Document:

FORM OF SERIES D WARRANT

 EXHIBIT 4.4 
  

NEITHER THIS WARRANT NOR ANY OF THE SECURITIES ISSUABLE HEREUNDER NOR ANY AMERICAN DEPOSITARY SHARES REPRESENTING THE SECURITIES ISSUABLE HEREUNDER HAVE BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND NONE OF THEM MAY BE OFFERED, SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH
SECURITIES UNDER THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED. 
  
 WARRANT 
 to Purchase             Ordinary Shares of 
 SENETEK PLC

  
 Issued: September 4, 2003 
 Expires: March 4, 2011 
  
 Series D 
 NO. 6 
  
 This Warrant certifies that
                                     or its registered and
permitted successors or assigns (“                ” or the “Holder”), is entitled to, subject to the terms set forth below, purchase from
SENETEK PLC, a corporation organized under the laws of England (the “Company”), from time to time up to                     
(            ) duly authorized, validly issued, fully paid and nonassessable Ordinary Shares (as such number may be adjusted pursuant to Section 4(a) and Section 5 herein) which may
be exchanged for American Depositary Shares (“ADS”) represented by American Depositary Receipts (“ADR”) (the Ordinary Shares of the Company, including any shares into which it may be changed, reclassified, or converted, are
herein referred to as the “Ordinary Shares”). This Warrant is one of the Series D Warrants (the “Warrants”) issued pursuant to Section 3 of the Second Amendment to the Securities Purchase Agreement dated as of September 4, 2003
(the “Second Amendment”), which Second Amendment amends that certain Securities Purchase Agreement, dated as of April 14, 1999, by and between the Company, Silver Creek Investments, Ltd., Bomoseen Investments, Ltd., Dandelion Investments,
Ltd. and Elstree Holdings, Ltd. (as amended, the “Securities Purchase Agreement”). The Ordinary Shares issuable upon exercise of the Warrants (and any other or additional shares, securities or property that may hereafter be issuable upon
exercise of the Warrants) are sometimes referred to herein as the “Warrant Shares,” and the maximum number of shares so issuable under this Warrant is sometimes referred to as the “Aggregate Number” (as such number may be
increased or decreased as more fully set forth herein). 

 This Warrant is subject to the following provisions, terms and conditions: 
  
 Section 1. Exercise of Warrant. 
  
 (a) To exercise this Warrant in whole or in part, the Holder shall deliver
to the Company at its principal office located at 620 Airpark Road, Napa, California 94558, (A) a written notice, in substantially the form of the Exercise Notice attached hereto as Exhibit 1, of the Holder’s election to exercise this
Warrant, which notice shall specify the number of Warrant Shares to be purchased, (B) (i) cash, money order, certified check or wire transfer of immediately available funds payable to the Company, in an amount equal to the Exercise Price (as defined
below) multiplied by the number of Warrant Shares being purchased, or (ii) a copy of an instrument representing outstanding principal amount of indebtedness of the Company owed to the Holder, accompanied by a notice stating the Holder’s
intent to exercise this Warrant, in whole or in part, by the reduction of the amount of indebtedness stated in the notice and represented by the instrument in an amount equal to the Exercise Price multiplied by the number of Warrant Shares being
purchased, and (C) this Warrant. The Company shall as promptly as practicable, and in any event within ten (10) Business Days thereafter, execute and deliver or cause to be executed and delivered, in accordance with such notice, a certificate or
certificates representing the aggregate number of Warrant Shares specified in such notice. The stock certificate or certificates so delivered shall be in such denominations as may be specified in such notice and shall be issued in the name of the
Holder or such other name as shall be designated in such notice. Such certificate or certificates shall be deemed to have been issued and the Holder or any other person so designated to be named therein shall be deemed for all purposes to have
become a Holder of record of such shares immediately prior to the close of business on the date such notice is received by the Company as aforesaid. If this Warrant shall have been exercised only in part, the Company shall, at the time of delivery
of said stock certificate or certificates, deliver to the Holder a new Warrant evidencing the rights of the Holder to purchase the remaining Ordinary Shares called for by this Warrant, which new Warrant shall in all other respects be identical to
this Warrant, or, at the request of the Holder, appropriate notation may be made on this Warrant and the same returned to the Holder. The Company shall pay all expenses, taxes and other charges payable in connection with the preparation, issue and
delivery of such certificates and new Warrants, except that in case such stock certificates or new Warrants shall be registered in a name or names other than the name of the Holder, funds sufficient to pay all stock transfer taxes that are payable
upon the issuance of such stock certificates or new Warrants shall be paid by the Holder at the time of delivering the notice of exercise mentioned above. 
  
 (b) All Ordinary Shares issued upon the exercise of this Warrant shall be validly issued, fully paid and nonassessable and free from all preemptive rights
of any stockholder, and from all taxes, liens and charges with respect to the issue thereof (other than United Kingdom stamp duty taxes and any other transfer taxes) and, if any Ordinary Shares are then listed on a national securities exchange (as
defined in the Securities Exchange Act of 1934, as amended) or quoted on an automated quotation system, shall be listed or quoted thereon, as the case may be, to the extent permissible under the rules of such exchange and not prohibited by law, it
being understood that such listing does not bear upon the transferability of such shares under the Act and the other provisions of this Agreement. 
  

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 (c) The Company shall not be required upon any exercise of this Warrant to issue a certificate
representing any fraction of an Ordinary Share, but, in lieu thereof, shall pay to the Holder cash in an amount equal to a corresponding fraction (calculated to the nearest 1/100 of a share) of the Fair Market Value (as defined below) of one
Ordinary Share on the Business Day immediately prior to the date of receipt by the Company of notice of exercise of this Warrant. 
  
 (d) The Company shall promptly pay all depositary fees payable to the depositary and all stamp duty reserve taxes due to Inland Revenue in respect of the
issuance of American Depositary Shares or American Depositary Receipts in respect of Ordinary Shares issued upon exercise of this Warrant. 
  
 Section 2. Terms and Conditions of Warrants. 
  
 (a) Exercise. Warrants to purchase
                 (as adjusted in accordance with the principles of Section 4(a) or Section 5 hereof) Ordinary Shares shall be exercisable at any time, and from
time to time, on or after the date hereof (the “Exercise Date”), and shall expire at 11:59 p.m., New York City time, on March 4, 2011 (the “Expiration Date”). 
  
 (b) Purchase Price. Subject to the provisions of Sections 5 and 6 hereof, the purchase price per Ordinary Share shall
be $0.40 (the “Exercise Price”). 
  
 (c) Restrictions
on Transfer and Registration Rights. 
  
 (i) Each certificate
for any Warrant Shares issued upon the exercise of this Warrant, and each certificate issued upon the transfer of any such Warrant Shares and each American Depositary Receipt representing American Depositary Shares (except as otherwise permitted by
this Section 2(c)) shall be stamped or otherwise imprinted with a legend in substantially the following form: 
  
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), AND MAY NOT BE
OFFERED, SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED IN THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH SECURITIES UNDER THE ACT AND REGISTRATION OR QUALIFICATION UNDER APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL
REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION AND QUALIFICATION IS NOT REQUIRED. 
  
 (ii) The restrictions imposed by this Section 2(c) upon the transferability of Warrants and Warrant Shares and related American Depositary Shares shall
cease and terminate as to any particular Warrants, Warrant Shares or related American Depositary Shares, (a) when such securities shall have been effectively registered under the Securities Act and disposed of in accordance with the registration
statement covering such securities, or (b) when in the reasonable opinion of counsel 

  

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for the Company such restrictions are no longer required in order to comply with the Securities Act of 1933, as amended (the “Securities Act”).
Whenever such restrictions shall terminate as to any Warrants, Warrant Shares or related American Depositary Shares, the Holder thereof shall be entitled to receive from the Company, without expense, new certificates of like tenor not bearing the
restrictive legend set forth in Section 2(c)(i). 
  
 (d)
Investment Representation. The Holder, by acceptance hereof, represents as of the date hereof, as follows: 
  
 (i) The Warrant Shares issuable upon exercise of the Warrants and any American Depositary Shares issued in respect thereof (collectively, the
“Acquired Securities”) will be acquired for investment for the Holder’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part of the Acquired Securities in contravention of applicable
law, and that the Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. The Holder does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant
participations to such person or to any third person in or with respect to any of the Acquired Securities. 
  
 (ii) The Holder is and upon the acquisition of the Acquired Securities and upon exercise of the Warrants will be an “accredited investor” within
the meaning of Rule 501 of Regulation D of the rules and regulations of the Securities and Exchange Commission under the Securities Act. The Holder has not been organized for the purposes of acquiring the Acquired Securities. 
  
 (iii) The Holder understands that the Acquired Securities it may acquire as
contemplated by this Warrant are “restricted securities” within the meaning of Rule 144 under the Securities Act (“Rule 144”) inasmuch as they will be acquired from the Company in a transaction not involving a public offering and
that under the federal securities laws and applicable regulations such Acquired Securities may be resold without registration under the Securities Act only in certain limited circumstances. In this connection, the Holder represents that it is
familiar with Rule 144 and understands the resale limitations imposed thereby and by the Securities Act. The Holder acknowledges that its investment in the Acquired Securities may be an illiquid investment requiring the Holder to bear the economic
risk of the investment for an indefinite period. 
  
 (iv) Without
in any way limiting the representations set forth in this Section 2(d), the Holder agrees not to make any disposition of all or any portion of the Acquired Securities unless and until the transferee has agreed in writing for the benefit of the
Company to be bound by the terms of this Warrant (provided that such Holder is making such disposition in a transaction other than pursuant to Rule 144 or under an effective registration statement under the Securities Act and in accordance with any
applicable state securities laws), and (A) the Holder shall have notified the Company of the proposed disposition, and (B) if requested by the Company, the Holder shall have furnished the Company with an opinion of counsel, in form and substance
reasonably satisfactory to the Company, rendered by a law firm experienced in matters involving the sale of securities under federal and state securities laws, that such disposition will not require registration of the Acquired Securities under the
Securities Act or registration or qualification under any state securities or “blue sky” law. 
  

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 In the event certificates for Ordinary Shares are delivered upon the exercise of this Warrant, the
Company may cause a legend or legends to be placed on such certificates to make appropriate reference to such foregoing representations and to restrict transfer in the absence of compliance with applicable federal or state securities laws.

  
 Section 3. Transfer, Division and Combination. The Company agrees to
maintain at its offices in Napa, California, books for the registration and transfer of this Warrant and, subject to the provisions of Section 2 hereof, this Warrant and all rights hereunder are transferable, in whole or in part, on such books at
such office, upon surrender of this Warrant at such office, together with a written assignment of this Warrant duly executed by the Holder or his agent or attorney and funds sufficient to pay any stock transfer taxes payable upon the making of such
transfer. Upon such surrender and payment, the Company shall execute and deliver a new Warrant or Warrants in the name of the assignee or assignees and in the denominations specified in such instrument of assignment, and this Warrant shall promptly
be canceled. Notwithstanding the foregoing, a Warrant may be exercised by a new Holder for the purchase of Ordinary Shares without having a new Warrant issued if Holder shall otherwise have complied with the foregoing provisions of this Section 3
and the applicable provisions of Section 2 hereof. All of the provisions of this Section 3 are subject to the provisions of Section 2 above. This Warrant may be divided or combined with other Warrants upon surrender hereof and of any Warrant or
Warrants with which this Warrant is to be combined, together with a written notice specifying the names and denominations in which the new Warrant or Warrants are to be issued, signed by the holders thereof or their respective duly authorized agents
or attorneys. The Company shall execute and deliver a new Warrant or Warrants exchangeable for the Warrant or Warrants to be divided or combined in accordance with such notice. 
  
 Section 4. Successor; Taxes. 
  
 (a) Successor Company. The obligations of the Company under this Warrant shall be binding upon any successor company or organization
resulting from the merger, consolidation or other reorganization of the Company, or upon any successor company or organization succeeding to substantially all of the assets and business of the Company. The Company agrees that it will make
appropriate provision for the preservation of Holder’s rights under this Warrant in any agreement or plan which it may enter into or adopt to effect any such merger, consolidation, reorganization or transfer of assets. 
  
 (b) Taxes on Conversion. The issuance of certificates for Warrant
Shares upon the exercise of this Warrant shall be made without charge to the Holder exercising this Warrant for any issue or stamp tax in respect of the issuance of such certificates, and such certificates shall be issued in the respective names of,
or in such names as may be directed by, the holder; provided, however, that the Company shall not be required to pay any tax that may be payable in respect of any transfer involved in the issuance and delivery of any such certificate
in a name other than that of the Holder, and 

  

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the Company shall not be required to issue or deliver such certificates unless or until the person or persons requesting the issuance thereof shall have paid
to the Company the amount of such tax or shall have established to the satisfaction of the Company that such tax has been paid. 
  
 (c) Withholding Taxes. 
  
 (i) Except to the extent otherwise required by law, the Company will not withhold United States or United Kingdom withholding taxes from payments to be
made to holders of Warrants if such holders (a) are corporations organized under the laws of a jurisdiction outside the United States or United Kingdom or are otherwise persons not resident in the United States or United Kingdom for U.S. federal
income tax purposes or United Kingdom tax purposes, and (b) provide the Company, upon the Company’s reasonable request, with one or more of Internal Revenue Service Form W-8, Form 4224 or other applicable form, certificate or document
prescribed by the Internal Revenue Service of the United States or Inland Revenue of the United Kingdom certifying as to such holders’ entitlement to an exemption from any such withholding requirements. 
  
