Document:

EX-10.43

 Exhibit 10.43 

SECOND AMENDMENT TO CREDIT AGREEMENT 

This SECOND AMENDMENT TO CREDIT AGREEMENT (this “Amendment”) is made and entered into as of June 30, 2015 by and among UNILIFE
MEDICAL SOLUTIONS, INC., a Delaware corporation (the “Borrower”), the other Creditor Obligors party hereto and ROS ACQUISITION OFFSHORE LP, a Cayman Islands exempted limited partnership (the “Lender”). 

WHEREAS, the Borrower and the Lender are party to that certain Credit Agreement, dated as of March 12, 2014 (as amended on
September 30, 2014, and as further amended from time to time, the “Credit Agreement”), pursuant to which the Lender has extended credit to the Borrower on the terms set forth therein; 

WHEREAS, the Borrower has requested that the Lender amend the Credit Agreement, as more fully described herein; and 

WHEREAS, the Lender is willing to agree to such amendment, but only upon the terms and subject to the conditions set forth herein. 

NOW, THEREFORE, in consideration of the mutual agreements herein contained, and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 
 1. Definitions; Loan Document. Capitalized
terms used herein without definition shall have the meanings assigned to such terms in the Credit Agreement. This Amendment shall constitute a Loan Document for all purposes of the Credit Agreement and the other Loan Documents. Each reference to
“hereof”, “hereunder”, “herein” and “hereby” and each other similar reference and each reference to “this Agreement” and each other similar reference contained in the Credit Agreement shall, after
this Amendment becomes effective, refer to the Credit Agreement as amended hereby. 
 2. Amendment. Section 8.4 of the Credit
Agreement is hereby amended by deleting Section 8.4(c) in its entirety. 
 3. Conditions to Effectiveness of Amendment. This
Amendment shall become effective upon receipt by (i) the Lender of a counterpart signature to this Amendment duly executed and delivered by the Borrower and each of the other Credit Obligors and (ii) the Credit Obligors of a counterpart
signature to this Amendment duly executed and delivered by the Lender. 
 4. Expenses. The Borrower agrees to pay on demand all
expenses of the Lender (including, without limitation, the fees and out-of-pocket expenses of Covington & Burling LLP, counsel to the Lender, and of local counsel, if any, who may be retained by or on behalf of the Lender) incurred in
connection with the negotiation, preparation, execution and delivery of this Amendment and all other expenses of the Lender remaining unpaid as of the date hereof. 

 5. Representations and Warranties. The Credit Obligors represent and warrant to the Lender
as follows: 
 (a) After giving effect to this Amendment, the representations and warranties of the Borrower and the Guarantors contained in
the Credit Agreement or any other Loan Document shall, (i) with respect to representations and warranties that contain a materiality qualification, be true and correct in all respects on and as of the date hereof, and (ii) with respect to
representations and warranties that do not contain a materiality qualification, be true and correct in all material respects on and as of the date hereof, and except that the representations and warranties limited by their terms to a specific date
shall be true and correct as of such date. 
 (b) After giving effect to this Amendment, no Default or Event of Default has occurred or is
continuing. 
 (c) (i) Each Credit Obligor has taken all necessary action to authorize the execution, delivery and performance of this
Amendment; (ii) this Amendment has been duly executed and delivered by the Credit Obligors and constitutes each of the Credit Obligors’ legal, valid and binding obligations, enforceable in accordance with its terms (except, in any case, as
such enforceability may be limited by applicable bankruptcy, insolvency, reorganization or similar laws affecting creditors’ rights generally and by principles of equity), and (iii) no authorization or other action by, and no notice to or
filing with, any Governmental Authority or other Person is required for the due execution, delivery or performance by any Credit Obligor of this Amendment. 

6. No Implied Amendment or Waiver. Except as expressly set forth in this Amendment, this Amendment shall not, by implication or
otherwise, limit, impair, constitute a waiver of or otherwise affect any rights or remedies of the Lender under the Credit Agreement or the other Loan Documents, or alter, modify, amend or in any way affect any of the terms, obligations or covenants
contained in the Credit Agreement or the other Loan Documents, all of which shall continue in full force and effect. Nothing in this Amendment shall be construed to imply any willingness on the part of the Lender to agree to or grant any similar or
future amendment, consent or waiver of any of the terms and conditions of the Credit Agreement or the other Loan Documents. 
 7.
Reaffirmation of Security Interests. The Credit Obligors (i) affirm that each of the security interests and liens granted in or pursuant to the Loan Documents are valid and subsisting and (ii) agree that this Amendment shall in no
manner impair or otherwise adversely affect any of the security interests and liens granted in or pursuant to the Loan Documents. 
 8.
Reaffirmation of Guarantee. Each Guarantor (a) acknowledges and consents to all of the terms and conditions of this Amendment, (b) affirms all of its obligations under the Loan Documents and (c) agrees that this Amendment and
all documents executed in connection herewith do not operate to reduce or discharge the Guarantor’s obligations under the Loan Documents. 

