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                                                                   EXHIBIT 10.11

                       RESTRICTED STOCK PURCHASE AGREEMENT
                                 (Alan L. Crane)

     This Restricted Stock Purchase Agreement dated as of March 15, 2002 (this
"Agreement") is made by and between Mimeon, Inc., a Delaware corporation (the
"Company"), and Alan L. Crane (the "Purchaser").

     1.   DEFINITIONS. As used in this Agreement, the following terms shall have
the following meanings:

          DISABILITY: The inability of Purchaser to substantially perform his
duties to the Company as a result of Purchaser's incapacity due to illness or
physical disability.

          PERMANENT DISABILITY: A Disability which continues for at least 120
consecutive calendar days or 150 calendar days during any consecutive
twelve-month period, after its commencement, and is determined in good faith to
be total and permanent by the Board of Directors following consultation with
reputable medical or health experts selected by the Board of Directors.

          QUALIFIED OFFERING: A firm commitment underwritten public offering of
the Company's Common Stock pursuant to an effective registration statement under
the Securities Act of 1933, as amended (the "Act"), in which the price per share
is at least $5.00 (subject to equitable adjustment in the event of stock splits
and the like) and the aggregate gross proceeds to the Company from such offering
are not less than $10,000,000.

          QUALIFIED SALE: The sale of all or substantially all of assets or
issued and outstanding capital stock of the Company, or merger or consolidation
involving the Company in which stockholders of the Company immediately before
such merger or consolidation do not own immediately after such merger or
consolidation capital stock or other equity interests of surviving corporation
or entity representing more than fifty percent in voting power of capital stock
or other equity interests of such surviving corporation or entity outstanding
immediately after such merger or consolidation.

          SERVICE: Service as an employee, officer or director of, or a
consultant or advisor to, the Company or its successors.

          SHARES: The shares of Common Stock issued to Purchaser hereunder and
any other securities of the Company which may be issued in exchange for or in
respect of such shares of Common Stock, whether by way of stock split, stock
dividend, combination of shares, reclassification, recapitalization,
reorganization or any other means.

          UNVESTED SHARES: Any Shares that are not Vested Shares.

          VESTED: Released from the Company's Repurchase Option (as defined in
Section 5(a)).

          VESTED SHARES: Any Shares that have vested in accordance with
Section 5(b).

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     2.   PURCHASE AND SALE OF SHARES. The Company hereby sells to Purchaser,
and Purchaser hereby purchases from the Company, 766,296 shares of the Company's
common stock, $0.0001 par value per share ("Common Stock"), for a purchase price
per share of $0.0001, and an aggregate purchase price of $76.63. Purchaser and
the Company hereby agree that the fair market value of the Shares on the date
hereof is $0.17 per share.

     3.   REPRESENTATIONS OF PURCHASER. Purchaser understands that the Shares
are not registered under the Act, and represents to the Company, and agrees that
the Company is entitled to rely on such representations, as follows:

          (a)  Purchaser understands that the Shares have not been registered
under the Act, or registered or qualified under the securities or "Blue Sky"
laws of any jurisdiction, and are being sold pursuant to exemptions contained in
the Act and exemptions contained in other applicable securities or "Blue Sky"
laws. Purchaser understands further that the Company's reliance on these
exemptions is based in part on the representations made by Purchaser in the
Agreement. In this connection, Purchaser represents and warrants that the offer
and sale of the Shares were made solely in Massachusetts.

          (b)  Purchaser understands the term "accredited investor" as used in
Regulation D promulgated under the Act and represents and warrants to the
Company that he is an "accredited investor" for purposes of acquiring the
Shares. The nature and amount of Purchaser's investment in the Shares is
consistent with Purchaser's investment objectives, abilities, and resources.
Purchaser understands that the Shares are an illiquid investment, which will not
become freely transferable by reason of any "change of circumstances" whatever.
Purchaser has adequate means of providing for Purchaser's current needs and
possible contingencies and has no need for liquidity in Purchaser's investment.

          (c)  Purchaser is acquiring the Shares for Purchaser's own account for
investment, and not for, with a view to, or in connection with the resale or
distribution thereof. Purchaser has no present intention to sell, hypothecate,
distribute or otherwise transfer the Shares or any portion thereof or any
interest therein.

          (d)  Purchaser understands that the Shares will constitute "restricted
securities" within the meaning of Rule 144 promulgated under the Act and that,
as such, the Shares must be held indefinitely unless they are subsequently
registered under the Act or unless an exemption from the registration
requirements thereof is available. Purchaser has been advised that Rule 144,
which permits the resale, subject to various terms and conditions, of small
amounts of such "restricted securities" after they have been held for one year,
does not now apply to the Company, because the Company is not now required to
file, and does not file, current reports under the Securities Exchange Act of
1934, and because information concerning the Company substantially equivalent to
that which would be available if the Company were required to file such reports
is not now publicly available. The Company may become a reporting entity at some
future date, but no assurance can be given that it will do so.

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          (e)  In connection with Purchaser's acquisition of the Shares,
Purchaser accepts the condition that the Company may maintain "stop transfer"
orders with respect to the Shares and that each certificate or other document
evidencing the Shares will bear conspicuous legends in substantially the form
set forth in Section 7 of this Agreement.

          (f)  Purchaser has consulted Purchaser's attorney or accountant with
respect to Purchaser's purchase of the Shares. Purchaser has fully investigated
the Company and its business and financial condition and has knowledge of the
Company's current activities. Purchaser acknowledges that the Company has
granted Purchaser and Purchaser's attorney or accountant access to all
information about the Company which they have requested and has offered each of
them access to all further information which they deemed relevant to an
investment decision with respect to the Shares. Purchaser and Purchaser's
attorney or accountant have had the opportunity to ask questions of, and receive
answers from, representatives of the Company concerning such information and the
Company's financial condition and prospects.

