Document:

Second Amendment to Lease

 Exhibit 10.17 
 SECOND AMENDMENT TO LEASE 
 (High Bluff Ridge) 

THIS SECOND AMENDMENT TO LEASE (this “Amendment”) is made and entered into as of December 8, 2011 the
“Effective Date”), by and between PRII HIGH BLUFFS LLC, a Delaware limited liability company, and COLLINS CORPORATE CENTER PARTNERS, LLC, a Delaware limited liability company, as tenants in common (“Landlord”), and
CADENCE PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 
 R E C I
T A L S: 
 A. Prentiss/Collins Del Mar Heights LLC, a California limited
liability company (“Original Landlord”) and Tenant entered into that certain Office Lease dated as of May 12, 2006, as amended by that certain Amendment to Lease dated September 29, 2006 (as amended, the
“Lease”). Landlord has succeeded to the interest of Original Landlord under the Lease. Pursuant to, and as more particularly described in, the Lease, Landlord leases to Tenant certain space in a building located at 12481 High Bluff
Drive, San Diego, California (the “Building”), which space consists of approximately 23,494 rentable (22,405 usable) square feet, located on the second (2nd) floor of the Building and known as Suite 200 (the “Premises”), all as more particularly
described in the Lease. 
 B. Landlord and Tenant now desire to amend the Lease to, among other things, reduce the Premises
subject to the Lease and extend the Term. 
 A G R E E M E N T:

 NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
 1.
Defined Terms. Capitalized terms used herein without definition shall have the meanings set forth for such terms in the Lease. 
 2. Extension of Term. The Term is hereby extended for a fifteen (15) month period commencing on October 1, 2012 and expiring on December 31, 2013. 

3. Partial Termination of Lease. On September 30, 2012 (the “Partial Termination Date”), the Lease,
as amended hereby, shall terminate with respect to approximately 6,890 rentable square feet of the Premises (the “Give Back Space”), which Give Back Space is more particularly described as the “Give Back Space” on
Exhibit A attached hereto. On the Partial Termination Date, (a) Tenant shall surrender the Give Back Space to Landlord in the condition required under the terms of the Lease, as amended hereby (i.e., upon expiration or termination of the
Lease), (b) the Lease, as amended hereby, shall terminate with respect to the Give Back Space and (c) the parties hereto shall have no further rights or obligations with respect to the Give Back Space other than those rights and
obligations which survive the expiration or termination of the Lease, as amended hereby. From and after the Partial Termination Date all references in the Lease, as amended hereby, to the “Premises” shall be deemed to be references to
approximately 16,604, rentable square feet of the Premises (the “Renewal Space”), which Renewal Space is more particularly described as the “Renewal Space” on Exhibit A attached hereto. 

 4. Monthly Basic Rent. Notwithstanding anything to the contrary in the Lease,
commencing April 1, 2012, Monthly Basic Rent is as follows: 
  

					
	 Period
	  	 Monthly Basic Rent
	  	 Approximate Monthly

Basic Rent Per Rentable

Square Foot

	 04/01/12 – 09/30/12
	  	$90,451.90	  	$3.85
	 10/01/12 – 12/31/13
	  	$63,925.40	  	$3.85

 5. Parking. With respect to the period from and after the Partial Termination Date,
Section 1.16 of the Lease is amended and restated in its entirety to read as follows: 
 “1.16 Parking: A total
of sixty-six (66) parking privileges at the 12481 Building, which shall be comprised of (i) a minimum of forty-eight (48) unreserved, uncovered parking privileges at no additional cost to the Tenant, and (ii) a maximum of
eighteen (18) reserved, covered parking privileges at an additional cost to Tenant of $100 per stall per month. All such parking privileges shall be subject to the provisions set forth in Section 6.2 of this Lease.” 

6. Tenant’s Percentage. With respect to the period from and after the Partial Termination Date, the defined term,
“Tenant’s Percentage” shall mean 10.51%. 
 7. No Extension Option. Section 37 of the Lease is
deleted in its entirety. Tenant has no right to extend the Term. 
 8. Condition of Premises. Tenant hereby agrees
to accept the Premises in their “as-is” condition, and Tenant hereby acknowledges that Landlord shall not be obligated to provide or pay for any work or services related to the maintenance, repair or improvement of the Premises. Tenant
also acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty regarding the condition of all or any portion of the Premises. 
 9. Anti-Terrorism Representations. 
 9.1 Tenant is not, and shall
not during the Term become, a person or entity with whom Landlord is restricted from doing business under the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001, H. R. 3162,
Public Law 107-56 (commonly known as the “USA Patriot Act”) and Executive Order Number 13224 on Terrorism Financing, effective September 24, 2001 and regulations promulgated pursuant thereto (collectively, “Anti-Terrorism
Laws”), including without limitation persons and entities named on the Office of Foreign Asset Control Specially Designated Nationals and Blocked Persons List (collectively, “Prohibited Persons”). 

9.2 To the best of its knowledge, Tenant represents and warrants to Landlord that it is not currently engaged in any transactions or
dealings, or otherwise associated with, any 

  
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Prohibited Persons in connection with the use or occupancy of the Premises or the Project. Tenant covenants that it will not, during the Term knowingly engage in any transactions or dealings, or
be otherwise associated with, any Prohibited Persons in connection with the use or occupancy of the Premises or the Project. 

9.3 Tenant acknowledges and agrees that as a condition to the effectiveness of an assignment of, or sublease under, the Lease, as amended
hereby, and to the requirement or effectiveness of any consent to assignment or sublease by Landlord, Tenant shall cause the assignee or sublessee to make, on behalf of such assignee or sublessee for the benefit of Landlord, the representations set
forth in Section 36 of the Lease and this Section 9, and it shall be reasonable for Landlord to refuse to consent to an assignment of, or sublease under, the Lease, as amended by this Amendment, in the absence of such
representations by any such assignee or sublessee. 
 10. Miscellaneous. 

