Document:

LOCK-UP
        AGREEMENT

      

      THIS
        LOCK-UP AGREEMENT (this “Agreement”)
        is
        made and entered into as of the 15th
        day of
        June, 2007, between West Coast Opportunity Fund, LLC, a California limited
        liability company (“WCOF”),
        and
        the individuals and entities that execute and deliver a Counterpart Signature
        Page hereof, each a shareholder of Tribeworks, Inc., a Delaware corporation
        (the
“Company”),
        and
        sometimes collectively referred to herein as the “Stockholders”
and
        each, a “Stockholder.”

      

      WHEREAS,
        the Company intends to enter into a Securities Purchase Agreement between
        the
        Company and WCOF, dated on the date hereof (the “Securities
        Purchase Agreement”)
        pursuant to which the execution and delivery of this Agreement is a condition
        precedent to the closing of the Securities
        Purchase Agreement;
        and

      

      WHEREAS,
        in order to facilitate the consummation of the transactions contemplated
        by the
        Securities Purchase Agreement and to provide for an orderly market for the
        Company’s common stock, par value $0.0004 per share (the “Common
        Stock”),
        subsequent to the closing of the Securities Purchase Agreement, the Stockholders
        have agreed to enter into this Agreement and to restrict the sale, assignment,
        transfer, conveyance, hypothecation or alienation of the Common Stock, all
        on
        the terms set forth below.

      

      NOW,
        THEREFORE, in consideration of the foregoing premises and the mutual covenants
        contained herein, the receipt and sufficiency of which are hereby acknowledged,
        the parties hereto agree as follows:

      

      1.  Notwithstanding
        anything contained in this Agreement, a Stockholder may transfer his/her/its
        shares of Common Stock to his/her/its affiliates, partners in a partnership,
        subsidiaries and trusts, or spouses and lineal descendants for estate planning
        purposes provided that the transferee (or the legal representative of the
        transferee) executes an agreement to be bound by all of the terms and conditions
        of this Agreement. 

      

      2.  Each
        Stockholder agrees that it will not make or cause any sale, except as described
        in Section
        1,
        above,
        of any Securities listed on Exhibit
        A
        hereto
        (which, as of the date of this Agreement, the Stockholder owns of record),
        without WCOF’s prior written consent earlier than the ninetieth day following
        the date on which that certain Initial Promissory Note, dated as of the date
        hereof and executed by the Company in favor of WCOF and that certain Secondary
        Promissory Note, dated as of July 10, 2007, have been fully repaid or otherwise
        satisfied.

      

      3.  a.
        In
        the
        event
        of a firmly-underwritten public offering of Common Stock or other equity
        interest of the Company for the account of the Company registered under the
        Securities Act of 1933 (the “1933
        Act”)
        by a
        nationally recognized investment bank resulting in at least US $35,000,000
        in gross proceeds (before underwriters’ discounts and selling commissions) to
        the Company (the “Public
        Offering”),
        Stockholder agrees that for a period of six (6) months commencing on the
        effective date of the registration statement filed under the 1933 Act relating
        to the Public Offering (the “Lock-up
        Period”),
        Stockholder will not offer, sell, contract to sell, grant any option for
        the
        sale of, or otherwise dispose of, directly or indirectly, any of the Common
        Stock, or any other securities of the Company which are exercisable for any
        other securities of the Company. In order to enable the Company to enforce
        the
        aforesaid restrictions on transfer, Stockholder hereby agrees that the Company
        may impose stop-transfer instructions with respect to the securities of the
        Company owned beneficially or of record by Stockholder until the end of such
        six-month period.

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      b. In
        the
        event that the National Association of Securities Dealers, any other state
        or
        federal regulatory authority requires that the Lock-Up Period be extended
        in
        connection with the Public Offering, Stockholder agrees that it will use
        commercially reasonable efforts to execute any agreements and other documents
        to
        extend the Lock-Up Period to the extent required by the National Association
        of
        Securities Dealers or such regulatory authority. 

