Document:

<PAGE>
                                 EXHIBIT NO. 4.5

                         PROPOSED FORM OF DEBT SECURITY

<PAGE>

                               (FACE OF SECURITY)

REGISTERED                                                         REGISTERED

No._______                                                         $___________

                                      CUSIP

                       SEE REVERSE FOR CERTAIN DEFINITIONS

                           THE PROGRESSIVE CORPORATION

                      ____% [NOTE] [DEBENTURE] DUE _______

          THE PROGRESSIVE CORPORATION, an Ohio corporation (the "Issuer"), for
value received, hereby promises to pay to

or registered assigns, at the office or agency of the Issuer at the office of
the Trustee in Boston, Massachusetts, the principal sum of ______ dollars on
______, ___, in such coin or currency of the United States of America as at the
time of payment shall be legal tender for the payment of public and private
debts, and to pay interest semiannually on _____ and ____ of each year,
commencing on ______, ___, on said principal sum at said office or agency, in
like coin or currency, at the rate per annum specified in the title of this
____, from the _____ or the _____, as the case may be, next preceding the date
of this _____ to which interest has been paid, unless the date hereof is a date
to which interest has been paid, in which case from the date of this _____, or
unless no interest has been paid on this _____, in which case from _____, __,
until payment of said principal sum has been made or duly provided for;
provided, that payment of interest may be made at the option of the Issuer by
check mailed to the address of the person entitled thereto as such address shall
appear on the Security Register. Notwithstanding the foregoing, if the date
hereof is after the ____ day of ______ or ______, as the case may be, and before
the following _____ or _____, this ____ shall bear interest from such ______ or
______; provided, that if the Issuer shall default in the payment of interest
due on such _____ then this ______ shall bear interest from the next preceding
_____ or _____ to which interest has been paid or, if no interest has been paid
on this _____, from ______, ___. The interest so payable on any _____ or _____
will, subject to certain exceptions provided in the Indenture referred to on the
reverse hereof, be paid to the person in whose name this _____ is registered at
the close of business on the ______ or ______, as the case may be, next
preceding such ______ or ______.

         Reference is made to the further provisions of this _____ set forth on
the reverse hereof. Such further provisions shall for all purposes have the same
effect as though fully set forth at this place.

<PAGE>

         This _____ shall not be valid or become obligatory for any purpose
until the certificate of authentication hereon shall have been signed by the
Trustee under the Indenture referred to on the reverse hereof.

         IN WITNESS WHEREOF, The Progressive Corporation has caused this
instrument to be signed by facsimile by its duly authorized officers and has
caused a facsimile of its corporate seal to be affixed hereto or imprinted
hereon.

                                          THE PROGRESSIVE CORPORATION

(CORPORATE SEAL)                          By:
                                          President and Chief Executive Officer

Attest:

                                   Secretary

Dated:

                     TRUSTEE'S CERTIFICATE OF AUTHENTICATION

         This is one of the Securities, of the series designated herein,
referred to in the within-mentioned Indenture.

                                          STATE STREET BANK AND TRUST COMPANY
                                                     as Trustee

                                          By:
                                          Authorized Signatory

                                       2
<PAGE>

                               (BACK OF SECURITY)

                           THE PROGRESSIVE CORPORATION

                             ____% ______ DUE _____

         This _______ is one of a duly authorized issue of debentures, notes,
bonds or other evidences of indebtedness of the Issuer (herein called the
"Securities") of the series hereinafter specified, all issued or to be issued
under and pursuant to an indenture dated as of September 15, 1993, as heretofore
supplemented and amended (herein called the "Indenture"), between the Issuer and
State Street Bank and Trust Company, as Trustee (herein called the "Trustee"),
to which Indenture and all indentures supplemental thereto reference is hereby
made for a description of the rights, limitations of rights, obligations, duties
and immunities thereunder of the Trustee, the Issuer and the Holders of the
Securities. The Securities may be issued in one or more series, which different
series may be issued in various aggregate principal amounts, may mature at
different times, may bear interest (if any) at different rates, may be subject
to different redemption provisions (if any), may be subject to different
sinking, purchase or analogous funds (if any) and may otherwise vary as in the
Indenture provided. This ______ is one of a series designated as the ___% _____
Due _____ of the Issuer, limited in initial aggregate principal amount to
$________.

         In case an Event of Default, as defined in the Indenture, with respect
to the ___% ______ Due ________ shall have occurred and be continuing, the
principal hereof may be declared, and upon such declaration shall become, due
and payable, in the manner, with the effect and subject to the conditions
provided in the Indenture.

         The Indenture contains provisions permitting the Issuer and the
Trustee, with the consent of the Holders of not less than 66 2/3 % in aggregate
principal amount of the Securities at the time Outstanding (as defined in the
Indenture) of all series to be affected (voting as one class), evidenced as in
the Indenture provided, to execute supplemental indentures adding any provisions
to or changing in any manner or eliminating any of the provisions of the
Indenture or of any supplemental indenture or modifying in any manner the rights
of the Holders of the Securities of each such series; provided, however, that no
such supplemental indenture shall (i) extend the final maturity of any Security,
or reduce the principal amount thereof, or reduce the rate or extend the time of
payment of any interest thereon, or impair or affect the rights of any Holder to
institute suit for the payment thereof, without the consent of the Holder of
each Security so affected or (ii) reduce the aforesaid percentage of Securities,
the Holders of which are required to consent to any such supplemental indenture,
without the consent of the Holder of each security so affected. It is also
provided in the Indenture that, with respect to certain defaults or Events of
Default regarding the Securities of any series, prior to any declaration
accelerating the maturity of such Securities, the Holders of a majority in
aggregate principal amount Outstanding of the Securities of such series may on
behalf of the Holders of all the Securities of such series waive any such past
default or Event of Default and its consequences. The preceding sentence shall
not, however, apply to a default in the payment of the principal of or premium,
if any, or interest on any of the Securities. Any such consent or waiver by the
Holder of this _______ (unless revoked as provided in the Indenture) shall be
conclusive and binding upon such Holder and upon all future Holders and owners
of this ______ and any ________ which may be issued in exchange or substitution
herefor, irrespective of whether or not any notation thereof is made upon this
_______ or such other ______.

         No reference herein to the Indenture and no provision of this ______ or
of the Indenture shall alter or impair the obligation of the Issuer, which is
absolute and unconditional, to pay the principal of and interest on this
________ in the manner, at the respective times, at the rate and in the coin or
currency herein prescribed.

         The ________ are issuable in registered form without coupons in
denominations of $1,000 and any integral multiple of $1,000 at the office or
agency of the Issuer at the office of the Trustee in Boston, Massachusetts, and
in the manner and subject to the limitations provided in the Indenture, but
without the payment of any service charge. ______ may be exchanged for a like
aggregate principal amount of _______ of other authorized denominations.

         [The ________ are not subject to redemption at the option of the Issuer
or through the operation of a sinking fund.]

<PAGE>

         Upon due presentment for registration of transfer of this _______ at
the office or agency of the Issuer at the office of the Trustee in Boston,
Massachusetts, a new _______ or _______ of authorized denominations for an equal
aggregate principal amount will be issued to the transferee in exchange
therefor, subject to the limitations provided in the Indenture, without charge
except for any tax or other governmental charge imposed in connection therewith.

         The Issuer, the Trustee and any authorized agent of the Issuer or the
Trustee may deem and treat the registered Holder hereof as the absolute owner of
this ______ (whether or not this _____ shall be overdue and notwithstanding any
notation of ownership or other writing hereon), for the purpose of receiving
payment of, or on account of, the principal hereof and, subject to the
provisions on the face hereof, interest hereon, and for all other purposes, and
neither the Issuer nor the Trustee nor any authorized agent of the Issuer or the
Trustee shall be affected by notice to the contrary.

         No recourse under or upon any obligation, covenant or agreement of the
Issuer in the Indenture or any indenture supplemental thereto or in any _______,
or because of the creation of any indebtedness represented thereby, shall be had
against any incorporator, shareholder, officer or director, as such, of the
Issuer or of any successor corporation, either directly or through the Issuer or
any successor corporation, under any rule of law, statute or constitutional
provision or by the enforcement of any assessment or by any legal or equitable
proceeding or otherwise, all such liability being expressly waived and released
by the acceptance hereof and as part of the consideration for the issue hereof.

         Terms used herein which are defined in the Indenture shall have the
respective meanings assigned thereto in the Indenture.

<PAGE>

                                  ABBREVIATIONS

         The following abbreviations, when used in the inscription on the face
of this instrument, shall be construed as though they were written out in full
according to applicable laws or regulations:

<TABLE>
<S>        <C> <C>                                    <C>                  <C>  <C>
TEN COM    -   as tenants in common
TEN ENT    -   as tenants by the entireties           CUST                 -    Custodian
JT TEN     -   as joint tenants with right of
               survivorship and not as tenants        UNIF GIFT MIN ACT    -    Uniform Gifts
               in common                                                        to Minors Act
                                                                                ------------
                                                                                  (State)
</TABLE>

          Additional abbreviations may also be used though not in the above
list.

                              ---------------------

FOR VALUE RECEIVED the undersigned hereby sell(s), assign(s) and transfers unto

PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE

________________________________________________________________________________
              Please print or typewrite name and address including
                           postal zip code of assignee

________________________________________________________________________________
the within       and all rights thereunder, hereby irrevocably constituting

and appointing

___________________________ attorney to transfer said on the

books of the Issuer, with full power of substitution in the premises.

Dated:______________________
                                              __________________________________
                                              NOTICE: The signature to
                                              this assignment must
                                              correspond with the name as
                                              written upon the face of
                                              the within instrument in
                                              every particular, without
                                              alteration or enlargement
                                              or any change whatever.RIGHTS AGREEMENT

 EXHIBIT 4.1 
  
  
  
 RIGHTS AGREEMENT 
  
 BY AND BETWEEN 
  
 INSPIRE PHARMACEUTICALS, INC. 
  
 AND 
  
 COMPUTERSHARE TRUST COMPANY 
  
 AS RIGHTS AGENT 
  
 DATED AS OF 
  
 OCTOBER 21, 2002 

  
 TABLE OF CONTENTS 
  
 
	  	  	  	  	 PAGE
 

	 Section 1.
 	  	 
CERTAIN DEFINITIONS
 	  	 1
 
	 Section 2.
 	  	 
APPOINTMENT OF RIGHTS AGENT 
 	  	 5
 
	 Section 3.
 	  	 
ISSUE OF RIGHTS CERTIFICATES 
 	  	 5
 
	 Section 4.
 	  	 
FORM OF RIGHTS CERTIFICATES 
 	  	 7
 
	 Section 5.
 	  	 
COUNTERSIGNATURE AND REGISTRATION 
 	  	 7
 
	 Section 6.
 	  	 
TRANSFER, SPLIT-UP, COMBINATION AND EXCHANGE OF RIGHTS CERTIFICATES; MUTILATED, DESTROYED, LOST OR STOLEN RIGHTS CERTIFICATES 
 	  	 7
 
	 Section 7.
 	  	 
EXERCISE OF RIGHTS; PURCHASE PRICE; EXPIRATION DATE OF RIGHTS 
 	  	 8
 
	 Section 8.
 	  	 
CANCELLATION AND DESTRUCTION OF RIGHTS CERTIFICATES 
 	  	 10
 
	 Section 9.
 	  	 
RESERVATION AND AVAILABILITY OF PREFERRED STOCK 
 	  	 10
 
	 Section 10.
 	  	 
PREFERRED STOCK RECORD DATE 
 	  	 11
 
	 Section 11.
 	  	 
ADJUSTMENT OF PURCHASE PRICE, NUMBER OF SHARES OR NUMBER OF RIGHTS 
 	  	 12
 
	 Section 12.
 	  	 
CERTIFICATE OF ADJUSTED PURCHASE PRICE OR NUMBER OF SHARES 
 	  	 19
 
	 Section 13.
 	  	 
CONSOLIDATION, MERGER OR SALE OR TRANSFER OF ASSETS OR EARNING POWER 
 	  	 20
 
	 Section 14.
 	  	 
FRACTIONAL RIGHTS AND FRACTIONAL SHARES 
 	  	 22
 
	 Section 15.
 	  	 
RIGHTS OF ACTION 
 	  	 23
 
	 Section 16.
 	  	 
AGREEMENT OF RIGHTS HOLDERS 
 	  	 24
 
	 Section 17.
 	  	 
RIGHTS CERTIFICATE HOLDER NOT DEEMED A STOCKHOLDER 
 	  	 24
 
	 Section 18.
 	  	 
CONCERNING THE RIGHTS AGENT 
 	  	 25
 
	 Section 19.
 	  	 
MERGER OR CONSOLIDATION OR CHANGE OF NAME OF RIGHTS AGENT 
 	  	 25
 
	 Section 20.
 	  	 
DUTIES OF RIGHTS AGENT 
 	  	 26
 
	 Section 21.
 	  	 
CHANGE OF RIGHTS AGENT 
 	  	 28
 
	 Section 22.
 	  	 
ISSUANCE OF NEW RIGHTS CERTIFICATES 
 	  	 28
 
	 Section 23.
 	  	 
REDEMPTION AND TERMINATION 
 	  	 29
 
	 Section 24.
 	  	 
EXCHANGE 
 	  	 30
 

 

 
 i 

  
 
	 Section 25.
 	  	 
NOTICE OF CERTAIN EVENTS 
 	  	 31
 
	 Section 26.
 	  	 
NOTICES 
 	  	 32
 
	 Section 27.
 	  	 
SUPPLEMENTS AND AMENDMENTS 
 	  	 32
 
	 Section 28.
 	  	 
SUCCESSORS 
 	  	 33
 
	 Section 29.
 	  	 
DETERMINATIONS AND ACTIONS BY THE BOARD OF DIRECTORS 
 	  	 33
 
	 Section 30.
 	  	 
BENEFITS OF THIS AGREEMENT 
 	  	 33
 
	 Section 31.
 	  	 
SEVERABILITY 
 	  	 33
 
	 Section 32.
 	  	 
GOVERNING LAW 
 	  	 34
 
	 Section 33.
 	  	 
COUNTERPARTS 
 	  	 34
 
	 Section 34.
 	  	 
DESCRIPTIVE HEADINGS 
 	  	 34
 

 

 
 ii 

  
 EXHIBITS 
  
  
 
	 Exhibit A
 	  	 Form of Certificate of Designation of Series H Preferred Stock
 
	 
	 Exhibit B
 	  	 Form of Rights Certificate
 
	 
	 Exhibit C
 	  	 Summary of Rights to Purchase Shares of Series H Preferred Stock
 

 
  

 
 iii 

 RIGHTS AGREEMENT 
  
 RIGHTS AGREEMENT, dated as of October 21, 2002 (this “AGREEMENT”), by and between Inspire Pharmaceuticals, Inc., a Delaware corporation (the “COMPANY”), and Computershare Trust
Company (the “RIGHTS AGENT”). 
  
 WHEREAS, the Board of Directors of the Company authorized and declared a
distribution of one Right (each, a “RIGHT”) for each share of Common Stock (as hereinafter defined) of the Company outstanding as of the Close of Business (as hereinafter defined) on November 4, 2002 (the “RECORD DATE”), each
Right initially representing the right to purchase one one-thousandth of a share of (a “UNIT”) Preferred Stock (as hereinafter defined) upon the terms and subject to the conditions herein set forth, and has further authorized and directed
the issuance of one Right with respect to each share of Common Stock of the Company that shall become outstanding between the Record Date and the earliest of the Distribution Date, the Redemption Date and the Final Expiration Date (as such terms are
hereinafter defined). 
  
 NOW, THEREFORE, in consideration of the foregoing and the mutual agreements herein set
forth, the parties hereto, intending to be legally bound, hereby agree as follows: 
  
 
Section 1.    CERTAIN DEFINITIONS.    For purposes of this Agreement, the following terms have the meanings indicated: 
  
 “ACQUIRING PERSON” shall mean any Person (as such term is hereinafter defined) who or which, together with all Affiliates and Associates (as such terms are
hereinafter defined) of such Person, shall be the Beneficial Owner (as such term is hereinafter defined) of 15% or more of the shares of Common Stock of the Company then outstanding, but shall not include (1) the Company, any Subsidiary (as such
term is hereinafter defined) of the Company, any employee benefit plan of the Company or any Subsidiary of the Company, or any entity holding shares of Common Stock of the Company for or pursuant to the terms of any such plan. Notwithstanding the
foregoing: 
  
 (i)  no Person shall become an “Acquiring Person” as the result of
an acquisition of shares of Common Stock by the Company which, by reducing the number of shares outstanding, increases the proportionate number of shares beneficially owned by such Person to 15% or more of the shares of Common Stock of the Company
then outstanding; 
  
 PROVIDED, however, that if a Person shall become the Beneficial Owner of 15% or more of the shares of Common Stock of
the Company and shall, after such acquisition of shares by the Company, become the Beneficial Owner of any additional shares of Common Stock of the Company (other than as a result of a stock dividend, stock split or similar transaction effected by
the Company in which all holders of Common Stock of the Company are treated equally) (or, in the case of the members of the Investor Group, become the Beneficial Owner of any additional shares of Common Stock of the Company), then such Person shall
be deemed to be an “Acquiring Person” hereunder; and 

 
 1 

  
 (ii)  if the Board of Directors of the Company
determines in good faith that a Person who would otherwise be an “Acquiring Person” as defined pursuant to the provisions of subparagraph (i), has become such inadvertently, and such Person divests as promptly as practicable a sufficient
number of shares of Common Stock of the Company so that such Person would no longer be an “Acquiring Person, then such Person shall not be deemed to be an “Acquiring Person” for any purpose of this Agreement. 
  
 “ADJUSTMENT SHARES” shall have the meaning set forth in Section 11(a)(ii). 
  

“AFFILIATE” and “ASSOCIATE” shall have the respective meanings ascribed to such terms in Rule 12b-2 of the Exchange Act Regulations (as hereinafter
defined) as in effect on the date of this Agreement. 
  
