Document:

Amendment No. 1 to Yellow Corporation Pension Plan

 Exhibit 10.2 
  
 AMENDMENT NO. 1 TO 
  
 YELLOW CORPORATION PENSION PLAN 
  
 As amended and restated January 1, 2004 
  
 WHEREAS, Yellow Roadway Corporation (the “Company”) previously adopted the Yellow Corporation Pension Plan, as amended and
restated January 1, 2004 (the “Plan”); 
  
 WHEREAS, the Plan allows benefit distributions in the form of annuities and in Section 5.1(h) provides for retroactive payments when benefit payments commence after a participant’s annuity starting date; 
  
 WHEREAS, the Internal Revenue Service has issued guidance that
requires the amendment of the Plan to include additional provisions with respect to the retroactive annuity starting date; 
  
 NOW, THEREFORE, BE IT RESOLVED, that the Plan shall be amended as stated below: 
  
 “THIS AMENDMENT, effective as of January 1, 2004, is made and entered into by Yellow Roadway
Corporation to amend the Yellow Corporation Pension Plan, as amended and restated January 1, 2004, as follows: 
  

	1.	Section 5.1(c) is amended to read in its entirety as follows: 

  

	 	“(c)	At the time prescribed in Section 5.1(f) below with respect to the Participant’s annuity starting date (i.e., the first date on which an amount is paid or payable
as an annuity or any other form), if a proper election is made as provided below, in lieu of the 50% Joint and Survivor Annuity, a Participant and his Eligible Spouse may elect in writing to receive the Participant’s Pension in the form of a
single life Pension based on the Participant’s life as provided in Article IV or, if eligible, may elect an optional form of Pension under Section 5.3.” 

  

	2.	Sections 5.1(e) through (h) are deleted and the following provisions are added: 

  

	 	“(e)	For purposes of Section 401(a)(11) of the Code, the Pensions for both married and unmarried Participants, described herein (other than certain of the optional forms under
Section 5.3) are qualified joint and survivor annuities. Any Pension herein which provides an annuity for the life of the Eligible Spouse which is not less than 50 percent and not more than 100 percent of the amount of the annuity which is
payable during the joint lives of the Participant and the Eligible Spouse, is a qualified joint and survivor annuity. 

  

	 	(f)	The Administrative Committee shall provide to each Participant a written explanation of (i) the terms and conditions of the qualified joint and survivor annuity and each
optional form of Pension and (ii) the relative values of the various optional forms of benefits available under the Plan, (iii) the Participant’s right to make, and the effect of, an election to waive the qualified joint and survivor
annuity form of Pension, (iv) the rights of the Participant’s Eligible Spouse to receive the benefit and (v) the right to make, and the effect of, a revocation of an election to waive the qualified joint and survivor annuity form of
Pension by electing a different form of Pension. The written explanation shall clearly state that the Participant has at least 30 days in which to consider whether to waive the joint and survivor annuity and elect another form of Pension. The
written explanation shall be provided to each Participant at the following time: 

	 	(i)	in the case of an explanation provided to a Participant prior to his annuity starting date, not more than 90, and not less than 30, days prior to the Participant’s annuity
starting date, or 

  

	 	(ii)	in the case of an explanation provided to a Participant after his annuity starting date, not more than 90, and not less than 30, days prior to the date on which the
Participant’s Pension payments commence. 

  

	 	(g)	A Participant may elect to waive the 30-day notice period described in Section 5.1(f) above; provided, however, that the commencement of the Participant’s Pension
payments shall not be earlier than the expiration of the 7-day period beginning on the day after the date the written explanation is provided to the Participant. 

  

	 	(h)	Upon the Participant’s receipt of the written explanation described in Section 5.1(f) above, the Participant may elect in writing during the period described in
Section 5.1(i) below, to waive the qualified joint and survivor annuity and elect an optional form of Pension, provided that the Participant’s Eligible Spouse consents to such election or the Participant establishes to the satisfaction of
the Administrative Committee that the Eligible Spouse’s consent cannot be obtained because (i) there is no Eligible Spouse, (ii) the Eligible Spouse cannot be located or (iii) of such other circumstances as the Secretary of the
Treasury may by regulations prescribe. 

