Document:

<PAGE>

                                                                     EXHIBIT 4.2

                              DATED           2005

                         OSI PHARMACEUTICALS, INC. (1)
                                      AND
                           'FIRST-NAME' 'SURNAME' (2)

        ---------------------------------------------------------------

                     DEED OF SHARE EXCHANGE RELATING TO THE
                          SHARES OF PROSIDION LIMITED
        ---------------------------------------------------------------
<PAGE>

                               TABLE OF CONTENTS

<Table>
<S>   <C>                                                           <C>
      Definitions and Interpretation..............................
1                                                                     1
      Exchange of Shares..........................................
2                                                                     2
      Representations.............................................
3                                                                     2
      Completion..................................................
4                                                                     4
      Further Assurance...........................................
5                                                                     5
      Invalidity..................................................
6                                                                     5
      Non-Assignment..............................................
7                                                                     5
      Notices.....................................................
8                                                                     5
      Third Party Rights..........................................
9                                                                     5
      Variation...................................................
10                                                                    6
      Waiver......................................................
11                                                                    6
      Entire Agreement............................................
12                                                                    6
      Counterparts................................................
13                                                                    6
      Governing Law...............................................
14                                                                    6
</Table>
<PAGE>

                             DEED OF SHARE EXCHANGE

THIS DEED is made the   day of           2005

BETWEEN:

     (1) OSI PHARMACEUTICALS, INC., a company incorporated under the laws of the
state of Delaware, USA and having its registered office at 58 South Service
Road, Melville, New York, 11747, USA (the "PARENT COMPANY"); and

     (2) 'First-Name' 'Surname' of 'Address-1', 'Address-2', 'Address-3',
'Address-4' 'Address-5' (the "MEMBER"),
each a "PARTY" and collectively the "PARTIES").

RECITALS:

     (A) WHEREAS Prosidion Limited was incorporated under the laws of England
and Wales on 25 November 2002 (registered number 4600121) and has an authorised
share capital of 2,000 Pound divided into 14,000,000 Preferred Ordinary Shares
of 0.0001 Pound each ("PREFERRED ORDINARY SHARES"); 4,000,000 A Ordinary Shares
of 0.0001 Pound each ("A ORDINARY SHARES"); and 2,000,000 B Ordinary Shares of
0.0001 Pound("B ORDINARY SHARES") each.

     (B) WHEREAS 'Shareholding' B Ordinary Shares (the "SHARES") have been
issued to the Member.

     (C) WHEREAS the Member is the legal and beneficial owner of the Shares.

     (D) WHEREAS the Parent Company has proposed to acquire all of the Shares
from the Member in exchange for common stock, par value $0.01 per share of the
Parent Company ("PARENT COMPANY STOCK").

     (E) WHEREAS the Member and the Parent Company have agreed to the exchange
of the Shares in return for the issue of Parent Company Stock on the terms and
conditions set out in this Deed.

     (F) WHEREAS, the offer and issuance of the Consideration Stock, as defined
below, by the Parent Company is made pursuant to Regulation D under the
Securities Act of 1933, as amended (the "SECURITIES ACT").

NOW IT IS AGREED AS FOLLOWS:

1  DEFINITIONS AND INTERPRETATION

     1.1 In this Deed, subject to any express contrary indication:

          (a) words importing the singular shall include the plural and vice
     versa;

          (b) any reference to this Deed or any other agreement or document
     shall be construed as a reference to that agreement or document as it may
     have been, or may from time to time be, amended, varied, novated, replaced
     or supplemented;

          (c) any reference to a statute or enactment shall be construed as a
     reference to such statute as it may have been, or may from time to time be,
     amended or re-enacted and any subordinate legislation made or thing done,
     or may from time to time be done, under the statute or enactment provided
     that, as between the parties, no such amendment or modification shall apply
     for the purposes of this Deed to the extent that it would impose any new or
     extended obligation, liability or restriction on, or otherwise adversely
     affect the rights of, any party; and

          (d) any reference to any English legal term for any action, remedy,
     method of judicial proceeding, legal document, legal status, court,
     official, or any legal concept or thing shall in respect

                                        1
<PAGE>

     of any jurisdiction (other than England) be deemed to include what most
     nearly approximates in that jurisdiction to the English legal term.

     1.2 All headings in this Deed are for ease of reference only and shall not
affect the interpretation of this Deed.

     1.3 Capitalised terms used in the Recitals and this Deed shall, unless the
context otherwise requires, have the meaning set out in the Articles of
Association of the Company.

2  EXCHANGE OF SHARES

     2.1 EXCHANGE RATIO

          For the purposes of this Deed the Parent Company and the Member agree
     that the Shares shall be exchanged for Parent Company Stock on the basis of
     the following exchange ratio (the "EXCHANGE RATIO"):

             For each Share: 0.29685 shares of Parent Company Stock

     2.2 NO FRACTIONAL SHARES

     No certificates representing fractional shares of the Parent Company Stock
shall be issued, and such fractional share interests will not entitle the Member
to vote or to any other rights of a stockholder of the Parent Company. With
respect to any fractional share interest to which the Member is entitled, the
Member shall be paid an amount in cash equal to the product obtained by
multiplying (i) such fractional share interest to which the Member would
otherwise be entitled by (ii) $53.90.

