Document:

EX-10.1

 Exhibit 10.1 

AMENDED AND RESTATED EXECUTIVE EMPLOYMENT AGREEMENT 

This Amended and Restated Executive Employment Agreement (the “Agreement”) is entered into as of July 7, 2014
(the “Effective Date”), by and between Julie Anne Smith (“Executive”) and Raptor Pharmaceutical Corp. (the “Company”). 

WHEREAS, the Company and Executive entered into that certain Employment Agreement entered into as of
September 10, 2012 setting forth the terms of Executive’s employment by the Company as its Executive Vice President, Strategy, and Chief Operating Officer (the “Prior Agreement”);  

WHEREAS, Executive is currently employed by Company as its Executive Vice President, Strategy, and Chief
Operating Officer, and Company desires to promote Executive to the position of President and Chief Executive Officer Designate effective as of the Effective Date and to the position of President and Chief Executive Officer effective January 1,
2015, and Executive desires to serve in such capacities, pursuant to the terms and conditions set forth in this Agreement; and 

WHEREAS, Company and Executive intend that the Prior Agreement be superseded in all respects by this
Agreement. 
 NOW, THEREFORE, in consideration of the mutual promises and covenants
contained herein, it is hereby agreed by and between the parties hereto as follows: 
 ARTICLE I 

DEFINITIONS 
 For purposes
of the Agreement, the following terms are defined as follows: 
 1.1. “Board” means the Board of Directors of the Company. 

1.2. “Cause” means any of the following events described below: 

(a) Executive’s commission of a felony or other crime involving moral turpitude; 

(b) any willful act or acts of dishonesty undertaken by Executive and intended to result in substantial gain or personal enrichment of
Executive, Executive’s family or any third party at the expense of the Company; 
 (c) any willful act of gross misconduct which
is materially and demonstrably injurious to the Company; and/or 
 (d) Employee’s inability to lawfully work in the United
States. 
 For the purpose of this Agreement, no act, or failure to act, by Executive shall be considered “willful” if done, or omitted to be
done, by her in good faith and in the reasonable belief that her act or omission was in the best interest of the Company and/or required by applicable law.. 

 1.3. “Change in Control” means the occurrence of any of the following events:
(i) any sale or exchange of the capital stock by the stockholders of the Company in one transaction or series of related transactions where more than fifty percent (50%) of the outstanding voting power of the Company is acquired by a
person or entity or group of related persons or entities; or (ii) any reorganization, consolidation or merger of the Company where the outstanding voting securities of the Company immediately before the transaction represent or are converted
into less than fifty percent (50%) of the outstanding voting power of the surviving entity (or its parent corporation) immediately after the transaction; or (iii) the consummation of any transaction or series of related transactions that
results in the sale of all or substantially all of the assets of the Company; or (iv) any “person” or “group” (as defined in the Securities Exchange Act of 1934, as amended (the “Exchange Act”) becoming the
“beneficial owner” (as defined in Rule 13d-3 under the Exchange Act) directly or indirectly of securities representing more than fifty percent (50%) of the voting power of the Company then outstanding. 

1.4. “Change in Control Multiple” shall mean 1.5 during Executive’s service as President and Chief Executive Officer Designate
and shall mean 2 during Executive’s service as President and Chief Executive Officer. 
 1.5. “Change in Control Period” means
that period commencing on the consummation of a Change in Control and ending on the first anniversary thereof. 
 1.6. “COBRA” means
the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended. 
 1.7. “Code” means the Internal Revenue Code of 1986, as
amended. 
 1.8. “Company” means Raptor Pharmaceutical Corp. or any successor thereto. 

1.9. “Confidential Information Agreement” means the Employee Invention Assignment and Confidentiality Agreement entered into between
Executive and the Company. 
 1.10. “Covered Termination” means (a) an Involuntary Termination Without Cause or (b) a
voluntary termination for Good Reason, provided that the termination constitutes a Separation from Service. 
 1.11. “Good Reason”
means Executive’s resignation as a result of a Good Reason Condition. In order to resign for Good Reason, Executive must provide written notice to the Company of the existence of the Good Reason Condition within thirty (30) days of the
initial existence of such Good Reason Condition. Upon receipt of such notice of the Good Reason Condition, the Company will be provided with a period of thirty (30) days during which it may remedy the Good Reason Condition and not be required
to provide for the payments and benefits described in Section 4 as a result of such proposed resignation due to the Good Reason Condition specified in the notice. If the Good Reason Condition is not remedied within the period specified in the
preceding sentence, Executive may resign for Good Reason based on the Good Reason Condition specified in the notice, provided that such resignation must occur within sixty (60) days after the initial existence of such Good Reason Condition.

  
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 1.12. “Good Reason Condition” means that any of the following are undertaken without
Executive’s express written consent: 
 (a) a material reduction in Executive’s Base Salary (other than as part of a
reduction in the base salary of at least a majority of the Company’s executives of the same or greater percentage); 
 (b) a
material diminution in Executive’s responsibilities; 
 (c) the Company’s material breach of any material term of this
Agreement; or 
 (d) a requirement that Executive relocate to an office that would increase Executive’s one-way commute distance
by more than fifty (50) miles based on Executive’s primary residence at the time such relocation is announced, provided, that this Section 1.10(d) shall only apply after Executive relocates her primary residence to the San Francisco
Bay area as contemplated by Section 2.1 of this Agreement.. 
 1.13. “Involuntary Termination Without Cause” means
Executive’s dismissal or discharge by the Company other than for Cause. The termination of Executive’s employment as a result of Executive’s death or inability to perform the essential functions of her job due to disability will not
be deemed to be an Involuntary Termination Without Cause. 
 1.14. “Separation from Service” means Executive’s termination of
employment or service constitutes a “separation from service” within the meaning of Treasury Regulation Section 1.409A-1(h). 

ARTICLE II 
 EMPLOYMENT
BY THE COMPANY 
 2.1. Position and Duties. Subject to terms set forth herein, as of the Effective Date, Executive shall serve as the
Company’s President and Chief Executive Officer Designate and perform such duties as are customarily associated with the position of President and Chief Executive Officer Designate and such other duties as are assigned to Executive by the
Board. Subject to terms and conditions set forth herein, effective January 1, 2015, Executive shall serve as the Company’s President and Chief Executive Officer and perform such duties as are customarily associated with the position of
President and Chief Executive Officer and such other duties as are assigned to Executive by the Board. During the term of Executive’s employment with the Company, Executive will devote Executive’s best efforts and substantially all of
Executive’s business time and attention (except for vacation periods and reasonable periods of illness or other incapacities permitted by the Company’s general employment policies or as otherwise set forth in this Agreement) to the
business of the Company. As of January 1, 2015, Executive shall be appointed to serve as a member of the Board. Executive shall relocate her primary residence to the San Francisco Bay area no later than January 1, 2015, unless the parties
otherwise agree prior to such date in writing. 
 2.2. Employment at Will. Both the Company and Executive shall have the right to terminate
Executive’s employment with the Company at any time, with or without Cause, and without prior notice. If Executive’s employment with the Company is terminated, Executive will be eligible to receive severance benefits to the extent provided
in this Agreement. 

