Document:

EXHIBIT 10.21

                            SOCIETY IN PARTICIPATION

The undersigned:

o        GENOPOIETIC, simplified joint-stock company with a capital of (euro)
         1,448,265.66, whose registered office is at BEYNOST (01708), 1390, rue
         centrale, and whose identification number is 393 796 305 RCS BOURG EN
         BRESSE, represented by Mr. Andres CRESPO, acting in his capacity as
         president of the company and specially authorised for the purposes of
         the presents by virtue of the by-laws of the company,

o        OPISODIA, a "societe par actions simplifiee" governed by French law,
         with a share capital of (euro) 1,308,000, whose registered head office
         is 6, chemin de l'Industrie, 69570 DARDILLY, and whose identification
         number is 444 637 649 RCS LYON, represented by Mr. Gilles ALBERICI,
         acting in his capacity as president and specially authorised for the
         purposes of the presents by virtue of an opinion of the monitoring
         committee of Opi Group dated December 10, 2003.

HAVE FIRST SET OUT THE FOLLOWING:

         1.       The activity of the company GENOPOIETIC is in particular the
                  manufacture and testing of autologous cancer vaccines, in the
                  context of the carrying out of clinical trials and their
                  commercialisation. The number of vaccines manufactured is
                  estimated at some 150 over a twelve-month period.

                  It also manufactures and tests autologous chondrocytes
                  intended for the carrying out of clinical studies in the
                  context of treatments for gonarthosis. Ten treatments are to
                  be manufactured in this context.

                  It is responsible for the logistics necessary for the
                  transport of biopsies and vaccines.

                  It has, on its BEYNOST site all the equipments, fittings,
                  human resources, know-how, procedures required to manufacture
                  in particular the injectable products and the biological
                  products in accordance with its status of pharmaceutical firm.
                  The GENOPOIETIC's know how more precisely consists in the
                  manufacturing and quality control of gene and cell therapy
                  products, monoclonal antibodies at small or wide scale,
                  recombinant proteins produced in mammalian cell expression
                  systems. All the staff having executive tasks in the different
                  fields of business have a confirmed experience. In its field
                  of activity, GENOPOIETIC is recognized as a European leader.

                  In appendix 9 hereto is attached the approval given to
                  GENOPOIETIC to operate a pharmaceutical firm.

         2.       For its part, the company OPISODIA manufactures and tests
                  monoclonal antibodies (LEUCOTAC), in the context of the
                  carrying out of clinical trials and their commercialisation.
                  The number of batches manufactured is estimated at two over a
                  twelve-month period.

                  It has, on its BESANCON site a 400 m(2) production platform
                  classed GMP including fermentation and purification zones (3
                  bioreactors on the site), a production team, a know-how to
                  product purified solutions of monoclonal antibody (from 1 to
                  100g), following well-known procedures. OPISODIA's know how
                  consists more precisely in cell culture process, proteins
                  purification and viral inactivation. With facilities well
                  fitted to specific scales, this platform has a European wide
                  industrial interest in the biotechnological market for
                  products from the fermentation process.

        3.        The companies GENOPOIETIC and OPISODIA have decided that it is
                  in their interest to combine all their skills, to specialise
                  the BEYNOST and BESANCON sites and to reduce their own
                  manufacturing, testing and administrative costs, giving
                  priority to the development of their own products, but with a
                  will to put in action an ambitious campaign to conclude
                  subcontracts on behalf of third parties subject to their own
                  needs being met.

ON THIS BASIS, THE PARTIES HAVE AGREED, AS FOLLOWS, THE MEMORANDUM AND ARTICLES
OF ASSOCIATION OF A JOINT VENTURE WHICH THEY HAVE DECIDED TO FORM BETWEEN
THEMSELVES:

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                    A R T I C L E S   O F   A S S O C I A T I O N

ARTICLE 1 - FORM OF THE COMPANY

         Between the company GENOPOIETIC and the company OPISODIA, a joint
venture of a commercial nature is formed, governed by articles 1871 to 1872-2 of
the Civil Code and by the present articles of association.

         By express agreement, this company is and shall remain secret and
non-existent with regard to third parties

         In accordance with article 1872-1 of the Civil Code, each partner shall
enter into contracts in his personal name and shall alone be committed with
regard to third parties.

         The present company has no legal personality, registered office or
company purpose and is referred to within the present document as "OGP".

         For all the company's operations, correspondence between the parties
and the common documents and accounts shall be held centrally at GENOPOIETIC's
registered office, at BEYNOST (01708), 1390, rue centrale, where the parties
elect domicile for their joint relationship.

ARTICLE 2 - PURPOSE OF THE COMPANY

         The company purpose comprises all manufacturing and quality control
activities for stable biological products and cell or gene therapy products, in
the context of and in compliance with i) a pharmaceutical plant and with ii) the
good manufacturing practices and good laboratory practices, in accordance with
the regulations in force and under the responsibility of the pharmacist
responsible for GENOPOIETIC's Pharmaceutical Plant.

         The company will carry out its pharmaceutical operations above
mentioned thanks to the prior Approval of Opening of a Pharmaceutical firm
delivered to GENOPOIETIC by the French agency of Sanitary security of products
of health (AFSSaPS) whose minute is enclosed in rider 9 hereinafter.

