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Exhibit 10.9 -- ViroLogic, Inc. 2000 Equity Incentive Plan, as amended

                                 VIROLOGIC, INC.

                           2000 EQUITY INCENTIVE PLAN

                            Adopted February 21, 2000
                   Approved By Stockholders February 16, 2000
                        Amended and Restated June 7, 2000
                       Termination Date: February 21, 2010
1. PURPOSES.

        (a) AMENDMENT AND RESTATEMENT. The Plan amends and restates the
ViroLogic, Inc. 1996 Stock Plan adopted April 21, 1997 (the "PRIOR PLAN"). All
outstanding options granted under the Prior Plan also shall be amended.

        (b) ELIGIBLE STOCK AWARD RECIPIENTS. The persons eligible to receive
Stock Awards are the Employees, Directors and Consultants of the Company and its
Affiliates.

        (c) AVAILABLE STOCK AWARDS. The purpose of the Plan is to provide a
means by which eligible recipients of Stock Awards may be given an opportunity
to benefit from increases in value of the Common Stock through the granting of
the following Stock Awards: (i) Incentive Stock Options, (ii) Nonstatutory Stock
Options, (iii) stock bonuses and (iv) rights to acquire restricted stock.

        (d) GENERAL PURPOSE. The Company, by means of the Plan, seeks to retain
the services of the group of persons eligible to receive Stock Awards, to secure
and retain the services of new members of this group and to provide incentives
for such persons to exert maximum efforts for the success of the Company and its
Affiliates.

2. DEFINITIONS.

        (a) "ACCOUNTANTS" means the Company's independent certified public
accountants.

        (b) "AFFILIATE" means any parent corporation or subsidiary corporation
of the Company, whether now or hereafter existing, as those terms are defined in
Sections 424(e) and (f), respectively, of the Code.

        (c) "BOARD" means the Board of Directors of the Company.

        (d) "CAUSE" means, with respect to a Participant, the occurrence of any
of the following (and only the following): (i) conviction of such Participant of
any felony involving fraud or act of dishonesty against the Company or its
Affiliates; (ii) conduct by such Participant which, based upon good faith and
reasonable factual investigation and determination of the Company (or, if such
Participant is an Officer, of the Board), demonstrates gross unfitness to serve;
or (iii) intentional, material violation by such Participant of any statutory or
fiduciary duty of such Participant to the Company or its Affiliates. In
addition, if such Participant is not an Officer, Cause also shall include poor
performance of such Participant's services for the Company or its Affiliates as
determined by the Company following (A) written notice to such Participant
describing the nature of such deficiency and (b) such Participant's failure to
cure such deficiency within thirty (30) days following receipt of the such
written notice.

        (e) "CHANGE IN CONTROL" means: (i) a sale of all or substantially all of
the assets of the Company; (ii) a merger or consolidation in which the Company
is not the surviving corporation and in which beneficial ownership of securities
of the Company representing at least fifty percent (50%) of the combined voting
power entitled to vote in the election of Directors has changed; (iii) a reverse
merger in which the Company is the surviving corporation but the shares of
Common Stock outstanding immediately preceding the merger are converted by
virtue of the merger into other property, whether in the form of securities,
cash or otherwise, and in which beneficial ownership of securities of the
Company representing at least fifty percent (50%) of the combined voting power
entitled to vote in the election of Directors has changed; (iv) an acquisition
by any person, entity or group within the meaning of Section 13(d) or 14(d) of
the Exchange Act, or any comparable successor provisions (excluding any employee
benefit plan, or related trust, sponsored or maintained by the Company or
subsidiary of the Company or other entity controlled by the Company) of the
beneficial ownership (within the meaning of Rule 13d-3 promulgated under the
Exchange Act, or comparable successor rule) of securities of the Company
representing at least fifty percent (50%) of the combined voting power entitled
to vote in the election of Directors; or (v) in the event that the individuals
who, as of the date of adoption of the Plan, are members of the Company's Board
(the "Incumbent Board"), cease

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for any reason to constitute at least fifty percent (50%) of the Board. (If the
election, or nomination for election by the Company's stockholders, of any new
Director is approved by a vote of at least fifty percent (50%) of the Incumbent
Board, such new Director shall be considered to be a member of the Incumbent
Board in the future.)

        (f) "CODE" means the Internal Revenue Code of 1986, as amended.

        (g) "COMMITTEE" means a committee of one or more members of the Board
appointed by the Board in accordance with subsection 3(c).

        (h) "COMMON STOCK" means the common stock of the Company.

        (i) "COMPANY" means VIROLOGIC, INC., a Delaware corporation.

        (j) "CONSTRUCTIVE TERMINATION" means, with respect to a particular
Participant, the occurrence of any of the following events or conditions: (i)
(A) a change in such Participant's responsibilities which represents material
adverse change from such Participant's responsibilities as in effect at any time
within ninety (90) days preceding the date of a Change in Control or at any time
thereafter; or (B) the assignment to such Participant of any duties or
responsibilities which are materially and adversely inconsistent with such
Participant's duties and responsibilities as in effect at any time within ninety
(90) days preceding the effective date of a Change in Control or at any time
thereafter; in each case except in connection with the termination of such
Participant's Continuous Service for Cause, as a result of such Participant's
Disability or death or by such Participant other than as a result of
Constructive Termination; (ii) a material reduction in such Participant's
overall annual compensation package or any failure to pay such Participant any
compensation or benefits to which such Participant is entitled within fifteen
(15) days of the date due; (iii) the Company's requiring such Participant to
relocate to any place outside a fifty (50) mile radius of such Participant's
current work site, except for reasonably required travel on the business of the
Company or its Affiliates which is not materially greater than such travel
requirements prior to the Change in Control; (iv) the failure by the Company to
(A) continue in effect (without reduction in benefit level and/or reward
opportunities) any material compensation or employee benefit plan in which such
Participant was participating at any time within ninety (90) days preceding the
date of a Change in Control or at any time thereafter, unless such plan is
replaced with a plan that provides substantially equivalent compensation or
benefits to such Participant (it being understood that changes to any such plans
necessitated by the need to conform Participant's and the Company's other
employees', as a whole, compensation and benefits packages to those of the
surviving corporation and/or acquiror (as applicable) shall not alone constitute
Constructive Termination unless such changes result in a material reduction in
such Participant's overall annual compensation package as described in
subsection (ii) above), or (B) provide such Participant with compensation and
benefits, in the aggregate, at least substantially similar (in terms of benefit
levels and/or reward opportunities) to those provided for under each other
employee benefit plan, program and practice in which such Participant was
participating at any time within ninety (90) days preceding the date of a Change
in Control or at any time thereafter; (v) any material breach by the Company of
any material provision of an agreement between the Company and such Participant,
whether pursuant to this Plan or otherwise, other than a breach which is cured
by the Company within fifteen (15) days following notice by such Participant of
such breach; or (vi) the failure of the Company to obtain an agreement,
satisfactory to such Participant, from any successors and assigns to assume and
agree to perform the obligations created under this Plan.

