Document:

Exhibit 10.18

    
      

    

     

    Animal
      Study Agreement

    

    This
      CLINICAL
      STUDY AGREEMENT
      (the
      "Agreement") between Universidade Federal de Sao Paulo, hereinafter referred
      to
      as "University," and Neurologix, Inc., hereinafter referred to as the "Sponsor,"
      is entered into as of October 20, 2004 ("Effective Date").

    

    WHEREAS,
      the
      program contemplated by this Agreement, consisting of an animal study in
      accordance with the Protocol titled "Animal Research in Primates affected by
      Epilepsy Using Direct Delivery of Neuropeptide Y and Galanin in the Brain"
      ("Protocol") (a copy of the Protocol is attached hereto as Attachment A), is
      of
      mutual interest and benefit to the University and to the Sponsor, and will
      further the instructional and research objectives of the University in a manner
      consistent with its status as a non-profit, tax-exempt, educational
      institution,

    

    NOW,
      THEREFORE,
      the
      parties hereto agree as follows:

    

    
      	
              1.

            	
              THE
                SCOPE OF WORK.
                The University agrees to use all reasonable efforts to perform the
                animal
                study in accordance with the Protocol (the "Study"). The University
                represents and warrants that the animals used in the study shall
                be
                normal, healthy animals that have never been used in any previous
                study or
                experiment, and have never been intentionally infected with any
                disease.

            

    

    

    
      	
              2.

            	
              PRINCIPAL
                INVESTIGATOR.
                The Study will be supervised by Prof. Luiz Eugenio A. M. Mello (the
                "Principal Investigator"). If, for any reason, he is unable to continue
                to
                serve as Principal Investigator, and a successor acceptable to both
                the
                University and the Sponsor is not available, this Agreement shall
                be
                terminated as provided in Article
                5.

            

    

    

    
      	
              3.

            	
              PERIOD
                OF PERFORMANCE. The
                Study shall be conducted on sixteen (16) marmosets in accordance
                with the
                Protocol.

            

    

    

    
      	
              4.

            	
              PAYMENT/REIMBURSEMENT
                OF COSTS.
                The total cost of the Study shall by US $62,200.00. Payments shall
                be made
                to the University by the Sponsor in advance in U.S. dollars, net
                of taxes
                or impost of any kind, on the terms and schedule set forth in Attachment
                B.

            

    

    

    
      	
              5.

            	
              TERMINATION.
                Performance under this Agreement may be terminated by the Sponsor
                upon
                thirty (30) days prior written notice. Performance may be terminated
                by
                the University if circumstances beyond its reasonable control preclude
                continuation of the Study. Upon termination, the University will
                be
                reimbursed as specified in Article 4 for all costs incurred in the
                performance of the Study prior to the termination, and any non-cancelable
                commitments incurred in the performance of the Study, such reimbursement
                not to exceed the total estimated project costs specified in Article
                4.

            

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
              6.

            	
              PUBLICATIONS
                AND COPYRIGHTS.
                The University will be free to publish the results of the Study after
                providing the Sponsor with a thirty (30) day period in which to review
                each publication to identify patentable subject matter, and to identify
                any inadvertent disclosure of the Sponsor's proprietary information.
                University will not disclose Sponsor's confidential information without
                permission. Sponsor shall not have editorial rights over manuscripts
                or
                presentations, but may comment on implications of publication timing
                for
                multiple site studies or request deletion of Sponsor's confidential
                or
                proprietary information. If necessary to permit the preparation and
                filing
                of U.S. or other country patent applications, the Principal Investigator
                shall agree to an additional review period not to exceed sixty (60)
                days.
                Any further extension will require subsequent agreement between the
                Sponsor and the University.

            

    

    

    The
      Sponsor will be given full credit and acknowledgment for the support provided
      to
      the University in any publication resulting from this research. Title to, and
      the right to determine the disposition of, any copyrights, or copyrightable
      material, first produced or composed in the performance of this research, shall
      remain with the University. The University shall grant to the Sponsor an
      irrevocable, royalty-free, perpetual, unrestricted, non-exclusive right to
      reproduce, translate, prepare derivative works, distribute, and use all such
      research data (including any informational database into which such data is
      entered) and copyrighted material for its own purposes, including, but not
      limited to, submission to the United States Food and Drug
      Administration.

