Document:

Master Security Agreement

 EXHIBIT 10.12 
 MASTER SECURITY AGREEMENT 
 No. 4081054 
 Dated as of March 24, 2004 (“Agreement”) 
 THIS AGREEMENT is between Oxford Finance Corporation (together with its successors and assigns, if any, “Secured Party”) and Phenomix Corporation
(“Debtor”). Secured Party has an office at 133 N. Fairfax Street, Alexandria, VA 22314. Debtor is a corporation organized and existing under the laws of the state of Delaware. Debtor’s mailing address and chief place of
business is 5871 Oberlin Dr., Suite 200, San Diego, CA 92121. 
  

	1.	CREATION OF SECURITY INTEREST. 

 Debtor grants to
Secured Party, its successors and assigns, a security interest in and against all property listed on any collateral schedule now or in the future annexed to or made a part of this Agreement (“Collateral Schedule”), and in and
against all additions, attachments, accessories and accessions to such property, all substitutions, replacements or exchanges therefore, and all insurance and/or other proceeds thereof (all such property is individually and collectively called the
“Collateral”). This security interest is given to secure the payment and performance of all debts, obligations and liabilities of any kind whatsoever of Debtor to Secured Party, now existing or arising in the future under this
Agreement, including but not limited to the payment and performance of certain Promissory Notes from time to time identified on any Collateral Schedule (collectively “Notes” and each a “Note”), and any renewals,
extensions and modifications of such debts, obligations and liabilities (such Notes, debts, obligations and liabilities are called the “Indebtedness”). Debtor acknowledges that, notwithstanding that the Note(s) may be paid in full,
this Security Agreement shall continue to secure the payment and performance of all other debts, obligations and liabilities of any kind whatsoever of Debtor to Secured Party, now existing or arising in the future in connection with the
Indebtedness, and that Secured Party shall be under no obligation to release the Collateral unless and until all Indebtedness of Debtor to Secured Party has been paid and satisfied; provided, however, Secured Party, in its sole and exclusive
discretion, may elect to release some of the Collateral without prejudice to Secured Party’s security interest in the remaining Collateral. Unless otherwise provided by applicable law, notwithstanding anything to the contrary contained in this
Agreement, to the extent that Secured Party asserts a purchase money security interest in any items of Collateral (“PMSI Collateral”): (i) the PMSI Collateral shall secure only that portion of the Indebtedness which has been
advanced by Secured Party to enable Debtor to purchase, or acquire rights in or the use of such PMSI Collateral (the “PMSI Indebtedness”), and (ii) no other Collateral shall secure the PMSI Indebtedness. 
  

	2.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 

 Debtor represents, warrants and covenants as of the date of this Agreement and as of the date of each Collateral Schedule that: 
  

	 	(a)	Debtor’s exact legal name is as set forth in the preamble of this Agreement and Debtor is, and will remain, duly organized, existing and in good standing under the laws of the
State in the state in which it is organized, has its chief executive offices at the location specified in the preamble, and is, and will remain, duly qualified and licensed in every jurisdiction wherever necessary to carry on its business and
operations; 

  

	 	(b)	Debtor has adequate power and capacity to enter into, and to perform its obligations under this Agreement, each Note and any other documents evidencing, or given in connection with,
any of the Indebtedness (all of the foregoing are called the “Debt Documents”); 

  

	 	(c)	This Agreement and the other Debt Documents have been duly authorized, executed and delivered by Debtor and constitute legal, valid and binding agreements enforceable in accordance
with their terms, except to the extent that the enforcement of remedies may be limited under applicable bankruptcy and insolvency laws; 

  

	 	(d)	No approval, consent or withholding of objections is required from any governmental authority or instrumentality with respect to the entry into, or performance by Debtor of any of
the Debt Documents, except any already obtained; 

  

	 	(e)	The entry into, and performance by, Debtor of the Debt Documents will not (i) violate any of the organizational documents of Debtor or any judgment, order, law or regulation
applicable to Debtor, or (ii) result in any breach of or constitute a default under any contract to which Debtor is a party, or result in the creation of any lien, claim or encumbrance on any of Debtor’s property (except for liens in favor
of Secured Party) pursuant to any indenture, mortgage, deed of trust, bank loan, credit agreement, or other agreement or instrument to which Debtor is a party; 

  

	 	(f)	There are no suits or proceedings pending in court or before any commission, board or other administrative agency against or affecting Debtor which could, in the aggregate, have a
material adverse effect on Debtor, its business or operations, or its ability to perform its obligations under the Debt Documents, nor does Debtor have reason to believe that any such suits or proceedings are threatened; 

	 	(g)	All financial statements delivered to Secured Party in connection with the Indebtedness have been prepared in accordance with generally accepted accounting principles, and since the
date of the most recent financial statement, there has been no material adverse change in Debtor’s financial condition; 

  

	 	(h)	The Collateral is not, and will not be, used by Debtor for personal, family or household purposes; 

  

	 	(i)	The Collateral is, and will remain, in good condition and repair, normal wear and tear excepted, and Debtor will not be negligent in its care and use; 

  

	 	(j)	All of the tangible Collateral is located at the locations set forth on each Collateral Schedule. Debtor shall give the Secured Party 30 days prior written notice of any relocation
of any Collateral; 

  

	 	(k)	Debtor is, and will remain, the sole and lawful owner, and in possession of, the Collateral, and has the sole right and lawful authority to grant the security interest described in
this Agreement; 

  

	 	(l)	The Collateral is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever, except for (i) liens in favor of Secured Party, (ii) liens
for taxes not yet due or for taxes being contested in good faith and which do not involve, in the judgment of Secured Party, any risk of the sale, forfeiture or loss of any of the Collateral, and (iii) inchoate material men’s,
mechanic’s, repairmen’s and similar liens arising by operation of law in the normal course of business for amounts which are not delinquent (all of such liens are called “Permitted Liens”). 

  

	 	(m)	All federal, state and local tax returns required to be filed by Debtor have been filed with the appropriate governmental agencies and all taxes due and payable by Debtor have been
timely paid. Debtor will pay when due all taxes, assessments and other liabilities except as contested in good faith and by appropriate proceedings and for which adequate reserves have been established; 

  

	 	(n)	No event or condition exists under any material agreement, instrument or document to which Debtor is a party or may be subject, or by which Debtor or any of its properties are
bound, which constitutes a material default or an event of default thereunder, or will, with the giving of notice, passage of time, or both, would constitute a material default or event of default thereunder; 

  

	 	(o)	Upon the request of Secured Party any report, certificate, schedule, notice or financial information submitted by Debtor to the Secured Party pursuant to this Agreement shall be
certified as true and correct by the president, treasurer or chief financial officer of Debtor; 

  

	 	(p)	Debtor shall give the Secured Party prompt written notice of any event, occurrence or other matter which has resulted or could reasonably be expected to result in a material adverse
change in its financial condition, business operations, prospects, product development, technology, or business which would impair the ability of Debtor to perform its obligations hereunder or under any of the other material financing agreements to
which it is a party or of Secured Party to enforce the Indebtedness or realize upon the Collateral; and 

  

	 	(q)	Debtor has previously delivered to the Secured Party a certificate signed by the Debtor and entitled “Perfection Certificate” (the “Perfection
Certificate”). The Debtor represents and warrants to the Secured Party as follows: (a) the Debtor’s exact legal name is that indicated on the Perfection Certificate and on the signature page hereof, (b) the Debtor is an
organization of the type, and is organized in the jurisdiction set forth in the Perfection Certificate, (c) the Perfection Certificate accurately sets forth the Debtor’s organizational identification number or accurately states that the
Debtor has none, (d) the Perfection Certificate accurately sets forth the Debtor’s place of business or, if more than one, its chief executive office, as well as the Debtor’s mailing address, if different, and (e) all other
information set forth on the Perfection Certificate pertaining to the Debtor is accurate and complete. 

  

	3.	COLLATERAL. 

  

	 	(a)	Until the declaration of any default, Debtor shall remain in possession of the Collateral; except that Secured Party shall have the right to possess (i) any chattel paper or
instrument that constitutes a part of the Collateral, and (ii) any other Collateral in which Secured Party’s security interest may be perfected only by possession. Secured Party may inspect any of the Collateral during normal business
hours after giving Debtor reasonable prior notice. 

  

	 	(b)	Debtor shall (i) use the Collateral only in its trade or business, (ii) maintain all of the Collateral in good operating order and repair, normal wear and tear excepted,
(iii) use and maintain the Collateral in material compliance with manufacturers recommendations and all applicable laws, and (iv) keep all of the Collateral free and clear of all liens, claims and encumbrances (except for Permitted Liens).

	 	(c)	Secured Party does not authorize and Debtor agrees it shall not (i) part with possession of any of the Collateral (except to Secured Party or for maintenance and repair),
(ii) remove any of the Collateral from the continental United States, or (iii) sell, rent, lease, mortgage, license, grant a security interest in or otherwise transfer or encumber (except for Permitted Liens) any of the Collateral.

  

	 	(d)	Debtor shall pay promptly when due all taxes, license fees, assessments and public and private charges levied or assessed on any of the Collateral, on its use, or on this Agreement
or any of the other Debt Documents. At its option, Secured Party may discharge taxes, liens, security interests or other encumbrances at any time levied or placed on the Collateral and may pay for the maintenance, insurance and preservation of the
Collateral and effect compliance with the terms of this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on demand, all costs and expenses incurred by Secured Party in connection with such payment or
performance and agrees that such reimbursement obligation shall constitute Indebtedness. 

  

	 	(e)	Debtor shall, at all times, keep accurate and complete records of the Collateral, and Secured Party shall have the right to inspect and make copies of all of Debtor’s books and
records relating to the Collateral during normal business hours, after giving Debtor reasonable prior notice. 

  

	 	(f)	Debtor agrees and acknowledges that any third person who may at any time possess all or any portion of the Collateral shall be deemed to hold, and shall hold, the Collateral as the
agent of, and as pledge holder for, Secured Party. Secured Party may at any time give notice to any third person described in the preceding sentence that such third person is holding the Collateral as the agent of, and as pledge holder for, the
Secured Party. 

  

	4.	INSURANCE. 

  

	 	(a)	Debtor shall at all times bear the entire risk of any loss, theft, damage to, or destruction of, any of the Collateral from any cause whatsoever except to the extent any such loss,
theft, damage or destruction results from or arises out of the gross negligence or willful misconduct of Secured Party. 

  

	 	(b)	Debtor agrees to keep the Collateral insured against loss or damage by fire and extended coverage perils, theft, burglary, and for any or all Collateral, which are vehicles, for
risk of loss by collision, and if requested by Secured Party, against such other risks as Secured Party may reasonably require. The insurance coverage shall be in an amount no less than the full replacement value of the Collateral, and deductible
amounts, insurers and policies shall be reasonably acceptable to Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance evidencing such coverage. Each policy shall name Secured Party as a loss payee, shall provide
for coverage to Secured Party regardless of the breach by Debtor of any warranty or representation made therein, shall not be subject to co-insurance, and shall provide that coverage may not be canceled or altered by the insurer except upon thirty
(30) days prior written notice to Secured Party. Upon the occurrence and during the continuation of an event of default, Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance and adjustments with
insurers, and to receive payment of and execute or endorse all documents, checks or drafts in connection with insurance payments. Proceeds of insurance shall be applied, at the option of Secured Party, to repair or replace the Collateral or to
reduce any of the Indebtedness. 

  

	5.	REPORTS. 

  

	 	(a)	Debtor shall promptly notify Secured Party of (i) any change in the name of Debtor, (ii) any change in the state of its incorporation or registration, (iii) any
relocation of its chief executive offices, (iv) any of the Collateral being lost, stolen, missing, destroyed, materially damaged or worn out, or (v) any lien, claim or encumbrance other than Permitted Liens attaching to or being made
against any of the Collateral. 

  

	 	(b)	Debtor will deliver to Secured Party within one hundred fifty (150) days of the close of each fiscal year of Debtor, Debtor’s complete financial statements including a
balance sheet, income statement, statement of shareholders’ equity and statement of cash flows, each prepared in accordance with generally accepted accounting principles consistently applied, certified by a recognized firm of certified public
accountants reasonably satisfactory to Secured Party. Debtor will deliver to Secured Party copies of Debtor’s quarterly financial statements including a balance sheet, income statement and statement of cash flows, each prepared by Debtor in
accordance with generally accepted accounting principles consistently applied by Debtor and certified by Debtor’s president, treasurer or chief financial officer, within ninety (90) days after the close of each of the first three fiscal
quarters of Debtor. Debtor will deliver to Secured Party copies of all Forms 10-K and 10-Q, if any, within 30 days after the dates on which they are filed with the Securities and Exchange Commission. Debtor will deliver to Secured Party copies of
Debtor’s monthly financial statements including a balance sheet, income statement and statement of cashflows, each prepared by Debtor in accordance with generally accepted accounting principles consistently applied by Debtor and certified by
Debtor’s president, treasurer or chief financial officer, within forty-five (45) days after the close of each month except March, June, September and December. Debtor will deliver to Secured Party promptly upon request of Secured Party, in
form reasonably satisfactory to Secured Party, such other and additional information as Secured Party may reasonably request from time to time. 

	6.	FURTHER ASSURANCES. 

  

	 	(a)	Debtor shall, upon request of Secured Party, furnish to Secured Party such further information, execute and deliver to Secured Party such documents and instruments (including,
without limitation, Uniform Commercial Code financing statements) and shall do such other acts and things as Secured Party may at any time reasonably request relating to the perfection or protection of the security interest created by this Agreement
or for the purpose of carrying out the intent of this Agreement. Without limiting the foregoing, Debtor shall cooperate and do all acts deemed necessary or advisable by Secured Party to continue in Secured Party a perfected first security interest
in the Collateral, and shall obtain and furnish to Secured Party any subordinations, releases, landlord waivers, lessor waivers, mortgagee waivers, or control agreements, and similar documents as may be from time to time requested by, and in form
and substance reasonably satisfactory to, Secured Party. 

