Document:

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                                                                   EXHIBIT 10.21

                                GENOMICA, INC.
                           STOCK OPTION GRANT NOTICE
                           (1996 Stock Option Plan)

                                [Standard ISO]

Genomica Corporation (the "Company"), pursuant to its Amended and Restated 1996
Stock Option Plan (the "Plan"), hereby grants to Optionee an option to purchase
the number of shares of the Company's common stock set forth below. This option
is subject to all of the terms and conditions as set forth herein and in
Attachments I, II, and III, which are incorporated herein in their entirety.

Optionee:                               ____________________________

Date of Grant:                          ____________________________

Vesting Commencement Date:              ____________________________

Shares Subject to Option:               ____________________________

Exercise Price Per Share:               ____________________________

Expiration Date:                        ____________________________

                              ____ Incentive Stock Option (as defined by (S) 422
                                   of the Code)

                              ____ Nonstatutory Stock Option

Vesting Schedule:             [25%] vested on the one year anniversary of the
                              Vesting Commencement Date; 1/48 vests on each
                              monthly anniversary thereafter.

Payment: By cash or check.

Additional Terms/Acknowledgements: The undersigned Optionee acknowledges receipt
of, and understands and agrees to, this Grant Notice, the Stock Option Agreement
and the Plan. Optionee further acknowledges that as of the Date of Grant, this
Grant Notice, the Stock Option Agreement and the Plan set forth the entire
understanding between Optionee and the Company regarding the acquisition of
stock in the Company and supersede all prior oral and written agreements on that
subject with the exception of (i) options previously granted and delivered to
Optionee under the Plan, and (ii) the following agreements only:

     Other Agreements:          _______________________________________
                                _______________________________________
                                _______________________________________
<PAGE>

GENOMICA CORPORATION                              OPTIONEE:

By:___________________________________            ______________________________
                                                  Signature

Title:________________________________

Date:_________________________________            Date:_________________________

Attachment I:   Stock Option Agreement
Attachment II:  1996 Stock Option Plan
Attachment III: Notice of Exercise

                                      2.
<PAGE>

                             GENOMICA CORPORATION

                            STOCK OPTION AGREEMENT

     Pursuant to the Grant Notice and this Stock Option Agreement, the Company
has granted you an option to purchase the number of shares of the Company's
common stock ("Common Stock") indicated in the Grant Notice at the exercise
price indicated in the Grant Notice.

     Your option is granted in connection with and in furtherance of the
Company's compensatory benefit plan for the Company's employees (including
officers), directors or consultants, and is intended to comply with the
provisions of Rule 701 promulgated by the Securities and Exchange Commission
under the Securities Act of 1933, as amended (the "Securities Act").  Defined
terms not explicitly defined in this Stock Option Agreement but defined in the
Amended and Restated 1996 Stock Option Plan (the "Plan") shall have the same
definitions as in the Plan.

     The details of your option are as follows:

     1.   Vesting. Subject to the limitations contained herein, your option will
vest as provided in the Grant Notice, provided that vesting will cease upon the
termination of your Continuous Service.

     2.   Method Of Payment. Payment of the exercise price by cash or check is
due in full upon exercise of all or any part of your option.

     3.   Whole Shares.  Your option may only be exercised for whole shares.

     4.   Securities Law Compliance. In order for the option granted under this
agreement to be exercised, there must be an exemption from the Federal
Securities laws for the issuance of stock. In the event no such exemption is
available, you may be prohibited from exercising your option.

     5.   Term. The term of your option commences on the date of grant and
expires upon the earliest of:

               (i)   the Expiration Date indicated in the Grant Notice;

               (ii)  the day before the tenth (10th) anniversary of the Date of
Grant;

               (iii) twelve (12) months after your death, if you die during, or
within three (3) months after the termination of your Continuous Service; or

               (iv)  twelve (12) months after the termination of your Continuous
Service due to disability; or

               (v)   three (3) months after the termination of your Continuous
Service for any other reason, provided that if: (a) during any part of such
three (3) month period the option is not exercisable solely because of the
condition set forth in paragraph 4 (Securities Law

                                      1.
<PAGE>

Compliance), in which event the option shall not expire until the earlier of the
Expiration Date or until it shall have been exercisable for an aggregate period
of three (3) months after the termination of Continuous Service, and (b)
exercise of the option within three (3) months after termination of your
Continuous Service would result in liability under section 16(b) of the
Securities Exchange Act of 1934 (the "Exchange Act"), the option will expire on
the earliest of (i) the Expiration Date, (ii) the tenth (10th) day after the
last date upon which exercise would result in such liability or (iii) six (6)
months and ten (10) days after the termination of your Continuous Service.