     4.   RESTRICTIONS ON TRANSFER. The following restrictions on transfer of
the Shares shall apply:

          (a)  SECURITIES LAWS. Except for purchases of Unvested Shares by the
Company as contemplated by Section 5, no Shares, nor any interest therein, may
be sold, assigned, pledged or otherwise transferred at any time or under any
circumstances unless (i) the Shares proposed to be transferred have been
registered under the Act and qualified under applicable state securities laws,
or (ii) the Company has received, or agreed to waive, an opinion of counsel
acceptable to the Company to the effect that such transfer may be effected
without registration under the Act or qualification under the securities laws of
relevant states and the proposed transferee has made such representations and
agreements as the Company shall require to assure compliance with the Act and
such laws.

          (b)  TERMINATION OF REPURCHASE OPTION. Except for purchases of
Unvested Shares by the Company as contemplated by Section 5, no Shares, nor any
interest therein, may be sold, assigned, pledged or otherwise transferred until
the Repurchase Option shall have terminated with respect to such Shares.

          (c)  RIGHT OF FIRST OFFER. In the event that at any time Purchaser
desires to sell, assign or otherwise transfer any of the Vested Shares then held
by Purchaser, he shall first offer the Vested Shares desired to be transferred
to the Company by giving written notice of the proposed transfer. The notice
shall state the number of Vested Shares proposed to be transferred, the name of
the person or persons to whom it is proposed to transfer the Vested Shares, the
price at which the Vested Shares are intended to be transferred and all other
terms of the transaction, which must be bona fide. Such notice shall constitute
an offer by Purchaser to the Company for the Company to purchase such Vested
Shares on such terms and at a price per Vested Share equal to the price stated
in the notice. The Company may accept the offer as to all, but not less than
all, of the Vested Shares offered by notifying Purchaser in writing within 30
days after receipt of such notice of its acceptance of the offer. If the offer
is accepted, Purchaser shall sell the offered Vested Shares to the Company on
the terms and at the price per Vested Share as

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aforesaid, free of all encumbrances, and shall deliver the certificates
representing such Vested Shares, duly endorsed in blank by Purchaser or with
duly executed stock powers attached thereto, all in form suitable for the
transfer of such Vested Shares to the Company, within 30 days of the date of
acceptance of the offer to sell, against payment therefor at the same price per
Vested Share and according to the same terms as were offered by the proposed
transferee. If within the applicable time period Purchaser does not receive
notice of the Company's intention to purchase the offered Vested Shares, the
offer shall be deemed to have been rejected. In such event, Purchaser may
transfer title to the offered Vested Shares within 90 days from the date of his
written notice to the Company of his intention to sell, but such transfer shall
be made only to the proposed transferee or transferees and at the proposed price
and on such other terms as stated in such notice. Vested Shares that are so
transferred to such transferee or transferees shall remain subject to this
Section 3 and as a condition to any transfer Purchaser shall obtain a written
agreement from the transferee by which the transferee agrees to be bound by this
Section 3.

          (d)  PERMITTED TRANSFERS. Any portion or all of the Vested Shares may,
without compliance with the provisions of Section 4(c), be transferred by
Purchaser: (i) to his spouse, his parents and the linear descendants of his
parents (collectively, "family members"); (ii) to a trust established for the
benefit of his family members; (iii) under his will or otherwise pursuant to the
laws of descent and distribution; (iv) to a partnership, limited liability
company or other entity controlled by Purchaser, the partners or members of
which consist solely of Purchaser, his spouse and/or any of his other family
members; or (v) to a charitable organization or educational institution
qualifying for exemption from Federal income taxes pursuant to Section 501(c)(3)
of the Internal Revenue Code of 1986, as amended (the "Code"); provided,
however, that Shares that are so transferred shall remain subject to this
Section 4 and as a condition to any transfer Purchaser (or Purchaser's estate)
shall obtain a written agreement from the transferee by which the transferee
agrees to be bound by this Section 4.

          (e)  REMEDIES. No sale, assignment, pledge or other transfer of Shares
shall be effective or given effect on the books of the Company unless all of the
applicable provisions of this Section 4 have been duly complied with. If any
transfer of Shares is made or attempted in violation of the foregoing
restrictions, or if Shares are not offered to the Company as required hereby,
the Company shall have the right to purchase such Shares from the purported
owner thereof or his transferee at any time before or after the transfer, as
herein provided. In addition to any other legal or equitable remedies which it
may have, the Company may enforce its rights by actions for specific performance
(to the extent permitted by law) and may refuse to recognize any transferee as
one of its stockholders for any purpose, including, without limitation, for
purposes of dividend and voting rights, until all applicable provisions hereof
have been complied with.

          (f)  LOCK-UP. Purchaser agrees that for a period of up to 180 days
from the effective date of any registration of securities of the Company under
the Act (upon request of the Company or the underwriters managing any
underwritten offering of the Company's securities), he will not sell, make any
short sale or loan of, grant any option for the purchase of, or otherwise
dispose of any Shares held by him without the prior written consent of the
Company or such

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underwriters, as the case may be; provided, however, that all officers and
directors of the Company enter into similar agreements.

          (g)  TERMINATION OF RESTRICTIONS. Sections 4(c) and 4(d) shall
terminate upon the earlier to occur of: (i) immediately prior to the
consummation of a Qualified Sale; or (ii) the closing of a Qualified Offering.

