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                                                                   EXHIBIT 10.16

                            ALLOS THERAPEUTICS, INC.
                            EMPLOYMENT AGREEMENT FOR
                                 MICHAEL E. HART

THIS EMPLOYMENT AGREEMENT (the "Agreement") is made as of this 17th day of
December, 2001, by and between ALLOS THERAPEUTICS, INC., (the "Company"), and
MICHAEL E. HART ("Executive") (collectively, the "Parties").

WHEREAS, Executive is critical to the ongoing operation of the Company and the
commercialization of the Company's products; and

WHEREAS, the Company wishes to continue to employ Executive and to assure itself
of the continued services of Executive in his new assignment as President and
Chief Executive Officer, on the terms set forth herein;

WHEREAS, Executive is currently serving the Company under the terms of that
certain Employment Agreement, dated January 17, 2001, by and between the
Executive and the Company (the "Prior Agreement"); and

WHEREAS, Executive and the Company desire to terminate the Prior Agreement and
Executive wishes to be so employed under the terms set forth herein.

NOW, THEREFORE, in consideration of the promises, mutual covenants, the above
recitals, and the agreements herein set forth, and for other good and valuable
consideration, the sufficiency of which is hereby acknowledged, the Parties
agree to the following terms and conditions of the Executive's employment:

1. EMPLOYMENT. The Company hereby agrees to employ Executive as President and
Chief Executive Officer and Executive hereby accepts such employment upon the
terms and conditions set forth herein as of the date first written above.

2. TERMINATION OF PRIOR AGREEMENT. Executive and the Company hereby agree to
terminate the Prior Agreement in its entirety pursuant to Section 14(b) thereof.

3. AT-WILL EMPLOYMENT. It is understood and agreed by the Company and Executive
that this Agreement does not contain any promise or representation concerning
the duration of Executive's employment with the Company. Executive specifically
acknowledges that his employment with the Company is at-will and may be altered
or terminated by either Executive or the Company at any time, with or without
cause and/or with or without notice. The nature, terms or conditions of
Executive's employment with the Company cannot be changed by any oral
representation, custom, habit or practice, or any other writing. In addition,
that the rate of salary, any bonuses, paid time off, other compensation, or
vesting schedules are stated in units of years or months does not alter the
at-will nature of the employment, and does not mean and should not be
interpreted to mean that Executive is guaranteed employment to the end of any
period of time or for any period of time. In the event of conflict between this
disclaimer and any other statement, oral or written, present or future,
concerning terms and conditions of employment, the at-will relationship
confirmed by this disclaimer shall control. This at-will status cannot be
altered except in writing signed by Executive and the Chairman of the Board of
Directors.

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4. DUTIES. Executive shall render full-time services to the Company as its
President and Chief Executive Officer. Executive shall devote his best efforts
and his full business time, skill and attention to the performance of his duties
on behalf of the Company.

5. POLICIES AND PROCEDURES. Executive agrees that he is subject to and will
comply with the policies and procedures of the Company, as such policies and
procedures may be modified, added to or eliminated from time to time at the sole
discretion of the Company, except to the extent any such policy or procedure
specifically conflicts with the express terms of this Agreement. Executive
further agrees and acknowledges that any written or oral policies and procedures
of the Company do not constitute contracts between the Company and Executive.

6. COMPENSATION. For all services rendered and to be rendered hereunder, the
Company agrees to pay to the Executive, and the Executive agrees to accept a
base salary of $300,000 per annum. Any such salary shall be payable in equal
biweekly installments and shall be subject to such deductions or withholdings as
the Company is required to make pursuant to law, or by further agreement with
the Executive. The Board of Directors may adjust the Executive's compensation
from time to time in its sole and complete discretion.

7. BONUS. Executive will be eligible for a discretionary bonus in an amount
equal to 35 % of Executive's base salary ("Bonus"). The decision to award the
Bonus and/or to modify the amount of any bonus given is within the sole and
complete discretion of the Board.

8. STOCK OPTIONS.

         (a) The Executive will receive an option to purchase 100,000 shares of
         the Company's Common Stock under the Company's 2000 Equity Incentive
         Plan (the "Plan") at an exercise price equal to the closing sale price
         of the Company's Common Stock as reported on the Nasdaq National Market
         on the date approved by the Compensation Committee of the Board of
         Directors. Such option will be subject to the terms and conditions of
         the Plan and will vest in accordance with the Company's standard
         vesting schedule.

         (b) If and when the Company's 2001 Broad Based Equity Incentive Plan
         (the "Broad Based Plan") is adopted by the Board of Directors, the
         Executive will receive an option to purchase 250,000 shares of the
         Company's Common Stock under the Broad Based Plan at an exercise price
         equal to the then current fair market value of the Company's Common
         Stock as reported on the Nasdaq National Market. Such option will be
         subject to terms and conditions of the Broad Based Plan and will vest
         in accordance with the Company's standard vesting schedule.

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(c) If the Broad Based Plan is not adopted by the Board of Directors, then at
the next annual meeting of the Company's stockholders the Company shall seek
approval from the Company's stockholders for an increase in the number of shares
reserved under the plan of at least 250,000 shares; upon such approval, the
Company shall grant Executive an option to purchase 250,000 shares of the
Company's Common Stock under the Plan with an exercise price equal to the then
current fair market value as reported on the NASDAQ National Market and such
option shall vest in accordance with the Company's standard vesting schedule,
provided however, that the Vesting Commencement Date for such option shall be
the date hereof;

(d) If the Broad Based Plan is not adopted by the Board of the Directors and the
stockholders of the Company do not approve an increase in the Plan as set forth
in Section 8(c) hereof, the Executive will be entitled to receive (i) two (2)
additional grants under the Plan of 125,000 shares of the Company's Common Stock
each to occur on December 17, 2002 and December 17, 2003 with exercise
prices equal to the then current fair market values as reported on the NASDAQ
National Market on such dates and such options shall vest in accordance with the
Company's standard vesting schedule, provided however, that the Vesting
Commencement Date of each such option shall be the date hereof; or (ii) such
other alternative compensation that the Executive and the Company may agree
upon.

9. OTHER BENEFITS. While employed by the Company as provided herein:

         (a) Executive and Employee Benefits. The Executive shall be entitled to
         all benefits to which other executive officers of the Company are
         entitled, on terms comparable thereto, including, without limitation,
         participation in the 401(k) plan, group insurance policies and plans,
         medical, health, vision, and disability insurance policies and plans,
         and the like, which may be maintained by the Company for the benefit of
         its executives. The Company reserves the right to alter and amend the
         benefits received by Executive from time to time at the Company's
         discretion.

         (b) Additional Insurance. Subject to such insurance being available
         under the Company's plans, the Executive shall be entitled to and the
         Company shall pay for additional term life insurance up to a maximum of
         $3,000,000 (the beneficiary of which will be the Executive's immediate
         family directly or through a trust) and additional supplemental
         disability insurance up to the maximum available under the Company's
         plans.

         (c) Expense Reimbursement. The Executive shall receive, against
         presentation of proper receipts and vouchers, reimbursement for direct
         and reasonable out-of-pocket expenses incurred by him in connection
         with the performance of his duties hereunder, according to the policies
         of the Company.

         (d) Personal Time Off. The Executive shall be entitled to personal time
         off and sick leave according to the Company's benefits package.

         10. PROPRIETARY AND OTHER OBLIGATIONS. Executive agrees to continue to
         abide by Executive's previously executed Non-Competition, Proprietary
         Information and Inventions Agreement attached hereto as Exhibit A.

         11. TERMINATION. Executive and the Company each acknowledge that either
         party has the right to terminate Executive's employment with the
         Company at any time for any reason whatsoever, with or without cause or
         advance notice pursuant to the following:

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         (a) Termination by Death or Disability. Subject to applicable state or
         federal law, in the event Executive shall die during the period of his
         employment hereunder or become permanently disabled, as evidenced by
         notice to the Company and Executive's inability to carry out his job
         responsibilities for a continuous period of more than three months,
         Executive's employment and the Company's obligation to make payments
         hereunder shall terminate on the date of his death, or the date upon
         which, in the sole determination of the Board of Directors, Executive
         has failed to carry out his job responsibilities for three months
         except the Company shall pay the Executive's estate any salary earned
         but unpaid prior to termination, all accrued but unused personal time
         and any business expenses that were incurred but not reimbursed as of
         the date of termination. Vesting of any unvested stock options shall
         cease on the date of termination.

         (b) Voluntary Resignation by Executive. In the event the Executive
         voluntarily terminates his employment with the Company (other than for
         Good Reason as defined below), the Company's obligation to make
         payments hereunder shall cease upon such termination, except the
         Company shall pay Executive any salary earned but unpaid prior to
         termination, all accrued but unused personal time and any business
         expenses that were incurred but not reimbursed as of the date of
         termination. Vesting of any unvested stock options shall cease on the
         date of termination.

         (c) Termination for Just Cause. In the event the Executive is
         terminated by the Company for Just Cause (as defined below), the
         Company's obligation to make payments hereunder shall cease upon the
         date of receipt by Executive of written notice of such termination (the
         "date of termination" for purposes of this paragraph 9(c)), except the
         Company shall pay Executive any salary earned but unpaid prior to
         termination, all accrued but unused personal time and any business
         expenses that were incurred but not reimbursed as of the date of
         termination. Vesting of any unvested stock options shall cease on the
         date of termination.

         (d) Termination by the Company without Just Cause Or Resignation for
         Good Reason (Other Than Change in Control). Company will have the right
         to terminate Executive's employment with Company at any time without
         Just Cause. In the event Executive is terminated without Just Cause or
         resigns for Good Reason (as defined below), and upon the execution of a
         full general release by Executive ("Release", attached as Exhibit B),
         releasing all claims known or unknown that Executive may have against
         Company as of the date Executive signs such release, and upon the
         written acknowledgment of his continuing obligations under the
         Confidentiality Agreement, attached as Exhibit A, Executive shall be
         entitled to receive the following Severance Benefits: (i) continuation
         of Executive's base salary, then in effect, for a period of twelve (12)
         months following the Termination Date, paid on the same basis and at
         the same time as previously paid; (ii) payment of any accrued but
         unused vacation and sick leave; (iii) the Company shall reimburse
         Executive, on a grossed-up basis, for the after-tax payment of the
         premiums of Executive's supplemental disability plan and supplemental
         life insurance plan for a period of 24 months following a Termination
         without Just Cause or for reasons other than Change in Control; and
         (iv) the Company shall pay the premiums of Executive's group health
         insurance COBRA continuation coverage, including coverage for
         Executive's eligible dependents, for a maximum period of twelve (12)
         months following a Termination without Just Cause or for reasons other
         than Change in Control; provided, however, that (a) the Company shall
         pay premiums for Executive's eligible dependents only for coverage for
         which those eligible dependents were enrolled immediately prior to the
         Change in Control Termination and (b) the Company's obligation to pay
         such premiums shall cease immediately upon Executive's eligibility for
         comparable group health insurance provided by a new employer of
         Executive.