 “BENEFICIAL OWNER” shall mean a Person who shall
be deemed the “beneficial owner” of, and shall be deemed to “beneficially own,” any securities: 
  
 (A)  which such Person or any of such Person’s Affiliates or Associates beneficially owns, directly or indirectly, for purposes of Section 13(d) of the Exchange Act (as hereinafter defined) and Rule 13d-3
thereunder (or any comparable or successor law or regulation); and 
  
 (B)  which such
Person or any of such Person’s Affiliates or Associates, directly or indirectly, has (A) the right to acquire (whether such right is exercisable immediately, contingently or only after the passage of time) pursuant to any agreement, arrangement
or understanding (whether or not in writing, other than customary agreements with and between underwriters and selling group members with respect to a bona fide public offering of securities), or upon the exercise of conversion rights, exchange
rights, rights (other than the Rights), warrants or options, or otherwise; PROVIDED, HOWEVER, that a Person shall not be deemed the Beneficial Owner of, or to beneficially own, securities tendered pursuant to a tender or exchange offer made by or on
behalf of such Person or any of such Person’s Affiliates or Associates until such tendered securities are accepted for purchase or exchange; or (B) the right to vote pursuant to any agreement, arrangement or understanding; PROVIDED FURTHER,
HOWEVER, that a Person shall not be deemed the “Beneficial Owner” of, or to “beneficially own,” any security under this subparagraph (ii) as a result of an agreement, arrangement or understanding to vote such security if such
agreement, arrangement or understanding: (x) arises solely from a revocable proxy given in response to a public proxy or consent solicitation made pursuant to, and in accordance with, the applicable provisions of the Exchange Act and the Exchange
Act Regulations, and (y) is not reportable by such Person on Schedule 13D under the Exchange Act (or any comparable or successor report); and 
  
 (C)  which are beneficially owned, directly or indirectly, by any other Person (or any Affiliate or Associate thereof) with which such Person (or any of such Person’s Affiliates or
Associates) has any agreement, arrangement or understanding (whether or not in writing, other than customary agreements with and between underwriters and selling group members with respect to a bona fide public offering of securities), for the
purpose of acquiring, holding, voting (except to the extent contemplated by the proviso to clause (B) of subparagraph (ii) above) or disposing of any securities of the Company; PROVIDED, HOWEVER, that in no 

 
 2 

  
 case shall an officer or director of the Company be deemed (A) the Beneficial Owner of any securities
beneficially owned by another officer or director of the Company solely by reason of actions undertaken by such persons in their capacity as officers or directors of the Company or (B) the Beneficial Owner of securities held of record by the trustee
of any employee benefit plan of the Company or any Subsidiary of the Company for the benefit of any employee of the Company or any Subsidiary of the Company, other than such officer or director, by reason of any influence that such officer or
director may have over the voting of the securities held in the plan; 
  
 Notwithstanding anything in this definition of “Beneficial
Owner” and “beneficially own” to the contrary, the phrase “then outstanding,” when used with reference to a Person who is the Beneficial Owner of securities of the Company, shall mean the number of such securities then
issued and outstanding together with the number of such securities not then actually issued and outstanding which such Person would be deemed to beneficially own hereunder. 
  
 “BUSINESS DAY” shall mean any day other than a Saturday, a Sunday, or a day on which banking institutions in The City of New York are authorized or obligated by
law or executive order to close. 
  
 “CLOSE OF BUSINESS” on any given date shall mean 5:00 P.M., New York
City time, on such date; PROVIDED, HOWEVER, that if such date is not a Business Day it shall mean 5:00 P.M., New York City time, on the next succeeding Business Day. 
  
 “COMMON STOCK” when used with reference to the Company shall mean the shares of common stock, par value $.001, of the Company. “Common Stock” when used
with reference to any Person other than the Company shall mean the capital stock (or other equity interest) with the greatest voting power of such other Person or, if such other Person is a Subsidiary of another Person, the Person or Persons which
ultimately controls such first-mentioned Person. 
  
 “COMPANY” shall have the meaning set forth in the
forepart of this Agreement and Section 13(a), as applicable. 
  
 “CURRENT PER SHARE MARKET PRICE” shall
have the meaning set forth in Sections 11(d)(i) and 11(d)(ii). 
  
 “CURRENT VALUE” shall have the meaning
set forth in Section 11(a)(iii). 
  
 “DISTRIBUTION DATE” shall have the meaning set forth in Section 3(a).

  
 “EQUIVALENT PREFERRED STOCK” shall have the meaning set forth in Section 11(b). 

 
 “EXCHANGE ACT” shall mean the Securities Exchange Act of 1934, as amended, or any successor statute. 

 
 “EXCHANGE ACT REGULATIONS” shall mean the Rules and Regulations under the Exchange Act, as amended from time to time
(including any successor rules). 

 
 3 

  
 “EXCHANGE RATIO” shall have the meaning set forth in Section 24.

  
 “EXPIRATION DATE” shall have the meaning set forth in Section 7(a). 
  
 “FINAL EXPIRATION DATE” shall have the meaning set forth in Section 7(a). 
  

“NASDAQ” shall have the meaning set forth in Section 11(d). 
  
 “PERSON” shall mean any individual, firm, corporation or other entity, and shall include any successor (by merger or otherwise) of such entity. 
  
 “PREFERRED STOCK” shall mean shares of Series H Preferred Stock, par value $.001, of the Company having the rights and
preferences set forth in the Form of Certificate of Designation attached to this Agreement as Exhibit A. 
  
 “PREFERRED STOCK EQUIVALENTS” shall have the meaning set forth in Section 11(a)(iii). 
  
 “PRINCIPAL PARTY” shall have the meaning set forth in Section 13. 
  
 “PURCHASE
PRICE” shall have the meaning set forth in Section 7(b) and Section 13(a), as applicable. 
  
 “RECORD
DATE” shall have the meaning set forth in the recitals to this Agreement. 
  
 “REDEMPTION DATE” shall
have the meaning set forth in Section 7(a). 
  
 “REDEMPTION PRICE” shall have the meaning set forth in
Section 23(a). 
  
 “REGISTERED COMMON STOCK” shall have the meaning set forth in Section 13. 

 
 “RIGHT” shall have the meaning set forth in the recitals to this Agreement. 
  
 “RIGHTS AGENT” shall have the meaning set forth in the forepart of this Agreement and shall include any Person that shall become
a successor Rights Agent pursuant to the terms of this Agreement. 
  
 “RIGHTS CERTIFICATE” shall have the
meaning set forth in Section 3(a). 
  
 “SECTION 11(a)(ii) EVENT” shall mean any event described in Section
11(a)(ii)(A), (B) or (C). 
  
 “SECTION 11(a)(iii) TRIGGER DATE” shall have the meaning set forth in Section
11(a)(iii). 

 
 4 

  
 “SECTION 13 EVENT” shall mean any event described in clause (x), (y) or
(z) of Section 13(a). 
  
 “SECURITIES ACT” shall mean the Securities Act of 1933, as amended, or any
successor statute. 
  
 “SHARE ACQUISITION DATE” shall mean the first date of public announcement (which,
for purposes of this definition, shall include, without limitation, a report filed pursuant to Section 13(d) of the Exchange Act) by the Company or an Acquiring Person that an Acquiring Person has become such. 
  
 “SPREAD” shall have the meaning set forth in Section 11(a)(iii). 
  
 “SUBSIDIARY” of any Person shall mean any corporation or other entity of which a majority of the voting power of the voting equity securities or equity interest
is owned, directly or indirectly, by such Person. 
  
 “SUMMARY OF RIGHTS” shall have the meaning set forth
in Section 3(b). 
  
 “TRADING DAY” shall have the meaning set forth in Section 11(d)(i). 

 
 “TRIGGERING EVENT” shall mean any Section 11(a)(ii) Event or any Section 13 Event. 
  
 “UNIT” shall have the meaning set forth in the recitals to this Agreement. 
  

Section 2.    APPOINTMENT OF RIGHTS AGENT.    The Company hereby appoints the Rights Agent to act as agent for the Company in accordance with the terms and conditions of this Agreement,
and the Rights Agent hereby accepts such appointment. The Company may from time to time appoint co-Rights Agents as it may deem necessary or desirable upon ten days prior written notice to the Rights Agent. The Rights Agent shall have no duty to
supervise, and shall in no event be liable for, the acts or omissions of any such co-Rights agent. 
  
 
Section 3.    ISSUE OF RIGHTS CERTIFICATES. 
  
 (a)  Until the earlier of (i) the Close of Business on the tenth (10th) day after the Share Acquisition Date and (ii) the Close of Business on the tenth Business Day (or such later date as may be determined by action of the
Company’s Board of Directors prior to such time as any Person becomes an Acquiring Person and of which the Company will give the Rights Agent prompt written notice) after the date that a tender or exchange offer by any Person (other than the
Company, any Subsidiary of the Company, any employee benefit plan of the Company or of any Subsidiary of the Company or any entity holding shares of Common Stock for or pursuant to the terms of any such plan) is commenced within the meaning of Rule
14d-4(a) of the Exchange Act Regulations, if upon consummation thereof such Person would be the Beneficial Owner of 15% or more of the shares of Common Stock of the Company then outstanding (the earlier of (i) and (ii) above being the
“DISTRIBUTION DATE”), (x) the Rights will be evidenced (subject to the provisions of Section 3(b)) by the certificates for shares of 

 
 5 

 Common Stock of the Company registered in the names of the holders thereof (which certificates shall also be deemed to be
Rights Certificates) and not by separate Rights Certificates, and (y) the right to receive Rights Certificates will be transferable only in connection with the transfer of shares of Common Stock of the Company. As soon as practicable after the
Distribution Date, the Company will notify the Rights Agent of the occurrence of the Distribution Date and the Company will prepare and execute, the Rights Agent will countersign, and the Company will send or cause to be sent (and the Rights Agent
will, if requested, send) by first-class, insured, postage-prepaid mail, to each record holder of shares of Common Stock of the Company as of the Close of Business on the Distribution Date, at the address of such holder shown on the records of the
Company, a Rights Certificate, in substantially the form of EXHIBIT B (a “RIGHTS CERTIFICATE”), evidencing one Right for each share of Common Stock so held. From and after the Distribution Date, the Rights will be evidenced solely by such
Rights Certificates. 
  
 (b) On the Record Date, or as soon as practicable thereafter, the Company
will send a copy of a Summary of Rights to Purchase Preferred Stock, in substantially the form of EXHIBIT C (the “SUMMARY OF RIGHTS”), by first-class, postage-prepaid mail, to each record holder of shares of Common Stock of the Company as
of the Close of Business on the Record Date, at the address of such holder shown on the records of the Company. Until the Distribution Date (or the Expiration Date), the surrender for transfer of any certificate for shares of Common Stock of the
Company outstanding on the Record Date shall also constitute the transfer of the Rights associated with the shares of Common Stock represented thereby. 
  
 (c) Rights will be issued by the Company in respect of all Common Shares (other than Common Shares issued upon the exercise or exchange of any Right) issued
or delivered by the Company (whether originally issued or delivered from the Company’s treasury) after the Record Date but prior to the earlier of the Distribution Date and the Expiration Date. Certificates for such shares of Common Stock shall
have impressed on, printed on, written on or otherwise affixed to them the following legend (or such other legend as the Company may deem appropriate that is not inconsistent with the provisions of this Agreement): 
  
 This certificate also evidences and entitles the holder hereof to certain rights as set forth in a Rights Agreement between Inspire
Pharmaceuticals, Inc. and Computershare Trust Company dated as of October 21, 2002 (the “Rights Agreement”), the terms of which are hereby incorporated herein by reference and a copy of which is on file at the principal executive offices
of Inspire Pharmaceuticals, Inc. Under certain circumstances, as set forth in the Rights Agreement, such Rights will be evidenced by separate certificates and will no longer be evidenced by this certificate. Inspire Pharmaceuticals, Inc. will mail
to the holder of this certificate a copy of the Rights Agreement without charge after receipt of a written request therefor. Under certain circumstances, as set forth in the Rights Agreement, Rights issued to any Person who becomes an Acquiring
Person (as defined in the Rights Agreement), whether currently held by or on behalf of such person or by any subsequent holder, may become null and void. 
  
 If the Company purchases or acquires any shares of Common Stock of the Company after the Record Date but prior to the Distribution Date, any Rights associated with such shares of 

 
 6 

 Common Stock of the Company shall be deemed cancelled and retired so that the Company shall not be entitled to exercise
any Rights associated with any shares of Common Stock of the Company which are no longer outstanding. 
  
 
Section 4.    FORM OF RIGHTS CERTIFICATES.    The Rights Certificates (and the forms of election to purchase Units and of assignment to be printed on the reverse thereof) shall be
substantially the same as Exhibit B and may have such marks of identification or designation and such legends, summaries or endorsements printed thereon as the Company may deem appropriate and as are not inconsistent with the provisions of this
Agreement, or as may be required to comply with any applicable law or with any rule or regulation made pursuant thereto or with any rule or regulation of any stock exchange or transaction reporting system on which the Rights may from time to time be
listed or traded, or to conform to usage. Subject to the provisions of Sections 11 and 22, the Rights Certificates shall entitle the holders thereof to purchase the number of Units as shall be set forth therein at the price per Unit of Preferred
Stock set forth therein, but the number of such Units and the Purchase Price shall be subject to adjustment as provided herein. 
  
 
Section 5.    COUNTERSIGNATURE AND REGISTRATION. 
  
 (a)  The Rights Certificates shall be executed on behalf of the Company by any officer of the Company, either manually or by facsimile signature, shall have affixed thereto the Company’s seal or a facsimile thereof,
and shall be attested by the Secretary or an Assistant Secretary of the Company, either manually or by facsimile signature. The Rights Certificates shall be countersigned by the Rights Agent and shall not be valid for any purpose unless
countersigned. In case any officer of the Company who shall have signed any of the Rights Certificates shall cease to be such officer of the Company before countersignature by the Rights Agent and issuance and delivery by the Company, such Rights
Certificates, nevertheless, may be countersigned by the Rights Agent and issued and delivered by the Company with the same force and effect as though the person who signed such Rights Certificates had not ceased to be such officer of the Company.
Any Rights Certificate may be signed on behalf of the Company by any Person who, at the actual date of the execution of such Rights Certificate, shall be a proper officer of the Company to sign such Rights Certificate, although at the date of this
Agreement any such Person was not such an officer. 
  
 (b)  Following the Distribution
Date, the Rights Agent will keep or cause to be kept, at its office designated for such purpose, books for registration and transfer of the Rights Certificates issued under this Agreement. Such books shall show the names and addresses of the
respective holders of the Rights Certificates, the number of Rights evidenced on its face by each of the Rights Certificates and the date of each of the Rights Certificates. 
  
 
Section 6.    TRANSFER, SPLIT-UP, COMBINATION AND EXCHANGE OF RIGHTS CERTIFICATES; MUTILATED, DESTROYED, LOST OR STOLEN RIGHTS CERTIFICATES. 
  
 (a)  Subject to the provisions of Sections 4, 7(e) and 14, at any time after the Close of Business on the Distribution Date, and at or prior to
the Close of Business on the Expiration Date, any Rights Certificate or Rights Certificates may be transferred, split up, 

 
 7 

 combined or exchanged for another Rights Certificate or Rights Certificates evidencing exercisable Rights, entitling the
registered holder to purchase a like number of Units (or, following a Triggering Event, other securities, cash or other assets, as the case may be) as the Rights Certificate or Rights Certificates surrendered then entitled such holder to purchase.
Any registered holder desiring to transfer, split up, combine or exchange any Rights Certificate or Rights Certificates shall make such request in writing delivered to the Rights Agent, and shall surrender the Rights Certificate or Rights
Certificates to be transferred, split up, combined or exchanged at the office of the Rights Agent designated for such purpose. Neither the Rights Agent nor the Company shall be obligated to take any action whatsoever with respect to the transfer of
any such surrendered Rights Certificate until the registered holder shall have completed and signed the certificate contained in the form of assignment on the reverse side of such Rights Certificate and shall have provided such additional evidence
of the identity of the Beneficial Owner (or former Beneficial Owner) or Affiliates or Associates thereof as the Company shall reasonably request. Thereupon the Rights Agent shall, subject to Sections 4(b), 7(e) and 14, countersign and deliver to the
Person entitled thereto a Rights Certificate or Rights Certificates, as the case may be, as so requested. The Company may require payment of a sum sufficient to cover any tax or governmental charge that may be imposed in connection with any
transfer, split up, combination or exchange of Rights Certificates. 
  
 (b)  Upon receipt
by the Company and the Rights Agent of evidence reasonably satisfactory to them of the loss, theft, destruction or mutilation of a Rights Certificate, and of indemnity or security reasonably satisfactory to them, and, at the Company’s request,
reimbursement to the Company and the Rights Agent of all reasonable expenses incidental thereto, and upon surrender to the Rights Agent and cancellation of the Rights Certificate if mutilated, the Company will make and deliver a new Rights
Certificate of like tenor to the Rights Agent for delivery to the registered holder in lieu of the Rights Certificate so lost, stolen, destroyed or mutilated. 
  
 
Section 7.    EXERCISE OF RIGHTS; PURCHASE PRICE; EXPIRATION DATE OF RIGHTS. 
  
 (a)  The registered holder of any Rights Certificate evidencing exercisable Rights may exercise the Rights evidenced thereby (except as otherwise provided in this Agreement) in whole or in part at any time after
the Distribution Date upon surrender of the Rights Certificate, with the form of election to purchase and the related certification duly executed, to the Rights Agent at the office of the Rights Agent designated for such purpose, together with
payment of the Purchase Price for each Right being exercised (as such amount may be reduced (including to zero) pursuant to Section 11(a)(iii)) and an amount equal to any applicable transfer tax required to be paid by the holder of such Rights
Certificate in accordance with Section 9 in cash, or by certified check, wire transfer or bank draft payable to the order of the Company), at or prior to the earliest of (i) the Close of Business on the tenth (10th) anniversary of the Distribution
Date (the “FINAL EXPIRATION DATE”), (ii) the time at which the Rights are redeemed as provided in Section 23 (the “REDEMPTION DATE”), and (iii) the time at which such Rights are exchanged as provided in Section 24 (the earliest
of (i), (ii) and (iii) being the “EXPIRATION DATE”). 

 
 8 

  
 (b) The Purchase Price for each Unit of Preferred Stock pursuant
to the exercise of a Right shall initially be $50.00, shall be subject to adjustment from time to time as provided in Sections 11 and 13, and shall be payable in lawful money of the United States of America in accordance with paragraph (c) below
(the “Purchase Price”). 
  
 (c) Upon receipt of a Rights Certificate evidencing exercisable
Rights (with the form of election to purchase duly executed) accompanied by payment as provided in Section 7(a), the Rights Agent shall, subject to Section 20(k), thereupon promptly (i) (A) requisition from any transfer agent of the Preferred Stock
a certificate or certificates for the number of Units to be purchased and the Company hereby irrevocably authorizes its transfer agent to comply with all such requests or (B) if the Company shall have elected to deposit the total number of Units
issuable upon exercise of the Rights hereunder with a depositary agent, requisition from the depositary agent of a depositary receipt or depositary receipts representing such number of Units as are to be purchased (in which case certificates for the
Units represented by such receipt or receipts shall be deposited by the transfer agent with the depositary agent) and the Company hereby directs the depositary agent to comply with such request; (ii) when appropriate, requisition from the Company
the amount of cash to be paid in lieu of issuance of fractional shares in accordance with Section 14; (iii) after receipt of such certificates or depositary receipts, cause the same to be delivered to or upon the order of the registered holder of
such Rights Certificate, registered in such name or names as may be designated by such holder; and (iv) when appropriate, after receipt thereof, deliver such cash to or upon the order of the registered holder of such Rights Certificate. If the
Company is obligated to issue other securities of the Company, pay cash and/or distribute other property pursuant to Section 11(a), the Company will make all arrangements necessary so that such other securities, cash and/or other property are
available for distribution by the Rights Agent, if and when appropriate. 
  