          The Company has provided for continued vesting or extended
exercisability of your option under certain circumstances for your benefit, but
cannot guarantee that your option will necessarily be treated as an "incentive
stock option".

     6.   Exercise.

          (a)  You may exercise the vested portion of your option during its
term (and the unvested portion of your option if the Grant Notice so permits) by
delivering a notice of exercise (in a form designated by the Company) together
with the exercise price to the Secretary of the Company, or to such other person
as the Company may designate, during regular business hours, together with such
additional documents as the Company may then require.

          (b)  By exercising your option you agree that:

               (i)   as a condition to any exercise of your option, the Company
may require you to enter into an arrangement providing for the payment by you to
the Company of any tax withholding obligation of the Company arising by reason
of (1) the exercise of your option; (2) the lapse of any substantial risk of
forfeiture as required by Section 83 of the Internal Revenue Code; or (3) the
disposition of shares acquired upon such exercise;

               (ii)  you will notify the Company in writing within fifteen (15)
days after the date of any disposition of any of the shares of the Common Stock
issued upon exercise of an incentive stock option that occurs within two (2)
years after the date of your option grant or within one (1) year after such
shares of Common Stock are transferred upon exercise of your option; and

               (iii) you will execute and deliver such other agreements as may
be reasonably requested by the Company and/or the underwriter(s) which are
consistent with the provisions of Section 9 below or which are necessary to give
further effect thereto.

     7.   Proprietary Information and Invention Agreement. You acknowledge that
by agreeing to enter into this Stock Option Agreement, you also agree to be
bound by the Company's Proprietary Information and Invention Agreement.

     8.   Transferability. Your option is not transferable, except by will or by
the laws of descent and distribution. Furthermore, during your lifetime, your
option may only be exercised by you. Upon your death, the person to whom your
rights have passed by will or by

                                      2.
<PAGE>

the laws of descent and distribution may exercise your option, so long as they
comply with the Plan.

     9.   Market Standstill. In connection with the first underwritten
registration of the offering of any securities of the Company under the
Securities Act, you agree not to sell or otherwise transfer or dispose of any
shares of Common Stock or other securities of the Company during such period
(not to exceed one hundred eighty (180) days) following the effective date of
the registration statement of the Company filed under the Securities Act as may
be requested by the Company or the representative of the underwriters, provided
that all executive officers and directors of the Company have similarly agreed.
Furthermore, the Company may impose stop-transfer instructions with respect to
securities subject to the foregoing restrictions until the end of such period.

     10.  Right of First Refusal. Before any shares of Common Stock (the
"Shares") issued upon exercise of an option to you or any transferee (either
being sometimes referred to herein as the "Holder") may be sold or otherwise
transferred (including transfer by gift or operation of law), the Company shall
have an assignable right of first refusal to purchase the Shares on the terms
and conditions set forth in this Section 10 (the "Right of First Refusal").

          (a) Notice of Proposed Transfer. The Holder of the Shares shall
deliver to the Company a written notice (the "Notice") stating: (i) the Holder's
bona fide intention to sell or otherwise transfer the Shares; (ii) the name of
each proposed purchaser or other transferee (the "Proposed Transferee"); (iii)
the number of Shares to be transferred to each Proposed Transferee; and (iv) the
bona fide cash price or other consideration for which the Holder proposed to
transfer the Shares (the "Offered Price"); and the Holder shall offer to sell
the Shares at the Offered Price to the Company.

          (b) Exercise of Right of First Refusal. At any time within thirty (30)
days after receipt of the Notice, the Company or its assignee may, by giving
written notice to the Holder, elect to purchase all (but not less than all) of
the Shares proposed to be transferred to any one or more of the Proposed
Transferees, at the Offered Price.