  

	 	(i)	A Participant may make or may revoke his election not to take a qualified joint and survivor annuity pursuant to the written explanation described in Section 5.1(f) at any time
and any number of times after receiving the written explanation and prior to: 

  

	 	(i)	in the case of a written explanation provided to the Participant prior to his annuity starting date, the later of his annuity starting date or the last day of the 7-day period, or

  

	 	(ii)	in the case of a written explanation provided to the Participant after his annuity starting date, the last day of the 30-day period described in Section 5.1(f) above or the
last day of the 7-day period, whichever is applicable. 

  

	 	(j)	An Eligible Spouse may not revoke his or her consent waiving the right to receive the Pension in the form of a qualified joint and survivor annuity. 

  

	 	(k)	If the Administrative Committee provides the written explanation required by Section 5.1(f) above to a Participant prior to his annuity starting date, the Participant may elect
an annuity starting date that is the first day of any calendar month after the written explanation is provided to him; provided, however, that the commencement of the Participant’s Pension payments is not more than 90 days after the date
the written explanation is provided. This 90-day requirement will not be violated if the commencement of the Participant’s Pension payments is more than 90 days after the date the written explanation is provided if the delay is solely on
account of an administrative delay. 

  

	 	(l)	If the Administrative Committee provides the written explanation required by Section 5.1(f) to a Participant after his annuity starting date, the rules in this
Section 5.1(l) shall apply notwithstanding anything in the Plan to the contrary. 

	 	(i)	The Participant may elect a date for the commencement of his Pension payment that is after the Participant’s annuity starting date only if all of the following requirements are
satisfied: 

  

	 	(A)	The Participant affirmatively elects an annuity starting date that is the first day of any calendar month before the date the written explanation is provided to the Participant,
provided that the annuity starting date elected by the Participant shall not be prior to the date on which the Participant otherwise could have first started receiving a Pension under the terms of the Plan (as the Plan is in effect on the
Participant’s annuity starting date). 

  

	 	(B)	The commencement of the Participant’s Pension payments is not more than 90 days after the Participant is provided the written explanation; provided, however, that such
90-day requirement will not be violated if the commencement of the Participant’s Pension payments is more than 90 days after the date the written explanation is provided if the delay is solely on account of an administrative delay.

  

	 	(C)	Subject to any adjustment as may be required to comply with clause (F) below, the Plan pays the Participant a make-up payment in an amount equal to the aggregate amount of any
missed payment(s) during the period from the Participant’s annuity starting date to the date of such make-up payment, plus interest as required at a reasonable rate or, if applicable, at the rate specified by the Code or the Treasury
regulations, from the date(s) the missed payment(s) would have been made to the date of the actual make-up payment. 

  

	 	(D)	Subject to any adjustment as may be required to comply with clause (F) below, periodic payments to the Participant on and after the date of the commencement of the
Participant’s Pension payments are the same as the periodic payments that would have been paid to the Participant on and after his annuity starting date had the Participant’s benefit payments actually commenced on his annuity starting
date. 

  

	 	(E)	The Participant’s Eligible Spouse (including an alternate payee under a Qualified Domestic Relations Order, as defined in Section 414(p) of the Code) grants consent to the
distribution; provided, however, that the Eligible Spouse’s consent under this clause (E) shall not be required if the amount of the Eligible Spouse’s survivor annuity payments under the Participant’s elected form of
Pension benefit is not less than the amount the Eligible Spouse’s survivor annuity payments would have been under the qualified joint and survivor annuity with an annuity starting date after the date the written explanation is provided.

  

	 	(F)	 The distribution commencing on the date of commencement of the Participant’s Pension payments, as adjusted for interest, satisfies the requirements of
Section 415 of the Code applied as if the date of commencement of the Participant’s Pension payments was, for all purposes under Section 415 of the Code, 

	 	 
including determining the applicable interest rate and the applicable mortality table, the Participant’s annuity starting date; provided, however,
that this clause (F) shall not apply to any Pension benefit payable in the form of an annuity if the date of commencement of the Participant’s Pension payments is 12 months or less from his annuity starting date.

  

	 	(G)	The Pension benefit determined as of the Participant’s annuity starting date satisfies the requirements of Section 415 of the Code, with the applicable interest rate and
the applicable mortality determined as of the date of the commencement of the Participant’s Pension payments. 

  

	 	(H)	The form of Pension is not subject to Code Section 417(e)(3). 

