Document:

Exhibit 10.11

COLLATERAL ASSIGNMENT OF

TRADEMARKS, TRADEMARK

APPLICATIONS,

PATENTS AND PATENT

APPLICATIONS

THIS

COLLATERAL ASSIGNMENT OF TRADEMARKS, TRADEMARK APPLICATIONS, PATENTS AND PATENT

APPLICATIONS is made as of December 7, 2001 by and among HAUSER, INC., a

Delaware corporation, HAUSER TECHNICAL SERVICES, INC., a Delaware Corporation,

BOTANICALS INTERNATIONAL EXTRACTS, INC., a Delaware corporation, ZETAPHARM,

INC., a New York corporation, (each, an “Assignor” and collectively, the

“Assignors”), and Wells Fargo Bank, National Association (the “Assignee”).

W I T N E S S E T H:

WHEREAS,

Assignors are the owners of certain trademarks, trademark applications, patents

and patent applications listed in Exhibit A attached to this document; and

WHEREAS,

Assignors and Assignee have entered into that certain Amended and Restated

Credit Agreement dated as of December 7, 2001 (as from time to time amended,

modified or supplemented, the “Credit Agreement”), pursuant to which, upon the

satisfaction by the Assignors of the terms and conditions contained therein,

Assignee will make loans to Assignors; and

WHEREAS,

pursuant to the Credit Agreement, Assignors have agreed to grant Assignee a

security interest in all of their right, title and interest in and to the

trademarks, trademark applications, patents and patent applications described

in Exhibit A, and in and to the goodwill symbolized by such trademarks (the

“Goodwill”), as collateral security for the Obligations as defined in the

Credit Agreement; and

WHEREAS,

except as noted on Exhibit A attached to this document, Assignors are the

owners of the entire right, title and interest in the trademarks, trademark

applications, patents and patent applications being assigned hereby.

NOW,

THEREFORE, in consideration of the foregoing and other good and valuable

consideration, Assignors hereby:

1.             Assign, pledge and grant to

Assignee, as security for the Obligations, a security interest in and to the

trademarks, trademark applications, patents and patent applications listed in Exhibit

A attached to this document, and to the Goodwill, and a security interest in

and to all trademarks, trademark applications, Goodwill, patents and patent

applications acquired by Assignors after the date hereof.

 

 

 

2.             Authorize and request the Commissioner

of Patents and Trademarks of the United States of America and the empowered

officials of all other governments to note in the record the existence of the

security interest granted hereunder with respect to each of the trademarks,

trademark applications, patents and patent applications listed in Exhibit A

attached to this document, and to the Goodwill, and to all trademarks,

trademark applications, Goodwill, patents and patent applications acquired by

Assignors after the date hereof.

3.             Acknowledge that notices and other

communications shall be in writing and given as provided in Section 9.01 of the

Credit Agreement. Communications and notices to any Assignor shall be given to

it at its address set forth in Exhibit B attached to this document.

4.             Agree upon the request of Assignee

and at the expense of Assignors to take any reasonable actions and execute any

documents necessary to effectuate this assignment and the security interest

created in the trademarks, trademark applications, patents and patent

applications listed in Exhibit A to this document.

[Balance

of Page Intentionally Left Blank]

 

 

IN

WITNESS WHEREOF, Assignors have caused this Assignment to be signed by their

respective authorized officers as of the day and year first above written.

	

   

  	

  ASSIGNEE:

  
	

   

  	

   

  
	

   

  	

  WELLS

  FARGO BANK, NATIONAL

  
	

   

  	

  ASSOCIATION

  
	

   

  	

   

  
	

  By:

  	

  /s/  Art Brokx

  
	

   

  	

  Name:  Art Brokx

  
	

   

  	

  Title:  VP

  
	

   

  	

   

  
	

   

  	

  ASSIGNORS:

  
	

   

  	

   

  
	

   

  	

  HAUSER,

  INC.

