Document:

EX-10.21(e)

 Exhibit 10.21(e) 

CONFIDENTIAL 
 CERTAIN CONFIDENTIAL
INFORMATION IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS BOTH (I) NOT MATERIAL AND (II) WOULD BE COMPETITIVELY HARMFUL IF PUBLICLY DISCLOSED 

AMENDMENT NO. 4 TO 

EXCLUSIVE START-UP LICENSE AGREEMENT BETWEEN 

SANA BIOTECHNOLOGY, INC. AND UNIVERSITY OF WASHINGTON 

THIS AMENDMENT NO. 4 (“Amendment No. 4”), with an effective date of January 21, 2021 (“Amendment
No. 4 Effective Date”), is entered into by and between Sana Biotechnology, Inc. (“Company”) and University of Washington (“University”). 

WHEREAS, Cytocardia, Inc. (“Cytocardia”) (a subsidiary of and predecessor in interest under this Agreement to COMPANY) and UNIVERSITY entered
into an Exclusive Start-Up License Agreement for [***], dated October 9, 2018 (the “Original Agreement”), and amended on November 6, 2019 (“Amendment
No. 1”), July 16, 2020 (“Amendment No. 2”), and November 11, 2020 (“Assignment of License Agreement”); and 

WHEREAS, Cytocardia assigned the Original Agreement, as amended by Amendment No. 1 and Amendment No. 2, to COMPANY via the Assignment of License
Agreement (“Amendment No. 3”), dated November 11, 2020; and 
 WHEREAS, by this Amendment No. 4, the Parties wish to amend the
Original Agreement, Amendment No. 1, Amendment No. 2 and Amendment No. 3, as set forth in Section 2 herein; and 
 WHEREAS, the Parties
desire that all other terms and conditions of the Original Agreement, Amendment No. 1, Amendment No. 2, and Amendment No. 3 remain in full force and effect; 

NOW, THEREFORE, COMPANY and UNIVERSITY hereby agree as follows: 

1. Capitalized terms used in this Amendment No. 4 shall have the same meaning as those in the Original Agreement, Amendment No. 1, Amendment
No. 2, and Amendment No. 3 as the case may be, unless specifically defined otherwise in this Amendment No. 4. All article and section references shall refer to the corresponding Article and Section in the Original Agreement as amended
by Amendment No. 1, Amendment No. 2, and Amendment No. 3. All references to the “Agreement” in the Original Agreement, Amendment No. 1, Amendment No. 2, Amendment No. 3, and this Amendment No. 4 shall
mean the Original Agreement as amended hereby. 
 2. Amendments 

2.1 Section 2.1; Patent License. Section 2.1 (Patent License) of the Original Agreement is hereby amended and restated in its
entirety as follows: 
 “2.1 Patent License. University hereby grants to Company an exclusive (subject only to any rights of the
government described in Section 2.6 “The United States Government’s Rights” and to rights of University and Cambridge, described in Section 3 “Rights of University, Limitations”) license under the Licensed Patents
to make, have made on Company’s behalf, use, offer to sell, sell, offer to lease or lease, import, or otherwise offer to dispose of Licensed Products in the Territory in the Field of Use. Unless otherwise terminated under Section 9
(Termination), the term of this patent license will begin on the Effective Date and will continue 

 
until all Valid Claims expire or are held invalid or unenforceable by a court of competent jurisdiction from which no appeal can be taken. For the avoidance of doubt and notwithstanding anything
in this Agreement to the contrary, the above grant of rights, and any other rights granted, obligations of University, or representations or warranties made by University, for Licensed Patents of UW reference number [***] are for University’s
rights in such Licensed Patents only and not for any rights which may be owned by [***].” 
 2.2 Exhibit A, Section A1.1 (Licensed
Patents). After the end of the table listing Licensed Patents, Group 1 in Exhibit A, Section A1.1 of the Original Agreement, the following is hereby inserted: 

[***] 
 3. Miscellaneous. 

3.1 Amendment Fee. Company will pay University a one-time fee of [***] ($[***]) in
consideration for the additional rights granted to Company under this Third Amendment, payable within thirty (30) days of the Amendment No. 4 Effective Date. 

3.2 Effect and Interpretation. This Amendment No. 3 shall be effective for all purposes as of the Amendment No. 4 Effective
Date. To the extent that there are any inconsistencies between this Amendment No. 4 and the Original Agreement as amended by Amendment No. 1, Amendment No. 2, and Amendment No. 3, the terms of this Amendment No. 4 shall
supersede those set forth in the Original Agreement, Amendment No. 1, Amendment No. 2, and Amendment No. 3. Except as otherwise expressly modified by this Amendment No. 4, the Original Agreement as amended by Amendment
No. 1, Amendment No. 2, and Amendment No. 3 shall remain in full force and effect in accordance with its terms. As of the Amendment No. 4 Effective Date, the term “Agreement” (as used herein and in the Original
Agreement, Amendment No. 1, Amendment No. 2, and Amendment No. 3) shall mean the Original Agreement, Amendment No. 1, Amendment No. 2, and Amendment No. 3 as amended by this Amendment No. 4. 

3.3 Counterparts. This Amendment No. 4 may be executed in one or more counterparts by original, facsimile or PDF signature, each
of which shall be deemed to be an original, but all of which together shall constitute one and the same instrument. 
 IN WITNESS WHEREOF, COMPANY and
UNIVERSITY have caused this Amendment No. 4 to be executed by their respective duly authorized representatives as of the Amendment No. 4 Effective Date. 
  

