Document:

EX-4.1

 Exhibit 4.1 

Execution Version 
 FOURTH
AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT 
 This FOURTH AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this
“Agreement”), dated as of July 5, 2018 and effective as of the Effective Time, is among (i) Thorne Holding Corp., a Delaware corporation (the “Company”), (ii) the Stockholders listed on Schedule 1
hereto (the “Initial Stockholders”), (iii) the individuals listed on Schedule 2 hereto (the “Purchasers”) and (iv) each person who shall, subsequent to the date hereof, join in and become a party to this
Agreement pursuant to, and in accordance with, Section 2(1) hereof (“Additional Stockholders” and together with the Initial Stockholders and the Purchasers, the “Stockholders”). 

WHEREAS, the Company and WestView Capital Partners II, L.P. (“WestView”), Tudor Ventures III L.P. (“Tudor”),
Diversified Natural Products, Inc. (“DNP”), Albert Czap (“Czap”), ELUS Holdings Corporation (“ELUS”), IdB Holding S.p.A, the James L. Gilbert Trust – 1994 (“Gilbert”), Monashee
Capital Master Fund L.P. and Mitsui & Co., Ltd. (“Mitsui”) are parties to that certain Third Amended and Restated Registration Rights Agreement, dated as of November 22, 2017, among the Company and the parties referred
to therein (the “Amended Agreement”); 
 WHEREAS, the undersigned Stockholders and the Company, being all of the parties
necessary to amend the Amended Agreement in accordance with the terms thereof, have agreed to amend and restate the Amended Agreement in its entirety in the form of this Agreement; 

WHEREAS, the Company, the Purchasers, WestView, Tudor, Czap, Gilbert, ELUS and DNP have entered into a Preferred Stock Purchase and Securities
Redemption Agreement (the “SPRA”), dated as of the date hereof, pursuant to which, among other things, (a) the Purchasers will purchase shares of the Company’s Series E Preferred Stock, $0.01 par value per share (the
“Series E Preferred Stock”); (b) Mitsui will exchange its outstanding shares of the Company’s Series D Preferred Stock, $0.01 par value per share (the “Series D Preferred Stock”), for newly issued shares of
Series E Preferred Stock; (c) the Company will redeem all outstanding capital stock of the Company held by WestView, Tudor, Czap and Gilbert; and (d) immediately after the consummation of the transactions described in the foregoing clauses
(b) and (c), all remaining shares of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock shall be converted into shares of Common Stock; 

WHEREAS, but for the execution and delivery of this Agreement, the Company and the Purchasers would not be willing to enter into the SPRA or
to consummate the transactions contemplated thereby, which transactions will benefit the parties; and 
 WHEREAS, the parties hereto wish to
set forth their respective rights with regard to the registration of shares of the Company’s capital stock for public sale and certain other matters relating thereto. 

 NOW, THEREFORE, the parties to this Agreement hereby agree to amend and restate the Amended
Agreement in its entirety, as set forth herein, and further agree as follows: 
 1. DEFINITIONS. For all purposes of this Agreement,
the following terms shall have the meanings set forth below: 
 “Affiliate” shall mean, with respect to any Stockholder, any
Person directly or indirectly controlling, controlled by or under direct or indirect common control with, such Stockholder and shall include, without limitation, (a) any Person who is a director or beneficial holder of more than fifty percent
(50%) of the then outstanding capital stock of (or other beneficial interest in) such Stockholder and Family Members of any such Persons, (b) any Person of which such Stockholder or an Affiliate (as defined in clause (a) above) of such
Stockholder directly or indirectly, either beneficially owns more than fifty percent (50%) of the then outstanding capital stock (or partnership interests or other shares of beneficial interest) or constitutes more than a fifty percent (50%) equity
participant, (c) any Person of which an Affiliate (as defined in clause (a) above) of such Stockholder is a general partner, director, officer or executive employee, (d) in the case of a specified Person who is an individual, Family
Members of such Person, and (e) if such Person is a limited partnership, any other limited partnership the general partner of which (or the general partner of such general partner, if such general partner is itself a partnership) is the same
individual or group of individuals that serves as the general partner of such Person (or is the general partner of such general partner, if such general partner of such Person is a partnership). 

“Common Stock” shall mean the Company’s Common Stock, par value $0.01 per share. 

“Convertible Securities” shall mean any securities exercisable for, convertible into or exchangeable for any shares of Common
Stock. 
 “Effective Time” means the Closing, as defined in the SPRA. 

“ELUS” shall have the meaning set forth in the recitals hereof. 

“Exchange Act” shall mean the United States of America Securities Exchange Act of 1934, as amended, and the rules and
regulations promulgated thereunder. 
 “Family Members” shall mean, with respect to any individual, any Related Person or
Family Trust of such individual. 
 “Family Trust” shall mean, with respect to any individual, any trust or limited
liability company created solely for the benefit of one or more of such individual’s Related Persons and controlled by such individual. 

“Person” shall mean an individual, partnership, limited liability company, corporation, association, trust, joint venture,
unincorporated organization, or any government, governmental department or agency or political subdivision thereof. 
 “Preferred
Stock” shall mean the Company’s Series E Preferred Stock. 

  
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 “Public Sale” shall mean any sale of Common Stock to the public pursuant to
a public offering registered under the Securities Act or to the public through a broker or market maker pursuant to the provisions of Rule 144 (or any successor rule) adopted under the Securities Act. 

“Registrable Securities” shall mean, without duplication: (a) all shares of Common Stock held by the Stockholders from
time to time, including shares issued or issuable upon conversion of the Preferred Stock; (b) any shares of Common Stock issued as (or issuable upon the conversion or exercise of any warrant, option, right or other security which is issued as)
a dividend or other distribution with respect to, or in exchange for or in replacement of the shares referenced in (a) above; and (c) any shares of Common Stock issuable upon the conversion or exercise of any Convertible Securities issued
pursuant to the SPRA or otherwise, and held by the Stockholders; excluding in all cases, however, any shares for which registration rights have terminated pursuant to Section 10 of this Agreement. 

“Related Persons” shall mean, with respect to any individual, such individual’s parents, siblings, spouse, children and
grandchildren. 
 “SEC” shall mean the Securities and Exchange Commission. 

“Securities Act” shall mean the Securities Act of 1933, as amended, and the rules and regulation promulgated thereunder. 

“Series A Preferred Stock” shall mean the Company’s Series A Preferred Stock, par value $0.01 per share. 

“Series B Preferred Stock” shall mean the Company’s Series B Preferred Stock, par value $0.01 per share. 

“Series C Preferred Stock” shall mean the Company’s Series C Preferred Stock, par value $0.01 per share. 

“Series D Preferred Stock” shall have the meaning set forth in the recitals hereof. 

“Series E Preferred Stock” shall have the meaning set forth in the recitals hereof. 

“SPRA” shall have the meaning set forth in the recitals hereof. 

2. REGISTRATION RIGHTS. 

(a) Demand Registration. At any time after the earlier of one hundred and eighty (180) days following the completion of a Public
Sale or five (5) years after the Effective Time, upon the written request by Stockholders owning or holding, alone or with their Affiliates, more than fifty percent (50%) of the issued and outstanding Preferred Stock (including for purposes of
this calculation any issued and outstanding shares of Common Stock issued upon conversion of shares of Preferred Stock), which such Stockholders shall, in all events, include Mitsui and Kirin, respectively, so long as

  
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Mitsui or Kirin, as applicable, owns at least fifty percent (50%) of the number of shares of Preferred Stock (including for purposes of this calculation any issued and outstanding shares of
Common Stock issued upon conversion of shares of Preferred Stock) owned by them, respectively, as of the Effective Time (subject to proportionate adjustment in the case of any stock split, reverse stock split, recapitalization, reclassification
stock dividend or other distribution with respect to such shares), requesting that the Company effect a public offering under the Securities Act of all or part of the Registrable Securities held by such Stockholders and specifying the intended
method or methods of disposition of such Registrable Securities, the Company will promptly give written notice of such requested registration to all Stockholders and will use its best efforts to effect the registration under the Securities Act, as
expeditiously as is reasonable, of: 
 (i) the Registrable Securities that the Company has been so requested to register by
such Stockholders, for disposition in accordance with the intended method of disposition stated in such request; and 
 (ii)
all other Registrable Securities that the Company has been requested to register by other Stockholders by written request delivered to the Company within 30 days after the receipt of such written notice delivered by the Company; 

all to the extent required to permit the disposition (in accordance with the intended methods thereof as aforesaid) of the Registrable Securities so to be
registered. Anything herein to the contrary notwithstanding, the Company shall not be obligated to consummate more than two (2) registrations pursuant to this Section 2(a); provided, that in each case at least
eighty percent (80%) of the Registrable Securities requested to be registered are registered and sold to the public. In connection with any underwritten offering with respect to which Stockholders shall have requested registration pursuant to this
Section 2(a), the Company shall have the right to select the lead managing underwriter (being an underwriting firm of national standing) with respect to such offering, such underwriter to be reasonably acceptable to the
Stockholders requesting the registration. Should the Stockholders requesting the registration so elect, they may select an underwriting firm of national standing which is reasonably acceptable to the Company to act as
co-lead manager of such offering. 
 (b) Incidental Registration. If at any time after the
Effective Time the Company proposes to file a registration statement under the Securities Act with respect to an offering for its own account or for the sale of equity securities of any holder of any class of equity security of the Company
(excluding the Company’s initial public offering of Common Stock, unless such first public offering includes the registration of securities for the account of other Stockholders, and excluding a registration relating solely either to the sale
of securities to employees of the Company pursuant to a stock purchase, stock option or similar plan, or a merger, recapitalization or reorganization), the Company shall promptly give each Stockholder written notice of such registration at least
thirty (30) days prior to the anticipated filing date and such notice shall offer the Stockholders the opportunity to register such number of Registrable Securities as each Stockholder may request. Upon the written request of any such
Stockholder given to the Company within twenty (20) days after receipt of such notice delivered by the Company, the Company shall, subject to the provisions of Section 2(d), use its best efforts to cause to be
registered under the Securities Act all of the Registrable Securities that each such Stockholder has requested to be registered. 

  
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 (c) Registration on Form S-3. If at any time
after the Effective Time (i) any Stockholder or Stockholders request that the Company file a registration statement on Form S-3 or any successor thereto for a public offering of all or any portion of the
Registrable Securities held by such requesting holder or holders, the reasonably anticipated aggregate price to the public of which would exceed $3,000,000, and (ii) the Company is a registrant entitled to use Form S-3 or any successor thereto to register such Registrable Securities, then the Company shall use its best efforts to, as soon as practicable, register under the Securities Act on Form
S-3 or any successor thereto, for public sale in accordance with the method of disposition specified in such notice, the number of Registrable Securities specified in such notice. The number of registrations
on Form S-3 which may be requested and obtained under this Section 2(c) shall be limited to no more than two (2) per calendar year. 

(d) Underwriting Requirements. In connection with any underwritten offering pursuant to Section 2(a), if the
managing underwriter shall advise the Company that, in its view, the number or proposed mix of securities requested to be included in such registration (including securities which the Company desires to be included which are not Registrable
Securities) exceeds the largest number of securities which can be sold without having a material adverse effect on such offering (the “Maximum Offering Size”), including the price at which such securities can be sold, the Company
will include in such registration: 
 (i) first, shares of Common Stock issued or issuable upon conversion of the
shares of Preferred Stock requested by the Stockholders to be included in such registration pursuant to Section 2(a), with the shares so included to be apportioned pro rata among the Stockholders according to the
total number of such shares of Common Stock owned by each such Stockholder (including any shares of Common Stock issued or issuable upon conversion of the Preferred Stock) or in such other proportions as shall be agreed upon by such Stockholders, if
the total number of shares requested to be included in such registration by the Stockholders exceeds the Maximum Offering Size; 

(ii) second, any Registrable Securities other than the ones referenced in (i) above requested by the Stockholders
to be included in such registration pursuant to Section 2(a), with the shares so included to be apportioned pro rata among the Stockholders according to the total number of Registrable Securities owned by each such
Stockholder (excluding any shares of Preferred Stock or shares of Common Stock issued or issuable upon conversion of the Preferred Stock, but assuming the conversion into Common Stock of all outstanding Convertible Securities other than such
Preferred Stock) or in such other proportions as shall be agreed upon by such Stockholders, to the extent such total amount of Registrable Securities requested to be included in such registration by the Stockholders exceeds the Maximum Offering
Size; and 

  
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 (iii) third, after registration of the total amount of Registrable
Securities requested to be included in such registration by the Stockholders, any securities to be sold for the account of other Persons (including the Company) which shall not cause the Maximum Offering Size to be exceeded, with such priorities
among the Company and such other Persons as the Company shall determine. 
 In connection with any underwritten offering pursuant to
Section 2(b), if the managing underwriter shall advise the Company that, in its view, the number or mix of securities (including all Registrable Securities) which the Company, the Stockholders and any other Persons intend
to include in such registration exceeds the Maximum Offering Size, the Company will include in such registration, in the priority listed below, securities up to the Maximum Offering Size: 

(iv) first, securities to be sold for the Company’s own account; 

(v) second, Registrable Securities requested to be included in such registration by Stockholders pursuant to
Section 2(b) with the shares so included to be apportioned pro rata among the Stockholders according to the total amount of Registrable Securities owned by each such Stockholder calculated on a fully diluted basis
(i.e., assuming the conversion into Common Stock of all outstanding Convertible Securities) or in such other proportions as shall be agreed upon by such Stockholders (if necessary); and 

(vi) third, shares of Common Stock requested to be included in such registration by all other Persons, allocated (if
necessary) pro rata among such Persons on the basis of the relative number of securities each such Person has requested to be included in such registration, or as such Persons may otherwise agree. 

(e) Expenses of Registration. The Company shall bear and pay all expenses incurred in connection with any registration, filing or
qualification of shares with respect to registrations pursuant to this Section 2, including, without limitation, all registration, filing, qualification, Blue Sky, printing and accounting fees relating or apportionable
thereto, but excluding underwriting discounts and commissions relating to shares being registered, applicable transfer taxes and expenses of counsel to the Stockholders, which shall be borne by the Stockholders selling shares being registered.
Notwithstanding anything in this paragraph to the contrary, upon demand of the Stockholders, the Company shall pay the reasonable expenses of one separate counsel for the Stockholders to be selected by the Stockholders holding a majority of the
Registrable Securities held by Stockholders and included in such registration, filing or qualification. 
 (f) Company Delay or
Withdrawal of Registration. At the time of any request to register Registrable Securities pursuant to Section 2(a), if the Board of Directors of the Company determines in its good faith reasonable judgment that the
Company should not file any registration statement otherwise required to be filed pursuant to such Section 2(a) because the Company is engaged in or plans to engage in any financing, acquisition or other material
transaction which would be adversely affected by the filing of such a registration statement, the Company shall be entitled to postpone for the shortest reasonable period of time (but not exceeding ninety (90) days from the date of the
request), the filing of such registration statement and shall promptly give the Stockholders who have requested the filing of such registration statement under Section 2(a) and any other Stockholders who have requested the

  
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registration of their Registrable Securities under Section 2(a) written notice of such determination, containing a general statement of the reasons for such postponement
and an approximation of the anticipated delay. If the Company shall so postpone the filing of the registration statement, the Stockholders who made the request for registration under Section 2(a) shall have the right to
withdraw the request for registration by giving written notice to the Company within thirty (30) days after receipt of the notice of postponement. Such right to delay a request for registration pursuant to this
Section 2(f) may not be exercised more than once in any twelve (12) month period. Without limiting the foregoing, the Company shall have no liability to any Stockholder for the Company’s withdrawal of any
registration as to which a Stockholder has registration rights under Section 2(b) (except reimbursement of expenses incurred prior to such withdrawal in accordance with paragraph (e) above); provided, that such
withdrawal is made by the Company in good faith and not for the purpose of impairing any Stockholder’s rights under such Section 2(b). 

