Document:

<PAGE>

       STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE--MODIFIED NET
                   AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION
                                   [LOGO]

1.     BASIC PROVISIONS ("BASIC PROVISIONS").

       1.1     PARTIES: This Lease ("LEASE"), dated for reference purposes
only, April 20, 2000, is made by and between SORRENTO WEST PARTNERS, L.P, a
California limited partnership ("LESSOR") and ELITRA PHARMACEUTICALS, INC., a
Delaware corporation ("LESSEE"), (collectively the "PARTIES," or individually
a "PARTY").

       1.2(a)  PREMISES: That certain portion of the Building, including all
improvements therein or to be provided by Lessor under the terms of this
Lease, commonly known by the street address of 11055 Flintkote Avenue, Suites
A, B, C and D, consisting of approximately 10,612 rentable square feet,
located in the City of San Diego, County of San Diego, State of California,
with zip code 92121, as outlined on Exhibit A attached hereto ("PREMISES").
The "BUILDING" is that certain building containing the Premises and generally
described as (describe briefly the nature of the Building): 11055 Flintkote
Avenue, a Portion of the Sorrento West Industrial Park ("Industrial Center").
In addition to Lessee's rights to use and occupy the Premises as hereinafter
specified, Lessee shall have non-exclusive rights to the Common Areas (as
defined in Paragraph 2.7 below) as hereinafter specified, but shall not have
any rights to the roof, exterior walls or utility raceways of the Building or
to any other buildings in the Industrial Center. The Premises, the Building,
the Common Areas, the land upon which they are located, along with all other
buildings and improvements thereon, are herein collectively referred to as
the "INDUSTRIAL CENTER." (Also see Paragraph 2.)

       1.2(b)  PARKING: Pro-rata share of unreserved vehicle parking spaces
("UNRESERVED PARKING SPACES"); and Zero (0) reserved vehicle parking spaces
("RESERVED PARKING SPACES"). (Also see Paragraph 2.6(a).)

       1.3     TERM: Three (3) years and Approximately six (6) months
("ORIGINAL TERM") commencing April 21, 2000 ("COMMENCEMENT DATE") and ending
September 30, 2003 ("EXPIRATION DATE"). (Also see Paragraph 3.)

       1.4     EARLY POSSESSION: N/A ("EARLY POSSESSION DATE"). (Also see
Paragraphs 3.2 and 3.3.)

       1.5     BASE RENT: $22,285.20 per month ("BASE RENT"), payable on the
First (1st) day of each month commencing on execution of Lease (Also see
Paragraph 4 and Addendum, Paragraph 50.)

/x/  If this box is checked, this Lease provides for the Base Rent to be
     adjusted per Addendum Paragraph 52, attached hereto.

       1.6(a)  BASE RENT PAID UPON EXECUTION: $22,285.20 as Base Rent for the
period from execution of Lease, to be applied to first Base Rent payable
hereunder.

       1.6(b)  LESSEE'S SHARE OF COMMON AREA OPERATING EXPENSES:
10,612/162,727 percent (6.52%) ("LESSEE'S SHARE") as determined by /x/
prorata square footage of the Premises as compared to the total square
footage of the Industrial Center or / / other criteria as described in
Addendum ___.

       1.7     SECURITY DEPOSIT: $133,711 ("SECURITY DEPOSIT") (Also see
Paragraph 5 and Addendum, Paragraph 53.)

       1.8     PERMITTED USE: Life science research and manufacturing, sales
and administration, general office, and other legal uses which are not
inconsistent with a life science research and development project, to the
extent permitted under existing and future zoning regulations ("PERMITTED
USE") (Also see Paragraph 6.)

       1.9     INSURING PARTY. Lessor is the "INSURING PARTY." (Also see
Paragraph 8.)

       1.10(a) REAL ESTATE BROKERS. The following real estate broker(s)
(collectively, the "BROKERS") and brokerage relationships exist in this
transaction and are consented to by the Parties (check applicable boxes):

/x/ CB Richard Ellis Commercial Real Estate represents Lessor exclusively
    ("LESSOR'S BROKER");
/x/ Irving Hughes Group represents Lessee exclusively ("LESSEE'S BROKER"); or
/ / ________________________ represents both Lessor and Lessee ("DUAL AGENCY").

       1.10(b) PAYMENT TO BROKERS. Upon the execution of this Lease by both
Parties, Lessor shall pay to said Broker(s) jointly, or in such separate
shares as they may mutually designate in writing, a fee as set forth in a
separate written agreement between Lessor and said Broker(s) (or in the event
there is no separate written agreement between Lessor and said Broker(s), the
sum of $ per separate Agreement) for brokerage services rendered by said
Broker(s) in connection with this transaction. (Also see Paragraph 15 and
Addendum, Paragraph 58.)

       1.11    GUARANTOR. The obligations of the Lessee under this Lease are
to be guaranteed by N/A ("GUARANTOR"). (Also see Paragraph 37.)

       1.12    ADDENDA AND EXHIBITS. Attached hereto is an Addendum or
Addenda consisting of Paragraphs 49 through 66, and Exhibits A through D, all
of which constitute a part of this Lease.

2.     PREMISES, PARKING AND COMMON AREAS.

       2.1     LETTING. Lessor hereby leases to Lessee, and Lessee hereby
leases from Lessor, the Premises, for the term, at the rental, and upon all
of the terms, covenants and conditions set forth in this Lease. Unless
otherwise provided herein, any statement of square footage set forth in this
Lease, or that may have been used in calculating rental and/or Common Area
Operating Expenses, is an approximation which Lessor and Lessee agree is
reasonable and the rental and Lessee's Share (as defined in Paragraph 1.6(b))
based thereon is not subject to revision whether or not the actual square
footage is more or less. Lessee's Share shall be subject to revision based
upon changes made pursuant to Paragraph 2.10 or based upon the ratio between
the rentable square footage of the Premises and the rentable square footage
of space in all buildings within the Industrial Center which utilize the
specific utility or service provided by Landlord.

       2.2     CONDITION. Lessor shall deliver the Premises to Lessee clean
and free of debris on the Commencement Date and warrants to Lessee that the
existing plumbing, electrical systems, fire sprinkler system, lighting, air
conditioning and heating systems, and loading doors, if any, in the Premises,
other than those constructed by Lessee, shall be in good operating condition
on the Commencement Date. If a non-compliance with said warranty exists as of
the Commencement Date, Lessor shall, except as otherwise provided in this
Lease, promptly after receipt of written notice from Lessee setting forth
with specificity the nature and extent of such non-compliance, rectify same
at Lessor's expense. If Lessee does not give Lessor written notice of a
non-compliance with this warranty within thirty (30) days after the
Commencement Date, correction of that non-compliance shall be the obligation
of Lessee at Lessee's sole cost and expense.

                                                                 INITIALS:  GH
                                                                           ----
                                                                            NC
                                                                           ----
                         MULTI-TENANT - MODIFIED NET

-C-1993 - AMERICAN INDUSTRIAL REAL          REVISED             FORM MTN-1-6/93E
          ESTATE ASSOCIATION

                               Page 1 of 13

<PAGE>

       2.3     COMPLIANCE WITH COVENANTS, RESTRICTIONS AND BUILDING CODE.
Lessor warrants, to Lessor's actual knowledge, that any improvements (other
than those constructed by Lessee or at Lessee's direction) on or in the
Premises which have been constructed or installed by Lessor or with Lessor's
consent or at Lessor's direction, but without regard to Lessee's intended use
of the Premises, shall comply with all applicable covenants or restrictions
of record and applicable building codes, regulations and ordinances in effect
on the Commencement Date. Lessor further warrants to Lessee that Lessor has
no knowledge of any claim having been made by any governmental agency that a
violation or violations of applicable building codes, regulations, or
ordinances exist with regard to the Premises as of the Commencement Date.
Said warranties shall not apply to any Alterations or Utility Installations
(defined in Paragraph 7.3(a)) made or to be made by Lessee. If the Premises
do not comply with said warranties, Lessor shall, except as otherwise
provided in this Lease, promptly after receipt of written notice from Lessee
given within three (3) months following the Commencement Date and setting
forth with specificity the nature and extent of such non-compliance, take such
action, at Lessor's expense, as may be reasonable or appropriate to rectify
the non-compliance. Lessor makes no warranty that the Permitted Use in
Paragraph 1.8 is permitted for the Premises under Applicable Laws (as defined
in Paragraph 2.4).

       2.4     ACCEPTANCE OF PREMISES. Lessee hereby acknowledges: (a) that
it has been advised by the Broker(s) to satisfy itself with respect to the
condition of the Premises (including, but not limited to, the electrical and
fire sprinkler systems, security, environmental aspects, flood zone
classification, seismic and earthquake requirements, and compliance with the
Americans with Disabilities Act and applicable zoning, municipal, county,
state and federal laws, ordinances and regulations, and any covenants or
restrictions of record (collectively, "APPLICABLE LAWS") and the present and
future suitability of the Premises for Lessee's intended use; (b) that Lessee
has made such investigation as it deems necessary with reference to such
matters, is satisfied with reference thereto, and assumes all responsibility
therefore as the same relate to Lessee's occupancy of the Premises and/or the
terms of this Lease; and (c) that neither Lessor, nor any of Lessor's agents,
has made any oral or written representations or warranties with respect to
said matters other than as set forth in this Lease. Lessee further
acknowledges that the Premises are located within the FEMA Flood Insurance
Rate Map Zone AE. Lessee further acknowledges that the subject Premises may
not be compliant with current state and/or federal requirements concerning the
Americans with Disabilities Act (ADA). Lessor shall have no obligation to
correct any ADA non-compliance or to incur any expense with respect thereto,
except to the extent of approved plans and specifications for the Tenant
improvements to the Premises provided by Lessor, pursuant to Addendum,
Paragraph 51.

       2.5     LESSEE AS PRIOR OWNER/OCCUPANT. The warranties made by Lessor
in this Paragraph 2 shall be of no force or effect if immediately prior to
the date set forth in Paragraph 1.1 Lessee was the owner or occupant of the
Premises. In such event, Lessee shall, at Lessee's sole cost and expense,
correct any non-compliance of the Premises with said warranties.

       2.6     VEHICLE PARKING. Lessee shall be entitled to use the number of
Unreserved Parking Spaces and Reserved Parking Spaces specified in Paragraph
1.2(b) on those portions of the Common Areas designated from time to time by
Lessor for parking.  Lessee shall not use more parking spaces than said number.
Said parking spaces shall be used for parking by vehicles no larger than
full-size passenger automobiles or pick-up trucks, herein called "PERMITTED
SIZE VEHICLES." Vehicles other than Permitted Size Vehicles shall be parked
and loaded or unloaded as directed by Lessor in the Rules and Regulations (as
defined in Paragraph 40) issued by Lessor. (Also see Paragraph 2.9.)

               (a)     Lessee shall not permit or allow any vehicles that
belong to or are controlled by Lessee or Lessee's employees, suppliers,
shippers, customers, contractors or invitees to be loaded, unloaded, or parked
in areas other than those designated by Lessor for such activities.

               (b)     If Lessee permits or allows any of the prohibited
activities described in this Paragraph 2.6, then Lessor shall have the right,
without notice, in addition to such other rights and remedies that it may
have, to remove or tow away the vehicle involved and charge the cost to
Lessee, which cost shall be immediately payable upon demand by Lessor.

               (c)     Lessor shall at the Commencement Date of this Lease
provide the parking facilities required by Applicable Law.

       2.7     COMMON AREAS - DEFINITION. The term "COMMON AREAS" is defined
as all areas and facilities outside the Premises and within the exterior
boundary line of the Industrial Center and interior utility raceways within
the Premises that are provided and designated by the Lessor from time to time
for the general nonexclusive use of Lessor, Lessee and other lessees of the
Industrial Center and their respective employees, suppliers, shippers,
customers, contractors and invitees, including parking areas, loading and
unloading areas, trash areas, roadways, sidewalks, walkways, parkways,
driveways and landscaped areas.

       2.8     COMMON AREAS - LESSEE'S RIGHTS. Lessor hereby grants to
Lessee, for the benefit of Lessee and its employees, suppliers, shippers,
contractors, customers and invitees, during the term of this Lease, the
non-exclusive right to use, in common with others entitled to such use, the
Common Areas as they exist from time to time, subject to any rights, powers,
and privileges reserved by Lessor under the terms hereof or under the terms
of any rules and regulations or restrictions governing the use of the
Industrial Center. Under no circumstances shall the right herein granted to
use the Common Areas be deemed to include the right to store any property,
temporarily or permanently, in the Common Areas. Any such storage shall be
permitted only by the prior written consent of Lessor or Lessor's designated
agent, which consent may be revoked at any time. In the event that any
unauthorized storage shall occur then Lessor shall have the right, without
notice, in addition to such other rights and remedies that it may have, to
remove the property and charge the cost to Lessee, which cost shall be
immediately payable upon demand by Lessor.

       2.9     COMMON AREAS - RULES AND REGULATIONS. Lessor or such other
person(s) as Lessor may appoint shall have the exclusive control and
management of the Common Areas and shall have the right, from time to time,
to establish, modify, amend and enforce reasonable Rules and Regulations with
respect thereto in accordance with Paragraph 40. Lessee agrees to abide by
and conform to all such Rules and Regulations, and to cause its employees,
suppliers, shippers, customers, contractors and invitees to so abide and
conform. Lessor shall not be responsible to Lessee for the non-compliance
with said rules and regulations by other lessees of the Industrial Center.

       2.10    COMMON AREAS - CHANGES. Lessor shall have the right, in
Lessor's sole discretion, from time to time:

               (a)     To make changes to the Common Areas, including,
without limitation, changes in the location, size, shape and number of
driveways, entrances, parking spaces, parking areas, loading and unloading
areas, ingress, egress, direction of traffic, landscaped areas, walkways and
utility raceways;

               (b)     To close temporarily any of the Common Areas for
maintenance purposes so long as reasonable access to the Premises remains
available;

               (c)     To designate other land outside the boundaries of the
Industrial Center to be a part of the Common Areas to the extent such land
benefits the occupants of the Industrial Center;

               (d)     To add additional buildings and improvements to the
Common Areas;

               (e)     To use the Common Areas while engaged in making
additional improvements, repairs or alterations to the Industrial Center, or
any portion thereof; and

               (f)     To do and perform such other acts and make such other
changes in, to or with respect to the Common Areas and Industrial Center as
Lessor may, in the exercise of sound business judgment, deem to be
appropriate.

3.     TERM.

       3.1     TERM. The Commencement Date, Expiration Date and Original Term
of this Lease are as specified in Paragraph 1.3.

       3.2     EARLY POSSESSION. If an Early Possession Date is specified in
Paragraph 1.4 and if Lessee totally or partially occupies the Premises after
the Early Possession Date but prior to the Commencement Date, the obligation
to pay Base Rent shall be abated for the period of such early occupancy. All
other terms of this Lease, however, (including, but not limited to, the
obligations to pay Lessee's Share of Common Area Operating Expenses and to
carry the insurance required by Paragraph 8) shall be in effect during such
period. Any such early possession shall not affect nor advance the Expiration
Date of the Original Term.

       3.3     DELAY IN POSSESSION. If for any reason Lessor cannot deliver
possession of the Premises to Lessee by the Early Possession Date, if one is
specified in Paragraph 1.4, or if no Early Possession Date is specified, by
the Commencement Date, Lessor shall not be subject to any liability therefor,
nor shall such failure affect the validity of this Lease, or the obligations
of Lessee hereunder, or extend the term hereof, but in such case, Lessee
shall not, except as otherwise provided herein, be obligated to pay rent or
perform any other obligation of Lessee under the terms of this Lease until
Lessor delivers possession of the Premises to Lessee.

                                                                 INITIALS:  GH
                                                                           ----
                                                                            NC
                                                                           ----
                               Page 2 of 13

<PAGE>

4.     RENT.

       4.1     BASE RENT. Lessee shall pay Base Rent and other rent or
charges, as the same may be adjusted from time to time, to Lessor in lawful
money of the United States, without offset or deduction, on or before the day
on which it is due under the terms of this Lease. Base Rent and all other
rent and charges for any period during the term hereof which is for less than
one full month shall be prorated based upon the actual number of days of the
month involved. Payment of Base Rent and other charges shall be made to
Lessor at its address stated herein or to such other persons or at such other
addresses as Lessor may from time to time designate in writing to Lessee.

       4.2     COMMON AREA OPERATING EXPENSES. Lessee shall pay to Lessor
during the term hereof, in addition to the Base Rent, Lessee's Share (as
specified in Paragraph 1.6(b)) of all Common Area Operating Expenses, as
hereinafter defined, during each calendar year of the term of this Lease, in
accordance with the following provisions: (Also see Addendum, Paragraph 55.)

               (a)     "COMMON AREA OPERATING EXPENSES" are defined, for
purposes of this Lease, as all costs incurred by Lessor relating to the
ownership and operation of the Industrial Center, including, but not limited
to, the following:

                       (i)     The operation, repair and maintenance, in
neat, clean, good order and condition, of the following:

                               (aa)    The Common Areas, including parking
areas, loading and unloading areas, trash areas, roadways, sidewalks,
walkways, parkways, driveways, landscaped areas, striping, bumpers,
irrigation systems, Common Area lighting facilities, fences and gates,
and roof.

                               (bb)    Exterior signs and any tenant
directories.

                               (cc)    Fire detection and sprinkler systems.

                       (ii)    The cost of water, gas, electricity and
telephone to service the Common Areas.

                       (iii)   Trash disposal, property management and
security services and the costs of any environmental inspections.

                       (iv)    Reserves set aside for maintenance and repair
of Common Areas.

                       (v)     Real Property Taxes (as defined in Paragraph
10.2) to be paid by Lessor for the Building and the Common Areas under
Paragraph 10 hereof.

                       (vi)    The cost of the premiums for the insurance
policies maintained by Lessor under Paragraph 8 hereof or other insurance
procured by Lessor in its commercially reasonable discretion.

                       (vii)   Any deductible portion of an insured loss
concerning the Building or the Common Areas.

                       (viii)  Any other services to be provided by Lessor
that are stated elsewhere in this Lease to be a Common Area Operating
Expense.

               (b)     Any Common Area Operating Expenses and Real Property
Taxes that are specifically attributable to the Building or to any other
building in the Industrial Center or to the operation, repair and maintenance
thereof, shall be allocated entirely to the Building or to such other
building. However, any Common Area Operating Expenses and Real Property Taxes
that are not specifically attributable to the Building or to any other
building or to the operation, repair and maintenance thereof, shall be
equitably allocated by Lessor to all buildings in the Industrial Center.

               (c)     The inclusion of the improvements, facilities and
services set forth in Subparagraph 4.2(a) shall not be deemed to impose an
obligation upon Lessor to either have said improvements or facilities or to
provide those services unless the Industrial Center already has the same,
Lessor already provides the services, or Lessor has agreed elsewhere in this
Lease to provide the same or some of them.

               (d)     Lessee's Share of Common Area Operating Expenses shall
be payable by Lessee within ten (10) days after a reasonably detailed
statement of actual expenses is presented to Lessee by Lessor. At Lessor's
option, however, an amount may be estimated by Lessor from time to time of
Lessee's Share of annual Common Area Operating Expenses and the same shall be
payable monthly or quarterly, as Lessor shall designate, during each 12-month
period of the Lease term, on the same day as the Base Rent is due hereunder.
Lessor shall deliver to Lessee within ninety (90) days after the expiration
of each calendar year a reasonably detailed statement showing Lessee's Share
of the actual Common Area Operating Expenses incurred during the preceding
year. If Lessee's payments under this Paragraph 4.2(d) during said preceding
year exceed Lessee's Share as indicated on said statement, Lessee shall be
credited the amount of such overpayment against Lessee's Share of Common Area
Operating Expenses next becoming due. If Lessee's payments under this
Paragraph 4.2(d) during said preceding year were less than Lessee's Share as
indicated on said statement, Lessee shall pay to Lessor the amount of the
deficiency within ten (10) days after delivery by Lessor to Lessee of said
statement.

5.     SECURITY DEPOSIT. Lessee shall deposit with Lessor upon Lessee's
execution hereof the Security Deposit set forth in Paragraph 1.7 as security
for Lessee's faithful performance of Lessee's obligations under this Lease.
If Lessee fails to pay Base Rent or other rent or charges due hereunder, or
otherwise Defaults under this Lease (as defined in Paragraph 13.1), Lessor
may use, apply or retain all or any portion of said Security Deposit for the
payment of any amount due Lessor or to reimburse or compensate Lessor for any
liability, cost, expense, loss or damage (including attorneys' fees) which
Lessor may suffer or incur by reason thereof. If Lessor uses or applies all
or any portion of said Security Deposit, Lessee shall within ten (10) days
after written request therefore deposit monies with Lessor sufficient to
restore said Security Deposit to the full amount required by this Lease.
Lessor shall not be required to keep all or any part of the Security Deposit
separate from its general accounts. Lessor shall, at the expiration or
earlier termination of the term hereof and after Lessee has vacated the
Premises, return to Lessee (or, at Lessor's option, to the last assignee, if
any, of Lessee's interest herein), that portion of the Security Deposit not
used or applied by Lessor. Unless otherwise expressly agreed in writing by
Lessor, no part of the Security Deposit shall be considered to be held in
trust, to bear interest or other increment for its use, or to be prepayment
for any monies to be paid by Lessee under this Lease. (Also see Addendum,
Paragraph__.)

6.     USE.

       6.1     PERMITTED USE.

               (a)     Lessee shall use and occupy the Premises only for the
Permitted Use set forth in Paragraph 1.8, and for no other purpose. Lessee
shall not use or permit the use of the Premises in a manner that is unlawful,
creates waste or a nuisance, or that disturbs owners and/or occupants of, or
causes damage to the Premises or neighboring premises or properties.

               (b)     Any request by Lessee, Lessee's assignees or
subtenants, and by prospective assignees and subtenants of Lessee, its
assignees and subtenants, for a modification of said Permitted Use shall be
in writing and subject to Lessor's reasonable consent. If Lessor elects to
withhold such consent, Lessor shall within five (5) business days after such
request give a written notification of same, which notice shall include an
explanation of Lessor's objections to the change in use.

