Document:

AMENDED AND RESTATED
                          REGISTRATION RIGHTS AGREEMENT

      THIS AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT (this
"Agreement"), dated as of October 14, 2002, is by and among BioForce
Nanosciences, Inc., a Delaware corporation (the "Company"), FCPR SGAM
BIOTECHNOLOGY FUND, an investment fund organized under the laws of France (the
"Investor"), duly represented by its management company Societe Generale Asset
Management, and such persons or entities that become parties to this Agreement
as permitted pursuant to Section 7A hereto.

      WHEREAS, the Company and the Investor entered into that certain
Registration Rights Agreement, dated as of January 18, 2002 (the "Original
Agreement");

      WHEREAS, the Company and the Investor have entered into that certain Stock
Purchase Agreement, dated as of October 14, 2002 (the "Purchase Agreement"),
pursuant to which, among other things, the Investor has agreed to purchase an
aggregate of 2,333,333 shares of Common Stock, $0.01 par value, of the Company
(the "Common Stock"), subject to certain anti-dilution adjustment provisions
contained therein;

      WHEREAS, the parties desire to amend and restate the Original Agreement by
granting the Investor certain registration rights associated with the shares of
Common Stock purchased by the Investor under the Purchase Agreement;

      WHEREAS, the execution and delivery of this Agreement by the Company is a
condition precedent to the obligations of the Investor under the Purchase
Agreement; and

      WHEREAS, the Investor enters into this Agreement with the intent, for
purposes of this Agreement, to be considered as one class and to be bound by the
same terms and conditions as the future purchasers of up to an additional
2,000,000 shares of Common Stock sold after the date of this Agreement, or
issuable upon conversion of convertible securities of the Company sold after the
date of this Agreement, subject to the consent of the Company and the agreement
of such purchasers to be similarly bound.

      NOW, THEREFORE, in consideration of the premises, the mutual agreements
herein set forth below and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows:

1. Registration on Request.

      (a) Request. Subject to the limitations set forth in Section 1(b), a
Holder or Holders (as defined in Section 8) may require on up to three
occasions, upon written notice to the Company, the Company to effect the
registration under the Securities Act of 1933, as amended (the "Securities
Act"), of all or part of the Registrable Shares (as defined in Section 8) held
by such requesting Holder or Holders (each, an "Initiating Holder"). The Company
promptly shall give notice of such requested registration to all other Holders
of Registrable Shares who are entitled pursuant to Section 2 to join in such
registration and, thereupon, subject to Section 2(b), the Company shall use its
best efforts to effect, on the earliest possible date, the registration under
the Securities Act for public sale, of the Registrable Shares that the Company
has been requested to register by such Initiating Holder or Holders and the
other Registrable Shares that the Company has been requested to register by the
Holders thereof by written notice given to the Company within 20 days after the
giving of such notice by the Company.

<PAGE>

      (b) Limitations. The Company shall not be required to effect a
registration pursuant to Section 1(a):

            (i) prior to the earlier of the following events (A) the
      consummation of the Initial Public Offering and (B) the third anniversary
      of this Agreement;

            (ii) within 120 days after the effective date of a registration
      statement (a "Registration Statement") filed by the Company with the
      Securities and Exchange Commission (the "Commission") for a public
      offering and sale of equity securities of the Company (other than a
      registration of securities pursuant to a Registration Statement on Form
      S-8 or Form S-4 or any similar form or any successor form to any thereof
      (a "Special Registration Statement")), provided that the Company shall use
      its best efforts to achieve effectiveness of a registration requested
      hereunder promptly following such 120 day period if such request is made
      during such 120 day period; provided, further, such 120 day period shall
      be increased to no more than 180 days if requested in writing by the
      managing underwriter of a firm commitment underwritten offering.

            (iii) on more than three occasions it being understood and agreed
      that a registration effected under either Section 2 or 2A shall not be
      counted as a registration under this Section 1;

            (iv) if fewer than seventy-five percent of the issued and
      outstanding Registrable Shares of Common Stock or Registrable Shares of
      Common Stock having an aggregate offering price of less than $3,000,000
      are included in the demand for registration;

            (v) if the Company shall furnish to the Initiating Holders a
      certificate signed by the Chief Executive Officer of the Company stating
      that, in the good faith judgment of the Board of Directors of the Company,
      it would be seriously detrimental to the Company or its stockholders for a
      registration statement to be filed in the near future, in which case the
      Company's obligations to use best efforts to register Registrable Shares
      pursuant to Section 1(a) shall be deferred for a period not to exceed 90
      days from the receipt of the written notice to the Company from the
      Initiating Holders provided, however, that the Company may not exercise
      the right described in this Section 1(b)(v) more than once in any one-year
      period; provided, further, that the Company may not exercise the right
      described in this Section 1(b)(v) within 90 days of the expiry of any
      period described in Section 1(b)(ii);

            (vi) covering any security other than Registrable Shares;

            (vii) registering a "best efforts" underwriting; and

                                      -2-
<PAGE>

            (viii) with respect to the Initial Public Offering unless the
      estimated gross proceeds of such offering exceeds $20,000,000 and the
      Common Stock to be issued in such offering is to be quoted on the National
      Market System tier of the Nasdaq Stock Market or listed on the New York
      Stock Exchange or such other exchange as agreed to by the Company.

