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                                                                   Exhibit 10.22

SILICON VALLEY BANK

                    AMENDMENT TO LOAN AND SECURITY AGREEMENT

BORROWER: ISILON SYSTEMS, INC., A DELAWARE CORPORATION

DATED AS OF: MARCH 10, 2005

      THIS AMENDMENT TO LOAN AGREEMENT is entered into between SILICON VALLEY
BANK ("Silicon") and the borrower named above (the "Borrower"). The Parties
agree to amend the Loan and Security Agreement between them, dated June 24,
2004, as amended or otherwise modified from time to time (the "Loan Agreement"),
as follows, effective as of the date hereof. (Capitalized terms used but not
defined in this Amendment, shall have the meanings set forth in the Loan
Agreement.)

      1. REVISED SCHEDULE TO LOAN AGREEMENT. The Schedule to Loan Agreement is
hereby amended and restated to read as is set forth on the Schedule to Loan
Agreement as is attached hereto.

      2. REVISED DEFINITION. The definition of "Eligible Accounts" as set forth
in Section 8 of the Loan Agreement is hereby amended to read as follows:

      "Eligible Accounts" means Accounts arising in the ordinary course of
      Borrower's business from the sale of goods or the rendition of services,
      or the non-exclusive licensing of Intellectual Property, which Silicon, in
      its good faith business judgment, shall deem eligible for borrowing.
      Without limiting the fact that the determination of which Accounts are
      eligible for borrowing is a matter of Silicon's good faith business
      judgment, the requirements in the remainder of this definition (the
      "Minimum Eligibility Requirements") are the minimum requirements for an
      Account to be an Eligible Account: (i) the Account must not be outstanding
      for more than 90 days from its invoice date (the "Eligibility Period"),
      (ii) the Account must not represent progress billings, or be due under a
      fulfillment or requirements contract with the Account Debtor, (iii) the
      Account must not be subject to any contingencies (including Accounts
      arising from sales on consignment, guaranteed sale or other terms pursuant
      to which payment by the Account Debtor may be conditional), (iv) the
      Account must not be owing from an Account Debtor with whom Borrower has
      any dispute (whether or not relating to the particular Account), (v) the
      Account must not be owing from an Affiliate of Borrower, (vi) the Account
      must not be owing from an Account Debtor which is subject to any
      insolvency or bankruptcy proceeding, or whose financial condition is not
      acceptable to Silicon, or which, fails or goes out of a material portion
      of its business, (vii) the Account must not be owing from the United
      States or any department, agency or instrumentality thereof (unless there
      has been compliance, to Silicon's satisfaction, with the United States
      Assignment of Claims Act), (viii) the Account must not be owing from an
      Account Debtor located outside the United States or those provinces or
      territories of Canada that have adopted the Personal Property Security Act
      (unless pre-approved by Silicon in its discretion in writing, or backed by
      a letter of credit satisfactory to Silicon, or FCIA insured satisfactory
      to Silicon) (with any such Accounts so owing from such Account Debtors
      being

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      referred to herein as the "Foreign Accounts" and any such Foreign Accounts
      that would otherwise be deemed Eligible Accounts hereunder apart from the
      foreign location of the Account Debtors are referred to herein as the
      "Foreign Eligible Accounts"), (ix) the Account must not be owing from an
      Account Debtor to whom Borrower is or may be liable for goods or services
      purchased by Borrower, or third-party intellectual property licensed by
      Borrower (as licensee), from such Account Debtor or otherwise (but, in
      such case, the Account will be deemed not eligible only to the extent of
      any amounts owed by Borrower to such Account Debtor) *. Accounts owing
      from one Account Debtor will not be deemed Eligible Accounts to the extent
      they exceed 25% ** of the total Accounts outstanding. In addition, if more
      than 50% of the Accounts owing from an Account Debtor are outstanding for
      a period longer than their Eligibility Period (without regard to unapplied
      credits) or are otherwise not eligible Accounts, then all Accounts owing
      from that Account Debtor will be deemed ineligible for borrowing. Silicon
      may, from time to time, in its good faith business judgment, revise the
      Minimum Eligibility Requirements, upon written notice to Borrower.

      * , PROVIDED THAT THE FOREGOING SHALL NOT APPLY TO EXCLUDE ANY AMOUNTS
      OWING BY AN ACCOUNT DEBTOR AS TO WHOM BORROWER HAS RECOGNIZED OR CAN
      RECOGNIZE DEFERRED REVENUE (THEREBY RENDERING DEFERRED REVENUE AMOUNTS
      ELIGIBLE PORTIONS OF ACCOUNTS TO THE EXTENT ANY SUCH ACCOUNTS ARE
      OTHERWISE DEEMED ELIGIBLE ACCOUNTS., AND (XI) THE ACCOUNT MUST HAVE BEEN
      BILLED TO THE ACCOUNT DEBTOR.