(g) Rule 144 Reporting. With a view to making available the benefits of certain rules and regulations of the SEC which may at any time
permit the sale of the Registrable Securities by the Stockholders to the public without registration, at all times after ninety (90) days after any registration statement covering a public offering of securities of the Company under the
Securities Act shall have become effective, the Company agrees to: 
 (i) make and keep public information available, as
those terms are understood and defined in Rule 144 under the Securities Act; 
 (ii) use its best efforts to file with the
SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act; and 

(iii) furnish to each Stockholder holding Registrable Securities forthwith upon request a written statement by the Company as
to its compliance with the reporting requirements of such Rule 144 and of the Securities Act and the Exchange Act, a copy of the most recent annual or quarterly report of the Company, and such other reports and documents so filed by the Company as
such Stockholder may reasonably request in availing itself of any rule or regulation of the SEC allowing such Stockholder to sell any Registrable Securities without registration. 

(h) Obligations of the Company. Whenever required under this Section 2 to effect the registration of any
Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (i) prepare and file with the SEC a
registration statement with respect to such shares and use its best efforts to cause such registration statement to become and remain effective until the disposition of all securities covered by the registration statement; 

(ii) prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in
connection therewith as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement; 

  
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 (iii) furnish to the Stockholders such number of copies of a prospectus,
including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of the shares owned by them and covered by a registration
statement filed under this Section 2;  
 (iv) use its best efforts to register and qualify
the securities covered by such registration statement under such other securities or Blue Sky laws of such states or jurisdictions as shall be reasonably requested by the Stockholders; provided, that the Company shall not be required in
connection therewith or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions; 

(v) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement,
in usual and customary form, with the managing underwriter(s) of such offering (and each Stockholder participating in such underwriting shall also enter into and perform its obligations under such an underwriting agreement); 

(vi) notify each Stockholder holding shares covered by such registration statement as promptly as possible at any time when a
prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material
fact or omits to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading and promptly prepare (and file with the SEC) and furnish to
such Stockholders a reasonable number of copies of a supplement to or an amendment of such prospectus as may be necessary so that, as thereafter delivered to the purchasers of such Securities, such prospectus shall not include an untrue statement of
a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing; 

(vii) furnish, at the request of any Stockholder requesting registration of shares pursuant to this
Section 2, on the date that such shares are delivered to the underwriters for sale in connection with a registration pursuant to this Section 2 (if such shares are being sold through underwriters)
or, if such shares are not being sold through underwriters, on the date that the registration statement with respect to such shares becomes effective, (i) an opinion, dated as of such date, of counsel representing the Company for the purposes
of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Stockholders participating in such registration of shares, and (ii) a
“comfort” letter, dated as of such date, from the independent certified public accountants of the Company, in form and substance as in customarily given by independent certified public accountants to underwriters in an underwritten public
offering, addressed to the underwriters, if any, and to the Stockholders requesting registration of shares; 

  
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 (viii) notify Stockholders whose shares are included in the registration
statement promptly of any request by the SEC for the amendment or supplement of such registration statement or prospectus or for additional information, and notify such Stockholders promptly of the filing of each amendment or supplement to such
registration statement or prospectus; 
 (ix) advise Stockholders whose shares are included in the registration statement,
promptly after it shall receive notice, of the issuance of any stop order by the SEC suspending the effectiveness of such registration statement or the initiation or threatening of any proceeding for that purpose and promptly use its best efforts to
prevent the issuance of any stop order or to obtain its withdrawal if such stop order should be issued; 
 (x) furnish to
each Stockholder whose shares are included in the registration statement at least one conformed copy of the registration statement and any amendments thereto; 

(xi) provide each Stockholder whose shares are included in the registration statement and its representatives a reasonable
opportunity, after entering into a confidentiality agreement which is reasonably satisfactory to the Company, to conduct an inquiry of the Company’s financial and other records during normal business hours and make available during normal
business hours and without unreasonable disruption to the Company’s business or operations, its officers, directors and employees to provide such information as such Stockholder may reasonably request to fulfill any due diligence obligations
that such Stockholder may have; 
 (xii) keep the registration statement effective for a period ending on the earlier of the
date that is ninety (90) days from the effective date of the registration statement or such time as the Stockholders have completed the distribution described in the registration statement; 

(xiii) cause all Registrable Securities registered on the registration statement to be listed each national securities exchange
on which similar securities issued by the Company are then listed; and 
 (xiv) provide a transfer agent and registrar for
all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

(i) Obligations of Stockholders. In connection with any registration required to be effected pursuant to this
Section 2, the Stockholders selling any shares in connection with such registration shall furnish to the Company such information regarding themselves, the shares held by them and the intended method of disposition of such
shares as shall be required or reasonably necessary to effect the registration of their shares. 

  
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 (j) Lock-Up Agreement. Each Stockholder
hereby agrees that in connection with any registration of securities of the Company relating to an underwritten offering thereof to the general public, to the extent requested by the Company or the underwriter of such offering, such Stockholder (to
the extent such Stockholder then holds, individually or together with its Affiliates, two percent (2%) or more of the outstanding shares of Common Stock, or is an officer, director or employee of the Company) shall not, whether or not such
Stockholder is participating in such registration, sell, contract to sell, grant any option or right to purchase, lend, pledge, enter into any swap or other arrangement that transfers economic consequences of ownership or otherwise transfer or
dispose of (other than in a private sale or to donees who agree to be similarly bound) any shares of Common Stock or any other securities convertible into Common Stock (other than those shares, if any, which are in fact included in such
registration) without the prior written consent of the Company or the applicable underwriters, as the case may be, for such period (the “Lock-Up Period”) of time (not to exceed (x) one
hundred eighty (180) days with respect to the initial public offering of the Common Stock, or (y) ninety (90) days with respect to any other offering) from the effective date of the registration statement for such registration as the
Company or such underwriters may specify in writing. Each Stockholder hereby further agrees that (to the extent such Stockholder then holds, individually or together with its Affiliates, two percent (2%) or more of the outstanding shares of Common
Stock, or is an officer, director or employee of the Company), if reasonably requested by any underwriter or underwriters in any such offering, such Stockholder shall enter into a lock-up agreement in the form
(containing customary terms) reasonably requested by such underwriter or underwriters for such offering, provided, that such lock-up agreement does not provide (i) for a longer lock-up period than the Lock-Up Period contained in this Section 2(j) or (ii) terms that are more onerous to such Stockholder than those
applicable to any similarly situated Stockholder. Each Stockholder further agrees that the underwriters of any such offering are intended to be third-party beneficiaries of this Section 2(j) and such beneficiaries shall be
entitled to enforce the provisions of this Section 2(j) an their own behalf as though they were a party hereto. The provisions of this Section 2(j) shall not be deemed to prevent the Stockholders
from exercising their rights under Section 2(b) hereof in connection with any such underwritten offering. 
 (k)
Indemnification. The Company will, and hereby does, indemnify and hold harmless, in the case of any registration statement filed pursuant to this Section 2, each seller of any Registrable Securities covered by such
registration statement, its directors and officers, each other person who participates as an underwriter in the offering or sale of such securities, each officer and director of each such underwriter, and each such other person, if any, who controls
such seller or any such underwriter within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act, (collectively, the “Seller Indemnitees”), against any losses, claims, damages, liabilities and
expenses, joint or several, to which such Seller Indemnitee may become subject under the Securities Act or otherwise, insofar as such losses, claims, damages, liabilities or expenses (or actions or proceedings in respect thereof) arise out of or are
based upon (i) any untrue statement or alleged untrue statement of any material fact contained in any registration statement under which such securities were registered under the Securities Act, any preliminary prospectus, final prospectus or
summary prospectus included therein, or any amendment or supplement thereto, or any document incorporated by reference therein; (ii) any omission or alleged omission to state therein a material fact required to be stated therein or necessary to
make the statements therein not misleading; and (iii) any violation by the Company of any applicable securities laws in connection with such registration statement, preliminary prospectus, final prospectus or summary prospectus, or any related
“free 

  
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writing prospectus”, or amendment or supplement thereto or document incorporated by reference therein; and the Company will reimburse such Seller Indemnitee for any legal or any other
expenses reasonably incurred by them in connection with investigating or defending such loss, claim, liability, action or proceeding; provided, however, that the Company shall not be liable to any Seller Indemnitee in any such case to
the extent that any such loss, claim, damage, liability (or action or proceeding in respect thereof) or expense arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission made in such registration
statement, any such preliminary prospectus, final prospectus, summary prospectus, amendment or supplement, or any document incorporated by reference therein, in reliance upon and in conformity with written information furnished to the Company for
use in the preparation thereof by such Seller Indemnitee. Such indemnity shall remain in full force and effect regardless of any investigation made by or on behalf of any Seller Indemnitee and shall survive the transfer of such securities by such
seller. 
 The Company may require, as a condition to including any Registrable Securities in any registration statement pursuant to this
Section 2, that the Company shall have received an undertaking satisfactory to it from each prospective seller of such securities, to, severally and not jointly, indemnify and hold harmless (in the same manner and to the
same extent as set forth in the preceding paragraph, except that no such prospective seller shall in any event be liable pursuant thereto for any amount in excess of the net proceeds of sale received by such seller from the sale by it of Registrable
Securities under such registration statement) the Company, each officer and director of each such underwriter and each other person, if any, who controls the Company or the underwriter, and each other seller, with respect to any statement in or
omission from such registration statement, any preliminary prospectus, final prospectus or summary prospectus included therein, or any amendment or supplement thereto, or any related “free-writing prospectus”, or any document incorporated
by reference therein, but only if such statement or omission was made in reliance upon and in conformity with written information furnished by such indemnifying prospective seller to the Company for use in the preparation of or inclusion in such
registration statement, preliminary prospectus, final prospectus, summary prospectus, amendment or supplement, or document incorporated by reference therein. Such indemnity shall remain in full force and effect regardless of any investigation made
by or on behalf of the Company or any such director, officer, controlling person or other seller and shall survive the transfer of such securities by such seller. The indemnity contemplated by this paragraph shall not apply to amounts paid in
settlement of any losses, claims, damages, liabilities or expenses (or actions in respect thereof) if such settlement is effected without the consent of the Stockholder from whom indemnification is sought (which consent shall not be unreasonably
withheld or delayed). 
 Promptly after receipt by an indemnified party of notice of the commencement of any action or proceeding (including
a governmental investigation) involving a claim referred to in this Section 2(k), such indemnified party will, if a claim in respect thereof is to be made against an indemnifying party under this
Section 2(k), give written notice to the latter of the commencement of such action; provided, however, that the failure of any indemnified party to give notice as provided herein shall not relieve the
indemnifying party of its obligations under the preceding provisions of this Section 2(k), except to the extent that the indemnifying party is actually prejudiced by such failure to give notice. In case any such action is
brought against an indemnified party, unless in such indemnified party’s reasonable judgment a conflict of interest between such indemnified and indemnifying parties 

  
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may exist in respect of such claim (in which case, the indemnifying party shall be liable for the fees and expenses of one counsel for the underwriters and other sellers in connection with any
one action or separate but similar or related actions), the indemnifying party will be entitled to participate in and to assume the defense thereof, jointly with any other indemnifying party similarly notified, to the extent that it may wish, with
counsel reasonably satisfactory to such indemnified party, and after notice from the indemnifying party to such indemnified party of its election so to assume the defense thereon, the indemnifying party will not be liable to such indemnified party
for any legal or other expenses subsequently incurred by the latter in connection with the defense thereof (except as expressly set forth above). 

(l) Rights of Stockholders. No person shall be granted registration rights which conflict with or which are more favorable to such
Stockholder than the registration rights set forth in this Agreement. At the election of the Company and the holders of greater than fifty percent (50%) of the total number of then issued and outstanding shares of Preferred Stock held by all
Stockholders (including for purposes of this calculation any issued and outstanding shares of Common Stock issued upon conversion of shares of Preferred Stock), which Stockholders shall include Mitsui and Kirin, respectively, so long as Mitsui or
Kirin, as applicable, owns at least fifty percent (50%) of the number of shares of Preferred Stock (including for purposes of this calculation any issued and outstanding shares of Common Stock issued upon conversion of shares of Preferred Stock)
owned by them, respectively, as of the Effective Time (subject to proportionate adjustment in the case of any stock split, reverse stock split, recapitalization, reclassification stock dividend or other distribution with respect to such shares), new
stockholders of the Company may be given the opportunity to receive the registration rights provided under this Agreement by being permitted to execute an Instrument of Accession to this Agreement in the form of Exhibit A attached hereto
(and, upon execution, be added to Schedule 1) or be given registration rights on another basis less favorable to such new stockholder. 

3. SEVERABILITY. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid
under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any
other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such invalid, illegal or unenforceable provision had never been contained herein. 

4. ENTIRE AGREEMENT. Except as otherwise expressly set forth herein, from and after the Effective Time and unless and until thereafter
amended, this document will embody the complete agreement and understanding among the parties hereto with respect to the subject matter hereof and will supersede and preempt any prior understandings, agreements or representations by or among the
parties, written or oral, with respect to such subject matter. 
 5. SUCCESSORS AND ASSIGNS. This Agreement will bind and inure to
the benefit of and be enforceable by the Company and the Stockholders and their respective successors and permitted assigns. 

  
 -12- 

 6. COUNTERPARTS; EFFECTIVENESS OF AGREEMENT. This Agreement may be executed by
original, facsimile, PDF or other electronic signature (including Docusign) and in separate counterparts each of which will be an original and all of which taken together will constitute one and the same agreement. This Agreement shall become
effective as of the Effective Time but automatically shall terminate and be deemed null and void ab initio if the SPRA is terminated or the Closing (as defined in the SPRA) otherwise does not occur for any reason. 

7. REMEDIES. The Stockholders will be entitled to enforce their rights under this Agreement specifically (without posting a bond or
other security), to recover damages by reason of any breach of any provision of this Agreement and to exercise all other rights existing in their favor. The parties hereto acknowledge and agree that in the event of any breach of this Agreement by
the Company, the Stockholders would be irreparably harmed and could not be made whole by monetary damages. Each party hereto accordingly agrees (a) not to assert by way of defense or otherwise that a remedy at law would be adequate, and
(b) that the parties agree, in addition to any other remedy to which they may be entitled, that the remedy of specific performance of this Agreement is appropriate in any action in court. In the event of any dispute involving the terms of this
Agreement, the prevailing party shall be entitled to collect reasonable fees and expenses incurred by the prevailing party in connection with such dispute from the non-prevailing parties to such dispute. 

8. RECAPITALIZATION, ETC. In the event that any capital stock or other securities are issued in respect of, in exchange for, or in
substitution of, any shares of Common Stock by reason of any reorganization, recapitalization, reclassification, merger, consolidation, spin-off, partial or complete liquidation, stock dividend, split-up, sale of assets, distribution to Stockholders or combination of the Common Stock or any other change in capital structure of the Company, appropriate adjustments shall be made with respect to the relevant
provisions of this Agreement so as to fairly and equitably preserve, as far as practicable, the original rights and obligations of the parties hereto under this Agreement. 

