Document:

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                                                                   EXHIBIT 10.64

                       ASSIGNMENT, ASSUMPTION AND CONSENT

SECTION I: ASSIGNMENT OF LEASE

        For valuable consideration, the receipt and adequacy of which are hereby
acknowledged, the undersigned, THE KRIEGSMAN CAPITAL GROUP, LLC, a California
limited liability company ("Assignor"), hereby assigns and transfers to CytRx
CORPORATION, a Delaware corporation ("Assignee"), all of Assignor's right,
title and interest in and under that certain Office Lease dated April 13, 2000
(the "Lease"), between DOUGLAS EMMETT JOINT VENTURE, a California general
partnership, as Landlord, and Assignor, as Tenant, covering that certain space
more commonly known as Suite 650 (the "Premises"), located at 11726 San Vicente
Boulevard, Los Angeles, California 90049 (the "Building"), as more particularly
described in the Lease.

        This Assignment is made pursuant to the provisions of Article 11 of the
Lease and in connection therewith the undersigned:

        a) Agrees the effectiveness of this Assignment and the Assumption of
        Lease provided for herein are subject to the consent of Landlord, which
        consent is predicated upon satisfaction of the conditions set forth in
        Section 3 of this instrument.

        b) Agrees that Assignor and Guarantor shall continue to remain
        personally liable for the payment of all amounts payable by the Tenant
        and the performance of all obligations of the Tenant pursuant to the
        Lease, subject to the terms of Article 24 of the Lease. In the event
        Assignee shall hold over, enter into a new lease or modification of the
        existing lease, Assignor and Guarantor shall be released from Assignor's
        and Guarantor's personal liability for any of the obligations of the
        Tenant under the Lease as of such date.

        c) Warrants that, as of the Effective Date specified below, there will
        be no uncured default on the part of Assignor pursuant to the Lease, and
        agrees to indemnify and defend Assignee against any claims arising out
        of such a claimed default.

        d) Acknowledges that Assignor has read the disclaimer set forth in
        Section 4 and the general provisions set forth in Section 5 of this
        instrument and executes this instrument with full knowledge and
        acceptance of such sections, both of which are incorporated herein.

This Assignment shall be effective as of July 1, 2003 (the "Effective Date").

SECTION 2: ASSUMPTION OF LEASE

        Assignee hereby accepts the foregoing assignment and assumes and agrees
to be bound by and perform all obligations of the Tenant pursuant to the Lease
arising on or after the Effective Date and to abide by all of the terms,
provisions, covenants and conditions of the Lease, including but not limited to
those providing for the payment of Rent, Additional Rent and other charges. The
undersigned acknowledges and agrees that:

        a)      It has inspected the Premises and the Building and has received
                and read a copy of the Lease and is assuming the obligations of
                Tenant pursuant to the Lease based upon its own independent
                investigation, and not upon any statements or representations
                made by or on behalf of the Landlord.

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        b)      In connection with this transaction, no person has had any
                authority to make any representations on behalf of Landlord
                concerning the Premises and/or the Building and such
                representations, if any, have not been relied upon by the
                undersigned.

        c)      The effectiveness of this Assumption and the Assignment of Lease
                provided for herein are subject to the consent of Landlord,
                which consent is predicated upon satisfaction of the conditions
                set forth in Section 3 of this instrument.

        d)      There may be no further assignment or transfer of the Lease or
                subletting of the Premises, or any portion thereof.

        e)      There may be no change in the use of the Premises, except that
                Landlord shall permit Assignee to use the Premises as an
                administrative office for a pharmaceutical company, and there
                shall be no remodeling of or alterations to the Premises
                without, in each instance, the prior written consent of Landlord
                and in conformance with the terms of the Lease.

        f)      Assignee's use of the Premises shall not conflict with other
                exclusive use provisions in current leases ( or with exclusive
                use provisions in future leases, which do not, when made,
                conflict with Assignee's actual and specifically permitted use
                of the Premises).

        g)      If Assignee defaults in payment or performance of any Tenant
                obligation accruing after the Effective Date, Assignee shall
                indemnify and hold Assignor harmless against any liability
                therefor and shall promptly reimburse Assignor for all amounts
                paid by Assignor to cure any such default, together with
                interest thereon at the rate specified in the Lease from date of
                expenditure to date of repayment.

        h)      Assignee has read the disclaimer set forth in Section 4 and the
                general provisions set forth in Section 5 of this instrument and
                executes this instrument with full knowledge and acceptance of
                such sections, both of which are incorporated herein.

