Document:

EX-10.37

 Exhibit 10.37 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE ROIVANT SCIENCES LTD. (THE “COMPANY”) HAS
DETERMINED THAT THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED. 
  

 
 LICENSE AND COLLABORATION
AGREEMENT 
 by and between 

PFIZER INC. 
 and

 PRIOVANT, INC. 

DATED AS OF SEPTEMBER 13, 2021 
  

 

 TABLE OF CONTENTS 

Page 
  

							
	 1. DEFINITIONS
	  	 	5	 
		
	 2. LICENSE GRANT
	  	 	19	 
			
	 2.1
	 	License Grant to Licensee	  	 	19	 
	 2.2
	 	Sublicense Rights	  	 	20	 
	 2.3
	 	License Grant to Pfizer	  	 	20	 
	 2.4
	 	Retained Rights	  	 	21	 
	 2.5
	 	Residuals	  	 	21	 
	 2.6
	 	No Additional Rights	  	 	21	 
		
	 3. CLOSING
	  	 	21	 
			
	 3.1
	 	Closing	  	 	21	 
	 3.2
	 	Closing Deliverables	  	 	21	 
		
	 4. TRANSFER ACTIVITIES
	  	 	22	 
		
	 5. DEVELOPMENT; REGULATORY; MANUFACTURING
	  	 	22	 
			
	 5.1
	 	General	  	 	22	 
	 5.2
	 	Alliance Management	  	 	22	 
	 5.3
	 	Diligence	  	 	22	 
	 5.4
	 	Regulatory Filings	  	 	23	 
	 5.5
	 	Progress Reporting	  	 	25	 
	 5.6
	 	Permitted Contractors	  	 	25	 
	 5.7
	 	Development Plan	  	 	25	 
	 5.8
	 	Safety Reporting	  	 	25	 
	 5.9
	 	Ongoing Clinical Trials	  	 	26	 
	 5.10
	 	[***]	  	 	26	 
	 5.11
	 	[***]	  	 	26	 
	 5.12
	 	Compliance	  	 	26	 
		
	 6. COMMERCIALIZATION
	  	 	27	 
			
	 6.1
	 	General	  	 	27	 
	 6.2
	 	Diligence	  	 	27	 
	 6.3
	 	[***]	  	 	27	 
	 6.4
	 	[***]	  	 	27	 
	 6.5
	 	Territory Integrity	  	 	27	 
	 6.6
	 	[***]	  	 	29	 
	 6.7
	 	Compliance	  	 	29	 

  
 1 

							
	 7. PAYMENT TERMS
	  	 	29	 
			
	 7.1
	 	Inventory Payment	  	 	29	 
	 7.2
	 	Sales Milestone Payments	  	 	29	 
	 7.3
	 	Royalty Payments	  	 	30	 
	 7.4
	 	Royalty Deduction	  	 	32	 
	 7.5
	 	Blended Royalty	  	 	33	 
	 7.6
	 	Other Payments	  	 	33	 
	 7.7
	 	Late Payments	  	 	33	 
	 7.8
	 	Currency	  	 	33	 
	 7.9
	 	Method of Payment	  	 	34	 
	 7.10
	 	Taxes	  	 	34	 
		
	 8. RECORDS; AUDIT RIGHTS
	  	 	36	 
			
	 8.1
	 	Relevant Records	  	 	36	 
	 8.2
	 	Audit Request	  	 	36	 
	 8.3
	 	Audit Fees and Expenses	  	 	36	 
	 8.4
	 	Payment of Deficiency	  	 	36	 
		
	 9. INTELLECTUAL PROPERTY RIGHTS.
	  	 	36	 
			
	 9.1
	 	Pre-existing IP	  	 	36	 
	 9.2
	 	Patent Prosecution	  	 	37	 
	 9.3
	 	Trademarks	  	 	39	 
		
	 10. INFRINGEMENT; MISAPPROPRIATION
	  	 	40	 
			
	 10.1
	 	Notification	  	 	40	 
	 10.2
	 	Infringement Action	  	 	40	 
		
	 11. CONFIDENTIALITY [***]
	  	 	41	 
			
	 11.1
	 	Obligations	  	 	41	 
	 11.2
	 	Exceptions	  	 	42	 
	 11.3
	 	Ongoing Obligation for Confidentiality	  	 	43	 
	 11.4
	 	[***]	  	 	43	 
		
	 12. REPRESENTATIONS, WARRANTIES AND COVENANTS
	  	 	43	 
			
	 12.1
	 	Representations and Warranties by Each Party	  	 	43	 
	 12.2
	 	Representations and Warranties and Covenants by Pfizer	  	 	44	 
	 12.3
	 	Representations, Warranties and Covenants by Licensee	  	 	44	 
	 12.4
	 	Representations, Warranties and Covenants Related to Anti-Corruption Laws and Healthcare Laws	  	 	44	 
	 12.5
	 	Representations, Warranties and Covenants Related to Global Trade Control Laws	  	 	44	 
	 12.6
	 	No Action Required Which Would Violate Law	  	 	44	 
	 12.7
	 	No Other Warranties	  	 	44	 
	 12.8
	 	Disclaimer	  	 	44	 
	 12.9
	 	Other Government Approvals	  	 	45	 

  
 2 

							
	 13. INDEMNIFICATION
	  	 	45	 
			
	 13.1
	 	Indemnification by Licensee	  	 	45	 
	 13.2
	 	Indemnification by Pfizer	  	 	45	 
	 13.3
	 	Indemnification Procedure for Third Party Claims	  	 	46	 
	 13.4
	 	Indemnification Procedure for Direct Claims	  	 	47	 
		
	 14. LIMITATION OF LIABILITY
	  	 	47	 
			
	 14.1
	 	Damages Waiver	  	 	47	 
	 14.2
	 	[***]	  	 	47	 
	 14.3
	 	[***]	  	 	47	 
	 14.4
	 	Survival	  	 	47	 
	 14.5
	 	Exclusive Remedy	  	 	48	 
	 14.6
	 	Insurance Recovery	  	 	48	 
	 14.7
	 	No Set-Off	  	 	48	 
		
	 15. TERM; TERMINATION
	  	 	48	 
			
	 15.1
	 	Term	  	 	48	 
	 15.2
	 	Termination for Cause	  	 	49	 
	 15.3
	 	[***]	  	 	49	 
	 15.4
	 	Effects of Termination	  	 	49	 
	 15.5
	 	Survival	  	 	58	 
	 15.6
	 	365(n) Rights	  	 	59	 
		
	 16. PUBLICITY; PUBLICATIONS
	  	 	59	 
			
	 16.1
	 	Use of Names	  	 	59	 
	 16.2
	 	Press Releases	  	 	59	 
	 16.3
	 	Publications	  	 	60	 
		
	 17. INSURANCE
	  	 	60	 
			
	 17.1
	 	Licensee Insurance Requirements	  	 	60	 
	 17.2
	 	Licensee Policy Notification	  	 	60	 
	 17.3
	 	Pfizer Insurance Requirements	  	 	61	 
	 17.4
	 	Pfizer Policy Notification	  	 	61	 
		
	 18. GENERAL PROVISIONS
	  	 	61	 
			
	 18.1
	 	Assignment	  	 	61	 
	 18.2
	 	Severability	  	 	62	 
	 18.3
	 	Governing Law; Dispute Resolution	  	 	62	 
	 18.4
	 	Equitable Relief	  	 	64	 
	 18.5
	 	Force Majeure	  	 	64	 
	 18.6
	 	Waivers and Amendments	  	 	65	 
	 18.7
	 	Relationship of the Parties	  	 	65	 
	 18.8
	 	Successors and Assigns	  	 	65	 
	 18.9
	 	Notices	  	 	65	 
	 18.10
	 	Further Assurances	  	 	66	 
	 18.11
	 	No Third Party Beneficiary Rights	  	 	66	 

  
 3 

							
	 18.12
	 	Entire Agreement; Confidentiality Agreement	  	 	66	 
	 18.13
	 	Counterparts	  	 	66	 
	 18.14
	 	Cumulative Remedies	  	 	67	 
	 18.15
	 	Performance by Affiliates	  	 	67	 
	 18.16
	 	Waiver of Rule of Construction	  	 	67	 

  
 4 

 LICENSE AND COLLABORATION AGREEMENT 

THIS LICENSE AND COLLABORATION AGREEMENT (“Agreement”) is dated as of the
13th day of September, 2021 (the “Effective Date”), by and between Pfizer Inc., a corporation organized and existing under the laws of Delaware with offices at [***]
(“Pfizer”), Priovant, Inc., a corporation organized and existing under the laws of Delaware with offices at [***] (“Licensee”), and solely with respect to Section 11.4, Roivant Sciences
Ltd., a corporation organized and existing under the laws of Bermuda with offices at [***] (“Roivant”). Licensee and Pfizer (and, solely with respect to Section 11.4, Roivant) may, from time-to-time, be individually referred to as a “Party” and collectively referred to as the “Parties”. 

RECITALS 
 WHEREAS, Pfizer
Controls the Licensed Technology (hereinafter defined); and 
 WHEREAS, Licensee wishes to obtain, and Pfizer wishes to grant, certain
licenses under the Licensed Technology on the terms and conditions set forth herein. 
 NOW, THEREFORE, in consideration of the mutual
agreements and covenants set forth herein and other good and valuable consideration, the receipt and sufficiency of which the Parties hereby acknowledge, the Parties, intending to be legally bound hereby, agree to the foregoing and as follows: 

 

	1.	 DEFINITIONS. 

1.1 “[***]” means [***]. 

1.2 “[***]” means [***]. 

1.3 “AAA” is defined in Section 18.3.3. 

1.4 “Accounting Standard” means International Financial Reporting Standards (IFRS) or U.S. Generally Accepted
Accounting Principles (GAAP), as generally and consistently applied by the applicable entity in accordance with Applicable Law. 

1.5 “Affiliate” means, with respect to a Party, as of the applicable point in time and for so long as the applicable
relationship exists, any Person that controls, is controlled by, or is under common control with that Party. For the purpose of this definition, the definition of Excluded Affiliate, and Sections 12.4 and 12.5, “control” and,
with correlative meanings, the terms “controlled by” and “under common control with” shall refer to: (a) the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of
an entity, whether through the ownership of voting securities or other ownership interest, by contract or otherwise, or (b) the ownership, directly or indirectly, of fifty percent (50%) or more of the voting securities or other ownership
interest of such entity (or, with respect to a limited partnership or other similar entity, its general partner or controlling entity). The Parties acknowledge that in the case of certain entities organized under the laws of certain countries
outside of the United States, the maximum percentage ownership permitted by law for a foreign investor may be less than fifty percent (50%), and that in such case such lower percentage shall be substituted in the preceding sentence, provided
that such foreign investor has the power to direct the management or policies of such entity. Notwithstanding the foregoing, an Excluded Affiliate will not be deemed an Affiliate of Licensee for any purpose under this Agreement. 

  
 5 

 1.6 “Agreement” is defined in the introduction to this Agreement.

 1.7 “Alliance Manager” is defined in Section 5.2.1. 

1.8 “Anti-Corruption Laws” means applicable international, national, state and local laws, statutes, rules and
regulations regarding corruption and bribery, including laws that prohibit the corrupt payment, offer, promise, or authorization of the payment or transfer of anything of value (including gifts or entertainment), directly or indirectly, to any
Government Official, commercial entity, or any other Person to obtain an improper business advantage, including the Foreign Corrupt Practices Act (15 U.S.C.
§78-dd-1, et seq.), the UK Bribery Act of 2010, and laws implementing the Convention on Combating Bribery of Foreign Public Officials in International Business
Transactions; each as may be amended or supplemented from time to time. 
 1.9 “Applicable Law” means any applicable
United States federal, state or local law, or foreign or multinational law, statute, standard, ordinance, code, rule, regulation, resolution, or promulgation, or any order, writ, judgment, injunction, decree, stipulation, ruling, determination, or
award entered by or with any Governmental Authority, or any license, franchise, permit, or similar right granted under any of the foregoing, or any similar provision having the force or effect of law, including the Federal Food, Drug, and Cosmetic
Act (21 U.S.C. § 301, et seq.), the Anti-Kickback Statute (42 U.S.C. § 1320a-7b), the Civil Monetary Penalty Statute (42 U.S.C. § 1320a-7a), the False
Claims Act (31 U.S.C. § 3729 et seq.), comparable state statutes, the regulations promulgated under all such statutes, and the regulations issued by the FDA, and all applicable Anti-Corruption Laws, accounting and recordkeeping laws, and laws
relating to interactions with Healthcare Professionals and Government Officials. For the avoidance of doubt, any specific references to any Applicable Law or any portion thereof shall be deemed to include all then-current amendments thereto or any
replacement or successor law, statute, standard, ordinance, code, rule, regulation, resolution, promulgation, order, writ, judgment, injunction, decree, stipulation, ruling, or determination thereto. 

1.10 “Bankruptcy Code” is defined in Section 15.6. 

1.11 “Brepo” is defined in Section 1.12. 

1.12 “Brepo Compounds” means brepocitinib [***] (“Brepo”), [***]. 

1.13 “Brepo Product” means [***]. 

1.14 “Business” is defined in Section 12.2.17. 

1.15 “Business Day” means any day other than a Saturday, a Sunday or a day on which commercial banks located in New
York, New York or London, United Kingdom are authorized or required by Applicable Law to remain closed. 

  
 6 

 1.16 “Calendar Quarter” means the respective periods of three
(3) consecutive calendar months ending on March 31, June 30, September 30 and December 31, except that the first Calendar Quarter of the Term commences on the Effective Date and ends on the first to occur of March 31,
June 30, September 30 and December 31 after the Effective Date, and the last Calendar Quarter of the Term ends on the last day of the Term. 

1.17 “Calendar Year” means the period of twelve (12) consecutive calendar months ending on December 31,
except that the first Calendar Quarter of the Term commences on the Effective Date and ends on December 31 of the year in which the Effective Date occurs, and the last Calendar Year of the Term commences on January 1 of the year in which
the Term ends and ends on the last day of the Term. 
 1.18 “Cap” means [***]. 

1.19 [***] 
 1.20
“CDA” means that certain Confidential Disclosure Agreement, dated [***], entered into between the Parties or any of their respective Affiliates. 

1.21 “Change of Control” means, with respect to a Party, whether effected in a single transaction or a series of
related transactions, [***]. 
 1.22 “Clinical Trial” means those studies in human subjects that are required by
Applicable Law, or otherwise recommended or required by the Regulatory Authorities or reasonably useful, to obtain or maintain any Regulatory Approval for a Product for one (1) or more indications. 

1.23 “Closing” is defined in Section 3.1. 

1.24 “CMO” means a contract manufacturing organization. 

1.25 “[***]” is defined in Section 6.3. 

1.26 “[***]” is defined in Section 6.3. 

1.27 “Code” means the U.S. Internal Revenue Code of 1986, as amended. 

1.28 [***] 
 1.29
“Commercialize” or “Commercialization” means to market, promote, distribute, offer for sale, sell, have sold, import, have imported, export, have exported or otherwise commercialize a compound or product. When used
as a noun, “Commercialization” means any and all activities involved in Commercializing. 
 1.30
“Commercially Reasonable Efforts” means, with respect to the Development or Commercialization of a Compound or Product in or for a particular country, [***]. 

1.31 “Compound Product” is defined in Section 1.97. 

  
 7 

 1.32 “Compounds” means Brepo Compounds and TYK2 Compounds. 

1.33 “Confidential Information” means the existence, terms and provisions of this Agreement and all other proprietary
information and data of a financial, commercial or technical nature that the disclosing Party or any of its Affiliates has supplied or otherwise made available to the other Party or its Affiliates. [***] Confidential Information shall not
include information that: (a) is, at the time of disclosure or becomes, after the time of disclosure, known to the public or part of the public domain through no breach of this Agreement by the receiving Party or any Recipients to whom it
disclosed such information; (b) was known to, or was otherwise in the possession of, the receiving Party prior to the time of disclosure by the disclosing Party to the receiving Party; (c) is disclosed to the receiving Party on a non-confidential basis by a Third Party who is entitled to disclose it without breaching any confidentiality obligation to the disclosing Party; or (d) is independently developed by or on behalf of the
receiving Party or any of its Affiliates, as evidenced by its written records, without use of or access to the Confidential Information. 

1.34 “Control” or “Controlled” means, with respect to any Intellectual Property Rights or other
rights to provide data or other information, the legal authority or right (whether by ownership, license or otherwise, other than any license granted pursuant to this Agreement) of a Party to grant a license or a sublicense of or under such
Intellectual Property Rights to the other Party or provide such data or other information to such other Party without breaching the terms of any agreement with a Third Party. 

1.35 “Covered” means, with respect to a given Compound or Product and a given Valid Claim of a Licensed Patent Right,
that the Exploitation of such Compound or Product would, but for the licenses granted by Pfizer to Licensee under this Agreement, infringe such Valid Claim. 

1.36 “CRO” means a contract research organization. 

1.37 “CSO” means a contract sales organization. 

1.38 [***]. 
 1.39
[***] 
 1.40 “Develop” or “Developing” means to discover, research or otherwise develop a process,
compound or product, including conducting non-clinical and clinical research and development activities directed to, necessary, reasonably useful or otherwise requested or required by a Regulatory Authority as
a condition or in support of obtaining or maintaining a Regulatory Approval, including fulfilling post-approval regulatory obligations. When used as a noun, “Development” means any and all activities involved in Developing. 

1.41 “Developed IP” means any Intellectual Property Rights that are: (a) both (i) related to the Compounds or
Products, and (ii) conceived or reduced to practice by Licensee, its Affiliates or sublicensees alone or together with one or more Third Parties during the Term in connection with the Development, Manufacture or use of any Compound or Product
under this Agreement or (b) both (i) related to the Compounds or Products, and (ii) Controlled by Licensee pursuant to a Licensee Third Party License. 

  
 8 

 1.42 “Development Plan” is defined in
Section 5.7. 
 1.43 “Effective Date” is defined in the introduction to this Agreement.

 1.44 “Election Notice” is defined in Section 9.2.4. 

1.45 “EMA” means the European Medicines Agency or any successor agency thereto. 

1.46 “E.U.” means any of the 27 countries comprising the European Union as of the Effective Date, and any additional
member countries from time to time, and the United Kingdom. 
 1.47 “Excluded Action” is defined in
Section 18.3.7. 
 1.48 “Excluded Affiliate” means [***]. For clarity, a Person may cease
to be or may become an Excluded Affiliate from time to time if its status changes such that it ceases to satisfy or satisfies the requirements of an Excluded Affiliate hereunder. 

1.49 “Existing Pfizer Affiliates” means the Affiliates of Pfizer existing as of the Effective Date. 

1.50 “Exploit” or “Exploitation” means to Develop, Manufacture or Commercialize, or to otherwise
make, use, offer to sell, sell or import, a compound or product. When used as a noun, “Exploitation” means any and all activities involved in Exploiting. 

1.51 “FD&C Act” means the United States Federal Food, Drug, and Cosmetic Act (21 U.S.C. §§ 301 et seq.),
as amended, and the rules and regulations promulgated thereunder. 
 1.52 “FDA” means the United States Food and
Drug Administration or any successor federal agency thereto. 
 1.53 “Fees” means (a) in the case of Pfizer,
collectively, the Inventory Payment and any and all U.S. Sales Milestone Payment and Licensee Royalties, and (b) in the case of Licensee, collectively, ROW Sales Milestone Payment and Pfizer Royalties. 

1.54 “Field” means the treatment, prevention, diagnosis, control and maintenance of all indications in humans and
animals. 
 1.55 “First Commercial Sale” means the first sale of a Product by Licensee or Licensee’s Affiliate
or sublicensee to a Third Party in a country in the Territory following receipt of Regulatory Approval for such Product in such country. Dispositions of Product, or use of Product in, clinical trials or other scientific testing, as free samples, or
under expanded access programs or for charitable purposes shall not be considered a First Commercial Sale. 
 1.56 “First
Reporting Window” is defined in Section 5.5.1. 
 1.57 “Fraud” means, with respect to
any Person, a deliberately fraudulent misrepresentation with respect to the making of the representations and warranties specifically set forth in Section 12, as applicable, with the actual knowledge by such Person that
such representations and warranties made pursuant to Section 12 (each as qualified by the Disclosure Schedules), as applicable, were untrue when made, with the specific intention that a Party to this Agreement rely thereon
to its detriment and such Party did in fact rely thereon to such Party’s detriment; provided, however, that in no event shall the knowledge of any Person be imputed to any other Person. 

