Document:

Warrant issued by the Company to GE Capital Equity Investments Inc.

 Exhibit 10.5 
 WARRANT 
 NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUBJECT TO SECTION 6 BELOW, AND EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT, NO SALE OR DISPOSITION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED
THERETO OR AN OPINION OF COUNSEL FOR HOLDER, SATISFACTORY TO COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF A NO-ACTION LETTER TO THAT EFFECT FROM THE SECURITIES AND EXCHANGE COMMISSION. 

WARRANT TO PURCHASE 24,438 SHARES OF COMMON STOCK 
  

			
	No. CS-10FEB12-1	  	February 10, 2012

 THIS CERTIFIES THAT, for value received, GE Capital Equity Investments, Inc. (“Holder”)
is entitled to subscribe for and purchase up to such number of fully paid and nonassessable shares of Common Stock of BG MEDICINE, INC., a Delaware corporation (“Company”), as is equal to the Warrant Share Amount (as hereinafter defined)
at the Warrant Price (as hereinafter defined) per share, subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term “Common Stock” shall mean Company’s presently authorized common
stock, $0.001 par value per share, and any stock into which such common stock may hereafter be converted or exchanged and the term “Warrant Shares” shall mean the shares of Common Stock which Holder may acquire pursuant to this Warrant and
any other shares of stock into which such shares of Common Stock may hereafter be converted or exchanged. 
 1. Warrant Share Amount and
Warrant Price. The “Warrant Share Amount” means such whole number of shares of Common Stock as is equal to the quotient of (a) the product of (i) General Electric Capital Corporation’s Pro Rata Share of the Initial
Term Loan (as defined in the Loan and Security Agreement dated as of February 10, 2012, among General Electric Capital Corporation, as Agent, the Lenders (as defined therein), and Company, as Borrower, and the other entities or persons from
time to time party thereto as Guarantors, as amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”) made by Holder or its affiliates pursuant to the terms of the Loan Agreement, multiplied by
(ii) two and one-half percent (2.5%), divided by (b) the Warrant Price. The “Warrant Price” shall be $6.82 per share, subject to adjustment as provided in Section 7 below. 

2. Conditions to Exercise. The purchase right represented by this Warrant may be exercised at any time, or from time to time, in whole or in part
during the term commencing on the date hereof and ending at 5:00 P.M. Eastern Standard time on the tenth anniversary of the date of this Warrant (the “Expiration Date”). 
 3. Method of Exercise or Conversion; Payment; Issuance of Shares; Issuance of New Warrant. 
 (a) Cash Exercise. Subject to Section 2 hereof, the purchase right represented by this Warrant may be exercised by Holder hereof, in whole or in part, by the surrender of the original of this
Warrant (together with a duly executed Notice of Exercise in substantially the form attached hereto) at the principal office of Company (as set forth in Section 18 below) and by payment to Company, by certified or bank check, or wire transfer
of immediately available funds, of an amount equal to the then applicable Warrant Price per share multiplied by the number of Warrant Shares then being purchased. The date that the last of the original Warrant, Notice of Exercise and, if applicable,
payment is received by the Company shall be referred to as the “Exercise Date.” In the event of any exercise of the rights represented by this Warrant, 

 
certificates for the shares of stock so purchased shall be in the name of, and delivered to, Holder hereof, or to such other party as such Holder may direct (subject to the terms of transfer
contained herein and upon payment by such Holder hereof of any applicable transfer taxes). Such delivery shall be made within 30 days after the applicable Exercise Date and at Company’s expense and, unless this Warrant has been fully exercised
or expired, a new Warrant having terms and conditions substantially identical to this Warrant and representing the portion of the Warrant Shares, if any, with respect to which this Warrant shall not have been exercised, shall also be issued to
Holder hereof within 30 days after the applicable Exercise Date. 
 (b) Conversion. In lieu of exercising this Warrant as
specified in Section 3(a), Holder may from time to time convert this Warrant, in whole or in part, into Warrant Shares by surrender of the original of this Warrant (together with a duly executed Notice of Exercise in substantially the form
attached hereto) at the principal office of Company, in which event Company shall issue to Holder the number of Warrant Shares computed using the following formula: 

X = Y (A-B) 
  A 
 Where: 

X = the number of Warrant Shares to be issued to Holder. 

Y = the number of Warrant Shares requested to be purchased under this Warrant (at the date of such calculation).

 A = the Fair Market Value of one share of Common Stock (at the date of such calculation). 

B = Warrant Price (as adjusted to the date of such calculation). 

(c) Fair Market Value. For purposes of this Section 3, Fair Market Value of one share of Common Stock shall mean: 

(i) (x) the average of the last reported sale price quoted on the Nasdaq Stock Market, as reported by Bloomberg Financial Markets for the
five (5) trading days prior to the date of the Notice of Exercise, (y) if the Company’s Common Stock is not so traded, the average of the last reported sale price on any other exchange on which the Common Stock is listed, as reported
by Bloomberg Financial Markets for the five (5) trading days prior to the date of the Notice of Exercise, or (z) if the Company’s Common Stock is not so traded, the average for the five (5) trading days prior to the date of the
Notice of Exercise of the closing bid and asked prices of Common Stock quoted in the Over-The-Counter Market Summary, as reported by Bloomberg Financial Markets, or, if no last trade price is reported for such security by Bloomberg Financial
Markets, the average of the bid prices, or the ask prices, respectively, of any market makers for such security as reported in the “pink sheets” by Pink Sheets LLC; or 

(ii) In the event of an exercise in connection with a merger, acquisition or other consolidation in which Company is not the surviving
entity, the Fair Market Value of one share of Common Stock shall be the value to be received per share of Common Stock by the holders of the Common Stock in such transaction; or 

(iii) In any other instance, as determined in the reasonable good faith judgment of Company’s Board of Directors. 

  
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 In the event of Section 3(c)(ii) or 3(c)(iii) above, Company’s Chief Financial
Officer shall deliver a certificate, setting forth in reasonable detail the basis for and method of determination of the per share Fair Market Value of the Common Stock. Such certification must be made to Holder at least ten (10)
business days prior to the proposed effective date of the merger, consolidation, sale, or other triggering event as defined in Section 3(c)(ii) or 3(c)(iii). 
 (d) Automatic Exercise. Subject to Section 3(e)(ii), to the extent this Warrant is not previously exercised, it shall be deemed to have been automatically converted in accordance with
Sections 3(b), 3(c) and 3(e)(v) hereof (even if not surrendered) as of immediately before its expiration, involuntary termination or cancellation (including pursuant to Section 3(e)(ii)) (x) in the case of Sections 3(b) and 3(c), if
the then-Fair Market Value of a Warrant Share exceeds the then-Warrant Price, and (y) in the case of Section 3(e)(v), if the conditions set forth therein for the automatic exercise are satisfied, and unless in the case of any such Section
Holder notifies Company in writing to the contrary prior to such automatic exercise. 
 (e) Treatment of Warrant Upon
Acquisition of Company. 
 (i) Certain Definitions. For the purpose of this Warrant: “Acquisition”
means any sale, exclusive license, assignment, or other disposition of all or substantially all of the assets of Company, or any reorganization, consolidation, or merger of Company, or sale of outstanding Company securities by holders thereof, where
the holders of Company’s securities as of immediately before the transaction beneficially own less than a majority of the outstanding voting securities of the successor or surviving entity as of immediately after the transaction. For purposes
of this Section 3(e), “Affiliate” shall mean any person or entity that owns or controls directly or indirectly ten percent (10%) or more of the voting capital stock of Company, any person or entity that controls or is controlled
by or is under common control with such persons or entities, and each of such person’s or entity’s officers, directors, joint venturers or partners, as applicable. Company shall provide Holder with written notice of any proposed
Acquisition not later than ten (10) business days prior to the closing thereof setting forth the material terms and conditions thereof, and, together with such notice, shall provide Holder (a)(x) if Company is a publicly held company, with
copies of the transaction agreements for the proposed Acquisition that were filed with the Securities and Exchange Commission (the “SEC”) or (y) if Company is a private company and definitive transaction agreements for the proposed
Acquisition have been executed, with copies of such agreements, and (b)such other information regarding such proposed Acquisition as may reasonably be requested by Holder. 
 (ii) Acquisition for Cash. Holder agrees that, in the event of an Acquisition in which the sole consideration is cash, this Warrant shall be automatically exercised (or terminate) as provided in
Section 3(d) on and as of the closing of such Acquisition to the extent not previously exercised. 
 (iii) Asset
Sale. In the event of an Acquisition that is an arm’s length sale of all or substantially all of Company’s assets (and only its assets) to a third party that is not an Affiliate of Company (a “True Asset Sale”), Holder may
either (a) exercise its conversion or purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such Acquisition, or (b) permit the Warrant to continue until the Expiration Date
if Company continues as a going concern following the closing of any such True Asset Sale. 

