Document:

exv10w4

Exhibit 10.4

EXECUTION COPY

 

PURCHASE OPTION AGREEMENT

by and among

OXiGENE, INC.

SYMPHONY ViDA HOLDINGS LLC

and

SYMPHONY ViDA, INC.

 

Dated as of October 1, 2008

 

 

 

 

TABLE OF CONTENTS

	 	 	 	 	 
	 	 	Page
	Section 1. Grant of Purchase Option
	 	 	2	 
	 
	 	 	 	 
	Section 2. Exercise of Purchase Option
	 	 	3	 
	 
	 	 	 	 
	Section 3. Company Representations, Warranties and Covenants
	 	 	9	 
	 
	 	 	 	 
	Section 4. Holdings Representations, Warranties and Covenants
	 	 	12	 
	 
	 	 	 	 
	Section 5. Symphony Collaboration Representations, Warranties and Covenants
	 	 	16	 
	 
	 	 	 	 
	Section 6. Notice of Material Event
	 	 	24	 
	 
	 	 	 	 
	Section 7. Assignment; Transfers; Legend
	 	 	25	 
	 
	 	 	 	 
	Section 8. Costs and Expenses; Payments
	 	 	26	 
	 
	 	 	 	 
	Section 9. Expiration; Termination of Agreement
	 	 	26	 
	 
	 	 	 	 
	Section 10. Survival; Indemnification
	 	 	26	 
	 
	 	 	 	 
	Section 11. No Petition
	 	 	30	 
	 
	 	 	 	 
	Section 12. Third-Party Beneficiary
	 	 	30	 
	 
	 	 	 	 
	Section 13. Notices
	 	 	30	 
	 
	 	 	 	 
	Section 14. Governing Law; Consent to Jurisdiction and Service of Process
	 	 	31	 
	 
	 	 	 	 
	Section 15. Waiver of Jury Trial
	 	 	32	 
	 
	 	 	 	 
	Section 16. Entire Agreement
	 	 	32	 
	 
	 	 	 	 
	Section 17. Amendment; Successors; Counterparts
	 	 	32	 
	 
	 	 	 	 
	Section 18. Specific Performance
	 	 	32	 
	 
	 	 	 	 
	Section 19. Severability
	 	 	32	 
	 
	 	 	 	 
	Section 20. Tax Reporting
	 	 	33	 

 

 

Annex A Certain Definitions

Annex B Form of Convertible Note

Exhibit 1 Purchase Exercise Notice

ii

 

PURCHASE OPTION AGREEMENT

     This PURCHASE OPTION AGREEMENT (this “Agreement”) is entered into as of October 1,
2008 (the “Closing Date”), by and among OXiGENE, INC., a Delaware corporation (the
“Company”), SYMPHONY ViDA HOLDINGS LLC, a Delaware limited liability company
(“Holdings”), and SYMPHONY ViDA, INC., a Delaware corporation (the “Symphony
Collaboration”). Capitalized terms used herein and not defined herein shall have the meanings
assigned to such terms in Annex A attached hereto.

PRELIMINARY STATEMENT

     WHEREAS, the Company and Holdings have entered into a Technology License Agreement pursuant to
which the Company has granted Holdings an exclusive license (the “License”) to the use of
certain intellectual property related to the Programs owned or controlled by the Company;

     WHEREAS, contemporaneously with the execution of this Agreement, the Company, Holdings and the
Symphony Collaboration are entering into a Novated and Restated Technology License Agreement,
pursuant to which, among other things, Holdings will assign by way of novation the License to the
Symphony Collaboration;

     WHEREAS, the Company and Holdings have entered into a Research and Development Agreement
pursuant to which Holdings and the Company have agreed to develop the Programs and to establish a
Development Committee to oversee such development;

     WHEREAS, contemporaneously with the execution of this Agreement, the Company, Holdings and the
Symphony Collaboration are entering into an Amended and Restated Research and Development
Agreement, pursuant to which, among other things, Holdings will assign its rights and obligations
under the Research and Development Agreement to the Symphony Collaboration;

     WHEREAS, contemporaneously with the execution of this Agreement, in order to fund such
research and development, institutional investors are committing to invest up to $40,000,000 in
Holdings (the “Financing”) in exchange for (i) membership interests in Holdings, (ii)
shares of the Company Common Stock having a market value of up to $15,000,000 issued to Holdings
(the “Direct Investment Shares”), (iii) a warrant to purchase Company Common Stock issued
to Holdings (the “Warrant Shares”) having a market value of up to $15,000,000 less the
value of the Direct Investment Shares (the “Direct Investment Warrant”), (iv) shares of the
Company Common Stock having a market value of $4,000,000 (the “Option Premium Shares”), and
(v) other consideration as contemplated by the terms of the Additional Funding Agreement, and
Holdings will agree to contribute $15,000,000 of the proceeds of the Financing to the Symphony
Collaboration and pay $15,000,000 of the proceeds of the Financing to the Company;

     WHEREAS, Holdings desires, in consideration for the foregoing, to grant the Company an option
to purchase all of the Common Stock of the Symphony Collaboration and any other Equity Securities
issued by the Symphony Collaboration (together, the

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“Symphony Collaboration Equity Securities”) owned, or hereinafter acquired, by
Holdings on the terms described in this Agreement;

     WHEREAS, the Company, Holdings, Investors and the Symphony Collaboration have entered into the
Additional Funding Agreement in furtherance of the transactions contemplated hereby and in the
other Operative Documents; and

     WHEREAS, the Company, the Symphony Collaboration and Holdings have determined that it is in
each of its best interest to perform and comply with certain agreements and covenants relating to
each of its ongoing operations contained in this Agreement.

     NOW, THEREFORE, in consideration of the foregoing and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto
(the “Parties”) agree as follows:

          Section 1. Grant of Purchase Option.

               (a) Holdings hereby grants to the Company an exclusive irrevocable option (the “Purchase
Option”) to purchase all, but not less than all, of the outstanding Symphony Collaboration
Equity Securities owned or hereinafter acquired by Holdings, in accordance with the terms of this
Agreement.

               (b) The Symphony Collaboration hereby covenants and agrees that all Symphony Collaboration
Equity Securities issued by the Symphony Collaboration at any time prior to the expiration of the
Term (including to Holdings, on, prior to, or after the date hereof or to any other Person at any
time whatsoever, in all cases prior to the expiration of the Term) shall be subject to the Purchase
Option and all of the other terms and conditions of this Agreement without any additional action on
the part of the Company or Holdings. For the avoidance of doubt, to the extent the Symphony
Collaboration shall issue any Symphony Collaboration Equity Securities (including any issuance in
respect of a transfer of Symphony Collaboration Equity Securities by any holder thereof, including
Holdings) after the date hereof to any Person (including Holdings) (any issuance of such Symphony
Collaboration Equity Securities being subject to the prior written consent of the Company as set
forth in Sections 5(c) and 7(b) hereof, as applicable), the Symphony Collaboration
hereby covenants and agrees that it shall cause such Symphony Collaboration Equity Securities to be
subject to the Purchase Option without the payment of, or any obligation to pay, any additional
consideration in respect of such Symphony Collaboration Equity Securities by the Company, the
Symphony Collaboration or any Symphony Collaboration Subsidiary to the Person(s) acquiring such
subsequently issued Symphony Collaboration Equity Securities, the Parties acknowledging and
agreeing that the sole consideration payable by the Company pursuant to this Agreement for all of
the outstanding Symphony Collaboration Equity Securities now or hereinafter owned by any Person
shall be the Purchase Price (as defined in Section 2(b) hereof).

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               (c) The Company’s right to exercise the Purchase Option granted hereby is subject to the
following conditions:

                    (i) The Purchase Option may only be exercised for the purchase of all, and not less than all,
of the Symphony Collaboration Equity Securities;

                    (ii) The Purchase Option may only be exercised a single time;

                    (iii) Except as expressly provided in Section 1(c)(iv), the Purchase Option may be
exercised only during the period (the “Purchase Option Period”) commencing on and including
the first day following the first anniversary of the Closing Date (the “Purchase Option
Commencement Date”) and ending on and including the earliest of (x) March 31, 2012 (the
“Final Termination Date”), (y) the 40th calendar day (such 40th calendar day, the
“Funds Termination Date”) immediately following the date (the “Balance Sheet Deficiency
Date”) on which a notice that an impending Funds Termination Date may occur as a result of such
Balance Sheet Deficiency Date (the “Funds Termination Notice”) is delivered to the Company
by Holdings or the Symphony Collaboration in accordance with Section 13 hereof, accompanied
by an internally prepared, unaudited balance sheet of the Symphony Collaboration (prepared in
accordance with GAAP (except for the absence of footnotes)) stating that the working capital of the
Symphony Collaboration is less than the Balance Sheet Deficiency Threshold at such time (the
“Balance Sheet Deficiency”); provided, that, notwithstanding the foregoing to the
contrary, if the Additional Holdings Funding, a contribution by the Company pursuant to the
Optional Company Funding or the Company Payment Amount shall have been paid to the Symphony
Collaboration, the Funds Termination Date shall be the 30th calendar day immediately following the
next occurrence of a Balance Sheet Deficiency Date, and (z) the date on which both Programs have
been discontinued pursuant to Section 4.2(c) of the Amended and Restated Research and
Development Agreement.

                    (iv) In the event that the Symphony Collaboration terminates the Amended and Restated Research
and Development Agreement pursuant to Section 17.2 thereof, the Company shall have five (5)
Business Days to notify Holdings of its exercise of the Purchase Option under the terms of this
Agreement.

          Section 2. Exercise of Purchase Option.

               (a) Exercise Notice. The Company may exercise the Purchase Option only by delivery of
a notice in the form attached hereto as Exhibit 1 (the “Purchase Option Exercise
Notice”) during the Purchase Option Period. The Purchase Option Exercise Notice shall be
delivered on a Business Day to Holdings and the Symphony Collaboration and shall be irrevocable
once delivered. The date on which the Purchase Option Exercise Notice is first delivered to
Holdings and the Symphony Collaboration is referred to as the “Purchase Option Exercise
Date.” The Purchase
Option Exercise Notice shall contain (1) an estimated date for the settlement of the Purchase
Option (the “Purchase Option Closing”), which date shall be estimated in

3

 

accordance with
this Section 2(a), (2) the Purchase Price, determined in accordance with
Section 2(b) hereof, and (3) if the Company intends to pay part of the Purchase Price in
Company Common Stock pursuant to a convertible note, the form of which is attached hereto as
Annex B (the “Convertible Note”), notice of such intent, the estimated number of
shares to be transferred at such purchase price, the estimated valuation thereof and the percentage
such portion bears to (A) the Purchase Price, and (B) the total amount of the Company Common Stock
then issued and outstanding (which shall be no greater percentages than are permitted under
Section 2(c)). If, during the period following the delivery of the Purchase Option
Exercise Notice, the working capital held by the Symphony Collaboration is less than or equal to
the Balance Sheet Deficiency Threshold, then the Symphony Collaboration shall cease payment of any
amounts owed to the Company in respect of its activities pursuant to the Amended and Restated
Research and Development Agreement, but shall continue to pay amounts owed to all other Persons.
All cash and cash equivalents on the Symphony Collaboration’s balance sheet on the date of the
Purchase Option Closing (the “Purchase Option Closing Date”) will not be transferred or
distributed to Holdings and shall be retained by the Symphony Collaboration. The Purchase Option
Closing Date shall be as follows:

                    (i) If the Company elects to pay the entire Purchase Price in cash, the Purchase Option
Closing Date shall be the date that is the later of: (A) five (5) Business Days following the
Purchase Option Exercise Date; and (B) five (5) Business Days following the date that the Company
receives all necessary Government Approvals related to its HSR Filings; provided,
however that unless Holdings receives from the Company an opinion from nationally
recognized anti-trust counsel (which opinion is acceptable in form and substance to Holdings) to
the effect that no HSR Filings are required, the Company and Holdings shall make all necessary HSR
Filings within ten (10) Business Days following the Purchase Option Exercise Date and shall
promptly and diligently pursue the related regulatory process, including without limitation,
responding to any second request from the Federal Trade Commission or the Department of Justice, as
applicable; and provided, further, that (1) if there is no second request from the
Federal Trade Commission or the Department of Justice, as applicable, with respect to the Company’s
or Holdings’ HSR Filings, then in no event shall the Purchase Option Closing Date be more than
sixty (60) days following the Purchase Option Exercise Date, and (2) if there is a second request
from the Federal Trade Commission or the Department of Justice, as applicable, with respect to the
Company’s or Holdings’ HSR Filings, then in no event shall the Purchase Option Closing Date be more
than one hundred and twenty (120) days following the date upon which the later of the Company or
Holdings delivers documents pursuant to such second request. If the Company shall fail to make
such cash payment on the Purchase Option Closing Date within the applicable time period set forth
above, then in addition to any other rights that Holdings shall have hereunder, this Agreement
shall terminate and the Company shall relinquish all rights hereunder to purchase Symphony
Collaboration Equity Securities; or

                    (ii) If the Company elects to pay a portion of the Purchase Price in Company Common Stock
pursuant to the Convertible Note (subject to
the limitations set forth herein and in the Registration Rights Agreement), the Purchase
Option Closing Date shall be the date that is the latest of:

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                    (A) five (5) Business Days following the Purchase Option Exercise Date;

                    (B) five (5) Business Days following the Effective Registration Date of such Company
Common Stock; provided, that Company shall file the Registration Statement
contemplated by Section 3(b)(i) within (x) ten (10) Business Days after the
Purchase Option Exercise Date if the Company is eligible to use Form S-3 under the
Securities Act (or any successor form), or (y) twenty (20) Business Days after the Purchase
Option Exercise Date if the Company is not eligible to use Form S-3 under the Securities
Act (or any successor form), unless otherwise agreed;

                    (C) five (5) Business Days following the date that the Company receives the necessary
Government Approvals related to its HSR Filings (if any) related to the exercise of the
Purchase Option; provided, however, that the Company and Holdings shall make all necessary
HSR Filings within five (5) Business Days following the Purchase Option Exercise Date and
shall promptly and diligently pursue the related regulatory process consistent with the
provisos in clause (i) above; and

                    (D) the maturity date set forth in the Convertible Note.

provided, further, that the Company shall use commercially reasonable efforts to
have such Registration Statement declared effective by the SEC as promptly as possible following
the filing of the Registration Statement. The Company shall use commercially reasonable efforts to
maintain the effectiveness of any such Registration Statement for a period of two (2) years
following the SEC’s declaration. Subject to the last sentence of this clause (a), in the event
that such Registration Statement is not declared effective within one hundred and twenty (120) days
following the Purchase Option Exercise Date (such period, the “Declaration Period”), the
Company shall pay the full Purchase Price in cash within five (5) Business Days (in which event the
Purchase Option Closing Date shall be the date upon which such cash payment within five (5)
Business Days is made by the Company). If the Company shall fail to make such cash payment, then
in addition to any other rights or remedies that Holdings shall have arising from such breach, this
Agreement shall terminate and the Company shall relinquish all rights hereunder to purchase the
Symphony Collaboration Equity Securities. The Declaration Period shall be extended for a
reasonable period of time as determined by the Symphony Collaboration Board in consultation with
recognized securities counsel in the event that any member of the Investors takes action with
respect to the Company Common Stock that prevents the Registration Statement from being declared
effective during the Declaration Period.

               (b) Purchase Price Upon Option Exercise. Upon exercise of the Purchase Option and as
complete and full consideration for the sale to the Company
by Holdings of its Symphony Collaboration Equity Securities (and for Symphony Collaboration
Equity Securities of any other Person), the Company shall pay (i) two (2) times the aggregate
amount of the Initial Investors Funding and the Additional Holdings

5

 

Funding, minus (ii) (x) the
aggregate amount of all Discontinuation Prices and other amounts paid by the Company directly to
Holdings or to the Symphony Collaboration pursuant to Section 11(a) of the Amended and
Restated Research and Development Agreement and the aggregate amount of all Discontinued Funds, in
each case as subsequently dividended or otherwise distributed to Holdings (if any), (y) any amount
paid by the Company for Symphony Collaboration Equity Securities of any other Person and (z) 50% of
the purchase price paid in consideration for any Non-IV Shares (the “Purchase Price”).

               (c) Form of Payment. Subject to Sections 2(a) and 2(e), the Purchase
Price may be paid in either cash or a combination of cash and the Convertible Note, at the sole
discretion of the Company; provided, that, in no event may the value of Company Common
Stock (determined in accordance with Section 2(e) hereof) delivered pursuant to the
Convertible Note in connection with the exercise of the Purchase Option constitute more than (i)
20% of the total Purchase Price or (ii) 10% of the total Company Common Stock outstanding
immediately prior to the time of the Purchase Option Exercise Date; provided
further, that, if the Company elects to pay the Purchase Price in a combination of cash and
the Convertible Note, the cash portion must be paid in accordance with Section 2(a)(i);
provided, however, that unless otherwise agreed by the Parties, the payment of a
portion of the Purchase Price in Company Common Stock pursuant to the Convertible Note shall be
subject to the receipt of any necessary stockholder approval for the purposes of the NASDAQ
Marketplace Rules 4350(i)(1)(B) and 4350(i)(1)(D); and further, in the sole discretion of Holdings,
shall not be permitted if such payment would or would be reasonably likely to result in any
liability to the Investors or their Affiliates under Section 16 of the Securities Exchange Act of
1934, as amended, as a result of any transaction entered into by the Investors or any of their
Affiliates prior to the issuance of such shares of Company Common Stock.

               (d) Surrender of Symphony Collaboration Equity Securities; Symphony Collaboration
Board. Subject to the terms and conditions of this Agreement, on the Purchase Option Closing
Date, Holdings shall surrender to the Company its certificates representing its Symphony
Collaboration Equity Securities, and shall convey good title to such Symphony Collaboration Equity
Securities, free from any Encumbrances and from any and all restrictions that any sale, assignment
or other transfer of such Symphony Collaboration Equity Securities be consented to or approved by
any Person. On or prior to the Purchase Option Closing Date, Holdings shall remove all directors
serving on the Symphony Collaboration Board, other than the Company Director (as defined in
Section 4(b)(v) hereof), as of the Purchase Option Closing Date.

               (e) Valuation of Company Stock. In the event that the Company elects to pay part of
the Purchase Price through the delivery to Holdings of Company Common Stock, the value per share
thereof (the “Company Common Stock Valuation”) shall equal the average closing price of
Company Common Stock, as reported by the NASDAQ Global Market, or other national exchange that is
the primary
exchange on which Company Common Stock is then listed, for the thirty (30) trading days
immediately preceding (but not including) the second trading day prior to the Purchase Option
Closing Date. If Company Common Stock is not then traded on a

6

 

national exchange or the NASDAQ
Global Market, unless otherwise agreed by the Parties, then the Company shall be obligated to pay
the Purchase Price solely in cash on the Purchase Option Closing Date. The Company shall calculate
the Company Common Stock Valuation in accordance with this Section 2(e), subject to review
and confirmation by Holdings.

               (f) Share Certificates. Any stock certificate(s) issued by the Company for Company
Common Stock pursuant to this Section 2 may contain a legend (the “33 Act Legend”)
substantially as follows:

THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, OR UNDER THE SECURITIES LAWS OF ANY STATE, AND
THE SAME HAVE BEEN ISSUED IN RELIANCE ON EXEMPTIONS FROM THE REGISTRATION
REQUIREMENTS OF SAID ACT AND SUCH LAWS. SUCH SHARES MAY NOT BE SOLD, TRANSFERRED,
PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT AS PERMITTED UNDER SUCH
SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.

This legend shall be removed by the Company, subject to, and in accordance with, the terms of
Section 3(b)(iii) hereof.