  
 9 

 1.58 “FTE” means the efforts of one or more employees of Pfizer (or
its Affiliate) equivalent to the efforts of one full-time employee for one year, or in the case of less than a full-time dedicated person, a full-time equivalent person-year based upon a total of eighteen hundred (1800) hours per year of work.

 1.59 “Generic Competition” means, with respect to a Product (the “Reference Product”) in a
particular country in the Territory, [***]. 
 1.60 “Generic Product” means, with respect to the Reference Product
in a particular country in the Territory, any pharmaceutical product that (a) is marketed for sale by a Third Party not authorized by Licensee, (b) receives Regulatory Approval (with or without Pricing and Reimbursement Approval) in such
country in full or partial reliance on the Regulatory Approval (but not necessarily Pricing and Reimbursement Approval) of the Reference Product, and (c) is determined by a Regulatory Authority to be therapeutically equivalent (as defined in
FDA regulations at 21 CFR 314.3(b)) to and substitutable with the Reference Product, it being acknowledged that the foregoing standard is intended to be consistent with the standard set forth in the introduction to the “Orange Book,” as
amended from time to time, or any analogous or comparable standard in any country outside of the United States. For the avoidance of doubt, in the United States, a “Generic Product” as defined herein includes one approved under
Section 505(j) of the FD&C Act, as supplemented or amended. 
 1.61 “Global Regulatory Filings” means
[***]. 
 1.62 “Global Trade Control Laws” means the U.S. Export Administration Regulations; the U.S. International
Traffic in Arms Regulations; the U.S. economic sanctions rules and regulations implemented under statutory authority or the President’s Executive Orders and administered by the U.S. Department of the Treasury Office of Foreign Assets Control;
E.U. Council Regulations on export controls, including Nos. 428/2009, 267/2012; other E.U. Council sanctions regulations, as implemented in E.U. Member States; United Nations sanctions policies; all relevant regulations and legislative instruments
made under any of the above; other applicable economic sanctions, export and import control laws, and other applicable laws, regulations, legislation, Orders and requirements imposed by a relevant Governmental Authority. 

1.63 “GMP” means all applicable requirements, standards, practices, and procedures for current good manufacturing
practices for pharmaceuticals promulgated by FDA, including those included in the FD&C Act and 21 C.F.R. Parts 210, 211 and 820, as the same may be amended from time to time, and such standards of good manufacturing practice as are required by
the Regulatory Authorities of the E.U. and other organizations and Governmental Authorities in countries in which the applicable Product is intended to be manufactured or sold, to the extent such standards are not less stringent than United States
GMP. 

  
 10 

 1.64 “Good Clinical Practices” means the FDA’s standards for
the design, conduct, performance, monitoring, auditing, recording, analysis, and reporting of clinical trials contained in 21 C.F.R. Parts 50, 54, 56, 58 and 312, or those equivalent standards applicable in the relevant jurisdiction. 

1.65 “Government” or “Governmental Authority” is broadly interpreted and includes: (a) any
national, federal, state, local, regional, or foreign government, or level, branch, or subdivision thereof; (b) any multinational or public international organization or authority; (c) any ministry, department, bureau, division, authority,
agency, commission, or body entitled to exercise any administrative, executive, judicial, legislative, police, regulatory, or taxing authority or power; (d) any court, tribunal, or governmental arbitrator or arbitral body; (e) any
government-owned or -controlled institution or entity; (f) any enterprise or instrumentality performing a governmental function; and (g) any political party. 

1.66 “Government Official” is broadly interpreted and includes: (a) any elected or appointed Government official
(e.g., a legislator or a member of a ministry of health); (b) any employee or person acting for or on behalf of a Government, a Government department or agency, an institution or entity owned or controlled by a Government (e.g., a Healthcare
Professional employed by a Government-owned or -controlled hospital, or a person serving on a healthcare committee that advises a Government), or an enterprise or instrumentality performing a governmental function; (c) any candidate for public
office, or officer, employee, or person acting for or on behalf of a political party or candidate for public office; (d) an employee or person acting for or on behalf of a public international organization (e.g., the United Nations, the Red
Cross, or the World Bank); (e) any member of a military or a royal or ruling family; and (f) any person otherwise categorized as a Government official under Applicable Law. 

1.67 “HCP” or “Healthcare Professional” includes any physician, nurse, pharmacist, or other person
who may administer, prescribe, purchase, or recommend pharmaceutical products or other healthcare products. 
 1.68
“Healthcare Laws” means the federal Anti-kickback Statute (42 U.S.C. § 1320a-7b(b)), the Anti-Inducement Law (42 U.S.C. § 1320a-7a(a)(5)), the
Civil Monetary Penalty Statute (42 U.S.C. § 1320a-7a), the civil False Claims Act (31 U.S.C. §§ 3729 et seq.), the administrative False Claims Law (42 U.S.C. § 1320a-7b(a)), the Health Insurance Portability and Accountability Act of 1996 (42 U.S.C. § 1320d et seq.), the exclusion laws (42 U.S.C. § 1320a-7), the FD&C
Act, the Controlled Substances Act (21 U.S.C. §§ 801 et seq.), Section 1128G of the Social Security Act (the Physician Payment Sunshine Law), The Foreign Corrupt Practices Act (15 U.S.C. §
78dd-1, et seq.), the Medicare Program (Title XVIII of the Social Security Act), the Medicaid Program (Title XIX of the Social Security Act), the regulations promulgated pursuant to such laws, requirements of
the Medicaid Drug Rebate Program (42 U.S.C. § 1396r-8) and any state supplemental rebate program, requirements of Medicare average sales price reporting (42 U.S.C. §
1395w-3a), the Public Health Service Act (42 U.S.C. § 256b), the VA Federal Supply Schedule (38 U.S.C. § 8126), state pharmaceutical assistance programs and regulations under such laws, and Good
Clinical Practices, Good Laboratory Practices (GLP) (21 C.F.R. Part 58), and Good Manufacturing Practices (GMP) (21 C.F.R. Parts 210-211 and 820). 

1.69 [***] 

  
 11 

 1.70 [***] 

1.71 “IND” means: (a) an investigational new drug application filed with the FDA for authorization for the
investigation of a Compound or a Product pursuant to 21 C.F.R. Part 312, and (b) any of its foreign equivalents as filed with the applicable Regulatory Authorities in other countries or regulatory jurisdictions in the Territory, as applicable.

 1.72 “Indemnified Party” is defined in Section 13.3. 

1.73 “Indemnifying Party” is defined in Section 13.3. 

1.74 “Intellectual Property Rights” means all trade secrets, copyrights, Patent Rights, Trademarks, moral rights, Know-How and any and all other intellectual property or proprietary rights now known or hereafter recognized in any jurisdiction. 

1.75 “Intended Tax Treatment” is defined in Section 7.10.5. 

1.76 [***] 
 1.77
“Inventory Payment” is defined in Section 7.1. 
 1.78 [***] 

1.79 [***] 
 1.80
“Know-How” means any proprietary invention, discovery, development, data, information, process, method, technique or other know-how, whether or not
patentable. 
 1.81 “Knowledge” means actual knowledge of the individuals listed on Schedule 1.81 and
is not meant to require or imply that any particular inquiry or investigation has been undertaken, including obtaining any type of search (independent of that performed by the actual Governmental Authority during the normal course of patent
prosecution, as applicable, in a jurisdiction) or opinion of counsel. 
 1.82 “Licensed
Know-How” means Know-How Controlled by Pfizer or any of the Existing Pfizer Affiliates [***]. 

1.83 “Licensed Patent Rights” means all Patent Rights [***]. 

1.84 “Licensed Technology” means, collectively, the Licensed Patent Rights and Licensed
Know-How. 
 1.85 “Licensee” is defined in the introduction to this
Agreement. 
 1.86 “Licensee Indemnitees” is defined in Section 13.2. 

1.87 “Licensee Marginal Royalty Rates” is defined in Section 7.3.1. 

  
 12 

 1.88 “Licensee Product Trademarks” is defined in
Section 9.3.1. 
 1.89 “Licensee Quarter” means each of the four (4) thirteen (13)
week periods commencing on April 1 of any Licensee Year, consistently applied. 
 1.90 “Licensee Royalties” is
defined in Section 7.3.1. 
 1.91 “Licensee Third Party License” is defined in
Section 7.4.2(a). 
 1.92 “Licensee Year” means the twelve-month fiscal periods observed
by Licensee commencing on April 1 and ending March 31, consistently applied. 
 1.93 “Losses” means,
subject to Section 14.1, losses, damages, liabilities, payments, fines, fees, penalties, charges, judgments, settlement payments and costs and expenses including interest penalties and reasonable attorneys’ fees and
expenses. 
 1.94 “Major European Market Country” means [***]. The “Major European Market
Countries” means [***]. 
 1.95 “Manufacture” or “Manufacturing” means to make, have made,
produce, manufacture, process, fill, finish, package, label, perform quality assurance testing, release, ship or store a compound or product or any component thereof. When used as a noun, “Manufacture” or
“Manufacturing” means any and all activities involved in Manufacturing a compound or product or any component thereof. 

1.96 “NDA” means, with respect to a pharmaceutical product, a New Drug Application submitted to the FDA in accordance
with the FD&C Act or any analogous application or submission with any Regulatory Authority outside of the United States for the purpose of obtaining Regulatory Approval to market and sell the product, including, an application with the EMA for
the purpose of obtaining Regulatory Approval to market and sell the product, using the EMA’s centralized procedure. 
 1.97
“Net Sales” means [***]. 
 1.98 “Notice of Dispute(s) for Executive Resolution” is defined in
Section 18.3.2. 
 1.99 “Occurrence” is defined in
Section 12.4.6. 
 1.100 “Ongoing Clinical Trial Costs” is defined in
Section 5.9.2. 
 1.101 “Ongoing Clinical Trials” mean those Clinical Trials of the
Products that are ongoing as of the Effective Date and set forth on Schedule 1.101. 
 1.102 [***] 

1.103 [***] 

  
 13 

 1.104 “Order” means any writ, judgment, order, decree, injunction,
decision, verdict, award or ruling or other binding obligation of, or settlement or other similar agreement with, any Governmental Authority. 

1.105 “Other Active Ingredient(s)” is defined in Section 1.97. 

1.106 “Other Product” means any Product other than a Brepo Product. 

1.107 “Party” and “Parties” is defined in the introduction to this Agreement. 

1.108 “Patent Rights” means any and all (a) issued patents, (b) pending patent applications, including all
provisional applications, divisions, continuations, substitutions, continuations-in-part and renewals, and all patents granted thereon, (c) patents-of-addition, re-examinations, reissues and extensions or restorations by existing or future extension or restoration mechanisms, including patent term
adjustments, pediatric exclusivity, Patent Term Extensions or the equivalent thereof, (d) inventor’s certificates, (e) other forms of government-issued rights substantially similar to any of the foregoing and (f) United States
and foreign counterparts of any of the foregoing. 
 1.109 “Patent Term Extension” is defined in
Section 9.2.3. 
 1.110 “Permitted Contractor” means a CMO, CRO, CSO, distributor or
wholesaler, in each case, that is providing services on behalf of Licensee on a fee-for-service basis in connection with the Development, Commercialization or
Manufacture of the Compounds or Products. 
 1.111 “Person” means an individual, corporation, partnership, limited
liability company, trust, business trust, association, joint stock company, joint venture, pool, syndicate, sole proprietorship, unincorporated organization, Governmental Authority or any other form of entity not specifically listed herein. 

1.112 “Pfizer” is defined in the introduction to this Agreement. 

1.113 “Pfizer Indemnitees” is defined in Section 13.1. 

1.114 “Pfizer Marginal Royalty Rate” is defined in Section 7.3.2. 

1.115 [***] 

1.116 “Pfizer Product Trademarks” is defined in Section 9.3.1. 

1.117 “Pfizer Quarter” means each of the four (4) thirteen (13) week periods commencing on December 1 of any
Pfizer Year, consistently applied. 
 1.118 “Pfizer Royalties” is defined in
Section 7.3.2. 
 1.119 “Pfizer Third Party License” is defined in
Section 7.4.2(b). 

  
 14 

 1.120 “Pfizer Year” means the twelve-month fiscal periods observed
by Pfizer commencing on December 1 with respect to any country in the ROW and Japan, consistently applied. 
 1.121
“Pharmacovigilance Agreement” is defined in Section 5.8. 
 1.122 [***] 

1.123 “Pricing and Reimbursement Approval” means [***]. 

1.124 “Priority Review Voucher” means a “Section 529” US priority review voucher issued by the United
States Department of Health and Human Services that entitles the holder of such voucher to Priority Review of a single human drug application submitted under Section 505(b)(1) of the Act or Section 351(a) of the United States Public Health
Service Act, as further defined in Section 529(a)(2) of the Act (21 U.S.C. § 360ff(a)(2)). 
 1.125
“Product” means each (a) Brepo Product, (b) TYK2 Product and (c) each other product, dosage, substance or formulation, for use in the Field, that is Covered by a Valid Claim under the Licensed Patent Rights, in each
case of clauses (a), (b) and (c), other than [***]. 
 1.126 “Purchase Agreement” means the Stock Purchase Agreement
entered into by Priovant Holdings, Inc., Roivant and Pfizer and dated as of the date hereof. 
 1.127 “Recipients”
is defined in Section 11.1. 
 1.128 “Reference Product” is defined in
Section 1.59. 
 1.129 “Regulatory Approval” means, with respect to a Product in any
country or jurisdiction, any approval, registration, license or authorization that is required by the applicable Regulatory Authority to market and sell such Product in such country or jurisdiction, including any Pricing and Reimbursement Approvals.

 1.130 “Regulatory Authority” means, with respect to a particular country or jurisdiction, any Governmental
Authority responsible for granting Regulatory Approvals for a Product in such country or jurisdiction in the Territory. 
 1.131
“Regulatory Exclusivity” means exclusive marketing rights conferred by any Regulatory Authority with respect to a Product that prevents the Regulatory Authority from accepting or approving an application pursuant to [***]. 

1.132 “Regulatory Filings” means, with respect to a Product, any submission to a Regulatory Authority of any
appropriate regulatory application, including any IND, NDA, exclusivity requests, any submission to a regulatory advisory board, any marketing authorization application, any documentation for customs authorities, and any supplement or amendment
thereto. 
 1.133 “Regulatory Transfer Activities” is defined in Section 2 of Schedule
4. 

  
 15 

 1.134 “Relevant Records” is defined in
Section 8.1. 
 1.135 [***] 

1.136 “Report” is defined in Section 5.5.1. 

1.137 “Reporting Category” is defined in Section 5.5.1. 

1.138 “Residuals” means information in non-tangible form that is retained in
the unaided memory of persons who have had access to the Compounds, Products or Licensed Technology prior to the Effective Date, including ideas, concepts, know-how or techniques contained therein, but not
including any ideas, concepts, know-how, or techniques to the extent Covered by a Valid Claim in any Licensed Patent Right. A person’s memory will be considered to be unaided if the person has not
intentionally memorized the information for the purpose of retaining and subsequently using or disclosing it. 
 1.139
“Restricted Market” means, as applicable under Global Trade Control Laws, the Crimean Peninsula, Cuba, Iran, North Korea, and Syria. 

1.140 “Restricted Party” means any individual or entity on any of the following “Restricted Party
Lists”: the list of sanctioned entities maintained by the United Nations; the Specially Designated Nationals List and the Sectoral Sanctions Identifications List, as administered by the U.S. Department of the Treasury Office of Foreign
Assets Control; the U.S. Denied Persons List, the U.S. Entity List, and the U.S. Unverified List, all administered by the U.S. Department of Commerce; the entities subject to restrictive measures and the Consolidated List of Persons, Groups and
Entities Subject to E.U. Financial Sanctions, as implemented by the E.U. Common Foreign & Security Policy; the List of Excluded Individuals / Entities, as published by the U.S. Health and Human Services – Office of Inspector General;
any lists of prohibited or debarred parties established under the FD&C Act; the list of persons and entities suspended or debarred from contracting with the U.S. government; and similar lists of restricted parties maintained by the Governmental
Authorities of the countries that have jurisdiction over the activities conducted under this Agreement. 
 1.141 “Review
Period” is defined in Section 16.3. 
 1.142 [***] 

1.143 “Roivant” is defined in the introduction to this Agreement. 

1.144 “ROW” means the Territory, excluding the United States and Japan. 

1.145 “ROW Sales Milestone” is defined in Section 7.2.2. 

1.146 “ROW Sales Milestone Payment” is defined in Section 7.2.2. 

1.147 “Royalty Term” means, with respect to each Product in each country in the Territory or ROW, as applicable, the
period commencing on the First Commercial Sale of such Product in such country and expiring upon the later of: (a) [***] years following the date of First Commercial Sale of such Product in such country, (b) the expiration of all Regulatory
Exclusivity provided by an applicable Governmental Authority for such Product in such country and (c) the date upon which the use, sale, offer for sale or importation of such Product in such country would no longer infringe, but for the license
granted herein, a Valid Claim of a Licensed Patent Right. Notwithstanding anything herein to the contrary, the term “Royalty Term” will not apply to any Valid Claim that constitutes a [***]. 

  
 16 

 1.148 “SDNY” is defined in Section 18.3.8.

 1.149 “SEC” is defined in Section 12.2.17. 

1.150 [***] 

1.151 [***] 

1.152 “Significant Violation” means conduct that a reasonable person would consider a probable violation of applicable
policies or procedures designed to ensure compliance with Applicable Laws, which may result in significant or substantial liability if a Governmental Authority determined such conduct to be a violation of Applicable Law. 

1.153 [***] 

1.154 [***] 

1.155 [***] 

1.156 [***] 

1.157 [***] 

1.158 [***] 

1.159 “Specified Compound” means [***]. 

1.160 “Subsidiary” means, with respect to any Person, any other Person with respect to which such first Person
(a) possesses, directly or indirectly, the power to direct or cause the direction of the management and policies of such Person, whether through the beneficial ownership of voting securities, by contract or otherwise or (b) beneficially
owns at least fifty percent (50%) of the aggregate ordinary voting power of such Person. 
 1.161 “Tax Action” is
defined in Section 7.10.2. 
 1.162 “Tax Credit” is defined in
Section 7.10.3. 
 1.163 “Tax Payment” is defined in
Section 7.10.3. 
 1.164 “Term” is defined in Section 15.1. 

  
 17 

 1.165 “Terminated Products” means all [***], as applicable, with
respect to which this Agreement is terminated by either Party pursuant to Section 15.2. 
 1.166
“Terminated Territory” means each country with respect to which this Agreement is terminated by either Party pursuant to Section 15.2. 

1.167 “Territory” means worldwide, other than any Terminated Territory. 

1.168 “Third Party” means any Person other than a Party or an Affiliate of a Party. 

1.169 “Third Party Infringement” is defined in Section 10.1. 

1.170 [***] 

1.171 [***] 

1.172 [***] 

1.173 [***] 

1.174 [***] 

1.175 “Trademark” means trademarks, service marks, certification marks, trade dress, internet domain names, trade
names, identifying symbols, designs, product names, company names, slogans, logos or insignia, whether registered or unregistered, and all common law rights, applications and registrations therefor, and all goodwill associated therewith. 

1.176 “Transaction Agreements” means (a) this Agreement, [***] and (e) each other agreement or certificate
to be delivered by any Party hereto at the Closing contemplated hereby. 
 1.177 “Transfer Tax” is defined in
Section 7.10.1(b). 
 1.178 [***] 

1.179 [***] 

1.180 “TYK2” is defined in Section 1.181. 

1.181 “TYK2 Compounds” means [***] (“TYK2”), [***]. 

1.182 “TYK2 Product” means [***]. 

1.183 “U.S. Sales Milestone” is defined in Section 7.2.1. 

1.184 “U.S. Sales Milestone Payment” is defined in Section 7.2.1. 