  
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 (iv) Assumption of Warrant. Upon the closing of any Acquisition other than as
particularly described in Section 3(e)(ii) or 3(e)(iii) above, Company shall, unless Holder requests otherwise, cause the surviving or successor entity to assume this Warrant and the obligations of Company hereunder, and this Warrant shall,
from and after such closing, be exercisable for the same class, number and kind of securities, cash and other property as would have been paid for or in respect of the shares issuable (as of immediately prior to such closing) upon exercise in full
hereof as if such shares had been issued and outstanding on and as of such closing, at an aggregate Warrant Price equal to the aggregate Warrant Price in effect as of immediately prior to such closing (and subject to further adjustment thereafter
from time to time in accordance with the provisions of this Warrant). 
 (v) Early Termination of Warrant in Certain Other
Circumstances. Notwithstanding the foregoing provisions of Section 3(e)(iv), but subject to the terms of Section 3(d), in the event that the acquiror in an Acquisition does not agree to assume this Warrant at and as of the closing of
such Acquisition, this Warrant, to the extent not exercised or converted on or prior to such closing, shall be automatically exercised (or shall terminate) on and as of the closing of such Acquisition if all of the following conditions are met:
(A) the acquiror is subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended, (B) the class of stock or other security of the acquiror that would be received by
Holder in connection with such Acquisition were Holder to exercise or convert this Warrant on or prior to the closing thereof is listed for trading on a national securities exchange or approved for quotation on an automated inter-dealer quotation
system, and (C) the value (determined as of the closing of such Acquisition in accordance with the definitive agreements therefor) of the acquiror stock and/or other securities that would be received by Holder in respect of each Warrant Share
were Holder to exercise or convert this Warrant on or prior to the closing of such Acquisition is equal to or greater than three (3) times the then-effective Warrant Price. 
 4. Representations and Warranties of Holder and Company. 
 (a)
Representations and Warranties by Holder. Holder represents and warrants to Company with respect to this purchase as follows: 
 (i) Evaluation. Holder has substantial experience in evaluating and investing in private placement transactions of securities of companies similar to Company so that Holder is capable of evaluating
the merits and risks of its investment in Company and has the capacity to protect its interests. 
 (ii) Resale. Except
for transfers to an affiliate of Holder, Holder is acquiring this Warrant and the Warrant Shares issuable upon exercise of this Warrant (collectively the “Securities”) for investment for its own account and not with a view to, or for
resale in connection with, any distribution thereof. Holder understands that the Securities have not been registered under the Securities Act of 1933, as amended (the “Act”) by reason of a specific exemption from the registration
provisions of the Act which depends upon, among other things, the bona fide nature of the investment intent as expressed herein. 

(iii) Rule 144. Holder acknowledges that the Securities must be held indefinitely unless subsequently registered under the Act or
an exemption from such registration is available. Holder is aware of the provisions of Rule 144 promulgated under the Act. 

  
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 (iv) Accredited Investor. Holder is an “accredited investor” within the
meaning of Regulation D promulgated under the Act. 
 (v) Opportunity To Discuss. Holder has had an opportunity to discuss
Company’s business, management and financial affairs with its management and an opportunity to review Company’s facilities. Holder understands that such discussions, as well as the written information issued by Company, were intended to
describe the aspects of Company’s business and prospects which Company believes to be material but were not necessarily a thorough or exhaustive description. 
 (b)Representations and Warranties by Company. Company hereby represents and warrants to Holder that the statements in the following paragraphs of this Section 4(b) are true and correct as of
the date hereof: 
 (i)Corporate Organization and Authority. Company (a) is a corporation duly organized, validly
existing, and in good standing in its jurisdiction of incorporation, (b) has the corporate power and authority to own and operate its properties and to carry on its business as now conducted and as currently proposed to be conducted; and
(c) is qualified as a foreign corporation in all jurisdictions where such qualification is required, except, in the case of clause (c), where the failure to be so qualified would not, individually or in the aggregate, have a material adverse
effect. 
 (ii)Corporate Power . Company has all requisite legal and corporate power and authority to execute, issue and
deliver this Warrant, to issue the Warrant Shares issuable upon exercise or conversion of this Warrant, and to carry out and perform its obligations under this Warrant. 
 (iii)Authorization; Enforceability. All corporate action on the part of Company, its officers, directors and shareholders necessary for the authorization, execution, delivery and performance of its
obligations under this Warrant and for the authorization, issuance and delivery of this Warrant and the Warrant Shares issuable upon exercise of this Warrant has been taken and this Warrant constitutes the legally binding and valid obligation of
Company enforceable in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium, liquidation, conservatorship, receivership or similar laws relating to, or affecting
generally the enforcement of, creditor’s rights and remedies or by other equitable principles of general application (including any limitation of equitable remedies). 
 (iv)Valid Issuance of Warrant and Warrant Shares. This Warrant has been validly issued and is free of restrictions on transfer other than restrictions on transfer set forth herein and under
applicable state and federal securities laws. The Warrant Shares issuable upon exercise or conversion of this Warrant, when issued, sold and delivered in accordance with the terms of this Warrant for the consideration expressed herein, will be duly
and validly issued, fully paid and nonassessable, and will be free of restrictions on transfer other than restrictions on transfer under this Warrant and under applicable state and federal securities laws. Subject to applicable restrictions on
transfer, the issuance and delivery of this Warrant and the Warrant Shares issuable upon exercise or conversion of this Warrant are not subject to any preemptive or other similar rights or any liens or encumbrances except as specifically set forth
in Company’s Restated Certificate of Incorporation or this Warrant. Assuming the truth and accuracy of Holder’s 

  
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representations and warranties set forth in Section 4(a), the offer, sale and issuance of the Warrant Shares, as contemplated by this Warrant, are exempt from the prospectus and registration
requirements of applicable United States federal and state security laws, and neither Company nor any authorized agent acting on its behalf has or will take any action hereafter that would cause the loss of such exemption. 

(v) No Conflict. The execution, delivery, and performance of this Warrant will not result in (a) any violation of, be in
conflict with, or constitute a default under, with or without the passage of time or the giving of notice (1) any provision of Company’s Restated Certificate of Incorporation or by-laws; (2) any provision of any judgment, decree, or
order to which Company is a party, by which it is bound, or to which any of its material assets are subject; (3) except for results which would not adversely affect the rights of Holder under this Warrant, any contract, obligation, or
commitment to which Company is a party or by which it is bound; or (4) any statute, rule, or governmental regulation applicable to Company, or (b) the creation of any lien, charge or encumbrance upon any assets of Company. 