  

	 	(ii)	If an individual is a former spouse of the Participant and is not the Eligible Spouse on the Participant’s annuity starting date, then, unless otherwise provided by a Qualified
Domestic Relations Order, as defined in Section 414(p) of the Code, the consent of such individual will not be required under Section 5.1(h) for the Participant to elect to have his Pension benefit paid in a form other than the joint and
survivor annuity. 

  

	 	(iii)	This Section 5.1(l) shall become effective as of January 1, 2004, except that the last sentence of Section 5.1(l)(i)(A) and Section 5.1
(l)(i)(H) shall become effective as of December 16, 2005. 

  

	2.	The cross-references of the Plan be redesignated, as necessary, for the revisions in paragraph 1. 

  

	3.	Except as otherwise amended by this Amendment No. 1, all provisions of the Plan shall remain in full force and effect. 

  
 IN WITNESS WHEREOF, the Company has caused this instrument to be
executed by its duly authorized officers as of the 15th day of September 2005. 
  

			
	 YELLOW ROADWAY CORPORATION
	 	 
		
	 	 	 /s/ Harold D. Marshall

	 	 	 Harold D. Marshall

	 	 	Vice President – Employment BenefitsAmendment No. 1 to Exclusive Sales Distribution Agreement

 
CONFIDENTIAL 
  
 Exhibit 10.1 
  
 AMENDMENT NO. 1 
 TO
EXCLUSIVE SALES DISTRIBUTION AGREEMENT 
  
 THIS AMENDMENT
NO. 1 (“Amendment”) to that certain Exclusive Sales Distribution Agreement, dated July 1, 2004 (“Agreement”), is dated September 30, 2005 (“Amendment Effective Date”), and is between Orthovita, Inc., a
Pennsylvania corporation with principal offices at 45 Great Valley Parkway, Malvern, Pennsylvania 19355 (“Orthovita”), and Angiotech BioMaterials Corp. (formerly known as Cohesion Technologies, Inc.), a Delaware corporation with principal
offices at 2500 Faber Place, Palo Alto, California 94303 (“Cohesion”). 
  
 RECITALS 
  
 WHEREAS,
Orthovita and Cohesion have previously entered into the Agreement; 
  
 WHEREAS, Orthovita and Cohesion are in the process of transitioning manufacturing of Products and Accessories (both as defined in the Agreement) from Cohesion to Orthovita, and by this Amendment Orthovita and Cohesion wish to set forth
certain understandings and acknowledgements regarding Cohesion’s supply of Products and Accessories to Orthovita before November 1, 2005, and to make certain additional modifications to the Agreement, all as set forth below; 
  
 WHEREAS, Orthovita and Cohesion are negotiating a new license agreement
(“License Agreement”) in connection with Orthovita’s assumption of responsibility for manufacturing of Products and Accessories; and 
  
 WHEREAS, Orthovita and Cohesion desire that all other terms and conditions of the Agreement remain in full force and effect; 
  
 NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Orthovita and Cohesion hereby agree to amend the Agreement by and in accordance with this Amendment as follows: 
  
 1.       Definitions; References. Capitalized terms in this Amendment shall have the same meaning as those in the Agreement, unless
specifically defined otherwise in this Amendment. All Article and Section references shall refer to the corresponding Article and Section in the Agreement, unless specifically stated to refer to an Article or Section of this Amendment. 

 

	2.	Amendments. 

  
 2.1    Amendment to Section 5.1. Section 5.1 is hereby amended and restated in its entirety as follows: 

 

	 	“5.1	 As of the Effective Date, Cohesion and Orthovita planned to form three (3) committees – the “Joint Sales and Marketing Committee,” the
“Joint Clinical Development Committee,” and the “Joint Commercial Operations Committee.” However, the Parties have agreed instead to form one “Joint 

  

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Committee,” which shall fulfill the responsibilities of each of the originally planned three (3) committees, and each Party has designated its
program director (“Program Director”). The Joint Committee shall consist of up to three (3) representatives from each Party, one of which shall be each Party’s Program Director, for a total of up to six (6) Joint Committee
members. Cohesion and Orthovita shall each retain the right to change its representative(s) to the Joint Committee, including its Program Director, from time to time, upon written notice to the other Party, or to appoint one or more substitutes to
serve in the place of an absent member(s). The Program Directors also shall serve as co-chairs of the Joint Committee (each a “Co-Chair”). The Joint Committee representatives of Cohesion and Orthovita shall be employees that agree to be
bound by the terms of confidentiality and other pertinent provisions of this Agreement. Each Joint Committee member, including the Program Directors, shall have expertise in a relevant discipline, such as business development, research and
development, clinical and/or regulatory affairs, sales or marketing. All committee obligations set forth in Sections 5.2 through 5.4 shall remain in full force and effect, and all references in this Agreement to one of the originally planned three
(3) committees shall be deemed to refer instead to the Joint Committee.” 

