Document:

EX-10.15.(a)

 Exhibit 10.15(a) 

HORACE MANN SERVICE CORPORATION 
 EXECUTIVE CHANGE IN CONTROL PLAN 
 SCHEDULE A PARTICIPANTS

 Note: The effective date of entry shall be subject to Section 4.2(a). 

 

					
	 NAME OR TITLE
	 		  	EFFECTIVE DATE OF PARTICIPATION*
		
		 	TIER I PARTICIPANTS
	 President and CEO
	 		  	November 14, 2012
		
		 	 TIER II PARTICIPANTS

	EVP and CFO	 		  	**
	EVP and Chief Marketing Officer	 		  	**
	EVP, Property and Casualty	 		  	**
	EVP, Annuity, Life, Group	 		  	February 15, 2012

  
 * Subject to acceptance within 30 days of effective
date of participation 
 ** Subject to Section 4.2(b) of the PlanEX-10.1

 Exhibit 10.1 
 CONFIDENTIAL 
 CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS
DOCUMENT PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION. 
  

 
 AMENDED AND RESTATED

 SUPPLY AGREEMENT 
 between 
 LAWRENCE LABORATORIES, an operating division of 

Swords Laboratories 
 and 
 CADENCE PHARMACEUTICALS, INC. 

effective as of February 22, 2013 

 
  

  
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 CONFIDENTIAL 
 TABLE OF CONTENTS 
  

							
	 Article
	 	 	  	Page	 
	1	 	Definitions	  	 	3	  
	2	 	Supply of Products	  	 	7	  
	3	 	Terms and Conditions of Purchase and Sale	  	 	9	  
	4	 	Regulatory Matters	  	 	17	  
	5	 	Confidentiality	  	 	18	  
	6	 	Indemnification	  	 	18	  
	7	 	Dispute Resolution	  	 	20	  
	8	 	Term; Termination	  	 	21	  
	9	 	Miscellaneous	  	 	23	  

 EXHIBITS 

Exhibit A: Specifications 
 Exhibit B:
Supply Price 
 Exhibit C: Reconciliation Payment 

 AMENDED AND RESTATED 

SUPPLY AGREEMENT 
 This Amended and Restated Supply Agreement (the “Agreement”) is entered into and is effective as of February 22, 2013 (the “Effective Date”) by and among Lawrence
Laboratories, an operating division of Swords Laboratories, which is organized under the laws of Ireland with its registered office at Unit 12, Distribution Centre, Shannon Industrial Estate, Shannon, County Clare, Ireland (“LL”),
and Cadence Pharmaceuticals, Inc., a Delaware corporation having an address at 12481 High Bluff Drive, Suite 200, San Diego, California 92130 (“Cadence”). LL is also a member of the Bristol Myers Squibb Company
(“BMS”) group of companies. LL and Cadence are sometimes collectively referred to herein collectively as the “Parties” and each individually as a “Party.” 

RECITALS 

WHEREAS, Cadence holds certain license rights in intellectual property relating to the Product (as defined below) in the United States
and Canada pursuant to that certain IV APAP Agreement dated February, 2006, between BMS and Cadence (the “IV APAP Agreement”), which sublicenses to Cadence certain intellectual property rights with respect to the United States
and Canada under that certain License Agreement dated December 23, 2002 between SCR Pharmatop, a civil law partnership organized under the laws of France, having its head office’s address at 10, Square St. Florentin, 78150 Le Chesnay,
France, recorded with the Register of Commerce and Companies of Versailles under No. 407552702, and BMS (the “Pharmatop License Agreement”) and licenses to Cadence certain rights to use patents and know-how of BMS in the same
jurisdictions; 
 WHEREAS, LL has made arrangements for one of its Affiliates (as defined below) located in Italy to manufacture
the Product for supply to Cadence pursuant to this Agreement; 
 WHEREAS, LL or its Affiliate holds certain license rights in
intellectual property relating to the Product (as defined below) in Italy entitling LL or its Affiliate to use such intellectual property to manufacture the Product in Italy for supply to Cadence pursuant to this Agreement; 

WHEREAS, LL or its Affiliates have expertise in manufacturing the Product; 

WHEREAS, Cadence and LL entered into a Supply Agreement effective as of December 1, 2010 (the “Original Supply
Agreement”), with respect to the supply of the Product to Cadence by LL’s Affiliate’s facility in Italy; and 

WHEREAS, Cadence and LL now wish to amend and restate the terms of the Original Supply Agreement in its entirety in the manner set forth
herein under which LL’s Affiliate will continue to manufacture the Product for Cadence’s commercial distribution. 

  
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 AGREEMENT 
 THEREFORE, the Parties, intending to be legally bound, agree as follows: 
 ARTICLE
1 
 DEFINITIONS 
 1.1 Defined Terms. As used in this Agreement, the following terms shall have the following meanings: 
 “Affiliate” of a Party means any corporation, firm, partnership or other entity that directly or indirectly Controls, is Controlled by or is under common Control with such Party.

 “Agreement” has the meaning set forth in the Introductory Paragraph. 

“Applicable Law” means any applicable federal, state, local or foreign statute, law, ordinance, rule or
regulation, judicial order or industry standard imposed by regulation or law, including without limitation the laws of, and regulations promulgated under, the FDCA or the Canadian equivalent of the FDCA. 

“Base Price” has the meaning set forth in Section 2.2(a). 

“BMS” has the meaning set forth in the Introductory Paragraph. 

“Business Day” means any day other than a Saturday, a Sunday or a United States Federal, EU, Irish or
Italian holiday. 
 “Cadence” has the meaning set forth in the Introductory Paragraph.

 “Cadence Party” has the meaning set forth in Section 6.1. 

“cGMP” means all current good manufacturing practices under 21 C.F.R. 210, as amended from time to time,
or any successor regulation. 
 “Claim” means any claim (including without limitation, product
liability claims, strict liability or tort claims and intellectual property infringement claims), action, suit, governmental investigation or other proceedings made or brought by or on behalf of a Third Party against any Cadence Party or any LL
Party, as the case may be, including without limitation enforcement actions by the FDA or other applicable Drug Regulatory Authorities and claims for infringement of intellectual property and for bodily injury, death or property damage. 

“Confidential Information” has the meaning set forth in the IV APAP Agreement. 

  
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 “Contract Year” will mean the twelve-month period beginning
on January 1, 2013, and each successive twelve-month period thereafter for the duration of this Agreement. 

“Control” means (a) with respect to Technology or technical information, the possession by a Party
of the ability to grant a license or sublicense of such Technology or technical information as provided herein without violating the terms of, or requiring a consent under, any agreement or arrangement between such Party and any Third Party and
(b) when used with respect to any Person means the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract, or otherwise. “Controlled”
and “Controlling” shall have correlative meanings. 
 “Demand” has the meaning
set forth in Section 7.2. 
 “Dispute” has the meaning set forth in Section 7.1.

 “Dollar” or “$” means United States dollars, the lawful currency of the
United States. 
 “Drug Regulatory Authority” means any governmental authority or
instrumentality with responsibility for granting any licenses, approvals, authorizations (e.g., the NDA) or granting pricing and/or reimbursement approvals necessary for the marketing and sale of pharmaceutical products in any regulatory
jurisdiction. 
 “Effective Date” has the meaning set forth in the Introductory Paragraph.

 “EMA” means the European Medicines Agency, or any successor agency. 

“Line Upgrade” has the meaning set forth in Section 2.1(d). 

“Facility” has the meaning set forth in Section 3.9. 

“FDA” means the United States Food and Drug Administration or any successor agency. 

“FDCA” means the Federal Food, Drug & Cosmetics Act, 21 U.S.C. 321 et seq., any amendments or
supplements thereto, or any regulations promulgated or adopted thereunder. 
 “Firm Order” has
the meaning set forth in Section 3.2(a). 
 “Force Majeure” means any circumstances that
are not within the reasonable control of the Person affected thereby, including without limitation an act of God, terrorist attack, war, insurrection, riot, strike or labor dispute, shortage of materials, fire, explosion, flood, government
requisition or allocation, breakdown of or damage to plant, equipment or facilities (to the extent that, in the event of a breakdown only, such plant, equipment or facilities were reasonably maintained), mandated requisition or allocation,

  
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interruption or delay in transportation, fuel supplies or electrical power, embargo, boycott, order or act of civil or military authority. 

“Forecast” has the meaning set forth in Section 3.1. 

“Implementation Date” means, with respect to each Line Upgrade, the date on which LL notifies Cadence
that the installation, testing, qualification and validation of such Line Upgrade has been completed, and the FDA has issued any Regulatory Approvals related to such Line Upgrade. 