1.185 “United States” or “U.S.” means the United States of America and its territories and
possessions. 

  
 18 

 1.186 “Valid Claim” means with respect to a particular country, a
claim of a Patent Right within the Licensed Patent Rights that [***] (i) has not been held permanently revoked, unenforceable or invalid by a decision of a court or other Governmental Authority of competent jurisdiction, which decision is unappealed
or unappealable within the time allowed for appeal and (ii) has not expired or been cancelled, withdrawn, abandoned, disclaimed or admitted to be invalid or unenforceable through reissue, disclaimer or otherwise and [***]. 

1.187 “VAT” is defined in Section 7.10.1(c). 

1.188 “Working Group” is defined in Section 6.4.6. 

1.189 Interpretation. Except where the context expressly requires otherwise, (a) the use of any gender herein shall be
deemed to encompass references to all genders, and the use of the singular shall be deemed to include the plural (and vice versa), (b) the words “include”, “includes” and “including” shall be deemed to be followed
by the phrase “without limitation”, (c) the word “will” shall be construed to have the same meaning and effect as the word “shall”, (d) any definition of or reference to any agreement, instrument or other
document herein shall be construed as referring to such agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth
herein), (e) any reference herein to any Person shall be construed to include the Person’s successors and assigns, (f) the words “herein”, “hereof” and “hereunder”, and words of similar import, shall be
construed to refer to this Agreement in its entirety and not to any particular provision hereof, (g) all references herein to Sections, Exhibits or Schedules shall be construed to refer to Sections, Exhibits or Schedules of this Agreement, and
references to this Agreement include all Exhibits and Schedules hereto, (h) the word “notice” means notice in writing (whether or not specifically stated) and shall include notices, consents, approvals and other written communications
contemplated under this Agreement, (i) provisions that require that a Party, the Parties or any committee hereunder “agree,” “consent” or “approve” or the like shall require that such agreement, consent or approval
be specific and in writing, whether by written agreement, letter, approved minutes or otherwise (but excluding instant messaging), (j) references to any specific law, rule or regulation, or article, section or other division thereof, shall be deemed
to include the then-current amendments thereto or any replacement or successor law, rule or regulation thereof, and (k) the term “or” shall be interpreted in the inclusive sense commonly associated with the term “and/or.”

  

	2.	 LICENSE GRANT. 

 

	 	2.1	 License Grant to Licensee. 

 

	 	2.1.1	 Licensed Patent Rights. Subject to the terms and conditions of this Agreement, including
Pfizer’s retained rights set forth in Section 2.4, Pfizer hereby grants to Licensee an exclusive (even as to Pfizer and its Affiliates, except as otherwise provided in Section 2.4),
sublicensable, through multiple tiers (subject to Section 2.2), milestone- and royalty-bearing right and license under the Licensed Patent Rights to use, have used, Develop, have Developed, Manufacture, have Manufactured,
Commercialize, and have Commercialized Compounds and Products in the Field within the Territory. The [***] shall be deemed to be included in the Licensed Patent Rights for the purpose of this Section 2.1.1 only, but only on
a fully paid-up, non-royalty bearing basis. 

  
 19 

	 	2.1.2	 Licensed Know-How. Subject to the terms and conditions of
this Agreement, Pfizer hereby grants to Licensee a non-exclusive, sublicensable, through multiple tiers (subject to Section 2.2), milestone- and royalty-bearing right and license to
use the Licensed Know-How to use, have used, Develop, have Developed, Manufacture, have Manufactured, Commercialize, and have Commercialized and otherwise Exploit Compounds and Products in the Field within the
Territory. 

  

	 	2.1.3	 Affiliates. To the extent any of the Licensed Technology is Controlled by an Existing Pfizer Affiliate,
then promptly following the Effective Date, Pfizer shall cause such Existing Pfizer Affiliate to take all necessary actions to give effect to the licenses granted under this Section 2.1, and carry out the other obligations
of Pfizer hereunder (including under Section 9.2 and Section 10.2). 

  

	 	2.1.4	 Wrong Pockets. [***] 

 

	 	2.2	 Sublicense Rights. [***] Licensee may sublicense the rights granted to it by Pfizer under Sections
2.1.1 and 2.1.2, through multiple tiers, without Pfizer’s approval. Any and all sublicenses shall be subject to the following requirements: 

  

	 	2.2.1	 All sublicenses shall be subject to and consistent with the terms and conditions of this Agreement and
shall (a) [***] and (b) preclude the granting of further sublicenses in contravention with the terms and conditions of this Agreement. 

  

	 	2.2.2	 In no event shall any sublicense relieve Licensee of any of its obligations under this Agreement.

  

	 	2.2.3	 Except with respect to a non-exclusive sublicense by Licensee to
an Affiliate or Permitted Contractor of less than all or substantially all of the rights granted to Licensee by Pfizer under Sections 2.1.1 and 2.1.2 and which does not specifically reference this Agreement or the Licensed Technology,
Licensee shall [***]. 

 In addition, Sections 2.2.1, 2.2.2, and 2.2.3 shall apply to
sublicenses granted by Pfizer under the rights granted by Licensee to Pfizer hereunder, mutatis mutandis. 
  

	 	2.3	 License Grant to Pfizer. Subject to the terms and conditions of this Agreement, Licensee hereby
grants to Pfizer (a) an exclusive (even as to Licensee and its Affiliates), sublicensable, through multiple tiers, milestone- and royalty-bearing right and license under the Licensed Patent Rights to Commercialize and have Commercialized
(i) Compounds and Products in the Field in the ROW and (ii) TYK2 Compounds and Other Products in the Field in Japan, and (b) a non-exclusive, sublicensable, through multiple tiers,
milestone- and royalty-bearing right and license under the Developed IP to Commercialize and have Commercialized (i) Compounds and Products in the Field in the ROW and (ii) TYK2 Compounds and Other Products in the Field in Japan. Licensee
shall use reasonable best efforts to promptly disclose to Pfizer all Developed IP during the Term. 

  
 20 

	 	2.4	 Retained Rights. [***] 

 

	 	2.5	 Residuals. Pfizer may use for any purpose the Residuals resulting from access to or work with the
Compounds, Products or Licensed Technology; provided that, for the avoidance of doubt, this Section 2.5 shall not constitute a grant back of the license and rights granted to Licensee under the Licensed Patent Rights
pursuant to Section 2.1.1 or a license or other rights under any Patent Right Controlled by Licensee. Any use made by the Pfizer of any such Residuals is on an “as is, where is” basis, with all faults and all
representations and warranties disclaimed and at Pfizer’s sole risk. 

  

	 	2.6	 No Additional Rights. Nothing in this Agreement shall be construed to confer any rights upon
Licensee by implication, estoppel, or otherwise as to any technology or Intellectual Property Rights of Pfizer or its Affiliates other than the rights in Licensed Technology expressly granted herein, regardless of whether such technology or
Intellectual Property Rights shall be dominant or subordinate to any Licensed Technology. 

  

	3.	 CLOSING. 

  

	 	3.1	 Closing. The closing of the transactions contemplated by this Agreement (the
“Closing”) shall take place remotely via the exchange of documents and signature pages on the date hereof. 

  

	 	3.2	 Closing Deliverables. 

 

	 	3.2.1	 Closing Deliverables and Actions by Pfizer. At the Closing, Pfizer shall deliver, or cause to be
delivered, to Licensee each of the Transaction Agreements duly executed by Pfizer or the applicable Pfizer Affiliate that is a party thereto. 

  

	 	3.2.2	 Closing Deliverables and Actions by Licensee. At the Closing, Licensee shall deliver, or cause to
be delivered, to Pfizer the following: 

  

	 	(a)	 a duly executed certificate by the Secretary of Licensee certifying as to: (i) the full force and effect
of the articles of incorporation and bylaws (or equivalent governing documents) of Licensee attached to such certificate as an exhibit, (ii) the accuracy and full force and effect of resolutions adopted by the board of directors of Licensee
approving the transactions contemplated by the Transaction Agreements, attached to such certificate as an exhibit, and (iii) the good standing of the Licensee in its jurisdiction of formation, with a certificate of good standing from such
jurisdiction dated no more than [***] prior to the Effective Date, attached to such certificate as an exhibit; 

  
 21 

	 	(b)	 each of the Transaction Agreements duly executed by Licensee or the applicable Licensee Affiliate that is a
party thereto; and 

  

	 	(c)	 the Inventory Payment pursuant to Section 7.1. 

 

	4.	 TRANSFER ACTIVITIES. Schedule 4 sets forth the documentation, materials and Licensed Know-How that Pfizer will transfer to Licensee or its designee and related activities and services to be performed by the Parties. If there is an inconsistency between Schedule 4 and this Agreement, the terms
of this Agreement shall prevail. 

  

	5.	 DEVELOPMENT; REGULATORY; MANUFACTURING. 

 

	 	5.1	 General. Except as set forth on Schedule 4 or as otherwise expressly set forth in this
Section 5, as between the Parties, Licensee shall have sole responsibility for [***] and the sole authority over and control of, the Development, Manufacture and Regulatory Approval of Compounds and Products in the Field in
the Territory. 

  

	 	5.2	 Alliance Management. 

 

	 	5.2.1	 Alliance Managers. Within [***] following the Effective Date, each Party will designate
(by written notice to the other Party) a single individual to act as its alliance manager under this Agreement to conduct the activities described below in Section 5.2.2 (each, an “Alliance Manager”). Each
Party may change the person designated as its Alliance Manager upon written notice (including via email notification) to the other Party. 

  

	 	5.2.2	 Roles and Responsibilities. The Alliance Managers will serve as the primary contact point
between the Parties for the activities under this Agreement for the purpose of providing each Party with information on the progress of Development and Commercialization of the Products and shall have the following responsibilities:

  

	 	(a)	 [***]; 

  

	 	(b)	 perform such other functions as agreed by the Parties. 

 

	 	5.3	 Diligence. Licensee shall itself, or through its Affiliates or sublicensees, use
Commercially Reasonable Efforts to [***] (collectively, the “Development Commitments”). 

  
 22 

	 	5.4	 Regulatory Filings. 

 

	 	5.4.1	 General. In connection with its efforts to Develop the Products, as between the Parties, Licensee
shall bear all responsibility [***] for submitting Regulatory Filings and obtaining and, subject to Section 5.4.6, maintaining Regulatory Approval for the Products in the Territory, subject to such Regulatory Transfer
Activities to be performed by Pfizer as set forth in Section 2 of Schedule 4. 

  

	 	5.4.2	 U.S. Review Rights. Licensee will own all Regulatory Filings, Regulatory Approvals, and related
regulatory documents for the Products for the U.S. and Brepo Products in Japan. Licensee shall provide Pfizer with a reasonable opportunity to review and comment on all material Regulatory Filings relating to all Products submitted to the FDA, as
well as all Global Regulatory Filings, by or on behalf of Licensee during the Term. Licensee shall promptly provide Pfizer with access to key correspondence with the FDA relating to Products. For clarity, [***]. 

 

	 	5.4.3	 ROW Review Rights. Notwithstanding Section 5.4.1, and except with
respect to Global Regulatory Filings which are covered by Section 5.4.2, Licensee shall provide Pfizer with an opportunity to review and comment on all material Regulatory Filings (i) in the ROW and (ii) other
than with respect to Brepo Compounds or Brepo Products, in Japan, prior to submission to the applicable Regulatory Authority. Licensee shall provide access to interim drafts of such material Regulatory Filings to Pfizer, and Pfizer shall provide its
comments on the near final drafts of such material Regulatory Filings or of proposed material actions within [***], or such other longer period of time mutually agreed to by the Parties. In the event that a Regulatory Authority establishes a
response deadline for any such material Regulatory Filing or material action shorter than such [***] period, the Parties shall work cooperatively to ensure that Pfizer has a reasonable opportunity for review and comment within such deadlines.
Licensee shall, [***]. 

  

	 	5.4.4	 ROW Information Rights. Subject to the immediately following sentence, Licensee shall provide
Pfizer with (a) access to or copies of all material written or electronic correspondence (other than Regulatory Filings) relating to the Development or Commercialization of (i) Compounds or Products received by Licensee or its Affiliates
or sublicensees from, or forwarded by Licensee or its Affiliates or sublicensees to, the Regulatory Authorities in the ROW and (ii) TYK2 Compounds or Other Products received by Licensee or its Affiliates or sublicensees from, or forwarded by
Licensee or its Affiliates or sublicensees to, the Regulatory Authorities in Japan, and (b) copies of all meeting minutes and summaries of all meetings, conferences, and discussions held by Licensee or its Affiliates or sublicensees with the
Regulatory Authorities (i) in the ROW and (ii) solely with respect to 

  
 23 

	 	
TYK2 Compounds or Other Products, in Japan, including copies of all contact reports produced by Licensee or its Affiliates or sublicensees, in each case ((a) and (b)) within [***] following the
end of each Calendar Quarter (which Licensee may provide to Pfizer through upload to a mutually acceptable data room). If such written or electronic correspondence received from any such Regulatory Authority relates to the withdrawal, suspension, or
revocation of any Regulatory Approval for a Product, the prohibition or suspension of the supply of a Compound or Product, or the initiation of any investigation, review, or inquiry by such Regulatory Authority concerning the safety of a Compound or
Product, Licensee shall notify Pfizer and provide Pfizer with copies of such written or electronic correspondence as soon as practicable, but not later than [***] after receipt of such correspondence. 

 

	 	5.4.5	 ROW Meeting Rights. Licensee shall provide Pfizer with prior written notice of any scheduled
meeting, conference, or discussion (including any advisory committee meeting) with a Regulatory Authority (i) in the ROW relating to a Product and (ii) in Japan relating to a Other Product, within [***] after Licensee or its Affiliate or
sublicensee first receives notice of the scheduling of such meeting, conference, or discussion (or within such shorter period as may be necessary in order to give Pfizer a reasonable opportunity to attend such meeting, conference, or discussion).
[***] 

  

	 	5.4.6	 Transfer of Regulatory Approvals in the ROW and Japan. As soon as practicable and in any event
within [***] following receipt of Regulatory Approval for (a) a Product in a country in the ROW or (b) a Other Product in Japan, Licensee shall execute and provide to Pfizer all documents (in a form reasonably acceptable to Pfizer)
required to transfer such Regulatory Approval to Pfizer, provided that if the provision of any such documents is delayed by a Regulatory Authority for reasons outside of Licensee’s reasonable control, then such period will be extended
for the period of delay by such Regulatory Authority. Licensee shall provide Pfizer with the status of the progress of each such Regulatory Approval transfer [***]. Licensee shall also provide a copy of each certificate of registration of the
transfer of each such Regulatory Approval to Pfizer promptly after receiving such certificate from the respective Regulatory Authority. Licensee shall use Commercially Reasonable Efforts to keep the transition of Regulatory Approvals for Products in
the ROW and Other Products in Japan as short as possible. Pfizer shall use Commercially Reasonable Efforts to assist, or to cause its Affiliates to assist, Licensee and its Affiliates in the transfer of Regulatory Approvals for Products in the ROW
and Other Products in Japan to Pfizer, including by providing Licensee and its Affiliates with any information reasonably requested by Licensee and necessary for the transfer of such Regulatory Approvals or requested by any Regulatory Authority and,
in each case, reasonably available to Pfizer or its Affiliates. Following the transfer of a Regulatory Approval for a Product in a country in the ROW to Pfizer or a Other Product in Japan to Pfizer, Pfizer shall bear all responsibility and expense
for maintaining such Regulatory Approval. 

  
 24 

	 	5.4.7	 Priority Review Voucher. If Licensee elects to transfer to a Third Party or otherwise monetize a
Priority Review Voucher, all proceeds thereof shall be allocated to Licensee. 

  

	 	5.5	 Progress Reporting. 

 

	 	5.5.1	 Semi-Annual Reports. During the First Reporting Window, [***]. 

  

	 	5.5.2	 Annual Reports. For each Reporting Category, after the end of the applicable First Reporting
Window, Licensee’s reporting obligations will be limited as follows: [***]. 

  

	 	5.5.3	 Conclusion of Reports. Notwithstanding the foregoing, Licensee’s reporting obligations to
Pfizer under Section 5.5.1 or 5.5.2 with respect to any and all Products described therein shall end on [***]. 

  

	 	5.5.4	 Cooperation. Licensee shall promptly respond to Pfizer’s reasonable inquiries regarding the
Development activities related to the Compounds and Products, and regarding clinical recruitment progress, occurred adverse events, and the status of any applications for Regulatory Approvals related to the Compounds and Products in Development by
Licensee. 

  

	 	5.6	 Permitted Contractors. Licensee may subcontract with Permitted Contractors to handle
certain clinical Development or Manufacture activities in the Territory and Commercialization activities in the U.S. and Japan, in Licensee’s reasonable discretion, consistent with the then-current Development Plan. As between the Parties, all
costs of Permitted Contractors will be borne solely by Licensee. 

  

	 	5.7	 Development Plan. Licensee’s plan for conducting Development activities with respect
to the Compounds and Products is set forth in the development plan set forth in Schedule 5.7, as amended by Licensee pursuant to this Section 5.7 (the “Development Plan”). For clarity, the
Development Plan shall not cover the Ongoing Clinical Trials, and the Development Plan is provided for informational purposes only and is not intended to expand or diminish the scope of Licensee’s diligence obligations in
Section 5.3. [***] 

  

	 	5.8	 Safety Reporting. The safety units from each of the Parties shall agree upon a
pharmacovigilance agreement (the “Pharmacovigilance Agreement”) for exchanging adverse event and other safety information relating to Compounds and Products prior to both Parties’ initiation of any clinical or marketing
activity implicating pharmacovigilance obligations for the Compounds and Products in the Territory. Such Pharmacovigilance Agreement shall ensure that adverse event and other safety information is exchanged according to a schedule that will permit
each Party to comply with Applicable Laws, including any local regulatory requirements as a Regulatory Approval holder. 

  
 25 

	 	5.9	 Ongoing Clinical Trials. 

 

	 	5.9.1	 General. From and after the Effective Date, Pfizer shall remain as sponsor of, and have sole
decision making authority and responsibility for directing the activities and conduct of, the Ongoing Clinical Trials; provided, that [***]. 

  

	 	5.9.2	 Ongoing Clinical Trial Costs. Pfizer shall bear [***] of all costs (external and internal)
invoiced to or incurred by Pfizer after the Effective Date in connection with the performance of the Ongoing Clinical Trials (“Ongoing Clinical Trial Costs”), except [***]. 

 

	 	(a)	 Within [***] after the end of each Calendar Quarter, Pfizer shall deliver to Licensee an invoice setting forth
the Ongoing Clinical Trial Costs reimbursable by Licensee pursuant to this Section 5.9.2, together with reasonable supporting documentation. Licensee shall pay to Pfizer its allocation of such Ongoing Clinical Trial Costs
within [***] of Pfizer’s delivery of the applicable undisputed invoice. In addition, (a) within [***] days after the end of each month, Pfizer shall deliver to Licensee a good faith estimate of the amount for which it anticipates invoicing
Licensee for reimbursable Ongoing Clinical Trial Costs pursuant to this Section 5.9.2 in the preceding month [***], (b) between [***] of each year, Pfizer shall deliver to Licensee a quarterly forecast of the amount for
which Pfizer anticipates that it will invoice Licensee through the conclusion of the Ongoing Clinical Trials, together with reasonable supporting documentation for such amount, and (c) if, at any time, Pfizer forecasts an aggregate increase or
decrease of more than [***] for any Ongoing Clinical Trial during any remaining [***] period compared to last forecast provided, Pfizer shall promptly provide Licensee updated an quarterly forecast through until completion of the applicable Ongoing
Clinical Trial within [***] of determining such increase or decrease. 

  

	 	(b)	 [***] 

  

	 	5.10	 [***] 

  

	 	5.11	 [***] 

  

	 	5.12	 Compliance. Licensee shall, and shall cause its Affiliates, to comply with all Applicable
Laws with respect to the Development and Manufacture of the Products. 

