Document:

Amended Executive Employment Agreement, dated July 26, 2005

 Exhibit 10.53 

 
 

 
 AMENDED EXECUTIVE EMPLOYMENT AGREEMENT 

This Executive Employment Agreement (“Agreement”), dated as of July 26, 2005, is made and entered into by
QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (hereinafter the “Company”) and Derek Winstanly (hereinafter the “Executive”). The Company desires to employ Executive as its Executive Vice President,
Strategic Customer Relationships and Business Partnerships and provide adequate assurances to Executive and Executive desires to accept such employment on the terms set forth below. The terms and conditions in the offer letter dated July 26,
2005 are incorporated herein by reference. 
 In consideration of the mutual promises set forth below and other good and
valuable new consideration, the receipt and sufficiency of which the parties acknowledge, the Company and Executive agree as follows: 
 1. EMPLOYMENT. The Company employs Executive and Executive accepts employment on the terms and conditions set forth in this Agreement 

2. NATURE OF EMPLOYMENT. Executive shall serve as Executive Vice President, Strategic Customer Relationships and Business
Partnerships, and have such responsibilities and authority as the Company may assign from time to time. Additionally, Executive agrees to perform such other duties consonant with those of an executive at his level as the Company may set from time to
time. 
 2.1 Executive shall perform all duties and exercise all authority in accordance with, and shall otherwise comply
with, all Company policies, procedures, practices and directions. 
 2.2 Executive shall devote all working time, best
efforts, knowledge and experience to perform successfully his duties and advance the Company’s and/or its Affiliates’ interests. During his employment, Executive shall not engage in any other business activities of any nature whatsoever
(including board memberships) for which he receives compensation without the Company’s prior written consent; provided, however, this provision does not prohibit him from personally owning and trading in stocks, bonds, securities, real estate,
commodities or other investment properties for his own benefit, which do not create actual or potential conflicts of interest with the Company and/or its Affiliates. As used in this Agreement, “Affiliates” shall mean: (i) any
Company’s parent, subsidiary or related entity; and/or (ii) any entity directly or indirectly controlled or beneficially owned in whole or part by the Company or Company’s parent, subsidiary or related entity. 

2.3 Executive’s base of operation shall be Research Triangle Park, North Carolina subject to business travel as may be
necessary in the performance of Executive’s duties. 

  
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 3. COMPENSATION. 

3.1 Base Salary. Executive’s monthly salary for all services rendered shall be $33,333.33 (less applicable
withholdings), payable in accordance with the Company’s policies, procedures and practices as they may exist from time to time. Executive’s salary shall be reviewed in accordance with the Company’s policies, procedures and practices
as they may exist from time to time. 
 3.2 Executive Compensation Plan. Executive shall continue to participate
as a Level 2 employee in the Executive Compensation Plan (or successor plans) (“ECP”) which may be made available from time to time to Company executives at Executive’s level; provided, however, that Executive’s
participation is subject to the applicable terms, conditions and eligibility requirements of the plan documents, some of which are within the plan administrator’s discretion, as they may exist from time to time. 

3.3 Tax Returns. Executive shall be entitled to tax return preparation and reasonable financial planning, consultation and
advice by the Company’s accounting firm and/or legal counsel and/or financial consultants as the Company may provide from time to time to Company executives at Executive’s level. 

3.4 Other Benefits. Executive may participate in available medical, dental and disability insurance, 401 (k), pension,
personal leave, car allowance and other employee benefit plans and programs, except Executive may not receive severance payments other than as specified in this Agreement; provided, however, that Executive’s participation in benefit plans and
programs is subject to the applicable terms, conditions and eligibility requirements of these plans and programs, some of which are within the plan administrator’s discretion, as they may exist from time to time. 

3.5 Business Expenses. Executive shall be reimbursed for reasonable and necessary expenses actually incurred by him in
performing services under this Agreement in accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures and practices as they may exist from time to time. Expenses covered by this provision
include but are not limited to travel, entertainment, professional dues, subscriptions and dues, fees and expenses associated with membership in various professional, and business and civic associations of which Executive’s participation is in
the Company’s best interest. 
 3.6 Nothing in this Agreement shall require the Company to create, continue or
refrain from amending, modifying, revising or revoking any of the plans, programs or benefits set forth in Sections 3.2 through 3.5. Any amendments, modifications, revisions and revocations of these plans, programs and benefits shall apply to
Executive. 

