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Exhibit 10.15    
    

SUCCESSION AGREEMENT  

        This Succession Agreement (this "Agreement") is made and entered into this 31st day of December, 2005 by and among Cartesian Medical Group, Inc. (the
"Medical Group"), Bashar Dabbas, M.D., ("Physician") and Genoptix, Inc. d/b/a Genoptix Clinical Laboratory("Genoptix"). 

        This
Agreement is made with reference to the following facts: 

        A.    The
Medical Group is a professional medical corporation within the meaning of the Moscone-Knox Professional Corporation Act. 

        B.    The
Medical Group has authorized stock consisting of 100 shares ("Shares"). All Shares have been issued by the Medical Group and are currently outstanding. 

        C.    Physician
is currently the legal and beneficial owner of the Medical Group Shares (the "Sole Shareholder") and is currently the Medical Director (the "Medical Director")
of Genoptix pursuant to an Agreement for Medical Director of Genoptix of even date herewith between Physician and Genoptix (the "Director Agreement"). 

        D.    The
parties hereto desire to promote their mutual interests by imposing certain restrictions on the sale, transfer or other disposition of the Shares and provide for
certain disposition of the Shares in the event of the death, permanent disability, permanent incapacity or termination of the Director Agreement thus ensuring the continued successful operation of the
business of the Medical Group through continuous harmonious management and Share ownership. 

        E.    Further,
the parties hereto desire to set forth certain of their understandings with reference to other matters pertaining to the Medical Group. 

        F.     The
Medical Group is entering into a Professional Services Agreement (the "PSA") of even date herewith with Genoptix. The parties hereto acknowledge that but for the
execution of this Agreement, Genoptix would not enter into the PSA. 

        G.    Each
of the parties has agreed to be bound by the covenants and agreements set forth herein, all of which are for the mutual benefit of the parties hereto, collectively
and individually. 

        NOW
THEREFORE, the parties hereto hereby agree as follows: 

        1.    GENERAL PURPOSE.    

        The
purpose of this Agreement is to provide for the ownership of the Shares of the Medical Group upon the occurrence of the events set forth below (collectively, "Succession Events"). In
connection therewith, it is the intent of the parties hereto that the Medical Group maintain its existence as a professional medical corporation and continue to honor the terms of the PSA. 

        The
Sole Shareholder (or his or her estate) shall transfer all Shares pursuant to Section 3 below, upon the occurrence of any one or more of the following Succession Events: 

        A.    if
the Sole Shareholder dies; 

        B.    if
the Sole Shareholder is determined by Genoptix, in its sole and exclusive discretion, to be incompetent, or is permanently disabled so as to be unable to render any
professional services on behalf of the Medical Group; 

        C.    if
any of the shares held by the Sole Shareholder are transferred voluntarily, involuntarily or by operation of law to a person who is not Medical Director; 

        D.    if
Sole Shareholder ceases to be duly licensed to practice medicine under the laws of the State of California or ceases to be in good standing with the Medical Board of
California; or 

 

        E.    if
the Sole Shareholder ceases to be the Medical Director for any reason under the terms of the Director Agreement. 

        2.    EVENTS PRIOR TO SUCCESSION EVENTS.    

        A.    Transfer Restrictions.    No disposition, sale, convenience, assignment, pledge, hypothecation or other transfer
of all or any part of the Shares of the Medical Group, whether voluntarily, involuntarily, by operation of law or otherwise, shall be made by the Sole Shareholder, or by any heir, executor, legal
representative, devisee, testamentary beneficiary, trustee in bankruptcy, successor or assign of the Sole Shareholder, other than in accordance with Section 3 hereof. 

        B.    Stock Certificates.    Each outstanding stock certificate of the Medical Group shall bear the following
endorsement in bold print: 

"The
shares of stock represented by this certificate and the transfer thereof are subject to certain restrictions imposed by a Succession Agreement of the corporation, copies of which will be
furnished by the corporation to the holder hereof upon written request and without charge." 