“Incoterms” means the year 2010 edition of the official International Chamber of Commerce’s rules
for the interpretation of trade terms or any successor set of rules, guidelines or terms developed thereunder. 

“Indemnified Party” has the meaning set forth in Section 6.3. 

“Indemnifying Party” has the meaning set forth in Section 6.3. 

“IV APAP Agreement” has the meaning set forth in the Recitals. 

“Line Upgrade” has the meaning set forth in Section 2.1(c). 

“LL” has the meaning set forth in the Introductory Paragraph. 

“LL Party” has the meaning set forth in Section 6.2. 

“Losses” means, collectively, any and all liabilities, damages, reduction in value, costs, expenses,
including reasonable fees and disbursements of counsel and any consultants or experts and expenses of investigation, obligations, liens, assessments, court costs, arbitration or mediation fees, judgments, fines and penalties imposed upon or incurred
by an Indemnified Party (including, until such time as the Indemnifying Party assumes control of a given Claim, reasonable attorneys’ fees and costs of litigation pertaining to such Claim). 

“Materials” has the meaning set forth in Section 2.5(a). 

“Minimum Purchase Requirement” has the meaning set forth in Exhibit C. 

“NDA” means a new drug application or an abbreviated new drug application, including any amendments or
supplements thereto, filed by Cadence with the FDA pursuant to the FDCA, or any comparable filing with any Drug Regulatory Authority in Canada, and includes any Common Technical Document for the Registration of Pharmaceuticals for Human Use filed
with the FDA or any other Drug Regulatory Authority in the Territory. 
 “Original Supply
Agreement” has the meaning set forth in the Introductory Paragraph. 

  
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 “Parties” has the meaning set forth in the Introductory
Paragraph. 
 “Party” has the meaning set forth in the Introductory Paragraph. 

“Person” means any individual, firm, corporation, partnership, limited liability company, trust, joint
venture, governmental authority or other entity. 
 “Pharmatop License Agreement” has the
meaning set forth in the Recitals. 
 “Product” means the sterile, non-pyrogenic formulation of
paracetamol (acetaminophen) intended for intravenous infusion with a concentration of 10 mg/ml in 100 ml vials as more particularly set forth in the Specifications. Product shall be packaged with twenty-four (24) vials per case. 

“Quality Agreement” means the Quality Agreement – Drug product entered into between Cadence, LL and
Bristol-Myers Squibb Srl, effective as of December 7, 2010. 
 “Reconciliation Payment” has
the meaning set forth in Section 2.3(b). 
 “Reconciliation Price” has the meaning set
forth in Exhibit C. 
 “Regulatory Approval” means with respect to the Product in any
regulatory jurisdiction in the Territory, approval from the applicable Drug Regulatory Authority sufficient to market and sell the Product in such jurisdiction. 
 “Specifications” means the specifications set forth on Exhibit A, as amended by the Parties pursuant to the terms of the Quality Agreement. 

“Supply Price” has the meaning set forth in Section 2.2. 

“Supply Term” means the period beginning on April 1, 2011, and terminating on December 31,
2018, unless extended by the mutual agreement of the Parties. 
 “Technology” means and includes
all inventions, discoveries, improvements, trade secrets, know-how, processes, procedures, research records, records of inventions, test information, formulae, drawings, specifications, instructions, techniques, data, market surveys and other
similar proprietary methods, materials or property, whether or not patentable, relating to the Product, including but not limited to (a) samples of, methods of production or use of, and structural and functional information pertaining to,
chemical compounds, proteins or other biological substances, (b) data, formulations, techniques and know-how, and (c) rights under patents, patent applications, and copyrights. 

“Territory” means the United States (including Puerto Rico and all U.S. possessions and territories) and
Canada. 
 “Third Party” means a Person who or which is neither a Party nor an Affiliate of a
Party. 

  
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 ARTICLE 2 
 SUPPLY OF PRODUCTS 
 2.1 Supply and Purchase. 

(a) During the Supply Term and upon the terms and conditions set forth in this Agreement, LL shall, or shall cause its Affiliates to,
manufacture, or cause the manufacture of, and supply to Cadence certain quantities of the Product ordered pursuant to Firm Orders hereunder, subject to variations permitted by Section 3.2(a). Cadence shall purchase from LL and its Affiliates
all of the Product ordered by Cadence pursuant to Firm Orders hereunder. LL shall have no obligation to accept any Firm Order that calls for the delivery of the Product following the end of the Supply Term. 

(b) Subject to and with the exception of any existing commitments by or requirements for Cadence to purchase certain quantities of the
Product from Baxter Healthcare Corporation or its affiliates, during the Supply Term Cadence shall purchase at least seventy five percent (75%) of its requirements for the Product from LL for each Contract Year. Notwithstanding the foregoing,
under no circumstances shall Cadence be obligated to purchase at least seventy five percent (75%) of its requirements for the Product for each Contract Year in the event that (i) LL has failed to supply the specified quantities of the
Product in accordance with the delivery schedules set forth in each Firm Order, (ii) LL has failed to implement all Line Upgrades requested by Cadence within the timeframes reasonably requested by Cadence, or (iii) Cadence reasonably
believes that LL cannot deliver any quantity of Product set forth in a Firm Order for any reason whatsoever, including without limitation due to Force Majeure. Further, subject to the provisions of this Section 2.1(b), nothing herein shall
limit or otherwise restrict Cadence’s right to purchase the Product during the Supply Term of this Agreement from one or more alternate suppliers in addition to Baxter Healthcare Corporation and LL. 

(c) The Product shall be in finished vials, labeled and packed in cases of 24 vials per case. 

(d) Manufacturing Capacity Review & Line Upgrades. Prior to the commencement of each calendar quarter during the Term,
Cadence and LL shall review the most recent Forecast to determine if the forecasted amounts exceed the Facility’s annualized manufacturing capacity limits for the Product. In such event, Cadence and LL shall promptly discuss a mutually
agreeable timetable by which LL and its Affiliate shall implement certain manufacturing line upgrades required to increase the capacity limits of the Facility, such as palletizers and automatic case packers (the “Line Upgrade(s)”),
in order to ensure that the Facility has sufficient capacity to manufacture the amounts included in such Forecast. LL shall use commercially reasonable efforts to implement such Line Upgrades in accordance with the agreed-upon timetable. 

2.2 Supply Price 
 (a) The “Supply Price” for each vial of Product purchased during the Term shall be determined in accordance with Exhibit B to this Agreement. 

  
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 (b) Payment: The Supply Price and all other payments under this Agreement shall be in
U.S. Dollars. 
 2.3 Minimum Purchase Requirements. 

(a) Subject to Sections 8.2(a) and 8.2(b) of this Agreement, commencing with the Contract Year that begins on January 1, 2013,
during each Contract Year, Cadence shall purchase the applicable Minimum Purchase Requirement, as set forth in Exhibit C. 
 (b) In the event that the total number of Product vials ordered by Cadence from LL (based on Firm Orders placed) in a given Contract Year is less than the Minimum Purchase Requirement, Cadence shall pay
LL a reconciliation payment within thirty (30) days from the date of receipt of LL’s valid invoice for such payment, calculated in accordance with Exhibit C of this Agreement (the “Reconciliation Payment”).

 2.4 Miscellaneous Fees. Cadence shall pay LL for all additional services requested by Cadence in support of
commitments to FDA at a rate of $[***]/hour. Cadence shall also pay LL for any new validation batches that may be required at a price not to exceed $[***] per batch. In each case, LL shall provide Cadence with a written estimate of all such
miscellaneous fees at least [***] days in advance of the commencement of work (or as mutually agreed), and the Parties agree to work together to expeditiously resolve any disagreements as to the scope or costs of such services. No such services
shall be commenced until LL receives Cadence’s valid purchase order covering such services. In the event that the Parties are unable to reach agreement, the matter will be referred for resolution in accordance with Section 7.1 of this
Agreement. LL shall invoice Cadence for the foregoing fees in accordance with the principles set forth in Section 3.5. 

2.5 Additional Supply Provisions 
 (a) Materials. LL shall procure all materials required to produce the Product, including without limitation the active pharmaceutical ingredient (acetaminophen) (collectively, the
“Materials”) at such times, and in such amounts as required for LL to timely fulfill the Firm Orders. Both Parties agree to work together to reduce lead time for orders and deliveries of the Materials. LL shall obtain the Materials
only from suppliers listed in the NDA for the Product, and shall perform all testing of Materials required by the NDA or Quality Agreement. 
 (b) Label Copy. All label copy and changes thereto on the Product label shall be the responsibility of Cadence, and LL shall affix to the Product labels in the form most recently approved by
Cadence. 
  

