Document:

Exhibit
10.12

 

GUARANTY

 

In
consideration of Knight Therapeutics Inc. (the "Lender") lending to Ember Therapeutics, Inc. ("Ember")
, the amount of $1,000,000 pursuant to a loan agreement, dated as of August 3, 2015, (as amended, restated or supplemented
from time to time, the "Loan Agreement");

 

Mariel
Therapeutics Inc. (the "Guarantor") hereby irrevocably, absolutely and unconditionally  guarantees (the "Guaranty")
to Lender, upon the terms and conditions hereinafter provided, the due and punctual payment, observance and performance when
due of all present and future obligations and indebtedness, of any and every kind and nature, of Ember to the Lender arising under
the Loan Agreement and the other Loan Documents, whether now or hereafter existing, whether now due or to become due, whether
primary, secondary, direct, indirect, absolute, contingent or otherwise (including without limitation, obligations of performance),
 whether several or joint or joint and several, including amounts that would become due but for the operation of a stay under
any law relating to bankruptcy, insolvency or restructuring or affecting creditors' rights (including all such amounts which would
become due but for the operation of the automatic stay with respect to Ember pursuant to Section 362(a) of the United States
Bankruptcy Code (the "Guaranteed Obligations"), and in accordance with their respective terms, and the Guarantor
expressly agree so to pay, observe or perform the same when so due or deemed to be due, upon demand therefor by the Lender which
will only be

presented
to the Guarantor following an Event of Default that is continuing . In the event that the Guaranteed Obligations are not timely
paid or performed in full, Guarantor acknowledges and agrees that (i) any payments by Ember thereafter to Lender or (ii) collections
from collateral securing the Loan shall be credited to payment of the Obligations (as defined in the Loan Agreement). The capitalized
words and expressions, wherever used in this Guaranty, unless otherwise defined herein or unless there be something in the subject
or the context inconsistent therewith, will have the meanings ascribed thereto in the Loan Agreement.

 

1.Renewal
or Extension. This Guaranty shall continue to be effective notwithstanding any renewal or extension of time of payment hereunder.

 

2.  Nature
of Guaranty. This Guaranty is a guarantee of payment and not of collectability. The Guarantor's liability hereunder is absolute,
independent and unconditional. In the event of default in payment by Ember or the Guarantor under the Guaranteed Obligations,
the Guarantor's liability hereunder shall constitute an immediate, direct and primary obligation and shall not be contingent upon
Lender's exercise or enforcement of any remedy available against Ember, the Guarantor or any other person (including any other
guarantors). Any amount payable by the Guarantor under this Guaranty which is not paid forthwith upon demand therefor will bear
interest from the date of such demand until paid in full at the rate or rates applicable to the corresponding Guaranteed Obligation
under the Loan Agreement. The Guarantor will not enforce
any right that it may at any time have against Ember or any other guarantor or any collateral for any of the Guaranteed Obligations,
including, but not limited to, rights of subrogation, exoneration, reimbursement and contribution and whether arising by operation
of law or otherwise, until all of the Guaranteed Obligations have been paid, observed and performed in full, except that this
Section 2 will not apply to routine acts, such as the giving of notices and the filing of continuation statements, necessary to
preserve any such rights. Save and except for the receipt by the Lender of the full, final and definitive amount of its
claim against Ember, with respect to the Guaranteed Obligations, the obligations of the Guarantor hereunder will not be reduced,
limited or terminated, nor will the Guarantor be discharged from any obligation hereunder, for any reason whatsoever. The Guarantor
hereby waives any and all defences related to the Guaranteed Obligations save and except for the receipt by the Lender of the
full, final and definitive amount of its claim against Ember with respect to the Guaranteed Obligations.