       

      c. Any
        one
        or more of the restrictions set forth in this Section
        3:
        (i) may
        be waived by the board of directors of the Company if it determines in good
        faith and in the exercise of its fiduciary duties that such waiver would
        be in
        the best interests of the Company and its stockholders for any valid business
        purpose, including, without limitation, to increase the liquidity of the
        Common
        Stock; and (ii) will be null and void upon the consummation of any tender
        offer
        to purchase all or substantially all of the Company’s issued and outstanding
        securities or any merger, consolidation or other reorganization of the Company
        with or into an unaffiliated Person if such transaction is approved by the
        affirmative vote of the requisite number of record and beneficial owners
        of the
        Company’s then outstanding and entitled to vote on such
        transaction.

       

      4. To
        the
        extent not inconsistent with applicable law, if Stockholder’s Common Stock are
        included in a registration statement, Stockholder agrees not to effect any
        public sale or distribution of the issue being registered or a similar security
        of the Company, or any securities exercisable for such securities, including
        a
        sale pursuant to Rule 144 under the 1933 Act, during the fourteen (14) days
        prior to, and during the one hundred eighty (180) day period beginning on,
        the
        effective date of such registration statement (except as part of the
        registration), if and to the extent requested by the managing underwriter
        or
        underwriters in the case of an underwritten public offering.

       

      5. By
        executing this Agreement, each Stockholder represents that the Common Stock
        set
        forth in Exhibit
        A
        is all
        of the shares of Company Common Stock that such Stockholder beneficially
        owns as
        of the date hereof. 

      

      6. In
        the
        event of a tender offer to purchase all or substantially all of Company’s issued
        and outstanding securities including all of the securities owned by WCOF,
        or a
        merger, consolidation or other reorganization with or into an unaffiliated
        entity, and if the requisite number of the record and beneficial owners of
        Company securities then outstanding are voted in favor of such tender offer,
        merger, consolidation or reorganization, and such tender offer, merger,
        consolidation or reorganization is completed, this Agreement shall terminate
        as
        of the closing of such event provided that the Promissory Note has been fully
        repaid or otherwise satisfied, and the Common Stock restricted pursuant hereto
        shall be immediately released from the restrictions contained
        herein.

      

      
        
           

        

        
          2

          
            

          

        

        
           

        

      

      7. Except
        as
        otherwise provided in this Agreement or any other agreements between the
        parties, the Stockholders shall be entitled to their respective beneficial
        rights of ownership of the Common Stock, including the right to vote the
        Common
        Stock for any and all purposes.

      

      8. The
        Common Stock restrictions covered by this Agreement shall be appropriately
        adjusted should the Company make a dividend or distribution, undergo a forward
        split or a reverse split or otherwise reclassify its shares of Common
        Stock.

      

      9. This
        Agreement may be executed in any number of counterparts with the same force
        and
        effect as if all parties had executed the same document.

      

      10. All
        notices, instructions or other communications required or permitted to be
        given
        pursuant to this Agreement shall be given in writing and delivered by certified
        mail, return receipt requested, overnight delivery or hand-delivered to all
        parties to this Agreement, to WCOF, at 2151 Alessandro Drive, Suite 100,
        Ventura, CA 93001, Attn: Atticus Lowe, CFA, and to the Stockholders, at the
        addresses in their Counterpart Signature Pages. All notices shall be deemed
        to
        be given on the same day if delivered by hand or on the following business
        day
        if sent by overnight delivery or the second business day following the date
        of
        mailing. 

      

      11. The
        sale
        and transfer restrictions on the Common Stock set forth in this Agreement
        shall
        be in addition to all other restrictions on transfer imposed by applicable
        United States and state securities laws, rules and regulations.

      

      12. This
        Agreement sets forth the entire understanding of the parties hereto with
        respect
        to the subject matter hereof, and may not be amended except by a written
        instrument executed by the parties hereto.