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 (c) Stability Studies. LL shall perform, on an on-going basis, all stability studies
required by the Specifications, Applicable Laws, the NDA for the Product, and the Quality Agreement, at no additional cost to Cadence. 
 (d) Reference Standards. Unless available through the United States Pharmacopeia, Cadence shall provide, without charge to LL, analytical reference standards for the Product in quantities
reasonably required by LL to perform its obligations under this Agreement. 
 (e) Cadence Access to Facility. LL shall
use its commercially reasonable efforts to provide Cadence’s employee or contractor with reasonable access to the Facility at mutually agreeable times in order to facilitate such activities as batch record review and Product release. Any such
employee or contractor of Cadence shall comply fully with the Facility’s applicable safety, security and GMP procedures, 

ARTICLE 3 
 TERMS
AND CONDITIONS OF PURCHASE AND SALE 
 3.1 Forecasts. Prior to the first day of each calendar month during the Supply
Term, Cadence shall deliver to LL an updated forecast setting forth its requirements for the Product that Cadence expects to order for delivery during the [***] period beginning on the first day of such calendar month. Each such forecast is referred
to herein as, a “Forecast” and the Parties hereto acknowledge and agree that, except for the first [***] of each such Forecast, such Forecast shall not be binding on Cadence. 

3.2 Ordering. 
 (a) Cadence shall submit to LL a written irrevocable firm purchase order for all Product to be purchased by it not later than [***] prior to the first requested shipping date of such Product (each, a
“Firm Order”). Each such Firm Order shall include the quantity (full batches only; multiples of the minimum batch size) of the Product and the desired time and manner of shipment and the shipping destination, and shall be limited to
a single Product code (i.e., 24 vials per pack). Any Firm Order for any Product must be for a quantity equal to the minimum batch size for such Product as in effect from time to time or an integral multiple thereof. The minimum batch size in effect
as of the date of this Agreement is [***] vials of the Product ([***] cases of 24). LL shall be obligated to manufacture, supply and deliver the specified quantity of the Product in accordance with the delivery schedule set forth in each Firm Order,
however, the Parties agree that (i) the quantity of vials included in each Firm Order may not, without the prior agreement of LL, be greater than [***] of the quantity included in the most recent Forecast for such quarter provided to BMS, and
(ii) the actual number of vials 
  

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 successfully manufactured by LL for any batch of the Product may be within a range of plus or minus [***]
percent (+/-[***]%) of the minimum batch size or of the actual number of vials ordered by Cadence pursuant to a Firm Order. The number of vials of Product supplied by LL pursuant to a Firm Order may only vary from the amount actually ordered by
Cadence within such limits, and LL may ship to Cadence, and Cadence shall purchase, such greater or lesser number of vials in full satisfaction of such Firm Order, provided that Cadence shall only be required to purchase such number of vials
actually supplied to Cadence. LL shall provide to Cadence no less than [***] prior written notice of any change in the minimum batch size. Within [***] following receipt of each Firm Order, LL shall notify Cadence as to whether LL anticipates that
it will be unable to deliver the specified quantity of Product within the timeframe set forth in the Firm Order. In the event LL fails to so notify Cadence, the quantity and time specified in each such Firm Order shall be deemed accepted by LL. Firm
Orders may be amended by mutual agreement of the Parties, with no resulting penalty or cost to Cadence. LL shall exercise commercially reasonable efforts to comply with changes to Firm Orders that Cadence may request, but shall not be liable for its
inability to do so. 
 (b) No terms and conditions contained in any purchase order, acknowledgment, invoice, bill of lading,
acceptance or other preprinted form issued by either Party shall be effective to the extent they are inconsistent with or modify the terms and conditions contained herein. 
 3.3 Shipping Document. Each shipment of Product shall include a certificate of analysis and a packing slip that describes the Product, the date of manufacture, traceable lot or batch number(s),
quantities, shipment date and destination and such additional information as the Parties may agree in writing from time to time. 
 3.4 Delivery, Title, and Shipping. 
 (a) Delivery of Product shall be
[***] (Incoterms) the Facility (Anagni, Italy). LL or its Affiliates shall arrange for shipping of the Product, with a carrier designated by Cadence, in the manner customarily arranged for its own products from the point of manufacture to the
destination specified by Cadence. LL or its Affiliates shall arrange for Italian export clearances and loading at the port of departure. Expenses for special packaging, export or customs agents, shall be included in LL’s invoice and paid by
Cadence in accordance with Section 3.5. Cadence shall arrange for insurance from the Facility to the ultimate destination and import customs clearances at the destination country. Cadence shall be responsible for all loading charges, freight,
insurance, import customs clearances, export, special packaging, and other shipping expenses from the Facility to the ultimate destination. 
 (b) Title to the Product and risk of loss, delay or damage in transit for Product purchased by Cadence shall pass to Cadence when a shipment of the Product is placed at the disposal of Cadence’s
carrier at the Facility. Cadence shall cause its carrier to inspect all Product 
  

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 for physical damage prior to shipment, and Cadence shall promptly notify LL of any such physical damage.
Cadence shall bear the cost of all such pre-shipment inspection. LL and its Affiliates shall not have any responsibility for any loss or damage to any Product that occurs after LL or its export or customs agent places the Product at the disposal of
Cadence’s carrier, nor shall any loss or damage to any Product that occurs following such placement at the disposal of Cadence’s carrier obviate Cadence’s obligation to purchase and pay for such Product. Without limiting LL’s
right to recover the full invoiced amount for the Product and as partial security therefor, Cadence shall cause each shipment of Product to be insured for the full invoiced amount of each shipment. Cadence shall provide to LL proof, satisfactory to
LL, of such insurance. 
 The ultimate destination country of each shipment hereunder shall be in the Territory. 

(c) LL shall place the Product at the disposal of Cadence’s carrier at the Facility, appropriately labeled with a traceable lot or
batch number and packaged for shipping in the standard commercial packaging materials customarily used by LL not later than the shipping date requested by Cadence in its Firm Order. If Cadence requests a first shipping date that is less than [***]
after the delivery to LL of the applicable Firm Order, LL shall use reasonable commercial efforts to meet such earlier delivery date, but LL shall not be in breach of this Agreement for failing to meet such earlier delivery date. If LL or its
Affiliate is unable to place any shipment at the disposal of Cadence’s carrier by the date described in the first sentence of this paragraph, in addition to any other remedies available to Cadence pursuant to this Agreement or otherwise, LL
shall provide Cadence with updated delivery information (including estimated delivery date(s)) in writing on a weekly basis until such shipment has been made available to Cadence’s carrier. 

(d) LL shall, on Cadence’s behalf, make arrangements with a Cadence’s carrier to pick up each shipment of Product at the
Facility and to transport such shipment of Product to Cadence or its designee at the port of departure (maritime or air) specified by Cadence. Cadence shall have sole responsibility for the import of the Product into the Territory and for obtaining
all import and import-related customs permits and clearances; provided, however, that LL and its Affiliates shall promptly provide to Cadence all information and documentation reasonably requested by Cadence in order to obtain such permits
and clearances. 
 (e) In the event of any shortage of supply of Product due to Force Majeure, LL shall allocate its available
supply of Product between it and its Affiliates, its and its Affiliates’ other customers and Cadence on a pro rata basis based on the aggregate firm orders for the Product, which allocation shall be determined by LL in good faith. 