  
 26 

	6.	 COMMERCIALIZATION. 

 

	 	6.1	 General. 

  

	 	6.1.1	 U.S. and Japan. Subject to [***], Licensee shall have sole responsibility for [***], and the sole
authority over and control of, the Commercialization of Compounds and Products in the Field in the U.S. and Brepo Compounds and Brepo Products in the Field in Japan. Licensee shall have the sole right to invoice and book sales, establish all terms
of sale (including pricing and discounts) and warehousing, and distribute the Products in the U.S. and the Brepo Products in Japan and to perform or cause to be performed all related services. Licensee shall handle all returns, recalls, or
withdrawals, order processing, invoicing, collection, distribution, and inventory management with respect to the Products in the U.S. and Brepo Products in Japan. 

 

	 	6.1.2	 ROW. As between the Parties, Pfizer shall have sole responsibility for [***], and the sole authority
over and control of, the Commercialization of Compounds and Products in the Field in the ROW and TYK2 Compounds and Other Products in the Field in Japan. Pfizer shall have the sole right to invoice and book sales, establish all terms of sale
(including pricing and discounts) and warehousing, and distribute the Products in the ROW and the Other Products in Japan and to perform or cause to be performed all related services. Pfizer shall handle all returns, recalls, or withdrawals, order
processing, invoicing, collection, distribution, and inventory management with respect to the Products in the ROW and the Other Products in Japan. 

  

	 	6.2	 Diligence. 

  

	 	6.2.1	 Licensee. Licensee shall itself, or through its Affiliates or sublicensees, use Commercially Reasonable
Efforts to Commercialize [***]. 

  

	 	6.2.2	 Pfizer. Pfizer shall itself, or through its Affiliates or sublicensees, use Commercially
Reasonable Efforts to Commercialize [***]. 

  

	 	6.3	 [***] 

  

	 	6.4	 [***] 

  

	 	6.5	 Territory Integrity. 

 

	 	6.5.1	 Subject to its rights pursuant to Section 6.3, Pfizer hereby covenants and
agrees that during the Term it shall not (and shall cause its Affiliates not to), either itself or through a Third Party, Commercialize any (i) Products for use in the Field in the United States or (ii) Brepo Products for use in the Field
in Japan. Without limiting the generality of the foregoing, Pfizer shall not (a) engage in any 

  
 27 

	 	
advertising activities relating to (i) Products for use in the Field directed primarily to customers located in the United States or (ii) Brepo Products for use in the Field directed
primarily to customers located in Japan or (b) actively or intentionally solicit orders from any prospective purchaser of a (i) Product for use in the Field located in the United States or (ii) Brepo Product for use in the Field
located in Japan. To the extent permitted by Applicable Law, if Pfizer receives any order from a prospective purchaser for a (i) Product in the Field located in the United States or (ii) Brepo Product in the Field located in Japan, Pfizer
shall promptly refer that order to Licensee and shall not accept any such order or deliver or tender (or cause to be delivered or tendered) the Product under such order. If Pfizer should reasonably know that its customer or distributor is actively
engaged itself or through a Third Party in the sale or distribution of any Product inside the United States in the Field, then Pfizer shall (i) within [***] of becoming aware of such activities, notify Licensee regarding such activities and
provide all information reasonably available to Pfizer that Licensee may reasonably request concerning such activities and (ii) use Commercially Reasonable Efforts (including cessation of sales to such customer) necessary to limit such sale or
distribution inside the United States in the Field, unless otherwise agreed in writing by the Parties. 

  

	 	6.5.2	 Licensee hereby covenants and agrees that during the Term it shall not (and shall cause its Affiliates
not to), either itself or through a Third Party, Commercialize any (i) Products for use in the Field in the ROW or (ii) Other Products for use in the Field in Japan. Without limiting the generality of the foregoing, with respect to
countries within the ROW and Japan, Licensee shall not (a) engage in any advertising activities relating to (i) Products for use in the Field directed primarily to customers located in such countries within the ROW or (ii) Other
Products for use in the Field directed primarily to customers located in Japan or (b) actively or intentionally solicit orders from any prospective purchaser of a (i) Product for use in the Field located in such countries within the ROW or
(ii) Other Product for use in the Field located in Japan. To the extent permitted by Applicable Laws, if Licensee receives any order from a prospective purchaser for a (i) Product in the Field located in a country inside of the ROW or
(ii) Other Product in the Field located in Japan, Licensee shall promptly refer that order to Pfizer and shall not accept any such order or deliver or tender (or cause to be delivered or tendered) the Product under such order. If Licensee
should reasonably know that its customer or distributor is actively engaged itself or through a Third Party in the sale or distribution of any (i) Product inside the ROW in the Field or (ii) Other Product inside Japan in the Field, then
Licensee shall (i) within [***] of becoming aware of such activities, notify Pfizer regarding such activities and provide all information reasonably available to Licensee that Pfizer may reasonably request concerning such activities and
(ii) use Commercially Reasonable Efforts (including cessation of sales to such customer) necessary to limit such sale or distribution inside the ROW in the Field, unless otherwise agreed in writing by the Parties. 

  
 28 

	 	6.6	 [***] 

  

	 	6.7	 Compliance. Each Party shall, and shall cause its Affiliates, to comply with all Applicable Laws,
Anti-Corruption Laws, and Healthcare Laws with respect to the Commercialization of the Products. 

  

	7.	 PAYMENT TERMS. 

 

	 	7.1	 Inventory Payment. In consideration of the inventory set forth on Schedule 7.1, Licensee
shall pay to Pfizer a one-time non-refundable and non-creditable payment of $10,000,000 (the “Inventory
Payment”) within [***] of the Effective Date. The inventory set forth on Schedule 7.1 shall be transferred to Licensee as soon as reasonably practicable, and in any event within [***] from the Effective Date, and the Parties shall
negotiate in good faith and execute a quality agreement with respect to such inventory prior to such transfer, and in any event within [***] from the Effective Date. 

 

	 	7.2	 Sales Milestone Payments. 

 

	 	7.2.1	 U.S. Licensee shall pay to Pfizer the following one-time non-creditable, non-refundable payment when the milestone indicated below is achieved (such event, the “U.S. Sales Milestone” and such payment, the
“U.S. Sales Milestone Payment”). 

  

			
	 U.S. SALES MILESTONE
	  	 U.S. SALES MILESTONE PAYMENT

	[***]	  	[***]

 [***] 

Licensee shall notify Pfizer, via email notification to the Alliance Manger, [***] and to a finance contact provided by Pfizer, of the
achievement of the U.S. Sales Milestone Payment within [***] after the end of the applicable Licensee Quarter in which the U.S. Sales Milestone is achieved, following which Pfizer shall provide a written acknowledgement (which may be via email
notification) of Licensee’s notice and changes to Pfizer’s bank account information, if any. Licensee shall pay to Pfizer the U.S. Sales Milestone Payment within [***] following receipt of Pfizer’s written acknowledgement. For the
avoidance of doubt: (i) the U.S. Sales Milestone Payment shall be payable only once upon first achievement of the U.S. Sales Milestone; and (ii) satisfaction of the U.S. Sales Milestone by a sublicensee or assignee of, or Third Party
retained by, Licensee or its Affiliates shall be deemed to have been satisfied by Licensee for purposes of this Section 7.2.1. 

  
 29 

	 	7.2.2	 ROW. Pfizer shall pay to Licensee the following one-time non-creditable, non-refundable payment when the milestone indicated below is achieved (such event, the “ROW Sales Milestone” and such payment, the
“ROW Sales Milestone Payment”). 

  

			
	 ROW SALES MILESTONE
	  	 ROW SALES MILESTONE PAYMENT

	[***]	  	[***]

 Pfizer shall pay to Licensee the ROW Sales Milestone Payment within [***] after the end of the applicable
Pfizer Quarter in which the ROW Sales Milestone is achieved. For the avoidance of doubt: (i) the ROW Sales Milestone Payment shall be payable only once upon first achievement of the ROW Sales Milestone; and (ii) satisfaction of the ROW Sales
Milestone by a sublicensee or assignee of, or Third Party retained by, Pfizer or its Affiliates shall be deemed to have been satisfied by Pfizer for purposes of this Section 7.2.2. 

 

	 	7.3	 Royalty Payments. 

 

	 	7.3.1	 Licensee. Licensee shall pay to Pfizer non-refundable, non-creditable royalties in the amount of the marginal royalty rates (set forth below) (“Licensee Marginal Royalty Rates”) on the aggregate Net Sales resulting from the sale of (i) Products, on
a Product-by-Product basis, in the U.S. and (ii) Brepo Products, on a Brepo Product-by-Brepo Product basis, in Japan, during
each Licensee Year (collectively, “Licensee Royalties”). 

  

			
	 U.S. AND JAPAN NET SALES
	  	 LICENSEE MARGINAL ROYALTY RATE

	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]

 [***] 

Each Licensee Marginal Royalty Rate set forth in the table above shall apply only to that portion of the Net Sales of each Product in the U.S.
and each Brepo Product in Japan during a given Licensee Year that falls within the indicated range. Within [***] following the expiration of each Licensee Quarter (or [***] if such Licensee Quarter is the last Licensee Quarter of a Licensee Year)
after the date of the First Commercial Sale in the U.S., Licensee will provide Pfizer, via email notification to the Alliance Manger, [***] and to a finance contact provided by Pfizer, a report that includes reasonably detailed information regarding
a total monthly sales 

  
 30 

 
calculation of Net Sales of Product in the U.S., Net Sales of Brepo Product in Japan and all Licensee Royalties payable to Pfizer for the applicable Licensee Quarter, following which Pfizer shall
provide a written acknowledgement (which may be via email notification) of Licensee’s report and changes to Pfizer’s bank account information, if any. Licensee shall pay to Pfizer the Licensee Royalties within [***] following receipt of
Pfizer’s written acknowledgement. Licensee Royalties will be payable on a (i) Product-by-Product basis during the Royalty Term for such Product until the
expiration of the Royalty Term for such Product in the U.S. and (ii) Brepo Product-by-Brepo Product basis during the Royalty Term for such Product until the expiration of the Royalty Term for such Brepo
Product in Japan. For purposes hereof, Net Sales during the Royalty Term for each Product in the U.S. and each Brepo Product in Japan include sales of such Products that occur after the expiration of the Royalty Term or termination of this Agreement
where the Manufacture, use or other Exploitation of such Products was Covered by a Valid Claim of a Licensed Patent Right during the Royalty Term. 
  

	 	7.3.2	 Pfizer. Pfizer shall pay to Licensee non-refundable, non-creditable royalties in the amount of the marginal royalty rates (set forth below) (“Pfizer Marginal Royalty Rates”) on the aggregate Net Sales resulting from the sale of (i) Products, on a
Product-by-Product basis, in the ROW and (ii) Other Products, on an Other
Product-by-Other Product basis, in Japan, during each Pfizer Year (collectively, “Pfizer Royalties”). 

 

			
	 ROW AND JAPAN NET SALES
	  	 PFIZER MARGINAL ROYALTY RATE

	[***]	  	[***]
	[***]	  	[***]
	[***]	  	[***]

 Each Pfizer Marginal Royalty Rate set forth in the table above shall apply only to that portion of the Net
Sales of each Product in the ROW and each Other Product in Japan during a given Pfizer Year that falls within the indicated range. Pfizer shall pay to Licensee the applicable Pfizer Royalties within [***] following the expiration of each Pfizer
Quarter after the date of the First Commercial Sale in the ROW or Japan, as applicable. All ROW Royalty payments shall be accompanied by a report that includes reasonably detailed information regarding a total monthly sales calculation of Net Sales
of Product in the ROW, Net Sales of Other Product in Japan, and all Pfizer Royalties payable to Licensee for the applicable Pfizer Quarter (including any foreign exchange rates employed). Pfizer Royalties will be payable on a (i) Product-by-Product and country-by-country basis during the Royalty Term for such
Product in each country until the expiration of the Royalty Term for such Product in such country in the ROW and (ii) Other Product-by-Other Product basis during
the Royalty Term for such Product in Japan until the expiration of the Royalty Term for such Product in Japan. For purposes hereof, Net Sales during the Royalty Term for each Product in the ROW and each Other Product in Japan include sales of such
Products that occur after the expiration of the Royalty Term or termination of this Agreement where the Manufacture, use or other Exploitation of such Products was Covered by a Valid Claim of a Licensed Patent Right during the Royalty Term. 

  
 31 

	 	7.4	 Royalty Deduction. 

 

	 	7.4.1	 Expiration of Valid Claims and Regulatory Exclusivity. If, on a country-by-country and Product-by-Product basis, the Royalty Term for such Product in such
country is only being calculated under [***], then the Licensee Marginal Royalty Rates or Pfizer Marginal Royalty Rates used to calculate the Licensee Royalties or Pfizer Royalties, as applicable, with respect to such Product in such country shall
by reduced by [***]. If, on a country-by-country and Product-by-Product basis, the
Royalty Term for such Product in such country is only being calculated under [***], then the Licensee Marginal Royalty Rates or Pfizer Marginal Royalty Rates used to calculate the Licensee Royalties or Pfizer Royalties, as applicable, with respect
to such Product in such country shall by reduced by [***]. 

  

	 	7.4.2	 Third Party Licenses. 

 

	 	(a)	 Licensee, its Affiliates and sublicensees shall have the first right to obtain a license under any Third Party
Patent Rights that is [***] for the Exploitation of any Compound in any Product in the Field in the Territory (each such license, a “Licensee Third Party License”). Licensee, or its applicable Affiliate or sublicensee, shall pay all
amounts due under any such Licensee Third Party License; provided, that Licensee shall be entitled to reduce the Licensee Royalties due to Pfizer upon Net Sales of a Product by up to [***]. 

 

	 	(b)	 If Licensee does not, with respect to its first right under Section 7.4.2(a), obtain
a license under any Third Party Patent Rights that is necessary or reasonably useful for the Commercialization of any Compound in any Product in the Field in the ROW or any TYK2 Compound in any Other Product in the Field in Japan (“Pfizer
Third Party License”), then Pfizer, its Affiliates and sublicensees shall have the right to obtain such Pfizer Third Party License. Pfizer, or its applicable Affiliate or sublicensee, shall pay all amounts due under Pfizer Third Party
Licenses; provided, that Pfizer shall be entitled to reduce the Pfizer Royalties due to Licensee upon Net Sales of a Product by up to [***]. 

  

	 	7.4.3	 Generic Competition. If, at any time during the Royalty Term, Generic Competition exists in a
given country with respect to a Reference Product, then the Pfizer Marginal Royalty Rates and Licensee Marginal Royalty Rates used to calculate royalties for such Reference Product in such country shall be reduced by [***] for so long as such
Generic Competition exists. 

  
 32 

	 	7.4.4	 Maximum Deductions. Notwithstanding anything in Sections 7.4.1, 7.4.2, or 7.4.3 to the contrary,
under no circumstances shall the reductions set forth in this Section 7.4 cause (a) the total Licensee Royalties payable to Pfizer in any Licensee Quarter or Pfizer Royalties payable to Licensee in any Pfizer Quarter to be reduced by more
than [***] of the amount that would otherwise be due without giving effect to this Section 7.4, or (b) the Licensee Marginal Royalty Rates or Pfizer Marginal Royalty Rates used to calculate Licensee Royalties in any Licensee Quarter or
Pfizer Royalties in any Pfizer Quarter to be reduced by more than [***] of the rates set forth in Section 7.3. Notwithstanding the foregoing, [***]. 

  

	 	7.5	 Blended Royalty. Licensee acknowledges that (a) the Licensed
Know-How and the documentation and materials transferred to Licensee pursuant to Schedule 4 is proprietary and valuable and that, without the Licensed Know-How
and such documentation and materials Licensee would not be able to Develop, obtain and maintain Regulatory Approvals for, Manufacture or Commercialize the Compounds and Products, (b) access to Licensed
Know-How and such documentation and materials has provided Licensee with a competitive advantage in the marketplace beyond the exclusivity afforded by the Licensed Patent Rights and any Regulatory Exclusivity
and (c) the U.S. Sales Milestone Payment and Licensee Royalties, respectively, are, in part, intended to compensate Pfizer for such exclusivity and such competitive advantage. The Parties agree that the Licensee Marginal Royalty Rates set forth
in Section 7.3.1 reflect an efficient and reasonable blended allocation of the value provided by Pfizer to Licensee. 

  

	 	7.6	 Other Payments. Licensee shall pay to Pfizer any other amounts due under this Agreement within
[***] following receipt of an undisputed invoice. 

  

	 	7.7	 Late Payments. Any undisputed amount required to be paid by a Party hereunder which is not paid
on the date due shall bear simple interest thereafter accrued on the sum due to until the date of payment, to the extent permitted by law, at [***] over the prime rate effective for the date such payment was due, as reported by the [***]. Such
interest shall be computed on the basis of a year of three hundred sixty (360) days for the actual number of days payment is delinquent. 

  

	 	7.8	 Currency. All amounts payable and calculations under this Agreement shall be in United States
dollars. Notwithstanding anything to the contrary in this Agreement, conversion of sales recorded in local currencies shall be translated into United States dollars in a manner consistent with Pfizer’s normal practices used to prepare its
audited financial statements for external reporting purposes, provided that such practices use a widely accepted source of published exchange rates. 

  
 33 

	 	7.9	 Method of Payment. All payments from one Party to the other Party shall be made by wire transfer
via immediately available funds in U.S. dollars to credit the bank account as designated by such Party in writing to the other Party at least [***] before payment is due. Any payment which falls due on a date which is not a Business Day may be made
on the next succeeding Business Day. 

  

	 	7.10	 Taxes. 

  

	 	7.10.1	 General. 

 

	 	(a)	 Notwithstanding anything to the contrary in Section 7.10, each Party shall solely
bear and pay all taxes imposed on such Party’s net income or gain (in each case, however denominated) arising directly or indirectly from the activities of the Parties under this Agreement. Each Party shall comply with Applicable Laws and
regulations regarding filing and reporting for income tax purposes. 

  

	 	(b)	 Subject to Section 7.10.1(a), each Party shall bear and pay [***] of any transfer,
stamp or similar taxes or obligations (“Transfer Tax”) imposed on amounts payable by the paying Party to the receiving Party in connection with this Agreement. Each Party shall cooperate with the other Party to file any tax returns
(as required to be filed under Applicable Law) with respect to such Transfer Taxes. 

  

	 	(c)	 It is understood and agreed between the Parties that any payments made under this Agreement are exclusive of
any value added or similar tax (“VAT”), which shall be added thereon as applicable. In the event any payments made by a Party pursuant to this Agreement become subject to withholding taxes under the laws or regulation of any
jurisdiction, such Party (and its representatives) shall [***]. To the extent that a Party is required to deduct and withhold taxes on any payments under this Agreement, such Party shall [***]. 

 

	 	7.10.2	 Tax Actions. Notwithstanding anything in this Agreement to the contrary, if as a result of any
assignment or sublicense by the paying Party of its rights or obligations under this Agreement, any change in the paying Party’s tax residency, any change in the entity that originates the payment, or any failure on the part of the paying Party
to comply with Applicable Laws (other than any failure resulting from reliance on any certification or other information provided by the receiving Party with respect to the amount of withholding tax required to be withheld or deducted) with respect
to withholding taxes (including filing or record retention requirements) (a “Tax Action”) leads to the imposition of withholding tax liability or VAT on the other Party that would not have been imposed in the absence of a Tax Action
or in an increase in such liability above the 

  
 34 

	 	
liability that would have been imposed in the absence of such Tax Action, then (i) the sum payable by the Party that caused the Tax Action (in respect of which such deduction or withholding
is required to be made) shall be increased to the extent necessary to ensure that the other Party receives a sum equal to the sum which it would have received had no Tax Action occurred and (ii) the sum payable by the Party that caused a Tax
Action (in respect of which such deduction or withholding is required to be made) shall be made to the other Party after deduction of the amount required to be so deducted or withheld, which deducted or withheld amount shall be remitted in
accordance with Applicable Law. For the avoidance of doubt, a Party shall only be liable for increased payments pursuant to this Section 7.10.2 to the extent such Party engaged in a Tax Action that created or increased a
withholding tax or VAT on the other Party. 

