Document:

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                                                                   EXHIBIT 10.19

          Confidential Materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

                         CO-EXCLUSIVE LICENSE AGREEMENT

between

Garching Innovation GmbH,
Hofgartenstrasse 8, 80539 Munchen, Germany,
represented by the Managing Director, Dr. Bernhard Hertel,
- as licensor, hereinafter called "GI"-

and

Alnylam Pharmaceuticals Inc.,
790 Memorial Drive, Suite 202, Cambridge, MA 02139, USA
represented by the Chief Executive Officer, John Maraganore,
 - as licensee, hereinafter called "COMPANY" -

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PREAMBLE

WHEREAS, Massachusetts Institute of Technology ("M.I.T."), Whitehead Institute
for Biomedical Research ("WHITEHEAD"), Max-Planck-Gesellschaft zur Foerderung
der Wissenschaften e.V. ("MAX-PLANCK") and University of Massachusetts
("UMASS"), are joint owners of certain JOINT PATENT RIGHTS (as later defined
herein) relating to "RNA Sequence-Specific Mediators of RNA Interference", by
David P. Bartel, Phillip A. Sharp, Thomas Tuschl, and Phillip D. Zamore
(MAX-PLANCK Case No. GI 2716 KTM).

WHEREAS, MAX-PLANCK is the owner of certain MAX PLANCK PATENT RIGHTS (as later
defined herein) relating to "RNA Interference Mediating Small RNA Molecules," by
Thomas Tuschl, Sayda Elbashir and Winfried Lendeckel (MAX-PLANCK Case No. GI
2782 KTM).

WHEREAS, M.I.T., WHITEHEAD, MAX-PLANCK and UMASS have the right to grant
licenses under the JOINT PATENT RIGHTS and the MAX PLANCK PATENT RIGHTS, subject
to a royalty-free, nonexclusive license granted to the United States and the
German Governments to practice the JOINT PATENT RIGHTS and the MAX PLANCK PATENT
RIGHTS for government purposes.

WHEREAS, MAX-PLANCK has authorized Garching Innovation GmbH ("GI") to act as its
agent for the purposes of licensing its ownership position of JOINT PATENT
RIGHTS and the MAX PLANCK PATENT RIGHTS.

WHEREAS, WHITEHEAD, M.I.T. and UMASS have not authorized GI to act as their
agent for the purposes of licensing the JOINT PATENT RIGHTS and the MAX PLANCK
PATENT RIGHTS for therapeutic purposes, and therefore, this Agreement is not
binding on each of WHITEHEAD, M.I.T. and UMASS unless and until it gives its
respective individual approval.

WHEREAS, COMPANY is an early-stage therapeutics company which was founded in
2002 by an international group of scientists that helped discover the novel
biological phenomenon of RNA interference.

WHEREAS, COMPANY desires to obtain one co-exclusive license, with the right to
grant sublicenses, under the JOINT PATENT RIGHTS and the MAX PLANCK PATENT
RIGHTS for the purpose of developing and commercializing therapeutic products,
and GI desires to grant such license on the terms and conditions hereinafter set
forth.

WHEREAS, the shareholders of COMPANY desire to found and finance EuropeRNAi (as
later defined herein) under certain REQUIREMENTS (as later defined herein) as an
European-based therapeutics company.

WHEREAS, GI intends to grant to EuropeRNAi, upon fulfillment of the
REQUIREMENTS, one

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additional co-exclusive license, with the right to grant sublicenses, under the
JOINT PATENT RIGHTS and the MAX PLANCK PATENT RIGHTS for the purpose of
developing and commercializing therapeutic products.

NOW, THEREFORE, GI and COMPANY hereby agree as follows:

ARTICLE 1 - DEFINITIONS

1.1      "JOINT PATENT RIGHTS"

shall mean:

(a)      the United States and international patent and provisional applications
         listed on Appendix A and the resulting patents,

(b)      any patent applications resulting from the provisional applications
         listed on Appendix A, and any divisionals, continuations,
         continuation-in-part applications, and continued prosecution
         applications (and their relevant international equivalents) of the
         patent applications listed on Appendix A and of such patent
         applications that result from the provisional applications listed on
         Appendix A, to the extent the claims are directed to subject matter
         specifically described in the patent applications listed on Appendix A,
         and the resulting patents,

(c)      any patents resulting from reissues, reexaminations, or extensions (and
         their relevant international equivalents) of the patents described in
         (a) and (b) above, and

(d)      international (non-United States) patent applications and provisional
         applications filed after the EFFECTIVE DATE and the relevant
         international equivalents to divisionals, continuations,
         continuations-in-part applications and continued prosecution
         applications of the patent applications to the extent the claims are
         directed to subject matter specifically described in the patents or
         patent applications referred to in (a), (b), and (c) above, and the
         resulting patents.

1.2      "MAX PLANCK PATENT RIGHTS"

shall mean:

(a)      the United States and international patent and provisional applications
         listed on Appendix B and the resulting patents,

(b)      any patent applications resulting from the provisional applications
         listed on Appendix B, and any divisionals, continuations,
         continuation-in-part applications, and continued prosecution
         applications (and their relevant international equivalents) of the
         patent applications listed on Appendix B and of such patent
         applications that result from the provisional applications listed on
         Appendix B, to the extent the claims are directed to subject matter
         specifically described in the patent applications listed on Appendix B,
         and the resulting patents,

(c)      any patents resulting from reissues, reexaminations, or extensions (and
         their relevant international equivalents) of the patents described in
         (a) and (b) above, and

(d)      international (non-United States) patent applications and provisional
         applications filed after

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         the EFFECTIVE DATE and the relevant international equivalents to
         divisionals, continuations, continuations-in-part applications and
         continued prosecution applications of the patent applications to the
         extent the claims are directed to subject matter specifically described
         in the patents or patent applications referred to in (a), (b), and (c)
         above, and the resulting patents.

1.3      "PATENT RIGHTS"

shall mean the JOINT PATENT RIGHTS and MAX PLANCK PATENT RIGHTS together.

1.4      "OWNERS"

shall mean M.I.T., WHITEHEAD, UMASS and MAX-PLANCK collectively.

1.5      "LICENSED PRODUCTS"

shall mean any product or part thereof the manufacture, use or sale of which
would, absent the license granted hereunder, infringe one or more issued claims
of the PATENT RIGHTS or one or more pending claims of the PATENT RIGHTS that
have not been pending for more than 5 (five) years after filing national patent
applications in the country in question.

1.6      "FIELD"

shall mean all uses other than the commercial sale or use of the LICENSED
PRODUCTS as a research reagent, including in a kit format, for research or
educational purposes, including without limitation,

(i) COMPANY'S internal and collaborative research use, and

(ii) all therapeutic and prophylactic uses, and

(iii) diagnostic uses for purposes of therapeutic monitoring, but excluding all
other diagnostic uses,

specifically including human and veterinary diseases, initially for all
indications, but with a later split of indications according to Section 2.3.

1.7      "SUBLICENSEE"

shall mean any third party who sells or intends to commercialize LICENSED
PRODUCTS under a sublicense from COMPANY to develop, make, use and sell LICENSED
PRODUCTS. SUBLICENSEE shall not include a distributor which purchases LICENSED
PRODUCTS (whether in packaged form or bulk form) from COMPANY and resells such
LICENSED PRODUCTS to third parties in a manner consistent with normal trade
practices in the pharmaceutical industry.

1.8      "NET SALES"

shall mean the gross amount invoiced by COMPANY and its SUBLICENSEES to third
parties for LICENSED PRODUCTS, less the following: (i) to the extent separately
stated on the document of sale, [**] LICENSED PRODUCTS which are paid by
COMPANY, (ii) [**], (iii) [**], and (iv) [**]. No deductions shall be made for
[**]. NET SALES shall occur on the date of invoice for a

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LICENSED PRODUCT.

Non-cash consideration shall not be accepted by COMPANY or any SUBLICENSEE for
LICENSED PRODUCTS without the prior written consent of GI.

In the event that a LICENSED PRODUCT is sold in combination with one or more
active ingredients (excluding, without limitation, any formulation,
stabilisation and delivery technology) which are not LICENSED PRODUCTS, which
active ingredients are also independently marketed during the royalty period in
question in the FIELD (or the non-exclusive field licensed in the second
paragraph of Section 2.1, as the case may be) in the country in question, then
NET SALES, for purposes of determining royalty payments on the combination
product, shall be calculated by multiplying the NET SALES of the combination
product by the fraction A/A+B, where A is the average gross selling price of the
LICENSED PRODUCT sold separately in similar quantities in the country in
question during the royalty period in question, and B is the average gross
selling price of the other active ingredient(s) sold separately in similar
quantities in the country in question during the royalty period in question. In
the event that a LICENSED PRODUCT is sold in combination with other active
ingredient(s), and the LICENSED PRODUCT or one or more other active ingredients
are not sold separately, GI and COMPANY shall negotiate in good faith other
means of calculating NET SALES with respect to such combination product, in
order to fairly reflect the value of the LICENSED PRODUCT relative to the other
active ingredient(s) in such combination product.

1.9      "REQUIREMENTS"

shall mean the requirements listed on Appendix C for EuropeRNAi.

1.10     "EuropeRNAi"

shall mean the European-based therapeutics company founded and established
according to the REQUIREMENTS.

1.11 "EFFECTIVE DATE"

shall mean the date of signature to this Agreement by the party last to sign.

1.12     "TERM"

shall mean the term of this Agreement, which shall commence on the EFFECTIVE
DATE and shall remain in effect until the expiration or abandonment of all
issued patents and filed patent applications within the PATENT RIGHTS, unless
earlier terminated in accordance with the provisions of this Agreement.

                                                      Alnylam; GI 2716, 2782 ZTM
                                                           Dec. 19, 2002; page 5

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ARTICLE 2 - GRANT OF RIGHTS

2.1      License Grant

GI grants to COMPANY for the TERM a worldwide royalty-bearing co-exclusive
license, with the right to grant sublicenses, under the PATENT RIGHTS to
develop, make, have made, use, sell and import LICENSED PRODUCTS in the FIELD.

GI grants to COMPANY for the TERM a worldwide royalty-bearing non-exclusive
license, without the right to grant sublicenses, under the PATENT RIGHTS to
develop, make, have made, use, sell and import LICENSED PRODUCTS for all
diagnostic uses other than for purposes of therapeutic monitoring.

2.2      Co-Exclusivity

GI and the approving OWNERS (according to Appendix D) shall not grant more than
a total of [**] (including the license granted hereby) worldwide royalty-bearing
co-exclusive licenses, with the right to grant sublicenses, under the PATENT
RIGHTS to develop, make, have made, use, sell and import LICENSED PRODUCTS in
the FIELD, and shall not grant any licenses under the PATENT RIGHTS in the FIELD
other than such [**] licenses.

This Section 2.2 shall not apply to the non-exclusive license stated in the
second paragraph of Section 2.1.

2.3      Split of Indications within the FIELD

[**] years after the EFFECTIVE DATE, COMPANY shall provide GI with information
in sufficient detail for each relevant indication and sub-indication within the
FIELD with respect to the estimated market size and accessibility by RNAi. If GI
decides, for good reason, that the received information is not complete and/or
not accurate and/or not sufficient, GI shall give COMPANY written notice thereof
within [**] after receiving the information. COMPANY shall provide GI within
[**] after receiving GI's written notice with the necessary information. GI will
oblige Europe-RNAi accordingly.

Within [**] after GI's receipt of the necessary information from COMPANY and
Europe-RNAi, GI and COMPANY shall mutually agree, jointly with EuropeRNAi, [**]
according to the estimated market size and accessibility by RNAi within the
FIELD between COMPANY and Europe-RNAi. After such split, the indications and
sub-indications awarded to COMPANY shall be regarded as exclusively licensed to
COMPANY.

If the parties do not agree within the timeframe, each party has the right to
initiate arbitration procedure according to Section 12.3.

In the event that, within [**] years after the EFFECTIVE DATE, (i) COMPANY or
EuropeRNAi merges with a third party in a transaction in which the shareholders
of COMPANY or EuropeRNAi (who hold shares in COMPANY or EuropeRNAi immediately
before such merger) own less than [**]% ([**] percent) of the shares of the
resulting entity after such merger, or (ii) a third party acquires all or
substantially all of the assets or shares of COMPANY or EuropeRNAi, this Section
2.3 shall not apply.

2.4      Sublicenses

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Within [**] years after the EFFECTIVE DATE, COMPANY is not allowed to grant
sublicenses to third parties without the prior approval of GI, which shall not
unreasonably be withheld. COMPANY shall inform GI in writing in due time prior
to the intended signature, of any sublicense agreement in sufficient detail to
permit GI to decide whether or not to approve. GI shall inform COMPANY in
writing within [**] days after receiving the information whether or not GI
approves; in particular, GI may withhold its approval if GI deems the reveived
information not sufficient. Notwithstanding the foregoing, COMPANY may grant,
within [**] years after the EFFECTIVE DATE, [**] for a specific indication to a
third party without the prior approval of GI, in which event COMPANY is obliged
to reserve an indication of comparable market size and RNAi accessibility to the
indication covered by the sublicense for EuropeRNAi.

After [**] years after the EFFECTIVE DATE, COMPANY is allowed to grant
sublicenses to third parties without the prior approval of GI.

Immediately after the signature of each sublicense granted under this Agreement,
COMPANY shall provide GI with a copy of the signed sublicense agreement, and
COMPANY shall confirm in writing to GI that COMPANY shall be liable for payment
of royalties on NET SALES of the SUBLICENSEE in accordance with Sections 5.2 and
5.3.

2.5      Retained Rights

OWNERS retain the right to practice under the PATENT RIGHTS for research,
teaching, education, non-commercial collaboration and publication purposes.
COMPANY acknowledges that the German and the U.S. federal government retain a
royalty-free, non-exclusive, non-transferable license to practice any
government-funded invention claimed in any PATENT RIGHTS for government
purposes.

2.6      No Additional Rights

Nothing in this Agreement shall be construed to confer any rights upon COMPANY
by implication, estoppel, or otherwise as to any intellectual property rights,
including without limitation patents and patent applications, trademarks,
copyrights and know-how, of the OWNERS other than the PATENT RIGHTS, regardless
of whether such intellectual property rights shall be dominant or subordinate to
any PATENT RIGHTS.

ARTICLE 3 - NO REPRESENTATIONS OR WARRANTIES

COMPANY is informed of the PATENT RIGHTS and the difficult patent situation in
the field of RNAi, and that it might need additional licenses from third parties
to have freedom to operate. GI and THE OWNERS MAKE NO REPRESENTATIONS OR
WARRANTIES OF ANY KIND CONCERNING THE PATENT RIGHTS, EXPRESS OR IMPLIED, AND THE
ABSENCE OF ANY LEGAL OR ACTUAL DEFECTS, WHETHER OR NOT DISCOVERABLE.
Specifically, and not to limit the foregoing, GI and the OWNERS make no warranty
or representation (i) regarding the merchantability or fitness for a particular
purpose of the PATENT RIGHTS, (ii) regarding the patentability, validity or
scope of the PATENT RIGHTS, (iii) that the exploitation of the PATENT

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RIGHTS or any LICENSED PRODUCT will not infringe any patents or other
intellectual property rights of the OWNERS or of a third party, and (iv) that
the exploitation of the PATENT RIGHTS or any LICENSED PRODUCT will not cause any
damages of any kind to COMPANY or a third party.

IN NO EVENT SHALL GI, THE OWNERS, THEIR TRUSTEES, DIRECTORS, OFFICERS, EMPLOYEES
AND AFFILIATES BE LIABLE FOR INCIDENTAL OR CONSEQUENTIAL DAMAGES OF ANY KIND,
INCLUDING ECONOMIC DAMAGES OR INJURY TO PROPERTY AND LOST PROFITS, REGARDLESS OF
WHETHER GI OR ANY OF THE OWNERS SHALL BE ADVISED, SHALL HAVE OTHER REASON TO
KNOW, OR IN FACT SHALL KNOW OF THE POSSIBILITY OF THE FOREGOING.

ARTICLE 4 - COMPANY DILIGENCE OBLIGATIONS AND REPORTS

4.1      Activity Requirements

COMPANY shall use commercially reasonable efforts, and shall oblige its
SUBLICENSEES to use commercially reasonable efforts, to develop and to introduce
into the commercial market LICENSED PRODUCTS at the earliest practical date.

4.2      Development Reports

Commencing with the beginning of 2003, COMPANY shall furnish, and shall oblige
its SUBLICENSEES to furnish to COMPANY for inclusion in its reports to GI, to GI
in writing, within 30 (thirty) days after the end of each calendar quarter with
COMPANY's standard R&D report, as provided to the investors pursuant to the
Amended and Restated Investor's Rights Agreement Series B, on the progress of
its efforts during the immediately preceding calendar quarter to develop and
commercialize LICENSED PRODUCTS for each indication and sub-indication within
the FIELD. The report shall also contain a discussion of intended R&D efforts
for the calendar quarter in which the report is submitted.

4.3      Target Specific Sublicenses

[**] years after the EFFECTIVE DATE, COMPANY shall be obliged to enter into good
faith negotiations on reasonable terms and conditions with a third party
requesting a sublicense under the PATENT RIGHTS for the development, use and
sale of products against a target gene in a specific indication or
sub-indication which is covered by pending or issued patent rights of such third
party, provided, however, that

(a)      COMPANY has not entered into a sublicense or is in serious negotiations
         for a sublicense for the use of [**], or

(b)      COMPANY can not demonstrate, through its standard research planning
         documents, significant current work which has commenced or is scheduled
         to commence within [**], to develop, within reasonable time, [**].

COMPANY shall inform GI on a quarterly basis of all such third party sublicense
requests, and

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whether or not COMPANY has granted such sublicense. In the event of non-grant,
COMPANY shall, upon GI's request, provide GI, within [**] after receiving GI's
request, with information in sufficient detail showing COMPANY's reason for the
non-grant.

If GI decides that COMPANY did not fulfill the requirements of (a) or (b),
and/or that COMPANY's terms and conditions for the requested sublicense have
been unreasonable, GI may initiate the arbitration procedure according to
Section 12.3. If the award of the arbitration tribunal states a non-fulfillment
of the requirements of (a) or (b), COMPANY shall immediately start negotiations
with the third party; if the award of the arbitration tribunal states
unreasonable terms and conditions, COMPANY shall immediately re-negotiate
reasonable terms and conditions with the third party. In any such awards of the
arbitration tribunal, the costs for the arbitration procedure shall be borne
solely by COMPANY.

4.4      Liability for SUBLICENSEES

If SUBLICENSEES of COMPANY develop, manufacture, use and/or sell LICENSED
PRODUCTS under the PATENT RIGHTS, COMPANY warrants and is liable towards GI that
the SUBLICENSEES perform their sublicense agreement in accordance with this
Agreement, and COMPANY shall be responsible and liable for royalty payments and
reports of the SUBLICENSEES.

4.5      Effect of Failure

In the event that GI determines that COMPANY or any of its SUBLICENSEES has
failed to fulfill any of its obligations under this Section 4, then GI may treat
such failure as a material breach in accordance with Section 11.7.

ARTICLE 5 - SHARES, ROYALTIES AND PAYMENT TERMS

5.1      Shares

As partial consideration for the grant of rights, COMPANY shall transfer to the
OWNERS cost-free 6% (six percent), or a proportionally reduced percentage
according to Appendix D 1, of COMPANY's total capital stock, which is currently
(post Series B) 12,200,010 shares. This translates currently, in the event of a
6% transfer, into 732,000 (seven hundred thirty two thousand) existing shares or
778,724 (seven hundred seventy eight thousand seven hundred twenty four) newly
issued shares. The transfer of shares according to this Section 5.1 to the
OWNERS shall be effected by COMPANY on or before March 31, 2003; such shares
shall be transferred irrevocably and non-retransferably, and shall be registered
as preferred shares Series B. In the event of an increase of COMPANY's total
number of shares prior to the transfer to the OWNERS, the number of shares to be
transferred to the OWNERS shall be increased to six percent of the increased
total capital stock.

In the event that COMPANY fulfills the REQUIREMENTS of Appendix C 1 and C 2, and
all of the OWNERS approve the Plan, then GI and the OWNERS shall grant a second
co-exclusive license to EuropeRNAi substantially identical to this Agreement. In
the event that COMPANY

                                                      Alnylam; GI 2716, 2782 ZTM
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fulfills the REQUIREMENTS of Appendix C 1, and any of the OWNERS does not
approve the Plan, then Appendix D 2c) shall apply. In the event that COMPANY
fulfills the REQUIREMENTS of Appendix C 1 and C2, and any of the OWNERS does not
grant the second co-exclusive license to EuropeRNAi, then Appendix D 2c) shall
apply.

5.2      Running Royalties

COMPANY shall pay to GI the following running royalties on NET SALES of
therapeutic and prophylactic LICENSED PRODUCTS by COMPANY and its SUBLICENSEES:

(a)      [**]% (one point five percent) of the first US$[**] ([**] US Dollars)
         of annual accumulated NET SALES of all LICENSED PRODUCTS ;

(b)      [**]% (one point seven percent) of annual accumulated NET SALES of all
         LICENSED PRODUCTS between US$[**] ([**] US Dollars) and US$[**] ([**]
         US Dollars);

(c)      [**]% ([**] percent) of annual accumulated NET SALES of all LICENSED
         PRODUCTS between US$[**] ([**] US Dollars) and US$[**] ([**] US
         Dollars);

(d)      [**]% [**] percent) of annual accumulated NET SALES of all LICENSED
         PRODUCTS between US$[**] ([**] US Dollars) and US$[**] ([**] US
         Dollars);

(e)      [**]% ([**] percent) of annual accumulated NET SALES of all LICENSED
         PRODUCTS between US$[**] ([**] US Dollars) and US$[**] ([**] US
         Dollars); and

(f)      [**]% ([**] percent) of annual accumulated NET SALES of all LICENSED
         PRODUCTS above US$[**] ([**] US Dollars).

In the event that COMPANY or a SUBLICENSEE develops diagnostic LICENSED
PRODUCTS, COMPANY shall initiate negotiations with GI at least [**] prior to the
intended first commercial sale of each diagnostic LICENSED PRODUCT. COMPANY and
GI shall negotiate in good faith [**] for such diagnostic LICENSED PRODUCT.

If the sale of any LICENSED PRODUCT is covered by more than one of the PATENT
RIGHTS, multiple royalties shall not be due.

Non-cash consideration shall not be accepted by COMPANY or any SUBLICENSEE for
LICENSED PRODUCTS without the prior written consent of GI.

5.3      Royalty Stacking

(a)      Third Party Licenses

In the event COMPANY or a SUBLICENSEE takes, for objective commercial and/or
legal reasons, a license from any third party under any patent applications or
patents that dominate the PATENT RIGHTS or is dominated by the PATENT RIGHTS in
order to develop, make, use, sell or import any LICENSED PRODUCT (explicitly
excluding, without limitation, any third party patents and patent applications
for formulation, stabilization and delivery), then COMPANY is allowed to deduct
[**]% ([**] percent) of any additional running royalties to be paid to such
third party up to [**]% ([**] percent) of the running royalties stated in
Section 5.2, from the date COMPANY has to pay running royalties to such third
party. However, the running royalties stated in Section 5.2 shall not be reduced
to less than a minimum of [**]% ([**] percent) of NET SALES in any case.

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For avoidance of doubt, if COMPANY or a SUBLICENSEE takes a license to a third
party target, COMPANY is in no event allowed to deduct any license fees for such
target from running royalties due to GI under this Agreement.

(b)      PATENT RIGHTS Coverage

In the event that (i) COMPANY or its SUBLICENSEES sell a LICENSED PRODUCT in a
country where no PATENT RIGHTS are issued and no patent applications that are
part of the PATENT RIGHTS are pending that have not been pending for less than
[**] years after filing national patent applications in the country in question,
and (ii) such LICENSED PRODUCT is manufactured in a country where PATENT RIGHTS
are issued or patent applications that are part of the PATENT RIGHTS are pending
that have not been pending for more than [**] years after filing national patent
applications in the country in question, the royalties stated in Section 5.2
will be reduced by [**]% ([**] percent) for such LICENSED PRODUCT, until the
expiration or abandonment of all issued patents and filed patent applications
within the PATENT RIGHTS in the country in which the LICENSED PRODUCT is
manufactured.

5.4      Reports

Within 30 (thirty) days of the end of each calendar half year, COMPANY shall
deliver a detailed report to GI for the immediately preceding calendar half year
showing at least (i) the number of LICENSED PRODUCTS sold by COMPANY and its
SUBLICENSEES in each country, (ii) the gross price charged by COMPANY and its
SUBLICENSEES for each LICENSED PRODUCTS in each country, (iii) the calculation
of NET SALES, and (iv) the resulting running royalties due to GI according to
those figures. If no running royalties are due to GI, the report shall so state.

5.5      Payments

(a)      Accounting and Payments

Running royalties shall be payable for each calendar half year, and shall be due
to GI within 60 (sixty) days of the end of each calendar half year.

(b)      Method of Payment

All payments under this Agreement shall be made payable to "Garching Innovation
GmbH" to the following account: Bayerische Hypo- und Vereinsbank AG; account
number [**]; bank code 700 202 70; SWIFT address: HYVEDEMMXXX. Each payment
shall reference this Agreement and the obligation under this Agreement that the
payment satisfies.

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(c)      Payments in US Dollars

All payments due under this Agreement shall be payable in US Dollars and, if
legally required, shall be paid with the additional value added tax. Conversion
of foreign currency to US Dollars shall be made at the conversion rate existing
in the United States (as reported in the Wall Street Journal) on the last
working day of the relevant calendar half year. Such payments shall be without
deduction of exchange, collection, or other charges, except for deduction of
withholding or similar taxes.

(d)      Late Payments

Any payments by COMPANY that are not paid on or before the date such payments
are due under this Agreement shall bear interest on arrears at 2 % (two
percentage points) above the Prime Rate of interest as reported in the Wall
Street Journal on the date the payment is due.

5.6      Bookkeeping and Auditing

COMPANY is obliged to keep, and shall oblige its SUBLICENSEES to keep, complete
and accurate books on any reports and payments due to GI under this Agreement,
which books shall contain sufficient information to permit GI to confirm the
accuracy of any reports and payments made to GI. GI, or GI's appointed agents,
is authorized to check the books of COMPANY, and, upon GI's request, COMPANY, or
agents appointed by GI for COMPANY, shall check the books of its SUBLICENSEES
for GI, once a year. The charges for such a check shall be borne by GI. In the
event that such check reveals an underpayment in excess of 5% (five percent),
COMPANY shall bear the full cost of such check and shall remit any amounts due
to GI within thirty days of receiving notice thereof from GI.

The right of auditing by GI under this Section shall expire five years after
each report or payment has been made. Sublicenses granted by COMPANY shall
provide that COMPANY shall have the right to check the books of its SUBLICENSEES
according to this Section 5.6.

5.7      No Refund

All payments made by COMPANY or its SUBLICENSEES under this Agreement are
nonrefundable and noncreditable against each other.

ARTICLE 6 - PATENT PROSECUTION AND INFRINGEMENT

6.1      Responsibility for PATENT RIGHTS

The OWNERS shall, in their sole discretion, apply for, seek issuance of,
maintain, or abandon the PATENT RIGHTS during the TERM of this Agreement. GI
shall (i) keep COMPANY reasonably informed as to the filing, prosecution,
maintenance and abandonment of the PATENT RIGHTS, (ii) furnish COMPANY copies of
documents relevant to any such filing, prosecution maintenance and abandonment,
and (iii) allow COMPANY reasonable opportunity to comment and advise on patent
attorneys to be used and on documents to be filed with any patent office which
would affect the PATENT RIGHTS in the FIELD, and (iv) give good faith

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consideration to the comments and advice of COMPANY.

In the event that all OWNERS wish to cease prosecution or abandon any of the
PATENT RIGHTS, GI shall notify COMPANY thereof in writing in due time, and shall
offer COMPANY the right to continue prosecution or maintenance of such PATENT
RIGHTS in its discretion, in its name and at its expense. GI will inform and
offer EuropeRNAi respectively. If COMPANY does not accept GI's offer within 30
(thirty) days after receiving it, the OWNERS shall be free to cease prosecution
or abandon such PATENT RIGHTS. In any event, if the manufacture and sale of a
LICENSED PRODUCT is solely covered by such PATENT RIGHTS, the respective NET
SALES are not royalty-bearing.

6.2      Patent Costs

COMPANY shall pay to GI [**]% ([**] percent) of all fees and costs, including
attorneys fees, relating to the filing, prosecution and maintenance of the
PATENT RIGHTS, which incur during the TERM. GI shall decide, in its sole
discretion, if such costs shall be paid directly by COMPANY to the creditor, or
if COMPANY shall reimburse GI for all amounts due pursuant to this Section
within 30 (thirty) days of invoicing.

In addition, if any or all of the current and future licensees which bear patent
costs cease to pay, for whatever reason, their respective patent cost share,
then COMPANY shall assume [**]% ([**]percent) of such share. GI will oblige
EuropeRNAi respectively.

Furthermore, if COMPANY wishes to prosecute or maintain any of the PATENT RIGHTS
in countries where none of the current and future licensees want to prosecute or
maintain, COMPANY shall bear [**]% ([**] percent) of all fees and costs relating
to such PATENT RIGHTS.

In the event that COMPANY wishes to cease payment for any of the PATENT RIGHTS,
COMPANY shall notify GI thereof in writing in due time, at least 3 months prior
to any deadline. The OWNERS shall have the right to continue payment for such
PATENT RIGHTS in their discretion and at their expense. In any event, such
PATENT RIGHTS shall no longer be covered by this Agreement from the date COMPANY
informs GI of its cessation of payments.

6.3      Infringement

COMPANY shall inform GI promptly in writing of any alleged infringement of the
PATENT RIGHTS by a third party and of any available evidence thereof.

Subject to COMPANY's right to join in the prosecution of infringements set forth
below, the OWNERS shall have the right, but not the obligation, to prosecute in
their own discretion and at their own expense, all infringements of the PATENT
RIGHTS. The total cost of any such sole infringement action shall be borne by
the OWNERS, and the OWNERS shall keep any recovery or damages derived therefrom.
In any such infringement suits, COMPANY shall, at the OWNERS' expense, cooperate
in all respects.

COMPANY shall have the right to join the OWNERS' prosecution of any
infringements of the PATENT RIGHTS: In any such joint infringement suits, the
OWNERS and COMPANY will cooperate in all respects. The OWNERS and COMPANY will
agree in good faith on the sharing of the total cost of any such joint
infringement action and the sharing of any recovery or

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 13

<PAGE>

damages derived therefrom.

In the event that the OWNERS decide not to prosecute infringements of the PATENT
RIGHTS, neither solely nor jointly with COMPANY, GI shall offer to COMPANY to
prosecute any such infringement in its own discretion and at its own expense. GI
will offer EuropeRNAi respectively. The OWNERS shall, at COMPANY'S expense,
cooperate. The total cost of any such sole infringement action shall be borne by
COMPANY, and COMPANY shall keep any recovery or damages derived therefrom.

In the event that COMPANY intends to make any arrangements with the infringer to
settle the infringement (such as sublicenses), and solely the OWNERS or the
OWNERS jointly with COMPANY have prosecuted the infringement, any such
settlement needs the prior written approval of GI, which shall not unreasonably
be withheld; reasons to withheld include, without limitation, that the
settlement is financially disadvantageous for the OWNERS or GI. Any infringer to
which COMPANY grants such sublicenses shall be a SUBLICENSEE under this
Agreement.

ARTICLE 7 - INDEMNIFICATION AND INSURANCE

7.1      Indemnification

COMPANY shall indemnify, defend, and hold harmless the OWNERS and their
trustees, officers, faculty, students, employees, and agents and their
respective successors, heirs and assigns (the "Indemnitees"), against any
liability, damage, loss, or expense (including reasonable attorneys fees and
expenses) incurred by or imposed upon any of the Indemnitees in connection with
any claims, suits, actions, demands or judgments arising out of any theory of
liability (including without limitation actions in the form of tort, warranty,
or strict liability and regardless of whether such action has any factual basis)
concerning (i) any use of the PATENT RIGHTS by COMPANY or its SUBLICENSEES, or
(ii) any product, process, or service that is developed, made, used, sold, or
performed pursuant to any right or license granted under this Agreement.

7.2      Insurance

COMPANY shall obtain and carry in full force and effect commercial general
liability insurance, including product liability and errors and omissions
insurance, which shall protect COMPANY and the Indemnitees with respect to
events covered by Section 7.1 above. Such insurance shall list GI and the OWNERS
as additional insured, and the limit of insurance shall not be less than
1,000,000 $ (one million US Dollars) per incident. Upon request, COMPANY shall
provide GI with certificates of insurance evidencing compliance with this
section.

ARTICLE 8 - CONFIDENTIALITY

8.1      Obligation for Company

The content of this Agreement and any information marked confidential which is
disclosed to COMPANY under this Agreement by GI or the OWNERS shall be treated
confidential by

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 14

<PAGE>

COMPANY during the TERM and for 5 (five) years thereafter. COMPANY shall not use
such information for any purposes other than those necessary to directly further
the purpose of this Agreement. COMPANY may disclose such information to its
actual and prospective SUBLICENSEES, investors, lenders, other financing
sources, acquirors and third parties being acquired by COMPANY, provided
however, that COMPANY has entered into serious discussions with such entities,
and such entities have requested such information, and such entities are obliged
to confidentiality to the same extent as COMPANY.

The confidentiality obligation shall not apply to information which is (i)
publicly available or becomes publicly available through no fault of COMPANY, or
(ii) obtained by COMPANY from another source without a duty of confidentiality,
or (iii) demonstrably independently developed or possessed by COMPANY, or (iv)
is required by law, regulation, accounting principles or an order of a court or
government agency to be disclosed.

8.2      Obligation for GI

The content of this Agreement and any information marked confidential which is
disclosed to GI under this Agreement by COMPANY or its SUBLICENSEES shall be
treated confidential by GI during the TERM and for 5 (five) years thereafter. GI
shall not use such information for any purposes other than those necessary to
directly further the purpose of this Agreement. GI may disclose such information
to the OWNERS, provided however, that the OWNERS are obliged to confidentiality
to the same extent as GI.

The confidentiality obligation shall not apply to information which is (i)
publicly available or becomes publicly available through no fault of GI, or (ii)
obtained by GI from another source without a duty of confidentiality, or (iii)
demonstrably independently developed or possessed by GI, or (iv) is required by
law, regulation, accounting principles or an order of a court or government
agency to be disclosed.

ARTICLE 9 - NO ASSIGNMENT OR TRANSFER

9.1      Assignment

This Agreement is personal to COMPANY and no rights or obligations may be
assigned by COMPANY to a third party or a SUBLICENSEE or EuropeRNAi without the
prior written consent of GI, except that sublicenses may be granted in
accordance with Section 2.4, and except that COMPANY may assign its rights and
obligations under this Agreement to a successor in connection with the merger,
consolidation, or sale of all or substantially all of its assets or that portion
of its business to which this Agreement relates; provided, however, that this
Agreement shall immediately terminate if the proposed assignee fails to agree in
writing to be bound by the terms and conditions of this Agreement on or before
the effective date of the assignment. After the effective date of the
assignment, the assignee shall provide GI, upon GI's request, with written
reports in reasonable detail on the actual and intended future activities of the
assignee to develop and commercialise LICENSED PRODUCTS. If the reports are not
provided to GI in due time and/or in sufficient detail, such failure will be a
material breach under Section 11.7, and GI

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 15

<PAGE>

shall have the right to terminate this Agreement in accordance with the
procedures set forth in Section 11.7.

9.2      Transfer to Europe-RNAi

Notwithstanding Section 9.1, the assignment or transfer of this Agreement in
whole from COMPANY to Europe-RNAi as new licensee, for example in connection
with a sale or transfer of at least 50% of COMPANY's assets or that portion of
its business to which this Agreement relates, needs the prior written consent of
GI, if such sale or transfer is implemented within 5 (five) years after the
EFFECTIVE DATE, unless such sale or transfer is in connection with an Initial
Public Offering or a trade sale whereby a third party acquires both COMPANY and
EuropeRNAi.