 (d) If the registered
holder of any Rights Certificate shall exercise less than all the Rights evidenced thereby, a new Rights Certificate evidencing a number of Rights equivalent to the number of Rights remaining unexercised shall be issued by the Rights Agent to the
registered holder of such Rights Certificate or to such registered holder’s duly authorized assigns, subject to Section 14. 
  
 (e) Notwithstanding anything in this Agreement to the contrary, from and after the first occurrence of a Triggering Event, any Rights beneficially owned by (i) an Acquiring Person or an Associate or
Affiliate of an Acquiring Person; (ii) a transferee of an Acquiring Person (or of any such Associate or Affiliate) who becomes a transferee after the Acquiring Person becomes such; (iii) a transferee of an Acquiring Person (or of any such Associate
or Affiliate) who becomes a transferee prior to or concurrently with the Acquiring Person becoming such and receives such Rights pursuant to either (A) a transfer (whether or not for consideration) from the Acquiring Person to holders of equity
interests in such Acquiring Person or to any Person with whom the Acquiring Person has any continuing agreement, arrangement or understanding regarding the transferred Rights or (B) a transfer which the Board of Directors of the Company has
determined is part of a plan, arrangement or understanding which has as a primary purpose or effect the avoidance of this Section 7(e); or (iv) any subsequent transferee, shall become null and void without any further action and no holder of such
Rights shall have any rights whatsoever with respect to such Rights or any Rights Certificate which formerly evidenced such Rights, and neither the Company nor the Rights 

 
 9 

  
 Agent shall have any obligations whatsoever with respect to such Rights or any
Rights Certificate, whether under any provision of this Agreement or otherwise. Without limiting the generality or effect of the immediately preceding sentence, following the occurrence of a Triggering Event, no Right Certificate will be issued
pursuant to Section 3 or Section 6 evidencing Rights that shall have become void pursuant to the provisions of this Section 7(e) and any mistakenly issued Right Certificate shall be void, and any Rights Certificate surrendered to the Company or the
Rights Agent that formerly evidenced Rights that shall have become void pursuant to the foregoing provisions of this Section 7(e) will be canceled without any consideration being payable in respect thereof. Notwithstanding anything to the contrary
contained in this Agreement, neither the Company nor the Rights Agent shall have any liability to any holder of Rights Certificates or to any other Person as a result of its making or failing to make any determinations with respect to an Acquiring
Person or any of such Acquiring Person’s Affiliates, Associates or transferees or taking or failing to take any actions with respect to any Rights or Rights Certificates of any such Person. 
  

(f)  Notwithstanding anything in this Agreement to the contrary, neither the Rights Agent nor the Company shall be obligated to undertake any
action with respect to a registered holder upon the occurrence of any purported exercise as set forth in this Section 7 unless such registered holder shall have (i) completed and signed the certificate contained in the form of election to purchase
set forth on the reverse side of the Rights Certificate surrendered for such exercise and (ii) provided such additional evidence of the identity of the Beneficial Owner (or former Beneficial Owner) or Affiliates or Associates thereof as the Company
shall reasonably request. 
  
 
Section 8.    CANCELLATION AND DESTRUCTION OF RIGHTS CERTIFICATES.    All Rights Certificates surrendered for the purpose of exercise, transfer, split up, combination or exchange shall,
if surrendered to the Company or to any of its agents, be delivered to the Rights Agent for cancellation or in cancelled form, or, if surrendered to the Rights Agent, shall be cancelled by it, and no Rights Certificates shall be issued in lieu
thereof except as expressly permitted by this Agreement. The Company shall deliver to the Rights Agent for cancellation and retirement, and the Rights Agent shall so cancel and retire, any other Rights Certificate purchased or acquired by the
Company otherwise than upon the exercise thereof. The Rights Agent shall deliver all cancelled Rights Certificates to the Company, or shall, at the written request of the Company, destroy such cancelled Rights Certificates, and in such case shall
deliver a certificate of destruction thereof to the Company. 
  
 
Section 9.    RESERVATION AND AVAILABILITY OF PREFERRED STOCK. 
  
 (a) The Company covenants and agrees that it will use its commercially reasonable efforts to cause to be reserved and kept available out of and to the extent of its authorized and unissued Preferred Stock not reserved for another
purpose a number of shares of Preferred Stock that will be sufficient to permit the exercise in full of all outstanding Rights. Upon the occurrence of any events resulting in an increase in the aggregate number of shares of Preferred Stock (or other
equity securities of the Company) issuable upon exercise of all outstanding Rights above the number then reserved, the Company shall make appropriate increases in the number of shares so reserved. 

 
 10 

  
 (b)  If the Units to be issued and delivered upon the
exercise of the Rights are at any time listed on a national securities exchange or included for quotation on any transaction reporting system, the Company shall during the period from the Distribution Date to the Expiration Date to the extent
reasonably practicable cause all shares reserved for such issuance to be listed on such exchange or included for quotation on any such transaction reporting system upon official notice of issuance upon such exercise. 
  
 (c)  The Company shall to the extent reasonably practicable (i) file, as soon as practicable following the
earliest date after the first occurrence of a Section 11(a)(ii) Event in which the consideration to be delivered by the Company upon exercise of the Rights has been determined in accordance with Section 11(a)(iii), or as soon as is required by law
following the Distribution Date, as the case may be, a registration statement under the Securities Act, with respect to the securities purchasable upon exercise of the Rights on an appropriate form, (ii) cause such registration statement to become
effective as soon as practicable after such filing, and (iii) cause such registration statement to remain effective (with a prospectus at all times meeting the requirements of the Securities Act) until the earlier of (A) the date as of which the
Rights are no longer exercisable for such securities and (B) the Expiration Date. The Company will also take such action as may be appropriate under, or to ensure compliance with, the securities or “blue sky” laws of the various states in
connection with the exercisability of the Rights. Notwithstanding any provision of this Agreement to the contrary, the Rights shall not be exercisable in any jurisdiction, unless the requisite qualification of the offering made upon exercise of the
Rights in such jurisdiction shall have been obtained, or an exemption therefrom shall be available and until a registration statement has been declared effective. 
  
 (d)  The Company covenants and agrees that it will take all such action as may be necessary to ensure that all Units (and, following the
occurrence of a Triggering Event, any other securities that may be delivered upon exercise of Rights) shall, at the time of delivery of the certificates for such Units (subject to payment of the Purchase Price), be duly and validly authorized and
issued and fully paid and non-assessable. 
  
 (e)  The Company further covenants and agrees
that it will pay when due and payable any and all federal and state transfer taxes and charges which may be payable in respect of the issuance or delivery of the Rights Certificates or of any Units upon the exercise of Rights. The Company shall not,
however, be required to pay any transfer tax which may be payable in respect of any transfer or delivery of Rights Certificates to a Person other than, or the issuance or delivery of certificates or depositary receipts for Units in a name other than
that of, the registered holder of the Rights Certificate evidencing Rights surrendered for exercise or to issue or to deliver any certificates or depositary receipts for Units upon the exercise of any Rights until any such tax shall have been paid
(any such tax being payable by the holder of such Rights Certificate at the time of surrender) or until it has been established to the Company’s reasonable satisfaction that no such tax is due. 
  
 
Section 10.    PREFERRED STOCK RECORD DATE.    Each Person in whose name any certificate for Units (or, following the occurrence of a Triggering Event, other securities) is issued upon
the exercise of Rights shall for all purposes be deemed to have become the holder of record of the Units (or, following the occurrence of a Triggering Event, other securities) represented thereby on, and such certificate shall be dated, at the Close
of Business on the date 

 
 11 

 upon which the Rights Certificate evidencing such Rights was duly surrendered and payment of the Purchase Price (and any applicable transfer
taxes) was made; PROVIDED, however, that if the date of such surrender and payment is a date upon which the Preferred Stock (or, following the occurrence of a Triggering Event, other securities) transfer books of the Company are closed, such Person
shall be deemed to have become the record holder of such shares at the Close of Business on, and such certificate shall be dated, the next succeeding Business Day on which such transfer books are open; PROVIDED, further that if delivery of Units (or
such other securities) is delayed pursuant to Section 9(c), such Persons shall be deemed to have become the record holders of such Units (or such other securities) only when such Units first become deliverable. Prior to the exercise of the Rights
evidenced thereby, the holder of a Rights Certificate shall not be entitled to any rights of a stockholder of the Company with respect to securities for which the Rights shall be exercisable, including, without limitation, the right to vote, to
receive dividends or other distributions or to exercise any preemptive rights, and shall not be entitled to receive any notice of any proceedings of the Company, except as expressly provided in this Agreement. 
  
 
Section 11.    ADJUSTMENT OF PURCHASE PRICE, NUMBER OF SHARES OR NUMBER OF RIGHTS.    The Purchase Price, the number and kinds of securities covered by each Right and the number of
Rights outstanding are subject to adjustment from time to time as provided in this Section 11. 
  
 (a)  (i)  In the event the Company shall at any time after the date of this Agreement (A) declare a dividend on the Preferred Stock payable in shares of Preferred Stock, (B) subdivide the outstanding shares of
Preferred Stock, (C) combine the outstanding Preferred Stock into a smaller number of shares of Preferred Stock, or (D) issue any shares of its capital stock in a reclassification of the Preferred Stock (including any such reclassification in
connection with a consolidation or merger in which the Company is the continuing or surviving corporation), except as otherwise provided in this Section 11(a), the Purchase Price in effect at the time of the Record Date for such dividend or of the
effective date of such subdivision, combination or reclassification, and the number and kind of shares of capital stock for which the Rights shall be exercisable, shall be proportionately adjusted so that the holder of any Rights exercised after
such time shall be entitled to receive, upon payment of the Purchase Price then in effect, the aggregate number and kind of shares of capital stock which, if such Rights had been exercised immediately prior to such date and at a time when the
applicable transfer books were open, such holder would have owned upon such exercise and been entitled to receive by virtue of such dividend, subdivision, combination or reclassification; PROVIDED, however that in no event shall the consideration to
be paid upon the exercise of one Right be less than the aggregate par value of the shares of capital stock issuable upon exercise of one Right. If an event occurs which would require an adjustment under both this Section 11(a)(i) and Section
11(a)(ii), the adjustment provided for in this Section 11(a)(i) shall be in addition, and shall be made prior, to any adjustment required pursuant to Section 11(a)(ii). 
  
 (ii)  Subject to Section 24, if: 
  
 (A)  any Person shall become an Acquiring Person, unless the event causing the Person to become an Acquiring Person is a transaction to which the provisions of Section 13(a) apply;

 
 12 

  
 (B)  any Acquiring Person or any Associate or
Affiliate of any Acquiring Person, at any time after the date of this Agreement, directly or indirectly, shall (1) merge into the Company or otherwise combine with the Company and the Company shall be the continuing or surviving corporation of such
merger or combination and shares of Common Stock of the Company shall remain outstanding and unchanged, (2) in one transaction or a series of transactions, transfer any assets to the Company or any of its Subsidiaries in exchange (in whole or in
part) for shares of Common Stock of the Company, for other equity securities of the Company or any of its Subsidiaries, or for securities exercisable for or convertible into shares of equity securities of the Company or any of its Subsidiaries
(whether shares of Common Stock of the Company or otherwise) or otherwise obtain from the Company or any of its Subsidiaries, with or without consideration, any additional shares of such equity securities or securities exercisable for or convertible
into such equity securities (other than pursuant to a pro rata distribution to all holders of shares of Common Stock of the Company), (3) sell, purchase, lease, exchange, mortgage, pledge, transfer or otherwise acquire or dispose of, in one
transaction or a series of transactions, to, from or with the Company or any of its Subsidiaries or any employee benefit plan maintained by the Company or any of its Subsidiaries or any trustee or fiduciary with respect to such plan acting in such
capacity, assets (including securities) on terms and conditions less favorable to the Company or such Subsidiary or plan than those that could have been obtained in arm’s-length negotiations with an unaffiliated third party, other than pursuant
to a transaction set forth in Section 13(a), (4) sell, purchase, lease, exchange, mortgage, pledge, transfer or otherwise acquire or dispose of, in one transaction or a series of transactions, to, from or with the Company or any of its Subsidiaries
or any employee benefit plan maintained by the Company or any of its Subsidiaries or any trustee or fiduciary with respect to such plan acting in such capacity (other than transactions, if any, consistent with those engaged in, as of the date
hereof, by the Company and such Acquiring Person or such Associate or Affiliate), assets (including securities or intangible assets) having an aggregate fair market value of more than $5,000,000, other than pursuant to a transaction set forth in
Section 13(a), (5) receive, or any designee, agent or representative of such Acquiring Person or any Affiliate or Associate of such Acquiring Person shall receive, any compensation from the Company or any of its Subsidiaries other than compensation
for full-time employment as a regular employee at rates in accordance with the Company’s (or its Subsidiaries’) past practices, or (6) receive the benefit, directly or indirectly (except proportionately as a holder of shares of Common
Stock of the Company or as required by law or governmental regulation), of any loans, advances, guarantees, pledges or other financial assistance or any tax credits or other tax advantages provided by the Company or any of its Subsidiaries or any
employee benefit plan maintained by the Company or any of its Subsidiaries or any trustee or fiduciary with respect to such plan acting in such capacity; or 
  
 (C)  during such time as there is an Acquiring Person, there shall be any reclassification of securities (including any reverse stock split), or
recapitalization of the Company, or any merger or consolidation of the Company with any of its Subsidiaries or any other transaction or series of transactions involving the Company or any of its Subsidiaries, other than a transaction or transactions
to which the provisions of Section 13(a) apply (whether or not with or into or otherwise involving an Acquiring Person), which has the effect, directly or indirectly, of increasing by more than one percent the proportionate share of the outstanding
shares of any class of equity securities of the Company or any of its Subsidiaries that is directly or indirectly beneficially owned by any Acquiring Person or any Person or any Associate or Affiliate of any Acquiring Person; 

 
 13 

  
 then promptly following the occurrence of an event described in
Section 11(a)(ii)(A), (B) or (C) (a “SECTION 11(a)(ii) EVENT”), proper provision shall be made so that each holder of a Right, except as otherwise provided in Section 7(e), shall thereafter have the right to receive for each Right, upon
exercise thereof in accordance with the terms of this Agreement and payment of the then-current Purchase Price, in lieu of the number of Units for which a Right was exercisable immediately prior to the first occurrence of a Section 11(a)(ii) Event,
such number of Units as shall equal the result obtained by multiplying the then-current Purchase Price by the then number of Units for which a Right was exercisable (or would have been exercisable if the Distribution Date had occurred) immediately
prior to the first occurrence of a Triggering Event, and dividing that product by 50% of the Current Per Share Market Price for shares of Common Stock on the date of occurrence of the Triggering Event (such number of Units being hereinafter referred
to as the “ADJUSTMENT SHARES”). Upon the occurrence of a Section 13 Event, any Rights that shall not have been previously exercised pursuant to this Section 11(a)(ii) shall thereafter be exercisable only pursuant to Section 13 and not
pursuant to this Section 11(a)(ii). 
  
 (iii)  In the event that the number of shares of
Preferred Stock which are authorized by the Company’s Amended and Restated Certificate of Incorporation, as amended, but not outstanding or reserved for issuance for purposes other than upon exercise of the Rights are not sufficient to permit
the exercise in full of the Rights, or if any necessary regulatory approval for such issuance has not been obtained by the Company, the Company shall, in lieu of issuing Units in accordance with Section 11(a)(ii) hereof: (A) determine the excess of
(1) the value of the Units issuable upon the exercise of a Right (the “CURRENT VALUE”) over (2) the Purchase Price (such excess being referred to as the “SPREAD”) and (B) with respect to each Right, make adequate provision to
substitute for such Units, upon exercise of the Rights, (1) cash, (2) a reduction in the Purchase Price, (3) other equity securities of the Company (including, without limitation, Common Stock of the Company or shares or units of shares of any
series of preferred stock which the Board of Directors of the Company shall have conclusively deemed to have the same value as the Units (such shares or units of preferred stock are herein called “PREFERRED STOCK EQUIVALENTS”)), except to
the extent that the Company has not obtained any necessary regulatory approval for such issuance, (4) debt securities of the Company, except to the extent that the Company has not obtained any necessary regulatory approval for such issuance, (5)
other assets, or (6) any combination of the foregoing, having an aggregate value equal to the Current Value, as determined by the Board of Directors of the Company based upon the advice of a nationally recognized investment banking firm selected by
the Board of Directors of the Company (which determination shall be described in a statement filed with the Rights Agent and shall be conclusive and binding on the Rights Agent, the holders of the Rights and all other Persons); PROVIDED, HOWEVER, if
the Company shall not have made adequate provision to deliver value pursuant to clause (B) above within thirty calendar days following the later of (x) occurrence of a Section 11(a)(ii) Event, and (y) the date on which the Company’s right of
redemption pursuant to Section 23(a) expires (the later of (x) and (y) being referred to herein as the “SECTION 11(A)(III) TRIGGER DATE”), then the Company shall be obligated to deliver, upon the surrender for exercise of a Right and
without requiring payment of the Purchase Price, Units (to the extent available), except to the extent that the Company has not obtained any necessary regulatory approval for such issuance, and then, if necessary, cash, having an aggregate value
equal to the Spread. 

 
 14 

  
 (b)  If the Company shall fix a Record Date for the
issuance of rights, options or warrants to all holders of Preferred Stock entitling them (for a period expiring within forty-five calendar days after such Record Date) to subscribe for or purchase Preferred Stock (or shares having the same rights,
privileges and preferences as the Preferred Stock (the “EQUIVALENT PREFERRED STOCK”)) or securities convertible into Preferred Stock or Equivalent Preferred Stock at a price per Unit of Preferred Stock or Equivalent Preferred Share (or
having a conversion price per Unit, if a security convertible into Units or Equivalent Preferred Stock) less than the then Current Per Share Market Price (as determined pursuant to Section 11(d)) of a Unit of Preferred Stock on such Record Date, the
Purchase Price to be in effect after such Record Date shall be determined by multiplying the Purchase Price in effect immediately prior to such Record Date by a fraction, the numerator of which shall be the sum of the number of Units outstanding on
such Record Date plus the number of Units which the aggregate offering price of the total number of Units and/or Equivalent Preferred Stock so to be offered (and/or the aggregate initial conversion price of the convertible securities so to be
offered) would purchase at such Current Per Share Market Price and the denominator of which shall be the sum of the number of Units outstanding on such Record Date PLUS the number of additional Units and/or Equivalent Preferred Stock to be offered
for subscription or purchase (or into which the convertible securities so to be offered are initially convertible). If such subscription price may be paid in a consideration part or all of which shall be in a form other than cash, the value of such
consideration shall be as determined in good faith by the Board of Directors of the Company, whose determination shall be described in a statement filed with the Rights Agent and shall be conclusive and binding on the Rights Agent and the holders of
the Rights. Units owned by or held for the account of the Company shall not be deemed outstanding for the purpose of any such computation. Such adjustment shall be made successively whenever such a Record Date is fixed; and if such rights, options
or warrants are not so issued, the Purchase Price shall be adjusted to be the Purchase Price which would then be in effect if such Record Date had not been fixed. 
  