3.5 Invoicing and Payment. 
  

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 (a) LL shall invoice Cadence for the Product in Dollars at the time of shipment. Each
invoice shall include the invoice number, the Firm Order number, unit price and total price of the Product contained in the shipment. 
 (b) Cadence shall pay LL within [***] after the receipt of any undisputed invoice. All payments to be made hereunder to LL shall be made in Dollars by wire transfer of immediately available funds to such
bank account as may be designated by LL in writing from time to time, unless the Parties agree to settle such payments through other means. In the event Cadence disputes any invoice, Cadence shall pay any undisputed amount as and when due hereunder
and shall pay the additional amount, if any, owed with respect to such invoice not later than [***] following the resolution of such dispute. 
 (c) Any undisputed payment not made as and when due shall bear interest at the rate of [***] percent ([***]%) per annum, compounded daily, from the due date to the date of payment. In addition to but
without limiting the preceding sentence, LL shall have the right to suspend future shipments of Product to Cadence if LL does not receive payment within [***] after the date of any invoice, other than invoices subject to a bona fide dispute.
LL shall resume shipments of Product upon receiving such late payment and, if requested by LL, reasonable assurances as to payment of future invoices. 
 3.6 Inspection; Non-Conforming Product. 
 (a) Cadence shall promptly
inspect or cause to be inspected all shipments of Product hereunder. Within [***] after receipt by Cadence of any shipment of Product, Cadence may reject any lot or portion thereof which, at the time LL placed the Product at the disposal of
Cadence’s carrier, (i) failed to conform to the Specifications, (ii) was not manufactured in full conformance with Applicable Laws (including, without limitation, U.S. cGMPs) or the terms of this Agreement, or (iii) for which the
related batch record does not demonstrate conformance with the approved manufacturing process. Upon any such determination by Cadence, Cadence shall notify LL by sending LL notice of the lot or batch numbers of the rejected Product, together with an
indication of the specific basis for rejection and a sample of the rejected goods. Notwithstanding the foregoing, if the discovery of the non-conformity of any Product could not reasonably have been discovered until after such [***] period, Cadence
shall notify LL of such non-conformity promptly following the discovery thereof. Cadence shall not be entitled to reject any shipment or any portion thereof where it can be proven that the damage to the Product occurred following the time that LL
placed the Product at the disposal of Cadence’s carrier, and Cadence’s sole remedy shall be against the carrier or under any applicable insurance. LL shall have the right to examine and test any Product that Cadence claims to be
non-conforming. If it is determined that there is any such failure to conform to Specifications at the time that LL placed 
  

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the Product at the disposal of Cadence’s carrier, LL and Cadence shall cooperate to determine the cause of the non-conformity. 

(b) In the event that LL and Cadence do not resolve any issue where it is asserted that a batch of Product does not conform with the
Specifications within [***] after LL notifies Cadence that LL disagrees with Cadence’s belief as to the non-conformity of such Product at the time that LL placed the Product at the disposal of Cadence’s carrier, the Parties shall submit a
sample of the disputed Product to an independent laboratory, mutually selected by the Parties, for testing, and the results of such testing shall be binding upon the Parties, absent fraud or manifest error on the part of the independent laboratory.
The Party whose assertion as to the conformity or nonconformity of the Product in question is not supported by the results of the testing of the independent laboratory shall bear all costs and expenses of such testing. If the results of such testing
by such independent laboratory are inconclusive, then (i) all costs and expenses of such testing shall be borne by the Parties in equal shares and (ii) the Parties shall share equally the Supply Price of such Product and the freight,
insurance and other shipping expenses, fees, duties, taxes and levies incurred by the Parties in connection therewith, and Cadence shall pay to LL one-half of such Supply Price and other items within [***] after the receipt of such inconclusive
results; and (iii) LL shall promptly replace any such Product and deliver FCA, in accordance with Section 3.4, replacement conforming Product (even if such replacement entails shipping Product subsequent to the Supply Term), which shall be
purchased and paid for by Cadence in accordance with Article 2 and Section 3.5 of this Agreement. 
 (c) Cadence shall, as
requested by LL in its sole discretion: (i) return promptly to LL at LL’s expense all properly rejected Product or (ii) destroy such non-conforming Product in accordance with FDA guidelines or send such non-conforming Product to a
destruction facility of LL’s choice for destruction at LL’s expense. Cadence shall not be required to pay LL for any Product that has been properly rejected, and LL shall reimburse or credit Cadence for the freight, insurance and other
shipping expenses, fees, duties, taxes and levies for any shipment of Product that is properly rejected. LL shall promptly replace any properly rejected Product and supply to Cadence conforming Product (even if such replacement entails shipping
Product subsequent to the Supply Term). Cadence shall pay the Supply Price and all shipping costs (which shall include the cost of returning the Product to LL and reshipping such Product to Cadence or its designee) for any Product improperly
rejected. 
 3.7 Obsolescence Charge. To the extent that LL purchases inventories of materials, components or other
supplies pursuant to Cadence’s Forecast (based on vendor lead time), and such materials, components or other supplies become unusable as a result of a change to the Specifications requested by Cadence, [***] such inventories that are unique to
Cadence’s configuration of the Product and that were purchased but unused and cannot reasonably be used by LL for any other purpose. 
  

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 13 

 3.8 Quality Control. LL shall comply with all of the provisions and requirements of
the Quality Agreement in manufacturing, testing and supplying Product to Cadence. Any breach of the Quality Agreement shall be deemed a breach of this Agreement. In the event of any conflict between the terms of this Agreement and the Quality
Agreement with respect to quality assurance or quality control matters, the terms of the Quality Agreement shall control. 
 3.9
Change of Supplier or Facility. LL may upon [***] prior written notice to Cadence change the manufacturing facility used in the manufacturing of the Product (the “Facility”) to another facility, provided that any such change
in the manufacturing facility shall be expressly conditioned upon: (a) [***]; (b) [***]; (c) [***]; (d) [***]; and (e) [***]. 
 3.10 Recalls. Each Party shall notify the other by telephone within [***] after receiving any information, request or directive giving rise to a good faith belief that a recall of any Product
manufactured pursuant to this Agreement is or may be required under Applicable Law or is or may be otherwise necessary to avoid risk of injury or liability. Notwithstanding anything in this Agreement or the Quality Agreement to the contrary, Cadence
shall have sole discretion over whether and under what circumstances to require the recall of the Product in the Territory, unless a Drug Regulatory Authority in the Territory issues or requests a recall or takes similar action in connection with
such Product. 
 In the event that LL, in good faith, believes that a recall is required under Applicable Law or is otherwise
necessary to avoid risk of injury, it shall inform Cadence by providing written notice thereof to Cadence specifying, in reasonable detail, the nature and all relevant circumstances giving rise to LL’s belief that a recall is warranted, and
information regarding the affected Product. Within [***] following Cadence’s receipt of such written notification (or sooner if exigent circumstances exist or otherwise are required in order to comply with Applicable Law), the Parties shall
discuss the circumstances giving rise to such notification and the content of such notification, and, if so required, the timing and breadth of the recall, the strategies and notifications to be used by Cadence to effect the recall, and other
related issues. In the event that LL recommends to Cadence, in good faith, that a recall of a particular batch or batches of the Product should be conducted, and Cadence declines to recall such Product, LL shall be entitled to indemnification
pursuant to Section 6.2 of this Agreement. 
 LL and Cadence each shall maintain such traceability records as are
sufficient and as may be necessary to permit a recall, product withdrawal or field correction of any Product. Each Party shall provide full cooperation and assistance to the other Party in connection with any recall as may be reasonably requested by
the other Party. 
 (a) If a Product recall results from: (i) the failure of any Product, packaging or labeling supplied
hereunder to conform to the Specifications; (ii) the failure of any Product, packaging or labeling supplied hereunder to comply with Applicable Laws or the terms of this Agreement, including the Quality Agreement, at the time the Product was
delivered by LL to 
  

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 Cadence’s carrier; (iii) any negligent, grossly negligent or willful act or omission by LL or its
Affiliates, including without limitation the negligent or grossly negligent manufacture of the Product, LL shall: (x) credit to Cadence an amount equal to the total purchase price paid by Cadence to LL for the Product so recalled, plus
Cadence’s actual cost for direct material and direct labor furnished by Cadence or its contracting parties in connection with the manufacture of the recalled Product, (y) reimburse Cadence for all expenses associated with the conduct of
the recall action (e.g. advertising, mailing, administration, travel, etc.), and (z) indemnify and hold Cadence harmless from and against any and all damages, costs or charges, lawsuits or expenses associated with or resulting from any such
recall, including reasonable legal fees and disbursements. 
 (b) If a Product recall results from: (i) improper handling,
shipping or storage of the Product after delivery by LL to Cadence’s designated carrier, (ii) the inadequate or misleading nature of any text appearing on the packaging or labeling of the Product in compliance with the Specifications;
(iii) any negligent, grossly negligent or willful act or omission by Cadence, or (iv) due to circumstances other than those described in Section 3.10(a), above, then LL shall have no liability with respect to the recall and Cadence
shall indemnify, defend and hold LL and each other LL Indemnitee from any and all Losses suffered by such LL Indemnitee arising or related to such recall. 
 The rights and remedies available to each Party under this Section 3.10 are not exclusive and shall be in addition to all other right and remedies available to such Party at law and in equity.

 3.11 Product Complaints. Each Party shall notify the other Parties regarding Product complaints as agreed between the
Parties in the Quality Agreement. 
 3.12 Representations, Warranties and Covenants. 