COMPANY shall inform GI immediately of any intended such sale or transfer.

ARTICLE 10 - GENERAL COMPLIANCE WITH LAWS

10.1     Compliance with Laws

COMPANY shall use commercially reasonable efforts to comply with all local,
state, federal, and international laws and regulations relating to the
development, manufacture, use and sale of LICENSED PRODUCTS.

10.2     Non-Use of OWNERS Names

Neither COMPANY nor its SUBLICENSEES shall use the name of "Massachusetts
Institute of Technology," "University of Massachusetts", "Whitehead Institute",
"Max Planck Institute", "Max Planck Society", "Garching Innovation" or any
variation, adaptation, or abbreviation thereof, or of any of its trustees,
officers, faculty, students, employees, or agents, or any trademark owned by any
of the OWNERS, in any promotional material or other public announcement or
disclosure without the prior written consent of the OWNERS or in the case of an
individual, the consent of that individual. The foregoing notwithstanding,
without the consent of the OWNERS, COMPANY may state generally that it is
co-exclusively licensed by the OWNERS under the PATENT RIGHTS.

ARTICLE 11 - EFFECTIVENESS AND TERMINATION

11.1     Effectiveness

The effectiveness of this Agreement is subject to the approval of all OWNERS.

In the event that all OWNERS approve on or before Jan. 31, 2003, this Agreement
shall become effective retroactively on the EFFECTIVE DATE.

In the event that not all OWNERS approve on or before Jan. 31, 2003, this
Agreement shall be amended in writing according to Appendix D 1.

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 16

<PAGE>

11.2     Voluntary Termination by COMPANY

COMPANY shall have the right to terminate this Agreement, for any reason, (i)
upon at least 6 (six) months prior written notice to GI, such notice to state
the date at least 6 (six) months in the future upon which termination is to be
effective, and (ii) upon payment of all amounts due to GI through such
termination effective date.

11.3     Cessation of Business

If COMPANY ceases to carry on its business related to this Agreement, COMPANY
has to inform GI thereof immediately. COMPANY and GI shall have the right to
terminate this Agreement immediately upon written notice to the other.

11.4     Change of Ownership

In the event that at least 50% (fifty percent) of COMPANY'S stock capital is
assigned or transferred to a third party or a SUBLICENSEE, COMPANY shall provide
GI, upon GI's request, with written reports in reasonable detail on the actual
and intended future activities of COMPANY to develop and commercialise LICENSED
PRODUCTS. If the reports are not provided to GI in due time and/or in sufficient
detail, such failure will be a material breach under Section 11.7, and GI shall
have the right to terminate this Agreement in accordance with the procedures set
forth in Section 11.7.

GI shall have the right to terminate this Agreement immediately upon written
notice to COMPANY, if at least 50% (fifty percent) of COMPANY'S stock capital is
assigned or transferred to EuropeRNAi within 5 (five) years after the EFFECTIVE
DATE, except in connection with an Initial Public Offering or a trade sale
whereby a third party acquires both COMPANY and EuropeRNAi.

COMPANY shall inform GI immediately of the implementation of any such assignment
or transfer.

11.5     Attack on PATENT RIGHTS

GI shall have the right to terminate this Agreement immediately upon written
notice to COMPANY, if COMPANY attacks, or has attacked or supports an attack
through a third party, the validity of any of the PATENT RIGHTS. To the extent
legally enforcable, sublicenses granted by COMPANY shall provide that in the
event the SUBLICENSEE attacks, or has attacked or supports an attack through a
third party, the validity of any of the PATENT RIGHTS, COMPANY shall have the
right to terminate the sublicense agreement immediately; upon request of GI,
COMPANY shall have the obligation to terminate such sublicense agreement.

11.6     Licenses to EuropeRNAi

In the event that

(i) COMPANY does not grant to EuropeRNAi a worldwide non-exclusive unrestricted
royalty-free license, with the right to grant sublicenses, to all of COMPANY'S
existing and future intellectual property rights owned or controlled by COMPANY,
including without limitation patents and patent applications, trademarks,
copyrights and know-how, necessary or useful to perform

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 17

<PAGE>

EuropeRNAi's business in the field of RNAi, or

(ii) COMPANY does not grant to EuropeRNAi a worldwide non-exclusive
unrestricted, with royalties payable only with respect to COMPANY's royalty
obligations towards its licensor, sublicense, with the right to grant further
sublicenses to the greatest extent permitted by its licensor, to all
intellectual property rights currently and in the future licensed to COMPANY,
including without limitation patents and patent applications, trademarks,
copyrights and know-how, necessary or useful to perform EuropeRNAi's business in
the field of RNAi,

GI shall have the right to terminate this Agreement immediately upon written
notice to COMPANY, if COMPANY fails to grant such licenses or sublicenses to
EuropeRNAi within 30 (thirty) days after receiving written notice thereof from
GI.

This Section 11.6 shall not apply in the event that (i) COMPANY or EuropeRNAi
merges with a third party in a transaction in which the shareholders of COMPANY
or EuropeRNAi (who hold shares in COMPANY or EuropeRNAi immediately before such
merger) own less than 50% (fifty percent) of the shares of the resulting entity
after such merger, or (ii) a third party acquires all or substantially all of
the assets or shares of COMPANY or EuropeRNAi.

11.7     Termination for Default

In the event COMPANY fails to pay any amounts due and payable to GI hereunder,
and fails to make such payments within 30 (thirty) days after receiving written
notice of such failure, GI may terminate this Agreement immediately upon written
notice to COMPANY. Notwithstanding the foregoing, in the event COMPANY commits a
material breach of its obligations under this Agreement, and fails to cure that
breach within 60 (sixty) days after receiving written notice thereof, GI may
terminate this Agreement immediately upon written notice to COMPANY.

Notwithstanding the foregoing, if COMPANY disputes any alleged failure to make a
payment or alleged material breach, the matter shall be resolved in accordance
with Section 12.3, and if the matter is resolved against COMPANY, COMPANY shall
have 10 (ten) days from the final decision of the arbitration tribunal to make
the payment, with additional interest on arrears according to Section 5.5 (d),
or cure the breach.

11.8     Effect of Termination

The following provisions shall survive the expiration or termination of this
Agreement: Articles 1, 3, 5.5, 7, 8, 12 and Section 11.1 and 11.8. In no event
shall termination of this Agreement release COMPANY or its SUBLICENSEES from the
obligation to pay any amounts that became due on or before the effective date of
termination.

In the event that any license granted to COMPANY under this Agreement is
terminated, any sublicense under such license granted prior to termination of
said license shall remain in full fore and effect, provided that:

(a) the SUBLICENSEE is not then in breach of its sublicense agreement, and

(b) the SUBLICENSEE agrees to be bound to GI as licensor under the terms and
conditions of the sublicense agreement, provided that GI shall have no other
obligation than to leave the sublicense granted by COMPANY in place.

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 18

<PAGE>

11.9     Insolvency

This Agreement shall terminate automatically, if (i) COMPANY files a petition in
bankruptcy, or (ii) COMPANY makes an assignment for the benefit of creditors, or
(iii) a petition in bankruptcy is filed against COMPANY and not dismissed within
90 (ninety) days.

ARTICLE 12 - MISCELLANEOUS

12.1     Notice

Any notices required or permitted under this Agreement and all correspondence
hereunder shall be in English and in writing, shall specifically refer to this
Agreement, and shall be sent by a method providing confirmation of delivery to
the following addresses or facsimile numbers of the parties:

If to GI:         Garching Innovation GmbH
                  Hofgartenstrasse 8
                  D-80539 Muenchen/Germany
                  Tel: +49/89/290919-0
                  Fax: +49/89/290919-99

If to COMPANY:    Alnylam Pharmaceuticals Inc.
                  790 Memorial Drive, Suite 202,
                  Cambridge, MA 02139, USA
                  Tel: +1-617-252-0700
                  Fax: +1-617-252-0011

All notices under this Agreement shall be deemed effective upon receipt. A party
may change its contact information immediately upon written notice to the other
party in the manner provided in this Section.

12.2     Governing Law

The parties explicitly agree and deem appropriate that this Agreement and all
disputes arising out of or related to this Agreement, or the performance,
enforcement, breach or termination hereof, and any remedies relating thereto,
shall be construed, governed, interpreted and applied in accordance with the
laws of the Federal Republic of Germany, except that questions affecting the
construction and effect of any patent shall be determined by the law of the
country in which the patent shall have been granted.

12.3     Dispute Resolution

The parties shall attempt to settle any dispute or claim arising out of or
relating to this Agreement by good faith negotiations. If the parties fail to
agree on a reasonable settlement within 60 (sixty) days after the affected party
informed the other party in writing of such dispute or claim, either

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 19

<PAGE>

party may initiate arbitration under the procedural Rules of the International
Chamber of Commerce upon written notice to the other party within 30 (thirty)
days after such failure. The arbitration tribunal shall be appointed as follows:
each party shall select, within 30 (thirty) days after notice to initiate
arbitration, an independent and experienced third party as its arbitrator. The
two arbitrators selected by the parties shall mutually select an independent and
experienced third party as third arbitrator. The venue for the arbitration
procedure shall be London, England, the language shall be English, and German
law shall be applied. The award of the arbitration tribunal shall be final and
binding for the parties. Notwithstanding the foregoing, each party may apply for
interlocutory relief in court.

12.4     Amendment and Waiver

This Agreement may be amended, supplemented, or otherwise modified only by means
of a written instrument signed by both parties. Any waiver of any rights or
failure to act in a specific instance shall relate only to such instance and
shall not be construed as an agreement to waive any rights or fail to act in any
other instance, whether or not similar.

12.5     Severability

Should one of the provisions of this Agreement be held void, invalid or
unenforceable, the remaining provisions of this Agreement will not cease to be
effective. The parties shall negotiate in good faith to replace such void,
invalid or unenforceable provision by a new provision which reflects, to the
extent possible, the original intent of the parties.

12.6     Headings

All headings are for convenience only and shall not affect the meaning of any
provision of this Agreement.

IN WITNESS WHEREOF, the parties have caused this Agreement to be executed by
their duly authorized representatives.

Garching Innovation GmbH                          Alnylam, Inc.

By:    /s/Bernhard Hertel                         By:    /s/John Maraganore
       --------------------------                        -----------------------
Name:  Dr. Bernhard Hertel                        Name:  John Maraganore
Title: Managing Director                          Title: Chief Executive Officer
Date:  12/20/02                                   Date:  12/20/02
       --------------------------                        -----------------------

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 20

<PAGE>

                                   APPENDIX A

                               JOINT PATENT RIGHTS

I.       United States Patents and Applications

USSN [**] entitled [**]

USSN [**] entitled [**]

II.      International (non-U.S.) Patents and Applications

[**] entitled [**]

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 21

<PAGE>

                                   APPENDIX B

                            MAX-PLANCK PATENT RIGHTS

I.       United States Patents and Applications
USSN [**] entitled [**]

II.      International (non-U.S.) Patents and Applications

European Serial Number [**] entitled [**]

[**] entitled "[**]

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 22

<PAGE>

                                   APPENDIX C

                                  REQUIREMENTS

1. within three months after the EFFECTIVE DATE:

COMPANY shall provide GI and the OWNERS with the final plan for structuring
EuropeRNAi for approval (the "Plan") the Plan shall address and solve, without
limitation, the following issues:

a)       legal and institutional policy needs of each of the OWNERS

b)       initial and future identical percentage shareholding of the
         shareholders of COMPANY in EuropeRNAi;

c)       initial financing of EuropeRNAi, and future financing of both
         EuropeRNAi and COMPANY;

d)       EuropeRNAi must have a German AG or GmbH with comparable operational
         forces in terms of budget, employees, R&D and BD capacity as COMPANY;

e)       problems and solutions of M&A transactions of only COMPANY or
         EuropeRNAi with a third party, if the third party acquires or is
         acquired by COMPANY or EuropeRNAi; security of fulfillment of
         REQUIREMENTS and access to intellectual property in such a scenario;

f)       mechanism how both COMPANY and EuropeRNAi can give each other full
         access to all current and future intellectual property which is useful
         or needed to perform the business in each ones indication fields;

g)       restructuring options of both COMPANY and EuropeRNAi in case of an IPO
         or trade sale.

2. within one month after Plan approval by one or more of the OWNERS:

incorporation of EuropeRNAi and the German AG/GmbH according to the Plan effect
of non-approval of the Plan by one or more OWNERS on the EuropeRNAi-license: see
Appendix D 2.

3. within three months after Plan approval

OWNERS shall receive cost-free 6% (six percent) of EuropeRNAi's total stock
capital; effect of non-approval of the Plan by one or more OWNERS on the shares:
see Appendix D 2. the transferred shares shall be registered equivalent to the
preferred shares issued to the investors (who hold preferred shares Series B in
COMPANY) in EuropeRNAi and shall be irrevocable and non-retransferable.

4. within eight months after Plan approval:

in place: laboratory and office in Germany with a minimum of six full time
employees

5. after eight months after Plan approval and until two years after the
EFFECTIVE DATE: EuropeRNAi and COMPANY shall use reasonable commercial efforts
to build for EuropeRNAi capabilities to develop, make, use, sell or import
LICENSED PRODUCTS comparable to COMPANY

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 23

<PAGE>

6. after Plan approval and for five years after the EFFECTIVE DATE:

no direct or indirect shareholding of COMPANY in EuropeRNAi without the OWNERS's
approval, except in connection with an Initial Public Offering or a trade sale
whereby a third party acquires both COMPANY and EuropeRNAi

7. for as long as (i) COMPANY or EuropeRNAi does not merge with a third party in
a transaction in which the shareholders of COMPANY or EuropeRNAi (who hold
shares in COMPANY or EuropeRNAi immediately before such merger) own less than
50% (fifty percent) of the shares of the resulting entity after such merger, or
(ii) a third party does not acquire all or substantially all of the assets or
shares of COMPANY or EuropeRNAi:

both COMPANY and EuropeRNAi shall give each other full access to all current and
future intellectual property which is useful or needed to perform the business
in each ones indication fields, excluding the intellectual property licensed
under this Agreement.

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 24

<PAGE>

                                   APPENDIX D

                             EFFECT OF NON-APPROVAL

1. In the event that one or more of the OWNERS do not approve this Agreement on
or before Jan. 31, 2003,

a)       the non-approving OWNERS shall be excluded from this Agreement, in
         particular their ownership position in the PATENT RIGHTS shall be
         excluded from the PATENT RIGHTS;

b)       the non-approving OWNERS do not receive any shares from COMPANY; the
         shares stated in Section 5.1 shall be reduced according to the
         proportional internal ownership of the non-approving OWNERS in the
         PATENT RIGHTS, and COMPANY shall transfer the so determined reduced
         number of shares to the approving OWNERS;

c)       the non-approving OWNERS shall not receive any portion of the running
         royalties as stated in Section 5.2, which running royalties shall
         remain unchanged; and

d)       the approving OWNERS authorize GI to grant to COMPANY the license
         according to Section 2.1; in countries where it is legally impossible
         to grant licenses to jointly owned patent rights without the approval
         of all joint owners, the approving OWNERS will partial assign their
         ownership position in the PATENT RIGHTS in such countries to COMPANY.

2. In the event that (i) one or more of the OWNERS do not approve the Plan
within 2 months after receiving the Plan, or (ii) one or more of the approving
OWNERS do not grant the second co-exclusive license to EuropeRNAi within one
month after incorporation of EuropeRNAi and the German AG/GmbH according to the
Plan:

a)       the non-approving and non-granting OWNERS shall be excluded from the
         EuropeRNAi-license agreement, in particular their ownership position in
         the PATENT RIGHTS shall be excluded from the PATENT RIGHTS;

b)       the non-approving and non-granting OWNERS do not receive any shares
         from EuropeRNAi; the shares stated in the EuropeRNAi-license agreement
         (equivalent to Section 5.1 of this Agreement) shall be reduced
         according to the proportional internal ownership of the non-approving
         OWNERS in the PATENT RIGHTS, and EuropeRNAi shall transfer the so
         determined reduced number of shares to the approving OWNERS;

c)       the non-approving and non-granting OWNERS shall retransfer to COMPANY
         65% of their shares received according to Section 5.1; in this event
         the non-approving and non-granting

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 25

<PAGE>

         OWNERS shall be entitled to grant one co-exclusive license to their
         ownership position in the PATENT RIGHTS to any European-based party of
         their choice;

d)       the non-approving and non-granting OWNERS shall not receive any portion
         of the running royalties according to the EuropeRNAi-license agreement
         (equivalent to Section 5.2 of this Agreement), which running royalties
         shall remain unchanged; and

e)       the approving OWNERS authorize GI to grant to EuropeRNAi the license
         according to the EuropeRNAi-license agreement (equivalent to Section
         2.1 of this Agreement); in countries where it is legally impossible to
         grant licenses to jointly owned patent rights without the approval of
         all joint owners, the approving OWNERS will partial assign their
         ownership position in the PATENT RIGHTS in such countries to
         EuropeRNAi.

                                                      Alnylam; GI 2716, 2782 ZTM
                                                          Dec. 19, 2002; page 26

<PAGE>

                                    AMENDMENT

         OF THE LICENSE AGREEMENT DATED DEC. 20, 2002 (THE "AGREEMENT")

                                     BETWEEN

                GARCHING INNOVATION GmBH, MUNICH, GERMANY ("GI")

                                       AND

            ALNYLAM PHARMACEUTICALS INC., CAMBRIDGE, USA ("COMPANY")

PREAMBLE

COMPANY and Ribopharma AG, Kulmbach, Germany ("Ribopharma") have signed a letter
of intent to combine their businesses by way of a merger, acquisition, cross
investment or any other way of transaction (collectively, the "Merger") to
achieve parallel equity ownership in both entities or a combined entity.

The parties to that transaction plan to have a parent holding company that will
own and control directly or indirectly the two existing entities COMPANY and
Ribopharma ("Hold Co."). The parent holding company shall be a US corporation.
This planned structure doesn't comply with certain of the requirements set forth
in Appendix C of the Agreement (the "REQUIREMENTS") on the assumption that
Ribopharma will be granted the second co-exclusive license described in Appendix
C. COMPANY wishes that the second co-exclusive license will be granted by GI to
Ribopharma.

Hold Co. and COMPANY have expressed their strong commitment that Ribopharma
shall be comparable to Alnylam, in particular in terms of growth, operational
forces and business capabilities, in the next five years. GI is willing to
support the Merger by amending certain REQUIREMENTS which are not in compliance
with the planned structuring of the transaction, if Hold Co. and COMPANY, on the
other hand, give GI greater security with respect to their commitment towards
Ribopharma.

Now, therefore, GI, COMPANY, and Hold Co. agree to amend and restate the
REQUIREMENTS to allow the execution of the Merger in compliance with the
Agreement on the following conditions:

The words in capital letters used in this Amendment shall have the meaning
defined in the Agreement.

A) GENERAL PROVISIONS

1.       COMPANY and GI agree that after the execution of the Merger, Ribopharma
         shall be regarded as the German AG or GmbH, which shall have comparable
         operational forces in terms of budget, employees, Research &
         Development and Business Development capacities as COMPANY for the next
         [**] in Germany. The split of indications according to Section 2.3 of
         the Agreement shall apply to COMPANY and Ribopharma.

                                                                          page 1

<PAGE>

2.       Due to time restrictions in the preparation of the Merger, COMPANY was
         only able to provide GI with a preliminary plan, which does not fulfil
         sufficiently REQUIREMENT No. 1 regarding the final Plan. GI and COMPANY
         agree that the signature of this Amendment shall be regarded as Plan
         approval by MAX PLANCK and a waiver of any failure of COMPANY to comply
         with the REQUIREMENTS regarding the Plan. Any of the other OWNERS shall
         only be regarded as an approving OWNER if it approves both the
         Agreement and this Amendment.

3.       GI agrees that the second co-exclusive license described in the
         Agreement will be granted by GI to Ribopharma (the
         "Ribopharma-License") contemporaneously with the closing of the Merger.
         The Ribopharma License shall include, without limitation, the following
         terms and conditions, and shall otherwise be comparable in scope and
         terms to the license granted by GI to COMPANY under the Agreement:

                  (a)      Ribopharma shall have no right to grant sublicenses
                  of its rights granted under the Ribopharma License to COMPANY,
                  Hold Co. or any affiliate or other company associated with the
                  Merger;

                  (b)      Any and each assignment of any rights and obligations
                           of the Ribopharma License by Ribopharma to COMPANY,
                           Hold Co. or any affiliate or any other company
                           associated with the Merger shall be subject to the
                           prior written approval of GI; and

                  (c)      Detailed definitions for "Affiliates" and for "Third
                           Parties".

                  (d)      In the event that one or more of the amended
                           REQUIREMENTS of this Amendment stated in B) to D)
                           below are not or no longer met by COMPANY, GI has the
                           extraordinary right to terminate the Ribopharma
                           License after compliance with the procedures set
                           forth in REQUIREMENT No. 5 c) below.

4.       All parties of the Merger acknowledge that they have each interests
         outside the FIELD of the Agreement. All parties of the Merger agree to
         maintain a periodic dialogue in good faith to discuss and potentially
         resolve any emerging commercial conflicts of interest outside the FIELD
         of the Agreement.

B) REQUIREMENT NO. 3 shall have the following wording:

"3. within three months after Plan approval:

         The OWNERS shall receive cost-free non-retransferable shares in Hold
         Co. of the same class that the Series B investors in COMPANY's Series B
         financing round will receive in Hold Co. in the course of the Merger,
         whereby the automatic conversion of Series B shares in Series B-1
         shares shall not apply to the OWNERS, and the OWNERS are not subject to
         the Special Mandatory Conversion as set forth in Article Fourth,
         Section 2(i) of the Certificate of Incorporation of Hold Co. as amended
         (the "Shares"). The Shares received by the OWNERS, as a group, shall be
         equivalent to 6% of COMPANY's total capital stock and equivalent to 6%
         of Ribopharma's total capital stock, each of the percentage of shares
         adjusted according to Appendix D2 in the event one or more OWNERS do
         not approve the Plan. For the avoidance of doubt, the approving OWNERS
         (MPG, MIT and WHITEHEAD) shall receive an equivalent number of shares
         in Hold-Co. as calculated in the capitalization tables of both COMPANY
         (723.240 Series B

                                                      Alnylam; GI 2716, 2782 ZTM
                                                           Dec. 19, 2002; page 2

<PAGE>

         shares) and Ribopharma (142.277 Series B shares). The total number of
         Shares the approving OWNERS shall receive in Hold-Co. is shown in the
         capitalization table of Hold Co. (865.517 Shares and 32.656 Additional
         Shares (as defined below in b)) The total capital stock of COMPANY,
         Ribopharma and Hold-Co. are attached to this Amendment as Appendixes 1,
         2 and 3.

         The total amount of Shares to be received by the OWNERS is subject to
         increase in an amount to be defined in good faith by the parties in the
         event that COMPANY:

         (a)      makes any cash payments to the shareholders of Ribopharma,
                  other than (i) payments (whether in the form of loans or cash)
                  for the payment of taxes incurred by such stockholders, (ii)
                  salary and bonus payments in connection with any employment
                  agreements with such stockholders, and (iii) payments made in
                  return for a reduction of shares having equal value to such
                  payment received or receivable in exchange for the
                  shareholding in Ribopharma in the Merger;

         (b)      executes or agrees to enter into a financing agreement prior
                  to the share transfer to the OWNERS pursuant to which the
                  investors in the financing receive shares at a price lower
                  than that paid for the Series B shares offered to the OWNERS
                  (US$ 2.50) in the Agreement.

                  For the avoidance of doubt, the parties already agreed that as
                  compensation for the 1,000,000 Series A shares Abingworth
                  receives at a price of US$ 1.00 per share prior to or in
                  connection with the Merger, the number of Shares the OWNERS
                  will receice shall be increased by cost-free
                  non-retransferable additional Shares in Hold Co. (the
                  "Additional Shares") as follows:

                  (i) 16,328 Additional Shares are due to the approving OWNERS
                  (MPG, MIT and WHITEHEAD) upon signature of the Ribopharma
                  License, and

                  (ii) 16,328 Additional Shares are due to the approving OWNERS
                  (MPG, MIT and WHITEHEAD) upon issuance of patent claims of the
                  MAX PLANCK PATENT RIGHTS in the United States which cover the
                  application of double stranded RNA molecules with a length of
                  19-23 nucleotides whereas at least one strand has a 3'-prime
                  overhang of minimum one nucleotide for the use in the field of
                  RNA interference.

         (c)      Other measures decreasing the value of the Shares in
                  connection with the transaction. If shares are allotted to
                  investors pursuant to the Merger on any basis different from
                  the combined capitalization table here attached, an
                  appropriate adjustment to the shares received by the OWNERS
                  will be made according to the above calculation.

C) REQUIREMENT NO. 5 shall have the following wording:

"5. after Plan approval and for [**] years after the EFFECTIVE DATE (the
"Period"):

a)  Hold Co. shall use reasonable commercial efforts to build for Ribopharma
    capabilities to develop, make, use, sell or import LICENSED PRODUCTS
    comparable to COMPANY. Ribopharma must have comparable operational forces in
    Germany in terms of budget, employees, Research & Development and Business
    Development capacities as COMPANY.

b)  As an exception, and not to limit the general rule set forth in 5. a) above,
    COMPANY may, in extraordinary business situations (with respect to
    importance and volume of the deal, such

                                                      Alnylam; GI 2716, 2782 ZTM
                                                           Dec. 19, 2002; page 3

<PAGE>

    as drug discovery and drug development deals with big pharma companies),
    make business decisions based on objective business reasons and on all
    reasonable care, which may have an adverse effect on the obligations set
    forth in 5. a) above, only if Hold Co. restores comparability at the
    earliest practical date and in the most efficient way. In the event that
    COMPANY acquires all or substantially all of the assets or shares of a third
    party in a transaction, the obligation to restore comparability set forth
    above shall not apply as to such transaction.

c)  GI shall have the right to request from Hold Co., at any time during the
    Period but not more than four times per year, a specific report (the
    "Report") showing how COMPANY and Ribopharma has fulfilled in the past and
    will fulfill within the Period its obligations specified in 5. a) and b)
    above. The Report shall include the general business objectives of COMPANY
    and Ribopharma and how COMPANY and Ribopharma intends to reach its
    objectives. Hold Co. has to deliver the Report to GI in writing within
    thirty (30) days after request in sufficient detail. GI shall notify Hold
    Co. within fifteen (15) days after receiving the Report if GI believes that
    COMPANY does not fulfill its obligations specified in 5. a) and b) above
    (the "Deficiency Notice"). Hold Co. shall, within thirty (30) days after
    receiving the Deficiency Notice, provide GI in writing with a detailed plan
    describing how Hold Co. proposes to achieve the compliance to fulfill within
    the Period its obligations specified in 5. a) and b) above, the specific
    goals to be met in order to achieve compliance, and the measures that Hold
    Co. will take in order to achieve compliance (the "Corrective Plan"). GI
    shall, within fifteen (15) days following receipt, either accept or reject
    the Corrective Plan. If GI accepts the Corrective Plan, Hold Co. shall
    implement the Corrective Plan within three (3) months after receiving GI's
    approval. If GI rejects the Corrective Plan, GI shall have the right to
    initiate arbitration according to Section 12.3, with the following
    modifications: all time limits shall be reduced by one half, the costs for
    such arbitration shall be borne by Hold Co. and GI according to their
    success. Hold Co. shall implement the award of the arbitrators within three
    (3) months. If GI believes that Hold Co. has not implemented the Corrective
    Plan or the award of the arbitrators, GI shall have the right to initiate
    the above described arbitration procedure to determine if Hold Co. has fully
    implemented the Corrective Plan or the award of the arbitrators. In the
    event that Hold Co. is judged to be in default of implementing, GI shall
    have the right to terminate the Ribopharma License immediately.

d)  All information provided by COMPANY in connection with this Amendment shall
    be treated as confidential by GI under Section 8.2 of the Agreement.

D) REQUIREMENT NO. 6 shall be deleted entirely.

However, in the event that COMPANY decides, within the Period, that COMPANY and
Ribopharma (or the then existing licensee of the second co-exclusive license)
shall be completely separate entities (regarding legal, business, financial and
any other issues), then, from the date such separation is executed, the original
wording of the REQUIREMENTS No. 5 and 6 shall return to force.

In witness whereof, the parties have caused this Amendment to be executed by
their duly authorized representatives.

Garching Innovation GmbH                  Alnylam Pharmaceuticals, Inc.

By:    /s/Bernard Hertel                  By:    /s/John Margaranore
       -----------------------------             -----------------------------
Name:  Dr. Bernhard Hertel                Name:  John Maraganore
Title: Geschaftsfuhrer                    Title: Chief Executive Officer
Date:  July 2, 2003                       Date:  July 8, 2003

                                                      Alnylam; GI 2716, 2782 ZTM
                                                           Dec. 19, 2002; page 4

<PAGE>

Hold Co., Inc.                                Ribopharma AG

By:    /s/John Margaranore          By:    /s/ Roland Kreutzer /s/ Stefan Limmer
       ------------------------            -------------------------------------
Name:  John Maraganore              Name:  Roland Kreutzer
Title: Chief Executive Officer      Title: Vorstand
Date:  July 8, 2003                 Date:  July 2, 2003

                                                Alnylam; GI 2716, 2782 ZTM
                                                     Dec. 19, 2002; page 5
<PAGE>

                            INDEMNIFICATION AGREEMENT

between

Garching Innovation GmbH,
a German corporation having a principal place of business at
Hofgartenstrasse 8, 80539 Munchen, Germany,
represented by the Managing Director, Dr. Bernhard Hertel,
hereinafter called "GI"-

and

Alnylam Pharmaceuticals Inc.,
a Delaware corporation having a principal place of business at
790 Memorial Drive, Suite 202, Cambridge, MA 02139, USA,
represented by the Chief Executive Officer, John Maraganore,
hereinafter called "COMPANY" -

PREAMBLE

Massachusetts Institute of Technology ("MIT"), Whitehead Institute for
Biomedical Research ("Whitehead"), Max-Planck-Gesellschaft zur Foerderung der
Wissenschaften e.V. ("MPG") and University of Massachusetts ("UMass"), are joint
owners of certain patent rights relating to "RNA Sequence-Specific Mediators of
RNA Interference", by David P. Bartel, Phillip A. Sharp, Thomas Tuschl, and
Phillip D. Zamore (PCT Publication No. WO 01/75164, hereinafter "Tuschl I", MPG
Case No. GI 2716 KTM).

MPG is the sole owner of certain patent rights relating to "RNA Interference
Mediating Small RNA Molecules," by Thomas Tuschl, Sayda Elbashir, and Winfried
Lendeckel (claims 1-29 of PCT Publication No. WO 02/44321, hereinafter "Tuschl
II", MPG Case No. GI 2782 KTM). MPG has authorized GI to act as its agent for
the purposes of licensing its ownership position of Tuschl I, and of licensing
Tuschl II.

COMPANY (formerly Alnylam Holding Co.) is the parent holding company of its two
subsidiaries Alnylam US, Cambridge, MA, USA (formerly Alnylam Pharmaceutical,
Inc.) and Alnylam Europe, Kulmbach, Germany (formerly Ribopharma AG). GI has
signed with each of Alnylam US and Alnylam Europe (collectively, the "GI
Licensees") a co-exclusive license regarding the use of Tuschl I and Tuschl II
for therapeutic purposes.

UMass has licensed its ownership position of Tuschl I to several licensees,
including Sirna Therapeutics, Boulder, CO, USA, (collectively, the "UMass
Licensees") for therapeutic purposes. In the course of the prosecution of Tuschl
I, certain data of Tuschl II, including data on 3' overhangs and on mammalian
cell activity, has been incorporated in Tuschl I, such incorporation was
initiated by Whitehead (hereinafter "Tuschl II Data"). The UMass Licensees claim
that they have rights, through their license to Tuschl I, to use the Tuschl II
Data to support and make certain claims in Tuschl I.

GI and COMPANY currently discuss reasonable actions of GI, or approval of
actions by GI, in connection with the ownership or inventorship of the Tuschl II
Data, including without limitation

                                                     Indemnification Tuschl I/II
                                                          April 22, 2004, page 1
<PAGE>

clarification that the inventive subject matter of Tuschl II cannot be claimed
in Tuschl I, and removal of the Tuschl II Data from Tuschl I, (collectively, the
"Tuschl I/II Matters").

GI is willing to actively support COMPANY to solve the Tuschl I/Tuschl II
Matters, but only if COMPANY bears the costs and indemnifies GI and MPG.

Now, therefore, COMPANY, acting in its own name and also in the name of Alnylam
US and Alnylam Europe, and GI hereby agree as follows:

1. Indemnification and Cost-Bearing

COMPANY shall, at its sole expense, indemnify, defend, and hold harmless MPG and
GI, and their trustees, officers, faculty, students, employees, and agents and
their respective successors, heirs and assigns (collectively, the
"Indemnitees"), against any liability, damage, loss, costs, fees or expense
(including reasonable attorneys fees and expenses) incurred by or imposed upon
any of the Indemnitees in connection with any claims, suits, actions, demands or
judgments (collectively, the "Claims") arising out of any theory of liability
(including without limitation actions in the form of tort, warranty, or strict
liability and regardless of whether such action has any factual basis) relating
to the Tuschl I/Tuschl II Matters

COMPANY shall pay to GI all reasonable costs, fees or expense (including without
limitation internal costs, e.g. travel expenses of the Indemnitees, and external
costs, e.g. attorneys fees) incurred by any of the Indemnitees relating to the
Tuschl I/Tuschl II Matters, within 30 days after receipt of the respective
invoice from GI.

COMPANY shall not be responsible for indemnifying the Indemnitees for any
actions of the Indemnitees, or any actions approved by the Indemnitees, that
occurred prior to the licensing of Tuschl I and Tuschl II to COMPANY.

COMPANY shall not be responsible for indemnifying the Indemnitees for any
actions of the Indemnitees, or any actions approved by the Indemnitees, judged
by a court of competent jurisdiction to be unlawful or fraudulent.

2. Procedures of Defense

The Indemnitees agree to provide COMPANY with written notice in due time of any
Claims for which indemnification is sought under Section 1 above. COMPANY
agrees, at its own expense, to provide attorneys reasonably acceptable to GI to
defend against any Claims. The Indemnitees shall cooperate fully with COMPANY in
such defense and will permit COMPANY to reasonably conduct such defense of
Claims (including all decisions relative to litigation, appeal, and settlement);
provided, however, that any Indemnitee shall have the right to retain its own
counsel, at the expense of COMPANY, if representation of such Indemnitee by the
counsel retained by COMPANY would be inappropriate because of actual or
potential differences in the interests of such Indemnitee and any other party
represented by such counsel. COMPANY shall keep GI informed of the progress in
the defense of Claims and shall consult with GI with regard to any proposed
settlement or any other decision on Claims. In no event may COMPANY compromise,
settle or otherwise dispose of any Claim without the prior written consent of
GI.

3. Term

This Agreement shall come into effect on April 1, 2004, and shall remain in
effect until the sooner of (i) all potential Claims relating to the Tuschl
I/Tuschl II Matters are expired, statute-barred, or otherwise finally not
enforceable against the Indemnitees, or (ii) ten years after the last action of
the Indemnitees, or the last action approved by the Indemnitees, relating to the
Tuschl I/II Matters has occurred.

                                                     Indemnification Tuschl I/II
                                                          April 22, 2004, page 2
<PAGE>

4. Assignment and Transfer

This Agreement is personal to COMPANY and no rights or obligations may be
assigned by COMPANY without the prior written consent of GI. COMPANY may assign
its rights and obligations under this Agreement to a legal successor in
connection with the merger, consolidation, or sale of all or substantially all
of its assets or that portion of its business to which this Agreement relates;
provided however that such successor has agreed towards GI in writing to be
bound by the terms and conditions of this Agreement. If such successor fails to
agree, COMPANY shall pay into escrow a one-time payment of USD 1.000.000 to
cover potential Claims for the term of this Agreement as defined in Section 3.