  

	 	7.10.3	 Tax Credit. If a Party makes a payment in accordance with
Section 7.10.2 (a “Tax Payment”) and (a) a credit against, relief or remission for, or repayment of any Tax (“Tax Credit”) is attributable to that Tax Payment and (b) the
receiving Party determines in good faith that it has obtained and utilized that Tax Credit on an affiliated group basis, the receiving Party shall pay to the paying Party an amount equal to such Tax Credit, net of all
out-of-pocket expenses (including Taxes) of such receiving Party and without interest (other than interest paid by the relevant taxing authority with respect to such Tax
Credit). Notwithstanding anything else in this Section 7.10.3, in no event will the receiving Party be required to pay any amount to the paying Party pursuant to this Section 7.10.3, the payment of
which would place the receiving Party in a less favorable net after-tax position than the receiving Party would have been in if the tax giving rise to such Tax Credit had not been deducted, withheld or
otherwise imposed and the applicable Tax Payment had never been paid. This Section 7.10.3 shall not be construed to require the receiving Party to make available its tax returns (or any other information relating to its
taxes that it deems confidential) to the paying Party or any other Person. The receiving Party shall use its commercially reasonable efforts to obtain and utilize that Tax Credit on an affiliated group basis. 

 

	 	7.10.4	 Cooperation. The Parties agree to cooperate and produce on a timely basis any tax forms or
reports, including an IRS Form W-9 or an IRS Form W-8BEN-E, reasonably requested by the other Party in connection with any
payment made under this Agreement. 

  

	 	7.10.5	 [***] 

  
 35 

	8.	 RECORDS; AUDIT RIGHTS. 

 

	 	8.1	 Relevant Records. Each Party shall, and shall cause its Affiliates to, maintain complete and
accurate patent prosecution and maintenance records and financial books and records pertaining to sale of the Products by such Party, its Affiliates or sublicensees, including any and all calculations of the applicable amounts payable hereunder
(collectively, “Relevant Records”). Each Party shall maintain the Relevant Records for the longer of: (a) the period of time required by Applicable Law, or (b) [***] from the creation of such records. 

 

	 	8.2	 Audit Request. Each Party shall have the right during the Term and for [***] thereafter to
engage, [***], an independent public accounting firm of nationally recognized standing reasonably acceptable to the other Party and subject to confidentiality restrictions no less stringent than those set forth in
Section 11, to examine the Relevant Records from time-to-time as may be necessary to verify compliance with the terms of this Agreement. Such
examinations may not (a) be conducted for any Pfizer Quarter or Licensee Quarter, as applicable, more than [***] after the end of such Pfizer Quarter or Licensee Quarter, as applicable, (b) be conducted more than once in any [***] period
or (c) be repeated for the records for any Pfizer Quarter or Licensee Quarter, as applicable. Such audit shall be requested in writing at least [***] in advance and shall be conducted during the audited Party’s normal business hours and
otherwise in a manner that minimizes any interference to the audited Party’s business operations. The accounting firm shall disclose only whether the reports are correct or not, and the specific details concerning any discrepancies. No other
information shall be shared. 

  

	 	8.3	 Audit Fees and Expenses. The auditing Party shall bear [***] it may incur in connection with any
such audit of the Relevant Records; provided, however, in the event an audit reveals an underpayment by the other Party of more than [***] as to the period subject to the audit, the other Party shall reimburse the auditing Party for
any reasonable and documented out-of-pocket costs and expenses of the audit within [***] after receiving invoices thereof, and notwithstanding the provisions of
Section 8.2, the auditing Party shall have the right to have the accounting firm examine the Relevant Records of the other Party up to [***] every [***] for the [***] period following the audit revealing such underpayment.

  

	 	8.4	 Payment of Deficiency. If any audit establishes that (a) additional amounts were owed by the
audited Party, the audited Party shall pay the additional amounts, with interest from the date originally due as provided in Section 7.7 or (b) excess payments were made by the audited Party, the auditing Party shall
reimburse such excess payments, in either case ((i) or (ii)), within [***] after the date on which such audit is completed by the auditing Party. 

  

	9.	 INTELLECTUAL PROPERTY RIGHTS. 

 

	 	9.1	 Pre-existing IP. Subject only to the rights expressly
granted to Licensee under this Agreement, each Party shall retain all rights, title and interests in and to any Intellectual Property Rights that are owned, licensed or sublicensed by such Party prior to or independent of this Agreement.

  
 36 

	 	9.2	 Patent Prosecution. 

 

	 	9.2.1	 Patent Prosecution and Maintenance. Subject to Pfizer’s rights set forth in Sections
9.2.4 and 9.2.5 below, Licensee will be responsible for filing, prosecuting (including in connection with any reexaminations, revocation proceedings, inter partes reviews, oppositions and the like) and maintaining the
Licensed Patent Rights in the Territory and in Pfizer’s name [***] using, as of the Effective Date, Licensee to identify (a) lead patent counsel acceptable to Pfizer as its lead patent counsel in the U.S., Europe and Japan, respectively,
and (b) an annuity service acceptable to Pfizer as its annuity service provider to prepare, file, prosecute and maintain the Licensed Patent Rights. Licensee will select additional qualified patent counsel and foreign agents as necessary, in
each case reasonably acceptable to Pfizer, within [***] after the Effective Date. During the Term, Licensee will provide notice of any substitution of such counsel, foreign agents or annuity service providers within [***] after such substitution.
Before each submission is filed, Licensee will provide Pfizer a reasonable opportunity to review and comment on proposed, substantive submissions to any patent office and reasonably consider any comments provided by Pfizer to Licensee. Licensee will
keep Pfizer reasonably informed of the status of the Licensed Patent Rights by timely providing Pfizer copies of significant communications relating to such Licensed Patent Rights that are received from any patent office or patent counsel of record
or foreign associate. Licensee will provide Pfizer with a written update of the Licensed Patent Rights listed on Schedule 1.83 [***] or upon reasonable written request by Pfizer. 

 

	 	9.2.2	 Cooperation. The Parties agree to cooperate fully in the preparation, filing, prosecution, and
maintenance of the Licensed Patent Rights in the Territory under this Agreement. Cooperation shall include (a) executing all papers and instruments or requiring its employees or contractors to execute such papers to effectuate the ownership and
rights, including Patent Right extensions, supplementary protection certificates and the like, under this Agreement; (b) assisting in any license registration processes applicable to a particular Governmental Authority; and (c) promptly
informing the other Party of any matters coming to such Party’s attention that may materially affect the preparation, filing, prosecution, or maintenance of any such Licensed Patent Rights in the Territory. [***]. 

 

	 	9.2.3	 Patent Term Extensions. Licensee shall provide Pfizer with notice of each marketing application
and approval within [***] of such application and approval. Licensee shall have the first right with respect to making decisions regarding patent term extensions, including supplementary protection certificates, patent term linkages and any other
extensions that are now or in the future become available, wherever applicable (each, a “Patent Term Extension”), for Licensed Patent Rights in any country or other jurisdiction in connection with the Products. Prior to selecting
any 

  
 37 

	 	
such Patent Rights for a Patent Term Extension, Licensee shall notify Pfizer of any such selection and, at Pfizer’s request, discuss in good faith any issues or comments Pfizer may have with
respect to the selection of such Patent Rights and Licensee shall take into consideration Pfizer’s reasonable comments. Licensee shall have the responsibility of applying for any Patent Term Extension with respect to such Patent Rights and the
Products in the Territory. Licensee shall consult with Pfizer and keep Pfizer fully informed of its efforts to obtain such Patent Term Extension. As reasonably requested by Licensee in writing, Pfizer shall cooperate, [***], in obtaining such Patent
Term Extension. Licensee agrees to execute and deliver such further authorizations and instruments in advance of submission to provide Pfizer with reasonable comment rights and Licensee agrees to take into consideration such further actions as may
be requested by Pfizer to implement the foregoing. If Licensee does not exercise its rights to file Patent Term Extensions on any Licensed Patent Right in the Territory, Pfizer shall have the right, on a country-by-country basis to file a Patent Term Extension for such Licensed Patent Rights [***]; provided, however, that Pfizer shall not have such right in a country if such filing by Pfizer
would preclude Licensee from filing a Patent Term Extension for another Patent Right of Licensee’s choosing in such country. [***] For clarity, Pfizer will not seek, and will cause its Affiliates to not seek, to apply a Patent Term Extension to
(a) [***] without the prior written consent of Licensee or (b) any foreign counterpart for any Pfizer drug product, [***], without the prior written consent of Licensee, which shall not be unreasonably withheld, conditioned or delayed.

  

	 	9.2.4	 Failure to Prosecute or Maintain. Unless otherwise agreed in writing by Pfizer, Licensee shall
file, prosecute (including in connection with any reexaminations, revocation proceedings, inter partes reviews, oppositions and the like) and maintain each of the Licensed Patent Rights for at least [***] after the Effective Date.
After the [***] of the Effective Date, in the event Licensee elects to forego filing, prosecution or maintenance of the Licensed Patent Rights, Licensee shall notify Pfizer of such election at least [***] prior to any filing or payment due date, or
any other due date that requires action (“Election Notice”). Upon receipt of an Election Notice, Pfizer shall be entitled, upon written notice to Licensee, at its sole discretion [***], to file or to continue the prosecution or
maintenance of such Patent Right in such country in Pfizer’s name using counsel of its own choice [***]. As of the date Licensee provides Pfizer such Election Notice, Pfizer shall have the right, at its discretion, to either (a) terminate
the applicable license to such specific Licensed Patent Right or (b) convert the license granted in Section 2.1.1 under such Patent Right to a non-exclusive and non-sublicensable
license. In each case, Licensee shall promptly take all necessary steps to allow Pfizer to take over prosecution and maintenance and will have no further rights in respect of the filing, maintenance or enforcement of such Patent Right.

  
 38 

	 	9.2.5	 Retained Patent Prosecution and Maintenance. Pfizer will be responsible for
prosecuting (including in connection with any reexaminations, revocation proceedings, inter partes reviews, oppositions and the like) and maintaining only the [***] and any continuations and divisionals therefrom [***]. Before each
submission is filed, Pfizer will provide Licensee a reasonable opportunity to review and comment on proposed, substantive submissions to the United States Patent Office and reasonably consider any comments provided by Licensee to Pfizer. Pfizer will
keep Licensee reasonably informed of the status of the [***]. 

  

	 	9.3	 Trademarks. 

  

	 	9.3.1	 Determination and Ownership of Product Trademarks. Licensee shall determine, in consultation with
Pfizer, and exclusively own all right, title and interest in and to the Trademarks for Products Commercialized in the United States and Brepo Products Commercialized in Japan (the “Licensee Product Trademarks”), provided that if a
Trademark cannot be registered or used under Applicable Law (for regulatory, trademark law or other legal reasons), such Trademark will not be used and an alternate Trademark will be selected by Licensee in consultation with Pfizer. Pfizer shall
determine and select, in its sole discretion, the Trademarks for Products Commercialized in the ROW and Other Products Commercialized in Japan (the “Pfizer Product Trademarks”), including that Pfizer may elect, in its sole
discretion, to use a Trademark which is identical to a Licensee Product Trademark as a Pfizer Product Trademark, and Pfizer shall exclusively own all right, title and interest in and to the Pfizer Product Trademarks. 

 

	 	9.3.2	 Registration, Prosecution, Maintenance, Enforcement and Defense of Product Trademarks. Licensee shall
have the right, using counsel of its own choice, to conduct clearance activities (including searches), register, prosecute, maintain and enforce the Licensee Product Trademarks [***]. Pfizer shall have the right, using counsel of its own choice, to
conduct clearance activities (including searches), register, prosecute, maintain and enforce the Pfizer Product Trademarks [***]. 

  

	 	9.3.3	 Corporate Names. Each Party and its Affiliates will retain all right, title and interest in and to its
and their respective house marks, corporate names and corporate logos. Each Party shall not, and shall cause its Affiliates and its or their respective Sublicensees not to (a) do any act in connection with this Agreement that endangers,
destroys or similarly affects, in any material respect, the value of the goodwill pertaining to the corporate names of the other Party or (b) attack, dispute or contest the validity of or ownership of the corporate names of the other Party
anywhere in the world or any registrations issued or issuing with respect thereto. Each Party shall, and shall cause its Affiliates and its and their respective Sublicensees to, conform (y) to the customary industry standards for the protection
of the corporate names of the other Party and (z) to maintain the quality standards of the other Party with respect to the goods sold and services provided in connection with the corporate names of such other Party. 

  
 39 

	10.	 INFRINGEMENT; MISAPPROPRIATION. 

 

	 	10.1	 Notification. Each Party will promptly notify the other Party in writing of any actual or
threatened infringement, misappropriation or other violation by a Third Party of any Licensed Technology in the Field and in the Territory of which it becomes aware, including (i) the filing of an Abbreviated New Drug Application under
Section 505(j) of the FD&C Act or an application under Section 505(b)(2) of the FD&C Act naming a Product as a reference listed drug and including a certification under Section 505(j)(2)(A)(vii)(IV) or 505(b)(2)(A)(IV),
respectively or (ii) declaratory judgment action against any Licensed Patent Right in the Territory in connection with any infringement described in clause (i) (any of (i) or (ii) constituting a (“Third Party
Infringement”)). 

  

	 	10.2	 Infringement Action. 

 

	 	10.2.1	 Right of First Enforcement. 

 

	 	(a)	 Subject to Pfizer’s rights set forth in Section 10.2.1(c) below, Licensee shall
have the first right (but not the obligation), [***], to control enforcement of the Licensed Technology against any Third Party Infringement within the scope of its exclusive license. Prior to commencing any such action, Licensee shall consult with
Pfizer and shall give due consideration to Pfizer’s timely and reasonable recommendations regarding the proposed action. In order to establish standing, Pfizer, upon the request of Licensee, agrees to timely commence or to join any such
litigation, [***], and to cooperate with Licensee in such litigation [***]. Licensee shall give Pfizer timely notice of any proposed settlement of any such action instituted by Licensee and shall not, without the prior written consent of Pfizer,
which in the case of (i), (iii) and (iv) below shall not be unreasonably withheld, conditioned or delayed, enter into any settlement that would: (i) adversely affect the validity, enforceability or scope of any of the Licensed Patent
Rights, (ii) give rise to liability of Pfizer or its Affiliates, (iii) admit non-infringement of any Licensed Patent Rights, or (iv) otherwise impair Pfizer’s rights in any Licensed
Technology or this Agreement. 

  

	 	(b)	 If Licensee does not, with respect to its first right of enforcement under
Section 10.2.1(a), obtain agreement from the alleged infringer to desist or fails or refuses to initiate an infringement action by the earlier of (i) [***] following Licensee’s receipt of notice of the alleged
infringement, or (ii) [***] before the expiration date for filing such actions, then Pfizer shall have the right, at its sole discretion, to control such enforcement of the Licensed Technology [***]. 

  
 40 

	 	(c)	 Pfizer shall have the right (but not the obligation), [***], to control enforcement only of a patent issuing
from the [***] or any continuation or divisional thereof [***] against any Third Party Infringement. Prior to commencing any such action, Pfizer shall consult with Licensee and shall give due consideration to Licensee’s timely and reasonable
recommendations regarding the proposed action. Pfizer shall give Licensee timely notice of any proposed settlement of any such action instituted by Pfizer and shall not, without the prior written consent of Licensee, which shall not be unreasonably
withheld, conditioned or delayed, enter into any settlement that would adversely affect the validity, enforceability or scope of the [***]. 

  

	 	10.2.2	 Recoveries. Any recoveries resulting from an action instituted by Licensee relating to a claim of Third
Party Infringement pursuant to Section 10.2.1(a) shall first be applied to reimburse each Party’s costs and expenses incurred in connection therewith. Any remaining recoveries shall be retained by (or if received by
Pfizer, paid to) Licensee; [***]. If Licensee fails to institute an action or proceeding and Pfizer exercises its right to prosecute such infringement pursuant to Section 10.2.1(b), any remaining recoveries shall be
retained by Pfizer. 

  

	11.	 CONFIDENTIALITY [***]. 

 

	 	11.1	 Obligations. The receiving Party will protect all Confidential Information against unauthorized
disclosure to Third Parties with the same degree of care as the receiving Party uses for its own similar information, but in no event less than a reasonable degree of care. The receiving Party may only use the Confidential Information for exercising
its rights and performing its obligations under this Agreement, and may only disclose the Confidential Information to [***] (collectively, “Recipients”) who have a need to know such information for exercising its rights and
performing its obligations under this Agreement, provided that the receiving Party shall hold such Recipients to written obligations of confidentiality with terms and conditions at least as restrictive as those set forth in this Agreement.
All obligations of confidentiality under this Agreement shall survive expiration or termination of this Agreement for a period of [***]. 

  
 41 

	 	11.2	 Exceptions. 

  

	 	11.2.1	 Disclosure Required by Law. The restrictions set forth in this
Section 11 shall not apply to any Confidential Information that the receiving Party is required to disclose under Applicable Laws, the rules of any recognized stock exchange or any Order, provided that the receiving
Party: (a) provides the disclosing Party with prompt notice of such disclosure requirement if legally permitted, (b) affords the disclosing Party an opportunity to oppose, limit or secure confidential treatment for such required disclosure
and (c) if the disclosing Party is unsuccessful in its efforts pursuant to subsection (b), discloses only that portion of the Confidential Information that the receiving Party is required to disclose under Applicable Laws or the rules of any
recognized stock exchange or such Order as advised by the receiving Party’s legal counsel; provided that before disclosing this Agreement or any of the terms hereof pursuant to this Section 11.2.1, the Parties
will consult with one another on the terms of this Agreement to be redacted in making any such disclosure, with the disclosing Party providing as much advanced notice as is feasible under the circumstances, and giving consideration to the comments
of the other Party. For the avoidance of doubt, Licensee shall be permitted to file this Agreement with the Securities and Exchange Commission in connection with an initial public offering of Licensee’s stock or as otherwise required by
Applicable Law; provided that Licensee shall, [***], seek such confidential treatment of confidential portions of this Agreement as may be reasonably requested by Pfizer. Notwithstanding the foregoing or anything else to the contrary in this
Agreement, each Party (and each employee, representative or other agent of any Party) may disclose to any and all persons, without limitation of any kind, the tax treatment and tax structure of, and tax strategies relating to, the transactions in
which such Party participates pursuant to this Agreement. For this purpose, “tax structure” is limited to any facts relevant to the United States federal income tax treatment of such transactions and does not include information relating
to the specific identity of the Parties. 

  

	 	11.2.2	 Disclosure to Assignee of Payments. 

 

	 	(a)	 In the event that Pfizer wishes to assign, pledge or otherwise transfer its rights to receive some or all of
the U.S. Sales Milestone Payment and Licensee Royalties payable hereunder, Pfizer may disclose to a Third Party Confidential Information of Licensee reasonably relevant to such U.S. Sales Milestone or Licensee Royalties (as applicable) in connection
with any such proposed assignment, provided that Pfizer shall hold such Third Parties to written obligations of confidentiality and non-use with terms and conditions at least as restrictive as those set
forth in this Agreement. 

  

	 	(b)	 In the event that Licensee wishes to assign, pledge or otherwise transfer its rights to receive some or all of
the ROW Sales Milestone Payment and Pfizer Royalties payable hereunder, Licensee may disclose to a Third Party Confidential Information of Pfizer reasonably relevant to such ROW Sales Milestone or Pfizer Royalties (as applicable) in connection with
any such proposed assignment, provided that Licensee shall hold such Third Parties to written obligations of confidentiality and non-use with terms and conditions at least as restrictive as those set
forth in this Agreement. 

  
 42 

	 	11.2.3	 Use of Residuals. The restrictions set forth in this Section 11 shall not
apply to the use of Residuals in accordance with Section 2.5. 

  

	 	11.3	 Ongoing Obligation for Confidentiality. Upon expiration or termination of this Agreement, the
receiving Party shall, and shall cause its Recipients to, destroy or return (as requested by the disclosing Party) any Confidential Information of the disclosing Party, except that the receiving Party (a) may retain a single copy of
Confidential Information for the sole purpose of (i) ascertaining its rights and responsibilities in respect of such information and (ii) exercising its rights that expressly survive the expiration or termination of this Agreement and
(b) shall not be required to destroy any computer files stored securely by the receiving Party that are created by automatic system back up. 