  
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 2.3. Employment Policies. The employment relationship between the parties shall also be governed by the
general employment policies and practices of the Company, including those relating to protection of confidential information and assignment of inventions, except that when the terms of this Agreement differ from or are in conflict with the
Company’s general employment policies or practices, this Agreement shall control. 
 ARTICLE III 

COMPENSATION 
 3.1. Base Salary. As
of the Effective Date, Executive shall receive for services to be rendered hereunder an annual base salary of $450,000 (“Base Salary”), payable on the regular payroll dates of the Company, subject to increase in the sole discretion
of the Board. Effective January 1, 2015, in connection with Executive’s promotion to President and Chief Executive Officer, Executive’s Base Salary shall be increased to $550,000 and shall remain subject to increase in the sole
discretion of the Board. Executive shall not be entitled to any additional compensation for her services as a member of the Board. 
 3.2. Bonus. As
of the Effective Date, Executive’s annual performance bonus target shall be increased to fifty percent (50%) of Base Salary and shall be prorated for the period beginning on the Effective Date and continuing through December 31, 2014
(the “Annual Bonus”). Effective January 1, 2015, in connection with Executive’s promotion to President and Chief Executive Officer, Executive’s Annual Bonus shall be increased to sixty percent (60%) of Base
Salary. Annual Bonus payments for 2014, as well as for future years, will be determined in the discretion of the Board or a committee of the Board and will be (a) subject to achievement of any applicable bonus objectives and/or conditions
determined by the Board or a committee of the Board, and (b) payable to Executive during the year following the end of the applicable calendar year at the same time as bonuses for other Company executives are paid. In the event that Executive
leads the Company through a transaction or series of transactions that provides significant demonstrable value to the Company’s stockholders, Executive will be eligible for a transaction bonus the amount of which will be determined based on the
contribution of Executive and the value provided and other terms and conditions to be determined by the Board or a committee of the Board. 
 3.3.
Standard Company Benefits. Executive shall continue to be entitled to all rights and benefits for which Executive is eligible under the terms and conditions of the standard Company benefits and compensation practices that may be in effect from
time to time and are provided by the Company to its executive employees generally. Executive shall be entitled each year to four (4) weeks leave for vacation at full pay, provided, that the maximum amount Executive may have accrued at any point
in time is four (4) weeks (meaning that once Executive has accrued four (4) weeks, Executive will not accrue any additional vacation time until she takes vacation and falls below the four (4) week accrual cap). Executive shall also be
entitled to reasonable holidays and illness days with full pay in accordance with the policies applicable to the Company and its affiliates from time to time in effect. Employee acknowledges and agrees that in order to maintain flexibility, the
Company and its affiliates have the right to amend or terminate any employee benefit plan at any time. 

  
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 3.4. Stock Option Awards. Subject to approval by the Board, in connection with Executive’s promotion
to President and Chief Executive Officer Designate, Executive will be granted an option to purchase 175,000 shares of the Company’s common stock with an exercise price equal to the closing price on the day preceding the date of grant. Following
Executive’s promotion to President and Chief Executive Officer, subject to approval by the Board, Executive will be granted an option to purchase 350,000 shares of the Company’s common stock with an exercise price equal to the closing
price on the day preceding the date of grant. Such grant shall be in lieu of an annual fiscal 2015 option grant. Subject to Executive’s continued employment with the Company through each applicable vesting date, each such stock option will vest
with respect to 1/8th of the total number of shares initially subject thereto on the six month anniversary of the applicable promotion date and 1/48th per month on each subsequent monthly anniversary of such date thereafter. Notwithstanding
anything to the contrary contained in this Agreement, such options shall be subject to the terms and conditions of the Company’s 2010 Stock Incentive Plan, as amended from time to time, and the applicable Notice of Grant and Stock Option
Agreement. Executive will be eligible to receive future stock grants and stock option awards at the discretion of the Board. 
 3.5. Expenses. 

(a) Relocation Expenses. The Company will reimburse Executive for reasonable relocation expenses, not to exceed, in the aggregate,
$100,000, which Executive incurs in relocating herself, her family, and her automobile and household goods to the San Francisco Bay area as contemplated by Section 2.1 of this Agreement, provided that Executive submits such expenses for
reimbursement within the normal the Company procedures for the reimbursement of employee business expenses and in accordance with subsection (c) of this Section 3.5. The expenses covered by this Section 3.5(a) are: airfare for
Executive and her family to the San Francisco Bay area for the purposes of house hunting and associated travel and lodging expenses, costs for packing/unpacking and shipping Executive’s household goods and automobiles, temporary lodging
expenses, realtor or other fees or costs associated with selling and/or purchasing a residence and charges to terminate and start any utility services and other similar charges that Executive incurs as the result of her relocation to the San
Francisco Bay area. To the extent that the Company reasonably determines that any such reimbursement will be taxable to Executive, it will pay Executive an additional amount designed to net employee an after tax amount (taking into account the
reimbursement and the additional amount) approximately equal to the amount being reimbursed. For the sake of clarity, any such additional payment shall not count toward the $100,000 limit set forth in this subsection (a). Executive agrees that if
her employment with the Company terminates prior to a Change in Control and other than in connection with a Covered Termination, death or permanent disability, she will promptly reimburse the Company for (i) the full payment she received under
this Section 3.5(a) if such termination occurs prior to the first anniversary of the Effective Date and (ii) 50% of the payment she received under this Section 3.5(a) if such termination occurs following the first anniversary but
prior to the second anniversary of the Effective Date. 

  
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 (b) Commuting Expenses. The Company will reimburse Executive for all reasonable mutually
agreeable commuting expenses (i.e., air transportation, airport transportation, overnight lodging, a reasonable per diem for meals to be agreed between the Company and Executive) associated with her commute from the Summerlin, Nevada area to the San
Francisco Bay area that are directly related to the performance of Executive’s job duties for the Company until the earlier of (i) December 31, 2014 or (ii) the date Executive moves her primary residence to the San Francisco Bay
area, provided that Executive submits such expenses for reimbursement within the time period required by the normal the Company procedures for the reimbursement of employee business expenses and in accordance with subsection (c) of this
Section 3.5. After December 31, 2014 or the date of her move to the San Francisco Bay area, the Company shall not have any further obligation to reimburse Executive such expenses. Executive acknowledges and agrees that any such amounts
that are taxable to Executive shall not be grossed up by the Company. 
 (c) The Company will reimburse Executive for all
reasonable and necessary expenses incurred by Executive in connection with the Company’s business, excluding those expenses described in subsection (a) or (b), above, but including reasonable “business class” airfare for any
flight with a duration of five hours or more one-way, provided that such expenses are in accordance with applicable policies set by the Board from time to time and are properly documented and accounted for in accordance with such policies and with
the requirements of the Internal Revenue Service. 
 (d) The Company shall reimburse Executive for the reasonable
attorneys’ and professional tax fees and related expenses and disbursements incurred by Executive in connection with the negotiation and preparation of this Agreement, in an aggregate amount not to exceed $5,000. 

ARTICLE IV 
 SEVERANCE
AND CHANGE IN CONTROL BENEFITS 
 4.1. Severance Benefits. Upon Executive’s termination of employment, Executive shall receive any accrued
but unpaid Base Salary and other accrued and unpaid compensation, including any Annual Bonus that has been earned with respect to a prior year, but remains unpaid as of the date of the termination. If the termination is due to a Covered Termination
or permanent disability, provided that Executive first returns all Company property in her possession and, within sixty (60) days following the Covered Termination, executes and does not revoke an effective general release of all claims against
the Company and its affiliates in a form reasonably acceptable to the Company (a “Release of Claims”), Executive shall also be entitled to receive the following severance benefits described in this Section 4.1. 

(a) Covered Termination Not Related to a Change in Control. If Executive’s employment terminates due to a Covered Termination
which occurs outside of a Change in Control Period, Executive shall receive the following:  
 (i) An amount equal to twelve
(12) months of Executive’s Base Salary payable in substantially equal installments in accordance with the Company’s normal payroll policies, less applicable withholdings, with such installments to commence as soon as administratively
practicable following the date the Release of Claims is not subject to revocation and, in any event, within sixty (60) days following the date of the Covered Termination. 