        3.    EVENT OF SUCCESSION.    

                Transfer to New Sole Shareholder.    Upon the occurrence of a Succession Event:
(1) the then Sole Shareholder shall be disqualified to serve, pursuant to the Bylaws of the Medical Group, as a Director and Officer of the Medical Group; and (2) the then Sole
Shareholder shall immediately transfer, or be deemed to have transferred, all and not less than all of the Shares in the Medical Group held by the then Sole Shareholder to such Sole Shareholder's
successor as Medical Director, or other position as dictated by Genoptix, whether said successor is appointed in an acting, interim or permanent capacity. The successor shall, immediately, upon such
transfer, or deemed transfer, become the successor Sole Shareholder, Director, President and Treasurer of the Medical Group. The consideration for the above described transfer shall be an amount equal
to the stated par value of the transferred shares on the date of the Transfer Event. 

        4.    COMMUNITY PROPERTY INTEREST.    The Physician hereto agrees that he shall cause his spouse to execute a
Statement of Spouse (in the form of that attached hereto as Exhibit "A") signifying such spouse's consent to this Agreement and such spouse's agreement that any rights that spouse may have, as a
result of a community property interest in the Shares or otherwise, shall be subject to the provisions of this Agreement. It is intended by this Agreement that the Physician shall subject his entire
interest in the Shares owned by him to the terms of this Agreement, irrespective of any community property interest of his spouse. 

        5.    DELIVERY OF SHARES, STOCK ASSIGNMENTS.    Upon the purchase or transfer of any Shares hereunder, the Medical
Group or the person selling or transferring the Shares shall deliver to the Medical Group and/or the purchasing Sole Shareholder, as the case may be, the stock certificate or certificate evidencing
the Shares purchased, together with all necessary or appropriate stock assignments separate from certificate. 

        6.    FURTHER AGREEMENT.    Any successor Sole Shareholder shall become a party to this Agreement and agree to be
bound by the terms hereof. 

        7.    COPY OF AGREEMENT.    The Medical Group shall keep a copy of this Agreement on file in the principal business
office of the Medical Group. 

        8.    NOTICES.    Any and all notices or other matters required or permitted by this Agreement to be served on, given
to or delivered to a party shall be in writing and shall be deemed duly served, given or delivered when personally delivered to such party, or in lieu of such personal service, when 

2

 

deposited
in the United States mail, certified, postage prepaid, or by facsimile transmission followed by mail delivery, addressed to such person as follows: 

	To: "Medical Group"	 	Cartesian Medical Group, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121

Attention: Bashar Dabbas, M.D.,
	

To: "Genoptix"	
 	

Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, California 92121

Attention: Douglas A. Schuling, Chief Financial Officer
	

To: "Physician"	
 	

Bashar Dabbas, M.D.

3398 Carmel Mountain Road

San Diego, California 92121

        Any
party hereto may change its address for the purpose of receiving notices, demands and other communications as herein provided by a written notice given in the manner aforesaid to the
other parties hereto. 

        9.    MISCELLANEOUS.    

        9.1    Applicable Law.    This Agreement shall, in all respects, be governed by the laws of the State of California
applicable to Agreements executed and to be performed in California. 

        9.2    Severability.    Nothing contained herein shall be construed so as to require the commission of any act
contrary to law, and wherever there is any conflict between any provisions contained herein and any present or future statute, law, ordinance or regulation, the latter shall prevail; but the provision
of this Agreement which is affected shall be curtailed and limited only to the extent necessary to bring it into the requirements of the law. 

        9.3    Further Assurances.    Each of the parties hereto shall execute and deliver any and all additional papers,
documents, and other assurances, and shall do any and all acts and things reasonably necessary in connection with the performance of his or her obligations hereunder to carry out the intent of the
parties hereto. 

        9.4    Modification or Amendments.    No amendment, change or modification of this Agreement shall be valid, unless in
writing and signed by all of the parties hereto. 

        9.5    Entire Agreement.    This Agreement constitutes the entire understanding and agreement of the parties with
respect to its subject matter and any and all prior Agreement, understandings or representations with respect to its subject matter are hereby terminated and canceled in their entirety and are of no
further force or effect. 

