Document:

First Supplemental Indenture

 Exhibit 4.3 
 ZOETIS INC. 
 FIRST SUPPLEMENTAL INDENTURE 

Dated as of January 28, 2013 
 1.150% Senior Notes due 2016 
 1.875% Senior Notes due 2018

 3.250% Senior Notes due 2023 
 4.700% Senior Notes due 2043 
 (First Supplemental Indenture to the
Indenture Dated as of January 28, 2013) 
 DEUTSCHE BANK TRUST COMPANY AMERICAS, 

as Trustee 

 FIRST SUPPLEMENTAL INDENTURE 

FIRST SUPPLEMENTAL INDENTURE (this “First Supplemental Indenture”), dated as of January 28, 2013, between Zoetis
Inc., a Delaware corporation (the “Company”), and Deutsche Bank Trust Company Americas, a New York banking corporation, as Trustee (the “Trustee”). 

RECITALS: 

WHEREAS, the Company and the Trustee executed and delivered an Indenture, dated as of January 28, 2013 (the
“Indenture”), to provide for the issuance by the Company from time to time of Securities to be issued in one or mores series as provided in the Indenture; 
 WHEREAS, the issuance and sale of $400,000,000 aggregate principal amount of a new series of the Securities of the Company designated as its 1.150% Senior Notes due 2016 (the “2016
Notes”), $750,000,000 aggregate principal amount of a new series of the Securities of the Company designated as its 1.875% Senior Notes due 2018 (the “2018 Notes”), $1,350,000,000 aggregate principal amount of a new series
of the Securities of the Company designated as its 3.250% Senior Notes due 2023 (the “2023 Notes”) and $1,150,000,000 aggregate principal amount of a new series of the Securities of the Company designated as its 4.700% Senior Notes
due 2043 (the “2043 Notes” and, together with the 2016 Notes, the 2018 Notes and the 2023 Notes, and, if and when issued, any Additional Notes, together with any Exchange Notes issued therefor, as provided herein, the
“Notes”) have been authorized by resolutions adopted by the Board of Directors of the Company; 
 WHEREAS, the
Company desires to issue and sell $3,650,000,000 aggregate principal amount of the Notes on the date hereof; 
 WHEREAS,
Sections 2.01 and 10.01 of the Indenture provide that the Company, when authorized by a Board Resolution, and the Trustee may amend or supplement the Indenture to provide for the issuance of and to establish the form or terms and conditions of
Securities of any series as permitted by the Indenture; 
 WHEREAS, the Company desires to establish the form, terms and
conditions of the Notes; and 
 WHEREAS, all things necessary to make this First Supplemental Indenture a legal, valid and
binding supplement to the Indenture according to its terms and the terms of the Indenture have been done; 
 NOW, THEREFORE, for
and in consideration of the premises stated herein and the purchase of the Notes by the Holders thereof, the parties hereto 

 
hereby enter into this First Supplemental Indenture, for the equal and proportionate benefit of all Holders of the Notes, as follows: 

ARTICLE 1 

DEFINITIONS 
 Section 1.01. Certain Terms Defined in the Indenture; Additional Terms. For purposes of this First Supplemental Indenture, all capitalized terms used but not defined herein shall have the
meanings ascribed to such terms in the Indenture, as amended hereby. The following capitalized terms used herein shall be defined accordingly: 
 “Agent Member” means a member of, or a participant in, the Depository. 
 “Certificated Note” means a Note in registered certificated form. 

“Certificate of Beneficial Ownership” means a certificate substantially in the form of Exhibit I. 

“DTC Legend” means the legend set forth in Exhibit F. 

“Exchange Notes” means the Notes of the Company issued pursuant to the Indenture in exchange for, and in an aggregate
principal amount equal to, the Initial Notes, in compliance with the terms of the Registration Rights Agreement and containing terms substantially identical to the Initial Notes (except that (i) such Exchange Notes will be registered under the
Securities Act and will not be subject to transfer restrictions or bear the Restricted Securities Legend, and (ii) the provisions relating to rights under the Registration Rights Agreement will be eliminated). 

“Exchange Offer” means the registered exchange offer to the holders of the Notes conducted by the Company in accordance
with the terms of the Registration Rights Agreement. 
 “Global Note” means a Note in registered global form.

 “Initial Additional Notes” means Additional Notes issued in an offering not registered under the Securities
Act and any Notes issued in replacement thereof, but not including any Exchange Notes issued in exchange therefor. 

“Initial Notes” means the Notes issued on the Issue Date and any Notes issued in replacement thereof, but not including
any Exchange Notes issued in exchange therefor. 

  
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 “Initial Purchasers” means the initial purchasers party to a purchase
agreement dated January 16, 2013 with the Company and the selling noteholders named therein (the “Selling Noteholders”) relating to the sale of the Notes by the Company, (other than the $1,000,000,000 aggregate principal amount
of the 2023 Notes) and, with respect to such $1,000,000,000 aggregate principal amount of the 2023 Notes, by the Selling Noteholders. 
 “Issue Date” means the date on which the Notes are originally issued under this Indenture. 
 “Offshore Global Note” means a Global Note representing Notes issued and sold pursuant to Regulation S. 
 “Permanent Offshore Global Note” means an Offshore Global Note that does not bear the Temporary Offshore Global Note Legend. 

“Registration Rights Agreement” means the Registration Rights Agreement dated January 28, 2013 among the Company
and the Initial Purchasers party thereto with respect to the Initial Notes. 
 “Regulation S” means Regulation
S under the Securities Act. 
 “Regulation S Certificate” means a certificate substantially in the form of
Exhibit G hereto. 
 “Regulation S Global Note” means a Global Note bearing a Restricted Security Legend and
representing Notes sold pursuant to Regulation S. 
 “Restricted Global Note” means a Rule 144A Global Note or
a Regulation S Global Note. 
 “Restricted Legend” means the legend set forth in Exhibit E. 

“Restricted Note” means a Note bearing a Restricted Security Legend. 

“Restricted Period” means the period beginning on the date hereof and ending 40 days thereafter. 

“Rule 144A” means Rule 144A under the Securities Act. 

“Rule 144A Certificate” means (i) a certificate substantially in the form of Exhibit H hereto or (ii) a
written certification addressed to the Company and the Trustee to the effect that the Person making such certification (x) is acquiring such Note (or beneficial interest) for its own account or one or more accounts with respect to which it
exercises sole investment discretion and that it and each such account is a qualified institutional buyer within the meaning of Rule 144A, 

  
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(y) is aware that the transfer to it or exchange, as applicable, is being made in reliance upon the exemption from the provisions of Section 5 of the Securities Act provided by Rule 144A,
and (z) acknowledges that it has received such information regarding the Company as it has requested pursuant to Rule 144A(d)(4) or has determined not to request such information. 

“Rule 144A Global Note” means a Global Note that bears the Restricted Legend representing Notes sold pursuant to
Rule 144A. 
 “Securities Act” means the Securities Act of 1933, as amended. 

“Temporary Offshore Global Note” means an Offshore Global Note that bears the Temporary Offshore Global Note Legend.

 “Temporary Offshore Global Note Legend” means the legend set forth in Exhibit J. 

“Transfer Certification” means a certification substantially in the form identified as the “Transfer
Certification” in the forms of Notes attached as Exhibits A, B, C and D hereto. 
 “Unrestricted Global
Note” means a Global Note that does not bear the Restricted Security Legend. 
 “U.S. Global Note”
means a Global Note that bears the Restricted Legend representing Notes issued and sold pursuant to Rule 144A. 

Section 1.02. Definitions Incorporated into the Indenture. For the benefit of the Holders of the Notes, Section 1.01 of
the Indenture shall be amended by adding the following new definitions: 
 “Additional Notes” shall have the
meaning set forth in Section 2.06(b) of this Indenture 
 “Below Investment Grade Rating Event” means
Notes are rated below Investment Grade Rating by both of the Rating Agencies on any date commencing upon the first public notice by the Company of the occurrence of a Change of Control and ending 60 days following consummation of such Change of
Control (which period shall be extended up to an additional 60 days, so long as the rating of the Notes is under publicly announced consideration for possible downgrade by either of the Rating Agencies); provided that a Below Investment Grade
Rating Event will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a Below Investment Grade Rating Event for purposes of the definition of Change of Control Triggering Event) if each Rating
Agency making the reduction in rating does not publicly announce or confirm or inform the Company in writing at its request that the 

  
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reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the Change of Control. 

“Change of Control” means the occurrence of any of the following: (1) the direct or indirect sale, transfer,
conveyance or other disposition (other than by way of merger or consolidation), in one or more series of related transactions, of all or substantially all of the assets of the Company and the assets of its Subsidiaries, taken as a whole, to one or
more “persons” (as that term is used in Section 13(d)(3) of the Exchange Act) (other than to the Company or one of its Subsidiaries); (2) the consummation of any transaction (including, without limitation, any merger or
consolidation, but excluding, transactions in connection with the Distribution) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act ) (other than Pfizer or one of its Affiliates)
becomes the beneficial owner (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the voting stock of the Company or other voting stock into which the voting stock of the Company is reclassified,
consolidated, exchanged or changed, measured by voting power rather than number of shares; provided, however, that a transaction will not be deemed to involve a Change of Control if (a) the Company becomes a direct or indirect wholly
owned subsidiary of a holding company and (b)(i) the holders of the voting stock of such holding company immediately following that transaction are substantially the same as the holders of the voting stock of the Company immediately prior to that
transaction or (ii) no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more
than 50% of the voting power of the voting stock of such holding company immediately following such transaction; (3) the Company consolidates with, or merges with or into, any “person” or “group” (as that term is used in
Section 13(d)(3) of the Exchange Act) or any such person or group consolidates with, or merges with or into, the Company, in either case, pursuant to a transaction in which any of the Company’s outstanding voting stock or the voting stock
of such other person is converted into or exchanged for cash, securities or other property, other than pursuant to a transaction in which shares of the voting stock of the Company outstanding immediately prior to the transaction constitute, or are
converted into or exchanged for, a majority of the voting stock of the surviving person immediately after giving effect to such transaction; (4) the first day on which a majority of the members of the Board of Directors of the Company are not
Continuing Directors; or (5) the adoption of a plan relating to the Company’s liquidation or dissolution; provided that for purposes of this definition “voting stock” means with respect to any specified person (as that term is
used in Section 13(d)(3) of the Exchange Act) capital stock of any class or kind the holders of which are ordinarily, in the absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of
such person, even if the right to vote has been suspended by the happening of such a contingency. 

  
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 “Change of Control Offer” shall have the meaning set forth in
Section 3.09 of this Indenture. 
 “Change of Control Payment” shall have the meaning set forth in
Section 3.09 of this Indenture. 
 “Change of Control Payment Date” shall have the meaning set forth in
Section 3.09 of this Indenture. 
 “Change of Control Triggering Event” means the occurrence of both a
Change of Control and a Below Investment Grade Rating Event. 
 “Comparable Treasury Issue” means, for any
series of Notes, the United States Treasury security selected by an Independent Investment Banker as having a maturity comparable to the remaining term of the Notes of such series to be redeemed that would be utilized, at the time of selection and
in accordance with customary financial practice, in pricing new issues of corporate debt securities of a comparable maturity to the remaining term of the Notes of such series. 
 “Comparable Treasury Price” means, with respect to any Redemption Date, and series of Notes to be redeemed,, (A) the average of the Reference Treasury Dealer Quotations for such
Redemption Date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, (B) if the Independent Investment Banker obtains fewer than four such Reference Treasury Dealer Quotations, the average of such quotations, or
(C) if only one such Reference Treasury Dealer Quotation is received, such Reference Treasury Dealer Quotation. 

“Consolidated Net Tangible Assets” means the aggregate amount of assets after deducting (a) all current liabilities
(excluding any indebtedness maturing within 12 months of the end of the most recent quarter for which financial statements are available) and (b) all goodwill, trade names, patents, unamortized debt discount and expense and any other like
intangibles. 
 “Continuing Director” means, as of any date of determination, any member of the Board of
Directors of the Company who (1) was a member of such Board of Directors on the date the Notes were originally issued, or (2) was nominated for election, or elected to such Board of Directors with the approval of a majority of the
Continuing Directors who were members of the Board of Directors of the Company at the time of such nomination or election (either by a specific vote or by approval of the proxy statement of the Company in which such member was named as a nominee for
election as a director). 
 “Debt” of any Person means (a) all obligations of such Person for borrowed
money, or evidenced by bonds, debentures, notes or other similar instruments (other than any such obligations to the extent that (i) the liability of 

  
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such Person is limited solely to the property or asset financed by such obligations or (ii) such obligations result from the requirement to return collateral posted to such Person by a
counterparty pursuant to one or more hedging contracts or other similar risk management contracts) and (b) all Debt of others guaranteed by such Person. 
 “Distribution” means, following the initial public offering of the Company’s Class A Common Stock, a tax-free distribution by Pfizer to its stockholders of all or a portion of
its remaining equity interest in the Company, which may include one or more distributions effected as a dividend to all Pfizer stockholders, one or more distributions in exchange for Pfizer shares or other securities, or any combination thereof.

 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company to act as the
“Independent Investment Banker.” 
 “Initial Lien” shall have the meaning set forth in
Section 2.09 of this Indenture 
 “Investment Grade Rating” means a rating by Moody’s equal to or
higher than Baa3 (or the equivalent under a successor rating category of Moody’s) or a rating by S&P equal to or higher than BBB- (or the equivalent under any successor rating category of S&P). 

