Document:

Form of Subscription Agreement

 Exhibit 10.1 
 INSERT THERAPEUTICS, INC. 
 SUBSCRIPTION AGREEMENT 

 TABLE OF CONTENTS 
  

							
	SUBSCRIPTION AGREEMENT	  	1
			
	1.	  	Purchase and Sale of Units	  	1
		  	1.1	  	 Sale and Issuance of Units
	  	1
		  	1.2	  	 Closing
	  	1
			
	2.	  	Representations and Warranties of the Company	  	2
		  	2.1	  	 Organization, Good Standing and Qualification
	  	2
		  	2.2	  	 Capitalization and Voting Rights
	  	2
		  	2.3	  	 Subsidiaries
	  	3
		  	2.4	  	 Authorization
	  	3
		  	2.5	  	 Valid Issuance of Preferred and Common Stock
	  	4
		  	2.6	  	 Governmental Consents
	  	4
		  	2.7	  	 Offering
	  	4
		  	2.8	  	 Litigation
	  	4
		  	2.9	  	 Proprietary Information Agreements
	  	5
		  	2.10	  	 Patents and Trademarks
	  	5
		  	2.11	  	 Compliance with Other Instruments
	  	5
		  	2.12	  	 Agreements; Action
	  	5
		  	2.13	  	 Related-Party Transactions
	  	6
		  	2.14	  	 No Undisclosed Liabilities
	  	6
		  	2.15	  	 Permits
	  	6
		  	2.16	  	 Environmental and Safety Laws
	  	6
		  	2.17	  	 Disclosure
	  	7
		  	2.18	  	 Registration Rights
	  	7
		  	2.19	  	 Title to Property and Assets
	  	7
		  	2.20	  	 Labor Agreements and Actions
	  	7
			
	3.	  	Representations and Warranties of each Investor	  	7
		  	3.1	  	 Authorization
	  	7
		  	3.2	  	 Purchase Entirely for Own Account
	  	8
		  	3.3	  	 Disclosure of Information
	  	8
		  	3.4	  	 Investment Experience
	  	8
		  	3.5	  	 Accredited Investor
	  	8
		  	3.6	  	 Restricted Securities
	  	8

  

 i. 

							
		  	3.7	  	 Legends
	  	8
			
	4.	  	Conditions of each Investor’s Obligations at Closing	  	9
		  	4.1	  	 Representations and Warranties
	  	9
		  	4.2	  	 Performance
	  	9
		  	4.3	  	 Qualifications
	  	9
		  	4.4	  	 Proceedings and Documents
	  	9
		  	4.5	  	 Restated Certificate
	  	9
		  	4.6	  	 Joinder Agreement
	  	9
		  	4.7	  	 Investors’ Rights Agreement Amendment
	  	9
		  	4.8	  	 Preemptive Rights Offer Waiver
	  	9
			
	5.	  	Conditions of the Company’s Obligations	  	10
		  	5.1	  	 Representations and Warranties
	  	10
		  	5.2	  	 Payment of Purchase Price
	  	10
		  	5.3	  	 Qualifications
	  	10
		  	5.4	  	 Preemptive Rights Offer Waiver
	  	10
			
	6.	  	Miscellaneous	  	10
		  	6.1	  	 Survival
	  	10
		  	6.2	  	 Successors and Assigns
	  	10
		  	6.3	  	 Governing Law
	  	10
		  	6.4	  	 Titles and Subtitles
	  	10
		  	6.5	  	 Notices
	  	11
		  	6.6	  	 Finder’s Fee
	  	11
		  	6.7	  	 Aggregation of Stock
	  	11
		  	6.8	  	 Amendments and Waivers
	  	11
		  	6.9	  	 Severability
	  	11
		  	6.10	  	 Entire Agreement
	  	11
		  	6.11	  	 Counterparts; Facsimile Signatures
	  	12

  

					
		 	SCHEDULE A	 	 Schedule of Exceptions

			
		 	EXHIBIT A	 	 Amended and Restated Certificate of Incorporation

			
		 	EXHIBIT B	 	 Joinder Agreement

			
		 	EXHIBIT C	 	 Investors’ Rights Agreement Amendment

			
		 	EXHIBIT D	 	 Warrant Agreement

  

 ii. 

 SUBSCRIPTION AGREEMENT 
 THIS SUBSCRIPTION AGREEMENT (this “Agreement”) is made on
            , 2006, among Insert Therapeutics, Inc., a Delaware corporation (the “Company”) and the undersigned investors party hereto (the
“Investors”). 
 RECITALS 
 WHEREAS, Investors wish to purchase, and the Company wishes to sell, units (“Units”) at a purchase price of $1.00 per Unit, with each Unit shall consist of one share of the Company’s
Series C-2 Preferred Stock (the “Series C-2 Preferred Stock”) and 40% warrant coverage (the “Warrant”) to purchase shares of the Company’s Series D Preferred Stock (the “Series D
Preferred Stock,” and, together with the Units, the Series C-2 Preferred Stock and the Warrants, the “Securities”). 
 NOW, THEREFORE BE IT RESOLVED, in consideration of the mutual covenants, agreements and conditions, and upon acknowledgement of each of the parties of the receipt of valuable consideration, the parties herein agree as
follows: 
 1. Purchase and Sale of Units. 
 1.1 Sale and Issuance of Units. 
 (a) The Company shall adopt and file with the Secretary of State of the State of Delaware on or before the Closing (as defined below) the Amended and Restated Certificate of Incorporation in the form attached hereto
as Exhibit A (the “Restated Certificate”). 
 (b) Subject to the terms and conditions of this
Agreement, Investors agree to purchase at the Closing (as defined herein), and the Company agrees to sell and issue to Investors at the Closing such number of Units listed on such Investor’s signature page hereto. 
 1.2 Closing. The purchase and sale of the Units hereunder shall take place at the offices of Arrowhead Research Corporation, at
1:00 P.M. on September     , 2006, or at such other time and place as the Company and Investors mutually agree upon orally or in writing (which time and place are designated as the “Closing”). At
the Closing, the Company shall deliver to each Investor a certificate representing the Series C-2 Preferred Stock and a Warrant that such Investor is purchasing against payment of the purchase price therefor by wire transfer or certified or
cashier’s check or checks (and in any event representing immediately available funds) or cancellation of indebtedness. 
  

