Document:

EX-10.2

 Exhibit 10.2 

FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT 

THIS FIRST AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (this “Amendment”) is made and entered into this 13th day of October, 2015 by and
between Cempra, Inc., a Delaware corporation with its principal executive offices at 6320 Quadrangle Drive, Suite 360, Chapel Hill, NC 27517 (the “Company”), and Prabhavathi Fernandes, Ph.D. (the “Executive”). 

WITNESSETH: 
 WHEREAS,
Executive and the Company previously entered into an Executive Employment Agreement (the “Employment Agreement”) as of August 9, 2013; 

WHEREAS, Executive and the Company wish to amend the Employment Agreement to alter certain provisions regarding the consideration to be paid
to Executive under certain circumstances following a termination of Executive’s employment with the Company; and 
 WHEREAS, in light
of the foregoing, Executive and the Company desire to mutually and voluntarily amend the Employment Agreement, effective as of the date set forth above (the “Effective Date”), pursuant to the terms set forth herein. 

NOW, THEREFORE, in consideration of the foregoing, the mutual promises herein contained, and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, agree as follows. 
 1.
AMENDMENT TO SECTION 10(d) OF THE EMPLOYMENT AGREEMENT. Section 10 of the Employment Agreement is modified by replacing existing Section 10(d) with a new Section 10(d) as follows: 

(d) If Executive’s employment is terminated by the Company without Cause (and not due to the expiration and non-renewal of the Term or
Executive’s death or Disability) or by Executive for Good Reason, the Company will pay her the Base Salary through the date of her termination, plus her Target Bonus based upon the average percentage of achievement of target objectives for the
prior three (3) years, pro rated through the date of her termination, all minus applicable withholdings required by law or authorized by Executive, plus any unpaid reimbursement amounts for business expenses incurred through the date of
termination, and, in addition, if (i) such termination results in Executive incurring a “separation from service” as defined under Treasury Regulation 1.409A-1(h); (ii) Executive has not breached this Agreement; and
(iii) Executive signs and does not revoke within sixty (60) days after the termination date a general release of claims against the Company related to her employment (the “Release”), in form and substance satisfactory to the
Company the Company shall: 
 (i) Continue to pay to Executive an amount equal to her Base Salary for a period of eighteen (18) months
following such termination, plus one and one half 

 
times her Target Bonus based upon the average percentage of achievement of target objectives for the prior three (3) years, payable in eighteen (18) equal monthly payments, all minus
any federal, state and local payroll taxes and other withholdings legally required or properly requested by Executive; and 
 (ii)
Conditioned on Executive’s proper and timely election to continue her health insurance benefits under COBRA after the Termination Date, reimburse Executive’s applicable COBRA premiums for the lesser of eighteen (18) months following
the Termination Date or until Executive becomes eligible for insurance benefits from another employer. 
 The Company shall pay the Base
Salary and any pro rated Target Bonus in accordance with the Company’s regular payroll schedule, beginning within fifteen (15) days immediately following her termination. Notwithstanding the foregoing, any amount that would be payable
within the 60-day period following Executive’s termination if Executive signed and did not revoke the general release on the day of her termination shall be delayed until the 61st day
following Executive’s termination. The Company shall pay the COBRA payment on the first day of the month immediately following the month to which it relates, provided, however hat the Company has the right to terminate such payment of COBRA
premium reimbursement to Executive and instead pay Executive a lump sum amount equal to the applicable COBRA premium multiplied by the number of months remaining in the specified period if the Company determines in its discretion that continued
payment of the COBRA premiums is or may be discriminatory under Section 105(h) of the Internal Revenue Code. Each such COBRA payment (or the lump sum payment, if applicable) shall be treated as taxable wages to Executive. The Company shall pay
any other amounts due pursuant to this paragraph at the same time the amount would have been paid had Executive remained employed by the Company. 

(iii) Except as provided under the terms of the Company’s employee benefit plans or as provided by that certain Change in Control
Severance Agreement of even date herewith, Executive shall have no further entitlement to any other compensation or benefits from the Company. 

2. REMAINDER OF EMPLOYMENT AGREEMENT. Except as expressly set forth in this Amendment, the provisions of the Employment Agreement will
remain in full force and effect, in their entirety, in accordance with their terms. 
 3. MISCELLANEOUS. This Amendment will be
governed, construed, and interpreted in accordance with the laws of the State of North Carolina, without giving effect to conflicts of laws principles of any jurisdiction. The parties agree that this Amendment may only be modified in a signed
writing executed by each of the parties hereto. This Amendment will be binding upon and will inure to the benefit of the parties hereto and their respective heirs, successors and assigns. This Amendment may be executed in separate counterparts, each
of which is deemed to be an original and all of which taken together constitute one agreement. Facsimile or PDF reproductions of original signatures will be deemed binding for the purpose of the execution of this Amendment. 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Amendment to be effective as of the
Effective Date. 
  

			
	CEMPRA, INC.
		
	By:	 	 /s/ Garheng Kong, M.D., Ph.D.

	Name:	 	Garheng Kong, M.D., Ph.D.
	Title:	 	Chairman of the Board of Directors

  

			
	EXECUTIVE
		
	By:	 	 /s/ Prabhavathi Fernandes, Ph.D.

	Name:	 	Prabhavathi Fernandes, Ph.D.