“Lien” means, with respect to any property of any Person, any mortgage or deed of trust, pledge, hypothecation,
assignment, deposit arrangement, security interest, lien, charge, easement (other than any easement not materially impairing usefulness or marketability), encumbrance, preference, priority or other security agreement or preferential arrangement of
any kind or nature whatsoever on or with respect to such property. 
 “Moody’s” means Moody’s
Investors Service, Inc., and any successor to its rating agency business. 
 “Notes” shall have the meaning set
forth in the preamble to this Indenture 
 “Permitted Liens” means (1) Liens existing on the date of this
First Supplemental Indenture or Liens existing on facilities of any Person at the time it becomes a Subsidiary of the Company; (2) Liens on property owned by a Person existing at the time such Person is merged with or into or consolidated with
the Company or any of its Subsidiaries; provided that such Liens were in existence prior to the contemplation of such merger or consolidation and do not extend to any assets other than those of the Person merged into or consolidated with the

  
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Company or such Subsidiary; (3) Liens on property existing at the time of acquisition thereof by the Company or any of its Subsidiaries; provided that such Liens were in existence
prior to the contemplation of such acquisition and do not extend to any property other than the property so acquired by the Company or such Subsidiary; (4) a Lien on any asset or improvement to any asset securing Debt incurred or assumed for
the purpose of financing all or any part of the cost of acquiring or improving (including constructing) such asset, if such Lien attaches to such asset concurrently with or within 12 months after its acquisition or improvement (including the
completion of construction) and the principal amount of the Debt secured by such Lien, together with all other Debt secured by a Lien on such property, does not exceed the purchase price of such property or the cost of such improvement; (5) any
Lien arising by reason of deposits with, or the giving of any form of security to, any governmental agency or any body created or approved by law or governmental regulation; (6) Liens securing Debt of a Restricted Subsidiary of the Company owed
to the Company or another Restricted Subsidiary of the Company; (7) any extension, renewal or replacement (or successive extensions, renewals or replacements) in whole or in part of any Lien referred to in clauses (1) through
(6) above, inclusive, so long as (i) the principal amount of the Debt secured thereby does not exceed the principal amount of Debt so secured at the time of the extension, renewal or replacement (except that, where an additional principal
amount of Debt is incurred to provide funds for the completion of a specific project, the additional principal amount, and any related financing costs, may be secured by the Lien as well) and (ii) the Lien is limited to the same property
subject to the Lien so extended, renewed or replaced (and improvements on the property); and (8) Liens on any Principal Property not described in clauses (1) through (7) above securing Debt that, together with (i) the aggregate
amount of all other outstanding Debt secured by all other Liens on Principal Property not described in clauses (1) through (7) above and (ii) the aggregate amount of Value in respect of all Sale and Leaseback Transactions that would
otherwise be prohibited by Section 2.09 hereof do not exceed 15% of the Company’s Consolidated Net Tangible Assets measured as of the end of the most recent quarter for which financial statements are available. 

“Pfizer” means Pfizer Inc., a Delaware corporation. 

“Principal Property” means any building, structure or other facility together with the underlying land and its fixtures,
used primarily for manufacturing, processing or production, owned in the United States and the net book value of such building, structure or other facility exceeds 2% of the Company’s Consolidated Net Tangible Assets measured as of the end of
the most recent quarter for which financial statements are available; provided that no building, structure or other facility will be a Principal Property if, in the good faith opinion of the Board of Directors of the Company (or a committee
thereof), such building, structure or other facility is not of material importance to the Company’s business taken as a whole. 

  
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 “Rating Agencies” means (1) Moody’s and S&P; and (2) if
either or both of Moody’s or S&P ceases to rate the notes or fails to make a rating of the notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization”
within the meaning of Section 3(a)(62) under the Exchange Act, selected by the Company (as certified by a resolution of the Board of Directors of the Company) as a replacement agency for either Moody’s, S&P, or both of them, as the
case may be 
 “Reference Treasury Dealer” means (A) each of Merrill Lynch, Pierce, Fenner &
Smith Incorporated, Barclays Capital Inc., J.P. Morgan Securities LLC, and Deutsche Bank Securities Inc. (or their respective affiliates that are Primary Treasury Dealers), and their respective successors; provided, however, that if any of
the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any other Primary
Treasury Dealer(s) selected by the Company. 
 “Reference Treasury Dealer Quotation” means, with respect to
each Reference Treasury Dealer and any Redemption Date of series of Notes to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a
percentage of its principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. New York City time on the third Business Day preceding such Redemption Date. 

“Restricted Subsidiary” means any of the Company’s Subsidiaries that owns a Principal Property. 

“S&P” means Standard & Poor’s Rating Services, a Standard & Poor’s Financial Services
LLC business, and any successor to its rating agency business. 
 “Sale and Leaseback Transaction” means any
direct or indirect arrangement relating to property now owned or hereafter acquired whereby the Company or a Restricted Subsidiary transfers such property to another Person and the Company or a Restricted Subsidiary leases or rents it from such
Person (other than (i) leases between the Company and a Restricted Subsidiary or between Restricted Subsidiaries, (ii) temporary leases for a term, including renewals at the option of the lessee, of not more than three years and
(iii) leases of a property executed by the time of, or within 90 days after the latest of, the acquisition, the completion of construction or improvement, or the commencement of commercial operation of the property). 

“Special Mandatory Redemption Date” means the date which is 30 business days after a Special Mandatory Redemption
Trigger Date. 

  
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 “Special Mandatory Redemption Price” means, with respect to any series of
notes, 101% of the aggregate principal amount of the Notes together with accrued and unpaid interest to, but excluding, the Special Mandatory Redemption Date. 
 “Special Mandatory Redemption Trigger Date” shall have the meaning set forth in Section 3.10 of this Indenture. 

“Treasury Rate” means, with respect to any Redemption Date for any series of Notes, the rate per annum equal to the
semi-annual equivalent yield to maturity of the applicable Comparable Treasury Issue, assuming a price for the applicable Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the applicable Comparable Treasury Price
for such Redemption Date. 
 “Value” means, with respect to a Sale and Leaseback Transaction, an amount equal
to the present value of the lease payments with respect to the term of the lease remaining on the date as of which the amount is being determined, without regard to any renewal or extension options contained in the lease, discounted at the weighted
average interest rate of all series of Securities issued pursuant to the Indenture and having the benefit of the covenants described in Sectiond 5.06 and 5.07 of this Indenture (including the effective interest rate of any original issue discount
Securities) which are outstanding on the date of such Sale and Leaseback Transaction. 
 Section 1.03. As used in
the Indenture, for the purpose of the Notes, the term “interest” shall be deemed to include any “Additional Interest” payable as a consequence of a “Registration Default,” in each case as defined in, and in accordance
with, the Registration Rights Agreement.  
 ARTICLE 2 

FORM AND TERMS OF THE NOTES 

Section 2.01. Form and Dating. (a) The 2016 Notes and the Trustee’s certificate of authentication shall be
substantially in the form of Exhibit A attached hereto. The 2018 Notes and the Trustee’s certificate of authentication shall be substantially in the form of Exhibit B attached hereto. The 2023 Notes and the Trustee’s certificate of
authentication shall be substantially in the form of Exhibit C attached hereto. The 2043 Notes and the Trustee’s certificate of authentication shall be substantially in the form of Exhibit D attached hereto. The Notes shall be executed on
behalf of the Company by any Officer and attested by its Secretary or one of its Assistant Secretaries. The signature of any of these Officers on the Notes may be manual or facsimile. The Notes may have notations, legends or endorsements required by
law, stock exchange rules or usage. Each 

  
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Note shall be dated the date of its authentication. The Notes shall be in denominations of $2,000 and higher integral multiples of $1,000 in excess thereof. 

The terms and notations contained in the Notes shall constitute, and are hereby expressly made, a part of the Indenture as supplemented
by this First Supplemental Indenture and the Company and the Trustee, by their execution and delivery of this First Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. 

(b) (i) Except as otherwise provided in paragraph (c), Section 2.04(b)(iii), Section 2.04(b)(v), Section 2.04(c) or
Section 2.03(a)(iii), each Initial Note or Additional Note (other than a Permanent Offshore Global Note) will bear the Restricted Legend. 
 (ii) Each Global Note, whether or not an Initial Note or Additional Note, will bear the DTC Legend. 
 (iii) Each Temporary Offshore Global Note will bear the Temporary Offshore Global Note Legend. 
 (iv) Initial Notes and Additional Notes offered and sold in reliance on Regulation S will be issued as provided in Section 2.05(a). 

(v) Initial Notes and Additional Notes offered and sold in reliance on any exception under the Securities Act other than
Regulation S and Rule 144A will be issued, and upon the request of the Company to the Trustee, Initial Notes offered and sold in reliance on Rule 144A may be issued, in the form of Certificated Notes. 

(c) (i) If the Company determines (upon the advice of counsel and such other certifications and evidence as the Company may reasonably
require) that a Note is eligible for resale pursuant to Rule 144 under the Securities Act (or a successor provision) without compliance with any limits thereunder and that the Restricted Legend is no longer necessary or appropriate in order to
ensure that subsequent transfers of the Note (or a beneficial interest therein) are effected in compliance with the Securities Act, 
 (ii) after an Initial Note or any Initial Additional Note is (x) sold pursuant to an effective registration statement under the Securities Act, pursuant to the Registration Rights Agreement or
otherwise, or (y) is validly tendered for exchange into an Exchange Note pursuant to an Exchange Offer, 
 the Company may instruct the
Trustee in an Officers’ Certificate to cancel the Note and issue to the Holder thereof (or to its transferee) a new Note of like tenor 

  
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and amount, registered in the name of the Holder thereof (or its transferee), that does not bear the Restricted Legend, and the Trustee will comply with such instruction. 

(d) By its acceptance of any Note bearing the Restricted Legend (or any beneficial interest in such a Note), each Holder thereof and each
owner of a beneficial interest therein acknowledges the restrictions on transfer of such Note (and any such beneficial interest) set forth in this Indenture and in the Restricted Legend and agrees that it will transfer such Note (and any such
beneficial interest) only in accordance with this Indenture and such legend. 
 Section 2.02. Paying Agent; Depository.
(a) The Company appoints the Trustee as the initial agent of the Company for the payment of the principal of (and premium, if any) and interest on the Notes, and the office of the Trustee located in the Borough of Manhattan, the City of New
York, be and hereby is, designated as the office or agency where the Notes may be presented for payment and where notices to or demands upon the Company in respect of the Notes and the Indenture pursuant to which the Notes are to be issued may be
served. The Company may at any time designate additional Paying Agents or rescind the designation of any Paying Agent or approve a change in the office through which the Paying Agent acts. 

(b) The Depository shall initially be DTC and any and all successors thereto appointed as Depository by the Company. 

Section 2.03. Registration, Transfer and Exchange. (a) Each Global Note will be registered in the name of the Depository
or its nominee and, so long as DTC is serving as the Depository thereof, will bear the DTC Legend. 
 (i) Each
Global Note will be delivered to the Trustee as custodian for the Depository. Transfers of a Global Note (but not a beneficial interest therein) will be limited to transfers thereof in whole, but not in part, to the Depository, its successors or
their respective nominees, except (y) as set forth in (iii) of this Section 2.03(a) and (z) transfers of portions thereof in the form of Certificated Notes may be made upon request of an Agent Member (for itself or on behalf of a
beneficial owner) by written notice given to the Trustee by or on behalf of the Depository in accordance with customary procedures of the Depository and in compliance with this Section 2.03 and Section 2.04. 

(ii) Agent Members will have no rights under this Indenture with respect to any Global Note held on their behalf by the
Depository, and the Depository may be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute owner and Holder of such Global Note for all purposes whatsoever. Notwithstanding the

  
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foregoing, the Depository or its nominee may grant proxies and otherwise authorize any Person (including any Agent Member and any Person that holds a beneficial interest in a Global Note through
an Agent Member) to take any action which a Holder is entitled to take under this Indenture or the Notes, and nothing herein will impair, as between the Depository and its Agent Members, the operation of customary practices governing the exercise of
the rights of a holder of any security. 
 (iii) If (x) the Depository notifies the Company that it is
unwilling or unable to continue as Depository for a Global Note and a successor depositary is not appointed by the Company within 90 days of such notice or (y) an Event of Default has occurred and is continuing and the Trustee has received a
written request from the Depository, the Trustee will promptly exchange each beneficial interest in the Global Note for one or more Certificated Notes in authorized denominations having an equal aggregate principal amount registered in the name of
the owner of such beneficial interest, as identified to the Trustee by the Depository, and thereupon the Global Note will be deemed canceled. If such Note does not bear the Restricted Legend, then the Certificated Notes issued in exchange therefor
will not bear the Restricted Legend. If such Note bears the Restricted Legend, then the Certificated Notes issued in exchange therefor will bear the Restricted Legend, provided that any Holder of any such Certificated Note issued in exchange
for a beneficial interest in a Temporary Offshore Global Note will have the right upon presentation to the Trustee of a duly completed Certificate of Beneficial Ownership after the Restricted Period to exchange such Certificated Note for a
Certificated Note of like tenor and amount that does not bear the Restricted Legend, registered in the name of such Holder. 

(b) Each Certificated Note will be registered in the name of the Holder thereof or its nominee. 

(c) (i) Global Note to Global Note. If a beneficial interest in a Global Note is transferred or exchanged for a beneficial
interest in another Global Note, the Trustee will (y) record a decrease in the principal amount of the Global Note being transferred or exchanged equal to the principal amount of such transfer or exchange and (z) record a like increase in
the principal amount of the other Global Note. Any beneficial interest in one Global Note that is transferred to a Person who takes delivery in the form of an interest in another Global Note, or exchanged for an interest in another Global Note,
will, upon transfer or exchange, cease to be an interest in such Global Note and become an interest in the other Global Note and, accordingly, will thereafter be subject to all transfer and exchange restrictions, if any, and other procedures
applicable to beneficial interests in such other Global Note for as long as it remains such an interest. 

