Document:

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                                                                   EXHIBIT 10.45

                  EXCLUSIVE MARKET ACCESS AND SUPPLY AGREEMENT

      THIS EXCLUSIVE MARKET ACCESS AND SUPPLY AGREEMENT (the "Agreement") is
made as of September 21, 2001, (the "Effective Date") by and between:

      ENDOCARE, INC., a corporation organized and existing under the laws of the
State of Delaware, USA, with its principal offices at 7 Studebaker, Irvine, CA
92618, ("ENDOCARE")

      AND

      CRYOCATH TECHNOLOGIES INC., a corporation organized and existing under the
laws of Quebec, Canada, with its principal offices at 16771 Chemin Ste-Marie,
Kirkland, Quebec, Canada H9H 5H3 ("CryoCath").

WITNESSETH:

      WHEREAS ENDOCARE develops, manufactures and commercializes medical devices
and has specific Argon-based cryosurgical probe and Cryo-Console development
expertise;

      WHEREAS CryoCath develops, manufactures, markets and distributes various
cryotherapy devices and systems which treat cardiovascular diseases including
ventricular and atrial arrhythmias;

      WHEREAS ENDOCARE wishes to supply CryoCath with certain products and with
rights to create a market for and distribute certain cryoablation systems and
devices manufactured by ENDOCARE on an exclusive worldwide basis; and

      WHEREAS the parties desire to enter into this Agreement for that purpose.

      NOW THEREFORE, in consideration of the representations, warranties,
covenants and agreements contained herein, and for other valuable consideration,
the receipt and adequacy of which is hereby acknowledged, the parties mutually
agree as follows:

                                      -1-

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                                    ARTICLE 1
                                   DEFINITIONS

SPECIFIC DEFINITIONS. As used in this Agreement, the following terms have the
meanings set forth or referenced below:

      "AFFILIATE" of a specified person (natural or juridical) means a person
      that directly or indirectly, through one or more intermediaries, controls,
      or is controlled by, or is under common control with, the person
      specified. "Control" shall mean ownership of more than 50% of the shares
      of stock entitled to vote for the election of directors in the case of a
      corporation, and more than 50% of the voting power in the case of a
      business entity other than a corporation.

      "CONFIDENTIAL INFORMATION" will refer to the definition set forth in
      Schedule 4 which is incorporated herewith.

      "CryoCath" means CryoCath Technologies Inc. and its Affiliates.

      "CRYOCATH TERRITORIES" means all territories worldwide subject to Section
      2.1(e) below.

      "ENDOCARE" means ENDOCARE, Inc. and its Affiliates.

      "FIELD OF USE" means accessing the heart surgically through the chest wall
      for the purpose of treating arrhythmias by the cardiovascular surgeon.

      "INTELLECTUAL PROPERTY" means all patents, trade names, trademarks,
      service marks, copyrights and applications or registrations for any of the
      foregoing, inventions, discoveries, know-how, trade secrets, data,
      information, technology, processes, formulas, drawings, designs, computer
      programs, licenses, and all amendments, modifications, and improvements to
      any of the foregoing.

      "SPECIFICATIONS" means the current performance specifications for the
      Systems, as may be amended from time to time hereafter by mutual agreement
      between ENDOCARE and CryoCath.

      "SYSTEMS" means all equipment and devices ENDOCARE has developed for
      performing surgical cryoablative procedures for the treatment of
      arrhythmias, including but not limited to Cryo-Consoles (as defined below)
      and single use probes using ENDOCARE's Argon Gas technology, together with
      such further developments, improvements and replacements to the Systems as
      described or contemplated herein.

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1.2   OTHER TERMS.

      (a)   Other terms may be defined elsewhere in the text of this Agreement
            and shall have the meaning indicated throughout this Agreement.

1.3   OTHER DEFINITIONAL PROVISIONS.

      (a)   The words "hereof," "herein," and "hereunder" and words of similar
            import, when used in this Agreement, shall refer to this Agreement
            as a whole and not to any particular provisions of this Agreement.

      (b)   The terms defined in the singular shall have a comparable meaning
            when used in the plural, and vice versa.

      (c)   References to a "Schedule" are, unless otherwise specified, to one
            of the Schedules attached to or referenced in this Agreement, and
            references to an "Article" or a "Section" are, unless otherwise
            specified, to one of the Articles or Sections of this Agreement.

      (d)   The term "person" includes any individual, partnership, joint
            venture, corporation, trust, unincorporated organization or
            government or any department or agency thereof.

      (e)   The term "Dollars" or "$" shall refer to the currency of the United
            States of America.

      (f)   The term "knowledge" means actual knowledge of a fact or the
            knowledge which such person or its officers or employees could
            reasonably be expected to have based on reasonable investigation and
            inquiry.

      (g)   All references to time shall refer to Montreal time.

      (h)   "Cryo-Console" shall mean the cryoablation unit specified in
            Schedule 1.

      (i)   "annual period" shall mean consecutive twelve month periods, the
            first of which commences on the date that the malleable cryoprobe is
            approved for sale in the United States and the European Community
            and made available to CryoCath by ENDOCARE as specified in Section
            2.9 (g), and each subsequent twelve month period thereafter.

      (j)   "European Community" shall mean all of the countries in the European
            Community from time to time.

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                                    ARTICLE 2
              CRYOCATH AS EXCLUSIVE WORLDWIDE MARKET ACCESS PARTNER

2.1 APPOINTMENT.

      (a)   ENDOCARE hereby appoints CryoCath, and CryoCath hereby accepts
            appointment, as ENDOCARE's market access partner having the sole and
            exclusive right to market, sell and distribute the Systems in the
            Field of Use in the CryoCath Territories. ENDOCARE represents and
            warrants to CryoCath that all other marketing, distribution or sales
            representative agreements, if any, written or oral, with any third
            party permitting the sale of Systems in the Field of Use in the
            CryoCath Territories have been terminated at ENDOCARE's sole cost
            and expense.

      (b)   CryoCath may appoint sub-distributors for the sale or distribution
            of Systems in the Field of Use in the CryoCath Territories.
            Notwithstanding such appointment of sub-distributors, CryoCath shall
            remain fully responsible for the performance of all of its covenants
            and obligations hereunder, and any sales by ENDOCARE to such
            CryoCath sub-distributors shall be billed by ENDOCARE to CryoCath
            directly. Without the pre-approval of ENDOCARE, there will be no
            changes made to the product, labeling, or changes or additions to
            the brand labeling on the SYSTEMS made by CryoCath's
            sub-distributors.

      (c)   ENDOCARE shall promptly forward to CryoCath all leads for sales or
            distribution of Systems in the Field of Use in the CryoCath
            Territories.

      (d)   During the term of CryoCath's exclusive distribution rights pursuant
            to this Article 2, CryoCath shall not market or sell products that
            compete in the Field of Use with the Systems, as defined herein, in
            the CryoCath Territories.

      (e)   At any time after the *** period of this Agreement, ENDOCARE may
            provide a written notice to CryoCath identifying a market where
            CryoCath has not commenced activity and indicating that CryoCath
            must develop the market by showing a plan of market entry and by
            initiating sales activity within *** of the notice by selling, at
            normal pricing, at least one Cryo-Console. In the event that
            CryoCath advises ENDOCARE in writing that it wishes to forego the
            market opportunity or if CryoCath does not develop the market as
            described above, the market will cease to form part of the CryoCath
            Territories.

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2.2   REGULATORY APPROVALS.

      (a)   ENDOCARE represents to CryoCath that it has and that it will
            maintain the necessary government approvals in the U.S.A. and the CE
            Mark in the European Community. In all other countries CryoCath will
            be responsible for obtaining regulatory approvals for the
            importation and marketing of the Systems. ENDOCARE will cooperate
            with CryoCath by providing all required documentation and System
            specifications short of specific animal or clinical data or clinical
            outcome results. ENDOCARE will pay for all expenses incurred in
            compiling documentation or performing bench testing to create
            performance specification data that may be required. CryoCath will
            be responsible for bearing all expenses associated with collecting
            any animal test results or clinical test results that may be
            required for gaining regulatory approval in CryoCath Territories as
            well as all other fees or expenses associated with gaining import or
            marketing approvals in CryoCath Territories. ENDOCARE will provide
            free of charge any Cryo-Console or cryoprobes required for testing
            to gain regulatory approvals at CryoCath's request. In cases where
            ENDOCARE supplies the Cryo-Console or cryoprobes free of charge,
            CryoCath will apply for product registration in the names of both
            CryoCath and ENDOCARE. CryoCath shall act as the ENDOCARE authorized
            representative in the CryoCath Territories when dealing with
            government and regulatory authorities.

      (b)   CryoCath will be responsible for all dealings with the appropriate
            competent authority such as notification, medical device vigilance
            and national labeling issues, provided that translation and
            preparation of such labels are subject to final review and
            verification by ENDOCARE, and to the mutual agreement of the
            parties. For purposes of this Section 2.2, labeling shall include
            labels, instructions for use, operating manuals, and service and
            maintenance manuals. CryoCath will be responsible for identifying
            the required documentation in all territories outside of the U.S.A.
            and the European Community (CE Mark) and for the cost of translation
            of English documents supplied by ENDOCARE at its sole cost including
            a Cryo-Console operator's manual and instructions on the proper use
            of the Cryo-Console and probes. ENDOCARE will be responsible for
            supplying all documentation necessary to obtain the regulatory
            approvals being sought by CryoCath outside the U.S.A. and the
            European Community (CE Mark). In all jurisdictions where CryoCath
            deals with the regulatory authorities, oversees the work, expends
            the funds necessary for obtaining regulatory approvals (including
            payment to ENDOCARE for any required Cryo-Consoles or cryoprobes and
            third party fees and out-of-pocket expenses, but excluding all
            required documentation from ENDOCARE), the approval will be
            registered solely in CryoCath's name or in the name of a third party
            designated by CryoCath and CryoCath shall be the sole owner of the
            regulatory

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            approval. In the event that CryoCath holds the registration solely
            in its name and wishes to sell or transfer such registration,
            CryoCath will provide Endocare with a first right of refusal to
            acquire the registration.

      (c)   As long as CryoCath maintains exclusivity under this Agreement, in
            all labeling and packaging, the CryoCath name will appear more
            prominently as the product will be sold under the CryoCath name.
            ENDOCARE's name shall appear as follows: "Manufactured by ENDOCARE
            exclusively for CryoCath Technologies Inc." CryoCath and ENDOCARE
            will work jointly following contract execution to design and develop
            mutually agreeable labelling.

2.3   LICENSE FEES.

      Subject to the terms of this Agreement, CryoCath will pay ENDOCARE license
fees as follows:

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                                       ***
                                       ***
                                       ***

2.4   PRICING AND PURCHASE REQUIREMENTS.

      (a)   During the term of this Agreement and any non-exclusive period
            hereunder, CryoCath will purchase the Systems from ENDOCARE at the
            prices set forth in Schedule 2 and at minimum volumes as set forth
            in Schedule 3. CryoCath will supply on a monthly basis a rolling
            12-month demand forecast, the first two months of each rolling
            12-month forecast is binding and constitutes a firm purchase
            commitment. ENDOCARE agrees that it will use reasonable efforts to
            supply products in accordance with the forecast. If ENDOCARE is more
            than 30 days late in the delivery of products, then CryoCath's
            Minimum Purchase Requirements shall be suspended for the period of
            any delay beyond 30 days.

