Document:

EXHIBIT 4.45
Charles Burdick Esq
c/o Telewest Communications plc
Genesis Business Park
Albert Drive
Woking
Surrey GU21 5RW

Amendment to Service Agreement

I refer to your Service Agreement dated 7 August 1997 with Telewest
Communications Group Limited (the Company) (the Agreement) and confirm that the
Board of the Company has approved the following amendments to the Agreement to
take effect as of 1 September 1998.

The Telewest Long Term Incentive Plan (the LTIP)

1.1 The Company Confirms that it provisionally agreed to make you the awards of
shares under the LTIP set out in Schedule 1 but was prevented from granting the
awards by a closed period. When the closed period has ended the Company shall
enter such arrangements and exercise its discretions under the LTIP to make you
an award which will put you in the position you would have been in had the two
awards been made in the normal course.

1.2 If an award under paragraph 1.1 above cannot be made or if the Agreement is
terminated otherwise than pursuant to clause 14.1 before the Company has made an
award under paragraph 1.1, it shall pay you a sum calculated under the
provisions of Schedule 2.

The Telewest Equity Participation Plan (the EPP)

2.1 The Company confirms that it provisionally agreed to make you an award under
the EPP on 20 March 1998 of a bonus option of 13116 shares and a matching
allocation of 13116 shares. The market value of these shares on 20 March 1998
was (pound)0.955. However, the award could not be granted at that time as it
fell in a closed period. Therefore, the Company shall enter such arrangements
and exercise its discretions under the EPP to procure that such an award is made
at expiry of the closed period.

2.2 If an award under paragraph 2.1 above cannot be made or if the Agreement is
terminated otherwise than pursuant to clause 14.1 before the Company has made an
award under paragraph 2.1, the Company shall pay you compensation on terms which
reflect the benefit you would have enjoyed had the award been made. This sum
shall be calculated according the following formula:

A = B x C x D / 36

Where:

A        is the amount of compensation;

B        is the number of shares which you would have been awarded on 20 March
         1998, had it not been a closed period;

C        is the number of months from 20 March 1998 (award date) to the date of
         termination of the Agreement; and

D        is the market value of one of the shares on the date of termination of
         the Agreement.

                                       1
<PAGE>

Annual Bonus

3. Clause 4.3 of the Agreement shall be amended to entitle you, for the calendar
year 1998, to a bonus of up to 25% of your base salary, payable within 4 months
of the end of each calendar year, upon the Company achieving target performance,
increasing pro rata to a maximum of 50% of your base salary if the Company
exceeds target performance by the parameters approved by the board of the
Company.

Stay Bonus

4. Provided that the Agreement has not been terminated and you are still
employed by the Company by the time payment under this paragraph is due, the
Company shall pay you an additional bonus, the stay bonus, up to (pound)50,000
(subject to achievement of the targets referred to below) at the same time that
all other directors' bonuses for the calendar year 1998 are paid in March 1999.
If the Company terminates the Agreement otherwise than pursuant to clause 4.1.
of the Agreement on or after 1 January 1999 but before payment under this
paragraph is made, the Company will pay you a bonus determined pursuant to this
paragraph. This payment will not rank for participation in the EPP and will not
be regarded as base pay for your pension or any other purpose. (pound)25,000 of
the payment shall be regarded as attributable to your work in successfully
arranging bank re-financing in the early part of 1998 and in respect of the
achievement of the General Cable merger planning leading to an announcement. The
remaining (pound)25,000 is subject both to satisfactory performance and to the
achievement of the following specific objectives:

o        negotiation for the exercise of pre-emption rights to acquire Cable
         London and Birmingham Cable;

o        the rights offer to shareholders and any related debt financing; and

o        the merger with General Cable.

If any or all of' these objectives are not met, the Company may still award you
up to a (pound)25,000 bonus if it considers that the objective(s) was not met
due to matters beyond your control.

