Document:

FINANCING COMMITMENT

                                       FOR

                               CEC RESOURCES LTD.

This Financing Commitment constitutes the whole and entire agreement between the
Borrower,  CIBC  and  PLC and  cancels  and  supersedes  any  prior  agreements,
undertakings,  declarations,  representations and warranties, written or verbal,
among the parties in respect of the subject matter of this Financing Commitment,
including any prior Financing Commitment or arrangements.

--------------------------------------------------------------------------------

                                                              SEPTEMBER 15, 2000

BORROWER:                   CEC Resources Ltd. (the "Borrower")
---------

LENDER:                     Canadian Imperial Bank of Commerce ("CIBC")
-------

GAS PURCHASE AND
SALE TRANSACTIONS
FACILITATOR:                CIBC World Markets PLC or any other subsidiary of
------------                CIBC from time to time ("PLC")

CONFIDENTIALITY:            This Financing  Commitment  will be treated in
----------------            confidence by the Borrower,  CIBC and PLC unless
                            disclosure is required by law or other reporting or
                            disclosure requirements.

AMOUNT:                     Cdn. $6,600,000 as a revolving/term production loan
-------                     (the "Production Loan") and, U.S. $3,000,000 as a
                            swap facility (the "Swap Facility")
                            (collectively, the "Facility").

PURPOSE OF
THE FACILITY:               Production Loan

                            For normal operating  requirements and to assist the
                            Borrower in the exploration, development, production
                            and/or  acquisition  of  oil  and  gas  reserves  in
                            Western Canada.

                            Swap Facility

                            To provide for the  Borrower's  contingent  exposure
                            under   commodity   swaps  either   financially   or
                            physically settled.

HOSTILE
ACQUISITION:                The Borrower shall not utilize  whether  directly or
                            indirectly  Availments  to  facilitate,   assist  or
                            participate  in a hostile  acquisition  without  the
                            prior written  consent of CIBC which may be withheld
                            in CIBC's sole discretion.
<PAGE>

BORROWING BASE:             Subject to the satisfaction of the Conditions
---------------             Precedent to Funding,  the Production Loan currently
                            permits draws of up to Cdn. $6,600,000,  (the
                            "Borrowing Base") subject to adjustment as herein
                            provided, and will remain in effect until expiration
                            of the Revolving Phase.

                            CIBC  will  undertake  at any  time,  but  not  less
                            frequently than  semi-annually  during the Revolving
                            and Term phase if CIBC so  chooses,  a review of the
                            Borrower's  oil and gas  properties  evaluated in an
                            independently    prepared   economic   and   reserve
                            evaluation  report (provided  annually) for purposes
                            of  redetermining  the Borrowing Base  applicable to
                            the Facility. To assist in such redetermination, the
                            Borrower will provide to CIBC  operating  statements
                            and such other technical information with respect to
                            the properties being reviewed as CIBC may request.

                            Should  CIBC  determine  at any time that there is a
                            Borrowing Base Shortfall,  during both the Revolving
                            Phase and the Term Phase, the Borrower will,  within
                            60 days, use whatever means  necessary to reduce its
                            indebtedness under this Financing Commitment by that
                            amount  stipulated by CIBC, or alternatively  pledge
                            additional  security to CIBC sufficient to cover, in
                            CIBC's opinion, such deficiency.

                            While a Borrowing Base Shortfall exists, the
                            Borrower shall:

                            *    not request new Availments,  except for the
                                 rollover or conversion of a then maturing
                                 Availment for a term not exceeding 30 days;

                            *    provide CIBC with information needed to
                                 determine the Borrower's Available Cash Flow;

                            *    dedicate on a monthly  basis for  repayment  of
                                 this Financing  Commitment  such portion of its
                                 Available Cash Flow as is required to eliminate
                                 the  Borrowing  Base  Shortfall  within 60 days
                                 from  the  date  CIBC  delivers  notice  to the
                                 Borrower of the Borrowing Base Shortfall; and

                            *    pay the increased  compensation  required under
                                 the heading  "Borrowing  Base Rate Shortfall or
                                 Event of Default".

PRODUCTION LOAN
AVAILABILITY:               The Production Loan can be advanced by way of any
-------------               combination of the following availments:

                            *    overdraft borrowings in Canadian dollars;

                            *    letters of credit, letters of guarantee, cheque
                                 credits,  bid cheques for out of Province  land
                                 sales  and  corporate  visa  (collectively  the
                                 "Sundry Options").

