Document:

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                                                                    EXHIBIT 10.8

NEW ENTERPRISE ASSOCIATES                       2490 Sand Hill Road
                                                Menlo Park, California 94025
                                                Tel: 650.854.9499
                                                Fax: 650.854.9397
                                                www.nea.com

   November 9, 2004

   HIGHLY CONFIDENTIAL
   TO BE READ BY ADDRESSEE ONLY

   Mr. Matthew R. Patterson
   1701 Jackson Street #709
   San Francisco, CA 94109

   Dear Matt:

   It has been a pleasure for all of us to meet and interact with you about
   opportunities with Amicus Therapeutics, and to discuss your role in making it
   a formidable biotechnology company. We are delighted, pending the..outcome of
   reference checks, to convey this offer to join the company as its Executive
   Vice President (EVP) Business Operations, and am confident that you will be
   an outstanding and successful leader in the company. We believe Amices'
   growth potential is tremendous and we sincerely and enthusiastically look
   forward to working with you.

   As we have discussed, you will be part of a team that will provide the
   leadership and strategic direction of Amicus. To that end, you will be
   employed on an "at-will" basis and will be responsible for the following;
   business development, human resources, IT and Facilities, intellectual
   property, business planning and strategy, product launch planning and program
   management. As Amicus succeeds, you will assist in appropriately growing the
   company and delegate various roles to additional executives you help hire.

   It is as exciting time to join Amicus, given the opportunities that the
   company is addressing. In your role, you will report to the CEO. Your
   individual compensation package, as outlined below, includes a variety of
   features which we believe will make your transition easier, both personally
   and professionally. Our overriding interest is to make sure you are intensely
   focused on, and handsomely rewarded for, the company's success.

   THE COMPENSATION PACKAGE

   Your starting salary will be at an annualized rate of Two Hundred arid Fifty
   Thousand Dollars ($250,000), minus customary deductions for federal and state
   taxes and the like, payable on regular company pay days. Your salary level
   will be reviewed annually.

Capital Partners for Entrepreneurs

                1119 St. Paul Street          One Freedom Square
                Baltimore, Maryland 21202     11951 Freedom Drive, Suite 1240
                Tel: 410.244.0115             Reston, VA 20190
                Fax: 410.752.7721             Tel: 703.709.9499
                                              Fax: 703.834.7579

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Mr. Matthew R. Patterson
November 9, 2004
Page 2

throughout your employment with the company during the company's regular
performance review process.

Once you agree to join Amicus, you will receive a sign-on bonus of Twenty-Five
Thousand Dollars ($25,000), minus customary deductions for federal and states
taxes and the like.

In addition, you will be eligible for an annual performance bonus target of
Fifty Thousand Dollars ($50,000), minus customary deductions for federal and
states taxes and the like, payable in cash, based on the achievement of
company-wide and individual performance goals.

You will initially be granted an incentive stock option to purchase One and One
Half Percent (1.50%) of Amicus' current (B Round) fully diluted stock or
[724,101] shares, This option will have an exercise price equal to the current
fair market value of the company's common stock ($0.085) and will vest in the
following manner over the four (4) year period commencing on your start date:
(i) Twenty -five Percent (25%) of this grant will vest after twelve months and
(ii) the balance of the grant will vest ratably over the following thirty six
(36) months, subject to the terms of the Amicus Therapeutics 2002 Equity
Incentive Plan and a written agreement, which will include a right of first
refusal in favor of the company as required by our stockholders agreement, to be
provided by the company. This is a vesting schedule similar to that held by the
rest of the senior management team at the Company.

In addition to the foregoing stock options, you will be eligible to receive
additional stock options to be granted from time-to-time at the discretion of
the Board of Directors.

You will be reimbursed for reasonable relocation expenses up to One Hundred
Thousand Dollars ($100,000) to facilitate your move.

You may also participate in Amicus' standard employee benefits program, which
includes group medical, dental, life and disability insurance as well as a
company sponsored 401k savings and retirement plan, to the extent permissible
under the relevant plans.

If you are terminated without Cause, you will be eligible for a continuation of
six (6) months salary, an additional six (6) months of option vesting, plus
payment of a bonus payment equal to the bonus earned in the preceding year.
"Cause" means for any of the following reasons: (i) willful or deliberate
misconduct by you that materially damages the company; (ii) misappropriation of
company assets; (iii) conviction of or a plea of guilty or "no contest" to, a
felony; or (iv) any willful disobedience of the lawful and unambiguous
instructions of the CEO of the company; provided that the CEO has given you
written notice of such disobedience or neglect and you have failed to cure such
disobedience or neglect within a period reasonable under the circumstances.