       6.2     HAZARDOUS SUBSTANCES. (Also see Addendum, Paragraph 59.)

               (a)     REPORTABLE USES REQUIRE CONSENT. The term "HAZARDOUS
SUBSTANCE" as used in this Lease shall mean any product, substance, chemical,
material or waste whose presence, nature, quantity and/or intensity of
existence, use, manufacture, disposal, transportation, spill, release or
effect, either by itself or in combination with other materials expected to
be on the Premises, is either: (i) potentially injurious to the public
health, safety or welfare, the environment, or the Premises; (ii) regulated
or monitored by any governmental authority; or (iii) a basis for potential
liability of Lessor to any governmental agency or third party under any
applicable statute or common law theory. Hazardous Substance shall include,
but not be limited to, hydrocarbons, petroleum, gasoline, crude oil or any
products or by-products thereof. Lessee shall not engage in any activity in
or about the Premises which constitutes a Reportable Use (as hereinafter
defined) of Hazardous Substances without the express prior written consent of
Lessor and compliance in a timely manner (at Lessee's sole cost and expense)
with all Applicable Requirements (as defined in Paragraph 6.3). "REPORTABLE
USE" shall mean (i) the installation or use of any above or below ground
storage tank; (ii) the generation, possession, storage, use, transportation,
or disposal of a Hazardous Substance that requires a permit from, or with
respect to which a report, notice, registration or business plan is required
to be filed with, any governmental authority; and (iii) the presence in, on
or about the Premises of a Hazardous Substance with respect to which any
Applicable Laws require that a notice be given to persons entering or
occupying the Premises or neighboring properties. Notwithstanding the
foregoing, Lessee may, without Lessor's prior consent, but upon notice to
Lessor and in compliance with all Applicable Requirements, use any ordinary
and customary materials reasonably required to be used by Lessee in the
normal course of the Permitted Use, so long as such use is not a Reportable
Use and does not expose the Premises or neighboring properties to any
meaningful risk of contamination or damage or expose Lessor to any liability
therefor. In addition, Lessor may (but without any obligation to do so)
condition its consent to any Reportable Use of any Hazardous Substance by
Lessee upon Lessee's giving Lessor such additional assurances as Lessor, in
its reasonable discretion, deems necessary to protect itself, the public, the
Premises and the environment against damage, contamination or injury and/or
liability therefor, including, but not limited to, the

                                                     Initials:  [ILLEGIBLE]
                                                                   -----------
                                                               NC
                                                               -----

                                   Page 3 of 13
<PAGE>

installation (and, at Lessor's option, removal on or before Lease expiration
or earlier termination) of reasonably necessary protective modifications to
the Premises (such as concrete encasements) and/or the deposit of an
additional Security Deposit under Paragraph 5 hereof.

               (b)     DUTY TO INFORM LESSOR. If Lessee knows, or has
reasonable cause to believe, that a Hazardous Substance has come to be
located in, on, under or about the Premises or the Building, other than as
previously consented to by Lessor, Lessee shall immediately give Lessor
written notice thereof, together with a copy of any statement, report,
notice, registration, application, permit, business plan, license, claim,
action, or proceeding given to, or received from, any governmental authority
or private party concerning the presence, spill, release, discharge of, or
exposure to, such Hazardous Substance including but not limited to, all such
documents as may be involved in any Reportable Use involving the Premises.
Lessee shall not cause or permit any Hazardous Substance to be spilled or
released in, on, under or about the Premises (including, without limitation,
through the plumbing or sanitary sewer system).

               (c)     INDEMNIFICATION. Lessee shall indemnify, protect,
defend and hold Lessor, its agents, employees, lenders and ground lessor, if
any, and the Premises, harmless from and against any and all damages,
liabilities, judgments, costs, claims, liens, expenses, penalties, loss of
permits and attorneys' and consultants' fees arising out of or involving any
Hazardous Substance brought onto the Premises by or for Lessee or by anyone
under Lessee's control. Lessee's obligations under this Paragraph 6.2(c)
shall include, but not be limited to, the effects of any contamination or
injury to person, property or the environment created or suffered by Lessee,
and the cost of investigation (including consultants' and attorneys' fees and
testing), removal, remediation, restoration and/or abatement thereof, or of
any contamination therein involved, and shall survive the expiration or
earlier termination of this Lease. No termination, cancellation or release
agreement entered into by Lessor and Lessee shall release Lessee from its
obligations under this Lease with respect to Hazardous Substances, unless
specifically so agreed by Lessor in writing at the time of such agreement.
Lessor shall indemnify, protect, defend and hold Lessee, its agents and
employees, harmless from and against any and all damages, liabilities,
judgments, costs, claims, liens, expenses, penalties, loss of permits, and
attorneys' and consultants' fees arising out of or involving any Hazardous
Substance brought on to the Premises by or for Lessor, its agents and
employees.

       6.3     LESSEE'S COMPLIANCE WITH REQUIREMENTS. Lessee shall, at
Lessee's sole cost and expense, fully, diligently and in a timely manner,
comply with all "APPLICABLE REQUIREMENTS," which term is used in this Lease
to mean all laws, rules, regulations, ordinances, directives, covenants,
easements and restrictions of record, permits, the requirements of any
applicable fire insurance underwriter or rating bureau, and the
recommendations of Lessor's engineers and/or consultants, relating in any
manner to Lessee's use, occupancy or modification of the Premises (including,
but not limited to, matters pertaining to (i) industrial hygiene; (ii)
environmental conditions on, in, under or about the Premises, including soil
and groundwater conditions; and (iii) the use, generation, manufacture,
production, installation, maintenance, removal, transportation, storage,
spill, or release of any Hazardous Substance), now in effect or which may
hereafter come into effect. Lessee shall, within five (5) days after receipt
of Lessor's written request, provide Lessor with copies of all documents and
information, including, but not limited to, permits, registrations,
manifests, applications, reports and certificates, evidencing Lessee's
compliance with any Applicable Requirements specified by Lessor, and shall
immediately upon receipt, notify Lessor in writing (with copies of any
documents involved) of any threatened or actual claim, notice, citation,
warning, complaint or report pertaining to or involving failure by Lessee or
the Premises to comply with any Applicable Requirements.

       6.4     INSPECTION; COMPLIANCE WITH LAW. Lessor, Lessor's agents,
employees, contractors and designated representatives, and the holders of any
mortgages, deeds of trust or ground leases on the Premises ("LENDERS") shall
have the right to enter the Premises at any time in the case of an emergency,
and otherwise upon reasonable notice to Lessee, for the purpose of inspecting
the condition of the Premises and for verifying compliance by Lessee with
this Lease and all Applicable Requirements (as defined in Paragraph 6.3), and
Lessor shall be entitled to employ experts and/or consultants in connection
therewith to advise Lessor with respect to Lessee's activities, including but
not limited to Lessee's installation, operation, use, monitoring,
maintenance, or removal of any Hazardous Substance on or from the Premises.
The costs and expenses of any such inspections shall be paid by the party
requesting same, unless a Default or Breach of this Lease by Lessee or a
violation of Applicable Requirements or a contamination, caused or materially
contributed to by Lessee, is found to exist or to be imminent, or unless the
inspection is requested or ordered by a governmental authority as the result
of any such existing or imminent violation or contamination. In such case,
Lessee shall upon request reimburse Lessor or Lessor's Lender, as the case
may be, for the costs and expenses of such inspections. (Also see Addendum,
Paragraph 55.)

7.     MAINTENANCE, REPAIRS, UTILITY INSTALLATIONS, TRADE FIXTURES AND
ALTERATIONS.

       7.1     LESSEE'S OBLIGATIONS.

               (a)     Subject to the provisions of Paragraphs 2.2 (Condition),
2.3 (Compliance with Covenants, Restrictions and Building Code), 7.2
(Lessor's Obligations), 9 (Damage or Destruction), and 14 (Condemnation),
Lessee shall, at Lessee's sole cost and expense and at all times, keep the
Premises and every part thereof in good order, condition and repair (whether
or not such portion of the Premises requiring repair, or the means of
repairing the same, are reasonably or readily accessible to Lessee, and
whether or not the need for such repairs occurs as a result of Lessee's use,
any prior use, the elements or the age of such portion of the Premises),
including, without limiting the generality of the foregoing, all equipment or
facilities specifically serving the Premises, such as plumbing, heating, air
conditioning, ventilating, electrical, lighting facilities, boilers, fired or
unfired pressure vessels, fire hose connections if within the Premises,
fixtures, interior walls, interior surfaces of exterior walls, ceilings,
floors, windows, doors, plate glass, and skylights, but excluding any items
which are the responsibility of Lessor pursuant to Paragraph 7.2 below.
Lessee, in keeping the Premises in good order, condition and repair, shall
exercise and perform good maintenance practices. Lessee's obligations shall
include restorations, replacements or renewals when necessary to keep the
Premises and all improvements thereon or a part thereof in good order,
condition and state of repair.

               (b)     Lessee shall, at Lessee's sole cost and expense,
procure and maintain a contract, with copies to Lessor, in customary form and
substance for and with a contractor specializing and experienced in the
inspection, maintenance and service of the heating, air conditioning and
ventilation system for the Premises. However, Lessor reserves the right, upon
notice to Lessee, to procure and maintain the contract for the heating, air
conditioning and ventilating systems, and if Lessor so elects, Lessee shall
reimburse Lessor, upon demand, for the cost thereof.

               (c)     If Lessee fails to perform Lessee's obligations under
this Paragraph 7.1, Lessor may enter upon the Premises after ten (10) days'
prior written notice to Lessee (except in the case of an emergency, in which
case no notice shall be required), perform such obligations on Lessee's
behalf, and put the Premises in good order, condition and repair, in
accordance with Paragraph 13.2 below.

       7.2     LESSOR'S OBLIGATIONS. Subject to the provisions of Paragraphs
2.2 (Condition), 2.3 (Compliance with Covenants, Restrictions and Building
Code), 4.2 (Common Area Operating Expenses), 6 (Use), 7.1 (Lessee's
Obligations), 9 (Damage or Destruction) and 14 (Condemnation), Lessor,
subject to reimbursement pursuant to Paragraph 4.2, shall keep in good order,
condition and repair the foundations, exterior walls, structural condition of
interior bearing walls, exterior roof, fire sprinkler and/or standpipe and
hose (if located in the Common Areas) or other automatic fire extinguishing
system including fire alarm and/or smoke detection systems and equipment,
fire hydrants, parking lots, walkways, parkways, driveways, landscaping,
fences, signs and utility systems serving the Common Areas and all parts
thereof, as well as providing the services for which there is a Common Area
Operating Expense pursuant to Paragraph 4.2. Lessor shall not be obligated to
paint the exterior or interior surfaces of exterior walls nor shall Lessor be
obligated to maintain, repair or replace windows, doors or plate glass of the
Premises. Lessee expressly waives the benefit of any statute now or hereafter
in effect which would otherwise afford Lessee the right to make repairs at
Lessor's expense or to terminate this Lease because of Lessor's failure to
keep the Building, Industrial Center or Common Areas in good order, condition
and repair.

       7.3     UTILITY INSTALLATIONS, TRADE FIXTURES, ALTERATIONS.

               (a)     DEFINITIONS; CONSENT REQUIRED. The term "UTILITY
INSTALLATIONS" is used in this Lease to refer to all air lines, power panels,
electrical distribution, security, fire protection systems, communications
systems, lighting fixtures, heating, ventilating and air conditioning
equipment, plumbing, and fencing in, on or about the Premises. The term
"TRADE FIXTURES" shall mean Lessee's machinery and equipment which can be
removed without doing material damage to the Premises. The term
"ALTERATIONS" shall mean any modification of the improvements on the Premises
which are provided by Lessor under the terms of this Lease, other than
Utility Installations or Trade Fixtures. "LESSEE-OWNED ALTERATIONS AND/OR
UTILITY INSTALLATIONS" are defined as Alterations and/or Utility
Installations made by Lessee that are not yet owned by Lessor pursuant to
Paragraph 7.4(a). Lessee shall not make nor cause to be made any Alterations
or Utility Installations in, on, under or about the Premises without Lessor's
prior written consent.

               (b)     CONSENT. Any Alterations or Utility Installations that
Lessee shall desire to make and which require the consent of the Lessor shall
be presented to Lessor in written form with detailed plans. All consents
given by Lessor, whether by virtue of Paragraph 7.3(a) or by subsequent
specific consent, shall be deemed conditioned upon: (i) Lessee's acquiring
all applicable permits required by governmental authorities; (ii) the
furnishing of copies of such permits together with a copy of the plans and
specifications for the Alteration or Utility Installation to Lessor prior to
commencement of the work thereon; and (iii) the compliance by Lessee with all
conditions of said permits in a prompt and expeditious manner. Any
Alterations or Utility Installations by Lessee

                                                     Initials:   [ILLEGIBLE]
                                                                    -----------
                                                               NC
                                                               -----

                                   Page 4 of 13
<PAGE>

during the term of this Lease shall be done in a good and workmanlike manner,
with good and sufficient materials, and be in compliance with all Applicable
Requirements. Lessee shall promptly upon completion thereof furnish Lessor
with as-built plans and specifications therefor. Lessor may, (but without
obligation to do so) condition its consent to any requested Alteration or
Utility Installation that costs $10,000.00 or more upon Lessee's providing
Lessor with a lien and completion bond in an amount equal to one and one-half
times the estimated cost of such Alteration or Utility Installation.

               (c) LIEN PROTECTION. Lessee shall pay when due all claims for
labor or materials furnished or alleged to have been furnished to or for
Lessee at or for use on the Premises, which claims are or may be secured by
any mechanic's or materialmen's lien against the Premises or any interest
therein. Lessee shall give Lessor not less than ten (10) days' notice prior
to the commencement of any work in, on, or about the Premises, and Lessor
shall have the right to post notices of non-responsibility in or on the
Premises as provided by law. If Lessee shall, in good faith, contest the
validity of any such lien, claim or demand, then Lessee shall, at its sole
expense, defend and protect itself, Lessor and the Premises against the same
and shall pay and satisfy any such adverse judgment that may be rendered
thereon before the enforcement thereof against the Lessor or the Premises. If
Lessor shall require, Lessee shall furnish to Lessor a surety bond
satisfactory to Lessor, in an amount equal to one and one-half times the
amount of such contested lien claim or demand, indemnifying Lessor against
liability for the same, as required by law for the holding of the Premises
free from the effect of such lien or claim. In addition, Lessor may require
Lessee to pay Lessor's attorneys' fees and costs in participating in such
action if Lessor shall decide it is to its best interest to do so.

       7.4     OWNERSHIP, REMOVAL, SURRENDER, AND RESTORATION.

               (a) OWNERSHIP. Subject to Lessor's right to require their
removal and to cause Lessee to become the owner thereof as hereinafter
provided in this Paragraph 7.4, all Alterations and Utility Installations
made to the Premises by Lessee shall be the property of and owned by Lessee,
but considered a part of the Premises. Lessor may, at any time and at its
option, elect in writing to Lessee to be the owner of all or any specified
part of the Lessee-Owned Alterations and Utility Installations. Unless
otherwise instructed per Subparagraph 7.4(b) hereof, all Lessee-Owned
Alterations and Utility Installations shall, at the expiration or earlier
termination of this Lease, become the property of Lessor and remain upon the
Premises and be surrendered with the Premises by Lessee.

               (b) REMOVAL. Unless otherwise agreed in writing, Lessor may
require that any or all Lessee-Owned Alterations or Utility Installations be
removed by the expiration or earlier termination of this Lease,
notwithstanding that their installation may have been consented to by Lessor.
Lessor may require the removal at any time of all or any part of any
Alterations or Utility Installations made without the required consent of
Lessor. Notwithstanding the above, Lessee shall not be required to remove
those Improvements, Alterations or Utility Installations which are part of
Lessee's Premises, unless Lessor notifies Lessee of its obligation to remove
said Improvement,  Alteration or Utility Installation at the time Lessor
approves construction or installation of said Improvement, Alteration or
Utility Installation.

               (c) SURRENDER/RESTORATION. Lessee shall surrender the Premises
by the end of the last day of the Lease term or any earlier termination date,
clean and free of debris and in good operating order, condition and state of
repair, ordinary wear and tear excepted. Ordinary wear and tear shall not
include any damage or deterioration that would have been prevented by good
maintenance practice or by Lessee performing all of its obligations under
this Lease. Except as otherwise agreed or specified herein, the Premises, as
surrendered, shall include the Alterations and Utility Installations. The
obligation of Lessee shall include the repair of any damage occasioned by the
installation, maintenance or removal of Lessee's Trade Fixtures, furnishings,
equipment, and Lessee-Owned Alterations and Utility Installations, as well as
the removal of any storage tank installed by or for Lessee, and the removal,
replacement, or remediation of any soil, material or ground water
contaminated by Lessee, all as may then be required by Applicable
Requirements and/or good practice. Lessee's Trade Fixtures shall remain the
property of Lessee and shall be removed by Lessee subject to its obligation
to repair and restore the Premises per this Lease.

8.     INSURANCE; INDEMNITY. (Also see Addendum, Paragraph 56.)

       8.1     PAYMENT OF PREMIUMS. The cost of the premiums for the
insurance policies maintained by Lessor under this Paragraph 8 shall be a
Common Area Operating Expense pursuant to Paragraph 4.2 hereof. Premiums for
policy periods commencing prior to, or extending beyond, the term of this
Lease shall be prorated to coincide with the corresponding Commencement Date
or Expiration Date.

       8.2     LIABILITY INSURANCE.

               (a) CARRIED BY LESSEE. Lessee shall obtain and keep in force
during the term of this Lease a Commercial General Liability policy of
insurance protecting Lessee, Lessor and any Lender(s) whose names have been
provided to Lessee in writing (as additional insureds) against claims for
bodily injury, personal injury and property damage based upon, involving or
arising out of the ownership, use, occupancy or maintenance of the Premises
and all areas appurtenant thereto. Such insurance shall be on an occurrence
basis providing single limit coverage in an amount not less than $1,000,000
per occurrence with an "Additional Insured-Managers or Lessors of Premises"
endorsement and contain the "Amendment to the Pollution Exclusion"
endorsement for damage caused by heat, smoke or fumes from a hostile fire.
The policy shall not contain any intra-insured exclusions as between insured
persons or organizations, but shall include coverage for liability assumed
under this Lease as an "INSURED CONTRACT" for the performance of Lessee's
indemnity obligations under this Lease. The limits of said insurance required
by this Lease or as carried by Lessee shall not, however, limit the liability
of Lessee nor relieve Lessee of any obligation hereunder. All insurance to be
carried by Lessee shall be primary to and not contributory with any similar
insurance carried by Lessor, whose insurance shall be considered excess
insurance only.

               (b) CARRIED BY LESSOR. Lessor shall also maintain liability
insurance described in Paragraph 8.2(a) above, in addition to and not in lieu
of, the insurance required to be maintained by Lessee. Lessee shall not be
named as an additional insured therein.

       8.3     PROPERTY INSURANCE - BUILDING, IMPROVEMENTS AND RENTAL VALUE.

               (a) BUILDING AND IMPROVEMENTS. Lessor shall obtain and keep in
force during the term of this Lease a policy or policies in the name of
Lessor, with loss payable to Lessor and to any Lender(s), insuring against
loss or damage to the Premises. Such insurance shall be for full replacement
cost, as the same shall exist from time to time, or the amount required by
any Lender(s), but in no event more than the commercially reasonable and
available insurable value thereof if, by reason of the unique nature or age
of the improvements involved, such latter amount is less than full
replacement cost. Lessee-Owned Alterations and Utility Installations, Trade
Fixtures and Lessee's personal property shall be insured by Lessee pursuant
to Paragraph 8.4. If the coverage is available and commercially appropriate,
Lessor's policy or policies shall insure against all risks of direct physical
loss or damage (except the perils of flood and/or earthquake unless required
by a Lender), including coverage for any additional costs resulting from
debris removal and reasonable amounts of coverage for the enforcement of any
ordinance or law regulating the reconstruction or replacement of any
undamaged sections of the Building required to be demolished or removed by
reason of the enforcement of any building, zoning, safety or land use laws as
the result of a covered loss, but not including plate glass insurance. Said
policy or policies shall also contain an agreed valuation provision in lieu
of any co-insurance clause, waiver of subrogation, and inflation guard
protection causing an increase in the annual property insurance coverage
amount by a factor of not less than the adjusted U.S. Department of Labor
Consumer Price Index for All Urban Consumers for the city nearest to where
the Premises are located.

               (b) RENTAL VALUE. Lessor shall also obtain and keep in force
during the term of this Lease a policy or policies in the name of Lessor,
with loss payable to Lessor and any Lender(s), insuring the loss of the full
rental and other charges payable by all lessees of the Building to Lessor for
one year (including all Real Property Taxes, insurance costs, all Common Area
Operating Expenses and any scheduled rental increases). Said insurance may
provide that in the event the Lease is terminated by reason of an insured
loss, the period of indemnity for such coverage shall be extended beyond the
date of the completion of repairs or replacement of the Premises, to provide
for one full year's loss of rental revenues from the date of any such loss.
Said insurance shall contain an agreed valuation provision in lieu of any
co-insurance clause, and the amount of coverage shall be adjusted annually to
reflect the projected rental income, Real Property Taxes, insurance premium
costs and other expenses, if any, otherwise payable, for the next 12-month
period. Common Area Operating Expenses shall include any deductible amount in
the event of such loss.

               (c) ADJACENT PREMISES. Lessee shall pay for any increase in
the premiums for the property insurance of the Building and for the Common
Areas or other buildings in the Industrial Center if said increase is caused
by Lessee's acts, omissions, use or occupancy of the Premises.

               (d) LESSEE'S IMPROVEMENTS. Since Lessor is the Insuring Party,
Lessor may, but shall not be required to insure Lessee-Owned Alterations and
Utility Installations unless the item in question has become the property of
Lessor under the terms of this Lease.

       8.4     LESSEE'S PROPERTY INSURANCE. Subject to the requirements of
Paragraph 8.5, Lessee at its cost shall either by separate policy or, at
Lessor's option, by endorsement to a policy already carried, maintain
insurance coverage on all of Lessee's personal property, Trade Fixtures and
Lessee-Owned Alterations and Utility Installations in, on, or about the
Premises similar in coverage to that carried by Lessor as the Insuring Party
under Paragraph 8.3(a). Such insurance shall be full replacement cost
coverage with a deductible not to exceed $1,000 per occurrence. The proceeds
from any such insurance shall be used by Lessee for the replacement of
personal property and the restoration of Trade Fixtures and Lessee-Owned
Alterations and Utility Installations. Upon request from Lessor, Lessee shall
provide Lessor with written evidence that such insurance is in force.

       8.5     INSURANCE POLICIES. Insurance required hereunder shall be in
companies duly licensed to transact business in the state where the Premises
are

                                                           INITIALS: [ILLEGIBLE]
                                                                     -----------
                                                                      NC
                                                                     -----------

                            Page 5 of 13

<PAGE>

located, and maintaining during the policy term a "General Policyholders
Rating" of at least A:XIII, or such other rating as may be required by a
Lender, as set forth in the most current issue of "Best's Insurance Guide."
Lessee shall not do or permit to be done anything which shall invalidate the
insurance policies referred to in this Paragraph 8. Lessee shall cause to be
delivered to Lessor, within seven (7) days after the earlier of the Early
Possession Date or the Commencement Date, certified copies of, or
certificates evidencing the existence and amounts of, the insurance required
under Paragraph 8.2(a) and 8.4.  No such policy shall be cancelable or
subject to modification except after thirty (30) days' prior written notice
to Lessor. Lessee shall, at least thirty (30) days prior to the expiration of
such policies, furnish Lessor with evidence of renewals or "insurance
binders" evidencing renewal thereof, or Lessor may order such insurance and
charge the cost thereof to Lessee, which amount shall be payable by Lessee to
Lessor upon demand.