        9.6    Non-Waiver.    No Waiver by any party hereto for a breach of any provision of this Agreement shall
constitute a waiver of any preceding or succeeding breach of the same or any other provision hereof. 

        9.7    Counterparts.    This Agreement may be executed in one or more counterparts, each of which shall be deemed an
original, but all of which together shall constitute one and the same instrument. 

        9.8    Number and Gender.    In this Agreement, the masculine, feminine or neuter gender, and the singular or plural
number, shall each be deemed to include the other, whenever the context so requires. 

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        9.9    Captions.    The Captions appearing at the commencement of the sections hereof are descriptive only and for
convenience in reference. Should there be any conflict between any such caption and the section at the head of which it appears, the section and not such caption shall control and govern in the
construction of this Agreement. 

        IN
WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date and year first above written. 

	 	 	GENOPTIX, INC.
	

 	
 	
By:	

/s/  TINA S. NOVA      
 Tina S. Nova, Ph.D., President & CEO
	

 	
 	
CARTESIAN MEDICAL GROUP, INC.
	

 	
 	
By:	

/s/  DOUGLAS A. SCHULING      
 Douglas A. Schuling, Secretary
	

 	
 	

Physician
	

 	
 	

/s/  BASHAR DABBAS      
 Bashar Dabbas, M.D.

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Exhibit 10.16    
    

MEDICAL DIRECTOR AGREEMENT  

        This Medical Director Agreement ("Agreement") is entered into this 31st day of December, 2005, by and between Genoptix, Inc. ("Genoptix") and Bashar
Dabbas, M.D. ("Physician"). 

 
 

RECITALS    
    

        A.    Genoptix
is a California corporation that operates a licensed clinical laboratory located at 3398 Carmel Mountain Road, San Diego, CA 92121 (the "Laboratory"). 

        B.    Physician
is (1) an individual licensed to practice medicine in the State of California with at least one year of laboratory training during medical residency,
(2) an individual licensed to practice medicine in the State of California who is certified, or is eligible for certification, in anatomic and/or clinical pathology by the American Board of
Pathology, or (3) an individual licensed to practice medicine in the State of California with at least two years' experience directing or supervising the provision of laboratory tests of the
same level of complexity as those provided by the Laboratory. 

        C.    Genoptix
believes that high standards of clinical laboratory services can be achieved if Physician assumes the responsibilities set forth in this Agreement. 

        D.    Physician
is qualified and desires to provide the services described in this Agreement. 

        NOW,
THEREFORE, in consideration of the above recitals, the terms and conditions hereinafter set forth, and other good and valuable consideration, the receipt and sufficiency of which
are hereby acknowledged, and for their mutual reliance, the parties hereto agree: 

Section 1.    Physician Responsibilities    

        1.1    Medical Director/Administrative Services.    Physician shall act as Medical Director of the Laboratory and, in
this role, he shall provide to Genoptix those services set forth on Exhibit A. 

        1.2    Absences.    Physician shall designate, subject to Genoptix's approval, a qualified replacement, in the event
of Physician's vacation or other temporary approved absence. The person who provides services on behalf of Physician in Physician's absence shall have at least two years experience directing or
supervising the provision of laboratory tests of the same level of complexity as those provided by the Laboratory and bound by all terms of this Agreement. Genoptix shall have the right to approve the
length of Physician's absence, and any unapproved absence shall constitute a breach of this Agreement. 

        1.3    Availability.    At all times the Laboratory is open to provide laboratory services, Physician, or Physician's
qualified replacement, shall be accessible to the Laboratory to provide, onsite, telephone or electronic consultation as needed. Physician shall inform Genoptix, on a monthly basis, of Physician's
schedule and availability to provide services pursuant to this Agreement. 

        1.4    Time Commitment.    Physician shall devote a minimum of twelve (12) hours per month providing the
services described in this Agreement. 

        1.5    Limitation on Use of Space.    No part of Genoptix's premises, including the Laboratory, shall be used at any
time as an office for the private practice of medicine or to analyze patient specimens other than Genoptix patient specimens. 