  

	 	(b)	Debtor shall perform any and all acts reasonably requested by the Secured Party to establish, maintain and continue the Secured Party’s security interest and liens in the
Collateral, including but not limited to, executing or authenticating financing statements and such other instruments and documents when and as reasonably requested by the Secured Party. Debtor hereby authorizes Secured Party through any of Secured
Party’s employees, agents or attorneys to file any and all financing statements, including, without limitation, any original filings, continuations, transfers or amendments thereof required to perfect Secured Party’s security interest and
liens in the Collateral under the UCC without authentication or execution by Debtor. Debtor hereby irrevocably authorizes the Secured Party at any time and from time to time to file in any filing office in any Uniform Commercial Code jurisdiction
any initial financing statement(s) and amendments thereto that (a) indicate the Collateral (i) is subject to the Secured Party’s security interest, regardless of whether any particular asset comprised in the Collateral falls within
the scope of Article 9 of the Uniform Commercial Code of the State or such jurisdiction, or (ii) as being of an equal or lesser scope or with greater detail, and (b) provide any other information required by part 5 of Article 9 of the
Uniform Commercial Code of the State or such other jurisdiction for the sufficiency or filing office acceptance of any financing statement or amendment, including (i) whether the Debtor is an organization, the type of organization and any
organization identification number issued to the Debtor, and (ii) in the case of a financing statement filed as a fixture filing, a sufficient description of real property to which the Collateral relates. The Debtor agrees to furnish any such
information to the Secured Party promptly upon the Secured Party’s request. 

  

	 	(c)	Debtor shall indemnify and defend the Secured Party, its successors and assigns, and their respective directors, officers and employees, from and against all claims, actions and
suits (including, without limitation, related attorneys’ fees) of any kind whatsoever arising, directly or indirectly, in connection with any of the Collateral other than any claims, actions and suits (including, without limitation, related
attorneys’ fees) arising in connection with Secured Party’s gross negligence or willful misconduct. 

  

	7.	DEFAULT AND REMEDIES. 

  

	 	(a)	Debtor shall be in default under this Agreement and each of the other Debt Documents if: 

  

	 	(i)	Debtor breaches its obligation to pay within two (2) business days after the date due any installment or other amount due or coming due under any of the Debt Documents or with
respect to any other obligations, within ten (10) business days after receipt of written notice from Secured Party that such payment is due. 

  

	 	(ii)	Debtor, without the prior written consent of Secured Party, attempts to or does sell, rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or encumber
(except for Permitted Liens) any of the Collateral; 

  

	 	(iii)	Debtor materially breaches any of its insurance obligations under Section 4; 

  

	 	(iv)	Debtor materially breaches any of its other non-payment obligations under any of the Debt Documents and fails to cure that breach within thirty (30) days after written notice
from Secured Party; 

  

	 	(v)	Any warranty, representation or statement made by Debtor in any of the Debt Documents or otherwise in connection with any of the Indebtedness shall be false or misleading in any
material respect; 

  

	 	(vi)	Any of the Collateral is subjected to attachment, execution, levy, seizure or confiscation in any legal proceeding or otherwise, or if any legal or administrative proceeding is
commenced against Debtor or any of the Collateral, which in the good faith judgment of Secured Party subjects any of the Collateral to a material risk of attachment, execution, levy, seizure or confiscation and no bond is posted or protective order
obtained to negate such risk; 

  

	 	(vii)	Debtor breaches or is in default under any other material agreement between Debtor and Secured Party and fails to cure that breach within fifteen (15) days after written notice
from Secured Party; 

	 	(viii)	Debtor or any guarantor or other obligor for any of the Indebtedness (collectively “Guarantor”) dissolves, terminates its existence, becomes insolvent or ceases to
do business as a going concern; 

  

	 	(ix)	If Debtor or any Guarantor is a natural person, Debtor or any such Guarantor dies or becomes incompetent; 

  

	 	(x)	A receiver is appointed for all or of any part of the property of Debtor or any Guarantor, or Debtor or any Guarantor makes any assignment for the benefit of creditors;

  

	 	(xi)	Debtor or any Guarantor files a petition under any bankruptcy, insolvency or similar law, or any such petition is filed against Debtor or any Guarantor and is not dismissed within
forty-five (45) days; 

  

	 	(xii)	Debtor’s improper filing of an amendment or termination statement relating to a filed financing statement describing the Collateral. 

  

	 	(xiii)	Debtor shall merge with or consolidate into any other entity or sell all or substantially all of its assets or in any manner terminate its existence without Secured Party’s
written consent which will not be unreasonably withheld; 

  

	 	(xiv)	If Debtor is a privately held corporation, more than 50% of Debtor’s voting capital stock, or effective control of Debtor’s voting capital stock, issued and outstanding
from time to time, is not retained by the holders of such stock on the date the Agreement is executed (other than by the sale by Debtor of Debtor’s equity securities in a public offering or to venture capital investors, strategic investors,
other institutional investors or high net worth individuals so long as Debtor identifies to the Secured Party the investors prior to the closing of the investment); 

  

	 	(xv)	If Debtor is a publicly held corporation, there shall be a change in the ownership of Debtor’s stock such that Debtor is no longer subject to the reporting requirements of the
Securities Exchange Act of 1934 or no longer has a class of equity securities registered under Section 12 of the Securities Act of 1933 without the written consent of Secured Party, which will not be unreasonably withheld;

  

	 	(xvi)	Debtor defaults under any other material financing arrangement between Debtor and a third party; and 

  

	 	(xvii)	There has been a material adverse change in the financial condition, business, operations, prospects, product development, technology, or business of Debtor from the date hereof, or
a change or event shall have occurred which would impair the ability of Debtor to perform its obligations hereunder or under any of the other Debt Documents or of Secured Party to enforce the Indebtedness or realize upon the Collateral;

  

	 	(b)	If Debtor is in default, the Secured Party, at its option, may declare any or all of the Indebtedness to be immediately due and payable, without demand or notice to Debtor or any
Guarantor. The accelerated obligations and liabilities shall bear interest (both before and after any judgment) until paid in full at the lower of eighteen percent (18%) per annum or the maximum rate not prohibited by applicable law.

  

	 	(c)	Secured Party shall have all of the rights and remedies of a Secured Party under the Uniform Commercial Code, and under any other applicable law. Without limiting the foregoing,
Secured Party shall have the right to (i) notify any account debtor of Debtor or any obligor on any instrument which constitutes part of the Collateral to make payment to the Secured Party, (ii) with or without legal process, enter any
premises where the Collateral is located and take possession of and remove the Collateral from the premises or store it on the premises, (iii) sell the Collateral at public or private sale, in whole or in part, and have the right to bid and
purchase at said sale, or (iv) lease or otherwise dispose of all or part of the Collateral, applying proceeds from such disposition to the obligations then in default. If requested by Secured Party, Debtor shall promptly assemble the Collateral
and make it available to Secured Party at a place to be designated by Secured Party, which is reasonably convenient to both parties. Secured Party may also render any or all of the Collateral unusable at the Debtor’s premises and may dispose of
such Collateral on such premises without liability for rent or costs. Any notice that Secured Party is required to give to Debtor under the Uniform Commercial Code of the time and place of any public sale or the time after which any private sale or
other intended disposition of the Collateral is to be made shall be deemed to constitute reasonable notice if such notice is given to the last known address of Debtor at least five (5) days prior to such action. Upon the occurrence and during
the continuation of an event of default, Debtor hereby appoints Secured Party as Debtor’s attorney-in-fact, with full authority in Debtor’s place and stead and in Debtor’s name or otherwise, from time to time in Secured Party’s
sole and arbitrary discretion, to take any action with respect to the Collateral and to execute any instrument which Secured Party may deem necessary or advisable to accomplish the purpose of this Agreement. 

  

	 	(d)	Proceeds from any sale or lease or other disposition shall be applied: first, to all costs of repossession, storage, and disposition including without limitation reasonable
attorneys’, appraisers’, and auctioneers’ fees; second, to discharge the obligations then in default; third, to discharge any other Indebtedness of Debtor to Secured Party, whether as obligor, endorser, guarantor, surety or
indemnitor; fourth, to expenses incurred in paying or settling liens and claims against the Collateral; and lastly, to Debtor, if there exists any surplus. Debtor shall remain fully liable for any deficiency. 

	 	(e)	In the event of default that is not cured with in thirty (30) days, Debtor agrees to pay all reasonable attorneys’ fees and other costs incurred by Secured Party in
connection with the enforcement, assertion, defense or preservation of Secured Party’s rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be permitted. Debtor further agrees that such fees and costs shall
constitute Indebtedness. 

  

	 	(f)	Secured Party’s rights and remedies under this Agreement or otherwise arising are cumulative and may be exercised singularly or concurrently. Neither the failure nor any delay
on the part of the Secured Party to exercise any right, power or privilege under this Agreement shall operate as a waiver, nor shall any single or partial exercise of any right, power or privilege preclude any other or further exercise of that or
any other right, power or privilege. SECURED PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND SIGNED BY
SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or waiver of any right or remedy on any future occasion. 

  

	 	(g)	DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY OF THE OTHER DEBT
DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN DEBTOR AND
SECURED PARTY. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY
TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT MAY BE FILED AS A
WRITTEN CONSENT TO A TRIAL BY THE COURT. 

  

	8.	MISCELLANEOUS. 

  

	 	(a)	This Agreement, any Note and/or any of the other Debt Documents may be assigned, in whole or in part, by Secured Party without notice to Debtor, and Debtor agrees not to assert
against any such assignee, or assignee’s assigns, any defense, set-off, recoupment claim or counterclaim which Debtor has or may at any time have against Secured Party for any reason whatsoever. Debtor agrees that if Debtor receives
written notice of an assignment from Secured Party, Debtor will pay amounts payable under any assigned Debt Documents to such assignee or as instructed by Secured Party. Debtor also agrees to confirm in writing receipt of the notice of assignment as
may be reasonably requested by Secured Party or assignee. 

  

	 	(b)	All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective addresses set forth in this Agreement (unless
and until a different address may be specified in a written notice to the other party), and shall be deemed given (i) on the date of receipt if delivered in hand or by confirmed facsimile transmission, (ii) on the next business day after
being sent by express mail, and (iii) on the fourth business day after being sent by regular, registered or certified mail. As used herein, the term “business day” shall mean and include any day other than Saturdays, Sundays, or other
days on which commercial banks in New York, New York are required or authorized to be closed. 

  

	 	(c)	Secured Party may correct patent errors and fill in all blanks in this Agreement or in any Collateral Schedule consistent with the agreement of the parties.

  

	 	(d)	Time is of the essence of this Agreement. This Agreement shall be binding upon each party and their respective heirs, executors, representatives, successors and assigns, and shall
inure to the benefit of each party, and their respective successors and assigns. 

  

	 	(e)	This Agreement and its Collateral Schedules constitute the entire agreement between the parties with respect to the subject matter of this Agreement and supersede all prior
understandings (whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND ITS COLLATERAL SCHEDULES SHALL NOT BE AMENDED ORALLY OR BY COURSE OF CONDUCT, BUT ONLY BY A WRITING SIGNED BY BOTH PARTIES. Section headings
contained in this Agreement have been included for convenience only, and shall not affect the construction or interpretation of this Agreement. 

	 	(f)	This Agreement shall continue in full force and effect until all of the Indebtedness has been indefeasibly paid in full to Secured Party or its assignee. The surrender, upon payment
or otherwise, of any Note or any of the other documents evidencing any of the Indebtedness shall not affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then exist or as it may be reasonably contemplated
will exist in the future. This Agreement shall automatically be reinstated if Secured Party is ever required to return or restore the payment of all or any portion of the Indebtedness (all as though such payment had never been made).

  

	 	(g)	DEBTOR AGREES THAT SECURED PARTY AND/OR ITS SUCCESSORS AND ASSIGNS SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS AGREEMENT SHALL BE GOVERNED AND CONSTRUED: (A) THE LAWS OF THE
COMMONWEALTH OF VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE LIABILITIES, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT SECURED PARTY’S OPTION. THIS CHOICE OF STATE LAWS IS EXCLUSIVE TO THE SECURED
PARTY. DEBTOR SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS AGREEMENT SHALL BE GOVERNED. DEBTOR ACKNOWLEDGES THAT THIS AGREEMENT IS BEING SIGNED BY THE SECURED PARTY IN PARTIAL CONSIDERATION OF SECURED PARTY’S RIGHT TO ENFORCE IN
THE JURISDICTION STATED ABOVE. DEBTOR CONSENTS TO JURISDICTION IN THE COMMONWEALTH OF VIRGINIA OR THE STATE IN WHICH ANY COLLATERAL IS LOCATED AND VENUE IN ANY FEDERAL OR STATE COURT IN THE COMMONWEALTH OF VIRGINIA OR THE STATE IN WHICH COLLATERAL
IS LOCATED FOR SUCH PURPOSES AND WAIVES ANY AND ALL RIGHTS TO CONTEST SAID JURISDICTION AND VENUE AND ANY OBJECTION THAT SAID COUNTY IS NOT CONVENIENT. DEBTOR WAIVES ANY RIGHTS TO COMMENCE ANY ACTION AGAINST SECURED PARTY IN ANY JURISDICTION EXCEPT
VIRGINIA, OR IF SECURED PARTY CHOOSES TO LITIGATE IN A STATE WHERE COLLATERAL IS LOCATED THEN IN SUCH COUNTY AND STATE. 

 IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have duly executed this Agreement in one or more counterparts, each of which shall be deemed to be an original, as of the day and year first
aforesaid. 
  