       8.6     WAIVER OF SUBROGATION. Without affecting any other rights or
remedies, Lessee and Lessor each hereby release and relieve the other, and
waive their entire right to recover damages (whether in contract or in tort)
against the other, for loss or damage to their property arising out of or
incident to the perils required to be insured against under Paragraph 8.  The
effect of such releases and waivers of the right to recover damages shall not
be limited by the amount of insurance carried or required, or by any
deductibles applicable thereto.  Lessor and Lessee agree to have their
respective insurance companies issuing property damage insurance waive any
right to subrogation that such companies may have against Lessor or Lessee,
as the case may be, so long as the insurance is not invalidated thereby.

       8.7     INDEMNITY. Except for Lessor's, its agent's or employee's
gross negligence, willful misconduct and/or breach of express warranties,
Lessee shall indemnify, protect, defend and hold harmless the Premises,
Lessor and its agents, Lessor's master or ground lessor, partners and
Lenders, from and against any and all claims, loss of rents and/or damages,
costs, liens, judgments, penalties, loss of permits, attorneys' and
consultants' fees, expenses and/or liabilities arising out of, involving, or
in connection with, the occupancy of the Premises by Lessee, the conduct of
Lessee's business, any act, omission or neglect of Lessee, its agents,
contractors, employees or invitees, and out of any Default or Breach by
Lessee in the performance in a timely manner of any obligation on Lessee's
part to be performed under this Lease.  The foregoing shall include, but not
be limited to, the defense or pursuit of any claim or any action or
proceeding involved therein, and whether or not (in the case of claims made
against Lessor) litigated and/or reduced to judgment.  In case any action or
proceeding be brought against Lessor by reason of any of the foregoing
matters, Lessee, upon notice from Lessor, shall defend the same at Lessee's
expense by counsel reasonably satisfactory to Lessor and Lessor shall
cooperate with Lessee in such defense.  Lessor need not have first paid any
such claim in order to be so indemnified.

       8.8     EXEMPTION OF LESSOR FROM LIABILITY. Lessor shall not be liable
for injury or damage to the person or goods, wares, merchandise or other
property of Lessee, Lessee's employees, contractors, invitees, customers, or
any other person in or about the Premises, whether such damage or injury is
caused by or results from fire, steam, electricity, gas, water or rain, or
from the breakage, leakage, obstruction or other defects of pipes, fire
sprinklers, wires, appliances, plumbing, air conditioning or lighting
fixtures, or from any other cause, whether said injury or damage results from
conditions arising upon the Premises or upon other portions of the Building
of which the Premises are a part, from other sources or places, and
regardless of whether the cause of such damage or injury or the means of
repairing the same is accessible or not. Lessor shall not be liable for any
damages arising from any act or neglect of any other lessee of Lessor nor
from the failure by Lessor to enforce the provisions of any other lease in
the Industrial Center.  Notwithstanding Lessor's negligence or breach of this
Lease, Lessor shall under no circumstances be liable for injury to Lessee's
business or for any loss of income or profit therefrom.

9.     DAMAGE OR DESTRUCTION.

       9.1     DEFINITIONS.

               (a) "PREMISES PARTIAL DAMAGE" shall mean damage or destruction
to the Premises, other than Lessee-Owned Alterations and Utility
Installations, the repair cost of which damage or destruction is less than
twenty-five percent (25%) of the then Replacement Cost (as defined in
Paragraph 9.1(d)) of the Premises (excluding Lessee-Owned Alterations and
Utility Installations and Trade Fixtures) immediately prior to such damage or
destruction.

               (b) "PREMISES TOTAL DESTRUCTION" shall mean damage or
destruction to the Premises, other than Lessee-Owned Alterations and Utility
Installations, the repair cost of which damage or destruction is twenty-five
percent (25%) or more of the then Replacement Cost of the Premises (excluding
Lessee-Owned Alterations and Utility Installations and Trade Fixtures)
immediately prior to such damage or destruction.  In addition, damage or
destruction to the Building, other than Lessee-Owned Alterations and Utility
Installations and Trade Fixtures of any lessees of the Building, the cost of
which damage or destruction is twenty-five percent (25%) or more of the then
Replacement Cost (excluding Lessee-Owned Alterations and Utility
Installations and Trade Fixtures of any lessees of the Building) of the
Building shall, at the option of Lessor, be deemed to be Premises Total
Destruction.

               (c) "INSURED LOSS" shall mean damage or destruction to the
Premises, other than Lessee-Owned Alterations and Utility Installations and
Trade Fixtures, which was caused by an event required to be covered by the
insurance described in Paragraph 8.3(a) irrespective of any deductible
amounts or coverage limits involved.

               (d) "REPLACEMENT COST" shall mean the cost to repair or
rebuild the improvements owned by Lessor at the time of the occurrence to
their condition existing immediately prior thereto, including demolition,
debris removal and upgrading required by the operation of applicable building
codes, ordinances or laws, and without deduction for depreciation.

               (e) "HAZARDOUS SUBSTANCE CONDITION" shall mean the occurrence
or discovery of a condition involving the presence of, or a contamination by,
a Hazardous Substance as defined in Paragraph 6.2(a), in, on, or under the
Premises.

       9.2     PREMISES PARTIAL DAMAGE - INSURED LOSS. If Premises Partial
Damage that is an Insured Loss occurs, then Lessor shall, at Lessor's
expense, repair such damage (but not Lessee's Trade Fixtures or Lessee-Owned
Alterations and Utility Installations) as soon as reasonably possible and
this Lease shall continue in full force and effect.  In the event, however,
that there is a shortage of insurance proceeds and such shortage is due to
the fact that, by reason of the unique nature of the improvements in the
Premises, full replacement cost insurance coverage was not commercially
reasonable and available, Lessor shall have no obligation to pay for the
shortage in insurance proceeds or to fully restore the unique aspects of the
Premises unless Lessee provides Lessor with the funds to cover same, or
adequate assurance thereof, within ten (10) days following receipt of written
notice of such shortage and request therefor.  If Lessor receives said funds
or adequate assurance thereof within said ten (10) day period, Lessor shall
complete them as soon as reasonably possible and this Lease shall remain in
full force and effect.  If Lessor does not receive such funds or assurance
within said period, Lessor may nevertheless elect by written notice to Lessee
within ten (10) days thereafter to make such restoration and repair as is
commercially reasonable with Lessor paying any shortage in proceeds, in which
case this Lease shall remain in full force and effect.  If Lessor does not
receive such funds or assurance within such ten (10) day period, and if
Lessor does not so elect to restore and repair, then this Lease shall
terminate sixty (60) days following the occurrence of the damage or
destruction.  Unless otherwise agreed, Lessee shall in no event have any
right to reimbursement from Lessor for any funds contributed by Lessee to
repair any such damage or destruction.  Premises Partial Damage due to flood
or earthquake shall be subject to Paragraph 9.3 rather than Paragraph 9.2,
notwithstanding that there may be some insurance coverage, but the net
proceeds of any such insurance shall be made available for the repairs if
made by either Party.

       9.3     PARTIAL DAMAGE - UNINSURED LOSS. If Premises Partial Damage
that is not an Insured Loss occurs, unless caused by a negligent or willful
act of Lessee (in which event Lessee shall make the repairs at Lessee's
expense and this Lease shall continue in full force and effect), Lessor may,
at Lessor's option, either (i) repair such damage as soon as reasonably
possible at Lessor's expense, in which event this Lease shall continue in
full force and effect, or (ii) give written notice to Lessee within thirty
(30) days after receipt by Lessor of knowledge of the occurrence of such
damage of Lessor's desire to terminate this Lease as of the date sixty (60)
days following the date of such notice.  In the event Lessor elects to give
such notice of Lessor's intention to terminate this Lease, Lessee shall have
the right within ten (10) days after the receipt of such notice to give
written notice to Lessor of Lessee's commitment to pay for the repair of such
damage totally at Lessee's expense and without reimbursement from Lessor.
Lessee shall provide Lessor with the required funds or satisfactory assurance
thereof within thirty (30) days following such commitment from Lessee.  In
such event this Lease shall continue in full force and effect, and Lessor
shall proceed to make such repairs as soon as reasonably possible after the
required funds are available.  If Lessee does not give such notice and
provide the funds or assurance thereof within the times specified above, this
Lease shall terminate as of the date specified in Lessor's notice of
termination.

       9.4     TOTAL DESTRUCTION. Notwithstanding any other provision hereof,
if Premises Total Destruction occurs (including any destruction required by
any authorized public authority), this Lease shall terminate sixty (60) days
following the date of such Premises Total Destruction, whether or not the
damage or destruction is an Insured Loss or was caused by a negligent or
willful act of Lessee.  In the event, however, that the damage or destruction
was caused by Lessee, Lessor shall have the right to recover Lessor's damages
from Lessee except as released and waived in Paragraph 9.7.

       9.5     DAMAGE NEAR END OF TERM. If at any time during the last six
(6) months of the term of this Lease there is damage for which the cost to
repair exceeds one month's Base Rent, whether or not an Insured Loss, Lessor
may, at Lessor's option, terminate this Lease effective sixty (60) days
following the date of occurrence of such damage by giving written notice to
Lessee of Lessor's election to do so within thirty (30) days after the date
of occurrence of such

                                                           INITIALS: [ILLEGIBLE]
                                                                     -----------
                                                                      NC
                                                                     -----------

                            Page 6 of 13

<PAGE>

damage.  Provided, however, if Lessee at that time has an exercisable option to
extend this Lease or to purchase the Premises, then Lessee may preserve this
Lease by (a) exercising such option, and (b) providing Lessor with any shortage
in insurance proceeds (or adequate assurance thereof) needed to make the
repairs on or before the earlier of (i) the date which is ten (10) days after
Lessee's receipt of Lessor's written notice purporting to terminate this Lease,
or (ii) the day prior to the date upon which such option expires.  If Lessee
duly exercises such option during such period and provides Lessor with funds (or
adequate assurance thereof) to cover any shortage in insurance proceeds, Lessor
shall, at Lessor's expense, repair such damage as soon as reasonably possible
and this Lease shall continue in full force and effect.  If Lessee fails to
exercise such option and provide such funds or assurance during such period,
then this Lease shall terminate as of the date set forth in the first sentence
of this Paragraph 9.5.

       9.6     ABATEMENT OF RENT; LESSEE'S REMEDIES.

               (a)     In the event of Premises Partial Damage, the Base
Rent, Common Area Operating Expenses and other charges, if any, payable by
Lessee hereunder for the period during which such damage or condition, its
repair, remediation or restoration continues, shall be abated in proportion
to the degree to which Lessee's use of the Premises is impaired, but not in
excess of proceeds from insurance required to be carried under Paragraph
8.3(b). Except for abatement of Base Rent, Common Area Operation Expenses and
other charges, if any, as aforesaid, all other obligations of Lessee
hereunder shall be performed by Lessee, and Lessee shall have no claim
against Lessor for any damage suffered by reason of any such damage,
destruction, repair, remediation or restoration.

               (b)     If Lessor shall be obligated to repair or restore the
Premises under the provisions of this Paragraph 9 and shall not commence, in
a substantial and meaningful way, the repair or restoration of the Premises
within ninety (90) days after such obligation shall accrue, Lessee may, at
any time prior to the commencement of such repair or restoration, give
written notice to Lessor and to any Lenders of which Lessee has actual notice
of Lessee's election to terminate this Lease on a date not less than sixty
(60) days following the giving of such notice.  If Lessee gives such notice
to Lessor and such Lenders and such repair or restoration is not commenced
within thirty (30) days after receipt of such notice, this Lease shall
terminate as of the date specified in said notice.  If Lessor or a Lender
commences the repair or restoration of the Premises within thirty (30) days
after the receipt of such notice, this Lease shall continue in full force and
effect.  "COMMENCE" as used in this Paragraph 9.6 shall mean either the
unconditional authorization of the preparation of the required plans, or the
beginning of the actual work on the Premises, whichever occurs first.

       9.7     HAZARDOUS SUBSTANCE CONDITIONS. If a Hazardous Substance
Condition occurs, unless Lessee is legally responsible therefor (in which case
Lessee shall make the investigation and remediation thereof required by
Applicable Requirements and this Lease shall continue in full force and effect,
but subject to Lessor's rights under Paragraph 6.2(c) and Paragraph 13), Lessor
may, at Lessor's option, either (i) investigate and remediate such Hazardous
Substance Condition, if required, as soon as reasonably possible at Lessor's
expense, in which event this Lease shall continue in full force and effect, or
(ii) if the estimated cost to investigate and remediate such condition exceeds
twelve (12) times the then monthly Base Rent or $100,000, whichever is greater,
give written notice to Lessee within thirty (30) days after receipt by Lessor
of knowledge of the occurrence of such Hazardous Substance Condition of
Lessor's desire to terminate this Lease as of the date sixty (60) days
following the date of such notice.  In the event Lessor elects to give such
notice of Lessor's intention to terminate this Lease, Lessee shall have the
right within ten (10) days after the receipt of such notice to give written
notice to Lessor of Lessee's commitment to pay for the excess costs of (a)
investigation and remediation of such Hazardous Substance Condition to the
extent required by Applicable Requirements, over (b) an amount equal to twelve
(12) times the then monthly Base Rent or $100,000, whichever is greater.
Lessee shall provide Lessor with the funds required of Lessee or satisfactory
assurance thereof within thirty (30) days following said commitment by Lessee.
In such event this Lease shall continue in full force and effect, and Lessor
shall proceed to make such investigation and remediation as soon as reasonably
possible after the required funds are available.  If Lessee does not give such
notice and provide the required funds or assurance thereof within the time
period specified above, this Lease shall terminate as of the date specified in
Lessor's notice of termination.

       9.8     TERMINATION - ADVANCE PAYMENTS. Upon termination of this Lease
pursuant to this Paragraph 9, Lessor shall return to Lessee any advance payment
made by Lessee to Lessor and so much of Lessee's Security Deposit as has not
been, or is not then required to be, used by Lessor under the terms of this
Lease.

       9.9     WAIVER OF STATUTES. Lessor and Lessee agree that the terms of
this Lease shall govern the effect of any damage to or destruction of the
Premises and the Building with respect to the termination of this Lease and
hereby waive the provisions of any present or future statute to the extent it is
inconsistent herewith.

10.    REAL PROPERTY TAXES.

       10.1    PAYMENT OF TAXES. Lessor shall pay the Real Property Taxes, as
defined in Paragraph 10.2, applicable to the Industrial Center, and except as
otherwise provided in Paragraph 10.3, any such amounts shall be included in the
calculation of Common Area Operating Expenses in accordance with the provisions
of Paragraph 4.2.

       10.2  REAL PROPERTY TAX DEFINITION. As used herein, the term "REAL
PROPERTY TAXES" shall include any form of real estate tax or assessment,
general, special, ordinary or extraordinary, and any license fee, commercial
rental tax, improvement bond or bonds, levy or tax (other than inheritance,
personal income or estate taxes) imposed upon the Industrial Center by any
authority having the direct or indirect power to tax, including any city, state
or federal government, or any school, agricultural, sanitary, fire, street,
drainage, or other improvement district thereof, levied against any legal or
equitable interest of Lessor in the Industrial Center or any portion thereof,
Lessor's right to rent or other income therefrom, and/or Lessor's business of
leasing the Premises.  The term "REAL PROPERTY TAXES" shall also include any
tax, fee, levy, assessment or charge, or any increase therein, imposed by reason
on events occurring, or changes in Applicable Law taking effect, during the term
of this Lease, including but not limited to, a change in the ownership of the
Industrial Center or in the improvements thereon, the execution of this Lease,
or any modification, amendment or transfer thereof, and whether or not
contemplated by the Parties.  In calculating Real Property Taxes for any
calendar year, the Real Property Taxes for any real estate tax year shall be
included in the calculation of Real Property Taxes for such calendar year based
upon the number of days which such calendar year and tax year have in common.

       10.3    ADDITIONAL IMPROVEMENTS. Common Area Operating Expenses shall
not include Real Property Taxes specified in the tax assessor's records and work
sheets as being caused by additional improvements placed upon the Industrial
Center by other lessees or by Lessor for the exclusive enjoyment of such other
lessees.  Notwithstanding Paragraph 10.1 hereof, Lessee shall, however, pay to
Lessor at the time Common Area Operating Expenses are payable under Paragraph
4.2, the entirety of any increase in Real Property Taxes if assessed solely by
reason of Alterations, Trade Fixtures or Utility Installations placed upon the
Premises by Lessee or at Lessee's request.

       10.4    JOINT ASSESSMENT. If the Building is not separately assessed,
Real Property Taxes allocated to the Building shall be an equitable proportion
of the Real Property Taxes for all of the land and improvements included within
the tax parcel assessed, such proportion to be determined by Lessor from the
respective valuations assigned in the assessor's work sheets or such other
information as may be reasonably available.  Lessor's reasonable determination
thereof, in good faith, shall be conclusive.

       10.5    LESSEE'S PROPERTY TAXES. Lessee shall pay prior to delinquency
all taxes assessed against and levied upon Lessee-Owned Alterations and Utility
Installations, Trade Fixtures, furnishings, equipment and all personal property
of Lessee contained in the Premises or stored within the Industrial Center.
When possible, Lessee shall cause its Lessee-Owned Alterations and Utility
Installations, Trade Fixtures, furnishings, equipment and all other personal
property to be assessed and billed separately from the real property of Lessor.
If any of Lessee's said property shall be assessed with Lessor's real property,
Lessee shall pay Lessor the taxes attributable to Lessee's property within ten
(10) days after receipt of a written statement setting forth the taxes
applicable to Lessee's property.

11.    UTILITIES. Lessee shall pay directly for all utilities and services
supplied to the Premises, including, but not limited to, electricity, telephone,
security, gas and cleaning of the Premises, together with any taxes thereon.  If
any such utilities or services are not separately metered to the Premises or
separately billed to the Premises, Lessee shall pay to Lessor a reasonable
proportion to be determined by Lessor of all such charges jointly metered or
billed with other premises in the Building, in the manner and within the time
periods set forth in Paragraph 4.2(d).

12.    ASSIGNMENT AND SUBLETTING. (Also see Addendum, Paragraph 57.)

       12.1    LESSOR'S CONSENT REQUIRED.

               (a)     Lessee shall not voluntarily or by operation of law
assign, transfer, mortgage or otherwise transfer or encumber (collectively,
"assign") or sublet all or any part of Lessee's interest in this Lease or in the
Premises without Lessor's prior written consent given under and subject to the
terms of Paragraph 36.

               (b)     A direct or indirect change in the control of Lessee
shall constitute an assignment requiring Lessor's consent.  The direct or
indirect transfer, on a cumulative basis, of fifty percent (50%) or more of the
voting control of Lessee shall constitute a change in control for this purpose.

               (c)     The direct or indirect involvement of Lessee or its
assets in any transaction, or series of transactions (by way of merger, sale,
acquisition, financing, refinancing, transfer, leveraged buy-out or otherwise),
whether or not a formal assignment or hypothecation of this Lease or Lessee's
assets

                                                           Initials: [ILLEGIBLE]
                                                                     -----------
                                                                          NC
                                                                     -----------
                                 Page 7 of 13
<PAGE>

occurs, which results or will result in a reduction of the Net Worth of
Lessee, as hereinafter defined, by an amount equal to or greater than
twenty-five percent (25%) of such Net Worth of Lessee as it was represented to
Lessor at the time of full execution and delivery of this Lease or at the time
of the most recent assignment to which Lessor has consented, or as it exists
immediately prior to said transaction or transactions constituting such
reduction, at whichever time said Net Worth of Lessee was or is greater, shall
be considered an assignment of this Lease by Lessee to which Lessor may
reasonably withhold its consent.  "NET WORTH OF LESSEE" for purposes of this
Lease shall be the net worth of Lessee (excluding any Guarantors) established
under generally accepted accounting principles consistently applied.

               (d)     An assignment or subletting of Lessee's interest in
this Lease without Lessor's specific prior written consent shall, at Lessor's
option, be a Default curable after notice per Paragraph 13.1, or a
non-curable Breach without the necessity of any notice and grace period.  If
Lessor elects to treat such unconsented to assignment or subletting as a
non-curable Breach, Lessor shall have the right to either: (i) terminate this
Lease, or (ii) upon thirty (30) days' written notice ("LESSOR'S NOTICE"),
increase the monthly Base Rent for the Premises to the greater of the then
fair market rental value of the Premises, as reasonably determined by Lessor,
or one hundred ten percent (110%) of the Base Rent then in effect.  Pending
determination of the new fair market rental value, if disputed by Lessee,
Lessee shall pay the amount set forth in Lessor's Notice, with any
overpayment credited against the next installment(s) of Base Rent coming due,
and any underpayment for the period retroactively to the effective date of
the adjustment being due and payable immediately upon the determination
thereof. Further, in the event of such Breach and rental adjustment, (i) the
purchase price of any option to purchase the Premises held by Lessee shall be
subject to similar adjustment to the then fair market value as reasonably
determined by Lessor (without the Lease being considered an encumbrance or
any deduction for depreciation or obsolescence, and considering the Premises
at its highest and best use and in good condition) or one hundred ten percent
(110%) of the price previously in effect, (ii) any index-oriented rental or
price adjustment formulas contained in this Lease shall be adjusted to
require that the base index be determined with reference to the index
applicable to the time of such adjustment, and (iii) any fixed rental
adjustments scheduled during the remainder of the Lease term shall be
increased in the same ratio as the new rental bears to the Base Rent in
effect immediately prior to the adjustment specified in Lessor's Notice.

               (e)     Lessee's remedy for any breach of this Paragraph 12.1 by
Lessor shall be limited to compensatory damages and/or injunctive relief.

               (f)     Notwithstanding anything to the contrary contained
herein, Lessee, without first obtaining the consent of Lessor, may assign this
Lease, and Lessee's rights hereunder, to any person, firm, or entity which, or
into which, Lessee may be merged or consolidated, or to which Lessee may sell
all or substantially all of its assets or business, provided that before such
assignment shall be effective, (a) the Net Worth of said Assignee shall be
equal to or higher than that of Lessee as of the date of this Lease (the "Net
Worth Assignee" for purposes of this Lease shall be the net worth of the
proposed assignee established under generally accepted accounting principles
consistently applied), (b) said Assignee shall assume, in full, the obligations
of Lessee under this Lease, and (c) Lessor shall be given written notice of
such assignment and assumption.

