Document:

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                                                                    Exhibit 10.2

           DATED                 22ND AUGUST                    2005
           ---------------------------------------------------------

                             THE KENT COUNTY COUNCIL

                                       and

                                 GENZYME LIMITED

           ---------------------------------------------------------

                                DEED OF VARIATION

                                       of

                          LEASE dated 19th January 2001
                        re: 50 Gibson Drive, Kings Hill,
                               West Malling, Kent

           ---------------------------------------------------------

                               Ref: LS/A/88154/17

                        wp ref: BEACH/DOCUMENTS/dov88154

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THIS DEED is made the 22nd day of AUGUST 2005 BETWEEN (1) THE KENT COUNTY
COUNCIL of County Hall Maidstone Kent ME14 1XQ ("the Landlord") and (2) GENZYME
LIMITED of 50 Gibson Drive Kings Hill West Malling Kent ME19 4AF ("the Tenant")

1 DEFINITIONS AND INTERPRETATION

In this deed:

1.1     "the Lease" means a lease dated 19th January 2001 and made between (1)
        Liberty Property Limited Partnership (2) the Tenant and (3) Kings Hill
        Estate Management Company Limited

1.2     the clause headings do not form part of this deed and shall not be taken
        into account in its construction or interpretation

2 RECITALS

2.1     This deed is supplemental to the Lease

2.2     The parties desire to alter the terms of the Lease as mentioned below

3 ALTERATIONS TO TERMS

It is mutually agreed that as from the date hereof the amendments and variations
set out in the Schedule hereto shall be deemed to have been made to the Lease
and that the Lease shall henceforth be read and construed with such amendments
and variations

4 CONFIRMATION OF THE LEASE

The Lease shall continue in full force save as modified by this deed and shall
from the date hereof operate as if the amendments and variations contained in
this deed were incorporated in lieu of the provisions for which they are
substituted and the covenants conditions and provisions of the Lease shall have
effect as though the amendments and variations contained in this deed had been
originally contained in the Lease

IN WITNESS of which this deed has been executed the day and year first before
written

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                                  THE SCHEDULE

1.      Clause 8 shall be amended so that the date of 23 June 2011 shall be
        inserted instead of 24 June 2006

2.      In Clause 8 the words "a sum equivalent to ..... preceding the Break
        Date" in the 7th and 8th lines shall be replaced with "the sum of
        two hundred twenty thousand pounds"

3.      The rent firstly reserved for the year commencing on 24 June 2005 shall
        be two hundred twelve thousand five hundred pounds (exclusive of VAT)

4.      The rent firstly reserved for the year commencing 24 June 2006 and
        thereafter shall be two hundred twenty thousand pounds (exclusive of
        VAT) subject to review as mentioned in paragraph 5 hereof

5.      The Rent Review Date (as defined in the Lease) shall be amended so that
        the date of 23 June 2011 shall be inserted instead of 24th June 2006

THE COMMON SEAL of
THE KENT COUNTY COUNCIL
was hereunto affixed in the
presence of:-

         /s/ illegible
------------------------------------
An Authorised Signatory

THE COMMON SEAL of
GENZYME LIMITED
was hereunto affixed in
the presence of:-

Director                  /s/ Paul J. O'Connor
                       ------------------------

Director/Secretary:         /s/ T. Harrow
                       ------------------------

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                 DATED             22nd AUGUST             2005
                 ----------------------------------------------

                             THE KENT COUNTY COUNCIL

                                       and

                                 GENZYME LIMITED

                 ----------------------------------------------

                               AGREEMENT FOR LEASE

                 50 Gibson Drive, Kings Hill, West Malling, Kent

                  ---------------------------------------------

                               Ref: LS/A/88154/17
                        WP Ref: BEACH/LEASES/agrlse 88154

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THIS AGREEMENT FOR LEASE made the 22nd day of August 2005 BETWEEN THE KENT
COUNTY COUNCIL of County Hall Maidstone Kent ME14 1XQ ("the Landlord") of the
one part and GENZYME LIMITED of 50 Gibson Drive Kings Hill West Malling Kent
ME19 4AF ("the Tenant") of the other part WHEREBY it is agreed as follows:

