Document:

EXEL 2015.06.30 Exhibit 4.3

Exhibit 4.3
AMENDED AND RESTATED SECURED CONVERTIBLE NOTE
THIS NOTE IS ISSUED WITH ORIGINAL ISSUE DISCOUNT (“OID”) FOR U.S. FEDERAL INCOME TAX PURPOSES. THE ISSUE PRICE, AMOUNT OF OID, ISSUE DATE AND YIELD TO MATURITY WITH RESPECT TO THIS NOTE MAY BE OBTAINED BY WRITING TO THE BORROWER AT THE FOLLOWING ADDRESS: 210 EAST GRAND AVE., SOUTH SAN FRANCISCO, CALIFORNIA 94080; ATTN: EXECUTIVE VICE PRESIDENT AND GENERAL COUNSEL; FAX NUMBER:  (650) 837-7951.
.
July 1, 2015
FOR VALUE RECEIVED, EXELIXIS, INC., a Delaware corporation (the “Issuer”), by means of this Amended and Restated Secured Convertible Note (this “Note”), hereby unconditionally promises to pay to Deerfield International Master Fund, L.P. (the “Holder”), a principal amount equal to Fifty-Six Million Dollars ($56,000,000) (or such lesser amount as may be outstanding under this Note as result of prepayments and conversions by the Borrower pursuant to the Note Purchase Agreement (as defined below)), in lawful money of the United States of America and in immediately available funds, on the dates provided in the Note Purchase Agreement.
This Note is a “Note” referred to in the Note Purchase Agreement dated as of June 2, 2010 among the Issuer, the Holder and the other parties thereto (as amended, restated, supplemented or otherwise modified from time to time, the “Note Purchase Agreement”), with respect to the purchase of this Note by the Holder thereunder.  Capitalized terms used herein and not expressly defined in this Note shall have the respective meanings assigned to them in the Note Purchase Agreement.  All Obligations of the Issuer under this Note are secured as provided in the Security Agreement.
This Note shall bear interest on the Principal Amount hereof in the amounts set forth in and pursuant to the provisions of the Note Purchase Agreement.  This Note is subject to the voluntary and mandatory prepayment provisions set forth in the Note Purchase Agreement.
The Issuer shall make all payments to the Holder of interest and principal under this Note in the manner provided in and otherwise in accordance with the Note Purchase Agreement.  The principal amount of this Note may be converted into shares of Common Stock as set forth in the Note Purchase Agreement.  On July 1, 2018 and on any Major Transaction Put Date, the Principal Amount of this Note shall become due and payable.
If default is made in the punctual payment of principal or any other amount under this Note in accordance with the Note Purchase Agreement, or if any other Event of Default has occurred, this Note shall, at the Holder’s option exercised at any time upon or after the occurrence of any such payment default or other Event of Default and in accordance with the applicable provisions of the Note Purchase Agreement, become immediately due and payable.
All payments of any kind due to the Holder from the Issuer pursuant to this Note shall be made in the full face amount thereof, other than Excluded Taxes and Taxes for which the Holder (as a “Purchaser”) is responsible for pursuant to Section 2.5(b) of the Note Purchase Agreement.  The Issuer shall pay all and any costs (administrative or otherwise) imposed by banks, clearing houses, or any other financial institution, in connection with making any payments hereunder, except for any costs imposed by the Holder’s banking institutions.
The Issuer shall pay all reasonable costs of collection, including, without limitation, all reasonable, documented legal expenses and attorneys’ fees, paid or incurred by the Holder in collecting and enforcing this Note.
The Issuer and every endorser of this Note, or the obligations represented hereby, expressly waives presentment, protest, demand, notice of dishonor or default, and notice of any kind with respect to this Note and the Note Purchase Agreement or the performance of the obligations under this Note and/or the Note Purchase Agreement.  No renewal or extension of this Note or the Note Purchase Agreement, no release of any Person primarily or secondarily liable on this Note or the Note Purchase Agreement, including the Issuer and any endorser, no delay in the enforcement of 