5. Governing Law

The parties explicitly agree and deem appropriate that this Agreement and all
disputes arising out of or related to this Agreement, or the performance,
enforcement, breach or termination hereof, and any remedies relating thereto,
shall be construed, governed, interpreted and applied in accordance with the
laws of the Federal Republic of Germany, except that questions affecting the
construction and effect of any patent shall be determined by the law of the
country in which the patent shall have been granted.

6. Amendment and Waiver

This Agreement may be amended, supplemented, or otherwise modified only by means
of a written instrument signed by both parties. Any waiver of any rights or
failure to act in a specific instance shall relate only to such instance and
shall not be construed as an agreement to waive any rights or fail to act in any
other instance, whether or not similar.

7. Severability

Should one of the provisions of this Agreement be held void, invalid or
unenforceable, the remaining provisions of this Agreement will not cease to be
effective. The parties shall negotiate in good faith to replace such void,
invalid or unenforceable provision by a new provision which reflects, to the
extent possible, the original intent of the parties.

In witness whereof, the parties have caused this Agreement to be executed by
their duly authorized representatives.

Garching Innovation GmbH                    Alnylam Pharmaceuticals, Inc.

By:      /s/ I.V. Maria Pasecky,            By:     /s/ John Maraganore
             I.V. Joem Erselius
         -----------------------------              -------------------
Name:    I.V. Maria Pasecky,                Name:   John Maraganore
         I.V. Joem Erselius on              Title:  Chief Executive Officer
         behalf of Dr. Bernhard Hertel
                                            Date:   April 23, 2004
                                                    --------------
Date:    April 23, 2004
         --------------

                                                     Indemnification Tuschl I/II
                                                          April 22, 2004, page 3<PAGE>

                                                                   Exhibit 10.26

                        1997 EDITION - ELECTRONIC FORMAT

                            AIA DOCUMENT A111 - 1997

STANDARD FORM OF AGREEMENT BETWEEN OWNER AND CONTRACTOR
where the basis for payment is the COST OF THE WORK PLUS A FEE with a negotiated
Guaranteed Maximum Price

AGREEMENT made as of the day of in the year
(In words, indicate day, month and year)
Twenty-sixth of March, two thousand and four

BETWEEN THE OWNER:
(Name, address and other information)

Alnylam Pharmaceuticals. Inc.
790 Memorial Drive, Suite 202
Cambridge, MA 02139

and the Contractor:
(Name, address and other information)
Perini Building Company, Inc.
73 Mt. Wayte Avenue
Framingham, MA 01701

The Project is:
(Name and location)
The Laboratory Tenant Fit-out of "Office Level 3", with required support spaces
on other floors as required, of 300 Third Street, Cambridge, MA 02142.

The Architect is:
(Name, address and other information)
Olson Lewis Dioli & Doktor
Architects & Planners
17 Elm Street
Manchester-by-the-Sea, MA 01944

The Owner and Contractor agree as follows.

ARTICLE 1 THE CONTRACT DOCUMENTS

         The Contract Documents consist of this Agreement, Conditions of the
         Contract (General, Supplementary and other Conditions), Drawings,
         Specifications, Addenda issued prior to execution of this Agreement,
         other documents listed in this Agreement and Modifications issued after
         execution of this Agreement; these form the Contract, and are as fully
         a part of the Contract as if attached to this Agreement or repeated
         herein. The Contract represents the entire and integrated agreement
         between the parties hereto and supersedes prior negotiations,
         representations or agreements, either written or oral. An enumeration
         of the Contract Documents, other than Modifications, appears in Article
         15. If anything in the other Contract Documents is inconsistent with
         this Agreement, this Agreement shall govern.

ARTICLE 2 THE WORK OF THIS CONTRACT

         The Contractor shall fully execute the Work described in the Contract
         Documents, except to the extent specifically indicated in the Contract
         Documents to be the responsibility of others.

ARTICLE 3 RELATIONSHIP OF THE PARTIES

---------------
(C)1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)I997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               1

<PAGE>

         The Contractor accepts the relationship of trust and confidence
         established by this Agreement and covenants with the Owner to cooperate
         with the Architect and exercise the Contractor's skill and judgment in
         furthering the interests of the Owner, to furnish efficient business
         administration and supervision; to furnish at all times an adequate
         supply of workers and materials; and to perform the Work in an
         expeditious and economical manner consistent with the Owner's
         interests. The Owner agrees to furnish and approve, in a timely manner,
         information required by the Contractor and to make payments to the
         Contractor in accordance with the requirements of the Contract
         Documents.

         3.1.4    Nothing contained in the contract shall be deemed to propose
         general design responsibilities on the General Contractor.

ARTICLE 4 DATE OF COMMENCEMENT AND SUBSTANTIAL COMPLETION

         4.1      The Work commenced on 11/20/2003.

         4.2      The Contractor shall achieve Substantial Completion of the
         entire Work not later than May 14, 2004.

         subject to adjustments of this Contract Time as provided in the
         Contract Documents.
         (Insert provisions, if any, for liquidated damages relating to failure
         to complete on time, or for bonus payments for early completion of the
         Work.)

ARTICLE 5 BASIS FOR PAYMENT

         5.1      CONTRACT SUM

         5.1.1    The Owner shall pay the Contractor the Contract Sum in current
         funds for the Contractor's performance of the Contract. The Contract
         Sum is the Cost of the Work as defined in Article 7 plus the
         Contractor's Fee.

         5.1.2    The Contractor's Fee is the lump sum of: $232,565

         For changes in the Work, the Fee shall be adjusted by 5.5% of the net
         value of the Change Order for increases in the Cost of the Work. No Fee
         shall be deducted for net decreases in the Cost of the Work.
         Subcontractors shall be allowed a 12% overhead and fee on Change Order
         work.

         5.1.3    The estimated Cost of the Work is $ 5,168,104

         5.2      Guaranteed Maximum Price.

         5.2.1    The sum of the Cost of the Work and the Contractor's Fee is
         guaranteed by the Contractor not a exceed FIVE MILLION FOUR HUNDRED
         THOUSAND SIX HUNDRED SIXTY NINE DOLLARS

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute or Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               2

<PAGE>

         $5,400,669 subject to additions and deductions by Change Order as
         provided in the Contract Documents. Such maximum sum is referred to in
         the Contract Documents as the Guaranteed Maximum Price. Costs that
         would cause the Guaranteed Maximum Price to be exceeded shall be paid
         by the Contractor without reimbursement by the Owner, except to the
         extent that the bonus available under Clause 5.2.1.1 causes an increase
         in the Fee, and, accordingly, the Guaranteed Maximum Price, taking into
         consideration the provisions of Clause 5.2.1.3.

         1.       If the Contractor achieves Substantial Completion of the Work
         by April 30, 2004, the Contractor shall be entitled to an increase in
         the Contractor's Fee of one percent (1%) of the actual Cost of the
         Work, plus an additional Fee of One Thousand Dollars ($1,000.00) per
         calendar day that Substantial Completion is achieved prior to April 30,
         2004.

         2.       If the Contractor fails to achieve Substantial Completion by
         May 14, 2004. the Contractor's Fee shall be reduced by One Thousand
         Dollars ($1,000.00) per calendar day that Substantial Completion is
         delayed beyond May 14, 2004, provided that such reduction shall not
         exceed 50% of the Contractor's Fee. Liquidated damages are in lieu of
         actual or consequential damages.

         3.       If the Contractor completes the Work for less than the
         estimated Cost of the Work, as such Cost may be modified by Change
         Orders, then the Contractor shall be entitled to an additional
         Contractor's Fee in an amount equal to 25% of the difference between
         the estimated Cost of the Work and the actual Cost of the Work,
         provided that the Contractor has achieved Substantial Completion of the
         Work within the Contract Time, as the Contract Time may be modified by
         Change Orders.

         5.2.2    The Guaranteed Maximum Price is based on the following
         alternates, if any, which are described in the Contract Documents and
         are hereby accepted by the Owner:

         (State the numbers or other identification of accepted alternates. If
         decisions on other alternates are to be made by the Owner subsequent to
         the execution of this Agreement, attach a schedule of such other
         alternates showing the amount for each and the date when the amount
         expires.)

         1) 05120 PCO#5 added steel add $136,381.00.

         2) 12345 Cold Room add $71,000.00.

         3) Partial taxes add $22,627.00 per Exhibit C.

         4) Cost for Addendum #1 add $36,525.00 per Exhibit D.

         5.2.3    Unit prices, if any, are as follows:

         5.2.4    Allowances, if any, are as follows:

         (Identify and state the amounts of any allowances, and state whether
         they include labor, materials, or both.)

---------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution.

WARNING: Unlicensed photocopying violates U.S. copyright laws and will subject
the violator to legal prosecution. This document was electronically produced
with permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylam.aia - 3/1/2004. AIA License Number 1029845,
which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               3

<PAGE>

         07250 - Roofing - $15,000,00.

         09600 - 830 square feet Epoxy Flooring - $20,750.00.

         0000 - Fire Extinguishers - $5,000.00.

         2345 - Cold Room - $71,000,00.

         4000 - Elevator Operator - $20,000,00.

         Insurance $73,319.00.

         Allowances to be adjusted up or down by change order.

         5.2.5    Assumptions, if any, on which the Guaranteed Maximum Price is
         based are as follows:

         Materials and equipment purchased for the laboratory components of the
         project is exempt from sales tax per Exhibit "C". See Attached. GMP
         contingency is to be used by Contractor at his discretion to make up
         for, but not limited to. Contractors errors, omission, schedule
         acceleration for Perini to achieve schedule dates, not to include major
         changes by the Owner, and gaps only if due to Perini's fault in the
         GMP. The Contractor shall notify the Owner as to its use of contingency
         at the time of each requisition, and shall provide a full account of
         the use of the contingency to the Owner upon final completion of the
         Work.

         5.2.6    To the extent that the Drawings and Specifications are
         anticipated to require further development by the Architect, the
         Contractor has provided in the Guaranteed Maximum Price for such
         further development consistent with the Contract Documents and
         reasonably inferable therefrom. Such further development does not
         include such things as changes in scope, systems, kinds and quality of
         materials, finishes or equipment, all of which, if required, shall be
         incorporated by Change Order.

ARTICLE 6 CHANGES IN THE WORK

         6.1      Adjustments to the Guaranteed Maximum Price on account of
         changes in the Work may be determined by any of the methods listed in
         Subparagraph 7.3.3 of AIA Document A201-1997.

         6.2      In calculating adjustments to subcontracts (except those
         awarded with the Owner's prior consent on the basis of cost plus a
         fee), the terms "cost" and "fee" as used in Clause 7.3.3.3 of AIA
         Document A201-1997 and the terms "costs" and "a reasonable allowance
         for overhead and profit" as used in Subparagraph 7.3.6 of AIA Document
         A201-1997 shall have the meanings assigned to them in AIA Document
         A201-1997 and shall not be modified by Articles 5,7 and 8 of this
         Agreement. Adjustments to subcontracts awarded with the Owner's prior
         consent on the basis of cost plus a fee shall be calculated in
         accordance with the terms of those subcontracts.

         6.3      In calculating adjustments to the Guaranteed Maximum Price,
         the terms "cost" and "costs" as used in the above-referenced provisions
         of AIA Document A201-1997 shall mean the Cost of the Work as defined in
         Article 7 of this Agreement and the terms "fee" and "a reasonable
         allowance for overhead and profit" shall mean the Contractor's Fee as
         defined in Subparagraph 5.1.2 of this Agreement.

         6.4      If no specific provision is made in Paragraph 5.1 for
         adjustment of the Contractor's Fee in the case of changes in the Work,
         or if the extent of such changes is such, in the aggregate, that
         application of the adjustment provisions of Paragraph 5.1 will cause
         substantial inequity to the Owner or Contractor, the Contractor's Fee
         shall be equitably adjusted on the basis of the Fee established for the
         original Work, and the Guaranteed Maximum Price shall be adjusted
         accordingly.

ARTICLE 7 COSTS TO BE REIMBURSED

         7.1      COST OF THE WORK

         The term Cost of the Work shall mean costs necessarily incurred by the
         Contractor in the proper performance of the Work. Such costs shall be
         at rates not higher than the standard paid at the place of the Project
         except with prior consent of the Owner. The Cost of the Work shall
         include only the items set forth in this Article 7.

         7.2      LABOR COSTS

------------------
(C) 192O, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)I997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington. D.C. 20006-5292

                                                                               4

<PAGE>

         7.2.1    Wages of construction workers directly employed by the
         Contractor to perform the construction of the Work at the site or, with
         the Owner's approval, at off-site workshops.

         7.2.2    Wages or salaries of the Contractor's supervisory and
         administrative personnel when stationed at the site with the Owner's
         approval.

         (If it is intended that the wages or salaries of certain personnel
         stationed at the Contractor's principal or other offices shall be
         included in the Cost of the Work, identify in Article 14 the personnel
         to be included and whether for all or only part of their time, and the
         rates at which their time will be charged to the Work.)

         7.2.3    Wages and salaries of the Contractor's supervisory or
         administrative personnel engaged, at factories, workshops or on the
         road, in expediting the production or transportation of materials or
         equipment required for the Work, but only for that portion of their
         time required for the Work.

         7.2.4    Costs paid or incurred by the Contractor for taxes, insurance,
         contributions, assessments and benefits required by law or collective
         bargaining agreements and, for personnel not covered by such
         agreements, customary benefits such as sick leave, medical and health
         benefits, holidays, vacations and pensions, provided such costs are
         based on wages and salaries included in the Cost of the Work under
         Subparagraphs 7.2.1 through 7.2.3.

         7.3      SUBCONTRACT COSTS

         7.3.1    Payments made by the Contractor to Subcontractors in
         accordance with the requirements of the subcontracts.

         7.4      COSTS OF MATERIALS AND EQUIPMENT INCORPORATED IN THE COMPLETED
         CONSTRUCTION

         7.4.1    Costs, including transportation and storage, of materials and
         equipment incorporated or to be incorporated in the completed
         construction.

         7.4.2    Costs of materials described in the preceding Subparagraph
         7.4.1 in excess of those actually installed to allow for reasonable
         waste and spoilage. Unused excess materials, if any, shall become the
         Owner's property at the completion of the Work or, at the Owner's
         option, shall be sold by the Contractor. Any amounts realized from such
         sales shall be credited to the Owner as a deduction from the Cost of
         the Work.

         7.5      COSTS OF OTHER MATERIALS AND EQUIPMENT, TEMPORARY FACILITIES
         AND RELATED ITEMS

         7.5.1    Costs, including transportation and storage, installation,
         maintenance, dismantling and removal of materials, supplies, temporary
         facilities, machinery, equipment, and hand tools not customarily owned
         by construction workers, that are provided by the Contractor at the
         site and fully consumed in the performance of the Work; and cost (less
         salvage value) of such items if not fully consumed, whether sold to
         others or retained by the Contractor. Cost for items previously used by
         the Contractor shall mean fair market value.

         7.5.2    Rental charges for temporary facilities, machinery, equipment,
         and hand tools not customarily owned by construction workers that are
         provided by the Contractor at the site, whether rented from the
         Contractor or others, and costs of transportation, installation, minor
         repairs and replacements, dismantling and removal thereof. Rates and
         quantities of equipment rented shall be subject to the Owner's prior
         approval.

         7.5.3    Costs of removal of debris from the site.

         7.5.4    Costs of document reproductions, facsimile transmissions and
         long-distance telephone calls, postage and parcel delivery charges,
         telephone service at the site and reasonable petty cash expenses of the
         site office.

-------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               5

<PAGE>

         7.5.5    That portion of the reasonable expenses of the Contractor's
         personnel incurred while traveling in discharge of duties connected
         with the Work.

         7.5.6    Costs of materials and equipment suitably stored off the site
         at a mutually acceptable location, if approved in advance by the Owner.

         7.6      MISCELLANEOUS COSTS

         7.6.1    That portion of insurance and bond premiums that can be
         directly attributed to this Contract:

         7.6.2    Sales, use or similar taxes imposed by a governmental
         authority that are related to the Work.

         7.6.3    Fees and assessments for the building permit and for other
         permits, licenses and inspections for which the Contractor is required
         by the Contract Documents to pay.

         7.6.4    Fees of laboratories for tests required by the Contract
         Documents, except those related to defective or nonconforming Work for
         which reimbursement is excluded by Subparagraph 13.5.3 of AIA Document
         A201-1997 or other provisions of the Contract Documents, and which do
         not fall within the scope of Subparagraph 7.7.3.

         7.6.5    Royalties and license fees paid for the use of a particular
         design, process or product required by the Contract Documents; the cost
         of defending suits or claims for infringement of patent rights arising
         from such requirement of the Contract Documents; and payments made in
         accordance with legal judgments against the Contractor resulting from
         such suits or claims and payments of settlements made with the Owner's
         consent. However, such costs of legal defenses, judgments and
         settlements shall not be included in the calculation of the
         Contractor's Fee or subject to the Guaranteed Maximum Price. If such
         royalties, fees and costs are excluded by the last sentence of
         Subparagraph 3.17.1 of AIA Document A201-1997 or other provisions of
         the Contract Documents, then they shall not be included in the Cost of
         the Work.

         7.6.6    Data processing costs related to the Work.

         7.6.7    Deposits lost for causes other than the Contractor's
         negligence or failure to fulfill a specific responsibility to the Owner
         as set forth in the Contract Documents.

         7.6.8    Legal, mediation and arbitration costs, including attorneys'
         fees, other than those arising from disputes between the Owner and
         Contractor, or arising from the negligence of Contractor, Subcontractor
         or Supplier, reasonably incurred by the Contractor in the performance
         of the Work and with the Owner's prior written approval; which approval
         shall not be unreasonably withheld.

         7.6.9    Expenses incurred in accordance with the Contractor's standard
         personnel policy for relocation and temporary living allowances of
         personnel required for the Work, if approved by the Owner.

         7.7      OTHER COSTS AND EMERGENCIES

         7.7.1    Other costs incurred in the performance of the Work if and to
         the extent approved in advance in writing by the Owner.

         7.7.2    Costs due to emergencies incurred in taking action to prevent
         threatened damage, injury or loss in case of an emergency affecting the
         safety of persons and property, as provided in Paragraph 10.6 of AIA
         Document A201-1997.

-------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               6

<PAGE>

         7.7.3    Costs of repairing or correcting damaged or nonconforming Work
         executed by the Contractor, Subcontractors or suppliers, provided that
         such damaged or nonconforming Work was not caused by negligence or
         failure to fulfill a specific responsibility of the Contractor and only
         to the extent that the cost of repair or correction is not recoverable
         by the Contractor from insurance, sureties, Subcontractors or
         suppliers.

         7.7.4    Costs of repairing Work damaged by the Owner or by parties not
         employed by the Contractor, Subcontractor or Supplier.

ARTICLE 8 COSTS NOT TO BE REIMBURSE

         8.1      The Cost of the Work shall not include:

         8.1.1    Salaries and other compensation of the Contractor's personnel
         stationed at the Contractor's principal office or offices other than
         the site office, except as specifically provided in Subparagraphs 7.2.2
         and 7.2.3 or as may be provided in Article 14.

         8.1.2    Expenses of the Contractor's principal office and offices
         other than the site office.

         8.1.3    Overhead and general expenses, except as may be expressly
         included in Article 7.

         8.1.4    The Contractor's capital expenses, including interest on the
         Contractor's capital employed for the Work.

         8.1.5    Rental costs of machinery and equipment, except as
         specifically provided in Subparagraph 7.5.2.

         8.1.6    Except as provided in Subparagraph 7.7.3 of this Agreement,
         costs due to the negligence or failure to fulfill a specific
         responsibility of the Contractor, Subcontractors and suppliers or
         anyone directly or indirectly employed by any of them or for whose acts
         any of them may be liable.

         8.1.7    Any cost not specifically and expressly described in
         Article 7.

         8.1.8    Costs, other than costs included in Change Orders approved by
         the Owner, that would cause the Guaranteed Maximum Price to be
         exceeded.

ARTICLE 9 DISCOUNTS, REBATES AND REFUNDS

         9.1      Cash discounts obtained on payments made by the Contractor
         shall accrue to the Owner if (1) before making the payment, the
         Contractor included them in an Application for Payment and received
         payment therefor from the Owner, or (2) the Owner has deposited funds
         with the Contractor with which to make payments; otherwise, cash
         discounts shall accrue to the Contractor. Trade discounts, rebates,
         refunds and amounts received from sales of surplus materials and
         equipment shall accrue to the Owner, and the Contractor shall make
         provisions so that they can be secured.

         9.2      Amounts that accrue to the Owner in accordance with the
         provisions of Paragraph 9.1 shall be credited to the Owner as a
         deduction from the Cost of the Work.

ARTICLE 10 SUBCONTRACTS AND OTHER AGREEMENTS

         10.1     Those portions of the Work that the Contractor does not
         customarily perform with the Contractor's own personnel shall be
         performed under subcontracts or by other appropriate agreements with
         the Contractor. The Owner may designate specific persons or entities
         from whom the Contractor shall obtain bids. The Contractor shall obtain
         bids from Subcontractors

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general condition!
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT Alll - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               7

<PAGE>

         and from suppliers of materials or equipment fabricated especially for
         the Work and shall deliver such bids to the Architect. The Owner shall
         then determine, with the advice of the Contractor and the Architect,
         which bids will be accepted. The Contractor shall not be required to
         contract with anyone to whom the Contractor has reasonable objection.

         10.2     If a specific bidder among those whose bids are delivered by
         the Contractor to the Architect (i) is recommended to the Owner by the
         Contractor, (2) is qualified to perform that portion of the Work; and
         (3) has submitted a bid that conforms to the requirements of the
         Contract Documents without reservations or exceptions, but the Owner
         requires that another bid be accepted, then the Contractor may require
         that a Change Order be issued to adjust the Guaranteed Maximum Price by
         the difference between the bid of the person or entity recommended to
         the Owner by the Contractor and the amount of the subcontract or other
         agreement actually signed with the person or entity designated by the
         Owner.

         10.3     Subcontracts or other agreements shall conform to the
         applicable payment provisions of this Agreement, and shall not be
         awarded on the basis of cost plus a fee without the prior consent of
         the Owner.

ARTICLE 11 ACCOUNTING RECORDS

         The Contractor shall keep full and detailed accounts and exercise such
         controls as may be necessary for proper financial management under this
         Contract, and the accounting and control systems shall be satisfactory
         to the Owner. The Owner and the Owner's accountants shall be afforded
         access to, and shall be permitted to audit and copy, the Contractor's
         records, books, correspondence, instructions, drawings, receipts,
         subcontracts, purchase orders, vouchers, memoranda and other data
         relating to this Contract, and the Contractor shall preserve these for
         a period of three years after final payment, or for such longer period
         as may be required by law. The Contractor shall separately account for
         costs incurred in the performance of that portion of the work
         identified by the Owner as "Lab Areas" on Exhibit.

ARTICLE 12 PAYMENTS

         12.1     PROGRESS PAYMENTS
         12.1.1   Based upon Applications for Payment submitted to the Architect
         by the Contractor and Certificates for Payment issued by the Architect,
         the Owner shall make progress payments on account of the Contract Sum
         to the Contractor as provided below and elsewhere in the Contract
         Documents.

         12.1.2   The period covered by each Application for Payment shall be
         one calendar month ending on the last day of the month, or as follows:
         The Owner shall provide Contractor with Owner's tax exempt certificate
         together with a list of fixtures, equipment and materials to which the
         tax exemption indicated in Exhibit "C" attached herein. The Owner
         hereby designates the Contractor as its Agent in making the purchases
         of any such tax exempt items.

         12.1.3   Provided that an Application for Payment is received by the
         Architect not later than the tenth day of a month, the Owner shall
         make payment to the Contractor not later than the tenth day of the
         following month. If an Application for Payment is received by the
         Architect after the application date fixed above, payment shall be made
         by the Owner not later than thirty days after the Architect receives
         the Application for Payment.

         12.1.4   With each Application for Payment, the Contractor shall submit
         payrolls, petty cash accounts, receipted invoices or invoices with
         check vouchers attached, and any other evidence required by the Owner
         or Architect to demonstrate that cash disbursements already made by the
         Contractor on account of the Cost of the Work equal or exceed (i)
         progress payments already received by the Contractor, less (2) that
         portion of those payments attributable to the Contractor's Fee; plus
         (3) payrolls for the period covered by the present Application for
         Payment.

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)I997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               8

<PAGE>

         12.1.5   Each Application for Payment shall be based on the most recent
         schedule of values submitted by the Contractor in accordance with the
         Contract Documents. The schedule of values shall allocate the entire
         Guaranteed Maximum Price among the various portions of the Work, except
         that the Contractor's Fee shall be shown as a single separate item. The
         schedule of values shall be prepared in such form and supported by such
         data to substantiate its accuracy as the Architect may require. This
         schedule, unless objected to by the Architect, shall be used as a basis
         for reviewing the Contractor's Applications for Payment.

         12.1.6   Applications for Payment shall show the percentage of
         completion of each portion of the Work as of the end of the period
         covered by the Application for Payment. The percentage of completion
         shall be the lesser of (i) the percentage of that portion of the Work
         which has actually been completed; or (2) the percentage obtained by
         dividing (a) the expense that has actually been incurred by the
         Contractor on account of that portion of the Work for which the
         Contractor has made or intends to make actual payment prior to the next
         Application for Payment by (b) the share of the Guaranteed Maximum
         Price allocated to that portion of the Work in the schedule of values.

         12.1.7   Subject to other provisions of the Contract Documents, the
         amount of each progress payment shall be computed as follows:

            .1    take that portion of the Guaranteed Maximum Price properly
                  allocable to completed Work as determined by multiplying the
                  percentage of completion of each portion of the Work by the
                  share of the Guaranteed Maximum Price allocated to that
                  portion of the Work in the schedule of values. Pending final
                  determination of cost to the Owner of changes in the Work,
                  amounts not in dispute shall be included as provided in
                  Subparagraph 7.3.8 of AIA Document A201-1997;

            .2    add that portion of the Guaranteed Maximum Price properly
                  allocable to materials and equipment delivered and suitably
                  stored at the site for subsequent incorporation in the Work,
                  or if approved in advance by the Owner, suitably stored off
                  the site at a location agreed upon in writing;

            .3    add the Contractor's Fee Contractor's General Conditions, less
                  retainage of zero percent ( 0 %). The Contractor's Fee shall
                  be computed upon the Cost of the Work described in the two
                  preceding Clauses at the rate stated in Subparagraph 5.1.2 or,
                  if the Contractor's Fee is stated as a fixed sum in that
                  Subparagraph, shall be an amount that bears the same ratio to
                  that fixed-sum fee as the Cost of the Work in the two
                  preceding Clauses bears to a reasonable estimate of the
                  probable Cost of the Work upon its completion;

            .4    subtract the aggregate of previous payments made by the Owner;

            .5    subtract the shortfall, if any, indicated by the Contractor in
                  the documentation required by Paragraph 12.1.4 to substantiate
                  prior Applications for Payment, or resulting from errors
                  subsequently discovered by the Owner's accountants in such
                  documentation; and

            .6    subtract amounts, if any, for which the Architect has withheld
                  or nullified a Certificate for Payment as provided in
                  Paragraph 9.5 of AIA Document A201-1997.

         12.1.8   Except with the Owner's prior approval, payments to
         Subcontractors shall be subject to retainage of not less than ten
         percent (10%). The Owner and the Contractor shall agree upon a mutually
         acceptable procedure for review and approval of payments and retention
         for

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)I997 AIA(R)
AIA DOCUMENT Alll - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               9

<PAGE>

         Subcontractors. Retainage may be reduced to 5% upon 50% completion on a
         case-by-case, at the sole discretion of the Owner.

         12.1.9   In taking action on the Contractor's Applications for Payment,
         the Architect shall be entitled to rely on the accuracy and
         completeness of the information furnished by the Contractor and shall
         not be deemed to represent that the Architect has made a detailed
         examination, audit or arithmetic verification of the documentation
         submitted in accordance with Subparagraph 12.1.4 or other supporting
         data; that the Architect has made exhaustive or continuous on-site
         inspections or that the Architect has made examinations to ascertain
         how or for what purposes the Contractor has used amounts previously
         paid on account of the Contract. Such examinations, audits and
         verifications, if required by the Owner, will be performed by the
         Owner's accountants acting in the sole interest of the Owner.

         12.2     FINAL PAYMENT

         12.2.1   Final payment, constituting the entire unpaid balance of the
         Contract Sum, shall be made by the Owner to the Contractor when:

                  .1       the Contractor has fully performed the Contract
                           except for the Contractor's responsibility to correct
                           Work as provided in Subparagraph 12.2.2 of AIA
                           Document Aaoi-1997, and to satisfy other
                           requirements, if any, which extend beyond final
                           payment; and

                  .2       a final Certificate for Payment has been issued by
                           the Architect.

         12.2.2   The Owner's final payment to the Contractor shall be made no
         later than 30 days after the issuance of the Architect's final
         Certificate for Payment, or as follows:

         12.2.3   The Owner's accountants will review and report in writing on
         the Contractor's final accounting within 30 days after delivery of the
         final accounting to the Architect by the Contractor. Based upon such
         Cost of the Work as the Owner's accountants report to be substantiated
         by the Contractor's final accounting, and provided the other conditions
         of Subparagraph 12.2.1 have been met, the Architect will, within seven
         days after receipt of the written report of the Owner's accountants,
         either issue to the Owner a final Certificate for Payment with a copy
         to the Contractor, or notify the Contractor and Owner in writing of the
         Architect's reasons for withholding a certificate as provided in
         Subparagraph 9.5.1 of the ALA Document A201-1997. The time periods
         slated in this Subparagraph 12.2.3 supersede those stated in
         Subparagraph 9.4.1 of the AIA Document A201-1997.

         12.2.4   If the Owner's accountants report the Cost of the Work as
         substantiated by the Contractor's final accounting to be less than
         claimed by the Contractor, the Contractor shall be entitled to file a
         claim, such claim shall be made by the Contractor within 30 days after
         the Contractor's receipt of a copy of the Architect's final Certificate
         for Payment; failure to make a claim within this 30-day period shall
         result in the substantiated amount reported by the Owner's accountants
         becoming binding on the Contractor. Pending a final resolution by
         arbitration, the Owner shall pay the Contractor the amount certified in
         the Architect's final Certificate for Payment.

         12.2.5   If, subsequent to final payment and at the Owner's request,
         the Contractor incurs costs described in Article 7 and not excluded by
         Article 8 to correct defective or nonconforming Work, the Owner shall
         reimburse the Contractor such costs and the Contractor's Fee applicable
         thereto on the same basis as if such costs had been incurred prior to
         final payment, but not in excess of the Guaranteed Maximum Price. If
         the Contractor has participated in savings as provided in Paragraph
         5.2, the amount of such savings shall be recalculated and appropriate

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general condition!
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT Alll - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              10

<PAGE>

         credit given to the Owner in determining the net amount to be paid by
         the Owner to the Contractor.

ARTICLE 13 TERMINATION OR SUSPENSION

         13.1     The Contract may be terminated by the Contractor, or by the
         Owner for convenience, as provided in Article 14 of AIA Document
         A201-1997. However, the amount to be paid to the Contractor under
         Subparagraph 14.1.3 of AIA Document A201-1997 shall not exceed the
         amount the Contractor would be entitled to receive under Paragraph 13.2
         below, except that the Contractor's Fee shall be calculated as if the
         Work had been fully completed by the Contractor, including a reasonable
         estimate of the Cost of the Work for Work not actually completed.

         13.2     The Contract may be terminated by the Owner for cause as
         provided in Article 14 of AIA Document A201-1997. The amount, if any,
         to be paid to the Contractor under Subparagraph 14.2.4 of AIA Document
         A201-1997 shall not cause the Guaranteed Maximum Price to be exceeded,
         nor shall it exceed an amount calculated as follows:

         13.2.1   Take the Cost of the Work incurred by the Contractor to the
         date of termination;

         13.2.2   Add the Contractor's Fee computed upon the Cost of the Work to
         the date of termination at the rate stated in Subparagraph 5.1.2 or, if
         the Contractor's Fee is stated as a fixed sum in that Subparagraph, an
         amount that bears the same ratio to that fixed-sum Fee as the Cost of
         the Work at the time of termination bears to a reasonable estimate of
         the probable Cost of the Work upon its completion; and

         13.2.3   Subtract the aggregate of previous payments made by the Owner.

         13.3     The Owner shall also pay the Contractor fair compensation,
         either by purchase-or rental at the election of the Owner, for any
         equipment owned by the Contractor that the Owner elects to retain and
         that is not otherwise included in the Cost of the Work under
         Subparagraph 13.2.1. To the extent that the Owner elects to take legal
         assignment of subcontracts and purchase orders (including rental
         agreements), the Contractor shall, as a condition of receiving the
         payments referred to in this Article 13, execute and deliver all such
         papers and take all such steps, including the legal assignment of such
         subcontracts and other contractual rights of the Contractor, as the
         Owner may require for the purpose of fully vesting in the Owner the
         rights and benefits of the Contractor under such subcontracts or
         purchase orders.

         13.4     The Work may be suspended by the Owner as provided in Article
         14 of AIA Document A201-1997; in such case, the Guaranteed Maximum
         Price and Contract Time shall be increased as provided in Subparagraph
         14.3.2 of AIA Document A201-1997 except that the term "profit" shall
         be understood to mean the Contractor's Fee as described in
         Subparagraphs 5.1.2 and Paragraph 6.4 of this Agreement.

ARTICLE 14 MISCELLANEOUS PROVISIONS

         14.1     Where reference is made in this Agreement to a provision AIA
         Document A201-1997 or another Contract Document, the reference refers
         to that provision as amended or supplemented by other provisions of the
         Contract Documents.

         14.2     Payments due and unpaid under the Contract shall bear interest
         from the date payment is due at the rate staled below, or in the
         absence thereof, at the legal rate prevailing from time to time at the
         place where the Project is located.
         (Insert rate of interest agreed upon, if any.)

         Payments due and unpaid for more than thirty (30) days under the
         Contract Documents shall bear interest at the prime rate published from
         time to time in the WSJ.

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              11

<PAGE>
         (Usury laws and requirements under the Federal Truth in Lending Act,
         similar state and local consumer credit laws and other regulations at
         the Owner's and Contractor's principal places of business, the location
         of the Project and elsewhere may affect the validity of this provision.
         Legal advice should be obtained with respect to deletions or
         modifications, and also regarding requirements such as written
         disclosures or waiver as.)

         14.3     THE OWNER'S REPRESENTATIVE IS:
         (Name, address and other in formation.)
         Richard D. Priester
         Strategic Facility Planning LLC
         102 Loker Street
         Wayland, MA 01778

         14.4     The Contractor's representative is:
         (Name, address and other information.)
         Matthew Collins
         73 Mt. Wayte Avenue
         Framingham, MA 01701-9160

         14.5     Neither the Owner's nor the Contractor's representative shall
         be changed without ten days' written notice to the other party.

         14.6     Other provisions:

         14.6.1   The wages of the following employees shall be included in the
         Cost of the Work when those employees are working directly on the
         Project at the site office:

         Matthew Collins, Project Executive

         Deborah Avery, Project Manager

         Joseph Jowkar, Superintendent

         The wages of these employees shall not exceed the rates/amounts set
         forth in Attached Rates.

         The Contractor shall not make changes in the above personnel without
         the consent of the Owner, consent which shall not be unreasonably
         withheld.

         14.16.2  The Contractor shall provide to the Owner at Final Completion
         a set of marked up as built plans for the Work reflecting all of
         Contractor's field notations and Change Orders.

ARTICLE 15 ENUMERATION OF CONTRACT DOCUMENTS

         15.1     The Contract Documents, except for Modifications issued after
         execution of this Agreement, are enumerated as follows:

         15.1.1   The Agreement is this executed 1997 edition of the Standard
         Form of Agreement Between Owner and Contractor, AIA Document A111
         -1997, 18 pages*.

         15.1.2   The General Conditions are the 1997 edition of the General
         Conditions of the Contract for Construction, AIA Document A201-1997;
         47 pages *.

