Document:

Exhibit 4.47

 

 

CNOOC
Finance Corporation Limited

 

 

 

and

 

 

 

CNOOC
Limited

 

 

 

	 

                                                                                         Framework
Agreement  

        in
respect of  

        the
        Financial Services

         

 

 

 

 

 

(Summary
Translation)

 

 

     

     

    

Framework Agreement in respect of the Financial Services

 

This
Framework Agreement in respect of the Financial Services (the “Agreement”) was entered into on December 1,
2016 by the following parties in Beijing, the People’s Republic of China (“PRC”, excluding for the purpose
of this Agreement, the Hong Kong Special Administrative Region, the Macau Special Administrative Region and Taiwan):

 

Party
A: CNOOC Finance Corporation Limited, a company incorporated and existing under the laws of the PRC with limited liability
having its registered address at No. 25 Chaoyangmenbei Dajie, Dongcheng District, Beijing, PRC.

 

Party
B: CNOOC Limited, a company incorporated and existing under the laws of the Hong Kong Special Administrative Region
(“Hong Kong”) with limited liability having its registered address at 65/F, Bank of China Tower, 1 Garden Road,
Hong Kong.

 

(Collectively
the “Parties” and individually the “Party”.)

 

WHEREAS:

 

		1.	Party
                                         A is a non-bank financial institution affiliated to China National Offshore Oil Corporation
                                         (“CNOOC”), which is approved by China Banking Regulatory Commission
                                         (the “CBRC”) and registered at State Administration for Industry and
                                         Commerce, and is qualified for providing financial services to CNOOC group members;

 

		2.	Party
                                         B is a subsidiary (as defined under the Rules Governing the Listing of Securities on
                                         The Stock Exchange of Hong Kong Limited (the “Listing Rules”)) of
                                         CNOOC and is listed on The Stock Exchange of Hong Kong Limited (the “Stock Exchange”),
                                         the New York Stock Exchange and the Toronto Stock Exchange;

 

		3.	Party
                                         B, out of ordinary business needs, expects to receive financial services from Party A
                                         with fair and reasonable market prices and on normal commercial terms or terms no less
                                         favorable than terms than those provided by independent third parties. On this basis,
                                         the Parties hereby agree to enter into this Agreement and to provide / accept the financial
                                         services as agreed;

 

    2 

     

    

 

		4.	CNOOC
                                         is an indirect controlling shareholder of Party B, holding 64.44% interests in Party
                                         B’s issued shares. Party A is a subsidiary of CNOOC and a connected person of Party
                                         B in accordance with the Listing Rules. The transactions between Party A and Party B
                                         in this Agreement constitute continuing connected transactions under the Listing Rules;
                                         and

 

		5.	Party
                                         B hereby agrees to, and ensures to procure its subsidiaries to, accept the financial
                                         services as stipulated in this Agreement in accordance with the terms and spirits of
                                         this Agreement.

 

NOW,
THEREFORE, with respect of the supply and acceptance of financial services, in accordance with the Contract Law of the People's
Republic of China, the Administrative Measures on Finance Companies of Enterprise Groups promulgated by CBRC and other existing
PRC laws and regulations, the Parties hereby agree as follows:

 

Article
1          Financial Services

 

1.1             
Party A hereby agrees to provide financial services to Party B and its subsidiaries pursuant to this Agreement and Party
B and its subsidiaries also hereby agree to accept the financial services as set forth below provided by Party A from time to
time pursuant to this Agreement, provided that Party B and its subsidiaries are members of CNOOC group in accordance with the
Administrative Measures on Finance Companies of Enterprise Groups and the financial services provided by Party A are within its
business scope approved by CBRC and confirmed by State Administration for Industry and Commerce:

 

		(1)	settlement
                                         services;

 

		(2)	depositary
                                         services;

 

    3 

     

    

 

		(3)	discounting
                                         services;

 

		(4)	loan
                                         services; and

 

		(5)	entrustment
                                         loans services.

