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EXHIBIT 10.21    
    

ADDENDUM TO LEASE BETWEEN EUS PARTNERS, THE

SUCCESSOR TO MICHAEL L. HIGHTOWER, LESSOR, AND

NUVASIVE, INC. AS LESSEE; LEASE DATED NOVEMBER 1999;

ADDENDUM DATED MARCH 25, 2002

Both
parties to this lease agree to the following modifications: 

54.    On
August 17, 2001 Michael L. Hightower, the first Lessor under this Lease, sold the Building to EUS Partners. EUS has assumed all responsibilities of Lessor under this Lease 

53.    Both
parties acknowledge that Lessee occupies the entire Building and that Lessee's share of Common Area Expenses per Paragraph 1.6(b) is 100%. 

Lessee
hereby agrees to perform and pay for the items relating to the operation of the Building, that are described in Paragraph 4.2(a)(1) through (ix), (b), (c) and (d). 

The
only Common Area Operating Expenses to be paid by Lessee that are limited to the increases over the Base Year of 1999 as described in Paragraph 4.2, Insert 4.2 and Paragraph 51 are
Real Property Taxes (Paragraph 10), Insurance (Paragraph 8). Lessor does not provide or pay for the cost of any utilities or janitorial service. 

54.    Lessee
has request a build-out of approximately 650 square feet of storage space above the second floor of the building. In consideration of building this space and the
cost incurred by Lessor, on April 1, 2002 the rent is adjusted per the following schedule. 

	Dates-Month-Year
 
	 	Monthly Rent

	April 1, 2002 to November 30, 2002	 	$25,725.00
	December 1, 2002 to November 30, 2003	 	$26,508.00
	December 1, 2003 to November 30, 2004	 	$27,295.00

	

/s/  BILL URBANO      
 EUS PARTNERS, LESSOR

MR. JOE EARLE, PARTNER

DATE: 3-27-02	
 	

/s/  STEVE MCGOWAN      
 NUVASIVE, INC.

STEVE McGOWAN, CFO

DATE:

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EXHIBIT 10.23    
    

*** Material has been omitted pursuant to a request for confidential treatment.

 
 

Patent Purchase Agreement    
    

        THIS PATENT PURCHASE AGREEMENT ("Agreement") is entered into as of June 21, 2002 ("Effective Date"), by and between NuVasive, Inc., a Delaware
corporation ("Buyer" or "NuVasive") and Dr. Anthony Ross and Dr. Peter Guagliano ("Sellers"). Buyer and Seller agree as follows: 

Recitals  

        1.     Sellers
are the owners of the entire right, title, and interest in and to U.S. Patent Nos. 6,183,518, 6,206,921 and 6,264,659 and US Patent Applications Ser. No.
09/659,807 and 09/990,174 ("Patent Rights") involving compositions and related instrumentation for disc nucleus augmentation, collectively "Disc Augmentation Technology." 

        2.     Subject
to the terms and conditions of this Agreement, Buyer wishes to purchase the Patent Rights from Sellers, and Sellers wish to sell, transfer, and convey the Patent
Rights to Buyer. 

        NOW,
THEREFORE, the parties hereto hereby agree as follows: 

Agreement  

 Section 1

Purchase and Sale of the Patent Rights  

        1.1   Subject
to the terms and conditions of this Agreement, Sellers shall, upon successful completion of Biomechanical Testing of the Disc Augmentation Technology (as
determined in good faith by Buyer), sell, transfer, convey, and assign the Patent Rights to Buyer in consideration of Sellers' receipt, on the Effective Date, of a one-time Patent Purchase
Payment of    ***    and stock options to purchase    ***    shares of Buyer's common stock ("Stock Options") pursuant to its 1998 Stock Option/Stock
Issuance Plan attached hereto as Exhibit A (the "Plan") and subject to the Stock Option Agreement attached hereto as  Exhibit B (the "Option
Agreement") and the Stock Purchase Agreement attached hereto as  Exhibit C (the "Purchase Agreement"). 

        1.2   Said
Stock Options shall include a per-share price of    ***    and shall vest according to the vesting schedule set forth in the Grant
Notice attached hereto as Exhibit D (the "Grant Notice") or until such time as the Biomechanical Testing is successfully completed, at which
point any unvested shares shall become fully vested. 

        1.3   In
the instance the Biomechanical Testing is NOT successfully completed ownership of the Patent Rights shall remain with the Sellers and Sellers shall retain the
one-time Patent Purchase Payment of    ***    and all Stock Options already vested. 

