Document:

Agreement on November 2, 1999

 Exhibit 10.8 
  
 PRIVATE AGREEMENT 
  
 between 
  
 GRUPPO LEPETIT S.p.A., having its registered office at Via R. Lepetit 8, Lainate (MI), Milan, Tax and VAT No. 0079596015, and Milan Companies Registry no. 22409, - in the person of its pro tempore legal
representative, 
  
 (hereinafter referred to as “ LEPETIT
”) 
  
 and 
  
 BIOSEARCH ITALIA S.p.A., having its registered office at Via Terraggio 17, Milan, Tax
and VAT No. 11922440158, and Milan Companies Registry no. 1523129, - in the person of its pro tempore legal representative 
  
 (hereinafter referred to as “BIOSEARCH”) 
  
 WHEREAS 
  

	•	On 4 December 1998 BIOSEARCH and LEPETIT entered into a private agreement whereby they agreed the basic principles governing their future relations in connection with the
development and production of propriety active ingredients and BIOSEARCH technology (hereinafter the “Deed”) 

  

	•	BIOSEARCH has asked LEPETIT whether the latter would be willing to produce for it the active ingredient A-40926 (hereinafter “A-40926”) at LEPETIT’s Brindisi plant
(hereinafter the “Plant”) using technology owned by BIOSEARCH ITALIA (hereinafter the “Technology”); 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

	•	LEPETIT has declared that is willing to perform such activities and accordingly the parties have, in keeping with the terms of the Deed, negotiated in good faith all the aspects of
the activities to be carried out; 

  

	•	now it is necessary to formalise in a specific agreement the contents of the understanding reached . 

  
 THEREFORE THE PARTIES AGREE AS FOLLOWS 
  
 ARTICLE 1 - RECITALS 
  
 The preceding recitals are an integral part of this Agreement. 
  
 ARTICLE 2 - OBJECT 
  
 BIOSEARCH appoints LEPETIT to proceed to produce A-40926 subject to the terms and conditions set forth herein. For its part LEPETIT accepts the appointment. 

 
 ARTICLE 3 - [*] LOAN 
  

	3.1	In view of the necessity to adapt the facilities at the Plant in order to proceed to production of A-40926 and in keeping with the terms of the Deed, BIOSEARCH undertakes to acquire
the equipment agreed with LEPETIT and to take responsibility for modifying and adapting the facilities required for the production process (hereinafter referred to all together as the “Equipment”), subject to joint testing of the
Equipment. 

  

	3.2	LEPETIT undertakes to follow installation of the Equipment in the Plant with its own engineering personnel. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 2 

	3.3	Further to and within the meaning of Article 1803 et seq. of the Civil Code, BIOSEARCH grants a [*] loan of the Equipment to LEPETIT which accepts. At a subsequent date the
Equipment shall be described in a separate written document which will upon its signing form an integral part of this Agreement. 

  

	3.4	The Equipment will be used at the Plant within the framework of the A-40926 production process. 

  

	3.5	LEPETIT shall maintain custody of and manage the Equipment with the care one would expect of a good father, performing all ordinary and special maintenance.

  

	3.6	Upon cessation for any reason of the relationship concerning A-40926, BIOSEARCH will retake possession of the Equipment, arranging to remove it at its own risk and expense.

  

	3.7	The [*] loan shall commence from the date of effective installation of the Equipment, as indicated in the installation report, and will terminate on the date of cessation of
relations concerning A-40926. On that date the parties may also reach an agreement in good faith on the possibility for LEPETIT to purchase the Equipment unless further relations are entertained between the parties regarding other studies and
products which will entail use of the Equipment. 

  

	3.8	In any event BIOSEARCH shall accept the return of the Equipment in the state it finds it resulting from fair wear and tear, hereby waiving any right to compensation or right to have
the Equipment returned in a pristine state 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 3 

 unless the damage thereto is connected to the clear negligence of LEPETIT. 
  

	3.9	LEPETIT shall assist in the installation of the Equipment and provide the engineering support of its own personnel or third parties as the case may be. Such service, as well as any
assistance provided by third parties (engineering companies, specialists, assemblers, etc.) must be authorised in advance by BIOSEARCH, which shall bear the full costs thereof. Any objections concerning defects (latent or otherwise) in the Equipment
or the machinery lent [*] shall be made by LEPETIT directly to the suppliers, as BIOSEARCH has made such arrangements with the latter. BIOSEARCH undertakes to ensure that the [*] lent Equipment is kept free of any charges and burdens.

