Document:

First Amendment to Lease Agreement

 EXHIBIT 10.5.1 
 THREE SISTERS RANCH 
 ENTERPRISES LLC 
 First AMENDMENT 
 Original Premises: 969 Industrial Road, Suite C, San Carlos,
California 
 New Premises: 981 Industrial Road, Suites D and F, San Carlos, California 
 THIS FIRST AMENDMENT TO LEASE (“Amendment”) is made and entered into effective as of December 10, 2001 (“Effective
Date”), by and between THREE SISTERS RANCH ENTERPRISES, LLC, a California limited liability company (“Landlord”), and NEUROGESX,
INC., a California corporation (“Tenant”) (Landlord and Tenant hereinafter may be referred to as the “Parties”), with respect to the following: 
 RECITALS 
 A. On or about
August 11, 2000 Landlord and Tenant entered into a Lease Agreement (“Lease”), attached hereto as Exhibit A (the Lease and this Amendment may hereinafter be sometimes referred to in the aggregate as the
“Lease”), respecting the premises at 969 Industrial Road, Suite C, San Carlos, California (the “Original Premises”). 
 B. Subsequent to the date on which Tenant and Landlord entered into the Lease, Tenant changed its name from Advanced Analgesics, Inc. to NeurogesX, Inc. 
 C. Tenant desires to move its operations from the Original Premises to a new location within the same Project at 981 Industrial Road, Suites D and F, San Carlos, California (the “Premises”). 
 D. The Parties hereby agree to amend the Lease to reflect the location change of Tenant. 
 E. The Parties hereby adopt the provisions of the Lease subject to this Amendment, which provides for certain modifications of the Lease in accordance
with and subject to all the terms and conditions set forth herein. 
  

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 AGREEMENT 
 THEREFORE, IT IS HEREBY MUTUALLY AGREED by and between the Parties hereto as follows: 
 1. BUILDING
DESCRIPTION. That approximately 23,200± square foot building known as 981 Industrial Road in San Carlos, California. The building is outlined in blue on Exhibit B. 
 2. PREMISES. That approximately 16,195± square feet of rentable area known as 981 Industrial Road, Suites D and F, San Carlos, California.
The demised Premises are outlined in pink on Exhibit B and the Site Plan is attached hereto as Exhibit C. 
 3.
PARKING DENSITY. Three (3) unreserved parking spaces per 1,000± sq.ft. of Rentable Area, up to a total of forty-nine (49) spaces. 
 4. ESTIMATED COMMENCEMENT DATE FOR NEW SPACE. The new space commencement date shall be upon substantial completion of Tenant Improvements, as provided in Section 12 hereto, to the Premises sufficient for
occupancy, partial or complete, but in no event later than March 1, 2002 (“New Space Commencement Date”). 
 5. LENGTH OF
NEW SPACE TERM. The term of the Lease shall be thirty-six (36) months from the New Space Commencement Date (“Term”). 
 6.
TERMINATION OF EXISTING SPACE. Tenant shall, on or prior to the New Space Commencement Date, but in no event later than March 1, 2002, vacate and cease to occupy, in whole or in part, and shall remove all of its personal property from,
the Original Premises. In the event Tenant fails to wholly vacate the Original Premises as provided above, Tenant’s obligations as to the Original Premises under the original Lease shall continue in full force and effect, including, but not
limited to, all obligations of Tenant for payment of Rent for the Original Premises. Landlord may, at Landlord’s option, consider Tenant’s failure to vacate the Original Premises as provided herein, as a default under the terms of the
original Lease. Upon the later of (i) the New Space Commencement Date or (ii) Tenant’s vacating of the Original Premises as provided herein or (iii) final inspection of the Original Premises by Landlord to its satisfaction,
and Tenant’s delivery to Landlord of all Rent and any and all other funds and obligations due upon commencement of the New Space, Tenant’s obligations under Section 12 of the Original Lease, only with respect to the Original
Premises, shall terminate. 
 7. BASE RENT. Base Rent provided below shall apply and be calculated based on the Term commencing on the
New Space Commencement Date pursuant to Paragraph 4 and 5 above, as follows: 
  

											
	Months	 	1-12:	 	$	1.50/sq.ft/mo. NNN	 	=	 	$	24,292.50/mo.
	Months	 	13-24:	 	$	1.55/sq.ft./mo. NNN	 	=	 	$	25,102.25/mo.
	Months	 	25-36:	 	$	1.60/sq.ft./mo. NNN	 	=	 	$	25,912.00/mo.