    

    
      	
              7.

            	
              A.
                  
                INVENTIONS
                AND PATENTS.
                Should any invention be created during the course of the Study, the
                University will disclose each such invention to the Sponsor within
                two
                months after the inventor discloses it in writing to the University
                personnel responsible for patent matters. The disclosure to the Sponsor
                shall be in the form of a written report and shall identify the funding
                Agreement under which the invention was made and the
                inventor(s).

            

    

    

    If,
      with
      respect to a University Invention (as defined below) the Sponsor requests a
      license in a reported invention within 45 days of receipt of the invention
      report, the University:

    

    
      	 	
              (a)

            	
              Will
                use reasonable efforts to solicit US Patent
                protection;

            

    

    

    
      	 	
              (b)

            	
              Will
                negotiate in good faith a license with reasonable initial payments,
                royalties, and minimum royalties;
                and

            

    

    

    If
      patent
      rights in other countries are available, they will be pursued by the University
      at the Sponsor's request in those countries designated by Sponsor, provided
      that
      Sponsor agrees to pay all prosecution costs associated with seeking such foreign
      patent protection. In all other events, the University may pursue foreign patent
      protection at its sole discretion.

    

    
      
        
          	
                	B.	
                  INTELLECTUAL
                    PROPERTY.

                

        

      

    

    
      
        
        

      

      
        2

        
          

        

      

      
        
        

      

    

    
      	 	
              (a)

            	
              Title
                to Inventions Based On Sponsor Information. To the extent that Sponsor
                is
                providing confidential information to the University and Principal
                Investigator, and to the extent that the Sponsor has authored the
                Protocol
                to be conducted under this Agreement, and has designed and structured
                the
                manner in which the work is to be conducted, all inventions and
                discoveries, whether or not patentable, made in the performance of
                the
                Study and that incorporates Sponsor's Study therapy, drug or device,
                including new uses (collectively, "Sponsor Inventions"), shall be
                solely
                and exclusively owned by Sponsor, and University and Principal
                Investigator hereby assign all of their right, title and interest
                in and
                to such Sponsor Inventions to Sponsor. In instances in which the
                Sponsor
                desires to secure protection on such inventions, the Principal
                Investigator will cooperate with the Sponsor, at Sponsor's expense,
                for
                the purpose of filing and prosecuting patent applications, the cooperation
                to include the execution of any and all lawful papers which may be
                deemed
                necessary or desirable by the Sponsor for the filing and prosecution
                of
                applications and for assignment of the same to the Sponsor, including
                all
                declarations, oaths, specifications, and instruments of assignment
                for
                filing and recordation in the U.S. and foreign Patent
                Offices.

            

    

    

    
      	 	
              (b)

            	
              Title
                to Other Inventions. For inventions other than Sponsor Inventions,
                title
                to any invention conceived or first reduced to practice in the performance
                of the Study ("University Inventions") shall remain with the University.
                Sponsor shall be notified of any such invention promptly after a
                disclosure is received by the University Technology Licensing Office.
                The
                University (1) may file a patent application at the request of the
                Sponsor
                and at the Sponsor's expense; or (2) may file a patent application
                at its
                own discretion.

            

    

    

    
      	 	
              (c)

            	
              Licensing
                Options. The University hereby grants to Sponsor the exclusive right
                and
                option to negotiate with the University for an exclusive, worldwide,
                right
                and license to make, have made, use and sell commercial products
                embodying
                any University Invention(s), with the right to sublicense, for the
                lives
                of any patent issuing thereon, upon commercially reasonable terms.
                The
                Sponsor and the University shall exercise reasonable efforts to agree
                to
                terms and conditions of such a license within sixty (60) days after
                Sponsor's receipt of notice and disclosure of a University Invention
                from
                the University. If, after the end of the sixty (60) day period (or
                such
                additional period if agreed by both parties), Sponsor and the University
                are unable to reach agreement on the terms of such a license, the
                University shall thereafter be free to engage in license discussions
                and
                negotiations with third parties regarding such University
                Invention(s).