    	 	1	 

     

    

 

3. 
Governing Law. This Guaranty shall be governed by, and construed in accordance with, the laws of the State of New York.
All Actions arising out of or relating to this Guaranty shall be heard and determined exclusively in the United States District
Court for the District of New York; provided, however, that if such federal court does not have jurisdiction over such Action,
such Action shall be heard and determined exclusively in any New York state court. Consistent with the preceding sentence, the
parties hereby (a) submit to the exclusive jurisdiction of any federal or state court sitting in New York for the purpose of any
Action arising out of or relating to this Guaranty brought by any party hereto and (b) irrevocably waive, and agree not to assert
by way of motion, defense, or otherwise, in any such Action, any claim that it is not subject personally to the jurisdiction of
the above-named courts, that its property is exempt or immune from attachment or execution, that the Action is brought in an inconvenient
forum, that the venue of the Action is improper, or that this Guaranty or the transactions contemplated by this Guaranty may not
be enforced in or by any of the above-named courts. For the purposes of this Section 3, "Action" means any claim, cause
of action, suit, arbitration, complaint, criminal prosecution, demand, summons, citation, notice of violation, governmental or
other proceeding or investigation of any nature, civil, criminal, administrative, regulatory or otherwise, whether at law or equity.

 

4. Term.
This Guaranty shall continue until the Guaranteed Obligations have been paid and performed in full.

 

5. Waiver.
Waiver by Lender of any breach of this Guaranty or the failure of Lender to exercise any right hereunder, or any right contained
in any instrument relating to an obligation guaranteed hereunder, shall not be deemed to be a waiver of any breach or right. The
failure of any party to take action by reason of any such breach or to exercise any such right, shall not deprive such party of
the right to take action at any time while such breach, or conditions giving rise to such right, continues or recurs.

 

6. Written
Waiver. No waiver or modification of this Guaranty, or any covenant, condition or limitation herein contained, shall be valid,
unless in writing and duly executed by Lender.

 

7.  Severability.
All agreements and covenants contained herein are severable, and in the event of any of them shall be held to be invalid by any
competent court, this contract shall be interpreted as if such invalid agreements or covenants were not contained herein.

 

[Signature
page follows]

    	 	2	 

     

    

 

IN
WITNESS WHEREOF, intending to be bound, the undersigned Guarantor has executed this Guaranty as of this 3rd day of August,
2015.

 

	MARIEL THERAPEUTICS, INC.	 
	 	 
	Signature: /s/ Joseph Hernandez	 
	By: Joseph Hernandez	 
	Title: Executive Chairman	 
	 	Accepted and agreed:
	 	 
	 	KNIGHT THERAPEUTICS INC.
	 	 
	 	Signature: /s/ Jeffrey Kadanoff
	 	By: Jeffrey Kadanoff
	 	Title: CFO

 

Signature
Page to Guarantee

    	 	3Exhibit
10.13 

 

INTERCREDITOR
AND SUBORDINATION AGREEMENT

 

THIS
INTERCREDITOR AND SUBORDINATION AGREEMENT dated as of August 3, 2015 (as amended, restated or supplemented from time to time,
this "Agreement")

 

BETWEEN:STRYKER
BIOTECH L.L.C
        (together
with its successors or assigns hereinafter, "Stryker Bio")

 

AND:STRYKER
CORPORATION

   (together
with its successors or assigns hereinafter, "Stryker Corp.," and together with Stryker Bio, "Stryker")

 

AND:KNIGHT
THERAPEUTICS INC.

   (together
with its successors or assigns hereinafter, "Knight")

 

AND:EMBER
THERAPEUTICS, INC.

    (together
with its successors or assigns hereinafter, the "Debtor")

 

AND:MARIEL
THERAPEUTICS, INC.

    (together
with its successors or assigns hereinafter, "Mariel")

 

WHEREAS
pursuant to an asset purchase agreement by and among Stryker and Mariel, dated as of June 30, 2014 (as amended by that certain
Amendment No. 1 to Asset Purchase Agreement, dated July 18, 2014, that certain Amendment No. 2 to Asset Purchase Agreement, dated
August 4, 2014, and as further amended, restated or supplemented from time to time, the "Stryker APA"), Mariel acquired
the Purchased Assets (as such term is defined in the Stryker APA) from Stryker Bio for an upfront purchase price of $1,500,000
(the "Upfront Purchase Price");

 

WHEREAS
the Stryker APA also provided for additional consideration payable by Mariel to Stryker in the form of development milestone payments,
commercial milestone payments and contingent payments (collectively, the "Additional Payments");

 

WHEREAS
the Stryker APA provided that a portion of the Upfront Purchase Price would be paid by the delivery by Mariel to Stryker Bio.
of a secured promissory note in the original principal amount of $500,000 (as amended, restated or supplemented from time to time,
the "Prior Stryker Secured Note");

 