  
 -2- 

 9. Waiver and Release. TO INDUCE THE LENDER TO AGREE TO THE TERMS OF THIS AMENDMENT, EACH
CREDIT OBLIGOR REPRESENTS AND WARRANTS THAT AS OF THE DATE HEREOF THERE ARE NO CLAIMS OR OFFSETS AGAINST OR RIGHTS OF RECOUPMENT WITH RESPECT TO OR DEFENSES OR COUNTERCLAIMS TO ITS OBLIGATIONS UNDER THE LOAN DOCUMENTS AND IN ACCORDANCE THEREWITH IT:

 (a) WAIVES ANY AND ALL SUCH CLAIMS, OFFSETS, RIGHTS OF RECOUPMENT, DEFENSES OR COUNTERCLAIMS, WHETHER KNOWN OR UNKNOWN, ARISING PRIOR TO
THE DATE HEREOF; AND 
 (b) RELEASES AND DISCHARGES THE LENDER, ITS AFFILIATES AND ITS AND THEIR OFFICERS, DIRECTORS, EMPLOYEES, AGENTS,
SHAREHOLDERS AND ATTORNEYS (COLLECTIVELY THE “RELEASED PARTIES”) FROM ANY AND ALL OBLIGATIONS, INDEBTEDNESS, LIABILITIES, CLAIMS, RIGHTS, CAUSES OF ACTION OR DEMANDS WHATSOEVER, WHETHER KNOWN OR UNKNOWN, SUSPECTED OR UNSUSPECTED, IN LAW OR
EQUITY, WHICH THE BORROWER EVER HAD, NOW HAS, CLAIMS TO HAVE OR MAY HAVE AGAINST ANY RELEASED PARTY ARISING PRIOR TO THE DATE HEREOF AND FROM OR IN CONNECTION WITH THE LOAN DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED THEREBY. 

10. Counterparts; Governing Law. This Amendment may be executed in any number of counterparts and by different parties hereto on
separate counterparts, each of such when so executed and delivered shall be an original, but all of such counterparts shall together constitute but one and the same agreement. Delivery of an executed counterpart of a signature page of this Amendment
by fax transmission or other electronic mail transmission (e.g., “pdf” or “tif”) shall be effective as delivery of a manually executed counterpart of this Amendment. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED IN
ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK (INCLUDING FOR SUCH PURPOSE SECTIONS 5-1401 AND 5-1402 OF THE GENERAL OBLIGATIONS LAW OF THE STATE OF NEW YORK). 

[Remainder of Page Intentionally Left Blank] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed by their
respective officers thereunto duly authorized as of the day and year first above written. 
  

													
	UNILIFE MEDICAL SOLUTIONS, INC.	 		 	UNILIFE CORPORATION
					
	By:	 	/s/ John C. Ryan	 		 	By:	 	/s/ John C. Ryan
		 	Name:	 	John C. Ryan	 		 		 	Name:	 	John C. Ryan
		 	Title:	 	SVP, GC & Secretary	 		 		 	Title:	 	SVP, GC & Secretary
					
		 		 		 		 	UNILIFE CROSS FARM LLC
						
		 		 		 		 	By:	 	/s/ John C. Ryan
		 		 		 		 		 	Name:	 	John C. Ryan
		 		 		 		 		 	Title:	 	SVP, GC & Secretary

  

					
			
	Executed by Unilife Medical Solutions Pty
Limited in accordance with Section 127 of
the Corporations Act 2001	 		 	
			
	/s/ Alan Shortall	 		 	/s/ John C. Ryan
	Signature of director	 		 	 Signature of director/company secretary
(Please delete as applicable)

			
	Alan Shortall	 		 	John C. Ryan
	Name of director (print)	 		 	 Name of director/company secretary (print)

			
	Executed by Unitract Syringe Pty Ltd
in accordance with Section 127 of
the Corporations Act 2001	 		 	
			
	/s/ Alan Shortall	 		 	/s/ John C. Ryan
	Signature of director	 		 	 Signature of director/company secretary
(Please delete as applicable)

			
	Alan Shortall	 		 	John C. Ryan
	Name of director (print)	 		 	 Name of director/company secretary (print)

  

													
		 		 	 ROS ACQUISITION OFFSHORE, LP

    as the Lender
 By OrbiMed Advisors, LLC,
its investment manager

						
		 		 		 		 	By:	 	/s/ Samuel D. Isaly
		 		 		 		 		 	Name:	 	Samuel D. Isaly
		 		 		 		 		 	Title:	 	Managing Member

 Signature Page to Second Amendment to Credit AgreementEX-10.44

 Exhibit 10.44

EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT
AGREEMENT is made and entered into as of this 10th day of September 2015, by and between Unilife Corporation (“Unilife”) and Dennis P. Pyers (“Pyers”). The term
“Unilife” shall include its subsidiaries, affiliates, assigns and successors in interest under Sections 7, 8, and 13. 
 WHEREAS, Unilife
is engaged in the business of designing, developing, manufacturing and supplying advanced drug delivery systems; 
 WHEREAS, Unilife desires to
continue the employment of Pyers as Senior Vice President, Chief Accounting Officer and Controller under terms substantially similar to the terms of Pyers’ employment when he commenced employment at Unilife in 2010 and under terms substantially
similar to other Executive Officers of Unilife; and 
 WHEREAS, Unilife and Pyers wish to enter into this employment agreement to set forth the terms
of Pyers’ employment relationship with Unilife. 
 NOW, THEREFORE, in consideration of the promises and covenants set forth herein, and
intending to be legally bound hereby, the parties agree as follows: 
 1. Term. This agreement shall be effective as of the date of this agreement
and shall be for a multi-year term commencing on such effective date and expiring on December 31, 2018. This agreement will automatically renew for one-year periods annually thereafter, unless either party gives the other party thirty
(30) days written notice in advance of the relevant expiration date of its intention not to renew the agreement. Upon expiration or earlier termination of this employment relationship, the parties will be relieved of their duties and
obligations under this agreement, except that the rights and obligations of Unilife under Section 6 below shall remain in full force and effect until all appropriate payments have been made to Pyers and the rights and obligations of Pyers set
forth in Sections 7 and 8 below shall remain in full force and effect and shall survive the expiration or termination of this agreement, regardless of the reason(s) for termination. 