 (c)  If the Company shall fix a Record Date for a distribution to all holders of Units (including any such distribution made in connection with a
consolidation or merger in which the Company is the continuing or surviving corporation) of evidences of indebtedness, cash (other than a regular quarterly cash dividend), assets (other than a dividend payable in Units but including any dividend
payable in equity securities other than Preferred Stock) or subscription rights or warrants (excluding those referred to in Section 11(d)), the Purchase Price to be in effect after such Record Date shall be determined by multiplying the Purchase
Price in effect immediately prior to such Record Date by a fraction, the numerator of which shall be the then Current Per Share Market Price (as determined pursuant to Section 11(d)) of the Preferred Stock on such Record Date, less the fair market
value (as determined in good faith by the Board of Directors of the Company, whose determination shall be described in a statement filed with the Rights Agent and shall be conclusive and binding on the Rights Agent and the holders of the Rights) of
the cash, assets or evidences of indebtedness to be distributed or of such subscription rights or warrants distributable in respect of a share of Preferred Stock, and the denominator of which shall be such Current Per Share Market Price of a share
of Preferred Stock. Such adjustments shall be made successively whenever such a Record Date is fixed; and in the event that such distribution is not so made, the Purchase Price shall again be adjusted to be the Purchase Price which would then be in
effect if such Record Date had not been fixed. 

 
 15 

  
 (d)  (i)  For the purpose of any computation
hereunder, the “CURRENT PER SHARE MARKET PRICE” of any security on any date shall be deemed to be the average of the daily closing prices per share of such security for the thirty (30) consecutive Trading Days (as defined below) ending on
and including the Trading Day immediately prior to such date; PROVIDED, HOWEVER, that in the event that the Current Per Share Market Price of the security is determined during a period following the announcement by the issuer of such security of (A)
a dividend or distribution on such security payable in shares of such security or securities convertible into such shares, or (B) any subdivision, combination or reclassification of such security and prior to the expiration of thirty Trading Days
after and not including the ex-dividend date for such dividend or distribution, or the Record Date for such subdivision, combination or reclassification, then, and in each such case, the Current Per Share Market Price shall be appropriately adjusted
to reflect the current market price per share equivalent of such security. The closing price for each day shall be the last sale price, regular way, or, in case no such sale takes place on such day, the average of the closing bid and asked prices,
regular way, in either case as reported in the principal consolidated transaction reporting system with respect to securities listed or admitted to trading on the Nasdaq National Market System (“NASDAQ”) or, if the security is not listed
or admitted to trading on NASDAQ, as reported in the principal consolidated transaction reporting system with respect to securities listed on the principal national securities exchange on which the security is listed or admitted to trading or, if
the security is not listed or admitted to trading on any national securities exchange, the last quoted price or, if not so quoted, the average of the high bid and low asked prices in the over-the-counter market, as reported by NASDAQ or such other
system then in use, or, if on any such date the security is not quoted by any such organization, the average of the closing bid and asked prices as furnished by a professional market maker making a market in the security selected by the Board of
Directors of the Company. If on any such date no market maker is making a market in the security, the Current Per Share Market Price of such security on such date shall mean the fair value per share or other trading unit as determined in good faith
by the Board of Directors of the Company as provided for above shall be used (which determination shall be described in a statement filed with the Rights Agent and shall be conclusive and binding on the Rights Agent, the holders of the Rights and
all other Persons). The term “TRADING DAY” shall mean a day on which the principal national securities exchange on which the security is listed or admitted to trading is open for the transaction of business or, if the security is not
listed or admitted to trading on any national securities exchange, a Business Day. 
  
 (ii)  For the purpose of any computation hereunder, the Current Per Share Market Price of the Preferred Stock shall be determined in accordance with the method set forth in Section 11(d)(i). If the Current Per Share Market
Price of the Preferred Stock cannot be determined in the manner provided above or if the Preferred Stock is not publicly held or listed or traded in a manner described in Section 11(d)(i), the Current Per Share Market Price of the Preferred Stock
shall be conclusively deemed to be an amount equal to the product of $1,000 (as such amount may be appropriately adjusted for such events as stock splits, stock dividends and recapitalizations with respect to shares of Common Stock of the Company
occurring after the date of this Agreement) multiplied by the Current Per Share Market Price of Common Stock of the Company. If no shares of the Common Stock of the Company or the Preferred Stock are publicly held or so listed or traded,
“CURRENT PER SHARE MARKET PRICE” of the Preferred Stock shall mean the fair value per share as determined in good faith by the Board of Directors of the Company, whose determination shall be described in a statement filed with the

 
 16 

 Rights Agent and shall be conclusive and binding on the Rights Agent and the holders of the Rights. For all purposes of
this Agreement, the Current Per Share Market Price of a Unit of Preferred Stock shall be equal to the Current Per Share Market Price of one share of Preferred Stock divided by 1,000. 
  
 (e)  No adjustment in the Purchase Price shall be required unless such adjustment would require an increase or decrease of at least one percent in
the Purchase Price; PROVIDED, HOWEVER, that any adjustments which by reason of this Section 11(e) are not required to be made shall be carried forward and taken into account in any subsequent adjustment. All calculations under this Section 11 shall
be made to the nearest cent or to the nearest one-millionth of a share of Preferred Stock or one one-hundredth of any other share or security as the case may be. Notwithstanding the first sentence of this Section 11(e), any adjustment required by
this Section 11 shall be made no later than the earlier of (i) three years from the date of the transaction which requires such adjustment or (ii) the Expiration Date. 
  
 (f)  If as a result of an adjustment made pursuant to Section 11(a)(ii), the holder of any Rights thereafter exercised shall become entitled to
receive any shares of capital stock of the Company other than Units, thereafter the number of such other shares so receivable upon exercise of any Rights and the Purchase Price thereof shall be subject to adjustment from time to time in a manner and
on terms as nearly equivalent as practicable to the provisions with respect to the Preferred Stock contained in Sections 11(a), (b), (c), (d), (e), (g), (h), (i), (j), (k), (l) and (m), and the provisions of Sections 7, 9, 10, 13 and 14 with respect
to the Preferred Stock shall apply on like terms to any such other shares. 
  
 (g)  All
Rights originally issued by the Company subsequent to any adjustment made to the Purchase Price shall evidence the right to purchase, at the adjusted Purchase Price, the number of Units purchasable from time to time upon exercise of the Rights, all
subject to further adjustment as provided in this Agreement. 
  
 (h)  Unless the Company
shall have exercised its election under Section 11(i), upon each adjustment of the Purchase Price as a result of the calculations made in Sections 11(b) and (c), each Right outstanding immediately prior to the making of such adjustment shall
thereafter evidence the right to purchase, at the adjusted Purchase Price, that number of Units (calculated to the nearest one-millionth of a share of Preferred Stock) obtained by dividing (i) the product obtained by multiplying (x) the number of
Units covered by a Right immediately prior to this adjustment by (y) the Purchase Price in effect immediately prior to such adjustment of the Purchase Price, by (ii) the Purchase Price in effect immediately after such adjustment of the Purchase
Price. 
  
 (i)  The Company may elect on or after the date of any adjustment of the
Purchase Price to adjust the number of Rights, in substitution for any adjustment in the number of Units purchasable upon the exercise of a Right. Each of the Rights outstanding after such adjustment of the number of Rights shall be exercisable for
the number of Units for which a Right was exercisable immediately prior to such adjustment. Each Right held of record prior to such adjustment of the number of Rights shall become that number of Rights (calculated to the nearest one-thousandth)
obtained by dividing the Purchase Price in effect immediately prior to adjustment of the Purchase Price by the Purchase Price in effect immediately after adjustment of 

 
 17 

 the Purchase Price. The Company shall make a public announcement of its election to adjust the number of Rights,
indicating the Record Date for the adjustment, and, if known at the time, the amount of the adjustment to be made. This Record Date may be the date on which the Purchase Price is adjusted or any day thereafter, but, if the Rights Certificates have
been issued, shall be at least ten days later than the date of the public announcement. If Rights Certificates have been issued, upon each adjustment of the number of Rights pursuant to this Section 11(i), the Company shall, as promptly as
practicable, cause to be distributed to holders of record of Rights Certificates on such Record Date Rights Certificates evidencing, subject to Section 14, the additional Rights to which such holders shall be entitled as a result of such adjustment,
or, at the option of the Company, shall cause to be distributed to such holders of record in substitution and replacement for the Rights Certificates held by such holders prior to the date of adjustment, and upon surrender thereof, if required by
the Company, new Rights Certificates evidencing all the Rights to which such holders shall be entitled after such adjustment. Rights Certificates to be so distributed shall be issued, executed and countersigned in the manner provided for herein and
shall be registered in the names of the holders of record of Rights Certificates on the Record Date specified in the public announcement. 
  
 (j)  Irrespective of any adjustment or change in the Purchase Price or the number of Units issuable upon the exercise of the Rights, the Rights Certificates theretofore and thereafter issued
may continue to express the Purchase Price per Unit and the number of Units which were expressed in the initial Rights Certificates issued hereunder. 
  
 (k)  Before taking any action that would cause an adjustment reducing the Purchase Price below the then par value of the number of Units issuable
upon exercise of the Rights, the Company shall take any corporate action which may, in the opinion of its counsel, be necessary in order that the Company may validly and legally issue fully paid and nonassessable number of Units at such adjusted
Purchase Price. 
  
 (l)  In any case in which this Section 11 shall require that an
adjustment in the Purchase Price be made effective as of a Record Date for a specified event, the Company may elect to defer until the occurrence of such event the issuing to the holder of any Rights exercised after such Record Date of that number
of Units and other capital stock or securities of the Company, if any, issuable upon such exercise over and above the Units and other capital stock or securities of the Company, if any, issuable upon such exercise on the basis of the Purchase Price
in effect prior to such adjustment; PROVIDED, HOWEVER, that the Company shall deliver to such holder a due bill or other appropriate instrument evidencing such holder’s right to receive such additional shares (fractional or otherwise) upon the
occurrence of the event requiring such adjustment. 
  
 (m)  Anything in this Section 11 to
the contrary notwithstanding, the Company shall be entitled to make such reductions in the Purchase Price, in addition to those adjustments expressly required by this Section 11, as and to the extent that it in its sole discretion shall determine to
be advisable in order that any (i) consolidation or subdivision of the Preferred Stock, (ii) issuance wholly for cash of any Unit of Preferred Stock at less than the Current Per Share Market Price, (iii) issuance wholly for cash of Preferred Stock
or securities which by their terms are convertible into or exchangeable for Preferred Stock, (iv) dividends on Preferred Stock payable in Preferred Stock, or (v) issuance of rights, options or warrants referred to in this 

 
 18 

 Section 11, hereafter made by the Company to holders of Units of its Preferred Stock shall not be taxable to such
stockholders. 
  
 (n)  The Company shall not, at any time after the Distribution Date, (i)
consolidate with any other Person (other than a Subsidiary of the Company in a transaction which complies with Section 11(o)), (ii) merge with or into any other Person (other than a Subsidiary of the Company in a transaction which complies with
Section 11(o)), or (iii) sell or transfer (or permit any Subsidiary to sell or transfer), in one transaction, or a series of transactions, assets or earning power aggregating more than 50% of the assets or earning power of the Company and its
Subsidiaries (taken as a whole) to any other Person or Persons (other than the Company and/or any of its Subsidiaries in one or more transactions each of which complies with Section 11(o)), if (x) at the time of or immediately after such
consolidation, merger or sale there are any rights, warrants or other instruments or securities outstanding or agreements in effect which would substantially diminish or otherwise eliminate the benefits intended to be afforded by the Rights or (y)
prior to, simultaneously with or immediately after such consolidation, merger or sale, the Person which constitutes, or would constitute, the Principal Party (as defined in Section 13(b)) shall have distributed or otherwise transferred to its
stockholders or other Persons holding an equity interest in such Person, Rights previously owned by such Person or any of its Affiliates and Associates; PROVIDED, HOWEVER, this Section 11(n) shall not affect the ability of any Subsidiary of the
Company to consolidate with, merge with or into, or sell or transfer assets or earning power to, any other Subsidiary of the Company. 
  
 (o)  After the Distribution Date, the Company shall not, except as permitted by Section 23 or Section 26, take (or permit any of its Subsidiaries to take) any action if at the time such
action is taken it is reasonably foreseeable that such action will diminish substantially or otherwise eliminate the benefits intended to be afforded by the Rights. 
  
 (p)  If, at any time after the date of this Agreement and prior to the Distribution Date, the Company shall (i) declare or pay any dividend on
outstanding shares of Common Stock of the Company payable in shares of Common Stock of the Company or (ii) effect a subdivision, combination or consolidation of the Common Stock of the Company (by reclassification or otherwise than by payment of
dividends in shares of Common Stock of the Company) into a greater or lesser number of shares of Common Stock of the Company, then in any such case the number of Units purchasable after such event upon proper exercise of each Right shall be
determined by multiplying the number of Units so purchasable immediately prior to such event by a fraction, the numerator of which shall be the number of shares of Common Stock of the Company outstanding immediately before such event and the
denominator of which shall be the number of shares of Common Stock of the Company outstanding immediately after such event. The adjustments provided for in this Section 11(p) shall be made successively whenever such a dividend is declared or paid or
such a subdivision, combination or consolidation is effected. 
  
 
Section 12.    CERTIFICATE OF ADJUSTED PURCHASE PRICE OR NUMBER OF SHARES.    Whenever an adjustment is made as provided in Sections 11 and 13, the Company shall promptly (a) prepare a
certificate setting forth such adjustment, and a brief statement of the 

 
 19 

 facts accounting for such adjustment, (b) file with the Rights Agent and with each transfer agent for the shares of Common Stock of the Company
or Units a copy of such certificate and (c) mail a brief summary thereof to each holder of a Rights Certificate in accordance with Section 25 hereof. Notwithstanding the foregoing sentence, the failure by the Company to make such certification or
give such notice shall not affect the validity of or the force or effect of the requirement for such adjustment. The Rights Agent shall be fully protected in relying on any such certificate and on any adjustment contained therein and shall not be
deemed to have knowledge of such adjustment unless and until it shall have received such certificate. 
  
 
Section 13.    CONSOLIDATION, MERGER OR SALE OR TRANSFER OF ASSETS OR EARNING POWER. 
  
 (a)  Except as provided in Section 13(b), in the event that, following a Share Acquisition Date, directly or indirectly, (x) the Company shall consolidate with, or merge with and into, any
other Person (other than a Subsidiary of the Company in a transaction which complies with Section 11(o)), and the Company shall not be the continuing or surviving corporation of such consolidation or merger, (y) any Person (other than a Subsidiary
of the Company in a transaction which complies with Section 11(o)) shall consolidate with the Company, or merge with and into the Company and the Company shall be the continuing or surviving corporation of such consolidation or merger and, in
connection with such consolidation or merger, all or part of the shares of Common Stock of the Company shall be changed into or exchanged for stock or other securities of any other Person or cash or any other property, or (z) the Company shall sell
or otherwise transfer (or one or more of its Subsidiaries shall sell or otherwise transfer) to any Person or Persons (other than a Subsidiary of the Company in a transaction which complies with Section 11(o)), in one or more transactions, directly
or indirectly, assets or earning power aggregating 50% or more of the assets or earning power of the Company and its Subsidiaries (taken as a whole), (any such event being a “SECTION 13 EVENT”), then, and in each such case, proper
provision shall be made so that: (i) each holder of a Right, except as provided in Section 7(e), shall thereafter have the right to receive, upon the exercise thereof at the then current Purchase Price, such number of validly authorized and issued,
fully paid and non-assessable shares of Common Stock of the Principal Party, which shares shall not be subject to any liens, encumbrances, rights of first refusal, transfer restrictions or other adverse claims, as shall be equal to the result
obtained by (1) multiplying the then current Purchase Price by the number of Units for which a Right is exercisable immediately prior to the first occurrence of a Section 13 Event (or, if a Section 11(a)(ii) Event has occurred prior to the first
occurrence of a Section 13 Event, multiplying the number of such Units for which a Right would be exercisable hereunder but for the occurrence of such Section 11(a)(ii) Event by the Purchase Price which would be in effect hereunder but for such
first occurrence) and (2) dividing that product (which, following the direct occurrence of a Section 13 Event, shall be the “PURCHASE PRICE” for all purposes of this Agreement) by 50% of the Current Per Share Market Price of the shares of
Common Stock of such Principal Party on the date of consummation of such Section 13 Event; (ii) such Principal Party shall thereafter be liable for, and shall assume, by virtue of such Section 13 Event, all the obligations and duties of the Company
pursuant to this Agreement; (iii) the term “COMPANY” shall, for all purposes of this Agreement, thereafter be deemed to refer to such Principal Party, it being specifically intended that the provisions of Section 11 shall apply only to
such Principal Party following the first occurrence of a Section 13 Event; (iv) such Principal Party shall take such steps (including, but 

 
 20 

 not limited to, the reservation of a sufficient number of shares of its Common Stock) in connection with the consummation
of any such transaction as may be necessary to ensure that the provisions of this Agreement shall thereafter be applicable to its shares of Common Stock thereafter deliverable upon the exercise of the Rights; and (v) the provisions of Section
11(a)(ii) shall be of no further effect following the first occurrence of any Section 13 Event. 
  