 

1.2             
Party A hereby agrees to, from time to time, provide relevant information with respect to financial services set forth
above to Party B and its subsidiaries as required by Party B, such as deposit / loan status and maximum daily outstanding balance
of deposits of Party B and its subsidiaries and deposit interest rates of commercial banks.

 

Article
2          Transaction Principles

 

2.1             
The Parties hereby agree that Party A shall provide Party B and its subsidiaries financial services under Section 1.1 of
this Agreement in accordance with the following principles:

 

		(1)	Provision
                                         of settlement services: Party A will provide settlement services to Party B and its subsidiaries
                                         on a free-of-charge basis;

 

		(2)	Provision
                                         of depositary services: when Party A provides depositary services to Party B and its
                                         subsidiaries, the interest rates must be agreed by both parties and determined in accordance
                                         with the relevant unified standard deposit interest rates as promulgated by the People’s
                                         Bank of China (the “PBOC”) from time to time and may be subject to
                                         upward adjustment of up to 40% of such PBOC standard deposit interest rates subject to
                                         the requirements of the PRC laws and regulations and with reference to the deposit interest
                                         rates offered by commercial banks for deposit of the same nature and maturity;

 

		(3)	Provision
                                         of discounting services: when Party A provides discounting services regarding commercial
                                         drafts to Party B and its subsidiaries, the interest rates are the relevant unified standard
                                         interest rates for discounting services as promulgated by the PBOC from time to time,
                                         and such interest rates may be adjusted downward in separate financial service agreements
                                         subject to the requirements of the PRC laws and regulations;

 

    4 

     

    

 

		(4)	Provision
                                         of loan services: when Party A provides loan services to Party B and its subsidiaries,
                                         the interest rates are the relevant unified standard interest rates for loans as promulgated
                                         by the PBOC from time to time; such interest rates may be adjusted downward subject to
                                         the requirements of the PRC laws and regulations. Further, the parties agreed that the
                                         loans provided by Party A to Party B and its subsidiaries are not required to be secured
                                         by assets of Party B and its subsidiaries; and

 

		(5)	Provision
                                         of entrustment loans services: when Party A provides entrustment loans services to Party
                                         B and its subsidiaries, the annual service fees are calculated based on the principal
                                         balances of the loans. The aggregate amount of the annual service fee plus the interest
                                         on the relevant loan shall not exceed the interest payable by Party B and its subsidiaries
                                         on a loan of same maturity charged by commercial banks.

 

2.2             
Party B and its subsidiaries shall have the right, in their sole discretion with respect to their own benefits, to decide
whether to obtain services set forth above from Party A.

 

2.3             
In the event of any misappropriation or misuse by Party A in respect of the funds deposited with it by the Party B or its
subsidiaries which results in the inability of Party B or its subsidiaries to recover such funds, Party B or its subsidiaries
shall offset amounts due to Party B or its subsidiaries from Party A against amounts outstanding from Party B or its subsidiaries
to Party A. Party A has no such right of set off.

 

Article
3          Mode of Operations

 

3.1             
The Parties and Party B shall ensure and procure its subsidiaries to, if necessary, enter into separate financial service
agreements on normal commercial terms and in compliance with the terms of this Agreement, and cause separate financial service
agreements to be in accordance with the principles set out in this Agreement and subject to the requirements of the PRC laws and
regulations (including but not limited to requirements of the Listing Rules).

 

    5 

     

    

 

3.2             
The term of such separate financial service agreements executed pursuant to this Agreement shall not exceed three years.
Where the term of such agreement does not exceed three years but the expiry date thereof is later than December 31, 2019, then
the following provision shall be incorporated into these agreements: “In the event that CNOOC Limited fails to comply with
the applicable requirements under the Rules Governing the Listing of Securities on The Stock Exchange of Hong Kong Limited in
relation to connected transactions, unless CNOOC Limited can satisfy the conditions of the relevant exemptions, this contract
shall be terminated on December 31, 2019”.

 

3.3             
The financial service agreements which were executed between Party A and Party B or its subsidiaries prior to the effective
date of this Agreement and has not expired, shall be valid after this Agreement becomes effective and shall be deemed as separate
financial service agreements signed in compliance with the principles and terms of this Agreement. Corresponding amendments, however,
shall be made in accordance with the principles and terms of this Agreement if the principles and terms of such agreements are
inconsistent with those set out in this Agreement.