  
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 (ii) If Executive elects to receive continued healthcare coverage pursuant to the
provisions of COBRA, the Company shall directly pay, or reimburse Executive for, the premium for Executive and Executive’s covered dependents through the earlier of (i) the first anniversary of the date of Executive’s termination of
employment and (ii) the date Executive and Executive’s covered dependents, if any, become eligible for healthcare coverage under another employer’s plan(s). Notwithstanding the foregoing, (i) if any plan pursuant to which such
benefits are provided is not, or ceases prior to the expiration of the period of continuation coverage to be, exempt from the application of Section 409A of the Code under Treasury Regulation Section 1.409A-1(a)(5), or (ii) the
Company is otherwise unable to continue to cover Executive under its group health plans without penalty under applicable law (including without limitation, Section 2716 of the Public Health Service Act), then, in either case, an amount equal to
each remaining Company subsidy shall thereafter be paid to Executive in substantially equal monthly installments. After the Company ceases to pay premiums pursuant to this Section 4.1(a)(ii), Executive may, if eligible, elect to continue
healthcare coverage at Executive’s expense in accordance the provisions of COBRA. 
 (iii) All of Employee’s vested options
or stock appreciation rights with respect to the Company’s common stock shall remain exercisable until the first anniversary of Executive’s termination of employment (or, if earlier, the maximum period specified in the award documents and
plans governing such options or stock appreciation rights, as applicable, assuming Executive’s employment had not terminated), and all shares of the Company’s common stock owned by Executive shall immediately be released from any and all
resale or repurchase rights restrictions (other than those imposed under applicable law. 
 (iv) the Company shall pay Executive a
lump sum equal to the Adjusted Annual Bonus (for purposes of this subsection (iv), the term “Adjusted Annual Cash Bonus” means the average Annual Bonus Executive received with respect to the two years preceding the year of termination or,
if two Annual Bonus payment dates have not occurred (regardless of whether Executive received an Annual Bonus on such dates) prior to Executive’s termination of employment, the Annual Bonus Executive received with respect to the year preceding
the year of termination, which amount shall be paid on as soon as administratively practicable following the date the Release of Claims is not subject to revocation and, in any event, within sixty (60) days following the date of the Covered
Termination. 
 (b) Covered Termination Related to a Change in Control. If Executive’s employment terminates due to a Covered
Termination that occurs during a Change in Control Period, Executive shall receive the following: 
 (i) Executive shall be
entitled to receive an amount equal to the Change in Control Multiplier multiplied by the sum of: (i) Executive’s Base Salary and (ii) Executive’s target Annual Bonus for the fiscal year of Executive’s termination, in each
case, at the rate equal to the higher of (x) the rate in effect immediately prior to Executive’s termination of employment or (y) the rate in effect immediately prior to the Change in Control payable in a cash lump sum, less
applicable withholdings, as soon as administratively practicable following the date the Release of Claims is not subject to revocation and, in any event, within sixty (60) days following the date of the Covered Termination. 

  
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 (ii) If Executive elects to receive continued healthcare coverage pursuant to the
provisions of COBRA, the Company shall directly pay, or reimburse Executive for, the premium for Executive and Executive’s covered dependents through the earlier of (i) the date that is that number of years equal to the Change in Control
Multiplier following the date of Executive’s termination of employment and (ii) the date Executive and Executive’s covered dependents, if any, become eligible for healthcare coverage under another employer’s plan(s).
Notwithstanding the foregoing, (i) if any plan pursuant to which such benefits are provided is not, or ceases prior to the expiration of the period of continuation coverage to be, exempt from the application of Section 409A of the Code
under Treasury Regulation Section 1.409A-1(a)(5), or (ii) the Company is otherwise unable to continue to cover Executive under its group health plans without penalty under applicable law (including without limitation, Section 2716 of
the Public Health Service Act), then, in either case, an amount equal to each remaining Company subsidy shall thereafter be paid to Executive in substantially equal monthly installments. After the Company ceases to pay premiums pursuant to this
Section 4.1(b)(ii), Executive may, if eligible, elect to continue healthcare coverage at Executive’s expense in accordance the provisions of COBRA. 

(iii) Each outstanding equity award, including, without limitation, each stock option and restricted stock award, held by Executive
shall automatically become vested and, if applicable, exercisable and any forfeiture restrictions or rights of repurchase thereon shall immediately lapse, in each case, with respect to one hundred percent (100%) of the shares subject thereto.
To the extent vested after giving effect to the acceleration provided in the preceding sentence, each stock option held by Executive shall remain exercisable until the earlier of the original expiration date for such stock option or the second
anniversary of Executive’s Covered Termination and all shares of the Company’s common stock owned by Executive shall immediately be released from any and all resale or repurchase restrictions (other than those imposed under applicable
law). 
 (c) Termination for Death or Disability. If Executive’s employment is terminated due to death or permanent disability
where the Company makes a determination in good faith that, due to a mental or physical incapacity, Executive has been unable to perform her duties under this Agreement for a period of not less than six (6) consecutive months or 180 days in the
aggregate in any 12-month period, Executive shall receive the following:  
 (i) An amount equal to six (6) months of
Executive’s Base Salary payable in substantially equal installments in accordance with the Company’s normal payroll policies, less applicable withholdings, with such installments to commence as soon as administratively practicable
following the date the Release of Claims is not subject to revocation and, in any event, within sixty (60) days following the date of the Covered Termination. 

(ii) If Executive (or in the event of death, her designee) elects to receive continued healthcare coverage pursuant to the provisions
of COBRA, the Company shall directly pay, or reimburse Executive for, the premium for Executive and Executive’s covered dependents through the earlier of (i) the six (6) month anniversary of the date of Executive’s termination of

  
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employment and (ii) the date Executive and Executive’s covered dependents, if any, become eligible for healthcare coverage under another employer’s plan(s). Notwithstanding the
foregoing, (i) if any plan pursuant to which such benefits are provided is not, or ceases prior to the expiration of the period of continuation coverage to be, exempt from the application of Section 409A of the Code under Treasury
Regulation Section 1.409A-1(a)(5), or (ii) the Company is otherwise unable to continue to cover Executive under its group health plans without penalty under applicable law (including without limitation, Section 2716 of the Public
Health Service Act), then, in either case, an amount equal to each remaining Company subsidy shall thereafter be paid to Executive in substantially equal monthly installments. After the Company ceases to pay premiums pursuant to this
Section 4.1(b)(ii), Executive may, if eligible, elect to continue healthcare coverage at Executive’s expense in accordance the provisions of COBRA. 

4.2. 280G Provisions. Notwithstanding anything in this Agreement to the contrary, if any payment or distribution Executive would receive pursuant to
this Agreement or otherwise (“Payment”) would (a) constitute a “parachute payment” within the meaning of Section 280G of the Code, and (b) but for this sentence, be subject to the excise tax imposed by
Section 4999 of the Code (the “Excise Tax”), then such Payment shall either be (i) delivered in full, or (ii) delivered as to such lesser extent which would result in no portion of such Payment being subject to the
Excise Tax, whichever of the foregoing amounts, taking into account the applicable federal, state and local income taxes and the Excise Tax, results in the receipt by Executive on an after-tax basis, of the largest payment, notwithstanding that all
or some portion the Payment may be taxable under Section 4999 of the Code. The accounting firm engaged by the Company for general audit purposes as of the day prior to the effective date of the Change in Control shall perform the foregoing
calculations. The Company shall bear all expenses with respect to the determinations by such accounting firm required to be made hereunder. The accounting firm shall provide its calculations to the Company and Executive within fifteen
(15) calendar days after the date on which Executive’s right to a Payment is triggered (if requested at that time by the Company or Executive) or such other time as requested by the Company or Executive. Any good faith determinations of
the accounting firm made hereunder shall be final, binding and conclusive upon the Company and Executive. Any reduction in payments and/or benefits pursuant to this Section 4.2 will occur in the following order: (1) reduction of cash
payments; (2) cancellation of accelerated vesting of equity awards other than stock options; (3) cancellation of accelerated vesting of stock options; and (4) reduction of other benefits payable to Executive. 

4.3. Section 409A. 
 (a)
Notwithstanding any provision to the contrary in this Agreement, if Executive is deemed at the time of her Separation from Service to be a “specified employee” for purposes of Section 409A(a)(2)(B)(i) of the Code, to the extent
delayed commencement of any portion of the benefits to which Executive is entitled under this Agreement is required in order to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code which would subject Executive to a tax
obligation under Section 409A of the Code, such portion of Executive’s benefits shall not be provided to Executive prior to the earlier of (i) the expiration of the six- month period measured from the date of the Executive’s
Separation from Service or (ii) the date of Executive’s death. Upon the expiration of the applicable Code Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Section 4.3(a) shall be paid in a lump sum to
Executive, and any remaining payments due under the Agreement shall be paid as otherwise provided herein. 