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payment of this Note or the Note Purchase Agreement, and no delay or omission in exercising any right or power under this Note or the Note Purchase Agreement shall affect the liability of the Issuer or any endorser of this Note.
No delay or omission by the Holder in exercising any power or right hereunder shall impair such right or power or be construed to be a waiver of any default, nor shall any single or partial exercise of any power or right hereunder preclude the full exercise thereof or the exercise of any other power or right.  The provisions of this Note may be waived or amended only in a writing signed by the Issuer and the Holder.  This Note may be prepaid in whole or in part without premium or penalty, including in shares of Common Stock in accordance with the provisions of the Note Purchase Agreement.
THIS NOTE, AND ANY RIGHTS OF THE HOLDER ARISING OUT OF OR RELATING TO THIS NOTE, MAY, AT THE OPTION OF THE HOLDER, BE ENFORCED BY THE HOLDER IN THE COURTS OF THE UNITED STATES OF AMERICA LOCATED IN THE SOUTHERN DISTRICT OF THE STATE OF NEW YORK OR IN ANY OTHER COURTS HAVING JURISDICTION.  FOR THE BENEFIT OF THE HOLDER, THE ISSUER HEREBY IRREVOCABLY AGREES THAT ANY LEGAL ACTION, SUIT OR OTHER PROCEEDING ARISING OUT OF OR RELATING TO THIS NOTE MAY BE BROUGHT IN THE COURTS OF THE STATE OF NEW YORK OR OF THE UNITED STATES OF AMERICA FOR THE SOUTHERN DISTRICT OF NEW YORK, AND HEREBY CONSENTS THAT PERSONAL SERVICE OF SUMMONS OR OTHER LEGAL PROCESS MAY BE MADE AS SET FORTH IN SECTION 6.1 OF THE NOTE PURCHASE AGREEMENT, WHICH SERVICE THE ISSUER AGREES SHALL BE SUFFICIENT AND VALID.  THE ISSUER HEREBY WAIVES ANY AND ALL RIGHTS TO DEMAND A TRIAL BY JURY IN ANY ACTION, SUIT OR OTHER PROCEEDING ARISING OUT OF OR RELATING TO THIS NOTE OR THE TRANSACTIONS CONTEMPLATED BY THIS NOTE.
This Note shall be governed by, and construed in accordance with, the laws of the State of New York applicable to contracts made and to be performed in such State, without giving effect to the conflicts of laws principles thereof other than Sections 5-1401 and 5-1402 of the General Obligations Law of the State of New York.
Whenever this Note is held by a noteholder that is not a “United States person” within the meaning of Section 7701(a)(30) of the Internal Revenue Code of 1986, as amended (the “Code”), then it is the intention of the Issuer and such noteholder that (x) all interest accrued and paid on this Note will qualify for exemption from United States withholding tax as “portfolio interest” because this Note is an obligation which is in “registered form” within the meaning of Sections 871(h)(2)(B) and 881(c)(2)(B) of the Code and the applicable Treasury Regulations promulgated thereunder, and (y) as such, all interest accrued and paid on this Note will be exempt from United States information reporting under Sections 6041 and 6049 of the Code and United States backup withholding under Section 3406 of the Code.  The Issuer and the Holder shall reasonably cooperate with one another, and execute and file such forms or other documents, or do or refrain from doing such other acts, as may be required, to secure such exemptions from United States withholding tax, information reporting, and backup withholding.  In furtherance of the foregoing, any Holder, transferee or assignee noteholder that is not a United States person shall represent, warrant and covenant to the Issuer that (i) such noteholder is not, and will not be as long as any amounts due under this Note have not been paid in full, a “United States person,” within the meaning of Section 7701(a)(30) of the Code; (ii) such noteholder is not, and will not be as long as any amounts due under this Note have not been paid in full, a person described in Section 881(c)(3) of the Code; (iii) on or prior to the date of transfer or assignment (and on or prior to the date the form provided pursuant to this clause (iii) is no longer valid) until all amounts due under this Note have been paid in full, such noteholder shall provide the Issuer with a properly executed U.S. Internal Revenue Service (“IRS”) Form W-8BEN, Certificate of Foreign Status of Beneficial Owner for United States Tax Withholding (or any successor form prescribed by the IRS), certifying as to such noteholder’s status for purposes of determining exemption from United States withholding tax, information reporting and backup withholding with respect to all payments to be made to such noteholder hereunder; (iv) if an event occurs that would require a change in the exempt status of such noteholder or any of the other information provided on the most recent IRS Form W-8BEN (or successor form) previously submitted by such noteholder to the Issuer, such noteholder will so inform the Issuer in writing (or by submitting to the Issuer a new IRS Form W-8BEN or successor form) within 30 days after the occurrence of such event; and (v) such noteholder will not assign or otherwise transfer this Note or any of its rights hereunder except in accordance with the provisions hereof.  In the case of a Holder that is not a United States person and that, for U.S. federal income tax purposes, is treated as (A) a partnership (i) the representations, warranties and covenants set forth in the preceding sentence shall apply to such Holder and the Holder’s partners or members that are the beneficial owners of this Note for U.S. federal income tax purposes and are not United 