 (ii) Except to the extent otherwise required by law, the Company will not
withhold United States or United Kingdom withholding taxes from payments to be made to holders of Warrants in excess of an applicable treaty rate if such holders (a) are corporations organized under the laws of a jurisdiction outside the United
States or United Kingdom or are otherwise persons not resident in the United States or United Kingdom for U.S. federal income tax purposes or United Kingdom tax purposes, and (b) provide the Company upon the Company’s reasonable request, with
one or more of certification of their residence address, Internal Revenue Service Form 1001 or other applicable form, certificates or documents certifying as to such holders’ entitlement to a reduced rate of withholding under any such
withholding requirements. 
  
 (iii) Except to the extent otherwise
required by law, neither Section 4(c)(i) nor Section 4(c)(ii) hereof shall require the Company to apply an exemption or reduced rate of withholding during any period when it shall have received notice or has knowledge that (a) the residence or other
information previously provided on any applicable form, certificate or document is incorrect and no corrected form, certificate or document as applicable has been provided to the Company, or (b) of any other information which would render such
exemption or reduced rate inapplicable. 
  
 (iv) Notwithstanding
the preceding Sections 4(c)(i) and 4(c)(ii), if the Company is required by law to withhold from amounts otherwise payable to a holder of Warrants, whether by reason of a change in law or applicable treaty, or because the applicable treaty
withholding rate is greater than zero or by reason of the failure of a holder of Warrants to provide a valid certification or form, the Company shall withhold the amounts required to be withheld. Amounts so withheld with respect to a holder in
accordance with this Section 4 shall be treated as distributed to such holder for all purposes of this Warrant. 
  
 Section 5. Adjustments to Aggregate Number. Subject to Section 7 hereof, the Aggregate Number shall be subject to adjustment from time to time as follows and
thereafter as adjusted shall be deemed to be the Aggregate Number hereunder. 
  

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 (a) Reorganization, Reclassification, Consolidation, Merger or Sale. If any capital reorganization
or reclassification of the Company, or any consolidation or merger of the Company with another person, or the sale, transfer or lease of all or substantially all of its assets to another person shall be effected in such a way that holders of
Ordinary Shares shall be entitled to receive stock, securities or assets with respect to or in exchange for their shares, then provision shall be made, in accordance with this Section 5, whereby the Holder hereof shall thereafter have the right to
purchase and receive, upon the basis and upon the terms and conditions specified in this Warrant and in addition to or in exchange for, as applicable, the Warrant Shares subject to this Warrant immediately theretofore purchasable and receivable upon
the exercise of the rights represented hereby, such securities or assets as would have been issued or payable with respect to or in exchange for the Aggregate Number immediately theretofore purchasable and receivable upon the exercise of the rights
represented hereby if exercise of the Warrant has occurred immediately prior to such reorganization, reclassification, consolidation, merger or sale. The Company will not effect any such consolidation, merger, sale, transfer or lease unless prior to
the consummation thereof the successor entity (if other than the Company) resulting from such consolidation or merger or the entity purchasing or leasing such assets shall assume by written instrument (1) the obligation to deliver to such Holder
such securities or assets as, in accordance with the foregoing provisions, such Holder may be entitled to purchase, and (2) all other obligations of the Company under this Warrant. The provisions of this Section 5(a) shall similarly apply to
successive consolidations, mergers, exchanges, sales, transfers or leases. 
  
 (b) Distributions. If at any time or from time to time the Company shall take a record of the holders of its Ordinary Shares for the purpose of entitling them to receive or pays any dividend or other
distribution to holders of Ordinary Shares (collectively, a “Distribution”) of: 
  
 (i) cash, 
  
 (ii) any evidences of its indebtedness (other than securities convertible into Ordinary Shares (“Convertible Securities”)), any
shares of its capital stock (other than additional Ordinary Shares or Convertible Securities) or any other securities or property of any nature whatsoever (other than cash), or 
  
 (iii) any options or warrants or other rights to subscribe for or purchase any of the following: any
evidences of its indebtedness (other than Convertible Securities), any shares of its capital stock (other than additional Ordinary Shares or Convertible Securities) or any other securities or property of any nature whatsoever, 
  
 then the holder of this Warrant shall be entitled to receive upon the exercise hereof at any
time on or after the taking of such record the number of Ordinary Shares to be received upon exercise of such Warrant determined as stated herein and, in addition and without further payment, the cash, stock, securities, other property, options,
warrants and/or other rights to which such holder or holders would have been entitled by way of the Distribution and subsequent dividends and distributions if such Holder (x) had exercised such Warrants immediately prior to such Distribution, and
(y) had retained the 
  

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 Distribution in respect of the Ordinary Shares and all subsequent dividends and distributions of any nature whatsoever in
respect of any stock or securities paid as dividends and distributions and originating directly or indirectly from such Ordinary Shares. A reclassification of the Ordinary Shares into any other class of stock shall be deemed a distribution by the
Company to the holders of its Ordinary Shares or such shares of such other class of stock within the meaning of paragraph (c) of this Section 5 and, if the outstanding Ordinary Shares shall be changed into a larger or smaller number of Ordinary
Shares as a part of such reclassification, such event shall be deemed a subdivision or combination, as the case may be, of the outstanding Ordinary Shares within the meaning of paragraph (c) of this Section 5. If the securities to be distributed by
the Company involve rights, warrants, options or any other form of Convertible Securities and the right to exercise or convert such securities would expire in accordance with its terms prior to the exercise of this Warrant, then the terms of such
securities shall provide that such exercise or convertibility right shall remain in effect until 30 days after the date the Holder of this Warrant receives such securities pursuant to the exercise hereof. 
  
 (c) In addition to those adjustments set forth in Sections 5(a) and 5(b), but
without duplication of the adjustments to be made under such Sections 5(a) and 5(b) and Section 6, if the Company: 
  
 (i) takes a record of the holders of its Ordinary Shares for the purpose of entitling them to receive or pays a dividend payable in, or
other distribution of, Ordinary Shares; 
  
 (ii)
subdivides its outstanding shares of Ordinary Shares into a greater number of Ordinary Shares; 
  
 (iii) combines its outstanding Ordinary Shares into a lesser number of shares of Ordinary Shares; and/or 
  
 (iv) makes a distribution on its Ordinary Shares in shares
of its capital stock other than Ordinary Shares, 
  
 then (A) the Aggregate Number
in effect immediately prior thereto shall be adjusted so that the holder or holders of this Warrant shall thereafter be entitled to receive, upon exercise hereof, the number of Ordinary Shares or other securities of the Company (such other
securities thereafter enjoying the rights of Warrant Shares under this Warrant) that such Holder would have owned or have been entitled to receive after the occurrence of such event had such Warrants been exercised immediately prior to the
occurrence of such event or the record date with respect thereto, and (B) the Exercise Price shall (until another such event) be adjusted to equal (calculated to the nearest full cent) the quotient derived by dividing (x) the Aggregate Number in
effect immediately prior to such adjustment multiplied by the Exercise Price in effect immediately prior to such adjustment, divided by (y) the Aggregate Number in effect after adjustment pursuant to this Section 5(c). 
  
 Section 6. Adjustment to Exercise Price. 
  
 (a) Subject to Section 7 hereof, if the Company shall issue or sell any
Ordinary Shares at 

  

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a price which is less than the Exercise Price, then the Exercise Price in effect immediately prior thereto shall be adjusted immediately so that the Exercise
Price thereafter shall equal the price per Ordinary Share at which such Ordinary Shares described in this Section 6(a) were issued. The provisions of this paragraph (a) shall not apply to any issuance of additional Ordinary Shares for which an
adjustment is provided under Sections 5(a), (b) or (c). 
  
 (b)
Subject to Section 7 hereof, if the Company shall take a record of the holders of its Ordinary Shares for the purpose of entitling them to receive a distribution of, or shall in any manner issue or sell, any warrants, options or other rights to
subscribe for or purchase (x) any shares of Ordinary Shares or (y) any Convertible Securities, whether or not the rights to subscribe, purchase, exchange or convert thereunder are immediately exercisable, at a purchase price per Ordinary Share which
is less than the Exercise Price, then the Exercise Price in effect immediately prior thereto shall be adjusted immediately so that the Exercise Price thereafter shall equal the consideration for which such Ordinary Shares or Ordinary Shares subject
to Convertible Securities described in this Section 6(b) were issued. For purposes of this Section 6(b), the consideration for any additional Ordinary Shares issuable pursuant to any warrants or other rights to subscribe for or purchase the same or
for any additional Ordinary Shares issuable pursuant to Convertible Securities subject to any warrants or other rights shall be the consideration received or receivable by the Company for issuing such warrants or other rights, plus the additional
consideration payable to the Company upon the exercise of such warrants or other rights and upon the exercise of the Convertible Securities, as the case may be. 
  

(c) If the Company shall take a record of the holders of its Ordinary Shares for the purpose of entitling them to receive a distribution of or shall in
any manner issue or sell Convertible Securities, whether or not the rights to exchange or convert thereunder are immediately exercisable, at a purchase price per Ordinary Share which is less than the Exercise Price, then the Exercise Price in effect
immediately prior thereto shall be adjusted immediately so that the Exercise Price thereafter shall equal the purchase price per Ordinary Share issuable pursuant to the terms of any Convertible Securities. For purposes of this Section 6(c), the
purchase price per Ordinary Share issuable pursuant to the terms of any Convertible Security shall be the consideration received or receivable by the Company for issuing the Convertible Security, plus the additional consideration, if any, payable to
the Company upon the purchase of the Ordinary Share pursuant to the Convertible Security. 
  
 Section 7. General Provisions Regarding Adjustments to Aggregate Number or Exercise Price. 
  
 (a) The following provisions shall be applicable to the making of
adjustments of (i) the Aggregate Number as provided in Section 5 or (ii) the Exercise Price as provided in Section 6: 
  
 (i) The sale or other disposition of any issued Ordinary Shares owned or held by or for the account of the Company shall be deemed an
issuance thereof for the purposes of Sections 5 and 6. 
  
 (ii) The adjustments required by Sections 5 and 6 shall be made whenever and as often as any specified event requiring an adjustment shall occur, except as expressly provided herein. For the purpose of any adjustment, any specified event
shall be deemed to have occurred at the close of business on the date of its occurrence. 

  

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 (iii) In computing adjustments under Sections 5 and 6, fractional interests in Ordinary
Shares shall be taken into account to the nearest one-thousandth (.001) of a share and shall be aggregated until they equal one whole share. 
  
 (iv) If the Company shall take a record of the holders of its Ordinary Shares for an action described in Sections 5 or 6 hereof, but
abandons its plan to take such action prior to effecting such action, then no adjustment shall be required by reason of the taking of such record. 
  
 (v) Notwithstanding anything herein to the contrary, no adjustment shall be made to the Aggregate Number or Exercise Price as a result of
adjustments to the Aggregate Number or Exercise Price as defined in any Warrants issued to the Holder on the date hereof. 
  
 (vi) Upon the expiration or termination of any of the warrants or other rights or options referred to in Section 6(b) above or the
Convertible Securities referred to in Section 6(b) or 6(c) above, the Exercise Price after the expiration or termination of any such warrants, rights, options or Convertible Securities without any exercise or conversion thereof, the issuance of
which caused an adjustment to the Exercise Price, shall be readjusted to such Exercise Price prior to the adjustment made upon the issuance of such warrants, rights, options or Convertible Securities. 
  
 (vii) In case of the issuance at any time of any additional
Ordinary Shares or Convertible Securities in payment or satisfaction of any dividend upon any class of stock other than Ordinary Shares, the Company shall be deemed to have received for such additional Ordinary Shares or Convertible Securities a
consideration equal to the amount of such dividend so paid or satisfied. 
  
 (viii) No adjustment to the Aggregate Number or Exercise Price shall be made for issuances of (A) options to purchase up to 100,000 Ordinary Shares (excluding the options referenced in (D) below) after the date of
this Warrant pursuant to the Company’s No. 1 Executive Share Option Scheme and No. 2 Executive Share Option Scheme or any other employee, non-executive director or consultant share option scheme approved by the Company’s directors, and
Ordinary Shares issuable or issued upon exercise of such options, (B) Ordinary Shares issued or issuable upon (x) the exercise of options, warrants or rights to subscribe for or purchase Ordinary Shares, or (y) the conversion or exchange of
securities convertible into or exchangeable for Ordinary Shares or options, warrants or rights to subscribe for or purchase Ordinary Shares, in each case only to the extent outstanding on the date of issuance of this Warrant, (C) Ordinary Shares
issued pursuant to a transaction described in Section 5(a) or (b) hereof, and (D) options to purchase an aggregate of 525,000 Ordinary Shares that the Company has committed to grant to Brad Holsworth, Andreas O. Tobler and Wade H. Nichols pursuant
to the Company’s No. 1 Executive Share Option Scheme. 
  

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 (ix) No adjustment of the Exercise Price shall be made in an amount less than one cent
per share, provided that any adjustments which are not required to be made by reason of this sentence shall be carried forward and shall be taken into account in any subsequent adjustment made. 
  