  
 ARTICLE 4 - MANUFACTURING 
  

	4.1	BIOSEARCH appoints LEPETIT to proceed to utilise the technology for the production of A-40926 according to the procedure (hereinafter the “Manufacturing”) that will be the
result of activities performed in collaboration with LEPETIT for its finalisation on an industrial scale. 

  

	4.2	In accordance with Article 4 of the Deed, LEPETIT will be [*] for A-40926 and BIOSEARCH is expressly [*] of A-40926 of not less than [*] of its [*] during the period of
effectiveness of this Agreement. 

  

	4.3	LEPETIT undertakes to perform the Manufacturing fully observing the applicable laws and good manufacturing practice as well as the production licenses issued by the Ministry of
Health. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 4 

 ARTICLE 5 - LIABILITY 
  

	5.1	LEPETIT shall be liable for any loss, damage or claim of any nature arising out of or in connection with the Manufacturing and directly stemming from its activities save for cases
of force majeure and circumstances beyond the control of LEPETIT. Such liability refers solely to activities carried out or to be carried out by LEPETIT further to this Agreement. 

  

	5.2	LEPETIT shall not be liable for any loss, damage or claim where such have arisen as a result of the activities carried out or to be carried out by BIOSEARCH further to this
Agreement. 

  

	5.3	Should LEPETIT come to know of any claim and/or legal proceedings instituted with reference to A-40926, it shall timely notify BIOSEARCH accordingly in order to agree a common line
of defence. 

  

	5.4	BIOSEARCH shall be liable for any loss, damage or claim of any nature arising out of or in connection with the application of the manufacturing procedure provided to LEPETIT that
stem from shortcomings in its analysis of the risks involved in the said procedure or in the information it has given to LEPETIT. 

  
 ARTICLE 6 - SUPPLY OF TECHNOLOGY AND RAW MATERIALS 
  
 NECESSARY FOR THE MANUFACTURING 
  
 BIOSEARCH shall be obliged to supply LEPETIT information on the quantity and quality of raw materials, the specifications, the control and analysis 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 5 

 methods and the A-40926 manufacturing process. At its own risk and expense BIOSEARCH shall be obliged to supply the
technology to LEPETIT at the Plant, of which a fundamental part is the Stock of A-40926 necessary for the manufacturing. The Technology supplied shall be shall be utilised by LEPETIT exclusively for the Manufacturing. 
  
 LEPETIT for its part undertakes to directly supply all the raw materials necessary for the
Manufacturing, acquiring them from its regular suppliers or those agreed with BIOSEARCH. The costs of the raw materials will be charged by LEPETIT to BIOSEARCH at the end of each Manufacturing at effective average inventory price at the time of
their use. 
  
 ARTICLE 7 - CHECKS AND CONTROLS 

 
 Without prejudice to the provisions of specific articles of this Agreement, as regards
quality control and inspection procedures the parties will adhere to the relevant procedures used in the Plant and the methods described in the documentation furnished by BIOSEARCH. BIOSEARCH shall be entitled to carry out checks and inspections on
the Manufacturing, which LEPETIT shall permit provided they are performed during normal working hours on business days. 
  
 ARTICLE 8 - PERMITS AND AUTHORISATIONS 
  
 At its own risk and expense LEPETIT shall apply for the grant of whatever authorisations are required from an environmental and safety point of view to produce A-40926 in
compliance with the applicable laws, rules and regulations in force. Moreover, LEPETIT shall send the required communications and 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 6 

 notices concerning the production of A-40926, complying with the specific obligations imposed by the applicable
legislation. 
  
 ARTICLE 9 - CONFIDENTIALITY 
  
 The parties undertake to treat as secret and confidential all information they become aware
of from the other party during the performance of this Agreement and also agree not to use such information for purposes other than this Agreement. The parties further undertake not to disclose such information to third parties, strictly limiting
knowledge thereof to the employees involved in performing this Agreement. 
  
