Document:

exv4w1

Exhibit 4.1

XENOPORT, INC.

WARRANT TO PURCHASE [____] SHARES OF COMMON STOCK

Date of Issuance: [______] [__], 200__

VOID AFTER [______] [__], 200__

     This Certifies That, for value received, [___], or permitted registered assigns (the
“Holder”), is entitled to subscribe for and purchase at the Exercise Price (defined below) from
XenoPort, Inc., a Delaware corporation (the “Company”), up to [___] shares of the common stock of
the Company, par value $.001 per share (the “Common Stock”). This warrant is one of a series of
warrants issued by the Company as of the date hereof (individually a “Warrant”; collectively,
“Company Warrants”) pursuant to those certain purchase agreements between the Company and each of
the Investors, each dated as of December 30, 2008 (each, a “Purchase Agreement”).

     1. Definitions. Capitalized terms used herein but not otherwise defined herein shall
have their respective meanings as set forth in the Purchase Agreement. As used herein, the
following terms shall have the following respective meanings:

          (A) “Eligible Market” means any of the New York Stock Exchange, the American Stock Exchange,
The NASDAQ Global Market, The NASDAQ Global Select Market or The NASDAQ Capital Market.

          (B) “Exercise Period” shall mean the period ending five years from the date hereof, unless
sooner terminated as provided below.

          (C) “Exercise Price” shall mean $25.40 per share, subject to adjustment pursuant to Section 4
below.

          (D) “Exercise Shares” shall mean the shares of Common Stock issuable upon exercise of this
Warrant.

          (E) “Fundamental Transaction” means that the Company shall, directly or indirectly, in one or
more related transactions, (i) consolidate or merge with or into (whether or not the Company is the
surviving corporation) another Person, or (ii) sell, assign, transfer, convey or otherwise dispose
of all or substantially all of the properties or assets of the Company to another Person, or (iii)
enter into an agreement with another Person pursuant to which such Person agrees to make a
purchase, tender or exchange offer that is accepted by the holders of more than the 50% of the
outstanding shares of Common Stock (not including any shares of Common Stock held by the Person or
Persons making or party to, or associated or affiliated with the Persons making or party to, such
purchase, tender or exchange offer), or (iv) consummate a stock purchase agreement or other
business combination (including, without limitation, a reorganization, recapitalization, spin-off
or scheme of arrangement) with another Person

 

 

whereby such other Person acquires more than the 50% of the outstanding shares of Common Stock
(not including any shares of Common Stock held by the other Person or other Persons making or party
to, or associated or affiliated with the other Persons making or party to, such stock purchase
agreement or other business combination), (v) reorganize, recapitalize or reclassify its Common
Stock, or (vi) any “person” or “group” (as these terms are used for purposes of Sections 13(d) and
14(d) of the Exchange Act) is or shall become the “beneficial owner” (as defined in Rule 13d-3
under the Exchange Act), directly or indirectly, of 50% of the aggregate ordinary voting power
represented by issued and outstanding Common Stock.

          (F) “Parent Entity” of a Person means an entity that, directly or indirectly, controls the
applicable Person and whose common stock or equivalent equity security is quoted or listed on The
New York Stock Exchange, Inc. or an Eligible Market, or, if there is more than one such Person or
Parent Entity, the Person or Parent Entity with the largest public market capitalization as of the
date of consummation of the Fundamental Transaction.

          (G) “Person” means an individual, a limited liability company, a partnership, a joint venture,
a corporation, a trust, an unincorporated organization, any other entity and a government or any
department or agency thereof.

          (H) “Successor Entity” means the Person (or, if so elected by the Holder, the Parent Entity)
formed by, resulting from or surviving any Fundamental Transaction or the Person (or, if so elected
by the Holder, the Parent Entity) with which such Fundamental Transaction shall have been entered
into.

          (I) “Trading Day” shall mean (a) any day on which the Common Stock is listed or quoted and
traded on its primary Trading Market, (b) if the Common Stock is not then listed or quoted and
traded on any Eligible Market, then a day on which trading occurs on the OTC Bulletin Board (or any
successor thereto), or (c) if trading does not occur on the OTC Bulletin Board (or any successor
thereto), any Business Day.

          (J) “Trading Market” shall mean the OTC Bulletin Board or any other Eligible Market, or any
national securities exchange, market or trading or quotation facility on which the Common Stock is
then listed or quoted.

     2. Exercise of Warrant.

          2.1 Exercise. The rights represented by this Warrant may be exercised in whole or in part at
any time during the Exercise Period, by delivery of the following to the Company at its address set
forth on the signature page hereto (or at such other address as it may designate by notice in
writing to the Holder):

          (A) An executed Notice of Exercise in the form attached hereto;

          (B) Payment of the Exercise Price either (i) in cash or by check or (ii) pursuant to Section
2.2 below; and

          (C) This Warrant.

 

 

          Execution and delivery of the Notice of Exercise shall have the same effect as cancellation of
the original Warrant and issuance of a new Warrant evidencing the right to purchase the remaining
number of Exercise Shares, if any.

     Certificates for shares purchased hereunder shall be transmitted by the transfer agent of the
Company to the Holder by crediting the account of the Holder’s prime broker with the Depository
Trust Company through its Deposit Withdrawal Agent Commission system if the Company is a
participant in such system, and otherwise by physical delivery to the address specified by the
Holder in the Notice of Exercise within three business days from the delivery to the Company of the
Notice of Exercise, surrender of this Warrant and payment of the aggregate Exercise Price as set
forth above. This Warrant shall be deemed to have been exercised on the date the Exercise Price is
received by the Company.

     The person in whose name any certificate or certificates for Exercise Shares are to be issued
upon exercise of this Warrant shall be deemed to have become the holder of record of such shares on
the date on which this Warrant was surrendered and payment of the Exercise Price was made,
irrespective of the date of delivery of such certificate or certificates, except that, if the date
of such surrender and payment is a date when the stock transfer books of the Company are closed,
such person shall be deemed to have become the holder of such shares at the close of business on
the next succeeding date on which the stock transfer books are open.

     Subject to the final sentence of this paragraph and to the extent permitted by law, the
Company’s obligations to issue and deliver Exercise Shares in accordance with the terms hereof are
absolute and unconditional, irrespective of any action or inaction by the Holder to enforce the
same, any waiver or consent with respect to any provision hereof, the recovery of any judgment
against any person or entity or any action to enforce the same, or any setoff, counterclaim,
recoupment, limitation or termination, or any breach or alleged breach by the Holder or any other
person or entity of any obligation to the Company or any violation or alleged violation of law by
the Holder or any other person or entity, and irrespective of any other circumstance which might
otherwise limit such obligation of the Company to the Holder in connection with the issuance of
Exercise Shares. The Holder shall, subject to the following proviso, have the right to pursue any
remedies available to it hereunder, at law or in equity including, without limitation, a decree of
specific performance and/or injunctive relief with respect to the Company’s failure to timely
deliver Exercise Shares upon exercise of this Warrant as required pursuant to the terms hereof;
provided, however, that notwithstanding anything to the contrary in this Warrant or in the Purchase
Agreements, if the Company is for any reason unable to deliver Exercise Shares upon exercise of
this Warrant as required pursuant to the terms hereof, the Company shall have no obligation to pay
to the Holder any cash or other consideration or otherwise “net cash settle” this Warrant.

     Except for cash in lieu of fractional shares as provided in Section 5, this Warrant may not be
settled by the Company for cash to the Holder in lieu of Common Stock.

          2.2 Net Exercise. If during the Exercise Period the fair market value of one share of the
Common Stock is greater than the Exercise Price (at the date of calculation as set forth below), in
lieu of exercising this Warrant by payment of cash or by check, the Holder may, at its election,
effect a “net exercise” of this Warrant, in which event, if so effected, the Holder

 

 

shall receive Exercise Shares equal to the value (as determined below) of this Warrant (or the
portion thereof being canceled) by surrender of this Warrant at the principal office of the
Company, together with the properly endorsed Notice of Exercise, in which event the Company shall
issue to the Holder a number of shares of Common Stock computed using the following formula:

Where X = the number of Exercise Shares to be issued to the Holder

	 	 	Y = the number of Exercise Shares with respect to which this Warrant is being
exercised
	 
	 	 	A = the Fair Market Value (as defined below) of one share of the Company’s Common
Stock (at the date of such calculation)
	 
	 	 	B = Exercise Price (as adjusted to the date of such calculation)

     For purposes of this Warrant, the “Fair Market Value” of one share of Common Stock shall mean
(i) the average of the closing sales prices for the shares of Common Stock on The NASDAQ Global
Market or other Eligible Market where the Common Stock is listed or traded as reported by Bloomberg
Financial Markets (or a comparable reporting service of national reputation selected by the Company
and reasonably acceptable to the Holder if Bloomberg Financial Markets is not then reporting sales
prices of such security) (collectively, “Bloomberg”) for the ten (10) consecutive trading days
immediately prior to the Exercise Date, or (ii) if an Eligible Market is not the principal Trading
Market for the shares of Common Stock, the average of the reported sales prices reported by
Bloomberg on the principal Trading Market for the Common Stock during the same period, or, if there
is no sales price for such period, the last sales price reported by Bloomberg for such period, or
(iii) if neither of the foregoing applies, the last sales price of such security in the
over-the-counter market on the pink sheets or bulletin board for such security as reported by
Bloomberg, or if no sales price is so reported for such security, the last bid price of such
security as reported by Bloomberg or (iv) if fair market value cannot be calculated as of such date
on any of the foregoing bases, the fair market value shall be as determined by the Board of
Directors of the Company in the exercise of its good faith judgment.

          2.3 Issuance Of New Warrants. Upon any partial exercise of this Warrant, the Company, at its
expense, will forthwith and, in any event within five business days, issue and deliver to the
Holder a new warrant or warrants of like tenor, registered in the name of the Holder, exercisable,
in the aggregate, for the balance of the number of shares of Common Stock remaining available for
purchase under this Warrant.