(vi) Reports. Company has previously furnished or made available to Holder via EDGAR at www.sec.gov complete and accurate
copies, as amended or supplemented, of its (a) Annual Report on Form 10-K for the fiscal year ended December 31, 2010, as filed with the SEC, and (b) all other reports filed by Company under Section 13 or subsections (a) or
(c) of Section 14 of the Securities Exchange Act of 1934 (as amended, the “Exchange Act”) with the SEC since December 31, 2011 (such reports are collectively referred to herein as the “Company Reports”). The
Company Reports constitute all of the documents required to be filed by Company under Section 13 or subsections (a) or (c) of Section 14 of the Exchange Act with the SEC from December 31, 2011 through the date of this
Warrant. The Company Reports complied in all material respects with the requirements of the Exchange Act and the rules and regulations thereunder when filed. As of their respective dates, the Company Reports did not contain any untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. 

5. Legends. 
 (a)
Legend. Each certificate representing the Warrant Shares shall be endorsed with substantially the following legend: 

THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”) AND MAY NOT BE SOLD,
TRANSFERRED (UNLESS SUCH TRANSFER IS TO AN AFFILIATE OF HOLDER) OR OTHERWISE DISPOSED OF, UNLESS COVERED BY AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT, A “NO ACTION” LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION WITH RESPECT
THERETO, SUCH TRANSACTION MEETS THE REQUIREMENTS OF RULE 144 OF THE ACT, OR AN OPINION OF COUNSEL SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY SUCH TRANSACTION IS EXEMPT FROM REGISTRATION. 

Company need not enter into its stock records a transfer of Warrant Shares unless the conditions specified in the foregoing legend are
satisfied. Company may also instruct its transfer agent not to allow the transfer of any of the Warrant Shares unless the conditions specified in the foregoing legend are satisfied. 

  
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 (b) Removal of Legend and Transfer Restrictions. The legend relating to the Act
endorsed on a certificate pursuant to paragraph 5(a) of this Warrant shall be removed and Company shall issue a certificate without such legend to Holder if (i) the Securities are registered under the Act and a prospectus meeting the
requirements of Section 10 of the Act is available in connection with the offer and sale thereof or (ii) Holder provides to Company an opinion of counsel for Holder reasonably satisfactory to Company, a noaction letter or interpretive
opinion of the staff of the SEC reasonably satisfactory to Company, or other evidence reasonably satisfactory to Company, to the effect that public sale, transfer or assignment of the Securities may be made without registration and without
compliance with any restriction such as Rule 144. 
 6. Transfers of Warrant. It shall be a condition to any transfer or exercise of this
Warrant that at the time of such transfer or exercise, Holder shall provide Company with a representation in writing that Holder or transferee is acquiring this Warrant and the shares of Common Stock to be issued upon exercise for investment
purposes only and not with a view to any sale or distribution, or will provide Company with a statement of pertinent facts covering any proposed distribution. As a further condition to any transfer of this Warrant or any or all of the shares of
Common Stock issuable upon exercise of this Warrant, other than a transfer registered under the Act, Company may request a legal opinion, in form and substance satisfactory to Company and its counsel, reciting the pertinent circumstances surrounding
the proposed transfer and stating that such transfer is exempt from the registration and prospectus delivery requirements of the Act. Company shall not require Holder to provide an opinion of counsel if the transfer is to an affiliate of Holder,
provided that any such transferee is an “accredited investor” within the meaning of Regulation D under the Act. As further condition to each transfer, at the request of Company, Holder shall surrender this Warrant to Company and the
transferee shall receive and accept a Warrant, of like tenor and date, executed by Company. Subject to the foregoing, this Warrant is transferable on the books of Company at its principal office by the registered Holder hereof upon surrender of this
Warrant properly endorsed. 
 7. Adjustment for Certain Events. The number and kind of securities purchasable upon the exercise of this
Warrant and the Warrant Price shall be subject to adjustment from time to time upon the occurrence of certain events, as follows: 
 (a) Reclassification or Merger. In case of (i) any reclassification or change of securities of the class issuable upon exercise of this Warrant (other than a change in par value, or from par
value to no par value, or from no par value to par value, or as a result of a subdivision or combination), (ii) any merger of Company with or into another corporation (other than a merger with another corporation in which Company is the
acquiring and the surviving corporation and which does not result in any reclassification or change of outstanding securities issuable upon exercise of this Warrant), or (iii) any sale of all or substantially all of the assets of Company,
Company, or such successor or purchasing corporation, as the case may be, shall duly execute and deliver to Holder a new Warrant (in form and substance substantially similar to this Warrant, as determined by Holder), or Company shall make
appropriate provision without the issuance of a new Warrant, so that Holder shall have the right to receive, at a total purchase price not to exceed that payable upon the exercise of the unexercised portion of this Warrant, and in lieu of the
Warrant Shares theretofore issuable upon exercise or conversion of this Warrant, the kind and amount of shares of stock, other securities, money and property receivable upon such reclassification, change, merger or sale by a holder of the number of
shares of Common Stock then purchasable under this Warrant, or in the case of such a merger or sale in which the consideration paid consists all or in part of assets other than securities of the successor or

  
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purchasing corporation, at the option of Holder, the securities of the successor or purchasing corporation having a value at the time of the transaction equivalent to the value of the Warrant
Shares purchasable upon exercise of this Warrant at the time of the transaction. Any new Warrant shall provide for adjustments that shall be as nearly equivalent as may be practicable to the adjustments provided for in this Section 7. The
provisions of this subparagraph (a) shall similarly apply to successive reclassifications, changes, mergers and transfers. 

(b) Subdivision or Combination of Shares. If Company at any time while this Warrant remains outstanding and unexpired shall
subdivide or combine its outstanding shares of Common Stock, the Warrant Price shall be proportionately decreased and the number of Warrant Shares issuable hereunder shall be proportionately increased in the case of a subdivision and the Warrant
Price shall be proportionately increased and the number of Warrant Shares issuable hereunder shall be proportionately decreased in the case of a combination. 
 (c) Stock Dividends and Other Distributions. If Company at any time while this Warrant is outstanding and unexpired shall (i) pay a dividend with respect to Common Stock payable in Common
Stock, then the Warrant Price shall be adjusted, from and after the date of determination of shareholders entitled to receive such dividend or distribution, to that price determined by multiplying the Warrant Price in effect immediately prior to
such date of determination by a fraction (A) the numerator of which shall be the total number of shares of Common Stock outstanding immediately prior to such dividend or distribution, and (B) the denominator of which shall be the total
number of shares of Common Stock outstanding immediately after such dividend or distribution; or (ii) make any other distribution with respect to Common Stock (except any distribution specifically provided for in Sections 7(a) and 7(b)),
then, in each such case, provision shall be made by Company such that Holder shall receive upon exercise of this Warrant a proportionate share of any such dividend or distribution as though it were Holder of the Warrant Shares as of the record date
fixed for the determination of the shareholders of Company entitled to receive such dividend or distribution. 
 (d)
Adjustment of Number of Shares. Upon each adjustment in the Warrant Price, the number of Warrant Shares purchasable hereunder shall be adjusted, to the nearest whole share, to the product obtained by multiplying the number of Warrant Shares
purchasable immediately prior to such adjustment in the Warrant Price by a fraction, the numerator of which shall be the Warrant Price immediately prior to such adjustment and the denominator of which shall be the Warrant Price immediately
thereafter. 
 8. Notice of Adjustments; Redemption. Whenever any Warrant Price or the kind or number of securities issuable under this
Warrant shall be adjusted pursuant to Section 7 hereof, Company shall prepare a certificate signed by an officer of Company setting forth, in reasonable detail, the event requiring the adjustment, the amount of the adjustment, the method by
which such adjustment was calculated, and the Warrant Price and number or kind of shares issuable upon exercise of this Warrant after giving effect to such adjustment, and shall cause copies of such certificate to be mailed (by certified or
registered mail, return receipt required, postage prepaid) within thirty (30) days of such adjustment to Holder as set forth in Section 18 hereof. 
 9. Financial and Other Reports. If at any time up to the earlier of the Expiration Date and the complete exercise of this Warrant, Company is no longer subject to the reporting requirements of
Section 13 or Section 15(d) of the Exchange Act, Company shall furnish to Holder (a) quarterly unaudited consolidated and, if available, consolidating balance sheets, statements of operations and cash flow statements within 45 days of
each fiscal quarter, certified by Company’s president or chief financial officer, and (b) Company’s complete annual audited consolidated and, if available, consolidating balance