     5.   REPURCHASE OF UNVESTED SHARES.

          (a)  REPURCHASE OPTION.

               (i)   In the event of the termination of Purchaser's Service by
Purchaser or the Company for any reason, with or without cause, the Company
shall upon the date of such termination (the "Termination Date") have an
irrevocable, exclusive option (the "Repurchase Option") for a period of 90 days
from such date to repurchase all or any portion of the Unvested Shares at the
repurchase price of $0.17 per share, appropriately adjusted in the event of a
stock dividend, stock split, recapitalization, combination of shares or similar
event occurring subsequent to the date of this Agreement.

               (ii)  Unless the Company notifies Purchaser within 90 days from
the date of termination of Purchaser's Service that it does not intend to
exercise its Repurchase Option with respect to some or all of the Unvested
Shares, the Repurchase Option shall be deemed automatically exercised by the
Company as of the 90th day following such termination, provided that the Company
may notify Purchaser that it is exercising its Repurchase Option as of a date
prior to such 90th day. Unless Purchaser is otherwise notified by the Company
pursuant to the preceding sentence that the Company does not intend to exercise
its Repurchase Option as to some or all of the Unvested Shares to which it
applies at the time of termination, execution of this Agreement by Purchaser
constitutes written notice to Purchaser of the Company's intention to exercise
its Repurchase Option with respect to all Unvested Shares to which such
Repurchase Option applies. The Company, at its choice, may satisfy its payment
obligation to Purchaser with respect to exercise of the Repurchase Option by
either (A) delivering a check to Purchaser in the amount of the purchase price
for the Unvested Shares being repurchased, or (B) in the event Purchaser is
indebted to the Company, canceling an amount of such indebtedness equal to the
purchase price for the Unvested Shares being repurchased, or (C) by a
combination of (A) and (B) so that the combined payment and cancellation of
indebtedness equals such purchase price, provided that the Company shall use
good faith efforts to satisfy its payment obligation to Purchaser within 15 days
after Company's notice of exercise of the Repurchase Option (or deemed
exercise), and that if such check is not delivered or such cancellation is not
effective within such 15 days from such date, the amount of the Company's
unsatisfied payment obligation shall bear interest at a rate of nine percent
(9%) per annum until the Company has satisfied its payment obligation under this
paragraph (ii). In the event of any deemed automatic exercise of the Repurchase
Option pursuant to this Section 5(a)(ii) and Purchaser is then indebted to the
Company, the amount of such indebtedness equal to the purchase price of the
Unvested Shares being repurchased shall be deemed automatically canceled as of
the date of Company's notice of exercise of the Repurchase Option (or deemed
exercise). As a result of any repurchase

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of Unvested Shares pursuant to this Section 5(a), the Company shall become the
legal and beneficial owner of the Unvested Shares being repurchased and shall
have all rights and interest therein or related thereto, and the Company shall
have the right to transfer to its own name the number of Unvested Shares being
repurchased by the Company, without further action by Purchaser.

          (b)  VESTING.

               (i)   The Shares will become vested as follows:

                     (A) One fourth of the Shares shall vest on March 15, 2003;
and

                     (B) an additional one forty-eighth (1/48) of the Shares
shall vest on the 15th day of each month thereafter until 100% of the Shares
have become vested; PROVIDED, however, that the vesting of Shares on any such
vesting date shall be conditioned upon Purchaser's continuing Service with the
Company from the date hereof through such vesting date. Fractional shares shall
be rounded down to the nearest whole share. Notwithstanding the foregoing, all
times at which Shares shall be released from the Repurchase Option shall be
extended in the event of a Disability by the period of Disability.

               (ii)  Notwithstanding Section 4(b)(i), (A) all Shares shall be
deemed to have vested immediately prior to the consummation of a Qualified Sale,
and (B) 33% of all Unvested Shares shall be deemed to have vested upon the death
or Permanent Disability of the Purchaser.

          (c)  CONSIDERATION FOR REPURCHASE PRICE. As consideration for a
repurchase price (see Section 5(a)) that is greater than the purchase price (see
Section 2), Purchaser agrees to make a capital contribution to the Company of
$35,528 on each of January 1, 2003, January 1, 2004 and January 1, 2005.
Notwithstanding any other provision of this Agreement, Purchaser's obligation
under this Section 5(c) shall survive the expiration or termination of this
Agreement for any reason.

     6.   CUSTODY OF CERTIFICATES. In order to facilitate the exercise of the
Repurchase Option, the Company or its counsel shall hold all certificates
representing Unvested Shares, together with an adequate number of undated and
otherwise blank stock powers executed by Purchaser. The Company shall have the
right to cause transfers of Unvested Shares to be effected pursuant to Section
5. After any Shares become Vested Shares, the Company shall, upon request of
Purchaser, deliver to Purchaser a certificate or certificates representing such
Vested Shares. After the Company sends Purchaser a notice that it does not
intend to exercise its Repurchase Option as to certain Unvested Shares, the
Company shall, upon request of Purchaser, deliver to Purchaser a certificate or
certificates representing such Unvested Shares.

     7.   LEGENDS. Each certificate representing Shares shall prominently bear
legends in substantially the following forms:

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     These securities have not been registered under the Securities Act of 1933.
     They may not be sold, offered for sale, pledged or hypothecated in the
     absence of a registration statement in effect with respect to the
     securities under such Act or an opinion of counsel satisfactory to the
     Corporation that such registration is not required.

