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Exhibit 4.8    
    

THIS
WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE
REGISTRATION THEREOF UNDER SUCH ACT OR PURSUANT TO RULE 144 OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

WARRANT
TO PURCHASE STOCK 

	Corporation:	 	GENOPTIX, INC., a Delaware corporation
	Number of Shares:	 	55,205 Shares
	Class of Stock:	 	Series D Preferred Stock
	Initial Exercise Price:	 	$0.634 per share
	Issue Date:	 	May 30, 2006
	Expiration Date:	 	May 30, 2016 (Subject to Section 4.1)

        THIS
WARRANT CERTIFIES THAT, for good and valuable consideration, the receipt of which is hereby acknowledged, COMERICA BANK or its assignee ("Holder") is entitled to purchase the number
of fully paid and nonassessable shares of the class of securities (the "Shares") of the corporation (the "Company") at the initial exercise price per Share (the "Warrant Price") all as set forth above
and as adjusted pursuant to Article 2 of this warrant ("Warrant"), subject to the provisions and upon the terms and conditions set forth in this Warrant. 

ARTICLE
1.    EXERCISE.    

        1.1    Method of Exercise.    Holder may exercise this Warrant by delivering this Warrant and a duly executed Notice
of Exercise in substantially the form attached as Appendix 1 to the principal office of the Company. Holder shall also deliver to the Company a check for the aggregate Warrant Price for the
Shares being purchased. 

        1.2    Intentionally Omitted.    

        1.3    Intentionally omitted.    

        1.4    Fair Market Value.    If the Shares are traded regularly in a public market, the fair market value of the
Shares shall be the closing price of the Shares (or the closing price of the Company's stock into which the Shares are convertible) reported for the business day immediately before Holder delivers its
Notice of Exercise to the Company. If the Shares are not regularly traded in a public market, the Board of Directors of the Company shall determine fair market value in its reasonable good faith
judgment. 

        1.5    Delivery of Certificate and New Warrant.    Promptly after Holder exercises this Warrant, the Company shall
deliver to Holder certificates for the Shares acquired and, if this Warrant has not been fully exercised and has not expired, a new warrant representing the Shares not so acquired. 

        1.6    Replacement of Warrants.    On receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and amount to the Company or, in the
case of mutilation, on surrender and cancellation of this Warrant, the Company at its expense shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor. 

        1.7    Acquisition of the Company.    

        1.7.1    "Acquisition."    For the purpose of this Warrant, "Acquisition" means (a) any sale, license, or other
disposition of all or substantially all of the assets (including intellectual property) of the Company, or (b) any reorganization, consolidation, merger or sale of the voting securities of 

1

 

the
Company or any other transaction where the holders of the Company's securities before the transaction beneficially own less than 50% of the outstanding voting securities of the surviving entity
after the transaction. 

        1.7.2    Treatment of Warrant in the Event of an Acquisition.    The Company shall give Holder written notice at least
20 days prior to the closing of any proposed Acquisition. The Company will use diligent efforts to cause the acquirer of the Company under the Acquisition (the "Acquirer") to assume this
Warrant as a part of the Acquisition. 

        (A)  If
the Acquirer assumes this Warrant, then this Warrant shall be exercisable for the same securities, cash, and property as would be payable for the Shares issuable upon
exercise of the unexercised portion of this Warrant as if such Shares were outstanding on the record date for the Acquisition and subsequent closing. The Warrant Price shall be adjusted accordingly,
and the Warrant Price and number and class of Shares shall continue to be subject to adjustment from time to time in accordance with the provisions hereof. 

        (B)  If
the Acquirer refuses to assume this Warrant in connection with the Acquisition, the Company shall give Holder an additional written notice at least 5 days
prior to the closing of the Acquisition of such fact. In such event, notwithstanding any other provision of this Warrant to the contrary, Holder may immediately exercise this Warrant in the manner
specified in this Warrant with such exercise effective immediately prior to closing of the Acquisition. If Holder elects not to exercise this Warrant, then this Warrant will terminate immediately
prior to the closing of the Acquisition. 

ARTICLE
2.    ADJUSTMENTS TO THE SHARES.    

        2.1    Stock Dividends, Splits, Etc.    If the Company declares or pays a dividend on its common stock payable in
common stock, or other securities, subdivides the outstanding common stock into a greater amount of common stock, then upon exercise of this Warrant, for each Share acquired, Holder shall receive,
without cost to Holder, the total number and kind of securities to which Holder would have been entitled had Holder owned the Shares of record as of the date the dividend or subdivision occurred. 

        2.2    Reclassification, Exchange or Substitution.    Upon any reclassification, exchange, substitution, or other
event that results in a change of the number and/or class of the securities issuable upon exercise of this
Warrant, Holder shall be entitled to receive, upon exercise of this Warrant, the number and kind of securities and property that Holder would have received for the Shares if this Warrant had been
exercised immediately before such reclassification, exchange, substitution, or other event. Such an event shall include any automatic conversion of the outstanding or issuable securities of the
Company of the same class or series as the Shares to common stock pursuant to the terms of the Company's Certificate of Incorporation upon the closing of a registered public offering of the Company's
common stock. The Company or its successor shall promptly issue to Holder a new warrant for such new securities or other property. The new warrant shall provide for adjustments which shall be as
nearly equivalent as may be practicable to the adjustments provided for in this Article 2 including, without limitation, adjustments to the Warrant Price and to the number of securities or
property issuable upon exercise of the new warrant. The provisions of this Section 2.2 shall similarly apply to successive reclassifications, exchanges, substitutions, or other events. 

        2.3    Adjustments for Combinations, Etc.    If the outstanding Shares are combined or consolidated, by
reclassification or otherwise, into a lesser number of shares, the Warrant Price shall be proportionately increased. If the outstanding Shares are combined or consolidated, by reclassification or
otherwise, into a greater number of shares, the Warrant Price shall be proportionately decreased. 

2

 

        2.4    Intentionally omitted.    

        2.5    No Impairment.    The Company shall not, by amendment of its Certificate of Incorporation or through a
reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms to be observed or performed under this Warrant by the Company, but shall at all times in good faith assist in carrying out all the provisions of this Article 2 and in taking all such
action as may be necessary or appropriate to protect Holder's rights under this Article against impairment. 

        2.6    Certificate as to Adjustments.    Upon each adjustment of the Warrant Price, the Company at its expense shall
promptly compute such adjustment, and furnish Holder with a certificate of its Chief Financial Officer setting forth such adjustment and the facts upon which such adjustment is based. The Company
shall, upon written request, furnish Holder a certificate setting forth the Warrant Price in effect upon the date thereof and the series of adjustments leading to such Warrant Price. 

ARTICLE
3.    REPRESENTATIONS AND COVENANTS OF THE COMPANY.    

        3.1    Representations and Warranties.    The Company hereby represents and warrants to the Holder as follows: 

        (a)   The
initial Warrant Price referenced on the first page of this Warrant is not greater than the price per share of the Company's Series D Preferred Stock issued by
the Company to any other investor. 

        (b)   All
Shares which may be issued upon the exercise of the purchase right represented by this Warrant, and all securities, if any, issuable upon conversion of the Shares,
shall, upon issuance, be duly authorized, validly issued, fully paid and nonassessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or under
applicable federal and state securities laws. 

        (c)   The
Company's summary capitalization table attached to this Warrant is true and complete as of the Issue Date. 

        3.2    Notice of Certain Events.    If the Company proposes at any time (a) to declare any dividend or
distribution upon its common stock, whether in cash, property, stock, or other securities and whether or not a regular cash dividend; (b) to offer for subscription pro rata to the holders of
any class or series of its stock any additional shares of stock of any class or series or other rights; (c) to effect any reclassification or recapitalization of common stock; or (d) to
merge or consolidate with or into any other corporation, or sell, lease, license, or convey all or substantially all of its assets, or to liquidate, dissolve or wind up, then, in connection with each
such event, the Company shall give Holder (1) at least 20 days prior written notice of the date on which a record will be taken for such dividend, distribution, or subscription rights
(and specifying the date on which the holders of common stock will be entitled thereto) or for determining rights to vote, if any, in respect of the matters referred to in (a) and
(b) above; and (2) in the case of the matters referred to in (c) and (d) above at least 20 days prior written notice of the date when the same will take place (and
specifying the date on which the holders of common stock will be entitled to exchange their common stock for securities or other property deliverable upon the occurrence of such event). 

        3.3    Information Rights.    So long as the Holder holds this Warrant and/or any of the Shares, the Company shall
deliver to the Holder (a) promptly after mailing, copies of all communiques that are sent to all shareholders of the Company, (b) within one hundred fifty (150) days after the end
of each fiscal year of the Company, the annual audited financial statements of the Company certified by independent public accountants of recognized
standing and (c) within forty-five (45) days after the end of each of the first three quarters of each fiscal year, the Company's quarterly, unaudited financial statements. 

