Document:

EX-10.36

 Exhibit 10.36 
 FOURTH AMENDMENT TO 
 AMENDED AND RESTATED EMPLOYMENT AGREEMENT

 THIS FOURTH AMENDMENT TO EMPLOYMENT AGREEMENT (this “Agreement”), is entered into
as of the 14th day of December 2012 (the “Effective
Date”) by and between BRETT D. NICHOLAS (the “Executive”) and REDWOOD TRUST, INC., a Maryland Corporation (the “Company”). 
 WHEREAS, the Executive and the Company have entered into an Amended and Restated Employment Agreement dated as of March 31, 2009 (as subsequently amended as of March 17,
2010, February 24, 2011, and May 17, 2012, the “Employment Agreement”); and 
 WHEREAS, the
Executive and the Company desire to enter into this Agreement for purposes of amending the Employment Agreement as set forth herein; 
 NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy which is hereby acknowledged, the Executive and the Company hereby agree that the Employment Agreement is hereby
amended as follows effective upon the Effective Date: 
  

	 	(1)	As of January 1, 2013, Section 3(a) of the Employment Agreement shall be amended to replace the base salary amount of “$500,000” specified therein
with “$575,000”. 

  

	 	(2)	Section 7(c) of the Employment Agreement shall be amended and restated to read in its entirety as follows: 

“Release Agreement.  As a condition of receiving any of the payments and benefits set forth in this Section 7,
the Executive shall be required to execute a mutual release agreement in the form attached hereto as Exhibit C or Exhibit D, as appropriate, and such release agreement must have become effective in accordance with its terms within 75 days following
the termination date. The Company, in its sole discretion, may modify the term of the required release agreement to comply with applicable state law and may incorporate the required release agreement into a termination agreement or other agreement
with the Executive.” 
 Except as hereby specifically amended or modified, the terms of the Employment Agreement, as amended by this
Agreement, shall remain in full force and effect. This Agreement may be executed by the parties hereto in two counterparts, each of which shall be an original and all of which together shall constitute one and the same agreement. This
Agreement shall be governed in all respects by the laws of the State of California (without regard to conflict of law principles). 
 IN WITNESS WHEREOF, the Company has caused this Agreement to be executed by its duly authorized officer, and the Executive has executed this Agreement, as of the date first above written.

  

									
		 		 	REDWOOD TRUST, INC.	 	
					
		 		 	By:	 	 /s/ Martin S. Hughes
	 	
		 		 		 	Name: Martin S. Hughes	 	
		 		 		 	Title: Chief Executive Officer	 	
				
		 		 	BRETT D. NICHOLAS	 	
					
		 		 		 	 /s/ Brett D. NicholasEX-10.37

 Exhibit 10.37 
 THIRD AMENDMENT TO 
 AMENDED AND RESTATED EMPLOYMENT AGREEMENT

 THIS THIRD AMENDMENT TO EMPLOYMENT AGREEMENT (this “Agreement”), is entered into as of the 14th day of
December 2012 (the “Effective Date”) by and between HAROLD F. ZAGUNIS (the “Executive”) and REDWOOD TRUST, INC., a Maryland Corporation (the “Company”). 

WHEREAS, the Executive and the Company have entered into an Amended and Restated Employment Agreement dated as of March 31,
2009 (as subsequently amended as of February 24, 2011 and May 17, 2012, the “Employment Agreement”); and 

WHEREAS, the Executive and the Company desire to enter into this Agreement for purposes of amending the Employment Agreement as
set forth herein; 
 NOW, THEREFORE, for good and valuable consideration, the receipt and adequacy which is hereby
acknowledged, the Executive and the Company hereby agree that the Employment Agreement is hereby amended as follows effective upon the Effective Date: 
 (1) Section 7(c) of the Employment Agreement shall be amended and restated to read in its entirety as follows: 
 “Release Agreement.  As a condition of receiving any of the payments and benefits set forth in this Section 7, the Executive shall be required to execute a mutual release
agreement in the form attached hereto as Exhibit C or Exhibit D, as appropriate, and such release agreement must have become effective in accordance with its terms within 75 days following the termination date. The Company, in its sole discretion,
may modify the term of the required release agreement to comply with applicable state law and may incorporate the required release agreement into a termination agreement or other agreement with the Executive.” 