 

Article
4          Term and Termination

 

4.1             
This Agreement shall become effective on January 1, 2017 upon execution by the authorised representatives of the Parties
and shall remain in effect for a term of three years until 31 December 2019. This Agreement can be extended to another three years
when the abovementioned term expires, provided that the Parties consent in writing and such extension complies with the provisions
related to the requirements for connected transactions under the Listing Rules.

 

    6 

     

    

 

4.2             
Any of the Parties in this Agreement can terminate this Agreement or the supply / acceptance of any specific financial
services in this Agreement, provided that it shall notify the counterpart in writing three months in advance and shall clarify
the termination of this Agreement or the specific financial services which will be terminated and the date of termination. The
termination of the supply / acceptance of specific financial services shall not affect other rights and obligations of the Parties
in this Agreement, nor other rights and obligations in the separate financial service agreements executed pursuant to this Agreement
or in relevant confirmation documents owned by any of the Parties in such agreements or relevant confirmation documents.

 

4.3             
If any comments or requests should be made by the Stock Exchange or for the purpose of complying with any requirements
of the Listing Rules, the Parties hereby agree to make corresponding modification to the terms of this Agreement in accordance
with such comments or requests of the Stock Exchange or requirements of the Listing Rules.

 

4.4             
If any Party breaches any terms of this Agreement (the “Defaulting Party”), the other Party (the “Non-Defaulting
Party”) may notify the Defaulting Party in writing of such breach and request the Defaulting Party to make relevant
remedies within a designated reasonable period; if the Defaulting Party fails to remedy such defaulting action within such reasonable
period, the Non-Defaulting Party may immediately terminate this Agreement or the supply / acceptance of specific financial services.
The Non-Defaulting Party reserves the right to recourse and claim compensation and any other claims available under the applicable
laws.

 

4.5             
If one Party is bankrupt, insolvent, in the legal procedure of liquidation or has ceased operation, the other Party may
notify that Party in writing to terminate this Agreement.

 

4.6             
If all supply / acceptance of financial services as described in this Agreement have been terminated, this Agreement shall
be terminated therefore.

 

    7 

     

    

 

4.7             
The termination of this Agreement shall not affect the existing rights or obligations of any of the Parties accrued pursuant
to this Agreement, including the obligation of making due and payable payment and the obligation of making default and damages
payment resulted from breach of this Agreement.

 

Article
5          Representations and Warranties

 

5.1             
Party A represents and warrants that:

 

		(1)	Party
                                         A is a non-bank financial institution incorporated and duly existing under the laws of
                                         the PRC as an independent legal entity;

 

		(2)	The
                                         financial services provided by Party A to Party B and its subsidiaries pursuant to this
                                         Agreement do not exceed Party A’s approved and confirmed business scope;

 

		(3)	Party
                                         A has obtained all the government approvals (if necessary) and authorisations as required
                                         for the execution and performance of this Agreement; this Agreement is executed by the
                                         authorised representative of Party A, and this Agreement shall be binding on Party A
                                         once it has been executed;

 

		(4)	The
                                         execution and performance of this Agreement by Party A will not violate any other agreements
                                         entered into by Party A or its articles of association, nor will conflict as a matter
                                         of law with other agreements entered into by Party A or its articles of association;
                                         and

 

		(5)	Party
                                         A hereby agrees to allow the auditor of Party B to audit the transaction records of Party
                                         B and its subsidiaries in connection with this Agreement while Party B is listed on the
                                         Stock Exchange, in order to facilitate Party B to fulfil its disclosure obligations under
                                         the Listing Rules.

