Document:

EX-10.1

 Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT 

THIS SECURITIES PURCHASE AGREEMENT (this
“Agreement”) is dated as of November 27, 2013, by and among Ignyta, Inc., a Nevada corporation (the “Company”), and each purchaser identified on the signature pages hereto (each, including its
successors and assigns, a “Purchaser” and collectively, the “Purchasers”). 

RECITALS 

A.         The Company and each Purchaser is executing and delivering this
Agreement in reliance upon the exemption from securities registration afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Rule 506 of Regulation D
(“Regulation D”) as promulgated by the United States Securities and Exchange Commission (the “Commission”) under the Securities Act. 

B.         Each Purchaser, severally and not jointly, wishes to purchase, and
the Company wishes to sell, upon the terms and conditions stated in this Agreement, that aggregate number of shares of common stock, par value $0.00001 per share (the “Common Stock”), of the Company, determined as set
forth in Section 2.1(a) and Section 2.1(b) below (which aggregate amount for all Purchasers together shall be collectively referred to herein as the “Shares”). 

C.         The Shares may also be referred to herein as the
“Securities”. 
 D.         The Company has engaged
National Securities Corporation as its exclusive placement agent (the “Placement Agent”) for the offering of the Shares on a “best efforts” basis. 

E.         Contemporaneously with the execution and delivery of this Agreement,
the Purchasers hereunder shall become parties to and bound as Purchasers under that certain Registration Rights Agreement dated November 6, 2013 and attached hereto as Exhibit A (the “Registration Rights
Agreement”), pursuant to which, among other things, the Company will agree to provide certain registration rights with respect to the Shares under the Securities Act and the rules and regulations promulgated thereunder and applicable
state securities laws. 
 NOW, THEREFORE, in consideration of the mutual covenants
contained in this Agreement, and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Company and the Purchasers hereby agree as follows: 

ARTICLE 1 
 DEFINITIONS

 1.1         Definitions. In addition to the terms defined elsewhere in
this Agreement, for all purposes of this Agreement, the following terms shall have the meanings indicated in this Section 1.1: 

“Action” means any action, suit, inquiry, notice of violation, proceeding (including any partial
proceeding such as a deposition) or investigation pending or, to the Company’s Knowledge, threatened in writing (or otherwise) against the Company or any of its properties or any officer, director or employee of the Company as of the date
hereof acting in his or her capacity as an officer, director or employee of the Company before or by any federal, state, county, local or foreign court, arbitrator, governmental or administrative agency, regulatory authority, stock market, stock
exchange or trading facility. 

  
 1. 

 “Affiliate” means, with respect to any Person, any other
Person that, directly or indirectly through one or more intermediaries, Controls, is controlled by or is under common control with such Person, as such terms are used in and construed under Rule 144. With respect to a Purchaser, any investment
fund or managed account that is managed on a discretionary basis by the same investment manager as such Purchaser will be deemed to be an Affiliate of such Purchaser. 

“Business Day” means a day, other than a Saturday or Sunday, on which banks in New York City are open
for the general transaction of business. 
 “Buy-In” has the meaning set forth in
Section 4.1(f). 
 “Buy-In Price” has the meaning set forth in Section 4.1(f). 

“Closing” means the closing of the purchase by the Purchasers listed on Annex A hereto and sale
by the Company of Shares to such Purchasers pursuant to this Agreement on the Closing Date as provided in Section 2.1(a) hereof. 

“Closing Date” means the third (3rd) Trading
Day after the date on which this Agreement has been executed and delivered by all parties hereto or such earlier date as the parties hereto shall mutually agree, unless on such date the conditions set forth in Sections 2.1, 2.2, 5.1 and 5.2
(other than those to be satisfied at the Closing) shall not have been satisfied or waived, in which case the Closing Date shall be on the third (3rd) Trading Day after the date on which the
last to be satisfied or waived of the conditions set forth in Sections 2.1, 2.2, 5.1 and 5.2 (other than those to be satisfied at the Closing) shall have been satisfied or waived. 

“Common Stock” has the meaning set forth in the Recitals, and also includes any securities into which
the Common Stock may hereafter be reclassified or changed. 
 “Company Counsel” means
Morrison & Foerster LLP. 
 “Company Deliverables” has the meaning set forth in
Section 2.2(a). 
 “Company’s Knowledge” means with respect to any statement made to the
knowledge of the Company, that the statement is based upon the actual knowledge of the officers of the Company who, as of the date hereof, have responsibility for the matter or matters that are the subject of the statement. 

“Compliance Certificate” has the meaning set forth in Section 2.2(a)(vi). 

“Control” (including the terms “controlling”,
“controlled” by or “under common control with”) means the possession, direct or indirect, of the power to direct or cause the direction of the management and policies of a Person, whether through the ownership of
voting securities, by contract or otherwise. 
 “Deadline Date” has the meaning set forth in
Section 4.1(f). 
 “Disclosure Materials” has the meaning set forth in Section 3.1(h).

 “Disclosure Schedule” has the meaning set forth in Section 3.1. 

“DTC” has the meaning set forth in Section 4.1(c). 

“Environmental Laws” has the meaning set forth in Section 3.1(l). 

  
 2. 

 “Evaluation Date” has the meaning set forth in
Section 3.1(u). 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended, or any
successor statute, and the rules and regulations promulgated thereunder. 
 “FDA” has the meaning
set forth in Section 3.1(o). 
 “GAAP” means U.S. generally accepted accounting principles, as
applied by the Company. 
 “Indemnified Person” has the meaning set forth in Section 4.9(b).

 “Intellectual Property” has the meaning set forth in Section 3.1(r). 

“Irrevocable Transfer Agent Instructions” means, with respect to the Company, the Irrevocable Transfer
Agent Instructions, in the form of Exhibit B, executed by the Company and delivered to and acknowledged in writing by the Transfer Agent. 

“Lien” means any material lien, charge, claim, encumbrance, security interest, right of first refusal,
preemptive right or other restrictions of any kind. 
 “Material Adverse Effect” means a material
adverse effect on the results of operations, assets, business or financial condition of the Company, except that any of the following, either alone or in combination, shall not be deemed a Material Adverse Effect: (i) effects caused by changes
or circumstances affecting general market conditions in the U.S. economy or which are generally applicable to the industry in which the Company operates provided that such effects are not borne disproportionately by the Company, (ii) effects
resulting from or relating to the announcement or disclosure of the sale of the Securities or other transactions contemplated by this Agreement, or (iii) effects caused by any event, occurrence or condition resulting from or relating to the
taking of any action in accordance with this Agreement. 
 “Material Contract” means any contract of
the Company that has been filed as an exhibit to the SEC Reports pursuant to Item 601(b)(4) or Item 601(b)(10) of Regulation S-K (including, for purposes hereof, any contracts that are required to be filed as an exhibit to a Form 10).

 “Material Permits” has the meaning set forth in Section 3.1(p). 

“New York Courts” means the state and federal courts sitting in the City of New York, Borough of
Manhattan. 
 “Outside Date” means November 30, 2013 (subject to extension upon mutual
agreement by the Company and the Placement Agent until no later than December 26, 2013). 

“Person” means an individual, corporation, partnership, limited liability company, trust, business
trust, association, joint stock company, joint venture, sole proprietorship, unincorporated organization, governmental authority or any other form of entity not specifically listed herein. 

“Principal Trading Market” means the Trading Market on which the Common Stock is primarily listed on
or quoted for trading, which, as of the date of this Agreement and the Closing Date, shall be the OTC Bulletin Board. 

“Prior Financings” has the meaning set forth in Section 3.2(q). 

  
 3. 

 “Press Release” has the meaning set forth in
Section 4.7. 
 “Proceeding” means an action, claim, suit, investigation or proceeding
(including, without limitation, an investigation or partial proceeding, such as a deposition), whether commenced or threatened. 

“Purchase Price” means $6.00 per share of Common Stock. 

“Purchaser Deliverables” has the meaning set forth in Section 2.2(b). 

“Purchaser Party” has the meaning set forth in Section 4.9(a). 

“Registration Statement” means a registration statement meeting the requirements set forth in the
Registration Rights Agreement and covering the resale by the Purchasers of the Registrable Securities (as defined in the Registration Rights Agreement). 

“Required Approvals” has the meaning set forth in Section 3.1(e). 

“Reverse Merger Transaction” means the transaction whereby the Company (f.k.a. Infinity Oil &
Gas Company) issued a certain number of shares of Common Stock in exchange for 100% of the ownership interest of Ignyta Operating, Inc. Upon completion of the Reverse Merger Transaction, Ignyta Operating, Inc. became a direct wholly-owned Subsidiary
of the Company. 
 “Rule 144” means Rule 144 promulgated by the Commission pursuant to the
Securities Act, as such Rule may be amended from time to time, or any similar rule or regulation hereafter adopted by the Commission having substantially the same effect as such Rule. 

“SEC Reports” has the meaning set forth in Section 3.1(h). 

“Secretary’s Certificate” has the meaning set forth in Section 2.2(a)(vi). 

“Short Sales” include, without limitation, (i) all “short sales” as defined in
Rule 200 promulgated under Regulation SHO under the Exchange Act, whether or not against the box, and all types of direct and indirect stock pledges, forward sale contracts, options, puts, calls, short sales, swaps, “put equivalent
positions” (as defined in Rule 16a-1(h) under the Exchange Act) and similar arrangements (including on a total return basis), and (ii) sales and other transactions through non-U.S. broker dealers or foreign regulated brokers. 

“Stock Certificates” has the meaning set forth in Section 2.2(a)(iv). 

“Subscription Amount” has the meaning set forth in Section 2.1(a). 

“Subscription Booklet” means the Omnibus Signature Page and Purchaser Questionnaire provided by the
Placement Agent to each Purchaser for completion and execution in connection with the issuance and sale of Shares hereunder. 

“Subsidiary” means any entity in which the Company, directly or indirectly, owns capital stock or
holds an equity or similar interest. 
 “Trading Affiliate” has the meaning set forth in
Section 3.2(h). 

  
 4. 

 “Trading Day” means (i) a day on which the Common
Stock is listed or quoted and traded on its Principal Trading Market (unless the Principal Trading Market is the OTC Bulletin Board or the “pink sheets”), or (ii) if the Common Stock is not listed on a Trading Market (other than the
OTC Bulletin Board or the OTC QB, OTC QX or “pink sheets” tier of the OTC Markets Group, Inc.), a day on which the Common Stock is traded in the over-the-counter market, as reported by the OTC Bulletin Board, or (iii) if the Common
Stock is not quoted on any Trading Market (other than the OTC QB, OTC QX or “pink sheets” tier of the OTC Markets Group, Inc.), a day on which the Common Stock is quoted in the over-the-counter market as reported by the OTC QB, OTC QX or
“pink sheets” tier of the OTC Markets Group, Inc. (or any similar organization or agency succeeding to its functions of reporting prices); provided, that in the event that the Common Stock is not listed or quoted as set forth in
(i), (ii) and (iii) hereof, then Trading Day shall mean a Business Day. 
 “Trading
Market” means whichever of the New York Stock Exchange, the NYSE-MKT, the Nasdaq Global Select Market, the Nasdaq Global Market, the Nasdaq Capital Market, the OTC Bulletin Board, the OTC QB, OTC QX or “pink sheets” tier of
the OTC Markets Group, Inc. (or any similar organization or agency succeeding to its functions of reporting prices) on which the Common Stock is listed or quoted for trading on the date in question. 

“Transaction Documents” means this Agreement, the Registration Rights Agreement, the annexes and
exhibits attached hereto and thereto, the Irrevocable Transfer Agent Instructions and any other documents or agreements executed in connection with the transactions contemplated hereunder. 

“Transfer Agent” means Olde Monmouth Stock Transfer Co., Inc., or any successor transfer agent for the
Company. 
 “Unlegended Certificate” has the meaning set forth in Section 4.1(f). 

ARTICLE 2 
 PURCHASE AND
SALE 
 2.1       Closing. 

  (a)         Amount. Subject to the terms and conditions set forth
in this Agreement, at the Closing, the Company shall issue and sell to each Purchaser listed on Annex A hereto, and each Purchaser listed on Annex A hereto shall, severally and not jointly, purchase from the Company, such number of
Shares of Common Stock equal to the quotient resulting from dividing (i) the aggregate purchase price for such Purchaser, as indicated below such Purchaser’s name on its signature page of this Agreement (the “Subscription
Amount”) by (ii) the Purchase Price, rounded down to the nearest whole Share. 
   (b)
        Minimum and Maximum Subscription Amount. Notwithstanding anything to the contrary in this Agreement, (i) no Purchaser shall purchase hereunder, and the Company shall not issue and sell to any
Purchaser hereunder, (A) less than three thousand (3,000) Shares for a Subscription Amount of eighteen thousand dollars ($18,000), or (B) more than ten thousand (10,000) Shares for a Subscription Amount of sixty thousand dollars
($60,000), subject in each case to waiver by the Company in its sole discretion, and (ii) the aggregate number of Shares issued and sold to all Purchasers hereunder shall not be (X) less than five hundred thousand (500,000) Shares for
an aggregate Subscription Amount of all Purchasers hereunder of three million dollars ($3,000,000), or (Y) more than one million one hundred fifty thousand (1,150,000) Shares, for an aggregate Subscription Amount of all Purchasers of six
million nine hundred thousand dollars ($6,900,000), subject to increase upon the exercise of the Placement Agent’s over-allotment option to no more than one million three hundred thousand (1,300,000) Shares for an aggregate Subscription
Amount of all Purchasers of seven million eight hundred thousand dollars ($7,800,000). 

  
 5. 

   (c)         Closing.
The Closing of the purchase and sale of the Shares shall take place at the offices of Company Counsel, 12531 High Bluff Drive, Suite 100, San Diego, California on the Closing Date or at such other locations or remotely by facsimile transmission or
other electronic means as the parties may mutually agree. 
   (d)
        Form of Payment. On the Closing Date, (i) each Purchaser listed on Annex A hereto shall wire its Subscription Amount, in United States dollars and in immediately available funds, in the
amount set forth as the “Aggregate Purchase Price (Subscription Amount)” indicated below such Purchaser’s name on the applicable signature page hereto by wire transfer to the Company’s account, as set forth in instructions
previously provided to the Purchasers, and (ii) the Company shall irrevocably instruct the Transfer Agent to deliver to each Purchaser listed on Annex A hereto one or more stock certificates, free and clear of all restrictive and other
legends except as expressly provided in Section 4.1(b) hereof, evidencing the number of Shares such Purchaser is purchasing as is calculated in accordance with Section 2.1(a) above, within six (6) Business Days after the Closing. 

2.2       Closing Deliveries.  

  (a)         On or prior to the Closing with respect to the
Purchasers listed on Annex A hereto, the Company shall issue, deliver or cause to be delivered to such Purchaser the following (the “Company Deliverables”): 

    (i)          this Agreement, duly executed by the
Company; 
     (ii)         a legal opinion of Company
Counsel dated as of the Closing Date and addressed to such Purchasers; 
     (iii)
        the Registration Rights Agreement, duly executed by the Company; 

    (iv)         a copy of the duly executed Irrevocable
Transfer Agent Instructions delivered to and acknowledged in writing by the Transfer Agent relating to the issuance of stock certificates, free and clear of all restrictive and other legends except as provided in Section 4.1(b) hereof,
evidencing the Shares subscribed for by the Purchasers hereunder, to be registered in the names provided by the Purchasers as set forth in Section 1 of the Subscription Booklet (the “Stock Certificates”) delivered to the
Company pursuant to Section 2.2(b)(iv), with the original Stock Certificates to be delivered to the addresses provided by the Purchasers in such Subscription Booklet within six (6) Business Days following the Closing; provided,
however that the copy of the Irrevocable Transfer Agent Instructions and all attachments thereto delivered to Purchasers in compliance with this Section 2.2(a)(iv) shall be redacted to exclude the mailing address and tax identification
number of each such Purchaser. 
     (v)         a
certificate of the Secretary of the Company (the “Secretary’s Certificate”), dated as of the Closing Date, (a) certifying the resolutions adopted by the Board of Directors of the Company or a duly authorized
committee thereof approving the transactions contemplated by this Agreement and the other Transaction Documents and the issuance of the Securities, (b) certifying the current versions of the certificate of incorporation, as amended, and bylaws
of the Company and (c) certifying as to the signatures and authority of persons signing the Transaction Documents and related documents on behalf of the Company, in the form attached hereto as Exhibit C; 

  
 6. 