(a) Entire Agreement. This Amendment embodies the entire understanding between Landlord and Tenant with respect to its subject
matter and can be changed only by an instrument in writing signed by Landlord and Tenant. 
 (b) Counterparts. This
Amendment may be executed in counterparts, including facsimile counterparts, each of which shall be deemed an original, but all of which, together, shall constitute one and the same Amendment. 

(c) Brokers. Tenant represents and warrants that it has been represented by Studley, Inc. (Tenant’s Broker”) in
connection with this Amendment. If the transactions contemplated by this Amendment are consummated, subject to the terms of Landlord’s separate agreement with Tenant’s Broker, Landlord shall pay Tenant’s Broker a commission. Except as
described herein, Landlord shall have no further or separate obligation for payment of commissions or fees to any other real estate broker, finder or intermediary, including, without limitation, any commissions or fees in connection with the ROFO or
the Option. Tenant represents and warrants to the other, that no other broker, agent or finder (a) negotiated or was instrumental in negotiating or consummating this Amendment on its behalf, and (b) is or might be entitled to a commission
or compensation in connection with this Amendment as a result of its actions or inactions. Tenant shall indemnify, protect, defend (by counsel reasonably approved in writing by Landlord) and hold Landlord harmless from and against any and all
claims, judgments, suits, causes of action, damages, losses, liabilities and expenses (including attorneys’ fees and court costs) resulting from any breach by Tenant of the foregoing representation, including, without limitation, any claims
that may be asserted against Landlord by any broker, agent or finder undisclosed by Tenant herein. The Section 10 shall survive the expiration or earlier termination of the Lease, as amended by this Amendment. 

(d) Defaults. Tenant hereby represents and warrants to Landlord that each of Landlord and Tenant is in full compliance with all
terms, covenants and conditions of the Lease and that there are no breaches or defaults under the Lease by Landlord or Tenant, and that Tenant knows of no events or circumstances which, given the passage of time, would constitute a breach or default
under the Lease by either Landlord or Tenant. 

  
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 (e) Authority. Each individual executing this Amendment for the Tenant represents
that he or she is duly authorized to execute and deliver this Amendment for the Tenant and the Amendment is binding upon the Tenant, its successors and assigns in accordance with its terms. 

(f) Reaffirmation of Obligations. Landlord and Tenant each hereby acknowledges and reaffirms all of its obligations under the
Lease, as such Lease has been amended by this Amendment, and agrees that any reference made in any other document to the Lease shall mean the Lease as amended pursuant to this Amendment. Except as expressly provided herein, the Lease remains
unmodified and in full force and effect. The Lease shall remain in full force and effect and binding upon the parties hereto except as otherwise addressed herein. Any breach of this Amendment, including any exhibit hereto, shall constitute a breach
and default under the Lease. 
 (g) Miscellaneous. Time is of the essence in this Amendment and the Lease and each and
all of their respective provisions. The agreements, conditions and provisions herein contained shall apply to and bind the heirs, executors, administrators, successors and assigns of the parties hereto. If any provisions of this Amendment or the
Lease shall be determined to be illegal or unenforceable, such determination shall not affect any other provision of the Lease or this Amendment and all such other provisions shall remain in full force and effect. If there is any inconsistency
between the provisions of this Amendment and the other provisions of the Lease, the provisions of this Amendment shall control with respect to the subject matter of this Amendment. This Amendment constitutes a part of the Lease. 

  
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 IN WITNESS WHEREOF, the parties have executed this Amendment as of the date and year first
set forth above. 
 LANDLORD: 
 PRII HIGH BLUFFS LLC, a Delaware limited liability company, 
 as Owner Agent

  

			
	By:	  	The Prudential Insurance Company of America, an insurance company organized under the laws of the State of New Jersey, acting solely on behalf of, and for the benefit of, and
with its liability limited to the assets of, its insurance company separate account PRISA II, its Sole Member

  

			
	By:	  	 /s/ Justin C. Chapman

	Name:	  	 Justin C. Chapman

	Title:	  	 Vice President

 TENANT: 
 CADENCE PHARMACEUTICALS, INC., a Delaware corporation 
  

			
	By:	  	 /s/ William R. LaRue

	Name:	  	 William R. LaRue

	Title:	  	 SVP, Chief Financial Officer

		
	By:	  	 /s/ Theodore R. Schroeder

	Name:	  	 Theodore R. Schroeder

	Title:	  	 President and Chief Executive Officer

  
 5Sixth Supplemental Indenture, dated as of March 13, 2012

 Exhibit 4.1 
 R.R. DONNELLEY & SONS COMPANY 
 and 

WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee 

 
  

SIXTH SUPPLEMENTAL INDENTURE 
 Dated as of March 13, 2012 
 to 

Indenture dated as of January 3, 2007 
  

 
 $450,000,000
8.25% Notes due 2019 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	ARTICLE I	  
	DEFINITIONS	  
			