 

5.2             
Party B represents and warrants that:

 

    8 

     

    

 

		(1)	Party
                                         B is a company incorporated and duly existing under the laws of the Hong Kong with limited
                                         liability as an independent legal entity;

 

		(2)	Party
                                         B has obtained all government approvals (if necessary) and internal authorisations as
                                         required for the execution and performance of this Agreement ; this Agreement is executed
                                         by the authorised representative of Party B, and this Agreement shall be binding on Party
                                         B once it has been executed; and

 

		(3)	The
                                         execution and performance of this Agreement will not violate any other agreements entered
                                         into by Party B or its articles of association nor conflict as a matter of law with other
                                         agreements entered into by Party B or its articles of association.

 

Article
6          Performance of this Agreement

 

6.1             
If any of the transactions under this Agreement and the modification, amendment, revocation or re-signing of this Agreement
constitutes a connected transaction pursuant to the Listing Rules, these transactions shall only be implemented after complying
with the relevant requirements related to the connected transactions under the Listing Rules (if applicable); therefore, compliance
with relevant requirements related to the connected transaction under the Listing Rules (if applicable) shall be a condition precedent
to this Agreement and such transactions.

 

6.2             
If a conditional waiver is granted by the Stock Exchange, this Agreement shall be implemented according to the conditions
so stipulated.

 

6.3             
If a waiver from the Stock Exchange in respect of a certain connected transaction is lapsed, withdrawn or revoked, and
the transaction fails to comply with the requirements of the Listing Rules related to connected transactions, then the performance
under this Agreement regarding that transaction shall be terminated.

 

6.4             
If the amount of connected transaction under this Agreement may exceed the relevant cap determined after Party B has fulfilled
its reporting and announcement obligations, Party B shall comply with the requirements of the Listing Rules as soon as possible,
including to hold a general meeting to pursue independent shareholders to approve a new cap (if necessary). Before complying with
the relevant requirements under the Listing Rules, the Parties hereby agree to use its best efforts, respectively, to procure
relevant transactions to be limited within the original annual caps determined after Party B has fulfilled its reporting and announcement
obligations.

 

    9 

     

    

 

Article
7          Liabilities for Breach of Contract

 

7.1             
The Parties shall perform its obligations respectively pursuant to this Agreement; the Party who does not perform in
conformity with this Agreement causes the other Party to suffer losses as a result thereof shall undertake the liabilities for
breach of contract, including being liable to pay compensatory damages, in accordance with the PRC laws.

 

Article
8          Force Majeure

 

8.1              If
an event of Force Majeure occurs to any Party of this Agreement (Force Majeure events shall mean any event which is beyond
the reasonable control of the affected Party, unforeseen or unavoidable and insurmountable even if foreseeable, and
which arises after the date of this Agreement and which makes the total or partial performance of this Agreement by that
Party become objectively impossible or impracticable (including but not limited to the failure to perform even when a
reasonable amount of money has been spent). Such events shall include but are not limited to flood, fire, drought, typhoons,
earthquakes and other natural disasters, traffic accidents, strikes, unrests, riots and war (whether declared or not), and
acts or omissions of government departments) and the impact of such event of Force Majeure has resulted in the failure to
perform all or part of its obligations under this Agreement, the performance of such obligations shall be suspended during
the period of an event of Force Majeure.

 

8.2             
The Party claiming Force Majeure shall make its best efforts to inform the other Party in writing and shall furnish within
fifteen days after the Force Majeure has taken place, proper proof of the occurrence and duration of such Force Majeure by hand
or registered post. The Party claiming that a Force Majeure event has made the performance of this Agreement objectively impossible
or impracticable shall have the liability to use all reasonable endeavours to eliminate or mitigate the impact of such Force Majeure
event.

 

    10 

     

    

 

8.3             
In the event of Force Majeure, the Parties shall promptly decide how to implement this Agreement through friendly negotiations.
After the termination or elimination of the Force Majeure events or its consequences, the Parties shall promptly resume the performance
of their respective obligations under this Agreement. If the Parties, in consideration of the actual impact, enter into a supplementary
agreement with respect to the obligations under this Agreement affected by Force Majeure, the obligations shall be performed in
accordance with the supplementary agreement.