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         (e) Change in Control Severance Benefits. In the event that the Company
         terminates Executive's employment without Just Cause or Executive
         resigns for Good Reason within one (1) month prior to or thirteen (13)
         months following the effective date of a Change in Control (as defined
         below), ("Change in Control Termination"), and upon the execution of a
         Release (Exhibit B), Executive shall be entitled to receive the
         following Change in Control Severance Benefits: (i) continuation of
         Executive's base salary, then in effect, for a period of two (2) years
         following the Termination Date, paid on the same basis and at the same
         time as previously paid; (ii) payment of any accrued but unused
         vacation and sick leave; (iii) the Company shall reimburse Executive,
         on a grossed-up basis, for the after-tax payment of the premiums of
         Executive's supplemental disability plan and supplemental life
         insurance plan for a period of 24 months following a Termination
         without Just Cause or for reasons other than Change in Control; (iv) a
         bonus in the amount equal to the bonus amount paid in the year
         immediately preceding the Change in Control; and (v) the Company shall
         pay the premiums of Executive's group health insurance COBRA
         continuation coverage, including coverage for Executive's eligible
         dependents, for a maximum period of eighteen (18) months following a
         Change in Control Termination; provided, however, that (a) the Company
         shall pay premiums for Executive's eligible dependents only for
         coverage for which those eligible dependents were enrolled immediately
         prior to the Change in Control Termination and (b) the Company's
         obligation to pay such premiums shall cease immediately upon
         Executive's eligibility for comparable group health insurance provided
         by a new employer of Executive. If Executive obtains new employment
         pursuant to which he is employed on an average of 30 hours or more each
         week he may elect, upon written notification to the Company, to receive
         any unpaid severance benefits (subject to required deductions and tax
         withholdings) within 14 days after receipt by the company of such
         written notice. Executive agrees that the Company's payment of health
         insurance premiums will satisfy its obligations under COBRA for the
         period provided. No premium payments will be made following the
         effective date of Executive's coverage by a health insurance plan of a
         subsequent employer. For the balance of the period that Executive is
         entitled to coverage under federal COBRA law, if any, Executive shall
         be entitled to maintain such coverage at Executive's own expense.

         In addition, in the event the Company terminates Executive's employment
         without Just Cause or that Executive resigns for Good Reason within one
         (1) month prior to or thirteen (13) months following the effective date
         of a Change in Control, the vesting of Executive's then outstanding
         stock options shall be accelerated in full, and the time during which
         such options may be exercised shall be extended to 24 months following
         the date of such Change in Control.

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10. DEFINITIONS.

         (a) Just Cause. As used in this Agreement, "Just Cause" shall mean the
         occurrence of one or more of the following: (i) Executive's conviction
         of a felony or a crime involving moral turpitude or dishonesty; (ii)
         Executive's participation in a fraud or act of dishonesty against the
         Company; (iii) Executive's intentional and material damage to the
         Company's property; (iv) material breach of Executive's employment
         agreement, the Company's written policies, or the Proprietary
         Information and Inventions Agreement that is not remedied by Executive
         within fourteen (14) days of written notice of such breach from the
         Board or conduct by Executive which demonstrates Executive's gross
         unfitness to serve the Company as President or Chief Executive Officer.
         Executive's physical or mental disability or death shall not constitute
         cause hereunder.

         (b) Good Reason. As used in this Agreement, "Good Reason" shall mean
         any one of the following events which occurs on or after the
         commencement of Executive's employment without Executive's consent: (i)
         any reduction of Executive's then existing annual salary base or annual
         bonus target by more than ten percent (10%), unless the Executive
         accepts such change in compensation opportunity; or, (ii) any request
         that the Executive relocate to a work site that would increase the
         Executive's one-way commute distance by more than thirty-five (35)
         miles from his then principal residence, unless the Executive accepts
         such relocation opportunity, or (iii) within 90 days of a Change in
         Control (as defined below) should the Company fail to offer the
         Executive a position that is equivalent in pay, benefits and
         responsibilities.

         (c) Change in Control. As used in this Agreement, a "Change in Control"
         is defined as; (a) a sale, lease, exchange or other transfer in one
         transaction or a series of related transactions of all or substantially
         all of the assets of the Company (other than the transfer of the
         Company's assets to a majority-owned subsidiary corporation); (b) a
         merger or consolidation in which the Company is not the surviving
         corporation (other than a merger or consolidation in which shareholders
         immediately before the merger or consolidation have, immediately after
         the merger or consolidation, greater stock voting power); (c) a reverse
         merger in which the Company is the surviving corporation but the shares
         of the Company's common stock outstanding immediately preceding the
         merger are converted by virtue of the merger into other property,
         whether in the form of securities, cash or otherwise (other than a
         reverse merger in which shareholders immediately before the merger
         have, immediately after the merger, greater stock voting power); or (d)
         any transaction or series of related transactions in which in excess of
         50% of the Company's voting power is transferred.

         11. TERMINATION OF COMPANY'S OBLIGATIONS. Notwithstanding any
         provisions in this Agreement to the contrary, the Company's
         obligations, and Executive's rights pursuant to Sections 9(d) and 9(e)
         herein, regarding salary continuation and the payment of COBRA
         premiums, shall cease and be rendered a nullity immediately should
         Executive fail to comply with the provisions of the Proprietary
         Information & Inventions Agreement attached hereto as Exhibit A or if
         Executive directly or indirectly competes with the Company.

         12. CONTINUATION OF EMPLOYMENT/RESTRICTIVE COVENANT. Executive
         acknowledges that he will be a member of executive and management
         personnel at the Company. Executive further acknowledges that during
         his employment at the Company, he will be privy to extremely sensitive,
         confidential and valuable commercial information, which constitutes
         trade secrets belonging to the Company, the disclosure of which
         information and secrets would greatly harm the Company. Accordingly,
         during the term of Executive's employment and for a period of twelve
         (12) months immediately following Executive's termination, Executive
         shall not without first obtaining the prior written approval of the
         Company, directly or indirectly engage or prepare to engage, in any
         activities in competition with the Company, or accept employment or
         establish a business relationship with a business that directly
         competes with the Company with regard to radiation sensitizers.

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13. NONSOLICITATION. While employed by the Company, and for twelve (12) months
immediately following the Executive's termination of employment, Executive
agrees not to interfere with the business of the Company by soliciting,
attempting to solicit, inducing, or otherwise causing any employee of the
Company to terminate his or her employment in order to become an employee,
consultant or independent contractor to or for any competitor of the Company.

14. MISCELLANEOUS.

         (a) Taxes. Executive agrees to be responsible for the payment of any
         taxes due on any and all compensation, stock option, or benefits
         provided by the Company pursuant to this Agreement.

         (b) Modification/Waiver. This Agreement may not be amended, modified,
         superseded, canceled, renewed or expanded, or any terms or covenants
         hereof waived, except by a writing executed by each of the parties
         hereto or, in the case of a waiver, by the party waiving compliance.
         Failure of any party at any time or times to require performance of any
         provision hereof shall in no manner affect his or its right at a later
         time to enforce the same. No waiver by a party of a breach of any term
         or covenant contained in this Agreement, whether by conduct or
         otherwise, in any one or more instances shall be deemed to be or
         construed as a further or continuing waiver of agreement contained in
         the Agreement.

         (c) Severability. Whenever possible, each provision of this Agreement
         will be interpreted in such manner as to be effective and valid under
         applicable law, but if any provision of this Agreement is held to be
         invalid, illegal or unenforceable in any respect under any applicable
         law or rule in any jurisdiction, such invalidity, illegality or
         unenforceability will not affect any other provision or any other
         jurisdiction, but this Agreement will be reformed, construed and
         enforced in such jurisdiction as if such invalid, illegal or
         unenforceable provisions had never been contained herein.

         (d) Successors and Assigns. This Agreement is intended to bind and
         inure to the benefit of and be enforceable by Executive and the
         Company, and their respective successors, assigns, heirs, executors and
         administrators, except that Executive may not assign any of his duties
         hereunder and he may not assign any of his rights hereunder without the
         written consent of the Company, which shall not be withheld
         unreasonably.

         (e) Notices. All notices given hereunder shall be given by certified
         mail, addressed, or delivered by hand, to the other party at his or its
         address as set forth herein, or at any other address hereafter
         furnished by notice given in like manner. Executive promptly shall
         notify Company of any change in Executive's address. Each notice shall
         be dated the date of its mailing or delivery and shall be deemed given,
         delivered or completed on such date.

         (f) Governing Law; Personal Jurisdiction and Venue. This Agreement and
         all disputes relating to this Agreement shall be governed in all
         respects by the laws of the State of Colorado as such laws are applied
         to agreements between Colorado residents entered into and performed
         entirely in Colorado. The Parties acknowledge that this Agreement
         constitutes the minimum contacts to establish personal jurisdiction in
         Colorado and agree to Colorado court's exercise of personal
         jurisdiction. The Parties further agree that any disputes relating to
         this Agreement shall be brought in courts located in the State of
         Colorado.

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         (g) Entire Agreement. This Agreement together with the Exhibits A and B
         attached hereto set forth the entire agreement and understanding of the
         parties hereto with regard to the employment of the Executive by the
         Company and supersede and any and all prior agreements, arrangements
         and understandings, written or oral, pertaining to the subject matter
         hereof. No representation, promise or inducement relating to the
         subject matter hereof has been made to a party that is not embodied in
         these Agreements, and no party shall be bound by or liable for any
         alleged representation, promise or inducement not so set forth.