            

    

    

    
      	 	
              (d)

            	
              Confidentiality
                of Invention Disclosures. The Sponsor shall retain all invention
                disclosures submitted to Sponsor by the University in confidence
                and use
                all reasonable efforts to prevent their disclosure to third
                parties.

            

    

    
      
        
        

      

      
        3

        
          

        

      

      
        
        

      

    

    
      	 	
              (e)

            	
              The
                Sponsor shall be relieved of this obligation when this information
                becomes
                publicly available through no fault of the
                Sponsor.

            

    

    

    
      	
              8.

            	
              PROPRIETARY
                DATA.
                The University's acceptance and use of any proprietary data which
                may be
                supplied by the Sponsor in the course of this research project shall
                be
                subject to the following:

            

    

    

    
      	 	
              (a)

            	
              The
                data must be marked or designated in writing as proprietary to the
                Sponsor.

            

    

    

    
      	 	
              (b)

            	
              The
                University agrees to exercise its best efforts not to publish or
                otherwise
                reveal the data to others outside the University without the permission
                of
                the Sponsor, unless the data has already been published or disclosed
                publicly by third parties or is required to be disclosed by order
                of a
                court of law.

            

    

    

    
      	 	
              (c)

            	
              The
                University shall hold proprietary information in confidence for a
                period
                not to exceed five (5) years from the termination date of this
                Agreement.

            

    

    

    
      	
              9.

            	
              USE
                OF NAMES. Neither
                party will use the name of the other in any advertising or other
                form of
                publicity without the written permission of the
                other.

            

    

    

    
      	
              10.

            	
              REPORTS.
                University
                shall provide Sponsor with interim informal reports on the progress
                of the
                Study as reasonably requested by Sponsor. A final report of the progress
                of the work shall be made to the Sponsor by the Principal Investigator
                within three months of completion of the
                Study.

            

    

    

    
      	
              11.

            	
              CHANGES.
                The Sponsor or the University may, at any time, in writing to each
                other,
                suggest and by mutual written agreement make changes within the general
                scope of the work, including but not limited
                to:

            

    

    

    
      	 	
              (a)

            	
              revising
                or adding to the work or deleting portions
                thereof,

            

    

    

    
      	 	
              (b)

            	
              revising
                the period or schedule of performance,
                or

            

    

    

    
      	 	
              (c)

            	
              increasing
                or decreasing the total cost.

            

    

    

    Upon
      receipt of such notice of change and their mutual written agreement thereto,
      the
      parties shall immediately use their best efforts to take all necessary steps
      to
      comply therewith.

    

    
      	
              12.

            	
              NOTICES.
                All
                communications, reports, and notices required or permitted hereunder
                shall
                be deemed sufficiently given if in writing and personally delivered
                or
                sent by registered mail, postage prepaid, return receipt requested,
                addressed to the parties as follows or at such other address as a
                party
                shall have given notice of pursuant
                hereto:

            

    

    
      
        
        

      

      
        4

        
          

        

      

      
        
        

      

    

     

    
      	
              If
                to the University:

            	 
	 	 	 
	          
	
              Prof.
                Dr. Carlos Alberto Garcia Oliva 

            	 
	 	
              Universidade
                Federal de Sao Paulo 

            	 
	 	
              Rua
                Botucatu 740

            	 
	 	
              04023-900,
                Sao Paulo, SP

            	 
	 	
              Brazil

            	 
	 	 	 
	 	
              Telephone:
                55 11 - 5576 4279 

            	 
	 	
              Facsimile:
                55 11 - 5576 4279

            	 
	 	 	 
	
              If
                to the sponsor:

            	 
	 	 	 
	 	
              Neurologix,
                Inc.

            	 
	 	
              One
                Bridge Plaza

            	 
	 	
              Fort
                Lee, New Jersey 07024 

            	 
	 	
              Attention:
                Mr. Mark S. Hoffman 

            	 
	 	
              Fax
                Number: 201-585-9798

            	 
	 	 	 
	
              With
                a copy to:

            	 
	 	 	 
	 	
              Neurologix,
                Inc.