 

Article
9          Announcement

 

9.1             
Save for announcement made pursuant to the laws of the PRC or the requirements of the CBRC, the China Securities Regulatory
Commission, the Stock Exchange, the Securities and Futures Commission of Hong Kong, the New York Stock Exchange, the US Securities
and Exchange Commission, the Toronto Stock Exchange or any other governmental or regulatory authorities, neither party shall make
any announcement regarding this Agreement without the prior written consent of the other party.

 

Article
10          Governing Law and Dispute Resolution

 

10.1         
This Agreement shall be governed and construed in accordance with the laws of the PRC.

 

10.2         
Any dispute arising out of or relating to this Agreement shall be settled by negotiation between the Parties. If negotiation
cannot settle the dispute within 30 days, either Party may submit such dispute to China International Economic and Trade Arbitration
Commission located in Beijing for arbitration in accordance with the arbitration rules of such arbitration commission in effect
at the time of application of such arbitration. Any arbitral award shall be final and binding upon both Parties.

 

    11 

     

    

 

10.3         
Except for the clauses being disputed, the Parties shall continue to perform other clauses in this Agreement during the
course of the negotiation and arbitration.

 

Article
11          Miscellaneous

 

11.1         
The headings of sections in this Agreement are for convenience of reference only and shall not have legal validity
or affect the interpretation of this Agreement.

 

11.2         
Save as otherwise provided in this Agreement, neither Party shall transfer in whole or in part its rights or obligations
under this Agreement without the prior written consent of the other Party.

 

11.3         
This Agreement shall supersede all prior verbal or written agreements, contracts, understanding and communication between
Parties with respect to such matters.

 

11.4         
If any clause in this Agreement becomes illegal, invalid or unenforceable, it shall not affect the validity and enforceability
of the other clauses of this Agreement.

 

11.5         
The Parties agree to be liable for all fees and expenses arising from the execution of this Agreement pursuant to the relevant
PRC laws. If there is no relevant law in relation to such payments, the fees and expenses shall be borne equally by the Parties.

 

11.6         
This Agreement shall only be amended in writing, signed and sealed by the authorised representatives from the Parties and
shall be subject to approvals given through appropriate corporate actions from the Parties. If such amendment constitutes a substantive
or material amendment to this Agreement, then such amendment shall only become valid upon compliance with the relevant requirements
of the Listing Rules.

 

11.7         
Unless otherwise provided, no failure or delay on the part of either Party to this Agreement in exercising any right, power
or privilege hereunder shall operate as a waiver of any right, power or privilege of the other party hereto. The single or partial
exercise of any right, power or privilege hereunder by any Party shall not preclude any other exercise of any other right, power
or privilege hereunder in the future.

 

    12 

     

    

 

11.8         
All notices or other correspondences made by a Party pursuant to this Agreement must be in writing and in Chinese, and
must be left at the designated address of the other Party by hand or by registered post, or sent by facsimile to the designated
facsimile number of the other Party. A notice is deemed to have validly made on a date subject to the following provisions: in
the case of a notice delivered by hand, the date of receipt by a designated person of the other Party; in the case of a notice
by registered post, on the seventh day after the posting (evidenced by the postage stamp) (if the last day is a Saturday, Sunday
or official holiday, then the next following working day); in the case of a notice by facsimile, upon the facsimile being sent.

 

11.9         
This Agreement shall be in Chinese and executed in two originals, each of which shall be held by the parties respectively
and shall be of equal force and effect.

 

IN
WITNESS whereof which the parties have executed this Agreement on the date and place first above written.

 

[Below
intentionally left blank and signature pages follow]

 

 

    13 

     

    

 

CNOOC Finance
Corporation Limited

 

 

	 	 

Authorised
Representative

		Title:	

 

 

 

 

 

CNOOC
Limited

 

 

	 	 

Authorised
Representative

		Title:	

 

 

 

 

 

[Signature
pages to Framework Agreement in respect of the Financial Services

 

 

    14EX-4.6

 Exhibit 4.6 

[***] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED. 

