Document:

Exhibit 10.13

 

CANCER PREVENTION PHARMACEUTICALS,
INC.

 

AMENDMENT TO INVESTORS’ RIGHTS
AGREEMENT

 

This Amendment to Investors’
Rights Agreement (“Amendment”) is made as of September 27, 2012 by and between Cancer Prevention Pharmaceuticals, Inc.,
a Delaware corporation (the “Company”) and the undersigned Investors. Capitalized terms used but not otherwise defined
herein shall have the meanings assigned to such terms in that certain Investor Rights Agreement dated as of September 17, 2012
between the Company and the Investors (the “Agreement”).

 

WHEREAS, together, the
undersigned Investors and the Company are authorized and desire to amend the Agreement in the manner herein provided.

 

NOW THEREFORE, in consideration
of the mutual covenants, promises and agreements of the Company and the undersigned Investors and other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

 

		1.	Amendment of Agreement. The Company and the undersigned Investors hereby amend the Agreement
in the manner set forth herein. Except as specifically provided herein, the terms of the Agreement shall remain in full force and
effect.

 

		2.	Recitals. Recitals B, C, and D are hereby amended to read as follows:

 

		B.	The Company proposes to sell, or has sold,
shares (“Financing”) of its Series A-2 Convertible Preferred Stock (“Series A-2 Preferred”)
to the purchasers identified on Series A-2 Preferred Stock Purchase Agreement (the “Purchase Agreement”).

 

		C.	The Investors are, or will be, either (i) former Note Holders of the Notes which have been converted
pursuant to the Conversion or (ii) purchasers of Series A-2 Preferred listed on the Purchase Agreement.

 

		D.	As a condition to the Financing and the
Conversion, the Parties have agreed to enter into this Agreement.

 

		3.	Definitions – Section 1.1.

 

		A.	The following definitions are added to Section 1.1 of the Agreement:

  

“Initial Closing”
shall mean the date of the initial sale of shares of the Company’s Series A Preferred Stock under the Purchase Agreement.

 

“Purchase Agreement”
shall have the meaning set forth in the Recitals.

 

    Page 1 of 2

     

    

  

“Series A
Preferred Stock” shall mean the Company’s Series A-1 Convertible Preferred Stock and Series A-2 Convertible
Preferred Stock.

 

		B.	The following definitions are amended to read as follows:

 

“Conversion
Stock” shall mean shares of Common Stock issued upon conversion of the Series A Preferred Stock.

 

“Right of First Refusal
and Co-Sale Agreement” shall mean the agreement of that name of even date herewith by and between the Company, the
holders of Series A Preferred Stock and certain holders of Common Stock.

 

The parties are signing this Amendment to
Investors’ Rights Agreement as of the date stated in the introductory clause.

 

	Cancer Prevention Pharmaceuticals, Inc.	 
	 	 
	By:	/s/ Jeffrey Jacob	 
	 	Jeffrey Jacob, CEO	 

 

	Stockholder	 	Signature	 	Series
    A-1

    Preferred

    Shares Held
	 	 	 	 	 
	Frank and Linda Meyskens	 	/s/
    Frank Meyskens	 	61,045
	 	 	Frank Meyskens	 	 
	 	 	 	 	 
	Eugene and Sandra Gerner	 	/s/
    Eugene Gerner	 	60,963
	 	 	Eugene Gerner	 	 
	 	 	 	 	 
	Jeffrey E. Jacob	 	/s/
    Jeffrey Jacob	 	122,009
	 	 	Jeffrey Jacob	 	 
	 	 	 	 	 
	GDB Investments, LLP	 	/s/
    Daniel Donovan	 	672,643
	 	 	Daniel Donovan	 	 
	 	 	 	 	 
	Translational Accelerator, LLC	 	/s/
    Eric Tooker	 	2,021,853
	 	 	Eric Tooker	 	 

 

    Page 2 of 2Exhibit 10.14

 

CANCER PREVENTION PHARMACEUTICALS,
INC.

 

VOTING AGREEMENT

 

September 17, 2012

 

    	 	1	 

     

    

 

CANCER PREVENTION PHARMACEUTICALS,
INC.