3

 

        3.4    Registration Under Securities Act of 1933, as amended.    The Company agrees to add Holder as a party to that
certain Amended and Restated Investor Rights Agreement dated as of May 5, 2005 by and among the Company and certain purchasers of shares of the Company's Preferred Stock ("Rights Agreement") so
that (i) shares of Common Stock issuable upon conversion of the Shares shall be "Registrable Securities" under the Rights Agreement and (ii) with the exception of Section 2.1 of
the Rights Agreement, Holder shall be considered a "Holder" for all other purposes under the Rights Agreement. 

ARTICLE
4.    REPRESENTATIONS OF HOLDER.    

        4.1    Acquisition of Warrant for Personal Account.    The Holder and its affiliates each represent and warrant that
it is acquiring the Warrant and the Shares issuable upon exercise of the Warrant solely for its account for investment and not with a view to or for sale or distribution of said Warrant or Shares
issuable upon exercise of the Warrant or any part thereof. The Holder and its affiliates also each represent that the entire legal and beneficial interests of the Warrant and Shares issuable upon
exercise of the Warrant is being acquired for, and will be held for, its account only. 

        4.2    Securities Are Not Registered.    

        4.2.1 The
Holder and its affiliates understand that the Warrant and the shares issuable upon exercise of the Warrant have not been registered under the Securities Act of
1933, as amended (the "Act") on the basis that no distribution or public offering of the stock of the Company is to be effected. The Holder and its affiliates realize that the basis for the exemption
may not be present if, notwithstanding its representations, the Holder and its affiliates have a present intention of acquiring the securities for a fixed or determinable period in the future, selling
(in connection with a distribution or otherwise), granting any participation in, or otherwise distributing the securities. The Holder and its affiliates have no such present intention. 

        4.2.2 The
Holder and its affiliates recognize that the Warrant and the shares issuable upon exercise of the Warrant must be held indefinitely unless they are subsequently
registered under the Act or an exemption from such registration is available. The Holder and its affiliates recognize that the Company has no obligation to register the Warrant or the shares issuable
upon exercise of the Warrant of the Company, or to comply with any exemption from such registration. 

        4.2.3 The
Holder and its affiliates are aware that neither the Warrant nor the shares issuable upon exercise of the Warrant may be sold pursuant to Rule 144 adopted
under the Act unless certain conditions are met, including, among other things, the existence of a public market for the shares, the availability of certain current public information about the
Company, the resale following the required holding period under Rule 144 and the number of shares being sold during any three month period not exceeding specified limitations. Holder is aware
that the conditions for resale set forth in Rule 144 have not been satisfied and that the Company presently has no plans to satisfy these conditions in the foreseeable future. 

ARTICLE
5.    MISCELLANEOUS.    

        5.1    Term; Notice of Expiration.    This Warrant is exercisable in whole or in part, at any time and from time to
time on or before the Expiration Date set forth above; provided, however, that if the Company completes its initial public offering within the three-year period immediately prior to the
Expiration Date, the Expiration Date shall automatically be extended until the third anniversary of the effective date of the Company's initial public offering. If this Warrant has not been exercised
in full on or prior to the Expiration Date, this Warrant shall terminate on the Expiration Date. 

4

 

        5.2    Legends.    This Warrant and the Shares (and the securities issuable, directly or indirectly, upon conversion
of the Shares, if any) shall be imprinted with a legend in substantially the following form: 

THIS
SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER SUCH ACT OR
PURSUANT TO RULE 144 OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

        5.3    Compliance with Securities Laws on Transfer.    This Warrant and the Shares issuable upon exercise of this
Warrant (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) may not be transferred or assigned in whole or in part without compliance with applicable federal
and state securities laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the
Company). The Company shall not require Holder to provide an opinion of counsel if the transfer is to an affiliate of Holder or if there is no material question as to the availability of current
information as referenced in Rule 144(c), Holder represents that it has complied with Rule 144(d) and (e) in reasonable detail, the selling broker represents that it has complied
with Rule 144(f), and the Company is provided with a copy of Holder's notice of proposed sale. 

        5.4    Transfer Procedure.    Subject to the provisions of Section 5.3, Holder may transfer all or part of this
Warrant or the Shares issuable upon exercise of this Warrant (or the securities issuable, directly or indirectly, upon conversion of the Shares, if any) by giving the Company notice of the portion of
the Warrant being transferred setting forth the name, address and taxpayer identification number of the transferee and surrendering this Warrant to the Company for reissuance to the transferee(s) (and
Holder, if applicable); provided, however, that, subject to the provisions of Section 5.3, Holder
may transfer all or part of this Warrant to its affiliates, including, without limitation, Comerica Incorporated, at any time with notice to the Company (which notice can be given before or after such
transfer in
accordance with Holder's normal business practices), and such affiliate shall then be entitled to all the rights of Holder under this Warrant and any related agreements, and the Company shall
cooperate fully in ensuring that any stock issued upon exercise of this Warrant is issued in the name of the affiliate that exercises the Warrant. The terms and conditions of this Warrant shall inure
to the benefit of, and be binding upon, the Company and the holders hereof and their respective permitted successors and assigns. Unless the Company is filing financial information with the Securities
and Exchange Commission pursuant to the Securities Exchange Act of 1934, the Company shall have the right to refuse to transfer any portion of this Warrant to any person or entity that directly
competes with the Company. 

        5.5    Notices.    All notices and other communications from the Company to the Holder, or vice versa, shall be deemed
delivered and effective when given personally or mailed by first-class registered or certified mail, postage prepaid, at such address as may have been furnished to the Company or the Holder, as the
case may be, in writing by the Company or such Holder from time to time. All notices to the Holder shall be addressed as follows: 

Comerica
Bank

Attn: Warrant Administrator

500 Woodward Avenue, 32nd Floor, MC 3379

Detroit, MI 48226 

        All
notices to the Company shall be addressed as follows: 

Genoptix, Inc.

2110 Rutherford Road

Carlsbad, CA 92008

Attn: Chief Financial Officer 

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        5.6    Amendments.    This Warrant and any term hereof may be changed, waived, discharged or terminated only by an
instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 

        5.7    Attorneys' Fees.    In the event of any dispute between the parties concerning the terms and provisions of this
Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys' fees. 

        5.8    Governing Law.    This Warrant shall be governed by and construed in accordance with the laws of the State of
California, without giving effect to its principles regarding conflicts of law. 

        5.9    Market Standoff.    Holder shall not sell, dispose of, transfer, make any short sale of, grant any option for
the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Common Stock (or other securities) of the Company held by Holder, for a period of time
specified by the managing underwriter(s) (not to exceed one hundred eighty (180) days) following the effective date of a registration statement of the Company filed under the Act, provided that
all executive officers and directors of the Company enter into similar agreements. Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company and/or the
managing underwriter(s) which are consistent with the foregoing or which are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose
stop-transfer instructions with respect to such Common Stock (or other securities) until the end of such period. The underwriters of the Company's stock are intended third party
beneficiaries of this Section 5.9 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

	 	 	GENOPTIX, INC.
	

 	
 	

By:	
 	

/s/ TINA S. NOVA

	 	 	Name:	 	Tina S. Nova, Ph.D.

	 	 	Title:	 	President and Chief Executive Officer

	

 	
 	

By:	
 	

/s/ DOUGLAS A. SCHULING

	 	 	Name:	 	Douglas A. Schuling

	 	 	Title:	 	Vice President and Chief Financial Officer

	

 	
 	

COMERICA BANK
	

 	
 	

By:	
 	

/s/ KILLU SANBORN

	 	 	Name:	 	Killu Sanborn

	 	 	Title:	 	Senior Vice President

Authorized
signatories under Corporate Resolutions to Borrow or an authorized signer(s) under a resolution covering warrants must sign the Warrant on behalf of the Company. 

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   APPENDIX 1  

 NOTICE OF EXERCISE  

        1.     The
undersigned hereby elects to purchase                        shares of
the                        stock of Genoptix, Inc. pursuant to the terms of the attached warrant, and
tenders herewith payment of the purchase price of such shares in full. 

        2.     Please
issue a certificate or certificates representing said shares in the name of the undersigned or in such other name as is specified below: 

Comerica
Bank

Attn: Warrant Administrator

500 Woodward Avenue, 32nd Floor, MC 3379

Detroit, MI 48226 

        1.     The
undersigned represents that (i) it is acquiring the shares solely for its own account and not as a nominee for any other party and not with a view toward the
resale or distribution thereof except in compliance with applicable securities laws; and (ii) all representations and warranties of Holder in Article 4 of the warrant are true and
correct as of the date hereof. 

	COMERICA BANK or

Registered Assignee	 	 
	

    
 (Signature)	
 	

 
	

    
 (Date)	
 	

 

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Exhibit 4.9    
    

 
 

GENOPTIX, INC.    
    
    AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT    
    

  

 
 

TABLE OF CONTENTS    
    

	 
	 	 
	 	Page

	SECTION 1.	 	GENERAL	 	1
	 	
 1.1	
 	

Definitions	
 	

1
	

SECTION 2.	
 	