	 SECTION 1.1
	 	Generally	  	 	1	  
			
	 SECTION 1.2
	 	Definition of Certain Terms	  	 	1	  
	
	ARTICLE II	  
	GENERAL TERMS OF THE NOTES	  
			
	 SECTION 2.1
	 	Form	  	 	4	  
			
	 SECTION 2.2
	 	Amount and Payment of Principal and Interest	  	 	4	  
			
	 SECTION 2.3
	 	Denominations	  	 	4	  
			
	 SECTION 2.4
	 	Global Securities	  	 	5	  
			
	 SECTION 2.5
	 	Payment, Transfer and Exchange	  	 	5	  
			
	 SECTION 2.6
	 	Registrar and Paying Agent	  	 	5	  
			
	 SECTION 2.7
	 	Ranking	  	 	5	  
			
	 SECTION 2.8
	 	Events of Default	  	 	5	  
			
	 SECTION 2.9
	 	Trustee’s Right to Refuse Directions in Certain Circumstances	  	 	6	  
	
	ARTICLE III	  
	REDEMPTION	  
			
	 SECTION 3.1
	 	Redemption	  	 	6	  
			
	 SECTION 3.2
	 	Redemption Procedures	  	 	6	  
			
	 SECTION 3.3
	 	Notice of Redemption	  	 	7	  
	
	ARTICLE IV	  
	CHANGE OF CONTROL	  
			
	 SECTION 4.1
	 	Change of Control	  	 	7	  
	
	ARTICLE V	  
	MISCELLANEOUS PROVISIONS	  
			
	 SECTION 5.1
	 	Ratification of Base Indenture	  	 	9	  
			
	 SECTION 5.2
	 	Trustee Not Responsible for Recitals	  	 	9	  
			
	 SECTION 5.3
	 	Table of Contents, Headings, etc.	  	 	9	  
			
	 SECTION 5.4
	 	Counterpart Originals	  	 	9	  
			
	 SECTION 5.5
	 	Governing Law	  	 	10	  
			
	 EXHIBIT A-1
	 	Form of Note	  	 	A-1	  

  
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 THIS SIXTH SUPPLEMENTAL INDENTURE, dated as of March 13, 2012 (the “Sixth
Supplemental Indenture”), between R.R. Donnelley & Sons Company, a Delaware corporation, as issuer (the “Company”), and Wells Fargo Bank, National Association, a national banking association, as trustee (the
“Trustee”). 
 RECITALS: 
 WHEREAS, the Company has executed and delivered to the Trustee an Indenture, dated as of January 3, 2007 (the “Base Indenture” and, as supplemented by this Sixth Supplemental
Indenture, the “Indenture”), providing for the issuance by the Company from time to time of its unsecured senior debentures, notes or other evidences of indebtedness to be issued in one or more series unlimited as to principal
amount (the “Securities”); 
 WHEREAS, the Company has duly authorized and desires to cause to be established
pursuant to the Base Indenture and this Sixth Supplemental Indenture a new series of Securities designated the “8.25% Notes due 2019” (the “Notes”), the form and terms of such Notes to be set forth in this Sixth
Supplemental Indenture; 
 WHEREAS, all things necessary to make this Sixth Supplemental Indenture a valid agreement of the
Company and the Trustee, in accordance with its terms, and a valid amendment of, and supplement to, the Base Indenture have been done; 
 NOW, THEREFORE, in consideration of the premises and the purchase and acceptance of the Notes by the Holders thereof, the Company covenants and agrees with the Trustee, for the equal and ratable benefit
of the Holders, that the Base Indenture is supplemented and amended, to the extent expressed herein, as follows: 
 ARTICLE I

 DEFINITIONS 
 SECTION 1.1 Generally. 
 (a) Capitalized terms used herein and not otherwise
defined herein shall have the respective meanings ascribed thereto in the Base Indenture. 
 (b) The rules of interpretation set
forth in the Base Indenture shall be applied hereto as if set forth in full herein. 
 SECTION 1.2 Definition of Certain Terms. 

For all purposes of this Sixth Supplemental Indenture, except as otherwise expressly provided or unless the context otherwise requires,
the following terms shall have the following respective meanings: 
 “Adjusted Treasury Rate” means, with
respect to any Redemption Date, the rate per year equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to
the Comparable Treasury Price for that Redemption Date. 

 “Below Investment Grade Rating Event” means the Notes
are rated below an Investment Grade Rating by each of the Rating Agencies on the 60th day following the occurrence of a Change of Control (which date shall be extended if the rating of the Notes is under publicly announced consideration for possible downgrade by any of the Rating Agencies
on such 60th day, such extension to last until the date on
which the Rating Agency considering such possible downgrade either (x) rates the Notes below an Investment Grade Rating or (y) publicly announces that it is no longer considering the Notes for possible downgrade; provided, that no such
extension shall occur if any of the Rating Agencies rates the Notes with an Investment Grade Rating that is not subject to review for possible downgrade on such 60th day). 
 “Change of Control” means the occurrence of any of the following: (1) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or
consolidation), in one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its Subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the
Exchange Act) other than the Company or one of its Subsidiaries; (2) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in
Section 13(d)(3) of the Exchange Act) becomes the beneficial owner, directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s voting stock; or (3) the first day on which a majority of the
members of the Company’s Board of Directors are not Continuing Directors. 
 “Change of Control Offer”
means an offer to repurchase Notes pursuant to Section 4.1 hereof. 
 “Change of Control Payment” means,
with respect to Notes tendered for repurchase pursuant to a Change of Control Offer, an amount equal to 101% of the aggregate principal amount of such Notes plus accrued and unpaid interest thereon, if any, to the date of repurchase. 

“Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade
Rating Event. 
 “Comparable Treasury Issue” means the United States Treasury security selected by the
Quotation Agent as having a maturity comparable to the remaining term of the Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of those Notes. 
 “Comparable Treasury Price” means,
with respect to any Redemption Date, (1) the average of the Reference Treasury Dealer Quotations for that Redemption Date, after excluding the highest and lowest Reference Treasury Dealer Quotations, or (2) if the Quotation Agent obtains
fewer than four Reference Treasury Dealer Quotations, the average of all Reference Treasury Dealer Quotations so received. 