									
	SECURED PARTY:	 		 	DEBTOR:
			
	Oxford Finance Corporation	 		 	Phenomix Corporation
					
	By:	 	/s/ Michael J. Altenburger	 		 	By:	 	/s/ Laura Shawver
	Name:	 	Michael J. Altenburger	 		 	Name:	 	Laura Shawver
	Title:	 	Chief Financial Officer	 		 	Title:	 	President and CEOLoan and Security Agreement

 EXECUTION COPY 
 EXHIBIT 10.13 
 LOAN AND SECURITY AGREEMENT 
 This LOAN AND SECURITY AGREEMENT, dated as of November 22, 2006 (this “Loan Agreement”), is
entered by and between PHENOMIX CORPORATION, a Delaware corporation (“Borrower”); and PINNACLE VENTURES, L.L.C. as agent (“Agent”) for the lenders identified on Schedule 1
hereto (such lenders, together with their respective successors and assigns are referred to hereinafter each individually as a “Lender” and collectively as the “Lenders”), and the Lenders. Capitalized
terms used and not otherwise defined in this Loan Agreement shall have the respective meanings given to such terms in Article 10. 
 In
consideration of the covenants, conditions and agreements set forth herein and intending to be legally bound, the parties agree as follows: 
 Article 1.
THE LOANS. 
 Section 1.01 Commitment. Subject to the terms and conditions of this Loan Agreement, Lenders agree to advance to
Borrower (the “Advances”) from time to time on or prior to June 30, 2007 (the “Funding Termination Date”), one or more term loans in an aggregate principal amount of up to Eight Million Dollars
($8,000,000). Advances shall be made not more often than monthly in amounts of no less than Five Hundred Thousand Dollars ($500,000) provided that if there is less than Five Hundred Thousand Dollars available to be borrowed under this
Section 1.01, then such Advance shall not be less than the available principal amount to be borrowed. Borrower may prepay Advances in accordance with Section 1.02(d). 
 Section 1.02 Interest and Payments. 
  

	 	(a)	Interest. Borrower shall pay interest in advance on the unpaid principal amount of each Advance from the date of such Advance until such Advance is paid in full, at a per
annum rate of interest equal to the Prime Rate determined as of the date of such Advance plus two hundred (200) basis points, based upon a year of 360 days and actual days elapsed. If Borrower pays interest on such Advance which is determined
to be in excess of the then legal maximum rate, then that portion of each interest payment representing an amount in excess of the then legal maximum rate shall be deemed a payment of principal and applied against the principal of the Advance.

  

	 	(b)	Payments of Principal and Interest. For each Advance, Borrower shall make six (6) equal monthly payments of interest only (payable in advance) on the first Business Day
of each month after the Funding Date (or, if the Funding Date occurs on the first Business Day of a month, on such Funding Date) (each a “Payment Date”). Thereafter, Borrower shall make thirty (30) equal payments of
principal and interest (payable in advance) on the first Business Day of each month (each a “Payment Date”) until the Advance is paid in full. The amount of each such payment shall be sufficient to fully amortize the
principal and interest due on the applicable Advance over such thirty (30) month period. 

  

	 	(c)	Interim Interest Payment. For each Advance, unless the Funding Date is a Payment Date, Borrower shall make an advance payment of interest at the otherwise applicable rate
referred to in Section 1.02(a) on the Funding Date for the period from the Funding Date to the first Payment Date. 

  

	 	(d)	 Prepayment. Upon five (5) Business Days’ prior written notice to Agent, Borrower may, at its option, at any time, prepay all and not less than all
of the Advances, in an amount equal to the outstanding principal amounts of the Advances, plus accrued and unpaid interest thereon through and including the date of such prepayment, plus any other amounts then due to Lenders provided, that if any
Advance is prepaid (i) within 1 year of funding the Advance, there will be a 2% premium on the 

	 	 
outstanding principal amount payable in conjunction with the prepayment, (ii) between 1 and 2 years of funding the Advance, there will be a 1% premium
on the outstanding principal amount payable in conjunction with the prepayment, and (iii) after 2 years of funding the Advance, there will be no premium on the outstanding principal amount payable in conjunction with the prepayment.

 Section 1.03 Use of Proceeds; the Advances and the Notes; Disbursement. 
  

	 	(a)	Use of Proceeds. The proceeds of the Advances shall be used for general corporate purposes. 

  

	 	(b)	The Advances and the Notes. The obligation of Borrower to repay the aggregate unpaid principal amount of and interest on each Advance shall be evidenced by a Note setting
forth the principal amount of such Advance and the payments due. Agent shall keep a record of the payments made under each Note on its books which records shall be prima facie evidence of the amounts paid under the Notes absent manifest error. Any
failure by Agent to obtain or retain such a Note shall not limit or otherwise affect the obligations of Borrower to pay amounts due hereunder with respect to an Advance. 

  

	 	(c)	Notice and Disbursement. Whenever Borrower desires Lenders to make an Advance, Borrower shall notify Agent in writing at least ten (10) Business Days in
advance of the desired Funding Date, which notice shall be irrevocable. Lenders’ obligation to make Advances shall be subject to the satisfaction of the conditions set forth in Section 3.01(b). Lenders shall have the right to
request that Borrower furnish Lenders with such additional information with respect to the Advance as Lenders shall reasonably request. Subject to the satisfaction of the conditions set forth in this Loan Agreement, each
Lender shall disburse its pro rata portion of each Advance to the account of Borrower as specified in Section 9.06. 

 Section 1.04
Other Payment Terms. 
  

	 	(a)	Place and Manner. All regularly scheduled payments due to the Lenders shall be effected by automatic debit of the appropriate funds from Borrower’s Primary Operating
Account. Borrower shall make all other payments due to the Lenders in lawful money of the United States, in immediately available funds, at the address for payments specified in Section 9.06. 

  

	 	(b)	Date. Whenever any payment due hereunder shall fall due on a day other than a Business Day, such payment shall be made on the next succeeding Business Day, and such extension
of time shall be included in the computation of interest or fees, as the case may be. 

  

	 	(c)	Default Rate. If any amounts required to be paid by Borrower under this Loan Agreement or the other Transaction Documents (including principal or interest payable on the
Advance, any fees or other amounts) remain unpaid after such amounts are due, Borrower shall pay interest on the aggregate, outstanding principal balance hereunder from the date due until such past due amounts are paid in full, at a per annum rate
equal to the Default Rate. All computations of such interest shall be based on a year of 360 days and actual days elapsed. 

  

	 	(d)	Commitment Fee. Agent has received a commitment fee from Borrower in the amount of $15,000 (the “Commitment Fee”). The Commitment Fee is fully earned
and will be retained by Agent. 

  

	 	(e)	Legal Costs. Borrower shall reimburse Lender for Lender’s reasonable legal costs and expenses incurred in preparing and negotiating the Transaction Documents.

 Article 2. CREATION OF SECURITY INTEREST. 
 Section 2.01 Grant of Security Interest. Borrower grants and pledges to Agent on behalf of all Lenders a continuing security interest in all presently existing and hereafter acquired or arising Collateral in order to

  

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secure prompt payment of any and all Obligations and in order to secure prompt performance by Borrower of each of its covenants and duties under the
Transaction Documents. Such security interest constitutes a valid, first priority security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in Collateral acquired after the date hereof.
Notwithstanding termination of this Loan Agreement, Agent’s Lien on the Collateral shall remain in effect for so long as any Obligations are outstanding. 
 Section 2.02 Liabilities Unconditional. Borrower is and shall remain absolutely and unconditionally liable for the performance of its obligations under the Transaction Documents, including without limitation any
deficiency by reason of the failure of the Collateral to satisfy all amounts due to Agent or the Lenders under any Transaction Document. 
 Article 3.
CLOSING. 
 Section 3.01 Conditions Precedent. The obligation of Lenders to fund an Advance shall be subject to the following
conditions precedent: 
  

	 	(a)	Conditions to Closing. Agent shall have received in connection with the Closing in form and substance satisfactory to Agent: 

  

	 	(i)	This Loan Agreement, duly executed by Borrower; 

  

	 	(ii)	Copies, certified by the Secretary or Assistant Secretary of Borrower, of: (A) the Certificate of Incorporation and Bylaws of Borrower (as amended to the date of this Loan
Agreement), (B) the resolutions adopted by Borrower’s board of directors authorizing the transaction and the documents being executed in connection therewith, and (C) the incumbency of the officers executing this Loan Agreement and
the other Transaction Documents on behalf of Borrower. 

  

	 	(iii)	Good Standing Certificate(s) (including tax status if available) with respect to Borrower from Borrower’s state of incorporation and principal place of business, if different,
(each) as of a date acceptable to Agent. 

  

	 	(iv)	Evidence of the insurance coverage required by Section 5.06 of this Loan Agreement. 

  

	 	(v)	All necessary consents of shareholders and other third parties with respect to the subject matter of the Loan Agreement and the other documents being executed in connection
therewith. 

  

	 	(vi)	A Warrant Purchase Agreement in the form provided by Agent and agreed to by Borrower, duly executed by Borrower. 

  

	 	(vii)	The Warrants to be issued to the designees of the Lenders in forms provided by Agent and agreed to by Borrower, duly executed by Borrower. 

  

	 	(viii)	A Management Rights Agreement in the form provided by Agent and agreed to by Borrower, duly executed by Borrower. 

  

	 	(ix)	Agreements sufficient to perfect a security interest in Borrower’s deposit accounts and securities accounts executed by each applicable bank or other financial institution, in
forms reasonably acceptable to Agent. 

  

	 	(x)	All other documents as Agent shall have reasonably requested. 

  

	 	(xi)	A legal opinion of counsel to Borrower in form and substance reasonably satisfactory to Agent. 

  

	 	(xii)	A payoff letter with respect to the Indebtedness to Comerica Bank under the December 23, 2004 Loan and Security Agreement. 

  

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	 	(b)	Conditions to Funding of Each Advance. Prior to the funding of each Advance, the following conditions with respect to such Advance shall have been satisfied by Borrower or
waived by Agent: 

  

	 	(i)	Borrower shall have executed and delivered a Note in the form of Exhibit A prepared by Agent setting forth the terms of the Advance. 

  

	 	(ii)	No Event of Default or Default shall have occurred and be continuing. 

  

	 	(iii)	In Agent’s sole discretion, no event or condition shall exist that has had or could be reasonably expected to have a Material Adverse Effect. 

  

	 	(iv)	The representations and warranties contained in this Loan Agreement and the other Transaction Documents to which Borrower is a party shall be true and correct in all material
respects as if made on the date of funding of the Advance and the items listed on any schedule shall be reasonably acceptable to Agent, except to the extent such representations and warranties expressly refer to an earlier date, in which case they
shall be true and correct in all material respects as of such earlier date. 

  

	 	(v)	Each of the Transaction Documents shall be in full force and effect. 

  

	 	(vi)	Borrower shall have provided to Agent such documents, instruments and agreements, including financing statements or amendments to financing statements, as Agent shall reasonably
request to evidence the perfection and priority of the security interests granted to Agent. 

 Article 4. REPRESENTATIONS AND WARRANTIES OF
BORROWER. 
 Borrower represents and warrants to Agent that: 
 Section 4.01 Due Incorporation, Qualification, etc. Each of Borrower and its Subsidiaries (i) is a corporation duly organized, validly existing and in good standing under the laws of its state of incorporation;
(ii) has the power and authority to own, lease and operate its properties and carry on its business as now conducted; and (iii) is duly qualified, licensed to do business and in good standing as a foreign corporation in each jurisdiction
where the failure to be so qualified or licensed could reasonably be expected to have a Material Adverse Effect. 
 Section 4.02
Authority. The execution, delivery and performance by Borrower of each Transaction Document to be executed by Borrower and the consummation of the transactions contemplated thereby (i) are within the power of Borrower and
(ii) have been duly authorized by all necessary actions on the part of Borrower. 
 Section 4.03 Enforceability. Each Transaction
Document executed, or to be executed, by Borrower has been, or will be, duly executed and delivered by Borrower and constitutes, or will constitute, a legal, valid and binding obligation of Borrower, enforceable against Borrower in accordance with
its terms, except as limited by bankruptcy, insolvency or other similar laws of general application relating to or affecting the enforcement of creditors’ rights generally and general principles of equity. 
 Section 4.04 Non-Contravention. The execution and delivery by Borrower of the Transaction Documents executed by Borrower and the performance and
consummation of the transactions contemplated thereby do not and will not (i) violate any Requirement of Law applicable to Borrower; (ii) violate any provision of, or result in the breach or the acceleration of, or entitle any other Person
to accelerate (whether after the giving of notice or lapse of time or both), any material Contractual Obligation of Borrower; or (iii) result in the creation or imposition of any Lien upon any property, asset or revenue of Borrower (except such
Liens as may be created in favor of Agent pursuant to this Loan Agreement or the other Transaction Documents). 
  

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 Section 4.05 Approvals. No consent, approval, order or authorization of, or registration,
declaration or filing with, any Governmental Authority or other Person (including, without limitation, the shareholders of any Person) is required in connection with the execution and delivery of the Transaction Documents executed by Borrower and
the performance and consummation of the transactions contemplated thereby. 
 Section 4.06 No Violation or Default. None of Borrower or
Borrower’s Subsidiaries is in violation of or in default with respect to (i) any Requirement of Law; or (ii) any Contractual Obligation (nor is there any waiver in effect which, if not in effect, would result in such a violation or
default), where, in each case, such violation or default, individually, or together with all such violations or defaults, could reasonably be expected to have a Material Adverse Effect. Without limiting the generality of the foregoing, neither
Borrower nor Borrower’s Subsidiaries (A) has violated any Environmental Laws, (B) has any liability under any Environmental Laws or (C) has received notice or other communication of an investigation or is under investigation by
any Governmental Authority having authority to enforce Environmental Laws, where such violation, liability or investigation could reasonably be expected to have a Material Adverse Effect. No Event of Default or Default has occurred and is
continuing. 
 Section 4.07 Litigation. No actions (including, without limitation, derivative actions), suits, proceedings or
investigations are pending or, to the knowledge of Borrower, threatened against Borrower or Borrower’s Subsidiaries at law or in equity in any court or before any other Governmental Authority which if adversely determined (i) could
reasonably be expected (alone or in the aggregate) to have a Material Adverse Effect or (ii) seeks to enjoin, either directly or indirectly, the execution, delivery or performance by Borrower of the Transaction Documents or the transactions
contemplated thereby. 
 Section 4.08 Title. Borrower has good and marketable title to all Collateral, free and clear of all Liens,
other than Permitted Liens. Borrower has no other deposit accounts or securities accounts, other than the deposit accounts and securities accounts described in Schedule 2. Except as described in Schedule 2, the Collateral is not in the
possession of any third party bailee (such as at a warehouse). All Inventory is in all material respects of good and marketable quality, free from material defects. 
 Section 4.09 Financial Statements. The Financial Statements of Borrower which have been delivered to Agent (i) are in accordance with the books and records of Borrower and its Subsidiaries,
which have been maintained in accordance with good business practice; (ii) have been prepared in conformity with generally accepted accounting principles; and (iii) fairly present in all material respects the consolidated financial
position of Borrower as of the dates presented therein and the results of operations, changes in financial positions or cash flows, as the case may be, for the periods presented therein. As of the date hereof, none of Borrower or any of
Borrower’s Subsidiaries has any contingent obligations, liability for taxes or other outstanding obligations which are material in the aggregate, except as disclosed in the most recent audited Financial Statements (including the notes thereto)
furnished by Borrower to Agent prior to the date hereof. 
 Section 4.10 Taxes. Each of Borrower and its Subsidiaries has filed or
caused to be filed all tax returns that are required to be filed by it except where the failure to do so could not reasonably be expected to have a Material Adverse Effect. Borrower and Borrower’s Subsidiaries have paid, or made provision for
the payment of, all Taxes which have or may have become due pursuant to said returns or otherwise, except such Taxes, if any, which are being contested in good faith and as to which adequate reserves (determined in accordance with generally accepted
accounting principles) have been provided or which could not reasonably be expected to have a Material Adverse Effect if unpaid. 
 Section 4.11
Catastrophic Events; Labor Disputes. Neither Borrower nor Borrower’s Subsidiaries and none of their properties is or has been affected by any fire, explosion, accident, strike, lockout or other labor dispute, drought, storm, hail,
earthquake, embargo, act of God or other casualty that could reasonably be expected to have a Material Adverse Effect. There are no disputes presently subject to grievance procedure, arbitration or litigation under any of the collective bargaining
agreements, employment contracts or employee welfare or incentive plans to which Borrower or Borrower’s Subsidiaries is a party, and there are no strikes, lockouts, work stoppages or slowdowns, or, to the best knowledge of Borrower,
jurisdictional disputes or organizing activity occurring or threatened which could reasonably be expected to have a Material Adverse Effect. 
  

