Document:

Unassociated Document

     

    Exhibit
      10.18

    
 

    RESEARCH
      & DEVELOPMENT AGREEMENT

    SECOND
      AMENDMENT

     

    
 

    Between:

     

    
 

    Roche
      Diagnostics GmbH

    Sandhofer
      Strasse 16

    68305
      Mannheim

    Federal
      Republic of Germany

    

    (hereinafter
      referred to as “RDG”)

     

    
 

    and

     

    
 

    CombiMatrix
      Corporation

    6500
      Harbour Heights Pkwy.

    Mukilteo,
      WA 98275

    USA

    

    -  hereinafter
      referred as to “CBMX”

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    WHEREAS,
      the Parties wish to amend their R&D Agreement dated September 25th
      2002 as
      amended on March 25th
      2003 as
      follows:

    

    A
      New
      Article, 4A, shall be inserted in between Section 4.3 and Section 5 as
      follows:

    

    “4A.
      COMPLETION OF DEVELOPMENT PROGRAM

    

    As
      of
      December 31st
      2003,
      RDG’s obligations to make any further payments under Article 4 herein and CBMX’s
      obligations to perform further R&D for RDG under Article 2 and Annex I of
      the Development Program are terminated. Therefore, as of 03 November 2003,
      there
      are no further obligations of either party resulting from the R&D Agreement
      to make any further payments or to perform any R&D services. As a result,
      the Development Program of Annex I of the R&D Agreement shall be terminated
      with the effect of December 31st
      2003.

     

     

    IN
      WITNESS WHEREOF
      the
      Parties hereto have signed this Second Amendment:

    

    
      	
              Penzberg,
                Germany, March 19, 2004

            	
              Mukilteo,
                Washington March 26, 2004

            
	 	 
	
              Roche
                Diagnostics GmbH

            	
              CombiMatrix
                Corporation

            
	 	 
	
              By:
                /s/ Volker Pfahlert

            	
              By:
                /s/ Amit Kumar

            
	
              Volker
                Pfahlert

            	
              Amit
                Kumar

            
	 	 
	
              i.V.

            	 
	 	 
	
              By:
                /s/ Stefan Willemsen

            	
              By:
                /s/ Scott Burrell

            
	
              Stefan
                Willemsen

            	
              Scott
                BurrellSublease Guarantee

    Exhibit
      10.19

     

    SUBLEASE
      GUARANTY

    

    

    THIS
      SUBLEASE GUARANTY (this "Guaranty") is dated as of Jane 15, 2005 (the "Effective
      Date"), and is executed by COMBIMATRIX, CORPORATION., a Delaware Corporation
      ("Guarantor") in favor of ACCUPATH DIAGNOSTIC LABORATORIES, INC., dba U.S.
      LABS,
      a California corporation in connection with that Certain Sublease Agreement
      (the
      "Sublease"), dated June 15, 2005, between ACCUPATH DIAGNOSTIC LABORATORIES,
      INC., DBA U.S. LABS, a California corporation ("Sublandlord") and COMBIMATRIX
      MOLECULAR DIAGNOSTICS, INC., a California corporation, ("Subtenant") for the
      Subleased Premises located at 310 Goddard Way, Suite 150, Irvine, California.
      The Sublease is subject to the terms, conditions and provisions of the Lease,
      as
      that term is defined in the Sublease. Sublandlord has requested that Guarantor
      guarantee the Sublease. Consequently, Guarantor hereby acknowledges that this
      Guaranty is being executed and delivered to Sublandlord as a material inducement
      to and in consideration of Sublandlord entering into the Sublease with Subtenant
      and that Sublandlord would not enter into the Sublease without the execution
      and
      delivery of this Guaranty. In consideration of Sublandlord's entering into
      the
      Sublease, Guarantor hereby agrees as follows;

     

    1.  
      Guarantor hereby guarantees the punctual payment by Subtenant of all rent,
      monies and charges payable under the Sublease incurred from and after the
      Effective Date until the and of the term of the Sublease and the prompt and
      complete performance of every covenant, condition and provision of the Sublease
      to be kept, observed or performed by Subtenant from and after the Effective
      Date. Guarantor shall indemnify, defend by counsel reasonably acceptable to
      Sublandlord and hold Sublandlord harmless from and against any claims, demands,
      liabilities, losses, costs, damages or expenses (including, without limitation,
      reasonable attorneys' fees) arising directly or indirectly out of any failure
      by
      Subtenant to pay any rent, monies or charges payable by Subtenant under the
      Sublease from and after the Effective Date or the failure by Subtenant to
      perform any of the terms, covenants, conditions or provisions of the Sublease
      to
      be observed or performed by Subtenant from and after the Effective Date. All
      payments to be made by Guarantor under this Guaranty shall be made without
      deduction or offset and shall be made immediately upon demand by
      Sublandlord.