SWAP FACILITY
AVAILABILITY:               At the  Borrower's  request  and  subject  to market
                            availability,  CIBC and/or PLC will  provide  quotes
                            for i) forward rate  agreements  to provide fixed or
                            floating  rate  funding  for  part  or  all  of  the
                            Production  Loan  ii)  commodity  swaps  covering  a
                            portion of the  Borrower's  oil and gas  production,
                            iii)  forward  exchange  contracts  and iv) firm gas
                            purchase  and  sale  transactions,  subject  to  the
                            following:
<PAGE>

                           o        Forward  Rate  Agreements  - terms shall not
                                    exceed  the lesser of two years and the date
                                    of expiry or  termination  of the Production
                                    Loan,  with aggregate  amounts hedged not to
                                    exceed   60%   of  the   average   Principal
                                    Indebtedness    outstanding    during    the
                                    Borrower's previous fiscal quarter;

                           o        Commodity Swaps - terms shall not exceed the
                                    lesser  of two  years and the date of expiry
                                    or termination of the Production  Loan, with
                                    aggregate production volumes hedged from all
                                    sources,  for  both  natural  gas  and  oil,
                                    (calculated  separately,  not  collectively)
                                    not to exceed 60% of the Borrower's  average
                                    production as forecast by CIBC.

                           o        Forward Exchange Contracts - terms shall not
                                    exceed  the lesser of two years and the date
                                    of expiry or  termination  of the Production
                                    Loan,  with aggregate  amounts hedged not to
                                    exceed  60%  of  the  Borrower's  applicable
                                    foreign revenue;

                           o        Physical Gas Purchase and Sale  Transactions
                                    - terms and  conditions  as  outlined in the
                                    Master  Firm  Gas  Purchase/Sale  Agreement,
                                    terms  shall not  exceed  the  lesser of two
                                    years and the date of expiry or  termination
                                    of  the  Production   Loan,  with  aggregate
                                    production  volumes  hedged from natural gas
                                    not to exceed 60% of the Borrower's  current
                                    daily  production  volume as  determined  by
                                    CIBC;

                            provided  that  in  all  instances,  the  Borrower's
                            contingent  liability  to CIBC  and/or PLC under the
                            Swap  Facility  shall be secured and rank pari passu
                            with the Principal Indebtedness.

                            Notwithstanding  the  foregoing,   the  sum  of  the
                            aggregate production volumes hedged with CIBC and/or
                            PLC from natural gas under both the commodity  swaps
                            and  physical  gas  purchase  and sale  transactions
                            described  above shall not at any time exceed 60% of
                            the Borrower's  current daily production  volumes of
                            natural gas as determined by CIBC.

TERM AND
REPAYMENT:                  The  Production  Loan will revolve and  fluctuate at
                            the  Borrower's  option until December 31, 2000 (the
                            "Revolving  Phase") with interest payable monthly in
                            arrears.  At  the  request  of  the  Borrower,   the
                            Production  Loan may be renewed  upon such terms and
                            for such  period,  and  subject to the  requirements
                            listed below, as CIBC may in its discretion agree to
                            (a "Revolving Period").  CIBC may elect to renew all
                            or  only a  portion  of the  Production  Loan  for a
                            further Revolving Phase.

                            Revolving Phase

                            While the Production Loan is in the Revolving Phase,
                            the  Borrower  may,  at least  60 days  prior to the
                            termination  of the then  current  Revolving  Phase,
                            request  an   extension  of  the   Revolving   Phase
                            provided:

                            * the extension is for 364 days or less;

                            * the extension will not result in the then current
                              Revolving Period extending beyond 364 days; and

                            * CIBC, in its unrestricted discretion,  consents to
                              the extension.
<PAGE>

                            An  extension of the  Revolving  Phase will create a
                            new and separate  Revolving  Phase which in turn can
                            only be extended as provided above.

                            Upon  the  expiration  or  termination  of the  then
                            current  Revolving  Phase,  any amount undrawn under
                            the Production Loan will be permanently cancelled.

                            Term Phase

                            During the Term Phase,  the Production  Loan will be
                            permanently  reduced by way of  consecutive  monthly
                            principal payments  commencing 30 days after the end
                            of the Revolving Phase over an  amortization  period
                            consistent with the Borrower's cash flow profile, as
                            determined by CIBC,  by applying its usual  practice
                            for similar type loans in comparable  circumstances,
                            provided  that such  amortization  period  shall not
                            exceed 36 months.