 (b) If any event occurs as to which the provisions of Section 5 or Section 6
are not strictly applicable but the lack of any provision for the exercise of the rights of a holder or holders of Warrants would not fairly protect the purchase rights of such holder or holders of Warrants in accordance with the essential intent
and principles of such provisions, then the Company shall appoint a firm of independent certified public accountants in the United States (which may be the regular outside auditors of the Company) of recognized national standing in the United States
satisfactory to the Holder, which shall give its opinion as to the adjustments, if any, necessary to preserve, without dilution, on a basis consistent with the essential intent and principles established in the provisions of Section 5 or Section 6,
the exercise rights of the holders of Warrants. Upon receipt of such opinion, the Company shall forthwith make the adjustments described therein. 
  
 (c) Within 45 days after the end of each fiscal quarter during which an event occurred that resulted in an adjustment pursuant to Section 5 or Section 6,
the Company shall cause to be promptly mailed to each holder of Warrants (and upon the exercise of any Warrants to the exercising holder) by first-class mail, postage prepaid, notice of each adjustment or adjustments to the Aggregate Number or
Exercise Price, as the case may be, effected since the date of the last such notice and a certificate of the Company’s Chief Financial Officer or, in the case of any such notice delivered within 45 days after the end of a fiscal year, a firm of
independent public accountants in the United States selected by the Company and acceptable to a majority in interest of the holders of the Warrants (who may be the regular outside auditors employed by the Company), in each case, setting forth the
Aggregate Number or Exercise Price, as the case may be, after such adjustment, a brief statement of the facts requiring such adjustment and the computation by which such adjustment was made. The fees and expenses of such accountants shall be paid by
the Company. 
  
 Section 8. Covenant to Reserve Shares of Ordinary Shares.
The Company covenants and agrees that it will at all times reserve and set apart and have, free from preemptive rights, a number of shares of authorized but unissued Ordinary Shares sufficient to enable it at any time to fulfill all its obligations
hereunder. The issuance of such shares has been duly and validly authorized, and when issued and sold in accordance with the Warrants, such shares will be duly and validly issued, fully paid and nonassessable. 
  
 Section 9. Intentionally Omitted. 
  
 Section 10. Notices. In the event that: 
  
 (A) the Company proposes to pay any dividend payable in
stock (of any class or classes) or any obligations or stock convertible into or exchangeable for shares of Ordinary Shares upon its Ordinary Shares or make any distribution (other than ordinary cash dividends) to the holders of its Ordinary Shares;

  

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 (B) the Company proposes to grant to the holders of its Ordinary Shares generally any
rights or warrants (excluding any rights or warrants which pursuant to Section 7(a)(viii) hereof would not result in an adjustment of the Aggregate Number or Exercise Price); 
  
 (C) the Company proposes to effect any capital reorganization or reclassification of capital stock of the
Company; 
  
 (D) the Company proposes to
consolidate with, or merge into, any other Company or to transfer its property as an entirety or substantially as an entirety; or 
  
 (E) the Company proposes to effect the liquidation, dissolution or winding up of the Company, 
  
 then the Company shall cause notice of any such intended action to be given to the Holder of
this Warrant not less than 30 days before the date on which the transfer books of the Company shall close or a record shall be taken for such stock dividend, distribution or granting of rights or Warrants, or the date when such capital
reorganization, reclassification, consolidation, merger, transfer, liquidation, dissolution or winding up shall be effective, as the case may be. 
  
 Any notice or other document required or permitted to be given or delivered to the Holder of this Warrant shall be delivered in accordance with Section 15
herein. 
  
 Section 11. Limitation of Liability; Not Shareholders. No
provision of this Warrant shall be construed as conferring upon the Holder the right to vote or to consent or to receive dividends or to receive notice as a shareholder in respect of meetings of shareholders for the election of directors of the
Company or any other matter whatsoever as shareholders of the Company. No provision hereof, in the absence of affirmative action by the Holder to purchase shares of Ordinary Shares, and no mere enumeration herein of the rights or privileges of the
Holder, shall give rise to any liability of Holder for the purchase price or as a shareholder of the Company, whether such liability is asserted by the Company, creditors of the Company or others. 
  
 Section 12. Loss, Destruction of Warrant. Upon receipt of evidence satisfactory to the
Company of the loss, theft, mutilation or destruction of this Warrant, and in the case of any such loss, theft or destruction upon delivery of a bond of indemnity in such form and amount as shall be reasonably satisfactory to the Company (the
original Warrant holder’s indemnity being satisfactory indemnity in the event of loss, theft or destruction of any Warrant owned by such holder), or in the event of such mutilation upon surrender and cancellation of this Warrant, the Company
will make and deliver a new Warrant, of like tenor and representing the right to purchase the same Aggregate Number of Ordinary Shares, as adjusted in Section 5, as provided for in such lost, stolen, destroyed or mutilated Warrant, in lieu of such
lost, stolen, destroyed or mutilated Warrant. Any Warrant issued under the provisions of this Section 12 in lieu of any Warrant alleged to be lost, destroyed or stolen, or of any mutilated Warrant, shall constitute an original contractual obligation
on the part of the Company. 
  

 12 

 Section 13. Amendments. Neither this Warrant nor any term hereof may be changed, waived, discharged or terminated
orally or in writing, provided that any term of this Warrant may be amended or the observance of such term may be waived (either generally or in a particular instance and either retroactively or prospectively) with, but only with, the written
consent of the Company and the Holders of the Warrants that are exercisable for a number of Ordinary Shares that represent in the aggregate at least a majority of the total number of Ordinary Shares for which all of the Warrants are then exercisable
(whether or not the Holder of this Warrant consents). 
  
 Section 14.
Severability. If in any jurisdiction, any provision of this Agreement or its application to any party or circumstance is restricted, prohibited or unenforceable, such provision shall, as to such jurisdiction, be ineffective only to the extent
of such restriction, prohibition or unenforceability without invalidating the remaining provisions hereof and without affecting the validity or enforceability of such provision in any other jurisdiction or its application to other parties or
circumstances. 
  
 Section 15. Notice. Any notice or document required or
permitted by this Agreement to be given to a party hereto shall be in writing and is sufficiently given if delivered personally, or if sent by prepaid certified mail, return receipt requested, to such party addressed as follows: 
  

	 (i)
	  	If to the Company:	  	Senetek PLC
	 	  	 	  	620 Airpark Road
	 	  	 	  	Napa, California 94558
	 	  	 	  	Attention: Chairman and CEO
			
	 	  	copy to:	  	Coudert Brothers LLP
	 	  	 	  	1114 Avenue of the Americas
	 	  	 	  	New York, New York 10036
	 	  	 	  	Attention: Anthony Williams, Esq.
			
	 (ii)
	  	If to the Holder:	  	c/o Robert T. Tucker, Esq.
	 	  	 	  	61 Purchase Street, Suite 2
	 	  	 	  	Rye, New York 10580
			
	 	  	copy to:	  	Pryor Cashman Sherman & Flynn LLP
	 	  	 	  	410 Park Avenue
	 	  	 	  	New York, New York 10022
	 	  	 	  	Attention: Selig D. Sacks, Esq.

  
 Notice so mailed shall be deemed to
have been given upon receipt if delivered personally or on the fifth business day next following the date of the returned receipt. Any notice delivered to the party to whom it is addressed shall be deemed to have been given and received on the day
it is delivered. Any party may from time to time notify the others in the manner provided herein of any change of address which thereafter, until changed by like notice, shall be the address of such party for all purposes hereof. 
  

 13 

 Section 16. Governing Law; Choice Of Forum; Certain Consents; Waiver Of Jury Trial,
Counterclaim, Setoff. 
  
 THIS WARRANT SHALL BE DEEMED TO HAVE BEEN MADE IN
NEW YORK, NEW YORK. THIS WARRANT AND THE RIGHTS GRANTED HEREIN SHALL BE GOVERNED BY AND CONSTRUED AND ENFORCED UNDER THE LAWS OF THE STATE OF NEW YORK (WITHOUT GIVING EFFECT TO ANY OF SUCH STATE’S CONFLICT OF LAWS RULES OR PRINCIPLES, OTHER
THAN SECTIONS 5-1401 AND 5-1402 OF THE NEW YORK GENERAL OBLIGATIONS LAW). ANY JUDICIAL PROCEEDING BROUGHT BY OR AGAINST THE COMPANY WITH RESPECT TO THIS WARRANT OR ANY RELATED WARRANT SHALL BE BROUGHT IN ANY COURT OF COMPETENT JURISDICTION IN THE
UNITED STATES OF AMERICA IN THE SOUTHERN DISTRICT OF NEW YORK, AND, BY EXECUTION AND DELIVERY OF THIS WARRANT, THE COMPANY ACCEPTS THE EXCLUSIVE JURISDICTION OF THE AFORESAID COURTS AND IRREVOCABLY AGREES TO BE BOUND BY ANY JUDGMENT RENDERED THEREBY
IN CONNECTION WITH THIS WARRANT. IF ANY ACTION IS COMMENCED IN ANY OTHER JURISDICTION, THE PARTIES HERETO HEREBY CONSENT TO THE REMOVAL OF SUCH ACTION TO THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK. THE COMPANY HEREBY
DESIGNATES COUDERT BROTHERS LLP-NEW YORK AS THE DESIGNEE, APPOINTEE AND AGENT OF THE COMPANY TO RECEIVE, FOR AND ON BEHALF OF THE COMPANY, SERVICE OF PROCESS IN THE ABOVE DESCRIBED JURISDICTION IN ANY LEGAL ACTION OR PROCEEDING WITH RESPECT TO THIS
WARRANT OR THE RIGHTS AND OBLIGATIONS HEREUNDER AND SUCH SERVICE SHALL BE DEEMED COMPLETED UPON DELIVERY THEREOF TO SUCH AGENT. IT IS UNDERSTOOD THAT A COPY OF SUCH PROCESS SERVED ON SUCH AGENT WILL BE PROMPTLY FORWARDED BY MAIL TO THE COMPANY AT
ITS ADDRESS SET FORTH IN SECTION 15 HEREOF, BUT THE FAILURE OF THE COMPANY TO RECEIVE SUCH COPY SHALL NOT AFFECT IN ANY WAY THE SERVICE OF SUCH PROCESS. THE COMPANY FURTHER IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS OUT OF ANY OF THE
AFOREMENTIONED COURTS IN ANY SUCH ACTION OR PROCEEDING BY THE MAILING OF COPIES THEREOF BY REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO THE COMPANY AT ITS ADDRESS, SUCH SERVICE TO BECOME EFFECTIVE 10 DAYS AFTER SUCH MAILING. NOTHING HEREIN
SHALL AFFECT THE RIGHT OF THE HOLDERS OF ANY OF THE WARRANTS OR WARRANT SHARES TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED BY LAW. THE COMPANY WAIVES IN EACH SUCH ACTION AND OTHER LEGAL PROCEEDING THE RIGHT TO TRIAL BY JURY AND THE RIGHT TO
ASSERT ANY COUNTERCLAIM OR SETOFF. 
  

 14 

 [signature page follows; remainder of page left intentionally blank] 
  

 15 

 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed in its name by its duly
authorized officer. 
  
 Dated: September 4, 2003

  
  

	 SENETEK PLC

		
	 By:
	 	  

	 	 	 Name:
	 	Wade H. Nichols
	 	 	 Title:
	 	 Executive Vice President,
 Corporate
Development

  

 16 

 Exhibit 1 
  

EXERCISE NOTICE 
  
 The undersigned Holder hereby elects to exercise purchase rights represented by such Warrant for, and to purchase thereunder
             Ordinary Shares covered by such Warrant and herewith makes payment in full therefor of $            
cash and/or by cancellation of $             of indebtedness of the Company to the Holder hereof and requests that, subject to the terms and conditions of the Warrant, certificates
for such shares (and any securities or property deliverable upon such exercise) be issued in the name of and delivered to              whose address is
                                        
        , and whose social security or employer identification number is                     .

  
 The undersigned agrees that, in the absence of an effective
registration statement with respect to Ordinary Shares issued upon this exercise, the undersigned is acquiring such Ordinary Shares for the Holder’s own account and not as a nominee for any other party, for investment and not with a view to
distribution thereof and that the certificate or certificates representing such Ordinary Shares may bear a legend substantially as follows: 
  
 THESE SHARES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, ASSIGNED OR HYPOTHECATED IN
THE ABSENCE OF A REGISTRATION STATEMENT IN EFFECT WITH RESPECT TO SUCH SECURITIES UNDER THE ACT AND APPLICABLE STATE SECURITIES LAW OR AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED. 

 
 In addition, the undersigned agrees that, in the absence of an effective
registration statement with respect to Ordinary Shares issued upon this exercise, stop transfer instructions will be entered on the Company’s stock transfer records with respect to Ordinary Shares issued upon this exercise. 
  

