Document:

Fang consultant agreement

 Exhibit 10.16 
  
 AVICENA 
 228 Hamilton Avenue, 3rd Floor 
 Palo Alto, CA 94301 
 Tel: 415-397-2880 
 Fax: 415-397-2898 
  
 February 25, 2005 
  
 Leslie Fang, MD, Ph.D 
  
 Dear Leslie: 
  
 The purpose of
this letter is to confirm the terms by which you shall continue to be serve as a consultant to Avicena Group, Inc. (the “Company”). Key points are as follows. 
  
 Position: You will serve as the Chairman of the Company’s Scientific Advisory Board and as the Chief Scientific Officer of the
Company and perform such other services as mutually agreed to by you and the Company from time to time. 
  
 Restricted Stock: In consideration for your services, effective February 9, 2005, you were granted 357,143 restricted shares of the Company’s common stock. The shares were granted pursuant to, and subject
to, the Company’s 1999 Stock Incentive Plan (the “Plan”). The definitive terms of the grant are governed by the Plan and the Restricted Stock Purchase Agreement executed between you and the Company. 
  
 Status: As an independent contractor, you shall not participate in any employee
benefit plan or program or be subject to any employment rules, regulations or policies of the Company. You shall have control over the method of performance of your duties hereunder and shall independently manage and control your activities subject
only to the terms of this agreement. You recognize, acknowledge and agree that, as an independent contractor, all income paid to you under this letter agreement shall constitute income from self-employment and you shall be required to pay
self-employment taxes pursuant to Section 1401 of the Internal Revenue Code of 1986, as amended. You agree to fully defend and indemnify the Company and its shareholders, subsidiaries, affiliates, officers, directors, and employees against and will
hold the Company, its shareholders, subsidiaries, affiliates, officers, directors, and employees harmless from any and all claims, costs, damages, demands, expenses (including without limitation attorneys’ fees), or other liabilities of any
kind or nature whatsoever arising from or related to your breach or failure to comply with your tax obligations under this provision. 
  
 Relationship: The terms of this letter agreement do not modify the at-will status of your relationship with the Company. It is expressly understood, therefore,
that the Company and you are free to terminate your services at any time. No employee of the Company, other than Nasser Menhall, has the authority to alter, orally or in writing, the terms of the at-will status of your relationship. 
  
 No Other Understandings: This letter sets forth our entire agreement and understanding
and supersedes any and all other agreements, either oral or in writing (including, but not limited to, 

  
 Ms. Leslie Fang, MD, Ph.D 
 February 25, 2005 
 Page 2 
  
 any agreement and/or understanding pertaining to equity ownership in the Company), between
the Company, any of its shareholders, members, and/or principals and you with respect to your compensation as a consultant. No change to this letter will be valid unless in writing and signed by the Company and you. 
  
 Governing Law: This offer letter will be governed by and construed in accordance with
the internal laws of the State of Delaware. 
  
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK] 

  
 Ms. Leslie Fang, MD, Ph.D 
 February 25, 2005 
 Page 3 
  
 Please confirm your acceptance of the terms of this letter agreement by signing on the space
provided below and returning this letter to the Company. 
  

	
	
	 /s/ Belinda Tsao Nivaggioli

	 Belinda Tsao Nivaggioli

  

	
	 Accepted this 25th day of

	 February, 2005.

	
	 /s/ Leslie Fang

	 Leslie Fang, MD, Ph.DNasser Series C Subscription Agreement

 Exhibit 10.17 
  
 Subscription Agreement 
 for Placement of Avicena Group, Inc. Units 
  
 By its execution and
delivery of this subscription agreement, the undersigned Subscriber hereby joins in and agrees to purchase the aggregate number of Units set forth below: 
  

					
	    102,000    	  	Units, each consisting on One Share of Series C Preferred Stock and one Warrant (exercisable for $0.01 to purchase One additional Share of Common Stock) at $1.00 per Unit, for an aggregate
purchase price of:	    	$102,000    

  

					
			
	/s/ Nasser Menhall	 	 	 	August 15, 2004
	Signature	 	 	 	Date

  
 Nasser Menhall

 Investor or Investing Entity Name 
  

					
	 C/o World Care One Cambridge Ctr.
 Cambridge, MA
02142
	  	(617) 250-5161	  	 __________________________

	Investor’s Address	  	Telephone	  	Fax

  

					
	 Please wire your subscription to:
 Sachnoff & Weaver, Ltd.
 Client Escrow Account

	 		 
	ACCOUNT NAME:	  	 Sachnoff & Weaver Ltd.
	  	 
	 ACCOUNT NUMBER:
 BANK NAME:
 ABA ROUTING NUMBER:
	  	 1894668
 Northern Trust Bank
 071000152
	  	 
	REMARKS:	  	 Avicena Private Placement
	  	 
	 		 
	Note:	  	 Call Gail Carone at (312) 651-1515
	  	 

  
 Please indicate the name of the
investor or investing entity on the wire transfer so that we may more easily identify the transferor. Funds should be wired in US Dollars. In addition, please note that the wire transfer fees may be taken out of the funds that are wired and that
sufficient funds should be wired to cover these fees. This form should be telefaxed to the following with the original to follow by mail. 
  