  
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 “Continuing Directors” means, as of any date of determination, any member
of the Board of Directors of the Company who (1) was a member of such Board of Directors on the date of the issuance of the Notes; or (2) was nominated for election or elected to such Board of Directors with the approval of a majority of
the Continuing Directors who were members of such Board of Directors at the time of such nomination or election (either by a specific vote or by approval of the Company’s proxy statement in which such member was named as a nominee for election
as a director, without objection to such nomination). 
 “Investment Grade Rating” means a rating equal to or
higher than Baa3 (or the equivalent) by Moody’s and BBB- (or the equivalent) by S&P. 
 “Moody’s”
means Moody’s Investors Service, Inc., a subsidiary of Moody’s Corporation, and its successors. 

“Person” means any individual, partnership, corporation, limited liability company, joint stock company, business trust,
trust, unincorporated association, joint venture or other entity, or a government or political subdivision or agency thereof. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Company. 

“Rating Agencies” means (1) each of Moody’s and S&P; and (2) if any of Moody’s or S&P ceases
to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) under the
Exchange Act, selected by the Company (as certified by a resolution of the Company’s Board of Directors) as a replacement agency for Moody’s or S&P, or both of them, as the case may be. 

“Reference Treasury Dealer” means (1) each of Merrill Lynch, Pierce, Fenner & Smith Incorporated, J.P.
Morgan Securities LLC and a Primary Treasury Dealer selected by Wells Fargo Securities, LLC and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in New York
City (a “Primary Treasury Dealer”), the Company shall substitute another Primary Treasury Dealer, and (2) any one other Primary Treasury Dealer selected by the Company. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Quotation Agent, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Quotation Agent by that Reference Treasury
Dealer at 5:00 p.m., New York City time, on the third Business Day preceding that Redemption Date. 
 “S&P”
means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and its successors. 

  
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 ARTICLE II 
 GENERAL TERMS OF THE NOTES 
 SECTION 2.1 Form. 

The Notes and the Trustee’s certificates of authentication shall be substantially in the form of Exhibit A-1 to
this Sixth Supplemental Indenture, which are hereby incorporated into this Sixth Supplemental Indenture. The terms and provisions contained in the Notes shall constitute, and are hereby expressly made, a part of this Sixth Supplemental Indenture and
to the extent applicable, the Company and the Trustee, by their execution and delivery of this Sixth Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. 

SECTION 2.2 Amount and Payment of Principal and Interest. 
 (a) The Trustee shall authenticate and deliver the Notes for original issue on the date hereof in the aggregate principal amount of $450,000,000. The principal amount of each Note shall be payable on
March 15, 2019. 
 (b) The Notes shall bear interest at 8.25% per year beginning on the date of issuance until the
Notes are redeemed, paid, or duly provided for. Interest shall be paid semiannually in arrears on March 15 and September 15 of each year (each an “Interest Payment Date”), commencing on September 15, 2012. The regular
record date for interest payable on the Notes shall be the March 1 and September 1, as the case may be, immediately preceding each Interest Payment Date. Interest will be computed on the basis of a 360-day year comprised of twelve 30-day
months. Any payment of principal or interest required to be made on a day that is not a Business Day need not be made on such day, but may be made on the next succeeding Business Day with the same force and effect as if made on such day and no
interest shall accrue as a result of such delayed payment. 
 (c) Subject to the terms and conditions contained herein, the
Company may from time to time, without the consent of the existing Holders create and issue additional Notes (the “Additional Notes”) having the same terms and conditions as the Notes in all respects, except for issue date and the
first payment of interest thereon. Such Additional Notes, at the Company’s determination and in accordance with the provisions of the Indenture, will be consolidated with and form a single series with the previously outstanding Notes for all
purposes under the Indenture, including, without limitation, amendments, waivers and redemptions. The aggregate principal amount of the Additional Notes, if any, shall be unlimited. 
 SECTION 2.3 Denominations 
 The Notes will be issuable only in fully
registered form without coupons in denominations of $2,000 and any integral multiples of $1,000 in excess thereof. 

  
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 SECTION 2.4 Global Securities 

The Notes will be issuable in the form of one or more Global Securities and the Depository for such Global Securities will be The
Depository Trust Company in accordance with the Base Indenture. 
 SECTION 2.5 Payment, Transfer and Exchange 

(a) The principal and interest on Notes represented by Global Securities will be payable to the Depository or its nominee, as the case
may be, as the sole registered owner and the sole Holder of the Global Securities represented thereby. The principal and interest on Notes represented by Physical Securities will be payable, either in person or by mail, at the office of the Paying
Agent. 
 (b) Transfers of Global Securities will be limited to transfer in whole, but not in part, to the Depository, its
successors or their respective nominees. Interests of beneficial owners in the Global Securities may be transferred or exchanged for Physical Securities in accordance with the Indenture. If Notes represented by Physical Securities are presented to
the Registrar with a request from the Holder of such Securities to register a transfer or to exchange them for an equal principal amount of Securities of other authorized denominations, the Registrar will register the transfer as requested in
accordance with the Indenture. 
 SECTION 2.6 Registrar and Paying Agent 

The Company initially appoints the Trustee as Registrar and Paying Agent. The Company may change the Paying Agent and Registrar without
notice to Holders. 
 SECTION 2.7 Ranking 
 The Notes will be senior unsecured obligations of the Company. The payment of the principal of, premium, if any, and interest on the Notes will (i) rank equally in right of payment with all other
indebtedness of the Company that is not by its terms expressly subordinated to other indebtedness of the Company, and (ii) rank senior in right of payment to all indebtedness of the Company that is, by its terms, expressly subordinated to the
senior indebtedness of the Company. 
 SECTION 2.8 Events of Default 

With respect to the Notes, Section 6.02 of the Base Indenture shall be amended by deleting from the parenthetical contained in the
first sentence of Section 6.02 the phrase “an Event of Default specified in Section 6.01(3) with respect to Section 4.08 or” and such phrase shall not be applicable to the Notes. 