          2.4 Payment Of Taxes And Expenses. The Company shall pay any recording, filing, stamp or
similar tax which may be payable in respect of any transfer involved in the issuance of, and the
preparation and delivery of certificates (if applicable) representing, (i) any Exercise Shares
purchased upon exercise of this Warrant and/or (ii) new or replacement warrants in the Holder’s
name or the name of any transferee of all or any portion of this Warrant; provided, however, that
the Company shall not be required to pay any tax which may be payable in respect of any transfer
involved in the issuance, delivery or registration of any certificates for

 

 

Exercise Shares or Warrants in a name other than that of the Holder. The Holder shall be
responsible for all other tax liability that may arise as a result of holding or transferring this
Warrant or receiving Exercise Shares upon exercise hereof.

     3. Covenants of the Company. 

          3.1 Covenants as to Exercise Shares. The Company covenants and agrees that all Exercise
Shares that may be issued upon the exercise of the rights represented by this Warrant will, upon
issuance, be validly issued and outstanding, fully paid and nonassessable, and free from all taxes,
liens and charges with respect to the issuance thereof. The Company further covenants and agrees
that the Company will at all times during the Exercise Period, have authorized and reserved, free
from preemptive rights, a sufficient number of shares of Common Stock to provide for the exercise
of the rights represented by this Warrant. If at any time during the Exercise Period the number of
authorized but unissued shares of Common Stock shall not be sufficient to permit exercise of this
Warrant, the Company will use its commercially reasonable efforts to take such corporate action in
compliance with applicable law as may, in the opinion of its counsel, be necessary to increase its
authorized but unissued shares of Common Stock to such number of shares as shall be sufficient for
such purposes.

          3.2 Notices of Record Date and Certain Other Events. In the event of any taking by the
Company of a record of the holders of any class of securities for the purpose of determining the
holders thereof who are entitled to receive any dividend or other distribution, the Company shall
mail to the Holder, at least fifteen (15) days prior to the date on which any such record is to be
taken for the purpose of such dividend or distribution, a notice specifying such date. In the
event of any voluntary dissolution, liquidation or winding up of the Company, the Company shall
mail to the Holder, at least fifteen (15) days prior to the date of the occurrence of any such
event, a notice specifying such date. In the event the Company authorizes or approves, enters into
any agreement contemplating, or solicits stockholder approval for any Fundamental Transaction, as
defined in Section 6 herein, the Company shall mail to the Holder, at least fifteen (15) days prior
to the date of the closing of such event, a notice specifying such date. Notwithstanding the
foregoing, the failure to deliver such notice or any defect therein shall not affect the validity
of the corporate action required to be described in such notice.

     4. Adjustment of Exercise Price and Shares. 

     The Exercise Price and number of Exercise Shares issuable upon exercise of this Warrant are
subject to adjustment from time to time as set forth in this Section 4.

          (A) If the Company, at any time while this Warrant is outstanding, (i) pays a stock dividend
on its Common Stock or otherwise makes a distribution on any class of capital stock that is payable
in shares of Common Stock, (ii) subdivides outstanding shares of Common Stock into a larger number
of shares, or (iii) combines outstanding shares of Common Stock into a smaller number of shares,
then in each such case the Exercise Price shall be multiplied by a fraction of which the numerator
shall be the number of shares of Common Stock outstanding immediately before such event and of
which the denominator shall be the number of shares of Common Stock outstanding immediately after
such event. Any adjustment made pursuant to clause (i) of this paragraph shall become effective
immediately after the record date for the

 

 

determination of stockholders entitled to receive such dividend or distribution, and any
adjustment pursuant to clause (ii) or (iii) of this paragraph shall become effective immediately
after the effective date of such subdivision or combination.

          (B) If the Company, at any time while this Warrant is outstanding, distributes to holders of
Common Stock (i) evidences of its indebtedness, (ii) any security (other than a distribution of
Common Stock covered by the preceding paragraph), (iii) rights or warrants to subscribe for or
purchase any security, or (iv) any other asset (in each case, “Distributed Property”), then in each
such case the Holder shall be entitled upon exercise of this Warrant for the purchase of any or all
of the Exercise Shares, to receive the amount of Distributed Property which would have been payable
to the Holder had such Holder been the holder of such Exercise Shares on the record date for the
determination of stockholders entitled to such Distributed Property. The Company will at all times
set aside in escrow and keep available for distribution to such holder upon exercise of this
Warrant a portion of the Distributed Property to satisfy the distribution to which such Holder is
entitled pursuant to the preceding sentence.

          (C) Upon the occurrence of each adjustment pursuant to this Section 4, the Company at its
expense will, at the written request of the Holder, promptly compute such adjustment in accordance
with the terms of this Warrant and prepare a certificate setting forth such adjustment, including a
statement of the adjusted Exercise Price and adjusted number or type of Exercise Shares or other
securities issuable upon exercise of this Warrant (as applicable), describing the transactions
giving rise to such adjustments and showing in detail the facts upon which such adjustment is
based. Upon written request, the Company will promptly deliver a copy of each such certificate to
the Holder and to the Company’s transfer agent.

     5. Fractional Shares. No fractional shares shall be issued upon the exercise of this
Warrant as a consequence of any adjustment pursuant hereto. All Exercise Shares (including
fractions) issuable upon exercise of this Warrant may be aggregated for purposes of determining
whether the exercise would result in the issuance of any fractional share. If, after aggregation,
the exercise would result in the issuance of a fractional share (a) the Company shall, in lieu of
issuance of any fractional share, pay the Holder otherwise entitled to such fraction a sum in cash
equal to the product resulting from multiplying the then-current fair market value of an Exercise
Share by such fraction and (b) the number of Exercise Shares to be issued will be rounded down to
the nearest whole share.

     6. Fundamental Transactions. The Company shall not enter into or be party to a
Fundamental Transaction unless the Successor Entity assumes this Warrant in accordance with the
provisions of this Section 6. Upon the occurrence of any Fundamental Transaction, the Successor
Entity shall succeed to, and be substituted for (so that from and after the date of such
Fundamental Transaction, the provisions of this Warrant referring to the “Company” shall refer
instead to the Successor Entity), and may exercise every right and power of the Company and shall
assume all of the obligations of the Company under this Warrant with the same effect as if such
Successor Entity had been named as the Company herein. Prior to the consummation of any Fundamental
Transaction pursuant to which holders of shares of Common Stock are entitled to receive securities
or other assets with respect to or in exchange for shares of Common Stock (a “Corporate Event”),
the Company shall make appropriate provision to insure that the Holder will thereafter have the
right to receive upon an exercise of this Warrant at any time after the

 

 

consummation of the Fundamental Transaction but prior to the Expiration Date, in lieu of the
Exercise Shares (or other securities, cash, assets or other property) purchasable upon the exercise
of the Warrant prior to such Fundamental Transaction, such shares of stock, securities, cash,
assets or any other property whatsoever (including warrants or other purchase or subscription
rights) which the Holder would have been entitled to receive upon the happening of such Fundamental
Transaction had the Warrant been exercised immediately prior to such Fundamental Transaction.
Provision made pursuant to the preceding sentence shall be in a form and substance reasonably
satisfactory to the Holder. The provisions of this Section 6 shall apply similarly and equally to
successive Fundamental Transactions and Corporate Events and shall be applied without regard to any
limitations on the exercise of this Warrant.

     7. No Stockholder Rights. Other than as provided in Section 3.2 or otherwise herein,
this Warrant in and of itself shall not entitle the Holder to any voting rights or other rights as
a stockholder of the Company.

     8. Transfer of Warrant. Subject to applicable laws and any restrictions on transfer
set forth in the Purchase Agreement, this Warrant and all rights hereunder are transferable, by the
Holder in person or by duly authorized attorney, upon delivery of this Warrant and the form of
assignment attached hereto to any transferee designated by Holder. The transferee shall sign an
investment letter in form and substance reasonably satisfactory to the Company and its counsel.
Any purported transfer of all or any portion of this Warrant in violation of the provisions of this
Warrant shall be null and void.

     9. Lost, Stolen, Mutilated or Destroyed Warrant. If this Warrant is lost, stolen,
mutilated or destroyed, the Company may, on such terms as to indemnity or otherwise as it may
reasonably impose (which shall, in the case of a mutilated Warrant, include the surrender thereof),
issue a new Warrant of like denomination and tenor as this Warrant so lost, stolen, mutilated or
destroyed. Any such new Warrant shall constitute an original contractual obligation of the
Company, whether or not the allegedly lost, stolen, mutilated or destroyed Warrant shall be at any
time enforceable by anyone.

     10. Notices, Etc. All notices required or permitted hereunder shall be in writing
and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b)
when sent by confirmed facsimile to the facsimile number specified in writing by the recipient if
sent during normal business hours of the recipient on a Trading Day, if not, then on the next
Trading Day, (c) the next Trading Day after deposit with a nationally recognized overnight courier,
specifying next day delivery, with written verification of receipt. All communications shall be
sent to the Company at the address listed on the signature page hereto and to Holder at the
applicable address set forth on the applicable signature page to the Purchase Agreement or at such
other address as the Company or Holder may designate by ten (10) days advance written notice to the
other parties hereto.

     11. Acceptance. Receipt of this Warrant by the Holder shall constitute acceptance of
and agreement to all of the terms and conditions contained herein.

     12. Governing Law. This Warrant and all rights, obligations and liabilities
hereunder shall be governed by, and construed in accordance with, the internal laws of the State

 

 

of California, without giving effect to the principles of conflicts of law that would require
the application of the laws of any other jurisdiction.

     13. Amendment or Waiver. Any term of this Warrant may be amended or waived (either
generally or in a particular instance and either retroactively or prospectively) with the written
consent of the Company and the Holder. No waivers of any term, condition or provision of this
Warrant, in any one or more instances, shall be deemed to be, or construed as, a further or
continuing waiver of any such term, condition or provision.

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

 

 

     In Witness Whereof, the Company has caused this Warrant to be executed by its duly
authorized officer as of [___] [___], 200___.