            	 
	 	
              271-32
                E. Grand Central Parkway 

            	 
	 	
              Floral
                Park, NY 11005

            	 
	 	
              Attention:
                President

            	 
	 	
              Fax
                Number: (718) 747-0569

            	 

    

    

    
      	
              13.

            	
              LAWS
                AND REGULATIONS.
                This Agreement shall be governed by, and construed and enforced in
                accordance with, the Laws of the State of New York. The Sponsor shall
                cooperate with the University in complying with any applicable Federal,
                state and local laws, regulations and policies governing research.
                University represents that neither University nor any person University
                employs in performance of the Study is debarred under section 306
                of the
                United States Federal Food, Drug and Cosmetics
                Act.

            

    

    

    
      	
              14.

            	
              ASSIGNMENT.
                This
                Agreement may not be assigned by either party without the prior written
                consent of the other party. Notwithstanding the foregoing, the Sponsor
                may
                assign this Agreement without the consent of the University to a
                purchaser
                or successor-in-interest in the event of a merger, consolidation,
                or sale
                of substantially all of Sponsor's stock or assets or business and/or
                pursuant to any reorganization qualifying under section 368 of the
                Internal Revenue Code of 1986 as amended, as may be in effect at
                such
                time, provided that such successor-in-interest or purchaser agrees
                to
                assume all of Sponsor's obligations under this
                Agreement.

            

    

    
      
        
        

      

      
        5

        
          

        

      

      
        
        

      

    

    
      	
              15.

            	
              ORDER
                OF PRECEDENCE.
                The parties hereby agree, that in the event of a conflict between
                the
                terms and conditions of this Agreement, and any other document either
                incorporated by reference or attached to this Agreement, the terms
                and
                conditions of this Agreement itself shall
                prevail.

            

    

    

    
      	
              16.

            	
              ENTIRE
                AGREEMENT.
                This Agreement, including all Exhibits referenced herein, shall be
                the
                complete Agreement of the parties hereto and shall supersede all
                prior
                agreements and understandings, oral or written, between the parties
                respecting the subject matter
                hereof.

            

    

    

    The
      respective parties have executed this Agreement on the dates indicated
      below.

    

    
      	
              UNIVERSIDADE
                FEDERAL DE SAO PAULO

            	 	
              NEUROLOGIX,
                INC.

            	 
	 	 	 	 
	 	 	 	 
	
              /s/
                Ulysses Fagundes Neto

            	 	
              /s/
                Mark S. Hoffman

            	 
	
              Ulysses
                Fagundes Neto

            	 	
              Mark
                S. Hoffman

            	 
	
              Rector,
                Universidade Federal de Sao Paolo

            	 	
              Secretary
                and Treasurer

            	 
	 	 	 	 
	
              October
                20, 2004

            	 	
              Oct.
                27, 2004

            	 
	
              Date

            	 	
              Date

            	 
	 	 	 	 
	 	 	 	 

    

    

    I
      agree to act as Principal Investigator for the project described
      above:

    

    
      	
              /s/
                Prof. Luiz Eugenio A. M. Mello

            	 
	
              Prof.
                Luiz Eugenio A. M. Mello

            	 
	 	 
	 	 
	
              October
                20, 2004

            	 
	
              Date

            	 

    

     

    6Exhibit 10.19

    
      

    

     

    

      SUB
        LEASE

      
        

          
            	
                    1.

                  	
                    PARTIES

                  

          

           

          
            	 	
                    1.1

                  	
                    THIS
                      AGREEMENT, made on the 10th
                      day of August 2004 is between PALISADE CAPITAL SECURITIES,
                      L.L.C.
                      ("Sub-Lessor"), whose address is One Bridge Plaza North, Fort
                      Lee, New
                      Jersey, 07024 and Neurologix, Inc. ("Lessee"), whose address
                      is One Bridge
                      Plaza North, Fort Lee, New Jersey
                      07024.

                  

          

           

          
            	
                    2.