                            Where used  herein,  the term "Term Phase" means the
                            period  commencing  immediately after the end of the
                            "Revolving  Phase" until repayment of the Production
                            Loan in full.

PREPAYMENT AND
CANCELLATION:               The Borrower may permanently prepay the Facility in
-------------               whole or in part, subject to the following:

                            *    All prepayments, during the Term Phase, will be
                                 made in inverse order of maturity;

                            *    Availments by way of commodity swaps (financial
                                 or  physical),   forward  rate  agreements  and
                                 forward exchange  contracts may be prepaid only
                                 at maturity except where the Borrower agrees to
                                 pay   CIBC's   breaking   costs  due  to  early
                                 redemption   of    offsetting    positions   or
                                 otherwise,  including all costs associated with
                                 reversing   positions,   provided   such  early
                                 redemption is possible; and

                            *    the Borrower may at any time,  upon giving CIBC
                                 two  Banking  Days  prior  notice,  cancel  any
                                 unused part of the Facility  and any  cancelled
                                 portion will not be reinstated.

RATES AND
STAMPING FEES:              Revolving Phase

                            *    CIBC Prime Rate in effect from time to time
                                 plus 3/4 of 1% per annum with interest  payable
                                 monthly in arrears.

                            Term Phase

                            *    CIBC Prime Rate in effect  from time to time
                                 plus 1 3/4% per annum with  interest  payable
                                 monthly in arrears.

STANDBY FEE:                During the Revolving  Phase, a Standby Fee of 1/4 of
------------                1% per annum calculated on the undrawn portion of
                            the available and unused Production Loan is payable
                            monthly in arrears.

RENEWAL FEE:                $5,000 is payable upon the Borrower's acceptance of
------------                the terms and conditions hereof.

<PAGE>

SUNDRY OPTIONS:             Fees on Sundry Options are subject to change without
---------------             notice and are payable as follows:

                            Letters of Credit/     -   1.3% per annum or portion
                                                       thereof in advance
                            Letters of Guarantee   -   with a minimum of $150
                            Corporate Visa         -   CIBC standard rates
                            Bid Cheques                2.0% per annum  plus
                                                       $10.00 per cheque for out
                                                       of  province  Bid  Cheque
                                                       transactions

BORROWING BASE
SHORTFALL OR
EVENT OF  DEFAULT:          Effective on the 30th day  following  receipt by the
                            Borrower of a notice of a  Borrowing  Base Shortfall
                            or an Event of  Default (the "Effective  Date"), the
                            interest rates  then  applicable  to CIBC Prime Rate
                            loans  shall increase  by  2%  per  annum  and  such
                            increase shall  remain  in  effect  for as long as a
                            Borrowing  Base   Shortfall   or  Event  of  Default
                            subsists.

LEGAL FEES:                 CIBC's  costs,  including  legal  and  the  cost  to
                            prepare any environmental assessments, in connection
                            with the  preparation,  establishment,  operation or
                            enforcement of this Financing Commitment,  including
                            the Security, are for the account of the Borrower.

SECURITY:                   The  Borrower  will  provide  to  CIBC  and  PLC and
                            maintain   the   following   as  security   for  all
                            obligations  of  the  Borrower  arising  under  this
                            Financing  Commitment,  including  any  liability or
                            exposure  of CIBC under the Sundry  Options and CIBC
                            and/or PLC under the Swap Facility;

                            *   all Security granted CIBC by the Borrower under
                                the  Existing  Facility  or any other  previous
                                facilities including,  without limitation,  the
                                financing  commitments  dated November 25, 1998
                                and October 8, 1999;

                            *   a First Supplemental Debenture in the amount of
                                $17,500,000  conveying a first floating  charge
                                (with  right to fix) over all the  present  and
                                after-acquired property of the Borrower;

                            *   Negative pledge from CEC Resources Ltd. and
                                undertaking to provide fixed charge security;

                            *   Negative pledge from Carbon Energy  Corporation
                                with  respect  to  not  pledging,   mortgaging,
                                charging  or  otherwise   creating  a  security
                                interest in the  Borrower's  shares without the
                                prior  written  consent  of  CIBC,  in its sole
                                discretion;

                            *   General  Security  Agreement  providing a first
                                priority  security  interest in all present and
                                after-acquired   personal   property   of   the
                                Borrower;

                            *   Officer's certificate certifying ownership of
                                properties and interests as evaluated by CIBC;

                            *   Standard CIBC agreement respecting hydrocarbons;

                            *   Standard CIBC agreement and documentation
                                relative to Sundry Options;

                            *   Standard CIBC overdraft lending agreement and;

                            *   Standard ISDA form agreement relative to swap
                                transactions, (when required);

                            *   Master Firm Gas  Purchase/Sale  Agreement  with
                                any  relating  documents as required by CIBC or
                                its counsel, (when required); and
<PAGE>

                            *   Acknowledgement of Security from Borrower to
                                PLC and CIBC

                            *   Any  and  all   other security or documents as
                                required by CIBC or its counsel.
                                (collectively the "Security").