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 2. Representations and Warranties of the Company. The Company hereby represents
and warrants to Investors that, except as set forth on the Schedule of Exceptions (the “Schedule of Exceptions”) furnished to Investors prior to execution hereof and attached hereto as Schedule A, which exceptions
shall be deemed to be representations and warranties as if made hereunder: 
 2.1 Organization, Good Standing and
Qualification. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware. The Company is duly qualified to transact business and is in good standing in each jurisdiction in which
the failure to so qualify would have a material adverse effect on its business or properties. 
 2.2 Capitalization and
Voting Rights 
 (a) Authorized Stock. Immediately prior to the Closing, the authorized capital of the Company
consists, or will consist, of: 
 (i) Preferred Stock. Fifty Million (50,000,000) shares of Preferred Stock, par
value $0.0001 (the “Preferred Stock”), including: 
 Series A Preferred Stock, all of which has been
fully converted into Common Stock and no shares remain outstanding. No shares of Series A Preferred Stock may be reissued by the Corporation. 
 Series B Preferred Stock, of which Twenty-One Million Seven Hundred Twenty-One Thousand Three Hundred Eighty-One (21,721,381) shares are the issued and outstanding. The rights, preferences, powers, privileges and
restrictions, qualifications and limitations of the Series B Preferred Stock are set forth in the Restated Certificate. 
 Series C Preferred Stock, of which Four Million (4,000,000) shares are the issued and outstanding. The rights, preferences, powers, privileges and restrictions, qualifications and limitations of the Series C Preferred Stock are set
forth in the Restated Certificate. 
 (ii) Common Stock. One Hundred Million (100,000,000) shares of Common
Stock, par value $0.0001 (“Common Stock”), of which Seventeen Million Sixty Two Thousand Seven Hundred Two (17,062,702) shares are issued and outstanding. 
 (b) Valid Issuance. The outstanding shares of Preferred Stock and Common Stock are all duly and validly authorized and issued,
fully paid and nonassessable, and were issued in compliance with all applicable state and federal laws concerning the issuance of securities. 
 (c) Rights to Acquire. Except for (i) the conversion privileges of the Series C-2 Preferred Stock to be issued under this Agreement, (ii) the rights provided in Section 4 of that certain
Investors’ Rights Agreement previously entered into as of June 4, 2004 

  

 2 

 
by and among the Company, certain Investors and the other parties, thereto (as amended to date, the “Investors’ Rights
Agreement”), (iii) the conversion privileges of the Series B Preferred Stock, the Series C Preferred Stock and the Series D Preferred Stock, (iv) currently outstanding options to purchase Three Million Three Hundred Eighty
Four Thousand Twenty Eight (3,384,028) shares of Common Stock granted to employees, consultants and/or directors pursuant to the Company’s 2000 Stock Option/Stock Issuance Plan (the “Option Plan”) and
(v) Warrants issued under this Agreement, there are not outstanding any options, warrants, rights (including conversion or preemptive rights) or agreements for the purchase or acquisition from the Company of any shares of its capital stock. The
Company has reserved an additional Two Million Seven Hundred Sixty Four Thousand Seven Hundred Ninety Two (2,764,792) shares of its Common Stock for issuance under the Option Plan. 
 (d) Voting of Shares. Other than the Voting Agreement previously entered into as of June 4, 2004 by and among the Company,
certain Investors and other parties thereto (as amended to date, the “Voting Agreement”), the Company is not a party or subject to any agreement or understanding and, to the Company’s knowledge, there is no agreement or
understanding between any persons and/or entities which affects or relates to the voting or giving of written consents with respect to any security or by a director of the Company. 
 (e) Market Stand-Off / Right of First Refusal. To the Company’s best knowledge, all outstanding securities of the Company,
including, without limitation, all outstanding shares of the capital stock of the Company, all shares of the capital stock of the Company issuable upon the conversion or exercise of all convertible or exercisable securities and all other securities
that the Company is obligated to issue, are subject to (i) a one hundred eighty (180) day “market stand-off” restriction upon an initial public offering of the Company’s securities pursuant to a registration statement filed
with the Securities and Exchange Commission (“SEC”) pursuant to the Securities Act of 1933, as amended (the “Act”) and (ii) a right of first refusal in favor of the Company with respect to any
transfer of such securities. 
 2.3 Subsidiaries. Except for the ownership of 480,000 shares of Calando
Pharmaceuticals, Inc., the Company does not presently own or control, directly or indirectly, any interest in any other corporation, association, or other business entity. The Company is not a participant in any joint venture, partnership, or
similar arrangement. 
 2.4 Authorization. All corporate action on the part of the Company, its officers, directors and
stockholders necessary for the authorization, execution and delivery of this Agreement, the Joinder Agreement, in the form attached hereto as Exhibit B (the “Joinder Agreement”) and Amendment No. 2 to the
Investors’ Rights Agreement, in the form attached hereto as Exhibit C (the “Investors’ Rights Agreement Amendment”) (collectively the “Related Agreements”) the performance of all
obligations of the Company hereunder and thereunder, and the authorization, sale and issuance of the Series C-2 Preferred Stock and Warrants being sold hereunder, the Series D Preferred Stock issuable upon exercise of the Warrants and the Common
Stock issuable upon conversion of the Series C-2 Preferred Stock and Series D Preferred Stock (upon issuance after exercise of the Warrants), has been taken or will be taken prior to the Closing. This Agreement and the Related Agreements constitute
valid and legally binding obligations of the Company, enforceable in accordance with their respective terms, except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of 
  