 (b)  “PRINCIPAL PARTY” shall mean: 
  
 (i)  in the case
of any transaction described in clause (x) or (y) of the first sentence of Section 13(a), (A) the Person that is the issuer of any securities into which shares of Common Stock of the Company are converted in such merger or consolidation, or, if
there is more than one such issuer, the issuer whose outstanding shares of Common Stock have the greatest aggregate Current Per Share Market Price and (B) if no securities are so issued, the Person that is the other party to such merger or
consolidation, or, if there is more than one such Person, the Person whose outstanding shares of Common Stock have the greatest aggregate Current Per Share Market Price; and 
  
 (ii)  in the case of any transaction described in clause (z) of the first sentence of Section 13(a), the Person that is the party receiving the
largest portion of the assets or earning power transferred pursuant to such transaction or transactions, or, if each Person that is a party to such transaction or transactions receives the same portion of the assets or earning power transferred
pursuant to such transaction or transactions or if the Person receiving the largest portion of the assets or earning power cannot be determined, whichever Person whose outstanding shares of Common Stock have the greatest aggregate Current Per Share
Market Price; PROVIDED, HOWEVER, that in any such case, (1) if the Common Stock of such Person is not at such time and has not been continuously over the preceding twelve-month period registered under Section 12 of the Exchange Act (the
“REGISTERED COMMON STOCK”), or such Person is not a corporation, and such Person is a direct or indirect Subsidiary of another Person that has Registered Common Stock outstanding, “Principal Party” shall refer to such other
Person; (2) if the Common Stock of such Person is not Registered Common Stock or such Person is not a corporation, and such Person is a direct or indirect Subsidiary of another Person but is not a direct or indirect Subsidiary of another Person
which has Registered Common Stock outstanding, “Principal Party” shall refer to the ultimate parent entity of such first-mentioned Person; (3) if the Common Stock of such Person is not Registered Common Stock or such Person is not a
corporation, and such Person is directly or indirectly controlled by more than one Person, and one or more of such other Persons has Registered Common Stock outstanding, “Principal Party” shall refer to whichever of such other Persons is
the issuer of the Registered Common Stock having the highest aggregate Current Per Share Market Price; and (4) if the Common Stock of such Person is not Registered Common Stock or such Person is not a corporation, and such Person is directly or
indirectly controlled by more than one Person, and none of such other Persons has Registered Common Stock outstanding, “Principal Party” shall refer to whichever ultimate parent entity is the corporation having the greatest
stockholders’ equity or, if no such ultimate parent entity is a corporation, shall refer to whichever ultimate parent entity is the entity having the greatest net assets. 
  
 (c)  The Company shall not consummate any such consolidation, merger, sale or transfer unless the Principal Party shall have a sufficient number
of authorized shares of its 

 
 21 

 Common Stock which have not been issued or reserved for issuance to permit the exercise in full of the Rights in
accordance with this Section 13, and unless prior thereto the Company and such Principal Party shall have executed and delivered to the Rights Agent a supplemental agreement providing for the terms set forth in paragraphs (a) and (b) of this Section
13 and further providing that the Principal Party will: 
  
 (i)  (A)  file on an
appropriate form, as soon as practicable following the execution of such agreement, a registration statement under the Securities Act with respect to the shares of Common Stock of such Principal Party that may be acquired upon exercise of the
Rights, (B) cause such registration statement to remain effective (and to include a prospectus complying with the requirements of the Securities Act) until the Expiration Date, and (C) as soon as practicable following the execution of such agreement
take such action as may be required to ensure that any acquisition of such shares of Common Stock of such Principal Party upon the exercise of the Rights complies with any applicable state securities or “blue sky” laws; and 

 
 (ii)  deliver to holders of the Rights historical financial statements for the Principal Party and
each of its Affiliates which comply in all respects with the requirements for registration on Form 10 (or any successor form) under the Exchange Act. 
  
 (d)  In case the Principal Party which is to be a party to a transaction referred to in this Section 13 has a provision in any of its authorized
securities or in its Amended and Restated Certificate of Incorporation, as amended, bylaws or other instrument governing its corporate affairs, which provision would have the effect of (i) causing such Principal Party to issue, in connection with,
or as a consequence of, the consummation of a transaction referred to in this Section 13, shares of Common Stock of such Principal Party at less than the Current Per Share Market Price or securities exercisable for, or convertible into, shares of
Common Stock of such Principal Party at less than the Current Per Share Market Price (other than to holders of Rights pursuant to this Section 13) or (ii) providing for any special payment, tax or similar provisions in connection with the issuance
of the shares of Common Stock of such Principal Party pursuant to the provisions of this Section 13, then, in such event, the Company shall not consummate any such transaction unless prior thereto the Company and such Principal Party shall have
executed and delivered to the Rights Agent a supplemental agreement providing that the provision in question of such Principal Party shall have been cancelled, waived or amended, or that the authorized securities shall be redeemed, so that the
applicable provision will have no effect in connection with, or as a consequence of, the consummation of the proposed transaction. 
  
 (e)  The provisions of this Section 13 shall similarly apply to successive mergers or consolidations or sales or other transfers. In the event that a Section 13 Event shall occur at any time
after the occurrence of a Section 11(a)(ii) Event, except for Rights that have become null and void pursuant to Section 11(a)(ii), Rights that shall not have been previously exercised will cease to be exercisable in the manner provided in Section
11(a)(ii) and will thereafter be exercisable in the manner provided in section 13(a). 
  
 
Section 14.    FRACTIONAL RIGHTS AND FRACTIONAL SHARES. 
  
 (a)  The Company shall not be required to issue fractions of Rights or to distribute Rights Certificates which evidence fractional Rights. In lieu of such fractional Rights, 

 
 22 

 there shall be paid to the registered holders of the Rights Certificates with regard to which such fractional Rights
would otherwise be issuable, an amount in cash equal to the same fraction of the Current Per Share Market Price of a whole Right. For the purposes of this Section 14(a), the Current Per Share Market Price of a whole Right shall be the closing price
of the Rights for the Trading Day immediately prior to the date on which such fractional Rights would have been otherwise issuable. The closing price for any day shall be the last sale price, regular way, or, in case no such sale takes place on such
day, the average of the closing bid and asked prices, regular way, in either case as reported in the principal consolidated transaction reporting system with respect to securities listed or admitted to trading on NASDAQ or, if the Rights are not
listed or admitted to trading on NASDAQ, as reported in the principal consolidated transaction reporting system with respect to securities listed on the principal national securities exchange on which the Rights are listed or admitted to trading or,
if the Rights are not listed or admitted to trading on any national securities exchange, the last quoted price or, if not so quoted, the average of the high bid and low asked prices in the over-the-counter market, as reported by NASDAQ or such other
system then in use or, if on any such date the Rights are not quoted by any such organization, the average of the closing bid and asked prices as furnished by a professional market maker making a market in the Rights selected by the Board of
Directors of the Company. If on any such date no such market maker is making a market in the Rights, the fair value of the Rights on such date as determined in good faith by the Board of Directors of the Company shall be conclusively used.

  
 (b)  The Company shall not be required to issue fractions of Preferred Stock (other
than fractions which are integral multiples of one one-thousandth of a share of Preferred Stock) upon exercise of the Rights or to distribute certificates which evidence fractional Preferred Stock (other than fractions which are integral multiples
of one one-thousandth of a share of Preferred Stock). Fractions of Preferred Stock in integral multiples of one one-thousandth of a share of Preferred Stock may, at the election of the Company, be evidenced by depositary receipts, pursuant to an
appropriate agreement between the Company and a depositary selected by it; PROVIDED, HOWEVER, that such agreement shall provide that the holders of such depositary receipts shall have all the rights, privileges and preferences to which they are
entitled as Beneficial Owners of the Preferred Stock represented by such depositary receipts. In lieu of fractional shares of Preferred Stock that are not integral multiples of one one-thousandth of a share of Preferred Stock, the Company shall pay
to the registered holders of Rights Certificates at the time such Rights are exercised as herein provided an amount in cash equal to the same fraction of the Current Per Share Market Price of one share of Preferred Stock. 
  
 (c)  The holder of a Right by the acceptance of the Right expressly waives such holder’s right to receive
any fractional Rights or any fractional shares upon exercise of a Right (except as provided above). 
  
 
Section 15.    RIGHTS OF ACTION.    All rights of action in respect of this Agreement, excepting the rights of action given to the Rights Agent under Section 18, are vested in the
respective registered holders of the Rights Certificates (and, prior to the Distribution Date, the registered holders of certificates representing shares of Common Stock of the Company); and any registered holder of any Rights Certificate (or, prior
to the Distribution Date, a certificate 

 
 23 

 representing shares of Common Stock of the Company), without the consent of the Rights Agent or of the holder of any other Rights Certificate
(or, prior to the Distribution Date, of a certificate representing shares of Common Stock of the Company), may, in such holder’s own behalf and for such holder’s own benefit, enforce, and may institute and maintain any suit, action or
proceeding against the Company to enforce, or otherwise act in respect of, such holder’s right to exercise the Rights evidenced by such Rights Certificate or, prior to the Distribution Date, in the manner provided in such Rights Certificate and
in this Agreement. Without limiting the foregoing or any remedies available to the holders of Rights, it is specifically acknowledged that the holders of Rights would not have an adequate remedy at law for any breach of this Agreement and will be
entitled to specific performance of the obligations hereunder, and injunctive relief against actual or threatened violations of the obligations of any Person subject to this Agreement. 
  
 
Section 16.    AGREEMENT OF RIGHTS HOLDERS.    Every holder of a Right, by accepting the same, consents and agrees with the Company and the Rights Agent and with every other holder of a
Right that: 
  
 (a)  prior to the Distribution Date, the Rights will be transferable only
in connection with the transfer of shares of Common Stock of the Company; 
  
 (b)  after
the Distribution Date, the Rights Certificates are transferable only on the registry books of the Rights Agent if surrendered at the office of the Rights Agent designated for such purpose, duly endorsed or accompanied by a proper instrument of
transfer; 
  
 (c)  subject to Sections 6(a) and 7(f), the Company and the Rights Agent may
deem and treat the Person in whose name the Rights Certificate (or, prior to the Distribution Date, the associated Common Stock certificate) is registered as the absolute owner thereof and of the Rights evidenced thereby (notwithstanding any
notations of ownership or writing on the Rights Certificates or the associated Common Stock certificate made by anyone other than the Company or the Rights Agent) for all purposes whatsoever, and neither the Company nor the Rights Agent shall be
affected by any notice to the contrary; and 
  
 (d)  notwithstanding anything in this
Agreement to the contrary, neither the Company nor the Rights Agent shall have any liability to any holder of a Right or other Person as a result of its inability to perform any of its obligations under this Agreement by reason of any preliminary or
permanent injunction or other order, decree or ruling issued by a court of competent jurisdiction or by a governmental, regulatory or administrative agency or commission, or any statute, rule, regulation or executive order promulgated or enacted by
any governmental authority, prohibiting or otherwise restraining performance of such obligation; PROVIDED, however, the Company shall use commercially reasonably efforts to have any such order, decree or ruling lifted or otherwise overturned as soon
as practicable. 
  
 
Section 17.    RIGHTS CERTIFICATE HOLDER NOT DEEMED A STOCKHOLDER.    No holder, as such, of any Rights Certificate shall be entitled to vote, receive dividends or be deemed for any
purpose the holder of the Units or any other securities of the Company which may at any time be issuable upon the exercise of the Rights represented thereby, nor shall anything contained in this Agreement or in any Rights Certificate be construed to
confer upon the holder of any Rights Certificate, as such, any of the rights of a stockholder of the Company or any right to vote for the election of directors or upon any matter submitted to stockholders at 

 
 24 

 any meeting thereof, or to give or withhold consent to any corporate action, or to receive notice of meetings or other actions affecting
stockholders (except as provided in Section 25), or to receive dividends or subscription rights, or otherwise, until the Right or Rights evidenced by such Rights Certificate shall have been exercised in accordance with this Agreement. 

 
 
Section 18.    CONCERNING THE RIGHTS AGENT.    The Company agrees to pay to the Rights Agent reasonable compensation for all services rendered by it under this Agreement and, from time
to time, on demand of the Rights Agent, its reasonable expenses and counsel fees and other disbursements incurred in the administration and execution of this Agreement and the exercise and performance of its duties hereunder. The Company also agrees
to indemnify the Rights Agent for, and to hold it harmless against, any loss, liability, or expense, incurred without negligence or willful misconduct on the part of the Rights Agent, for any action taken, suffered or omitted by the Rights Agent in
connection with the execution, acceptance and administration of this Agreement and the exercise and performance of its duties, including the costs and expenses of defending against and appealing any claim of liability in the premises. This indemnity
shall survive the termination of this Agreement and the expiration of the Rights. The costs and expenses incurred in enforcing this right of indemnification shall be paid by the Company. 
  
 The Rights Agent may conclusively rely upon and shall be protected and shall incur no liability for, or in respect of any action taken, suffered or omitted by it in
connection with, its administration of this Agreement and the exercise and performance of its duties hereunder in reliance upon any Rights Certificate or certificate for Units or for other securities of the Company, instrument of assignment or
transfer, power of attorney, endorsement, affidavit, letter, notice, direction, consent, certificate, statement, or other paper or document believed by it to be genuine and to be signed, executed and, where necessary, verified or acknowledged, by
the proper Person or Persons, or otherwise upon the advice of counsel as set forth in Section 20. 
  
 
Section 19.    MERGER OR CONSOLIDATION OR CHANGE OF NAME OF RIGHTS AGENT. 
  
 (a)  Any corporation into which the Rights Agent or any successor Rights Agent may be merged or with which it may be consolidated, or any corporation resulting from any merger or consolidation to which the Rights
Agent or any successor Rights Agent shall be a party, or any corporation succeeding to the stock transfer or corporate trust business of the Rights Agent or any successor Rights Agent, shall be the successor to the Rights Agent under this Agreement
without the execution or filing of any paper or any further act on the part of any of the parties hereto; PROVIDED, that such corporation must be eligible for appointment as a successor Rights Agent under the provisions of Section 21. In case at the
time such successor Rights Agent shall succeed to the agency created by this Agreement any of the Rights Certificates shall have been countersigned but not delivered, any such successor Rights Agent may adopt the countersignature of the predecessor
Rights Agent and deliver such Rights Certificates so countersigned; and in case at that time any of the Rights Certificates shall not have been countersigned, any successor Rights Agent may countersign such Rights Certificates either in the name of
the predecessor Rights Agent or in the name of the successor Rights Agent;and in all such cases such Rights Certificates shall have the full force provided in the Rights Certificates and in this Agreement. 

 
 25 

  
 (b)  In case at any time the name of the Rights Agent
shall be changed and at such time any of the Rights Certificates shall have been countersigned but not delivered, the Rights Agent may adopt the countersignature under its prior name and deliver Rights Certificates so countersigned; and in case at
that time any of the Rights Certificates shall not have been countersigned, the Rights Agent may countersign such Rights Certificates either in its prior name or in its changed name; and in all such cases such Rights Certificates shall have the full
force provided in the Rights Certificates and in this Agreement. 
  
 
Section 20.    DUTIES OF RIGHTS AGENT.    The Rights Agent undertakes the duties and obligations imposed by this Agreement upon the following terms and conditions, all of which the
Company and the holders of Rights Certificates, by their acceptance thereof, shall be bound, and no implied duties or obligations shall be read into this Agreement against the Rights Agent: 
  
 (a)  Before the Rights Agent acts or refrains from acting, it may consult with legal counsel of its choice (who may be legal counsel for the
Company), and the advice or opinion of such counsel shall be full and complete authorization and protection to the Rights Agent as to any action taken, suffered or omitted by it in good faith and in accordance with such advice or opinion.

  
 (b)  Whenever in the administration, exercise and performance of its duties under this
Agreement the Rights Agent shall deem it necessary or desirable that any fact or matter be proved or established by the Company prior to taking, suffering or omitting any action hereunder, such fact or matter (unless other evidence in respect
thereof be herein specifically prescribed) may be deemed to be conclusively proved and established by a certificate signed by any officer of the Company and delivered to the Rights Agent; and such certificate shall be full authorization to the
Rights Agent for any action taken, suffered or omitted in good faith by it under the provisions of this Agreement in reliance upon such certificate. 
  
 (c)  The Rights Agent shall be liable hereunder to the Company and any other Person only for its own negligence or willful misconduct.

  
 (d)  The Rights Agent shall not be liable for or by reason of any of the statements of
fact or recitals contained in this Agreement or in the Rights Certificates (except its countersignature thereof) or be required to verify the same, but all such statements and recitals are and shall be deemed to have been made by the Company only.

  
 (e)  The Rights Agent shall not be under any responsibility in respect of the validity
of this Agreement or the execution and delivery hereof (except the due execution hereof by the Rights Agent) or in respect of the validity or execution of any Rights Certificate (except its countersignature thereof); nor shall it be responsible for
any breach by the Company of any covenant or condition contained in this Agreement or in any Rights Certificate; nor shall it be responsible for any change in the exercisability of the Rights (including the Rights becoming void pursuant to Section
11(a)(ii)) or any adjustment in the terms of the Rights (including the manner, method or amount thereof) provided for in Section 3, 11, 13, 23 or 24, or the ascertaining of the existence of facts that would require any such change or adjustment
(except with respect to the exercise of Rights evidenced by Rights Certificates after receipt of the 

 
 26 

 certificate described in Section 12); nor shall it by any act hereunder be deemed to make any representation or warranty
as to the authorization or reservation of any Units or other securities to be issued upon the exercise of any Rights or as to whether any such security will, when issued, be validly authorized and issued, fully paid and nonassessable. 

 
 (f)  The Company agrees that it will perform, execute, acknowledge and deliver or cause to be
performed, executed, acknowledged and delivered all such further and other acts, instruments and assurances as may reasonably be required by the Rights Agent for the carrying out or performing by the Rights Agent of the provisions of this Agreement.

  
 (g)  The Rights Agent is hereby authorized and directed to accept instructions with
respect to the administration, exercise and performance of its duties hereunder from any one officer of the Company, and to apply to such officer for advice or instructions in connection with its duties, and it shall not be responsible or liable for
any action taken, suffered or omitted by it in good faith in accordance with instructions of any such officer or for any delay in acting while waiting for those instructions. Any application by the Rights Agent for written instructions from the
Company may, at the option of the Rights Agent, set forth in writing any action proposed to be taken or omitted by the Rights Agent under this Agreement and the date on and/or after which such action shall be taken or such omission shall be
effective. The Rights Agent shall not be liable for any action taken by, or omission of, the Rights Agent in accordance with a proposal included in any such application on or after the date specified in such application (which date shall not be less
than five Business Days after the date any officer of the Company actually received such application, unless any such officer shall have consented in writing to an earlier date) unless, prior to taking any such action (or the effective date in the
case of an omission), the Rights Agent shall have received written instructions in response to such application specifying the action to be taken or omitted. 
  
 (h)  The Rights Agent and any stockholder, director, officer or employee of the Rights Agent may buy, sell or deal in any of the Rights or other
securities of the Company or become pecuniarily interested in any transaction in which the Company may be interested, or contract with or lend money to the Company or otherwise act as fully and freely as though it were not Rights Agent under this
Agreement. Nothing herein shall preclude the Rights Agent from acting in any other capacity for the Company or for any other legal entity. 
  