REGISTRATION; RESTRICTIONS ON TRANSFER	
 	

3
	 	
 2.1	
 	

Restrictions on Transfer	
 	

3
	 	
 2.2	
 	

Demand Registration	
 	

4
	 	
 2.3	
 	

Piggyback Registrations	
 	

5
	 	
 2.4	
 	

Form S-3 Registration	
 	

6
	 	
 2.5	
 	

Expenses of Registration	
 	

7
	 	
 2.6	
 	

Obligations of the Company	
 	

7
	 	
 2.7	
 	

Termination of Registration Rights	
 	

8
	 	
 2.8	
 	

Delay of Registration; Furnishing Information	
 	

8
	 	
 2.9	
 	

Indemnification	
 	

9
	 	
 2.10	
 	

Assignment of Registration Rights	
 	

11
	 	
 2.11	
 	

Amendment of Registration Rights	
 	

11
	 	
 2.12	
 	

Limitation on Subsequent Registration Rights	
 	

11
	 	
 2.13	
 	

"Market Stand-Off" Agreement	
 	

11
	 	
 2.14	
 	

Agreement to Furnish Information	
 	

11
	 	
 2.15	
 	

Rule 144 Reporting	
 	

12
	

SECTION 3.	
 	

COVENANTS OF THE COMPANY	
 	

12
	 	
 3.1	
 	

Basic Financial Information and Reporting	
 	

12
	 	
 3.2	
 	

Inspection Rights	
 	

12
	 	
 3.3	
 	

Confidentiality of Records	
 	

13
	 	
 3.4	
 	

Reservation of Common Stock	
 	

13
	 	
 3.5	
 	

Stock Vesting	
 	

13
	 	
 3.6	
 	

Assignment of Right of First Refusal	
 	

13
	 	
 3.7	
 	

Proprietary Information and Inventions Agreement	
 	

14
	 	
 3.8	
 	

Reimbursement of Non-Employee Directors	
 	

14
	 	
 3.9	
 	

Termination of Covenants	
 	

14
	 	 	 	 	 

i

 

	

SECTION 4.	
 	

RIGHTS OF FIRST REFUSAL	
 	

14
	 	
 4.1	
 	

Subsequent Offerings	
 	

14
	 	
 4.2	
 	

Exercise of Rights	
 	

14
	 	
 4.3	
 	

Issuance of Equity Securities to Other Persons	
 	

14
	 	
 4.4	
 	

Termination and Waiver of Rights of First Refusal	
 	

15
	 	
 4.5	
 	

Excluded Securities	
 	

15
	

SECTION 5.	
 	

MISCELLANEOUS	
 	

16
	 	
 5.1	
 	

Governing Law	
 	

16
	 	
 5.2	
 	

Survival	
 	

16
	 	
 5.3	
 	

Successors and Assigns	
 	

16
	 	
 5.4	
 	

Entire Agreement	
 	

16
	 	
 5.5	
 	

Severability	
 	

16
	 	
 5.6	
 	

Amendment and Waiver	
 	

16
	 	
 5.7	
 	

Delays or Omissions	
 	

16
	 	
 5.8	
 	

Notices	
 	

17
	 	
 5.9	
 	

Attorneys' Fees	
 	

17
	 	
 5.10	
 	

Titles and Subtitles	
 	

17
	 	
 5.11	
 	

Additional Investors	
 	

17
	 	
 5.12	
 	

Counterparts	
 	

17
	 	
 5.13	
 	

Aggregation of Stock	
 	

17
	 	
 5.14	
 	

Waiver of Right of First Refusal Under Prior Agreement	
 	

17
	 	
 5.15	
 	

Amendment and Restatement of Prior Agreement	
 	

17

ii

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   GENOPTIX, INC.  

 AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT  

        THIS AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the  "Agreement") is entered
into as of the 9th day of May, 2005, by and among  GENOPTIX, INC., a Delaware corporation (the "Company"), the purchasers of the
Company's new
Series 1-D Preferred Stock (the "Series 1-D Preferred") set forth on  Exhibit A hereto and certain holders of the Company's
Series 1-A Preferred Stock (the  "Series 1-A Preferred"), Series 1-B Preferred Stock (the "Series 1-B
Preferred") and Series 1-C Preferred Stock (the "Series 1-C Preferred") set forth on  Exhibit A hereto.
The purchasers of the Series 1-D Preferred and the holders of the Series 1-A Preferred,
Series 1-B Preferred and Series 1-C Preferred shall be collectively referred to hereinafter as the "Investors" and
each individually as an "Investor".

RECITALS  

        WHEREAS, the Company proposes to sell and issue up to 11,041,015 shares of its Series 1-D
Preferred pursuant to that certain Series 1-D Preferred Stock Purchase Agreement (the "Purchase Agreement") of even date herewith
between the Company and certain Investors (the "Financing"); 

        WHEREAS, in connection with the Company's prior sale of shares of Series 1-C Preferred Stock (the  "Prior Financing"), the Company and certain Investors
entered into that certain Investors' Rights Agreement dated as of August 30, 2004 (the  "Prior Agreement"); and 

        WHEREAS, in order to induce the Company and the purchasers of the Series 1-D Preferred to enter into the Purchase
Agreement, the Investors and the Company hereby agree that the Prior Agreement shall hereby terminate and shall be superseded and replaced in its entirety by this Agreement and that this Agreement
shall govern the rights of all the Investors regarding registration rights, information rights and other rights as set forth herein. 

        NOW, THEREFORE, in consideration of the mutual promises, representations, warranties, covenants and conditions set forth in this
Agreement, the Investors who are parties to the Prior Agreement hereby agree that the Prior Agreement shall be superseded and replaced in its entirety by this Agreement, and the parties mutually agree
as follows: 

SECTION 1.    GENERAL.    

        1.1    Definitions.    As used in this Agreement the following terms shall have the following respective
meanings:

         (a)   "Exchange Act" means the Securities Exchange Act of 1934, as amended. 

        (b)   "Form S-3" means such form under the Securities Act as in effect on the date hereof or any
successor
or similar registration form under the Securities Act subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the
Company with the SEC. 

         (c)   "Holder" means any person owning of record Registrable Securities that have not been sold to the public
or any assignee
of record of such Registrable Securities in accordance with Section 2.10 hereof; provided, however, that any person owning of record Registrable
Securities described in Subsection (d) of Section 1.1(f) shall not be deemed a "Holder" for purposes of Section 2.1. 

         (d)   "Initial Offering" means the Company's first firm commitment underwritten public offering of its Common
Stock registered
under the Securities Act. 

1

 

        (e)   "Register," "registered," and "registration" refer
to a registration
effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 

         (f)    "Registrable Securities" means (a) Common Stock of the Company issued or issuable upon
conversion of the Shares,
(b) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with
respect to, or in exchange for or in replacement of, such above-described securities, (c) Common Stock of the Company purchased by certain Investors from Linda Pinney on March 6, 2000,
and (d) Common Stock of the Company issuable upon exercise (or issuable upon conversion of shares of preferred stock of the Company issuable upon exercise) of (i) that certain warrant to
purchase 12,000 shares of Series 1-A Preferred issued to Comerica Bank, originally dated as of November 26, 2002, (ii) that certain warrant to purchase 16,798 shares
of Series 1-B Preferred issued to Comerica Bank, originally dated as of November 26, 2002, and (iii) that certain warrant to purchase 276,025 shares of
Series 1-D Preferred issued to Comerica Bank in connection with the Debt Financing (as defined in the Purchase Agreement). Notwithstanding the foregoing, Registrable Securities
shall not include (x) any securities sold by a person to the public either pursuant to a registration statement or Rule 144 or sold in a private transaction in which the transferor's
rights under Section 2 of this Agreement are not assigned, and (y) any shares of Common Stock issued upon conversion of any previously outstanding Series B Preferred Stock,
Series B-1 Preferred Stock or Series B-2 Preferred Stock and any shares of Common Stock issued upon conversion of shares of Series 1-A
Preferred, Series 1-B Preferred, or Series 1-C Preferred prior to the date hereof. 

        (g)   "Registrable Securities then outstanding" shall be the number of shares determined by calculating the
total number of
shares of the Company's Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible
securities. 

         (h)   "Registration Expenses" shall mean all expenses incurred by the Company in complying with
Sections 2.2, 2.3 and
2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements not to exceed
twenty-five thousand dollars ($25,000) of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such
registration (but excluding the compensation of regular employees of the Company which shall be paid in any event by the Company). 

         (i)    "SEC" or "Commission" means the Securities
and Exchange Commission. 

         (j)    "Securities Act" shall mean the Securities Act of 1933, as amended. 

        (k)   "Selling Expenses" shall mean all underwriting discounts and selling commissions applicable to the sale.

         (l)    "Shares" shall mean shares of the Company's Series 1-A Preferred, Series 1-B
Preferred, Series 1-C Preferred and Series 1-D Preferred held by the Investors listed on Exhibit A hereto,
and each of their permitted assigns. 

        (m)  "Special Registration Statement" shall mean (i) a registration statement relating to any employee benefit
plan or
(ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, including any registration statements related to the resale of securities issued in
such a transaction or (iii) a registration related to stock issued upon conversion of debt securities. 