	 Dated:
	  	  

	 	  	Signature guaranteed:

 FORM OF ASSIGNMENT 
  
 FOR VALUE RECEIVED the undersigned registered Holder of the within Warrant hereby sells, assigns, and transfers unto the
Assignee(s) named below (including the undersigned with respect to any Warrants constituting a part of the Warrants evidenced by the within Warrant not being assigned hereby) all of the right of the undersigned under the within Warrant, with respect
to the number of Warrants set forth below: 
  

	 Name of Assignees

	 	 Address

	 	 Social security or other
identifying number of
Assignee(s)

	  	Number of Warrants

  
 and does hereby irrevocably constitute
and appoint                              the undersigned’s attorney to make such transfer
on the books of                              maintained for that purpose, with full power of
substitution in the premises. 
  
 Dated:
                     
  

	                                    
 (1)

	 (Signature of Owner)

	
	 (Street Address)

	
	 (City) (State) (Zip Code)

	(1)	The signature must correspond with the name as written upon the face of the within Warrant in every particular, without alteration or enlargement or any change whatsoever.

  

 18LICENSE AGREEMENT DATED AUGUST 1, 2003

 EXHIBIT 10.1 
  
 LICENSE AGREEMENT 
  
 This License Agreement (this “Agreement”) is made and entered into as of August 1, 2003, by and between Senetek PLC, an English corporation with
its corporate headquarters located at 620 Airpark Road, Napa, California 94558 (“Senetek”), and ICN Pharmaceuticals, Inc., a Delaware corporation with its corporate headquarters located at 3300 Hyland Avenue, Costa Mesa, California
92626 (“Licensee”). 
  
 BACKGROUND

  

	 	A.	Senetek has developed and holds certain patents and other proprietary intellectual property and other rights relating to the use as a skin care or cosmetic product of formulations
containing Kinetin. 

  

	 	B.	Licensee is a leading manufacturer and distributor of a broad range of pharmaceutical products worldwide. 

  

	 	C.	Senetek’s wholly-owned subsidiary Carme Cosmeceutical Science Inc. (“Carme”) and Licensee are parties to a Distribution Agreement made as of October 23, 1998, as
amended, pursuant to which Licensee distributes under license from Carme a line of Kinetin-containing dermatological creams and lotions under Licensee’s “Kinerase” trademark. 

  

	 	D.	Senetek and Licensee desire to enter into a new license for Licensee to manufacture and distribute Licensee Products and distribute Senetek Products (both as
hereinafter defined) worldwide, and Carme is willing to terminate the existing Distribution Agreement. 

  
 Accordingly, in consideration of the mutual promises, covenants, and conditions set forth below, the parties agree as follows: 
  
 1. DEFINITIONS 
  
 When used in this Agreement, each of the following capitalized terms shall have the respective meanings set forth in this
Article. 
  
 1.1 “Affiliate”
means any corporation, partnership, proprietorship or other legal entity directly or indirectly controlled by, controlling, or under common control with another legal entity, “control” meaning, for purposes hereof, the effective
power to elect at least a majority of the Board or Directors or other management body of a legal entity or to effectively direct the management of a legal entity, by the ownership of voting securities, by contract, or otherwise. 

 1.2 “Agreement Date” means the date of this Agreement first set forth
above. 
  
 1.3 “Authorized Channel”
means collectively the “Ethical Channel,” comprised of the sale of products into the ethical market channel, including physicians, pharmacies, medical clinics and HMO’s and other recognized prescription drug channels, the
“Internet Channel,” comprised of direct-to-consumer promotion over interactive internet web sites and telemarketing in support thereof, and the “Direct to Consumer Channel”, comprised of direct-to-consumer
promotions and/or sales by means other than the Internet Channel. 
  
 1.4 “Base Price” means, with respect to the Senetek Product listed on Schedule 1.4, the price per Unit set forth in Schedule 1.4, with respect to the Licensee Products listed on Schedule 1.19, the
price per Unit set forth in Schedule 1.19 to be applicable if Senetek manufactures any Licensee Products during a Disruption Period, and with respect to any other Products added to this Agreement in accordance with its terms, such price per Unit as
the parties shall mutually agree upon, subject in all cases to amendment of the Base Price of each sku as of the end of each Contract Year to reflect changes in direct costs pursuant to Section 3.2(ii). 
  
 1.5 “Best Efforts” means that commercially
reasonable degree of effort, expertise, knowledge and resources which one skilled, able, familiar with and experienced in the matters set forth herein would utilize and otherwise apply with respect to fulfilling a like obligation subject to existing
legal, contractual and other restrictions. 
  
 1.6 “Calendar Quarter” means a period beginning on the first day of January, April, July and October and ending on the last day of March, June, September and December, respectively, provided that the first Calendar
Quarter means the period beginning on the Agreement Date and ending on the last day of September, 2003. 
  
 1.7 “Confidential Information” means marketing, sales, financial, scientific, and other non-public and/or proprietary
information concerning the products, projects, businesses and operations of a party or its Affiliates disclosed by such party to the other party or its Affiliates or of which the other party or its Affiliates gains knowledge in performing this
Agreement. 
  
 1.8 “Contract
Year” means a period beginning on any August 1 during the Term and ending on the first to occur of July 31 of the succeeding calendar year or the termination of this Agreement. 
  
 1.9 “Disruption Period” means any period during which Senetek Product or Licensee Product
is unable to be manufactured in conformance with the Specifications as provided in Section 3.6, with the effect set forth in Section 3.7. 
  
 1.10 “Documentation” means the documentation relating to the Patents and Know-How identified in Schedule 1.10.

  

 2 

 1.11 “Final Adjudication” means any decision by a Governmental Entity of
competent jurisdiction if either (a) any and all appeals (including to other Governmental Entities of competent jurisdiction) in connection with the adjudication are exhausted or (b) the time for any such appeal shall have passed without such appeal
having been perfected. 
  
 1.12
“Government Entity” means any competent governmental agency, board, authority, commission, court or other governmental entity having lawful jurisdiction. 
  
 1.13 “Intellectual Property” means collectively the Patents, the Know-How and all common
law and statutory trademarks, trade names, copyrights, designs and other proprietary rights related to or useful in the performance of this Agreement that Senetek owns or has rights to on the Agreement Date, and all patents, Know-How and common law
and statutory trademarks, trade names, copyrights, designs and other proprietary rights related to or useful in the performance of this Agreement that Senetek acquires rights to after the Agreement Date except any as to which Senetek or an
Affiliate, having used Best Efforts, is unable to obtain the right to make the same available to Licensee, provided, however, that Intellectual Property shall not include patents, Know-How or other rights to the extent the same relate to
Zeatin or any other analog of Kinetin, which shall be the subject of Licensee’s right of first offer pursuant to Section 2.3. 
  
 1.14 “Know-How” means all special knowledge, trade secrets and technical or other proprietary information, whether or not
patented or patentable, related to or useful in the performance of this Agreement that Senetek owns or has rights to on the Agreement Date, and all special knowledge, trade secrets and technical or other proprietary information related to or useful
in the performance of this Agreement that Senetek acquires right to after the Agreement Date except any as to which Senetek or an Affiliate, having used Best Efforts, is unable to obtain the right to make the same available to the Licensee,
provided, however, that Know-How shall not include any such special knowledge, trade secrets or technical or other proprietary information to the extent the same relates to Zeatin or any other analog of Kinetin, which shall be the subject of
Licensee’s right of first offer pursuant to Section 2.3. 
  
 1.15 “Minimum Payments” means the minimum amount of royalties and Base Price payable to Senetek during each Contract Year in order to maintain the Exclusivity Right, as specified in Section 3.12.

  
 1.16 “Net Sales” means the
gross amount billed for Products sold or otherwise distributed to any party by Licensee, its Affiliates or its sub-licensees (not including sales or other distribution by Licensee to its Affiliates or sub-licensees), less the following deductions to
the extent consistent with Licensee’s standard trade terms for like products and with GAAP): 
  
 (i) Trade, quantity or cash discounts applicable to gross amounts billed and allowed, paid or otherwise included in determining net sales;

  
 (ii) Credit or allowance, if any, given or
made on account of returns (supported by appropriate documentation) of Products previously delivered; and 
  

 3 

 (iii) Charge back payments and rebates granted to managed health care
organizations or to national, federal, state or local governments, their agencies or reimbursers, or to trade customers, including but not limited to wholesalers and chain and pharmacy buying groups. 
  
 Net Sales shall not include any pass through costs invoiced
to customers as separate items for freight or shipping insurance. For all purposes of this Agreement, “GAAP” shall mean Unites States generally accepted accounting principles consistently applied by Licensee in preparing its audited
consolidated financial statements. 
  
 1.17
“Patents” means the patents for Kinetin set forth on Schedule 1.17 and any after-acquired patents included in the Intellectual Property. 
  
 1.18 “Person” shall be broadly construed to include any governmental entity, legal entity or individual. 
  
 1.19 “Products” means the Senetek Product
set forth in Schedule 1.4 and the initial eleven (11) sku’s of Licensee Products set forth in Schedule 1.19, together with such other products for topical application containing Kinetin as Licensee desires to add which achieve permeation test
(or other test if the parties agree) results pursuant to Section 3.8 substantially as good as or better than the results achieved by the Products listed in Schedules 1.4 and 1.19, but excluding any product subject to regulation as a prescription
drug. 
  
 1.20 “Royalty” means
the royalty on Net Sales of Products provided for in Section 3.12. 
  
 1.21 “Specifications” means the specifications for the initial Products set forth in Schedules 1.4 and 1.19 and the specifications for each other Product added after the Agreement Date as provided in
Section 1.19. 
  
 1.22
“Territory” means the Core Territory, comprised of Canada and the United States of America, and, subject to Section 3.13, the European Union as constituted on the Agreement Date and Australia, and the Non-Exclusive
Territory, comprised of all countries other than those comprising the Core Territory. 
  
 1.23 “Term” means the period starting on the Agreement Date and ending (if not earlier terminated pursuant to the other
terms of this Agreement) upon the expiration of the last to expire of the Patents issued in the United States containing a Valid Claim. 
  
 1.24 “Trial Size” means a Unit that is a sampling vehicle with a fill weight that is less than thirty percent (30%) of
the fill weight of the regular business Product and that is given to customers or end-use consumers free of charge or at or below cost with the objective of generating trial and awareness of Products. 
  
 1.25 “Unit” means an individual packaged
unit of Product. 
  

 4 

 1.26 “Valid Claim” means any claim in an unexpired patent or patent
application included within the Patents that has not been disclaimed or held invalid or unenforceable by a Governmental Entity of competent jurisdiction in a Final Adjudication. 
  
 2. LICENSE 
  
 2.1 Grant of License. Senetek hereby grants to Licensee during the Term an exclusive license in the Core Territory (except as
respects the Direct to Consumer Channel, which shall be non-exclusive) and a non-exclusive license in the Non-Exclusive Territory under the Intellectual Property to (i) market and sell the Senetek Products and (ii) manufacture, package, market and
sell the Licensee Products, in each case only into the Authorized Channel, and the right to use the Documentation and Senetek’s Confidential Information to facilitate such manufacture, packaging, marketing and sale, in each case subject to the
terms of this Agreement. 
  
 2.2 Exclusivity.
Senetek agrees that, for so long during the Term as Licensee makes the Minimum Payments, (i) Senetek shall not grant a license to any third party to manufacture or sell any non-prescription product for topical application containing a
concentration of Kinetin of 0.1% or higher, provided that Licensee acknowledges that Lavipharm S.A. has heretofore been granted rights to make and sell products containing 0.1% concentration of Kinetin, (ii) Senetek and its Affiliates will
not sell and will not grant to any third party rights to make, have made or sell non-pharmaceutical dermatological products containing Kinetin in the Ethical Channel in the Core Territory, provided that Licensee acknowledges that Vivier
Pharma Inc. has heretofore been granted rights to make and sell products containing Kinetin in the Ethical Channel in Canada and the United States of America (Senetek warranting hereby that Vivier Pharma Inc. can sell or seek a United States
marketing and/or distribution partner for the Vitamin C Serum with 0.025% Kinetin, and all other Kinetin-containing products may only be marketed, sold and distributed by Vivier Pharma Inc. through its order fulfillment houses, wholesalers and
pharmacies), and (iii) Senetek and its Affiliates will not grant to any third party rights to sell non-pharmaceutical dermatological products containing Kinetin in the Internet Channel in the Core Territory, provided that Licensee
acknowledges that various of the existing license agreements between Senetek and third parties expressly or by implication grant such licensees the right to sell licensed products in the Internet Channel, that Senetek intends to sell its own branded
line of Kinetin-containing products direct to consumers through, among other media, the Internet Channel and Direct to Consumer Channel (infomercials and related telemarketing and print), and that Senetek undertakes no obligation hereunder to
enforce the exclusivity granted by this clause (iii) (collectively, the “Exclusivity Right”). Notwithstanding anything to the contrary set forth in Section 2.1 above or in this Section 2.2, except for sales by Senetek as above-described,
Senetek will not, and will not grant the right to any third party to, sell Products during the first Contract Year through the Direct to Consumer Channel. Thereafter, in the event Senetek sells or grants any third party the right to sell Products
through the Direct to Consumer Channel, such action will be one of the factors considered in the next negotiation for adjustment of Minimum Payments. Senetek’s sole remedy if Licensee fails to make the Minimum Payments for any Contract Year
shall be to terminate the Exclusivity Right, unless Licensee shall cure such failure as provided in Section 9.2. 
  