Change of Control and Material Diminution in Responsibilities

5.1 A Change of Control shall occur if at any time more than 50% of the voting
rights of Telewest Communications plc for the time being should become
controlled by any third party but, for the purposes of this paragraph neither
AT&T nor Liberty Media shall be considered a third party, (Change of Control).
For the avoidance of doubt, and for the sake of clarification, a Change of
Control will not occur if shareholders of the Company enter into voting
arrangements, or sell shares, between themselves. On a Change of Control the
Agreement shall be terminable, subject always to the terms and conditions set
out in paragraph 5.2, by written notice in the 6 months following the date of
Change of Control. If such notice is given to you by the Company the notice
period shall be 24 months and, if such notice is given to the Company by you the
notice period shall be 6 months. Thereafter, the Agreement shall be terminable
upon 12 months' notice by either party.

5.2 If:

                                       2
<PAGE>

o    you give notice to the Company to terminate the Agreement under paragraph
     5.1 above between three and six months after the date of a Change of
     Control and it can be demonstrated that, in the period between Change of
     Control and the date you give notice, there has been a material diminution
     in your responsibilities compared with those you held immediately prior to
     the Change of Control; or

o    in the six months following a Change of Control the Company terminates the
     Agreement otherwise than pursuant to clause 14.1 of the Agreement;

then, in either case, the Company will pay to you within 7 days after the
termination of the Agreement a single lump sum equal. to the aggregate of:

(i)      twice your basic annual salary at the date of termination; and

(ii)     the aggregate of:

          o    the annual premium payable by the Company to provide the medical
               expenses insurance in clause 7.1(a) of the Agreement;

          o    the annual value to you of the company car provided to you under
               clause 8.1 of the Agreement calculated by the Company in
               accordance with the Automobile Association's tables current at
               the date of termination; and

          o    the annual value of other benefits to which you are entitled at
               the date of termination as set out on the last form P11D returned
               to the Inland Revenue in respect of your employment.

Termination

6. If the Agreement is terminated by you on a Change of Control (in
circumstances where there has been a diminution in your responsibilities as
described in paragraph 5.2) or by the Company after a Change of Control on or
before 3 1 December 1998:

6.1 the Company will pay you within 7 days after the termination the amounts
payable, if not already paid, under paragraph 4 above ((pound)50,000), subject
to the targets referred to being satisfied, so far as possible, in the period to
the termination of the Agreement;

6.2 the Company will pay you a pro rata bonus from the commencement of the then
current bonus year up to the date of termination [to be calculated by reference
to the average bonus received by the other executive directors in that year] and
to be paid on the date when other executive directors receive their bonuses in
respect of that year.

Liquidated damages

7. Clause 1.3 of the Agreement shall be replaced by the following clause:

1.3 The Company shall satisfy its obligations to give a period of notice under
Clause 1.2 by terminating the employment of the Executive no later than seven
days after the date it gives notice and paying to the Executive salary and a sum
equal to the value to him of (a) any outstanding guaranteed bonus and (b) the
other benefits to which he is entitled pursuant to Clauses 4, 5, 7 and 8 or
otherwise in lieu of notice.

Expenses

                                       3
<PAGE>

8. A new clause 10.1(d) shall be included in the Agreement as follows:

(d)  one business class return air fare per year between the United Kingdom and
     the United States of America for the Executive, his spouse and children
     below the age of 18 years.

Taxation

9. All payments made by the Company under the Agreement as amended by this
letter shall be made less tax and other deductions required by law.

Acceptance

Please signify your approval and acceptance of these amendments by signing both
of the enclosed copies of this letter, retain one and return the other to me.

Yours sincerely

/s/ Telewest Communications plc

For and on behalf of the Company

I agree to the terms set out above.

/s/ Charles Burdick                         14-10-98

CHARLES BURDICK                             Date

                                       4
<PAGE>

                                   SCHEDULE 1

                      The Telewest Long Term Incentive Plan
<TABLE>
<CAPTION>
------------------------------------ -------------------------------- --------------------------------------------
Date of Award                        Number of Shares                        Proportion of Relevant Shares
------------------------------------ -------------------------------- --------------------------------------------
<S>                                  <C>                                                <C>
November 1997                        264910                                             Y/36ths
------------------------------------ -------------------------------- --------------------------------------------
March 1998                           244565                                             Z/36ths
------------------------------------ -------------------------------- --------------------------------------------
</TABLE>

                                       5
<PAGE>

                                   SCHEDULE 2

Definitions

Allocation means a promise to transfer shares in the Company in accordance with
the rules of the Plan;

Company means Telewest Communications plc (for the purposes of this Schedule);

Executive means Charles Burdick;

Notice of Exercise means a notice substantially in the form set out in Appendix
2 to this Schedule.

