Document:

First Amendment to Rights Agreement

 Exhibit 4.1 
 FIRST AMENDMENT TO RIGHTS AGREEMENT 
 This
FIRST AMENDMENT TO RIGHTS AGREEMENT (this “Amendment”), dated as of April 5, 2010, is made and entered into by and between
ACCELRYS, INC. (formerly Pharmacopeia, Inc.), a Delaware corporation (the “Company”), and AMERICAN STOCK TRANSFER & TRUST
CO., as rights agent (the “Rights Agent”). Capitalized terms not otherwise defined in this Amendment shall have the meaning ascribed to such terms in the Rights Agreement (as defined below).
 WHEREAS, the Company and the Rights Agent previously entered into that certain Rights Agreement, dated
as of September 6, 2002 (the “Rights Agreement”); 
 WHEREAS, the
Company proposes to enter into an Agreement and Plan of Merger and Reorganization (as it may be amended from time to time, the “Merger Agreement”) with Alto Merger Sub, Inc., a Delaware corporation and a wholly-owned subsidiary of
the Company (“Merger Sub”), and Symyx Technologies, Inc., a Delaware corporation (“Symyx”), pursuant to which Merger Sub will merge with and into Symyx, the separate corporate existence of Merger Sub will cease and
Symyx will survive as a wholly-owned subsidiary of the Company (the “Merger”); 
 WHEREAS, the Board of Directors of the Company has determined that, in connection with the execution of the Merger Agreement, it is necessary and desirable to amend the Rights Agreement to exempt, among
other things, the Merger Agreement, the execution thereof and the transactions contemplated thereby, including, without limitation, the Merger, from the application of the Rights Agreement, in each case as set forth in this Amendment; and

 WHEREAS, (i) Section 27 of the Rights Agreement provides that, prior to the
occurrence of a Distribution Date or Triggering Event, the Company may, without the approval of any holders of certificates representing shares of Common Stock and associated Rights, supplement or amend any provision of the Rights Agreement;
(ii) pursuant to the terms of the Rights Agreement and in accordance with Section 27 thereof, the Company has directed that the Rights Agreement should be amended and supplemented as set forth in this Amendment prior to the execution of
the Merger Agreement; and (iii) pursuant to Section 27 of the Rights Agreement, an appropriate officer of the Company is hereby delivering a certificate to the Rights Agent stating that this Amendment complies with the terms of
Section 27 of the Rights Agreement and does not change or increase the Rights Agent’s duties, liabilities, rights or obligations under Rights Agreement. 

 NOW, THEREFORE, in consideration of the
premises and the mutual agreements herein set forth, the parties hereby agree as follows: 
 1. Amendments to Rights
Agreement. 
  

	 	(a)	The definition of “Acquiring Person” in Section 1(a) of the Rights Agreement is amended by inserting the following as a new paragraph at the end of such
definition: 

 “Notwithstanding anything in this Section 1(a) to the contrary, neither Symyx
Technologies, Inc., a Delaware corporation (“Symyx”), nor any of its stockholders, nor any of their respective Affiliates or Associates, either individually or in any combination, shall be deemed to be or become an “Acquiring
Person” by virtue of, or as a result of (i) the approval, execution, delivery or performance of the Agreement and Plan of Merger and Reorganization, dated April 5, 2010, by and among the Company, Alto Merger Sub, Inc., a Delaware
corporation and a wholly-owned subsidiary of the Company (“Merger Sub”), and Symyx (the “Merger Agreement”), (ii) the execution and delivery of the Company Stockholder Voting Agreements (as defined in the Merger Agreement)
by and between the Company and certain stockholders of Symyx, or (iii) the performance or consummation of any of the other Contemplated Transactions (as defined in the Merger Agreement), including without limitation, the Merger (the foregoing
actions being referred to as the “Permitted Events”).” 
  