 (i)  The Rights Agent may execute and exercise any of the rights or powers vested in it or perform any duty under this Agreement either itself or by or through its attorneys or agents, and
the Rights Agent shall not be answerable or accountable for any act, default, neglect or misconduct of any such attorneys or agents or for any loss to the Company resulting from any such act, default, neglect or misconduct, provided reasonable care
was exercised in the selection and continued employment thereof. 
  
 (j)  No provision of
this Agreement shall require the Rights Agent to expend or risk its own funds or otherwise incur any financial liability in the performance of any of its duties hereunder or in the exercise of its rights if the Rights Agent in good faith believes
that repayment of such funds or adequate indemnification against such risk or liability is not reasonably assured to it. 

 
 27 

  
 (k)  If, with respect to any Right Certificate
surrendered to the Rights Agent for exercise, transfer or exchange, the certificate contained in the form of assignment or the form of election to purchase set forth on the reverse thereof, as the case may be, has either not been completed or in any
manner indicates any other response thereto, the Rights Agent shall not take any further action with respect to such requested exercise, transfer or exchange without first consulting with the Company. 
  
 
Section 21.    CHANGE OF RIGHTS AGENT.    The Rights Agent or any successor Rights Agent may resign and be discharged from its duties under this Agreement upon thirty days’ notice
in writing mailed to the Company and to each transfer agent of the Common Stock of the Company or Preferred Stock (as to which the Rights Agent has received prior written notice) by registered or certified mail, and the Company shall mail notice
thereof to the holders of the Rights Certificates by first-class mail. The Company may remove the Rights Agent or any successor Rights Agent upon thirty days’ notice in writing, mailed to the Rights Agent or successor Rights Agent, as the case
may be, and to each transfer agent of the Common Stock or Preferred Stock (as to which the Rights Agent has received prior written notice) by registered or certified mail, and to the holders of the Rights Certificates by first-class mail. If the
Rights Agent shall resign or be removed or shall otherwise become incapable of acting, the Company shall appoint a successor to the Rights Agent. If the Company shall fail to make such appointment within a period of thirty days after giving notice
of such removal or after it has been notified in writing of such resignation or incapacity by the resigning or incapacitated Rights Agent or by the holder of a Rights Certificate (who shall, with such notice, submit such holder’s Rights
Certificate for inspection by the Company), then the registered holder of any Rights Certificate may apply to any court of competent jurisdiction for the appointment of a new Rights Agent. Any successor Rights Agent, whether appointed by the Company
or by such a court, shall be (a) a corporation organized and doing business under the laws of the United States or of any state of the United States, in good standing, authorized under such laws to exercise corporate trust or stock transfer powers,
and subject to supervision or examination by federal or state authority and which has at the time of its appointment as Rights Agent a combined capital and surplus of at least $10,000,000 or (b) an Affiliate of a corporation described clause (a) of
this sentence. After appointment, the successor Rights Agent shall be vested with the same powers, rights, duties and responsibilities as if it had been originally named as Rights Agent without further act or deed; but the predecessor Rights Agent
shall deliver and transfer to the successor Rights Agent any property at the time held by it hereunder, and execute and deliver any further assurance, conveyance, act or deed necessary for the purpose. Not later than the effective date of any such
appointment the Company shall file notice thereof in writing with the predecessor Rights Agent and each transfer agent of the Common Stock or Preferred Stock, and mail a notice thereof in writing to the registered holders of the Rights Certificates.
Failure to give any notice provided for in this Section 21, however, or any defect therein, shall not affect the legality or validity of the resignation or removal of the Rights Agent or the appointment of the successor Rights Agent, as the case may
be. 
  
 
Section 22.    ISSUANCE OF NEW RIGHTS CERTIFICATES.    Notwithstanding any of the provisions of this Agreement or of the Rights to the contrary, the Company may, at its option, issue
new Rights Certificates evidencing Rights in such form as may be approved by its Board of Directors to reflect any adjustment or change in the Purchase Price and the number or kind or class of shares or other securities or property purchasable under
the Rights Certificates made in 

 
 28 

 accordance with the provisions of this Agreement. In addition, in connection with the issuance or sale of shares of Common Stock of the Company
following the Distribution Date and prior to the Expiration Date, the Company (a) shall, with respect to shares of Common Stock of the Company so issued or sold pursuant to the exercise of stock options or under any employee benefit plan or
arrangement or upon the exercise, conversion or exchange of securities of the Company currently outstanding or issued at any time in the future by the Company and (b) may, in any other case, if deemed necessary or appropriate by the Board of
Directors of the Company issue Rights Certificates representing the appropriate number of Rights in connection with such issuance or sale; PROVIDED, HOWEVER, that (i) no such Rights Certificate shall be issued and this sentence shall be null and
void AB INITIO if, and to the extent that, such issuance or this sentence would create a significant risk of or result in material adverse tax consequences to the Company or the Person to whom such Rights Certificate would be issued or would create
a significant risk of or result in such options’ or employee plans’ or arrangements’ failing to qualify for otherwise available special tax treatment and (ii) no such Rights Certificate shall be issued if, and to the extent that,
appropriate adjustment shall otherwise have been made in lieu of the issuance thereof. 
  
 
Section 23.    REDEMPTION AND TERMINATION. 
  
 (a)  The Company may, at its option, upon approval by the Board of Directors, at any time on or prior to the Close of Business on the earlier of (i) the Distribution Date or (ii) the Final Expiration Date (or such later
date as may be determined by its Board of Directors) redeem all but not less than all the then outstanding Rights at a redemption price of $.001 per Right, appropriately adjusted to reflect any stock split, stock dividend or similar transaction
occurring after the date of this Agreement (such redemption price being hereinafter referred to as the “REDEMPTION PRICE”), and the Company may, at its option, pay the Redemption Price either in cash, shares of Common Stock of the Company
(based on the Current Per Share Market Price thereof at the time of redemption), or any other form of consideration deemed appropriate by its Board of Directors. The redemption of the Rights by the Board of Directors of the Company may be made
effective at such time on such basis and with such conditions as the Board of Directors of the Company in its sole discretion may establish. Any such redemption will be effective immediately upon the action of the Board of Directors of the Company
ordering the same, unless such action of the Board of Directors of the Company expressly provides that such redemption will be effective at a subsequent time or upon the occurrence or nonoccurrence of one or more specified events (in which case such
redemption will be effective in accordance with the provisions of such action of the Board of Directors of the Company). 
  
 (b)  Immediately upon the effectiveness of the redemption of the Rights pursuant to Section 23(a), and without any further action and without any notice, the right to exercise the Rights will terminate and the only
right thereafter of the holders of Rights shall be to receive the Redemption Price. The Company shall promptly give public notice of any such redemption; PROVIDED, however, that the failure to give, or any defect in, any such notice shall not affect
the validity of such redemption. Within 10 calendar days after the effectiveness of the redemption of the Rights, the Company shall give notice of such redemption to the Rights Agent and shall mail a notice of redemption to all the holders of the
then outstanding Rights at their last addresses as they appear upon the registry books of the Rights Agent or, prior to the Distribution Date, on the registry books of the transfer agent for the Common Stock. Any notice 

 
 29 

 which is mailed in such manner shall be deemed given, whether or not the holder receives the notice. Each notice of
redemption will state the method by which the payment of the Redemption Price will be made. Neither the Company nor any of its Affiliates or Associates may redeem, acquire or purchase for value any Rights at any time in any manner other than that
specifically set forth in this Section 23 or in Section 24, and other than in connection with the purchase of shares of Common Stock prior to the Distribution Date. 
  
 (c)  Notwithstanding anything contained in this Agreement to the contrary, the Rights shall not be exercisable pursuant to Section 7(a) at any
time when the Rights are redeemable hereunder. 
  
 
Section 24.    EXCHANGE. 
  
 (a)  The Company,
at its option, upon approval by its Board of Directors, at any time after any Person becomes an Acquiring Person, may exchange all or part of the then outstanding and exercisable Rights (which shall not include Rights that have become void pursuant
to the provisions of Section 7(e) hereof) for Units at an exchange ratio equal to, subject to adjustment to reflect stock splits, stock dividends and similar transactions occurring after the date hereof, that number obtained by dividing the Purchase
Price by the then Current Per Share Market Price per Unit of Preferred Stock on the earlier of (i) the date on which any Person becomes an Acquiring Person and (ii) the date on which a tender or exchange offer by any Person (other than the Company,
any Subsidiary of the Company, any employee benefit plan maintained by the Company or any of its Subsidiaries or any trustee or fiduciary with respect to such plan acting in such capacity) is commenced within the meaning of Rule 14d-4(a) of the
Exchange Act Regulations or any successor rule, if upon consummation thereof such Person would be the Beneficial Owner of 15% or more of the shares of Common Stock of the Company then outstanding (such exchange ratio being hereinafter referred to as
the “SECTION 24(A) EXCHANGE RATIO”). Notwithstanding the foregoing, the Company may not effect such exchange at any time after any Person (other than the Company, any Subsidiary of the Company, any employee benefit plan maintained by the
Company or any of its Subsidiaries, or any trustee or fiduciary with respect to such plan acting in such capacity), together with all Affiliates and Associates of such Person, becomes the Beneficial Owner of 50% or more of the shares of Common Stock
of the Company then outstanding. 
  
 (b)  Immediately upon the action of the Board of
Directors of the Company ordering the exchange of any Rights pursuant to subsection (a) of this Section 24 and without any further action and without any notice, the right to exercise such Rights shall terminate and the only right thereafter of a
holder of such Rights shall be to receive that number of Units equal to the number of such Rights held by such holder multiplied by the Exchange Ratio. The Company shall promptly give public notice of any such exchange; PROVIDED, HOWEVER, that the
failure to give, or any defect in, such notice shall not affect the validity of such exchange. The Company promptly shall mail a notice of any such exchange to all of the holders of such Rights at their last addresses as they appear upon the
registry books of the Rights Agent. Any notice which is mailed in the manner provided in this Agreement shall be deemed given, whether or not the holder receives the notice. Each such notice of exchange will state the method by which the exchange of
Units for Rights will be effected and, in the event of any partial exchange, the number of Rights which will be exchanged. Any partial exchange shall be effected 

 
 30 

 pro rata based on the number of Rights (other than Rights which have become void pursuant to the provisions of Section
7(e)) held by each holder of Rights. 
  
 (c)  In the event that the number of shares of
Preferred Stock authorized by the Company’s Amended and Restated Certificate of Incorporation, as amended, but not outstanding or reserved for issuance for purposes other than upon exercise of the Rights is not sufficient to permit any exchange
of Rights as contemplated in accordance with this Section 24, the Company shall take all such action as may be necessary to authorize additional shares of Preferred Stock for issuance upon exchange of the Rights or make adequate provision to
substitute (1) cash, (2) Common Stock of the Company or other equity securities of the Company, (3) debt securities of the Company, (4) other assets, or (5) any combination of the foregoing, having an aggregate value equal to the aggregate Current
Per Share Market Price of the Units that would otherwise be issuable in such exchange, all as determined by the Board of Directors of the Company (which determination shall be described in a statement filed with the Rights Agent and shall be
conclusive and binding on the Rights Agent, the holders of the Rights and all other Persons). To the extent that the Company determines that some action need be taken pursuant to Section 24(a), the Board of Directors of the Company may temporarily
suspend the exercisability of the Rights for a period of up to sixty days following the date on which the event described in Section 24(a) shall have occurred, in order to seek any authorization of additional shares of Preferred Stock and/or to
decide the appropriate form of distribution to be made pursuant to the above provision and to determine the value thereof. In the event of any such suspension, the Company shall issue a public announcement stating that the exercisability of the
Rights has been temporarily suspended. 
  
 
Section 25.    NOTICE OF CERTAIN EVENTS. 
  
 (a)  In case the Company shall propose (i) to pay any dividend payable in stock of any class to the holders of its Preferred Stock or to make any other distribution to the holders of its Preferred Stock (other than a
regular quarterly cash dividend), (ii) to offer to the holders of its Preferred Stock rights or warrants to subscribe for or to purchase any additional Units or shares of stock of any class or any other securities, rights or options, (iii) to effect
any reclassification of its Preferred Stock (other than a reclassification involving only the subdivision of outstanding Preferred Stock), (iv) to effect any consolidation or merger into or with any other Person (other than a Subsidiary of the
Company in a transaction which complies with Section 11(o)), or to effect any sale or other transfer (or to permit one or more of its Subsidiaries to effect any sale or other transfer), in one or more transactions, of 50% or more of the assets or
earning power of the Company and its Subsidiaries (taken as a whole) to, any other Person, (v) to effect the liquidation, dissolution or winding up of the Company or (vi) to declare or pay any dividend on the Common Stock of the Company payable in
shares of Common Stock of the Company or to effect a subdivision, combination or consolidation of the shares of Common Stock of the Company (by reclassification or otherwise than by payment of dividends in shares of Common Stock), then, to the
extent feasible, the Company shall give to each holder of a Rights Certificate, in accordance with Section 26, a notice of such proposed action, which shall specify the Record Date for the purposes of such stock dividend, or distribution of rights
or warrants, or the date on which such reclassification, consolidation, merger, sale, transfer, liquidation, dissolution, or winding up is to take place and the date of participation therein by the holders of the shares of Common Stock of the
Company and/or shares of Preferred Stock, if any such date is to be fixed, 

 
 31 

 and such notice shall be so given in the case of any action covered by clause (i) or (ii) above at least ten days prior
to the Record Date for determining holders of the shares of Preferred Stock for purposes of such action, and in the case of any such other action, at least ten days prior to the date of the taking of such proposed action or the date of participation
therein by the holders of the shares of Common Stock of the Company and/or shares of Preferred Stock, whichever shall be the earlier. 
  
 (b)  In case any of the events set forth in Section 11(a)(ii) shall occur, the Company shall as soon as practicable thereafter give to each holder of a Rights Certificate, in accordance with
Section 26, a notice of the occurrence of such event, which notice shall describe such event and the consequences of such event to holders of Rights under Section 11(a)(ii). In the event any Person becomes an Acquiring Person, the Company will
promptly notify the Rights Agent thereof. 
  
 
Section 26.    NOTICES.    Notices or demands authorized by this Agreement to be given or made by the Rights Agent or by the holder of any Rights Certificate to the Company shall be
sufficiently given or made if sent by first-class mail, postage prepaid, addressed (until another address is filed in writing by the Company with the Rights Agent) as follows: 
  
 INSPIRE PHARMACEUTICALS, INC. 
 4222 Emperor
Blvd. 
 Suite 470 
 Durham,
North Carolina 27703-8466 
 Attention: Gregory J. Mossinghoff 
  
 Subject to the provisions of Section 21, any notice or demand authorized by this Agreement to be given or made by the Company or by the holder of any Rights Certificate to the Rights Agent shall be
sent by registered or certified mail and shall be deemed given upon receipt and addressed (until another address is filed in writing by the Rights Agent with the Company) as follows: 
  
 COMPUTERSHARE TRUST COMPANY 
 350 Indiana
Street, #800 
 Golden, Colorado 80401 
 Attention: Corporate Trust Department 
  
 Notices or demands authorized by this Agreement to be given or made by the Company
or the Rights Agent to the holder of any Rights Certificate shall be sufficiently given or made if sent by first-class mail, postage prepaid, addressed to such holder at the address of such holder as shown on the registry books of the Company.

  
 
Section 27.    SUPPLEMENTS AND AMENDMENTS.    Prior to the Distribution Date, the Company may supplement or amend this Agreement in any respect, without the approval of any holders of
Rights, by action of its Board of Directors. From and after the Distribution Date, the Company may from time to time supplement or amend this Agreement without the approval of any holders of Rights, by action of its Board of Directors in order (i)
to cure any ambiguity, (ii) to correct or supplement any provision contained herein which may be defective or 

 
 32 

 inconsistent with any other provisions herein, (iii) to shorten or lengthen any time period hereunder, or (iv) to change or supplement the
provisions hereunder in any manner which the Company may deem necessary or desirable and which shall not adversely affect the interests of the holders of Rights Certificates (other than an Acquiring Person or an Affiliate or Associate of an
Acquiring Person), including, without limitation, to change the Purchase Price, the Redemption Price, any time periods herein specified, and any other term hereof, any such supplement or amendment to be evidenced by a writing signed by the Company
and the Rights Agent; PROVIDED, however, that from and after such time as any Person becomes an Acquiring Person, this Agreement shall not be amended in any manner which would adversely affect the interests of the holders of Rights. Upon receipt of
a certificate from an appropriate officer of the Company that the proposed supplement or amendment is consistent with this Section 27 and, after such time as any Person has become an Acquiring Person, that the proposed supplement or amendment does
not adversely affect the interests of the holders of Rights, the Rights Agent shall execute such supplement or amendment. 
  
 
Section 28.    SUCCESSORS.    All the covenants and provisions of this Agreement by or for the benefit of the Company or the Rights Agent shall bind and inure to the benefit of their
respective successors and assigns hereunder. 
  
 
Section 29.    DETERMINATIONS AND ACTIONS BY THE BOARD OF DIRECTORS.    For all purposes of this Agreement, any calculation of the number of shares of Common Stock of the Company
outstanding at any particular time, including for purposes of determining the particular percentage of such outstanding shares of Common Stock of the Company of which any Person is the Beneficial Owner, shall be made in accordance with the last
sentence of Rule 13d-3(d)(1)(i) of the Exchange Act. The Board of Directors of the Company shall have the exclusive power and authority to administer this Agreement and to exercise all rights and powers specifically granted to the Board of
Directors, or the Company, or as may be necessary or advisable in the administration of this Agreement, including, without limitation, the right and power to (i) interpret the provisions of this Agreement and (ii) make all determinations deemed
necessary or advisable for the administration of this Agreement (including a determination to redeem or not redeem the Rights or to amend the Agreement). All such actions, calculations, interpretations and determinations (including, for purposes of
clause (y) below, all omissions with respect to the foregoing), which are done or made by the Board of Directors of the Company in good faith, shall (x) be final, conclusive and binding on the Company, the Rights Agent, the holders of the Rights
Certificates and all other parties and (y) not subject the Board of Directors of the Company to any liability to the holders of the Rights. 
  
 
Section 30.    BENEFITS OF THIS AGREEMENT.    Nothing in this Agreement shall be construed to give to any Person other than the Company, the Rights Agent and the registered holders of
the Rights Certificates (and, prior to the Distribution Date, shares of Common Stock of the Company) any legal or equitable right, remedy or claim under this Agreement; but this Agreement shall be for the sole and exclusive benefit of the Company,
the Rights Agent and the registered holders of the Rights Certificates (and, prior to the Distribution Date, shares of Common Stock of the Company). 
  
