Document:

Exhibit 10.15  

[EPOCRATES LOGO]

October 18,
2006 

Richard
H. Van Hoesen 

Dear
Rick, 

        On
behalf of Epocrates, Inc. ("Epocrates" or the "Company"), I am pleased to offer you the position of Chief Financial Officer, and Senior Vice President of Finance. The terms and
conditions of your new position and employment relationship with the Company are as set forth below: 

1.    Position and Work Schedule; Initial Part-Time Employment Arrangement.

        a.     You
will become the Chief Financial Officer, and Senior Vice President of Finance. You will report directly to the Chairman and CEO and work out of the Company's
corporate headquarters in San Mateo, California. After an initial period of part-time employment described below, your position will be full-time. 

        b.     You
agree to the best of your ability and experience that you will at all times conscientiously perform all of the duties and obligations required of you to the
satisfaction of the Company. During the term of your full-time employment, you further agree that you will devote your full business time and attention to the business of the Company, the
Company will be entitled to all of the benefits and profits arising from or incident to all such work services and advice, you will not render commercial or professional services of any nature to any
person or organization, or engage in self-employment, whether or not for compensation, without the prior written consent of the Company, and you will not directly or indirectly engage or
participate in any business that is competitive in any manner with the business of the Company. Nothing in this letter agreement will prevent you from accepting speaking or presentation engagements in
exchange for honoraria or from serving on boards of charitable organizations, o owning no more than one percent (1%) of the outstanding equity securities of a corporation whose stock is listed on a
national stock exchange. 

        c.     As
discussed, initially you will work as a part-time employee of the Company, which will transition to a full-time position on the schedule
discussed below. As a part-time employee, you will be expected to provide services within a time commitment averaging approximately twenty to thirty percent (20-30%) of that of
a full-time professional employee. 

2.    Start Date.    Subject to fulfillment of any conditions imposed by this letter
agreement, you will commence your part-time employment with the Company on October 19, 2006 (the "Start Date"), and your full-time position will become effective as of
November 13, 2006. 

3.    Proof of Right to Work.    For purposes of federal immigration law, you will
be required to provide to the Company documentary proof of your identity and eligibility for employment in the United States. This offer of employment is contingent upon such satisfactory proof. 

4.    Compensation.

        a.     Base Salary.    During your part-time employment period, you will receive a
weekly base salary of $1,500 paid on the Company's regular payroll schedule. Once you commence full-time employment, your base salary will be paid in semi-monthly installments
of $10,416.67 pursuant to the Company's regular payroll policy, which equates to an annual base salary of $250,000. Because your position is classified as exempt, you will not be eligible for overtime
premiums or additional compensation at any time. Your base salary may be reviewed annually as part of the Company's normal salary review process. Any changes to your base salary are at the Company's
sole discretion. 

        b.     Bonus Compensation.    You will be eligible to participate in the 2006 Executive Bonus
Plan (the "Bonus Plan"), pursuant to the terms and conditions of the Bonus Plan. Your target bonus will be 35% of your 2006 earnings, and the actual bonus paid will be based upon the Company's
performance 

(as
determined by the Company) against the Bonus Plan. You must remain employed during the entire year to earn and be eligible to receive a bonus under the Bonus Plan. Whether a bonus has been earned
under the Bonus Plan, and the amount of any earned bonus, will be determined by the Company and approved by the Board of Directors within its sole discretion. 

5.    Stock Option.    In connection with the commencement of your
full-time employment, the Company will recommend that the Board of Directors (the "Board") grant you an option to purchase three hundred fifty thousand, nine hundred seventy eight
(350,978) shares of the Company's Common Stock ("Shares") under the Company's Stock Plan (the "Plan") with an exercise price equal to the fair market value on the date of the grant as determined by
the Board (the "Option"), The Option will be subject to the terms of the Plan and your individual Stock Option Agreement with the Company, which shall include the following vesting schedule for the
Shares: 1/4th of the Shares shall vest on the first annual anniversary of the Start Date, and 1/48th of the Shares shall vest monthly thereafter over the next three years. Vesting will,
of course, depend on your continued service with the Company, as defined by the Plan. The Option will be an incentive stock option to the maximum extent allowed by the tax code. 