 5 

 2.3 Right of First Offer. During the Term, Licensee shall have the right of first
offer to obtain the right to sell in the Authorized Channel in the Territory new and enhanced products developed or otherwise acquired by Senetek or its Affiliates which utilize Kinetin analogs, including Zeatin, as the primary active ingredient for
use as a skin care product, provided that such right of first offer shall not apply with regard to products that are protected through patents or other exclusivity as to, owned by, or vested in a third party and as to which Senetek or its
Affiliates have not acquired the right to grant marketing rights to others. At such time as Senetek determines, based on preliminary in vitro or other studies, that such an analog exhibits action that may make it commercially marketable,
Senetek shall give Notice to Licensee together with all preliminary study data in Senetek’s possession or control. Licensee shall have sixty (60) days from the date that Senetek notifies Licensee that such a new or enhanced product is to or may
become available for sale to deliver an offer to Senetek setting forth in reasonable detail the terms upon which Licensee would purchase, market and resell such product. If Senetek elects not to accept Licensee’s offer (or if no offer is made
within such period), Senetek shall be free to grant such rights to others on terms no better to such other party than those last offered by Licensee (or, if Senetek has made a counter offer, on terms no better to such other party than those offered
by Senetek to Licensee), to exercise such rights itself, or any combination thereof, all in Senetek’s sole and absolute discretion; provided, however, that in connection with entering into a definitive agreement with such other party,
Senetek provides to such other party preliminary study data no different than the study data provided to Licensee. If Senetek develops or gains rights to study data with respect to such analog different than the study data made available to
Licensee, it shall give a further Notice to Licensee together with such different study data and Licensee shall have sixty (60) days from the date of Senetek’s further Notice to deliver an offer to Senetek as above set forth (it being the
parties’ intention that such procedure shall be repeated until such time as the studies developed by or for Senetek demonstrate “proof of concept” of such analogue). 
  
 2.4 No Other Rights. It is expressly understood that this Agreement grants no rights to Licensee
except those express rights set forth in this Article 2. Without limiting the foregoing, it is understood and agreed that Licensee has no right pursuant to this Agreement to, and shall not, (i) sell or knowingly permit its customers to re-sell any
Products other than into the Authorized Channel within the Territory to the extent it is legally permissible to prohibit or restrict such activity, (ii) manufacture or have manufactured Senetek Products otherwise than during a Disruption Period,
(iii) manufacture, have manufactured, use or sell Products otherwise than pursuant to the terms of this Agreement, or (iv) acquire or assert any co-ownership or other proprietary interest in any of the Intellectual Property by virtue of its
manufacture, packaging, marketing or sale of Products. Upon any termination of this Agreement, Licensee shall have no right of any kind with respect to the Products or the Intellectual Property, Know-How, Documentation or Senetek Confidential
Information other than the right to complete the sale of Senetek Product then lawfully in its possession and Licensee Product that is work in process on the date of termination, provided that Licensee pays all amounts due with respect
thereto. Except as expressly provided in this Agreement, including Section 3.7, nothing in this Agreement shall diminish Licensee’s rights in any patent, trademark or other intellectual property that it may have or develop during the Term of
this Agreement or the Distribution Agreement between Licensee and Carme dated October 23, 1998, provided, that if Licensee develops during the Term of this Agreement any patent for a Product specifically for the amelioration of the effects of
aging not in combination with any proprietary ingredient used in Licensee products, Licensee shall negotiate in good faith with Senetek for a non-exclusive license for Senetek to practice such patent outside of the Ethical Channel.. 
  

 6 

 3. MANUFACTURE, PURCHASE AND SALE OF PRODUCTS 
  
 3.1 Payment for Senetek Products. 
  
 (i) Senetek shall invoice Licensee for the full Base Price of Senetek Products ordered by Licensee (plus
freight and insurance if Licensee so requests) at the time of each shipment. Licensee shall accept or reject such shipment within twenty (20) days of receipt. Licensee shall pay Senetek the full amount invoiced within fifteen (15) days after
Licensee’s acceptance of such shipment. Payments more than thirty (30) days past due shall be subject to a handling fee of the lesser of one percent (1%) per month or the maximum amount allowed by law from the date payment was due. Payments of
Base Price shall not be subject to any offset for any claim Licensee may have against Senetek other than a claim based upon the specific shipment unless and until such claim is approved by Senetek in writing or is determined to be valid in a Final
Adjudication. 
  
 (ii) At the end of each
Contract Year, the Base Price of all Products for which a Specification then exists shall be adjusted to reflect any increases or decreases in the direct costs of producing each Product since the Base Price of such Product was set or last adjusted.

  
 3.2 Sourcing of Senetek Products.
Senetek Products shall be manufactured by such contract manufacturer or contract manufacturers as Senetek may from time to time designate. Licensee shall have the right, on prior notice, to visit and conduct reasonable audits of the
manufacturing sites at which Senetek Products are produced. Senetek Products shall be manufactured in accordance with the same standards as are applicable to Licensee Products under Section 3.9. Any manufacturing site transfer shall be performed in
accordance with standards of good manufacturing practices for cosmetic products. 
  
 3.3 Orders for Senetek Products. All orders for Senetek Products shall be delivered to Senetek at its address first set forth above
or at such other address as Senetek may specify by written Notice in accordance with the requirement of this Agreement, to the Attention of the Purchasing Department. 
  
 3.4 Forecasts of Senetek Product Purchases. Licensee shall provide Senetek with a rolling twelve (12)
month forecast of its requirements for Senetek Products, to be updated quarterly and delivered to Senetek at least thirty (30) days in advance of the period forecasted. The first three (3) months of each such forecast shall be firm. 
  
 3.5 Delivery of Senetek Products. All shipments of
Senetek Products shall be FOB Senetek’s point of shipment and all risk of loss or damage shall pass to Licensee at that point. If Senetek arranges for shipping and insurance it shall add the costs to the invoice. Senetek shall use its Best
Efforts to fulfill orders within ninety (90) days of the date they are received. 
  

 7 

 3.6 Disruption Periods. If following receipt of any order Senetek determines that,
due to circumstances beyond Senetek’s reasonable control, Senetek does not expect to be able to fulfill the order in full within such ninety (90) day period, Senetek shall give prompt Notice to Licensee of such expected inability. The period
from the date any such Notice is given, or in the event no such Notice is given, the date from which Senetek fails to fulfill any order within such ninety (90) day period, until the date of a further Notice from Senetek that it is able to
immediately resume fulfilling orders within such ninety (90) day period, shall be deemed a “Disruption Period”. If at any time Licensee does not expect to be able to manufacture any Licensee Product within ninety (90) days after its
order is placed, Licensee shall give prompt Notice to Senetek of such expected inability. The period from the date any such Notice is given, or in the event no such notice is given, the date from which Licensee is unable to manufacture any Licensee
Product within ninety days from the time it would have placed an order, until the date of a further Notice from Licensee that it is able to immediately resume obtaining such Licensee Product, shall similarly be deemed a “Disruption
Period”.  
  
 3.7 Interim
Manufacturing License. During any Disruption Period, the party whose manufacturing is disrupted shall use its Best Efforts to transfer to the other party (or a contract manufacturer designated by the other party) the disrupted manufacturing
operation(s) (or if such party believes that, despite its Best Efforts, it will be unable to so transfer the disrupted manufacturing operations, it shall use Best Efforts to assure that the manufacturer has qualified a back-up manufacturer to which
such operations can be transferred during any Disruption Period ( a “Back-Up Manufacturer”)), and each party hereby grants a non-exclusive license to use the Intellectual Property to produce the Products and agrees to assist the other
party in taking over manufacturing by providing such manufacturing records, recipes and other Confidential Information as may reasonably be required by them for such purpose (or in assuring an orderly transfer of manufacturing to a Back-Up
Manufacturer). All manufacturing of the Products pursuant to such interim license shall be performed in accordance with the Specifications, all applicable cosmetic good manufacturing practices requirements, and all requirements of law. Each party
shall provide such packaging and labeling and other materials held in its inventory as shall be required, upon payment of its actual cost of producing or purchasing such materials and shipping the same to the designated address therefor. The interim
license granted by this Section 3.7 shall terminate automatically at the end of the Disruption Period, and neither party nor any permitted contract manufacturer shall be deemed to have acquired any ongoing rights by reason of such interim license.
Each party and permitted contract manufacturer shall return to the furnishing party, at the end of the Disruption Period, any and all Confidential Information that may have been provided in order to facilitate such interim manufacture.
Notwithstanding the foregoing, in the event of two (2) or more Disruption Periods affecting a party within any twenty-four (24) month period, the interim license granted by this Section 3.7 shall become permanent. To avoid a disruption during any
Disruption Period, each party shall use Best Efforts to permit the other party at any time during the Term of the Agreement to perform technology transfer, manufacturing scale up and manufacturing development for the Products at a site of the other
party’s choosing, or to inspect and audit its manufacturers’ Back-Up Manufacturer’s facilities, if applicable. 
  
 3.8 Formulation Testing of Products. If during the Term Licensee desires to add a new or modified Product, Licensee shall submit to
Dr. Gerald McCullough, Department of Dermatology, University of California at Irvine (“UCI”), or a commercial or academic facility 

  

 8 

 
having capabilities comparable to those of UCI, samples of each new or modified formulation to conduct skin permeation testing following the methodologies
developed at UCI for the use of radio isotope labeled Kinetin compound or methodologies developed at such other facility which will produce test results substantially similar to those at UCI, provided, that if Licensee identifies and
demonstrates testing methodologies other than permeation testing that will gauge the efficacy of Kinetin in topical formulations as effectively as permeation testing, Senetek will give consideration thereto. Licensee shall bear the expenses of all
such testing, including the cost of UCI in obtaining radioisotope labeled Kinetin for use in such tests. Licensee agrees that no new or modified formulation for which permeation test (or such other test) results substantially as good as or better
than those of the Products listed in Schedules 1.4 and 1.19 are not so obtained shall be used for Licensee Product. If Licensee proposes to conduct other studies of any such new or modified formulation containing Kinetin, Licensee shall give Notice
to Senetek describing such studies and shall obtain Senetek’s approval thereof, such approval not to be unreasonably withheld or delayed. Licensee agrees to pay or reimburse Senetek for any developmental and testing expenses incurred by it for
new or modified Products requested by Licensee. 
  
 3.9 Licensee Product Manufacturing. Licensee shall use Best Efforts to assume manufacturing, packaging and labeling of all Licensee Products within commercially reasonable periods, provided that, as respects the Licensee
Product listed as Number 11 in Schedule 1.19, Grant Industries shall retain bulk manufacturing and ship such bulk Product to Licensee for packaging and labeling. All Licensee Products shall be manufactured in full compliance with all applicable
cosmetic good manufacturing practices requirements and all requirements of law. Any manufacturing site transfer shall be performed in accordance with standards of good manufacturing practices for cosmetic products. If Licensee desires to purchase
its supplies of Kinetin from a source other than Senetek’s current authorized vendor, it shall obtain Senetek’s prior approval of such new vendor, which approval shall not be unreasonably delayed or withheld, and shall assure that the
purity of Kinetin so purchased shall be no less than 99% with proof of biological activity and other efficacy of the Licensee Products to be established by Licensee or its supplier, and Licensee will use Best Efforts to obtain from its supplier the
right for Senetek to source its own requirements of Kinetin directly from such supplier at the same pricing and other terms as are provided to Licensee. Senetek shall have the right to conduct reasonable audits of Licensee’s contract
manufacturing sites and its and its contract manufacturer’s and Kinetin vendor’s records and quality assurance/quality control procedures for raw materials, componentry, packaging and finished product. At such time as Licensee assumes
manufacturing for each Licensee Product, Licensee shall purchase from Senetek and its contract manufacturers all dedicated raw materials, tools, dies, moulds, componentry, and other materials related to the Licensee Product whose manufacturing is
being transferred, at Senetek’s or its manufacturer’s fully absorbed cost. 
  
 3.10 Packaging and Labeling. Licensee hereby grants to Senetek a license to utilize the Licensee trademarks set forth in Schedule
3.10 to the extent required to package and label the Senetek Products, said license to expire upon expiration of this Agreement. Licensee represents and warrants that to the best of its knowledge such trademarks are not identical or confusingly
similar to any registered or common law trademark of any third party for Class 3 or Class 5 products in the Territory, and Licensee agrees during the Term not to use such 

  

 9 

 
trademarks in connection with the marketing or sale of any product that is not a Product, and after the Term not to use such trademarks in any way that is
confusingly similar to its use on Products during the Term (subject to Licensee’s right to sell off Product lawfully in its possession pursuant to Section 2.4). Licensee shall give Senetek written Notice setting forth the labeling it proposes
for each Product. If Senetek does not give Notice to Licensee within ten (10) days after receipt of Licensee’s Notice, setting forth its objections to any such labeling (which may only be based upon FDA, FTC or other legal or regulatory
non-compliance), Senetek shall be deemed to have no objection to such labeling. Senetek hereby grants to Licensee a license to utilize the Senetek trademarks set forth in Schedule 3.10 to the extent required to package and label the Licensee
Products, said license to expire upon the expiration of this Agreement, and Senetek represents and warrants that to the best of its knowledge such trademarks are not identical or confusingly similar to any registered or common law trademarks of any
third party for Class 3 or Class 5 products in the Territory. All primary packaging, unit cartons and inner shippers for Products shall conspicuously state that such Products are covered by “Patent Numbers 5,371,089, 5,602,139 and others”.