  

	 	11.4	 [***] 

  

	12.	 REPRESENTATIONS, WARRANTIES AND COVENANTS. 

 

	 	12.1	 Representations and Warranties by Each Party. Each Party represents and warrants to the other
Party as of the Effective Date that: 

  

	 	12.1.1	 it is a corporation duly organized, validly existing, and in good standing under the laws of its
jurisdiction of formation; 

  

	 	12.1.2	 it has full corporate power and authority to execute, deliver, and perform under the Transaction
Agreements to which it will be a party, and has taken all corporate action required by Applicable Law and its organizational documents to authorize the execution and delivery of the Transaction Agreements to which it will be a party and the
consummation of the transactions contemplated by the Transaction Agreements to which it will be a party; 

  

	 	12.1.3	 the Transaction Agreements to which it will be a party will, at and after the Closing, constitute a
valid and binding agreement enforceable against it in accordance with their terms; 

  

	 	12.1.4	 all consents, approvals and authorizations from all Governmental Authorities or other Third Parties
required to be obtained by such Party in connection with the Transaction Agreements to which it will be a party have been obtained; and 

  
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	 	12.1.5	 the execution and delivery of the Transaction Agreements to which it will be a party and all other
instruments and documents required to be executed pursuant to the Transaction Agreements to which it will be a party, and the consummation of the transactions contemplated thereby do not and shall not: (i) conflict with or result in a breach of
any provision of its organizational documents, (ii) result in a breach of any agreement to which it is a party that would impair the performance of its obligations thereunder; or (iii) violate any Applicable Law. 

 

	 	12.2	 Representations and Warranties and Covenants by Pfizer. Pfizer represents and warrants to
Licensee as of the Effective Date that: [***] 

  

	 	12.3	 Representations, Warranties and Covenants by Licensee. [***] 

 

	 	12.4	 Representations, Warranties and Covenants Related to Anti-Corruption Laws and Healthcare Laws. Without
limiting the generality of Section 12.3.2, Licensee represents, warrants and covenants to Pfizer as of the Effective Date as follows: 

 

	 	12.4.1	 Licensee shall comply with all applicable Anti-Corruption Laws and Healthcare Laws. [***]

  

	 	12.5	 Representations, Warranties and Covenants Related to Global Trade Control Laws. Without limiting the
generality of Section 12.3.2, Licensee represents, warrants and covenants to Pfizer as follows: [***] 

  

	 	12.6	 No Action Required Which Would Violate Law. In no event shall either Party be obligated under
this Agreement to take any action or omit to take any action that such Party believes, in good faith, would cause such Party to violate any Applicable Law, including the Anti-Corruption Laws and Global Trade Control Laws. 

 

	 	12.7	 No Other Warranties. EXCEPT AS EXPRESSLY STATED IN THIS SECTION 12, NEITHER PARTY MAKES
ANY REPRESENTATIONS OR EXTENDS ANY WARRANTIES OF ANY KIND, EITHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE, INCLUDING WARRANTIES OF TITLE, NON-INFRINGEMENT, VALIDITY, ENFORCEABILITY, MERCHANTABILITY AND
FITNESS FOR A PARTICULAR PURPOSE. EXCEPT AS EXPRESSLY STATED IN THIS SECTION 12, ANY INFORMATION OR MATERIALS PROVIDED BY PFIZER OR ITS AFFILIATES IS MADE AVAILABLE ON AN “AS IS” BASIS WITHOUT WARRANTY WITH
RESPECT TO COMPLETENESS, COMPLIANCE WITH REGULATORY STANDARDS OR REGULATIONS OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER KIND OF WARRANTY WHETHER EXPRESS OR IMPLIED. 

 

	 	12.8	 Disclaimer. Licensee hereby expressly acknowledges and agrees that Pfizer makes no representation
or warranty with respect to any estimates, projections, forecasts, plans or budgets that may have been provided to Licensee. Licensee (a) specifically disclaims that it is relying upon or has relied upon any representations or warranties other
than as set forth in Sections 12.1 and 12.2, that may have been made by any 

  
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Person, and acknowledges and agrees that Pfizer and its Affiliates specifically disclaimed and do hereby specifically disclaim any such other representation or warranty made by any Person,
(b) specifically disclaims any obligation or duty by Pfizer and its Affiliates to make any disclosures of fact not required to be disclosed pursuant to the specific representations and warranties set forth in Sections 12.1 and
12.2 and (c) is entering into the transactions contemplated hereby and acquiring the Licensed Technology in connection with the transactions contemplated hereby subject only to the specific representations and warranties of Pfizer set
forth in Sections 12.1 and 12.2. Licensee hereby further acknowledges that (i) it has conducted, to its satisfaction, an independent investigation, due diligence review and verification of the Licensed Technology and (ii) it
is an informed and sophisticated Person and has engaged advisors experienced in the evaluation and consummation of transactions of the type contemplated hereunder. 

 

	 	12.9	 Other Government Approvals. Each of Licensee and Pfizer shall cooperate with the other Party and
shall use reasonable efforts to make all registrations, filings and applications, to give all notices and to obtain as soon as practicable all governmental or other consents, transfers, approvals, orders, qualifications authorizations, permits and
waivers required in connection with this Agreement, if any, and to do all other things necessary or desirable for the consummation of the transactions as contemplated hereby. 

 

	13.	 INDEMNIFICATION. 

 

	 	13.1	 Indemnification by Licensee. From and after the Closing, Licensee agrees to indemnify, hold harmless and
defend Pfizer and its Affiliates, and its and their respective officers, directors, employees, contractors, agents and successors and assigns (collectively, “Pfizer Indemnitees”), from and against any Losses to the extent arising or
resulting from: (a) [***], (e) the negligence, recklessness or wrongful intentional acts or omissions of Licensee or its Affiliates, contractors, subcontractors or sublicensees in the exercise of their rights or performance of their obligations
hereunder, (f) breach by Licensee of any representation, warranty or covenant as set forth in this Agreement or (g) breach by Licensee of the scope of the license set forth in Section 2.1. Notwithstanding the
foregoing, Licensee shall not be liable and have no obligation to indemnify Pfizer to the extent such losses arise out of or result from (a) the breach by Pfizer of any representation, warranty or covenant set forth in this Agreement, or
(b) the negligence, recklessness, wrongful intentional act or omission, or violation of Applicable Law by any Pfizer Indemnitee. 

  

	 	13.2	 Indemnification by Pfizer. From and after the Closing, Pfizer agrees to indemnify, hold harmless
and defend Licensee and its Affiliates, and its and their respective officers, directors, employees, agents and successors and assigns (collectively, “Licensee Indemnitees”), from and against any Losses to the extent arising or
resulting from: (a) the negligence, recklessness or wrongful intentional acts or omissions of Pfizer or its Affiliates, contractors, subcontractors or sublicensees in the exercise of their rights or performance of their obligations hereunder
[***], or 

  
 45 

	 	
(e) breach by Pfizer of any representation, warranty or covenant as set forth in this Agreement. Pfizer shall not be liable and have no obligation to indemnify Licensee to the extent such
losses arise out of or result from (a) the breach by Licensee of any representation, warranty or covenant set forth in this Agreement, or (b) the negligence, recklessness, wrongful intentional act or omission, or violation of Applicable
Law by any Licensee Indemnitee. 

  

	 	13.3	 Indemnification Procedure for Third Party Claims. In connection with any claim of a Third Party
for which a Pfizer Indemnitee or Licensee Indemnitee (either of the foregoing, the “Indemnified Party”) seeks indemnification from the other Party (the “Indemnifying Party”) pursuant to this Agreement, the
Indemnified Party shall: (a) give the Indemnifying Party prompt written notice of the claim, the amount or the estimated amount of damages sought under such claim to the extent then ascertainable and, to the extent practicable, any other
material details pertaining thereto; provided, however, that failure to provide such notice or to include the foregoing information shall not relieve the Indemnifying Party from its liability or obligation hereunder, except to the
extent of any material prejudice as a direct result of such failure; (b) cooperate with the Indemnifying Party, [***], in connection with the defense and settlement of the claim; and (c) permit the Indemnifying Party to assume control of
the defense and settlement of the claim, [***]; provided, however, that the Indemnifying Party may not settle the claim without the Indemnified Party’s prior written consent, which shall not be unreasonably withheld, conditioned
or delayed, unless such settlement (x) provides for the payment by the Indemnifying Party of money as sole relief for the claimant (other than as contemplated by the Deductible), (y) results in the full and general release of the Indemnified
Party from all liabilities arising or resulting from such claim, and (z) involves no finding or admission of any violation of Applicable Law or the rights of any Person and does not have an effect on any other claims that may be made against
the Indemnified Party. If the Indemnifying Party does not assume control of the defense and settlement of such claim, then the Indemnified Party shall control the defense and settlement of such claim with counsel of its selection, [***]. Either the
Indemnified Party (if such claim is controlled by the Indemnifying Party) or the Indemnifying Party (if such claim is controlled by the Indemnified Party) shall have the right to participate (but not control) and be represented in any suit or action
by advisory counsel of its selection [***]. Notwithstanding the foregoing, if the Indemnifying Party assumes control of the defense and settlement of such claim, the Indemnified Party will have the right to employ separate counsel [***], in
connection with the defense and settlement of the claim if: (i) there are or may be legal defenses available to the Indemnified Party that are different from or additional to those available to the Indemnifying Party; or (ii) in the
reasonable opinion of counsel to the Indemnified Party, a conflict or potential conflict exists between the Indemnified Party and Indemnifying Party that would make such separate representation advisable. In the event that the Indemnified Party
controls the defense and settlement of such claim, the Indemnified Party may not settle such claim without the Indemnifying Party’s prior written consent, which shall not be unreasonably withheld, conditioned or delayed. 

  
 46 

	 	13.4	 Indemnification Procedure for Direct Claims. In connection with any claim for indemnification
that an Indemnified Party wishes to make pursuant to this Agreement that does not arise or result from a claim by a Third Party, the Indemnified Party shall give the Indemnifying Party prompt written notice of such claim, the section(s) of this
Agreement that form the basis of the claim for indemnification, the amount or the estimated amount of damages sought under such claim to the extent then ascertainable and, to the extent practicable, any other material details pertaining thereto;
provided, however, that failure to provide such notice or to include the foregoing information shall not relieve the Indemnifying Party from its liability or obligation hereunder, except to the extent of any material prejudice as a
direct result of such failure. Upon receipt of any such notice, the Indemnified Party and the Indemnifying Party shall use commercially reasonable efforts to cooperate and arrive at a mutually acceptable resolution of such claim within [***] of the
Indemnified Party’s receipt of such notice. If a mutually acceptable resolution cannot be reached between the Indemnified Party and the Indemnifying Party within such [***], the Indemnified Party shall be free to seek enforcement of its rights
to indemnification under this Agreement with respect to such claim. 

  

	14.	 LIMITATION OF LIABILITY. 

 

	 	14.1	 Damages Waiver. EXCEPT FOR [***], NEITHER PARTY SHALL BE LIABLE TO ANY PERSON HEREUNDER FOR ANY
SPECIAL, EXEMPLARY OR PUNITIVE DAMAGES, OR ANY DAMAGES THAT ARE SPECULATIVE OR NOT REASONABLY FORESEEABLE AS A PROXIMATE RESULT OF THE BREACH BY A PARTY OF ANY OF ITS REPRESENTATIONS, WARRANTIES, COVENANTS OR AGREEMENTS UNDER THIS AGREEMENT,
REGARDLESS OF WHETHER IT HAS BEEN INFORMED OF THE POSSIBILITY OR LIKELIHOOD OF SUCH DAMAGES OR THE TYPE OF CLAIM, CONTRACT OR TORT (INCLUDING NEGLIGENCE). 

  

	 	14.2	 [***] 

  

	 	14.3	 [***] 

  

	 	14.4	 Survival. The representations and warranties contained in this Agreement shall survive the
Closing until the [***] of the Effective Date, except that (a) the representations and warranties contained in Section 12.1 shall survive the Closing until [***] after expiration of the relevant statute of limitations
period, and (b) the representations and warranties contained in Section 12.2.4 shall survive the Closing until the [***] of the Effective Date and, in each case, all rights to indemnification hereunder for any breach
of or inaccuracy in any representation or warranty shall terminate and expire on, and no action or proceedings seeking damages or other relief for breach of any representation or warranty or for misrepresentation or inaccuracy shall be commenced
after, such date. All covenants and agreements of the Parties requiring performance in full prior to the Effective Date shall survive until the Effective Date and all other covenants and agreements contained herein shall survive until the expiration
of the relevant statute of limitations period, and, in each case, all rights to indemnification 

  
 47 

	 	
hereunder for any breach of any covenant or agreement shall terminate and expire on, and no action or proceedings seeking damages or other relief for breach of any covenant or agreement shall be
commenced after, such date. In the event that notice of any claim for indemnification under Section 13 has been given pursuant to Section 13.3 or Section 13.4, as the case
may be, within the applicable survival period, the representations, warranties, covenants or agreements that are the subject of such indemnification claim (and the right to pursue such claim) shall survive with respect to such claim until such time
as such claim is finally resolved. 

  

	 	14.5	 Exclusive Remedy. Except for any claim for Fraud, gross negligence or willful misconduct, the
provisions of Section 13 and this Section 14 shall be the exclusive monetary remedy of the Parties for any matter subject to indemnification pursuant to Section 13, except
(a) as set forth in Section 18.4 and (b) to the extent the procedures of Section 2.1.4 would fully mitigate Losses with respect to a breach of any representation or warranty in this
Agreement, the procedures of Section 2.1.4 will be the sole and exclusive remedy of the Licensee Indemnitees for any such breach. 

  

	 	14.6	 Insurance Recovery. Notwithstanding the foregoing, the indemnifiable Losses shall be net of
(a) the amount of any insurance proceeds actually received by the Indemnified Party (offset by any increase in premium resulting therefrom and after deducting therefrom the full amount of the out-of-pocket fees, costs and expenses incurred by it in procuring such recovery and any taxes payable or expected to be payable thereon), and each Indemnified Party agrees to file claims under each
applicable insurance policy and to use commercially reasonable efforts to pursue all such insurance claims (but, shall not include an obligation to commence litigation), (b) any indemnity or contribution amounts actually recovered by such
Indemnified Party from a Third Party in respect of such indemnifiable Losses (after deducting therefrom the full amount of the out-of-pocket fees, costs and expenses
incurred by it in procuring such recovery and any taxes payable or expected to be payable thereon), and (c) the amount of any actual reduction in net taxes as a result of such indemnifiable Losses, solely for the taxable year of the incurrence,
accrual or payment of such indemnifiable Losses (treating any such benefit as the last item of deduction for the applicable tax year). 

  

	 	14.7	 No Set-Off. Notwithstanding anything to the contrary,
neither Party shall set off any indemnifiable Losses against the U.S. Sales Milestone Payment, ROW Sales Milestone Payment, Licensee Royalties, or Pfizer Royalties, as applicable, that would otherwise be payable to the other Party pursuant to
Section 7. 

  

	15.	 TERM; TERMINATION. 

 

	 	15.1	 Term. The term of this Agreement (“Term”) shall commence as of the Effective
Date and shall expire, on a Product-by-Product and country-by-country basis, on the
expiration of the applicable Royalty Term, unless earlier terminated, as provided in this Section 15. Upon expiration of the Term for any Product, the licenses granted to Licensee under this Agreement shall become fully paid-up, royalty-free, transferable, perpetual and irrevocable, with the right to grant sublicenses, through multiple tiers, with respect to such Product in the Field in the Territory. 

  
 48 

	 	15.2	 Termination for Cause. Each Party shall have
the right, without prejudice to any other remedies available to it at law or in equity, to terminate this Agreement in its entirety in the event the other Party materially breaches any of its obligations hereunder and fails to cure such breach
within [***] of receiving notice thereof; provided, however, if such breach is capable of being cured, but cannot be cured within such [***] period, and breaching Party initiates actions to cure such breach within such period and
thereafter diligently pursues such actions, the breaching Party shall have such additional period as is reasonable to cure such breach, but in no event will such additional period exceed [***]; and provided, further, that in the event that
any such material breach by the breaching Party is limited to the [***] or one or more (but not all) countries, then the non-breaching Party shall have right to terminate solely with respect to all [***] or
such countries, as applicable. Any termination by a Party under this Section 15.2 shall be without prejudice to any damages or other legal or equitable remedies to which it may be entitled from the breaching Party.

  

	 	15.3	 Termination for Convenience. At any time, Licensee shall have the right to terminate [***].

  

	 	15.4	 Effects of Termination. 

 

	 	15.4.1	 Termination in its Entirety by Licensee for Cause. In the event that Licensee terminates this Agreement
in its entirety pursuant to Section 15.2, the following shall apply: 

  

	 	(a)	 Rights and Obligations. Except as otherwise provided herein, including pursuant to
Section 15.5, all rights and obligations of each Party hereunder shall cease, including, for clarity, all licenses granted to Pfizer hereunder. 

 

	 	(b)	 Licenses. All rights and licenses granted to Licensee hereunder shall become fully paid-up, irrevocable and perpetual. 

  

	 	(c)	 Transition. During the notice period provided in Section 15.2, at
Licensee’s sole option, Licensee shall prepare and the Parties shall negotiate a transition plan that will include, at a minimum, a plan for accomplishing the activities described in this Section 15.4.1(c).

  

	 	(i)	 Continued Exploitation. At Licensee’s request [***], Pfizer shall continue on-going Exploitation for a mutually agreed-upon period following the termination of this Agreement, which period shall not be [***] unless otherwise agreed to by the Parties. For avoidance of doubt, if Licensee
chooses not to continue a Clinical Trial initiated by Pfizer, [***] of winding down such Clinical Trial, including compliance with any ethical or other requirements imposed by an applicable Regulatory Authority. 

  
 49 

	 	(ii)	 Technology Transfer. At Licensee’s request, Pfizer shall make available to Licensee all currently
available records and data which exist and are Controlled by Pfizer as of the effective date of termination and are necessary or useful for Licensee to continue Commercializing and Exploiting Compounds and Products in the Field in the Territory.
 

  

	 	(iii)	 Regulatory Matters. At Licensee’s request, Pfizer shall transfer and assign to Licensee (or its
designee) all Regulatory Approvals and Regulatory Filings held by Pfizer with respect to Compounds and Products, provided that if such transfer and assignment is not permitted by the applicable Regulatory Authority, Pfizer shall permit
Licensee to cross-reference and rely upon such Regulatory Approvals and Regulatory Filings. Pfizer shall make available to Licensee copies of all regulatory documentation and records related to Compounds and Products, including information contained
in the regulatory and safety databases. The Parties shall cooperate to ensure the prompt transition of regulatory responsibilities for Compounds and Products from Pfizer to Licensee. 

 

	 	(iv)	 Trademarks. Licensee shall have, and Pfizer does hereby grant to Licensee, a fully paid-up, royalty-free, worldwide, transferable, sublicensable, perpetual and irrevocable license to use the Pfizer Product Trademarks, if any, solely for the purpose of using, Developing, Commercializing and
Manufacturing the Products in the ROW and Japan. Licensee shall have a transitional license to use Pfizer’s Trademarks and promotional materials solely for the purpose of using, Developing, Commercializing and Manufacturing the Products.

  

	 	(v)	 Inventory and Supply. At Licensee’s request, Pfizer shall transfer to Licensee (or its designee)
all Compound and Product, components and in-process inventory held by Pfizer with respect to the Manufacture of Compounds and Products as of such date of termination, if any. At Licensee’s request, if
Pfizer has licensed to a CMO to Manufacture the Compounds or Products, Pfizer shall 

  
 50 

	 	
promptly assign such license to Licensee (to the extent allowed under such license), or if not, Pfizer shall continue to Manufacture or have Manufactured the Products for a period of not less
than [***], including, at Licensee’s request, a reasonable stock build. Licensee shall pay to Pfizer [***] of manufacturing associated with inventory and Compound and Product received by Licensee pursuant to this
Section 15.4.1(c)(v). 

  

	 	(vi)	 Third Party Agreements. At Licensee’s request, to the extent Pfizer is able to do so, Pfizer shall
assign to Licensee (or its designee) any agreements with Third Parties with respect to the Development, Commercialization and Manufacture of the Compounds and Products. With respect to Third Party agreements that Pfizer is not able to assign to
Licensee, Pfizer shall cooperate to give Licensee the benefit of such contracts for a reasonable transitional period. 