      (b)   ENDOCARE will provide CryoCath with *** cryosurgical probes for use
            with the first *** patients treated in clinical trials for each of
            the malleable cryoprobe and the deflectable cryoprobe. Endocare will
            provide on *** sample cryoprobes of each new design and ***
            Cryo-Consoles prior to commercial availability.

      (c)   CryoCath shall be entitled to purchase from ENDOCARE a number of
            demonstration Cryo-Consoles and probes in the quantities and at the
            prices shown in Schedule 2.

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      (d)   Payments made by CryoCath for Systems purchased for resale by
            CryoCath pursuant to Article 2.4(a) shall be due and payable in full
            within thirty (30) days after the date of invoice. ENDOCARE will
            exercise reasonable efforts to deliver product in a timely manner
            per CryoCath orders as described in Section 2.9.

2.5   INSPECTION AND WARRANTY.

      (a)   Specifications for the Systems will be established by ENDOCARE
            subject to written agreement by CryoCath, and will be subject to
            modification from time to time by mutual agreement. In the event of
            any shortage, damage or discrepancy in or to a shipment of Systems
            or parts thereof or in the event any of the Systems fail to comply
            with the then current Specifications for the Systems, CryoCath shall
            report the same to ENDOCARE and furnish such written evidence or
            other documentation as ENDOCARE reasonably may deem appropriate. If
            the substantiating evidence delivered by CryoCath demonstrates that
            such shortage, damage or discrepancy or non-conformity with
            Specifications existed at the time of delivery of the Systems at the
            *** , CryoCath may return the Systems to ENDOCARE at ENDOCARE's
            expense, and ENDOCARE shall issue a credit or replacement for such
            returns at the invoiced price less any adjustments that may have
            been made based on actual annual purchase volumes. Any credit will
            be issued at the time that the returned product is received by
            ENDOCARE. ENDOCARE shall use reasonable efforts to promptly deliver
            replacement Systems to CryoCath in accordance with the delivery
            procedures set forth herein.

      (b)   ENDOCARE represents and warrants to CryoCath that all Systems sold
            and delivered under this Agreement will have been manufactured in
            accordance with FDA Good Manufacturing Practices, European Medical
            Device Directive requirements, ISO 9000 series certification, and
            all other applicable manufacturing requirements, and that
            continually during the term of this Agreement no Systems delivered
            by ENDOCARE to CryoCath shall be adulterated or misbranded at the
            time of delivery within the meaning of the U.S. Food, Drug and
            Cosmetic Act and regulations thereunder. ENDOCARE shall provide
            CryoCath's regulatory personnel with reasonable access from time to
            time, but not more than ***, to the facilities and records of
            ENDOCARE for the purpose of confirming ENDOCARE's compliance with
            all applicable requirements noted in this Article.

      (c)   ENDOCARE warrants to CryoCath and to CryoCath's customers that the
            Systems are in accordance with the warranty attached hereto as
            Section 2.5 (d). CryoCath shall bear all responsibility for, and
            shall indemnify and hold ENDOCARE harmless from any claim, action or
            loss which arises

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            out of or results from any other warranties made by CryoCath (other
            than ENDOCARE warranties) its employees or agents with respect to
            the Systems.

      (d)   THE PRODUCTS THAT ENDOCARE IS PROVIDING TO CRYOCATH ARE WARRANTIED
            ONLY TO THE EXTENT THAT THEY WILL BE FREE FROM DEFECT IN MATERIAL,
            DESIGN AND WORKMANSHIP. ENDOCARE MAKES NO OTHER WARRANTIES, EXPRESS,
            IMPLIED OR STATUTORY REGARDING THE PRODUCTS PROVIDED HEREUNDER
            INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY
            AND FITNESS FOR A PARTICULAR PURPOSE, WHICH ARE HEREBY EXPRESSLY
            DISCLAIMED. SUBJECT TO ENDOCARE'S EXPRESS REPRESENTATIONS AND
            WARRANTIES HEREIN, ENDOCARE DOES NOT REPRESENT THAT THE PRODUCTS
            WILL OPERATE ERROR-FREE, OR THAT THEY WILL OPERATE WITHOUT
            INTERRUPTION, OR THAT THEY WILL FUNCTION IN ACCORDANCE WITH
            CRYOCATH'S REQUIREMENTS. IN NO EVENT SHALL ENDOCARE HAVE ANY
            LIABILITY FOR, NOR SHALL ANY THIRD PARTY HAVE ANY REMEDY AGAINST
            ENDOCARE FOR, CONSEQUENTIAL DAMAGES, ANY LOSS OF PROFITS OR SAVINGS,
            LOSS OF USE, OR ANY OTHER COMMERCIAL LOSS.

2.6   MINIMUM PURCHASE REQUIREMENTS, SALES AND SERVICE.

      (a)   In addition to the fee payments set forth in Section 2.3, during the
            term of this Agreement, CryoCath agrees to certain minimum purchase
            requirements for cryoprobes and Cryo-Consoles as described in
            Schedule 3 (the "Minimum Purchase Requirements").

      (b)   CryoCath shall be responsible for selling all Systems in the Field
            of Use in the CryoCath Territories, provided that ENDOCARE shall be
            responsible for all repairs and servicing performed at the Endocare
            manufacturing facilities during the one year warranty period.
            ENDOCARE shall make available repair service on a contractual basis
            following the expiration of the one-year warranty period. ENDOCARE
            will carry sufficient inventory of spare parts to support rapid
            turnaround for repairs. ENDOCARE will also carry sufficient
            inventory of loaner Cryo-Consoles to meet customer need during the
            initial one-year warranty period and any subsequent years covered
            under service agreement where loaner units are included in the
            service agreement. Endocare will ship either the repaired unit or a
            loaner unit to customers within five (5) days of the date that the
            product returned for repair is received at ENDOCARE's facility. The
            replacement Cryo-Consoles and parts will be located in ENDOCARE's
            Irvine, California facility or, by mutual agreement at a

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            future U.S.-based CryoCath facility as may be appropriate. ENDOCARE
            may, at its option also inventory loaner Cryo-Consoles at CryoCath's
            European facility in Nieuwegein, The Netherlands.. The location of
            CryoCath's European facility may change at CryoCath's sole
            discretion.

      (c)   Subject to Article 2.8 below, CryoCath shall be solely responsible
            for providing customer and physician training to any purchaser of
            Systems for use in the Field of Use in the CryoCath Territories.

2.7   MARKETING.ERROR! BOOKMARK NOT DEFINED.

      (a)   CryoCath shall be solely responsible at its cost for the design and
            production of marketing, advertising and promotional materials for
            use in the CryoCath Territories. CryoCath shall be the sole end
            customer interface hereunder and sole owner of all customer lists.

      (b)   CryoCath shall be solely responsible for establishing the marketing,
            selling and pricing strategies for the Systems in the Field of Use
            in the CryoCath Territories.

      (c)   ENDOCARE shall have the right to review all marketing and
            promotional materials and approve them relative to the use of
            ENDOCARE trademarks or copywritten words or phrases.

2.8   TRAINING.

      (a)   During the first two annual periods, ENDOCARE will, *** , provide
            training personnel for *** training sessions for technical training
            of CryoCath's sales and field service representatives in the use,
            installation, trouble shooting and service of the Systems on such
            date and place as both CryoCath and ENDOCARE shall mutually agree.
            ENDOCARE will supply at *** all associated documentation for end
            user training including a Cryo-Console operator's manual and
            instructions on the proper use of the Cryo-Console and probes, all
            of which documentation shall be in English. ENDOCARE will pay for
            all facilities and related expenses provided that the training is
            conducted at ENDOCARE's Irvine facilities. CryoCath will provide and
            pay for the facilities and for any other associated expenses of any
            training outside of ENDOCARE's Irvine facilities. CryoCath will bear
            any travel expenses associated with CryoCath personnel's attendance
            at all such training. ENDOCARE shall also provide, ***, any
            additional training necessary with respect to any enhancements or
            modifications made by ENDOCARE to the System.

      (b)   Based on an initial training to CryoCath personnel as outlined
            above, CryoCath trained personnel will provide training for the
            "customer

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            trainers" (i.e. those CryoCath personnel and other third parties
            engaged in training customers at training sites) in the CryoCath
            Territories on such dates and at such places as CryoCath shall
            designate. CryoCath will bear the cost of such training and CryoCath
            will bear the costs associated with the CryoCath personnel and
            customers.

2.9   ORDERS.

      (a)   CryoCath and ENDOCARE shall jointly develop order and delivery
            procedures and guidelines for the Systems, including rolling
            forecasts as outlined in Section 2.4(a) above. CryoCath's orders
            shall be given no less favorable treatment by ENDOCARE than orders
            from customers in ENDOCARE's other business areas. Except for the
            first month of the first annual period, ENDOCARE will exercise
            reasonable efforts to ship CryoCath's orders within 5 working days
            of the delivery dates specified on CryoCath purchase orders.

      (b)   CryoCath shall submit purchase orders for Systems to ENDOCARE in
            writing, either by mail, facsimile or e-mail, which shall, at a
            minimum, set forth the product numbers, quantities, requested
            delivery dates, special shipping instructions and shipping addresses
            for all Systems ordered. All orders shall be subject to acceptance
            in accordance with the terms of this Agreement by ENDOCARE. The
            terms and conditions of this Agreement shall govern and supersede
            any additional or contrary terms set forth in CryoCath's purchase
            order or any ENDOCARE or CryoCath acceptance, confirmation, invoice
            or other document unless duly signed by an officer of CryoCath and
            an officer of ENDOCARE and expressly stating and identifying which
            specific additional or contrary terms shall supersede the terms and
            conditions of this Agreement.

      (c)   No accepted purchase order shall be modified or canceled except upon
            the mutual agreement of both parties. Mutually agreed upon change
            orders shall be subject to all provisions of this Agreement, whether
            or not the change order so states. Notwithstanding the foregoing,
            any purchase order may be canceled by CryoCath as to any Systems
            which are not delivered within sixty (60) days of the delivery date
            requested by CryoCath or as otherwise provided for herein, and any
            such cancellation shall not limit or affect any contract remedies
            available to CryoCath with respect thereto. Any such cancellation by
            CryoCath must be by written notice to ENDOCARE, given within fifteen
            (15) business days after such sixtieth (60th) day.

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      (d)   All deliveries of Systems shall be ***. All Systems deliveries shall
            be made by a common carrier specified by CryoCath. In the event that
            no carrier shall have been specified by CryoCath, a common carrier
            may be selected by ENDOCARE.

      (e)   Within the term of this Agreement and subject to the Field of Use
            and within the CryoCath Territories, ENDOCARE shall not make any
            modifications or enhancements of the Systems or any other changes in
            the Specifications for the Systems in the Field of Use without prior
            written approval from CryoCath. If such changes would affect the
            applicable regulatory approvals of the Systems, CryoCath shall not
            be required to purchase such Systems until such time as regulatory
            authorization is received. Endocare shall have the right to make
            changes to the Systems for applications outside of the Field of Use.

      (f)   ENDOCARE shall be responsible for supplying the Systems in a
            finished state appropriate for delivery to the end customer
            including packaging and any necessary sterilization of Systems
            purchased under this Agreement in accordance with the
            Specifications.