               (g) Government Approvals. On or prior to the Purchase Option Closing Date, each of
the Company, the Symphony Collaboration and Holdings shall have taken all necessary action to cause
all Governmental Approvals with respect to such Party (including, without limitation, the preparing
and filing of any pre-merger notification and report forms required under the HSR Filings required
to be in effect in connection with the transactions contemplated by this Agreement to be in effect;
provided, however, that with respect to Government Approvals required by a
Governmental Authority other than the United States federal government and its various branches and
agencies, the Parties’ obligations under this Section 2(g) shall be limited to causing to
be in effect only those Government Approvals, the failure of which to be in effect would, either
individually or in the aggregate, reasonably be expected to have a Material Adverse Effect on any
of the Parties. Each of the Symphony Collaboration and the Company shall pay its own costs
associated with taking such action. The Symphony Collaboration shall pay any costs of Holdings
associated with obtaining Government Approvals required in connection with the exercise of the
Purchase Option. All other costs and expenses of Holdings shall be paid by Holdings pursuant to
Section 8(b) hereof, including any costs arising from any error in Holdings’ initial
valuation of its investment in the Symphony Collaboration.

               (h) Transfer of Title. Transfer of title to the Company of all of the Symphony
Collaboration Equity Securities shall be deemed to occur automatically on the Purchase Option
Closing Date, subject to the payment by the Company on such date

7

 

of the Purchase Price and its
performance of its other obligations herein required to be performed under Section 2(e) and
(f), and under the Registration Rights Agreement, as applicable, on or prior to the
Purchase Option Closing Date to the reasonable satisfaction of Holdings, and thereafter the
Symphony Collaboration shall treat the Company as the sole holder of all Symphony Collaboration
Equity Securities, notwithstanding any failure of Holdings to tender certificates representing such
shares to the Company in accordance with Section 2(d) hereof. After the Purchase Option
Closing Date, Holdings shall have no rights in connection with such Symphony Collaboration Equity
Securities other than the right to receive the Purchase Price; provided, however,
that nothing in this Section 2(h) shall affect the survivability of any indemnification
provision in this Agreement upon termination of this Agreement.

               (i) Consents and Authorizations. On or prior to the Purchase Option Closing Date, the
Company shall have obtained all consents and authorizations necessary from stockholders and/or its
board of directors for the consummation of the exercise and closing of the Purchase Option, as may
be required under the organizational documents of the Company, any prior stockholders or board
resolution, any stock exchange or similar rules or any applicable law.

     Section 2A. Change of Control; Put Option.

               (a) In the event that a Change of Control of the Company occurs, the Company shall, and as
applicable, shall cause the Surviving Entity to, (i) subject to the terms of the Confidentiality
Agreement and any confidentiality agreement entered into in connection with a Change of Control,
provide notice to Holdings of a Change of Control no more than ten (10) days after the execution of
a definitive agreement committing the Company to a Change of Control, and in any event, no less
than ten (10) days prior to the closing of such Change of Control transaction, (ii) promptly
following any Change of Control, if the Company is not the Surviving Entity, the Surviving Entity
shall execute and deliver to the Symphony Collaboration and Holdings instruments, in form and
substance reasonably acceptable to the Symphony Collaboration and Holdings, whereby the Surviving
Entity expressly assumes all of the obligations of the Company hereunder and under each other
Operative Document to which the Company is a party, and (iii) ensure that all material applications
and filings have been made to, and all material consents have been received from, the FDA, and any
applicable foreign equivalent thereof, necessary for the Surviving Entity to satisfy all of its
material obligations under the Operative Documents, except to the extent that failure to make such
applications or filings or receive such consents would not reasonably be expected to have a
material adverse effect on the Programs or the Symphony Collaboration’s rights under the Operative
Documents.

               (b) Holdings shall have an exclusive option (the “Change of Control Put Option”) to
sell 100% of the Symphony Collaboration Equity Securities to the Surviving Entity, which may be
exercised within 30 days following a Change of Control, but in any event prior to the expiration of
the Term, in its sole discretion following a Change of Control with respect to the Company.

8

 

               (c) Holdings may exercise the Change of Control Put Option only by delivery of written notice
(the “Change of Control Put Option Exercise Notice”) during the Purchase Option Period.
The Change of Control Put Option Exercise Notice shall be delivered on a Business Day to the
Surviving Entity and the Symphony Collaboration, and shall thereafter be deemed for all purposes
under the terms of this Agreement to be a Purchase Option Exercise Notice by the Surviving Entity
(in accordance with the provisions of Section 2 hereof) as of the date such notice is
delivered (such date to be deemed for all purposes under the terms of this Agreement as the
Purchase Option Exercise Date). The Purchase Price with respect to such an exercise of the Change
of Control Put Option shall be the Purchase Price applicable under Section 2(b) hereof,
payable solely in cash. In the event Holdings exercises the Change of Control Put Option and such
sale is consummated, Holdings shall maintain and does not release any rights or claims against the
Surviving Entity, including rights or claims whereby Holdings is otherwise entitled to
reimbursement or indemnification under any of the Operative Documents or any other document
delivered by the Surviving Entity in connection with such Change of Control.

          Section 3. Company Representations, Warranties and Covenants.

               (a) As of the date hereof, the Company hereby represents and warrants, and, except to the
extent that any of the following representations and warranties are limited to the date of this
Agreement or otherwise limited, on the Purchase Option Closing Date, shall be deemed to have
represented and warranted, to Holdings and the Symphony Collaboration that:

                    (i) Organization. The Company is a corporation, duly organized, validly existing and
in good standing under the laws of the State of Delaware.

                    (ii) Authority and Validity. The Company has all requisite corporate power and
authority to execute, deliver and perform its obligations under this Agreement and to consummate
the transactions contemplated hereby. The execution, delivery and performance by the Company of
this Agreement and the consummation of the transactions contemplated hereby have been duly and
validly authorized by all necessary action required on the part of the Company, and no other
proceedings on the part of the Company are necessary to authorize this Agreement or for the Company
to perform its obligations under this Agreement. This Agreement constitutes the lawful, valid and
legally binding obligation of the Company, enforceable in accordance with its terms, except as the
same may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar
laws affecting the
enforcement of creditors’ rights generally and general equitable principles regardless of
whether such enforceability is considered in a proceeding at law or in equity.

                    (iii) No Violation or Conflict. The execution, delivery and performance of this
Agreement and the transactions contemplated hereby do not (A) violate, conflict with or result in
the breach of any provision of the Organizational Documents of the Company, (B) as of the date of
this Agreement, and as of the Purchase Option Closing Date if the Company elects to pay part of the
Purchase Price through the

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delivery of Company Common Stock (a “Partial Stock Payment”),
conflict with or violate any law or Governmental Order applicable to the Company or any of its
assets, properties or businesses, or (C) conflict with, result in any breach of, constitute a
default (or event that with the giving of notice or lapse of time, or both, would become a default)
under, require any consent under, or give to others any rights of termination, amendment,
acceleration, suspension, revocation or cancellation of, or result in the creation of any
Encumbrance on any of the assets or properties of the Company, pursuant to, any note, bond,
mortgage or indenture, contract, agreement, lease, sublease, license, permit, franchise or other
instrument or arrangement to which the Company is a party except, in the case of clauses
(B) and (C), to the extent that such conflicts, breaches, defaults or other matters
would not, individually or in the aggregate, reasonably be expected to have a Material Adverse
Effect on the Company.

                    (iv) Governmental Consents and Approvals. Other than any HSR Filings which, if the
Purchase Option is exercised by the Company and if such HSR Filings are required pursuant to
Section 2(a) hereof, will be obtained on or prior to the Purchase Option Closing Date, the
execution, delivery and performance of this Agreement by the Company do not, and the consummation
of the transactions contemplated hereby do not and will not, require any Governmental Approval
which has not already been obtained, effected or provided, except with respect to which the failure
to so obtain, effect or provide would not, individually or in the aggregate, reasonably be expected
to have a Material Adverse Effect on the Company.

                    (v) Litigation. As of (A) the date of this Agreement, except as disclosed in any
Company Public Filings available as of the date hereof, and (B) the Purchase Option Closing Date if
the Company elects to make a Partial Stock Payment, there are no actions by or against the Company
pending before any Governmental Authority or, to the knowledge of the Company, threatened to be
brought by or before any Governmental Authority, that would, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect on the Company. There are no pending or,
to the knowledge of the Company, threatened actions, to which the Company is a party (or is
threatened to be named as a party) to set aside, restrain, enjoin or prevent the execution,
delivery or performance of this Agreement or the Operative Documents or the consummation of the
transactions contemplated hereby or thereby by any party hereto or thereto. As of the date of this
Agreement, and as of the Purchase Option Closing Date if the Company elects to make a Partial Stock
Payment, the Company is not subject to any Governmental Order (nor, to the knowledge of the
Company, is there any such Governmental Order threatened to be imposed by any Governmental
Authority) that
would, individually or in the aggregate, reasonably be expected to have a Material Adverse
Effect on the Company.

                    (vi) Information. All information provided or otherwise made available by the Company
or its representatives in connection with the Programs and the underlying intellectual property,
this Agreement, the Operative Documents and the transactions contemplated thereby, when taken as a
whole, is complete and correct in all material respects and does not contain any untrue statement
of material fact or, to the Company’s Knowledge, omit to state a material fact necessary to make
the statements

10

 

contained therein, in light of the circumstances under which such statements are
made, not misleading.

                    (vii) Option Premium Shares. The Company will treat the Option Premium Shares, with a
value of $4,000,000, and the Additional Investment Shares, with a value of up to $1,000,000, for
federal, state and local income tax purposes as an option premium paid in return for the grant of
the Purchase Option and the Additional Holdings Funding, as applicable.

               (b) The Company hereby covenants and agrees with Holdings as follows:

                    (i) Immediately prior to the Purchase Option Closing Date, the Company shall have sufficient
amounts of cash and, if applicable, sufficient authorized but unissued, freely transferable and
nonassessable Company Common Stock available, to satisfy the portion of the Purchase Price to be
paid in cash or Company Common Stock pursuant to and to the extent permitted by
Sections 2(b) and 2(c); provided, that if the Purchase Option Closing Date
does not occur within (A) five (5) Business Days if no HSR Filings are required or (B) thirty (30)
days if HSR Filings are required, in each case following the Purchase Option Exercise Date and
pursuant to Section 2(a) hereof, the Company shall provide Holdings with evidence of the
Company’s wherewithal to pay, or firm commitments from third parties with the wherewithal to pay,
or other guaranty of payment, in each case which is reasonably acceptable to Holdings, for that
portion of the Purchase Price to be paid in cash. In the event that the Company elects to satisfy
any portion of the Purchase Price in Company Common Stock (A) the Company shall have, not later
than the Purchase Option Closing Date, unless otherwise agreed, a Registration Statement
declared effective by the Securities and Exchange Commission for the resale of any such shares of
Company Common Stock to be delivered in partial satisfaction of the Purchase Price, accompanied by
evidence reasonably acceptable to Holdings that such Company Common Stock has been approved for
listing on the NASDAQ Global Market or such other national market on which the Company Common Stock
is then listed, and (B) the Company shall deliver to Holdings on or before the Purchase Option
Closing Date, a legal opinion from the Company’s legal counsel, Mintz, Levin, Cohn, Ferris, Glovsky
and Popeo, P.C., or such other counsel as the Company and Holdings shall mutually agree, which
opinion shall be, in form and substance, reasonably acceptable to Holdings and shall contain, with
respect to the Company Common Stock to be used as partial payment of the Purchase Price,
substantially the same opinions rendered by Mintz, Levin, Cohn, Ferris, Glovsky and
Popeo, P.C., in paragraphs 4, 5 and 7 of the opinion delivered to Holdings on the Closing
Date, along with customary assumptions and limitations. 

                    (ii) If the Company elects to satisfy any portion of the Purchase Price in Company Common
Stock, the Company, on the Purchase Option Closing Date, shall convey good and marketable title to
such Company Common Stock, free from any Encumbrances and any and all other restrictions requiring
that any issuance, sale, assignment or other transfer of such Company Common Stock be consented to
or approved by any Person.

11

 

                    (iii) If the share certificates representing such Company Common Stock include the 33 Act
Legend (as set forth in Section 2(f) hereof), Company shall, within two (2) Business Days
of receiving a request from Holdings or any Investor (as defined in the Registration Rights
Agreement), remove or cause to be removed the 33 Act Legend from such share certificates as
Holdings or such Investor shall designate, so long as (x) the Company Common Stock represented by
such share certificates has been transferred to a third party in compliance with (A) the
registration requirements of the Securities Act or (B) Rule 144 under the Securities Act, and the
Company receives a certification from Holdings, such Investor or a securities broker designated by
Holdings or such Investor to the effect that the sale of such Company Common Stock was made under a
Registration Statement and accompanied by the delivery of a current prospectus or pursuant to Rule
144.

                    (iv) Upon the expiration of the Purchase Option or the termination of this Agreement pursuant
to Section 9 hereof, or as soon thereafter as is practical, the Company shall (A) in
accordance with and pursuant to Sections 2.7 and 2.8 of the Novated and Restated
Technology License Agreement, deliver to the Symphony Collaboration all Regulatory Files and
Tangible Materials, and (B) in accordance with and pursuant to Section 2.11 of the Novated
and Restated Technology License Agreement, provide and supply, or cause to be provided and
supplied, finished dosage form of Products.

                    (v) In the event that the Company exercises the Purchase Option, then the Company shall
maintain the separate corporate existence of the Symphony Collaboration for a minimum of one
(1) year following such exercise, unless such maintenance would have a Material Adverse Effect on
the Company or any of its Affiliates.

          Section 4. Holdings Representations, Warranties and Covenants.

               (a) As of the date hereof, Holdings hereby represents and warrants, and, except to the extent
that any of the following representations and warranties are limited to the date of this Agreement
or otherwise limited, on the Purchase Option Closing Date, shall be deemed to have represented and
warranted, to the Company and the Symphony Collaboration that:

                    (i) Organization. Holdings is a limited liability company, duly formed, validly
existing and in good standing under the laws of the State of Delaware.

                    (ii) Authority and Validity. Holdings has all requisite limited liability company
power and authority to execute, deliver and perform its obligations under this Agreement and to
consummate the transactions contemplated hereby. The execution, delivery and performance by
Holdings of this Agreement and the consummation of the transactions contemplated hereby have been
duly and validly authorized by all necessary action required on the part of Holdings, and no other
proceedings on the part of Holdings are necessary to authorize this Agreement or for

12

 

Holdings to
perform its obligations under this Agreement. This Agreement constitutes the lawful, valid and
legally binding obligation of Holdings, enforceable in accordance with its terms, except as the
same may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar
laws affecting the enforcement of creditors’ rights generally and general equitable principles
regardless of whether such enforceability is considered in a proceeding at law or in equity.

                    (iii) No Violation or Conflict. The execution, delivery and performance of this
Agreement and the transactions contemplated hereby do not (A) violate, conflict with or result in
the breach of any provision of the Organizational Documents of Holdings, (B) as of the date of this
Agreement, and as of the Purchase Option Closing Date if the Company elects to make a Partial Stock
Payment, conflict with or violate any law or Governmental Order applicable to Holdings or any of
its assets, properties or businesses, or (C) as of the date of this Agreement, and as of the
Purchase Option Closing Date if Company elects to make a Partial Stock Payment, conflict with,
result in any breach of, constitute a default (or event that with the giving of notice or lapse of
time, or both, would become a default) under, require any consent under, or give to others any
rights of termination, amendment, acceleration, suspension, revocation or cancellation of, or
result in the creation of any Encumbrance on any of the assets or properties of Holdings, pursuant
to, any note, bond, mortgage or indenture, contract, agreement, lease, sublease, license, permit,
franchise or other instrument or arrangement to which Holdings is a party except, in the case of
clauses (B) and (C), to the extent that such conflicts, breaches, defaults or other
matters would not, individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect on Holdings.

                    (iv) Governmental Consents and Approvals. The execution, delivery and performance of
this Agreement by Holdings do not, and the consummation of the transactions contemplated hereby do
not and will not, require any Governmental Approval which has not already been obtained, effected
or provided, except with respect to which the failure to so obtain, effect or provide would not,
individually or in the aggregate, reasonably be expected to have a Material Adverse Effect on
Holdings.

                    (v) Litigation. As of the date of this Agreement, there are no actions by or against
Holdings pending before any Governmental Authority or, to the knowledge of Holdings, threatened to
be brought by or before any Governmental
Authority, that would, individually or in the aggregate, reasonably be expected to have a
Material Adverse Effect on Holdings. There are no pending or, to the knowledge of Holdings,
threatened actions to which Holdings is a party (or is threatened to be named as a party) to set
aside, restrain, enjoin or prevent the execution, delivery or performance of this Agreement or the
Operative Documents or the consummation of the transactions contemplated hereby or thereby by any
party hereto or thereto. As of the date of this Agreement, Holdings is not subject to any
Governmental Order (nor, to the knowledge of Holdings, is there any such Governmental Order
threatened to be imposed by any Governmental Authority) that would, individually or in the
aggregate, reasonably be expected to have a Material Adverse Effect on Holdings.

13

 

                    (vi) Stock Ownership. All of the Symphony Collaboration’s issued and outstanding
Symphony Collaboration Equity Securities are owned beneficially and of record by Holdings, free and
clear of any and all encumbrances.

                    (vii) Interim Operations. Holdings was formed solely for the purpose of engaging in
the transactions contemplated by the Operative Documents, has engaged in no other business
activities and has conducted its operations only as contemplated by the Operative Documents.

                    (viii) Accredited Investor.

                    (A) Holdings is and will remain at all relevant times an Accredited Investor.

                    (B) Holdings has relied completely on the advice of, or has consulted with or has had the
opportunity to consult with, its own personal tax, investment, legal or other advisors and has not
relied on the Company or any of its Affiliates, representatives or advisors for advice. Holdings
acknowledges that investing in the Company Securities involves certain risks. Holdings
acknowledges that it has had a reasonable opportunity to conduct its own due diligence with respect
to the Products, the Programs, the Symphony Collaboration, the Company and the transactions
contemplated by the Operative Documents.

                    (C) Holdings has been advised and understands that the offer and sale of the Company
Securities have not been registered under the Securities Act. Holdings is able to bear the
economic risk of such investment for an indefinite period and to afford a complete loss thereof.

                    (D) Holdings is and will be, as applicable, acquiring the Company Securities solely for
Holdings’ own account for investment purposes as a principal and not with a view to the resale of
all or any part thereof; provided, that Holdings may transfer the Company Securities as set forth
in Section 6.01 of the Stock and Warrant Purchase Agreement. Holdings agrees that the
Company Securities may not be resold (1) without registration thereof under the Securities Act
(unless an exemption from such registration is available), or (2) in violation of any Law.
Holdings is not and
will not be an underwriter within the meaning of Section 2(11) of the Securities Act with
respect to the Company Securities.

                    (E) No person or entity acting on behalf of, or under the authority of, Holdings is or will be
entitled to any broker’s, finder’s, or similar fees or commission payable by the Company or any of
its Affiliates.

                    (F) Holdings acknowledges and agrees to treat the Option Premium Shares, with a value of
$4,000,000, and the Additional Investment Shares, with a value of up to $1,000,000, for federal,
state and local income tax purposes as an option premium paid in return for the grant and
maintenance of the Purchase Option and the Additional Holdings Funding, as applicable.

14

 

               (b) Holdings hereby covenants and agrees with the Company as follows:

                    (i) Contribution to Symphony Collaboration. On or prior to the Stock Payment Date,
Holdings shall, pursuant to the Subscription Agreement, contribute proceeds from the Financing of
$15,000,000 to the Symphony Collaboration.

                    (ii) Payment to the Company. On the Share Date, Holdings shall, pursuant to the Stock
and Warrant Purchase Agreement, pay proceeds from the Financing of $2,477,117.07 to the Company.

                    (iii) Encumbrance. Holdings will not, and will not permit any of its Subsidiaries to,
create, assume or suffer to exist any Encumbrance on any of its Symphony Collaboration Equity
Securities except with the prior written consent of the Company.