Participant means a person who has been given an Allocation under the Plan;

Payments means the cash payments or Shares representing a value equal to such
cash payments, set out in paragraphs 1 and 2 below or either of them;

Performance Period means:

(a)      in respect of the Payment payable under paragraph 1 below, 1 January
         1997 to 31 December 1999;

(b)      in respect of the Payment payable under paragraph 2 below, 1 January
         1998 to 31 December 2000;

Plan means the Telewest Long Term Incentive Plan;

Remuneration Committee means the Remuneration Committee of the Company.

Shares means Shares in the Company

1. Within 10 working days of the service of a Notice of Exercise by the
Executive (which may not be served before 31 December 1999 or after 31 January
2000) the Company shall pay the Executive a cash sum or, at the election of the
Remuneration Committee, transfer Shares equal in value to such cash sum, subject
to paragraphs 3 to 8 below, calculated in accordance with. the following
formula:

         A x B x Y = 36
                 -
                 36

Where:

         A is the number of allocated Shares under the Plan;

         B is the Company's middle market share price (per Share) either:

         o        at the close of business on the date immediately preceding the
                  date on which a Notice of Exercise is served or, where
                  appropriate, an event within paragraph 4 below occurs; or

         o        at the close of business on the tenth working day preceding
                  the date of payment to the personal representatives under
                  paragraph 7 below.

                                       6
<PAGE>

         C is the product of A x B x Y in cash or Shares, the value of which at
                                     -
                                     36

         the close of business on the date of valuation referred to in this
         paragraph is equal to such cash sum. In the event that the cash sum
         cannot be represented by a whole number of Shares, the number of Shares
         shall be rounded up to the next whole number.

         Y is the whole number of calendar months between 1 January 1997 and the
         date of termination of the Service Agreement dated 7 August 1997, made
         between the Executive and Telewest Communications Group Limited.

2. Within 10 working days of the service of a Notice of Exercise by the
Executive (which may not be served before 31 December 2000 or after 31 January
2001) the Company shall pay the Executive a cash sum or, at the election of the
Remuneration Committee, transfer Shares equal in value to such cash sum, subject
to paragraphs 3 to 8 below, calculated in accordance with the following formula:

         D x E x Z = F
                 -
                 36

         Where:

         D is the number of allocated Shares under the Plan;

         E is the Company's middle market share price (per Share) either:

         o        at the close of business immediately preceding the date on
                  which a Notice of Exercise is served, or where appropriate,
                  the occurrence of an event within paragraph 4 below occurs;

         o        at the close of business on the tenth working day preceding
                  the date of payment to the personal representatives under
                  paragraph 7 below.

         F is the product of D x E x Z in cash or Shares, the value of which at
                                     -
                                    36

         the close of business on the date of valuation referred to in this
         paragraph is equal to such cash sum. In the event that the cash sum
         cannot be represented by a whole number of Shares, the number of Shares
         shall be rounded up to the next whole number.

         Z is the whole number of calendar months between 1 January 1998 and the
         date of termination of the Service Agreement dated 7 August 1997, made
         between the Executive and Telewest Communications Group Limited.

3. Except where paragraph 4 below applies, such percentage of the Payments set
out in paragraphs 1 and 2 above shall be paid as the conditions in Appendix 1 to
this Schedule provide (Relevant Payments).