        (k) "CONSULTANT" means any person, including an advisor, (i) engaged by
the Company or an Affiliate to render consulting or advisory services and who is
compensated for such services or (ii) who is a member of the Board of Directors
of an Affiliate. However, the term "Consultant" shall not include either
Directors who are not compensated by the Company for their services as Directors
or Directors who are merely paid a director's fee by the Company for their
services as Directors.

        (l) "CONTINUOUS SERVICE" means that the Participant's service with the
Company or an Affiliate, whether as an Employee, Director or Consultant, is not
interrupted or terminated. The Participant's Continuous Service shall not be
deemed to have terminated merely because of a change in the capacity in which
the Participant renders service to the Company or an Affiliate as an Employee,
Consultant or Director or a change in the entity for which the Participant
renders such service, provided that there is no interruption or termination of
the Participant's Continuous Service. For example, a change in status from an
Employee of the Company to a Consultant of an Affiliate or a Director will not
constitute an interruption of Continuous Service. The Board or the chief
executive officer of the Company, in that party's sole discretion, may determine
whether Continuous Service shall be considered interrupted in the case of any
leave of absence approved by that party, including sick leave, military leave or
any other personal leave. For purposes of Incentive Stock Options, no such leave
may exceed 90 days, unless reemployment upon expiration of such leave is
guaranteed by statute or contract, including Company policies. If reemployment
upon expiration of a leave of absence approved by the Company is not so
guaranteed, on

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the 91st day of such leave any Incentive Stock Option held by an Optionholder
shall be treated for tax purposes as a Nonstatutory Stock Option.

        (m) "COVERED EMPLOYEE" means the chief executive officer and the four
(4) other highest compensated officers of the Company for whom total
compensation is required to be reported to stockholders under the Exchange Act,
as determined for purposes of Section 162(m) of the Code.

        (n) "DIRECTOR" means a member of the Board of Directors of the Company.

        (o) "DISABILITY" means the permanent and total disability of a person
within the meaning of Section 22(e)(3) of the Code.

        (p) "EMPLOYEE" means any person employed by the Company or an Affiliate.
Mere service as a Director or payment of a director's fee by the Company or an
Affiliate shall not be sufficient to constitute "employment" by the Company or
an Affiliate.

        (q) "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

        (r) "FAIR MARKET VALUE" means, as of any date, the value of the Common
Stock determined as follows:

(i)     If the Common Stock is listed on any established stock exchange or
        traded on the Nasdaq National Market or the Nasdaq SmallCap Market, the
        Fair Market Value of a share of Common Stock shall be the closing sales
        price for such stock (or the closing bid, if no sales were reported) as
        quoted on such exchange or market (or the exchange or market with the
        greatest volume of trading in the Common Stock) on the date of
        determination, as reported in The Wall Street Journal or such other
        source as the Board deems reliable.

(ii)    In the absence of such markets for the Common Stock, the Fair Market
        Value shall be determined in good faith by the Board.

        (s) "INCENTIVE STOCK OPTION" means an Option intended to qualify as an
incentive stock option within the meaning of Section 422 of the Code and the
regulations promulgated thereunder.

        (t) "NON-EMPLOYEE DIRECTOR" means a Director who either (i) is not a
current Employee or Officer of the Company or its parent or a subsidiary, does
not receive compensation (directly or indirectly) from the Company or its parent
or a subsidiary for services rendered as a consultant or in any capacity other
than as a Director (except for an amount as to which disclosure would not be
required under Item 404(a) of Regulation S-K promulgated pursuant to the
Securities Act ("Regulation S-K")), does not possess an interest in any other
transaction as to which disclosure would be required under Item 404(a) of
Regulation S-K and is not engaged in a business relationship as to which
disclosure would be required under Item 404(b) of Regulation S-K; or (ii) is
otherwise considered a "non-employee director" for purposes of Rule 16b-3.

        (u) "NONSTATUTORY STOCK OPTION" means an Option not intended to qualify
as an Incentive Stock Option.

        (v) "OFFICER" means a person who is an officer of the Company within the
meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

        (w) "OPTION" means an Incentive Stock Option or a Nonstatutory Stock
Option granted pursuant to the Plan.

        (x) "OPTION AGREEMENT" means a written agreement between the Company and
an Optionholder evidencing the terms and conditions of an individual Option
grant. Each Option Agreement shall be subject to the terms and conditions of the
Plan.

        (y) "OPTIONHOLDER" means a person to whom an Option is granted pursuant
to the Plan or, if applicable, such other person who holds an outstanding
Option.

        (z) "OUTSIDE DIRECTOR" means a Director who either (i) is not a current
employee of the Company or an "affiliated corporation" (within the meaning of
Treasury Regulations promulgated under Section 162(m) of the Code), is not a
former employee of the Company or an "affiliated corporation" receiving
compensation for prior services (other than benefits under a tax qualified
pension plan), was not an officer of the Company or an "affiliated

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corporation" at any time and is not currently receiving direct or indirect
remuneration from the Company or an "affiliated corporation" for services in any
capacity other than as a Director or (ii) is otherwise considered an "outside
director" for purposes of Section 162(m) of the Code.

        (aa) "PARTICIPANT" means a person to whom a Stock Award is granted
pursuant to the Plan or, if applicable, such other person who holds an
outstanding Stock Award.

        (bb) "PLAN" means this VIROLOGIC, INC. 2000 Equity Incentive Plan.

        (cc) "QUALIFIED DIRECTOR" means a Non-Employee Director as of the date
of adoption of this Plan who has been invited to join the board other than in
connection with such Non-Employee Director's investment in the Company at the
time of such Non-Employee Director's election to the Board.

        (dd) "RULE 16b-3" means Rule 16b-3 promulgated under the Exchange Act or
any successor to Rule 16b-3, as in effect from time to time.

        (ee) "SECURITIES ACT" means the Securities Act of 1933, as amended.

        (ff) "STOCK AWARD" means any right granted under the Plan, including an
Option, a stock bonus and a right to acquire restricted stock.

        (gg) "STOCK AWARD AGREEMENT" means a written agreement between the
Company and a holder of a Stock Award evidencing the terms and conditions of an
individual Stock Award grant. Each Stock Award Agreement shall be subject to the
terms and conditions of the Plan.

        (hh) "TEN PERCENT STOCKHOLDER" means a person who owns (or is deemed to
own pursuant to Section 424(d) of the Code) stock possessing more than ten
percent (10%) of the total combined voting power of all classes of stock of the
Company or of any of its Affiliates.