9. AMENDMENT AND WAIVER. No modification, amendment or waiver of any provision of this Agreement will be effective against the Company
or the Stockholders unless such modification, amendment or waiver is approved in writing by the Company and the holders of greater than fifty percent (50%) of the total number of then issued and outstanding shares of Preferred Stock held by all
Stockholders, which holders shall include Mitsui and Kirin, respectively, so long as Mitsui or Kirin, as applicable, owns at least fifty percent (50%) of the number of shares of Preferred Stock (including for purposes of this calculation any issued
and outstanding shares of Common Stock issued upon conversion of shares of Preferred Stock) owned by them, respectively, as of the Effective Time (subject to proportionate adjustment in the case of any stock split, reverse stock split,
recapitalization, reclassification stock dividend or other distribution with respect to such shares); provided, however that no such modification, amendment or waiver shall be effective against any Stockholder who has not consented to
such modification, amendment or waiver to the extent that such modification, amendment or waiver would be adverse to the interests of such Stockholder in any material respect and would have a disproportionate impact in any material respect on the
rights of such Stockholder in its capacity as a Stockholder hereunder when measured against the impact of such modification, amendment or waiver on the rights of other Stockholders in their capacities as Stockholders hereunder.

  
 -13- 

 
The Company shall notify all Stockholders of each modification, amendment or waiver of any provision of this Agreement that could reasonably be expected to affect the rights of such Stockholder
hereunder at least five (5) business days prior to the effectiveness of such modification, amendment or waiver. The failure of any party to enforce any of the provisions of this Agreement will in no way be construed as a waiver of such
provisions and will not affect the right of such party thereafter to enforce each and every provision of this Agreement in accordance with its terms. 

10. TERMINATION. This Agreement (and the right of any Stockholder to request registration or inclusion of Registrable Securities in any
registration) will terminate with respect to each applicable Stockholder upon the earliest to occur of: 
 (a) any Liquidation Event (as
defined in the Company’s Fifth Amended and Restated Certificate of Incorporation as in effect as of the Effective Time or as amended or modified from time to time); 

(b) such time after consummation of an initial public offering of the Common Stock under the Securities Act as Rule 144 or another similar
exemption under the Securities Act is available for the sale of all of such Stockholder’s shares without limitation during a three-month period without registration; or 

(c) a termination of this Agreement pursuant to Section 6 hereof; 

provided, that the provisions of Section 2(e) and Section 2(k) shall survive any termination
pursuant to Section 10(a) or Section 10(b) above. 
 11. GOVERNING LAW; JURY TRIAL
WAIVER. ALL QUESTIONS CONCERNING THE CONSTRUCTION, VALIDITY AND INTERPRETATION OF THIS AGREEMENT WILL BE GOVERNED BY THE LAWS OF THE STATE OF DELAWARE, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. THE PARTIES HERETO AGREE TO WAIVE
ANY RIGHT TO HAVE ANY DISPUTE ARISING HEREUNDER OR OTHERWISE IN CONNECTION WITH THE TRANSACTIONS CONTEMPLATED HEREBY ADJUDICATED BY A JURY, AND HEREBY AGREE TO SUBMIT TO THE COURTS OF THE STATE OF DELAWARE IN CONNECTION WITH THE RESOLUTION OF ANY
SUCH DISPUTE. 
 12. DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement are inserted for convenience only and do
not constitute a part of this Agreement. 
 13. CONSTRUCTION. The language used in this Agreement will be deemed to be the language
chosen by the parties to express their mutual intent, and no rule of strict construction will be applied against any party. 

  
 -14- 

 14. NOTICES. All notices, demands, and other communications hereunder shall be in
writing or by written telecommunication, and shall be deemed to be duly given if delivered personally or by overnight courier or if mailed by certified mail, return receipt requested, postage prepaid, or sent by telecopier, as follows: 

If to the Company, to: 

Thorne Holding Corp. 

152 West 57th Street 

New York, NY 10019 

Attn: Paul Jacobson 

(917) 859-2505 

Email: pjacobson@thorne.com 

With copies (which shall not constitute notice) sent contemporaneously to: 

Womble Bond Dickinson (US) LLP 

One West Fourth Street 

Winston-Salem, NC 27101 

Attn: Christopher J. Gyves 

(336) 721-3634 

Email: christopher.gyves@wbd-us.com 

If to the Stockholders, to the addresses set forth on Schedules 1 and 2 attached hereto. 

If to any Additional Stockholder, to the address for such Additional Stockholder on Schedule 1 attached hereto (or such other address
as such Additional Stockholder shall specify by written notice given pursuant to this Agreement). 
 [Balance of Page Intentionally Left
Blank] 

  
 -15- 

 IN WITNESS WHEREOF, the parties hereto have executed this Registration Rights Agreement on
the day and year first above written. 
  

			
	COMPANY:
	
	THORNE HOLDING COMPANY
		
	By:	 	/s/ Paul Jacobson
	Name: Paul Jacobson
	Title: Chief Executive Officer

  
 -1- 

  

			
	INITIAL STOCKHOLDER:
	
	DIVERSIFIED NATURAL PRODUCTS, INC.
		
	By:	 	/s/ Paul Jacobson
	Name: Paul Jacobson
	Title: Authorized Signatory

  
 -1- 

 
			
	INITIAL STOCKHOLDER:
	
	IDB HOLDING S.P.A
		
	By:	 	/s/ Daniele Giovini
	Name: Daniele Giovini
	Title:   General Manager

  
 -1- 

 
			
	INITIAL STOCKHOLDER:
	
	MONASHEE CAPITAL MASTER FUND LP
		
	By:	 	/s/ Tom Wynn
	Name: Tom Wynn
	Title:   Partner

  
 -1-EX-4.2

 Exhibit 4.2 

FOURTH AMENDED AND RESTATED STOCKHOLDER AGREEMENT 

This FOURTH AMENDED AND RESTATED STOCKHOLDER AGREEMENT (this “Agreement”), dated as of July 5, 2018 and effective as of
the Effective Time, is entered into by and among (i) Thorne Holding Corp., a Delaware corporation (the “Company”), (ii) the Stockholders listed on Schedule 1 hereto (the “Initial Stockholders”), (iii)
the entities listed on Schedule 2 hereto (the “Purchasers”) and (iv) each Person who shall, subsequent to the date hereof, join in and become a party to this Agreement by executing an Instrument of Accession
(“Instrument of Accession”) in the form of Exhibit A hereto (collectively, the “Subsequent Stockholders”). Capitalized terms used herein without definition shall have the meanings assigned to such terms in
Section 1 hereof. 
 WHEREAS, the Company and WestView Capital Partners II, L.P. (“WestView”),
Tudor Ventures III L.P. (“Tudor”), Diversified Natural Products, Inc. (“DNP”), Albert Czap (“Czap”), ELUS Holdings Corporation, IdB Holding S.p.A, the James L. Gilbert Trust — 1994
(“Gilbert”), Monashee Capital Master Fund L.P. and Mitsui & Co., Ltd. are parties to that certain Third Amended and Restated Stockholder Agreement, dated as of November 22, 2017, among the Company and the parties
referred to therein (the “Amended Agreement”); 
 WHEREAS, the Company, the Purchasers, WestView, Tudor, Czap, Gilbert,
ELUS Holdings Corporation and DNP have entered into a Preferred Stock Purchase and Securities Redemption Agreement (the “SPRA”), dated as of the date hereof, pursuant to which, among other things, (a) the Purchasers will
purchase shares of the Company’s Series E Preferred Stock, $0.01 par value per share (the “Series E Preferred Stock”), (b) Mitsui will exchange its outstanding shares of the Company’s Series D Preferred Stock, $0.01 par
value per share, for newly issued shares of Series E Preferred Stock, (c) the Company will redeem all outstanding capital stock of the Company held by WestView, Tudor, Czap and Gilbert, (d) ELUS Holdings Corporation will exchange its
outstanding shares of the Company’s Series B Preferred Stock, $0.01 par value per share, for newly issued shares of Common Stock, and (e) immediately after the consummation of the transactions described in the foregoing clauses (b), (c)
and (d), all remaining shares of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock shall be converted into shares of Common Stock; 

WHEREAS, in connection with the Closing under the SPRA, the undersigned Stockholders and the Company, being all of the parties necessary to
amend the Amended Agreement in accordance with the terms thereof, have agreed to amend and restate the Amended Agreement in its entirety in the form of this Agreement; 

WHEREAS, also simultaneous with and conditioned upon the execution of this Agreement, the Company and Purchasers shall enter into a Fourth
Amended and Restated Registration Rights Agreement (the “Registration Rights Agreement”), pursuant to which, among other things, the parties thereto shall agree to certain rights and obligations relating to the registration of
capital stock of the Company for public sale and certain other matters relating thereto; 
 WHEREAS, but for the execution and delivery of
this Agreement by the Company and the Initial Stockholders, the Company and the Purchasers would not be willing to enter into the SPRA or consummate the transactions contemplated thereby, which transaction will benefit the parties; and 

 WHEREAS, the parties hereto wish to set forth certain rights and obligations of the parties
with regard to, among other things, (a) the transfer and issuance of Securities, (b) the election of Persons to the Board of Directors of the Company (the “Board of Directors”) and committees thereof, (c) the manner
in which Securities will be voted with respect to certain matters, and (d) certain other matters concerning the parties’ ownership and transfer of Securities, and the management and affairs of the Company. 

NOW, THEREFORE, the parties to this Agreement hereby agree to amend and restate the Amended Agreement in its entirety, as set forth herein,
and further agree as follows: 
 1. DEFINITIONS. For all purposes of this Agreement, the following terms shall have the meanings set
forth below: 
 “5% Holder” shall mean any Stockholder that, together with its Affiliates, holds outstanding Common Stock
or Preferred Stock representing at least five percent (5%) of the outstanding Securities (determined on a fully-diluted and an as-converted to Common Stock basis but not giving effect to the exercise of any
outstanding options or warrants to purchase Common Stock). 
 “Adjustment Notification” shall have the meaning set forth in
Section 2.6(b) hereof. 
 “Affiliate” means, with respect to any Person, any other Person that directly, or indirectly
through one or more intermediaries, controls, is controlled by, or is under common control with, such first Person. 

“Agreement” shall have the meaning set forth in the preamble hereof. 

“Amended Agreement” shall have the meaning set forth in the recitals hereof. “Approved Sale” shall have the meaning
set forth in Section 3.1(a) hereof. “Audit Committee” shall have the meaning set forth in Section 4.1(c) hereof. “Board of Directors” shall have the meaning set forth in the recitals hereof. “Budget” shall
have the meaning set forth in Section 7.1(d) hereof. 
 “Business Day” means a day other than a Saturday, Sunday or
other day on which commercial banks in the City of New York are authorized or required to close. 
 “Charter” shall mean
the Company’s Fifth Amended and Restated Certificate of Incorporation, as filed with the Secretary of State of Delaware at or about the Effective Time, as amended and in effect from time to time. 

“Common Directors” shall have the meaning set forth in Section 4.1(a)(iv) hereof. 

“Common Stock” shall mean the Company’s common stock, $0.01 par value per share. 

“Company” shall have the meaning set forth in the preamble hereof. 

“Company Legal Matters” shall have the meaning set forth in Section 24 hereof. 

  
 -2- 

 “Company Sale” means any of the following (in each case by means of any
transaction or series of related transactions): (i) any Person or group of related Persons acquires Securities representing (A) the voting power to elect a majority of the directors of the Board of Directors, or (B) a majority of the fully
diluted Common Stock; (ii) the Company consolidates or combines with or merges into another Person, or any Person consolidates or combines with or merges into the Company, and (B) the holders of the capital stock of the Company immediately
prior to such transaction do not own, directly or indirectly, at least a majority of the capital stock of the surviving company immediately after the consummation of the transaction; (iii) the sale of all or substantially all of the assets of
the Company and its Subsidiaries taken as a whole; or (iv) a transaction that qualifies as a “Deemed Liquidation Event” as defined in the Charter. The Purchasers and their Affiliates shall not be deemed to constitute a group of
related Persons for purposes of the Company Sale definition. 
 “Compensation Committee” shall have the meaning set forth
in Section 4.1(c) hereof. “Confidential Information” shall have the meaning set forth in Section 8 hereof. “Czap” shall have the meaning set forth in the recitals hereof. 

“Designated Holders” shall mean each of Mitsui and Kirin, respectively, so long as such respective Stockholder and its
Affiliates at the applicable date and time continue to hold Securities representing at least fifty percent (50%) of the number of Total Shares owned by such Stockholder at the Effective Time (after giving effect to any subsequent stock splits,
combinations or similar transactions involving one or more classes of applicable Securities as a class). 
 “DNP” shall
have the meaning set forth in the recitals hereof. 
 “Downward Valuation Adjustment” shall have the meaning set forth in
Section 2.6(a) hereof. 
 “Effective Time” shall mean the Closing, as defined in the SPRA. 

“ELUS” shall mean ELUS Holdings Corporation, Helsinn Healthcare, S.A. and their Affiliates. 

“Exempt Transfers” shall have the meaning set forth in Section 2.1(a)(ii) hereof. “Exercisable Security” shall
have the meaning set forth in Section 3.2(vi) hereof. “Exercising Holders” shall have the meaning set forth in Section 5.1(c) hereof. 

“Family Members” shall mean, with respect to any individual, any Related Person or Family Trust of such individual. 

“Family Trust” shall mean, with respect to any individual, any trust or limited liability company created solely for the
benefit of one or more of such individual’s Related Persons and controlled by such individual. 
 “First Election
Period” shall have the meaning set forth in Section 2.2 hereof. 
 “GAAP” shall have the meaning set forth in
Section 7.1(b) hereof. 
 “Gilbert” shall have the meaning set forth in the recitals hereof. 

  
 -3- 

 “Independent Third Party” shall mean, with respect to any Stockholder, any
individual or entity who is not an Affiliate of such Stockholder. 
 “Initial Public Offering” shall mean the first
underwritten public offering of Common Stock by the Company registered under the Securities Act (other than a registration statement relating either to the sale of securities to employees of the Company pursuant to its stock option, stock purchase
or similar plan or an SEC Rule 145 transaction). 
 “Initial Stockholders” shall have the meaning set forth in the preamble
hereof. “Instrument of Accession” shall have the meaning set forth in the preamble hereof. “Investor Offer Notice” shall have the meaning set forth in Section 2.2(a) hereof. “IPO Notification” shall have the
meaning set forth in Section 2.6(b) hereof. “Issuance Notice” shall have the meaning set forth in Section 5.1(b) hereof. “Issuance Security” shall have the meaning set forth in Section 5.1(a) hereof.
“Jacobson” shall have the meaning set forth in Section 4.1(a)(iv) hereof. 
 “Japan Person” shall mean
(x) any Person that has been incorporated, organized or formed under the laws of Japan, (y) any Person that is a national or citizen of Japan, or (z) any Person that is a direct or indirect subsidiary of a Person meeting the
requirements set forth in clause (x) or (y). 
 “Kirin” means Kirin Holdings Company, Limited, a Japanese corporation.

 “Majority Stockholders” shall mean, from time to time, Stockholders then holding a majority of outstanding shares of
Common Stock and Preferred Stock (voting together on an as-converted to Common Stock basis). 