      (g)   In addition to the payments specified in Section 2.3 above, upon
            execution of this Agreement, CryoCath will place a stocking order
            with ENDOCARE consisting of *** single probe ENDOCARE Cryo-Consoles
            and *** malleable cryoprobes. CryoCath agrees to take delivery of
            the entire order within the first annual period on the dates
            specified within the CryoCath purchase orders.

      (h)   CryoCath will place an additional purchase order at the beginning of
            the second annual period for *** single probe ENDOCARE Cryo-Consoles
            and *** cryosurgical probes. CryoCath agrees to take delivery of
            that order within the second annual period on the dates specified
            within the CryoCath purchase orders. Product delivery will be
            determined by CryoCath.

      (i)   In the event that CryoCath fails to place the second stocking order
            and/or fails to pay the second license fee payment when due, then
            ENDOCARE has the option of terminating this Agreement. In this case
            the rights and responsibilities following conversion to a
            non-exclusive period as outlined below in Section 5.3 will not
            apply. Notwithstanding termination, CryoCath will have the right to
            service existing customers only using the ENDOCARE product for a
            minimum of 18 months from termination in order to ensure proper
            customer support.

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      (j)   ENDOCARE may refuse to fill any purchase order in the event that
            CryoCath is delinquent in any payment of previous purchase orders or
            milestone payments.

2.10  REPORTS.

      (a)   CryoCath shall use reasonable efforts to report any "adverse
            incidents" (as defined by FDA regulations, Medical Devices Directive
            and national regulations) promptly to ENDOCARE.

2.11  EXPORT/IMPORT APPROVALS.

      (a)   CryoCath shall be responsible for obtaining, at CryoCath's cost and
            expense, all necessary documentation and licenses necessary to
            export product from the U.S. provided that ENDOCARE's manufacturing
            of the Systems remains in the U.S.

      (b)   ENDOCARE shall be responsible for obtaining, at ENDOCARE's cost and
            expense, all export licenses and permits as may be required to
            export the Systems from any country of manufacture other than the
            U.S. into the particular countries within the CryoCath Territories.

      (c)   CryoCath shall be responsible for obtaining, at CryoCath's cost and
            expense, such import licenses and permits as may be required to
            import the Systems into particular countries within the CryoCath
            Territories as selected by CryoCath in accordance with then
            prevailing laws and regulations of such countries. This
            Import/Export approval is separate and distinct from FDA and CE Mark
            approvals as described in section 2.2 (a). All such filings and
            registrations of the Systems shall be made in the name of CryoCath
            whenever feasible in accordance with prevailing laws and regulations
            except as provided for in Section 2.2 (a). ENDOCARE shall exercise
            reasonable cooperation with CryoCath in its efforts to obtain any
            such approvals.

2.12  BUSINESS OVERSIGHT GROUP.

      (a)   The parties agree to establish a business oversight group for
            purposes of planning, reviewing the business, and ensuring smooth
            operations and a mutually beneficial relationship between the
            parties under this Agreement. The group will initially consist of
            two designated individuals from each of ENDOCARE and CryoCath. The
            group will meet as deemed necessary and mutually agreed to, but not
            less than three times during the first annual period. Meetings will
            be held alternately at CryoCath's and ENDOCARE's head offices and
            each party shall bear the expenses for its representatives

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            to attend these meetings. The business oversight group will discuss
            such topics as marketing activities, progress and strategies
            including targets, plans, etc. as well as manufacturing and supply
            issues, future product requirements, new product designs etc.

                                    ARTICLE 3
                      ENDOCARE DEVELOPMENT RESPONSIBILITIES

ENDOCARE will develop Systems at ENDOCARE's sole cost as follows:

3.1   CRYOPROBES.

      (a)   ENDOCARE will develop such cryosurgical probes as CryoCath may
            request from time to time in accordance with sections 3.3, 3.4 and
            3.5 of this Agreement. The first generation probe hereunder will be
            a surgical, disposable, epicardial/endocardial linear cryoablation
            probe that can be used to cure arrhythmias during open chest,
            stopped heart surgery (MV/CABG), with specifications as more
            particularly described in Schedule 1 which shall be subject to being
            finalized by mutual agreement as described in section 3.4(a).

3.2   CRYO-CONSOLES.

      (a)   ENDOCARE will develop a first generation Cryo-Console that will not
            have a display screen or dedicated microprocessor/software and with
            specifications as more particularly described in Schedule 1 which
            shall be subject to being finalized by mutual agreement as described
            in section 3.4(a).

3.3   NEW CRYOPROBES.

      (a)   CryoCath may request that ENDOCARE develop new cryoprobes by, at
            CryoCath's option, placing an order for *** such probes (to be paid
            50% prepaid and 50% upon delivery) or making a cash payment of ***
            (to be paid 50% prepaid and 50% upon delivery). CryoCath is
            responsible for supplying a product requirement document at the time
            of placing an order, which shall be based on a product requirement
            document (MRS) jointly signed by the parties. Any such new *** probe
            order will not be applied to CryoCath's Minimum Purchase
            Requirements hereunder. However, in the event that CryoCath has
            selected the *** cash payment option, all subsequent orders for such
            new probes will apply to the Minimum Purchase Requirements. CryoCath
            may request two new cryoprobe designs in addition to the malleable
            cryoprobe under the terms of this

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                                                                              14

            Section 3.3. The terms for the supply of additional cryoprobe
            designs requested beyond the malleable and the *** additional
            designs referenced above will be negotiated and agreed to by both
            parties.

3.4   MUTUAL AGREEMENT TO DESIGN OF SYSTEMS.

      (a)   All probe and Cryo-Console designs will be mutually agreed upon by
            both parties prior to finalization and market introduction. Basic
            performance and design requirements for the second generation
            malleable and deflectable tip probe are described in Schedule 1 and
            shall be subject to being finalized by mutual agreement. All other
            new design requirements will be supplied to ENDOCARE when CryoCath
            places a formal new product request.

      (b)   Except for the products described in Schedule 2, ENDOCARE reserves
            the right to make pricing adjustments based on any new product
            design specifications which must be mutually agreed to in writing
            prior to the development of such new products by ENDOCARE.

3.5   TIMELINES FOR SYSTEM DEVELOPMENTS.

      (a)   ENDOCARE must deliver the new malleable cryoprobe within 6 months of
            the execution of this Agreement and ENDOCARE must deliver the new
            Cryo-Console with a limited probe reuse function within 9 months of
            the execution of this Agreement. Functional prototypes for animal
            studies will be made available for CryoCath to purchase at
            ENDOCARE's cost as soon as is reasonable prior to clinical product
            availability.

      (b)   ENDOCARE will provide CryoCath with a System including a second
            generation simplified Cryo-Console incorporating a means of limiting
            probe reuse as described herein for market sales (i.e. animal trials
            completed and all required regulatory documentation in place for the
            U.S. and the European Community) within 9 months of the Effective
            Date of this Agreement.

      (c)   If either of the product availability commitments outlined in
            Sections 3.5 (a) or (b) are late and subject to the cure period
            allowed for in section 3.5 (e),

                                      ***
                                      ***
                                      ***

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                                                                              15

      (d)   ENDOCARE must deliver the new deflecting tip probe design for market
            sale within 12 months of the purchase order payment as outlined in
            Section 3.3. The timeline for delivery of the third probe design
            that CryoCath may require shall be established by mutual agreement.

      (e)   If ENDOCARE does not deliver new products within the specified time
            limit described in Section 3.5 (a), (b) or (d), then ENDOCARE will
            have 90 days after the time period to rectify the problem and
            deliver the product for market sale. ENDOCARE must submit plans
            showing a good faith effort to deliver the product in a timely
            manner. During this 90 day period all CryoCath minimum sales
            commitments will be suspended and delayed until such time as the new
            product becomes available. If after 90 days the product is still not
            available for sale, then CryoCath will have the option of either
            terminating this Agreement and obtaining a full refund of all monies
            paid to ENDOCARE including but not limited to the "new probe" cash
            payment or pre-payment, or converting the Agreement to non-exclusive
            as per the terms of Article 5 and meeting all milestone payments as
            specified in Section 2.3 up to the point of conversion to
            non-exclusive status. Alternatively, CryoCath may continue to wait
            for the new product and all minimum sales commitments will continue
            to be suspended and delayed until such time as the new product
            becomes available.

      (f)   ENDOCARE will develop the probes, at ENDOCARE's cost, including
            safety validation testing and performance testing in animal models
            sufficient to satisfy the requirements for human use as determined
            by the physician(s) that ENDOCARE selects to assist in the product
            development process provided that CryoCath has accepted the probe
            designs as required by Section 3.4.

                                    ARTICLE 4
                              TERM AND TERMINATION

4.1   INITIAL TERM.

      (a)   The initial term (the "Initial Term") for CryoCath's rights and
            obligations as the sole and exclusive worldwide market access
            partner with rights to market, sell and distribute the Systems in
            the Field of Use in the CryoCath Territories shall commence on the
            Effective Date of this Agreement and end five (5) years thereafter.

<PAGE>
                                                                              16

4.2   RENEWAL TERM; MINIMUM PURCHASE REQUIREMENTS; CONTINUOUS SUPPLY.

      (a)   The Initial Term of CryoCath's rights and obligations as sole and
            exclusive worldwide market access partner with rights to market,
            sell and distribute the Systems in the Field of Use in the CryoCath
            Territories may be renewed for up to (a) two (2) additional three
            (3) year periods (each a "Renewal Term") by mutual agreement,
            provided CryoCath and ENDOCARE have met or exceeded the Minimum
            Purchase Requirements set forth on Schedule 3 and product
            availability requirements as defined in Article 3.5, respectively,
            and thereafter to be established by the parties for the CryoCath
            Territories for the then current Renewal Term and provided the
            parties mutually agree to pricing and Minimum Purchase Requirements
            for the Renewal Term. The parties agree to commence good faith
            negotiations regarding renewal by not later than 12 months prior to
            the expiry of the Initial Term or Renewal Term and to conclude such
            negotiations by not later than 6 months prior to each such expiry.
            In the event that the terms for a Renewal Term cannot be agreed upon
            notwithstanding the reasonable efforts of both parties, the
            Agreement shall be converted into a non-exclusive license and the
            rights and responsibilities of Article 4.3 shall come into effect.

      (b)   In determining whether CryoCath has met its Minimum Purchase
            Requirements hereunder, CryoCath will be entitled to a reduction in
            the Minimum Purchase Requirements for up to two (2) consecutive
            quarters for the amount that CryoCath has exceeded its Minimum
            Purchase Requirements in the current quarter. CryoCath will be
            responsible to meet the Minimum Purchase Requirements for each
            annual period as specified in Schedule 3 without the benefit of
            carryover.