	 	 	 	 	 	 	 
	 	 	XENOPORT, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 

Name: [                    ]
	 	 
	 

	 	 	 	Title: [                    ]	 	 
	 
	 	 	 	 	 	 
	 	 	3410 Central Expressway	 	 
	 	 	Santa Clara, California 95051	 	 

 

 

NOTICE OF EXERCISE

TO: XENOPORT, INC.

     (1) The undersigned hereby elects to purchase [___] shares of the common stock, par value
$.001 (the “Common Stock”), of XENOPORT, INC. (the “Company”) pursuant to the terms of the attached
Warrant, and tenders herewith payment of the exercise price in full, together with all applicable
transfer taxes, if any.

     [_] The undersigned hereby elects to purchase [___] shares of Common Stock of the
Company pursuant to the terms of the net exercise provisions set forth in Section 2.2 of the
attached Warrant, and shall tender payment of all applicable transfer taxes, if any.

     (2) Please issue the certificate for shares of Common Stock in the name of:

 

Print or type name

 

Social Security or other Identifying Number

 

Street Address

 

City State Zip Code

     (3) If such number of shares shall not be all the shares purchasable upon the exercise of the
Warrants evidenced by this Warrant, a new warrant certificate for the balance of such Warrants
remaining unexercised shall be registered in the name of and delivered to:

          Please insert social security or other identifying number:                     

 

(Please print name and address)

Dated:

(Date)

	 	 	 
	 

	 	 
	 

	 	(Signature)
	 
	 	 
	 

	 	 
	 

	 	(Print name)

 

 

ASSIGNMENT FORM

     (To assign the foregoing Warrant, execute this form and supply required information. Do not
use this form to purchase shares.)

     FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned
to

	 	 	 
	Name:
	 	 
	 

	 	 
	 

	 	(Please Print)
	 
	 	 
	Address:
	 	 
	 

	 	 
	 

	 	(Please Print)

Dated:       , 20[__]

	 	 	 	 	 
	Holder’s Signature:
	 	 	 	 
	 

	 	 

	 	 
	 
	 	 	 	 
	Holder’s Address:
	 	 	 	 
	 

	 	 

	 	 

NOTE: The signature to this Assignment Form must correspond with the name as it appears on the face
of the Warrant, without alteration or enlargement or any change whatever. Officers of corporations
and those acting in a fiduciary or other representative capacity should file proper evidence of
authority to assign the foregoing Warrant.

1exv10w1

Exhibit 10.1

PURCHASE AGREEMENT

XenoPort, Inc.

3410 Central Expressway

Santa Clara, California 95051

Ladies and Gentlemen:

The undersigned (the “Investor”) hereby confirms its agreement with you as follows:

     1. This Purchase Agreement, including the Terms and Conditions For Purchase of Units attached
hereto as Annex I (collectively, this “Agreement”), is made as of the date set forth below between
XenoPort, Inc., a Delaware corporation (the “Company”), and the Investor. Capitalized terms not
defined herein shall have the meanings assigned to them in Annex I.

     2. The Company has authorized the sale and issuance to the Investor and [insert name of other
investors] of up to an aggregate of 1,889,467 units (the “Units”), with each Unit consisting of
(i) one share (the “Share,” collectively, the “Shares”) of its common stock, par value $0.001 per
share (the “Common Stock”), and (ii) one warrant (the “Warrant,” collectively, the “Warrants”) to
purchase 0.15 of a share of Common Stock (and the fractional amount being the “Warrant Ratio”), in
the form attached hereto as Exhibit B, for a purchase price of $21.17 per Unit (the
“Purchase Price”). Units will not be issued or certificated. The Shares and Warrants are
immediately separable and will be issued separately. The shares of Common Stock issuable upon
exercise of the Warrants are referred to herein as the “Warrant Shares” and, together with the
Units, the Shares and the Warrants, are referred to herein as the “Securities”.

     3. The offering and sale of the Units (the “Offering”) are being made pursuant to (1) an
effective Registration Statement on Form S-3 (File No. 333-156485 (including the Prospectus
contained therein (the “Base Prospectus”), the “Registration Statement”) filed by the Company with
the Securities and Exchange Commission (the “Commission”) on the date hereof, (2) the “free writing
prospectus” (as that term is defined in Rule 405 under the Securities Act of 1933, as amended (the
“Act”)), dated as of the date hereof (the “Issuer Free Writing Prospectus” and together with the
Base Prospectus, the “Time of Sale Prospectus”), containing certain supplemental information
regarding the Securities, the terms of the Offering and information that may be material to the
Company and its securities that has been or will be filed with the Commission, and that has been
delivered to the Investor on or prior to the date hereof, and (3) a Prospectus Supplement (the
“Prospectus Supplement” and together with the Base Prospectus, the “Prospectus”) containing certain
supplemental information regarding the Securities, the terms of the Offering and information that
may be material to the Company and its securities that will be filed with the Commission and
delivered to the Investor (or made available to the Investor by the filing by the Company of an
electronic version thereof with the Commission).

     4. The Company and the Investor agree that the Investor will purchase from the Company and the
Company will issue and sell to the Investor the Units set forth below for the aggregate purchase
price set forth below. The Units shall be purchased pursuant to the Terms and Conditions for
Purchase of Units attached hereto as Annex I and incorporated herein by this reference as if fully
set forth herein. The Investor acknowledges that the Offering is not being

- 1 -

 

underwritten [and that
there is no minimum offering amount]1 [and that the minimum offering amount is $40
million]2.

     5. The manner of settlement of the Shares included in the Units purchased by the Investor
shall be as follows. Shares will be delivered by crediting the account of the Investor’s prime
broker (as specified by such Investor on Exhibit A annexed hereto) with the Depository
Trust Company (“DTC”) through its Deposit/Withdrawal At Custodian (“DWAC”) system, whereby
Investor’s prime broker shall initiate a DWAC transaction on the Closing Date using its DTC
participant identification number, and released by BNY Mellon Shareowner Services, the Company’s
transfer agent (the “Transfer Agent”), at the Company’s direction. No later than the Closing, the
Investor shall:

	 	(i)	 	direct the broker-dealer at which the account or accounts to be credited
with the Shares are maintained to set up a DWAC instructing the Transfer Agent to
credit such account or accounts with the Shares, and
	 
	 	(ii)	 	remit by wire transfer the amount of funds equal to the aggregate
purchase price for the Units being purchased by the Investor to an account
designated in writing by the Company to the Investor no later than two business days
prior to the Closing (as defined in Annex I hereto).

     6. The executed Warrant included in the Units purchased by the Investor shall be delivered in
accordance with the terms thereof.

     The Investor represents that, except as set forth below, (a) it has had no position, office or
other material relationship within the past one year with the Company or persons known to it to be
affiliates of the Company, (b) it is not a broker dealer and (c) neither the Investor nor any group
of investors of which the Investor is a part that would be required to file a statement with the
Commission containing the information required by Schedule 13D or Schedule 13G regarding the same
Securities in connection with the Offering, acquired, or obtained the right to acquire, 20% or more
of the Common Stock (or securities convertible into or exercisable for Common Stock) or the voting
power of the Company on a post-transaction basis.

     7. The Investor represents that it has received (or otherwise had made available to it by the
filing by the Company of an electronic version thereof with the Commission) the Base Prospectus,
dated December 30, 2008, which is a part of the Company’s Registration Statement, the documents
incorporated by reference therein and the Issuer Free Writing Prospectus (collectively, the
“Disclosure Package”), which includes pricing and other information regarding the Offering (the
“Offering Information”), prior to or in connection with the receipt of this Agreement. The Investor
acknowledges that the Issuer Free Writing Prospectus included in the Disclosure Package contains
information that may be material to the Company and its securities that shall be disclosed to the
public by the Company in a Current Report on Form 8-K in accordance with Section 15 of Annex I
hereto, and the Investor agrees not to transact or agree to transact in the Company’s securities or
otherwise use such information until (a) the Company files with the Commission on December 30, 2008
a Current Report on Form 8-K in accordance

 

			
	1	 	Note: For Maverick, closing is not conditioned
on Venrock closing.
	 
	2	 	Note: For Venrock, closing is conditioned on
Maverick closing.

- 2 -

 

with Section 15 of Annex I hereto and (b) The NASDAQ
Global Market has opened for regular trading on December 30, 2008.

     8. No offer by the Investor to buy Units will be accepted and no part of the Purchase Price
will be delivered to the Company until the Investor has received the Disclosure Package including
the Offering Information and the Company has accepted such offer by countersigning a copy of this
Agreement, and any such offer may be withdrawn or revoked, without obligation or commitment of any
kind, at any time prior to the Company sending (orally, in writing or by electronic mail) notice of
its acceptance of such offer, provided that delivery of a copy of this Agreement countersigned by
or on behalf of the Company to the Investor shall constitute such notice. An indication of
interest will involve no obligation or commitment of any kind until the Investor has been delivered
the Disclosure Package including the Offering Information and this Agreement is accepted and
countersigned by or on behalf of the Company.

     9. This Agreement, including Annex I and the exhibits hereto, constitutes the entire agreement
of the parties to this Agreement and supersedes all prior written or oral and all contemporaneous
oral agreements, understandings and negotiations with respect to the subject matter hereof. In
this Agreement, the masculine, feminine and neuter genders and the singular and the plural include
one another.

- 3 -

 

	 	 	 	 	 
	Number of
Units:  

	 
	Purchase Price Per Unit:
	$	                    	 	 
	Aggregate Purchase Price:
	$	                    	 	 

     Please confirm that the foregoing correctly sets forth the agreement between us by signing in
the space provided below for that purpose.

	 	 	 	 	 
	 

	 	Dated as of:                     , 200___
	 
	 
	 	 	 
	 

	 	INVESTOR	 	 
	 
	 	 	 	 
	 

	 	By:  

	 

	 	Name:  

	 

	 	Title: 
	 	 
	 

	 	Address:  

	 
	 	 	 	 
	 	 	 

Agreed and Accepted

this ___day of ___, 200___:

XENOPORT, INC.