  
 3.11 Royalty Due on Net Sales of
Products. A royalty shall be due to Senetek with respect to all Net Sales of Products by Licensee or its Affiliates or sub-licensees as follows: 
  
 (i) On each Unit of Senetek Products manufactured by Senetek or its authorized suppliers and purchased by Licensee at the Base Price then
in effect (and on each Unit of Licensee Products manufactured by or for Senetek prior to Licensee’s assumption of manufacturing or during a Disruption Period and purchased by Licensee at the Base Price then in effect), * percent (*%) of Net
Sales, and 
  
 (ii) On each Unit of Licensee
Products manufactured by Licensee or its authorized suppliers (and on each Unit of Senetek Product manufactured by or for Licensee during a Disruption Period), * percent (*%) of Net Sales. 
  
 All royalties due shall be paid with respect to each
Calendar Quarter within thirty (30) days after the end of such Calendar Quarter. Payments shall be made by wire transfer to the bank account designated by Senetek from time to time in U.S. Dollars, and any late payments shall be subject to a
handling charge of the lesser of one percent (1%) per month or the maximum interest rate allowed by applicable law from the date payment was due. All royalty payments shall be followed within ten (10) days by a reasonably detailed accounting setting
forth the basis upon which such payment was calculated 
  
 3.12 Minimum Payments. Subject to Section 3.14, to maintain the Exclusivity Right in the Core Territory, during the first Contract Year Licensee’s Net Payments of royalties due to Senetek pursuant to Section 3.11 and Base Price
pursuant to Section 3.1 shall not be less than three million dollars ($3,000,000) (the “Minimum Payments”). Within sixty (60) days after the end of the first and each subsequent Contract Year, Senetek and Licensee shall negotiate in good
faith with respect to the Minimum Payments to be required for such Contract Year, provided that if the parties fail to reach agreement with respect thereto by the end of the first Calendar Quarter, then the Minimum Payments applicable to such
Contract Year shall be equal to the Minimum Payments applicable to the preceding Contract Year. 

	*	Confidential treatment has been requested for these terms. 

  

 10 

 3.13 Adjustment to First Contract Year Minimum Payments. The parties acknowledge
that the initial Minimum Payments figure above provided for the first Contract Year does not reflect their complete assessment of the commercial potential of the Exclusivity Right granted with respect to that portion of the Core Territory comprised
of the European Union and Australia. Not later than thirty (30) days after the Agreement Date, Senetek and Licensee shall use Best Efforts to reach agreement with respect thereto. If by such date the parties have reached agreement, the Minimum
Payments provided for in Section 3.12 shall be increased to such amount as the parties may agree. If by such date the parties have failed to reach agreement, then the definition of Core Territory shall be deemed amended so as to exclude the European
Union and Australia, the definition of Non-Exclusive Territory shall be deemed amended to include the European Union and Australia, and the Minimum Payments provided for in Section 3.12 shall be reduced to *. 
  
 3.14 Prepayment Equal to First Contract Year’s
Initial Minimum Payments. On the Agreement Date, Licensee shall make a non-refundable lump sum payment to Senetek of three million dollars ($3,000,000) as a prepayment against the first three million dollars ($3,000,000) of royalties due
pursuant to Section 3.11 and Base Price due pursuant to Section 3.1 No amount of the prepayment above provided for shall be repayable to Licensee if the initial first Contract Year’s Minimum Payments figure is reduced as provided for in Section
3.13. Any amount by which such lump sum payment exceeds royalties due and Base Price payable during the first Contract Year shall be carried over and applied to subsequent Contract Years until such time as the prepaid amount has been exhausted.

  
 4. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PARTIES 

 
 4.1 Representations, Warranties and Covenants of
Licensee.  
  
 Licensee represents, warrants
and covenants as follows: 
  
 4.1.1
Qualifications and Authorization. Licensee is a corporation duly formed, validly existing and in good standing under the laws of Delaware with full corporate power and authority to conduct its business as it is now conducted and to enter into
and perform this Agreement. Licensee is duly licensed or qualified to do business and is in good standing in each jurisdiction in which its operations or ownership of assets or its performance of this Agreement requires such licensing or
qualification. 
  
 4.1.2 No Conflict or
Violation. Neither the execution, delivery or performance of this Agreement, nor compliance by Licensee with any of the provisions hereof, will (i) violate or conflict with any provision of the Certificate or Articles of Incorporation or Bylaws
of Licensee, (ii) violate, conflict with, or result in a breach of any provision of, or constitute a default (or an event which, with notice or lapse of time or both, would constitute a default) under, or result in the creation of any encumbrance
upon any of Licensee’s assets under, any of the terms, conditions or provisions of any material contract, indebtedness, note, bond, indenture, security or pledge agreement, commitment, license, lease, franchise, permit, agreement, or other
instrument or obligation to which Licensee is a party, or (iii) violate any statute, rule, regulation, ordinance, code, order, judgment, ruling, writ, injunction, decree or award applicable to Licensee, except, in the case of each of 

	*	Confidential treatment has been requested of these terms. 

  

 11 

 
clauses (i), (ii) and (iii) above, for such violations, conflicts, breaches, defaults or creations of encumbrances which, in the aggregate, would not have a
material adverse affect on the business of Licensee taken as a whole or any adverse effect on its ability to fully perform this Agreement. 
  
 4.1.3 Compliance with Laws. Licensee shall comply in all material respects with all laws, regulations, ordinances, orders, decrees
and other requirements applicable to the storage, shipment, marketing and sale of the Products and the manufacture of the Licensee Products. Without limiting the foregoing, Licensee shall conduct appropriate stability testing of the Licensee
Products, shall maintain and implement appropriate quality control and quality assurance procedures for all Products held in inventory, and shall obtain and maintain all Product marketing approvals, registrations or other permits necessary for the
lawful packaging, storage, shipment, marketing and sale of the Products in the Authorized Channel in each country within the Territory in which Products are sold. 
  
 4.1.4 Marketing Efforts; Promotion Commitment. Licensee will promote and market the Products in a
manner consistent with general industry practice and in full compliance with all laws, rules and regulations applicable thereto in each place where the same are promoted and marketed. During at least the first Contract Year, the Products will be
promoted and marketed as Licensee’s second most important product line. Licensee shall give Notice to Senetek of its proposed advertising copy for the Products prior to use. If Senetek does not give Notice to Licensee objecting to any such
advertising copy within ten (10) days after receipt of Licensee’s Notice (which objection shall be limited to FDA, FTC or other legal or regulatory non-compliance), Senetek shall be deemed to have no objection. 
  
 4.1.5 Packaging License. Licensee and its Affiliates
own or hold subsisting licenses or other rights to the intellectual property licensed to Senetek pursuant to Section 3.11, and have the full and unrestricted right to license it to Senetek for purposes of Senetek producing Senetek Product packaging
and labeling. Licensee has no knowledge of the existence of any intellectual property owned by any other Person that would prevent Senetek from making or having made the packaging and labeling for the Senetek Product or prevent Licensee from selling
Products using such intellectual property on packaging and labeling in the Authorized Channel within the Territory. 
  
 4.1.6 Covenant Not to Challenge Senetek Patents’ Validity or, Enforceability. In consideration of the benefits of this
Agreement, Licensee, for itself and its Affiliates, successors and permitted assigns and sub-licensees, covenants that it and they will not dispute the validity and enforceability of the Patents in any proceeding of any nature, will not assert,
either affirmatively or defensively, in any proceeding of any nature, any matter inconsistent with said validity and enforceability, agrees and acknowledges that the foregoing shall act as a complete defense and bar to any proceeding of any nature
challenging such validity and enforceability or any of them, and consents to the entry of temporary and permanent injunctions to bar any breach or threatened breach of any of the foregoing, without the filing on behalf of Senetek of any bond or
other security. This Section 4.1.6 will terminate and be of no force or effect in the event that Senetek terminates this Agreement for any reason or is in material breach of this Agreement. 
  

 12 

 4.1.7 No Unsolicited Bids. Licensee, for itself and its Affiliates, successors and
permitted assigns and sub-licensees, irrevocably agrees that from the Agreement Date through the fifth anniversary of the end of the Term it and they will not, individually or as a member of any “group” (as such term is defined under the
United States Securities Exchange Act) (i) purchase, own or acquire rights in securities of Senetek or American Depositary shares representing, or options, warrants or other rights to purchase, securities of Senetek, representing in the aggregate
five percent (5%) or more of the outstanding equity securities of Senetek, or (ii) make any public or confidential offer or proposal to Senetek or its management or Board of Directors or any member thereof with a view to entering into any
acquisition of or combination involving Senetek or any of its material assets, or (iii) participate in any proxy contest or other process intended to cause the adoption of any shareholder resolution which has not been recommended for adoption by the
Board of Directors of Senetek. This Section 4.1.7 will terminate and be of no force or effect in the event that (a) any party other than Licensee or any Affiliate of Licensee or “group” of which Licensee or any Affiliate is a member takes
any of the actions described in clauses (i), (ii) or (iii) or (b) Senetek terminates this Agreement for any reason or is in material breach of this Agreement. 
  

4.2 Representations and Warranties and Covenants of Senetek. 
  
 Senetek represents, warrants and covenants as follows: 
  
 4.2.1 Qualifications and Authorization. Senetek is a
corporation duly organized, validly existing and in good standing under the laws of England, with full corporate power and authority to conduct its business as it is now conducted and to enter into and perform this Agreement. Senetek is duly
licensed or qualified to do business and is in good standing in California and each other jurisdiction in which its operations or ownership of assets in connection with this Agreement requires such licensing or qualification. 
  
 4.2.2 No Conflict or Violation. Neither the
execution, delivery or performance of this Agreement, nor compliance by Senetek with any of the provisions hereof, will (i) violate or conflict with any provision of the Memorandum or Articles of Association of Senetek, (ii) violate, conflict with,
or result in a breach of any provision of, or constitute a default (or an event which, with notice or lapse of time or both, would constitute a default) under, or result in a creation of any encumbrance upon any of Senetek’s assets under, any
of the terms, conditions or provisions of any material contract, indebtedness, note, bond, indenture, security or pledge agreement, commitment, license, lease, franchise, permit, agreement, or other instrument or obligation to which Senetek is a
party, or (iii) violate any statute, rule, regulation, ordinance, code, order, judgment, ruling, writ, injunction, decree or award applicable to Senetek, except, in the case of each of clauses (i), (ii) and (iii) above, for such violations,
conflicts, breaches, defaults or creations of encumbrances which, in the aggregate, would not have material adverse effect on the business of Senetek and its Affiliates taken as a whole or any adverse effect on its ability to perform this Agreement.

  

 13 

 4.2.3 Product Manufacture. The Senetek Products will be, and such of the Licensee
Products as Senetek manufactures will be, manufactured in accordance with the Specifications as from time to time in effect and in compliance with the existing master batch record, current good manufacturing practices for cosmetic products, and all
laws, regulations, ordinances, order, decrees and other requirements applicable to the manufacture, packaging, storage and shipment of the Senetek Products in accordance with this Agreement. The Kinetin used in the manufacture of such Products shall
be no less than 99% pure. Senetek shall assay the biological activity and other efficacy of such Products using such means and at such frequency as Senetek may reasonably determine. 
  
 4.2.4 Patents. Senetek and its Affiliates own the Patents and either own or hold licenses for the use
of the other Intellectual Property and Documentation, and have the full and unrestricted right to license them to Licensee. Senetek has no knowledge of the existence of any patent or patent applications or trademark or copyright owned or filed by
any Person that would prevent Senetek from making or having made the Senetek Products or prevent Licensee from manufacturing, packaging, marketing or selling Products in the Authorized Channel within the Territory. As of the Agreement Date, Senetek
has not entered into any subsisting material license agreement with respect to its Patents except as disclosed on Schedule 4.2.4. Except as disclosed on Schedule 4.2.4, Senetek is not as of the date of this Agreement involved in any material dispute
with respect to the agreements identified on such schedule. During the Term of this Agreement Senetek and its Affiliates will not enter into any license or other agreement with respect to the Patents or other Intellectual Property which conflicts
with this Agreement or the rights granted Licensee hereunder. To the best of Senetek’s knowledge, the Intellectual Property and the Know-How (in conjunction with the Licensee intellectual property applicable thereto) include all patents, common
law and statutory trademarks, trade names, copyrights, designs, trade secrets and technical or other proprietary information necessary for the manufacture, distribution, promotion, marketing and sale of the Products listed in Schedules 1.4 and 1.19
hereof in accordance with the terms of this Agreement. 
  
 4.2.5 Product Claim Substantiation; Testing Data. Senetek has made available to Licensee all currently existing, and will continue to make available to Licensee all future, Product claim substantiation and safety testing data related
to the Products, including all University of California—Irvine test data and copies of “results” photographs taken by Canfield Scientific, as may be reasonably necessary to permit Licensee to advertise and promote the Products in
accordance with this Agreement; provided, however, that Senetek shall not be required to disclose such information to the extent that doing so would violate agreements with others and it has used Best Efforts to obtain a waiver or amendment
of such provisions to permit such disclosure. 
  