Except as hereby specifically amended or modified, the terms of the Employment Agreement, as amended by this Agreement, shall remain in
full force and effect. This Agreement may be executed by the parties hereto in two counterparts, each of which shall be an original and all of which together shall constitute one and the same agreement. This Agreement shall be governed in
all respects by the laws of the State of California (without regard to conflict of law principles). 
 IN WITNESS
WHEREOF, the Company has caused this Agreement to be executed by its duly authorized officer, and the Executive has executed this Agreement, as of the date first above written. 

 

									
		 		 	REDWOOD TRUST, INC.	 	
					
		 		 	By:	 	 /s/ Martin S. Hughes
	 	
		 		 		 	Name: Martin S. Hughes	 	
		 		 		 	Title: Chief Executive Officer	 	
				
		 		 	HAROLD F. ZAGUNIS	 	
					
		 		 		 	 /s/ Harold F. ZagunisEX-10.60

 Exhibit 10.60 

EXECUTION COPY 
 CONFIDENTIAL TREATMENT REQUESTED 
 Redacted portions are indicated
by [****]. 
 Redacted portions filed separately with 

Confidential Treatment Application. 
 SECOND AMENDMENT TO 
 STOCK PURCHASE AGREEMENT 

THIS SECOND AMENDMENT TO STOCK PURCHASE AGREEMENT (this “Amendment 2”) is effective as of October 26, 2012 and
amends that certain Stock Purchase Agreement, dated as of October 20, 2009 (the “Agreement”) as previously amended March 26, 2010 (“Amendment 1”), by and among BioMarin Pharmaceutical Inc., a Delaware
corporation (the “Purchaser”), Huxley Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and the stockholders of the Company party thereto (collectively, the “Stockholders”). 

RECITALS 

A.    WHEREAS, pursuant to the Agreement, the Stockholders sold, assigned, transferred and delivered to the
Purchaser, and the Purchaser purchased and acquired from the Stockholders, all right, title and interest in and to all of the issued and outstanding shares of capital stock of the Company (the “Acquisition”); 

B.    WHEREAS, pursuant to Section 12.3 of the Agreement, the Agreement may not be amended, modified or
supplemented except by written agreement between the Purchaser and the Stockholder Representative (as defined below); and 

C.    WHEREAS, the Purchaser and Aceras BioMedical, LLC, in its capacity as the Stockholder Representative (the
“Stockholder Representative”), desire to modify the Agreement as set forth in this Amendment 2. 
 NOW,
THEREFORE, in consideration of the foregoing, the parties hereto hereby agree as follows: 
  

	 	1.	The last sentence of the first paragraph of Section 1.4 of the Agreement, shall be deleted in its entirety and replaced with the following new sentence:

  

	 	    	 Notwithstanding anything to the contrary contained herein, the Purchaser’s obligation to make any payments to the Stockholders pursuant to this
Section 1.4 shall terminate on April 20th 2018.

  

	 	2.	Section 1.4, Section 1.4 (g), Section 1.4(h) and Section 5.11 (b) shall be revised as follows: 

 

	 	a.	Section 1.4(g) of the Agreement, previously amended by Amendment 1, shall be deleted in its entirety and replaced with the following new Section 1.4(g):

 EXECUTION COPY 

(g) [****] 

 

	 	b.	Section 1.4(h) of the Agreement, previously amended by Amendment 1, shall be deleted in its entirety and replaced with the following new Section 1.4(h):

 (h) [****] 

 

	 	c.	The paragraph at the end of Section 1.4 of the Agreement, previously amended by Amendment 1, shall be deleted in its entirety and replaced with the following new
paragraph: 

 [****] 
  

	 	d.	Section 5.11(b) of the Agreement is hereby amended by adding the following as a new clause (iii): 

  

	[****] =	Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with The Securities and Exchange Commission
pursuant to Rule 24b-2 of the Securities and Exchange Act of 1934, as amended. 