  
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 (b) Any reimbursements payable to Executive pursuant to the Agreement shall be paid to
Executive no later than 30 days after Executive provides the Company with a written request for reimbursement, and to the extent that any such reimbursements are deemed to constitute “nonqualified deferred compensation” within the meaning
of Section 409A of the Code (i) such amounts shall be paid or reimbursed to Executive promptly, but in no event later than December 31 of the year following the year in which the expense is incurred, (ii) the amount of any such
payments eligible for reimbursement in one year shall not affect the payments or expenses that are eligible for payment or reimbursement in any other taxable year, and (iii) Executive’s right to such payments or reimbursement shall not be
subject to liquidation or exchange for any other benefit. 
 (c) For purposes of Section 409A of the Code (including,
without limitation, for purposes of Treasury Regulation Section 1.409A-2(b)(2)(iii)), Executive’s right to receive installment payments under the Agreement shall be treated as a right to receive a series of separate payments and,
accordingly, each installment payment hereunder shall at all times be considered a separate and distinct payment. 
 4.4. Mitigation. Executive shall
not be required to mitigate damages or the amount of any payment provided under this Agreement by seeking other employment or otherwise, nor shall the amount of any payment provided for under this Agreement be reduced by any compensation earned by
Executive as a result of employment by another employer or by any retirement benefits received by Executive after the date of the Covered Termination, or otherwise. 

ARTICLE V 
 PROPRIETARY
INFORMATION OBLIGATIONS 
 5.1. Agreement. Executive agrees to continue to abide by the Confidential Information Agreement. 

5.2. Remedies. Executive’s duties under the Confidential Information Agreement shall survive termination of Executive’s employment with the
Company and the termination of this Agreement. Executive acknowledges that a remedy at law for any breach or threatened breach by Executive of the provisions of the Confidential Information Agreement, as well as Executive’s obligations pursuant
to Section 6.2 and Article 7 below, would be inadequate, and Executive therefore agrees that the Company shall be entitled to seek injunctive relief in case of any such breach or threatened breach. 

ARTICLE VI 
 OUTSIDE
ACTIVITIES 
 6.1. Other Activities. 

(a) Except as otherwise provided in Section 6.1(b), Executive shall not, during the term of this Agreement undertake or engage in
any other employment, occupation or business enterprise, other than ones in which Executive is a passive investor, unless she obtains the prior written consent of the Board. 

  
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 (b) Executive may engage in civic and not-for-profit activities so long as such activities
do not materially interfere with the performance of Executive’s duties hereunder. In addition, Executive shall be allowed to serve as a member of the board of directors of up to two (2) other for profit entities at any time during the term
of this Agreement, which service shall not materially interfere with the performance of Executive’s duties hereunder; provided, however, that the Board, in its discretion, may require that Executive resign from one or both of such director
positions if it determines that such resignation(s) would be in the best interests of the Company. 
 6.2. Competition/Investments. During the
term of Executive’s employment by the Company, except on behalf of the Company, Executive shall not directly or indirectly, whether as an officer, director, stockholder, partner, proprietor, associate, representative, consultant, or in any
capacity whatsoever engage in, become financially interested in, be employed by or have any business connection with any other person, corporation, firm, partnership or other entity whatsoever which were known by Executive to compete directly with
the Company, throughout the world, in any line of business engaged in (or planned to be engaged in) by the Company; provided, however, that anything above to the contrary notwithstanding, Executive may own, as a passive investor, securities of any
competitor corporation, so long as Executive’s direct holdings in any one such corporation shall not in the aggregate constitute more than 1% of the voting stock of such corporation. 

ARTICLE VII 

NONINTERFERENCE 
 In
addition to Executive’s obligations under the Confidential Information Agreement, Executive shall not for a period of one (1) year following Executive’s termination of employment for any reason, either on Executive’s own account
or jointly with or as a manager, agent, officer, employee, consultant, partner, joint venturer, owner or stockholder or otherwise on behalf of any other person, firm or corporation, directly or indirectly solicit or attempt to solicit away from the
Company any of its officers or employees or offer employment to any person who is an officer or employee of the Company; provided, however, that a general advertisement to which an employee of the Company responds shall in no event be deemed
to result in a breach of this Article 7. Executive also agrees not to harass or disparage the Company or its employees, clients, directors or agents or divert or attempt to divert any actual or potential business of the Company. The provisions of
this Article 7 shall survive the termination or expiration of the applicable Executive’s employment with the Company and shall be fully enforceable thereafter. If it is determined by a court of competent jurisdiction in any state that any
restriction in this Article 7 is excessive in duration or scope or is unreasonable or unenforceable under the laws of that state, it is the intention of the parties that such restriction may be modified or amended by the court to render it
enforceable to the maximum extent permitted by the law of that state. 

  
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 ARTICLE VIII 

GENERAL PROVISIONS 
 8.1. Notices.
Any notices provided hereunder must be in writing and shall be deemed effective upon the earlier of personal delivery (including personal delivery by facsimile) or the third day after mailing by first class mail, to the Company at its primary office
location and to Executive at Executive’s address as listed on the Company payroll. 
 8.2. Tax Withholding. Executive acknowledges that all
amounts and benefits payable under this Agreement are subject to deduction and withholding to the extent required by applicable law. 
 8.3.
Severability. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any
respect under any applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such
jurisdiction as if such invalid, illegal or unenforceable provisions had never been contained herein. 
 8.4. Waiver. If either party should waive
any breach of any provisions of this Agreement, they shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 

8.5. Complete Agreement. This Agreement constitutes the entire agreement between Executive and the Company and is the complete, final, and exclusive
embodiment of their agreement with regard to this subject matter, and will supersede all prior agreements, understandings, discussions, negotiations and undertakings, whether written or oral, between the parties with respect to the subject matter
hereof, including without limitation, the Prior Agreement. This Agreement is entered into without reliance on any promise or representation other than those expressly contained herein or therein, and cannot be modified or amended except in a writing
signed by an officer of the Company and Executive. 
 8.6. Counterparts. This Agreement may be executed in separate counterparts, any one of which
need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 
 8.7. Headings. The
headings of the sections hereof are inserted for convenience only and shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 

8.8. Successors and Assigns. This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive and the Company, and their
respective successors, assigns, heirs, executors and administrators, except that Executive may not assign her rights or delegate her duties or obligations hereunder without the prior written consent of the Company. 

8.9. Arbitration. Unless otherwise prohibited by law or specified below, all disputes, claims and causes of action, in law or equity, arising from or
relating to this Agreement or its enforcement, performance, breach, or interpretation shall be resolved solely and exclusively by 

  
 12 

 
final and binding arbitration held in Marin County, California through Judicial Arbitration & Mediation Services/Endispute (“JAMS”) in conformity with the then-existing
JAMS employment arbitration rules and California law. The arbitrator shall: (a) provide adequate discovery for the resolution of the dispute; and (b) issue a written arbitration decision, to include the arbitrator’s essential findings
and conclusions and a statement of the award. However, nothing in this section is intended to prevent either party from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration. The Company
shall bear the costs of any such arbitration. 
 8.10. Executive Acknowledgement. Executive acknowledges that (a) she has consulted with or has
had the opportunity to consult with independent counsel of her own choice concerning this Agreement, and has been advised to do so by the Company, and (b) that she has read and understands the Agreement, is fully aware of its legal effect, and
has entered into it freely based on her own judgment. 
 8.11. Choice of Law. All questions concerning the construction, validity and interpretation
of this Agreement will be governed by the law of the State of California without regard to the conflicts of law provisions thereof. 

[Signature page follows] 

  
 13 

 IN WITNESS WHEREOF, the
parties have executed this Agreement as of the date first written above. 
  

			
	RAPTOR PHARMACEUTICAL CORP.
		
	By:	 	  /s/ LLEW KELTNER

		 	LLEW KELTNER, M.D., P.H.D.
		