      (c) With respect to any registration pursuant to this Section 1, if the
managing underwriter advises the Company that the inclusion of all Registrable
Shares proposed to be included in such registration would materially and
adversely affect the successful marketing (including pricing) of the Registrable
Shares proposed to be included in such registration, then the number of
Registrable Shares proposed to be included in such registration shall be
reduced, such reduction shall be applied pro rata among the Holders thereof
based upon the number of Registrable Shares requested to be registered by each
such Holder.

      (d) If the proposed method of distribution is an underwritten offering,
the managing underwriter shall be an underwriter of national prominence mutually
agreed upon by the Initiating Holders holding a majority of the Registrable
Securities to be sold in such offering and the Company. Whenever a requested
registration is for an underwritten offering, only securities that are to be
included in the underwriting may be included in the registration unless the
managing underwriter consents otherwise.

      2. Incidental Registration.

      (a) Right to Include Registrable Shares. If at any time and from time to
time the Company proposes to register any shares of its capital stock under the
Securities Act, whether or not for sale for its own account, on a form and in
the manner that would permit registration of Registrable Shares for the sale to
the public under the Securities Act, the Company will give written notice to all
Holders of its intention to do so. Upon the written request of a Holder given
within 20 days after the giving of any such notice by the Company, the Company
will use its best efforts to cause to be included in such Registration Statement
all of the Registrable Shares so requested for inclusion by Holders. If the
Registration Statement is to cover, in whole or in part, any underwritten
distribution, the Company shall use its best efforts to cause the Registrable
Shares requested for inclusion pursuant to this Section 2 to be included in the
underwriting on the same terms and conditions (including any lock-up) as the
Registrable Shares otherwise being sold through the underwriters.

      (b) Priority in Incidental Registrations. If, in the good faith judgment
of the managing underwriter of any underwritten offering, the inclusion of all
of the Registrable Shares requested for inclusion pursuant to this Section 2
would materially and adversely affect the successful marketing of the proposed
offering, then the number of shares of capital stock and Registrable Shares, if
any, to be included in such registration shall be reduced, such reduction shall
be applied, first, by excluding (on a pro rata basis) capital stock of the
Company to be sold by persons other than the Company and the Holders and second,
by excluding (on a pro rata basis) Registrable Shares proposed to be sold by all
Holders, provided, that notwithstanding the foregoing the Holders shall be
allocated at least one third of the total shares being included in such
offering. Notwithstanding the foregoing provisions, the Company may withdraw any
registration statement referred to in this Section 2 without incurring any
liability to Holders of the Registrable Shares.

                                      -3-
<PAGE>

      2A. Registrations on Form S-3. If at any time the Company shall qualify
for the use of Form S-3 promulgated under the Securities Act or any successor
form thereto, the Holders of the Registrable Shares then outstanding shall have
the right to request in writing an unlimited number of registrations of
Registrable Shares having a minimum aggregate offering price of at least
$1,000,000 on Form S-3 or such successor form, which request or requests shall
(i) specify the number of Registrable Shares intended to be sold or disposed of
and the Holders thereof, (ii) state the intended method of disposition. A
requested registration on Form S-3 or any successor form pursuant to this
Section 2A shall not count as a registration initiated pursuant to Section 1,
but shall otherwise be treated as a registration initiated pursuant to, and
shall, except as otherwise provided in this Section 2A, be subject to the
limitations and restrictions in Section 1.

      3. Registration Procedures. If and whenever the Company is required by the
provisions of Section 1 or 2 to effect the registration of the Registrable
Shares under the Securities Act, the Company will:

      (a) prepare and file with the Commission a Registration Statement with
respect to such Registrable Shares and use reasonable efforts to cause such
Registration Statement to become effective; provided that the Company may
discontinue any registration of its securities which is being effected pursuant
to Section 2 at any time prior to the effective date of the Registration
Statement; provided, further, that, with respect to a registration under Section
1 (A) if the Company is eligible to use Form S-3 with regard to a Registration
Statement, such Registration Statement be filed within 60 days after a request
for registration has been delivered to the Company, (B) such Registration
Statement, other than on Form S-3 and other than with respect to the Initial
Public Offering, be filed within 90 days after a request for registration has
been delivered to the Company and (C) the Registration Statement with respect to
the Initial Public Offering be filed within 120 days after a request for
registration has been delivered to the Company.