1.      DEFINITIONS AND INTERPRETATIONS:

1.1     "the Premises" means the premises described in the Lease dated 19th
        January 2001 made between (1) Liberty Property Limited Partnership (2)
        the Tenant and (3) Kings Hill Estate Management Company Limited as
        varied by a Deed of Variation dated 2005 amending the terms of that
        Lease ("the Lease")

1.2     "Completion Date" means 24th June 2011 (subject to the Proviso contained
        in clause 2.1 hereof)

1.3     The Clause headings do not form part of this Agreement and shall not be
        taken into account in its construction or interpretation

2.      GRANT AND COMPLETION

2.1     The Landlord shall with full title guarantee grant and the Tenant shall
        accept a new lease of the Premises on the Completion Date on the same
        terms and conditions as are contained in the Lease save for the
        variations set out in the Schedule hereto and mentioned in clause 5.2
        hereof PROVIDED that the Tenant shall have by the Completion Date served
        written notice on the Landlord that the Tenant desires to take the new
        lease but if the Tenant shall not serve the notice then the provisions
        of this Agreement shall automatically determine and become void and of
        no further effect on 24th June 2011

2.2     The new lease shall be completed on the Completion Date at the offices
        of the Landlord's solicitor or such other place as the Landlord's
        solicitor shall reasonably require

2.3     At any time on or after the Completion Date any party being ready and
        willing to complete the new lease and perform its other obligations
        under this Agreement may (but without prejudice to any other available
        rights or remedy) by notice to the other invoke the provisions of Clause
        2.4

2.4     Within 10 working days after service of such a Notice (excluding the day
        of service) the new

                                       -1-
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        lease shall be completed and the parties shall perform their obligations
        under this Agreement and time shall be of the essence of this provision

3.      VACANT POSSESSION AND RENT

3.1     Vacant possession of the demise of the Premises shall be given to the
        Tenant on completion of the new lease

3.2     If the new lease is completed rent shall be payable in accordance with
        the terms of the new lease

3.3     The Tenant shall on or before completion of the new lease pay to the
        Landlord all arrears of rent and service charge due to the Landlord
        under the Lease

3.4     If the new Lease is completed the Landlord shall waive the requirements
        of clause 4.21 of the Lease (yield up) provided identical provisions are
        included in the new Lease and any other obligations to reinstate works
        or alterations on the part of the Tenant whether under the Lease or any
        document supplemental to it shall be postponed to the expiry or sooner
        determination of the new Lease

4.      DAMAGE

4.1     No damage to or destruction of the Premises or any part of them
        occurring after the date of this Agreement however occasioned shall in
        any way affect the obligations of the parties under this Agreement

5.      TITLE AND CONDITION

5.1     The Tenant having previously been in occupation of the Premises shall
        not raise any requisitions or objections in respect of the Landlord's
        title

5.2     The Premises shall be demised subject to all matters set out in the
        Lease (as subsequently varied) (as if they were repeated in full in the
        new lease with such modifications as are necessary to make them
        applicable to the new lease) and all matters registered or capable of
        registration as Local Land Charges and the Tenant admits that it has
        entered into this Agreement with Notice of the same and shall raise no
        objection requisition or enquiry in respect thereof

                                       -2-
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5.3     The Tenant has entered into this Agreement with Notice of the actual
        state and condition of the Premises and shall take the same as they are

6.      NO ASSIGNMENT POSSESSION ETC

6.1     The Tenant shall not assign underlet charge or otherwise deal with the
        benefit of this Agreement in whole or in part and the Landlord shall not
        be obliged to grant the new lease to any person other than the Tenant
        except that the Tenant may assign the benefit of this Agreement to any
        person body or company to whom it shall have assigned or sublet the
        Demised Premises by the Lease in accordance with the provision of
        clauses 4.10 and 4.11 of the Lease