     The securities represented by this certificate have been acquired for
     investment and have not been registered or qualified under the securities
     or "Blue Sky" laws of any jurisdiction. They may not be offered or sold
     without an opinion of counsel to the Corporation to the effect that the
     proposed transaction will be exempt from registration, qualification, and
     filings in all applicable jurisdictions.

     The Corporation is authorized to issue more than one class or series of
     stock. The powers, designations, preferences and relative participating,
     optional or other special rights, and the qualifications, limitations or
     restrictions of such preferences and/or rights of each class of stock or
     series of any class set forth in the Certificate of Incorporation of the
     Corporation. The Corporation will furnish a copy of the Certificate of
     Incorporation of the Corporation to the holder of this certificate without
     charge upon request.

     The securities represented by this certificate are subject to restrictions
     on transfer and repurchase rights pursuant to the terms of a Restricted
     Stock Purchase Agreement, as amended from time to time, between the owner
     of this certificate and the Corporation. The Corporation will furnish a
     copy of this agreement to the holder hereof without charge upon written
     request.

     8.   MISCELLANEOUS.

          (a)  Entire Agreement. This Agreement constitutes the entire agreement
between the parties with respect to the subject matter hereof, and supersedes
all prior agreements, negotiations, representations and proposals, written or
oral, relating to such subject matter.

          (b)  AMENDMENTS. Neither this Agreement nor any provision hereof may
be changed or modified except by an agreement in writing executed by Purchaser
and on behalf of the Company.

          (c)  BINDING EFFECT OF THE AGREEMENT. This Agreement shall inure to
the benefit of, and be binding upon, the Company, Purchaser and their respective
estates, heirs, executors, transferees, successors, assigns and legal
representatives.

          (d)  PROVISIONS SEVERABLE. In the event that any provision of this
Agreement shall be determined to be invalid, illegal or otherwise unenforceable
by any court of competent jurisdiction, the validity, legality and
enforceability of the other provisions of this Agreement shall not be affected
thereby. Any invalid, illegal or unenforceable provision of this Agreement

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shall be severed, and after any such severance, all other provisions hereof
shall remain in full force and effect.

          (e)  NOTICES. All notices under this Agreement shall be effective (i)
upon personal or facsimile delivery, (ii) two business days after deposit in the
United States mail as registered or certified mail postage fully prepaid, or
(iii) one business day after pickup by any overnight commercial courier service,
in each case sent or addressed to the Company at its principal office and to
Purchaser at his record address as carried in the stock records of the Company
or at such other address as he may from time to time designate in writing to the
Company.

          (f)  CONSTRUCTION. A reference to a Section shall mean a Section of
this Agreement unless otherwise expressly stated. The titles and headings herein
are for reference purposes only and shall not in any manner limit the
construction of this Agreement which shall be considered as a whole. The words
"include," "includes" and "including" when used herein shall be deemed in each
case to be followed by the words "without limitation." Whenever the context may
require, any pronouns used herein shall include the corresponding masculine,
feminine or neuter forms, and the singular form of names and pronouns shall
include the plural and vice-versa.

          (g)  NO EMPLOYMENT AGREEMENT. This Agreement shall not be construed as
an agreement by the Company to employ Purchaser, nor is the Company obligated to
employ Purchaser by reason of this Agreement or the issuance of the Shares to
Purchaser.

          (h)  SECTION 83(b) ELECTION. Purchaser will furnish to the Company a
copy of any election made by Purchaser under Section 83(b) of the Code with
respect to his acquisition of the Shares.

          (i)  APPLICABLE LAW. This Agreement shall be construed and enforced in
accordance with the laws of The Commonwealth of Massachusetts, without regard to
its principles of conflicts of laws. Purchaser consents to jurisdiction and
venue in any state or federal court in The Commonwealth of Massachusetts for the
purposes of any action relating to or arising out of this Agreement or any
breach or alleged breach hereof, and to service of process in any such action by
certified or registered mail, return receipt requested.

          (j)  DISPOSITION OF SHARES; PURCHASE BY NOMINEE OR DESIGNEE. Any
Shares that the Company elects to purchase hereunder may be disposed of by it in
such manner as it deems appropriate with or without restrictions on the transfer
thereof, and the Company may require their transfer to a nominee or designee as
part of any purchase of the Shares from Purchaser.

          (k)  WITHHOLDING TAXES. Purchaser acknowledges and agrees that the
Company has the right to deduct from payments of any kind otherwise due to
Purchaser any federal, state or local taxes of any kind required by law to be
withheld with respect to the purchase of the Shares by Purchaser.

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     IN WITNESS WHEREOF, the parties hereto have executed this Restricted Stock
Purchase Agreement as of the date first above written.

                            MIMEON, INC.

                            By: /s/ Christoph Westphal, MD PhD
                               ------------------------------------
                                Christoph Westphal
                                President and Chief Executive Officer

                            /s/ Alan L. Crane
                            -----------------------------
                            Alan L. Crane

                                        9<Page>

                                                                   EXHIBIT 10.12

                           FIRST AMENDED AND RESTATED
                              EMPLOYMENT AGREEMENT
                              (Ganesh Venkataraman)

     This First Amended and Restated Employment Agreement dated as of April 10,
2002 (this "Agreement") is made by and between Mimeon, Inc., a Delaware
corporation (the "Company"), and Ganesh Venkataraman ("Employee").