Section 2.    Genoptix Responsibilities    

        2.1    Genoptix Services.    

        (a)    Space and Equipment.    Genoptix shall furnish the premises for
the Laboratory and such equipment as may be reasonably necessary for the proper operation and conduct of the Laboratory. Genoptix shall repair, replace or supplement such equipment and otherwise
maintain it in good working order. 

 

        2.2    General Services.    Genoptix shall furnish ordinary janitorial services, maintenance services, and utilities,
including telephone service, as may be required for the proper operation and conduct of the space that it provides under this Agreement. 

        2.3    Supplies.    Genoptix shall purchase, through its appropriate departments, all supplies as may be reasonably
required for the proper operation of the Laboratory under this Agreement. 

        2.4    Genoptix Performance.    The responsibilities of Genoptix shall be subject to Genoptix' discretion and its
usual purchasing practices, budget limitations and applicable laws and regulations. 

Section 3.    Compensation    

        3.1    Compensation.    On or before the fifteenth (15th) day of each calendar month during the term of this
Agreement, beginning with the second such month, and on or before the fifteenth (15th) day of the calendar month following the expiration or earlier termination of this Agreement, Genoptix shall pay
Physician Two Thousand Dollars ($2,000) per month for the provision of medical-administrative services provided to Genoptix by Physician under this Agreement during the preceding month. Physician's
compensation for any partial calendar month during the terms of this Agreement shall be prorated based on the actual days this Agreement is in effect during such partial calendar month. 

Section 4.    Term and Termination    

        4.1    Term.    The term of this Agreement shall be for a period of three (3) years beginning on
January 1, 2006 (the "Initial Term"), unless terminated sooner pursuant to the terms and provision of this Agreement. Assuming that neither party is in default hereunder, this Agreement shall
be automatically renewed upon the same terms and conditions set forth herein for successive one (1) year terms (the
"Renewal Term(s)"), unless terminated sooner pursuant to the provisions of this Agreement, or unless either party gives sixty (60) days' prior written notice. The terms and conditions of this
Agreement, including any amendments thereto, shall govern during the Initial Term and each Renewal Term. 

        4.2    Termination.    Notwithstanding the provisions of Section 4.1, this Agreement may be terminated:

        (a)   By
Genoptix at any time, without cause or penalty, upon sixty (60) days' prior written notice to the other party; 

        (b)   Immediately
by Genoptix in its sole discretion if Physician fails to maintain the professional standards described in Section 5.1 of this Agreement; 

        (c)   If
(i) either party determines that any legislation, regulation, rule or procedures are duly passed, adopted or implemented by a federal, state or local
government or legislative body or any private agency; or (ii) either party or any of their affiliates, receives notice of any actual or threatened decision, finding, or action by any
governmental or private agency, court or third party (collectively referred to herein as an "Action") which, if or when implemented, would have the effect of (1) revoking or jeopardizing the
status of the clinical laboratory license granted to Genoptix or any of Genoptix' affiliates or (2) subjecting the parties or any of their respective affiliates, employees, officers, directors
or agents to civil, criminal or administrative prosecution, or other adverse proceeding on the basis of their participation herein; then the parties hereto shall attempt to amend this Agreement or
alter its operation in order to avoid the Action. If, in the opinion of either party, such amendment or alteration is not possible, this Agreement shall be terminated upon the written notice of either
party; 

        (d)   By
either party in the event of a material breach, and in such event, the non-breaching party shall have the right to terminate this Agreement after
providing thirty (30) days' written 

2

 

notice
to the breaching party, unless such breach is cured to the satisfaction of the non-breaching party within the thirty (30) days; 

        (e)   Immediately
by Genoptix upon the death of Physician; 

        (f)    Immediately
by Genoptix if the Physician is determined by Genoptix, in its sole and exclusive discretion, to be incompetent, or is permanently disabled so as to be
unable to render services under the terms of this Agreement; 

        (g)   Immediately
by Genoptix if Physician ceases to be duly licensed to practice medicine under the laws of the State of California or ceases to be in good standing with the
Medical Board of California; or 

        (h)   Immediately
by Genoptix if any of Physician's shares in Cartesian Medical Group, Inc. are transferred voluntarily, involuntarily or by operation of law. 