      (b) prepare and file with the Commission such amendments and supplements
to any Registration Statement referred to in Section 3(a) and the prospectus
used in connection therewith as may be necessary to keep such Registration
Statement effective for a period not in excess of 90 days (except with respect
to any Registration Statement filed pursuant to Rule 415 under the Securities
Act if the Company is eligible to file a Registration Statement on Form S-3, in
which case the Company shall use reasonable efforts to keep such Registration
Statement effective and updated until such time as all of the Registrable Shares
have been disposed of in accordance with the intended methods of disposition by
the Holder or Holders set forth in such Registration Statement) and to comply
with the provisions of the Securities Act with respect to the disposition of all
Registrable Shares covered by such Registration Statement during such period in
accordance with the intended methods of disposition by the seller or sellers
thereof set forth in such Registration Statement; provided that at least five
days before filing a Registration Statement or prospectus, or any amendments or
supplements thereto, the Company will furnish to one counsel selected by the
Holders holding a majority of the Registrable Shares covered by such
Registration Statement to represent all Holders of Registrable Shares covered by
such Registration Statement ("Holders' Counsel"), copies of all documents
proposed to be filed, which documents will be subject to the review of such
counsel;

                                      -4-
<PAGE>

      (c) if such Registrable Shares have not been registered under Section 12
of the Securities Exchange Act of 1934 (the "Exchange Act"), prepare and file
with the Commission a registration statement with respect to such Registrable
Shares under the Exchange Act (an "Exchange Act Registration Statement") and use
reasonable efforts to cause such Exchange Act Registration Statement to become
effective; provided that the Company may discontinue any registration of its
securities which is being effected pursuant to Section 2 at any time prior to
the effective date of the Exchange Act Registration Statement; provided,
further, that, with respect to a registration under Section 1 (A) if the Company
is eligible to use Form S-3 with regard to a Registration Statement, such
Exchange Act Registration Statement be filed within 60 days after a request for
registration has been delivered to the Company, (B) such Exchange Act
Registration Statement, other than an Exchange Act Registration Statement
relating to a Registration Statement on Form S-3 and other than with respect to
the Initial Public Offering, be filed within 120 days after a request for
registration has been delivered to the Company and (C) the Exchange Act
Registration Statement with respect to the Initial Public Offering be filed
within 180 days after a request for registration has been delivered to the
Company;

      (d) furnish to each seller of such Registrable Shares such number of
copies of any Registration Statement referred to Section 3(a) and of each
amendment and supplement thereto (in each case including all exhibits), such
number of copies of the prospectus included in such Registration Statement
(including each preliminary prospectus and summary prospectus), and any other
prospectus filed under Rule 424 under the Securities Act in conformity with the
requirements of the Securities Act, such number of copies of any Exchange Act
Registration Statement referred to in Section 3(c) and such other documents as
such seller may reasonably request;

      (e) use reasonable efforts to register or qualify such Registrable Shares
covered by any Registration Statement referred to in Section 3(a) under such
other securities or blue sky laws of such jurisdictions as each seller of such
Registrable Shares shall reasonably request, and do any and all other acts and
things which may be necessary or advisable to enable such seller to consummate
the disposition in such jurisdictions of the Registrable Shares owned by such
seller, except that the Company shall not for any such purpose be required to
qualify generally to do business as a foreign corporation in any jurisdiction
where, but for the requirements of this Section 3(e), it would not be obligated
to be so qualified or to consent to general service of process in any such
jurisdiction;

      (f) use reasonable efforts to cause such Registrable Shares covered by a
Registration Statement to be registered with or approved by such other
governmental agencies or authorities as may be necessary to enable the seller or
sellers thereof to consummate the disposition of such Registrable Shares;

      (g) notify each seller of any such Registrable Shares covered by a
Registration Statement, at any time when a prospectus relating thereto is
required to be delivered under the Securities Act, of the Company's becoming
aware that the prospectus included in such Registration Statement, as then in
effect, includes an untrue statement of a material fact or omits to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading in the light of the circumstances then existing, and at
the request of any such seller, prepare and furnish to such seller a reasonable
number of copies of an amended or supplemental prospectus as may be necessary so
that, as thereafter delivered to the sellers of such Registrable Shares, such
prospectus shall not include an untrue statement of a material fact or omit to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then
existing;

                                      -5-
<PAGE>

      (h) use reasonable efforts to list such Registrable Shares on any
securities exchange or automated quotation system if (i) requested by the
Holders of a majority of such Registrable Shares and (ii) such listing is then
permitted under the rules of such exchange or system; provided, however, that if
the Common Stock is listed on a national securities exchange or on an automated
quotation system at the time of the effectiveness of any Registration Statement
relating to such Registrable Shares, the Company shall only be obligated to list
the Registrable Shares on such exchange or system, and to provide a transfer
agent and registrar for such Registrable Shares covered by a Registration
Statement not later than the effective date of such Registration Statement;

      (i) enter into such customary agreements (including an underwriting
agreement in customary form) and take such other actions as sellers of a
majority of such Registrable Shares or the underwriters, if any, reasonably
request in order to expedite or facilitate the disposition of such Registrable
Shares;