     

    2.  
      Guarantor hereby expressly waives (i) notice of the acceptance of this Guaranty,
      (ii) and all notice of non-performance, non-payment or non-observance on the
      part of Subtenant of the terms, covenants regarding; Subtenant's payment
      obligations under the conditions and provisions of the Sublease, and (iii)
      notice of any adverse changes in the financial status of Subtenant or other
      facts which increase the risk of this Guaranty to Guarantor. Guarantor
      specifically agrees that this is a guarantee of payment of performance, not
      of
      collection or satisfaction of judgment. Guarantor hereby consents to any remedy
      pursued by Sublandlord or its successor-in-interest to enforce its rights under
      the Sublease, in whatever order such party may choose, including any remedies
      which may affect or destroy Guarantor's right of subrogation or the right of
      Guarantor to

     

     

    
      
        
        

      

      
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    proceed
      against Subtenant for reimbursement. Without limiting the generality of the
      foregoing, Guarantor hereby waives any rights Guarantor hereby waives any rights
      Guarantor may have under California Civil Code sections 2809, 2819, 2845, 2849
      and 2850, or any successor statutes. Other than the nonpayment of money,
      Sublandlord will provide Guarantor reasonable notice of non-performance or
      non-observance of the terms, covenants, conditions and provisions of the
      Sublease.

     

    3.  
      This
      Guaranty is absolute and unconditional and the obligations of Guarantor under
      this Guaranty shall not be released, discharged, mitigated, impaired or
      affected, except to the same extent as Subtenant's obligations have been
      affected by: (a) any extensions of time, indulgences or modifications which
      Sublandlord may extend to or make with Subtenant in respect of or in the
      performance of any of the obligations of Subtenant under any one or more of
      the
      provisions of the Sublease; (b) any waiver by or failure of Sublandlord to
      enforce any term, covenant, condition or provision of the Sublease; (c) any
      amendment, supplement, renewal or extension of the Sublease; (d) any assignment
      of the Sublease by Subtenant or by any trustee, receiver or liquidator of
      Subtenant; (e) any consent which. Sublandlord may give to any such assignment
      or
      to any other matter; or (f) the release, substitution or addition of any
      guarantor of or party to the Sublease.

     

    4.  
      Guarantor hereby waives any right to require Sublandlord to: (a) proceed against
      Subtenant or any other person or pursue any rights or remedies with respect
      to
      the Sublease before proceeding against Guarantor; (b) proceed against or exhaust
      any security of Subtenant held by Sublandlord; or (c) pursue any other remedy
      whatsoever in Sublandlord's power. Sublandlord shall have the right to enforce
      this Guaranty regardless of the acceptance of additional security from the
      Subtenant and regardless of the release or discharge of Subtenant by Sublandlord
      or by others or by operation of any law. Guarantor's obligations hereunder
      are
      independent of the obligations of Subtenant under the Sublease and a separate
      action or actions may be brought and prosecuted against Guarantor whether or
      not
      any action is brought against Subtenant or Subtenant is joined in any such
      action or actions.

     

    5.  
      Without
      limiting the generality of the foregoing, the liability of Guarantor under
      this
      Guaranty shall not be deemed to have been waived, released, discharged, impaired
      or affected by reason of the release or discharge of Subtenant in any
      receivership, bankruptcy, winding-up or other creditor's proceeding or the
      rejection, disaffirmance or disclaimer of Subtenant's obligations under the
      Sublease in any proceeding, and shall continue with respect to the periods
      prior
      thereto and thereafter, for and with respect to the term contemplated and
      expressed in the Sublease. If Subtenant's obligations under the Sublease are
      rejected in any bankruptcy, reorganization, or similar proceeding involving
      Subtenant, or if the Sublease and/or any interest of Subtenant is terminated
      as
      a result of or in any such proceeding whether by action of or on behalf of
      Sublandlord or Subtenant, then in either of such events, Guarantor hereby agrees
      to and hereby does Sublease and hire as of the effective date of such rejection
      or terminations, the Subleased Premises described in the Sublease, and
      Sublandlord hereby agrees to and hereby does demise and rent such Subleased
      Premises as of said time to Guarantor for