	 	(b)	The definition of “Stock Acquisition Date” in Section 1(hh) of the Rights Agreement is amended to add the following sentence at the end thereof:

 “Notwithstanding anything in this Agreement to the contrary, a Stock Acquisition Date shall not be deemed
to have occurred by virtue of, or as a result of, any Permitted Event or the public announcement thereof.” 
  

	 	(c)	Section 3(a) of the Rights Agreement is amended to add the following sentence at the end thereof: 

 “Notwithstanding anything in this Agreement to the contrary, a Distribution Date shall not be deemed to have occurred, and no separate
Rights Certificate will be issued or issuable, by virtue of, or as the result of, any Permitted Event.” 
 2.
Officer’s Certificate. By executing this Amendment below, the undersigned duly appointed officer of the Company certifies that this Amendment has been executed and delivered in compliance with the terms of Section 27 of the Rights
Agreement and does not change or increase the Rights Agent’s duties, liabilities, rights or obligations under the Rights Agreement. 
 3. Interpretation. The term “Agreement” as used in the Rights Agreement shall be deemed to refer to the Rights Agreement as amended hereby. 
 4. Severability. If any term, provision, covenant or restriction of this Amendment is held by a court of competent jurisdiction or
other authority to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Amendment, and of the Rights Agreement, shall remain in full force and effect and shall in no way be affected, impaired
or invalidated. 
 5. Waiver of Notice. The Rights Agent and the Company hereby waive any notice requirement
under the Rights Agreement pertaining to the matters covered by this Amendment. 

 6. Effectiveness. This Amendment shall be deemed effective as of the date first
written above. Except as expressly amended herein, all other terms and conditions of the Rights Agreement shall remain in full force and effect. Without limiting the foregoing, the Rights Agent shall not be subject to, nor required to
interpret or comply with, or determine if any Person has complied with, the Merger Agreement even though reference thereto may be made in this Amendment and the Rights Agreement. 
 7. Termination. Notwithstanding anything to the contrary set forth herein, this Amendment shall terminate and be of no further force
or effect in the event of the termination of the Merger Agreement for any reason. 
 8. Governing Law. This Amendment
shall be deemed a contract made under the laws of the State of Delaware, and for all purposes of this Amendment shall be governed by and construed in accordance with the laws of such State applicable to contracts made and to be performed entirely
within such State. 
 9. Counterparts. This Amendment may be executed in any number of counterparts (including by
facsimile), each of which shall be an original and all of which shall constitute one and the same document. 
 [REMAINDER OF PAGE
INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, the
parties have caused this Amendment to be duly executed as of the day and year first written above. 
  

			
	ACCELRYS, INC.
		
	By:	 	 /s/ David R. Mersten

	Name:	 	David R. Mersten
	Title:	 	 Senior Vice President,
 General Counsel and Secretary