 
Section 31.    SEVERABILITY.    If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction or other authority to be invalid, void or

 
 33 

 unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect and
shall in no way be affected, impaired or invalidated; PROVIDED, HOWEVER, that notwithstanding anything in this Agreement to the contrary, if any such term, provision, covenant or restriction is held by such court or authority to be invalid, void or
unenforceable and the Board of Directors of the Company determines in its good faith judgment that severing the invalid language from this Agreement would adversely affect the purpose or effect of this Agreement and the right of redemption set forth
in Section 23 shall have expired, such right shall be reinstated and shall not expire until the tenth Business Day following the date of such determination by the Board of Directors of the Company. 
  
 
Section 32.    GOVERNING LAW.    This Agreement and each Rights Certificate issued hereunder shall be deemed to be a contract made under the laws of the State of Delaware and for all
purposes shall be governed by and construed in accordance with the internal laws of the State of Delaware applicable to contracts to be made and performed entirely within such state, without regard to the choice-of-law or conflict-of-laws principles
of any jurisdiction. 
  
 
Section 33.    COUNTERPARTS.    This Agreement may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed to be an original, and all
such counterparts shall together constitute one and the same instrument. 
  
 
Section 34.    DESCRIPTIVE HEADINGS.    Descriptive headings of the several sections of this Agreement are inserted for convenience only and shall not control or affect the meaning or
construction of any of the provisions of this Agreement. 
  
  
 [BALANCE OF PAGE
INTENTIONALLY LEFT BLANK] 

 
 34 

  
 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly
executed and attested, all as of the day and year first above written. 
  
 
	 INSPIRE PHARMACEUTICALS, INC. 
 
	 
	 By:
 	 	 /s/    GREGORY J. MOSSINGHOFF
        
 

	  	 	 Name: Gregory J. Mossinghoff
 Title: President, Secretary and
Treasurer
 
	 
	  	 	  

 
 
	 COMPUTERSHARE TRUST COMPANY AS RIGHTS AGENT 

	 
	 By:
 	 	 /s/    KELLIE GWINN
        
 

	  	 	 Name: Kellie Gwinn
 Title: Vice President
 

 
  
 
	 
	 WITNESS:
 

 
 
	 
	 By:
 	 	 /s/    DEBORAH SORHEIM
        
 

	  	 	 Name: Deborah Sorheim
 Title: Corporate Secretary
 

 
  

 
 35 

 EXHIBIT A 
  
 FORM OF 
  
 CERTIFICATE OF DESIGNATION 
  

OF 
  
 SERIES H PREFERRED STOCK

  
 OF 
  
 INSPIRE PHARMACEUTICALS, INC. 
  
 Pursuant to Section 151 of the General Corporation Law of the State of
Delaware, Inspire Pharmaceuticals, Inc. (the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of Delaware, in accordance with the provisions of Section 103 thereof, DOES HEREBY CERTIFY:

  
 That, pursuant to the authority conferred upon the Board of Directors of the Corporation by Article Fourth of the
Amended and Restated Certificate of Incorporation, as Amended, of the Corporation (the “Certificate of Incorporation”), the Board of Directors of the Corporation on June 4, 2002, adopted the following resolution creating a series of
Preferred Stock designated as Series H Preferred Stock: 
  
 RESOLVED, that, pursuant to the authority vested in the
Board of Directors of the Corporation in accordance with the provisions of the Certificate of Incorporation of the Corporation, a series of Preferred Stock of the Corporation is hereby created and that the designation and number of shares thereof
and the voting powers, preferences and relative, participating, optional and other special rights of the shares of such series, and the qualifications, limitations or restrictions thereof are as follows: 
  
 SECTION 1.    Designation and Number of Shares.    The shares of such series shall be
designated as “Series H Preferred Stock” (the “Series H Preferred Stock”), par value $0.01 per share. The number of shares initially constituting the Series H Preferred Stock shall be 60,000; provided, however, that, if more than
a total of 60,000 shares of Series H Preferred Stock shall be issuable upon the exercise of Rights (the “Rights”) issued pursuant to the Stockholders Rights Agreement dated as of October 21, 2002, between the Company and
Computershare Trust Company, as Rights Agent (the “Rights Agreement”), the Board of Directors of the Company, pursuant to Section 151 (g) of the General Company Law of the State of Delaware, shall direct by resolution or resolutions that a
certificate be properly executed, acknowledged, filed and recorded, in accordance with the provisions of Section 103 thereof, providing for the total number of shares of Series H Preferred Stock authorized to be issued to be increased (to the extent
that the Certificate of Incorporation then permits) to the largest number of whole shares (rounded up to the nearest whole number) issuable upon exercise of such Rights. 

 
 1 

  
 SECTION 2.    Dividends or Distributions.

  
 (a)  Subject to the prior and superior rights of the holders of shares of any other
series of Preferred Stock or other class of capital stock of the Company ranking prior and superior to the shares of Series H Preferred Stock with respect to dividends, the holders of shares of the Series H Preferred Stock shall be entitled to
receive, when, as and if declared by the Board of Directors, out of the assets of the Company legally available therefore, (1) quarterly dividends payable in cash on the last day of each fiscal quarter in each year, or such other dates as the Board
of Directors of the Company shall approve (each such date being referred to herein as a “Quarterly Dividend Payment Date”), commencing on the first Quarterly Dividend Payment Date after the first issuance of a share or a fraction of a
share of Series H Preferred Stock, in the amount of $.01 per whole share (rounded to the nearest cent) less the amount of all cash dividends declared on the Series H Preferred Stock pursuant to the following clause (2) since the immediately
preceding Quarterly Dividend Payment Date or, with respect to the first Quarterly Dividend Payment Date, since the first issuance of any share or fraction of a share of Series H Preferred Stock (the total of which shall not, in any event, be less
than zero) and (2) dividends payable in cash on the payment date for each cash dividend declared on the Common Stock in an amount per whole share (rounded to the nearest cent) equal to the Formula Number (as hereinafter defined) then in effect times
the cash dividends then to be paid on each share of Common Stock. In addition, if the Company shall pay any dividend or make any distribution on the Common Stock payable in assets, securities or other forms of noncash consideration (other than
dividends or distributions solely in shares of Common Stock), then, in each such case, the Company shall simultaneously pay or make on each outstanding, whole share of Series H Preferred Stock a dividend or distribution in like kind equal to the
Formula Number then in effect times such dividend or distribution on each share of the Common Stock. As used herein, the “Formula Number” shall be one one-thousandth (1/1,000); provided, however, that, if at any time after November 4,
2002, the Company shall (i) declare or pay any dividend on the Common Stock payable in shares of Common Stock or make any distribution on the Common Stock in shares of Common Stock, (ii) subdivide (by a stock split or otherwise) the outstanding
shares of Common Stock into a larger number of shares of Common Stock or (iii) combine (by a reverse stock split or otherwise) the outstanding shares of Common Stock, into a smaller number of shares of Common Stock, then in each such event the
Formula Number shall be adjusted to a number determined by multiplying the Formula Number in effect immediately prior to such event by a fraction, the numerator of which is the number of shares of Common Stock that are outstanding immediately after
such event and the denominator of which is the number of shares of Common Stock that are outstanding immediately prior to such event (and rounding the result to the nearest whole number); and provided further, that, if at any time after November 4,
2002, the Company shall issue any shares of its capital stock in a merger, reclassification, or change of the outstanding shares of Common Stock, then in each such event the Formula Number shall be appropriately adjusted to reflect such merger,
reclassification or change so that each share of Preferred Stock continues to be the economic equivalent of a Formula Number of shares of Common Stock prior to such merger, reclassification or change. 
  
 (b)  The Company shall declare a dividend or distribution on the Series H Preferred Stock as provided in Section
2(a) immediately prior to or at the same time it declares a dividend 

 
 2 

  
 or distribution on the Common Stock (other than a dividend or distribution solely
in shares of Common Stock); provided, however, that, in the event no dividend or distribution (other than a dividend or distribution in shares of Common Stock) shall have been declared on the Common Stock during the period between any Quarterly
Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a dividend of $.01 per share on the Series H Preferred Stock shall nevertheless be payable on such subsequent Quarterly Dividend Payment Date. The Board of Directors may
fix a record date for the determination of holders of shares of Series H Preferred Stock entitled to receive a dividend or distribution declared thereon, which record date shall be the same as the record date for corresponding dividend or
distribution on the Common Stock. 
  
 (c)  Dividends shall begin to accrue and be
cumulative on outstanding shares of Series H Preferred Stock from and after the Quarterly Dividend Payment Date next preceding the date of original issue of such shares of Series H Preferred Stock; provided, however, that dividends on such shares
which are originally issued after the record date for the determination of holders of shares of Series H Preferred Stock entitled to receive a quarterly dividend and on or prior to the next succeeding Quarterly Dividend Payment Date shall begin to
accrue and be cumulative from and after such Quarterly Dividend Payment Date. Notwithstanding the foregoing, dividends on shares of Series H Preferred Stock which are originally issued prior to the record date for the determination of holders of
shares of Series H Preferred Stock entitled to receive a quarterly dividend on the first Quarterly Dividend Payment Date shall be calculated as if cumulative from and after the last day of the fiscal quarter next preceding the date of original
issuance of such shares. Accrued but unpaid dividends shall not bear interest. Dividends paid on the shares of Series H Preferred Stock in an amount less than the total amount of such dividends at the time accrued and payable on such shares shall be
allocated pro rata on a share-by-share basis among all such shares at the time outstanding. 
  
 (d)  So long as any shares of the Series H Preferred Stock are outstanding, no dividends or other distributions shall be declared, paid or distributed, or set aside for payment or distribution, on the Common Stock unless,
in each case, the dividend required by this Section 2 to be declared on the Series H Preferred Stock shall have been declared. 
  
 (e)  The holders of the shares of Series H Preferred Stock shall not be entitled to receive any dividends or other distribution except as provided herein. 
  
 SECTION 3.    Voting Rights.    The holders of shares of Series H Preferred Stock shall
have the following voting rights: 
  
 (a)  Each holder of Series H Preferred Stock shall be
entitled to a number of votes equal to the Formula Number then in effect, for each share of Series H Preferred Stock held of record on each matter on which holders of the Common Stock or stockholders generally are entitled to vote, multiplied by the
maximum number of votes per share which any holder of the Common Stock or stockholders generally then have with respect to such matter (assuming, any holding period or other requirement to vote a greater number of shares is satisfied). 

 
 3 

  
 (b)  Except as otherwise provided herein or by
applicable law, the holders of shares of Series H Preferred Stock and the holders of shares of Common Stock shall vote together as one class for the election of directors of the Company and on all other matters submitted to a vote of stockholders of
the Company. 
  
 (c)  If, at the time of any annual meeting of stockholders for the
election of directors, the equivalent of six quarterly dividends (whether or not consecutive) payable on any share or shares of Series H Preferred Stock are in default, the number of directors constituting the Board of Directors of the Company shall
be increased by two. In addition to voting together with the holders of Common Stock for the election of other directors of the Company, the holders of record of the Series H Preferred Stock, voting separately as a class to the exclusion of the
holders of Common Stock, shall be entitled at said meeting of stockholders (and at each subsequent annual meeting of stockholders), unless all dividends in arrears have been paid or declared and set apart for payment prior thereto, to vote for the
election of two directors of the Company, the holders of any Series H Preferred Stock being entitled to cast a number of votes per share of Series H Preferred Stock equal to the Formula Number. Until the default in payments of all dividends which
permitted the election of said directors shall cease to exist, any director who shall have been so elected pursuant to the next preceding sentence may be removed at any time, either with or without cause, only by the affirmative vote of the holders
of the shares of Series H Preferred Stock at the time entitled to cast a majority of the votes entitled to be cast for the election of any such director at a special meeting of such holders called for that purpose, and any vacancy thereby created
may be filled by the vote of such holders. If and when such default shall cease to exist, the holders of the Series H Preferred Stock shall be divested of the foregoing special voting rights, subject to revesting in the event of each and every
subsequent like default in payments of dividends. Upon the termination of the foregoing special voting rights, the terms of office of all persons who may have been elected directors pursuant to said special voting rights shall forthwith terminate,
and the number of directors constituting the Board of Directors shall be reduced by two. The voting rights granted by this Section 3(c) shall be in addition to any other voting rights granted to the holders of the Series H Preferred Stock in this
Section 3. 
  
 (d)  Except as provided herein, in Section 11 or by applicable law, holders
of Series H Preferred Stock shall have no special voting rights and their consent shall not be required (except to the extent they are entitled to vote with holders of Common Stock as set forth herein) for authorizing or taking any corporate action.

  
 SECTION 4.    Certain Restrictions. 
  
 (a)  Whenever quarterly dividends or other dividends or distributions payable on the Series H Preferred Stock as
provided in Section 2 are in arrears, thereafter and until all accrued and unpaid dividends and distributions, whether or not declared, on shares of Series H Preferred Stock outstanding shall have been paid in full, the Company shall not:

  
 (i)  declare or pay dividends on, make any other distributions on, or redeem or
purchase or otherwise acquire for consideration any shares of stock ranking, junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series H Preferred Stock; 

 
 4 

  
 (ii)  declare or pay dividends on, or make any other
distributions on any shares of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series H Preferred Stock, except dividends paid ratably on the Series H Preferred Stock and all such parity
stock on which dividends are payable or in arrears in proportion to the total amounts to which the holders of all such shares are then entitled; 
  
 (iii)  redeem or purchase or otherwise acquire for consideration shares of any stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the
Series H Preferred Stock; provided that the Company may at any time redeem, purchase or otherwise acquire shares of any such parity stock in exchange for shares of any stock of the Company ranking junior (either as to dividends or upon dissolution,
liquidation or winding up) to the Series H Preferred Stock; or 
  
 (iv)  purchase or
otherwise acquire for consideration any shares of Series H Preferred Stock, or any shares of stock ranking on a parity with the Series H Preferred Stock, except in accordance with a purchase offer made in writing or by publication (as determined by
the Board of Directors) to all holders of such shares upon such terms as the Board of Directors, after consideration of the respective annual dividend rates and other relative rights and preferences of the respective series and classes, shall
determine in good faith will result in fair and equitable treatment among the respective series or classes. 
  
 (b)  The Company shall not permit any subsidiary of the Company to purchase or otherwise acquire for consideration any shares of stock of the Company unless the Company could, under paragraph (a) of this Section 4, purchase
or otherwise acquire such shares at such time and in such manner. 
  
 SECTION
5.    Liquidation Right.    Upon the liquidation, dissolution or winding up of the Company, whether voluntary or involuntary, no distribution shall be made (1) to the holders of shares of stock ranking
junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series H Preferred Stock unless, prior thereto, the holders of shares of Series H Preferred Stock shall have received an amount equal to the accrued and unpaid
dividends and distributions thereon, whether or not declared, to the date of such payment, plus an amount equal to the greater of (x) $.01 per whole share or (y) an aggregate amount per share equal to the Formula Number then in effect times the
aggregate amount to be distributed per share to holders of Common Stock or (2) to the holders of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series H Preferred Stock, except
distributions made ratably on the Series H Preferred Stock and all other such parity stock in proportion to the total amounts to which the holders of all such shares are entitled upon such liquidation, dissolution or winding up. 

 
 SECTION 6.    Consolidation, Merger, etc.    In case the Company shall enter
into any consolidation, merger, “business combination” or other transaction in which the shares of Common Stock are exchanged for or changed into other stock or securities, cash or any other property, then in any such case the then
outstanding shares of Series H Preferred Stock shall at the same time be similarly exchanged or changed into an amount per share equal to the Formula Number then in effect times the aggregate amount of stock, securities, cash or any other property
(payable in 

 
 5 

 kind), as the case may be, into which or for which each share of Common Stock is exchanged or changed. In the event both this Section 6 and
Section 2 appear to apply to a transaction, this Section 6 will control. 
  
 SECTION 7.    No
Redemption; No Sinking Fund. 
  
 (a)  The shares of Series H Preferred Stock shall not
be subject to redemption by the Company or at the option of any holder of Series H Preferred Stock except as set forth in the Certificate of Incorporation of the Company; provided, however, that the Company may purchase or otherwise acquire
outstanding shares of Series H Preferred Stock in the open market or by offer to any holder or holders of shares of Series H Preferred Stock. 
  
 (b)  The shares of Series H Preferred Stock shall not be subject to or entitled to the operation of a retirement or sinking fund. 
  
 SECTION 8.    Ranking.    The Series H Preferred Stock shall rank junior to all other series of Preferred Stock of the
Company, unless the Board of Directors shall specifically determine otherwise in fixing the powers, preferences and relative, participating, optional and other special rights of the shares of such series and the qualifications, limitations
and restrictions thereof. 
  
 SECTION 9.    Fractional Shares.    The
Series H Preferred Stock shall be issuable upon exercise of the Rights issued pursuant to the Rights Agreement in whole shares or in any fraction of a share that is one one-thousandths (1/1,000ths) of a share of any integral multiple of such
fraction which shall entitle the holder, in proportion to such holder’s fractional shares, to receive dividends, exercise voting rights, participate in distributions and to have the benefit of all other rights of holders of Series H Preferred
Stock. In lieu of fractional shares, the Company, prior to the first issuance of a share or a fraction of a share of Series H Preferred Stock, may elect (1) to make a cash payment as provided in the Rights Agreement for fractions of a share other
than one one-thousandths (1/1,000ths) of a share or any integral multiple thereof or (2) to issue depository receipts evidencing such authorized fraction of a share of Series H Preferred Stock pursuant to an appropriate agreement between the Company
and a depository selected by the Company; provided that such agreement shall provide that the holders of such depository receipts shall have all the rights, privileges and preferences to which they are entitled as holders of the Series H Preferred
Stock. 
  
 SECTION 10.    Reacquired Shares.    Any shares of Series H
Preferred Stock purchased or otherwise acquired by the Company in any manner whatsoever shall be retired and canceled promptly after the acquisition thereof. All such shares shall upon their cancellation become authorized but unissued shares of
Preferred Stock, without designation as to series until such shares are once more designated as part of a particular series by the Board of Directors pursuant to the provisions of Article Fourth of the Certificate of Incorporation. 

 
 SECTION 11.    Amendment.    None of the powers, preferences and relative,
participating, optional and other special rights of the Series H Preferred Stock as provided herein or in the Certificate of Incorporation shall be amended in any manner which would alter or change the powers, preferences, rights or privileges of
the holders of Series H Preferred Stock so as to affect 

 
 6 

 them adversely without the affirmative vote of the holders of at least 66-2/3% of the outstanding shares of Series H Preferred Stock, voting as
a separate class; provided, however, that no such amendment approved by the holders of at least 66-2/3% of the outstanding shares of Series H Preferred Stock shall be deemed to apply to the powers, preferences, rights or privileges of any holder of
shares of Series H Preferred Stock originally issued upon exercise of the Rights after the time of such approval without the approval of such holder. 
  
