges that Landlord shall have sole control over the
determination of what utility providers serve the Project, and Landlord shall have no obligation to give access or easement rights or otherwise allow onto the Project any utility providers except
those approved by Landlord in its discretion. If, for any reason, Landlord permits Tenant to purchase utility services from a provider other than Landlord's designated company(ies), such provider
shall be considered a contractor of Tenant and Tenant shall indemnify defend and hold Landlord harmless from such provider's acts and omissions while in, or in connection with their services to, the
Building or Project in accordance with the terms and conditions of Section 12.1. In addition, Tenant shall allow Landlord to purchase such utility service from Tenant's provider at Tenant's
rate or at such lower rate as can be negotiated by the aggregation of Landlord's tenants' requirements for such utility. 

28

 

    20.23.  Clean Air Act. Tenant acknowledges that Landlord has not made any portion of the Premises or the
Building accessible for smoking in compliance with WAC 296-62-12000 and that no smoking is permitted in the Building. 

    20.24.  Landlord Knowledge. When the term "Landlord's knowledge" is used in this Lease, it shall mean the
specific knowledge of Michael S. Barnes of Barnes and Nelson Union Partners LLC. 

    20.25  Choice of Law and Venue. This Lease shall be governed by Washington law and the parties agree that
venue shall lie in King County, Washington. 

    20.26  Restriction on Leasing. Landlord shall not enter into any lease or occupancy agreement with a
party other than Tenant or Tenant's successor in interest with respect to any premises located in the Project that permits another party to use any portion of the Project for lifescience or
biotechnology purposes without Tenant's prior written consent which shall not be unreasonably withheld unless Tenant can show that the proposed is likely to limit or cross-contaminate Tenant's
operations. 

    20.27  Sales Tax Deferral. Portions of construction of the Tenant Improvements may be eligible for
deferral of state and local sales and use taxes pursuant to RCW Chapter 82.63 and WAC 458-20-24003 because Tenant will use the Premises for high technology research and
development. Promptly following execution of this Lease, and at the expense of the Tenant, Landlord and Tenant shall prepare and shall cooperate in processing an application with the Washington State
Department of Revenue for a deferral of state and local sales and use taxes with respect to the Tenant Improvements. Landlord and Tenant shall cooperate to prepare, at Tenant's expense, and each shall
execute any certificates or other documents required by the Department of Revenue to maintain the tax deferral. In that the sales tax deferral will flow directly through to Tenant in Tenant's ability
to purchase more with the $125 per square foot Allowance (and with any money in excess of that amount that Tenant contributes), Tenant will obtain the economic benefit of the sales tax deferral.
Tenant acknowledges that all or a portion of the deferred taxes may be required to be paid if the use of the Premises ceases to qualify for the tax deferral. In the event the state and local sales and
use taxes are deferred, and if for any reason, any part of the taxes so deferred is subsequently required to be paid, then Tenant shall promptly pay (if assessed against Tenant) and/or reimburse
Landlord (if assessed against Landlord) for the total amount of taxes that is required to be paid, together with any penalties, interest or other charges that are or become due in connection with such
taxes. Tenant shall indemnify, defend and hold harmless Landlord from any and all costs, expenses and claims arising out of or related to any deferral of state and local sales and use taxes for the
Tenant Improvements. 

21.  GENERATOR  

    The Premises shall include an electrical generator pad pursuant to the additional terms outlined on Exhibit L hereto (the "Generator Pad"). The
Generator Pad shall be constructed by Tenant in accordance with plans approved in advance by Landlord, which plans shall include fencing and such curbing as is necessary to contain any fuel spill.
Tenant may install on the Generator Pad a backup generator and fuel tank (collectively the "Generator"), the make, model and design of which shall be subject to Landlord's prior approval, which shall
not be unreasonably withheld. The design and operation of the Generator and Generator Pad shall be such as to avoid material interference with other tenants (whether due to vibration, noise, fumes, or
otherwise) resulting from operation of the
Generator. The Generator shall be used only for periodic testing and in the event Tenant's primary electrical service is involuntarily interrupted. All testing shall take place at times reasonably
selected to minimize interference with other tenants. The Generator shall be used only for backup power, and may not be used as a primary power source, nor may it be used by any occupant of any other
premises. The Generator Pad and the Generator shall be subject to all terms and conditions of the Lease, including but not limited to Sections 6, 9 and 12, provided only that the square footage of the
Generator Pad shall not be utilized in calculating the Premises Rentable Square Footage for the purpose of calculating 