  
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sheets, statements of operations and cash flow statements certified by an independent certified public accountant selected by Company within 120 days of the fiscal year end. Within 30 days of the
end of each calendar quarter, if the Company is a private company, Company shall also deliver to Holder an updated capitalization table of Company in the form attached hereto as Annex A. All financial statements delivered to Holder pursuant to this
Section 9 are to be prepared using GAAP (subject, in the case of unaudited financial statements, to the absence of footnotes and normal year-end audit adjustments) and, if Company is a publicly held company, are to be in compliance with
applicable SEC requirements. 
 10. Reserved. 
 11. No Fractional Shares. No fractional share of Common Stock will be issued in connection with any exercise or conversion hereunder, but in lieu of such fractional share Company shall make a cash
payment therefor upon the basis of the Warrant Price then in effect. 
 12. Charges, Taxes and Expenses. Subject to the provisions of
Section 3(a) related to the payment of transfer taxes, issuance of certificates for shares of Common Stock upon the exercise or conversion of this Warrant shall be made without charge to Holder for any United States or state of the United
States documentary stamp tax or other incidental expense with respect to the issuance of such certificate, all of which taxes and expenses shall be paid by Company, and such certificates shall be issued in the name of Holder. 

13. No Shareholder Rights Until Exercise. Except as expressly provided herein, this Warrant does not entitle Holder to any voting rights or other
rights as a shareholder of Company prior to the exercise hereof. 
 14. Registry of Warrant. Company shall maintain a registry showing
the name and address of the registered Holder of this Warrant. This Warrant may be surrendered for exchange or exercise, in accordance with its terms, at such office or agency of Company, and Company and Holder shall be entitled to rely in all
respects, prior to written notice to the contrary, upon such registry. 
 15. Loss, Theft, Destruction or Mutilation of Warrant. Upon
receipt by Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant, and, in the case of loss, theft, or destruction, upon delivery of an indemnity reasonably satisfactory to Company in form and
amount, and, if mutilated, upon surrender and cancellation of this Warrant, Company will execute and deliver a new Warrant, having terms and conditions substantially identical to this Warrant, in lieu hereof. 

16. Miscellaneous. 
 (a)
Issue Date. The provisions of this Warrant shall be construed and shall be given effect in all respect as if it had been issued and delivered by Company on the date hereof. 

(b) Successors. This Warrant shall be binding upon any successors or assigns of Company. 

(c) Headings. The headings used in this Warrant are used for convenience only and are not to be considered in construing or
interpreting this Warrant. 
 (d) Saturdays, Sundays, Holidays. If the last or appointed day for the taking of any action
or the expiration of any right required or granted herein shall be a Saturday or a Sunday or shall be a legal holiday in the State of New York, then such action may be taken or such right may be exercised on the next succeeding day that is not a
legal holiday. 

  
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 (e) Attorney’s Fees. In the event of any dispute between the parties concerning
the terms and provisions of this Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorney’s fees. 

(f) Amendment and Waiver. Any term or provision of this Warrant may be amended or modified, and any term or provision hereof may be
waived (either generally or in a particular instance and either retroactively or prospectively) upon the written consent of Company and Holder. No waivers of any term, condition or provision of this Warrant, in any one or more instances, shall be
deemed to be, or construed as, a further or continuing waiver of any such term, condition or provision. 
 17. No Impairment. Company
will not, by amendment of its Restated Certificate of Incorporation or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying
out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of Holder hereof against impairment. 
 18. Addresses. Any notice required or permitted hereunder shall be in writing and shall be mailed by overnight courier, registered or certified mail, return receipt requested, and postage prepaid,
or otherwise delivered by hand or by messenger, addressed as set forth below, or at such other address as Company or Holder hereof shall have furnished to the other party in accordance with the delivery instructions set forth in this
Section 18. 
  

			
	If to Company:	  	BG Medicine, Inc.
		  	610 Lincoln Street North
		  	Waltham, Massachusetts 02451
		  	Attn: Chief Financial Officer
		
	If to Holder:	  	GE Capital Equity Investments, Inc.
		  	c/o GE Healthcare Financial Services, Inc.
		  	Bethesda, Maryland 20814
		  	Attn: Senior Vice President of Risk – Life Science
		  	Finance
		
	With copies to:	  	GE Healthcare Financial Services, Inc.
		  	Two Bethesda Metro Center, Suite 600
		  	Bethesda, Maryland 20814
		  	Attn: General Counsel
		
	and	  	GE Equity
		  	201 Merritt 7
		  	Norwalk, Connecticut 06851
		  	Attn: Team Leader –HFS/BG Medicine

 If mailed by registered or certified mail, return receipt requested, and postage prepaid, notice shall be
deemed to be given five (5) days after being sent, and if sent by overnight courier, by hand or by messenger, notice shall be deemed to be given when delivered (if on a business day, and if not, on the next business day). 

  
 10 

 19. WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO HEREBY WAIVES TO THE FULLEST EXTENT PERMITTED BY
APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS WARRANT OR THE WARRANT SHARES. 
 20. GOVERNING LAW. THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 [Remainder of page intentionally left blank] 

  
 11 

 IN WITNESS WHEREOF, Company has caused this Warrant to be executed by its officer thereunto
duly authorized. 
  

			
	BG MEDICINE, INC.
		
	By:	 	/s/ Michael W. Rogers
		 	Name: Michael W. Rogers
		 	Title: CFO & EVP

 Dated as of: February 10, 2012 

 NOTICE OF EXERCISE 
 To: 
 BG Medicine, Inc. 
 610 Lincoln Street North 
 Waltham, Massachusetts 02451 

Attn: Chief Financial Officer 
  

	1.	The undersigned Warrantholder (“Holder”) elects to acquire shares of the Common Stock (the “Common Stock”) of BG MEDICINE, INC. (the
“Company”), pursuant to the terms of the Stock Purchase Warrant No. CS-10FEB12-1 dated February 10, 2012 (the “Warrant”). 

  

	2.	Holder exercises its rights under the Warrant as set forth below: 

  

			
	(            )	  	Holder elects to purchase             shares of Common Stock as provided in Section 3(a) and tenders herewith a
check in the amount of $            as payment of the purchase price.
		
	(            )	  	Holder elects to convert the purchase rights into shares of Common Stock as provided in Section 3(b) of the Warrant.