Notwithstanding
the foregoing vesting schedule, the Shares (and the shares subject to any future option grants) will be subject to the Acceleration (defined below) if the Company consummates a change
of control merger or acquisition transaction (not including any initial public offering of the Company's securities) whereby the holders of the Company's outstanding voting stock immediately prior to
such transaction own, immediately after the closing of the qualifying transaction, securities representing less than fifty percent (50%) of the voting stock of the Company or other entity surviving
such transaction, and your employment is either (i) terminated by the Company or a successor entity without Cause (as defined in Paragraph 11 of this letter) within twelve
(12) months after such transaction, or (ii) terminated by you due to your resignation for Good Reason (defined below) within twelve (12) months after such transaction, if the Good
Reason upon which your resignation is based occurs subsequent to and as a result of such transaction. Good Reason shall mean any of the following which occurs without your written consent:
(a) a relocation of your assigned office more than thirty-five (35) miles; (b) a material decrease in your base salary (except for salary decreases generally
applicable to the Company's other executive employees); or (c) a material reduction in the scope of your duties or responsibilities. In order to be eligible to receive the Acceleration, you
must first sign, date, and deliver to the Company a general release of all known and unknown claims in the form provided to you by the Company and allow it to become effective. For purposes of this
letter, the "Acceleration" shall mean additional vesting of the Shares (and the shares subject to any future option grants) such that all unvested
Shares subject to the Option (and the shares subject to any future option grants) shall become fully vested and immediately exercisable. 

6.    Benefits.    Once you commence full-time employment, and subject
to the terms, conditions and limitations of the benefit plans, you will be eligible to participate in the Company's standard employee benefits currently consisting of short/long term disability,
medical, dental, and vision
insurance benefits. Eligibility for participation in these group benefits will become effective the first of the month following your commencement of full-time employment. Subject to the
terms of the Company's vacation policy and practice, once you commence full-time employment you will accrue vacation at the annual rate of fifteen (15) days during your first twelve
(12) months of employment, and at the rate of twenty (20) days per year thereafter. Further details about benefits are available for your review. You will not be eligible to participate
in the Company's standard employee benefits during your part-time employment period, and you will not accrue vacation or other paid time off. Epocrates may modify compensation and benefits
from time to time at its discretion. 

7.    Employee 401(k) Plan.    You will be eligible to participate in Epocrates'
401(K) plan in accordance with the terms of the 401(k) plan. Employees who choose to participate will have pre-tax dollars deposited into their 401(K) account and the money will be
directed to specified investment options. Epocrates does not match funds or make contributions. 

8.    Confidential Information and Invention Assignment Agreement.    Your
acceptance of this offer and commencement of employment with the Company is contingent upon the execution, and delivery to an officer of the Company, of the Company's Confidential Information and
Invention Assignment Agreement (the "Confidentiality Agreement"), a copy of which is enclosed for your review and execution, prior to or on your Start Date. You are also required to abide by the
Confidentiality Agreement as a condition of your employment. In your work for the Company, you will be expected not to use or disclose any confidential information, including trade secrets, of any
former employer or other person to whom you have an obligation of confidentiality. Rather, you may use only that information generally known and used by persons with training and experience comparable
to your own, which is common knowledge in the industry or otherwise legally in the public domain, or which is otherwise provided or developed by the Company, or developed by you on behalf of the
Company. You agree that you will not bring onto Company premises any unpublished documents or property belonging to any former employer or other person to whom you have an obligation of
confidentiality. You represent further that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company. 

9.    Company Policies.    As a condition of your employment, you will be expected
to abide by the Company policies and procedures, and acknowledge in writing that you have read and will comply with the Company's Employee Handbook. 

10.    At-Will Employment.    At all times, your employment with the
Company will be on an "at will" basis, meaning that either you or the Company may terminate your employment at any time, with or without cause, and with or without advance notice. Your employment
at-will status can only be modified in a written agreement signed by you and by an officer of the Company. 