	 	 	 	 	 
	By: 

	 
	Name:
	 	 	 	 
	 

	 	 	 	 
	Title:
	 	 	 	 
	 

	 	 	 	 

[Signature Page to Purchase Agreement]

- 4 -

 

ANNEX I

TERMS AND CONDITIONS FOR PURCHASE OF UNITS

     1. Authorization and Sale of the Units. Subject to the terms and conditions of this
Agreement, the Company has authorized the sale of the Units, the Shares and the Warrants and the
issuance of the Warrant Shares upon exercise of the Warrants.

     2. Agreement to Sell and Purchase the Units.

          2.1 At the Closing (as defined in Section 3.1), the Company will sell to the Investor,
and the Investor will purchase from the Company, upon the terms and conditions set forth herein,
the number of Units set forth on the last page of the Agreement to which these Terms and Conditions
for Purchase of Units are attached as Annex I (the “Signature Page”) for the aggregate
purchase price therefor set forth on the Signature Page.

          2.2 The Company [proposes to]3 [shall] enter into substantially this same form of
Purchase Agreement with [insert name of other investors] (the “Other Investors”) [and expects to
complete the sale of the Units to the Other Investors] [on the date hereof, pursuant to which the
Company will agree to sell to the Other Investors, and the Other Investors will purchase from the
Company, simultaneously with the Closing, Units (each at the Purchase Price) for the aggregate
purchase price of $[ ] million]. The Investor and the Other Investors are hereinafter sometimes
collectively referred to as the “Investors,” and this Agreement and the Purchase Agreement executed
by the Other Investors are hereinafter sometimes collectively referred to as the “Agreements.”

     3. Closings and Delivery of the Units and Funds.

          3.1 Closing. The completion of the purchase and sale of the Units (the “Closing”)
shall take place at 9:00 a.m. Pacific Standard Time, on December 31, 2008 or at such other time as
the Company and the Investors shall agree, at the offices of Cooley Godward Kronish LLP, Five Palo
Alto Square, 3000 El Camino Real, Palo Alto, California 94306 (the “Closing Date”), in accordance
with Rule 15c6-1 promulgated under the Securities Exchange Act of 1934, as amended (the “Exchange
Act”). At the Closing, (a) the Company shall cause the Transfer Agent to deliver to the Investor
the number of Shares set forth on the Signature Page registered in the name of the Investor or, if
so indicated on the Investor Questionnaire attached hereto as Exhibit A, in the name of a nominee
designated by the Investor, (b) the Company shall cause to be delivered to the Investor a Warrant
to purchase a number of whole Warrant Shares determined by multiplying the number of Shares set
forth on the Signature Page by the Warrant Ratio and rounding down to the nearest whole number and
(c) the aggregate purchase price for the Units being purchased by the Investor set forth on the
Signature Page will be delivered by or on behalf of the Investor to the Company.

          3.2 Conditions to the Company’s Obligations. The Company’s obligation to issue and
sell the Units to the Investor shall be subject to: (i) the receipt by the Company of the purchase
price for the Units being purchased hereunder as set forth on the Signature Page and (ii) the
accuracy in all material respects of the representations and warranties made by the Investor and
the fulfillment of those undertakings of the Investor to be fulfilled prior to the Closing Date.

 

			
	3	 	Note: Language regarding simultaneous closings in this Section 2.2 is for Venrock only.

Annex I - 1 

 

          3.3 Conditions to the Investor’s Obligations. The Investor’s obligation to purchase
the Units will be subject to the accuracy of the representations and warranties of the Company
contained herein, to the accuracy of the statements of the Company made in any certificates
pursuant to the provisions hereof, to the performance by the Company of its obligations hereunder
and to each of the following additional terms and conditions. [The Investor’s obligations are
expressly not conditioned on the purchase by the Other Investors of the Units that it has agreed to
purchase from the Company.]4

               (a) No stop order suspending the effectiveness of the Registration Statement or any part
thereof, preventing or suspending the use of any Base Prospectus, the Prospectus or any Issuer Free
Writing Prospectus or any part thereof shall have been issued and no proceedings for that purpose
or pursuant to Section 8A under the Act shall have been initiated or threatened by the Commission,
and all requests for additional information on the part of the Commission (to be included or
incorporated by reference in the Registration Statement or the Prospectus or otherwise) shall have
been complied with to the reasonable satisfaction of the Investor; and each Issuer Free Writing
Prospectus and the Prospectus shall have been filed with the Commission within the applicable time
period prescribed for such filing by, and in compliance with, the published rules and regulations
under the Act (the “Rules and Regulations”).

               (b) The Investor shall not have discovered and disclosed to the Company, and the Company shall
not have discovered (which discovery, if any, the Company shall immediately disclose to the
Investor and counsel for the Investor), on or prior to the Closing Date that the Registration
Statement or any amendment or supplement thereto contains an untrue statement of a fact which, in
the opinion of counsel for the Investor, is material or omits to state any fact which, in the
opinion of such counsel, is material and is required to be stated therein or is necessary to make
the statements therein not misleading, or that the Disclosure Package, any Issuer Free Writing
Prospectus, or the Prospectus or any amendment or supplement thereto contains an untrue statement
of fact which, in the opinion of such counsel, is material or omits to state any fact which, in the
opinion of such counsel, is material and is necessary in order to make the statements, in the light
of the circumstances in which they were made, not misleading.

               (c) All corporate proceedings and other legal matters incident to the authorization, form and
validity of each of this Agreement, the Purchase Agreements, the Units, the Shares, the Warrants,
the Warrant Shares, the Registration Statement, the Disclosure Package, each Issuer Free Writing
Prospectus, if any, and the Prospectus and all other legal matters relating to this Agreement and
the transactions contemplated hereby shall be reasonably satisfactory in all material respects to
counsel for the Investor, and the Company shall have furnished to such counsel all documents and
information that they may reasonably request to enable them to pass upon such matters.

               (d) Cooley Godward Kronish LLP shall have furnished to the Investor such counsel’s written
opinion, as counsel to the Company, dated the Closing Date, in the form agreed as of the date
hereof.

               (e) The Company shall have furnished to Investor a certificate, dated the Closing Date, of its
Chief Executive Officer or President and its Chief Financial Officer stating that (i) since the
effective date of the Registration Statement, no event has occurred which should have been set
forth in a supplement or amendment to the Registration Statement, the Disclosure Package, the

 

			
	4	 	Note: Delete bracketed language for Venrock.

Annex I - 2 

 

Time
of Sale Prospectus, or the Prospectus, (ii) as of the Closing Date, the representations and
warranties of the Company in this Agreement are true and correct in all material respects, except
that any such representation or warranty shall be true and correct in all respects where such
representation or warranty is qualified with respect to materiality, and the Company has complied
with all agreements and satisfied all conditions on its part to be performed or satisfied hereunder
at or prior to the Closing Date, and (iii) there has not been, subsequent to the date of the most
recent quarterly unaudited financial statements included or incorporated by reference in the
Disclosure Package, any material adverse change in the financial position or results of operations
of the Company and its subsidiaries, taken as a whole, or any change or development that,
singularly or in the aggregate, would involve a material adverse change or a prospective material
adverse change, in or affecting the condition (financial or otherwise), results of operations,
business, assets or prospects of the Company and its subsidiaries taken as a whole, except as set
forth in the Prospectus.

               (f) Since the date of the latest audited financial statements included in the Disclosure
Package or incorporated by reference in the Disclosure Package as of the date hereof, (i) neither
the Company nor any of its subsidiaries shall have sustained any loss or interference with its
business from fire, explosion, flood or other calamity, whether or not covered by insurance, or
from any labor dispute or court or governmental action, order or decree, otherwise than as set
forth in the Disclosure Package, and (ii) there shall not have been any change in the capital stock
or long-term debt of the Company nor any of its subsidiaries, or any change, or any development
involving a prospective change, in or affecting the business, general affairs, management,
financial position, stockholders’ equity, results of operations or prospects of the Company and its
subsidiaries, taken as a whole, otherwise than as set forth in the Disclosure Package, the effect
of which, in any such case described in clause (i) or (ii) of this paragraph (f), is, in
the sole judgment of the Investor, so material and adverse as to make it impracticable or
inadvisable to proceed with the sale or delivery of the Units on the terms and in the manner
contemplated in the Disclosure Package.

               (g) No action shall have been taken and no law, statute, rule, regulation or order shall have
been enacted, adopted or issued by any governmental agency or body which would prevent the issuance
or sale of the Units or materially and adversely affect the business or operations of the Company
or its subsidiaries, taken as a whole; and no injunction, restraining order or order of any other
nature by any federal or state court of competent jurisdiction shall have been issued which would
prevent the issuance or sale of the Units or materially and adversely affect the business or
operations of the Company or its subsidiaries, taken as a whole.

               (h) Subsequent to the execution and delivery of this Agreement there shall not have occurred
any of the following: (i) trading in securities generally on the New York Stock Exchange, NASDAQ
Global Market or the American Stock Exchange or in the over-the-counter market, or trading in any
securities of the Company on any exchange or in the over-the-counter market, shall have been
suspended or materially limited, or minimum or maximum prices or maximum range for prices shall
have been established on any such exchange or such market by the Commission, by such exchange or
market or by any other regulatory body or governmental authority having jurisdiction, (ii) a
banking moratorium shall have been declared by Federal or state authorities or a material
disruption has occurred in commercial banking or securities settlement or clearance services in the
United States, (iii) the United States shall have become engaged in hostilities, or the subject of
an act of terrorism, or there shall have been an outbreak of or escalation in hostilities involving
the United States, or there shall have been a declaration of a national emergency or war by the
United States or (iv) there shall have occurred such a material adverse change in general economic,
political or

Annex I - 3 

 

financial conditions (or the effect of international conditions on the financial
markets in the United States shall be such) as to make it, in the sole judgment of the Investor,
impracticable or inadvisable to proceed with the sale or delivery of the Units on the terms and in
the manner contemplated in the Disclosure Package and the Prospectus.

