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Exhibit 10.23
FIRST AMENDMENT TO COMMERCIAL LEASE

THIS FIRST AMENDMENT TO COMMERCIAL LEASE (this “Amendment”) is entered into between TANNOS LAND HOLDINGS III, LLC, a Texas limited liability company (“Landlord”), and CASTLE BIOSCIENCE, INC., a Delaware corporation (“Tenant”), with reference to the following:

A.Landlord and Tenant entered into that certain Commercial Lease dated December 17, 2019 (the “Lease”) covering approximately 21,760 square feet of rentable area (the “Current Leased Premises”) on the fourth (4th) floor of the building located at 505 S Friendswood Drive. Friendswood, Texas 77546 (the “Building”).

B.Landlord and Tenant now desire to amend the Lease as set forth below. Unless otherwise expressly provided in this Amendment, capitalized terms used in this Amendment shall have the same meanings as in the Lease.

FOR GOOD AND VALUABLE CONSIDERATION, the receipt and sufficiency of which are acknowledged, the parties agree as follows:

1.First Expansion Space. Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, approximately 1,952 additional square feet of rentable area (the "First Expansion Space") located on the third (3rd) floor of the Building as shown on the attached Exhibit A, which is incorporated into this Amendment for all purposes. The term "Leased Premises" as used in the Lease means and includes approximately 23,712 square feet of rentable area, being the sum of the square feet of rentable area of the Current Leased Premises (21,760 square feet) and the First Expansion Space. The lease of the First Expansion Space is subject to all of the terms and conditions of the Lease currently in effect, except as modified in this Amendment.

2.Base Rent. Commencing on the First Expansion Space Commencement Date (as defined below) and continuing through the Expiration Date, Tenant shall, at the time and place and in the manner provided in the Lease, pay to Landlord as base monthly rent for the First Expansion Space the amounts set forth in the following rent schedule, plus any applicable tax thereon:

												
	FIRST EXPANSION SPACE

				
	

From
	

Through
	Annual Base Rent Rate Per Square Foot
	Base Monthly Rent

	FESCD
	Expiration Date
	$22.20
	$3,611.20

“FESCD” means the First Expansion Space Commencement Date.

3.Tenant’s Pro Rata Share of Taxes, Insurance and CAM. Commencing on the First Expansion Space Commencement Date, Tenant’s pro rata share of Taxes, Insurance and CAM shall be increased to take the First Expansion Space into consideration.

4.Condition of First Expansion Space. Landlord agrees to buildout the First Expansion Space pursuant to the terms of the Construction Agreement attached to the Lease, except that each occurrence of the term “Leased Premises shall be deleted and replaced with the term “First Expansion Space” and the text “after the date of this lease” shall be deleted and replaced with the text “after the date of this Amendment.” The term “FESCD” or First Expansion Space Commencement Date” means the day the leasehold improvements to be constructed by Landlord in the First Expansion Space pursuant to said Construction Agreement are Substantially Complete and notice thereof is delivered to Tenant.

5.Counterparts. This Amendment may be executed in multiple counterparts, and each counterpart when fully executed and delivered shall constitute an original instrument, and all such multiple counterparts shall constitute but one and the same instrument.

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6.Miscellaneous. This Amendment shall become effective only upon full execution and delivery of this Amendment by Landlord and Tenant. This Amendment contains the parties’ entire agreement regarding the subject matter covered by this Amendment, and supersedes all prior correspondence, negotiations, and agreements, if any,
whether oral or written, between the parties concerning such subject matter. There are no contemporaneous oral agreements, and there are no representations or warranties between the parties not contained in this Amendment. Except as modified by this Amendment, the terms and provisions of the Lease shall remain in full force and effect, and the Lease, as modified by this Amendment, shall be binding upon and shall inure to the benefit of the parties hereto, their successors and permitted assigns.

LANDLORD AND TENANT enter into this Amendment on November 13, 2020.

									
	LANDLORD:	TANNOS LAND HOLDINGS III, LLC, a Texas limited liability company

	
			
		By:	/s/ Louis Tannos
		Name:	Louis Tannos
		Title:	President
			
			
	TENANT	CASTLE BIOSCIENCES, INC., a Delaware corporation

	
			
		By:	/s/ Derek Maetzold
		Name:	Derek Maetzold
		Title:	President, and CEO

- 2 -Exhibit 4.1

 

SPECIMEN UNIT CERTIFICATE

 

NUMBER UNITS U-

 

	SEE REVERSE FOR 

CERTAIN 

DEFINITIONS	Corazon Capital V838 Monoceros 

Corp	 

 

CUSIP [ ] 

 

UNITS CONSISTING OF ONE CLASS A ORDINARY
SHARE AND ONE-THIRD OF ONE REDEEMABLE

WARRANT TO PURCHASE ONE CLASS A ORDINARY SHARE

 

THIS CERTIFIES ____________________ is the owner of __________ Units.