          (c) Payment. Payment of the purchase price shall be made, at the
option of the Company or its assignee, either (i) in cash (by check) or (ii) in
the manner and at the time(s) set forth in the Notice.

          (d) Holder's Right to Transfer. If all the Shares proposed in the
Notice to be transferred to a given Proposed Transferee are not purchased by the
Company and/or its assignee as provided in this Section 10, then the Holder may
sell or otherwise transfer such Shares to that Proposed Transferee at the
Offered Price or at a higher price, provided, that, such sale or other transfer
is consummated within one hundred twenty (120) days after the date of the Notice
and provided further that any such sale or other transfer is effected in
accordance with any applicable securities laws. If the Shares described in the
Notice are not transferred to the Proposed Transferee within such period, a new
Notice shall be given to the Company, and the Company shall again be offered the
Right of First Refusal, before any Shares held by the Holder may be sold or
otherwise transferred.

                                      3.
<PAGE>

          (e) Exception for Certain Family Transfers. Anything to the contrary
contained in this Section 10 notwithstanding, the transfer of any or all of the
Shares during the Optionee's lifetime or on the Optionee's death by will or
intestacy to Optionee's immediate family or to a trust for the benefit of
Optionee or Optionee's immediate family shall be exempt from the provisions of
this Section 10; provided that, as a condition to receiving the Shares, the
transferee or other recipient shall agree in writing to receive and hold the
Shares so transferred subject to the provisions of the Plan, and to transfer
such Shares no further except in accordance with the terms of the Plan. As used
herein, "immediate family" shall mean spouse, lineal descendant or antecedent,
father, mother, brother or sister.

          (f) Termination of Right of First Refusal. The Right of First Refusal
shall terminate as to any Shares upon the first sale of Common Stock of the
Company to the general public pursuant to a registration statement filed with
and declared effective by the Securities and Exchange Commission (other than a
registration statement solely covering an employee benefit plan or corporate
reorganization).

     11.  Option Not a Service Contract. Your option is not an employment
contract and nothing in your option shall be deemed to create in any way
whatsoever any obligation on your part to continue in the employ of the Company,
or of the Company to continue your employment with the Company. In addition,
nothing in your option shall obligate the Company, or any Affiliate of the
Company, or their respective stockholders, Board of Directors, officers or
employees to continue any relationship which you might have as a Director or
Consultant for the Company.

     12.  Notices. Any notices provided for in your option or the Plan shall be
given in writing and shall be deemed effectively given upon receipt or, in the
case of notices delivered by the Company to you, five (5) days after deposit in
the United States mail, postage prepaid, addressed to you at the last address
you provided to the Company.

     13.  Governing Plan Document. Your option is subject to all the provisions
of the Plan, the provisions of which are hereby made a part of your option,
including without limitation the provisions of the Plan relating to option
provisions, and is further subject to all interpretations, amendments, rules and
regulations which may from time to time be promulgated and adopted pursuant to
the Plan. In the event of any conflict between the provisions of your option and
those of the Plan, the provisions of the Plan shall control.

                                      4.<PAGE>
                                                                   EXHIBIT 10.22

                             GENOMICA CORPORATION

                           STOCK OPTION GRANT NOTICE

                          2000 Equity Incentive Plan

Genomica Corporation (the "Company"), pursuant to its 2000 Equity Incentive Plan
(the "Plan"), hereby grants to Participant an option to purchase the number of
shares of the Company's Common Stock set forth below.  This option is subject to
all of the terms and conditions as set forth herein and in the Stock Option
Agreement, the Plan and the Notice of Exercise, all of which are attached hereto
and incorporated herein in their entirety.

Participant:                         ------------------------------------------
Date of Grant:                       ------------------------------------------
Vesting Commencement Date:           ------------------------------------------
Number of Shares Subject to Option:  ------------------------------------------
Exercise Price (Per Share):          ------------------------------------------
Total Exercise Price:                ------------------------------------------
Expiration Date:                     ------------------------------------------

Type of Grant:       [ ] Incentive Stock Option    [ ] Nonstatutory Stock Option

Exercise Schedule:   [ ] Same as Vesting Schedule  [ ] Early Exercise Permitted

Vesting Schedule:    1/4th  of the shares vest one year after the Vesting
                     Commencement Date.
                     1/48th of the shares vest monthly thereafter over the
                     next three years.