               (i) The Investor shall have received the signed agreements, substantially in the form of
Exhibit C-1 hereto, of the persons listed on Exhibit C-2 hereto.

               (j) [The Other Investors shall purchase simultaneously with the Closing the Units that they
have agreed to purchase from the Company as described in Section 2.2.]5

All opinions, evidence and certificates mentioned above or elsewhere in this Agreement shall be
deemed to be in compliance with the provisions hereof only if they are in form and substance
reasonably satisfactory to counsel for the Investor.

          3.4 Delivery of Shares.

     Prior to the Closing, the Investor shall direct the broker-dealer at which the account or
accounts to be credited with the Shares being purchased by such Investor are maintained, which
broker/dealer shall be a DTC participant, to set up a DWAC instructing the Transfer Agent to credit
such account or accounts with the Shares. Such DWAC instruction shall indicate the settlement date
for the deposit of the Shares, which date shall be the Closing Date. Simultaneously with the
delivery to the Company of the funds on the Closing Date pursuant to Section 3.1 above, the
Company shall direct the Transfer Agent to credit the Investor’s account or accounts with the
Shares pursuant to the information contained in the DWAC.

     4. Representations and Warranties of the Company.

     The Company represents and warrants to the Investor that:

          4.1 The Registration Statement has become effective; no stop order suspending the
effectiveness of the Registration Statement is in effect, and no proceedings for such purpose are
pending before or, to the Company’s knowledge, after due inquiry, threatened by the Commission. If
the Registration Statement is an automatic shelf registration statement as defined in Rule 405
under the Act, the Company is a well-known seasoned issuer (as defined in Rule 405 under the Act)
eligible to use the Registration Statement as an automatic shelf registration statement and the
Company has not received notice that the Commission objects to the use of the Registration
Statement as an automatic shelf registration statement.

          4.2 (i) Each document, if any, filed or to be filed pursuant to the Exchange Act and
incorporated by reference in the Time of Sale Prospectus or the Prospectus complied or will comply
when so filed in all material respects with the Exchange Act and the applicable rules and
regulations of the Commission thereunder, (ii) each part of the Registration Statement, when such
part became effective, did not contain, and each such part, as amended or supplemented, if
applicable, will not contain any untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements therein not misleading,
(iii) the Registration Statement as of the date hereof does not contain any untrue statement of a
material fact or omit to state a material

 

			
	5	 	Note: Include this condition only for Venrock.

Annex I - 4 

 

fact required to be stated therein or necessary to make
the statements therein not misleading, (iv) the Registration Statement and the Prospectus comply,
and as amended or supplemented, if applicable, will comply in all material respects with the Act
and the applicable rules and regulations of the Commission thereunder, (v) the Time of Sale
Prospectus does not, and at the time of each sale of the Shares or the Warrants in connection with
the Offering when the Prospectus is not yet available to prospective purchasers and at the Closing
Date, the Time of Sale Prospectus, as then amended or supplemented by the Company, if applicable,
will not, contain any untrue statement of a material fact or omit to state a material fact
necessary to make the statements therein, in the light of the circumstances under which they were
made, not misleading, (vi) the Prospectus does not contain and, as amended or supplemented, if
applicable, will not contain any untrue statement of a material fact or omit to state a material
fact necessary to make the statements therein, in the light of the circumstances under which they
were made, not misleading and (vii) any free writing prospectus does not conflict with the
information contained in the Registration Statement, the Time of Sale Prospectus or the Prospectus,
except that the representations and warranties set forth in this paragraph do not apply to
statements or omissions in the Registration Statement, the Time of Sale Prospectus or the
Prospectus based upon information relating to any Investor furnished to the Company in writing by
such Investor expressly for use therein.

          4.3 The Company is not an “ineligible issuer” in connection with the Offering pursuant to
Rules 164, 405 and 433 under the Act. Any free writing prospectus that the Company is required to
file pursuant to Rule 433(d) under the Act has been, or will be, filed with the Commission in
accordance with the requirements of the Act and the applicable rules and regulations of the
Commission thereunder. Each free writing prospectus that the Company has filed, or is required to
file, pursuant to Rule 433(d) under the Act or that was prepared by or behalf of or used or
referred to by the Company complies or will comply in all material respects with the requirements
of the Act and the applicable rules and regulations of the Commission thereunder.

          4.4 The Company has been duly incorporated, is validly existing as a corporation in good
standing under the laws of the jurisdiction of its incorporation, has the corporate power and
authority to own its property and to conduct its business as described in the Time of Sale
Prospectus and Prospectus and is duly qualified to transact business and is in good standing in
each jurisdiction in which the conduct of its business or its ownership or leasing of property
requires such qualification, except to the extent that the failure to be so qualified or be in good
standing would not have a material adverse effect on the Company, including, without limitation, a
material adverse effect on the condition, financial or otherwise, or in the earnings, business or
operations of the Company or on the power or ability of the Company to perform its obligations
under this Agreement or to consummate the transactions contemplated by the Time of Sale Prospectus
(a “Material Adverse Effect”).

          4.5 There are no legal or governmental proceedings pending or, to the Company’s knowledge,
threatened to which the Company is a party or to which any of the properties of the Company is
subject other than proceedings accurately described in all material respects in the Time of Sale
Prospectus and proceedings that would not have a Material Adverse Effect.

          4.6 The Company has no subsidiaries.

          4.7 (a) This Agreement has been duly authorized, executed and delivered by the Company, and
(b) this Agreement constitutes a valid and binding obligation of the Company enforceable against
the Company in accordance with its terms, except as enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’

Annex I - 5 

 

and
contracting parties’ rights generally and except as enforceability may be subject to general
principles of equity (regardless of whether such enforceability is considered in a proceeding in
equity or at law) and except as to the enforceability of any rights to indemnification or
contribution that may be violative of the public policy underlying any law, rule or regulation
(including any federal or state securities law, rule or regulation).

          4.8 The authorized capital stock of the Company conforms in all material respects as to legal
matters to the description thereof contained in each of the Time of Sale Prospectus and the
Prospectus.

          4.9 The shares of Common Stock outstanding prior to the issuance of the Units have been duly
authorized and are validly issued, fully paid and non-assessable.

          4.10 The Shares to be issued and sold by the Company to the Investors hereunder and the
Warrant Shares have been duly and validly authorized, and the Shares, when issued and delivered
against payment therefor as provided herein, and the Warrant Shares, when issued and delivered
against payment therefore as provided in the Warrants, will be duly and validly issued, fully paid
and non-assessable and free of any preemptive or similar rights and will conform to the description
thereof contained in the Disclosure Package and the Prospectus.

          4.11 The execution and delivery by the Company of, and the performance by the Company of its
obligations under, this Agreement will not contravene any provision of (i) applicable law, (ii) the
amended and restated certificate of incorporation or bylaws of the Company, (iii) any agreement or
other instrument binding upon the Company, or (iv) any judgment, order or decree of any
governmental body, agency or court having jurisdiction over the Company except, in the cases of
clauses (i) and (iii) above for any such contravention that would not have a Material Adverse
Effect, and no consent, approval, authorization or order of, or qualification with, any
governmental body or agency is required for the performance by the Company of its obligations under
this Agreement, except such as may be required by the securities or Blue Sky laws of the various
states in connection with the offer and sale of the Shares.

          4.12 There has not occurred any material adverse change, or any development involving a
prospective material adverse change, in the condition, financial or otherwise, or in the earnings,
business or operations of the Company, from that set forth in the Time of Sale Prospectus.

          4.13 There are no legal or governmental proceedings pending or, to the Company’s knowledge,
threatened to which the Company is a party or to which any of the properties of the Company is
subject (i) other than proceedings accurately described in all material respects in the Time of
Sale Prospectus and proceedings that would not have a Material Adverse Effect or (ii) that are
required to be described in the Registration Statement or the Prospectus and are not so described;
and there are no statutes, regulations, contracts or other documents that are required to be
described in the Registration Statement or the Prospectus or to be filed as exhibits to the
Registration Statement that are not described or filed as required.

          4.14 Each preliminary prospectus filed pursuant to Rule 424 under the Act complied, and the
Prospectus and any amendments or supplements thereto shall comply when so filed, in all material
respects with the Act and the applicable rules and regulations of the Commission thereunder.

Annex I - 6 

 

          4.15 The Company is not, and after giving effect to the offering and sale of the Shares and
the application of the proceeds thereof as described in the Time of Sale Prospectus and the
Prospectus will not be, required to register as an “investment company” as such term is defined in
the Investment Company Act of 1940, as amended.

          4.16 The Company (i) is in compliance with any and all applicable foreign, federal, state and
local laws and regulations relating to the protection of human health and safety, the environment
or hazardous or toxic substances or wastes, pollutants or contaminants (“Environmental Laws”), (ii)
has received all permits, licenses or other approvals required under applicable Environmental Laws
to conduct its business and (iii) is in compliance with all terms and conditions of any such
permit, license or approval, except where such noncompliance with Environmental Laws, failure to
receive required permits, licenses or other approvals or failure to comply with the terms and
conditions of such permits, licenses or approvals would not, singly or in the aggregate, have a
Material Adverse Effect.

          4.17 There are no costs or liabilities associated with Environmental Laws (including, without
limitation, any capital or operating expenditures required for clean-up, closure of properties or
compliance with Environmental Laws or any permit, license or approval, any related constraints on
operating activities and any potential liabilities to third parties) that would, singly or in the
aggregate, have a Material Adverse Effect.

          4.18 Except as described in the Time of Sale Prospectus, there are no contracts, agreements or
understandings between the Company and any person granting such person the right to require the
Company to file a registration statement under the Act with respect to any securities of the
Company. There are no contracts, agreements or understandings between the Company and any person
granting such person the right to require the Company to include any securities in the registration
of the Shares as contemplated by this Agreement, the Time of Sale Prospectus and the Prospectus.