  
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 (ii) Global Note to Certificated Note. If a beneficial interest in a
Global Note is transferred or exchanged for a Certificated Note, the Trustee will (y) record a decrease in the principal amount of such Global Note equal to the principal amount of such transfer or exchange and (z) deliver one or more new
Certificated Notes in authorized denominations having an equal aggregate principal amount to the transferee (in the case of a transfer) or the owner of such beneficial interest (in the case of an exchange), registered in the name of such transferee
or owner, as applicable. 
 (iii) Certificated Note to Global Note. If a Certificated Note is transferred
or exchanged for a beneficial interest in a Global Note, the Trustee will (x) cancel such Certificated Note, (y) record an increase in the principal amount of such Global Note equal to the principal amount of such transfer or exchange and
(z) in the event that such transfer or exchange involves less than the entire principal amount of the canceled Certificated Note, deliver to the Holder thereof one or more new Certificated Notes in authorized denominations having an aggregate
principal amount equal to the untransferred or unexchanged portion of the canceled Certificated Note, registered in the name of the Holder thereof. 
 (iv) Certificated Note to Certificated Note. If a Certificated Note is transferred or exchanged for another Certificated Note, the Trustee will (x) cancel the Certificated Note being
transferred or exchanged, (y) deliver one or more new Certificated Notes in authorized denominations having an aggregate principal amount equal to the principal amount of such transfer or exchange to the transferee (in the case of a transfer)
or the Holder of the canceled Certificated Note (in the case of an exchange), registered in the name of such transferee or Holder, as applicable, and (z) if such transfer or exchange involves less than the entire principal amount of the
canceled Certificated Note, deliver to the Holder thereof one or more Certificated Notes in authorized denominations having an aggregate principal amount equal to the untransferred or unexchanged portion of the canceled Certificated Note, registered
in the name of the Holder thereof. 
 Notwithstanding anything to the contrary herein, this Section 2.03 will become effective immediately
after the authentication and delivery of Global Notes evidencing $400,000,000 aggregate principal amount of the 2016 Notes, $750,000,000 aggregate principal amount of the 2018 Notes, $1,350,000,000 aggregate principal amount of the 2023 Notes and
$1,150,000,000 aggregate principal amount of the 2043 Notes. 
 Section 2.04. Restrictions on Transfer and Exchange.
(a) The transfer or exchange of any Note (or a beneficial interest therein) may only be made in accordance with this Section 2.04 and Section 2.03 and, in the case of a Global

  
 15 

 
Note (or a beneficial interest therein), the applicable rules and procedures of the Depository. The Security Registrar shall refuse to register any requested transfer or exchange that does not
comply with the preceding sentence. 
 (b) Subject to paragraph (c) of this Section 2.04, the transfer or exchange of
any Note (or a beneficial interest therein) of the type set forth in column A below for a Note (or a beneficial interest therein) of the type set forth opposite in column B below may only be made in compliance with the certification requirements (if
any) described in the clause of this paragraph set forth opposite in column C below. 
  

					
	 A
	  	 B
	  	 C

	U.S. Global Note	  	U.S. Global Note	  	(i)
	U.S. Global Note	  	Offshore Global Note	  	(ii)
	U.S. Global Note	  	Certificated Note	  	(iii)
	Offshore Global Note	  	U.S. Global Note	  	(iv)
	Offshore Global Note	  	Offshore Global Note	  	(i)
	Offshore Global Note	  	Certificated Note	  	(v)
	Certificated Note	  	U.S. Global Note	  	(iv)
	Certificated Note	  	Offshore Global Note	  	(ii)
	Certificated Note	  	Certificated Note	  	(iii)

 (i) No certification is required. 

(ii) The Person requesting the transfer or exchange must deliver or cause to be delivered to the Security Registrar a duly
completed Regulation S Certificate; provided that if the requested transfer or exchange is made by the Holder of a Certificated Note that does not bear the Restricted Legend, then no certification is required. 

(iii) The Person requesting the transfer or exchange must deliver or cause to be delivered to the Trustee (y) a duly
completed Rule 144A Certificate or (z) a duly completed Regulation S Certificate, and/or an Opinion of Counsel and such other certifications and evidence as the Company may reasonably require in order to determine that the proposed transfer or
exchange is being made in compliance with the Securities Act and any applicable securities laws of any state of the United States; provided that if the requested transfer or exchange is made by the Holder of a Certificated Note that does not
bear the Restricted Legend, then no certification is required. In the event that (y) the requested transfer or exchange takes place after the Restricted Period and a duly completed Regulation S Certificate is delivered to the Security Registrar
or (z) a Certificated Note that does not bear the Restricted Legend is surrendered for transfer or exchange, upon transfer or exchange the Trustee will deliver a Certificated Note that does not bear the Restricted Legend. 

  
 16 

 (iv) The Person requesting the transfer or exchange must deliver or cause to
be delivered to the Security Registrar a duly completed Rule 144A Certificate. 
 (v) Notwithstanding anything to
the contrary contained herein, no such exchange is permitted if the requested exchange involves a beneficial interest in a Temporary Offshore Global Note. If the requested transfer involves a beneficial interest in a Temporary Offshore Global Note,
the Person requesting the transfer must deliver or cause to be delivered to the Security Registrar a duly completed Rule 144A Certificate or and/or an Opinion of Counsel and such other certifications and evidence as the Company may reasonably
require in order to determine that the proposed transfer is being made in compliance with the Securities Act and any applicable securities laws of any state of the United States. If the requested transfer or exchange involves a beneficial interest
in a Permanent Offshore Global Note, no certification is required and the Trustee will deliver a Certificated Note that does not bear the Restricted Legend. 
 (c) No certification is required in connection with any transfer or exchange of any Note (or a beneficial interest therein): 

(i) after such Note is eligible for resale pursuant to Rule 144 under the Securities Act (or a successor provision)
without the need for current public information (within the meaning of Rule 144); provided that the Company has provided the Trustee with an Officer’s Certificate to that effect, and the Company may require from any Person requesting a
transfer or exchange in reliance upon this clause (i) an opinion of counsel and any other reasonable certifications and evidence in order to support such certificate; or 

(ii) (y) sold pursuant to an effective registration statement, pursuant to the Registration Rights Agreement or otherwise
or (z) which is validly tendered for exchange into an Exchange Note pursuant to an Exchange Offer. 
 Any Certificated Note delivered in
reliance upon this paragraph will not bear the Restricted Legend. 
 (d) The Trustee will retain copies of all certificates,
opinions and other documents received in connection with the transfer or exchange of a Note (or a beneficial interest therein), and the Company will have the right to inspect and make copies thereof at any reasonable time upon written notice to the
Trustee. 
 (e) The Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any
restrictions on transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in 

  
 17 

 
any Note (including any transfers between or among Depository participants or beneficial owners of interests in any Global Note) other than to require delivery of such certificates and other
documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof.

 Notwithstanding anything to the contrary herein, this Section 2.04 will become effective immediately after the authentication and
delivery of Global Notes evidencing $400,000,000 aggregate principal amount of the 2016 Notes, $750,000,000 aggregate principal amount of the 2018 Notes, $1,350,000,000 aggregate principal amount of the 2023 Notes and $1,150,000,000 aggregate
principal amount of the 2043 Notes. 
 Section 2.05. Temporary Offshore Global Notes. (a) Each Note originally
sold by the Initial Purchasers in reliance upon Regulation S will be evidenced by one or more Offshore Global Notes that bear the Temporary Offshore Global Note Legend. 
 (b) An owner of a beneficial interest in a Temporary Offshore Global Note (or a Person acting on behalf of such an owner) may provide to the Trustee (and the Trustee will accept) a duly completed
Certificate of Beneficial Ownership at any time after the Restricted Period (it being understood that the Trustee will not accept any such certificate during the Restricted Period). Promptly after acceptance of a Certificate of Beneficial Ownership
with respect to such a beneficial interest, the Trustee will cause such beneficial interest to be exchanged for an equivalent beneficial interest in a Permanent Offshore Global Note, and will (x) permanently reduce the principal amount of such
Temporary Offshore Global Note by the amount of such beneficial interest and (y) increase the principal amount of such Permanent Offshore Global Note by the amount of such beneficial interest. 

(c) Notwithstanding paragraph (b), if after the Restricted Period any Initial Purchaser owns a beneficial interest in a Temporary
Offshore Global Note, such Initial Purchaser may, upon written request to the Trustee accompanied by a certification as to its status as an Initial Purchaser, exchange such beneficial interest for an equivalent beneficial interest in a Permanent
Offshore Global Note, and the Trustee will comply with such request and will (x) permanently reduce the principal amount of such Temporary Offshore Global Note by the amount of such beneficial interest and (y) increase the principal amount
of such Permanent Offshore Global Note by the amount of such beneficial interest. 
 (d) Notwithstanding anything to the
contrary contained herein, any owner of a beneficial interest in a Temporary Offshore Global Note shall not be entitled to receive payment of principal or interest on such beneficial interest or

  
 18 

 
other amounts in respect of such beneficial interest until such beneficial interest is exchanged for an interest in a Permanent Offshore Global Note or transferred for an interest in another
Global Note or a Certificated Note. 
 Section 2.06. Terms of the Notes. The following terms relating to the Notes
are hereby established: 
 (a) Title. The 2016 Notes shall constitute a series of Securities having the title
“1.150% Senior Notes due 2016,” the 2018 Notes shall constitute a separate series of Securities having the title “1.1875% Senior Notes due 2018,” the 2023 Notes shall constitute a separate series of Securities having the title
“3.250% Senior Notes due 2023” and the 2043 Notes shall constitute a separate series of Securities having the title “4.700% Senior Notes due 2043.” 
 (b) Principal Amount. The aggregate principal amount of the 2016 Notes that may be initially authenticated and delivered under the Indenture (except for 2016 Notes authenticated and delivered upon
registration of, transfer of, or in exchange for, or in lieu of, other 2016 Notes pursuant to Sections 2.03, 2.06, 2.07, 3.07 or 10.06 of the Indenture) shall be $400,000,000. The aggregate principal amount of the 2018 Notes that may be initially
authenticated and delivered under the Indenture (except for 2018 Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu of, other 2018 Notes pursuant to Sections 2.03, 2.06, 2.07, 3.07 or 10.06 of the
Indenture) shall be $750,000,000. The aggregate principal amount of the 2023 Notes that may be initially authenticated and delivered under the Indenture (except for 2023 Notes authenticated and delivered upon registration of, transfer of, or in
exchange for, or in lieu of, other 2023 Notes pursuant to Sections 2.03, 2.06, 2.07, 3.07 or 10.06 of the Indenture) shall be $1,350,000,000. The aggregate principal amount of the 2043 Notes that may be initially authenticated and delivered under
the Indenture (except for 2043 Notes authenticated and delivered upon registration of, transfer of, or in exchange for, or in lieu of, other 2043 Notes pursuant to Sections 2.03, 2.06, 2.07, 3.07 or 10.06 of the Indenture) shall be $1,150,000,000.
The Company may from time to time, without the consent of the Holders of Notes of any series, issue additional Notes (in any such case “Additional Notes”) of any series having the same ranking and the same interest rate, maturity
and other terms as the Notes of that series, except for the issue date, the public offering price and, in some cases, the first Interest Payment Date. Any Additional Notes of a series and the existing Notes of that series will constitute a single
series under the Indenture and all references to the relevant Notes shall include the Additional Notes unless the context otherwise requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing;
provided further that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such
Notes. 

  
 19 

 (c) Maturity Date. The entire outstanding principal of the 2016 Notes shall be
payable on February 1, 2016, the entire outstanding principal of the 2018 Notes shall be payable on February 1, 2018, the entire outstanding principal of the 2023 Notes shall be payable on February 1, 2023 and the entire outstanding
principal of the 2043 Notes shall be payable on February 1, 2043. 
 (d) Interest Rate. The rate at which the 2016
Notes shall bear interest shall be 1.150% per annum, the rate at which the 2018 Notes shall bear interest shall be 1.875% per annum, the rate at which the 2023 Notes shall bear interest shall be 3.250% per annum and the rate at which
the 2043 Notes shall bear interest shall be 4.700% per annum; the date from which interest shall accrue on the Notes shall be January 28, 2013, or the most recent Interest Payment Date to which interest has been paid or provided for; the
Interest Payment Dates for the Notes shall be February 1 and August 1 of each year, beginning August 1, 2013; the interest so payable, and punctually paid or duly provided for, on any Interest Payment Date, will be paid, in
immediately available funds, to the Persons in whose names the Notes (or one or more predecessor securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the January 17 or July 17, as
the case may be, next preceding such Interest Payment Date. Payment of principal and interest on the Notes will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose,
in such currency of the United States of America as at the time of payment is legal tender for payment of public and private debts; provided, however, that each installment of interest and principal on the Notes may at the Company’s
option be paid in immediately available funds by transfer to an account maintained by the payee located in the United States of America. 
 (e) Currency. The currency of denomination of the Notes is United States Dollars. Payment of principal of and interest and premium, if any, on the Notes will be made in United States Dollars.

 Section 2.07. Optional Redemption. (a) The provisions of Article 3 of the Indenture shall apply to the
Notes. 
 (b) For the benefit of the Holders of the Notes, a new Section 3.08 shall be added to the Indenture as follows:

 “Section 3.08. Notice to Holders; Redemption Price; etc. 