									
	SANA BIOTECHNOLOGY, INC.	 		 	UNIVERSITY OF WASHINGTON
					
	By:	 	 /s/ Chris Pritchard
	 		 	By:	 	 /s/ Fiona Wills

					
	Name:	 	Chris Pritchard	 		 	Name:	 	Fiona Wills
					
	Title:	 	VP, Business Development	 		 	Title:	 	Associate Vice Provost
					
	Date:	 	 January 21, 2021
	 		 	Date:	 	 January 21, 2021

  

					
	Amendment 4 to the Exclusive License between Sana Biotechnology, Inc. and University of Washington
	UW CoMotion #37004A	  	Page 2 of 2Bio-Carbon-Based
Fertilizer (“BCBF”) 

Purchase
and Sales Agreement 

 

Party
A: SCQC Agricultural Co. Limited

 

Party
B: Pingchang Lingfeng Agricultural Development Co., Ltd.

 

In
accordance with “Contract Law of the People's Republic of China” and relevant laws and regulations, both parties have
reached the following terms and conditions regarding sale and purchase of BCBF, after mutual agreement.

 

Article
1: Cooperation method

Party
A purchases the BCBF produced by Party B and promotes the fertilizer to become the only official fertilizer designated by Party
A.

 

Article
2: Product Standards

2.1
The standards (including quality requirements) of the products are implemented in accordance with the National implementation
standards:

 

Organic
fertilizer NY525, Bio-Charcoal Based Fertilizer NY/T3401, and related standards: Q/511923LFNY 001-2020.

 

2.2
Quantity of products: To be calculated in accordance cumulative aggregate basis, the level of acceptable difference in quantity
to be delivered and actual delivered by positive or negative 2%.

 

Article
3: Production quantity

The
cooperation between the two parties is order-based production. The total number of orders is 612.49 tons. Party B shall
complete all production of fertilizer within 30 days after signing this contract.

 

Article
4: Prices and payment methods

4.1
Unit price: RMB1,900 per ton, total price RMB1,163,746

 

4.2
The price is tax-inclusive, but not limited to material cost, loading & unloading charge, labour charge, etc. Transportation
cost will be borne by Party A. This price is fixed, and still remains unchanged when there is any market price fluctuation.

    	 

    	 

    

4.3
After signing this contract, Party A will pay RMB483,746 by March 30, 2020 as down payment. RMB600,000 will be paid by April 13,
2020 as second instalment and the balance will be settled by April 15, 2020. When all payments are well received, Party B will
complete the production within the aforesaid deadline. Party B should delivery the products to the designated place at designated
date according to Party A instruction.

 

4.4
Party B’s banking details to receive:

Account
name: redacted

Account
number: redacted

Bank:
redacted 

 

Article
5: Packaging quality

In
order to keep the quality of bio-carbon-based organic fertilizer, Party B have to provide with high-end package for fertilizer
to be displayed in particle form. The package must be non-smelly.

 

Article
6: Weight loss control and transfer of goods ownership

6.1
As loss of water weight is common for organic fertilizing products, Party B should take precautionary measures to guarantee the
products weight loss will be limited to not more than 2%, during 3 to 6 months from the time the fertilizer is delivered.

 

6.2
Goods ownership is transferred once the payment is settled. However, Party B will bear the risk of lost and damage during Party
B’s transportation.

 

Article
7: Delivery time, freight burden and return and exchange

Products
are temporarily kept in Party B’s warehouse when the production is completed. Delivery of products will be arranged by Party
B within 3 days from Party A’s request. Party A will bear transportation charge. In case of return and/or exchange, additional
charges to be borne will be negotiated by both parties.

 

    	 

    	 

    

Article
8: Liability for breach of contract

Once
this contract is mutually signed, both parties should strictly follow the terms and conditions as per listed and perform each
party’s obligations accordingly. In case of breaching contract, breaching party will have to pay 30% of the total sum of
this contract as compensation, and also have to bear all investigation charge, litigation costs, lawyer fee, travelling expense,
etc., any reasonable charges and expenses come along.

 

Article
9: Force Majeure

9.1
In the event of force majeure, such as: war, fire, typhoon, earthquake and factors that cannot be predicted and controlled within
the normal circumstances.

9.2
If one party is unable to perform part or all of the obligations under this contract due to force majeure, the party affected
by the force majeure shall not be liable for breach of the contract; but the party shall notify the other party within 5 working
days after the force majeure occurs, and issue a proof that the force majeure has occurred and the corresponding consequences,
otherwise the party shall bear the corresponding liability for breach of contract.

 

Article
10: Dispute Resolution

The
parties shall attempt to resolve any dispute arising out of or relating to this contract through negotiations. If the matter is
not resolvable by negotiation, the parties shall attempt to resolve the dispute through the People's Court, where Party A is located.

 

Article
11: Confidentiality 

Both
parties agree (including its employees, consultants, etc.) to keep confidential on commercial secrets during the effect of this
contract. Without one party’s written consent, counterparty shall not disclose, leak the matters of this agreement, any
incidental matters and other confidential information to third party, or shall not use for purposes other than to complete this
contract. Otherwise, the party shall compensate the counterparty for all losses caused thereby.

 

    	 

    	 

    

Article
12: Supplementary Terms

12.1
All the terms of this agreement are only valid for both parties to the contract and shall not be used for other purposes.

12.2
Matters not covered in this contract shall be dealt with separately through negotiation between the parties.

12.3
This contract will become effective from the date when both parties sign with company seal.

12.4
The annex to the contract is also legal binding.

12.5
This contract is made in four copies. Party A and Party B each hold two copies, and each copy is legal binding.

=====================================================================

 

Party
A

/s/
SCQC Agricultural Co. Limited

Date:
June 12 2020

 

Party
B

/s/Pingchang
Lingfeng

Agricultural
Development Co., Ltd

Date:
June 12 2020

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