 

VOTING AGREEMENT

 

This Voting Agreement
(this “Agreement”) is made as of September 17, 2012 by and among Cancer Prevention Pharmaceuticals,
Inc., a Delaware corporation (the “Company”), the persons and entities listed on Exhibit A (each
an “Investor,” and collectively the “Investors”), and the persons listed on
Exhibit B (each a “Founder,” and collectively the “Founders”). The Founders
and the Investors are referred to herein collectively as the “Voting Parties.”

 

RECITALS

 

A.            Each Founder
currently owns the number of shares of the Company’s Common Stock indicated beside such Founder’s name in Exhibit B.

 

B.             Certain holders
(“Note Holders”) of the Company’s Convertible Promissory Notes (“Notes”)
are desirous of converting, or have converted, the principal amount of and accrued interest on the Notes into the Company’s
Series A-1 Convertible Preferred Stock (“Series A Preferred”) in accordance with the terms of the Series A-1 Preferred
Stock Purchase Agreement of even date herewith (the “Purchase Agreement”).

 

C.            The Investors
are former Note Holders whose Notes have been converted into Series APreferred in accordance with the terms thereof.

 

D.            The Purchase
Agreement contemplates that the Voting Parties will enter into this Agreement.

 

AGREEMENTS

 

The parties therefore
agree as follows:

 

Section 1

VOTING AGREEMENT

 

1.1          Shares Held
Subject to this Agreement. The Voting Parties agree to hold all shares of voting capital stock of the Company registered in
their respective names or beneficially owned by them as of the date of this Agreement and any and all other shares of voting capital
stock of the Company (“Shares”) legally or beneficially held or acquired by each of the Voting Parties
after the date of this Agreement, and to vote those shares in accordance with, the provisions of this Agreement.

 

1.2           Drag-Along
Rights. If Investors holding at least eighty percent (80%) of the shares of Series A Preferred held by all Investors, approve
a Change of Control Transaction (as defined below), each of the Founders and Investors agrees: (i) to raise no objection thereto
and to vote all shares held by such Founder or Investor over which that holder exercises voting power in favor of such Change
of Control Transaction, (ii) to sell or exchange all shares of Common Stock then held by such Founder or Investor pursuant to
the terms and conditions of such Change of Control Transaction, and (iii) to refrain from exercising any dissenters’ rights
or rights of appraisal under applicable law at any time with respect to such Change of Control Transaction; subject to the following
conditions:

 

(a)       no
Founder or Investor shall be required to make any representation, covenant or warranty in connection with the Change of Control
Transaction, other than as to such Founder’s or Investor’s ownership and authority to sell, free of liens, claims and
encumbrances, the shares of Common Stock proposed to be sold by such Founder or Investor;

 

    	 	2	 

     

    

 

(b)       no
Voting Party will be required to make any out-of-pocket expenditure (other than modest expenditures for postage, copies, telecommunications
and the like) before the consummation of the Change of Control Transaction, or if such expenditures are incurred, is entitled to
reimbursement thereof by the Company;

 

(c)       the
consideration payable for each share in each class or series as a result of such Change of Control Transaction is the same (except
for cash payments in lieu of fractional shares) as for each other share in such class or series;

 

(d)       each
class and series of capital stock of the Company will be entitled to receive the same form of consideration (and be subject to
the same indemnity and escrow provisions) as a result of such Change of Control Transaction, or have the choices with respect thereto;
and

 

(e)       upon
the consummation of the Change of Control Transaction, each Investor shall receive the same proportion of the aggregate consideration
from the Change of Control Transaction as the Investor would have received if that aggregate consideration had been distributed
by the Company in accordance with the Company’s Amended and Restated Certificate of Incorporation (“Certificate”),
if such Change of Control Transaction were a Liquidation Event within the meaning of Article IV Section 3 thereof.

 

SECTION 2

COVENANTS OF THE COMPANY

 

2.1          Covenants
of the Company. The Company agrees to use its best efforts to ensure that the rights given to the Voting Parties hereunder
are effective and that the Voting Parties enjoy the benefits thereof. The Company will not, by any voluntary action, avoid or seek
to avoid the observance or performance of any of the terms to be performed hereunder by the Company, but will at all times in good
faith assist in the carrying out of all of the provisions of this Agreement and in the taking of all such actions as may be necessary,
appropriate or reasonably requested by the holders of a majority of the outstanding voting securities held by the Voting Parties
assuming exercise and conversion of all outstanding securities in order to protect the rights of the parties hereunder against
impairment and to assist the Voting Parties in the exercise of their rights and the performance of their obligations hereunder.