2. Position and Duties. 
 (a) Unilife
will employ Pyers as Senior Vice President, Chief Accounting Officer and Controller and Pyers agrees to serve in such capacity for Unilife with responsibility for Unilife’s accounting and control functions and such other duties as are assigned
to him by the Chief Financial Officer (“CFO”) of Unilife, and shall have vested in him the authority and duties typically held by an employee in such position. Pyers shall report to the Chief Financial Officer with respect to the
performance of these duties and shall be a member of the Executive Team. In the performance of these duties, Pyers shall devote his knowledge, skill, attention, energies and all of his business time, and shall comply with all of Unilife’s
policies, rules, and procedures, as they may be amended from time to time. Pyers shall not engage in any endeavor that would conflict with the rendition of his services to Unilife, either directly or indirectly, without the prior written consent of
Unilife’s Chief Executive Officer (“CEO”); provided, however, Pyers may participate in civic, charitable, educational, industry and professional organizations, to the extent that such participation does not unreasonably interfere with
the performance of his duties hereunder; and Pyers may also serve on corporate boards and committees, but only with the prior written consent of Unilife’s CEO. 

(b) Notwithstanding the responsibilities and duties contained in Section 2(a) above, Pyers acknowledges that all material decisions
relating to the management of Unilife’s business will be made by the CEO or the Board of Directors of Unilife. In addition, any decisions which have the capacity to affect significantly the financial standing of Unilife must be referred to the
CFO, CEO or Board of Directors of Unilife who will have ultimate control in respect of these matters. 

  
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 3. Compensation. 

(a) Base Salary. Pyers shall be paid an annual base salary of Three Hundred Thousand Dollars ($300,000) payable in accordance with
Unilife’s standard payroll practices. Pyers’ base salary will be subject to the customary withholding and employment taxes, as required by law, with respect to compensation paid by an employer to an employee. At the discretion of the
Compensation Committee of the Board of Directors of Unilife (the “Compensation Committee”), Pyers shall be eligible for increases in base salary. Further, Unilife will not reduce Pyers’ base salary to less than what is agreed to
herein. 
 (b) Bonus. Pyers shall be eligible to participate in Unilife’s Incentive Bonus Plan in amounts and percentages as
determined by Unilife’s Compensation Committee. The target cash bonus amount for such bonus will be forty percent (40%) of base salary. Bonuses are subject to achievement of such goals and objectives as the Compensation Committee
determines in a set of Key Performance Indicators. Any bonus payable for a fiscal or calendar year shall be paid in a lump-sum payment no later than the date that is two and one-half months after the close of the relevant fiscal or calendar year.
Pyers’ bonuses will be subject to the customary withholding and employment taxes, as required by law, with respect to compensation paid by an employer to an employee. 

4. Benefits. 
 (a) Benefits Generally
Available to Unilife Employees. Pyers shall be eligible to participate in Unilife’s benefits programs (including any equity incentive plan of Unilife or its affiliates), as they may change from time to time. The benefits provided to Pyers
will be the same as the benefits provided to other similarly situated Unilife employees, and may be changed upon expiration or other termination of the current benefits contracts. For further information, Pyers should review any applicable benefit
plan documents, which will govern the terms of the benefits. 
 (b) Vacation. Pyers shall also receive four (4) weeks of paid
vacation per calendar year. Any unused vacation days may be carried over or paid in lieu thereof, to the extent allowed by Unilife’s policy for similarly situated employees or at the CEO’s discretion. 

(c) Equity Plans. Any stock options and other stock-based awards that Pyers may receive from Unilife shall be governed by the
applicable, underlying award agreement and the terms of the 2009 Stock Incentive Plan or any successor plan under which the award is granted. 

(d) Expenses. Unilife shall reimburse Pyers for all reasonable and necessary expenses incurred by him in carrying out his duties under
this agreement in accordance with 

  
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Unilife’s business expense policies, including without limitation, requirements with respect to reporting, documentation and payment of such expenses. All such expenses shall be paid
promptly after submission in accordance with Unilife’s polices, but no later than December 31st of the calendar year following the year in which such expenses were incurred. 