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States persons, and (ii) such Holder shall provide the Issuer with an IRS Form W-8IMY along with an IRS Form W-8BEN for each of such Holder’s partners or members (or an IRS Form W-8IMY with applicable IRS W-8BEN forms for such Holder’s partners or members) or (B) a disregarded entity, the representations, warranties and covenants set forth in the preceding sentence shall apply to such Holder’s beneficial owner.  A Holder that is not a United States person and that is treated as a partnership or disregarded entity for U.S. federal income tax purposes shall, in lieu of an IRS Form W-8, provide IRS Form W-9 certifying exemption from U.S. backup withholding with respect to any of such Holder’s partners or members that are United States persons.
In order to qualify as a “registered note” for purposes of the Code, transfer of this Note may be effected only by (i) surrender of this Note to the Issuer and the re-issuance of this Note to the transferee, or the Issuer’s issuance to the Holder of a new note in the same form as this Note but with the transferee denoted as the Holder, or (ii) the recording of the identity of the transferee by the Affiliate of the Holder that is maintaining a record ownership register of this Note as agent to, and on behalf of, the Issuer.  Such Affiliate in its capacity as such agent shall notify the Issuer in writing immediately upon any change in such identity.  The terms and conditions of this Note shall be binding upon and inure to the benefit of the Issuer and the Holder and their permitted assigns; provided, however, that if any such assignment (whether by operation of law, by way of transfer or participation, or otherwise) is to any noteholder that is not a “United States person” within the meaning of Section 7701(a)(30) of the Code, then such noteholder shall submit to the Issuer on or before the date of such assignment an IRS Form W-8BEN (or any successor form) certifying as to such noteholder’s status for purposes of determining exemption from United States withholding tax, information reporting and backup withholding with respect to all payments to be made to such noteholder under the new note (or other instrument).  Any attempted transfer in violation of the relevant provisions of this Note shall be void and of no force and effect.  Until there has been a valid transfer of this Note and of all of the rights hereunder by the Holder in accordance with this Note, the Issuer shall deem and treat the Holder as the absolute beneficial owner and holder of this Note and of all of the rights hereunder for all purposes (including, without limitation, for the purpose of receiving all payments to be made under this Note).
It is the intention of the Issuer and the Holder that this Note is to be a registered instrument and not a bearer instrument and the provisions of this Note are to be interpreted accordingly.  This Note is intended to be registered as to both principal and interest and all payments hereunder shall be made to the named Holder or, in the event of a transfer pursuant to the Note Purchase Agreement and this Note, to the transferee identified in the record of ownership of this Note maintained by the Holder on behalf of the Issuer.  Transfer of this Note may not be effected except in accordance with the provisions hereof.
This Note constitutes a renewal and restatement of, and replacement and substitution for, (i) a portion equal to $21,448,000 principal amount of that certain Secured Convertible Note dated as of July 2, 2010 in the original principal amount of $47,492,000 executed by Issuer in favor of Holder, as Assignee of Deerfield Private Design Fund, L.P. and (ii) a portion equal to $34,552,000 principal amount of that certain Secured Convertible Note dated as of July 2, 2010 in the original principal amount of $76,508,000 executed by Issuer in favor of Holder, as Assignee of Deerfield Private Design International, L.P. (collectively, the “Prior Notes”).  The indebtedness evidenced by the Prior Notes is continuing indebtedness evidenced hereby and nothing herein shall be deemed to constitute payment, settlement or novation of the Prior Notes or to release or otherwise adversely affect any Lien securing such indebtedness.
[Signature Page Follows]

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IN WITNESS WHEREOF, an authorized representative of the Issuer has executed this Note as of the date first written above.
	