         * Page counts may be modified in final versions.

         15.1.3   The Supplementary and other Conditions of the Contract are as
         follows:

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below. expiration as noted below. User Document: alnylam.aia - 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington. D.C. 20006-5292

                                                                              12

<PAGE>

         Document                Title                 Pages                Date

         See Exhibit A list of documents.

         15.1.4   The Specifications are as follows:
         (Either list the Specifications here or refer to an exhibit attached to
         this Agreement.)

         Section                 Title                 Pages                Date

         See Exhibit A list of documents.

         15.1.5   The Drawings are as follows, and are dated unless a different
         date is shown below:
         (Either list the Drawings here or refer to an exhibit attached to this
         Agreement.)

         Number                  Title                 Date

         See Exhibit A list of documents (2 pages).

         15.1.6   The Addenda, if any, are as follows:

         Number                  Title                 Pages

         None included.

         Portions of Addenda relating to bidding requirements are not part of
         the Contract Documents unless the bidding requirements are also
         enumerated in this Article 15.

         15.1.7   Other Documents, if any, forming part of the Contract
         Documents are as follows:
         (List here any additional documents, such as a list of alternates that
         are intended to form part of the Contract Documents. AIA Document
         A201-1997 provides that bidding requirements such as advertisement or
         invitation to bid, Instructions to Bidders, sample Arms and the
         Contractor's bid are not part of the Contact Documents unless
         enumerated in this Agreement. They should be listed here only if
         intended to be part of the Contract Documents.)

ARTICLE 16 INSURANCE AND BONDS

         (List required limits of liability for insurance and bonds. AIA
         Document A201-1997 gives other specific requirements for insurance and
         bonds.)

         See attached Perini Insurance Certificate - Exhibit B.

ARTICLE 17 MISCELLANEOUS EXHIBITS

Exhibit C taxes added to project which do not qualify as tax exempt (2 pages).
Exhibit D breakdown of cost (2 pages).

This Agreement is entered into as of the day and year first written above and is
executed in at least three original copies, of which one is to be delivered to
the Contractor, one to the Architect for use in the administration of the
Contract, and the remainder to the Owner.

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general conditions
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              13

<PAGE>

/s/ Barry Greene                     /s/ Sam Sabin
---------------------------          -----------------------
OWNER (Signature)                    CONTRACTOR (Signature)

BARRY GREENE, COO                    SAM SABIN SR VP
---------------------------          ------------------------
(Printed name and title)             (Printed name and title)

----------------
(C) 1920, 1925, 1951, 1961, 1963, 1967, 1974, 1978, 1987, (C) 1997 by The
American Institute of Architects. Reproduction of the material herein or
substantial quotation of its provisions without written permission of the AIA
violates the copyright laws of the United States and will subject he violate to
legal prosecution. WARNING: Unlicensed photocopying violates U.S. copyright laws
and will subject the violator to legal prosecution. This document was
electronically produced with permission of the AIA and can be reproduced in
accordance with your license without violation until the date of expiration as
noted below, expiration as noted below. User Document: alnylam.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document is not intended for use in competitive bidding.

AIA Document A201-1997, General Conditions of the Contract for Construction, is
adopted in this document by reference. Do not use with other general condition
unless this document is modified.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A111 - 1997
OWNER - CONTRACTOR AGREEMENT

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              14

<PAGE>

ALNYLAM - DOCUMENT LIST                                              Exhibit "A"
                                                                          Page 1

<TABLE>
<CAPTION>
Dwq.#   Title                                               Date        Revision
-----   -----                                               ----        --------
<S>     <C>                                                 <C>         <C>
-       Cover Sheet                                         11/11/03    -

        ARCHITECTURAL

A1.0    Office Level 3 - Existing Floor Plan                11/11/03    -
A1.1    Office Level 3 - Proposed Floor Plan                11/11/03    -
A1.2    Parking Level P1/P2 - Proposed Partial Plans        11/11/03    -
A1.3    Office Level 3 - Equipment Plan                     11/11/03    -
A1.4    Office Level 3 - Casework Plan                      11/11/03    -
A1.5    Office Level 3 - Dimension Plan                     11/11/03    -
A1.6    Door Schedules / Door Types                         11/11/03    -
A1.7    Finish Schedule                                     11/11/03    -
A4.0    Finish Plan                                         11/11/03    -
A4.1    Painting Plan                                       11/11/03    -
A5.0    Laboratory Casework Elevations                      11/11/03    -
A5.1    Laboratory Casework Elevations                      11/11/03    -
A5.2    Interior Elevations / Casework Details              11/11/03    -
A6.0    Office Level 3 - Reflected Ceiling Plan             11/11/03    -
A9.0    Proposed Misc. Details & Sections                   11/11/03    -
A9.1    Wall Details                                        11/11/03    -
A9.2    Millwork Details                                    11/11/03    -
A9.3    Millwork Details                                    11/11/03    -
A9.4    Millwork Details                                    11/11/03    -

        STRUCTURAL

S-1     General Notes and Typical Details                   11/11/03    -
S-2     Mechanical Platform Framing Plan                    11/11/03    -
S-3     Sections and Details                                11/11/03    -

        FIRE PROTECTION

FP0.1   Fire Protection Legend                              11/11/03    -
FP1.1   Fire Protection Office Level 3 Plan                 11/11/03    -
FP1.2   Fire Protection Parking Level Part. Plans           11/11/03    -

        FIRE ALARM

FA0.1   Fire Alarm Legend                                   11/11/03    -
FA1.1   Fire Alarm Office Level 3 Plan                      11/11/03    -
FA1.2   Fire Alarm Parking Level Part. Plans                11/11/03    -

        PLUMBING

P0.1    Plumbing Legend, Diagrams and Mezzanine Part-Plan   11/11/03    -
P1.1    Plumbing Parking Level 1 (P1) Plan                  11/11/03    -
P1.2    Plumbing Parking Level 2 (P2) Plan                  11/11/03    -
P1.3    Plumbing Office Level 1 (O1) Plan                   11/11/03    -
P1.4    Plumbing Office Level 2 (O2) Plan                   11/11/03    -
P1.5A   Plumbing Office Level 3 (O3) Part Plan 'A'          11/11/03    -
P1.5B   Plumbing Office Level 3 (O3) Part Plan 'B'          11/11/03    -
P1.5C   Plumbing Office Level 3 (03) Part Plan 'C'          11/11/03    -
P1.5D   Plumbing Office Level 3 (O3) Part Plan 'D'          11/11/03    -
P1.6    Plumbing Office Level 4 (O4) Plan                   11/11/03    -
P1.7    Plumbing Penthouse & Roof Level                     11/11/03    -
</TABLE>

<PAGE>

<TABLE>
Dwq.#   Title                                               Date        Revision
-----   -----                                               ----        --------
<S>     <C>                                                 <C>         <C>
        HVAC

H0.1    HVAC Legend and General Notes                       11/11/03    -
H0.2    HVAC Schedules                                      11/11/03    -
H0.3    HVAC Details                                        11/11/03    -
H1.1    HVAC Parking Levels Part Plans                      11/11/03    -
H1.2    HVAC Office Level 3 Ductwork Plan                   11/11/03    -
H1.3    HVAC Office Level 3 Piping Plan                     11/11/03    -
H1.4    HVAC Roof Plan                                      11/11/03    -

        ELECTRICAL

E 0.1   Electrical Legend, Notes and Schedules              11/11/03    -
E 1.1   Office Level 3 Electrical Lighting Plan             11/11/03    -
E 1.2   Office Level 3 Electrical Power Plan                11/11/03    -
E 1.3   Parking Level 1 and 2 Electrical Lighting/Power
        Plans                                               11/11/03    -
E 1.4   Roof Level Electrical Lighting/Power Plan           11/11/03    -
E 2.1   Electrical Power Riser Diagram                      11/11/03    -
E 2.2   Electrical Schedules and Details                    11/11/03    -
E 2.3   Electrical Schedules and Details                    11/11/03    -

        SPECIFICATIONS

        Section 15300 - Fire Protection                     10/10/03    -
        Section 15400 - Plumbing                            10/10/03    -
        Section 15500 - HVAC                                11/11/03    -
        Section 16000 - Electrical                          10/10/03    -
        Section 16700 - Fire Alarm                          10/10/03    -
</TABLE>

<PAGE>
                                  [ILLEGIBLE]

<TABLE>
<S>                                                         <C>
PRODUCER                                                    THIS CERTIFICATE IS ISSUED AS A MATTER OF INFORMATION
  Aon Risk Services, Inc. of Massachusetts                  ONLY AND CONFERS NO RIGHTS UPON THE CERTIFICATE
  99 High Street                                            HOLDER. THIS CERTIFICATE DOES NOT AMEND. EXTEND OR
  Boston MA 02110                                           ALTER THE COVERAGE AFFORDED BY THE POLICIES BELOW.
                                                            -----------------------------------------------------
                                                                        COMPANIES AFFORDING COVERAGE
                                                            -----------------------------------------------------
                                                            COMPANY     Insurance Company of the State of PA
PHONE - (617) 482-3100 FAX - (617) 542-2597                     A
-----------------------------------------------------------------------------------------------------------------
INSURED                                                     COMPANY    National Union Fire Ins Co of Pittsburgh
  Perini Building Company, Inc.                                 B
  73 Mt Wayte Avenue                                        -----------------------------------------------------
  Framinghan MA 01701-9160 USA                              COMPANY    American Home Assurance Co.
                                                                C
                                                            -----------------------------------------------------
                                                            COMPANY
                                                                D                                     EXHIBIT "B"
-----------------------------------------------------------------------------------------------------------------
</TABLE>

COVERAGES

THIS IS TO CERTIFY THAT THE POLICIES OF INSURANCE LISTED BELOW HAVE BEEN ISSUED
TO THE INSURED NAMED ABOVE FOR THE POLICY PERIOD INDICATED, NOTWITHSTANDING ANY
REQUIREMENT. TERM OR CONDITION OF ANY CONTRACT OR OTHER DOCUMENT WITH RESPECT TO
WHICH THIS CERTIFICATE MAY BE ISSUED OR MAY PERTAIN. THE INSURANCE AFFORDED BY
THE POLICIES DESCRIBED HEREIN IS SUBJECT TO ALL THE TERMS, EXCLUSIONS AND
CONDITIONS OF SUCH POLICIES. LIMITS SHOWN MAY HAVE BEEN REDUCED BY PAID CLAIMS.

<TABLE>
<CAPTION>
                                                               POLICY      POLICY
                                                             EFFECTIVE   EXPIRATION
CO                                                              DATE        DATE
LIR             TYPE OF INSURANCE           POLICY NUMBER    (MM/DD/YY)  (MM/DD/YY)                     LIMITS
------------------------------------------------------------------------------------------------------------------------------
<S>  <C>                                  <C>                <C>         <C>          <C>
A    GENERAL LIABILITY                    GL 9332360 Master   12/31/02    12/31/03    GENERAL AGGREGATE            $ 4,000,000
                                                                                      ----------------------------------------
     [X] COMMERCIAL GENERAL LIABILITY     General Liability                           PRODUCTS - COMP/OP AGG       $ 4,000,000
                                                                                      ----------------------------------------
     [ ] CLAIMS MADE  [X] OCCUR                                                       PERSONAL & ADV INJURY        $ 2,000,000
                                                                                      ----------------------------------------
     [ ] OWNER'S CONTRACTOR'S PROT                                                    EACH OCCURRENCE              $ 2,000,000
                                                                                      ----------------------------------------
     [ ]                                                                              FIRE DAMAGE (Any one fire)   $ 2,000,000
         -------------------------------                                              ----------------------------------------
     [ ]                                                                              MED EXP (Any one person)     $    10,000
------------------------------------------------------------------------------------------------------------------------------
C    AUTOMOBILE LIABILITY                 AL8261281           12/31/02    12/31/03
     [X] ANY AUTO                         Automobile-MA                               COMBINED SINGLE LIMIT        $ 2,000,000

     [X] ALL OWNED AUTOS                                                              ----------------------------------------

     [X] SCHEDULED AUTOS                                                              BODILY INJURY
                                                                                      (Per person)
     [X] HIRED AUTOS
                                                                                      ----------------------------------------
     [X] NON-OWNED AUTOS
                                                                                      BODILY INJURY
     [ ]
         -------------------------------
     [ ]                                                                              ----------------------------------------

                                                                                      PROPERTY DAMAGE

------------------------------------------------------------------------------------------------------------------------------
     GARAGE LIABILITY                                                                 AUTO ONLY - EA ACCIDENT
                                                                                      ----------------------------------------
     [ ] ANY AUTO                                                                     OTHER THAN AUTO ONLY:
                                                                                      ----------------------------------------
     [ ]                                                                                      EACH ACCIDENT
         -------------------------------                                              ----------------------------------------
     [ ]                                                                                      AGGREGATE
------------------------------------------------------------------------------------------------------------------------------
B    EXCESS LIABILITY                     BE2859979           12/31/02    12/31/03    EACH OCCURRENCE              $ 5,000,000
                                          Lead Umbrella                               ----------------------------------------
     [X] UMBRELLA FORM                                                                AGGREGATE                    $ 5,000,000
                                                                                      ----------------------------------------
     [ ] OTHER THAN UMBRELLA FORM                                                     Retained Limit Amount        $    10,000
------------------------------------------------------------------------------------------------------------------------------
A    WORKER'S COMPENSATION AND            WC7085528           12/31/02    12/31/03     X WC STATU-    OTH
     EMPLOYERS' LIABILITY                 Master Work Corp                               TORY LIMTS    ER
                                                                                      ----------------------------------------
     THE PROPRIETOR/            [ ]INCL                                               EL EACH ACCIDENT             $ 1,000,000
     PARTNER/EXECUTIVE                                                                ----------------------------------------
     OFFICERS ARE               [ ]EXCL                                               EL DISEASE-POLICY LIMIT      $ 1,000,000
                                                                                      ----------------------------------------
                                                                                      EL DISEASE-EA EMPLOYEE       $ 1,000,000
------------------------------------------------------------------------------------------------------------------------------

------------------------------------------------------------------------------------------------------------------------------
</TABLE>

DESCRIPTION OF OPERATIONS/LOCATIONS/VEHICLES/SPECIAL ITEMS

300 THIRD AVENUE, CAMBRIDGE, MA. ALNYLAM HOLDING COMPANY, ALNYLAM
PHARMACEUTICALS, INC. THE BEAL COMPANIES, CORNERSTONE REAL ESTATE ADVISERS, INC.
AND PALM, INC. ARE INCLUDED AS ADDITIONAL INSURED UNDER THE GENERAL LIABILITY AS
REQUIRED BY WRITTEN CONTRACT. WAIVER OF SUBROGATION APPLIES AS REQUIRED BY
WRITTEN CONTRACT.

CERTIFICATE HOLDER                        CANCELLATION

   STRATEGIC FACILITY PLANNING LLC        SHOULD ANY OF THE ABOVE DESCRIBED
   102 LOKER STREET                       POLICES BE CANCELLED BEFORE THE
   WAYLAND MA 01778 USA                   EXPIRATION DATE THEREOF. THE ISSUING
                                          COMPANY WILL ENDEAVOR TO MAIL 30 DAYS
                                          WRITTEN NOTICE TO THE CERTIFICATE
                                          HOLDER NAMED TO THE LEFT, BUT FAILURE
                                          TO MAIL SUCH NOTICE SHALL IMPOSE NO
                                          OBLIGATION OR LIABILITY OF ANY KIND
                                          UPON THE COMPANY. ITS AGENTS OR
                                          REPRESENTATIVES.

                                          AUTHORIZED REPRESENTATIVE

                                          /s/ [ILLEGIBLE]

<PAGE>

                                                                     Exhibit "C"
                                                                     Page 1

                                 PCO 2 SATES TAX

<TABLE>
<CAPTION>
                                       SUBCONTRACT                             BUYOUT SALES                 SUBCONTRACT  BUYOUT TAX
DIVISION                                 AMOUNT         GMP         STATUS          TAX      GMP SALES TAX    CHANGES       TOTAL
-----------------------------------------------------------------------------------------------------------------------------------
<S>                                    <C>          <C>          <C>           <C>           <C>            <C>          <C>
0700  GENERAL CONDITIONS                            $279,050.00
                                                                      N/A                                                $     0.00

02220 SELECTIVE DEMOLITION                          $  5,000.00
                                                                      N/A                                                     $0.00

05100 STRUCTURAL STEEL
      Equipment Platforms              $131,319.00  $136.381.00     Exempt       Included      Included     ($1,990.00)       $0.00

06100 ROUGH CARPENTRY
      Rough Carpentry                    In 09250                 Non-Exempt     in 09250      In 09250      In 09250     In 09250

06200 FINISH CARPENTRY
      Millwork                         $ 65,058.00  $187,000.00   Non-Exempt     Included                                $ 1,098.00

0720O ROOFING
      Roof Patching                                 $ 15,000.00   Non-Exempt                   Allowance

08700 DOORS AND HARDWARE
      Doors and Hardware               $ 70,485.00  $ 76,000.00   Non-Exempt     Included      Included                  $ 2,647.00

08800 GLASS AND GLAZING
      Glass And Glazing                $ 77,704.00  $151,000,00   Non-Exempt     Included      Included                  $ 2,100.00
      Sliding Glass Doors at Cagewash  $ 12,500.00                  Exempt       Excluded                                $     0.00

09250 GYPSUM DRYWALL
      Gypsum Drywall and Framing       $217,075.00  $193,600.00   Non-Exempt     Excluded      Included      $3.473.00   $ 3,473.00

09300 ACOUSTICAL CEILINGS
      Acoustic Ceilings                $ 55,800.00  $ 56,600.00   Non-Exempt     Included      Excluded                  $ 1,025.00

09500 FLOORING
      Carpet and VCT                   $117,158.00  $116,700.00   Non-Exempt     Included      Excluded                  $ 2,252.00
      Sheet Vinyl                       In Above      In Above      Exempt       Included      Included     ($  573.00)  $     0.00
      Epoxy Floor                      $  5,790.00  $ 20,750.00     Exempt       Excluded      Allowance                 $     0.00

09910 PAINTING
      Paint and Wallcoverings          $ 44,778.00   $41,500.00   Non-Exempt     Included      Excluded                  $   394.00

10000 SPECIALTIES
</TABLE>

Perini Building Co.                Page 1 of 2

<PAGE>

                                                                     Exhibit "C"
                                                                     Page 2

                                 PCO 2 SALES TAX

<TABLE>
<CAPTION>
                                       SUBCONTRACT                               BUYOUT SALES                SUBCONTRACT  BUYOUT TAX
DIVISION                                 AMOUNT            GMP         STATUS        TAX      GMP SALES TAX    CHANGES      TOTAL
------------------------------------------------------------------------------------------------------------------------------------
<S>                                    <C>            <C>            <C>         <C>           <C>           <C>          <C>
      Wall Guards                      $    3,900.00                   Exempt      Excluded                               $     0.0
      Eliason Door                     $    1,504.00                   Exempt      Excluded                               $     0.00
      Fire Extinguishers and Cabinets  $    1,612.00  $    5,000.00  Non-Exempt    Included     Allowance                 $    77.00
      Cylinder Racks                   $      787.00                   Exempt      Excluded                               $     0.00

12000 EQUIPMENT
      Cold Room                        $   83,143.00  $   71,000.00    Exempt      Excluded                               $     0.00
      Laboratory Casework              $  372,185.00  $  623.000.00    Exempt      Excluded     Excluded                  $     0.00

14000 ELEVATOR
      Operator                                        $   20,000.00      N/A         N/A        Allowance        N/A         N/A

15300 FIRE PROTECTION
      Sprinklers                       $   49,000.00  $   43,500.00  Non-Exempt    Excluded     Included     $  2,500.00  $ 2,500.00

15400 PLUMBING
      Plumbing                         $  754,653.00  $  766,250.00    Exempt      Excluded     Excluded                  $     0.00

15500 HVAC
      HVAC                             $1,243,375.00  $1,287,800.00    Exempt      Excluded     Excluded                  $     0.00

16000 ELECTRICAL
      Power                            $  746,000.00  $  791,870.00    Exempt      Excluded     Included                  $     0.00
      Lighting                                                       Non-Exempt    Excluded                  $  6,703.00  $ 6,703.00
      Fire Alarm                                                     Non-Exempt    Excluded                  $    358.00  $   358.00
                                       =============  =============                                          ===========  ==========
                                       $4,053,837.00  $4,887,901.00                                          $ 10,471.00  $22,627.00
                                       =============  =============                                          ===========  ==========
</TABLE>

Perini Building Co.                Page 2 of 2

<PAGE>

                                                                     Exhibit "D"
                                                                     Page 1

PROJECT NAME: ALNYLAM NEW LABORATORIES AND OFFICES
PROJECT LOCATION: 300 THIRD STREET, CAMBRIDGE, MA

BID DATE: 11/14/03 2:00 PM
MAIN SUMMARY SHEET:

                        PROJECT DURATION:       25 wks
                        PROJECT SF:         40000 Sqft

<TABLE>
<CAPTION>
                                                                   LUMP SUM
                                                                  BID AMOUNT
SPEC                  DESCRIPTION                                    TOTAL            %                     SUBS
------------------------------------------------------------------------------------------------------------------------------------
<S>                                                          <C>                   <C>        <C>
00700  General Conditions                                                 279,950      0%
02220  Selective Demolition                                                 5,000      0%     Perini
05120  Structural Steel (included In Palm scope of work)                  136,381      0%     PCO#5
06100  Rough Carpentry                                       in 09250                  0%
06200  Finish Carpentry                                                   187,000      0%     ACM
07250  Roofing                                                             15,000      0%     allowance / include waterproofing duct
08110  Steel Doors and Frames - Furnish                                    50,000      0%     O'Conner
       Steel Doors and Frames - Install                                    26,000      0%     Perini
08710  Door Hardware                                         in above                  0%     Perini
08800  Glass and Glazing                                                  151,000      0%     Salem
09250  Gypsum Drywall                                                     193,600      0%     Save-on
09300  Suspended Acoustical Ceilings                                       56,600      0%     K&K
09400  Carpet and Base                                                    116,700      0%     Independent
09500  Sheet Vinyl                                           in carpet                 0%     Independent
09600  Epoxy Flooring                                                      20,750      0%     Allowance 830 SF.  $25
09910  Painting                                                            41,500      0%     Egan
10000  Fire Extinguisher and Cabinet - Furnish                              2,500      0%     Allowance
       Fire Extinguisher and Cabinet - Install                              2,500      0%     Allowance
12345  Laboratory Case work.                                              623,000      0%     Longo
       Lab equipment excluded                                excluded                  0%     By Owner
       cold room excluded                                                  71,000      0%     By Owner
14000  Elevator                                                            20,000             operator allowance
15300  Fire Protection                                                     43,500      0%     JCH
15400  Plumbing                                                           766,250      0%     Gallagher
15500  Heating, Ventilation, and Air Conditioning                       1,287,600      0%     FHM
       Controls                                              in 15500
       Independent commissioning                             excluded                  0%     By Owner
16000  Electrical                                                         791,870      0%     Ostro
                                                                                       0%
       PERFORMANCE + PAYMENT BONDS FOR SUBS                                            0%     INCLUDED IN ABOVE
                                                                        =========  =====
                                                   SUBTOTAL             4,887,901
                                                                        =========
                                     TOTAL PROJECTED BUYOUT
                                                                        =========
                                        SUB TOTAL w/ BUYOUT             4,887,901
                                                                        =========
                                            BALANCE FORWARD             4,887,901
                                                                        =========
       BONDS ON SUBCONTRACTORS                               in above              0.015
       INSURANCE                                                           73,319
       MA Sales Tax                                                        22,627
       Overtime Allowance                                    excluded
       Addendum 1 Upgrade                                                  36,525
   3%  Contingency                                                        147,733
                                                                        =========
                                      SUBTOTAL w/ INSURANCE             5,168,104
                                                                        =========
4.50%  FEE-FIXED                                                          232,565  Fixed Fee
                                                                        =========
                                            SUBTOTAL w/ FEE             5,400,699
                                                                        =========

       PERFORMANCE & PAYMENT BOND EXCLUDED                   Excluded                0.0%
       PERINI'S BOND PREMIUM 1st $7,500,000
       PERINI'S BOND PREMIUM over 1st $7,500,000
                                                                        =========
                                          SUBTOTAL w/ BONDS             5,400,669
                                                                        =========
       BUILDING PERMITS & FEES                               By Owner
       FIRE DEPT CONSTRUCTION FEES                                             NA
       APPLICATION FEE (Flat Rate @ $130)                                      NA
        ADDTN FEES ($4.00/5.000cf of Floor Area)                               NA
        ADDTN FEES ($ 17.00/Ft Above 3rd Floor)                                NA
       DUMPSTER FEES                                                           NA
        $35.00/mo for 1st 3 months                                             NA
        $420.00 from 4th mo for up to 1 yr                                     NA
       SPRINKLER SYSTEMS                                                       NA
        ($70.00/permit for up to 1 yr)                                         NA
       ASBESTOS REMOVAL                                                        NA
        ($15.00/permit for 30 dys - max $180.00/yr)                            NA
       GASES PERMITS FEES (Acetylene & Propane)                                NA
                                                                        =========
                                                TOTAL PRICE             5,400,669
                                                                        =========
</TABLE>

<PAGE>

                                                                     EXHIBIT "D"
                                                                     PAGE 2

                               ADDENDUM 1 UPCHARGE

<TABLE>
<CAPTION>
                 DIVISION                            BUDGET/QUOTE          COST              SUBTOTAL
-------------------------------------------------------------------------------------------------------
<S>                                                <C>                 <C>                  <C>
06200 FINISH CARPENTRY
                                                   Compare to
        Cabinets in Community Space                Original Budget     $       0.00
        Board Room Details
        Reception Desk, Sign Wall, Coat Rack
        Details
                                                                                            $      0.00
08800 GLASS AND GLAZING
        Delete Frosted Glass Signage               Deduct Alt         ($   1,200.00)
        Substitute 1/2" glass for 5/8"                                ($  39,943.00)

                                                                                           ($ 41,143.00)
09250 GYPSUM DRYWALL
        Ceiling Soffits / Wall Details             Bid                 $   5,500.00
                                                                                            $  5,500.00
09500 FLOORING
                                                   Compare to
        Change of product specified.               Original Budget     $     459.00
        Floor patterns identified

                                                                                            $    459.00
09910 PAINTING
        Epoxy Paint                                Add/Alt             $   4,200.00

                                                                                            $  4,200.00
12345 LABORATORY CASEWORK
        Surgery Suites                             Add/Alt             $  17,500.00
        SS Counters w/integral sinks               Add/Alt             $   1,950.00
        Scope Room                                 Add/Alt             $   2,650.00
                                                                                            $ 22,100.00
15000 PLUMBING & MECHANICAL
        Piping Changes                             PCO Pricing        ($   5,913.09)
        Ductwork                                   PCO Pricing         $  43,201.20
        Automatic Temperature Controls             PCO Pricing         $   8,121.39
                                                                                            $ 45,409.50
                                                                                            -----------
                                                                             TOTAL:         $ 36,525.50
                                                                                            ===========
</TABLE>

Perini Building Company, Inc.                Page 1 of 1

<PAGE>

                                      1997 EDITION - ELECTRONIC FORMAT

                                                         AIA DOCUMENT A201 -1997

GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

TABLE OF ARTICLES

  1. GENERAL PROVISIONS

  2. OWNER

  3. CONTRACTOR

  4. ADMINISTRATION OF THE CONTRACT

  5. SUBCONTRACTORS

  6. CONSTRUCTION BY OWNER OR BY SEPARATE CONTRACTORS

  7. CHANGES IN THE WORK

  8. TIME

  9. PAYMENTS AND COMPLETION

  10. PROTECTION OF PERSONS AND PROPERTY

  11. INSURANCE AND BONDS

  12. UNCOVERING AND CORRECTION OF WORK

  13. MISCELLANEOUS PROVISIONS

  14. TERMINATION OR SUSPENSION OF THE CONTRACT

INDEX

Acceptance of Nonconforming Work
    9.6.6, 9.9.3, 12.3
Acceptance of Work
    9.6.6, 9.8.2, 9.9.3, 9.10.1, 9.10.3, 12.3
Access to Work
    3.16, 6.2.1, 12.1
Accident Prevention
    4.2.3, 10
Acts and Omissions
    3.2, 3.3.2, 3.12.8, 3.18, 4.2.3, 4.3.8, 4.4.1, 8.3.1, 9.5.1, 10.2.5, 13.4.2,
    13.7, 14.1
Addenda
    1.1.1, 3.11
Additional Costs, Claims for
    4.3.4, 4.3.5, 4.3.6, 6.1.1, 10.3
Additional Inspections and Testing
    9.8.3, 12.2.1, 13.5
Additional Time, Claims for
    4.3.4, 4.3.7, 8.3.2
ADMINISTRATION OF THE CONTRACT
    3.1.3, 4, 9.4, 9.5
Advertisement or Invitation to Bid
   1.1.1

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
Provisions without written permission of the AIA violates the copyright laws of
the united states and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA license number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT
D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               1

<PAGE>

Aesthetic Effect
    4.2.13, 4.5.1
Allowances
     3.8
All-risk Insurance
    11.4.1.1
Applications for Payment
    4.2.5, 7.3.8, 9.2, 9.3, 9.4, 9.5.1, 9.6.3, 9.7.1, 9.8.5, 9.10, 11.1.3,
    14.2.4, 14.4.3
Approvals
    2.4, 3.1.3, 3.5, 3.10.2, 3.12, 4.2.7, 9.3.2, 13.4.2, 13.5
Arbitration
    4.3.3, 4.4, 4.5.1, 4.5.2, 4.6, 8.3.1, 9.7.1, 11.4.9, 11.4.10
Architect
    4.1
Architect, Definition of
    4.1.1
Architect, Extent of Authority
    2.4, 3.12.7, 4.2, 4.3.6, 4.4, 5.2, 6.3, 7.1.2, 7.3.6, 7.4, 9.2, 9.3.1, 9.4,
    9.5, 9.8.3, 9.10.1, 9.10.3, 12.1, 12.2.1, 13.5.1, 13.5.2, 14.2.2, 14.2.4
Architect, Limitations of Authority and Responsibility
    2.1.1, 3.3.3, 3.12.4, 3.12.8, 3.12.10, 4.1.2, 4.2.1, 4.2.2, 4.2.3, 4.2.6,
    4.2.7, 4.2.10, 4.2.12, 4.2.13, 4.4, 5.2.1, 7.4, 9.4.2, 9.6.4, 9.6.6
Architect's Additional Services and Expenses
    2.4, 11.4.1.1, 12.2.1, 13.5.2, 13.5.3, 14.2.4
Architect's Administration of the Contract
    3.1.3, 4.2, 4.3.4, 4.4, 9.4, 9.5
Architect's Approvals
    2.4, 3.1.3, 3.5.1, 3.10.2, 4.2.7
Architect's Authority to Reject Work
    3.5.1, 4.2.6, 12.1.2, 12.2.1
Architect's Copyright
     1.6
Architect's Decisions
    4.2.6, 4.2.7, 4.2.11, 4.2.12, 4.2.13, 4.3.4, 4.4.1, 4.4.5, 4.4.6, 4.5, 6.3,
    7.3.6, 7.3.8, 8.1.3, 8.3.1, 9.2, 9.4, 9.5.1, 9.8.4, 9.9.1, 13.5.2, 14.2.2,
    14.2.4
Architect's Inspections
    4.2.2, 4.2.9, 4.3.4, 9.4.2, 9.8.3, 9.9.2, 9.10.1, 13.5
Architect's Instructions
    3.2.3, 3.3.1, 4.2.6, 4.2.7, 4.2.8, 7.4.1, 12.1, 13.5.2
Architect's Interpretations
    4.2.11, 4.2.12, 4.3.6
Architect's Project Representative
    4.2.10
Architect's Relationship with Contractor
    1.1.2, 1.6, 3.1.3, 3.2.1, 3.2.2, 3.2.3, 3.3.1, 3.4.2, 3.5.1, 3.7.3, 3.10,
    3.11, 3.12, 3.16, 3.18, 4.1.2, 4.1.3, 4.2, 4.3.4, 4.4.1, 4.4.7, 5.2, 6.2.2,
    7, 8.3.1, 9.2, 9.3, 9.4, 9.5, 9.7, 9.8, 9.9, 10.2.6, 10.3, 11.3, 11.4.7, 12,
    13.4.2, 13.5
Architect's Relationship with Subcontractors
    1.1.2, 4.2.3, 4.2.4, 4.2.6, 9.6.3, 9.6.4, 11.4.7
Architect's Representations
    9.4.2, 9.5.1, 9.10.1
Architect's Site Visits
    4.2.2, 4.2.5, 4.2.9, 4.3.4, 9.4.2, 9.5.1, 9.9.2, 9.10.1, 13.5
Asbestos
    10.3.1
Attorneys' Fees
    3.18.1, 9.10.2, 10.3.3
Award of Separate Contracts
    6.1.1, 6.1.2
Award of Subcontracts and Other Contracts for Portions of the Work
    5.2
Basic Definitions
    1.1
Bidding Requirements
    1.1.1, 1.1.7, 5.2.1, 11.5.1
Boiler and Machinery Insurance
    11.4.2
Bonds, Lien
    9.10.2
Bonds, Performance, and Payment
    7.3.6.4, 9.6.7, 9.10.3, 11.4.9, 11.5
Building Permit
    3.7.1
Capitalization
     1.3
Certificate of Substantial Completion
    9.8.3, 9.8.4, 9.8.5
Certificates for Payment
    4.2.5, 4.2.9, 9.3.3, 9.4, 9.5, 9.6.1, 9.6.6, 9.7.1, 9.10.1, 9.10.3, 13.7,
    14.1.1.3, 14.2.4
Certificates of Inspection, Testing or Approval
    13.5.4
Certificates of Insurance
    9.10.2, 11.1.3
Change Orders
    1.1.1, 2.4.1, 3.4.2, 3.8.2.3, 3.11.1, 3.12.8, 4.2.8, 4.3.4, 4.3.9, 5.2.3,
    7.1, 7.2, 7.3, 8.3.1, 9.3.1.1, 9.10.3, 11.4.1.2, 11.4.4, 11.4.9, 12.1.2
Change Orders, Definition of
    7.2.1
CHANGES IN THE WORK
    3.11, 4.2.8, 7, 8.3.1, 9.3.1.1, 11.4.9
Claim, Definition of
    4.3.1
Claims and Disputes
    3.2.3, 4.3, 4.4, 4.5, 4.6, 6.1.1, 6.3, 7.3.8, 9.3.3, 9.10.4, 10.3.3
Claims and Timely Assertion of Claims
    4.6.5
Claims for Additional Cost
    3.2.3, 4.3.4, 4.3.5, 4.3.6, 6.1.1, 7.3.8, 10.3.2
Claims for Additional Time

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue,
N.W. Washington, D.C. 20006-5292