5. Indemnification. Unilife agrees to provide Pyers with indemnification equivalent to that provided to other members of senior management and
insurance coverage pursuant to Unilife’s Directors and Officers insurance policies, as amended from time to time. 
 6. Termination and Pay upon
Termination. 
 (a) General Rule. In the event that Unilife terminates this agreement and Pyers’ employment without Cause as
defined herein, including employment termination due to Unilife’s election not to renew this agreement where Pyers was willing and able to continue performing services under the terms of this agreement, Unilife will pay Pyers the severance
benefits provided in subparagraphs (i) through (iv) of this Section 6(a). 
 (i) his base salary, at the rate
in effect immediately before the date that Pyers’ employment terminates, for twelve (12) months, in accordance with Unilife’s standard payroll practices then in effect, commencing on the fifteenth (15th) day after the date that Pyers’ employment terminates and the General Release provided for in Section 9 of this Agreement becomes irrevocable; 

(ii) provided that Pyers is eligible for and timely elects to receive COBRA health, vision and dental care continuation
coverage, the cost of Pyers’ COBRA health, vision and dental care continuation coverage premiums (for himself and his eligible dependents) for twelve (12) months, commencing on the first of the month immediately after the month which
includes the date that Pyers’ employment terminates and the General Release provided for in Section 9 of this agreement becomes irrevocable; 

(iii) payment of an amount, equal to the greater of the amount of the bonus, if any, earned by and paid to Pyers for the last
completed bonus year prior to the year in which his employment terminates or the target bonus for which Pyers was eligible to earn in the bonus year in which his employment is terminated, which will be payable in equal installments over a twelve
(12) month period, in accordance with Unilife’s standard payroll practices then in effect, commencing on the fifteenth (15th) day after the date that Pyers’ employment
terminates and the General Release provided for in Section 9 of this Agreement becomes irrevocable; and 
 (iv)
notwithstanding anything to the contrary, all of Pyers’ outstanding and unvested options and other stock-based awards shall vest immediately upon such termination of employment without Cause. 

In the event that Pyers terminates this agreement for any reason, including Pyers’ election not to renew the agreement, Pyers shall not receive any
compensation or benefits from the time that he ceases to devote full time and attention to Unilife’s business, except such compensation as was earned prior to that date, including, but not limited to unused vacation and vested equity grants. In
addition, Pyers agrees to provide Unilife with thirty (30) days advance written notice of his intent to terminate his employment, whether during the initial term or any renewal thereof. Upon termination of this agreement, the parties will be
relieved of their duties and obligations, 

  
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except that the rights and obligations of Unilife under this Section 6(a) shall remain in full force and effect until all appropriate payments have been made to Pyers, if applicable, and the
rights and obligations of Pyers set forth in Sections 7 and 8 below shall remain in full force and effect and shall survive the expiration or termination of this agreement, regardless of the reason(s) for termination. Upon termination of this
agreement, Pyers shall not have any further contact with any customers of Unilife on behalf of a competing entity until the expiration of the conditions of Section 8 of this agreement. 

(b) Termination Following a Change in Control. 

(i) Termination Pay. Notwithstanding paragraph (a) immediately above, in the event that Unilife terminates this
agreement and Pyers’ employment without Cause as defined herein, including employment termination due to Unilife’s election not to renew this agreement where Pyers was willing and able to continue performing services under the terms of
this agreement, in either case coincident with or within twelve months after a Change in Control as defined in subparagraph (iii) immediately below, then Unilife, in lieu of and not in duplication of the severance compensation provided for in
paragraph (a) immediately above, shall pay Pyers: 
 (A) his base salary, at the rate in effect immediately before the
date that Pyers’ employment terminates, for eighteen (18) months, in accordance with Unilife’s standard payroll practices then in effect, commencing on the fifteenth (15th) day
after the date that Pyers’ employment terminates and the General Release provided for in Section 9 of this Agreement becomes irrevocable, 

(B) provided that Pyers is eligible for and timely elects to receive COBRA health, vision and dental care continuation
coverage, the cost of Pyers’ COBRA health, vision and dental care continuation coverage premiums (for himself and his eligible dependents) for eighteen (18) months, commencing on with the first of the month immediately after the month
which includes the date that Pyers’ employment terminates and the General Release provided for in Section 9 of this Agreement becomes irrevocable, 

(C) payment of a lump-sum amount, equal to the greater of the amount of the bonus, if any, earned by and paid to Pyers for the
last completed bonus year prior to the year in which his employment terminates or the target bonus for which Pyers was eligible to earn in the bonus year in which his employment is terminated, which will be payable on the fifteenth (15th) day after the date that Pyers’ employment terminates and the General Release provided for in Section 9 of this Agreement becomes irrevocable, and 

(D) notwithstanding anything to the contrary, all of Pyers’ outstanding and unvested options and other stock-based awards
shall vest immediately upon a Change in Control. 
 (ii) Definition of “Cause”. “Cause” will mean
any one or more of the following: 
 (A) material neglect of assigned duties, willful misconduct in connection with the
performance of duties, or refusal to perform assigned duties 

  
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(other than by reason of disability) which continues uncured for thirty (30) days following receipt of written notice of such deficiency from the CEO, specifying the scope and nature of the
deficiency; 
 (B) engaging in any act of dishonesty, any act of moral turpitude, any illegal conduct or committing a crime
that causes material harm to Unilife or its reputation; 
 (C) being barred from working in a Food and Drug Administration
(“FDA”) regulated industry by the FDA or otherwise being sanctioned by the FDA or any similar international body; 

(D) breaching, in any material respect, the terms of any agreement with Unilife; or 

(E) commencement of employment with any other employer while an employee of Unilife without the prior written consent of the
CEO. 
 Any determination of “Cause” as used herein will be made in good faith by the CEO. 