(a) LL represents, warrants and covenants that the Product when delivered [***] (Incoterms) at the Facility in accordance with
Section 3.4 shall (i) conform to the Specifications; (ii) be manufactured, packaged, tested, stored, handled by it and its Affiliates in compliance with the Specifications, this Agreement, the Quality Agreement and all Applicable
Laws; (iii) be shipped to Cadence within [***] after the date of manufacture; and (iv) at the time of that LL places the Product at the disposal of Cadence’s carrier, not be adulterated or misbranded within the meaning of the FDCA.
Notwithstanding the foregoing, LL does not represent, warrant or covenant against any Product becoming adulterated or misbranded within the meaning of the FDCA or ceasing to conform to the Specifications as a result of an act or omission or damage
caused by Cadence or any Third Party (including any carrier of Cadence) after placement of the Product at the disposal of Cadence’s carrier pursuant to Section 3.4. LL represents, warrants and covenants that LL or its Affiliate shall
transfer to Cadence good and 
  

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 marketable title to the Product free from any and all liens, mortgages or encumbrances of any kind created
by LL and its Affiliates and its and their suppliers and creditors. 
 (b) LL represents, warrants and covenants that it and its
Affiliates hold and will continue to hold during the Supply Term sufficient rights in all manufacturing processes and Technology necessary for the manufacture and supply of the Product. 

(c) LL represents, warrants and covenants that as of the date hereof it has not received written notice of any pending or threatened
Claim that would interfere with LL’s performance under this Agreement or that materially and adversely affects the rights and interests of Cadence hereunder. 
 (d) LL represents and warrants that it is duly organized, validly existing and in good standing under the laws of Ireland, and that it has not been debarred and is not subject to debarment and that it
will not use in any capacity, in connection with the services to be performed under this Agreement, any person who has been debarred pursuant to Section 306 of the FDCA, or who is the subject of a conviction described in such section. LL agrees
to inform Cadence in writing immediately if it or any person who is performing services hereunder is debarred or is the subject of a conviction described in Section 306, or if any action, suit, claim, investigation or legal or administrative
proceeding is pending or, to the best of LL’s knowledge, is threatened, relating to the debarment or conviction of LL or any person performing services hereunder. 
 (e) Each Party represents, warrants and covenants that the execution and delivery of this Agreement and the performance of its obligations hereunder: (i) has been authorized to enter into this
Agreement by all necessary corporate action on the part of it and its shareholders, (ii) does not conflict with or violate any requirement of Applicable Law or any of its charter documents and (iii) does not conflict with, violate or
breach or constitute a default or require any consent (which has not been obtained) under, any contractual obligation, license or court or administrative order by which it is bound. 

(f) EXCEPT AS EXPRESSLY PROVIDED IN THISAGREEMENT, NEITHER LL NOR ANY OF ITS AFFILIATES MAKES ANY REPRESENTATION OR WARRANTY OF ANY KIND,
EXPRESS OR IMPLIED, WRITTEN OR ORAL, STATUTORY OR OTHERWISE WITH RESPECT TO THE PRODUCTS (WHETHER USED ALONE OR IN COMBINATION WITH OTHER SUBSTANCES) OR ANY MANUFACTURING PROCESS USED TO MANUFACTURE ANY PRODUCTS, INCLUDING WITHOUT LIMITATION
(i) ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE; (ii) ANY IMPLIED WARRANTIES ARISING FROM COURSE OF PERFORMANCE, COURSE OF DEALING OR USAGE IN THE TRADE; (iii) ANY WARRANTIES OF DESIGN OR DESCRIPTION
OR ANY WARRANTY OTHERWISE CREATED BY ANY AFFIRMATION OF FACT OR PROMISE OR SAMPLE OR MODEL; (iv) AND ALL SUCH REPRESENTATIONS AND WARRANTIES WHETHER IN CONTRACT, WARRANTY, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE, ARE HEREBY DISCLAIMED.

  
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 3.13 Force Majeure. No Party shall be considered to be in breach of, nor shall any
Party be liable for any failure to perform its obligations under, this Agreement (other than obligations to make payments of money) by reason of Force Majeure. A Party affected by Force Majeure shall give the other Party prompt notice of any
interruption of performance on account of Force Majeure, and of the resumption of such performance, and shall keep the other Party informed on a current basis as to the steps being taken to remove, and the anticipated time of removal of, the
circumstances resulting in such Force Majeure. The time for performance of any obligation hereunder that is affected by Force Majeure shall be extended by the actual time of delay caused by such Force Majeure, provided that the Party affected by
such Force Majeure uses commercially reasonable efforts to mitigate any such delay. Notwithstanding the foregoing, nothing in this Section 3.13 shall excuse or suspend the obligation to make any payment due under this Agreement in the manner
and at the time provided herein. 
 ARTICLE 4 
 REGULATORY MATTERS 
 4.1 Record Retention. Any books and records relating
to the receipt, manufacture, storage, handling or testing of any Product shall be maintained under this Agreement by a Party or its Affiliates in accordance with Applicable Law. 

4.2 Regulatory Matters. 
 (a) At all times during the Term, LL shall maintain the production facility, equipment and processes (including, without limitation, the process used in producing the Product and in performing LL’s
other obligations under this Agreement) in compliance with this Agreement, the Quality Agreement and all Applicable Laws (including, without limitation, cGMP, the FDA and, to the extent applicable, the EMA guidelines, employment and labor law
requirements, electrical, fire and safety at work codes and regulations and guidelines issued by any applicable Drug Regulatory Authorities in the Territory). LL shall make available for inspection, upon the request of Cadence, all documentation
relating to such compliance. 
 (b) LL shall permit representatives of Cadence to conduct inspections from time to time at all
Facilities utilized by LL and its Affiliates hereunder to manufacture the Product, as agreed between the Parties in the Quality Agreement. 
 (c) If either Party is notified that the Product manufactured at the Facility or the Facility will be subject to an inspection by FDA or any other Drug Regulatory Authority, such Party shall as soon as
possible notify the other Party by telephone and e-mail of its receipt of such notification. LL shall provide Cadence copies of all Drug Regulatory Authority-issued inspection observation reports (including, without limitation, Form 483s and
equivalent forms from other Drug Regulatory Authorities) and correspondence, purged only of confidential information that is unrelated to the Product. LL shall permit Cadence’s quality assurance representative to be present at the Facility
during any such inspection by FDA or any other Drug Regulatory Authority that relates to the Product or LL’s performance under this Agreement, provided, however, that Cadence shall only have access to or communicate with the inspectors

  
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during the facility inspection as permitted under the Quality Agreement. LL will also notify Cadence as soon as possible of LL’s receipt of any other Form 483’s or warning letters or
any other significant regulatory action which LL’s quality assurance group determines could impact the regulatory status of the Product. LL and Cadence will cooperate in resolving any concerns with any Drug Regulatory Authority, and Cadence may
review LL’s responses to any such reports and communications. LL will in its reasonable discretion incorporate into such responses any comments received from Cadence. LL will also inform Cadence of any action taken by any Drug Regulatory
Authority against LL or any of its officers or employees which may be reasonably expected to adversely affect the Product or LL’s ability to supply the Product hereunder within [***]. 

(d) LL hereby grants Cadence the right to reference any drug master file regarding the Product or similar regulatory filing in the
Territory that may now exist, or that may exist at any time during the Supply Term or any extension thereof, in any and all regulatory or other filings made by or on behalf of Cadence, its Affiliates or sublicensees. Upon the request of Cadence, LL
shall provide Cadence with a letter evidencing such right of reference. 
 ARTICLE 5 

CONFIDENTIALITY 

5.1 Confidentiality. Any Confidential Information of the Parties exchanged hereunder shall be governed by, and shall be maintained
in confidence pursuant to, the confidentiality provisions set forth in Section 5.2 and Section 5.3 of the IV APAP Agreement. 
 ARTICLE 6 
 INDEMNIFICATION 

6.1 By LL. LL shall indemnify, defend and hold harmless Cadence, its Affiliates and its and their employees, subcontractors,
agents, officers and directors (each, a “Cadence Party” ) from and against all Losses by a Cadence Party that result from or arise out of any Claim against a Cadence Party to the extent such Claims or Losses are alleged to be or are
in fact caused by, or are alleged to or in fact arise from or are based on any breach by LL or an LL Party of this Agreement or the Quality Agreement; provided, however, that LL shall not be obligated to indemnify a Cadence Party under
this Agreement for any Losses incurred by such Cadence Party to the extent attributable to (i) any breach of this Agreement or the Quality Agreement by Cadence or a Cadence Party or (ii) negligence, gross negligence or willful misconduct
on the part of Cadence or a Cadence Party. 
  