     2.3 EXCHANGE OF SHARES

     At Completion, in consideration for the Parent Company issuing to the
Member 'OSIP -- Shares shares of Parent Company Stock (the "CONSIDERATION
STOCK"), the Member as legal and beneficial owner shall transfer his Shares to
the Parent Company with full title guarantee free from any lien, claim, charge,
security interest, mortgage, pledge, easement, conditional sale or other title
retention agreement, defect in title, rights of third parties, restrictive
covenant or other restrictions of any kind (each an "ENCUMBRANCE").

3  REPRESENTATIONS AND COVENANTS

     3.1 The Member represents and warrants to the Parent Company at the date
hereof that:

          (a) he is the legal and beneficial owner of the Shares;

          (b) there is no Encumbrance on, over or affecting any of the Shares;

          (c) no agreement to create an Encumbrance has been entered into and no
     claim has been made by any person (natural or otherwise) that he is
     entitled to any such Encumbrance; and

          (d) he is duly authorized and has full power and authority to enter
     into and exercise his rights and perform his obligations under this Deed
     and all other documents to be executed by him at Completion; and

          (e) his obligations under this Deed are valid and binding subject to
     applicable law.

     3.2 In respect of U.S. securities laws, the Member represents and warrants
to the Parent Company at the date hereof that:

          (a) the Member is an "accredited investor" as defined in Regulation D
     under the Securities Act and is knowledgeable, sophisticated and
     experienced in making investments of the type contemplated by this Deed;

                                        2
<PAGE>

          (b) the Member is acquiring the Consideration Stock for his own
     account for investment only and with no present intention of distributing
     any of the Consideration Stock and has no arrangement or understanding with
     any other persons regarding the distribution of the Consideration Stock;

          (c) the Member (i) has been granted the opportunity to ask questions
     of, and receive answers from, representatives of the Parent Company
     concerning the terms and conditions of the exchange and (ii) has requested,
     received, reviewed and considered all information that he has deemed
     relevant in making an informed decision to acquire the Consideration Stock;

          (d) the Member has been advised of and understands the risks of an
     investment in the Consideration Stock;

          (e) the Member acknowledges that the acquisition of the Consideration
     Stock has not been registered under the Securities Act or registered or
     qualified under any U.S. state securities law in reliance on specific
     exemptions therefrom, which exemptions depend upon, among other things, the
     Members representations and covenants as expressed in this Deed;

          (f) the Member has been informed and understands that the
     Consideration Stock may not be sold except (i) pursuant to a registration
     statement, (ii) pursuant to an exemption from registration, or (iii) in
     compliance with Rule 144 of the Securities Act (and is therefore subject to
     the holding requirements of Rule 144 of the Securities Act);

          (g) the Member has no direct or indirect affiliation or association
     with any member of the National Association of Securities Dealers, Inc. in
     the United States (the "NASD").

          (h) The Member acknowledges that none of the Consideration Stock was
     offered or sold to him by means of any form of general solicitation or
     general advertising, and in connection therewith the Member did not (i)
     receive or review any advertisement, article, notice or other communication
     published in a newspaper or magazine or similar media or broadcast over
     television or radio, whether closed circuit or generally available; or (ii)
     attend any seminar, meeting or industry investor conference whose attendees
     were invited by any general solicitation or general advertising.

     3.3 In respect of U.S. securities laws, the Member covenants with the
Parent Company that:

          (a) The Member will not, directly or indirectly, offer, sell, pledge,
     transfer or otherwise dispose of or solicit any offers to buy any of the
     Consideration Stock except in compliance with the Securities Act and
     applicable state securities laws. In furtherance thereof, the Member will
     not make any disposition of the Consideration Stock except (i) pursuant to
     a registration statement under the Securities Act covering such proposed
     disposition, (ii) upon prior notice to the Parent Company and, if
     reasonably requested by the Parent Company, delivery to the Parent Company
     of an opinion of counsel, reasonably satisfactory to the Parent Company,
     that such disposition will not require registration under the Securities
     Act, or (iii) in compliance with Rule 144 under the Securities Act.

          (b) The Member understands that the Consideration Stock is
     characterized as "restricted securities" under the Securities Act inasmuch
     as they are being acquired from the Company in a transaction not involving
     a public offering and that under such law and applicable regulations such
     securities may be resold without registration under the Securities Act only
     in certain limited circumstances. The Member understands that certificates
     evidencing the Consideration Stock may bear one or all of the following
     legends:

             "The shares represented by this certificate have not been
        registered under the Securities Act of 1933, as amended (the "Act"), and
        may not be transferred without (i) an opinion of counsel satisfactory to
        the corporation that such transfer may lawfully be made without
        registration under such Act or qualification under applicable state
        securities laws; or (ii) such registration or qualification."

             If required by the authorities of any state in the United States in
        connection with the issuance of sale of the Consideration Stock, the
        legend required by such state authority.

                                        3
<PAGE>

          Any purchaser of the Consideration Stock pursuant to an effective
     registration statement under the Securities Act will be entitled to receive
     a certificate bearing no restrictive legend.