 

SECTION 3

Termination

 

3.1          Termination.
This Agreement shall terminate upon the earlier of (i) the conversion of all outstanding shares of Series A Preferred into
Common Stock or, if done in connection with a Change of Control Transaction, upon the consummation thereof; or (ii) the agreement
of a majority-in-interest of the Founders and a majority-in-interest of the Investors, voting and acting separately. “Change
of Control Transaction” means either (a) the Company being acquired by another entity through any transaction
or series of related transactions to which the Company is party (including, without limitation, any stock acquisition, reorganization,
merger or consolidation but excluding any sale of stock for capital raising purposes) that results in the voting securities of
the Company outstanding immediately prior thereto failing to represent immediately after such transaction or series of transactions
(either by remaining outstanding or by being converted into voting securities of the surviving entity or the entity that controls
such surviving entity) a majority of the total voting power represented by the outstanding voting securities of the Company, such
surviving entity or the entity that controls such surviving entity; or (b) a sale, lease or other conveyance of all or substantially
all of the assets of the Company, but in all cases, excluding an Equity Financing.

 

    	 	3	 

     

    

 

SECTION 3

ADDITIONAL SHARES

 

3.1          Additional
Shares. If after the date of this Agreement any shares or other securities (other than pursuant to a Change of Control Transaction)
are issued on, or in exchange for, any of the Shares because of any stock dividend, stock split, consolidation of shares, reclassification
or consolidation involving the Company, such shares or securities shall be deemed to be Shares under this Agreement.

 

SECTION 4

RESTRICTIVE LEGEND

 

4.1          Restrictive
Legend. Each certificate representing any of the Shares subject to this Agreement shall be marked by the Company with a legend
reading substantially as follows:

 

THE SHARES EVIDENCED
HEREBY ARE SUBJECT TO A VOTING AGREEMENT (A COPY OF WHICH MAY BE OBTAINED FROM THE ISSUER), AND BY ACCEPTING ANY INTEREST IN SUCH
SHARES THE PERSON HOLDING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE PROVISIONS OF SAID VOTING
AGREEMENT.

 

The Company agrees
that, during the term of this Agreement, it will not remove, and will not permit to be removed (upon registration of transfer,
reissuance of otherwise), the legend from any such certificate and will place or cause to be placed the legend on any new certificate
issued to represent Shares theretofore represented by a certificate carrying the legend.

 

SECTION 5

Miscellaneous

 

5.1          Certain Definitions.
Shares “held” by a Voting Party shall mean any Shares directly or indirectly owned (of record or beneficially)
by such Voting Party or as to which such Voting Party has voting power. “Vote” shall include any exercise
of voting rights whether at an annual or special meeting or by written consent or in any other manner permitted by applicable law.
A “majority-in-interest” of either the Founders or the Investors shall mean the holders of a majority
of the Common Stock (determined on an as-converted basis) then held by such Group.

 

5.2          Notices.
All notices and other communications required or permitted hereunder shall be in writing and shall be mailed by registered or certified
mail, postage prepaid, sent by facsimile or electronic mail (if to a Voting Party) or otherwise delivered by hand, messenger or
courier service addressed:

 

(a)        If
to a Voting Party, to the Voting Party’s address, facsimile number or electronic mail address as shown in the exhibits to
this Agreement or in the Company’s records, as may be updated in accordance with the provisions hereof, or, until any such
Voting Party so furnishes an address, facsimile number or electronic mail address to the Company, then to the address, facsimile
number or electronic mail address of the last holder of the relevant Shares for which the Company has contact information in its
records. 

 

    	 	4	 

     

    

 

(b)        If to the Company,
to the attention of the Chief Executive Officer or Chief Financial Officer of the Company at 1760 E. River Road, Suite 250, Tucson,
AZ 85718, or at such other current address as the Company shall have furnished to the Voting Parties.