      (c)   In the event that ENDOCARE is unable or unwilling to continue to
            supply product at any time during the Initial Term, or any Renewal
            Term or non-exclusive period, then ENDOCARE must provide written
            notice to CryoCath that it wishes to stop supplying product to
            CryoCath effective twelve (12) months from the date such notice is
            received by CryoCath. In this case, ENDOCARE shall continue to
            supply CryoCath with all of CryoCath's product needs for the twelve
            (12) month notice period in accordance with the pricing terms set
            forth in this Agreement. During this twelve (12) month period,
            CryoCath will be responsible for maintaining quarterly purchases
            from ENDOCARE calculated as one-fourth the total purchases of the
            twelve months prior to the notice. However, during the twelve (12)
            month period, or any portion thereof, the minimum quarterly
            purchases may be reduced if CryoCath is able to substantiate, in
            writing, that it no longer sells products to a customer who
            purchased products prior to the twelve (12) month notice period. In
            the event that ENDOCARE

<PAGE>
                                                                              17

            fails to supply CryoCath at any time during the said twelve (12)
            month notice period, ENDOCARE shall upon written notice from
            CryoCath provide CryoCath or a CryoCath-designated third party with
            a royalty-free license to manufacture the ENDOCARE Systems for the
            Field of Use for the remainder of the twelve (12) month notice
            period. This transfer will include ENDOCARE's full and immediate
            cooperation in the transfer of all required know-how, manufacturing
            procedures, specifications and such other information as may be
            required to manufacture the Systems. Under no circumstances may
            CryoCath designate a third party to manufacture the Systems who is a
            direct competitor of ENDOCARE in the use of cryotherapy.

4.3   CONVERSION TO NON-EXCLUSIVE FOR FAILURE TO MEET MINIMUM PURCHASE
      REQUIREMENTS OR FAILURE TO MEET PRODUCT AVAILABILITY

      (a)   Subject to Article 7 thereof, following the first two annual
            periods, if CryoCath fails to meet the quarterly Minimum Purchase
            Requirements for the CryoCath Territories as set out in Schedule 3
            for *** , ENDOCARE shall have the right to notify CryoCath that it
            will convert CryoCath's future rights and obligations as the
            exclusive worldwide market access partner for the CryoCath
            Territories to a non-exclusive basis for a period of *** from the
            date of conversion.

      (b)   CryoCath shall have *** following written notice from ENDOCARE to
            convert the Agreement to non-exclusive due to breach including
            failure to meet Minimum Purchase Requirements, in which to cure such
            default by making up the total deficiency together with reasonable
            evidence of a plan that will cure any such failure to meet the
            Minimum Purchase Requirements in the future.

      (c)                             ***
                                      ***
                                      ***.

      (d)   In the event that the aggregate difference amount is not purchased
            or the fee not paid as described above, ENDOCARE will have the
            option of either converting to non-exclusive status in accordance
            with the terms set forth herein or continuing to wait for CryoCath
            to rectify the cumulated missed Minimum Purchase Requirements. In
            the latter case, ENDOCARE will have no further obligation to supply
            newly developed products hereunder for as long as the default
            remains uncured.

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                                                                              18

      (e)   During any non-exclusive period, CryoCath will maintain minimum
            quarterly product purchases from ENDOCARE equal to the greater of
            *** or *** .

      (f)                              ***
                                       ***
                                       ***
                                       ***
                                       ***.

4.4   CRYOCATH'S TERMINATION FOR ENDOCARE BREACH.

      (a)   Subject to Article 6 hereof, if ENDOCARE breaches any of its
            material obligations under this Agreement including but not limited
            to ENDOCARE's development responsibilities under Article 3, then
            CryoCath shall be entitled to terminate CryoCath's rights and
            obligations under this Agreement without prejudice to all other
            rights and recourses for damages or otherwise. CryoCath shall give
            ENDOCARE written notice of any such intent to terminate, and
            ENDOCARE shall have ninety (90) days in which to cure such material
            breach. ENDOCARE hereby acknowledges CryoCath's right to continue to
            sell Systems purchased from ENDOCARE to any person or entity in the
            CryoCath Territories for eighteen (18) months or the remainder of
            any non-exclusive period, whichever is greater.

4.5   ENDOCARE'S TERMINATION FOR CRYOCATH BREACH.

      (a)   Subject to Article 6 hereof and except as otherwise provided in
            Article 4.3, if CryoCath breaches any of its material obligations
            under this Agreement, then ENDOCARE shall be entitled to terminate
            CryoCath's rights and obligations under this Agreement without
            prejudice to all other rights and recourses for damages or
            otherwise. ENDOCARE shall give CryoCath written notice of any such
            intent to terminate, specifying whether such termination will apply
            to CryoCath's rights and obligations, and CryoCath shall have ninety
            (90) days in which to cure such material breach.

4.6   RIGHTS AND OBLIGATIONS ON TERMINATION.

      (a)   In the event of termination of all or a portion of this Agreement
            for any reason, the parties shall have the following rights and
            obligations: In the event of the termination of CryoCath's
            distribution rights with respect to

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                                                                              19

            all of the CryoCath Territories in accordance with Article 4.4 or
            Article 4.5,

            (i)   CryoCath shall be permitted to fill any outstanding orders
                  from customers made prior to the date of termination, and

            (ii)  CryoCath and ENDOCARE shall cooperate to ensure continued
                  service and support to customers in the CryoCath Territories
                  who purchased Systems from CryoCath.

                                    ARTICLE 5
                                 INDEMNIFICATION

5.1   ENDOCARE'S LIABILITY.

      (a)   ENDOCARE shall, at ENDOCARE's sole cost and expense, indemnify,
            defend and hold CryoCath, its officers, directors, employees, agents
            and consultants harmless from and against any judgment or settlement
            and associated litigation and/or settlement costs (including
            reasonable attorney's fees and costs) that arise out the products'
            failure to meet the warranty as described in Subsection 2.5(d), for
            any claims based on products liability theory against the products.
            CryoCath shall provide ENDOCARE with written notification of any
            claim subject to indemnification pursuant to this Section 5.1 and of
            any associated court filings promptly after CryoCath first learns of
            them. CryoCath shall provide ENDOCARE with such assistance and
            cooperation as ENDOCARE may reasonably request from time to time in
            connection with the defense thereof. CryoCath will use reasonable
            efforts to mitigate all such claims, losses, damages, expense or
            liability after receipt of notice thereof. Without restricting the
            generality of the foregoing, ENDOCARE indemnification shall extend
            to (i) any breach of representation, warranty, covenant or agreement
            on the part of ENDOCARE under this Agreement, (ii) total or partial
            Systems recalls, (iii) alleged defects in materials, workmanship,
            product performance or design of the Systems, but in any event
            excluding matters for which CryoCath is responsible under Article
            5.2 below, or (iv) any infringement claims by third parties of
            Intellectual Property related to the System, but not including the
            methods applied in the use of the Systems, nor on any future
            products requested by CryoCath, nor any products jointly developed.
            ENDOCARE shall maintain product liability insurance in such amounts
            as is advisable pursuant to ordinary good business practice for a
            similar company in a similar type of business, and shall provide
            CryoCath with evidence of this coverage. CryoCath will use
            reasonable efforts to mitigate all such claims, losses, damages,
            expense or liability after receipt of notice thereof.

<PAGE>
                                                                              20

5.2   CRYOCATH'S LIABILITY.

      (a)   CryoCath shall, at CryoCath's sole cost and expense, indemnify,
            defend and hold ENDOCARE and its officers, directors, employees,
            agents and consultants harmless from and against any judgment or
            settlement and associated litigation and/or settlement costs
            (including reasonable attorney's fees and costs) that arise out of
            the negligent or intentionally tortuous conduct of CryoCath's
            business, or CryoCath's use or sale of products delivered to it by
            ENDOCARE or any representations made by CryoCath regarding proposed
            or recommended methods of use for the Products, or any claim of
            patent infringement related to CryoCath's method of use of the
            products delivered to it by ENDOCARE. ENDOCARE shall provide
            CryoCath with written notification of any claim subject to
            indemnification pursuant to this Section 5.2 and of any associated
            court filings promptly after ENDOCARE first learns of them. ENDOCARE
            shall provide CryoCath with such assistance and cooperation as
            CryoCath may reasonably request from time to time in connection with
            the defense thereof. ENDOCARE will use reasonable efforts to
            mitigate all such claims, losses, damages, expense or liability
            after receipt of notice thereof.

5.3   THIRD PARTY CLAIMS.

      (a)   If a claim by a third party is made against any indemnified party,
            such indemnified party shall promptly notify the indemnifying party
            of such claim, provided however that failure to give timely notice
            shall not affect the rights of the indemnified party so long as the
            failure to give timely notice does not materially adversely affect
            the indemnifying party's ability to defend such claim against a
            third party. The indemnifying party shall have the sole right to
            manage, settle and defend such claim, at the expense of the
            indemnifying party and with counsel chosen by the indemnifying
            party. The indemnified party shall have the right to participate in
            such action, at its own expense and with counsel of its own choice.
            The indemnified party shall provide reasonable cooperation and
            assistance to the indemnifying party, at the expense of the
            indemnifying party. The indemnified party shall not enter into any
            agreement with respect to such claim or threatened claim without
            receipt of prior written approval from the indemnifying party.

      (b)   In the event of a third party claim of Intellectual Property
            infringement with respect to the single-probe Cryo-Console or
            malleable cryoprobe where ENDOCARE indemnifies CryoCath, ENDOCARE
            will (1) make reasonable efforts to obtain a license which can be
            used by CryoCath or, (2) make reasoanble efforts to modify the
            Systems to make them noninfringing.

<PAGE>
                                                                              21

5.4   COOPERATION AS TO INDEMNIFIED LIABILITY.

      (a)   Each party hereto shall cooperate fully with the other parties with
            respect to access to books, records or other documentation within
            such party's control, if deemed reasonably necessary or appropriate
            by any party in the defense of any claim that may give rise to
            indemnification hereunder.

                                    ARTICLE 6
                                  FORCE MAJEURE

6.1   FORCE MAJEURE.

      (a)   "Force Majeure" shall mean any event or condition, not existing as
            of the date of signature of this Agreement, not reasonably
            foreseeable as of such date and not reasonably within the control of
            either party, which prevents in whole or in material part the
            performance by one of the parties of its obligations hereunder, such
            as an act of God, act of government, war or related actions, civil
            insurrection, riot, sabotage, epidemic, fire, flood, windstorm,
            earthquake and similar events.

6.2   NOTICE.

      (a)   Upon giving notice to the other party, a party affected by an event
            of Force Majeure shall be released without any liability on its part
            from the performance of its obligations under this Agreement, except
            for the obligation to pay any amounts due and owing hereunder in
            respect of products sold and delivered, but only to the extent and
            only for the period that its performance of such obligations is
            prevented by the event of Force Majeure.

6.3   SUSPENSION OF PERFORMANCE.

      (a)   During the period that the performance by one of the parties of its
            obligations under this Agreement has been suspended by reason of an
            event of Force Majeure, the other party may likewise suspend the
            performance of all or part of its obligations (other than payment
            obligations) hereunder to the extent that such suspension is
            commercially reasonable.