      (j) use reasonable efforts to obtain a "cold comfort" letter or letters
from the Company's independent public accountants in customary form and covering
matters of the type customarily covered by "cold comfort" letters as the seller
or sellers of a majority of such Registrable Shares shall reasonably request;

      (k) obtain an opinion of counsel for the Company in customary form and
covering matters of the type customarily covered in opinions of issuer's counsel
as the managing underwriter or, if none, the seller or sellers of a majority of
such Registrable Shares shall reasonably request;

      (l) make available for inspection by any seller of such Registrable Shares
covered by a Registration Statement, by any underwriter participating in any
disposition to be effected pursuant to such Registration Statement and by any
attorney, accountant or other agent retained by any such seller or any such
underwriter, all pertinent financial and other records, pertinent corporate
documents and properties of the Company, and cause all of the Company's
officers, directors and employees to supply all information reasonably requested
by any such seller, underwriter, attorney, accountant or agent in connection
with such Registration Statement, subject to the execution of a confidentiality
or non-disclosure agreement reasonably acceptable to the Company; and

      (m) upon receipt of certificates evidencing such Holders' Registrable
Shares, issue new certificates to any underwriter or purchaser to which the
Holders holding such Registrable Shares may sell shares in such offering.

      4. Expenses. With respect to each registration effected pursuant to
Section 1, 2 or 2A, all Registration Expenses (defined below) in connection with
such registration and the public offering in connection therewith shall be borne
by the Company. "Registration Expenses" shall mean any and all expenses (other
than underwriting discounts and commissions) incident to performance of or

                                      -6-
<PAGE>

compliance with this Agreement, including, without limitation, (i) all
registration and filing fees of the Commission or the National Association of
Securities Dealers, Inc., (ii) all fees and expenses of complying with
securities or blue sky laws (including fees and disbursements of counsel in
connection with blue sky qualifications of the Registrable Shares), (iii) all
printing, messenger and delivery expenses, (iv) all fees and expenses incurred
in connection with the listing of the Registrable Shares on any securities
exchange or automated quotation system pursuant to Section 3(h), (v) the fees
and disbursements of counsel for the Company and of its independent public
accountants, including the expenses of any special audits and/or "cold comfort"
letters required by or incident to such performance and compliance, (vi) the
reasonable fees and disbursements of one Holders' Counsel; and (vi) any fees and
disbursements of underwriters customarily paid by the issuers or sellers of
securities, including fees and disbursements of counsel for the underwriters,
but excluding underwriting discounts and commissions. All fees and disbursement
of counsel and accountants for the Holders, underwriting discounts and
commissions and transfer taxes for the Holders and any other expenses incurred
by the Holders not expressly included above shall be borne by the Holders.

      5. Indemnification and Contribution.

      (a) Indemnification by the Company. In the event of a registration of any
Registrable Shares pursuant to Section 1, 2 or 2A, the Company will indemnify
and hold harmless each Holder of such Registrable Shares included in a
Registration Statement pursuant to the provisions of this Agreement and any
underwriter for the offering of such Registrable Shares, and their respective
Affiliates, and each of their successors from and against, and will reimburse
such Holder, underwriter and Affiliate with respect to, any and all claims,
actions, demands, losses, damages, liabilities, costs and expenses, as incurred,
to which such Holder, underwriter or Affiliate may become subject under the
Securities Act, the Exchange Act or otherwise, including the reasonable fees and
expenses of legal counsel (including those incurred in connection with any claim
for indemnity hereunder) insofar as such claims, actions, demands, losses,
damages, liabilities, costs or expenses (or actions, or proceedings, whether
commenced or threatened in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained in
such Registration Statement, any prospectus contained therein or any amendment
or supplement thereto, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances in which
they are made, not misleading or arise out of any violation by the Company of
any rule or regulation under the Securities Act, the Exchange Act or any state
securities laws applicable to the Company and relating to action or inaction
required of the Company in connection with such registration; provided that the
Company will not be liable in any case to the extent, but only to the extent,
that any such claim, action, demand, loss, damage, liability, cost or expense
arises out of or is based upon an untrue statement or omission made in reliance
upon and in strict conformity with information furnished by such Holder or such
underwriter in writing specifically for use in the preparation thereof. This
indemnity shall remain in full force and effect regardless of any investigation
made by or on behalf of such Holder, underwriter or Affiliate and shall survive
the transfer of such securities by such Holder or such underwriter.