4  COMPLETION

     4.1 Completion shall take place at the offices of Prosidion Limited,
Watlington Road, Oxford, OX4 6LT on April 14, 2005 (the "COMPLETION"). At
Completion, the Member shall deliver to the Parent Company:

          (a) duly executed transfers of its Shares in favour of the Parent
     Company together with all share certificates relating to the Shares or, in
     the absence of which, an indemnity relating to loss of such share
     certificate; and

          (b) any other documents which may be required to vest in the Parent
     Company the full legal and beneficial ownership of the Shares and enable
     the Parent Company to procure them to be registered in its name or as it
     may direct.

     4.2 At Completion the Member IRREVOCABLY AND UNCONDITIONALLY APPOINTS the
Parent Company and each of Colin Goddard of 30 Allenby Drive, Fort Solonga, NY
11768, USA, Bob Van Nostrand of 15 Mariners Circle, West Islip, NY 11797, USA
and Barbara Wood of 200 West 90th Street, Apartment 12F, New York, NY 10024,
USA, each acting severally (each an "ATTORNEY") to be the true and lawful
Attorney of the Member, with full power to appoint substitutes, pending
registration of the Parent Company as the legal owner of the Shares and in
his/her name or otherwise on his/her behalf as the Attorney sees fit to execute
notices, instruments of proxy or other documents which may fall to be executed
or signed by the Member and exercise and perform any of the acts and things to
be done and performed by the Member in connection with the legal and beneficial
ownership of all or any of the Shares held by the Member as if the Attorney were
the legal and beneficial owner of such Shares and in particular but without
limitation the Attorney is appointed to:

          (a) attend any General Meeting (Annual and/or Extraordinary) of the
     Company and to represent the Member and vote on the Member's behalf and in
     his name;

          (b) exercise in the Member's name and on his/her behalf, all rights
     and privileges attached to his Shares including but not limited to the
     right to requisition the convening of an Extraordinary General Meeting;

          (c) to receive, in the Member's name and on his behalf, any notice or
     document which the Member is entitled to receive solely by virtue of being
     the registered holder of the Shares including the right to receive all
     benefits and entitlements which attach to the Shares from the date of
     Completion. For the avoidance of doubt this paragraph (c) does not cover
     Consideration Stock to be issued to the Member pursuant to his agreement
     with the Parent Company relating to the exchange of the Shares; and

          (d) execute and do (or procure the execution and giving of) such
     documents, acts and things as in the opinion of the Attorney is desirable
     and in such manner as the Attorney thinks fit as if the Attorney were the
     absolute legal and beneficial owner thereof.

     4.3 The power of attorney granted in Clause 4.2 shall expire on the date on
which the Parent Company is registered as the holder of the Shares in the
register of members of the Company.

     4.4 The Member undertakes to ratify everything which the Attorney shall do
or purport to do in good faith by virtue of the powers granted by the power of
attorney granted in Clause 4.2.

     4.5 Within seven days of the Parent Company receiving the documents
referred to in Clause 4.1 from the Member, it shall issue the Consideration
Stock to the Member and shall procure that the Member is registered as a
stockholder in the Parent Company in respect of his/its Consideration Stock.

          (a) If the Member fails or refuses to accept delivery of Consideration
     Stock then it shall be set aside by the Parent Company. Such setting aside
     shall be deemed, for all purposes of this Clause 4,

                                        4
<PAGE>

     to be a payment to the Member and all the Member's rights as a member of
     the Company shall cease as from the Completion Date and the Parent Company
     shall be discharged, on such setting aside, from all obligations in respect
     of the same. The Parent Company shall not be responsible for the safe
     custody of the Consideration Stock so set aside (which shall be held by the
     Parent Company for a maximum period of 12 years, after which period the
     Parent Company shall be entitled to cancel the Consideration Stock in
     full).

          (b) A receipt by the Member of stock certificates relating to his
     Consideration Stock due on exchange of his Shares shall constitute an
     absolute discharge to the Parent Company for all its obligations relating
     thereto.

     4.6 The Parent Company undertakes to file with U.S. Securities and Exchange
Commission a registration statement with respect to the resale of the Parent
Company Stock and have such registration statement declared effective according
to the terms set forth in Annex A to this Deed.

5  FURTHER ASSURANCE

     Each Member shall, at the expense of the Parent Company, do or procure to
be done all such further acts and things and execute or procure the execution of
all such other documents as the Parent Company may from time to time reasonably
require for the purpose of giving to the Parent Company the full benefit of all
the provisions of this Deed.

6  INVALIDITY

     If any provision of this Deed is held to be invalid or unenforceable, then
such provision shall (so far as it is invalid or unenforceable) be given no
effect and shall be deemed not to be included in this Deed but without
invalidating any of the remaining provisions of this Deed. The parties shall
then use all reasonable endeavours to replace the invalid or unenforceable
provision by a valid provision the effect of which is as close as possible to
the intended effect of the invalid or unenforceable provision.

7  NON-ASSIGNMENT

     No party shall, without the consent of the others, be entitled to assign
the benefit or burden of this Deed in whole or in part with the exception of the
assignment rights set forth in Annex A to this Deed.

8  NOTICES

     8.1 Any notice to be given under this Deed shall be in writing and shall be
delivered personally or sent by pre-paid international courier to the addressee
at the address set out on the face of this Deed or such other address as may be
notified from time to time. A notice so addressed shall be deemed to have been
received:

          (a) if personally delivered, at the time of delivery; and

          (b) if sent by international courier, two days after the date of
     delivery of the notice to the international courier by the sender.