  
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 3.7 If, at any time during which Executive is receiving salary or post-termination
payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its discretion, may reduce his salary or post-termination payments by the amount of such disability
payments. 
 4. TERM OF EMPLOYMENT. The original term of employment under this Agreement shall be for a one
(1) year period commencing on June 1, 2005, and terminating on May 31, 2006, subject to the following provisions: 
 4.1 Upon the expiration of the original or any renewal term of employment, Executive’s employment shall be automatically renewed for an additional one (1) year period unless, at least
ninety (90) days prior to the renewal date, either party gives the other party written notice of its intent not to continue the employment relationship. During any renewal term of employment, the terms, conditions and provisions set forth in
this Agreement shall remain in effect unless modified in accordance with Section 15. 
 4.2 Either party may
terminate the employment relationship without cause at any time upon giving the other party ninety (90) days written notice. 
 4.3 The Company may terminate the Executive’s employment relationship immediately without notice at any time for the following reasons which shall constitute “Cause”:
(i) Executive’s death; (ii) Executive’s physical or mental inability to perform the essential functions of his duties satisfactorily for a period of 180 consecutive days or 180 days in total within a 365-day period as determined
by the Company in its reasonable discretion and in accordance with applicable law; (iii) any act or omission of Executive constituting or rising to the level of willful misconduct (including willful violation of the Company’s policies),
gross negligence, fraud, misappropriation, embezzlement, criminal behavior, conflict of interest or competitive business activities which, as determined by the Company in its reasonable discretion, may cause material harm, or any other actions that
are materially detrimental to the Company or any Affiliates’ interest; (iv) any other reason recognized as “cause” under applicable law; or (v) Executive’s material breach of this Agreement. 

4.4 Executive may terminate Executive’s employment with the Company as a result of the Company’s failure to cure its
material breach of this Agreement after Executive has given the Company written notice of the material breach and at least thirty (30) days to cure the breach (or such longer period as may be reasonably required to cure the breach as long as
the Company is making good faith efforts to do so). The parties agree that a change in Executive’s title, reporting relationship, duties or responsibilities does not amount to a material breach of this Agreement. 

4.5 This Agreement shall terminate upon the termination of the employment relationship with the following exceptions:
Section 6 (Trade Secrets, Confidential Information, Company Property and Competitive Business Activities), 7 (Intellectual Property Ownership), 8 (License), 9 

  
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(Release) shall survive the termination of Executive’s employment and/or the expiration or termination of this Agreement, regardless of the reasons for such expiration or termination.

 5. COMPENSATION AND BENEFITS UPON TERMINATION. 

5.1 The Company’s obligation to compensate Executive ceases on the effective termination date except as to: (i) amounts
due at that time; (ii) any amount subsequently due pursuant to the plan described in Section 3.2; and (iii) any compensation and/or benefits to which he may be entitled to receive pursuant to Sections 5.2, 5.3, or 5.4 

5.2 If the Company terminates Executive’s employment pursuant to Sections 4.1 (notice of non-renewal) or 4.2 (without cause),
then the Company’s sole obligation shall be to pay Executive: (i) amounts due on the effective termination date; (ii) any amounts subsequently due pursuant to the plan described in Section 3.2; and (iii) subject to
Executive’s compliance with Sections 6,7,8 and 9 and subject to Sections 3.7 and 5.6, an amount equal to 1.55 times his then current monthly salary (less applicable withholdings), for (36) thirty-six months, payable in equal monthly
installments. 
 5.3 If the Company terminates Executive’s employment as provided in Sections 4.3 (i) (death),
(ii) (physical or mental inability to perform), (iii) (materially harmful acts or omissions), (iv) (other reasons recognized as “cause”) or (v) (Executive’s material breach) or if the Executive terminates his
employment pursuant to Section 4.1 (notice of non-renewal) or Section 4.2 (without cause), then the Company’s sole obligation shall be to pay Executive: (i) amounts due on the effective termination date and (ii) any amounts
subsequently due pursuant to the plan described in Section 3.2. Executive, except when employment terminates pursuant to Section 4.3(i) (death), shall comply with Sections 6, 7, 8 and 9 of this Agreement upon expiration or termination of
this Agreement. 
 5.4 If Executive terminates the employment relationship pursuant to Section 4.4 of this
Agreement, then the Company’s sole obligation to Executive in lieu of any other damages or other relief to which he otherwise may be entitled shall be (i) an amount equal to amounts due at the time of his termination; and (ii) subject
to Executive’s compliance with Sections 6, 7, 8 and 9 and subject to Sections 3.7 and 5.6, liquidated damages in an amount equal to his then current monthly salary (less applicable withholdings) for the twelve (12) month non-competition
period set forth in Section 6.3, payable in equal monthly installments. 
 5.5 The Company’s obligation to
provide the payments under Sections 5.2 and 5.4 is conditioned upon Executive’s execution of an enforceable release of all claims and his compliance with Sections 6, 7, 8 and 9 of this Agreement. If Executive chooses not to execute such a
release or fails to comply with these sections, then the Company’s obligation to compensate him ceases on the effective termination date except as to amounts due at that time and any amount subsequently due pursuant to the plan described in
Section 3.2. 