3. ADMINISTRATION.

        (a) ADMINISTRATION BY BOARD. The Board shall administer the Plan unless
and until the Board delegates administration to a Committee, as provided in
subsection 3(c).

        (b) POWERS OF BOARD. The Board shall have the power, subject to, and
within the limitations of, the express provisions of the Plan:

(i)     To determine from time to time which of the persons eligible under the
        Plan shall be granted Stock Awards; when and how each Stock Award shall
        be granted; what type or combination of types of Stock Award shall be
        granted; the provisions of each Stock Award granted (which need not be
        identical), including the time or times when a person shall be permitted
        to receive Common Stock pursuant to a Stock Award; and the number of
        shares of Common Stock with respect to which a Stock Award shall be
        granted to each such person.

(ii)    To construe and interpret the Plan and Stock Awards granted under it,
        and to establish, amend and revoke rules and regulations for its
        administration. The Board, in the exercise of this power, may correct
        any defect, omission or inconsistency in the Plan or in any Stock Award
        Agreement, in a manner and to the extent it shall deem necessary or
        expedient to make the Plan fully effective.

(iii)   To amend the Plan or a Stock Award as provided in Section 12.

(iv)    Generally, to exercise such powers and to perform such acts as the Board
        deems necessary or expedient to promote the best interests of the
        Company which are not in conflict with the provisions of the Plan.

        (c) DELEGATION TO COMMITTEE.

(i)     GENERAL. The Board may delegate administration of the Plan to a
        Committee or Committees of one (1) or more members of the Board, and the
        term "Committee" shall apply to any person or persons to whom such
        authority has been delegated. If administration is delegated to a
        Committee, the Committee shall have, in connection with the
        administration of the Plan, the powers theretofore possessed by the
        Board, including the power to delegate to a subcommittee any of the
        administrative powers the Committee is authorized to exercise (and

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        references in this Plan to the Board shall thereafter be to the
        Committee or subcommittee), subject, however, to such resolutions, not
        inconsistent with the provisions of the Plan, as may be adopted from
        time to time by the Board. The Board may abolish the Committee at any
        time and revest in the Board the administration of the Plan.

(ii)    COMMITTEE COMPOSITION WHEN COMMON STOCK IS PUBLICLY TRADED. At such time
        as the Common Stock is publicly traded, in the discretion of the Board,
        a Committee may consist solely of two or more Outside Directors, in
        accordance with Section 162(m) of the Code, and/or solely of two or more
        Non-Employee Directors, in accordance with Rule 16b-3. Within the scope
        of such authority, the Board or the Committee may (1) delegate to a
        committee of one or more members of the Board who are not Outside
        Directors the authority to grant Stock Awards to eligible persons who
        are either (a) not then Covered Employees and are not expected to be
        Covered Employees at the time of recognition of income resulting from
        such Stock Award or (b) not persons with respect to whom the Company
        wishes to comply with Section 162(m) of the Code and/or (2) delegate to
        a committee of one or more members of the Board who are not Non-Employee
        Directors the authority to grant Stock Awards to eligible persons who
        are not then subject to Section 16 of the Exchange Act.

        (d) EFFECT OF BOARD'S DECISION. All determinations, interpretations and
constructions made by the Board in good faith shall not be subject to review by
any person and shall be final, binding and conclusive on all persons.

4. SHARES SUBJECT TO THE PLAN.

        (a) SHARE RESERVE. Subject to the provisions of Section 11 relating to
adjustments upon changes in Common Stock, the Common Stock that may be issued
pursuant to Stock Awards shall not exceed in the aggregate four million two
hundred thousand (4,200,000) shares of Common Stock.

        (b) REVERSION OF SHARES TO THE SHARE RESERVE. If any Stock Award shall
for any reason expire or otherwise terminate, in whole or in part, without
having been exercised in full, the shares of Common Stock not acquired under
such Stock Award shall revert to and again become available for issuance under
the Plan.

        (c) SOURCE OF SHARES. The shares of Common Stock subject to the Plan may
be unissued shares or reacquired shares, bought on the market or otherwise.

5. ELIGIBILITY.

        (a) ELIGIBILITY FOR SPECIFIC STOCK AWARDS. Incentive Stock Options may
be granted only to Employees. Stock Awards other than Incentive Stock Options
may be granted to Employees, Directors and Consultants.

        (b) TEN PERCENT STOCKHOLDERS. A Ten Percent Stockholder shall not be
granted an Incentive Stock Option unless the exercise price of such Option is at
least one hundred ten percent (110%) of the Fair Market Value of the Common
Stock at the date of grant and the Option is not exercisable after the
expiration of five (5) years from the date of grant.

        (c) SECTION 162(m) LIMITATION. Subject to the provisions of Section 11
relating to adjustments upon changes in the shares of Common Stock, no Employee
shall be eligible to be granted Options covering more than one million
(1,000,000) shares of Common Stock during any calendar year.

        (d) CONSULTANTS.

(i)     A Consultant shall not be eligible for the grant of a Stock Award if, at
        the time of grant, a Form S-8 Registration Statement under the
        Securities Act ("Form S-8") is not available to register either the
        offer or the sale of the Company's securities to such Consultant because
        of the nature of the services that the Consultant is providing to the
        Company, or because the Consultant is not a natural person, or as
        otherwise provided by the rules governing the use of Form S-8, unless
        the Company determines both (i) that such grant (A) shall be registered
        in another manner under the Securities Act (e.g., on a Form S-3
        Registration Statement) or (B) does not require registration under the
        Securities Act in order to comply with the requirements of the
        Securities Act, if applicable, and (ii) that such grant complies with
        the securities laws of all other relevant jurisdictions.

(ii)    Form S-8 generally is available to consultants and advisors only if (i)
        they are natural persons; (ii) they provide bona fide services to the
        issuer, its parents, its majority-owned subsidiaries or majority-owned
        subsidiaries of the issuer's parent; and (iii) the services are not in
        connection with the offer or sale of securities in a capital-raising
        transaction, and do not directly or indirectly promote or maintain a
        market for the issuer's securities.

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6. OPTION PROVISIONS.

        Each Option shall be in such form and shall contain such terms and
conditions as the Board shall deem appropriate. All Options shall be separately
designated Incentive Stock Options or Nonstatutory Stock Options at the time of
grant, and, if certificates are issued, a separate certificate or certificates
will be issued for shares of Common Stock purchased on exercise of each type of
Option. The provisions of separate Options need not be identical, but each
Option shall include (through incorporation of provisions hereof by reference in
the Option or otherwise) the substance of each of the following provisions:

        (a) TERM. Subject to the provisions of subsection 5(b) regarding Ten
Percent Stockholders, no Incentive Stock Option shall be exercisable after the
expiration of ten (10) years from the date it was granted.