         In this context, it is in particular responsible for the production of
the part of the regulatory files regarding the testing of raw materials,
supplier audits, manufacturing processes and in-process testing, the
formulation, the packaging and the pre-release testing of the finished products.

         It is also responsible for the activities of process and quality
control test validation on the basis of the procedures and protocols set, as
applicable, by GENOPOIETIC or by OPISODIA.

         Each party undertakes to give to the joint venture, unless exempted in
advance and in writing by the other party, exclusive rights for any
manufacturing or testing activity coming within the purpose of the present
company.

ARTICLE 3 - DURATION OF THE COMPANY

         3-1. The joint venture is concluded for a period of twenty three months
which will start on February 1st, 2004 and end on December 31st, 2005, unless it
is dissolved prematurely as provided in article 17.

         It shall be renewed automatically, from year to year, unless one of the
two parties has notified the other of its wish to terminate it on 31 December
2005 or at the end of each renewal period and this shall be by registered post
with acknowledgement of receipt sent to the other party at least three months
before the end of the initial period or each renewal period.

         Whatever may be the cause of dissolution, if one or more manufacturing
contract are in progress, such dissolution shall only take place when the said
contracts are achieved.

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         3-2. The two partners shall get together on July 1st, 2005 to survey
together and in good faith, the opportunity to incorporate a joint subsidiary
having its own identity.

ARTICLE 4 - CONTRIBUTIONS

         4-1.  CONTRIBUTIONS BY GENOPOIETIC

         GENOPOIETIC shall provide to the joint venture OGP:

         o        the equipment and furniture allocated to its activity of
                  manufacturing and testing especially the one for autologous
                  cancer vaccines and autologous chondrocytes, and comprising
                  the items stated in appendix 1 being pointed out that the
                  joint venture will bear the maintenance obligation of such
                  equipment and furniture,

         o        the know-how pertaining to this activity, namelythe
                  documentation and the operating procedures as well as the
                  necessary skills to manufacture in particular the injectable
                  medicines and biological products in accordance with its
                  status of pharmaceutical firm. The GENOPOIETIC's know how more
                  precisely consists in the manufacturing and quality testing of
                  gene and cellular therapy products, monoclone antibody at
                  small or wide scale and recombining proteins produced in
                  eucariot expressing systems.

         o        a cash sum of(euro)30,201 (i.e. 21,43% of the whole cash
                  contribution)

         4-2.  CONTRIBUTIONS BY OPISODIA

         OPISODIA shall provide to the joint venture OGP:

         o        the equipment and furniture allocated to its activity of
                  manufacturing and testing especially the one for monoclone
                  antibodies, and comprising the items stated in appendix 2
                  being pointed out that the joint venture will bear the
                  maintenance obligation of such equipment and furniture,

         o        the know-how pertaining to this activity, namelythe
                  documentation and the operating procedures as well as the
                  necessary skills to manufacture condensed and purified
                  solutions of monoclone antibody, following the GMP procedures
                  and CPMP guidelines. OPISODIA's know how consists more
                  precisely in the cell culture in cytoculter with a capacity
                  from 15 to 35L, the implementation of purification processes
                  upon chromatographic stands of hydrophobic type,

         o        a cash sum of (euro)110,736 (i.e. 78,57% of the whole cash
                  contribution).

ARTICLE 5 - CONDITIONS REGARDING THE CONTRIBUTIONS

         5-1. REGARDING THE CONTRIBUTIONS BY GENOPOIETIC

         GENOPOIETIC shall be responsible for the costs and obligations
associated with the ownership of the equipment and the furniture whose use it
contributes, i.e. their depreciation and the obligation to replace them once
they have reached the limit of their normal wear and tear.

         5-2. REGARDING THE CONTRIBUTIONS BY OPISODIA

         Likewise, OPISODIA shall be responsible for the costs and obligations
associated with the ownership of the equipment and the furniture whose use it
contributes, i.e. their depreciation and the obligation to replace them once
they have reached the limit of their normal wear and tear.

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         5-3.  COMMON CONDITIONS

         The joint venture shall enjoy, with due commercial care and attention,
the property and rights made available to it from 1 January 2004.

         It shall, from this date, be responsible for all costs associated with
the use of this property and these rights, other than those specified in
paragraphs 5-1 and 5-2 above, particularly the maintenance obligation.

         It shall bear all the risks and all the responsibilities inherent in
the use of the property and rights provided to it. The risks inherent in their
ownership remain the personal matter of each party.

         Each party shall guarantee the enjoyment of the property and rights
belonging to it only subject to the reservation of acts of God or fortuitous
incidents. In the event of any hindrance to maintaining such enjoyment following
an act of God or a fortuitous incident, each party shall not be liable for the
loss of such enjoyment whatever its duration and shall only be obliged to allow
the joint venture to have either any compensation it may receive, as and when it
receives it, or property arising from the use of this compensation if it decides
to use the compensation to obtain replacement property or if the joint venture
so demands once this replacement is possible.