         (h) Survival. The following provisions of this Agreement shall survive
         the termination of Executive's employment and the assignment of this
         Agreement by the Company to any successor in interest or other
         assignee: Section 8, Section 12 and Section 13.

         (i) Injunctive Relief. Executive acknowledges that the restrictions set
         forth in Sections 8, 12, and 13 above are necessary to protect the
         Company's confidential proprietary information and other legitimate
         business interests and are reasonable in all respects, including
         duration, territory and scope of activity restricted. Executive further
         acknowledges that the provisions of Sections 8, 12 and 13 hereof are
         essential to the Company, that the Company would not enter into this
         Agreement if it did not include these provisions and that damages
         sustained by the Company as a result of a breach of these provisions
         cannot be adequately remedied by damages, and Executive agrees that the
         Company, in addition to any other remedy it may have under this
         Agreement or at law, shall be entitled to injunctive and other
         equitable relief to prevent or curtail any breach of Sections 8, 12 and
         13 of this Agreement. Executive agrees that the existence of any claim
         or cause of action by Executive against the Company or its affiliates,
         whether predicated on this Agreement or otherwise, shall not constitute
         a defense to the enforcement by the Company of any of the provisions of
         Sections 8, 12 and 13 hereof. Executive shall have no right to enforce
         any of his rights under this Agreement by seeking or obtaining
         injunctive or other equitable relief and acknowledges that damages are
         an adequate remedy for any breach by the Company of this Agreement.

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IN WITNESS WHEREOF, the parties have each duly executed this Restated Employment
Agreement as of the day and year first above written.

                                 ALLOS THERAPEUTICS, INC.

                                 By: /s/ STEPHEN HOFFMAN
                                 Its: Member of the Board of Directors

                                 EXECUTIVE:

                                 /s/ MICHAEL E. HART
                                 Michael E. Hart

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                                    EXHIBIT A

                   MANAGER, EXECUTIVE PERSONNEL OR ASSISTANTS'
                      PROPRIETARY INFORMATION, INVENTIONS,
                 NON-COMPETITION, AND NON-SOLICITATION AGREEMENT
                                    Colorado

This Manager, Executive Personnel or Assistants' Proprietary Information,
Inventions, Non-competition, and Non-solicitation Agreement ("Agreement") is
made in consideration for my employment or continued employment by ALLOS
THERAPEUTICS, INC. or its subsidiaries or affiliates (the "Company"), and the
compensation now and hereafter paid to me. I hereby agree as follows:

1.            NONDISCLOSURE.

              1.1 Recognition of Company's Rights; Nondisclosure. At all times
              during my employment and thereafter, I will hold in strictest
              confidence and will not disclose, use, lecture upon or publish any
              of the Company's Proprietary Information (defined below), except
              as such disclosure, use or publication may be required in
              connection with my work for the Company, or unless an officer of
              the Company expressly authorizes such in writing. I will obtain
              Company's written approval before publishing or submitting for
              publication any material (written, verbal, or otherwise) that
              relates to my work at Company and/or incorporates any Proprietary
              Information. I hereby assign to the Company any rights I may have
              or acquire in such Proprietary Information and recognize that all
              Proprietary Information shall be the sole property of the Company
              and its assigns.

              1.2 Proprietary Information. The term "Proprietary Information"
              shall mean any and all confidential and/or proprietary knowledge,
              data or information of the Company. By way of illustration but not
              limitation, "Proprietary Information" includes (a) trade secrets,
              inventions, mask works, ideas, processes, formulas, source and
              object codes, data, programs, other works of authorship, know-how,
              improvements, discoveries, developments, designs and techniques
              (hereinafter collectively referred to as "Inventions"); and (b)
              information regarding plans for research, development, new
              products, marketing and selling, business plans, budgets and
              unpublished financial statements, licenses, prices and costs,
              suppliers and customers; and (c) information regarding the skills
              and compensation of other employees of the Company.
              Notwithstanding the foregoing, it is understood that, at all such
              times, I am free to use information which is generally known in
              the trade or industry, which is not gained as result of a breach
              of this Agreement, and my own, skill, knowledge, know-how and
              experience to whatever extent and in whichever way I wish.

              1.3 Third Party Information. I understand, in addition, that the
              Company has received and in the future will receive from third
              parties confidential or proprietary information ("Third Party
              Information") subject to a duty on the Company's part to maintain
              the confidentiality of such information and to use it only for
              certain limited purposes. During the term of my employment and
              thereafter, I will hold Third Party Information in the strictest
              confidence and will not disclose to anyone (other than Company
              personnel who need to know such information in connection with
              their work for the Company) or use, except in connection with my
              work for the Company, Third Party Information unless expressly
              authorized by an officer of the Company in writing.

              1.4 No Improper Use of Information of Prior Employers and Others.
              During my employment by the Company I will not improperly use or
              disclose any confidential information or trade secrets, if any, of
              any former employer or any other person to whom I have an
              obligation of

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              confidentiality, and I will not bring onto the premises of the
              Company any unpublished documents or any property belonging to any
              former employer or any other person to whom I have an obligation
              of confidentiality unless consented to in writing by that former
              employer or person. I will use in the performance of my duties
              only information which is generally known and used by persons with
              training and experience comparable to my own, which is common
              knowledge in the industry or otherwise legally in the public
              domain, or which is otherwise provided or developed by the
              Company.

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2.            ASSIGNMENT OF INVENTIONS.

              2.1 Proprietary Rights. The term "Proprietary Rights" shall mean
              all trade secret, patent, copyright, mask work and other
              intellectual property rights throughout the world.

              2.2 Prior Inventions. Inventions, if any, patented or unpatented,
              which I made prior to the commencement of my employment with the
              Company are excluded from the scope of this Agreement. To preclude
              any possible uncertainty, I have set forth on Exhibit A (Previous
              Inventions) attached hereto a complete list of all Inventions that
              I have, alone or jointly with others, conceived, developed or
              reduced to practice or caused to be conceived, developed or
              reduced to practice prior to the commencement of my employment
              with the Company, that I consider to be my property or the
              property of third parties and that I wish to have excluded from
              the scope of this Agreement (collectively referred to as "Prior
              Inventions"). If disclosure of any such Prior Invention would
              cause me to violate any prior confidentiality agreement, I
              understand that I am not to list such Prior Inventions in Exhibit
              A but am only to disclose a cursory name for each such invention,
              a listing of the party(ies) to whom it belongs and the fact that
              full disclosure as to such inventions has not been made for that
              reason. A space is provided on Exhibit A for such purpose. If no
              such disclosure is attached, I represent that there are no Prior
              Inventions. If, in the course of my employment with the Company, I
              incorporate a Prior Invention into a Company product, process or
              machine, the Company is hereby granted and shall have a
              nonexclusive, royalty-free, irrevocable, perpetual, worldwide
              license (with rights to sublicense through multiple tiers of
              sublicensees) to make, have made, modify, use and sell such Prior
              Invention. Notwithstanding the foregoing, I agree that I will not
              incorporate, or permit to be incorporated, Prior Inventions in any
              Company Inventions without the Company's prior written consent.

              2.3 Assignment of Inventions. Subject to Sections 2.4, and 2.6, I
              hereby assign and agree to assign in the future (when any such
              Inventions or Proprietary Rights are first reduced to practice or
              first fixed in a tangible medium, as applicable) to the Company
              all my right, title and interest in and to any and all Inventions
              (and all Proprietary Rights with respect thereto) whether or not
              patentable or registrable under copyright or similar statutes,
              made or conceived or reduced to practice or learned by me, either
              alone or jointly with others, during the period of my employment
              with the Company. Inventions assigned to the Company, or to a
              third party as directed by the Company pursuant to this Section 2,
              are hereinafter referred to as "Company Inventions."

              2.4 Nonassignable Inventions. I recognize that, in the event of a
              specifically applicable state law, regulation, rule, or public
              policy ("Specific Inventions Law"), this Agreement will not be
              deemed to require assignment of any invention which qualifies
              fully for protection under a Specific Inventions Law by virtue of
              the fact that any such invention was, for example, developed
              entirely on my own time without using the Company's equipment,
              supplies, facilities, or trade secrets and neither related to the
              Company's actual or anticipated business, research or development,
              nor resulted from work performed by me for the Company. In the
              absence of a Specific Inventions Law, the preceding sentence will
              not apply.

<PAGE>

              2.5 Obligation to Keep Company Informed. During the period of my
              employment and for six months after the last day of my employment
              with the Company, I will promptly disclose to the Company fully
              and in writing all Inventions authored, conceived or reduced to
              practice by me, either alone or jointly with others. In addition,
              I will promptly disclose to the Company all patent applications
              filed by me or on my behalf within a year after termination of
              employment. At the time of each such disclosure, I will advise the
              Company in writing of any Inventions that I believe fully qualify
              for protection under the provisions of a Specific Inventions Law;
              and I will at that time provide to the Company in writing all
              evidence necessary to substantiate that belief. The Company will
              keep in confidence and will not use for any purpose or disclose to
              third parties without my consent any confidential information
              disclosed in writing to the Company pursuant to this Agreement
              relating to Inventions that qualify fully for protection under a
              Specific Inventions Law. I will preserve the confidentiality of
              any Invention that does not fully qualify for protection under a
              Specific Inventions Law.

              2.6 Government or Third Party. I also agree to assign all my
              right, title and interest in and to any particular Invention to a
              third party, including without limitation the United States, as
              directed by the Company.

              2.7 Works for Hire. I acknowledge that all original works of
              authorship which are made by me (solely or jointly with others)
              within the scope of my employment and which are protectable by
              copyright are "works made for hire," pursuant to United States
              Copyright Act (17 U.S.C., Section 101).

              2.8 Enforcement of Proprietary Rights. I will assist the Company
              in every proper way to obtain, and from time to time enforce,
              United States and foreign Proprietary Rights relating to Company
              Inventions in any and all countries. To that end I will execute,
              verify and deliver such documents and perform such other acts
              (including appearances as a witness) as the Company may reasonably
              request for use in applying for, obtaining, perfecting,
              evidencing, sustaining and enforcing such Proprietary Rights and
              the assignment thereof. In addition, I will execute, verify and
              deliver assignments of such Proprietary Rights to the Company or
              its designee. My obligation to assist the Company with respect to
              Proprietary Rights relating to such Company Inventions in any and
              all countries shall continue beyond the termination of my
              employment, but the Company shall compensate me at a reasonable
              rate after my termination for the time actually spent by me at the
              Company's request on such assistance.