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general application affecting enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availability of specific
performance, injunctive relief or other equitable remedies, and (iii) to the extent the indemnification provisions contained in the Related Agreements may be limited by applicable federal or state securities laws. 
 2.5 Valid Issuance of Preferred and Common Stock. The Series C-2 Preferred Stock that is being purchased by Investors hereunder,
when issued, sold and delivered in accordance with the terms of this Agreement for the consideration expressed herein, and the Series D Preferred Stock when issued upon exercise of the Warrants will be duly and validly issued, fully paid and
nonassessable and will be free of restrictions on transfer, other than restrictions on transfer (i) under this Agreement, the Investor’s Rights Agreement, the Voting Agreement and the Co-Sale and Right of First Refusal Agreement (each as
amended), (ii) under applicable state and federal securities laws and (iii) otherwise imposed as a result of actions taken by Investors. The Common Stock issuable upon conversion of the Series C-2 Preferred Stock and Series D Preferred
Stock (upon issuance after exercise of the Warrants) purchased under this Agreement has been duly and validly reserved for issuance and, upon issuance in accordance with the terms of the Restated Certificate, will be duly and validly issued, fully
paid and nonassessable and will be free of restrictions on transfer, other than restrictions on transfer (i) under this Agreement, the Investor’s Rights Agreement and the Voting Agreement (each as amended), (ii) under applicable state
and federal securities laws and (iii) otherwise imposed as a result of actions taken by Investors. 
 2.6 Governmental
Consents. No consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority on the part of the Company is required in connection with the
consummation of the transactions contemplated by this Agreement and the Related Agreements, except for such consents, approvals, orders, authorizations, registrations, qualifications, designations, declarations or filings which are not required to
be obtained prior to the Closing, and such filings as are required pursuant to applicable federal and state securities laws and blue sky laws, which filings will be effected within the required statutory period. 
 2.7 Offering. Subject in part to the truth and accuracy of each Investor’s representations set forth in Section 3
of this Agreement, the offer, sale and issuance of the Units as contemplated by this Agreement are exempt from the registration requirements of the Act, and the qualification or registration requirements of applicable state blue sky laws, as such
registration requirements and laws currently exist. 
 2.8 Litigation. There is no action, suit, proceeding or
investigation pending or, to the Company’s knowledge, currently threatened against the Company that questions the validity of this Agreement or the Related Agreements, or the right of the Company to enter into such agreements or to consummate
the transactions contemplated hereby and thereby, or that might result, either individually or in the aggregate, in any material adverse changes in the business, assets or condition of the Company, financially or otherwise, or any change in the
current equity ownership of the Company. The Company is not a party or subject to the provisions of any order, writ, injunction, judgment or decree of any court or government agency or instrumentality. There is no action, suit, proceeding or
investigation by the Company currently pending or that the Company intends to initiate. 
  

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 2.9 Proprietary Information Agreements. Each employee of the Company has executed
a Proprietary Information and Inventions Agreement in substantially the form provided to Investors. The Company is not aware that any such employee is in violation thereof. 
 2.10 Patents and Trademarks. To its knowledge (but without having conducted any special investigation or search), the Company
possesses all patents, patent rights, trademarks, trademark rights, service marks, service mark rights, trade names, trade name rights, copyrights, trade secrets, licenses, information and other proprietary rights and processes necessary for its
business, as now conducted and as presently proposed to be conducted (collectively, the “Intellectual Property”), without any conflict with or infringement of the valid rights of others, except for Intellectual Property that
the Company does not now possess, but that the Company reasonably believes can be acquired on commercially reasonable terms. The Company has not received any notice of infringement upon or conflict with the asserted rights of others with respect to
Intellectual Property. To the Company’s knowledge, all of the issued patents to which the Company has an exclusive license or right to use are valid and enforceable. 
 2.11 Compliance with Other Instruments. The Company is not in violation of any material provision of its Restated Certificate or
Bylaws nor, to its knowledge, of any instrument, judgment, order, writ, decree or contract, statute, rule or regulation to which the Company is subject and a violation of which would have a material adverse effect on the condition, financial or
otherwise, or operations of the Company. The execution, delivery and performance of this Agreement and the Related Agreements, and the consummation of the transactions contemplated hereby and thereby will not result in any such violation, or be in
conflict with or constitute, with or without the passage of time and giving of notice, either a default under any such provision or an event that results in the creation of any lien, charge or encumbrance upon any assets of the Company or the
suspension, revocation, impairment, forfeiture or nonrenewal of any material permit, license, authorization or approval applicable to the Company, its business or operations or any of its assets or properties. 
 2.12 Agreements; Action. 
 (a) Except for agreements explicitly contemplated hereby, there are no agreements or understandings between the Company and any of its officers, directors, affiliates or any affiliate thereof. 
 (b) There are no agreements, understandings, instruments, contracts, judgments, orders, writs or decrees to which the Company is a party
or by which it is bound that may involve (i) obligations (contingent or otherwise) of, or payments to the Company, in excess of $10,000, other than obligations of, or payments to, the Company arising from purchase or sale agreements entered
into in the ordinary course of business, or (ii) provisions materially restricting the development, manufacture or distribution of the Company’s products or services. 
 (c) The Company has not (i) declared or paid any dividends or authorized or made any distribution upon or with respect to any class
or series of its capital stock, (ii) incurred any indebtedness for money borrowed or any other liabilities individually in 

  

 5 

 
excess of $10,000 or, in the case of indebtedness and/or liabilities individually less than $10,000, in excess of $25,000 in the aggregate, (iii) made
any loans or advances to any person, other than ordinary advances for travel expenses, or (iv) sold, exchanged or otherwise disposed of any of its assets or rights. 
 (d) For the purposes of subsections (b) and (c) above, all indebtedness, liabilities, agreements, understandings, instruments
and contracts involving the same person or entity (including persons or entities the Company has reason to believe are affiliated therewith) shall be aggregated for the purpose of meeting the individual minimum dollar amounts of such subsections.