         Notwithstanding the items provided for joint use specified in article
4, no joint indivisible estate shall be formed between the parties. Each of them
shall maintain personal ownership of the items it makes available to the joint
venture, but it may not dispose of them, in whole or in part, nor mortgage,
pledge or provide them as collateral, nor contribute them to a company (other
than in the case of a merger), nor take back into its own use the items it
provides to the joint venture without the authorisation of the other party.

         Acquisitions of new facilities, equipment and furniture which,
independently of those provided by either of the parties in performance of its
replacement obligation, should be acknowledged as necessary for the functioning
of the joint venture, shall be decided by common agreement if their unit value
is in excess of (euro) 1,000 and shall be made by one or other of the parties as
they agree but in any event indivisibly.

ARTICLE 6 - JOINT PREMISES

         As a strictly ancillary matter to the present articles of the joint
venture and without this in any way forming a right to the profit of the other
party with regard to the landlord, the two party companies provide the following
for the use of the joint company:

         o        GENOPOIETIC, premises for manufacturing, control, storage and
                  administrative tasks, located at BEYNOST (01708), 1390 rue
                  Centrale, outlined in rider n(degree)3 of the commercial lease
                  attached (appendix 5), and forming part of the premises let to
                  the latter in accordance with the lease concluded with
                  Etablissement Francais du Sang Rhone-Alpes on 11 August 2000.

         o        OPISODIA, premises for manufacturing, control, technical and
                  administrative tasks located at BESANCON (25000), 1 Bdv
                  Fleming, limited to the attached drawing (appendix 6), and
                  forming part of the premises let to the latter under the terms
                  of the lease concluded with Diaclone on December 8th, 2003.

         The manager of the present company shall alone be responsible for these
premises complying with statutory and regulatory provisions governing the
activities which are to be carried out there.

         The rents, common charges and other property expenses relating to the
premises provided in this way shall be charged to the joint venture, pro rata
based on the areas concerned, i.e.:

         o        for the BEYNOST site, all of the premises designated in rider
                  n(degree)3 of the lease

         o        for the BESANCON site, part of the premises designated in the
                  lease concluded with Diaclone on December 8th, 2003.

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         The same shall apply for all ancillary costs, in particular insurance
premiums, consumption of electricity, water and heating, running maintenance and
repair costs and the land tax passed on to the tenant.

ARTICLE 7 - EMPLOYEES

         Appendix 3 contains a list of the employees of each of the party
companies, currently in the branch of activity which the party is contributing
and who will be allocated to the running of the present company.

         In this respect, it is hereby stated that Mr. Michel MAIRAUT and Mr.
Vincent BRUN who are responsible for the equipment maintenance at the Besancon
site and who, in this quality, are not exclusively assigned to the activity
provided in use to the joint venture, shall not be considered as part of the
said branch of activity.

         In this respect, it is agreed that Mrs. Marielle MAURICE, Mylene
GRISONI, Barbara GOUGET and Nona GHAZANFARI who work in connection with the
GENOPOIETIC's proper activity developed on the Beynost site and who, in this
quality, are not exclusively assigned to the activity provided in use to the
joint venture, shall not be considered as part of the said branch of activity.

         When the present company is wound up, for whatever reason this may be,
each party company shall return to its service those of its employees allocated
to the joint operation, including during the lifetime of the company.

         The training costs of the employees working in the business provided by
each party to the joint venture shall be borne by OGP itself.

ARTICLE 8 - BUDGETS - LIQUIDITY

         8.1. Appendix 4 contains the forecast results account of the company
for its first year of operation, from February 1st, to December 31st, 2004. This
account includes 50% of the remuneration allotted to Mr Andres CRESPO, president
of GENOPOIETIC, which is manager of the joint venture, and all taxes and
associated social security contributions pertaining to this remuneration.

         This budget corresponds to (euro)1,550,310 for the period running up
to December 31st, 2004.

         GENOPOIETIC undertakes to participate to this budget with a minimum of
(euro) 332,210 for the first 11 months of operation, from February to December
2004.

         OPISODIA undertakes to participate to this budget with a minimum of
(euro) 1,218,000 for the first 11 months of operation, from February to December
2004.

         8-2. Liquidity requirements associated with the operation of the joint
venture shall be covered by each party pro rata to their share in the company's
forecast results.

         For this purpose, for the financial year commencing on February 1st,
2004, each party undertakes to pay into the joint account, by no later than the
first day of each month, the following sums:

         o        for GENOPOIETIC,(euro)30,2014, (i.e. 21,43% of the budget),

         o        for OPISODIA,(euro)110.736 (i.e. 78,57% of the budget).

         These contributions have been determined on the basis of estimated
costs on the basis of the employees directly allocated to the activities carried
out jointly on behalf of each party to the joint venture for its own
productions. In Appendix 7, is attached the breakdown chart of costs and time
for the budget of the financial year open on February 1st, 2004. This chart may
be revised at any time by agreement between the two parties, depending on the
development of the operations carried out by the company, either on behalf of
the partners or on behalf of third parties.

         The parties may together agree conditions at which loans, the opening
of credits or cash facilities may be entered into by one of them or by each of
them, in order to cover the working capital needs of the joint venture; the
financial cost thereof shall be borne by the joint venture.