                    (iv) Transfer and Amendment. Commencing upon the date hereof and ending upon the
earlier to occur of (x) the Purchase Option Closing Date, (y) the unexercised expiration of the
Purchase Option Period, and (z) the termination of this Agreement pursuant to Section 9
(such period, the “Term”), the manager of Holdings shall not (A) transfer, or permit the
transfer of, any Membership Interest without the prior written consent of the Company or (B) amend,
or permit the amendment of, any provisions relating to the transfer of Membership Interests, as set
forth in Section 7.02 of the Holdings LLC Agreement, to the extent such amendment would
adversely affect the Company’s right of consent set forth in Sections 7.02(b)(i) and
7.02(c) of the Holdings LLC Agreement.

                    (v) Symphony Collaboration Directors. During the Term, Holdings agrees to vote all of
its Symphony Collaboration Equity Securities (or to exercise its right with respect to such
Symphony Collaboration Equity Securities to consent to action in writing without a meeting) in
favor of, as applicable, the election, removal and replacement of one director of the Symphony
Collaboration Board, and any successor thereto, designated by the Company (the “Company
Director”) as directed by the Company. In furtherance and not in limitation of the foregoing,
Holdings hereby grants to the Company an irrevocable proxy, with respect to all Symphony
Collaboration
Equity Securities now owned or hereafter acquired by Holdings, to vote such Symphony
Collaboration Equity Securities or to exercise the right to consent to action in writing without a
meeting with respect to such Symphony Collaboration Equity Securities, such irrevocable proxy to be
exercised solely for the limited purpose of electing, removing and replacing the Company Director
in the event of the failure or refusal of Holdings to elect, remove or replace such Company
Director, as directed by the Company. Additionally, Holdings agrees, during the Term, to elect two
(2) independent directors to the Symphony Collaboration Board, and any successors thereto, as shall
be selected by mutual agreement of the Company and Holdings.

                    (vi) Symphony Collaboration Board. During the Term, Holdings shall not vote any of
its Symphony Collaboration Equity Securities (or exercise

15

 

its rights with respect to such Symphony
Collaboration Equity Securities by written consent without a meeting) to increase the size of the
Symphony Collaboration Board to more than five (5) members without the prior written consent of the
Company.

                    (vii) Symphony Collaboration Charter. During the Term, Holdings shall not approve or
permit any amendment to Article IV, Paragraphs (1) and (3); Article VI;
Article VII; Article VIII; Article X; Article XI or
Article XIII of the Symphony Collaboration Charter without the prior written consent of the
Company.

          Section 5. Symphony Collaboration Representations, Warranties and Covenants.

               (a) As of the date hereof, the Symphony Collaboration hereby represents and warrants, and,
except to the extent that any of the following representations and warranties are limited to the
date of this Agreement or otherwise limited, on the Purchase Option Closing Date, shall be deemed
to have represented and warranted, to the Company and Holdings that:

                    (i) Organization. The Symphony Collaboration is a corporation, duly organized,
validly existing and in good standing under the laws of the State of Delaware.

                    (ii) Authority and Validity. The Symphony Collaboration has all requisite corporate
power and authority to execute, deliver and perform its obligations under this Agreement and to
consummate the transactions contemplated hereby. The execution, delivery and performance by the
Symphony Collaboration of this Agreement and the consummation of the transactions contemplated
hereby have been duly and validly authorized by all necessary action required on the part of the
Symphony Collaboration, and no other proceedings on the part of the Symphony Collaboration are
necessary to authorize this Agreement or for the Symphony Collaboration to perform its obligations
under this Agreement. This Agreement constitutes the lawful, valid and legally binding obligation
of the Symphony Collaboration, enforceable in accordance with its terms, except as the same may be
limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws
affecting the enforcement of creditors’ rights generally and general equitable principles
regardless of whether such enforceability is considered in a proceeding at law or in equity.

                    (iii) No Violation or Conflict. The execution, delivery and performance of this
Agreement and the transactions contemplated hereby do not (A) violate, conflict with or result in
the breach of any provision of the Organizational Documents of the Symphony Collaboration,
(B) conflict with or violate any law or Governmental Order applicable to the Symphony Collaboration
or any of its assets, properties or businesses, or (C) conflict with, result in any breach of,
constitute a default (or event that with the giving of notice or lapse of time, or both, would
become a default) under, require any consent under, or give to others any rights of termination,
amendment, acceleration, suspension, revocation or cancellation of, or result in the creation of
any

16

 

Encumbrance on any of the assets or properties of the Symphony Collaboration, pursuant to, any
note, bond, mortgage or indenture, contract, agreement, lease, sublease, license, permit, franchise
or other instrument or arrangement to which the Symphony Collaboration is a party except, in the
case of clauses (B) and (C), to the extent that such conflicts, breaches, defaults
or other matters would not, individually or in the aggregate, reasonably be expected to have a
Material Adverse Effect on the Symphony Collaboration.

                    (iv) Governmental Consents and Approvals. The execution, delivery and performance of
this Agreement by the Symphony Collaboration do not, and the consummation of the transactions
contemplated hereby do not and will not, require any Governmental Approval which has not already
been obtained, effected or provided, except with respect to which the failure to so obtain, effect
or provide would not, individually or in the aggregate, reasonably be expected to have a Material
Adverse Effect on the Symphony Collaboration.

                    (v) Litigation. There are no actions by or against the Symphony Collaboration pending
before any Governmental Authority or, to the knowledge of the Symphony Collaboration, threatened to
be brought by or before any Governmental Authority that would, individually or in the aggregate,
reasonably be expected to have a Material Adverse Effect on the Symphony Collaboration. There are
no pending or, to the knowledge of the Symphony Collaboration, threatened actions to which the
Symphony Collaboration is a party (or is threatened to be named as a party) to set aside, restrain,
enjoin or prevent the execution, delivery or performance of this Agreement or the Operative
Documents or the consummation of the transactions contemplated hereby or thereby by any party
hereto or thereto. The Symphony Collaboration is not subject to any Governmental Order (nor, to
the knowledge of the Symphony Collaboration, is there any such Governmental Order threatened to be
imposed by any Governmental Authority) that would, individually or in the aggregate, reasonably be
expected to have a Material Adverse Effect on the Symphony Collaboration.

                    (vi) Capitalization. Holdings is the beneficial and record owner of all issued and
outstanding Symphony Collaboration Equity Securities. No shares of the Symphony Collaboration
capital stock are held in treasury by the Symphony Collaboration or any Symphony Collaboration
Subsidiary. All of the issued and outstanding Symphony Collaboration Equity Securities (A) have
been duly authorized and validly issued and are fully paid and nonassessable, (B) were issued in
compliance with all applicable state and federal securities laws, and (C) were not issued in
violation of any preemptive rights or rights of first refusal. No preemptive rights or rights of
first refusal exist with respect to any Symphony Collaboration Equity Securities and no such rights
will arise by virtue of or in connection with the transactions contemplated hereby (other than for
the Purchase Option). Other than the Purchase Option, there are no outstanding options, warrants,
call rights, commitments or agreements of any character to acquire any Symphony Collaboration
Equity Securities. There are no outstanding stock appreciation, phantom stock, profit
participation or other similar rights with respect to the Symphony Collaboration. The Symphony
Collaboration

17

 

is not obligated to redeem or otherwise acquire any of its outstanding Symphony
Collaboration Equity Securities.

                    (vii) Interim Operations. The Symphony Collaboration was formed solely for the
purpose of engaging in the transactions contemplated by the Operative Documents, has engaged in no
other business activities and has conducted its operations only as contemplated by the Operative
Documents.

                    (viii) Investment Company. The Symphony Collaboration is not, and after giving effect
to the transactions contemplated by the Operative Documents will not be, required to register as an
“investment company” as such term is defined in the Investment Company Act of 1940, as
amended.

               (b) The Symphony Collaboration covenants and agrees that:

                    (i) The Symphony Collaboration will comply with all laws, ordinances or governmental rules or
regulations to which it is subject and will obtain and maintain in effect all licenses,
certificates, permits, franchises and other Governmental Approvals necessary to the ownership of
its properties or to the conduct of its business, in each case to the extent necessary to ensure
that non-compliance with such laws, ordinances or governmental rules or regulations or failures to
obtain or maintain in effect such licenses, certificates, permits, franchises and other
Governmental Approvals would not, individually or in the aggregate, reasonably be expected to have
a Material Adverse Effect on the Symphony Collaboration.

                    (ii) The Symphony Collaboration will file (or cause to be filed) all material tax returns
required to be filed by it and pay all taxes shown to be due and payable on such returns and all
other taxes imposed on it or its assets to the extent such taxes have become due and payable and
before they have become delinquent and shall pay all claims for which sums have become due and
payable that have or might become attached to the assets of the Symphony Collaboration;
provided, that the Symphony Collaboration need not file any such tax returns or pay any
such tax or claims
if (A) the amount, applicability or validity thereof is contested by the Symphony
Collaboration on a timely basis in good faith and in appropriate proceedings, and the Symphony
Collaboration has established adequate reserves therefor in accordance with GAAP on the books of
the Symphony Collaboration or (B) the failure to file such tax returns or the nonpayment of such
taxes and assessments, individually or in the aggregate, could not reasonably be expected to have a
Material Adverse Effect on the Symphony Collaboration.

                    (iii) The Symphony Collaboration will at all times preserve and keep in full force and effect
its corporate existence.

                    (iv) The Symphony Collaboration will keep complete, proper and separate books of record and
account, including a record of all costs and expenses incurred, all charges made, all credits made
and received, and all income derived in connection with the operation of the business of the
Symphony Collaboration,

18

 

all in accordance with GAAP (which GAAP shall be conformed to those used by
the Company to the extent practicable), in each case to the extent necessary to enable the Symphony
Collaboration to comply with the periodic reporting requirements of this Agreement, and will
promptly notify the Company if it adopts or changes any accounting principle pursuant to a change
in GAAP or applicable Law.

                    (v) The Symphony Collaboration will perform and observe in all material respects all of the
terms and provisions of each Operative Document to be performed or observed by it, maintain each
such Operative Document to which it is a party, promptly enforce in all material respects each such
Operative Document in accordance with its terms, take all such action to such end as may be from
time to time reasonably requested by Holdings or the Company and make to each other party to each
such Operative Document such demands and requests for information and reports or for action as the
Symphony Collaboration is entitled to make under such Operative Document.

                    (vi) The Symphony Collaboration shall permit the representatives of Holdings (including
Holdings’ members and their respective representatives), each Symphony Fund and the Company, at
each of their own expense and upon reasonable prior notice to the Symphony Collaboration, to visit
the principal executive office of the Symphony Collaboration, to discuss the affairs, finances and
accounts of the Symphony Collaboration with the Symphony Collaboration’s officers and (with the
consent of the Symphony Collaboration, which consent will not be unreasonably withheld) its
Auditors, all at such reasonable times and as often as may be reasonably requested in writing.

                    (vii) The Symphony Collaboration shall permit each Symphony Fund, at its own expense and upon
reasonable prior notice to the Symphony Collaboration, to inspect and copy the Symphony
Collaboration’s books and records and inspect the Symphony Collaboration’s properties at reasonable
times.

                    (viii) The Symphony Collaboration shall allow the Company or its designated representatives to
have reasonable visitation and inspection rights with regard to the Programs and materials,
documents and other information relating thereto.

                    (ix) The Symphony Collaboration shall permit each Symphony Fund to consult with and advise the
management of the Symphony Collaboration on matters relating to the research and development of the
Programs in order to develop the Product in accordance with the terms or provisions of the Amended
and Restated Research and Development Agreement.

                    (x) On the Purchase Option Closing Date, or as soon thereafter as is practical, the Symphony
Collaboration shall deliver to the Company all materials, documents, files and other information
relating to the Programs (or, where necessary, copies thereof).

19

 

                    (xi) During the Term, the Company shall have the right to consent to any increase in the size
of the Symphony Collaboration Board to more than five (5) directors.

                    (xii) During the Term, the Company shall have the right to designate, remove and replace one
(1) director of the Symphony Collaboration Board, including any successor thereto, as contemplated
by Section 4(b)(v).

                    (xiii) The Symphony Collaboration shall indemnify the directors and officers of the Symphony
Collaboration against liability incurred by reason of the fact that such Person is or was a
director or officer of the Symphony Collaboration, as permitted by Article VIII of the
Symphony Collaboration Charter and Section 9.01 of the Symphony Collaboration By-laws, as
set forth in, and on the terms of, the Indemnification Agreement and the RRD Services Agreement,
respectively.

                    (xiv) During the Term, the Symphony Collaboration shall comply with, and cause any Persons
acting for it to comply with, the terms of the Investment Policy with respect to the investment of
any funds held by it.

                    (xv) On or prior to the Purchase Option Closing Date, the Symphony Collaboration shall pay for
non-cancelable run-off insurance policies covering claims made or reported for a period of six (6)
years after the Purchase Option Closing Date to provide insurance coverage for events, acts or
omissions occurring on or prior to the Purchase Option Closing Date for all persons or business
entities who were covered as insured parties by the applicable insurance policies on or prior to
the Purchase Option Closing Date.

               (c) The Symphony Collaboration covenants and agrees that, until the expiration of the Term, it
shall not, and shall cause its Subsidiaries (if any) not to, without the Company’s prior written
consent:

                    (i) issue any Symphony Collaboration Equity Securities or any Equity Securities of any
Subsidiary thereof (other than any issuances of Equity Securities by the Symphony Collaboration
made in accordance with Section 1(b) hereof to Holdings so long as the Symphony
Collaboration is a wholly owned subsidiary of Holdings, or by a Subsidiary of the Symphony
Collaboration to the Symphony Collaboration or to another wholly owned Subsidiary of the Symphony
Collaboration); provided, however, that in any event any such Symphony
Collaboration Equity Securities shall be issued subject to the Purchase Option;

                    (ii) redeem, repurchase or otherwise acquire, directly or indirectly, any Symphony
Collaboration Equity Securities or the Equity Securities of any Subsidiary of the Symphony
Collaboration;

                    (iii) create, incur, assume or permit to exist Debt other than any Debt owing to parties not
affiliated with the Symphony Collaboration incurred pursuant to the Operative Documents and the
Development Budget (including payables incurred in the ordinary course of business) (“Excepted
Debt”); provided, however, that

20

 

the aggregate outstanding principal amount of
all Excepted Debt for borrowed money shall not exceed $1,000,000 at any time;

                    (iv) declare or pay dividends or other distributions on any Symphony Collaboration Equity
Securities other than any dividend declared out of funds released by the Development Committee
pursuant to Section 8.1(b) of the Amended and Restated Research and Development Agreement
in respect of Discontinued Funds or from the proceeds of (x) the exercise of a Discontinuation
Option, or (y) a sale or license of a discontinued Program to a third party, in each case in
respect of which the Symphony Collaboration shall be entitled to pay (subject to the existence of
lawfully available funds) a dividend equal to the net amount (such net amount calculated as the
gross proceeds received less amounts required to be paid in respect of any and all corporate taxes
owed by the Symphony Collaboration as a result of the receipt of such gross amounts) of such
Discontinuation Price or the amounts received from such third party, as the case may be;

                    (v) enter into any transaction of merger or consolidation, or liquidate, wind up or dissolve
itself, or convey, transfer, license, lease or otherwise dispose of all, or a material portion of,
its properties, assets or business;

                    (vi) other than in respect of the Programs, engage in the development of products for any
other company or engage or participate in the development of products or engage in any other
material line of business;

                    (vii) other than entering into, and performing its obligations under, the Operative Documents
and participating in the Programs, engage in any action that negates or is inconsistent with any
rights of the Company set forth herein;

                    (viii) (A) other than as contemplated by the RRD Services Agreement and Section 6.2 of
the Amended and Restated Research and
Development Agreement, hire, retain or contract for the services of, any employees until the
termination of such agreements, or (B) appoint, dismiss or change any RRD Investment Personnel;

                    (ix) incur any financial commitments in respect of the development of the Programs other than
those set forth in the Development Plan and the Development Budget, or those approved by the
Development Committee and, if so required by the terms of Paragraph 11 of the Development Committee
Charter, the Symphony Collaboration Board in accordance with the Operative Documents;

                    (x) other than any transaction contemplated by the Operative Documents, enter into or engage
in any Conflict Transactions without the prior approval of a majority of the Disinterested
Directors of the Symphony Collaboration Board;

                    (xi) waive, alter, modify, amend or supplement in any manner whatsoever any material terms and
conditions of the RRD Services Agreement, the Subscription Agreement, the Additional Funding
Agreement, or Articles 4 and 6 of

21

 

the Amended and Restated Research and Development
Agreement, except in compliance with the terms of the Operative Documents; or

                    (xii) enter into any alliance or partnership arrangement for the commercialization or
marketing of any Products under the Programs.

               (d) The Symphony Collaboration covenants and agrees to deliver, cause to be delivered, and
provide access thereto, to each other Party, each Symphony Fund, and such Auditors as the Company
may designate, so long as such Auditors shall (x) be subject to confidentiality requirements at
least as stringent as the Confidentiality Agreement or (y) be the Company Accounting Advisor
retained pursuant to an agreement which incorporates confidentiality provisions substantially the
same as the ones incorporated in the agreements in effect between the Company and such Company
Accounting Advisor as of the Closing Date:

                    (i) upon request, copies of the then current Development Plan for each quarter, on or before
March 31, June 30, September 30, and December 31 of each year;

                    (ii) upon request, copies of the then current Development Budget for each quarter, including a
report setting forth in reasonable detail the projected expenditures by the Symphony Collaboration
pursuant to the Development Budget, on or before March 31, June 30, September 30, and December 31
of each year;

                    (iii) prior to the close of each fiscal year, the Symphony Collaboration shall cause the
Manager to seek to obtain from the Symphony Collaboration Auditors schedules of certain financial
information to be provided to the Company’s Auditors in connection with the Symphony Collaboration
Auditors’ audit of the Symphony Collaboration. Within fifteen (15) Business Days after the close
of each fiscal year, the Symphony Collaboration (or the Manager acting on its behalf) will
provide the Company’s Auditors with the Client Schedules. If the Symphony Collaboration
Auditors deliver the notice or listing of required Client Schedules after the end of the fiscal
year, the Symphony Collaboration (or the Manager acting on its behalf) will provide the completed
Client Schedules to the Company’s Auditors within fifteen (15) Business Days of such receipt.
Following the Company’s Auditors’ review of the Client Schedules, the Symphony Collaboration (or
the Manager acting on its behalf) will promptly provide the Company’s Auditors with any reasonably
requested back-up information related to the Client Schedules;

                    (iv) upon the Company’s Auditors’ request, the Company’s Chief Financial Officer, the Symphony
Collaboration Auditors, the Company’s Auditors and the Symphony Collaboration (or the Manager
acting on its behalf) shall agree to a completion schedule that will include (A) the provision by
the Symphony Collaboration to the Company of the financial information reasonably necessary for the
Company to consolidate the financial results of the Symphony Collaboration and (B) the following
financial statements, including the related notes thereto, audited and certified by the Symphony
Collaboration Auditors: (1) a balance

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sheet of the Symphony Collaboration as of the close of such
fiscal year, (2) a statement of operations for such fiscal year, and (3) a statement of cash flows
for such fiscal year. Such audited annual financial statements shall set forth in comparative form
the figures for the previous fiscal year, all in reasonable detail, prepared in accordance with
GAAP, and the Symphony Collaboration (or the Manager acting on its behalf) shall, to the extent
that the Symphony Collaboration (or the Manager acting on its behalf) can procure such an opinion
using commercially reasonable means, be accompanied by an opinion thereon of the Symphony
Collaboration Auditors to the effect that such financial statements present fairly, in all material
respects, the financial position of the Symphony Collaboration and its results of operations and
cash flows and have been prepared in conformity with GAAP, and that the examination of such
accountants in connection with such financial statements has been made in accordance with generally
accepted auditing standards, and that such audit provides a reasonable basis for such opinion in
the circumstances;

                    (v) within seven (7) Business Days following each calendar month and receipt from the Company
of its monthly invoice to the Symphony Collaboration, current accrued monthly vendor expenses and
prepaid expenses, the Symphony Collaboration (or the Manager acting on its behalf) will provide to
the Company: (A) the unaudited balance sheet of the Symphony Collaboration for the previous
calendar month; (B) the unaudited statement of operations for such previous calendar month; (C) 
the trial balance schedule for such previous calendar month; and (D) related account
reconciliations for such previous calendar month (collectively, “Unaudited Financial
Information”);

                    (vi) within five (5) Business Days following its filing, a copy of each income tax return so
filed by the Symphony Collaboration with any foreign, federal, state or local taxing authority
(including all supporting schedules thereto);

                    (vii) any other documents, materials or other information pertaining to the Programs or the
Symphony Collaboration as the Company may reasonably request, including preliminary financial
information and information and documentation of internal controls and reporting;

                    (viii) promptly, and in any event within five (5) Business Days of receipt thereof, copies of
any notice to the Symphony Collaboration from any federal or state Governmental Authority relating
to any order, ruling, statute or other law or regulation that would reasonably be expected to have
a Material Adverse Effect on the Symphony Collaboration;

                    (ix) promptly upon receipt thereof, notice of all actions, suits, investigations, litigation
and proceedings before any court or governmental department, commission, board, bureau, agency or
instrumentality, domestic or foreign, affecting the Symphony Collaboration;

                    (x) promptly upon receipt thereof, copies of any other notices, requests, reports, financial
statements and other information and documents

23

 

received by the Symphony Collaboration under or
pursuant to any other Operative Document, including, without limitation, any notices of breach or
termination of any subcontracts or licenses entered into or permitted pursuant to the Operative
Documents; and

                    (xi) with reasonable promptness, such other data and information relating to the business,
operations, affairs, financial condition, assets or properties of the Symphony Collaboration or
relating to the ability of the Symphony Collaboration to perform its obligations hereunder and
under the Operative Documents as from time to time may be reasonably requested by the Company
and/or Holdings;

provided, that neither the Symphony Collaboration, nor the Manager acting on behalf of the
Symphony Collaboration, shall have any liability to the Company for the failure to deliver
financial documents or other materials hereunder, if such failure was caused by a failure of the
Company to provide, in a timely manner, data required to prepare such financial documents or other
materials to the Symphony Collaboration in a timely manner.

