Document:

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                                EIGHTH AMENDMENT

                    TO AMENDED AND RESTATED CREDIT AGREEMENT

         This Eighth Amendment to Amended and Restated Credit Agreement
("Amendment"), effective as of March 18, 2003, is made and entered into by and
between REDHOOK ALE BREWERY, INCORPORATED, a Washington corporation
("Borrower"), and U.S. BANK NATIONAL ASSOCIATION, a national banking
association, ("U.S. Bank"). Words and phrases with initial capital letters have
the meanings given to them in Article I of this Amendment.

                                    RECITALS:

         A.       On or about June 5, 1995, U.S. Bank and Borrower entered into
that certain amended and restated credit agreement (together with all
amendments, supplements, exhibits, and modifications thereto, the "Credit
Agreement"), whereby U.S. Bank agreed to make loans and advances of credit to
Borrower on the terms and conditions set forth therein.

         B.       Borrower and U.S. Bank have entered into seven amendments to
the Credit Agreement dated as of July 25, 1996; September 15, 1997; February 22,
1999; August 10, 2000; June 19, 2001; December 31, 2001 and as of June 21, 2002,
respectively.

         C.       Borrower and U.S. Bank have agreed to amend the Credit
Agreement again as set forth in this Amendment.

                  NOW, THEREFORE, in consideration of the mutual covenants and
conditions set forth herein, the parties agree as follows:

ARTICLE I. DEFINITIONS AND AMENDMENT

         1.1      DEFINED TERMS

         As used in this Amendment, words and phrases with initial capital
letters shall have the meanings given to them in the Credit Agreement, except as
otherwise defined herein, or as the context otherwise requires.

         1.2      INCORPORATION OF RECITALS AND EXHIBITS

         The foregoing recitals are incorporated into this Amendment by
reference. All references to "Exhibits" contained herein are references to
exhibits attached to this Amendment, the terms and conditions of which are made
a part of this Amendment for all purposes.
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         1.3      AMENDMENT

         The Credit Agreement and the other Loan Documents are hereby amended as
set forth herein. Except as specifically provided herein, all of the terms and
conditions of the Credit Agreement and each of the other Loan Documents and all
amendments thereto shall remain in full force and effect throughout the terms of
the Loans and any extensions or renewals thereof.

ARTICLE II. NEGATIVE COVENANTS

         2.1      CONSOLIDATED TANGIBLE NET WORTH

         Section 7.15 of the Credit Agreement is hereby amended in its entirety
to read as follows:

                  7.15 TANGIBLE NET WORTH

                  Permit Consolidated Tangible Net Worth at any time during the
         term of the Loans to be less than $63,000,000.

            2.2         WORKING CAPITAL

            Section 7.18 of the Credit Agreement is hereby amended in its
entirety to read as follows:

                  7.18 WORKING CAPITAL

                        Permit Borrower's Consolidated current assets to be less
            than $2,500,000 in excess of Borrower's Consolidated current
            liabilities (excluding the principal balance outstanding under the
            Revolving Loan, the principal balance outstanding under the
            Revolving Term Loan prior to the expiration of the Borrowing Period,
            and nonoperating payables (payables for items that when paid may be
            capitalized)), as of the end of any fiscal quarter of Borrower
            during the terms of the Loans.

            2.3         FIXED CHARGE COVERAGE

            Section 7.17 of the Credit Agreement is amended, in part, to change
the ratio from less than 1.00:1 to less than 1.15:1.

            Provided, however, that in calculating the Fixed Charge Coverage
Ratio during the first two quarters of calendar year 2003, Unfunded Capital
Expenditures associated with the Widmer Project shall be excluded from the first
quarter 2003 and from the second quarter 2003, as expensed. In the aggregate,
the excluded Unfunded Capital Expenditures associated with the Widmer Project
for both quarters shall not exceed $750,000.
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ARTICLE III. CONDITIONS PRECEDENT

         U.S. Bank shall have no obligation to modify the terms of the Credit
Agreement as provided in this Amendment unless the following conditions have
been fulfilled to the satisfaction of U.S. Bank:

         (a)      U.S. Bank shall have received this Amendment, duly executed
and delivered by Borrower.

         (b)      There shall not then exist any Default or Event of Default as
of the date hereof.

         (c)      All representations and warranties of Borrower contained
herein or made in writing in connection herewith shall be true and correct as of
the date hereof.