        4.3    Rights Upon Termination.    Upon any termination or expiration of this Agreement, all rights and obligations of
the parties shall cease except those rights and obligations which have accrued or expressly survive termination. 

Section 5.    Professional Standards    

        5.1    Licensure and Standards.    Physician shall: 

        (a)   At
all times be licensed to practice medicine in the State of California; 

        (b)   At
all times be certified by the American Board of Pathology; 

        (c)   Comply
with all policies, rules and regulations of Genoptix; 

        (d)   Maintain
professional liability coverage in an amount and form acceptable to Genoptix; and 

        (e)   Participate
in continuing education as necessary to maintain licensure, certification and the current standard of practice. 

Section 6.    Relationship Between the Parties    

        6.1    Independent Contractor.    In the performance of this Agreement, it is mutually understood and agreed that
Genoptix and Physician are at all times acting and performing as independent contractors and as such they shall remain professionally and economically independent of each other. Genoptix and
Physician are not and no act, or failure to act by either party hereto, shall be construed to make or render the other' party its partner, joint venturer, employee or associate. Neither Physician nor
Physician employees shall have a claim under this Agreement or otherwise against Genoptix for workers' compensation, unemployment compensation, sick leave, vacation pay, pension or retirement
benefits, social security benefits, any other employee benefits, coverage for health, accident, disability or life insurance or payment of any federal, state or local taxes, including but not limited
to, FICA, FUTA and SDI, all of which shall be the sole responsibility of Physician. Physician shall indemnify and hold harmless Genoptix from any and all loss or liability, if any, arising out of or
with respect to any of the foregoing benefits or withholding requirements. 

        6.2    Indemnification.    Each party shall indemnify, defend and hold harmless the other party from any and all
liability, loss, claim, lawsuit, injury, cost, damage or expense whatsoever (including reasonable attorneys' fees and court costs) arising out of, incident to or in any manner occasioned by the
performance or nonperformance of any duty or responsibility under this Agreement by such indemnifying party, or any of its employees, agents, contractors or subcontractors; provided, however, that
neither party shall be liable to the other party hereunder for any claim covered by insurance, except to the extent that the liability of such party exceeds the amount of such insurance coverage. 

3

 

Section 7.    General Provisions    

        7.1    Access to Records.    To the extent required by Section 1861(v)(1)(I) of the Social Security Act,
as amended, and by valid regulation which is directly applicable to that Section, Physician agrees to make available upon valid written request from the Secretary of HHS, the Comptroller General, or
any other duly authorized representatives, this Agreement and the books, documents and records of Physician to the extent that such books, documents and records are necessary to certify the nature and
extent of Genoptix' costs for services provided by Physician. 

        Physician
shall also make available such subcontract and the books, documents, and records of any subcontractor if that subcontractor performs any of the Physician's duties under this
Agreement at a cost of $10,000 or more over a twelve-month period, and if that subcontractor is organizationally related to Physician. 

        Such
books, documents, and records shall be preserved and available for four (4) years after the furnishing of services by Physician pursuant to this Agreement. If Physician is
requested to disclose books, documents or records pursuant to this subsection for purposes of an audit, Physician shall notify Genoptix of the nature and scope of such request and Physician shall make
available, upon written request of Genoptix, all such books, documents or records. Physician shall indemnify and hold harmless Genoptix in the event that any amount of reimbursement is denied or
disallowed because of the failure of Physician or any subcontractor to comply with its obligations to maintain and make available books,
documents, or records pursuant to this subsection. Such indemnity shall include, but not be limited to the amount of reimbursement denied, plus any interest, penalties and legal costs. 

        This
section is intended to assure compliance with Section 1861 of the Social Security Act, as amended, and regulations directly pertinent to that Act. The obligations of
Physician under this section are strictly limited to compliance with those provisions, and shall be given effect only to the extent necessary to insure compliance with those provisions. In the event
that the requirements of those provisions are reduced or eliminated, the obligations of the parties under this section shall likewise be reduced or eliminated. 