                                      -7-
<PAGE>

      (b) Indemnification by the Holders. Each Holder of Registrable Shares,
severally and not jointly, which Registrable Shares are included in a
registration pursuant to the provisions of this Agreement, will indemnify and
hold harmless the Company, each person, if any, who controls the Company within
the meaning of the Securities Act, each officer of the Company who signs the
Registration Statement including such Registrable Shares, each director of the
Company, each underwriter and any person who controls the underwriter and each
of their successors from and against, and will reimburse the Company and such
officer, director, underwriter or controlling person with respect to, any and
all claims, actions, demands, losses, damages, liabilities, costs or expenses,
as incurred, to which the Company or such officer, director, underwriter or
controlling person may become subject under the Securities Act, the Exchange Act
or otherwise, insofar as such claims, actions, demands, losses, damages,
liabilities, costs or expenses arise out of or are based upon any untrue
statement of any material fact contained in such Registration Statement, any
prospectus contained therein or any amendment or supplement thereto, or arise
out of or are based upon the omission to state therein a material fact required
to be stated therein or necessary to make the statements therein, in light of
the circumstances in which they are made, not misleading; provided that such
Holder will be liable in any such case to the extent, but only to the extent,
that any such claim, action, demand, loss, damage, liability, cost or expense
arises primarily out of or is based primarily upon an untrue statement or
omission made in reliance upon and in strict conformity with written information
furnished by such Holder specifically for use in the preparation thereof. The
liability of each Holder under this Section shall be limited to the proportion
of any such claim, action, demand, loss, damage, liability, cost or expense
which is equal to the proportion that the public offering price of the
Registrable Shares sold by such Holder under such registration statement bears
to the total offering price of all securities sold thereunder, but not, in any
event, to exceed the net proceeds received by such Holder from the sale of
Registrable Shares covered by such Registration Statement. This indemnity shall
survive the transfer of such securities by such Holder and the underwriter.

      (c) Notices of Claims, etc. Promptly after receipt by a party to be
indemnified pursuant to the provisions of Section 5(a) or 5(b) (an "indemnified
party") of notice of the commencement of any action involving the subject matter
of the foregoing indemnity provisions, such indemnified party will, if a claim
thereof is to be made against the indemnifying party pursuant to the provisions
of Section 5(a) or 5(b) (an "indemnifying party"), notify the indemnifying party
of the commencement thereof, but the omission to so notify the indemnifying
party will not relieve it from any liability which it may have to an indemnified
party otherwise than under this Section 5 and shall not relieve the indemnifying
party from liability under this Section 5 unless, and to the extent, such
indemnifying party is prejudiced by such omission. In case such action is
brought against any indemnified party and it notifies the indemnifying party of
the commencement thereof, the indemnifying party shall have the right to
participate in, and, to the extent that it may wish, jointly with any other
indemnifying party similarly notified, to assume the defense thereof, with
counsel reasonably satisfactory to such indemnified party, and after the notice
from the indemnifying party to such indemnified party of its election to assume
the defense thereof, the indemnifying party will not be liable to such
indemnified party pursuant to the provisions of this Section 5(a) and 5(b) for
any legal expense subsequently incurred by such indemnified party in connection
with the defense thereof other than reasonable costs of investigation; provided
that, if the defendants in any such action include both the indemnified party
and the indemnifying party and the indemnified party shall have reasonably
concluded that there may be reasonable defenses available to it that are
different from or additional to those available to the indemnifying party or if

                                      -8-
<PAGE>

the interests of the indemnified party reasonably may be deemed to conflict with
the interests of the indemnifying party, the indemnified party shall have the
right to select a separate counsel and to assume such legal defenses and
otherwise to participate in the defense of such action, with the expenses and
fees of such separate counsel and other expenses related to such participation
to be reimbursed by the indemnifying party as incurred. No indemnifying party
shall be liable to an indemnified party for any settlement of any action or
claim without the consent of the indemnifying party and no indemnifying party
may unreasonably withhold its consent to any such settlement. No indemnifying
party will, except with the consent of the indemnified party, consent to entry
of any judgment or enter into any settlement which does not include as an
unconditional term thereof the giving by the claimant or plaintiff to such
indemnified party of a release from all liability and equitable claims in
respect to such claim or litigation.

      (d) Contribution. In order to provide for just and equitable contribution
to joint liability under the Securities Act in any case in which either (i) any
Holder exercising rights under this Agreement or any underwriter makes a claim
for indemnification pursuant to this Section but it is judicially determined (by
the entry of a final judgment or decree by a court of competent jurisdiction and
the expiration of time to appeal or the denial of the last right of appeal) that
such indemnification may not be enforced in such case notwithstanding the fact
that this Section 5 provides for indemnification in such case, or (ii)
contribution under the Securities Act may be required on the part of any such
Holder or underwriter, as the case may be, in circumstances for which
indemnification is provided under this Section 5, then, and in each such case,
the Company on the one hand and such Holder or underwriter, as the case may be,
on the other, will contribute to the aggregate claims, actions, demands, losses,
damages, liabilities, costs or expenses to which they may be subject (after
contribution from others) in such proportion as is appropriate to reflect the
relative fault of the Company on the one hand and of the Holder of Registrable
Shares or the underwriter, as the case may be, on the other, in connection with
the statements or omissions that resulted in such claims, actions, demands,
losses, damages, liabilities, costs or expenses, as well as any other relevant
equitable considerations. The relative fault of the Company on the one hand and
of the Holder of Registrable Shares or the underwriter, as the case may be, on
the other, shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or omission or alleged
omission to state a material fact relates to information supplied by the Company
on the one hand or by the Holder of Registrable Shares or the underwriter, as
the case may be, on the other, and each party's relative intent, knowledge,
access to information and opportunity to correct or prevent such statement or
omission; provided that, in any such case, (x) no person or entity guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the
Securities Act) will be entitled to contribution from any person or entity who
was not guilty of such fraudulent misrepresentation and (y) no such Holder or
underwriter will be required to contribute any amount in excess of the proceeds
received by such Holder or underwriter, as the case may be, from the sales of
Registrable Shares covered by the Registration Statement.