        (b) EXERCISE PRICE OF AN INCENTIVE STOCK OPTION. Subject to the
provisions of subsection 5(b) regarding Ten Percent Stockholders, the exercise
price of each Incentive Stock Option shall be not less than one hundred percent
(100%) of the Fair Market Value of the Common Stock subject to the Option on the
date the Option is granted. Notwithstanding the foregoing, an Incentive Stock
Option may be granted with an exercise price lower than that set forth in the
preceding sentence if such Option is granted pursuant to an assumption or
substitution for another option in a manner satisfying the provisions of Section
424(a) of the Code.

        (c) EXERCISE PRICE OF A NONSTATUTORY STOCK OPTION. The exercise price of
each Nonstatutory Stock Option shall be not less than eighty-five percent (85%)
of the Fair Market Value of the Common Stock subject to the Option on the date
the Option is granted. Notwithstanding the foregoing, a Nonstatutory Stock
Option may be granted with an exercise price lower than that set forth in the
preceding sentence if such Option is granted pursuant to an assumption or
substitution for another option in a manner satisfying the provisions of Section
424(a) of the Code.

        (d) CONSIDERATION. The purchase price of Common Stock acquired pursuant
to an Option shall be paid, to the extent permitted by applicable statutes and
regulations, either (i) in cash at the time the Option is exercised or (ii) at
the discretion of the Board at the time of the grant of the Option (or
subsequently in the case of a Nonstatutory Stock Option) (1) by delivery to the
Company of other Common Stock, (2) according to a deferred payment or other
similar arrangement with the Optionholder or (3) in any other form of legal
consideration that may be acceptable to the Board. Unless otherwise specifically
provided in the Option, the purchase price of Common Stock acquired pursuant to
an Option that is paid by delivery to the Company of other Common Stock
acquired, directly or indirectly from the Company, shall be paid only by shares
of the Common Stock of the Company that have been held for more than six (6)
months (or such longer or shorter period of time required to avoid a charge to
earnings for financial accounting purposes). At any time that the Company is
incorporated in Delaware, payment of the Common Stock's "par value," as defined
in the Delaware General Corporation Law, shall not be made by deferred payment.

In the case of any deferred payment arrangement, interest shall be compounded at
least annually and shall be charged at the minimum rate of interest necessary to
avoid the treatment as interest, under any applicable provisions of the Code, of
any amounts other than amounts stated to be interest under the deferred payment
arrangement.

        (e) TRANSFERABILITY OF AN INCENTIVE STOCK OPTION. An Incentive Stock
Option shall not be transferable except by will or by the laws of descent and
distribution and shall be exercisable during the lifetime of the Optionholder
only by the Optionholder. Notwithstanding the foregoing, the Optionholder may,
by delivering written notice to the Company, in a form satisfactory to the
Company, designate a third party who, in the event of the death of the
Optionholder, shall thereafter be entitled to exercise the Option.

        (f) TRANSFERABILITY OF A NONSTATUTORY STOCK OPTION. A Nonstatutory Stock
Option shall be transferable to the extent provided in the Option Agreement. If
the Nonstatutory Stock Option does not provide for transferability, then the
Nonstatutory Stock Option shall not be transferable except by will or by the
laws of descent and distribution and shall be exercisable during the lifetime of
the Optionholder only by the Optionholder. Notwithstanding the foregoing, the
Optionholder may, by delivering written notice to the Company, in a form
satisfactory to the Company, designate a third party who, in the event of the
death of the Optionholder, shall thereafter be entitled to exercise the Option.

        (g) VESTING GENERALLY. The total number of shares of Common Stock
subject to an Option may, but need not, vest and therefore become exercisable in
periodic installments that may, but need not, be equal. The Option may be
subject to such other terms and conditions on the time or times when it may be
exercised (which may be based on performance or other criteria) as the Board may
deem appropriate. The vesting provisions of individual

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Options may vary. The provisions of this subsection 6(g) are subject to any
Option provisions governing the minimum number of shares of Common Stock as to
which an Option may be exercised.

        (h) TERMINATION OF CONTINUOUS SERVICE. In the event an Optionholder's
Continuous Service terminates (other than upon the Optionholder's death or
Disability), the Optionholder may exercise his or her Option (to the extent that
the Optionholder was entitled to exercise such Option as of the date of
termination) but only within such period of time ending on the earlier of (i)
the date three (3) months following the termination of the Optionholder's
Continuous Service (or such longer or shorter period specified in the Option
Agreement), excepting out any Options granted prior to the effective date of the
Amendment and Restatement, or (ii) the expiration of the term of the Option as
set forth in the Option Agreement. If, after termination, the Optionholder does
not exercise his or her Option within the time specified in the Option
Agreement, the Option shall terminate.

        (i) EXTENSION OF TERMINATION DATE. An Optionholder's Option Agreement
may also provide that if the exercise of the Option following the termination of
the Optionholder's Continuous Service (other than upon the Optionholder's death
or Disability) would be prohibited at any time solely because the issuance of
shares of Common Stock would violate the registration requirements under the
Securities Act, then the Option shall terminate on the earlier of (i) the
expiration of the term of the Option set forth in subsection 6(a) or (ii) the
expiration of a period of three (3) months after the termination of the
Optionholder's Continuous Service during which the exercise of the Option would
not be in violation of such registration requirements.

        (j) DISABILITY OF OPTIONHOLDER. In the event that an Optionholder's
Continuous Service terminates as a result of the Optionholder's Disability, the
Optionholder may exercise his or her Option (to the extent that the Optionholder
was entitled to exercise such Option as of the date of termination), but only
within such period of time ending on the earlier of (i) the date twelve (12)
months following such termination (or such longer or shorter period specified in
the Option Agreement), excepting out any Options granted prior to the effective
date of the Amendment and Restatement, or (ii) the expiration of the term of the
Option as set forth in the Option Agreement. If, after termination, the
Optionholder does not exercise his or her Option within the time specified
herein, the Option shall terminate.

        (k) DEATH OF OPTIONHOLDER. In the event (i) an Optionholder's Continuous
Service terminates as a result of the Optionholder's death or (ii) the
Optionholder dies within the period (if any) specified in the Option Agreement
after the termination of the Optionholder's Continuous Service for a reason
other than death, then the Option may be exercised (to the extent the
Optionholder was entitled to exercise such Option as of the date of death) by
the Optionholder's estate, by a person who acquired the right to exercise the
Option by bequest or inheritance or by a person designated to exercise the
Option upon the Optionholder's death pursuant to subsection 6(e) or 6(f), but
only within the period ending on the earlier of (1) the date twelve (12) months
following the date of death (or such longer or shorter period specified in the
Option Agreement), excepting out any Options granted prior to the effective date
of the Amendment and Restatement, or (2) the expiration of the term of such
Option as set forth in the Option Agreement. If, after death, the Option is not
exercised within the time specified herein, the Option shall terminate.