  

	3.	Holder surrenders the Warrant with this Notice of Exercise. 

 Holder represents that (i) it is acquiring the aforesaid shares of Common Stock for investment and not with a view to or for resale in connection with distribution, (ii) it has no present
intention of distributing or reselling the shares and (iii) it has not engaged in any short sales of Common Stock during the 12 month period preceding the date of this Notice of Exercise. 

.Please issue a certificate representing the shares of the Common Stock in the name of Holder or in such other name as is specified below: 

 

					
			
	 Name:
	 	 	 	
			
	 Address:
	 	 	 	
			
	 Taxpayer I.D.:
	 	 	 	

  

			
	GE CAPITAL EQUITY INVESTMENTS, INC.
		
	By:	 	 
		 	Name
		 	Title:
	
	Date:             ,
20            

 ANNEX A 
 FORM OF CAPITALIZATION TABLEWarrant issued by the Company to Comerica Bank

 Exhibit 10.6 
 WARRANT 
 NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. SUBJECT TO SECTION 6 BELOW, AND EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT, NO SALE OR DISPOSITION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED
THERETO OR AN OPINION OF COUNSEL FOR HOLDER, SATISFACTORY TO COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF A NO-ACTION LETTER TO THAT EFFECT FROM THE SECURITIES AND EXCHANGE COMMISSION. 

WARRANT TO PURCHASE 12,219 SHARES OF COMMON STOCK 
  

			
	No. CS-10FEB12-2	 	February 10, 2012            

 THIS CERTIFIES THAT, for value received, COMERICA BANK, a Texas banking association, or its
assignees (“Holder”) is entitled to subscribe for and purchase up to such number of fully paid and nonassessable shares of Common Stock of BG MEDICINE, INC., a Delaware corporation (“Company”), as is equal to the Warrant Share
Amount (as hereinafter defined) at the Warrant Price (as hereinafter defined) per share, subject to the provisions and upon the terms and conditions hereinafter set forth. As used herein, the term “Common Stock” shall mean Company’s
presently authorized common stock, $0.001 par value per share, and any stock into which such common stock may hereafter be converted or exchanged and the term “Warrant Shares” shall mean the shares of Common Stock which Holder may acquire
pursuant to this Warrant and any other shares of stock into which such shares of Common Stock may hereafter be converted or exchanged. 
 1.
Warrant Share Amount and Warrant Price. The “Warrant Share Amount” means such whole number of shares of Common Stock as is equal to the quotient of (a) the product of (i) Holder’s Pro Rata Share of the Initial
Term Loan (as defined in the Loan and Security Agreement dated as of February 10, 2012, among General Electric Capital Corporation, as Agent, the Lenders (as defined therein), and Company, as Borrower, and the other entities or persons from
time to time party thereto as Guarantors, as amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”) made by Holder or its affiliates pursuant to the terms of the Loan Agreement, multiplied by
(ii) two and one-half percent (2.5%), divided by (b) the Warrant Price. The “Warrant Price” shall be $6.82 per share, subject to adjustment as provided in Section 7 below. 

2. Conditions to Exercise. The purchase right represented by this Warrant may be exercised at any time, or from time to time, in whole or in part
during the term commencing on the date hereof and ending at 5:00 P.M. Eastern Standard time on the tenth anniversary of the date of this Warrant (the “Expiration Date”). 
 3. Method of Exercise; Payment; Issuance of Shares; Issuance of New Warrant. 

(a) Cash Exercise. Subject to Section 2 hereof, the purchase right represented by this Warrant may be exercised by Holder
hereof, in whole or in part, by the surrender of the original of this Warrant (together with a duly executed Notice of Exercise in substantially the form attached hereto) at the principal office of Company (as set forth in Section 18 below) and
by payment to Company, by certified or bank check, or wire transfer of immediately available funds, of an amount equal to the then applicable Warrant Price per share multiplied by the number of Warrant Shares then being purchased. The date that the
last of the original Warrant, Notice of Exercise and, if applicable, payment is received by the Company shall be referred to as the 

 
“Exercise Date.” In the event of any exercise of the rights represented by this Warrant, certificates for the shares of stock so purchased shall be in the name of, and delivered to,
Holder hereof, or to such other party as such Holder may direct (subject to the terms of transfer contained herein and upon payment by such Holder hereof of any applicable transfer taxes). Such delivery shall be made within 30 days after the
applicable Exercise Date and at Company’s expense and, unless this Warrant has been fully exercised or expired, a new Warrant having terms and conditions substantially identical to this Warrant and representing the portion of the Warrant
Shares, if any, with respect to which this Warrant shall not have been exercised, shall also be issued to Holder hereof within 30 days after the applicable Exercise Date. 
 (b) Reserved. 
 (c) Fair Market Value. For purposes of this
Section 3, Fair Market Value of one share of Common Stock shall mean: 
 (i) (x) the average of the last reported sale price
quoted on the Nasdaq Stock Market, as reported by Bloomberg Financial Markets for the five (5) trading days prior to the date of the Notice of Exercise, (y) if the Company’s Common Stock is not so traded, the average of the last
reported sale price on any other exchange on which the Common Stock is listed, as reported by Bloomberg Financial Markets for the five (5) trading days prior to the date of the Notice of Exercise, or (z) if the Company’s Common Stock
is not so traded, the average for the five (5) trading days prior to the date of the Notice of Exercise of the closing bid and asked prices of Common Stock quoted in the Over-The-Counter Market Summary, as reported by Bloomberg Financial
Markets, or, if no last trade price is reported for such security by Bloomberg Financial Markets, the average of the bid prices, or the ask prices, respectively, of any market makers for such security as reported in the “pink sheets” by
Pink Sheets LLC; or 
 (ii) In the event of an exercise in connection with a merger, acquisition or other consolidation in which
Company is not the surviving entity, the Fair Market Value of one share of Common Stock shall be the value to be received per share of Common Stock by the holders of the Common Stock in such transaction; or 

(iii) In any other instance, as determined in the reasonable good faith judgment of Company’s Board of Directors. 

In the event of Section 3(c)(ii) or 3(c)(iii) above, Company’s Chief Financial Officer shall deliver a certificate, setting
forth in reasonable detail the basis for and method of determination of the per share Fair Market Value of the Common Stock. Such certification must be made to Holder at least ten (10) business days prior to the proposed effective date of
the merger, consolidation, sale, or other triggering event as defined in Section 3(c)(ii) or 3(c)(iii). 
 (d)
Reserved. 
 (e) Treatment of Warrant Upon Acquisition of Company. 

(i) Certain Definitions. For the purpose of this Warrant: “Acquisition” means any sale, exclusive license, assignment, or
other disposition of all or substantially all of the assets of Company, or any reorganization, consolidation, or merger of Company, or sale of outstanding Company securities by holders thereof, where the holders of Company’s securities as of
immediately before the transaction beneficially own less than a majority 