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 6.2 By Cadence. Cadence shall indemnify, defend and hold harmless LL, its Affiliates
and its and their employees, subcontractors, agents, officers and directors (each, an “LL Party”), from and against all Losses , liabilities, damages, fees (including, until such time as Cadence assumes control of a given Claim,
reasonable attorneys’ fees and costs of litigation pertaining to such Claim), and expenses paid or payable by an LL Party to a Third Party that result from or arise out of any Claim against an LL Party to the extent such Claim or any losses,
liabilities, damages or fees, cost and expenses in connection therewith is alleged to be or is in fact caused by, or is alleged to or in fact arises from or is based on (y) any handling, storage, consumption, administration, injection,
infusion, ingestion or other use or misuse of or exposure to the Product after the placement thereof at the disposal of Cadence’s carrier at the designated port of departure, or (z) Cadence’s decision not to recall the Product per
LL’s recommendation, as set forth in Section 3.10 of this Agreement; provided, however, that Cadence shall not be obligated to indemnify a LL Party under this Agreement for any Losses incurred by such LL Party to the extent
attributable to (i) any breach of this Agreement or the Quality Agreement by LL or any LL Party or (ii) negligence, gross negligence or willful misconduct on the part of LL or any LL Party, except to the extent that the Claim or any Losses
in connection therewith results from or arises out of (A) a failure of the Product to conform to the Specifications when placed at the disposal of Cadence’s carrier in accordance with Section 3.4; (B) any breach of this Agreement
or the Quality Agreement by LL or any LL Party; (C) any negligence, gross negligence or willful misconduct on the part of LL or any LL Party; or (D) any other matter for which LL is expressly obligated to indemnify Cadence pursuant to
Section 6.1. 
 6.3 Conditions to Indemnification. A Party seeking indemnification under this Article 6 (the
“Indemnified Party”) shall give prompt notice of the Claim to the other Party (the “Indemnifying Party”) and, provided that the Indemnifying Party is not contesting the indemnity obligation, shall permit the
Indemnifying Party to control and assume the defense of any litigation relating to such Claim and disposition of any such Claim unless the Indemnifying Party is also a party (or likely to be named a party) to the proceeding in which such Claim is
made and the Indemnified Party gives notice to the Indemnifying Party that it may have defenses to such Claim or proceeding that are in conflict with the interests of the Indemnifying Party, in which case the Indemnifying Party shall not be so
entitled to assume the defense of the case. If the Indemnifying Party does assume the defense of any Claim or proceeding, it (i) shall act diligently and in good faith with respect to all matters relating to the settlement or disposition of any
Claim as the settlement or disposition relates to Parties being indemnified under this Article 6, (ii) shall cause such defense to be conducted by counsel reasonably acceptable to the Indemnified Party, or (iii) shall not settle or
otherwise resolve any Claim without prior notice to the Indemnified Party and the consent of the Indemnified Party (which consent shall not be unreasonably withheld, conditioned or delayed) if such settlement involves anything other than the payment
of money by the Indemnifying Party. The Indemnified Party shall cooperate with the Indemnifying Party in its defense of any Claim for which the Indemnifying Party has assumed the defense in accordance with this Section 6.3, and shall have the
right (at its own expense) to be present in person or through counsel at all legal proceedings giving rise to the right of indemnification. 
 6.4 Limitation of Liability. IN NO EVENT SHALL EITHER PARTY (OR ANY OF ITS AFFILIATES OR SUBCONTRACTORS) BE LIABLE TO THE OTHER PARTY FOR, NOR SHALL ANY INDEMNIFIED PARTY HAVE THE RIGHT TO RECOVER,
ANY SPECIAL, INDIRECT, INCIDENTAL, PUNITIVE OR CONSEQUENTIAL DAMAGES 

  
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(INCLUDING LOST PROFITS OR DAMAGES FOR LOST OPPORTUNITIES), WHETHER IN CONTRACT, WARRANTY, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE (WHETHER IN ANY CLAIM FOR INDEMNIFICATION PURSUANT TO
THIS ARTICLE 6 OR OTHERWISE), ARISING (x) OUT OF THE MANUFACTURE, USE OR SALE OF ANY PRODUCT SOLD HEREUNDER OR (y) OUT OF ANY BREACH OF OR FAILURE TO PERFORM ANY OF THE PROVISIONS OF THIS AGREEMENT OR (z) ANY REPRESENTATION OR
WARRANTY CONTAINED IN OR MADE PURSUANT TO THIS AGREEMENT, EXCEPT THAT SUCH LIMITATION SHALL NOT APPLY TO PUNITIVE OR CONSEQUENTIAL DAMAGES PAID OR PAYABLE TO A THIRD PARTY BY AN INDEMNIFIED PARTY FOR WHICH THE INDEMNIFIED PARTY IS ENTITLED TO
INDEMNIFICATION HEREUNDER. 
 ARTICLE 7 
 DISPUTE RESOLUTION 
 7.1 Dispute Resolution. The Parties agree to attempt
to resolve any dispute, difference or question arising between the Parties or any of their Affiliates or Indemnified Parties in connection with this Agreement or the Quality Agreement, the formation, interpretation, construction thereof or the
rights, duties or liabilities of any Party or any of its Affiliates (a “Dispute”) through good faith negotiations between the Parties in accordance with this Section 7.1 The disputing party shall provide notice of the existence
and circumstances surrounding the Dispute to the other Party, in accordance with Section 9.1 of this Agreement. Within [***] after the receipt by the non-disputing Party of any such notice, the respective officers designated below or such other
officers as the Parties may designate in writing from time to time, shall meet in person to attempt to resolve the Dispute. The designated officers are as follows: 
  

			
	For LL:	  	John Nason
		  	Vice President External Manufacturing
		
	For Cadence:	  	Scott A. Byrd
		  	Chief Commercial Officer

 If such dispute is not solved by the end of a [***] period commencing upon the date on which the notice
was received by the non-disputing Party, the Parties shall refer the matter to binding arbitration, as set forth in Section 7.2, below. 
 7.2 Arbitration. Except as otherwise provided in this Agreement, any Dispute, not resolved through good faith negotiations as set forth in Section 7.1 shall be resolved by binding arbitration
in accordance with this Section 7.2. Any Party or any such Affiliate or Indemnified Party may require resolution of any such Dispute by arbitration hereunder by sending a written 

 

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 notice to the other Party demanding arbitration of the Dispute (the “Demand”). In that
event, the Dispute shall be finally resolved by arbitration in accordance with the United States Arbitration Act and the Commercial Arbitration Rules of the American Arbitration Association. The venue for the arbitration shall be New York, New York.
The arbitration shall be conducted in the English language before a panel of three (3) arbitrators. Each Party shall name one arbitrator, and the two so named shall name the third arbitrator, who shall act as chairman. If the two party
arbitrators cannot agree on a third arbitrator within [***] after the Demand, then at the request of either Party the President of the Association of the Bar of the City of New York shall appoint the third arbitrator. The arbitrators shall promptly
meet, fix the time, date and place of the hearing and notify the Parties. All documents, exhibits, testimony or other information that is not in the English language shall be translated into the English language at the expense of the Party
proffering the evidence requiring translation. The decision of the arbitrators may (depending on the equities of the case) include an award of legal fees, costs of arbitration and interest. The panel of arbitrators shall promptly transmit an
executed copy of its decision to the Parties. The decision of the arbitrators shall be final, binding and conclusive upon the Parties. Judgment on the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. Each
Party retains the right to seek from a court any interim or provisional relief that may be necessary to protect the rights or property of that Party as permitted by Section 9.3 hereof pending the establishment of the arbitrators’
determination of the merits of the controversy, and any such action shall not be deemed incompatible with this Agreement to arbitrate or a waiver of the right to arbitration. The obligations of the Parties under this Section are specifically
enforceable and shall survive any termination of this Agreement. Unless the decision of the arbitrators provides otherwise, the Parties shall bear their own costs in preparing for the arbitration and the costs of the arbitrators shall be equally
divided between the Parties. 
 ARTICLE 8 
 TERM; TERMINATION 
 8.1 Term; Termination. 

(a) This Agreement shall commence on the Effective Date and shall continue for the Supply Term unless earlier terminated pursuant to this
Section 8.1, or unless otherwise extended by written agreement of the Parties. Upon the Effective Date, the Parties agree that the Original Supply Agreement shall be superseded, in its entirety, by this Agreement. 