(iii) Definition of “Change in Control”. “Change in Control” means a: (i) Change in Ownership
of Unilife Corporation, (ii) Change in Effective Control of Unilife Corporation, or a (iii) Change in the Ownership of Assets of Unilife Corporation, all as described herein and construed in accordance with section 409A of the Internal
Revenue Code of 1986, as amended (the “Code”). 
 (A) A Change in Ownership of Unilife Corporation shall occur on
the date that any one Person acquires, or Persons Acting as a Group (or Group) acquire, ownership of the capital stock of Unilife Corporation that, together with the stock held by such Person or Group, constitutes more than fifty percent
(50%) of the total fair market value or total voting power of the capital stock of Unilife Corporation. However, if any one Person is, or Persons Acting as a Group are, considered to own more than fifty percent (50%) of the total fair
market value or total voting power of the capital stock of Unilife Corporation, the acquisition of additional stock by the same Person or Persons Acting as a Group is not considered to cause a Change in Ownership of Unilife Corporation or to cause a
Change in Effective Control of Unilife Corporation. An increase in the percentage of capital stock owned by any one Person, or Persons Acting as a Group, as a result of a transaction in which Unilife Corporation acquires its stock in exchange for
property will be treated as an acquisition of stock. 
 (B) A Change in Effective Control of Unilife Corporation shall occur
on the date a majority of members of the Board of Directors of Unilife Corporation is replaced during any twelve (12)-month period by directors whose appointment or election is not endorsed by a majority of the members of the Board of Directors of
Unilife Corporation before the date of the appointment or election. 
 (C) A Change in the Ownership of Assets of Unilife
Corporation shall occur on the date that any one Person acquires, or Persons Acting as a Group acquire (or has or have acquired during the twelve (12)-month period ending on 

  
 Page 5 of 13 

 
the date of the most recent acquisition by such Person or Persons), assets (including tangible/real property and intangible property (such as goodwill)) from Unilife Corporation the total gross
fair market value of which is more than fifty percent (50%) of the total gross fair market value of all of the assets of Unilife Corporation immediately before such acquisition or acquisitions. For this purpose, gross fair market value means
the value of the assets of Unilife Corporation, or the value of the assets being disposed of, determined without regard to any liabilities associated with such assets. 

(D) The following rules of construction apply in interpreting the definition of Change in Control: 

(I) A Person means any individual, entity or group within the meaning of Section 13(d) (3) or 14(d) (2) of the
Securities Exchange Act of 1934, as amended, other than employee benefit plans sponsored or maintained by Unilife Corporation and by entities controlled by Unilife Corporation or an underwriter of the capital stock of Unilife Corporation in a
registered public offering. 
 (II) Persons will be considered to be Persons Acting as a Group if they are owners of a
corporation that enters into a merger, consolidation, purchase or acquisition of stock, or similar business transaction with the corporation. If a Person owns stock in both corporations that enter into a merger, consolidation, purchase or
acquisition of stock, or similar transaction, such shareholder is considered to be acting as a Group with other shareholders only with respect to the ownership in that corporation before the transaction giving rise to the change and not with respect
to the ownership interest in the other corporation. Persons will not be considered to be acting as a Group solely because they purchase assets of the same corporation at the same time or purchase or own stock of the same corporation at the same
time, or as a result of the same public offering. 
 (III) For purposes of this Section 6(b), fair market value shall
be determined in accordance with Code Section 409A. 
 (IV) A Change in Control shall not include a transfer to a
related person as described in Code section 409A or a public offering of capital stock of Unilife Corporation. 
 (E)
For purposes of this Section 6(b), Code section 318(a) applies to determine stock ownership. Stock underlying a vested option is considered owned by the individual who holds the vested option (and the stock underlying an unvested option is not
considered owned by the individual who holds the unvested option). For purposes of the preceding sentence, however, if a vested option is exercisable for stock that is not substantially vested (as defined by Treasury Regulation §1.83-3(b) and
(j)), the stock underlying the option is not treated as owned by the individual who holds the option. 

  
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 7. Confidential Information. 

(a) Pyers acknowledges that Unilife has a valuable property interest in all aspects of its business relationships with its customers, clients,
vendors and suppliers. In the course of Pyers’ work with Unilife, Pyers will become aware of and familiar with secret and confidential information of Unilife relating to its customers, clients, vendors and suppliers, and its internal business
operations. Secret and confidential information includes, but is not limited to, Unilife’s business plans, customer lists, customer data, marketing plans, supplier and vendor lists and cost information, software and computer programs, data
processing systems and information contained therein, financial statements, financial data, acquisition and divestiture plans, and any other trade secrets or confidential or proprietary information, documents, reports, plans, or data, of or about
Unilife that is not already available to the public or was known to Pyers prior to his employment with Unilife. 
 (b) Pyers agrees that he
will not, without the written consent of Unilife, during the term of this agreement or thereafter, disclose or make any use of secret and confidential information, except as may be required in the performance of his duties under Section 2 of
this agreement. Pyers agrees that, following the termination of his employment with Unilife for any reason, he will never use secret and confidential information to compete with Unilife in any manner, and he will never disclose any secret and
confidential information to any other business or individual, unless such secret or confidential information is: (i) publicly known through no breach of the provisions of this Section 7 by either party, (ii) lawfully disclosed by a
third party, or (iii) disclosed pursuant to legal requirement or court order. In no event shall any disclosure made to investment banking firms or private equity firms at the request of Unilife and as part of Pyers’ duties ever be
considered a violation of this Section 7. 
 (c) Upon termination of this agreement, Pyers shall surrender to Unilife all records and
all paper and/or electronic copies made of those records that pertain to any aspect of the business of Unilife, including all secret and confidential information. 