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 Section 4.12 No Material Adverse Effect. No event has occurred and no condition exists (excluding
general economic conditions) which could reasonably be expected to have a Material Adverse Effect. 
 Section 4.13 First Priority.
Assuming the timely filing of financing statements covering the Collateral and, if applicable, the execution of the agreements referenced in Section 3.01(a)(ix) above, the security interest granted hereby constitutes a first priority security
interest in and Lien on all of the Collateral, subject only to Permitted Liens. 
 Section 4.14 Principal Place of Business. Borrower is
incorporated in the jurisdiction stated in the first sentence of this Loan Agreement, and the office where Borrower will keep all records and files regarding the Collateral is set forth in Section 9.07. Except as disclosed on
Schedule 2, Borrower has not done business under any name other than that specified on the signature page hereof. All Borrower’s Inventory and Equipment is located only at the locations set forth in Section 9.07 or on
Schedule 2 or at such other locations as are permitted under Section 5.12. 
 Section 4.15 Intellectual Property.
Borrower is the sole owner of the Intellectual Property, except for non-exclusive licenses granted by Borrower to its customers in the ordinary course of business. No part of the Intellectual Property has been judged invalid or unenforceable, in
whole or in part, and no claim has been made that any part of the Intellectual Property violates the rights of any third party. 
 Section 4.16
Investments. Borrower does not own any Investments in any Person, except for Permitted Investments. 
 Article 5. COVENANTS OF BORROWER.

 While any Obligations or unfunded Commitments remain outstanding: 
 Section 5.01 Financial Statements. Borrower shall provide to Agent the financial statements specified in this Section 5.01, prepared in accordance with generally accepted accounting principles, consistently applied
(except, in the case of unaudited financial statements, for the absence of footnotes and normal year-end adjustments); provided, however, that after the effective date of the initial registration statement covering a public offering of
Borrower’s securities, Borrower shall only be required to deliver those financial statements required to be filed by the Securities and Exchange Commission, to be provided as soon as practicable and no less frequently than quarterly.

  

	 	(a)	As soon as practicable (and in any event within thirty (30) days after the end of each month), an unaudited balance sheet as of the end of such month and unaudited statements
of income or loss, retained earnings or deficit, cash flows and capital structure of Borrower for such month, certified by Borrower’s Chief Executive Officer, Chief Financial Officer or Chief Business Officer to fairly present in all material
respects the data reflected therein. 

  

	 	(b)	As soon as practicable (and in any event within one hundred twenty (120) days after the end of each fiscal year), audited balance sheets as of the end of such year
(consolidated if applicable), and related statements of income or loss, retained earnings or deficit, cash flows and capital structure of Borrower for such year, setting forth in comparative form the corresponding figures for the preceding fiscal
year, and accompanied by an audit report and unqualified opinion of the independent certified public accountants of recognized national standing selected by Borrower. 

 Section 5.02 Other Information. Borrower shall promptly provide to Agent: (a) copies of all board packages delivered to its board of directors in connection with board meetings or otherwise,
provided that Agent shall maintain the confidentiality of all proprietary Borrower information acquired pursuant to this 

  

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Agreement and shall not disclose or use such information other than for a Borrower purpose or with the Borrower’s consent, (b) notice of all
actions, suits and proceedings before any court or governmental department, commission, board, bureau, agency or instrumentality, domestic or foreign, which suits or proceedings if decided adversely to Borrower could reasonably be expected to result
in costs or damages to Borrower of Fifty Thousand Dollars ($50,000) or more, (c) notice of any Default, Event of Default, Event of Loss, or any matter which has resulted or may reasonably be expected to result in a Material Adverse Effect, and
(d) any additional information (including but not limited to tax returns, income statements, balance sheets, and names of principal creditors) as Agent shall reasonably request which is necessary to evaluate Borrower’s continuing financial
obligations. 
 Section 5.03 Corporate Identity. Borrower shall notify Agent in writing thirty (30) days prior to any change in
Borrower’s principal place of business or chief executive office and any change of Borrower’s name, identity or corporate structure. 
 Section
5.04 Equity Investment. Borrower shall permit Agent and the Lenders, at their option, to purchase in Borrower’s next round of private equity financing the securities sold in such equity financing at the same price and on the
same terms as paid and received by the lead investor of the equity financing in an aggregate amount of up to the lesser of $1,000,000 or Seven and One-Half percent (7.5%) of the aggregate amount of the equity financing (the “Participation
Right”). Borrower agrees that it shall notify Agent promptly upon the execution by Borrower of a term sheet or letter of intent setting forth the terms and conditions of such financing (the “Financing Notice”) and in any event within
five (5) days of such execution. Agent and the Lenders shall be entitled to exercise their Participation Right by delivery of written notice thereof to Borrower; provided that such Participation Right shall expire if such notice is not
delivered by Agent and/or the Lenders to Borrower within fifteen (15) days of Agent’s receipt of the Financing Notice. Agent and the Lenders may assign their Participation Right to their Affiliates upon prior written notice to Borrower.

 Section 5.05 Authorization for Automated Clearinghouse Funds Transfer. Borrower shall (i) authorize Agent to initiate debit
entries to Borrower’s account specified in Section 9.06 (“Borrower’s Primary Operating Account”) through Automated Clearinghouse (“ACH”) transfers, in order to satisfy regularly
scheduled payments of principal, interest and fees; (ii) provide Agent at least thirty (30) days notice of any change in Borrower’s Primary Operating Account; and (iii) grant Agent any additional authorizations necessary to begin
ACH debits from a new account which becomes Borrower’s Primary Operating Account. 
 Section 5.06 Insurance. Borrower shall, at its
own expense, maintain the following types of insurance, with companies with an A-5 Best rating or better, in amounts acceptable to Agent: 
  

	 	(a)	All Risk. “All risk” insurance against loss or damage to the Collateral. The deductible shall not exceed $25,000. The policy shall name Agent as a loss payee with
respect to the Collateral, shall not be invalidated by any action of or breach of warranty by Borrower of any provision thereof and shall waive subrogation against Agent. 

  

	 	(b)	General Liability Insurance. Commercial general liability insurance (including contractual liability, products liability and completed operations coverages) reasonably
satisfactory to Agent. The limit of liability shall be at least $2,000,000 per occurrence. The policy shall be without deductible, except for products liability coverage which may have a deductible up to $25,000. The policy(ies) shall name Agent as
additional insured in the full amount of Borrower’s liability coverage limits (or the coverage limits of any successor to Borrower or such successor’s parent which is providing coverage), be primary and without contribution as respects any
insurance carried by Agent and contain cross liability and severability of interest clauses. 

  

	 	(c)	Other Insurance. Such other insurance against risks of loss and with terms as shall be reasonably required by Agent. 

  

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 All policies of insurance shall provide that Agent shall be given thirty (30) days notice of cancellation of
coverage. This notice provision shall be without qualification. On or prior to the first Funding Date and prior to each policy renewal, Borrower shall furnish to Agent, certificates of insurance or other evidence satisfactory to Agent that insurance
complying with all of the above requirements is in effect. 
 Section 5.07 Taxes and Other Liabilities. Borrower shall pay all
Indebtedness when due; pay all Taxes and other governmental or regulator assessments before delinquency or before any penalty attaches thereto, except as may be contested in good faith by the appropriate procedures and for which Borrower shall
maintain appropriate reserves; and timely file all required tax returns. 
 Section 5.08 Title. Borrower shall promptly notify Agent in
writing of any event which materially affects the value of the Collateral, the ability of Borrower or Agent to dispose of the Collateral, or the rights or remedies of Agent in relation thereto, including, but not limited to, the levy of any legal
process against the Collateral. Upon request by Agent, Borrower shall deliver to Agent any and all evidence of ownership of, and certificates of title to, any and all of the Equipment. 
 Section 5.09 Further Identification of Collateral. Borrower shall promptly advise Agent of any material change in the composition of the Collateral, and shall also furnish to Agent from time to
time such statements and schedules further identifying and describing the Collateral and such other reports in connection with the Collateral as Agent may reasonably request, all in reasonable detail. 
 Section 5.10 Good Repair. Borrower shall keep and maintain all Collateral in good operating condition and repair, subject to ordinary wear and tear,
make all necessary repairs thereto and replacement of parts thereof so that the value and operating efficiency thereof shall at all times be maintained and preserved in all material respects; and Borrower shall keep books and records with respect to
the Collateral, including maintenance records, which are complete and accurate in all material respects. 
 Section 5.11 Loss; Damage; Destruction and
Seizure. 
  

	 	(a)	If while payment Obligations are outstanding any item of Collateral is lost, stolen, destroyed, damaged beyond repair or seized by a Governmental Authority (an “Event of
Loss”), then, at Borrower’s option, either (i) Agent shall receive from the proceeds of insurance maintained pursuant to Section 5.06, from any award paid by the seizing Governmental Authority or, to the extent not
received from the proceeds of insurance or award or both, from Borrower, on or before the next scheduled Payment Date succeeding such Event of Loss, an amount equal to the replacement value of the item of Collateral subject to the Event of Loss
which shall be held as additional Collateral for the Advance, or (ii) if no Event of Default has occurred and is continuing, Borrower may use any such proceeds to purchase an item of Collateral to replace the item of Collateral which was
subject to the Event of Loss and such replacement Collateral shall become part of the Collateral. On the date of receipt by Agent of the amount specified hereinabove with respect to each such item of Collateral subject to an Event of Loss, the
provisions of this Loan Agreement shall terminate as to such Collateral. Pending Borrower’s election of the options set forth above, any proceeds of insurance maintained by Borrower with respect to the Collateral pursuant to Section 5.06
and received by Borrower shall be paid to Agent promptly upon their receipt by Borrower. If any proceeds of insurance or awards received from Governmental Authorities are in excess of the amount owed under this Section 5.11(a), Agent shall
promptly remit to Borrower the amount in excess of the amount to be held by Agent. 

  

	 	(b)	 So long as no Event of Default has occurred and is continuing, any proceeds of insurance maintained pursuant to Section 5.06 received by Agent or Borrower with
respect to an item of Collateral the repair of which is practicable shall, at the election of Borrower, be applied either to the repair or replacement of such Collateral or, upon Agent’s receipt of evidence of the repair or replacement of the
Collateral reasonably satisfactory to Agent, to the reimbursement of Borrower for the cost of such repair or replacement. All replacement parts and equipment acquired by Borrower in replacement of 

  

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Collateral pursuant to this Section 5.11 shall immediately become part of the Collateral upon acquisition by Borrower. Borrower shall take such actions
and provide such documentation as may be reasonably requested by Agent to protect and preserve Agent’s first priority security interest and otherwise to avoid any impairment of Agent’s rights under the Transaction Documents, in connection
with such repair or replacement. 

 Section 5.12 Collateral Control. Borrower shall not (i) terminate, waive or
release any material right with respect to any Collateral, or (ii) remove any items of Collateral from Borrower’s facility located at the address specified in Section 9.07, the locations specified on Schedule 2, or such
other address agreed to in writing by Lender. 
 Section 5.13 Liens; No Disposition of Collateral. Borrower shall not (i) in any
way hypothecate or create or permit to exist any Lien with respect to any of its or its Subsidiaries’ property, except for Permitted Liens, (ii) permit the inclusion in any contract to which it or a Subsidiary becomes a party of any
provisions that could restrict or invalidate the creation of a security interest in any of Borrower’s or such Subsidiary’s property, or (iii) sell, transfer, assign, pledge, collaterally assign, exchange, or otherwise dispose of
(collectively, a “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, other than Transfers: (A) of Inventory in the ordinary course of business, (B) of non-exclusive licenses
and similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of business, (C) of worn-out or obsolete Equipment, or (D) by Borrower to its Subsidiaries in an aggregate amount not to exceed
$100,000 on an annual basis. 
 Section 5.14 Mergers and Acquisitions. Without the prior written consent of Agent, which shall not be
unreasonably withheld, Borrower shall not be acquired by any “person” (as such term is used in Section 13(d) and 14(d) of the Securities Exchange Act of 1934), whether by merger or consolidation, or through a transaction or series of
transactions pursuant to which the holders of Borrower’s voting Equity Securities do not hold at least 50% of the voting power of Borrower or any resulting Person after such transaction or transactions, or through the sale of all or
substantially all of its assets, unless (i) the Obligations are assumed or guarantied by a Person which is the ultimate parent entity (the “Acquirer”) of the acquiring Person and (ii) the Acquirer is a creditworthy
entity (as determined by Agent in its reasonable discretion). 
 Section 5.15 Distributions. Prior to the effective date of the initial
registration statement covering a public offering of Borrower’s securities, without the prior written consent of Agent, Borrower shall not (i) pay any dividends or make any distributions on its Equity Securities; (ii) purchase,
redeem, retire, defease or otherwise acquire for value any of its Equity Securities (other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements or similar arrangements in an aggregate amount
not to exceed $100,000 per calendar year); (iii) return any capital to any holder of its Equity Securities as such; (iv) make any distribution of assets, Equity Securities, obligations or securities to any holder of its Equity Securities
as such; or (v) set apart any sum for any such purpose; provided, however, Borrower may declare dividends payable solely in common stock. 
 Section 5.16 Indebtedness. Borrower shall not, and shall not permit its Subsidiaries to, create, incur, assume or suffer to exist any Indebtedness, other than Permitted Indebtedness. 
 Section 5.17 Investments. Borrower shall not, and shall not permit its Subsidiaries to, directly or indirectly acquire or own, or make any
Investment in or to any Person other than Permitted Investments; or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary from paying dividends or otherwise distributing property to Borrower.