 The
following are exceptions to the foregoing prohibition: 
  

	1)	information which at the time of its communication is already in the public domain; 

  

	2)	information which after being communicated will enter the public domain following publication or for other reasons provided such is not a result of breach of this Agreement;

  

	3)	information which a party can prove was already in its possession prior to communication thereof by the other party and which was not obtained directly or indirectly from that other
party; 

  

	4)	information received from third parties provided such third parties have not directly or indirectly received it by virtue of a secrecy agreement. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 7 

 ARTICLE 10 - CONSERVATION OF THE STOCK AND THE A-40926 
  

	10.1	Without charging any additional fees therefor LEPETIT shall arrange to store and maintain custody of the Stock and the A-40926 produced and LEPETIT also undertakes to move it in
conformity with BIOSEARCH’s instructions. LEPETIT further undertakes to comply with all of the accounting and administrative formalities in connection with such storage and movement. 

  

	10.2	The Stock and the A-40926 stored in LEPETIT premises shall belong to BIOSEARCH and be considered as such by LEPETIT. LEPETIT will arrange for proper conservation of the Stock and
the A-40926 in accordance with instructions to be agreed upon. 

  

	10.3	The Stock and the A-40926 shall be insured by LEPETIT with a leading insurance company against all risks in connection with its storage including theft, fire and robbery.

  
 ARTICLE 11 - ORDERS 
  

	11.1	Orders 

  
 With effect from the commencement date of this Agreement, BIOSEARCH shall send LEPETIT orders for the A-40926 to be produced and delivered by LEPETIT
during the subsequent [*] period subject to availability of the production procedure and the Equipment. In order to ensure optimal planning of production, the orders shall be communicated within the [*]. The delivery dates will be agreed between the
parties. The quantity to be ordered by BIOSEARCH will be agreed from time to time taking account of the jointly agreed production yield. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 8 

	11.2	Execution of the Orders 

  
 LEPETIT shall execute the orders on the agreed delivery dates. The A-40926 produced as a result of this Agreement shall be sent by LEPETIT in accordance
with the instructions given by BIOSEARCH for each order. Any delays in delivering the A-40926 owing to transportation problems may not in any way be imputed to LEPETIT. As soon as manufacturing of the ordered quantity has been completed, LEPETIT
will immediately notify BIOSEARCH accordingly. 
  

	11.3	Forecast Volumes 

  
 Over the next [*] BIOSEARCH envisages that it will require the quantities set forth in Exhibit A hereto. In any event BIOSEARCH will give notice of [*] in
[*] (+/-[*]) or timing with respect to what is currently indicated in Exhibit A. 
  
 ARTICLE 12 - MANUFACTURING FEES AND PAYMENT TERMS 
  

	12.1	Apart from the costs of the raw materials that will be specifically charged to BIOSEARCH and be the object of separate invoicing by LEPETIT, the fee for the Manufacturing that is
the subject matter of this Agreement shall be determined as follows: 

  
 for every single Manufacturing corresponding to an entire batch of industrial [*] of [*] of total volume and about [*] of useful volume (save for any technical variations owing to the normal carrying out of the [*]
process) as well as all the activities necessary for the [*], BIOSEARCH shall pay LEPETIT the sum of ITL. [*] ([*]) plus VAT ex-Plant. Such 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 9 

 prices will at the end of each year be revised in accordance with variations in the ISTAT index or other
index that will be introduced at the effective changeover to the EURO. 
  

	12.2	In the event of significant variations in the productivity and/or yield of the Manufacturing the parties agree to renegotiate in good faith the fee under the preceding paragraph.
Should the parties fail to reach agreement on the new fee, LEPETIT shall be entitled to withdraw from this Agreement subject to giving adequate notice. 

  

	12.3	Payment of the sums under the preceding Article 12.1 shall by made by BIOSEARCH by wire transfer within sixty days from the end of the month in which the invoice is issued.

  
 ARTICLE 13 - TERM 
  

	13.1	This Agreement shall take effect from 1 January 2000 and run for a term of five years from such date 

  

	13.2	Upon expiry of the foregoing period, this Agreement will automatically renew for subsequent one year periods subject to either party’s right not to renew to be communicated in
writing to the other party by registered post (with advice of receipt) with at least one year advance notice from the expiry date. 