					
	 Ms. Gail Carone
 Fax: 312-207-6400
  

			
	 Agreed and accepted to as to
 102,000 Units at $1.00 per share:
  
 AVICENA GROUP, INC.

		
	 By:
	 	 /s/ Nasser Menhall

	 Name:
	 	 Nasser Menhall

	 Title:
	 	 President

		
	 Date:
	 	 August 15, 2004AVN Note to K Georgiou

 Exhibit 10.18 
  
 NOTE 
  
 US$250,000 
  
 Buffalo, New York 
  
 January     , 2005 
  
 FOR VALUE RECEIVED, the undersigned, AVN ACQUISITION CORP., having an address of 497 Delaware Avenue, Buffalo, New York 14202 (the “Borrower”), hereby promises to pay to the order of Karen
Georgiou, having an address of 10150 Pineview Trail Campbellville, Ontario, L0P 1B0 (the “Lender”), the principal sum of Two Hundred Fifty Thousand Dollars ($250,000) (All monetary amounts herein are expressed in U.S. Dollars).
Principal on this Note shall be payable on May 31, 2006 or such earlier date as (i) the Borrower shall complete its proposed merger with Avicena Group, Inc. (“Avicena”) or (ii) Avicena shall have repaid a certain loan of even date herewith
made by Borrower to Avicena. Interest on the outstanding principal amount shall accrue at the rate of eight percent (8%) per annum, payable on December 31 for so long as this Note shall remain outstanding and at Maturity. 
  
 The Borrower shall have the option of prepaying the unpaid portion of such
principal sum in full or part at any time or from time to time without any premium or penalty, provided that upon prepaying such unpaid portion in full the Borrower shall pay to the Lender all interest and other amounts owing pursuant to this Note
but not yet paid. 
  
 All amounts owing pursuant to this Note but
not yet paid shall, without any notice, demand, presentment or protest of any kind, automatically become immediately due if the Borrower commences or has commenced against it any bankruptcy or insolvency proceeding. All amounts owing pursuant to
this Note but not yet paid shall, without any notice, demand, presentment or protest of any kind, become immediately due at the sole option of the Lender if (1) any amount owing pursuant to this Note is not paid when due, (2) the Borrower is
dissolved, or becomes insolvent (however such insolvency is evidenced), or (3) there occurs or exists any material event or condition of default for purposes of any security agreement, mortgage or other agreement now or hereafter in effect between
the Lender and the Borrower. 
  
 All payments under this Note are
to be made to the Lender at the Lender’s address referenced above or at such other address as the Lender may from time to time designate in writing. 
  
 The Borrower promises to pay reasonable costs and expenses incurred by the Lender in collecting this Note and enforcing the Lender’s rights
hereunder, including, but not limited to, the reasonable fees and disbursements of legal counsel to the Lender. 
  
 Failure or delay by the Lender in exercising, or a single or partial exercise of, any power or right hereunder shall not operate as a waiver thereof or of
any other power or right or preclude any other future exercise of that or any other power or right. A waiver of any power or right hereunder shall be in writing, shall be limited to the specific instance and shall not be deemed a waiver of the
subject power or right in the future or a waiver of any other power or right. 

 This Note may not be modified or terminated orally or by any course of conduct but only by an agreement
in writing duly executed by the Borrower and the Lender. 
  
 This
Note shall be governed by and construed, interpreted and enforced in accordance with the internal law of the State of New York, without regard to principles of conflict of laws. 
  

			
	 AVN ACQUISITION CORP.

		
	 By:
	 	 /s/ Andrew Gertler

	 Andrew Gertler, President

  

 2Fang's Restricted Stock Agreement

 Exhibit 10.19 
  
 RESTRICTED STOCK PURCHASE AGREEMENT 
  
 THIS RESTRICTED STOCK PURCHASE AGREEMENT (this “Agreement”) is made as of February 9, 2005, between
Avicena Group, Inc., a Delaware corporation (the “Company”), and Leslie Fang (“Recipient”). 
  
 The Company and Recipient desire to enter into an agreement pursuant to which Recipient will be granted, an aggregate of 357,143 shares of the
Company’s Common Stock (the “Common Stock”), under the Company’s 1999 Stock Incentive Plan (the “Plan”). All of such shares of Common Stock are referred to herein as “Recipient Shares” or
the “Shares.” Recipient Shares will also include shares of the Company’s capital stock or other securities of the Company issued with respect to Recipient Shares by way of a stock split, dividend or other recapitalization or
reclassification. Certain definitions are set forth in Section 10 of this Agreement. Any terms used herein, if not otherwise defined, shall have the same meaning as in the Plan. 
  