         (d)      There shall have been no material adverse change in the
financial condition of the Borrower subsequent to December 31, 2002.

         (e)      U.S. Bank shall have received, duly executed and delivered by
Borrower, such financing statements or other instruments, in form and substance
satisfactory to U.S. Bank, that U.S. Bank may deem appropriate to perfect its
security interests in any Collateral.

         (f)      All corporate proceedings of Borrower and its Subsidiaries
shall be satisfactory in form and substance to U.S. Bank, and U.S. Bank shall
have received all information and copies of all documents, including records of
all corporate proceedings, that U.S. Bank has requested in connection therewith,
such documents where appropriate to be certified by proper corporate authorities
or Governmental Bodies.

ARTICLE IV. GENERAL PROVISIONS

         4.1      REPRESENTATIONS AND WARRANTIES

         Borrower hereby represents and warrants to U.S. Bank that, to the best
knowledge and belief of Borrower, as of the date of this Amendment, there exists
no Default or Event of Default. All representations and warranties of Borrower
contained in the Credit Agreement and the other Loan Documents, or otherwise
made in writing in connection therewith, are true and correct as of the date of
this Amendment. Borrower acknowledges and agrees that all of Borrower's
Indebtedness to U.S. Bank is payable without offset, defense, counterclaim or
claim of recoupment.

         4.2      SECURITY

         The parties acknowledge and agree that all security agreements,
financing statements, and other Loan Documents creating, perfecting, or
evidencing U.S. Bank's security interest in the Collateral shall remain in full
force and effect and shall secure and shall continue to
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secure payment and performance of all Loans and other Indebtedness of Borrower
to U.S. Bank

         4.3      GUARANTIES

         The parties hereby acknowledge and agree that all guaranties now
existing or hereafter obtained by U.S. Bank shall remain in full force and
effect, are valid and enforceable in accordance with their terms, and are not
subject to offset, defense, counterclaim or claim of recoupment.

         4.4      EXPENSES

         Borrower shall reimburse U.S. Bank for all of its out-of-pocket
expenses incurred in connection with this Amendment promptly upon demand. Such
expenses shall include, without limitation, reasonable attorney fees,
examination expenses, and filing fees.

         4.5      COUNTERPARTS

         This Amendment may be executed in one or more counterparts, each of
which shall constitute an original agreement, but all of which together shall
constitute one and the same agreement.

         4.6      STATUTORY NOTICE

         ORAL AGREEMENTS OR ORAL COMMITMENTS TO LOAN MONEY, EXTEND CREDIT, OR TO
FORBEAR FROM ENFORCING REPAYMENT OF A DEBT ARE NOT ENFORCEABLE UNDER WASHINGTON
LAW.

         IN WITNESS WHEREOF, U.S. Bank and Borrower have caused this Amendment
to be duly executed by their respective duly authorized officers or agents as of
the date first above written.

                             REDHOOK ALE BREWERY, INCORPORATED

                             By /s/ David J. Mickelson
                                -----------------------------------------------
                                David Mickelson, Executive Vice President

                             U.S. BANK NATIONAL ASSOCIATION

                             By /s/ Kevin Blain
                                -----------------------------------------------
                                Kevin Blair, Vice President
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         By execution of this Amendment, the undersigned Guarantor approves of
the changes to the Credit Agreement set forth herein, reaffirms its Guaranty,
and acknowledges and agrees that its obligations under its Guaranty are not
subject to any defense, offset, counterclaim or claim of recoupment.

                                 REDHOOK OF NEW HAMPSHIRE, INC.

                                 By /s/ David J. Mickelson
                                    -------------------------------------------
                                    David Mickelson, Executive Vice President<PAGE>

                                                                    Exhibit 10.1

                            FIRST AMENDMENT TO LEASE

                 [Nexus Canyon Park / Northwest Biotherapeutics]

      THIS FIRST AMENDMENT TO LEASE (this "First Amendment") is effective as of
April 15, 2003 ("Effective Date"), by and between NEXUS CANYON PARK LLC, a
Delaware limited liability company (formerly a California limited liability
company), and NORTHWEST BIOTHERAPEUTICS, INC., a Delaware corporation,
"Landlord" and "Tenant" respectively, under that certain Lease dated as of
October 22, 1999 (the "Lease") for the Premises described in Section 1.1 of the
Lease, consisting of approximately 38,776 square feet of Rentable Area in the
Building located at 21720-23rd Drive S.E., Bothell, Washington, on real property
legally described as Tract 21-B of Canyon Park Business Center Binding Site Plan
recorded under Recording No. 9708195005, records of Snohomish County,
Washington, being a portion of the Northwest Quarter of Section 29, Township 27
North, Range 5 East, W.M.