(a) At any time and from time to time, the Notes of each series will be redeemable, as a whole or in part, at the
Company’s option, on at least 30 days, but not more than 60 days, prior notice mailed to the registered address of each holder of the Notes of the applicable series, or by the Trustee for transmission to the Depository or its nominee at the

  
 20 

 
written request and at the expense of the Company or such other notice method in accordance with the Indenture as determined by a resolution of the Board of Directors of the Company or a
certificate executed by certain Officers of the Company, at a redemption price equal to the greater of (i) 100% of principal amount of the Notes to be redeemed, and (ii) the sum of the present values of the remaining scheduled payments of
interest and principal thereon (not including the amount of accrued and unpaid interest to, but excluding, the date of redemption) discounted to the date of redemption on a semiannual basis, assuming a 360-day year consisting of twelve 30-day
months, at the Treasury Rate, as determined by the Reference Treasury Dealer, plus 15 basis points in the case of the 2016 Notes, 20 basis points in the case of the 2018 Notes, 25 basis points in the case of the 2023 Notes and 30 basis points
in the case of the 2043 Notes, plus, in the case of either (i) or (ii), accrued and unpaid interest to, but excluding, the date of redemption; provided that the principal amount of any Note remaining outstanding after a redemption
in part shall be $2,000 or a higher integral multiple of $1,000; provided further, however, that if the Company redeems the 2023 Notes 90 days or fewer prior to their Stated Maturity, the redemption price will equal 100% of the principal
amount of the 2023 Notes to be redeemed plus accrued and unpaid interest on the amount being redeemed to, but excluding, the date of redemption; provided further, however, that if the Company redeems the 2043 Notes 180 days or fewer prior to
their Stated Maturity, the redemption price will equal 100% of the principal amount of the 2043 Notes to be redeemed plus accrued and unpaid interest on the amount being redeemed to, but excluding, the date of redemption. 

(b) On and after the Redemption Date for the Notes of any series, interest will cease to accrue on the Notes of such
series or any portion thereof called for redemption, unless the Company defaults in the payment of the redemption price. By 10:00 a.m. New York City time on, or before, the Redemption Date for the Notes of such series, the Company will deposit with
a Paying Agent, or the Trustee, funds sufficient to pay the redemption price of and accrued and unpaid interest on the Notes to be redeemed on such date. If less than all of the Notes of a series are to be redeemed, the Notes of that series to be
redeemed will be selected by the Trustee in accordance with the procedures of DTC.” 
 (c) For the benefit of the Holders
of the Notes, a new Section 3.09 shall be added to the Indenture as follows: 
 “Section 3.09.
Repurchase of Notes Upon a Change of Control. 
 (a) If a Change of Control Triggering Event occurs with
respect to the Notes, unless the Company shall have exercised its option to 

  
 21 

 
redeem the Notes as described in Section 3.09 of this Indenture, the Company shall be required to make an offer (the “Change of Control Offer”) to each Holder to repurchase
all or any part (equal to $2,000 principal amount or a higher integral multiple of $1,000) of such Holder’s Notes on the terms set forth in this Section 3.09 and in the Notes. In the Change of Control Offer, the Company shall offer payment
in cash equal to 101% of the aggregate principal amount of Notes repurchased, plus accrued and unpaid interest, if any, on the Notes repurchased to but excluding the date of repurchase (the “Change of Control Payment”). With
respect to the Notes of each series, within 30 days following any Change of Control Triggering Event the Company shall mail a notice to Holders of Notes of the applicable series, with a copy to the Trustee, describing the transaction or transactions
that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date such notice is
mailed (the “Change of Control Payment Date”). 
 (b) On the Change of Control Payment Date, the
Company shall, to the extent lawful: 
 (1) accept for payment all Notes or portions of Notes properly tendered
pursuant to the Change of Control Offer; 
 (2) deposit with the Paying Agent an amount equal to the Change of
Control Payment in respect of all Notes or portions of Notes properly tendered; and 
 (3) deliver or cause to be
delivered to the Trustee the Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes or portions of Notes being repurchased. 

(c) The Company shall not be required to make a Change of Control Offer upon the occurrence of a Change of Control
Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases all Notes properly tendered and not withdrawn under
its offer. 
 (d) The Company shall comply in all material respects with the requirements of Rule 14e-1 under the
Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that the

  
 22 

 
provisions of any such securities laws or regulations conflict with this Section 3.09, the Company shall comply with the applicable securities laws and regulations and shall not be deemed to
have breached its obligations under this Section 3.09 by virtue of any such conflict.” 
 Section 2.08.
Special Mandatory Redemption. A new Section 3.10 shall be added to the Indenture as follows: 
 “Section 3.10.
Special Mandatory Redemption. 
 (a) If, for any reason, the initial public offering of the Company’s
Class A common stock pursuant to an effective registration statement filed with the Commission pursuant to the Securities Act is not completed on or prior to August 31, 2013, or if on an earlier date Pfizer notifies the Company that it has
determined, in its sole discretion, that such initial public offering will not be consummated (each, a “Special Mandatory Redemption Trigger Date”), the Notes shall become due and payable on the Special Mandatory Redemption Date at
the Special Mandatory Redemption Price. 
 (b) Notice of a special mandatory redemption will be mailed, with a
copy to the Trustee, promptly after the occurrence of the event triggering such redemption to each Holder of Notes at its registered address. If funds sufficient to pay the Special Mandatory Redemption Price of all of the Notes to be redeemed on the
Special Mandatory Redemption Date are deposited with the Paying Agent on or before such Special Mandatory Redemption Date, on and after such Special Mandatory Redemption Date, the Notes will cease to bear interest and, other than the right to
receive the Special Mandatory Redemption Price, all rights under the Notes shall terminate.” 
 Section 2.09.
Limitation on Liens. For the benefit of the Holders of the Notes, a new Section 5.06 shall be added to the Indenture as follows: 
 “The Company shall not, and shall not permit any Restricted Subsidiary of the Company to, create, assume or suffer to exist any Lien (an “Initial Lien”), other than Permitted Liens,
on any Principal Property to secure any Debt of the Company or any Restricted Subsidiary unless it has made or will make effective provision whereby the Notes and any other debt securities of any series issued pursuant to the Indenture and having
the benefit of this Section 5.06 will be secured by such Lien equally and ratably with (or prior to) all other Debt secured by such Lien. Any Lien created for the benefit of the Holders of the Notes and any other debt securities of any series
issued pursuant to this Indenture and having the benefit of this Section 5.06 shall provide by its terms that such Lien 

  
 23 

 
will be automatically released and discharged upon the release and discharge of the applicable Initial Lien.” 
 Section 2.10. Limitation on Sale and Leaseback Transactions. For the benefit of the Holders of the Notes, a new Section 5.07 shall be added to the Indenture as follows: 

“The Company shall not, and shall not permit any Restricted Subsidiary to, enter into any Sale and Leaseback
Transaction covering any Principal Property, unless (i) pursuant to Section 5.06 of this Indenture, the Company or the Restricted Subsidiary would be entitled to incur Debt secured by a Lien on such Principal Property in a principal amount
equal to the Value of such Sale and Leaseback Transaction without equally and ratably securing the Notes and any other debt securities of any series issued pursuant to the Indenture and having the benefit of this Section 5.07; or (ii) the
Company or any Restricted Subsidiary, during the 270 days following the effective date of the Sale and Leaseback Transaction, applies an amount equal to the Value of such Sale and Leaseback Transaction to the voluntary retirement of long-term Debt
of the Company or any Restricted Subsidiary or to the acquisition of one or more Principal Properties.” 
 ARTICLE 3

 MISCELLANEOUS 
 Section 3.01. Trust Indenture Act Controls. If any provision of this First Supplemental Indenture limits, qualifies or conflicts with another provision which is required to be included in this
First Supplemental Indenture by the Trust Indenture Act, the required provision shall control. If any provision of this First Supplemental Indenture modifies or excludes any provision of the Trust Indenture Act which may be so modified or excluded,
the latter provision shall be deemed to apply to this First Supplemental Indenture as so modified or to be excluded, as the case may be. 
 Section 3.02. Governing Law. This First Supplemental Indenture and the Notes shall be governed by and construed in accordance with the laws of the State of New York, without giving effect to
any choice of law or conflict of law provision or rule that would cause the application of the laws of any other jurisdiction. 

Section 3.03. Multiple Counterparts. The parties may sign multiple counterparts of this First Supplemental Indenture. Each
signed counterpart shall be deemed an original, but all of them together represent one and the same First Supplemental Indenture. 

  
 24 

 Section 3.04. Severability. Each provision of this First Supplemental Indenture
shall be considered separable and if for any reason any provision which is not essential to the effectuation of the basic purpose of this First Supplemental Indenture or the Notes shall be invalid, illegal or unenforceable, the validity, legality
and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and a Holder shall have no claim therefor against any party hereto. 
 Section 3.05. Relation to Indenture. This First Supplemental Indenture constitutes a part of the Indenture, the provisions of which (as modified by this First Supplemental Indenture) shall
apply to the series of Securities established by this First Supplemental Indenture but shall not modify, amend or otherwise affect the Indenture insofar as it relates to any other series of Securities or modify, amend or otherwise affect in any
manner the terms and conditions of the Securities of any other series. 
 Section 3.06. Ratification. The Indenture,
as supplemented and amended by this First Supplemental Indenture, is in all respects ratified and confirmed. The Indenture and this First Supplemental Indenture shall be read, taken and construed as one and the same instrument. All provisions
included in this First Supplemental Indenture supersede any conflicting provisions included in the Indenture unless not permitted by law. The Trustee accepts the trusts created by the Indenture, as supplemented by this First Supplemental Indenture,
and agrees to perform the same upon the terms and conditions of the Indenture, as supplemented by this First Supplemental Indenture. 
 Section 3.07. Effectiveness. The provisions of this First Supplemental Indenture shall become effective as of the date hereof. 

Section 3.08. Trustee Not Responsible for Recitals or Issuance of Securities. The recitals contained herein and in the
Securities, except the Trustee’s certificates of authentication, shall be taken as the statements of the Company, and the Trustee or any Authenticating Agent assumes no responsibility for their correctness. The Trustee makes no representations
as to the validity or sufficiency of this First Supplemental Indenture or of the Securities. The Trustee or any Authenticating Agent shall not be accountable for the use or application by the Company of Securities or the proceeds thereof. In the
performance of its obligations hereunder, the Trustee shall be provided with all rights, benefits, protections, indemnities and immunities afforded to it pursuant to the Base Indenture. 

[Remainder of this page intentionally left blank] 

  
 25 

 IN WITNESS WHEREOF, the parties hereto have caused this First Supplemental Indenture to be
duly executed as of the date first above written. 
  

					
	ZOETIS INC.,
	      as the Company
		
	By:	 	 /s/ Heidi C. Chen

		 	Name:	 	Heidi C. Chen
		 	Title:	 	Executive Vice President, General Counsel and Corporate Secretary

 [Signature Page to First Supplemental Indenture] 

					
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	 /s/ Rodney Gaughan

		 	Name:	 	Rodney Gaughan
		 	Title:	 	Vice President
		
	By:	 	 /s/ Linda Reale

		 	Name:	 	Linda Reale
		 	Title:	 	Vice President

 [Signature Page to First Supplemental Indenture] 

 EXHIBIT A 
 Form of 1.150% Senior Note due 2016 
 ZOETIS INC. 

1.150% Senior Note due 2016 
 PRINCIPAL AMOUNT 

					
	No.	 		 	$[            ]               
       

 [144A] CUSIP: 
 [144A] ISIN: 
 [Reg. S] CUSIP: 

[Reg. S] ISIN: 
 Zoetis
Inc., a Delaware corporation (herein called the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to [Include in Global Note: Cede &
Co.;], or registered assigns, the principal sum [Include in Global Note: of $[        ]] [Include in Global Note: set forth in the attached Schedule of Increases and Decreases in Global Note] on
February 1, 2016 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from January 28, 2013 (the “Original Issue Date”) or from the most
recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 1.150% per annum, on February 1 and August 1 (each such date, an “Interest Payment Date”), commencing
August 1, 2013, until the principal hereof is paid or made available for payment. 
 Payment of Interest. The
interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York Time, on any Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose
name this Note (or one or more predecessor securities) is registered at the close of business on the January 17 or July 17 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest
Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such
Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such
Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of
any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 
 Time of Payment. In any case where any Interest Payment Date, the
Maturity Date or any date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date,
but may be made on the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay.

 General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or
more series under an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor
Trustee under the Indenture with respect to a series of which this Note is a part), as supplemented by a First Supplemental Indenture thereto, dated as of January 28, 2013 (the “First Supplemental Indenture” and, together with
the Base Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “1.150% Senior Notes due
2016” (collectively, the “Notes”), initially limited in aggregate principal amount to $400,000,000. 

Further Issuance. The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities
(the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the
Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further
that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 

Events of Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the
Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 
 Sinking Fund. The
Notes are not subject to any sinking fund. 

 Special Mandatory Redemption. If, for any reason, the initial public offering of the
Company’s Class A common stock pursuant to an effective registration statement filed with the Commission pursuant to the Securities Act is not completed on or prior to August 31, 2013, or if on an earlier date Pfizer notifies the
Company that it has determined, in its sole discretion, that the initial public offering will not be consummated, the Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

Optional Redemption. The Notes will be redeemable at any time, at the option of the Company, in whole or from time to time in
part, upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon, if any, to, but excluding, the Redemption
Date. In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part only, the notice of redemption relating to such Note shall
state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000. A new Note in principal
amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note. 

Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to
the Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 

Restrictive Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its
Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive
covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the Company, and the Trustee with the consent of the Holders of not less than a majority in
aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less than a majority in aggregate principal amount of the Securities at the time outstanding,
on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in the Indenture permit the Holders of not less than a majority in aggregate principal
amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults under the Indenture and their consequences. Any such consent or waiver shall be
conclusive and binding upon the Holder of this Note and upon all 

 
future Holders of this Note and of any Note issued upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon
this Note. 
 No reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the currency, herein prescribed. 

No Recourse Against Others. No director, officer, agent, employee, incorporator, stockholder, partner, member, or manager of the
Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of the Notes by accepting a Note waives
and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no Holder of any Note will have any right
to institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect to this series, the Holders of not
less than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the Trustee shall not have received from the
Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that such limitations do not apply to a suit
instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 
 Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Registration of Transfer or Exchange. As provided in the Indenture and subject to certain limitations herein and therein set
forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the Company in any place where the principal of
and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder hereof or his attorney duly authorized in
writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like
aggregate principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 

 No service charge shall be made for any such registration of transfer or exchange, but the
Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to
the contrary. 
 [Include in any Restricted Note: 
 Additional Rights of Holders of Restricted Global Notes and Restricted Certificated Notes. Pursuant to, but subject to the exceptions in, the Registration Rights Agreement dated as of
January 28, 2013 (as amended, supplemented or otherwise modified, the “Registration Rights Agreement”) among the Company and the Representatives of the Initial Purchasers party thereto with respect to the Notes, the Company
will be obligated to consummate an exchange offer pursuant to which the Holder of this Note shall have the right to exchange this Note for a like principal amount of debt securities of the Company which shall have been registered under the
Securities Act having terms identical in all material respects to this Note (except for the transfer restrictions relating to this Note and except that such note shall not be entitled to Additional Interest (as defined in the Registration Rights
Agreement)). The Holders shall be entitled to receive certain Additional Interest (as defined in the Registration Rights Agreement) in the event such exchange offer is not consummated or the Notes are not offered for resale and upon certain other
conditions, all pursuant to the terms of the Registration Rights Agreement.] 
 Defined Terms. All terms used in this
Note, which are defined in the Indenture and are not otherwise defined herein, shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by and construed in accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by the Trustee by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed and its seal
to be hereunto affixed and attested. 
 Dated: 

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	Attest:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned First Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	  

		 	Name:
		 	Title:

 Dated: 

 ASSIGNMENT FORM 
 I or we assign and transfer this Note to 
  
  

 
  

 
 (Print or type name, address and zip code of
assignee or transferee) 
  
  

 
 (Insert Social Security or other identifying number
of assignee or transferee) 
 and irrevocably appoint
                                        
agent to transfer this Note on the books of the Company. The agent may substitute another to act for him. 
  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

 [Include in any Restricted Securities: Transfer Certification for Restricted Securities: 

In connection with any transfer of this Note occurring prior to the date following the first anniversary of the original issuance of this
Note, the undersigned confirms that it has not utilized any general solicitation or general advertising in connection with the transfer: 
 [Check One] 
  

					
	(1)	 	              
	  	to the Company or a subsidiary thereof; or
			
	(2)	 	  
	  	pursuant to and in compliance with Rule 144A under the Securities Act; or
			
	(3)	 	  
	  	outside the United States in compliance with Regulation S under the Securities Act; or
			
	(4)	 	  
	  	pursuant to the exemption from registration provided by Rule 144 under the Securities Act; or
			
	(5)	 	  
	  	pursuant to an effective registration statement under the Securities Act; or
			
	(6)	 	  
	  	pursuant to another available exemption from the registration statement requirements of the Securities Act.

 Unless one of the items is checked, the Trustee will refuse to register any of the Notes
evidenced by this certificate in the name of any person other than the registered Holder thereof; provided, however, that if item (3), (4) or (6) is checked, the Company or the Trustee may require, prior to registering any such
transfer of the Notes, in their sole discretion, such written legal opinions, certifications) and other information as the Company or the Trustee has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or
in a transaction not subject to, the registration requirements of the Securities Act. 
 If none of the foregoing items are
checked, the Trustee or Registrar shall not be obligated to register this Note in the name of any person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein shall have been satisfied.

  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)]

 Rule 144A Certificate 
 TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED 
 The undersigned
represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the
meaning of Rule 144A under the Securities Act and is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A
or has determined not to request such information and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 

 

									
	Dated:	 	  
	 		 		 	  

		 		 		 		 	NOTICE: To be executed by an executive officer

 Regulation S Certificate 
 TO BE COMPLETED BY TRANSFEROR IF (3) ABOVE IS CHECKED 
 Terms are used in below are as used
in Regulation S (“Regulation S”) under the Securities Act of 1933, as amended (the “Securities Act”), except as otherwise stated herein. 
 The undersigned represents and warrants: 
  

	1.	The offer and sale of the Notes was not and will not be made to a person in the United States (unless such person is excluded from the definition of “U.S.
person” pursuant to Rule 902(k)(2)(vi) or the account held by it for which it is acting is excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3)) and such offer
and sale was not and will not be specifically targeted at an identifiable group of U.S. citizens abroad. 

  

	2.	Unless the circumstances described in the parenthetical in paragraph 1 above are applicable, either (a) at the time the buy order was originated, the buyer was
outside the United States or the undersigned and any person acting on our behalf reasonably believed that the buyer was outside the United States or (b) the transaction was executed in, on or through the facilities of a designated offshore
securities market, and neither the undersigned nor any person acting on behalf of the undersigned knows that the transaction was pre-arranged with a buyer in the United States. 

 

	3.	Neither the undersigned, any affiliate of the undersigned, nor any person acting on behalf of the undersigned or its affiliates has made any directed selling efforts in
the United States with respect to the Notes. 

  

	4.	The proposed transfer of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

			
	Dated:	 	  

 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 
 Zoetis Inc. 
 1.150% Senior Note due 2016 

The initial principal amount of this Global Note is $[        ]. The following increases or
decreases in this Global Note have been made: 
  

									
	 Date
	  	Amount of decrease
in Principal Amount
of this Global Note	  	Amount of increase
in Principal Amount
of this Global Note	  	Principal Amount of
this Global Note
following such
decrease or increase	  	 Signature of
authorized signatory
of Trustee or
Note
Custodian

		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

 EXHIBIT B 
 Form of 1.875% Senior Note due 2018 
 ZOETIS INC. 

1.875% Senior Note due 2018 
 PRINCIPAL AMOUNT 

					
	No.	 		 	$[            ]               
       

 [144A] CUSIP: 
 [144A] ISIN: 
 [Reg. S] CUSIP: 

[Reg. S] ISIN: 
 Zoetis
Inc., a Delaware corporation (herein called the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to [Include in Global Note: Cede &
Co.;], or registered assigns, the principal sum [Include in Certificated Note: of $[        ]] [Include in Global Note: set forth in the attached Schedule of Increases and Decreases in Global Note] on
February 1, 2018 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from January 28, 2013 (the “Original Issue Date”) or from the most
recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 1.875% per annum, on February 1 and August 1 (each such date, an “Interest Payment Date”), commencing
August 1, 2013, until the principal hereof is paid or made available for payment. 
 Payment of Interest. The
interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York Time, on any Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose
name this Note (or one or more predecessor securities) is registered at the close of business on the January 17 or July 17 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest
Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such
Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such
Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of
any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 
 Time of Payment. In any case where any Interest Payment Date, the
Maturity Date or any date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date,
but may be made on the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay.

 General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or
more series under an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor
Trustee under the Indenture with respect to a series of which this Note is a part), as supplemented by a First Supplemental Indenture thereto, dated as of January 28, 2013 (the “First Supplemental Indenture” and, together with
the Base Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “1.875% Senior Notes due
2018” (collectively, the “Notes”), initially limited in aggregate principal amount to $750,000,000. 

Further Issuance. The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities
(the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the
Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further
that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 

Events of Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the
Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 
 Sinking Fund. The
Notes are not subject to any sinking fund. 

 Special Mandatory Redemption. If, for any reason, the initial public offering of the
Company’s Class A common stock pursuant to an effective registration statement filed with the Commission pursuant to the Securities Act is not completed on or prior to August 31, 2013, or if on an earlier date Pfizer notifies the
Company that it has determined, in its sole discretion, that the initial public offering will not be consummated, the Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

Optional Redemption. The Notes will be redeemable at any time, at the option of the Company, in whole or from time to time in
part, upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon, if any, to, but excluding, the Redemption
Date. In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part only, the notice of redemption relating to such Note shall
state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000. A new Note in principal
amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note. 

Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to
the Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 

Restrictive Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its
Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive
covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the Company, and the Trustee with the consent of the Holders of not less than a majority in
aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less than a majority in aggregate principal amount of the Securities at the time outstanding,
on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in the Indenture permit the Holders of not less than a majority in aggregate principal
amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults under the Indenture and their consequences. Any such consent or waiver shall be
conclusive and binding upon the Holder of this Note and upon all 

 
future Holders of this Note and of any Note issued upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon
this Note. 
 No reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the currency, herein prescribed. 

No Recourse Against Others. No director, officer, agent, employee, incorporator, stockholder, partner, member, or manager of the
Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of the Notes by accepting a Note waives
and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no Holder of any Note will have any right
to institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect to this series, the Holders of not
less than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the Trustee shall not have received from the
Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that such limitations do not apply to a suit
instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 
 Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Registration of Transfer or Exchange. As provided in the Indenture and subject to certain limitations herein and therein set
forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the Company in any place where the principal of
and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder hereof or his attorney duly authorized in
writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like
aggregate principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 

 No service charge shall be made for any such registration of transfer or exchange, but the
Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to
the contrary. 
 [Include in any Restricted Note: 
 Additional Rights of Holders of Restricted Global Notes and Restricted Certificated Notes. Pursuant to, but subject to the exceptions in, the Registration Rights Agreement dated as of
January 28, 2013 (as amended, supplemented or otherwise modified, the “Registration Rights Agreement”) among the Company and the Representatives of the Initial Purchasers party thereto with respect to the Notes, the Company
will be obligated to consummate an exchange offer pursuant to which the Holder of this Note shall have the right to exchange this Note for a like principal amount of debt securities of the Company which shall have been registered under the
Securities Act having terms identical in all material respects to this Note (except for the transfer restrictions relating to this Note and except that such note shall not be entitled to Additional Interest (as defined in the Registration Rights
Agreement)). The Holders shall be entitled to receive certain Additional Interest (as defined in the Registration Rights Agreement) in the event such exchange offer is not consummated or the Notes are not offered for resale and upon certain other
conditions, all pursuant to the terms of the Registration Rights Agreement.] 
 Defined Terms. All terms used in this
Note, which are defined in the Indenture and are not otherwise defined herein, shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by and construed in accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by the Trustee by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed and its seal
to be hereunto affixed and attested. 
 Dated: 

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

		 	Name:
		 	Title:

 Attest: 
  

			
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned First Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	  

		 	Name:
		 	Title:

 Dated: 

 ASSIGNMENT FORM 
 I or we assign and transfer this Note to 
  
  

 
  

 
 (Print or type name, address and zip code of
assignee or transferee) 
  
  

 
 (Insert Social Security or other identifying number
of assignee or transferee) 
 and irrevocably appoint
                             agent to transfer this Note on the books of the Company. The agent may
substitute another to act for him. 
  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

 [Include in any Restricted Securities: Transfer Certification for Restricted Securities: 

In connection with any transfer of this Note occurring prior to the date following the first anniversary of the original issuance of this
Note, the undersigned confirms that it has not utilized any general solicitation or general advertising in connection with the transfer: 
 [Check One] 
  

					
	 (1)
	 	              
	  	to the Company or a subsidiary thereof; or
			
	 (2)
	 	  
	  	pursuant to and in compliance with Rule 144A under the Securities Act; or
			
	 (3)
	 	  
	  	outside the United States in compliance with Regulation S under the Securities Act; or
			
	 (4)
	 	  
	  	pursuant to the exemption from registration provided by Rule 144 under the Securities Act; or
			
	 (5)
	 	  
	  	pursuant to an effective registration statement under the Securities Act; or
			
	 (6)
	 	  
	  	pursuant to another available exemption from the registration statement requirements of the Securities Act.

 Unless one of the items is checked, the Trustee will refuse to register any of the Notes
evidenced by this certificate in the name of any person other than the registered Holder thereof; provided, however, that if item (3), (4) or (6) is checked, the Company or the Trustee may require, prior to registering any such
transfer of the Notes, in their sole discretion, such written legal opinions, certifications) and other information as the Company or the Trustee has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or
in a transaction not subject to, the registration requirements of the Securities Act. 
 If none of the foregoing items are
checked, the Trustee or Registrar shall not be obligated to register this Note in the name of any person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein shall have been satisfied.

  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)]

 Rule 144A Certificate 
 TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED 
 The undersigned
represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the
meaning of Rule 144A under the Securities Act and is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A
or has determined not to request such information and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 

 

									
	Dated:	 	  
	 		 		 	  

		 		 		 		 	NOTICE: To be executed by an executive officer

 Regulation S Certificate 
 TO BE COMPLETED BY TRANSFEROR IF (3) ABOVE IS CHECKED 
 Terms are used in below are as used
in Regulation S (“Regulation S”) under the Securities Act of 1933, as amended (the “Securities Act”), except as otherwise stated herein. 
 The undersigned represents and warrants: 
  

	1.	The offer and sale of the Notes was not and will not be made to a person in the United States (unless such person is excluded from the definition of “U.S.
person” pursuant to Rule 902(k)(2)(vi) or the account held by it for which it is acting is excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3)) and such offer
and sale was not and will not be specifically targeted at an identifiable group of U.S. citizens abroad. 