 The parties hereto agree as follows: 
  
 1. Recipient Shares. 
  
 (a) Upon execution of this Agreement, Recipient will be granted 357,143 shares of Common Stock. The purchase price for such Shares will be deemed to be
zero. The Secretary of the Company shall hold the certificate representing the Recipient Shares, properly endorsed for transfer, until such time as Recipient fulfills the service requirements of Section 2. 
  
 (b) Within thirty (30) days after the grant to the Recipient of Recipient
Shares pursuant to this Agreement, Recipient will make an effective election with the Internal Revenue Service under Section 83(b) of the Internal Revenue Code and the regulations promulgated thereunder in the form of Exhibit A attached
hereto. 
  
 (c) In connection with the grant of the Recipient
Shares pursuant hereto, Recipient represents and warrants to the Company that: 
  
 (i) The Recipient Shares to be acquired by Recipient pursuant to this Agreement will be acquired for Recipient’s own account and not
with a view to, or intention of, distribution thereof in violation of the Securities Act, or any applicable state securities laws, and the Recipient Shares will not be disposed of in contravention of the Securities Act or any applicable state
securities laws; 
  
 (ii) Recipient is a key
service provider of the Company, is sophisticated in financial matters and is able to evaluate the risks and benefits of the investment in the Recipient Shares; 
  
 (iii) Recipient is aware that the investment in the Company is a speculative investment which has limited
liquidity and is subject to the risk of complete loss. Recipient is able to bear the economic risk of his or her investment 

 
in the Recipient Shares for an indefinite period of time because the Recipient Shares have not been registered under the Securities Act and, therefore,
cannot be sold unless subsequently registered under the Securities Act or an exemption from such registration is available; 
  
 (iv) Recipient has had an opportunity to ask questions and receive answers concerning the terms and conditions of the offering of the
Recipient Shares and has had full access to such other information concerning the Company as he or she has requested; 
  
 (v) Recipient has the full right, power and authority to execute and deliver this Agreement, and to perform his or her obligations
hereunder. This Agreement constitutes the valid and legally binding obligations of the Recipient enforceable against him or her in accordance with its terms, except as the same may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium or other laws relating to or affecting the enforcement of creditors’ rights generally, now or hereafter in effect and subject to the application of equitable principles and the availability of equitable remedies, and the execution,
delivery and performance of this Agreement by Recipient does not and will not conflict with, violate or cause a breach of any agreement, contract or instrument to which Recipient is a party or any judgment, order or decree to which Recipient is
subject; 
  
 (vi) In connection with any
underwritten public offering by the Company of its equity securities pursuant to an effective registration statement filed under the Securities Act (a “Public Offering”), the Recipient agrees that he or she shall not, directly or
indirectly, sell, make any short sale of, loan, hypothecate, pledge, offer, grant or sell any option or other contract for the purchase of, purchase any option or other contract for the sale of, or otherwise dispose of or transfer, or agree to
engage in any of the foregoing transactions with respect to, any Recipient Shares acquired hereunder without the prior written consent of the Company or its underwriters. Such restriction (the “Market Stand-Off”) shall be in effect
for such period of time following the date of the final prospectus for the offering as may be requested by the Company or such underwriters but in no event longer than 365 days. Recipient further agrees to execute any agreement reflecting such
Market Stand-Off, as may be requested by the Company or such underwriters. In order to enforce the Market Stand-Off, the Company may impose stop-transfer instructions with respect to the Recipient Shares until the end of the applicable standoff
period. The Company’s underwriters shall be beneficiaries of this Agreement; 
  
 (vii) Recipient is not a party to or bound by any employment agreement, noncompete agreement or confidentiality agreement which conflicts
with the obligations set forth in this Agreement; and 
  
 (viii) Recipient is a resident of the State of                     . 

 (d) As an inducement for the Company to commit to issue the Recipient Shares to Recipient, and as a
condition thereto, Recipient acknowledges and agrees that neither any future issuance of capital stock of the Company to Recipient nor any provision contained herein shall entitle Recipient to remain in the service of the Company, or any affiliate
of the Company, or affect the right of the Company or any of its affiliates to terminate Recipient’s service at any time for any reason. 
  
 2. Vesting of Shares. 
  
 (a) The Recipient Shares purchased hereunder will become vested as follows: fifty percent (50%) of the Recipient Shares shall become vested on the first
anniversary of this Agreement, and an additional twenty-five percent (25%) of the Recipient Shares shall become vested on each of the second and third anniversaries of this Agreement, so long as the Recipient continues to provide services for the
Company on each such vesting date. Upon the termination of the Recipient’s services for any or no reason, all vesting of the Recipient Shares shall cease. The foregoing notwithstanding, if the Recipient’s services are terminated by the
Company without Due Cause, then all Unvested Shares shall become Vested Shares as of the date of such termination. 
  
 (b) Recipient Shares which have become vested hereunder are referred to herein as “Vested Shares,” and all other Recipient Shares are
referred to herein as “Unvested Shares.” 
  
 (c)
The Recipient Shares shall at all times be subject to such restrictions or limitations with respect to the Transfer thereof that may be contained herein or as otherwise provided by law. 
  