  

	13.3	This Agreement may be terminated immediately by either of the parties without any notice period and subject to communicating the termination by registered letter (with advice of
receipt) in the event that the other 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 10 

 party breaches any one of its obligations and fails to remedy the breach with sixty days of being
requested to do by the non-defaulting party. 
  

	13.4	BIOSEARCH shall have the right to withdraw from this Agreement subject to giving at least 18 months prior written notice in the event that one of its production units becomes
available provided it that notifies LEPETIT of such in writing by registered post (with advice of receipt). No indemnity shall be due to LEPETIT in such case. 

  

	13.5	LEPETIT shall have the right to withdraw from this Agreement subject to giving at least 18 months prior written notice, without incurring any penalty or having to pay any
compensation or indemnity to BIOSEARCH, in the event of the further unavailability of its plants necessary for the production of its own products. 

  

ARTICLE 14 - ASSIGNMENT 
  
 This Agreement may in no case be assigned or transferred by either party in whole or in part to third parties without the prior written consent of the other party.
LEPETIT shall have the right to assign this Agreement to other companies of the Hoechst Marion Roussel Group in Italy or other future group it will belong to subject to giving BIOSEARCH written notice thereof. BIOSEARCH shall have the right to
assign this Agreement to one of its production companies subject to giving LEPETIT written notice thereof. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 11 

 ARTICLE 15 - DISPUTES 
  
 The Courts of Milan shall have exclusive jurisdiction over any dispute that may arise between the parties in relation to the interpretation
and/or performance of the provisions of this Agreement. 
  
 ARTICLE 16 - CONTRACTUAL EXPENSES AND TAXATION 
  
 The parties
declare that the goods and services contemplated by this Agreement are subject to VAT and thus this Agreement will be registered at a fixed tax. 
  
 Lainate, 2 November 1999 
  

			
	 Gruppo Lepetit S.p.A.
	  	 Biosearch Italia S.p.A.

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 12 

 Quantities of A-40926 forecast for the duration of this Agreement 
  
 from 1 January 2000 to [*] 
  

			
	 YEAR

	  	 KG

	 [*]
	  	[*]
	 [*]
	  	[*]
	 [*]
	  	[*]
	 [*]
	  	[*]
	 [*]
	  	[*]

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 13Agreement on November 30, 2000

 Exhibit 10.9 
  
 PRIVATE AGREEMENT 
  
 between 
  
 GRUPPO LEPETIT S.p.A., having its registered office in Via R. Lepetit no. 8, Lainate, registered with Companies Registry of Milan under no. 22409, Tax Code and VAT no. 00795960152, in the person of its
pro-tempore legal representative 
  
 (hereinafter,
“LEPETIT”) 
  
 and 
  
 BIOSEARCH ITALIA S.p.A., having its registered office in Viale Regina Giovanna no. 17,
Milan, registered with Companies Registry of the Court of Milan under no. 1523129, Tax Code and VAT no. 11922440158, in the person of its pro-tempore legal representative 
  
 (hereinafter, “BIOSEARCH”) 
  

WHEREAS 
  

	 	•	BIOSEARCH and LEPETIT entered into a private agreement on 4 December 1998, by means of which they agreed upon the principles for their future relations concerning the production of
active ingredients owned and developed with BIOSEARCH technology and, on 8 March 1999, they entered another private agreement relating to LEPETIT’s specific production of “RAMOPLANIN” for BIOSEARCH (hereinafter, the
“Agreements”); 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

	 	•	LEPETIT, at its own Brindisi plant (the “Plant”), owns some facilities (hereinafter, the “Equipment”) and a production process, already experienced and tested at
industrial level (the “Process”) for the recovery by distillation (hereinafter, the “Recovery”) of a solvent called “Acetone”, Equipment and Process used by LEPETIT during the manufacturing process of one of its
products; 

  

	 	•	BIOSEARCH, after acknowledging the validity and effectiveness of LEPETIT’s Equipment and Process for the Recovery of Acetone, asked LEPETIT its availability to carry out on its
own the Recovery of the Acetone used for the production of Ramoplanin (hereinafter, the “Recovered Acetone”), to integrate the production of Ramoplanin already manufactured by LEPETIT in compliance with the Agreements;

  

	 	•	LEPETIT has declared that it is willing to perform such activities and therefore it is necessary to formalise in a specific agreement the contents of the understanding reached.