8. Agreement Not To Compete. 
 (a) In
consideration for employment by Unilife and the benefits of this agreement, Pyers agrees to be bound by the covenant not to compete as set forth in Section 8 of this agreement below; provided however, this non-compete covenant will extend for a
period of two (2) years post-employment, if Pyers resigns his employment with Unilife or if Unilife terminates Pyers’ employment for Cause, and provided further that this non-compete covenant will extend for a period of one (1) year
post-employment if Pyers’ employment with Unilife is terminated by Unilife for any reason, other than Cause. 
 (b) Pyers agrees that
during the term of his employment he will not, directly or indirectly: 
 (i) render services to, become employed by, be
engaged as a consultant by, own, or have a financial or other interest in (either as an individual, partner, joint venture, owner, manager, employee, partner, officer, director, independent contractor, or other similar role) any business that is
engaged in any business activity that is in direct competition with the activities of Unilife, as of the date of the termination of this agreement. 

(ii) induce, offer, assist, encourage, or suggest that another business or enterprise offer employment to or enter into a
consulting arrangement with any individual who is employed by Unilife, or induce, offer, assist, encourage, or suggest that any Unilife employee terminate his or her employment with Unilife, or accept employment with any other business or
enterprise. 

  
 Page 7 of 13 

 (c) In the event that Pyers commits any breach of Section 8(b) above, Pyers acknowledges
that Unilife would suffer substantial and irreparable harm and damages. Accordingly, Pyers hereby agrees that in such event, Unilife shall be entitled to temporary and/or permanent injunctive relief, without the necessity of proving damage, to
enforce the provisions of this Section, all without prejudice to any and all other remedies that Unilife may have at law or in equity and that Unilife may elect or invoke. Pyers agrees that if any of the provisions of this Section are or become
unenforceable, the remainder hereof shall nevertheless remain binding upon him to the fullest extent possible, taking into consideration the purposes and spirit of this agreement. Any invalid or unenforceable provision is to be reformed to the
maximum time, geographic and/or business limitations permitted by applicable laws, so as to be valid and enforceable. 
 (d) Pyers expressly
acknowledges and agrees that the restrictive covenants set forth in Sections 7 and 8 above are absolutely necessary to protect the legitimate business interests of Unilife, because he is employed in a position of trust and confidence and is provided
with extensive access to Unilife’s most confidential and proprietary trade secrets, and has significant involvement in important business relationships, which constitute the goodwill of Unilife. Pyers further agrees and acknowledges that these
restrictive covenants are reasonable, will not restrict him from earning a livelihood following the termination of employment, and are intended by the parties to be enforceable following termination of employment for any reason. 

(e) In the event that Unilife must bring legal action to enforce or seek a remedy for any breach of the provisions of Sections 7 or 8 of this
agreement and Pyers is found by a court to have breached any of these provisions, Pyers agrees to reimburse Unilife for any and all expenses, including attorneys’ fees and court costs, incurred by it in enforcing the terms of these Sections of
the agreement. 
 9. General Release. As a condition of receiving the severance compensation and benefits described in Section 6, Unilife and
Pyers will execute a mutual general release of claims (which is in a form acceptable to Unilife); provided that, to the extent that any claim that Unilife may have against Pyers would not be covered under the D&O insurance of Unilife, then
Unilife would not release such claim under the mutual release. Such general release would not include rights to previously vested options or claims for any compensation or benefits earned (including, without limitation, unused vacation), or
reimbursement of expenses incurred, through the date of termination. Such release must be agreed to, executed and irrevocable no later than 30 days following Pyers’ termination date. 

10. Dispute Resolution. Any controversy, claim or dispute involving the parties (or their affiliated persons) directly or indirectly concerning this
agreement shall be finally settled by binding arbitration held in Montgomery County, Pennsylvania by one arbitrator (who is mutually acceptable to both parties as well as licensed to practice law in the Commonwealth of Pennsylvania) in accordance
with the rules of employment arbitration then followed by the American Arbitration Association or any successor to the functions thereof. The arbitrator shall apply Pennsylvania law in the resolution of all controversies, claims and disputes and
shall have 

  
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the right and authority to determine how his or her decision or determination as to each issue or matter in dispute may be implemented or enforced. Any decision or award of the arbitrator shall
be final and conclusive for both Pyers and Unilife (and its affiliates), and there shall be no appeal there from other than causes of appeal allowed by the Federal Arbitration Act. Unilife shall bear all costs of the arbitrator in any action brought
under this agreement. The arbitrator shall have the power to award attorney’s fees and arbitration costs to the prevailing party, if the award of attorney’s fees and litigation costs would be permitted by a court. The parties hereto agree
that any action to compel arbitration may be brought in the appropriate Pennsylvania state or federal court, and in connection with such action to compel, the laws of the Commonwealth of Pennsylvania and the Federal Arbitration Act shall control.
Application may also be made to such court for confirmation of any decision or award of the arbitrator, for an order of the enforcement and for any other remedies, which may be necessary to effectuate such decision or award. The parties hereto
hereby consent to the jurisdiction of the arbitrator and of such court and waive any objection to the jurisdiction of such arbitrator and court. 
 11.
Non-waiver. A waiver of any provision of this agreement by either party shall not prevent either party from enforcing that provision or any other provision hereof. 