<PAGE>
                                                                              22

                                   ARTICLE 7
                              INTELLECTUAL PROPERTY

7.1   TRADEMARK LICENSE.

      (a)   ENDOCARE grants CryoCath a non-transferable, royalty-free and
            non-exclusive license to use ENDOCARE's trademarks, service marks,
            icons or logos ("ENDOCARE Marks") provided to CryoCath by ENDOCARE,
            only in the CryoCath Territories and only in connection with the
            obtaining of regulatory approval of the Systems and the marketing
            and promotion of Products to end-users. The trademark license
            granted to CryoCath herein is only sublicensable by CryoCath to
            distributors of the Systems. CryoCath shall submit to ENDOCARE in
            writing for its prior written approval, which approval may not be
            unreasonably withheld or delayed, one (1) sample of each Product
            brochure or other marketing material on which any ENDOCARE Mark is
            proposed to be used. ENDOCARE will provide CryoCath written notice
            of its approval or disapproval within fifteen (15) days after
            receiving such request; provided, however, that if ENDOCARE does not
            disapprove CryoCath's request within such fifteen (15) day period,
            the proposed use shall be deemed approved. ENDOCARE reserves the
            right to change, modify or replace any ENDOCARE Mark at any time,
            and CryoCath agrees to comply with such changes at its sole cost.
            Except for the permitted uses as described in Section 4.6, CryoCath
            will cease using any materials containing any ENDOCARE Mark
            immediately upon termination of the Agreement, or at any time
            sooner, upon written request by ENDOCARE. CryoCath will not alter,
            modify or change any ENDOCARE Mark, or use it in combination with
            any other words or symbols, without the prior written authorization
            of ENDOCARE. CryoCath agrees that the presentation and image of
            ENDOCARE Marks will be uniform and consistent with respect to the
            Products associated with such ENDOCARE Marks. The use of ENDOCARE
            Marks by CryoCath shall inure to the sole benefit of ENDOCARE.
            CryoCath agrees not to apply for registration of ENDOCARE Marks (or
            any mark confusingly similar thereto) anywhere in the world.

7.2   OWNERSHIP.

      (a)   Subject to all the terms and conditions of this Agreement, ENDOCARE
            grants CryoCath a non-transferable, non-sub-licensable, and
            royalty-free license to use any technology, know how, trade secrets,
            and other propriety information of ENDOCARE that ENDOCARE may share
            with CryoCath under this Agreement (including, without limitation,
            the specifications and all Confidential Information shared with
            CryoCath in an effort to obtain regulatory approval of the Systems),
            only in connection with the obtaining of regulatory approval of the
            Systems and the

<PAGE>
                                                                              23

            marketing and promotion of Systems to end-users in the CryoCath
            Territories. All such technology, however, is and shall remain the
            sole property of ENDOCARE and shall be subject to the
            confidentiality provisions of Schedule 4. Nothing in this license or
            elsewhere in this Agreement shall be construed to grant to CryoCath
            any rights whatsoever in ENDOCARE's technology or intellectual
            property other than as delineated in this license

      (b)   ENDOCARE represents and warrants to CryoCath that as of the
            Effective Date: It has the right to grant the rights and licenses
            granted to CryoCath in this Agreement and the execution and
            performance of this Agreement by ENDOCARE and the transactions
            contemplated herein do not conflict with any agreement to which
            ENDOCARE is a party or by which it is bound;

      (c)   ENDOCARE represents and warrants to CryoCath that as of the
            Effective Date: It has sufficient right, title and interest to the
            the Intellectual Property necessary for the manufacture, use or sale
            of the Systems as contemplated herein;

      (d)   As of the Effective Date of this Agreement, ENDOCARE warrants to
            CryoCath and to CryoCath's customers that Systems sold by ENDOCARE
            do not infringe any patents, trade secrets, trademarks or other
            intellectual property rights of any third party;

      (e)   ENDOCARE has no knowledge of any claim by a third person that
            manufacture, use or sale of the Systems as contemplated in this
            Agreement infringes the patent, copyright, trademarks, trade secret
            or other intellectual property rights of any third person.

      (f)   CryoCath will acquire good and marketable title to all Systems and
            product free and clear of all liens and other charges.

7.3   IMPROVEMENTS AND ENHANCEMENTS TO THE SYSTEMS.

      (a)   During the term of this Agreement, each party shall promptly inform
            and make available to the other any material invention, improvement,
            upgrading or modification relating to the Systems or ENDOCARE's
            Intellectual Property relating to the Systems at no cost to the
            other party.

7.4   OTHER INTELLECTUAL PROPERTY.

      (a)   All Intellectual Property owned by either party prior to executing
            this Agreement remains solely owned by that party and any
            Intellectual Property jointly developed within this Agreement will
            be jointly owned as a co-inventor as that term is used under the
            applicable patent laws with all

<PAGE>
                                                                              24

            the rights, title and interests associated with intellectual
            property development and ownership.

                                    ARTICLE 8
                                  MISCELLANEOUS

8.1   NON-DISCLOSURE.

      (a)   The parties to this Agreement will abide by all terms contained in
            the Mutual Non-disclosure Agreement that is attached as Schedule 4.

8.2   RELATIONSHIP.

      (a)   This Agreement does not make either party the employee, agent or
            legal representative of the other for any purpose whatsoever.
            Neither party is granted any right or authority to assume or to
            create any obligation or responsibility, express or implied, on
            behalf of or in the name of the other party. In fulfilling its
            obligations pursuant to this Agreement, each party shall be acting
            as an independent contractor.

8.3   ASSIGNMENT.

      (a)   Neither ENDOCARE nor CryoCath shall assign its rights or obligations
            under this Agreement without prior written consent of the other
            party hereto, for any reason including, but not limited to, the
            transfer or sale of all or substantially all of the party's assets
            or equity, or in the event of a merger or consolidation or change in
            control or similar transaction.

      (b)   In the event of a change of control of either party, the following
            options are available:

            (i)   The parties may mutually agree, in writing, to honor the terms
                  of this Agreement.

            (ii)  The parties may choose to renegotiate this Agreement.

            (iii)                      ***
                                       ***
                                       ***
                                       ***.

8.4   COMPLETE AGREEMENT.

      (a)   This Agreement and the Schedules hereto constitute the entire
            agreement between the parties hereto with respect to the subject
            matter hereof and

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                                                                              25

            supersede all prior agreements whether written or oral relating
            hereto. This Agreement supersedes all written correspondence,
            including but not limited to all terms sheets, between ENDOCARE and
            CryoCath negotiating the terms related to the subject matter hereof.

8.5   GOVERNING LAW AND DISPUTE RESOLUTION.

      (a)   In the event of any dispute with respect to the subject matter of
            this Agreement which remains unresolved for a period of at least 90
            days despite the parties' good faith efforts to negotiate a
            resolution thereof and in particular the elevation of the matter to
            the parties respective CEO's, the matter shall be submitted by
            either party to final and binding commercial arbitration pursuant to
            the rules of the American Arbitration Association. The arbitrator
            shall be an individual mutually agreed to by the parties, or if the
            parties are unable to agree, selected by the AAA, who is
            knowledgeable and experienced in the high technology medical device
            industry. The venue for any such arbitration shall be Boston,
            Massachusetts. This Agreement shall be governed by and interpreted
            in accordance with the laws of the Commonwealth of Massachusetts,
            including all matters of construction, validity, performance and
            enforcement, without giving effect to principles of conflict of
            laws.

8.6   SURVIVAL.

      (a)   All of the representations, warranties and covenants made in this
            Agreement, and all terms and provisions hereof intended to be
            observed and performed by the parties after the termination hereof,
            shall survive such termination and continue thereafter in full force
            and effect.

8.7   WAIVER, DISCHARGE, AMENDMENT, ETC.

      (a)   The failure of any party hereto to enforce at any time any of the
            provisions of this Agreement shall in no way be construed to be a
            waiver of any such provision, nor in any way to affect the validity
            of this Agreement or any part thereof or the right of the party
            thereafter to enforce each and every such provision. No waiver of
            any breach of this Agreement shall be held to be a waiver of any
            other or subsequent breach. Any amendment to this Agreement shall be
            in writing and signed by the parties hereto.

8.8   COUNTERPARTS.

      (a)   This Agreement may be executed in any number of counterparts, each
            of which shall be deemed as original and all of which together shall
            constitute one instrument.

<PAGE>
                                                                              26

8.9   TITLES AND HEADINGS; CONSTRUCTION.

      (a)   The titles and headings to Articles and Sections herein are inserted
            for the convenience of reference only and are not intended to be a
            part of or to affect the meaning or interpretation of this
            Agreement. This Agreement shall be construed without regard to any
            presumption or other rule requiring construction hereof against the
            party causing this Agreement to be drafted.

8.10  BENEFIT.

      (a)   Nothing in this Agreement, expressed or implied, is intended to
            confer on any person other than the parties to this Agreement or
            their respective successors or assigns, any rights, remedies,
            obligations or liabilities under or by reason of this Agreement.

8.11  NOTICES.

      (a)   All notices or other communications to a party required or permitted
            hereunder shall be deemed given if in writing and delivered
            personally or sent by telecopy (with confirmation of transmission)
            or certified mail (return receipt requested) to such party at the
            following addresses (or at such other addresses as shall be
            specified by like notice):

   If to CryoCath, to:        CryoCath Technologies Inc.
                              16771 Chemin Ste-Marie
                              Kirkland, Quebec, Canada H9H 5H3
                              ***

   with a copy to:            CryoCath Technologies Inc.
                              16771 Chemin Ste-Marie
                              Kirkland, Quebec, Canada H9H 5H3
                              ***

   and if to ENDOCARE, to:    ENDOCARE Inc.
                              7 Studebaker
                              Irvine, California 92618
                              ***

   with a copy to:            ENDOCARE Inc.
                              7 Studebaker
                              Irvine, California 92618
                              ***

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                                                                              27

            CryoCath or ENDOCARE may change their respective above-specified
            recipient and/or mailing address by notice to the other party given
            in the manner herein prescribed. All notices shall be deemed given
            on the day when actually delivered as provided above (if delivered
            personally or by telecopy) or on the day shown on the return receipt
            (if delivered by mail).

8.12  ILLEGALITY.

      (a)   In case any provision of this Agreement shall be invalid, illegal or
            unenforceable, the validity, legality and enforceability of the
            remaining provisions shall not in any way be affected or impaired
            thereby.

8.13  PUBLIC ANNOUNCEMENT.

      (a)   Each of the parties to this Agreement hereby agrees with the other
            party hereto that, except as may be required to comply with the
            requirements of applicable law or any exchange upon which such
            party's capital stock is listed or traded, no press release or
            similar public announcement or communication will be made or caused
            to be made concerning the execution or performance of this Agreement
            unless specifically approved in advance by CryoCath and ENDOCARE.
            The foregoing shall not restrict either party's communications with
            employees, customers or private investors.

<PAGE>
                                                                              28

8.14    EXECUTION OF FURTHER DOCUMENTS.

      (a)   Each party agrees to execute and deliver without further
            consideration any further applications, licenses, assignments or
            other documents, and to perform such other lawful acts as the other
            party may reasonably require to fully secure and/or evidence the
            rights or interests herein.

IN WITNESS WHEREOF, each of the parties has caused this Agreement to be executed
in the manner appropriate to each, as of the date first above written.

ENDOCARE, INC.                          CRYOCATH TECHNOLOGIES INC.

/s/ Paul Mikus                          /s/ Steven G. Arless
------------------------------------    -----------------------------------
President/CEO                           President/CEO

ATTACHMENTS:

     Schedule 1 - Product Development and Specifications

     Schedule 2 - Pricing

     Schedule 3 - Minimum Purchase Requirements

     Schedule 4 - Mutual Nondisclosure Agreement

<PAGE>
                                                                              29

                                   SCHEDULE 1

                     PRODUCT DEVELOPMENT AND SPECIFICATIONS
 [THE FOLLOWING ARE INITIAL SPECIFICATIONS BASED ON CURRENT INFORMATION AND ARE
                     SUBJECT TO CHANGE BY MUTUAL AGREEMENT]

First Generation Stopped Heart Epicardial/Endocardial MV/CABG Malleable Device

An open chest (intraoperative), disposable, epicardial/endocardial linear
cryoablation probe that can be used to treat atrial fibrillation (AF) during
open chest surgery, stopped heart surgery (MV/CABG).

