Document:

<PAGE>

[Confidential Treatment Requested. Confidential Portions of this Agreement
have been redacted and have been separately filed with the Commission.]

                                                                  EXHIBIT 10.2

                                                                  EXECUTION COPY

                   FIRST AMENDMENT OF COLLABORATIVE RESEARCH
                     AND DEVELOPMENT AND LICENSE AGREEMENT

     This First Amendment of Collaborative Research and Development and License
Agreement is made and effective as of September 25, 2000, by and among Becton,
Dickinson and Company, a New Jersey corporation through its BD Biosciences
Division, having a place of business at 7 Loveton Circle, Sparks, Maryland 21152
(hereinafter "Becton"), Nanogen, Inc., a Delaware corporation having its
principal office and place of business at 10398 Pacific Center Court, San Diego,
California 92121 (hereinafter "Nanogen") and The Nanogen/Becton Dickinson
Partnership, a Delaware general partnership, having a place of business at 10398
Pacific Center Court, San Diego, California 92121 (hereinafter "the
Partnership").

     WHEREAS, Becton, Nanogen and the Partnership are parties to a certain
Collaborative Research and Development and License Agreement (hereinafter
"CRDA") effective 1 October 1997; and

     WHEREAS, the parties desire to amend certain provisions of the CRDA.

     NOW, THEREFORE, for good and valuable consideration, the parties hereby
agree as follows:

     1.   Paragraph 1.6 is hereby amended by adding a period after the
          parenthesis after the word "parasites" and by deleting the remainder
          of that sentence and the following sentence in that paragraph.

     2.   Paragraph 1.8 is hereby amended to read in its entirety as follows:

          "Master Agreement" shall mean that certain Master Agreement dated as
          of October 1, 1997, as amended as of September 25, 2000, between
          Becton and Nanogen.

     3.   Paragraph 1.13 is hereby amended to read in its entirety as follows:

          "Partnership Agreement" shall mean that certain General Partnership
          Agreement dated asof October 1, 1997, as amended as of September 25,
          2000, between the Partners.

     4.   The licenses respectively granted by Becton pursuant to Paragraphs
          6.1(a)(i) and (ii) and by Nanogen pursuant to Paragraphs 6.1(b)(i) and
          (ii) are hereby deemed terminated and of no further force and effect.

     5.   New Paragraph 6.1(d) is hereby added as follows:

          (d) The Partnership hereby: (i) grants to Becton a worldwide,
          royalty-free, exclusive license in and to Program Inventions listed in
          Exhibit A hereto

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                                                                               2

          (hereinafter "Product Commercialization Rights") to make, have made,
          use, offer to sell, sell and import Products in the Field, for the
          sole purpose of hereby granting to Nanogen, a worldwide,
          royalty-bearing, exclusive sublicense, with a limited right to grant
          further sublicenses, in and to Product Commercialization Rights to
          make, have made, use, offer to sell, sell and import Products in the
          Field by means of a certain Partnership Product Commercialization
          License Agreement to be executed concurrently herewith; (ii) assigns
          and transfers to Nanogen all right, title and interest in and to
          Program Inventions listed in Exhibit B hereto by means of a certain
          Partnership to Nanogen Assignment Agreement to be executed
          concurrently herewith; (iii) assigns and transfers to Becton all
          right, title and interest in and to Program Inventions listed in
          Exhibit C hereto by means of a certain Partnership to Becton
          Assignment Agreement to be executed concurrently herewith; and (iv)
          assigns and transfers to Nanogen and Becton jointly all right, title
          and interest in and to Program Inventions listed in Exhibit D hereto
          by means of a certain Partnership to Nanogen and Becton Assignment
          Agreement to be executed concurrently herewith.

     6.   Paragraph 6.6 is hereby deemed deleted in its entirety.

     7.   Paragraph 7.1 is hereby amended by adding the words "and Paragraph
          6.1(d)" after the words "Paragraph 6.1(c)" in the first sentence.

     8.   In Paragraph 12, the Notice address for Becton is hereby amended to
          read as follows (the address for copies remaining unchanged):

          BD Biosciences
          7 Loveton Circle
          Sparks, Maryland 21152
          Attn: Vice President, Licensing and Patents
          and the facsimile number for Nanogen is hereby amended to read "858-
          410-4949" instead of "619 546-7717".