       12.2    TERMS AND CONDITIONS APPLICABLE TO ASSIGNMENT AND SUBLETTING.

               (a)     Regardless of Lessor's consent, any assignment or
subletting shall not (i) be effective without the express written assumption by
such assignee or sublessee of the obligations of Lessee under this Lease, (ii)
release Lessee of any obligations hereunder, nor (iii) alter the primary
liability of Lessee for the payment of Base Rent and other sums due Lessor
hereunder or for the performance of any other obligations to be performed by
Lessee under this Lease.

               (b)     Lessor may accept any rent or performance of Lessee's
obligations from any person other than Lessee pending approval or disapproval
of an assignment.  Neither a delay in the approval or disapproval of such
assignment nor the acceptance of any rent for performance shall constitute a
waiver of estoppel of Lessor's right to exercise its remedies for the Default
or Breach by Lessee of any of the terms, covenants or conditions of this
Lease.

               (c)     The consent of Lessor to any assignment or subletting
shall not constitute a consent to any subsequent assignment or subletting by
Lessee or to any subsequent or successive assignment or subletting by the
assignee or sublessee.  However, Lessor may consent to subsequent sublettings
and assignments of the sublease or any amendments or modifications thereto
without notifying Lessee or anyone else liable under this Lease or the sublease
and without obtaining their consent, and such action shall not relieve such
persons from liability under this Lease or the sublease.

               (d)     In the event of any Default or Breach of Lessee's
obligation under this Lease, Lessor may proceed directly against Lessee, any
Guarantors or anyone else responsible for the performance of the Lessee's
obligations under this Lease, including any sublessee, without first exhausting
Lessor's remedies against any other person or entity responsible therefor to
Lessor, or any security held by Lessor.

               (e)     Each request for consent to an assignment or subletting
shall be in writing, accompanied by information relevant to Lessor's
determination as to the financial and operational responsibility and
appropriateness of the proposed assignee or sublessee, including but not limited
to, the intended use and/or required modification of the Premises, if any,
together with a non-refundable deposit of $1,000 or ten percent (10%) of the
monthly Base Rent applicable to the portion of the Premises which is the subject
of the proposed assignment or sublease, whichever is greater, as reasonable
consideration for Lessor's considering and processing the request for consent.
Lessee agrees to provide Lessor with such other or additional information and/or
documentation as may be reasonably requested by Lessor.

               (f)     Any assignee of, or sublessee under, this Lease
shall, by reason of accepting such assignment or entering into such sublease,
be deemed, for the benefit of Lessor, to have assumed and agreed to conform
and comply with each and every term, covenant, condition and obligation
herein to be observed or performed by Lessee during the term of said
assignment or sublease, other than such obligations as are contrary to or
inconsistent with provisions of an assignment or sublease to which Lessor has
specifically consented in writing.

               (g)

               (h)     Lessor, as a condition to giving its consent to any
assignment or subletting, may require that the amount and adjustment schedule
of the rent payable under this Lease be adjusted to what is then the market
value and/or adjustment schedule for property similar to the Premises as then
constituted, as determined by Lessor.

       12.3    ADDITIONAL TERMS AND CONDITIONS APPLICABLE TO SUBLETTING. The
following terms and conditions shall apply to any subletting by Lessee of all
or any part of the Premises and shall be deemed included in all subleases
under this Lease whether or not expressly incorporated therein:

               (a)     Lessee hereby assigns and transfers to Lessor all of
Lessee's interest in all rentals and income arising from any sublease of all
or a portion of the Premises heretofore or hereafter made by Lessee, and
Lessor may collect such rent and income and apply same toward Lessee's
obligations under this Lease; provided, however, that until a Breach (as
defined in Paragraph 13.1) shall occur in the performance of Lessee's
obligations under this Lease, Lessee may, except as otherwise provided in
this Lease, receive, collect and enjoy the rents accruing under such
sublease. Lessor shall not, by reason of the foregoing provision or any other
assignment of such sublease to Lessor, nor by reason of the collection of the
rents from a sublessee, be deemed liable to the sublessee for any failure of
Lessee to perform and comply with any of Lessee's obligations to such
sublessee under such Sublease. Lessee hereby irrevocably authorizes and
directs any such sublessee, upon receipt of a written notice from Lessor
stating that a Breach exists in the performance of Lessee's obligations under
this Lease, to pay to Lessor the rents and other charges due and to become
due under the sublease. Sublessee shall rely upon any such statement and
request from Lessor and shall pay such rents and other charges to Lessor
without any obligation or right to inquire as to whether such Breach exists
and notwithstanding any notice from or claim from Lessee to the contrary.
Lessee shall have no right or claim against such sublessee, or, until the
Breach has been cured, against Lessor, for any such rents and other charges
so paid by said sublessee to Lessor.

               (b)     In the event of a Breach by Lessee in the performance
of its obligations under this Lease, Lessor, at its option and without any
obligation to do so, may require any sublessee to attorn to Lessor, in which
event Lessor shall undertake the obligations of the sublessor under such
sublease from the time of the exercise of said option to the expiration of
such sublease; provided, however, Lessor shall not be liable for any prepaid
rents or security deposit paid by such sublessee to such sublessor or for any
other prior defaults or breaches of such sublessor under such sublease.

               (c)     Any matter or thing requiring the consent of the
sublessor under a sublease shall also require the consent of Lessor herein.

               (d)     No sublessee under a sublease approved by Lessor shall
further assign or sublet all or any part of the Premises without Lessor's
prior written consent.

               (e)     Lessor shall deliver a copy of any notice of Default
or Breach by Lessee to the sublessee, who shall have the right to cure the
Default of Lessee within the grace period, if any, specified in such notice.
The sublessee shall have a right of reimbursement and offset from and against
Lessee for any such Defaults cured by the sublessee.

13.    DEFAULT; BREACH; REMEDIES.

       13.1    DEFAULT; BREACH. Lessor and Lessee agree that if an attorney
is consulted by Lessor in connection with a Lessee Default or Breach (as
hereinafter defined), $350.00 is a reasonable minimum sum per such occurrence
for legal services and costs in the preparation and service of a notice of
Default, and that Lessor may include the cost of such services and costs in
said notice as rent due and payable to sure said default.  A "DEFAULT" by Lessee

                                                           Initials: [ILLEGIBLE]
                                                                     -----------
                                                                          NC
                                                                     -----------
                                 Page 8 of 13

<PAGE>

is defined as a failure by Lessee to observe, comply with or perform
any of the terms, covenants, conditions or rules applicable to Lessee under
this Lease. A "BREACH" by Lessee is defined as the occurrence of any one or
more of the following Defaults, and, where a grace period for cure after
notice is specified herein, the failure by Lessee to cure such Default prior
to the expiration of the applicable grace period, and shall entitle Lessor to
pursue the remedies set forth in Paragraphs 13.2 and/or 13.3:

               (a)     The vacating of the Premises without the intention to
reoccupy same, or the abandonment of the Premises.

               (b)     Except as expressly otherwise provided in this Lease,
the failure by Lessee to make any payment of Base Rent when due, where such
failure continues for three (3) days, or Lessee's failure to make any payment
of Lessee's Share of Common Area Operating Expenses, or any other monetary
payment required to be made by Lessee hereunder as and when due, the failure by
Lessee to provide Lessor with reasonable evidence of insurance or surety bond
required under this Lease, or the failure of Lessee to fulfill any obligation
under this Lease which endangers or threatens life or property, where such
failure continues for a period of three (3) days following written notice
thereof by or on behalf of Lessor to Lessee.

               (c)     Except as expressly otherwise provided in this Lease,
the failure by Lessee to provide Lessor with reasonable written evidence (in
duly executed original form, if applicable) of (i) compliance with Applicable
Requirements per Paragraph 6.3, (ii) the inspection, maintenance and service
contracts required under Paragraph 7.1(b), (iii) the rescission of an
unauthorized assignment or subletting per Paragraph 12.1, (iv) a Tenancy
Statement per Paragraphs 16 or 37, (v) the subordination or non-subordination
of this Lease per Paragraph 30, (vi) the guaranty of the performance of
Lessee's obligations under this Lease if required under Paragraphs 1.11 and
37, (vii) the execution of any document requested under Paragraph 42
(easements), or (viii) any other documentation or information which Lessor
may reasonably require of Lessee under the terms of this Lease, where any
such failure continues for a period of ten (10) days following written notice
by or on behalf of Lessor to Lessee.

               (d)     A Default by Lessee as to the terms, covenants,
conditions or provisions of this Lease, or of the rules adopted under
Paragraph 40 hereof that are to be observed, complied with or performed by
Lessee, other than those described in Subparagraphs 13.1(a), (b) or (c),
above, where such Default continues for a period of thirty (30) days after
written notice thereof by or on behalf of Lessor to Lessee; provided,
however, that if the nature of Lessee's Default is such that more than thirty
(30) days are reasonably required for its cure, then it shall not be deemed
to be a Breach of this Lease by Lessee if Lessee commences such cure within
said thirty (30) day period and thereafter diligently prosecutes such cure to
completion.

               (e)     The occurrence of any of the following events: (i) the
making by Lessee of any general arrangement or assignment for the benefit of
creditors; (ii) Lessee's becoming a "debtor" as defined in 11 U.S. Code
Section 101 or any successor statute thereto (unless, in the case of a
petition filed against Lessee, the same is dismissed within sixty (60) days);
(iii) the appointment of a trustee or receiver to take possession of
substantially all of Lessee's assets located at the Premises or of Lessee's
interest in this Lease, where possession is not restored to Lessee within
thirty (30) days; or (iv) the attachment, execution or other judicial seizure
of substantially all of Lessee's assets located at the Premises or of Lessee's
interest in this Lease, where such seizure is not discharged within thirty
(30) days; provided, however, in the event that any provision of this
Subparagraph 13.1(e) is contrary to any applicable law, such provision shall
be of no force or effect, and shall not affect the validity of the remaining
provisions.

               (f)     The discovery by Lessor that any financial statement
of Lessee or of any Guarantor, given to Lessor by Lessee or any Guarantor,
was materially false.

               (g)     If the performance of Lessee's obligations under this
Lease is guaranteed: (i) the death of a Guarantor, (ii) the termination of a
Guarantor's liability with respect to this Lease other than in accordance
with the terms of such guaranty, (iii) a Guarantor's becoming insolvent or
the subject of a bankruptcy filing, (iv) a Guarantor's refusal to honor the
guaranty, or (v) a Guarantor's breach of its guaranty obligation on an
anticipatory breach basis, and Lessee's failure, within sixty (60) days
following written notice by or on behalf of Lessor to Lessee of any such
event, to provide Lessor with written alternative assurances of security,
which, when coupled with the then existing resources of Lessee, equals or
exceeds the combined financial resources of Lessee and the Guarantors that
existed at the time of execution of this Lease.

       13.2    REMEDIES. If Lessee fails to perform any affirmative duty or
obligation of Lessee under this Lease, within ten (10) days after written
notice to Lessee (or in case of an emergency, without notice), Lessor may at
its option (but without obligation to do so), perform such duty or obligation
on Lessee's behalf, including, but not limited to, the obtaining of reasonably
required bonds, insurance policies, or governmental licenses, permits or
approvals. The costs and expenses of any such performance by Lessor shall be
due and payable by Lessee to Lessor upon invoice therefor. If any check given
to Lessor by Lessee shall not be honored by the bank upon which it is drawn,
Lessor, at its own option, may require all future payments to be made under
this Lease by Lessee to be made only by cashier's check. In the event of a
Breach of this Lease by Lessee (as defined in Paragraph 13.1), with or
without further notice or demand, and without limiting Lessor in the exercise
of any right or remedy which Lessor may have by reason of such Breach, Lessor
may:

               (a)     Terminate Lessee's right to possession of the Premises
by any lawful means, in which case this Lease and the term hereof shall
terminate and Lessee shall immediately surrender possession of the Premises
to Lessor. In such event Lessor shall be entitled to recover from Lessee: (i)
the worth at the time of the award of the unpaid rent which had been earned
at the time of termination; (ii) the worth at the time of award of the amount
by which the unpaid rent which would have been earned after termination until
the time of award exceeds the amount of such rental loss that the Lessee
proves could have been reasonably avoided; (iii) the worth at the time of
award of the amount by which the unpaid rent for the balance of the term
after the time of award exceeds the amount of such rental loss that the
Lessee proves could be reasonably avoided; and (iv) any other amount
necessary to compensate Lessor for all the detriment proximately caused by
the Lessee's failure to perform its obligations under this Lease or which in
the ordinary course of things would be likely to result therefrom, including,
but not limited to, the cost of recovering possession of the Premises,
expenses of reletting, including necessary renovation and alteration of the
Premises, reasonable attorneys' fees, and that portion of any leasing
commission paid by Lessor in connection with this Lease applicable to the
unexpired term of this Lease. The worth at the time of award of the amount
referred to in provision (iii) of the immediately preceding sentence shall be
computed by discounting such amount at the discount rate of the Federal
Reserve Bank of San Francisco or the Federal Reserve Bank District in which
the Premises are located at the time of award plus one percent (1%). Efforts
by Lessor to mitigate damages caused by Lessee's Default or Breach of this
Lease shall not waive Lessor's right to recover damages under this Paragraph
13.2. If termination of this Lease is obtained through the provisional remedy
of unlawful detainer, Lessor shall have the right to recover in such
proceeding the unpaid rent and damages as are recoverable therein, or Lessor
may reserve the right to recover all or any part thereof in a separate suit
for such rent and/or damages. If a notice and grace period required under
Subparagraphs 13.1(b), (c) or (d) was not previously given, a notice to pay
rent or quit, or to perform or quit, as the case may be, given to Lessee
under any statute authorizing the forfeiture of leases for unlawful detainer
shall also constitute the applicable notice for grace period purposes
required by Subparagraph 13.1(b), (c) or (d). In such case, the applicable
grace period under the unlawful detainer statute shall run concurrently after
the one such statutory notice, and the failure of Lessee to cure the Default
within the greater of the two (2) such grace periods shall constitute both an
unlawful detainer and a Breach of this Lease entitling Lessor to the remedies
provided for in this Lease and/or by said statute.

               (b)     Continue the Lease and Lessee's right to possession in
effect (in California under California Civil Code Section 1951.4) after
Lessee's Breach and recover the rent as it becomes due, provided Lessee has
the right to sublet or assign, subject only to reasonable limitations. Lessor
and Lessee agree that the limitations on assignment and subletting in this
Lease are reasonable. Acts of maintenance or preservation, efforts to relet
the Premises, or the appointment of a receiver to protect the Lessor's
interest under this Lease, shall not constitute a termination of the Lessee's
right to possession.

               (c)     Pursue any other remedy now or hereafter available to
Lessor under the laws or judicial decisions of the state wherein the Premises
are located.

               (d)     The expiration or termination of this Lease and/or the
termination of Lessee's right to possession shall not relieve Lessee from
liability under any indemnity provisions of this Lease as to matters
occurring or accruing during the term hereof or by reason of Lessee's
occupancy of the Premises.

       13.3

       13.4    LATE CHARGES. Lessee hereby acknowledges that late payment by
Lessee to Lessor of rent and other sums due hereunder will cause Lessor to
incur costs not contemplated by this Lease, the exact amount of which will be
extremely difficult to ascertain. Such costs include, but are not limited to,
processing and accounting charges, and late charges which may be imposed upon
Lessor by the terms of any ground lease, mortgage or deed of trust

                                                           INITIALS: [ILLEGIBLE]
                                                                     -----------
                                                                          NC
                                                                     -----------
                                 Page 9 of 13
<PAGE>

covering the Premises. Accordingly, if any installment of rent or other sum due
from Lessee shall not be received by Lessor or Lessor's designee within ten
(10) days after such amount shall be due, then, without any requirement for
notice to Lessee, Lessee shall pay to Lessor a late charge equal to six percent
(6%) of such overdue amount. The Parties hereby agree that such late charge
represents a fair and reasonable estimate of the costs Lessor will incur by
reason of late payment by Lessee. Acceptance of such late charge by Lessor
shall in no event constitute a waiver of Lessee's Default or Breach with
respect to such overdue amount, nor prevent Lessor from exercising any of the
other rights and remedies granted hereunder. In the event that a late charge is
payable hereunder, whether or not collected, for three (3) consecutive
installments of Base Rent, then notwithstanding Paragraph 4.1 or any other
provision of this Lease to the contrary, Base Rent shall, at Lessor's option,
become due and payable quarterly in advance.

       13.5    BREACH BY LESSOR. Lessor shall not be deemed in breach of this
Lease unless Lessor fails within a reasonable time to perform an obligation
required to be performed by Lessor. For purposes of this Paragraph 13.5, a
reasonable time shall in no event be less than thirty (30) days after receipt
by Lessor, and by any Lender(s) whose name and address shall have been
furnished to Lessee in writing for such purpose, of written notice specifying
wherein such obligation of Lessor has not been performed; provided, however,
that if the nature of Lessor's obligation is such that more than thirty (30)
days after such notice are reasonably required for its performance, then
Lessor shall not be in breach of this Lease if performance is commenced
within such thirty (30) day period and thereafter diligently pursued to
completion.

14.    CONDEMNATION. If the Premises or any portion thereof are taken under
the power of eminent domain or sold under the threat of the exercise of said
power (all of which are herein called "condemnation"), this Lease shall
terminate as to the part so taken as of the date the condemning authority
takes title or possession, whichever first occurs. If more than ten percent
(10%) of the floor area of the Premises, or more than twenty-five percent
(25%) of the portion of the Common Areas designated for Lessee's parking, is
taken by condemnation, Lessee may, at Lessee's option, to be exercised in
writing within ten (10) days after Lessor shall have given Lessee written
notice of such taking (or in the absence of such notice, within ten (10) days
after the condemning authority shall have taken possession) terminate this
Lease as of the date the condemning authority takes such possession. If
Lessee does not terminate this Lease in accordance with the foregoing, this
Lease shall remain in full force and effect as to the portion of the Premises
remaining, except that the Base Rent shall be reduced in the same proportion
as the rentable floor area of the Premises taken bears to the total rentable
floor area of the Premises. No reduction of Base Rent shall occur if the
condemnation does not apply to any portion of the Premises. Any award for the
taking of all or any part of the Premises under the power of eminent domain
or any payment made under threat of the exercise of such power shall be the
property of Lessor, whether such award shall be made as compensation for
diminution of value of the leasehold or for the taking of the fee, or as
severance damages; provided, however, that Lessee shall be entitled to any
compensation, separately awarded to Lessee for Lessee's relocation expenses
and/or loss of Lessee's Trade Fixtures. In the event that this Lease is not
terminated by reason of such condemnation, Lessor shall to the extent of its
net severance damages received, over and above Lessee's share of the legal
and other expenses incurred by Lessor in the condemnation matter, repair any
damage to the Premises caused by such condemnation authority. Lessee shall be
responsible for the payment of any amount in excess of such net severance
damages required to complete such repair.

15.    BROKERS' FEES.

       15.1

       15.2

       15.3

       15.4    REPRESENTATIONS AND WARRANTIES. Lessee and Lessor each
represent and warrant to the other that it has had no dealings with any
person, firm, broker or finder other than as named in Paragraph 1.10(a) in
connection with the negotiation of this Lease and/or the consummation of the
transaction contemplated hereby, and that no broker or other person, firm or
entity other than said named Broker(s) is entitled to any commission or
finder's fee in connection with said transaction. Lessee and Lessor do each
hereby agree to indemnify, protect, defend and hold the other harmless from
and against liability for compensation or charges which may be claimed by any
such unnamed broker, finder or other similar party by reason of any dealings
or actions of the indemnifying Party, including any costs, expenses, and/or
attorneys' fees reasonably incurred with respect thereto.

16.    TENANCY AND FINANCIAL STATEMENTS.

       16.1    TENANCY STATEMENT. Upon 10 days notice from Lessor, Lessee shall
execute and deliver to Lessor, in a form reasonably requested by Lessor, a
Tenant Estoppel Certificate acknowledging that the Lease is in full force and
effect, describing any amendments or modifications hereto, acknowledging that
this Lease is subordinate or prior, as the case may be, to any encumbrance and
stating any other information Lessor may reasonably request, including the term
of this Lease, the base rent, the estimated operating costs, the date to which
rent has been paid, the amount of security deposit or prepaid rent, and other
such information reasonably requested by Lessor.  Lessor's failure to deliver
such a statement shall be default under the Lease and shall be conclusive upon
Lessee, that the Lease is in full force and effect, that there are no uncured
defaults of Landlord and that no more than one month's rent has been paid in
advance.

       16.2    FINANCIAL STATEMENT. If Lessor desires to finance, refinance,
or sell the Premises or the Building, or any part thereof, Lessee and all
Guarantors shall deliver to any potential lender or purchaser designated by
Lessor such financial statements of Lessee and such Guarantors as may be
reasonably required by such lender or purchaser, including, but not limited
to, Lessee's financial statements for the past three (3) years. All such
financial statements shall be received by Lessor and such lender or purchaser
in confidence and shall be used only for the purposes herein set forth.

17.    LESSOR'S LIABILITY. The term "LESSOR" as used herein shall mean the
owner or owners at the time in question of the fee title to the Premises. In
the event of a transfer of Lessor's title or interest in the Premises or in
this Lease, Lessor shall deliver to the transferee or assignee (in cash or by
credit) any unused Security Deposit held by Lessor at the time of such
transfer or assignment. Except as provided in Paragraph 15.3, upon such
transfer or assignment and delivery of the Security Deposit, as aforesaid,
the prior Lessor shall be relieved of all liability with respect to the
obligations and/or covenants under this Lease thereafter to be performed by
the Lessor. Subject to the foregoing, the obligations and/or covenants in
this Lease to be performed by the Lessor shall be binding only upon the
Lessor as hereinabove defined.

18.    SEVERABILITY. The invalidity of any provision of this Lease, as
determined by a court of competent jurisdiction, shall in no way affect the
validity of any other provision hereof.

19.    INTEREST ON PAST-DUE OBLIGATIONS. Any monetary payment due Lessor
hereunder, other than late charges, not received by Lessor within ten (10)
days following the date on which it was due, shall bear interest from the
date due at the prime rate charged by the largest state chartered bank in the
state in which the Premises are located plus four percent (4%) per annum, but
not exceeding the maximum rate allowed by law, in addition to the potential
late charge provided for in Paragraph 13.4.

20.    TIME OF ESSENCE. Time is of the essence with respect to the
performance of all obligations to be performed or observed by the Parties
under this Lease.

21.    RENT DEFINED. All monetary obligations of Lessee to Lessor under the
terms of this Lease are deemed to be rent.

22.    NO PRIOR OR OTHER AGREEMENTS; BROKER DISCLAIMER. This Lease contains
all agreements between the Parties with respect to any matter mentioned
herein, and no other prior or contemporaneous agreement or understanding
shall be effective. Lessor and Lessee each represents and warrants to the
Brokers that it has made, and is relying solely upon, its own investigation
as to the nature, quality, character and financial responsibility of the
other Party to this Lease and as to the nature, quality and character of the
Premises. Brokers have no responsibility with respect thereto or with respect
to any default or breach hereof by either Party. Each Broker shall be an
intended third party beneficiary of the provisions of this Paragraph 22.