  
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 SECTION 2.9 Trustee’s Right to Refuse Directions in Certain Circumstances. 

With respect to directions given by the Holders of a majority in principal amount pursuant to the Indenture to the Trustee in its
exercise of any trust or power, the Trustee will be entitled to refuse to follow any such direction that conflicts with law or the Indenture or that the Trustee determines in good faith is unduly prejudicial to the rights of other Holders or could,
in reasonable likelihood, impose personal liability upon the Trustee, unless the Trustee is offered indemnity satisfactory to it. 
 ARTICLE III 
 REDEMPTION 

SECTION 3.1 Redemption. 

(a) Except as provided in this Article III, the Company shall have no obligation to redeem, purchase or repay the Notes pursuant to any
mandatory redemption, sinking fund or analogous provisions or at the option of a Holder thereof. 
 (b) The Notes are subject to
redemption at any time or from time to time, in whole or in part, at the Company’s option at a Redemption Price equal to the greater of (i) 100% of the principal amount of the Notes to be redeemed, and (ii) as determined by the
Quotation Agent, the sum of the present values of the remaining scheduled payments of principal and interest in respect of the Notes to be redeemed (not including any portion of those payments of interest accrued as of the date of redemption)
discounted to the date of redemption on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Adjusted Treasury Rate plus 50 basis points, plus accrued interest to the Redemption Date. The Company may provide in
such notice that payment of such Redemption Price and performance of the Company’s obligations with respect to such redemption or purchase may be performed by another Person. Any such notice may, at the Company’s discretion, be subject to
the satisfaction of one or more conditions precedent. 
 SECTION 3.2 Redemption Procedures. 

The Trustee will select Notes called for redemption in part on a pro rata basis or on as nearly a pro rata basis as is practicable
(subject to procedures of the Depository); provided that Notes in principal amounts of $2,000 or less shall be redeemed in whole and not in part. In the case of Notes represented by Physical Securities, a new Note in principal amount equal to the
unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of the original Note. In the case of Notes represented by a Global Security, the outstanding principal amount of the Global Security representing the Notes
will be reduced by book-entry. Notes called for redemption become due on the Redemption Date. On and after the Redemption Date, interest stops accruing on Notes or portions of them called for redemption (unless there is a default in the payment
thereof). 

  
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 SECTION 3.3 Notice of Redemption. 

(a) At the Company’s written request made at least 45 days prior to the Redemption Date (unless a shorter notice shall be agreed to
in writing by the Trustee), the Trustee shall give the notice of redemption in the Company’s name and at the Company’s sole expense. 
 (b) Notices of redemption shall be mailed by first class mail at least 30 but not more than 60 days before the Redemption Date to each Holder of Notes to be redeemed at its registered address. If any Note
is to be redeemed in part only, the notice of redemption that relates to such Note shall state the portion of the principal amount thereof to be redeemed. 
 (c) Any notice to holders of Notes of any redemption will include the appropriate calculation of the Redemption Price, but does not need to include the Redemption Price itself. The actual Redemption
Price, calculated as described above, will be set forth in an Officers’ Certificate of the Company delivered to the Trustee no later than two Business Days prior to the Redemption Date 

ARTICLE IV 

CHANGE OF CONTROL 

SECTION 4.1 Change of Control. 
 (a) Upon the occurrence of a Change of Control Triggering Event, unless all Notes have been called for redemption, each Holder of Notes shall have the right to require the Company to repurchase all or any
part (equal to $2,000 or an integral multiple of $1,000 in excess thereof) of such Holder’s Notes at an offer price in cash equal to the Change of Control Payment. 
 (b) Within 30 days following any Change of Control Triggering Event, the Company shall mail, or cause to be mailed, a notice to the Trustee and to each Holder describing the transaction or transactions
that constitute the Change of Control Triggering Event and specifying: 
 (i) that the Change of Control Offer is
being made pursuant to this Section 4.1 and that all Notes tendered will be accepted for payment; 
 (ii)
the Change of Control Payment and the purchase date, which shall be a Business Day no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”); 

(iii) the CUSIP number for the Notes; 

(iv) that any Note not tendered will continue to accrue interest; 

  
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 (v) that, unless the Company defaults in the payment of the Change of
Control Payment, all Notes accepted for payment pursuant to the Change of Control Offer will cease to accrue interest after the Change of Control Payment Date; 
 (vi) that Holders electing to have any Notes purchased pursuant to a Change of Control Offer will be required to surrender such Notes to the Paying Agent at the address specified in the notice prior to
the close of business on the third Business Day preceding the Change of Control Payment Date; 
 (vii) that
Holders will be entitled to withdraw their election referred to in clause (vi) if the Paying Agent receives, not later than the close of business on the second Business Day preceding the Change of Control Payment Date, a facsimile transmission
or letter setting forth the name of the Holder, the principal amount of Notes delivered for purchase, and a statement that such Holder is withdrawing his election to have the Notes purchased; and 

(viii) that Holders whose Notes are being purchased only in part will be issued new Notes equal in principal amount to the
unpurchased portion of the Notes surrendered, which unpurchased portion will be equal to $2,000 in principal amount or an integral multiple of $1,000 in excess thereof. 
 (c) The Company shall cause the Change of Control Offer to remain open for at least 20 Business Days or such longer period as is required by applicable law. The Company shall comply with the requirements
of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event.
To the extent that the provisions of any securities laws or regulations conflict with the provisions of this Section 4.1, the Company will comply with the applicable securities laws and regulations and will not be deemed to have breached its
obligations under this Section 4.1 by virtue of such conflict. 
 (d) On the Change of Control Payment Date, the Company
will, to the extent lawful: 
 (i) accept for payment all Notes or portions thereof properly tendered pursuant to
the Change of Control Offer; 
 (ii) deposit with the Paying Agent an amount equal to the Change of Control
Payment in respect of all Notes or portions of Notes properly tendered; and 
 (iii) deliver or cause to be
delivered to the Trustee the Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes or portions of Notes being purchased by the Company. 