  

	 	15.4.2	 Termination of Terminated Products or Terminated Territory by Licensee for Cause. In the event
that Licensee terminates this Agreement with respect to [***] or a Terminated Territory, as applicable, pursuant to Section 15.2 (but not in the case of any termination of this Agreement in its entirety), the following
shall apply: 

  

	 	(a)	 Rights and Obligations. Except as otherwise provided herein, including pursuant to
Section 15.5, this Agreement shall automatically be deemed to be amended to exclude the rights and obligations of Pfizer hereunder with respect to such Terminated Products or Terminated Territory, as applicable, including,
for clarity, all licenses granted to Pfizer hereunder with respect to such Terminated Products or Terminated Territory, as applicable. 

  

	 	(b)	 Licenses. All rights and licenses granted to Licensee hereunder shall become fully paid-up, irrevocable and perpetual with respect to such Terminated Products or Terminated Territory, as applicable. 

  

	 	(c)	 Transition. During the notice period provided in Section 15.2, at
Licensee’s sole option, Licensee shall prepare and the Parties shall negotiate a transition plan that will include, at a minimum, a plan for accomplishing the activities described in this Section 15.4.2(c).

  
 51 

	 	(i)	 Continued Exploitation. At Licensee’s request [***], Pfizer shall continue on-going Exploitation with respect to such Terminated Products or Terminated Territory, as applicable, for a mutually agreed-upon period following the termination of this Agreement with respect to the Terminated
Products or Terminated Territory, as applicable, which period shall not be less than [***] unless otherwise agreed to by the Parties. For avoidance of doubt, if Licensee chooses not to continue a Clinical Trial initiated by Pfizer, [***] of winding
down such Clinical Trial, including compliance with any ethical or other requirements imposed by an applicable Regulatory Authority. 

  

	 	(ii)	 Technology Transfer. At Licensee’s request, Pfizer shall make available to Licensee all currently
available records and data which exist and are Controlled by Pfizer with respect to such Terminated Products or Terminated Territory, as applicable, as of the effective date of termination and are necessary or useful for Licensee to continue
Commercializing and Exploiting such Terminated Products in the Field in the Territory or the Products in the such Terminated Territory, as applicable. 

  

	 	(iii)	 Regulatory Matters. At Licensee’s request, Pfizer shall transfer and assign to Licensee (or its
designee) all Regulatory Approvals and Regulatory Filings held by Pfizer with respect to such Terminated Products or Terminated Territory, as applicable, provided that if such transfer and assignment is not permitted by the applicable
Regulatory Authority, Pfizer shall permit Licensee to cross-reference and rely upon such Regulatory Approvals and Regulatory Filings. Pfizer shall make available to Licensee copies of all regulatory documentation and records related to such
Terminated Products or Terminated Territory, as applicable, including information contained in the regulatory and safety databases. The Parties shall cooperate to ensure the prompt transition of regulatory responsibilities with respect to such
Terminated Products or Terminated Territory, as applicable, from Pfizer to Licensee. 

  

	 	(iv)	 Trademarks. Licensee shall have, and Pfizer does hereby grant to Licensee, a fully paid-up, royalty-free, worldwide (except in the event that Licensee terminates this Agreement with respect to a Terminated Territory, and such Terminated Territory is in the ROW or Japan, in which case, such license
shall be solely for the Terminated Territory), transferable, sublicensable, perpetual and irrevocable license to use the Pfizer Product Trademarks 

  
 52 

	 	
associated with the Terminated Products, or all Products with respect to the Terminated Territory, as applicable, if any, solely for the purpose of using, Developing, Commercializing and
Manufacturing with respect to the Terminated Products or Terminated Territory, as applicable. Licensee shall have a transitional license to use Pfizer’s Trademarks and promotional materials solely for the purpose of using, Developing,
Commercializing and Manufacturing the Terminated Products, or all Products with respect to the Terminated Territory, as applicable. 

  

	 	(v)	 Inventory and Supply. At Licensee’s request, Pfizer shall transfer to Licensee (or its designee)
all Compound and Product, components and in-process inventory held by Pfizer with respect to the Terminated Products or Terminated Territory, as applicable, as of such date of termination, if any. At
Licensee’s request, if Pfizer has licensed to a CMO to Manufacture a Terminated Product, or any Products with respect to the Terminated Territory, as applicable, and if Pfizer is able to do so, Pfizer shall promptly assign such license to
Licensee, or if not, Pfizer shall continue to Manufacture or have Manufactured such Terminated Product or any Products with respect to the Terminated Territory, as applicable, for a period of not less than [***], including, at Licensee’s
request, a reasonable stock build. Licensee shall pay to Pfizer [***] of manufacturing associated with inventory and Compound and Product received by Licensee pursuant to this Section 15.4.2(c)(v). 

 

	 	(vi)	 Third Party Agreements. At Licensee’s request, to the extent Pfizer is able to do so, Pfizer shall
assign to Licensee (or its designee) any agreements with Third Parties with respect to such Terminated Products or Terminated Territory, as applicable. With respect to Third Party agreements that Pfizer is not able to assign to Licensee, Pfizer
shall cooperate to give Licensee the benefit of such contracts for a reasonable transitional period. 

  

	 	15.4.3	 Termination in its Entirety by Pfizer for Cause; Termination in its Entirety for Convenience by
Licensee. In the event that (i) Pfizer terminates this Agreement in its entirety pursuant to Section 15.2, or (ii) Licensee terminates this Agreement in its entirety pursuant to
Section 15.3, the following shall apply: 

  
 53 

	 	(a)	 Rights and Obligations. Except as otherwise provided herein, including pursuant to
Section 15.5, all rights and obligations of each Party hereunder shall cease, including, for clarity all licenses granted to Licensee hereunder. 

 

	 	(b)	 Licenses. Licensee hereby grants to Pfizer and its Affiliates, an exclusive, sublicensable,
royalty-free, full paid-up, irrevocable, worldwide and perpetual right and license, with the right to assign and grant sublicenses, under the Developed IP, as it exists as of the effective date of termination,
to Exploit the Products in the Field in the Territory. 

  

	 	(c)	 Transition. During the notice period provided in Section 15.2 and
Section 15.3, as applicable to such termination, at Pfizer’s sole option, Pfizer shall prepare and the Parties shall negotiate a transition plan that will include, at a minimum, a plan for accomplishing the activities
described in this Section 15.4.3(c). 

  

	 	(i)	 Continued Exploitation. At Pfizer’s request [***], Licensee shall continue on-going Exploitation for a mutually agreed-upon period following the termination of this Agreement, which period shall not be less than [***] unless otherwise agreed to by the Parties. For avoidance of doubt, if
Pfizer chooses not to continue a Clinical Trial initiated by Licensee, [***] of winding down such Clinical Trial, including compliance with any ethical or other requirements imposed by an applicable Regulatory Authority. 

 

	 	(ii)	 Technology Transfer. At Pfizer’s request, Licensee shall make available to Pfizer all currently
available records and data which exist and are Controlled by Licensee as of the effective date of termination and are necessary or useful for Pfizer to continue Exploiting Compounds and Products in the Field in the Territory. 

 

	 	(iii)	 Regulatory Matters. At Pfizer’s request, Licensee shall transfer and assign to Pfizer (or its
designee) all Regulatory Approvals and Regulatory Filings held by Licensee with respect to Compounds and Products, provided that if such transfer and assignment is not permitted by the applicable Regulatory Authority, Licensee shall permit
Pfizer to cross-reference and rely upon such Regulatory Approvals and Regulatory Filings. Licensee shall make available to Pfizer copies of all regulatory documentation and records related to Compounds and Products, including information contained
in the regulatory and safety databases. The Parties shall cooperate to ensure the prompt transition of regulatory responsibilities for Compounds and Products from Licensee to Pfizer. 

  
 54 

	 	(iv)	 Trademarks. Pfizer shall have, and Licensee does hereby grant to Pfizer, a fully paid-up, royalty-free, worldwide, transferable, sublicensable, perpetual and irrevocable license to use the Licensee Product Trademarks solely for the purpose of using, Developing, Commercializing and Manufacturing
the Products in the U.S. and Japan. Pfizer shall have a transitional license to use Licensee’s Trademarks and promotional materials solely for the purpose of using, Developing, Commercializing and Manufacturing the Products.

  

	 	(v)	 Inventory and Supply. At Pfizer’s request, Licensee shall transfer to Pfizer (or its designee) all
Compound and Product, components and in-process inventory held by Licensee with respect to the Manufacture of Compounds and Products as of such date of termination. At Pfizer’s request, if Licensee has
sublicensed to a CMO to Manufacture the Compounds or Products, Licensee shall promptly assign such sublicense to Pfizer, or if not, Licensee shall continue to Manufacture or have Manufactured the Products for a period of not less than [***],
including, at Pfizer’s request, a reasonable stock build. Pfizer shall pay to Licensee [***] of manufacturing associated with inventory and Compound and Product received by Pfizer pursuant to this Section 15.4.3(c)(v).

  

	 	(vi)	 Third Party Agreements. At Pfizer’s request, to the extent Licensee is able to do so, Licensee
shall assign to Pfizer (or its designee) any agreements with Third Parties with respect to the Development, Commercialization and Manufacture of the Compounds and Products. With respect to Third Party agreements that Licensee is not able to assign
to Pfizer, Licensee shall cooperate to give Pfizer the benefit of such contracts for a reasonable transitional period. 

  

	 	15.4.4	 Termination Terminated Products or a Terminated Territory by Pfizer for Cause. In the event that Pfizer
terminates this Agreement with respect to all [***] or a Terminated Territory, as applicable, pursuant to Section 15.2 (but not in the case of any termination of this Agreement in its entirety), the following shall apply:

  
 55 

	 	(a)	 Rights and Obligations. Except as otherwise provided herein, including pursuant to
Section 15.5, this Agreement shall automatically be deemed to be amended to exclude the rights and obligations of Licensee hereunder with respect to such Terminated Products or Terminated Territory, as applicable, including
for clarity, all licenses granted to Licensee hereunder with respect to such Terminated Products or Terminated Territory, as applicable. 

  

	 	(b)	 Licenses. 

  

	 	(i)	 All rights and licenses granted to Pfizer hereunder shall become fully
paid-up, irrevocable and perpetual with respect to such Terminated Products or Terminated Territory, as applicable. 

  

	 	(ii)	 If Pfizer terminates this Agreement with respect to Terminated Products, Licensee hereby grants to Pfizer and
its Affiliates, an exclusive, sublicensable, royalty-free, full paid-up, irrevocable, and perpetual right and license, with the right to assign and grant sublicenses, under the Developed IP, as it exists as of
the effective date of termination, to Exploit the Terminated Products in the Field in the Territory. 

  

	 	(iii)	 If Pfizer terminates this Agreement with respect to a Terminated Territory, Licensee hereby grants to Pfizer
and its Affiliates, an exclusive, sublicensable, royalty-free, full paid-up, irrevocable, and perpetual right and license, with the right to assign and grant sublicenses, under the Developed IP, as it exists
as of the effective date of termination, to Exploit the Terminated Products in the Field in the Terminated Territory. 

  

	 	(c)	 Transition. During the notice period provided in Section 15.2, at
Pfizer’s sole option, Pfizer shall prepare and the Parties shall negotiate a transition plan that will include, at a minimum, a plan for accomplishing the activities described in this Section 15.4.4(c).

  

	 	(i)	 Continued Exploitation. At Pfizer’s request [***], Licensee shall continue on-going Exploitation with respect to such Terminated Products or Terminated Territory, as applicable, for a mutually agreed-upon period following the termination of this Agreement with respect to the Terminated
Products or Terminated Territory, as applicable, which period shall not be less than [***] unless otherwise agreed to by the Parties. For avoidance of doubt, if Pfizer chooses not to continue a Clinical Trial initiated by Licensee pursuant to this
Section 15.4.4(c)(i), [***] of winding down such Clinical Trial, including compliance with any ethical or other requirements imposed by an applicable Regulatory Authority. 

  
 56 

	 	(ii)	 Technology Transfer. At Pfizer’s request, Licensee shall make available to Pfizer all currently
available records and data which exist and are Controlled by Licensee with respect to such Terminated Products or Terminated Territory, as applicable, as of the effective date of termination, and are necessary or useful for Pfizer to continue
Exploiting such Terminated Products in the Field in the Territory or the Products in the such Terminated Territory, as applicable. 

  

	 	(iii)	 Regulatory Matters. At Pfizer’s request, Licensee shall transfer and assign to Pfizer (or its
designee) all Regulatory Approvals and Regulatory Filings held by Licensee with respect to such Terminated Products or Terminated Territory, as applicable, provided that if such transfer and assignment is not permitted by the applicable
Regulatory Authority, Licensee shall permit Pfizer to cross-reference and rely upon such Regulatory Approvals and Regulatory Filings. Licensee shall make available to Pfizer copies of all regulatory documentation and records related to such
Terminated Products or Terminated Territory, as applicable, including information contained in the regulatory and safety databases. The Parties shall cooperate to ensure the prompt transition of regulatory responsibilities with respect to such
Terminated Products or Terminated Territory, as applicable, from Licensee to Pfizer. 

  

	 	(iv)	 Trademarks. Pfizer shall have, and Licensee does hereby grant to Pfizer, a fully paid-up, royalty-free, worldwide (except in the event that Pfizer terminates this Agreement with respect to a Terminated Territory, and such Terminated Territory is in the U.S. or Japan, in which case, such license
shall be solely for the Terminated Territory) transferable, sublicensable, perpetual and irrevocable license to use the Licensee Product Trademarks associated with the Terminated Products, or all Products with respect to the Terminated Territory, as
applicable, solely for the purpose of using, Developing, Commercializing and Manufacturing with respect to the Terminated Products or Terminated Territory, as applicable. Pfizer shall have a transitional license to use Licensee’s Trademarks and
promotional materials solely for the purpose of using, Developing, Commercializing and Manufacturing the Terminated Products, or all Products with respect to a Terminated Territory, as applicable. 

  
 57 

	 	(v)	 Inventory and Supply. At Pfizer’s request, Licensee shall transfer to Pfizer (or its designee) all
Compound and Product, components and in-process inventory held by Licensee with respect to the Terminated Products or Terminated Territory, as applicable, as of such date of termination. At Pfizer’s
request, if Licensee has sublicensed to a CMO to Manufacture a Terminated Product, or any Products with respect to the Terminated Territory, as applicable, Licensee shall promptly assign such sublicense to Pfizer, or if not, Licensee shall continue
to Manufacture or have Manufactured with respect to such Terminated Product or any Products with respect to the Terminated Territory, for a period of not less than [***], including, at Pfizer’s request, a reasonable stock build. Pfizer shall
pay to Licensee [***] of manufacturing associated with inventory and Compound and Product received by Pfizer pursuant to this Section 15.4.4(c)(v). 

 

	 	(vi)	 Third Party Agreements. At Pfizer’s request, to the extent Licensee is able to do so, Licensee
shall assign to Pfizer (or its designee) any agreements with Third Parties with respect to the Development, Commercialization and Manufacture of the Terminated Products or Terminated Territory, as applicable. With respect to Third Party agreements
that Licensee is not able to assign to Pfizer, Licensee shall cooperate to give Pfizer the benefit of such contracts for a reasonable transitional period. 

  

	 	15.5	 Survival. Expiration or termination of this Agreement shall not relieve the Parties of any
obligation accruing hereunder prior to such expiration or termination. Without limiting the foregoing, (a) the provisions of Sections 1 (Definitions), 8 (Records; Audit Rights), 9.1
(Pre-existing IP), 11 (Confidentiality), 13 (Indemnification), 14 (Limitation of Liability) 15.4 (Effects of Termination), 15.5 (Survival), 17 (Licensee Insurance) and
18 (General Provisions) shall survive expiration or termination of this Agreement and [***]. If this Agreement is terminated with respect to a Terminated Product or Terminated Territory, as applicable, but not in its entirety, then following
such termination the foregoing provisions of this Agreement shall remain in effect with respect to such Terminated Product or Terminated Territory (to the extent they would survive and apply in the event the Agreement expires or is terminated in its
entirety or as otherwise necessary for any of Pfizer and its Affiliates and its and their sublicensees to exercise their rights to such Terminated Product or Terminated Territory) and all provisions not surviving in accordance with the foregoing
shall terminate upon termination of this Agreement with respect to the Terminated Product or Terminated Territory and be of no further force and effect. 

  
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	 	15.6	 365(n) Rights. All rights and licenses now or hereafter granted to Licensee under or pursuant to
this Agreement, including Sections 2.1.1 and 2.1.2, are rights to “intellectual property” as defined in Section 101(35A) of Title 11 of the United States Bankruptcy Code (the “Bankruptcy Code”). Pfizer
hereby grants to Licensee a right of access and to obtain possession of and to benefit from the Licensed Know-How, which constitute “embodiments” of intellectual property pursuant to
Section 365(n) of the Bankruptcy Code. Pfizer agrees not to interfere with Licensee’s exercise of rights and licenses to intellectual property licensed hereunder and embodiments thereof in accordance with this Agreement and agrees to use
commercially reasonable efforts to assist Licensee to obtain such intellectual property and embodiments thereof in the possession or control of Affiliates or Third Parties as reasonably necessary or desirable for Licensee to exercise such rights and
licenses in accordance with this Agreement. The Parties acknowledge and agree that all payments by Licensee to Pfizer under this Agreement, other than U.S. Sales Milestone Payments and Licensee Royalties, do not constitute “royalties”
within the meaning of Bankruptcy Code § 365(n) or relate to licenses of intellectual property hereunder. Conditioned upon satisfaction of the requirements of Section 365(b) of the Bankruptcy Code, Pfizer hereby consents to assumption of
this Agreement in a case filed by or against Licensee under the Bankruptcy Code. 

  

	16.	 PUBLICITY; PUBLICATIONS. 

 

	 	16.1	 Use of Names. Subject to Pfizer’s rights pursuant to
Section 15.4.3(c)(iv), neither Party (nor any of its Affiliates or agents) shall use the registered or unregistered Trademarks of the other Party or its Affiliates in any press release, publication or other form of
promotional disclosure without the prior written consent of the other Party in each instance; provided, however, that Licensee and any of its Affiliates or sublicensees may state publicly that Licensee has received, or been sublicensed
under, a license from Pfizer to Exploit the Compounds and Products. 

  

	 	16.2	 Press Releases. The Parties acknowledge that one or both Parties, either singly or jointly, may
desire to publish one or more press releases relating to this Agreement, the rights granted hereunder, and developments made thereto. However, each Party agrees not to issue any press release or other public statement, whether written, electronic,
oral or otherwise, disclosing the existence of this Agreement, the terms hereof or any information relating to this Agreement without the prior written consent of the other Party, such consent not to be unreasonably withheld, conditioned or delayed;
provided that a Party desiring to make such public disclosure may issue such press release or public announcement without such prior written consent by the other Party if (a) the entire contents of such press release or public
announcement have previously been made public other than through a breach of this Agreement by such Party, and (b) such press release or public 

  
 59 

	 	
announcement does not materially differ from a previously issued press release or other publicly available information. Neither Party will be prevented from complying with any duty of disclosure
it may have pursuant to Applicable Law or the rules of any recognized stock exchange so long as the disclosing Party provides the other Party at least [***] prior written notice to the extent practicable and only discloses information to the extent
required by Applicable Law or the rules of any recognized stock exchange. 