  
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 5.6 Executive is not entitled to receive any compensation or benefits upon his
termination except as: (i) set forth in this Agreement; (ii) otherwise required by law; or (iii) otherwise required by any employee benefit plan in which he participates. Nothing in this Agreement, however, is intended to waive or
supplant any death, disability, retirement, 401(k) or pension benefits to which he may be entitled under employee benefit plans in which he participates. 
 6. TRADE SECRETS, CONFIDENTIAL INFORMATION, COMPANY PROPERTY AND COMPETITIVE BUSINESS ACTIVITIES. Executive acknowledges that: (i) the Company and its Affiliates have worldwide business
operations, a worldwide customer base, and are engaged in the business of contract research, sales and marketing, healthcare policy consulting and health information management services to the worldwide pharmaceutical, biotechnology, medical device
and healthcare industries; (ii) by virtue of his employment by and upper-level position with the Company, he has or will have access to Trade Secrets and Confidential Information (as defined in Sections 6.1(5) and 6.1(6)) of the Company and its
Affiliates, including valuable information about their worldwide business operations and entities with whom they do business in various locations throughout the world, and has developed or will develop relationships with their customers and others
with whom they do business in various locations throughout the world; and (iii) the Trade Secret, Confidential Information and Competitive Business Activities’ provisions set forth in this Agreement are reasonably necessary to protect the
Company’s and its Affiliates’ legitimate business interests, are reasonable as to the time, territory and scope of activities which are restricted, do not interfere with public policy or public interest and are described with sufficient
accuracy and definiteness to enable him to understand the scope of the restrictions imposed on him/her. 
 6.1 Trade
Secrets and Confidential Information. Executive acknowledges that: (i) the Company and/or its Affiliates will disclose to him certain Trade Secrets and Confidential Information; (ii) Trade Secrets and Confidential Information are
the sole and exclusive property of the Company and/or its Affiliates (or a third party providing such information to the Company and/or its Affiliates) and the Company and/or its Affiliates or such third party owns all worldwide rights therein under
patent, copyright, trademarks, trade secret, confidential information or other property right; and (iii) the disclosure of Trade Secrets and Confidential Information to Executive does not confer upon him any license, interest or rights of any
kind in or to the Trade Secrets or Confidential Information. 
 6.1(1) Executive may use the Trade Secrets and
Confidential Information only while he is employed or otherwise retained by the Company and only then in accordance with applicable Company policies and procedures and solely for the Company’s benefit. Except as authorized in the performance of
services for the Company, Executive will hold in confidence and will not, either directly or indirectly, in any form, by any means, or for any purpose, disclose, reproduce, distribute, transmit, reverse engineer, decompile, disassemble, or transfer
Trade Secrets or Confidential Information or any portion thereof. Upon the Company’s request, or at the end of the employment relationship, Executive shall return Trade Secrets and Confidential Information and all related materials. 

  
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 6.1(2) If Executive is required to disclose Trade Secrets or Confidential
Information pursuant to a court order, subpoena or other government process or such disclosure is necessary to comply with applicable law or defend against claims, he shall: (i) notify the Company promptly before any such disclosure is made;
(ii) at the Company’s request and expense take all reasonably necessary steps to defend against such disclosure, including defending against the enforcement of the court order, other government process or claims; and (iii) permit the
Company to participate with counsel of its choice in any proceeding relating to any such court order, subpoena, other government process or claims. 
 6.1(3) Executive’s obligations with regard to Trade Secrets shall remain in effect for as long as such information shall remain a trade secret under applicable law. 

6.1(4) Executive’s obligations with regard to Confidential Information shall remain in effect while he is employed or
otherwise retained by the Company and/or its Affiliates and for fifteen (15) years thereafter. 
 6.1(5) As used in
this Agreement, “Trade Secrets” means information of the Company, its Affiliates and its and/or their licensors, suppliers, customers, or prospective licensors or customers, including, but not limited to, data, formulas, patterns,
compilations, programs, devices, methods, techniques, processes, financial data, financial plans, product plans, or lists of actual or potential customers or suppliers, which: (i) derives independent actual or potential commercial value, from
not being generally known to or readily ascertainable through independent development or reverse engineering by persons or entities who can obtain economic value from its disclosure or use; and (ii) is the subject of efforts that are reasonable
under the circumstances to maintain its secrecy. 
 6.1(6) As used in this Agreement, “Confidential
Information” means information other than Trade Secrets, that is of value to its owner and is treated as confidential, including, but not limited to, future business plans, licensing strategies, advertising campaigns, information regarding
executives and employees, and the terms and conditions of this Agreement; provided, however, Confidential Information shall not include information which is in the public domain or becomes public knowledge through no fault of Executive. 