	Title:	 	Chairman of the Board of Directors

 Accepted and Agreed: 
  

	
	 /s/ JULIE ANNE SMITH

	JULIE ANNE SMITHEX-10.2

 Exhibit 10.2 

TRANSITION AND SEPARATION AGREEMENT 

This Transition and Separation Agreement (the “Agreement”) by and between Christopher M. Starr, Ph.D.
(“Executive”) and Raptor Pharmaceutical Corp., a Delaware corporation (the “Company”), is made effective as of the date Executive signs this Agreement (the “Effective Date”) with reference to the
following facts: 
 A. Executive’s employment with the Company and status as an officer and employee of the Company and each of its
affiliates will end effective upon the Resignation Date (as defined below). 
 B. Executive and the Company want to end their relationship
amicably and also to establish the obligations of the parties including, without limitation, all amounts due and owing to the Executive. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements hereinafter set forth, the parties agree as follows: 

1. Resignation Date. Executive acknowledges and agrees that his status as an officer and employee of the Company and as
an officer of the Company’s subsidiaries will end effective as of December 31, 2014 (the “Resignation Date”). Executive hereby agrees to execute such further document(s) as shall be determined by the Company as necessary
or desirable to give effect to the termination of Executive’s status as an officer of the Company and each of its subsidiaries; provided that such documents shall not be inconsistent with any of the terms of this Agreement. Executive
will continue to serve as a non-employee director on the Board of Directors of the Company (the “Board”) following the Resignation Date. Between the Effective Date through the Resignation Date, Mr. Starr’s employment
agreement with the Company entered into as of May 1, 2006, as amended on January 1, 2009 (the “Employment Agreement”), shall continue in effect. 

2. Transition. Executive acknowledges and agrees that effective July 7, 2014, the Executive Vice President Strategy
and Chief Operational Officer will be promoted to President and Chief Executive Officer Designate with the expectation that she will be appointed Chief Executive Officer on January 1, 2015. 

3. Transition Consulting Services. 

(a) Consulting Period. During the period of time (the “Consulting Period”) commencing on the
Resignation Date and ending on the earlier of the first anniversary of the Resignation Date or the date the Company terminates the services hereunder for Cause (as defined in the Employment Agreement) or Executive terminates the services hereunder
for any reason (the “Consulting Period End Date”), Executive shall be available to provide services to the Company, on a non-exclusive basis, as a consultant and shall provide such transition services (the “Transition
Services”) as necessary in Executive’s areas of expertise and work experience and responsibility as may be requested by the Chief Executive Officer of the Company at times reasonably agreeable to Executive and the Company’s Chief
Executive Officer. During the Consulting Period, Executive will report to the Chief Executive Officer of the Company. Executive acknowledges and agrees that, during the Consulting Period, Executive shall not, directly or indirectly, become employed
by or provide assistance to any competitor of the Company that is involved in drug development for nephropathic cystinosis, nonalcoholic fatty liver disease, Huntington’s disease (HD), and Leigh syndrome or other mitochondrial disease. During
the Consulting 

  
 1 

 
Period, Executive reaffirms his commitment to remain in compliance with that certain Employee Invention Assignment and Confidentiality Agreement entered into between Executive and the Company, as
of May 1, 2006 (the “Confidentiality Agreement”), it being understood that the term “employment” as used in the Confidentiality Agreement shall include the Transition Services during the Consulting Period. Executive
and the Company acknowledge and agree that the intent of the parties hereto is that Executive serve the Company during the Consulting Period at the average rate of not more than eight hours per week. 

(b) Consulting Fees. In exchange for the performance of the Transition Services and subject to continuing compliance by
Executive with the terms of the Confidentiality Agreement, for the Consulting Period, the Company shall pay to Executive monthly consulting fees as an independent contractor (the “Consulting Fees”) in an amount equal to $20,000 per
month. The Consulting Fees will be paid to Executive in accordance with the Company’s standard payment procedures for consultants and independent contractors and will be in addition to fees and other compensation Executive will be entitled to
as a non-employee member of the Board. 
 (c) Benefits. As an independent contractor, Executive understands and agrees
that, while performing any services for the Company after the Resignation Date, Executive shall not be eligible to participate in or accrue benefits under any Company benefit plan for which status as an employee of the Company is a condition of such
participation or accrual. To the extent that Executive were deemed eligible to participate, as an employee, in any Company benefit plan, he hereby waives his participation. 

(d) Stock Options. Until the later of (i) the Consulting Period End Date and (ii) the end of the period
Executive continues to serve as a non-employee director on the Board (through such later date, the “Service Period”), Executive’s options to purchase shares of Company common stock (collectively, “Options”) shall
continue to vest and become exercisable in accordance with their original vesting schedules. At the end of the Service Period, Executive’s unvested equity awards shall be forfeited. 

Options held by Executive that are vested as of the end of the Service Period, other than Options granted to Executive in 2010,
shall remain exercisable until the earlier of (i) eighteen months after Executive’s termination of Continuous Services, or (ii) the original expiration date of the Option. Options held by Executive that are vested as of the end of the
Service Period and that were granted to Executive in 2010 shall be deemed amended to the extent necessary to provide that the vested portion thereof shall remain exercisable until the earlier of (i) twelve months after Executive’s
termination of Continuous Services, and (ii) the original expiration date of the Option. Executive acknowledges that to the extent the Options granted in 2010 constitute “incentive stock options” within the meaning of Section 422
of the Internal Revenue Code of 1986, as amended (the “Code”), they shall be deemed modified for the purposes of Section 424 of the Code and, to the extent the exercise price thereof is lower than the fair market value of the
Company’s common stock as of the date Executive signs this Agreement, such Option shall no longer qualify as incentive stock options and Executive will lose the potentially favorable tax treatment associated with such Options. 

(e) Independent Contractor Status. Executive and the Company acknowledge and agree that, during the Consulting Period,
Executive shall be an independent contractor. During the Consulting Period and thereafter, Executive shall not be an agent or employee of the Company and shall not be authorized to act on behalf of the Company. The

  
 2 

 
Company will not make deductions for taxes from any Consulting Fees paid hereunder. Personal income and self-employment taxes for Consulting Fees paid to Executive hereunder shall be the sole
responsibility of Executive. Executive agrees to indemnify and hold the Company and the other entities released herein harmless for any tax claims or penalties resulting from any failure by Executive to make required personal income and
self-employment tax payments with respect to the Consulting Fees. 
 4. Final Paycheck; Payment of Accrued Wages and
Expenses. 
 (a) Final Paycheck. As soon as administratively practicable on or after the Resignation Date, the
Company will pay Executive all accrued but unpaid base salary and all accrued and unused vacation or other paid time off earned through the Resignation Date, subject to standard payroll deductions and withholdings. Executive is entitled to these
payments regardless of whether Executive executes this Agreement or a Release of Claims (as defined below). 
 (b) Annual
Bonus. The Company shall pay Executive the annual bonus earned by Executive for fiscal year 2014, based on actual performance for fiscal year 2014, payable in a single cash lump sum on the regularly scheduled payment date under the applicable
Company bonus plan or program. Executive is entitled to this payment regardless of whether Executive executes this Agreement or a Release of Claims (as defined below). 

(c) Business Expenses. The Company shall reimburse Executive for all outstanding expenses incurred prior to the
Resignation Date which are consistent with the Company’s policies in effect from time to time with respect to travel and other business expenses, subject to the Company’s requirements with respect to reporting and documenting such
expenses, including, without limitation, expenses incurred pursuant to Executive’s services as a director of any of the Company’s subsidiaries. Executive is entitled to these payments regardless of whether Executive executes this Agreement
or a Release of Claims (as defined below). 
 5. Separation Payments and Benefits. Without admission of any liability,
fact or claim, the Company hereby agrees, subject to Executive delivering to the Company a General Release of Claims substantially in the form attached hereto as Exhibit A (the “Release of Claims”) within twenty-three
(23) days following the Resignation Date and Executive not revoking the Release of Claims within the seven (7)-day period following his execution of such agreement (the “Revocation Period) and Executive’s performance of his continuing
obligations pursuant to this Agreement and the Confidentiality Agreement, to provide Executive the severance benefits set forth below. Specifically, the Company and Executive agree as follows: 

(a) Severance. For the twelve (12)-month period commencing on the Resignation Date (the “Severance
Period”), Executive shall receive the continued payment of his base salary (the aggregate amount for such twelve (12)-month period, $471,500), subject to continuing compliance by Executive with the terms hereof, the Confidentiality
Agreement and the Release of Claims. Such payment shall be made in substantially equal installments on a periodic basis in accordance with the Company’s normal payroll practices; provided, however, that the first payment under this section
shall be made on the first payroll date following the expiration of the Revocation Period without Executive having revoked the Release of Claims and with the first such payment to include any installments not made prior to the expiration of the
Revocation Period. 