4. If any person obtains control of the Company (within the meaning of section
840 of the Income and Corporation Taxes Act 1988) as a result of making a
general offer to acquire shares in the Company or having obtained such control
makes such an offer, or if any person becomes bound or entitled to acquire
shares in the Company under sections 428 to 430F of the Companies Act 1985, or
if under section 425 of the Companies Act 1985 the Court sanctions a compromise
or arrangement proposed for the purposes of or in connection with a scheme for
the reconstruction of the Company or its amalgamation with any other company or
companies, or if the Company passes a resolution for voluntary winding up, or if

                                       7
<PAGE>

an order is made for the compulsory winding up of the Company the Payments shall
be made in full to the Executive within 10 working days thereof (subject always
to paragraph 8 below).

5. For the purposes of paragraph 4 above, a person shall be deemed to have
obtained control of the Company if he and others acting in concert with him have
together obtained control of it.

6. In the event of any increase or variation of the share capital of the Company
(whenever effected), the Remuneration Committee may adjust the Payments as it
considers appropriate but in a manner consistent with any adjustment made to the
entitlements of at least a majority of the Participants in the Plan. As soon as
reasonably practicable after making any such adjustment the Company shall give
notice in writing to the Executive at his last known address.

7. If the Executive dies after the end of the relevant Performance Period but
before either or both of the Payments are paid, the outstanding Relevant
Payments shall be paid to the Executive's personal representatives as soon as
practicable following the death of the Executive. If the Executive dies before
the end of either of the Performance Periods, the Relevant Payments shall not be
made before the end of the respective Performance Periods.

8.1 Where the Payment is a cash sum, the Company shall withhold or make
necessary deductions from the Payment in respect of any tax or social security
contribution it is required to deduct from any such. payment:

8.2 Where the Payment is a transfer of Shares and the Company is obliged to
account for any tax and/or any social security contributions recoverable from
the Executive (together, the Tax Liability) for which the Executive is liable by
virtue of being entitled to the transfer of Shares, the Company shall not be
obliged to transfer the Shares, unless either it has received on or prior to the
transfer of the Shares payment from the Executive of an amount not less than the
Tax Liability, or the Executive has entered into arrangements reasonably
acceptable to the Company to secure that such a payment is made.

9. In the event of any dispute or disagreement as to the interpretation of this
Schedule, or as to any question or right arising from or related to this
Schedule, the decision of the Remuneration Committee shall be final and binding
provided that it is accepted that any entitlement pursuant to this Schedule
shall be generally no less favourable (other than in relation to the proportion
of Relevant Shares applicable) than that of the majority of the Participants in
the Plan.

10. Any alterations made pursuant to Rule 7 of the Plan shall also be made to
the terms of this Schedule, where relevant.

                                       8
<PAGE>

                                   APPENDIX 1

                            The Schedule to the Plan

PART A

1.       For the purposes of this Appendix:

(a)      TSR means total shareholder return, calculated by Datastream after:

         (i)      reinvesting dividends (plus associated tax credits) on a
                  company's shares on the day on which the shares went
                  ex-dividend on the London Stock Exchange;

         (ii)     making such adjustments to take account of any increase or
                  variation of the share capital of a company as the
                  Remuneration Committee considers relevant; and

         (iii)    averaging the index of closing share prices and reinvested
                  dividends for the period of three months preceding the
                  Performance Period and averaging the index of closing share
                  prices and reinvested dividends for the final. three months of
                  the Performance Period.

(b)      the FT-SE 100 Index means the Financial Times - Stock Exchange index of
         the market values of 100 leading UK equities;

(c)      the Comparator Companies means the group of companies set out in Part B
         of this Appendix (or such other such group of companies as the Board
         may decide from time to time before a Payment is made, taking into
         account any factors considered by the Board to be relevant);

(d)      the Relevant FT-SE 100 Companies means the companies which were the
         constituent companies for the purposes of the FT-SE 100 Index at the
         commencement of the Performance Period in question and, if it was not
         such a company, the Company;

(e)      the Relevant Comparator Companies means the Company and the Comparator
         Companies which were listed on the London Stock Exchange at the
         commencement of the Performance Period in question;

(f)      any reference to the Company's position is a reference to what would be
         its position in a table of the Relevant FT-SE 100 Companies or a table
         of the Relevant Comparator Companies arranged in descending order
         according to the TSR of each of them for the Performance Period;