6.2     This Agreement is an executory Agreement only and shall not operate to
        be or be deemed to operate as a demise of the Premises

6.3     From the expiration of the Lease and until completion of the new lease
        (if there shall be a gap) the Tenant shall be the Tenant-at-Will of the
        Landlord in respect of the Premises subject to all covenants and
        conditions on the part of the Tenant contained in the new lease

7.      NOTICES AND NON-MERGER

7.1     Any notice served in accordance with this Agreement shall be in writing
        and may (in addition to any other effective mode of service) be sent by
        registered or recorded delivery post to the relevant party

7.2     Any notice given by or to any party in accordance with this Agreement
        may be given by or to that party's solicitors

7.3     To the extent that they remain to be observed and performed all of the
        provisions of this Agreement shall continue in full force and effect
        notwithstanding completion of the new Lease

8.      EXCLUSION OF SECTIONS 24 TO 28 OF THE 1954 ACT

8.1     Pursuant to Section 38A(1) of the Landlord and Tenant Act 1954 as
        inserted by the Regulatory Reform (Business Tenancies) (England and
        Wales) Order 2003 ("the Order") the parties agree that the provisions of
        Sections 24 to 28 inclusive of the Landlord and Tenant Act 1954 shall be
        excluded in relation to the new lease

                                       -3-
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8.2     For the purposes of Section 38A(3) of the Landlord and Tenant Act 1954
        as inserted by the Order and Schedule 2 to the Order the parties confirm
        that:

        8.2:1   the Landlord served on the Tenant on 28 June 2005 a notice in
                the form or substantially in the form set out in Schedule 1 to
                the Order in relation to the tenancy to be created by the new
                lease before the Tenant entered into this Agreement

        8.2:2   Paul O'Connor who was duly authorised by the Tenant to do so
                made in relation to the notice referred to in clause 8.2:1 above
                a statutory declaration dated 7 July 2005 in the form or
                substantially in the form set out in paragraph 8 of Schedule 2
                to the Order before the Tenant entered into this Agreement

8.3     The Tenant confirms that Paul O'Connor was duly authorised to make the
        statutory declaration referred to in clause 8.2:2 above on its behalf

8.4     The new lease shall contain an agreement in similar terms to clause 8.1
        above and the parties shall serve all such notices and complete all such
        declarations and other documents and carry out all such procedures as
        shall at that time be necessary to enable such an agreement to be
        validly entered into

                                  THE SCHEDULE

1.      The Lease shall be between the parties hereto or their successors in
        title

2.      The Term shall be from and including 24th June 2011 to and including
        23rd June 2016

3.      The rent for the new lease shall be two hundred twenty thousand pounds
        per year or such rent as shall be determined in accordance with the
        provisions for rent review on 23rd June 2011 contained in the Lease
        [but the procedure therefore shall commence at any time after
        25th December 2010 by the Landlord suggesting to the Tenant the amount
        of the new rent]

SIGNED:             /s/ illegible
           ----------------------------------------

For and on behalf of the Landlord

                                       -4-
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Authorised Signatory

SIGNED:     /s/ Paul J. O'Connor
        -------------------------------

For and on behalf of the Tenant

                                       -5-<PAGE>

                                                                    Exhibit 10.3

                       FIFTH AMENDMENT TO LEASE AGREEMENT

     FIFTH AMENDMENT TO LEASE AGREEMENT (the "Fifth Amendment") dated as of
October 28, 2005 among and between Wells Fargo Bank Northwest, N.A. (f/k/a First
Security Bank, N.A.), not in its individual capacity except as expressly set
forth in the Agency Agreement, but solely as Trustee under the Owner Trust
Agreement dated as of October 21, 1998 (the "Lessor") and Genzyme Corporation,
as successor-by-merger to GelTex Pharmaceuticals, Inc. (the "Lessee").