                                                                               2

<PAGE>

    3.2.3, 4.3.4, 4.3.7, 6.1.1, 8.3.2, 10.3.2
Claims for Concealed or Unknown Conditions
    4.3.4
Claims for Damages
    3.2.3, 3.18, 4.3.10, 6.1.1, 8.3.3, 9.5.1, 9.6.7, 10.3.3, 11.1.1, 11.4.5,
    11.4.7, 11.1.3, 14,2,4
Claims Subject to Arbitration
    4.4.1, 4.5.1, 4.6.1
Cleaning Up
    3.15, 6.3
Commencement of Statutory Limitation Period
    13.7
Commencement of the Work, Conditions Relating to
    2.2.1, 3.2.1, 3.4.1, 3.7.1, 3.10.1, 3.12.6, 4.3.5, 5.2.1, 5.2.3, 6.2.2,
    8.1.2, 8.2.2, 8.3.1, 11.1, 11.4.1, 11.4.6, 11.5.1
Commencement of the Work, Definition of
    8.1.2
Communications Facilitating Contract Administration
    3.9.1, 4.2.4
Completion, Conditions Relating to
    1.6.1, 3.4.1, 3.11, 3.15, 4.2.2, 4.2.9, 8.2, 9.4.2, 9.8, 9.9.1, 9.10, 12.2,
    13.7, 14.1.2
COMPLETION, PAYMENTS AND
    9
Completion, Substantial
    4.2.9, 8.1.1, 8.1.3, 8.2.3, 9.4.2, 9.8, 9.9.1, 9.10.3, 9.10.4.2, 12.2, 13.7
Compliance with Laws
    1.6.1, 3.2.2, 3.6, 3.7, 3.12.10, 3.13, 4.1.1, 4.4.8, 4.6.4, 4.6.6, 9.6.4,
    10.2.2, 11.1, 11.4, 13.1, 13.4, 13.5.1, 13.5.2, 13.6, 14.1.1, 14.2.1.3
Concealed or Unknown Conditions
    4.3.4, 8.3.1, 10.3
Conditions of the Contract
    1.1.1, 1.1.7, 6.1.1, 6.1.4
Consent, Written
    1.6, 3.4.2, 3.12.8, 3.14.2, 4.1.2, 4.3.4, 4.6.4, 9.3.2, 9.8.5, 9.9.1,
    9.10.2, 9.10.3, 11.4.1, 13.2, 13.4.2
CONSTRUCTION BY OWNER OR BY SEPARATE CONTRACTORS
    1.1.4, 6
Construction Change Directive, Definition of
    7.3.1
Construction Change Directives
    1.1.1, 3.12.8, 4.2.8, 4.3.9, 7.1, 7.3, 9.3.1.1
Construction Schedules, Contractor's
    1.4.1.2, 3.10, 3.12.1, 3.12.2, 4.3.7.2, 6.1.3
Contingent Assignment of Subcontracts
    5.4, 14.2.2.2
Continuing Contract Performance
    4.3.3
Contract, Definition of
    1.1.2
CONTRACT TERMINATION OR SUSPENSION OF THE
    5.4.1.1, 11.4.9, 14
Contract Administration
    3.1.3, 4, 9.4, 9.5
Contract Award and Execution, Conditions Relating to
    3.7.1, 3.10, 5.2, 6.1, 11.1.3, 11.4.6, 11.5.1
Contract Documents, The
    1.1, 1.2
Contract Documents, Copies Furnished and Use of
    1.6, 2.2.5, 5.3
Contract Documents, Definition of
    1.1.1
Contract Sum
    3.8, 4.3.4, 4.3.5, 4.4.5, 5.2.3, 7.2, 7.3, 7.4, 9.1, 9.4.2, 9.5.1.4, 9.6.7,
    9.7, 10.3.2, 11.4.1, 14.2.4, 14.3.2
Contract Sum, Definition of
    9.1
Contract Time
    4.3.4, 4.3.7, 4.4.5, 5.2.3, 7.2.1.3, 7.3, 7.4, 8.1.1, 8.2, 8.3.1, 9.5.1,
    9.7, 10.3.2, 12.1.1, 14.3.2
Contract Time, Definition of
    8.1.1
CONTRACTOR
    3
Contractor, Definition of
    3.1, 6.1.2
Contractor's Construction Schedules
    1.4.1.2, 3.10, 3.12.1, 3.12.2, 4.3.7.2, 6.1.3
Contractor's Employees
    3.3.2, 3.4.3, 3.8.1, 3.9, 3.18.2, 4.2.3, 4.2.6, 10.2, 10.3, 11.1.1, 11.4.7,
    14.1, 14.2.1.1,
Contractor's Liability Insurance
    11.1
Contractor's Relationship with Separate Contractors and Owner's Forces
    3.12.5, 3.14.2, 4.2.4, 6, 11.4.7, 12.1.2, 12.2.4
Contractor's Relationship with Subcontractors
    1.2.2, 3.3.2, 3.18.1, 3.18.2, 5, 9.6.2, 9.6.7, 9.10.2, 11.4.1.2, 11.4.7,
    11.4.8
Contractor's Relationship with the Architect
    1.1.2, 1.6, 3.1.3, 3.2.1, 3.2.2, 3.2.3, 3.3.1, 3.4.2, 3.5.1, 3.7.3, 3.10,
    3.11, 3.12, 3.16, 3.18, 4.1.2, 4.1.3, 4.2, 4.3.4, 4.4.1, 4.4.7, 5.2, 6.2.2,
    7, 8.3.1, 9.2, 9.3, 9.4, 9.5, 9.7, 9.8, 9.9, 10.2.6, 10.3, 11.3, 12, 13.4.2,
    13.5
Contractor's Representations
    1.5.2, 3.5.1, 3.12.6, 6.2.2, 8.2.1, 9.3.3, 9.8.2
Contractor s Responsibility for Those Performing the Work
    3.3.2, 3.18, 4.2.3, 4.3.8, 5.3.1, 6.1.3, 6.2, 6.3, 9.5.1, 10

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               3

<PAGE>

Contractor's Review of Contract Documents
    1.5.2, 3.2, 3.7.3
Contractor's Right to Stop the Work
    9.7
Contractor's Right to Terminate the Contract
    4.3.10, 14.1
Contractor's Submittals
    3.10, 3.11, 3.12, 4.2.7, 5.2.1, 5.2.3, 7.3.6, 9.2, 9.3, 9.8.2, 9.8.3, 9.9.1,
    9.10.2, 9.10.3, 11.1.3, 11.5.2
Contractor's Superintendent
    3.9, 10.2.6
Contractor's Supervision and Construction Procedures
    1.2.2, 3.3, 3.4, 3.12.10, 4.2.2, 4.2.7, 4.3.3, 6.1.3, 6.2.4, 7.1.3, 7.3.4,
    7.3.6, 8.2, 10, 12, 14
Contractual Liability Insurance
    11.1.1.8, 11.2, 11.3
Coordination and Correlation
    1.2, 1.5.2, 3.3.1, 3.10, 3.12.6, 6.1.3, 6.2.1
Copies Furnished of Drawings and Specifications
    1.6, 2.2.5, 3.11
Copyrights
    1.6, 3.17
Correction of Work
    2.3, 2.4, 3.7.4, 4.2.1, 9.4.2, 9.8.2, 9.8.3, 9.9.1, 12.1.2, 12.2, 13.7.1.3
Correlation and Intent of the Contract Documents
    1.2
Cost, Definition of
    7.3.6
Costs
    2.4, 3.2.3, 3.7.4, 3.8.2, 3.15.2, 4.3, 5.4.2, 6.1.1, 6.2.3, 7.3.3.3, 7.3.6,
    7.3.7, 7.3.8, 9.10.2, 10.3.2, 10.5, 11.3, 11.4, 12.1, 12.2.1, 12.2.4, 13.5,
    14
Cutting and Patching
    6.2.5, 3.14
Damage to Construction of Owner or Separate Contractors
    3.14.2, 6.2.4, 9.2.1.5, 10.2.1.2, 10.2.5, 10.6, 11.1, 11.4, 12.2.4
Damage to the Work
    3.14.2, 9.9.1, 10.2.1.2, 10.2.5, 10.6, 11.4, 12.2.4
Damages, Claims for
    3.2.3, 3.18, 4.3.10, 6.1.1, 8.3.3, 9.5.1, 9.6.7, 10.3.3, 11.1.1, 11.4.5,
    11.4.7, 14.1.3, 14.2.4
Damages for Delay
    6.1.1, 8.3.3, 9.5.1.6, 9.7, 10.3.2
Date of Commencement of the Work, Definition of
    8.1.2
Date of Substantial Completion, Definition of
    8.1.3
Day, Definition of
    8.1.4
Decisions of the Architect
    4.2.6, 4.2.7, 4.2.11, 4.2.12, 4.2.13, 4.3.4, 4.4.1, 4.4.5, 4.4.6, 4.5, 6.3,
    7.3.6, 7.3.8, 8.1.3, 8.3.1, 9.2, 9.4, 9.5.1, 9.84, 9.9.1, 13.5.2, 14.2.2,
    14.2.4
Decisions to Withhold Certification
    9.4.1, 9.5, 9.7, 14.1.1.3
Defective or Nonconforming Work, Acceptance, Rejection and Correction of
    2.3, 2.4, 3.5.1, 4.2.6, 6.2.5, 9.5.1, 9.5.2, 9.6.6, 9.8.2, 9.9.3, 9.10.4,
    12.2.1, 13.7.1.3
Defective Work, Definition of
    3.5.1
Definitions
    1.1, 2.1.1, 3.1, 3.5.1, 3.12.1, 3.12.2, 3.12.3, 4.1.1, 4.3.1, 5.1, 6.1.2,
    7.2.1, 7.3.1, 7.3.6, 8.1, 9.1, 9.8.1
Delays and Extensions of Time
    3.2.3, 4.3.1, 4.3.4, 4.3.7, 4.4.5, 5.2.3, 7.2.1, 7.3.1, 7.4.1, 7.5.1, 8.3,
    9.5.1, 9.7.1, 10.3.2, 10.6.1, 14.3.2
Disputes
    4.1.4, 4.3, 4.4, 4.5, 4.6, 6.3, 7.3.8
Documents and Samples at the Site
    3.11
Drawings, Definition of
    1.1.5
Drawings and Specifications, Use and Ownership of
    1.1.1, 1.3, 2.2.5, 3.11, 5.3
Effective Date of Insurance
    8.2.2, 11.1.2
Emergencies
    4.3.5, 10.6, 14.1.1.2
Employees, Contractor's
    3.3.2, 3.4.3, 3.8.1, 3.9, 3.18.2, 4.2.3, 4.2.6, 10.2, 10.3, 11.1.1, 11.4.7,
    14.1, 14.2.1
Equipment, Labor, Materials and
    1.1.3, 1.1.6, 3.4, 3.5.1, 3.8.2, 3.8.3, 3.12, 3.13, 3.15.1, 4.2.6, 4.2.7,
    5.2.1, 6.2.1, 7.3.6, 9.3.2, 9.3.3, 9.5.1.3, 9.10.2, 10.2.1, 10.2.4, 14.2.1.2
Execution and Progress of the Work
    1.1.3, 1.2.1, 1.2.2, 2.2.3, 2.2.5, 3.1, 3.3, 3.4, 3.5, 3.7, 3.10, 3.12,
    3.14, 4.2.2, 4.2.3, 4.3.3, 6.2.2, 7.1.3, 7.3.4, 8.2, 9.5, 9.9.1, 10.2, 10.3,
    12.2, 14.2, 14.3
Extensions of Time
    3.2.3, 4.3.1, 4.3.4, 4.3.7, 4.4.5, 5.2.3, 7.2.1, 7.3, 7.4.1, 9.5.1, 9.7.1,
    10.3.2, 10.6.1, 14.3.2
Failure of Payment
    4.3.6, 9.5.1.3, 9.7, 9.10.2, 14.1.1.3, 14.2.1.2, 13.6
Faulty Work
    (See Defective or Nonconforming Work)
Final Completion and Final Payment
    4.2.1, 4.2.9, 4.3.2, 9.8.2, 9.10, 11.1.2, 11.1.3, 11.4.1, 11.4.5, 12.3.1,
    13.7, 14.2.4, 14.4.3
Financial Arrangements, Owner's
    2.2.1, 13.2.2, 14.1.1.5
Fire and Extended Coverage Insurance
    11.4
GENERAL PROVISIONS

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION Of
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               4

<PAGE>

    1
Governing Law
    13.1
Guarantees (See Warranty)
Hazardous Materials
    10.2.4, 10.3, 10.5
Identification of Contract Documents
    1.5.1
Identification of Subcontractors and Suppliers
    5.2.1
Indemnification
    3.17, 3.18, 9.10.2, 10.3.3, 10.5, 11.4.1.2, 11.4.7
Information and Services Required of the Owner
    2.1.2, 2.2, 3.2.1, 3.12.4, 3.12.10, 4.2.7, 4.3.3, 6.1.3, 6.1.4, 6.2.5,
    9.3.2, 9.6.1, 9.6.4, 9.9.2, 9.10.3, 10.3.3, 11.2, 11.4, 13.5.1, 13.5.2,
    14.1.1.4, 14.1.4

Injury or Damage to Person or Property
    4.3.8, 10.2, 10.6
Inspections
    3.1.3, 3.3.3, 3.7.1, 4.2.2, 4.2.6, 4.2.9, 9.4.2, 9.8.2, 9.8.3, 9.9.2,
    9.10.1, 12.2.1, 13.5
Instructions to Bidders
    1.1.1
Instructions to the Contractor
    3.2.3, 3.3.1, 3.8.1, 4.2.8, 5.2.1, 7, 12, 8.2.2, 13.5.2
Insurance
    3.18.1, 6.1.1, 7.3.6, 8.2.1, 9.3.2, 9.8.4, 9.9.1, 9.10.2, 9.10.5, 11
Insurance, Boiler and Machinery
    11.4.2
Insurance, Contractor's Liability
     11.1
Insurance, Effective Date of
    8.2.2, 11.1.2
Insurance, Loss of Use
    11.4.3
Insurance, Owner's Liability
    11.2
Insurance, Project Management Protective Liability
    11.3
Insurance, Property
    10.2.5, 11.4
Insurance, Stored Materials
    9.3.2, 11.4.1.4
INSURANCE AND BONDS
    11
Insurance Companies, Consent to Partial Occupancy
    9.9.1, 11.4.1.5
Insurance Companies, Settlement with
    11.4.10
Intent of the Contract Documents
    1.2.1, 4.2.7, 4.2.12, 4.2.13, 7.4
Interest
    13.6
Interpretation
    1.2.3, 1.4, 4.1.1, 4.3.1, 5.1, 6.1.2, 8.1.4
Interpretations, Written
    4.2.11, 4.2.12, 4.3.6
Joinder and Consolidation of Claims Required
    4.6.4
Judgment on Final Award
    4.6.6
Labor and Materials, Equipment
    1.1.3, 1.1.6, 3.4, 3.5.1, 3.8.2, 3.8.3, 3.12, 3.13, 3.15.1, 42.6, 4.2.7,
    5.2.1, 6.2.1, 7.3.6, 9.3.2, 9.3.3, 9.5.1.3, 9.10.2, 10.2.1, 10.2.4, 14.2.1.2
Labor Disputes
    8.3.1
Laws and Regulations
    1.6, 3.2.2, 3.6, 3.7, 3.12.10, 3.13, 4.1.1, 4.4.8, 4.6, 9.6.4, 9.9.1,
    10.2.2, 11.1, 11.4, 13.1, 13.4, 13.5.1, 13.5.2, 13.6, 14
Liens
    2.1.2, 4.4.8, 8.2.2, 9.3.3, 9.10
Limitation on Consolidation or Joinder
    4.6.4
Limitations, Statutes of
    4.6.3, 12.2.6, 13.7
Limitations of Liability
    2.3, 3.2.1, 3.5.1, 3.7.3, 3.12.8, 3.12.10, 3.17, 3.18, 4.2.6, 4.2.7, 4.2.12,
    6.2.2, 9.4.2, 9.6.4, 9.6.7, 9.10.4, 16.3.3, 10.2.5, 11.1.2, 11.2.1, 11.4.7,
    12.2.5, 13.4.2
Limitations of Time
    2.1.2, 2.2, 2.4, 3.2.1, 3.7.3, 3.10, 3.11, 3.12.5, 3.15.1, 4.2.7, 4.3, 4.4,
    4.5, 4.6, 5.2, 5.3, 5.4, 6.2.4, 7.3, 7.4, 8.2, 9.2, 9.3.1, 9.3.3, 9.4.1,
    9.5, 9.6, 9.7, 9.8, 9.9, 9.10, 11.1.3, 11.4.1.5, 11.4.6, 11.4.10, 12.2,
    13.5, 13.7, 14
Loss of Use Insurance
    11.4.3
Material Suppliers
    1.6, 3.12.1, 4.2.4, 4.2.6, 5.2.1, 9.3, 9.4.2, 9.6, 9.10.5
Materials, Hazardous
    10.2.4, 10.3, 10.5
Materials, Labor, Equipment and
    1.1.3, 1.1.6, 1.6.1, 3.4, 3.5.1, 3.8.2, 3.8.23, 3.12, 3.13, 3.15.1, 4.2.6,
    4.2.7, 5.2.1, 6.2.1, 7.3.6, 9.3.2, 9.3.3, 9.5.1.3, 9.10.2, 10.24, 10.2.4,
    14.2.1.2
Means, Methods, Techniques, Sequences and Procedures of Construction
    3.3.1, 3.12.10, 4.2.2, 4.2.7, 9.4.2
Mechanic's Lien
    4.4.8
Mediation
    4.4.1, 4.4.5, 44.6, 4.4.8, 4.5, 4.6.1, 4.6.2, 8.3.1, 10.5
Minor Changes in the Work

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT 0401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue. N.W.
Washington, D.C. 20006-5292

                                                                               5

<PAGE>

    1.1.1, 3.12.8, 4.2.8, 4.3.6, 7.1, 7.4
MISCELLANEOUS PROVISIONS
    13
Modifications, Definition of
    1.1.1
Modifications to the Contract
    1.1.1, 1.1.2, 3.7.3, 3.11, 4.1.2, 4.2.1, 5.2.3, 7, 8.3.1, 9.7, 10.3.2,
    11.4.1
Mutual Responsibility
    6.2
Nonconforming Work, Acceptance of
    9.6.6, 9.9.3, 12.3
Nonconforming Work, Rejection and Correction of
    2.3, 2.4, 3.5.1, 4.2.6, 6.2.5, 9.5.1, 9.8.2, 9.9.3, 9.10.4, 12.2.1, 13.7.1.3
Notice
    2.2.1, 2.3, 2.4, 3.2.3, 3.3.1, 3.7.2, 3.7.4, 3.12.9, 4.3, 4.4.8, 4.6.5,
    5.2.1, 8.2.2, 9.7, 9.10, 10.2.2, 11.1.3, 11.4.6, 12.2.2, 12.2.4, 13.3,
    13.5.1, 13.5.2, 14.1, 14.2
Notice, Written
    2.3, 2.4, 3.3.1, 3.9, 3.12.9, 3.12.10, 4.3, 4.4.8, 4.6.5, 5.2.1, 8.2.2, 9.7,
    9.10, 10.2.2, 10.3, 11.1.3, 11.4.6, 12.2.2, 12.2.4, 13.3, 14
Notice of Testing and Inspections
    13.5.1, 13.5.2
Notice to Proceed
    8.2.2
Notices, Permits, Fees and
    2.2.2, 3.7, 3.13,7.3.6.4, 10.2.2
Observations, Contractor's
    1.5.2, 3.2, 3.7.3, 4.3.4
Occupancy
    2.2.2, 9.6.6, 9.8, 11.4.1.5
Orders, Written
    1.1.1, 2.3, 3.9, 4.3.6, 7, 8.2.2, 11.4.9, 12.1, 12.2, 13.5.2, 14.3.1
OWNER
    2
Owner, Definition of
    2.1
Owner, Information and Services Required of the
    2.1.2, 2.2, 3.2.1, 3.12.4, 3.12.10, 4.2.7, 4.3.3, 6.1.3, 6.1.4, 6.2.5,
    9.3.2, 9.6.1, 9.6.4, 9.9.2, 9.10.3, 10.3.3, 11.2, 11.4, 13.5.1, 13.5.2,
    14.1.1.4, 14.1.4
Owner's Authority
    1.6, 2.1.1, 2.3, 2.4, 3.4.2, 3.8.1, 3.12.10, 3.14.2, 4.1.2, 4.1.3, 4.2.4,
    4.2.9, 4.3.6, 4.4.7, 5.2.1, 5.2.4, 5.4.1, 6.1, 6.3, 7.2.1, 7.3.1, 8.2.2,
    8.3.1, 9.3.1, 9.3.2, 9.5.1, 9.9.1, 9.10.2, 10.3.2, 11.1.3, 11.3.1, 11.4.3,
    11.4.10, 12.2.2, 12.3.1, 13.2.2, 14.3, 14.4
Owner's Financial Capability
    2.2.1, 13.2.2, 14.1.1.5
Owner's Liability Insurance
    11.2
Owner's Loss of Use Insurance
    11.4.3
Owner's Relationship with Subcontractors
    1.1.2, 5.2, 5.3, 5.4, 9.6.4, 9.10.2, 14.2.2
Owner's Right to Carry Out the Work
    2.4, 12.2.4, 14.2.2.2
Owner's Right to Clean Up
    6.3
Owner's Right to Perform Construction and to Award Separate Contracts
    6.1
Owner's Right to Stop the Work
    2.3
Owner's Right to Suspend the Work
    14.3
Owner's Right to Terminate the Contract
    14.2
Ownership and Use of Drawings, Specifications and Other Instruments of Service
    1.1.1, 1.6, 2.2.5, 3.2.1, 3.11.1, 3.17.1, 4.2.12, 5.3
Partial Occupancy or Use
    9.6.6, 9.9, 11.4.1.5
Patching, Cutting and
    3.14,6.2.5
Patents
    3.17
Payment, Applications for
    4.2.5, 7.3.8, 9.2, 9.3, 9.4, 9.5.1, 9.6.3, 9.7.1, 9.8.5, 9.10.1, 9.10.3,
    9.10.5, 11.1.3, 14.2.4, 14.4.3
Payment, Certificates for
    4.2.5, 4.2.9, 9.3.3, 9.4, 9.5, 9.6.1, 9.6.6, 9.7.1, 9.10.1, 9.10.3, 13.7,
    14.1.1.3, 14.2.4
Payment, Failure of
    4.3.6, 9.5.1.3, 9.7, 9.10.2, 14.1.1.3, 14.2.1.2, 13.6
Payment, Final
    4.2.1, 4.2.9, 4.3.2, 9.8.2, 9.10, 11.1.2, 11.1.3, 11.4.1, 11.4.5, 12.3.1,
    13.7, 14.2.4, 14.4.3
Payment Bond, Performance Bond and
    7.3.6.4, 9.6.7, 9.10.3, 11.4.9, 11.5
Payments, Progress
    4.3.3, 9.3, 9.6, 9.8.5, 9.10.3, 13.6, 14.2.3
PAYMENTS AND COMPLETION
    9
Payments to Subcontractors
    5.4.2, 9.5.1.3, 9.6.2, 9.6.3, 9.6.4, 9.6.7, 11.4.8, 14.2.1.2
PCB
    10.3.1
Performance Bond and Payment Bond
    7.3.6.4, 9.6.7, 9.10.3, 11.4.9, 11.5
Permits, Fees and Notices
    2.2.2, 3.7, 3.13, 7.3.6.4, 10.2.2
PERSONS AND PROPERTY, PROTECTION

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THB DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               6

<PAGE>

OF
     10
Polychlorinated Biphenyl
    10.3.1
Product Data, Definition of
    3.12.2
Product Data and Samples, Shop Drawings
    3.11,3.12,4.2.7
Progress and Completion
    4.2.2, 4.3.3, 8.2, 9.8, 9.9.1, 14.1.4
Progress Payments
    4.3.3, 9.3, 9.6, 9.8.5, 9.10.3, 13.6, 14.2.3
Project, Definition of the
    1.1.4
Project Management Protective Liability Insurance
    11.3
Project Manual, Definition of the
    1.1.7
Project Manuals
    2.2.5
Project Representatives
    4.2.10
Property Insurance
    10.2.5,11.4
PROTECTION OF PERSONS AND PROPERTY
    10
Regulations and Laws
    1.6, 3.2.2, 3.6, 3.7, 3.12.10, 3.13, 4.1.1, 4.4.8, 4.6, 9.6.4, 9.9.1,
    10.2.2, 11.1, 11.4, 13.1, 13.4, 13.5.1, 13.5.2,13.6,14
Rejection of Work
    3.5.1, 4.2.6, 12.2.1
Releases and Waivers of Liens
    9.10.2
Representations
    1.5.2, 3.5.1, 3.12.6, 6.2.2, 8.2.1, 9.3.3, 9.4.2, 9.5.1, 9.8.2, 9.10.1
Representatives
    2.1.1, 3.1.1, 3.9, 4.1.1, 4.2.1, 4.2.10, 5.1.1, 5.1.2, 13.2.1
Resolution of Claims and Disputes
    4.4, 4.5, 4.6
Responsibility for Those Performing the Work
    3.3.2, 3.18, 4.2.3, 4.3.8, 5.3.1, 6.1.3, 6.2, 6.3, 9.5.1, 10
Retainage
    9.3.1, 9.6.2, 9.8.5, 9.9.1, 9.10.2, 9.10.3
Review of Contract Documents and Field Conditions by Contractor
    1.5.2, 3.2, 3.7.3, 3.12.7, 6.1.3
Review of Contractor's Submittals by Owner and Architect
    3.10.1, 3.10.2, 3.11, 3.12, 4.2, 5.2, 6.1.3, 9.2, 9.8.2
Review of Shop Drawings, Product Data and Samples by Contractor
    3.12
Rights and Remedies
    1.1.2, 2.3, 2.4, 3.5.1, 3.15.2, 4.2.6, 4.3.4, 4.5, 4.6, 5.3, 5.4, 6.1, 6.3,
    7.3.1, 8.3, 9.5.1, 9.7, 10.2.5, 10.3, 12.2.2, 12.2.4, 13.4,14
Royalties, Patents and Copyrights
    3.17
Rules and Notices for Arbitration
    4.6.2
Safety of Persons and Properly
    10.2, 10.6
Safely Precautions and Programs
    3.3.1, 4.2.2, 4.2.7, 5.3.1, 10.1, 10.2, 10.6
Samples, Definition of
    3.12.3
Samples, Shop Drawings, Product Data and
    3.11, 3.12, 4.2.7
Samples at the Site, Documents and
    3.11
Schedule of Values
    9.2, 9.3.1
Schedules, Construction
    1.4.1.2, 3.10, 3.12.1, 3.12.2, 4.3.7.2, 6.1.3
Separate Contracts and Contractors
    1.1.4, 3.12.5, 3.14.2, 4.2.4, 4.2.7, 4.6.4, 6, 8.3.1, 11.4.7, 12.1.2, 12.2.5
Shop Drawings, Definition of
    3.12.1
Shop Drawings, Product Data and Samples
    3.11, 3.12, 4.2.7
Site, Use of
    3.13, 6.1.1, 6.2.1
Site Inspections
    1.2.2, 3.2.1, 3.3.3, 3.7.1, 4.2, 4.3.4, 9.4.2, 9.10.1, 13.5
Site Visits, Architect's
    4.2.2, 4.2.9, 4.3.4, 9.4.2, 9.5.1, 9.9.2, 9.10.1, 13.5
Special Inspections and Testing
    4.2.6, 12.2.1, 13.5
Specifications, Definition of the
    1.1.6
Specifications, The
    1.1.1, 1.1.6, 1.1.7, 1.2.2, 1.6, 3.11, 3.12.10, 3.17
Statute of Limitations
    4.6.3, 12.2.6, 13.7
Stopping the Work
    2.3, 4.3.6, 9.7, 10.3, 14.1
Stored Materials
    6.2.1, 9.3.2, 10.2.1.2, 10.2.4, 11.4.1.4
Subcontractor, Definition of
    5.1.1
SUBCONTRACTORS
    5

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington. D.C. 20006-5292

                                                                               7

<PAGE>

Subcontractors, Work by
    1.2.2, 3.3.2, 3.12.1, 4.2.3, 5.2.3, 5.3, 5.4, 9.3.1.2, 9.6.7
Subcontractual Relations
    5.3, 5.4, 9.3.1.2, 9.6, 9.10, 10.2.1, 11.4.7, 11.4.8, 14.1, 14.2.1, 14.3.2
Submittals
    1.6, 3.10, 3.11, 3.12, 4.2.7, 5.2.1, 5.2.3, 7.3.6, 9.2, 9.3, 9.8, 9.9.1,
    9.10.2, 9.10.3, 11.1.3
Subrogation, Waivers of
    6.1.1, 11.4.5, 11.4.7
Substantial Completion
    4.2.9, 8.1.1, 8.1.3, 8.2.3, 9.4.2, 9.8, 9.9.1, 9.10.3, 9.10.4.2, 12.2, 13.7
Substantial Completion, Definition of
    9.8.1
Substitution of Subcontractors
    5.2.3, 5.2.4
Substitution of Architect
    4.1.3
Substitutions of Materials
    3.4.2, 3.5.1, 7.3. 7
Sub-subcontractor, Definition of
    5.1.2
Subsurface Conditions
    4.3.4
Successors and Assigns
    13.2
Superintendent
    3.9, 10.2.6
Supervision and Construction Procedures
    1.2.2, 3.3, 3.4, 3.12.10, 4.2.2, 4.2.7, 4.3.3, 6.1.3, 6.2.4, 7.1.3, 7.3.6,
    8.2, 8.3.1, 9.4.2, 10, 12, 14
Surety
    4.4.7, 5.4.1.2, 9.8.5, 9.10.2, 9.10.3, 14.2.2
Surety, Consent of
    9.10.2, 9.10.3
Surveys
    2.2.3
Suspension by the Owner for Convenience
    14.4
Suspension of the Work
    5.4.2, 14.3
Suspension or Termination of the Contract
    4.3.6, 5.4.1.1, 11.4.9, 14
Taxes
    3.6, 3.8.2.1, 7.3.6.4
Termination by the Contractor
    4.3.10, 14.1
Termination by the Owner for Cause
    4.3.10, 5.4.1.1, 14.2
Termination of the Architect
    4.1.3
Termination of the Contractor
    14.2.2
TERMINATION OR SUSPENSION OF THE CONTRACT
    14
Tests and Inspections
    3.1.3, 3.3.3, 4.2.2, 4.2.6, 4.2.9, 9.4.2, 9.8.3, 9.9.2, 9.1O.1, 1O.3.2,
    11.4.1.1, 12.2.1, 13.5
TIME
    8
Time, Delays and Extensions of
    3.2.3, 4.3.1, 4.3.4, 4.3.7, 4.4.5, 5.2.3, 7.2.1, 7.3.1, 7.4.1, 7.5.1, 8.3,
    9.5.1, 9.7.1, 10.3.2, 10.6.1, 14.3.2
Time Limits
    2.1.2, 2.2, 2.4, 3.2.1, 3.7.3, 3.10, 3.11, 3.12.5, 3.15.1, 4.2, 4.3, 4.4,
    4.5, 4.6, 5.2, 5.3, 5.4, 6.2.4, 7.3, 7.4, 8.2, 9.2, 9.3.1, 9.3.3, 94.1, 9.5,
    9.6, 9.7, 9.8, 9.9, 9.10, 11.1.3, 11.4.1.5, 11.4.6, 11.4.10, 12.2, 13.5,
    13.7, 14
Time Limits on Claims
    4.3.2, 4.3.4, 4.3.8, 4.4, 4.5, 4.6
Title to Work
    9.3.2, 9.3.3
UNCOVERING AND CORRECTION OF WORK
    12
Uncovering of Work
    12.1
Unforeseen Conditions
    4.3.4, 8.3.1, 10.3
Unit Prices
    4.3.9, 7.3.3.2
Use of Documents
    1.1.1, 1.6, 2.2.5, 3.12.6, 5.3
Use of Site
    3.13, 6.1.1, 6.2.1
Values, Schedule of
    9.2, 9.3.1
Waiver of Claims by the Architect
    13.4.2
Waiver of Claims by the Contractor
    4.3.10, 9.10.5, 11.4.7, 13.4.2
Waiver of Claims by the Owner
    4.3.10, 9.9.3, 9.10.3, 9.10.4, 11.4.3, 11.4.5, 11.4.7, 12.2.2.1, 13.4.2,
    14.2.4
Waiver of Consequential Damages
    4.3.10, 14.2.4
Waiver of Liens
    9.10.2, 9.10.4
Waivers of Subrogation
    6.1.1, 11.4.5, 11.4.7
Warranty
    3.5, 4.2.9, 4.3.5.3, 9.3.3, 9.8.4, 9.9.1, 9.10.4, 12.2.2,13.7.1.3
Weather Delays
    4.3.7.2

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
197O, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C) 1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               8

<PAGE>

Work, Definition of
    1.1.3
Written Consent
    1.6, 3.4.2, 3.12.8, 3.14.2, 4.1.2, 4.3.4, 4.6.4, 9.3.2, 9.8.5, 9.9.1,
    9.10.2, 9.10.3, 11.4.1, 13.2, 13.4.2
Written Interpretations
    4.2.11, 4.2.12, 4.3.6
Written Notice
    2.3, 2.4, 3.3.1, 3.9, 3.12.9, 3.12.10, 4.3, 4.4.8, 4.6.5, 5.2.1, 8.2.2, 9.7,
    9.10, 10.2.2, 10.3, 11.1.3, 11.4.6, 12.2.2, 12.2.4, 13.3, 14
Written Orders
    11.1, 2.3, 3.9, 4.3.6, 7, 8.2.2, 11.4.9, 12.1, 12.2, 13.5.2, 14.3.1

ARTICLE 1 GENERAL PROVISIONS

         1.1 BASIC DEFINITIONS

         1.1.1 THE CONTRACT DOCUMENTS

         The Contract Documents consist of the Agreement between Owner and
         Contractor (hereinafter the Agreement), Conditions of the Contract
         (General, Supplementary and other Conditions), Drawings,
         Specifications, Addenda issued prior to execution of the Contract,
         other documents listed in the Agreement and Modifications issued after
         execution of the Contract. A Modification is (i) a written amendment to
         the Contract signed by both parties, (2) a Change Order, (3) a
         Construction Change Directive or (4) a written order for a minor change
         in the Work issued by the Architect. Unless specifically enumerated in
         the Agreement, the Contract Documents do not include other documents
         such as bidding requirements (advertisement or invitation to bid,
         Instructions to Bidders, sample forms, the Contractor's bid or portions
         of Addenda relating to bidding requirements).

         1.1.2 THE CONTRACT

         The Contract Documents form the Contract for Construction. The Contract
         represents the entire and integrated agreement between the parties
         hereto and supersedes prior negotiations, representations or
         agreements, either written or oral. The Contract may be amended or
         modified only by a Modification. The Contract Documents shall not be
         construed to create a contractual relationship of any kind (i) between
         the Architect and Contractor, (2) between the Owner and a Subcontractor
         or Sub-subcontractor, (3) between the Owner and Architect or (4)
         between any persons or entities other than the Owner and Contractor.
         The Architect shall, however, be entitled to performance and
         enforcement of obligations under the Contract intended to facilitate
         performance of the Architect's duties.

         1.1.3 THE WORK

         The term "Work" means the construction and services required by the
         Contract Documents, whether completed or partially completed, and
         includes all other labor, materials, equipment and services provided or
         to be provided by the Contractor to fulfill the Contractor's
         obligations. The Work may constitute the whole or a part of the
         Project.

         1.1.4 THE PROJECT

         The Project is the total construction of which the Work performed under
         the Contract Documents may be the whole or a part and which may include
         construction by the Owner or by separate contractors.

         1.1.5 THE DRAWINGS

         The Drawings are the graphic and pictorial portions of the Contract
         Documents showing the design, location and dimensions of the Work,
         generally including plans, elevations, sections, details, schedules and
         diagrams.

         1.1.6 THE SPECIFICATIONS

---------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia - 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

(C) 1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                               9
<PAGE>

         The Specifications are that portion of the Contract Documents
         consisting of the written requirements for materials, equipment,
         systems, standards and workmanship for the Work, and performance of
         related services.

         1.1.7    THE PROJECT MANUAL

         The Project Manual is a volume assembled for the Work which may include
         the bidding requirements, sample forms, Conditions of the Contract and
         Specifications.

         1.2      CORRELATION AND INTENT OF THE CONTRACT DOCUMENTS

         1.2.1    The intent of the Contract Documents is to include all items
         necessary for the proper execution and completion of the Work by the
         Contractor. The Contract Documents are complementary, and what is
         required by one shall be as binding as if required by all; performance
         by the Contractor shall be required only to the extent consistent with
         the Contract Documents and reasonably inferable from them as being
         necessary to produce the indicated results.

         1.2.2    Organization of the Specifications into divisions, sections
         and articles, and arrangement of Drawings shall not control the
         Contractor in dividing the Work among Subcontractors or in establishing
         the extent of Work to be performed by any trade.