 Section 5.18 Transactions with Affiliates. Borrower shall not, and shall not permit its Subsidiaries to, directly or indirectly enter
into or permit to exist any material transaction with any Affiliate, except for transactions that are in the ordinary course of such Person’s business, upon fair and reasonable terms that are no less favorable to Borrower, or such Subsidiary,
than would be obtained in an arms’ length transaction with a non-affiliated Person; provided that the foregoing restriction shall not apply to (i) any transaction 

  

 -9- 

 
between Borrower and any of its Subsidiaries or between any Subsidiaries that is not otherwise prohibited by this Loan Agreement, (ii) reasonable and
customary fees paid to members of the board of directors of Borrower and its Subsidiaries, and (iii) compensation arrangements and benefit plans for officers and other employees of Borrower and its Subsidiaries entered into or maintained in the
ordinary course of business. 
 Section 5.19 Indebtedness Payments. Other than repayment of the indebtedness to Comerica Bank as set
forth on Schedule 2 upon receipt of the first advance under this Loan Agreement, Borrower shall not (i) prepay, redeem, purchase, defease or otherwise satisfy in any manner prior to the scheduled repayment thereof any Indebtedness for borrowed
money (other than amounts due or permitted to be prepaid under this Loan Agreement) or any lease obligations, (ii) amend, modify or otherwise change the terms of any Indebtedness (other than the Advances) or lease obligations so as to
accelerate the scheduled repayment thereof or (iii) repay any Indebtedness to officers, directors or shareholders. 
 Section 5.20
Accounts. Borrower shall not, and shall not permit its Subsidiaries to, maintain any deposit accounts or securities accounts except accounts with respect to which Agent has obtained an agreement with the bank or other financial
institution sufficient to perfect a security interest in such deposit accounts or securities accounts. 
 Article 6. PRESERVATION OF COLLATERAL BY AGENT.

 Should Borrower fail or refuse to make any payment, perform or observe any other covenant, condition or obligation, or take any other
action which Borrower is obligated under any Transaction Document to make, perform, observe, take or do at the time or in the manner provided in any Transaction Document, then at Agent ‘s sole and absolute discretion, without notice to or
demand upon Borrower and without releasing Borrower from any obligation, covenant or condition in any Transaction Document, Agent may make, perform, observe, take or do the same in such manner and to such extent as Agent may deem necessary to
protect its security interest in or the value of the Collateral. In furtherance of the foregoing rights, Borrower does hereby irrevocably appoint Agent (which appointment is coupled with an interest), the true and lawful attorney-in-fact of Borrower
with full power of substitution, for it and in its name (i) to perform (but Agent shall not be obligated to and shall incur no liability to Borrower or any third party for failure to perform) any act which Borrower is obligated by this Loan
Agreement to perform, (ii) to ask, demand, collect, receive, receipt for, sue for, compound and give acquittance for any and all rents, issues, profits, avails, distributions, income, payment draws and other sums in which a security interest is
granted under Section 2.01 with full power to settle, adjust or compromise any claim thereunder as fully as if Agent were Borrower itself, (iii) to receive payment of and to endorse the name of Borrower to any items of Collateral
(including checks, drafts and other orders for the payment of money) that come into Agent’s possession or under Agent ‘s control, (iv) to make all demands, consents and waivers, or take any other action with respect to, the
Collateral, (v) in Agent ‘s discretion, to file any claim or take any other action or institute proceedings, either in its own name or in the name of Borrower or otherwise, which Agent may reasonably deem necessary or appropriate to
protect and preserve the right, title and interest of Agent in and to the Collateral, and (vi) to otherwise act with respect thereto as though Agent were the outright owner of the Collateral; provided, however, that the power of
attorney herein granted shall be exercisable only upon the occurrence and during the continuation of an Event of Default unless in Agent ‘s reasonable opinion immediate action is necessary to preserve or protect the Collateral. Borrower agrees
to reimburse Agent upon demand for all reasonable costs and expenses, including attorneys’ fees and expenses, which Agent may incur while acting as Borrower’s attorney in fact or otherwise under this Article 6, all of which costs and
expenses are included within the Obligations. 
  

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 Article 7. EVENTS OF DEFAULT. 
 Section 7.01 Events of Default. The occurrence of any of the following shall constitute an “Event of Default” under the Transaction Documents: 
  

	 	(a)	Failure to Pay. Borrower shall fail to pay when due any principal, interest or other payment required under the terms of this Loan Agreement or any other Transaction Document
on the date due and such payment shall not have been made within three (3) Business Days of the due date; or 

  

	 	(b)	Insurance. Borrower or any of its Subsidiaries shall fail to observe or perform any covenant set forth in Section 5.06 and such failure shall continue for a period of
ten (10) Business Days after notice thereof is given to Borrower by Agent; or 

  

	 	(c)	Breaches of Other Covenants. Borrower or any of its Subsidiaries shall fail to perform or observe (i) any of the terms, covenants or agreements contained in
Sections 5.03, 5.05, or 5.11 through 5.20 hereof or (ii) any other term, covenant, or agreement contained in any Transaction Document (other than the other Events of Default specified in this Article 7) and such failure remains
unremedied for the earlier of twenty (20) days from (x) the date on which the Agent has given the Borrower written notice of such failure and (y) the date on which the Borrower knew or should have known of such failure; or

  

	 	(d)	Representations and Warranties. Any representation, warranty, certificate, or other statement (financial or otherwise) made or furnished by or on behalf of Borrower to Agent
in writing in connection with this Loan Agreement or any of the other Transaction Documents, or as an inducement to Agent or Lenders to enter into the Transaction Documents, shall be false, incorrect, incomplete or misleading in any material respect
when made or furnished; or 

  

	 	(e)	Other Payment Obligations. Borrower or any of its Subsidiaries shall fail to make any payment when due under the terms of any Indebtedness to be paid by such Person
(excluding this Loan Agreement and the other Transaction Documents but including any other Indebtedness of Borrower or any of its Subsidiaries to Agent or any Lender) and such failure shall continue beyond any period of grace provided with respect
thereto, or shall default in the observance or performance of any other agreement, term or condition contained in any such Indebtedness, and the effect of such failure or default is to cause, or permit the holder or holders thereof to cause
Indebtedness in an aggregate amount of One Hundred Thousand Dollars ($100,000) or more to become due prior to its stated date of maturity; or 

  

	 	(f)	Voluntary Bankruptcy or Insolvency Proceedings. Borrower or any of its Subsidiaries shall (i) apply for or consent to the appointment of a receiver, trustee, liquidator
or custodian of itself or of all or a substantial part of its property, (ii) be unable, or admit in writing its inability, to pay its debts generally as they mature, (iii) make a general assignment for the benefit of its or any of its
creditors, (iv) be dissolved or liquidated in full or in part, (v) become insolvent (as such term may be defined or interpreted under any applicable statute), (vi) commence a voluntary case or other proceeding seeking liquidation,
reorganization or other relief with respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or consent to any such relief or to the appointment of or taking possession of its property by any
official in an involuntary case or other proceeding commenced against it, or (vii) take any action for the purpose of affecting any of the foregoing; or 

  

	 	(g)	 Involuntary Bankruptcy or Insolvency Proceedings. Proceedings for the appointment of a receiver, trustee, liquidator or custodian of Borrower or any of its
Subsidiaries or of all or a substantial part of the property thereof, or an involuntary case or other proceedings seeking liquidation, reorganization or other relief with respect to Borrower or any of its Subsidiaries or the debts thereof under any
bankruptcy, insolvency or other similar law now or hereafter in effect shall be commenced and an 

  

 -11- 

	 	 
order for relief entered or such proceeding shall not be dismissed or discharged within thirty (30) days of commencement; or

  

	 	(h)	Judgments. A final judgment or order for the payment of money in excess of One Hundred Thousand Dollars ($100,000) shall be rendered against Borrower or any of its
Subsidiaries and the same shall remain undischarged for a period of thirty (30) days during which execution shall not be effectively stayed, or any judgment, writ, assessment, warrant of attachment, or execution or similar process shall be
issued or levied against a substantial part of the property of Borrower or any of its Subsidiaries and such judgment, writ, or similar process shall not be released, stayed, vacated or otherwise dismissed within thirty (30) days after issue or
levy; or 

  

	 	(i)	Transaction Documents. Any Transaction Document or any material term thereof shall cease to be, or be asserted by Borrower not to be, a legal, valid and binding obligation of
Borrower enforceable in accordance with its terms or if the Liens of Agent in the Collateral shall cease to be or shall not be valid, first priority perfected Liens or Borrower shall assert that such Liens are not valid, first priority and perfected
Liens. 

 Article 8. AGENT’S RIGHTS AND REMEDIES 
 Section 8.01 Rights of Agent upon Default. Upon the occurrence and during the existence of any Event of Default (other than an Event of Default referred to in Sections 7.01(f) and 7.01(g))
and at any time thereafter during the continuance of such Event of Default, Agent may, by written notice to Borrower, declare all outstanding Obligations, including, without limitation, the non-cancelable obligation to make each payment scheduled to
be made under Sections 1.02(b), 1.02(c) and 1.02(d), payable by Borrower hereunder to be immediately due and payable without presentment, demand, protest or any other notice of any kind, all of which are hereby expressly waived, anything contained
herein or in the Notes to the contrary notwithstanding. Upon the occurrence or existence of any Event of Default described in Sections 7.01(f) and 7.01(g), immediately and without notice, all outstanding Obligations, including, without
limitation, the non-cancelable obligation to make each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d), payable by Borrower hereunder shall automatically become immediately due and payable, without presentment, demand,
protest or any other notice of any kind, all of which are hereby expressly waived, anything contained herein or in the Notes to the contrary notwithstanding. 
 Section 8.02 Rights Regarding Collateral. Borrower agrees that when any Event of Default has occurred and is continuing, Lenders or Agent, on behalf of Lenders, shall have the rights, options, duties and remedies of a
secured party as permitted by law and, in addition to and without limiting the foregoing, Lenders or Agent may, at the election of Lenders, exercise any one or more or all, and in any order, of the remedies herein set forth, including the following:
(i) Agent or Lenders, personally or by agents or attorneys, shall have the right (subject to compliance with any applicable mandatory legal requirements) to require Borrower to assemble the Collateral and make it available to Agent at a place
to be designated by Agent in California or to take immediate possession of the Collateral, or any portion thereof, and for that purpose may pursue the same wherever it may be found, and may enter any premises of Borrower, with or without notice,
demand, process of law or legal procedure, to the extent permitted by applicable law, and search for, take possession of, remove, keep and store the same, or use and operate or lease the same until sold; (ii) Agent or Lenders may, if at the
time such action may be lawful and always subject to compliance with any mandatory legal requirements, either with or without taking possession and either before or after taking possession, without instituting any legal proceedings whatsoever,
having first given notice of such sale by registered or certified mail to Borrower once at least ten (10) days prior to the date of such sale, and having first given any other notice which may be required by law, sell and dispose of the
Collateral, or any part thereof, at a private sale or at public auction, to the highest bidder, in one lot as an entirety or in separate lots, and either for cash or on credit and on such terms as Lenders may determine, and at any place (whether or
not it be the location of the Collateral or any part thereof) designated in the notice referred to above. Agent and its agents and any purchasers at or after foreclosure are hereby granted a non-exclusive, irrevocable, perpetual, fully paid,
royalty-free license or other right, solely pursuant to the provisions of this Section 8.02, to use, without charge, 

  