  
 2 

 
of the outstanding voting securities of the successor or surviving entity as of immediately after the transaction. For purposes of this Section 3(e), “Affiliate” shall mean any
person or entity that owns or controls directly or indirectly ten percent (10%) or more of the voting capital stock of Company, any person or entity that controls or is controlled by or is under common control with such persons or entities, and
each of such person’s or entity’s officers, directors, joint venturers or partners, as applicable. Company shall provide Holder with written notice of any proposed Acquisition not later than ten (10) business days prior to the closing
thereof setting forth the material terms and conditions thereof, and, together with such notice, shall provide Holder (a)(x) if Company is a publicly held company, with copies of the transaction agreements for the proposed Acquisition that were
filed with the Securities and Exchange Commission (the “SEC”) or (y) if Company is a private company and definitive transaction agreements for the proposed Acquisition have been executed, with copies of such agreements, and (b)such
other information regarding such proposed Acquisition as may reasonably be requested by Holder. 
 (ii) Acquisition for
Cash. Holder agrees that, in the event of an Acquisition in which the sole consideration is cash, Holder may either (a) exercise its purchase right under this Warrant and such exercise will be deemed effective immediately prior to the
consummation of such Acquisition or (b) this Warrant shall be automatically terminated on and as of the closing of such Acquisition to the extent not previously exercised. 
 (iii) Asset Sale. In the event of an Acquisition that is an arm’s length sale of all or substantially all of Company’s assets (and only its assets) to a third party that is not an
Affiliate of Company (a “True Asset Sale”), Holder may either (a) exercise its purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such Acquisition, or (b) permit
the Warrant to continue until the Expiration Date if Company continues as a going concern following the closing of any such True Asset Sale. 
 (iv) Assumption of Warrant. Upon the closing of any Acquisition other than as particularly described in Section 3(e)(ii) or 3(e)(iii) above, Company shall, unless Holder requests otherwise,
cause the surviving or successor entity to assume this Warrant and the obligations of Company hereunder, and this Warrant shall, from and after such closing, be exercisable for the same class, number and kind of securities, cash and other property
as would have been paid for or in respect of the shares issuable (as of immediately prior to such closing) upon exercise in full hereof as if such shares had been issued and outstanding on and as of such closing, at an aggregate Warrant Price equal
to the aggregate Warrant Price in effect as of immediately prior to such closing (and subject to further adjustment thereafter from time to time in accordance with the provisions of this Warrant). 

(v) Early Termination of Warrant in Certain Other Circumstances. Notwithstanding the foregoing provisions of Section 3(e)(iv),
in the event that the acquiror in an Acquisition does not agree to assume this Warrant at and as of the closing of such Acquisition, this Warrant, to the extent not exercised or converted on or prior to such closing, shall be automatically exercised
(or shall terminate) on and as of the closing of such Acquisition if all of the following conditions are met: (A) the acquiror is subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of
1934, as amended, (B) the class of stock or other security of the acquiror that would be received by Holder in connection with such Acquisition were Holder to exercise or 

  
 3 

 
convert this Warrant on or prior to the closing thereof is listed for trading on a national securities exchange or approved for quotation on an automated inter-dealer quotation system, and
(C) the value (determined as of the closing of such Acquisition in accordance with the definitive agreements therefor) of the acquiror stock and/or other securities that would be received by Holder in respect of each Warrant Share were Holder
to exercise or convert this Warrant on or prior to the closing of such Acquisition is equal to or greater than three (3) times the then-effective Warrant Price. 
 4. Representations and Warranties of Holder and Company. 
 (a)
Representations and Warranties by Holder. Holder represents and warrants to Company with respect to this purchase as follows: 
 (i) Evaluation. Holder has substantial experience in evaluating and investing in private placement transactions of securities of companies similar to Company so that Holder is capable of evaluating
the merits and risks of its investment in Company and has the capacity to protect its interests. 
 (ii) Resale. Except
for transfers to an affiliate of Holder, Holder is acquiring this Warrant and the Warrant Shares issuable upon exercise of this Warrant (collectively the “Securities”) for investment for its own account and not with a view to, or for
resale in connection with, any distribution thereof. Holder understands that the Securities have not been registered under the Securities Act of 1933, as amended (the “Act”) by reason of a specific exemption from the registration
provisions of the Act which depends upon, among other things, the bona fide nature of the investment intent as expressed herein. 

(iii) Rule 144. Holder acknowledges that the Securities must be held indefinitely unless subsequently registered under the Act or
an exemption from such registration is available. Holder is aware of the provisions of Rule 144 promulgated under the Act. 

(iv) Accredited Investor. Holder is an “accredited investor” within the meaning of Regulation D promulgated under the
Act. 
 (v) Opportunity To Discuss. Holder has had an opportunity to discuss Company’s business, management and
financial affairs with its management and an opportunity to review Company’s facilities. Holder understands that such discussions, as well as the written information issued by Company, were intended to describe the aspects of Company’s
business and prospects which Company believes to be material but were not necessarily a thorough or exhaustive description. 

(b) Representations and Warranties by Company. Company hereby represents and warrants to Holder that the statements in the
following paragraphs of this Section 4(b) are true and correct as of the date hereof: 
 (i) Corporate Organization and
Authority. Company (a) is a corporation duly organized, validly existing, and in good standing in its jurisdiction of incorporation, (b) has the corporate power and authority to own and operate its properties and to carry on its
business as now conducted and as currently proposed to be conducted; and (c) is qualified as a foreign corporation in all jurisdictions where such qualification is required, except, in the case of clause (c), where the failure to be so
qualified would not, individually or in the aggregate, have a material adverse effect. 

  
 4 

 (ii) Corporate Power . Company has all requisite legal and corporate power and
authority to execute, issue and deliver this Warrant, to issue the Warrant Shares issuable upon exercise of this Warrant, and to carry out and perform its obligations under this Warrant. 

(iii) Authorization; Enforceability. All corporate action on the part of Company, its officers, directors and shareholders
necessary for the authorization, execution, delivery and performance of its obligations under this Warrant and for the authorization, issuance and delivery of this Warrant and the Warrant Shares issuable upon exercise of this Warrant has been taken
and this Warrant constitutes the legally binding and valid obligation of Company enforceable in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium, liquidation,
conservatorship, receivership or similar laws relating to, or affecting generally the enforcement of, creditor’s rights and remedies or by other equitable principles of general application (including any limitation of equitable remedies).

 (iv) Valid Issuance of Warrant and Warrant Shares. This Warrant has been validly issued and is free of restrictions on
transfer other than restrictions on transfer set forth herein and under applicable state and federal securities laws. The Warrant Shares issuable upon exercise of this Warrant, when issued, sold and delivered in accordance with the terms of this
Warrant for the consideration expressed herein, will be duly and validly issued, fully paid and nonassessable, and will be free of restrictions on transfer other than restrictions on transfer under this Warrant and under applicable state and federal
securities laws. Subject to applicable restrictions on transfer, the issuance and delivery of this Warrant and the Warrant Shares issuable upon exercise of this Warrant are not subject to any preemptive or other similar rights or any liens or
encumbrances except as specifically set forth in Company’s Restated Certificate of Incorporation or this Warrant. Assuming the truth and accuracy of Holder’s representations and warranties set forth in Section 4(a), the offer, sale
and issuance of the Warrant Shares, as contemplated by this Warrant, are exempt from the prospectus and registration requirements of applicable United States federal and state security laws, and neither Company nor any authorized agent acting on its
behalf has or will take any action hereafter that would cause the loss of such exemption. 
 (v) No Conflict. The
execution, delivery, and performance of this Warrant will not result in (a) any violation of, be in conflict with, or constitute a default under, with or without the passage of time or the giving of notice (1) any provision of
Company’s Restated Certificate of Incorporation or by-laws; (2) any provision of any judgment, decree, or order to which Company is a party, by which it is bound, or to which any of its material assets are subject; (3) except for
results which would not adversely affect the rights of Holder under this Warrant, any contract, obligation, or commitment to which Company is a party or by which it is bound; or (4) any statute, rule, or governmental regulation applicable to
Company, or (b) the creation of any lien, charge or encumbrance upon any assets of Company. 
 (vi) Reports. Company
has previously furnished or made available to Holder via EDGAR at www.sec.gov complete and accurate copies, as amended or supplemented, of its (a) Annual Report on Form 10-K for the fiscal year ended December 31, 2010, as filed with
the SEC, and (b) all other reports filed by Company under Section 13 or subsections (a) or (c) of Section 14 of the Securities Exchange Act of 1934 (as amended, the 