     WHEREAS, the Company and Employee and parties to Employment Agreement dated
June 13, 2001 (the "Original Employment Agreement"); and

     WHEREAS, the Company and Employee desire to amend and restate the Original
Agreement to increase Employee's compensation, to change his title and
responsibilities and to effect the other modifications set forth herein;

     NOW, THEREFORE, in consideration of the premises and the mutual covenants
and agreements herein contained, the parties hereto agree as follows:

     1.   EMPLOYMENT. The Company hereby employs Employee to perform those
duties and services as the Company shall from time to time set forth, and
Employee accepts employment with the Company, upon the terms and conditions
hereinafter set forth. Employee shall serve as a Vice President of the Company
and shall report to the Chief Executive Officer of the Company. The Chief
Executive Officer shall have the right to review and change the responsibilities
of Employee and from time to time as he or she may deem necessary or appropriate
and the Chief Executive Officer may elect, at his or her discretion, to change
the reporting relationship for Employee.

     2.   BOARD OBSERVER RIGHTS. Employee may attend all meetings (whether in
person or telephonic) of the Board and the Compensation Committee of the Board
(the "Compensation Committee") in a non-voting, observer capacity. The Company
shall provide to Employee copies of all notices, minutes, consents, and other
materials that it provides to its directors; PROVIDED, however, that Employee
shall agree to act in a fiduciary manner with respect to all information so
provided; and, PROVIDED further, that the Company reserves the right to withhold
any information and to exclude Employee from any meeting or portion thereof (i)
if access to such information or attendance at such meeting could adversely
affect the attorney-client privilege between the Company and its counsel, or
(ii) if such information or meeting relates to Employee's employment or
compensation. Notwithstanding the foregoing, the Company may revoke Employee's
rights under this Section 2 if the Board of Directors determines, in its sole
discretion, that such revocation is in the best interests of the Company.

     3.   DUTY TO PERFORM SERVICES. Employee shall devote his full time during
normal business hours to rendering services to the Company hereunder, and shall
exert all reasonable efforts in the rendering of such services. Provided
Employee is in compliance with the immediately preceding sentence (and except to
the extent the restrictions contained in Section 9 may apply), nothing in this
Agreement shall prohibit Employee from (a) making and managing passive
investments and (b) engaging in religious, academic, charitable or other
community or

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non-profit activities, including continuing his part-time involvement in the
Consortium for Functional Glycomics.

     Employee agrees that in the rendering of all services to the Company and in
all aspects of employment hereunder, he shall comply in all material respects
with all directives, policies, standards and regulations from time to time
established by the Company, to the extent they are not in conflict with this
Agreement.

     4.   TERM OF AGREEMENT. There shall be no definite term of employment, and
Employee shall be an employee at will. The Company may terminate Employee's
employment with the Company at any time with or without Cause (as defined in
Section 18(e)).

     5.   COMPENSATION.

          (a)  BASE SALARY. Commencing as of January 1, 2002, and throughout the
term of this Agreement, the Company shall pay Employee a base salary, payable in
equal installments in accordance with the Company's standard schedule for salary
payments to its employees, at an annual rate equal to $140,000. Employee's base
salary shall be reviewed by the Company at least once every 12 months and may be
increased on or after each such review as mutually agreed upon by the Company
and Employee.

          (b)  REALLOCATION OF FOUNDERS STOCK. The Company and Employee shall
enter into Reallocation of Founder Shares Agreement, substantially in the form
of EXHIBIT A, which provides for the sale of 80,000 shares, in aggregate, of the
Company's outstanding common stock, $.0001 par value per share ("Common Stock"),
from Company founders Ram Sasisekharan and Robert Langer to Employee at a price
of $.0001 per share. These 80,000 shares shall be subject to vesting in
accordance with schedule set forth in Employee's Restricted Stock Purchase
Agreement dated as of June 13, 2001.

          (c)  BONUSES.

               (i)   SIGNING BONUS. Promptly after the Company and Employee sign
this Agreement, the Company shall pay Employee a signing bonus of $15,000 in
cash

               (ii)  YEAR-END BONUS. If the performance goals set forth in
SCHEDULE A (as the same may be modified from time to time in a writing signed by
the Employee and the Employee's supervisor, the "Performance Goals") are
achieved by December 31, 2002, then the Company shall pay Employee a bonus of
$30,000 in cash by March 1, 2003; PROVIDED, however, that the Company shall pay
Employee a bonus of less than $30,000 if only some of the Performance Goals have
been achieved or if some of the Performance Goals have been partially achieved;
and PROVIDED, further, however, that the amount of the bonus may be increased by
the Chief Executive Officer, after consultation with the Compensation Committee
of the Board of Directors if appropriate, based on other considerations deemed
relevant by the Chief Executive Officer at or about the time that the bonus is
to be awarded. The determination of whether or not a Performance Goal has been
achieved shall be made by the Chief Executive Officer in his or her sole
discretion.

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     6.   VACATIONS AND HOLIDAYS; BENEFITS.

          (a)  VACATION AND HOLIDAYS. Employee shall be entitled to 15 paid
vacation days annually and shall not be required to work but shall be paid for
all major U.S. holidays.

          (b)  BENEFITS. Employee and, to the extent applicable, Employee's
family, dependents and beneficiaries, shall be entitled to receive medical and
dental insurance coverage through the Company, and such other benefits,
including 401(k) plan, life insurance and disability insurance, as may be
provided by the Company to its other similarly situated senior executives from
time to time (collectively, the "Benefits").

     7.   EXPENSES. The Company shall pay or reimburse Employee for all
reasonable business expenses incurred by Employee in connection with his
employment by the Company in accordance with the Company's policies in effect
from time to time.