2

 

SECTION 2.    REGISTRATION; RESTRICTIONS ON TRANSFER.    

        2.1    Restrictions on Transfer.    

         (a)   Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities unless and until:

          (i)  There is then in effect a registration statement under the Securities Act covering such proposed disposition and such
disposition is made in accordance with such registration statement; or 

          (ii)  (A) The transferee has agreed in writing to be bound by the terms of this Agreement, (B) such Holder shall have notified the
Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably requested by
the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under
the Securities Act. After its Initial Offering, the Company will not require the transferee to be bound by the terms of this Agreement. 

        (iii)  Notwithstanding the provisions of paragraphs (i) and (ii) above, no such registration statement or opinion of counsel shall be necessary
for a transfer by a Holder that is (A) a partnership transferring to its partners or former partners in accordance with partnership interests, (B) a corporation transferring to a
wholly-owned subsidiary or a parent corporation that owns all of the capital stock of the Holder, (C) a limited liability company transferring to its members or former members in accordance
with their interest in the limited liability company, or (D) an individual transferring to the Holder's family member or trust for the benefit of an individual Holder;  provided that in each case
the transferee will be subject to the terms of this Agreement to the same extent as if such transferee were an original
Holder hereunder. 

         (b)   Each certificate representing Shares or Registrable Securities shall (unless otherwise permitted by the provisions of the Agreement) be
stamped
or otherwise imprinted with a legend substantially similar to the following (in addition to any legend required under applicable state securities laws): 

THE
SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE "ACT") AND MAY NOT BE OFFERED, SOLD OR OTHERWISE
TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH
REGISTRATION IS NOT REQUIRED. 

         (c)   The Company shall be obligated to reissue unlegended certificates at the request of any Holder thereof if the Holder shall have obtained
an
opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of
without registration, qualification or legend. 

         (d)   Any legend endorsed on an instrument pursuant to applicable state securities laws and the stop-transfer instructions with respect to
such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 

3

 

        2.2    Demand Registration.    

         (a)   Subject to the conditions of this Section 2.2, if the Company shall receive a written request from the Holders of at least thirty
percent
(30%) of the Registrable Securities (the "Initiating Holders") that the Company file a registration statement under the Securities Act covering the
registration of at least twenty percent (20%) of the Registrable Securities then outstanding (or a lesser percent if the anticipated aggregate offering price, net of underwriting discounts and
commissions, would exceed $5,000,000 (a "Qualified Public Offering")), then the Company shall, within fifteen (15) days of the receipt thereof,
give written notice of such request to all Holders, and subject to the limitations of this Section 2.2, effect, as soon as practicable using its reasonable best efforts, the registration under
the Securities Act of all Registrable Securities that the Holders request to be registered. 

         (b)   If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they
shall so
advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written
notice referred to in Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be
conditioned upon such Holder's participation in such underwriting and the inclusion of such Holder's Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to
distribute their securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company
(which underwriter or underwriters shall be reasonably acceptable to the majority in interest of the Initiating Holders). Notwithstanding any other provision of this Section 2.2 or
Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be underwritten (including Registrable Securities) then the
Company shall so advise all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be
allocated to the Holders of such Registrable Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders
(including the Initiating Holders). Any Registrable Securities excluded or withdrawn from such underwriting shall be withdrawn from the registration. 

        (c)   The Company shall not be required to effect a registration pursuant to this Section 2.2:

           (i)  prior to the earlier of (A) the fourth anniversary of the date of this Agreement or (B) one hundred eighty
(180) days
following the effective date of the registration statement pertaining to the Initial Offering; 

          (ii)  after the Company has effected two (2) registrations pursuant to this Section 2.2, and such registrations have been declared
or
ordered effective; 

       (iii)  if within thirty (30) days of receipt of a written request from Initiating Holders pursuant to Section 2.2(a), the Company gives
notice to the Holders of the Company's intention to file a registration statement for its Initial Offering or a public offering, other than pursuant to a Special Registration Statement, within ninety
(90) days; 

         (iv)  if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 2.2, a certificate signed by the
Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its shareholders for such registration
statement to be effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than one hundred twenty (120) days after receipt of the
request of the Initiating Holders; 

4

 

 provided that such right to delay a request shall be exercised by the Company not more than once in any twelve (12) month period; 

          (v)  if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on
Form S-3 pursuant to a request made pursuant to Section 2.4 below; or 

         (vi)  in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of
process in effecting such registration, qualification or compliance. 

        2.3    Piggyback Registrations.    The Company shall notify all Holders of Registrable Securities in writing at least
fifteen (15) days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to,
registration statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to include in such
registration statement all or part of such Registrable Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities
held by it shall, within fifteen (15) days after the above-described notice from the Company, so notify the Company in writing. Such notice shall state the intended method of disposition of the
Registrable Securities by such Holder. If a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall
nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to
offerings of its securities, all upon the terms and conditions set forth herein. 

        (a)    Underwriting.    If the registration statement under which the
Company gives notice under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to be
included in a registration pursuant to this Section 2.3 shall be conditioned upon such Holder's participation in such underwriting and the inclusion of such Holder's Registrable Securities in
the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form
with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the underwriter determines in good faith that marketing
factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated, first, to the Company; second, to the Holders
on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a
Holder) on a pro rata basis. No such reduction shall (i) reduce the securities being offered by the Company for its own account to be included in
the registration and underwriting, or (ii) reduce the amount of securities of the selling Holders included in the registration unless such registration does not include shares of any other
selling stockholders, in which event (x) if such registration is the Initial Offering, any or all of the Registrable Securities of the Holders may be excluded in accordance with the immediately
preceding sentence; and (y) if such registration is not the Initial Offering, a portion of the Registrable Securities of the Holders may be excluded in accordance with the immediately preceding
sentence provided that the aggregate value of the securities (including Registrable Securities) to be included in such registration by the Holders may not be so reduced to less than
twenty-five percent (25%) of the total value of all securities included in such registration. In no event will shares of any other selling stockholder be included in such registration
which would reduce the number of shares which may be included by Holders without the written consent of Holders of not less than a majority of the Registrable Securities proposed to be sold in the
offering. If any Holder disapproves of the terms of any such underwriting, such Holder may elect 

5

 

to
withdraw therefrom by written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date of the registration statement. Any Registrable
Securities excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners, retired partners and
shareholders of such Holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing person shall be deemed to be a single
"Holder," and any pro rata reduction with respect to such "Holder" shall be based upon the aggregate amount of shares carrying registration rights owned
by all entities and individuals included in such "Holder," as defined in this sentence. 

        (b)    Right to Terminate Registration.    The Company shall have the
right to terminate or withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration whether or not any Holder has elected to include
securities in such registration if the Board in good faith determines such registration should be withdrawn. The Registration Expenses of such withdrawn registration shall be borne by the Company in
accordance with Section 2.5 hereof. 

        2.4    Form S-3 Registration.    In case the Company shall receive from any Holder or Holders of
Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3) or any similar
short-form registration statement and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company
will:

        (a)   promptly give written notice of the proposed registration, and any related qualification or compliance, to all other Holders of
Registrable
Securities; and 

         (b)   as soon as practicable, effect such registration and all such qualifications and compliances as may be so requested and as would permit
or
facilitate the sale and distribution of all or such portion of such Holder's or Holders' Registrable Securities as are specified in such request, together with all or such portion of the Registrable
Securities of any other Holder or Holders joining in such request as are specified in a written request given within fifteen (15) days after receipt of such written notice from the Company;  provided,
however, that the Company shall not be obligated to effect any such registration, qualification or compliance pursuant to this
Section 2.4:

           (i)  if Form S-3 is not available for such offering by the Holders; 

          (ii)  if the Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to
sell
Registrable Securities and such other securities (if any) at an aggregate price to the public of less than one million dollars ($1,000,000); 

       (iii)  if within thirty (30) days of receipt of a written request from any Holder or Holders pursuant to this Section 2.4, the Company
gives notice to such Holder or Holders of the Company's intention to make a public offering within ninety (90) days, other than pursuant to a Special Registration Statement; 

         (iv)  if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the
good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its shareholders for such Form S-3 registration to be effected at
such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than ninety (90) days after
receipt of the request of the Holder or Holders under this Section 2.4; provided, that such right to delay a request shall be exercised by the
Company not more than once in any twelve (12) month period; 

6

 

         (v)  If the Company has within the twelve (12) month period preceding the date of such request, already effected three (3) or more
registrations on Form S-3 for any of the Holders pursuant to this Section 2.4; or 

         (vi)  in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of
process in effecting such registration, qualification or compliance. 

        (c)   Subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities and
other securities so requested to be registered as soon as practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4 shall not be counted as
demands for registration or registrations effected pursuant to Sections 2.2 or 2.3, respectively. 