     Except with respect to the foregoing  amendments,  all other  provisions of
the CRDA remain unmodified and in full force and effect.

                        [SIGNATURES APPEAR ON NEXT PAGE]

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                                                                               3

     IN WITNESS WHEREOF, the parties have executed this First Amendment of
Collaborative Research and Development and License Agreement through duly
authorized representatives on the dates set forth below, effective as of the
date first written above.

NANOGEN, INC.                               BECTON, DICKINSON AND COMPANY
                                            THROUGH ITS BD BIOSCIENCES DIVISION

By:  /s/ HOWARD C. BIRNDORF              By:   /s/ VINCENT A. FORLENZA
    ------------------------------          ----------------------------------
         Authorized Signature                     Authorized Signature

                                            VINCENT A. FORLENZA
      HOWARD C. BIRNDORF                    SENIOR VICE PRESIDENT
      CHAIRMAN AND CEO                      TECHNOLOGY, STRATEGY & DEVELOPMENT
    ------------------------------          ----------------------------------
         Name and Title                           Name and Title

Date:      9/27/00                     Date:  September 28, 2000
    ------------------------------          ----------------------------------

THE NANOGEN/BECTON DICKINSON PARTNERSHIP,
 A DELAWARE GENERAL PARTNERSHIP

NANOGEN VENTURE LLC                         BECTON DICKINSON VENTURE LLC
GENERAL PARTNER                             GENERAL PARTNER

By:  /s/ HOWARD C. BIRNDORF               By:    /s/ VINCENT A. FORLENZA
    ------------------------------            ----------------------------------
         Authorized Signature                      Authorized Signature

                                              VINCENT A. FORLENZA
       HOWARD C. BIRNDORF                     SENIOR VICE PRESIDENT
       CHAIRMAND & CEO                        TECHNOLOGY, STRATEGY & DEVELOPMENT
    ------------------------------            ----------------------------------
         Name and Title                            Name and Title

Date:    9-27-00                         Date:  September 28, 2000
    ------------------------------            ----------------------------------

<PAGE>
                                                                               4

                                   APPENDIX A
                        PRODUCT COMMERCIALIZATION RIGHTS

1.   *************************************************************************
     *************************************************************************
     *************************************************************************

2.   *************************************************************************
     *************************************************************************
     *************************************************************************

3.   *************************************************************************
     *************************************************************************
     *************************************************************************

4.   *************************************************************************
     *************************************************************************
     *************************************************************************
     *************************************************************************

5.   *************************************************************************
     *************************************************************************
     *************************************************************************

6.   U. S. Patent No. 6,066,461, entitled "Amplification and Detection of
     Campylobacter jejuni and Campylobacter coli"

7.   *************************************************************************
     *************************************************************************

8.   U. S. Patent No. 6,060,252, entitled "Amplification and Detection of
     Shigella spp. and Enteroinvasive Strains of Escherichia coli"

9.   *************************************************************************
     *************************************************************************

-------------------
*** Confidential material redacted and separately filed with the Commission.

<PAGE>
                                                                               5

10.  U. S. Patent No. 6,043,041, entitled "Amplification and Detection of
     Shiga-like Toxin II Producing Organisms"

11.  *************************************************************************
     *************************************************************************

-------------------
*** Confidential material redacted and separately filed with the Commission.

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                                                                               6

                                   APPENDIX B
                     PROGRAM INVENTIONS ASSIGNED TO NANOGEN

1.   ***********************************************************************
     ***********************************************************************

2.   ***********************************************************************
     ***********************************************************************

3.   ***********************************************************************
     ***********************************************************************

-------------------
*** Confidential material redacted and separately filed with the Commission.

<PAGE>
                                                                               7

                                   APPENDIX C
                      PROGRAM INVENTIONS ASSIGNED TO BECTON

1.   ***********************************************************************
     ***********************************************************************

2.   ***********************************************************************
     ***********************************************************************

-------------------
*** Confidential material redacted and separately filed with the Commission.