(g)      in the event that one of the Relevant FT-SE 100 Companies or one of the
         Relevant Comparator Companies is taken over, the TSR of that company
         shall be calculated up to the date of change of control (within the
         meaning of section 840 of the Income and Corporation Taxes Act 1988) of
         that company on the basis that:

         (i)      if the takeover is on terms that an offer wholly or partly in
                  cash is made to shareholders, that cash is assumed to have
                  been reinvested in the FT-SE 100 Index for the balance of the
                  Performance Period;

         (ii)     if the takeover is on terms that it is compulsory for part or
                  all of the offer to be satisfied in the form of shares, those
                  shares are assumed to be held until the end of the Performance
                  Period.

                                       9
<PAGE>

(h)      in the event of a demerger of one of the Relevant FT-SE 100 Companies
         or one of the Relevant Comparator Companies into two or more companies
         quoted on a recognised stock exchange (within the meaning of that term
         as set out in section 841 of the Income and Corporation Taxes Act
         1988), the TSR of the relevant company will be calculated by
         aggregating the total shareholder return of the demerged company or
         companies and the company from which it or they demerged for the part
         of the Performance Period following the demerger become effective.

2. If one of the events specified in paragraph 4 of Schedule 4 of this Agreement
occurs, for the purposes of the calculation of TSR the middle-market quotation
of the Relevant FT-SE 100 Companies or the Relevant Comparator Companies on such
date shall be taken as the final share price of such companies (and the final
share price shall not be averaged) and the final share price of the Company
shall be taken as the most valuable option offered to shareholders in the
Company as at the date of such event.

3. The percentage of the Payment, when TSR is measured against the Relevant
FT-SE 100 Companies, is as follows:

(a)      50% of the Payment if the Company is in the 25th (or a higher)
         position;

(b)      12 1/2% of the Payment if the Company is in the 50th position;

(c)      0% of the Payment if the Company is in the 51st (or a lower) position;

and pro rata for positions between those specified at (a) and (b) above.

4. The percentage of the Payment, when TSR is measured against the Relevant
Comparator Companies, is as follows:

(a)      50% of the Payment if the Company has an upper quartile position;

(b)      12 1/2% of the Payment if the Company is at the median position (or if
         there is no median position, the position immediately above the median
         position);

(c)      0% of the Payment if the Company is below the median position;

and pro rata for positions between those specified at (a) and (b) above.

5. The Remuneration Committee may make such adjustments to the method of
calculating TSR or any other feature of this Appendix as it considers
appropriate to ensure that the condition in this Appendix achieves its original
purpose.

PART B

List of Comparator Companies

British Telecommunications plc
Vodafone Group plc
Orange plc
General Cable plc
British Sky Broadcasting Group plc
Flextech plc
Eurotunnel plc
Comcast Corp

                                       10
<PAGE>

Nynex Corporation
International CabelTel Corp
Carlton Communications plc
Yorkshire Tyne Tees Television Holdings plc
HTV Group plc
Scottish Television plc

                                       11
<PAGE>

                                   APPENDIX 2

                               NOTICE OF EXERCISE

                                                                    Mr C Burdick
                                                                       [Address]

The Directors
Telewest Communications plc Genesis Business Park
Albert Drive
Woking
Surrey GU21 5RW

Dear Sirs

LETTER DATED [        ] (THE LETTER)

Pursuant to paragraph [1] [2] and subject to any deduction pursuant to paragraph
8 of Schedule 2 to the Letter I hereby serve a Notice of Exercise with the
effect that you shall make the Relevant Payments to me by cheque or by delivery
of Shares, such cheque or Shares to be received by me not later than 10 working
days of the date of this notice.