  
 THEREFORE THE PARTIES AGREE AS FOLLOWS

  
 ARTICLE 1 - RECITALS 
  
 The preceding recitals are an integral part of this Agreement. 
  
 ARTICLE 2 - SUBJECT MATTER 
  

	2.1	BIOSEARCH appoints LEPETIT, that accepts, to proceed to the Recovery of Acetone from the aqueous mix arising from the production of Ramoplanin, owned by BIOSEARCH, according to the
availability of 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 2 

 LEPETIT’s equipment, i.e. in the periods in which the equipment is not used by LEPETIT for its own
Recovery activities, and by using the Process. The Recovered Acetone, after its conformity with the agreed specifications (Exhibit A) has been tested, shall be used again for the production of Ramoplanin. 
  

	2.2	The cost for the disposal at third parties of waste, if any, resulting from the Recovery Process shall be charged in full to [*] and the latter shall acknowledge it in full to [*].

  

	2.3	LEPETIT undertakes to perform the Recovery of Acetone fully observing the applicable laws and good manufacturing practice as well as the production licenses required by law and
observing the technical specifications (the “Specifications”) agreed upon with BIOSEARCH. 

  
 ARTICLE 3 - CHECKS AND CONTROLS 
  
 As regards quality control and inspection procedures, the parties shall adhere to the relevant procedures used in the Plant. BIOSEARCH shall be entitled to carry out checks and inspections on the Recovery, which
LEPETIT shall permit, provided they are performed during normal working hours on business days. 
  
 ARTICLE 4 - PERMITS AND AUTHORISATIONS 
  
 At its own risk and expense, LEPETIT shall apply for the grant of whatever authorisations are required from an environmental and safety point of view to proceed to the Recovery and reuse of Acetone, in compliance with the 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 3 

 applicable laws, rules and regulations in force. Any expenses relating to such authorisations shall be charged in full to
BIOSEARCH. 
  
 LEPETIT shall send the required communications and notices
concerning the Recovery of Acetone, complying with the specific obligations imposed by the applicable legislation. 
  
 ARTICLE 5 - CONFIDENTIALITY 
  
 The parties undertake to treat as secret and confidential all information they become aware of from the other party during the performance of this Agreement and also agree not to use such information for purposes other than this Agreement.
The parties further undertake not to disclose such information to third parties, strictly limiting knowledge thereof to the employees involved in performing this Agreement. 
  
 The following are exceptions to the foregoing prohibition: 
  

	1)	information which at the time of its communication is already in the public domain; 

  

	2)	information which after being communicated will enter the public domain following publication or for other reasons, provided such is not a result of breach of this Agreement;

  

	3)	information which a party can prove was already in its possession prior to communication thereof by the other party and which was not obtained directly or indirectly from that other
party; 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 4 

	4)	information received from third parties provided such third parties have not directly or indirectly received it by virtue of a secrecy agreement. 

  
 ARTICLE 6 - STORAGE AND USE 
  

	6.1	Without charging any additional fees therefor, LEPETIT shall arrange to store and reuse the Recovered Acetone in the production of Ramoplanin in compliance with the agreements made
from time to time between the Parties and also undertakes to move it in conformity with BIOSEARCH’s instructions. It is agreed upon by the Parties that, at the end of each seasonal recovery campaign, the possible waste of the Equipment’s
storing tanks shall be sent for disposal, should any other kind of storage not be possible. At all events, subject to prior written notice of LEPETIT to BIOSEARCH of the date of change of the Recovery’s seasonal campaign, the parties shall meet
at least two months before such date, to define the operating procedures suitable to minimise the recourse to disposal of the Recovered Acetone. It is moreover expressly understood that the costs of disposal, as provided for by paragraph 2.2, shall
be charged in full to BIOSEARCH. 

  
 LEPETIT
further undertakes to comply with all of the accounting and administrative formalities in connection with such storage and movement. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 5 

	6.2	The Recovered Acetone shall belong to BIOSEARCH and be considered as such by LEPETIT. LEPETIT shall take care of its good storage, reuse or disposal according to the directions
agreed upon. 