        (l) EARLY EXERCISE. The Option may, but need not, include a provision
whereby the Optionholder may elect at any time before the Optionholder's
Continuous Service terminates to exercise the Option as to any part or all of
the shares of Common Stock subject to the Option prior to the full vesting of
the Option. Any unvested shares of Common Stock so purchased may be subject to a
repurchase option in favor of the Company or to any other restriction the Board
determines to be appropriate. The Company will not exercise its repurchase
option until at least six (6) months (or such longer or shorter period of time
required to avoid a charge to earnings for financial accounting purposes) have
elapsed following exercise of the Option unless the Board otherwise specifically
provides in the Option.

        (m) RE-LOAD OPTIONS.

(i)     Without in any way limiting the authority of the Board to make or not to
        make grants of Options hereunder, the Board shall have the authority
        (but not an obligation) to include as part of any Option Agreement a
        provision entitling the Optionholder to a further Option (a "Re-Load
        Option") in the event the Optionholder exercises the Option evidenced by
        the Option Agreement, in whole or in part, by surrendering other shares
        of Common Stock in accordance with this Plan and the terms and
        conditions of the Option Agreement. Unless otherwise specifically
        provided in the Option, the Optionholder shall not surrender shares of
        Common Stock acquired, directly or indirectly from the Company, unless
        such shares have been held for more than six (6) months (or such longer
        or shorter period of time required to avoid a charge to earnings for
        financial accounting purposes).

(ii)    Any such Re-Load Option shall (1) provide for a number of shares of
        Common Stock equal to the number of shares of Common Stock surrendered
        as part or all of the exercise price of such Option; (2) have an
        expiration

                                       25
<PAGE>   8

date which is the same as the expiration date of the Option the exercise of
which gave rise to such Re-Load Option; and (3) have an exercise price which is
equal to one hundred percent (100%) of the Fair Market Value of the Common Stock
subject to the Re-Load Option on the date of exercise of the original Option.
Notwithstanding the foregoing, a Re-Load Option shall be subject to the same
exercise price and term provisions heretofore described for Options under the
Plan.

(iii)   Any such Re-Load Option may be an Incentive Stock Option or a
        Nonstatutory Stock Option, as the Board may designate at the time of the
        grant of the original Option; provided, however, that the designation of
        any Re-Load Option as an Incentive Stock Option shall be subject to the
        one hundred thousand dollar ($100,000) annual limitation on the
        exercisability of Incentive Stock Options described in subsection 9(d)
        and in Section 422(d) of the Code. There shall be no Re-Load Options on
        a Re-Load Option. Any such Re-Load Option shall be subject to the
        availability of sufficient shares of Common Stock under subsection 4(a)
        and the "Section 162(m) Limitation" on the grants of Options under
        subsection 5(c) and shall be subject to such other terms and conditions
        as the Board may determine which are not inconsistent with the express
        provisions of the Plan regarding the terms of Options.

7. PROVISIONS OF STOCK AWARDS OTHER THAN OPTIONS.

        (a) STOCK BONUS AWARDS. Each stock bonus agreement shall be in such form
and shall contain such terms and conditions as the Board shall deem appropriate.
The terms and conditions of stock bonus agreements may change from time to time,
and the terms and conditions of separate stock bonus agreements need not be
identical, but each stock bonus agreement shall include (through incorporation
of provisions hereof by reference in the agreement or otherwise) the substance
of each of the following provisions:

(i)     CONSIDERATION. A stock bonus may be awarded in consideration for past
        services actually rendered to the Company or an Affiliate for its
        benefit.

(ii)    VESTING. Shares of Common Stock awarded under the stock bonus agreement
        may, but need not, be subject to a share repurchase option in favor of
        the Company in accordance with a vesting schedule to be determined by
        the Board.

(iii)   TERMINATION OF PARTICIPANT'S CONTINUOUS SERVICE. In the event a
        Participant's Continuous Service terminates, the Company may reacquire
        any or all of the shares of Common Stock held by the Participant which
        have not vested as of the date of termination under the terms of the
        stock bonus agreement.

(iv)    TRANSFERABILITY. Rights to acquire shares of Common Stock under the
        stock bonus agreement shall be transferable by the Participant only upon
        such terms and conditions as are set forth in the stock bonus agreement,
        as the Board shall determine in its discretion, so long as Common Stock
        awarded under the stock bonus agreement remains subject to the terms of
        the stock bonus agreement.

        (b) RESTRICTED STOCK AWARDS. Each restricted stock purchase agreement
shall be in such form and shall contain such terms and conditions as the Board
shall deem appropriate. The terms and conditions of the restricted stock
purchase agreements may change from time to time, and the terms and conditions
of separate restricted stock purchase agreements need not be identical, but each
restricted stock purchase agreement shall include (through incorporation of
provisions hereof by reference in the agreement or otherwise) the substance of
each of the following provisions:

(i)     PURCHASE PRICE. The purchase price under each restricted stock purchase
        agreement shall be such amount as the Board shall determine and
        designate in such restricted stock purchase agreement. The purchase
        price shall not be less than eighty-five percent (85%) of the Common
        Stock's Fair Market Value on the date such award is made or at the time
        the purchase is consummated.

(ii)    CONSIDERATION. The purchase price of Common Stock acquired pursuant to
        the restricted stock purchase agreement shall be paid either: (i) in
        cash at the time of purchase; (ii) at the discretion of the Board,
        according to a deferred payment or other similar arrangement with the
        Participant; or (iii) in any other form of legal consideration that may
        be acceptable to the Board in its discretion; provided, however, that at
        any time that the Company is incorporated in Delaware, then payment of
        the Common Stock's "par value," as defined in the Delaware General
        Corporation Law, shall not be made by deferred payment.

                                       26
<PAGE>   9

(iii)   VESTING. Shares of Common Stock acquired under the restricted stock
        purchase agreement may, but need not, be subject to a share repurchase
        option in favor of the Company in accordance with a vesting schedule to
        be determined by the Board.

(iv)    TERMINATION OF PARTICIPANT'S CONTINUOUS SERVICE. In the event a
        Participant's Continuous Service terminates, the Company may repurchase
        or otherwise reacquire any or all of the shares of Common Stock held by
        the Participant which have not vested as of the date of termination
        under the terms of the restricted stock purchase agreement.

(v)     TRANSFERABILITY. Rights to acquire shares of Common Stock under the
        restricted stock purchase agreement shall be transferable by the
        Participant only upon such terms and conditions as are set forth in the
        restricted stock purchase agreement, as the Board shall determine in its
        discretion, so long as Common Stock awarded under the restricted stock
        purchase agreement remains subject to the terms of the restricted stock
        purchase agreement.