12. Assignment. This agreement is personal and may not be assigned by Pyers. Any assignment of this agreement between Unilife (or its successor) and
its affiliates (and their successors) shall not constitute a termination of Pyers’ employment hereunder. This agreement (including the Restrictive Covenants set forth in Sections 7 and 8) shall inure to the benefit of and be binding upon any
successor to Unilife. The parties specifically understand and agree that the non-compete provisions of Section 8 will inure to the benefit of a successor and that Pyers will remain bound by these provisions in the event of a sale or corporate
reorganization of Unilife. 
 13. Severability. Each provision of this agreement is severable and distinct from, and independent of, every other
provision hereof. If one provision hereof is declared void, the remaining provisions shall remain in effect. Any provision of this agreement which is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective only
to the extent of such prohibition or unenforceability without invalidating or affecting the remaining provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in
any other jurisdiction. 
 14. Entire Agreement. This agreement contains the entire agreement of the parties concerning the employment relationship
and supersedes any prior agreements or understandings between the parties concerning the terms and conditions of Pyers’ employment, whether oral or written; provided, however, that Pyers’ equity grants shall be governed by the equity grant
documents; provided further, that any stock options or other stock-based awards provided to Pyers shall be governed by Unilife’s stock incentive plans as they are amended from time to time, except as provided herein. The parties acknowledge, in
entering into this agreement that they have not relied upon any promise or inducement not specifically set forth herein. Any changes to this agreement must be in writing and signed by both parties. 

15. Section 409A. 
 (a) This
agreement is intended to comply with, or otherwise be exempt from, Code section 409A and any regulations and Treasury guidance promulgated thereunder, and Unilife shall be required to interpret the terms of this agreement as necessary to comply
with the requirements of Code section 409A. 

  
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 (b) Unilife shall undertake to administer, interpret, and construe this agreement in a manner
that does not result in the imposition on Pyers of any additional tax, penalty, or interest under Code section 409A. 
 (c) Unilife and
Pyers agree that they will execute any and all amendments to this agreement permitted under applicable law as they mutually agree in good faith may be necessary to ensure compliance with the distribution provisions of Code section 409A or as
otherwise needed to ensure that this agreement complies with that section. 
 (d) The preceding provisions, however, shall not be construed
as a guarantee by Unilife of any particular tax effect to Pyers under this agreement. Unilife shall not be liable to Pyers for any payment made under this agreement that is determined to result in an additional tax, penalty, or interest under Code
section 409A, nor for reporting in good faith any payment made under this agreement as an amount includible in gross income under that section. 

(e) For purposes of Code section 409A, the right to a series of installment payments under this agreement shall be treated as a right to a
series of separate payments. 
 (f) With respect to any reimbursement of future expenses of, or any provision of in-kind benefits to, Pyers,
as specified under this agreement, such reimbursement of expenses or provision of in-kind benefits shall be subject to the following conditions: (i) the expenses eligible for reimbursement or the amount of in-kind benefits provided in one
taxable year shall not affect the expenses eligible for reimbursement or the amount of in-kind benefits provided in any other taxable year, except for any medical reimbursement arrangement providing for the reimbursement of expenses referred to in
Code section 105(b); (ii) the reimbursement of an eligible expense shall be made no later than the end of the year after the year in which such expense was incurred; and (iii) the right to reimbursement or in-kind benefits shall not be
subject to liquidation or exchange for another benefit. Any tax gross-up payment shall be made by no later than the end of the calendar year following the year in which Pyers remits the taxes. 

(g) “Termination of employment,” “resignation,” or words of similar import, as used in this agreement means, for purposes
of any payments under this agreement that are payments of deferred compensation subject to Code section 409A, Pyers‘ “separation from service” as defined in that section. 

(h) If a payment obligation under this agreement arises on account of Pyers’ separation from service while Pyers is a “specified
employee” (as defined under Code section 409A and determined in good faith by the Unilife), any payment of “deferred compensation” (as defined under Treasury regulation section 1.409A-1(b)(1), after giving effect to the exemptions in
Treasury regulation sections 1.409A-1(b)(3) through (b)(12)) that is scheduled to be paid within six (6) months after such separation from service shall accrue without interest and shall be paid within 15 days after the end of the six-month
period beginning on the date of such separation from service or, if earlier, within 15 days after the appointment of the personal representative or executor of Pyers’ estate following his death. 

(i) To the extent that under the terms of the agreement the execution of a general release of claims is a condition to Pyers receiving
severance or other benefits under the 