 

Each such notice or
other communication shall, for all purposes of this Agreement, be treated as effective or having been given (i) if delivered
by hand, messenger or courier service, when delivered (or if sent via a nationally-recognized overnight courier service, freight
prepaid, specifying next-business-day delivery, one business day after deposit with the courier), or (ii) if sent via mail,
at the earlier of its receipt or five days after the same has been deposited in a regularly-maintained receptacle for the deposit
of the United States mail, addressed and mailed as aforesaid, or (iii) if sent via facsimile, upon confirmation of facsimile
transfer or, if sent via electronic mail, upon confirmation of delivery when directed to the relevant electronic mail address,
if sent during normal business hours of the recipient, or if not sent during normal business hours of the recipient, then on the
recipient’s next business day. For any conflict between the Company’s books and records and this Agreement or any notice
delivered hereunder, the Company’s books and records will control absent fraud or error.

 

5.3          Successors
and Assigns. The provisions of this Agreement shall inure to the benefit of, and be binding upon, the successors, assigns,
heirs, executors and administrators of the parties. The Company shall not permit the transfer of any Shares on its books or issue
a new certificate representing any Shares unless and until the person to whom such security is to be transferred shall have executed
a written agreement pursuant to which such person becomes a party to this Agreement and agrees to be bound by all the provisions
hereof as if such person was a Voting Party hereunder.

 

5.4          Governing
Law. This Agreement shall be governed in all respects by the internal laws of Arizona as applied to agreements entered into
among Arizona residents to be performed entirely within Arizona, without regard to principles of conflicts of law.

 

5.5          Titles and
Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing
or interpreting this Agreement. All references in this Agreement to sections, paragraphs and exhibits shall, unless otherwise provided,
refer to sections and paragraphs hereof and exhibits attached hereto.

 

5.6           Further Assurances.
Each party agrees to execute and deliver, by the proper exercise of its corporate, limited liability company, partnership or other
powers, all such other and additional instruments and documents and do all such other acts and things as may be necessary to more
fully effectuate this Agreement.

 

5.7          Additional
Parties. Following the effective date of this Agreement, the Company agrees to cause each employee of the Company who comes
to hold at least 5% of the shares, or options to purchase 5% of the shares, of the Company’s Common Stock (determining such
percentage by summing (i) the outstanding Common Stock, (ii) any outstanding options or warrant to purchase Common Stock,
and (iii) any authorized but unissued option or warrants to purchase Common Stock) to become a party to this Agreement and be deemed
a “Founder” hereunder and no amendment of this Agreement pursuant to this paragraph or any consent or
approval of any other Investor shall be required as a condition to such Founder’s execution and delivery of an additional
counterpart signature page to this Agreement.

 

    	 	5	 

     

    

 

5.8           Entire Agreement.
This Agreement and the exhibits hereto constitute the full and entire understanding and agreement between the parties regarding
the subjects hereof. No party shall be liable or bound to any other party regarding the subjects hereof or thereof by any warranties,
representations or covenants except as specifically set forth herein.

 

5.9           No Grant
of Proxy. This Agreement does not grant any proxy and should not be interpreted as doing so. Nevertheless, should the provisions
of this Agreement be construed to constitute the granting of proxies, such proxies shall be deemed coupled with an interest and
are irrevocable for the term of this Agreement.

 

5.10        Not a Voting
Trust. This Agreement is not a voting trust governed by Section 218 of the Delaware General Corporation Law and should
not be interpreted as such.

 

5.11        Specific
Performance. It is agreed and understood that monetary damages would not adequately compensate an injured party for the breach
of this Agreement by any party, that this Agreement shall be specifically enforceable, and that any breach or threatened breach
of this Agreement shall be the proper subject of a temporary or permanent injunction or restraining order. Further, each party
waives any claim or defense that there is an adequate remedy at law for such breach or threatened breach.

 

5.12        Amendment.
Except as expressly provided herein, neither this Agreement nor any term hereof may be amended, waived, discharged or terminated
other than by a written instrument referencing this Agreement and signed by (i) the Company, (ii) Founders (who are then
employed by the Company) holding a majority of the Common Stock (determined on an as-converted basis) held by all Founders and
(iii) Investors holding a majority of the Common Stock (determined on an as-converted basis) held by all Investors; provided,
however, that if any amendment, waiver, discharge or termination operates in a manner that treats any Investor different from
other Investors the consent of such Investor shall also be required for such amendment, waiver, discharge or termination. Any such
amendment, waiver, discharge or termination effected in accordance with this paragraph shall be binding upon each Voting Party
that has entered into this voting agreement. Each Voting Party acknowledges that by the operation of this paragraph, the holders
of a majority of the Common Stock (determined on an as-converted basis) held by all Founders (who are then employed by the Company)
and the holders of a majority of the Common Stock (determined on an as-converted basis) held by all Investors will have the right
and power to diminish or eliminate all rights of such Voting Party under this Agreement.