6.2 Company Property. Upon termination of his employment, Executive shall: (i) deliver to the Company all records,
memoranda, data, documents and other property of any description which refer or relate in any way to Trade Secrets or Confidential Information, including all copies thereof, which are in his possession, custody or control; (ii) deliver to the
Company all Company and/or Affiliates property (including, but not limited to, keys, credit cards, client files, contracts, proposals, work in process, manuals, forms, computer stored work in process and other computer data, research materials,
other items of business information concerning any Company and/or Affiliates client, or Company and/or Affiliates business or business methods, including all copies thereof) which is in his 

  
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possession, custody or control; (iii) bring all such records, files and other materials up to date before returning them; and (iv) fully cooperate with the Company in winding up his
work and transferring that work to other individuals designated by the Company. 
 6.3 Competitive Business
Activities. During his employment and the one (1) year following his effective termination date (regardless of the reason for the termination and regardless of whether initiated by Executive or Company), Executive will not engage in the
following activities: 
 (A) on Executive’s own or another’s behalf, whether as an officer, director,
stockholder, partner, associate, owner, employee, consultant or otherwise, directly or indirectly: 
 (i) compete with the
Company or its Affiliates within the geographical areas set forth in Section 6.3(B)(1); except that Executive, without violating this provision, may become employed by any company which is engaged in the integrated development, discovery,
manufacture, marketing and sale of pharmaceutical drugs that does not engage in contract sales and/or research; 
 (ii) within
the geographical areas set forth in Section 6.3(1), solicit or do business which is the same, similar to or otherwise in competition with the business engaged in by the Company or its Affiliates, from or with persons or entities: (A) who
are customers of the Company or its Affiliates; (B) who Executive or someone for whom he was responsible solicited, negotiated, contracted or serviced on the Company’s or its Affiliates’ behalf; or (C) who were customers of the
Company or its Affiliates at any time during the last year of Executive’s employment with the Company; 
 (iii) offer
employment to or otherwise solicit for employment any employee or other person who had been employed by the Company or its Affiliates during the last year of Executive’s employment with the Company; or 

(B) directly or indirectly take any action which is materially detrimental or otherwise intended to be adverse to the
Company’s and/or Affiliates’ goodwill, name, business relations, prospects and operations. 
 6.3(1) The
restrictions set forth in Section 6.3 apply to the following geographical areas; (i) within a 60-mile radius of the Company and/or its Affiliates where the Executive had an office during the Executive’s employment with the Company
and/or its Affiliates; (ii) any city, metropolitan area, county (or similar political subdivision in foreign countries) in which Executive’s substantial services were provided, or for which Executive had substantial responsibility, or in
which Executive performed substantial work on Company and/or Affiliates’ projects, while employed by the Company; and (iii) any city, metropolitan area, county (or similar political subdivisions in foreign

  
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countries) in which the Company or its Affiliates is located or does or, during Executive’s employment with Company, did business. 

6.3(2) Notwithstanding the foregoing, Executive’s ownership, directly or indirectly, of not more than one percent of the
issued and outstanding stock of a corporation the shares of which are regularly traded on a national securities exchange or in the over-the-counter market shall not violate Section 6.3. 

6.4 Remedies. Executive acknowledges that his failure to abide by the Trade Secrets, Confidential Information, Company
Property or Competitive Business Activities provisions of this Agreement would cause irreparable harm to the Company and/or its Affiliates for which legal remedies would be inadequate. Therefore, in addition to any legal or other relief to which the
Company and/or its Affiliates may be entitled by virtue of Executive’s failure to abide by these provisions: (i) the Company will be released of its obligations under this Agreement to make any post-termination payments, including but not
limited to those otherwise available pursuant to Sections 5.2, 5.3, or 5.4, (ii) the Company may seek legal and equitable relief, including but not limited to preliminary and permanent injunctive relief, for Executive’s actual or
threatened failure to abide by these provisions; (iii) Executive will return all post-termination payments received pursuant to this Agreement, including but not limited to those received pursuant to Sections 5.2, 5.3, 5.4, 5.5;
(iv) Executive will indemnify the Company and/or its Affiliates for all expenses including attorneys’ fees in seeking to enforce these provisions; and (v) if, as a result of Executive’s failure to abide by the Trade Secrets,
Confidential Information, Company Property or Competitive Business Activities provisions, any commission or fee becomes payable to Executive or to any person, corporation or other entity with which Executive has become employed or otherwise
associated, Executive shall pay the Company or cause the person, corporation or other entity with whom he has become employed or otherwise associated to pay the Company an amount equal to such commission or fee. In the event that the Company
exercises its right to discontinue payments under this provision and/or Executive returns all post-termination payments received pursuant to this Agreement, Executive shall remain obligated to abide by the Trade Secrets, Confidential Information,
Company Property and Competitive Business Activities provisions set forth in this Agreement. 
 6.5 Tolling. The
period during which Executive must refrain from the activities set forth in Sections 6.1 and 6.3 shall be tolled during any period in which he fails to abide by these provisions. 

6.6 Other Agreements. Nothing in this Agreement shall terminate, revoke or diminish Executive’s obligations or the
Company’s and/or its Affiliates’ rights and remedies under law or any agreements relating to trade secrets, confidential information, non-competition or intellectual property which Executive has executed in the past or may execute in the
future or contemporaneously with this Agreement. 

  
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 7. INTELLECTUAL PROPERTY OWNERSHIP. 