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         In the relations the parties have with each other, they shall be
responsible for the financial commitments of the joint venture, and likewise any
sureties or securities which may be given to guarantee its commitments, at the
proportion set for sharing the company's results.

         The contributions to the working capital shall not give rise to any
interest on their sums insofar as they are provided pro rata to the percentage
of each party in the company's results. If the contribution of one of the
parties should be greater than its percentage, then at the end of the financial
year, this party shall have the right to take PER PRAECIPIUM, from the results
of the joint venture, interest calculated at a rate of 4%, on the sum of its
extra payments.

         Unless the two parties decide otherwise, the credit or debit balance of
the "Manager liaison" account shall bear interest at the rate of 4%.

         8-3. In case either party fails to its contribution obligation above
mentioned, the other party may, at its own choice, either apply the provisions
of article 17 of this act, or:

         -        receive, as a compensation for its damage, an interest at a
                  rate of 7% per year on the unpaid contributions due by the
                  other party;

         -        pre-empt, as a compensation, the tangible or intangible assets
                  (equipment, know-how, right to the lease, etc.) contributed
                  for use to OGP by the failing party, this option to pre-empt
                  being considered for the said party as a firm promise to
                  transfer the said assets for a value equivalent to the net
                  book value, 20 (twenty) worked days at the latest, as from the
                  notification made in accordance with article 17.1 below;

ARTICLE 9 - MANUFACTURING CONTRACTS WITH THIRD PARTIES

         9.1. If the joint venture, at the request of either of the parties and
with the agreement of the executive committee, should enter into manufacturing
contracts with third parties, the company's budget and the contribution of each
party to cover the necessary working capital (as set in article 8-2) shall be
revised by the executive committee to take account, if applicable, of additional
costs incurred by the execution of these contracts.

         To illustrate this operating rule between the parties hereto is
attached in Appendix 8, two samples of adjusted budgets, the one for a project
of (euro)200,000 with a 50% net margin and the other for a (euro)1,000,000
with a net margin of 40%.

         9.2. If a manufacturing contract prompts new investment, the financing
of which is not covered by the third party, it shall, unless otherwise agreed,
be financed by the one of the two party companies which concluded this contract,
and rented out by it to the joint venture, at a rent equal to the normal
accounting depreciation of this equipment plus 10%.

ARTICLE 10 - MANAGEMENT

         OGP shall be managed and administered by GENOPOIETIC which shall alone,
on behalf of the joint venture, act, enter into contracts, make undertakings and
honour the commitments of the latter with regard to third parties.

         In its capacity as manager of OGP, GENOPOIETIC shall be responsible for
all issues related with security, business operation and environment of the
sites and shall get the proper insurance whose premium shall be, in the same
proportion, paid by the joint venture.

         The manager shall justify of such insurance at first demand of the
partners.

         GENOPOIETIC shall act via its bodies duly authorised for this purpose,
in accordance with its articles of association.

         50% of the sum of the remuneration of Mr Andres CRESPO, president of
GENOPOIETIC, and the associated taxes and social security contributions, shall
be charged to the company. In return, GENOPOIETIC shall not be entitled to any
remuneration for its role as manager.

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ARTICLE 11 - ACCOUNTS - ADMINISTRATIVE OBLIGATIONS

         The managing company shall keep regular accounts of the operations
carried out as a joint venture,

         These accounts shall be held at the registered office of the managing
company and the representatives of the other party and likewise the auditors of
the two parties can peruse, but not remove, all accounting documents and all
supporting documentation.

         The managing company shall, at the appropriate time, make all the
fiscal declarations relating to the joint venture operations.

         One or more bank accounts shall be opened by the manager under the name
"OGP" for the exclusive needs of operating OGP. To facilitate the handling of
practical aspects, Mr. Andres CRESPO, in its capacity as legal representative of
the manager, shall give a proxy to an employee of GENOPOIETIC.

ARTICLE 12 - EXECUTIVE COMITTEE

         12-1. An executive committee shall be composed jointly of the legal
representatives of the two parties or their deputies.

         Each member of this committee may invite any people he sees fit to
attend these meetings, but they shall not have a vote.

         12-2. This committee shall meet at the initiative of the manager of the
joint venture, whenever he sees fit and or upon request of the monitoring
committee mentioned at article 12.5 of these articles, and, in any event, within
the month following the end of each calendar quarter.

         At these meetings, a report shall be presented about the joint
operation, the results obtained, difficulties encountered and prospects. The
committee may furthermore reach decisions or give authorisations as necessary as
detailed below.

         12-3. The executive committee alone is competent to:

         o        decide on and revise each annual budget,
         o        modify the parties' contributions to cover the company's
                  working capital requirement,
         o        authorise the conclusion of all manufacturing contracts with
                  third parties,
         o        decide on any investment of a sum in excess of (euro) 1,000
                  excluding taxes which is to be allocated to the operation of
                  the joint venture (this investment being implemented by either
                  of the two parties, as agreed between them),
         o        make any modification regarding the employees allocated to the
                  operation of the joint venture,
         o        decide on the allocation to the operation of the present joint
                  venture, of any employee other than those mentioned in
                  appendix 3 (including any employee subsequently taken on by
                  either of the two parties),
         o        decide to dismiss an employee of OPISODIA allocated to the
                  joint operation,
         o        decide on or change the consideration granted in return for
                  all services provided by either of the two parties and posted
                  to the joint account.
         o        Decide the re-location of any of the equipments;

         12-4. Minutes of the executive committee meetings shall be produced by
the manager within 10 worked days following the meeting. Decisions reached by
the committee in application of the above shall not be implemented until these
minutes have been signed by the representatives of the two parties.