Yours faithfully

CHARLES BURDICK

                                       12Exhibit
10.28

 

February 5, 2002

 

Dr. Michael Perry

10010 Sundial Lane

Beverly Hills, California
90210

 

Dear Mike,

 

On behalf of Pharsight Corporation (“Pharsight” or the “Company”), I am
pleased to offer you the position of President and Chief Executive Officer on
the terms described below.  We are
convinced that by combining your outstanding experience in drug development,
leadership stature in the pharmaceutical industry, and demonstrated management
capability, with our current organizational strengths, proven technology, and
established customer base, you will catalyze tremendous value for yourself and
all Pharsight shareholders.  Further, we
believe that the support of our world-class board of directors will significantly
enhance your success in this significant career step—your first assignment as
CEO of a publicly traded company.

 

Reporting
Relationship, Salary, Annual Bonus and Benefits:

 

In this position you will report to the Company’s Board of Directors
(the “Board”).  Your annual base salary
will be $320,000, and will be paid semi-monthly on the Company’s normal payroll
schedule.   In FY2002 (begins April 1,
2002) you are eligible to participate in an incentive annual bonus program
targeted at 65 percent of your annual base salary, with a total compensation
potential (if you earn the target bonus of 65 percent) of $528,000.  Your annual bonus will be governed by the
terms and conditions of the Company’s management incentive plan, as
administered by the Company’s Compensation Committee, including a cap on bonus
payments at 160 percent of target in the event of overachievement of plan.  In addition, you will be eligible for
Pharsight’s regular employee benefits programs, including health, dental, life
and disability insurance, 401(k) plan and an annual accrual of 20 paid personal
time-off days.

 

Sign-On and Retention Bonus

 

In order to ensure your
ability to join us at the earliest possible date, and provided you commence
full time employment no later than February 25, 2002, you will be eligible for
a one time sign-on and retention bonus of cash and stock valued at a total of
approximately $340,000 which will be paid as follows:  1/3 of the bonus will be paid as a cash bonus of $113,000
(subject to taxes and withholdings) during the first pay period following your
first day of employment; another 1/3 of the bonus will be paid as a cash bonus
of $113,000 (subject to taxes and withholdings) on the first anniversary of
your hire date; and the remaining 1/3 of the sign-on bonus will be provided in
the form of a stock grant of Pharsight Common Stock valued at approximately
$114,000 (valuation is based on the fair market value of the stock on the date
of grant).  The stock grant will be
issued promptly by the Compensation Committee after your hire date, and the grant
will placed into and 

 

 

 

held in escrow for a
period of 18 months.  In addition, if
you voluntarily terminate your employment prior to 12 months following your
hire date, you will forfeit the pro-rated shares of the stock grant which will
be released to the Company (pro-rated based on your termination date), and the
cash portion of the bonus previously paid to you will be immediately due and
payable to Pharsight Corporation according to the following schedule (which the
Company can deduct from any amounts owed to you):

 

 

	
   

  	
  Termination date:

  	
   

  	
  Portion of Cash Bonus and Stock Grant Owed to
  Company:

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
  1-90
  days after hire

  	
   

  	
  100%

  	
   

  
	
   

  	
  91-180
  days after hire

  	
   

  	
  70%

  	
   

  
	
   

  	
  181-365
  days after hire

  	
   

  	
  40%

  	
   

  
	
   

  	
  After
  1 year

  	
   

  	
  0%

  	
   

  
						

 

Stock
Option Grant

 

In addition, I will recommend to the Board that you be granted an
option to purchase 700,000 shares of Pharsight Common Stock (the
“Option”).  The Option will vest over
four years during your continued employment (25 percent of the shares vesting
after one year of employment, with the remaining 75 percent of shares vesting
in equal installments on a monthly basis thereafter over the following three
years), and will be subject to the terms and conditions of the Company’s 2000
Equity Incentive Plan (the “Plan”) and your grant agreement.  The exercise price of the Option will be the
fair market value of the stock as determined by the closing price on the
business day immediately preceding the day you start work as an employee of
Pharsight.  In the event of a change of
control (as defined in the Plan), 50 percent of your remaining unvested Option
shares will vest immediately.  In the
event that your employment is terminated without Cause (as defined below) as a
direct result of and within twelve (12) months following such a change of
control, the remainder of your unvested Option shares will vest.  Your performance and compensation will be
reviewed annually, after the completion of each fiscal year.  Based on your performance and other factors
considered by the Compensation Committee, you will be eligible to receive
further stock option grants at the sole discretion of the Compensation
Committee.