  
 5 

 
“Exchange Act”) with the SEC since December 31, 2011 (such reports are collectively referred to herein as the “Company Reports”). The Company Reports constitute all of
the documents required to be filed by Company under Section 13 or subsections (a) or (c) of Section 14 of the Exchange Act with the SEC from December 31, 2011 through the date of this Warrant. The Company Reports complied in
all material respects with the requirements of the Exchange Act and the rules and regulations thereunder when filed. As of their respective dates, the Company Reports did not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. 
 5. Legends. 
 (a) Legend. Each certificate representing the Warrant
Shares shall be endorsed with substantially the following legend: 
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”) AND MAY NOT BE SOLD, TRANSFERRED (UNLESS SUCH TRANSFER IS TO AN AFFILIATE OF HOLDER) OR OTHERWISE DISPOSED OF, UNLESS COVERED BY AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT, A “NO
ACTION” LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION WITH RESPECT THERETO, SUCH TRANSACTION MEETS THE REQUIREMENTS OF RULE 144 OF THE ACT, OR AN OPINION OF COUNSEL SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY SUCH TRANSACTION IS
EXEMPT FROM REGISTRATION. 
 Company need not enter into its stock records a transfer of Warrant Shares unless the conditions
specified in the foregoing legend are satisfied. Company may also instruct its transfer agent not to allow the transfer of any of the Warrant Shares unless the conditions specified in the foregoing legend are satisfied. 

(b) Removal of Legend and Transfer Restrictions. The legend relating to the Act endorsed on a certificate pursuant to paragraph
5(a) of this Warrant shall be removed and Company shall issue a certificate without such legend to Holder if (i) the Securities are registered under the Act and a prospectus meeting the requirements of Section 10 of the Act is available in
connection with the offer and sale thereof or (ii) Holder provides to Company an opinion of counsel for Holder reasonably satisfactory to Company, a noaction letter or interpretive opinion of the staff of the SEC reasonably satisfactory to
Company, or other evidence reasonably satisfactory to Company, to the effect that public sale, transfer or assignment of the Securities may be made without registration and without compliance with any restriction such as Rule 144. 

6. Transfers of Warrant. It shall be a condition to any transfer or exercise of this Warrant that at the time of such transfer or exercise, Holder
shall provide Company with a representation in writing that Holder or transferee is acquiring this Warrant and the shares of Common Stock to be issued upon exercise for investment purposes only and not with a view to any sale or distribution, or
will provide Company with a statement of pertinent facts covering any proposed distribution. As a further condition to any transfer of this Warrant or any or all of the shares of Common Stock issuable upon exercise of this Warrant, other than a
transfer registered under the Act, Company may request a legal opinion, in form and substance satisfactory to Company and its counsel, reciting the pertinent circumstances surrounding the proposed transfer and stating that such transfer is exempt
from the registration and prospectus delivery 

  
 6 

 
requirements of the Act. Company shall not require Holder to provide an opinion of counsel if the transfer is to an affiliate of Holder, provided that any such transferee is an “accredited
investor” within the meaning of Regulation D under the Act. As further condition to each transfer, at the request of Company, Holder shall surrender this Warrant to Company and the transferee shall receive and accept a Warrant, of like tenor
and date, executed by Company. Subject to the foregoing, this Warrant is transferable on the books of Company at its principal office by the registered Holder hereof upon surrender of this Warrant properly endorsed. After receipt of the executed
Warrant, Holder will transfer all of this Warrant to Comerica Ventures Incorporated, a non-banking subsidiary of Comerica Bank (“Ventures”), and may do so without further notice to Company. 

7. Adjustment for Certain Events. The number and kind of securities purchasable upon the exercise of this Warrant and the Warrant Price shall be
subject to adjustment from time to time upon the occurrence of certain events, as follows: 
 (a) Reclassification or
Merger. In case of (i) any reclassification or change of securities of the class issuable upon exercise of this Warrant (other than a change in par value, or from par value to no par value, or from no par value to par value, or as a result
of a subdivision or combination), (ii) any merger of Company with or into another corporation (other than a merger with another corporation in which Company is the acquiring and the surviving corporation and which does not result in any
reclassification or change of outstanding securities issuable upon exercise of this Warrant), or (iii) any sale of all or substantially all of the assets of Company, Company, or such successor or purchasing corporation, as the case may be,
shall duly execute and deliver to Holder a new Warrant (in form and substance substantially similar to this Warrant, as determined by Holder), or Company shall make appropriate provision without the issuance of a new Warrant, so that Holder shall
have the right to receive, at a total purchase price not to exceed that payable upon the exercise of the unexercised portion of this Warrant, and in lieu of the Warrant Shares theretofore issuable upon exercise of this Warrant, the kind and amount
of shares of stock, other securities, money and property receivable upon such reclassification, change, merger or sale by a holder of the number of shares of Common Stock then purchasable under this Warrant, or in the case of such a merger or sale
in which the consideration paid consists all or in part of assets other than securities of the successor or purchasing corporation, at the option of Holder, the securities of the successor or purchasing corporation having a value at the time of the
transaction equivalent to the value of the Warrant Shares purchasable upon exercise of this Warrant at the time of the transaction. Any new Warrant shall provide for adjustments that shall be as nearly equivalent as may be practicable to the
adjustments provided for in this Section 7. The provisions of this subparagraph (a) shall similarly apply to successive reclassifications, changes, mergers and transfers. 

(b) Subdivision or Combination of Shares. If Company at any time while this Warrant remains outstanding and unexpired shall
subdivide or combine its outstanding shares of Common Stock, the Warrant Price shall be proportionately decreased and the number of Warrant Shares issuable hereunder shall be proportionately increased in the case of a subdivision and the Warrant
Price shall be proportionately increased and the number of Warrant Shares issuable hereunder shall be proportionately decreased in the case of a combination. 
 (c) Stock Dividends and Other Distributions. If Company at any time while this Warrant is outstanding and unexpired shall (i) pay a dividend with respect to Common Stock payable in Common
Stock, then the Warrant Price shall be adjusted, from and after the date of determination of shareholders entitled to receive such dividend or distribution, to that price determined by multiplying the Warrant Price in effect immediately prior to
such date of determination by a fraction (A) the numerator of which shall be the total number of shares of Common Stock 