        2.5    Expenses of Registration.    Except as specifically provided herein, all Registration Expenses incurred in
connection with any registration, qualification or compliance pursuant to Section 2.2 or any registration under Section 2.3 or Section 2.4 herein shall be borne by the Company.
All Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so registered pro rata on
the basis of the number of shares so registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request
of which has been subsequently withdrawn by the Initiating Holders unless the withdrawal is based upon material adverse information concerning the Company of which the Initiating Holders were not
aware at the time of such request. If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting
such registration in proportion to the number of shares for which registration was requested. 

        2.6    Obligations of the Company.    Whenever required to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible:

         (a)   Prepare and file with the SEC a registration statement with respect to such Registrable Securities and use its reasonable best efforts to
cause
such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for
(i) up to thirty (30) days with respect to any registration statement other than a registration statement on Form S-3 or (ii) up to one hundred twenty
(120) days with respect to any registration statement filed on Form S-3 or, in each case, if earlier, until the Holder or Holders have completed the distribution related
thereto; provided, however, that at any time, upon written notice to the participating Holders and for a period not to exceed sixty (60) days thereafter (the "Suspension
Period"), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of any registration statement (and the Initiating
Holders hereby agree not to offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that the Company may, in
the absence of such delay or suspension hereunder, be required under state or federal securities laws to disclose any corporate development the disclosure of which could reasonably be expected to have
an adverse effect upon the Company, its shareholders, a potentially significant transaction or event involving the Company, or any negotiations, discussions, or proposals directly relating thereto. In
the event that the Company shall exercise its rights hereunder, the applicable time period during which the registration statement is to remain effective shall be extended by a period of time equal to
the duration of the Suspension Period. The Company may extend the Suspension Period for an additional consecutive sixty (60) days with the consent of the holders of a majority of the
Registrable Securities proposed to be sold by the Initiating Holders, which consent shall not be unreasonably withheld. If so directed by the Company, the Initiating Holders shall use their reasonable
efforts to deliver to the Company 

7

 

(at
the Company's expense) all copies, other than permanent file copies then in such Initiating Holders' possession, of the prospectus relating to such Registrable Securities current at the time of
receipt of such notice. The Company shall not be required to file, cause to become effective or maintain the effectiveness of any registration statement that contemplates a distribution of securities
on a delayed or continuous basis pursuant to Rule 415 under the Securities Act. 

         (b)   Prepare and file with the SEC such amendments and supplements to such registration statement and the prospectus used in connection with
such
registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement for the period
set forth in paragraph (a) above. 

        (c)   Furnish to the Holders such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements of
the
Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

         (d)   Use its reasonable best efforts to register and qualify the securities covered by such registration statement under such other securities
or Blue
Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith
or as a condition thereto to qualify to do business or to file a general consent to service of process in any such states or jurisdictions. 

         (e)   In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary
form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 

         (f)    Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating thereto
is required to
be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a
material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. 

         (g)   Use its reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if such
securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is
customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the independent certified public
accountants of the Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 

        2.7    Termination of Registration Rights.    All registration rights granted under this Section 2 shall
terminate and be of no further force and effect four (4) years after the date of the Company's Initial Offering. In addition, a Holder's registration rights shall expire if (a) the
Company has completed its Initial Offering and is subject to the provisions of the Exchange Act, and (b) all Registrable Securities held by and issuable to such Holder (and its affiliates) may
be sold in compliance with Rule 144 (including the volume limitations set forth therein) during any ninety (90) day period. 

        2.8    Delay of Registration; Furnishing Information.    

         (a)   No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result of
any
controversy that might arise with respect to the interpretation or implementation of this Section 2. 

8

 

         (b)   It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or 2.4 that the
selling Holders shall furnish to the Company such information regarding
themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to effect the registration of their Registrable Securities. 

         (c)   The Company shall have no obligation with respect to any registration requested pursuant to Section 2.4 if, due to the operation of
subsection 2.2(b), the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or exceed the anticipated
aggregate offering price required to originally trigger the Company's obligation to initiate such registration as specified in Section 2.4, whichever is applicable. 

        2.9    Indemnification.    In the event any Registrable Securities are included in a registration statement under
Sections 2.2, 2.3 or 2.4:

         (a)   To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the partners, officers and directors of each
Holder,
any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act,
against any losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such
losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a
"Violation") by the Company: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement,
including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact
required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act,
any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration
statement; and the Company will pay as incurred to each such Holder, partner, officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in
connection with investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained
in this Section 2.9(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company,
which consent shall not be unreasonably withheld or delayed, nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of
or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, officer,
director, underwriter or controlling person of such Holder. 

         (b)   To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to
which such
registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who controls the Company within the
meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder's partners, directors or officers or any person who
controls such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or
partner, director, officer or controlling person of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims,
damages or liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent 

9

 

(and
only to the extent) that such Violation occurs in reliance upon and in conformity with written information furnished by such Holder under an instrument duly executed by such Holder and stated to
be specifically for use in connection with such registration; and each such Holder will pay as incurred any legal or other expenses reasonably incurred by the Company or any such director, officer,
controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage,
liability or action if it is judicially determined that there was such a Violation; provided, however, that the indemnity agreement contained in this
Section 2.9(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Holder, which consent
shall not be unreasonably withheld or delayed; provided further, that in no event shall any indemnity under this Section 2.9 exceed the net
proceeds from the offering received by such Holder. 

         (c)   Promptly after receipt by an indemnified party under this Section 2.9 of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.9, deliver to the indemnifying party a written
notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall
have the right to retain its own counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party
would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The failure to deliver written
notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such action, shall relieve such indemnifying party
of any liability to the indemnified party under this Section 2.9, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have
to any indemnified party otherwise than under this Section 2.9. 

         (d)   If the indemnification provided for in this Section 2.9 is held by a court of competent jurisdiction to be unavailable to an
indemnified
party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party thereunder, shall to the extent permitted by
applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect
the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s) that resulted in such loss, claim, damage or liability, as
well as any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other
things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party
and the parties' relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, that in
no event shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by such Holder. 

        (e)   The obligations of the Company and Holders under this Section 2.9 shall survive completion of any offering of Registrable Securities
in a
registration statement and the termination of this Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent
to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant 

10

 

or
plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. 

        2.10    Assignment of Registration Rights.    The rights to cause the Company to register Registrable Securities
pursuant to this Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities that (a) is a subsidiary, parent, general partner, limited partner, retired
partner, member or retired member, stockholder or shareholder of a Holder, (b) is a Holder's family member or trust for the benefit of an individual Holder, or (c) acquires at least
twenty five percent (25%) of the aggregate number of shares of Registrable Securities of a Holder as set forth on Exhibit A as of the date
hereof; or (d) is an entity affiliated by common control (or other related entity) with such Holder; provided, however,(i) the transferor
shall, within ten (10) days after such transfer, furnish to the Company written notice of the name and address of such transferee or assignee and the securities with respect to which such
registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set forth in this Agreement. 

        2.11    Amendment of Registration Rights.    Any provision of this Section 2 may be amended and the observance
thereof may be waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least a majority of
the Registrable Securities then outstanding. Any amendment or waiver effected in accordance with this Section 2.11 shall be binding upon each Holder and the Company. By acceptance of any
benefits under this Section 2, Holders of Registrable Securities hereby agree to be bound by the provisions hereunder. 

        2.12    Limitation on Subsequent Registration Rights.    Other than as provided in Section 5.11, after the date
of this Agreement, the Company shall not, without the prior written consent of the Holders of at least a majority of the Registrable Securities then outstanding, enter into any agreement with any
holder or prospective holder of any securities of the Company that would grant such holder registration rights
pari pasu with or senior to those granted to the Holders hereunder, other than the right to a Special Registration Statement. 

        2.13    "Market Stand-Off"  Agreement.    Each Holder hereby agrees that such Holder shall not sell, transfer, make
any short sale of, grant any option for the purchase
of, or enter into any hedging or similar transaction with the same economic effect as a sale with respect to any Common Stock (or other securities) of the Company held by such Holder (other than those
included in the registration) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed one hundred eighty (180) days
following the effective date of the Company's Initial Offering and ninety (90) days following any registration statement of the Company filed under the Securities Act after the Company's
Initial Offering (excluding Special Registration Statements); provided that all executive officers and directors of the Company enter into similar
agreements. 

        2.14    Agreement to Furnish Information.    Each Holder agrees to execute and deliver such other agreements as may be
reasonably requested by the Company or the underwriter that are consistent with the Holder's obligations under Section 2.13 or that are necessary to give further effect thereto. In addition, if
requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within ten (10) days of such request, such
information as may be required by the Company or such representative in connection with the completion of any public offering of the Company's securities pursuant to a registration statement filed
under the Securities Act. The obligations described in Section 2.13 and this Section 2.14 shall not apply to a Special Registration. The Company may impose stop-transfer
instructions with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of said one hundred eighty (180) day period. Each Holder agrees
that any transferee of any shares of Registrable Securities shall be bound by Sections 2.13 and 2.14. The underwriters of the Company's stock are intended third party beneficiaries of
Sections 2.13 and 2.14 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

11

           2.15    Rule 144 Reporting.    With a view to making available to the Holders
the benefits of certain rules and
regulations of the SEC which may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its best efforts to: 

        (a)   Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any
similar or analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general
public; 

        (b)   File with the SEC, in a timely manner, all reports and other documents required of the Company under the Exchange Act;
and 

        (c)   So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request: a written statement
by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting
requirements); a copy of the most recent annual or quarterly report of the Company; and such other reports and documents as a Holder may reasonably request in availing itself of any rule or regulation
of the SEC allowing it to sell any such securities without registration. 