              In the event the Company is unable for any reason, after
              reasonable effort, to secure my signature on any document needed
              in connection with the actions specified in the preceding
              paragraph, I hereby irrevocably designate and appoint the Company
              and its duly authorized officers and agents as my agent and
              attorney in fact, which appointment is coupled with an interest,
              to act for and in my behalf to execute, verify and file any such
              documents and to do all other lawfully permitted acts to further
              the purposes of the preceding paragraph with the same legal force
              and effect as if executed by me. I hereby waive and quitclaim to
              the Company any and all claims, of any nature whatsoever, which I
              now or may hereafter have for infringement of any Proprietary
              Rights assigned hereunder to the Company.

              3. NO CONFLICTS OR SOLICITATION. I acknowledge that during my
              employment I will have access to and knowledge of Proprietary
              Information. I also acknowledge that during my employment with the
              Company, I have held and/or will hold a management or executive
              position or am, or will be, an assistant to a manager or
              executive. To protect the Company's Proprietary Information, I
              agree that during the period of my employment by the Company I
              will not, without the Company's express written consent, engage in
              any other employment or business activity directly related to the
              business in which the Company is now involved or becomes involved,
              nor will I engage in any other activities which conflict with my
              obligations to the Company. To protect the Company's Proprietary
              Information, and because of the position in the Company that I
              hold, I agree that during my employment with the Company whether
              full-time or part-time and for a period of one year after my last
              day of employment with the Company, I will not (a) directly or
              indirectly solicit or induce any employee of the Company to
              terminate or negatively alter his or her relationship with the
              Company or (b) directly or indirectly solicit the business of any
              client or customer of the Company (other than on behalf of the
              Company) or (c) directly or indirectly induce any client,
              customer, supplier, vendor, consultant or independent contractor
              of the Company to terminate or negatively alter his, her or its
              relationship with the Company. I agree that the geographic scope
              of the non-solicitation should include the "Restricted Territory"
              (as defined below).

<PAGE>

4. If any restriction set forth in this Section is found by any court of
competent jurisdiction to be unenforceable because it extends for too long a
period of time or over too great a range of activities or in too broad a
geographic area, it shall be interpreted to extend only over the maximum period
of time, range of activities or geographic area as to which it may be
enforceable.

5. COVENANT NOT TO COMPETE. I acknowledge that during my employment I will have
access to and knowledge of Proprietary Information. I also acknowledge that
during my employment with the Company, I have held and/or will hold a management
or executive position or am, or will be, an assistant to a manager or executive.
To protect the Company's Proprietary Information, and because of the position in
the Company that I may hold, I agree that during my employment with the Company
whether full-time or part-time and for a period of one year after my last day of
employment with the Company, I will not directly or indirectly engage in
(whether as an employee, consultant, proprietor, partner, director or
otherwise), or have any ownership interest in, or participate in the financing,
operation, management or control of, any person, firm, corporation or business
that engages in a "Restricted Business" in a "Restricted Territory" (as defined
below). It is agreed that ownership of (i) no more than one percent (1%) of the
outstanding voting stock of a publicly traded corporation, or (ii) any stock I
presently own shall not constitute a violation of this provision.

              5.1 Reasonable. I agree and acknowledge that the time limitation
              on the restrictions in this paragraph, combined with the
              geographic scope, is reasonable. I also acknowledge and agree that
              this paragraph is reasonably necessary for the protection of
              Company's Proprietary Information as defined in paragraph 1.2
              herein, that through my employment I shall receive adequate
              consideration for any loss of opportunity associated with the
              provisions herein, and that these provisions provide a reasonable
              way of protecting Company's business value which will be imparted
              to me. If any restriction set forth in this paragraph 4 is found
              by any court of competent jurisdiction to be unenforceable because
              it extends for too long a period of time or over too great a range
              of activities or in too broad a geographic area, it shall be
              interpreted to extend only over the maximum period of time, range
              of activities or geographic area as to which it may be
              enforceable.

              5.2 As used herein, the terms:

              (i) "Restricted Business" shall mean the development or
              commercialization of radiosensitizers.

              (ii) "Restricted Territory" shall mean any state, county, or
              locality in the United States in which the Company conducts
              business and any other country, city, state, jurisdiction, or
              territory in which the Company does business.

              6. RECORDS. I agree to keep and maintain adequate and current
              records (in the form of notes, sketches, drawings and in any other
              form that may be required by the Company) of all Proprietary
              Information developed by me and all Inventions made by me during
              the period of my employment at the Company, which records shall be
              available to and remain the sole property of the Company at all
              times.

              7. NO CONFLICTING OBLIGATION. I represent that my performance of
              all the terms of this Agreement and as an employee of the Company
              does not and will not breach any agreement to keep in confidence
              information acquired by me in confidence or in trust prior to my
              employment by the Company. I have not entered into, and I agree I
              will not enter into, any agreement either written or oral in
              conflict herewith.

              8. RETURN OF COMPANY MATERIALS. When I leave the employ of the
              Company, I will deliver to the Company any and all drawings,
              notes, memoranda, specifications, devices, formulas, and
              documents, together with all copies thereof, and any other
              material containing or disclosing any Company Inventions, Third
              Party Information or Proprietary Information of the Company,
              unless agreed to by the Company. I further agree that any property
              situated on the Company's premises and owned by the Company,
              including disks and other storage media, filing cabinets or other
              work areas, is subject to inspection by Company personnel at any
              time with or without notice.

<PAGE>

9. LEGAL AND EQUITABLE REMEDIES. Because my services are personal and unique and
because I may have access to and become acquainted with the Proprietary
Information of the Company, the Company shall have the right to enforce this
Agreement and any of its provisions by injunction, specific performance or other
equitable relief, without bond and without prejudice to any other rights and
remedies that the Company may have for a breach of this Agreement.

10. NOTICES. Any notices required or permitted hereunder shall be given to the
appropriate party at the address specified below or at such other address as the
party shall specify in writing. Such notice shall be deemed given upon personal
delivery to the appropriate address or if sent by certified or registered mail,
three days after the date of mailing.

11. NOTIFICATION OF NEW EMPLOYER. In the event that I leave the employ of the
Company, I hereby consent to the notification of my new employer of my rights
and obligations under this Agreement.

12.           GENERAL PROVISIONS.

              12.1 Governing Law; Consent to Personal Jurisdiction and Exclusive
              Forum. This Agreement will be governed by and construed according
              to the laws of the State of Colorado as such laws are applied to
              agreements entered into and to be performed entirely within
              Colorado between Colorado residents. I hereby expressly understand
              and consent that my employment is a transaction of business in the
              State of Colorado and constitutes the minimum contacts necessary
              to make me subject to the personal jurisdiction of the federal
              courts located in the State of Colorado, and the state courts
              located in the County of Denver, Colorado, for any lawsuit filed
              against me by Company arising from or related to this Agreement. I
              agree and acknowledge that any controversy arising out of or
              relating to this Agreement or the breach thereof, or any claim or
              action to enforce this Agreement or portion thereof, or any
              controversy or claim requiring interpretation of this Agreement
              must be brought in a forum located within the State of Colorado.
              No such action may be brought in any forum outside the State of
              Colorado. Any action brought in contravention of this paragraph by
              one party is subject to dismissal at any time and at any stage of
              the proceedings by the other, and no action taken by the other in
              defending, counter claiming or appealing shall be construed as a
              waiver of this right to immediate dismissal. A party bringing an
              action in contravention of this paragraph shall be liable to the
              other party for the costs, expenses and attorney's fees incurred
              in successfully dismissing the action or successfully transferring
              the action to the federal courts located in the State of Colorado,
              or the state courts located in the County of Denver, Colorado.

              12.2 Severability. In case any one or more of the provisions
              contained in this Agreement shall, for any reason, be held to be
              invalid, illegal or unenforceable in any respect, such invalidity,
              illegality or unenforceability shall not affect the other
              provisions of this Agreement, and this Agreement shall be
              construed as if such invalid, illegal or unenforceable provision
              had never been contained herein. If moreover, any one or more of
              the provisions contained in this Agreement shall for any reason be
              held to be excessively broad as to duration, geographical scope,
              activity or subject, it shall be construed by limiting and
              reducing it, so as to be enforceable to the extent compatible with
              the applicable law as it shall then appear.

              12.3 Successors and Assigns. This Agreement will be binding upon
              my heirs, executors, administrators and other legal
              representatives and will be for the benefit of the Company, its
              successors, and its assigns.

              12.4 Survival. The provisions of this Agreement shall survive the
              termination of my employment and the assignment of this Agreement
              by the Company to any successor in interest or other assignee.

<PAGE>

              12.5 Employment. I agree and understand that my employment is
              at-will which means I or the company each have the right to
              terminate my employment at will, with or without advanced notice
              and with or without cause. I further agree and understand that
              nothing in this Agreement shall confer any right with respect to
              continuation of employment by the Company, nor shall it interfere
              in any way with my right or the Company's right to terminate my
              employment at any time, with or without cause.

<PAGE>

              12.6 Waiver. No waiver by the Company of any breach of this
              Agreement shall be a waiver of any preceding or succeeding breach.
              No waiver by the Company of any right under this Agreement shall
              be construed as a waiver of any other right. The Company shall not
              be required to give notice to enforce strict adherence to all
              terms of this Agreement.

              12.7 Entire Agreement. The obligations pursuant to Sections 1
              through 4 and Sections 6 and 7 (including all subparts) of this
              Agreement shall apply to any time during which I was previously
              employed, or am in the future employed, by the Company as a
              consultant if no other agreement governs nondisclosure and
              assignment of inventions during such period. This Agreement is the
              final, complete and exclusive agreement of the parties with
              respect to the subject matter hereof and supersedes and merges all
              prior discussions between us. No modification of or amendment to
              this Agreement, nor any waiver of any rights under this Agreement,
              will be effective unless in writing and signed by the party to be
              charged. Any subsequent change or changes in my duties, salary or
              compensation will not affect the validity or scope of this
              Agreement.