         1.2.3    Unless otherwise stated in the Contract Documents, words which
         have well-known technical or construction industry meanings are used in
         the Contract Documents in accordance with such recognized meanings.

         1.3      CAPITALIZATION

         1.3.1    Terms capitalized in these General Conditions include those
         which are (i) specifically defined, (2) the titles of numbered articles
         and identified references to Paragraphs, Subparagraphs and Clauses in
         the document or (3) the titles of other documents published by the
         American Institute of Architects.

         1.4      INTERPRETATION

         1.4.1    In the interest of brevity the Contract Documents frequently
         omit modifying words such as "all" and "any" and articles such as "the"
         and "an," but the fact that a modifier or an article is absent from one
         statement and appears in another is not intended to affect the
         interpretation of either statement.

         1.5      EXECUTION OF CONTRACT DOCUMENTS

         1.5.1    The Contract Documents shall be signed by the Owner and
         Contractor. If either the Owner or Contractor or both do not sign all
         the Contract Documents, the Architect shall identify such unsigned
         Documents upon request.

         1.5.2    Execution of the Contract by the Contractor is a
         representation that the Contractor has visited the site, become
         generally familiar with local conditions under which the Work is to be
         performed and correlated personal observations with requirements of the
         Contract Documents.

         1.6      OWNERSHIP AND USE OF DRAWINGS, SPECIFICATIONS AND OTHER
                  INSTRUMENTS OF SERVICE

         1.6.1    The Drawings, Specifications and other documents, including
         those in electronic form, prepared by the Architect and the Architect's
         consultants are Instruments of Service through which the Work to be
         executed by the Contractor is described. The Contractor may retain one
         record set. Neither the Contractor nor any Subcontractor,
         Sub-subcontractor or material or equipment supplier shall own or claim
         a copyright in the Drawings, Specifications and other documents
         prepared by the Architect or the Architect's consultants, and unless
         otherwise indicated the Architect and the Architect's consultants shall
         be deemed the authors of

-------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA - 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

THIS DOCUMENT HAS BEEN APPROVED AND ENDORSED BY THE ASSOCIATED GENERAL
CONTRACTORS OF AMERICA.

[LOGO]

(C)997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              10

<PAGE>

         them and will retain all common law, statutory and other reserved
         rights, in addition to the copyrights. All copies of Instruments of
         Service, except the Contractor's, Subcontractors, and suppliers record
         sets, shall be returned or suitably accounted for to the Architect, on
         request, upon completion of the Work. The Drawings, Specifications and
         other documents prepared by the Architect and the Architect's
         consultants, and copies thereof furnished to the Contractor, are for
         use solely with respect to this Project. They are not to be used by the
         Contractor or any Subcontractor, Sub-subcontractor or material or
         equipment supplier on other projects or for additions to this Project
         outside the scope of the Work without the specific written consent of
         the Owner, Architect and the Architect's consultants. The Contractor,
         Subcontractors, Sub-subcontractors and material or equipment suppliers
         are authorized to use and reproduce applicable portions of the
         Drawings, Specifications and other documents prepared by the Architect
         and the Architect's consultants appropriate to and for use in the
         execution of their Work under the Contract Documents. All copies made
         under this authorization shall bear the statutory copyright notice, if
         any, shown on the Drawings, Specifications and other documents prepared
         by the Architect and the Architect's consultants. Submittal or
         distribution to meet official regulatory requirements or for other
         purposes in connection with this Project is not to be construed as
         publication in derogation of the Architect's or Architect's
         consultants' copyrights or other reserved rights.

ARTICLE 2 OWNER

         2.1      GENERAL

         2.1.1    The Owner is the person or entity identified as such in the
         Agreement and is referred to throughout the Contract Documents as if
         singular in number. The Owner shall designate in writing a
         representative who shall have express authority to bind the Owner with
         respect to all matters requiring the Owner's approval or authorization.
         Except as otherwise provided in Subparagraph 4.2.1, the Architect does
         not have such authority. The term "Owner" means the Owner or the
         Owner's authorized representative.

         2.1.2    The Owner shall furnish to the Contractor within fifteen days
         after receipt of a written request, information necessary and relevant
         for the Contractor to evaluate, give notice of or enforce mechanic's
         lien rights. Such information shall include a correct statement of the
         record legal title to the property on which the Project is located,
         usually referred to as the site, and the Owner's interest therein.

         2.2      INFORMATION AND SERVICES REQUIRED OF THE OWNER

         2.2.1    The Owner shall, at the written request of the Contractor,
         prior to commencement of the Work and thereafter, furnish to the
         Contractor reasonable evidence that financial arrangements have been
         made to fulfill the Owner's obligations under the Contract. Furnishing
         of such evidence shall be a condition precedent to commencement or
         continuation of the Work. After such evidence has been furnished, the
         Owner shall not materially vary such financial arrangements without
         prior notice to the Contractor.

         2.2.2    Except for permits and fees, including those required under
         Subparagraph 3.7.1, which are the responsibility of the Contractor
         under the Contract Documents, the Owner shall secure and pay for
         necessary approvals, easements, assessments and charges required for
         construction, use or occupancy of permanent structures or for permanent
         changes in existing facilities.

         2.2.3    The Owner shall furnish surveys describing physical
         characteristics, legal limitations and utility locations for the site
         of the Project, and a legal description of the site. The Contractor
         shall be entitled to rely on the accuracy of information furnished by
         the Owner but shall exercise proper precautions relating to the safe
         performance of the Work.

         2.2.4    Information or services required of the Owner by the Contract
         Documents shall be furnished by the Owner with reasonable promptness.
         Any other information or services relevant to the Contractor's
         performance of the Work under the Owner's control shall be

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW. EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              11

<PAGE>

         furnished by the Owner after receipt from the Contractor of a written
         request for such information or services.

         2.2.5    Unless otherwise provided in the Contract Documents, the
         Contractor will be furnished, free of charge, such copies of Drawings
         and Project Manuals as are reasonably necessary for execution of the
         Work.

         2.3      OWNER'S RIGHT TO STOP THE WORK

         2.3.1    If the Contractor fails to correct Work which is not in
         accordance with the requirements of the Contract Documents as required
         by Paragraph 12.2 or persistently fails to carry out Work in accordance
         with the Contract Documents, the Owner may issue a written order to the
         Contractor to stop the Work, or any portion thereof, until the cause
         for such order has been eliminated; however, the right of the Owner to
         stop the Work shall not give rise to a duty on the part of the Owner to
         exercise this right for the benefit of the Contractor or any other
         person or entity, except to the extent required by Subparagraph 6.1.3.

         2.4      OWNER'S RIGHT TO CARRY OUT THE WORK

         2.4.1    If the Contractor defaults or neglects to carry out the Work
         in accordance with the Contract Documents and fails within a seven-day
         period after receipt of written notice from the Owner to commence and
         continue correction of such default or neglect with diligence and
         promptness, the Owner may after such seven-day period give the
         Contractor a second written notice to correct such deficiencies within
         a three-day period. If the Contractor within such three-day period
         after receipt of such second notice fails to commence and continue to
         correct any deficiencies, the Owner may, without prejudice to other
         remedies the Owner may have, correct such deficiencies. In such case an
         appropriate Change Order shall be issued deducting from payments then
         or thereafter due the Contractor the reasonable cost of correcting such
         deficiencies, including Owner's expenses and compensation for the
         Architect's additional services made necessary by such default, neglect
         or failure. Such action by the Owner and amounts charged to the
         Contractor are both subject to prior approval of the Architect. If
         payments then or thereafter due the Contractor are not sufficient to
         cover such amounts, the Contractor shall pay the difference to the
         Owner.

ARTICLE 3 CONTRACTOR

         3.1      GENERAL

         3.1.1    The Contractor is the person or entity identified as such in
         the Agreement and is referred to throughout the Contract Documents as
         if singular in number. The term "Contractor" means the Contractor or
         the Contractor's authorized representative.

         3.1.2    The Contractor shall perform the Work in accordance with the
         Contract Documents.

         3.1.3    The Contractor shall not be relieved of obligations to perform
         the Work in accordance with the Contract Documents either by activities
         or duties of the Architect in the Architect's administration of the
         Contract, or by tests, inspections or approvals required or performed
         by persons other than the Contractor.

         3.2      REVIEW OF CONTRACT DOCUMENTS AND FIELD CONDITIONS BY
                  CONTRACTOR

         3.2.1    Since the Contract Documents are complementary, before
         starting each portion of the Work, the Contractor shall carefully study
         and compare the various Drawings and other Contract Documents relative
         to that portion of the Work, as well as the information furnished by
         the Owner pursuant to Subparagraph 2.2.3, shall take field measurements
         of any existing conditions related to that portion of the Work and
         shall observe any conditions at the site affecting it. These
         obligations are for the purpose of facilitating construction by the
         Contractor and are not for the purpose of discovering errors,
         omissions, or inconsistencies in the Contract Documents; however, any
         errors, inconsistencies or omissions discovered by the Contractor

--------------------------------------------------------------------------------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below. Expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004.
AIA License Number 1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              12

<PAGE>

         shall be reported promptly to the Architect as a request for
         information in such form as the Architect may require.

         3.2.2    Any design errors or omissions noted by the Contractor during
         this review shall be reported promptly to the Architect, but it is
         recognized that the Contractor's review is made in the Contractor's
         capacity as a contractor and not as a licensed design professional
         unless otherwise specifically provided in the Contract Documents. The
         Contractor is not required to ascertain that the Contract Documents are
         in accordance with applicable laws, statutes, ordinances, building
         codes, and rules and regulations, but any nonconformity discovered by
         or made known to the Contractor shall be reported promptly to the
         Architect.

         3.2.3    If the Contractor believes that additional cost or time is
         involved because of clarifications or instructions issued by the
         Architect in response to the Contractor's notices or requests for
         information pursuant to Subparagraphs 3.2.1 and 3.2.2, the Contractor
         shall make Claims as provided in Subparagraphs 4.3.6 and 4.3.7. If the
         Contractor fails to perform the obligations of Subparagraphs 3.2.1 and
         3.2.2, the Contractor shall pay such costs and damages to the Owner as
         would have been avoided if the Contractor had performed such
         obligations. The Contractor shall not be liable to the Owner or
         Architect for damages resulting from errors, inconsistencies or
         omissions in the Contract Documents or for differences between field
         measurements or conditions and the Contract Documents unless the
         Contractor recognized such error, inconsistency, omission or difference
         and knowingly failed to report it to the Architect.

         3.3      SUPERVISION AND CONSTRUCTION PROCEDURES

         3.3.1    The Contractor shall supervise and direct the Work, using the
         Contractor's best skill and attention. The Contractor shall be solely
         responsible for and have control over construction means, methods,
         techniques, sequences and procedures and for coordinating all portions
         of the Work under the Contract, unless the Contract Documents give
         other specific instructions concerning these matters. If the Contract
         Documents give specific instructions concerning construction means,
         methods, techniques, sequences or procedures, the Contractor shall
         evaluate the jobsite safety thereof and, except as stated below, shall
         be fully and solely responsible for the jobsite safety of such means,
         methods, techniques, sequences or procedures. If the Contractor
         determines that such means, methods, techniques, sequences or
         procedures may not be safe, the Contractor shall give timely written
         notice to the Owner and Architect and shall not proceed with that
         portion of the Work without further written instructions from the
         Architect. If the Contractor is then instructed to proceed with the
         required means, methods, techniques, sequences or procedures without
         acceptance of changes proposed by the Contractor, the Owner shall be
         solely responsible for any resulting loss or damage.

         3.3.2    The Contractor shall be responsible to the Owner for acts and
         omissions of the Contractor's employees, Subcontractors and their
         agents and employees, and other persons or entities performing portions
         of the Work for or on behalf of the Contractor or any of its
         Subcontractors.

         3.3.3    The Contractor shall be responsible for inspection of portions
         of Work already performed to determine that such portions are in proper
         condition to receive subsequent Work.

         3.4      LABOR AND MATERIALS

         3.4.1    Unless otherwise provided in the Contract Documents, the
         Contractor shall provide and pay for labor, materials, equipment,
         tools, construction equipment and machinery, water, heat, utilities,
         transportation, and other facilities and services necessary for proper
         execution and completion of the Work, whether temporary or permanent
         and whether or not incorporated or to be incorporated in the Work.

         3.4.2    The Contractor may make substitutions only with the consent of
         the Owner, after evaluation by the Architect and in accordance with a
         Change Order.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              13

<PAGE>

         3.4.3    The Contractor shall enforce strict discipline and good order
         among the Contractor's employees and other persons carrying out the
         Work The Contractor shall not permit employment of unfit persons or
         persons not skilled in tasks assigned to them.

         3.5      WARRANTY

         3.5.1    The Contractor warrants to the Owner and Architect that
         materials and equipment furnished under the Contract will be of good
         quality and new unless otherwise required or permitted by the Contract
         Documents, that the Work will be free from defects not inherent in the
         quality required or permitted, and that the Work will conform to the
         requirements of the Contract Documents. Work not conforming to these
         requirements, including substitutions not properly approved and
         authorized, may be considered defective. The Contractor's warranty
         excludes remedy for damage or defect caused by abuse, modifications not
         executed by the Contractor, improper or insufficient maintenance,
         improper operation, or normal wear and tear under normal usage. If
         required by the Architect, the Contractor shall furnish satisfactory
         evidence as to the kind and quality of materials and equipment.

         3.6      TAXES

         3.6.1    The Contractor shall pay sales, consumer, use and similar
         taxes for the Work provided by the Contractor which are legally enacted
         when bids are received or negotiations concluded, whether or not yet
         effective or merely scheduled to go into effect.

         3.7      PERMITS, FEES AND NOTICES

         3.7.1    Unless otherwise provided in the Contract Documents, the
         Contractor shall secure and pay for the building permit and other
         permits and governmental fees, licenses and inspections necessary for
         proper execution and completion of the Work which are customarily
         secured after execution of the Contract and which are legally required
         when bids are received or negotiations concluded.

         3.7.2    The Contractor shall comply with and give notices required by
         laws, ordinances, rules, regulations and lawful orders of public
         authorities applicable to performance of the Work.

         3.7.3    It is not the Contractor's responsibility to ascertain that
         the Contract Documents are in accordance with applicable laws,
         statutes, ordinances, building codes, and rules and regulations.
         However, if the Contractor observes that portions of the Contract
         Documents are at variance therewith, the Contractor shall promptly
         notify the Architect and Owner in writing, and necessary changes shall
         be accomplished by appropriate Modification.

         3.7.4    If the Contractor performs Work knowing it to be contrary to
         laws, statutes, ordinances, building codes, and rules and regulations
         without such notice to the Architect and Owner, the Contractor shall
         assume appropriate responsibility for such Work and shall bear the
         costs attributable to correction.

         3.8      ALLOWANCES

         3.8.1    The Contractor shall include in the Contract Sum all
         allowances stated in the Contract Documents. Items covered by
         allowances shall be supplied for such amounts and by such persons or
         entities as the Owner may direct, but the Contractor shall not be
         required to employ persons or entities to whom the Contractor has
         reasonable objection.

         3.8.2    Unless otherwise provided in the Contract Documents:

                  .1       allowances shall cover the cost to the Contractor of
                           materials and equipment delivered at the site and all
                           required taxes, less applicable trade discounts;

--------------------------------------------------------------------------------
(C)COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958. 1961, 1963, 1966. 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845. WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

THIS DOCUMENT HAS BEEN APPROVED AND ENDORSED BY THE ASSOCIATED GENERAL
CONTRACTORS OF AMERICA.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 -1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington. D.C. 20006-5292

                                                                              14
<PAGE>

                  .2       Contractor's costs for unloading and handling at the
                           site, labor, installation costs, overhead, profit and
                           other expenses contemplated for stated allowance
                           amounts shall be included in the allowances;

                  .3       whenever costs are more than or less than allowances,
                           the Contract Sum shall be adjusted accordingly by
                           Change Order. The amount of the Change Order shall
                           reflect (1) the difference between actual costs and
                           the allowances under Clause 3.8.2.1 and Clause
                           3.8.2.2.

         3.8.3    Materials and equipment under an allowance shall be selected
         by the Owner in sufficient time to avoid delay in the Work.

         3.9      SUPERINTENDENT

         3.9.1    The Contractor shall employ a competent superintendent and
         necessary assistants who shall be in attendance at the Project site
         during performance of the Work. The superintendent shall represent the
         Contractor, and communications given to the superintendent shall be as
         binding as if given to the Contractor. Important communications shall
         be confirmed in writing. Other communications shall be similarly
         confirmed on written request in each case.

         3.10     CONTRACTOR'S CONSTRUCTION SCHEDULES

         3.10.1   The Contractor, promptly after being awarded the Contract,
         shall prepare and submit for the Owner's and Architect's information a
         Contractor's construction schedule for the Work. The schedule shall not
         exceed time limits current under the Contract Documents, shall be
         revised at appropriate intervals as required by the conditions of the
         Work and Project, shall be related to the entire Project to the extent
         required by the Contract Documents, and shall provide for expeditious
         and practicable execution of the Work.

         3.10.2   The Contractor shall prepare and keep current, for the
         Architect's approval, a schedule of submittals which is coordinated
         with the Contractor's construction schedule and allows the Architect
         reasonable time to review submittals.

         3.10.3   The Contractor shall perform the Work in general accordance
         with the most recent schedules submitted to the Owner and Architect.

         3.11     DOCUMENTS AND SAMPLES AT THE SITE

         3.11.1   The Contractor shall maintain at the site for the Owner one
         record copy of the Drawings, Specifications, Addenda, Change Orders and
         other Modifications, in good order and marked currently to record field
         changes and selections made during construction, and one record copy of
         approved Shop Drawings, Product Data, Samples and similar required
         submittals. These shall be available to the Architect and shall be
         delivered to the Architect for submittal to the Owner upon completion
         of the Work.

         3.12     SHOP DRAWINGS, PRODUCT DATA AND SAMPLES

         3.12.1   Shop Drawings are drawings, diagrams, schedules and other data
         specially prepared for the Work by the Contractor or a Subcontractor,
         Sub-subcontractor, manufacturer, supplier or distributor to illustrate
         some portion of the Work.

         3.12.2   Product Data are illustrations, standard schedules,
         performance charts, instructions, brochures, diagrams and other
         information furnished by the Contractor to illustrate materials or
         equipment for some portion of the Work.

         3.12.3   Samples are physical examples which illustrate materials,
         equipment or workmanship and establish standards by which the Work will
         be judged.

(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              15
<PAGE>

         3.12.4   Shop Drawings, Product Data, Samples and similar submittals
         are not Contract Documents. The purpose of their submittal is to
         demonstrate for those portions of the Work for which submittals are
         required by the Contract Documents the way by which the Contractor
         proposes to conform to the information given and the design concept
         expressed in the Contract Documents. Review by the Architect is subject
         to the limitations of Subparagraph 4.2.7. Informational submittals upon
         which the Architect is not expected to take responsive action may be so
         identified in the Contract Documents. Submittals which are not required
         by the Contract Documents may be returned by the Architect without
         action.

         3.12.5   The Contractor shall review for compliance with the Contract
         Documents, review to ensure conformance and submit to the Architect
         Shop Drawings, Product Data, Samples and similar submittals required by
         the Contract Documents with reasonable promptness and in such sequence
         as to cause no delay in the Work or in the activities of the Owner or
         of separate contractors. Submittals which are not marked as reviewed
         for compliance with the Contract Documents and approved by the
         Contractor may be returned by the Architect without action.

         3.12.6   By review and verification of consistancy with project
         requirements, submitting Shop Drawings, Product Data, Samples and
         similar submittals, the Contractor represents that the Contractor has
         determined and verified materials, field measurements and field
         construction criteria related thereto, or will do so, and has checked
         and coordinated the information contained within such submittals with
         the requirements of the Work and of the Contract Documents.

         3.12.7   The Contractor shall perform no portion of the Work for which
         the Contract Documents require submittal and review of Shop Drawings,
         Product Data, Samples or similar submittals until the respective
         submittal has been approved by the Architect.

         3.12.8   The Work shall be in accordance with approved submittals
         except that the Contractor shall not be relieved of responsibility for
         deviations from requirements of the Contract Documents by the
         Architect's approval of Shop Drawings, Product Data, Samples or similar
         submittals unless the Contractor has specifically informed the
         Architect in writing of such deviation at the time of submittal and (1)
         the Architect has given written approval to the specific deviation as a
         minor change in the Work, or (2) a Change Order or Construction Change
         Directive has been issued authorizing the deviation. The Contractor
         shall not be relieved of responsibility for errors or omissions in Shop
         Drawings, Product Data, Samples or similar submittals by the
         Architect's approval thereof.

         3.12.9   The Contractor shall direct specific attention, in writing or
         on resubmitted Shop Drawings, Product Data, Samples or similar
         submittals, to revisions other than those requested by the Architect on
         previous submittals. In the absence of such written notice the
         Architect's approval of a resubmission shall not apply to such
         revisions.

         3.12.10  The Contractor shall not be required to provide professional
         services which constitute the practice of architecture or engineering
         unless such services are specifically required by the Contract
         Documents for a portion of the Work or unless the Contractor needs to
         provide such services in order to carry out the Contractor's
         responsibilities for construction means, methods, techniques, sequences
         and procedures. The Contractor shall not be required to provide
         professional services in violation of applicable law. If professional
         design services or certifications by a design professional related to
         systems, materials or equipment are specifically required of the
         Contractor by the Contract Documents, the Owner and the Architect will
         specify all performance and design criteria that such services must
         satisfy. The Contractor shall cause such services or certifications to
         be provided by a properly licensed design professional, whose signature
         and seal shall appear on all drawings, calculations, specifications,
         certifications, Shop Drawings and other submittals prepared by such
         professional. Shop Drawings and other submittals related to the Work
         designed or certified by such professional, if prepared by others,

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              16
<PAGE>

         shall bear such professional's written approval when submitted to the
         Architect. The Owner and the Architect shall be entitled to rely upon
         the adequacy, accuracy and completeness of the services, certifications
         or approvals performed by such design professionals, provided the Owner
         and Architect have specified to the Contractor all performance and
         design criteria that such services must satisfy. Pursuant to this
         Subparagraph 3.12.10, the Architect will review, approve or take other
         appropriate action on submittals only for the limited purpose of
         checking for conformance with information given and the design concept
         expressed in the Contract Documents. The Contractor shall not be
         responsible for the adequacy of the performance or design criteria
         required by the Contract Documents.

         3.13     USE OF SITE

         3.13.1   The Contractor shall confine operations at the site to areas
         permitted by law, ordinances, permits and the Contract Documents and
         shall not unreasonably encumber the site with materials or equipment.

         3.14     CUTTING AND PATCHING

         3.14.1   The Contractor shall be responsible for cutting, fitting or
         patching required to complete the Work or to make its parts fit
         together properly.

         3.14.2   The Contractor shall not damage or endanger a portion of the
         Work or fully or partially completed construction of the Owner or
         separate contractors by cutting, patching or otherwise altering such
         construction, or by excavation. The Contractor shall not cut or
         otherwise alter such construction by the Owner or a separate contractor
         except with written consent of the Owner and of such separate
         contractor, such consent shall not be unreasonably withheld. The
         Contractor shall not unreasonably withhold from the Owner or a separate
         contractor the Contractor's consent to cutting or otherwise altering
         the Work.

         3.15     CLEANING UP

         3.15.1   The Contractor shall keep the premises and surrounding area
         free from accumulation of waste materials or rubbish caused by
         operations under the Contract. At completion of the Work, the
         Contractor shall remove from and about the Project waste materials,
         rubbish, the Contractor's tools, construction equipment, machinery and
         surplus materials.

         3.15.2   If the Contractor fails to clean up as provided in the
         Contract Documents, the Owner may do so and the cost thereof shall be
         charged to the Contractor.

         3.16     ACCESS TO WORK

         3.16.1   The Contractor shall provide the Owner and Architect access to
         the Work in preparation and progress wherever located.

         3.17     ROYALTIES, PATENTS AND COPYRIGHTS

         3.17.1   The Contractor shall pay all royalties and license fees. The
         Contractor shall defend suits or claims for infringement of copyrights
         and patent rights and shall hold the Owner and Architect harmless from
         loss on account thereof, but shall not be responsible for such defense
         or loss when a particular design, process or product of a particular
         manufacturer or manufacturers is required by the Contract Documents or
         where the copyright violations are contained in Drawings,
         Specifications or other documents prepared by the Owner or Architect.
         However, if the Contractor has reason to believe that the required
         design, process or product is an infringement of a copyright or a
         patent, the Contractor shall be responsible for such loss unless such
         information is promptly furnished to the Architect.

         3.18     INDEMNIFICATION

         3.18.1   To the fullest extent permitted by law, the Contractor shall
         indemnify and hold

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute Of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              17

<PAGE>

         harmless the Owner, Architect, Architect's consultants, and agents and
         employees of any of them from and against claims, damages, losses and
         expenses, including but not limited to attorneys' fees, arising out of
         or resulting from performance of the Work, provided that such claim,
         damage, loss or expense is attributable to bodily injury, sickness,
         disease or death, or to injury to or destruction of tangible property
         (other than the Work itself), but only to the extent caused by the
         negligent acts or omissions of the Contractor, a Subcontractor, anyone
         directly or indirectly employed by them or anyone for whose acts they
         may be liable, regardless of whether or not such claim, damage, loss or
         expense is caused in part by a party indemnified hereunder. Such
         obligation shall not be construed to negate, abridge, or reduce other
         rights or obligations of indemnity which would otherwise exist as to a
         party or person described in this Paragraph 3.18.

         3.18.2   In claims against any person or entity indemnified under this
         Paragraph 3.18 by an employee of the Contractor, a Subcontractor,
         anyone directly or indirectly employed by them or anyone for whose acts
         they may be liable, the indemnification obligation under Subparagraph
         3.18.1 shall not be limited by a limitation on amount or type of
         damages, compensation or benefits payable by or for the Contractor or a
         Subcontractor under workers' compensation acts, disability benefit acts
         or other employee benefit acts.

ARTICLE 4 ADMINISTRATION OF THE CONTRACT

         4.1      ARCHITECT

         4.1.1    The Architect is the person lawfully licensed to practice
         architecture or an entity lawfully practicing architecture identified
         as such in the Agreement and is referred to throughout the Contract
         Documents as if singular in number. The term "Architect" means the
         Architect or the Architect's authorized representative.

         4.1.2    Duties, responsibilities and limitations of authority of the
         Architect as set forth in the Contract Documents shall not be
         restricted, modified or extended without written consent of the Owner,
         Contractor and Architect. Consent shall not be unreasonably withheld.

         4.1.3    If the employment of the Architect is terminated, the Owner
         shall employ a new Architect against whom the Contractor has no
         reasonable objection and whose status under the Contract Documents
         shall be that of the former Architect.

         4.2      ARCHITECT'S ADMINISTRATION OF THE CONTRACT

         4.2.1    The Architect will have authority to act on behalf of the
         Owner only to the extent provided in the Contract Documents, unless
         otherwise modified in writing in accordance with other provisions of
         the Contract.

         4.2.2    The Architect, will visit the site at intervals appropriate
         to the stage of the Contractor's operations (1) to become generally
         familiar with and to keep the Owner informed about the progress and
         quality of the portion of the Work completed, (2) to endeavor to guard
         the Owner against defects and deficiencies in the Work, and (3) to
         determine in general if the Work is being performed in a manner
         indicating that the Work, when fully completed, will be in accordance
         with the Contract Documents. However, the Architect will not be
         required to make exhaustive or continuous on-site inspections to check
         the quality or quantity of the Work. The Architect will neither have
         control over or charge of, nor be responsible for, the construction
         means, methods, techniques, sequences or procedures, or for the safety
         precautions and programs in connection with the Work, since these are
         solely the Contractor's rights and responsibilities under the Contract
         Documents, except as provided in Subparagraph 3.3.1.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              18

<PAGE>

         4.2.3    The Architect will not be responsible for the Contractor's
         failure to perform the Work in accordance with the requirements of the
         Contract Documents. The Architect will not have control over or charge
         of and will not be responsible for acts or omissions of the Contractor,
         Subcontractors, or their agents or employees, or any other persons or
         entities performing portions of the Work.

         4.2.4    Communications by and with the Architect's consultants shall
         be through the Architect. Communications by and with Subcontractors and
         material suppliers shall be through the Contractor. Communications by
         and with separate contractors shall be through the Owner.

         4.2.5    Based on the Architect's evaluations of the Contractor's
         Applications for Payment, the Architect will review and certify the
         amounts due the Contractor and will issue Certificates for Payment in
         such amounts.

         4.2.6    The Architect will have authority to reject Work that does not
         conform to the Contract Documents. Whenever the Architect considers it
         necessary or advisable, the Architect will have authority to require
         inspection or testing of the Work in accordance with Subparagraphs
         13.5.2 and 13.5.3, whether or not such Work is fabricated, installed or
         completed. However, neither this authority of the Architect nor a
         decision made in good faith either to exercise or not to exercise such
         authority shall give rise to a duty or responsibility of the Architect
         to the Contractor, Subcontractors, material and equipment suppliers,
         their agents or employees, or other persons or entities performing
         portions of the Work.

         4.2.7    The Architect will review and approve or take other
         appropriate action upon the Contractor's submittals such as Shop
         Drawings, Product Data and Samples, but only for the limited purpose of
         checking for conformance with information given and the design concept
         expressed in the Contract Documents. The Architect's action will be
         taken with such reasonable promptness as to cause no delay in the Work
         or in the activities of the Owner, Contractor or separate contractors,
         while allowing sufficient time in the Architect's professional judgment
         to permit adequate review. Review of such submittals is not conducted
         for the purpose of determining the accuracy and completeness of other
         details such as dimensions and quantities, or for substantiating
         instructions for installation or performance of equipment or systems,
         all of which remain the responsibility of the Contractor as required by
         the Contract Documents. The Architect's review of the Contractor's
         submittals shall not relieve the Contractor of the obligations under
         Paragraphs 3.3, 3.5 and 3.12. The Architect's review shall not
         constitute approval of safety precautions or, unless otherwise
         specifically stated by the Architect, of any construction means,
         methods, techniques, sequences or procedures. The Architect's approval
         of a specific item shall not indicate approval of an assembly of which
         the item is a component.

         4.2.8    The Architect will prepare Change Orders and Construction
         Change Directives, and may authorize minor changes in the Work as
         provided in Paragraph 7.4.

         4.2.9    The Architect will conduct inspections to determine the date
         or dates of Substantial Completion and the date of final completion,
         will receive and forward to the Owner, for the Owner's review and
         records, written warranties and related documents required by the
         Contract and assembled by the Contractor, and will issue a final
         Certificate for Payment upon compliance with the requirements of the
         Contract Documents.

         4.2.10   If the Owner and Architect agree, the Architect will provide
         one or more project representatives to assist in carrying out the
         Architect's responsibilities at the site. The duties, responsibilities
         and limitations of authority of such project representatives shall be
         as set forth in an exhibit to be incorporated in the Contract
         Documents.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              19

<PAGE>

         4.2.11   The Architect will interpret and decide matters concerning
         performance under and requirements of, the Contract Documents on
         written request of either the Owner or Contractor. The Architect's
         response to such requests will be made in writing within any time
         limits agreed upon or otherwise with reasonable promptness. If no
         agreement is made concerning the time within which interpretations
         required of the Architect shall be furnished in compliance with this
         Paragraph 4.2, then delay shall not be recognized on account of failure
         by the Architect to furnish such interpretations until 15 days after
         written request is made for them.

         4.2.12   Interpretations and decisions of the Architect will be
         consistent with the intent of and reasonably inferable from the
         Contract Documents and will be in writing or in the form of drawings.
         When making such interpretations and initial decisions, the Architect
         will endeavor to secure faithful performance by both Owner and
         Contractor, will not show partiality to either and will not be liable
         for results of interpretations or decisions so rendered in good faith.

         4.2.13   The Architect's decisions on matters relating to aesthetic
         effect will be final if consistent with the intent expressed in the
         Contract Documents.

         4.3      CLAIMS AND DISPUTES

         4.3.1    DEFINITION. A Claim is a demand or assertion by one of the
         parties seeking, as a matter of right, adjustment or interpretation of
         Contract terms, payment of money, extension of time or other relief
         with respect to the terms of the Contract. The term "Claim" also
         includes other disputes and matters in question between the Owner and
         Contractor arising out of or relating to the Contract. Claims must be
         initiated by written notice. The responsibility to substantiate Claims
         shall rest with the party making the Claim.

         4.3.2    TIME LIMITS ON CLAIMS. Claims by either party must be
         initiated within 21 days after occurrence of the event giving rise to
         such Claim or within 21 days after the claimant first recognizes the
         condition giving rise to the Claim, whichever is later. Claims must be
         initiated by written notice to the Architect and the other party.

         4.3.3    CONTINUING CONTRACT PERFORMANCE. PENDING final resolution of a
         Claim except as otherwise agreed in writing or as provided in
         Subparagraph 9.7.1 and Article 14, the Contractor shall proceed
         diligently with performance of the Contract and the Owner shall
         continue to make payments in accordance with the Contract Documents.

         4.3.4    CLAIMS FOR CONCEALED OR UNKNOWN CONDITIONS. If conditions are
         encountered at the site which are (1) subsurface or otherwise concealed
         physical conditions which differ materially from those indicated in the
         Contract Documents or (2) unknown physical conditions of an unusual
         nature, which differ materially from those ordinarily found to exist
         and generally recognized as inherent in construction activities of the
         character provided for in the Contract Documents, then notice by the
         observing party shall be given to the other party promptly before
         conditions are disturbed and in no event later than 21 days after first
         observance of the conditions. The Architect will promptly investigate
         such conditions and, if they differ materially and cause an increase or
         decrease in the Contractor's cost of, or time required for, performance
         of any part of the Work, will recommend an equitable adjustment in the
         Contract Sum or Contract Time, or both. If the Architect determines
         that the conditions at the site are not materially different from those
         indicated in the Contract Documents and that no change in the terms of
         the Contract is justified, the Architect shall so notify the Owner and
         Contractor in writing, stating the reasons. Claims by either party in
         opposition to such determination must be made within 21 days after the
         Architect has given notice of the decision. If the conditions
         encountered are materially different, the Contract Sum and Contract
         Time shall be equitably adjusted, but if the Owner and Contractor
         cannot agree on an adjustment in the Contract Sum or Contract Time, the
         adjustment shall be subject to further proceedings pursuant to
         Paragraph 4.4.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              20

<PAGE>

         4.3.5    CLAIMS FOR ADDITIONAL COST. If the Contractor wishes to make
         Claim for an increase in the Contract Sum, written notice as provided
         herein shall be given before proceeding to execute the Work. Prior
         notice is not required for Claims relating to an emergency endangering
         life or property arising under Paragraph 10.6.

         4.3.6    If the Contractor believes additional cost is involved for
         reasons including but not limited to (1) a written interpretation from
         the Architect, (2) an order by the Owner to stop the Work where the
         Contractor was not at fault, (3) a written order for a minor change in
         the Work issued by the Architect, (4) failure of payment by the Owner,
         (5) termination of the Contract by the Owner, (6) Owner's suspension or
         (7) other reasonable grounds, Claim shall be filed in accordance with
         this Paragraph 4.3.

         4.3.7    CLAIMS FOR ADDITIONAL TIME

         4.3.7.1  If the Contractor wishes to make Claim for an increase in the
         Contract Time, written notice as provided herein shall be given. The
         Contractor's Claim shall include an estimate of cost and of probable
         effect of delay on progress of the Work. In the case of a continuing
         delay only one Claim is necessary.

         4.3.7.2  If adverse weather conditions are the basis for a Claim for
         additional time, such Claim shall be documented by data substantiating
         that weather conditions were abnormal for the period of time, could not
         have been reasonably anticipated and had an adverse effect on the
         scheduled construction.