                                       ***
                                       ***
                                       ***

----------
*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

<PAGE>
                                                                              30

                                   SCHEDULE 2

                                     PRICING

The transfer price for malleable cryoprobes and single cryoprobe Cryo-Consoles
will be as follows:

                                       ***
                                       ***
                                       ***

----------
*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

<PAGE>
                                                                              31

                                   SCHEDULE 3

                          MINIMUM PURCHASE REQUIREMENTS

MINIMUM PURCHASE REQUIREMENTS

CryoCath will agree to maintain the quarterly minimum purchases from Endocare as
shown in the following schedule:

                                       ***
                                       ***
                                       ***

----------
*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

<PAGE>
                                                                              32

                                   SCHEDULE 4

                         MUTUAL NONDISCLOSURE AGREEMENT

This Mutual Nondisclosure Agreement (the "Agreement") is entered into effective
as of the 7th day of September 2001 by and between ENDOCARE, INC., a Delaware
corporation, and CryoCath Technologies Inc, a Quebec (Canada) corporation. Each
undersigned party (the "Receiving Party") understands that the other party (the
"Disclosing Party") has disclosed or may disclose Confidential Information. The
purpose of this Agreement is to prevent the unauthorized disclosure or use of
Confidential Information.

For purposes of this Agreement, "Confidential Information" shall mean any
information regarding the Disclosing Party (and its business or products),
including the terms of the Exclusive Market Access and Supply Agreement with
Effective Date of September 21, 2001, which is disclosed to the Receiving Party
in connection with any potential or established business relationship or
agreement between the Disclosing Party and the Receiving Party, which has actual
or potential economic value to the Disclosing Party and which is not generally
known to the public at the time it is disclosed to the Receiving Party. Such
Confidential Information shall be in writing and marked confidential, or if
communicated verbally shall be reduced to writing by the Disclosing Party and
marked confidential and sent to the Receiving Party within thirty (30) days of
the verbal communication, and may include, but shall not be limited to, trade
secrets, know-how, negative know-how, formulas, patterns, compilations,
programs, devices, methods, techniques, processes, inventions, source codes,
diagrams, marketing and pricing information, business strategies and information
regarding customers and suppliers.

In consideration of the Disclosing Party's disclosure of Confidential
Information to and other relationships with the Receiving Party, the Receiving
Party hereby agrees as follows:

1.    The Receiving Party shall hold and maintain all Confidential Information
      in strictest confidence and in trust for the sole and exclusive benefit of
      the Disclosing Party.

2.    The Receiving Party shall not, without the prior written approval of the
      Disclosing Party, use for its own benefit, publish or otherwise disclose
      to others, or permit the use by others for their benefit or to the
      detriment of the Disclosing Party, any of the Confidential Information. In
      addition, the Receiving Party shall not, without the prior written
      approval of the Disclosing Party, reverse engineer, decompose or otherwise
      analyze the contents or components of products or materials it receives
      from the Disclosing Party to acquire information that would be
      Confidential Information if then disclosed directly by the Disclosing
      Party.

3.    The Receiving Party shall carefully restrict access to the Confidential
      Information to those of its officers, directors and employees who clearly
      need such access in order to participate on behalf of the Receiving Party
      in the analysis, negotiation or carrying out of a business relationship or
      agreement with the Disclosing Party. The Receiving Party further warrants
      and represents that it will advise each of the persons to whom it provides
      access to any of

<PAGE>
                                                                              33

      the Confidential Information pursuant to the foregoing sentence that such
      persons are strictly prohibited from making any use, publishing or
      otherwise disclosing to others, or permitting others to use for their
      benefit or to the detriment of the Disclosing Party, any of the
      Confidential Information.

4.    The Confidential Information will not be used in any way against the
      interests of the Disclosing Party's interests, including, to file any
      patent application relating to the Confidential Information except in the
      name of or assigned to the Disclosing Party, to provide any reexamination
      or any interference with any patent application which has been filed or
      will be filed by the Disclosing Party relating to the Confidential
      Information, and will not be used to amend any claim in any pending patent
      application to expand the claim to read on, cover, or dominate any
      invention (whether or not patentable) disclosed in the Confidential
      Information

5.    The Receiving Party shall take all necessary action to protect the
      confidentiality of the Confidential Information, except for its disclosure
      pursuant to paragraph 3 above, and hereby agrees to indemnify the
      Disclosing Party against any and all losses, damages, claims, expenses or
      liabilities incurred or suffered by the Disclosing Party as a result of
      the Receiving Party's breach of this Agreement.

6.    The Receiving Party understands and acknowledges that any disclosure or
      misappropriation of any of the Confidential Information in violation of
      this Agreement may cause the Disclosing Party irreparable harm, the amount
      of which may be difficult to ascertain. The Receiving Party therefore
      agrees that the Disclosing Party shall have the right to apply to a court
      of competent jurisdiction for an order restraining any such further
      disclosure or misappropriation and for such other relief as the Disclosing
      Party shall deem appropriate. Such right of the Disclosing Party is to be
      in addition to the remedies otherwise available to the Disclosing Party at
      law or in equity.

7.    Disclosing Party and Receiving Party agree that the obligations of
      confidentiality and nonuse imposed hereunder in Paragraphs 1 and 2 of this
      Agreement shall apply only to Proprietary Information for a period of five
      (5) years following the disclosure date thereof. It is further agreed that
      the obligations of confidentiality and nonuse imposed in Paragraphs 1 and
      2 of this Agreement will not apply to information to the extent of:

      a.)   information which is now or becomes (through no improper action or
            inaction by Receiving Party part of the public domain;

or

      b.)   information already known to Receiving Party at the time of
            disclosure;

or

      c.)   information that was rightfully disclosed to Receiving Party by a
            third party without restriction;

or

<PAGE>
                                                                              34

      d.)   information which can be shown by clear and convincing written
            evidence to have been independently developed by Receiving Party
            without use of any Propriety Information or by employees of
            Receiving Party who have had no access to such information;

or

      e.)   information that the Receiving Party is required by law or court
            order to disclose, provided Receiving Party so notifies Disclosing
            Party in writing as soon as practicable, uses diligent efforts to
            limit disclosure and to obtain confidential treatment or a
            protective order and has allowed Disclosing Party to participate in
            the proceeding.

PROVIDED, however, that nothing in this paragraph shall be construed as
granting, in any way, any type of assignment or license under any patent,
trademark, trade secret or copyright of Disclosing Party or any other entity.

8.    The Receiving Party shall return to the Disclosing Party any and all
      records, notes and other written, printed or tangible materials pertaining
      to the Confidential Information immediately on the written request of the
      Disclosing Party.

9.    This Agreement and the Receiving Party's obligations hereunder shall be
      binding on the representatives, assigns and successors of the Receiving
      Party and shall inure to the benefit of the Disclosing Party's assigns and
      successors.

10.   This Agreement shall be governed by and construed in accordance with the
      laws of the Commonwealth of Massachusetts, excluding its conflict of laws
      rules. Any action or proceeding to enforce or interpret the provisions of
      this Agreement may be brought by either party to final and binding
      commercial arbitration pursuant to the rules of the American Arbitration
      Association in Boston, Massachusetts.

11.   If any action at law or in equity is brought to final and binding
      commercial arbitration to enforce or interpret the provisions of this
      Agreement, the prevailing party in such action shall be entitled to
      reasonable attorneys' fees.

12.   This Agreement constitutes the sole understanding of the parties about the
      subject matter hereof and may not be amended or modified except in writing
      signed by each of the parties to the agreement.

13.   This Agreement may be executed in one or more counterparts, each of which
      shall be a valid original agreement.

14.   If any provision of this Agreement or its application to any person or
      circumstance is held invalid or unenforceable to any extent, the remainder
      of this Agreement and its other application to any person or circumstance
      shall not be affected and shall be enforceable to the full extent
      permitted by law.

<PAGE>
                                                                              35

15.   No waiver of any provision of this Agreement will be deemed to be or will
      constitute a waiver of any other provision or other application of the
      same provision, whether or not similar, nor will any waiver constitute a
      continuing waiver.

ENDOCARE, INC.                          CryoCath Technologies Inc.

By: /s/ Paul Mikus                      By: /s/ Steven G. Arless
    --------------------------------        --------------------------------
Signature                               Signature

Paul Mikus                              Steven G. Arless
--------------------------------        --------------------------------
Printed Name                            Printed Name

    CEO                                     President & CEO
------------------------------------    ------------------------------------
Title                                   Title<PAGE>
                                                                   EXHIBIT 10.46

                             DISTRIBUTION AGREEMENT

      This Distribution Agreement ("Agreement") is dated as of September 25,
2001 (the "Effective Date"), by and between Qualigen, Inc., a Delaware
corporation having its principal place of business at 2042 Corte del Nogal,
Carlsbad, CA 92009 ("Qualigen"), and Endocare, Inc., a Delaware corporation
having its principle place of business at 7 Studebaker, Irvine, CA 92618
("Endocare").

                                   BACKGROUND

      WHEREAS, Qualigen develops, manufactures, markets and sells the
FastPack(R) System, an immunoassay testing system for physician office
laboratory use, consisting of the FastPack Analyzer and FastPack disposable test
packs for performing a menu of immunoassay tests including, or planned to
include but not limited to, Total PSA, Free PSA and Testosterone (said analyzer
and disposable test packs hereinafter jointly referred to as the "Products");
and

      WHEREAS, Endocare desires to market and sell the Products in the United
States of America; and

      WHEREAS, Qualigen desires to grant Endocare, and Endocare desires to
obtain from Qualigen, non-exclusive distribution rights to market and sell the
Products to urology practices (the "Authorized Customers") in the United States
(hereinafter the "Territory") upon the terms and conditions set forth in this
Agreement.

      NOW, THEREFORE, in consideration of the mutual promises, covenants and
agreements set forth in this Agreement, Qualigen and Endocare agree as follows:

      Section 1. Appointment.

      1.1 Appointment of Endocare. Qualigen hereby appoints Endocare as a
non-exclusive distributor of the Products to Authorized Customers in the
Territory. Endocare may sell the Products either as an integral part of its
Diagnostic Workstation covered under a prior agreement, or as a stand-alone
product covered by this Agreement only to Authorized Customers in the Territory
(hereafter the "Market"). Nothing in this Agreement shall be construed to grant
any rights to Endocare to market or distribute the Products outside the
Territory or to any customers in the Territory that is not an Authorized
Customer.

      1.2 Parties Not Authorized to Act on Behalf of Each Other. Each party will
act on its own behalf in the performance of this Agreement and not as the agent
or legal representative of the other. This Agreement shall not be construed to
allow either party to create or assume any obligation on behalf of the other for
any purpose whatsoever. Endocare shall be solely responsible for and shall
indemnify and hold Qualigen free and harmless from any and all claims, damages
or lawsuits (including Qualigen's reasonable attorneys' fee) arising out of the
acts of Endocare, its employees or its agents.