                            In the event of any conflict  between this Financing
                            Commitment   and  the   Security,   this   Financing
                            Commitment shall govern.

OTHER COVENANT:             CEC  Resources  Ltd.  covenants not to provide any
---------------             financial  support by guarantee,  pledge of its
                            shares, granting of a security  interest or other
                            mortgage,  charge,  lien or encumbrance of any kind,
                            or otherwise to an  affiliate  (as such term is
                            defined in the Business  Corporations  Act (Alberta)
                            without the prior written consent of CIBC, in its
                            sole discretion.

UNDERTAKING:                Upon  request,  the Borrower  agrees to provide CIBC
                            with  such   additional   security  that  in  CIBC's
                            reasonable opinion is required to cover its or PLC's
                            contingent  exposure and all indebtedness  under the
                            Swap  Facility,  including  without  limitation,  an
                            acknowledgement  and  amending  agreement  and  such
                            other  documentation  as CIBC may request to confirm
                            that  the  Security  held by CIBC as at date  hereof
                            secures such contingent exposure and indebtedness to
                            PLC and to amend the Security accordingly.

CONDITIONS
PRECEDENT
TO FUNDING:                 CIBC's obligation to provide increased  Availments
-----------                 shall be subject to the following  conditions
                            precedent being met, unless waived in writing by
                            CIBC:

                            *    execution of the Financing Commitment;

                            *    the Security in form and substance satisfactory
                                 to CIBC;

                            *    the receipt by CIBC of a duly executed
                                 environmental certificate in CIBC's standard
                                 form;

                            *    no Event of Default shall have occurred nor any
                                 event  which,  after notice or lapse of time or
                                 both, would become an Event of Default; and

                            *    the appropriate notice of borrowing,  notice of
                                 rollover  or notice of  conversion  shall  have
                                 been  delivered in  accordance  with the notice
                                 provisions provided herein.

ADDITIONAL
CONDITION:                  In  addition  to the  conditions  set  forth  above,
                            CIBC's obligation to provide Availments,  other than
                            rollovers or conversions of a then maturing advance,
                            shall be  suspended  for as long as  there  exists a
                            Borrowing Base Shortfall.
<PAGE>

REPORTING
REQUIREMENTS:               The Borrower will provide to CIBC:
-------------

                            *    audited  financial  statements of Carbon Energy
                                 Corporation  within 120 days of the Borrower's
                                 fiscal year-end;

                            *    Carbon Energy Corporation's quarterly 10 Q
                                 filings;

                            *    unaudited  annual  financial  statements of the
                                 Borrower  within 120 days of the  Borrower's
                                 fiscal year-end;

                            *    unaudited quarterly financial statements within
                                 60 days of the end of the  first  three  fiscal
                                 quarters of each fiscal year;

                            *    an independently  prepared economic and reserve
                                 evaluation  report  covering the Borrower's oil
                                 and gas properties  along with annual cash flow
                                 projections  and  capital  expenditure  budgets
                                 within 90 days of the end of each fiscal year;

                            *    at the  request  of  CIBC,  production  revenue
                                 statements on a monthly basis within 60 days of
                                 each month end, such statements  indicating the
                                 gross oil and gas  production,  net production,
                                 total  revenues,  royalties and other  burdens,
                                 operating  expenses  and  net  revenues,  in  a
                                 format acceptable to CIBC;

                            *    compliance  certificate  substantially  in the
                                 form of Schedule B hereto within 60 days of the
                                 end of each fiscal quarter; and

                            *    such other  documentation  and  information  as
                                 CIBC  may  reasonably  request,  including  any
                                 internally    or     independently     prepared
                                 environmental   assessment   reports   in   the
                                 Borrower's possession.