         12-5. Moreover, in the view of preparing the decisions of the executive
committee, a monitoring committee composed jointly of two representatives of
each party including its legal representative or its deputy, shall meet whenever
it is necessary and, in any event, within the first fifteen days of each month.
The committee shall be monthly informed in writing of:

         -        the allocation of staff directly attributed to the
                  manufacturing activities;

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         -        the cash position;

         -        the proposal from third parties (subcontracting activities)

         -        the progress of ongoing projects.

ARTICLE 13 - INVENTORY - DETERMINATION OF RESULTS

         13-1. The managing company shall produce, to 31 December of each year,
and for the first time to 31 December 2004, an inventory, a statement of the
assets and liabilities of OGP, and a results account.

         13-2. The expenses of the joint venture shall include costs exclusively
attributable to the operation of OGP, taking into account in particular the
conditions of the parties' contributions as stated in article 5 and, with regard
to financial costs, the rules set in article 8.

         The following in particular shall be charged to the joint venture :

         o        the wages and the costs and taxes based on the wages for the
                  employees allocated to the joint operation,

         o        property costs with regard to the premises made available to
                  the joint venture, as stated in article 6,

         o        purchases and other external expenses once they are allocated
                  to the joint operation,

         o        expenses associated with the management of the present
                  company, as stated in article 10,

         o        the share of the local tax on business activities declared by
                  the managing company and based on the fixed assets made
                  available to the joint venture,

         o        the services rendered by GENOPOIETIC's employees not dedicated
                  to the joint venture (cf. article 7) paid at direct cost
                  majored of a 1,1 factor;

         o        the services rendered by OPISODIA's employees or Opi or
                  Diaclone's ones, not dedicated to the joint venture (cf.
                  article 7) paid at direct cost majored of a 1,1 factor;

         The company proceeds shall include all the proceeds coming from
manufacturing contracts concluded by either of the two parties with third
parties.

         13-3. In RIDER 10 AND 11, are listed the consumable and raw materials
transferred to OGP as of February 1st, 2004, by OPI or OPISODIA on the one hand
or GENOPOIETIC on the other hand.

ARTICLE 14 - APPROVAL OF THE ACCOUNTS - DISTRIBUTION OF RESULTS

         14-1. The accounts produced by the managing company shall be submitted
for the approval of the parties, ruling unanimously, within 2 months of the
closure of each financial year.

         Unless otherwise agreed, profits and losses shall be distributed
between the parties hereto in the same arithmetic proportion of the cost of the
employees (noticed during each financial year and reported monthly as stated in
article 12.5) allocated to the manufacturing and quality control activities
conducted jointly on behalf of each party for their own productions.

         The debit or credit situation of each of the two party companies with
regard to OGP shall be settled within eight days of the approval of the joint
accounts, allowing for any payments it may have made to cover the company's
financial requirements in the past financial year.

         Each party shall be personally liable for corporation tax and any
additional contributions on its share of the profits.

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         14-2. When the company ends or if it should be prematurely wound up,
the accounts shall be produced and submitted to the parties within the same
periods and at the same conditions.

         The results, be they profits or losses, shall be distributed between
the parties at the proportions set in paragraph 13-1. above.

ARTICLE 15 - NON-COMPETITION

         Throughout the duration of the joint venture, the parties undertake not
to exercise any activity which competes with that of the company.

ARTICLE 16 - TRANSFER OF RIGHTS

         Neither party may sell or contribute to another company, in whole or in
part, its rights in the company other than with the approval of the other party.
Any sale must be confirmed in writing and is rendered opposable to the other
party in the forms provided in article 1690 of the Civil Code.

         OGP shall not be wound up in the event of a merger by absorption of
either of the party companies, but shall continue with the other party and the
absorber company.

ARTICLE 17 - WINDING-UP - LIQUIDATION

         17-1. The company shall end:

         o        by the accomplishment or disappearance of its purpose,

         o        by notification by either of the parties, in accordance with
                  the conditions and by the deadlines provided in article 3, to
                  terminate the company at the end of its initial period or each
                  renewal period,

         o        if wound up prematurely

         o        as decided by common agreement between the two parties,

         o        by the decision of just one of the two parties if the other
                  has not paid at the due date, its contribution to cover the
                  working capital requirement, as provided in article 8-2 or
                  revised by common agreement, and if it has not settled its
                  position within a period of 40 (forty) days following a formal
                  notice by the other party by registered letter with
                  acknowledgement receipt.

         o        automatically, unless otherwise agreed by the parties, if, at
                  least one months before the start of each calendar year, OGP's
                  budget for the said year, has not been decided by the
                  executive committee or if the accounts have not been approved
                  by the parties hereto within the period of time mentioned at
                  article 14.1.

         o        if wound up by the court at the conditions set in article
                  1844-7-5(degree)and 6(degree)of the Civil Code.