  
	

   

  	

   

  
	

  By:

  	

  /s/  Kenneth C. Cleveland

  
	

   

  	

  Name:  Kenneth C. Cleveland

  
	

   

  	

  Title:  Chief Executive Officer

  
	

   

  	

   

  
	

   

  	

  HAUSER

  TECHNICAL SERVICES, INC.

  
	

   

  	

   

  
	

  By:

  	

  /s/  Thomas W. Hanlon

  
	

   

  	

  Name:  Thomas W. Hanlon

  
	

   

  	

  Title:  Secretary and Treasurer

  
	

   

  	

   

  
	

   

  	

  BOTANICALS

  INTERNATIONAL EXTRACTS, INC.

  
	

   

  	

   

  
	

  By:

  	

  /s/  Kenneth C. Cleveland

  
	

   

  	

  Name:  Kenneth C. Cleveland

  
	

   

  	

  Title:  Chief Executive Officer

  
	

   

  	

   

  

 

	

   

  	

  ZETAPHARM,

  INC.

  
	

   

  	

   

  
	

  By:

  	

  /s/  Thomas W. Hanlon

  
	

   

  	

  Name:  Thomas W. Hanlon

  
	

   

  	

  Title:  Secretary and Treasurer

  
	

   

  	

   

  

 

EXHIBIT

A TO COLLATERAL ASSIGNMENT

ISSUED U.S. PATENTS

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  OXIDATION

  PRODUCTS OF CEPHALOMANNINE

  	

   

  	

  5,336,684

  	

   

  	

  8/9/1994

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ELECTROPLATING

  OF SUPERCONDUCTOR ELEMENTS

  	

   

  	

  5,470,820

  	

   

  	

  11/28/1995

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ELECTROPLATING

  OF SUPERCONDUCTOR ELEMENTS

  	

   

  	

  5,244,875

  	

   

  	

  9/14/1993

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  OXIDATION OF

  GLYCOSIDE SUBSTITUTED TAXANES TO TAXOL OR TAXOL PRECURSORS AND NEW TAXANE

  COMPOUNDS FORMED AS INTERMEDIATES

  	

   

  	

  5,412,116

  	

   

  	

  5/2/1995

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  OXIDATION OF

  CEPHALOMANNINE WITH OZONE IN THE PRESENCE OF TAXOL

  	

   

  	

  5,334.732

  	

   

  	

  8/2/1994

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PROCESS FOR

  SEPARATING CEPHALOMANNINE FROM TAXOL USING OZONE AND WATER-SOLUBLE HYDRAZINES

  OR HYDRAZIDES

  	

   

  	

  5,364,947

  	

   

  	

  11/15/1994

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  GIRARD

  DERIVATIVES OF TAXANES (AS AMENDED)

  	

   

  	

  5,792,877

  	

   

  	

  8/11/1998

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PREPARATION OF

  10-DEACETYLBACATIN III AND 7-PROTECTED-10-DEACETYLBACCATIN III DERIVATIVES

  FROM 10-DEACETYLETAXOL A, 10-DEACETYL TAXOL B, AND 10-DEACETYL TAXOL

  	

   

  	

  5,449, 790

  	

   

  	

  9/12/1995

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  CEPHALOMANNINE

  EXPOXIDE, ITS ANALOGUES A METHOD FOR PREPARING THE SAME

  	

   

  	

  5,892,063

  	

   

  	

  4/6/1999

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  7 —HEXANOL YL T

  AXOL AND METHOD FOR PREPARING THE SAME

  	

   

  	

  6,136,988

  	

   

  	

  10/24/2000

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  SELECTIVE

  PROCESS FOR THE DEACETYLATION OF TAXOL AND TAXANES

  	

   

  	

  5,629,433

  	

   

  	

  5/13/1997

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  5,679,807

  	

   

  	

  10/21/1997

  	

   

  