SECTION 3.    COVENANTS OF THE COMPANY.    

        3.1    Basic Financial Information and Reporting.    

        (a)   The Company will maintain true books and records of account in which full and correct entries will be made of all its
business transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied, and will set aside on its books
all such proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied. 

        (b)   As soon as practicable after the end of each fiscal year of the Company, the Company will furnish each Investor then
holding (including and aggregating any holdings of its affiliates) at least seven hundred and fifty thousand (750,000) shares of Registrable Securities (as adjusted for any stock split,
reverse stock split or other similar event affecting the Registrable Securities) (a "Major Investor"), to the extent requested by such Major Investor, a
balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash flows of the Company, for such year, all prepared in accordance with generally
accepted accounting principles consistently applied and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial statements
shall be accompanied by a report and opinion thereon by independent public accountants of national standing selected by the Company's Board of Directors. 

        (c)   The Company will furnish each Major Investor as soon as practicable after the end of the first, second and third
quarterly accounting periods in each fiscal year of the Company, a balance sheet of the Company as of the end of each such quarterly period, and a statement of income and a statement of cash flows of
the Company for such period and for the current fiscal year to date. 

        (d)   The Company will furnish each Major Investor, (i) at least thirty (30) days prior to the beginning of each
fiscal year an annual budget and operating plans for such fiscal year (and as soon as available, any subsequent revisions thereto); and (ii) as soon as practicable after the end of each month,
a balance sheet of the Company as of the end of each such month, and a statement of income and a statement of cash flows of the Company for such month. 

        3.2    Inspection Rights.    Upon reasonable notice provided to the Company, each Major Investor shall have the right
to visit and inspect any of the properties of the Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its 

12

 

officers,
and to review such information as is reasonably requested all at such reasonable times and as often as may be reasonably requested; provided,
however, that the Company shall not be obligated under this Section 3.2 with respect to a competitor of the Company or with respect to information which the Board of
Directors determines in good faith is confidential and should not, therefore, be disclosed. 

        3.3    Confidentiality of Records.    Each Investor agrees to use, and to use its reasonable best efforts to insure
that its authorized representatives use, the same degree of care as such Investor uses to protect its own confidential information to keep confidential any information furnished to it which the
Company identifies as being confidential or proprietary (so long as such information is not in the public domain), except that such Investor may disclose such proprietary or confidential information
(i) to any partner, subsidiary or parent of such Investor for the purpose of evaluating its investment in the Company as long as such partner, subsidiary or parent is advised of the
confidentiality provisions of this Section 3.3, (ii) to the extent such disclosure is reasonably necessary for compliance with applicable court orders, governmental regulations or
regulatory filings, (iii) if such information entered the public domain subsequent to the time it was communicated to such Investor by the Company through no fault of such Investor, or
(iv) if such information was in such Investor's possession free of any obligation of confidence, as documented in writing, at the time it was communicated to such Investor by the Company. 

        3.4    Reservation of Common Stock.    The Company will at all times reserve and keep available, solely for issuance
and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

        3.5    Stock Vesting.    Other than as set forth in Section 3.6, unless otherwise approved by the Board of
Directors, all stock options and other stock equivalents issued after the date of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting as
follows: (a) twenty-five percent (25%) of such stock shall vest at the end of the first year following the earlier of the date of issuance or such person's services commencement
date with the company, and (b) seventy-five percent (75%) of such stock shall vest over the remaining three (3) years in monthly installments. With respect to any shares of
stock purchased by any such person, the Company's repurchase option shall provide that upon such person's termination of employment or service with the Company, with or without cause, the Company or
its assignee shall have the option to purchase at cost any unvested shares of stock held by such person or at the lesser of cost and the then fair market value on the date of termination of employment
or service with the Company. The stock options to be granted to employees, consultants or other service providers by the Company following the initial closing of the Financing will take into
consideration the current vesting position of such employees, consultants or other service providers in a manner to be determined by the Company's Board. 

        3.6    Assignment of Right of First Refusal.    In the event the Company elects not to exercise any right of first
refusal or right of first offer the Company may have on a proposed transfer of any of the Company's outstanding capital stock pursuant to the Company's bylaws, by contract or otherwise, the Company
shall, to the extent it may do so, assign such right of first refusal or right of first offer to each Investor. In the event of such assignment, each Investor shall have a right to purchase its  pro rata
portion of the capital stock proposed to be transferred. Each Investor's pro rata portion shall be equal to the product obtained by multiplying
(i) the aggregate number of shares proposed to be transferred by (ii) a fraction, the numerator of which is the number of shares of Registrable Securities held by such Investor at the
time of the proposed transfer and the denominator of which is the total number of shares owned by all Investors at the time of such proposed transfer. If not all Investors elect to purchase their pro
rata portion of the capital stock proposed to be transferred as described above, then the Company shall promptly notify in writing all of the Investors who do so elect and shall offer such Investors
the additional right to purchase their same pro rata portion of any remaining unclaimed shares of capital stock subject to such right of first refusal or right of first offer. 

13

 

        3.7    Proprietary Information and Inventions Agreement.    The Company will cause each person now or hereafter
employed by it with access to confidential information to enter into a proprietary information and inventions agreement substantially in the form provided to the Investors. 

        3.8    Reimbursement of Non-Employee Directors.    The Company agrees to reimburse all
non-employee directors for reasonable out-of-pocket costs incurred in connection with their membership on the Board of Directors. 

        3.9    Termination of Covenants.    All covenants of the Company contained in Section 3 of this Agreement shall
expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement pertaining to the Initial Offering or (ii) upon (a) the sale,
lease, license or other disposition of all or substantially all of the assets of the Company or (b) an acquisition of the Company by another corporation or entity by consolidation, merger or
other reorganization in which the holders of the Company's outstanding voting stock immediately prior to such transaction own, immediately after such transaction, securities representing less than
fifty percent (50%) of the voting power of the corporation or other entity surviving such transaction (a "Change in Control"). 

SECTION 4.    RIGHTS OF FIRST REFUSAL.    

        4.1    Subsequent Offerings.    Each Major Investor shall have a right of first refusal to purchase its  pro rata share of all Equity Securities, as defined below, that the Company may, from time to time, propose to sell and issue after the date of this
Agreement, other than the Equity Securities excluded by Section 4.5 hereof. Each Major Investor's pro rata share is equal to the ratio of
(a) the number of shares of the Company's Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) which such Major Investor is deemed to be a holder
immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company's outstanding Common Stock (including all shares of Common Stock issued or issuable
upon conversion of the Shares or upon the exercise of any outstanding warrants, options or other convertible or exercisable securities) immediately prior to the issuance of the Equity Securities. The
term "Equity Securities" shall mean (i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible,
with or without consideration, into any Common Stock, Preferred Stock or other security (including any option to purchase such a convertible security), (iii) any security carrying any warrant
or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such warrant or right. 

        4.2    Exercise of Rights.    If the Company proposes to issue any Equity Securities, it shall give each Major
Investor written notice of its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have
fifteen (15) days from the giving of such notice to agree to purchase its pro rata share of the Equity Securities for the price and upon the
terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of Equity Securities to be purchased. Notwithstanding the foregoing, the Company
shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal securities laws by virtue of such offer or
sale. 

        4.3    Issuance of Equity Securities to Other Persons.    If not all of the Major Investors elect to purchase their
 pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect and shall offer such
Major Investors the right to acquire such unsubscribed shares. Each of the Major Investors shall have five (5) days after receipt of such notice to notify the Company of its election to
purchase all or a portion thereof of the unsubscribed shares. If the Major Investors fail to exercise in full the rights of first refusal, the Company shall have ninety (90) days thereafter to
sell the Equity Securities in respect of which the Major Investor's rights were not exercised, at a price and upon the terms and conditions specified in the Company's notice to the Major Investors
pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities 

14

 

within
ninety (90) days of the notice provided pursuant to Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to
the Major Investors in the manner provided above. 

        4.4    Termination and Waiver of Rights of First Refusal.    The rights of first refusal established by this
Section 4 shall not apply to, and shall terminate upon the earlier of (i) the date that no Shares are outstanding, (ii) the effective date of the registration statement pertaining
to the Company's Initial Offering, or (iii) a Change in Control. The rights of first refusal established by this Section 4 may be amended, or any provision waived as permitted by
Section 5.6. 