          4.19 Subsequent to the respective dates as of which information is given in each of the
Registration Statement, the Time of Sale Prospectus and the Prospectus, (i) the Company has not
incurred any material liability or obligation, direct or contingent, nor entered into any material
transaction not in the ordinary course of business; (ii) the Company has not purchased any of its
outstanding capital stock other than ordinary and customary repurchases of restricted stock from
employees upon termination of service pursuant to the terms of the Company’s equity incentive
plans, nor declared, paid or otherwise made any dividend or distribution of any kind on its capital
stock other than ordinary and customary dividends; and (iii) there has not been any material change
in the capital stock, short-term debt or long-term debt of the Company, except in each case as
described in each of the Registration Statement, the Time of Sale Prospectus and the Prospectus.

          4.20 The Company has good and marketable title to all personal property owned by it that is
material to the business of the Company, free and clear of all liens, encumbrances and defects
except as described in the Time of Sale Prospectus or such as do not materially affect the value of
such property and do not interfere with the use made and proposed to be made of such property by
the Company; and any real property and buildings held under lease by the Company is held under
valid, subsisting and enforceable leases with such exceptions as are not material and do not
interfere with the use made and proposed to be made of such property and buildings by the Company,
except as described in the Time of Sale Prospectus. The Company does not own any real property.

Annex I - 7 

 

          4.21 All patents and patent applications filed by or on behalf of the Company (the “Owned
Patents”) are owned or co-owned by the Company free and clear of all liens, encumbrances, defects
or other restrictions, except as would not, singly or in the aggregate, have a Material Adverse
Effect; and the Company is not aware of any valid or bona fide basis for a finding that any of the
Owned Patents in their entirety is unpatentable, invalid or unenforceable; and the Company
reasonably believes that the Owned Patents are patentable, valid and enforceable, except as would
not, singly or in the aggregate, have a Material Adverse Effect.

          4.22 In connection with the Company’s Owned Patents, all known relevant prior art references
were disclosed or will be disclosed to the USPTO to the extent required by and in accordance with
37 C.F.R. Section 1.56; all information submitted to the USPTO in such patent applications, and in
connection with the prosecution of such applications, was accurate in all material respects; and
neither the Company nor, to the Company’s knowledge, any other person made any material
misrepresentations or concealed any material information from the USPTO in such applications, or in
connection with the prosecution of such applications, in violation of 37 C.F.R. Section 1.56.

          4.23 Except as set forth in the Time of Sale Prospectus, the Company owns or possesses rights
to use, or can acquire on reasonable terms ownership of or rights to use, all patents, patent
applications, patent rights, licenses, inventions, copyrights, know-how (including trade secrets
and other unpatented and/or unpatentable proprietary or confidential information, systems or
procedures), trademarks, service marks, trade names and other intellectual property (collectively,
“Intellectual Property”) necessary for the conduct of the Company’s business as now conducted, and
for the manufacture, use or sale of its presently proposed products, as described in the Time of
Sale Prospectus, and the Company has not received any notice of infringement of or conflict with
asserted rights of others with respect to any of the foregoing that, singly or in the aggregate, if
the subject of an unfavorable decision, ruling or finding, would have a Material Adverse Effect.

          4.24 To the Company’s knowledge, after due inquiry, and except as would not have a Material
Adverse Effect, there are no valid and enforceable rights of third parties to such Intellectual
Property that are or would be infringed by the business currently conducted by the Company or in
the manufacture, use, sale, offer for sale or import of its presently proposed products, as
described in the Time of Sale Prospectus.

          4.25 The Company is not subject to any judgment, order, writ, injunction or decree of any
court or any federal, state, local, foreign or other governmental department, commission, board,
bureau, agency or instrumentality, domestic or foreign, or any arbitrator. Except as would not have
a Material Adverse Effect, the Company is not a party to any contract, which restricts or impairs
its use of any Intellectual Property.

          4.26 To the Company’s knowledge, after due inquiry, there are no ongoing infringements by
others of any Intellectual Property owned by the Company in connection with the business currently
conducted by the Company or its presently proposed products, as described in the Prospectus.

          4.27 Other than as disclosed in the Time of Sale Prospectus and except as would not have a
Material Adverse Effect, to the Company’s knowledge, after due inquiry, there is no U.S. patent or
published U.S. patent application which contains valid and enforceable claims that dominate or that

Annex I - 8 

 

would dominate any Owned Patent or other Intellectual Property owned by the Company or that
interferes with the issued or pending claims of any such Owned Patent or other Intellectual
Property.

          4.28 No material labor dispute with the employees of the Company exists or, to the knowledge
of the Company, is imminent; and the Company is not aware of any existing, threatened or imminent
labor disturbance by the employees of any of its principal suppliers, manufacturers or contractors
that would reasonably be expected to have a Material Adverse Effect.

          4.29 The Company is insured by insurers of recognized financial responsibility against such
losses and risks and in such amounts as are prudent and customary in the businesses in which it is
engaged; the Company has not been refused any insurance coverage previously held in the last year
or customarily carried in the business in which it is engaged; and the Company has no reason to
believe that it will not be able to renew its existing insurance coverage as and when such coverage
expires or to obtain similar coverage from similar insurers as may be necessary to continue its
business at a cost that would not have a Material Adverse Effect, except as described in the Time
of Sale Prospectus.

          4.30 Except as described in the Time of Sale Prospectus, the Company has not sold, issued or
distributed any shares of Common Stock during the six-month period preceding the date hereof,
including any sales pursuant to Rule 144A under, or Regulation D or S of, the Act, other than
shares issued pursuant to employee benefit plans, qualified stock option plans or other employee
compensation plans or arrangements, or pursuant to outstanding options, restricted stock units,
rights or warrants.

          4.31 The Company has established and maintains disclosure controls and procedures (as defined
in Rule 13a-15 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)). Such
disclosure controls and procedures are designed to ensure that information required to be disclosed
by the Company is recorded, processed, summarized and reported, within the time periods specified
in the Commission’s rules and forms and that such information is accumulated and communicated to
the Company’s principal executive officer and its principal financial officer. Such disclosure
controls and procedures are sufficient to provide reasonable assurance that the Company’s principal
executive officer and principal financial officer are alerted to material information required to
be included in the Company’s periodic reports required under the Exchange Act so as to allow timely
decisions regarding required disclosure.

          4.32 The Company maintains a system of internal control over financial reporting (as defined
in Rule 13a-15 under the Exchange Act) sufficient to provide reasonable assurance that (i)
transactions are executed in accordance with management’s general or specific authorizations; (ii)
transactions are recorded as necessary to permit preparation of financial statements in accordance
with generally accepted accounting principles and to maintain asset accountability; (iii) access to
assets is permitted only in accordance with management’s general or specific authorization; and
(iv) the recorded accountability for assets is compared with the existing assets at reasonable
intervals and appropriate action is taken with respect to any differences.

          4.33 There are no outstanding loans made by the Company to any executive officer (as defined
in Rule 3b-7 under the Exchange Act) or director of the Company which are prohibited by Section 402
of the Sarbanes-Oxley Act of 2002, as amended. The Company has not since January 19, 2005 taken
any action prohibited by Section 402 of the Sarbanes-Oxley Act of 2002, as amended.

Annex I - 9 

 

          4.34 The Company has all necessary consents, authorizations, approvals, orders, certificates
and permits of and from, and has made all required declarations and filings with, and complied with
all formal recommendations of, all federal, state, local and other governmental authorities, all
self-regulatory organizations and all courts and other tribunals, to own, lease, license and use
its properties and assets and to conduct its business in the manner described in the Time of Sale
Prospectus, including, without limitation, all necessary U.S. Food and Drug Administration (“FDA”),
independent data monitoring committee, and applicable foreign regulatory agency approvals and
recommendations, except as disclosed in the Time of Sale Prospectus, and except to the extent that
the failure to obtain such consents, authorizations, approvals, orders, certificates, permits, or
to make such declarations or filings, or to follow such recommendations would not have a Material
Adverse Effect. The Company has not received any notice of proceedings relating to the revocation
or modification of any such consent, authorization, approval, order, certificate, permit or
recommendation which, singly or in the aggregate, if the subject of an unfavorable decision, ruling
or finding, would have a Material Adverse Effect, except as described in the Time of Sale
Prospectus.

          4.35 No investigational new drug (“IND”) application filed by or on behalf of the Company with
the FDA has been terminated by the FDA, and none of the FDA, any independent data monitoring
committee, or any applicable foreign regulatory agency has recommended, commenced, or, to the
knowledge of the Company, threatened to initiate, any action to place a clinical hold order on, or
otherwise delay or suspend, proposed or ongoing clinical investigations conducted or proposed to be
conducted by or on behalf of the Company.

          4.36 To the best of the Company’s knowledge, all the operations of the Company and all the
manufacturing facilities and operations of the Company’s suppliers of products and product
candidates and the components thereof manufactured in or imported into the United States are in
compliance with applicable FDA regulations, including current Good Manufacturing Practices, and
meet sanitation standards set by the Federal Food, Drug and Cosmetic Act of 1938, as amended, and
all the operations of the Company and all the manufacturing facilities and operations of the
Company’s suppliers of products and product candidates manufactured outside, or exported from, the
United States are in compliance with applicable foreign regulatory requirements and standards,
except to the extent that the failure to be in compliance with such regulations and standards would
not have a Material Adverse Effect.

          4.37 Except as described in the Time of Sale Prospectus, the clinical trials and the human and
animal studies that are described in the Time of Sale Prospectus were and, if still pending, are
being, conducted (to the knowledge of the Company with respect to such studies conducted by or on
behalf of third parties) in accordance in all material respects with standard medical and
scientific research procedures and all applicable rules, regulations and policies of the FDA,
including the current Good Clinical Practices and Good Laboratory Practices, and all applicable
foreign regulatory requirements and standards.

          4.38 The Company has operated its business and currently is in compliance in all material
respects with all applicable rules, regulations and policies of the FDA and any applicable foreign
regulatory organization and all recommendations and actions of any independent data monitoring
committee.

          4.39 The Shares and Warrant Shares will be listed at or prior to Closing on the NASDAQ Global
Market, subject only to official notice of issuance.