      1.3 Endocare Affiliates and Subsidiaries. Endocare may perform its
obligations and exercise its rights under this Agreement itself or through an
affiliate or subsidiary of Endocare. Endocare shall impose on any affiliate or
subsidiary that sells or distributes Products hereunder the duty to comply with
the terms of this Agreement. The failure of any such affiliate, subsidiary or
other party to perform any such obligations hereunder shall be deemed a default
by Endocare under this Agreement on the same basis as Endocare's failure to so
perform would be a default. Invoices shall be issued to and product shall be
shipped to the entity specified in the applicable purchase order.

<PAGE>

      Section 2. Product Orders.

      2.1 Prices. Qualigen will sell Products to Endocare at the prices shown in
Exhibit "A."

                                       ***
                                      ***. Prices of the Products may be
changed from time to time by Qualigen through consultation between Qualigen and
Endocare, taking into account prevailing market conditions. Qualigen will
provide Endocare with sixty (60) days advance written notice of any price
changes. Such price changes shall apply only to orders received after the
effective date of the change. Price increases shall not affect unfulfilled
purchase orders accepted by Qualigen prior to the effective date of the price
increase.

      2.2 Order and Acceptance. All purchases of Product initiated by Endocare
shall be submitted by written purchase orders sent to Qualigen by mail or
facsimile and requesting a delivery date during the term of this Agreement. No
order shall be binding upon Qualigen until accepted by Qualigen in writing, and
Qualigen shall not have liability to Endocare with respect to purchase orders
that are not accepted in writing. Qualigen shall use its reasonable best efforts
to notify Endocare of the acceptance or rejection of an order and the assigned
delivery date for accepted orders within three (3) business days of receipt of
the purchase order. No partial shipment of an order shall constitute the
acceptance of the entire order, absent the written acceptance of such entire
order. Qualigen shall use its reasonable best efforts to deliver Products at the
times specified in its written acceptance of Endocare's purchase orders.

      2.3 Terms of Purchase Orders. Endocare's purchase orders submitted to
Qualigen shall be governed by the terms of this Agreement and nothing contained
in any such purchase orders shall modify the terms of purchase set forth on this
Agreement or add any additional terms or conditions. All purchase orders shall
be submitted by fax and paid for in accordance with the payment terms specified
in Section 3.2.

      Section 3. Shipment, Risk of Loss, Payment.

      3.1 Shipment, Title, Risk of Loss. All Products purchased by Endocare
shall be delivered to Endocare or a party designated by Endocare *** Qualigen's
plant, Carlsbad, California. ***
                                      ***
                                      ***.

      3.2 Payment. Endocare will make payment by check or wire transfer within
thirty (30) days from date of each invoice. Interest will be payable on payments
not received within thirty (30) days from the date of each invoice, at the rate
of *** per month on the unpaid balance or the maximum allowed under law,
beginning thirty (30) days from the date of invoice.

      Section 4. Representations and Obligations of Qualigen.

      4.1 Contractual Authority. Qualigen represents that it has full right,
title and unencumbered proprietary interest in and to the Products and full
authority to consummate the transactions contemplated herein. The granting by
Qualigen to Endocare of the non-exclusive right to sell the Products does not
require the consent, waiver, approval, or authorization of any person or
authority and does not violate any other agreements, instruments, or rights of
any third party.

*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

                                      -2-
<PAGE>

      4.2 Promotional Materials. Qualigen shall provide, in reasonable
quantities, sales and promotional material for the Products at Endocare's
expense.

      4.3 Non-Discriminatory Pricing. Qualigen will extend to Endocare pricing
terms equal to the lowest prices being offered by Qualigen to other distributors
of the Products to Authorized Customers in the Territory.

      4.4 Technical Service and Support. Qualigen will provide efficient
technical service and customer support to all customers of Endocare both during
and following any applicable warranty period. In the event that Qualigen is
unable to provide technical or customer support to the customers following the
warranty period, Qualigen will provide Endocare with all training and other
information and resources necessary to provide efficient technical service and
customer support on the Products.

      Section 5. Representations and Obligations of Endocare.

      5.1 Product Promotion. Endocare represents that it has experience in
marketing and selling related products to Authorized Customers in the Territory,
it has the financial resources to market the Products and it shall use
reasonable efforts to actively promote, market and sell the Products to
Authorized Customers in the Territory and seek to achieve the maximum
utilization potential in the Territory.

      5.2 Sales Forecasts. Endocare shall provide Qualigen with annual forecasts
of projected purchases of Products broken out on a quarterly basis and shall
update such forecasts throughout the year as reasonably requested by Qualigen
and as anticipated variances exceed more than *** of quarterly forecasted
amounts. Such forecasts shall be for planning purposes only and shall not
constitute binding purchase commitments.

      5.3 Sales Reports.Endocare shall deliver reports of sales, pricing, and
other information reasonably requested by Qualigen pertaining to the
distribution and marketing of the Products in the Territory.

      5.4 Regulatory Compliance. Endocare will cooperate fully with Qualigen to
provide and implement Product tracing and incident notification procedures
necessary to comply with FDA medical device reporting requirements and other
applicable federal and state legal requirements.

      5.5 Limitations of Authority. Endocare shall not solicit or receive
purchase orders from customers who are not Authorized Customers located in the
Territory.

      5.6 Competing Products. Endocare shall not directly or indirectly sell,
lease or otherwise distribute any product that, in Qualigen's reasonable
judgment, competes with the Products, without Qualigen's prior written consent.

      5.7 General Conduct. Endocare shall conduct its business so as to reflect
favorably on Qualigen and the Products.

*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

                                      -3-
<PAGE>

      Section 6. Shared Obligations of Qualigen and Endocare.

      6.1 Compliance with Laws and Regulations. Endocare and Qualigen shall
comply with all applicable laws, statutes, and regulations relating to
production, marketing, sales, and distribution of the Products in the Territory.

      6.2 Customer Requirements. Endocare shall assist Qualigen in assessing
customer requirements for the Products, including modifications and improvements
thereto, in terms of quality, design, functional capability and other features.

      6.3 Expenses and Personnel. Endocare and Qualigen shall be solely
responsible for their respective expenses and those of their staff and agents.

      Section 7. Warranty to Endocare's Customers

      7.1 Standard Limited Warranty. Endocare shall pass on to its customers
Qualigen's standard limited warranty for the Products set forth in Exhibit "B"
hereto, including the limitations set forth therein. The length of the "Warranty
Period," as defined in the standard Product Warranty, shall be:

      Analyzer and
      Accessories  - One year on all components.

      Reagent Packs - The lesser of one year or the expiration date
                      set forth on the label. Expiry dated products shall
                      have a minimum shelf life of twelve (12) weeks prior
                      to expiry date from the date of shipment.

      On Products manufactured by third parties and distributed by Qualigen, the
manufacturers warranty will be passed on to Endocare's initial purchaser.

      7.2 Warranty Service. Endocare agrees to act as a liaison between Qualigen
and Endocare's customers regarding warranted Products and, where appropriate, to
perform initial inspection of such Products prior to returning them to Qualigen
for warranty service.

      Section 8. Property Rights and Confidentiality

      8.1 Property Rights. Endocare agrees that Qualigen owns all right, title
and interest in the Product lines that include the Products now or hereafter
subject to this Agreement and in all of Qualigen's patents, trademarks, trade
names, inventions, copyrights, know-how and trade secrets relating to the
design, manufacture, operations or service of the Products. The use by Endocare
of any of these property rights is authorized only for the purposes herein set
forth and, upon termination of this Agreement for any reason, such authorization
shall cease. The Products are offered for sale and are sold by Qualigen subject
in every case to the condition that such sale does not convey any license,
expressly or by implication, to manufacture, duplicate, re-label or otherwise
copy or reproduce any of the Products.

        8.2 Confidentiality. Endocare acknowledges that by reason of its
relationship to Qualigen hereunder it will have access to certain information
and materials concerning Qualigen's business plans, customers, technology and
Products that are confidential and of substantial value to Qualigen, which value
would be impaired if such information were disclosed to third parties. Endocare
agrees that it will not use in any way for its own account or the account of any
third party, nor disclose to any third party, any such confidential information
revealed to it by Qualigen. Endocare shall take every reasonable

                                      -4-
<PAGE>

precaution to protect the confidentiality of such information. In the event of
termination of this Agreement, there shall be no use or disclosure by Endocare
of any confidential information of Qualigen, and Endocare shall not manufacture
or have manufactured any devices, components or assemblies utilizing any of
Qualigen's confidential information.

      Section 9. Trademarks and Trade Names.

      9.1 Use. During the term of this Agreement, Endocare shall have the right
to indicate to the public that it is an authorized distributor of Qualigen's
Products and to advertise (within the Territory) such Products under the
trademarks, marks and trade names that Qualigen may adopt from time to time
("Qualigen's Trademarks"). Endocare shall not alter or remove any Qualigen's
Trademark applied to the Products at the factory. At no time during or after the
term of this Agreement shall Endocare challenge or assist others to challenge
Qualigen's Trademarks or the registration thereof or attempt to register any
trademarks, marks or trade names confusingly similar to those of Qualigen.

      9.2 Approval of Representation. All representations of Qualigen's
Trademarks that Endocare intends to use shall first be submitted to Qualigen for
approval of design, color and other details or shall be exact copies of those
used by Qualigen. The use of any other mark on a Product in conjunction with the
Qualigen Trademarks also shall be submitted to Qualigen for approval under the
preceding sentence.

      Section 10. Patent, Copyright and Trademark Indemnity

      10.1 Indemnification. Qualigen shall, at its own expense, defend or settle
any claim, suit or proceeding brought against Endocare or its customer for
infringement of any United States or foreign patents or trademark by Products
sold hereunder, or the use thereof, subject to the limitations hereinafter set
forth. Qualigen shall have the sole control of any such action or settlement
negotiations and Qualigen agrees to pay, subject to the limitations hereinafter
set forth, any final judgment entered against Endocare or its customer on such
issue in any such suit or proceeding defended by Qualigen. Endocare agrees that
Qualigen shall be relieved of the foregoing obligations unless Endocare or its
customer notifies Qualigen promptly in writing of such claim, suit or proceeding
and gives Qualigen authority to proceed as contemplated herein.

      10.2 Limitation. Qualigen shall not be obligated to indemnify Endocare
under Section 10.1, above, if a claim for patent or trademark infringement is
the result of a modification of any Product which was not performed by Qualigen,
the use of a Product in combination with any other product or assembly not
supplied by Qualigen, or any markings or branding of a Product not applied by
Qualigen.

      10.3 Entire Liability. The foregoing provisions of this Section 10 state
the entire liability and obligations of Qualigen and the exclusive remedy of
Endocare and its customers with respect to any alleged patent or trademark
infringement by the Products or any part thereof.

      Section 11. Term and Termination.

      11.1 Term. The term of this Agreement shall commence on the date hereof
and continue for five (5) years. After the expiration of the initial five-year
term, this Agreement shall automatically renew for successive terms of one year
each until terminated by either party, with or without cause, on ninety (90)
days written notice.

      11.2 Termination for Cause. Either party may terminate this Agreement for
cause upon the breach by the other party of any material term or condition
hereof. Upon a material breach, the non-breaching party shall give the breaching

                                      -5-
<PAGE>

party thirty (30) days written notice of the breach. The breaching party shall
have thirty (30) days from the sending of the notice in which to cure its breach
and avoid termination.