8. COVENANTS OF THE COMPANY.

        (a) AVAILABILITY OF SHARES. During the terms of the Stock Awards, the
Company shall keep available at all times the number of shares of Common Stock
required to satisfy such Stock Awards.

        (b) SECURITIES LAW COMPLIANCE. The Company shall seek to obtain from
each regulatory commission or agency having jurisdiction over the Plan such
authority as may be required to grant Stock Awards and to issue and sell shares
of Common Stock upon exercise of the Stock Awards; provided, however, that this
undertaking shall not require the Company to register under the Securities Act
the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any
such Stock Award. If, after reasonable efforts, the Company is unable to obtain
from any such regulatory commission or agency the authority which counsel for
the Company deems necessary for the lawful issuance and sale of Common Stock
under the Plan, the Company shall be relieved from any liability for failure to
issue and sell Common Stock upon exercise of such Stock Awards unless and until
such authority is obtained.

9. USE OF PROCEEDS FROM STOCK.

        Proceeds from the sale of Common Stock pursuant to Stock Awards shall
constitute general funds of the Company.

10. MISCELLANEOUS.

        (a) ACCELERATION OF EXERCISABILITY AND VESTING. The Board shall have the
power to accelerate the time at which a Stock Award may first be exercised or
the time during which a Stock Award or any part thereof will vest in accordance
with the Plan, notwithstanding the provisions in the Stock Award stating the
time at which it may first be exercised or the time during which it will vest.

        (b) STOCKHOLDER RIGHTS. No Participant shall be deemed to be the holder
of, or to have any of the rights of a holder with respect to, any shares of
Common Stock subject to such Stock Award unless and until such Participant has
satisfied all requirements for exercise of the Stock Award pursuant to its
terms.

        (c) NO EMPLOYMENT OR OTHER SERVICE RIGHTS. Nothing in the Plan or any
instrument executed or Stock Award granted pursuant thereto shall confer upon
any Participant any right to continue to serve the Company or an Affiliate in
the capacity in effect at the time the Stock Award was granted or shall affect
the right of the Company or an Affiliate to terminate (i) the employment of an
Employee with or without notice and with or without cause, (ii) the service of a
Consultant pursuant to the terms of such Consultant's agreement with the Company
or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the
Company or an Affiliate, and any applicable provisions of the corporate law of
the state in which the Company or the Affiliate is incorporated, as the case may
be.

        (d) INCENTIVE STOCK OPTION $100,000 LIMITATION. To the extent that the
aggregate Fair Market Value (determined at the time of grant) of Common Stock
with respect to which Incentive Stock Options are exercisable for the first time
by any Optionholder during any calendar year (under all plans of the Company and
its Affiliates) exceeds one hundred thousand dollars ($100,000), the Options or
portions thereof which exceed such limit (according to the order in which they
were granted) shall be treated as Nonstatutory Stock Options.

                                       27
<PAGE>   10

        (e) INVESTMENT ASSURANCES. The Company may require a Participant, as a
condition of exercising or acquiring Common Stock under any Stock Award, (i) to
give written assurances satisfactory to the Company as to the Participant's
knowledge and experience in financial and business matters and/or to employ a
purchaser representative reasonably satisfactory to the Company who is
knowledgeable and experienced in financial and business matters and that he or
she is capable of evaluating, alone or together with the purchaser
representative, the merits and risks of exercising the Stock Award; and (ii) to
give written assurances satisfactory to the Company stating that the Participant
is acquiring Common Stock subject to the Stock Award for the Participant's own
account and not with any present intention of selling or otherwise distributing
the Common Stock. The foregoing requirements, and any assurances given pursuant
to such requirements, shall be inoperative if (1) the issuance of the shares of
Common Stock upon the exercise or acquisition of Common Stock under the Stock
Award has been registered under a then currently effective registration
statement under the Securities Act or (2) as to any particular requirement, a
determination is made by counsel for the Company that such requirement need not
be met in the circumstances under the then applicable securities laws. The
Company may, upon advice of counsel to the Company, place legends on stock
certificates issued under the Plan as such counsel deems necessary or
appropriate in order to comply with applicable securities laws, including, but
not limited to, legends restricting the transfer of the Common Stock.

        (f) WITHHOLDING OBLIGATIONS. To the extent provided by the terms of a
Stock Award Agreement, the Participant may satisfy any federal, state or local
tax withholding obligation relating to the exercise or acquisition of Common
Stock under a Stock Award by any of the following means (in addition to the
Company's right to withhold from any compensation paid to the Participant by the
Company) or by a combination of such means: (i) tendering a cash payment; (ii)
authorizing the Company to withhold shares of Common Stock from the shares of
Common Stock otherwise issuable to the Participant as a result of the exercise
or acquisition of Common Stock under the Stock Award, provided, however, that no
shares of Common Stock are withheld with a value exceeding the minimum amount of
tax required to be withheld by law; or (iii) delivering to the Company owned and
unencumbered shares of Common Stock.

11. ADJUSTMENTS UPON CHANGES IN STOCK.

        (a) CAPITALIZATION ADJUSTMENTS. If any change is made in the Common
Stock subject to the Plan, or subject to any Stock Award, without the receipt of
consideration by the Company (through merger, consolidation, reorganization,
recapitalization, reincorporation, stock dividend, dividend in property other
than cash, stock split, liquidating dividend, combination of shares, exchange of
shares, change in corporate structure or other transaction not involving the
receipt of consideration by the Company), the Plan will be appropriately
adjusted in the class(es) and maximum number of securities subject to the Plan
pursuant to subsection 4(a) and the maximum number of securities subject to
award to any person pursuant to subsection 5(c), and the outstanding Stock
Awards will be appropriately adjusted in the class(es) and number of securities
and price per share of Common Stock subject to such outstanding Stock Awards.
The Board shall make such adjustments, and its determination shall be final,
binding and conclusive. (The conversion of any convertible securities of the
Company shall not be treated as a transaction "without receipt of consideration"
by the Company.)

        (b) DISSOLUTION OR LIQUIDATION. In the event of a dissolution or
liquidation of the Company, then all outstanding Stock Awards shall terminate
immediately prior to such event.