  
 -8-

 (e) The Paying Agent will promptly mail to each Holder of Notes properly tendered the Change
of Control Payment for such Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book entry) to each Holder a new Note equal in principal amount to any unpurchased portion of the Notes surrendered, if any;
provided that each new Note will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof. The Company will publicly announce the results of the Change of Control Offer on or as soon as practicable after the
Change of Control Payment Date. 
 (f) The Company shall not be required to make a Change of Control Offer upon a Change of
Control Triggering Event if a third party makes the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this Section 4.1 applicable to a Change of Control Offer made by the Company
and purchases all Notes properly tendered and not withdrawn under such Change of Control Offer. 
 (g) The Company may make a
Change of Control Offer in advance of, but conditioned on, the occurrence of a Change of Control Triggering Event but otherwise in accordance with the provisions of this Section 4.1. 

ARTICLE V 

MISCELLANEOUS PROVISIONS 

SECTION 5.1 Ratification of Base Indenture. 
 The Base Indenture, as supplemented by this Sixth Supplemental Indenture, is in all respects ratified and confirmed, and this Sixth Supplemental Indenture shall be deemed part of the Base Indenture in the
manner and to the extent herein and therein provided. 
 SECTION 5.2 Trustee Not Responsible for Recitals. 

The recitals contained herein and in the Notes, except with respect to the Trustee’s certificates of authentication, shall be taken
as the statements of the Company, and the Trustee assumes no responsibility for the correctness of the same. The Trustee makes no representations as to the validity or sufficiency of this Sixth Supplemental Indenture or of the Notes. 

SECTION 5.3 Table of Contents, Headings, etc. 
 The table of contents and headings of the Articles and Sections of this Sixth Supplemental Indenture have been inserted for convenience of reference only, are not to be considered a part hereof and shall
in no way modify or restrict any of the terms or provisions hereof. 
 SECTION 5.4 Counterpart Originals. 

The parties may sign any number of copies of this Sixth Supplemental Indenture. Each signed copy shall be an original, but all of them
together represent the same agreement. 

  
 -9-

 SECTION 5.5 Governing Law. 
 THIS SIXTH SUPPLEMENTAL INDENTURE AND THE NOTES SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 

[Signature Pages Follow] 

  
 -10-

 IN WITNESS WHEREOF, the parties have caused this Sixth Supplemental Indenture to be duly
executed all as of the date and year first written above. 
  

			
	R.R. DONNELLEY & SONS COMPANY
		
	By:	 	/s/ Daniel Lieb
		 	Name: Daniel Lieb
		 	Title: Chief Financial Officer

 [Sixth Supplemental Indenture] 

 
			
	 WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee

		
	By:	 	/s/ Gregory G. Clarke
		 	Name: Gregory G. Clarke
		 	Title: Vice President

 [Sixth Supplemental Indenture] 

 EXHIBIT A-1 
 THIS NOTE IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITORY OR A NOMINEE THEREOF. THIS NOTE MAY NOT BE EXCHANGED IN WHOLE OR IN
PART FOR A NOTE REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITORY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE.

 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO., OR SUCH OTHER NAME AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY AND ANY PAYMENT HEREON IS
MADE TO CEDE & CO., ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

CUSIP No.: 257867 AY7 
 ISIN No.: US257867AY73

 R.R. DONNELLEY & SONS COMPANY 
  

					
	No. ____	  	 	$____________	  

 8.25% NOTE DUE 2019 
 R.R. DONNELLEY & SONS COMPANY, a Delaware corporation, as issuer (the “Company”), for value received, promises to pay to CEDE & CO. or registered assigns the principal
sum of $                     on March 15, 2019. 
 Interest Payment Dates: March 15 and September 15, commencing September 15, 2012. 
 Record Dates: March 1 and September 1. 

  
 A-1-1

 Reference is made to the further provisions of this Note contained herein, which will for
all purposes have the same effect as if set forth at this place. 

  
 A-1-2

 IN WITNESS WHEREOF, the Company has caused this Note to be signed manually or by facsimile
by one of its duly authorized officers. 
 Dated: 

 

			
	R.R. DONNELLEY & SONS COMPANY
		
	By:	 	 
		 	Name:
		 	Title:

  
 A-1-3

 Certificate of Authentication 

This is one of the 8.25% Notes due 2019 referred to in the within-mentioned Indenture. 