29

 

Base Rent or allocating Common Expenses between the Premises and any larger parcel. All costs of maintenance, repairs, upgrades, licenses or other expenses arising directly or proximately from the
Generator shall be borne by Tenant. Upon expiration or earlier termination of this Lease, Tenant shall remove all improvements and equipment from the Generator Pad and shall provide such studies or
other information as is necessary to demonstrate to Landlord's reasonable satisfaction that there has been no environmental contamination on the Generator Pad as a result of the storage and operation
of the generator and fuel tank thereon. At the election of Landlord, Tenant shall further remove the Generator Pad itself and shall restore the area to a clean, paved condition, Failure of Tenant to
remove all improvements and equipment from the Generator Pad and restore same to the extent directed by Landlord shall be deemed a holdover of the entire Premises until such removal is complete. 

22.  ROOFTOP ANTENNA AND HVAC  

    Landlord shall permit Tenant to install and maintain at Tenant's sole expense a satellite dish and related equipment ("Antenna") on the roof of the Building in
a location mutually acceptable to Landlord and Tenant and subject to strict compliance with all applicable governmental laws and regulations. Tenant shall at all times own the Antenna. Landlord makes
no warranties or representations to Tenant as to the permissibility of an Antenna on the Building under applicable rules, laws and regulations. Tenant shall be permitted to erect and maintain the
Antenna for a term which will expire on the expiration or earlier termination of this Lease. Tenant shall be required to obtain all governmental permits, consents or authorizations necessary for the
erection and operation of the Antenna. If installation of the Antenna requires any roof penetrations, Tenant shall use a contractor approved by Landlord and shall cause such work to be done in a
manner that will preserve any roof warranty held by Landlord. 

    Landlord
shall further permit Tenant to install and maintain on the roof of the Building at Tenant's sole expense HVAC equipment serving the Premises, the nature, design and
specifications of such equipment to be subject to Landlord's reasonable approval, and the location to be subject to Landlord's approval in its discretion. Tenant shall use a contractor approved by
Landlord and shall cause such work to be done in a manner that will preserve any roof warranty held by Landlord. 

    Tenant's
installation and use of the Antenna may not in any way materially interfere with the systems of the Building or the quiet enjoyment of other tenants of the Building. Tenant
acknowledges that other tenants of the Building have or will be installing antenna and related equipment on the roof of the Building and Tenant agrees to cooperate with such other tenants so as to
avoid interference among users. Upon the expiration or earlier termination of this Lease, Tenant, at its sole cost and expense, shall remove the Antenna and restore the Building to a condition
comparable to its condition immediately prior to the installation of the Antenna, ordinary wear and tear, and casualty damage not caused by Tenant, its agents, employees, contractors or invitees,
excepted. 

    All
insurance and indemnification obligations of Tenant shall apply to any rooftop installations made by Tenant and any activities of Tenant in relation thereto. 

30

 

    Tenant agrees to consider, in its sole discretion, requests by Landlord to use the roof for uses not inconsistent or potentially inconsistent with Tenant's uses of the roof and the
Building. 

	 	 	LANDLORD:
	

 	
 	

WCM 132-302, LLC

a Washington limited liability company
	

 	
 	

By:	
 	

Barnes & Nelson Union Partners, LLC

Its Manager
	

 	
 	

 	
 	

By:	
 	

/s/ MICHAEL S. BARNES   
 Michael S. Barnes
	

 	
 	

 	
 	

Its:	
 	

President
	

 	
 	
TENANT:
	

 	
 	

Seattle Genetics Inc.

a Delaware corporation
	

 	
 	

 	
 	

By:	
 	

/s/ H. PERRY FELL   
 H. Perry Fell, PhD., MBA
	

 	
 	

 	
 	

Its:	
 	

Chief Executive Officer

31

 

RIDER 1 

 
 