  

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 8. ESTIMATED FIRST YEAR BASIC OPERATING COST. The estimated first year basic operating cost for
the first twelve(12) months of the new space lease is as follows: 
  

									
	$0.26/sq.ft./mo.	 	=	 	$4,210.70/mo.	 	=	 	$50,528.40/yr.

 The operating cost for the balance of the Term shall be estimated and adjusted in accordance with
the terms of the Lease. 
 9. TENANT’S PROPORTIONATE SHARE. 
  

									
	Of Building:	 	69.8%	 	/	 	Of Project:	 	13.1%

 10. LAST MONTH’S RENT. Tenant shall deliver to Landlord upon execution of this
Amendment, two thousand four hundred seventy-seven dollars and 56/100 ($2,477.56) as Last Month’s Rent so that the total amount of Last Month’s Rent on hand is twenty-five thousand nine hundred twelve dollars and 00/100 ($25,912.00).

 11. SECURITY DEPOSIT. Tenant shall deliver to Landlord upon execution of this Amendment two thousand four hundred twelve dollars
and 00/100 ($2,412.00) Cash Security Deposit so that the total amount of Cash Security Deposit on hand is twenty-five thousand nine hundred twelve dollars and 00/100 ($25,912.00). 
 Notwithstanding the expiration of the Term, or any other provision of the Lease, in the event that Tenant has and continues to fulfill all of its duties
and obligations under this Lease, and that no amounts under the Letter of Credit have been drawn down and the Letter of Credit is and continues to be in effect, only then may the Letter of Credit applicable to year 1, 2 and 3 of the Term be reduced
so as to be in the total amount of $97,170.00, $50,204.50, and $-0-, respectively. Provided, however, that in the event there is an event of monetary or material non-monetary default by Tenant beyond applicable notice and cure periods at any time
during the Term, irrespective if any sums are actually drawn down under the Letter of Credit, Tenant shall immediately increase the sum of the Letter of Credit to an amount equal to no less than six (6) months Rent at the monthly rate of Rent
then applicable. Provided further, that in the event there is an event of default under the Lease, Tenant shall not be entitled to the reductions in amount under the Letter of Credit during the period remaining under the Lease. 
 Tenant shall deliver to Landlord upon execution of this Amendment a current effective Letter of Credit in the specified amount and with respect to the
new space. Should such Letter of Credit be cancelled, terminated or not otherwise renewed and timely delivered to Landlord or not issued for the benefit of Landlord or should an original of such Letter of Credit not, at all times, be kept on file
with Landlord’s property manager, any such event shall constitute a default under the Lease. 
 12. CONDITION OF PREMISES/TENANT
IMPROVEMENTS. 
 (a) Notwithstanding any provision of the Lease, except as provided below in this Section 12, there shall be no
tenant improvements provided by Landlord, and Tenant accepts the Premises “As-Is” without any representation or warranty on the part of Landlord, except Landlord 

  