      (e) Other Indemnification. Notwithstanding the foregoing, to the extent
that the provisions on indemnification and contribution contained in the
underwriting agreement entered into in connection with the underwritten public
offering are in conflict with the foregoing provisions, the provisions in the
underwriting agreement shall control.

                                      -9-
<PAGE>

      6. Shareholder Information. The Company may require each Holder of
Registrable Shares as to which any registration is to be effected pursuant to
this Agreement to furnish the Company in a timely manner such information with
respect to such Holder and the distribution of such Registrable Shares as the
Company may from time to time reasonably request in writing and as shall be
required by law or by the Commission.

      7. "Market Stand-Off" Agreement. Each Holder hereby agrees that, during
the period of duration specified (not to exceed 180 days) by the Company and an
underwriter of Common Stock or other securities of the Company, following the
effective date of a Registration Statement of the Company filed under the
Securities Act, it shall not, to the extent requested by the Company and such
underwriter, directly or indirectly sell, offer to sell, contract to sell
(including, without limitation, any short sale), grant any option to purchase or
otherwise transfer or dispose of (other than to donees who agree to be similarly
bound) any securities of the Company held by it at any time during such period
except Registrable Shares. The Company shall obtain the agreement of any person
permitted to sell shares of stock in a registration to be bound by and to comply
with the terms of this Section 7 as if such person was a Holder hereunder. In
the event the Company fails to obtain such agreement of the Company's officers
and directors then holding outstanding shares, the restrictions set forth in
this Section 7 shall cease to apply to the Holders.

      7A. Additional Parties. In it's sole discretion, the Company may (but in
no event shall be required to) permit the purchasers of up to an additional
2,000,000 shares (as adjusted for any stock dividends, stock splits and similar
events) of Common Stock of the Company issued after the date of this Agreement,
or issuable upon conversion of convertible securities issued after the date of
this Agreement (the "Additional Shares"), to become parties to this Agreement
and have such Additional Shares become Registrable Shares subject to the terms
of this Agreement, provided that (i) the Company consents in writing thereto;
(ii) such purchasers execute an Addendum(s) to this Agreement in the form of
Annex A attached hereto; and (iii) the Investor and each other Holder receives
notice of such additional parties and a copy of each such Addendum(s). If so
added, such purchasers shall become Holders entitled to the rights and subject
to the obligations as set forth in this Agreement with the same force and effect
as though such purchasers had executed this Agreement as a signatory party.

      8. Miscellaneous

      (a) Specific Enforcement. All of the parties acknowledge that the parties
will be irreparably damaged in the event that this Agreement is not specifically
enforced. Upon a breach or threatened breach of the terms, covenants or
conditions of this Agreement by any of the parties hereto, the other parties
shall, in addition to all other remedies, be entitled to a temporary or
permanent injunction, without showing any actual damage, or a decree for
specific performance, in accordance with the provisions of this Agreement.

      (b) Descriptive Headings; Definitions; Certain Interpretations.

            (i) Descriptive headings are for convenience only and shall not
      control or affect the meaning or construction of any provision of this
      Agreement.

                                      -10-
<PAGE>

            (ii) As used in this Agreement, the following terms shall have the
      following respective meanings:

            "Affiliate" means (A) any person or entity directly or indirectly
      controlling, controlled by or under common control with another person or
      entity; (B) any person or entity owning or controlling 10% or more of the
      outstanding voting securities of such other person or entity; (C) any
      partner, officer, director, employee or shareholder of such entity or any
      parent, spouse, child, brother, sister or other relative with a
      relationship (by blood, marriage or adoption) not more remote than first
      cousin of any of the foregoing; or (D) any liquidating trust, trustee or
      other similar person or entity for any such person or entity.

            "Holder" means a registered or beneficial owner of the Registrable
      Shares.

            "Initial Public Offering" means the initial public offering of
      shares of Common Stock pursuant to registration under the Securities Act.