     8.   CONFIDENTIAL INFORMATION. While employed by the Company and
thereafter, Employee shall not, directly or indirectly, use any Confidential
Information (as defined below) other than pursuant to his employment by and for
the benefit of the Company, or disclose any Confidential Information to anyone
outside of the Company, whether by private communication, public address,
publication or otherwise, or disclose any Confidential Information to anyone
within the Company who has not been authorized to receive such information,
except as directed in writing by an authorized representative of the Company.
The term "Confidential Information" as used throughout this Agreement shall mean
all trade secrets, proprietary information, know-how, data, designs,
specifications, processes, customer lists and other technical or business
information (and any tangible evidence, record or representation thereof),
whether prepared, conceived or developed by a consultant or employee of the
Company (including Employee) or received by the Company from an outside source,
which is in the possession of the Company (whether or not the property of the
Company) and which is maintained in confidence by the Company. Without limiting
the generality of the foregoing, Confidential Information shall include:

          (a)  any idea, improvement, invention, innovation, development,
technical data, design, formula, device, pattern, sequence, concept, art,
method, process, machine, manufacturing method, composition of matter, computer
program, software, firmware, source code, object code, algorithm, subroutine,
object module, schematic, model, diagram, flow chart, chip masking
specification, user manual, training or service manual, product specification or
design, plan for a new or revised product, sample, compilation of information,
or work in process, and any and all revisions and improvements relating to any
of the foregoing (in each case whether or not reduced to tangible form); and

          (b)  the name of any employee, consultant, customer or prospective
customer, or any other customer or prospective customer information, any sales
plan, marketing material, plan or survey, business plan or opportunity, product
or development plan or specification, business proposal, financial record, or
business record or other record or information relating to the present or
proposed business of the Company or any customer.

                                        3
<Page>

     Notwithstanding the foregoing, the term Confidential Information shall not
apply to information which the Company has voluntarily disclosed to the public
without restriction, or which has otherwise lawfully entered the public domain.

     Employee acknowledges that the Company from time to time has in its
possession information which is claimed by customers and others to be
proprietary and which the Company has agreed to keep confidential. Employee
agrees that all such information shall be Confidential Information for purposes
of this Agreement.

     9.   OWNERSHIP AND ASSIGNMENT OF INTELLECTUAL PROPERTY. Employee agrees
that all originals and all copies of all manuscripts, drawings, prints, manuals,
diagrams, letters, notes, notebooks, reports, models, records, files, memoranda,
plans, sketches and all other documents and materials containing, representing,
evidencing, recording, or constituting any Confidential Information (as defined
in Section 8 above), however and whenever produced (whether by Employee or
others) shall be the sole property of the Company.

     Employee agrees that all Confidential Information and all other
discoveries, inventions, ideas, specifications, designs, concepts, research and
other information, processes, products, methods and improvements, or parts
thereof conceived, developed, or otherwise made by him, alone or jointly with
others and in any way relating to the Company's present or proposed products,
programs or services or to tasks assigned to him during the course of his
employment, whether or not patentable or subject to copyright protection and
whether or not reduced to tangible form or reduced to practice, during the
period of his employment with the Company, whether or not made during my regular
working hours, and whether or not made on the Company's premises, and whether or
not disclosed by him to the Company (hereinafter referred to as "Intellectual
Property") together with all products or services which embody or emulate any
Intellectual Property shall be the sole property of the Company.

     Employee agrees to, and hereby does, assign to the Company all his right,
title and interest throughout the world in and to all Intellectual Property and
to anything tangible which evidences, incorporates, constitutes, represents or
records any Intellectual Property. Employee agrees that all Intellectual
Property shall constitute works made for hire under the copyright laws of the
United States and hereby assigns and, to the extent any such assignment cannot
be made at present, Employee hereby agrees to assign to the Company all
copyrights, patents and other proprietary rights Employee may have in any
Intellectual Property, together with the right to file for and/or own wholly
without restriction United States and foreign patents, trademarks, and
copyrights. Employee agrees to waive, and hereby waives, all moral rights or
proprietary rights in or to any Intellectual Property and, to the extent that
such rights may not be waived, agrees not to assert such rights against the
Company or its licensees, successors or assigns.

     Employee hereby certifies that SCHEDULE B sets forth any and all
confidential information and intellectual property that Employee claims as his
own or otherwise intends to exclude from this Agreement because it was developed
by him prior to the date of this Agreement. Employee understands that after
execution of this Agreement he shall have no right to exclude Confidential
Information or Intellectual Property from this Agreement.

                                        4
<Page>

     10.  EMPLOYEE'S OBLIGATION TO KEEP RECORDS. Employee shall make and
maintain adequate and current written records of all Intellectual Property,
including notebooks and invention disclosures, which records shall be available
to and remain the property of the Company at all times. Employee shall disclose
all Intellectual Property promptly, fully and in writing to the Company
immediately upon production or development of the same and at any time upon
request.

     11.  EMPLOYEE'S OBLIGATION TO COOPERATE. Employee will, at any time during
his employment, or after it terminates, upon request of the Company, execute all
documents and perform all lawful acts which the Company considers necessary or
advisable to secure its rights hereunder and to carry out the intent of this
Agreement. Without limiting the generality of the foregoing, Employee will
assist the Company in any reasonable manner to obtain for its own benefit
patents or copyrights in any and all countries with respect to all Intellectual
Property assigned pursuant to Section 9, and Employee will execute, when
requested, patent and other applications and assignments thereof to the Company,
or Persons (as deemed in Section 18(f)) designated by it, and any other lawful
documents deemed necessary by the Company to carry out the purposes of this
Agreement, and Employee will further assist the Company in every way to enforce
any patents and copyrights obtained, including testifying in any suit or
proceeding involving any of said patents or copyrights or executing any
documents deemed necessary by the Company, all without further consideration
than provided for herein. It is understood that reasonable out-of-pocket
expenses of Employee's assistance incurred at the request of the Company under
this Section will be reimbursed by the Company.