               (e) The Symphony Collaboration will use commercially reasonable efforts, at its own expense
(as set forth in the Development Budget), to cooperate with the Company in meeting the Company’s
government compliance, disclosure, and financial reporting obligations, including without
limitation under the Sarbanes-Oxley Act of 2002, as amended, and any rules and regulations
promulgated thereunder, under FASB Interpretation No. 46 (Revised) and under the Exchange Act.
Without limiting the foregoing, the Symphony Collaboration further covenants, until the completion
of all the reporting, accounting and other obligations set forth therein with respect to the fiscal
year in which this Agreement shall terminate, expire and end, that (w) if requested by the Symphony
Collaboration Auditors, the principal executive officer and the principal financial officer of the
Symphony Collaboration, or persons performing
similar functions, shall provide certifications to the Company corresponding to those required
with respect to public companies for which a class of securities is registered under the Exchange
Act (“Public Companies”) under Sections 302 and 906 of the Sarbanes-Oxley Act of 2002, as
amended; (x) the Symphony Collaboration shall maintain a system of disclosure controls and internal
controls (as defined under the Exchange Act) as required under the Exchange Act for Public
Companies, if required by the Company’s Auditors in connection with their audit of the Company;
(y) the Symphony Collaboration shall provide to the Company an attestation report of the Symphony
Collaboration Auditors with respect to the Symphony Collaboration management’s assessment of the
Symphony Collaboration’s internal controls as required under the Exchange Act for Public Companies,
if required by the Company’s Auditors in connection with their audit of the Company; and (z) the
Symphony Collaboration will maintain, or cause to have maintained, such sufficient evidentiary
support for management’s assessment of the effectiveness of the Symphony Collaboration’s internal
controls as required under the Exchange Act for Public Companies.

          Section 6. Notice of Material Event. Each Party covenants and agrees that, upon its acquiring
Knowledge of (a) any breach by it of any representation,

24

 

warranty, covenant or any other term or
condition of this Agreement or (b) any other event or development, in each case that is, or is
reasonably expected to be, materially adverse to the other Party with respect to any Program or the
transactions contemplated hereby, such Party shall promptly notify the other Party in writing
within three (3) Business Days of acquiring such Knowledge; provided, that neither the
provision of nor the failure to provide such notice shall impair or otherwise be deemed a waiver of
any rights any Party may have arising from such breach, event or development and that notice under
this Section 6 shall not be deemed an admission by the Party providing such notice of any
breach of any of the Operative Documents.

          Section 7. Assignment; Transfers; Legend.

               (a) Assignment by Company and Symphony Collaboration. Neither the Company nor the
Symphony Collaboration may assign, delegate, transfer, sell or otherwise dispose of (collectively,
“Transfer”), in whole or in part, any or all of their rights or obligations hereunder to
any Person (a “Transferee”) without the prior written approval of each of the other
Parties; provided, however, that the Company, without the prior approval of each of
the other Parties, subject to Section 2A of this Agreement, may make such Transfer to any
Person which acquires all or substantially all of the Company’s assets or business (or assets or
business related to the Programs) or which is the surviving or resulting Person in a merger,
consolidation or other reorganization with the Company.

               (b) Assignment and Transfers by Holdings. Prior to the expiration of the Term,
Holdings may not Transfer, in whole or in part, any or all of its
Symphony Collaboration Equity Securities or any or all of its rights or obligations hereunder
to any Person (other than the Company) without the prior written consent of the Company. In
addition, any Transfer of Symphony Collaboration Equity Securities by Holdings or any other Person
to any Person other than the Company shall be conditioned upon, and no effect shall be given to any
such Transfer unless such transferee shall agree in writing in form and substance satisfactory to
the Company to be bound by, all of the terms and conditions hereunder, including the Purchase
Option, as if such transferee were originally designated as “Holdings” hereunder.

               (c) Legend. Any certificates evidencing Symphony Collaboration Equity Securities
shall bear a legend in substantially the following form:

THE SECURITIES OF SYMPHONY ViDA, INC., EVIDENCED HEREBY ARE
SUBJECT TO AN OPTION, HELD BY OXiGENE, INC., AS DESCRIBED IN A
PURCHASE OPTION AGREEMENT (THE “PURCHASE OPTION
AGREEMENT”) DATED AS OF OCTOBER 1, 2008, BY AND AMONG OXiGENE,
INC. AND THE OTHER PARTIES THERETO, TO PURCHASE SUCH SECURITIES AT
A PURCHASE PRICE DETERMINED PURSUANT TO SECTION 2 OF THE
PURCHASE OPTION AGREEMENT,

25

 

EXERCISABLE BY WRITTEN NOTICE AT ANY
TIME DURING THE PERIOD SET FORTH THEREIN. COPIES OF THE PURCHASE
OPTION AGREEMENT ARE AVAILABLE AT THE PRINCIPAL PLACE OF BUSINESS
OF SYMPHONY ViDA, INC. AT 7361 CALHOUN PLACE, SUITE 325,
ROCKVILLE, MARYLAND 20855, AND WILL BE FURNISHED TO THE HOLDER
HEREOF UPON WRITTEN REQUEST WITHOUT COST.

          Section 8. Costs and Expenses; Payments.

               (a) The Symphony Collaboration Costs and Expenses. The Symphony Collaboration shall
pay any of its ongoing legal expenses with respect to the transactions described in the Operative
Documents from the funds allocated for such purpose in the Development Budget.

               (b) Costs and Expenses of the Purchase Option. Except as otherwise specified in
Section 2(g) hereof, each Party shall pay its own costs and expenses incurred in connection
with the exercise of the Purchase Option.

               (c) Payments to Holdings. Subject to Section 2(c), payment of the Purchase
Price, plus any costs and expenses payable by the Symphony Collaboration
under Section 2(g) hereof, shall be made to the account of Holdings on the Purchase
Option Closing Date no later than 1:00 pm (New York time).

          Section 9. Expiration; Termination of Agreement.

               (a) Termination.

                    (i) This Agreement shall terminate upon the mutual written consent of all of the Parties.

                    (ii) Subject to Sections 1(c)(iv) and 2A hereof, which shall survive
termination of this Agreement under this Section 9(a)(ii), each of Holdings and the
Symphony Collaboration may terminate this Agreement in the event that the Symphony Collaboration
terminates the Amended and Restated Research and Development Agreement in accordance with its
terms.

          Section 10. Survival; Indemnification.

               (a) Survival of Representations and Warranties; Expiration of Certain Covenants.

                    (i) The representations and warranties of the Parties contained in this Agreement shall
survive for a period of one year from the making of such representations, except for
representations and warranties contained in Sections 3(a)(i) and (ii), 4(a)(i) and
(ii) and 5(a)(i) and (ii) hereof which shall survive

26

 

indefinitely. The liability of
the Parties related to their respective representations and warranties hereunder shall not be
reduced by any investigation made at any time by or on behalf of Holdings, the Symphony
Collaboration or the Company, as applicable.

                    (ii) For the avoidance of doubt, the covenants and agreements set forth in
Sections 4(b), 5(b)(i), 5(b)(v), 5(b)(vii)-(ix),

5(b)(xi)-(xiv), 5(c), 5(d)(i), 5(d)(ii) and
5(d)(viii)-(xi) shall, upon the expiration of the Term, expire and end without any further
obligation by the Symphony Collaboration or Holdings thereunder.

                    (iii) For the avoidance of doubt, the covenants and agreements set forth in
Sections 5(b)(ii)-(iv), 5(b)(vi), 5(b)(x), 5(d)(iii)-(vii) and
5(e) shall, upon the completion of all the reporting, accounting and other obligations set
forth therein with respect to the fiscal year in which this Agreement shall terminate, expire and
end without any further obligation by the Symphony Collaboration or Holdings thereunder.

               (b) Indemnification. To the greatest extent permitted by applicable law, the Company
shall indemnify and hold harmless the Symphony Collaboration and Holdings, and the Symphony
Collaboration and Holdings shall
indemnify and hold harmless the Company, and each of their respective Affiliates, officers,
directors, employees, agents, partners, members, successors, assigns, representatives of, and each
Person, if any (including any officers, directors, employees, agents, partners, members of such
Person) who controls Holdings, the Symphony Collaboration and the Company, as applicable, within
the meaning of the Securities Act or the Exchange Act (each, an “Indemnified Party”), from
and against any and all actions, causes of action, suits, claims, losses, costs, interest, fees,
liabilities and damages, and expenses in connection therewith (irrespective of whether any such
Indemnified Party is a party to the action for which indemnification hereunder is sought), and
including reasonable attorneys’ fees and disbursements (hereinafter, a “Loss”), incurred by
any Indemnified Party to the extent resulting from, arising out of, or relating to: (i) in the
case of the Company being the Indemnifying Party, (A) any breach of any representation or warranty
made by the Company herein or in Section 5.1 of the Novated and Restated Technology License
Agreement, or (B) any breach of any covenant, agreement or obligation of the Company contained
herein, and (ii) in the case of Holdings being the Indemnifying Party, (A) any breach of any
representation or warranty made by Holdings or the Symphony Collaboration herein, or (B) any breach
of any covenant, agreement or obligation of Holdings or the Symphony Collaboration contained
herein. To the extent that the foregoing undertaking by the Company or Holdings may be
unenforceable for any reason, such Party shall make the maximum contribution to the payment and
satisfaction of any Loss that is permissible under applicable law.

               (c) Notice of Claims. Any Indemnified Party that proposes to assert a right to be
indemnified under this Section 10 shall notify the Company or Holdings, as applicable (the
“Indemnifying Party”), promptly after receipt of notice of commencement of any action, suit
or proceeding against such Indemnified Party (an “Indemnified Proceeding”) in respect of
which a claim is to be made under this Section 10, or the incurrence or realization of any
Loss in respect of which a claim is to

27

 

be made under this Section 10, of the commencement
of such Indemnified Proceeding or of such incurrence or realization, enclosing a copy of all
relevant documents, including all papers served and claims made, but the omission to so notify the
applicable Indemnifying Party promptly of any such Indemnified Proceeding or incurrence or
realization shall not relieve (x) such Indemnifying Party from any liability that it may have to
such Indemnified Party under this Section 10 or otherwise, except, as to such Indemnifying
Party’s liability under this Section 10, to the extent, but only to the extent, that such
Indemnifying Party shall have been prejudiced by such omission, or (y) any other indemnitor from
liability that it may have to any Indemnified Party under the Operative Documents.

               (d) Defense of Proceedings. In case any Indemnified Proceeding shall be brought
against any Indemnified Party, it shall notify the applicable Indemnifying Party of the
commencement thereof as provided in Section 10(c), and such Indemnifying Party shall be
entitled to participate in, and provided such Indemnified Proceeding involves a claim solely for
money damages and does not seek an injunction or other equitable relief against the Indemnified
Party and is not a criminal or regulatory action, to assume the defense of, such Indemnified
Proceeding with counsel reasonably satisfactory to such Indemnified Party. After notice from such
Indemnifying Party to
such Indemnified Party of such Indemnifying Party’s election so to assume the defense thereof
and the failure by such Indemnified Party to object to such counsel within five (5) Business Days
following its receipt of such notice, such Indemnifying Party shall not be liable to such
Indemnified Party for legal or other expenses related to such Indemnified Proceedings incurred
after such notice of election to assume such defense except as provided below and except for the
reasonable costs of investigating, monitoring or cooperating in such defense subsequently incurred
by such Indemnified Party reasonably necessary in connection with the defense thereof. Such
Indemnified Party shall have the right to employ its own counsel in any such Indemnified
Proceeding, but the fees and expenses of such counsel shall be at the expense of such Indemnified
Party unless:

                    (i) the employment of counsel by such Indemnified Party at the expense of the applicable
Indemnifying Party has been authorized in writing by such Indemnifying Party;

                    (ii) such Indemnified Party shall have reasonably concluded in its good faith (which
conclusion shall be determinative unless a court determines that such conclusion was not reached
reasonably and in good faith) that there is or may be a conflict of interest between the applicable
Indemnifying Party and such Indemnified Party in the conduct of the defense of such Indemnified
Proceeding or that there are or may be one or more different or additional defenses, claims,
counterclaims, or causes of action available to such Indemnified Party (it being agreed that in any
case referred to in this clause (ii) such Indemnifying Party shall not have the right to
direct the defense of such Indemnified Proceeding on behalf of the Indemnified Party);

                    (iii) the applicable Indemnifying Party shall not have employed counsel reasonably acceptable
to the Indemnified Party, to assume the defense of such Indemnified Proceeding within a reasonable
time after notice of the

28

 

commencement thereof; provided, however, that (A) this
clause (iii) shall not be deemed to constitute a waiver of any conflict of interest that
may arise with respect to any such counsel, and (B) an Indemnified Party may not invoke this
clause (iii) if such Indemnified Party failed to timely object to such counsel pursuant to
the first paragraph of this Section 10(d) above (it being agreed that in any case referred
to in this clause (iii) such Indemnifying Party shall not have the right to direct the
defense of such Indemnified Proceeding on behalf of the Indemnified Party); or

                    (iv) any counsel employed by the applicable Indemnifying Party shall fail to timely commence
or reasonably conduct the defense of such Indemnified Proceeding and such failure has prejudiced
(or is in immediate danger of prejudicing) the outcome of such Indemnified Proceeding (it being
agreed that in any case referred to in this clause (iv) such Indemnifying Party shall not
have the right to direct the defense of such Indemnified Proceeding on behalf of the Indemnified
Party);

in each of which cases the reasonable fees and expenses of counsel for such Indemnified Party shall
be at the expense of such Indemnifying Party. The Indemnifying Person shall be responsible for the
reasonable fees and expenses of only one counsel retained by all Indemnified Parties with respect
to any Indemnified Proceeding, and any additional
counsel shall be retained at the expense of such Indemnified Party, unless counsel for any
Indemnified Party reasonably concludes in good faith (which conclusion shall be determinative
unless a court determines that such conclusion was not reached reasonably and in good faith) that
there is or may be a conflict of interest between such Indemnified Party and one or more other
Indemnified Parties in the conduct of the defense of such Indemnified, in which case the
Indemnifying Party shall be responsible for the reasonable fees and expenses of such additional
counsel.

               (e) Settlement. Without the prior written consent of such Indemnified Party, such
Indemnifying Party shall not settle or compromise, or consent to the entry of any judgment in, any
pending or threatened Indemnified Proceeding, unless such settlement, compromise, consent or
related judgment (i) includes an unconditional release of such Indemnified Party from all liability
for Losses arising out of such claim, action, investigation, suit or other legal proceeding,
(ii) provides for the payment of money damages as the sole relief for the claimant (whether at law
or in equity), (iii) involves no admission of fact adverse to the Indemnified Party or finding or
admission of any violation of law or the rights of any Person by the Indemnified Party, and (iv) is
not in the nature of a criminal or regulatory action. No Indemnified Party shall settle or
compromise, or consent to the entry of any judgment in, any pending or threatened Indemnified
Proceeding (A) in respect of which any payment would result hereunder or under any other Operative
Document, (B) which includes an injunction that will adversely affect any Indemnifying Party,
(C) which involves an admission of fact adverse to the Indemnifying Party or a finding or admission
of any violation of law or the rights of any Person by the Indemnifying Party, or (D) which is in
the nature of a criminal or regulatory action, without the prior written consent of the
Indemnifying Party, such consent not to be unreasonably conditioned, withheld or delayed.

29

 

          Section 11. No Petition. Each of the Company and Holdings covenants and agrees that,
prior to the date which is one year and one day after the expiration of the Purchase Option Period,
it will not institute or join in the institution of any bankruptcy, insolvency, reorganization or
similar proceeding against the Symphony Collaboration. The provisions of this Section 11
shall survive the termination of this Agreement.

          Section 12. Third-Party Beneficiary. Each of the Parties agrees that each Symphony
Fund shall be a third-party beneficiary of this Agreement.

          Section 13. Notices. Any notice, request, demand, waiver, consent, approval or other
communication which is required or permitted to be given to any Party shall be in writing addressed
to the Party at its address set forth below and shall be deemed given (i) when delivered to the
Party personally, (ii) if sent to the Party by facsimile transmission (promptly followed by a
hard-copy delivered in accordance with this Section 13), when the transmitting Party
obtains written proof of transmission and receipt; provided, however, that notwithstanding the
foregoing, any communication sent by facsimile transmission after 5:00 PM (receiving Party’s time)
or not on a Business Day shall not be deemed received until the next Business Day, (iii) when
delivered by next Business Day delivery by a nationally recognized courier service, or (iv) if sent
by registered or certified mail, when received, provided postage and registration or certification
fees are prepaid and delivery is confirmed by a return receipt:

The Company:

OXiGENE, Inc.

230 Third Avenue

Waltham, MA 02451

Attn: Chief Executive Officer

Facsimile: (781) 547-6800

The Symphony Collaboration:

Symphony ViDA, Inc.

7361 Calhoun Place, Suite 325

Rockville, MD 20855

Attn: Charles W. Finn, Ph.D.

Facsimile: (301) 762-6154

Holdings:

Symphony ViDA Holdings LLC

7361 Calhoun Place, Suite 325

Rockville, MD 20855

Attn: Robert L. Smith, Jr.

Facsimile: (301) 762-6154

with copies to:

30

 

Symphony Capital Partners, L.P.

875 Third Avenue, 18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

and

Symphony Strategic Partners, LLC

875 Third Avenue, 18th Floor

New York, NY 10022

Attn: Mark Kessel

Facsimile: (212) 632-5401

or to such other address as such Party may from time to time specify by notice given in the manner
provided herein to each other Party entitled to receive notice hereunder.

          Section 14. Governing Law; Consent to Jurisdiction and Service of Process.

               (a) This Agreement shall be governed by, and construed in accordance with, the laws of the
State of New York; except to the extent that this Agreement pertains to the internal governance of
the Company, the Symphony Collaboration or Holdings, and to such extent this Agreement shall be
governed and construed in accordance with the laws of the State of Delaware.