Payment:             By one or a combination of the following items (described
                     in the Stock Option Agreement):

                           [ ] By cash or check
                           [ ] Pursuant to a Regulation T Program if the Shares
                               are publicly traded
                           [ ] By delivery of already-owned shares if the
                               Shares are publicly traded
                           [ ] By deferred payment

Additional Terms/Acknowledgements:  The undersigned Optionholder acknowledges
receipt of, and understands and agrees to, this Grant Notice, the Stock Option
Agreement and the Plan.  Optionholder further acknowledges that as of the Date
of Grant, this Grant Notice, the Stock Option Agreement and the Plan set forth
the entire understanding between Optionholder and the Company regarding the
acquisition of stock in the Company and supersede all prior oral and written
agreements on that subject with the exception of (i) options previously granted
and delivered to Optionholder under the Plan, and (ii) the following agreements
only:

     Other Agreements:                  ---------------------------------------
                                        ---------------------------------------

GENOMICA CORPORATION                            Participant:

By:
   ------------------------------------    ------------------------------------
               Signature                                 Signature

Title:                                     Date:
      ---------------------------------         -------------------------------
Date:
     ----------------------------------

Attachments: Stock Option Agreement
             2000 Equity Incentive Plan
             Notice of Exercise

<PAGE>

                                 Attachment I

                            STOCK OPTION AGREEMENT

<PAGE>

                                 Attachment II

                           2000 EQUITY INCENTIVE PLAN

<PAGE>

                                 Attachment III

                               NOTICE OF EXERCISE

<PAGE>

                             GENOMICA CORPORATION
                          2000 Equity Incentive Plan

                            Stock Option Agreement
                  (Incentive and Nonstatutory Stock Options)

     Pursuant to the Stock Option Grant Notice ("Grant Notice") and this Stock
Option Agreement, Genomica Corporation (the "Company") has granted you
("Participant") an option under its 2000 Equity Incentive Plan (the "Plan") to
purchase the number of shares of the Company's Common Stock indicated in the
Grant Notice at the exercise price indicated in the Grant Notice.  Defined terms
not explicitly defined in this Stock Option Agreement but defined in the Plan
shall have the same definitions as in the Plan.

     The details of your option are as follows:

     1.  Vesting. Subject to the limitations contained herein, your option will
vest as provided in the Grant Notice, provided that vesting will cease upon the
termination of your Continuous Service.

     2.  Number of Shares and Exercise Price. The number of shares subject to
your option and your exercise price per share referenced in the Grant Notice may
be adjusted from time to time for Capitalization Adjustments, as provided in the
Plan.

     3.  Exercise prior to Vesting ("Early Exercise"). If permitted in the Grant
Notice (i.e., the "Exercise Schedule" indicates that "Early Exercise" of your
option is permitted) and subject to the provisions of this option, you may elect
at any time that is both (i) during the period of your Continuous Service and
(ii) during the term of your option, to exercise all or part of your option,
including the nonvested portion of your option; provided, however, that:

         (a)  a partial exercise of your option shall be deemed to cover first
vested shares and then the earliest vesting installment of unvested shares;

         (b)  any shares so purchased from installments which have not vested as
of the date of exercise shall be subject to the purchase option in favor of the
Company as described in the Company's form of Early Exercise Stock Purchase
Agreement;

         (c)  you shall enter into the Company's form of Early Exercise Stock
Purchase Agreement with a vesting schedule that will result in the same vesting
as if no early exercise had occurred; and

         (d)  if your option is an incentive stock option, then, as provided in
the Plan, to the extent that the aggregate Fair Market Value (determined at the
time of grant) of stock with respect to which your option plus all other
incentive stock options you hold are exercisable for the first time by you
during any calendar year (under all plans of the Company and its Affiliates)
exceeds one hundred thousand dollars ($100,000), the options or portions thereof
that exceed such limit (according to the order in which they were granted) shall
be treated as nonstatutory stock options.