 

Relocation
To Bay Area and Living Expenses

 

As we discussed, we expect that you will relocate to the San Francisco
Bay Area within six (6) months after your hire.  To assist in your relocation, upon your submission of appropriate
documentation (including receipts) and in accordance with the Company’s expense
reimbursement policies and practices, Pharsight will reimburse you for your
reasonable relocation expenses, up to a maximum reimbursement aggregate amount
of $200,000.

 

Prior to your relocation to the Bay Area, Pharsight will reimburse you
for your reasonable and necessary living expenses while in the Bay Area, upon
your submission of appropriate documentation (including receipts) and in
accordance with the Company’s expense reimbursement policies and
practices.  For example, at its
election, the Company will either provide you with 

 

 

 

corporate rental housing for your use in the Bay Area, or will
reimburse you for your reasonable local rental housing costs.  In addition, prior to your relocation to the
Bay Area, the Company will reimburse you for your out-of-pocket costs to fly
(coach or business class) between the Bay Area and Southern California as required, upon your submission of
appropriate documentation (including receipts).  You agree to book such flights as far in advance as possible in
order to obtain the lowest available fares.

 

Severance Payments

 

In the event that your employment is involuntarily terminated without
Cause (as defined below), the Company will continue to pay your base salary in
effect on the termination date for one (1) year following the termination date
as your sole severance benefits (the “Severance Payments”).  As a condition of your receipt of the
Severance Payments, you must first enter into a separation agreement with the
Company that includes your general release of claims, in a form acceptable to
the Company.  The Severance Payments
will be paid on the Company’s normal payroll schedule and will be subject to
standard deductions and withholdings.

 

For the purposes of this letter, “Cause” for your termination shall
mean:  (a) your conviction of any
felony or of any crime involving dishonesty; (b) your participation in any
fraud or act of dishonesty against the Company; (c) the material breach of
your duties to the Company, including persistent unsatisfactory performance of
job duties; (d) your intentional damage to, or willful misappropriation
of, any property of the Company; (e) your material breach of any written
agreement with the Company (including this letter agreement); or (f) conduct
that in the good faith and reasonable determination of the Company’s Board
demonstrates gross unfitness to serve.

 

Company Policies and Procedures;
Proprietary Information and Inventions Agreement

 

As a Pharsight employee, you will be expected to abide by Pharsight’s
policies and procedures, as may be in effect from time to time, and to
acknowledge in writing that you have read Pharsight’s Employee Handbook.  As a condition of your employment with
Pharsight, you will be required to sign and abide by the Company’s Proprietary
Information and Inventions Agreement, two originals of which are enclosed.  Please sign both originals and return one to
me with your acceptance of this offer.

 

At-Will Employment Relationship

 

Your employment
relationship with Pharsight will be at-will. 
This offer does not constitute a guarantee of employment for any
specific period of time, and either you or Pharsight may terminate the
employment relationship at any time, with or without cause or advance notice.

 

Miscellaneous

 

This letter, together with your Proprietary Information and Inventions
Agreement, forms the complete and exclusive statement of your employment
agreement with Pharsight.  It supersedes
any other agreements or promises made to you by anyone, whether oral or
written, and it cannot be 

 

 

 

modified except in a written agreement signed by you and a duly
authorized officer of Pharsight.  As
required by law, this offer is subject to satisfactory proof of your right to
work in the United States.

 

I am personally excited by the opportunity to work with you to build a
great business while implementing our shared vision for the pharmaceutical
industry. We look forward to having you join us and expect your employment with
Pharsight to begin on or before February 25, 2002.  Please sign the enclosed copy of this offer letter to indicate
your acceptance of the Company’s offer under the above terms and return it to
me by Friday, February 8, 2002.

 

Sincerely,

 

 

 

Arthur Reidel

Chairman of the Board

 

	
  AGREED AND ACCEPTED:

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  Dr. Michael Perry

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  Date

  	
   

  

 

Enclosure:  Proprietary
Information and Inventions Agreement

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