 (d) Recipient shall have the right to vote the Recipient Shares and to receive dividends and other distributions thereon
unless and until, the Unvested Shares are forfeited pursuant to Section 2(a) hereof; provided, however, that a dividend or other distribution with respect to Unvested Shares (including, without limitation, a stock dividend or stock split),
other than a regular cash dividend, shall be delivered to the Company (and the Recipient shall, if requested by the Company, execute and return one or more irrevocable stock powers related thereto) and shall be subject to the same restrictions as
the Unvested Shares with respect to which such dividend or other distribution was made. 
  
 3. Repurchase Option. 
  
 (a) Except as set forth in Section 2(a), in the event Recipient ceases to be engaged by or provide services for the Company or any of its affiliates for any reason (a “Separation”), all Unvested Shares will be
forfeited and the Vested Shares (whether held by Recipient or one or more of Recipient’s transferees as permitted hereunder) will be subject to repurchase, in each case by the Company pursuant to the terms and conditions set forth in this
Section 3 (the “Repurchase Option”). 

 (b) In the event of a Separation, the Vested Shares acquired hereunder shall be subject to repurchase at
a purchase price equal to the Fair Market Value for each such share. 
  
 (c) In the event of a Separation, the Company may elect to purchase all or any portion of the Vested Shares by delivering written notice (the “Repurchase Notice”) to the holder or holders of such Shares within 60 days after
the Separation. The Repurchase Notice will set forth the number of Vested Shares to be acquired from each holder, the aggregate consideration to be paid for such securities and the time and place for the closing of the transaction. The number of
securities to be repurchased by the Company shall first be satisfied to the extent possible from the Shares held by Recipient at the time of delivery of the Repurchase Notice. If the number of Shares then held by Recipient is less than the total
number of such securities which the Company has elected to purchase, the Company shall purchase the remaining securities elected to be purchased from the other holder(s) of the Shares under this Agreement, pro rata according to the number of the
Shares held by such other holder(s) at the time of delivery of such Repurchase Notice (determined as nearly as practicable to the nearest share). The number of Vested Shares to be repurchased hereunder will be allocated among the Recipient and the
other holders of the Shares (if any) pro rata according to the number of the Shares to be purchased from such Person. 
  
 (d) Notwithstanding anything to the contrary contained in this Agreement, all repurchases of Shares by the Company shall be subject to applicable
restrictions contained in the Delaware General Corporation Law and as may be required by other parties in the Company’s equity financing agreements and agreements evidencing indebtedness for borrowed money, if any. If any such restrictions
prohibit the repurchase of Shares hereunder which the Company is otherwise entitled or required to make, the Company may make such repurchases as soon as it is permitted to do so under such restrictions. 
  
 (e) Notwithstanding anything to the contrary contained in this Agreement, if
Recipient delivers the notice of objection described in the definition of Fair Market Value, or if the Fair Market Value of a Share is otherwise determined to be an amount more than 10% greater than the per share repurchase price for such Shares
originally determined by the Board of Directors, the Company shall have the right to revoke its exercise of the Repurchase Option for all or any portion of the Shares elected to be repurchased by it by delivering notice of such revocation in writing
to the holders of the Shares during (i) the thirty-day period beginning on the date the Company receives Recipient’s written notice of objection and (ii) the thirty-day period beginning on the date the Company is given written notice that the
Fair Market Value of a Share was finally determined to be an amount more than 10% greater than the per share repurchase price for such Shares originally determined by the Board. 
  
 4. Purchase of Shares - Right of First Refusal. 
  
 (a) If the Company does not exercise its option to purchase the Vested Shares of the Recipient upon the Recipient’s
Separation, and if the Recipient or other holder of 

 
such Shares subsequently desires following Separation to transfer all or any portion of his or her Shares to any person or entity, and receives a bona fide
offer to purchase the same (the “Offered Shares”), the Recipient shall give at least sixty (60) days’ prior written notice (the “Offer Notice”) to the Company of his or her intention to so transfer the Shares.
The Offer Notice shall state (1) the number of Offered Shares; (2) the name, business, and residence address of the proposed transferee; (3) whether or not the transfer is for valuable consideration and, if so, the consideration (the
“Offered Price”); (4) the date upon which the proposed transfer to the transferee is to be consummated; and (5) all other material terms and conditions of the proposed transfer. A copy of any written agreement between the Recipient
or other holder of the Shares and the transferee (whether executed or not) shall be attached to the Offer Notice. 
  
 (b) From and after the date of the Offer Notice, the Company shall have the option, but no obligation, to purchase the Offered Shares (the
“Call”) at the lesser of the Offered Price or the Fair Market Value of the Offered Shares, and upon the same terms and conditions provided in the Offer Notice, exercisable in the order of priority and within the time periods set
forth below: 
  
 (i) Within forty-five (45) days
after the date of the Offer Notice (or until the date the Fair Market Value is determined, if later), the Company shall have the option, but no obligation, to acquire all of the Offered Shares. The Company shall exercise the Call, if at all, by
giving written notice to that effect to the Recipient or other holder of the Shares within such forty-five (45) day option period or, if later, within fifteen (15) days of the determination of Fair Market Value. The exercise of the Company’s
option must, in the aggregate, include the purchase of all of the Offered Shares or the exercise of such option shall be null and void. 
  