 -12- 

 
Borrower’s intellectual property that remains embedded or contained in the Collateral, including without limitation, labels, patents, copyrights, rights
of use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, now or at any time hereafter owned or acquired by Borrower or in which Borrower now or at any time hereafter has
any rights; provided, however, such license shall only be exercisable in connection with the disposition of Collateral upon Agent’s or Lenders’ exercise of their remedies hereunder. To the extent permitted by applicable law,
any such sale or sales may be adjourned from time to time by announcement at the time and place appointed for such sale or sales, or for any such adjourned sale or sales, without further published notice, and Borrower, Agent, Lenders, or the holder
or holders of the Note, or of any interest therein, may bid and become the purchaser at any such sale; and (iii) Agent or Lenders may proceed to protect and enforce this Loan Agreement and the other Transaction Documents by suit or suits or
proceedings in equity, at law or in bankruptcy, and whether for the specific performance of any covenant or agreement herein contained or in execution or aid of any power herein granted; or for foreclosure hereunder, or for the appointment of a
receiver or receivers for any real property security or any part thereof, or for the recovery of judgment for the Obligations or for the enforcement of any other proper, legal or equitable remedy available under applicable law. With respect to any
of Borrower’s owned premises, Borrower hereby grants Agent a license to enter into possession of such premises and to occupy the same, without charge, for up to one hundred twenty (120) days in order to exercise any of Agent’s or
Lenders’ rights or remedies provided herein, at law, in equity, or otherwise. 
 Section 8.03 Agent’s Liability for
Collateral. So long as Agent complies with its obligations, if any, under the Code, neither Agent nor Lenders shall in any way or manner be liable or responsible for: (i) the safekeeping of the Collateral; (ii) any loss or damage
thereto occurring or arising in any manner of fashion from any cause other than Agent’s or such Lender’s gross negligence or willful misconduct; (iii) any diminution in the value thereof; or (iv) any act or default of any
carrier, warehouseman, bailee, forwarding agency, or other Person whomsoever. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 
 Section 8.04 Application of Collateral Proceeds. The proceeds and/or avails of the Collateral, or any part thereof, and the proceeds and the avails of any remedy hereunder (as well as any other amounts of any kind held
by Agent at the time of, or received by Agent after, the occurrence of an Event of Default hereunder) shall be paid to and applied as follows: (i) First, to the payment of reasonable costs and expenses, including all amounts expended to
preserve the value of the Collateral, of foreclosure or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper fees, expenses, liability and advances, including reasonable legal expenses and
attorneys’ fees, incurred or made hereunder by Agent or Lenders; (ii) Second, to the payment to Lenders pro rata in accordance with the Advance Percentages of the amounts then owing or unpaid on the Notes, including each payment scheduled
to be made under Sections 1.02(b), 1.02(c) and 1.02(d) of this Loan Agreement; (iii) Third, to the payment of other amounts then payable to Agent or Lenders under any of the Transaction Documents; and (iv) Fourth, to the payment of the
surplus, if any, to Borrower, its successors and assigns, or to whomsoever may be lawfully entitled to receive the same. In the event that, notwithstanding the foregoing, proceeds and/or avails of the Collateral, shall be received by a Lender in
excess of its ratable share, then the portion of such payment or distribution in excess of such Lender’s ratable share shall be received by such Lender in trust for and shall be promptly paid over to the other Lenders ratably for application to
the payments of amounts due to the other Lenders. 
 Section 8.05 Reinstatement of Rights. If Agent shall have proceeded to enforce any
right under this Loan Agreement or any other Transaction Document by foreclosure, sale, entry or otherwise, and such proceedings shall have been discontinued or abandoned for any reason or shall have been determined adversely, then and in every such
case (unless otherwise ordered by a court of competent jurisdiction), Agent shall be restored to its former position and its rights hereunder with respect to the property subject to the security interest created under this Loan Agreement shall be
reinstated. 
 Section 8.06 Agency for Perfection. Each Lender hereby appoints Agent and each other Lender as agent and bailee for the
purpose of perfecting the security interests in and liens upon the Collateral in assets which, in accordance with the California Uniform Commercial Code, can be perfected only by possession or 
  

 -13- 

 
control (or where the security interest of a secured party with possession or control has priority over the security interest of another secured party) and
Agent and each Lender hereby acknowledges that it holds possession or control of any such Collateral for the benefit of the Agent as secured party. Should any Lender obtain possession or control of any such Collateral, such Lender shall notify the
Agent thereof, and, promptly upon the Agent’s request therefor shall deliver possession or control of such Collateral to the Agent or in accordance with the Agent’s instructions. Borrower by its execution and delivery of
this Loan Agreement hereby consents to the foregoing. 
 Article 9. MISCELLANEOUS. 
 Section 9.01 Modifications, Amendments or Waivers. The provisions of any Transaction Document may be modified, amended or waived only by a written instrument signed by the parties thereto.

 Section 9.02 No Implied Waivers; Cumulative Remedies; Writing Required. No delay or failure of Agent or any Lender in exercising any
right, power or remedy hereunder shall affect or operate as a waiver thereof; nor shall any single or partial exercise thereof or any abandonment or discontinuance of steps to enforce such a right, power or remedy preclude any further exercise
thereof or of any other right, power or remedy. The rights and remedies hereunder of Agent and the Lenders are cumulative and not exclusive of any rights or remedies which they would otherwise have. Any waiver, permit, consent or approval of any
kind or character on the part of Agent or any Lender of any breach or default under this Loan Agreement or any such waiver of any provision or condition of this Loan Agreement must be in writing and shall be effective only in the specified instance
and to the extent specifically set forth in such writing. 
 Section 9.03 Reimbursement. Borrower shall reimburse Agent and the Lenders
for all costs and expenses, including without limitation, reasonable attorneys’ fees and disbursements expended or incurred in any arbitration, mediation, judicial reference, legal action or otherwise in connection with (i) the amendment
and enforcement of the Transaction Documents, including without limitation during any workout, attempted workout and/or in connection with the rendering of legal advice as to Agent’s or Lenders’ rights, remedies and obligations under the
Transaction Documents, (ii) collecting any sum which becomes due Agent or Lender under any Transaction Document, (iii) any proceeding for declaratory relief, any counterclaim to any proceeding, or any appeal, or (v) the protection,
preservation or enforcement of any rights of Agent or Lender. For the purpose of this section, attorneys’ fees shall include, without limitation, fees incurred in connection with the following: (1) contempt proceedings; (2) discovery,
(3) any motion, proceeding or other activity of any kind in connection with an insolvency proceeding; (4) garnishment, levy, and debtor and third party examinations; and (5) post-judgment motions and proceedings of any kind, including
without limitation, any activity taken to collect or enforce any judgment. All of the foregoing costs and expenses shall be payable by Borrower upon demand by Agent, and if not paid within thirty (30) days of presentation of invoices shall bear
interest at the highest applicable Default Rate. 
 Section 9.04 Indemnification. Borrower agrees upon demand to pay or reimburse Agent
and the Lenders for all liabilities, obligations and out-of-pocket expenses, including reasonable fees and expenses of counsel for Agent and the Lenders, from time to time arising in connection with the enforcement or collection of sums due under
the Transaction Documents. Borrower shall indemnify, reimburse and hold Agent and the Lenders and their permitted assigns, each of Agent’s, Lenders’ or their permitted assigns’ partners, and each of their respective successors,
assigns, agents, officers, directors, shareholders, servants, agents and employees harmless from and against all liabilities, losses, damages, actions, suits, demands, claims of any kind and nature (including claims relating to environmental
discharge, cleanup or compliance), all costs and expenses whatsoever to the extent they may be incurred or suffered by such indemnified party in connection therewith (including reasonable attorneys’ fees and expenses), fines, penalties (and
other charges of applicable governmental authorities), licensing fees relating to any item of Collateral, damage to or loss of use of property (including consequential or special damages to third parties or damages to Borrower’s property), or
bodily injury to or death of any person (including any agent or employee of Borrower) (each, a “Claim”), directly or indirectly relating to or arising out of the use of the proceeds of the Advance, including acquisition, use,
ownership, operation, possession, control, storage, return or condition of any item of Equipment 

  

 -14- 

 
constituting Collateral (regardless of whether such item of Equipment is at the time in the possession of Borrower), the falsity of any representation or
warranty of Borrower or Borrower’s failure to comply with the terms of this Loan Agreement or any other Transaction Document. The foregoing indemnity shall cover, without limitation, (i) any Claim in connection with a design or other
defect (latent or patent) in any item of Equipment constituting Collateral, (ii) any Claim for infringement of any patent, copyright, trademark or other intellectual property right, (iii) any Claim resulting from the presence on or under
or the escape, seepage, leakage, spillage, discharge, emission or release of any Hazardous Materials from any item of Equipment financed by an Advance or constituting Collateral, including any Claims asserted or arising under any Environmental Law,
or (iv) any Claim for negligence or strict or absolute liability in tort; provided, however, that Borrower shall not indemnify Agent or any Lender for any liability incurred by such Person as a direct and sole result of that
Person’s gross negligence or willful misconduct. Such indemnities shall continue in full force and effect, notwithstanding the expiration or termination of this Loan Agreement. Upon Agent’s written demand, Borrower shall assume and
diligently conduct, at its sole cost and expense, the entire defense of Agent or any Lender and its permitted assigns, each of Agent’s, Lenders’ or their permitted assigns’ partners, and each of their respective successors, assigns,
agents, officers, directors, shareholders, servants, agents and employees against any indemnified Claim described in this Section 9.04. Borrower shall not settle or compromise any Claim against or involving Agent or any Lender without first
obtaining such Person’s written consent thereto, which consent shall not be unreasonably withheld. The obligations in this Section 9.04 shall survive payment of all other Obligations until all applicable statute of limitation periods with
respect to actions that may be brought against Agent or Lenders have run. All amounts owing under this Section 9.04 shall be paid within thirty (30) days after written demand. 
 Section 9.05 Limitation on Damages. NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS LOAN AGREEMENT OR ANYWHERE ELSE, BORROWER AGREES THAT IT SHALL NOT SEEK FROM AGENT OR ANY LENDER
UNDER ANY THEORY OF LIABILITY (INCLUDING ANY THEORY IN TORTS), ANY SPECIAL, INDIRECT, CONSEQUENTIAL OR PUNITIVE DAMAGES. 
 Section 9.06
Disbursements and Payments. 
  

	 	(a)	Disbursements. Lenders shall disburse each Advance to Borrower according to the following account and wire transfer instructions: 

  

			
	Credit:	  	Phenomix Corporation
	Bank Name:	  	Comerica Bank / Branch 942
	Bank Address:	  	 11943 El Camino Real, Suite #110A
 San Diego, CA 92130

		
	Account Number:	  	
	ABA Routing Number:	  	121137522
	Reference:	  	Pinnacle Advance

  

 -15- 

	 	(b)	Regularly Scheduled Payments. All regularly scheduled payments due to Agent shall be effected by automatic debit of the appropriate funds from Borrower’s primary
operating account set forth below: 

  

			
	Account Holder:	  	Phenomix Corporation
	Bank Name:	  	Comerica Bank / Branch 942
	Bank Address:	  	11943 El Camino Real, Suite #110A
	Account Number:	  	
	ABA Routing Number:	  	121137522

  

	 	(c)	Other Payments. All payments to Agent other than regularly scheduled payments may be made via wire transfer as follows: 

  

			
	Wire Transfer Payment	  	
		
	Credit:	  	Pinnacle Ventures L.L.C.
	Bank Name:	  	Wells Fargo Bank
	Bank Address:	  	400 Hamilton Avenue, Palo Alto, CA 94302
	Account Number:	  	
	ABA Routing Number:	  	121000248
	Reference:	  	Phenomix Corporation

 Section 9.07 Notices. All notices and other communications given to or made upon any party
hereto in connection with this Loan Agreement shall be in writing and (except for financial statements and other informational documents which may be sent by email) shall be delivered by certified mail, postage prepaid, return receipt requested, by
a nationally recognized overnight courier, or by prepaid facsimile or personally delivered to the respective parties, as follows: 
  

			
	Borrower:	  	 PHENOMIX CORPORATION
 5871 Oberlin Drive, Suite
200
 San Diego, CA 92121
 Telephone: 858.731.5200
 Telecopier: 858.731.5222
 Attention: Chris Burnley, EVP &
CBO

		
	Agent:	  	 PINNACLE VENTURES, L.L.C.
 130 Lytton Avenue,
Suite 220
 Palo Alto, CA 94301
 Telephone: (650) 926-7800

 Telecopier: (650) 926-7801
 Email: rsavoie@pinnacleven.com

 Attention: Chief Financial Officer

 or in accordance with any subsequent written direction from either party to the other. All such notices and other
communications shall, except as otherwise expressly herein provided, be effective when received; or in the case of delivery by messenger or overnight delivery service, when left at the appropriate address. 
 Section 9.08 Lenders and Allocations of Advances. Notwithstanding anything herein to the contrary, each Lender severally commits to make such
Lender’s Advance Percentage of each Advance. No Lender shall have liability for the commitment to make Advances of any other Lender. Borrower agrees that by notice to Borrower, Agent may reallocate the Advance Percentages among the Lenders or
among the Lenders and other investment funds affiliated with Agent. Whether or not specified in any provision of this Loan Agreement, all references to Agent in this Loan Agreement shall mean Agent for the benefit of the Lenders unless the context
otherwise requires. 
  

 -16- 

 Section 9.09 Severability. If any provision of any Transaction Document is held invalid or
unenforceable to any extent or in any application, the remainder of such Transaction Document and all other Transaction Documents, or the application of such provision to different Persons or circumstances or in different jurisdictions, shall not be
affected thereby. 
 Section 9.10 Reliance by Agent and the Lenders. All covenants, agreements, representations and warranties made
herein by Borrower shall be deemed to have been relied upon by Agent and the Lenders, notwithstanding investigation by Agent. 
 Section 9.11 No
Set-Offs by Borrower. All sums payable by Borrower pursuant to this Loan Agreement or any of the other Transaction Documents shall be payable without notice or demand and shall be payable without set-off or reduction of any manner
whatsoever. 
 Section 9.12 Survival. All representations, warranties, covenants and agreements of Borrower contained herein or made in
writing in connection herewith shall survive the execution and delivery of the Transaction Documents, the making of Advances hereunder, the granting of security and the issuance of the Notes. 
 Section 9.13 Confidentiality. Agent and the Lenders agree to hold non-public information received in confidence and shall not disclose such
information to third parties except to their employees, members, partners or the partners of its affiliated investment funds, their lenders, and professional advisors to the foregoing, including attorneys and accountants, and others under a similar
duty of confidentiality, and as Agent may deem necessary in its reasonable judgment to satisfy its legal obligations or to enforce Agent’s or Lenders’ rights under any Transaction Document. Borrower acknowledges that Lenders may issue
press releases, advertisements, and other promotional materials, either in print or on Lenders’ website(s), describing any successful outcome of services provided on Borrower’s behalf. Upon the prior written consent of Borrower, which
shall not be unreasonably withheld, Lenders shall have the right to identify Borrower by name and use Borrower’s corporate logo in those materials, solely for marketing purposes. 
 Section 9.14 Choice of Law and Venue; Jury Trial Waiver. THIS LOAN AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA, WITHOUT REGARD TO
PRINCIPLES OF CONFLICTS OF LAW. BORROWER, AGENT AND THE LENDERS HEREBY SUBMIT TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS LOCATED IN THE NORTHERN DISTRICT OF CALIFORNIA. BORROWER, AGENT AND THE LENDERS HEREBY WAIVE THEIR RESPECTIVE
RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE TRANSACTION DOCUMENTS OR ANY OF THE TRANSACTIONS CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON
LAW OR STATUTORY CLAIMS. 
 Section 9.15 Successors and Assigns. This Loan Agreement and the other Transaction Documents shall be
binding upon and inure to the benefit of Agent and the Lenders, all future holders of the Note, Borrower and their respective successors and permitted assigns, except that Borrower may not assign or transfer its rights hereunder or thereunder or any
interest herein or therein without the prior written consent of Agent, which shall be deemed given if such consent has been granted under Section 5.14. Agent or Lenders may assign all or any portion of their rights hereunder and under one or
more Notes to any of its affiliated investment funds or to any one or more financial institutions or funds or an agent or trustee for such financial institutions or funds (an “Assignee”) and may sell to any of its affiliated
investment funds or to any one or more financial institutions or funds or an agent or trustee for such financial institutions or funds (a “Participant”) participation interests in Agent’s or Lenders’ rights
hereunder and under one or more Notes. Agent and the Lenders may disclose the Transaction Documents and any other financial or other information relating to Borrower or any Subsidiary to any potential Assignee or Participant, provided that such
Participant agrees to protect the confidentiality of such documents and information using the same measures that it uses to protect its own confidential information. 
  