23.    NOTICES.

       23.1    NOTICE REQUIREMENTS. All notices required or permitted by this
Lease shall be in writing and may be delivered in person (by hand or by
messenger or courier service) or may be sent by regular, certified or
registered mail or U.S. Postal Service Express Mail, with postage prepaid, or
by facsimile transmission during normal business hours, and shall be deemed
sufficiently given if served in a manner specified in this Paragraph 23. The
addresses noted

                                                           INITIALS: [ILLEGIBLE]
                                                                     -----------
                                                                          NC
                                                                     -----------
                                Page 10 of 13

<PAGE>

adjacent to a Party's signature on this Lease shall be that Party's address
for delivery or mailing of notice purposes. Either Party may by written
notice to the other specify a different address for notice purposes, except
that upon Lessee's taking possession of the Premises, the Premises shall
constitute Lessee's address for the purpose of mailing or delivering notices
to Lessee. A copy of all notices required or permitted to be given to Lessor
hereunder shall be concurrently transmitted to such party or parties at such
addresses as Lessor may from time to time hereafter designate by written
notice to Lessee.

       23.2    DATE OF NOTICE. Any notice sent by registered or certified
mail, return receipt requested, shall be deemed given on the date of delivery
shown on the receipt card, or if no delivery date is shown, the postmark
thereon. If sent by regular mail, the notice shall be deemed given
forty-eight (48) hours after the same is addressed as required herein and
mailed with postage prepaid. Notices delivered by United States Express Mail
or overnight courier that guarantees next day delivery shall be deemed given
twenty-four (24) hours after delivery of the same to the United States Postal
Service or courier. If any notice is transmitted by facsimile transmission or
similar means, the same shall be deemed served or delivered upon telephone or
facsimile confirmation of receipt of the transmission thereof, provided a
copy is also delivered via delivery or mail. If notice is received on a
Saturday or a Sunday or a legal holiday, it shall be deemed received on the
next business day.

24.    WAIVERS. No waiver by Lessor of the Default or Breach of any term,
covenant or condition hereof by Lessee, shall be deemed a waiver of any other
term, covenant or condition hereof, or of any subsequent Default or Breach by
Lessee of the same or any other term, covenant or condition hereof. Lessor's
consent to, or approval of, any such act shall not be deemed to render
unnecessary the obtaining of Lessor's consent to, or approval of, any
subsequent or similar act by Lessee, or be construed as the basis of an
estoppel to enforce the provision or provisions of this Lease requiring such
consent. Regardless of Lessor's knowledge of a Default or Breach at the time
of accepting rent, the acceptance of rent by Lessor shall not be a waiver of
any Default or Breach by Lessee of any provision hereof. Any payment given
Lessor by Lessee may be accepted by Lessor on account of monies or damages
due Lessor, notwithstanding any qualifying statements or conditions made by
Lessee in connection therewith, which such statements and/or conditions shall
be of no force or effect whatsoever unless specifically agreed to in writing
by Lessor at or before the time of deposit of such payment.

25.

26.    NO RIGHT TO HOLDOVER. Lessee has no right to retain possession of the
Premises or any part thereof beyond the expiration or earlier termination of
this Lease. In the event that Lessee holds over in violation of this
Paragraph 26 then the Base Rent payable from and after the time of the
expiration or earlier termination of this Lease shall be increased to two
hundred percent (200%) of the Base Rent applicable during the month
immediately preceding such expiration or earlier termination.  Nothing
contained herein shall be construed as a consent by Lessor to any holding
over by Lessee.

27.    CUMULATIVE REMEDIES. No remedy or election hereunder shall be deemed
exclusive but shall, wherever possible, be cumulative with all other remedies
at law or in equity.

28.    COVENANTS AND CONDITIONS. All provisions of this Lease to be observed
or performed by Lessee are both covenants and conditions.

29.    BINDING EFFECT; CHOICE OF LAW. This Lease shall be binding upon the
Parties, their personal representatives, successors and assigns and be
governed by the laws of the state in which the Premises are located. Any
litigation between the Parties hereto concerning this Lease shall be
initiated in the county in which the Premises are located.

30.    SUBORDINATION; ATTORNMENT; NON-DISTURBANCE.

       30.1    SUBORDINATION. This Lease and any Option granted hereby shall
be subject and subordinate to any ground lease, mortgage, deed of trust, or
other hypothecation or security device (collectively, "SECURITY DEVICE"), now
or hereafter placed by Lessor upon the real property of which the Premises
are a part, to any and all advances made on the security thereof, and to all
renewals, modifications, consolidations, replacements and extensions thereof.
Lessee agrees that the Lenders holding any such Security Device shall have no
duty, liability or obligation to perform any of the obligations of Lessor
under this Lease, but that in the event of Lessor's default with respect to
any such obligation, Lessee will give any Lender whose name and address have
been furnished Lessee in writing for such purpose notice of Lessor's default
pursuant to Paragraph 13.5. If any Lender shall elect to have this Lease
and/or any Option granted hereby superior to the lien of its Security Device
and shall give written notice thereof to Lessee, this Lease and such Options
shall be deemed prior to such Security Device, notwithstanding the relative
dates of the documentation or recordation thereof.

       30.2    ATTORNMENT. Subject to the non-disturbance provisions of
Paragraph 30.3, Lessee agrees to attorn to a Lender or any other party who
acquires ownership of the Premises by reason of a foreclosure of a Security
Device, and that in the event of such foreclosure, such new owner shall not:
(i) be liable for any act or omission of any prior lessor or with respect to
events occurring prior to acquisition of ownership, (ii) be subject to any
offsets or defenses which Lessee might have against any prior lessor, or
(iii) be bound by prepayment of more than one (1) month's rent.

       30.3    NON-DISTURBANCE. With respect to Security Devices entered into
by Lessor after the execution of this Lease, Lessor shall make commercially
reasonable efforts to obtain, on behalf of Lessee, assurance (a
"non-disturbance agreement") from the Lender that Lessee's possession and
this Lease, including any options to extend the term hereof, will not be
disturbed so long as Lessee is not in Breach hereof and attorns to the record
owner of the Premises.

       30.4    SELF-EXECUTING. The agreements contained in this Paragraph 30
shall be effective without the execution of any further documents; provided,
however, that upon written request from Lessor or a Lender in connection with
a sale, financing or refinancing of Premises, Lessee and Lessor shall execute
such further writings as may be reasonably required to separately document
any such subordination or non-subordination, attornment and/or
non-disturbance agreement as is provided for herein.

31.    ATTORNEYS' FEES. If any Party or Broker brings an action or
proceeding to enforce the terms hereof or declare rights hereunder, the
Prevailing Party (as hereafter defined) in any such proceeding, action, or
appeal thereon, shall be entitled to reasonable attorneys' fees. Such fees may
be awarded in the same suit or recovered in a separate suit, whether or not
such action or proceeding is pursued to decision or judgment. The term
"PREVAILING PARTY" shall include, without limitation, a Party or Broker who
substantially obtains or defeats the relief sought, as the case may be,
whether by compromise, settlement, judgment, or the abandonment by the other
Party or Broker of its claim or defense. The attorneys' fee award shall not
be computed in accordance with any court fee schedule, but shall be such as to
fully reimburse all attorneys' fees reasonably incurred. Lessor shall be
entitled to attorneys' fees, costs and expenses incurred in preparation and
service of notices of Default and consultations in connection therewith,
whether or not a legal action is subsequently commenced in connection with
such Default or resulting Breach. Broker(s) shall be intended third party
beneficiaries of this Paragraph 31.

32.    LESSOR'S ACCESS; SHOWING PREMISES; REPAIRS. Lessor and Lessor's
agents shall have the right to enter the Premises at any time, in the case of
an emergency, and otherwise at reasonable times for the purpose of showing
the same to prospective purchasers, lenders, or lessees, and making such
alterations, repairs, improvements or additions to the Premises or to the
Building, as Lessor may reasonably deem necessary. Lessor may at any time
place on or about the Premises or Building any ordinary "For Sale" signs and
Lessor may at any time during the last one hundred eighty (180) days of the
term hereof place on or about the Premises any ordinary "For Lease" signs.
All such activities of Lessor shall be without abatement of Rent or liability
to Lessee.

33.    AUCTIONS. Lessee shall not conduct, nor permit to be conducted,
either voluntarily or involuntarily, any auction upon the Premises without
first having obtained Lessor's prior written consent. Notwithstanding
anything to the contrary in this Lease, Lessor shall not be obligated to
exercise any standard of reasonableness in determining whether to grant such
consent.

34.    SIGNS. Lessee shall not place any sign upon the exterior of the
Premises or the Building, except that Lessee may, with Lessor's prior written
consent, install (but not on the roof) such signs as are reasonably required
to advertise Lessee's own business so long as such signs are in a location
designated by Lessor and comply with Applicable Requirements and the signage
criteria established for the Industrial Center by Lessor. The installation of
any sign on the Premises by or for Lessee shall be subject to the provisions of
Paragraph 7 (Maintenance, Repairs, Utility Installations, Trade Fixtures and
Alterations). Unless otherwise expressly agreed herein, Lessor reserves all
rights to the use of the roof of the Building, and the right to install
advertising signs on the Building, including the roof, which do not
unreasonably interfere with the conduct of Lessee's business; Lessor shall be
entitled to all revenues from such advertising signs.

35.    TERMINATION; MERGER. Unless specifically stated otherwise in writing
by Lessor, the voluntary or other surrender of this Lease by Lessee, the mutual
termination or cancellation hereof, or a termination hereof by Lessor for
Breach by Lessee, shall automatically terminate any sublease or lesser estate
in the Premises; provided, however, Lessor shall, in the event of any such
surrender, termination or cancellation, have the option to continue any one
or all of any existing subtenancies. Lessor's failure within ten (10) days
following any such event to make a written election to the contrary by
written notice to the holder of any such lesser interest, shall constitute
Lessor's election to have such event constitute the termination of such
interest.

36.    CONSENTS.

               (a)    Except for Paragraph 33 hereof (Auctions) or as
otherwise provided herein, wherever in this Lease the consent of a Party is
required to an act by or for the other Party, such consent shall not be
unreasonably withheld or delayed. Lessor's actual reasonable costs and
expenses (including, but not limited to, architects', attorneys', engineers'
and other consultants' fees) incurred in the consideration of, or response
to, a request by Lessee for any Lessor consent pertaining to this Lease or
the Premises, including, but not limited to, consents to an assignment, a
subletting or the presence or use of a Hazardous

                                                          INITIALS:  [ILLEGIBLE]
                                                                        -----
                                                                         NC
                                                                        -----
                                 Page 11 of 13

<PAGE>

Substance, shall be paid by Lessee to Lessor upon receipt of an invoice and
supporting documentation therefor. In addition to the deposit described in
Paragraph 12.2(e), Lessor may, as a condition to considering any such request
by Lessee, require that Lessee deposit with Lessor an amount of money (in
addition to the Security Deposit held under Paragraph 5) reasonably
calculated by Lessor to represent the cost Lessor will incur in considering
and responding to Lessee's request. Any unused portion of said deposit shall
be refunded to Lessee without interest. Lessor's consent to any act,
assignment of this Lease or subletting of the Premises by Lessee shall not
constitute an acknowledgement that no Default or Breach by Lessee of this
Lease exists, nor shall such consent be deemed a waiver of any then existing
Default or Breach, except as may be otherwise specifically stated in writing
by Lessor at the time of such consent.

               (b)    All conditions to Lessor's consent authorized by this
Lease are acknowledged by Lessee as being reasonable. The failure to specify
herein any particular condition to Lessor's consent shall not preclude the
impositions by Lessor at the time of consent of such further or other
conditions as are then reasonable with reference to the particular matter for
which consent is being given.

37.    GUARANTOR.

       37.1    FORM OF GUARANTY. If there are to be any Guarantors of this
Lease per Paragraph 1.11, the form of the guaranty to be executed by each
such Guarantor shall be in the form most recently published by the American
Industrial Real Estate Association, and each such Guarantor shall have the
same obligations as Lessee under this Lease, including, but not limited to,
the obligation to provide the Tenancy Statement and information required in
Paragraph 16.

        37.2   ADDITIONAL OBLIGATIONS OF GUARANTOR. It shall constitute a
Default of the Lessee under this Lease if any such Guarantor fails or
refuses, upon reasonable request by Lessor to give: (a) evidence of the due
execution of the guaranty called for by this Lease, including the authority
of the Guarantor (and of the party signing on Guarantor's behalf) to obligate
such Guarantor on said guaranty, and resolution of its board of directors
authorizing the making of such guaranty, together with a certificate of
incumbency showing the signatures of the persons authorized to sign on its
behalf, (b) current financial statements of Guarantor as may from time to
time be requested by Lessor, (c) a Tenancy Statement, or (d) written
confirmation that the guaranty is still in effect.

38.    QUIET POSSESSION. Upon payment by Lessee of the Rent for the
Premises and the performance of all of the covenants, conditions and
provisions on Lessee's part to be observed and performed under this Lease,
Lessee shall have quiet possession of the Premises for the entire term hereof
subject to all of the provisions of this Lease.

39.

       39.1

       39.2

       39.3

       39.4

40.    RULES AND REGULATIONS. Lessee agrees that it will abide by, and keep
and observe all reasonable rules and regulations ("RULES AND REGULATIONS")
which Lessor may make from time to time for the management, safety, care, and
cleanliness of the grounds, the parking and unloading of vehicles and the
preservation of good order, as well as for the convenience of other
occupants or tenants of the Building and the Industrial Center and their
invitees.

41.    SECURITY MEASURES. Lessee hereby acknowledges that the rental
payable to Lessor hereunder does not include the cost of guard service or
other security measures, and that Lessor shall have no obligation whatsoever
to provide same. Lessee assumes all responsibility for the protection of the
Premises, Lessee, its agents and invitees and their property from the acts of
third parties.

42.    RESERVATIONS. Lessor reserves the right, from time to time, to
grant, without the consent or joinder of Lessee, such easements, rights of
way, utility raceways, and dedications that Lessor deems necessary, and to
cause the recordation of parcel maps and restrictions, so long as such
easements, rights of way, utility raceways, dedications, maps and
restrictions do not reasonably interfere with the use of the Premises by
Lessee. Lessee agrees to sign any documents reasonably requested by Lessor to
effectuate any such easement rights, dedication, map or restrictions.

43.    PERFORMANCE UNDER PROTEST. If at any time a dispute shall arise as to
any amount or sum of money to be paid by one Party to the other under the
provisions hereof, the Party against whom the obligation to pay the money is
asserted shall have the right to make payment "under protest" and such
payment shall not be regarded as a voluntary payment and there shall survive
the right on the part of said Party to institute suit for recovery of such
sum. If it shall be adjudged that there was no legal obligation on the part
of said Party to pay such sum or any part thereof, said Party shall be
entitled to recover such sum or so much thereof as it was not legally
required to pay under the provisions of this Lease.

44.    AUTHORITY. If either Party is a corporation, trust, or general or
limited partnership, each individual executing this Lease on behalf of such
entity represents and warrants that he or she is duly authorized to execute
and deliver this Lease on its behalf. If Lessee is a corporation, trust or
partnership, Lessee shall, within thirty (30) days after request by Lessor,
deliver to Lessor evidence satisfactory to Lessor of such authority.

45.    CONFLICT. Any conflict between the printed provisions of this Lease
and the typewritten or handwritten provisions shall be controlled by the
typewritten or handwritten provisions.

46.    OFFER. Preparation of this Lease by either Lessor or Lessee or
Lessor's agent or Lessee's agent and submission of same to Lessee or Lessor
shall not be deemed an offer to lease. This Lease is not intended to be
binding until executed and delivered by all Parties hereto.

47.    AMENDMENTS. This Lease may be modified only in writing, signed by
the Parties in interest at the time of the modification. The Parties shall
amend this Lease from time to time to reflect any adjustments that are made
to the Base Rent or other rent payable under this Lease. As long as they do
not materially change Lessee's obligations hereunder, Lessee agrees to make
such reasonable non-monetary modifications to this Lease as may be reasonably
required by an institutional insurance company or pension plan Lender in
connection with the obtaining of normal financing or refinancing of the
property of which the Premises are a part.

48.    MULTIPLE PARTIES. Except as otherwise expressly provided herein, if
more than one person or entity is named herein as either Lessor or Lessee,
the obligations of such multiple parties shall be the joint and several
responsibility of all persons or entities named herein as such Lessor or
Lessee.

LESSOR AND LESSEE HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM
AND PROVISION CONTAINED HEREIN, AND BY THE EXECUTION OF THIS LEASE SHOW THEIR
INFORMED AND VOLUNTARY CONSENT THERETO.  THE PARTIES HEREBY AGREE THAT, AT THE
TIME THIS LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE COMMERCIALLY
REASONABLE AND EFFECTUATE THE INTENT AND

                                                          INITIALS:  [ILLEGIBLE]
                                                                        -----
                                                                         NC
                                                                        -----
                                 Page 12 of 13
<PAGE>

PURPOSE OF LESSOR AND LESSEE WITH RESPECT TO THE PREMISES.

     IF THIS LEASE HAS BEEN FILLED IN, IT HAS BEEN PREPARED FOR YOUR
     ATTORNEY'S REVIEW AND APPROVAL. FURTHER, EXPERTS SHOULD BE CONSULTED TO
     EVALUATE THE CONDITION OF THE PROPERTY FOR THE POSSIBLE PRESENCE OF
     ASBESTOS, UNDERGROUND STORAGE TANKS OR HAZARDOUS SUBSTANCES. NO
     REPRESENTATION OR RECOMMENDATION IS MADE BY THE AMERICAN INDUSTRIAL REAL
     ESTATE ASSOCIATION OR BY THE REAL ESTATE BROKERS OR THEIR CONTRACTORS,
     AGENTS OR EMPLOYEES AS TO THE LEGAL SUFFICIENCY, LEGAL EFFECT, OR TAX
     CONSEQUENCES OF THIS LEASE OR THE TRANSACTION TO WHICH IT RELATES; THE
     PARTIES SHALL RELY SOLELY UPON THE ADVICE OF THEIR OWN COUNSEL AS TO THE
     LEGAL AND TAX CONSEQUENCES OF THIS LEASE. IF THE SUBJECT PROPERTY IS IN
     A STATE OTHER THAN CALIFORNIA, AN ATTORNEY FROM THE STATE WHERE THE
     PROPERTY IS LOCATED SHOULD BE CONSULTED.

The Parties hereto have executed this Lease at the place and on the dates
specified above their respective signatures.

Executed at: San Diego, California     Executed at: San Diego, California
            -------------------------              ---------------------------

on:  April   , 2000                    on:  April 21, 2000
   ----------------------------------      -----------------------------------

BY LESSOR:                             BY LESSEE:
SORRENTO WEST PARTNERS, L.P.,          ELITRA PHARMACEUTICALS, INC.,
-------------------------------------  -------------------------------------
A California limited partnership       a Delaware corporation
-------------------------------------  -------------------------------------

By:                                    By:  /s/ Harry Hixson
   ----------------------------------      -----------------------------------

Name Printed: (See Attached Lessor     Name Printed: Harry Hixson
              Signature Page
             ------------------------               --------------------------

Title:                                 Title:  CEO
      -------------------------------         --------------------------------

By:                                    By:  /s/ Greg Tibbets
   ----------------------------------      -----------------------------------

Name Printed:                          Name Printed: Greg Tibbets
             ------------------------               --------------------------

Title:                                 Title:  Director of Finance
      -------------------------------         --------------------------------

Address:                               Address: 3510 Dunhill St
        -----------------------------           ------------------------------
                                                San Diego, CA 92121
-------------------------------------  ---------------------------------------

Telephone: (   )                       Telephone: (858) 410 3030
            --- ---------------------              --- -----------------------

Facsimile: (   )                       Facsimile: (858) 410 3090
            --- ---------------------              --- -----------------------

BROKER:                                BROKER:

Executed at:                           Executed at:
            -------------------------              ---------------------------

on:                                    on:
   ----------------------------------      -----------------------------------

By:                                    By:
   ----------------------------------      -----------------------------------

Name Printed:                          Name Printed:
             ------------------------               --------------------------

Title:                                 Title:
      -------------------------------         --------------------------------

Address:                               Address:
        -----------------------------           ------------------------------

-------------------------------------  ---------------------------------------

Telephone: (   )                       Telephone: (   )
            --- ---------------------              --- -----------------------

Facsimile: (   )                       Facsimile: (   )
            --- ---------------------              --- -----------------------

NOTE: These forms are often modified to meet changing requirements of law and
      needs of the industry. Always write or call to make sure you are
      utilizing the most current form: AMERICAN INDUSTRIAL REAL ESTATE
      ASSOCIATION, 700 South Flower Street, Suite 600, Los Angeles,
      California 90017  (213) 687-8777.

                                                     Initials: GT
                                                               --
                                                               NC
                                                               --

                                Page 13 of 13
<PAGE>

LEASE AGREEMENT: PAGE 13-1
------------------------------

SORRENTO WEST PARTNERS, L.P.,
A California limited partnership

By: Barrow Street Gliders, LLC,
    a Delaware limited liability company
    Its General Partner

    By: Barrow Street Real Estate Fund L.P.,
        a Delaware limited partnership
        Its Sole Member

        By: Barrow Street Capital LLC,
            a Delaware limited liability company
            Its General Partner

            By: Barrow Street Partners, LLC,
                a Delaware limited liability company
                Its Managing Member

                By:  /s/ Nicholas Chermayoff
                   --------------------------------------------------
                Name:  Nicholas Chermayoff
                     ------------------------------------------------
                Title: Member

<PAGE>

                                  ADDENDUM TO
                STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE

     THIS ADDENDUM TO STANDARD INDUSTRIAL/COMMERCIAL MULTI-TENANT LEASE
("Addendum") is made and entered into by and between SORRENTO WEST PARTNERS,
L.P., a California limited partnership ("Lessor"), and ELITRA
PHARMACEUTICALS, INC., a Delaware corporation ("Lessee"), as of the date set
forth on the first page of that certain Standard Industrial/Commercial
Multi-Tenant Lease (the "Lease") between Lessor and Lessee to which this
Addendum is attached and incorporated. The terms, covenants and conditions
set forth herein are intended to and shall have the same force and effect as
if set forth at length in the body of the Lease. To the extent that the
provisions of this Addendum are inconsistent with any provisions of the
Lease, the provisions of this Addendum shall supersede and control.

49.  OCCUPANCY OF PREMISES.

     Lessee may occupy Suite D of the Premises immediately upon execution of
     this Lease. Lessee may occupy Suites A, B and C of the Premises upon
     substantial completion of the Tenant Improvements by Lessor, and receipt
     of a certificate of occupancy (or comparable "right to occupy") from the
     City of San Diego pursuant to Paragraph 51 of this Addendum.