  
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 Exhibit 10.3 

FIRST AMENDMENT TO CHANGE IN CONTROL SEVERANCE AGREEMENT 

THIS FIRST AMENDMENT TO CHANGE IN CONTROL SEVERANCE AGREEMENT (this “Amendment”) is made and entered into this 13th day of
October, 2015 by and between Cempra, Inc., a Delaware corporation with its principal executive offices at 6320 Quadrangle Drive, Suite 360, Chapel Hill, NC 27517 (the “Company”), and Prabhavathi Fernandes, Ph.D. (the
“Employee”). 
 WITNESSETH: 

WHEREAS, Employee and the Company previously entered into a Change in Control Severance Agreement (the “Severance Agreement”)
as of August 9, 2013; 
 WHEREAS, Employee and the Company wish to amend the Severance Agreement to alter certain provisions regarding
the consideration to be paid to Employee under certain circumstances following a “Change in Control” of the Company and to make other clarifying amendments; and 

WHEREAS, in light of the foregoing, Employee and the Company desire to mutually and voluntarily amend the Severance Agreement, effective as of
the date set forth above (the “Effective Date”), pursuant to the terms set forth herein. 
 NOW, THEREFORE, in
consideration of the foregoing, the mutual promises herein contained, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, agree as follows. 

1. AMENDMENT TO SECTION 1(d) OF THE SEVERANCE AGREEMENT. Section 1 of the Severance Agreement is modified by replacing existing
Section 1(d)(v) with a new Section 1(d)(v) as follows: 
 (v) The determination by the Company, after a reasonable and good-faith
investigation by the Company following a written allegation by another employee of the Company, that Employee personally engaged in some form of discrimination, harassment or retaliatory conduct prohibited by law (including, without limitation,
discrimination based on race, color, religion, sex, national origin, age, disability or other status protected by law), unless Employee’s actions were specifically directed by the Board; 

2. AMENDMENT TO SECTION 1(f) OF THE SEVERANCE AGREEMENT. Section 1 of the Severance Agreement is modified by replacing existing
Section 1(f) with a new Section 1(f) as follows: 
 (f) “Good Reason” shall mean any of the following:
(i) the assignment to Employee of duties materially inconsistent with Employee’s position, duties, responsibilities, titles or offices as described herein; (ii) any material reduction by the Company of Employee’s duties and
responsibilities or any material change in 

 
Employee’s direct reporting relationship to the Board other than a change in the composition of the Board; (iii) any reduction or series of reductions in excess of ten percent
(10%) by the Company of Employee’s compensation or benefits payable hereunder (it being understood that a reduction of benefits applicable to all employees of the Company, including Employee, shall not be deemed a reduction of
Employee’s compensation package for purposes of this definition); or (iv) a change of more than thirty-five (35) miles in the geographic location at which Employee must perform services for the Company. Notwithstanding the foregoing,
Employee shall not have Good Reason for termination unless Employee gives written notice of termination for Good Reason within thirty (30) days after the event giving rise to Good Reason occurs, and the Company does not correct the action or
failure to act that constitutes the grounds for Good Reason, as set forth in Employee’s notice of termination, within thirty (30) days after the date on which Employee gives written notice of termination. 

3. AMENDMENT TO SECTION 2 OF THE SEVERANCE AGREEMENT. Section 2 of the Severance Agreement is modified by replacing existing
Section 2(b)(iii) with a new Section 2(b)(iii) as follows: 
 (iii) Conditioned on Employee’s proper and timely election to
continue her health insurance benefits under COBRA after the Termination Date, reimbursement of Employee’s applicable COBRA premiums for the lesser of twenty-four (24) months following the Termination Date or until Employee becomes
eligible for insurance benefits from another employer, provided, however, that the Company has the right to terminate such payment of COBRA premium reimbursement to Employee and instead pay Employee a lump sum amount equal to the applicable COBRA
premium multiplied by the number of months remaining in the specified period if the Company determines in its discretion that continued payment of the COBRA premiums is or may be discriminatory under Section 105(h) of the Internal Revenue Code.

 4. REMAINDER OF SEVERANCE AGREEMENT. Except as expressly set forth in this Amendment, the provisions of the Severance Agreement
will remain in full force and effect, in their entirety, in accordance with their terms. 
 5. MISCELLANEOUS. This Amendment will be
governed, construed, and interpreted in accordance with the laws of the State of North Carolina, without giving effect to conflicts of laws principles of any jurisdiction. The parties agree that this Amendment may only be modified in a signed
writing executed by each of the parties hereto. This Amendment will be binding upon and will inure to the benefit of the parties hereto and their respective heirs, successors and assigns. This Amendment may be executed in separate counterparts, each
of which is deemed to be an original and all of which taken together constitute one agreement. Facsimile or PDF reproductions of original signatures will be deemed binding for the purpose of the execution of this Amendment. 

  
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 IN WITNESS WHEREOF, the parties hereto have executed this Amendment to be effective as of the
Effective Date. 
  

			
	CEMPRA, INC.
		
	By:	 	 /s/ Garheng Kong, M.D., Ph.D.

	Name:	 	Garheng Kong, M.D., Ph.D.
	Title:	 	Chairman of the Board of Directors

  

			
	EMPLOYEE
		
	By:	 	 /s/ Prabhavathi Fernandes, Ph.D.

	Name:	 	Prabhavathi Fernandes, Ph.D.

  
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