              This Agreement shall be effective as of the _______________, 2001.

              I HAVE READ THIS AGREEMENT CAREFULLY AND UNDERSTAND ITS TERMS. I
              HAVE COMPLETELY FILLED OUT EXHIBIT A TO THIS AGREEMENT.

Dated:

Michael E. Hart

ACCEPTED AND AGREED TO:

<PAGE>

                                    EXHIBIT B

TO:                Allos Therapeutics, Inc.

FROM:              Michael E. Hart

DATE:

SUBJECT:           Previous Inventions

1. Except as listed in Section 2 below, the following is a complete list of all
inventions or improvements relevant to the subject matter of my employment by
Allos Therapeutics, Inc. that have been made or conceived or first reduced to
practice by me alone or jointly with others prior to my engagement by the
Company:

               [ ]          No inventions or improvements.

               [ ]          See below:

               [ ]          No inventions or improvements.

               [ ]          See below:

               [ ]          Additional sheets attached.

2. Due to a prior confidentiality agreement, I cannot complete the disclosure
under Section 1 above with respect to inventions or improvements generally
listed below, the proprietary rights and duty of confidentiality with respect to
which I owe to the following party(ies):

<Table>
<Caption>
          Invention or Improvement                       Party(ies)                             Relationship
<S>                                               <C>                                 <C>

1.
               -----------------------             -----------------------             -----------------------

2.
               -----------------------             -----------------------             -----------------------

3.
               -----------------------             -----------------------             -----------------------
</Table>

               [ ]          Additional sheets attached.

<PAGE>

                                    EXHIBIT B

                                RELEASE AGREEMENT

I understand that my position with Allos Therapeutics, Inc. (the "Company")
terminated effective ___________, _____ (the "Separation Date"). The Company has
agreed that if I choose to sign this Release, the Company will pay me certain
severance or consulting benefits pursuant to the terms of the Executive
Employment (the "Agreement") between myself and the Company, and any agreements
incorporated therein by reference. I understand that I am not entitled to such
benefits unless I sign this Release and it becomes fully effective. I understand
that, regardless of whether I sign this Release, the Company will pay me all of
my accrued salary and vacation through the Separation Date, to which I am
entitled by law.

In consideration for the severance benefits I am receiving under the Agreement,
I hereby release the Company and its officers, directors, agents, attorneys,
employees, shareholders, parents, subsidiaries, and affiliates from any and all
claims, liabilities, demands, causes of action, attorneys' fees, damages, or
obligations of every kind and nature, whether they are now known or unknown,
arising at any time prior to the date I sign this Release. This general release
includes, but is not limited to: all federal and state statutory and common law
claims, claims related to my employment or the termination of my employment or
related to breach of contract, tort, wrongful termination, discrimination, wages
or benefits, or claims for any form of equity or compensation. Notwithstanding
the release in the preceding sentence, I am not releasing any right of
indemnification I may have for any liabilities arising from my actions within
the course and scope of my employment with the Company.

If I am forty (40) years of age or older as of the Separation Date, I
acknowledge that I am knowingly and voluntarily waiving and releasing any rights
I may have under the federal Age Discrimination in Employment Act of 1967, as
amended ("ADEA"). I also acknowledge that the consideration given for the waiver
in the above paragraph is in addition to anything of value to which I was
already entitled. I have been advised by this writing, as required by the ADEA
that: (a) my waiver and release do not apply to any claims that may arise after
my signing of this Release; (b) I should consult with an attorney prior to
executing this Release; (c) I have twenty-one (21) days within which to consider
this Release (although I may choose to voluntarily execute this Release
earlier); (d) I have seven (7) days following the execution of this release to
revoke the Release; and (e) this Release will not be effective until the eighth
day after this Release has been signed both by me and by the Company ("Effective
Date").

Agreed:

ALLOS THERAPEUTICS.INC.                         MICHAEL E. HART

By:

Name:

Title:

Date:                                   Date:<PAGE>
                                                                   EXHIBIT 10.20

               EMPLOYMENT SEPARATION AND GENERAL RELEASE AGREEMENT

This Employment Separation and General Release Agreement ("Separation
Agreement") is entered into by and between Michael J. Gerber, M.D. ("Dr.
Gerber"), an individual, and Allos Therapeutics, Inc. ("Allos"), and shall
become effective on the Effective Date as defined in Section 16 below. Dr.
Gerber and Allos may be collectively referred to herein as the "Parties."

                                    RECITALS

A. Effective September 24, 2001, Dr. Gerber has resigned his position as Senior
Vice President, Clinical Development and Regulatory Affairs and any and all
other positions Dr. Gerber may have held with Allos, or any affiliate or
subsidiary of Allos.

B. The Parties wish the make the separation amicable but conclusive on the terms
and conditions set forth herein.

C. Dr. Gerber accepts the benefits of this Separation Agreement with the
acknowledgment that by its terms he has been fully and satisfactorily
compensated.

                                    COVENANTS

In consideration of the mutual covenants and promises set forth in this
Separation Agreement, including Dr. Gerber's general release of claims and
covenant not to sue, the Parties agree as follows:

1. Resignation. Dr. Gerber resigned as Senior Vice President, Clinical
Development and Regulatory Affairs, and any and all other positions Dr. Gerber
may have held with the Allos and any of affiliates or subsidiaries of Allos,
effective as of September 24, 2001, at 5:00 p.m. (the "Separation Date"). Dr.
Gerber acknowledges that he has received payment of all wages and compensation,
including payment for all accrued vacation benefits and bonuses, that he earned
up through the Separation Date, subject to standard payroll deductions and
withholdings.

2. Severance Benefits. As part of the consideration for the mutual covenants and
promises contained in this Separation Agreement, including Dr. Gerber's general
release of claims and covenant not to sue, Dr. Gerber will be eligible to
receive the following severance benefits:

                    a. Severance Pay. Subject to the terms and conditions of
                    this Separation Agreement, Dr. Gerber shall receive
                    severance pay ("Severance Pay") in the gross sum of
                    $256,781.20 which is equal to 52 weeks of his weekly base
                    compensation. The Severance Pay will be subject to all
                    required deductions and tax withholdings. The Severance Pay
                    will be paid in equal installments in accordance with Allos'
                    normal payroll cycle during the 52-week period following the
                    Effective Date of this Agreement as defined in Section 16
                    below.

                    b. Disability Insurance Premiums. Allos shall reimburse Dr.
                    Gerber, on a grossed-up basis, for the premium costs he
                    incurs in continuing in effect the supplemental disability
                    insurance policy under which he is now insured for a period
                    of 24-months following the Separation Date.

<PAGE>

                    c. COBRA Insurance Premiums. For purposes of the
                    Consolidated Omnibus Budget Reconciliation Act, the
                    applicable COBRA period (typically 18 months) will begin
                    September 25, 2001. Pursuant to the terms and conditions of
                    COBRA and Allos' group medical and dental insurance plan,
                    Dr. Gerber may continue his participation and his
                    dependents' participation in Allos' medical and dental
                    insurance plan for the applicable COBRA period by making
                    required COBRA payments. Dr. Gerber acknowledges that Allos
                    has provided him with a COBRA notification setting forth his
                    rights and responsibilities with respect to COBRA coverage.
                    As part of the consideration for the mutual covenants and
                    promises contained in this Separation Agreement, including
                    Dr. Gerber's release of claims and promise not to sue,
                    should Dr. Gerber timely elect to continue medical and
                    dental insurance coverage pursuant to COBRA, Allos agrees to
                    pay Dr. Gerber's COBRA monthly premiums for the period
                    beginning September 25, 2001 and ending September 24, 2002
                    to maintain medical and dental insurance coverage that is
                    similar to that coverage he and his dependents received
                    through Allos immediately prior to the Separation Date.
                    After September 24, 2002, Dr. Gerber will be responsible for
                    paying the COBRA monthly premiums. Notwithstanding the
                    foregoing, Allos' obligation to pay Dr. Gerber's COBRA
                    monthly premiums shall cease immediately upon Dr. Gerber's
                    eligibility for comparable group health insurance provided
                    by a new employer. Dr. Gerber agrees to promptly notify
                    Allos in writing should he become eligible for any medical
                    or dental insurance benefits through a new employer.

                    3. Stock Options.

                    a. As of the Separation Date, Dr. Gerber had the following
                    outstanding options (collectively, the "Options") to
                    purchase shares of Allos' Common Stock:

                            i.            Options to purchase 31,000 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on March 4, 1999,
                                          under Allos' 1995 Stock Option Plan
                                          (the "1995 Plan"), of which 31,000
                                          options are vested;

                            ii.           Options to purchase 31,000 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on March 4, 1999,
                                          under the 1995 Plan, of which 31,000
                                          options are vested;

                            iii.          Options to purchase 31,000 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on May 12, 1999,
                                          under the 1995 Plan, of which 31,000
                                          options are vested;

                            iv.           Options to purchase 85,571 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on August 31,
                                          1999, under the 1995 Plan, of which
                                          46,350 options are vested;

                                       2
<PAGE>

                            v.            Options to purchase 67,432 shares of
                                          Common Stock pursuant to a
                                          Non-Qualified Stock Option granted on
                                          August 31, 1999, under the 1995 Plan,
                                          of which 36,525 options are vested;

                            vi.           Options to purchase 31,000 shares of
                                          Common Stock pursuant to a
                                          Non-Qualified Stock Option granted on
                                          August 31, 1999, under the 1995 Plan,
                                          of which 31,000 options are vested;

                            vii.          Options to purchase 31,000 shares of
                                          Common Stock pursuant to a
                                          Non-Qualified Stock Option granted on
                                          August 31, 1999, under the 1995 Plan,
                                          of which zero (0) options are vested;

                            viii.         Options to purchase 36,167 shares of
                                          Common Stock pursuant to a
                                          Non-Qualified Stock Option granted on
                                          January 12, 2000, under the 1995 Plan,
                                          of which zero (0) options are vested;

                            ix.           Options to purchase 41,333 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on January 12,
                                          2000, under the 1995 Plan, of which
                                          zero (0) options are vested;

                            x.            Options to purchase 28,500 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on March 1, 2001,
                                          under Allos' 2000 Stock Incentive
                                          Compensation Plan (the "2000 Plan"
                                          and, together with the 1995 Plan, the
                                          "Stock Option Plans") of which zero
                                          (0) options are vested; and

                            xi.           Options to purchase 9,500 shares of
                                          Common Stock pursuant to an Incentive
                                          Stock Option granted on July 17, 2001,
                                          under the 2000 Plan, of which zero (0)
                                          options are vested.