7.1 As used in this Agreement, “Work Product” shall mean the data, materials, documentation, computer programs,
inventions (whether or not patentable), improvements, modifications, discoveries, methods, developments, picture, audio, video, artistic works and all works of authorship, including all worldwide rights therein under patent, copyright, trademark,
trade secret, confidential information or other property right, created or developed in whole or in part by Executive, while employed by the Company (whether developed during work hours or not), whether prior or subsequent to the date of this
Agreement. 
 7.2 All Work Product shall be considered work made for hire by Executive and owned by the Company. If any
of the Work Product may not, by operation of law be considered work made for hire by Executive for the Company, or if ownership of all right, title, and interest of the intellectual properly rights therein shall not otherwise vest exclusively in the
Company, Executive hereby assigns to the Company, and upon the future creation thereof automatically assigns to the Company, without further consideration, the ownership of all Work Product. The Company shall have the right to obtain and hold in its
own name copyrights, registrations and any other protection available in the Work Product. Executive agrees to perform, during or after his employment, such further acts which the Company requests as may be necessary or desirable to transfer,
perfect and defend its ownership of the Work Product. 
 7.3 Notwithstanding the foregoing, this Agreement shall not
require assignment of any invention that: (i) Executive developed entirely on his own time without using the Company’s equipment, supplies, facilities, Trade Secrets or Confidential Information; and (ii) does not relate to the
Company’s business or actual or anticipated research or development or result from any work performed by Executive for the Company. 
 7.4 Executive shall promptly disclose to the Company in writing all Work Product conceived, developed or made by him/her, individually or jointly. 

8. LICENSE. To the extent that any preexisting materials are contained in Work Product which Executive delivers to the
Company or its customers, Executive grants to the Company an irrevocable, nonexclusive, worldwide, royalty-free license to: (i) use and distribute (internally or externally) copies of, and prepare derivative works based upon, such preexisting
materials and derivative works thereof; and (ii) authorize others to do any of the foregoing. 
 9. RELEASE.
Executive acknowledges that: (i) as a part of his services, he may provide his image, likeness, voice or other characteristics; and (ii) the Company may use his image, likeness, voice or other characteristics and expressly releases the
Company, its Affiliates and its and/or their agents, employees, licensees and assigns from and against any and all claims which he has or may have for invasion of privacy, right of privacy, defamation, copyright infringement or any other causes of
action 

  
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arising out of the use, adaptation, reproduction, distribution, broadcast or exhibition of such characteristics. 
 10. EMPLOYEE REPRESENTATION. Executive represents and warrants that his employment and obligations under this Agreement will not (i) breach any duty or obligation he owes to another or
(ii) violate any law, recognized ethics standard or recognized business custom. 
 11. OFFICERS AND DIRECTORS
INDEMNIFICATION PROVISIONS. To the extent Executive serves as a Company and/or Affiliate officer or director, Executive shall be entitled to insurance under Company’s directors and officers’ indemnification policies comparable to
any such insurance covering executives of the applicable entity serving in similar capacities. Further, the Company’s bylaws shall contain provisions granting to Executive the maximum indemnity protection allowed under applicable law and the
Company hereby agrees to indemnify and hold harmless Executive in accordance with such maximum indemnity protection allowed under applicable law. 
 12. NOTICES. All notices, requests, demands and other communications required or permitted to be given in writing pursuant to this Agreement shall be deemed given and received: (A) upon
delivery if delivered personally; (B) on the fifth (5th) day after being deposited with the U.S. Postal Service if mailed by first class mail, postage prepaid, registered or certified with return receipt requested, at the addresses set
forth below; (C) on the next day after being deposited with a reliable overnight delivery service; or (D) upon receipt of an answer back confirmation, if transmitted by telefax, addressed to the below indicated telefax number. Notice given
in another manner shall be effective only if and when received by the addressee. For purposes of notice, the addresses and telefax number (if any) of the parties shall be as follows: 

 

					
	If to the Executive, to:	  	Derek Winstanly	  	
		  	104 Boundary Street	  	
		  	Chapel Hill, North Carolina 27514	  	
			
	If to the Company, to:	  	Quintiles Transnational Corp.	  	
		  	4709 Creekstone Drive	  	
		  	Riverbirch Building, Suite 300	  	
		  	Durham, North Carolina 27703	  	
		  	Attn: General Counsel	  	

 provided that: (A) each party shall have the right to change its address for notice, and the person who is to
receive notice, by the giving of fifteen (15) days’ prior written notice to the other party in the manner set forth above; and (B) notices shall be effective if given to the other party in the manner set forth above regardless of
whether a copy was received by the additional addressee specified above. 