     12.  NONCOMPETITION. Employee agrees that during the term of this Agreement
and for a period of 12 months after the termination of this Agreement (the
"Restricted Period"), Employee shall not directly or indirectly (i) provide any
services in the Field of Interest (as defined in Section 18(e)) to any Person
other than the Company, (ii) become an owner, partner, shareholder, consultant,
agent, employee or co-venturer of any Person that has committed, or intends to
commit, significant resources to the Field of Interest.

     13.  NONSOLICITATION. During the Restricted Period, Employee shall not (i)
solicit, encourage, or take any other action which is intended to induce any
employee of, or consultant to, the Company (or any other Person who may have
been employed by, or may have been a consultant to, the Company during the term
of Employee's employment) to terminate his or her employment or relationship
with the Company in order to become employed by or otherwise perform services
for any other Person or (ii) solicit, endeavor to entice away from the Company
or otherwise interfere with the relationship of the Company with any Person who
is, or was within the then-most recent 12 month period, a client or customer of
the Company.

     14.  RETURN OF PROPERTY. Upon termination of Employee's employment with the
Company, or at any other time upon request of the Company, Employee shall return
promptly any Confidential Information, including all customer or prospective
customer lists, other customer or prospective customer information or related
materials, computer programs, software, electronic data, specifications,
drawings, blueprints, medical devices, samples, reproductions, sketches, notes,
notebooks, memoranda, reports, records, proposals, business plans, or copies of
them, other documents or materials, tools, equipment, or other property
belonging to the Company or its customers which Employee may then possess or
have under his control.

                                        5
<Page>

Employee further agrees that upon termination of his employment he shall not
take with him any documents or data in any form or of any description containing
or pertaining to Confidential Information or Intellectual Property.

     15.  OTHER OBLIGATIONS.

          (a)  Employee hereby represents, warrants and agrees (i) that Employee
has the full right to enter into this Agreement and perform the services
required of him hereunder, without any restriction whatsoever; (ii) that in the
course of performing services hereunder, Employee will not violate the terms or
conditions of any agreement between him and any third party or infringe or
wrongfully appropriate any patents, copyrights, trade secrets or other
intellectual property rights of any Person anywhere in the world; (iii) that
Employee has not and will not disclose or use during his employment by the
Company any confidential information that he acquired as a result of any
previous employment or consulting arrangement or under a previous obligation of
confidentiality; and (iv) that Employee has disclosed to the Company in writing
any and all continuing obligations to previous employers or others that require
him not to disclose any information to the Company.

          (b)  Employee acknowledges that the Company from time to time may have
agreements with other Persons, including the government of the United States or
other countries and agencies thereof, which impose obligations or restrictions
on the Company regarding inventions made during the course of work thereunder or
regarding the confidential nature of such work. Employee agrees to be bound by
all such obligations and restrictions and to take all action necessary to
discharge the obligations of the Company thereunder.

     16.  TERMINATION EVENT. The following events shall each be considered a
"Termination Event" and, upon the occurrence of any of them, shall have the
effect of immediately terminating the Company's obligations under this
Agreement, including its obligation to make any further payments hereunder but
excluding the payment of base salary and vacation benefits which are accrued at
the date of termination:

          (a)  Employee's death;

          (b)  Employee's Disability for such period of time and under
circumstances which would constitute a Long Term Disability;

          (c)  The termination of Employee's employment by the Company for Cause
(as defined in Section 18(e)). Termination pursuant to Section 16(c) shall be
without prejudice to any other right or remedy to which the Company may be
entitled, at law, in equity, under this Agreement or otherwise; or

          (d)  The termination of Employee's employment by Employee for any
reason.

     Notwithstanding Employee's termination of employment pursuant to Section
16(b), 16(c) or 16(d), Employee's covenants and obligations set forth in
Sections 8, 9, 10, 11, 12, 13 and 14 shall remain in effect and be fully
enforceable in accordance with the provisions thereof.

                                        6
<Page>

     17.  TERMINATION WITHOUT CAUSE. In addition to the other termination rights
provided to the Company or Employee hereunder, the Company may terminate
Employee's employment without Cause at any time; PROVIDED, however, that:

          (a)  Employee's covenants and obligations set forth in Sections 8, 9,
10, 11, 12, 13 and 14 shall remain in effect and be fully enforceable in
accordance with the provisions thereunder; and

          (b)  in the event that Employee's employment is terminated by the
Company without Cause at any time after January 1, 2003, Employee shall be
entitled to receive (i) the installments of base salary set forth in Section
5(a) not yet paid to such Employee, payable when and as if Employee had
continued to be employed by the Company until the three month anniversary of the
date of such termination, and (ii) the benefits set forth in Section 6(b) for
such period of time.

     18.  MISCELLANEOUS.

          (a)  ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
among the parties with respect to the subject matter hereof and supersede all
other prior agreements and understandings, both written and oral, between the
parties with respect to such subject matter, including the Original Agreement.

          (b)  ASSIGNABILITY, ETC. This Agreement shall be binding upon and
inure to the benefit of the parties hereto and their respective successors and
permitted assigns. This Agreement is not intended to confer upon any Person
other than the parties hereto any rights or remedies hereunder, except as
otherwise expressly provided herein and shall not be assignable by operation of
law or otherwise.