	
	 AMERICAN STOCK TRANSFER & TRUST CO.,
 as Rights Agent

		
	By:	 	 /s/ Paula Caroppoli

	Name:	 	Paula Caroppoli
	Title:	 	Vice PresidentForm of Voting Agreement

 Exhibit 10.1 
 VOTING AGREEMENT 
 THIS
VOTING AGREEMENT (“Voting Agreement”) is entered into as of April 5, 2010, by and between ACCELRYS, INC., a Delaware corporation
(“Parent”), and              (“Stockholder”). 
 RECITALS 
 A. Stockholder is a holder of record and
the “beneficial owner” (within the meaning of Rule 13d-3 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”)) of certain shares of common stock of Symyx Technologies, Inc., a Delaware corporation
(the “Company”). 
 B. Parent, Alto Merger Sub, Inc., a Delaware corporation (“Merger
Sub”), and the Company are entering into an Agreement and Plan of Merger and Reorganization of even date herewith (the “Merger Agreement”), which provides (subject to the conditions set forth therein) for the merger of
Merger Sub into the Company (the “Merger”). Capitalized terms used but not otherwise defined in this Voting Agreement have the meanings assigned to such terms in the Merger Agreement. 
 C. In the Merger, each outstanding share of common stock of the Company is to be converted into the right to receive 0.7802 shares of
Parent Common Stock. 
 D. Stockholder is entering into this Voting Agreement in order to induce Parent to enter into the
Merger Agreement and cause the Merger to be consummated. 
 AGREEMENT 
 The parties to this Voting Agreement, intending to be legally bound, agree as follows: 
 SECTION 1. CERTAIN DEFINITIONS 
 For purposes of this Voting Agreement: 
 (a) “Expiration
Date” shall mean the earlier of: (i) the date on which the Merger Agreement is terminated pursuant to Section 8 thereof; (ii) the date upon which the Merger becomes effective; or (iii) such date and time as any amendment
or change to the Merger Agreement is effected without the Stockholder’s consent that (A) decreases the Exchange Ratio or (B) materially and adversely affects the Stockholder. 
 (b) Stockholder shall be deemed to “Own” or to have acquired “Ownership” of a security if
Stockholder: (i) is the record owner of such security; or (ii) is the “beneficial owner” (within the meaning of Rule 13d-3 under the Exchange Act) of such security. 
 (c) “Subject Securities” shall mean: (i) all securities of the Company (including all shares of Company Common
Stock and all options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock) Owned by Stockholder as of the date of this Voting Agreement; and (ii) all additional securities of the Company (including all
additional shares of Company Common Stock and all additional options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock) of which Stockholder acquires Ownership during the Voting Period (whether such
acquisition is a result of purchases or other transfers of Company Common Stock to Stockholder or by virtue of a stock dividend, stock split, recapitalization, reclassification, subdivision, combination or exchange of shares). 

 (d) A Person shall be deemed to have effected a “Transfer” of a
security if such Person directly or indirectly: (i) sells, pledges, encumbers, grants an option with respect to, transfers or disposes of such security or any interest in such security to any Person other than Parent; (ii) enters into an
agreement or commitment contemplating the possible sale of, pledge of, encumbrance of, grant of an option with respect to, transfer of or disposition of such security or any interest therein to any Person other than Parent; or (iii) reduces
such Person’s beneficial ownership of, interest in or risk relating to such security. 
 (e) “Voting
Period” shall mean the period commencing on the date of this Voting Agreement and ending on the Expiration Date. 
 SECTION 2.
TRANSFER OF SUBJECT SECURITIES AND VOTING RIGHTS 
 2.1 Restriction on Transfer of Subject Securities. Subject to Section 2.3, during the Voting Period, Stockholder shall not, directly or indirectly, cause or permit any Transfer of any
of the Subject Securities to be effected; provided, however, that nothing contained in this Voting Agreement will be deemed to restrict the ability of Stockholder to exercise any Company Equity Awards held by Stockholder prior to the
Expiration Date. 
 2.2 Restriction on Transfer of Voting Rights. During the Voting Period, Stockholder shall ensure
that: (a) none of the Subject Securities is deposited into a voting trust; and (b) no proxy is granted inconsistent with this Voting Agreement, and no voting agreement or similar agreement is entered into, with respect to any of the
Subject Securities. 
 2.3 Permitted Transfers. Section 2.1 shall not prohibit a Transfer of Subject Securities by
Stockholder: (a) if Stockholder is an individual: (i) to any member of Stockholder’s immediate family; or to a trust for the benefit of Stockholder or any member of Stockholder’s immediate family; or (ii) upon the death of
Stockholder; or (b) if Stockholder is a partnership or limited liability company, to one or more partners or members of Stockholder or to an affiliated corporation under common control with Stockholder; provided, however, that a Transfer
referred to in this Section 2.3 shall be permitted only if, as a precondition to such Transfer, the transferee agrees in a writing, reasonably satisfactory in form and substance to Parent, to be bound by all of the terms of this Voting
Agreement. 
 SECTION 3. VOTING OF SHARES 
 3.1 Voting Covenant. Stockholder hereby agrees that, prior to the Expiration Date, at any meeting of the stockholders of the
Company, however called, or at any adjournment or postponement thereof and on every action or approval by written consent of the stockholders of the Company, unless otherwise directed in writing by Parent, Stockholder shall cause any issued and
outstanding shares of Company Common Stock Owned by Stockholder as of the record date with respect to such meeting to be voted: 
 (a) in favor of the adoption of the Merger Agreement; 
 (b) against any Company Acquisition Proposal;
and 
 (c) against any other action, agreement, proposal or transaction involving any of the Symyx Corporations which
other action, agreement, proposal or transaction would compete with, interfere with, impede, frustrate, prevent, burden or nullify the Merger or the Merger Agreement. 
  