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Mr. Matthew R. Patterson
November 9, 2004
Page 3

If there is a Change in Control Event and you resign for Good Reason or are
terminated without Cause within six months of such Change in Control Event, then
(i) you will be entitled to receive a continuation of twelve (12) months salary,
plus payment of a bonus payment equal to the bonus earned in the preceding year
and (ii) all unvested stock options will have their remaining vesting schedule
accelerated so that all stock options are fully vested.

"Change in Control Event" means any of the following: (i) any person or entity
(except for a current stockholder) becomes the beneficial owner of greater than
50% of the then outstanding voting power of the company; (ii) a merger or
consolidation with another entity where the voting securities of the company
outstanding immediately before the transaction constitute less than a majority
of the voting power of the voting securities of the company or the surviving
entity outstanding immediately after the transaction, or (iii) the sale or
disposition of all or substantially all of the company's assets. "Good Reason"
means (i) a change in your position with the company or its successor that
materially reduces your title, duties or level of responsibility; or (ii) the
relocation of the company or its successor greater than 50 miles away from the
then current location of the company's principal offices.

Your right to receive accelerated vesting and severance payments pursuant to the
preceding three paragraphs shall be subject to the condition that you execute a
full release and waiver of all claims against the company and related parties,
in a form acceptable to the company.

You will be required to sign a confidentiality agreement, which includes
provisions relating to confidentiality of certain information, ownership of
inventions, and restrictions on certain activities in order to protect the
company's confidential information, trade secrets and goodwill, and a
non-competition agreement providing that you will not engage in a competitive
business during the term of your employment with the company and for a period of
one year following termination of your employment. Such agreements are signed by
all Amicus employees and consultants.

There is a two (2) year term on this agreement that will automatically renew
unless either party provides a thirty (30) day notice of termination.

This letter constitutes our entire offer regarding the terms and conditions of
your prospective employment with Amicus. It supersedes any prior agreements, or
other promises or statements (whether oral or written) regarding your proposed
employment with the company. The terms of your employment shall be governed by
the law of the State of New Jersey and any disputes shall be resolved in a court
of competent jurisdiction in New Jersey. This offer will expire, if not
accepted, by November 15, 2004. or if you do not commence fulltime employment
with the company within 60 days after such acceptance. We look forward to
receiving your signed acceptance of this offer

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Mr. Matthew R. Patterson
November 9, 2004
Page 4

prior to November 15, with the expectation that you would begin working for
Amicus on December 1, 2004.

Matt, it is may sincere hope that you will accept the role as EVP, Business
Operations of Amicus Therapeutics, and help build it to be the highly successful
company we believe it will be. On behalf of the Board of Directors of Amicus, I
look forward to working with you in your role as EVP, Business Operations of the
company.

                                                With best regards,

                                                /s/ Michael Raab
                                                --------------------------
                                                Michael Raab
                                                Partner
                                                New Enterprise Associates

Agreed to and accepted: /s/ Matthew R. Patterson                 11/15/04
                        -----------------------------            --------
                        Matthew R. Patterson                       Date<PAGE>
                                                                   Exhibit 10.9

[AMICUS THERAPEUTICS LOGO]

July 27, 2006

Mr. James Dentzer
304 Goodmans Hill Road
Sudbury, MA 01776

Dear Jim:

     On behalf of Amicus Therapeutics, Inc. (the "Company"), I am pleased to
confirm our offer to you for the position of Chief Financial Officer reporting
to me. Your start date will be mutually agreed upon but no later than October 2,
2006.

     Prior to the commencement of your employment you will be required to
execute the Company's Confidentiality, Disclosure and Non-Competition Agreement.
A copy of this agreement is attached. In addition, as a condition of employment
Amicus requires a pre-employment drug screening.

     In consideration for all your services to be rendered to the Company your
annual base salary will be $280,000, to be paid bi-weekly in accordance with the
Company's payroll practices. Upon the completion of mutually agreed upon
individual goals and objectives as well as the achievement of specific Company
goals, you will be eligible to receive a year end bonus target of 30% of your
base salary. Once you agree to join Amicus, payable with your first paycheck,
you will receive a sign on bonus of $100,000 minus customary deductions.

     Upon approval by the Board of Directors you will receive 300,000 shares of
restricted stock. These shares will vest over a four-year period as follows: 25%
on the first anniversary of the date of grant, and the remaining 75% in equal
monthly increments thereafter. In addition and also upon approval by the Board
of Directors, you will receive an incentive stock option to purchase 250,000
shares of the Company's common stock, par value $.01 per share (the "Common
Stock") pursuant to a stock option agreement in form and substance acceptable to
the Company. The options will become exercisable over a four-year period as
follows: 25% on the first anniversary of the date of grant, and the remaining
75% in equal monthly increments thereafter. The exercise price of the options
will be the fair market value of the Company's common stock on the date of
grant. Shares issuable upon exercise of each option will be subject to certain
transfer restrictions including the right of first refusal. Additionally,
exercise of the options will be governed in accordance with the provisions of
the Company's stock option plan.