          (c)  AMENDMENTS AND SUPPLEMENTS. This Agreement may not be altered,
changed or amended, except by an instrument in writing signed by the parties
hereto; PROVIDED, HOWEVER, that, except as provided in Section 5(c)(ii), no such
alteration, change or amendment may be binding on the Company unless approved by
the Board.

          (d)  NO WAIVER. The terms and conditions of this Agreement may be
waived only by a written instrument signed by the party waiving compliance. In
the case of the Company, no waiver shall be effective unless approved by the
Board. The failure of any party hereto to enforce at any time any of the
provisions of this Agreement shall in no way be construed to be a waiver of any
such provision, nor in any way to affect the validity of this Agreement or any
part hereof or the right of such party thereafter to enforce each and every such
provision. No waiver of any breach of or non-compliance with this Agreement
shall be held to be a waiver of any other or subsequent breach or
non-compliance.

          (e)  CERTAIN DEFINITIONS. For purposes of this Agreement, the
following terms shall have the meanings set forth below:

          "Cause" means:

               (i)   Employee's dishonesty with respect to the Company;

                                        7
<Page>

               (ii)  Employee's misconduct which materially and adversely
reflects upon the business, affairs, operations, or reputation of the Company or
upon Employee's ability to perform his duties for the Company;

               (iii) Employee's failure (except by reason of Disability) to
perform his duties and responsibilities for the Company, which failure continues
for more than ten days after the Company gives written notice to Employee which
sets forth in reasonable detail the nature of such failure;

               (iv)  Employee's negligent performance of his duties, which
negligent performance continues for more than ten days after the Company gives
written notice to Employee which sets forth in reasonable detail the nature of
such negligence; or

               (v)   Employee's breach of any one or more of the material
provisions of this Agreement, which breach continues for more than ten days
after the Company gives written notice to Employee which sets forth in
reasonable detail the nature of such breach.

          "Disability" means the inability of Employee to substantially perform
his duties to the Company by reason of any medically determinable physical
impairment.

          "Field of Interest" means the field of sequencing, chemical, enzymatic
or biological synthesis, production or modification of linear and branched
sugars and glycoconjugates.

          "Long Term Disability" means a Disability which continues for at least
120 consecutive calendar days or 150 calendar days during any consecutive
twelve-month period, after its commencement, and is determined in good faith to
be total and permanent by the Board following consultation with reputable
medical or health experts selected by the Board.

          "Person" shall mean an individual, a corporation, an association, a
partnership, an estate, a trust and any other entity or organization.

          (f)  CONSTRUCTION OF AGREEMENT. A reference to a Section or Exhibit
shall mean a Section in or Exhibit to this Agreement unless otherwise expressly
stated. The titles and headings herein are for reference purposes only and shall
not in any manner limit the construction of this Agreement which shall be
considered as a whole. The words "include," "includes" and "including" when used
herein shall be deemed in each case to be followed by the words "without
limitation."

          (g)  NOTICE. All notices and other communications hereunder shall be
in writing and shall be deemed given if delivered by hand, sent by facsimile
transmission with confirmation of receipt, sent via a reputable overnight
courier service with confirmation of receipt requested, or mailed by registered
or certified mail (postage prepaid and return receipt requested) to the parties
at the following addresses (or at such other address for a party as shall be
specified by like notice), and shall be deemed given on the date on which
delivered by hand or otherwise on the date of receipt as confirmed:

                                        8
<Page>

     To the Company:

          Mimeon, Inc.
          43 Moulton Street
          Cambridge, MA 02143
          Attention: President
          Fax: 617.491.9701

     To Employee:

          Ganesh Venkataraman
          215 Concord Road
          Bedford, MA 02451

          (h)  GOVERNING LAW. This Agreement shall be governed by, and construed
and enforced in accordance with, the substantive laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of laws.

          (i)  REMEDIES. Employee recognizes that money damages alone would not
adequately compensate the Company in the event of breach by Employee of this
Agreement, and Employee therefore agrees that, in addition to all other remedies
available to the Company at law, in equity or otherwise, the Company shall be
entitled to injunctive relief for the enforcement hereof. All rights and
remedies hereunder are cumulative and are in addition to and not exclusive of
any other rights and remedies available at law, in equity, by agreement or
otherwise.

          (j)  SURVIVAL; VALIDITY. Except as expressly provided herein, the
provisions of this Agreement shall not survive termination of Employee's
employment by the Company for any reason. In the event that any provision of
this Agreement shall be determined to be unenforceable by reason of its
extension for too great a period of time or over too large a geographic area or
over too great a range of activities, it shall be interpreted to extend only
over the maximum period of time, geographic area or range of activities as to
which it may be enforceable. If, after application of the preceding sentence,
any provision of this Agreement shall be determined to be invalid, illegal or
otherwise unenforceable by a court of competent jurisdiction, the validity,
legality and enforceability of the other provisions of this Agreement shall not
be affected thereby. Except as otherwise provided in this Section 17, any
invalid, illegal or unenforceable provision of this Agreement shall be
severable, and after any such severance, all other provisions hereof shall
remain in full force and effect.

          (k)  COUNTERPARTS. This Agreement may be executed in one or more
counterparts, all of which together shall constitute one and the same Agreement.

                                    * * * * *

                                        9
<Page>

     IN WITNESS WHEREOF, the parties have caused this Amended and Restated
Employment Agreement to be executed as an agreement under seal as of the date
first written above.

                                      MIMEON, INC.

                                      By:/s/ Alan L. Crane
                                         ---------------------------------------
                                         Alan L. Crane
                                         President and Chief Executive Officer

                                      /s/ Ganesh Venkataraman
                                      ------------------------------------------
                                      Ganesh Venkataraman

                                       10

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