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<PAGE>

     4.  Method of Payment.  Payment of the exercise price is due in full upon
exercise of all or any part of your option.  You may elect to make payment of
the exercise price in cash or by check or in any other manner permitted by the
Grant Notice, which may include one or more of the following:

         (a)  In the Company's sole discretion at the time your option is
exercised and provided that at the time of exercise the Common Stock is publicly
traded and quoted regularly in The Wall Street Journal, pursuant to a program
developed under Regulation T as promulgated by the Federal Reserve Board which,
prior to the issuance of Common Stock, results in either the receipt of cash (or
check) by the Company or the receipt of irrevocable instructions to pay the
aggregate exercise price to the Company from the sales proceeds.

         (b)  Provided that at the time of exercise the Common Stock is publicly
traded and quoted regularly in The Wall Street Journal, by delivery of already-
owned shares of Common Stock that either have been held for the period required
to avoid a charge to the Company's reported earnings (generally six months) or
were not acquired, directly or indirectly from the Company, that are owned free
and clear of any liens, claims, encumbrances or security interests, and that are
valued at Fair Market Value on the date of exercise. "Delivery" for these
purposes, in the sole discretion of the Company at the time your option is
exercised, shall include delivery to the Company of your attestation of
ownership of such shares of Common Stock in a form approved by the Company.
Notwithstanding the foregoing, your option may not be exercised by tender to the
Company of Common Stock to the extent such tender would constitute a violation
of the provisions of any law, regulation or agreement restricting the redemption
of the Company's stock.

     5.  Whole Shares.  Your option may only be exercised for whole shares.

     6.  Securities Law Compliance.  Notwithstanding anything to the contrary
contained herein, your option may not be exercised unless the shares issuable
upon exercise of your option are then registered under the Securities Act or, if
such shares are not then so registered, the Company has determined that such
exercise and issuance would be exempt from the registration requirements of the
Securities Act.  The exercise of your option must also comply with other
applicable laws and regulations governing the option, and the option may not be
exercised if the Company determines that the exercise would not be in material
compliance with such laws and regulations.

     7.  Term.  The term of your option commences on the Date of Grant and
expires upon the earliest of the following:

         (a)  three (3) months after the termination of your Continuous Service
for any reason other than Disability or death, provided that if during any part
of such three (3) month period the option is not exercisable solely because of
the condition set forth in paragraph 6, the option shall not expire until the
earlier of the Expiration Date or until it shall have been

                                       2
<PAGE>

exercisable for an aggregate period of three (3) months after the termination of
your Continuous Service;

         (b)  twelve (12) months after the termination of your Continuous
Service due to Disability;

         (c)  eighteen (18) months after your death if you die either during
your Continuous Service or within three (3) months after your Continuous Service
terminates ;

         (d)  the Expiration Date indicated in the Grant Notice; or

         (e)  the tenth (10th) anniversary of the Date of Grant.

     If your option is an incentive stock option, note that, to obtain the
federal income tax advantages associated with an "incentive stock option," the
Code requires that at all times beginning on the date of grant of the option and
ending on the day three (3) months before the date of the option's exercise, you
must be an employee of the Company or an Affiliate, except in the event of your
death or your Disability.  The Company has provided for extended exercisability
of your option under certain circumstances for your benefit, but cannot
guarantee that your option will necessarily be treated as an "incentive stock
option" if you provide services to the Company or an Affiliate as a Consultant
or Director or if you exercise your option more than three (3) months after the
date your employment with the Company or an Affiliate terminates.

     8.  Exercise.

         (a)  You may exercise the vested portion of your option (and the
unvested portion of your option if the Grant Notice so permits) during its term
by delivering a Notice of Exercise (in a form designated by the Company)
together with the exercise price to the Secretary of the Company, or to such
other person as the Company may designate, during regular business hours,
together with such additional documents as the Company may then require.

         (b)  By exercising your option you agree that, as a condition to any
exercise of your option, the Company may require you to enter an arrangement
providing for the payment by you to the Company of any tax withholding
obligation of the Company arising by reason of (1) the exercise of your option,
(2) the lapse of any substantial risk of forfeiture to which the shares are
subject at the time of exercise, or (3) the disposition of shares acquired upon
such exercise.

         (c)  If your option is an incentive stock option, by exercising your
option you agree that you will notify the Company in writing within fifteen (15)
days after the date of any disposition of any of the shares of the Common Stock
issued upon exercise of your option that occurs within two (2) years after the
date of your option grant or within one (1) year after such shares of Common
Stock are transferred upon exercise of your option.