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shall insure that the Premises and the building systems are in good working condition, including, but not limited to, HVAC, electrical and plumbing, and all
existing light fixtures shall be in good working order. The Tenant shall have the right to inspect the Premises to confirm that they are in good working condition prior to execution of this Amendment to Lease. 
 (b) Landlord shall reimburse to Tenant costs actually incurred and paid by Tenant at the rate of Five Dollars and 00/100 ($5.00) per rentable square foot
provided that the total of such reimbursement shall not exceed eighty thousand nine hundred seventy-five dollars and 00/100 ($80,975.00), for improvements to the new space Premises, including upgrading the existing restrooms, pursuant to
improvements previously approved by Landlord as to be set out in working drawings to be submitted to Landlord pursuant to Section (d) below (“Tenant Improvements”). 
 (c) Any tenant improvements undertaken by the Tenant shall, at a minimum, meet or exceed the then existing minimum building standards in effect at the
San Carlos Business Park and shall be accomplished in accordance with this Section, subject to the following modifications: 
 (i) Tenant
shall not commence construction of any Tenant Improvements until: 
 (1) all required governmental approvals and permits required for the
commencement of construction have been obtained, 
 (2) all requirements regarding insurance imposed by this Amendment and the Lease have
been satisfied, and 
 (3) Tenant has given Landlord at least ten (10) days’ prior written notice of Tenant’s intention to
commence construction, and has complied with Section (d) below. 
 (ii) In the event that Tenant shall make any alterations, additions,
or improvements to the Premises pursuant to the terms and provisions of this Section 12, Tenant agrees to carry fire and extended coverage insurance upon such alterations, additions, or improvements. In addition, Tenant shall carry or cause to
be carried all legally required liability coverage, including workers’ compensation insurance. It is expressly understood and agreed that Landlord shall not be required to insure any of such alterations, additions, or improvements under such
insurance as Landlord may carry upon the Premises, and that Landlord shall not be required under the provisions relating to reconstruction of the Premises, or under any other circumstances whatsoever, to repair, reconstruct, or reinstall any such
alterations, improvements, or additions. 
 (d) Landlord hereby approves Tenant’s use of CAS Architects as its architect and Rudolf and
Sletten as its general contractor. Tenant shall deliver, prior to commencement of any Tenant Improvements, a set of working drawings acceptable to Landlord. Landlord shall approve or disapprove of said improvements. Tenant anticipates that it shall
complete the Tenant Improvements in three phases. Tenant shall deliver to Landlord a set of acceptable working drawings and shall complete the improvements for each phase as Follows: Phase One in first quarter 2002, Phase Two in second quarter 2002,
and Phase Three in second and third quarter 2002. Tenant shall not be required to remove any approved Tenant Improvements upon termination of the Lease provided that 

  

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Tenant is not then in default under the Lease. Prior to vacating the Premises, any additional improvements constructed during the Term after the completion
of the initial Tenant Improvements not approved by Landlord or specialized improvements not approved by Landlord may be required to be removed, at the option of the Landlord, and the Premises restored, at the sole cost and expense of Tenant, subject
to ordinary wear and tear and Landlord’s review and approval. 
 13. RENEWAL OPTION CONDITIONS. Section 40 of the Lease is
amended and restated in its entirety as follows: 
 (a) Tenant shall have the option (“Extension Option”) to extend the Term for one
additional period of two (2) years (“Option Period”) by giving Landlord prior written notice of Tenant’s election to exercise this option not more than eighteen (18) months and no less than nine (9) months before the
expiration of the Term as the same may have been extended. The Extension Option shall be on all the same terms of this Amendment and the Lease provided that the Monthly Rent for such Option Period shall be determined in accordance with this Section.

 (b) The Extension Option is personal to the Tenant herein and any transfer of such Tenant’s interest in the Lease (other than a
permitted transfer), whether or not consented to by Landlord, shall cause such Extension Option to terminate and be of no further force or effect 
 (c) For purposes of this section, Monthly Rent shall be determined as follows: 
 (i) Parties shall have thirty (30) days from
the receipt by Landlord of Tenant’s notice electing to exercise the Extension Option, to agree on the Monthly Rent for the Option Period. If the Parties agree on the Monthly Rent for the Option Period, by such date, they shall immediately
execute an amendment to the Lease stating the Monthly Rent for the Option Period and memorializing the extension of the Term in accordance with the section hereof. 
 (ii) If the Parties are unable to agree upon the Monthly Rent for the Option Period in accordance with Subsection 13(c)(i) above, then within fourteen (14) days after the Parties fail to agree on the Monthly Rent
for the Option Period, each party, at its cost and by giving notice to the other party, shall appoint a real estate appraiser with at least five (5) years full time MAI appraisal experience in San Mateo County, to determine the Monthly Rent for
the Option Period, and shall deliver to said appraiser, as well as the other party, such party’s proposal for the Monthly Rent for the Option Period. If a party does not appoint an appraiser within said fourteen (14) day period and the
other party has given notice of the name of its appraiser, the single appraiser appointed shall be the sole appraiser and shall determine the Monthly Rent for the Option Period. If an appraiser is appointed by each of the Parties as provided in this
section, they shall meet promptly and attempt to set the Monthly Rent for the Option Period, by agreeing on which party’s proposal most closely reflects the Fair Market Rental Value of the Premises for the Option Period. If they are unable to
agree within thirty (30) days after the second appraiser has been appointed, the two appraisers shall within ten (10) days following the end of such thirty (30) day period choose a third appraiser or if the two appraisers cannot agree
upon a third appraiser within such ten (10) day period, either of the Parties to this Lease, by giving ten (10) days’ written notice to the other party, can apply to the then Presiding Judge of the San Mateo County Superior Court for
the appointment of a third appraiser who meets the qualifications stated in this section. Each of the Parties shall bear one-half 