11.    Severance:    In the event that, after you commence full-time
employment, either the Company terminates your employment without Cause, or you resign your employment for Good Reason (as defined in Section 5), and if you first sign, date, and deliver to the
Company a general release of all known and unknown claims in the form provided to you by the Company and allow this release to become effective, then you will receive, as your sole severance benefits:
(i) severance pay equal to nine (9) months of your base salary in effect as of the termination date, less required deductions and withholdings, paid in the form of salary continuation on
the Company's standard payroll dates (beginning with the first payroll date following the effective date of the required release of claims); (ii) payment of annual bonus, if any, at "plan,"
such payment to be pro-rated based on the employment termination date and subject to required deductions and withholdings; and (iii) provided that you timely elect continued group
health insurance coverage through COBRA, the Company will pay your COBRA premiums sufficient to continue your group health insurance coverage at the same level in effect as of your termination date
for nine (9) months after your termination or until you become eligible for group health insurance coverage through a new employer, whichever occurs first. For purposes of this letter,
"Cause" means any of the following conduct by you: (i) embezzlement, misappropriation of corporate funds, or other material acts of dishonesty;
commission or conviction of any felony, or of any misdemeanor involving moral turpitude, or entry of a plea of guilty or nolo contendere to any felony or misdemeanor; (iii) engagement in any
activity that you know or should know could materially harm the business or reputation of the Company; (iv) material failure to adhere to the Company's corporate codes, policies or procedures
as in effect from time to time; (v) material violation of any statutory, contractual, or common law duty or obligation to the Company, including, without limitation, the duty of loyalty;
(vi) material breach of the Confidentiality Agreement; or (vii) repeated failure, in the reasonable judgment of the Board, to substantially perform your assigned duties or
responsibilities after written notice from the Board describing the failure(s) in reasonable detail and your failure to cure such failure(s) within thirty (30) days of receiving such written
notice. 

12.    Complete Agreement.    This letter, together with your Confidentiality
Agreement, forms the complete and exclusive statement of your employment agreement with the Company. The terms in this letter supersede any other agreements or promises made to you by anyone, whether
oral or written. Other than those changes expressly reserved to the Company's discretion in this letter, this letter 

agreement
cannot be changed except in a written agreement signed by you and a duly authorized officer of the Company. 

        We
are all delighted to be able to extend you this offer and look forward to working with you. To indicate your acceptance of the Company's offer, please sign and date this letter in the
space provided below and return it to me, along with a signed and dated copy of the Confidentiality Agreement. 

        This
offer is valid until October 20, 2006. 

Very
truly yours,

Epocrates, Inc.

/s/
JOHN S. OWENS 

John
S. Owens 

Vice
President

Human Resources 

UNDERSTOOD, ACCEPTED AND AGREED:  

Richard H. Van Hoesen 

	/s/ RICHARD H. VAN HOESEN
 Signature	 	 
	10/19/06
 Date	 	 
	10/19/06
 Start Date	 	 

   [Epocrates Letterhead]

March 11,
2008 

Richard
H. Van Hoesen
 [Address]

	Re:
	 Modification of Employment Terms

Dear
Rick: 

As
we have discussed, this letter agreement confirms an amendment (the "Amendment") to the terms of your employment offer letter with
Epocrates, Inc. (the "Company") dated October 18, 2006 (the "Offer Letter"). The Amendment
will become effective only as of the effective date of the initial public offering of the Company's common stock (the "IPO"), and if the IPO does not
occur, this Amendment will not become effective. 

The
Amendment is as follows:

        1.     The following language in quotations shall be deleted from the eighth, ninth and tenth lines of Section 11 of the Offer
Letter: "paid in
the form of salary continuation on the Company's standard payroll dates (beginning with the first payroll date following the effective date of the required release of claims)." 

         2.     The following will become Section 13 of the Offer Letter. 

        13.    Parachute Payments.    In the event that the benefits provided
for in this letter agreement or otherwise payable to you ("Payment") would constitute "parachute payments" within the meaning of Section 280G of
the Internal Revenue Code of 1986, as amended (the "Code") and, but for this sentence, would be subject to the excise tax imposed by Section 4999
of the Code (the "Excise Tax"), then such Payment shall be equal to the Reduced Amount. The "Reduced
Amount" shall be either (i) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax, or (ii) the largest
portion, up to and including the total, of the Payment, whichever of the foregoing amounts, after taking into account all applicable federal, state and local employment taxes, income taxes and the
Excise Tax (all computed at the highest applicable marginal rate), results in the receipt by you, on an after-tax basis, of the greater amount of the Payment, notwithstanding that all or
some portion of the Payment may be subject to the Excise Tax. Unless the Company and you otherwise agree in writing, the determination of your Excise Tax liability shall be made in writing by the
accounting firm engaged by the Company for general audit purposes as of the day prior to the effective date of the Change of Control (the
"Accountants"). If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the
Change of Control, the Company shall appoint a nationally recognized accounting firm to make the determinations required hereunder. For purposes of making the calculations required by this
Section 13, the Accountants may make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good faith interpretations concerning the application of
Sections 280G and 4999 of the Code. Any good faith determinations of the Accountants made hereunder shall be final, binding, and conclusive upon the Company and you. The Company and you shall
furnish to the Accountants such information and documents as the Accountants may reasonably request in order to make a determination under this Section. The Company shall bear all costs the
Accountants may reasonably incur in connection with any calculations contemplated by this Section 13. To the extent that any elimination in or reduction of payments or benefits is made under
this Section 13, the determination as to the order in which payments and benefits shall be reduced shall be made by you (subject, however, to the Company's approval if made on or after the date
on which the event that triggers the payments or benefits occurs). 