(b) This Agreement shall terminate upon the occurrence of any of the following events: 

(i) the written consent of each of LL and Cadence to terminate this Agreement; 

 

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 (ii) either Party’s notice of its intent to terminate this Agreement
for its convenience (without cause and without penalty) following twenty-four (24) months’ prior written notice; 
 (iii) the termination of the IV APAP Agreement; or 
 (iv) the
dissolution or termination of Cadence, other than in connection with or following an assignment of this Agreement in accordance with Section 9.7. 
 (c) Either Party may, by written notice to the other Party, terminate this Agreement upon the occurrence of any of the following events: 

(i) upon sixty (60) days’ prior written notice in the event of a material breach of this Agreement by the other
Party, which remains uncured by such other Party by the end of such sixty (60) day period; or 
 (ii)
effective upon written notice to the other Party, if the other Party becomes insolvent or admits in writing its inability to pay its debts as they become due, files a petition for bankruptcy, makes an assignment for the benefit of its creditors or
has a receiver, trustee or other court officer appointed for its properties or assets. 
 8.2 Consequences of
Termination. Termination of this Agreement pursuant to this Article 8 shall be without prejudice to any rights which shall have accrued to the benefit of any Party prior to such termination. Such termination shall not relieve any Party from
its obligations which are expressly indicated to survive the termination of this Agreement. All of the Parties’ rights and obligations under the immediately preceding sentence and under Sections 3.6, 3.7, 3.10, 3.11, 4.1, 4.2(c), 4.2(d)
and 8.2 and Articles 5, 6, 7 and 9 hereof shall survive such termination for the applicable period. 
 (a) In the event of
the termination of this Agreement by Cadence for its convenience under Section 8.1(b)(ii), or by BMS under Section 8.1(c)(i), Cadence will reimburse LL and its Affiliates for the cost of: (i) any Product ordered under any Firm Order
and received by Cadence; and (ii) any inventory of Materials purchased by LL in order to produce the Product in accordance with any forecasts and vendor lead times to the extent that (A) such Materials are specific to the Product, and
(B) LL and its Affiliate that holds such inventory are unable reasonably to utilize such inventory for other customers or for itself or any other LL Affiliate. Upon Cadence’s request, LL shall deliver any such inventory of Materials to
Cadence. Additionally, Cadence’s Minimum Purchase Requirement due in the Contract Year during which the effective date of any such termination occurs (i.e., twenty-four (24) months after the notice of termination under
Section 8.1(b)(ii)) shall be reduced proportionally, and Cadence shall not be obligated to purchase the Minimum Purchase Requirement for any subsequent Contract Year. 
 (b) In the event of the termination of this Agreement for any reason other than by Cadence for its convenience under Section 8.1(b)(ii) or by BMS under Section 8.1(c)(i), (i) Cadence shall
not be required to reimburse LL or its Affiliates for the cost of any inventory of Materials purchased by LL in order to produce the Product, and (ii) Cadence shall have no 

  
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obligation to purchase the Minimum Purchase Requirement for the Contract Year during which the effective date of any such termination occurs. 

ARTICLE 9 

MISCELLANEOUS 

9.1 Notices. All notices, consents, requests, demands and other communications required or permitted under this Agreement:
(a) shall be in writing in the English language; (b) shall be sent by messenger, a reliable express delivery service or facsimile (with a copy sent by one of the foregoing means), charges prepaid as applicable, to the appropriate
address(es) or number(s) set forth below; and (c) shall be deemed to have been given on the date of receipt by the addressee (or, if the date of receipt is not a Business Day, on the first Business Day after the date of receipt), as evidenced
by (i) a receipt executed by the addressee (or a responsible person in his or her office), the records of the Person delivering such communication or a notice to the effect that such addressee refused to claim or accept such communication, if
sent by messenger or express delivery service, or (ii) a receipt generated by the sender’s fax machine showing that such communication was sent to the appropriate number on a specified date, if sent by facsimile. All such communications
shall be sent to the following addresses or numbers, or to such other addresses or numbers as any Party may inform the others by giving five Business Days’ prior notice: 

 

			
	 If to Cadence:
  

Cadence Pharmaceuticals, Inc.
 12481 High Bluff
Drive, Suite 200
 San Diego, CA 92130

Attn: Chief Commercial Officer
 Fax No.:
[***]
  
	  	 With a copy to:
  

Cadence Pharmaceuticals, Inc.
 12481 High Bluff
Drive, Suite 200
 San Diego, CA 92130

Attn: Legal Department
 Fax No.: [***]

 

	 If to LL:
  
 Lawrence Laboratories
 Unit 12 Distribution Centre

Shannon Industrial Estate
 County
Clare
 Ireland
 Attn: General
Manager
 Fax No.: [***]
	  	 With a copy to:
  

Bristol-Myers Squibb Company
 1 Squibb
Drive
 New Brunswick, NJ
 Attn: Senior
Counsel Technical Operations
 Fax No.: [***]

  

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	 If to BMS:
  
 Bristol-Myers Squibb Company
 1 Squibb Drive

New Brunswick, NJ
 Attn: Director, Contract
Manufacturing
 Fax No.: [***]
	  	 With a copy to:
  

Bristol-Myers Squibb Company
 1 Squibb
Drive
 New Brunswick, NJ
 Attn:
Assistant General Counsel
 Fax No.: [***]

 9.2 Governing Law. This Agreement is a contract under the laws of the State of New York and for
all purposes shall be governed by, and construed and enforced in accordance with, the laws of said State, without giving effect to any conflict of law rules. 
 9.3 Equitable Relief. The Parties acknowledge and agree that each would be irreparably damaged in the event that any provision of this Agreement is not performed by the other in accordance with its
specific terms or is otherwise breached. Accordingly, it is agreed that each Party is entitled to seek an injunction or injunctions to prevent breaches of this Agreement by the other and shall have the right to seek to specifically enforce this
Agreement and the terms and provisions hereof against the other without the posting of any bond or other security, in addition to any other remedy to which such aggrieved Party may be entitled at law or in equity; provided, however,
that the powers of the arbitrators under Section 7.2 shall be limited to enforcing the obligations provided for in this Agreement as drafted. 
 9.4 Headings. All titles or captions contained in this Agreement are for convenience of reference only and shall not limit or affect in any way the meaning or interpretation of this Agreement.

 9.5 No Third Party Beneficiaries. This Agreement shall be binding upon, and inure solely to the benefit of, the
Parties and their permitted assigns, and nothing herein, express or implied, is intended to, or shall confer upon, any other Person any legal or equitable right, benefit or remedy of any nature whatsoever. 

9.6 Severability. If any term or other provision of this Agreement is held to be invalid, illegal or incapable of being enforced
by any Applicable Law or public policy, all other terms and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions contemplated hereby is not affected in any
manner materially adverse to any Party. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the Parties shall negotiate in good faith to modify this Agreement so as to effect the original
intent of the Parties as closely as possible in an acceptable manner in order that the transactions contemplated hereby are consummated as originally contemplated to the greatest extent possible. 

 

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 9.7 Assignment and Subcontracting. 

(a) Except as set forth below in this Section 9.7 neither this Agreement, nor any right, interest or obligation hereunder, may
be assigned, pledged or otherwise transferred by any Party, whether by operation of law or otherwise, without the prior consent of the other Party, except that either Party may assign any of its rights or delegate any of its obligations hereunder to
any of its Affiliates, provided, that (i) the assigning Party shall provide the other Party with written notice of any such assignment or delegation, (ii) the assigning Party shall unconditionally guarantee the full and timely
performance by its Affiliate of such Party’s obligations under this Agreement, which guarantee shall be a continuing guaranty and remain in full force and effect for so long as there shall remain any obligations (including, without limitation,
any indemnification obligations) or any representations or warranties of the assigning Party under this Agreement; and (iii) such Affiliate shall have first agreed in writing to be bound by the terms of this Agreement in connection with such
delegated obligations. Cadence acknowledges that LL will delegate the manufacturing of the Product to its Affiliate, Bristol-Myers Squibb S.R.L., in Italy and that delegation to such Affiliate shall not require any further notice to Cadence.

 (b) Either Party may assign or transfer all of its rights and obligations hereunder without the prior consent of the other
Party to a successor in interest by reason of merger, consolidation or sale of substantially all of the assets of the assigning Party (and so long as such assignment or transfer includes, without limitation, all Approvals, all manufacturing assets
relating to the IV APAP Agreement, and all rights and obligations under the IV APAP Agreement); provided, that such successor in interest shall have agreed prior to such assignment or transfer to be bound by the terms of this Agreement in a
writing provided to the other Party. 
 (c) LL may not subcontract any or all of its obligations under this Agreement to any
Third Party without the prior written consent of Cadence in its sole and absolute discretion. 
 (d) Not withstanding anything
to the contrary herein, any assignment, delegation or subcontracting by a Party of any of its rights or obligations under this Agreement shall not relieve such Party from any of its obligations hereunder. 

(e) Any assignment or transfer in violation of the foregoing shall be null and void and wholly invalid, the assignee or transferee in any
such assignment or transfer shall acquire no rights whatsoever, and the non-assigning non-transferring Party shall not be required to recognize, such assignment or transfer. 
 (f) Subject to the foregoing, this Agreement shall inure to the benefit of and be binding on the Parties’ successors and permitted assigns. 