  

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of the cost of appointing the third appraiser together with one-half of such appraiser’s fee. The third appraiser, however, shall be a person who has
not previously acted in any capacity for either party during the prior three years. Within thirty (30) days after the selection of the third appraiser, a majority of the appraisers shall determine which party’s proposal more closely
reflects the Fair Market Rental Value of the Premises for the Option Period. As used herein, “ Fair Market Rental Value” shall mean, the then prevailing annual rental rate per square foot of rentable area for office space in comparable
buildings in San Mateo County which has been built out for occupancy, comparable in area and location to the space for which such rental rate is being determined (to the extent that quoted rental rates vary with regard to location), being leased for
a duration comparable to the term for which such space is being leased and taking into consideration rental concessions and abatements, tenant improvement allowances, if any, being offered by Landlord, operating expenses and taxes, other adjustments
to basic rent and other comparable factors. 
 (iii) After the appraisers determine Which party’s proposal more closely reflects the
Fair Market Rental Value of the Premises for the Option Period, the appraisers shall immediately notify the Parties of their findings and the Parties shall immediately execute an amendment to this Lease stating the Monthly Rant for the Option Period
and memorializing the extension of the Term in accordance with Section 40 of the Lease. 
 (d) Tenant shall not have the right to
exercise the Extension Option or any option to renew the Lease that Landlord hereafter provides Tenant if (i) Tenant is in default of any terms of the Lease at the time that Tenant’s right to exercise the option is in effect,
(ii) Tenant has been in default of any terms of the Lease three (3) or more times during the Term of the Lease, or (iii) Tenant has assigned the Lease or sublet the Premises or any portion thereof with or without the consent of
Landlord. 
 14. MISCELLANEOUS. 
 All capitalized terms used, but not expressly defined, in this Amendment shall have the meanings assigned to them in the body of this Lease. 
 The provisions of this Amendment shall control if in conflict with any of the provisions of the body of the Lease or any exhibits or other attachments to the Lease. 
 Except as expressly provided in this Amendment, the Parties hereby reaffirm the Lease, and each provision thereof, in its entirety, and Tenant affirms
that neither Landlord nor, to the best of Tenant’s knowledge, Tenant is in breach or default of any of their respective obligations under the Lease. 
 This Amendment may be executed in counterparts. 
 The Parties have executed this Amendment as of the date
first set forth above. 
  

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	LANDLORD:	 	TENANT:
		
	 THREE SISTERS RANCH
	 	NEUROGESX, INC
	ENTERPRISES, LLC, a California	 	f/k/a Advanced Analgesics, Inc.
	Limited Liability Company	 	a California Corporation
				
	By:	 	 /s/ Martine E. Ruberry
	 	By:	 	 /s/ Howard Palefsky

		 	Martin E. Ruberry	 		 	Howard Palefsky
	Its:	 	President/CEO	 	Title:	 	President/CEO
					
		 		 		 	By:	 	 /s/ Darrell W. Baggs

	 	 		 		 	Name:	 	Darrell W. Baggs
		 		 		 	Title:	 	CFO/Secretary

  

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 EXHIBIT A 
 [LEASE AGREEMENT] 
  