 

 

 

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  5,808,113

  	

   

  	

  9/15/1998

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ARTEMISININ

  DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY

  	

   

  	

  5,677,468

  	

   

  	

  10/14/1997

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ARTEMISININ

  DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY

  	

   

  	

  5,856,351

  	

   

  	

  1/5/1999

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  TRIOXANE DIMER

  COMPOUNDS HAVING ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  6,004,997

  	

   

  	

  12/21/1999

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  STORAGE STABLE,

  CITRUS-FLAVORED COMPOSITIONS COMPRISING PLANT EXTRACTS

  	

   

  	

  6,306,450

  	

   

  	

  10/23/2001

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LiKE TRIOXANE COMPOUNDSHAVING ANTIMALARIAL,

  ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  6,156, 790

  	

   

  	

  12/5/2000

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LiKE TRIOXANE COMPOUNDSHAVING ANTIMALARIAL,

  ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  6,160,004

  	

   

  	

  12/12/2000

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ARTEMISININ

  ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE,AND ANTITUMOR ACTIVITIES AND

  CHEMOSElECTIVE METHODS OF MAKING THE SAME

  	

   

  	

  6,297,272

  	

   

  	

  1 0/2/2001

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  HIGH MOLECULAR

  WEIGHT PRIMARY ALIPHATIC ALCOHOLS OBTAINED FROM BEESWAX AND PHARMACEUTICAL

  USE THEREOF

  	

   

  	

  6,225,354

  	

   

  	

  5/1/2001

  	

   

  

 

 

A - 2

ISSUED EUROPEAN PATENTS

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  ARTEMISININ

  DIMERS WITH ANTICANCER ACTIVITY

  	

   

  	

  0882037

  	

   

  	

  9/12/2001

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  ARTEMISININ

  DIMERS WITH ANTICANCER ACTIVITY

  	

   

  	

  69615220.7-0

  	

   

  	

  9/12/2001

  	

   

  

 

A - 3

PENDING INTERNATIONAL PATENT APPLICATIONS

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  METHOD FOR

  ISOLATION OF CAFFEINE-FREE CATECHINS FROM GREEN TEA

  	

   

  	

  PCT/USOO/00282

  	

   

  	

  2/1/2000

  	

   

  
	

  COMPOSITIONS

  COMPRISING NATURAL AGENTS FOR TREATMENT OF CANCER

  	

   

  	

  PCT/US01/12096

  	

   

  	

  4/13/2001

  	

   

  
	

  COMPOSITIONS

  COMPRISING ICARISIDE I AND ANHYDROICARITIN AND METHODS FOR MAKING THE SAME

  	

   

  	

  PCT/US01/22700

  	

   

  	

  7/19/2001

  	

   

  
	

  EFFICIENT METHOD

  FOR PRODUCING COMPOSITIONS ENRICHED IN ANTHOCYANINS

  	

   

  	

  PCT/US01/27107

  	

   

  	

  8/30/2001

  	

   

  

 

A - 4

PENDING JAPANESE PATENT APPLICATIONS

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  OXIDATION

  PRODUCTS OF CEPHALOMANNINE

  	

   

  	

  524451/94

  	

   

  	

  4/25/1994

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  OXIDATION OF

  GLYCOSIDE SUBSTITUTED TAXANES TO TAXOLORTAXOLPRECURSORS AND NEW TAXANE

  COMPOUNDS FORMED AS INTERMEDIATES

  	

   

  	

  512190/94

  	

   

  	

  11/2/1993

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  CEPHALOMANNINE

  EXPOXIDE, ITS ANALOGUES METHOD FOR PREPARING THE SAME

  	

   

  	

  8-527756

  	

   

  	

  3/8/1996

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  7-HEXANOL YL

  TAXOL AND METHODS FOR PREPARING THE SAME

  	

   

  	

  2000-543447

  	

   

  	