     (vi)       a
certificate (the “Compliance Certificate”), dated as of the Closing Date and signed by the Company’s Chief Executive Officer or its Chief Financial Officer, certifying to the fulfillment of the conditions specified in
Sections 5.1(a) and (b) in the form attached hereto as Exhibit D. 
     (vii)
      a certificate evidencing the formation and good standing of the Company issued by the Secretary of State of the State of Nevada, as of a date within five (5) days of the Closing Date; 

    (viii)       a certificate evidencing the Company’s
qualification as a foreign corporation and good standing issued by the Secretary of State of the State of California, as of a date within ten (10) days of the Closing Date; and 

    (ix)       a certified copy of the Certificate of Incorporation,
as certified by the Secretary of State of the State of Nevada, as of a date within ten (10) days of the Closing Date. 

(b)         On or prior to the Closing with respect to the Purchasers listed
on Annex A hereto, each Purchaser shall deliver or cause to be delivered to the Company the following (the “Purchaser Deliverables”): 

    (i)       this Agreement, duly executed by such Purchaser by its
execution and delivery of the Omnibus Signature Page included in the Subscription Booklet; 

    (ii)       its Subscription Amount, in United States dollars and
in immediately available funds, by wire transfer to the Company’s account as previously provided to the Purchasers; and 

    (iii)       a Subscription Booklet that is fully completed and
duly executed by the Purchaser in all respects in accordance with the instructions set forth in the Subscription Booklet. 
 ARTICLE 3

 REPRESENTATIONS AND WARRANTIES 

3.1       Representations and Warranties of the Company. The Company hereby represents
and warrants as of the date hereof and the Closing Date (except for the representations and warranties that speak as of a specific date, which shall be made as of such date), to each of the Purchasers that, except as disclosed in the SEC Reports and
the disclosure schedules delivered by the Company hereunder (the “Disclosure Schedules”), which shall be deemed a part hereof and shall qualify any representations made by the Company herein to the extent of the applicable
disclosure: 
   (a)         Subsidiaries. The Company has no
direct or indirect Subsidiaries other than Ignyta Operating, Inc., a Delaware corporation. 
   (b)
        Organization and Qualification. The Company is an entity duly incorporated, validly existing and in good standing under the laws of the State of Delaware, with the requisite corporate power and
authority to own or lease and use its properties and assets and to carry on its business as currently conducted. The Company is not in violation of any of the provisions of its certificate of incorporation or bylaws. The Company is duly qualified to
conduct business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except where the failure to be so
qualified or in good standing, as the case may be, would not have a Material Adverse Effect. 

  
 7. 

   (c)         Authorization;
Enforcement; Validity. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated by each of the Transaction Documents to which it is a party and otherwise to carry out its
obligations hereunder and thereunder. The execution and delivery of each of the Transaction Documents to which it is a party by the Company and the consummation by it of the transactions contemplated hereby and thereby (including, but not limited
to, the sale and delivery of the Shares) have been duly authorized by all necessary corporate action on the part of the Company, and no further corporate action is required by the Company, its Board of Directors or its stockholders in connection
therewith other than in connection with the Required Approvals. Each of the Transaction Documents to which it is a party has been (or upon delivery will have been) duly executed by the Company and is, or when delivered in accordance with the terms
hereof, will, constitute the legal, valid and binding obligation of the Company enforceable against the Company in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium, liquidation or similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies or by other equitable principles of general application or insofar as indemnification and contribution provisions may
be limited by applicable law. There are no shareholder agreements, voting agreements, or other similar arrangements with respect to the Company’s capital stock to which the Company is a party or, to the Company’s Knowledge, between or
among any of the Company’s stockholders. 
   (d)         No
Conflicts. The execution, delivery and performance by the Company of the Transaction Documents to which it is a party and the consummation by the Company of the transactions contemplated hereby or thereby (including, without limitation, the
issuance of the Shares) do not and will not (i) conflict with or violate any provisions of the Company’s certificate of incorporation or bylaws or otherwise result in a violation of the organizational documents of the Company,
(ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties or assets of the Company or give to others any
rights of termination, amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any Material Contract or (iii) subject to the Required Approvals, result in a violation of any law, rule, regulation, order,
judgment, injunction, decree or other restriction of any court or governmental authority to which the Company is subject (including federal and state securities laws and regulations and the rules and regulations, assuming the correctness of the
representations and warranties made by the Purchasers herein, of any self regulatory organization to which the Company or its securities are subject, including all applicable Trading Markets), or by which any property or asset of the Company is
bound or affected), except in the case of clause (ii) and clause (iii) such as would not individually have a Material Adverse Effect. 

  (e)         Filings, Consents and Approvals. The Company is not
required to obtain any consent, waiver, authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other Person in connection with the
execution, delivery and performance by the Company of the Transaction Documents (including the issuance of the Securities), other than (i) the filing with the Commission of one or more Registration Statements in accordance with the requirements
of the Registration Rights Agreement, (ii) filings required by applicable state securities laws, (iii) the filing of a Notice of Sale of Securities on Form D with the Commission under Regulation D of the Securities Act,
(iv) the filing of any requisite notices and/or application(s) to the Principal Trading Market for the issuance and sale of the Shares and the listing of the Shares for trading or quotation, as the case may be, thereon in the time and manner
required thereby, (v) the filings required in accordance with Section 4.7 of this Agreement and (vi) those that have been made or obtained prior to the date of this Agreement (collectively, the “Required
Approvals”). 

  
 8. 

   (f)         Issuance of
the Securities. The Shares have been duly authorized and, when issued and paid for in accordance with the terms of the Transaction Documents, will be duly and validly issued, fully paid and nonassessable and free and clear of all Liens suffered
or permitted by the Company, other than restrictions on transfer provided for in the Transaction Documents or imposed by applicable securities laws, and shall not be subject to preemptive or similar rights. Assuming the accuracy of the
representations and warranties of the Purchasers in this Agreement, the Shares will be issued in compliance with all applicable federal and state securities laws. 

  (g)         Capitalization. The number of shares and type of all
authorized, issued and outstanding capital stock, options and other securities of the Company (whether or not presently convertible into or exercisable or exchangeable for shares of capital stock of the Company) has been set forth in the SEC Reports
and has changed since the date set forth in the most recently filed of the SEC Reports only to reflect stock option exercises and grants and warrant exercises and grants that have not, individually or in the aggregate, had a material affect on the
issued and outstanding capital stock, options and other securities of the Company. All of the outstanding shares of capital stock of the Company are duly authorized, validly issued, fully paid and non-assessable, have been issued in compliance in
all material respects with all applicable federal and state securities laws, and none of such outstanding shares was issued in violation of any preemptive rights or similar rights to subscribe for or purchase any capital stock of the Company. Except
as set forth in the SEC Reports: (i) no shares of the Company’s capital stock are subject to preemptive rights or any other similar rights or any Liens suffered or permitted by the Company; (ii) except for the Transaction Documents or
as a result of the performance by the Company of the Transaction Documents, there are no outstanding options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible
into, or exercisable or exchangeable for, any shares of capital stock of the Company, or contracts, commitments, understandings or arrangements by which the Company is or may become bound to issue additional shares of capital stock of the Company or
options, warrants, scrip, rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities or rights convertible into, or exercisable or exchangeable for, any shares of capital stock of the Company;
(iii) there are no outstanding debt securities, notes, credit agreements, credit facilities or other agreements, documents or instruments evidencing indebtedness of the Company or by which the Company is or may become bound; (iv) there are
no financing statements securing obligations in any material amounts, either singly or in the aggregate, filed in connection with the Company; (v) there are no agreements or arrangements under which the Company is obligated to register the sale
of any of their securities under the Securities Act (except the Registration Rights Agreement); (vi) there are no outstanding securities or instruments of the Company or which contain any redemption or similar provisions, and there are no
contracts, commitments, understandings or arrangements by which the Company is or may become bound to redeem a security of the Company; (vii) there are no securities or instruments containing anti-dilution or similar provisions that will be
triggered by the issuance of the Securities; (viii) the Company does not have any stock appreciation rights or “phantom stock” plans or agreements or any similar plan or agreement; and (ix) the Company has no liabilities or
obligations required to be disclosed in the SEC Reports (including, for purposes hereof, any liabilities that are required to be disclosed in a Form 10) but not so disclosed in the SEC Reports, other than those incurred in the ordinary course of the
Company’s businesses and which, individually or in the aggregate, do not or would not have a Material Adverse Effect. 

  (h)         SEC Reports. The Company has filed all reports,
schedules, forms, statements and other documents required to be filed by it under the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for twelve (12) months preceding and including the date hereof (or such shorter
period as the Company was required by law or regulation to file such material), including without limitation, that certain Current Report on Form 8-K filed with the Commission on or before the date hereof disclosing, among other things, the
completion of the Reverse Merger Transaction and the Company ceasing to be a “shell company” as defined in Rule 12b-2 under the Exchange Act (the foregoing materials, including the exhibits thereto and documents incorporated by reference
therein, being 

  
 9. 

 
collectively referred to herein as the “SEC Reports” and together with this Agreement, including the Disclosure Schedules hereto, the “Disclosure
Materials”), on a timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. As of the date hereof, the Company has no Knowledge of any event
occurring on or prior to the Closing Date (other than the transactions contemplated by the Transaction Documents) that requires the filing of a Current Report on Form 8-K after the Closing. 

  (i)         Financial Statements. The financial statements of the
Company included in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing. Such financial statements have been
prepared in accordance with GAAP applied on a consistent basis during the periods involved, except as may be otherwise specified in such financial statements or the notes thereto and except that unaudited financial statements may not contain all
footnotes required by GAAP, and fairly present in all material respects the financial position of the Company and its consolidated Subsidiaries taken as a whole as of and for the dates thereof and the results of operations and cash flows for the
periods then ended, subject, in the case of unaudited statements, to normal, year-end audit adjustments. 

  (j)         Tax Matters. The Company (i) has prepared and
filed all foreign, federal and state income and all other tax returns, reports and declarations required by any jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in
amount, shown or determined to be due on such returns, reports and declarations, except those being contested in good faith, with respect to which adequate reserves have been set aside on the books of the Company and (iii) has set aside on its
books provisions reasonably adequate for the payment of all taxes for periods subsequent to the periods to which such returns, reports or declarations apply, except where the failure to so pay or file or set aside provisions for any such tax,
assessment, charge or return would not have a Material Adverse Effect. 
   (k)
        Material Changes. Since the date of the latest financial statements included within the SEC Reports, except as specifically disclosed in the SEC Reports, (i) there have been no events,
occurrences or developments that have had or would reasonably be expected to have a Material Adverse Effect, (ii) the Company has not incurred any material liabilities (contingent or otherwise) other than (A) trade payables, accrued
expenses and other liabilities incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or to be disclosed in filings
made with the Commission, (iii) the Company has not materially altered its method of accounting or the manner in which it keeps its accounting books and records, (iv) the Company has not declared or made any dividend or distribution of
cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock (other than in connection with repurchases of unvested stock issued to employees of the Company),
(v) the Company has not issued any equity securities to any officer, director or Affiliate, except Common Stock issued in the ordinary course pursuant to existing Company stock option or stock purchase plans or executive and director corporate
arrangements disclosed in the SEC Reports and (vi) there has not been any material change or amendment to, or any waiver of any material right under, any Material Contract under which the Company or any of its assets is bound or subject. Except
for the issuance of the Securities contemplated by this Agreement, no event, liability or development has occurred or exists with respect to the Company or its business, properties, operations or financial condition that would be required to be
disclosed by the Company under applicable securities laws at the time this representation is made that has not been publicly disclosed in the SEC Reports. 

  (l)         Environmental Matters. To the Company’s Knowledge,
the Company (i) is not in violation of any statute, rule, regulation, decision or order of any governmental agency or body or any court, domestic or foreign, relating to the use, disposal or release of hazardous or toxic substances or

  
 10. 

 
relating to the protection or restoration of the environment or human exposure to hazardous or toxic substances (collectively, “Environmental Laws”), (ii) does not
own or operate any real property contaminated with any substance that is in violation of any Environmental Laws, (iii) is not liable for any off-site disposal or contamination pursuant to any Environmental Laws, and (iv) is not subject to
any claim relating to any Environmental Laws; which violation, contamination, liability or claim has had or would have a Material Adverse Effect; and there is no pending or, to the Company’s Knowledge, threatened investigation that might lead
to such a claim. 
   (m)         Litigation. There is no Action
which (i) adversely affects or challenges the legality, validity or enforceability of any of the Transaction Documents or the Securities, (ii) involves a claim of violation of or liability under any federal, state, local or foreign laws
governing the Company’s operations, including without limiting the generality of the foregoing, laws regulating the protection of human health, including without limiting the generality of the foregoing, laws relating to the manufacture,
processing, packaging, labeling, marketing, distribution, use, inspection, treatment, storage, disposal, transport or handling of the Company’s products, and regulated or hazardous substances, as well as all authorizations, codes, decrees,
demands or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits, plans or regulations issued, entered, promulgated or approved thereunder, all as may be in effect from time to time and all successors,
replacements and expansions thereof, (iii) involves injury to or death of any person arising from or relating to any of the Company’s product or (iv) could, if there were an unfavorable decision, have a Material Adverse Effect. The
Commission has not issued any stop order or other order suspending the effectiveness of any registration statement filed by the Company under the Exchange Act or the Securities Act. 

  (n)         Employment Matters. No material labor dispute exists
or, to the Company’s Knowledge, is imminent with respect to any of the employees of the Company which would have a Material Adverse Effect. None of the Company’s employees is a member of a union that relates to such employee’s
relationship with the Company, and the Company is not a party to a collective bargaining agreement, and the Company believes that its relationship with its employees is good. 

  (o)         Compliance. The Company (i) is not in default
under or in violation of (and no event has occurred that has not been waived that, with notice or lapse of time or both, would result in a default by the Company), nor has the Company received written notice of a claim that it is in default under or
that it is in violation of, any indenture, loan or credit agreement or any other Material Contract (whether or not such default or violation has been waived), (ii) is not in violation of any order of any court, arbitrator or governmental body
having jurisdiction over the Company or its properties or assets and (iii) is not and has not been in violation of, or in receipt of notice that it is in violation of, any statute, rule or regulation of any governmental authority applicable to
the Company, including without limitation, all applicable rules and regulations of the Food and Drug Administration (the “FDA”), and all applicable laws, statutes, ordinances, rules or regulations (including, without
limitation, the Federal Food, Drug and Cosmetic Act of 1938, as amended and similar foreign laws and regulations) enforced by the FDA or equivalent foreign authorities, except in each case as would not, individually or in the aggregate, have a
Material Adverse Effect. 
   (p)         Regulatory Permits. The
Company possesses all certificates, authorizations and permits issued by the appropriate federal, state, local or foreign regulatory authorities necessary to conduct its business as described in the SEC Reports, including without limitation the FDA,
except where the failure to possess such permits has not had and would not have a Material Adverse Effect (“Material Permits”), and (i) the Company has not received any notice of proceedings relating to the revocation or
modification of any such Material Permits and (ii) the Company has no Knowledge of any facts or circumstances that the Company would reasonably expect to give rise to the revocation or modification of any Material Permits. 

  
 11. 

   (q)         Title to
Assets. The Company does not own any real property. The Company has good and marketable title to all tangible personal property owned by it which is material to the business of the Company, in each case free and clear of all Liens except such as
do not materially affect the value of such property and do not materially interfere with the use made and proposed to be made of such property by the Company and except for Liens for the payment of federal, state or other taxes for which appropriate
reserves have been made in accordance with GAAP and the payment of which is not delinquent or subject to penalties. Any real property and facilities held under lease by the Company are held by it under valid, subsisting and enforceable leases with
such exceptions as are not material and do not interfere with the use made of such property and buildings by the Company. 

  (r)         Intellectual Property. To the Company’s Knowledge,
the Company or its Subsidiaries owns, possesses, licenses or has other rights to use all foreign and domestic patents, patent applications, trade and service marks, trade and service mark registrations, trade names, copyrights, licenses, inventions,
trade secrets, technology and other proprietary rights and processes (collectively, the “Intellectual Property”) necessary for the conduct of its businesses as now conducted and which the failure to so own, possess, license
or have other rights to use would not have a Material Adverse Effect. Except where any such violations or infringements would not have a Material Adverse Effect, to the Company’s Knowledge (i) the Company’s or its Subsidiaries’
use of any such Intellectual Property in the conduct of its business as presently conducted does not infringe upon the rights of any third parties; (ii) there is no infringement by third parties of any such Intellectual Property;
(iii) there is no pending or threatened Action challenging the Company’s rights in or to any such Intellectual Property; (iv) there is no pending or threatened Action challenging the validity or scope of any such Intellectual
Property; and (v) there is no pending or threatened Action that the Company infringes or otherwise violates any patent, trademark, copyright, trade secret or other proprietary rights of others. 