	
	EXELIXIS, INC.
By:   /s/ Michael M. Morrissey   
Name:   Michael M. Morrissey, Ph.D.
Title:   President and Chief Executive Officer

4EXEL 2015.06.30 Exhibit 10.1

Exhibit 10.1
PARTIAL LEASE TERMINATION AGREEMENT
THIS PARTIAL LEASE TERMINATION AGREEMENT (this “Agreement”) is entered into as of June 30, 2015, by and between BRITANNIA POINTE GRAND LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”), and EXELIXIS, INC., a Delaware corporation (“Tenant”). 
RECITALS:
A.    Landlord and Tenant (formerly known as Exelixis Pharmaceuticals, Inc.) are parties to the Build-to-Suit Lease (“Original Lease”) dated May 12, 1999, whereby Tenant currently leases approximately 119,000 rentable square feet of space ("RSF") (the “Premises”) comprised of (i) the building located at 169 Harbor Way, South San Francisco, California (the "169 Building") containing approximately 49,000 RSF (referred to in the First Amendment as "Building 2"), and (ii) the building located at 170 Harbor Way, South San Francisco, California (the "170 Building") containing approximately 70,000 RSF (referred to in the First Amendment as "Building 1").  The Original Lease, as amended by (i) the First Amendment to Build-to-Suite Lease dated March 29, 2000, (ii) the Second Amendment to Build-to-Suite Lease dated January 31, 2001, and (iii) the Third Amendment to Build-to-Suite Lease dated May 24, 2001, is referred to herein as the "Lease".
B.    Tenant and Landlord desire to enter into this Agreement in order to terminate Tenant's lease of the 169 Building, and to release one another from their respective obligations thereunder, except as otherwise provided herein.
AGREEMENT:
NOW, THEREFORE, in consideration of the foregoing recitals and the conditions and the covenants hereinafter contained, and for other consideration hereinafter set forth, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows.
1.    EFFECTIVENESS OF THIS LEASE TERMINATION AGREEMENT.  Landlord and Tenant hereby acknowledge and agree that, notwithstanding the full execution and delivery of this Agreement by Landlord and Tenant, this Agreement is expressly conditioned upon the full execution and delivery of a lease amendment (the “Alios Expansion Amendment”) by Landlord and Alios Biopharma, Inc., a Delaware corporation ("Alios") (the terms and conditions of which Alios Expansion Amendment shall be acceptable to Landlord in its sole and absolute discretion) expanding Alios' existing lease with Landlord to include the 169 Building following the “Termination Date,” as defined below (the “Condition Precedent”).  Landlord shall have no liability whatsoever to Tenant relating to or arising from Landlord’s inability or failure to cause all or any portion of the Condition Precedent to be satisfied.  The Lease shall remain unmodified and in full force and effect unless and until such time as the Condition Precedent is satisfied.
2.    TERMINATION OF THE LEASE.  Landlord and Tenant hereby agree that, subject to the terms and conditions of Section 1 above, and conditioned upon the performance by the parties of the provisions of this Agreement, the Lease shall terminate and be of no further force or effect with respect to the 169 Building as of the date (the “Termination Date”), that is the later of (i) June 30, 2015, and (ii) the date that Tenant has completed the Decommissioning Process, as defined in Section 3, below.  Effective as of the date of this Agreement, all rights of Tenant (if any) to renew or extend the Term (including without limitation, as set forth in Section 2.6 of the Original Lease), and any right or option to lease additional space, or right or option to purchase, are hereby terminated and are of no further force or effect. 
3.    SURRENDER OF PREMISES.  Tenant hereby agrees to vacate the Premises and surrender and deliver exclusive possession of the Premises to Landlord on or before the Termination Date in accordance with the provisions of the Lease; provided that, notwithstanding anything to the contrary contained in the Lease:  (i) Landlord hereby agrees that there are no alterations, additions or improvements (collectively “Alterations”)  which Landlord will require Tenant to remove: (ii) Landlord acknowledges that Alios has requested that Tenant leave in place all telephone, computer, data and other cabling and wiring, and to leave in place and sell to Alios the  personal property owned by Tenant and listed in the First Amendment to that certain Release Agreement between Tenant and Alios dated 