 “(iii) The Stockholders acknowledge that, pursuant to a License Agreement dated as of
October 26, 2012 (the “License Agreement”) between the Purchaser and Catalyst Pharmaceutical Partners, Inc. (“Catalyst”), the Purchaser has granted a right to Catalyst to develop, manufacture, sell, market, distribute and/or
promote a Product in the United States, Canada and Mexico (collectively, the “Territory”). The Stockholders hereby agree that, notwithstanding anything to the contrary herein, but without limiting Section 5.11(b)(ii) with respect to
any country in the world outside the Territory, no Stockholder shall, during the term of the License Agreement, in any manner, either directly, indirectly, individually, in partnership, jointly or in conjunction with any Person, (A) engage in a
Competing Business (as defined below) anywhere in the Territory, or (B) have an equity or profit interest in, advise or render services related to a Competing Business (of an executive, marketing, manufacturing, research and development,
administrative, financial, consulting or other nature) or lend money to any Person that engages in a Competing Business anywhere in the Territory; provided, however, that notwithstanding the foregoing, each Stockholder may (1) hold,
purchase or otherwise acquire up to but not more than five (5%) in the aggregate of any class of equity securities of any Person, including without limitation, a Person engaged in a Competing Business, if (i) such securities are listed on
any national securities exchange and (ii) such Stockholder is not otherwise involved or associated, directly or indirectly, with the operation of the issuer of such securities (2) continue to own securities in other Entities acquired prior
to the date of this Agreement and (3) engage in any activities related to a Licensed Compound or Competing Business (as defined below), as permitted in writing in advance by Catalyst. For purposes of this Section 5.11(b)(iii), the term
“Competing Business” means developing (including researching and seeking regulatory approval) and/or commercialization (including distributing) of any product containing Licensed Compound for any indication or developing and/or
commercialization of any other amino pyridine for the treatment of any neuro-muscular disease, and the term “Licensed Compound” means 3,4-diaminopyridine and any derivatives, isomers, metabolites, prodrugs, acid forms, base forms, salt
forms, or modified versions of 3,4-diaminopyridine. Catalyst hereby is and shall be a named third party beneficiary of this Section 5.11(b)(iii), with all rights to enforce the terms of this Section 5.11(b)(iii) against the Stockholders;
provided, that except as otherwise set forth in this Section 5.11(b)(iii), Catalyst shall have no rights or remedies arising out of or with respect to the Agreement. The Stockholders acknowledge and agree that the restrictions set forth in this
Section 5.11(b)(iii) are reasonable and necessary to protect the legitimate interests of Catalyst and that any breach or threatened breach of this Section 5.11(b)(iii) may result in irreparable injury to Catalyst for which there may be no
adequate remedy at law. In the event of a breach or threatened breach of this Section 5.11(b)(iii) by any Stockholder, Catalyst shall be authorized and entitled to obtain from any court of competent jurisdiction injunctive relief, whether
preliminary or permanent, specific performance, and an equitable accounting of all earnings, profits, and other benefits arising from such breach, which rights shall be cumulative and in addition to any other rights or remedies to which Catalyst may
be entitled in law or equity. The Stockholders agree to waive any requirement that Catalyst post a bond or other security as a condition for obtaining any such relief or show irreparable harm, balancing of harms, consideration of the public
interest, or inadequacy of monetary damages as a remedy.” 

 EXECUTION COPY 
 The amendments agreed to in this Paragraph 2 of this Amendment 2 are solely agreed to upon and in conjunction with the execution of the License Agreement (as defined above), and if such License Agreement
is not executed or is terminated, then the amendments agreed to in this Paragraph 2 will no longer be valid or in force; provided, that, if the License Agreement is terminated, any payment obligations arising out of this Amendment 2 that accrued
prior to any such termination shall survive such termination. 
  

	 	3.	Section 5.13 of the Agreement is hereby amended by adding the following sentence: 

“The Purchaser shall provide the Stockholder Representative with an executed copy of the License Agreement. The Purchaser shall not
agree to amend, modify or waive any of the terms of the License Agreement in a manner that materially and adversely affects the Stockholders, including their right to receive amounts that may become due under Section 1.4 hereof, without the
prior written consent of the Stockholder Representative. The Purchaser shall provide the Stockholder Representative with copies of the Development Plan and Development Reports provided to the Purchaser by Catalyst.” 