  (s)         Insurance. The Company is insured by insurers of
recognized financial responsibility against such losses and risks and in such amounts as the Company believes to be prudent in the businesses and locations in which the Company is engaged. The Company has not received any notice of cancellation of
any such insurance, nor does the Company have any Knowledge that it will be unable to renew its existing insurance coverage for the Company as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to
continue its business without a significant increase in cost. 
   (t)
        Transactions With Affiliates and Employees. None of the officers or directors of the Company and, to the Company’s Knowledge, none of the employees of the Company, is presently a party to any
transaction with the Company or to a presently contemplated transaction (other than for services as employees, officers and directors) that would be required to be disclosed pursuant to Item 404 of Regulation S-K promulgated under the
Securities Act, except as contemplated by the Transaction Documents or set forth in the SEC Reports. 
   (u)
        Internal Accounting Controls. The Company’s certifying officers have evaluated the effectiveness of the disclosure controls and procedures of the Company as of the end of the period covered by
the most recently filed periodic report under the Exchange Act (such date, the “Evaluation Date”). The Company presented in its most recently filed periodic report under the Exchange Act the conclusions of the certifying
officers about the effectiveness of the disclosure controls and procedures based on their evaluations as of the Evaluation Date. Since the Evaluation Date, there have been no changes in the internal control over financial reporting (as such term is
defined in the Exchange Act) of the Company that have adversely materially affected, or are reasonably likely to adversely materially affect, the internal control over financial reporting of the Company. 

  
 12. 

   (v)
        Sarbanes-Oxley; Disclosure Controls. The Company is in compliance in all material respects with all of the provisions of the Sarbanes-Oxley Act of 2002 which are applicable to it. 

  (w)        Certain Fees. Other than the Placement Agent, no person or
entity will have, as a result of the transactions contemplated by this Agreement, any valid right, interest or claim against or upon the Company or a Purchaser for any commission, fee or other compensation pursuant to any agreement, arrangement or
understanding entered into by or on behalf of the Company. The Company shall indemnify, pay, and hold each Purchaser harmless against, any liability, loss or expense (including, without limitation, attorneys’ fees and out-of-pocket expenses)
arising in connection with any such right, interest or claim. 
   (x)
        Private Placement. Assuming the accuracy of the Purchasers’ representations and warranties set forth in Section 3.2 of this Agreement (without giving effect to any materiality qualifiers
therein) and the accuracy of the information disclosed by each Purchaser in the Accredited Investor Questionnaires delivered pursuant to Section 2.2(b)(iv) and Section 5.2(d), no registration under the Securities Act is required for the
offer and sale of the Securities by the Company to the Purchasers under the Transaction Documents. 
   (y)
        Registration Rights. Other than each of the Purchasers, no Person has any right to cause the Company to effect the registration under the Securities Act of any securities of the Company other than
those securities which are currently registered on an effective registration statement on file with the Commission. 

  (z)         No Directed Selling Efforts or General Solicitation.
Neither the Company nor any Person acting on its behalf has conducted any “general solicitation” or “general advertising” (as those terms are used in Regulation D) in connection with the offer or sale of any of the
Securities. 
   (aa)       No Integrated Offering. Assuming the accuracy of
the Purchasers’ representations and warranties set forth in Section 3.2 (without giving effect to any materiality qualifiers therein), except as disclosed in the SEC Reports and except for the Prior Financings, neither the Company nor any
Person acting on its behalf has, directly or indirectly, at any time within the past six (6) months, made any offers or sales of any Company security or solicited any offers to buy any security under circumstances that would (i) eliminate
the availability of the exemption from registration under Regulation D under the Securities Act in connection with the offer and sale by the Company of the Securities as contemplated hereby or (ii) cause the offering of the Securities
pursuant to the Transaction Documents to be integrated with prior offerings by the Company for purposes of any applicable law, regulation or shareholder approval provisions, including, without limitation, under the rules and regulations of any
Trading Market on which any of the securities of the Company are listed or designated. 
   (bb)
      Listing and Maintenance Requirements. The Company’s Common Stock is registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and the Company has taken no action designed to terminate the
registration of the Common Stock under the Exchange Act nor has the Company received any notification that the Commission is contemplating terminating such registration. 

  (cc)       Investment Company. The Company is not required to be registered
as, and is not an Affiliate of, and immediately following the Closing will not be required to register as, an “investment company” within the meaning of the Investment Company Act of 1940, as amended. 

  (dd)      Application of Takeover Protections; Rights Agreements. The Company and
its board of directors have taken all necessary action, if any, in order to render inapplicable any control share acquisition, business combination, poison pill (including any distribution under a rights agreement)

  
 13. 

 
or, except as disclosed in the SEC Reports, other similar anti-takeover provision under the Company’s charter documents or the laws of the State of Nevada that is or could reasonably be
expected to become applicable to any of the Purchasers as a result of the Purchasers and the Company fulfilling their obligations or exercising their rights under the Transaction Documents, including, without limitation, the Company’s issuance
of the Securities and the Purchasers’ ownership of the Securities. The Company has not adopted a stockholder rights plan or similar arrangement relating to accumulations of beneficial ownership of Common Stock or a change in control of the
Company. 
   (ee)       Off Balance Sheet Arrangements. There is no
transaction, arrangement, or other relationship between the Company and an unconsolidated or other off balance sheet entity that is required to be disclosed by the Company in its SEC Reports (including, for purposes hereof, any that are required to
be disclosed in a Form 10) and is not so disclosed or that otherwise would have a Material Adverse Effect. 

  (ff)       Acknowledgment Regarding the Purchasers’ Purchase of
Securities. The Company acknowledges and agrees that each of the Purchasers is acting solely in the capacity of an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated thereby. The Company
further acknowledges that no Purchaser is acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with respect to the Transaction Documents and the transactions contemplated thereby and any advice given by any
Purchaser or any of their respective representatives or agents in connection with the Transaction Documents and the transactions contemplated thereby is merely incidental to the Purchasers’ purchase of the Securities. 

  (gg)       Foreign Corrupt Practices. Neither the Company, nor to the
Company’s Knowledge, any agent or other person acting on behalf of the Company, has: (i) directly or indirectly, used any funds for unlawful contributions, gifts, entertainment or other unlawful expenses related to foreign or domestic
political activity, (ii) made any unlawful payment to foreign or domestic government officials or employees or to any foreign or domestic political parties or campaigns from corporate funds, (iii) failed to disclose fully any contribution
made by the Company (or made by any person acting on its behalf of which the Company is aware) which is in violation of law or (iv) violated in any material respect any provision of the Foreign Corrupt Practices Act of 1977, as amended. 

  (hh)       No Additional Agreements. The Company does not have any agreement
or understanding with any Purchaser with respect to the transactions contemplated by the Transaction Documents other than as specified in the Transaction Documents. 

3.2       Representations and Warranties of the Purchasers. Each Purchaser hereby,
for itself and for no other Purchaser, represents and warrants as of the date hereof and as of the Closing Date in the case of the Purchasers listed on Annex A hereto to the Company as follows: 

  (a)         Organization; Authority. Such Purchaser is an entity
duly organized, validly existing and in good standing under the laws of the jurisdiction of its organization with the requisite corporate, partnership, limited liability company or other similar power and authority to enter into and to consummate
the transactions contemplated by the Transaction Documents to which it is a party and otherwise to carry out its obligations hereunder and thereunder. The execution, delivery and performance by such Purchaser of the transactions contemplated by this
Agreement have been duly authorized by all necessary corporate or, if such Purchaser is not a corporation, such partnership, limited liability company or other applicable like action, on the part of such Purchaser. Each Transaction Document to which
it is a party has been duly executed by such Purchaser, and when delivered by such Purchaser in accordance with the terms hereof, will constitute the valid and legally binding obligation of such Purchaser, enforceable against it in accordance with
its terms, except as such enforceability may be limited by 

  
 14. 

 
applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws relating to, or affecting generally the enforcement of, creditors’ rights and remedies or by other
equitable principles of general application or insofar as indemnification and contribution provisions may be limited by applicable law. 

  (b)         No Conflicts. The execution, delivery and performance
by such Purchaser of the Transaction Documents to which it is a party and the consummation by such Purchaser of the transactions contemplated hereby and thereby will not (i) result in a violation of the organizational documents of such
Purchaser, (ii) conflict with, or constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any
agreement, indenture or instrument to which such Purchaser is a party or (iii) result in a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws) applicable to such Purchaser, except in
the case of clauses (ii) and (iii) above, for such conflicts, defaults, rights or violations which would not, individually or in the aggregate, reasonably be expected to have a material adverse effect on the ability of such Purchaser to
perform its obligations hereunder. 
   (c)         Investment
Intent. Such Purchaser understands that the Securities are “restricted securities” and have not been registered under the Securities Act or any applicable state securities law and is acquiring the Securities as principal for its own
account and not with a view to, or for distributing or reselling such Securities or any part thereof in violation of the Securities Act or any applicable state securities laws, provided, however, that by making the representations herein,
such Purchaser does not agree to hold any of the Securities for any minimum period of time and reserves the right, subject to the provisions of this Agreement and the Registration Rights Agreement, at all times to sell or otherwise dispose of all or
any part of such Securities pursuant to an effective registration statement under the Securities Act or under an exemption from such registration and in compliance with applicable federal and state securities laws. Such Purchaser is acquiring the
Securities hereunder in the ordinary course of its business. Such Purchaser does not presently have any agreement, plan or understanding, directly or indirectly, with any Person to distribute or effect any distribution of any of the Securities (or
any securities which are derivatives thereof) to or through any person or entity; such Purchaser is not a registered broker-dealer under Section 15 of the Exchange Act or an entity engaged in a business that would require it to be so registered
as a broker-dealer. 
   (d)        Purchaser Status. At the time such
Purchaser was offered the Securities, it was, and at the date hereof it is, an “accredited investor” as defined in Rule 501(a) under the Securities Act. 

  (e)        General Solicitation. Such Purchaser is not purchasing the
Securities as a result of any advertisement, article, notice or other communication regarding the Securities published in any newspaper, magazine or similar media or broadcast over television or radio or presented at any seminar or any other general
advertisement. 
   (f)         Experience of Such Purchaser. Such
Purchaser, either alone or together with its representatives, has such knowledge, sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Securities,
and has so evaluated the merits and risks of such investment. Such Purchaser is able to bear the economic risk of an investment in the Securities and, at the present time, is able to afford a complete loss of such investment. 

  (g)         Access to Information. Such Purchaser acknowledges that
it has had the opportunity to review the Disclosure Materials and has been afforded (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and
conditions of the offering of the Securities and the merits and risks of investing in the Securities; (ii) access to information about the Company and its respective financial condition, 

  
 15. 

 
results of operations, business, properties, management and prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that
the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed investment decision with respect to the investment. Neither such inquiries nor any other investigation conducted by or on behalf of
such Purchaser or its representatives or counsel shall modify, amend or affect such Purchaser’s right to rely on the truth, accuracy and completeness of the Disclosure Materials and the Company’s representations and warranties contained in
the Transaction Documents (as qualified by the Disclosure Materials). Such Purchaser has sought such accounting, legal and tax advice as it has considered necessary to make an informed decision with respect to its acquisition of the Securities. 

  (h)         Certain Trading Activities. Other than with respect to
the transactions contemplated herein, since the time that such Purchaser was first contacted by the Company or any other Person regarding the transactions contemplated hereby, neither the Purchaser nor, to the knowledge of such Purchaser, any
Affiliate of such Purchaser which (i) had knowledge of the transactions contemplated hereby, (ii) has or shares discretion relating to such Purchaser’s investments or trading or information concerning such Purchaser’s
investments, including in respect of the Securities and (iii) is subject to such Purchaser’s review or input concerning such Affiliate’s investments or trading (collectively, “Trading Affiliates”) has
directly or indirectly, nor has any Person acting on behalf of or pursuant to any understanding with such Purchaser or Trading Affiliate, effected or agreed to effect any transactions in the securities of the Company (including, without limitation,
any Short Sales involving the Company’s securities). Notwithstanding the foregoing, in the case of a Purchaser and/or Trading Affiliate that is, individually or collectively, a multi-managed investment vehicle whereby separate portfolio
managers manage separate portions of such Purchaser’s or Trading Affiliate’s assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of such
Purchaser’s or Trading Affiliate’s assets, the representation set forth above shall apply only with respect to the portion of assets managed by the portfolio manager(s) that have knowledge about the financing transaction contemplated by
this Agreement. Other than to other Persons party to this Agreement, such Purchaser has maintained the confidentiality of all disclosures made to it in connection with the transactions contemplated hereby (including the existence and terms of such
transactions). Notwithstanding the foregoing, and except as otherwise provided in Section 4.12, no Purchaser makes any representation, warranty or covenant hereby that it will not engage in Short Sales in the securities of the Company after the
effectiveness of the Registration Statement as described in Section 4.12. 
   (i)
        Brokers and Finders. Other than the Placement Agent, no Person will have, as a result of the transactions contemplated by this Agreement, any valid right, interest or claim against or upon the
Company or any Purchaser for any commission, fee or other compensation pursuant to any agreement, arrangement or understanding entered into by or on behalf of such Purchaser. 

  (j)         Independent Investment Decision. Such Purchaser has
independently evaluated the merits of its decision to purchase Securities pursuant to the Transaction Documents, and such Purchaser confirms that it has not relied on the advice of any other Purchaser’s business and/or legal counsel in making
such decision. Such Purchaser understands that nothing in this Agreement or any other materials presented by or on behalf of the Company to the Purchaser in connection with the purchase of the Securities constitutes legal, tax or investment advice.
Such Purchaser has consulted such legal, tax and investment advisors as it, in its sole discretion, has deemed necessary or appropriate in connection with its purchase of the Securities. 

  (k)         Reliance on Exemptions. Such Purchaser understands that
the Securities are being offered and sold to it in reliance on specific exemptions from the registration requirements of United States federal and state securities laws and that the Company is relying in part upon the truth and accuracy of, and such
Purchaser’s compliance with, the representations, warranties, agreements, acknowledgements and understandings of such Purchaser set forth herein in order to determine the availability of such exemptions and the eligibility of such Purchaser to
acquire the Securities. 

  
 16. 

   (l)         No
Governmental Review. Such Purchaser understands that no United States federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability
of the investment in the Securities nor have such authorities passed upon or endorsed the merits of the offering of the Securities. 

  (m)        Regulation M. Such Purchaser is aware that the
anti-manipulation rules of Regulation M under the Exchange Act may apply to sales of Common Stock and other activities with respect to the Common Stock by the Purchasers. 

  (n)         Residency. Such Purchaser’s principal executive
offices are in the jurisdiction set forth immediately below such Purchaser’s name on the applicable signature page attached hereto. 

  (o)         Trading Market. Such Purchaser acknowledges that the
Securities are quoted over-the-counter, and that no securities issued by the Company are listed on a national securities exchange. 

  (p)         Shell Company. Such Purchaser acknowledges that the
Company may be deemed to be a “shell company” as defined by the rules and regulations of the Commission. 

  (q)         Prior Financings. Such Purchaser acknowledges that the
Company has sold and issued shares of Common Stock and/or securities exercisable for or convertible into Common Stock in the aggregate amount of up to fifty-three million dollars ($53,000,000) within one hundred eighty (180) days prior to the
Closing Date in one or more financings (the “Prior Financings”). 
 The Company and each of the
Purchasers acknowledge and agree that no party to this Agreement has made or makes any representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in this Article III and the
Transaction Documents. 
 ARTICLE 4 

OTHER AGREEMENTS OF THE PARTIES 

4.1         Transfer Restrictions. 

  (a)         Compliance with Laws. Notwithstanding any other
provision of the Transaction Documents, each Purchaser covenants that the Securities may be disposed of only pursuant to an effective registration statement under, and in compliance with the requirements of, the Securities Act, or pursuant to an
available exemption from, or in a transaction not subject to, the registration requirements of the Securities Act, and in compliance with any applicable state and federal securities laws. In connection with any transfer of the Securities other than
(i) pursuant to an effective registration statement, (ii) to the Company, (iii) to an Affiliate of a Purchaser, (iv) pursuant to Rule 144 (provided that the Purchaser provides the Company with reasonable assurances
(in the form of seller and broker representation letters if required) that the securities may be sold pursuant to such rule) or Rule 144A, (v) pursuant to Rule 144 without the requirement that the Company be in compliance with the
current public information requirements of Rule 144 and without other restriction following the applicable holding period or (vi) in connection with a bona fide pledge, the Company may require the transferor thereof to provide to the
Company an opinion of counsel selected by the transferor and reasonably acceptable to the Company, the form and substance of which opinion shall be reasonably satisfactory to the Company, to the effect that

  
 17. 

 
such transfer does not require registration of such transferred Securities under the Securities Act. As a condition of transfer, any such transferee shall agree in writing to be bound by the
terms of this Agreement and shall have the rights of a Purchaser under this Agreement and the Registration Rights Agreement. 