  

	2.	Unless the circumstances described in the parenthetical in paragraph 1 above are applicable, either (a) at the time the buy order was originated, the buyer was
outside the United States or the undersigned and any person acting on our behalf reasonably believed that the buyer was outside the United States or (b) the transaction was executed in, on or through the facilities of a designated offshore
securities market, and neither the undersigned nor any person acting on behalf of the undersigned knows that the transaction was pre-arranged with a buyer in the United States. 

 

	3.	Neither the undersigned, any affiliate of the undersigned, nor any person acting on behalf of the undersigned or its affiliates has made any directed selling efforts in
the United States with respect to the Notes. 

  

	4.	The proposed transfer of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

			
		
	Dated:	 	 

 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 
 Zoetis Inc. 
 1.875% Senior Note due 2018 

The initial principal amount of this Global Note is $[        ]. The following increases or
decreases in this Global Note have been made: 
  

									
	 Date
	  	Amount of decrease
in Principal Amount
of this Global Note	  	Amount of increase
in Principal Amount
of this Global Note	  	Principal Amount of
this Global Note
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee or
Note
Custodian
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

 EXHIBIT C 
 Form of 3.250% Senior Note due 2023 
 ZOETIS INC. 

3.250% Senior Note due 2023 
  

			
	No.	 	 PRINCIPAL AMOUNT

  $[            ]

 [144A] CUSIP: 
 [144A] ISIN: 
 [Reg. S] CUSIP: 

[Reg. S] ISIN: 
 Zoetis
Inc., a Delaware corporation (herein called the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to [Include in Global Note: Cede &
Co.;], or registered assigns, the principal sum [Include in Certificated Note: of $[        ]] [Include in Global Note: set forth in the attached Schedule of Increases and Decreases in Global Note] on
February 1, 2023 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from January 28, 2013 (the “Original Issue Date”) or from the most
recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 3.250% per annum, on February 1 and August 1 (each such date, an “Interest Payment Date”), commencing
August 1, 2013, until the principal hereof is paid or made available for payment. 
 Payment of Interest. The
interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York Time, on any Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose
name this Note (or one or more predecessor securities) is registered at the close of business on the January 17 or July 17 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest
Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such
Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such
Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of
any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 
 Time of Payment. In any case where any Interest Payment Date, the
Maturity Date or any date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date,
but may be made on the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay.

 General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or
more series under an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor
Trustee under the Indenture with respect to a series of which this Note is a part), as supplemented by a First Supplemental Indenture thereto, dated as of January 28, 2013 (the “First Supplemental Indenture” and, together with
the Base Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “3.250% Senior Notes due
2023” (collectively, the “Notes”), initially limited in aggregate principal amount to $1,350,000,000. 

Further Issuance. The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities
(the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the
Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further
that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 

Events of Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the
Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 
 Sinking Fund. The
Notes are not subject to any sinking fund. 

 Special Mandatory Redemption. If, for any reason, the initial public offering of the
Company’s Class A common stock pursuant to an effective registration statement filed with the Commission pursuant to the Securities Act is not completed on or prior to August 31, 2013, or if on an earlier date Pfizer notifies the
Company that it has determined, in its sole discretion, that the initial public offering will not be consummated, the Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

Optional Redemption. The Notes will be redeemable at any time, at the option of the Company, in whole or from time to time in
part, upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon, if any, to, but excluding, the Redemption
Date. In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part only, the notice of redemption relating to such Note shall
state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000. A new Note in principal
amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note. 

Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to
the Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 

Restrictive Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its
Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive
covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the Company, and the Trustee with the consent of the Holders of not less than a majority in
aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less than a majority in aggregate principal amount of the Securities at the time outstanding,
on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in the Indenture permit the Holders of not less than a majority in aggregate principal
amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults under the Indenture and their consequences. Any such consent or waiver shall be
conclusive and binding upon the Holder of this Note and upon all 

 
future Holders of this Note and of any Note issued upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon
this Note. 
 No reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the currency, herein prescribed. 

No Recourse Against Others. No director, officer, agent, employee, incorporator, stockholder, partner, member, or manager of the
Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of the Notes by accepting a Note waives
and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no Holder of any Note will have any right
to institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect to this series, the Holders of not
less than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the Trustee shall not have received from the
Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that such limitations do not apply to a suit
instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 
 Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Registration of Transfer or Exchange. As provided in the Indenture and subject to certain limitations herein and therein set
forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the Company in any place where the principal of
and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder hereof or his attorney duly authorized in
writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like
aggregate principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 

 No service charge shall be made for any such registration of transfer or exchange, but the
Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to
the contrary. 
 [Include in any Restricted Note: 
 Additional Rights of Holders of Restricted Global Notes and Restricted Certificated Notes. Pursuant to, but subject to the exceptions in, the Registration Rights Agreement dated as of
January 28, 2013 (as amended, supplemented or otherwise modified, the “Registration Rights Agreement”) among the Company and the Representatives of the Initial Purchasers party thereto with respect to the Notes, the Company
will be obligated to consummate an exchange offer pursuant to which the Holder of this Note shall have the right to exchange this Note for a like principal amount of debt securities of the Company which shall have been registered under the
Securities Act having terms identical in all material respects to this Note (except for the transfer restrictions relating to this Note and except that such note shall not be entitled to Additional Interest (as defined in the Registration Rights
Agreement)). The Holders shall be entitled to receive certain Additional Interest (as defined in the Registration Rights Agreement) in the event such exchange offer is not consummated or the Notes are not offered for resale and upon certain other
conditions, all pursuant to the terms of the Registration Rights Agreement.] 
 Defined Terms. All terms used in this
Note, which are defined in the Indenture and are not otherwise defined herein, shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by and construed in accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by the Trustee by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed and its seal
to be hereunto affixed and attested. 
 Dated: 

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	Attest:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned First Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	By:	 	  

		 	Name:
		 	Title:

 Dated: 

 ASSIGNMENT FORM 
 I or we assign and transfer this Note to 
  

 
  

 
 (Print or type name, address and zip code of
assignee or transferee) 
  
  

 
 (Insert Social Security or other identifying number
of assignee or transferee) 
 and irrevocably appoint
                                         
                                        agent to
transfer this Note on the books of the Company. The agent may substitute another to act for him. 
  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

 [Include in any Restricted Securities: Transfer Certification for Restricted Securities: 

In connection with any transfer of this Note occurring prior to the date following the first anniversary of the original issuance of this
Note, the undersigned confirms that it has not utilized any general solicitation or general advertising in connection with the transfer: 
 [Check One] 
  

					
			
	 (1)
	 	              
	  	to the Company or a subsidiary thereof; or
			
	 (2)
	 	              
	  	pursuant to and in compliance with Rule 144A under the Securities Act; or
			
	 (3)
	 	              
	  	outside the United States in compliance with Regulation S under the Securities Act; or
			
	 (4)
	 	              
	  	pursuant to the exemption from registration provided by Rule 144 under the Securities Act; or
			
	 (5)
	 	              
	  	pursuant to an effective registration statement under the Securities Act; or
			
	 (6)
	 	              
	  	pursuant to another available exemption from the registration statement requirements of the Securities Act.

 Unless one of the items is checked, the Trustee will refuse to register any of the Notes
evidenced by this certificate in the name of any person other than the registered Holder thereof; provided, however, that if item (3), (4) or (6) is checked, the Company or the Trustee may require, prior to registering any such
transfer of the Notes, in their sole discretion, such written legal opinions, certifications) and other information as the Company or the Trustee has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or
in a transaction not subject to, the registration requirements of the Securities Act. 
 If none of the foregoing items are
checked, the Trustee or Registrar shall not be obligated to register this Note in the name of any person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein shall have been satisfied.

  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)]

 Rule 144A Certificate 
 TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED 
 The undersigned
represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the
meaning of Rule 144A under the Securities Act and is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A
or has determined not to request such information and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 

 

							
	Dated:	 	  
	 		  	  

		 		 		  	NOTICE: To be executed by an executive officer

 Regulation S Certificate 
 TO BE COMPLETED BY TRANSFEROR IF (3) ABOVE IS CHECKED 
 Terms are used in below are as used
in Regulation S (“Regulation S”) under the Securities Act of 1933, as amended (the “Securities Act”), except as otherwise stated herein. 
 The undersigned represents and warrants: 
  

	1.	The offer and sale of the Notes was not and will not be made to a person in the United States (unless such person is excluded from the definition of “U.S.
person” pursuant to Rule 902(k)(2)(vi) or the account held by it for which it is acting is excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3)) and such offer
and sale was not and will not be specifically targeted at an identifiable group of U.S. citizens abroad. 

  

	2.	Unless the circumstances described in the parenthetical in paragraph 1 above are applicable, either (a) at the time the buy order was originated, the buyer was
outside the United States or the undersigned and any person acting on our behalf reasonably believed that the buyer was outside the United States or (b) the transaction was executed in, on or through the facilities of a designated offshore
securities market, and neither the undersigned nor any person acting on behalf of the undersigned knows that the transaction was pre-arranged with a buyer in the United States. 

 

	3.	Neither the undersigned, any affiliate of the undersigned, nor any person acting on behalf of the undersigned or its affiliates has made any directed selling efforts in
the United States with respect to the Notes. 

  

	4.	The proposed transfer of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

			
	Dated:	 	  

 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 
 Zoetis Inc. 
 3.250% Senior Note due 2023 

The initial principal amount of this Global Note is $[        ]. The following increases or
decreases in this Global Note have been made: 
  

									
	 Date
	  	Amount of decrease
in Principal Amount
of this Global Note	  	Amount of increase
in Principal Amount
of this Global Note	  	Principal Amount of
this Global Note
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee or Note
Custodian
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

 EXHIBIT D 
 Form of 4.700% Senior Note due 2043 
 ZOETIS INC. 

4.700% Senior Note due 2043 
  

			
	No.	 	 PRINCIPAL AMOUNT

  $[            ]

 [144A] CUSIP: 
 [144A] ISIN: 
 [Reg. S] CUSIP: 

[Reg. S] ISIN: 
 Zoetis
Inc., a Delaware corporation (herein called the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to [Include in Global Note: Cede &
Co.;], or registered assigns, the principal sum [Include in Certificated Note: of $[        ]] [Include in Global Note: set forth in the attached Schedule of Increases and Decreases in Global Note] on
February 1, 2043 (the “Maturity Date”) (except to the extent redeemed or repaid prior to the Maturity Date) and to pay interest thereon from January 28, 2013 (the “Original Issue Date”) or from the most
recent Interest Payment Date to which interest has been paid or duly provided for semi-annually at the rate of 4.700% per annum, on February 1 and August 1 (each such date, an “Interest Payment Date”), commencing
August 1, 2013, until the principal hereof is paid or made available for payment. 
 Payment of Interest. The
interest so payable, and punctually paid or made available for payment, by 10:00 a.m. New York Time, on any Interest Payment Date, will, as provided in the Indenture (defined below), be paid, in immediately available funds, to the Person in whose
name this Note (or one or more predecessor securities) is registered at the close of business on the January 17 or July 17 (whether or not a Business Day, as defined in the Indenture), as the case may be, next preceding such Interest
Payment Date (the “Regular Record Date”). Any such interest not punctually paid or duly provided for (“Defaulted Interest”) will forthwith cease to be payable to the Holder on such Regular Record Date, and such
Defaulted Interest, may be paid to the Person in whose name this Note (or one or more predecessor securities) is registered at the close of business on a special record date (the “Special Record Date”) for the payment of such
Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Notes not less than ten days prior to such Special Record Date, or may be paid at any time in any other lawful manner not inconsistent with requirements of
any securities exchange on which the Notes may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

 Place of Payment. Payment of principal, premium, if any, and interest on this Note
will be made at the Corporate Trust Office of the Trustee or such other office or agency of the Company as may be designated for such purpose, in such currency of the United States of America as at the time of payment is legal tender for payment of
public and private debts; provided, however, that each installment of interest, premium, if any, and principal on this Note may at the Company’s option be paid in immediately available funds by transfer to an account maintained by the
payee located in the United States of America. 
 Time of Payment. In any case where any Interest Payment Date, the
Maturity Date or any date fixed for redemption or repayment of the Notes shall not be a Business Day, then (notwithstanding any other provision of the Indenture or this Note), payment of principal or interest, if any, need not be made on such date,
but may be made on the next succeeding Business Day with the same force and effect as if made on such Interest Payment Date, the Maturity Date or the date so fixed for redemption or repayment, and no interest shall accrue in respect of the delay.

 General. This Note is one of a duly authorized issue of Securities of the Company, issued and to be issued in one or
more series under an indenture (the “Base Indenture”), dated as of January 28, 2013, between the Company and Deutsche Bank Trust Company Americas (herein called the “Trustee,” which term includes any successor
Trustee under the Indenture with respect to a series of which this Note is a part), as supplemented by a First Supplemental Indenture thereto, dated as of January 28, 2013 (the “First Supplemental Indenture” and, together with
the Base Indenture, the “Indenture”), among the Company and the Trustee. Reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the
Trustee and the Holders of the Securities, and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Note is one of a duly authorized series of Securities designated as “4.700% Senior Notes due
2043” (collectively, the “Notes”), initially limited in aggregate principal amount to $1,150,000,000. 

Further Issuance. The Company may from time to time, without the consent of the Holders of the Notes, issue additional Securities
(the “Additional Securities”) of this series having the same ranking and the same interest rate, maturity and other terms as the Notes. Any Additional Securities of this series and the Notes will constitute a single series under the
Indenture and all references to the Notes shall include the Additional Securities unless the context otherwise requires; provided that no Event of Default with respect to the Notes shall have occurred and be continuing; provided further
that if any such Additional Securities are not fungible with the Notes for U.S. federal income tax purposes, such Additional Securities shall have a separate CUSIP number and shall not constitute a single series with such Notes. 