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May 21, 2015 (the “Sold FF&E”); and (iii) Landlord agrees that Tenant’s obligation to surrender the Premises with the HVAC in good working order shall be satisfied by paying to HCP the amount of $28,858.00 within forty-five (45) days of the date of this Agreement, which amount represents the cost of the work Landlord and Tenant agree Tenant is responsible for as reflected in the Western Allied bids attached hereto as Exhibit B.  On or before the Termination Date, Tenant shall, at Tenant’s sole cost and expense, remove or cause to be removed from the Premises any and all furniture and equipment (other than the Sold FF&E), free-standing cabinet work, and other articles of personal property owned by Tenant, and such similar articles of any other persons claiming under Tenant and deliver the Premises to Landlord in a broom-clean condition, and with the Decommissioning Process complete.  Tenant shall immediately repair at its own expense all damage to the Premises and the Building resulting from any such removal.  If Tenant fails to complete such removal and/or repair any damage caused by such removal, Landlord may (but shall not be obligated to) do so and may charge the reasonable and actual cost thereof to Tenant.  Tenant will be required to close all applicable permits and licenses (including without limitation, any radiation license) and complete the decommissioning process for the 169 Building as certified by a qualified third party industrial hygienist, and receive written closure from the applicable governmental agencies as required by applicable laws (the "Decommissioning Process").
4.    ADJUSTMENT TO MONTHLY MINIMUM RENTAL AMOUNTS.  
4.1    Aggregate Monthly Minimum Rental.  Notwithstanding the termination of Tenant's lease of the 169 Building, the amount of Monthly Minimum Rental payable by Tenant under the Lease shall not be reduced, and, subject to the following terms of this Section 4, the amount of Monthly Minimum Rental that would have been payable for the 169 Building pursuant to the terms of the First Amendment, shall instead by payable for the 170 Building, and added to the amount of Monthly Minimum Rental otherwise payable for the 170 Building under the Original Lease (collectively, the "Aggregate Monthly Minimum Rental").  
4.2    Reduction of Aggregate Monthly Minimum Rental.  Upon the commencement of Alios' lease of the 169 Building pursuant to the Alios Expansion Amendment (the "Alios 169 Lease"), the Aggregate Monthly Minimum Rental payable by Tenant shall be reduced by an amount equal to the amounts payable by Alios to Landlord as "Minimum Rental" for the 169 Building under the Alios Expansion Amendment (the "Rental Adjustment(s)").  The Aggregate Monthly Minimum Rental, and the amounts of the Rental Adjustments, are set forth on Exhibit A attached hereto.
5.    OPERATING EXPENSES.  During the first two (2) months of the Alios 169 Lease, Alios will not be required to pay Operating Expenses with respect to the 169 Building (the "Operating Expense Abatement").  During such period, the Rental Adjustment shall be reduced by the amount of Operating Expenses that would otherwise have been paid by Alios, but for such Operating Expense Abatement.
6.    REPRESENTATIONS OF TENANT.  Tenant represents and warrants to Landlord that (a) Tenant has not heretofore assigned all or any portion of its interest in the Lease, and there are no subleases currently in effect with respect to the 169 Building; (b) no other person, firm or entity has any right, title or interest in the Lease with respect to the 169 Building; (c) Tenant has the full right, legal power and actual authority to enter into this Agreement and to terminate the Lease with respect to the 169 Building without the consent of any person, firm or entity; and (d) Tenant has the full right, legal power and actual authority to bind Tenant to the terms and conditions hereof. Tenant further represents and warrants to Landlord that as of the date hereof there are no, and as of the Termination Date there shall not be any, mechanic’s liens or other liens encumbering all or any portion of the 169 Building, by virtue of any act or omission on the part of Tenant, its predecessors, contractors, agents, employees, successors or assigns. Notwithstanding the termination of the Lease and the release of liability provided for herein, the representations and warranties set forth in this Section 5 shall survive the Termination Date and Tenant shall be liable to Landlord for any inaccuracy or any breach thereof.
7.    CONTINUING LIABILITY.  Notwithstanding the termination of the Lease and the release of liability provided for herein, except as expressly set forth in this Agreement, Tenant shall remain liable, with respect to the period of its tenancy prior to the Termination Date, for the performance of all of its obligations under the Lease (including, without limitation, Tenant’s payment of reconciliation of Operating Expenses) and Landlord shall have all the rights and remedies with respect to such obligations as set forth in the Lease.  In the event that Tenant retains 