50.  PAYMENT OF BASE RENT AND OPERATING EXPENSES.

     (a)  Lessee shall pay Base Rent and Lessee's Share of Common Area
          Operating Expenses and Real Property Taxes for Suite D commencing
          upon execution of this Lease, in proportion that the rentable area
          of Suite D bears to the entire rentable area of the Premises.

     (b)  Lessee shall pay full Base Rent and Lessee's Share of Common Area
          Operating Expenses and Real Property Taxes for the entirety of the
          Premises at the earlier of (i) one hundred twenty (120) days
          following the Commencement Date, or (ii) at such time as Suites A,
          B and C are tendered to Lessee with the Tenant Improvements
          substantially complete and a certificate of occupancy (or
          comparable "right to occupy") has been issued by the City of San
          Diego for Suites A, B, and C. Landlord shall give notice to Tenant
          of the date from which Lessee is to pay full Base Rent and Lessee's
          Share of Common Area Operating Expenses and Real Property Taxes.

51.  TENANT IMPROVEMENTS AND TENANT IMPROVEMENT ALLOWANCE.

     Lessor shall construct tenant improvements ("Tenant Improvements", and
     sometimes "Alterations" as defined in Paragraph 7.3 of the Lease) in
     Suites A, B and C and D of the Premises pursuant to a mutually-approved
     space plan at a cost to Lessor not to exceed $50.00 per square foot of
     rentable area ($50.00 x 10,612 SF = $530,600) ("Tenant Improvement
     Allowance"). The costs of Tenant Improvements payable from the Tenant
     Improvement Allowance shall include all costs expended by Lessor
     relative to the construction of the Tenant Improvements, including but
     not limited to costs of equipment, material and labor; contractor's
     field overhead and fees; cost of preparation of preliminary space plans
     and specifications and working drawings; governmental agency fees
     relating to the construction; costs of any requirements regarding
     construction which are imposed by any federal, state or local governmental
     entity or agency which are not reflected in the approved plans and
     specifications; sales and use taxes (but not real property taxes); permits;
     plan check fees; bonds; demolition; water and sewer connection charges, if
     any; and other costs directly related to the construction of the Tenant
     Improvements. Lessee shall pay all costs related to or in connection
     with the Tenant Improvements in excess of the Tenant Improvement Allowance
     as they are incurred. Lessee shall not be entitled to receive any payment
     or credit, or any off-set or deduction against any monetary obligation of
     Lessee under the Lease, for any portion of the Tenant Improvement Allowance
     which is not expended by Lessor.

                                                     Initials: GT
                                                               --
                                                               NC
                                                               --

                                        1
<PAGE>

52.      BASE RENT INCREASE.

Notwithstanding anything to the contrary set forth in Paragraph 4 of the Lease,
on August 1, 2001 and on the first (1st) day of each August thereafter during
the term, the Base Rent then in effect shall be increased by three percent (3%)
per annum.

53.      SECURITY DEPOSIT.

         (a)      The Security Deposit may consist of cash or an irrevocable
                  stand-by letter of credit ("Letter of Credit"). Lessee shall
                  be responsible for any expenses in obtaining and maintaining
                  any Letter of Credit. The Letter of Credit, and any
                  replacement Letter of Credit, shall be issued by a bank or
                  other financial institution reasonably acceptable to Lessor
                  with an office in San Diego, California. Should the
                  institution be placed in conservatorship or receivership by
                  the Federal Deposit Insurance Corporation or any other state
                  or federal regulatory agency, Lessee shall, within thirty (30)
                  days after written request by Lessor, provide a replacement
                  Letter of Credit from a financial institution reasonably
                  acceptable to Lessor, and in the event Lessee fails to do so,
                  Lessor may draw on the Letter of Credit and use the proceeds
                  thereof as a cash security deposit in accordance with the
                  provisions of Paragraph 5 of the Lease.

         (b)      The Letter of Credit shall provide (i) that the issuer of the
                  Letter of Credit shall pay to Lessor the amount in default
                  immediately upon presentation of a sight draft by Lessor
                  accompanied by a certified statement signed by the general
                  partner of Lessor (or, if any successor Lessor is a
                  corporation or a limited liability company, by any officer of
                  the corporation or manager of the limited liability company,
                  as the case may be) stating that a default has occurred under
                  the Lease as a result of which Lessor is entitled to collect
                  the amount specified in the site draft in order to cure the
                  default, and (ii) that the issuer shall have no obligation to
                  confirm that a default has occurred, or the amount which
                  Lessor is entitled to draw, or that notice of the default has
                  been given to Lessee.

         (c)      The initial Letter of Credit shall be for a period of not less
                  than one (1) year, and any replacement Letter of Credit shall
                  be for a period of not less than one (1) year. The initial
                  Letter of Credit (or any later replacement Letter of Credit)
                  shall be replaced by Lessee by delivering to Lessor a
                  replacement Letter of Credit at least thirty (30) days prior
                  to the expiration of the then current Letter of Credit. If
                  Lessee fails to deliver a replacement Letter of Credit at
                  least thirty (30) days prior to the expiration of the then
                  current Letter of Credit, Lessor shall have the right, upon
                  two (2) business days notice to Lessee, to draw the total
                  amount of the then current Letter of Credit and hold the
                  proceeds thereof as a cash security deposit pursuant to the
                  provisions of Paragraph 5 of the Lease. The Letter of Credit
                  shall be successively renewed or replaced until that date
                  which is thirty (30) days after the expiration of the initial
                  or any extended term of the Lease.

         (d)      In the event of a partial draw on the Letter of Credit to cure
                  a Lessee default, Lessee shall, pursuant to Paragraph 5 of the
                  Lease, within ten (10) days after written request therefor
                  deposit cash with Lessor sufficient to restore the Security
                  Deposit to the full amount required by the Lease, or
                  substitute a new Letter of Credit to the full amount required
                  by the Lease.

         (e)      Any cash deposit or Letter of Credit shall be transferable by
                  Lessor to a successor Lessor or mortgagee or beneficiary of a
                  deed of trust encumbering the Premises, or, in the case of a
                  Letter of Credit, a substitute Letter of Credit shall be
                  issued to any such entity at the request of Lessor; provided,
                  however, that Lessor shall pay any expenses incurred by Lessee
                  on account of any such transfer or issuance.

         (f)      In the event of bankruptcy or other debtor/creditor
                  proceedings against Lessee, the Security Deposit shall be
                  deemed to be applied first to the payment of rent and other
                  charges due Landlord for all periods prior to the filing of
                  such proceedings.

                                                     Initials: GT
                                                               --
                                                               NC
                                                               --

                                       2
<PAGE>

         (g)      Lessor shall deliver the Security Deposit to any purchaser of
                  Lessor's interest in the Premises, and thereupon Lessor shall
                  be discharged from any further liability with respect thereto
                  provided that such purchaser has agreed to assume in writing
                  the obligations of Lessor under the Lease.

54.      DAMAGE AND DESTRUCTION.

Notwithstanding anything to the contrary set forth in Paragraph 9 of the Lease,
Lessee hereby waives the provisions of California Civil Code Sections 1932 and
1933, and any successor sections and any other statutes which are inconsistent
with the provisions of the Lease and which relate to the termination of leases
when leased property is destroyed, and agree that such event shall be governed
by the terms of the Lease.

55.      COMMON AREA OPERATING EXPENSES.

         Notwithstanding anything to the contrary set forth in the Lease, Common
         Area Operating Expenses shall include, in addition to those items
         listed in Paragraph 4.2 of the Lease, all expenses incurred by Lessor
         in operating, maintaining and repairing the Building and the Industrial
         Center, as determined by standard accounting practices, including, but
         not limited to: water and sewer charges (if not separately metered to
         Lessee); the cost of utilities, janitorial services, security and labor
         (if not separately metered to Lessee); paring charges, surcharges or
         any other costs levied, assessed or imposed by, or at the direction of,
         or resulting from statutes or regulations promulgated by any federal,
         state or local governmental authority in connection with the use of
         occupancy of the Building or the Industrial Center; the cost (amortized
         over the reasonably anticipated useful life of the asset, together with
         interest at the maximum rate allowable by law of the unamortized
         balance) of (i) any capital improvements made to the Building or the
         Industrial Center by Lessor to the extent such capital improvements
         reduce Common Area Operating Expenses or which are made to the Building
         or the Industrial Center by Lessor after the commencement date of the
         Term as required pursuant to any law or regulation that was not
         applicable at the time they were constructed, or (ii) replacement of
         any equipment needed to operate the Building or the Industrial Center
         at a consistent level or quality, but only in the event that such
         equipment (A) is malfunctioning or non-functioning and the repair of
         such equipment would not be economically feasible when compared to the
         cost of replacement, or (B) is otherwise due for replacement in the
         ordinary course of its reasonably anticipating useful life; costs
         incurred in the management of the Building or the Industrial Center, if
         any, including an industry standard management fee, supplies, wages and
         salaries of employees used in the management, operation and maintenance
         of the Building and the Industrial Center, and payroll taxes and
         similar governmental charges with respect thereto, and the Building or
         the Industrial Center management office rental (but only to the extent
         such management office is used for the management of the Building or
         the Industrial Center); the cost of air-conditioning, waste disposal,
         heating and ventilation (if not separately metered to Lessee);
         maintenance, supplies, materials, equipment and tools; the costs of
         repair and maintenance of the Building and the Industrial Center,
         including payroll expenses and rental of personal property used in
         connection therewith; costs of gardening and landscaping; costs of
         maintaining signs; personal property taxes levied on or attributable to
         personal property used in connection with the operation, maintenance
         and repair of the Building or the Industrial Center; reasonable audit
         or verification fees; and the costs of resurfacing, painting, lighting,
         cleaning, refuse removal and similar items, including appropriate
         reserves, for the Building and the Industrial Center. Common Area
         Operating Expenses shall not include depreciation on the Building of
         the Industrial Center or any equipment therein, Lessor's executives'
         salaries or real estate brokers' commissions.

56.      LESSEE'S INSURANCE.

         Lessee's insurance, as set forth in Article 8 of the Lease, shall
         include coverage for damage resulting from a flood at the subject
         property. In addition, all such insurance required to be maintained by
         Lessee shall name Lessor, the management company of the Industrial
         Center, and any mortgagees of Lessor, as additional insureds.

                                                     Initials: GT
                                                               --
                                                               NC
                                                               --

                                       3
<PAGE>

57.    ASSIGNMENT AND SUBLETTING.

       (a)    In connection with any proposed assignment of the Lease or
              sublease of all or any portion of the Premises, Lessee shall
              deliver to Lessor, for Lessor's review and written approval,
              all such information concerning the proposed assignee or
              sublessee as Lessor may reasonably require or request,
              including, but not limited to, any financial statements or
              other financial information and all terms of the proposed
              assignment or sublease.

       (b)    Notwithstanding anything to the contrary set forth in
              Paragraph 12.4 of the Lease, Lessee hereby assigns and
              transfers to Lessor one hundred percent (100%) of all of
              Lessee's interest in and to all rent and other consideration
              arising from any assignment or sublease of the Premises
              hereafter made by Lessee, and Lessor may collect such rent and
              other consideration and apply same toward Lessee's obligations
              under the Lease; provided, however, that until a default shall
              occur in the performance of Lessee's obligations under the
              Lease, Lessee may receive and collect such rent and other
              consideration accruing under any assignment or sublease. Lessee
              hereby irrevocably authorizes and directs any assignee or
              sublessee, upon receipt of written notice from Lessor stating
              that a default exists in the performance of Lessee's obligations
              under the Lease, to pay to Lessor one hundred percent (100%) of
              the rent due and to become due under the assignment or sublease.
              Leassee agrees that any assignee or sublessee shall have the
              right to rely upon any such written notice from Lessor, and that
              such assignee or sublessee shall pay such rent to Lessor without
              any obligation or right to inquire as to whether a default
              exists, and notwithstanding any notice from or claim from Lessee
              to the contrary, Lessee shall have no right or claim against
              such assignee or sublessee or Lessor for any rent and other
              consideration so paid by such assignee or sublessee to Lessor.

       (c)    Lessor shall have the right to terminate this Lease as to that
              portion of the Premises covered by a proposed assignment of the
              Lease or Sublease. Lessor may exercise such right to terminate
              by giving notice to Lessee at any time within thirty (30) days
              after the date on which Lessee has furnished to Lessor all of
              the items required under Sections 12 and 57. If Lessor exercises
              such right to terminate, Lessor shall be entitled to recover
              possession of, and Lessee shall surrender such portion of, the
              Premises (with appropriate demising partitions erected at the
              expense of Lessee) on the later of (i) the effective date of the
              proposed assignment or sublease, or (ii) sixty (60) days after
              the date of Lessor's notice of termination. In the event Lessor
              exercises such right to terminate, Lessor shall have the right
              to enter into a lease with the proposed assignee or sublessee
              without incurring any liability to Lessee on account thereof.

58.    BROKERS.

       Lessee warrants and represents that Lessee has not dealt with any real
       estate broker or agent in connection with the Lease or its
       negotiation, except for the broker identified in paragraph 1.10(a) of
       the Lease. Lessee shall indemnify and hold Lessor and the Premises
       harmless from and against any and all costs, expenses and liability
       (including actual attorney's fees and court costs) for any
       compensation, commission or fees claimed by any other real estate
       broker or agent in connection with the Lease or its negotiation based
       upon any act of Lessee. Lessor warrants and represents to Lessee that
       Lessor has not dealt with any real estate broker or agent in connection
       with the Lease or its negotiations, except for the broker identified in
       Paragraph 1.10(a) of the Lease. Lessor shall indemnify and hold Lessee
       harmless from and against any and all costs, expenses and liability
       (including actual attorneys' fees and court costs) for any
       compensation, commission or fees claimed by any other real estate
       broker or agent in connection with the lease or its negotiation based
       upon any act of Lessor.

59.    HAZARDOUS MATERIAL.

       Upon the expiration or earlier termination of the Lease, Lessee shall
       at its own expense cause a Phase I Environmental Site Assessment of
       the Premises to be conducted, and a Phase II

                                                     Initials:   GT
                                                               -------
                                                                 NC
                                                               -------
                                       4
<PAGE>

        Environmental Site Assessment if recommended by the Phase I report,
        and a report thereof delivered to Lessor, such report to be as
        complete and broad in scope as is necessary to identify any impact on
        the Premises Lessee's operations might have had (hereinafter referred
        to as the "Exit Report"). Lessee shall correct any deficiencies
        identified in the Exit Report in accordance with its obligations under
        Article 6 and other applicable provisions of the Lease prior to the
        expiration or earlier termination of this Lease.

60.     LIMITATION ON LIABILITY.

        Notwithstanding anything to the contrary set forth in the Lease, the
        obligations of Lessor, and Lessor's partners (either general or
        limited), directors, officers and shareholders, under the Lease do
        not constitute personal obligations. Lessee, and Lessee's successors
        and assigns, hereby agree not to seek recourse against the personal
        assets of Lessor, or Lessor's partners (either general or limited),
        directors, officers and shareholders, for satisfaction of any actual
        or alleged liability of lessor to Lessee under the Lease, but Lessee
        shall look only to Lessor's interest in the Building for the
        satisfaction of any liability of Lessor to Lessee hereunder.

61.     NOTICES.

        Copies of all notices or any other documents required to be delivered
        to either Lessor or Lessee, or both, pursuant to the terms of the
        Lease (including any changes to the address of either Lessor or
        Lessee), shall be delivered to the parties, in accordance with
        Paragraph 23 of the Lease, at the following addresses:

              If to Lessee:            ELITRA PHARMACEUTICALS, INC.
                                       3510 Dunhill St
                                       ----------------------------
                                       San Diego, CA 32121
                                       ----------------------------

                                       ----------------------------
                                       Attn: Greg Tibbitts
                                            -----------------------

              If to Lessor:            SORRENTO WEST PARTNERS, L.P.
                                       YALE PROPERTIES USA, INC.
                                       6256 Greenwich Drive
                                       Office of the Building
                                       San Diego, CA 92122
                                       Attn: Mr. Jeffrey Burges

              With copy to:            SORRENTO WEST PARTNERS, L.P.
                                       C/O BARROW STREET CAPITAL
                                       31 W. 52nd Street, 16th Floor
                                       New York, NY 10019

62.    HOLDING OVER.

       If Lessee fails to surrender the Premises upon the expiration or
       earlier termination of the Term without the express written consent of
       Lessor, Lessee shall become a tenant-at-sufferance at the rental rate
       equal to two hundred percent (200%) of the monthly rent payable by
       Lessee for the month immediately preceding such expiration or earlier
       termination, and Lessee shall remain responsible for the payment of all
       other monetary obligations due and payable by Lessee under the Lease.
       Acceptance by Lessor of rent after such expiration or earlier
       termination of the Term shall not result in any renewal of the term.
       The foregoing provisions are in addition to and do not affect Lessor's
       right of re-entry or any other rights or remedies of Lessor hereunder
       or as otherwise provided at law or in equity, or both. If Lessee fails
       to surrender the Premises upon the expiration or earlier termination of
       the term despite Lessor's demand to do so, Lessee shall indemnify and
       hold Lessor harmless from and against any and all losses, costs,
       damages and liability (including actual attorneys' fees and costs, and
       court costs), direct or indirect, which Lessor may suffer as a result
       of Lessee's failure to surrender the Premises.

                                                           Initials:   GT
                                                                    -------
                                                                       NC
                                                                    -------
                                       5
<PAGE>

63.    SIGNAGE.

       Lessee may install signage on the Premises at its expense to the
       extent permitted by, and in conformity with, applicable provisions of
       the City of San Diego Sign Ordinance and the Sign Criteria attached to
       the Lease as Exhibit "B". The Sign Criteria may be revised from time
       to time in Lessor's reasonable discretion.

64.    PARKING.

       Notwithstanding anything to the contrary set forth in Paragraph 2.6 of
       the Lease, Lessee may be entitled to use, during the Term, the parking
       areas associated with the Premises for parking by Lessee, and Lessee's
       employees, visitors and customers, subject to any rules and
       regulations promulgated by or parking fees charged by Lessor, as the
       same may be established from time to time. All responsibility for
       damage and theft to vehicles is assumed by Lessee and Lessee's
       employees, visitors and customers. Lessee shall repair or cause to be
       repaired, at Lessee's sole cost and expense, any and all damage to the
       Building and the Industrial Center caused by Lessee's, or Lessee's
       employees', visitors' or customers' use of such parking areas therein.

65.    WAIVER OF JURY TRIAL.

       Lessor and Lessee hereby waive their respective right to trial by jury
       of any cause of action, claim, counterclaim, or cross-complaint in any
       action, proceeding and/or hearing brought by either Lessor against
       Lessee or Lessee against Lessor on any matter whatsoever arising out
       of, or in any way connected with, this lease, the relationship of
       Lessor and Lessee, Lessee's use and occupancy of the Premises, the
       Building and/or the Industrial Center, or any claim of injury or
       damage, or the enforcement of any remedy under any law, statute, or
       regulation, emergency or otherwise, now or hereinafter in effect.

67.    INSTALLATION OF LABORATORY BENCHES. Prior to the time the Premises are
       surrendered to Lessor, Lessee shall, at its sole cost and expense,
       install a two-sided bench with shelving in Suites C and D, of the same
       size, type and standard as the benches installed in Suites A and B as
       part of the Tenant Improvements, which benches shall be surrendered
       with the Premises and become the property of Lessor at the expiration
       or earlier termination of the term.

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /

/ / / /
                                                           Initials:   GT
                                                                    -------
                                                                       NC
                                                                    -------
                                       6

<PAGE>

     IN WITNESS WHEREOF, LESSOR AND LESSEE HAVE EXECUTED THIS ADDENDUM
CONCURRENTLY WITH THE LEASE OF EVEN DATE HEREWITH.

LESSEE:

ELITRA PHARMACEUTICALS, INC.
a Delaware corporation

By:     /s/  Harry Hixson
      ----------------------------
Name:        Harry Hixson
      ----------------------------

Title:       CEO
      ----------------------------

By:     /s/  Greg Tibbitts
      ----------------------------

Name:        Greg Tibbitts
      ----------------------------

Title:       Director of Finance
      ----------------------------

LESSOR:

SORRENTO WEST PARTNERS, L.P.,
a California limited partnership

By:   Barrow Street Gliders, LLC,
      a Delaware limited liability company
      Its General Partner

      By:   Barrow Street Real Estate Fund L.P.,
            a Delaware limited partnership
            Its Sole Member

            By:   Barrow Street Capital LLC,
                  a Delaware limited liability company
                  Its General Partner

                  By:   Barrow Street Partners, LLC,
                        a Delaware limited liability company
                        Its Managing Member

                        By:     /s/ Nicholas Chermayoff
                              --------------------------------------
                        Name:       Nicholas Chermayoff
                              --------------------------------------
                        Title:  Member

                                       7
<PAGE>

                                  EXHIBIT A-1

                                   SITE PLAN

                          SORRENTO WEST INDUSTRIAL PARK
                              San Diego, California

                Address: 11055 Flintkote Avenue, Suite A, B, C, & D

                           Totaling 162,727 Square Feet

This plan is intended only to show the general layout of the property or a
part thereof. Lessor reserves the right to alter, vary, add to or omit, in
whole or in part, any structures, and/or improvements, and/or common areas,
and/or land areas shown on this plan. All measurements and distances are
approximate. This plan is not to be scaled.

                                INDUSTRIAL CENTER
                         Approximately 162,727 Square Feet

                                      [MAP]

                           APPROXIMATE DEMISED PREMISES

                                      [MAP]

                                                           Initials:   GT
                                                                    -------
                                                                       NC
                                                                    -------
<PAGE>

                                   EXHIBIT B

                                 SIGN CRITERIA

Sign Criteria establishes the uniform policies for all lessee sign
identification. This criteria has been established for the purpose of
maintaining the overall appearance of the project. Conformance will be strictly
enforced. Any sign installed that does not conform to the sign criteria will be
brought into conformity at the expense of the Lessee.

A.   GENERAL REQUIREMENTS

     1.   A drawing of all proposed Lessee's signs indicating copy, sizes,
          color, and locations shall be submitted to the Morlin Management
          Corporation, prior to fabrication of any sign.

     2.   Morlin Management Corporation shall approve all copy and/or logo
          design and color prior to the fabrication of the sign, which approval
          shall occur in a timely manner and shall not be unreasonably withheld.

     3.   Morlin Management Corporation shall direct the placement of all
          Lessee's signs and the method of attachment to the building.

     4.   Lessee shall be responsible for the fulfillment of requirements for
          this criteria.

     5.   Sign fabrication and installation shall be paid for by the Lessee.

B.   GENERAL SPECIFICATIONS

     1.   Lessee shall be allowed one (1) corporate name and logo sign per
          building regardless of size of occupancy.

     2.   Lessee shall be allowed to install one (1) additional sign as a
          monument sign. The face of the sign shall not exceed a width of four
          feet (4') and a height of two feet (2'). The top of the sign shall not
          exceed four feet (4') in height above ground level.