<PAGE>
                                                                               8

                                   Appendix D
            PROGRAM INVENTIONS ASSIGNED TO NANOGEN AND BECTON JOINTLY

1.   ***********************************************************************
     ***********************************************************************

2.   ***********************************************************************
     ***********************************************************************

3.   ***********************************************************************
     ***********************************************************************
     ***********************************************************************

4.   ***********************************************************************

-------------------
*** Confidential material redacted and separately filed with the Commission.<PAGE>

[Confidential Treatment Requested. Confidential Portions of this Agreement
have been redacted and separately filed with the Commission.]

                                                                    EXHIBIT 10.3

                                                                  EXECUTION COPY

                FIRST AMENDMENT OF GENERAL PARTNERSHIP AGREEMENT

     This First Amendment of General Partnership Agreement is made and effective
as of September 25, 2000, by and between Becton Dickinson Venture LLC, a
Delaware limited liability company (the "Becton Partner"), and NanoVenture LLC,
a Delaware limited liability company (the "Nanogen Partner"). The Becton Partner
and the Nanogen Partner are hereinafter collectively referred to as the
"Partners".

     WHEREAS, the Partners formed a Delaware general partnership known as The
Nanogen/Becton Dickinson Partnership, as of October 1, 1997, pursuant to a
certain General Partnership Agreement dated as of October 1, 1997 (the
"Partnership Agreement"); and

     WHEREAS, the Partners desire to amend certain provisions of the Partnership
Agreement.

     NOW THEREFORE, for good and valuable consideration, the Partners hereby
agree to amend the Partnership Agreement as follows:

     1. The definitions of "Master Agreement" and "Research Agreement" contained
in Section 1.1 are each hereby deemed amended to refer to the fact that each has
been amended as of September 25, 2000.

     2. In Section 17, the Notice address for the Becton Partner is hereby
amended to read as follows (the address for required copies remaining
unchanged):

         If to the Becton Partner, to:

                           Becton Dickinson Venture LLC
                           c/o BD Biosciences
                           7 Loveton Circle
                           Sparks, Maryland  21152
                           Attn:   Vice President, Licensing and Patents

     3. Nothing contained in Section 12(b) shall operate or be construed to
prevent the Partners or their respective Affiliates from engaging in any of the
activities enumerated therein in competition with the Partnership Business, as
same is defined in the Master Agreement, dated as of October 1, 1997 by and
between the Partners and/or their Affiliates for all periods prior to amendment
of such Master Agreement on September 25, 2000; provided, however, that no
rights, express or implied, are hereby conferred on either Partner or its
respective Affiliates in any intellectual property rights of any of the
Partnership, either Partner or its respective Affiliates, other than those
provided in (a) the First Amendment of Collaborative Research and Development
and License Agreement, (b) the License Agreement and (c) the First Amendment to
License Agreement, all dated as of September 25, 2000 by and between the
Partners and/or the Affiliates.

<PAGE>

     4. A new Section 8.1(a)(vi) is hereby added as follows:

                           (vi)     In addition to the contributions set forth
                                    above in Sections 8.1(a)(i) through (v), the
                                    Becton Partner hereby agrees to make a *****
                                    contribution to the Partnership in the
                                    amount of Three Hundred Thousand Dollars
                                    ($300,000).

     5. Section 8.4 is amended by adding the following sentence to the end of
     the Section:

                           The contributions made by the Becton Partner pursuant
                           to Section 8.1(a)(vi) shall be used to ************
                           ***************************************************
                           ***************************************************
                           ********* pursuant to the Collaborative Research and
                           Development and License Agreement.

     IN WITNESS WHEREOF, the Partners have executed this First Amendment of
General Partnership Agreement through duly authorized representatives on the
dates set forth below, effective as of the date first written above.

BECTON DICKINSON VENTURE LLC

BY:  BECTON, DICKINSON AND COMPANY,
        SOLE MEMBER

        By:    /s/ VINCENT FORLENZA
            ---------------------------

Date: September 28, 2000
      ------------------------------

NANOVENTURE LLC

By:     /s/ HOWARD C. BIRNDORF
    --------------------------------

Date:    9/27/2000
      -------------------------------

------------------
*** Confidential material redacted and separately filed with the Commission.

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