WHEREAS
pursuant to the Prior Stryker Secured Note, as security for the payment of principal, interest, and other obligations under the
Prior Stryker Secured Note, Mariel granted to Stryker Biotech a security interest in the certain collateral;

    	 	1	 

    	 	 	 

    

  

WHEREAS
on March 11, 2015, Mariel, Ember Acquisition Corp. ("Ember Acquisition") and the Debtor executed an Agreement and Plan
of Merger, pursuant to which Ember Acquisition merged into the Debtor and the Debtor became a wholly owned subsidiary of Mariel;

 

WHEREAS
pursuant to that certain Second Amended and Restated Secured Promissory Note, dated as of August 3, 2015 (as amended, restated
or supplemented from time to time, the "A&R Stryker Secured Note"), the Prior Stryker Secured Note was amended and
restated to add the Debtor as an obligor and to increase the principal amount to include certain obligations under the Stryker
APA;

 

WHEREAS
obligations under the A&R Stryker Secured Note (collectively, the "Subordinated Obligations") are secured by security
interests in substantially all of the assets of the Debtor and Mariel (collectively, the "Collateral") as security for
the Subordinated Obligations;

 

WHEREAS
pursuant to that certain Personal Guaranty dated as of August 3, 2015 (as amended, restated or supplemented from time to time,
the "Guaranty") Joseph Hernandez ("Hernandez") provided Stryker with an unconditional guaranty of the prompt
payment when due of $500,000 of the Subordinated Obligations;

 

WHEREAS
pursuant to that certain Loan Agreement, dated as of August 3, 2015 (the "Knight Loan Agreement"), Knight made a loan
to the Debtor in the aggregate principal amount of $1,000,000;

 

WHEREAS
pursuant to that certain Security Agreement, dated as of August 3, 2015 (the "Knight Security Agreement"), the Debtor
and Mariel granted to Knight a security interest in the Collateral as security for the obligations under the Knight Loan Agreement;

 

WHEREAS
the parties wish to set out how the Collateral will be dealt with in the event of a default under the Knight Loan Agreement or
the A&R Stryker Secured Note;

 

WHEREAS
Stryker has agreed that the Subordinated Obligations will be subordinated to the Senior Obligations;

 

THE
PARTIES AGREE AS FOLLOWS:

 

ARTICLE
1- INTERPRETATION

 

1.01
Definitions

 

Terms
which are not otherwise defined in this Agreement (including the recitals above), shall have the following meanings:

 

"BMP-7"
means the 13 grams of Bone Morphogenic Protein which forms part of the Collateral.

 

"Business
Day" means a day (other than Saturday or Sunday) on which banks are generally open for business in Montreal, Quebec and New
York, New York.

    	 	2	 

    	 	 	 

    

 

 

"Liens"
means any mortgage, debenture, pledge, hypothec, lien, charge, assignment by way of security, consignment, capital lease, hypothecation,
security interest or other security agreement, trust or arrangement having the effect of security for the payment of any debt,
liability or obligations.

 

"Senior
Lien" means a Lien granted by the Debtor and Mariel to Knight pursuant to the Knight Security Agreement to secure the Senior
Obligations.

 

"Senior
Obligations" means a principal amount not to exceed $1,000,000, plus interest and attorneys' fees and costs under the Knight
Loan Agreement.

 

"Subordinated
Lien" means a Lien granted by the Debtor and Mariel to Stryker pursuant to the A&R Stryker Secured Note to secure the
Subordinated Obligations. 

ARTICLE
2 - SUBORDINATION

 

		2.01	Subordination

 

Stryker
acknowledges and agrees that (i) the Subordinated Liens are subordinate to the Senior Liens and (ii) payment of the Subordinated
Obligations, whether in whole or in part, is postponed to the prior payment in full of all the Senior Obligations. Notwithstanding
anything in the Stryker APA or the A&R Stryker Secured Note to the contrary, neither the Debtor nor Mariel shall make, and
Stryker shall not accept, any payment of any of the Subordinated Obligations until after payment and satisfaction in full of any
and all of the Senior Obligations, except as expressly permitted by this Agreement. For the avoidance of doubt and notwithstanding
anything herein to the contrary, obligations owed to Stryker pursuant to the Guaranty and any Liens or other security now or hereafter
granted by Hernandez to secure the Guaranty shall not be subordinated to the Senior Liens or the payment of any of the Senior
Obligations.