  

	 	16.3	 Publications. During the Term, subject to the final sentence of this
Section 16.3, Licensee shall have the sole right to make any academic, scientific or medical publication or public presentation related to the Compounds and Products; provided that written copies of such proposed
publication or presentation shall be submitted to Pfizer for review no later than [***] before submission for publication or presentation (the “Review Period”). [***] 

 

	17.	 INSURANCE. 

 

	 	17.1	 Licensee Insurance Requirements. Licensee will maintain during the Term and until the later of
(a) [***] after termination or expiration of this Agreement, or (b) the date that all statutes of limitation covering claims or suits that may be instituted for personal injury based on the sale or use of the Products have expired, commercial
general liability insurance from a minimum “A-” AM Best rated insurance company, including contractual liability and product liability or clinical trials, if applicable, with coverage limits of not
less than [***] U.S. Dollars per occurrence and [***] U.S. Dollars in the aggregate. Licensee has the right to provide the total limits required by any combination of primary and umbrella/excess coverage. The minimum level of insurance set forth
herein shall not be construed to create a limit on Licensee’s liability hereunder. Such policies shall name Pfizer and its Affiliates as additional insured via form CG20101185 or its equivalent (usually for US, Canada and Puerto Rico exposures)
or indemnify Pfizer and its Affiliates, as principal (usually for rest of world exposures) and provide a waiver of subrogation in favor of Pfizer and its Affiliates. Licensee shall also maintain statutory workers’ compensation and employers
liability with a minimum of [***] U.S. Dollars per occurrence. Such insurance policies shall be primary and non-contributing with respect to any other similar insurance policies available to Pfizer or its
Affiliates. Any deductibles or retentions for such insurance shall be assumed by Licensee. 

  

	 	17.2	 Licensee Policy Notification. Licensee shall provide Pfizer with certified copies of such policies or
original (electronic is acceptable) certificates of insurance evidencing such insurance (a) prior to execution by both Parties of this Agreement, and (b) the earlier of annually thereafter or prior to expiration of any one coverage.
Licensee shall provide that Pfizer shall be given at least [***] written notice prior to cancellation, termination or any material change to restrict the coverage or reduce the limits afforded. 

  
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	 	17.3	 Pfizer Insurance Requirements. Pfizer, as sponsor of the [***] and [***], will
maintain during the Term and until the later of (a) [***] after termination or expiration of this Agreement, or (b) the date that all statutes of limitation covering claims or suits that may be instituted for personal injury based on the
sale or use of the Products have expired, commercial general liability insurance from a minimum “A-” AM Best rated insurance company, including contractual liability and product liability or clinical
trials, if applicable, with coverage limits of not less than [***] U.S. Dollars per occurrence and [***] U.S. Dollars in the aggregate. Pfizer has the right to provide the total limits required by any combination of primary and
umbrella/excess coverage. The minimum level of insurance set forth herein shall not be construed to create a limit on Pfizer’s liability hereunder. Such policies shall name Licensee and its Affiliates as additional insured via form CG20101185
or its equivalent (usually for US, Canada and Puerto Rico exposures) or indemnify Licensee and its Affiliates, as principal (usually for rest of world exposures) and provide a waiver of subrogation in favor of Licensee and its Affiliates. Pfizer
shall also maintain statutory workers’ compensation and employers liability with a minimum of [***] U.S. Dollars per occurrence. Such insurance policies shall be primary and non-contributing with respect
to any other similar insurance policies available to Licensee or its Affiliates. Any deductibles or retentions for such insurance shall be assumed by Pfizer. Pfizer’s insurance obligations can be met through a combination of insurance
and/or self-insurance. 

  

	 	17.4	 Pfizer Policy Notification. Pfizer shall provide Licensee with original (electronic is
acceptable) certificates of insurance evidencing such insurance (a) prior to execution by both Parties of this Agreement, and (b) the earlier of annually thereafter or prior to expiration of any one coverage. Pfizer shall provide that
Licensee shall be given at least [***] written notice prior to cancellation, termination or any material change to restrict the coverage or reduce the limits afforded. 

 

	18.	 GENERAL PROVISIONS. 

 

	 	18.1	 Assignment. For purposes of this Section 18.1, any Change of Control
shall be deemed an assignment. Neither Party may assign its rights and obligations under this Agreement without the other Party’s prior written consent, except that: (a) either Party may assign to a Third Party such Party’s rights to
receive some or all of the Fees payable hereunder, (b) either Party may assign its rights and obligations under this Agreement or any part hereof to one or more of its Affiliates without the consent of other Party, provided that Licensee
shall not assign all or substantially all of its rights and obligations hereunder to one or more of its Affiliates (other than Priovant Holdings, Inc. or any direct or indirect wholly owned subsidiary of Priovant Holdings, Inc.) without the prior
written consent of Pfizer; and (c) either Party may assign this Agreement in connection with a Change of Control of such Party. The assigning Party shall provide the other Party with prompt written notice of any such assignment. Any permitted
assignee pursuant to clauses (b) and (c) above shall assume all obligations of its assignor under this Agreement, and no permitted assignment shall relieve the assignor of liability for its obligations hereunder. Any attempted assignment in
contravention of the foregoing shall be void. 

  
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	 	18.2	 Severability. Should one or more of the provisions of this Agreement become void or unenforceable
as a matter of law, then such provision will be ineffective only to the extent of such prohibition or invalidity, without invalidating the remainder of this Agreement, and the Parties agree to substitute a valid and enforceable provision therefor
which, as nearly as possible, achieves the desired economic effect and mutual understanding of the Parties under this Agreement. 

  

	 	18.3	 Governing Law; Dispute Resolution 

 

	 	18.3.1	 This Agreement shall be governed by and construed in all respects in accordance with the internal laws
of the State of New York, as such laws are applied to agreements among New York residents entered into and performed entirely within New York, without giving effect to
conflict-of-law principles thereof. 

  

	 	18.3.2	 With support from the Alliance Managers, the Parties shall negotiate in good faith and use reasonable
efforts to settle any dispute, controversy or action arising from or related to this Agreement or the breach thereof. Subject to Section 18.3.8, in the event that the Parties cannot resolve such dispute, controversy or
action within a period of [***] from when the dispute, controversy or action is first identified in writing by the Party raising or asserting such dispute, controversy or action, then the matter shall be referred to designated senior executives of
the Parties for resolution by the sending of a notice of dispute(s) for executive resolution (a “Notice of Dispute(s) for Executive Resolution”). The designated senior executives shall endeavor to meet in person or by means of
telephone conference, video conference or similar communications equipment by means of which all Persons participating in the meeting can hear and speak to each other, and where such participation by the Parties’ designated senior executives
shall constitute presence in person at the meeting, within [***] following transmittal of the Notice of Dispute(s) for Executive Resolution. Each Party shall be entitled to name substitute senior executives upon written notice to the other Party.
The foregoing duties may be delegated to the extent the person delegated with such duties is duly authorized to enter into the foregoing resolution without seeking any additional approval within the respective Party. 

 

	 	18.3.3	 Except as expressly set forth in Section 18.3.8, if the Parties do not fully
settle any dispute, controversy or action referred to the senior executives of the Parties within [***] of it being referred to them, and a Party wishes to pursue the matter, then such dispute, controversy or action that is not an Excluded Action
shall be finally resolved by binding arbitration administered by the American Arbitration Association (“AAA”) pursuant to AAA’s Commercial Arbitration Rules then in effect. 

  
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	 	18.3.4	 The arbitration shall be conducted by a panel of three (3) neutral arbitrators, each of whom shall
have significant legal or business experience in the pharmaceutical industry, and none of whom shall be a current or former employee or director, or a current significant shareholder, of either Party or any of their respective Affiliates or
sublicensees; and within [***] after initiation of arbitration, each Party shall select one (1) person to act as arbitrator and the two (2) Party-selected arbitrators shall select a third (3rd) arbitrator within [***] of their appointment.
If the arbitrators selected by the Parties are unable or fail to agree upon the third (3rd) arbitrator, then on the [***] after the initiation of arbitration, the two (2) Party-selected arbitrators shall make a written request to AAA to appoint
a third (3rd) arbitrator. AAA shall appoint such third (3rd) arbitrator within [***] of being notified by the two (2) Party-selected arbitrators. The place of arbitration shall be New York, New York, and all proceedings and communications shall
be in English. The award rendered by the arbitrators shall be final, binding and non-appealable, and judgment may be entered upon it in any court of competent jurisdiction. 

 

	 	18.3.5	 Either Party may apply to the arbitrators for interim injunctive relief until the arbitration award is
rendered or the controversy is otherwise resolved. Either Party has the right to file an early dispositive motion seeking a determination on the issue of whether a material breach has occurred under Section 15.2, and the
arbitrators will promptly rule on such motion. The arbitrators’ authority to award punitive or any other type of damages not measured by a Party’s compensatory damages shall be subject to the limitation set forth in
Section 14.1. [***] 

  

	 	18.3.6	 Except to the extent necessary to confirm or enforce an award or as may be required by Applicable Law,
neither Party nor an arbitrator may disclose the existence, content or results of an arbitration without the prior written consent of the other Party. In no event shall an arbitration be initiated after the date when commencement of a legal or
equitable action based on the dispute, controversy or action would be barred by the applicable statute of limitations in New York. 

  

	 	18.3.7	 The term “Excluded Action” means a dispute, controversy or action that concerns
(i) the construction, scope, validity, enforceability, inventorship or infringement, misappropriation or other violation of any Intellectual Property Rights; or (ii) any antitrust, anti-monopoly or competition law or regulation, whether or
not statutory. 

  

	 	18.3.8	 Either Party may bring an action in any court of competent jurisdiction to resolve any Excluded Action,
and no Excluded Action shall be subject to arbitration pursuant to Sections 18.3.3 or 18.3.4. Any Excluded Action brought by either Party pursuant to this Section 18.3.8 shall be venued exclusively in the
United States District Court for the Southern District of New York (“SDNY”), or if the SDNY does not have the jurisdiction to hear such Excluded Action, in a state court located in New York county, and each Party expressly and
irrevocably consents and submits to the jurisdiction of such courts having appropriate jurisdiction in connection with any such legal action. 

  
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	 	18.3.9	 EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING FROM OR
RELATED TO THIS AGREEMENT OR THE BREACH THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT ARISE FROM OR RELATE TO THIS
AGREEMENT OR THE BREACH THEREOF, INCLUDING CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE
PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS
FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 

  

	 	18.4	 Equitable Relief. The Parties agree that irreparable damage would occur in the event that any of
the provisions of Section 3 or Section 11, in each case, is not performed in accordance with its specific terms of this Agreement or is otherwise breached. It is accordingly agreed that either
Party shall be entitled to an injunction or injunctions to prevent breaches of Section 3 or Section 11 and to enforce specifically the terms and provisions of such section of this Agreement in any
court of the United States or any state having jurisdiction, this being in addition to any other remedy to which such Party is entitled at law or in equity. Each Party hereby waives (a) any requirement that the other Party post a bond or other
security as a condition for obtaining any such relief and (b) any defenses in any action for specific performance, including the defense that a remedy at law would be adequate. The Parties acknowledge and agree that damages, to the extent
incurred by and awarded to, a Party are an appropriate remedy for any breach or violation of any other provision of this Agreement and that the Parties do not intend for any other provision of this Agreement to be specifically enforceable.

  

	 	18.5	 Force Majeure. Except with respect to delays or nonperformance caused by the negligent or
intentional act or omission of a Party, any delay or nonperformance by such Party (other than payment obligations under this Agreement) will not be considered a breach of this Agreement to the extent such delay or nonperformance is caused by acts of
God, natural disasters, acts of any Governmental Authority or civil or military authority, fire, floods, epidemics, quarantine, energy crises, war or 

  
 64 

	 	
riots or any other cause outside of the reasonable control of such Party (each, a “Force Majeure Event”), provided that the Party affected by such Force Majeure Event will
promptly begin or resume performance as soon as reasonably practicable after the event has abated. If the Force Majeure Event prevents a Party from performing any of its obligations under this Agreement for three hundred sixty five (365) days
or more, then the other Party may terminate this Agreement immediately upon written notice to the non-performing Party. 

  

	 	18.6	 Waivers and Amendments. The failure of any Party to assert a right hereunder or to insist upon
compliance with any term or condition of this Agreement shall not constitute a waiver of that right or excuse a similar subsequent failure to perform any such term or condition by the other Party. No waiver shall be effective unless it has been
given in writing and signed by the Party giving such waiver. No provision of this Agreement may be amended or modified other than by a written document signed by authorized representatives of each Party. 

 

	 	18.7	 Relationship of the Parties. Nothing contained in this Agreement shall be deemed to constitute a
partnership, joint venture, or legal entity of any type between Pfizer and Licensee, or to constitute one Party as the agent of the other. Moreover, each Party agrees not to construe this Agreement, or any of the transactions contemplated hereby, as
a partnership, joint venture, employment, franchise, agency or fiduciary or similar relationship for any tax purposes. Each Party shall act solely as an independent contractor, and nothing in this Agreement shall be construed to give any Party the
power or authority to act for, bind, or commit the other Party. 

  

	 	18.8	 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the Parties
hereto and their respective successors and permitted assigns. 

  

	 	18.9	 Notices. All notices, consents, waivers, and other
communications required or permitted to be given hereunder shall in all cases be delivered by email (with receipt of such email acknowledged by a non-automated response by the applicable recipient within two
(2) Business Days of receipt, or, in the event that receipt is not so acknowledged by the applicable recipient, with delivery by an internationally recognized courier service of a confirmatory hardcopy without undue delay) and shall be deemed
given when sent, provided that (a) there is no “bounce back” message and (b) such email is sent on a Business Day prior to 6:00 pm local time of the recipient, and on the next Business Day if sent at any other time, but
may, as a second method of delivery, also be delivered (i) by personal delivery or (ii) by an internationally recognized overnight courier service, to the applicable address set forth below, unless another address has been previously
specified in writing by such Party in the manner set forth above. 

 If to Pfizer: 

Pfizer Inc. 
 [***] 

  
 65 

 If to Licensee: 

Priovant, Inc. 
 [***] 

If to Roivant: 
 Roivant
Sciences Ltd. 
 [***] 
  

	 	18.10	 Further Assurances. Licensee and Pfizer hereby covenant and agree without the necessity of any further
consideration, to execute, acknowledge and deliver any and all such other documents and take any such other action as may be reasonably necessary or appropriate to carry out the intent and purposes of this Agreement. 

 

	 	18.11	 No Third Party Beneficiary Rights. This Agreement is not intended to and shall not be construed to give
any Third Party any interest or rights (including any third party beneficiary rights) with respect to or in connection with any agreement or provision contained herein or contemplated hereby, except for (a) the provisions of
Section 13, which shall be for the benefit of the Licensee Indemnitees and the Pfizer Indemnitees, (b) the provisions of Section 18.1, which shall be for the benefit of the Persons
contemplated thereby, and (c) this Section 18.11 in respect of the sections set forth under the foregoing clauses (a) and (b). 

 

	 	18.12	 Entire Agreement; Confidentiality Agreement. 

 

	 	18.12.1	 This Agreement, together with its Schedules, sets forth the entire agreement and understanding of the
Parties as to the subject matter hereof and supersedes all proposals, oral or written, and all other prior communications between the Parties with respect to such subject matter, including the CDA. The Parties acknowledge and agree that, as of the
Effective Date, all Confidential Information (as defined in the CDA) disclosed by Pfizer or its Affiliates pursuant to the CDA shall be considered Pfizer’s Confidential Information and subject to the terms set forth in this Agreement.

  

	 	18.12.2	 In the event of any conflict between a material provision of this Agreement and any Schedule hereto, the
Agreement shall control. 

  

	 	18.13	 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed
an original, but all of which together shall constitute one and the same instrument. The Parties agree that execution of this Agreement by industry standard electronic signature software or by exchanging executed signature pages in .pdf format via e-mail shall have the same legal force and effect as the exchange of original signatures, and that in any proceeding arising under or related to this Agreement, each Party hereby waives any right to raise any
defense or waiver based upon execution of this Agreement by means of such electronic signatures or maintenance of the executed agreement electronically. 

  
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	 	18.14	 Cumulative Remedies. No remedy referred to in this Agreement is intended to be exclusive, but each shall
be cumulative and in addition to any other remedy referred to in this Agreement or otherwise available under law. 

  

	 	18.15	 Performance by Affiliates. Any obligation of either Party under or pursuant to this Agreement may be
satisfied, met or fulfilled, in whole or in part, at such Party’s sole and exclusive option, by any Affiliate of such Party that it causes to satisfy, meet or fulfill such obligation, in whole or in part, provided that such Party shall
remain liable hereunder for the performance by its Affiliates of any such obligations. 

  

	 	18.16	 Waiver of Rule of Construction. Each Party has had the opportunity to consult with counsel in connection
with the review, drafting and negotiation of this Agreement. Accordingly, any rule of construction that any ambiguity in this Agreement shall be construed against the drafting Party shall not apply. 

[Signature pages to follow] 

  
 67 

 IN WITNESS WHEREOF, the Parties intending to be bound have caused this Agreement to be
executed by their duly authorized representatives as of the Effective Date. 
  

			
	PFIZER INC.
		
	By:	 	 /s/ John Young

	Name:	 	JOHN Young
	Title:	 	Chief Business Officer

 [Signature Page to License and Collaboration Agreement] 

 IN WITNESS WHEREOF, the Parties intending to be bound have caused this Agreement to be
executed by their duly authorized representatives as of the Effective Date. 
  

			
	PRIOVANT, INC.
		
	By:	 	 /s/ Benjamin Zimmer

	Name:	 	Benjamin Zimmer
	Title:	 	Chief Executive Officer
	
	And solely with respect to Section 11.4:
	
	ROIVANT SCIENCES LTD.
		
	By:	 	 /s/ Matt Maisak

	Name:	 	Matt Maisak
	Title:	 	Chief Operating Officer, Roivant Platforms

 [Signature Page to License and Collaboration Agreement]EX-10.38

 Exhibit 10.38 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE ROIVANT SCIENCES LTD. (THE
“COMPANY”) HAS DETERMINED THAT THE INFORMATION (I) IS NOT MATERIAL AND (II) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED. 

FIRST AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT 

THIS FIRST AMENDMENT TO LICENSE AND COLLABORATION AGREEMENT (the “First Amendment”) is dated as of the 10th day of June, 2022
(the “First Amendment Effective Date”), by and between Pfizer Inc., a corporation organized and existing under the laws of Delaware with offices at [***] (“Pfizer”), and Priovant Therapeutics, Inc., formerly known
as Priovant, Inc., a corporation organized and existing under the laws of Delaware with offices at [***] (“Licensee”). Licensee and Pfizer may be individually referred to as a “Party” and collectively referred to as
the “Parties”. Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to such terms in the Original Agreement (as defined below). 

WHEREAS, the Parties entered into a License and Collaboration Agreement dated September 13, 2021 (the “Original
Agreement,” as amended by this First Amendment, the “Agreement”); and 
 WHEREAS, the Parties have agreed to amend
the[***] to [***]; and 
 WHEREAS, the Parties desire to amend certain portions of Section 5.9.2 of the Original Agreement relating to
the [***], and certain related definitional provisions, in light of the planned amendment to the [***]; 
 NOW, THEREFORE, in consideration
of the mutual agreements, provisions and covenants contained in this First Amendment, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, hereby
agree as follows: 
  

	1.	 The first sentence of the first paragraph of Section 5.9.2 of the Original Agreement is hereby amended by
deleting the text beginning with “(a)” and ending before “(b)” and inserting in lieu thereof the following: 

“[***]”. 
  

	2.	 The Original Agreement is hereby further amended by deleting Section 5.9.2(b) in its entirety. In
addition, Section 1.76, Section 1.153 and Section 1.154 of the Original Agreement are each hereby deleted in their entirety and replaced with the following text: “Intentionally Left Blank.” 

 

	3.	 Except as set forth in this First Amendment, all terms and conditions of the Original Agreement are hereby
ratified and shall remain in full force and effect. Amendments made pursuant to this First Amendment shall be effective as of the First Amendment Effective Date. 

  
 1 

	4.	 In the event of a conflict between a provision of the Original Agreement and a provision of this First
Amendment, the provisions of this First Amendment will control to the extent of such conflict. 

  

	5.	 This First Amendment may be executed in counterparts (including by facsimile or other electronic transmission),
all of which together shall constitute an agreement binding on the Parties. 

 IN WITNESS WHEREOF, the Parties have duly
executed this First Amendment as of the First Amendment Effective Date. 
  

			
	PFIZER INC.
		
	By:	 	 /s/ Michael Vincent

	Name:	 	Michael Vincent
	Title:	 	SVP & CSO - I&I
	
	PRIOVANT THERAPEUTICS, INC.
		
	By:	 	 /s/ Benjamin Zimmer

	Name:	 	Benjamin Zimmer
	Title:	 	CEO

  
 2

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