“McKenna” shall have the meaning set forth in Section 4.1(a)(iv) hereof. “Mitsui” means Mitsui & Co.,
Ltd., a Japanese corporation. 
 “Non-Designated Holders” means Stockholders other
than the Designated Stockholders. 
 “Non-K/M Directors” means the members of the
Board of Directors other than members designated by Mitsui under Section 4.1(a)(i) and members designated by Kirin under Section 4.1(a)(ii). 

“Offer” shall have the meaning set forth in Section 2.7(a) hereof. 

“Offer Notification” shall have the meaning set forth in Section 2.7(b) hereof. 

“Participating Stockholders” shall have the meaning set forth in Section 2.3 hereof. 

“Person” shall mean an individual, partnership, limited liability company, corporation, association, trust, joint venture,
unincorporated organization, or any government, governmental department or agency or political subdivision thereof. 
 “Personal
Representative” shall mean the successor or legal representative (including, without limitation, a guardian, executor, administrator or conservator) of a dead or incompetent Stockholder. 

  
 -4- 

 “Preferred Stock” shall mean the Series E Preferred Stock. 

“Pre-Emptive Right Notice Period” shall have the meaning set forth in
Section 5.1(b) hereof. 
 “Purchasers” shall have the meaning set forth in the preamble hereof. “Purchase
Right” shall have the meaning set forth in Section 5.1(a) hereof. 
 “Related Persons” shall mean, with
respect to any individual, such individual’s parents, siblings, spouse, children and grandchildren. 
 “Registration Rights
Agreement” shall have the meaning set forth in the recitals hereof. 
 “Second Election Period” shall have the
meaning set forth in Section 2.2(d) hereof. “Secondary Purchase Right” shall have the meaning set forth in Section 5.1(c) hereof. 

“Securities” shall mean (i) any capital stock of the Company, including but not limited to any shares of Common Stock
and any shares of Preferred Stock, and (ii) any warrants, options or other rights or securities exchangeable or exercisable for or convertible into capital stock of the Company. 

“Securities Act” shall mean the United States of America Securities Act of 1933, as amended, and the rules and regulation
promulgated thereunder. 
 “Series A Preferred Stock” shall mean the Company’s Series A Preferred Stock, $0.01 par
value per share. 
 “Series B Preferred Stock” shall mean the Company’s Series B Preferred Stock, $0.01 par value per
share. 
 “Series C Preferred Stock” shall mean the Company’s Series C Preferred Stock, $0.01 par value per share.

 “Series D Preferred Stock” shall mean the Company’s Series D Preferred Stock, $0.01 par value per share. 

“Series E Preferred Stock” shall have the meaning set forth in the recitals hereof. “SPRA” shall have the meaning
set forth in the recitals hereof. 
 “Stockholders” shall mean, collectively, the Initial Stockholders, the Purchasers and
any Subsequent Stockholders. 
 “Subsequent Stockholders” shall have the meaning set forth in the preamble hereof. 

“Subsidiary” shall mean, with respect to the Company, without duplication, any corporation, limited liability company,
partnership, association, other business entity, or joint venture or joint venture arrangement, of which (a) if a corporation, at least fifty percent (50%) of the total voting power of the capital stock entitled to vote (without regard to the
occurrence of any contingency) in the election of directors, managers, or trustees thereof is at the time in question owned or controlled, 

  
 -5- 

 
directly or indirectly, by the Company or one or more of the other Subsidiaries of the Company or a combination thereof, or (b) if a limited liability company, partnership, association,
other business entity (other than a corporation), or joint venture or joint venture arrangement, at least fifty percent (50%) of the membership, partnership or other ownership interests or units thereof are at the time owned or controlled, directly
or indirectly, by the Company or one or more Subsidiaries of the Company or a combination thereof, and for this purpose, a specified Person or Persons shall be deemed to own a majority ownership interest in such a business entity (other than a
corporation) if the Company or its direct or indirect Subsidiaries are allocated a majority of such business entity’s gains or losses, or control any managing member, managing director or general partner of such business entity (other than a
corporation). For clarity, (x) each of the following entities is a Subsidiary as of the date hereof: Thorne Research, Inc., an Idaho corporation, Health Elements, LLC, a Delaware limited liability company, WellnessFX, Inc., a Delaware
corporation, HEU Holding Company, a Florida corporation, Drawbridge Health, Inc., a Delaware corporation, and YouCare Joint Venture LTD; and (y) none of the following entities is a Subsidiary as of the date hereof: Pillar Health, LLC, a
Delaware limited liability company (“Pillar”), and Thorne OPS-FUEL Joint, LLC (otherwise known as Tecton, LLC), a Delaware limited liability company (“Tecton”). 

“Third Election Period” shall have the meaning set forth in Section 2.2(e) hereof. 

“Total Shares” means at any time of determination the total of (i) all shares of Common Stock outstanding at such time
plus (ii) all shares of Common Stock issuable upon the conversion of all shares of Preferred Stock outstanding at such time. 

“Transfer” shall have the meaning set forth in Section 2.1(a) hereof. 

“Transferring Stockholder” shall have the meaning set forth in Section 2.2(a) hereof. 

“Tudor” shall have the meaning set forth in the recitals hereof. 

“WBD” shall have the meaning set forth in Section 24 hereof. 

“WestView” shall have the meaning set forth in the recitals hereof. 

2. RESTRICTIONS ON TRANSFER OF SECURITIES. 

2.1 Transfer. 
 (a)
Notwithstanding anything to the contrary in this Agreement, no Stockholder may sell, assign, pledge or otherwise transfer, directly or indirectly, voluntarily or involuntarily, by operation of law or otherwise (a “Transfer”), any
rights or interest in any Securities, without strict compliance with the terms of Sections 2.2, 2.3 and 2.5; provided, however, that the provisions of Sections 2.2 and 2.3 shall not apply: 

(i) Subject to Section 2.1(b), in the case of any Stockholder that is not a natural person, to a
Transfer of Securities to its Affiliates, general or limited partners, stockholders, members or other equity holders, 

  
 -6- 

 (ii) Subject to Section 2.1(b), in the case of any
Stockholder that is a natural person, to a Transfer of Securities to such Stockholder’s Personal Representative or Family Members; provided, that, in the case of a Transfer to a Related Person, such Stockholder retains voting and dispositive
control of the Securities until such Stockholder’s death or incapacity, 
 (iii) Subject to
Section 2.1(b), in the case of a Designated Holder or an Affiliate thereof, to a Transfer of Securities to the other Designated Holder or an Affiliate thereof, and 

(iv) in the case of any Stockholder, pursuant to an Approved Sale (subsections (i) through (iv) inclusive, collectively
the “Exempt Transfers”). 
 (b) The restrictions contained in this Section 2 will continue to be
applicable to the transferred Securities after any Exempt Transfer under Section 2.1(a)(i), Section 2.1(a)(ii) or Section 2.1(a)(iii), and, as a condition precedent to any
such Exempt Transfer, the transferee of the transferred Securities to the extent not already a party to this Agreement shall have executed and delivered to the Company an Instrument of Accession. 

2.2 First Right of Purchase. 

(a) Any Stockholder (the “Transferring Stockholder”) proposing to make any Transfer of Securities, other than an Exempt
Transfer (a “Proposed Transfer”), shall deliver a written notice (the “Investor Offer Notice”) to the Designated Holders and the Company at least forty-five (45) days prior to the Proposed Transfer. The
Investor Offer Notice will state the Transferring Stockholder’s bona fide intention to make the Proposed Transfer, and disclose in reasonable detail the material terms of the Proposed Transfer, including the number of Securities proposed to be
Transferred, the class or classes of such Securities, the proposed price and the identity of the proposed transferee, and the status of the Transferring Stockholder’s arrangement with the proposed transferee (including whether the proposed
transferee has made a binding offer or is otherwise committed to acquire the Securities to be transferred). 
 (b) Subject to the terms of
this Section 2.2, the Designated Holders may elect to purchase all or any portion of the Securities specified in the Investor Offer Notice at the price and on the terms specified therein by delivering written notice of such
election to the Transferring Stockholder, the other Stockholders and the Company within forty-five (45) days after the Designated Holders’ receipt of the Investor Offer Notice (“First Election Period”). The Designated
Holders may, in their discretion, allocate between them the Securities (if any) to be purchased in such election, such allocation to be set forth in the written notice of such election. In the absence of such mutual allocation, the Designated
Holders shall be entitled to purchase their respective pro rata shares of the Securities specified in the Investor Offer Notice, based on the number of Total Shares held by each Designated Holder and its Affiliates divided by the number of Total
Shares then held by both Designated Holders and their Affiliates. 
 (c) If the Designated Holders elect to purchase Securities being
offered, the consummation of such purchase will take place by the later of (i) thirty (30) days after the expiration of the First Election Period, and (ii) five (5) Business Days after receipt of all consents, waivers and approvals
necessary to consummate such purchase. 

  
 -7- 

 (d) If the Designated Holders do not elect to purchase all of the Securities specified in
the Investor Offer Notice, the Company may elect to purchase the balance of the Securities specified in the Investor Offer Notice at the price and on the terms specified therein by delivering written notice thereof to the Transferring Stockholder
and the other Stockholders within fifteen (15) days after the expiration of the First Election Period (the “Second Election Period”). If the Company elects to purchase Securities being offered, the consummation of such purchase
will take place by the later of (i) thirty (30) days after the expiration of the Second Election Period, and (ii) five (5) Business Days after receipt of all consents, waivers and approvals necessary to consummate such purchase. 

(e) If the Company does not elect to purchase all of the Securities specified in the Investor Offer Notice, the Company shall provide written
notice to the 5% Holders (other than the Designated Holders), including a copy of the Investor Offer Notice, within two (2) Business Days after the date that the Second Election Period expires, setting forth the amount of the Securities that
the Designated Holders and the Company did not elect to purchase, and each of the 5% Holders (other than the Designated Holders) may elect to purchase some or all of the balance of the Securities specified in the Investor Offer Notice at the price
and on the terms specified therein by delivering written notice thereof to the Transferring Stockholder, the other Stockholders and the Company within fifteen (15) days after the date of delivery of such notice from the Company (the
“Third Election Period”). 
 (f) If any 5% Holder elects to purchase any of the remaining Securities pursuant to
Section 2.2(e), the consummation of such purchase will take place by the later of (i) thirty (30) days after the expiration of the Third Election Period, and (ii) three (3) days after receipt of all consents,
waivers and approvals necessary to consummate such purchase. If more than one such 5% Holder elects to purchase any of the Securities being offered, each such 5% Holder electing to purchase such Securities will be entitled to purchase from the
Transferring Stockholder a pro rata portion based upon the respective numbers of Securities (determined on a fully diluted and an as-converted to Common Stock basis but not giving effect to the exercise of any
outstanding options or warrants to purchase Common Stock) then held by such electing 5% Holders, with the consummation of such purchase to take place by the later of (i) thirty (30) days after the expiration of the Third Election Period, and
(ii) five (5) Business Days after receipt of all consents, waivers and approvals necessary to consummate such purchase. 
 (g) If the
Designated Holders, the Company and/or the 5% Holders do not elect to purchase all of the Securities specified in the Investor Offer Notice, neither the Designated Holders, the Company nor the 5% Holders shall be entitled to purchase any of the
Securities specified in the Investor Offer Notice, and the Transferring Stockholder may, within ninety (90) days but not less than ten (10) days after the expiration of the Third Election Period, but subject to
Section 2.3, complete the Proposed Transfer at a price and on terms no more favorable to the transferees than the price and terms offered in the Investor Offer Notice; provided that no such Proposed Transfer may be
completed unless each of such transferees shall have executed and delivered an Instrument of Accession to the Company as a condition precedent thereto. If the Transferring Stockholder fails to consummate such Proposed Transfer within the ninety
(90) day period after the expiration of the Third Election Period, any subsequent proposed Transfer of such Securities shall be once again subject to the provisions of this Section 2.2. 

  
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 2.3 Co-Sale Rights. In the event of a
proposed Transfer of Securities by a Designated Holder (other than an Exempt Transfer) with respect to which the Company and the 5% Holders are entitled to but do not elect to purchase all of the Securities proposed to be transferred, each of the 5%
Holders (other than the Transferring Stockholder, any 5% Holder that elected to purchase Securities specified in the Investor Offer Notice under Section 2.2 or any 5% Holder who is an employee of the Company or any of its
Subsidiaries) may elect to participate in the contemplated sale by delivering written notice to the transferring Designated Holder within fifteen (15) days after expiration of the Third Election Period. If any of such 5% Holders elects to
participate in such sale (the “Participating Stockholders”), each of such transferring Designated Stockholder and the Participating Stockholders will be entitled to sell in the contemplated sale, on the same terms as are applicable
to the Designated Holder, that number of Securities determined by multiplying (i) (x) the aggregate number of Securities covered by the Investor Offer Notice, minus (y) the number of Securities purchased pursuant to
Section 2.2, by (ii) a fraction, the numerator of which is the number of Securities owned by such Stockholder on the date of receipt of the Investor Offer Notice by such Stockholder (determined on a fully-diluted and
an as-converted to Common Stock basis but not giving effect to the exercise of any outstanding options or warrants to purchase Common Stock) and the denominator of which is the total number of Securities owned
by the Designated Stockholder and all Participating Stockholders on such date (determined on a fully-diluted and an as-converted to Common Stock basis but not giving effect to the exercise of any outstanding
options or warrants to purchase Common Stock). The Designated Holder will use its commercially reasonable efforts to obtain the agreement of the prospective transferee(s) to the participation of the Participating Stockholders in any contemplated
sale; provided that if the prospective transferee(s) declines to allow the participation of the Participating Stockholders on the terms specified herein, the proposed Transfer may be consummated if the Designated Holder, within five
(5) days after such consummation, purchases the Securities that the Participating Stockholders would have sold in such proposed Transfer had the prospective transferee(s) not declined to allow their participation; provided,
further, if the prospective transferee(s) objects to the delivery of convertible Preferred Stock in lieu of Common Stock, the Stockholder holding the relevant convertible Preferred Stock shall first convert the Preferred Stock into Common
Stock and deliver Common Stock (and the Company agrees to make any such conversion concurrent with and contingent upon the consummation of the contemplated sale). 

2.4 Transfers of Securities in Breach of this Agreement. In the event of any Transfer or attempted Transfer of Securities in breach of
this Agreement, commencing immediately upon the date of such attempted Transfer (a) such Transfer shall be void and of no effect, (b) no dividend of any kind or any distribution pursuant to any liquidation, redemption or otherwise shall be
paid by the Company to the purported transferee in respect of such Securities, with the amount of any such dividend or distribution being retained by the Company until such time as such Transfer has been finally rescinded and reversed, and
(c) neither the putative transferring Stockholder nor the purported transferee shall be entitled to exercise any rights with respect to such Securities under this Agreement until such Transfer in breach of this Agreement has been rescinded.

 2.5 Transfer to Competitors. Prior to the fourth anniversary of the Effective Time, and provided that Mitsui is a Designated
Holder at the time of such purported Transfer, no Stockholder may Transfer any Securities to any Japan Person unless the Stockholder proposing such Transfer first obtains the written consent of Mitsui. Prior to the fourth anniversary of the
Effective Time, and provided that Kirin is a Designated Holder at the time of such purported Transfer, no Stockholder may Transfer any Securities to any Japan Person unless the Stockholder proposing such Transfer first obtains the written consent of
Kirin. 

  
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 2.6 Initial Public Offering. 