9.8 Consents. Any consent or approval to any act or matter required under this Agreement shall be in writing and shall apply only
with respect to the particular act or matter to which such consent or approval is given, and shall not relieve any Party from the obligation to obtain the consent or approval, as applicable, wherever required under this Agreement to any other act or
matter. 

  
 25 

 9.9 Entire Agreement. This Agreement contains the entire agreement of the Parties
with respect to the subject matter of this Agreement and supersedes all prior written and oral agreements, and all contemporaneous oral agreements, relating to such subject matter. Notwithstanding the foregoing, nothing in this Agreement shall be
deemed to modify, amend or waive any provision of the IV APAP Agreement. 
 9.10 Exhibits. The Exhibits attached to this
Agreement are an integral part hereof and all references to this Agreement include such Exhibits. 
 9.11 Waivers and
Amendments. No modification of or amendment to this Agreement shall be valid unless in a writing signed by all Parties referring specifically to this Agreement and stating the Parties’ intention to modify or amend the same. Any waiver of
any term or condition of this Agreement shall be in a writing signed by the Party sought to be charged with such waiver referring specifically to the term or condition to be waived, and no such waiver shall be deemed to constitute the waiver of any
other breach of the same or of any other provision hereof. 
 9.12 No Partnership or Joint Venture. This Agreement is not
intended to create, and nothing contained herein shall be construed to create, an association, joint venture, trust or partnership, or to impose a trust or partnership covenant, obligation or liability on or with regard to the other Party. Each
Party shall be severally responsible for its own covenants, obligations and liabilities as herein provided. No Party shall be under the control of, or shall be deemed to control any other Party; no Party is the legal representative, agent, joint
venturer or employee of the other Party with respect to this Agreement for any purpose whatsoever; no Party shall have the right or power to bind the other Party; and no Party has the right or authority to assume or create any obligations of any
kind or to make any representation or warranty on behalf of any other Party, whether express or implied, or to bind any other Party in any respect whatsoever. The provisions of this Agreement are intended only for the regulation of relations between
the Parties. 
 9.13 Absence of Presumption. With regard to each and every term and condition of this Agreement and
any and all agreements and instruments subject to the terms hereof, the Parties hereto understand and agree that the same have or has been mutually negotiated, prepared and drafted, and if at any time the Parties hereto desire or are required to
interpret or construe any such term or condition or any agreement or instrument subject hereto, no consideration shall be given to the issue of which Party hereto actually prepared, drafted or requested any term or condition of this Agreement or any
agreement or instrument subject hereto. 
 9.14 Counterparts; Facsimile Execution. This Agreement may be executed in any
number of counterparts, and by each of the Parties on separate counterparts, each of which, when so executed, shall be deemed an original, but all of which shall constitute but one and the same instrument. Delivery of an executed counterpart of this
Agreement by facsimile shall be equally as effective as delivery of a manually executed counterpart of this Agreement. 
 9.15
Business Conduct and Ethics. BMS takes seriously its compliance and ethics responsibilities and seeks to do business only with third parties who share our high standards of ethical behavior. To that end, BMS has adopted Standards of Business
Conduct and Ethics for 

  
 26 

 
Third Parties (3P Standards). BMS encourages Cadence to comply with the elements of the 3P Standards that apply to Cadence. The 3P Standards are available at
http://www.bms.com/ourcompany/compliance_ethics/Pages/default.aspx. 
 [Remainder of page intentionally left blank.]

  
 27 

 SIGNATURE PAGE TO SUPPLY AGREEMENT 

IN WITNESS WHEREOF, the Parties have duly executed this Agreement as of the day and year first above written. 

 

			
	 LAWRENCE LABORATORIES, AN
 OPERATING DIVISION OF SWORDS
 LABORATORIES

		
	By:	 	 /s/ John Nason

		
	Name:	 	John Nason
		
	Title:	 	Vice president External Manufacturing
	
	CADENCE PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Theodore R. Schroeder

		
	Name:	 	Theodore R. Schroeder
		
	Title:	 	President and CEO

  
 28 

 EXHIBIT A 
 SPECIFICATIONS 
 Cadence Pharmaceuticals, Inc. 

Acetaminophen, Injection for Intravenous Use 
 [***] 
  

							
	[***]	  	[***]	  	[***]
	  	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	  	[***]	  	[***]
	[***]	  	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	[***]	  	[***]	  	[***]
	 [***] 
 [***]
	  		  	

 Confidential/Trade Secret/Proprietary Information of Cadence Pharmaceuticals, Inc. 

 

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been reinvested with respect to the omitted
portions. 

	
	[***]
	[***]
	[***]
	[***]

 Confidential/Trade Secret/Proprietary Information of Cadence Pharmaceuticals, Inc. 

 

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  
 2 

 EXHIBIT B 
 SUPPLY PRICE 
  

	(A)	Annual determination of Supply Price: During each Contract Year, LL will invoice Cadence at the applicable Supply Price shown in Table B, below, based upon the
aggregate quantity of Product that Cadence has specified that it intends to order during such Contract Year in the last annual Forecast delivered to LL prior to the commencement of such Contract Year. 

 

	(B)	Annual true-up payment: By [***], LL shall calculate the aggregate quantity of Product actually ordered by Cadence for delivery in the previous Contract Year,
and will compare such quantity to the quantities specified in the last annual Forecast delivered to LL prior to the commencement of such Contract Year. LL shall then promptly, as applicable, either (i) invoice Cadence, or (ii) repay to
Cadence or, at Cadence’s option, credit Cadence, the sum necessary to result in a position where the price actually paid by Cadence for Product ordered for delivery during the previous Contract Year is in accordance with the price structure set
forth in the table, below. 

  

															
	 TABLE B

	 Annual No.

Vials

Ordered (1)

(M)
	  	 From
Effective
Date until before
1st Line Upgrade
Implementation
Date
	  	From 1st Line
Upgrade
Implementation Date
until
before
2nd Line
Upgrade
Implementation Date	  	From 2nd Line
Upgrade
Implementation Date until before
3rd Line Upgrade
Implementation Date	  	After 3rd Line
Upgrade
Implementation Date
	  	  	Year 1	  	Subsequent
Years (2)	  	Year 1	  	Subsequent
Years (2)	  	Year 1	  	Subsequent
Years (2)
	 [***]
	  		  		  		  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  		  		  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  		  		  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  		  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]
	 [***]
	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]	  	[***]

  

	(1)	“Annual No. Vials Ordered” is determined based on number of vials included in the Firm Orders placed during the 12-month period following the most
recent applicable Line Upgrade Implementation Date. 

	(2)	The Supply Price for “Subsequent Years” applies to all years subsequent to the first year in which a Line Upgrade is implemented, unless an additional
Line Upgrade is implemented, in which case the Supply Price will be as set forth above for such Line Upgrade. 

  

			
	 - For Example Only -

	 Assumptions
	 	 Supply
Price

  

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  
 3 

			
	[***]	  	[***]
	[***]	  	[***]

  

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  
 4 

 EXHIBIT C 
 RECONCILIATION PAYMENT 
 Subject to Section 2.3(b), the amount of the
“Reconciliation Payment” for each Contract Year shall be equal to: 
 A times B, where A is the whole number
equal to the difference between the Minimum Purchase Requirement of vials applicable to each line upgrade, as set forth in Table C, below, and the total number of Product vials included in Cadence’s Firm Orders for the Contract Year; and

 B equals the applicable “Reconciliation Price”, as set forth in Table C, below, 

provided, however, that if the Implementation Date for a Line Upgrade occurs during a Contract Year, the Reconciliation Payment for such Contract
Year shall be prorated based on the date of the Line Upgrade Implementation Date. 
  

									
	 Table C

	 	  	From Effective Date until
before 1st Line
Implementation Date	 	From 1st Line 
Upgrade
Implementation Date until
before
2nd Line Upgrade
Implementation
Date	 	From 2nd Line 
Upgrade
Implementation Date until
before
3rd Line Upgrade
Implementation
Date	 	After 3rd Line 
Upgrade
Implementation Date
	Reconciliation Price	  	[***]	 	[***]	 	[***]	 	[***]
	Minimum Purchase Requirement	  	[***]	 	[***]	 	[***]	 	[***]

  

			
	 For Example Only

	 Assumptions
	 	 Reconciliation Payment

	[***]	 	[***]
	[***]	 	[***]
	[***]	 	[***]
	[***]	 	[***]

  

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  
 5 

			
	[***]	  	[***]
	[***]	  	[***]

  

	***	Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted
portions. 

  
 6

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