        4.5    Excluded Securities.    The rights of first refusal established by this Section 4 shall have no
application to any of the following Equity Securities: 

        (a)   shares of Common Stock (and/or options, warrants or other Common Stock purchase rights issued pursuant to such options,
warrants or other rights) issued or to be issued after the Original Issue Date (as defined in the Company's Amended and Restated Certificate of Incorporation) to employees, officers or directors of,
or consultants or advisors to the Company or any of its affiliates, pursuant to stock purchase or stock option plans or other arrangements that are approved by the Board of Directors, including at
least two directors elected solely by the holders of a majority of the Series 1-A Preferred, Series 1-B Preferred, Series 1-C Preferred and
Series 1-D Preferred voting together as a single class on an as-if-converted basis (each, a "Preferred
Director"); 

        (b)   stock issued or issuable pursuant to any rights or agreements outstanding as of the date of this Agreement, options and
warrants outstanding as of the date of this Agreement; and stock issued pursuant to any such rights or agreements granted after the date of this Agreement;  provided that the rights of first refusal
established by this Section 4 applied with respect to the initial sale or grant by the Company of such
rights or agreements; 

        (c)   any Equity Securities issued for consideration other than cash pursuant to a merger, consolidation, strategic alliance,
acquisition or similar business combination approved by the Board of Directors, including at least two Preferred Directors; 

        (d)   shares of Common Stock issued in connection with any stock split, stock dividend or recapitalization by the Company; 

        (e)   shares of Common Stock issued upon conversion of shares of the Company's Preferred Stock; 

        (f)    any Equity Securities issued pursuant to any equipment leasing, real property leasing or loan arrangement, or debt
financing from a bank or similar financial or lending institution approved by the Board of Directors, including at least two Preferred Directors; 

        (g)   any Equity Securities that are issued by the Company pursuant to a registration statement filed under the Securities Act
in connection with an underwritten public offering; 

        (h)   any Equity Securities issued in connection with joint ventures, manufacturing, marketing or distribution arrangements or
technology transfer or development arrangements; provided that such strategic transactions and the issuance of shares therein, has been approved by the
Company's Board of Directors, including at least two Preferred Directors; 

        (i)    any Equity Securities issued by the Company pursuant to the terms of the Purchase Agreement; and 

        (j)    any Equity Securities issued in connection with any transaction or other arrangement unanimously approved by the
Company's Board of Directors. 

15

 

SECTION 5.    MISCELLANEOUS.    

        5.1    Governing Law.    This Agreement, and the rights of the parties hereto, shall be governed by and construed in
accordance with the laws of the State of Delaware as such laws apply to agreements among Delaware residents made and to be performed entirely within the State of Delaware. 

        5.2    Survival.    The representations, warranties, covenants, and agreements made herein shall survive any
investigation made by any Holder and the closing of the transactions contemplated hereby. All statements as to factual matters contained in any certificate or other instrument delivered by or on
behalf of the Company pursuant hereto in connection with the transactions contemplated hereby shall be deemed to be representations and warranties by the Company hereunder solely as of the date of
such certificate or instrument. 

        5.3    Successors and Assigns.    Except as otherwise expressly provided herein, the provisions hereof shall inure to
the benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto and shall inure to the benefit of and be enforceable by each person who shall
be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the
transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the
absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price. 

        5.4    Entire Agreement.    This Agreement, the Exhibits and Schedules hereto, the Purchase Agreement and the other
documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any
other in any manner by any representations, warranties, covenants and agreements except as specifically set forth herein and therein. 

        5.5    Severability.    In the event one or more of the provisions of this Agreement should, for any reason, be held
to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed
as if such invalid, illegal or unenforceable provision had never been contained herein. 

        5.6    Amendment and Waiver.    

        (a)   Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the
Company and the holders of a majority of the Registrable Securities. 

        (b)   Except as otherwise expressly provided, the obligations of the Company and the rights of the Holders under this Agreement
may be waived only with the written consent of the holders of at least a majority of the Registrable Securities. 

        (c)   For the purposes of determining the number of Holder or Investors entitled to vote or exercise any rights hereunder, the
Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 

        5.7    Delays or Omissions.    It is agreed that no delay or omission to exercise any right, power, or remedy accruing
to any Holder, upon any breach, default or noncompliance of the Company under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach,
default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of
any kind or character on any Holder's part of any breach, default or noncompliance under the Agreement or any waiver on such Holder's part of any provisions or conditions of this Agreement must be in
writing and shall be effective only to the extent specifically set forth in such writing. All 

16

 

remedies,
either under this Agreement, by law, or otherwise afforded to Holders, shall be cumulative and not alternative. 

        5.8    Notices.    All notices required or permitted hereunder shall be in writing and shall be deemed effectively
given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then
on the next business day; provided, in each case, that such notice is also sent by first class mail or a nationally recognized overnight courier, postage prepaid, or receipt of such electronic mail or
facsimile is confirmed by sender by telephone, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one
(1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be
notified at the address as set forth on the signature pages hereof or Exhibit A hereto or at such other address as such party may designate by ten (10) days advance written notice to the
other parties hereto. 

        5.9    Attorneys' Fees.    In the event that any suit or action is instituted to enforce any provision in this
Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect to
this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

        5.10    Titles and Subtitles.    The titles of the sections and subsections of this Agreement are for convenience of
reference only and are not to be considered in construing this Agreement. 

        5.11    Additional Investors.    Notwithstanding anything to the contrary contained herein, if the Company shall issue
Equity Securities in accordance with Section 4.5(c), (g) or (i) of this Agreement, any purchaser of such Equity Securities may become a party to this Agreement by executing and
delivering an
additional counterpart signature page to this Agreement and shall be deemed an "Investor," a "Holder"
and a party hereunder. 

        5.12    Counterparts.    This Agreement may be executed in any number of counterparts, each of which shall be an
original, but all of which together shall constitute one instrument. Facsimile copies of signed signature pages will be deemed binding originals. 

        5.13    Aggregation of Stock.    All shares of Registrable Securities held or acquired by affiliated entities or
persons or persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

        5.14    Waiver of Right of First Refusal Under Prior Agreement.    Each of the Investors who was a party to the Prior
Agreement hereby waives its rights to notice and right of first refusal under Section 4 of the Prior Agreement and any other right it may have to purchase shares of
Series 1-D Preferred under the Prior Agreement or otherwise. 

        5.15    Amendment and Restatement of Prior Agreement.    The Prior Agreement is hereby amended in its entirety and
restated herein. All provisions of, rights granted and covenants made in the Prior Agreement are hereby waived, released and terminated in their entirety and shall have no further force and effect. No
Investor under the Prior Agreement shall be deemed a party hereto unless specifically identified on Exhibit A. Upon such execution, all
provisions of, rights granted and covenants made in the Prior Agreement are hereby waived, released and terminated in their entirety and shall have no further force and effect. Notwithstanding the
foregoing, the obligations of the Investors in Section 2.1 of the Prior Agreement shall survive and remain in full force and effect with respect to those Investors in the Prior Agreement who do
not become Investors in this Agreement. 

17

   
        IN WITNESS WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT as of the date set forth in the first paragraph hereof. 

	COMPANY:	 	INVESTORS:
	
GENOPTIX, INC.	
 	

ALLIANCE TECHNOLOGY VENTURES III, L.P.
	

By:	
 	

/s/  TINA S. NOVA      
 Tina S. Nova, Ph.D.	
 	

    By: ATV III Partners, LLC

    Its: General Partner
	 	 	President, Chief Executive Officer &

Co-Founder	 	By:	/s/  MICHAEL A. HENOS      

	 	 	 	 	Name:	Michael A. Henos
	Address:	 	3398 Carmel Mountain Road

San Diego, CA 92121	 	Title:	Manager
	

 	
 	

 	
 	
ATV III AFFILIATES FUND, L.P.
	

 	
 	

 	
 	

    By: ATV III Partners, LLC

    Its: General Partner
	

 	
 	

 	
 	

By:	

/s/  MICHAEL A. HENOS      

	 	 	 	 	Name:	Michael A. Henos
	 	 	 	 	Title:	Manager
	

 	
 	

 	
 	
ENTERPRISE PARTNERS V, L.P.
	

 	
 	

 	
 	

    By: Enterprise Management Partners V, LLC

    Its: General Partner
	

 	
 	

 	
 	

By:	

/s/  ANDREW SENYEI      

	 	 	 	 	Name:	Andrew Senyei
	 	 	 	 	Title:	Managing Director
	

 	
 	

 	
 	
TULLIS-DICKERSON CAPITAL FOCUS II, L.P.
	

 	
 	

 	
 	

    By: Tullis-Dickerson Partners II, L.L.C.

    Its: General Partner
	

 	
 	

 	
 	

By:	

/s/  TIMOTHY M. BUONO      
 Timothy M. Buono, Principal

AMENDED
AND RESTATED INVESTOR RIGHTS AGREEMENT

SIGNATURE PAGE 

18

 

	 	 	 	 	TD JAVELIN CAPITAL FUND II, L.P.
	

 	
 	

 	
 	

    By: TD II Regional Partners, Inc.

    Its: General Partner
	

 	
 	

 	
 	

By:	

/s/  TIMOTHY M. BUONO      
 Timothy M. Buono, Vice President
	

 	
 	

 	
 	
TD LIGHTHOUSE CAPITAL FUND, L.P.
	