Events of Default. If an Event of Default with respect to the Notes shall have occurred and be continuing, the principal of the
Notes may be declared due and payable in the manner and with the effect provided in the Indenture. 
 Sinking Fund. The
Notes are not subject to any sinking fund. 

 Special Mandatory Redemption. If, for any reason, the initial public offering of the
Company’s Class A common stock pursuant to an effective registration statement filed with the Commission pursuant to the Securities Act is not completed on or prior to August 31, 2013, or if on an earlier date Pfizer notifies the
Company that it has determined, in its sole discretion, that the initial public offering will not be consummated, the Notes shall become due and payable on the Special Mandatory Redemption Date at the Special Mandatory Redemption Price. 

Optional Redemption. The Notes will be redeemable at any time, at the option of the Company, in whole or from time to time in
part, upon not less than 30 nor more than 60 days’ prior notice, on any date prior to their Maturity at a redemption price, calculated pursuant to the Indenture, which includes accrued interest thereon, if any, to, but excluding, the Redemption
Date. In the case of any partial redemption, selection of the Notes for redemption will be made by the Trustee in accordance with the procedures of DTC. If any Note is to be redeemed in part only, the notice of redemption relating to such Note shall
state the portion of the principal amount thereof to be redeemed; provided that the principal amount of any Note remaining outstanding after a redemption in part shall be $2,000 or a higher integral multiple of $1,000. A new Note in principal
amount equal to the unredeemed portion thereof will be issued in the name of the Holder thereof upon cancellation of this Note. 

Repurchase upon a Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event with respect to
the Notes, the Company shall be required to make an offer to repurchase the Notes on the terms set forth in the Indenture. 

Restrictive Covenants. The Indenture contains certain covenants that, among other things, limit the ability of the Company and its
Subsidiaries to create liens or the ability of the Company to consolidate, merge or sell, transfer or lease all or substantially all of its assets. 
 Defeasance and Covenant Defeasance. The Indenture contains provisions for defeasance at any time of (a) the entire indebtedness of the Company on this Note and (b) certain restrictive
covenants and the related Defaults and Events of Default, upon compliance by the Company with certain conditions set forth therein, which provisions apply to this Note. 
 Modification and Waivers; Obligations of the Company Absolute. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and
obligations of the Company and the rights of the Holders of the Securities of each series. Such amendment may be effected under the Indenture at any time by the Company, and the Trustee with the consent of the Holders of not less than a majority in
aggregate principal amount of the outstanding Notes of each series affected thereby. The Indenture also contains provisions permitting the Holders of not less than a majority in aggregate principal amount of the Securities at the time outstanding,
on behalf of the Holders of all outstanding Securities, to waive compliance by the Company with certain provisions of the Indenture. Furthermore, provisions in the Indenture permit the Holders of not less than a majority in aggregate principal
amount of the outstanding Securities of individual series to waive on behalf of all of the Holders of Securities of such individual series certain past defaults under the Indenture and their consequences. Any such consent or waiver shall be
conclusive and binding upon the Holder of this Note and upon all 

 
future Holders of this Note and of any Note issued upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not notation of such consent or waiver is made upon
this Note. 
 No reference herein to the Indenture and no provision of this Note or of the Indenture shall alter or impair the
obligation of the Company, which is absolute and unconditional, to pay the principal of and interest on this Note at the time, place, and rate, and in the currency, herein prescribed. 

No Recourse Against Others. No director, officer, agent, employee, incorporator, stockholder, partner, member, or manager of the
Company shall have any liability for any obligations of the Company under any Notes or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder of the Notes by accepting a Note waives
and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. 

Limitation on Suits. As set forth in, and subject to, the provisions of the Indenture, no Holder of any Note will have any right
to institute any proceeding with respect to the Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default with respect to this series, the Holders of not
less than 33% in principal amount of the outstanding Notes shall have made written request, and offered indemnity satisfactory to the Trustee, to the Trustee to institute such proceedings as Trustee, and the Trustee shall not have received from the
Holders of a majority in principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days; provided, however, that such limitations do not apply to a suit
instituted by the Holder hereof for the enforcement of payment of the principal of or interest on this Note on or after the respective due dates expressed herein. 
 Authorized Denominations. The Notes are issuable only in registered form without coupons in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. 

Registration of Transfer or Exchange. As provided in the Indenture and subject to certain limitations herein and therein set
forth, the transfer of this Note is registrable in the register of the Notes maintained by the Security Registrar upon surrender of this Note for registration of transfer, at the office or agency of the Company in any place where the principal of
and interest on this Note are payable, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar, duly executed by the Holder hereof or his attorney duly authorized in
writing, and thereupon one or more new Notes, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

As provided in the Indenture and subject to certain limitations herein and therein set forth, the Notes are exchangeable for a like
aggregate principal amount of Notes of different authorized denominations, as requested by the Holders surrendering the same. 

 No service charge shall be made for any such registration of transfer or exchange, but the
Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Holder as the owner hereof for all purposes (except with respect to certain payments of Defaulted Interest), whether or not this Note be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to
the contrary. 
 [Include in any Restricted Note: 
 Additional Rights of Holders of Restricted Global Notes and Restricted Certificated Notes. Pursuant to, but subject to the exceptions in, the Registration Rights Agreement dated as of
January 28, 2013 (as amended, supplemented or otherwise modified, the “Registration Rights Agreement”) among the Company and the Representatives of the Initial Purchasers party thereto with respect to the Notes, the Company
will be obligated to consummate an exchange offer pursuant to which the Holder of this Note shall have the right to exchange this Note for a like principal amount of debt securities of the Company which shall have been registered under the
Securities Act having terms identical in all material respects to this Note (except for the transfer restrictions relating to this Note and except that such note shall not be entitled to Additional Interest (as defined in the Registration Rights
Agreement)). The Holders shall be entitled to receive certain Additional Interest (as defined in the Registration Rights Agreement) in the event such exchange offer is not consummated or the Notes are not offered for resale and upon certain other
conditions, all pursuant to the terms of the Registration Rights Agreement.] 
 Defined Terms. All terms used in this
Note, which are defined in the Indenture and are not otherwise defined herein, shall have the meanings assigned to them in the Indenture. 
 Governing Law. This Note shall be governed by and construed in accordance with the laws of the State of New York. 
 Unless the certificate of authentication hereon has been executed by the Trustee by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose. 
 [Remainder of page intentionally left blank] 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed and its seal
to be hereunto affixed and attested. 
 Dated: 

 

			
	ZOETIS INC., as the Company
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	Attest:
		
	By:	 	  

		 	Name:
		 	Title:

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein referred to in the within-mentioned Indenture, as such is supplemented by the
within-mentioned First Supplemental Indenture. 
  

			
	DEUTSCHE BANK TRUST COMPANY AMERICAS, as Trustee
		
	By:	 	Deutsche Bank National Trust Company
		
	 By:
	 	  

		 	 Name:

		 	 Title:

 Dated: 

 ASSIGNMENT FORM 
 I or we assign and transfer this Note to 
  

 
  

 
 (Print or type name, address and zip code of
assignee or transferee) 
  
  

(Insert Social Security or other identifying number of assignee or transferee) 
 and irrevocably appoint
                                         
                                        agent to
transfer this Note on the books of the Company. The agent may substitute another to act for him. 
  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)

 [Include in any Restricted Securities: Transfer Certification for Restricted Securities: 

In connection with any transfer of this Note occurring prior to the date following the first anniversary of the original issuance of this
Note, the undersigned confirms that it has not utilized any general solicitation or general advertising in connection with the transfer: 
 [Check One] 
  

			
	(1)             	  	to the Company or a subsidiary thereof; or
		
	(2)             	  	pursuant to and in compliance with Rule 144A under the Securities Act; or
		
	(3)             	  	outside the United States in compliance with Regulation S under the Securities Act; or
		
	(4)             	  	pursuant to the exemption from registration provided by Rule 144 under the Securities Act; or
		
	(5)             	  	pursuant to an effective registration statement under the Securities Act; or
		
	(6)             	  	pursuant to another available exemption from the registration statement requirements of the Securities Act.

 Unless one of the items is checked, the Trustee will refuse to register any of the Notes
evidenced by this certificate in the name of any person other than the registered Holder thereof; provided, however, that if item (3), (4) or (6) is checked, the Company or the Trustee may require, prior to registering any such
transfer of the Notes, in their sole discretion, such written legal opinions, certifications) and other information as the Company or the Trustee has reasonably requested to confirm that such transfer is being made pursuant to an exemption from, or
in a transaction not subject to, the registration requirements of the Securities Act. 
 If none of the foregoing items are
checked, the Trustee or Registrar shall not be obligated to register this Note in the name of any person other than the Holder hereof unless and until the conditions to any such transfer of registration set forth herein shall have been satisfied.

  

									
	Dated:	 	  
	 		 	Signed:	 	  

		 		 		 	(Sign exactly as name appears on the other side of this Note)
			
	Signature Guarantee:	 		 	  

		 		 		 	Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor program reasonably acceptable to the Trustee)]

 Rule 144A Certificate 
 TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED 
 The undersigned
represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises sole investment discretion and that it and any such account is a “qualified institutional buyer” within the
meaning of Rule 144A under the Securities Act and is aware that the sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A
or has determined not to request such information and that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 

 

							
	Dated:	 	  
	 		 	  

		 		 		 	NOTICE: To be executed by an executive officer

 Regulation S Certificate 
 TO BE COMPLETED BY TRANSFEROR IF (3) ABOVE IS CHECKED 
 Terms are used in below are as used in
Regulation S (“Regulation S”) under the Securities Act of 1933, as amended (the “Securities Act”), except as otherwise stated herein. 
 The undersigned represents and warrants: 
  

	1.	The offer and sale of the Notes was not and will not be made to a person in the United States (unless such person is excluded from the definition of “U.S.
person” pursuant to Rule 902(k)(2)(vi) or the account held by it for which it is acting is excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3)) and such offer
and sale was not and will not be specifically targeted at an identifiable group of U.S. citizens abroad. 

  

	2.	Unless the circumstances described in the parenthetical in paragraph 1 above are applicable, either (a) at the time the buy order was originated, the buyer was
outside the United States or the undersigned and any person acting on our behalf reasonably believed that the buyer was outside the United States or (b) the transaction was executed in, on or through the facilities of a designated offshore
securities market, and neither the undersigned nor any person acting on behalf of the undersigned knows that the transaction was pre-arranged with a buyer in the United States. 

 

	3.	Neither the undersigned, any affiliate of the undersigned, nor any person acting on behalf of the undersigned or its affiliates has made any directed selling efforts in
the United States with respect to the Notes. 

  

	4.	The proposed transfer of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

			
	Dated:	 	  

 [Attach to Global Note only] 

SCHEDULE OF INCREASES AND DECREASES IN GLOBAL NOTE 
 Zoetis Inc. 
 4.700% Senior Note due 2043 

The initial principal amount of this Global Note is $[        ]. The following increases or
decreases in this Global Note have been made: 
  

									
	 Date
	  	Amount of decrease
in Principal 
Amount
of this Global Note	  	Amount of increase
in Principal 
Amount
of this Global Note	  	Principal Amount of
this Global Note
following such
decrease or increase	  	Signature of
authorized signatory
of Trustee or Note
Custodian
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

 EXHIBIT E 
 RESTRICTED LEGEND 
 THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR OF A BENEFICIAL INTEREST HEREIN, THE ACQUIRER

 (1) REPRESENTS THAT 
 (A) IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT) AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION
WITH RESPECT TO EACH SUCH ACCOUNT, OR 
 (B) IT IS NOT A U.S. PERSON (WITHIN THE MEANING OF REGULATION S UNDER
THE SECURITIES ACT) AND 
 (2) AGREES FOR THE BENEFIT OF THE COMPANY THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE TRANSFER
THIS NOTE OR ANY BENEFICIAL INTEREST HEREIN, EXCEPT IN ACCORDANCE WITH THE SECURITIES ACT AND ANY APPLICABLE SECURITIES LAWS OF ANY STATE OF THE UNITED STATES AND ONLY 

(A) TO THE COMPANY, 
 (B) PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT, 
 (C) TO A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT, 
 (D) IN AN OFFSHORE TRANSACTION IN COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE SECURITIES ACT, OR 
 (E) PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT OR ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 

 PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH (2)(C) OR (D) ABOVE,
A DULY COMPLETED AND SIGNED CERTIFICATE (THE FORM OF WHICH MAY BE OBTAINED FROM THE TRUSTEE) MUST BE DELIVERED TO THE TRUSTEE. PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH (2)(E) ABOVE, THE COMPANY RESERVES THE RIGHT TO REQUIRE
THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY BE REQUIRED IN ORDER TO DETERMINE THAT THE PROPOSED TRANSFER IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. NO
REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY RULE 144 EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 

 EXHIBIT F 
 DTC LEGEND 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE
OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH
OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR
OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS A BENEFICIAL INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL NOTE ARE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF CEDE & CO. OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF
THIS GLOBAL NOTE ARE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE TRANSFER PROVISIONS OF THE INDENTURE. 

 EXHIBIT G 
 Regulation S Certificate 

            ,
         
 Deutsche Bank Trust Company Americas, as Trustee 

Trust & Agency Services 
 60 Wall
Street, MS NYC60-2710 
 New York, New York 10005 

	Attn:	Corporates Team Deal Manager – Zoetis Inc. 