         4.3.8    INJURY OR DAMAGE TO PERSON OR PROPERTY. If either party to the
         Contract suffers injury or damage to person or property because of an
         act or omission of the other party, or of others for whose acts such
         party is legally responsible, written notice of such injury or damage,
         whether or not insured, shall be given to the other party within a
         reasonable time not exceeding 21 days after discovery. The notice shall
         provide sufficient detail to enable the other party to investigate the
         matter.

         4.3.9    If unit prices are stated in the Contract Documents or
         subsequently agreed upon, and if quantities originally contemplated are
         materially changed in a proposed Change Order or Construction Change
         Directive so that application of such unit prices to quantities of Work
         proposed will cause substantial inequity to the Owner or Contractor,
         the applicable unit prices shall be equitably adjusted.

         4.3.10   CLAIMS FOR CONSEQUENTIAL DAMAGES. The Contractor and Owner
         waive Claims against each other for consequential damages arising out
         of or relating to this Contract. This mutual waiver includes:

                  .1       damages incurred by the Owner for rental expenses,
                           for losses of use, income, profit, financing,
                           business and reputation, and for loss of management
                           or employee productivity or of the services of such
                           persons; and

                  .2       damages incurred by the Contractor for principal
                           office expenses including the compensation of
                           personnel stationed there, for losses of financing,
                           business and reputation, and for loss of profit
                           except anticipated profit arising directly from the
                           Work.

         This mutual waiver is applicable, without limitation, to all
         consequential damages due to either party's termination in accordance
         with Article 14. Nothing contained in this Subparagraph 4.3.10 shall be
         deemed to preclude an award of liquidated direct damages, when
         applicable, in accordance with the requirements of the Contract
         Documents.

         4.4      INITIAL RESOLUTION OF CLAIMS AND DISPUTES

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              21

<PAGE>

         4.4.1    If a Claim arises out of or relates to the Contract or its
         breach, the parties shall endeavor to settle the Claim initially
         through direct negotiation of the parties' Representatives, who shall
         have authority to settle the Claim. If the parties fail to settle the
         Claim promptly, the parties' senior executives, who shall have the
         authority to settle the Claim, shall meet within 21 days after the
         Claim first arises. If the Claim is not settled within the next seven
         days, the parties shall submit the Claim to mediation in accordance
         with Paragraph 4.5.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              22
<PAGE>

         4.4.2    If a Claim relates to or is the subject of a mechanic's lien,
         the party asserting such Claim may proceed in accordance with
         applicable law to comply with the lien notice or filing deadlines prior
         to resolution of the Claim by the Architect, by mediation or by
         arbitration. The Contractor shall bond over any mechanic's lien
         arising hereunder within five days notice of the filing thereof.

         4.5      MEDIATION

         4.5.1    If the parties fail to settle the Claim pursuant to Paragraph
         4.4, any Claim arising out of or related to the Contract, except Claims
         relating to aesthetic effect and except those waived as provided for in
         Subparagraphs 4.3.10, 9.10.4 and 9.10.5, shall within 30 days after
         failure to settle the Claim pursuant to Paragraph 4.4 be subject to
         mediation as a condition precedent to arbitration.

         4.5.2    The parties shall endeavor to resolve their Claims by
         mediation which shall be in accordance with the Construction Industry
         Mediation Rules of the American Arbitration Association currently in
         effect. Request for mediation shall be filed in writing with the other
         party to the Contract and with the American Arbitration Association.
         The request may be made concurrently with the filing of a demand for
         arbitration but, in such event, mediation shall proceed in advance of
         arbitration which shall be stayed pending mediation for a period of 30
         days from the date of filing, unless stayed for a longer period by
         agreement of the parties.

         4.5.3    The parties shall share the mediator's fee and any filing fees
         equally. The mediation shall be held in the place where the Project is
         located, unless another location is mutually agreed upon. Agreements
         reached in mediation shall be enforceable as settlement agreements in
         any court having jurisdiction thereof.

         4.6      ARBITRATION

         4.6.1.   Claims not resolved by mediation shall be decided by
         arbitration which shall be in accordance with the Construction Industry
         Arbitration Rules of the American Arbitration Association currently in
         effect. The demand for arbitration shall be filed in writing with the
         other party to the Contract and with the American Arbitration
         Association, and a copy shall be filed with the Architect.

         4.6.2    A demand for arbitration shall be made within thirty days
         after failure of the Claim to be settled pursuant to Paragraph 4.5 and
         in no event shall it be made after the date when institution of legal
         or equitable proceedings based on such Claim would be barred by the
         applicable statute of limitations as determined pursuant to Paragraph
         13.7.

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              23
<PAGE>

         4.6.3    CLAIMS AND TIMELY ASSERTION OF CLAIMS. The party filing a
         notice of demand for arbitration must assert in the demand all Claims
         then known to that party on which arbitration is permitted to be
         demanded.

         4.6.4    JUDGMENT ON FINAL AWARD. The award rendered by the arbitrator
         or arbitrators shall be final, and judgment may be entered upon it in
         accordance with applicable law in any court having jurisdiction
         thereof.

ARTICLE 5 SUBCONTRACTORS

         5.1      DEFINITIONS

         5.1.1    A Subcontractor is a person or entity who has a direct
         contract with the Contractor to perform a portion of the Work at the
         site. The term "Subcontractor" is referred to throughout the Contract
         Documents as if singular in number and means a Subcontractor or an
         authorized representative of the Subcontractor. The term
         "Subcontractor" does not include a separate contractor or
         subcontractors of a separate contractor.

         5.1.2    A Sub-subcontractor is a person or entity who has a direct or
         indirect contract with a Subcontractor to perform a portion of the Work
         at the site. The term "Sub-subcontractor" is referred to throughout the
         Contract Documents as if singular in number and means a Sub-
         subcontractor or an authorized representative of the Sub-subcontractor.

         5.2      AWARD OF SUBCONTRACTS AND OTHER CONTRACTS FOR PORTIONS OF THE
                  WORK

         5.2.1    Unless otherwise stated in the Contract Documents or the
         bidding requirements, the Contractor, as soon as practicable after
         award of the Contract, shall furnish in writing to the Owner through
         the Architect the names of persons or entities (including those who are
         to furnish materials or equipment fabricated to a special design)
         proposed for each principal portion of the Work. The Architect will
         promptly reply to the Contractor in writing stating whether or not the
         Owner or the Architect, after due investigation, has reasonable
         objection to any such proposed person or entity. Failure of the Owner
         or Architect to reply promptly shall constitute notice of no reasonable
         objection.

         5.2.2    The Contractor shall not contract with a proposed person or
         entity to whom the Owner or Architect has made reasonable and timely
         objection. The Contractor shall not be required to contract with anyone
         to whom the Contractor has made reasonable objection.

         5.2.3    If the Owner or Architect has reasonable objection to a person
         or entity proposed by the Contractor, the Contractor shall propose
         another to whom the Owner or Architect has no reasonable objection. If
         the proposed but rejected Subcontractor was reasonably capable of
         performing the Work, the Contract Sum and Contract Time shall be
         increased or decreased by the difference, if any, occasioned by such
         change, and an appropriate Change Order shall be

--------------------------------------------------------------------------------
(C) COPYRIGHT 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 BY THE AMERICAN INSTITUTE OF ARCHITECTS. FIFTEENTH
EDITION. REPRODUCTION OF THE MATERIAL HEREIN OR SUBSTANTIAL QUOTATION OF ITS
PROVISIONS WITHOUT WRITTEN PERMISSION OF THE AIA VIOLATES THE COPYRIGHT LAWS OF
THE UNITED STATES AND WILL SUBJECT THE VIOLATE TO LEGAL PROSECUTION. WARNING:
UNLICENSED PHOTOCOPYING VIOLATES U.S. COPYRIGHT LAWS AND WILL SUBJECT THE
VIOLATOR TO LEGAL PROSECUTION. THIS DOCUMENT WAS ELECTRONICALLY PRODUCED WITH
PERMISSION OF THE AIA AND CAN BE REPRODUCED IN ACCORDANCE WITH YOUR LICENSE
WITHOUT VIOLATION UNTIL THE DATE OF EXPIRATION AS NOTED BELOW, EXPIRATION AS
NOTED BELOW. USER DOCUMENT: ALNYLAMGC.AIA -- 3/1/2004.
AIA LICENSE NUMBER 1029845, WHICH EXPIRES ON 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)

AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              24
<PAGE>

         issued before commencement of the substitute Subcontractor's Work.
         However, no increase in the Contract Sum or Contract Time shall be
         allowed for such change unless the Contractor has acted promptly and
         responsively in submitting names as required.

         5.2.4    The Contractor shall not change a Subcontractor, person or
         entity previously selected if the Owner or Architect makes reasonable
         objection to such substitute.

         5.2.5    The Contractor shall require each Subcontractor to furnish
         Performance and Payment Bonds, which shall be a Cost of the Work. If
         the Owner directs the Contractor in writing not to require such Bonds
         from any or all Subcontractors, then any additional costs or delays
         incurred as a result of the Owner's decision not to require Performance
         and Payment Bonds shall be the subject of a Change Order that increases
         the Guaranteed Maximum Price and/or the Contract Time.

         5.3      SUBCONTRACTUAL RELATIONS

         5.3.1    By appropriate agreement, written where legally required for
         validity, the Contractor shall require each Subcontractor, to the
         extent of the Work to be performed by the Subcontractor, to be bound to
         the Contractor by terms of the Contract Documents, and to assume toward
         the Contractor all the obligations and responsibilities, including the
         responsibility for safety of the Subcontractor's Work, which the
         Contractor, by these Documents, assumes toward the Owner and Architect.
         Each subcontract agreement shall preserve and protect the rights of the
         Owner and Architect under the Contract Documents with respect to the
         Work to be performed by the Subcontractor so that subcontracting
         thereof will not prejudice such rights, and shall allow to the
         Subcontractor, unless specifically provided otherwise in the
         subcontract agreement, the benefit of all rights, remedies and redress
         against the Contractor that the Contractor, by the Contract Documents,
         has against the Owner. Where appropriate, the Contractor shall require
         each Subcontractor to enter into similar agreements with
         Sub-subcontractors. The Contractor shall make available to each
         proposed Subcontractor, prior to the execution of the subcontract
         agreement, copies of the Contract Documents to which the Subcontractor
         will be bound, and, upon written request of the Subcontractor, identify
         to the Subcontractor terms and conditions of the proposed subcontract
         agreement which may be at variance with the Contract Documents.
         Subcontractors will similarly make copies of applicable portions of
         such documents available to their respective proposed
         Sub-subcontractors.

         5.4      CONTINGENT ASSIGNMENT OF SUBCONTRACTS

         5.4.1    Each subcontract agreement for a portion of the Work is
         assigned by the Contractor to the Owner provided that:

                  .1       assignment is effective only after termination of the
                           Contract by the Owner for cause pursuant to Paragraph
                           14.2 and only for those subcontract agreements which
                           the Owner accepts by notifying the Subcontractor and
                           Contractor in writing; and

                  .2       assignment is subject to the prior rights of the
                           surety, if any, obligated under bond relating to the
                           Contract.

         5.4.2    Upon such assignment, if the Work has been suspended for more
         than 30 days, the Subcontractor's compensation shall be equitably
         adjusted for increases in cost resulting from the suspension.

ARTICLE 6 CONSTRUCTION BY OWNER OR BY SEPARATE CONTRACTORS

         6.1      OWNER'S RIGHT TO PERFORM CONSTRUCTION AND TO AWARD SEPARATE
                  CONTRACTS

         6.1.1    The Owner reserves the right to perform construction or
         operations related to the Project with the Owner's own forces, and to
         award separate contracts in connection with other portions of the
         Project or other construction or operations on the site under
         Conditions of the Contract identical or substantially similar to these
         including those portions related to insurance

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OK MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              25

<PAGE>

         and waiver of subrogation. If the Contractor claims that delay or
         additional cost is involved because of such action by the Owner, the
         Contractor shall make such Claim as provided in Paragraph 4.3. The
         Contractor acknowledges that the Owner will install certain research
         equipment and furniture in coordination with the work, including
         autoclaves and a cagewasher. The Contractor shall not be entitled to an
         additional compensation hereunder unless in conflict with union
         agreements.

         6.1.2    When separate contracts are awarded for different portions of
         the Project or other construction or operations on the site, the term
         "Contractor" in the Contract Documents in each case shall mean the
         Contractor who executes each separate Owner-Contractor Agreement.

         6.1.3    The Owner shall provide for coordination of the activities of
         the Owner's own forces and of each separate contractor with the Work of
         the Contractor, who shall cooperate with them. The Contractor shall
         participate with other separate contractors and the Owner in reviewing
         their construction schedules when directed to do so. The Contractor
         shall make any revisions to the construction schedule and contract time
         deemed necessary after a joint review and mutual agreement. The
         construction schedules shall then constitute the schedules to be used
         by the Contractor, separate contractors and the Other until
         subsequently revised.

         6.1.4    Unless otherwise provided in the Contract Documents, when the
         Owner performs construction or operations related to the Project with
         the Owner's own forces, the Owner shall be deemed to be subject to the
         same obligations and to have the same rights which apply to the
         Contractor under the Conditions of the Contract, including, without
         excluding others, those stated in Article 3, this Article 6 and
         Articles 10, 11 and 12.

         6.2      MUTUAL RESPONSIBILITY

         6.2.1    The Contractor shall afford the Owner and separate contractors
         reasonable opportunity for introduction and storage of their materials
         and equipment and performance of their activities, and shall connect
         and coordinate the Contractor's construction and operations with theirs
         as required by the Contract Documents.

         6.2.2    If part of the Contractor's Work depends for proper execution
         or results upon construction or operations by the Owner or a separate
         contractor, the Contractor shall, prior to proceeding with that portion
         of the Work, promptly report to the Architect apparent discrepancies or
         defects in such other construction that would render it unsuitable for
         such proper execution and results. Failure of the Contractor so to
         report shall constitute an acknowledgment that the Owner's or separate
         contractor's completed or partially completed construction is fit and
         proper to receive the Contractor's Work, except as to defects not then
         reasonably discoverable.

         6.2.3    The Owner shall be reimbursed by the Contractor for costs
         incurred by the Owner which are payable to a separate contractor
         because of delays, improperly timed activities or defective
         construction of the Contractor. The Owner shall be responsible to the
         Contractor for costs incurred by the Contractor because of delays,
         improperly timed activities, damage to the Work or defective
         construction of a separate contractor.

         6.2.4    The Contractor shall promptly remedy damage wrongfully caused
         by the Contractor to completed or partially completed construction or
         to property of the Owner or separate contractors as provided in
         Subparagraph 10.2.5.

         6.2.5    The Owner and each separate contractor shall have the same
         responsibilities for cutting and patching as are described for the
         Contractor in Subparagraph 3.14.

         6.3      OWNER'S RIGHT TO CLEAN UP

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              26

<PAGE>

         6.3.1    If a dispute arises among the Contractor, separate contractors
         and the Owner as to the responsibility under their respective contracts
         for maintaining the premises and surrounding area free from waste
         materials and rubbish, the Owner may clean up and the Architect will
         allocate the cost among those responsible.

ARTICLE 7 CHANGES IN THE WORK

         7.1      GENERAL

         7.1.1    Changes in the Work may be accomplished after execution of the
         Contract, and without invalidating the Contract, by Change Order,
         Construction Change Directive or order for a minor change in the Work,
         subject to the limitations stated in this Article 7 and elsewhere in
         the Contract Documents.

         7.1.2    A Change Order shall be based upon agreement among the Owner,
         Contractor and Architect; a Construction Change Directive requires
         agreement by the Owner and Architect and may or may not be agreed to by
         the Contractor, an order for a minor change in the Work may be issued
         by the Architect alone.

         7.1.3    Changes in the Work shall be performed under applicable
         provisions of the Contract Documents, and the Contractor shall proceed
         promptly, unless otherwise provided in the Change Order, Construction
         Change Directive or order for a minor change in the Work.

         7.2      CHANGE ORDERS

         7.2.1    A Change Order is a written instrument prepared by the
         Architect and signed by the Owner, Contractor and Architect, stating
         their agreement upon all of the following:

                  .1       change in the Work;

                  .2       the amount of the adjustment, if any, in the Contract
                           Sum; and

                  .3       the extent of the adjustment, if any, in the Contract
                           Time.

         7.2.2    Methods used in determining adjustments to the Contract Sum
         may include those listed in Subparagraph 7.3.3.

         7.3      CONSTRUCTION CHANGE DIRECTIVES

         7.3.1    A Construction Change Directive is a written order prepared by
         the Architect and signed by the Owner and Architect, directing a change
         in the Work prior to agreement on adjustment, if any, in the Contract
         Sum or Contract Time, or both. The Owner may by Construction Change
         Directive, without invalidating the Contract, order changes in the Work
         within the general scope of the Contract consisting of additions,
         deletions or other revisions, the Contract Sum and Contract Time being
         adjusted accordingly.

         7.3.2    A Construction Change Directive shall be used in the absence
         of total agreement on the terms of a Change Order.

         7.3.3    If the Construction Change Directive provides for an
         adjustment to the Contract Sum, the adjustment shall be based on one of
         the following methods:

                  .1       mutual acceptance of a lump sum properly itemized and
                           supported by sufficient substantiating data to permit
                           evaluation;

                  .2       unit prices stated in the Contract Documents or
                           subsequently agreed upon;

                  .3       cost to be determined in a manner agreed upon by the
                           parties and a mutually acceptable fixed or percentage
                           fee; or

                  .4       as provided in Subparagraph 7.3.6.

         7.3.4    Upon receipt of a Construction Change Directive, the
         Contractor shall promptly proceed with the change in the Work involved
         and advise the Architect of the Contractor's

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              27

<PAGE>

         agreement or disagreement with the method, if any, provided in the
         Construction Change Directive for determining the proposed adjustment
         in the Contract Sum or Contract Time.

         7.3.5    A Construction Change Directive signed by the Contractor
         indicates the agreement of the Contractor therewith, including
         adjustment in Contract Sum and Contract Time or the method for
         determining them. Such agreement shall be effective immediately and
         shall be recorded as a Change Order.

         7.3.6    If the Contractor does not respond promptly or disagrees with
         the method for adjustment in the Contract Sum, the method and the
         adjustment shall be determined by the Architect on the basis of
         reasonable expenditures and savings of those performing the Work
         attributable to the change, including, in case of an increase in the
         Contract Sum, a reasonable allowance for overhead and profit. In such
         case, and also under Clause 7.3.3.3, the Contractor shall keep and
         present, in such form as the Architect may prescribe, an itemized
         accounting together with appropriate supporting data. Unless otherwise
         provided in the Contract Documents, costs for the purposes of this
         Subparagraph 7.3.6 shall be limited to the following:

                  .1       costs of labor, including social security, old age
                           and unemployment insurance, fringe benefits required
                           by agreement or custom, and workers' compensation
                           insurance;

                  .2       costs of materials, supplies and equipment, including
                           cost of transportation, whether incorporated or
                           consumed;

                  .3       rental costs of machinery and equipment, exclusive of
                           hand tools, whether rented from the Contractor or
                           others;

                  .4       costs of premiums for all bonds and insurance, permit
                           fees, and sales, use or similar taxes related to the
                           Work; and

                  .5       additional costs of supervision and field office
                           personnel directly attributable to the change.

         7.3.7    The amount of credit to be allowed by the Contractor to the
         Owner for a deletion or change which results in a net decrease in the
         Contract Sum shall be actual net cost as confirmed by the Architect.
         When both additions and credits covering related Work or substitutions
         are involved in a change, the allowance for overhead and profit shall
         be figured on the basis of net increase, if any, with respect to that
         change.

         7.3.8    Pending final determination of the total cost of a
         Construction Change Directive to the Owner, amounts not in dispute for
         such changes in the Work shall be included in Applications for Payment
         accompanied by a Change Order indicating the parties' agreement with
         part or all of such costs. For any portion of such cost that remains in
         dispute, the Architect will make an interim determination for purposes
         of monthly certification for payment for those costs. That
         determination of cost shall adjust the Contract Sum on the same basis
         as a Change Order, subject to the right of either party to disagree and
         assert a claim in accordance with Article 4.

         7.3.9    When the Owner and Contractor agree with the determination
         made by the Architect concerning the adjustments in the Contract Sum
         and Contract Time, or otherwise reach agreement upon the adjustments,
         such agreement shall be effective immediately and shall be recorded by
         preparation and execution of an appropriate Change Order.

         7.4      MINOR CHANGES IN THE WORK

         7.4.1    The Architect with the approval of the Owner's representative
         will have authority to order minor changes in the Work not involving
         adjustment in the Contract Sum or extension of the Contract Time and
         not inconsistent with the intent of the Contract Documents. Such
         changes shall be effected by written order and shall be binding on the
         Owner and Contractor. The Contractor shall carry out such written
         orders promptly.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              28

<PAGE>

ARTICLE 8 TIME

         8.1      DEFINITIONS

         8.1.1    Unless otherwise provided, Contract Time is the period of
         time, including authorized adjustments, allotted in the Contract
         Documents for Substantial Completion of the Work.

         8.1.2    The date of commencement of the Work is the date established
         in the Agreement.

         8.1.3    The date of Substantial Completion is the date certified by
         the Architect in accordance with Paragraph 9.8.

         8.1.4    The term "day" as used in the Contract Documents shall mean
         calendar day unless otherwise specifically defined.

         8.2      PROGRESS AND COMPLETION

         8.2.1    Time limits stated in the Contract Documents are of the
         essence of the Contract. By executing the Agreement the Contractor
         confirms that the Contract Time is a reasonable period for performing
         the Work.

         8.2.2    The Contractor shall not knowingly, except by agreement or
         instruction of the Owner in writing, prematurely commence operations on
         the site or elsewhere prior to the effective date of insurance required
         by Article 11 to be furnished by the Contractor and Owner. The date of
         commencement of the Work shall not be changed by the effective date of
         such insurance. Unless the date of commencement is established by the
         Contract Documents or a notice to proceed given by the Owner, the
         Contractor shall notify the Owner in writing not less than five days or
         other agreed period before commencing the Work to permit the timely
         filing of mortgages, mechanic's liens and other security interests.

         8.2.3    The Contractor shall proceed expeditiously with adequate
         forces and shall achieve Substantial Completion within the Contract
         Time.

         8.3      DELAYS AND EXTENSIONS OF TIME

         8.3.1    If the Contractor is delayed at any time in the commencement
         or progress of the Work by an act or neglect of the Owner or Architect,
         or of an employee of either, or of a separate contractor employed by
         the Owner, or by changes ordered in the Work, or by labor disputes,
         fire, unusual delay in deliveries, unavoidable casualties or other
         causes beyond the Contractor's control, or by delay authorized by the
         Owner pending mediation and arbitration, or by other causes which the
         Architect determines may justify delay, then the Contract Time shall be
         extended by Change Order for such reasonable time as the Architect may
         determine.

         8.3.2    Claims relating to time shall be made in accordance with
         applicable provisions of Paragraph 4.3.

         8.3.3    This Paragraph 8.3 does not preclude recovery of damages for
         delay by either party under other provisions of the Contract Documents.

ARTICLE 9 PAYMENTS AND COMPLETION

         9.1      CONTRACT SUM

         9.1.1    The Contract Sum is stated in the Agreement and, including
         authorized adjustments, is the total amount payable by the Owner to the
         Contractor for performance of the Work under the Contract Documents.

         9.2      SCHEDULE OF VALUES

         9.2.1    Before the first Application for Payment, the Contractor shall
         submit to the Architect a schedule of values allocated to various
         portions of the Work, prepared in such form and

(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              29

<PAGE>

         supported by such data to substantiate its accuracy as the Architect
         may require. This schedule, unless objected to by the Architect, shall
         be used as a basis for reviewing the Contractor's Applications for
         Payment.

         9.3      APPLICATIONS FOR PAYMENT

         9.3.1    At least ten days before the date established for each
         progress payment, the Contractor shall submit to the Architect an
         itemized Application for Payment for operations completed in accordance
         with the schedule of values. Such application shall be notarized, if
         required, and supported by such data substantiating the Contractor's
         right to payment as the Owner or Architect may require, such as copies
         of requisitions from Subcontractors and material suppliers, and
         reflecting retainage if provided for in the Contract Documents.

         9.3.1.1  As provided in Subparagraph 7.3.8, such applications may
         include requests for payment on account of changes in the Work which
         have been properly authorized by Construction Change Directives, or by
         interim determinations of the Architect, but not yet included in Change
         Orders.

         9.3.1.2  Such applications may not include requests for payment for
         portions of the Work for which the Contractor does not intend to pay to
         a Subcontractor or material supplier, unless such Work has been
         performed by others whom the Contractor intends to pay.

         9.3.2    Unless otherwise provided in the Contract Documents, payments
         shall be made on account of materials and equipment delivered and
         suitably stored at the site for subsequent incorporation in the Work.
         If approved in advance by the Owner, payment may similarly be made for
         materials and equipment suitably stored off the site at a location
         agreed upon in writing. Payment for materials and equipment stored on
         or off the site shall be conditioned upon compliance by the Contractor
         with procedures satisfactory to the Owner to establish the Owner's
         title to such materials and equipment or otherwise protect the Owner's
         interest, and shall include the costs of applicable insurance, storage
         and transportation to the site for such materials and equipment stored
         off the site.

         9.3.3    The Contractor warrants that title to all Work covered by an
         Application for Payment will pass to the Owner no later than the time
         of payment. The Contractor further warrants that upon submittal of an
         Application for Payment all Work for which Certificates for Payment
         have been previously issued and payments received from the Owner shall,
         to the best of the Contractor's knowledge, information and belief, be
         free and clear of liens, claims, security interests or encumbrances in
         favor of the Contractor, Subcontractors, material suppliers, or other
         persons or entities making a claim by reason of having provided labor,
         materials and equipment relating to the Work.

         9.4      CERTIFICATES FOR PAYMENT

         9.4.1    The Architect will, within seven days after receipt of the
         Contractor's Application for Payment, either issue to the Owner a
         Certificate for Payment, with a copy to the Contractor, for such amount
         as the Architect determines is properly due, or notify the Contractor
         and Owner in writing of the Architect's reasons for withholding
         certification in whole or in part as provided in Subparagraph 9.5.1.

         9.4.2    The issuance of a Certificate for Payment will constitute a
         representation by the Architect to the Owner, based on the Architect's
         evaluation of the Work and the data comprising the Application for
         Payment, that the Work has progressed to the point indicated and that,
         to the best of the Architect's knowledge, information and belief, the
         quality of the Work is in accordance with the Contract Documents. The
         foregoing representations are subject to an evaluation of the Work for
         conformance with the Contract Documents upon Substantial Completion, to
         results of subsequent tests and inspections, to correction of minor
         deviations from the Contract Documents prior to completion and to
         specific qualifications expressed by the Architect. The issuance of a
         Certificate for Payment will further constitute a representation

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              30

<PAGE>

         that the Contractor is entitled to payment in the amount certified.
         However, the issuance of a Certificate for Payment will not be a
         representation that the Architect has (1) made exhaustive or continuous
         on-site inspections to check the quality or quantity of the Work, (2)
         reviewed construction means, methods, techniques, sequences or
         procedures, (3) reviewed copies of requisitions received from
         Subcontractors and material suppliers and other data requested by the
         Owner to substantiate the Contractor's right to payment, or (4) made
         examination to ascertain how or for what purpose the Contractor has
         used money previously paid on account of the Contract Sum.

         9.5      DECISIONS TO WITHHOLD CERTIFICATION

         9.5.1    The Architect may withhold a Certificate for Payment in whole
         or in part, to the extent reasonably necessary to protect the Owner, if
         in the Architect's opinion the representations to the Owner required by
         Subparagraph 9.4.2 cannot be made. If the Architect is unable to
         certify payment in the amount of the Application, the Architect will
         notify the Contractor and Owner as provided in Subparagraph 9.4.1. If
         the Contractor and Architect cannot agree on a revised amount, the
         Architect will promptly issue a Certificate for Payment for the amount
         for which the Architect is able to make such representations to the
         Owner. The Architect may also withhold a Certificate for Payment or,
         because of subsequently discovered evidence, may nullify the whole or a
         part of a Certificate for Payment previously issued, to such extent as
         may be necessary in the Architect's opinion to protect the Owner from
         loss for which the Contractor is responsible, including loss resulting
         from acts and omissions described in Subparagraph 3.3.2, because of:

                  .1       defective Work not remedied;

                  .2       third party claims filed or reasonable evidence
                           indicating probable filing of such claims unless
                           security acceptable to the Owner is provided by the
                           Contractor;

                  .3       failure of the Contractor to make payments properly
                           to Subcontractors or for labor, materials or
                           equipment;

                  .4       reasonable evidence that the Work cannot be completed
                           for the unpaid balance of the Contract Sum;

                  .5       damage to the Owner or another contractor;

                  .6       reasonable evidence that the Work will not be
                           completed within the Contract Time, and that the
                           unpaid balance would not be adequate to cover actual
                           or liquidated damages for the anticipated delay; or

                  .7       persistent failure to carry out the Work in
                           accordance with the Contract Documents.

         9.5.2    When the above reasons for withholding certification are
         removed, certification will be made for amounts previously withheld.

         9.6      PROGRESS PAYMENTS

         9.6.1    After the Architect has issued a Certificate for Payment, the
         Owner shall make payment in the manner and within the time provided in
         the Contract Documents, and shall so notify the Architect.

         9.6.2    The Contractor shall promptly pay each Subcontractor, upon
         receipt of payment from the Owner, out of the amount paid to the
         Contractor on account of such Subcontractor's portion of the Work, the
         amount to which said Subcontractor is entitled, reflecting percentages
         actually retained from payments to the Contractor on account of such
         Subcontractor's portion of the Work. The Contractor shall, by
         appropriate agreement with each Subcontractor, require each
         Subcontractor to make payments to Sub-subcontractors in a similar
         manner.

         9.6.3    The Architect will, on request, furnish to a Subcontractor, if
         practicable, information regarding percentages of completion or amounts
         applied for by the Contractor and action taken thereon by the Architect
         and Owner on account of portions of the Work done by such
         Subcontractor.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              31

<PAGE>

         9.6.4    Neither the Owner nor Architect shall have an obligation to
         pay or to see to the payment of money to a Subcontractor except as may
         otherwise be required by law.

         9.6.5    Payment to material suppliers shall be treated in a manner
         similar to that provided in Subparagraphs 9.6.2, 9.6.3 and 9.6.4.

         9.6.6    A Certificate for Payment, a progress payment, or partial or
         entire use or occupancy of the Project by the Owner shall not
         constitute acceptance of Work not in accordance with the Contract
         Documents.

         9.6.7    Unless the Contractor provides the Owner with a payment bond
         in the full penal sum of the Contract Sum, payments received by the
         Contractor for Work properly performed by Subcontractors and suppliers
         shall be held by the Contractor for those Subcontractors or suppliers
         who performed Work or furnished materials, or both, under contract with
         the Contractor for which payment was made by the Owner. Nothing
         contained herein shall require money to be placed in a separate account
         and not commingled with money of the Contractor, shall create any
         fiduciary liability or tort liability on the part of the Contractor for
         breach of trust or shall entitle any person or entity to an award of
         punitive damages against the Contractor for breach of the requirements
         of this provision.

         9.7      FAILURE OF PAYMENT

         9.7.1    If the Architect does not issue a Certificate for Payment,
         through no fault of the Contractor, within seven days after receipt of
         the Contractor's Application for Payment, or if the Owner does not pay
         the Contractor within seven days after the date established in the
         Contract Documents the amount certified by the Architect or awarded by
         arbitration, then the Contractor may, upon seven additional days'
         written notice to the Owner and Architect, stop the Work until payment
         of the amount owing has been received. The Contract Time shall be
         extended appropriately and the Contract Sum shall be increased by the
         amount of the Contractor's reasonable costs of shut-down, delay and
         start-up, plus interest as provided for in the Contract Documents.

         9.8      SUBSTANTIAL COMPLETION

         9.8.1    Substantial Completion is the stage in the progress of the
         Work when the Work or designated portion thereof is sufficiently
         complete in accordance with the Contract Documents so that the Owner
         can occupy or utilize the Work for its intended use. The Contractor's
         obtaining a Certificate of Occupancy for the project from the City of
         Cambridge is an express condition precedent to Substantial Completion.

         9.8.2    When the Contractor considers that the Work, or a portion
         thereof which the Owner agrees to accept separately, is substantially
         complete, the Contractor shall prepare and submit to the Architect a
         comprehensive list of items to be completed or corrected prior to final
         payment. Failure to include an item on such list does not alter the
         responsibility of the Contractor to complete all Work in accordance
         with the Contract Documents.

         9.8.3    Upon receipt of the Contractor's list, the Architect will make
         an inspection to determine whether the Work or designated portion
         thereof is substantially complete. If the Architect's inspection
         discloses any item, whether or not included on the Contractor's list,
         which is not sufficiently complete in accordance with the Contract
         Documents so that the Owner can occupy or utilize the Work or
         designated portion thereof for its intended use, the Contractor shall,
         before issuance of the Certificate of Substantial Completion, complete
         or correct such item upon notification by the Architect. In such case,
         the Contractor shall then submit a request for another inspection by
         the Architect to determine Substantial Completion.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              32

<PAGE>

         9.8.4    When the Work or designated portion thereof is substantially
         complete, the Architect will prepare a Certificate of Substantial
         Completion which shall establish the date of Substantial Completion,
         shall establish responsibilities of the Owner and Contractor for
         security, maintenance, heat, utilities, damage to the Work and
         insurance, and shall fix the time within which the Contractor shall
         finish all items on the list accompanying the Certificate. Warranties
         required by the Contract Documents shall commence on the date of
         Substantial Completion of the Work or designated portion thereof unless
         otherwise provided in the Certificate of Substantial Completion.

         9.8.5    The Certificate of Substantial Completion shall be submitted
         to the Owner and Contractor for their written acceptance of
         responsibilities assigned to them in such Certificate. Upon such
         acceptance and consent of surety, if any, the Owner shall make payment
         of retainage applying to such Work or designated portion thereof. Such
         payment shall be adjusted for Work that is incomplete or not in
         accordance with the requirements of the Contract Documents.

         9.9      PARTIAL OCCUPANCY OR USE

         9.9.1    The Owner may occupy or use any completed or partially
         completed portion of the Work at any stage when such portion is
         designated by separate agreement with the Contractor, provided such
         occupancy or use is consented to by the insurer as required under
         Clause 11.4.1.5 and authorized by public authorities having
         jurisdiction over the Work. Such partial occupancy or use may commence
         whether or not the portion is substantially complete, provided the
         Owner and Contractor have accepted in writing the responsibilities
         assigned to each of them for payments, retainage, if any, security,
         maintenance, heal, utilities, damage to the Work and insurance, and
         have agreed in writing concerning the period for correction of the Work
         and commencement of warranties required by the Contract Documents. When
         the Contractor considers a portion substantially complete, the
         Contractor shall prepare and submit a list to the Architect as provided
         under Subparagraph 9.8.2. Consent of the Contractor to partial
         occupancy or use shall not be unreasonably withheld. The stage of the
         progress of the Work shall be determined by written agreement between
         the Owner and Contractor or, if no agreement is reached, by decision of
         the Architect.

         9.9.2    Immediately prior to such partial occupancy or use, the Owner,
         Contractor and Architect shall jointly inspect the area to be occupied
         or portion of the Work to be used in order to determine and record the
         condition of the Work.

         9.9.3    Unless otherwise agreed upon, partial occupancy or use of a
         portion or portions of the Work shall not constitute acceptance of Work
         not complying with the requirements of the Contract Documents.

         9.10     FINAL COMPLETION AND FINAL PAYMENT

         9.10.1   Upon receipt of written notice that the Work is ready for
         final inspection and acceptance and upon receipt of a final Application
         for Payment, the Architect will promptly make such inspection and, when
         the Architect finds the Work acceptable under the Contract Documents
         and the Contract fully performed, the Architect will promptly issue a
         final Certificate for Payment stating that to the best of the
         Architect's knowledge, information and belief, and on the basis of the
         Architect's on-site visits and inspections, the Work has been completed
         in accordance with terms and conditions of the Contract Documents and
         that the entire balance found to be due the Contractor and noted in the
         final Certificate is due and payable. The Architect's final Certificate
         for Payment will constitute a further representation that conditions
         listed in Subparagraph 9.10.2 as precedent to the Contractor's being
         entitled to final payment have been fulfilled.