Cost Splitting Agreement 
 This Cost Split
Agreement (the “Agreement”) made on February 6th, 2017 (the “Effective Date”) by and between Kissei Pharmaceutical Co., Ltd., having its registered office at 19-48, Yoshino,
Matsumoto-City, Nagano-Prefecture, Japan (“Kissei”) and ObsEva SA, having its principal place of business at Chemin des Aulx, 12, 1228 Plan-les-Ouates, Switzerland (“ObsEva”).

 WHEREAS, Kissei and ObsEva have entered into the Exclusive License Agreement as of November 19, 2015 (the “License Agreement”);

 WHEREAS, Kissei and ObsEva have been developing the Compound and the Product in their respective Territory; and 

WHEREAS, pursuant to Section 6.02 of the License Agreement and the agreement, as a minutes, by and between the Parties hereto at the Joint Development
Committee held on May 18 and 19, 2016, Kissei and ObsEva discussed and determined the procedures of cost splitting for the non-clinical studies and the clinical pharmacology studies of the Compound and
the Product which each Party conducted and will conduct under the terms and conditions set forth herein. 
 NOW, THEREFORE, in consideration of the
covenants and obligations expressed herein, and intending to be legally bound, the Parties hereto agree as follows: 
  

	1.	Definitions. Capitalized terms not defined herein shall have the meaning as set forth in the License Agreement. 

  

	2.	Target Studies. The studies to split the cost between the Parties (the “Target Studies”) shall be listed in the Exhibit A attached hereto. In case that the Parties agree to add to or remove from
the Target Studies regarding particular studies, the Parties shall amend the Exhibit A in accordance with Section 29 of the License Agreement. The Party conducting such Target Studies (the “Conductor”) shall submit to the other
Party (the “Recipient”) an Opt-in sheet sign off document (the “Opt-In Sheet”); a template
Opt-In Sheet is provided at Exhibit B. 

 Considering the fact that the Target Studies
highlighted in yellow in Exhibit A already started at the time of execution of this Agreement (the “Started Target Studies”) and that both Parties agreed to share the cost of the Started Target Studies at the JDC meeting held on
May 18 and 19, 2016 and on December 13 and 14, 2016, the Parties agree not to have an Opt-In Sheet for the Started Target Studies. Except for the procedures related to the Opt-In Sheet, all terms of this Agreement shall apply to the Started Target Studies. 

	3.	Procedures of Cost Splitting. The Parties shall in principle equally bear the external cost for the Target Studies. The Conductor shall submit the study Opt-In Sheet
including in particular a cost estimate to the Recipient after the Conductor has obtained the cost estimates on the Target Studies. The Recipient may give the Conductor comments, if any, for such cost estimate and the Conductor shall take into
account such comments from the Recipient as far as they are scientifically and objectively appropriate and reasonable. Once the Opt-In Sheet is signed off by both Parties, the Recipient agrees to share the
cost of the relevant Target Study pursuant to such Opt-In Sheet. The Conductor shall submit to the Recipient copies of all contracts entered into with third parties pertaining to the Target Studies, if any, as
soon as they are executed. In this case, Section 32 of the License Agreement shall not apply, but the Conductor shall provide a reasonable summary of the main terms related to the contracts it submitted to the Recipient (including but not
limited to the study design or protocol, compound synthesis, timelines, costs) in English where such contracts are drafted in another language. 

Within 5 business days after the end of each calendar quarter, the Conductor shall provide to the Recipient an invoice for an
half of aggregate costs of such Target Studies occurred in the calendar quarter accompanied by the documents to confirm such costs. Notwithstanding the foregoing in this Section 3, the Parties may determine the due date of the payment by prior
mutual consent in writing. The Recipient shall pay such costs within thirty (30) days from receiving of such invoice by wire transfer. The invoice shall be in US Dollars volume and in case that the costs incurred on the other currency basis,
the Conductor shall convert such currency to US dollars using the TTS exchange rate of the date that the cost incurred, which is quoted by the Mizuho bank. (http://www.mizuhobank.co.jp/rate/market/quote/backnumber_pdf.html) 