 (ii) If the Company fails to exercise its Call to purchase in the aggregate all of the Offered Shares, the Offered Shares may be
transferred to the transferee identified in the Offer Notice during the thirty (30) days following the date of the proposed transfer, as set forth in the Offer Notice, at the same exact price and on the same exact terms and conditions set forth in
the Offer Notice. The effectiveness of such transfer is conditioned upon the transferee agreeing in writing to be a party to this Agreement and to be bound by all of its terms, conditions, and provisions. If the transfer does not occur in accordance
with the terms disclosed in the Offer Notice, such transfer shall be automatically null and void without any further action being required on the part of the Company, and any attempt to transfer the Offered Shares thereafter without first complying
with the terms of this Agreement shall be deemed null and void. 
  
 5. Closing of Repurchase. 
  
 (a) The closing of
any Repurchase Option exercised by the Company pursuant to Section 3 of this Agreement, or any Call exercised by the Company pursuant to Section 4 of this Agreement, shall take place at the offices of the Company on a date not more
than thirty (30) days after the delivery of the Repurchase Notice or exercise of the Call (the 

 
“Closing Date”). At the Closing Date, the Company shall be entitled to receive customary representations and warranties from the Recipient
or other holder of the Shares regarding the sale of the Shares, and the Recipient or other holder of the Shares will deliver all stock certificates representing the Shares to be purchased, endorsed for transfer to the Company, or accompanied by an
Assignment Separate from Certificate in favor of the Company. 
  
 (b) The Company shall deliver a certified or bank cashier’s check, or wire transfer, in the amount of the aggregate purchase price for such Shares or, if the Company so chooses, by a subordinate note or notes payable in three
substantially equal annual installments beginning on the six month anniversary of the closing of such purchase and bearing interest (payable quarterly) at a rate per annum equal to the prime rate as published in The Wall Street Journal from time to
time. 
  
 (c) Notwithstanding anything herein to the contrary, the
Company shall not be obligated to make any payment pursuant to this Section 5 if such payment would constitute a violation of applicable law or any covenant of any loan document or similar or other agreement with banks, insurance companies,
investors, or third parties by which the Company is bound. In the event the restrictions and exceptions provided herein come into being, the Company shall use reasonable efforts to cause such covenants restricting such repurchase to be waived or
modified, if possible, to the extent necessary to permit such repurchase to be made; provided that the Company shall not be obligated hereunder to make any payments to any third parties in order to obtain such waivers or modifications. In the event
the restrictions and exceptions provided herein come into being, the Company shall pay such portion of the applicable payment as it is then able to pay pursuant to the terms hereof, that would not be so restricted, excepted or prohibited. The
remainder of such amount shall be paid at such time as said conditions no longer exist; provided that interest shall be paid on any unpaid amounts hereunder at a borrowing rate equal to the applicable mid-term federal rate in effect on the date the
payment of such amount would otherwise become due hereunder. 
  
 6. Sale of the Company. 
  
 (a) In the event of an
Acquisition Event, the Recipient agrees to vote the Recipient Shares in favor of the Acquisition Event and, if the Acquisition Event is a sale of the Company’s capital stock, will agree to sell his Recipient Shares on the terms and conditions
approved by the Company’s Board. The Recipient will not exercise any statutory dissenters’ right with regard to an Acquisition Event and will take all necessary and desirable actions in connection with the consummation of the Acquisition
Event. Acquisition Event shall have the meaning ascribed to it under the Plan and shall further include any transaction or series of transactions pursuant to which (A) any Person(s) other than the Company and its affiliates in the aggregate
acquire(s) (i) capital stock of the Company possessing the voting power (other than voting rights accruing only in the event of a default, breach or event of noncompliance) to elect a majority of the Company’s board of directors (whether by
merger, consolidation, reorganization, combination, sale or transfer of the Company’s capital stock, shareholder or voting 

 
agreement, proxy, power of attorney or otherwise) or (ii) all or substantially all of the Company’s assets determined on a consolidated basis.

  
 (b) Notwithstanding Section 6(a), the right of the
Company to consummate any Acquisition Event structured as a sale of stock is subject to the satisfaction of the conditions that upon the consummation of the Acquisition Event, the Recipient will receive the same form and amount of consideration for
the Vested Shares as any other shareholder, or if other shareholders are given an option as to the form and amount of consideration to be received, the Recipient will be given the same option. The Unvested Shares, if any, shall, as determined in the
sole discretion of the Company, either continue to vest pursuant to the terms of Section 2 of this Agreement, be forfeited or become fully vested immediately prior to the Acquisition Event. 
  