 2.13 Related-Party Transactions. No employee, officer or director of the Company or member of his or her immediate
family is indebted to the Company, nor is the Company indebted (or committed to make loans or extend or guarantee credit) to any of them. To the best of the Company’s knowledge, other than in Arrowhead or in any of Arrowhead’s
subsidiaries, none of such persons has any direct or indirect ownership interest in any firm or corporation with which the Company is affiliated or with which the Company has a business relationship, or any firm or corporation that competes with the
Company, except that employees, officers or directors of the Company and members of their immediate families may own stock in publicly traded companies that may compete with the Company. No member of the immediate family of any officer or director
of the Company is directly or indirectly interested in any material contract with the Company. 
 2.14 No Undisclosed
Liabilities. Except as set forth in the consolidated financial statements of Arrowhead Research Corporation at June 30, 2006 and for the three months then ended, the Company does not have any liabilities (whether accrued, absolute,
unliquidated, contingent or otherwise, whether or not known to the Company, whether due or to become due and regardless of when asserted) arising out of transactions entered into at or prior to the Closing, or any action or inaction at or prior to
the Closing or any state of facts existing at or prior to the Closing other than (i) liabilities and obligations that have arisen after June 30, 2006 in the ordinary course of business (none of which is material and none of which is a
liability resulting from breach of contract, breach of warranty, tort, infringement, claim or lawsuit), and (ii) obligations under contracts and commitments incurred in the ordinary course of business that would not be required to be reflected
in financial statements prepared in accordance with generally accepted accounting principles. The Company is not a guarantor or indemnitor of any indebtedness of any other person, firm or corporation. 
 2.15 Permits. The Company has all franchises, permits, licenses and any similar authority necessary for the conduct of its business
as now being conducted by it, the lack of which could materially and adversely affect the business, properties or financial condition of the Company, and the Company believes it can obtain, without undue burden or expense, any similar authority for
the conduct of its business as proposed to be conducted. The Company is not in default in any material respect under any of such franchises, permits, licenses or other similar authority. 
 2.16 Environmental and Safety Laws. To its knowledge, the Company is not in violation of any applicable statute, law or regulation
relating to the environment or 
  

 6 

 
occupational health and safety, and to its knowledge, no material expenditures are or will be required in order to comply with any such existing statute, law
or regulation. 
 2.17 Disclosure. The Company has fully provided Investors with all the information that such
Investors have requested for deciding whether to purchase the Units. Neither this Agreement (including all the exhibits and schedules hereto) nor any other statements or certificates made or delivered in connection herewith contains any untrue
statement of a material fact or omits to state a material fact necessary to make the statements herein or therein not misleading in light of the circumstances under which they were made. 
 2.18 Registration Rights. Except as provided in the Investors’ Rights Agreement, the Company has not granted or agreed to
grant any registration rights, including piggyback rights, to any person or entity. 
 2.19 Title to Property and
Assets. The property and assets used by the Company in its business are owned by the Company free and clear of all mortgages, liens, loans and encumbrances, except for (i) statutory liens for the payment of current taxes that are not yet
delinquent, and (ii) for liens, encumbrances and security interests that arise in the ordinary course of business and minor defects in title, none of which, individually or in the aggregate, materially impair the Company’s ownership or use
of such property or assets. With respect to the property and assets it leases, the Company is in material compliance with such leases and, to its knowledge, holds a valid leasehold interest free of any liens, claims or encumbrances, subject to
clauses (i)-(ii). 
 2.20 Labor Agreements and Actions. The Company is not bound by or subject to any contract,
commitment or arrangement with any labor union, and no labor union has requested or, to the Company’s knowledge, has sought to represent any of the employees, representatives or agents of the Company. There is no strike or other labor dispute
involving the Company pending, or to the Company’s knowledge, threatened, that could have a material adverse effect on the assets, properties, financial condition, operating results or business of the Company, nor is the Company aware of any
labor organization activity involving its employees. The Company is not aware that any officer or key employee, or that any group of key employees, intends to terminate their employment with the Company, nor does the Company have a present intention
to terminate the employment of any of the foregoing. The employment of each officer and employee of the Company is terminable at the will of the Company. The Company is not a party to or bound by any currently effective employment contract, deferred
compensation agreement, bonus plan, incentive plan, profit sharing plan, retirement agreement or other employee compensation agreement. To its knowledge, the Company has complied in all material respects with all applicable state and federal equal
employment opportunity and other laws related to employment. 
 3. Representations and Warranties of each Investor.
Each Investor hereby represents, warrants and covenants that: 
 3.1 Authorization. Such Investor has full power and
authority to enter into this Agreement and the Related Agreements to which it is a party, and each such agreement constitutes its valid and legally binding obligation, enforceable in accordance with its terms 
  

 7 

 
except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of
creditors’ rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies, and (iii) to the extent the indemnification provisions contained in the Related
Agreements may be limited by applicable federal or state securities laws. 
 3.2 Purchase Entirely for Own Account.
This Agreement is made with such Investor in reliance upon such Investor’s representation to the Company, which by such Investor’s execution of this Agreement, such Investor hereby confirms that the Securities will be acquired for
investment for such Investor’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that such Investor has no present intention of selling, granting any participation in or otherwise
distributing the same. By executing this Agreement, such Investor further represents that such Investor does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations to such person or to
any third person, with respect to any of the Securities. 
 3.3 Disclosure of Information. Such Investor believes it
has received all the information it considers necessary or appropriate for deciding whether to purchase the Units. Such Investor further represents that it has had an opportunity to ask questions and receive answers from the Company regarding the
terms and conditions of the offering of the Units and the business, properties, prospects and financial condition of the Company. The foregoing, however, does not limit or modify the representations and warranties of the Company in
Section 2 of this Agreement or the right of such Investor to rely thereon. 
 3.4 Investment Experience.
Such Investor is an investor in securities of companies in the development stage and acknowledges that it is able to fend for itself, can bear the economic risk of its investment, and has such knowledge and experience in financial or business
matters that it is capable of evaluating the merits and risks of the investment in the Units. If other than an individual, such Investor also represents it has not been organized for the purpose of acquiring the Units. 
 3.5 Accredited Investor. Such Investor is an “accredited investor” within the meaning of SEC Rule 501 of Regulation D, as
presently in effect. 
 3.6 Restricted Securities. Such Investor understands that the Securities it is purchasing are
characterized as “restricted securities” under the federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering, and that under such laws and applicable regulations, such
Securities may be resold without registration under the Act only in certain limited circumstances. In the absence of an effective registration statement covering the Securities or an available exemption from registration under the Act, the Series
C-2 Preferred Stock, the Warrants, the Series D Preferred Stock issued upon exercise of the Warrants (and any Common Stock issued on conversion of the Preferred Stock) must be held indefinitely. 
 3.7 Legends. It is understood that the certificates evidencing the Securities may bear one or all of the following legends:

  

 8 

 (a) “These securities have not been registered under the Securities Act of 1933, as
amended. They may not be sold, offered for sale, pledged or hypothecated in the absence of a registration statement in effect with respect to the securities under such Act or an opinion of counsel satisfactory to the Company that such registration
is not required or unless sold pursuant to Rule 144 of such Act.” 
 (b) Any legend required by applicable laws.