     8.2 For the avoidance of doubt, notice given under this Deed shall not be
validly served if sent by electronic mail.

9  THIRD PARTY RIGHTS

     The parties do not intend that any term of this Deed shall be enforceable
pursuant to the Contracts (Rights of Third Parties) Act 1999 by any person who
is not a party to this Deed.

                                        5
<PAGE>

10  VARIATION

     No variation of any of the terms of this Deed (or of any other documents
referred to herein) shall be valid unless it is in writing and signed by or on
behalf of each of the parties hereto. The expression "variation" shall include
any variation, supplement, deletion or replacement however effected.

11  WAIVER

     11.1 Any delay by the parties in exercising, or failure to exercise, any
right or remedy under this Deed shall not constitute a waiver of the right or
remedy or a waiver of any other rights or remedies and no single or partial
exercise of any rights or remedy under this Deed or otherwise shall prevent any
further exercise of the right or remedy or the exercise of any other right or
remedy.

     11.2 The rights and remedies of the parties under this Deed are cumulative
and not exclusive of any rights or remedies provided by law.

12  ENTIRE AGREEMENT

     This Deed, together with documents described in or expressed to be entered
into in connection with this Deed, constitutes the entire agreement between the
parties with respect to all matters referred to herein and supersede all prior
written or oral discussions, representations, negotiations and agreements among
them regarding such subject matter. Each party confirms that the terms of this
Deed are fair and reasonable.

13  COUNTERPARTS

     This Deed may be executed in as many counterparts (including facsimile
counterparts) as may be required. It shall not be necessary that the signatures
of, or on behalf of, each party, or that the signatures of all persons required
to bind any party, appear on each counterpart; but it shall be sufficient that
the signature of, or on behalf of, each party, or that the signatures of the
persons required to bind any party, appear on one or more of the counterparts.
All counterparts shall collectively constitute a single Deed. It shall not be
necessary in making proof of this Deed to produce or account for more than a
number of counterparts containing the respective signatures of, or on behalf of,
all of the parties hereto.

14  GOVERNING LAW

     14.1 This Deed shall be governed by and construed in accordance with the
laws of England and Wales.

     14.2 In relation to any legal action or proceedings arising out of or in
connection with this Deed ("PROCEEDINGS"), each of the parties irrevocably
submits to the non-exclusive jurisdiction of the English courts and waives any
objection to Proceedings in such courts on the grounds of venue or on the
grounds that Proceedings have been brought in an inappropriate forum.

                                        6
<PAGE>

     IN WITNESS WHEREOF the parties hereto have duly executed this agreement as
a deed with the intent that it is delivered as such on the day and year first
above written.

<Table>
<S>                                       <C>
EXECUTED AS A DEED                        )
BY                                        )
OSI PHARMACEUTICALS, INC.                 )
ACTING BY A DULY AUTHORISED               )
REPRESENTATIVE AND IN ACCORDANCE          )
WITH THE LAWS OF THE JURISDICTION OF      )
ITS INCORPORATION AND ARTICLES OF         )
ASSOCIATION/BY-LAWS                       )
                                          )
</Table>

                                          --------------------------------------

<Table>
<S>                                       <C>
EXECUTED AS A DEED                        )
BY                                        )
'FIRST-NAME' 'SURNAME'                    )
ACTING BY A DULY AUTHORISED               )
REPRESENTATIVE AND IN ACCORDANCE          )
WITH THE LAWS OF THE JURISDICTION OF      )
ITS INCORPORATION AND ARTICLES OF         )
ASSOCIATION/BY-LAWS                       )
                                          )
</Table>

                                          --------------------------------------

                                        7
<PAGE>

                                   ANNEX "A"

                  TERMS AND CONDITIONS FOR RESALE REGISTRATION

1  DEFINITIONS.

     In addition to those terms defined in the agreement, for the purposes of
this Annex A, the following terms shall have the meanings set forth here:

     1.1 "Affiliate" shall mean, with respect to any Person, any other Person
which directly or indirectly controls, is controlled by, or is under common
control with, such Person.

     1.2 "Closing Date" shall mean the date of Completion.

     1.3 "Common Stock" shall mean the Parent Company Stock as defined in
Recital D of the Deed.

     1.4 "Company" shall mean the Parent Company as defined in the preamble of
the Deed.

     1.5 "Exchange Act" shall mean the Securities Exchange Act of 1934, as
amended, and the rules and regulations promulgated thereunder.

     1.6 "Investor" shall mean the Member as defined in the preamble of the
Deed.

     1.7 "Nasdaq National Market" shall mean The Nasdaq Stock Market, Inc.
National Market.

     1.8 "Person" shall mean an individual, corporation, partnership, trust,
business trust, association, joint stock company, joint venture, pool,
syndicate, sole proprietorship, unincorporated organization, governmental
authority or any other form of entity not specifically listed herein.

     1.9 "Registration Statement" shall mean a registration statement filed
pursuant to Section 2.1(a) of this Annex A.

     1.10 "SEC" shall mean the United States Securities and Exchange Commission.

     1.11 "Shares" shall mean the Consideration Stock as defined in Clause 2.1
of the Deed.

     1.12 "Suspension" shall have the meaning set forth in Section 2.2(c) of
this Annex A.

     1.13 "Suspension Notice" shall have the meaning set forth in Section 2.2(c)
of this Annex A.