 

		2.02	Amounts
                                         Outstanding

 

Stryker
hereby represents that (i) $1,013,216.44 principal amount is owing under the A&R Stryker Secured Note, (ii) obligations in
respect of the Upfront Purchase Price and the Prior Stryker Secured Note have been incorporated into the A&R Stryker Secured
Note, and (iii) no amount is currently owing under the Stryker APA, including with respect to the Additional Payments.

 

		2.03	Enforcement
                                         Standstill

 

Until
payment in full of all the Senior Obligations (unless Stryker has purchased the Senior Obligations pursuant to Section 4.03 below),
and except in connection with actions during the Initial Standstill Period, Stryker will refrain from making demand of the Debtor
or Mariel for payment of the Subordinated Obligations or exercising any rights for the enforcement of payment of the Subordinated
Obligations against the Debtor or Mariel, without the prior written consent of Knight.

    	 	3	 

    	 	 	 

    

  

		2.04	Related
                                         Undertakings

 

Until
payment in full of all the Senior Obligations (unless Stryker has purchased the Senior Obligations pursuant to Section 4.03 below),
Stryker agrees to hold as agent for Knight and forthwith remit to Knight any sum received from the Debtor or Mariel to be applied
in accordance with the Knight Loan Agreement. 

ARTICLE
3- CESSION OF RANK

 

		3.01	Cession

 

Stryker
hereby cedes and grants a priority of rank over and hereby subordinates the Subordinated Liens to the Senior Liens and acknowledges
that the Senior Liens shall have priority over the Subordinated Liens so that for all legal purposes the Senior Liens shall be
deemed to have been executed and registered prior to the execution and registration of the Subordinated Liens.

 

		3.02	Validity

 

The
cession of priority of rank and subordination granted in favour of Knight hereunder in respect of the Debtor or Mariel is valid,
binding and enforceable in all circumstances, notwithstanding:

 

		(a)	the
                                         date of the execution, the taking of effect, the registration, publication, attachment,
                                         perfection, substitution or renewal of the A&R Stryker Secured Note or the Knight
                                         Security Agreement;

 

		(b)	the
                                         date of any loan agreement or other credit or financing agreement or any offer of same
                                         among Stryker, Knight, the Debtor and/or Mariel;

 

		(c)	the
                                         date of the occurrence of any default by the Debtor or Mariel pursuant to the underlying
                                         indebtedness to Stryker or Knight; and

 

		(d)	any
                                         priority recognized by any applicable law including the Uniform Commercial Code or any
                                         other law governing the pledge or granting of a security interest in the Collateral.

 

ARTICLE
4- STANDSTILL AND COOPERATION

 

		4.01	Event
                                         of Default

 

If
an event of default shall have occurred and be continuing pursuant to the A&R Stryker Secured Note (a "Stryker Event
of Default") or if an event of default shall have occurred and be continuing under the Knight Security Agreement (a "Knight
Event of Default"), neither Stryker nor Knight shall, without the written consent of the other party, be entitled to:

    	 	4	 

    	 	 	 

    

  

		(a)	petition
                                         the Debtor or Mariel into bankruptcy or initiate or participate in the initiation of
                                         any similar proceeding;

 

		(b)	commence
                                         or initiate any action or proceeding against the Debtor or Mariel to recover or receive
                                         payment of its respective indebtedness;

 

		(c)	commence
                                         or initiate or exercise any recourse under its respective security agreement granted
                                         by the Debtor or Mariel;

 

		(d)	demand
                                         payment of indebtedness from the Debtor or Mariel or institute action against the Debtor
                                         or Mariel in connection therewith, unless the procedures set forth in Sections 4.02,
                                         4.03, and 4.04 below are complied with.