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possession of the 169 Building or any part thereof after the Termination Date, then the provisions of Section 2.5 of the Original Lease shall apply.
8.    CONNECTOR BRIDGE.  The "Connector Bridge", as defined in Section 1(b) of the First Amendment shall be deemed to be a part of the 170 Building, and shall continue to be a part of the Premises leased by Tenant under the Lease, as amended hereby.  Landlord or Alios shall have the right to demise and secure the 169 Building so that there is no access from the Connector Bridge to the 169 Building.
9.    SECURITY DEPOSIT.  The Security Deposit held by Landlord with respect to the 169 Building, in the amount of $131,810.00, will be returned to Tenant (or, at Tenant's option, credited against other amounts owing from Tenant to Landlord under the Lease) promptly following the Termination Date.
10.    ATTORNEYS’ FEES.  Should any dispute arise between the parties hereto or their legal representatives, successors and assigns concerning any provision of this Agreement or the rights and duties of any person in relation thereto, the party prevailing in such dispute shall be entitled, in addition to such other relief that may be granted, to recover reasonable attorneys’ fees and legal costs in connection with such dispute.
11.    DISPOSITION OF PERSONAL PROPERTY.  Notwithstanding the above, Tenant shall continue to have access to the 169 Building through and including the Termination Date in order to remove all of its personal property, equipment and signage other than the Sold FF&E (“Personal Property”) from the Premises.   In the event that Tenant does not remove its Personal Property from the 169 Building prior to such Termination Date, Tenant acknowledges that Landlord shall be entitled, but shall not be obligated, to dispose of said Personal Property in any manner it deems fit, and charge the cost of such disposal to Tenant.  Tenant hereby waives any rights it may have to notice under California Civil Code sections 1980 et seq. with respect to such Personal Property.
12.    GOVERNING LAW.  This Agreement shall be governed and construed under the laws of the State of California.
13.    COUNTERPARTS.  This Agreement may be executed in counterparts, each of which shall be deemed an original, but such counterparts, when taken together, shall constitute one agreement.
14.    BINDING EFFECT.  This Agreement shall inure to the benefit of, and shall be binding upon, the parties hereto and their respective legal representatives, successors and assigns.
15.    TIME OF THE ESSENCE.  Time is of the essence of this Agreement and the provisions contained herein.
16.    FURTHER ASSURANCES.  Landlord and Tenant hereby agree to execute such further documents or instruments as may be necessary or appropriate to carry out the intention of this Agreement.
17.    VOLUNTARY AGREEMENT.  The parties have read this Agreement and mutual release as contained herein, and on the advice of counsel they have freely and voluntarily entered into this Agreement.
18.    DEFINED TERMS.  All terms defined in the Lease when used herein shall have the same meaning as is given such terms in the Lease unless expressly superseded by the terms of this Agreement.

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IN WITNESS WHEREOF, Landlord and Tenant have executed this Agreement as of the day and year first above written.  

“LANDLORD”
BRITANNIA POINTE GRAND 
LIMITED PARTNERSHIP,
a Delaware limited partnership
		
	By:
	HCP-Pointe Grand, Incorporated,  
a Delaware corporation, its general partner

By: /s/ Jonathan M. Bergschneider    
Jonathan M. Bergschneider,
Executive Vice President
“TENANT”
EXELIXIS, INC.,
a Delaware corporation
By: /s/ Deborah Burke    
Name: Deborah Burke    
Its: SVP & CFO    
By:    
Name:    
Its:    

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EXHIBIT A
AGGREGATE MONTHLY MINIMUM RENTAL  
AND REDUCTION AMOUNTS

Note that the foregoing dates and amounts may be subject to change if the Termination Date occurs after June 30, 2015.
*Subject to Section 5 of this Agreement.

Exhibit A
1

EXHIBIT B
[Bids attached]

Exhibit B
1

Exhibit B
2

Exhibit B
3

Exhibit B
4

Exhibit B
5

Exhibit B
6

Exhibit B
7

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