  4/9/1999

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  8-523705

  	

   

  	

  1/30/1996

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  TRIOXANE DIMERS

  HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  10-525676

  	

   

  	

  12/1/1997

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  STORAGE STABLE,

  CITRUS-FLAVORED COMPOSITIONS COMPRISING PLANT EXTRACTS

  	

   

  	

  11-504963

  	

   

  	

  6/23/1998

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LiKE TRIOXANE COMPOUNDSHA VING ANTIMALARIAL,

  ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  PCT/US98/27717

  	

   

  	

  12/30/1998

  	

   

  

 

A - 5

PENDING OTHER FOREIGN PATENT APPLICATIONS

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  OXIDATION

  PRODUCTS OF CEPHALOMANNINE

  	

   

  	

  2,161,138

  	

   

  	

  4/25/1994

  	

   

  
	

  OXIDATION OF

  GLYCOSIDE SUBSTITUTED TAXANES TO TAXOL OR TAXOL PRECURSORS AND NEW TAXANE

  COMPOUNDS FORMED AS INTERMEDIATES

  	

   

  	

  2,148,943

  	

   

  	

  11/2/1993

  	

   

  
	

  CEPHALOMANNINE

  EXPOXIDE, ITS ANALOGUES METHOD FOR PREPARING THE SAME

  	

   

  	

  2,214,993

  	

   

  	

  3/8/1996

  	

   

  
	

  7-HEXANOL YL

  TAXOL AND METHODS FOR PREPARING THE SAME

  	

   

  	

  34888/99

  	

   

  	

  4/9/1999

  	

   

  
	

  7-HEXANOL YL

  TAXOL AND METHODS FOR PREPARING THE SAME

  	

   

  	

  2,327,791

  	

   

  	

  4/9/1999

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  2,211,799

  	

   

  	

  1/30/1996

  	

   

  
	

  ARTEMISININ

  DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY

  	

   

  	

  2,234,731

  	

   

  	

  6/27/1996

  	

   

  
	

  TRIOXANE DIMERS

  HAVING ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  2,273,374

  	

   

  	

  12/1/1997

  	

   

  
	

  STORAGE STABLE,

  CITRUS-FLAVORED COMPOSITIONS COMPRISING PLANT EXTRACTS

  	

   

  	

  2,294,458

  	

   

  	

  6/23/1998

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDSHAVING ANTIMALARIAL,

  ANTI PROLIFERATIVE AND ANTITUMOUR ACTIVITIES

  	

   

  	

  20184/99

  	

   

  	

  12/30/1998

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDSHAVING ANTIMALARIAL,

  ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  2,317,112

  	

   

  	

  12/30/1998

  	

   

  
	

  ARTEMISININ

  ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE,AND ANTITUMOR ACTIVITIES AND

  CHEMOSELECTIVE METHODS OF MAKING THE SAME

  	

   

  	

  27239/00

  	

   

  	

  1/11/2000

  	

   

  

 

A - 6

 

	

  ARTEMISININ

  ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE,AND ANTITUMOR ACTIVITIES AND

  CHEMOSELECTIVE METHODS OF MAKING THE SAME

  	

   

  	

  XXXXXX

  	

   

  	

  1/11/2000

  	

   

  

 

A - 7

ISSUED OTHER FOREIGN PATENTS

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  OXIDATION

  PRODUCTS OF CEPHALOMANNINE

  	

   

  	

  685119

  	

   

  	

  4/30/1998

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  694,627

  	

   

  	

  11/5/1998

  	

   

  
	

  ARTEMISININ

  DIMER COMPOUNDS HAVING ANTICANCER ACTIVITY

  	

   

  	

  725724

  	

   

  	

  10/19/2000

  	

   

  
	

  TRIOXANE DIMERS

  HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  730722

  	

   

  	

  6/28/2001

  	

   

  

 

A - 8

PENDING U.S. PATENT APPLICATIONS

 