  (b)         Legends. Certificates evidencing the Securities shall
bear any legend as required by the “Blue Sky” laws of any state and a restrictive legend in substantially the following form until such time as they are not required under Section 4.1(c) (and a stock transfer order may be placed
against transfer of the certificates for the Securities): 
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR
THE SECURITIES UNDER THE SECURITIES ACT OR (B) AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL
OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY. 
 In addition, if any Purchaser is an Affiliate of the Company,
certificates evidencing the Securities issued to such Purchaser shall bear a customary “affiliates” legend. 

  (c)         Removal of Legends. Subject to the Company’s right
to request an opinion of counsel as set forth in Section 4.1(a), the legend set forth in Section 4.1(b) above shall be removable and the Company shall issue or cause to be issued a certificate without such legend or any other legend
(except for any “affiliates” legend as set forth in Section 4.1(b)) to the holder of the applicable Shares upon which it is stamped or issue or cause to be issued to such holder by electronic delivery at the applicable balance account
at The Depository Trust Company (“DTC”) as provided in this Section 4.1(c), if (i) such Securities are registered for resale under the Securities Act (provided that, if the Purchaser is selling pursuant to the
effective registration statement registering the Securities for resale, the Purchaser agrees to only sell such Securities during such time that such registration statement is effective and not withdrawn or suspended, and only as permitted by such
registration statement), (ii) such Securities are sold or transferred in compliance with Rule 144 (if the transferor is not an Affiliate of the Company), including without limitation in compliance with the current public information
requirements of Rule 144 if applicable to the Company at the time of such sale or transfer, and the holder and its broker have delivered customary documents reasonably requested by the Transfer Agent and/or Company Counsel in connection with such
sale or transfer, or (iii) such Securities are eligible for sale under Rule 144 without the requirement that the Company be in compliance with the current public information requirements of Rule 144 and without other restriction and Company
Counsel has provided written confirmation of such eligibility to the Transfer Agent. Any fees (with respect to the Transfer Agent, Company Counsel or otherwise) associated with the removal of such legend shall be borne by the Company. Following the
Effective Date (as defined in the Registration Rights Agreement), or at such other time as a legend is no longer required for certain Securities, the Company will no later than three (3) Trading Days following the delivery by a Purchaser to the
Company or the Transfer Agent (with concurrent notice and delivery of copies to the Company) of a legended certificate representing such Shares (endorsed or with stock powers attached, signatures guaranteed, and otherwise in form necessary to affect
the reissuance and/or transfer, and together with such other customary documents as the Transfer Agent and/or Company Counsel shall reasonably request), deliver or cause to be delivered to the transferee of such Purchaser or such Purchaser, as
applicable, a certificate representing such Securities that is free from all restrictive and other legends. The Company may not make any notation on its records or give instructions to the Transfer Agent that

  
 18. 

 
enlarge the restrictions on transfer set forth in this Section 4.1. Certificates for Shares subject to legend removal hereunder shall be transmitted by the Transfer Agent to the Purchasers,
as applicable, by crediting the account of the transferee’s Purchaser’s prime broker with DTC. 

  (d)         Irrevocable Transfer Agent Instructions. The Company
shall issue irrevocable instructions to its Transfer Agent, and any subsequent Transfer Agent, in the form of Exhibit B attached hereto (the “Irrevocable Transfer Agent Instructions”). The Company represents and
warrants that no instruction other than the Irrevocable Transfer Agent Instructions or instructions consistent therewith or otherwise contemplated hereby or thereby or by the other Transaction Documents or such other documents as the Transfer Agent
may request in connection with any such instructions will be given by the Company to its Transfer Agent in connection with this Agreement, and that the Securities shall otherwise be freely transferable on the books and records of the Company as and
to the extent provided in and subject to the terms of this Agreement, the other Transaction Documents and applicable law. 

  (e)         Acknowledgement. Each Purchaser hereunder acknowledges
its primary responsibilities under the Securities Act and accordingly will not sell or otherwise transfer the Shares or any interest therein without complying with the requirements of the Securities Act. While the Registration Statement remains
effective, each Purchaser hereunder may sell the Shares in accordance with the plan of distribution contained in the Registration Statement and, if it does so, it will comply therewith and with the related prospectus delivery requirements unless an
exemption therefrom is available. Each Purchaser, severally and not jointly with the other Purchasers, agrees that if it is notified by the Company in writing at any time that the Registration Statement registering the resale of the Shares is not
effective or that the prospectus included in such Registration Statement no longer complies with the requirements of Section 10 of the Securities Act, the Purchaser will refrain from selling such Shares until such time as the Purchaser is
notified by the Company that such Registration Statement is effective or such prospectus is compliant with Section 10 of the Securities Act, unless such Purchaser is able to, and does, sell such Shares pursuant to an available exemption from
the registration requirements of Section 5 of the Securities Act. Each Purchaser acknowledges that the delivery of the Irrevocable Transfer Agent Instructions and any removal of any legends from certificates representing the Shares as set forth
in this Section 4.1 is predicated on the Company’s reliance upon the Purchaser’s acknowledgement in this Section 4.1(e). 

  (f)         Buy-In. If the Company shall fail for any reason or for
no reason to issue to a Purchaser a certificate not bearing the legend set forth in Section 4.1(b) within three (3) Trading Days after receipt by the Company and the Transfer Agent of all documents necessary for the removal of the legend
as set forth in Section 4.1(c) (the “Deadline Date”) (such certificate, the “Unlegended Certificate”), then, in addition to all other remedies available to such Purchaser, if on or after the
Trading Day immediately following such three (3) Trading Day period, such Purchaser purchases (in an open market transaction or otherwise) shares of Common Stock to deliver in satisfaction of a sale by such Purchaser of the shares of Common
Stock to be represented by the Unlegended Certificate that such Purchaser anticipated receiving from the Company without any restrictive legend as a result of such Purchaser’s full compliance with Section 4.1(c) (a
“Buy-In”), then the Company shall, within three (3) Trading Days after such Purchaser’s request and in such Purchaser’s sole discretion, either (i) pay cash to the Purchaser in an amount equal to such
Purchaser’s total purchase price (including brokerage commissions, if any) for the shares of Common Stock so purchased (the “Buy-In Price”), at which point the Company’s obligation to deliver such certificate (and
to issue such shares of Common Stock) shall terminate, or (ii) promptly honor its obligation to deliver to such Purchaser a certificate or certificates representing such shares of Common Stock and pay cash to the Purchaser in an amount equal to
the excess (if any) of the Buy-In Price over the product of (a) such number of shares of Common Stock, times (b) the closing price of the Common Stock on the Deadline Date as reported by the Principal Trading Market. The Purchaser of
shares of Common Stock shall provide the Company written notice indicating the amounts payable to such Purchaser in respect of the Buy-In, together with applicable confirmations and other evidence reasonably requested by the Company. 

  
 19. 

 4.2         Acknowledgment of
Dilution. The Company acknowledges that the issuance of the Securities may result in dilution of the outstanding shares of Common Stock. The Company further acknowledges that its obligations under the Transaction Documents, including without
limitation its obligation to issue the Shares pursuant to the Transaction Documents, are, subject to the terms and conditions expressly set forth in this Agreement, unconditional and absolute and not subject to any right of set off, counterclaim,
delay or reduction, regardless of the effect of any such dilution or any claim the Company may have against any Purchaser and regardless of the dilutive effect that such issuance may have on the ownership of the other stockholders of the Company.

 4.3         [Intentionally Omitted.] 

4.4         Furnishing of Information. In order to enable the Purchasers to
sell the Securities under Rule 144 of the Securities Act, for a period of one year from the Closing Date, the Company shall use its commercially reasonable efforts to timely file (or obtain extensions in respect thereof and file within the
applicable grace period) all reports required to be filed by the Company after the date hereof pursuant to the Exchange Act. During such one year period, if the Company is not required to file reports pursuant to such laws, it will prepare and
furnish to the Purchasers and make publicly available in accordance with Rule 144(c) such information as is required for the Purchasers to sell the Shares under Rule 144. 

4.5         Form D and Blue Sky. The Company agrees to timely file a
Form D with respect to the Securities as required under Regulation D and to provide a copy thereof to each Purchaser who requests a copy in writing promptly after such filing. The Company shall take such action as the Company shall
reasonably determine is necessary in order to qualify the Securities for sale to the Purchasers at the Closing pursuant to this Agreement under applicable securities or “Blue Sky” laws of the states of the United States (or to obtain an
exemption from such qualification), which, subject to the accuracy of the Company’s and the Purchaser’s representations and warranties set forth herein, shall consist of the submission of all filings and reports relating to the offer and
sale of the Securities pursuant to Rule 506 of Regulation D required under applicable securities or “Blue Sky” laws of the states of the United States following the Closing Date, and shall provide evidence of any such action so taken to
the Purchasers who request in writing such evidence. 
 4.6         No
Integration. Except for the Prior Financings, the Company shall not, and shall use its commercially reasonable efforts to ensure that the Affiliates of the Company shall not, sell, offer for sale or solicit offers to buy or otherwise negotiate
in respect of any security (as defined in Section 2 of the Securities Act) that will be integrated with the offer or sale of the Securities in a manner that would require the registration under the Securities Act of the sale of the Securities
to the Purchasers, or that will be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any Trading Market such that it would require shareholder approval prior to the closing of such other transaction
unless shareholder approval is obtained before the closing of such subsequent transaction. 

4.7        Securities Laws Disclosure; Publicity. By 9:00 a.m., New York City time,
on the Trading Day immediately following the execution of this Agreement, the Company shall issue a press release (the “Press Release”) disclosing all material terms of the transactions contemplated hereby. Within the time
required by the Exchange Act, the Company will file a Current Report on Form 8-K with the Commission describing the terms of the Transaction Documents (and including as exhibits to such Current Report on Form 8-K the material Transaction Documents
(including, without limitation, this Agreement and the Registration Rights Agreement)). Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser or an Affiliate of any Purchaser, or include the name of

  
 20. 

 
any Purchaser or an Affiliate of any Purchaser in any press release or filing with the Commission (other than the Registration Statement) or any regulatory agency or Trading Market, without the
prior written consent of such Purchaser, except (i) as required by federal securities law in connection with (A) any registration statement contemplated by the Registration Rights Agreement and (B) the filing of final Transaction
Documents (including signature pages thereto) with the Commission or (ii) to the extent such disclosure is required by law, request of the Staff of the Commission or Trading Market regulations, in which case the Company shall provide the
Purchasers with prior written notice of such disclosure permitted under this subclause (ii). From and after the issuance of the Press Release, no Purchaser shall be in possession of any material, non-public information received from the Company or
any of its respective officers, directors, employees or agents, that is not disclosed in the Press Release unless a Purchaser shall have executed a written agreement regarding the confidentiality and use of such information. Each Purchaser,
severally and not jointly with the other Purchasers, covenants that until such time as the transactions contemplated by this Agreement are publicly disclosed by the Company as described in this Section 4.7, such Purchaser will maintain the
confidentiality of all disclosures made to it in connection with such transactions (including the existence and terms of such transactions). 

4.8        Non-Public Information. Except with respect to the material terms and
conditions of the transactions contemplated by the Transaction Documents, the Company shall not and shall cause each of its officers, directors, employees and agents, not to, provide any Purchaser with any information the Company believes is
material, non-public information regarding the Company from and after the filing of the Press Release without the express written consent of such Purchaser, unless prior thereto such Purchaser shall have executed a written agreement regarding the
confidentiality and use of such information. 
 4.9        
Indemnification. 
   (a)         Indemnification of the
Purchasers. In addition to the indemnity provided in the Registration Rights Agreement, subject to this Section 4.9, the Company will indemnify and hold each Purchaser and its directors, officers, shareholders, members, partners, employees
and agents (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a lack of such title or any other title), each Person who controls such Purchaser (within the meaning of Section 15 of the
Securities Act and Section 20 of the Exchange Act), and the directors, officers, shareholders, agents, members, partners or employees (and any other Persons with a functionally equivalent role of a Person holding such titles notwithstanding a
lack of such title or any other title) of such controlling Person (each, a “Purchaser Party”) harmless from any and all losses, liabilities, obligations, claims, contingencies, damages, costs and expenses, including all
judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of investigation that any such Purchaser Party may suffer or incur, as a result of or relating to third party claims against such Purchaser relating to
any breach of any of the representations, warranties, covenants or agreements made by the Company in this Agreement or in the other Transaction Documents, provided that such a claim for indemnification relating to any breach of any of the
representations or warranties made by the Company in this Agreement is made within one (1) year from the Closing. The Company will not be liable to any Purchaser Party under this Agreement to the extent, but only to the extent that a loss,
claim, damage or liability is attributable to any Purchaser Party’s breach of any of the representations, warranties, covenants or agreements made by such Purchaser Party in this Agreement or in the other Transaction Documents. 

  (b)         Conduct of Indemnification Proceedings. Promptly
after receipt by any Person (the “Indemnified Person”) of notice of any demand, claim or circumstances which would or might give rise to a claim or the commencement of any action, proceeding or investigation in respect of
which indemnity may be sought pursuant to Section 4.9(a), such Indemnified Person shall promptly notify the Company in writing and the Company shall have the right to assume the defense thereof, including the

  
 21. 

 
employment of counsel reasonably satisfactory to such Indemnified Person and the assumption of the payment of all fees and expenses; provided, however, that the failure of any Indemnified
Person so to notify the Company shall not relieve the Company of its obligations hereunder except to the extent that the Company is actually and materially prejudiced by such failure to notify. In any such proceeding, any Indemnified Person shall
have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the expense of such Indemnified Person unless: (i) the Company and the Indemnified Person shall have mutually agreed to the retention of such
counsel; (ii) the Company shall have failed promptly to assume the defense of such proceeding and to employ counsel reasonably satisfactory to such Indemnified Person in such proceeding; or (iii) in the reasonable judgment of counsel to
such Indemnified Person and counsel to the Company, representation of both parties by the same counsel would be inappropriate due to actual or potential differing interests between them, in which case the Company shall be responsible for the
reasonable fees and expenses of no more than one such separate counsel. The Company shall not be liable for any settlement of any proceeding effected without its written consent, which consent shall not be unreasonably withheld, delayed or
conditioned. Without the prior written consent of the Indemnified Person, which consent shall not be unreasonably withheld, delayed or conditioned, the Company shall not effect any settlement of any pending or threatened proceeding in respect of
which any Indemnified Person is a party, unless such settlement includes an unconditional release of such Indemnified Person from all liability arising out of such Proceeding. 

4.10         Listing of Securities. In the time and manner required by the
Principal Trading Market, the Company shall prepare and file with such Trading Market any additional shares listing application that may be required by such Trading Market covering all of the Shares and shall use its commercially reasonable efforts
to take all steps necessary to maintain, so long as any other shares of Common Stock shall be so listed, such listing. 

4.11         Use of Proceeds. The Company intends to use the net proceeds from
the sale of the Securities hereunder for working capital and general corporate purposes, which includes, without limitation, research and development. 