(a) If, at any time following the fourth anniversary of the Effective Time, the Non-K/M Directors, in
good faith and consistent with their fiduciary duties, unanimously resolve to pursue or commence registration for an Initial Public Offering for which the Board of Directors have received advice from a nationally recognized investment banking firm
selected by the Non-K/M Directors and reasonably acceptable to the Board of Directors that such Initial Public Offering is reasonably likely to be consummated within fifteen (15) months following such
resolution of the Non-K/M Directors and to result in an offering price per share that would imply a net equity valuation of the Company of at least $400,000,000, then the members of the Board of Directors
designated by Kirin and Mitsui shall not object to the pursuit or commencement of such Initial Public Offering and the Designated Holders shall not unreasonably withhold any stockholder consent required to pursue or consummate such Initial Public
Offering; provided, however, that, notwithstanding the foregoing, the foregoing commitment of the members of the Board of Directors designated by Kirin and Mitsui shall cease to apply and the Designated Holders shall have the right to
withhold any consent with respect to such Initial Public Offering or revoke any consent previously granted if at any time before such Initial Public Offering has occurred, the managing underwriter indicates that such Initial Public Offering is not
likely to result in an offering price per share that would imply a net equity valuation of the Company of at least $400,000,000 (such decrease in valuation, a “Downward Valuation Adjustment”). So long as no Downward Valuation
Adjustment has occurred, the Designated Holders (i) shall not interfere with any steps reasonably undertaken by the Company with respect to such Initial Public Offering; (ii) shall, as may be necessary to facilitate the approval,
authorization or recommendation of any such Initial Public Offering, replace any members of the Board of Directors designated by Kirin and Mitsui who do not vote in favor of, authorize or recommend a proposal to pursue or commence such Initial
Public Offering; and (iii) shall vote their shares in favor of the consummation of the transactions necessary to complete such Initial Public Offering and otherwise consent to and raise no objection to the consummation of such transactions;
provided that, notwithstanding the foregoing, neither Designated Holder nor any Affiliate thereof shall be required to terminate or otherwise amend or modify any commercial or other agreements that such Designated Holder or such Affiliate has
entered into with the Company or any of its Affiliates, except to the extent necessary to remove prohibitions on, or to permit the authorization of, the consummation of such Initial Public Offering (it being understood and agreed that nothing herein
will require the Designated Holders to terminate, amend or modify any rights granted pursuant to Section 2.6(b)). The Company shall keep the Designated Holders reasonably informed with respect to such Initial Public
Offering (including, without limitation, the status, timing, pricing and other terms thereof) and shall deliver to the Designated Holders copies of all material documents (including drafts thereof and comments thereto) and correspondence to or from
the managing underwriter and the SEC related to such Initial Public Offering (with such delivery to be at substantially the same time as when such documents and correspondence are distributed or received by the Company), including without limitation
the prospectus, registration statement and drafts and mark-ups of definitive agreements. 
 (b) The
Company (i) shall promptly notify (the “IPO Notification”) the Designated Holders in writing if the conditions triggering an Initial Public Offering described in Section 2.6(a) have been

  
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satisfied and (ii) shall promptly notify (the “Adjustment Notification”) the Designated Holders if any Downward Valuation Adjustment has occurred. The IPO Notification shall
describe in reasonable detail the material terms of such Initial Public Offering, including the proposed Initial Public Offering valuation (which shall have been reasonably determined by the Board of Directors following consultation with a
nationally recognized investment banking firm), the name and address of the proposed managing underwriter, the expected offering date, and the proposed national securities exchange for such Initial Public Offering, and shall include a copy of all
documents exchanged with the proposed managing underwriter. The Adjustment Notification shall describe in reasonable detail the reason for the Downward Valuation Adjustment and the revised terms and pricing of such Initial Public Offering. Following
the delivery of any IPO Notification, the Designated Holders shall have one hundred twenty (120) days to elect and commit in writing to purchase all Securities not held by the Designated Holders at the proposed Initial Public Offering
valuation. If the Designated Holders elect and commit in writing to purchase all such Securities, then each Stockholder shall be required to sell its Securities to the Designated Holders, and the Designated Holders shall be required to purchase such
Securities, at a per Security purchase price (which, for the avoidance of doubt, shall be reduced by the exercise price payable with respect to any option, warrant or similar Security) based on the proposed Initial Public Offering valuation (in case
of a Downward Valuation Adjustment, such valuation shall be reduced as reflected in the Adjustment Notification) and pursuant to purchase and sale documents in customary form reasonably acceptable to the Designated Holders and at a closing date
reasonably agreed by the Board of Directors and the Designated Holders. If the consummation of the Initial Public Offering provided for in the IPO Notification does not occur for any reason, the rights and obligations set forth in this
Section 2.6(b) shall continue, including the obligation of the Company to provide the IPO Notification and the right of the Designated Holders to purchase all Securities not held by the Designated Holders at the proposed
Initial Public Offering valuation. Following the delivery of any Adjustment Notification, the Designated Holders shall have ten (10) Business Days to revoke any prior stockholder consent to the extent such revocation is permitted pursuant to
Section 2.6(a). 
 2.7 Acquisition of the Company. 

(a) If, at any time following the fourth anniversary of the Effective Time, the Company receives a definitive offer from a reputable third
party for a Company Sale which the Non-K/M Directors, consistent with their fiduciary duties, unanimously resolve to pursue (an “Offer”), the members of the Board of Directors designated by
Kirin and Mitsui shall not object to such Offer and the Designated Holders shall not withhold any stockholder consent required to consummate such Offer, provided that such Offer: (i) will result in Kirin and Mitsui receiving all cash as
consideration for their Securities, (ii) is fully financed and subject only to limited, reasonable and customary conditions, (iii) values the Company at a net equity value of not less than $400,000,000, (iv) is not subject to any
contingent or conditional consideration (including, without limitation, holdbacks, escrows, installment payments, milestones or earn-out provisions) that could result in less than $400,000,000 being delivered
to the aggregate holders of Securities at the consummation of such Offer and (v) otherwise complies with the conditions for an Approved Sale set forth in the last sentence and related subparagraphs of Section 3.1. The
Designated Holders (i) shall not interfere with any steps reasonably undertaken by the Company with respect to such Offer and (ii) shall, as may be necessary to facilitate the approval, authorization or recommendation of any such Offer,
replace any members of the Board of Directors designated by Kirin and Mitsui who do not vote in favor of, authorize or 

  
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recommend the Offer. The Designated Holders shall vote their shares in favor of the consummation of the transactions necessary to complete such Offer and otherwise consent to and raise no
objection to the consummation of such transactions, and shall take all actions to waive any appraisal or similar dissenters rights that they may have in connection with the consummation of such transactions; provided that, notwithstanding the
foregoing, neither Designated Holder nor any Affiliate thereof shall be required to terminate or otherwise amend or modify any commercial or other agreements that such Designated Holder or such Affiliate has entered into with the Company or any of
its Affiliates. The Company shall keep the Designated Holders reasonably informed of such transactions (including, without limitation, the status, timing, economic and other terms thereof) and shall deliver to the Designated Holders copies of all
material documents (including drafts thereof and comments thereto) distributed to or received from the proposed acquirer (at substantially the same time as when distributed to or received from the proposed acquirer) in connection with such Offer,
including without limitation confidentiality agreements, acquisition proposals, letters of intent, indications of interest, term sheets, drafts and mark-ups of definitive agreements and documents related to
financing. 
 (b) The Company will promptly notify (the “Offer Notification”) the Designated Holders in writing if the
conditions triggering an Offer described in Section 2.7(a) have been satisfied. The Offer Notification shall describe in reasonable detail the material terms and conditions of such Offer, including the name and address of
the proposed acquirer, its source of financing and the expected date, time and location of the proposed consummation of such Offer, and shall include a copy of any term sheet, letter of intent, indication of interest or acquisition proposal. Within
forty-five (45) days following the delivery of the Offer Notification, the Designated Holders shall have the right to commit in writing to purchase all Securities not held by the Designated Holders at the valuation specified in the Offer. If
the Designated Holders elect and commit in writing to purchase all such Securities, then each Stockholder shall be required to sell its Securities to the Designated Holders, and the Designated Holders shall be required to purchase such Securities,
at a per Security purchase price (which, for the avoidance of doubt, shall be reduced by the exercise price payable with respect to any option, warrant or similar Security) based on the valuation specified in the Offer and pursuant to purchase and
sale documents in customary form reasonably acceptable to the Designated Holders and at a closing date reasonably agreed by the Non-K/M Directors and the Designated Holders. If the consummation of the Offer
provided for in the Offer Notification does not occur for any reason, the rights and obligations set forth in this Section 2.7(b) shall continue, including the obligation of the Company to provide the Offer Notification and the right of the
Designated Holders to purchase all Securities not held by the Designated Holders at the valuation specified in the Offer. 
 3. SALE OF
THE COMPANY. 
 3.1 Approved Sale. In the event a Company Sale is approved by the Board of Directors and the Majority
Stockholders (an “Approved Sale”), such Majority Stockholders may, at their joint election, require each other Stockholder to participate in such Approved Sale in a manner set forth in Section 3.2. Any such
election shall be made by written notice to the Company, and upon receipt of such election notice the Company shall be required to promptly deliver notice of such exercise to all other Stockholders no less than twenty (20) days prior to the
consummation of such Approved Sale. Such notice to the other Stockholders shall describe in reasonable detail the material terms and conditions of such Approved Sale, including the name and address of the proposed acquirer and the

  
 -12- 

 
expected date, time and location of the proposed closing, and shall include a copy of the term sheet or letter of intent, if any. Any Approved Sale shall be subject to the following conditions:

 (i) each such Stockholder shall receive, with respect to such Stockholder’s Securities, consideration that is no less
than every other Stockholder receives with respect to his, her or its Securities of the same type, class and series (provided, that differences in net proceeds attributable to differing exercise or conversion prices with respect to Securities
of the same type, class or series shall not be deemed to constitute differing consideration); 
 (ii) any rights and
liquidation preferences provided by the Charter shall be honored and all amounts payable pursuant to any Approved Sale shall be otherwise paid in accordance with the Charter (including pursuant to the last paragraph of
Section 2.1 of the Charter); 
 (iii) if any Stockholder is given an option as to the form and
amount of consideration to be received as a result of the Approved Sale with respect to any class and series of Securities, each other Stockholder shall have been given the same option with respect to such class and series of Securities; 

(iv) no Stockholder, other than any Stockholder who may be an officer or employee of the Company or its Affiliates, shall be
required to agree to any non-competition, non-solicitation or similar restriction or to provide any release other than a release of claims relating directly to such
Stockholder’s authority, ownership and the ability to convey title to their respective Securities; 
 (v) no Stockholder
shall be obligated to undertake any indemnity that is joint in nature or could exceed (I) in the case of any indemnity relating to a breach of representations and warranties relating to the Company (and not such Stockholder), such
Stockholder’s pro rata share of such indemnification obligation calculated based on such Stockholder’s pro rata share of the aggregate net proceeds received by all Stockholders in connection with such Approved Sale, or (II) in any
case, the amount of the proceeds received by such Stockholder in the Approved Sale; and 
 (vi) any representations and
warranties to be made by each Stockholder in connection with the Approved Sale shall be limited to representations and warranties as to such Stockholder only (and not the Company) related to authority, ownership and the ability to convey title to
their respective Securities, including but not limited to representations and warranties that (i) the Stockholder holds all right, title and interest in and to the Securities such Stockholder purports to hold, free and clear of all liens and
encumbrances, (ii) the obligations of the Stockholder in connection with the transaction have been duly authorized by or on behalf of the Stockholder, if applicable, (iii) the documents to be entered into by the Stockholder have been duly
executed by such Stockholder and delivered to the acquirer and are enforceable against such Stockholder in accordance with their respective terms, subject to equitable exceptions, and (iv) neither the execution and delivery of documents to be
entered into in connection with the transaction, nor the performance of such Stockholder’s obligations thereunder, will cause a breach or violation of the terms of any agreement, law or judgment, or order or decree of any court or governmental
agency, to which it is bound which would impair such Stockholder’s ability to consummate the Approved Sale. 

  
 -13- 

 3.2 Obligations of Stockholders with respect to an Approved Sale. Subject to
Section 3.1, the Company and the Stockholders shall use their reasonable best efforts to cause the consummation of any Approved Sale and shall not take any action prejudicial to or inconsistent with, or that would otherwise
materially delay, any Approved Sale. Without limiting the generality of the foregoing, each Stockholder shall: 
 (i) vote
such Stockholder’s Securities in favor of, or to otherwise approve, the terms of any Approved Sale and such matters ancillary thereto as are customary; 

(ii) waive and disclaim any appraisal, dissenters or similar rights that such Stockholder may have in connection with an
Approved Sale; 
 (iii) sell all of such Stockholder’s Securities on the terms and conditions approved by the Board of
Directors (but only if the consideration for such Approved Sale is paid entirely in cash or publicly tradeable securities (or securities immediately convertible into publicly tradeable securities solely at the holder’s option)); 

(iv) enter into any agreement or agreements required to be entered into by such Stockholder to effectuate the Approved Sale and
enter into such other customary agreements, documents, certificates and instruments as are applicable to the Approved Sale and otherwise are consistent with the requirements and limitations in Section 3.1 and this
Section 3.2; 
 (v) upon request, deliver such Stockholder’s Securities (together with
executed instruments of transfer or assignment) in escrow (pending receipt of the purchase price therefor) to counsel for the Company or the Majority Stockholders in such sale; 

(vi) subject to the terms of any Exercisable Security (as defined below), upon the election of the Company in its sole
discretion and without any further action required on the part of such Stockholder, each stock option, warrant, and other similar right then exercisable for shares of capital stock of the Company (collectively, “Exercisable
Securities” and individually, an “Exercisable Security”), shall, if such Stockholder has not otherwise exercised the vested portion of such Exercisable Security prior to the closing of an Approved Sale (or any such
Exercisable Security contains a vesting acceleration provision that becomes effective immediately prior to the closing of an Approved Sale), be cancelled in connection with an Approved Sale in exchange for an amount of cash or such other
consideration payable in connection with such Approved Sale with an aggregate value equal to (A) the consideration payable in respect of each share of the class or series of capital stock underlying such Exercisable Security in connection with
such Approved Sale, multiplied by the number of shares of such class or series of capital stock underlying such Exercisable Security that remain unexercised as of the closing of such Approved Sale, minus (B) the exercise
price per share for such Exercisable Security multiplied by the number of shares of such class or series of capital stock underlying such Exercisable Security that remain unexercised as of the closing of such Approved Sale; provided, that if
the result of such calculation is a positive number, any 

  
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such payment shall be subject to the terms and conditions generally applicable to the payment of the consideration in connection with such Approved Sale, including indemnification obligations,
escrows, earnouts, contingency payments, purchase price adjustments, and payment in accordance with the terms of the Charter; and 

(vii) if the consideration to be paid in exchange for the Securities pursuant to this Section 3.2
includes any securities and due receipt thereof by any Stockholder would require under applicable law (x) the registration or qualification of such securities or of any Person as a broker or dealer or agent with respect to such securities or
(y) the provision to any Stockholder of any information other than such information as a prudent issuer would generally furnish in an offering made solely to “accredited investors” as defined in Regulation D promulgated under the
Securities Act of 1933, as amended, the Company may cause to be paid to any such Stockholder in lieu thereof, against surrender of the Securities which would have otherwise been sold by such Stockholder, an amount in cash equal to the fair value (as
determined in good faith by the Company’s Board of Directors) of the securities which such Stockholder would otherwise receive as of the date of the issuance of such securities in exchange for the Securities. 