         (d)  By exercising your option you agree that the Company (or a
representative of the underwriters) may, in connection with the first
underwritten registration of the offering of

                                       3
<PAGE>

any securities of the Company under the Securities Act, require that you not
sell, dispose of, transfer, make any short sale of, grant any option for the
purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale, any shares of Common Stock or other securities of the
Company held by you, for a period of time specified by the underwriter(s) (not
to exceed one hundred eighty (180) days) following the effective date of the
registration statement of the Company filed under the Securities Act. You
further agree to execute and deliver such other agreements as may be reasonably
requested by the Company and/or the underwriter(s) which are consistent with the
foregoing or which are necessary to give further effect thereto. In order to
enforce the foregoing covenant, the Company may impose stop-transfer
instructions with respect to your Common Stock until the end of such period.

         (e)  No Transfer. Your option is not transferable, except by will or by
the laws of descent and distribution, and is exercisable during your life only
by you. Notwithstanding the foregoing, by delivering written notice to the
Company, in a form satisfactory to the Company, you may designate a third party
who, in the event of your death, shall thereafter be entitled to exercise your
option.

     9.   Option not a Service Contract. Your option is not an employment or
service contract, and nothing in your option shall be deemed to create in any
way whatsoever any obligation on your part to continue in the employ of the
Company or an Affiliate, or of the Company or an Affiliate to continue your
employment. In addition, nothing in your option shall obligate the Company or an
Affiliate, their respective shareholders, Boards of Directors, Officers or
Employees to continue any relationship that you might have as a Director or
Consultant for the Company or an Affiliate.

     10.  Withholding Obligations.

     (a)  At the time your option is exercised, in whole or in part, or at any
time thereafter as requested by the Company, you hereby authorize withholding
from payroll and any other amounts payable to you, and otherwise agree to make
adequate provision for (including by means of a "same day sale" pursuant to a
program developed under Regulation T as promulgated by the Federal Reserve Board
to the extent permitted by the Company), any sums required to satisfy the
federal, state, local and foreign tax withholding obligations of the Company or
an Affiliate, if any, which arise in connection with your option.

     (b)  Upon your request and subject to approval by the Company, in its sole
discretion, and compliance with any applicable conditions or restrictions of
law, the Company may withhold from fully vested shares of Common Stock otherwise
issuable to you upon the exercise of your option a number of whole shares having
a Fair Market Value, determined by the Company as of the date of exercise, not
in excess of the minimum amount of tax required to be withheld by law. If the
date of determination of any tax withholding obligation is deferred to a date
later than the date of exercise of your option, share withholding pursuant to
the preceding sentence shall not be permitted unless you make a proper and
timely election under Section 83(b) of the Code, covering the aggregate number
of shares of Common Stock acquired upon such exercise with respect to which such
determination is otherwise deferred, to accelerate the determination of such tax
withholding obligation to the date of exercise of your option.

                                       4
<PAGE>

Notwithstanding the filing of such election, shares shall be withheld solely
from fully vested shares of Common Stock determined as of the date of exercise
of your option that are otherwise issuable to you upon such exercise. Any
adverse consequences to you arising in connection with such share withholding
procedure shall be your sole responsibility.

Your option is not exercisable unless the tax withholding obligations of the
Company and/or any Affiliate are satisfied.  Accordingly, you may not be able to
exercise your option when desired even though your option is vested, and the
Company shall have no obligation to issue a certificate for such shares or
release such shares from any escrow provided for herein.

     11.  Notices. Any notices provided for in your option or the Plan shall be
given in writing and shall be deemed effectively given upon receipt or, in the
case of notices delivered by the Company to you, five (5) days after deposit in
the United States mail, postage prepaid, addressed to you at the last address
you provided to the Company.

     12.  Governing Plan Document. Your option is subject to all the provisions
of the Plan, the provisions of which are hereby made a part of your option, and
is further subject to all interpretations, amendments, rules and regulations
which may from time to time be promulgated and adopted pursuant to the Plan. In
the event of any conflict between the provisions of your option and those of the
Plan, the provisions of the Plan shall control.

                                       5

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