Document:

EX-10.1 ANNUAL INCENTIVE PLAN

 

EXHIBIT 10.1

BioCryst Pharmaceuticals, Inc.

Annual Incentive Plan

Communication Summary for Participants

Effective January 1, 2007

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BioCryst Pharmaceuticals, Inc. Annual Incentive Plan

Effective January 1, 2007

Plan Summary

Objective

The BioCryst Pharmaceuticals Annual Incentive Plan (AIP) is designed to provide senior leaders with
an incentive to achieve critical Company objectives and to perform on an individual basis. The AIP
offers Executive Directors and above an opportunity to share in the Company’s success on an annual
basis.

Overview

As a participant in the AIP, you are eligible to receive an annual incentive award based on two
performance components:

	•	 	BioCryst’s performance relative to annual business objectives established for the plan
year.
	 
	•	 	Your individual performance during the plan year, defined as the degree to which you
achieve your individual objectives and carry out ongoing responsibilities, and the
competencies (behaviors/skills) you exhibit as you work toward the achievement of results.

Your award opportunity is expressed as an annual incentive range, which is stated as a percentage
of your base salary. Your incentive range includes a minimum, a target, and a maximum. Incentive
targets are established based on competitive practice and vary by organizational level. Based on
BioCryst’s actual performance and your performance, your actual incentive award in any given year
may vary from $0 (0% of base salary) to a maximum incentive opportunity established for your
organizational level.

Awards are typically paid during mid-March in the year following the completion of the plan year.
Participants must be employed by BioCryst on the date of payout to eligible to receive an award.

Annual Incentive Opportunity

At the beginning of each plan year, eligible employees are notified of their participation in the
new plan year and the annual incentive range based on their position’s assigned organizational
level. Annual incentive targets and ranges vary by organizational level and are expressed as a
percentage of base salary. (An individual’s base salary as of the end of the plan year is used for
calculation purposes.) A range includes a minimum (0%), a target, and a maximum.

Performance Components and Measures

Annual incentive awards are based on two performance components: BioCryst’s Performance and
Individual Performance. The following provides further details so that you can understand how the
Plan works.

Company Performance Component

At the beginning of the plan year, BioCryst establishes a set of critical performance objectives
that the Company must strive to achieve during the year. These objectives represent BioCryst’s
goals and reflect the Company’s top priorities for the plan year. The objectives typically vary
from year-to-year and focus on research milestones and outcomes, clinical development milestones,
organizational processes, financial targets, and other short-term objectives and initiatives. The
objectives are reviewed and approved by

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BioCryst’s Board of Directors.

At the completion of the plan year, BioCryst’s performance is assessed against the established
business objectives for the plan year. This assessment is based on the extent to which BioCryst’s
annual objectives are achieved — either meeting objectives, partially meeting objectives,
exceeding objectives, or not meeting objectives. This assessment serves as a basis for the
determining the annual incentive pool available for eligible plan participants.

If BioCryst meets all its objectives, the pool is roughly equal to the sum of the individual
targets for the eligible participants in the Plan. As a simplistic example, if there were ten
participants in the AIP who all have a base salary of $100,000 and a target of 20%, the annual
incentive pool if the Company met all its objectives would be roughly
$200,000 ( $100,000 x .20 x 10 ). This pool may be adjusted upward or downward based on actual Company performance
during the plan year.

Individual Performance Component

As a participant, your annual incentive is determined based on your overall performance during the
plan year: the degree to which you achieve your annual objectives and carry out your ongoing
responsibilities, and the competencies (behaviors/skills) you exhibit in the process of achieving
results. This year-end assessment is captured in your Performance Plan for the year as a part of
BioCryst’s Performance Management Program.

The individual incentive target is only relevant when BioCryst achieves all of its objectives. For
a year in which the Company does achieve all its objectives, an employee who is rated as a “strong
performer” would be eligible to receive an award at or close to target. Under BioCryst’s
Performance Management Program, a “strong performer” is defined as:

	•	 	Achieved all individual objectives
	 
	•	 	Most competencies are strong
	 
	•	 	Fully meets all defined performance expectations of position
	 
	•	 	Consistently carries out ongoing responsibilities as defined by role
	 
	•	 	Strong contributions consistently made during the year
	 
	•	 	Solid performer, someone you can always count on

Incentive Award Calculation

Once the overall annual incentive pool is determined, the individual incentive targets are adjusted
based on actual Company performance for the plan year. Individual incentive awards are determined
based on the adjusted incentive targets and individual performance.

Incentive awards will vary relative to the incentive ranges, with differentiation based on
individual performance. In all cases the approved incentive pool must be maintained. In addition,
the individual maximums (expressed as a percentage of base salary) always represent the maximum
incentive possible.

Annual incentive awards are typically paid by March 15 of the year following the completion of the
plan year and are subject to applicable tax withholding based on the current tax laws at the time
of distribution.