        7.2    Covenant Not to Compete.    During the term of this Agreement, Physician shall not consult, manage or provide
any services similar to those required to be performed under this Agreement for any other clinical laboratory within Orange and San Diego Counties in California, without the prior written consent of
Genoptix, which consent may be withheld in Genoptix' sole discretion. Physician acknowledges that a breach of this Section 7.2 by Physician shall be deemed a material breach of this Agreement
and will result in irreparable injury to Genoptix, the precise amount of which is not readily ascertainable in monetary damages, and Genoptix, in addition to any other remedies, shall be entitled to
injunctive relief. 

        7.3    Nonsolicitation.    During the term of this Agreement and for a twelve- (12) month period commencing on
the date of the expiration or earlier termination of this Agreement, Physician shall not, without the prior written consent of Genoptix, employ or contract with, or solicit for employment or contract,
any employee or independent contractor of Genoptix to provide services similar to those provided in this Agreement. It is hereby agreed by both parties that in the event Physician employs or retains
any employee or independent contract of Genoptix, Physician shall pay to Genoptix as liquidated damages and not as a penalty a sum equal to one- (1) year's salary of the person so
employed or retained by Physician. This sum represents the reasonable endeavor by the parties hereto to estimate a fair compensation for the foreseeable and unforeseeable losses that might result from
any such violation of this Section 7.3 by Physician. 

        7.4    Confidential Information.    Physician recognizes and understands that, during the term of this Agreement,
Physician shall receive, have access to or otherwise become acquainted with various trade secrets, materials and other proprietary information related to Genoptix which is of a secret or 

4

 

confidential
nature ("Confidential Information"). During and after the term of this Agreement, Physician shall not use the Confidential Information for any purposes other than the performance of this
Agreement, and shall not disclose such Confidential Information for any purposes other than the performance of this Agreement, and shall not disclose such Confidential Information received by
Physician to any third party, without prior written consent of Genoptix. Upon the termination of this Agreement, Physician shall promptly deliver to Genoptix all documents and material of any kind
pertaining to Genoptix, and Physician will not take any documents, materials or copies thereof, whether on paper, magnetic or optical media or any other medium, containing any Confidential
Information. Physician acknowledges that a breach of this Section 7.4 by Physician will result in irreparable injury to Genoptix, the precise amount of which is not readily ascertainable in
monetary damages, and that Genoptix, in addition to any other remedies, shall be entitled to injunctive relief. 

        7.5    Authorization for Agreement.    The execution and performance of this Agreement by Physician and Genoptix have
been duly authorized by all necessary corporate action, and is not in violation of: (a) any law, rule or regulation of any governmental entity having jurisdiction over either Genoptix or
Physician, (b) the articles or bylaws of the parties hereto. This Agreement constitutes the valid obligation of Genoptix and Physician, enforceable in accordance with its terms. 

        7.6    Force Majeure.    Notwithstanding any provision contained herein to the contrary, Genoptix shall not be deemed
to be in default hereunder for failing to perform any of the obligations to be performed by Genoptix pursuant to this Agreement if such failure is the result of any labor dispute, act of God,
inability to obtain labor or materials, governmental restrictions or any other cause without fault beyond the reasonable control of Genoptix. In addition, under no circumstances shall Genoptix be
liable for consequential damages or otherwise, for any failure or interruption of any utility or building service at the Laboratory. Genoptix shall not be liable for injury to Physician's business or
medical practice or for any loss of income therefrom or for damage to the goods, wares or other property of Physician caused by any such failure or interruption. 

        7.7    No Third Party Beneficiary.    None of the provisions herein contained are intended by the parties, nor shall
they be deemed, to confer any benefit on any person not a party to this Agreement. 

        7.8    Governing Law.    This Agreement shall be construed and governed by and under the laws of the State of
California. 