  
 ART. 7 - ORDERS 

 
 With effect from the commencement date of this Agreement, BIOSEARCH shall send LEPETIT the
authorisation to the Recovery and reuse of Acetone to be made by LEPETIT during the subsequent [*] period subject to availability of the Equipment. LEPETIT, upon receipt of the order, shall notify BIOSEARCH of the availability of the Equipment, of
the Recovery times and of the availability of the Recovered Acetone. Any delay in the availability of the Recovered Acetone may in no way be imputed to LEPETIT, provided that it is not caused by a manifest negligence of the latter. 
  
 The Recovered Acetone shall be reused by LEPETIT according to the instructions given by
BIOSEARCH. 
  
 ART. 8 - MANUFACTURING CONSIDERATION AND PAYMENT
TERMS 
  

	8.1	The all-inclusive consideration for the Recovery of Acetone that is the subject matter of this Agreement shall be ITL [*] (=[*]) for every kilo of Recovered Acetone. Upon
introduction of the Euro as exchange currency, the above amount will be converted according to the applicable rules. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 6 

 Such amount will at the end of each solar year be revised in accordance with variations in the ISTAT
index, or different index to be introduced upon introduction of Euro as exchange currency. 
  

	8.2	In the event of significant variations in the productivity and/or yield of the Manufacturing, the parties agree to renegotiate in good faith the consideration under the preceding
paragraph. Should the parties fail to reach agreement on the new consideration, each party shall be entitled to withdraw from this Agreement subject to giving adequate notice. 

  

	8.3	The amounts under paragraph 8.1 above shall be paid by BIOSEARCH at the end of the month by bank transfer within [*] from the date of invoice. 

  
 ART. 9 - TERM 
  

	9.1	This Agreement shall take effect from 1 December 2000 until 31 December 2003, expiry date of the agreement regarding the production of Ramoplanin. 

  

	9.2	Upon expiry of the foregoing period, this Agreement will automatically renew for subsequent one year periods, together and in compliance with the automatic renewal of the agreement
regarding the production of RAMOPLANIN, unless terminated in writing by either of the parties by registered letter (with advice of receipt) with at least one year advance notice from the expiry date. 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 7 

	9.3	This Agreement may be terminated immediately by either of the parties without any notice period and subject to communicating the termination by registered letter (with advice of
receipt) in the event that the other party breaches any one of its obligations and fails to remedy the breach within sixty days of being requested to do so by the non-defaulting party. 

  

	9.4	BIOSEARCH shall have the right to withdraw from this Agreement subject to giving at least 18 months prior written notice in the event that one of its production units becomes
available provided that it notifies LEPETIT of such in writing by registered letter (with advice of receipt). No indemnity shall be due to LEPETIT in such case. 

  

	9.5	LEPETIT shall have the right to withdraw from this Agreement subject to giving at least 18 months prior written notice, without incurring any penalty or having to pay any
compensation or indemnity to BIOSEARCH, in the event of the further unavailability of the Equipment necessary for the recovery of its own Acetone. 

  

ART. 10 - ASSIGNMENT 
  
 This Agreement may in no case be assigned or transferred by either party in whole or in part to third parties without the prior written consent of the other party.
LEPETIT shall have the right to assign this Agreement to other companies of the Aventis Group in Italy, subject to giving BIOSEARCH written notice thereof. BIOSEARCH shall have the right to assign this Agreement to 

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 8 

 one of its production companies, subject to giving LEPETIT written notice thereof. 
  
 ART. 11 - DISPUTES 
  
 The Courts of Milan shall have exclusive jurisdiction over any dispute that may arise between
the parties in relation to the interpretation and/or performance of the provisions of this Agreement. 
  
 ART. 12 - CONTRACTUAL EXPENSES AND TAXATION 
  
 The parties declare that the goods and services contemplated by this Agreement are subject to VAT and thus this Agreement will be registered at a fixed tax pursuant to and in accordance with Articles 5 and 40 of
Presidential Decree no. 131 of 24 April 1986. 
  
 Lainate, 30 November 2000

  

			
	 Gruppo Lepetit S.p.A.
	  	Biosearch Italia S.p.A.

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 9 

 EXHIBIT A 
  
 Detailed list of Recovered Acetone 
  

			
	[*]	  	[*]
	 [*]
	  	 [*]

	 [*]
	  	 [*]

	 [*]
	  	 [*]

	[*]	Indicates that certain information in this exhibit has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions. 

  

 10

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