Illustration

To illustrate, assume an individual’s annual incentive range is: 0% (minimum), 20% (target) and 25%
(maximum). If, based on BioCryst’s performance, the annual incentive pool is determined to be 75%
of the target incentive pool, then the individual’s target is
adjusted accordingly to 15% ( 20% x .75 ) for the plan year. In order for the employee to receive an incentive at roughly 15%, he or
she would need to be assessed as a “strong performer” under the Performance Management Program.
The maximum incentive possible remains at 25%.

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Administrative Information

Plan Participation

BioCryst Pharmaceuticals employees whose positions are assigned to organizational levels 1, 2 and 3
(Executive Director and above) are eligible to participate in the BioCryst Annual Incentive Plan.

New eligible employees hired on November 1 through the end of the plan year will wait until the
next plan year to participate. New eligible employees who join BioCryst prior to November 1 are
eligible for a pro rata incentive award based on the time period the employee was employed by
BioCryst during the year. Such prorated calculations are made based on whole months (month is
counted in calculation if new hire date is the 15th or earlier).

Changes in Employment

If you separate from BioCryst during the plan year due to death, retirement, or permanent
disability, you are eligible to receive a pro rata award based on your base salary on the date of
separation during the plan year which you were considered an active employee and the number of
whole months actively worked. If you voluntarily or involuntarily terminate employment with
BioCryst before the annual incentive awards are paid, you will forfeit all incentive award
opportunities, regardless of individual and Company performance during the plan year.

Promotions and Demotions

If an eligible employee is promoted or demoted and the change in position results in a change in
organizational level, BioCryst will calculate the employee’s incentive based on the annual
incentive ranges in the old and new positions. This pro rata calculation rounds to the number of
full months in each position.

Questions and Answers

Question: Will BioCryst’s Company performance objectives change from year-to-year?

Answer: Most likely. Because the Annual Incentive Plan is a short-term plan, it focuses on the
achievement of business and individual objectives for a specific plan year. Although the same
financial measure, performance measure or milestone may be used from year-to-year, performance
objectives and achievements will be established and assessed for the specific plan year.

Question: Will BioCryst establish an annual incentive pool for every plan year?

Answer: The annual incentive pool is determined based on BioCryst’s performance during the year
and the extent to which Company objectives are achieved. If BioCryst does not achieve its
objectives and performance thresholds are not attained, no pool will be established and no annual
incentive awards will be earned. Conversely, if BioCryst exceeds performance expectations, the
pool will be set at a level above the target incentive pool. In all cases, the distribution of any
incentive pool is based on the performance of the individuals participating in the AIP.

BioCryst’s Board of Directors also reserves the right not to establish an incentive pool or to
reduce the pool if the financial health of the Company is in jeopardy, regardless of performance
during a plan year.

Question: Will I have to pay taxes on my annual incentive award?

Answer: After the completion of a plan year, awards are then determined based on the extent to
which BioCryst met its objectives and based on your performance during the year. If you are
eligible for an award, your award will be paid and will be subject to applicable withholding taxes
based on the current tax laws at the time of distribution.

Question: Am I eligible for an annual incentive award if my performance warrants being placed on a
Performance Improvement Plan?

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Answer: No annual incentive is paid for any individual who performs poorly and is assessed as a
“weak performer,” regardless of whether the individual is placed on a Performance Improvement Plan
or not. If
such an employee subsequently improves his or her performance, the employee will become eligible
for an incentive in the following plan year.

Question: If I leave BioCryst before awards are paid, am I entitled to receive a portion of the
Annual Incentive Award?

Answer: If you voluntarily or involuntarily leave the Company before payment of the award, you
will forfeit your entire annual incentive award. If, however, you leave the Company due to other
circumstances, different rules may apply (see above).

Question: What happens if I am on a leave of absence during the plan year?

Answer: Awards are prorated based on the time actively worked and time spent on a paid leave of
absence. Any period of time on an unpaid leave of absence will not be counted and the award will
be prorated accordingly.

A Final Word

This Plan Summary describes the provisions of the BioCryst Pharmaceuticals, Inc. Annual Incentive
Plan. BioCryst Pharmaceuticals has the full right to amend, suspend or terminate the plan at any
time. The Compensation Committee of the Board has the right to interpret, modify or adjust any
Plan provision. Enrollment in this plan is not a guarantee of employment.

For illustration purposes, a hypothetical employee and award have been used in this plan summary.
Actual awards, if any, will be determined by the performance of BioCryst Pharmaceuticals and the
individual participant.

81EX-10.2 EXECUTIVE RELOCATION POLICY

 

EXHIBIT 10.2

BioCryst Pharmaceuticals, Inc.

Executive Relocation Policy

Individuals who are offered employment with BioCryst Pharmaceuticals to fill a position in
organizational level 3 or above and who live greater than 45 miles from a BioCryst location are
eligible for relocation benefits under the Executive Relocation Policy. The following summarizes
the components of the policy.