1

 

         3.     The following will become Section 14 of the Offer Letter. 

        14.    Form and Timing of Severance Payments.    The nine
(9) months of base salary severance pay provided for in Section 11 shall be paid in the form of salary continuation on the Company's standard payroll dates (beginning with the first
payroll date following the effective date of your required release of claims); provided, however, that if you are a "specified employee" within the
meaning of Section 409A(a)(2)(B)(i) of the Code at the time of your separation from service with the Company, then in accordance with Section 409A(a)(2)(B)(i) of the Code, the Company's
payment of such severance amounts, and the additional prorated bonus severance amount provided in Section 11(ii), will be delayed until six (6) months after your separation from service
as follows: (i) all amounts that would have been paid to you during the 6-month period following your separation from service (if such amounts
were not subject to Section 409A(a)(2)(B)(i) of the Code) shall be delayed and paid to you on the Company's first normal payroll date following such 6-month period (including the
entire amount of the prorated annual bonus payment to be paid as a severance benefit pursuant to Section 11(ii)), with no interest paid on account of such delay, and (ii) the remaining
amount of the base salary severance payments shall be paid to you in substantially equal installments on the Company's normal payroll dates over the following three (3) months. 

Except
as modified herein, all other terms of the Offer Letter shall remain in full force and effect. 

This
Amendment, together with the Offer Letter, constitutes the entire agreement between you and the Company regarding the terms of your employment, effective as of the first business day of the IPO.
It supersedes any prior statements, representations or promises made to you concerning the subjects contained in this letter agreement and the Offer Letter, and only can be modified in a writing
signed by you and a duly authorized director or officer of Epocrates. 

Please
sign below if these terms are acceptable to you. 

Understood and Agreed:  

	/s/ John Owens
 John Owens

Vice President

Human Resources

Epocrates, Inc.	 	/s/ Richard H. Van Hoesen
 Richard H. Van Hoesen

Chief Financial Officer

Senior Vice President, Finance

Epocrates, Inc.
	

4/15/08
 Date	
 	

4/15/08
 Date

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Exhibit 10.16  

 
 

2008 Cash Bonus Plan    
    

Eligibility:  

	•
	All
employees at director level or above employed by the Company at the time of the bonus payout in 2009. If an employee becomes eligible (i.e., is hired or promoted
during 2008), the bonus for that employee will be prorated based upon the period during which he was eligible. 

Target Bonus:  

	•
	

	Executive Management
	 	% of Base Salary
	 
	Kirk M. Loevner	 	 	50	%
	Jeffrey A. Tangney	 	$	40,000	 
	Richard H. Van Hoesen	 	 	35	%
	Robert J. Quinn	 	 	35	%
	John Owens	 	 	30	%
	Paul F. Banta	 	 	30	%
	Allan Wilsker	 	 	25	%
	Michelle Snyder	 	 	25	%

	•
	Other
vice presidents at targets from 15% to 22.5% of base salary as approved by the CEO.

	•
	Directors
at targets from 7.5% to 10% of base salary as approved by the CEO.

	•
	Managers
and other key individual contributors do not participate in the 2008 Cash Bonus Plan, but may be put in individual bonus programs as appropriate based on specific
objectives and performance. 

Bonus Metrics:  

	•
	Based
on achievement of bookings, revenue and Modified EBITDA as set forth in the 2008 Business Plan.

	•
	1/3rd of
bonus based equally on each of bookings, revenue and Modified EBITDA attainment, independently determined.

	•
	No
bonus is paid if either bookings or revenue are below 92% of the 2008 Business Plan targets.

	•
	Otherwise,
the Effective Bonus for each component is independently calculated based on performance against the 2008 Business Plan bookings, revenue and Modified EBITDA
targets, respectively, up to a maximum of 200% of the target bonus. 

QuickLinks

2008 Cash Bonus Plan

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