 

Each Unit (“Unit”) consists of one (1) Class A ordinary
share, par value $0.0001 per share (“Ordinary Shares”), of Corazon Capital V838 Monoceros Corp, a Cayman Islands exempted
company (the “Company”), and one-third (1/3) of one redeemable warrant (each whole warrant, a “Warrant”).
Each Warrant entitles the holder to purchase one (1) Ordinary Share for $11.50 per share (subject to adjustment). Each Warrant
will become exercisable on the later of (i) thirty (30) days after the Company’s completion of a merger, share exchange,
asset acquisition, share purchase, reorganization or other similar business combination with one or more businesses (each, a “Business
Combination”), and (ii) twelve (12) months from the closing of the Company’s initial public offering, and will expire
unless exercised before 5:00 p.m., New York City Time, on the date that is five (5) years after the date on which the Company completes
its initial Business Combination, or earlier upon redemption or liquidation (the “Expiration Date”). The Ordinary Shares
and Warrants comprising the Units represented by this certificate are not transferable separately prior to                    ,
2021, unless Citigroup Global Markets Inc. elects to allow earlier separate trading, subject to the Company’s filing with
the Securities and Exchange Commission of a Current Report on Form 8-K containing an audited balance sheet reflecting the Company’s
receipt of the gross proceeds of the initial public offering and issuing a press release announcing when separate trading will
begin. No fractional warrants will be issued upon separation of the Units and only whole warrants are exercisable. The terms of
the Warrants are governed by a Warrant Agreement, dated as of                    ,
2021, between the Company and Continental Stock Transfer & Trust Company, as Warrant Agent, and are subject to the terms and
provisions contained therein, all of which terms and provisions the holder of this certificate consents to by acceptance hereof.
Copies of the Warrant Agreement are on file at the office of the Warrant Agent at 1 State Street, 30th Floor, New York, New York
10004, and are available to any Warrant holder on written request and without cost.

 

Upon the consummation of the Business Combination,
the Units represented by this certificate will automatically separate into the Class A Ordinary Shares and Warrants comprising
such Units.

 

This certificate is not valid unless countersigned
by the Transfer Agent and Registrar of the Company.

 

This certificate shall be governed by and
construed in accordance with the internal laws of the State of New York.

 

Witness the facsimile signatures of its
duly authorized officers.

 

	By 	 	 	 
	 	Chief  Executive Officer	 	Chief Financial Officer

 

     

     

    

 

Corazon Capital V838 Monoceros Corp

 

The Company will furnish without charge
to each unitholder who so requests, a statement of the powers, designations, preferences and relative, participating, optional
or other special rights of each class of stock or series thereof of the Company and the qualifications, limitations, or restrictions
of such preferences and/or rights.

 

The following abbreviations, when used in
the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable
laws or regulations:

 

	TEN
    COM	—	as
    tenants in common	UNIF
    GIFT MIN ACT—		Custodian	
	TEN
    ENT	—	as
    tenants by the entireties	 	 	 	 
	JT
    TEN	—	as
    joint tenants with right of	 	(Cust)	 	(Minor)
			survivorship
    and not as tenants in common	 	under
        Uniform Gifts

        to
        Minors Act

         

	
	(State)

 

Additional abbreviations may also be used
though not in the above list.

 

For value received,
__________________ hereby sells, assigns and transfers unto _________________________

 

 

(PLEASE
INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE) 

 

	 
	(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)
	 
	 
	 
	 
	 

_________________________ Units represented by the within
Certificate, and hereby irrevocably constitutes and appoints _____________________ Attorney to transfer said Units on the books
of the within named Company with full power of substitution in the premises.

 

	Dated: _____________	 
	 	
        Shareholder

         

        Notice: The signature to this
        assignment must correspond with the name as written upon the face of the certificate in every particular, without alteration or
        enlargement or any change whatever.

         

 

	Signature(s) Guaranteed:

 

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	THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15 (OR ANY SUCCESSOR RULE)).	 

 

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In each case, as more fully described in the Company’s
final prospectus dated                      ,
2021, the holder(s) of this certificate shall be entitled to receive a pro-rata portion of certain funds held in the trust account
established in connection with the Company’s initial public offering only in the event that (i) the Company redeems the Ordinary
Shares sold in its initial public offering and liquidates because it does not consummate an initial business combination within
the period of time set forth in the Company’s amended and restated memorandum and articles of association, as the same may
be amended from time to time, (ii) the Company redeems the Ordinary Shares sold in its initial public offering in connection with
a shareholder vote to amend the Company’s amended and restated memorandum and articles of association (A) that would modify
the substance or timing of the Company’s obligation to provide holders of the Ordinary Shares the right to have their shares
redeemed in connection with the Company’s initial business combination or to redeem 100% of the Ordinary Shares if the Company
does not complete its initial business combination within the time period set forth therein or (B) with respect to any other provision
relating to the rights of holders of the Ordinary Shares, or (iii) if the holder(s) seek(s) to redeem for cash his, her or its
respective Ordinary Shares in connection with a tender offer (or proxy solicitation, solely in the event the Company seeks shareholder
approval of the proposed initial business combination) setting forth the details of a proposed initial business combination. In
no other circumstances shall the holder(s) have any right or interest of any kind in or to the trust account.

 

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