3.3 PROXY. WITHOUT LIMITING SECTION 4.3 BELOW, EACH STOCKHOLDER HEREBY
APPOINTS A DESIGNEE OF THE DESIGNATED HOLDERS IN ANY APPROVED SALE AS SUCH STOCKHOLDER’S TRUE AND LAWFUL PROXY AND ATTORNEY, WITH FULL POWER OF SUBSTITUTION, TO VOTE AT ANY MEETING OF THE STOCKHOLDERS OF THE COMPANY, HOWEVER CALLED, OR ANY
ADJOURNMENT THEREOF, OR BY WRITTEN CONSENT OF THE STOCKHOLDERS OF THE COMPANY, ALL VOTING SECURITIES OWNED BY SUCH STOCKHOLDER OR OVER WHICH SUCH STOCKHOLDER HAS VOTING CONTROL TO EFFECTUATE THE AGREEMENTS AND OBLIGATIONS OF SUCH STOCKHOLDER SET
FORTH IN THIS SECTION 3 IN THE EVENT OF ANY BREACH BY SUCH STOCKHOLDER OF ITS OBLIGATIONS UNDER THIS SECTION 3. THE PROXIES AND POWERS
GRANTED BY EACH STOCKHOLDER PURSUANT TO THIS SECTION 3.3 ARE COUPLED WITH AN INTEREST AND ARE GIVEN TO SECURE THE PERFORMANCE OF SUCH STOCKHOLDER’S DUTIES UNDER THIS
SECTION 3. SUCH PROXIES ARE IRREVOCABLE FOR SO LONG AS THIS SECTION 3 REMAINS IN EFFECT AND WILL SURVIVE THE DEATH, INCOMPETENCE OR
DISABILITY OF ANY STOCKHOLDER WHO IS AN INDIVIDUAL AND THE MERGER, LIQUIDATION OR DISSOLUTION OF ANY STOCKHOLDER THAT IS A CORPORATION, PARTNERSHIP OR OTHER ENTITY. 

4. BOARD OF DIRECTORS; VOTING AGREEMENTS. 

4.1 Board of Directors. 

(a) The Board of Directors shall consist of seven (7) directors. Subject to Section 4.1(b), in any and all
elections of directors of the Company (whether at a meeting or by written consent in lieu of a meeting), each Stockholder shall vote, or cause to be voted, or cause such Stockholder’s 

  
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designees as directors to vote, all voting Securities owned by such Stockholder or over which such Stockholder has voting control so as to nominate and elect as directors: 

(i) So long as Mitsui is a Designated Holder, two (2) individuals designated by Mitsui, who shall initially be Masami
Yokoyama and Toshitaka Inuzuka; 
 (ii) So long as Kirin is a Designated Holder, two (2) individuals designated by
Kirin, who shall initially be Tom Yoshimura and Shinro Fujita; 
 (iii) So long as ELUS and its Affiliates collectively hold
at least 10% of the Total Shares, one (1) individual designated by ELUS, who shall initially be Riccardo Braglia; and 

(iv) Two (2) individuals elected by the vote of the majority of the outstanding shares of Common Stock and Preferred Stock
(voting together as a single class on an as-converted to Common Stock basis) (the “Common Directors”), one of whom will be Paul Jacobson (“Jacobson”) so long as Jacobson is
employed as the Chief Executive Officer of the Company and Thorne Research, Inc. and the second of whom will be elected from the following group of executives of the Company and Thorne Research, Inc.: (v) Chief Financial Officer, (w) President,
(x) Chief Operating Officer, (y) Chief Marketing Officer and (z) Chief Technology Officer; provided, that the second Common Director shall not be an Affiliate of a Designated Holder and shall be independent (applying the standards
of Section 303A.02(a)(i)-(ii) of the NYSE Listed Company Manual) of the Designated Holders; provided, further, that an individual shall not be disqualified from serving as a director solely as a result of the individual’s
status as an employee of the Company. It is agreed that Tom McKenna (“McKenna”) will be the initial Common Director other than Jacobson. 

The Designated Holders shall consult with the Chief Executive Officer of the Company on a non-binding basis, and shall
consider the Chief Executive Officer’s recommendations and views in good faith, with respect to the designation of the Common Director and the directors to be designated pursuant to Section 4.1(a)(i) or (ii).

 (b) If any vacancy shall occur on the Board of Directors as a result of death, disability, resignation, removal or any other termination
of a director, the replacement for such vacating director shall be designated by the Person or Persons who, pursuant to Section 4.1(a) above, originally designated such vacating director, or in the case of the Common
Directors, by the vote of the majority of the outstanding shares of Common Stock and Preferred Stock (voting together as a single class on an as-converted to Common Stock basis). Each Person or group of
Persons (as applicable) entitled to designate a director or a replacement for a director pursuant to this Section 4 shall also be entitled to remove such director from the Board of Directors and any applicable committees
thereof with or without cause and to designate the replacement for any director so removed. Each Stockholder shall vote, or cause to be voted, or cause such Stockholder’s designees as directors to vote, all voting Securities owned by such
Stockholder or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to comply with this Section 4.1(b). In the event that Mitsui, Kirin or ELUS loses
the right to designate members of the Board of Directors pursuant to Sections 4.1(a)(i), (ii) or (iii), as applicable, then such member(s) of the Board of Directors shall be designated by the vote of the majority of the
outstanding shares of Common Stock and Preferred Stock (voting together as a single class on an as-converted to Common Stock basis). 

  
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 (c) There will be a compensation committee of the Board of Directors, consisting of no more
than five (5) directors (the “Compensation Committee”), and an audit committee of the Board of Directors, consisting of no more than five (5) directors (the “Audit Committee”). The Designated Holders
acting jointly shall have the right to appoint from among their respective Board of Director appointees a majority of the members of any committee of the Board of Directors, with each Designated Holder entitled to appoint an equal number of members
to any such committee (including the Compensation Committee and the Audit Committee), and the members of any Board of Directors committee not so appointed by the Designated Holders shall be appointed by the Board of Directors from among its members.
The Chief Executive Officer of the Company shall serve as a member on the Compensation Committee. The Chief Executive Officer of the Company will be recused from all Compensation Committee discussions concerning such Chief Executive Officer or with
respect to which such Chief Executive Officer reasonably could be deemed to have a conflict of interest. The Compensation Committee shall be charged with approving salaries, incentive or similar compensation and grants of options, restricted stock
awards and other equity based compensation for key employees of the Company. The Audit Committee shall be charged with assisting the Board of Directors in fulfilling its oversight responsibilities to its stockholders by reviewing the financial
reports and other financial information provided by the Company to its stockholders, to any governmental body or to the public; the Company’s systems of internal control; and the Company’s auditing, accounting and financial reporting
processes generally. There will not be any other committee (including without limitation any executive committee) of the Board of Directors unless such committee is specifically approved by (x) the Board of Directors and (y) the majority
of the outstanding shares of Common Stock and Preferred Stock (voting together as a single class on an as-converted to Common Stock basis). In the event an executive committee, or similar committee, including
any committee delegated the responsibilities of the full Board of Directors or responsibilities typically held by an executive committee or similar committee is formed pursuant to the provisions of this Section 4.1(c), then
the composition of such committee shall be determined in accordance with the second sentence of this Section 4.1(c). 

(d) Action of the Board of Directors shall be by approval of a majority of all directors then in office, including at least one
(1) director appointed by each Designated Holder. Action by any committee of the Board of Directors shall be by approval of a majority of all members of the committee then in office, including at least one (1) member appointed by each
Designated Holder. The approval of the Board of Directors shall be required for all matters for which approval of the Board of Directors is required by law or that are material to the Company. 

(e) The rights of a Designated Holder under this Section 4.1 shall be assignable in whole or in part to any Person
(including, for clarity, the other Designated Holder or their respective Affiliates) if such Person acquires more than fifty percent (50%) of the number of shares of Preferred Stock held by the Designated Holder at the Effective Time or any shares
issued upon a conversion of such shares of Preferred Stock into Common Stock (after giving effect to any stock splits, combinations or similar transactions involving one or more classes of Securities as a whole) and provided the Transfer of such
shares to such Person would not violate Section 2.5. The rights of ELUS under this Section 4.1 shall be assignable in whole or in part to any Person (including, for clarity, any Designated Holder
or their respective Affiliates) who acquires all of the shares of Common Stock and other securities of the Company held by ELUS and provided the Transfer of such shares to such Person would not violate Section 2.5. 

  
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 (f) The Company shall reimburse the members of the Board of Directors for the reasonable out-of-pocket expenses incurred by in attending meetings of the Board of Directors. The Company also shall at all times maintain directors and officers insurance coverage from
a carrier and in an amount and scope of coverage as is satisfactory to the Board, including at least one (1) director appointed by each Designated Holder, for the benefit of the current and former members of the Board of Directors and any
committee thereof (both as to the Company and as to any subsidiary, Affiliate or other entity with respect to which any such person is serving as a director, manager or equivalent capacity at the request or for the benefit of the Company). 

(g) The Company shall cause meetings of the Board of Directors to be held no less frequently than four (4) times in each twelve
(12) calendar month period. 
 (h) Notwithstanding anything to the contrary contained in the Company’s Bylaws, the Company shall
give notice of any regular or special meeting of the Board of Directors or any applicable committee thereof to each director then serving on the Board of Directors or such committee, and each observer designated hereunder. Such notices shall state
the place, if any, date, and hour of the meeting, and the means of remote communication, if any, by which directors may be deemed to be present in person and vote at such meeting. In the case of a special meeting, the notice shall state the purpose
or purposes for which the meeting is called and no business other than that specified in the notice shall be transacted at a special meeting. Notices may be given by personal delivery, mail, telegram, courier service (including, without limitation,
Federal Express), facsimile transmission (directed to the facsimile transmission number at which the director has consented to receive notice), electronic mail (directed to the electronic mail address at which the director has consented to receive
notice), or other form of electronic transmission pursuant to which the director has consented to receive notice. If notice is given by personal delivery, by facsimile transmission, by telegram, by electronic mail, or by other form of electronic
transmission pursuant to which the director has consented to receive notice, then such notice shall be given on (i) not less than seventy-two (72) hours’ notice to each director prior to the
meeting, in the case of a regular meeting, and (ii) not less than forty-eight (48) hours’ notice to each director prior to the meeting, in the case of a special meeting. If written notice is delivered by mail or courier service, then
it shall be given on not less than five (5) Business Days’ notice to each director prior to the meeting. For the avoidance of doubt, any director may waive the requirements for notice contained herein on behalf of him or herself and the
party designating such director. 
 (i) No party, nor any Affiliate of any such party, shall have any liability as a result of designating a
person for election as a director for any act or omission by such designated person in his or her capacity as a director of the Company, nor shall any party have any liability as a result of voting for any such designee in accordance with the
provisions of this Agreement. 
 (j) The Company shall use its commercially reasonable efforts to obtain, within sixty (60) days of the
Effective Time, from financially sound and reputable insurers, Directors and Officers Errors and Omissions insurance, which shall cover the directors and officers of the Company and its 

  
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Subsidiaries, each in an amount satisfactory to the Board of Directors, and the Company will use commercially reasonable efforts to cause such insurance policies to be maintained until such time
as the Board of Directors determines that such insurance should be discontinued. Without limiting the foregoing, such policies shall not be cancelable by the Company or any such Subsidiary without prior approval of the Board of Directors. 

4.2 Vote to Increase Authorized Common Stock. Each Stockholder shall vote, or cause to be voted, all voting Securities owned by such
Stockholder or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to increase the number of authorized shares of Common Stock to ensure that there will be sufficient shares of
Common Stock available for conversion of all of the shares of Preferred Stock (and any Securities from time to time held by the Designated Holders) outstanding at any given time. 

4.3 Secondment. Each Designated Holder shall have the right to second one or more employees of the Designated Holder or an Affiliate
thereof to serve as secondees to the Company or any of its Subsidiaries, with the rights and on the terms set forth in a secondment agreement between such Designated Holder, the Company and the applicable secondee in a form to be reasonably agreed
by such parties (which shall include reasonable and customary provisions with respect to confidentiality, conflicts of interest and assignment of intellectual property rights no less restrictive than the corresponding provisions of agreements
executed by employees of the Company). 
 4.4 PROXY. WITHOUT LIMITING SECTION 3.3 ABOVE, EACH
STOCKHOLDER HEREBY GRANTS TO THE DESIGNATED HOLDERS, AND IF THERE ARE NO SUCH DESIGNATED HOLDERS, TO THE PRESIDENT OF THE COMPANY, AN IRREVOCABLE PROXY, COUPLED WITH AN INTEREST, TO VOTE AT ANY MEETING OF THE STOCKHOLDERS OF THE COMPANY, HOWEVER
CALLED, OR ANY ADJOURNMENT THEREOF, OR BY WRITTEN CONSENT OF THE STOCKHOLDERS OF THE COMPANY, ALL VOTING SECURITIES OWNED BY SUCH STOCKHOLDER OR OVER WHICH SUCH STOCKHOLDER HAS VOTING CONTROL TO THE EXTENT NECESSARY TO CARRY OUT THE PROVISIONS OF
THIS SECTION 4 IN THE EVENT OF ANY BREACH BY SUCH STOCKHOLDER OF HIS, HER OR ITS OBLIGATIONS UNDER THE VOTING AGREEMENT CONTAINED HEREIN. 

4.5 Action by Stockholders. Each Stockholder further agrees that such Stockholder will not vote (in person, by proxy, pursuant to
written consent or otherwise) any Securities owned by such Stockholder or over which such Stockholder from time to time has voting control, in any manner which may circumvent the voting arrangements required by this
Section 4. 
 5. FIRST REFUSAL RIGHTS. 

5.1 Pre-Emptive Rights. 

(a) Except for (i) the issuance of Common Stock (or securities convertible into or containing options or rights to acquire shares of
Common Stock) (A) pursuant to an Initial Public Offering, (B) as consideration for the acquisition of all or any substantial portion of the assets or all or any portion of the capital stock of any Person, (C) upon conversion, exchange
or reclassification of 

  
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shares of one class or series of capital stock of the Company into shares of another class or series of capital stock of the Company, (D) to any current or former employee or director of the
Company or any of its Subsidiaries as employment-related compensation in a transaction approved by the Board of Directors, or (E) upon the exercise or redemption of any options, warrants or other rights to acquire shares of Common Stock which
are outstanding as of the Effective Time or upon the exercise of any options to acquire up to 11,500 shares of Common Stock authorized and reserved for issuance under the Company’s 2010 Equity Incentive Plan as of the Effective Time; or
(ii) Securities issued pursuant to the SPRA or any Securities issued upon the exercise or conversion of Securities issued pursuant to the SPRA, if the Company authorizes the issuance and sale of any shares of any class of Securities (other than
as a dividend, stock split, split-up or other distribution on the outstanding Common Stock) (such Securities, “Issuance Securities”), the Company will first offer to sell to each 5% Holder,
and each such 5% Holder shall have the right to purchase (the “Purchase Right”) at the price and on the terms set forth in the Issuance Notice (defined below), a pro rata portion of such Issuance Securities (based upon the
respective number of Securities then held by all 5% Holders on a fully diluted and as-converted to Common Stock basis, but excluding any shares of Common Stock issuable upon exercise of any options, warrants
or other rights to acquire shares of Common Stock then held by any Stockholders). 
 (b) Promptly after the Company authorizes the proposed
issuance and sale of the Issuance Securities, the Company shall notify (“Issuance Notice”) each 5% Holder in writing of such authorization, with such notification setting forth in reasonable detail the material terms of such
issuance, including the terms of the Issuance Securities, the purchase price therefor, the payment terms and such 5% Holder’s percentage allotment. Each 5% Holder (or applicable designee or delegee thereof) entitled to purchase Issuance
Securities must exercise such 5% Holder’s Purchase Right within thirty (30) days after delivery by the Company of the Issuance Notice (the “Pre-Emptive Right Notice Period”). 