Section 2

Delivery  

        2.1   On
the Effective Date, Buyer will deliver to Sellers the Stock Options and the Patent Purchase Payment as set forth in Section 1.1. 

        2.2   Upon
successful completion of the Biomechanical Testing, Sellers agree to execute and deliver to Buyer an Assignment of Patent Rights substantially in the form of  Exhibit E attached hereto (the
"Assignment Agreement"). 

 

Section 3

Representations, Warranties, and Covenants of Sellers  

        Sellers hereby represent, warrant, and covenant to Buyer as follows: 

        3.1   No Public Market. Sellers understand that no public market now exists for any of the securities issued to Buyer and that
there is no assurance that a public market will ever exist for the Shares. 

        3.2   Authorization. Sellers represent that they have the full right, power, and authority to enter into and perform their
obligations under this Agreement and the Assignment Agreement (collectively, the "Agreements"). Sellers agree that the Agreements, when executed and delivered by Sellers, will constitute valid and
binding conveyances and obligations of Sellers, enforceable in accordance with their terms, subject to the laws of general application relating to bankruptcy, insolvency, and the relief of debtors,
rules of law governing specific performance, injunctive relief, or other equitable remedies. 

        3.3   Consents. Other than filings required by Buyer and compliance with the registration requirements of applicable federal
and state securities laws, or exemptions therefrom, no consent, approval, or authorization of or designation, declaration or filing with any state, federal, or foreign governmental authority, or any
third party, on the part of Sellers is required in connection with the valid execution and delivery of the Agreements by Sellers, and the consummation of the transactions contemplated hereby. 

        3.4   Ownership of the Patent Rights. Sellers are the owners of the entire right, title, and interest in the Patent Rights, and
Sellers have not previously assigned or licensed the Patent Rights (nor will they until the Biomechanical Testing is completed) and are not aware of any infringement issues or adverse claims of
ownership to the Patent Rights. 

Section 4

Buyer's Conditions to Closing  

        Buyer's obligation to purchase the Patent Rights is, at the option of Buyer, subject to fulfillment of the following conditions: 

        4.1   Representations. The representations made by Sellers in Section 3 hereof shall be true and correct when made, and
shall be true and correct on the Effective Date and at the completion of Biomechanical Testing. 

        4.2   Execution and Delivery of Assignment. Upon successful completion of the Biomechanical Testing, Sellers shall have
executed and delivered to Buyer the Assignment Agreement set forth in Exhibit E. 

        4.3   Board Approval. The Board of Directors of Buyer shall have approved the issuance of said Stock Options. 

Section 5

Grant Back of Patent Rights  

        5.1   In
the instance NuVasive fails to introduce a product or composition embodying Disc Augmentation Technology (or related method) within a commercially reasonable time
period, NuVasive agrees to grant the Patent Rights back to Sellers (via an Assignment of Patent Rights substantially in the form as shown in  Exhibit E attached hereto). The determination of
"commercially reasonable time period" shall take into consideration, among other factors, the
amount of time required to obtain FDA clearance to commercialize Disc Augmentation Technology. 

2

 

        5.2   Sellers
agree that, as a precondition to the grant back of Patent Rights of Section 5.1, NuVasive shall be entitled to receive all Stock Options which are
unvested at the time the Patent Rights are granted back to Sellers, to the extent such Stock Options have not yet fully vested based on the successful completion of the Biomechanical Testing pursuant
to Section 1.2. 

Section 6

Miscellaneous  

        6.1   Governing Law; Venue. This Agreement shall be governed in all respects by the laws of the State of California as applied
to contracts made and to be fully performed entirely within the state between residents of California. All disputes arising out of this Agreement shall be subject to the exclusive jurisdiction and
venue of California state courts of San Diego County, California (or, if there is exclusive federal jurisdiction, the United States District Court for the Southern District of California) and the
parties consent to the personal and exclusive jurisdiction and venue of these courts. 

        6.2   Successors and Assigns. Except as otherwise provided herein, the provisions hereof shall inure to the benefit of, and be
binding upon, the successors, assigns, heirs,, executors, and administrators of the parties hereto. 