 

		4.02	Realization
                                         Proceedings

 

In
the event of the occurrence of either a Stryker Event of Default or a Knight Event of Default, Stryker will be given the opportunity
for a period of six months from the date of notice by Stryker to Knight or by Knight to Stryker of the occurrence of such event
of default (the "Initial Standstill Period") to engage in efforts to realize value from the Collateral and the business
of the Debtor or Mariel through its knowledge of the industry and the potential acquirers of the Collateral in order to maximize
the possibility of recovering the outstanding sums under the Knight Loan Agreement and under the A&R Stryker Secured Note
and the Debtor, Mariel, and Knight will cooperate with such efforts. During the Initial Standstill Period, Stryker will be responsible
for the payment the following costs ("Standstill Period Costs"): (1) costs other than those specified in (2), (3) and
(4) below in this sentence that are directly related to the conservation, preservation and maintenance of the Collateral in an
aggregate amount not to exceed $50,000 during the Initial Standstill Period ("Capped Costs") plus (2) costs directly
related to the maintenance/annuity payments (but not the prosecution or litigation) of patents owned by the Debtor and Mariel;
plus (3) storage costs of the bone morphogenic protein and cell lines owned by the Debtor and Mariel; plus (4) reasonable casualty
insurance premium costs, if any, for policies currently in effect with respect to the Collateral directly related to the conservation
and preservation of the Collateral. Standstill Period Costs shall only include those costs incurred during the Initial Standstill
Period and shall in no event include any costs generated prior to the Initial Standstill Period; provided, however, that at any
point during the Initial Standstill Period, by written notice to Knight, Stryker can elect to terminate the Initial Standstill
Period and cease to pay any Standstill Period Costs incurred on or after the date of such written notice; and, provided further,
that, if the Capped Costs exceed $50,000 during the Standstill Period, (i) Knight may, by written notice to Stryker specifying
in detail the amount of itemized Capped Costs that are unpaid, elect to terminate the Initial Standstill Period effective ten
(10) days after the giving of such notice, and (ii) the Initial Standstill Period will terminate in accordance with such notice
unless Stryker within such ten (10) day period has agreed in a written notice to Knight to pay such specified costs.

 

In
the event of the Debtor's insolvency, reorganization or any case or proceeding under any bankruptcy or insolvency law or laws
relating to the relief of debtors, unless Stryker has purchased the Senior Obligations as provided herein, this Agreement shall
remain in full force and effect, and the Senior Obligations shall be paid in full before any payment is made to Stryker.

    	 	5	 

    	 	 	 

    

 

		4.03	Standstill

 

During
the Initial Standstill Period, Stryker shall keep Knight reasonably informed of the process, the prospects of realization of value
from Collateral and the status of any potential offers to purchase the Collateral. Stryker will provide to Knight, on a timely
basis, copies of any written offers received for the purchase of all or any part of the Collateral. Provided that the amounts
owing under the Knight Loan Agreement shall be fully repaid pursuant to the conclusion of any such offer, Stryker shall have full
and complete authority to manage any such sale process as long as such sale is substantially on the same terms and conditions
as those presented to Knight.

 

Stryker
shall have the option, at any time during the Initial Standstill Period so long as any Senior Obligations remaining outstanding,
to purchase all (but not less than all) of the Senior Obligations from Knight by delivering a written notice (the "Purchase
Notice") to Knight that

(i)
states that Stryker is irrevocably electing to purchase the Senior Obligations and (ii) designates a purchase date, which shall
not be less than three (3) Business Days, nor more than ten (10) Business Days, after the receipt by Knight of the Purchase Notice
(the "Purchase Date") on which the purchase will occur. On the Purchase Date, Knight shall sell to Stryker, and Stryker
shall purchase from Knight, the Senior Obligations for a price equal to principal, plus accrued and unpaid interest on the Senior
Obligations.

 

		4.04	End
                                         of Initial Standstill Period

 

In
the event Stryker does not elect to exercise its realization proceeding rights under Section 4.02 or at the end of the Initial
Standstill Period, whether by expiration or termination by Stryker, there remains any outstanding Senior Obligations and Stryker
has not purchased such outstanding Senior Obligations pursuant to Section 4.03 above, Knight shall thereafter assume full responsibility
over the realization proceedings and shall control and supervise any sale of the Collateral and will have full and complete authority
to sell the Collateral, or any part thereof, and apply the proceeds to first pay off any such outstanding Senior Obligations,
plus all costs and expenses incurred to date, and then to pay any amounts outstanding under the A&R Stryker Secured Note.

ARTICLE
5 - GENERAL PROVISIONS

 

		5.01	Applicable
                                         Law

 

This
Agreement is governed by the laws of the State of New York.