            "Registrable Shares" means (a) 3,101,190 shares of Common Stock
      purchased by Investor prior to November 1, 2002 (as may be adjusted
      pursuant to Section 1(b) of the Purchase Agreement or pursuant to any
      stock dividends, stock splits or similar events), (b) up to an additional
      2,000,000 shares of Common Stock of the Company (as adjusted for any stock
      dividends, stock splits and similar events) sold after the date of this
      Agreement, or issuable upon conversion of convertible securities sold
      after the date of this Agreement, that becomes subject to this Agreement
      pursuant to Section 7A and (c) any securities issued in respect of any
      such shares of Common Stock by way of a stock dividend or stock split or
      in connection with a combination of shares, recapitalization, merger or
      consolidation or reorganization; provided that, such securities shall
      cease to be Registrable Shares when such securities have been sold to or
      through a broker or dealer or underwriter in a public distribution or a
      public securities transaction or in a transaction under Rule 144(k) under
      the Securities Act.

      (c) Interpretation. Except as otherwise expressly provided in this
Agreement, the following rules of interpretation apply to this Agreement: (i)
the singular includes the plural and the plural includes the singular; (ii) "or"
or "any" are not exclusive and "include" and "including" are not limiting; (iii)
a reference to any agreement or other contract includes permitted supplements
and amendments; (iv) a reference to a law includes any amendment or modification
to such law and any rules or regulations issued thereunder; (v) a reference to a
person or entity includes its successors and assigns; and (vi) a reference in
this Agreement to a Section is to the Section of this Agreement.

      (d) Notices. All notices, requests and other communications to any party
hereunder shall be in writing and sufficient if delivered personally or sent by
facsimile telecopy (with confirmation of receipt) or by registered or certified
mail, postage prepaid, return receipt requested, addressed as follows:

                                      -11-
<PAGE>

      If to the Company:            BioForce Nanosciences, Inc.
                                    2901 S. Loop Drive
                                    Ames, Iowa  50010
                                    Attention: Gary A. Alianell
                                    President and Chief Executive Officer
                                    Facsimile: (515) 296-6570

      If to the Investor:           FCPR SGAM BIOTECHNOLOGY FUND
                                    Duly represented by its management company
                                    Societe Generale Asset Management
                                    2, place de la Coupole
                                    92400 Courbevoie
                                    France
                                    Attention: Jean Grimaldi
                                    Facsimile: 33 1 56 37 86 47

       If to any other Holder:      To the address set forth on the Addendum
                                    signed by such Holder.

or to such other address or facsimile number as the parties to whom notice is to
be given may have furnished to the other parties in writing in accordance
herewith. Each such notice, request or communication shall be effective when
received or, if given by mail, when delivered at the address specified in this
Section or on the fifth business day following the date on which such
communication is posted, whichever occurs first.

      (e) Counterparts. This Agreement may be executed in any number of
counterparts, and each such counterpart hereof shall be deemed to be an original
instrument, but all such counterparts together shall constitute but one
agreement.

      (f) Benefits of Agreement. All of the terms and provisions of this
Agreement shall be binding upon and inure to the benefit of the parties hereto
and their respective successors and assigns. This Agreement is for the sole
benefit of the parties hereto and not for the benefit of any third party except
as set forth in Sections 7A and 8(i).

      (g) Enforceability. It is the desire and intent of the parties hereto that
the provisions of this Agreement shall be enforced to the fullest extent
permissible under the laws and public policies applied in each jurisdiction in
which enforcement is sought. Accordingly, if any particular provision of this
Agreement shall be adjudicated to be invalid or unenforceable, such provision
shall be deemed amended to delete therefrom the portion thus adjudicated to be
invalid or unenforceable, such deletion to apply only with respect to the
operation of such provision in the particular jurisdiction in which such
adjudication is made.

      (h) GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH THE LAWS OF THE STATE OF IOWA (WITHOUT GIVING EFFECT TO ANY
CHOICE OR CONFLICT OF LAWS PROVISIONS).

      (i) Waivers; Amendments. No waiver of any right hereunder by any party
shall operate as a waiver of any other right, or of the same right with respect
to any subsequent occasion for its exercise, or of any right to damages. No
waiver by any party of any breach of this Agreement shall be held to constitute
a waiver of any other breach or a continuation of the same breach. All remedies
provided by this Agreement are in addition to all other remedies provided by
law. This Agreement may not be amended except by a writing executed by the
Company and by Holders holding at least 51% of the Registrable Shares; provided
that the provisions of this Section 8(i) may not be amended unless such
amendment is executed by each Holder.

                                      -12-
<PAGE>

      (j) Successors and Assigns. This Agreement shall be binding upon and shall
inure to the benefit of the parties hereto and their respective successors and
permitted assigns. This Agreement may not be assigned by the Company. The
Investor's rights are assignable to any assignee or transferee of all or a
portion of the Registrable Shares held by the Investor. In addition, and whether
or not any express assignment shall have been made, the provisions of this
Agreement which are for the benefit of the parties hereto other than the Company
shall also be for the benefit of and enforceable by any subsequent Holder of any
Registrable Shares, subject to the provisions contained herein.

      (k) Termination. This Agreement shall terminate on the date the Holders
own less than five percent (5%) of the initial Registrable Shares.

      (l) Entire Agreement. This Agreement contains the entire agreement among
the parties with respect to the transactions contemplated by this Agreement and
supersedes all prior agreements or understandings among the parties.