  
 2.2     Amendment to Section 5.5. Section 5.5 is hereby amended and restated in its entirety as follows: 

 

	 	“5.5	The Joint Committee shall hold meetings at approximately three month intervals (at mutually agreed times), or more frequently as necessary or upon prior request by a Program
Director. Meetings of the Joint Committee will be held in person at alternating locations of the respective Co-Chair’s choosing, or by teleconference or videoconference at the respective Co-Chair’s discretion. The initial meeting of the
new Joint Committee is expected to be held during the fourth calendar quarter of 2005 to finalize transition of manufacturing from Cohesion to Orthovita, to discuss sale of Cohesion equipment to Orthovita and to address such other matters as are
deemed relevant by either Cohesion or Orthovita, and will be initiated by the Orthovita Co-Chair. Other employees of each Party involved in the development, manufacture and/or commercialization of a Product and/or an Accessory may attend such
meetings as nonvoting participants, and, with the consent of each Party, consultants, representatives, or advisors involved in the development, manufacture and/or commercialization of a Product and/or an Accessory may attend such meetings as
nonvoting observers; provided that such third party representatives are under obligations of confidentiality and non-use applicable to the Confidential Information of each Party that are at least as stringent as those set forth in this Agreement.
Each Party shall be responsible for all of its own expenses of participating in a Joint Committee meeting.” 

  

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CONFIDENTIAL 
  
  
 2.3     Amendment to
Section 6.2. Section 6.2 is hereby amended and restated in its entirety as follows: 
  

	 	“6.2	In addition to the CoStasis Price, Orthovita shall pay to Cohesion royalties as a percentage of total Net Sales for each Calendar Year on a quarterly basis, in each of **** (as
applicable), at the royalty rates set forth in Exhibit E, and subject to the provisions of this Section 6.2. All such royalty payments shall be made by Orthovita within thirty (30) days following the end of the calendar quarter in
which such sales were made and for which such royalty payment is due, and shall be accompanied by the quarterly sales report set forth in Section 6.3. Total Net Sales shall be determined for each Calendar Year of the Term and for each of ****
(as applicable), and Net Sales made in one Calendar Year shall not count toward the total Net Sales in any other Calendar Year. For purposes of this Agreement, Orthovita shall account for sales of CoStasis Products (whether manufactured by Cohesion
or by or on behalf of Orthovita) on a first-in, first-out basis. The Parties acknowledge and agree that, as of the Amendment Effective Date, Orthovita has paid royalties at the royalty rates set forth in Exhibit E on Net Sales of the number
of units of CoStasis Products as set forth on Exhibit H, Column A. Orthovita and Cohesion agree that, after the Amendment Effective Date, Orthovita shall be required to pay royalties at the royalty rates set forth in Exhibit E on Net Sales of
CoStasis Products up to that number of units of CoStasis Products set forth on Exhibit H, Column B, and thereafter, notwithstanding Exhibit E, Orthovita shall pay royalties at a rate of **** of Net Sales on sales of units of CoStasis
Products up to that number of units of CoStasis Products set forth on Exhibit H, Column C. For the avoidance of doubt, WIP (as defined below) that is purchased by Orthovita and is converted into final finished CoStasis Product by or on behalf
of Orthovita after the Amendment Effective Date shall be subject to the royalty and other relevant provisions of this Agreement as if such product had been sold by Cohesion to Orthovita in finished form.” 

  
 2.4     Amendment to Section 6.4.
Section 6.4 is hereby amended and restated in its entirety as follows: 
  

	 	“6.4	 Within thirty (30) days after the Effective Date, and subject to satisfactory inspection by Orthovita representatives, which shall not be unreasonably
withheld, Orthovita shall pay to Cohesion **** to purchase Cohesion’s existing inventory of Accessories, as listed in Exhibit B. Within ninety (90) days after receipt of such payment, Cohesion shall deliver to Orthovita such
Accessories in accordance with instructions provided by Orthovita and with Sections 6.11 and 6.12. In addition, Cohesion may sell to Orthovita additional Accessories at the prices set forth in Amended Exhibit F; provided that all such
additional Accessories sold to Orthovita by Cohesion shall be treated under Sections 6.8 through 6.10 as if such additional Accessories were “Products.” For the sake of clarity, Orthovita 