4.12         Dispositions and Confidentiality After The Date Hereof. Each
Purchaser shall not, and shall cause its Trading Affiliates not to, prior to the effectiveness of the Registration Statement: (a) sell, offer to sell, solicit offers to buy, dispose of, loan, pledge or grant any right with respect to
(collectively, a “Disposition”) the Securities; or (b) engage in any hedging or other transaction which is designed or could reasonably be expected to lead to or result in a Disposition of the Securities by such
Purchaser or a Trading Affiliate, except, in each case, for Dispositions pursuant to an available exemption from, or in a transaction not subject to, the registration requirements of the Securities Act, and in compliance with any applicable state
and federal securities laws. In addition, the Purchaser agrees that for so long as it owns any Common Stock, it will not enter into any Short Sale of Shares executed at a time when the Purchaser has no equivalent offsetting long position in the
Common Stock. For purposes of determining whether the Purchaser has an equivalent offsetting long position in the Common Stock, shares that the Purchaser is entitled to receive within sixty (60) days (whether pursuant to contract or upon
conversion or exercise of convertible securities) will be included as if held long by the Purchaser. Such Purchaser covenants that neither it nor any Person acting on its behalf or pursuant to any understanding with it will engage in any
transactions in the Company’s securities (including, without limitation, any Short Sales involving the Company’s securities) during the period from the date hereof until the earlier of such time as (i) the transactions contemplated by
this Agreement are first publicly announced as described in Section 4.7 or (ii) this Agreement is terminated in full pursuant to Section 6.17. Notwithstanding the foregoing, in the case of a Purchaser that is a multi-managed
investment vehicle whereby separate portfolio managers manage separate portions of such Purchaser’s assets and the portfolio managers have no direct knowledge of the investment decisions made by the portfolio managers managing other portions of
such Purchaser’s assets, the representation set forth above shall apply only with respect to the portion of assets managed by 

  
 22. 

 
the portfolio manager that have knowledge about the financing transaction contemplated by this Agreement. Each Purchaser understands and acknowledges, severally and not jointly with any other
Purchaser, that the Commission currently takes the position that covering a short position established prior to effectiveness of a resale registration statement with shares included in such registration statement would be a violation of
Section 5 of the Securities Act, as set forth in Division of Corporation Financing Compliance and Disclosure Interpretation 239.10 regarding short selling. 

ARTICLE 5 
 CONDITIONS
PRECEDENT TO CLOSING 
 5.1        Conditions Precedent to the Obligations of
the Purchasers to Purchase Securities at the Closing. The obligation of each Purchaser listed on Annex A hereto to acquire Securities at the Closing is subject to the fulfillment to such Purchaser’s satisfaction, on or prior to the
Closing Date, of each of the following conditions, any of which may be waived by such Purchaser (as to itself only): 

  (a)        Representations and Warranties. The representations and
warranties of the Company contained herein shall be true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and warranties shall be true and
correct in all respects) as of the date when made and as of the Closing Date, as though made on and as of such date, except for such representations and warranties that speak as of a different specified date. 

  (b)        Performance. The Company shall have performed, satisfied
and complied in all material respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing. 

  (c)        No Injunction. No statute, rule, regulation, executive
order, decree, ruling or injunction shall have been enacted, entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction
Documents. 
   (d)        Consents. The Company shall have
obtained in a timely fashion any and all consents, permits, approvals, registrations and waivers necessary for consummation of the purchase and sale of the Securities at the Closing (including all Required Approvals, except for those set forth in
clauses (i), (ii), (iii) and (v) of Section 3.1(e), which may be obtained after the Closing), all of which shall be and remain so long as necessary in full force and effect. 

  (e)        No Suspensions of Trading in Common Stock. The Common
Stock shall not have been suspended, as of the Closing Date, by the Commission. 

  (f)        Company Deliverables. The Company shall have delivered
the Company Deliverables in accordance with Section 2.2(a). 

  (g)        Termination. This Agreement shall not have been
terminated as to such Purchaser in accordance with Section 6.17 herein. 

  (h)        Minimum and Maximum Raise. The Company shall have raised
gross proceeds pursuant to the issuance and sale of Shares under this Agreement of (i) at least three million dollars ($3,000,000), and (ii) no more than six million nine hundred thousand dollars ($6,900,000), subject to increase to no
more than seven million eight hundred thousand dollars ($7,800,000) upon the exercise of the Placement Agent’s over-allotment option. 

  
 23. 

 5.2        Conditions Precedent to the
Obligations of the Company to sell Securities at the Closing. The Company’s obligation to sell and issue the Securities to each Purchaser listed on Annex A hereto at the Closing is subject to the fulfillment to the satisfaction of
the Company on or prior to the Closing Date of the following conditions, any of which may be waived by the Company: 

  (a)        Representations and Warranties. The representations and
warranties made by such Purchaser in Section 3.2 hereof shall be true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and warranties
shall be true and correct in all respects) as of the date when made, and as of the Closing Date as though made on and as of such date, except for representations and warranties that speak as of a different specified date. 

  (b)        Performance. Such Purchaser shall have performed,
satisfied and complied in all material respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by such Purchaser at or prior to the Closing Date. 

  (c)        No Injunction. No statute, rule, regulation, executive
order, decree, ruling or injunction shall have been enacted, entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction
Documents. 
   (d)        Purchaser Deliverables. Such Purchaser
shall have delivered its Purchaser Deliverables in accordance with Section 2.2(b). 

  (e)        Termination. This Agreement shall not have been
terminated as to such Purchaser in accordance with Section 6.17 herein. 
 ARTICLE 6 

MISCELLANEOUS 

6.1         Fees and Expenses. Except as expressly set forth in the Transaction
Documents to the contrary, the Company and the Purchasers shall each pay the fees and expenses of their respective advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party in connection with the
negotiation, preparation, execution, delivery and performance of this Agreement. The Company shall pay all Transfer Agent fees, stamp taxes and other taxes and duties levied in connection with the sale and issuance of the Securities to the
Purchasers. 
 6.2         Entire Agreement. The Transaction Documents,
together with the exhibits and schedules thereto, contain the entire understanding of the parties with respect to the subject matter thereof and supersede all prior agreements, understandings, discussions and representations, oral or written, with
respect to such matters, which the parties acknowledge have been merged into such documents, exhibits and schedules. At or after the Closing, and without further consideration, the Company and the Purchasers will execute and deliver to the other
such further documents as may be reasonably requested in order to give practical effect to the intention of the parties under the Transaction Documents. 

  
 24. 

 6.3         Notices. Any and all
notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is
delivered via facsimile (provided the sender receives a machine-generated confirmation of successful transmission) at the facsimile number specified in this Section prior to 5:00 p.m., New York City time, on a Trading Day, (b) the next Trading
Day after the date of transmission, if such notice or communication is delivered via facsimile (provided the sender receives a machine-generated confirmation of successful transmission) at the facsimile number specified in this Section on a day that
is not a Trading Day or later than 5:00 p.m., New York City time, on any Trading Day, (c) the Trading Day following the date of mailing, if sent by U.S. nationally recognized overnight courier service with next day delivery specified, or
(d) upon actual receipt by the party to whom such notice is required to be given. The address for such notices and communications shall be as follows: 
  

			
	 If to the Company:
	  	 Ignyta, Inc.

		  	 11095 Flintkote Avenue, Suite D

		  	 San Diego, California 92121

		  	 Telephone No.:   (858) 255-5960

		  	 Facsimile No.:   (858) 255-5959

		  	 Attention:   Chief Executive Officer

		
	 With a copy to:
	  	 Morrison & Foerster LLP

		  	 12531 High Bluff Drive, Suite 100

		  	 San Diego, California 92130

		  	 Telephone No.:   (858) 720-5100

		  	 Facsimile No.:   (650) 720-5125

		  	 Attention:   Jay de Groot

		
	 If to a Purchaser:
	  	 To the address set forth under such Purchaser’s name on its signature page hereof;

 or such other address as may be designated in writing hereafter, in the same manner, by such Person. 

6.4         Amendments; Waivers; No Additional Consideration. No provision of
this Agreement may be waived or amended except in a written instrument signed, in the case of an amendment, by the Company and the Purchasers holding or having the right to acquire at least a majority of the Shares to be purchased at the Closing or
then outstanding or, in the case of a waiver, by the party against whom enforcement of any such waiver is sought. No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing
waiver in the future or a waiver of any subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right hereunder in any manner impair the exercise of any
such right. No consideration shall be offered or paid to any Purchaser to amend or consent to a waiver or modification of any provision of any Transaction Document unless the same consideration is also offered to all Purchasers who then hold
Securities. 
 6.5         Construction. The headings herein are for
convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual
intent, and no rules of strict construction will be applied against any party. This Agreement shall be construed as if drafted jointly by the parties, and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of
the authorship of any provisions of this Agreement or any of the Transaction Documents. 

  
 25. 

 6.6         Successors and
Assigns. The provisions of this Agreement shall inure to the benefit of and be binding upon the parties and their successors and permitted assigns. This Agreement, or any rights or obligations hereunder, may not be assigned by the Company
without the prior written consent of the Purchasers (other than by merger or consolidation or to an entity which acquires the Company, including by way of acquiring all or substantially all of the Company’s assets). Any Purchaser may assign its
rights hereunder in whole or in part to any Person to whom such Purchaser assigns or transfers any Securities in compliance with the Transaction Documents and applicable law, provided such transferee shall agree in writing to be bound, with respect
to the transferred Securities, by the terms and conditions of this Agreement that apply to the “Purchasers”. 

6.7         No Third-Party Beneficiaries. This Agreement is intended for the
benefit of the parties hereto and their respective successors and permitted assigns and is not for the benefit of, nor may any provision hereof be enforced by, any other Person. 

6.8         Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of this Agreement shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each party agrees that all
Proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement and any other Transaction Documents (whether brought against a party hereto or its respective Affiliates, employees or agents)
shall be commenced exclusively in the New York Courts. Each party hereto hereby irrevocably submits to the exclusive jurisdiction of the New York Courts for the adjudication of any dispute hereunder or in connection herewith or with any transaction
contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any Proceeding, any claim that it is not personally subject to the
jurisdiction of any such New York Court, or that such Proceeding has been commenced in an improper or inconvenient forum. Each party hereto hereby irrevocably waives personal service of process and consents to process being served in any such
Proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. EACH PARTY HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT
PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

6.9         Survival. The representations and warranties contained herein shall
survive the Closing and the delivery of the Securities for a period of one (1) year from the Closing Date. The agreements and covenants contained herein shall survive for the applicable statute of limitations. 

6.10       Execution. This Agreement may be executed in two or more counterparts,
all of which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that the parties need not sign the same
counterpart. In the event that any signature is delivered by facsimile transmission, or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or on
whose behalf such signature is executed) with the same force and effect as if such facsimile or “.pdf” signature page were an original thereof. 

6.11       Severability. If any provision of this Agreement is held to be invalid or
unenforceable in any respect, the validity and enforceability of the remaining terms and provisions of this Agreement shall not in any way be affected or impaired thereby and the parties will attempt to agree upon a valid and enforceable provision
that is a reasonable substitute therefor and achieves that same or substantially the same effect or result, and upon so agreeing, shall incorporate such substitute provision in this Agreement. 

  
 26. 

 6.12     Replacement of Securities. If any certificate
or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate
or instrument, but only upon receipt of evidence reasonably satisfactory to the Company and the Transfer Agent of such loss, theft or destruction and the execution by the holder thereof of a customary lost certificate affidavit of that fact and an
agreement to indemnify and hold harmless the Company and the Transfer Agent for any losses in connection therewith or, if required by the Transfer Agent, a bond in such form and amount as is required by the Transfer Agent. The applicants for a new
certificate or instrument under such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement Securities. If a replacement certificate or instrument evidencing any Securities is requested due to
a mutilation thereof, the Company may require delivery of such mutilated certificate or instrument as a condition precedent to any issuance of a replacement. 

6.13     Remedies. In addition to being entitled to exercise all rights provided herein or granted
by law, including recovery of damages, each of the Purchasers and the Company will be entitled to specific performance under the Transaction Documents. The parties agree that monetary damages may not be adequate compensation for any loss incurred by
reason of any breach of obligations described in the foregoing sentence and hereby agree to waive in any action for specific performance of any such obligation (other than in connection with any action for a temporary restraining order) the defense
that a remedy at law would be adequate. 
 6.14     Payment Set Aside. To the extent that the
Company makes a payment or payments to any Purchaser pursuant to any Transaction Document or a Purchaser enforces or exercises its rights thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof
are subsequently invalidated, declared to be fraudulent or preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company, a trustee, receiver or any other Person under any law
(including, without limitation, any bankruptcy law, state or federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and
continued in full force and effect as if such payment had not been made or such enforcement or setoff had not occurred. 

6.15     Adjustments in Share Numbers and Prices. In the event of any stock split, subdivision,
dividend or distribution payable in shares of Common Stock (or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly shares of Common Stock), combination or other similar recapitalization or
event occurring after the date hereof, each reference in any Transaction Document to a number of shares or a price per share shall be deemed to be amended to appropriately account for such event. 

6.16     Independent Nature of the Purchasers’ Obligations and Rights. The obligations of each
Purchaser under any Transaction Document are several and not joint with the obligations of any other Purchaser, and no Purchaser shall be responsible in any way for the performance of the obligations of any other Purchaser under any Transaction
Document. The decision of each Purchaser to purchase Securities pursuant to the Transaction Documents has been made by such Purchaser independently of any other Purchaser and independently of any information, materials, statements or opinions as to
the business, affairs, operations, assets, properties, liabilities, results of operations, condition (financial or otherwise) or prospects of the Company which may have been made or given by any other Purchaser or by any agent or employee of any
other Purchaser, and no Purchaser and any of its agents or employees shall have any liability to any other Purchaser (or any other Person) relating to or arising from any such 

  
 27. 

 
information, materials, statement or opinions. Nothing contained herein or in any other Transaction Document, and no action taken by any Purchaser pursuant hereto or thereto, shall be deemed to
constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions
contemplated by the Transaction Documents. Each Purchaser acknowledges that no other Purchaser has acted as agent for such Purchaser in connection with making its investment hereunder and that no Purchaser will be acting as agent of such Purchaser
in connection with monitoring its investment in the Securities or enforcing its rights under the Transaction Documents. Each Purchaser shall be entitled to independently protect and enforce its rights, including without limitation the rights arising
out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding for such purpose. The Company acknowledges that each of the Purchasers has
been provided with the same Transaction Documents for the purpose of closing a transaction with multiple Purchasers and not because it was required or requested to do so by any Purchaser. The Company’s obligations to each Purchaser under this
Agreement and the other Transaction Documents are identical to its obligations to each other Purchaser other than such differences resulting solely from the number of Securities purchased by such Purchaser. 

6.17     Termination. This Agreement may be terminated and the sale and purchase of the Shares
abandoned at any time prior to the Closing by either the Company or any Purchaser listed on Annex A hereto (with respect to itself only), upon written notice to the other, if the Closing has not been consummated on or prior to 5:00 p.m., New
York City time, on the Outside Date; provided, however, that the right to terminate this Agreement under this Section 6.17 shall not be available to any Person whose failure to comply with its obligations under this Agreement has been
the cause of or resulted in the failure of the Closing to occur on or before such time. Nothing in this Section 6.17 shall be deemed to release any party from any liability for any breach by such party of the terms and provisions of this
Agreement or the other Transaction Documents or to impair the right of any party to compel specific performance by any other party of its obligations under this Agreement or the other Transaction Documents. In the event of a termination pursuant to
this Section, the Company shall promptly notify all non-terminating Purchasers. Upon a termination in accordance with this Section, the Company and the terminating Purchaser(s) shall not have any further obligation or liability (including arising
from such termination) to the other, and no Purchaser will have any liability to any other Purchaser under the Transaction Documents as a result therefrom. 

6.18     Waiver of Conflicts. Each Purchaser acknowledges that: (a) it has read this
Agreement; (b) it has been represented in the preparation, negotiation and execution of this Agreement by legal counsel of its own choice or has voluntarily declined to seek such counsel; and (c) it understands the terms and consequences
of this Agreement and is fully aware of the legal and binding effect of this Agreement. Each Purchaser understands that the Company has been represented in the preparation, negotiation and execution of this Agreement by Morrison & Foerster
LLP, Company Counsel, and that Morrison & Foerster LLP has not represented any Purchaser or any stockholder, director or employee of the Company in the preparation, negotiation and execution of this Agreement. Each Purchaser acknowledges
that Morrison & Foerster LLP may have in the past represented and may now or may in the future represent one or more Purchasers or their Affiliates in matters unrelated to the transactions contemplated by this Agreement, including the
representation of such Purchasers or their Affiliates in matters of a nature similar to those contemplated by this Agreement. The Company and each Purchaser hereby acknowledge that they have has had an opportunity to ask for and have obtained
information relevant to such representation, including disclosure of the reasonably foreseeable adverse consequences of such representation, and hereby waives any conflict arising out of such representation with respect to the matters contemplated
by this Agreement. 

  
 28. 

 IN WITNESS WHEREOF, the parties hereto have caused this Securities
Purchase Agreement to be duly executed by their respective authorized signatories as of the date first indicated above. 
  

							
		  	 IGNYTA, INC.
	 	