         17-2. When OGP comes to an end, including the case it is wound up
prematurely, the accounts will be settled on the basis of an inventory which is
then to be drawn up by common agreement between the parties.

         Each party company shall withdraw, from the date on which it is wound
up, the free disposal of the tangible and intangible fixed assets which it has
made available to OGP, without being obliged to pay any compensation for the
added value which may have been acquired by these items, and likewise without
being able to claim any compensation for any depreciation which may affect them.

         Before any distribution of the net result of the liquidation at the
proportions stated in article 14.1, the cash advances which the parties may have
made to the company in application of article 8 will be repaid to them, without
any preference shown to either of them.

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         17-3. When OGP comes to an end, including the case it is wound up, each
party shall take back into its service and on its account those of its employees
who were allocated to the joint operation, a list of them being provided in
appendix 3, and likewise those who are allocated subsequently, by decision of
the executive committee. Consequently, it shall decide whether to continue or to
end their employment contracts.

                      MISCELLANEOUS OR TEMPORARY PROVISIONS

ARTICLE 18 - ARBITRATION CLAUSE

         Any dispute between the party companies regarding the interpretation or
execution of the memorandum or articles of association of the joint venture
shall be settled by a court of arbitration.

         The court of arbitration shall be composed of three arbitrators, two of
whom to be appointed by the plaintiff and defendant within ten (10) working days
of the notification by the plaintiff to the defendant, by registered post with
acknowledgement of receipt, of its intention to have recourse to arbitration.
The two arbitrators shall themselves appoint an additional arbitrator within ten
(10) working days of the appointment of the second of them.

         If, within the above deadlines, an arbitrator is not appointed by
either of the party companies or the additional arbitrator is not appointed, the
presiding judge of the LYONS Commercial Court shall be competent to make this
appointment at the request of either of the parties.

         A matter is brought before the court of arbitration without any need
for a prior arbitration agreement, by registered letter with acknowledgement of
receipt, setting out the subject of the dispute and sent by the plaintiff to the
defendant and to each of the arbitrators.

         The court of arbitration shall sit in LYONS and shall rule within a
period of three months from the date on which a matter is brought before it,
unless the option of extending this period is taken subject to statutory
conditions.

         The court of arbitration shall not be bound by procedural rules. It
shall rule as an amicable arbitrator. Its decision shall be duly motivated and
no appeal may be made against it.

         The costs of arbitration shall be borne by the parties to the dispute
at conditions which the court of arbitration shall have sovereign authority to
decide.

         Notwithstanding the provisions of the present article, each party
company may, in the event of urgency, apply to the ordinary courts for
protective measures, without this application resulting in any renunciation of
arbitration.

ARTICLE 19 - COSTS OF CONSTITUTION

         The costs, duties and fees incurred in connection with the creation of
OGP shall be borne by OGP. The parties hereto shall keep the fees engaged in
connection with the preparation of these articles of association.

ARTICLE 20 - ELECTION OF DOMICILE

         For the complete execution of the presents, GENOPOIETIC and OPISODIA
each elect domicile at their registered offices as stated in the heads to the
presents.

Done in three originals, one being for registration,

at Dardilly on January 29, 2004

For GENOPOIETIC                                                     For OPISODIA
Andres CRESPO                                                    Gilles ALBERICIExhibit 4.1
                                                                     -----------
                                   Amendment 1
                              PCS U. S. Employees'
                                  Savings Plan
                        (Effective as of January 1, 1999)

Whereas, PCS Administration (USA), Inc. ("Sponsor") is the sponsor of the PCS U.
S. Employees' Savings Plan ("U. S. Plan");

Whereas, PCS Nitrogen Inc. is the sponsor of the PCS Nitrogen 401(k) Savings
Plan ("Nitrogen Plan");

Whereas, certain former participants in the Nitrogen Plan are now eligible to
participate in the U. S. Plan;

Whereas, Moab Salt, Inc., an Employer under the U. S. Plan has been sold; and

Whereas, the Sponsor desires to amend the Plan to reflect recent IRS rules and
to otherwise clarify the U. S. Plan;

Now, Therefore, Be It Resolved, that the U. S. Plan is amended as follows,
effective as of January 1, 1999 unless provided otherwise:

1.   The first sentence of section 4.5 (concerning matching contributions) is
     amended by replacing "for the entire Plan Year" with "for each payroll
     period", and by amending the first sentence of the second paragraph to read
     as follows:

    "The Employer Matching Contributions shall be credited to the Participant's
     Employer Matching Contributions Account and shall be paid to the Trustee
     monthly to the extent practicable, but in no event later than the earlier
     of--

     (a)  the time required for the filing of the Employer's federal income tax
          return for its fiscal year in which the applicable Plan Year ends,

     (b)  12 months after the close of the Plan Year, or

     (c)  for Employer Matching Contributions relating to Before-Tax or
          After-Tax Employee Contributions made after May 1, 2000, the last day
          of the calendar quarter that follows the calendar quarter in which
          such Employee Contributions were made."