 (c) If the Company or any shareholders of the Company enter into any
negotiation or transaction for which Rule 506 (or any similar rule then in effect) under the Securities Act may be available with respect to such negotiation or transaction (including a merger, consolidation or other reorganization), the Recipient
will, to the extent required to comply with Rule 506, appoint a purchaser representative (as such term is defined in Rule 501 under the Securities Act) reasonably acceptable to the Company. If the Recipient appoints the purchaser representative
designated by the Company, the Company will pay the fees of such purchaser representative and if the Recipient declines to appoint the purchaser representative designated by the Company, the Recipient will appoint another purchaser representative
(reasonably acceptable to the Company) and the Recipient will be responsible for the fees of the purchaser representative so appointed. 
  
 (d) The Recipient will bear his or her pro rata share (based upon the number of shares of Common Stock sold in an Acquisition Event) of the costs of such
Acquisition Event to the extent such costs are not otherwise paid by the Company or the acquiring party. Costs incurred by the Recipient and on his behalf will not be considered costs of the transaction. 
  
 7. Restrictions on Transfer of Recipient Shares. 
  
 (a) Transfer of Recipient Shares. Except as otherwise set forth in
Sections 3, 4 and 6, the Recipient shall not sell, transfer, convey, exchange, give, assign or pledge all or any part of the Shares owned by him or her or any securities convertible into or exchangeable for the Shares, whether
now owned or later acquired, to any Person (other than to the Recipient’s spouse and descendants or any trust established solely for the benefit of the Recipient and/or the Recipient’s spouse and/or descendants (“Permitted
Transferees”)), provided that all such Permitted Transferees first agree in writing to comply with the terms and provisions hereof. Recipient may not sell, transfer, convey, exchange, give, assign or pledge all or any part of the Shares
while a service provider of the Company, except to a Permitted Transferee or as otherwise allowed under Section 6. Any attempted transfer not perfected in accordance with this Agreement shall be void and shall not transfer ownership in, title
to, or any rights respecting the Shares. 

 (b) Termination of Restrictions. With respect to Vested Shares only, any restrictions and
obligations of such Shares set forth in this Agreement will terminate upon a Qualified Public Offering of the Company. 
  
 8. Registration. Recipient understands that the Shares are not currently being registered under the Securities Act by reason of their contemplated
issuance in a transaction exempt from the registration and prospectus delivery requirements of the Securities Act pursuant to Rule 701 thereof. Recipient further agrees that he or she will not sell or otherwise dispose of the Shares unless such sale
or other disposition has been registered or is exempt from registration under the Securities Act and has been registered or qualified or is exempt from registration or qualification under applicable securities laws of any state. Recipient
understands that a restrictive legend consistent with the foregoing, and as set forth in Section 9, will be placed on the certificates evidencing the Shares, and related stop transfer instructions will be noted in the stock transfer records
of the Company and/or its stock transfer agent for the Shares. 
  
 9. Additional Restrictions on Transfer of Recipient Shares. 
  
 (a) Legend. The certificates representing the Recipient Shares will bear a legend in substantially the following form: 
  

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE WERE ORIGINALLY ISSUED AS OF FEBRUARY 9, 2005, HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “ACT”), AND MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT OR AN EXEMPTION FROM REGISTRATION THEREUNDER. THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE ALSO
SUBJECT TO ADDITIONAL RESTRICTIONS ON TRANSFER, CERTAIN REPURCHASE OPTIONS AND CERTAIN OTHER AGREEMENTS SET FORTH IN A RESTRICTED STOCK PURCHASE AGREEMENT BETWEEN THE COMPANY AND A SERVICE PROVIDER OF THE COMPANY DATED AS OF FEBRUARY 9, 2005. A COPY
OF SUCH AGREEMENT MAY BE OBTAINED BY THE HOLDER HEREOF AT THE COMPANY’S PRINCIPAL PLACE OF BUSINESS WITHOUT CHARGE.” 
  
 (b) Opinion of Counsel. No holder of Recipient Shares may transfer any Recipient Shares (except pursuant to an effective registration statement
under the Securities Act) without first delivering to the Company an opinion of counsel (reasonably acceptable in form and substance to the Company) that neither registration nor qualification under the Securities Act and applicable state securities
laws is required in connection with such Transfer. 

 10. Definitions. 
  
 “Due Cause” means (i) Recipient’s breach of any of Recipient’s obligations under any
confidentiality, inventions and non-solicitation agreement or this Agreement; (ii) Recipient’s neglect of, willful misconduct in connection with the performance of, or refusal to perform his duties on behalf of the Company, which, in the case
of neglect or refusal to perform, has not been cured to the Company’s good faith satisfaction within thirty (30) days after Recipient has been provided notice of the same; (iii) Recipient’s engagement in any conduct which injures the
integrity, character or reputation of the Company; or (iv) the Recipient’s commission of an act or acts constituting a felony, or other act involving dishonesty, disloyalty or fraud against the Company. 
  