			
		  	 By:
	 	   /s/ Jonathan Lim

		  	 Name: Jonathan Lim
	 	
		  	 Title: President and Chief Executive Officer
	 	

 ANNEX A: Schedule of Purchasers 

EXHIBITS: 
  

			
	 A:      
	  	 Registration Rights Agreement

	 B:
	  	 Irrevocable Transfer Agent Instructions

	 C:
	  	 Form of Secretary’s Certificate

	 D:
	  	 Form of Compliance Certificate

 ANNEX A 

SCHEDULE OF PURCHASERS 
  

									
	 Purchaser
	  	Number of Shares
Purchased	 	  	Aggregate
Purchase Price
(Subscription
Amount)	 
	 NFS/FMTC Trad. IRA FBO Normand F. Smith
	  	 	10,000       	  	  	$	60,000	  
	 John S. and Linda M. McPhee, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 NFS/FMTC SEP IRA FBO William Miller
	  	 	5,000       	  	  	$	30,000	  
	 Rhoda Ann Miller Trust
	  	 	10,000       	  	  	$	60,000	  
	 Anthony Behette
	  	 	10,000       	  	  	$	60,000	  
	 David W. Inglish
	  	 	10,000       	  	  	$	60,000	  
	 Alan Hertz
	  	 	4,500       	  	  	$	27,000	  
	 Mehrdad Mark Mofid and Mora Zohdi Mofid Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Craig D. Fishman and Lisa E. Fishman, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Yaroslav Stakhiv
	  	 	4,000       	  	  	$	24,000	  
	 Robert Kaufman
	  	 	83,333       	  	  	$	499,998	  
	 Gary W. Carlisle
	  	 	4,000       	  	  	$	24,000	  
	 Patrick Raymond Sullivan
	  	 	10,000       	  	  	$	60,000	  
	 NFS/FMTC Rollover IRA FBO Gary Schulz
	  	 	5,000       	  	  	$	30,000	  
	 Choe Ramsay Family Trust
	  	 	10,000       	  	  	$	60,000	  
	 Mark Schordock
	  	 	3,000       	  	  	$	18,000	  
	 John and Rosemary E. Schneider, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Daniel N. Sauder and Elizabeth Sauder, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Edward Lopez
	  	 	4,500       	  	  	$	27,000	  
	 Jack Chitayat
	  	 	16,666       	  	  	$	99,996	  
	 James W. Flynn
	  	 	3,000       	  	  	$	18,000	  
	 John R. Bartos
	  	 	10,000       	  	  	$	60,000	  
	 NFS/FMTC Rollover IRA FBO Brian A. Anderson
	  	 	3,000       	  	  	$	18,000	  
	 Jason Fadeyi
	  	 	10,000       	  	  	$	60,000	  
	 Larry Gelbfish
	  	 	3,000       	  	  	$	18,000	  
	 Tanju and Tina Obut, Jt. WROS
	  	 	8,000       	  	  	$	48,000	  
	 Robert C. Towns
	  	 	3,000       	  	  	$	18,000	  
	 Nick Valk
	  	 	5,000       	  	  	$	30,000	  
	 Luigi Mancini
	  	 	3,000       	  	  	$	18,000	  
	 Scott L.Summers
	  	 	3,000       	  	  	$	18,000	  
	 NFS/FMTC IRA FBO Stanley Michael Rein
	  	 	3,000       	  	  	$	18,000	  
	 Jastco Mayfair Intl. Property, LLC
	  	 	10,000       	  	  	$	60,000	  
	 NFS/FMTC Trad. IRA FBO Steven Vuyovich
	  	 	7,000       	  	  	$	42,000	  
	 James Somers
	  	 	5,000       	  	  	$	30,000	  
	 Keith O. Newton
	  	 	4,167       	  	  	$	25,002	  
	 Todd G. Bari
	  	 	3,000       	  	  	$	18,000	  
	 Patrick T. Lee
	  	 	10,000       	  	  	$	60,000	  
	 Jarter L. Fang
	  	 	5,000       	  	  	$	30,000	  
	 John Maddux
	  	 	5,000       	  	  	$	30,000	  
	 Allen and Jolaine Cage, Jt. WROS
	  	 	5,000       	  	  	$	30,000	  
	 TSAI Family Trust
	  	 	5,000       	  	  	$	30,000	  
	 NFS/FMTC Simple IRA Robertson Electric Co; Inc. FBO Bruce Locker
	  	 	5,000       	  	  	$	30,000	  
	 Sunstone Partners, LLC
	  	 	9,000       	  	  	$	54,000	  
	 Sooner Ranch Investments, LP
	  	 	3,000       	  	  	$	18,000	  
	 NFS/FMTC Rollover IRA FBO Jim Brummer
	  	 	4,000       	  	  	$	24,000	  
	 Bobby Purcell
	  	 	3,000       	  	  	$	18,000	  
	 NFS/FMTC Trad. IRA FBO Robert Gordon
	  	 	4,000       	  	  	$	24,000	  
	 Roger Nesbitt
	  	 	5,000       	  	  	$	30,000	  

									
	 Purchaser
	  	Number of Shares
Purchased	 	  	Aggregate
Purchase Price
(Subscription
Amount)	 
	 NFS/FMTC Rollover IRA FBO Daniel Wickard
	  	 	4,000       	  	  	$	24,000	  
	 Lawrence Coolidge
	  	 	10,000       	  	  	$	60,000	  
	 Nancy Meyers Coolidge
	  	 	10,000       	  	  	$	60,000	  
	 NFS/FMTC Rollover IRA FBO Michael Accardi
	  	 	4,000       	  	  	$	24,000	  
	 NFS/FMTC SEP IRA FBO Terry Mace
	  	 	3,000       	  	  	$	18,000	  
	 NFS/FMTC Trad. IRA FBO Paul D. McKinney
	  	 	10,000       	  	  	$	60,000	  
	 Jack Guiragosian
	  	 	3,000       	  	  	$	18,000	  
	 Richard Johnson
	  	 	3,000       	  	  	$	18,000	  
	 NFS/FMTC Trad. IRA FBO Roger Nesbitt
	  	 	5,000       	  	  	$	30,000	  
	 Marvin Mermelstein
	  	 	3,000       	  	  	$	18,000	  
	 Madeleine Behette
	  	 	10,000       	  	  	$	60,000	  
	 George R. Martin
	  	 	4,000       	  	  	$	24,000	  
	 The Ginsburg Family Trust
	  	 	2,000       	  	  	$	12,000	  
	 Navin Singh
	  	 	10,000       	  	  	$	60,000	  
	 Terry Mace and Cindy Sue Mace, Jt. WROS
	  	 	13,000       	  	  	$	78,000	  
	 Lloyd and Deborah Schill JT WROS
	  	 	3,500       	  	  	$	21,000	  
	 Dr. Kevin Hsu
	  	 	5,000       	  	  	$	30,000	  
	 Tanvir Ali Master
	  	 	5,000       	  	  	$	30,000	  
	 Peter C. Beale
	  	 	3,500       	  	  	$	21,000	  
	 Reesman’s Excavating and Grading, Inc.
	  	 	10,000       	  	  	$	60,000	  
	 Jorge Morazzani
	  	 	3,000       	  	  	$	18,000	  
	 Michael Ebedes
	  	 	3,000       	  	  	$	18,000	  
	 Stuart Simpson
	  	 	3,000       	  	  	$	18,000	  
	 Howard K. Fuguet
	  	 	3,000       	  	  	$	18,000	  
	 Charles Dossett
	  	 	10,000       	  	  	$	60,000	  
	 Ellis R. Guilbeau
	  	 	3,000       	  	  	$	18,000	  
	 Jeffrey J. Stoen
	  	 	4,000       	  	  	$	24,000	  
	 East Hudson Enterprises, Inc.
	  	 	4,000       	  	  	$	24,000	  
	 NFS/FMTC Rollover IRA FBO Timothy W. Hansen
	  	 	8,333       	  	  	$	49,998	  
	 Thomas and Susan Mary Garrity, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Terry G. Han
	  	 	5,000       	  	  	$	30,000	  
	 Wing Real Estate, LLC
	  	 	10,000       	  	  	$	60,000	  
	 Albert B. Erwin, Jr.
	  	 	4,000       	  	  	$	24,000	  
	 Barry Frost
	  	 	3,000       	  	  	$	18,000	  
	 William Ristvedt
	  	 	3,000       	  	  	$	18,000	  
	 Thomas V. Gerardi
	  	 	6,666       	  	  	$	39,996	  
	 Gunther Well and Pump Services, LLC
	  	 	6,000       	  	  	$	36,000	  
	 Mario Dell’Aera
	  	 	4,000       	  	  	$	24,000	  
	 Gary L. Sturm
	  	 	10,000       	  	  	$	60,000	  
	 Dr. David Shively Rev. Dynastic with Preservation Trust
	  	 	8,300       	  	  	$	49,800	  
	 Roger J. Schwarz
	  	 	10,000       	  	  	$	60,000	  
	 Moe H. Leichter
	  	 	5,000       	  	  	$	30,000	  
	 Lowell Pearson
	  	 	3,000       	  	  	$	18,000	  
	 Russell Nowak
	  	 	9,000       	  	  	$	54,000	  
	 Rush M. Waite
	  	 	10,000       	  	  	$	60,000	  
	 Donald P. Sesterhenn
	  	 	4,000       	  	  	$	24,000	  
	 Michael Padgett
	  	 	4,000       	  	  	$	24,000	  
	 G. O’Connor Trust
	  	 	10,000       	  	  	$	60,000	  
	 David and Carolyn Schmitz, Jt. WROS
	  	 	4,000       	  	  	$	24,000	  
	 Jeffrey Miller
	  	 	4,000       	  	  	$	24,000	  
	 Pasquale V. and Maria Stiso, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Kevin Barry
	  	 	5,000       	  	  	$	30,000	  

									
	 Purchaser
	  	Number of Shares
Purchased	 	  	Aggregate
Purchase Price
(Subscription
Amount)	 
	 Ray Crespo
	  	 	10,000       	  	  	$	60,000	  
	 Tech Plan Inc.
	  	 	10,000       	  	  	$	60,000	  
	 Dr. David Shively
	  	 	8,300       	  	  	 	49,800	  
	 Brian Skillern
	  	 	4,300       	  	  	$	25,800	  
	 Max G. Johnson TTEE/Max Johnson Living Trust U/A 1/7/99
	  	 	10,000       	  	  	$	60,000	  
	 George E. Berkey
	  	 	3,000       	  	  	$	18,000	  
	 Douglas Brody
	  	 	3,000       	  	  	$	18,000	  
	 Salvatore Thomas and Jacqueline Butera JT. WROS
	  	 	3,000       	  	  	$	18,000	  
	 David B. O’Neill
	  	 	4,000       	  	  	$	24,000	  
	 Andrew Alltizer
	  	 	4,000       	  	  	$	24,000	  
	 Michael D. Langan
	  	 	3,000       	  	  	$	18,000	  
	 David C. Bukzin
	  	 	7,000       	  	  	$	42,000	  
	 Alon Kessler
	  	 	3,000       	  	  	$	18,000	  
	 Michael P. Giannelli
	  	 	10,000       	  	  	$	60,000	  
	 Tony Y. Maung
	  	 	10,000       	  	  	$	60,000	  
	 Tom Herburger
	  	 	6,000       	  	  	$	36,000	  
	 Julie Hess and Michael Hess, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 William Huff
	  	 	8,300       	  	  	$	49,800	  
	 Randy Perillo
	  	 	10,000       	  	  	$	60,000	  
	 Jules and Deborah G. DeVigne, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Michael Hafke
	  	 	10,000       	  	  	$	60,000	  
	 3MD Partnership, Ltd., Don B. Whaley
	  	 	4,100       	  	  	$	24,600	  
	 Wilson Chen
	  	 	5,000       	  	  	$	30,000	  
	 Michael Cullen
	  	 	7,000       	  	  	$	42,000	  
	 Robert Biederman
	  	 	4,000       	  	  	$	24,000	  
	 Tom Giftos
	  	 	3,000       	  	  	$	18,000	  
	 Stefan and Kerstin Kneis, Jt. WROS
	  	 	8,500       	  	  	$	51,000	  
	 James G. Reed
	  	 	8,333       	  	  	$	49,998	  
	 John E. Crisp
	  	 	10,000       	  	  	$	60,000	  
	 Thomas C. Tillotson
	  	 	3,000       	  	  	$	18,000	  
	 Kenneth Laviano
	  	 	3,000       	  	  	$	18,000	  
	 Ruby B. Lee
	  	 	15,000       	  	  	$	90,000	  
	 Karen Jean Gilmore and Raymond Gary Gilmore, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Earl Sauls
	  	 	4,000       	  	  	$	24,000	  
	 Jeffrey Bunker
	  	 	3,000       	  	  	$	18,000	  
	 Craig Child
	  	 	4,300       	  	  	$	25,800	  
	 Stanley O. Uptigrove
	  	 	3,500       	  	  	$	21,000	  
	 Stefan Nowina
	  	 	10,000       	  	  	$	60,000	  
	 Steven J. Vuyovich and Mary E. Vuyovich, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Eugene Chen and Jennifer Chen, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Jules DeVigne
	  	 	10,000       	  	  	$	60,000	  
	 Jonathan Gralnick
	  	 	3,000       	  	  	$	18,000	  
	 Keith Jackson
	  	 	4,000       	  	  	$	24,000	  
	 Harry Neff
	  	 	5,000       	  	  	$	30,000	  
	 Tony G. Puckett
	  	 	3,000       	  	  	$	18,000	  
	 Sharad and Chandrikda Patel, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 John Brad Carlin
	  	 	3,000       	  	  	$	18,000	  
	 PJS Inc.
	  	 	5,000       	  	  	$	30,000	  
	 Brett Ferenchak
	  	 	4,000       	  	  	$	24,000	  
	 Steve Kontos
	  	 	7,916       	  	  	$	47,496	  
	 Jan P. Miller
	  	 	4,000       	  	  	$	24,000	  
	 Michael Kontos
	  	 	7,916       	  	  	$	47,496	  

									
	 Purchaser
	  	Number of Shares
Purchased	 	  	Aggregate
Purchase Price
(Subscription
Amount)	 
	 John G. Kalyvas
	  	 	4,000       	  	  	$	 24,000	  
	 Dr. Larry Hauskins
	  	 	5,000       	  	  	$	30,000	  
	 William M. Kong and Joy S. Kong, Jt. WROS
	  	 	3,500       	  	  	$	21,000	  
	 Blue Ocean, LLC
	  	 	10,000       	  	  	$	60,000	  
	 DJDDT Properties, LLC
	  	 	10,000       	  	  	$	60,000	  
	 Paramount Biosciences
	  	 	10,000       	  	  	$	60,000	  
	 RAQ LLC
	  	 	10,000       	  	  	$	60,000	  
	 RNW LLC
	  	 	10,000       	  	  	$	60,000	  
	 Lindsay A. Rosenwald
	  	 	10,000       	  	  	$	60,000	  
	 Marguerite Behette-Hart
	  	 	10,000       	  	  	$	60,000	  
	 Joseph P. Slattery
	  	 	4,000       	  	  	$	24,000	  
	 James P. McCarthy
	  	 	10,000       	  	  	$	60,000	  
	 Timothy E. Pauling
	  	 	4,000       	  	  	$	24,000	  
	 Simon Muzio and Enas Muzio, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Glendenning Investment Group
	  	 	4,000       	  	  	$	24,000	  
	 Douglas Grant
	  	 	10,000       	  	  	$	60,000	  
	 Navy Bancorp, Inc.
	  	 	3,000       	  	  	$	18,000	  
	 Grant’s Engineering and Machine Company
	  	 	8,000       	  	  	$	48,000	  
	 Kevin Gabrik
	  	 	5,000       	  	  	$	30,000	  
	 Chary Corp.
	  	 	6,000       	  	  	$	36,000	  
	 Gregory Hurley
	  	 	10,000       	  	  	$	60,000	  
	 GST Exempt Trust Created Under Jacob Lomazow Rev. Trust
	  	 	5,000       	  	  	$	30,000	  
	 Duncan J. Milcetic
	  	 	4,000       	  	  	$	24,000	  
	 Steve and Patricia Wubker, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Norman Sunamoto
	  	 	10,000       	  	  	$	60,000	  
	 Tony L. Chang and Tinyee T. Chang Rev. Trust 2013 DTD 10/28/13
	  	 	10,000       	  	  	$	60,000	  
	 Carlo Alberici
	  	 	3,000       	  	  	$	18,000	  
	 Joseph M. Diangelo
	  	 	4,166       	  	  	$	24,996	  
	 John Charles Lewis and Susan Elizabeth Kenney, Jt. WROS
	  	 	3,000       	  	  	$	18,000	  
	 Daniel T. Tsai and Lilliam T. Tsai, Jt. WROS
	  	 	5,000       	  	  	$	30,000	  
	 Carol H. Price and Duane Mathiowetz, Jt. WROS
	  	 	10,000       	  	  	$	60,000	  
	 Grady S. Hurley
	  	 	3,000       	  	  	$	18,000	  
	 Duane H. Mathiowetz
	  	 	10,000       	  	  	$	60,000	  
	 Ann Robbins Trust
	  	 	4,000       	  	  	$	24,000	  
	 David Mark Goldhagen
	  	 	5,000       	  	  	$	30,000	  
	 Stanley B. Miles
	  	 	3,500       	  	  	$	21,000	  
	 David Jarrett
	  	 	5,000       	  	  	$	30,000	  
	 Timothy Moreau
	  	 	6,000       	  	  	$	36,000	  
	 Environeering, Inc.
	  	 	3,000       	  	  	$	18,000	  
	 Patrick C. Sargent
	  	 	10,000       	  	  	$	60,000	  
	 William L. Lurie and Rita M. Lurie, Jt. WROS
	  	 	5,000       	  	  	$	30,000	  
	 R.B. Wilchar
	  	 	5,000       	  	  	$	30,000	  
	 Michael A. Mullen
	  	 	3,000       	  	  	$	18,000	  
	 TOTAL
	  	 	1,270,096       	  	  	$	7,620,576	  

 EXHIBIT A 

REGISTRATION RIGHTS AGREEMENT 

 EXHIBIT B 

FORM OF IRREVOCABLE TRANSFER AGENT INSTRUCTIONS 

As of             , 2013 

Olde Monmouth Stock Transfer Co., Inc. 