 -17- 

 Section 9.16 Counterparts. This Loan Agreement may be executed in any number of counterparts and by
different parties hereto on separate counterparts, each of which, when so executed and delivered, shall be an original, but all such counterparts shall together constitute one and the same instrument. 
 Section 9.17 Further Assurances. Borrower will, at its own expense, from time to time do, execute, acknowledge and deliver all and every further
acts, deeds, conveyances, transfers and assurances, and all financing and continuation statements and similar notices, reasonably necessary or proper for the perfection of the security interest being herein provided for in the Collateral, whether
now owned or hereafter acquired. 
 Section 9.18 Entire Agreement. This Loan Agreement and each of the other Transaction Documents,
taken together, constitute and contain the entire agreement of Borrower, Agent and the Lenders and supersede any and all prior agreements, negotiations, correspondence, understandings and communications among the parties, whether written or oral,
respecting the subject matter hereof. 
 Article 10. DEFINITIONS. 
 All terms defined in the Code shall have the respective meanings specified in the Code. In addition, for purposes of this Loan Agreement the following capitalized terms shall have the meanings set forth below:

 “Advance” shall have the meaning set forth in Section 1.01 of this Loan Agreement. 
 “Advance Percentage” shall mean, with respect to a Lender, the percentage of each Advance specified opposite such Lender’s
name on Schedule 1 hereto. 
 “Affiliate” shall mean any Person that owns or controls directly or indirectly ten
percent (10%) or more of the stock of another entity, any Person that controls or is controlled by or is under common control with such Persons or any Affiliate of such Persons and each of such Person’s officers, directors, members, joint
venturers or partners. When used with respect to a Lender, Affiliate shall also include any Affiliate of Agent. 
 “Borrower’s Books” shall mean all of Borrower’s books and records including without limitation: ledgers; records concerning Borrower’s assets or liabilities, the Collateral, business operations or
financial condition; and all computer programs, or tape files, and the equipment, containing such information. 
 “Borrower’s
Primary Operating Account” shall have the meaning set forth in Section 5.05 of this Loan Agreement. 
 “Business
Day” shall mean any day on which commercial banks are not authorized or required to close in San Francisco, California. 
 “Closing” shall mean the date, time and place as the parties may agree for the execution of this Loan Agreement. 
 “Code” shall mean the Uniform Commercial Code as in effect from time to time in the state of California. 
 “Collateral” shall mean property described on Exhibit B attached hereto. 
 “Commitment” shall have the meaning set forth in Section 1.01 of this Loan Agreement. 
 “Contractual Obligation” of any Person shall mean, any indenture, note, security, deed of trust, mortgage, security agreement, lease, guaranty, instrument, contract, agreement or other form of obligation or
undertaking to which such Person is a party or by which such Person or any of its property is bound. 
  

 -18- 

 “Copyrights” shall mean any and all copyright rights, copyright applications,
copyright registrations and like protections in each work or authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held.

 “Default” shall mean any event or circumstance not yet constituting an Event of Default but which, with the giving
of any notice or the lapse of any period of time or both, would become an Event of Default. 
 “Default Rate” shall
mean, as of any date of determination, an interest rate per annum equal to five percent (5%) in excess of the rate per annum otherwise applicable on such date. 
 “Environmental Laws” shall mean all Requirements of Law relating to the protection of human health or the environment, including, without limitation, (i) all Requirements of Law,
pertaining to reporting, licensing, permitting, investigation, and remediation of emissions, discharges, releases, or threatened releases of hazardous materials, chemical substances, pollutants, contaminants, or hazardous or toxic substances,
materials or wastes whether solid, liquid, or gaseous in nature, into the air, surface water, groundwater, or land, or relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport, or handling of chemical
substances, pollutants, contaminants, or hazardous or toxic substances, materials, or wastes, whether solid, liquid, or gaseous in nature; and (ii) all Requirements of Law pertaining to the protection of the health and safety of employees or
the public. 
 “Equipment” shall mean all present and future machinery, equipment, tenant improvements, furniture,
fixtures, vehicles, tools, parts and attachments in which Borrower has any interest. 
 “Equity Securities” of any
Person shall mean (i) all common stock, preferred stock, participations, shares, partnership interests, membership interests or other equity interests in and of such Person (regardless of how designated and whether or not voting or non-voting)
and (ii) all warrants, options and other rights to acquire any of the foregoing. 
 “Event of Default” shall
have the meaning set forth in Article 7 of this Loan Agreement. 
 “Event of Loss” shall have the meaning set
forth in Section 5.11(a) of this Loan Agreement. 
 “Financial Statements” shall mean, with respect to any
accounting period for any Person, statements of operations, retained earnings and cash flow of such Person for such period, and balance sheets of such Person as of the end of such period, setting forth in each case in comparative form figures for
the corresponding period in the preceding fiscal year if such period is less than a full fiscal year or, if such period is a full fiscal year, corresponding figures from the preceding fiscal year, all prepared in reasonable detail and in accordance
with generally accepted accounting principles, except in the case of unaudited Financial Statements, for the absence of footnotes and normal year-end adjustments. Unless otherwise indicated, each reference to Financial Statements of any Person shall
be deemed to refer to Financial Statements prepared on a consolidated basis. 
 “Funding Date” shall mean any date on
which an Advance is made to or on account of Borrower under this Loan Agreement. 
 “Funding Termination Date” shall
have the meaning set forth in Section 1.01 of this Loan Agreement. 
 “Governmental Authority” shall mean any
domestic or foreign national, state or local government, any political subdivision thereof, any department, agency, authority or bureau of any of the foregoing, or any other entity exercising executive, legislative, judicial, regulatory or
administrative functions of or pertaining to government. 
  

 -19- 

 “Governmental Rule” shall mean any law, rule, regulation, ordinance, order, code
interpretation, judgment, decree, directive, guidelines, policy or similar form of decision of any Governmental Authority. 
 “Indebtedness” of any Person shall mean and include the aggregate amount of, without duplication (i) all obligations of such Person for borrowed money, (ii) all obligations of such Person evidenced by
bonds, debentures, notes or other similar instruments, (iii) all obligations of such Person to pay the deferred purchase price of property or services (other than accounts payable incurred in the ordinary course of business determined in
accordance with generally accepted accounting principles), (iv) all obligations under capital leases of such Person, (v) all obligations or liabilities of others secured by a lien on any asset of such Person, whether or not such obligation
or liability is assumed, (vi) all guaranties of such Person of the obligations of another Person, (vii) all obligations created or arising under any conditional sale or other title retention agreement with respect to property acquired by
such Person (even if the rights and remedies of the seller or lender under such agreement upon an event of default are limited to repossession or sale of such property), (viii) net exposure under any interest rate swap, currency swap, forward,
cap, floor or other similar contract that is not entered to in connection with a bona fide hedging operation that provides offsetting benefits to such Person, which agreements shall be marked to market on a current basis, and (ix) all
reimbursement and other payment obligations, contingent or otherwise, in respect of letters of credit. 
 “Intellectual
Property” shall mean: (i) Copyrights, Trademarks, Patents, and Mask Works; (ii) any and all trade secrets, and any and all intellectual property rights in computer software and computer software products now or
hereafter existing, created, acquired or held; (iii) any and all design rights which may be available to Borrower now or hereafter existing, created, acquired or held; (iv) any and all claims for damages by way of past, present and future
infringement of any of the rights included above, with the right, but not the obligation, to sue for and collect such damages for said use or infringement of the intellectual property rights identified above; (v) all licenses or other rights to
use any of the Copyrights, Patents, Trademarks, or Mask Works, and all license fees and royalties arising from such use; (vi) all amendments, renewals and extensions of any of the Copyrights, Trademarks, Patents or Mask Works; and
(vii) all proceeds and products of the foregoing, including without limitation all payments under insurance or any indemnity or warranty payable in respect of any of the foregoing. 
 “Inventory” shall mean all present and future inventory in which Borrower has any interest, including merchandise, raw materials,
parts, supplies, packing and shipping materials, work in process and finished products intended for sale or lease or to be furnished under a contract of service, of every kind and description now or at any time hereafter owned by or in the custody
or possession, actual or constructive, of Borrower, including such inventory as is temporarily out of its custody or possession or in transit and including any returns upon any accounts or other proceeds, including insurance proceeds, resulting from
the sale or disposition of any of the foregoing and any documents of title representing any of the above, and Borrower’s Books relating to any of the foregoing. 
 “Investment” shall mean the purchase or acquisition of any capital stock, equity interest, or any obligations or other securities of, or any interest in, any Person, or the extension of any
advance, loan, extension of credit or capital contribution to, or any other investment in, any Person. 
 “Lien”
shall mean, with respect to any property, any security interest, mortgage, pledge, lien, claim, charge or other encumbrance in, of, or on such property or the income therefrom, including, without limitation, the interest of a vendor or lessor under
a conditional sale agreement, capital lease or other title retention agreement, or any agreement to provide any of the foregoing, and the filing of any financing statement or similar instrument under the Code or comparable law of any jurisdiction.

 “Loan Agreement” shall mean this Loan and Security Agreement, as amended, restated or otherwise modified from time
to time. 
 “Management Rights Agreement” shall mean a management rights agreement entered into by Borrower and Agent
contemporaneously with the execution of this Loan Agreement. 
  

 -20- 

 “Mask Works” shall mean all mask works or similar rights available for the
protection of semiconductor chips, now owned or hereafter acquired. 
 “Material Adverse Effect” shall mean a
material adverse effect on (i) the business, assets, operations, or financial or other condition of Borrower and its Subsidiaries, taken as a whole; (ii) the ability of Borrower and its Subsidiaries to pay or perform the Obligations in
accordance with the terms of this Loan Agreement and the other Transaction Documents and to avoid an Event of Default under any Transaction Document; or (iii) the rights and remedies of any Lender under this Loan Agreement, the other
Transaction Documents or any related document, instrument or agreement. 
 “Note” shall mean a promissory note or
notes of Borrower substantially in the form attached as Exhibit A hereto. 
 “Obligations” shall mean and include all
loans, advances, debts, liabilities, and obligations, including, without limitation, the noncancelable obligation to make each payment scheduled to be made under Sections 1.02(b), 1.02(c) and 1.02(d), howsoever arising, owed by Borrower to Lenders
of every kind and description (whether or not evidenced by any note or instrument and whether or not for the payment of money), now existing or hereafter arising under or pursuant to the terms of this Loan Agreement or the other Transaction
Documents, including, without limitation, all interest, fees, charges, expenses, attorneys’ fees and costs and accountants’ fees and costs chargeable to and payable by Borrower hereunder and thereunder, in each case, whether direct or
indirect, absolute or contingent, due or to become due, and whether or not arising after the commencement of a proceeding under Title 11 of the United States Code (11 U.S.C. Section 101 et seq.), as amended from time to time (including
post-petition interest) and whether or not allowed or allowable as a claim in any such proceeding. 
 “Patents” shall
mean all patents, patent applications and like protections, including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 
 “Payment Date” shall have the meaning set forth in Section 1.02(b) of this Loan Agreement. 
 “Permitted Indebtedness” shall mean: (i) Indebtedness of Borrower in favor of Lenders arising under this Loan Agreement or
any other Transaction Document; (ii) Indebtedness existing at Closing and disclosed on Schedule 2; (iii) Indebtedness secured by a lien described in clause (vi)(A) of the defined term “Permitted Liens,” provided
(A) such Indebtedness does not exceed the lesser of the cost or fair market value of the equipment financed with such Indebtedness, (B) such Indebtedness does not exceed $100,000 in the aggregate at any given time, and (C) the holder
of such Indebtedness agrees to waive any rights of set off such holder may have with respect to such Indebtedness in the deposit or investment accounts of Borrower and its Subsidiaries on terms reasonably satisfactory to Agent;
(iv) Subordinated Debt; (v) Indebtedness incurred for the acquisition of supplies or inventory on normal trade credit; and (vi) extensions, refinancings, modifications, amendments and restatements of any item of Permitted Indebtedness
(i) through (v) above. 
 “Permitted Investments” shall mean: (i) Investments existing at
Closing disclosed on Schedule 2; (ii) (A) marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State thereof maturing within one (1) year from the date of
acquisition thereof, (B) commercial paper maturing no more than one (1) year from the date of creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s
Investors Service, Inc., and (C) certificates of deposit maturing no more than one (1) year from the date of investment therein; (iii) temporary advances to cover incidental expenses in the ordinary course of business;
(iv) investments in joint ventures, strategic alliances, licensing and similar arrangements customary in Borrower’s industry and which do not require Borrower to assume or otherwise become liable for the obligations of any third party not
directly related to or arising out of such arrangement or require Borrower to transfer ownership of non-cash assets to such joint venture or other entity; (v) Investments consisting of (A) travel advances, employee relocation loans and
other employee loans and advances in the ordinary course of business not to exceed $50,000 and (B) non-cash loans to employees, officers or directors relating to the purchase of equity 

  

 -21- 

 
securities of Borrower pursuant to employee stock purchase plans or arrangements approved by Borrower’s board of directors; (vi) Investments
(including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of
business; and (vii) Investments consisting of notes receivable or, prepaid royalties and other credit obligations to customers and suppliers who are not Affiliates, in the ordinary course of business. 
 “Permitted Liens” shall mean and include: (i) Liens in favor of Agent; (ii) Liens existing at Closing and disclosed on
Schedule 2; (iii) other Liens subordinated to the Liens in favor of Agent; (iv) Liens of carriers, warehousemen, mechanics, materialmen, vendors, and landlords incurred in the ordinary course of business for sums not overdue or
being contested in good faith, provided provision is made to the reasonable satisfaction of Agent for the eventual payment thereof if subsequently found payable; (v) leases or subleases and licenses or sublicenses granted in the ordinary course
of Borrower’s business; (vi) Liens (A) upon or in any Equipment which was acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for the purpose of
financing the acquisition of such Equipment, or (B) existing on such equipment at the time of its acquisition, provided that the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such equipment;
(vii) bankers’ liens, rights of setoff and similar Liens incurred on deposits made in the ordinary course of business; (viii) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default;
(ix) Liens for taxes or other Taxes not at the time delinquent or thereafter payable without penalty or being contested in good faith, provided provision is made to the reasonable satisfaction of Agent for the eventual payment thereof if
subsequently found payable; (x) Liens in favor of customs and revenue authorities arising as a matter of law to secure payments of customs duties in connection with the importation of goods; (xi) Liens on insurance proceeds in favor of
insurance companies granted solely as security for financed premiums; and (xii) Liens incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type described in clauses (i) through
(iii) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced does not increase.