 4. Conditions of each Investor’s Obligations at Closing. The obligations of each Investor under
Section 1.1(b) of this Agreement are subject to the fulfillment on or before the Closing of each of the following conditions: 
 4.1 Representations and Warranties. The representations and warranties of the Company contained in Section 2 shall be true on and as of the Closing with the same effect as though such
representations and warranties had been made on and as of the date of such Closing. 
 4.2 Performance. The Company
shall have performed and complied with all agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by it on or before the Closing. 
 4.3 Qualifications. All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the
United States or of any state that are required in connection with the lawful issuance and sale of the Securities in the Closing pursuant to this Agreement shall be duly obtained and effective as of the Closing, other than such authorizations,
approvals or permits or other filings which may be timely made after the Closing. 
 4.4 Proceedings and Documents. All
corporate and other proceedings in connection with the transactions contemplated at the Closing and all documents incident thereto shall be reasonably satisfactory in form and substance to Investors, and it shall have received all such counterpart
original and certified or other copies of such documents as it may reasonably request. 
 4.5 Restated Certificate. The
Restated Certificate shall have been filed with the Secretary of State of the State of Delaware and shall continue to be in full force and effect as of the Closing. 
 4.6 Joinder Agreement. The Company, Investors and any other required parties shall have entered into the Joinder Agreement.

 4.7 Investors’ Rights Agreement Amendment. The Company, certain Investors and any other required parties shall
have entered into the Investors’ Rights Agreement Amendment. 
 4.8 Preemptive Rights Offer Waiver. The California
Institute of Technology, and any other “Major Investors” (as defined in the Investors’ Rights Agreement), shall have waived their right of first offer under Section 4 of the Investors’ Rights Agreement, in 
  

 9 

 
connection with the transactions contemplated by this Agreement, in a form and manner satisfactory to Investors. 
 5. Conditions of the Company’s Obligations. The obligations of the Company to Investors under this Agreement are subject to
the fulfillment on or before the Closing of each of the following conditions: 
 5.1 Representations and Warranties.
The representations and warranties of each Investor contained in Section 3 shall be true on and as of the Closing with the same effect as though such representations and warranties had been made on and as of the date of such Closing.

 5.2 Payment of Purchase Price. Each Investor shall have delivered to the Company the purchase price specified in
Section 1.1(b). 
 5.3 Qualifications. All authorizations, approvals or permits, if any, of any
governmental authority or regulatory body of the United States or of any state that are required in connection with the lawful issuance and sale of the Securities in the Closing pursuant to this Agreement shall be duly obtained and effective as of
the Closing, other than such authorizations, approvals or permits or other filings which may be timely made after the Closing. 
 5.4 Preemptive Rights Offer Waiver. The California Institute of Technology, and any other “Major Investors” (as defined in the Investors’ Rights Agreement), shall have waived their right of first offer under
Section 4 of the Investors’ Rights Agreement, in connection with the transactions contemplated by this Agreement, in a form and manner satisfactory to the Company. 
 6. Miscellaneous. 
 6.1 Survival. The warranties, representations and covenants of the Company and each Investor contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and the
Closing and shall in no way be affected by any investigation of the subject matter thereof made by or on behalf of any Investor or the Company. 
 6.2 Successors and Assigns. Except as otherwise provided herein, the terms and conditions of this Agreement shall inure to the benefit of, and be binding upon, the respective successors and assigns of the
parties (including transferees of any Securities). Nothing in this Agreement, express or implied, is intended to confer upon any party, other than the parties hereto or their respective successors and assigns, any rights, remedies, obligations or
liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 
 6.3 Governing Law.
This Agreement shall be governed by and construed under the laws of the State of California as applied to agreements among California residents entered into and to be performed entirely within California. 
 6.4 Titles and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be
considered in construing or interpreting this Agreement. 
  

 10 

 6.5 Notices. All notices required or permitted hereunder shall be in writing and
shall be deemed effectively given: (i) upon personal delivery to the party to be notified, (ii) when sent by confirmed telex or facsimile if sent during normal business hours of the recipient, if not, then on the next business day;
(iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) day after deposit with a nationally recognized overnight courier, specifying next day
delivery, with written verification of receipt. All communications shall be sent to the address as set forth on the signature page hereof or at such other address as such party may designate by ten (10) days’ advance written notice to the
other parties hereto. 
 6.6 Finder’s Fee. Each party represents that it neither is nor will be obligated for any
finders’ fee or commission in connection with this transaction, except that the Company may pay third party finders or advisors up to an 8% finder’s fee for Units placed by such third party, with such fee paid in cash or in Units, in the
Company’s sole and absolute discretion. Each Investor agrees to indemnify and to hold harmless the Company from any liability for any commission or compensation in the nature of a finders’ fee (and the costs and expenses of defending
against such liability or asserted liability) for which such Investor or any of its officers, partners, employees or representatives is responsible. The Company agrees to indemnify and hold harmless each Investor from any liability for any
commission or compensation in the nature of a finders’ fee (and the costs and expenses of defending against such liability or asserted liability) for which the Company or any of its officers, employees or representatives is responsible.

 6.7 Aggregation of Stock. All issued and outstanding shares of the Series C-2 Preferred Stock, Series D Preferred
Stock and Common Stock issued upon conversion thereof held or acquired by affiliated entities or persons shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 
 6.8 Amendments and Waivers. Any term of this Agreement may be amended, and the observance of any term of this Agreement may be
waived (either generally or in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the holders of a majority of the Common Stock that is issuable or issued upon conversion of the issues
and outstanding Series C-2 Preferred Stock and Series D Preferred Stock. Any amendment or waiver effected in accordance with this Section 6.7 shall be binding upon each holder of any Securities purchased under this Agreement at the time
outstanding (including Securities into which such Securities are convertible), each future holder of all such Securities and the Company. 
 6.9 Severability. If one or more provisions of this Agreement are held to be unenforceable under applicable law, such provision shall be excluded from this Agreement and the balance of the Agreement shall be
interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms. 
 6.10 Entire
Agreement. This Agreement and the documents referred to herein constitute the entire agreement among the parties, and this Agreement supersedes all prior written and oral agreements, and all contemporaneous oral agreements, relating to the
subject matter hereof. 
  