  
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 13. WAIVER OF BREACH. The Company’s or Executive’s waiver of any
breach of a provision of this Agreement shall not waive any subsequent breach by the other party. 
 14. ENTIRE
AGREEMENT. Except as expressly provided in this Agreement, this Agreement: (i) supersedes all other understandings and agreements, oral or written, between the parties with respect to the subject matter of this Agreement; and
(ii) constitutes the sole agreement between the parties with respect to this subject matter. Each party acknowledges that: (i) no representations, inducements, promises or agreements, oral or written, have been made by any party or by
anyone acting on behalf of any party, which are not embodied in this Agreement; and (ii) no agreement, statement or promise not contained in this Agreement shall be valid. No change or modification of this Agreement shall be valid or binding
upon the parties unless such change or modification is in writing and is signed by the parties. 
 15.
SEVERABILITY. If a court of competent jurisdiction holds that any provision or sub-part thereof contained in this Agreement is invalid, illegal or unenforceable, that invalidity, illegality or unenforceability shall not affect any other
provision in this Agreement. Additionally, if any of the provisions, clauses or phrases in the Trade Secrets, Confidential Information or Competitive Business Activities provisions set forth in this Agreement are held unenforceable by a court of
competent jurisdiction, then the parties desire that they be “blue-penciled” or rewritten by the court to the extent necessary to render them enforceable. 
 16. PARTIES BOUND. The terms, provisions, covenants and agreements contained in this Agreement shall apply to, be binding upon and inure to the benefit of the Company’s successors and
assigns. The Company, at its discretion, may assign this Agreement to an affiliate or a successor. Because this Agreement is personal to Executive, Executive may not assign this Agreement. 

17. GOVERNING LAW. This Agreement and the employment relationship created by it shall be governed by North Carolina law
without giving effect to North Carolina choice of law provisions. The parties hereby consent to jurisdiction in North Carolina for the purpose of any litigation relating to this Agreement 

  
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 IN WITNESS WHEREOF, the parties have entered into this Agreement on the day and year first written above.

  

									
		 		 		 	 /s/ Derek Winstanly

		 		 		 	 Executive

				
		 		 		 	 QUINTILES TRANSNATIONAL CORP.

					
		 		 		 	By:	 	/s/ Michael Mortimer
		 		 		 		 	 Michael Mortimer

		 		 		 		 	Title: EVP, Global Human Resources

  
 12First Amendment, dated December 30, 2008

 Exhibit 10.54 
 FIRST AMENDMENT TO 
 AMENDED EXECUTIVE EMPLOYMENT AGREEMENT

 This FIRST AMENDMENT TO AMENDED EXECUTIVE EMPLOYMENT AGREEMENT (“First Amendment”) is made and entered
into as of the 30 day of December, 2008 by and between QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the “Company”), and DEREK WINSTANLY (“Executive”). 

WHEREAS, Executive is currently employed under an Amended Executive Employment Agreement with the Company, dated July 26,
2005 (the “Amended Employment Agreement”), and currently serves as Executive Vice President, Strategic Business Partnerships, directly reporting to the Chairman and Chief Executive Officer of the Company; 

WHEREAS, the Company and Executive desire to amend the Amended Employment Agreement to memorialize new compensation arrangements
approved by the Company’s Board of Directors in December 2007, and to evidence compliance with Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively,
“Section 409A”); and 
 NOW, THEREFORE, in consideration of the mutual covenants and agreements set forth
below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and Executive agree that the Amended Employment Agreement shall be amended as follows: 

1. COMPENSATION. Section 3, COMPENSATION, of the Amended Employment Agreement is deleted in its entirety and the following
Section is inserted in lieu thereof: 
 3. COMPENSATION. 

3.1 Base Salary. Executive’s annual salary for all services rendered shall be Four Hundred Fifty
Thousand and No/100 Dollars ($450,000.00) (less any applicable taxes and withholdings), payable in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. Executive’s salary may be reviewed
and is subject to adjustment in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. 
 3.2 Performance Incentive Plan. Executive may participate on a basis commensurate with his position as a senior executive officer, as determined by the Company, in the Quintiles Performance
Incentive Plan. For the year 2008, Executive is eligible to participate at a target level of eighty-five percent (85%) of his annual base salary. This target level may be increased or decreased in subsequent years at the discretion of the
Company. Beginning with the year 2008, the 

 
Performance Incentive Plan cap shall increase to two hundred percent (200%) of target, based on Company and personal performance. Any Bonus paid to Executive shall be less applicable
withholdings and shall be distributed pursuant to policies as determined by the Company, but in no event later than March 15 of the calendar year following the calendar year in which such Bonus was earned. 