 

	 	4.	The definition of “Sublicensee” in Exhibit A of the Agreement shall be deleted in its entirety and replaced with the following new definition:

 “’Sublicensee’ means an Entity to whom a party, or a direct or indirect sublicensee of a
party, has granted a right to develop, manufacture, sell, market, distribute and/or promote a Product.” 
  

	 	5.	The Purchaser shall pay to the Stockholders [****] of any consideration that may be received by the Purchaser or its Affiliates as a result of any grant of rights,
license, sublicense, sale or other disposition of a Product, including the License Agreement and any subsequent amendment to the License Agreement, until such time as Stockholders have received cumulative payments of [****] excluding any payments to
be made under Section 1.4 of the Agreement; provided, however, that such consideration shall not include [****]. All payments under this Section 5 shall be made to the Stockholders in U.S. dollars within thirty (30) days after
receipt by Purchaser. The Purchaser shall submit with each such payment a statement reflecting the calculation of the amount paid to the Stockholders. 

  

	[****] =	Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with The Securities and Exchange Commission
pursuant to Rule 24b-2 of the Securities and Exchange Act of 1934, as amended. 

 EXECUTION COPY 

 

	 	6.	Capitalized terms used in this Amendment 2 but not otherwise defined herein shall have the meanings set forth in the Agreement. 

 

	 	7.	Except as expressly set forth in this Amendment 2, all other terms of the Agreement shall remain in full force and effect and once this Amendment 2 is executed by the
parties hereto, all references in the Agreement to “the Agreement” or “this Agreement,” as applicable, shall refer to the Agreement, as modified by this Amendment 2. 

 

	 	8.	This Amendment 2 and the relationship of the parties hereto shall be construed in accordance with, and governed in all respects by, the internal laws of the State of
New York (without giving effect to principles of conflicts of laws). 

  

	 	9.	This Amendment 2 will apply to, be binding in all respects upon and inure to the benefit of the successors and permitted assigns of the parties.

  

	 	10.	This Amendment 2 may be executed in several counterparts, each of which shall be deemed an original and all of which shall constitute one and the same instrument, and
shall become effective when counterparts have been signed by each of the parties and delivered to the other parties; it being understood that all parties need not sign the same counterparts. The exchange of copies of this Amendment 2 and of
signature pages by facsimile transmission (whether directly from one facsimile device to another by means of a dial-up connection or whether mediated by the worldwide web), by electronic mail in “portable document format”
(“.pdf”) form, or by any other electronic means intended to preserve the original graphic and pictorial appearance of a document, or by combination of such means, shall constitute effective execution and delivery of this Amendment 2 as to
the parties and may be used in lieu of the original Amendment 2 for all purposes. Signatures of the parties transmitted by facsimile or other electronic means shall be deemed to be their original signatures for all purposes.

 [Signature Page Follows] 

 IN WITNESS WHEREOF, the parties hereto have executed and delivered this Amendment 2 as of
the date first above written. 
  

									
	PURCHASER:	 		 	BIOMARIN PHARMACEUTICAL INC.
				
		 		 	By:	 	/s/ G. Eric. Davis
		 		 		 	Name:	 	G. Eric Davis
		 		 		 	Title:	 	SVP, General Counsel
			
	STOCKHOLDER REPRESENTATIVE:	 		 	 ACERAS BIOMEDICAL, LLC
 On Behalf of Itself and for All Stockholders

				
		 		 	By:	 	/s/ John Liatos
		 		 		 	Name:	 	John Liatos
		 		 		 	Title:	 	Managing Member
			
	 AS THIRD PARTY BENEFICIARY
 OF
SECTION 5.11(b)(iii), AS
 AMENDED HEREBY:
	 		 	CATALYST PHARMACEUTICAL PARTNERS, INC.
				
		 		 	By:	 	/s/ Patrick J. McEnany
		 		 		 	Name:	 	Patrick J. McEnany
		 		 		 	Title:	 	Chairman, President & CEO

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