(c) Upon the expiration of the Pre-Emptive Right Notice Period, if Purchase Rights have been exercised
by the 5% Holders with respect to some but not all of the Issuance Securities, then the Company shall immediately send written notice to those 5% Holders who timely and fully exercised their Purchase Rights (the “Exercising
Holders”). Each Exercising Holder shall have an additional right to purchase (“Secondary Purchase Right”) all or any part of the balance of any such remaining Issuance Securities on the terms and conditions specified in the
Issuance Notice. To exercise such Secondary Purchase Right, an Exercising Holder must provide written notice to the Company within ten (10) days after the Company’s delivery of such notice of the Secondary Purchase Right. In the event two
(2) or more Exercising Holders choose to exercise the Secondary Purchase Right for a total number of remaining Issuance Securities in excess of the number available, the remaining Issuance Securities available for purchase under this
Section 5.1(c) shall be allocated to such Exercising Holders pro rata based on the relative number of shares of Issuance Securities such Exercising Holders have elected to purchase pursuant to their respective
Secondary Purchase Right. 
 (d) Beginning fifteen (15) days after the expiration of the
Pre-Emptive Right Notice Period, for a period of ninety (90) days, the Company will be free to sell such Issuance Securities that the 5% Holders have not elected to purchase on terms and conditions no
more favorable to the purchasers thereof than those offered to such 5% Holders. Any Issuance Securities offered or sold by the Company after such ninety (90) day period must be reoffered to the 5% Holders entitled to purchase such Issuance
Securities pursuant to the terms of this Section 5. Any purchaser of Issuance Securities pursuant to this Section 5.3(d) that is not already a party hereto, as a condition precedent to the closing
of any such sale, shall have executed and delivered to the Company an Instrument of Accession. 

  
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 (e) Notwithstanding anything else contained in this Section 5 to
the contrary, each 5% Holder shall be entitled to assign or delegate its rights under this Section 5 to any of its Affiliates and any Designated Holder shall be entitled to assign or delegate its rights under this
Section 5 to its Affiliates or the other Designated Holder or its Affiliates; provided that such assignment or delegation would not violate Section 2.5, and subject to the last sentence of
Section 5.1(d). 
 6. COVENANTS. The Company and each Stockholder agrees to use its commercially reasonable
best efforts, within the requirements of applicable law, to ensure that the rights granted under this Agreement and the Charter are effective and that the parties enjoy the benefits of this Agreement and the Charter. Such actions include, without
limitation, the use of commercially reasonable best efforts to cause the nomination and election of the directors as provided in this Agreement. 

7. INFORMATION AND OBSERVER RIGHTS; SUBSIDIARIES. 

7.1 Delivery of Financial Statements. The Company shall deliver to each 5% Holder: 

(a) as soon as practicable, but in any event within one hundred and twenty (120) days after the end of each fiscal year of the Company,
(i) a balance sheet as of the end of such year, (ii) statements of income and of cash flows for such year, and a comparison between (x) the actual amounts as of and for such fiscal year and (y) the comparable amounts for the
prior year and as included in the Company’s Budget (as defined below) for such year, with an explanation of any material differences between such amounts and a schedule as to the sources and applications of funds for such year, and (iii) a
statement of stockholders’ equity as of the end of such year, all such financial statements audited and certified by independent public accountants selected by the Company and approved by the Board of Directors; 

(b) as soon as practicable, but in any event within forty-five (45) days after the end of each of the first three (3) quarters of
each fiscal year of the Company, (I) unaudited statements of income and of cash flows for such fiscal quarter, an unaudited balance sheet and a statement of stockholders’ equity as of the end of such fiscal quarter, all prepared in
accordance with U.S. generally accepted accounting principles (“GAAP”) (except that such financial statements may (i) be subject to normal year-end audit adjustments, and (ii) not
contain all notes thereto that may be required in accordance with GAAP), and (II) a then-current fully diluted equity capitalization table of the Company certified by the Company’s Chief Financial Officer as true and correct; 

(c) as soon as practicable, but in any event within thirty (30) days of the end of each month, a report from management of the Company in
form and substance reasonably satisfactory to the Designated Holders, an unaudited income statement and statement of cash flows for such month, and an unaudited balance sheet and statement of stockholders’ equity as of the end of such month,
all prepared in accordance with GAAP (except that such financial statements may (i) be subject to normal year-end audit adjustments, and (ii) not contain all notes thereto that may be required in
accordance with GAAP) and certified by the Company’s Chief Financial Officer; 

  
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 (d) as soon as practicable, but in any event thirty (30) days before the end of each
fiscal year, a budget and business plan for the next fiscal year (collectively, the “Budget”), approved by the Board of Directors and prepared on a monthly basis, including balance sheets, income statements, and statements of cash
flow for such months and, promptly after prepared, any other budgets or revised budgets prepared by the Company; 
 (e) with respect to any
financial statements called for in Section 7.1(a), Section 7.1(b), Section 7.1(c), and Section 7.1(d), an instrument executed by the Chief
Financial Officer and Chief Executive Officer or such other authorized officer of the Company certifying that such financial statements were prepared in accordance with GAAP consistently applied with prior practice for earlier periods (except as
otherwise set forth in Section 7.1(b) and Section 7.1(c)) and fairly present the financial condition of the Company and its results of operation for the periods specified therein; and 

(f) such other information relating to the financial condition, capitalization, business, prospects, or corporate affairs of the Company and
each Subsidiary as any 5% Holder may from time to time reasonably request; provided, however, that the Company shall not be obligated under this Section 7.1 to provide information (i) that the Company
reasonably determines in good faith to be a trade secret or confidential information (unless covered by an enforceable confidentiality agreement, in form reasonably acceptable to the Company) or (ii) the disclosure of which would adversely
affect the attorney-client privilege between the Company and its counsel. 
 If, for any period, the Company has any Subsidiary or Affiliate
whose accounts are consolidated with those of the Company, then in respect of such period the financial statements delivered pursuant to the foregoing sections shall be the consolidated and consolidating financial statements of the Company and all
such consolidated Subsidiaries or Affiliates. 
 Notwithstanding anything else in this Section 7.1 to the
contrary, the Company may cease providing the information set forth in this Section 7.1 during the period starting with the date thirty (30) days before the Company’s good-faith estimate of the date of filing of a
registration statement if it reasonably concludes it must do so to comply with the SEC rules applicable to such registration statement and related offering; provided that the Company’s covenants under this Section 7.1
shall be reinstated at such time as the Company is no longer actively employing its commercially reasonable efforts to cause such registration statement to become effective. 

7.2 Inspection. The Company shall permit each 5% Holder, at such 5% Holder’s expense, to visit and inspect the properties of the
Company and its Subsidiaries, examine their books of account and records (including equityholder ledgers and related records and materials), and discuss the affairs, finances, and accounts of the Company and its Subsidiaries with their respective
officers, in each case, during normal business hours of the Company or such Subsidiary as may be reasonably requested by such 5% Holder; provided, however, that the Company and its Subsidiaries shall not be obligated pursuant to this
Section 7.2 to provide access to any information that the Company reasonably and in good faith considers to be a trade secret or confidential information (unless covered by an enforceable confidentiality agreement, in form
reasonably acceptable to the Company) or the disclosure of which would adversely affect the attorney-client privilege between the Company or such Subsidiary and its counsel. Within five (5) days of any 5% Holder’s request, the Company
shall provide to such 5% Holder a then-current fully diluted equity capitalization table of the Company certified by the Company’s Chief Financial Officer as true and correct. 

  
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 7.3 Observer Rights. 

(a) For so long as Mitsui is a 5% Holder, (x) the Company shall, and shall cause each of its Subsidiaries to, invite up to two
(2) representatives of Mitsui to attend all meetings of the Board of Directors and each Subsidiary’s board of directors (or any committee of the foregoing), and (y) the Company shall use its reasonable best efforts to cause each of
Tecton and Pillar to invite one (1) representative of Mitsui to attend all meetings of the respective board of directors (or applicable governing body) of Tecton and Pillar (or any respective committees of the foregoing), in each case with
respect to (x) and (y), in a nonvoting observer capacity and, in this respect, shall give copies of all notices, minutes, consents, and other materials that it provides to directors (or other members of the applicable governing body) at the
same time and in the same manner as provided to such directors (or other members of the applicable governing body); provided, however, that each such representative shall agree in writing to a nondisclosure agreement in a reasonable
and customary form approved by the Company (provided any such agreement shall be in substantially the same form and no more restrictive than any similar agreement signed by the other directors or other members of the applicable governing body),
which shall provide that such representative will hold in confidence and trust all information so provided; and provided, further, that the Company, each Subsidiary, Tecton and Pillar may withhold any information and exclude such
representative from any meeting or portion thereof if access to such information or attendance at such meeting reasonably would adversely affect the attorney-client privilege between the Company, the respective Subsidiary, Tecton or Pillar and its
counsel or result in disclosure of trade secrets or a conflict of interest, as determined in good faith by the disinterested members of the Board of Directors, such Subsidiary’s board of directors, the board of directors (or applicable
governing body) of Tecton or the board of directors (or applicable governing body) of Pillar (as applicable). 
 (b) For so long as Kirin is
a 5% Holder, (x) the Company shall, and shall cause each of its Subsidiaries to, invite up to two (2) representatives of Kirin to attend all meetings of the Board of Directors and each Subsidiary’s board of directors (or any committee
of the foregoing), and (y) the Company shall use its reasonable best efforts to cause each of Tecton and Pillar to invite one (1) representative of Kirin to attend all meetings of the respective board of directors (or applicable governing
body) of Tecton and Pillar (or any respective committees of the foregoing), in each case with respect to (x) and (y), in a nonvoting observer capacity and, in this respect, shall give copies of all notices, minutes, consents, and other
materials that it provides to directors (or other members of the applicable governing body) at the same time and in the same manner as provided to such directors (or such other members of the applicable governing body); provided,
however, that each such representative shall agree in writing to a nondisclosure agreement in a reasonable and customary form approved by the Company (provided any such agreement shall be in substantially the same form and no more restrictive
than any similar agreement signed by the other directors or other members of the applicable governing body), which shall provide that such representative will hold in confidence and trust all information so provided; and provided,
further, that the Company, each Subsidiary, Tecton and Pillar may withhold any information and exclude such representative from any meeting or portion thereof if access to such information or attendance at such meeting reasonably would
adversely affect the attorney-client privilege between the Company, the respective Subsidiary, Tecton or Pillar and its 

  
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counsel or result in disclosure of trade secrets or a conflict of interest, as determined in good faith by the disinterested members of the Board of Directors, such Subsidiary’s board of
directors, the board of directors (or applicable governing body) of Tecton or the board of directors (or applicable governing body) of Pillar (as applicable). 

(c) For so long as ELUS is a 5% Holder, the Company shall, and shall cause each of its Subsidiaries to, invite a representative of ELUS to
attend all meetings of the Board of Directors and each Subsidiary’s board of directors (or any committee of the foregoing) in a nonvoting observer capacity and, in this respect, shall give copies of all notices, minutes, consents, and other
materials that it provides to directors at the same time and in the same manner as provided to such directors; provided, however, that such representative shall agree in writing to a nondisclosure agreement in a reasonable and
customary form approved by the Company (provided any such agreement shall be in substantially the same form and no more restrictive than any similar agreement signed by the other Directors), which shall provide that such representative will hold in
confidence and trust all information so provided; and provided, further, that the Company and each Subsidiary may withhold any information and exclude such representative from any meeting or portion thereof if access to such
information or attendance at such meeting reasonably would adversely affect the attorney-client privilege between the Company or the respective Subsidiary and its counsel or result in disclosure of trade secrets or a conflict of interest, as
determined in good faith by the disinterested members of the Board of Directors or such Subsidiary’s board of directors (as applicable). 

7.4 Subsidiaries. The Company shall, and shall cause each Subsidiary to, take all actions necessary or desirable to give effect to this
Agreement, the SPRA and the transactions contemplated hereby and thereby. 
 8. CONFIDENTIALITY. Each party hereby agrees to:
(a) hold in confidence and trust, and not disclose, any nonpublic, proprietary or confidential information of the Company and its Subsidiaries (the “Confidential Information”), (b) use the Confidential Information solely for
the benefit of the Company and its Subsidiaries, and (c) use its reasonable best efforts to ensure that any third party to which it provides such Confidential Information pursuant to this Section 8 shall hold such
information in confidence and trust and use such Confidential Information solely for the benefit of the Company and its Subsidiaries; provided, that a Stockholder may disclose confidential information (i) to its attorneys, accountants,
consultants, and other professionals to the extent necessary to obtain their services in connection with monitoring its investment or interest in the Company, provided such Persons are subject to professional duties of confidentiality or agree to be
bound by confidentiality and use restrictions with respect to the Confidential Information at least as restrictive as those set forth in this Section 8, (ii) to any existing or prospective Affiliate, partner, member,
stockholder, director or officer of such Stockholder or of any wholly owned subsidiary of such Stockholder in the ordinary course of business, provided that such Stockholder informs such Person that such information is confidential and such
Person agrees to be bound by confidentiality and use restrictions with respect to the confidential information at least as restrictive as those set forth in this Section 8, (iii) to any prospective transferee of such
Stockholder’s Securities (except, for clarity, to any transferee that would violate Section 2.5), provided that the prospective Transferee agrees to be bound by confidentiality and use restrictions with respect
to the confidential information at least as restrictive as those set forth in this Section 8, or (iv) to the extent required by law or regulation (including relevant securities laws and stock exchange listing
standards, rules or requirements); 

  
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provided, that in connection with any disclosure required by law, the Stockholder required to make such disclosure shall to the extent legally permissible provide prior written notice of
such required disclosure to the Company and shall take all reasonable and lawful actions to avoid and/or minimize the extent of such disclosure as may be reasonably requested by the Company. 

9. ADDITIONAL LEGEND. So long as any Securities are subject to the provisions hereof, all certificates or instruments representing such
Securities will have imprinted on them the following legend: 
 The shares represented by this certificate are subject to the terms of a
certain Fourth Amended and Restated Stockholder Agreement, dated as of July 5, 2018, among the issuer of this certificate and certain stockholders. The Stockholder Agreement contains certain restrictive provisions relating to the voting and
transfer of shares of the stock represented hereby. A copy of the Stockholder Agreement is on file at the Company’s principal offices. Upon written request to the Company’s Secretary, a copy of the Stockholder Agreement will be provided
without charge to appropriately interested persons, as determined by such Secretary. 
 10. SEVERABILITY. Whenever possible, each
provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule
in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such invalid, illegal or
unenforceable provision had never been contained herein. 
 11. ENTIRE AGREEMENT. Except as otherwise expressly set forth herein,
from and after the Effective Time and unless and until thereafter amended, this document will embody the complete agreement and understanding among the parties with respect to the subject matter hereof and upon the Effective Time will supersede and
preempt any prior understandings, agreements or representations by or among the parties, written or oral, with respect to such subject matter. 