 

			
	 WELLS FARGO BANK, NATIONAL ASSOCIATION,
as Trustee

		
	By:	 	 

 Dated: 

  
 A-1-4

 [FORM OF REVERSE OF NOTE] 

R.R. DONNELLEY & SONS COMPANY 
 8.25% NOTE DUE 2019 
 1. Interest. R.R. DONNELLEY & SONS COMPANY,
a Delaware corporation, as issuer (the “Company”), promises to pay, until the principal hereof is paid or made available for payment, interest on the principal amount set forth on the face hereof at a rate of 8.25% per annum.
Interest hereon will accrue from and including the most recent date to which interest has been paid or, if no interest has been paid, from and including March 13, 2012 to but excluding the date on which interest is paid. Interest shall be
payable in arrears on March 15 and September 15 of each year, commencing September 15, 2012. Interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. The Company shall pay interest on overdue
principal and on overdue interest (to the full extent permitted by law) at the rate borne by the Notes. 
 2. Method of
Payment. The Company will pay interest hereon (except defaulted interest) to the Persons who are registered Holders at the close of business on the March 1 and September 1 immediately preceding the interest payment date (whether or not
a Business Day). Holders do not have to surrender Notes to a Paying Agent to collect principal payments. The Company will pay to the Paying Agent principal and interest in money of the United States of America that at the time of payment is legal
tender for payment of public and private debts. If a Holder has given wire transfer instructions to the Company, the Company will pay, or cause to be paid by the Paying Agent, all principal (and premium, if any) and interest on that Holder’s
Notes in accordance with those instructions. All other payments on the Notes will be made at the office or agency of the Paying Agent and Registrar unless the Company elects to make interest payments by check mailed to the Holders at their address
set forth in the register of Holders. 
 3. Paying Agent and Registrar. Initially, Wells Fargo Bank, National Association
(the “Trustee”) will act as a Paying Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to the Holders. The Company or any of its Subsidiaries may act as Paying Agent or Registrar. 

4. Indenture. This Note is one of the series designated on the face hereof. This Note is one of a duly authorized issue of
securities of the Company issued and to be issued in one or more series under an Indenture dated as of January 3, 2007 (the “Base Indenture”), between the Company and the Trustee, as supplemented by the Sixth Supplemental
Indenture, dated as of March 13, 2012, between the Company and the Trustee (the “Sixth Supplemental Indenture” and, together with the Base Indenture, as supplemented by the Sixth Supplemental Indenture, the
“Indenture”). This is one of an issue of Notes of the Company issued, or to be issued, under the Indenture. The terms of the Notes include those stated in the Indenture and those made part of the Indenture by reference to the Trust
Indenture Act of 1939 (15 U.S. 

  
 A-1-5

 
Code §§ 77aaa-77bbbb), as amended from time to time (the “Trust Indenture Act”). The Notes are subject to all such terms, and Holders are referred to the Indenture
and the Trust Indenture Act for a statement of them. Capitalized and certain other terms used herein and not otherwise defined have the meanings set forth in the Indenture. 
 5. Optional Redemption. The Notes of this series are subject to redemption at any time or from time to time, in whole or in part, at the Company’s option at a Redemption Price equal to the
greater of (i) 100% of the principal amount of the Notes to be redeemed, and (ii) as determined by the Quotation Agent, the sum of the present values of the remaining scheduled payments of principal and interest in respect of the Notes to
be redeemed (not including any portion of those payments of interest accrued as of the date of redemption) discounted to the Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Adjusted Treasury
Rate plus 50 basis points, plus accrued interest to the Redemption Date. The Company may provide in such notice that payment of such price and performance of the Company’s obligations with respect to such redemption or purchase may be performed
by another Person. Any such notice may, at the Company’s discretion, be subject to the satisfaction of one or more conditions precedent. 
 Any notice to holders of Notes of a redemption pursuant to paragraph 5 hereof will include the appropriate calculation of the Redemption Price, but does not need to include the Redemption Price itself.
The actual Redemption Price, calculated as described above, will be set forth in an Officers’ Certificate of the Company delivered to the Trustee no later than two Business Days prior to the Redemption Date. 

6. Redemption Procedures. The Trustee will select Notes called for redemption in part pursuant to paragraph 5 on a pro rata
basis or on as nearly a pro rata basis as is practicable (subject to procedures of the Depository); provided that no Notes of $2,000 or less shall be redeemed in part. A new Note in principal amount equal to the unredeemed portion
thereof will be issued in the name of the Holder thereof upon cancellation of the original Note, or in the case of Notes represented by a Global Security, the outstanding principal amount of such Global Security will be reduced by book-entry. Notes
called for redemption pursuant to paragraph 5 hereto become due on the Redemption Date. On and after the Redemption Date, interest stops accruing on Notes or portions of them called for redemption (unless there is a default in the payment thereof).

 7. Notice of Redemption. Notices of redemption pursuant to paragraph 5 shall be mailed by first class mail at least 30
but not more than 60 days before the Redemption Date to each Holder of Notes to be redeemed at its registered address. If any Note is to be redeemed in part only, the notice of redemption that relates to such Note shall state the portion of the
principal amount thereof to be redeemed. 
 8. Change of Control. Upon the occurrence of a Change of Control Triggering
Event, unless all Notes have been called for redemption pursuant to paragraph 5 of this Note, each Holder of Notes of this series shall have the right to require the Company to repurchase all or any part (equal to $2,000 or an integral multiple of
$1,000 in excess thereof) of such Notes at an offer price in cash equal to the Change of Control Payment. The Change of Control Offer will be made in accordance with the terms specified in the Indenture. 

  
 A-1-6

 9. Denominations, Transfer, Exchange. The Notes are in registered form without
coupons in denominations of $2,000 and integral multiples of $1,000 in excess thereof. A Holder may transfer or exchange Notes in accordance with the Indenture. The Registrar may require a Holder, among other things, to furnish appropriate
endorsements and transfer documents and to pay to it any taxes and fees required by law or permitted by the Indenture. 
 10.
Persons Deemed Owners. The registered Holder of this Note may be treated as the owner of this Note for all purposes. 