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 Prior to the Expiration Date, Stockholder shall not enter into any agreement or understanding with any
Person to vote or give instructions in any manner inconsistent with clause “(a),” clause “(b)” or clause “(c)” of the preceding sentence. 
 3.2 PROXY 
 (a) Contemporaneously with
the execution of this Voting Agreement: (i) Stockholder shall deliver to Parent a proxy in the form attached to this Voting Agreement as Exhibit A, which shall be irrevocable to the fullest extent permitted by law (at all times during
the Voting Period) with respect to the shares referred to therein (the “Proxy”); and (ii) if applicable, Stockholder shall cause to be delivered to Parent an additional proxy (in the form attached hereto as Exhibit A)
executed on behalf of the record owner of any outstanding shares of Company Common Stock that are owned beneficially (within the meaning of Rule 13d-3 under the Exchange Act), but not of record by Stockholder. 
 (b) Stockholder shall not enter into any tender, voting or other agreement, or grant a proxy or power of attorney, with respect to
the Subject Securities that is inconsistent with this Voting Agreement or otherwise take any other action with respect to the Subject Securities that would in any way restrict, limit or interfere with the performance of Stockholder’s
obligations hereunder or the transactions contemplated hereby. 
 SECTION 4. ADDITIONAL COVENANTS
OF STOCKHOLDER 
 4.1 No Solicitation. Stockholder agrees that, during the Voting
Period, Stockholder shall not (without limiting any of the other restrictions in this Voting Agreement), directly or indirectly, take or authorize to be taken any action that the Company is prohibited from taking or authorizing to be taken pursuant
to Section 4.4 of the Merger Agreement 
 4.2 Notice of Certain Events. Stockholder agrees to promptly notify Parent
of any development occurring after the date hereof that causes any breach of any of the representations and warranties of Stockholder set forth in Section 5 herein. 
 SECTION 5. REPRESENTATIONS AND WARRANTIES OF STOCKHOLDER 
 Stockholder hereby represents and warrants to Parent as follows: 
 5.1 Authorization, etc. Stockholder has the power, authority and capacity to execute and deliver this Voting Agreement and the
Proxy and to perform Stockholder’s obligations hereunder and thereunder. This Voting Agreement and the Proxy have been duly executed and delivered by Stockholder and, assuming the due authorization, execution and delivery of this Voting
Agreement by Parent, constitute legal, valid and binding obligations of Stockholder, enforceable against Stockholder in accordance with their terms, subject to: (a) laws of general application relating to bankruptcy, insolvency and the relief
of debtors; and (b) rules of law governing specific performance, injunctive relief and other equitable remedies. 
 5.2
No Conflicts or Consents. 
 (a) The execution and delivery of this Voting Agreement and the Proxy by Stockholder do
not, and the performance of this Voting Agreement and the Proxy by Stockholder will not: (i) conflict with or violate any Legal Requirement or Order applicable to Stockholder or by which Stockholder or any of Stockholder’s properties is or
may be bound or affected; or (ii) result in or