  
 3 

 (b) Bonus. The Company shall pay Executive an amount equal to $235,750,
which represents 100% of Executive’s bonus target for fiscal year 2014, less required withholding taxes, such payment to be made in a single cash lump sum no later than ten (10) days following the date that is seven (7) days after the
expiration of the Revocation Period without Executive having revoked the Release of Claims. 
 (c) Healthcare Continuation
Coverage. If Executive elects to receive continued healthcare coverage pursuant to the provisions of the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company shall directly pay, or reimburse
Executive for, that portion of the premium for Executive and Executive’s covered dependents necessary such that Executive contributes the same amount to COBRA coverage as Executive contributed to medical, dental and vision coverage prior to the
date of this Agreement, such payment or reimbursement to continue until the earliest of (i) the end of the Severance Period, (ii) the date Executive becomes eligible for comparable coverage under another employer’s plans or
(iii) the date Executive is no longer eligible for COBRA coverage, provided that Executive submits documentation to the Company substantiating his payments for COBRA coverage. Any such reimbursement payments, if applicable, shall be made to
Executive no later than twenty (20) days after Executive’s submission of documentation to the Company substantiating his payments for COBRA coverage. After the Company ceases to pay premiums pursuant to the preceding sentence, Executive
may, if eligible, elect to continue healthcare coverage at Executive’s expense in accordance with the provisions of COBRA. 

(d) Taxes. Executive understands and agrees that all payments under this Agreement will be subject to appropriate tax
withholding and other deductions. To the extent any taxes may be payable by Executive for the benefits provided to him by this Agreement beyond those withheld by the Company, and to the extent the Company withheld the proper amounts and remitted
them timely to the proper governmental entities, Executive agrees to pay them himself and to indemnify and hold the Company and the other entities released herein harmless for any tax claims or penalties, and associated attorneys’ fees and
costs, resulting from any failure by him to make required payments. To the extent that any reimbursements payable pursuant to this Agreement are subject to the provisions of Section 409A of the Code, such reimbursements shall be paid to
Executive no later than December 31 of the year following the year in which the expense was incurred, the amount of expenses reimbursed in one year shall not affect the amount eligible for reimbursement in any subsequent year, and
Executive’s right to reimbursement under this Agreement will not be subject to liquidation or exchange for another benefit. 

(e) SEC Reporting. Executive acknowledges that to the extent required by the Securities Exchange Act of 1934, as amended
(the “Exchange Act”), he has continuing obligations under Section 16(a) and 16(b) of the Exchange Act to report his transactions in Company common stock while he is serving as a director on the Board and for six (6) months
following the date he ceases to serve as a director on the Board. Executive hereby agrees not to undertake, directly or indirectly, any reportable transactions which include, but are not limited to, buying, selling or otherwise disposing of any
common stock of the Company held by Executive without first preclearing such transaction with the Company’s Chief Compliance Officer until the end of such periods. 

(f) Sole Separation Benefit. Executive agrees that the payments provided by this Section 5 are not required under
the Company’s normal policies and procedures and are provided as a severance solely in connection with this Agreement and the 

  
 4 

 
Release of Claims. Executive acknowledges and agrees that the payments referenced in this Section 5 constitute adequate and valuable consideration, in and of themselves, for the promises
contained in this Agreement and the Release of Claims. 
 6. Full Payment. Executive acknowledges that the payment and
arrangements herein shall constitute full and complete satisfaction of any and all amounts properly due and owing to Executive as a result of his employment with the Company and the termination thereof. Executive further acknowledges that, other
than the Confidentiality Agreement and the Indemnity Agreement between Executive and the Company (the “Indemnification Agreement”) attached as Exhibit B, and the agreements evidencing the Options (the “Option Agreements”),
this Agreement shall supersede each agreement entered into between Executive and the Company regarding Executive’s employment, including, without limitation, any offer letter, employment agreement, severance and/or change in control agreement,
and each such agreement other than the Option Agreements and the Indemnification Agreement shall be deemed terminated and of no further effect as of the Resignation Date. 

7. Executive’s Release of the Company. Executive agrees that the consideration set forth in this Agreement
represents settlement in full of all outstanding obligations owed to Executive by the Company and its current and former officers, directors, employees, agents, investors, attorneys, affiliates, divisions, and subsidiaries, and predecessor and
successor corporations and assigns (collectively, the “Releasees”). 
 (a) Executive, on his own behalf and
on behalf of his family members, heirs, executors, administrators, agents, and assigns, hereby and forever releases the Releasees from, and agrees not to sue concerning, or in any manner to institute, prosecute, or pursue, any claim, complaint,
charge, duty, obligation, or cause of action relating to any matters of any kind, whether presently known or unknown, suspected or unsuspected, that Executive may possess against any of the Releasees arising from any omissions, acts, facts, or
damages that have occurred up until and including the Effective Date of this Agreement, including, without limitation: 

(i) any and all claims relating to or arising from Executive’s employment relationship with Company and the termination
of that relationship; 
 (ii) any and all claims for wrongful discharge of employment; termination in violation of public
policy; discrimination; harassment; retaliation; breach of contract, both express and implied; breach of covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent or intentional infliction of emotional
distress; fraud; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander; negligence; personal injury; assault; battery;
invasion of privacy; false imprisonment; conversion; and disability benefits; 
 (iii) any and all claims for violation of
any federal, state, or municipal statute, including, but not limited to, Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Rehabilitation Act of 1973; the Americans with Disabilities Act of 1990; the Equal Pay Act;
the Fair Labor Standards Act, except as prohibited by law; the Fair Credit Reporting Act; the Age Discrimination in Employment Act of 1967; the Older Workers Benefit Protection Act; the Employee Retirement Income Security Act of 1974; the Worker
Adjustment and Retraining 

  
 5 

 
Notification Act; the Family and Medical Leave Act, except as prohibited by law; the Sarbanes-Oxley Act of 2002, except as prohibited by law; the Uniformed Services Employment and Reemployment
Rights Act; the California Family Rights Act; the California Labor Code, except as prohibited by law; the California Workers’ Compensation Act, except as prohibited by law; and the California Fair Employment and Housing Act; 

(iv) any and all claims for violation of the federal or any state constitution; 

(v) any and all claims arising out of any other laws and regulations relating to employment or employment discrimination; 

(vi) any claim for any loss, cost, damage, or expense arising out of any dispute over the non-withholding or other tax
treatment of any of the proceeds received by Executive as a result of this Agreement; and 
 (vii) any and all claims for
attorneys’ fees and costs. 
 (b) Executive agrees that the release set forth in this section shall be and remain in
effect in all respects as a complete general release as to the matters released. This release does not extend to any obligations incurred under this Agreement, the Option Agreements, or the Indemnification Agreement. This release does not release
claims or rights that cannot be released as a matter of law, including, but not limited to, claims under Division 3, Article 2 of the California Labor Code (which includes California Labor Code section 2802 regarding indemnity for necessary
expenditures or losses by Executive) any other indemnification, defense, or hold-harmless rights Executive may have, and Executive’s right to bring to the attention of the Equal Employment Opportunity Commission or California Department of Fair
Employment and Housing claims of discrimination, harassment or retaliation; provided, however, that Executive does release his right to obtain damages for any such claims. This release does not release claims or rights that the Executive may have as
a shareholder of the Company or for benefits under any benefit plan or to participation in any such plan pursuant to the terms thereof or applicable law. 

(c) Executive acknowledges that he has been advised to consult with legal counsel and is familiar with the provisions of
California Civil Code Section 1542, a statute that otherwise prohibits unknown claims, which provides as follows: 
 A GENERAL RELEASE
DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 

Executive, being aware of said code section, agrees to expressly waive any rights he may have thereunder, as well as under any other statute or
common law principles of similar effect. 