                            b. The Parties acknowledge and agree that, upon Dr.
              Gerber's execution of the Consulting Agreement (as defined in
              Section 5 below), the Options shall continue to be governed and
              controlled by the terms and conditions of such Options and the
              applicable Stock Option Plans. Dr. Gerber is advised by Allos to
              seek independent legal advice with respect to tax and securities
              laws regarding his Options, including their status as incentive
              stock options, and any sale of Allos stock that he may wish to
              make, in addition to consulting the applicable Stock Option Plan.

                            c. Except for the occurrence of Dr. Gerber's
              resignation, which Allos intends to publicly announce as soon as
              reasonably practicable following the execution of this Separation
              Agreement, each of Allos and Dr. Gerber hereby represent to the
              other party that they have no knowledge of any material,
              non-public information that would restrict or otherwise affect Dr.
              Gerber ability to exercise any vested Options or sell any shares
              of Allos common stock pursuant to Allos' policies against insider
              trading.

                                       3
<PAGE>

4. Transition Assistance. As part of the consideration for the mutual covenants
and promises contained in this Separation Agreement, including Allos' provision
of the severance benefits pursuant to Section 2 above, Dr. Gerber agrees to
reasonably assist Allos in the transition of his job duties, responsibilities
and knowledge to other Allos employees as reasonably requested by Allos. Dr.
Gerber's obligation to provide such transition assistance shall terminate four
months after the Separation Date and shall be limited to 20 hours each month
during the four month transition period.

5. Consulting Agreement. As part of the consideration for the mutual covenants
and promises contained in this Separation Agreement, including Dr. Gerber's
general release of claims and covenant not to sue, Allos and Dr. Gerber are
simultaneously entering into a consulting agreement, a copy of which is attached
hereto as Exhibit 1 (the "Consulting Agreement").

6. Dr. Gerber's General Release and Covenant Not to Sue. Dr. Gerber, for
himself, his heirs and assigns, does hereby release and discharge Allos and its
present, past and future subsidiaries, divisions, parent and affiliated
companies, and their respective shareholders, directors, officers, employees,
agents, insurers and attorneys (collectively referred to hereafter as the "Allos
Released Parties"), of and from, and promises not to sue or assert against the
Allos Released Parties, for any purpose, all claims, causes of action, damages,
losses, liabilities and demands whatsoever including, but not limited to, any
claim arising from or related to or attributable to Dr. Gerber's employment with
any of the Allos Released Parties and the termination of such employment. This
release includes, but is not limited to, all matters which may arise under
common law or under federal, state, or local laws, including, but not limited
to, all claims under the Age Discrimination in Employment Act, as amended, 29
U.S.C. Sections 621, et seq. ("ADEA"), Title VII of the Civil Rights Act of
1964, as amended, the Civil Rights Act of 1991, the Americans with Disabilities
Act of 1990, the Fair Labor Standards Act, the Worker Adjustment and Retraining
Notification Act ("WARN Act"), the Colorado Antidiscrimination Act, and the
Colorado Wage Claim Act. Dr. Gerber understands and agrees that his release of
claims under this Separation Agreement extends to all claims of every nature and
kind, known and unknown, suspected or unsuspected, presently existing or which
may arise in the future caused by or resulting from or attributable to any act
or omission of the Allos Released Parties occurring prior to Dr. Gerber's
execution of this Separation Agreement. Allos understands and agrees that Dr.
Gerber is not waiving any right or claim which may arise after the date he
executes this Separation Agreement which is based upon any act or omission of
Allos or the Allos Released Parties occurring after his execution of this
Separation Agreement.

7. Dr. Gerber's Acknowledgment Concerning Release of ADEA Claims. Dr. Gerber
expressly acknowledges and agrees that, by entering into this Separation
Agreement, he is waiving any and all rights or claims that he may have under the
Age Discrimination in Employment Act of 1967 ("ADEA"), as amended, which have
arisen on or before the date of his execution of this Separation Agreement. Dr.
Gerber further expressly acknowledges and agrees that:

                                       4
<PAGE>

                    a. In exchange for Dr. Gerber's waiver of any and all rights
                    or claims under the ADEA arising on or before the date of
                    his execution of this Separation Agreement, he will receive
                    consideration in addition to any consideration which he was
                    already entitled to receive before executing this Separation
                    Agreement;

                    b. Dr. Gerber was advised in writing by this Separation
                    Agreement to consult with an attorney of his choice and at
                    his expense prior to his execution of this Separation
                    Agreement;

                    c. A copy of this Separation Agreement was delivered to Dr.
                    Gerber on September 24, 2001, and he was informed in writing
                    by this Separation Agreement that he has twenty-one (21)
                    days within which to consider the Separation Agreement;

                    d. If Dr. Gerber executes this Separation Agreement prior to
                    the expiration of the 21-day period mentioned above, he
                    voluntarily does so thereby waiving the 21-day period; and

                    e. Dr. Gerber was informed that he has seven (7) days
                    following his execution of this Separation Agreement in
                    which to revoke the Separation Agreement.

                    8. Continuing Obligations Under the Non-Competition
                    Agreement and Sections 12 and 13 of the Employment
                    Agreement.

                    a. Subject to the amendment set forth below, Dr. Gerber
                    understands and agrees that notwithstanding the termination
                    of his employment relationship with Allos, he remains
                    subject to the terms and conditions of Sections 12 and 13 of
                    that certain Employment Agreement dated January 17, 2001 by
                    and between Dr. Gerber and Allos (the "Employment
                    Agreement"). The Parties hereby agree that the final
                    sentence of Section 12 of the Employment Agreement shall be
                    amended to read as follows:

                    Accordingly, during the term of Executive's employment and
                    for a period of twelve (12) months immediately following
                    Executive's resignation, Executive shall not without first
                    obtaining the written approval of the Company, directly or
                    indirectly engage or prepare to engage, in any activities in
                    the United States or Canada in competition with the Company,
                    or accept employment or establish a business relationship
                    with a business located in the United Sates or Canada that
                    directly competes with the Company with regard to radiation
                    sensitizers.

                    b. Subject to the amendment set forth below, Dr. Gerber
                    understands and agrees that notwithstanding the termination
                    of his employment relationship with Allos, he remains
                    subject to the terms and conditions of that certain
                    Non-Competition, Proprietary Information and Inventions
                    Agreement attached to the Employment Agreement as Exhibit A
                    (the "Non-Competition Agreement"). The Parties hereby agree
                    that the definition of "Restricted Business" as set forth in
                    Section 5.2(i) of the Non-Competition Agreement shall be
                    amended to read as follows:

                                       5
<PAGE>

                    "Restricted Business" shall mean the research, design,
                    development, marketing or sales of any technology or product
                    that is based upon or utilizes radiation sensitizers.

                    c. Notwithstanding any provisions in this Separation
                    Agreement to the contrary, Allos' obligations to provide
                    severance benefits pursuant to Section 2 above, and Dr.
                    Gerber's rights to receive such severance benefits, shall
                    cease and be rendered a nullity immediately should Dr.
                    Gerber fail to comply with the Non-Competition Agreement and
                    Sections 12 and 13 of the Employment Agreement, as amended
                    herein.

                    9. Return of Allos Property. Dr. Gerber represents and
                    affirms that he has returned to Allos all Allos property in
                    his possession or control including, but not limited to,
                    such items as corporate credit cards, keys, equipment on
                    loan, files, documents, computer hardware and software,
                    computer accessories, manuals, note books, and all other
                    corporate property belonging to Allos.

                    10. Non-Disparagement. As part of the consideration for the
                    mutual covenants and promises contained in this Separation
                    Agreement, (i) Allos agrees not to disparage or otherwise
                    make negative statements or comments about or relating to
                    Dr. Gerber; and (ii) Dr. Gerber agrees not to disparage or
                    otherwise make negative statements or comments about or
                    relating to Allos, the Allos Released Parties, Allos'
                    products and services, investigators who collaborate with
                    Allos on its products, and analysts who analyze Allos'
                    business. This provision is a material term of this
                    Separation Agreement and Dr. Gerber understands that Allos'
                    willingness to provide him with the severance benefits set
                    forth in Section 2 above is based, in part, on his agreement
                    to comply with the requirements of this Section 10. Thus,
                    notwithstanding any provisions in this Separation Agreement
                    to the contrary, Allos' obligations to provide severance
                    benefits pursuant to Section 2 above, and Dr. Gerber's
                    rights to receive such severance benefits, shall cease and
                    be rendered a nullity immediately should Dr. Gerber fail to
                    comply with this Section 10.

                    11. Non-Solicitation and Non-Interference. In addition to
                    his obligations under the Non-Competition Agreement, Dr.
                    Gerber agrees that during the period he is receiving the
                    Severance Pay under Section 2 above, he will not (i)
                    directly or indirectly interfere with Allos' relationship
                    with any employee, consultant, investor, shareholder,
                    investigator, or analyst, (ii) directly or indirectly hire
                    or attempt to hire any employee or consultant of Allos to
                    work for any person, firm or entity of or for which Dr.
                    Gerber is an officer, director, employee, consultant or
                    owner of equity or other financial interest, or (iii)
                    directly or indirectly assist any other person or entity in
                    employing or soliciting for employment any employee or
                    consultant of Allos. This provision is a material term of
                    this Separation Agreement and Dr. Gerber understands that
                    Allos' willingness to provide him with the severance
                    benefits set forth in Section 2 above is based, in part, on
                    his agreement to comply with the requirements of this
                    Section 11. Thus, notwithstanding any provisions in this
                    Separation Agreement to the contrary, Allos' obligations to
                    provide severance benefits pursuant to Section 2 above, and
                    Dr. Gerber's rights to receive such severance benefits,
                    shall cease and be rendered a nullity immediately should Dr.
                    Gerber fail to comply with his obligations under this
                    Section 11.