  

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constitute (with or without notice or lapse of time) any breach of or default under, or give to any other Person (with or without notice or lapse of time) any right of termination, amendment,
acceleration or cancellation of, or result (with or without notice or lapse of time) in the creation of any Encumbrance on any of the Subject Securities. 
 (b) The execution and delivery of this Voting Agreement and the Proxy by Stockholder do not, and the performance of this Voting Agreement and the Proxy by Stockholder will not, require any Consent
of any Person. 
 5.3 Title to Securities. As of the date of this Voting Agreement: (a) Stockholder holds of record
(free and clear of any Encumbrances) the number of outstanding shares of Company Common Stock set forth under the heading “Shares Held of Record” on the signature page hereof; (b) Stockholder holds (free and clear of any Encumbrances)
the options, restricted stock units, warrants and other rights to acquire shares of Company Common Stock set forth under the heading “Options and Other Rights” on the signature page hereof; (c) Stockholder Owns the additional
securities of the Company set forth under the heading “Additional Securities Beneficially Owned” on the signature page hereof; and (d) Stockholder does not directly or indirectly Own any shares of capital stock or other securities of
the Company, or any option, restricted stock unit, warrant or other right to acquire (by purchase, conversion or otherwise) any shares of capital stock or other securities of the Company, other than the shares and options, restricted stock units,
warrants and other rights set forth on the signature page hereof. 
 5.4 Accuracy of Representations. The representations
and warranties contained in this Voting Agreement are accurate in all respects as of the date of this Voting Agreement, and will be accurate in all respects at all times prior to the Expiration Date as if made as of any such time or date.

 SECTION 6. MISCELLANEOUS 
 6.1 Stockholder Information. Stockholder hereby agrees to permit Parent, the Company and Merger Sub to publish and disclose in the Form S-4 Registration Statement, the Joint Proxy
Statement/Prospectus and any other public disclosure that Parent and the Company mutually determine to be necessary or desirable in connection with the Merger and any other transactions contemplated by the Merger Agreement Stockholder’s
identity and ownership of shares of Company Common Stock and the nature of Stockholder’s commitments, arrangements and understandings under this Voting Agreement. 
 6.2 Further Assurances. From time to time and without additional consideration, Stockholder shall execute and deliver, or cause to be executed and delivered, such additional transfers, assignments,
endorsements, proxies, consents and other instruments, and shall take such further actions, as Parent may reasonably request for the purpose of carrying out and furthering the intent of this Voting Agreement. 
 6.3 Expenses. All costs and expenses incurred in connection with the transactions contemplated by this Voting Agreement shall be paid
by the party incurring such costs and expenses. 
 6.4 Notices. Any notice or other communication under this Voting
Agreement shall be in writing and shall be deemed to have been duly given or made as follows: (a) if sent by registered or certified mail in the United States return receipt requested, upon receipt; (b) if sent by nationally recognized
overnight air courier (such as Federal Express), one business day after mailing; (c) if sent by facsimile transmission before 5:00 p.m., when transmitted and receipt is confirmed; (d) if sent by facsimile transmission after 5:00 p.m. and
receipt is confirmed, on the following business day; and (e) if otherwise actually personally delivered, when delivered, provided that such notices, requests, demands and other communications are delivered to the address set forth below, or to
such other address as any party shall provide by like notice to the other parties to this Voting Agreement: 
 if to
Stockholder: 
 at the address set forth on the signature page hereof; and 
  