DISPOSITION
LIMIT:                      In addition  to the  Borrower's  covenants  found in
                            Schedule A, the  Borrower  will not sell,  convey or
                            otherwise  dispose  of any of its  Proved  Producing
                            Reserves  or related  facilities,  other than in the
                            normal course of business and on arm's length terms,
                            provided   that,  if  cumulative   proceeds  of  all
                            dispositions  to be received by the Borrower  exceed
                            $500,000 in any calendar year, such proceeds will be
                            used   to    permanently    repay   the    Principal
                            Indebtedness,  unless  other  arrangements  are made
                            with CIBC.

CHANGE
OF CONTROL:                 The Borrower shall notify CIBC of a Change
                            of Control as soon as it becomes aware thereof,  and
                            CIBC may at its sole  discretion,  by written notice
                            to  the  Borrower,  terminate  the  Facility  upon a
                            Change of Control  occurring.  Such termination will
                            be effective on the 30th day following the giving of
                            the  notice  by CIBC  and  thereupon  all  Principal
                            Indebtedness,  interest, fees and all amounts due by
                            the Borrower to CIBC or PLC under the Facility  will
                            be due and payable.

INDEMNITY:                  The Borrower agrees to indemnify and hold CIBC and
----------                  its officers,  directors,  employees and agents
                            harmless against any and all  liabilities  and costs
                            associated  with or as a result of CIBC and PLC
                            entering  into and  performing  their  obligations
                            under  this  Financing  Commitment,   including  but
                            not  limited  to liabilities or costs  associated
                            with or as a result of (i) any  transaction financed
                            or to be financed in whole  or  part,  directly  or
                            indirectly,  by the  proceeds  of this  Facility; or
                            (ii)  any  breach  or non-compliance of any
                            legislation,  order,  directive or judgment by the
                            Borrower for the protection of the environment. This
                            indemnity  will survive the  repayment, cancellation
                            or termination of this Financing Commitment.
<PAGE>

NOTICES:                    Any notice or  communication  to be given  hereunder
                            and under the Security may be  effectively  given by
                            delivering the same at the addresses hereinafter set
                            forth  or by  telecopy  or by  sending  the  same by
                            prepaid  registered  mail  to the  parties  at  such
                            addresses.  Any  notice so mailed  will be deemed to
                            have been given upon  actual  receipt  thereof.  The
                            address of the parties are:

                            CEC Resources Ltd.
                            1750, 530 - 8th Avenue S.W.
                            Calgary, Alberta
                            T2P 3S8

                            Attention:        Robert R. Morrison
                                              President
                            Telecopy:         (403) 262-8167

                            Canadian Imperial Bank of Commerce
                            Oil and Gas Group
                            10th Floor Bankers Hall
                            855 - 2nd Street S.W.
                            Calgary, Alberta
                            T2P 2P2

                            Attention:        Vice President, Oil & Gas
                            Telecopy:         (403) 221-5779

                            Either party may from time to time notify the other,
                            in accordance  with the  provisions  hereof,  of any
                            change of address or  addressee,  which  thereafter,
                            until changed by like notice, will be the address of
                            such  party  for  all  purposes  of  this  Financing
                            Commitment and the Security.

GENERAL TERMS
AND CONDITIONS:             Schedule "A" contains general definitions,
---------------             covenants,  events of default,  terms and conditions
                            which form part of this Financing Commitment.

<PAGE>

PRIOR
INDEBTEDNESS:               All  amounts   owing  by  the  Borrower  as  at  the
                            effective  date  hereof  under any  other  financing
                            commitment  or  agreement  shall  be  deemed  to  be
                            amounts owing under this Facility and this Financing
                            Commitment as of the effective date hereof.

                            OUR  FINANCING  COMMITMENT  IS OPEN TO ACCEPTANCE BY
                            YOU ON OR PRIOR TO OCTOBER 20, 2000.

                            CANADIAN IMPERIAL BANK OF COMMERCE

                            Per:
                            Name:    R.M. MacDonald
                            Title:   Director, Corporate Lending

                            Per:
                            Name:    Scott Daniel

                            Title:   Manager, Commercial Banking

                            THE ABOVE TERMS AND CONDITIONS  AND THOSE  CONTAINED
                            IN  THE  ATTACHED  SCHEDULE  "A"  ARE  AGREED  TO BE
                            EFFECTIVE THE DAY OF OCTOBER, 2000.

                            CEC RESOURCES LTD.