                                      -13-
<PAGE>

      IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                       BIOFORCE NANOSCIENCES, INC.

                                       By: /s/ Gary A. Alianell, Ph.D.
                                           -------------------------------------
                                           Gary A. Alianell, Ph.D.
                                           President and Chief Executive Officer

                                       FCPR SGAM BIOTECHNOLOGY FUND by its
                                       management company SOCIETE GENERALE ASSET
                                       MANAGEMENT

                                       By: /s/ Jean Grimaldi
                                           -------------------------------------
                                           Jean Grimaldi
                                           Head of Private Equity

                                      -14-
<PAGE>

                                     ANNEX A

Pursuant to the Amended and Restated Registration Rights Agreement (the
"Agreement") dated as of October    , 2002 by and among BioForce Nanosciences,
Inc., a Delaware corporation (the "Company"), FCPR SGAM BIOTECHNOLOGY FUND, an
investment fund organized under the laws of France (the "Investor"), duly
represented by its management company Societe Generale Asset Management, and
such persons or entities that become parties to this Agreement as permitted
pursuant to Section 7A thereof, the undersigned, now the holder of ___________
shares of Common Stock evidenced by certificate(s) numbered ______________, does
hereby become a party to such Agreement and entitled to the rights and subject
to the obligations as set forth therein with the same force and effect as though
the undersigned had executed said Agreement as a signatory party thereto. The
undersigned acknowledges that he or she has read said Agreement and is familiar
with and understands its terms. A copy of said Agreement is attached hereto as
Exhibit "A."

Dated this ____ day of ________________, 200 __.

Shareholder Name: _____________

By: _____________________________________
    (Name)
    (Title)

    Address:   __________________________
               ____________,____ ________
    Attention: __________________________
    Facsimile: (____) _____-_____________

Consented to this _____ day of _____________, 200__.

BIOFORCE NANOSCIENCES , INC.

By: ______________________________
Name: ____________________________
Title: ___________________________[LETTERHEAD OF BIOFORCE NANOSCIENCES]

                                                       September 6, 2006

BioForce Nanosciences Holdings, Inc.
1615 Golden Aspen Drive
Suite 101
Ames, Iowa 50010

      Re: Lock-up / Leak-out Agreement - [name of stockholder]

Gentlemen:

      Please be advised that I desire to have my shares of common stock of
BioForce Nanosciences Holdings, Inc., a Nevada corporation (the "Company"), as
designated below, included in the Company's proposed registration statement to
be filed with the Securities and Exchange Commission ("SEC") pursuant to the
Securities Act of 1933 (the "Securities Act").

      My shares of the Company's common stock that will be subject to this
letter are represented by the stock certificate(s) depicted below, which are
registered in my name and/or beneficially owned by me (the "Shares").

      In order to assist in fulfilling the Company's intended corporate
endeavors and to help in maintaining an orderly public trading market, I hereby
agree that commencing on the date the registration statement is declared
effective by the SEC (the "Effective Date"), I will abide by the following terms
in connection with my Shares:

      1. For a period of six (6) months from the Effective Date, I agree not to
      sell, transfer, pledge or otherwise dispose of more than ten percent (10%)
      of the beneficial interest in the total number of my Shares indicated
      below.

      2. For the period commencing six (6) months from the Effective Date and
      for the six (6) months immediately thereafter, I agree not to sell,
      transfer, pledge or otherwise dispose of more than ten percent (10%) of
      the beneficial interest in the total number of my Shares indicated below.

      3. Commencing one (1) year following the Effective Date of the proposed
      registration statement, the lock-up provisions of this letter will no
      longer apply and I will be permitted to sell my Shares, except as may be
      otherwise prohibited or restricted by the Securities Act and the rules and
      regulations promulgated thereunder.

      I hereby acknowledge that the 10% permitted to be sold in the first six
months from the Effective Date is not cumulative with the second six month
period. Therefore, regardless of the number of shares sold during the first six
months (no more than 10% of the Shares), the maximum permitted to be sold in the
second six months will be 10% of the number of Shares depicted below.

      In order to enable the aforesaid covenants, I hereby consent to the
Company's transfer agent placing appropriate restrictive legends on the
certificate(s) representing my Shares and/or stop-transfer orders with respect
to the stock certificate(s) representing the Shares.

      By affixing my signature to this letter, I hereby agree to permit my
Shares to be included in the Company's proposed registration statement and also
agree to accept and abide by the terms and conditions set forth above. I further
agree to comply with any and all other rules and regulations of the Securities
Act that may be applicable to the Company's registration statement and to the
execution of this letter.

Dated:___________________________

                                              __________________________________
                                              Signature

Number of shares:________________             __________________________________
Certificate No.:_________________             Name (please print)

Acknowledged and agreed to by:
BioForce Nanosciences Technologies, Inc.

By:______________________________
   Eric Henderson, CEO

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}]]