  
 7 

 
outstanding immediately prior to such dividend or distribution, and (B) the denominator of which shall be the total number of shares of Common Stock outstanding immediately after such
dividend or distribution; or (ii) make any other distribution with respect to Common Stock (except any distribution specifically provided for in Sections 7(a) and 7(b)), then, in each such case, provision shall be made by Company such that
Holder shall receive upon exercise of this Warrant a proportionate share of any such dividend or distribution as though it were Holder of the Warrant Shares as of the record date fixed for the determination of the shareholders of Company entitled to
receive such dividend or distribution. 
 (d) Adjustment of Number of Shares. Upon each adjustment in the Warrant Price,
the number of Warrant Shares purchasable hereunder shall be adjusted, to the nearest whole share, to the product obtained by multiplying the number of Warrant Shares purchasable immediately prior to such adjustment in the Warrant Price by a
fraction, the numerator of which shall be the Warrant Price immediately prior to such adjustment and the denominator of which shall be the Warrant Price immediately thereafter. 
 8. Notice of Adjustments; Redemption. Whenever any Warrant Price or the kind or number of securities issuable under this Warrant shall be adjusted pursuant to Section 7 hereof, Company shall
prepare a certificate signed by an officer of Company setting forth, in reasonable detail, the event requiring the adjustment, the amount of the adjustment, the method by which such adjustment was calculated, and the Warrant Price and number or kind
of shares issuable upon exercise of this Warrant after giving effect to such adjustment, and shall cause copies of such certificate to be mailed (by certified or registered mail, return receipt required, postage prepaid) within
thirty (30) days of such adjustment to Holder as set forth in Section 18 hereof. 
 9. Financial and Other Reports. If at
any time up to the earlier of the Expiration Date and the complete exercise of this Warrant, Company is no longer subject to the reporting requirements of Section 13 or Section 15(d) of the Exchange Act, Company shall furnish to Holder
(a) quarterly unaudited consolidated and, if available, consolidating balance sheets, statements of operations and cash flow statements within 45 days of each fiscal quarter, certified by Company’s president or chief financial officer, and
(b) Company’s complete annual audited consolidated and, if available, consolidating balance sheets, statements of operations and cash flow statements certified by an independent certified public accountant selected by Company within 120
days of the fiscal year end. Within 30 days of the end of each calendar quarter, if the Company is a private company, Company shall also deliver to Holder an updated capitalization table of Company in the form attached hereto as Annex A. All
financial statements delivered to Holder pursuant to this Section 9 are to be prepared using GAAP (subject, in the case of unaudited financial statements, to the absence of footnotes and normal year-end audit adjustments) and, if Company is a
publicly held company, are to be in compliance with applicable SEC requirements. 
 10. Reserved. 

11. No Fractional Shares. No fractional share of Common Stock will be issued in connection with any exercise hereunder, but in lieu of such
fractional share Company shall make a cash payment therefor upon the basis of the Warrant Price then in effect. 
 12. Charges, Taxes and
Expenses. Subject to the provisions of Section 3(a) related to the payment of transfer taxes, issuance of certificates for shares of Common Stock upon the exercise of this Warrant shall be made without charge to Holder for any United States
or state of the United States documentary stamp tax or other incidental expense with respect to the issuance of such certificate, all of which taxes and expenses shall be paid by Company, and such certificates shall be issued in the name of Holder.

  
 8 

 13. No Shareholder Rights Until Exercise. Except as expressly provided herein, this Warrant does not
entitle Holder to any voting rights or other rights as a shareholder of Company prior to the exercise hereof. 
 14. Registry of Warrant.
Company shall maintain a registry showing the name and address of the registered Holder of this Warrant. This Warrant may be surrendered for exchange or exercise, in accordance with its terms, at such office or agency of Company, and Company and
Holder shall be entitled to rely in all respects, prior to written notice to the contrary, upon such registry. 
 15. Loss, Theft,
Destruction or Mutilation of Warrant. Upon receipt by Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant, and, in the case of loss, theft, or destruction, upon delivery of an indemnity
reasonably satisfactory to Company in form and amount, and, if mutilated, upon surrender and cancellation of this Warrant, Company will execute and deliver a new Warrant, having terms and conditions substantially identical to this Warrant, in lieu
hereof. 
 16. Miscellaneous. 
 (a) Issue Date. The provisions of this Warrant shall be construed and shall be given effect in all respect as if it had been issued and delivered by Company on the date hereof. 

(b) Successors. This Warrant shall be binding upon any successors or assigns of Company. 

(c) Headings. The headings used in this Warrant are used for convenience only and are not to be considered in construing or
interpreting this Warrant. 
 (d) Saturdays, Sundays, Holidays. If the last or appointed day for the taking of any action
or the expiration of any right required or granted herein shall be a Saturday or a Sunday or shall be a legal holiday in the State of New York, then such action may be taken or such right may be exercised on the next succeeding day that is not a
legal holiday. 
 (e) Attorney’s Fees. In the event of any dispute between the parties concerning the terms and
provisions of this Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorney’s fees. 

(f) Amendment and Waiver. Any term or provision of this Warrant may be amended or modified, and any term or provision hereof may be
waived (either generally or in a particular instance and either retroactively or prospectively) upon the written consent of Company and Holder. No waivers of any term, condition or provision of this Warrant, in any one or more instances, shall be
deemed to be, or construed as, a further or continuing waiver of any such term, condition or provision. 
 17. No Impairment. Company
will not, by amendment of its Restated Certificate of Incorporation or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the carrying
out of all such terms and in the taking of all such action as may be necessary or appropriate in order to protect the rights of Holder hereof against impairment. 
 18. Addresses. Any notice required or permitted hereunder shall be in writing and shall be mailed by overnight courier, registered or certified mail, return receipt requested, and postage prepaid,
or otherwise delivered by hand or by messenger, addressed as set forth below, or at such other address as Company or 

  
 9 

 
Holder hereof shall have furnished to the other party in accordance with the delivery instructions set forth in this Section 18. 

 

			
	 If to Company:
	 	BG Medicine, Inc.
		 	610 Lincoln Street North
		 	Waltham, Massachusetts 02451
		 	Attn: Chief Financial Officer
		
	 If to Holder:
	 	Comerica Ventures Incorporated
		 	Attn: Warrant Administrator
		 	1717 Main Street, 5th Floor, MC 6406
		 	Dallas, Texas 75201
		 	Facsimile No. (214) 462-4459

 If mailed by registered or certified mail, return receipt requested, and postage prepaid, notice shall be
deemed to be given five (5) days after being sent, and if sent by overnight courier, by hand or by messenger, notice shall be deemed to be given when delivered (if on a business day, and if not, on the next business day). 

19. WAIVER OF JURY TRIAL. EACH OF THE PARTIES HERETO HEREBY WAIVES TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A
TRIAL BY JURY IN RESPECT OF ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS WARRANT OR THE WARRANT SHARES. 
 20. GOVERNING LAW. THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 [Remainder of page intentionally left blank] 

  
 10 

 IN WITNESS WHEREOF, Company has caused this Warrant to be executed by its officer thereunto
duly authorized. 
  

			
	BG MEDICINE, INC.
		
	By:	 	/s/ Michael W. Rogers
		 	Name: Michael W. Rogers
		 	Title: CFO & EVP

 Dated as of: February 10, 2012 

 NOTICE OF EXERCISE 
 To: 
 BG Medicine, Inc. 
 610 Lincoln Street North 
 Waltham, Massachusetts 02451 

Attn: Chief Financial Officer 
  

	1.	The undersigned Warrantholder (“Holder”) elects to acquire shares of the Common Stock (the “Common Stock”) of BG MEDICINE, INC. (the
“Company”), pursuant to the terms of the Stock Purchase Warrant No. CS-10FEB12-2 dated February 10, 2012 (the “Warrant”). 

  

	2.	Holder exercises its rights under the Warrant as set forth below: 

  

			
	 (            )
	 	Holder elects to purchase             shares of Common Stock as provided in Section 3(a) and tenders herewith a
check in the amount of $            as payment of the purchase price.

  

	3.	Holder surrenders the Warrant with this Notice of Exercise. 

 Holder represents that (i) it is acquiring the aforesaid shares of Common Stock for investment and not with a view to or for resale in connection with distribution, (ii) it has no present
intention of distributing or reselling the shares and (iii) it has not engaged in any short sales of Common Stock during the 12 month period preceding the date of this Notice of Exercise. 

.Please issue a certificate representing the shares of the Common Stock in the name of Holder or in such other name as is specified below: 

 

					
			
	 Name:
	 	 	 	
			
	 Address:
	 	 	 	
			
	 Taxpayer I.D.:
	 	 	 	

  

			
	[NAME OF HOLDER]
		
	By:	 	 
		 	Name:
		 	Title:
	
	Date:             ,
20            

 ANNEX A 
 FORM OF CAPITALIZATION TABLE

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