2.   Subparagraph (B) of section 4.8(f) shall be reformatted so that it appears
     as follows:

     "(B) the Actual Contribution Percentage for the group of Highly Compensated
          Employees who are Eligible Employees

     shall not exceed the Aggregate Limitation described in paragraph (2)."

3.   The last sentence of the second paragraph of section 5.1(a) (concerning the
     Company Stock Fund) is amended by replacing "if such person (1) is not the
     Company, an Affiliate, or any Employee" with "if such person (1) is not the
     Sponsor, an Affiliate, or any Employee".

4.   In section 6.3(a), the last sentence of the second paragraph is amended to
     read as follows:

    "Stock may be distributed only if the Participant elects a Lump Sum
Distribution."

5.   Appendix A (listing the participating Employers) is amended by striking
     "Moab Salt, Inc." and replacing it with "Moab Salt, Inc., effective January
     1, 1999 to February 18, 2000."

6.   The Plan is amended by adding the following new Supplement:

   "Supplement C. PCS Nitrogen, Inc.

     C.1  Asset Transfer; Transfer Accounts

     (a)  In General. Effective January 1, 2000, the account balances of those
          Eligible Employees of PCS Nitrogen, Inc. that were held under the PCS
          Nitrogen 401(k) Savings Plan ("Nitrogen Plan") were transferred to
          this Plan. These account balances shall be credited to the appropriate
          Before-Tax, After-Tax, and Rollover Accounts under this Plan. The
          amounts credited to the employer contributions account under the
          Nitrogen Plan shall be credited to a separate account ("Transfer
          Account") under this Plan. The Transfer Account includes qualifying
          employer securities ("Company Stock") as defined in ERISA section
          407(d)(5) that had been originally acquired through a loan to a
          predecessor of the Nitrogen Plan, the Arcadian Corporation Employee
          Stock Ownership Plan ("ESOP") and then replaced by stock of Potash
          Corporation of Saskatchewan upon that Corporation's acquisition of
          Arcadian Corporation, later renamed PCS Nitrogen, Inc. The loan
          satisfied the requirements of ERISA section 408(b)(3) and Code section
          4975(d)(3) for a loan to a plan made by, or guaranteed by, a
          disqualified person and has been fully discharged.

     (b)  Vesting. The Transfer Account described in this Supplement is fully
          vested in the case of a person who is an Employee of the Sponsor or an
          Affiliate on January 1, 2000.

     (c)  In-Service Withdrawals. Amounts credited to the Transfer Account may
          be withdrawn or distributed only if the Participant terminates
          employment, becomes Disabled, attains age 59 1/2, or satisfies the
          requirements of section 7.4 (relating to hardship withdrawals).

     (d)  Investment Direction. A Participant may elect to sell Company Stock
          and transfer the proceeds to another investment pursuant to section
          5.1(c).

     (e)  Distribution Methods; Right to Demand Stock Distribution. The
          applicable form of payment under section 6.3(a) shall also apply to
          the Transfer Account. However, notwithstanding section 6.3(a), a
          Participant may elect to receive a distribution from the Transfer
          Account in the form of Company Stock or cash, or both, and may receive
          Company Stock notwithstanding the election of an Installment Payout.
          The preceding sentence does not apply to the extent that Company Stock
          has been sold pursuant to a Participant's investment direction under
          subsection (d).

     (f)  Special ESOP Rules.

          (1)    Nonterminable Protections and Rights. Except as provided in
                 paragraph (2) or by law, no Company Stock credited to the
                 Transfer Account may be subject to a put, call, or other
                 option, or buy-sell or similar arrangement when held by and
                 when distributed by the Trust Fund. The protections and rights
                 granted by this paragraph and the put option rights granted by
                 paragraph (2) are nonterminable, and such protections and
                 rights shall continue to exist under the terms of this Plan so
                 long as any Company Stock credited to the Transfer Account is
                 held by the Trust Fund or by a Participant or other person for
                 whose benefit such protections and rights have been created.

          (2)    Put Option If Stock is not Readily Tradable.

                 (A)    In General. When Company Stock is distributed to a
                        Participant, the Participant shall have the right to
                        require the Employer to repurchase such Company Stock
                        pursuant to subparagraph (C) under a fair valuation
                        method as described below if--

                       (i)    the Company Stock is not readily tradable on an
                              established securities market when distributed, or

                       (ii)   the Company Stock is subject to a trading
                              limitation.

                        A trading limitation is a restriction under a Federal or
                        State securities law or an agreement (not prohibited by
                        paragraph (1)) affecting the Company Stock so that it is
                        not as freely tradable as stock not subject to such
                        restriction.

                        An arrangement involving the Plan that creates a put
                        option must not provide for the issuance of put options
                        other than as provided under this section. The Plan (and
                        the Trust Fund) must not otherwise obligate itself to
                        acquire Company Stock from a particular holder thereof
                        at an indefinite time determined upon the happening of
                        an event such as the death of the holder.