  

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shall have no obligation to pay royalties on any Accessories purchased from Cohesion under this Agreement or this Amendment. If a further supply of
Accessories is needed by Orthovita after the Amendment Effective Date, Cohesion shall provide Orthovita with Accessory specifications and contact information for third party Accessory suppliers and/or manufacturers previously used by Cohesion to
obtain Accessories, as listed in Exhibit B. Orthovita shall be responsible for negotiating with such suppliers and/or manufacturers, or other suppliers or manufacturers of Orthovita’s choosing, to obtain Accessories. Upon
Orthovita’s written request, Cohesion shall provide reasonable assistance to Orthovita in securing an ongoing supply of Accessories, including making introductions to Accessory suppliers and/or manufacturers previously used by Cohesion and
providing specifications for the Accessories. Upon execution of this Amendment by Orthovita, the numbers of Products and Accessories set forth in Exhibit G shall be deemed to constitute a firm and binding Purchase Order by Orthovita for such
numbers of Products and Accessories.” 

  
 2.5     Amendment to Section 6.15. The first paragraph of Section 6.15 is hereby amended and restated in its entirety as follows: 
  

	 	“6.15	The Parties contemplate that during the Term, Cohesion will transfer manufacturing of one or more Products and Accessories to Orthovita or to one or more third party manufacturers,
as set forth in this Section 6.15 of the Agreement or in Section 3.1 of the Amendment.” 

  
 2.6     Amendment to Exhibit F. Exhibit F is hereby deleted in its entirety, and the attached Amended Exhibit F
is hereby substituted therefor. For purposes of this Amendment, the Parties hereby waive the provisions of Section 6.5 with respect to any price changes set forth in Amended Exhibit F. 
  

	3.	Additional Agreements. 

  
 3.1     Supply of Products and Accessories through October 31, 2005; Manufacturing Technology Transfer; Indemnification.

  
         (a)         The Parties further acknowledge and agree that they are in the process of transitioning manufacturing of Products and Accessories to
Orthovita. Orthovita acknowledges and agrees that Cohesion shall close its manufacturing facility no later than **** (the “Closing Date”). Orthovita shall purchase from Cohesion, prior to or as of the Closing Date, the total number of
Products and Accessories set forth in Exhibit G, as well as all the Product-related work-in-process set forth in Exhibit G (such work-in-process referred to hereinafter as the “WIP”). Amended Exhibit F sets forth the
total number of items of each Product, Accessory and WIP that have been or will be supplied by Cohesion to Orthovita between the Effective Date of the Agreement and the Closing Date; Exhibit G sets forth the number of items of each Product,
Accessory and WIP set forth in Amended Exhibit F that has not been supplied to Orthovita as of the 

  

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CONFIDENTIAL 
  
  
 
Amendment Effective Date, but that will be supplied to Orthovita prior to or as of the Closing Date. The number of items of Products, Accessories and WIP set
forth in Exhibit G shall be deemed to constitute a binding Purchase Order of Orthovita, and prior to the Closing Date Orthovita shall, subject to Section 6.12, purchase from Cohesion all such Products, Accessories and WIP set forth in
Exhibit G, at the respective prices set forth in Exhibit G; provided that such Products and Accessories provided by Cohesion shall conform to the Product specifications and regulatory requirements as of date of receipt by Orthovita,
and such WIP shall conform to Product specifications that are relevant to the stage of manufacture of the WIP as of date of receipt by Orthovita. 
  
         (b)         After Cohesion has supplied to
Orthovita the total number of units of a given Product, Accessory or WIP at the “Price A” specified in Amended Exhibit F (wherein counting of such total number of units shall start as of the Effective Date), all subsequent units of
such Product or Accessory provided by Cohesion shall be supplied at the “Price B” specified in Amended Exhibit F (up to the total number of each Product, Accessory or WIP set forth in Amended Exhibit F). All Products,
Accessories and WIP manufactured by Cohesion for Orthovita prior to and during the 4th calendar quarter of Calendar
Year 2005, as well as all WIP in Cohesion’s possession as of the Closing Date (up to the total amounts specified in Amended Exhibit F) shall be shipped and invoiced by Cohesion no later than the Closing Date. 
  