12. SUCCESSORS AND ASSIGNS. This Agreement will bind and inure to the benefit of and be enforceable by the Company and the Stockholders
and their respective successors and assigns. 
 13. STOCK SPLITS, STOCK DIVIDENDS, ETC. In the event of any issuance of Securities
after the Effective Time to any of the Stockholders (including, without limitation, in connection with any stock split, stock dividend, recapitalization, reorganization, or the like), such Securities shall become subject to this Agreement and shall
be endorsed with the legend set forth in Section 9. 
 14. COUNTERPARTS; EFFECTIVENESS OF AGREEMENT. This
Agreement may be executed and delivered (including by email or facsimile) in separate counterparts each of which will be an original and all of which taken together will constitute one and the same agreement. This Agreement automatically shall
become effective as of the Effective Time, but automatically shall terminate and be deemed null and void ab initio if the SPRA is terminated or the Closing (as defined in the SPRA) otherwise does not occur for any reason. 

  
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 15. REMEDIES. The Stockholders will be entitled to enforce their rights under this
Agreement specifically (without posting a bond or other security), to recover damages by reason of any breach of any provision of this Agreement and to exercise all other rights existing in their favor. The parties hereto agree and acknowledge that
money damages may not be an adequate remedy for any breach of the provisions of this Agreement and that any Stockholder may in its sole discretion apply to any court of law or equity of competent jurisdiction for specific performance and/or
injunctive relief in order to enforce the terms of this Agreement or prevent any violation of the provisions of this Agreement. All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not
alternative. 
 16. AMENDMENT AND WAIVER. No modification, amendment or waiver of any provision of this Agreement will be effective
against the Company or the Stockholders unless (A) such modification, amendment or waiver is approved in writing by the Majority Stockholders; and (B) any provision of this Agreement that adversely changes the rights of any Stockholder
disproportionately to the other similarly situated Stockholders shall not be effective against such disproportionately adversely affected Stockholder, or enforced by the Company or any other Stockholders, unless such modification, amendment or
waiver is approved in writing by such disproportionately adversely affected Stockholder. Any provision hereof may be waived by the waiving party on such party’s own behalf, without the consent of any other party. Notwithstanding the foregoing,
no provision hereof, definition herein or rights hereunder in favor of, applicable to or for the express benefit of (i) Mitsui or its Affiliates may be amended or waived without the consent of Mitsui, (ii) Kirin or its Affiliates may be
amended or waived without the consent of Kirin, (iii) ELUS or its Affiliates may be amended or waived without the consent of ELUS, (iv) any 5% Holder may be amended or waived (for so long as such 5% Holder remains a 5% Holder) without the
consent of such 5% Holder, or (v) any Designated Holder may be amended or waived (for so long as such Designated Holder remains a Designated Holder) without the consent of such Designated Holder. Notwithstanding anything herein to the contrary,
the following actions shall not be taken without the consent of Non-Designated Stockholders holding a majority of the outstanding shares of Common Stock and Preferred Stock (voting together on an as-converted to Common Stock basis) then held by all Non-Designated Stockholders: (1) an amendment, modification or waiver of this Agreement to increase or decrease the
number of members of the Board of Directors; provided, that the Non-Designated Stockholders shall not unreasonably withhold, delay or condition approval of an increase to the number of members of the
Board of Directors in connection with a financing transaction approved by the Board of Directors (including at least one Non-K/M Director); (2) an amendment, modification or waiver of
Section 4(a)(iv) hereof or this fourth sentence of Section 16; (3) an amendment, modification or waiver of the definition of “Subsidiary”; or (4) an amendment, modification or waiver
of any provision hereof that adversely changes the rights of the Non-Designated Stockholders under either Section 2.6 or Section 2.7 hereof. The failure of any party to enforce
any of the provisions of this Agreement will in no way be construed as a waiver of such provisions and will not affect the right of such party thereafter to enforce each and every provision of this Agreement in accordance with its terms. The Company
shall give prompt written notice of any amendment, termination or waiver hereunder to any party that did not consent in writing thereto. 

17. EMPLOYMENT. Nothing contained in this Agreement is intended to create for any Stockholder who is an officer or employee of the
Company or a Subsidiary of the Company a right to continued employment with the Company or any of its Subsidiaries or employment in the same position or on the same terms as those currently in effect. 

  
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 18. TERMINATION. This Agreement will terminate upon the earliest to occur of
(a) the completion of any voluntary or involuntary liquidation or dissolution of the Company, (b) the completion of an Initial Public Offering, or (c) the consummation of an Approved Sale and distribution of proceeds to or the escrow
of such proceeds for the benefit of the Stockholders in accordance with the Charter. 
 19. GOVERNING LAW. ALL QUESTIONS
CONCERNING THE CONSTRUCTION, VALIDITY AND INTERPRETATION OF THIS AGREEMENT WILL BE GOVERNED BY THE LAWS OF THE STATE OF DELAWARE, WITHOUT REGARD TO PRINCIPLES OF CONFLICTS OF LAW. THE PARTIES AGREE TO WAIVE ANY RIGHT TO HAVE ANY DISPUTE ARISING
HEREUNDER OR OTHERWISE IN CONNECTION WITH THE TRANSACTIONS CONTEMPLATED HEREBY ADJUDICATED BY A JURY, AND HEREBY AGREE TO SUBMIT TO THE COURTS OF THE STATE OF DELAWARE IN CONNECTION WITH THE RESOLUTION OF ANY SUCH DISPUTE. 

20. DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement are inserted for convenience only and do not constitute a part of
this Agreement. 
 21. CONSTRUCTION. The language used in this Agreement will be deemed to be the language chosen by the parties to
express their mutual intent, and no rule of strict construction will be applied against any party. For purposes of this Agreement, (a) the words “include,” “includes” and “including” shall be deemed to be followed
by the words “without limitation”; (b) the word “or” is not exclusive; and (c) the words “herein,” “hereof,” “hereby,” “hereto” and “hereunder” refer to this Agreement as a
whole. Unless the context otherwise requires, references herein: (i) to Sections, Schedules and Exhibits mean the Sections of, and Schedules and Exhibits attached to, this Agreement; (ii) to an agreement, instrument or other document means
such agreement, instrument or other document as amended, supplemented and modified from time to time to the extent permitted by the provisions thereof, (iii) to a statute means such statute as amended from time to time and includes any
successor legislation thereto and any regulations promulgated thereunder, and (iv) to $ or Dollars mean United States Dollars. This Agreement shall be construed without regard to any presumption or rule requiring construction or interpretation
against the party drafting an instrument or causing any instrument to be drafted. The Schedules and Exhibits referred to herein shall be construed with, and as an integral part of, this Agreement to the same extent as if they were set forth verbatim
herein. 
 22. NOTICES. All notices and other communications given or made pursuant to this Agreement shall be in writing and shall
be deemed effectively given upon the earlier of actual receipt or (a) personal delivery to the party to be notified, (b) when sent, if sent by confirmed electronic mail or facsimile during normal business hours of the recipient, and if not
sent during normal business hours, then on the recipient’s next Business Day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) Business Day after
deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written verification of receipt: 

  
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 If to the Company, to: 

Thorne Holding Corp. 
 152 West
57th Street 
 New York, NY 10019 

Attn: Paul Jacobson 
 (917) 859-2505 
 Email: pjacobson@thorne.com 

With copies (which shall not constitute notice) sent contemporaneously to: 

Womble Bond Dickinson (US) LLP 

One West Fourth Street 

Winston-Salem, NC 27101 
 Attn:
Christopher J. Gyves 
 (336) 721-3634 

Email: christopher.gyves@wbd-us.com 

If to any Purchaser, to its address set forth on Schedule 2 or such other address as a Purchaser from time to time may specify to the Company
for purposes of notice. If to any other Stockholder, to the last address for such Stockholder on the Company’s official stockholder records. 

23. EMPLOYEE AGREEMENTS. The Company will cause each Person now or hereafter employed by it or by any Subsidiary (or engaged by the
Company or any Subsidiary as a consultant/independent contractor) with access to confidential information and/or trade secrets to enter into a nondisclosure and proprietary rights assignment agreement, substantially in a form approved by the Board
of Directors. In addition, the Company shall not amend, modify, terminate, waive, or otherwise alter, in whole or in part, any of the above-referenced agreements or any restricted stock agreement between the Company and any employee, without the
consent of the Board of Directors. 
 24. LEGAL MATTERS. The Company retained Womble Bond Dickinson (US) LLP (together with its
affiliates, “WBD”) in connection with the transactions contemplated herein. Further, the Company may retain WBD as legal counsel in connection with management and operations. Except as may have been expressly and specifically agreed
in writing by WBD, (a) WBD has not and is not representing any Stockholder or any director or officer of the Company in their individual capacities in connection with the transactions contemplated herein and the management and operation of the
Company or any dispute that may arise between any Stockholder or director or officer, on one hand, and the Company, on the other hand (the “Company Legal Matters”), and (b) WBD has not and is not providing any advice or counsel
(including legal advice or counsel), and shall not be deemed to have provided any advice or counsel, to any Stockholder or any director or officer of the Company in their individual capacities, in connection with the Company Legal Matters. Each
party has had the opportunity to engage its own independent counsel with respect to the transactions contemplated herein and will engage independent counsel to the extent it desires counsel in the future. 

25. THIRD PARTY BENEFICIARIES. The parties hereto agree that the agreements et forth herein are solely for the benefit of the parties
hereto, in accordance with and subject to the terms 

  
 -28- 

 
of this Agreement, and nothing expressed or implied in this Agreement is intended or shall be construed to confer upon or give any Person, other than the parties hereto, any right or remedies
under or by reason of this Agreement; provided, however, that, notwithstanding the foregoing, if (x) the Designated Holders fail to comply with their obligations set forth in Section 2.6 or
Section 2.7, (y) the Company has not taken action against the Designated Holders with respect to such failure and (z) after thirty (30) days’ written notice by the Management Representative (as defined in the
Management Holders Agreement, dated as of the date hereof, between the Company, the Management Representative, and the other parties thereto (the “MHA”)) to the Company and the Designated Holders of such noncompliance, the
Designated Holders failed to have cured such noncompliance, the Management Representative (as defined in the MHA), on behalf of the Management Holders (as defined in the MHA), so long as the Management Holders (as defined in the MHA) own Securities,
may rely upon and may directly enforce Section 2.6 or Section 2.7 (as the case may be) against the Designated Holders as an express third-party beneficiary to cause the Designated Holders to comply
with their obligations set forth in Section 2.6 and Section 2.7 (as the case may be). 

[Remainder of page intentionally left blank] 

  
 -29- 

 IN WITNESS WHEREOF, each of the undersigned has executed this Agreement or caused this
Agreement to be executed on its behalf as of the date first written above. 
  

			
	COMPANY:
	
	THORNE HOLDING CORP.
		
	By:	 	 /s/ Paul Jacobson

	Name:	 	Paul Jacobson
	Title:	 	Chief Executive Officer

  
 [Signature Page to
Stockholder Agreement] 

 
			
	INITIAL STOCKHOLDER:
	
	DIVERSIFIED NATURAL PRODUCTS, INC.
		
	By:	 	 /s/ Paul Jacobson

	Name:	 	Paul Jacobson
	Title:	 	Authorized Signatory

  
 [Signature Page to
Stockholder Agreement] 

 
			
	INITIAL STOCKHOLDER:
	
	ELUS HOLDING CORPORATION
		
	By:	 	 /s/ Riccardo Braglia

	Name:	 	Riccardo Braglia
	Title:	 	Chairman

  
 [Signature Page to
Stockholder Agreement] 

 
			
	INITIAL STOCKHOLDER:
	
	IDB HOLDING S.P.A
		
	By:	 	 /s/ Daniele Giavini

	Name:	 	Daniele Giavini
	Title:	 	General Manager

  
 [Signature Page to
Stockholder Agreement] 

 
			
	INITIAL STOCKHOLDER:
	
	MONASHEE CAPITAL MASTER FUND LP
		
	By:	 	 /s/ Tom Wynn

	Name:	 	Tom Wynn
	Title:	 	Partner

  
 [Signature Page to
Stockholder Agreement] 

 
			
	PURCHASER:
	
	KIRIN HOLDINGS COMPANY, LIMITED
		
	By:	 	 /s/ Keisuke Nishimura

	Name:	 	Keisuke Nishimura
	Title:	 	Senior Executive Vice President

  
 [Signature Page to
Stockholder Agreement] 

 
			
	PURCHASER:
	
	MITSUI & CO., LTD.
		
	By:	 	 /s/ Masami Yokoyama

	Name:	 	Masami Yokoyama
	Title:	 	General Manager, NutriScience Div.

  
 [Signature Page to
Stockholder Agreement] 

 Schedule 1 

Initial Stockholders 
  

			
	 Stockholder
	 	 Address

		
	 Diversified Natural Products, Inc. c/o Paul Jacobson
	 	 152 West 57th St.
 New York, NY
10019

		
	 ELUS Holding Corporation

c/o William Mann
	 	 170 Wood Avenue South
 5th Floor

Iselin, New Jersey 08830
 United States

 
 With copies of all notices to:

 
 Helsinn Healthcare, S.A.

P.O. Box 357
 6915 Lugano/Pambio-Noranco

Switzerland
 Attention: Matteo Missaglia, General Counsel

Facsimile: +41 (0) 91 993.21.22

		
	 IdB Holding S.p.A.
	 	 Viale Ortles 12
 20139 Milan,
Italy

		
	 Monashee Capital Master Fund LP
	 	 125 High Street
 High Street Tower,
28th Floor
 Boston, MA 02110

 Schedule 2 

Purchasers 
  

			
	 Mitsui & Co., Ltd.
	 	 c/o Yasutaka Yamakawa
 General
Manager, Food Science Dept. I
 Nutri Science Div. Nutrition & Agriculture Business Unit

1-3, Marunouchi 1-chome, Chiyoda-ku,
Tokyo 100-8631, Japan
 Facsimile:
+81-3-3285-9847
 E-mail:
Ya.Yamakawa@mitsui.com
  
 With a copy (which shall not constitute notice) to:

 
 Morgan, Lewis & Bockius LLP

300 South Grand Avenue, Twenty-Second Floor
 Los Angeles, CA
90071-3132
 Attention: John L. Filippone
 Facsimile: (213) 612-2501
 Email: john.filippone@morganlewis.com

		
	 Kirin Holdings Company, Limited
	 	 Kirin Holdings Company, Limited

Nakano Central Park South 4-10-2 Nakano

Nakano-ku, Tokyo 164-0001

 
 With a copy (which shall not constitute notice) to:

 
 Morrison & Foerster LLP

250 West 55th Street
 New York, New York 10019-9601

Attention: Stan Yukevich; Enrico Granata
 Email:
SYukevich@mofo.com;
 EGranata@mofo.com

 Exhibit A 

Instrument of Accession 

The undersigned, _______________, in order to become the owner or holder of ________ shares of [Preferred Stock] [Common Stock], [$0.01] par
value per share (the “Shares”), of Thorne Holding Corp., a Delaware corporation, hereby agrees to become a Subsequent Stockholder party to that certain Fourth Amended and Restated Stockholder Agreement, dated as of July 5, 2018
(the “Stockholder Agreement”), a copy of which is attached hereto. This Instrument of Accession shall become a part of such Stockholder Agreement. 

Executed as of the date set forth below under the laws of the State of Delaware. 

 

			
	Signature:	 	
                     

 
			
	Address:	 	
                     

	  

			
	  

	Date:	 	
                     

 Accepted: 
 THORNE HOLDING
CORP. 
  

			
	By:	 	
                     

			
	Date:

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