  
 6 

 8. Non-Disparagement, Transition, Transfer of Company Property and Limitations
on Service. Executive further agrees that: 
 (a) Non-Disparagement. Executive agrees that he shall not disparage,
criticize or defame the Company, its affiliates and their respective affiliates, directors, officers, agents, partners, stockholders, employees, products, services, technology or business, either publicly or privately. The Company agrees that it
shall not, and it shall instruct its officers and members of the Board to not, disparage, criticize or defame Executive, either publicly or privately. Nothing in this Section 8(a) shall have application to any evidence or testimony required by
any court, arbitrator or government agency. 
 (b) Transition. Each of the Company and Executive shall use their
respective reasonable efforts to cooperate with each other in good faith to facilitate a smooth transition of Executive’s duties to other executive(s) of the Company. 

(c) Transfer of Company Property. On or before the Resignation Date, Executive shall turn over to the Company all files,
memoranda, records, and other documents, and any other physical or personal property which are the property of the Company and which he has in his possession, custody or control at the Resignation Date; provided that during the Consulting Period,
Executive will continue to keep his cell phone service, email, laptop and other equipment necessary to perform the Transition Services. 

9. Executive Representations. Executive warrants and represents that (a) he has not filed or authorized the filing
of any complaints, charges or lawsuits against the Company or any affiliate of the Company with any governmental agency or court, and that if, unbeknownst to Executive, such a complaint, charge or lawsuit has been filed on his behalf, he will use
reasonable best efforts to immediately cause it to be withdrawn and dismissed, , and (b) he has no known workplace injuries or occupational diseases and has been provided and/or has not been denied any leave requested under the Family and
Medical Leave Act or any similar state law, . 
 10. No Assignment by Executive. Executive warrants and represents
that no portion of any of the matters released herein, and no portion of any recovery or settlement to which Executive might be entitled, has been assigned or transferred to any other person, firm or corporation not a party to this Agreement, in any
manner, including by way of subrogation or operation of law or otherwise. If any claim, action, demand or suit should be made or instituted against the Company or any other Releasee because of any actual assignment, subrogation or transfer by
Executive, Executive agrees to indemnify and hold harmless the Company and all other Releasees against such claim, action, suit or demand, including necessary expenses of investigation, attorneys’ fees and costs. In the event of
Executive’s death, this Agreement shall inure to the benefit of Executive and Executive’s executors, administrators, heirs, distributees, devisees, and legatees. None of Executive’s rights or obligations may be assigned or transferred
by Executive, other than Executive’s rights to payments hereunder, which may be transferred only upon Executive’s death by will or operation of law. 

11. Non-Solicitation. Without limiting the Confidentiality Agreement, Executive hereby agrees that Executive shall not,
at any time during the Consulting Period or within the one (1) year period immediately following the Resignation Date, directly or indirectly, either for himself or on behalf of any other person, recruit or otherwise solicit or induce any
employee or consultant of the Company to terminate its employment or arrangement with the Company, or otherwise change its relationship with the Company. Notwithstanding the foregoing, nothing herein shall prevent Executive from directly or
indirectly hiring any individual who 

  
 7 

 
submits a resume or otherwise applies for a position in response to a publicly posted job announcement or otherwise applies for employment with any person with whom Executive may be associated
absent any violation of Executive’s obligations pursuant to the preceding sentence. 
 12. Governing Law. This
Agreement shall be construed and enforced in accordance with, and the rights of the parties shall be governed by, the laws of the State of California or, where applicable, United States federal law, in each case, without regard to any conflicts of
laws provisions or those of any state other than California. 
 13. Miscellaneous. This Agreement, collectively with
the Confidentiality Agreement, the Indemnification Agreement, the Option Agreements and the form of General Release of Claims attached as Exhibit A hereto comprise the entire agreement between the parties with regard to the subject matter
hereof and supersedes, in their entirety, any other agreements between Executive and the Company with regard to the subject matter hereof. Executive acknowledges that there are no other agreements, written, oral or implied, and that he may not rely
on any prior negotiations, discussions, representations or agreements. This Agreement may be modified only in writing, and such writing must be signed by both parties and recited that it is intended to modify this Agreement. This Agreement may be
executed in separate counterparts, each of which is deemed to be an original and all of which taken together constitute one and the same agreement. The Company shall reimburse Executive for the reasonable attorneys’ and professional tax or
financial advisors’ fees and related expenses and disbursements incurred by Executive in connection with Executive’s separation of employment with the Company and the negotiation and preparation of this Agreement, in an aggregate amount
not to exceed $10,000. 
 14. Company Assignment and Successors. The Company shall assign its rights and obligations
under this Agreement to any successor to all or substantially all of the business or the assets of the Company (by merger or otherwise). This Agreement shall be binding upon and inure to the benefit of the Company and its successors, assigns,
personnel and legal representatives. 
 15. Maintaining Confidential Information. Executive reaffirms his obligations
under the Confidentiality Agreement. Executive acknowledges and agrees that the payments provided in Sections 3 and 5 above shall be subject to Executive’s continued compliance with Executive’s obligations under the Confidentiality
Agreement. 
 16. Executive’s Cooperation. After the Resignation Date, Executive shall cooperate with the
Company and its affiliates, upon the Company’s reasonable request, with respect to any internal investigation or administrative, regulatory or judicial proceeding involving matters within the scope of Executive’s duties and
responsibilities to the Company or its affiliates during his employment with the Company (including, without limitation, Executive being available to the Company upon reasonable notice for interviews and factual investigations, appearing at the
Company’s reasonable request to give testimony without requiring service of a subpoena or other legal process, and turning over to the Company all relevant Company documents which are or may have come into Executive’s possession during his
employment); provided, however, that any such request by the Company shall not be unduly burdensome or interfere with Executive’s personal schedule or ability to engage in gainful employment and the Company shall pay
Executive a mutually agreed upon daily rate for any such cooperation (other than for de minimis amounts of time and testimony under oath) after the Consulting Period and shall reimburse Executive for his actual, reasonable, out-of-pocket expenses
incurred in connection with providing any such cooperation.

  
 8 

 (Signature page(s) follow) 

  
 9 

 IN WITNESS WHEREOF, the undersigned have caused this Transition and Separation Agreement to be
duly executed and delivered as of the date indicated next to their respective signatures below. 
  

					
	DATED: July 7, 2014	 		 	
		
		 	  /s/ Christopher M. Starr

		 	Christopher M. Starr, Ph.D.
		
		 	RAPTOR PHARMACEUTICAL CORP.
			
	DATED: July 7, 2014	 		 	
			
		 	By:	 	 Llew Keltner, M.D., P.h.D.

		 		 	Llew Keltner, M.D., P.h.D.
		 		 	Chairman of the Board of Directors

  
 S-1 

 EXHIBIT A 

GENERAL RELEASE OF CLAIMS 

This General Release of Claims (“Release”) is entered into as of
            , between Christopher M. Starr, Ph.D. (“Executive”) and Raptor Pharmaceutical Corp., a Delaware corporation (the “Company”) (collectively
referred to herein as the “Parties”), effective eight (8) days after Executive’s signature hereto (the “Effective Date”), unless Executive revokes his acceptance of this Release as provided in Paragraph
1(c), below. 
 1. Executive’s Release of the Company. 