SECTION 3: CONSENT TO ASSIGNMENT

        Contingent upon Assignor's and Assignee's acceptance of the requirements
contained hereinbelow, Landlord hereby consents to the foregoing Assignment in
accordance with the provisions of Article 11 of the Lease. Said consent is
subject to Assignor and Assignee acknowledging and agreeing that:

        a)      The foregoing consent is not a waiver of Landlord's right to
                consent to or impose restrictions upon any future assignment or
                subletting.

        b)      Nothing contained herein shall be deemed or construed to relieve
                Assignor of any obligation of the Tenant pursuant to the Lease,
                whether accrued through the Effective Date or thereafter.

        c)      Landlord now holds a security deposit pursuant to the Lease of
                $20,508.46, which sum shall continue to be held by Landlord
                after the Effective Date. Adjustments concerning such deposit
                are the sole responsibility of Assignor and Assignee, and
                Landlord need not be concerned therewith. At the expiration of
                the term of the Lease, Landlord shall return said security
                deposit in accordance with the terms of the Lease to Assignee.

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        d)      The foregoing consent does not include a consent to the transfer
                of any renewal, extension or expansion rights, or any other
                special privileges or rights granted to Tenant pursuant to the
                Lease and all such rights and privileges shall terminate upon
                the Effective Date.

        e)      In the event of any defaults under the Lease, Landlord will send
                to Assignor any notice of such default that Landlord sends to
                Assignee.

        This consent shall become effective only upon the execution of a copy of
this instrument by each other party hereto and delivery of such fully executed
copy to the undersigned.

SECTION 4: DISCLAIMER

        Assignor and Assignee each acknowledge that the Lease, as currently
amended, provides for payment of Additional Rent (as that term is defined in the
Lease) periodically on an estimated basis with adjustment to actual amounts due
as specified in the Lease. Notwithstanding any estimate or allocation of such
amounts provided by Landlord to Assignor and Assignee to facilitate the transfer
provided for herein, Assignor and Assignee understand and acknowledge that (i)
any such estimate or allocation is only an estimate by Landlord and is not
intended as and shall not be construed as a limitation or ceiling upon the
actual amounts which may be due, (ii) as respects Landlord, Assignee shall be
solely responsible for any additional amounts of Additional Rent due to Landlord
by virtue of such adjustments and shall be solely entitled to any refunds or
credits resulting from such adjustments, and (iii) any proration of any such
amounts between Assignor and Assignee shall be strictly between them, and
Landlord need not be concerned therewith.

SECTION 5: GENERAL PROVISIONS

        a)      If any party hereto commences any action against any other party
                hereto arising out of or in connection with this instrument, or
                the Lease, the prevailing party or parties shall be entitled to
                recover from the losing party or parties reasonable attorneys'
                fees as determined by the court as well as costs of suit.

        b)      Any notice, demand, request, consent, approval or communication
                that any party hereto desires or is required to give to any
                other party or parties hereto shall be in writing and either
                served personally or sent by prepaid, first class mail properly
                addressed and deposited in the State of California to the
                address appearing below the signatures of each party hereto.
                Notice shall be deemed communicated three business days after
                the time of mailing if mailed as provided in this paragraph.

        c)      Assignor and Assignee agree that Landlord has no liability for
                any fees or commissions to any real estate broker or agent in
                connection with the assignment and assumption of the Lease. All
                such fees and commissions shall be the responsibility of
                Assignor and Assignee.

        d)      This instrument shall be binding upon and inure to the benefit
                of the parties hereto and their respective successors in
                interest.

        e)      In the event of any conflict between the terms of this
                instrument and the terms of the Lease, the terms of the Lease
                shall control.

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        f)      In connection with the within assignment, and to defray the
                costs of processing such assignment, and Landlord's legal fees,
                Assignor shall pay to Douglas, Emmett and Company upon
                Landlord's execution of this instrument a processing fee
                of$750.00.

IN WITNESS WHEREOF, the parties hereto have affixed their signatures the date
hereinbelow.