 IN WITNESS WHEREOF, the Corporation has caused this Certificate to be duly executed in its corporate name by its President, Secretary and Treasurer and attested to by its Vice President on this
         day of October, 2002. 
  
 
	 INSPIRE PHARMACEUTICALS, INC. 
 
	 
	 By:
 	 	  
	  	 	 

	  	 	 Name: Gregory J. Mossinghoff
 Title: President, Treasurer and
Secretary
 

 
  
 
	 
	 Attest:
 	 	  
	  	 	 

	  	 	 Name: Mary Bennett
 Title: Vice President
 

 
  

 
 7 

 EXHIBIT B 
  
 Form of Rights Certificate 
  
 Certificate No. R_______ ________ Rights 
  
 NOT EXERCISABLE AFTER TEN YEAR ANNIVERSARY OF RECORD DATE OR EARLIER IF REDEMPTION OR EXCHANGE OCCURS. THE RIGHTS ARE SUBJECT TO REDEMPTION AT THE
OPTION OF THE COMPANY AT $.01 PER RIGHT AND TO EXCHANGE ON THE TERMS SET FORTH IN THE RIGHTS AGREEMENT. UNDER CERTAIN CIRCUMSTANCES, RIGHTS BENEFICIALLY OWNED BY AN ACQUIRING PERSON OR AN AFFILIATE OR ASSOCIATE OF AN ACQUIRING PERSON (AS SUCH TERMS
ARE DEFINED IN THE RIGHTS AGREEMENT) AND ANY SUBSEQUENT HOLDER OF SUCH RIGHTS MAY BECOME NULL AND VOID. 
  
 Rights
Certificate 
  
 Inspire Pharmaceuticals, Inc. 
  
 This certifies that                         ,
or registered assigns, is the registered owner of the number of Rights set forth above, each of which entitles the owner thereof, subject to the terms, provisions and conditions of the Rights Agreement, dated as of October 21, 2002 (the “RIGHTS
AGREEMENT”), between Inspire Pharmaceuticals, Inc. a Delaware corporation (the “COMPANY”), and Computershare Trust Company, as Right Agent (the “RIGHTS AGENT”), to purchase from the Company at any time after the Distribution
Date (as such term is defined in the Rights Agreement) and prior to 5:00 P.M., New York City time, on November 4, 2012 at the office of the Rights Agent designated for such purpose, or at the office of its successor as Rights Agent, one
one-thousandth (a “UNIT”) of a fully paid non-assessable share of Series H Preferred Stock, par value $.001 per share (the “SERIES H PREFERRED STOCK”) of the Company, at a purchase price of $50.00 per Unit of Series H Preferred
Stock (the “PURCHASE PRICE”), upon presentation and surrender of this Rights Certificate with the Form of Election to Purchase duly executed. The number of Rights evidenced by this Rights Certificate (and the number of Units of Series H
Preferred Stock which may be purchased upon exercise hereof) set forth above, and the Purchase Price set forth above, are the number and Purchase Price as of November 4, 2002 based on the Series H Preferred Stock as constituted at such date. As
provided in the Rights Agreement, the Purchase Price and the number of Units of Series H Preferred Stock which may be purchased upon the exercise of the Rights evidenced by this Rights Certificate are subject to modification and adjustment upon the
happening of certain events. 

 
 1 

  
 This Rights Certificate is subject to all of the terms, provisions and conditions
of the Rights Agreement, which terms, provisions and conditions are hereby incorporated herein by reference and made a part hereof and to which Rights Agreement reference is hereby made for a full description of the rights, limitations of rights,
obligations, duties and immunities hereunder of the Rights Agent, the Company and the holders of the Rights Certificates. Copies of the Rights Agreement are on file at the principal executive offices of the Company. 
  
 This Rights Certificate, with or without other Rights Certificates, upon surrender at the office of the Rights Agent designated for such
purpose, may be exchanged for another Rights Certificate or Rights Certificates of like tenor and date evidencing Rights entitling the holder to purchase a like aggregate number of Series H Preferred Stock as the Rights evidenced by the Rights
Certificate or Rights Certificates surrendered shall have entitled such holder to purchase. If this Rights Certificate shall be exercised in part, the holder shall be entitled to receive upon surrender hereof another Rights Certificate or Rights
Certificates for the number of whole Rights not exercised. 
  
 Subject to the provisions of the Rights Agreement, the
Rights evidenced by this Certificate may be redeemed by the Company at a redemption price of $.001 per Right. 
  
 No
fractional shares of Series H Preferred Stock will be issued upon the exercise of any Rights or Rights evidenced hereby (other than fractions which are integral multiples of one one-thousandth of a share of Series H Preferred Stock, which may, at
the election of the Company, be evidenced by depositary receipts), but in lieu thereof a cash payment will be made, as provided in the Rights Agreement. 
  
 No holder of this Rights Certificate, as such, shall be entitled to vote or receive dividends or be deemed for any purpose the holder of Units of Series H Preferred Stock or of any other securities of
the Company which may at any time be issuable on the exercise hereof, nor shall anything contained in the Rights Agreement or herein be construed to confer upon the holder hereof, as such, any of the rights of a stockholder of the Company or any
right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold consent to any corporate action, or to receive notice of meetings or other actions affecting stockholders (except
as provided in the Rights Agreement), or to receive dividends or subscription rights, or otherwise, until the Rights or Rights evidenced by this Rights Certificate shall have been exercised as provided in the Rights Agreement. 

 
 This Rights Certificate shall not be valid or obligatory for any purpose until it shall have been countersigned by the Rights
Agent. 

 
 2 

  
 WITNESS the signature of the proper officers of the Company and its corporate
seal. Dated as of                          ,
20            . 
  
 
	 INSPIRE PHARMACEUTICALS, INC. 
 
	 
	 By:
 	 	  
	  	 	 

	  	 	 Name: Gregory J. Mossinghoff
 Title: President, Secretary and
Treasurer
 
	 
	 COUNTERSIGNED:
 

 
 
	 
	 COMPUTERSHARE TRUST COMPANY AS RIGHTS AGENT 

	 
	 By:
 	 	  
	  	 	 

	  	 	 Name: Kellie Gwinn
 Title: Vice President
 

 
  
 
	 
	 WITNESS:
 

 
 
	 
	 By:
 	 	  
	  	 	 

	  	 	 Name: Deborah Sorheim
 Title: Corporate Secretary
 

 
  

 
 3 

  
 Form of Reverse Side of Rights Certificate 
  
 FORM OF ASSIGNMENT 
  
 (To be executed by the registered holder if such holder desires to transfer the Rights Certificate.) 
  
 FOR VALUE RECEIVED                          hereby sells, assigns and transfers unto
                                        
                                   
  
 
(Please print name and address of transferee) 
  
 this Rights Certificate, together with all right, title and interest therein, and does hereby irrevocably constitute and appoint
                 Attorney, to transfer the within Rights Certificate on the books of the within-named Company, with full power of substitution. 

 
 DATED                        ,
20             
  
 
Signature 
  
 Signature
Guaranteed: 
  
 Signatures must be guaranteed by a participant in a Securities Transfer Association Inc. recognized
signature guarantee medallion program. 

 
 4 

 CERTIFICATE 
  
 The undersigned hereby certifies that the Rights evidenced by this Rights Certificate are not beneficially owned by an Acquiring Person or an Affiliate or Associate thereof (each as defined in the Rights Agreement).

  
 DATED                        , 20         

 
 
Signature 

 
 5 

 NOTICE 
  
 The signature in the foregoing Form of Assignment must conform to the name as written upon the face of this Rights Certificate in every particular, without alteration or enlargement or any change whatsoever. 
  
 In the event the certification set forth above in the Form of Assignment is not completed, the Company and the Rights Agent will deem the
beneficial owner of the Rights evidenced by this Rights Certificate to be an Acquiring Person or an Affiliate or Associate thereof (each as defined in the Rights Agreement) and such Assignment will not be honored. 

 
 6 

 FORM OF ELECTION TO PURCHASE 
  
 (To be executed if holder desires to exercise the Rights Certificate.) 
  
 To Inspire Pharmaceuticals, Inc.: 
  
 The undersigned hereby irrevocably elects to exercise Rights represented by this Rights Certificate to purchase the Units of Series H Preferred Stock issuable upon the exercise of such Rights and requests that certificates for such
Series H Preferred Stock be issued in the name of: 
  
 
(Please print name, address and social security or other identifying number) 
  
 If such number of Rights shall not be all
the Rights evidenced by this Rights Certificate, a new Rights Certificate for the balance remaining of such Rights shall be registered in the name of and delivered to: 
  
 
(Please print name, address and social security or other identifying number) 
  
 DATED                        , 20         

 
 
Signature 

 
 Signature Guaranteed: 
  
 Signatures must be guaranteed by a participant in a Securities Transfer Association Inc. recognized signature guarantee medallion program. 

 
 7 

 CERTIFICATE 
  
 The undersigned hereby certifies that the Rights evidenced by this Rights Certificate are not beneficially owned by an Acquiring Person or an Affiliate or Associate thereof (each as defined in the Rights Agreement).

  
 DATED                        , 20         

 
 
Signature 

 
 8 

 NOTICE 
  
 The signature in the foregoing Form of Election to Purchase must conform to the name as written upon the face of this Rights Certificate in every particular, without alteration or enlargement or any change whatsoever. 

 
 In the event the certification set forth above in the Form of Election to Purchase, as the case may be, is not completed, the
Company and the Rights Agent will deem the beneficial owner of the Rights evidenced by this Rights Certificate to be an Acquiring Person or an Affiliate or Associate thereof (each as defined in the Rights Agreement) and such Election to Purchase
will not be honored. 
  

 
 9 

 EXHIBIT C 
  
 INSPIRE PHARMACEUTICALS, INC. 
  
 SUMMARY OF RIGHTS TO PURCHASE 
 PREFERRED STOCK 
  
 On June 4, 2002, the Board of Directors of
Inspire Pharmaceuticals, Inc. (“Inspire” or the “Company”) declared a dividend distribution of one preferred stock purchase right (a “Right”) for each outstanding share of its common stock, $0.001 par value per share
(the “Common Stock”), of the Company held by stockholders of record on November 4, 2002 (the “Record Date”). Each Right entitles the registered holder to purchase from the Company a unit composed of one one-thousandth (1/1,000)
of a share of Series H Preferred Stock (the “Series H Preferred Stock”) of the Company, at a price of fifty dollars ($50.00) per one one-thousandth (1/1,000) of a share (the “Exercise Price”). The description and terms of the
Rights are set forth in a Rights Agreement (the “Rights Agreement”), dated as of October 21, 2002 by and between the Company and Computershare Trust Company, as rights agent (the “Rights Agent”). 
  
 As discussed below, initially the Rights will not be exercisable, certificates will not be sent to stockholders and the Rights will
automatically trade with the Common Stock. 
  
 The Rights, unless earlier redeemed by the Board of Directors, become
exercisable upon the close of business on the day (the “Distribution Date”) which is the earlier to occur of (i) the tenth (10th) day following the first date on which there is a public announcement that a person or group of affiliated or
associated persons has acquired beneficial ownership of 15% or more of the outstanding Common Stock of the Company, or (ii) 10 business days (or such later date as may be determined by action of the Company’s Board of Directors prior to such
time as any person becomes an Acquiring Person (as that term is defined in the Rights Agreement)) following the date of the commencement or announcement of a person’s or group’s intention to commence a tender offer or exchange offer, the
consummation of which would result in the ownership of 15% or more of the Company’s outstanding Common Stock. Prior to the Distribution Date, the Rights will not be exercisable, and will not be represented by a separate certificate. Instead,
the Rights will be evidenced by the Company’s Common Stock certificates outstanding as of the Record Date. 
  
 The Rights Agreement provides that, until the Distribution Date, the Rights will be transferred with, and only with, the Common Stock. Until the Distribution Date (or earlier redemption or expiration of the Rights), new Common Stock
certificates issued after the Record Date, upon transfer or new issuance of Common Stock, will contain a legend incorporating the Rights Agreement by reference. Until the Distribution Date (or earlier redemption or expiration of the Rights), the
surrender for transfer of any Common Stock certificates will also constitute the transfer of the Rights associated with the Common Stock represented by such certificate. As soon as practicable following the Distribution Date, separate certificates
evidencing the Rights will be mailed to holders of record of the Common Stock as of the close of business on the Distribution Date and, such separate certificates alone will evidence the Rights from and after the Distribution Date. The Rights are
not exercisable until the Distribution Date. 

 
 1 

  
 The Rights will expire at the close of business on November 4, 2012, unless that
final expiration date is extended or unless the Rights are earlier redeemed or exchanged by the Company, in each case as described below. 
  
 The Exercise Price payable, and the number of units of Series H Preferred Stock or other securities or property issuable, upon exercise of the Rights are subject to adjustment from time to time to prevent dilution (i) in the
event of a stock dividend on, or a subdivision, combination or reclassification of, the Series H Preferred Stock; (ii) upon the grant to holders of the units of Series H Preferred Stock of certain rights or warrants to subscribe for or purchase
units of Series H Preferred Stock at a price, or securities convertible into units of Series H Preferred Stock with a conversion price, less than the then current market price of the units of Series H Preferred Stock; or (iii) upon the distribution
to holders of the units of Series H Preferred Stock of evidences of indebtedness or assets (excluding regular periodic cash dividends paid out of earnings or retained earnings or dividends payable in units of Series H Preferred Stock) or of
subscription rights or warrants (other than those referred to above). 
  
 The number of outstanding Rights and the
number of units of Series H Preferred Stock issuable upon exercise of each Right are also subject to adjustment in the event of a stock split of the Common Stock or a stock dividend on the Common Stock payable in Common Stock or subdivisions,
consolidations or combinations of the Common Stock occurring, in any such case, prior to the Distribution Date. Units of Series H Preferred Stock purchasable upon exercise of the Rights will not be redeemable. Each unit of Series H Preferred Stock
will be entitled to an aggregate dividend of 1,000 times the dividend declared per share of Common Stock. In the event of liquidation, the holders of the units of Series H Preferred Stock will be entitled to an aggregate payment of 1,000 times the
payment made per share of Common Stock. Each unit of Series H Preferred Stock will have 1,000 votes, voting together with the Common Stock. In the event of any merger, consolidation or other transaction in which shares of Common Stock are exchanged,
each unit of Series H Preferred Stock will be entitled to receive 1,000 times the amount received per share of Common Stock. These Rights are protected by customary anti-dilution provisions. 
  
 Because of the nature of the dividend, liquidation and voting Rights, the value of each unit of Series H Preferred Stock purchasable upon exercise of each Right should
approximate the value of one share of Common Stock. 
  
 If, after the Rights become exercisable, the Company is
acquired in a merger or other business combination transaction with an Acquiring Person or one of its affiliates, or 50% or more of the Company’s consolidated assets or earning power are sold to an Acquiring Person or one of its affiliates,
proper provision will be made so that each holder of a Right will thereafter have the right to receive, upon exercise thereof at the then current Exercise Price of the Rights, that number of shares of Common Stock of the acquiring company which at
the time of such transaction will have a market value of two times the Exercise Price of the Rights. 
  
 If any
person or group of affiliated or associated persons becomes the beneficial owner of 15% or more of the outstanding stocks of Common Stock, proper provision will be made so that 

 
 2 

 each holder of a Right, other than rights beneficially owned by the Acquiring Person (which will thereafter be void), will have the right to
receive upon exercise that number of shares of Common Stock or units of Series H Preferred Stock (or cash, other securities or property) having a market value of two times the Exercise Price of the Rights. 
  
 At any time after the acquisition by a person or group of affiliated or associated persons of beneficial ownership of 15% or more of the
Company’s outstanding shares of Common Stock and prior to the acquisition by such person or group of 50% or more of the Company’s outstanding Common Stock, the Board of Directors of the Company may exchange the Rights (other than Rights
owned by such person or group which have become void), in whole or in part, at an exchange ratio per unit of Series H Preferred Stock equal to the Exercise Price divided by the then current market price per unit of Series H Preferred Stock on the
earlier of (i) the date on which any person becomes an Acquiring Person, and (ii) the date on which a tender or exchange offer is announced which, if consummated, would result in the offeror being the beneficial owner of 15% or more of the stocks of
Common Stock then outstanding. 
  
 With certain exceptions, no adjustment in the Exercise Price will be required
until cumulative adjustments require an adjustment of at least 1% in the Exercise Price. No fractional shares of Series H Preferred Stock will be issued (other than fractions which are integral multiples of one one-thousandth of a share of Series H
Preferred Stock, which may, at the election of the Company, be evidenced by depositary receipts) and, in lieu thereof, an adjustment in cash will be made based on the market price of the units of Series H Preferred Stock on the last trading day
prior to the date of exercise. 
  
 At any time on or prior to the earlier of (i) the close of business on the tenth
(10th) day after a public announcement that a person or group of affiliated or associated persons has acquired beneficial ownership of 15% or more of the Company’s outstanding Common Stock (unless the Board of Directors extends the ten-day
period); or (ii) the tenth (10th) business day following the date a person or group commences, or announces such person or group’s intention to commence, a tender offer or exchange offer that would result in the beneficial ownership of 15% or
more of the outstanding Common Stock of the Company, the Board of Directors of the Company may redeem the Rights in whole, but not in part, at a price of $.001 per Right. The redemption of the Rights may be made effective at such time on such basis
and with such conditions as the Board of Directors in its sole and absolute discretion may establish. Immediately upon the effective time of the action of the Board of Directors of the Company authorizing the redemption of the Rights, the right to
exercise the Rights will terminate and the only right of the holders of Rights will be to receive the redemption price of $.001. The Rights are also redeemable under other circumstances as specified in the Rights Agreement. 
  
 The terms of the Rights may be amended at any time and in any manner by the Board of Directors of the Company without the consent of the
holders of the Rights, except that from and after the Distribution Date no amendment may adversely affect the interests of the holders of the Rights. 

 
 3 

  
 Until a Right is exercised, the holder of a Right will have no rights by virtue
of ownership as a stockholder of the Company, including, without limitation, the right to vote or to receive dividends. 
  
 The Rights have certain anti-takeover effects. The Rights will cause substantial dilution to a person or group that attempts to acquire the Company on terms not approved by the Company’s Board of Directors, except pursuant to an
offer conditioned on a substantial number of Rights being acquired. The Rights should not interfere with any merger or other business combination approved by the Board of Directors since the Rights may be redeemed by the Company at the redemption
price of $.001 prior to the occurrence of a Distribution Date. 
  
 A copy of the Rights Agreement has been filed with
the Securities and Exchange Commission as an exhibit to a Current Report on Form 8-K. A copy of the Rights Agreement is available free of charge from the Company. This summary description of the Rights does not purport to be complete and is
qualified in its entirety by reference to the Rights Agreement, which is incorporated herein by reference. 

 
 4

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