 “Fair Market Value” of each Recipient Share as of a relevant
date means the average of the closing prices of the sales of the Recipient Shares on all securities exchanges on which such securities may at the time be listed on that date, or, if there have been no sales or exchange on which the security is
listed on any day, the average of the highest bid and lowest asked prices on all nationally-recognized exchanges at the end of such day, or, if on any day such security is not so listed, the average of the representative bid and asked prices quoted
in the NASDAQ System as of 4:00 P.M., New York time, or, if on any day such security is not quoted in the NASDAQ System, of the average of the highest bid and lowest asked prices on such day in the domestic over-the-counter market as reported by the
National Quotation Bureau Incorporated, or any similar successor organization, in each such case averaged over a period of 21 days consisting of the day as of which the Fair Market Value is being determined and the 20 consecutive business days prior
to such day. If at any time such Recipient Shares is not listed on any securities exchange or quoted in the NASDAQ System or the over-the-counter market, the Fair Market Value will be the fair value of such security determined in good faith by the
Board of Directors of the Company (the “Board Calculation”). If the Recipient disagrees with the Board Calculation, the Recipient may, within 30 days after receipt of the Board Calculation, deliver a notice (an “Objection
Notice”) to the Company setting forth the Recipient’s calculation of Fair Market Value. The Board and the Recipient will negotiate in good faith to agree on such Fair Market Value, but if such agreement is not reached within 30 days
after the Company has received the Objection Notice, Fair Market Value shall be determined by an appraiser selected by the Board, which appraiser shall submit to the Board and the Recipient a report within 30 days of its engagement setting forth
such determination. The determination of such appraiser shall be final and binding upon all parties. The expenses of such appraiser shall be borne by the Recipient unless the appraiser’s valuation is more than 10% greater than the amount
determined by the Board of Directors, in which case, the costs of the appraiser shall be borne by the Company. If the Repurchase Option is exercised within 45 days after a Separation, then Fair Market Value shall be determined as of the date of such
Separation; thereafter, Fair Market Value shall be determined as of the date the Repurchase Option is exercised. 
  
 “Person” means an individual, a partnership, a limited liability company, a corporation, an association, a joint stock company, a trust,
a joint venture, an unincorporated organization and a governmental entity or any department, agency or political subdivision thereof. 

 “Public Sale” means any sale pursuant to a registered public offering under the
Securities Act or any sale to the public pursuant to Rule 144 promulgated under the Securities Act effected through a broker, dealer or market maker. 
  
 “Qualified Public Offering” means the sale in an underwritten public offering registered under the Securities Act of shares of the
Company’s Common Stock with minimum net proceeds of Three Million Dollars ($3,000,000). 
  
 “Recipient’s Family Group” means Recipient’s spouse and descendants (whether natural or adopted), any trust solely for the benefit of Recipient and/or Recipient’s spouse and/or
descendants and any retirement plan for the Recipient. 
  
 “Securities Act” means the Securities Act of 1933, as amended from time to time. 
  
 “Transfer” means to sell, transfer, assign, pledge or otherwise dispose of (whether with or without consideration and whether voluntarily
or involuntarily or by operation of law). 
  
 11. Notices.
Any notice, consent, waiver and other communications required or permitted pursuant to the provisions of this Agreement must be in writing and will be deemed to have been properly given (a) when delivered by hand; (b) when sent by telecopier (with
acknowledgement of complete transmission), provided that a copy is mailed by U.S. certified mail, return receipt requested; (c) three (3) days after sent by certified mail, return receipt requested; or (d) one (1) day after deposit with a nationally
recognized overnight delivery service, in each case to the appropriate addresses and telecopier numbers set forth below: 
  
 If to the Company: 
  
 Avicena Group, Inc. 
 228 Hamilton Avenue

 3rd
Floor 
 Palo Alto, CA 94301 
 Attn:    Belinda Tsao Nivaggioli 
  
 If to the Recipient: 
  
 Leslie Fang

  
  
  
 Each party will be entitled to specify a different address for the receipt of subsequent notices by giving written notice thereof to the other party in
accordance with this Section 11. 

 12. General Provisions. 
  
 (a) Transfers in Violation of Agreement. Any Transfer or attempted Transfer of any Recipient Shares in violation of
any provision of this Agreement shall be null and void, and the Company shall not record such Transfer on its books or treat any purported transferee of such Recipient Shares as the owner of such securities for any purpose. 
  
 (b) Severability. Whenever possible, each provision of this Agreement
will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such
invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such invalid, illegal or unenforceable provision had
never been contained herein. 
  
 (c) Complete Agreement.
This Agreement, those documents expressly referred to herein and other documents of even date herewith embody the complete agreement and understanding among the parties and supersede and preempt any prior understandings, agreements or
representations by or among the parties, written or oral, which may have related to the subject matter hereof in any way. Recipient hereby releases the Company and its affiliates and its and their predecessors from any obligation or liability the
Company or any of its affiliates or its or their predecessors owes or owed to Recipient or any of his or her affiliates and related persons prior to the date hereof. 
  