 Page 8 of 8Second Amendment to Lease Agreement

 EXHIBIT 10.5.2 
 THREE SISTERS RANCH 
 ENTERPRISES LLC 
 SECOND AMENDMENT 
 THIS SECOND AMENDMENT TO LEASE
(“Amendment”) is made and entered into effective as of March 3, 2005 (“Effective Date”), by and between THREE SISTERS RANCH ENTERPRISES, LLC, a
California limited liability company (“Landlord”), and NEUROGESX, INC., a California corporation (“Tenant”): 
 This
Second Lease Addendum is attached to and forms a part of the Lease identified below together with any amendments, modifications and exhibits. This Second Lease Addendum constitutes additional covenants and agreements which are intended to prevail in
the event of any conflict between the covenants and agreements contained in this Second Lease Addendum and those contained in the Lease itself and/or the Lease Addenda. Except for the additions, changes and removals listed herein, all other terms
and conditions of the Lease will remain in full force and effect throughout the term of the Lease. 
 RECITALS 
 A. On or about August 11, 2000, Landlord and Tenant entered into a lease (“Lease”), for the certain premises owned by
Landlord and thereafter executed a first amendment on December 1, 2001 moving from the original premises of 969 Industrial Road, Suite C, San Carlos, CA to current premises. Tenant current leases 16,195 square feet of 981 Industrial Road,
Suites D and F, San Carlos, California 94070 (together, the “Premises”), that are all part of a building complex more commonly known as the San Carlos Business Park. 
 B. Tenant has notified Landlord that Tenant intends to extend their lease that expires February 28, 2005 noted in recital A above.

 TERMS AND CONDITIONS 
 THEREFORE, IT IS HEREBY MUTUALLY AGREED by and between the Parties hereto as follows: 
  

	 	1.	During the remaining Term of the Lease, for so long as Tenant is not in material default under any of the provisions of the Lease shall be amended to read as follows:

  

	 	2.	The term of this Lease Extension shall commence March 1, 2005 and expire December 31, 2006. 

  

	 	3.	Tenant would like to modify the amount of space presently Tenant currently leases by reducing the total rentable square footage to 10,956 square feet. The breakdown of this new
space is as shown in Exhibit A. 

	 	4.	Base Rent shall be $12,730.50 per month for the extended lease term. Reimbursable C.A.M. charges shall be $3,269.50 per month for the extended lease term. Total monthly rent for the
extended term shall be $16,000.00 per month. 

  

	 	5.	Landlord will provide or repair items detailed in e-mail to Marty Ruberry dated February 14, 2005 (shown in Exhibit B ). 

  

	 	6.	Landlord will reduce last month’s rent and security deposit to $32,000.00 from $51,824.00. A refund check in the amount of $19,824.00 will be prepared upon execution of the
lease amendment. 

 The provisions of this Amendment shall control if in conflict with any of the provisions of the body of the
Lease or any exhibits or other attachments to the Lease. 
 Except as expressly provided in this Second Amendment, the Parties hereby
reaffirm the Lease and each provision thereof, in its entirety, and Tenant affirms that neither Landlord nor, to the best of Tenant’s knowledge, Tenant is in breach or default of any of their respective obligations under the Lease. 

This Amendment may be executed in counterparts. 
 IN WITNESS HEREOF, the Parties have executed this Second Lease Amendment as of the date first set forth above. 
  

									
	LANDLORD:	 		 	TENANT:
	THREE SISTERS RANCH	 		 	NEUROGESX, INC.
	 ENTERPRISES, LLC, a California
	 		 	a California Corporation
	 Limited Liability Company
	 		 	
					
	 By:
	 	 /s/ Martin E. Ruberry
	 		 	By:	 	 /s/ Stephen Ghiglieri

		 	Martin E. Ruberry	 		 		 	Stephen Ghiglieri
	Its:	 	President	 		 		 	CFO
					
	 Date:
	 	2/28/05	 		 	Date:	 	2/28/05
		 		 		 	By:	 	  

		 		 		 	Date:	 	  

  

 -2- 

 Exhibit “A” 
 [Blueprint of Premises] 

 Exhibit “B” 
 [E-mail to Martin Ruberry]

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