Closing Cost Reimbursement — Departure Home

BioCryst will reimburse normal closing costs once a closing statement is submitted to the Company.
Normal closing costs related to the sales of your previous home include:

	•	 	Title fees including title examination, title transfer and binder
	 
	•	 	Attorney fees — related to title transfer only
	 
	•	 	Tax service and tax registration fees, if required by state
	 
	•	 	Documentary stamps, if needed
	 
	•	 	Inspections and surveys, only if required by local law

Buyer Value Option (under consideration; subject to cost analysis)

BioCryst will provide you with a home sale option through Cartus called the Buyer Value Option,
which is aimed at simplifying the home sale process for you. Prior to listing your home you will
need to work with Cartus to include an exclusion clause and to register your agent. By utilizing
the Buyer Value Option, you are provided with numerous benefits and services. Realtors Commission
and Closing Costs (normal for the area) will be billed directly to BioCryst by Cartus. Once you
have sold your home, Cartus will contract with you and assume the sale. You will not need to
attend the closing with the buyer. Cartus or its representative attends the closing with the
buyer. Further details will be provided to you on this process. (If this option is used, the
language will change in appropriate sections to reflect coverage of closing costs and reimbursement
to Cartus, not employee.)

Realtor Fees — Departure Home

BioCryst will reimburse normal closing costs including realtor commissions on the sale of your
former residence. Commissions will not exceed what is local custom for the area, up to a maximum
of 6%.

Closing Cost Reimbursement — Purchasing a Home in New Location

Normal closing costs related to the purchase of a new home include the following items, subject to
a maximum of 2% of the purchase price:

	•	 	Appraisal and appraisal inspection
	 
	•	 	Credit report
	 
	•	 	Tax service fee
	 
	•	 	Document preparation
	 
	•	 	Settlement or closing fee
	 
	•	 	Title fees including title insurance, binder, title coordination, abstract or title search
	 
	•	 	Escrow documentation fee
	 
	•	 	Notary and attorney, if needed
	 
	•	 	Deed and mortgage transfer fees
	 
	•	 	City, county and/or state stamps
	 
	•	 	Endorsements
	 
	•	 	Inspections, only if required by local law (fee should not exceed normal rate for area)
	 
	•	 	Power of Attorney document preparation and record
	 
	•	 	Underwriting fee

Non-reimbursable purchase closing costs include:

	•	 	Prepaid property taxes, insurance or interest

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	•	 	Construction loan procurement expense and interest
	 
	•	 	Mortgage loan credit insurance
	 
	•	 	Discount/buy down points or fees
	 
	•	 	Home warranty insurance program
	 
	•	 	Private mortgage insurance
	 
	•	 	Expenses normally charged to the seller.

House Hunting Trip

One house hunting trip is available to locate a personal residence before relocating. This trip is
provided for you and your spouse for up to seven days. This includes coach airfare, car rental,
meals and lodging. Trip should be made over a weekend for best airfare available.

Return Trips

BioCryst will the cover your coach airfare associated with making return trips to your current city
of residence every other weekend for a three-month period from your hire date.

Household Goods

Arrangements with a moving company of BioCryst’s choice will be made to pack, load, unload and
unpack your household goods. Storage of household goods is available for up to 90 days or until a
personal residence is located, whichever is less. You will be invoiced and responsible for payment
for storage costs beyond 90 days.

Final Move — Includes Meals, Lodging, Mileage or Airfare

Coach air travel to your new location will be provided for you and your spouse. If you drive,
reasonable and actual traveling expenses such as lodging, meals and mileage using the most direct
route will be reimbursed at the prevailing IRS rate. Meals shall not exceed $50 per day per
person.

Temporary Housing

Temporary housing will be provided to you for up to 90 days or until a personal residence is
located, whichever is less. BioCryst will work with you to locate a suitable one-bedroom apartment
or temporary residence.

Rental Car While in Temporary Housing

Upon arrival at destination, a rental car will be provided for up to 7 days. If you drive to your
new location, this benefit will not be provided.

Relocation Allowance

A one-time payment equal to one month’s base salary, subject to a maximum of $5,000, is provided to
you to apply toward miscellaneous incidental incurred during your relocation that you are not
otherwise reimbursed. Examples of such incidental items include:

	•	 	Utility hook-up/installation
	 
	•	 	Driver’s license and automobile registrations
	 
	•	 	Retuning of piano
	 
	•	 	Pet boarding fees
	 
	•	 	Cable hook-up
	 
	•	 	Trash removal

Repayment of Relocation

If you voluntarily terminate your employment from BioCryst for any reason before you have completed
twelve months of active employment from your hire date, you will be responsible for reimbursing the
Company for any relocation expenses paid to you or incurred by the Company on your behalf, on a
pro-rated monthly basis.

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