3.3 Annual Executive Allowance. Each year during the term of this Amended Employment Agreement,
Executive shall be entitled to receive payment of Thirty Thousand and No/100 Dollars ($30,000.00), less any applicable taxes and withholdings, as an Executive Allowance. The Executive Allowance shall be paid in substantially equal installment
payments in accordance with the Company’s normal payroll practices. This Executive Allowance is intended to be used for miscellaneous expenses and allowances previously provided by the Company such as car allowance, tax return preparation fees,
financial planning fees, legal fees, and the micropurchase plan. 
 3.4 Other Benefits. Executive
may participate in all medical, dental and disability insurance, 401 (k), pension, personal leave, and other benefit plans and programs provided by the Company to other employees at Executive’s level except that Executive may not receive
severance payments other than as specified in this Amended Employment Agreement; provided, however, that Executive’s participation in such benefit plans and programs is subject to the applicable terms, conditions and eligibility requirements of
these plans and programs, some of which are in the plan administrator’s discretion, as they may exist from time to time. 
 3.5 Business Expenses. Executive shall be reimbursed for reasonable and necessary expenses actually incurred by him in performing services under this Amended Employment Agreement in
accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures, and practices as they may exist from time to time. Expenses covered by this provision include, but are not limited to, travel,
entertainment, professional dues and subscriptions, and dues, fees, and expenses associated with membership in various professional and business and civic associations in which Executive’s participation is in the Company’s best interest.
All such reimbursements shall be made no later than March 15 of the calendar year following the calendar year in which the expenses were incurred. 
 3.6 Modifications or Revisions of Benefit Plans and Programs. Nothing in this Amended Employment Agreement shall require the Company to create, continue, or refrain from amending,
modifying, revising, or revoking any of the plans, programs, or benefits 

  
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set forth in Sections 3.2 through 3.5. Any amendments, modifications, revisions, and revocations of these plans, programs, and benefits shall apply to Executive. 

3.7 Offset for Disability Payments. If, at any time, during which Executive is receiving salary or
post-termination payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its discretion, may reduce his salary or post-termination payments by the amount of
such disability payments.” 
 2. TERM OF EMPLOYMENT. Section 4, TERM OF EMPLOYMENT, of the Amended Employment
Agreement shall be amended as follows: 
 Executive’s Right to Terminate for a Breach by the
Company. Section 4.4 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 
 “4.4 Executive may terminate employment in the event the Company materially breaches this Amended Employment Agreement if: (i) Executive provides the Company with written notice of the
material breach of this Amended Employment Agreement within ninety (90) days of the initial actions or inactions of the Company giving rise to such breach; (ii) the Company has not cured such breach within ninety (90) days of such
notice (“Cure Period”); and (iii) if the Company fails to cure such breach, Executive terminates employment under this Amended Employment Agreement within ninety (90) days of the expiration of the Cure Period. The parties agree
that a change in Executive’s title, reporting relationship, duties or responsibilities does not amount to a material breach of this Amended Employment Agreement.” 
 3. COMPENSATION AND BENEFITS UPON TERMINATION. Section 5, COMPENSATION AND BENEFITS UPON TERMINATION, of the Amended Employment Agreement shall be amended as follows: 

 

	 	(a)	Termination by the Company Without Cause or for Non-Renewal. Section 5.2 (iii) of the Amended Employment Agreement is deleted in its
entirety and the following Section is inserted in lieu thereof: 

 “(iii) subject to
Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, an amount equal to the sum of 1.55 times his then current monthly base salary (less applicable withholdings), multiplied by thirty six (36), plus an amount
equal to three (3) times his Annual Executive Allowance under Section 3.3, payable in lump sum (less applicable withholdings) within ten (10) calendar days following the effective date of the general release

  
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required by Section 5.5, but not later than ninety (90) days following termination.” 
  

	 	(b)	Termination by Executive for a Material Breach. Section 5.4 (ii) of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 

 “(ii) subject to Executive’s
compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, an amount equal to the sum of 1.55 times his then current monthly base salary (less applicable withholdings), multiplied by thirty six (36), plus an amount equal to three
(3) times his Annual Executive Allowance under Section 3.3, payable in lump sum (less applicable withholdings) within ten (10) calendar days following the effective date of the general release required by Section 5.5, but not
later than ninety (90) days following termination.” 
  

	 	(c)	Release of Claims as a Condition of Payment from the Company. Section 5.5 of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 

 “5.5 Notwithstanding any provision
of this Amended Employment Agreement to the contrary, the Company’s obligation to provide the payments and benefits under Sections 5.2, 5.4 and 5.7 of this Amended Employment Agreement is conditioned upon Executive’s execution of an
enforceable release of claims and his compliance with Sections 6, 7, 8 and 9 of this Amended Employment Agreement. If Executive chooses not to execute such a release or fails to comply with these sections, then the Company’s obligation to
compensate him ceases on the effective termination date except as to amounts due at the time and any amount subsequently due pursuant to the plan described in Section 3.2. The release of claims shall be provided to Executive within thirty
(30) days of his separation from service and Executive must execute it within the time period specified in the release (which shall not be longer than forty five (45) days from the date of receipt). Such release shall not be effective
until any applicable revocation period has expired.” 
  