 	
 	

 	
 	

    By: TD II Regional Partners, Inc.

    Its: General Partner
	

 	
 	

 	
 	

By:	

/s/  TIMOTHY M. BUONO      
 Timothy M. Buono, Vice President
	

 	
 	

 	
 	
EXCELSIOR VENTURE PARTNERS III, LLC
	

 	
 	

 	
 	

By:	

/s/  DOUGLAS A. LINDGREN      

	 	 	 	 	Name:	Douglas A. Lindgren
	 	 	 	 	Title:	President and Chief Executive Officer
	

 	
 	

 	
 	
LOTUS BIOSCIENCE INVESTMENT HOLDINGS, LTD.
	

 	
 	

 	
 	

By:	

/s/  WONG KEN LUM          /s/  MONG CHEUK WAI      

	 	 	 	 	Name:	    WONG KEN LUM        MONG CHEUK WAI
	 	 	 	 	Title:	Directors
	

 	
 	

 	
 	
GC&H INVESTMENTS
	

 	
 	

 	
 	

By:	

/s/  JOHN L. CARDOZA      

	 	 	 	 	Name:	John L. Cardoza
	 	 	 	 	Title:	Managing Member
	

 	
 	

 	
 	
PETE HRONIS
	

 	
 	

 	
 	

/s/  PETE HRONIS      

AMENDED
AND RESTATED INVESTOR RIGHTS AGREEMENT

SIGNATURE PAGE 

19

 

	 	 	 	 	ALLEN FAMILY TRUST DATED 10/12/81
	

 	
 	

 	
 	

By:	

/s/  DICK ALLEN      

	 	 	 	 	Name:	Dick Allen
	 	 	 	 	Title:	Trustee
	

 	
 	

 	
 	
THOMAS & NELL WALTZ FAMILY L.P.
	

 	
 	

 	
 	

By:	

/s/  THOMAS A. WALTZ      

	 	 	 	 	Name:	Thomas A. Waltz
	 	 	 	 	Title:	General Partner
	

 	
 	

 	
 	
GREENE FAMILY TRUST
	

 	
 	

 	
 	

By:	
HOWARD E. GREENE, JR.

	 	 	 	 	Name:	Howard E. Greene, Jr.
	 	 	 	 	Title:	Trustee
	

 	
 	

 	
 	
ALLISON M. GREGORY
	

 	
 	

 	
 	

/s/  ALLISON M. GREGORY      

	

 	
 	

 	
 	
HARBOUR VENTURES
	

 	
 	

 	
 	

By:	

/s/  DAVID BLACKBURN      

	 	 	 	 	Name:	David Blackburn
	 	 	 	 	Title:	President
	

 	
 	

 	
 	
COMERICA INCORPORATED
	

 	
 	

 	
 	

By:	

    

	 	 	 	 	Name:	 
	 	 	 	 	Title:	 

AMENDED
AND RESTATED INVESTOR RIGHTS AGREEMENT

SIGNATURE PAGE 

20

  

 
 

SCHEDULE OF INVESTORS    
    

	Name and Address
 
	 	Series 1-A

Preferred
	 	Series 1-B

Preferred
	 	Series 1-C

Preferred
	 	Series 1-D

Preferred
	 
	

1.	
 	
ENTERPRISE PARTNERS V, L.P.

2223 Avenida de la Playa, Suite 300

La Jolla, California 92037

Attn: Andrew E. Senyei, M.D.	
 	

3,759,398	
 	

6,737,746	
 	

2,796,072	
 	

3,281,923	
 
	

2.	
 	
ALLIANCE TECHNOLOGY VENTURES III, L.P.

8995 Westside Parkway, Suite 200

Alpharetta, Georgia 30004

Attn: Michael Henos	
 	

3,684,211	
 	

3,851,743	
 	

2,025,750	
 	

2,377,748	
 
	

3.	
 	
ATV III AFFILIATES FUND, L.P.

8995 Westside Parkway, Suite 200

Alpharetta, Georgia 30004

Attn: Michael Henos	
 	

75,188	
 	

78,606	
 	

22,531	
 	

26,446	
 
	

4.	
 	
TULLIS-DICKERSON CAPITAL FOCUS II, L.P.

c/o Tullis-Dickerson & Co., Inc.

Two Greenwich Plaza, Fourth Floor

Greenwich, Connecticut 06830

Attn: Timothy M. Buono	
 	

563,910	
 	

336,886	
 	

239,942	
 	

281,635	
 
	

5.	
 	
TD JAVELIN CAPITAL FUND II, L.P.

c/o Tullis-Dickerson & Co., Inc.

Two Greenwich Plaza, Fourth Floor

Greenwich, Connecticut 06830

Attn: Timothy M. Buono	
 	

563,910	
 	

561,478	
 	

299,766	
 	

351,854	
 
	

6.	
 	
TD LIGHTHOUSE CAPITAL FUND, L.P.

c/o Tullis-Dickerson & Co., Inc.

Two Greenwich Plaza, Fourth Floor

Greenwich, Connecticut 06830

Attn: Timothy M. Buono	
 	

563,910	
 	

870,290	
 	

382,021	
 	

448,402	
 
	

7.	
 	
LOTUS BIOSCIENCE INVESTMENT HOLDINGS, LTD.

9th floor, Central Building

3 Pedder Street, Hong Kong

Attn: Tiffany Hung/Eric Chung	
 	

375,940	
 	

393,033	
 	

203,400	
 	

238,743	
 
	

8.	
 	
EXCELSIOR VENTURE PARTNERS III, LLC

c/o U.S. Trust of CT

225 High Ridge Road, East Building

Stamford, CT 06905

Attn: David I. Fann	
 	

942,481	
 	

1,403,696	
 	

620,580	
 	

728,413	
 
	

9.	
 	
ALLEN FAMILY TRUST DATED 10/12/81

4199 Campus Drive, Suite 830

Irvine, CA 92612

Attn: Dick Allen	
 	

24,000	
 	

47,000	
 	

20,000	
 	

23,475	
 
	 	 	 	 	 	 	 	 	 	 	 	 

A-1

 

	

10.	
 	
THOMAS AND NELL WALTZ FAMILY LP

6075 La Jolla Scenic Drive

La Jolla, CA 92037

Attn: Thomas A. Waltz	
 	

37,532	
 	

39,130	
 	

20,278	
 	

23,802	
 
	

11.	
 	
GREENE FAMILY TRUST

PO Box 8984

Rancho Santa Fe, CA 92067

Attn: Howard E. Greene Jr.	
 	

18,797	
 	

29,741	
 	

27,995	
 	

32,859	
 
	

12.	
 	
GC&H INVESTMENTS LLC

One Maritime Plaza

San Francisco, CA 94111

Attn: John Cardoza	
 	

75,188	
 	

78,388	
 	

40,622	
 	

47,681	
 
	

13.	
 	
PETE HRONIS

10417 Hronis Avenue

Delano, CA 93215	
 	

16,918	
 	

25,196	
 	

11,140	
 	

13,076	
 
	

14.	
 	
COMERICA INCORPORATED

c/o Technology and Life Sciences Division

Attn: Warrant Administrator

P.O. Box 7279

San Francisco, CA 94120-7279	
 	

12,000	
(1)	

16,798	
(2)	

0	
 	

276,025	
(3)
	

15.	
 	
ALLISON M. GREGORY

17549 Oak Meadow Lane

Lake Oswego, Oregon 97034	
 	

0	
 	

12,262	
 	

3,244	
 	

3,808	
 
	

16.	
 	
HARBOUR VENTURES

7946 Sitio Nispero

Carlsbad, California 92009

Attn: David Blackburn	
 	

0	
 	

11,199	
 	

5,599	
 	

6,572	
 
	
TOTALS:	
 	

10,701,383	
 	

14,476,394	
 	

6,718,940	
 	

7,886,437	
 

	(1)
	Represents
shares issuable upon exercise of that certain Warrant dated November 26, 2002, originally issued to purchase 12,000 shares of Series B Preferred Stock that
was amended in connection with the Series B-2 Preferred Stock financing to become a warrant to purchase 12,000 shares of Series B-1 Preferred, and further amended
in connection with the Series 1-C Preferred financing to become a warrant to purchase 12,000 shares of Series 1-A Preferred. Such shares are not included in the
"Totals" set forth below.

	(2)
	Represents
shares issuable upon exercise of that certain Warrant dated November 26, 2002 to purchase 16,798 shares of Series B-2 Preferred that was amended
in connection with the Series 1-C Preferred financing to become a warrant exercisable for 16,798 shares of Series 1-B Preferred. Such shares are not included in
the "Totals" set forth below.

	(3)
	Represents
shares issuable upon exercise of that certain Warrant to purchase 276,025 shares of Series 1-D Preferred issued to Comerica Bank in connection with the
Debt Financing. Such shares are not included in the "Totals" set forth below. 

A-2

QuickLinks

Exhibit 4.9

GENOPTIX, INC. AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT

TABLE OF CONTENTS

SCHEDULE OF INVESTORS

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