     3.   Lessee shall be allowed to install signs identifying non-reserved
          parking, shipping, receiving, and other areas of the Premises which
          require proper identification for third parties conducting business
          with Lessee, as well as other signs that are required pursuant to
          Federal, State or Local Municipal Laws and Regulations.

     4.   All signs to be of individual letters and logos consistent with the
          style, color and size of all others in the Industrial Park. No cans,
          frames or panels are permitted.

     5.   No electrical or audible signs will be allowed.

     6.   Upon the removal of any sign, any damage to the building will be
          prepared by the Lessee, except for any damage resulting from negligent
          or otherwise improper removal of a sign by a party acting under the
          direction of Lessor.

     7.   Except as provided herein, no advertising placards, banners, pennants,
          names, insignia, trademarks, or other descriptive material shall be
          affixed or maintained upon any external automated machine, glass panes
          of the building, landscaped areas, streets or parking areas, except
          for signs indicating the Premises are protected by security services.
          Lessee when the premises are vacated at the end of the Lease term.
          Except as provided herein, no advertising placards, banners, pennants,
          names, insignia, trademarks, or other descriptive material shall be
          affixed or maintained upon the glass panes of the exterior walls of
          the building, landscaped areas, streets, or parking areas.

     8.   Lessee has permission to have an eighty-eight (88) inch wide window
          sign which is equivalent to two normal size (forty-four inch) window
          signs. Lessee is authorized to have a lawn sign at the time that
          Lessee expands to occupy the entire Building #3.

                                                           Initials:   GT
                                                                    -------
                                                                       NC
                                                                    -------
<PAGE>

                                   EXHIBIT C

                              RULES & REGULATIONS

Lessee hereby agrees to the following:

     a.   REFUSE - All garbage and refuse shall be kept in the container
          supplied by Lessor and placed at the location prepared for refuse
          collection, in the manner at the times and places specified by
          Lessor.

     b.   PARKING - Lessee shall be entitled to park in common with other
          tenants of Lessor. Lessee agrees not to overburden the parking
          facilities and agrees to cooperate with Lessor and other tenants in
          the use of the parking facilities. Lessor reserves the right in its
          absolute discretion to determine whether parking facilities are
          becoming crowded and, in such event, to allocate parking spaces among
          Lessees or to designate specific areas within which Lessee must park.

     c.   No equipment shall be erected on the roof or exterior walls of the
          Leased Premises, or on the grounds, without in each instance, the
          written consent of the Lessor. Any equipment so installed without such
          written consent shall be subject to removal without notice at any
          time.

     d.   No loud speakers, televisions, phonographs, radios or other devices
          shall be used in a manner so as to be heard or seen outside of the
          premises without the prior written consent of the Lessor.

     e.   The outside areas immediately adjoining the Leased Premises shall be
          kept clean and free from dirt and rubbish by the Lessee to the
          satisfaction of the Lessor, and Lessee shall not place or permit any
          obstruction or materials in such areas. No exterior storage shall be
          allowed without permission in writing from Lessor.

     f.   The plumbing facilities shall not be used for any other purpose than
          that for which they are constructed, and no foreign substance of any
          kind shall be thrown therein, and the expense of any breakage,
          stoppage, or damage resulting from a violation of this provision shall
          be borne by Lessee, who shall, or whose employees, agents or invitees
          shall have caused it.

     g.   Lessee shall use at Lessee's cost such pest extermination contractor
          as Lessor may direct and at such intervals as Lessor may require in
          the event that the service needed is due to the Lessee's activities.

     h.   Lessee shall not burn any trash or garbage of any kind in or about the
          Leased premises, or the industrial center.

     i.   If the premises are air conditioned, Lessee shall provide to Lessor,
          within thirty (30) days after occupancy, an air conditioning
          maintenance contract. Lessee hereby authorizes Lessor to obtain a
          maintenance contract, to be paid for by Lessee, in the event that
          Lessor request in writing an air conditioning service contract and
          such contract satisfactory to Lessor is not received in Lessor's
          office within ten (10) days of the written request. If Lessee refuses
          or neglects to repair properly as required hereunder and to the
          reasonable satisfaction of Lessor as soon as reasonably possible after
          written demand, Lessor may make such repairs without liability to
          Lessee for any loss or damage that may accrue to Lessee's merchandise,
          fixtures, or other property or the Lessee's business by reason
          thereof, and upon completion thereof, Lessee shall pay Lessor's costs
          for making such repairs plus twenty (20%) percent for overhead, upon
          presentation of bill therefore, as additional rent. Said bill shall be
          payable Net 30, with interest at ten (10%) percent accruing on said
          cost beginning thirty (30) days after the date of invoicing of repairs
          by Lessor.

     j.   Lessor reserves the right from time to time to amend or supplement the
          foregoing rules and regulations, and to adopt and promulgate
          additional reasonable rules and regulations applicable to the Leased
          Premises. Notice of such rules and regulations and amendments and
          supplements thereto, if any, shall be given to the Lessee.

                                                           Initials:   GT
                                                                    -------
                                                                       NC
                                                                    -------
<PAGE>

                                  EXHIBIT D

                               LEGAL DESCRIPTION

                          SORRENTO WEST INDUSTRIAL PARK
                             SAN DIEGO, CALIFORNIA

LOTS 1 THROUGH 9 OF PACIFIC SORRENTO INDUSTRIAL PARK, IN THE CITY OF SAN
DIEGO, COUNTY OF SAN DIEGO, STATE OF CALIFORNIA, ACCORDING TO MAP THEREOF
NO. 7748, FILED IN THE OFFICE OF THE COUNTY RECORDER OF SAN DIEGO COUNTY,
SEPTEMBER 25, 1973.

<PAGE>

                                  EXHIBIT "F"

                          TENANT ESTOPPEL CERTIFICATE

      RE:  LEASE DATED: 4/21/00
           BETWEEN: SORRENTO WEST PARTNERS, LP
           AS SUCCESSOR LANDLORD,
           AND ELITRA PHARMACEUTICALS, INC., TENANT
           FOR PREMISES LOCATED AND ADDRESSED AS: 11055 FLINTKOTE AVENUE
           SUITES A,B,C, & D

Ladies and Gentlemen:

           We understand that JBC SORRENTO WEST, LLC, CALIFORNIA LIMITED
LIABILITY COMPANY ("Landlord") has acquired or will be acquiring the real
property of which our premises are a part.  The undersigned, as tenant
("Tenant"), has been advised that the above described lease (the "Lease")
has been or will be assigned to you as security for a loan to Landlord, and
as an inducement therefor and for Landlord to acquire the real property,
hereby confirms the following:

           1.  The Lease is a valid and binding agreement enforceable against
               Tenant in accordance with its terms, and is in full force and
               effect and has not been modified or amended by Landlord (or its
               predecessor-in-interest) and/or Tenant, except as follows:
               NONE (the term "Lease" as used hereinafter shall be deemed to
               include the foregoing modifications and amendments).      .

           2.  Except as described in paragraph 1 above, there are no
               agreements, oral or written, between Landlord (or its
               predecessor-in-interest) and Tenant relating to Tenant's
               occupancy of the premises other than the Lease.

           3.  Tenant is paying the full rent stipulated under the Lease,
               without offset, defense or claim of any kind; all rents and
               other charges due from Tenant under the Lease have been paid,
               but not more than one month in advance of their respective due
               dates; Tenant began paying rent on 5/2/00 FOR SUITE D & 8/29/00
               FOR SUITES A - C; the current monthly rent under the Lease is
               $5,386.50.  The Lease also provides for additional rent as
               follows: $575.29 (COMMON AREA EXPENSES), NONE (UTILITY
               REIMBURSEMENT).  Tenant prepaid rent in the amount of NONE.

<PAGE>

           4.  Neither Landlord (or its predecessor-in-interest) nor Tenant
               is in breach of any of the terms of the Lease, and neither
               Landlord nor Tenant has committed any act that will notice or
               the passage of time or both could give rise to any breach
               under the Lease, and there are no actions, voluntary or
               otherwise, pending or threatened against Tenant under any
               federal or state bankruptcy laws.

           5.  Landlord and Tenant have not agreed to any material concessions
               or inducements to Tenant with respect to the Lease (e.g. as to
               rent abatement or additional funds for tenant improvements)
               not otherwise identified in this certificate, except as
               follows: TENANT HAS A TENANT IMPROVEMENT ALLOWANCE OF
               $50.00/S.F..

               Tenant has not assigned, transferred, sublet, hypothecated,
               pledged, mortgaged or otherwise alienated any of its interest
               under the Lease, except as follows: NONE.

               The premises consist of approximately 10,612 square feet of space
               and Tenant has no right or option to lease any additional space
               in the property, except as follows: NONE.

           6.  Landlord is holding a security deposit from Tenant in the
               amount of $133,711.00.

           7.  Tenant has no option or right of first refusal to purchase the
               property.

           8.  The Lease expires on 9/30/03 and Tenant has only the following
               options to extend or renew the Lease: NONE.

           9.  Any tenant improvements to be made by Landlord (or its
               predecessor-in-interest) have been completed in a manner
               satisfactory to Tenant, and Tenant has accepted, is conducting
               business in, and is in full possession of, the premises.

           10. Notwithstanding the above-referenced assignment of the Lease
               to you, Tenant understands and acknowledges that: (i) all
               rentals and other payments due under the terms of the Lease
               shall continue to be paid in accordance with the terms of the
               Lease until and unless Tenant is notified to the contrary in
               writing by you, in which event Tenant shall pay the same
               directly to you; and (ii) you assume no duty, liability or
               obligation under the Lease, either by virtue of said
               assignment, the exercise of remedies thereunder, or any
               subsequent

                                       2
<PAGE>

               receipt or collection of rentals or any other sums due under
               the terms of the Lease until such time, if any, as you become
               the owner of the premises by foreclosure or otherwise.

           11. You shall not be:

                 (a)  liable for any act or omission of any person or party
                      who may be a landlord under the Lease prior to your
                      acquisition of title to said premises ("Prior
                      Landlord");

                 (b)  liable for the return of any security or cleaning
                      deposits paid to any Prior Landlord and not actually
                      delivered or paid over to you; or

                 (c)  subject to any off-sets or defenses which Tenant may
                      have against any Prior Landlord.

           12. The terms "Landlord" and "Tenant," as used herein, shall be
               deemed to mean "Lessor" or "Owner" and "Lessee," respectively,
               if the parties are so called in the Lease.

           The above statements are made with the understanding that you will
rely on them in connection with the above-mentioned loan.

                                       Very truly yours,

                                       TENANT:

                                       By:     /s/ Greg Tibbitts
                                           --------------------------------

                                       Name:       Greg Tibbitts
                                             ------------------------------

                                       Title:      Director of Finance
                                              -----------------------------

                                      -3-
<PAGE>

                        SORRENTO WEST INDUSTRIAL COMPLEX
                         ESTIMATED OPERATING EXPENSES
                        May 2, 2000 - December 31, 2000
                              Number of Months: 7

ELITRA
11055 Flintkote Ave.       Suite:     9D

<TABLE>
<CAPTION>

Project Square Footage:                 162,727                 Tenant Square Footage:                 2,640
Expenses Excluded:
Lease Commencement:                      5/2/00                 Base Year:                     NNN
-------------------------------------------------------------------------------------------------------------
OPERATING RESULTS:
-------------------------------------------------------------------------------------------------------------
<S><C>
CAM:                   2000     Total CAM Costs                                                $  239,607.26

                                Tenant's Prorata Share (per Lease)     1.62%                   $    3,887.27
                                                                                               ==============

INSURANCE:             2000     Total Insurance Costs                                          $   45,089.00

                                Tenant's Prorata Share (per Lease)     1.62%                   $      731.50
                                                                                               ==============

TAXES:                 2000     Total Tax Cost                                                 $  140,828.00

                                Tenant's Prorata Share (per Lease)     1.62%                   $    2,284.72
                                                                                               ==============

                                Total Billable Expenses for Year                               $    6,903.49
                                Less Base Year CAP                                             $         -
                                                                                               --------------
                                Net Billable Expenses for Year                                 $    6,903.49

                                Total Billable Expenses for Period (1/00 - 5/00)        41.67% $    2,876.45
                                Less Expenses Paid for Period (1/00 - 5/00)                    $         -
-------------------------------------------------------------------------------------------------------------
AMOUNT DUE OR (CREDIT) FOR PERIOD (1/00 - 5/00)                                                $         -
-------------------------------------------------------------------------------------------------------------

                                Remaining Expenses Due or (Credit) for Year                    $    4,027.04
-------------------------------------------------------------------------------------------------------------
REMAINING EXPENSES DUE OR (CREDIT) PER MONTH                                                   $      575.29
-------------------------------------------------------------------------------------------------------------
</TABLE><PAGE>

                                                                  EXHIBIT 10.21

                                          *** TEXT OMITTED AND FILED SEPARATELY
                                               CONFIDENTIAL TREATMENT REQUESTED
                                          UNDER 17 C.F.R. SECTIONS 200.80(b)(4)
                                                            200.83 AND 230.406.

                                LICENSE AGREEMENT

         THIS LICENSE AGREEMENT, dated as of April 30, 1998 (the "Effective
Date") is made by and between RAJYABIOTICS, a corporation organized under the
laws of the State of California (the "Company"), and SAN DIEGO STATE UNIVERSITY
FOUNDATION, a not-for-profit research institution organized under the laws of
the State of California (the "Foundation").

         WHEREAS, the Foundation possesses proprietary methods of identifying
genes and protein products and possesses proprietary genes and protein products
covered by certain patent rights;

         WHEREAS, the Company is engaged in the discovery, development and
commercialization of chemical compounds for therapeutic applications; and

         WHEREAS, the Foundation wishes to grant to the Company, and the Company
wishes to obtain from the Foundation, an exclusive license under certain patent
rights held by the Foundation on the terms and subject to the conditions set
forth herein.

         NOW, THEREFORE, in consideration of the mutual covenants and promises
hereinafter set forth, the parties hereto hereby agree as follows:

                                    ARTICLE 1
                                   DEFINITIONS

         1.1  "AFFILIATE" means any corporation or other entity which
controls, is controlled by, or is under common control with, a party to this
Agreement. A corporation or other entity shall be regarded as in control of
another corporation or entity if it owns or directly or indirectly controls
more than 50% of the voting stock or other ownership interest of the other
corporation or entity, or if it possesses, directly or indirectly, the power
to direct or cause the direction of the management and policies of the
corporation or other entity.

         1.2  "CONFIDENTIAL INFORMATION" means any confidential information,
including information related to the Licensed Technology, and any other
information relating to any compound, research project, work in process,
future development, scientific, engineering, manufacturing, marketing,
business plan, financial or personnel matter relating to either party, its
present or future products, sales, suppliers, customers, employees, investors
or business, whether in oral, written, graphic or electronic form.

         1.3  "CONTROL" means possession of the ability to grant a license or
sublicense as provided for herein without violating the terms of any
agreement or other arrangement with any Third Party.

         1.4  "DRUG TARGET" means a defined physical chemical entity that is
a gene or protein that can be inhibited by a therapeutic agent, which is
discovered or developed by the Company through the use of any invention
within the scope of any Valid Claim.

                                      1.

<PAGE>

         1.5  "FDA" means the United States Food and Drug Administration.

         1.6  "FUTURE INVENTIONS" means all inventions related to the
identification of gene or protein products, or to the use of gene or protein
targets, in the discovery of new pharmaceuticals or diagnostics, which are
conceived of or reduced to practice in Dr. Judith Zyskind's laboratory at the
University after the Effective Date, and which the Company believes are
relevant to its commercial interests, and until (a) the effective date of
[... *** ...], or (b) the [... *** ...] of the effective date of [... *** ...].

         1.7  "KNOW-HOW" means all know-how, trade secrets, inventions, data,
processes, procedures, devices, methods, formulas, protocols and information,
whether or not patentable, which are not covered by the Patent Rights, but
which are necessary or useful for the commercial exploitation of the Patent
Rights and which are owned by or under the Control of the Foundation as of
the Effective Date.

         1.8  "LEAD COMPOUND" means a potential therapeutic agent discovered
or developed by the Company through the use of any invention within the scope
of any Valid Claim.

         1.9  "LICENSED TECHNOLOGY" means the Patent Rights and the Know-How.

         1.10 "PATENT RIGHTS" means the information, inventions and/or
discoveries covered by the patents applications owned by or under the Control
of the Foundation as of the Effective Date and listed in Exhibit A hereto,
including, without limitation, all substitutions, continuations,
continuations-in-part, divisions, reissues and extensions thereof, together
with any foreign counterparts thereof and any and all patents issuing thereon.

         1.11 "TERM" shall have the meaning set forth in Section 8.1.

         1.12 "THIRD PARTY" means any entity other than the Company or the
Foundation or an Affiliate of the Company or the Foundation.

         1.13 "UNIVERSITY" means San Diego State University.

         1.14 "VALID CLAIM" means a claim of an issued patent covered by the
Patent Rights or any Future Inventions, which claim has not lapsed, been
canceled or become abandoned and has not been declared invalid by an
unreversed and unappealable decision or judgment of a court or other
appropriate body of competent jurisdiction, and which has not been admitted
to be invalid or unenforceable through reissue or disclaimer.

                                             *CONFIDENTIAL TREATMENT REQUESTED
                                      2.

<PAGE>

                                    ARTICLE 2

                                GRANT OF LICENSE

         2.1 LICENSE GRANT. Subject to the terms and conditions of this
Agreement and during the Term, the Foundation hereby grants to the Company an
exclusive, worldwide license, including the right to grant unlimited
sublicenses, to practice the Licensed Technology to develop, make, have made,
use, have used, offer for sale, sell and import products and processes, the
manufacture, use or sale of which is covered by the Patent Rights or which
otherwise uses or incorporates the Know-How.

         2.2 SUBLICENSES. The Company shall have the unlimited right to
sublicense or assign the rights granted to it by the Foundation hereunder.
The Company shall notify any sublicensee hereunder of all rights and
obligations of the Company under this Agreement which are sublicensed to such
sublicensee. The Company shall notify the Foundation of any sublicense to the
Licensed Technology granted hereunder.

         2.3 FUTURE INVENTIONS.

                  (a) The Foundation will promptly notify the Company of any
and all Future Inventions. The Company shall notify the Foundation in writing
of its belief that a Future Invention is relevant to its commercial interests
within [... *** ...] following receipt of written notice of such Future
Invention.

                  (b) The Foundation hereby grants to the Company an
exclusive, worldwide license, including the unlimited right to grant
sublicenses, to use and practice any and all Future Inventions. The
Foundation and the University will take all actions necessary or appropriate
to effect such license. The term of the license for each Future Invention
shall begin on the Effective Date and shall end on the expiration of the last
to expire issued patent for such Future Invention or, if no patent issues
under such Future Invention, 15 years after receipt by the Company of such
Future Invention.

                                    ARTICLE 3
                   LICENSE FEE; ROYALTIES; MILESTONE PAYMENTS

         3.1 LICENSE FEE. Upon the closing of the Company's first preferred
stock financing, the Company agrees to pay the Foundation a one-time,
non-refundable license fee of (a) a number of shares of Common Stock of the
Company equal to [... *** ...] % of the outstanding shares of Common Stock of
the Company immediately prior to the closing of the Company's first preferred
stock financing, and (b) $[... *** ...] in cash.

         3.2 ROYALTIES.

                  (a) The Company will pay the Foundation a royalty equal to
[... *** ...]% of up-front fees, royalties and milestone payments received by
the Company or any of its Affiliates from any Third Party for the license of
any FDA-approved new chemical entity discovered or developed by the Company
through the use of any invention within the scope of any Valid Claim; provided

                                             *CONFIDENTIAL TREATMENT REQUESTED
                                      3.

<PAGE>

that total royalties payable by the Company on royalties received with
respect to such new chemical entity from all parties (including royalties
payable to the Foundation) do not exceed [... *** ...]%. If total royalties
payable by the Company on royalties received with respect to such new
chemical entity from all parties (including royalties payable to the
Foundation) exceed [... *** ...]%, then the royalty payable to the Foundation
under this Section 3.2(a) will be reduced on a pro-rata basis with royalties
owed by the Company to all other parties so that the total royalties payable
by the Company equal [... *** ...]%; PROVIDED, HOWEVER, that in no event will
the royalty payable to the Foundation with respect to such new chemical
entity be reduced to an amount less than [... *** ...]%.

                  (b) The Company will pay the Foundation a royalty equal to
[... *** ...]% of up-front fees, royalties and milestone payments received by
the Company or any of its Affiliates from any Third Party for the sale of a
Lead Compound; provided that the total royalty payable to the Foundation
under this Section 3.2(b) with respect to amounts received for the sale of
all such Lead Compounds will not exceed $[... *** ...].

                  (c) The Company will pay the Foundation a royalty equal to
[... *** ...]% of up-front fees, royalties and milestone payments received by
the Company or any of its Affiliates from any Third Party for the sale of a
Drug Target; provided that the total royalty payable to the Foundation under
this Section 3.2(c) with respect to amounts received for the sale of all such
Drug Targets will not exceed $[... *** ...].

                  (d) The Company will make royalty payments under this
Section 3.2 until expiration of the applicable patent included in the Patent
Rights. Royalties will be payable by the Company under this Section 3.2
regardless of whether the applicable up-front fees, royalties and milestone
payments are received before or after such patent issues. In the event that
no patent included in the Patent Rights issues, no royalties will be payable
by the Company.

                  (e) Notwithstanding the foregoing, no royalties will be
payable to the Foundation on any amounts received by the Company for data,
research and development partnerships, equity investments at fair market
value or pre-commercialization consultation.

         3.3 MILESTONE PAYMENTS. The Company agrees to make a one-time
payment to the Foundation of $[... *** ...] in cash within 10 days following
[... *** ...].

                                    ARTICLE 4
                            PAYMENTS; RECORDS; AUDITS

         4.1 PAYMENT; REPORTS. Royalty payments shall be calculated and
reported for each calendar quarter. All royalty payments due to the
Foundation under this Agreement shall be paid within 60 days of the end of
each calendar quarter, unless otherwise specifically provided herein. Each
payment of royalties shall be accompanied by a report in sufficient detail to
permit confirmation of the accuracy of the royalty payment made, including,
without limitation, the

                                             *CONFIDENTIAL TREATMENT REQUESTED
                                      4.

<PAGE>

royalties payable in U.S. dollars, the method used to calculate the royalty
and the exchange rates used.

         4.2 EXCHANGE RATE; MANNER AND PLACE OF PAYMENT. All payments
hereunder shall be payable in U.S. dollars. With respect to each quarter, for
countries other than the United States, whenever conversion of payments from
any foreign currency shall be required, such conversion shall be made at the
rate of exchange reported in The Wall Street Journal on the last business day
of the applicable reporting period. All payments owed under this Agreement
shall be made by wire transfer, unless otherwise specified by the Foundation.