     

     

    
      
        
        

      

      
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    what
      would be, but for such rejection or termination, the remainder of the term
      of
      said Sublease, upon all of the provisions set forth in the Sublease, all of
      which Guarantor covenants and agrees to perform and comply with as though
      Guarantor were substituted for Subtenant as the Subtenant under the Sublease
      as
      of the time of such rejection or termination and as though the Sublease had
      not
      been so rejected or terminated but continued in full force and effect with
      Guarantor as Subtenant. In such event, Sublandlord will take all reasonable
      steps to assist or permit Guarantor to exercise its rights with respect to
      use
      and possession of the Premises. Notwithstanding anything to the contrary
      contained in this Section 5, any such demise of the Subleased Premises by
      Sublandlord to Guarantor shall be subject to the consent of the Lessor under
      the
      Lease and, if Lessor elects to recapture the Subleased Premises, the Sublease
      and this Guaranty shall be void and of no effect as of the effective date of
      such election of recapture.

     

    6.  The
      liability of
      Guarantor shall not be affected by any repossession of the Subleased Premises
      by
      Subtandlord, provided, however, that the net payments received by Sublandlord
      after deducting all reasonable costs and expenses of repossessing and/or
      reletting the same, shall be credited from time to time by Sublandlord
      to the account of the Guarantor and Guarantor shall pay any balance owing to
      Sublandlord from time to time, immediately upon demand by Sublandlord. Upon
      repossession, Sublandlord shall take reasonable steps to mitigate its damages
      and costs.

     

    7.  No
      action
      or proceeding brought or instituted under this Guaranty and no recovery in
      pursuance
      thereof shall be a bar or defense to any further action or proceeding which
      may
      be brought under this Guaranty by reason of any further default or defaults
      hereunder and/or under the Sublease.

     

    8.  Guarantor
      hereby waives and agrees not to assert or take advantage of: (a) the defense
      of
      any statute of limitations in any action under or related to this Guaranty
      or
      the Sublease; (b) any right or defense that may arise by reason of the
      incapacity, lack of authority, death or disability of Subtenant or any other
      person; (c) any and all defenses based upon an election of remedies by
      Sublandlord which limits or destroys any subrogation rights Guarantor might
      otherwise have; and (d) any bankruptcy of Subtenant.

     

    9.  Until
      all
      Subtenant's obligations under the Sublease are fully performed, Guarantor.
      (a)
      shell have no right of subrogation against Subtenant by reason of any payment
      or
      acts of performance by Guarantor under this Guaranty or any other guaranty
      entered into by Guarantor; and (b) subordinates any liability or indebtedness
      of
      Subtenant now or hereafter held by Guarantor to the obligations of Subtenant
      under, arising out of or related to the Sublease or Subtenant's use of the
      premises demised thereby.

     

    10.  All
      rights, powers and remedies of Sublandlord hereunder and under any other
      agreement now or at any time hereafter in force between Sublandlord and
      Guarantor relating to the Sublease shall be cumulative and not alternative
      and
      such rights, powers and remedies shall be in addition to all rights, powers
      and
      remedies given to Sublandlord by law.

     

     

    
      
        
        

      

      
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    11.  Should
      any one or more provisions of this Guaranty be determined to be illegal or
      unenforceable, all other provisions shall nevertheless be
      effective.

     

    12.  This
      Guaranty shall be governed by and construed in accordance with the laws of
      the
      State of California.

     

    13.  The
      individual executing this Guaranty on behalf of Guarantor represents and
      warrants that he is duly authorized to execute and deliver this Guaranty on
      behalf of Guarantor in accordance with a duly adopted resolution of the Board
      of
      Directors of Guarantor or in accordance with the bylaws of Guarantor, and that
      this Guaranty is binding upon Guarantor in accordance with its
      terms.