               (b) Each of the Parties hereby irrevocably and unconditionally submits, for itself and its
property, to the nonexclusive jurisdiction of any New York State court and Delaware State court or
federal court of the United States of America sitting in The City of New York, Borough of Manhattan
or Wilmington, Delaware, and any appellate court from any jurisdiction thereof, in any action or
proceeding arising out of or relating to this Agreement, or for recognition or enforcement of any
judgment, and each of the Parties hereby irrevocably and unconditionally agrees that all claims in
respect of any such action or proceeding may be heard and determined in any such New York State
court, any such Delaware State court or, to the fullest extent permitted by law, in such federal
court. Each of the Parties agrees that a final judgment in any such action or proceeding shall be
conclusive and may be enforced in other jurisdictions by suit on the judgment or in any other
manner provided by law. Nothing in this Agreement shall affect any right that any Party may
otherwise have to bring any action or proceeding relating to this Agreement.

               (c) Each of the Parties irrevocably and unconditionally waives, to the fullest extent it may
legally and effectively do so, any objection that it may now or hereafter have to the laying of
venue of any suit, action or proceeding arising out of or relating to this Agreement in any
New York State or federal court, or any Delaware State or federal court. Each of the Parties
hereby irrevocably waives, to the fullest extent permitted by law, the defense of an inconvenient
forum to the maintenance of such action

31

 

or proceeding in any such court. Each of the parties hereby consents to service of process by
mail.

          Section 15. Waiver of Jury Trial. EACH OF THE PARTIES HERETO IRREVOCABLY WAIVES ALL
RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT
OR OTHERWISE) ARISING OUT OF OR RELATING TO THIS AGREEMENT.

          Section 16. Entire Agreement. This Agreement (including any Annexes, Schedules,
Exhibits or other attachments hereto) constitutes the entire agreement between the Parties with
respect to the matters covered hereby and supersedes all prior and contemporaneous agreements,
correspondence, discussion, and understanding with respect to such matters between the Parties,
excluding the Operative Documents.

          Section 17. Amendment; Successors; Counterparts.

               (a) The terms of this Agreement shall not be altered, modified, amended, waived or
supplemented in any manner whatsoever except by a written instrument signed by each of the Parties.

               (b) Except as set forth in Section 12, nothing expressed or implied herein is intended
or shall be construed to confer upon or to give to any Person, other than the Parties, any right,
remedy or claim under or by reason of this Agreement or of any term, covenant or condition hereof,
and all the terms, covenants, conditions, promises and agreements contained herein shall be for the
sole and exclusive benefit of the Parties and their successors and permitted assigns.

               (c) This Agreement may be executed in one or more counterparts, each of which, when executed,
shall be deemed an original but all of which, taken together, shall constitute one and the same
Agreement.

          Section 18. Specific Performance. The Parties acknowledge that irreparable damage
would result if this Agreement were not specifically enforced, and they therefore agree that the
rights and obligations of the Parties under this Agreement may be enforced by a decree of specific
performance issued by a court of competent jurisdiction. Such a remedy shall, however, not be
exclusive, and shall be in addition to any other remedies which any Party may have under this
Agreement or otherwise. The Parties further acknowledge and agree that a decree of specific
performance may not be an available remedy in all circumstances.

          Section 19. Severability. If any term or other provision of this Agreement is
invalid, illegal or incapable of being enforced by any rule of law or public policy, all other
conditions and provisions of this Agreement shall nevertheless remain in full force and effect so
long as the economic or legal substance of the transactions contemplated hereby is not affected in
a manner materially adverse to either party. Upon such determination that any term or other
provision is invalid, illegal or incapable of

32

 

being enforced, the parties hereto shall negotiate in good faith to modify this Agreement so
as to effect the original intent of the parties as closely as possible in an acceptable manner to
the end that the transactions contemplated hereby are fulfilled to the extent possible.

          Section 20. Tax Reporting. The Parties acknowledge and agree that, for all federal
and state income tax purposes:

               (a) (i) Holdings shall be treated as the owner of all the Equity Securities of the Symphony
Collaboration prior to the consummation of the Purchase Option; (ii) the Purchase Option shall be
treated as an option to acquire all the Equity Securities of the Symphony Collaboration; (iii) the
Option Premium Shares shall be treated as an option premium payable in respect of the grant of the
Purchase Option; and (iv) the Symphony Collaboration shall be treated as the owner of all the
Licensed Intellectual Property and shall be entitled to all deductions claimed under Section 174 of
the Code in respect of the Licensed Intellectual Property to the extent of the amounts funded by
the Symphony Collaboration (which, for the avoidance of doubt, shall not preclude the Company from
claiming deductions under Section 174 of the Code to which the Company is otherwise entitled); and

               (b) No Party shall take any tax position inconsistent with any position described in
Section 20(a) above, except (i) in the event of a “determination” (as defined in
Section 1313 of the Code) to the contrary, or (ii) in the event either of the Parties receives an
opinion of counsel to the effect that there is no reasonable basis in law for such a position or
that a tax return cannot be prepared based on such a position without being subject to substantial
understatement penalties; provided, however, that in the case of the Company, such
counsel shall be reasonably satisfactory to Holdings.

[SIGNATURES FOLLOW ON NEXT PAGE]

33

 

     IN WITNESS WHEREOF, the parties hereto have signed this Agreement as of the day and year first
above written.

	 	 	 	 	 
	 	OXiGENE, INC.

 	 
	 	By:  	     /s/ John A. Kollins
 	 
	 	 	Name:  	John A. Kollins 	 
	 	 	Title:  	Chief Operating Officer 	 
	 

	 	 	 	 	 
	 	 	SYMPHONY ViDA HOLDINGS LLC
	 
	 	 	 	 
	 

	 	By:
	 	Symphony Capital Partners, L.P.,
	 

	 	 	 	its Manager
	 
	 	 	 	 
	 

	 	By:
	 	Symphony Capital GP, L.P.,
	 

	 	 	 	its general partner
	 
	 	 	 	 
	 

	 	By:
	 	Symphony GP, LLC,
	 

	 	 	 	its general partner

	 	 	 	 	 
	 	 	 
	 	By:  	                            /s/ Mark Kessel
 	 
	 	 	Name:  	Mark Kessel 	 
	 	 	Title:  	Managing Member 	 
	 

	 	 	 	 	 
	 	SYMPHONY ViDA, INC.

 	 
	 	By:  	     /s/ Mark Kessel
 	 
	 	 	Name:  	Mark Kessel 	 
	 	 	Title:  	Chairman of the Board 	 
	 

[Signature Page to Purchase Option Agreement]

 

 

ANNEX A

CERTAIN DEFINITIONS

See attached.

Annex A to Purchase Option Agreement

 

 

ANNEX B

FORM OF CONVERTIBLE NOTE

			
	 	 	 
	$                    
	 	New York, NY

                    , 20___

     FOR VALUE RECEIVED, the undersigned, OXiGENE, Inc., a Delaware corporation (the
“Company”), hereby unconditionally promises to pay to the order of Symphony ViDA Holdings
LLC, a Delaware limited liability company (“Holdings”), in lawful money of the United
States of America and in immediately available funds, the principal sum of
$[                    ]1. This Convertible Term Note (this “Convertible Note”) is issued in
accordance with the provisions of that certain Purchase Option Agreement, dated as of October 1,
2008, by and among the Company, Holdings and Symphony ViDA, Inc. (as amended, supplemented or
otherwise modified from time to time, the “Purchase Option Agreement”) and is entitled to
the benefits of the Purchase Option Agreement and the other Operative Documents (as defined
therein). All capitalized terms used herein (which are not otherwise specifically defined herein)
shall be used in this Convertible Note as defined in the Purchase Option Agreement, including
Annex A attached thereto.

          Section 21. The outstanding principal balance of this Convertible Note (the “Convertible Term
Loan”) (together with any unpaid interest thereon) shall be due and payable in full on
[                    ]2 (the “Maturity Date”); provided, however, that the principal amount
(together with any unpaid interest thereon) payable on the Maturity Date may be reduced in
connection with an exercise by the Company of its Conversion Right (as defined below). The
outstanding principal balance of this Convertible Note may be prepaid in cash at any time without
premium or penalty.

          Section 22. The Company promises to pay interest from the date hereof until payment in full or
conversion hereof on the unpaid principal balance of the Convertible Term Loan at a rate ten
percent (10%) per annum. Interest on the unpaid principal balance of the Convertible Term Loan
shall be payable in full on the earlier of (i) the date on which the outstanding principal balance
of this Convertible Note is paid in full and (ii) the Maturity Date. Interest as aforesaid shall
be charged for the actual number of days elapsed over a year consisting of three hundred sixty
(360) days on the actual daily outstanding balance hereof; provided; that interest calculations
shall include the date of funding of the Convertible Term Loan, but shall exclude the Maturity
Date. In the event that the Company exercises its Conversion Right, the unpaid outstanding
principal balance of the Convertible Term Loan (together with any unpaid interest thereon) shall be

 

			
	1	 	Insert in dollar terms the portion of the Purchase
Price which is to be paid with this Convertible Note.
	 
	2	 	Insert date that is one Business Day following the day
on which the Company Common Stock is priced pursuant to Section 4(b)(ii).

Annex B to Purchase Option Agreement

 

 

reduced by the Converted Amount (as defined below), and such Reduction shall be notified to
Holdings in writing.

          Section 23. Upon and after the occurrence of an Event of Default (as defined below), the
Convertible Term Loan may be declared, and immediately shall become, due and payable in cash
without demand, notice or legal process of any kind. An “Event of Default” shall occur if:

               (a) at any time following the tenth (10th) consecutive Business Day that the number of
authorized and outstanding shares of the Company’s common stock, par value $0.01 per share (the
“Company Common Stock”) is less than the number of shares of Company Common Stock that
Holdings would be entitled to receive upon a conversion of the full Conversion Amount of this
Convertible Note;

               (b) the Company’s failure to pay to Holdings any amounts aggregating in excess of $10,000 when
and as due under the Operative Documents;

               (c) the Company, pursuant to any bankruptcy or insolvency law, (A) commences a voluntary case,
(B) consents to the entry of an order for relief against it in an involuntary case, (C) consents to
the appointment of a receiver, trustee, assignee, liquidator or similar official, (D) makes a
general assignment for the benefit of its creditors or (E) admits in writing that it is generally
unable to pay its debts as they become due;

               (d) a court of competent jurisdiction enters an order or decree under any bankruptcy or
insolvency law that (A) is for relief against the Company in an involuntary case, (B) appoints a
receiver, trustee, assignee, liquidator or similar official for the Company or (C) orders the
liquidation of the Company;

               (e) a final judgment or judgments for the payment of money aggregating in excess of $500,000
are rendered against the Company and which judgments are not, within sixty (60) days after the
entry thereof, bonded, discharged or stayed pending appeal, or are not discharged within sixty (60)
days after the expiration of such stay; provided, however, that any judgment which is covered by
insurance or an indemnity from a creditworthy party shall not be included in calculating the
$500,000 amount set forth above so long as the Company provides Holdings with a written statement
from such insurer or indemnity provider (which written statement shall be reasonably satisfactory
to Holdings) to the effect that such judgment is covered by insurance or an indemnity and the
Company will receive the proceeds of such insurance or indemnity within thirty (30) days of the
issuance of such judgment; or

               (f) the Company breaches in any material respect any representation, warranty, covenant or
other term or condition of this Convertible Note or any Operative Document, except, in the case of
a breach of a covenant or other term or condition of this Convertible Note or any Operative
Document which is curable, only if such breach continues for a period of at least ten (10)
consecutive Business Days.

Annex B to Purchase Option Agreement

 

 

          Section 24. This Convertible Note shall be convertible into fully paid and nonassessable
shares of Company Common Stock, on the terms and subject to the conditions set forth in this
Section 4.

          (a) Conversion Right. At the Maturity Date, at its option, the Company shall be
entitled to convert all or any portion of the outstanding principal balance of the Convertible Term
Loan (together with any unpaid interest thereon) into duly authorized, validly issued, fully paid
and nonassessable shares of Company Common Stock in accordance with Section 4(c), at the
Conversion Rate (as defined below) (the “Conversion Right”). No fractional shares of
Company Common Stock shall be issuable upon exercise or conversion of this Convertible Note and the
number of shares of Company Common Stock to be issued shall be rounded down to the nearest whole
share. If a fractional share interest arises upon any conversion of this Convertible Note, the
Company shall eliminate such fractional share interest by paying Holdings the amount computed by
multiplying the fractional interest by the fair market value of a share of Company Common Stock.
The Company shall pay any and all taxes that may be payable with respect to the issuance and
delivery of the Company Common Stock upon conversion of all or any portion of the outstanding
principal balance of the Convertible Term Loan.

          (b) Conversion Rate. The number of shares of Company Common Stock issuable upon
conversion of all or any portion of the outstanding principal balance of the Convertible Term Loan
(together with any unpaid interest thereon) pursuant to Section 4(a) shall be determined by
dividing (x) the Conversion Amount by (y) the Conversion Price then in effect (the “Conversion
Rate”).

     (i) “Conversion Amount” means the dollar value of that portion of the
outstanding principal amount of the Convertible Term Loan (together with any unpaid
interest thereon) to be converted into Company Common Stock.

     (ii) “Conversion Price” means the closing bid price of Company Common
Stock on [                    ]3, subject to adjustment as provided herein.

          (c) Mechanics of Conversion. To convert the Conversion Amount into Company Common
Stock on the Maturity Date, the Company shall transmit by facsimile (or otherwise deliver), for
receipt on or prior to 12:00 p.m., New York time, on the date that is fifteen (15) Business Days
prior to the Maturity Date, a copy of an executed notice of conversion in the form attached hereto
as Exhibit A (the “Conversion Notice”) to Holdings. On or before the second (2nd)
Business Day following the date of receipt of a Conversion Notice, Holdings shall transmit by
facsimile a confirmation of receipt of such Conversion Notice to the Company. On the Maturity
Date, the Company shall issue and deliver to the address as specified in the Conversion

 

			
	3	 	Insert the date that is six months following the day on
which Holdings or its Affiliates last sold Company Common Stock or, if such day
is not a Business Day, the date of the next following Business Day.

Annex B to Purchase Option Agreement

 

 

Notice, a certificate, registered in the name of Holdings or its designee, for the number of
shares of Company Common Stock to which Holdings shall be entitled. The Person or Persons entitled
to receive the Company Common Stock issuable upon a conversion of this Convertible Note shall be
treated for all purposes as the record holder or holders of such Company Common Stock on the
Conversion Date. In the event of a partial conversion of this Convertible Note pursuant hereto,
the balance of the principal amount payable hereunder (together with any unpaid interest thereon)
shall be paid in full in cash on the Maturity Date.

               (d) Rights upon Other Corporate Events. In addition to and not in substitution for
any other rights hereunder or under the Operative Documents, prior to the consummation of any
merger, acquisition or consolidation pursuant to which holders of Company Common Stock are entitled
to receive securities or other assets with respect to or in exchange for Company Common Stock (a
“Corporate Event”), the principal amount payable hereunder (together with any unpaid
interest thereon) shall be paid in full in cash on the effective date of such Corporate Event (but
in no event after the Maturity Date).

               (e) Reclassification; Exchange; Combinations or Substitution. Upon any
reclassification, exchange, substitution, or other event that results in a change of the number
and/or class of the securities issuable upon exercise of the Conversion Right (other than stock
splits and reverse stock splits), the principal amount payable hereunder (together with any unpaid
interest thereon) shall be paid in full in cash on the effective date of such reclassification,
exchange, substitution or other event (but in no event after the Maturity Date).

               (f) Representations and Warranties Regarding Conversion. The Company hereby restates
the representations and warranties set forth in Section 4.02 of the Stock and Warrant
Purchase Agreement, dated as of October 1, 2008, between Holdings and the Company (the “Stock
and Warrant Purchase Agreement”), respectively, as of the date hereof.

               (g) Reservation of Shares. The Company shall reserve sufficient shares of Company
Common Stock out of its authorized shares to ensure that Shares will be immediately available upon
exercise of the Conversion Right.

               (h) Miscellaneous.

                    (i) Term. The Conversion Right is exercisable in whole or in part on the Maturity
Date. If the Conversion Right is exercised in part on the Maturity Date, the balance of the
principal and interest due pursuant to this Convertible Note shall be due and payable in cash on
the Maturity Date.

                    (ii) Legends. The Company Common Stock (and the securities issuable, directly or
indirectly, upon conversion of the Company Common Stock, if any) shall be imprinted with a legend
in substantially the form set forth in Section 6.02 of the Stock and Warrant Purchase
Agreement.

Annex B to Purchase Option Agreement

 

 

                    (iii) Compliance with Securities Laws on Transfer. The Company Common Stock issuable
upon exercise of the Conversion Right shall be subject to the restrictions on transfer set forth in
Article VI of the Stock and Warrant Purchase Agreement.

          Section 25. Presentment, demand, protest and notice of presentment, demand, nonpayment and
protest are each hereby waived by the Company.

          Section 26. No waiver by Holdings of any one or more defaults by the undersigned in the
performance of any of its obligations under this Convertible Note shall operate or be construed as
a waiver of any future default or defaults, whether of a like or different nature, or as a waiver
of any obligation of the Company under the Operative Documents.

          Section 27. No provision of this Convertible Note may be amended, waived or otherwise modified
unless such amendment, waiver or other modification is in writing and is signed or otherwise
approved by the Company and Holdings.

          Section 28. THIS CONVERTIBLE NOTE SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN
ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO CONFLICTS OF LAW PRINCIPLES.

          Section 29. Whenever possible each provision of this Convertible Note shall be interpreted in
such manner as to be effective and valid under applicable law, but in case any provision of or
obligation under this Convertible Note shall be invalid, illegal or unenforceable in any
jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations,
or of such provision or obligation in any other jurisdiction, shall not in any way be affected or
impaired thereby.

          Section 30. Whenever in this Convertible Note reference is made to Holdings or the Company,
such reference shall be deemed to include, as applicable, a reference to their respective
successors and assigns. The provisions of this Convertible Note shall be binding upon the Company
and its successors and assigns, and shall inure to the benefit of Holdings and its successors and
assigns.

          Section 31. In addition to and without limitation of any of the foregoing, this Convertible
Note and the Company Common Stock issuable pursuant to the Conversion Right shall be subject to the
terms and conditions of the Purchase Option Agreement, the Stock and Warrant Purchase Agreement and
the other Operative Documents.

[Remainder of Page Intentionally Left Blank]

Annex B to Purchase Option Agreement

 

 

     IN WITNESS WHEREOF, the Company has caused this Convertible Note to be executed by its duly
authorized officer as of the day and year first above written.

	 	 	 	 	 
	 	OXiGENE, INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

[Signature Page to Convertible Note]

Annex B to Purchase Option Agreement

 

 

Exhibit A

OXiGENE, INC.

CONVERSION NOTICE

          Reference is made to the Convertible Term Note (the “Convertible Note”) issued to the
undersigned by OXiGENE, Inc. (the “Company”). In accordance with and pursuant to the
Convertible Note, the undersigned hereby elects to convert the Conversion Amount (as defined in the
Convertible Note) of the Convertible Note indicated below into the Company’s common stock, par
value $0.01 per share (the “Company Common Stock”), as of the date specified below.

     1. The Company elects to convert the attached Convertible Note into Company Common Stock in
the manner specified in the Convertible Note. This conversion is exercised for the following
Conversion Amount: $                    .

     2. The Company shall, on the Maturity Date, issue a certificate representing the Company
Common Stock for a number of shares to be determined on the Maturity Date pursuant to Section
4(b) of the Convertible Note in the name specified below:

Symphony ViDA Holdings LLC

c/o Symphony Capital Partners, L.P.

875 Third Avenue, 18th Floor

New York, NY 10022

Attn: Mark Kessel

     3. By its execution below and for the benefit of Holdings, the Company hereby restates each
of the representations and warranties in Section 4.02 of the Stock and Warrant Purchase
Agreement as of the date hereof.