                  	
                    STATEMENT
                      OF FACTS

                  

          

           

          
            	 	
                    2.1

                  	
                    Sub-Lessor
                      previously entered into a Lease dated 7/1/97 and amended 12/2/02,
                      (the
                      "Lease") covering areas of 1,185 gross rentable square feet
                      on the
                      6th
                      floor (therein defined as the "Existing Premises"), and 11,222
                      gross
                      rentable square feet on the 6th
                      floor, ("Second Expansion Premises") in the building located
                      at One Bridge
                      Plaza, Fort Lee, New Jersey, ("Building"), as Lessee;
                      and

                  

          

           

          
            	 	
                    2.2

                  	
                    The
                      Term of the Lease expires on January 31, 2008;
                      and

                  

          

           

          
            	 	
                    2.3

                  	
                    Sub-Lessee
                      desires to sub-lease the 1,185 gross rentable square feet on
                      the
                      6th
                      floor (the "Existing Premises").

                  

          

           

          
            	
                    3.

                  	
                    AGREEMENT

                  

          

           

          NOW,
            THEREFORE, in consideration of the terms, covenants and conditions hereinafter
            set forth, Sub-Lessor and Sub-Lessee agree as follows:

           

          
            	 	
                    3.1

                  	
                    The
                      above recitals are incorporated herein by
                      reference.

                  

          

           

          
            	 	
                    3.2

                  	
                    A
                      copy of the Lease is attached hereto with the financial terms
                      redacted.

                  

          

           

          
            	 	
                    3.3

                  	
                    All
                      capitalized and non-capitalized terms used in this Agreement
                      which are not
                      separately defined herein but are defined in the Lease shall
                      have the
                      meaning given to any such term in the Lease. References to
                      the "Premises"
                      shall mean the Existing Premises.

                  

          

           

          
            	 	
                    3.4

                  	
                    The
                      Terms applicable to the Premises shall terminate at 11:59 P.M.
                      on January
                      31, 2008.

                  

          

           

          
            	 	
                    3.5

                  	
                    The
                      Premises shall be defined as approximately 1185 gross rentable
                      square feet
                      on the sixth (6th)
                      floor of the Building known as suite
                      #690.

                  

          

           

          
            	 	
                    a.)

                  	
                    Commencing
                      on August 1, 2004, the following shall be effective and the
                      Fixed Basic
                      Rent applicable to the Existing Premises shall be as
                      follows:

                  

          

          
             

            
              
              

            

            
              
              

              
                

              

            

            
              
              

            

          

           

          
            	 	
                    (i)

                  	
                    Commencing
                      on August 1, 2004 through the end of the term, the Fixed Basic
                      Rent for
                      the Existing Premises only shall accrue at the rate of THIRTY
                      FOUR
                      THOUSAND EIGHT HUNDRED THIRTY NINE AND 36/100 DOLLARS ($34,839.36)
                      per
                      annum, payable in advance in equal monthly installments of
                      TWO THOUSAND
                      NINE HUNDRED THREE AND 28/100 DOLLARS ($2,903.28)
                      each:

                  

          

           

          
            	 	
                    b.)

                  	
                    Sub-Lessee
                      shall pay Sub-Lessor, as Additional Rent, Sub-Lessee's Percentage
                      (9.55%)
                      applicable to the Existing Premises of the increased cost to
                      Sub-Lessor
                      for each of the categories set forth in Article 23 of the Lease
                      Additional
                      Rent over the Base Period Costs set forth
                      below.

                  

          

           

          
            	 	
                    c.)

                  	
                    Base
                      Period Costs applicable to the Existing Premises shall be as
                      follows and
                      Paragraph 2 of the Preamble to the Lease shall be deemed amended
                      accordingly:

                  

          

           

          
            	 	
                    (A)

                  	
                    Base
                      Operating Costs: Those costs incurred for the Building and
                      Office Building
                      Area for the Calendar Year 2004 or pro-rate portion thereof.
                      Notwithstanding anything above to the contrary, the Base Operating
                      Expenses for the cost of all fire and other insurance costs
                      incurred by
                      Lessor in connection with its operation and maintenance of
                      the Building
                      and Office Building Area shall be deemed to be $57,000.00 Insurance
                      shall
                      be the responsibility of sub-lessee and shall name sub-lessor
                      as
                      additional insured.