2  REGISTRATION OF THE SHARES; COMPLIANCE WITH THE SECURITIES ACT.

     2.1 Registration Procedures and Expenses. The Company shall:

          (a) subject to prompt receipt of necessary information from the
     Investor after prompt request from the Company to the Investor to provide
     such information, use commercially reasonable efforts to prepare and file
     with the SEC, as soon as practicable after the Closing Date of the
     transactions contemplated in the Deed, a shelf registration statement (the
     "Registration Statement") to enable the resale of the Shares by the
     Investor from time to time on a delayed or continuous basis pursuant to
     Rule 415 of the Securities Act through the automated quotation system of
     the Nasdaq National Market or such other market as may be the principal
     market on which the Company's Common Stock is sold, or any other manner
     reasonably requested by the Investor, including privately-negotiated
     transactions;

          (b) use commercially reasonable efforts, subject to receipt of
     necessary information from the Investor after prompt request from the
     Company to the Investor to provide such information, to cause the
     Registration Statement to become effective as soon as practicable after the
     Registration Statement is filed by the Company;

          (c) use commercially reasonable efforts to prepare and file with the
     SEC such amendments and supplements to the Registration Statement and the
     prospectus used in connection therewith as may be necessary to keep the
     Registration Statement current and effective until the later of (i) two
     years

                                        8
<PAGE>

     after the Closing Date or (ii) the date on which all of the Shares may be
     sold pursuant to Rule 144 of the Securities Act without regard to any
     volume limitations;

          (d) furnish to the Investor such number of copies of the Registration
     Statement, prospectuses and preliminary prospectuses in conformity with the
     requirements of the Securities Act and such other documents as the Investor
     may reasonably request, in order to facilitate the public sale or other
     disposition of all or any of the Shares by the Investor; provided, however,
     that the obligation of the Company to deliver copies of prospectuses or
     preliminary prospectuses to the Investor shall be subject to the receipt by
     the Company of reasonable assurances from the Investor that the Investor
     will comply with the applicable provisions of the Securities Act and of
     such other securities or blue sky laws as may be applicable in connection
     with any use of such prospectuses or preliminary prospectuses;

          (e) take all reasonable actions necessary to ensure that the Shares
     are listed and available for quotation on The Nasdaq National Market;

          (f) file documents required of the Company for normal blue sky
     clearance in states specified in writing by the Investor; provided,
     however, that the Company shall not be required to qualify to do business
     or consent to service of process in any jurisdiction in which it is not now
     so qualified or has not so consented;

          (g) bear all expenses in connection with the procedures in paragraph
     (a) through (f) of this Section 2.1 and the registration of the Shares
     pursuant to the Registration Statement; and

          (h) advise the Investor promptly after it shall receive notice or
     obtain knowledge of the issuance of any stop order by the SEC delaying or
     suspending the effectiveness of the Registration Statement or of the
     initiation or threat of any proceeding for that purpose; and it will
     promptly use commercially reasonable efforts to prevent the issuance of any
     stop order or to obtain its withdrawal at the earliest possible moment if
     such stop order should be issued.

     The Company understands that the Investor disclaims being an underwriter,
but any determination by the SEC that the Investor is an underwriter shall not
relieve the Company of any obligations it has hereunder.

     2.2 Transfer of Shares After Registration; Suspension.

          (a) The Investor hereby agrees that it will not effect any disposition
     of the Shares that would constitute a sale within the meaning of the
     Securities Act except as contemplated in the Registration Statement
     referred to in Section 2.1 and as described below or as otherwise permitted
     by law, and that it will promptly notify the Company of any changes in the
     information set forth in the Registration Statement regarding the Investor
     or its plan of distribution.

          (b) Except in the event that paragraph (c) below applies, the Company
     shall (i) if deemed necessary by the Company, prepare and file from time to
     time with the SEC a post-effective amendment to the Registration Statement
     or a supplement to the related prospectus or a supplement or amendment to
     any document incorporated therein by reference or file any other required
     document so that such Registration Statement will not contain an untrue
     statement of a material fact or omit to state a material fact required to
     be stated therein or necessary to make the statements therein not
     misleading, and so that, as thereafter delivered to purchasers of the
     Shares being sold thereunder, such prospectus will not contain an untrue
     statement of a material fact or omit to state a material fact required to
     be stated therein or necessary to make the statements therein, in light of
     the circumstances under which they were made, not misleading; (ii) provide
     the Investor copies of any documents filed pursuant to this Section
     2.2(b)(i); and (iii) inform the Investor that the Company has complied with
     its obligations in this Section 2.2(b)(i) (or that, if the Company has
     filed a post-effective amendment to the Registration Statement which has
     not yet been declared effective, the Company will notify the Investor to
     that effect, will use commercially reasonable efforts to secure the

                                        9
<PAGE>

     effectiveness of such post-effective amendment as promptly as possible and
     will promptly notify the Investor pursuant to this Section 2.2(b)(i) when
     the amendment has become effective).