(a) Executive, on his own behalf and on behalf of his family members, heirs, executors, administrators, agents, and assigns,
hereby and forever releases the Company and its current and former officers, directors, employees, agents, investors, attorneys, affiliates, divisions, and subsidiaries, and predecessor and successor corporations and assigns (the
“Releasees”) from, and agrees not to sue concerning, or in any manner to institute, prosecute, or pursue, any claim, complaint, charge, duty, obligation, or cause of action relating to any matters of any kind, whether presently
known or unknown, suspected or unsuspected, that Executive may possess against any of the Releasees arising from any omissions, acts, facts, or damages that have occurred up until and including the date Executive signs this Release, including,
without limitation: 
 (i) any and all claims relating to or arising from Executive’s employment relationship with
Company and the termination of that relationship; 
 (ii) any and all claims for wrongful discharge of employment;
termination in violation of public policy; discrimination; harassment; retaliation; breach of contract, both express and implied; breach of covenant of good faith and fair dealing, both express and implied; promissory estoppel; negligent or
intentional infliction of emotional distress; fraud; negligent or intentional misrepresentation; negligent or intentional interference with contract or prospective economic advantage; unfair business practices; defamation; libel; slander;
negligence; personal injury; assault; battery; invasion of privacy; false imprisonment; conversion; and disability benefits; 

(iii) any and all claims for violation of any federal, state, or municipal statute, including, but not limited to,
Title VII of the Civil Rights Act of 1964; the Civil Rights Act of 1991; the Rehabilitation Act of 1973; the Americans with Disabilities Act of 1990; the Equal Pay Act; the Fair Labor Standards Act, except as prohibited by law; the Fair Credit
Reporting Act; the Age Discrimination in Employment Act of 1967; the Older Workers Benefit Protection Act; the Employee Retirement Income Security Act of 1974; the Worker Adjustment and Retraining Notification Act; the Family and Medical Leave Act,
except as prohibited by law; the Sarbanes-Oxley Act of 2002, except as prohibited by law; the Uniformed Services Employment and Reemployment Rights Act; the California Family Rights Act; the California Labor Code, except as prohibited by law; the
California Workers’ Compensation Act, except as prohibited by law; and the California Fair Employment and Housing Act; 

(iv) any and all claims for violation of the federal or any state constitution; 

  
 A-1 

 (v) any and all claims arising out of any other laws and regulations relating to
employment or employment discrimination; 
 (vi) any claim for any loss, cost, damage, or expense arising out of any dispute
over the non-withholding or other tax treatment of any of the proceeds received by Executive as a result of the Transition and Separation Agreement entered into between the Parties as of July 7, 2014 (the “Transition and Separation
Agreement”); and 
 (vii) any and all claims for attorneys’ fees and costs. 

(b) Executive agrees that the release set forth in this section shall be and remain in effect in all respects as a complete
general release as to the matters released. This release does not extend to any obligations incurred under the Transition and Separation Agreement, the Option Agreements, or the Indemnification Agreement (each as defined in the Transition and
Separation Agreement). This release does not release claims or rights that cannot be released as a matter of law, including, but not limited to, claims under Division 3, Article 2 of the California Labor Code (which includes California Labor Code
section 2802 regarding indemnity for necessary expenditures or losses by Executive) any other indemnification, defense, or hold-harmless rights Executive may have, and Executive’s right to bring to the attention of the Equal Employment
Opportunity Commission or California Department of Fair Employment and Housing claims of discrimination, harassment or retaliation; provided, however, that Executive does release his right to obtain damages for any such claims. This release does not
release claims or rights that the Executive may have as a shareholder of the Company or for vested benefits under any benefit plan or to continued participation in any such plan pursuant to the terms thereof or applicable law. 

(c) Acknowledgment of Waiver of Claims under ADEA. Executive acknowledges that he is waiving and releasing any rights he
may have under the Age Discrimination in Employment Act of 1967 (“ADEA”), and that this waiver and release is knowing and voluntary. Executive acknowledges that this waiver and release does not apply to any rights or claims that may
arise under the ADEA after the Effective Date of this Release. Executive acknowledges that the consideration given for this waiver and release is in addition to anything of value to which Executive was already entitled. Executive further
acknowledges that he has been advised by this writing that: (a) he should consult with an attorney prior to executing this Release; (b) he has twenty-one (21) days within which to consider this Release; (c) he has seven
(7) days following his execution of this Release to revoke this Release; (d) this Release shall not be effective until after the revocation period has expired and Executive will not receive the severance benefits provided by Section 5
of the Transition and Separation Agreement; and (e) nothing in this Release prevents or precludes Executive from challenging or seeking a determination in good faith of the validity of this waiver under the ADEA, nor does it impose any
condition precedent, penalties, or costs for doing so, unless specifically authorized by federal law. In the event Executive signs this Release and returns it to the Chief Financial Officer in less than the 21-day period identified above, Executive
hereby acknowledges that he has freely and voluntarily chosen to waive the time period allotted for considering this Release. To revoke his acceptance of this Release, Executive must contactthe Chief Financial Officer by facsimile at 415-382-8002 no
later than 5 p.m. on the 7th day following Executive’s signature of this Release. 

  
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 (d) California Civil Code Section 1542. Executive acknowledges that
he has been advised to consult with legal counsel and is familiar with the provisions of California Civil Code Section 1542, a statute that otherwise prohibits unknown claims, which provides as follows: 

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 
 Executive, being aware of
said code section, agrees to expressly waive any rights he may have thereunder, as well as under any other statute or common law principles of similar effect. 

2. Executive Representations. Executive represents and warrants that: 

(a) To Executive’s knowledge, Executive has returned to the Company all Company property in Executive’s possession
and if he discovers additional Company property in his possession he will promptly return it to the Company; 
 (b) Except as
Executive has informed the Company in writing, Executive is not owed wages, commissions, bonuses or other compensation, other than any payments that become due under Sections 3 and 5 of the Transition and Separation Agreement; 

(c) During the course of Executive’s employment Executive did not sustain any injuries for which Executive might be
entitled to compensation pursuant to worker’s compensation law or Executive has disclosed any injuries of which he is currently, reasonably aware for which he might be entitled to compensation pursuant to worker’s compensation law; 

(d) From the date Executive executed the Transition and Separation Agreement through the date Executive executes this Release,
Executive has not made any disparaging comments about the Company, nor will Executive do so in the future; and 
 (e)
Executive has not initiated any adversarial proceedings of any kind against the Company or against any other person or entity released herein, nor will Executive do so in the future with respect to any claims released hereby, except as specifically
allowed by this Release. 
 3. Maintaining Confidential Information. Executive reaffirms his obligations under that
certain Employee Invention Assignment and Confidentiality Agreement entered into between Executive and the Company, as of May 1, 2006 (the “Confidentiality Agreement”). Executive acknowledges and agrees that the payments
provided in Sections 3 and 5 of the Transition and Separation Agreement shall be subject to Executive’s continued compliance with Executive’s obligations under the Confidentiality Agreement. 

4. Non-Solicitation. Executive reaffirms his obligations pursuant to Section 11 of the Transition and Separation
Agreement. 

  
 A-3 

 5. Cooperation with the Company. Executive reaffirms his obligations to
cooperate with the Company pursuant to Section 16 of the Transition and Separation Agreement. 
 6. Severability.
The provisions of this Release are severable. If any provision is held to be invalid or unenforceable, it shall not affect the validity or enforceability of any other provision. 

7. Choice of Law. This Release shall in all respects be governed and construed in accordance with the laws of the State
of California, including all matters of construction, validity and performance, without regard to conflicts of law principles. 

8. Integration Clause. This Release and the Transition and Separation Agreement, the Confidentiality Agreement,
Indemnification Agreement and the Option Agreements contain the Parties’ entire agreement with regard to the transition and separation of Executive’s employment, and supersede and replace any prior agreements as to those matters, whether
oral or written. This Release may not be changed or modified, in whole or in part, except by an instrument in writing signed by Executive and the Chief Executive Officer of the Company. 

9. Execution in Counterparts. This Release may be executed in counterparts with the same force and effectiveness as
though executed in a single document. Facsimile signatures shall have the same force and effectiveness as original signatures. 

10. Intent to be Bound. The Parties have carefully read this Release in its entirety; fully understand and agree to its
terms and provisions; and intend and agree that it is final and binding on all Parties. 
 (Signature page(s) follow) 

  
 A-4 

 IN WITNESS WHEREOF, and intending to be legally bound, the Parties have executed the foregoing on
the dates shown below. 
  

									
	EXECUTIVE	 	RAPTOR PHARMACEUTICAL CORP.
			
	  
	 		 	  

	Christopher M. Starr, Ph.D.	 		 	By:	 	
		 		 		 	Title:	 	
					
	Date:	 	  
	 		 	Date:	 	  

  
 A-5

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