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  PROCESS OF

  CONVERTING OXO-10-DAXT INTO 10-DEACETYL BACCATIN III (CIP)

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PROCESS OF

  CONVERTING BACCATIN III INTO 10-DEACETYL BACCATIN III

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  7-HEXANOYL TAXOL

  AND METHOD FOR PREPARING THE SAME

  	

   

  	

  09/688,753

  	

   

  	

  10/16/2000

  	

   

  
	

  TRIOXANE DIMERS

  HAVING ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  09/717,815

  	

   

  	

  11/21/2000

  	

   

  
	

  STORAGE STABLE,

  CITRUS-FLAVORED COMPOSITIONS COMPRISING PLANT EXTRACTS

  	

   

  	

  not yet assigned

  	

   

  	

  10/19/2001

  	

   

  
	

  HIGH PURITY

  BETA-CAROTENE AND PROCESS FOR OBTAINING SAME

  	

   

  	

  08/864,103

  	

   

  	

  5/28/1997

  	

   

  
	

  ARTEMISININ

  ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE,AND ANTITUMOR ACTIVITIES AND

  CHEMOSELECTIVE METHODS OF MAKING THE SAME

  	

   

  	

  09/887,922

  	

   

  	

  6/22/2001

  	

   

  
	

  COMPOSITIONS

  COMPRISING NATURAL AGENTS FOR TREATMENT OF CANCER

  	

   

  	

  09/550,436

  	

   

  	

  4/17/2000

  	

   

  
	

  COMPOSITIONS

  COMPRISING ICARISIDE I AND ANHYDROICARITIN ANDMETHODS FOR MAKING THE SAME

  	

   

  	

  09/638,367

  	

   

  	

  8/15/2000

  	

   

  
	

  EFFICIENT METHOD

  FOR PRODUCING COMPOSITIONS ENRICHED IN ANTHOCYANINS

  	

   

  	

  09/943, 158

  	

   

  	

  8/30/2001

  	

   

  
	

  HIGH MOLECULAR

  WEIGHT PRIMARY ALIPHATIC ALCOHOLS OBTAINED FROM NATURAL PRODUCTS AND USES

  THEREOF

  	

   

  	

  09/845,043

  	

   

  	

  4/27/2001

  	

   

  
	

  HIGH MOLECULAR

  WEIGHT PRIMARY ALIPHATIC ALCOHOLS OBTAINED FROM NATURAL PRODUCTS AND USES

  THEREOF

  	

   

  	

  09/949,285

  	

   

  	

  9/7/2001

  	

   

  

 

A - 9

PENDING EUROPEAN PATENT

APPLICATIONS

	

  Title

  	

   

  	

  Patent No.

  	

   

  	

  Grant Date

  	

   

  
	

  OXIDATION OF

  GLYCOSIDE SUBSTITUTED TAXANES TO TAXOL ORTAXOL PRECURSORS AND NEW TAXANE

  COMPOUNDS FORMED AS INTERMEDIATES

  	

   

  	

  94900515.1

  	

   

  	

  11/2/1993

  	

   

  
	

  7 —HEXANOL YL T

  AXOL AND METHODS FOR PREPARING THE SAME

  	

   

  	

  99916599.6

  	

   

  	

  4/9/1999

  	

   

  
	

  PREPARATION OF

  TAXOL AND DOCETAXEL THROUGH PRIMARY AMINES

  	

   

  	

  96907021.8

  	

   

  	

  1/30/1996

  	

   

  
	

  TRIOXANE DIMERS

  HAVING ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  97949655.1

  	

   

  	

  12/1/1997

  	

   

  
	

  STORAGE STABLE,

  CITRUS-FLAVORED COMPOSITIONS COMPRISING PLANT EXTRACTS

  	

   

  	

  98929112.5

  	

   

  	

  6/23/1998

  	

   

  
	