          (c) Subject to paragraph (d) below, in the event (i) of any request by
     the SEC or any other federal or state governmental authority during the
     period of effectiveness of the Registration Statement for amendments or
     supplements to a Registration Statement or related prospectus or for
     additional information; (ii) of the issuance by the SEC or any other
     federal or state governmental authority of any stop order suspending the
     effectiveness of a Registration Statement or the initiation of any
     proceedings for that purpose; (iii) of the receipt by the Company of any
     notification with respect to the suspension of the qualification or
     exemption from qualification of any of the Shares for sale in any
     jurisdiction or the initiation or threatening of any proceeding for such
     purpose; or (iv) of any event or circumstance which, upon the advice of its
     counsel, necessitates the making of any changes in the Registration
     Statement or prospectus, or any document incorporated or deemed to be
     incorporated therein by reference, so that, in the case of the Registration
     Statement, it will not contain any untrue statement of a material fact or
     any omission to state a material fact required to be stated therein or
     necessary to make the statements therein not misleading, and that in the
     case of the prospectus, it will not contain any untrue statement of a
     material fact or any omission to state a material fact required to be
     stated therein or necessary to make the statements therein, in the light of
     the circumstances under which they were made, not misleading; then the
     Company shall promptly deliver a certificate in writing to the Investor
     (the "Suspension Notice") to the effect of the foregoing and, upon receipt
     of such Suspension Notice, the Investor will refrain from selling any
     Shares pursuant to the Registration Statement (a "Suspension") until it
     receives copies of a supplemented or amended prospectus prepared and filed
     by the Company, or until it is advised in writing by the Company that the
     current prospectus may be used, and has received copies of any additional
     or supplemental filings that are incorporated or deemed incorporated by
     reference in any such prospectus. In the event of any Suspension, the
     Company will use its commercially reasonable efforts to cause the use of
     the prospectus so suspended to be resumed as soon as reasonably
     practicable.

          (d) Provided that a Suspension is not then in effect, the Investor may
     sell the Shares under the Registration Statement; provided, however, that
     it arranges for delivery of a current prospectus to the transferee of such
     Shares. Upon receipt of a request therefor, the Company has agreed to
     provide an adequate number of current prospectuses to the Investor and to
     supply copies to any other parties requiring such prospectuses.

          (e) In the event of a sale of the Shares by the Investor pursuant to
     the Registration Statement, the Investor must also deliver to the Company's
     transfer agent, with a copy to the Company, a Certificate of Subsequent
     Sale substantially in the form attached hereto as Exhibit A so that the
     Shares may be properly transferred. Assuming timely delivery to the
     Company's transfer agent of one or more stock certificates representing the
     Shares in proper form for transfer and assuming compliance by the Investor
     with the terms of this Deed, the Company's transfer agent will issue and
     make appropriate delivery of one or more stock certificates in the name of
     the buyer so as to permit timely compliance by the Investor with applicable
     settlement requirements.

     2.3 Indemnification.

          (a) Definitions. For the purpose of this Section 2.3:

             (i) the term "Selling Stockholder" shall include the Investor and
        each person, if any, who controls the Investor within the meaning of
        Section 15 of the Securities Act, including any officer, director,
        trustee or Affiliate of the Investor;

             (ii) the term "Registration Statement" shall include any final
        prospectus, exhibit, supplement or amendment included in or relating to
        the Registration Statement referred to in Section 2.1; and

             (iii) the term "untrue statement" shall include any untrue
        statement or alleged untrue statement, or any omission or alleged
        omission to state in the Registration Statement a material

                                        10
<PAGE>

        fact required to be stated therein or necessary to make the statements
        therein, in the light of the circumstances under which they were made,
        not misleading.

          (b) Indemnification by the Company. To the extent permitted by law,
     the Company agrees to indemnify and hold harmless the Selling Stockholder
     from and against any losses, claims, damages or liabilities to which such
     Selling Stockholder may become subject (under the Securities Act or
     otherwise) insofar as such losses, claims, damages or liabilities (or
     actions or proceedings in respect thereof) arise out of, or are based upon,
     (i) any untrue statement of a material fact contained in the Registration
     Statement, or (ii) any failure by the Company to fulfill any undertaking
     included in the Registration Statement, and the Company will reimburse such
     Selling Stockholder for any reasonable legal or other expenses reasonably
     incurred in investigating, defending or preparing to defend any such
     action, proceeding or claim; provided, however, that the Company shall not
     be liable in any such case to the extent that such loss, claim, damage or
     liability arises out of, or is based upon, an untrue statement made in such
     Registration Statement in reliance upon and in conformity with written
     information furnished to the Company by or on behalf of the Selling
     Stockholder specifically for use in preparation of the Registration
     Statement or the failure of the Selling Stockholder to comply with its
     covenants and agreements contained in the Deed respecting the sale of the
     Shares or any statement or omission in any prospectus that is corrected in
     any subsequent prospectus that was delivered to the Investor prior to the
     pertinent sale or sales by the Investor; provided however,that the Selling
     Stockholder shall be entitled to be indemnified in any such case for any
     statement or alleged statement in or omission or alleged omission from such
     Registration Statement, preliminary prospectus, final prospectus or summary
     prospectus contained therein, or any amendment or supplement thereto, in
     which such statement or omission has been corrected, in writing, by the
     Investor and delivered to the Company at least ten (10) days before the
     sale or sales from which such loss occurred. The Company shall reimburse
     the Selling Stockholder for the amounts provided for herein upon receipt of
     written demand providing evidence of such expenses.