 

5.13        No Waiver.
The failure or delay by a party to enforce any provision of this Agreement will not in any way be construed as a waiver of any
such provision or prevent that party from thereafter enforcing any other provision of this Agreement. The rights granted both parties
hereunder are cumulative and will not constitute a waiver of either party’s right to assert any other legal remedy available
to it.

 

5.14        Jurisdiction
and Venue. For any disputes arising out of or related to this Agreement, the parties consent to the exclusive jurisdiction
of, and venue in, the state courts in Pima County, Arizona (or for exclusive federal jurisdiction, the courts of the District of
Arizona).

 

5.15        Attorney’s
Fees. If any suit or action is instituted to enforce any provision in this Agreement, the prevailing party in such dispute
shall be entitled to recover from the losing party such reasonable fees and expenses of attorneys and accountants, which shall
include, without limitation, all fees, costs and expenses of appeals.

 

    	 	6	 

     

    

 

5.16        Severability.
If any provision of this Agreement becomes or is declared by a court of competent jurisdiction to be illegal, unenforceable or
void, portions of such provision, or such provision in its entirety, if necessary, shall be severed from this Agreement, and such
court will replace such illegal, void or unenforceable provision of this Agreement with a valid and enforceable provision that
will achieve, if possible, the same economic, business and other purposes of the illegal, void or unenforceable provision. The
balance of this Agreement shall be enforceable in accordance with its terms.

 

5.17        Counterparts.
This Agreement may be executed in one or more counterparts, each of which will be deemed an original, but all of which together
will constitute one and the same agreement. Facsimile copies of signed signature pages will be deemed binding originals.

 

5.18        Aggregation
of Stock. All securities held or acquired by affiliated entities (including affiliated venture capital funds) or persons of
an Investor, or an Investor’s partners, members, officers and employees or those of its affiliated entities or persons, shall
be aggregated together for purposes of determining the availability of any rights under this Agreement or making any computation
provided for hereunder

 

The parties are signing
this Voting Agreement as of the date stated in the introductory clause.

 

	 	 	CANCER PREVENTION PHARMACEUTICALS, INC.
	 	 	a Delaware corporation
	 	 	 
	 	 	 
	 	 	By: Jeffrey Jacob
	 	 	Its:  CEO
	 	 	 
	 	 	INVESTOR
	 	 	 
	 	 	 

 

(Signature Page to
Voting Agreement)

 

    	 	7	 

     

    

 

Exhibit A

 

INVESTORS

 

	Name	 	Number of Series
 A Preferred 
 Shares Held	 
	ATROX Partners, LLC	 	 	5,191	 
	CPP Investors, LLC	 	 	35,453	 
	Desert Angels CPP Investors, LLC	 	 	24,626	 
	Desert Sidecar I, LLC	 	 	6,494	 
	Eugene and Sandra Gerner	 	 	5,188	 
	Frank and Linda Meyskens	 	 	5,195	 
	GDB Investment, LLP	 	 	57,242	 
	Jeffrey E. Jacob	 	 	10,383	 
	Joshua Schein 2009 Spearfish Trust	 	 	24,655	 
	Keating Securities, LLC	 	 	47,561	 
	Meyer & Doreen Luskin Family Trust	 	 	32,572	 
	Miramar Ventures, LLC	 	 	10,376	 
	RBC Capital Markets cust FBO Susan Dubow IRA	 	 	4,924	 
	Robert Selby, M.D.	 	 	13,629	 
	Translational Accelerator, LLC	 	 	172,059	 
	Valencia 235, LLC	 	 	18,348	 
	Total	 	 	473,896	 

 

    	 	8	 

     

    

 

Exhibit B

 

FOUNDERS

 

	Name	 	Number of

 Common Shares

 Held	 
	Meyskens Pharmaceutical Investors, LLC	 	 	353,982	 
	Gerner Pharmaceutical Investors, LLC	 	 	353,982	 
	Tierney Family Trust	 	 	176,991	 
	Jeffrey Jacob	 	 	115,045	 
	Total	 	 	1,000,000	 

 

    	 	9

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00252-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00252-of-00352.parquet"}]]