Transfer Agent and Registrar 
 200
Memorial Parkway 
 Atlantic Highlands, NJ 07716 

Attn:                      

Ladies and Gentlemen: 

Reference is made to that certain Securities Purchase Agreement, dated as of
                        , 2013 (the “Agreement”), by and among Ignyta, Inc., a Nevada corporation
(the “Company”), and the purchasers named on the signature pages thereto (collectively, and including permitted transferees, the “Holders”), pursuant to which the Company is issuing to the Holders
shares (the “Shares”) of Common Stock of the Company, par value $0.00001 per share (the “Common Stock”). 

This letter shall serve as our irrevocable authorization and direction to you (provided that you are the transfer agent of the
Company at such time and the conditions set forth in this letter are satisfied), subject to any stop transfer instructions that we may issue to you from time to time, if any, to (i) issue, promptly following the date hereof, certificates
representing the Shares bearing the legend set forth herein below, in the names of the Holders and the number of Shares as set forth in the attachments delivered herewith, and to deliver such certificates within six (6) business days after the
date hereof to the address for each such Holder as set forth on such attachments delivered herewith, and (ii) issue certificates representing shares of Common Stock upon transfer or resale of the Shares, which certificates shall or shall not
bear the legend set forth herein below as described below. 
 You acknowledge and agree that so long as you have received
(a) written confirmation from the Company’s legal counsel that a registration statement covering resales of the Shares has been declared effective by the Securities and Exchange Commission (the “Commission”) under
the Securities Act of 1933, as amended (the “Securities Act”), a copy of such registration statement and any other documents reasonably requested by you from the applicable Holder (and provided that you have not received
written instruction from the Company or its legal counsel that such registration statement has been suspended or is no longer effective), (b) written confirmation from the Company’s legal counsel that the Shares are eligible for sale in
conformity with Rule 144 under the Securities Act (“Rule 144”) and customary documentation from a Holder and its broker with respect to a sale pursuant to Rule 144, or (c) written confirmation from the Company’s
legal counsel that the Shares are eligible for sale without the requirement that the Company be in compliance with the current public information requirements of Rule 144 and without other restriction in conformity with Rule 144, then, unless
otherwise required by law, within three (3) business days of your receipt of certificate of Common Stock and documentation required pursuant to clause (a) or (b) above, as applicable, or a request from a Holder for the issuance of an
unlegended certificate in the event that you have received the written confirmation set forth in clause (c) above, you shall issue the certificates representing the Shares registered in the names of the purchaser of such Shares or the Holder,
as the case may be, and such certificates shall not bear any legend restricting transfer of the Shares thereby and should not be subject to any stop-transfer restriction. 

 All certificates representing the Shares issued pursuant to the instruction set
forth in clause (i) of the second paragraph of this letter shall bear the following legend (and, solely to the extent instructed to you by the Company or its legal counsel, a customary “affiliates” legend), and, in the event that you
have not received the documentation required pursuant to clause (a), (b) or (c) of the immediately preceding paragraph, then the certificates representing any shares of Common Stock issued pursuant to the instruction set forth in clause
(ii) of the second paragraph of this letter shall bear the following legend: 
 THESE SECURITIES HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF (A) AN
EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OR (B) AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE
SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY. 
 Please be advised that
the Holders are relying upon this letter as an inducement to enter into the Agreement and, accordingly, each Holder is a third party beneficiary to these instructions. 

Please execute this letter in the space indicated to acknowledge your agreement to act in accordance with these instructions.

  

			
	 Very truly yours,

	
	 IGNYTA, INC.

	
	
By:                      
                                         
                                

		
	 Name:
	 	 Jonathan Lim

		
	 Title:
	 	 President and Chief Executive Officer

 Acknowledged and Agreed: 

OLDE MONMOUTH STOCK TRANSFER CO., INC. 
  

	
	
By:                      
                                         
                          

	
Name:                     
                                         
                     

	
Title:                     
                                         
                       

	
Date:                     
                                         
                       

 EXHIBIT C 

FORM OF SECRETARY’S CERTIFICATE 

Date:                     , 2013

 The undersigned hereby certifies that he is the duly elected, qualified and acting Secretary of Ignyta, Inc., a Nevada
corporation (the “Company”), and that as such he is authorized to execute and deliver this certificate in the name and on behalf of the Company and in connection with the Securities Purchase Agreement, dated as of
                    , 2013, by and among the Company and the Purchasers party thereto (the “Securities Purchase
Agreement”), and further certifies in his official capacity, in the name and on behalf of the Company, the items set forth below. Capitalized terms used but not otherwise defined herein shall have the meaning set forth in the Securities
Purchase Agreement. 
 1.         Attached hereto as Exhibit A is a true,
correct and complete copy of the resolutions duly adopted by the Board of Directors of the Company at a meeting of the Board of Directors held on, or by unanimous written consent dated, October 31, 2013. Such resolutions have not in any way
been amended, modified, revoked or rescinded, have been in full force and effect since their adoption to and including the date hereof and are now in full force and effect. 

2.         Attached hereto as Exhibit B is a true, correct and complete copy of
the Certificate of Incorporation of the Company, together with any and all amendments thereto currently in effect, and no action has been taken to further amend, modify or repeal such Certificate of Incorporation, the same being in full force and
effect in the attached form as of the date hereof. 
 3.         Attached hereto as
Exhibit C is a true, correct and complete copy of the Bylaws of the Company and any and all amendments thereto currently in effect, and no action has been taken to further amend, modify or repeal such Bylaws, the same being in full force and
effect in the attached form as of the date hereof. 
 4.         Each person listed
below has been duly elected or appointed to the position(s) indicated opposite his name and is duly authorized to sign the Securities Purchase Agreement and each of the Transaction Documents on behalf of the Company, and the signature appearing
opposite such person’s name below is such person’s genuine signature. 
  

					
	 Name
	  	 Position
	  	 Signature

			
	 Jonathan Lim
	  	 President, Chief Executive Officer
	  	  

			
	 Zachary Hornby
	  	 Chief Financial Officer, Vice
President, Corporate
Development, and Secretary
	  	  

 IN WITNESS
WHEREOF, the undersigned has executed this Secretary’s Certificate as of the date first written above. 
  

	
	  

Zachary Hornby

	 Secretary

 I, Jonathan Lim, President and Chief Executive Officer of the Company, hereby certify
that Zachary Hornby is the duly elected, qualified and acting Secretary of the Company and that the signature set forth above is his true signature. 
  

	
	  

Jonathan Lim

	 President, Chief Executive Officer

 EXHIBIT A 

RESOLUTIONS 

 EXHIBIT B 

CERTIFICATE OF INCORPORATION 

 EXHIBIT C 

BYLAWS 

 EXHIBIT D 

FORM OF COMPLIANCE CERTIFICATE 

Date:                     , 2013

 The undersigned President and Chief Executive Officer of Ignyta, Inc., a Nevada corporation (the
“Company”), pursuant to Section 2.2(a)(vi) of the Securities Purchase Agreement, dated as of
                    , 2013, by and among the Company and the Purchasers signatory thereto (the “Agreement”), hereby
certifies to such Purchasers as follows (capitalized terms used but not otherwise defined herein shall have the meaning set forth in the Agreement): 

1.         The representations and warranties of the Company contained in the
Agreement are true and correct in all material respects (except for those representations and warranties which are qualified as to materiality, in which case such representations and warranties are true and correct in all respects) as of the date
when made and as of the Closing Date, as though made on and as of such date, except for such representations and warranties that speak as of a different specified date. 

2.         The Company has performed, satisfied and complied in all material respects
with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing. 

 IN WITNESS WHEREOF, the
undersigned has executed this Compliance Certificate as of the date first written above. 
  

	
	  

Jonathan Lim

	 President and Chief Executive OfficerEX-4.1

 Exhibit 4.1 
  

 
  

DUKE REALTY LIMITED PARTNERSHIP 

ISSUER 
 TO 

THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. 

TRUSTEE 
 ELEVENTH
SUPPLEMENTAL INDENTURE 
 DATED AS OF DECEMBER 3, 2013 

$ 250,000,000 3.875% SENIOR NOTES DUE 2021 

SUPPLEMENT TO INDENTURE, 

DATED AS OF JULY 28, 2006, BETWEEN 

DUKE REALTY LIMITED PARTNERSHIP AND 

THE BANK OF NEW YORK MELLON TRUST COMPANY N.A. (AS SUCCESSOR TO 

J.P. MORGAN TRUST COMPANY, NATIONAL ASSOCIATION) 
  

 
  

 ELEVENTH SUPPLEMENTAL INDENTURE, dated as of December 3, 2013,
between DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited partnership (the “Issuer”), having its principal offices at 600 East 96th Street, Suite 100, Indianapolis, IN 46240 and THE
BANK OF NEW YORK MELLON TRUST COMPANY, N.A. (as successor to J.P. MORGAN TRUST COMPANY, National Association), a national banking association organized under the laws of the United States of America, as trustee (the “Trustee”), having its
Corporate Trust Office at 2 N. LaSalle Street, Suite 1020, Chicago, Illinois 60602. 
 RECITALS 

WHEREAS, the Issuer executed and delivered its Indenture (the “Original Indenture”), dated as of
July 28, 2006, to the Trustee to issue from time to time for its lawful purposes debt securities evidencing its unsecured indebtedness. 

WHEREAS, the Original Indenture provides that by means of a supplemental indenture, the Issuer may create one or more
series of its debt securities and establish the form and terms and conditions thereof. 
 WHEREAS, the Issuer intends
by this Eleventh Supplemental Indenture to (i) create a series of debt securities, in an initial aggregate principal amount of $250,000,000, entitled “Duke Realty Limited Partnership 3.875% Senior Notes due 2021” (the
“Notes”); and (ii) establish the form and the terms and conditions of such Notes. 
 WHEREAS, the
Board of Directors of Duke Realty Corporation, the general partner of the Issuer, acting through authority delegated to certain of its executive officers, has approved the creation of the Notes and the form, terms and conditions thereof. 

WHEREAS, the consent of Holders to the execution and delivery of this Eleventh Supplemental Indenture is not required,
and all other actions required to be taken under the Original Indenture with respect to this Eleventh Supplemental Indenture have been taken. 

NOW, THEREFORE IT IS AGREED: 

ARTICLE ONE 

Definitions, Creation, Form and Terms and Conditions of the Debt Securities 

SECTION 1.01. Definitions. Capitalized terms used in this Eleventh Supplemental Indenture and not otherwise defined
shall have the meanings ascribed to them in the Original Indenture. In addition, the following terms shall have the following meanings to be equally applicable to both the singular and the plural forms of the terms defined: 

“DTC” means The Depository Trust Company. 

“Global Note” means a single fully-registered global note in book-entry form, without coupons, substantially
in the form of Exhibit A attached hereto. 

  
 1 

 “Indenture” means the Original Indenture as supplemented by this
Eleventh Supplemental Indenture. 
 “Make-Whole Amount” means, in connection with any optional redemption
or accelerated payment of any Note, the excess, if any, of (i) the aggregate present value as of the date of such redemption or accelerated payment of each dollar of principal being redeemed or paid and the amount of interest (exclusive of
interest accrued to the date of redemption or accelerated payment) that would have been payable in respect of each such dollar if such redemption or accelerated payment had not been made, determined by discounting, on a semi-annual basis, such
principal and interest at the Reinvestment Rate (determined on the third Business Day preceding the date such notice of redemption is given or declaration of acceleration is made) from the respective dates on which such principal and interest would
have been payable if such redemption or accelerated payment had not been made, over (ii) the aggregate principal amount of the Notes being redeemed or paid. 

“Notes” means the Issuer’s 3.875% Senior Notes due February 15, 2021, a form of which is attached
hereto as Exhibit A. 
 “Redemption Price” means the sum of (i) the principal amount of the
Notes being redeemed and (ii) the Make-Whole Amount, if any, with respect to such Notes, in either case plus accrued and unpaid interest thereon to, but excluding, the Redemption Date; provided, however, that if the Redemption Date is any time
on or after December 15, 2020, the Redemption Price shall mean the principal amount of the Notes being redeemed plus accrued and unpaid interest thereon to, but excluding, the Redemption Date. 

“Reinvestment Rate” means 0.300% plus the arithmetic mean of the yields under the respective heading
“Week Ending” published in the most recent Statistical Release under the caption “Treasury Constant Maturities” for the maturity (rounded to the nearest month) corresponding to the remaining life to maturity, as of the payment
date of the principal being redeemed or paid. If no maturity exactly corresponds to such maturity, yields for the two published maturities most closely corresponding to such maturity shall be calculated pursuant to the immediately preceding sentence
and the Reinvestment Rate shall be interpolated or extrapolated from such yields on a straight-line basis, rounding in each of such relevant periods to the nearest month. For the purposes of calculating the Reinvestment Rate, the most recent
Statistical Release published prior to the date of determination of the Make-Whole Amount shall be used. 

“Statistical Release” means the statistical release designated “H.15” or any successor publication
which is published weekly by the Federal Reserve System and which establishes yields on actively traded United States government securities adjusted to constant maturities, or, if such statistical release is not published at the time of any
determination under the Indenture, then such other reasonably comparable index which shall be designated by the Issuer. 

SECTION 1.02. Creation of the Debt Securities. In accordance with Section 301 of the Original Indenture, the
Issuer hereby creates the Notes as a separate series of its debt securities issued pursuant to the Indenture. The Notes shall be issued in an aggregate principal amount initially limited to $250,000,000. 

  
 2 

 The Issuer may issue, in addition to the Notes originally issued on the date
hereof, additional Notes. The Notes originally issued on the date hereof and any additional Notes originally issued subsequent to the date hereof shall be a single series for all purposes under the Original Indenture. 

SECTION 1.03. Form of the Debt Securities. The Notes will be represented by a single fully-registered global note in
book-entry form, without coupons, registered in the name of the nominee of DTC. The Notes shall be in the form of Exhibit A attached hereto. So long as DTC, or its nominee, is the registered owner of a Global Note, DTC or its nominee, as the
case may be, will be considered the sole owner or holder of the notes represented by such Global Note for all purposes under the Indenture. Ownership of beneficial interests in the Global Note will be shown on, and transfers thereof will be effected
only through, records maintained by DTC (with respect to beneficial interests of participants) or by participants or persons that hold interests through participants (with respect to beneficial interests of beneficial owners). 

SECTION 1.04. Terms and Conditions of the Debt Securities. The Notes shall be governed by all the terms and conditions
of the Original Indenture, as supplemented and modified by this Eleventh Supplemental Indenture, and in particular, the following provisions shall be terms of the Notes: 

(a) Optional Redemption. The Issuer may redeem the Notes at any time at the option of the Issuer, in whole or from time
to time in part, at a redemption price equal to the Redemption Price. 
 If notice has been given as provided in the
Original Indenture and funds for the redemption of any Notes called for redemption shall have been made available on the Redemption Date referred to in such notice, such Notes will cease to bear interest on the date fixed for such redemption
specified in such notice and the only right of the Holders of the Notes will be to receive payment of the Redemption Price. 

Notice of any optional redemption of any Notes will be given to Holders at their addresses, as shown in the Security Register,
not more than 60 nor less than 30 days prior to the date fixed for redemption. The notice of redemption will specify, among other items, the Redemption Price and the principal amount of the Notes held by such Holder to be redeemed. 