         (c)
        Cohesion shall use commercially reasonable efforts to supply the total number of units of each Product, Accessory and WIP set forth in Amended Exhibit F prior to the Closing Date. However, in
any event, Cohesion shall cease manufacturing at its manufacturing facility no later than the Closing Date, regardless of the total number of units of each Product, Accessory and WIP supplied to Orthovita prior to or as of the Closing Date. For the
sake of clarity, Cohesion shall have no obligation to supply any additional Products, Accessories or WIP to Orthovita after the Closing Date. Regardless of whether Orthovita (a) is capable of manufacturing Products and/or Accessories (or
processing or packaging WIP) itself, or is able to obtain Products and/or Accessories from a third party supplier, and/or (b) has obtained Regulatory Approval to manufacture Products and/or Accessories (or to process or package WIP) pursuant to
a Product Manufacturing Application (or other required application for Regulatory Approval) submitted by or on behalf of Orthovita, Orthovita shall be solely responsible, at Orthovita’s sole expense, for obtaining the CoStasis Ingredients and
for manufacturing (or having manufactured) and otherwise obtaining Products and Accessories after the Closing Date. Notwithstanding Section 2.3 of the Agreement, after the Closing Date Cohesion shall be under no obligation to maintain any of
its Product or Accessory Regulatory Approvals; provided that Cohesion shall maintain its approved U.S. Premarket Approval Application (“PMA”) in effect until Orthovita either obtains approval of its own PMA or determines that it will no
longer seek approval of its own PMA. 
  
         (d)         Notwithstanding anything to the contrary set forth in the Agreement, the Parties shall each bear their own costs and expenses in connection
with manufacturing technology transfer from Cohesion to Orthovita after the Effective Date 

  

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CONFIDENTIAL 
  
  
 
and neither Party shall be obligated to reimburse the other Party for any such costs or expenses. 
  
         (e)
        Notwithstanding anything in the Agreement, Orthovita shall be responsible for any storage and/or use of raw materials, CoStasis Ingredients, other components of Products or Accessories, WIP or its
components, or finished Products and Accessories (whether or not in kit form) at any time past the limits of the applicable stability data of Cohesion. Orthovita shall defend, indemnify and hold harmless Cohesion and its Affiliates and their
employees, officers, agents and directors against any Loss (including, without limitation, reasonable attorneys’ fees and expenses) that may be brought, instituted or arise against or be incurred by such person to the extent such Loss is based
on or arises out of, or relates to, claims, actions or suits (including a governmental investigation) relating to any raw materials, CoStasis Ingredients, other components of Products or Accessories, WIP or its components, or finished Products and
Accessories (whether or not in kit form) provided by Cohesion that are stored by Orthovita, or incorporated by Orthovita into a final finished product and sold to a customer or distributor, after expiration of the time period or nonconformance with
an applicable release specification corresponding to Cohesion’s stability study data for such raw material, CoStasis Ingredient, other component, WIP or its components, and/or finished Product or Accessory (as applicable). 
  
         (f)
        Orthovita further agrees that it shall not further process and/or package into final finished product any raw materials, CoStasis Ingredients, other components of Products or Accessories, WIP or its
components, or finished Products and Accessories (whether or not in kit form) until such time as Orthovita has obtained all Regulatory Approvals necessary in connection with such processing and/or packaging. 
  
 3.2     Purchase Orders. All open Purchase Orders
(to the extent unfilled as of the Amendment Effective Date) submitted by Orthovita are hereby canceled. Orthovita’s execution of this Amendment shall be deemed to constitute a firm and binding Purchase Order for all remaining, as yet
undelivered, numbers of units of Products, Accessories and WIP set forth in Exhibit G. Any raw materials supplied by Cohesion to Orthovita hereunder shall be provided ****. 
  

	4.	Miscellaneous. 

  
 4.1     Continuing Effect; Inconsistencies. This Amendment shall be effective for all purposes as of the Amendment Effective
Date. As of the Amendment Effective Date, the term “Agreement” (as used herein and in the Agreement) shall mean the Agreement as amended by this Amendment. Except as expressly modified herein, the Agreement shall remain in full force and
effect in accordance with its terms. To the extent that there are any inconsistencies between this Amendment and the unamended Agreement, the terms of this Amendment shall supersede those set forth in the unamended Agreement. 
  