     You will be eligible to participate in the Company's health benefits
program and are eligible to participate in the Company's 401(k) as well as any
other employee benefit plan(s) that are generally made available by the Company
to its employees from time to time when and as the Company may make them
available.
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James Dentzer
July 27, 2006
Page #2 of 3

     You will be eligible for paid Company holidays as outlined in our Holiday
Policy and you will be eligible for twenty (20) days paid vacation, three weeks
during the year and one between Christmas and New Years. Vacation accrues on a
monthly basis. Because the Company expects to regularly review its benefit
programs to keep them up to date and competitive, these programs are subject to
periodic adjustments so that certain features may be added, modified or deleted
over time.

     Given that you currently reside over 50 miles from our location in
Cranbury NJ, you will be eligible to receive our "Homeowners Relocation
Program". The details of which are enclosed. You must complete your entire move
within 12 months of your date of hire. Should you voluntarily resign your
employment within 12 months of your date of hire you will owe the company the
appropriate prorated portion of this relocation.

     If you are terminated without Cause, you will be eligible for a
continuation of six (6) months salary, an additional six (6) months of option
vesting, plus payment of a bonus payment equal to the bonus earned in the
preceding year. "Cause" means for any of the following reasons: (i) willful or
deliberate misconduct by you that materially damages the company; (ii)
misappropriation of company assets; (iii) conviction of or a plea of guilty or
"no contest" to, a felony; or (iv) any willful disobedience of the lawful and
unambiguous instructions of the CEO of the company; provided that the CEO has
given you written notice of such disobedience or neglect and you have failed to
cure such disobedience or neglect within a period reasonable under the
circumstances.

     If there is a Change in Control Event and you resign for Good Reason or
are terminated without Cause within six months of such Change in Control Event,
then (i) you will be entitled to receive a continuation of twelve (12) months
salary, plus payment of a bonus payment equal to the bonus earned in the
preceding year and (ii) all unvested equity-based compensation will have their
remaining vesting schedule accelerated so that all unvested equity-based
compensation are fully vested.

     "Change in Control Event" means any of the following: (i) any person or
entity (except for a current stockholder) becomes the beneficial owner of
greater than 50% of the then outstanding voting power of the company; (ii) a
merger or consolidation with another entity where the voting securities of the
company outstanding immediately before the transaction constitute less than a
majority of the voting power of the voting securities of the company or the
surviving entity outstanding immediately after the transaction, or (iii) the
sales or disposition of all or substantially all of the company's assets. "Good
Reason" means (i) a change in your position with the company or it successor
that materially reduces your title, duties or level of responsibility; or (ii)
the relocation of the company or its successor greater than 50 miles away from
the then current location of the company's principal offices.

     Your right to receive accelerated vesting and severance payments pursuant
to the preceding three paragraphs shall be subject to the condition that you
execute a full release and waiver of all claims against the company and
related parties, in a form acceptable to
<PAGE>
James Dentzer
July 27, 2006
Page #3 of 3

     There is a two (2) year term on this agreement that will automatically
renew unless either party provides a thirty (30) day notice of termination.

     In accordance with the Immigration and Naturalization Control Act, all new
employees must provide documentation that they have the legal right to work in
the United States. A copy of Form I-9 and a list of the acceptable documents
confirming your right to work in the United States are also attached for your
convenience.

     To indicate your acceptance of our offer, please sign one copy of this
letter in the space indicated below and return it to the attention of Nicole
Schaeffer, Vice President of Human Resources & Leadership Development by August
11, 2006. Acceptance of this offer constitutes your agreement with all of the
above terms and conditions of employment with Amicus Therapeutics, Inc., and
constitutes agreement to conform to Amicus Therapeutics, Inc. rules and
procedures. By signing below, you agree that no other promises, express or
implied, have been made to you either verbally or in writing and that no
further modifications to these terms and conditions will be effective except by
a written agreement signed by the Chief Executive Officer of the Company and
you.

     The formality of this letter not withstanding, I extend my personal best
wishes and sincere pleasure that you are joining our team. I look forward to
working with you.

Sincerely,

/s/ John F. Crowley
John F. Crowley
President & CEO

I accept the offer of employment under the terms and conditions stated above.
No other promises, express or implied, have been made to me either verbally or
in writing.

By: /s/ James Dentzer                  Date:   8/15/06
   ------------------------                 ------------------------
        James Dentzer

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