Annex I - 10 

 

     5. Covenants of the Company.

          5.1 The Company hereby agrees that, without the prior written consent of the Investor, it will
not, during the period (the “Lock-Up Period”) ending 90 days after the date of the Prospectus,
(i) offer, pledge, sell, contract to sell, sell any option or contract to purchase, purchase any
option or contract to sell, grant any option, right or warrant to purchase, lend, or otherwise
transfer or dispose of, directly or indirectly, any shares of Common Stock or any securities
convertible into or exercisable or exchangeable for Common Stock; (ii) file any registration
statement with the Commission relating to the offering of any shares of Common Stock or any
securities convertible into or exercisable or exchangeable for Common Stock; or (iii) enter into
any swap or other arrangement that transfers to another, in whole or in part, any of the economic
consequences of ownership of the Common Stock, whether any such transaction described in
clause (i), (ii) or (iii) above is to be settled by delivery of Common Stock or such other
securities, in cash or otherwise. The foregoing sentence shall not apply to (A) the Shares,
Warrants, or Warrant Shares to be sold hereunder, (B) the issuance by the Company of shares of
Common Stock upon the exercise of an option or warrant, the vesting or settlement of any restricted
stock units or other equity compensation awards or the conversion of a security, in each case
outstanding on the date hereof; (C) the grant of options, restricted stock units or other equity
compensation awards, or the issuance of shares of Common Stock by the Company to employees,
officers, directors, advisors or consultants of the Company in each case either (x) pursuant to
equity incentive and employee stock purchase plans described in the Prospectus or (y) as an
inducement grant within the meaning of NASDAQ Rule 4350(i)(1)(iv) consistent with past practice,
and the issuance by the Company of any shares of Common Stock upon the exercise, vesting or
settlement of such equity compensation awards; or (D) the filing of any registration statement (x)
on Form S-8 in respect of any equity compensation plans or arrangements maintained by the Company,
(y) that the Company is contractually obligated to file pursuant to the terms of that certain Fifth
Amended and Restated Investors Rights Agreement, dated December 16, 2004, by and among the Company
and certain stockholders of the Company or (z) that the Company files pursuant to Section 5.3
hereof.

          5.2 Promptly following the Closing, the Company shall reimburse the Investor for the
reasonable and documented fees and expenses incurred in connection with the transactions
contemplated by this Agreement, including the expenses of counsel to the Investor (which fees shall
include, without limitation, the fees and expenses associated with the negotiation, preparation and
execution and delivery of this Agreement and the other transaction documents), up to a maximum of
$75,000 for each of the Investors associated with [name of fund] and the Other Investors associated
with [name of fund]. The Company and the Investor shall otherwise each pay the fees and expenses
of their respective advisers, counsel, accountants and other experts, if any, and all other
expenses incurred by such party in connection with the negotiation, preparation, execution,
delivery and performance of this Agreement. The Company shall pay all Transfer Agent fees, stamp
taxes and other taxes and duties levied in connection with the sale and issuance of the Units to
the Investor and issuance of the Warrant Shares.

          5.3

               (a) If all or any portion of a Warrant is exercised at a time when there is an effective
registration statement to cover the issuance of the Warrant Shares or if the Warrant is exercised
via cashless exercise more than twelve months after the issuance thereof at a time at which the
Investor is not an Affiliate of the Company, the Warrant Shares issued pursuant to any such
exercise shall be issued free of all legends.

Annex I - 11 

 

               (b) Subject to Section 5.3(d), the Company shall use reasonable efforts to keep a registration
statement (including the Registration Statement) registering the issuance of the Warrant Shares
effective and available until the earlier of the first anniversary of the Closing or such time as
all Warrant Shares have been issued.

               (c) Subject to Section 5.3(d), if all Warrant Shares have not been issued on or prior to the
first anniversary of the Closing, following a written request by the Investor on not more than
three (3) occasions during any twelve month period, the Company shall use reasonable efforts to
cause a registration statement (including the Registration Statement) registering the issuance of
the Warrant Shares to be effective and available within ten (10) Trading Days after such notice and
to keep such registration statement effective and available until the earlier of twenty (20)
Trading Days after such effectiveness and availability or such time as all Warrant Shares held by
the Investor have been issued.

               (d) If following the date hereof the Registration Statement (or any subsequent registration
statement registering the Warrant Shares) is not effective or is not otherwise available for the
sale of the Warrant Shares during a period in which a registration statement is required to be
effective and available pursuant to Section 5.3(b) or Section 5.3(c) (a “Registration Event”), (i)
the Company shall promptly notify the holders of the Warrants in writing that such registration
statement is not then effective or available and thereafter shall promptly notify such holders when
a registration statement is effective again and available for the sale of the Warrant Shares and
(ii) to the extent that there are Registration Events occurring (x) on more than an aggregate of
sixty (60) days in the period required by Section 5.3(b) or (y) on more than an aggregate of five
(5) Trading Days in each period required by Section 5.3(c), the Company will make payments to the
Investor, as liquidated damages and not as a penalty, in an amount equal to 1.0% of Fair Market
Value (as defined in the Warrants and as determined on the last business day for each 30-day period
(or pro rata for any portion thereof) for which such payment is due) multiplied by the number of
Warrant Shares held by the Investor for each 30-day period (or pro rata for any portion thereof)
following any Registration Events occurring on more than the time periods specified in clause (ii)
above. The amounts payable as liquidated damages pursuant to the preceding sentence shall be paid
monthly within five (5) Trading Days of the last day of each 30-day period (or pro rata for any
portion thereof) following any Registration Events occurring on more than the time periods
specified in clause (ii) above. Such payments shall constitute the Investor’s exclusive monetary
remedy for such events, but shall not affect the right of the Investor to seek injunctive relief.
Such payments shall be made to the Investor in cash. The twenty (20) Trading Day period specified
in Section 5.3(c) shall be extended by the number of Trading Days on which there are Registration
Events during such twenty (20) Trading Day period.

               (e) For purposes of this Section 5.3, the term “Trading Day” shall have the meaning ascribed to
such term in the Warrants.

     6. Representations, Warranties and Covenants of the Investor.

     The Investor acknowledges, represents and warrants to, and agrees with, the Company that:

          6.1 The Investor (a) is knowledgeable, sophisticated and experienced in making, and is
qualified to make decisions with respect to, investments in securities presenting an investment
decision like that involved in the purchase of the Units, including investments in securities
issued by the Company and investments in comparable companies, (b) has answered all questions on
the Signature Page and the Investor Questionnaire and the answers thereto are true and correct as
of the

Annex I - 12 

 

date hereof and will be true and correct as of the Closing Date and (c) in connection with
its decision to purchase the number of Units set forth on the Signature Page, has received and is
relying only upon the Disclosure Package (including the documents incorporated by reference
therein).

          6.2 (a) No action has been or will be taken in any jurisdiction outside the United States by
the Company that would permit an offering of the Units, or possession or distribution of offering
materials in connection with the issue of the Securities in any jurisdiction outside the United
States where action for that purpose is required, (b) if the Investor is outside the United States,
it will comply with all applicable laws and regulations in each foreign jurisdiction in which it
purchases, offers, sells or delivers Securities or has in its possession or distributes any
offering material, in all cases at its own expense and (c) no agent of the Company has been
authorized to make and no such agent has made any representation, disclosure or use of any
information in connection with the issue, placement, purchase and sale of the Units, except as set
forth in the Issuer Free Writing Prospectus or as set forth in or incorporated by reference in the
Base Prospectus or the Prospectus Supplement or as otherwise contemplated by this Agreement.

          6.3 (a) The Investor has full right, power, authority and capacity to enter into this
Agreement and to consummate the transactions contemplated hereby and has taken all necessary action
to authorize the execution, delivery and performance of this Agreement, and (b) this Agreement
constitutes a valid and binding obligation of the Investor enforceable against the Investor in
accordance with its terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting creditors’ and contracting
parties’ rights generally and except as enforceability may be subject to general principles of
equity (regardless of whether such enforceability is considered in a proceeding in equity or at
law) and except as to the enforceability of any rights to indemnification or contribution that may
be violative of the public policy underlying any law, rule or regulation (including any federal or
state securities law, rule or regulation).

          6.4 The Investor understands that nothing in this Agreement, the Prospectus, the Disclosure
Package or any other materials presented to the Investor in connection with the purchase and sale
of the Units constitutes legal, tax or investment advice. The Investor has consulted such legal,
tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in
connection with its purchase of Units. The Investor also understands that there is no established
public trading market for the Warrants being offered in the Offering, and that the Company does not
expect such a market to develop. In addition, the Company does not intend to apply for listing the
Warrants on any securities exchange. Without an active market, the liquidity of the Warrants will
be limited.

          6.5 Since the date on which the Company first contacted such Investor about the Offering or
such Investor first learned of the Offering from its investment manager, whichever occurred first,
the Investor has not engaged in any transactions in the securities of the Company (including,
without limitation, any Short Sales involving the Company’s securities). Each Investor covenants
that it will not engage in any transactions in the securities of the Company (including Short
Sales) or disclose any information about the Offering (other than to its advisors that are under a
legal obligation of confidentiality) prior to the later of (a) the time that the transactions
contemplated by this Agreement are publicly disclosed and (b) the open of regular trading on The
NASDAQ Global Market on December 30, 2008. Each Investor agrees that it will not use any of the
Securities acquired pursuant to this Agreement to cover any short position in the Common Stock if
doing so would be in violation of applicable securities laws. For purposes hereof, “Short Sales”
include, without limitation, all “short sales” as defined in Rule 200 promulgated under Regulation
SHO under the Exchange Act, whether or not against the box, and all types of direct and indirect
stock pledges, forward sales contracts, options,

Annex I - 13 

 

puts, calls, short sales, swaps, “put equivalent
positions” (as defined in Rule 16a-1(h) under the Exchange Act) and similar arrangements (including
on a total return basis), and sales and other transactions through non-US broker dealers or foreign
regulated brokers.