         9.10.2   Neither final payment nor any remaining retained percentage
         shall become due until the Contractor submits to the Architect (i) an
         affidavit that payrolls, bills for materials and equipment, and other
         indebtedness connected with the Work for which the Owner or the

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              33

<PAGE>

         Owner's property might be responsible or encumbered (less amounts
         withheld by Owner) have been paid or otherwise satisfied, (2) a
         certificate evidencing that insurance required by the Contract
         Documents to remain in force after final payment is currently in effect
         and will not be canceled or allowed to expire until at least 30 days'
         prior written notice has been given to the Owner, (3) a written
         statement that the Contractor knows of no substantial reason that the
         insurance will not be renewable to cover the period required by the
         Contract Documents, (4) consent of surely, if any, to final payment and
         (5), if required by the Owner, other data establishing payment or
         satisfaction of obligations, such as receipts, releases and waivers of
         liens, claims, security interests or encumbrances arising out of the
         Contract, to the extent and in such form as may be designated by the
         Owner. If a Subcontractor refuses to furnish a release or waiver
         required by the Owner, the Contractor may furnish a bond satisfactory
         to the Owner to indemnify the Owner against such lien. If such lien
         remains unsatisfied after payments are made, the Contractor shall
         refund to the Owner all money that the Owner may be compelled to pay in
         discharging such lien, including all costs and reasonable attorneys'
         fees.

         9.10.3   If, after Substantial Completion of the Work, final completion
         thereof is materially delayed through no fault of the Contractor or by
         issuance of Change Orders affecting final completion, and the Architect
         so confirms, the Owner shall, upon application by the Contractor and
         certification by the Architect, and without terminating the Contract,
         make payment of the balance due for that portion of the Work fully
         completed and accepted. If the remaining balance for Work not fully
         completed or corrected is less than retainage stipulated in the
         Contract Documents, and if bonds have been furnished, the written
         consent of surety to payment of the balance due for that portion of the
         Work fully completed and accepted shall be submitted by the Contractor
         to the Architect prior to certification of such payment. Such payment
         shall be made under terms and conditions governing final payment,
         except that it shall not constitute a waiver of claims.

         9.10.4   The making of final payment shall constitute a waiver of
         Claims by the Owner except those arising from:

                  .1       liens, Claims, security interests or encumbrances
                           arising out of the Contract and unsettled;

                  .2       failure of the Work to comply with the requirements
                           of the Contract Documents; or

                  .3       terms of special warranties required by the Contract
                           Documents.

         9.10.5   Acceptance of final payment by the Contractor, a Subcontractor
         or material supplier shall constitute a waiver of claims by that payee
         except those previously made in writing and identified by that payee as
         unsettled at the time of final Application for Payment.

ARTICLE 10 PROTECTION OF PERSONS AND PROPERTY

         10.1     SAFETY PRECAUTIONS AND PROGRAMS

         10.1.1   The Contractor shall be responsible for initiating,
         maintaining and supervising all safety precautions and programs in
         connection with the performance of the Contract.

         10.2     SAFETY OF PERSONS AND PROPERTY

         10.2.1   The Contractor shall take reasonable precautions for safety
         of, and shall provide reasonable protection to prevent damage, injury
         or loss to:

                  .1       employees on the Work and other persons who may be
                           affected thereby;

                  .2       the Work and materials and equipment to be
                           incorporated therein, whether in storage on or off
                           the site, under care, custody or control of the
                           Contractor or the Contractor's Subcontractors or
                           Sub-subcontractors; and

                  .3       other property at the site or adjacent thereto, such
                           as trees, shrubs, lawns, walks, pavements, roadways,
                           structures and utilities not designated for removal,
                           relocation or replacement in the course of
                           construction.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced With
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              34

<PAGE>

         10.2.2   The Contractor shall give notices and comply with applicable
         laws, ordinances, rules, regulations and lawful orders of public
         authorities bearing on safety of persons or property or their
         protection from damage, injury or loss.

         10.2.3   The Contractor shall erect and maintain, as required by
         existing conditions and performance of the Contract, reasonable
         safeguards for safety and protection, including posting danger signs
         and other warnings against hazards, promulgating safety regulations and
         notifying owners and users of adjacent sites and utilities.

         10.2.4   When use or storage of explosives or other hazardous materials
         or equipment or unusual methods are necessary for execution of the
         Work, the Contractor shall exercise utmost care and carry on such
         activities under supervision of properly qualified personnel.

         10.2.5   The Contractor shall promptly remedy damage and loss (other
         than damage or loss insured under property insurance required by the
         Contract Documents) to property referred to in Clauses 10.2.1.2 and
         10.11.3 caused in whole or in part by the Contractor, a Subcontractor,
         a Sub-subcontractor, or anyone directly or indirectly employed by any
         of them, or by anyone for whose acts they may be liable and for which
         the Contractor is responsible under Clauses 10.2.1.2 and 10.2.1.3,
         except damage or loss attributable to acts or omissions of the Owner or
         Architect or anyone directly or indirectly employed by either of them,
         or by anyone for whose acts either of them may be liable, and not
         attributable to the fault or negligence of the Contractor. The
         foregoing obligations of the Contractor are in addition to the
         Contractor's obligations under Paragraph 3.18.

         10.2.6   The Contractor shall designate a responsible member of the
         Contractor's organization at the site whose duty shall be the
         prevention of accidents. This person shall be the Contractor's
         superintendent unless otherwise designated by the Contractor in writing
         to the Owner and Architect.

         10.2.7   The Contractor shall not load or permit any part of the
         construction or site to be loaded so as to endanger its safety.

         10.3     HAZARDOUS MATERIALS

         10.3.1   If reasonable precautions will be inadequate to prevent
         foreseeable bodily injury or death to persons resulting from a material
         or substance, including any hazardous, contaminated or toxic material
         as defined in Federal or State Laws or Regulations, encountered on the
         site by the Contractor, the Contractor shall, upon recognizing the
         condition, immediately stop Work in the affected area and report the
         condition to the Owner and Architect in writing.

         10.3.2   The Owner shall obtain the services of a licensed laboratory
         to verify the presence or absence of the material or substance reported
         by the Contractor and, in the event such material or substance is found
         to be present, to verify that it has been rendered harmless. Unless
         otherwise required by the Contract Documents, the Owner shall furnish
         in writing to the Contractor and Architect the names and qualifications
         of persons or entities who are to perform tests verifying the presence
         or absence of such material or substance or who are to perform the task
         of removal or safe containment of such material or substance. The
         Contractor and the Architect will promptly reply to the Owner in
         writing stating whether or not either has reasonable objection to the
         persons or entities proposed by the Owner. If either the Contractor or
         Architect has an objection to a person or entity proposed by the Owner,
         the Owner shall propose another to whom the Contractor and the
         Architect have no reasonable objection. When the material or substance
         has been found to be harmless or has been rendered harmless, Work in
         the affected area shall resume upon written agreement of the Owner and
         Contractor. The Contract Time shall be extended appropriately and the
         Contract Sum shall be increased in

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              35

<PAGE>

         the amount of the Contractor's reasonable additional costs of
         shut-down, delay and start-up, which adjustments shall be accomplished
         as provided in Article 7.

         10.3.3   To the fullest extent permitted by law, the Owner shall
         indemnify and hold harmless the Contractor, Subcontractors, Architect,
         Architect's consultants and agents and employees of any of them from
         and against claims, damages, losses and expenses, including but not
         limited to attorneys' fees, arising out of or resulting from
         performance of the Work in the affected area if in fact the material or
         substance presents the risk of bodily injury or death as described in
         Subparagraph 10.3.1 and has not been found to be harmless or rendered
         harmless, provided that such claim, damage, loss or expense is
         attributable to bodily injury, sickness, disease or death, or to injury
         to or destruction of tangible property (other than the Work itself) and
         provided that such damage, loss or expense is not due to the sole
         negligence of a party seeking indemnity.

         10.4     The Owner shall not be responsible under Paragraph 10.3 for
         materials and substances brought to the site by the Contractor unless
         such materials or substances were required by the Contract Documents.

         10.5     If, without negligence on the part of the Contractor, the
         Contractor is held liable for the cost of remediation of a hazardous
         material or substance solely by reason of performing Work as required
         by the Contract Documents, the Owner shall indemnify the Contractor for
         all cost and expense thereby incurred.

         10.6     EMERGENCIES

         10.6.1   In an emergency affecting safety of persons or property, the
         Contractor shall act, at the Contractor's discretion, to prevent
         threatened damage, injury or loss. Additional compensation or extension
         of time claimed by the Contractor on account of an emergency shall be
         determined as provided in Paragraph 4.3 and Article 7.

ARTICLE 11 INSURANCE AND BONDS

         11.1     CONTRACTOR'S LIABILITY INSURANCE

         11.1.1   The Contractor shall purchase from and maintain in a company
         or companies lawfully authorized to do business in the jurisdiction in
         which the Project is located such insurance as will protect the
         Contractor from claims set forth below which may arise out of or result
         from the Contractor's operations under the Contract and for which the
         Contractor may be legally liable, whether such operations be by the
         Contractor or by a Subcontractor or by anyone directly or indirectly
         employed by any of them, or by anyone for whose acts any of them may be
         liable:

                  .1       claims under workers' compensation, disability
                           benefit and other similar employee benefit acts which
                           are applicable to the Work to be performed;

                  .2       claims for damages because of bodily injury,
                           occupational sickness or disease, or death of the
                           Contractor's employees;

                  .3       claims for damages because of bodily injury, sickness
                           or disease, or death of any person other than the
                           Contractor's employees;

                  .4       claims for damages insured by usual personal injury
                           liability coverage;

                  .5       claims for damages, other than to the Work itself,
                           because of injury to or destruction of tangible
                           property, including loss of use resulting therefrom;

                  .6       claims for damages because of bodily injury, death of
                           a person or property damage arising out of ownership,
                           maintenance or use of a motor vehicle;

                  .7       claims for bodily injury or property damage arising
                           out of completed operations; and

                  .8       claims involving contractual liability insurance
                           applicable to the Contractor's obligations under
                           Paragraph 3.18.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              36

<PAGE>

         11.1.2   The insurance required by Subparagraph 11.1.1 shall be written
         for not less than limits of liability specified in the Contract
         Documents or required by law, whichever coverage is greater. Coverages,
         whether written on an occurrence or claims-made basis, shall be
         maintained without interruption from date of commencement of the Work
         until date of final payment and termination of any coverage required to
         be maintained after final payment.

         11.1.3   Certificates of insurance acceptable to the Owner shall be
         filed with the Owner prior to commencement of the Work. These
         certificates and the insurance policies required by this Paragraph 11.1
         shall contain a provision that coverages afforded under the policies
         will not be canceled or allowed to expire until at least 30 days' prior
         written notice has been given to the Owner. If any of the foregoing
         insurance coverages are required to remain in force after final payment
         and are reasonably available, an additional certificate evidencing
         continuation of such coverage shall be submitted with the final
         Application for Payment as required by Subparagraph 9.10.2. Information
         concerning reduction of coverage on account of revised limits or claims
         paid under the General Aggregate, or both, shall be furnished by the
         Contractor with reasonable promptness in accordance with the
         Contractor's information and belief.

         11.2     OWNER'S LIABILITY INSURANCE

         11.2.1   The Owner shall be responsible for purchasing and maintaining
         the Owner's usual liability insurance.

         11.4     PROPERTY INSURANCE

         11.4.1   Unless otherwise provided, the Owner shall purchase and
         maintain, in a company or companies lawfully authorized to do business
         in the jurisdiction in which the Project is located, property insurance
         written on a builder's risk "all-risk" or equivalent policy form in the
         amount of the initial Contract Sum, plus value of subsequent Contract
         modifications and cost of materials supplied or installed by others,
         comprising total value for the entire Project at the site on a
         replacement cost basis without optional deductibles. Such property
         insurance shall be maintained, unless otherwise provided in the
         Contract Documents or otherwise agreed in writing by all persons and
         entities who are beneficiaries of such insurance, until final payment
         has been made as provided in Paragraph 9.10 or until no person or
         entity other than the Owner has an insurable interest in the property
         required by this Paragraph 11.4 to be covered, whichever is later. This
         insurance shall include interests of the Owner, the Contractor,
         Subcontractors and Sub-subcontractors in the Project.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              37

<PAGE>

         11.4.1.1 Property insurance shall be on an "all-risk" or equivalent
         policy form and shall include, without limitation, insurance against
         the perils of fire (with extended coverage) and physical loss or damage
         including, without duplication of coverage, theft, vandalism, malicious
         mischief, collapse, earthquake, flood, windstorm, falsework, testing
         and startup, temporary buildings and debris removal including
         demolition occasioned by enforcement of any applicable legal
         requirements, and shall cover reasonable compensation for Architect's
         and Contractor's services and expenses required as a result of such
         insured loss.

         11.4.1.2 If the Owner does not intend to purchase such property
         insurance required by the Contract and with all of the coverages in the
         amount described above, the Owner shall so inform the Contractor in
         writing prior to commencement of the Work. The Contractor may then
         effect insurance which will protect the interests of the Contractor,
         Subcontractors and Sub-subcontractors in the Work, and by appropriate
         Change Order the cost thereof shall be charged to the Owner. If the
         Contractor is damaged by the failure or neglect of the Owner to
         purchase or maintain insurance as described above, without so notifying
         the Contractor in writing, then the Owner shall bear all reasonable
         costs properly attributable thereto.

         11.4.1.3 If the property insurance requires deductibles, the Owner
         shall pay costs not covered because of such deductibles.

         11.4.1.4 This property insurance shall cover portions of the Work
         stored off the site, and also portions of the Work in transit.

         11.4.1.5 Partial occupancy or use in accordance with Paragraph 9.9
         shall not commence until the insurance company or companies providing
         properly insurance have consented to such partial occupancy or use by
         endorsement or otherwise. The Owner and the Contractor shall take
         reasonable steps to obtain consent of the insurance company or
         companies and shall, without mutual written consent, take no action
         with respect to partial occupancy or use that would cause cancellation,
         lapse or reduction of insurance.

         11.4.3   Loss of Use Insurance. The Owner, at the Owner's option, may
         purchase and maintain such insurance as will insure the Owner against
         loss of use of the Owner's property due to fire or other hazards,
         however caused. The Owner waives all rights of action against the
         Contractor for loss of use of the Owner's property, including
         consequential losses due to fire or other hazards however caused.

         11.4.4   If the Contractor requests in writing that insurance for risks
         other than those described herein or other special causes of loss be
         included in the property insurance policy, the Owner shall, if
         possible, include such insurance, and the cost thereof shall be charged
         to the Contractor by appropriate Change Order.

         11.4.5   If during the Project construction period the Owner insures
         properties, real or personal or both, at or adjacent to the site by
         property insurance under policies separate from those insuring the
         Project, or if after final payment property insurance is to be provided
         on the completed Project through a policy or policies other than those
         insuring the Project during the construction period, the Owner shall
         waive all rights in accordance with the terms of Subparagraph 11.4.7
         for damages caused by fire or other causes of loss covered by this
         separate property insurance. All separate policies shall provide this
         waiver of subrogation by endorsement or otherwise.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201-1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              38

<PAGE>

         11.4.6   Before an exposure to loss may occur, the Owner shall file
         with the Contractor a copy of each policy that includes insurance
         coverages required by this Paragraph 11.4. Each policy shall contain
         all generally applicable conditions, definitions, exclusions and
         endorsements related to this Project. Each policy shall contain a
         provision that the policy will not be canceled or allowed to expire,
         and that its limits will not be reduced, until at least 30 days' prior
         written notice has been given to the Contractor.

         11.4.7   Waivers of Subrogation. The Owner and Contractor waive all
         rights against (1) each other and any of their subcontractors,
         sub-subcontractors, agents and employees, each of the other, and (2)
         the Architect, Architect's consultants, separate contractors described
         in Article 6, if any, and any of their subcontractors,
         sub-subcontractors, agents and employees, for damages caused by fire or
         other causes of loss to the extent covered by property insurance
         obtained pursuant to this Paragraph 11.4 or other property insurance
         applicable to the Work, except such rights as they have to proceeds of
         such insurance held by the Owner as fiduciary. The Owner or Contractor,
         as appropriate, shall require of the Architect, Architect's
         consultants, separate contractors described in Article 6, if any, and
         the subcontractors, sub-subcontractors, agents and employees of any of
         them, by appropriate agreements, written where legally required for
         validity, similar waivers each in favor of other parties enumerated
         herein. The policies shall provide such waivers of subrogation by
         endorsement or otherwise. A waiver of subrogation shall be effective as
         to a person or entity even though that person or entity would otherwise
         have a duty of indemnification, contractual or otherwise, did not pay
         the insurance premium directly or indirectly, and whether or not the
         person or entity had an insurable interest in the property damaged.

         11.4.8   A loss insured under Owner's property insurance shall be
         adjusted by the Owner as fiduciary and made payable to the Owner as
         fiduciary for the insureds, as their interests may appear, subject to
         requirements of any applicable mortgagee clause and of Subparagraph
         11.4.10. The Contractor shall pay Subcontractors their just shares of
         insurance proceeds received by the Contractor, and by appropriate
         agreements, written where legally required for validity, shall require
         Subcontractors to make payments to their Sub-subcontractors in similar
         manner.

         11.4.9   If required in writing by a party in interest, the Owner as
         fiduciary shall, upon occurrence of an insured loss, give bond for
         proper performance of the Owner's duties. The cost of required bonds
         shall be charged against proceeds received as fiduciary. The Owner
         shall deposit in a separate account proceeds so received, which the
         Owner shall distribute in accordance with such agreement as the parties
         in interest may reach, or in accordance with an arbitration award in
         which case the procedure shall be as provided in Paragraph 4.6. If
         after such loss no other special agreement is made and unless the Owner
         terminates the Contract for convenience, replacement of damaged
         property shall be performed by the Contractor after notification of a
         Change in the Work in accordance with Article 7.

         11.4.10  The Owner as fiduciary shall have power to adjust and settle a
         loss with insurers unless one of the parties in interest shall object
         in writing within five days after occurrence of loss to the Owner's
         exercise of this power, if such objection is made, the dispute shall be
         resolved as provided in Paragraphs 4.5 and 4.6. The Owner as fiduciary
         shall, in the case of arbitration, make settlement with insurers in
         accordance with directions of the arbitrators. If distribution of
         insurance proceeds by arbitration is required, the arbitrators will
         direct such distribution.

         11.5     PERFORMANCE BOND AND PAYMENT BOND

         11.5.1   The Owner shall have the right to require the Contractor to
         furnish bonds covering faithful performance of the Contract and payment
         of obligations arising thereunder as stipulated in bidding requirements
         or specifically required in the Contract Documents on the date of
         execution of the Contract.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              39

<PAGE>

         11.5.2   Upon the request of any person or entity appearing to be a
         potential beneficiary of bonds covering payment of obligations arising
         under the Contract, the Contractor shall promptly furnish a copy of the
         bonds or shall permit a copy to be made.

ARTICLE 12 UNCOVERING AND CORRECTION OF WORK

         12.1     UNCOVERING OF WORK

         12.1.1   If a portion of the Work is covered contrary to the
         Architect's request or to requirements specifically expressed in the
         Contract Documents, it must, if required in writing by the Architect,
         be uncovered for the Architect's examination and be replaced at the
         Contractor's expense without change in the Contract Time.

         12.1.2   If a portion of the Work has been covered which the Architect
         has not specifically requested to examine prior to its being covered,
         the Architect may request to see such Work and it shall be uncovered by
         the Contractor. If such Work is in accordance with the Contract
         Documents, costs of uncovering and replacement shall, by appropriate
         Change Order, be at the Owner's expense. If such Work is not in
         accordance with the Contract Documents, correction shall be at the
         Contractor's expense unless the condition was caused by the Owner or a
         separate contractor in which event the Owner shall be responsible for
         payment of such costs.

         12.2     CORRECTION OF WORK

         12.2.1   BEFORE OR AFTER SUBSTANTIAL COMPLETION

         12.2.1.1 The Contractor shall promptly correct Work rejected by the
         Architect or failing to conform to the requirements of the Contract
         Documents, whether discovered before or after Substantial Completion
         and whether or not fabricated, installed or completed. Costs of
         correcting such rejected Work, including additional testing and
         inspections and compensation for the Architect's services and expenses
         made necessary thereby, shall be at the Contractor's expense.

         12.2.2   AFTER SUBSTANTIAL COMPLETION

         12.2.2.1 In addition to the Contractor's obligations under Paragraph
         3.5, if, within one year after the date of Substantial Completion of
         the Work or designated portion thereof or after the date for
         commencement of warranties established under Subparagraph 9.9.1, or by
         terms of an applicable special warranty required by the Contract
         Documents, any of the Work is found to be not in accordance with the
         requirements of the Contract Documents, the Contractor shall correct it
         promptly after receipt of written notice from the Owner to do so unless
         the Owner has previously given the Contractor a written acceptance of
         such condition. The Owner shall give such notice promptly after
         discovery of the condition. During the one-year period for correction
         of Work, if the Owner fails to notify the Contractor and give the
         Contractor an opportunity to make the correction, the Owner waives the
         rights to require correction by the Contractor and to make a claim for
         breach of warranty. If the Contractor fails to correct nonconforming
         Work within a reasonable time during that period after receipt of
         notice from the Owner or Architect, the Owner may correct it in
         accordance with Paragraph 2.4.

         12.2.2.2 The one-year period for correction of Work shall be extended
         with respect to portions of Work first performed after Substantial
         Completion by the period of time between Substantial Completion and the
         actual performance of the Work.

         12.2.2.3 The one-year period for correction of Work shall not be
         extended by corrective Work performed by the Contractor pursuant to
         this Paragraph 12.2.

         12.2.3   The Contractor shall remove from the site portions of the Work
         which are not in accordance with the requirements of the Contract
         Documents and are neither corrected by the Contractor nor accepted by
         the Owner.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              40

<PAGE>

         12.2.4   The Contractor shall bear the cost of correcting destroyed or
         damaged construction, whether completed or partially completed, of the
         Owner or separate contractors caused by the Contractor's correction or
         removal of Work which is not in accordance with the requirements of the
         Contract Documents.

         12.2.5   Nothing contained in this Paragraph 12.2 shall be construed to
         establish a period of limitation with respect to other obligations
         which the Contractor might have under the Contract Documents.
         Establishment of the one-year period for correction of Work as
         described in Subparagraph 12.2.2 relates only to the specific
         obligation of the Contractor to correct the Work, and has no
         relationship to the time within which the obligation to comply with the
         Contract Documents may be sought to be enforced, nor to the time within
         which proceedings may be commenced to establish the Contractor's
         liability with respect to the Contractor's obligations other than
         specifically to correct the Work.

         12.3     ACCEPTANCE OF NONCONFORMING WORK

         12.3.1   If the Owner prefers to accept Work which is not in accordance
         with the requirements of the Contract Documents, the Owner may do so
         instead of requiring its removal and correction, in which case the
         Contract Sum will be reduced as appropriate and equitable. Such
         adjustment shall be effected whether or not final payment has been
         made.

ARTICLE 13 MISCELLANEOUS PROVISIONS

         13.1     GOVERNING LAW

         13.1.1   The Contract shall be governed by the law of the place where
         the Project is located.

         13.2     SUCCESSORS AND ASSIGNS

         13.2.1   The Owner and Contractor respectively bind themselves, their
         partners, successors, assigns and legal representatives to the other
         party hereto and to partners, successors, assigns and legal
         representatives of such other party in respect to covenants, agreements
         and obligations contained in the Contract Documents. Except as provided
         in Subparagraph 13.2.2, neither party to the Contract shall assign the
         Contract as a whole without written consent of the other. If either
         party attempts to make such an assignment without such consent, that
         party shall nevertheless remain legally responsible for all obligations
         under the Contract.

         13.2.2   The Owner may, without consent of the Contractor, assign the
         Contract to an institutional lender providing construction financing
         for the Project. In such event, the lender shall assume the Owner's
         rights and obligations under the Contract Documents. The Contractor
         shall execute all consents reasonably required to facilitate such
         assignment.

         13.3     WRITTEN NOTICE

         13.3.1   Written notice shall be deemed to have been duly served if
         delivered in person to the individual or a member of the firm or entity
         or to an officer of the corporation for which it was intended, or if
         delivered at or sent by registered or certified mail to the last
         business address known to the party giving notice.

         13.4     RIGHTS AND REMEDIES

         13.4.1   Duties and obligations imposed by the Contract Documents and
         rights and remedies available thereunder shall be in addition to and
         not a limitation of duties, obligations, rights and remedies otherwise
         imposed or available by law.

         13.4.2   No action or failure to act by the Owner, Architect or
         Contractor shall constitute a waiver of a right or duty afforded them
         under the Contract, nor shall such action or failure to act constitute
         approval of or acquiescence in a breach thereunder, except as may be
         specifically agreed in writing.

         13.5     TESTS AND INSPECTIONS

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              41

<PAGE>

         13.5.1   Tests, inspections and approvals of portions of the Work
         required by the Contract Documents or by laws, ordinances, rules,
         regulations or orders of public authorities having jurisdiction shall
         be made at an appropriate time. Unless otherwise provided, the
         Contractor shall make arrangements for such tests, inspections and
         approvals with an independent testing laboratory or entity acceptable
         to the Owner, or with the appropriate public authority, and shall bear
         all related costs of tests, inspections and approvals. The Contractor
         shall give the Architect timely notice of when and where tests and
         inspections are to be made so that the Architect may be present for
         such procedures. The Owner shall bear costs of tests, inspections or
         approvals which do not become requirements until after bids are
         received or negotiations concluded.

         13.5.2   If the Architect, Owner or public authorities having
         jurisdiction determine that portions of the Work require additional
         testing, inspection or approval not included under Subparagraph 13.5.1,
         the Architect will, upon written authorization from the Owner, instruct
         the Contractor to make arrangements for such additional testing,
         inspection or approval by an entity acceptable to the Owner, and the
         Contractor shall give timely notice to the Architect of when and where
         tests and inspections are to be made so that the Architect may be
         present for such procedures. Such costs, except as provided in
         Subparagraph 13.5.3, shall be at the Owner's expense.

         13.5.3   If such procedures for testing, inspection or approval under
         Subparagraphs 13.5.1 and 13.5.2 reveal failure of the portions of the
         Work to comply with requirements established by the Contract Documents,
         all costs made necessary by such failure including those of repeated
         procedures and compensation for the Architect's services and expenses
         shall be at the Contractor's expense.

         13.5.4   Required certificates of testing, inspection or approval
         shall, unless otherwise required by the Contract Documents, be secured
         by the Contractor and promptly delivered to the Owner.

         13.5.5   If the Architect is to observe tests, inspections or approvals
         required by the Contract Documents, the Architect will do so promptly
         and, where practicable, at the normal place of testing.

         13.5.6   Tests or inspections conducted pursuant to the Contract
         Documents shall be made promptly to avoid unreasonable delay in the
         Work.

         13.6     INTEREST

         13.6.1   Payments due and unpaid under the Contract Documents shall
         bear interest from the date payment is due at such rate as the parties
         may agree upon in writing or, in the absence thereof, at the legal rate
         prevailing from time to time at the place where the Project is located.
         Payments due and unpaid for more than 30 days under the Contract
         Documents shall bear interest at the prime rate published from time to
         time in the Wall Street Journal.

         13.7     COMMENCEMENT OF STATUTORY LIMITATION PERIOD

         13.7.1   As between the Owner and Contractor:

                  .1       Before Substantial Completion. As to acts or failures
                           to act occurring prior to the relevant date of
                           Substantial Completion, any applicable statute of
                           limitations shall commence to run and any alleged
                           cause of action shall be deemed to have accrued in
                           any and all events not later than such date of
                           Substantial Completion;

                  .2       Between Substantial Completion and Final Certificate
                           for Payment. As to acts or failures to act occurring
                           subsequent to the relevant date of Substantial
                           Completion and prior to issuance of the final
                           Certificate for Payment, any applicable statute of
                           limitations shall commence to run and any alleged
                           cause of

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below, expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              42

<PAGE>

                           action shall be deemed to have accrued in any and all
                           events not later than the date of issuance of the
                           final Certificate for Payment; and

                  .3       After Final Certificate for Payment. As to acts or
                           failures to act occurring after the relevant date of
                           issuance of the final Certificate for Payment, any
                           applicable statute of limitations shall commence to
                           run and any alleged cause of action shall be deemed
                           to have accrued in any and all events not later than
                           the date of any act or failure to act by the
                           Contractor pursuant to any Warranty provided under
                           Paragraph 3.5, the date of any correction of the Work
                           or failure to correct the Work by the Contractor
                           under Paragraph 12.2, or the date of actual
                           commission of any other act or failure to perform any
                           duty or obligation by the Contractor or Owner,
                           whichever occurs last.

ARTICLE 14 TERMINATION OR SUSPENSION OF THE CONTRACT

         14.1     TERMINATION BY THE CONTRACTOR

         14.1.1   The Contractor may terminate the Contract if the Work is
         stopped for a period of 30 consecutive days through no act or fault of
         the Contractor or a Subcontractor, Sub-subcontractor or their agents
         or employees or any other persons or entities performing portions of
         the Work under direct or indirect contract with the Contractor, for any
         of the following reasons:

                  .1       issuance of an order of a court or other public
                           authority having jurisdiction which requires all Work
                           to be stopped;

                  .2       an act of government, such as a declaration of
                           national emergency which requires all Work to be
                           stopped;

                  .3       because the Architect has not issued a Certificate
                           for Payment and has not notified the Contractor of
                           the reason for withholding certification as provided
                           in Subparagraph 9.4.1, or because the Owner has not
                           made payment on a Certificate for Payment within the
                           time stated in the Contract Documents; or

                  .4       the Owner has failed to furnish to the Contractor
                           promptly, upon the Contractor's request, reasonable
                           evidence as required by Subparagraph 2.2.1.

         14.1.2   The Contractor may terminate the Contract if, through no act
         or fault of the Contractor or a Subcontractor, Sub-subcontractor or
         their agents or employees or any other persons or entities performing
         portions of the Work under direct or indirect contract with the
         Contractor, repeated suspensions, delays or interruptions of the entire
         Work by the Owner as described in Paragraph 14.3 constitute in the
         aggregate more than 100 percent of the total number of days scheduled
         for completion, or 120 days in any 365-day period, whichever is less.

         14.1.3   If one of the reasons described in Subparagraph 14.1.1 or
         14.1.2 exists, the Contractor may, upon seven days' written notice to
         the Owner and Architect, terminate the Contract and recover from the
         Owner payment for Work executed and for proven loss with respect to
         materials, equipment, tools, and construction equipment and machinery,
         including reasonable overhead, profit and damages.

         14.1.4   If the Work is stopped for a period of 60 consecutive days
         through no act or fault of the Contractor or a Subcontractor or their
         agents or employees or any other persons performing portions of the
         Work under contract with the Contractor because the Owner has
         persistently failed to fulfill the Owner's obligations under the
         Contract Documents with respect to matters important to the progress of
         the Work, the Contractor may, upon seven additional days' written
         notice to the Owner and the Architect, terminate the Contract and
         recover from the Owner as provided in Subparagraph 14.1.3.

         14.2     TERMINATION BY THE OWNER FOR CAUSE

         14.2.1   The Owner may terminate the Contract if the Contractor:

                  .1       persistently or repeatedly refuses or fails to supply
                           enough properly skilled workers or proper materials;

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below. expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              43

<PAGE>

                  .2       fails to make payment to Subcontractors for materials
                           or labor in accordance with the respective agreements
                           between the Contractor and the Subcontractors;

                  .3       persistently disregards laws, ordinances, or rules,
                           regulations or orders of a public authority having
                           jurisdiction; or

                  .4       otherwise is guilty of substantial breach of a
                           provision of the Contract Documents.

         14.2.2   When any of the above reasons exist, the Owner, upon
         certification by the Architect that sufficient cause exists to justify
         such action, may without prejudice to any other rights or remedies of
         the Owner and after giving the Contractor and the Contractor's surety,
         if any, seven days' written notice, terminate employment of the
         Contractor and may, subject to any prior rights of the surety:

                  .1       take possession of the site and of all materials,
                  equipment, tools, and construction equipment and machinery
                  thereon owned by the Contractor;

                  .2       accept assignment of subcontracts pursuant to
                  Paragraph 5.4; and

                  .3       finish the Work by whatever reasonable method the
                  Owner may deem expedient. Upon request of the Contractor, the
                  Owner shall furnish to the Contractor a detailed accounting of
                  the costs incurred by the Owner in finishing the Work.

         14.2.3   When the Owner terminates the Contract for one of the reasons
         stated in Subparagraph 14.2.1, the Contractor shall not be entitled to
         receive further payment until the Work is finished.

         14.2.4   If the unpaid balance of the Contract Sum exceeds costs of
         finishing the Work, including compensation for the Architect's services
         and expenses made necessary thereby, and other damages incurred by the
         Owner and not expressly waived, such excess shall be paid to the
         Contractor. If such costs and damages exceed the unpaid balance, the
         Contractor shall pay the difference to the Owner. The amount to be paid
         to the Contractor or Owner, as the case may be, shall be certified by
         the Architect, upon application, and this obligation for payment shall
         survive termination of the Contract.

         14.3     SUSPENSION BY THE OWNER FOR CONVENIENCE

         14.3.1   The Owner may, without cause, order the Contractor in writing
         to suspend, delay or interrupt the Work in whole or in part for such
         period of time as the Owner may determine.

         14.3.2   The Contract Sum and Contract Time shall be adjusted for
         increases in the cost and time caused by suspension, delay or
         interruption as described in Subparagraph 14.3.1. Adjustment of the
         Contract Sum shall include profit. No adjustment shall be made to the
         extent:

                  .1       that performance is, was or would have been so
                           suspended, delayed or interrupted by another cause
                           for which the Contractor is responsible; or

                  .2       that an equitable adjustment is made or denied under
                           another provision of the Contract.

         14.4     TERMINATION BY THE OWNER FOR CONVENIENCE

         14.4.1   The Owner may, at any time, terminate the Contract for the
         Owner's convenience and without cause.

         14.4.2   Upon receipt of written notice from the Owner of such
         termination for the Owner's convenience, the Contractor shall:

                  .1       cease operations as directed by the Owner in the
                           notice;

                  .2       take actions necessary, or that the Owner may direct,
                           for the protection and preservation of the Work; and

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below. expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              44

<PAGE>

                  .3       except for Work directed to be performed prior to the
                           effective date of termination stated in the notice,
                           terminate all existing subcontracts and purchase
                           orders and enter into no further subcontracts and
                           purchase orders.

         14.4.3   In case of such termination for the Owner's convenience, the
         Contractor shall be entitled to receive payment for Work executed, and
         costs incurred by reason of such termination, along with reasonable
         overhead and profit on the Work not executed.

---------
(C) Copyright 1911, 1915, 1918, 1925, 1937, 1951, 1958, 1961, 1963, 1966, 1967,
1970, 1976, 1987, 1997 by The American Institute of Architects. Fifteenth
Edition. Reproduction of the material herein or substantial quotation of its
provisions without written permission of the AIA violates the copyright laws of
the United States and will subject the violate to legal prosecution. WARNING:
Unlicensed photocopying violates U.S. copyright laws and will subject the
violator to legal prosecution. This document was electronically produced with
permission of the AIA and can be reproduced in accordance with your license
without violation until the date of expiration as noted below. expiration as
noted below. User Document: alnylamgc.aia -- 3/1/2004. AIA License Number
1029845, which expires on 12/31/2004.

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES. CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

This document has been approved and endorsed by The Associated General
Contractors of America.

[LOGO]

(C)1997 AIA(R)
AIA DOCUMENT A201 - 1997
GENERAL CONDITIONS OF THE
CONTRACT FOR CONSTRUCTION

The American Institute of Architects
1735 New York Avenue, N.W.
Washington, D.C. 20006-5292

                                                                              45

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