 4 

 if to Parent: 
 Accelrys, Inc. 
 10188 Telesis Court, Suite 100 
 San Diego, CA 92121 
 Attention: David R. Mersten, Esq. 
 Facsimile: (858) 799-5107 
 with a copy to: 
 Paul, Hastings, Janofsky & Walker LLP 
 4747 Executive Drive, Ste 1200 
 San Diego, CA 92121 
 Attention: Carl R. Sanchez 
 Facsimile: (858) 458-3130 
 6.5 Severability. Any term or provision of
this Voting Agreement that is invalid or unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this Voting Agreement or the validity or enforceability of the
offending term or provision in any other situation or in any other jurisdiction. Upon such determination that any term or provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this
Voting Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the fullest extent possible. 
 6.6 Entire Agreement. This Voting Agreement, the Proxy, the Merger Agreement and any other documents delivered by the parties in
connection herewith constitute the entire agreement between the parties with respect to the subject matter hereof and thereof and supersede all prior agreements and understandings between the parties with respect thereto. 
 6.7 Amendments. This Voting Agreement may not be amended, modified, altered or supplemented other than by means of a written
instrument duly executed and delivered on behalf of Parent and Stockholder. 
 6.8 Assignment; Binding Effect; No Third Party
Rights. Except as provided herein, neither this Voting Agreement nor any of the interests or obligations hereunder may be assigned or delegated by Stockholder, and any attempted or purported assignment or delegation of any of such interests or
obligations shall be void. Subject to the preceding sentence, this Voting Agreement shall be binding upon Stockholder and Stockholder’s heirs, estate, executors and personal representatives and Stockholder’s successors and assigns, and
shall inure to the benefit of Parent and its successors and assigns. Without limiting any of the restrictions set forth in Section 2, Section 3 or elsewhere in this Voting Agreement, this Voting Agreement shall be binding upon any Person
to whom any Subject Securities are transferred. Nothing in this Voting Agreement is intended to confer on any Person (other than Parent and its successors and assigns) any rights or remedies of any nature. 
  

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 6.9 Specific Performance. The parties agree that irreparable damage would
occur in the event that any of the provisions of this Voting Agreement or the Proxy were not performed in accordance with its specific terms or were otherwise breached. Stockholder agrees that, in the event of any breach or threatened breach by
Stockholder of any covenant or obligation contained in this Voting Agreement or in the Proxy, Parent shall be entitled (in addition to any other remedy that may be available to it, including monetary damages) to obtain: (a) a decree or order of
specific performance to enforce the observance and performance of such covenant or obligation; and (b) an injunction restraining such breach or threatened breach. Stockholder further agrees that neither Parent nor any other Person shall be
required to obtain, furnish or post any bond or similar instrument in connection with or as a condition to obtaining any remedy referred to in this Section 6.9, and Stockholder irrevocably waives any right he or it may have to require the
obtaining, furnishing or posting of any such bond or similar instrument. 
 6.10 Attorneys’ Fees. If any Legal
Proceeding relating to this Voting Agreement or the enforcement of any provision of this Voting Agreement is brought against Stockholder, the prevailing party shall be entitled to recover reasonable attorneys’ fees, costs and disbursements (in
addition to any other relief to which the prevailing party may be entitled). 
 6.11 Non-Exclusivity. The rights and
remedies of Parent under this Voting Agreement are not exclusive of or limited by any other rights or remedies which it may have, whether at law, in equity, by contract or otherwise, all of which shall be cumulative (and not alternative).