 

		5.02	Obligations
                                         Not Reduced ; No Third Party Beneficiaries

 

Each
of the Debtor and Mariel acknowledges that this Agreement does not reduce or otherwise affect any of Senior Obligations or the
any of the Subordinated Obligations. Neither the Debtors nor Mariel is a third party beneficiary of this Agreement.

    	 	6	 

    	 	 	 

    

  

		5.03	Survival

 

The
cession of priority of rank and subordination granted in favour of Knight under the terms hereof shall continue to apply in respect
of any security obtained by Knight as a renewal, replacement, amendment or modification of the Knight Loan Agreement or the Knight
Security Agreement.

 

		5.04	No
                                         Waiver

 

The
exercise by Knight or Stryker of any of its respective rights under this Agreement does not preclude it from exercising any other
such right. In addition, any failure to exercise any such right will not constitute a renunciation to the subsequent exercise
of such right.

 

		5.05	Successors
                                         and assigns

 

The
provisions of this Agreement will be binding upon and inure to the benefit of Knight or Stryker and their respective successors
and assigns.

 

		5.06	Notices

 

Unless
otherwise provided, any notice to be given to a party in connection with this Agreement will be given in writing and will be given
by personal delivery, by a reputable delivery service, by fax or by electronic mail, addressed to the recipient at the following
addresses or at such other address as may be notified by such party to the others pursuant to this Section:

 

If
to Knight:

 

Knight
Therapeutics inc.

376
Victoria Avenue, Suite 220

Westmount,
Quebec H3Z 1C3

Attention
: Jeffrey Kadanoff

email:
jkadanoff@gud-knight.com

 

If
to Stryker Bio:

 

StrykerBiotech
L.L.C.

One
Broadway, 14th Floor

Cambridge,
MA 62142

Attention:
James Kemler, CEO

email:
jamie.kemler@stryker.com

    	 	7	 

    	 	 	 

    

 

 

If
to Stryker Corp.:

 

Stryker
Corporation

2825
Airview Blvd.

Kalamazoo,
MI 49002

Attention:
General Counsel

email:
michael.hutchinson@stryker.com

 

If
to the Debtor:

Mariel
Therapeutics, Inc.

135
East 57th Street

New
York, NY 10022

Attention:
Joseph Hernandez

email:
hernandez_joe@yahoo.com

 

If
to Mariel:

 

Mariel
Therapeutics, Inc.

135
East 57th Street

New
York, NY 10022

Attention:
Joseph Hernandez

email:
hernandez_joe@yahoo.com

 

Any
notice given by personal delivery or by a delivery service will be conclusively deemed to have been given at the time of such
delivery and, if given by telecopier or by electronic mail, on the day of transmittal if before 3:00 p.m. on a Business Day, or
on the following Business Day if such transmission occurs on a day which is not a Business Day or after 3:00 p.m. on a Business
Day. If the telecopy or electronic transmission system suffers any interruptions by way of a strike, slow-down, a force majeure,
or any other cause, a party giving a notice must do so using another means of communication not affected by the disruption. 

 

 

[Execution
page follows]

    	 	8	 

    	 	 	 

    

  

IN
WITNESS WHEREOF, the parties have signed this Agreement:

 

	KNIGHT
                            THERAPEUTICS INC.

                             

                            per:
                            /s/ Jeffrey Kadanoff

                            Name:
                            Jeffrey Kadanoff

                            Title: CFO

	 
	STRYKER
        BIOTECH L.L.C.

         

        per:
        /s/ James Kemler

        Name:
        James Kemler

        Title:
        CEO

	 
	STRYKER
        CORPORATION

         

        per:
        /s/ Jeanne M. Blondia

        Name:
        Jeanne M. Blondia

        Title:
        VP, Finance & Treasurer

	 
	EMBER
        THERAPEUTICS, INC., solely for purposes of Sections 2.01, 4.02 and 5.02

         

        per:
        /s/ Joseph Hernandez

        Name:
        Joseph Hernandez

        Title:
        Executive Chairman

	 
	MARIEL
        THERAPEUTICS, INC., solely for purposes of Sections 2.01, 4.02 and 5.02

         

        per:
        /s/ Joseph Hernandez

        Name:
        Joseph Hernandez 

        Title:
        Executive Chairman

        

 

[Signature
Page to Intercreditor and Subordination Agreement]

    	 	9

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