          (c) Indemnification by the Investor. To the extent permitted by law,
     the Investor agrees to indemnify and hold harmless the Company (and each
     person, if any, who controls the Company within the meaning of Section 15
     of the Securities Act, each officer of the Company who signs the
     Registration Statement and each director of the Company) and all other
     selling stockholders listed in the Registration Statement from and against
     any losses, claims, damages or liabilities to which the Company (or any
     such officer, director or controlling person) may become subject (under the
     Securities Act or otherwise), insofar as such losses, claims, damages or
     liabilities (or actions or proceedings in respect thereof) arise out of, or
     are based upon, (i) any failure to comply with the covenants and agreements
     contained in this Deed respecting the sale of the Shares, or (ii) any
     untrue statement of a material fact contained in the Registration Statement
     if such untrue statement was made in reliance upon and in conformity with
     written information furnished by or on behalf of the Investor specifically
     for use in preparation of the Registration Statement, and the Investor will
     reimburse the Company (or such officer, director or controlling person), as
     the case may be, for any reasonable legal or other expenses reasonably
     incurred in investigating, defending or preparing to defend any such
     action, proceeding or claim; provided however, that the Selling Stockholder
     shall have no obligation to indemnify the Company in any such case for any
     statement or alleged statement in or omission or alleged omission from such
     Registration Statement, preliminary prospectus, final prospectus or summary
     prospectus contained therein, or any amendment or supplement thereto, in
     which such statement or omission has been corrected, in writing, by the
     Investor and delivered to the Company at least ten (10) days before the
     sale or sales from which such loss occurred. The Investor shall reimburse
     the Company and the other selling stockholders listed in the Registration
     Statement for the amounts provided for herein upon receipt of written
     demand providing evidence of such expenses.

          (d) Notice of Claims, Etc. Promptly after receipt by any indemnified
     person of a notice of a claim or the beginning of any action in respect of
     which indemnity is to be sought against an indemnifying person pursuant to
     this Section 2.3, such indemnified person shall notify the

                                        11
<PAGE>

     indemnifying person in writing of such claim or of the commencement of such
     action, but the omission to so notify the indemnifying party will not
     relieve it from any liability which it may have to any indemnified party
     under this Section 2.3 (except to the extent that such omission materially
     and adversely affects the indemnifying party's ability to defend such
     action) or from any liability otherwise than under this Section 2.3.
     Subject to the provisions hereinafter stated, in case any such action shall
     be brought against an indemnified person, the indemnifying person shall be
     entitled to participate therein, and, to the extent that it shall elect by
     written notice delivered to the indemnified party promptly after receiving
     the aforesaid notice from such indemnified party, shall be entitled to
     assume the defense thereof, with counsel reasonably satisfactory to such
     indemnified person. After notice from the indemnifying person to such
     indemnified person of its election to assume the defense thereof, such
     indemnifying person shall not be liable to such indemnified person for any
     legal expenses subsequently incurred by such indemnified person in
     connection with the defense thereof; provided, however, that if there
     exists or shall exist a conflict of interest that would make it
     inappropriate, in the opinion of counsel to the indemnified person, for the
     same counsel to represent both the indemnified person and such indemnifying
     person or any Affiliate or associate thereof, the indemnified person shall
     be entitled to retain its own counsel at the expense of such indemnifying
     person; provided, however, that no indemnifying person shall be responsible
     for the fees and expenses of more than one separate counsel (together with
     appropriate local counsel) for all indemnified parties. In no event shall
     any indemnifying person be liable in respect of any amounts paid in
     settlement of any action unless the indemnifying person shall have approved
     the terms of such settlement; provided, however, that such consent shall
     not be unreasonably withheld. No indemnifying person shall, without the
     prior written consent of the indemnified person, effect any settlement of
     any pending or threatened proceeding in respect of which any indemnified
     person is or could have been a party and indemnification could have been
     sought hereunder by such indemnified person, unless such settlement
     includes an unconditional release of such indemnified person from all
     liability on claims that are the subject matter of such proceeding.

          (e) Contribution. If the indemnification provided for in this Section
     2.3 is unavailable to or insufficient to hold harmless an indemnified party
     under paragraph (b) or (c) above in respect of any losses, claims, damages
     or liabilities (or actions or proceedings in respect thereof) referred to
     therein, then each indemnifying party shall contribute to the amount paid
     or payable by such indemnified party as a result of such losses, claims,
     damages or liabilities (or actions in respect thereof) in such proportion
     as is appropriate to reflect the relative fault of the Company on the one
     hand and the Investor, as well as any other selling stockholder under the
     Registration Statement, on the other in connection with the statements or
     omissions or other matters which resulted in such losses, claims, damages
     or liabilities (or actions in respect thereof), as well as any other
     relevant equitable considerations. The relative fault shall be determined
     by reference to, among other things, in the case of an untrue statement,
     whether the untrue statement relates to information supplied by the Company
     on the one hand or an Investor or other selling stockholder on the other
     and the parties' relative intent, knowledge, access to information and
     opportunity to correct or prevent such untrue statement. The Company and
     the Investor agree that it would not be just and equitable if contribution
     pursuant to this paragraph (e) were determined by pro rata allocation (even
     if the Investor and other selling stockholders were treated as one entity
     for such purpose) or by any other method of allocation which does not take
     into account the equitable considerations referred to above in this
     paragraph (e). The amount paid or payable by an indemnified party as a
     result of the losses, claims, damages or liabilities (or actions in respect
     thereof) referred to above in this paragraph (e) shall be deemed to include
     any legal or other expenses reasonably incurred by such indemnified party
     in connection with investigating or defending any such action or claim. No
     person guilty of fraudulent misrepresentation (within the meaning of
     Section 11(f) of the Securities Act) shall be entitled to contribution from
     any person who was not guilty of such fraudulent misrepresentation.