        (c) ASSET SALE, MERGER, CONSOLIDATION OR REVERSE MERGER. In the event of
(i) a sale, lease or other disposition of all or substantially all of the assets
of the Company, (ii) a merger or consolidation in which the Company is not the
surviving corporation or (iii) a reverse merger in which the Company is the
surviving corporation but the shares of Common Stock outstanding immediately
preceding the merger are converted by virtue of the merger into other property,
whether in the form of securities, cash or otherwise (individually, a "Corporate
Transaction"), then any surviving corporation or acquiring corporation shall
assume any Stock Awards outstanding under the Plan or shall substitute similar
stock awards (including an award to acquire the same consideration paid to the
stockholders in the Corporate Transaction for those outstanding under the Plan).
In the event any surviving corporation or acquiring corporation refuses to
assume such Stock Awards or to substitute similar stock awards for those
outstanding under the Plan, then with respect to Stock Awards held by
Participants whose Continuous Service has not terminated, the vesting of such
Stock Awards (and, if applicable, the time during which such Stock Awards may be
exercised) shall be accelerated in full, and the Stock Awards shall terminate if
not exercised (if applicable) at or prior to such Corporate Transaction. This
vesting acceleration only applies to Options granted after the effective date of
the Amendment and Restatement. With respect to any other Stock Awards
outstanding under the Plan, such Stock Awards shall terminate if not exercised
(if applicable) prior to such Corporate Transaction.

        (d) SPECIAL ACCELERATION PROVISIONS. Notwithstanding any other
provisions of this Plan to the contrary, if (i) a Change in Control occurs on or
after March 29, 2001 and (ii) within thirteen (13) months after the

                                       28
<PAGE>   11

date of such Change in Control the Continuous Service of a Participant
terminates due to an involuntary termination (not including death or Disability)
without Cause or due to a Constructive Termination, then the vesting and
exercisability of all Stock Awards held by such Participant shall be accelerated
in full or any reacquisition or repurchase rights held by the Company with
respect to a Stock Award shall lapse in full, as appropriate; provided, however,
that Stock Award(s) may at the discretion of the Board provide alternative
provisions more favorable to the recipient regarding potential acceleration of
the vesting and exercisability thereof (or lapse of reacquisition or repurchase
rights held by the Company with respect to Stock Awards) in the event of a
Change of Control, and if so then such alternative provisions shall govern and
this paragraph shall not apply to such Stock Award(s).

        (e) PARACHUTE PAYMENTS. In the event that the acceleration of the
vesting and exercisability of the Stock Awards and/or the lapse of reacquisition
or repurchase rights with respect to Stock Awards provided for in subsection
11(d) and benefits otherwise payable to a Participant (i) constitute "parachute
payments" within the meaning of Section 280G of the Code, or any comparable
successor provisions, and (ii) but for this subsection would be subject to the
excise tax imposed by Section 4999 of the Code, or any comparable successor
provisions (the "Excise Tax"), then such Participant's benefits hereunder shall
be either

                (i)     provided to such Participant in full, or

                (ii)    provided to such Participant as to such lesser extent
                        which would result in no portion of such benefits being
                        subject to the Excise Tax,

whichever of the foregoing amounts, when taking into account applicable federal,
state, local and foreign income and employment taxes, the Excise Tax, and any
other applicable taxes, results in the receipt by such Participant, on an
after-tax basis, of the greatest amount of benefits, notwithstanding that all or
some portion of such benefits may be taxable under the Excise Tax. Unless the
Company and such Participant otherwise agree in writing, any determination
required under this subsection shall be made in writing in good faith by the
Accountants. In the event of a reduction of benefits hereunder, the Participant
shall be given the choice of which benefits to reduce. For purposes of making
the calculations required by this subsection, the Accountants may make
reasonable assumptions and approximations concerning applicable taxes and may
rely on reasonable, good faith interpretations concerning the application of the
Code, and other applicable legal authority. The Company and the Participant
shall furnish to the Accountants such information and documents as the
Accountants may reasonably request in order to make a determination under this
subsection. The Company shall bear all costs the Accountants may reasonably
incur in connection with any calculations contemplated by this subsection.

If, notwithstanding any reduction described in this subsection, the IRS
determines that the Participant is liable for the Excise Tax as a result of the
receipt of the payment of benefits as described above, then the Participant
shall be obligated to pay back to the Company, within thirty (30) days after a
final IRS determination or in the event that the Participant challenges the
final IRS determination, a final judicial determination, a portion of the
payment equal to the "Repayment Amount." The Repayment Amount with respect to
the payment of benefits shall be the smallest such amount, if any, as shall be
required to be paid to the Company so that the Participant's net after-tax
proceeds with respect to any payment of benefits (after taking into account the
payment of the Excise Tax and all other applicable taxes imposed on such
payment) shall be maximized. The Repayment Amount with respect to the payment of
benefits shall be zero if a Repayment Amount of more than zero would not result
in the Participant's net after-tax proceeds with respect to the payment of such
benefits being maximized. If the Excise Tax is not eliminated pursuant to this
paragraph, the Participant shall pay the Excise Tax.

Notwithstanding any other provision of this subsection 11(e), if (i) there is a
reduction in the payment of benefits as described in this subsection, (ii) the
IRS later determines that the Participant is liable for the Excise Tax, the
payment of which would result in the maximization of the Participant's net
after-tax proceeds (calculated as if the Participant's benefits had not
previously been reduced), and (iii) the Participant pays the Excise Tax, then
the Company shall pay to the Participant those benefits which were reduced
pursuant to this subsection contemporaneously or as soon as administratively
possible after the Participant pays the Excise Tax so that the Participant's net
after-tax proceeds with respect to the payment of benefits is maximized.

If the Participant either (i) brings any action to enforce rights pursuant to
this subsection 11(e), or (ii) defend any legal challenge to his or her rights
hereunder, the Participant shall be entitled to recover attorneys' fees and
costs incurred in connection with such action, regardless of the outcome of such
action; provided, however, that in the event such action is commenced by the
Participant, the court finds the claim was brought in good faith.

12. AMENDMENT OF THE PLAN AND STOCK AWARDS.

                                       29
<PAGE>   12

        (a) AMENDMENT OF PLAN. The Board at any time, and from time to time, may
amend the Plan. However, except as provided in Section 11 relating to
adjustments upon changes in Common Stock, no amendment shall be effective unless
approved by the stockholders of the Company to the extent stockholder approval
is necessary to satisfy the requirements of Section 422 of the Code, Rule 16b-3
or any Nasdaq or securities exchange listing requirements.

        (b) STOCKHOLDER APPROVAL. The Board may, in its sole discretion, submit
any other amendment to the Plan for stockholder approval, including, but not
limited to, amendments to the Plan intended to satisfy the requirements of
Section 162(m) of the Code and the regulations thereunder regarding the
exclusion of performance-based compensation from the limit on corporate
deductibility of compensation paid to certain executive officers.

        (c) CONTEMPLATED AMENDMENTS. It is expressly contemplated that the Board
may amend the Plan in any respect the Board deems necessary or advisable to
provide eligible Employees with the maximum benefits provided or to be provided
under the provisions of the Code and the regulations promulgated thereunder
relating to Incentive Stock Options and/or to bring the Plan and/or Incentive
Stock Options granted under it into compliance therewith.