 “Person” shall mean and include an individual, a partnership, a corporation (including a business trust), a joint
stock company, a limited liability company, an unincorporated association, a joint venture or other entity or a Governmental Authority. 
 “Prime Rate” shall mean the prime rate published in the Wall Street Journal dated as of the applicable Funding Date. 
 “Requirement of Law” applicable to any Person shall mean (i) the articles or certificate of incorporation, bylaws or other governing documents of such Person, (ii) any Governmental
Rule applicable to such Person, (iii) any license, permit, approval or other authorization granted by any Governmental Authority to or for the benefit of such Person and (iv) any judgment, decision or determination of any Governmental
Authority or arbitrator, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its property is subject. 
 “Subordinated Debt” shall mean any debt incurred by Borrower that is subordinated to the debt owing by Borrower to Lenders on terms acceptable to Lenders (and identified as being such by
Borrower and Lenders). 
 “Subsidiary” of any Person shall mean (i) any corporation of which more than fifty
percent (50%) of the issued and outstanding equity securities having ordinary voting power to elect a majority of the Board of Directors of such corporation (irrespective of whether at the time capital stock of any other class or classes of
such corporation shall or might have voting power upon the occurrence of any contingency) is at the time directly or indirectly owned or controlled by such Person, by such Person and one or more of its other Subsidiaries or by one or more of such
Person’s other Subsidiaries, (ii) any partnership, joint venture, or other association of which more than fifty percent (50%) of the equity interest having the power to vote, direct or 

  

 -22- 

 
control the management of such partnership, joint venture or other association is at the time owned and controlled by such Person, by such Person and one or
more of the other Subsidiaries or by one or more of such Person’s other subsidiaries and (iii) any other Person included in the financial statements of such Person on a consolidated basis. Any reference to a Subsidiary without designation
of the ownership of such Subsidiary shall be deemed to refer to a Subsidiary of Borrower. 
 “Tax” or
“Taxes” shall mean any present or future tax, levy, impost, duty, charge, fee, deduction or withholding of any nature and whatever called, by whomsoever, on whomsoever and wherever imposed, levied, collected,
withheld or assessed, including interest, penalties, additions to tax and any similar liabilities with respect thereto; except that, in the case of a Lender, there shall be excluded (i) taxes that are imposed on the overall net income or net
profits (including franchise taxes imposed in lieu thereof) (a) by the United States, (b) by any other Governmental Authority under the laws of which such Lender is organized or has its principal office or maintains its applicable lending
office, or (c) by any jurisdiction solely as a result of a present or former connection between such Lender and such jurisdiction (other than any such connection arising solely from such Lender having executed, delivered or performed its
obligations or received a payment under, or enforced, any of the Transaction Documents), and (ii) any branch profits taxes imposed by the United States or any similar tax imposed by any other jurisdiction in which such Lender is located.

 “Trademarks” shall mean any trademark and servicemark rights, whether registered or not, applications to register
and registrations of the same and like protections, and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks. 
 “Transaction Documents” shall mean, collectively, the Loan Agreement, the Notes, the Management Rights Agreement, the Warrant Purchase Agreement, the Warrants and the other documents executed
in connection herewith. 
 “Warrant” shall mean a warrant or warrants to purchase capital stock of the Borrower
issued by Borrower to an Affiliate of Lenders pursuant to a Warrant Purchase Agreement contemporaneously with the execution of this Loan Agreement. 
 “Warrant Purchase Agreement” shall mean a warrant purchase agreement under which a Warrant is issued entered into by Borrower and an Affiliate of Lenders contemporaneously with the execution of this Loan Agreement.

 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 
  

 -23- 

 IN WITNESS WHEREOF, the parties hereto have executed this Loan Agreement as of the date first written
above. 
  

									
	AGENT:	 		 	BORROWER:
			
	PINNACLE VENTURES, L.L.C.,	 		 	PHENOMIX CORPORATION,
	a Delaware limited liability company	 		 	a Delaware corporation

  

									
					
	By:	 	/s/ Robert N. Savoie	 		 	By:	 	/s/ Laura Shawver
			
	Name: Robert N. Savoie	 		 	Name: Laura Shawver, Ph.D.
			
	Title: Chief Financial Officer	 		 	Title: President & Chief Executive Officer

 LENDERS: 
 PINNACLE VENTURES II-A (SUB), L.P., 
 a Delaware limited partnership 
 PINNACLE VENTURES II-B, L.P., 
 a Delaware limited partnership 
 PINNACLE VENTURES II-C, L.P., 
 a Delaware limited partnership

 PINNACLE VENTURES II-R (SUB), L.P., 
 a Delaware limited
partnership 
  

			
		
	By:	 	 Pinnacle Ventures Management II, L.L.C.,
 their general
partner

		
	By:	 	/s/ Robert N. Savoie
		
	Name:	 	Robert N. Savoie
		
	Title:	 	Chief Financial Officer

  

 -24- 

 SCHEDULE 1 
  

			
	 Lender
	  	Advance Percentage
		
	PINNACLE VENTURES II-A (SUB), L.P.	  	2%
		
	PINNACLE VENTURES II-B, L.P.	  	84%
		
	PINNACLE VENTURES II-C, L.P.	  	7%
		
	PINNACLE VENTURES II-R (SUB), L.P.	  	7%

 SCHEDULE 2 
  

			
	Other Names:	  	none
		
	Deposit and Securities Accounts:	  	 Comerica Bank
 11943 El Camino Real
 San Diego, CA 92130
 Account
#            (General Checking)
 Account
#            (Money Market)

		
	Other Collateral Locations:	  	none
		
	 Existing Indebtedness:
	  	 Indebtedness to Comerica Bank under December 23, 2004 Loan and
 Security Agreement to be paid off immediately upon receipt of first
 advance under this Loan Agreement.

		
		  	 Indebtedness to Oxford Finance Corporation under March 24, 2006
 Master Security Agreement and related Promissory Notes

		
	Existing Investments:	  	(see Deposit and Securities Accounts above)
		
	Existing Liens:	  	 Lien on Collateral identified in Oxford Finance Corporation Collateral
 Schedules Nos. 1, 2 and 3.

 EXHIBIT A 
 Secured Promissory Note 
  

			
	$            	 	Dated:             

 FOR VALUE RECEIVED, the undersigned, PHENOMIX CORPORATION (“Borrower”), a Delaware
corporation, HEREBY PROMISES TO PAY to the order of Pinnacle Ventures, L.L.C. (“Agent”) for the account of the Lenders the principal amount of             Dollars
($            ) or such lesser amount as shall equal the aggregate outstanding principal balance of the Advance made by Agent on the date hereof to Borrower pursuant to the Loan
and Security Agreement referred to below (the “Loan Agreement”), plus all payments arising under Sections 1.02(b) (excluding the portion of the payments representing the original principal amount), 1.02(c) and 1.02(d) of the Loan Agreement
with respect to such Advance, on the dates and in the amounts set forth in the Loan Agreement. Capitalized terms used herein and not otherwise defined have the respective meanings set forth in the Loan Agreement. 
 Payments under this Note shall be made as follows: 
  

			
	Interim Payment on Funding Date:	  	$____________
		
	 6 monthly payments on the first Business
 Day of each
Month after the Funding Date
	  	$__________, commencing __________
		
	 Thereafter, 30 monthly payments on the first
 Business
Day of each Month after the
 Funding Date
	  	$__________, commencing ____________

 All other payments due under this Note or under the Loan Agreement shall be payable as and when
specified in the Loan Agreement. 
 This Note is one of the Notes referred to in, and is entitled to the benefits of, the Loan and Security
Agreement, dated as of November 22, 2006, between Borrower, Agent and the Lenders. This Note and the obligation of Borrower to repay the unpaid principal amount of the Advance, interest on the Advance, premium, if any, and all other amounts due
Agent and Lenders under the Loan Agreement is secured under the Loan Agreement. 
 Presentment for payment, demand, notice of protest and all
other demands and notices of any kind in connection with the execution, delivery, performance and enforcement of this Note are hereby waived. 
 Borrower shall pay all reasonable fees and expenses, including, without limitation, reasonable attorneys’ fees and costs, incurred by Agent or any Lender in the enforcement or attempt to enforce any of Borrower’s obligations
hereunder not performed when due. This Note shall be governed by, and construed and interpreted in accordance with, the laws of the State of California. 
  

 A-1 

 IN WITNESS WHEREOF, Borrower has caused this Note to be duly executed by one of its officers thereunto
duly authorized on the date hereof. 
  

			
	PHENOMIX CORPORATION,
	a Delaware corporation
		
	By:	 	 
		
	Name:	 	Laura Shawver, Ph.D.
		
	Title:	 	President & Chief Executive Officer

  

 A-2 

 EXHIBIT B 
 The Collateral shall consist of all right, title, interest, claims and demands of Borrower in and to the following: 
 (a) All goods and equipment now owned or hereafter acquired, including, without limitation, all laboratory equipment, computer equipment, office equipment, machinery, fixtures, vehicles, and any interest in any of the foregoing, and all
attachments, accessories, accessions, replacements, substitutions, additions, and improvements to any of the foregoing, wherever located; 
 (b) All inventory now owned or hereafter acquired, including, without limitation, all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products including such inventory as is
temporarily out of Borrower’s custody or possession or in transit and including any returns upon any accounts or other proceeds, including insurance proceeds, resulting from the sale or disposition of any of the foregoing and any documents of
title representing any of the above, and Borrower’s books relating to any of the foregoing; 
 (c) All contract rights, general
intangibles, health care insurance receivables, payment intangibles and commercial tort claims, now owned or hereafter acquired, including, without limitation, all patents, patent rights (and applications and registrations therefor), trademarks and
service marks (and applications and registrations therefor), inventions, copyrights, mask works (and applications and registrations therefor), trade names, trade styles, software and computer programs, trade secrets, methods, processes, know how,
drawings, specifications, descriptions, and all memoranda, notes, and records with respect to any research and development, goodwill, license agreements, franchise agreements, blueprints, drawings, purchase orders, customer lists, route lists,
infringements, claims, computer programs, computer disks, computer tapes, literature, reports, catalogs, design rights, income tax refunds, payments of insurance and rights to payment of any kind and whether in tangible or intangible form or
contained on magnetic media readable by machine together with all such magnetic media; 
 (d) All now existing and hereafter arising
accounts, contract rights, royalties, license rights and all other forms of obligations owing to Borrower arising out of the sale or lease of goods, the licensing of technology or the rendering of services by Borrower (subject, in each case, to the
contractual rights of third parties to require funds received by Borrower to be expended in a particular manner), whether or not earned by performance, and any and all credit insurance, guaranties, and other security therefor, as well as all
merchandise returned to or reclaimed by Borrower and Borrower’s books relating to any of the foregoing; 
 (e) All documents, cash,
deposit accounts letters of credit, letter of credit rights, supporting obligations, certificates of deposit, instruments, chattel paper, electronic chattel paper, tangible chattel paper and investment property, including, without limitation, all
securities, whether certificated or uncertificated, security entitlements, securities accounts, commodity contracts and commodity accounts, and all financial assets held in any securities account or otherwise, wherever located, now owned or
hereafter acquired and Borrower’s books relating to the foregoing; and 
 (f) Any and all claims, rights and interests in any of the
above and all substitutions for, additions and accessions to and proceeds thereof, including, without limitation, insurance, condemnation, requisition or similar payments and the proceeds thereof. 

 Notwithstanding the foregoing, the Collateral shall not be deemed to include any copyrights, copyright
applications, copyright registrations and like protection in each work of authorship and derivative work thereof, whether published or unpublished, now owned or hereafter acquired; any patents, patent applications and like protections including
without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same, trademarks, servicemarks and applications therefor, whether registered or not, and the goodwill of the business of
Borrower connected with and symbolized by such trademarks, any trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, license rights and agreements and confidential information, now owned or hereafter
acquired; or any claims for damage by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”), except that the Collateral shall include (A) the proceeds of all the
Intellectual Property that are accounts, (i.e. accounts receivable) of Borrower, or general intangibles consisting of rights to payment, and (B) if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the
underlying Intellectual Property is necessary to have a security interest in such accounts and general intangibles of Borrower that are proceeds of the Intellectual Property, then the Collateral shall automatically, and effective as of the date of
Closing, include the Intellectual Property to the extent necessary to permit perfection of Agent’s security interest in such accounts and general intangibles of Borrower that are proceeds of the Intellectual Property.

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