	 	 	 	 	 	 	 
	 	 	OXiGENE, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 
	 
	 	 	 	 	 	 
	 

	 	Date:	 	 	 	 
	 

	 	 	 	 	 	 

Annex B to Purchase Option Agreement

 

 

EXHIBIT 1

PURCHASE OPTION EXERCISE NOTICE

                    , 20__

Attention:                     

Ladies and Gentlemen:

     Reference is hereby made to that certain Purchase Option Agreement dated as of October 1, 2008
(the “Purchase Option Agreement”), by and among OXiGENE, Inc., a Delaware corporation (the
“Company”), Symphony ViDA Holdings LLC, a Delaware limited liability company, and Symphony
ViDA, Inc., a Delaware corporation. Capitalized terms used herein and not otherwise defined herein
shall have the meanings assigned thereto in the Purchase Option Agreement.

     Pursuant to Section 2(a) of the Purchase Option Agreement, the Company hereby
irrevocably notifies you that it hereby exercises the Purchase Option.

     Subject to the terms set forth therein, the Company hereby affirms the representations and
warranties set forth in Section 3(a) of the Purchase Option Agreement, as of the date
hereof.

     The Company estimates that the Purchase Option Closing Date will be                     , 20___.

     The Purchase Price will be $                    , subject to adjustment if the Purchase Option Closing Date
occurs later than the estimated date set forth above.

     Subject to the limitations set forth in Section 2(c) of the Purchase Option Agreement,
the Company intends to pay ___% of the Purchase Price in Company Common Stock. The number of
shares estimated to be transferred at such Purchase Price will be                      shares, based on a per
share valuation of $                     calculated as of the closing of the preceding trading day of the
Company Common Stock. This represents ___% of the total amount of Company Common Stock issued and
outstanding as of the date hereof.

	 	 	 	 	 
	 	Very truly yours,

OXiGENE, INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

Annex B to Purchase Option Agreementexv10w5

Exhibit 10.5

EXECUTION COPY

      

REGISTRATION RIGHTS AGREEMENT

between

OXiGENE, INC.

and

SYMPHONY ViDA HOLDINGS LLC

 

Dated as of October 1, 2008

 

 

 

 

Table of Contents

	 	 	 	 	 
	Section	 	Page	 
	Section 1. Definitions
	 	 	1	 
	 
	Section 2. Registration
	 	 	3	 
	 
	Section 3. Related Obligations
	 	 	5	 
	 
	Section 4. Obligations of the Investor(s)
	 	 	9	 
	 
	Section 5. Expenses of Registration
	 	 	10	 
	 
	Section 6. Indemnification
	 	 	10	 
	 
	Section 7. Contribution
	 	 	14	 
	 
	Section 8. Reports Under The Exchange Act
	 	 	15	 
	 
	Section 9. Assignment of Registration Rights
	 	 	15	 
	 
	Section 10. Amendment
	 	 	16	 
	 
	Section 11. Miscellaneous
	 	 	16	 

Exhibit A — Form of Selling Stockholder Questionnaire

i

 

REGISTRATION RIGHTS AGREEMENT

     REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of October 1, 2008, by and
between OXiGENE, INC., a Delaware corporation (the “Company”), and SYMPHONY ViDA HOLDINGS
LLC, a Delaware limited liability company (together with its permitted successors, assigns and
transferees, “Holdings”).

RECITALS:

     WHEREAS, in connection with the exercise by the Company of the Purchase Option under the
Purchase Option Agreement, by and among the Company, Holdings and Symphony ViDA, Inc., a Delaware
corporation (the “Symphony Collaboration”), of even date herewith (the “Purchase Option
Agreement”), the Company may elect to issue shares of the Company’s common stock, par value
$0.01 per share (“Company Common Stock”) (such shares of Company Common Stock when and if
issued, the “Purchase Option Shares”) to Holdings in partial payment of the Purchase Price
in accordance with the terms of the Purchase Option Agreement;

     WHEREAS, in connection with the Stock and Warrant Purchase Agreement by and between the
parties hereto of even date herewith (the “Stock and Warrant Purchase Agreement”), the
Company has agreed, upon the terms and subject to the conditions of the Stock and Warrant Purchase
Agreement, to issue and sell to Holdings the Direct Investment Shares, the Option Premium Shares,
the Additional Investment Shares, the Non-IV Shares, the Direct Investment Warrant, the Additional
Investment Warrant and the Non-IV Warrant, which warrants will be exercisable to purchase shares of
Company Common Stock in accordance with the terms of such warrants; and

     WHEREAS, to induce Holdings to execute and deliver the Purchase Option Agreement and the Stock
and Warrant Purchase Agreement, the Company has agreed to provide certain registration rights under
the Securities Act of 1933, as amended (the “Securities Act”), and applicable state
securities laws with respect to the shares of Company Common Stock to be issued to Holdings;

     NOW, THEREFORE, in consideration of the premises and the mutual covenants contained herein and
other good and valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, the Company and Holdings (the “Parties”) hereby agree as follows:

     Section 1. Definitions.

          (a) Capitalized terms used but not defined herein are used as defined in the Purchase Option
Agreement (including Annex A thereto).

          (b) As used in this Agreement, the following terms shall have the following meanings:

	 	 	 	 	 	 	 
	 

	 	 		 	 	Registration Rights Agreement

 

 

               (i) “Additional Registrable Securities” means (i) the Additional Investment Shares,
and (ii) any Company Common Stock issued with respect to the Additional Investment Shares as a
result of any stock split, stock dividend, recapitalization, exchange or similar event or
otherwise.

               (ii) “Company Warrants” has the meaning set forth in Section 2.02 of the
Holdings LLC Agreement.

               (iii) “Effective Registration Date” means the date that the Registration Statement (as
defined below) is first declared effective by the SEC.

               (iv) “Investor(s)” means Holdings, any transferee or assignee thereof to whom Holdings
assigns its rights under this Agreement and who agrees to become bound by the provisions of this
Agreement in accordance with Section 9 and any transferee or assignee thereof to whom a
transferee or assignee assigns its rights under this Agreement and who agrees to become bound by
the provisions of this Agreement in accordance with Section 9.

               (v) “Non-IV Registrable Securities” means (i) the Non-IV Shares, and (ii) any Company
Common Stock issued with respect to the Non-IV Shares as a result of any stock split, stock
dividend, recapitalization, exchange or similar event or otherwise.

               (vi) “Purchase Option Related Registrable Securities” means (i) the Purchase Option
Shares, and (ii) any Company Common Stock issued with respect to the Purchase Option Shares as a
result of any stock split, stock dividend, recapitalization, exchange or similar event or
otherwise.

               (vii) “register,” “registered,” and “registration” refer to a
registration effected by preparing and filing one or more Registration Statements in compliance
with the Securities Act and pursuant to Rule 415, and the declaration or ordering of effectiveness
of such Registration Statement(s) by the SEC.

               (viii) “Registrable Securities” means, collectively, the Share Purchase Related
Registrable Securities, the Purchase Option Related Registrable Securities, the Additional
Registrable Securities, the Non-IV Registrable Securities and the Warrant Related Registrable
Securities; provided, however, that such securities will cease to be Registrable Securities
on the earlier of (A) the date as of which the Investor(s) may sell such securities without
restriction pursuant to Rule 144(b) (or successor thereto) promulgated under the Securities Act, or
(B) the date on which the Investor(s) shall have sold all such securities.

               (ix) “Registration Statement” means a registration statement or registration
statements of the Company filed under the Securities Act covering the Registrable Securities.

               (x) “Rule 144” has the meaning set forth in Section 8 of this Agreement.

 
	 	 	 	 	 	 	 
	 

	 	 	2	 	 	Registration Rights Agreement

 

 

               (xi) “Rule 415” means Rule 415 under the Securities Act or any successor rule
providing for offering securities on a continuous or delayed basis.

               (xii) “Share Purchase Related Registrable Securities” means (i) the Direct Investment
Shares, (ii) the Option Premium Shares, and (iii) any shares of capital stock issued or issuable
with respect to the Direct Investment Shares or Option Premium Shares as a result of any stock
split, stock dividend, recapitalization, exchange or similar event or otherwise.

               (x) “Warrant Related Registrable Securities” means (i) the Warrant Shares, (ii) the
shares issuable upon exercise of the Additional Investment Warrant, (iii) the shares issuable upon
exercise of the Non-IV Warrant and (iv) any shares of capital stock issued or issuable with respect
to the foregoing as a result of any stock split, stock dividend, recapitalization, exchange or
similar event or otherwise.

          Section 2. Registration. Right to Registration.

               (i) Purchase Option Related Registration. In the event the Company elects to exercise
the Purchase Option as set forth in the Purchase Option Agreement, and in so doing elects to issue
Purchase Option Related Registrable Securities, the Company shall prepare and, in accordance with
Section 2(a)(ii)(B) of the Purchase Option Agreement, file with the SEC a Registration
Statement on Form S-3 covering the resale of the Purchase Option Related Registrable Securities
(the obligations of the Company under this subsection (a)(i) being subject to Section 2(b) below).
The Registration Statement prepared pursuant hereto shall register for resale that number of shares
of Company Common Stock equal to the number of Purchase Option Related Registrable Securities as
would be issued pursuant to the terms of the Purchase Option Agreement, subject to adjustment as
provided in Sections 2(c) and 2(d). The Company shall use commercially reasonable efforts
to have the Registration Statement declared effective by the SEC as soon as practicable (and in any
event within 120 days) following the Purchase Option Exercise Date.

               (ii) Share Purchase Related Registration. The Company shall prepare, and, as soon as
practicable but in no event later than forty-five (45) days after the Closing Date, file with the
SEC a Registration Statement on Form S-3 covering the resale of all of the Share Purchase Related
Registrable Securities (the obligations of the Company under this subsection (a)(ii) being subject
to Section 2(b) below). The Registration Statement prepared pursuant hereto shall register for
resale at least that number of shares of Company Common Stock equal to the number of Share Purchase
Related Registrable Securities as of the trading day immediately preceding the date the
Registration Statement is initially filed with the SEC, subject to adjustment as provided in
Sections 2(c) and 2(d). The Company shall use commercially reasonable efforts to
have the Registration Statement declared effective by the SEC as soon as
practicable (and in any event within 120 days) following the Closing Date, unless otherwise
agreed.

	 	 	 	 	 	 	 
	 

	 	 	3	 	 	Registration Rights Agreement

 

 

               (iii) Warrant Related Registration. The Company shall prepare, and, as soon as
practicable but in no event later than forty-five (45) days after the Closing Date, file with the
SEC a Registration Statement on Form S-3 covering the resale of all of the Warrant Related
Registrable Securities (the obligations of the Company under this subsection (a)(iii) being subject
to Section 2(b) below). The Registration Statement prepared pursuant hereto shall register for
resale at least that number of shares of Company Common Stock equal to the number of Warrant
Related Registrable Securities as of the trading day immediately preceding the date the
Registration Statement is initially filed with the SEC, subject to adjustment as provided in
Sections 2(c) and 2(d). The Company shall use commercially reasonable efforts to
have the Registration Statement declared effective by the SEC as soon as practicable (and in any
event within 120 days) following the Closing Date.

               (iv) Additional Share Related Registration. The Company shall prepare, and, as soon
as practicable but in no event later than forty-five (45) days after the Additional Closing Date,
file with the SEC a Registration Statement on Form S-3 covering the resale of all of the Additional
Registrable Securities (the obligations of the Company under this subsection (a)(iv) being subject
to Section 2(b) below). The Registration Statement prepared pursuant hereto shall register for
resale at least that number of shares of Company Common Stock equal to the number of Additional
Registrable Securities as of the trading day immediately preceding the date the Registration
Statement is initially filed with the SEC, subject to adjustment as provided in
Sections 2(c) and 2(d). The Company shall use commercially reasonable efforts to
have the Registration Statement declared effective by the SEC as soon as practicable (and in any
event within 120 days) following the Additional Closing Date.

               (v) Non-IV Share Related Registration. The Company shall prepare, and, as soon as
practicable but in no event later than forty-five (45) days after the Non-IV Closing Date, file
with the SEC a Registration Statement on Form S-3 covering the resale of all of the Non-IV
Registrable Securities (the obligations of the Company under this subsection (a)(v) being subject
to Section 2(b) below). The Registration Statement prepared pursuant hereto shall register for
resale at least that number of shares of Company Common Stock equal to the number of Non-IV
Registrable Securities as of the trading day immediately preceding the date the Registration
Statement is initially filed with the SEC, subject to adjustment as provided in
Sections 2(c) and 2(d). The Company shall use commercially reasonable efforts to
have the Registration Statement declared effective by the SEC as soon as practicable (and in any
event within 120 days) following the Non-IV Closing Date.

          (b) Ineligibility for Form S-3. In the event that Form S-3 is not available for the
registration of the resale of Registrable Securities hereunder, the Company shall (i) register the
resale of the Registrable Securities on another appropriate form reasonably acceptable to Holdings
(which acceptable forms shall include Form S-1) (in the case of the resale of Purchase Option
Related Registrable Securities, in accordance
with Section 2(a)(ii)(B) of the Purchase Option Agreement); and (ii) undertake to
register the Registrable Securities on Form S-3 as soon as such form is available; provided
that the Company shall maintain the effectiveness of the Registration Statement then in effect

	 	 	 	 	 	 	 
	 

	 	 	4	 	 	Registration Rights Agreement

 

 

until such time as a Registration Statement on Form S-3 covering the Registrable Securities has
been declared effective by the SEC.

          (c) Sufficient Number of Shares Registered. In the event the number of shares
available under a Registration Statement filed pursuant to Section 2(a) is insufficient to
cover all of the Registrable Securities required to be covered by such Registration Statement, the
Company shall amend the applicable Registration Statement, or file a new Registration Statement (on
the short form available therefor, if applicable), or both, so as to cover at least 100% of the
number of such Registrable Securities as of the trading day immediately preceding the date of the
filing of such amendment or new Registration Statement (subject to adjustment as provided in
Section 2(d)), in each case, as soon as practicable, but in any event not later than thirty
(30) days after the Company becomes aware of the necessity therefor. The Company shall use
commercially reasonable efforts to cause such amendment and/or new Registration Statement to become
effective as soon as practicable following the filing thereof. For purposes of the foregoing
provision, the number of shares available under a Registration Statement shall be deemed
“insufficient to cover all of the Registrable Securities” if at any time the number of shares of
Company Common Stock available for resale under such Registration Statement is less than the number
of Registrable Securities. The calculation set forth in the foregoing sentence shall be made
without regard to any limitations on the exercise of the Company Warrants and such calculation
shall assume that the Company Warrants are then exercisable into shares of Company Common Stock

          (d) No Deemed Breach. The Company shall not be deemed to have breached its obligations
under this Agreement to have any Registration Statement required by this Agreement declared
effective by the SEC within a particular time frame in the event that the failure to have such
Registration Statement declared effective within a particular time frame results from the SEC
characterizing the offering of the shares of Company Common Stock under such Registration Statement
by the Investor(s) as a primary issuance of such shares by the Company rather than a secondary
offering pursuant to a resale prospectus; provided that, no such time frame shall be extended to
more than 240 days from its original starting date.

     Section 3. Related Obligations. At such time as the Company is obligated to file a
Registration Statement with the SEC pursuant to Section 2(a), (b) or (c),
the Company will use commercially reasonable efforts to effect the registration of the Registrable
Securities in accordance with the intended method of disposition thereof and, pursuant thereto
(except at such times as the Company may be required to suspend the use of a prospectus forming a
part of the Registration Statement pursuant to Section 3(1), at which time the Company’s
obligations under Sections 3(a), (b), (c), (d), (i) and
(k) may also be suspended, as required), the Company shall have the following obligations:

          (a) The Company shall keep each Registration Statement effective pursuant to Rule 415 at all
times until the earlier of (i) the date as of which the Investor(s) may sell all of the Registrable
Securities covered by such Registration Statement without restriction pursuant to Rule 144(b) (or
successor thereto) promulgated under the Securities Act, or (ii) the date on which the Investor(s)
shall have sold all the

	 	 	 	 	 	 	 
	 

	 	 	5	 	 	Registration Rights Agreement

 

 

Registrable Securities covered by such Registration Statement, but in no
event for a period of less than one year from the Closing Date (the “Registration Period”).

          (b) The Company shall prepare and file with the SEC such amendments (including post-effective
amendments) and supplements to a Registration Statement and the prospectus used in connection with
such Registration Statement as may be necessary to keep such Registration Statement effective at
all times during the Registration Period, and, during such period, comply with the provisions of
the Securities Act with respect to the disposition of all Registrable Securities of the Company
covered by such Registration Statement until such time as all of such Registrable Securities shall
have been disposed of in accordance with the intended methods of disposition by the seller or
sellers thereof as set forth in such Registration Statement. In the case of amendments and
supplements to a Registration Statement which are required to be filed pursuant to this Agreement
(including pursuant to this Section 3(b)) by reason of the Company filing a report on Form
10-K, Form 10-Q or Form 8-K or any analogous report under the Exchange Act, the Company shall have
incorporated such report by reference into such Registration Statement, if applicable, or shall
file such amendments or supplements with the SEC on the same day on which the Exchange Act report
is filed which created the requirement for the Company to amend or supplement such Registration
Statement.

          (c) The Company shall furnish to each Investor whose Registrable Securities are included in
any Registration Statement, without charge, (i) promptly after the same is prepared and filed with
the SEC, at least one (1) copy of such Registration Statement and any amendment(s) thereto,
including financial statements and schedules, and each preliminary prospectus; (ii) upon the
effectiveness of any Registration Statement, ten (10) copies of the prospectus included in such
Registration Statement and all amendments and supplements thereto (or such other number of copies
as such Investor may reasonably request); and (iii) such other documents, including copies of any
preliminary or final prospectus, as such Investor may reasonably request from time to time in order
to facilitate the disposition of the Registrable Securities owned by such Investor.

          (d) The Company shall use commercially reasonable efforts to (i) register and qualify, unless
an exemption from registration and qualification applies, the resale by Investor(s) of the
Registrable Securities covered by a Registration Statement under such other securities or “blue
sky” laws of such jurisdictions in the United States as Investor(s) reasonably request;
(ii) prepare and file in those jurisdictions such amendments (including post-effective amendments)
and supplements to such registrations and qualifications as may be necessary to maintain the
effectiveness thereof during the Registration Period; and (iii) take such other actions as may be
necessary to maintain such registrations and qualifications in effect at all times during the
Registration
Period; provided, however, that the Company shall not be required in
connection therewith or as a condition thereto to (x) qualify to do business in any jurisdiction
where it would not otherwise be required to qualify but for this Section 3(d), (y) subject
itself to general taxation in any such jurisdiction, or (z) file a general consent to service of
process in any such jurisdiction. The Company shall promptly notify each Investor who holds

	 	 	 	 	 	 	 
	 

	 	 	6	 	 	Registration Rights Agreement

 

 

Registrable Securities of the receipt by the Company of any notification with respect to the
suspension of the registration or qualification of any of the Registrable Securities for sale under
the securities or “blue sky” laws of any jurisdiction in the United States or its receipt of actual
notice of the initiation or threatening of any proceeding for such purpose.

          (e) The Company shall notify each Investor in writing of the happening of any event, as
promptly as practicable after becoming aware of such event, as a result of which the prospectus
included in a Registration Statement, as then in effect, includes an untrue statement of a material
fact or omission to state a material fact required to be stated therein or necessary to make the
statements therein, in the light of the circumstances under which they were made, not misleading,
and, subject to Section 3(l) hereof, promptly prepare a supplement or amendment to such
Registration Statement to correct such untrue statement or omission. The Company shall also
promptly notify each Investor in writing when a prospectus or any prospectus supplement or
post-effective amendment has been filed, and when a Registration Statement or any post-effective
amendment has become effective.

          (f) The Company shall use commercially reasonable efforts to prevent the issuance of any stop
order or other suspension of effectiveness of a Registration Statement, or the suspension of the
qualification of any of the Registrable Securities for sale in any jurisdiction and, if such an
order or suspension is issued, to obtain the withdrawal of such order or suspension at the earliest
possible moment.