RENEWAL OPTION    
  

    A.  Provided that Tenant is not in default after receipt of notice any expiration of any applicable cure period at the time of exercise or at
commencement of the Extended Term (unless the default is cured within any applicable cure period) and provided that Tenant has not been in monetary default under
this Lease during the prior 12 months, regardless of whether that default was cured within the applicable cure period, then Tenant shall have two options to extend the Lease term each for
7 years (each an "Extended Term"). In order to exercise either option, Tenant shall provide written notice ("Notice of Exercise") to Landlord of its election no sooner than 12 months and
no later than 9 months before the end of the initial lease term or Extended Term as appropriate. The exercise of such option to extend shall be for the then entire Premises and shall be on the
same terms and conditions as set forth in the Lease except (a) the Base Rent shall be adjusted as set forth in Paragraph B below, and (b) there shall be no tenant improvement
allowance. The option provided in this Rider is personal to Tenant (except for successors qualifying under Section 14.5 of the Lease) and may not be exercised by any assignee or sublessee and
may not be exercised during any period that the entire Premises is subleased out by Tenant. Failure to exercise either option within the appropriate time periods shall conclusively void any remaining
options. Failure to exercise the first option shall automatically void the second option. 

    B.  If
Tenant exercises an extension right pursuant to Paragraph A above, the initial Base Rent and the periodic increases for the Extended Term shall be equal
to the market rent, based on a net rent format, for a 7-year term for comparable office, small animal (i.e. rats and mice and similar sized animals) vivarium and lifescience laboratory
space located in Bothell, Washington ("Fair Market Rent Schedule"), but not less than the immediately preceding Base Rent. For purposes of this Lease, the term "Fair Market Rent Schedule" is
understood to mean the rents which a landlord would receive annually by then renting the space in question assuming the landlord to be a prudent person willing to lease but being under no compulsion
to do so, assuming the tenant to be a prudent person willing to lease but under no compulsion to do so, and assuming a lease containing the same terms and provisions as those herein contained
(including the lack of any additional tenant improvement allowance). Fair Market Rent Schedule shall take into consideration all relevant factors including the condition of the space and other terms
and conditions of the Lease, provided that if Tenant, at Tenant's cost, makes improvements after the initial Tenant Improvement build out, Fair Market Rent shall be computed as though the initial
improvements had remained. Fair Market Rent Schedule shall include the Tenant Improvements funded initially by the Landlord, plus any and all additional capital improvements paid by Landlord, but
shall exclude any additional improvements funded solely by the Tenant. Tenant's estimation of the Fair Market Rent Schedule ("Tenant's Rent Schedule") shall be included with Tenant's option exercise
notice. If Tenant exercises the extension right, Landlord shall give Tenant notice of Landlord's estimation of the Fair Market Rent Schedule ("Landlord's Rent Schedule") within 15 days of
exercise by Tenant. If there is a disagreement on the Fair Market Rent Schedule, the parties shall promptly meet and negotiate in good faith to attempt to resolve their differences. If the differences
are not resolved at least 7 months before the end of the then existing term, either party may submit the matter to be decided by binding arbitration according to the following procedure. 

    C.  Landlord
and Tenant shall each select an MAI appraiser with at least ten years experience in the office/high-tech industrial market (including
laboratory space) in the Bothell/Canyon Park area. If the two MAI appraisers are unable to agree within ten days after their selection, they shall select a similarly qualified third MAI appraiser (the
"Neutral Appraiser"). Within twenty days after selection of the Neutral Appraiser, the three appraisers shall simultaneously exchange determinations of Fair Market Rent. If the lowest appraisal is not
less than ninety percent (90%) of the highest appraisal, then 

32

 

the three appraisals shall be averaged and the result shall be the Fair Market Rent. If the lowest appraisal is less than ninety percent (90%) of the highest appraisal, then the Fair Market Rent shall
be deemed the rent set forth in the appraisal submitted by an appraiser appointed by a party that is closest in dollar amount to the appraisal submitted by the Neutral Appraiser. Each party shall bear
the costs of their own appraiser and the parties shall split the costs of the Neutral Appraiser. 

33

QuickLinks

OFFICE LEASE

RENEWAL OPTION

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00020-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00020-of-00352.parquet"}]]