        (d) NO IMPAIRMENT OF RIGHTS. Rights under any Stock Award granted before
amendment of the Plan shall not be impaired by any amendment of the Plan unless
(i) the Company requests the consent of the Participant and (ii) the Participant
consents in writing.

        (e) AMENDMENT OF STOCK AWARDS. The Board at any time, and from time to
time, may amend the terms of any one or more Stock Awards; provided, however,
that the rights under any Stock Award shall not be impaired by any such
amendment unless (i) the Company requests the consent of the Participant and
(ii) the Participant consents in writing.

13. TERMINATION OR SUSPENSION OF THE PLAN.

        (a) PLAN TERM. The Board may suspend or terminate the Plan at any time.
Unless sooner terminated, the Plan shall terminate on the day before the tenth
(10th) anniversary of the date the Plan is adopted by the Board or approved by
the stockholders of the Company, whichever is earlier. No Stock Awards may be
granted under the Plan while the Plan is suspended or after it is terminated.

        (b) NO IMPAIRMENT OF RIGHTS. Suspension or termination of the Plan shall
not impair rights and obligations under any Stock Award granted while the Plan
is in effect except with the written consent of the Participant.

14. EFFECTIVE DATE OF PLAN.

The Plan shall become effective as determined by the Board, but no Stock Award
shall be exercised (or, in the case of a stock bonus, shall be granted) unless
and until the Plan has been approved by the stockholders of the Company, which
approval shall be within twelve (12) months before or after the date the Plan is
adopted by the Board.

15. CHOICE OF LAW.

The law of the State of California shall govern all questions concerning the
construction, validity and interpretation of this Plan, without regard to such
state's conflict of laws rules.

                                       30<PAGE>   1

                    MODIFICATION TO LOAN & SECURITY AGREEMENT

     This Modification to that certain Amended and Restated Loan and Security
Agreement (this "Modification") is entered into by and between PHARMCHEM, INC.,
a Delaware corporation ("Borrower") and COMERICA BANK-CALIFORNIA ("Bank") as of
this 7th day of September, 2000.

                                    RECITALS

     A.   Bank and PharmChem Laboratories, Inc. ("Laboratories"),
predecessor-in-interest to Borrower did previously enter into that certain
Amended And Restated Loan and Security Agreement dated as of May 15, 2000
(originally dated as of May 25, 2000 and revised thereafter to be effective as
of the date set forth above) (the "Agreement").

     B.   Thereafter, pursuant to that certain Assumption Agreement made as of
July 27, 2000 between Borrower and Bank, Borrower, as Assignee, assumed all of
the Obligations of Laboratories under the Loan Documents.

     C.   Borrower has requested and Bank has agreed to provide additional
financing to Borrower and to modify the terms of the Loan Documents all as more
specifically set forth below.

     NOW, THEREFORE, for valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, the parties hereto agree as follows:

                                    AGREEMENT

     1.   Incorporation by Reference. The foregoing recitals of facts and
understandings of the parties, and the Agreement as modified hereby, are
incorporated herein by this reference:

     2.   New Loan. Upon the effectiveness of this Modification, Bank shall make
a new loan to Borrower in the principal amount of One Million, Six Hundred
Seventy Three Thousand Eight Hundred Dollars ($1,673,800), the proceeds of which
shall be used by Borrower to repay the principal outstanding under the Term Loan
and for the acquisition of specific equipment. The new loan shall be evidenced
by a Variable Rate-Installment Note which will mature on April 14, 2004 and
which shall be repaid in accordance with the terms set forth therein (the "New
Term Note"). All references to the Term Loan in the Agreement, shall mean the
loan as evidenced by the New Term Note.

     3.   Modification of Agreement.

          a.   Section 1. Definitions and Construction is hereby modified to
define Term Loan, as follows:

               "Term Loan" means the term loan in the amount of One Million Six
          Hundred Seventy Three Thousand, Eight Hundred Dollars ($1,673,800)
          pursuant to the provisions of Section 2.1.2"

          b.   Section 2.1.2 Term Loan is hereby deleted in its entirety, and
replaced with the following:

               "2.1.2 Term Loan

               Bank shall make a Term Loan to Borrower in the aggregate amount
          of One Million Six Hundred Seventy Three Thousand Eight Hundred
          Dollars ($1,673,800). Effective as of the date of the funding thereof,
          the Term Loan shall bear interest at a per annum rate equal to the
          Prime Rate plus one-half of one percent (0.50%). The Term Loan shall
          be payable in monthly installments of principal in the amount of
          Thirty Eight Thousand, Forty Dollars and 91/100 ($38,040.91) each,
          plus all accrued interest, beginning on October 14, 2000 and
          continuing on the same day of each month thereafter through the Term
          Maturity Date, at which time all amounts due under this Section 2.1.2
          and any other amounts owing under this Agreement shall be immediately
          due and payable."

     4.   Conditions to Effectiveness. This Modification shall be effective when
the following conditions have been satisfied:

          (a)  There shall have been delivered to Bank, each of the following,
duly executed and in form satisfactory to Bank:

               (i)   this Modification;

               (ii)  the New Note;

<PAGE>   2

               (iii) a Borrower's Authorization;

               (iv)  an Automatic Loan Payment Authorization;

               (v)   a Borrower's Telephone and Facsimile Authorization;

               (vi)  an Agreement to Furnish Insurance (naming Borrower as the
                     "Named Insured" and Bank as "Loss Payee"), and

               (vii) any other documents or instruments as may be required by
                     Bank to effectuate this Modification.

     5.   Legal Effect. Except as specifically set forth in this Modification
and the New Note, all of the terms and conditions of the Agreement and the Loan
Documents shall remain in full force and effect. All capitalized terms not
otherwise defined herein, shall have the meaning given to them in the Agreement.

     6.   Integration. This is an integrated Modification and supersedes all
prior negotiations and agreements regarding the subject matter hereof. All
amendments hereto must be in writing and signed by the parties.

     7.   Counterparts. This Modification may be executed in any number of
counterparts and by different parties on separate counterparts, each of which,
when executed and delivered, shall be deemed to be an original, and all of
which, when taken together, shall constitute but one and the same Modification.

     IN WITNESS WHEREOF, the parties have agreed as of the date first set forth
above.

"BORROWER"                              "BANK"

PHARMCHEM, INC.                         COMERICA BANK-CALIFORNIA

By /s/ David A. Lattanzio               By /s/ James L. Weber
  ------------------------------------    --------------------------------------
  David A. Lattanzio                      James L. Weber

Title: Vice President & CFO             Title: Vice President

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