 6.12 Governing Law; Jurisdiction; Waiver of Jury Trial. This Voting Agreement and the Proxy shall be governed by, and
construed in accordance with, the laws of the State of Delaware, regardless of the laws that might otherwise govern under applicable principles of conflicts of laws thereof. In any action between any of the parties arising out of or relating to this
Voting Agreement, the Proxy or any of the transactions contemplated by this Voting Agreement or the Proxy, each of the parties: (a) irrevocably and unconditionally consents and submits to the exclusive jurisdiction and venue of the Chancery
Court of the State of Delaware; (b) irrevocably waives the right to trial by jury; and (c) irrevocably consents to service of process by first class certified mail, return receipt requested, postage prepaid, to the address at which
Stockholder or Parent, as the case may be, is to receive notice in accordance with Section 6.4. 
 6.13 Counterparts;
Exchanges by Facsimile or Electronic Delivery. This Voting Agreement may be executed in separate counterparts, each of which when so executed and delivered shall be an original, but all such counterparts shall together constitute one and
the same instrument. The exchange of a fully executed Voting Agreement (in counterparts or otherwise) by facsimile or electronic delivery shall be sufficient to bind the parties to the terms and conditions of this Voting Agreement. 
 6.14 Captions. The captions contained in this Voting Agreement are for convenience of reference only, shall not be deemed to be a
part of this Voting Agreement and shall not be referred to in connection with the construction or interpretation of this Voting Agreement. 
 6.15 Waiver. Subject to the remainder of this Section 6.15, at any time prior to the Expiration Date, any party hereto may: (a) extend the time for the performance of any of the
obligations or other acts of the other parties to this Voting Agreement; (b) waive any inaccuracy in or breach of any representation, warranty, covenant or obligation of the other party in this Voting Agreement or in any document delivered
pursuant to this Voting Agreement; and (c) waive compliance with any covenant, obligation or condition for the benefit of such party contained in this Voting Agreement. No failure on the part of Parent to exercise any power, right, privilege or
remedy under this Voting Agreement, and no delay on the part of Parent in exercising any power, right, privilege or remedy under this Voting Agreement, shall

  

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operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power, right, privilege or remedy shall preclude any other or further exercise thereof
or of any other power, right, privilege or remedy. Parent shall not be deemed to have waived any claim available to Parent arising out of this Voting Agreement, or any power, right, privilege or remedy of Parent under this Voting Agreement, unless
the waiver of such claim, power, right, privilege or remedy is expressly set forth in a written instrument duly executed and delivered on behalf of Parent; and any such waiver shall not be applicable or have any effect except in the specific
instance in which it is given. 
 6.16 Independence of Obligations. The covenants and obligations of Stockholder
set forth in this Voting Agreement shall be construed as independent of any other Contract between Stockholder, on the one hand, and the Company or Parent, on the other. The existence of any claim or cause of action by Stockholder against the
Company or Parent shall not constitute a defense to the enforcement of any of such covenants or obligations against Stockholder. Nothing in this Voting Agreement shall limit any of the rights or remedies of Parent under the Merger Agreement, or any
of the rights or remedies of Parent or any of the obligations of Stockholder under any agreement between Stockholder and Parent or any certificate or instrument executed by Stockholder in favor of Parent; and nothing in the Merger Agreement or in
any other such agreement, certificate or instrument, shall limit any of the rights or remedies of Parent or any of the obligations of Stockholder under this Voting Agreement. 
 6.17 Other Capacities. Notwithstanding any provision of this Voting Agreement to the contrary, nothing in this Voting
Agreement shall limit or restrict Stockholder from acting in good faith in Stockholder’s capacity as a director or officer of the Company (it being understood that this Voting Agreement shall apply to Stockholder solely in Stockholder’s
capacity as a stockholder of the Company). 
 6.18 Construction. 
 (a) For purposes of this Voting Agreement, whenever the context requires: the singular number shall include the plural, and vice
versa; the masculine gender shall include the feminine and neuter genders; the feminine gender shall include the masculine and neuter genders; and the neuter gender shall include masculine and feminine genders. 
 (b) The parties agree that any rule of construction to the effect that ambiguities are to be resolved against the drafting party
shall not be applied in the construction or interpretation of this Voting Agreement. 
 (c) As used in this Voting
Agreement, the words “include” and “including,” and variations thereof, shall not be deemed to be terms of limitation, but rather shall be deemed to be followed by the words “without limitation.” 
 (d) Except as otherwise indicated, all references in this Voting Agreement to “Sections” and “Exhibits” are
intended to refer to Sections of this Voting Agreement and Exhibits to this Voting Agreement. 
 [Remainder of page
intentionally left blank.] 
  