     Reference is made to the Lease Agreement dated as of October 21, 1998,
among and between the Lessor and GelTex Pharmaceuticals, Inc., pursuant to which
the Lessee leases from the Lessor a certain parcel of land located in Waltham,
Massachusetts, described in Exhibit A to the Lease Agreement, together with all
buildings, structures, improvements, fixtures, other real or personal property
described in the Lease Agreement and all easements, rights and appurtenances
thereto, as amended by that certain First Amendment to Lease Agreement dated
March 31, 1999, that certain Second Amendment to Lease Agreement dated December
31, 2000, that certain Third Amendment to Lease Agreement dated January 14,
2004, and that certain Fourth Amendment to Lease Agreement (the "Fourth
Amendment") dated June 30, 2004 (the "Lease Agreement"). Capitalized terms used
in this Fifth Amendment have the meanings given such terms in the Lease
Agreement, as amended hereby, except as provided otherwise herein.

     The Lessor and Lessee entered into the Fourth Amendment with the intention
that certain modifications would be made to the manner in which Equity Return is
calculated under the Lease Agreement. Due to a clerical error, language was
dropped from the definition of LIBOR Rate in the Fourth Amendment. This Fifth
Amendment is intended to properly reflect both the intent of the Lessor and
Lessee and the actual practice of the Lessor and Lessee since June 30, 2004, the
effective date of the Fourth Amendment, in the calculation of LIBOR Rate.

     The Lessee has requested that Lessor, Banc of America Leasing & Capital,
LLC (f/k/a Fleet Capital Corporation, transferee of Fleet Real Estate, Inc.) and
Bank of America, N.A. (successor-by-merger to Fleet National Bank) agree to the
correction in the Lease Agreement set forth below.

     NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereby agree as
follows subject to the terms and conditions of the Lease Agreement:

     1. SECTION 5 OF SCHEDULE B. Section 5 ("Definitions") of Schedule B ("Basic
Rent") of the Lease Agreement is hereby amended to strike and delete in its
entirety the definition of "LIBOR Rate" and replace it with the following in
lieu thereof, which amendment shall have retroactive effect to June 30, 2004 :

          "LIBOR RATE means, with respect to each applicable LIBOR Period, the
     sum of (1) the Adjusted LIBOR applicable to such LIBOR Period PLUS (2) the
     Applicable Margin."

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     2. Except as amended hereby, the Lease Agreement shall remain in full force
and effect in accordance with its original terms.

     3. This Fifth Amendment shall be deemed to be an Operative Document under
the Lease Agreement.

                  [Remainder of Page Intentionally Left Blank]

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     IN WITNESS WHEREOF, this Fifth Amendment has been duly executed and
delivered as a sealed instrument at Boston, Massachusetts as of the date first
above written.

                                LESSOR:

                                WELLS FARGO BANK NORTHWEST, N.A. (formerly known
                                as FIRST SECURITY BANK, N.A.) not in its
                                individual capacity except as expressly set
                                forth herein, but solely as Trustee under the
                                Owner Trust Agreement dated as of October 21,
                                1998

                                By: /s/ Val T. Orton
                                    -------------------------------------------
                                    Name: Val T. Orton
                                    Title: Vice President

                                LESSEE:

                                GENZYME CORPORATION

                                By: /s/ Evan Lebson
                                    -------------------------------------------
                                    Name: Evan Lebson
                                    Title: Vice President and Treasurer

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                                AGREED AND ACCEPTED:

                                BANK OF AMERICA, N.A.
                                (successor-by-merger to Fleet National Bank)

                                By: /s/ Richard C. Hardison
                                    -------------------------------------------
                                    Name: Richard C. Hardison
                                    Title: Vice President

                                BANC OF AMERICA LEASING & CAPITAL, LLC
                                (f/k/a Fleet Capital Corporation, transferee of
                                Fleet Real Estate, Inc.)

                                By: /s/ Cheryl A. Valcourt
                                    -------------------------------------------
                                    Name: Cheryl A. Valcourt
                                    Title: Vice President

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