        6.3   Indemnification by NuVasive. Buyer agrees to indemnify, defend and hold Sellers harmless from any third party liability,
losses, damages, or costs (including reasonable attorneys' fees and costs) arising out of or related to any action arising out of (a) a claim that the manufacture or sale of any Disc
Augmentation Technology violates the patent, trademark, or trade name rights of any third party; (b) any alleged defects or failures to perform of the Disc Augmentation Technology;
(c) any product liability claims or use of the Disc Augmentation Technology; or (d) the advertising, distribution or marketing of the Disc Augmentation Technology. Sellers agree to
assist Buyer in the defense of any such action set forth in 6.3(a) through 6.3(d). 

        6.4   Enforcement. In the event that NuVasive wishes to enforce Patent Rights against a third party infringer, Sellers will
provide reasonable cooperation and assistance in that effort, including being available for witness and deposition testimony, making documents available, and complying with any other reasonable
request. 

        6.5   Insurance. NuVasive agrees to maintain product liability insurance coverage of at least    ***    
per occurrence and to name Drs. Anthony Ross and Peter Guagliano as additional insureds thereunder. 

        6.6   Entire Agreement; Amendment. This Agreement and the other documents delivered pursuant hereto constitute the full and
entire understanding and agreement between the parties with regard to the subjects hereof and thereof and supersede all prior arrangements and understanding with respect hereto. Neither this Agreement
nor any term hereof may be amended, waived, discharged, or terminated other than by a written instrument signed by Buyer and Sellers. 

        6.7   Notices. Any notice or communication required or permitted to be given under this Agreement shall be sufficiently given
when received by certified mail, or by overnight courier, to the parties at the addresses provided below. 

        6.8   Severability. In the event that any provision of this Agreement becomes or is declared by a court of competent
jurisdiction to be illegal, unenforceable, or void, this Agreement shall continue in full force and effect without said provision; provided that no such severability shall be effective if it
materially changes the economic benefit of this Agreement to any party. The foregoing Patent Purchase Agreement is hereby executed by Buyer and Sellers as of the date first above written. 

*** Material has been omitted pursuant to a request for confidential treatment.

3

	Buyer:	 	Sellers:
	NuVasive, Inc.	 	Dr. Anthony C. Ross
	

By:	

/s/ Alexis Lukianov
 ALEXIS V. LUKIANOV

President & CEO

NuVasive, Inc.

10065 Old Grove Road

San Diego, California 92131	
 	

By:	

/s/ Anthony Ross
 ANTHONY C. ROSS

An individual

Anthony C. Ross, D.C.

3546 Maybank Hwy.

John's Island, S.C. 29455
	

Date:	

6-24-02
	
 	

Date:	

6/21/02

	

 	

 	
 	
Dr. Peter A. Guagliano
	

 	

 	
 	

By:	

/s/ Peter Guagliano
 PETER A. GUAGLIANO

An individual

370 Bay Ridge Parkway

Brooklyn, NY 11209
	

 	

 	
 	

Date:	

6/21/02

EXHIBIT A  

 1998 NuVasive Stock Option/Stock Issuance Plan  

        Filed as Exhibit 10.11 to this Registration Statement 

EXHIBIT B  

 NuVasive Stock Option Agreement  

        Filed as Exhibit 10.13 to this Registration Statement 

EXHIBIT C  

 Stock Purchase Agreement  

        Filed as Exhibit 10.14 to this Registration Statement 

EXHIBIT D  

 Grant Notice  

        Filed as Exhibit 10.12 to this Registration Statement 

EXHIBIT E  

 Assignment of Patent Rights  

        In consideration of the mutual obligations set forth in that Patent Purchase Agreement
dated                        by and between NuVasive, Inc. ("NuVasive") and
Drs. Anthony C. Ross and Peter A. Guagliano ("Drs. Ross and Guagliano"), the adequacy and receipt of which is hereby acknowledged, Dr. Ross and Guagliano, owners of the entire right, title, and
interest in and to U.S. Patent Nos. 6,183,518, 6,206,921 and 6,264,659 and US Patent Applications Ser. No. 09/659,807 and 09/990,174 ("Patent Rights") hereby sell and assign to NuVasive the
entire right, title and interest in the Patent Rights, to be held and enjoyed by NuVasive, its successors and assigns, as fully and entirely as the same would have been held and enjoyed by Drs. Ross
and Guagliano had this assignment and sale not been made. 

        In
testimony whereof, Dr. Anthony C. Ross and Dr. Peter A. Guagliano have signed this Assignment of Patent Rights
this                        day
of                        , 2002.
 

                                        
                                          
    

[seal] 

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EXHIBIT 10.23

Patent Purchase Agreement

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