                                       6
<PAGE>

12. Confidentiality. The provisions of this Separation Agreement shall be held
in strictest confidence by Dr. Gerber and Allos and shall not be publicized or
disclosed in any manner whatsoever. Each of Dr. Gerber and Allos acknowledges,
represents and agrees that he or it, respectively, has not and will not disclose
the terms or provisions of this Separation Agreement to any current, former or
future employee of Allos, or of any of its subsidiaries, divisions, and
affiliates, other than, in the case of Allos, officers or employees who have a
need to know in connection with the performance of their duties. Notwithstanding
the prohibitions contained in this Section 12: (i) the Parties may disclose this
Separation Agreement in confidence to their respective legal and financial
advisors (and family members in the case of Dr. Gerber), each of whom shall be
advised of and be required to adhere to this Separation Agreement's
confidentiality requirement, (ii) Allos may disclose this Separation Agreement
as necessary to fulfill standard or legally required corporate or securities law
reporting or disclosure requirements or to comply with standard due diligence
requests in connection with any financings, mergers or acquisitions, or other
business transactions; (iii) Allos may disclose this Separation Agreement upon
request from any governmental entity; and (iv) the Parties may disclose this
Separation Agreement insofar as disclosure may be necessary to enforce one or
more terms of this Separation Agreement. This provision is a material term of
this Separation Agreement and Dr. Gerber understands that Allos' willingness to
provide him with the severance benefits set forth in Section 2 above is based,
in part, on his agreement to comply with the requirements of this Section 12.
Thus, notwithstanding any provisions in this Separation Agreement to the
contrary, Allos' obligations to provide severance benefits pursuant to Section 2
above, and Dr. Gerber's rights to receive such severance benefits, shall cease
and be rendered a nullity immediately should Dr. Gerber fail to comply with his
obligations under this Section 12.

13. Opportunity to Review and Consider Separation Agreement. Dr. Gerber
acknowledges that a copy of this Separation Agreement was delivered to him on
September 24, 2001, and that he has been given a period of 21 calendar days to
review, analyze and consider this Separation Agreement before signing it. Dr.
Gerber further acknowledges that he understands this Separation Agreement in its
entirety.

14. Right to Revoke Separation Agreement. Dr. Gerber may revoke this Separation
Agreement, and, in particular, may revoke his waiver of any and all rights or
claims under the ADEA arising on or before the date of his execution of this
Separation Agreement, during the seven (7) days following his execution of this
Separation Agreement. Any revocation of this Separation Agreement must be in
writing and hand-delivered during the revocation period to Barbara Baring,
Allos' Vice President of Human Resources.

15. Legal Advice. Dr. Gerber acknowledges that he has been advised to consult
with an attorney of his own choice and at his own expense before executing this
Separation Agreement and that he has been given an opportunity to do so.

                                       7
<PAGE>

16. Effective Date. The Effective Date of this Separation Agreement shall be the
eighth day after Dr. Gerber signs and returns this Separation Agreement to Allos
so long as he does not exercise his right to revoke this Separation Agreement as
set forth in Section 12 above. In the event Dr. Gerber fails to sign and return
this Separation Agreement to Allos on or before October 17, 2001, or revokes
this Separation Agreement within 7 days after he signs it, this Separation
Agreement and the attached Consulting Agreement will be null and void.

17. Miscellaneous.

                    a. Modification/Waiver. This Separation Agreement may not be
                    amended, modified, superseded, canceled, renewed or
                    expanded, or any terms or covenants hereof waived, except by
                    a writing executed by each of the Parties hereto or, in the
                    case of a waiver, by the party waiving compliance. Failure
                    of any party at any time or times to require performance of
                    any provision hereof shall in no manner affect his or its
                    right at a later time to enforce the same. No waiver by a
                    party of a breach of any term or covenant contained in this
                    Separation Agreement, whether by conduct or otherwise, in
                    any one or more instances shall be deemed to be or construed
                    as a further or continuing waiver of agreement contained in
                    the Separation Agreement.

                    b. Entire Agreement. This Separation Agreement, the
                    Consulting Agreement, the Non-Competition Agreement and
                    Sections 12 and 13 of the Employment Agreement constitute
                    and contain the entire agreement and understanding between
                    the Parties concerning the subject matters addressed herein
                    and therein and supersedes and replaces all prior
                    negotiations and agreements, proposed or otherwise, whether
                    written or oral, concerning the subject matters of this
                    Separation Agreement. By way of example, and without
                    limitation, this Separation Agreement supersedes Section 9
                    of the Employment Agreement, and this Separation Agreement
                    extinguishes Allos' obligation to provide Dr. Gerber with
                    any severance benefits under the Employment Agreement.

                    c. Severability. If any provision of this Separation
                    Agreement or any application thereof is held invalid, the
                    invalidity shall not affect other provisions or applications
                    of this Separation Agreement which can be given effect
                    without the invalid provision or application.

                    d. Notices. All notices given hereunder shall be given by
                    certified mail, addressed, or delivered by hand, to the
                    other party at his or its address as set forth below, or at
                    any other address hereafter furnished by notice given in
                    like manner. Dr. Gerber promptly shall notify Allos of any
                    change of his address. Each notice shall be dated the date
                    of its mailing or delivery and shall be deemed given,
                    delivered or completed on such date.

                                       8
<PAGE>

                    Michael J. Gerber, MD
                    500 Clermont Street
                    Denver, CO 80220

                    Allos  Therapeutics, Inc.
                    Attn:  Stephen J. Hoffman, MD
                    President, Chief Executive Officer
                    11080 CirclePoint Road
                    Westminster, CO 80020

          e. Governing Law; Personal Jurisdiction and Venue; Enforcement. This
          Separation Agreement and all disputes relating to this Separation
          Agreement shall be governed in all respects by the laws of the State
          of Colorado as such laws are applied to agreements between Colorado
          residents entered into and performed entirely in Colorado. The Parties
          acknowledge that this Separation Agreement constitutes the minimum
          contacts to establish personal jurisdiction in Colorado and agree to
          Colorado court's exercise of personal jurisdiction. The Parties
          further agree that any dispute relating to this Agreement shall be
          brought in a court located in the State of Colorado and that the
          prevailing party in such a dispute shall be entitled to an award of
          his or its costs and expenses incurred in such dispute, including his
          or its reasonable attorney's fees, in addition to any other relief to
          which the party may be entitled.

          f. Counterparts. This Separation Agreement may be executed by
          facsimile signature and may be executed in several counterparts, each
          of which shall be deemed an original and all of which taken together
          shall constitute a single instrument. Photographic copies of such
          executed counterparts may be used in lieu of the original for any
          purpose.

          DR. GERBER AND ALLOS HEREBY ACKNOWLEDGE THAT THEY HAVE READ THIS
          SEPARATION AGREEMENT, THAT THEY FULLY UNDERSTAND ITS FINAL AND BINDING
          EFFECT, THAT THE ONLY PROMISES MADE TO THEM TO SIGN THIS SEPARATION
          AGREEMENT ARE THOSE STATED ABOVE, AND THAT THEY ARE SIGNING THIS
          SEPARATION AGREEMENT VOLUNTARILY.

                 [Remainder of page is intentionally left blank]

                                       9
<PAGE>

IN WITNESS WHEREOF, the undersigned parties have executed this Agreement as of
the 3rd day of October, 2001.

                                         ALLOS THERAPEUTICS, INC.

                                         By: /s/ STEPHEN J. HOFFMAN
                                            -----------------------------------
                                            Stephen J. Hoffman, MD
                                            President, Chief Executive Officer

STATE OF COLORADO               )
                                )     ss
COUNTY OF BROOMFIELD            )

The foregoing instrument was acknowledged before me this 16th day of November,
2001, by Stephen J. Hoffman MD, as President, Chief Executive Officer of Allos
Therapeutics, Inc.

           Witness my hand and official seal.

           My commission expires:

                                                        /s/ SHARON A. SMITH
                                                            Notary Public

                                                      /s/ MICHAEL J. GERBER
                                                      MICHAEL J. GERBER, M.D.

STATE OF COLORADO               )
                                )     ss
COUNTY OF DENVER                )

The foregoing instrument was acknowledged before me this 16th day of November,
2001, by Michael J. Gerber, M.D.

           Witness my hand and official seal.

           My commission expires:  6/10/2002
                                                        /s/ MILDRED C. MORIE
                                                            Notary Public

                                       10
<PAGE>

                                   EXHIBIT ONE

                              CONSULTING AGREEMENT

This Consulting Agreement ("Consulting Agreement") is made and entered into
effective this 24th day of September, 2001, by and between Allos Therapeutics,
Inc., a Delaware corporation (the "Company"), located at 11080 CirclePoint Road,
Westminster, CO 80020, and Michael J. Gerber, M.D. ("Consultant"). The Company
and the Consultant may be collectively referred to herein as the "Parties."

                                    RECITALS

A. Consultant has been employed by the Company since July 1994 and was a party
to an employment agreement with the Company dated January 17, 2001.

B. The Parties are terminating their employment relationship pursuant to an
Employment Separation and General Release Agreement (the "Separation
Agreement"). As part of the Separation Agreement, Consultant is required to
provide certain transition assistance to the Company by assisting in the
transition of his job duties, responsibilities and knowledge to other Company
employees. Consultant is required to provide this transition assistance for up
to 20 hours per month during the four-month period immediately following the
termination of the Parties' employment relationship.

C. The Company would like to retain Consultant to provide certain consulting
services relating to his areas of expertise and Consultant is willing to provide
such consulting services. The Parties understand and agree that the consulting
services will be independent of and separate from the transition assistance
Consultant is required to provide under the Separation Agreement. The Parties
are thus entering into this Consulting Agreement to govern their rights and
obligations with respect to Consultant's provision of such consulting services.

                                    AGREEMENT

In consideration of the mutual promises and covenants contained herein, the
Parties agree as follows:

1. Term of Agreement: Unless sooner terminated in accordance with Section 9
below, this Consulting Agreement shall remain in full force and effect and shall
bind the Parties for a period of one year from the effective date hereof. The
Parties may renew this Consulting Agreement for additional periods upon mutual
written agreement.