      

      13. This
        Agreement shall be governed by and construed in accordance with the laws
        of the
        State of Delaware applicable to contracts entered into and to be performed
        wholly within said State; and Company and the Stockholders agree that any
        action
        based upon this Agreement may be brought in the United States and state courts
        of Texas only, and each submits himself/herself/itself to the jurisdiction
        of
        such courts for all purposes hereunder.

      

      14. In
        the
        event of default hereunder, the non-defaulting parties shall be entitled
        to
        recover reasonable attorney’s fees incurred in the enforcement of this
        Agreement.

      

      
        
           

        

        
          3

          
            

          

        

        
           

        

      

      

      IN
        WITNESS WHEREOF, the undersigned have duly executed and delivered this Agreement
        as of the day and year first above written.

      

      
        	 	 	 
	 	WEST
                COAST
                OPPORTUNITY FUND, LLC
	 
 	 
 	 
 
	 	By:  	 
	 	
                
Name:
                Atticus Lowe
	 	Title: 
Chief
                Investment Officer

      

       

       

      
        
           

        

        
          
            [Signature
              Page to Lock-Up Agreement]

          

          
            

          

        

        
           

        

      

      

      Counterpart
        Signature Page to the Lock-Up Agreement

      

      IN
        WITNESS WHEREOF, the undersigned have duly executed and delivered this Lock-Up
        Agreement as of the day and year first above written.

      

      
        
          	 	 	 
	 	STOCKHOLDER:
	 
 	 
 	 
 
	 	By:	 
	 	 	
                  

                
	 	Name:	 
	 	 	
                  

                
	 	Address:	 
	 	
                  
                    

                  

                   

                  
                    

                  

                

        

       

      

      
        
           

        

        
          
            [Signature
              Page to Lock-Up Agreement]

          

          
            

          

        

        
           

        

      

       

      EXHIBIT
        A

      

      

      
        	
                Stockholder

              	
                Number
                  of Shares of Common Stock OwnedExhibit
      10.1

    

     

    EMPLOYMENT
      AGREEMENT EXTENSION

    

    Reference
      is made to the Employment Agreement (the “Agreement”), dated as of July 21,
      2004, by and between Ziopharm, Inc., a Delaware corporation and the predecessor
      to ZIOPHARM Oncology, Inc., a Delaware corporation (the “Company”), and RICHARD
      BAGLEY (the “Employee”). All terms used, but not otherwise defined herein, shall
      have the meanings assigned to them in the Agreement.

    

    Each
      of
      the Board, the Company and the Employee hereby consent and agree as
      follows:

    

    
      	
            	1.	
              Pursuant
                to Section 2 of the Agreement, the Term is extended for an additional
                one
                (1) year period.

            

    

    

    
      	
            	2.	
              The
                first sentence of Section 4(a) of the Agreement is hereby amended
                and
                restated in its entirety, as follows: “The Company shall pay Employee a
                salary (the “Base Salary”) equal to Two Hundred Seventy-Five Thousand
                Dollars ($275,000) per year.”

            

    

     

    Except
      for the extension of the Term and the amendment to Section 4(a) of the Agreement
      provided above, the terms and conditions of the Agreement remain applicable
      in
      their entirety.

    

    IN
      WITNESS WHEREOF, the Company and the Board have caused their respective duly
      authorized officer and representative to execute and the Employee has personally
      set his hand hereto as of the date set forth below.

     

    
      	 	 	 
	 	
              ZIOPHARM
                Oncology, Inc. and

              Its
                Board of Directors

            
	 
 	 
 	 
 
	 	By:  	 /s/
              Jonathan Lewis
	 	
              
Name:
              Jonathan Lewis, M.D.
	 	Title:
              Chief
              Executive Officer

    

     

    
      	 	 	 
	 	EMPLOYEE
	 
 	 
 	 
 
	 	By:  	 /s/
              Richard Bagley
	 	
              
Name: Richard
              Bagley

    

     

    
      	
              Dated:

            	June
              18, 2007

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