 4.3 Survival. The representations and warranties made in this Agreement shall survive the termination of this Agreement for the full period prescribed by the statute of limitations applicable to claims for the breach of such
representation or warranty. The covenants of the parties made in this Agreement shall continue in full force and effect after the termination of this Agreement without limit. 
  

 14 

 5. CONFIDENTIAL INFORMATION AND ANNOUNCEMENTS 
  
 5.1 Senetek Confidential Information. Licensee shall not (a) use Senetek Confidential Information
except to perform its obligations under this Agreement, or (b) disclose Senetek Confidential Information to any Person (except to its employees and agents who reasonably require same for the purpose hereof and who are bound to Licensee by the same
obligations as to confidentiality) without the express written permission of Senetek, unless such disclosure is required by order of a court of competent jurisdiction. 
  
 5.2 Licensee Confidential Information. Senetek shall not (a) use Licensee’s Confidential
Information except to perform its obligations under this Agreement, or (b) disclose Licensee’s Confidential Information to any Person (except to its employees and agents who reasonably require same for the purpose hereof and who are bound to
Senetek by the same obligations as to confidentiality) without the express written permission of Licensee, unless such disclosure is required by order of a court of competent jurisdiction. 
  
 5.3 No License. The furnishing of Confidential
Information by one party to the other shall not constitute any grant, option or license to the other under any Patent or Intellectual Property of Senetek or any intellectual property of Licensee. 
  
 5.4 Announcements. Senetek will issue an agreed upon
press release upon the execution of this Agreement in the form set forth in Schedule 5.4. Except for such release and except as may otherwise be required by law or the listing rules of any exchange on which either party’s securities may be
listed or quoted, for which the releasing party shall provide prior notice to the other party and the opportunity to comment on any required disclosure, neither party will disclose the terms of this Agreement to any other Person; provided, however,
that each party may make such disclosure of the terms of this Agreement to its employees and agents as is necessary to permit such party to perform its obligations under this Agreement; provided further that any such employee or agent agrees to
maintain the confidentiality of this Agreement; and provided further that either party may make such disclosures of the terms of this Agreement as are necessary to enter into license and other agreements that do not conflict with the terms of this
Agreement. Licensee acknowledges that this Agreement may be deemed to be a “material contract” as that term is defined by Item 601(b)(10) of Regulation S-K, and that Senetek may therefore be required to file such document as an exhibit to
reports or registration statements filed under the United States Securities Act or Securities Exchange Act, provided that Senetek shall redact commercial terms and file for confidential treatment to the extent permitted by applicable rules of the
United States Securities and Exchange Commission. 
  
 5.5 Release from Restrictions. The restrictions set forth in Sections 5.1 and 5.2 shall not apply to Licensee or Senetek Confidential Information disclosed to the other party (i) that a party rightfully possessed before it received
the information from the other as evidenced by written documentation; (ii) that subsequently becomes publicly available through no fault of that party; (iii) that is subsequently furnished rightfully to that party by a third party that is not an
Affiliate and which is not known to be under restrictions on such disclosure; or (iv) that is independently developed by an employee, agent or contractor of such party. 
  

 15 

 5.6 Survival. The provisions of this Article 5 shall survive termination of this
Agreement and continue thereafter for a period of five (5) years. 
  
 6. BOOKS
AND RECORDS; DISPUTE RESOLUTION 
  
 6.1
Books and Records. Each party shall keep (and shall cause any permitted contract manufacturer to keep) books and records sufficient to permit the other party to verify compliance with all of the representations, warranties and covenants
contained herein, including with respect to the Base Price of Products from time to time manufactured by it. In the case of Licensee, such books and records shall accurately reflect all amounts included in its calculation of royalty due with respect
to Products and shall be prepared in accordance with GAAP, and Licensee shall maintain source documentation of the amounts therein reflected. Such books and records shall be preserved for a period not less than three (3) years after they are created
during and after the Term of this Agreement. Each party shall be permitted to audit all appropriate books and records (including those of any contract manufacturer). Such audit shall only be performed by a third party licensed certified public
accountant who has agreed to be bound by obligations of confidentiality and non-use, upon reasonable notice and during regular business hours. A party shall conduct no more than one (1) such audit during any Contract Year unless any prior audit
showed material breach of a representation, warranty or covenant, in which event the a party may conduct no more than two (2) audits during the succeeding Contract Year. Each party shall pay its own costs of conducting any such audit unless it is
determined by Final Adjudication that the party whose books and records were audited was in material breach (which with respect to this provision shall be defined as an underpayment in excess of ten percent (10%)), in which event it shall pay all
reasonable costs of such audit. The party conducting any audit hereunder shall give Notice of the results of such audit to the other party as soon as reasonably practicable following its conclusion. Settlement for all underpayments and overpayments
shall be made within thirty (30) days following such Notice. 
  
 7.
INDEMNIFICATION, INSURANCE AND LIMITS ON LIABILITY 
  
 7.1 Indemnification by Licensee. Licensee shall defend, indemnify, and hold harmless Senetek, its officers, agents, employees and Affiliates from any loss and from any claim, action, damage, expense or liability (including defense
costs and attorneys’ fees) (collectively, “Claims”) arising out of or related to a breach or alleged breach of any representation, warranty or covenant made by Licensee herein, or the marketing, sale or use of Products or the
manufacture of Licensee Products, except insofar as such claims are related to or arise from Senetek’s negligence, willful misconduct or breach of any representation, warranty or covenant made by Senetek under this Agreement. 
  
 7.2 Indemnification by Senetek. Senetek shall defend,
indemnify, and hold harmless Licensee, its officers, agents, employees and Affiliates from any Claims arising out of or related to a breach or alleged breach of any representation, warranty, or covenant made by Senetek herein, or the manufacture of
Senetek Products, except insofar as such claims are related to or arise from Licensee’s negligence, willful misconduct or breach of any representation, warranty or covenant made by Licensee under this Agreement. 
  

 16 

 7.3 Insurance. Each party shall maintain at its expense commercial general
liability insurance with an insurance company or companies rated at least Best AA in a principal amount of not less than Two Million Dollars (US$2,000,000) per occurrence and Five Million Dollars (US$5,000,000) in the annual aggregate. Each such
policy shall name the other party as an additional insured as its interest may appear. Within thirty (30) calendar days after the date of this Agreement, each party shall furnish to the other a certificate evidencing such insurance. Either party may
elect to suspend its performance hereunder until the other party’s insurance is in place and the certificate of coverage is provided, and may thereafter suspend its performance if it reasonably believes such insurance is not in place until the
other party provides reasonable assurance that such coverage is in place without any gap in coverage during the Term and will be maintained as required by this Agreement. 
  
 7.4 No Consequential Damages. Except for claims that include consequential damages paid to Persons
that are not an indemnified party or Affiliates or sub-licensees of an indemnified party, neither party shall be liable to the other for consequential damages, lost profits, injury to reputation or similar claims; provided, however, that
nothing in this sentence shall be construed to in any way limit Licensee’s obligation to order and pay for Senetek Products or pay royalty due on Net Sales of Products under this Agreement. UNDER NO CIRCUMSTANCES SHALL SENETEK OR ITS AFFILIATES
HAVE ANY LIABILITY ARISING FROM THIS AGREEMENT IN EXCESS OF THE HIGHEST AGGREGATE AMOUNT PAID AS BASE PRICE AND ROYALTIES FOR PRODUCTS IN ANY ONE OF THE THREE PRECEDING CONTRACT YEARS. Each party acknowledges and agrees that, but for the limitations
of liability set forth in this Section, the other party would not have entered into this Agreement upon the terms set forth herein and that such limitations are a material part of this Agreement. 
  
 7.5 Recalls. In the event any Product(s) must be
recalled from distribution by reason of failure to meet any requirements of law or otherwise, Licensee shall have the sole responsibility to effect the recall. Senetek shall use Best Efforts to cooperate with Licensee in implementing any such recall
to the extent such cooperation is necessary to effect the recall, provided Licensee shall pay Senetek’s out-of-pocket expenses related thereto, subject to any subsequent claim under Section 7.2. In the event the recall results from or is
caused by the negligence, willful misconduct or breach of any representation, warranty or covenant made by Senetek herein, Senetek shall reimburse Licensee for any costs and/or expenses reasonably expended by Licensee as a consequence of the recall.

  
 8. INFRINGEMENT 
  
 8.1 Notification of Infringement. During the
Term, each party shall promptly advise the other in writing of any infringement, imitation or act by third parties inconsistent with the ownership of and rights to the Intellectual Property as represented in this Agreement or any act of unfair
competition by third parties (any of the foregoing shall be referred to as an “infringement”) relating to any of the Intellectual Property, wherever and whenever such infringement or act shall come to the attention of such party. Senetek
shall promptly take such 

  

 17 

 
commercially reasonable action as is required to restrain such infringement or otherwise enforce its rights, and Licensee shall cooperate fully in such
action and, if so requested, shall join as a party to any appropriate legal proceedings for such purpose. If within 30 days after Senetek becomes aware of such infringement, Senetek fails to commence appropriate and diligent action with respect to
such infringement, Licensee shall have the right, to the extent permitted by law, to institute an action for infringement in its own name or in the name of any of its Affiliates. To the extent Licensee exercises such right to take action, all
reasonable expenses thereof shall be recouped from any recovery and any unrecouped reasonable expenses shall be credited towards royalties and Base Price otherwise due under this Agreement. 
  
 8.2 Recovery. Any recovery by either party as a
result of any claim, demand, litigation or other action contemplated by Section 8.1 or any settlement thereof shall first be used to reimburse each party for the reasonable costs of the action borne by such party (or, if the recovery is less than
the aggregate costs of such action, shall be distributed between the parties in proportion to the costs of the action borne by each of the parties), with the remaining amount, if any, to be paid to the party bringing the action. 
  
 9. TERM AND TERMINATION 
  
 9.1 Term. The term of this Agreement shall be the Term as defined in Article 1 unless terminated
earlier than therein provided pursuant to this Article 9. 
  
 9.2 Termination for Cause. Each party shall have the right to terminate this Agreement at any time upon written notice to the other in the event (i) the other party is found by Final Adjudication by a court of
competent jurisdiction to be in material breach of any of the provisions of this Agreement and such material breach continues for a period of sixty (60) days after Notice thereof or (ii) the other party is declared insolvent or bankrupt by a court
of competent jurisdiction, or a voluntary petition of bankruptcy is filed in any court of competent jurisdiction by the other party, or the other party makes or executes any assignment for the benefit of creditors. Notwithstanding the foregoing, in
the case of a failure by Licensee to make the Minimum Payments, Licensee shall have the right to cure such failure and preserve the Exclusivity Right by payment to Senetek of an amount equal to the amount by which Licensee failed to pay the Minimum
Payments. For the avoidance of doubt, the Minimum Payments provisions of this Agreement are not a minimum purchase commitment, minimum Net Sales commitment, or obligation to make minimum royalty payments, but merely a threshold that must be met to
maintain the Exclusivity Right under this Agreement. Failure to make such Minimum Payments shall not be a breach or otherwise a cause for termination of this Agreement. 
  
 9.3 Bankruptcy of Senetek. The parties hereby agree that licenses under this Agreement are licenses
of intellectual property as defined in Section 101(35A) (formerly Section 101(56)) of the Bankruptcy Code, and that this license agreement is governed by Section 365(n) of the Bankruptcy Code. Senetek hereby agrees that in the event this Agreement
is assigned to any third party in any bankruptcy action by Senetek, such assignee must assume all of Senetek’s obligations under this Agreement. 
  

 18 

 9.4 Termination Without Cause by Licensee. Licensee may terminate this Agreement
without cause at any time after the end of the first Contract Year upon twelve (12) months written Notice to Senetek. 
  
 10. MISCELLANEOUS 
  
 10.1 Method of Payments. All payments due under this Agreement shall be paid in U.S. Dollars by wire transfer of immediately
available funds to Senetek in the United States. Net Sales in non-U.S. Dollar currencies shall be converted to U.S. Dollars in accordance with GAAP consistently applied by Licensee in preparing its audited consolidated financial statements.

  
 10.2 Taxes. All taxes due with respect
to the sales of Products by Licensee shall be paid by it. If Senetek is required to collect and remit any tax for which Licensee is responsible, Senetek shall be entitled to collect the amount of such tax from Licensee within 30 days of the date any
such tax is due. 
  
 10.3 No Joint
Venture. It is not the intent of the parties hereto to form any partnership or joint venture. Each party shall, in relation to its obligations hereunder, act as an independent contractor, and nothing in this Agreement shall be construed to give
either party the power or authority to act for, bind or commit the other. 
  
 10.4 Governing Law. This Agreement shall be governed by and interpreted in accordance with the laws of the State of California (regardless of that or any other jurisdiction’s choice of law principles).
Each party irrevocably submits to the exclusive jurisdiction of the United States Federal District Court for the Northern District of California and the state courts of California sitting in San Francisco for all purposes related to this Agreement.