     

    14.  Any
      notice, request, demand, instruction or other communication to be given to
      any
      party hereunder shall be in writing and shall be sent by registered
      or certified
      mail, return receipt requested, to Guarantor at the address provided under
      Guarantor's signature below, and if to Sublandlord, to the following
      addresses:

     

    Accupath
      Diagnostic Laboratories, Inc. 

    2601
      Campus Drive

    Irvine,
      California 92618

    Attention:
      CEO

     

    Notices
      shall be deemed to have been given forty-eight (48) hours after the deposit
      of
      the same in a United States mail post office box in a state to which the notice
      is addressed, or seventy-two (72) hours after deposit of same
      in
      any such post
      office box in a state other than the state to which the notice is addressed,
      postage prepaid and addressed as set forth above. A. notice shall not be deemed
      given unless and until it shall have been given to all address(es) to which
      notices must be sent. Any panty may change its address(es) for notices by a
      notice given in accordance with this Section.

     

    15.  No
      modification of this Guaranty shall be effective unless the same shall be in
      writing and signed by Guarantor and Sublandlord. No right of Sublandlord
      hereunder shall be deemed to have been waived by any act of Sublandlord or
      any
      failure to exercise such right or any delay in exercising such right. Any waiver
      by Sublandlord of any right of Sublandlord hereunder must be express and in
      writing to be effective. No right of Guarantor hereunder shall be deemed to
      have
      been waived by
      any
      act
      of Guarantor or any failure to exercise such right or any delay in exercising
      such rights. Any waiver of Guarantor of any right of Guarantor hereunder mist
      be
      express and in writing to be effective.

     

    16.  All
      of
      the terms, agreements and conditions of this Guaranty shall extend to and be
      binding upon Guarantor, its heirs, executors, administrators, successors and
      assigns, and shall inure to the benefit of and may be enforced by Sublandlord,
      its successors and assigns. Sublandlord may assign its rights under this
      Guaranty.

     

     

    
      
        
        

      

      
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    17.  If
      Sublandlord is
      required to enforce Guarantor's obligations under this Guaranty by any legal
      action or proceedings, or if a dispute arises in connection with the validity,
      enforceability, enforcement or construction of this Guaranty or any other matter
      relating to this Guaranty, the losing party shall pay all reasonable attorneys'
      fees incurred by the prevailing party in such dispute.

    

    18.  
      Guarantor hereby represents and warrants that: (a) Guarantor has received and
      reviewed the Sublease and is familiar with the terns thereof; (b) the execution
      of this Guaranty will
      not
      render Guarantor insolvent in any way; and (c) Sublandlord's entering into
      the
      Sublease materially benefits Guarantor and Guarantor is receiving fair
      consideration for this Guaranty.

     

    19.  
      Any
      amount required to be paid by Guarantor hereunder shall bear interest from
      the
      date due until the date paid at the lesser of: (a) thirteen percent (13%) per
      annum; or (b) the maximum rate permitted by law. All interest shall be
      compounded monthly and shall be payable to Sublandlord on demand.

    

    20.  Time
      is
      of the essence
      with
      respect
      to the performance of Guarantor's obligations hereunder.

     

    21.  This
      Guaranty contains the entire agreement of Guarantor and Sublandlord with respect
      to the subject matter hereof

     

    22.  
      Guarantor hereby consents to the personal jurisdiction and venue of any
      California state court and any United States court located in the State of
      California and the service of process authorized by any such court. Process
      may
      be served upon Guarantor at its address for notices specified
      herein.

     

    23.  All
      capitalized terms used in this Guaranty shall have the same meaning as those
      terms are used in the Sublease or the Lease.

     

    IN
      WITNESS WHEREOF, Guarantor has executed this Guaranty as of the day and year
      written above.

    

     

    "GUARANTOR"

    
      COMBIMATRIX
        CORPORATION, a

      Delaware
        corporation

      

      By:
        /s/ Scott Burrell

      Name:
        Scott Burrell

      Title:
        Vice President, Finance

    

     

    
      
        
        

      

      
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    Guarantor's
      Address for Notices:

    

    CombiMatrix
      Corporation

    6500
      Harbour Heights Parkway, Suite 301 

    Mukilteo,
      Washington 98275

    Attention:
      General Counsel

    

    

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