 11 

 6.11 Counterparts; Facsimile Signatures. This Agreement may be executed in two or
more counterparts, and by facsimile signatures, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 [SIGNATURE PAGE FOLLOWS] 
  

 12 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written.

  

			
	COMPANY:
	
	 INSERT THERAPEUTICS, INC.
 a Delaware corporation

		
	 By:
	 	 /s/ John G. Petrovich

		 	 John G. Petrovich

		 	 President

			
		
	 Address:
	 	 129 North Hill Ave.
 Pasadena, CA 91106

 [SIGNATURE PAGE TO SUBSCRIPTION AGREEMENT] 

 [Purchaser Signature Page to Subscription and Purchase Agreement] 
 I HEREBY REPRESENT THAT I HAVE READ AND UNDERSTOOD THE SUBSCRIPTION AGREEMENT. 
 Subscription: I hereby subscribe for the following number of Units at the Purchase Price indicated: 
 Dated:             , 2006 
 Total Purchase Price:              
 Total Units ($1.00/Unit): 
 _____________________________________________________ 
 Please print the exact name(s) in which the shares should be held:

			
	
		
	 Print Name:
	 	  
	 Signature:
	 	  
	 Social Security # or Tax Id#:
	 	  
	 Address:
	 	  
		 	  
	 City, State & Zip:
	 	  
	 Phone:
	 	  
	 Facsimile:
	 	  
	 Email:
	 	  

 [SIGNATURE PAGE TO SUBSCRIPTION AGREEMENT] 

 SCHEDULE A 
 SCHEDULE OF EXCEPTIONS 
 The following are the exceptions of Insert Therapeutics, Inc. (the
“Company”) to the representations and warranties as set forth in that certain Subscription Agreement (the “Agreement”) dated as of September     , 2006. The section numbers
in this Schedule of Exceptions correspond to section numbers in the Agreement. Disclosure of any matters in this Schedule of Exceptions does not constitute an admission that such matter is necessarily required to be disclosed in order for any
representation or warranty in the Agreement to be true and correct to the extent required in the Agreement. Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Agreement. 
 Section 2.12(b) 
 Convertible
Promissory Notes, dated as of April 28, 2006, May 26, 2006, July 20, 2006, August 2, 2006 and Aug 24, 2006, issued to Arrowhead Research Corporation in the aggregate principal amount of $2,000,000. 
 Section 2.12(b) 
 License Agreement with Calando Pharmaceuticals, Inc. dated as of March 14, 2005, as amended. 
 Section 2.12(c) 
 License Agreement with Calando Pharmaceuticals, Inc. dated as of March 14, 2005,
as amended. 

 EXHIBIT A 
 SECOND AMENDED AND RESTATED CERTIFICATE OF INCORPORATION 

 EXHIBIT B 
 JOINDER AGREEMENT 

 EXHIBIT C 
 INVESTORS’ RIGHTS AGREEMENT AMENDMENTForm of Warrant

 Exhibit 10.2 
 NEITHER THIS WARRANT, THE SERIES D PREFERRED STOCK ISSUABLE UPON THE EXERCISE HEREOF, NOR THE COMMON STOCK ISSUABLE UPON CONVERSION OF THE SERIES D PREFERRED STOCK, HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO THE SECURITIES UNDER SUCH ACT OR AN
OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED OR UNLESS SOLD PURSUANT TO AN EXEMPTION TO SUCH ACT. 
  

			
	 No-            
	  	Void after             , 2016

 WARRANT TO PURCHASE SHARES 
 OF 
 SERIES D PREFERRED STOCK 
 OF 
 INSERT THERAPEUTICS, INC., 
 A Delaware corporation 
 This certifies that, for value received, the Holder identified
as such on the signature page hereof (together with its successors and assigns) is entitled to subscribe for and purchase, on the terms hereof, shares of Series D Preferred Stock, $0.0001 par value (the “Series D Preferred
Stock”) of Insert Therapeutics, Inc., a Delaware corporation (the “Company”), subject to adjustment as provided herein. 
 This Warrant is subject to the following terms and conditions: 
 1. Exercise of Warrant. The terms
and conditions upon which this Warrant may be exercised, and the shares of Series D Preferred Stock subject hereto may be purchased, are as follows: 
 1.1 Term. Subject to the terms hereof, this Warrant may be exercised at any time after the date hereof, or from time to time, in whole or in part; provided, however, that in no event may this Warrant be
exercised later than 5:00 p.m. (Pacific Time) on [            , 2008], on which date this Warrant will expire (the “Expiration Date”) 
 1.2 Number of Shares. This Warrant may initially be exercised to purchase up to an aggregate of
            shares of Series D Preferred Stock (the “Number of Shares”), subject to adjustment as provided herein. 
 1.3 Exercise Price. The exercise price per share for all shares of Series D Preferred Stock to be issued upon exercise of this
Warrant shall be $1.25 (the “Exercise Price”), subject to adjustment as provided herein. 
 1.4 Method of
Exercise. The exercise of the purchase rights evidenced by this Warrant shall be effected by (a) the surrender of the Warrant, together with a duly executed copy of the form of Subscription Notice attached hereto as Schedule 1, to the
Company at its principal offices and (b) the delivery of the exercise price by check or bank draft payable to the Company’s order or by wire transfer to the Company’s account for the number of shares for which the purchase rights
hereunder are being exercised or any other form of consideration approved by the Company’s Board of Directors (the “Board”). Each exercise of this Warrant shall be deemed to have been effected immediately prior to the
close of business on the day on which this Warrant shall have been surrendered to the Company as 

  

 W-1 

 
provided herein or at such later date as may be specified in the executed form of subscription (or as determined pursuant to Section 3), and at such
time the person or persons in whose name or names any certificate or certificates for shares of Series D Preferred Stock shall be issuable upon such exercise as provided herein shall be deemed to have become the holder or holders of record thereof.