	 	(d)	Benefit Continuation. A new Section 5.7 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu
thereof: 

 “5.7 In the event Executive is receiving payments under Sections 5.2 or
5.4, and subject to Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.5, Executive shall be entitled to a lump sum payment equal to thirty six (36) multiplied by the Company’s monthly cost for
providing the type of medical, dental, vision, long term disability and term life insurance coverage, as applicable, in effect for Executive (e.g., family coverage vs. employee-only coverage) at the time of his termination, payable in a one-time

  
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lump sum payment, less any applicable tax withholdings, within ten (10) calendar days following the effective date of the general release required by Section 5.5, but not later than
ninety (90) days following termination from employment. Any payment under this section that is includible in Executive’s gross income shall be increased by an additional amount equal to the Federal income tax applicable to such payment
determined by applying the highest marginal Federal tax rate in effect at the payment date. Executive shall bear full responsibility for applying for COBRA continuation coverage and for obtaining coverage under any other insurance policy following
termination of employment, and nothing herein shall constitute a guarantee of COBRA continuation coverage or benefits or a guarantee of eligibility for health, dental, long term disability or term life insurance coverage.” 

4. SECTION 409A OF THE INTERNAL REVENUE CODE. The following provisions shall be added to the end of the Amended Employment
Agreement as Section 18: 
 “18 Section 409A of the Internal Revenue Code.

 18.1 Parties’ Intent. The parties intend that the provisions of this Amended Employment Agreement comply
with the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”) and all provisions of this Amended Employment Agreement shall be construed in a manner consistent with
the requirements for avoiding taxes or penalties under Section 409A. If any provision of this Amended Employment Agreement (or of any award of compensation, including equity compensation or benefits) would cause Executive to incur any
additional tax or interest under Section 409A, the Company shall, upon the specific request of Executive, use its reasonable business efforts to in good faith reform such provision to comply with Code Section 409A; provided, that to
the maximum extent practicable, the original intent and economic benefit to Executive and the Company of the applicable provision shall be maintained, and the Company shall have no obligation to make any changes that could create any additional
economic cost or loss of benefit to the Company. The Company shall timely use its reasonable business efforts to amend any plan or program in which Executive participates to bring it in compliance with Section 409A. Notwithstanding the
foregoing, the Company shall have no liability with regard to any failure to comply with Section 409A so long as it has acted in good faith with regard to compliance therewith. 

18.2 Separation from Service. A termination of employment shall not be deemed to have occurred for purposes of any provision
of this Amended Employment Agreement providing for the payment of any amounts or benefits upon or following a termination of employment unless such termination also constitutes a “Separation from Service” within the meaning of
Section 409A and, for purposes of any such provision of this Amended Employment Agreement, references to a “termination,” “termination of employment,” “separation from service” or like terms shall mean Separation
from Service. 

  
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 18.3 Separate Payments. Each installment payment required under this Amended
Employment Agreement shall be considered a separate payment for purposes of Section 409A. 
 18.4 Delayed Distribution
to Key Employees. If the Company determines in accordance with Sections 409A and 416(i) of the Code and the regulations promulgated thereunder, in the Company’s sole discretion, that Executive is a Key Employee of the Company on the
date his/her employment with the Company terminates and that a delay in benefits provided under this Amended Employment Agreement is necessary to comply with Code Section 409A(A)(2)(B)(i), then any severance payments and any continuation of
benefits or reimbursement of benefit costs provided by this Amended Employment Agreement, and not otherwise exempt from Section 409A, shall be delayed for a period of six (6) months following the date of termination of Executive’s
employment (the “409A Delay Period”). In such event, any severance payments and the cost of any continuation of benefits provided under this Amended Employment Agreement that would otherwise be due and payable to Executive during the 409A
Delay Period shall be paid to Executive in a lump sum cash amount in the month following the end of the 409A Delay Period. For purposes of this Amended Employment Agreement, “Key Employee” shall mean an employee who, on an Identification
Date (“Identification Date” shall mean each December 31) is a key employee as defined in Section 416(i) of the Code without regard to paragraph (5) thereof. If Executive is identified as a Key Employee on an Identification
Date, then Executive shall be considered a Key Employee for purposes of this Amended Employment Agreement during the period beginning on the first April 1 following the Identification Date and ending on the following March 31.”

 5. COUNTERPARTS. This First Amendment may be executed in counterparts, each of which shall be an original, with the
same effect as if the signatures affixed thereto were upon the same instrument. 
 6. DEFINITIONS. All terms used in this
First Amendment shall have the same definitions as used in the Amended Employment Agreement, unless otherwise provided herein. All references to “Amended Employment Agreement” shall include all modifications made by this First Amendment,
unless provided otherwise. 
 7. EFFECT OF AMENDMENT. Except as amended hereby, the Amended Employment Agreement shall
remain in full force and effect and is hereby ratified and confirmed by the Company and Executive in all respects. 
 [Remainder
of page intentionally left blank] 

  
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 IN WITNESS WHEREOF, this First Amendment has been duly executed as of the day and year set
forth above. 
  

					
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ Michael Mortimer

		 	Name:	 	Michael Mortimer
		 	Title:	 	 Executive Vice President and

Chief Administrative Officer

	
	EXECUTIVE:
	
	 /s/ Derek Winstanly

	Derek Winstanly

  
 7

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