     7. Termination of Representations, Warranties and Agreements. All covenants, agreements,
representations and warranties made by the Company and the Investor herein will terminate upon the
delivery to the Investor of the Units being purchased and the payment therefor, other than the
covenants and agreements set forth in Section 5 hereof.

     8. Notices. All notices, requests, consents and other communications hereunder will be in
writing, will be mailed (a) if within the domestic United States by first-class registered or
certified airmail, or nationally recognized overnight express courier, postage prepaid, or by
facsimile or (b) if delivered from outside the United States, by International Federal Express or
facsimile, and will be deemed given (i) if delivered by first-class registered or certified mail
domestic, three business days after so mailed, (ii) if delivered by nationally recognized overnight
carrier, one business day after so mailed, (iii) if delivered by International Federal Express, two
business days after so mailed and (iv) if delivered by facsimile, upon electric confirmation of
receipt and will be delivered and addressed as follows:

               (a) if to the Company, to:

XenoPort, Inc.

3410 Central Expressway

Santa Clara, California 95051

Attention: Gianna Bosko, Vice President and General Counsel

Facsimile: (408) 616-7214

with copies to (which shall not constitute notice):

Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306

Attention: Suzanne Sawochka Hooper, Esq.

Facsimile: (650) 849-7400

               (b) if to the Investor, at its address on the Signature Page hereto, or at such other address
or addresses as may be furnished to the Company in writing by the Investor.

     9. Changes. This Agreement may not be modified or amended except pursuant to an instrument
in writing signed by the Company and the Investor.

     10. Headings. The headings of the various sections of this Agreement have been inserted for
convenience of reference only and will not be deemed to be part of this Agreement.

     11. Severability. In case any provision contained in this Agreement should be invalid,
illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining
provisions contained herein will not in any way be affected or impaired thereby.

Annex I - 14 

 

     12. Governing Law. This Agreement will be governed by, and construed in accordance with, the
internal laws of the State of California, without giving effect to the principles of conflicts of
law that would require the application of the laws of any other jurisdiction.

     13. Counterparts. This Agreement may be executed in two or more counterparts, each of which
will constitute an original, but all of which, when taken together, will constitute but one
instrument, and will become effective when one or more counterparts have been signed by each party
hereto and delivered to the other parties. The Company and the Investor acknowledge and agree that
the Company shall deliver its counterpart to the Investor.

     14. Confirmation of Sale. The Investor acknowledges and agrees that such Investor’s receipt
of the Company’s counterpart to this Agreement, shall constitute written confirmation of the
Company’s acceptance and agreement to sale the applicable Units to such Investor.

     15. Press Release. The Company and the Investor agree that the Company shall issue a press
release announcing the Offering prior to the open of regular trading on The NASDAQ Global Market on
December 30, 2008 and shall file the related Form 8-K on December 30, 2008.

     16. Termination. In the event that the Closing shall not have occurred within ten business
days from the date of this Agreement due to the Company’s or the Investor’s failure to satisfy the
conditions set forth in Sections 3.2 and 3.3 above (and the non-breaching party’s failure to waive
such unsatisfied condition(s)), the non-breaching party shall have the option to terminate this
Agreement with respect to such breaching party at the close of business on such date.

Annex I - 15 

 

Exhibit A

XENOPORT, INC.

INVESTOR QUESTIONNAIRE

     Pursuant to Section 3 of Annex I to the Agreement, please provide us with the
following information:

	 	 	 	 	 
	1.

	 	The exact name that your Shares and Warrants are to be registered
in. You may use a nominee name if appropriate:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	2.

	 	The relationship between the Investor and the registered holder
listed in response to item 1 above:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	3.

	 	The mailing address of the registered holder listed in response to
item 1 above:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	4.

	 	The Social Security Number or Tax Identification Number of the
registered holder listed in the response to item 1 above:	 	 
	 
	 	 	 	 
	5.

	 	Name of DTC Participant (broker-dealer at which the account or
accounts to be credited with the Shares are maintained):	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	6.

	 	DTC Participant Number:	 	 
	 
	 	 	 	 
	7.

	 	Name of Account at DTC Participant being credited with the Shares:	 	 
	 
	 	 	 	 
	8.

	 	Account Number at DTC Participant being credited with the Shares:	 	 
	 

	 	 	 	 

A - 1 

 

EXHIBIT B

Form of Warrant

B-1 

 

EXHIBIT C-1

Form of Lock-Up Agreement

___, 200_

[INVESTORS]

Ladies and Gentlemen:

     The undersigned understands that the recipients hereof (collectively, the “Investors”) propose
to enter into Purchase Agreements (the “Purchase Agreements”) with XenoPort, Inc., a Delaware
corporation (the “Company”), providing for the public offering (the “Public Offering”) by the
Company of shares (the “Shares”) of the Common Stock (par value $0.001 per share) of the Company
(the “Common Stock”) and warrants to purchase shares of Common Stock (the “Warrants”) to the
Investors.

     To induce the Investors to enter into the Purchase Agreements, the undersigned hereby agrees
that, without the prior written consent of each of the Investors, it will not, during the period
(the “Lock-Up Period”) commencing on the date hereof and ending 90 days after the date of the final
prospectus supplement relating to the Public Offering (the “Prospectus”), (1) offer, pledge, sell,
contract to sell, sell any option or contract to purchase, purchase any option or contract to sell,
grant any option, right or warrant to purchase, lend, or otherwise transfer or dispose of, directly
or indirectly, any shares of Common Stock or any securities convertible into or exercisable or
exchangeable for Common Stock or (2) enter into any swap or other arrangement that transfers to
another, in whole or in part, any of the economic consequences of ownership of the Common Stock,
whether any such transaction described in clause (1) or (2) above is to be settled by delivery of
Common Stock or such other securities, in cash or otherwise. The foregoing sentence shall not
apply to transactions relating to shares of Common Stock or other securities acquired in open
market transactions after the completion of the Public Offering; provided that no filing by any
party under Section 16(a) of the Securities Exchange Act of 1934, as amended (the “Exchange Act”),
shall be required or shall be voluntarily made in connection with subsequent sales of Common Stock
or other securities acquired in such open market transactions. In addition, the undersigned agrees
that, without the prior written consent of each of the Investors, it will not, during the Lock-Up
Period, make any demand for or exercise any right with respect to, the registration of any shares
of Common Stock or any security convertible into or exercisable or exchangeable for Common Stock.
The undersigned also agrees and consents to the entry of stop transfer instructions with the
Company’s transfer agent and registrar against the transfer of the undersigned’s shares of Common
Stock except in compliance with the foregoing restrictions.

     Notwithstanding the foregoing, (1) if the undersigned is an individual, the undersigned may
transfer shares of Common Stock or securities convertible into or exchangeable or exercisable for
Common Stock by gift or gifts, will or intestacy to a member or members of his or her immediate
family, to a trust formed for the benefit of any such person, or to a partnership, the partners of
which are exclusively the undersigned and/or a member or members of his or her immediate family
and/or a charity; (2) if the undersigned is a partnership, trust, corporation or similar entity,
the undersigned may transfer or distribute shares of Common Stock or securities convertible into or
exchangeable or exercisable for Common Stock to its partners, limited liability company members or
stockholders; (3) the undersigned may sell shares of Common Stock pursuant to an existing 10b5-1
plan which is

C-1 

 

disclosed to each of the Investors prior to the date hereof; (4) the undersigned may
enter into a 10b5-1 plan during the Lock-Up Period if sales under such plan do not occur until
after the expiration of the Lock-Up Period; (5) the undersigned may “net” exercise outstanding
options or warrants to purchase Common Stock in accordance with their terms; (6) the undersigned
may transfer shares of Common Stock to the Company to satisfy tax withholding obligations pursuant
to Company equity compensation plans or arrangements; and (7) the undersigned may transfer shares
of Common Stock or securities convertible into or exchangeable or exercisable for Common Stock
pursuant to a sale or an offer to purchase 100% of the outstanding Common Stock, whether pursuant
to a merger, tender offer or otherwise, to a third party or group of third parties; provided,
however, that in each of (1) and (2) above, it shall be a condition to the transfer or distribution
that (i) the transferee execute a copy of this Lock-Up Agreement, (ii) no filing by any party
(donor, donee, transferor or transferee) under Section 16(a) of the Exchange Act shall be required
or shall be made voluntarily in connection with such transfer or distribution (other than a filing
on Form 5 made after the expiration of the Lock-Up Period), and (iii) no such transfer or
distribution may include a disposition for value; and provided further that any Common Stock
acquired upon the net exercise of options or warrants described in clause (5) above shall be
subject to the restrictions imposed by this Lock-Up Agreement. For purposes of this paragraph,
“immediate family” means the spouse, domestic partner, lineal descendants, father, mother, brother
or sister of the transferor.

     The undersigned understands that the Company and each of the Investors are relying upon this
agreement in proceeding toward consummation of the Public Offering. The undersigned further
understands that this agreement is irrevocable and shall be binding upon the undersigned’s heirs,
legal representatives, successors and assigns.

     Whether or not the Public Offering actually occurs depends on a number of factors, including
market conditions. Any Public Offering will only be made pursuant to Purchase Agreements, the
terms of which are subject to negotiation between the Company and the Investors.

     This Lock-Up Agreement shall lapse and become null and void if (a) no shares have been
purchased and paid for pursuant to the Purchase Agreements by January 31, 2009 or (b) the Company
notifies the Investors in writing that it does not intend to proceed with the Public Offering.

	 	 	 	 	 
	 

	 	Very truly yours,
	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 

	 	(Name)	 	 
	 
	 	 	 	 
	 

	 	 	 	 
	 

	 	(Address)	 	 

C-1 

 

EXHIBIT C-2

Parties to Lock-Up Agreement

Vincent Angotti

Ronald Barrett

Paul Berns

Kenneth Cundy

John Freund

Catherine Friedman

Mark Gallop

William Harris

Jeryl Hilleman 

Per Lofberg

Kenneth Nussbacher

William Rieflin

David Savello

David Stamler

Gary Tollefson

Wendell Wierenga

C-2

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