 2. Adjustments. 
 2.1 Stock Splits and Reverse Splits. If at any time the outstanding shares of Common Stock of the Company (the “Common Stock”) or any series of Preferred Stock of the Company (the
“Preferred Stock”) are subdivided into a greater number of shares, then the Exercise Price will be reduced proportionately and the Number of Shares will be increased proportionately. Conversely, if at any time the outstanding shares
of Common Stock or any series of Preferred Stock are consolidated into a smaller number of shares, then the Exercise Price will be increased proportionately and the Number of Shares will be reduced proportionately. 
 2.2 Dividends. In the event the Company declares a dividend upon the Common Stock or upon any series of Preferred Stock, whether in
cash, property or securities, at the time of subsequent exercise of this Warrant, the Company shall deliver both (i) the Number of Shares for which exercise is made plus (ii) such cash, property or securities paid as dividends as would
have been previously distributed to the Holder if such exercise had been made prior to such earlier exercise. If the Company shall declare a dividend payable in cash on its Common Stock or Preferred Stock and shall at substantially the same time
offer to its stockholders a right to purchase new equity or an equity equivalent from the proceeds of such dividend, or for an amount substantially equal to the dividend, the amount of equity so offered shall, for the purpose of this Warrant, be
deemed to have been issued as a stock dividend. 
 2.3 Effect of Reorganization. If any (i) reorganization or
reclassification of the Common Stock or Preferred Stock, (ii) consolidation or merger of the Company with or into another corporation, (iii) sale of all or substantially all of its operating assets to another corporation, or (iv) sale
of the Company substantially as a going concern followed by a liquidation of the Company (any such occurrence, other than a “Change of Control” as defined below, shall be an “Event”), is effected in such a way that holders
of Common Stock or Preferred Stock are entitled to receive securities and/or assets as a result of their Common Stock or Preferred Stock ownership, then upon exercise of this Warrant the Holder will have the right to receive the shares of stock,
securities or assets which they would have received if such rights had been fully exercised as of the record date for such Event. The Company will not effect any Event unless prior to or simultaneously with its consummation the successor corporation
resulting from the consolidation or merger (if other than the Company), or the corporation purchasing the Company’s assets, assumes the performance of the Company’s obligations under this Warrant (as appropriately adjusted to reflect such
consolidation, merger or sale such that the Holder’s rights under this Warrant remain, as nearly as practicable, unchanged) by a binding written instrument. In the event of a Change in Control, Section 3 shall control the treatment of this
Warrant and this Section 2.3 will not apply. 
 2.4 Other Securities Adjustments. If as a result of this
Section 2, a Holder is entitled to receive any securities other than Series D Preferred Stock upon exercise of this Warrant, the number and purchase price of such securities shall thereafter be adjusted from time to time in the same manner as
provided pursuant to this Section 2. The allocation of purchase price between various securities shall be made in writing by the Company’s Board in good faith at the time of the event by which the Holder becomes entitled to receive new
securities, and a copy sent to the Holder. 
 2.5 Notice of Adjustments and Record Dates. The Company shall promptly
notify the Holder in writing of each adjustment or readjustment of the exercise price hereunder and the number 

  

 W-2 

 
of shares of Series D Preferred Stock (or any shares of stock or other securities which may be) issuable upon the exercise of this Warrant. Such notice shall
state the adjustment or readjustment and show in reasonable detail the facts on which that adjustment or readjustment is based. 
 2.6 No Impairment. The Company shall not avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but shall at all times in good faith assist in the carrying out
of all the provisions of this Warrant. Without limiting the generality of the foregoing, the Company (a) shall at all times reserve and keep available a number of its authorized shares of Series D Preferred Stock, free from all preemptive
rights therein, which shall be sufficient to permit the exercise of this Warrant, (b) shall take all such action as may be necessary or appropriate in order that all shares of Series D Preferred Stock as may be issued pursuant to the exercise
of this Warrant shall, upon issuance, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to the issue thereof, (c) shall at all times reserve and keep available a number of its
authorized shares of Common Stock, free from all preemptive rights therein, which shall be sufficient to permit the conversion of the Series D Preferred Stock, and (d) shall take all such action as may be necessary or appropriate in order that
all shares of Common Stock as may be issued pursuant to the conversion of the Series D Preferred Stock shall, upon issuance, be duly and validly issued, fully paid and nonassessable and free from all taxes, liens and charges with respect to the
issue thereof. 
 3. Change in Control. 
 (a) If at any time the Company engages in a Change of Control (as defined below), then as a part of such Change of Control, this Warrant shall be deemed automatically exercised immediately prior to such Change of
Control and Holder shall be entitled to receive consideration in the Change of Control based upon the number of shares of Series D Preferred Stock (or any shares of stock or other securities which may be) issuable upon exercise of the Warrant, less
the product of (1) the number of shares of Series D Preferred Stock and (2) the Exercise Price. 
 (i)
“Affiliate” means, with respect to any specified Person, any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified Person. For purposes of this
definition, “control” (including, with correlative meanings, the terms “controlling,” “controlled by” and “under common control with”), as used with respect to any specified Person, shall mean the possession,
directly or indirectly, of the power to direct or cause the direction of the management or policies of such Person, whether through the ownership of voting securities, by agreement or otherwise. 
 (ii) “Change of Control” means the occurrence of any of the following: (a) the sale, lease, transfer,
conveyance or other disposition (other than by way of merger or consolidation), in one or more related transactions, of all or substantially all of the properties and assets of the Company and its subsidiaries taken as a whole to any
“person” (as such term is used in Section 13(d)(3) of the Exchange Act), other than Arrowhead Research Corporation (“Arrowhead”) and its Affiliates, (b) the adoption of a plan relating to the liquidation
or dissolution of the Company, (c) the consummation of any transaction or other event (including, without limitation, any merger or consolidation) the result of which is that Arrowhead and its Affiliates own less than 50% of the voting stock of
the Company, or (d) the first day on which a majority of the members of the Board are not continuing directors on the Board. 
 (iii) “Person” means any individual, corporation, partnership, joint venture, association, joint-stock company, limited liability company, trust, unincorporated organization or government or agency or political
subdivision thereof (including any subdivision or ongoing business of any such entity or substantially all of the assets of any such entity, subdivision or business). 
  