                                        2
<PAGE>

2. Consultant Obligations: As requested from time to time by the Company's
executive officers, Consultant shall provide consulting services (the
"Consulting Services") which relate to his areas of expertise and which the
Company's executive officers believe would be beneficial to the Company. The
specific nature and amount of the Consulting Services that Consultant may be
requested to perform by the Company under this Consulting Agreement shall be
within the sole discretion of the Company. Consultant shall perform the
Consulting Services at his offices unless otherwise agreed to by the Parties.
Consultant agrees to make himself available to provide the Consulting Services
at the times reasonably requested by the Company; provided that, the Company
will reasonably cooperate with Consultant in the event that he has conflicts in
connection with his other obligations, whether such obligations are work related
or personal.

3. Company Obligations: The Company shall compensate Consultant at the rate of
$2,500 per day for the time he actually spends in providing the Consulting
Services. A "day" for purposes of this Consulting Agreement shall mean not less
than eight hours spent during a given day in the performance of the Consulting
Services. In the event Consultant spends less than eight hours during a given
day providing the Consulting Services, he shall be compensated on a prorated
basis for that day (i.e., If Consultant spends five hours on a given day
providing the Consulting Services, he shall be compensated for that day at the
rate of 5/8 x $2,500). With respect to travel time, Consultant shall be
compensated only for time spent actually performing the Consulting Services; he
shall not be compensated for travel time during which Consulting Services are
not performed. In addition, the Company shall provide reimbursement at cost for
those reasonable expenses incurred by Consultant in performing the Consulting
Services, such as long distance telephone calls, actual travel costs at the
lowest available rate for 7-day advanced fare purchases (unless the Company
requests Consultant to travel on less than 7 days' notice), and materials
requested by the Company. Reasonably detailed invoices, together with
accompanying documentation regarding any expenses for which reimbursement is
sought, shall be submitted on at least a monthly basis and payment will be
forwarded no later than 30 days after receipt of the invoice. Consulting
services shall be compensated pursuant to the foregoing provisions both during
the four 4 month transition period and during the entire term of this Agreement.
The Consultant shall not be required to provide more than 20 hours of
non-compensated transition services during each of the first 4 months and,
accordingly, all hours in excess of 20 in each such month shall be deemed
consulting.

                                        3

<PAGE>

          4. Independent Contractor:

          a) Consultant's relationship with the Company is that of an
          independent contractor, and nothing in this Consulting Agreement
          should be construed to create a partnership, joint venture, or
          employer-employee relationship. Consultant is not the agent of the
          Company and is not authorized to make any representation, contract, or
          commitment on behalf of Company without the written consent of an
          officer of the Company. Consultant will not be entitled to any of the
          benefits which the Company may make available to its employees, such
          as group insurance, profit-sharing, or retirement benefits. The
          Consultant will be solely responsible for all tax returns and payments
          required to be filed with or made to any federal, state or local tax
          authority with respect to Consultant's performance of the Consulting
          Services and his receipt of fees under this Consulting Agreement. The
          Company will regularly report amounts paid to Consultant by filing
          Form 1099-MISC with the Internal Revenue Service as required by law.
          Because Consultant is an independent contractor, the Company will not
          withhold or make payments for social security; make unemployment
          insurance or disability insurance contributions; or obtain worker's
          compensation insurance on Consultant's behalf. Consultant agrees to
          accept exclusive liability for complying with all applicable state and
          federal laws governing self-employed individuals, including
          obligations such as payment of taxes, social security, disability and
          other contributions based on fees paid to Consultant, his agents or
          employees under this Consulting Agreement.

          b) Consultant acknowledges that if he is injured while performing the
          Consulting Services hereunder, he will not be covered for such injury
          under the Company's insurance policies, including under any Worker's
          Compensation coverage provided by the Company for its employees.
          Consultant further acknowledges that he is solely responsible for
          providing Worker's Compensation insurance for any of his employees.

          5. Other Activities: Consultant is free to enter into any contract to
          provide consulting services to other businesses, entities, or
          individuals, during the term of this Consulting Agreement, unless such
          contract would violate the provisions of this Consulting Agreement or
          the Separation Agreement, would induce Consultant to breach any
          provision of this Consulting Agreement or the Separation Agreement, or
          would prevent or restrict Consultant from satisfying Consultant's
          obligations under this Consulting Agreement.

          6. Stock Options: For so long as this Consulting Agreement remains in
          effect, Consultant's Options shall continue to vest pursuant to the
          terms of the Options and the applicable Stock Option Plans. The
          Parties acknowledge and agree that upon the termination of this
          Consulting Agreement, (i) Dr. Gerber will have ninety (90) days
          following the date of such termination (the "Termination Date") to
          exercise all Options (as defined in Section 3 of the Separation
          Agreement) which are vested as of the Termination Date; and (ii) all
          Options which have not vested as of the Termination Date will
          terminate and revert to the Company as of the Termination Date, all in
          accordance with the terms and conditions of such Options and the
          applicable Stock Option Plan (as defined in Section 3 of the
          Separation Agreement). The Parties further acknowledge and agree that,
          Dr. Gerber is advised by the Company to seek independent legal advice
          with respect to tax and securities laws regarding his Options and any
          sale of Company stock he may wish to make, in addition to consulting
          the terms and conditions of the Options and the Stock Option Plans.

                                        4

<PAGE>

          7. Proprietary Information:

          a) In addition to his obligations under the Separation Agreement,
          Consultant agrees that he shall not, at any time during the term of
          this Consulting Agreement and for a period of ten years thereafter,
          whether or not in the employ of the Company, disclose, communicate, or
          divulge to, or use for his personal benefit or for the benefit of any
          person, firm, association, or corporation other than the Company, any
          reproductions or materials of any kind, any proprietary information,
          knowledge, or information with respect to techniques used by the
          Company in connection with its operations, any business methods,
          business policies or any other information relating to or dealing with
          the policies or practices of the Company, made known to Consultant by
          the Company or any of its officers or employees, or learned by
          Consultant while in the employ of the Company or communicated to or
          acquired by Consultant while in the employment of Company without the
          prior written consent of Company. Consultant further covenants and
          agrees that the termination of this Consulting Agreement shall not
          release Consultant from the foregoing obligations, and that such
          knowledge or information which Consultant has obtained or may obtain
          in the course of providing the Consulting Services under this
          Consulting Agreement will be kept confidential for such ten-year
          period and not revealed to any competitor firms, corporations,
          associations, and other persons whatsoever.

          b) Upon the expiration or earlier termination of this Consulting
          Agreement, Consultant covenants and agrees to deliver to the Company
          any articles or papers which have come into Consultant's possession
          during the performance of the Consulting Services for the Company or
          which Consultant holds for the Company irrespective of whether such
          data, lists, papers, or records were prepared by Consultant or not.

          8. Allos Inventions: The Consultant agrees that the Company has
          exclusive rights and ownership to any ideas, inventions, writings or
          other developments conceived or contributed to or by Consultant as
          part of his provision of the Consulting Services to the Company. At
          the request of the Company, Consultant will assist in executing any
          documents reasonably required to confirm any proprietary rights or
          patents that the Company may pursue. By entering into this Consulting
          Agreement, Consultant acknowledges that he will return any and all
          Company property or materials in his possession at the termination of
          this Consulting Agreement or at the request of the Company.

                                        5

<PAGE>

9. Termination: Notwithstanding any provisions in this Consulting Agreement to
the contrary, this Consulting Agreement and Consultant's status as a consultant
shall automatically terminate upon any of the following occurrences:

          a) Consultant's material breach of any provision of this Consulting
          Agreement that is not remedied within 30 days after written notice of
          such breach is provided to Consultant by the Company's Board of
          Directors;

          b) Consultant's breach of any provision of the Separation Agreement;

          c) Consultant's failure to sign the Separation Agreement on or before
          October 17, 2001;

          d) Consultant's revocation of the Separation Agreement at any time
          during the eight day period after he signs it;

          e) The initiation of any legal proceeding or administrative action by
          Consultant against the Company; or

          f) Written notice by Consultant to the Company that he wishes to
          terminate this Consulting Agreement.

          10. Severability: If any provision of this Consulting Agreement or any
          application thereof is held invalid, the invalidity shall not affect
          other provisions or applications of this Consulting Agreement which
          can be given effect without the invalid provision or application.

          11. Entire Agreement: This Consulting Agreement and the Separation
          Agreement constitute and contain the entire agreement and
          understanding between the Parties concerning the subject matters
          addressed herein and supersede and replace all prior negotiations and
          agreements, proposed or otherwise, whether written or oral, concerning
          the subject matters of this Consulting Agreement. This Consulting
          Agreement shall not be altered, amended, or changed except by a
          writing executed by each of the Parties hereto or, in the case of a
          waiver, by the party waiving compliance.

          12. Governing Law; Personal Jurisdiction and Venue; Enforcement. This
          Consulting Agreement and all disputes relating to this Consulting
          Agreement shall be governed in all respects by the laws of the State
          of Colorado as such laws are applied to agreements between Colorado
          residents entered into and performed entirely in Colorado. The Parties
          acknowledge that this Consulting Agreement constitutes the minimum
          contacts to establish personal jurisdiction in Colorado and agree to
          Colorado courts' exercise of personal jurisdiction. The Parties
          further agree that any dispute relating to this Consulting Agreement
          shall be brought in a court located in the State of Colorado and that
          the prevailing party in such a dispute shall be entitled to an award
          of his or its costs and expenses incurred in such dispute, including
          his or its reasonably attorney's fees, in addition to any other relief
          to which the party may be entitled.

          13. Assignment: This Consulting Agreement and the rights and
          obligations hereunder shall be and hereby are non-assignable in whole
          or in part by Consultant. It is understood and agreed that Consultant
          shall not be permitted to assign, subcontract or appoint any agent or
          subagent for the performance of any part of his duties and obligations
          hereunder. This Consulting Agreement shall otherwise be binding upon
          and inure to the benefit of the successors and assigns of the Parties
          hereto.

                                        6

<PAGE>

IN WITNESS WHEREOF, this Agreement has been executed as of the date set forth
above.

Allos Therapeutics, Inc.                        CONSULTANT

/s/ STEPHEN J. HOFFMAN                          /s/ MICHAEL J. GERBER
Stephen J. Hoffman, MD                          Signature

Title: President, Chief Executive Officer       Date:  11/16/01

Date:  11/16/01                                 Social Security No.: ###-##-####

                                        7

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