      NOW, THEREFORE, for valuable consideration, the receipt and adequacy of
which are acknowledged, the Lease is hereby amended as follows:

      1. LEASE PREMISES. Section 1.1 of the Lease is corrected to reflect that
the Building consists of approximately 152,050 square feet of Rentable Area.

      2. RENTABLE AREA. Section 2.1.3 of the Lease is amended to provide that
the Rentable Area of the Premises is 34,104 square feet (reduced from 38,776
square feet), as shown on the new Exhibit "B" attached hereto, effective on the
Effective Date. On or before the Effective Date, Tenant shall vacate that
portion of the Premises which will no longer be part of the Premises (the
"Released Space"), and shall restore and return the Released Space to the
condition it was in when first occupied by Tenant, reasonable wear and tear
excepted; provided, however, Tenant shall leave in place all improvements and
fixtures (other than trade fixtures) installed in the Released Space except to
the extent Landlord consents to the removal of any such property.

      3. BASIC ANNUAL RENT AND MONTHLY INSTALLMENT OF BASIC ANNUAL RENT. Section
2.1.4 of the Lease is amended to provide that Basic Annual Rent is reduced to
$1,081,656.96 and Section 2.1.5 of the Lease is amended to provide that the
Monthly Installment of Basic Annual Rent is reduced to $90,138.08, effective on
the Effective Date. Pursuant to Section 6.1 of the Lease, the Basic Annual Rent
then in effect shall be increased each year by three and one-half percent (3.5%)
on each annual anniversary of the Term Commencement Date for the initial 10-year
term of the Lease. The next such increase shall occur on September 1, 2003.

      4. TENANT'S PRO RATA SHARE. Section 2.1.6 of the Lease is amended to
provide that Tenant's Pro Rata Share is 22.4% of the Project.

      5. PARKING FACILITIES. Section 15.3 of the Lease is amended to provide
that Tenant shall be entitled to use 84 parking spaces (previously 91 parking
spaces).
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      6. EXHIBIT B. Exhibit "B" attached to the Lease is replaced with the new
Exhibit "B" attached hereto and incorporated herein by this reference.

      In all other respects, the Lease shall remain in full force and effect as
originally written.

      Terms with an initial capital letter not defined in this First Amendment
shall have the meaning given them in the Lease.

      IN WITNESS WHEREOF, the parties hereto have executed this First Amendment
to Lease as of the date first above written.

LANDLORD:

NEXUS CANYON PARK LLC
A Delaware limited liability company

        By:   Canyon Nexus, Inc.
              A California corporation
              Its Manager

              By:    ______________________________
                     Michael J. Reidy
                     Chief Executive Officer

TENANT:

NORTHWEST BIOTHERAPEUTICS, INC.
A Delaware corporation

By:     ______________________________
        Name:  Daniel O. Wilds
        Title: Chairman, President & CEO
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                                 ACKNOWLEDGMENT

STATE OF CALIFORNIA  )
                     )ss:
COUNTY OF SAN DIEGO  )

On _________, 2003, before me, _________________________________,
Notary Public, personally appeared MICHAEL J. REIDY, personally known to me or
proved to me on the basis of satisfactory evidence to be the person whose name
is subscribed to the within instrument and acknowledged to me that he executed
the same in his authorized capacity, and that by his signature on the instrument
the person, or the entity upon behalf of which the person acted, executed the
instrument.

WITNESS my hand and official seal.

_____________________________________
Signature

                                 ACKNOWLEDGMENT

STATE OF  _____________   )
                          )ss:
COUNTY OF _____________   )

On __________, 2003, before me, _________________________________,
Notary Public, personally appeared _______________________, personally known to
me or proved to me on the basis of satisfactory evidence to be the person whose
name is subscribed to the within instrument and acknowledged to me that he
executed the same in his authorized capacity, and that by his signature on the
instrument the person, or the entity upon behalf of which the person acted,
executed the instrument.

WITNESS my hand and official seal.

_____________________________________
Signature

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