          (g) In the event that any Investor is deemed to be an “underwriter” with respect to the
Registrable Securities, upon the written request of such Investor in connection with such
Investor’s due diligence requirements, if any, the Company shall make available for inspection
during normal business hours by (i) such Investor, and (ii) any legal counsel, accountants or other
agents retained by the Investor (collectively, “Inspectors”), all pertinent financial and
other records, and pertinent corporate documents and properties of the Company (collectively,
“Records”), as shall be reasonably deemed necessary by each Inspector, and cause the
Company’s officers, directors and employees to supply all information which any Inspector may
reasonably request; provided, however, that each Inspector and such Investor shall
agree in writing to hold in strict confidence and shall not make any disclosure (except with
respect to an Inspector, to the relevant Investor) or use of any Record or other information which
the Company determines in good faith to be confidential, and of which determination the Inspectors
are so notified, unless the release of such Records is ordered pursuant to a final, non-appealable
subpoena or order from a court or government body of competent jurisdiction. Each Investor agrees
that it shall, upon learning that disclosure of such Records is required or is sought in or by a
court or governmental body of competent jurisdiction or through other means, give prompt notice to
the Company and allow the
Company, at its expense, to undertake appropriate action to prevent disclosure of, or to
obtain a protective order for, the Records deemed confidential. Nothing herein (or in any other
confidentiality agreement between the Company and any Investor) shall be deemed to limit the
Investor(s)’ ability to sell Registrable Securities in a manner which is otherwise consistent with
applicable laws and regulations.

	 	 	 	 	 	 	 
	 

	 	 	7	 	 	Registration Rights Agreement

 

 

          (h) The Company shall hold in confidence and not make any disclosure of information concerning
an Investor provided to the Company unless (i) disclosure of such information is necessary to
comply with federal or state securities laws or the rules of any securities exchange or trading
market on which the Company Common Stock is listed or traded, (ii) the disclosure of such
information is necessary to avoid or correct a misstatement or omission in any Registration
Statement, or (iii) the release of such information is ordered pursuant to a subpoena or other
final, non-appealable order from a court or governmental body of competent jurisdiction. The
Company agrees that it shall, upon learning that disclosure of such information concerning an
Investor is sought in or by a court or governmental body of competent jurisdiction or through other
means, give prompt written notice to such Investor and allow such Investor, at the Investor’s
expense, to undertake appropriate action to prevent disclosure of, or to obtain a protective order
for, such information.

          (i) The Company shall use commercially reasonable efforts either to (i) cause all the
Registrable Securities covered by a Registration Statement to be listed on each securities exchange
on which securities of the same class or series issued by the Company are then listed, if any, if
the listing of such Registrable Securities is then permitted under the rules of such exchange, or
(ii) secure designation and quotation of all the Registrable Securities covered by a Registration
Statement on the NASDAQ Global Market. The Company shall pay all fees and expenses in connection
with satisfying its obligation under this Section 3(i).

          (j) The Company shall cooperate with the Investor(s) who hold Registrable Securities being
offered and, to the extent applicable, facilitate the timely preparation and delivery of
certificates representing the Registrable Securities to be offered pursuant to a Registration
Statement and enable such certificates to be in such denominations or amounts, as the case may be,
as the Investor(s) may reasonably request and registered in such names as the Investor(s) may
request.

          (k) If requested by an Investor, the Company shall (i) as soon as practicable incorporate in a
prospectus supplement or post-effective amendment such information as an Investor reasonably
requests to be included therein relating to the sale and distribution of Registrable Securities,
including, without limitation, information with respect to the number of Registrable Securities
being offered or sold, the purchase price being paid therefor and any other terms of the offering
of the Registrable Securities to be sold in such offering and (ii) as soon as practicable make all
required filings of such prospectus supplement or post-effective amendment after being notified of
the matters to be incorporated in such prospectus supplement or post-effective amendment.

          (l) Notwithstanding anything to the contrary herein, at any time after the Registration
Statement has been declared effective by the SEC, the Company may delay or suspend the
effectiveness of any Registration Statement or the use of any prospectus forming a part of the
Registration Statement due to the non-disclosure of material, non-public information concerning the
Company the disclosure of which at the time is not, in the good faith opinion of the Company, in
the best interest of the Company (a “Grace Period”); provided, that the Company
shall promptly notify the

	 	 	 	 	 	 	 
	 

	 	 	8	 	 	Registration Rights Agreement

 

 

Investor(s) in writing of the existence of a Grace Period in conformity
with the provisions of this Section 3(l) and the date on which the Grace Period will begin
(such notice, a “Commencement Notice”); and, provided further, that no Grace Period
shall exceed thirty (30) consecutive days, and such Grace Periods shall not exceed an aggregate
total of ninety (90) days during any three hundred sixty five (365) day period. For purposes of
determining the length of a Grace Period above, the Grace Period shall begin on and include the
date specified by the Company in the Commencement Notice and shall end on and include the date the
Investor(s) receive written notice of the termination of the Grace Period by the Company (which
notice may be contained in the Commencement Notice). The provisions of Section 3(e) hereof
shall not be applicable during any Grace Period. Upon expiration of the Grace Period, the Company
shall again be bound by the first sentence of Section 3(e) with respect to the information
giving rise thereto unless such material, non-public information is no longer applicable.
Notwithstanding anything to the contrary, the Company shall cause its transfer agent to deliver
unlegended shares of Company Common Stock to a transferee of an Investor in accordance with the
terms of the Stock and Warrant Purchase Agreement in connection with any sale of Registrable
Securities with respect to which an Investor has entered into a contract for sale, and delivered a
copy of the prospectus included as part of the applicable Registration Statement, prior to the
Investor’s receipt of the notice of a Grace Period and for which the Investor has not yet settled.

     Section 4. Obligations of the Investor(s).

          (a) At least seven (7) Business Days prior to the first anticipated filing date of a
Registration Statement, the Company shall notify each Investor in writing of the information the
Company requires from each such Investor if such Investor elects to have any of such Investor’s
Registrable Securities included in such Registration Statement and provide each such Investor with
a copy of the Company’s then-current selling stockholder questionnaire (a copy of which is attached
as Exhibit A hereto, a “Selling Stockholder Questionnaire”). It shall be a
condition precedent to the obligations of the Company to complete the registration pursuant to this
Agreement with respect to the Registrable Securities of a particular Investor that such Investor
shall furnish to the Company a completed Selling Stockholder Questionnaire, along with such other
information regarding itself, the Registrable Securities held by it and the intended method of
disposition of the Registrable Securities held by it as may reasonably be required to effect the
effectiveness of the registration of such Registrable Securities, and shall execute other such
documents in connection with such registration as the Company may reasonably request.
Notwithstanding anything to the contrary contained herein, the
Company shall not be required to file any such Registration Statement until the third Business
Day after the day on which it receives all Selling Stockholder Questionnaires.

          (b) Each Investor, by such Investor’s acceptance of the Registrable Securities, agrees to
cooperate with the Company as reasonably requested by the Company in connection with the
preparation and filing of any Registration Statement hereunder, unless such Investor has notified
the Company in writing of such Investor’s election to exclude all of such Investor’s Registrable
Securities from such Registration Statement.

	 	 	 	 	 	 	 
	 

	 	 	9	 	 	Registration Rights Agreement

 

 

          (c) Each Investor agrees that, upon receipt of any notice from the Company of the happening of
any event of the kind described in Section 3(f) or the first sentence of
Section 3(e), such Investor will immediately discontinue disposition of Registrable
Securities pursuant to any Registration Statement(s) covering such Registrable Securities until
such Investor’s receipt of the copies of the supplemented or amended prospectus contemplated by the
second sentence of Section 3(e) or receipt of notice that no supplement or amendment is
required.

          (d) Each Investor covenants and agrees that it will comply with any applicable prospectus
delivery requirements of the Securities Act as applicable to it in connection with sales of
Registrable Securities pursuant to a Registration Statement.

     Section 5. Expenses of Registration. All reasonable expenses, other than underwriting
discounts and commissions, incurred in connection with registrations, filings or qualifications
pursuant to Sections 2 and 3 hereof, including, without limitation, all
registration, listing and qualifications fees, printers and accounting fees, and fees and
disbursements of counsel for the Company shall be paid by the Company. All underwriting discounts
and selling commissions applicable to the sale of the Registrable Securities shall be paid by the
Investor(s), provided, however, that the Company shall reimburse the Investor(s) for the reasonable
actual fees and disbursements of one legal counsel designated by the holders of at least a majority
of the Registrable Securities in connection with registration, filing or qualification pursuant to
Sections 2 and 3 of this Agreement, which amount shall be limited to $25,000 in
total over the term of this Agreement.

     Section 6. Indemnification. In the event any Registrable Securities are included in a
Registration Statement under this Agreement:

          (a) To the fullest extent permitted by applicable Law, the Company will, and hereby does,
indemnify and hold harmless each Investor, the directors, officers, partners, members, employees,
agents, representatives of, and each Person, if any, who controls any Investor within the meaning
of the Securities Act or the Exchange Act (each, an “Investor Indemnified Person”), against
any losses, claims, damages, liabilities, judgments, fines, penalties, charges, costs, reasonable
attorneys’
fees, amounts paid in settlement or expenses, joint or several with an aggregate value of at
least $10,000, (as determined by the applicable Indemnified Party acting in good faith),
(collectively, “Claims”), incurred in investigating, preparing or defending any action,
claim, suit, inquiry, proceeding, investigation or appeal taken from the foregoing by or before any
court or governmental, administrative or other regulatory agency, body or the SEC, whether pending
or threatened, whether or not an Indemnified Person is or may be a party thereto (“Indemnified
Damages”), to which any of them may become subject to the extent that such Claims (or actions
or proceedings, whether commenced or threatened, in respect thereof) arise out of or are based
upon: (i) any untrue statement or alleged untrue statement of a material fact in a Registration
Statement or any post-effective amendment thereto or in any filing made in connection with the
qualification of the offering under the securities or other “blue sky” laws of any jurisdiction in
which Registrable Securities are offered (“Blue Sky Filing”), or the omission or alleged

	 	 	 	 	 	 	 
	 

	 	 	10	 	 	Registration Rights Agreement

 

 

omission to state a material fact required to be stated therein or necessary to make the statements
therein not misleading; (ii) any untrue statement or alleged untrue statement of a material fact
contained in any preliminary prospectus if used prior to the Effective Registration Date of such
Registration Statement, or contained in the final prospectus (as amended or supplemented, if the
Company files any amendment thereof or supplement thereto with the SEC) or the omission or alleged
omission to state therein any material fact necessary to make the statements made therein, in the
light of the circumstances under which the statements therein were made, not misleading; (iii) any
violation or alleged violation by the Company of any federal, state or common law, rule or
regulation applicable to the Company in connection with any Registration Statement, prospectus or
any preliminary prospectus, any amendment or supplement thereto, or the issuance of any Registrable
Securities to Holdings; or (iv) any material violation of this Agreement (the matters in the
foregoing clauses (i) through (iv) being, collectively, “Violations”).
Subject to Section 6(c), the Company shall reimburse the Investor Indemnified Persons,
promptly as such expenses are incurred and are due and payable, for any legal fees or other
reasonable expenses incurred by them in connection with investigating or defending any such Claim.
Notwithstanding anything to the contrary contained herein, the indemnification agreement contained
in this Section 6(a): (A) shall not apply to a Claim by an Investor Indemnified Person
arising out of or based upon a Violation that occurs in reliance upon and in conformity with
information furnished in writing to the Company by or on behalf of any Investor Indemnified Person
expressly for use in connection with the preparation of the Registration Statement or any such
amendment thereof or supplement thereto; (B) with respect to any preliminary prospectus, shall not
inure to the benefit of any such Person from whom the Person asserting any such Claim purchased the
Registrable Securities that are the subject thereof (or to the benefit of any Person controlling
such Person) if the untrue statement or omission of material fact contained in the preliminary
prospectus was corrected in the prospectus, as then amended or supplemented, if such prospectus was
timely made available by the Company pursuant to Section 3(d), and the Investor Indemnified
Person was promptly advised in writing not to use the incorrect prospectus prior to the use giving
rise to a violation and such Investor Indemnified Person, notwithstanding such advice, used it or
failed to deliver the correct prospectus as required by the Securities Act and such correct
prospectus was timely made available pursuant to Section 3(d); (C) shall not be available
to the extent such Claim is
based on a failure of the Investor Indemnified Person to deliver or to cause to be delivered
the prospectus made available by the Company, including a corrected prospectus, if such prospectus
or corrected prospectus was timely made available by the Company pursuant to Section 3(d);
and (D) along with the agreement with respect to contribution contained in Section 7, shall
not apply to amounts paid in settlement of any Claim if such settlement is effected without the
prior written consent of the Company, which consent shall not be unreasonably withheld or delayed.
Such indemnity shall remain full force and effect regardless of any investigation made by or on
behalf of the Investor Indemnified Person and shall survive the transfer of the Registrable
Securities by the Investor(s) pursuant to Section 9.

          (b) In connection with any Registration Statement in which an Investor is participating, each
such Investor agrees to severally and not jointly indemnify, and hold harmless, to the same extent
and in the same manner as is set forth in

	 	 	 	 	 	 	 
	 

	 	 	11	 	 	Registration Rights Agreement

 

 

Section 6(a), the Company, each of its directors,
each of its officers who signs the Registration Statement, each Person, if any, who controls the
Company within the meaning of the Securities Act or the Exchange Act, and the Company’s general
counsel to the extent that such counsel delivers one or more legal opinions in conjunction with the
preparation and filing of the Registration Statement (each, a “Company Indemnified
Person”), against any Claim or Indemnified Damages to which any of them may become subject,
under the Securities Act, the Exchange Act or otherwise, insofar as such Claim or Indemnified
Damages arise out of or are based upon any Violation, in each case to the extent, and only to the
extent, that such Violation occurs in reliance upon and in conformity with written information
furnished to the Company by such Investor expressly for use in connection with such Registration
Statement; and, subject to Section 6(d), such Investor will reimburse, promptly as such
expenses are incurred and are due and payable, any legal or other expenses reasonably incurred by a
Company Indemnified Person in connection with investigating or defending any such Claim;
provided, however, that the indemnity agreement contained in this
Section 6(b) and the agreement with respect to contribution contained in Section 7
shall not apply to amounts paid in settlement of any Claim if such settlement is effected without
the prior written consent of such Investor, which consent shall not be unreasonably withheld or
delayed; provided, further, however, that an Investor shall be liable under this
Section 6(b) for only that amount of a Claim or Indemnified Damages as does not exceed the
net proceeds to such Investor as a result of the sale of Registrable Securities pursuant to such
Registration Statement. Such indemnity shall remain in full force and effect regardless of any
investigation made by or on behalf of such Company Indemnified Person and shall survive the
transfer of the Registrable Securities by the Investor(s) pursuant to Section 9.
Notwithstanding anything to the contrary contained herein, the indemnification agreement contained
in this Section 6(b) with respect to any preliminary prospectus shall not inure to the
benefit of any Company Indemnified Person if the untrue statement or omission of material fact
contained in the preliminary prospectus was corrected on a timely basis in the prospectus, as then
amended or supplemented.

          (c) If either an Investor Indemnified Person or a Company Indemnified Person (an
“Indemnified Person”) proposes to assert a right to be indemnified under this
Section 6, such Indemnified Person shall notify either the
Company or the relevant Investor(s), as applicable (the “Indemnifying Person”),
promptly after receipt of notice of commencement of any action, suit or proceeding against such
Indemnified Person (an “Indemnified Proceeding”) in respect of which a Claim is to be made
under this Section 6, or the incurrence or realization of any Indemnified Damages in
respect of which a Claim is to be made under this Section 6, of the commencement of such
Indemnified Proceeding or of such incurrence or realization, enclosing a copy of all relevant
documents, including all papers served and claims made, but the omission to so notify the
applicable Indemnifying Person promptly of any such Indemnified Proceeding or incurrence or
realization shall not relieve (x) such Indemnifying Person from any liability that it may have to
such Indemnified Person under this Section 6 or otherwise, except, as to such Indemnifying
Person’s liability under this Section 6, to the extent, but only to the extent, that such
Indemnifying Person shall have been prejudiced by such omission, or (y) any other Indemnifying
Person from liability that it may have to any Indemnified Person under the Operative Documents.

	 	 	 	 	 	 	 
	 

	 	 	12	 	 	Registration Rights Agreement

 

 

          (d) In case any Indemnified Proceeding shall be brought against any Indemnified Person and it
shall notify the applicable Indemnifying Person of the commencement thereof as provided by
Section 6(c) and such Indemnifying Person shall be entitled to participate in, and provided
such Indemnified Proceeding involves a claim solely for money damages and does not seek an
injunction or other equitable relief against the Indemnified Person and is not a criminal or
regulatory action, to assume the defense of, such Indemnified Proceeding with counsel reasonably
satisfactory to such Indemnified Person, and after notice from such Indemnifying Person to such
Indemnified Person of such Indemnifying Person’s election so to assume the defense thereof and the
failure by such Indemnified Person to object to such counsel within ten (10) Business Days
following its receipt of such notice, such Indemnifying Person shall not be liable to such
Indemnified Person for legal or other expenses related to such Indemnified Proceedings incurred
after such notice of election to assume such defense except as provided below and except for the
reasonable costs of investigating, monitoring or cooperating in such defense subsequently incurred
by such Indemnified Person reasonably necessary in connection with the defense thereof. Such
Indemnified Person shall have the right to employ its counsel in any such Indemnified Proceeding,
but the reasonable fees and expenses of such counsel shall be at the expense of such Indemnified
Person unless:

               (i) the employment of counsel by such Indemnified Person at the expense of the applicable
Indemnifying Person has been authorized in writing by such Indemnifying Person;

               (ii) such Indemnified Person shall have reasonably concluded in its good faith (which
conclusion shall be determinative unless a court determines that such conclusion was not reached
reasonably and in good faith) that there is or may be a conflict of interest between the applicable
Indemnifying Person and such Indemnified Person in the conduct of the defense of such Indemnified
Proceeding or that there are or may be one or more different or additional defenses, claims,
counterclaims, or causes of action available to such Indemnified Person (it being agreed that in
any case
referred to in this clause (ii) such Indemnifying Person shall not have the right to
direct the defense of such Indemnified Proceeding on behalf of the Indemnified Person);

               (iii) the applicable Indemnifying Person shall not have employed counsel reasonably acceptable
to the Indemnified Person, to assume the defense of such Indemnified Proceeding within a reasonable
time after notice of the commencement thereof; provided, however, that (A) this
clause (iii) shall not be deemed to constitute a waiver of any conflict of interest that
may arise with respect to any such counsel, and (B) an Indemnified Person may not invoke this
clause (iii) if such Indemnified Person failed to timely object to such counsel pursuant to
the first paragraph of this Section 6(d) above (it being agreed that in any case referred
to in this clause (iii) such Indemnifying Party shall not have the right to direct the
defense of such Indemnified Proceeding on behalf of the Indemnified Party); or

               (iv) any counsel employed by the applicable Indemnifying Person shall fail to timely commence
or reasonably conduct the defense of

	 	 	 	 	 	 	 
	 

	 	 	13	 	 	Registration Rights Agreement

 

 

such Indemnified Proceeding, and such failure has prejudiced
(or is in immediate danger of prejudicing) the outcome of such Indemnified Proceeding (it being
agreed that in any case referred to in this clause (iv) such Indemnifying Party shall not
have the right to direct the defense of such Indemnified Proceeding on behalf of the Indemnified
Party);

in each of which cases the reasonable fees and expenses of counsel for such Indemnified Person
shall be at the expense of such Indemnifying Person. The Indemnifying Person shall be responsible
for the reasonable fees and expenses of only one counsel retained by all Indemnified Persons with
respect to any Indemnified Proceeding, and any additional counsel shall be retained at the expense
of such Indemnified Person, unless counsel for any Indemnified Person reasonably concludes in good
faith (which conclusion shall be determinative unless a court determines that such conclusion was
not reached reasonably and in good faith) that there is or may be a conflict of interest between
such Indemnified Person and one or more other Indemnified Persons in the conduct of the defense of
such Indemnified, in which case the Indemnifying Person shall be responsible for the reasonable
fees and expenses of such additional counsel.