  
 10.5 No Assignment. Neither party to
this Agreement may assign its rights or obligations under this Agreement without the prior written consent of the other party to this Agreement; provided, however, that either party may assign its rights to an Affiliate or to any successor by
merger, consolidation, sale of stock or the sale of substantially all of the assets of such party; provided further, that no such permitted assignment shall relieve the assigning party of its liability for any breach by its assignee. Licensee
may not sub-license any of its rights hereunder without the prior written consent of Senetek, which shall not be unreasonably withheld or delayed. Any permitted sublicense shall require that the sub-licensee agree in writing to comply with the terms
of this Agreement and shall name Senetek as a third-party beneficiary with rights of enforcement. No sub-licensee shall have any right to grant additional sublicenses, and any attempt to grant such a further sublicense shall automatically terminate
the sub-license under which such additional sub-license purportedly was granted. 
  
 10.6 Force Majeure. No party hereto shall be liable to any other in damages for, nor shall this Agreement be terminable by reason
of, any delay or default in such party’s performance hereunder if such delay or default is caused by conditions beyond such party’s control including, but not limited to, acts of God, regulation or law or other action of any 

  

 19 

 
government or any agency thereof, war, insurrection, civil commotion, destruction of production facilities or materials by earthquake, fire, flood or storm,
labor disturbances, epidemic, or failure of suppliers, public utilities or common carriers. Each party hereto agrees to promptly notify the other party of any event of force majeure under this Section 10.6 and to employ Best Efforts towards prompt
resumption of its performance hereunder if such performance is delayed or interrupted by reason of such event. In the absence of a force majeure event involving material impairment or destruction of manufacturing capability or supply chain for
Product, no force majeure event shall be deemed to excuse the failure of Licensee to pay the Minimum Payments applicable to any Contract Year. 
  
 10.7 Notices. Unless otherwise provided herein, any notice required or permitted to be given hereunder (a “Notice”) shall
be mailed by certified mail or generally recognized express courier service with signature required for delivery, postage prepaid, sent by facsimile transmission, or delivered by hand to the party to whom such Notice is required or permitted to be
given hereunder, at such party’s address first set forth above or at such other address as the party may have designated by Notice hereunder. If mailed, any such Notice shall be deemed to have been given as of the date of receipt, as evidenced
by the date appearing on the delivery notice. If delivered by hand, any such Notice shall be deemed to have been given when received by the party or agent of such party to whom such Notice is given, as evidenced by written and dated receipt of the
receiving party. 
  
 10.8 Captions. The
captions in this Agreement are solely for convenience of reference and shall not be used for purposes of interpreting or construing the provisions hereof. 
  
 10.9 Severability. Should any part or provision of this Agreement be held unenforceable or in conflict with the applicable laws or
regulations of any jurisdiction, the invalid or unenforceable part or provision shall be replaced with a provision which accomplishes, to the extent possible, the original business purpose of such part or provision in a valid and enforceable manner,
and the remainder of this Agreement shall remain binding upon the parties hereto. 
  
 10.10 Waiver. No failure on the part of any party hereto to exercise, and no delay in exercising, any right, privilege or
power hereunder shall operate as a waiver or relinquishment thereof; nor shall any single or partial exercise by any party hereto of any right, privilege or power hereunder preclude any other or further exercise thereof, or the exercise of any other
right, privilege or power. 
  
 10.11 Entire
Agreement. This Agreement together with its Schedules constitutes the entire agreement and understanding between the parties hereto with respect to the subject matter of this Agreement and shall supersede any prior agreements, negotiations,
understandings, representations, statements and writings relating thereto. This Agreement may not be amended or modified except in a writing signed by a duly authorized officer of the party against whom enforcement of such amendment is sought.

  

 20 

 10.12 Counterparts. This Agreement may be executed in one or more counterparts by
exchange of facsimile copies of signature pages, each of which will be deemed an original and all of which together will constitute one and the same instrument. 
  
 10.13 Document Preparation. The Parties acknowledge that this Agreement is a product of extensive
negotiations and that no inference should be drawn regarding the preparation of this document. 
  
 To evidence this Agreement, the parties have caused their duly authorized representatives to execute this Agreement as of the Agreement Date. 

 

	ICN PHARMACEUTICALS, INC.
	
	 By:  /s/    WESLEY P.
WHEELER      

	
	 Name: Wesley P. Wheeler

	 Title: President

	
	SENETEK PLC
	
	 By:  /s/    FRANK J.
MASSINO

	
	 Name: Frank J. Massino

	 Title: Chairman and Chief Executive Officer

	
	CARME COSMECEUTICAL SCIENCE, INC.
	
	 By:  /s/    FRANK J.
MASSINO

	
	 Name: Frank J. Massino

	 Title: President

  

 21 

 SCHEDULE 1.4 
 SENETEK PRODUCT 
  

	 Product Description

	  	Unit Base Price

	 Vitamin C Serum w/ 0.025 Kinetin – 15 ml
	  	$	*

  
 *
Confidential treatment has been requested of these terms. 
  

 22 

 SCHEDULE 1.10 
 DOCUMENTATION 
  

	1.	Kinetin pre-Clinical Safety Studies 

  

	 	A.	STK 1—Ames Test 

	 	B.	STK 2—Mouse Lymphoma TK Locus Assay 

	 	C.	STK 4—Acute Oral Toxicity to Mice 

	 	D.	STK 6—Acute Oral Toxicity to Rats 

	 	E.	STK 7—Acute Dermal Toxicity to Rats 

	 	F.	STK 8—Irritant Effects on Rabbit Skin 

	 	G.	STK 9 –Irritant Effects on the Rabbit Eye 

	 	H.	STK 10—Delayed Contact Hypersensitivity in Guinea Pig 

	 	I.	STK 15—Kinetin and Furfural Bacterial Mutation Assay 

	 	J.	STK 30—Mouse Micronucleus Test 

  

	2.	Kinetin Clinical Safety Studies 

  

	 	A.	KTN 001 

	 	B.	KTN 003 

  

	3.	Kinetin In-vitro Skin Penetration Studies 

  

	4.	Kinetin Raw Material Test HPLC Procedure and Specifications (current supplier) 

  

	5.	Product Composition and Manufacturing Instructions for Formulae Developed by Senetek. 

  

	6.	Product Specifications for Formulae Developed by Senetek PLC. 

  

	7.	Kinetin HPLC Assay Procedure for Formulated Products 

  

 23 

 SCHEDULE 1.17 
 PATENTS 
  

	 Title

	  	Country

	  	Status

	  	Application
No.

	  	Patent No.

	  	Patent
Date

						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Argentina	  	Granted	  	320120	  	250273	  	1/28/97
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Australia	  	Granted	  	81884/91	  	666836	  	7/9/96
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Austria	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Belgium	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Brazil	  	Granted	  	2108368	  	P19107307	  	10/31/00
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Canada	  	Granted	  	 	  	1,339,503	  	10/21/97
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Canada	  	Pending	  	2108369	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	China	  	Granted	  	91104472.8	  	ZL91104472	  	6/3/96
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	European
Patent
Office	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Finland	  	Pending	  	935039	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	France	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Germany	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Great
Britain	  	Granted	  	91912579.9	  	0584068	  	10/6/99

  

 24 

	 Title

	  	Country

	 	Status

	  	Application
No.

	  	Patent No.

	  	Patent
Date

						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Greece	 	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Ireland,
Republic
of	 	Pending	  	1715/91	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Israel	 	Granted	  	98204	  	98204	  	2/12/95
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Japan	 	Granted	  	512066/91	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	 Japan
 (divisional)
	 	Pending	  	3103375	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Luxem-
bourg	 	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Korea,
South	 	Granted	  	703452/93	  	196660	  	2/22/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Malaysia	 	Pending	  	PI9100865	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Mexico	 	Granted	  	25,886	  	178834	  	7/2/95
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Nether-
lands	 	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	New
Zealand	 	Granted	  	238210	  	238210	  	10/1/93
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	New
Zealand	 	Granted	  	247836	  	247836	  	8/8/97
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Norway	 	Granted	  	934115	  	304814	  	2/22/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Philippines	 	Pending	  	42893	  	 	  	 

  

 25 

	 Title

	  	Country

	  	Status

	  	Application
No.

	  	Patent No.

	  	Patent
Date

						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Saudi
Arabia	  	Pending	  	91120262	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Spain	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Sweden	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Switzer-
land	  	Granted	  	91912579.9	  	0584068	  	10/6/99
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Taiwan	  	Granted	  	80105893	  	76376	  	5/23/96
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	Venezuela	  	Pending	  	727	  	 	  	 
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	U.S.	  	Granted	  	206,041	  	5,371,089	  	12/6/94
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	U.S.	  	Granted	  	292,721	  	5,602,139	  	2/11/97
						
	Method and Composition for Ameliorating the Adverse Effects of Aging	  	U.S.	  	Granted	  	314,361	  	5,614,507	  	3/25/97

  

 26 

 SCHEDULE 1.19 
 LICENSEE PRODUCTS 
  

	 Description (Specification_attached)

	  	Unit Base
Price

	 1.      Kinerase Cream w/ 0.1% Kinetin – 40g
	  	$	*
	 2.      Kinerase Cream w/ 0.1% Kinetin – 80g
	  	$	*
	 3.      Kinerase Lotion w/ 0.1% Kinetin – 40g
	  	$	*
	 4.      Kinerase Lotion w/ 0.1% Kinetin – 80g
	  	$	*
	 5.      Kinerase SPF + 0.1% Kinetin – 40g
	  	$	*
	 6.      Kinerase SPF + 0.1% Kinetin – 80g
	  	$	*
	 7.      Kinerase Cream w/ 0.125% Kinetin – 20g
	  	$	*
	 8.      Kinerase Cream w/ 0.125% Kinetin – 80g
	  	$	*
	 9.      Kinerase Lotion w/ 0.125% Kinetin – 40g
	  	$	*
	 10.    Kinerase Lotion w/ 0.125% Kinetin – 80g
	  	$	*
	 11.    Kinerase Vitamin C Cream + 0.1% Kinetin – 40g
	  	 	See below

  
 Licensee will assume manufacturing
responsibility for this product as of the Agreement Date, purchasing finished product in bulk from Grant Industries and paying to Shaklee Corporation its royalty due of *         per Unit purchased from Grant.

  

	*	Confidential treatment has been requested of these terms. 

  

 27 

 SCHEDULE 4.2.4 
 OTHER LICENSE AGREEMENTS 
  

	1.	Revlon Consumer Products Corporation 

  

	2.	Osmotics Corporation 

  

	3.	The Body Shop 

  

	4.	Allure Cosmetics 

  

	5.	Med-Beauty AG 

  

	7.	Vivier Pharma Inc. 

  

	8.	Shaklee Corporation 

  

	9.	Panion & BF Biotech Inc. 

  

	10.	Enprani Co., Ltd. 

  

	11.	Lavipharm SA 

  

 28 

 SCHEDULE 6.4 
 PRESS RELEASE 
  
 Senetek
Announces Expanded Kinetin License With 
  
 ICN
Pharmaceuticals, Inc. 
  
 Napa, California, July ,
2003/PRNewswire-FirstCall/ —Senetek PLC (Nasdaq: SNTK – News), www.senetekplc.com, Napa, California, today announced the signing of an expanded manufacturing license with ICN Pharmaceuticals, Inc. for products
containing Senetek’s patented skin care ingredient, Kinetin. Under the expanded agreement, ICN will add five new Kinetin products to its existing Kinerase® product line, including new intense serum and cream formulations with highly stabilized Vitamin C, a Kinerase sun
screen formulation and new higher concentration cream and lotion formulations. The expanded line will be sold through the ethical market channel world-wide, supported by an enhanced sales efforts to physicians, dermatology clinics and other
recognized medical channels supported by direct-to-consumer promotional activity including print, telemarketing and web-based media. As part of the agreement, ICN is making a significant prepayment of royalties at signing. Senetek’s original
license agreement with ICN was signed in October 1998. 
  
 Wade Nichols, Executive
Vice President, Corporate Development of Senetek, commented, “ICN’s expanded commitment to Kinetin in the ethical channel shows the tremendous vitality of this technology alone and in combination with other proprietary active ingredients.
ICN took the lead in 1999 in promoting Kinetin to a very discerning audience, dermatologists, and this new agreement adds exciting new dimensions to its franchise worldwide.” 
  
 Senetek’s patented ingredient, Kinetin, is a naturally occurring cytokinin that has proven to be effective in treating the appearance
of aging skin with minimal side effects. Senetek’s ten other licensees include Revlon Inc. and The Body Shop, which have successfully introduced Kinetin in their respective channels of distribution. 
  
 Visit Senetek PLC’s web site:
http://www.senetekplc.com. 
  
 Senetek PLC Investor
Relations Contact: 
 1-707-226-3900 ext. 102 
 E-Mail: Pknopick@eandecommunications.com 
  
 Safe Harbor Statement: 
  
 This news release may contain statements that
may be considered “forward- looking statements” within the meaning of the Private Securities Litigation Reform Act, including the Company’s expectation about the success of new product offerings. Forward-looking statements by their
nature involve substantial uncertainty, and actual results may differ materially from those expressed in such statements. Important factors identified by the Company that it believes could result in such material differences are described in the
Company’s Annual Report on Form 10-K for the year 2002. However, the Company necessarily can give no assurance that it has identified all of the factors that may result in any particular forward-looking statement materially differing from
actual results, and the Company assumes no obligation to correct or update any forward-looking statements which may prove to be inaccurate, whether as a result of new information, future events or otherwise. 
  

 29

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