                 (B)    Fair Valuation. Valuations must be made in good faith
                        and based on all relevant factors for determining the
                        fair market value of securities. In the case of a
                        transaction between a Plan and a disqualified person,
                        value must be determined as of the date of the
                        transaction. For all other Plan purposes, value must be
                        determined as of the most recent valuation date under
                        the Plan. An independent appraisal will not in itself
                        be a good faith determination of value in the case of a
                        transaction between the Plan and a disqualified person.
                        However, in other cases, a determination of fair market
                        value based on at least an annual appraisal
                        independently arrived at by a person who customarily
                        makes such appraisals and who is independent of any
                        party to the transaction will be deemed to be a good
                        faith determination of value. Company Stock not readily
                        tradable on an established securities market shall be
                        valued by an independent appraiser meeting requirements
                        similar to the requirements of the regulations
                        prescribed under Code section 170(a)(l).

                        For purposes of this Plan, the term "disqualified
                        person" means a person who is a fiduciary, a person
                        providing services to the Plan, an Employer any of whose
                        Employees are covered by the Plan, an employee
                        organization any of whose members are covered by the
                        Plan, an owner, direct or indirect, of 50 percent or
                        more of the total combined voting power of all classes
                        of voting stock, or an officer, director, 10 percent or
                        more shareholder, or a Highly Compensated Employee.

                 (C)    The Put Option. The put option must be exercisable only
                        by a Participant, by the Participant's donees, or by a
                        person (including an estate or its distributee) to whom
                        the Company Stock passes by reason of a Participant's
                        death. For the purpose of this section, the term
                        "Participant" means a Participant and the Beneficiaries
                        of the Participant.) The put option must permit a
                        Participant to put the Company Stock to the Employer.
                        Under no circumstances may the put option bind the
                        Plan. However, the put option shall grant the Plan an
                        option to assume the rights and obligations of the
                        Employer at the time that the put option is exercised.

                        If it is known at the time the Common Stock is acquired
                        through a loan that Federal or State law will be
                        violated by the Employer's honoring such put option, the
                        put option must permit the Company Stock to be put, in a
                        manner consistent with such law, to a third party (e.g.,
                        an affiliate of the Employer or a shareholder other than
                        the Plan) that has substantial net worth at the time the
                        loan is made and whose net worth is reasonably expected
                        to remain substantial.

                 (D)    Duration of the Put Option. The put option shall
                        commence as of the day following the date the Company
                        Stock is distributed to the Participant and end 60 days
                        thereafter. If the option is not exercised within such
                        60-day period, an additional 60-day option shall
                        commence on the first day of the fifth month of the
                        Plan Year next following the date the Company Stock was
                        distributed to the Participant (or such other 60-day
                        period as provided in the regulations). However, in the
                        case of Company Stock that is publicly traded without
                        restrictions when distributed but ceases to be so
                        traded within either of the 60-day periods described
                        above after distribution, the Employer must notify each
                        holder of such Company Stock in writing on or before
                        the tenth day after the date the Company Stock ceases
                        to be so traded that for the remainder of the
                        applicable 60-day period the Company Stock is subject
                        to the put option. The number of days between the tenth
                        day and the date on which notice is actually given, if
                        later than the tenth day, must be added to the duration
                        of the put option. The notice must inform distributees
                        of the terms of the put options that they are to hold.
                        The terms must satisfy the requirements of this
                        paragraph.

                        The period during which a put option is exercisable does
                        not include any time when a distributee is unable to
                        exercise it because the party bound by the put option is
                        prohibited from honoring it by applicable Federal or
                        State law.

                 (E)    Exercise of the Option and Exercise Price. The holder of
                        the put option shall notify the Employer in writing that
                        the option is being exercised. The notice shall state
                        the name and address of the holder and the number of
                        shares to be sold. The exercise price of the option is
                        the fair value of the Company Stock determined in
                        accordance with subparagraph (B). Payment under a put
                        option must not be restricted by the provisions of a
                        loan or any other arrangement, including the terms of
                        the Employer's articles of incorporation, unless so
                        required by applicable state law.

                 (F)    Payment for Total Distribution. Payment under the put
                        option involving a "Total Distribution" shall be paid in
                        substantially equal monthly, quarterly, semiannual or
                        annual installments over a period certain beginning not
                        later than 30 days after the exercise of the put option
                        and not extending beyond five years. Adequate security
                        shall be provided and a reasonable interest rate
                        charged.

                        A Total Distribution means a distribution to a
                        Participant within one taxable year of the entire vested
                        amount of his or her Accounts in the Plan.

                 (G)    Payment for Installment Distributions. The amount to be
                        paid under the put option involving installment
                        distributions must be paid not later than 30 days after
                        the exercise of the put option."

It Is Further Resolved that the appropriate officers of the Sponsor are
authorized to execute whatever additional documents, and to take whatever
actions, are necessary or advisable to clarify and implement the foregoing
revision and to satisfy applicable legal requirements.

                          * * * * * * * * * * * * * * *

PCS Administration (USA), Inc. adopted the foregoing amendment on the 1st day of
January, 2000.

                                             PCS Administration (USA), Inc.

                                             By:   /s/ James H. Heppel
                                                   ----------------------------
                                                   VP Human Resources
                                                   ----------------------------

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