          (e) Without the prior written consent of such Indemnified Person, such Indemnifying Person
shall not settle or compromise, or consent to the entry of any judgment in, any pending or
threatened Indemnified Proceeding, unless such settlement, compromise, consent or related judgment
(i) includes an unconditional release of such Indemnified Person from all liability for Losses
arising out of such claim, action, investigation, suit or other legal proceeding, (ii) provides for
the payment of money damages as the sole relief for the claimant (whether at law or in equity),
(iii) involves no admission of fact adverse to such Indemnified Person or finding or admission of
any violation of law or the rights of any Person by the Indemnified Person, and (iv) is not in the
nature of a criminal or regulatory action. No Indemnified Person shall or compromise, or consent
to the entry of any judgment in, any pending or threatened Indemnified Proceeding (A) in respect of
which any payment would result hereunder or under any other Operative Document, (B) which includes
an injunction that will adversely affect any Indemnifying Person, (C) which involves an admission
of fact
adverse to any Indemnifying Person or finding or admission of any violation of law or the
rights of any Person by the Indemnifying Person, or (D) which is in the nature of a criminal or
regulatory action, without the prior written consent of the Indemnifying Person, such consent not
to be unreasonably conditioned, withheld or delayed.

          (f) The indemnification required by this Section 6 shall be made by periodic payments
of the amount of Claims during the course of the investigation or defense, as and when Indemnified
Damages are incurred.

     Section 7. Contribution. To the extent any indemnification by an Indemnifying Person
is prohibited or limited by law, such Indemnifying Person agrees to make the maximum contribution
with respect to any amounts for which it would otherwise be liable under Section 6 to the
fullest extent permitted by law; provided, however, that: (i) no Person involved in
the sale of Registrable Securities which Person is guilty of fraudulent misrepresentation (within
the meaning Section 11(f) of the Securities Act) in connection with such sale shall be entitled to
contribution from any Person

	 	 	 	 	 	 	 
	 

	 	 	14	 	 	Registration Rights Agreement

 

 

involved in such sale of Registrable Securities who was not guilty of
fraudulent misrepresentation; and (ii) contribution by any seller of Registrable Securities shall
be limited in amount to the net amount of proceeds received by such seller from the sale of such
Registrable Securities pursuant to such Registration Statement.

     Section 8. Reports Under The Exchange Act. With a view to making available to the
Investor(s) the benefits of Rule 144 promulgated under the Securities Act or any other similar rule
or regulation of the SEC that may at any time permit the Investor(s) to sell securities of the
Company to the public without registration (“Rule 144”), the Company agrees to use
commercially reasonable efforts to:

          (a) make and keep public information available, as those terms are understood and defined in
Rule 144;

          (b) file with the SEC in a timely manner all reports and other documents required of the
Company under the Securities Act and the Exchange Act so long as the Company remains subject to
such requirements and the filing of such reports and other documents is required for the applicable
provisions of Rule 144; and

          (c) furnish to each Investor so long as such Investor owns Registrable Securities, promptly
upon request, (i) a written statement by the Company, if true, that it has complied with the
reporting requirements of Rule 144, the Securities Act and the Exchange Act, (ii) a copy of the
most recent annual or quarterly report of the Company and such other reports and documents so filed
by the Company, and (iii) such other information as may be reasonably requested to permit the
Investor(s) to sell such securities pursuant to Rule 144 without registration.

     Section 9. Assignment of Registration Rights. The rights under this Agreement with
respect to the Share Purchase Related Registrable Securities shall be automatically assignable in
full or in part by the Investor(s) to any transferee of all or at least 30,000 of such Investor’s
Share Purchase Related Registrable Securities (or, if an Investor then holds 30,000 shares, a
transfer of all such Investor’s Share Purchase Related Registrable Securities), if: (i) the
Investor agrees in writing with the transferee or assignee to assign such rights, and a copy of
such agreement is furnished to the Company within a reasonable time after such assignment; (ii) the
Company is, within a reasonable time after such transfer or assignment, furnished with written
notice of (A) the name and address of such transferee or assignee, and (B) the securities with
respect to which such registration rights are being transferred or assigned; (iii) immediately
following such transfer or assignment the further disposition of such securities by the transferee
or assignee is restricted under the Securities Act and applicable state securities laws; (iv) at or
before the time the Company receives the written notice contemplated by clause (ii) of this
sentence the transferee or assignee agrees in writing with the Company to be bound by all of the
provisions contained herein, including the obligation to provide the Company with a completed
Selling Stockholder Questionnaire, as applicable; and (v) such transfer shall have been made in
accordance with the applicable transfer requirements set forth in Article VI of the Stock
and Warrant Purchase Agreement.

	 	 	 	 	 	 	 
	 

	 	 	15	 	 	Registration Rights Agreement

 

 

     Section 10. Amendment.

          (a) The terms of this Agreement shall not be altered, modified, amended, waived or
supplemented in any manner whatsoever except by a written instrument signed by each of (i) the
Company and (ii) Investor(s) holding a majority of the Registrable Securities (other than in the
case of any alteration, modification, amendment, waiver or supplement which affects any individual
Investor in a manner that is less favorable or more detrimental to such Investor than to the other
Investor(s) solely based on the face of such alteration, modification, amendment, waiver or
supplement and without regard to the number of Registrable Securities held by such Investor, in
which case, such alteration, modification, amendment, waiver or supplement must also be approved by
such less favorably or more detrimentally treated Investor).

          (b) Notwithstanding Section 10(a), any party hereto may waive, solely with respect to
itself, any one or more of its rights hereunder without the consent of any other party hereto;
provided that no such waiver shall be effective unless set forth in a written instrument
executed by the party against whom such waiver is to be effective.

     Section 11. Miscellaneous.

          (a) A Person is deemed to be a holder of Registrable Securities whenever such Person owns or
is deemed to own of record such Registrable Securities. If the Company receives conflicting
instructions, notices or elections from two or more Persons with respect to the same Registrable
Securities, the Company shall act upon the basis of instructions, notice or election received from
the such record owner of such Registrable Securities.

          (b) Any notice, request, demand, waiver, consent, approval or other communication which is
required or permitted to be given to any Party shall be in writing addressed to the Party at its
address set forth below and shall be deemed given (i) when delivered to the Party personally, (ii)
if sent to the Party by facsimile transmission (promptly followed by a hard-copy delivered in
accordance with this Section 11(b)), when the transmitting Party obtains written proof of
transmission and receipt; provided, however, that notwithstanding the foregoing, any communication
sent by facsimile transmission after 5:00 PM (receiving Party’s time) or not on a Business Day
shall not be deemed received until the next Business Day, (iii) when delivered by next Business Day
delivery by a nationally recognized courier service, or (iv) if sent by registered or certified
mail, when received, provided postage and registration or certification fees are prepaid and
delivery is confirmed by return receipt:

If to the Company:

OXiGENE, Inc.

230 Third Avenue

Waltham, MA 02451

	 	 	 	 	 	 	 
	 

	 	 	16	 	 	Registration Rights Agreement

 

 

Attn: Chief Executive Officer

Fax: (781) 547-6800

If to Holdings:

Symphony ViDA Holdings LLC

7361 Calhoun Place, Suite 325

Rockville, MD 20855

Attn: Robert L. Smith, Jr.

Fax: (301) 762-6154

with a copy to:

Symphony Capital Partners, L.P.

875 Third Avenue, 18th Floor

New York, NY 10022

Attn: Mark Kessel

Fax: (212) 632-5401

and

Symphony Strategic Partners, LLC

875 Third Avenue, 18th Floor

New York, NY 10022

Attn: Mark Kessel

Fax: (212) 632-5401

or to such other address as such party may from time to time specify by notice given in the manner
provided herein to each other party entitled to receive notice hereunder.

          (c) This Agreement shall be governed by, and construed in accordance with, the laws of the
State of New York; except to the extent that this Agreement pertains to the internal
governance of Holdings or the Company and to such extent this Agreement shall be governed and
construed in accordance with the laws of the State of Delaware.

          (d) Each of the parties hereto hereby irrevocably and unconditionally submits, for itself and
its property, to the nonexclusive jurisdiction of any New York State court, any Delaware State
court or federal court of the United States of America sitting in New York County in the State of
New York or Wilmington, Delaware, and any appellate court from any jurisdiction thereof, in any
action or proceeding arising out of or relating to this Agreement, or for recognition or
enforcement of any judgment, and each of the parties hereto hereby irrevocably and unconditionally
agrees that all claims in respect of any such action or proceeding may be heard and determined in
any such New York State court, any such Delaware State court or, to the fullest extent permitted by
law, in such federal court. Each of the parties hereto agrees that a final judgment in any such
action or proceeding shall be conclusive and may be enforced in

	 	 	 	 	 	 	 
	 

	 	 	17	 	 	Registration Rights Agreement

 

 

other jurisdictions by suit on the
judgment or in any other manner provided by law. Nothing in this Agreement shall affect any right
that any party hereto may otherwise have to bring any action or proceeding relating to this
Agreement.

          (e) Each of the parties hereto irrevocably and unconditionally waives, to the fullest extent
it may legally and effectively do so, any objection that it may now or hereafter have to the laying
of venue of any suit, action or proceeding arising out of or relating to this Agreement in any New
York State or federal court, or any Delaware State or Federal court. Each of the parties hereto
hereby irrevocably waives, to the fullest extent permitted by law, the defense of an inconvenient
forum to the maintenance of such action or proceeding in any such court. Each of the parties
hereby consent to service of process by mail.

          (f) WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO IRREVOCABLY WAIVES ALL RIGHT TO
TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM (WHETHER BASED ON CONTRACT, TORT OR
OTHERWISE) ARISING OUT OF OR RELATING TO THIS AGREEMENT.

          (g) Entire Agreement. This Agreement (including any Annexes, Schedules, Exhibits or
other attachments hereto) constitutes the entire agreement between the parties hereto with respect
to the matters covered hereby and supersedes all prior and contemporaneous agreements,
correspondence, discussion and understandings with respect to such matters between the parties
hereto, excluding the Operative Documents.

          (h) Successors; Assignment; Counterparts.

               (i) Nothing expressed or implied herein is intended or shall be construed to confer upon or to
give to any Person, other than the parties hereto, any right, remedy or claim under or by reason of
this Agreement or of any term, covenant or condition hereof, and all the terms, covenants,
conditions, promises and agreements contained herein shall be for the sole and exclusive benefit of
the parties hereto and their successors and permitted assigns provided, however,
that, subject to the requirements of Section 9, this Agreement shall inure to the benefit
of and be binding upon the permitted successors and assigns of each of the parties hereto.

               (ii) This Agreement may be executed in one or more counterparts, each of which, when executed,
shall be deemed an original but all of which taken together shall constitute one and the same
Agreement.

          (i) Each party shall do and perform, or cause to be done and performed, all such further acts
and things, and shall execute and deliver all such other agreements, certificates, instruments and
documents, as any other party may reasonably request in order to carry out the intent and
accomplish the purposes of this Agreement and the consummation of the transactions contemplated
hereby.

	 	 	 	 	 	 	 
	 

	 	 	18	 	 	Registration Rights Agreement

 

 

          (j) All consents and other determinations required to be made by the Investor(s) pursuant to
this Agreement shall be made, unless otherwise specified in this Agreement, by Investor(s) holding
at least a majority of the Registrable Securities.

[SIGNATURES FOLLOW ON NEXT PAGE]

	 	 	 	 	 	 	 
	 

	 	 	19	 	 	Registration Rights Agreement

 

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by their
respective officers or other representatives thereunto duly authorized, as of the date first above
written.

	 	 	 	 	 	 	 
	 	 	OXiGENE, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ John A. Kollins	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	John A. Kollins	 	 
	 

	 	Title:
	 	Chief Operating Officer	 	 
	 
	 	 	 	 	 	 
	 	 	SYMPHONY ViDA HOLDINGS LLC	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Symphony Capital Partners, L.P.,	 	 
	 

	 	 	 	its Manager	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Symphony Capital GP, L.P.,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	Symphony GP, LLC,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Mark Kessel	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:
	 	Mark Kessel	 	 
	 

	 	Title:
	 	Managing Member	 	 

[Signature Page to Registration Rights Agreement]

 

 

EXHIBIT A

FORM OF SELLING STOCKHOLDER QUESTIONNAIRE

NOTICE

               The undersigned beneficial owner (the “Selling Securityholder”) of Registrable
Securities hereby gives notice to OXiGENE, Inc. (the “Company”) of its intention to sell
or otherwise dispose of Registrable Securities beneficially owned by it and listed below in
Item 3 (unless otherwise specified under such Item 3) pursuant to the Registration
Statement, pursuant to the terms of the Registration Rights Agreement (the “Registration Rights
Agreement”) dated as of October 1, 2008, by and between the Company and Symphony ViDA Holdings
LLC (“Holdings”). Capitalized terms used but not defined herein are used as defined in
Registration Rights Agreement.

               The undersigned hereby gives notice to the Company of its intention to sell the Registrable
Securities listed in Item 3 below, pursuant to the Registration Statement and, provides the
following information to the Company and represents and warrants that such information is accurate
and complete:

QUESTIONNAIRE

	1.	 	Full legal name of Selling Securityholder:                                         

	 	(a)	 	Full legal name of registered holder of the Registrable Securities (if not
the same as (1) above) through which Registrable Securities listed in Item
3 below are held:                                         
	 
	 	(b)	 	Full legal name of DTC participant (if applicable and if not the same as
(1) above) through which Registrable Securities listed in Item 3 below
are held:                                         
	 
	 	(c)	 	Status (yes/no) of Selling Securityholder as a registered broker-dealer or an
affiliate of a registered broker-dealer (please describe to the extent applicable):
                                        

	2.	 	Address for notices to Selling Securityholder:                                         

	 	 	Telephone:                                         
	 
	 	 	Fax:                                         
	 
	 	 	Contact Person:                                         

	3.	 	Beneficial Ownership of Registrable Securities:

	 	(a)	 	Type and number of Registrable Securities beneficially owned:
                                        
	 
	 	(b)	 	CUSIP No(s). of such Registrable Securities beneficially owned:

Exhibit A to the

Registration Rights Agreement

 

 

	4.	 	Beneficial ownership of other securities of the Company owned by the Selling Securityholder.

          Except as set forth below in this Item 4, the undersigned is not the beneficial or
registered owner of any securities of the Company other than the Registrable Securities listed
above in Item 3.

	 	(a)	 	Type and amount of other securities beneficially owned by the Selling
Securityholder:
	 
	 	(b)	 	CUSIP No(s). of such other securities beneficially owned:

	5.	 	Relationships with the Company:

          Except as set forth below, neither the undersigned nor any of its affiliates, officers,
directors or principal equity holders (owners of 5% or more of the equity securities of the
undersigned) has held any position or office or has had any other material relationship with the
Company (or its predecessors or affiliates) during the past three years.

State any exceptions here:

      

      

	6.	 	Plan of Distribution:

          Except as set forth below, the undersigned (including its donees, distributees or pledgees)
intends to distribute the Registrable Securities listed above in Item 3 pursuant to the
Registration Statement only as follows (if at all). Such Registrable Securities may be sold from
time to time directly by the undersigned or, alternatively, through underwriters, broker-dealers or
agents. If the Registrable Securities are sold through underwriters, broker-dealers or agents, the
Selling Securityholder will be responsible for any related underwriting discounts or commissions or
agents’ commissions. Such Registrable Securities may be sold in one or more transactions at fixed
prices, at prevailing market prices at the time of sale, at varying prices determined at the time
of sale or at negotiated prices. The selling stockholders may sell their shares by one or more of
or a combination of the following methods: (i) purchases by a broker-dealer as principal and resale
by such broker-dealer for its own account pursuant to this prospectus; (ii) ordinary brokerage
transactions and transactions in which the broker solicits purchasers; (iii) block trades in which
the broker-dealer so engaged will attempt to sell the shares as agent but may position and resell a
portion of the block as principal to facilitate the transaction; (iv) an over-the-counter
distribution in accordance with the rules of the Nasdaq Global Market; (v) in privately negotiated
transactions; and (vi) in options transactions. The undersigned may also sell Registrable
Securities short and

	 	 	 	 	 	 	 
	 

	 	 	 	 	 	Exhibit A to the
	 

	 	 	2	 	 	Registration Rights Agreement

 

 

deliver Registrable Securities to close out short positions, or loan or pledge Registrable
Securities to broker-dealers that in turn may sell such securities.

State any exceptions here:

      

      

     Note: In no event will such method(s) of distribution take the form of an underwritten
offering of the Registrable Securities without the prior agreement of the Company.

     The undersigned acknowledges its obligation to comply with the provisions of the Exchange Act
and the rules thereunder relating to stock manipulation, particularly Regulation M thereunder (or
any successor rules or regulations), in connection with any offering of Registrable Securities
pursuant to the Registration Rights Agreement. The undersigned agrees that neither it nor any
person acting on its behalf will engage in any transaction in violation of such provisions.

     In the event that the Selling Securityholder transfers all or a portion of the Registrable
Securities listed in Item 3 above after the date on which such information is provided to
the Company, the Selling Securityholder agrees to notify the transferee(s) at the time of the
transfer of its rights and obligations under this Questionnaire and the Registration Rights
Agreement.

     The Selling Securityholder hereby acknowledges its obligations under the Registration Rights
Agreement to indemnify and hold harmless certain persons as set forth therein.

     Pursuant to the Registration Rights Agreement, the Company has agreed under certain
circumstances to indemnify the Selling Securityholder against certain liabilities.

     In accordance with the undersigned’s obligation under the Registration Rights Agreement to
provide such information as may be required by law for inclusion in the Registration Statement, the
undersigned agrees to promptly notify the Company of any inaccuracies or changes in the information
provided herein that may occur subsequent to the date hereof at any time while the Registration
Statement remains effective, including, without limitation, any change in the undersigned’s
beneficial ownership of Registrable Securities.

     All notices hereunder and pursuant to the Registration Rights Agreement shall be made in
writing to the Selling Securityholder at the address set forth in Section 2 above, and to
the Company at the address set forth below.

     By signing below, the undersigned consents to the disclosure of the information contained
herein in its answers to Items 1 through 6 above and the inclusion of such

	 	 	 	 	 	 	 
	 

	 	 	 	 	 	Exhibit A to the
	 

	 	 	3	 	 	Registration Rights Agreement

 

 

information in the Registration Statement and the related prospectus. The undersigned
understands that such information will be relied upon by the Company in connection with the
preparation or amendment of the Registration Statement and the related prospectus.

     Once this Questionnaire is executed by the Selling Securityholder and delivered to the
Company, the terms of this Questionnaire, and the representations and warranties contained herein,
shall be binding on, shall inure to the benefit of and shall be enforceable by the respective
successors, heirs, personal representatives and assigns of the Company and the Selling
Securityholder (with respect to the Registrable Securities beneficially owned by such Selling
Securityholder and listed in Item 3 above). This Agreement shall be governed in all
respects by the laws of the State of New York.

     IN WITNESS WHEREOF the undersigned, by authority duly given, has caused this Questionnaire to
be executed and delivered either in person or by its duly authorized agent.

	 	 	 	 	 	 	 	 	 	 
	Dated:  	 	 	Beneficial Owner:	 	 	 
	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 
	 

	 	 	By:
	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 

	 	 	Name:	 	 	 	 	 	 
	 	 	 	 	 	 	 	 
	 

	 	 	Title:	 	 	 	 	 	 
	 	 	 	 	 	 	 	 

PLEASE RETURN THE COMPLETED AND EXECUTED QUESTIONNAIRE TO OXIGENE, INC. AT:

230 Third Avenue

Waltham, MA 02451

Attn: Chief Financial Officer

Facsimile: (781) 547-6800

	 	 	 	 	 	 	 
	 

	 	 	 	 	 	Exhibit A to the
	 

	 	 	4	 	 	Registration Rights Agreement

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