        7.9    Entire Agreement; Amendments.    There are no other agreements or understandings, written or oral, between the
parties, regarding this Agreement other than as set forth herein. This Agreement shall not
be modified or amended except by a written document executed by both parties to this Agreement, and such written modification(s) shall be attached hereto. 

        7.10    Headings.    The headings set forth herein are for the purpose of convenient reference only, and shall have no
bearing whatsoever on the interpretation of this Agreement. 

        7.11    Notices.    All notices which either party is required or may desire to give to the other under or in
conjunction with this Agreement shall be in writing, and shall be deemed to have been duly given upon receipt if delivered in person or sent by facsimile to the party named below, or three
(3) business days after it is deposited in the United States mail, if by certified or registered mail, postage prepaid, 

5

 

return
receipt requested, or the next business day if it is transmitted by Federal Express or similar overnight delivery service, addressed as follows: 

	If to Genoptix:	 	Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121

Attn.: Chief Financial Officer
	

If to Physician:	
 	

Bashar Dabbas, M.D.

3398 Carmel Mountain Road

San Diego, CA 92121

or
to such other address(es) or person(s) as may be designated by Genoptix or Physician from time to time in accordance with the provisions of this Section 7.11. 

        7.12    Nonwaiver.    The waiver by either party of any breach of any term, covenant or condition contained herein
shall not be deemed to be a waiver of any subsequent breach of the same or any other term, covenant or condition contained herein. The subsequent acceptance of performance hereunder by a party shall
not be deemed to be a waiver of any preceding breach by the other party of any term, covenant or condition of this Agreement, other than the failure of such party to perform the particular duties so
accepted, regardless of such party's knowledge of such preceding breach at the time of acceptance of such performance. 

        7.13    Counterparts.    This Agreement may be executed in counterparts, each of which shall be deemed to be an
original, and all of such counterparts shall together constitute one and the same Agreement. 

        7.14    Severability.    If any provision of this Agreement shall be determined to be invalid, illegal, or
unenforceable in any jurisdiction, the validity, legality, and enforceability of the remaining provisions, and of such provision in other jurisdictions, shall not be affected or impaired thereby. 

        7.15    Additional Documents.    Each of the parties hereto agrees to execute any document or documents that may be
requested from time to time by the other party to implement or complete such party's obligations pursuant to this Agreement and to otherwise cooperate fully with such other party in connection with
the performance of such party's obligations under this Agreement. 

        7.16    Gender and Number.    All references to the neuter gender shall include the feminine or masculine gender and
vice versa, where applicable, and all references to the singular shall include the plural and vice versa, where applicable. 

        IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed on the day and year first written above. 

	GENOPTIX, INC.	 	PHYSICIAN
	

/s/  TINA S. NOVA      
 Signature

Tina S. Nova, Ph.D., President & CEO

Genoptix, Inc.	
 	

/s/  BASHAR DABBAS      
 Signature

Bashar Dabbas, M.D.

6

 
EXHIBIT A  

ADMINISTRATIVE SERVICES TO BE PROVIDED  

        Physician
shall: 

        (a)   Provide
general administration of the day-to-day operations of the Laboratory; 

        (b)   Implement
Genoptix policies and procedures regarding the Laboratory; 

        (c)   Ensure
the accuracy and timely delivery of clinical laboratory testing results; 

        (d)   Establish
criteria for routine and abnormal clinical laboratory test result transfer; 

        (e)   Assist
in the evaluation and coordination of developmental initiatives for Laboratory's clinical staff; 

        (f)    Perform
regular review of regional and national laboratories quality assurance data; 

        (g)   Assist
in the planning and arrangement of a cost effective annual budget for the Laboratory; 

        (h)   Provide
clinical diagnostic expertise for patients and physicians when full medical consultation is indicated; 

        (i)    Be
responsible for overall quality of the Laboratory; 

        (j)    Fulfill
all responsibilities required of laboratory directors supervising high complexity laboratories under the federal Clinical Laboratories Improvement Act; and 

        (k)   Provide
advice and assistance in connection with such other administrative duties as Genoptix may request from time to time. 

7

QuickLinks

Exhibit 10.16

RECITALS

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