If less than all the Notes are to be redeemed at the option of the Issuer, the Issuer will notify the Trustee at least 45 days
prior to giving notice of redemption (or such shorter period as is satisfactory to the Trustee) of the aggregate principal amount of Notes to be redeemed and their Redemption Date. The Trustee shall select, in such manner as it shall deem fair and
appropriate and in accordance with applicable depositary procedures, Notes to be redeemed in whole or in part. 
 (b)
Payment of Principal and Interest. Principal and interest payments on interests represented by a Global Note will be made to DTC or its nominee, as the case may be, as the registered owner of such Global Note. All payments of principal and
interest in respect of the Notes will be made by the Issuer in immediately available funds. 

  
 3 

 (c) Applicability of Defeasance or Covenant Defeasance. The provisions of
Article 14 of the Original Indenture shall apply to the Notes. 
 (d) Definition of Total Unencumbered Assets. For
purposes of the covenant entitled “Maintenance of Total Unencumbered Assets” in Section 1005 of the Original Indenture, the term “Total Unencumbered Assets” shall be defined, solely with respect to the Notes, as follows:

 “Total Unencumbered Assets” means the sum of (i) those Undepreciated Real Estate Assets not subject to an
encumbrance and (ii) all other assets of the Issuer and its Subsidiaries not subject to an encumbrance determined in accordance with GAAP (but excluding intangibles and accounts receivable); provided, however, that all investments by the Issuer
and its Subsidiaries in unconsolidated joint ventures, unconsolidated limited partnerships, unconsolidated limited liability companies and other unconsolidated entities shall be excluded from the calculation of Total Unencumbered Assets to the
extent that such investments would have otherwise been included. 
 (e) Cross-Acceleration. For purposes of the Event
of Default provided for in Section 501(5) of the Original Indenture, all references to the amount of $5,000,000 shall be increased to $50,000,000; provided, however, that for so long as any of the securities issued pursuant to any supplemental
indenture to the Original Indenture that preceded this Eleventh Supplemental Indenture are outstanding and provide for this same Event of Default but for a lower amount of such recourse debt, the reference to $50,000,000 in this paragraph is
replaced by such lower amount. 
 ARTICLE TWO 

Trustee 

SECTION 2.01. Trustee. The Trustee shall not be responsible in any manner whatsoever for or in respect of the validity
or sufficiency of this Eleventh Supplemental Indenture or the due execution thereof by the Issuer. The recitals of fact contained herein shall be taken as the statements solely of the Issuer, and the Trustee assumes no responsibility for the
correctness thereof. 
 ARTICLE THREE 

Miscellaneous Provisions 

SECTION 3.01. Ratification of Original Indenture. This Eleventh Supplemental Indenture is executed and shall be
construed as an indenture supplemental to the Original Indenture, and as supplemented and modified hereby, the Original Indenture is in all respects ratified and confirmed, and the Original Indenture and this Eleventh Supplemental Indenture shall be
read, taken and construed as one and the same instrument. Notwithstanding anything herein to the contrary, to the extent any provision of this Eleventh Supplemental Indenture is inconsistent with any provision of the Original Indenture, the terms of
this Eleventh Supplemental Indenture shall govern and apply to the Notes. 

  
 4 

 SECTION 3.02. Effect of Headings. The Article and Section headings herein
are for convenience only and shall not affect the construction hereof. 
 SECTION 3.03. Successors and Assigns. All
covenants and agreements in this Eleventh Supplemental Indenture by the Issuer shall bind its successors and assigns, whether so expressed or not. 

SECTION 3.04. Separability Clause. In case any one or more of the provisions contained in this Eleventh Supplemental
Indenture shall for any reason be held to be invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

SECTION 3.05. Governing Law. This Eleventh Supplemental Indenture shall be governed by and construed in accordance with
the laws of the State of New York. This Eleventh Supplemental Indenture is subject to the provisions of the Trust Indenture Act of 1939, as amended, that are required to be part of this Eleventh Supplemental Indenture and shall, to the extent
applicable, be governed by such provisions. 
 SECTION 3.06. Counterparts. This Eleventh Supplemental Indenture may
be executed in any number of counterparts, and each of such counterparts shall for all purposes be deemed to be an original, but all such counterparts shall together constitute one and the same instrument. 

  
 5 

 IN WITNESS WHEREOF, the parties hereto have caused this Eleventh
Supplemental Indenture to be duly executed, and their respective corporate seals to be hereunto affixed and attested, all as of the date first above written. 

 

							
	DUKE REALTY LIMITED PARTNERSHIP
		 	as Issuer
		
	By:	 	DUKE REALTY CORPORATION,
		 	its General Partner
			
		 	By:	 	 /s/ Mark A. Denien

		 		 	Name:	 	Mark A. Denien
		 		 	Title:	 	Executive Vice President and Chief Financial Officer

  

			
	Attest:
	
	 /s/ Ann C. Dee

	Name:	 	Ann C. Dee
	Title:	 	Executive Vice President, General Counsel and Corporate Secretary

  
 [Signature Page to
Eleventh Supplemental Indenture] 

 
					
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
			
		 	By:	 	 /s/ R. Tarnas

		 	Name:	 	R. Tarnas
		 	Title:	 	Vice President

  
 [Signature Page to
Eleventh Supplemental Indenture] 

 EXHIBIT A 

[FACE OF NOTE] 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION
(“DTC”), TO THE ISSUER OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC
AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC, ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 UNLESS AND UNTIL THIS CERTIFICATE IS EXCHANGED IN
WHOLE OR IN PART FOR NOTES IN CERTIFICATED FORM, THIS CERTIFICATE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY DTC TO A NOMINEE THEREOF OR BY A NOMINEE THEREOF TO DTC OR ANOTHER NOMINEE OF DTC OR BY DTC OR ANY SUCH NOMINEE TO A SUCCESSOR OF DTC OR A
NOMINEE OF SUCH SUCCESSOR. 
  

			
	 REGISTERED
	  	REGISTERED
		
	 NO. 1
	  	PRINCIPAL AMOUNT
		
	 CUSIP NO. 264411 AD1
	  	$250,000,000

 DUKE REALTY LIMITED PARTNERSHIP 

3.875% Senior Notes due 2021 

Duke Realty Limited Partnership, an Indiana limited partnership (the “Issuer,” which term includes any successor
under the Indenture hereinafter referred to), for value received, hereby promises to pay to Cede & Co. or its registered assigns, the principal sum of Two Hundred Fifty Million dollars on February 15, 2021 (the “Maturity
Date”), and to pay interest thereon from December 3, 2013 (or from the most recent interest payment date to which interest has been paid or duly provided for) in U.S. dollars semi-annually in arrears on February 15 and August 15
of each year, each, an “Interest Payment Date”, commencing on August 15, 2014, and on the Maturity Date, at the rate of 3.875% per annum, until payment of said principal sum has been made or duly provided for. 

 The interest so payable and punctually paid or duly provided for on any Interest
Payment Date and on the Maturity Date will be paid to the Holder in whose name this Note (or one or more predecessor Notes) is registered at the close of business on the “Record Date” for such payment, which will be 15 days (regardless of
whether such day is a Business Day (as defined below)) prior to such payment date or the Maturity Date, as the case may be. Any interest not so punctually paid or duly provided for shall forthwith cease to be payable to the Holder on such Record
Date, and shall be paid to the Holder in whose name this Note (or one or more predecessor Notes) is registered at the close of business on a subsequent Record Date for the payment of such defaulted interest (which shall be not less than five
Business Days (as defined below) prior to the date of the payment of such defaulted interest) established by notice given by mail by or on behalf of the Issuer to the Holders of the Notes not less than 15 days preceding such subsequent Record Date.
Interest on this Note will be computed on the basis of a 360-day year of twelve 30-day months. 
 The principal of this Note
payable on the Maturity Date will be paid against presentation and surrender of this Note at the office or agency of the Issuer maintained for that purpose. The Issuer hereby initially designates the Corporate Trust Office of the Trustee at Global
Corporate Trust, 2. N. LaSalle Street, Suite 1020, Chicago, Illinois 60602 as the office to be maintained by it where Notes may be presented for payment, registration of transfer, or exchange and where notices or demands to or upon the Issuer in
respect of the Notes or the Indenture referred to on the reverse hereof may be served. 
 Interest payable on this Note on
any Interest Payment Date and on the Maturity Date, as the case may be, will be the amount of interest accrued from and including the immediately preceding Interest Payment Date (or from and including December 3, 2013) in the case of the
initial Interest Payment Date) to but excluding the applicable Interest Payment Date or the Maturity Date, as the case may be. If any Interest Payment Date or the Maturity Date falls on a day that is not a Business Day (as defined below), the
required payment of interest or principal or both, as the case may be, will be made on the next Business Day with the same force and effect as if it were made on the date such payment was due and no interest will accrue on the amount so payable for
the period from and after such Interest Payment Date or the Maturity Date, as the case may be. “Business Day” means any day, other than a Saturday or a Sunday, on which banking institutions in The City of New York are open for business.

 Payments of principal and interest in respect of this Note will be made by wire transfer of immediately available funds
in such coin or currency of the United States of America as at the time of payment is legal tender for the payment of public and private debts. 

Reference is made to the further provisions of this Note set forth on the reverse hereof. Such further provisions shall for
all purposes have the same effect as though fully set forth at this place. 
 This Note shall not be entitled to the
benefits of the Indenture referred to on the reverse hereof or be valid or become obligatory for any purpose until the certificate of authentication hereon shall have been signed by the Trustee under such Indenture. 

 IN WITNESS WHEREOF, the Issuer has caused this instrument to be signed manually
or by facsimile by its authorized officers. 
 Dated as of:             , 2013 

 

					
	DUKE REALTY LIMITED PARTNERSHIP,
		 	 as Issuer

		
	 By:
	 	 DUKE REALTY CORPORATION,

		 	 its General Partner

		
	 By:
	 	  

		 	 Name:
	 	 Mark A. Denien

		 	 Title:
	 	Executive Vice President and Chief Financial Officer
		
	 By:
	 	  

		 	 Name:
	 	 Ann C. Dee

		 	 Title:
	 	Executive Vice President, General Counsel and Corporate Secretary

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated herein referred to in the within-mentioned Indenture. 

 

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
		
	 By:
	 	  

		 	 Authorized Officer

 

			
	 Dated:
	 	             , 2013

 [REVERSE OF NOTE] 

DUKE REALTY LIMITED PARTNERSHIP 

3.875% Senior Notes due 2021 

This security is one of a duly authorized issue of debentures, notes, bonds, or other evidences of indebtedness of the Issuer
(hereinafter called the “Securities”) of the series hereinafter specified, all issued or to be issued under and pursuant to an Indenture dated as of July 28, 2006 (hereinafter called the “Indenture”), duly executed and
delivered by the Issuer to The Bank of New York Mellon Trust Company, N.A. (as successor to J.P. Morgan Trust Company, National Association), as Trustee (hereinafter called the “Trustee,” which term includes any successor trustee under the
Indenture with respect to the series of Securities of which this Note is a part), to which the Indenture and all indentures supplemental thereto relating to this security reference is hereby made for a description of the rights, limitations of
rights, obligations, duties, and immunities thereunder of the Trustee, the Issuer, and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. The Securities may be issued in one or
more series, which different series may be issued in various aggregate principal amounts, may mature at different times, may bear interest (if any) at different rates, may be subject to different redemption provisions (if any), and may otherwise
vary as provided in the Indenture or any indenture supplemental thereto. This security is one of a series designated as the 3.875% Senior Notes due February 15, 2021 of the Issuer, initially limited in aggregate principal amount to
$250,000,000. 
 In case an Event of Default with respect to this security shall have occurred and be continuing, the
principal hereof and Make-Whole Amount, if any, may be declared, and upon such declaration shall become, due and payable, in the manner, with the effect, and subject to the conditions provided in the Indenture. 

The Issuer may redeem this security at any time at the option of the Issuer, in whole or in part, at a redemption price equal
to the sum of (i) the principal amount of this security being redeemed and (ii) the Make-Whole Amount, if any, with respect to this security, in either case plus accrued and unpaid interest thereon to, but excluding, the Redemption Date
(the “Redemption Price”); provided, however, that if the Redemption Date is any time on or after December 15, 2020, the Redemption Price shall mean the principal amount of the Notes being redeemed plus accrued and unpaid interest
thereon to, but excluding, the Redemption Date. Notice of any optional redemption of any Securities will be given to Holders at their addresses, as shown in the Security Register, not more than 60 days nor less than 30 days prior to the date fixed
for redemption. The notice of redemption will specify, among other items, the Redemption Price and the principal amount of the Securities held by such Holder to be redeemed. 

The Indenture contains provisions permitting the Issuer and the Trustee, with the consent of the Holders of not less than a
majority of the aggregate principal amount of the Securities at the time outstanding of all series to be affected (voting as one class), evidenced as provided in the Indenture, to execute supplemental indentures adding any provisions to or changing
in any manner or eliminating any of the provisions of the Indenture or of any supplemental indenture or modifying in any manner the rights of the Holders of the Securities of each series; provided, however, that no such supplemental indenture shall,
without the consent of the Holder of each Security so affected, (i) change the Stated Maturity of the principal of (or premium, if any, on) or any installment of principal 

 
of or interest on, any Security, or reduce the principal amount thereof or the rate or amount of interest thereon or any premium payable upon the redemption thereof, or adversely affect any right
of repayment at the option of the Holder of any Security, or change any Place of Payment where, or the currency or currencies, currency unit or units or composite currency or currencies in which, any Security or any premium or the interest thereon
is payable, or impair the right to institute suit for the enforcement of any such payment on or after the Stated Maturity thereof, or (ii) reduce the aforesaid percentage of Securities, the Holders of which are required to consent to any such
supplemental indenture, or (iii) reduce the percentage of Securities, the Holders of which are required to consent to any waiver of compliance with certain provisions of the Indenture or any waiver of certain defaults thereunder. It is also
provided in the Indenture that, with respect to certain defaults or Events of Default regarding the Securities of any series, the Holders of a majority in aggregate principal amount outstanding of the Securities of such series (or, in the case of
certain defaults or Events of Default, all series of Securities) may on behalf of the Holders of all the Securities of such series (or all of the Securities, as the case may be) waive any such past default or Event of Default and its consequences,
prior to any declaration accelerating the maturity of such Securities, or, subject to certain conditions, may rescind a declaration of acceleration and its consequences with respect to such Securities. Any such consent or waiver by the Holder of
this security (unless revoked as provided in the Indenture) shall be conclusive and binding upon such Holder and upon all future Holders and owners of the security and any securities that may be issued in exchange or substitution herefor,
irrespective of whether or not any notation thereof is made upon this security or such other securities. 
 No reference
herein to the Indenture and no provision of this security or of the Indenture shall alter or impair the obligation of the Issuer, which is absolute and unconditional, to pay the principal of and any Make-Whole Amount and interest on this security in
the manner, at the respective times, at the rate and in the coin or currency herein prescribed. 
 This security is issuable
only in registered form without coupons in denominations of $1,000 and integral multiples thereof. Securities may be exchanged for a like aggregate principal amount of securities of this series of other authorized denominations at the office or
agency of the Issuer, in the manner and subject to the limitations provided in the Indenture, but without the payment of any service charge except for any tax or other governmental charge imposed in connection therewith. 

Upon due presentment for registration of transfer of Securities at the office or agency of the Issuer, one or more new
Securities of the same series of authorized denominations in an equal aggregate principal amount will be issued to the transferee in exchange therefor, subject to the limitations provided in the Indenture, without charge except for any tax or other
governmental charge imposed in connection therewith. 
 The Issuer, the Trustee or any authorized agent of the Issuer or the
Trustee may deem and treat the Person in whose name this security is registered as the absolute owner of this security (whether or not this security shall be overdue and notwithstanding any notation of ownership or other writing hereon), for the
purpose of receiving payment of, or on account of, the principal hereof and Make-Whole Amount, if any, and subject to the provisions on the face hereof, interest hereon, and for all other purposes, and neither the Issuer nor the Trustee nor any
authorized agent of the Issuer or the Trustee shall be affected by any notice to the contrary. 

 The Indenture and each Security shall be deemed to be a contract under the laws
of the State of New York, and for all purposes shall be construed in accordance with the laws of such state, except as may otherwise be required by mandatory provisions of law. 

Capitalized terms used herein which are not otherwise defined shall have the respective meanings assigned to them in the
Indenture and all indentures supplemental thereto relating to this security.

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