 W-3 

 4. Redemption of Warrants. This Warrant is subject to redemption by the Company, in whole but not
in part, at a redemption price of $0.0001 per share, at any time after July 1, 2007 and prior to the Expiration Date, on not less than 30 days prior written notice to the Holder. The Holder shall have the right to exercise the Warrant for cash,
in whole or in part, before the date specified in the redemption notice. Upon expiration of such period, all rights of the Holder shall terminate, other than the rights to receive the redemption price, without interest, and the right to receive the
redemption price shall itself expire on the Expiration Date. 
 5. Replacement of Warrants. On receipt by the Company of evidence
reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of any such loss, theft or destruction of this Warrant, on delivery of an indemnity agreement reasonably satisfactory in form and
amount to the Company or, in the case of any such mutilation, on surrender and cancellation of such Warrant, the Company at its expense shall execute and deliver to the Holder, in lieu thereof, a new Warrant of like tenor. 
 6. Investment Intent. Unless a current registration statement under the Securities Act of 1933, as amended, shall be in effect with respect to the
securities to be issued upon exercise of this Warrant, the Holder, by accepting this Warrant, covenants and agrees that, at the time of exercise hereof, and at the time of any proposed transfer of any securities acquired upon exercise hereof, the
Holder shall deliver to the Company a written statement that the securities acquired by the Holder upon exercise hereof are for the own account of the Holder for investment and are not acquired with a view to, or for sale in connection with, any
distribution thereof (or any portion thereof) and with no present intention (at any such time) of offering or distributing such securities (or any portion thereof). 
 7. Restrictive Legend. The Series D Preferred Stock (or any shares of stock or other securities which may be) issuable upon exercise of the Warrant (unless registered under the Act) shall be stamped or
imprinted with a legend in substantially the following form: 
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”) OR QUALIFIED UNDER APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE SOLD OR OTHERWISE TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION AND QUALIFICATION OR THE DELIVERY TO THE COMPANY OF A
SIGNED OPINION OF COUNSEL FOR HOLDER SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION ARE NOT REQUIRED UNLESS SOLD PURSUANT TO RULE 144 OF THE ACT. 
 8. Restrictions. Upon Transfer and Removal of Legend. The Company need not register a transfer of this Warrant, the Series D Preferred Stock (or any shares of stock or other securities) arising from exercise of
this Warrant bearing the restrictive legend set forth in Section 7 hereof, unless the conditions specified in such legend are satisfied; provided however, that such conditions shall be deemed to be satisfied with respect to a transfer without
consideration by any holder (i) to an affiliate of such holder, (ii) if such holder is a partnership, to a partner or retired partner of such partnership who retires after the date hereof or to the estate of any such partner or retired
partner, (iii) if such holder is a 

  

 W-4 

 
corporation, to a shareholder of such corporation, or to any other corporation under common control, direct or indirect, with such holder, (iv) if such
holder is a limited liability company, to a member of such limited liability company, or (v) by gift, will or intestate succession of any individual holder to his spouse or siblings, or the lineal descendants or ancestors of such holder or his
spouse, if the transferee agrees in writing to be subject to the terms hereof to the same extent as if such transferee were the original Holder hereunder, or if such transfer is exempt from registration under Rule 144 issued under the Act.

 9. No Rights or Liability as a Stockholder. This Warrant does not entitle the Holder hereof to any voting rights or other rights as
a stockholder of the Company. No provisions hereof, in the absence of affirmative action by the Holder to purchase Series D Preferred Stock, and no enumeration herein of the rights or privileges of the Holder, shall give rise to any liability of the
Holder as a stockholder of the Company. 
 10. Miscellaneous. 
 10.1 Titles and Subtitles. The titles and subtitles used in this Warrant are for convenience only and are not to be considered in
construing or interpreting this Warrant. 
 10.2 Notices. Any notice required or permitted under this Warrant shall be
given in writing to the respective addresses of the Holder and the Company set forth on the signature page hereof, or to such other address as either party shall designate in a written notice given to the other as provided herein. 
 10.3 Attorneys’ Fees. If any action at law or in equity is necessary to enforce or interpret the terms of this Warrant, the
prevailing party shall be entitled to reasonable attorneys’ fees, costs and disbursements in addition to any other relief to which such party may be entitled. 
 10.4 Amendments and Waivers. Any term of this Warrant may be amended and the observance of any term of this Warrant may be waived
(either generally or in a particular instance and either retroactively or prospectively), as provided in the Purchase Agreement. 
 10.5 Assignment and Transferability. Except as provided in Section 8 of this Warrant, this Warrant may be assigned or transferred by the Holder only with the prior written approval of the Company, in its sole and absolute
discretion. This Warrant shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. 
 10.6 Severability. If one or more provisions of this Warrant are held to be unenforceable under applicable law, such provision
shall be excluded from this Warrant and the balance of the Warrant shall be interpreted as if such provision were so excluded and shall be enforceable in accordance with its terms. 
 10.7 Governing Law. This Warrant shall be governed by and construed and enforced in accordance with the laws of the State of
California, without giving effect to its conflicts of laws principles. 
 10.8 Counterparts. This Warrant may be
executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
 [Remainder of the page intentionally left blank] 
  

 W-5 

 [Signature Page to Warrant Shares of Series D Preferred Stock] 
 IN WITNESS WHEREOF, the parties hereto have caused this Warrant to be duly executed as of the date hereof. 
 Dated as of:             , 2006 
  

					
		 	“Company”
		
		 	 INSERT THERAPEUTICS, INC.
 129 N. Hill Ave., Suite 104
 Pasadena, CA 91106

		
	 By:
	 	 /s/ John G. Petrovich

		 	 John G. Petrovich, President

  

	
	 “Holder”

	
	 ACKNOWLEDGED AND AGREED:

	
	   
	(Signature)
	  
	(Print Name)
	 Address:

	  
	  
	  

  

 W-6 

 SCHEDULE 1 
 EXERCISE NOTICE 
 (To be signed only on exercise of Warrant for cash) 
  

	To:	INSERT THERAPEUTICS, INC: 

 The undersigned, the holder of
the Warrant attached hereto, hereby irrevocably elects to exercise the purchase rights represented by such Warrant for, and to purchase thereunder,             shares of the Series D
Preferred Stock of Insert Therapeutics, Inc., a Delaware corporation, and herewith makes payment of $            therefor, and requests that the certificates for such shares be
issued in the name of, and delivered to             , whose address is             . 
 _____________________________________________. 
  ______________________________________ 
  (Signature must conform in all respects to name of 
  the Holder as specified on the face of the
Warrant) 
  

			
	  ____________________________________
	 	 (Print Name)

		
	  ____________________________________
	 	 (Address)

 Dated:
                             
  

 Schedule 1-1

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