  C-10

  CARBON-SUBSTITUTED ARTEMISININ-LIKE TRIOXANE COMPOUNDSHA VING ANTIMALARIAL,

  ANTI PROLIFERATIVE AND ANTITUMOR ACTIVITIES

  	

   

  	

  98964977.7

  	

   

  	

  12/30/1998

  	

   

  
	

  PROCESS FOR

  REMOVING IMPURITIES FROM NATURAL PRODUCT EXTRACTS

  	

   

  	

  99956616.9-

  	

   

  	

  10/20/1999

  	

   

  
	

  ARTEMISININ

  ANALOGS HAVING ANTIMALARIAL, ANTIPROLIFERATIVE,AND ANTITUMOR ACTIVITIES AND

  CHEMOSElECTIVE METHODS OF MAKING THE SAME

  	

   

  	

  00905584.9

  	

   

  	

  1/11/2000

  	

   

  

 

A - 10

REGISTERED TRADEMARKS

	

  European

  Union

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  Mark

  	

   

  	

  Number

  	

   

  	

  Registration

  Date

  	

   

  
	

  NATURAL RATIO

  (Classes: 05)

  	

   

  	

  001417674

  	

   

  	

  02/14/01

  	

   

  

 

PENDING TRADEMARKS

	

  United

  States

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  Mark

  	

   

  	

  Number

  	

   

  	

  Filing Date

  	

   

  
	

  APISOL (Classes:

  05)

  	

   

  	

  76-193748

  	

   

  	

  01/12/01

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  BIOENHANCE

  (Classes: 05)

  	

   

  	

  76-193420

  	

   

  	

  01/12/01

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  INVIGORA

  (Classes: 05)

  	

   

  	

  76-089302

  	

   

  	

  07/14/00

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  NATURAL RATIO

  (Classes: 05)

  	

   

  	

  75-726748

  	

   

  	

  06/11/99

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  NATURAL RATIO

  (Classes: 42)

  	

   

  	

  75-726749

  	

   

  	

  06/11/99

  	

   

  
	

   

  	

   

  	

   

  	

   

  	

   

  	

   

  
	

  PREVENTIA

  (Classes: 05)

  	

   

  	

  76-089329

  	

   

  	

  07/14/00

  	

   

  

 

NYC1 #431294 v1

 

A - 11EXHIBIT 10.18

 

ACKNOWLEDGEMENT AND CONSENT

TO AMENDED AND RESTATED CREDIT

AGREEMENT

 

This ACKNOWLEDGEMENT AND

CONSENT TO AMENDED AND RESTATED CREDIT AGREEMENT (this “Acknowledgement  and

Consent” ) is dated as of December 7, 2001 and entered into

by the undersigned, and is made with reference to that certain Amended and

Restated Credit Agreement dated as of the date hereof (the “Restated

Credit Agreement” ), by and among Hauser, Inc., Hauser

Technical Services, Inc., Botanicals International Extracts, Inc., Zetapharm,

Inc., Wilcox Natural Products, Inc. (collectively, the “Borrowers”), and Wells Fargo

Bank, National Association (the “Lender”), which amends and restates that

certain Credit Agreement dated as of June 11, 1999 (as amended, supplemented or

otherwise modified prior to the date hereof, the “Original

Credit Agreement”) by and among the Borrowers and the

Lender.  Capitalized terms used herein

without definition shall have the same meanings herein as set forth in the

Restated Credit Agreement.

 

Each of the undersigned hereby acknowledges that it is

a party to the Restated Credit Agreement and that, notwithstanding amendment,

such agreement remains in full force and effect.  Each of the Borrowers hereby acknowledges that it has reviewed

the terms and provisions of the Restated Credit Agreement and consents to the

amendment and restatement of the Original Credit Agreement effected pursuant to

the Restated Credit Agreement.  Each of

the Borrowers hereby confirms that each of the Security Documents to which it

is a party or otherwise bound and all Collateral encumbered thereby will

continue to guaranty or secure, as the case may be, to the fullest extent

possible the payment and performance of all Obligations including, without

limitation, the payment and performance of all such Obligations of the

Borrowers now or hereafter existing under or in respect of the Restated Credit

Agreement and the Notes defined therein. 