         4.3 RECORDS AND AUDITS. During the Term and for a period of five
years thereafter, the Company shall keep complete and accurate records in
sufficient detail to permit the Foundation to confirm the accuracy of all
payments due hereunder. The Foundation shall have the right to cause an
independent, certified public accountant reasonably acceptable to the Company
to audit such records to confirm royalty payments for the preceding year.
Such audits may be exercised during normal business hours no more than once
in any 12-month period upon at least 30 working days' prior written notice to
the Company. The Foundation shall bear the full cost of such audit unless
such audit discloses an underpayment by more than 5% of the amount due under
this Agreement. In such case, the Company shall bear the full cost of such
audit.

         4.4 TAXES. All turnover and other taxes levied on account of the
royalties and other payments accruing to the Foundation under this Agreement
shall be paid by the Foundation for its own account, including taxes levied
thereon as income to the Foundation. If provision is made in law or
regulation for withholding, such tax shall be deducted from the royalty or
other payment made by the Company to the proper taxing authority and a
receipt of payment of the tax secured and promptly delivered to the
Foundation. Each party agrees to assist the other party in claiming exemption
from such deductions or withholdings under any double taxation or similar
agreement or treaty from time to time in force.

         4.5 PROHIBITED PAYMENTS. Notwithstanding any other provision of this
Agreement, if the Company is prevented from paying any such royalty by virtue
of the statutes, laws, codes or governmental regulations of the country from
which the payment is to be made, then such royalty may be paid by depositing
funds in the currency in which accrued to the Foundation's account in a bank
acceptable to the Foundation in the country whose currency is involved.

                                    ARTICLE 5
                                 CONFIDENTIALITY

         5.1 CONFIDENTIALITY OBLIGATION. During the Term and for a period of
five years thereafter, each party hereto will maintain in confidence all
Confidential Information disclosed to it by the other party hereto. Neither
party will use, disclose or grant use of such Confidential Information of the
other party, except as expressly authorized by this Agreement. Each party may
disclose to its employees, agents and consultants Confidential Information of
the other party to accomplish the purposes of this Agreement and will obtain
prior agreement from such employees, agents and consultants to whom
disclosure is to be made to hold in confidence and

                                      5.

<PAGE>

not make use of such information for any purposes other than those permitted
by this Agreement. Each party will use at least the same standard of care as
it uses to protect its own trade secrets or proprietary information to ensure
that such employees, agents and consultants do not disclose or make any
unauthorized use of such Confidential Information. Each party will promptly
notify the other upon discovery of any unauthorized use or disclosure of
Confidential Information.

         5.2 EXCEPTIONS. The obligations of confidentiality contained in
Section 5.1 will not apply to the extent that it can be established by the
receiving party by competent proof that such Confidential Information:

                  (a) was already known to the receiving party, other than
under an obligation of confidentiality, at the time of disclosure by the
other party;

                  (b) was generally available to the public or otherwise part
of the public domain at the time of its disclosure by the other party;

                  (c) became generally available to the public or otherwise
part of the public domain after its disclosure and other than through any act
or omission of the receiving party in breach of this Agreement; or

                  (d) was disclosed to the receiving party, other than under
an obligation of confidentiality, by a Third Party who had no obligation to
the other party not to disclose such information to others.

         5.3 AUTHORIZED DISCLOSURE. Each party may disclose the Confidential
Information to the extent such disclosure is reasonably necessary to file or
prosecute patent applications, to prosecute or defend litigation or to comply
with applicable governmental regulations; PROVIDED, HOWEVER, that if such
party is required to make any such disclosure of Confidential Information it
will to the extent practicable give reasonable advance notice to the other
party of such disclosure requirement and, except to the extent inappropriate
in the case of patent applications, will use its best efforts to secure
confidential treatment of such information required to be disclosed.

         5.4 PUBLICATION. During the Term, the Foundation and the Company
each acknowledge the other party's interest in publishing certain of its
results to obtain recognition within the scientific community and to advance
the state of scientific knowledge. Each party also recognizes the mutual
interest in obtaining valid patent protection and maintaining as confidential
any non-patentable methods which would have commercial value when
undisclosed. Consequently, either party, its employees or consultants wishing
to make a publication (including any oral disclosure made without obligation
of confidentiality) relating to the Licensed Technology (the "Publishing
Party") shall transmit to the other party (the "Reviewing Party") a copy of
the proposed written publication at least 60 days prior to submission for
publication, or an outline of such oral disclosure at least 30 days prior to
presentation. The Reviewing Party shall have the right (a) to propose
modifications to the publication for patent protection of trade secret or
other reasons and (b) to request a delay in publication in order to protect
patentable information. If the Reviewing Party requests such a delay, the
Publishing

                                      6.

<PAGE>

Party shall delay submission or presentation of the publication for a period
of 90 days to enable patent applications protecting each party's rights in
such information to be filed. If the Reviewing Party reasonably claims that
such information, whether or not patentable, may have significant commercial
value and can be maintained as a trade secret, the Publishing Party shall
publish or disclose only such information which would not adversely affect
such commercial value. Upon the expiration of 60 days or 30 days from
transmission to the Reviewing Party, the Publishing Party shall be free to
proceed with the written publication or the presentation, respectively,
unless the Reviewing Party has requested the delay described above.
Notwithstanding the foregoing, the Foundation hereby agrees that it will not
publish Allyn Forsyth's thesis until patents have issued worldwide on all
patent applications within the Patent Rights.

                                    ARTICLE 6
                          INTELLECTUAL PROPERTY RIGHTS

         6.1 OWNERSHIP. Ownership of inventions shall be determined in
accordance with the rules of inventorship under United States patent law. The
Company shall have sole ownership of all inventions, discoveries,
developments and improvements conceived of and reduced to practice solely by
its employees or agents, and all patent applications and patents claiming
such inventions, discoveries, developments and improvements. The Foundation
shall have sole ownership of all Licensed Technology and all inventions,
discoveries, developments and improvements conceived of and reduced to
practice solely by its employees and agents, and all patent applications and
patents claiming such inventions, discoveries, developments and improvements.
All inventions conceived of and reduced to practice jointly by employees or
agents of the Company and employees or agents of the Foundation, and all
patent applications and patents claiming such inventions, discoveries,
developments and improvements, shall be owned jointly by the Company and the
Foundation.

         6.2 APPLICATION, PROSECUTION AND MAINTENANCE OF PATENT RIGHTS. From
and after the Effective Date, the Company shall, at its expense, be
responsible for filing, prosecuting and maintaining patents and/or patent
applications worldwide for those inventions covered by the Patent Rights or
any Future Inventions. The Company will keep the Foundation advised of the
status of the filing, prosecution and maintenance of the Patent Rights and/or
any Future Inventions and will provide to the Foundation copies of official
actions, amendments and responses with respect to such filing, prosecution
and maintenance. In the event that the Company desires to abandon any Patent
Rights or Future Inventions, or if the Company later declines responsibility
for any Patent Rights or Future Inventions, the Company shall provide
reasonable prior written notice to the Foundation of such intention to
abandon or decline responsibility, and the Foundation shall have the right,
at its expense, to file, prosecute, and maintain such Patent Rights or Future
Inventions.

         6.3 INFRINGEMENT BY THIRD PARTIES. The Company and the Foundation
shall promptly notify the other in writing of any alleged or threatened
infringement of any patent or patent application covered by the Patent Rights
or any Future Inventions of which they become aware. Both parties shall use
their best efforts in cooperating with each other to terminate such

                                      7.

<PAGE>

infringement without litigation. The Company shall have the first right to
bring and control any action or proceeding with respect to such infringement,
at its own expense and by counsel of its own choice, and the Foundation shall
have the right, at its own expense, to participate in such action by counsel
of its own choice if there are claims or defenses which are not shared with
the Company, or if the Company fails to prosecute or raise claims or defenses
that are shared by the Company and the Foundation. If the Company fails to
bring an action or proceeding within (a) 90 days following the notice of
alleged infringement or (b) 10 days before the time limit, if any, set forth
in the appropriate laws and regulations for the filing of such actions,
whichever comes first, the Foundation shall have the right to bring and
control any such action, at its own expense and by counsel of its own choice,
and the Company shall have the right, at its own expense, to be represented
in any such action by counsel of its own choice. In the event a party brings
an infringement action, the other party shall cooperate fully, including if
required to bring such action, the furnishing of a power of attorney. Neither
party shall have the right to settle any patent infringement litigation under
this Section 6.3 in a manner that diminishes the rights or interests of the
other party without the consent of such other party. Except as otherwise
agreed to by the parties as part of a cost sharing arrangement, any recovery
realized as a result of such litigation, after reimbursement of any
litigation expenses of the Company and the Foundation, shall belong to the
party who brought the action.

         6.4 INFRINGEMENT OF THIRD PARTY RIGHTS. The Company and the
Foundation shall promptly notify the other in writing of any allegation by a
Third Party that the exercise of the rights granted to the Company under this
Agreement infringes or may infringe the intellectual property rights of such
Third Party. The Company shall have the first right to control any defense of
such claim, at its own expense and by counsel of its own choice, and the
Foundation shall have the right, at its own expense, to participate in such
action by counsel of its own choice if there are counterclaims or defenses
which are not shared with the Company, or if the Company fails to prosecute
or raise counterclaims or defenses that are shared by the Company and the
Foundation. If the Company fails to proceed in a timely fashion with regard
to such defense, the Foundation shall have the right to control any such
defense of such claim at its own expense and by counsel of its own choice,
and the Company shall have the right, at its own expense, to be represented
in any such action by counsel of its own choice. Neither party shall have the
right to settle any patent infringement litigation under this Section 6.4 in
a manner that diminishes the rights or interests of the other party or
obligates the other party to make any payment or take any action without the
consent of such other party.

                                    ARTICLE 7
                    REPRESENTATIONS, WARRANTIES AND COVENANTS

         7.1 CORPORATE POWER. Each party hereby represents and warrants that
it is duly organized and validly existing under the laws of the state of its
incorporation and has full corporate power and authority to enter into this
Agreement and to carry out the provisions hereof.

         7.2 DUE AUTHORIZATION. Each party hereby represents and warrants
that such party is duly authorized to execute and deliver this Agreement and
to perform its obligations hereunder.

                                      8.

<PAGE>

         7.3 BINDING AGREEMENT. Each party hereby represents and warrants
that this Agreement is a legal and valid obligation binding upon it and is
enforceable in accordance with its terms. The execution, delivery and
performance of this Agreement by such party does not conflict with any
agreement, instrument or understanding, oral or written, to which it is a
party or by which it may be bound, nor violate any law or regulation of any
court, governmental body or administrative or other agency having authority
over it.

         7.4 OWNERSHIP OF PATENT RIGHTS. The Foundation represents and
warrants that (a) it is the sole owner of all right, title and interest in
and to the Patent Rights, (b) it has not granted any license under the Patent
Rights to any Third Party and is under no obligation to grant any such
license except to the Company, and (c) there are no outstanding liens,
encumbrances, agreements or understandings of any kind, either written, oral
or implied, regarding the Patent Rights which are inconsistent or in conflict
with this Agreement.

         7.5 PATENT PROCEEDINGS. The Foundation represents and warrants that,
to the best of its knowledge, no patent application within the Patent Rights
is the subject of any pending interference, opposition, cancellation or other
protest proceeding.

         7.6 DUE DILIGENCE. The Company agrees to use commercially reasonable
efforts to commercialize the Licensed Technology. If the Foundation believes
that the Company is not pursuing this objective, then the Foundation may seek
resolution according to Article 9 of this Agreement.

         7.7 DISCLAIMER OF WARRANTIES. EXCEPT AS EXPRESSLY SET FORTH IN THIS
AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY TO THE OTHER
PARTY OF ANY NATURE, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY
WARRANTY OF NON-INFRINGEMENT, MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE.

         7.8 INDEMNIFICATION BY THE COMPANY. The Company hereby agrees to
save, defend and hold harmless the Foundation and its trustees, officers,
employees, students and agents from and against any and all suits, claims,
actions demands, liabilities, expenses and losses, including reasonable legal
expense and attorneys' fees ("Losses"), arising directly or indirectly the
breach of any representation or warranty made by the Company hereunder or out
of the practice by the Company of the license granted hereunder, except to
the extent such Losses result from the negligence or the willful misconduct
of the Foundation. In the event the Foundation seeks indemnification under
this Section 7.8, the Foundation shall inform the Company of a claim as soon
as reasonably practicable after the Foundation receives notice of the claim,
shall permit the Company to assume direction and control of the defense of
the claim (including the right to settle the claim solely for monetary
consideration), and shall cooperate as requested (at the expense of the
Company) in the defense of the claim.

         7.9 INDEMNIFICATION BY THE FOUNDATION. The Foundation hereby agrees
to save, defend and hold harmless the Company from and against any and all
Losses arising directly or indirectly out of the breach of any representation
or warranty made by the Foundation hereunder,

                                      9.

<PAGE>

except to the extent such Losses result from the negligence or the willful
misconduct of the Company. In the event the Company seeks indemnification
under this Section 7.9, the Company shall inform the Foundation of a claim as
soon as reasonably practicable after the Company receives notice of the
claim, shall permit the Foundation to assume direction and control of the
defense of the claim (including the right to settle the claim solely for
monetary consideration), and shall cooperate as requested (at the expense of
the Foundation) in the defense of the claim.

                                    ARTICLE 8
                                TERM; TERMINATION

         8.1 TERM. The term of this Agreement (the "Term") shall begin on the
Effective Date and shall end on the expiration of the last to expire of the
issued patents under the Licensed Technology or, if no patent issues under
the Licensed Technology, 15 years after the Effective Date, unless terminated
earlier in accordance with the terms of this Agreement. Following the
expiration of this Agreement in accordance with this Section 8.1, the Company
shall have a license on the same terms as set forth in Section 2.1, except
that the license shall be a non-exclusive, fully-paid, irrevocable license.

         8.2 TERMINATION. Either party may terminate this Agreement prior to
the expiration of the Term upon the occurrence of any of the following:

                  (a) Upon or after the bankruptcy, insolvency, dissolution
or winding up of the other party (other than dissolution or winding up for
the purposes of reconstruction or amalgamation); or

                  (b) Upon or after the breach of any material provision of
this Agreement by the other party if the breaching party has not cured such
breach within 60 days after written notice thereof by the other party.

         8.3 EFFECT OF TERMINATION. Upon any termination of this Agreement by
the Foundation pursuant to Section 8.2, all rights to the Licensed Technology
will revert to the Foundation. Upon any termination of this Agreement by the
Company pursuant to Section 8.2, the license granted under Section 2.1 shall
remain in effect so long as the Company does not breach its obligations to
the Foundation under this Agreement. Expiration or termination of this
Agreement shall not relieve the parties of any obligation accruing prior to
such expiration or termination. The provisions of Sections 2.3, 4.3, 6.1,
7.7, 7.8, 7.9 and 8.3 and Articles 5, 9 and 10 shall survive termination or
expiration of this Agreement.

                                    ARTICLE 9
                               DISPUTE RESOLUTION

         9.1 DISPUTES. The parties recognize that disputes as to certain
matters may from time to time arise which relate to either party's rights
and/or obligations hereunder. It is the objective of the parties to establish
procedures to facilitate the resolution of such disputes in an expedient

                                      10.

<PAGE>

manner by mutual cooperation and without resort to litigation. To accomplish
this objective, the parties agree to follow the procedures set forth in this
Article 9 if and when such a dispute arises between the parties.

         9.2 PROCEDURE. If a dispute arises between the parties relating to
the interpretation or performance of this Agreement or the grounds for the
termination thereof, and the parties cannot resolve the dispute within 30
days of a written request by either party to the other, the parties agree to
hold a meeting, attended by individuals with decision-making authority
regarding the dispute, to attempt in good faith to negotiate a resolution of
the dispute prior to pursuing other available remedies. If, within 30 days
after such meeting, the parties have not succeeded in negotiating a
resolution of the dispute, such dispute shall be submitted to final and
binding arbitration under the then current commercial rules and regulations
of the American Arbitration Association ("AAA") relating to voluntary
arbitrations in San Diego, California. The arbitration shall be conducted by
one arbitrator, who is knowledgeable in the subject matter at issue in the
dispute and who will be selected by mutual agreement of the parties or,
failing such agreement, shall be selected in accordance with the AAA rules.
Each party shall initially bear its own costs and legal fees associated with
such arbitration. The prevailing party in any such arbitration shall be
entitled to recover from the other party the reasonable attorneys' fees,
costs and expenses incurred by such prevailing party in connection with such
arbitration. The decision of the arbitrator shall be final and may be sued on
or enforced by the party in whose favor it runs in any court of competent
jurisdiction.

                                   ARTICLE 10
                                  MISCELLANEOUS

         10.1 RIGHTS OF U.S. GOVERNMENT. The U.S. Government shall have a
worldwide, non-exclusive, nontransferable, irrevocable, paid-up license to
practice or have practiced for or on behalf of the United States the Licensed
Technology.

         10.2 FORCE MAJEURE. Neither party shall be held liable or
responsible to the other party nor be deemed to have defaulted under or
breached this Agreement for failure or delay in fulfilling or performing any
term of this Agreement when such failure or delay is caused by or results
from causes beyond the reasonable control of the affected party, including,
without limitation, fire, floods, embargoes, war, acts of war (whether war be
declared or not), insurrections, riots, civil commotions, strikes, lockouts
or other labor disturbances, acts of God or acts, omissions or delays in
acting by any governmental authority or the other party.

         10.3 ASSIGNMENT. This Agreement may not be assigned or otherwise
transferred, nor, except as expressly provided hereunder, may any right or
obligations hereunder be assigned or transferred, by either party without the
written consent of the other party; PROVIDED, HOWEVER, that either party may,
without such consent, assign this Agreement and its rights and obligations
hereunder (a) in connection with the transfer or sale of all or substantially
all of its business, if such assets include substantially all of the assets
relating to its performance of its respective obligations hereunder, (b) to
an Affiliate or (c) in the event of its merger or consolidation with another
company at any time during the term of this Agreement. Any purported
assignment in

                                      11.

<PAGE>

violation of this Section 10.3 shall be void. The rights and obligations of
the parties under this Agreement will be binding upon the heirs, successors
and permitted assigns of the parties.

         10.4 PUBLICITY. The parties agree that neither party will originate
any press release or other public announcement, written or oral, or otherwise
make any disclosure relating to the existence or terms of or performance
under this Agreement without the prior written approval of the other party,
except as may otherwise be required by law.

         10.5 SEVERABILITY. In case any provision of this Agreement shall be
invalid, illegal or unenforceable, the validity, legality and enforceability
of the remaining provisions shall not in any way be affected or impaired
thereby.

         10.6 NOTICES. Any notices or communications provided for in this
Agreement to be made by either of the parties to the other shall be in
writing and delivered personally or sent by United States mail, registered or
certified, postage paid, by overnight delivery service such as FedEx or UPS
or by facsimile, with confirmation of receipt, addressed as follows:

         IF TO THE COMPANY:        RAJYABIOTICS
                                   8415 La Jolla Scenic Drive
                                   San Diego, CA  92037
                                   Attn: Judith W. Zyskind, Ph.D.
                                   Phone No. (619) 594-6597
                                   Fax No. (619) 594-0355

         IF TO THE FOUNDATION:     SAN DIEGO STATE UNIVERSITY FOUNDATION
                                   5250 Campanile Drive
                                   San Diego, CA 92182-1934
                                   Attn: Frank J. DiSanto, Director
                                         Grants and Contracts Administration
                                   Phone No. (619) 594-1052
                                   Fax No. (619) 594-4950

         Either party may by like notice specify or change an address to
which notices and communications shall thereafter be sent. Notices sent by
facsimile shall be effective upon confirmation of receipt, notices sent by
mail or overnight delivery service shall be effective upon receipt, and
notices given personally shall be effective when delivered.

         10.7 GOVERNING LAW. This Agreement shall be governed by, and
construed and enforced in accordance with, the laws of the State of
California, without regard to its choice of law provisions, and any
applicable laws of the United States.

         10.8 ENTIRE AGREEMENT; AMENDMENT. This Agreement sets forth all of
the covenants, promises, agreements, warranties, representations, conditions
and understandings between the parties hereto with respect to the subject
matter of this Agreement, and supersedes and terminates all prior agreements
and understanding between the parties with respect to the subject matter of
this Agreement. There are no covenants, promises, agreements, warranties,
representations

                                      12.

<PAGE>

conditions or understandings with respect to the subject matter hereof,
either oral or written, between the parties other than as set forth herein.
No subsequent alteration, amendment, change or addition to this Agreement
shall be binding upon the parties hereto unless reduced to writing and signed
by the respective authorized officers of the parties.

         10.9 HEADINGS. The captions contained in this Agreement are not a
part of this Agreement, but are merely guides or labels to assist in locating
and reading the several Articles hereof.

         10.10 INDEPENDENT CONTRACTORS. It is expressly agreed that the
Foundation and the Company shall be independent contractors and that the
relationship between the two parties shall not constitute a partnership,
joint venture or agency of any kind. Neither party shall have the authority
to make any statements, representations or commitments of any kind, or to
take any action, which shall be binding on the other, without the prior
written consent of the other party.

         10.11 WAIVER. Except as specifically provided for herein, the waiver
from time to time by either of the parties of any of their rights or their
failure to exercise any remedy shall not operate or be construed as a
continuing waiver of the same rights or remedies or of any other of such
party's rights or remedies provided in this Agreement.

         10.12 COUNTERPARTS. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

                                      13.

<PAGE>

         IN WITNESS WHEREOF, the parties have executed this
Agreement as of the date first set forth above.

RAJYABIOTICS

By: /s/ Judith Zyskind
   -------------------------------------------------

Name: Judith W. Zyskind
     -----------------------------------------------

Title: President
      ----------------------------------------------

SAN DIEGO STATE UNIVERSITY FOUNDATION

By: /s/ Frank J. DiSanto
   -------------------------------------------------

Name: Frank J. DiSanto
     -----------------------------------------------

Title: Director, Grants & Contracts
      ----------------------------------------------

THE UNDERSIGNED ACKNOWLEDGES AND AGREES TO THE PROVISIONS
OF SECTION 2.3 OF THIS AGREEMENT:

SAN DIEGO STATE UNIVERSITY

By: /s/ James W. Cobble
   -------------------------------------------------

Name: James W. Cobble
     -----------------------------------------------

Title: Dean of the Graduate Division and Vice
       President for Research
      ----------------------------------------------

                               LICENSE AGREEMENT

<PAGE>

                                    EXHIBIT A

                                  PATENT RIGHTS

All subject matter disclosed and/or claimed in U.S. Patent Application No.
[... *** ...] filed [... *** ...], entitled [... *** ...].

                                           *CONFIDENTIAL TREATMENT REQUESTED

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00014-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00014-of-00352.parquet"}]]