  
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agreement, the Company will provide Pyers with the form of release agreement within seven days after Pyers’ separation from service. To be entitled to the severance or other benefits, Pyers
must execute and deliver to the Company the release agreement on or before the last day of the minimum required waiver consideration period provided under the Age Discrimination in Employment Act or other applicable law or such other date as may be
specified in the release agreement. If Pyers timely delivers an executed release agreement to the Company, and Pyers does not revoke the release agreement during the minimum revocation period required under applicable law, if any, the severance or
other benefits shall be paid or commence being paid, as applicable, on or after the date on which the release agreement becomes effective as specified in the agreement. If, however, the period during which Pyers has discretion to execute or revoke
the release agreement straddles two calendar years, no such payment shall be made or benefit provided earlier than the first day of the second such calendar year, regardless of within which calendar year Pyers actually delivers the executed release
agreement to the Company. Consistent with Section 409A, Pyers may not, directly or indirectly, designate the calendar year of payment. 
 16. Excise
Tax on Parachute Payments. Pyers shall bear all expense of, and be solely responsible for, all federal, state, local or foreign taxes due with respect to any payment received hereunder, including, without limitation, any excise tax imposed by
Code section 4999. Notwithstanding the foregoing, if any payment or distribution by Unilife to or for the benefit of Pyers, whether paid or payable or distributed or distributable pursuant to the terms of this Agreement or otherwise pursuant to or
by reason of any other agreement, policy, plan, program or arrangement or the lapse or termination of any restriction on or the vesting or exercisability of any payment or benefit, would be subject to the excise tax imposed by Section 4999 of
the Code (or any successor provision thereto) or to any similar tax imposed by state or local law (such tax or taxes are hereafter collectively referred to as the “Excise Tax”), then the aggregate amount of such payments and
benefits (each such payment or benefit, a “Payment”) payable to Pyers shall be reduced to the aggregate amount of Payments that may be made to Pyers without incurring an Excise Tax in accordance with the immediately following
sentence; provided that such reduction shall only be imposed if the net after-tax benefit of the Payments retained by Pyers (after giving effect to such reduction) is equal to or greater than the net after-tax benefit (after giving effect to the
Excise Tax) of the Payments to Pyers without any such reduction. If the Firm (as defined below) determines that a reduction is required by this Section 16, then such reduction shall be made in the following order: (i) first, any future
cash payments (if any) shall be reduced (if necessary, to zero); (ii) second, any current cash payments shall be reduced (if necessary, to zero); (iii) third, all non-cash payments (other than equity or equity derivative related payments)
shall be reduced (if necessary, to zero); and (iv) fourth, all equity or equity derivative payments shall be reduced. 
 For purposes
of this Section 16, “net after-tax benefit” shall mean (i) the total of all Payments which Pyers receives or is then entitled to receive from Unilife, less (ii) the amount of all federal, state, local and foreign income
taxes payable with respect to such Payment calculated at the maximum marginal income tax rate for each year in which the foregoing shall be paid to Pyers (based on the rate in effect for such year as set forth in the Code or other applicable tax law
as in effect at the time of the first payment of the foregoing), less (iii) the amount of the applicable Excise Tax, if any, imposed with respect to the Payment. 

The foregoing determination shall be made by a nationally recognized human resources consulting or accounting firm (the “Firm”)
selected by Unilife and reasonably acceptable to Pyers (which may be, but will not be required to be, Unilife’s independent auditors). The Firm 

  
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shall submit its determination and detailed supporting calculations to both Pyers and Unilife within fifteen (15) days after receipt of a notice from either Unilife or Pyers that Pyers may
receive Payments If the Firm determines that none of the Total Payments, after taking into account any reduction required by this Section 16, constitutes a “parachute payment” within the meaning of Code section 280G, it will, at
the same time as it makes such determination, furnish Pyers and Unilife an opinion that Pyers has substantial authority not to report any excise tax under Code section 4999 on his federal income tax return. 

Pyers and Unilife shall each provide the Firm access to and copies of any books, records, and documents in the possession of Pyers or Unilife,
as the case may be, reasonably requested by the Firm, and otherwise cooperate with the Firm in connection with the preparation and issuance of the determinations and calculations contemplated by this Section 16. The fees and expenses of the
Firm for its services in connection with the determinations and calculations contemplated by this Section 16 shall be borne by Unilife. 
 17.
Counterparts. This agreement may be executed on separate counterparts, each of which is deemed to be an original and all of which taken together constitute one and the same agreement. 

18. Interpretation. The captions and headings of this agreement are not part of the provisions hereof and shall have no force or effect. 

19. Notices. Any notices, requests, demands and other communications provided for by this agreement shall be sufficient if in writing and if hand
delivered, sent by overnight courier, or sent by registered or certified mail to Pyers at the last address he has filed in writing with Unilife or, in the case of Unilife, to Unilife’s CEO at Unilife’s principal executive offices. 

20. Governing Law. The terms of this agreement shall be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania
without giving effect to provisions thereof regarding conflict of laws. 
 21. Representations and Warranties. Pyers represents and warrants to
Unilife that he is not bound by any restrictive covenants and has no prior or other obligations or commitments of any kind that would in any way prevent, restrict, hinder or interfere with Pyers’ acceptance of employment or the performance of
all duties and services hereunder to the fullest extent of Pyers’ ability and knowledge, except for the duty of confidentiality owed to former employers. If Pyers has misrepresented the representation and warranty provided herein, then Pyers
would be liable to Unilife for all damages incurred as a consequence thereof, including attorney’s fees and costs of court. 

[Remainder of the page left blank] 

  
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 IN WITNESS WHEREOF, and wishing to be legally bound, the parties have executed this agreement as of the date
first above written. 
  

							
	UNILIFE CORPORATION:	 		 	Dennis P. Pyers:
				
	By:	 	 /s/ Alan D. Shortall
	 		 	 /s/ Dennis P. Pyers

		 	Alan D. Shortall	 		 	
		 	Chief Executive Officer	 		 	

  
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