Without limiting the generality of the foregoing, each of the Borrowers

hereby acknowledges and confirms the understanding and intent of such party

that, upon the Effective Date, the definition of “Obligations” contained in the

Restated Credit Agreement includes the obligations of the Borrowers under the

Term Note and the Revolving Credit Note which amend and restate the Notes (as

such term is defined in the Original Credit Agreement).

 

Each of the Borrowers acknowledges and agrees that any

of the Security Documents to which it is a party or otherwise bound shall

continue in full force and effect and that all of its obligations thereunder

(which obligations on the date hereof remain absolute and unconditional and are

not subject to any defense, set-off or counterclaim) shall be valid and

enforceable and shall not be impaired or limited by the execution or

effectiveness of this Acknowledgment and Consent.  Each of the Borrowers represents and warrants that all

representations and warranties contained in the Restated Credit Agreement and

the Security Documents to which it is a party or otherwise bound are true and

correct in all material respects on and as of the Effective Date to the same

extent as though made on and as of that date, except to the extent such

representations and warranties specifically relate to an earlier date, in which

case they were true and correct in all material respects on and as of such

earlier date.  In addition, and without

limiting the foregoing, each of the Borrowers represents and warrants that

except as stated in Schedule 1 annexed hereto, there has been no change in any

of the information set forth in, or annexed to, the Perfection Certificate

dated as of June 11, 1999 executed by the Chief Financial Officer of the

Company and delivered to the Lender pursuant to the Original Credit Agreement

and the Security Documents.

 

THIS ACKNOWLEDGEMENT AND CONSENT AND THE RIGHTS AND

OBLIGATIONS OF THE UNDERSIGNED SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND

ENFORCED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CALIFORNIA

WITHOUT REGARD TO CONFLICTS OF LAWS PRINCIPLES.

 

This Acknowledgement and Consent may be executed in

counterparts (and by different parties hereto on different counterparts), each

of which shall constitute an original, but all of which when taken together

shall constitute a single contract.

 

 

 

IN WITNESS WHEREOF, the

undersigned has caused this Acknowledgement and Consent to be duly executed and

delivered by their respective officers thereunto duly authorized as of the date

first written above.

 

	

  THE BORROWERS:

  	

   

  	

   

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  HAUSER,

  INC.

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  By:

  	

   /s/  Kenneth C. Cleveland

  	

   

  
	

   

  	

   

  	

  Name: 

  Kenneth C. Cleveland

  
	

   

  	

   

  	

  Title:  Chief

  Executive Officer

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  HAUSER

  TECHNICAL SERVICES,

  INC.

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  By:

  	

   /s/  Thomas W. Hanlon

  	

   

  
	

   

  	

   

  	

  Name:  Thomas

  W. Hanlon

  
	

   

  	

   

  	

  Title: 

  Secretary and Treasurer

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  BOTANICALS

  INTERNATIONAL

  EXTRACTS, INC.

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  By:

  	

   /s/  Kenneth C. Cleveland

  	

   

  
	

   

  	

   

  	

  Name: 

  Kenneth C. Cleveland

  
	

   

  	

   

  	

  Title:  Chief

  Executive Officer

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  ZETAPHARM,

  INC.

  
	

   

  	

   

  	

   

  
	

   

  	

   

  	

  By:

  	

   /s/  Thomas W. Hanlon

  	

   

  
	

   

  	

   

  	

  Name:  Thomas

  W. Hanlon

  
	

   

  	

   

  	

  Title: 

  Secretary and Treasurer

  
						

 

S-1

 

Schedule 1.0

 

S-2

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