          (f) Survival. The obligations of the Company and the Investor under
     this Section 2.3 shall survive the completion of any offering of Shares in
     a Registration Statement.

                                        12
<PAGE>

3  RULE 144.

     The Company covenants that it will file the reports required to be filed by
it under the Securities Act and the Exchange Act and the rules and regulations
adopted by the SEC thereunder (or, if the Company is not required to file such
reports, it will, upon the request of the Investor, make publicly available such
information as necessary to permit sales pursuant to Rule 144 under the
Securities Act), and it will take such further action as the Investor may
reasonably request, all to the extent required from time to time to enable the
Investor to sell the shares purchased hereunder without registration under the
Securities Act within the limitation of the exemptions provided by (a) Rule 144
under the Securities Act, as such rule may be amended from time to time, or (b)
any similar rule or regulation hereafter adopted by the SEC. Upon the request of
the Investor, the Company will deliver to it a written statement as to whether
the Company has complied with such information and requirements.

4  SUCCESSORS AND ASSIGNS.

     The rights set forth in this Annex A may not be assigned by the Investor.
Without the necessity of the prior written consent of the Investor, but after
notice duly given and in compliance with Clause 8 of the Deed, the Company may
assign its rights and delegate its duties hereunder to any successor-in-interest
corporation in the event of a merger or consolidation of the Company with or
into another corporation, or any merger or consolidation of another corporation
with or into the Company that results directly or indirectly in an aggregate
change in the ownership or control of more than 50% of the voting rights of the
equity securities of the company, or the sale of all or substantially all of the
Company's assets. The terms and conditions of this Annex shall inure to the
benefit of and be binding upon the respective permitted successors and assigns
of the parties. Nothing in this Annex A, express or implied, is intended to
confer upon any party other than the parties hereto or their respective
successors and assigns any rights, remedies, obligations, or liabilities under
or by reason of this Annex A, except as expressly provided in this Annex A.

                                        13
<PAGE>

                                   EXHIBIT A

                         CERTIFICATE OF SUBSEQUENT SALE

Bank of New York
101 Barclay Street
New York, NY 10286

     RE: Sale of Shares of Common Stock of OSI Pharmaceuticals, Inc. (the
         "Company") pursuant to the Company's Prospectus dated           ,
         (the "Prospectus")

Dear Sir/Madam:

     The undersigned hereby certifies, in connection with the sale of shares of
Common Stock of the Company included in the table of Selling Stockholders in the
Prospectus, that the undersigned has sold the shares pursuant to the Prospectus
and in a manner described under the caption "Plan of Distribution" in the
Prospectus and that such sale complies with all applicable securities laws,
applicable to the undersigned, including, without limitation, the Prospectus
delivery requirements of the Securities Act of 1933, as amended.

Selling Stockholder (the beneficial owner):
-------------------------------------------------------------------

Record Holder (e.g., if held in name of nominee):
-----------------------------------------------------------

Restricted Stock Certificate No.(s):
---------------------------------------------------------------------------

Number of Shares Sold:
--------------------------------------------------------------------------------

Date of Sale:
--------------------------------------------------------------------------------

     In the event that you receive a stock certificate(s) representing more
shares of Common Stock than have been sold by the undersigned, then you should
return to the undersigned a newly issued certificate for such excess shares in
the name of the Record Holder and BEARING A RESTRICTIVE LEGEND. Further, you
should place a stop transfer on your records with regard to such certificate.

<Table>
<S>                                             <C>
                                                Very truly yours,

Dated:
--------------------------------------------..  By:
                                                --------------------------------------------
                                                Print Name:
                                                ----------------------------------------
                                                Title:
                                                --------------------------------------------
</Table>

cc:  Robert L. Van Nostrand
     Vice President and Chief Financial Officer
     OSI Pharmaceuticals, Inc.
     58 South Service Road, Suite 110
     Melville, NY 11747

                                        14exv10w1

 

Exhibit 10.1

McAfee, Inc.

Executive Officer Annual Compensation for Fiscal Year Ending December 31, 2005

	 	 	 	 	 	 	 	 	 
	Name	 	Expected Annual Salary ($)*	 	 	Incentive Bonus Potential ($)	 
	George Samenuk
	 	 	850,000	 	 	 	1,250,000	 
	Gene Hodges
	 	 	525,000	 	 	 	550,000	 
	Eric Brown
	 	 	500,000	**	 	 	500,000	**
	Kevin Weiss
	 	 	497,994	 	 	 	497,994	 
	Kent Roberts
	 	 	370,000	 	 	 	222,000	 

* In addition certain members of management will be entitled to additional forms of compensation,
such as company paid insurance premiums. Consistent with past practice, George Samenuk will also
be entitled to personal use of a corporate aircraft in which the Registrant owns a fractional
interest; compensation associated with the personal use of aircraft amounted to $45,727 for the
fiscal year ended 2004.

** As previously reported on Form 8-K filed with the Commission on December 14, 2004.

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