      11.3 Termination Without Cause. Either party may termination this
Agreement without cause upon ninety (90) days' written notice to the other
party.

      11.4 Customer Supply Following Termination. In the event that Qualigen
elects to terminate this Agreement pursuant to Section 10.3 ("Termination
Without Cause"), hereof, Qualigen shall continue to sell FastPack test packs to
Endocare for a period of one (1) year thereafter in sufficient quantity to meet
the ongoing demands of customers to whom Endocare has sold FastPack Systems.
Following the end of such one-year period, Qualigen agrees to sell FastPack test
packs directly to such customers for as long as demand exists.

      Section 12. Indemnification, Disclaimer of Warranty, Limitation of
Liability.

      12.1 Endocare's Indemnification of Qualigen. Endocare shall, at Endocare's
sole cost and expense, indemnify, defend and hold Qualigen, its licensors and
service providers, and their respective officers, directors, employees, agents
and consultants harmless from and against any judgment or settlement and
associated litigation and/or settlement costs (including reasonable attorney's
fees and costs) that arise out of the negligent or intentionally tortious
conduct of Endocare's business, or Endocare's use or sale of Products delivered
to it by Qualigen. Qualigen shall provide Endocare with written notification of
any claim subject to indemnification pursuant to this Section 12 and of any
associated court filings promptly after Qualigen first learns of them. Qualigen
shall provide Endocare with such assistance and cooperation as Endocare may
reasonably request from time to time in connection with the defense thereof.
Qualigen will use reasonable efforts to mitigate all such claims, losses,
damages, expense or liability after receipt of notice thereof.

      12.2 Qualigen's Indemnification of Endocare. Qualigen shall, at Qualigen's
sole cost and expense, indemnify, defend and hold Endocare, its licensors and
service providers, and their respective officers, directors, employees, agents
and consultants harmless from and against any judgment or settlement and
associated litigation and/or settlement costs (including reasonable attorney's
fees and costs) that arise out the Products' failure to meet the applicable
Warranty and for any claims based on products liability theory against the
Products. Endocare shall provide Qualigen with written notification of any claim
subject to indemnification pursuant to this Section 12 and of any associated
court filings promptly after the Endocare first learns of them. Endocare shall
provide Qualigen with such assistance and cooperation as Qualigen may reasonably
request from time to time in connection with the defense thereof. Endocare will
use reasonable efforts to mitigate all such claims, losses, damages, expense or
liability after receipt of notice thereof.

      12.3 Cross Indemnification. Each party shall indemnify the other against
any and all loss, liability, cost or expense, including reasonable attorneys'
fees, in any way arising out of any breach of warranty or representation
hereunder, or any recklessness or willful misconduct in connection with the
implementation and carrying out of the terms of this Agreement.

      Section 13. Notices.

      13.1 Notices. Any notice, request, demand, or other communication required
or permitted hereunder shall be deemed to be properly given when received by fax
or received by mail, postage prepaid, addressed:

                                      -6-
<PAGE>

            To Endocare:

                    Endocare, Inc.
                    7 Studebaker
                    Irvine, CA  92618
                    U.S.A.
                    Attention:  ***

            To Qualigen:

                    Qualigen, Inc.
                    2042 Corte del Nogal
                    Carlsbad, CA  92009
                    Attention:  ***

      Section 14. General Provisions

      14.1 Governing Law. This Agreement will be interpreted and construed in
accordance with the laws of the State of California, excluding any choice of law
provisions, and without regard to which party drafted particular provisions of
the Agreement.

      14.2 Arbitration. Any claim, dispute or controversy under this Agreement,
including the interpretation of any of the provisions hereof, shall be settled
exclusively by arbitration in Los Angeles, California, and shall be conducted in
accordance with the then current Commercial Arbitration Rules of the American
Arbitration Association ("AAA"). The arbitrator shall be selected jointly by the
parties, but if the parties cannot agree upon an arbitrator within thirty (30)
days after a parties notifies the other party of its intention to arbitrate, the
arbitrator shall be appointed by the AAA. The arbitrator shall render a written
opinion stating the reasons for his decision within three (3) months after the
request for arbitration. The decision of the arbitrator shall be final and
binding upon the parties and shall not be subject to any rights of appeal.
Judgment upon an award may be entered in any competent court. Each party shall
be responsible for the fees and expenses of its legal counsel and the parties
shall share equally in the costs and charges of the AAA and of the arbitrator.

      14.3 Assignment. Neither Qualigen nor Endocare shall assign its rights or
obligations under this Agreement without the prior written consent of the other
party hereto; provided, however, that Qualigen may, without Endocare's consent,
assign this Agreement and its rights and obligations hereunder in connection
with the transfer or sale of all or substantially all of Qualigen's assets or
equity, or in the event of its merger or consolidation or change in control or
similar transaction.

      14.4. Entire Agreement. This Agreement sets forth the entire agreement and
understanding of the parties relating to the subject matter of this Agreement
and merges all prior discussions between them. No modification of or amendment
to this Agreement, or any waiver of any rights under this Agreement, shall be
effective unless in writing signed by the party to be charged.

      14.5. Headings. The descriptive headings of this Agreement have been
inserted for convenience and shall not be deemed to limit or otherwise affect
the construction of any provision hereof.

                                      -7-
<PAGE>

      14.6 Severability. If any provision of this Agreement is held to be
invalid by a court of competent jurisdiction, then the remaining provisions
shall nevertheless remain in full force and effect. The parties agree to
re-negotiate in good faith any term held invalid and to be bound by the mutually
agreed substitute provision.

      14.7 Counterparts. This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which
together shall constitute but one and the same instrument.

      IN WITNESS WHEREOF, the parties hereby execute this Agreement as of the
date set forth above.

ENDOCARE, INC.                          QUALIGEN, INC.
a Delaware Corporation                  a Delaware Corporation

By: /s/ Paul Mikus                      By: /s/ Michael S. Poirier
    -------------------------------         ---------------------------------
    Paul Mikus                              Michael S. Poirier
    Chairman & CEO                          Chairman & CEO

                                      -8-
<PAGE>

                                   EXHIBIT "A"

                                   PRICE LIST

<TABLE>
<CAPTION>
Part Number       Product Description                                     Endocare Price
-----------       -------------------                                     --------------
<S>               <C>                                                     <C>
                  SYSTEMS
20000001          FASTPACK(TM) SYSTEM                                            ***

                      Contents:  FastPack Analyzer
                                 FastPack Power/Air Supply
                                 FastPack Sample Dispenser
                                 Multilingual Procedure Manual
                                 FastPack Training Video
                                 Ink Cartridge Kit

                  FASTPACK CASSETTES

                        ***:

25000001          FastPack Total PSA Kit-50                                      ***

25000006          FastPack Free PSA Kit-50                                       ***

25000007          FastPack Testosterone Kit-50                                   ***

                        ***:

25000001          FastPack Total PSA Kit-50                                      ***

25000006          FastPack Free PSA Kit-50                                       ***

25000007          FastPack Testosterone Kit-50                                   ***

                  CALIBRATION PRODUCTS
25000002          FastPack Calibrator Kit                                        ***

250000003         FastPack Controls Kit                                          ***

                  OTHER PRODUCTS
20000009          FastPack Stacking Bracket                                      ***

20000010          Tricontinent(TM) Plastic Pipette                               ***

17000034          Eppendorf(TM) Pipette Tips Pack (qty: 96)                      ***

17000015          US Power Cord (already included in FastPack System)            ***
</TABLE>

*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

                                      -9-
<PAGE>

<TABLE>
<S>               <C>                                                            <C>
20000011          Ink Cartridge Kit                                              ***

65000001          Procedure Manual--Multilingual                                 ***

68000004          CLIA Compliance Manual                                         ***
</TABLE>

          (C) 2001 Qualigen, Inc. All rights reserved. Qualigen and FastPack are
trademarks or registered trademarks of Qualigen, Inc. All other trademarks are
the property of their respective owners.

*** Portions of this page have been omitted pursuant to a request for
    Confidential Treatment and filed separately with the Commission.

                                      -10-
<PAGE>

                                   EXHIBIT "B"

                   LIMITED WARRANTY TO DISTRIBUTOR'S CUSTOMERS

The "Warranty Period" for each Product is set forth in the Distribution
Agreement. Qualigen will provide the following limited warranty for the Products
to the initial purchaser ("Customer") from Distributor. Qualigen warrants that
throughout the applicable Warranty Period the Products will be free from defects
in materials and workmanship and will perform as set forth in Qualigen'
published product specification and operator manual in effect at the time of
delivery.

Qualigen's liability for all matters arising under this warranty shall be
limited solely to the repair or (in Qualigen's sole discretion) replacement of
the Product. If Qualigen reasonably determines that a repair or replacement is
covered by this warranty, Qualigen shall bear the cost of shipping the repaired
or replacement Product to the Customer. All other shipping costs shall be paid
by the Customer. Risk of loss or damage during shipments under this warranty
shall be the responsibility of the party shipping the Product. If Product
shipped to Qualigen under this warranty is not suitably packaged for shipment,
any physical damage present in the Product on receipt by Qualigen (and not
previously reported) shall be presumed to have occurred in transit and will be
the responsibility of the Customer.

Qualigen shall not be obligated under this warranty if the need for repairs or
replacements directly or indirectly results from Customer's: (i) failure to use
or store the Product as specified by Qualigen; (ii) failure to properly perform
the services or maintenance required in the Operator's Manual for a Product;
(iii) repairs to a Product by persons other than Qualigen service personnel;
(iv) replacement of parts with other than Qualigen genuine parts; (v) negligence
or negligent operation of any Product; or (vi) alterations or modifications of
any Product without authorization from Qualigen.

THIS WARRANTY, TOGETHER WITH ANY OTHER WRITTEN WARRANTY THAT MAY BE ISSUED BY
QUALIGEN, IS THE SOLE AND EXCLUSIVE WARRANTY AS TO QUALIGEN' PRODUCTS, EXTENDS
ONLY TO THE CUSTOMER AND IS EXPRESSLY IN LIEU OF ANY ORAL OR IMPLIED WARRANTIES
INCLUDING WITHOUT LIMITATION ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS
FOR A PARTICULAR PURPOSE OR WARRANTY AGAINST INFRINGEMENT.

                             LIMITATION OF LIABILITY

EXCEPT AS PROVIDED IN THE PRODUCT LIABILITY INDEMNIFICATION AGREEMENT OF THE
DISTRIBUTION AGREEMENT, IN NO EVENT SHALL QUALIGEN BE LIABLE TO DISTRIBUTOR OR
ITS CUSTOMERS OR ANY OTHER PERSON FOR INCIDENTAL, SPECIAL OR CONSEQUENTIAL
DAMAGES OR LOST PROFITS, EVEN IF QUALIGEN HAS BEEN ADVISED OF THE POSSIBILITY
THEREFOR, ARISING OUT OF OR IN CONNECTION WITH THE SALE, DELIVERY, INSTALLATION,
USE, LOSS OF USE, REPAIR OR PERFORMANCE OF THE PRODUCTS, INCLUDING ALL ADDITIONS
TO AND REPLACEMENTS OF THE PRODUCTS OR ANY FAILURE OR DELAY IN CONNECTION WITH
ANY OF THE FOREGOING.

                                      -11-

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