11. Unclaimed Money. If money for the payment of principal or interest remains unclaimed for two years, the Trustee or Paying
Agent will pay the money back to the Company at its written request. After that, Holders entitled to the money must look to the Company for payment as general creditors unless an “abandoned property” law designates another Person.

 12. Amendment, Supplement, Waiver, Etc. The Company and the Trustee (if a party thereto) may, without the consent of
the Holders of any outstanding Notes, amend, waive or supplement the Indenture or the Notes for certain specified purposes, including, among other things, curing ambiguities, defects or inconsistencies, maintaining the qualification of the Indenture
under the Trust Indenture Act of 1939, as amended, providing for the assumption by a successor to the Company of its obligations under the Indenture and making any change that does not materially and adversely affect the rights of any Holder. Other
amendments and modifications of the Indenture or the Notes may be made by the Company and the Trustee with the consent of the Holders of not less than a majority of the aggregate principal amount of the outstanding Notes, subject to certain
exceptions requiring the consent of the Holders of the particular Notes to be affected. 
 13. Successor Corporation.
When a successor corporation assumes all the obligations of its predecessor under the Notes and the Indenture and the transaction complies with the terms of Article Five of the Base Indenture, the predecessor corporation will, except as provided in
Article Five of the Base Indenture, be released from those obligations. 
 14. Defaults and Remedies. Events of Default
are set forth in the Indenture. Subject to certain limitations in the Indenture, if an Event of Default (other than an Event of Default specified in Sections 6.01(4) and 6.01(5) of the Base Indenture) occurs and is continuing, then, and in each and
every such case, either the Trustee, by notice in writing to the Company, or the Holders of not less than 25% of the principal amount of the Notes then outstanding, by notice in writing to the Company and the Trustee, may, and the Trustee at the
request of such Holders shall, declare due and payable, if not already due and payable, the principal of and any accrued and unpaid interest on all of the Notes; and upon any such declaration all such amounts upon such Notes shall become and be
immediately due and payable, anything in the Indenture or in the Notes to the contrary notwithstanding. If an 

  
 A-1-7

 
Event of Default specified in Sections 6.01(4) and 6.01(5) of the Base Indenture occurs, then the principal of and any accrued and unpaid interest on all of the Notes shall immediately become due
and payable without any declaration or other act on the part of the Trustee or any Holder. Holders may not enforce the Indenture or the Notes except as provided in the Indenture. The Trustee may require indemnity satisfactory to it before it
enforces the Indenture or the Notes. Subject to certain limitations, Holders of a majority in principal amount of the then outstanding Notes may direct the Trustee in its exercise of any trust or power, provided, that the Trustee will be entitled to
refuse to follow any such direction that conflicts with law or the Indenture or that the Trustee determines in good faith is unduly prejudicial to the rights of other Holders or could, in reasonable likelihood, impose personal liability upon the
Trustee, unless the Trustee is offered indemnity satisfactory to it. The Trustee may withhold from Holders notice of any continuing default (except a default in payment of principal, premium, if any, or interest on the Notes or a default in the
observance or performance of any of the obligations of the Company under Article Five of the Base Indenture) if it determines that withholding notice is in their best interests. 

15. Trustee Dealings with Company. Subject to certain limitations imposed by the Trust Indenture Act, the Trustee, in its
individual or any other capacity, may make loans to, accept deposits from, and perform services for the Company or its Affiliates, and may otherwise deal with the Company or its Affiliates, as if it were not Trustee. 

16. No Recourse Against Others. No past, present or future director, officer, employee, incorporator, agent, member or stockholder
or Affiliate of the Company, as such, shall have any liability for any obligations of the Company under the Notes, the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Notes by
accepting a Note waives and releases all such liabilities. The waiver and release are part of the consideration for issuance of the Notes. 
 17. Discharge. The Company’s obligations pursuant to the Indenture will be discharged, except for obligations pursuant to certain sections thereof, subject to the terms of the Indenture, upon
the payment of all the Notes or upon the irrevocable deposit with the Trustee of United States dollars or Government Obligations sufficient to pay when due principal of and interest on the Notes to maturity or redemption. 

18. Authentication. This Note shall not be valid until the Trustee signs the certificate of authentication on the other side of
this Security. 
 19. Governing Law. THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE
STATE OF NEW YORK. The Trustee and the Company agree to submit to the jurisdiction of the courts of the State of New York in any action or proceeding arising out of or relating to the Indenture or the Notes. 

20. Abbreviations. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in
common), TENANT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

  
 A-1-8

 The Company will furnish to any Holder upon written request and without charge a copy of the
Indenture. Requests may be made to: 
 If to the Company: 

R.R. Donnelley & Sons Company 
 111 South Wacker Drive 
 Chicago, Illinois 60606 

	 	Attn:	General Counsel 

	 	Fax:	(312) 326-8594 

With a copy to: 
 Sullivan & Cromwell LLP 
 125 Broad Street 

New York, New York 10004 
 Attn: Robert W. Downes 

	 	Tel:	(212) 558-4000 

	 	Fax:	(212) 558-3588 

  
 A-1-9

 ASSIGNMENT 
 I or we assign and transfer this Note to: 
  

 
 (Insert assignee’s social
security or tax I.D. number) 
  
  

(Print or type name, address and zip code of assignee) 
 and irrevocably appoint: 
 Agent to transfer this Note on the books of the
Company. The Agent may substitute another to act for him. 
  

									
	Date: ________________________________	 		 	Your Signature:	 	 
		 		 		 		 	(Sign exactly as your name appears on the other side of this Note)

 Signature Guarantee: ______________________________ 

SIGNATURE GUARANTEE 
 Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation in the Security Transfer
Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as
amended. 

  
 A-1-10

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