                  

          

           

          
            	 	
                    (B)

                  	
                    Base
                      Real Estate Taxes: Those Real Estate Taxes incurred for the
                      building and
                      Office Building area during the Calendar year 2004 or pro-rated
                      portion
                      thereof.

                  

          

           

          
            	 	
                    (C)

                  	
                    Base
                      Utility and Energy Costs: Those costs incurred for the Building
                      and Office
                      Building Area during the Calendar Year 2004 or pro-rata portion
                      thereof.

                  

          

           

          
            	 	
                    d.)

                  	
                    Sub-Lessee
                      shall pay Sub-Lessor the cost of electricity consumed within
                      the Existing
                      Premises in accordance with Article 22 of the Lease Building
Standard
                      Office Electrical Service.

                  

          

           

          
            	 	
                    3.6

                  	
                    Quiet
                      Possession.
                      Except as otherwise provided for in the Lease, Sub-Lessor covenants
                      and
                      agrees that so long as Sub-Lessee continues to pay rent and
                      perform its
                      obligations under this Sublease, it will have peaceable and
                      quiet
                      enjoyment of the premises.

                  

          

           

          
            	 	
                    3.7

                  	
                    Signage.
                      Subject to the approval of the Landlord as to location and
                      size,
                      Sub-Lessee shall have the right to install signage on the door
                      or adjacent
                      wall to the Premises and to list its name in the floor and
                      building
                      directories.

                  

          

           

          
            
              
              

            

            
              2

              
                

              

            

            
              
              

            

          

           

          
            	 	
                    3.8

                  	
                    Parking.
                      Sub-Lessee shall have two (2) parking spaces assigned by the
                      Sub-Lessor in
                      the building dedicated parking
                      area.

                  

          

           

          
            	 	
                    3.9

                  	
                    Cleaning.
                      The Lease is inclusive of cleaning services similar to that
                      enjoyed by
                      Sub-Lessor.

                  

          

           

          
            	 	
                    3.10

                  	
                    Sub-Lessee
                      hereby represents to the Sub-Lessor that, to the actual knowledge
                      of
                      Sub-Lessee, (i) there exists no default under the Lease either
                      by
                      Sub-Lessor or Sub-Lessee; (ii) Sub-Lessee is entitled to no
                      credit, free
                      rent or other offset or abatement of the rents due under the
                      Lease; and
                      (iii) there exists no offset, defense or counterclaim to Sub-Lessee's
                      obligation under the Lease.

                  

          

           

          
            	 	
                    3.11

                  	
                    This
                      agreement shall be binding upon and inure to the benefit of
                      the parties
                      hereto and their respective legal representatives, successors
                      and
                      permitted assigns.

                  

          

           

          
            	 	
                    3.12

                  	
                    Each
                      party agrees that it will not raise or assert as a defense
                      to any
                      obligation under the Lease or this Agreement or to make any
                      claim that the
                      Lease or this Agreement is invalid or unenforceable due to
                      any failure of
                      this document to comply with ministerial requirements including,
                      but not
                      limited to, requirements for corporate seals, attestations,
                      witnesses,
                      notarizations or other similar requirements, and each party
                      hereby waives
                      the right to assert any such defense or make any claim of invalidity
                      or
                      unenforceability due to any of the
                      foregoing.

                  

          

           

          IN
            WITNESS WHEREOF, Sub-Lessor and Sub-Lessee have hereunto set their hands
            and
            seals the date and year first above written, and acknowledged one to
            the other
            that they possess the requisite authority to enter into this transaction
            and to
            sign this Agreement.

           

          
            	
                    SUB-LESSOR:

                  	 	
                    SUB-LESSEE:

                  
	 	 	 
	
                    PALISADE
                      CAPITAL SECURITIES, L.L.C.

                  	 	
                    Neurologix,
                      Inc.

                  

          

           

           

          
            	
                    By:

                  	
                    /s/
                      Steven E. Berman

                  	 	
                    By:

                  	
                    /s/
                      Martin J. Kaplitt

                  
	 	
                    Steven
                      E. Berman

                  	 	 	
                    Martin
                      J. Kaplitt

                  
	 	
                    Chief
                      Operating Officer

                  	 	 	
                    President

                  

          

          

            3

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