ASSIGNOR:                                 ASSIGNEE:
THE KRIEGSMAN CAPITAL GROUP, LLC,         CytRx CORPORATION,
a California limited liability company    a Delaware corporation

By: /s/ Steven A. Kriegsman               By: /s/ Steven A. Kriegsman
   -----------------------------------       ---------------------------------

Signer's Name: Steven Kriegsman           Signer's Name: Steven Kriegsman
               -----------------------                   ---------------------
[X] President [ ] Vice President or       [ ] President [ ] Vice President or
[ ] Chief Executive Officer               [X] Chief Executive Officer
        (Check Title Above)                       (Check Title Above)

              and                                         and

By: /s/ Edward Umali                      By: /s/ Kathy R. Hernandez
   -----------------------------------       ---------------------------------

Signer's Name: Edward Umali               Signer's Name: Kathy Hernandez
               -----------------------                   ---------------------
[ ] Secretary [ ] Treasurer or            [X] Secretary [ ] Treasurer or
[ ] Chief Financial Officer               [ ] Chief Financial Officer
[X]Managing Director                               (Check Title Above)
        (Check Title Above)

Dated: 9/9/03                             Dated: 9/9/03
       ------

Notice Address:                           Notice Address:

11726 San Vicente Boulevard, Suite 650    11726 San Vicente Boulevard,
Los Angeles, California 90049             Suite 650
                                          Los Angeles, California 90049

LANDLORD:                                 GUARANTOR:
DOUGLAS EMMETT JOINT VENTURE
a California general partnership          /s/ Steven A. Kriegsman
                                          -----------------------------------
By: DOUGLAS, EMMETT AND COMPANY,          Steven A. Kriegsman, an individual
    its agent                             Dated: 9/9/03
                                                 ------

By: /s/ Michael J. Means
   --------------------------------
   Michael J. Means, Vice President

Dated: 9/15/03
       -------

Notice Address:
---------------
808 Wilshire Boulevard, Suite 200
Santa Monica, California 90401<PAGE>
                                                                   Exhibit 10.65

                                AMENDMENT NO. 1
                                       TO
                         CHIEF SCIENTIFIC SPOKESPERSON
                                   AGREEMENT

        This Amendment No. 1 (the "Amendment"), effective as of October 18 ,
2003 (the "Effective Date") is being made to the Agreement between CytRx
Corporation, a Delaware corporation (the "Company") and Dr. Louis J. Ignarro
("Dr. Ignarro"), dated as of July 17, 2003 (the "Agreement").

                                 R E C I T A L S

        WHEREAS, the Company and Dr. Ignarro previously have entered into the
Agreement;

        WHEREAS, Article 4 of the Agreement describes the vesting terms of the
Option (as defined in the Agreement);

        WHEREAS, the Company and Dr. Ignarro each desires to amend the vesting
provisions related to the Option, for the portion of the Option that has not
vested as of the Effective Date;

        NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto, intending to be
legally bound, agree as follows:

1. Amendment to Article 4 -- "Compensation".

        Article 4 of the Agreement is hereby amended and restated, in its
entirety, as follows:

        "4. Compensation. As payment in full for the Services, Dr. Ignarro will
be granted a non-qualified stock option on the Grant Date under the CytRx
Corporation 2000 Long-Tern Incentive Plan to purchase 350,000 registered shares
of the Company's common stock at an exercise price equal to the closing price
for the Company's common stock on Nasdaq on the Grant Date (the "OPTION"). The
Option will have a term of seven years and, from the date hereof until October
17, 2003, will vest monthly at the rate of 4,839 shares for each day of
consulting services provided by Dr. Ignarro in that month and, thereafter, shall
vest monthly at a rate of 15,975 shares for the remaining term of this
Agreement. Any unvested shares under the Option as of the date of termination of
this Agreement shall be cancelled."

2. Continuation of All Other Terms of Agreement.

        Except for the amendment of Article 4, provided for in Article 1 of this
Amendment, all of the terms and conditions of the Agreement shall continue in
full force and effect.

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3. Miscellaneous.

        3.1 Dispute Resolution. The parties agree that any dispute arising out
of or relating to this Amendment shall be resolved solely by means of the
procedures set forth in Article 12 of the Agreement.

        3.2 Counterparts. This Amendment may be executed in one or more
counterparts, each of which shall be deemed an original, and all of which
together shall be deemed to be one and the same instrument.

        3.3 Headings. All headings are for convenience only and shall not affect
the meaning of any provision of this Amendment.

        3.4 Binding Effect. This Amendment shall be binding upon and inure to
the benefit of the parties and their respective permitted successors and
assigns.

        3.5 Amendment. This Amendment may be amended, supplemented, or otherwise
modified only by means of a written instrument signed by all of the parties.

        3.6 Governing Law. This Amendment shall be governed by and construed in
accordance with the laws of the State of California irrespective of any
conflicts of law principles.

        IN WITNESS WHEREOF, the parties have executed this Amendment effective
as of the Effective Date.

CYTRX CORPORATION                        DR. LOUIS J. IGNARRO

By: /s/ Steven A. Kriegsman              /s/ Louis J. Ignarro
   -------------------------------       -------------------------------
   Steven A. Kriegsman
   Chief Executive Officer

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