 (d) Counterparts. This Agreement may be executed in separate counterparts, each of which is deemed to be an original
and all of which taken together constitute one and the same agreement. 
  
 (e) Successors and Assigns. 
  
 (i) All Recipient Shares will continue to be Recipient Shares in the hands of any holder other than Recipient, including any of Recipient’s transferees permitted hereunder (except for the Company and for transferees in a Public Sale).
Except as otherwise provided herein, each such other holder of Recipient Shares will succeed to all rights and obligations attributable to Recipient as a holder of Recipient Shares hereunder. 
  
 (ii) Except as otherwise provided herein, this Agreement
shall bind and inure to the benefit of and be enforceable by Recipient, the Company, and their respective successors and assigns (including subsequent holders of Recipient Shares); provided that the rights and obligations of Recipient under
this Agreement shall not be assignable except in connection with a permitted transfer of Recipient Shares hereunder. 
  
 (f) Choice of Law. The Agreement shall be governed by and interpreted in accordance with the laws of the State of Delaware, without giving effect
to the principle, of the conflicts of laws thereof. 

 (g) Remedies. Each of the parties to this Agreement will be entitled to enforce its rights under
this Agreement specifically, to recover damages and costs (including attorney’s fees) caused by any breach of any provision of this Agreement and to exercise all other rights existing in its favor. The parties hereto agree and acknowledge that
money damages may not be an adequate remedy for any breach of the provisions of this Agreement and that any party may in its sole discretion apply to any court of law or equity of competent jurisdiction (without posting any bond or deposit) for
specific performance and/or other injunctive relief in order to enforce or prevent any violations of the provisions of this Agreement. 
  
 (h) Amendment and Waiver. The provisions of this Agreement may be amended and waived only with the prior written consent of the Company and
Recipient. No cause of conduct or failure or delay in enforcing the provisions of this Agreement shall affect the validity, binding effect or enforceability of this Agreement. 
  
 (i) Adjustment. In the event of any stock split, stock dividend, recapitalization, reorganization, merger,
consolidation, combination, exchange of shares, liquidation, spin-off or other similar change in capitalization or event, or any distribution to holders of Shares other than a regular cash dividend, the number and class of Shares shall be
appropriately adjusted by the Company (such adjustment to be made reasonably and in good faith by the Company). If any adjustment would result in a fractional security being subject to this Agreement, the Company shall pay Recipient in connection
with the vesting, if any, of such fractional security, an amount in cash determined by multiplying (i) such fraction (rounded to the nearest hundredth) by (ii) the Fair Market Value on the vesting date. The decision of the Company regarding any such
adjustment shall be final, binding and conclusive. 
  
 (j)
Business Days. If any time period for giving notice or taking action hereunder expires on a day which is a Saturday, Sunday or holiday in the state in which the Company’s chief executive office is located, the time period shall be
automatically extended to the business day immediately following such Saturday, Sunday or holiday. 
  
 (k) Indemnification and Reimbursement of Payments on Behalf of Recipient. The Company shall be entitled to deduct or withhold from any amounts
owing from the Company to the Recipient any federal, state, local or foreign withholding taxes, excise taxes, or employment taxes (“Taxes”) imposed with respect to the Recipient’s compensation or other payments from the Company
or the Recipient’s ownership interest in the Company, including, but not limited to, wages, bonuses, dividends, the receipt or exercise of stock options and/or the receipt or vesting of restricted stock. The Recipient shall indemnify the
Company for any amounts paid with respect to any such Taxes, together with any interest, penalties and related expenses thereto. 
  
 (l) Termination. This Agreement shall survive the termination of Recipient’s services with the Company and shall remain in full force and
effect after such termination. 

 (m) Generally Accepted Accounting Principles; Adjustments of Numbers. Where any accounting
determination or calculation is required to be made under this Agreement or the exhibits hereto, such determination or calculation (unless otherwise provided) shall be made in accordance with United States generally accepted accounting principles,
consistently applied. 
  
 (n) Waiver of Jury Trial. Each of
the parties hereto hereby irrevocably waives any and all right to trial by jury of any claim or cause of action in any legal proceeding arising out of or related to this Agreement or the transactions or events contemplated hereby or any course of
conduct, course of dealing, statements (whether verbal or written) or actions of any party hereto. The parties hereto each agree that any and all such claims and causes of action shall be tried by a court trial without a jury. Each of the parties
hereto further waives any right to seek to consolidate any such legal proceeding in which a jury trial has been waived with any other legal proceeding in which a jury trial cannot or has not been waived. 
  
 [ REMAINDER OF PAGE LEFT INTENTIONALLY BLANK ] 

 IN WITNESS WHEREOF, the parties hereto have executed this Restricted Stock Purchase Agreement as
of the date first written above. 
  

			
	AVICENA GROUP, INC.
		
	By:	 	 /s/ Nasser Menhall

	 Name:
	 	 Nasser Menhall

	 Its:
	 	 Chairman

	
	 /s/ Leslie Fang

	 Leslie Fang

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