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 IN WITNESS WHEREOF, Parent and
Stockholder have caused this Voting Agreement to be executed as of the date first written above. 
  

			
	ACCELRYS, INC.
	
	  

	By	 	
	  

	Title	 	
	
	STOCKHOLDER
	
	  

	Signature	 	
	  

	Printed Name
		
	Address:	 	  

		 	  

		 	  

		
	Facsimile:	 	  

  

					
	 Shares Held of Record
	 	 Options and Other Rights
	 	 Additional Securities
 Beneficially Owned

 EXHIBIT A 
 FORM OF IRREVOCABLE PROXY 
 Proxy 

 IRREVOCABLE PROXY 
 The undersigned stockholder (the “Stockholder”) of Symyx Technologies, Inc. a Delaware corporation (the
“Company”), hereby irrevocably (to the fullest extent permitted by law) appoints and constitutes Accelrys, Inc., a Delaware corporation (“Parent”), and Max Carnecchia and Michael A. Piraino, solely in their
capacities as executive officers of Parent, and each of them, the attorneys and proxies of the Stockholder, with full power of substitution and resubstitution, to the full extent of the Stockholder’s rights with respect to the outstanding
shares of capital stock of the Company owned of record by the Stockholder as of the date of this proxy, which shares are specified on the final page of this proxy. (The shares of the capital stock of the Company referred to in the immediately
preceding sentence are referred to as the “Shares.”) Upon the execution of this proxy, all prior proxies given by the Stockholder with respect to any of the Shares are hereby revoked, and the Stockholder agrees that no subsequent
proxies inconsistent with this Proxy will be given with respect to any of the Shares. 
 This proxy is irrevocable, is coupled
with an interest and is granted in connection with, and as security for, the Voting Agreement, dated as of the date hereof, between Parent and the Stockholder (the “Voting Agreement”), and is granted in consideration of Parent
entering into the Agreement and Plan of Merger and Reorganization, dated as of the date hereof, among Parent, Alto Merger Sub, Inc., a wholly-owned subsidiary of Parent, and the Company (the “Merger Agreement”). This proxy will
terminate on the Expiration Date (as defined in the Voting Agreement). 
 Prior to the Expiration Date, the attorneys and
proxies named above will be empowered, and may exercise this proxy, to vote any Shares owned by the undersigned, at any meeting of the stockholders of the Company, however called, or at any adjournment or postponement thereof and on every action or
approval by written consent of the stockholders of the Company: 
 (a) in favor of the adoption of the Merger Agreement;

 (b) against any Company Acquisition Proposal (as such terms are defined in the Merger Agreement); and 
 (c) against any other action, agreement, proposal or transaction involving any of the Symyx Corporations which other action, agreement,
proposal or transaction would compete with, interfere with, impede, frustrate, prevent, burden or nullify the Merger or the Merger Agreement. 
 The Stockholder may vote the Shares on all other matters not referred to in this proxy, and the attorneys and proxies named above may not exercise this proxy with respect to such other matters.

 This proxy shall be binding upon the heirs, estate, executors, personal representatives, successors and assigns of the
Stockholder (including any transferee of any of the Shares). 
 Any term or provision of this proxy that is invalid or
unenforceable in any situation in any jurisdiction shall not affect the validity or enforceability of the remaining terms and provisions of this proxy or the validity or enforceability of the offending term or provision in any other situation or in
any other jurisdiction. Upon such determination that any term or provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this proxy so as to effect the original intent of the parties
as closely as possible in an acceptable manner to the end that the transactions contemplated hereby are fulfilled to the fullest extent possible. 
 [Signature page follows] 
 Proxy 

			
	Dated: April 5, 2010	 	STOCKHOLDER
		
		 	  

		 	Signature
		 	  

		 	Printed Name
		
		 	Number of shares of common stock of the Company owned of record as of the date of this proxy:
		 	  

 Proxy

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