                            Per:
                            Name:    Robert Morrison
                            Title:   President

                            Per:
                            Name:    Kevin D. Struzeski
                            Title:   TreasurerEXHIBIT 10.1

                      FIRST AMENDMENT TO LICENSE AGREEMENT

      This First Amendment to License Agreement ("First Amendment") is entered
into as of July 10, 2000, by and among Triangle Pharmaceuticals, Inc., a
for-profit Delaware corporation with principal offices located at 4 University
Place, 4611 University Drive, Durham, North Carolina 27707 ("COMPANY") and Emory
University, a not-for-profit Georgia corporation with offices at 1380 South
Oxford Road, N.E., Atlanta, Georgia 30322 and the University of Georgia Research
Foundation, Inc., a not-for-profit Georgia corporation with offices at 631 Boyd
Graduate Studies Building, Athens, Georgia 30602-7411 ("UGARF"; EMORY and UGARF
being collectively referred to as the "LICENSORS"), and amends certain terms of
that certain License Agreement, dated as of March 31, 1996 between LICENSORS and
COMPANY (the "Agreement").

                                    RECITALS:

      A. LICENSORS and COMPANY have previously entered into the Agreement,
pursuant to which LICENSORS have licensed certain patent rights and know-how to
COMPANY with respect to Licensed Compounds.

      B. LICENSORS and COMPANY desire to amend certain terms of the Agreement as
set forth in this First Amendment.

      NOW, THEREFORE, for good and valuable consideration, COMPANY and LICENSORS
hereby agree as follows:

            1. Definitions. All terms used in this First Amendment and not
      otherwise defined herein shall have the same meanings ascribed to them in
      the Agreement.

            2. Amendment. Section 1.8 of the Agreement is deleted and replaced
      as follows:

                  1.8 "Licensed Compounds" shall mean: (a)(beta)-D-Dioxolanyl
            purines of the formula

                                [GRAPHIC OMITTED]
<PAGE>

            wherein R is OH, Cl, NH^2, or H, and X is H, alkyl, acyl,
            monophosphate, diphosphate or triphosphate; (b) all 5(1) and N(6)
            acylated and alkylated derivatives thereof; (c) any salts, esters,
            racemic mixtures and purified enantiomers of any of the foregoing;
            and (d) any and all polymorphs, hydrates and solvates of any of the
            foregoing. Notwithstanding the scope of this definition, neither
            LICENSORS represent that it shall obtain valid patent claims to any
            such compositions and LICENSORS specifically disclaim any warranties
            or representations as to whether the Licensed Patents cover any ***.

            3. General Terms.

                  (a) Except as expressly amended hereby, the remaining terms of
            the Agreement shall remain in full force and effect.

                  (b) The Agreement, as amended by this First Amendment,
            constitutes the entire agreement between LICENSORS and COMPANY or
            regarding the subject matters contained therein and herein.

                  (c) In the event of any conflict between the provisions of the
            Agreement and this First Amendment, the provisions of this First
            Amendment shall govern and control.

                  (d) This First Amendment shall be governed by, and construed
            in accordance with, the laws of the State of Georgia without regard
            to its conflicts of laws principles.

                  (e) This First Amendment may be executed in any number of
            counterparts, each of which shall be deemed an original and all of
            which shall constitute one and the same instrument.

                  (f) If any provision of this First Amendment is for any reason
            held to be ineffective, unenforceable or illegal, such condition
            shall not affect the validity or enforceability of any of the
            remaining portions hereof; provided, further, that the parties shall
            negotiate in good faith to replace any ineffective, unenforceable or
            illegal provision with an effective replacement as soon as is
            practical.

                [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

--------
*** Portions of this page have been omitted pursuant to a request for
Confidential Treatment and filed separately with the Commission.
<PAGE>

      IN WITNESS WHEREOF, LICENSORS and COMPANY have each executed this First
Amendment through an authorized officer as of the date first written above.

                              EMORY UNIVERSITY

                              By: /s/ John L. Temple
                                  ------------------------------------
                                  John L. Temple

                              Its: Executive Vice President

                              UNIVERSITY OF GEORGIA RESEARCH
                              FOUNDATION, INC.

                              By: /s/ Joe L. Key
                                  ------------------------------------
                                  Joe L. Key

                              Its: Executive Vice President

                              TRIANGLE PHARMACEUTICALS, INC.

                              By: /s/ David W. Barry
                                  ------------------------------------
                                  David W. Barry

                              Its: Chairman and Chief Executive Officer

                       [SIGNATURE PAGE TO FIRST AMENDMENT]

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00017-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00017-of-00352.parquet"}]]