For the sake of clarity, each Party may have the right to choose – at any time for the Started Target Studies and after Opt-In Sheet is signed off by both Parties for the other Target Studies – subject to both Parties’ written agreement, not to bear the cost of a Target Study in case that the Party demonstrates
(i) that the design of such Target Study does not meet the regulatory requirements in EU and the US in case of ObsEva or Japan in case of Kissei (a “Variance”), and (ii) that such Party is not at fault; for the sake of
clarity, a Party is at fault in particular (i) if it did not identify a Variance at the moment of signing off the Opt-In Sheet, or (ii) if a Variance is identified, at any time, by such Party and it
does not liaise with the relevant regulatory authority to obtain approval for the study design, or (iii) if, at any time, such Party identifies a Variance or a regulatory authority does not approve the study design and such Party does not
immediately inform the other Party thereof (through the JDC). In this case, the cost already paid to the other Party for such Target Study shall be refunded to the Party choosing not to bear the cost, to the extent the results of such Target Study
are not at all useful to such Party. 

 [***] = CONFIDENTIAL TREATMENT REQUESTED 

In case the Conductor anticipates that any material element of a Target Study included in the relevant Opt-In Sheet (e.g. the total budget amount) shall be reviewed, reconsidered or changed, the Conductor shall forthwith raise the issue to the JDC. 

Each Party has the option to acquire from the other Party the report and data of a study conducted by the other Party (in which
it has not initially accepted to participate) during the course of conducting such study or after the completion of such study. The Party could review the study’s report and data as far as the other Party obtained at the moment to decide to be
the Recipient. In this case Section 32 of the License Agreement shall not apply. Once the Party is to be the Recipient such Party generally shall pay to the other Party half of the external cost of such study + a [***]% markup prior to being
delivered the study’s report and data. 
  

	4.	Resolution. Any question or dispute arising out of, or in connection with, this Agreement shall be settled pursuant to Section 20 of the License Agreement. 

IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be executed in duplicate counterparts by their duly authorized representatives, each
fully executed copy hereof to be deemed as original, as of the Effective Date. 
  

			
	Kissei Pharmaceutical Co., Ltd.
		
	By:	 	   /s/ Katsuyoshi Akiyama

		 	    Katsuyoshi Akiyama
		 	    Senior Director
		 	    Business Development & Licensing
	
	ObsEva SA
		
	By:	 	   /s/ Ernest Loumaye

		 	    Ernest Loumaye, Chief Executive Officer
		
	By:	 	   /s/ Jean-Pierre Gotteland

		 	    Jean-Pierre Gotteland, Chief Scientific Officer

 [***] = CONFIDENTIAL TREATMENT REQUESTED 

Exhibit A    The Target Studies 
  

			
	 Study
	  	Conducted by:
	[***]	  	
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	[***]	  	
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	[***]	  	
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]
	 [***]
	  	[***]

 The cost of the Target Studies shall include the costs which are charged from third parties with regard to such Target
Studies, including, but not limited to: 
  

	•	 	[***] 

 ### 

 Exhibit B    Template Opt-In Sheet 

ObsEva SA – Kissei Pharmaceuticals 

Collaborative Development Project Proposal 

Concept Sheet Sign Off 
  

					
	Project Leader	  	Kissei    ☐	  	ObsEva    ☐
	Project title	  		  	
	Project Reference Number	  		  	
	 Brief description (1)

 
	  		  	

					
	Starting Date	  	(Date of project spending initiation)	  	
	Completion Date	  	(Date of final CSR Sign-Off)	  	
	Budget summary (1)	  	(Insert the total budget amount)	  	
	 Timelines and Milestones Summary(1)

e.g. CA review and expected approval as well as FPI/LPO/DB lock/draft CSR/etc.
	  	

  

	(1)	See attached details 

  

					
	 Project Leader Signature (Alliance Manager)
  

                          
      
	  	Date: (__/__/____)
		
	Partner Decision	  	Final due date: (__/__/____)
	Participate        ☐	  	Decline        ☐	  	Effective Date: (__/__/____)
	Signature (Alliance Manager)	  	
	  

                          
      
	  	
		
	 Project Leader Acknowledgement

(Alliance Manager)
	  	Date:
		
	                                	  	                                    

 Note:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}]]