 4.2    Governing Law. The construction, validity
and performance of this Amendment shall be governed in all respects by the laws of the State of California, U.S.A., excluding conflict of laws principles. 
  

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CONFIDENTIAL 
  
  
 4.3
    Counterparts. This Amendment may be executed in two or more counterparts, including by facsimile signature, each of which shall be deemed to be an original, but all of which together shall constitute one and the same
instrument. 
  
 IN WITNESS WHEREOF, the Parties hereto have caused this Amendment
to be signed by their respective duly authorized representatives as of the Amendment Effective Date. 
  

			
	ORTHOVITA, INC.	 	ANGIOTECH BIOMATERIALS CORP.
		
	 By: /s/ Antony Koblish
	 	 By: /s/ Thomas Bailey

		
	 Name: Antony Koblish
	 	 Name: Thomas Bailey

		
	 Title: President & CEO
	 	 Title: VP Business Development

		
	 Date: 27-Oct-05
	 	 Date: 10/24/05

  

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CONFIDENTIAL 
  
  
 AMENDED EXHIBIT F 
  
 Price and Numbers of Products to be Supplied by Cohesion between the
Effective Date of the Agreement and the Closing Date 
  

											
	 	 	 	 	 	 
	Item	 	Unit Size Information	 	Price A    	 	Number of    
Units at Price A    	 	Price B    	 	Number
of    
Units at Price B    
	 	 	 	 	 	 
	 CoStasis Product
	 	 4.5 ml unit dose package
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product
	 	 2.0 ml unit dose package
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CellPaker Product
	 	 Box of 10 CellPaker Product units
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (MEA)
	 	 Box of 5 MEA units
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (LEA)
	 	 Box of 10 LEA units
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product WIP    
	 	 4.5 ml unit dose size:
 Vitagel syringes
 Non-sterile transfer syringes    
 Non-sterile delivery
sets
  
	 	****    	 	****    	 	****    	 	****    

  
 *Excludes MEA and LEA units listed on Exhibit B of the Agreement 

 
CONFIDENTIAL 
  
  
 EXHIBIT G 
  
 Price and Numbers of Products still to be Supplied by Cohesion between the

 Amendment Effective Date and the Closing Date 
  

											
	Item	 	Unit Size Information	 	Price A    	 	Number of Units    
to be
supplied    
after Amendment    
Effective date at    
Price A    	 	Price B    	 	Number of Units    
to be
supplied    
after Amendment    
Effective date at    
Price B    
	 	 	 	 	 	 
	 CoStasis Product
	 	 4.5 ml unit dose package
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product
	 	 2.0 ml unit dose package
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CellPaker Product
	 	 Box of 10 CellPaker Product units    
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (MEA)
	 	 Box of 5 MEA units
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (LEA)
	 	 Box of 10 LEA units
	 	****    	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product WIP    
	 	 4.5 ml unit dose size:
 Vitagel syringes
 Non-sterile transfer syringes    
 Non-sterile delivery
sets
  
	 	****    	 	****    	 	****    	 	****    

 
CONFIDENTIAL 
  
  
 EXHIBIT H 
  
 Numbers of Products still Subject to the Royalty 
  

											
	 	 	 	 	 	 	Number of Units for    
which a Royalty was    
paid at the
rates set    
forth in Exhibit E    
prior to the    
Amendment    
Effective Date    	 	Number of Units still    
Subject to a Royalty    
at the rates
set forth    
in Exhibit E after    
Amendment    
Effective Date    	 	Number of Units still    
Subject to a
Royalty    
at a rate of ****    
after Amendment    
Effective Date    
	Item	 	Unit Size
Information	 	Price A  	 	Column A	 	Column B	 	Column C
	 	 	 	 	 	 
	 CoStasis Product  
	 	 4.5 ml unit dose package
	 	****	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product
	 	 2.0 ml unit dose package
	 	****	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CellPaker Product
	 	 Box of 10 CellPaker Product units    
	 	****	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (MEA)
	 	 Box of 5 MEA units
	 	****	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 Accessory (LEA)
	 	 Box of 10 LEA units
	 	****	 	****    	 	****    	 	****    
	 	 	 	 	 	 
	 CoStasis Product WIP
	 	 4.5 ml unit dose size:
 Vitagel syringes
 Non-sterile transfer syringes
 Non-sterile delivery sets
  
	 	****	 	****    	 	****    	 	****

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00093-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00093-of-00352.parquet"}]]