      ** (OR, IN THE CASE OF THE ACCOUNT DEBTOR KNOWN AS OFOTO, 50%)

      3. PERMITTED NEW SUBORDINATED DEBT. Borrower has informed Silicon that it
anticipates entering into a subordinated debt financing transaction in the
forthcoming year in an approximate dollar amount of $5,000,000. Silicon
acknowledges and consents to such type of transaction, subject to the execution
and delivery of a debt and lien subordination agreement in form and substance
acceptable to Silicon.

      4. CONDITION TO EFFECTIVENESS. The effectiveness of this Amendment is
conditioned upon the occurrence of all of the following:

            (a) A certificate of the Secretary or the Assistant Secretary of
Borrower, in form and substance satisfactory to Silicon, certifying the adoption
of resolutions of the Board of Directors of Borrower approving this Agreement
and the transactions contemplated hereby (including the documents, instruments
and agreements described in this Section) is delivered to Silicon, in form
acceptable to Silicon.

            (b) A new ten year Warrant to Purchase Stock is issued to the
Silicon regarding 250,000 shares of Series C Preferred Stock of the Borrower at
an initial exercise price of $0.60 per share together with other rights and
provisions as are acceptable to Silicon.

            (c) Borrower's payment of the fee to Silicon as set forth in the
Amended and Restated Schedule to Loan Agreement attached hereto in the aggregate
amount of $______________ and payment of all Bank Expenses relating hereto;

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            (d) Counterparts of this Agreement have been duly executed and
delivered to the Administrative Agent by all parties thereto.

      5. REPRESENTATIONS TRUE. Borrower represents and warrants to Silicon that
all representations and warranties set forth in the Loan Agreement, as amended
hereby, are true and correct.

      6. GENERAL PROVISIONS. This Amendment, the Loan Agreement, any prior
written amendments to the Loan Agreement signed by Silicon and the Borrower, and
the other written documents and agreements between Silicon and the Borrower set
forth in full all of the representations and agreements of the parties with
respect to the subject matter hereof and supersede all prior discussions,
representations, agreements and understandings between the parties with respect
to the subject hereof. Except as herein expressly amended, all of the terms and
provisions of the Loan Agreement, and all other documents and agreements between
Silicon and the Borrower shall continue in full force and effect and the same
are hereby ratified and confirmed. This Agreement and Consent may be executed in
any number of counterparts, which when taken together shall constitute one and
the same agreement.

      IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of
the date first above written.

BORROWER:                          SILICON:

ISILON SYSTEMS, INC.               SILICON VALLEY BANK

BY /s/ STUART W. FUHLENDORF        BY /s/ PATRICK MCCARTHY
   ------------------------------     --------------------------------
   TITLE: CFO                      TITLE SR. VICE PRESIDENT

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                                                                  Exhibit 10.23

SILICON VALLEY BANK

                    AMENDMENT TO LOAN AND SECURITY AGREEMENT

BORROWER: ISILON SYSTEMS, INC., A DELAWARE CORPORATION

DATED AS OF: MARCH 21, 2005

      THIS AMENDMENT TO LOAN AGREEMENT is entered into between SILICON VALLEY
BANK ("Silicon") and the borrower named above (the "Borrower"). The Parties
agree to amend the Loan and Security Agreement between them, dated June 24,
2004, as amended or otherwise modified from time to time (the "Loan Agreement"),
as follows, effective as of the date hereof. (Capitalized terms used but not
defined in this Amendment, shall have the meanings set forth in the Loan
Agreement.)

      1. AMENDED SCHEDULE TO LOAN AGREEMENT. Section 8 of the Schedule to Loan
Agreement entitled "Additional Provisions" is hereby amended by replacing
paragraph (8) thereof that now reads as "(8) [Intentionally Omitted] with the
following:

      "(8) ADDITIONAL TRANSACTIONS. Borrower shall consummate an Subordinated
Debt or equity financing transaction, in each case containing terms and
conditions reasonably acceptable to Silicon (a "Transaction"), yielding at least
$5,000,000 in net proceeds thereof to Borrower no later than July 30, 2005.
Further, Borrower shall consummate an additional Transaction yielding at least
$10,000,000 in net proceeds to Borrower no later than November 15, 2005."

      2. GENERAL PROVISIONS. Except as herein expressly amended, all of the
terms and provisions of the Loan Agreement, and all other documents and
agreements between Silicon and the Borrower shall continue in full force and
effect and the same are hereby ratified and confirmed.

      IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of
the date first above written.

BORROWER:                          SILICON:

ISILON SYSTEMS, INC.               SILICON VALLEY BANK

BY /s/STUART W. FUHLENDORF         BY /s/ PATRICK MCCARTHY
   ------------------------------     --------------------------------
   TITLE: CFO                      TITLE SR. VICE PRESIDENT

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