	Fax#	(732) 578-4635 

 Zoetis Inc.
[    ]% Senior Notes due 20[    ] (the “Notes”) issued under the Indenture as supplemented by the First Supplemental Indenture (collectively, the “Indenture”), each dated as
of January [    ], 2013 relating to the Notes 
 Ladies and Gentlemen: 

Terms are used in this Certificate as used in Regulation S (“Regulation S”) under the Securities Act of 1933, as amended
(the “Securities Act”), except as otherwise stated herein. 
 [CHECK A OR B AS APPLICABLE.] 

 

	 	 ̈      A.	This Certificate relates to our proposed transfer of $             principal amount of Notes issued under
the Indenture. We hereby certify as follows: 

  

	 	1.	The offer and sale of the Notes was not and will not be made to a person in the United States (unless such person is excluded from the definition of “U.S.
person” pursuant to Rule 902(k)(2)(vi) or the account held by it for which it is acting is excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3)) and such offer
and sale was not and will not be specifically targeted at an identifiable group of U.S. citizens abroad. 

  

	 	2.	 Unless the circumstances described in the parenthetical in paragraph 1 above are applicable, either (a) at the time the

	 	
buy order was originated, the buyer was outside the United States or we and any person acting on our behalf reasonably believed that the buyer was outside the United States or (b) the
transaction was executed in, on or through the facilities of a designated offshore securities market, and neither we nor any person acting on our behalf knows that the transaction was pre-arranged with a buyer in the United States.

  

	 	3.	Neither we, any of our affiliates, nor any person acting on our or their behalf has made any directed selling efforts in the United States with respect to the Notes.

  

	 	4.	The proposed transfer of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

 

	 	5.	If we are a dealer or a person receiving a selling concession, fee or other remuneration in respect of the Notes, and the proposed transfer takes place during the
Restricted Period (as defined in the Indenture), or we are an officer or director of the Company or an Initial Purchaser (as defined in the Indenture), we certify that the proposed transfer is being made in accordance with the provisions of Rule
904(b) of Regulation S. 

  

	 	 ̈      B.	This Certificate relates to our proposed exchange of $             principal amount of Notes issued under
the Indenture for an equal principal amount of Notes to be held by us. We hereby certify as follows: 

  

	 	1.	At the time the offer and sale of the Notes was made to us, either (i) we were not in the United States or (ii) we were excluded from the definition of
“U.S. person” pursuant to Rule 902(k)(2)(vi) or the account held by us for which we were acting was excluded from the definition of “U.S. person” pursuant to Rule 902(k)(2)(i) under the circumstances described in Rule 902(h)(3);
and we were not a member of an identifiable group of U.S. citizens abroad. 

  

	 	2.	Unless the circumstances described in paragraph 1(ii) above are applicable, either (a) at the time our buy order was originated, we were outside the United States
or (b) the transaction was executed in, on or through the facilities of a designated offshore securities market and we did not pre-arrange the transaction in the United States. 

	 	3.	The proposed exchange of Notes is not part of a plan or scheme to evade the registration requirements of the Securities Act. 

You and the Company are entitled to rely upon this Certificate and are irrevocably authorized to produce this Certificate or a copy
hereof to any interested party in any administrative or legal proceeding or official inquiry with respect to the matters covered hereby. 
  

			
	Very truly yours,
	
	[NAME OF SELLER (FOR TRANSFERS) OR OWNER (FOR EXCHANGES)]
		
	By:	 	  

		 	Name:
		 	Title:
		 	Address:

  

			
	Date:	 	  

 EXHIBIT H 
 Rule 144A Certificate 

            ,
         
 Deutsche Bank Trust Company Americas, as Trustee 

Trust & Agency Services 
 60 Wall
Street, MS NYC60-2710 
 New York, New York 10005 

	Attn:	Corporates Team Deal Manager – Zoetis Inc. 

	Fax#	(732) 578-4635 

 Zoetis Inc.
[    ]% Senior Notes due 20[    ] (the “Notes”) issued under the Indenture as supplemented by the First Supplemental Indenture (collectively, the “Indenture”), each dated as
of January [    ], 2013 relating to the Notes 
 Ladies and Gentlemen: 

TO BE COMPLETED BY PURCHASER IF (1) ABOVE IS CHECKED. 
 This Certificate relates to: 
 [CHECK A OR B AS APPLICABLE.] 

 

	 	 ̈      A.	Our proposed purchase of $             principal amount of Notes issued under the Indenture.

  

	 	 ̈      B.	Our proposed exchange of $             principal amount of Notes issued under the Indenture for an equal
principal amount of Notes to be held by us. 

 We and, if applicable, each account for which we are acting in the
aggregate owned and invested more than $100,000,000 in securities of issuers that are not affiliated with us (or such accounts, if applicable), as of             ,
20    , which is a date on or since close of our most recent fiscal year. We and, if applicable, each account for which we are acting, are a qualified institutional buyer within the meaning of Rule 144A (“Rule
144A”) under the Securities Act of 1933, as amended (the “Securities Act”). If we are acting on behalf of an 

 
account, we exercise sole investment discretion with respect to such account. We are aware that the transfer of Notes to us, or such exchange, as applicable, is being made in reliance upon the
exemption from the provisions of Section 5 of the Securities Act provided by Rule 144A. Prior to the date of this Certificate we have received such information regarding the Company as we have requested pursuant to Rule 144A(d)(4) or have
determined not to request such information. 
 You and the Company are entitled to rely upon this Certificate and are
irrevocably authorized to produce this Certificate or a copy hereof to any interested party in any administrative or legal proceeding or official inquiry with respect to the matters covered hereby. 

 

			
	Very truly yours,
	
	[NAME OF PURCHASER (FOR TRANSFERS) OR OWNER (FOR EXCHANGES)]
		
	By:	 	  

		 	Name:
		 	Title:
		 	Address:

  

			
	Date:	 	  

 EXHIBIT I 
 [COMPLETE FORM I OR FORM II AS APPLICABLE.] 
 [FORM I] 

Certificate of Beneficial Ownership 
  

	To:	Deutsche Bank Trust Company Americas, as Trustee 

	Trust	& Agency Services 

 60 Wall Street, MS
NYC60-2710 
 New York, New York 10005 

	Attn:	Corporates Team Deal Manager – Zoetis Inc. 

	Fax#	(732) 578-4635 

 OR 

[Name of DTC Participant] 
 Zoetis Inc. [    ]% Senior Notes due 20[    ] (the “Notes”) issued under the Indenture as supplemented by the First Supplemental Indenture
(collectively, the “Indenture”), each dated as of January [    ], 2013 relating to the Notes 
 Ladies and
Gentlemen: 
 We are the beneficial owner of $             principal
amount of Notes issued under the Indenture and represented by a Temporary Offshore Global Note (as defined in the Indenture). 

We hereby certify as follows: 
 [CHECK A OR B AS APPLICABLE.] 
  

	 	 ̈      A.	We are a non-U.S. person (within the meaning of Regulation S under the Securities Act of 1933, as amended). 

 

	 	 ̈      B.	We are a U.S. person (within the meaning of Regulation S under the Securities Act of 1933, as amended) that purchased the Notes in a transaction that did not require
registration under the Securities Act of 1933, as amended. 

 You and the Company are entitled to rely upon this
Certificate and are irrevocably authorized to produce this Certificate or a copy hereof to any 

 
interested party in any administrative or legal proceeding or official inquiry with respect to the matters covered hereby. 

			
	Very truly yours,
	
	[NAME OF BENEFICIAL OWNER]
		
	By:	 	  

		 	Name:
		 	Title:
		 	Address:

  

			
	Date:	 	  

 [FORM II] 
 Certificate of Beneficial Ownership 
 Deutsche Bank Trust Company Americas,
as Trustee 
 Trust & Agency Services 
 60 Wall Street, MS NYC60-2710 
 New York, New York 10005 

	 	Attn:	Corporates Team Deal Manager – Zoetis Inc. 

	 	Fax#	(732) 578-4635 

 Zoetis Inc.
[    ]% Senior Notes due 20[    ] (the “Notes”) issued under the Indenture as supplemented by the First Supplemental Indenture (collectively, the “Indenture”), each dated as
of January [    ], 2013 relating to the Notes 
 Ladies and Gentlemen: 

This is to certify that based solely on certifications we have received in writing, by tested telex or by electronic transmission from
Institutions appearing in our records as persons being entitled to a portion of the principal amount of Notes represented by a Temporary Offshore Global Note issued under the above-referenced Indenture, that as of the date hereof,
$             principal amount of Notes represented by the Temporary Offshore Global Note being submitted herewith for exchange is beneficially owned by persons that are either
(i) non-U.S. persons (within the meaning of Regulation S under the Securities Act of 1933, as amended) or (ii) U.S. persons that purchased the Notes in a transaction that did not require registration under the Securities Act of 1933, as
amended. 
 We further certify that (i) we are not submitting herewith for exchange any portion of such Temporary Offshore
Global Note excepted in such certifications 

 
and (ii) as of the date hereof we have not received any notification from any Institution to the effect that the statements made by such Institution with respect to any portion of such
Temporary Offshore Global Note submitted herewith for exchange are no longer true and cannot be relied upon as of the date hereof. 
 You and the Company are entitled to rely upon this Certificate and are irrevocably authorized to produce this Certificate or a copy hereof to any interested party in any administrative or legal proceeding
or official inquiry with respect to the matters covered hereby. 
  

			
	Yours faithfully,
	
	[Name of DTC Participant]
		
	By:	 	  

		 	Name:
		 	Title:
		 	Address:

  

			
	Date:	 	  

 EXHIBIT J 
 THIS NOTE IS A TEMPORARY GLOBAL NOTE. PRIOR TO THE EXPIRATION OF THE RESTRICTED PERIOD APPLICABLE HERETO, BENEFICIAL INTERESTS HEREIN MAY NOT BE HELD BY ANY PERSON OTHER THAN (1) A NON-U.S. PERSON OR
(2) A U.S. PERSON THAT PURCHASED SUCH INTEREST IN A TRANSACTION EXEMPT FROM REGISTRATION UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”). BENEFICIAL INTERESTS HEREIN ARE NOT EXCHANGEABLE FOR PHYSICAL
NOTES OTHER THAN A PERMANENT GLOBAL NOTE IN ACCORDANCE WITH THE TERMS OF THE INDENTURE. TERMS IN THIS LEGEND ARE USED AS USED IN REGULATION S UNDER THE SECURITIES ACT. 
 NO BENEFICIAL OWNERS OF THIS TEMPORARY GLOBAL NOTE SHALL BE ENTITLED TO RECEIVE PAYMENT OF PRINCIPAL OR INTEREST HEREON UNTIL SUCH BENEFICIAL INTEREST IS EXCHANGED OR TRANSFERRED FOR AN INTEREST IN
ANOTHER NOTE.Registration Rights Agreement

 Exhibit 10.20 
 REGISTRATION RIGHTS AGREEMENT 
 by and among 

Zoetis Inc. 
 and 
 Merrill Lynch, Pierce, Fenner & Smith Incorporated,

 Barclays Capital Inc. 
 J.P. Morgan Securities LLC 
 and 

Deutsche Bank Securities Inc., 
 as Representatives of the several 
 Initial Purchasers 

Dated as of January 28, 2013 

 REGISTRATION RIGHTS AGREEMENT 

This Registration Rights Agreement (this “Agreement”) is made and entered into as of January 28, 2013, by and among Zoetis
Inc., a Delaware corporation (the “Company”), and Merrill Lynch, Pierce, Fenner & Smith Incorporated, Barclays Capital Inc., J.P. Morgan Securities LLC and Deutsche Bank Securities Inc., as representatives of the several Initial
Purchasers (collectively, the “Initial Purchasers”) named in the Purchase Agreement (as defined below), each of which has agreed to purchase the Company’s 1.150% Senior Notes due 2016, 1.875% Senior Notes due 2018, 3.250% Senior Notes
due 2023 and 4.700% Senior Notes due 2043 (collectively, the “Initial Securities”) pursuant to the Purchase Agreement. 
 This Agreement is made pursuant to the Purchase Agreement, dated January 16, 2013 (the “Purchase Agreement”), between the Company and the Initial Purchasers for the benefit of the holders
from time to time of the Initial Securities, including the Initial Purchasers. In order to induce the Initial Purchasers to purchase the Initial Securities, the Company has agreed to provide the registration rights set forth in this Agreement. The
execution and delivery of this Agreement is a condition to the obligations of the Initial Purchasers set forth in Section 8(k) of the Purchase Agreement. 
 The parties hereby agree as follows: 
 SECTION 1. Definitions. As used
in this Agreement, the following capitalized terms shall have the following meanings: 
 Additional Interest: As defined
in Section 5 hereof. 
 Additional Interest Payment Date: With respect to the Initial Securities, each Interest
Payment Date. 
 Broker-Dealer: Any broker or dealer registered under the Exchange Act. 

Business Day: Any day other than a Saturday, Sunday or U.S. federal holiday or a day on which banking institutions or trust
companies located in New York, New York are authorized or obligated to be closed. 
 Closing Date: The date of this
Agreement. 
 Commission: The Securities and Exchange Commission. 

Company: As defined in the preamble hereto. 
 Consummate: A registered Exchange Offer shall be deemed “Consummated” for purposes of this Agreement upon the occurrence of (i) the filing and effectiveness under the Securities Act
of the Exchange Offer Registration Statement relating to the Exchange Securities to be issued in the Exchange Offer, (ii) the maintenance of such Registration Statement continuously effective and the keeping of the Exchange Offer open for a
period not less than the minimum period required pursuant to Section 3(b) hereof, and (iii) the delivery by the Company to the Security 

 
Registrar under the Indenture of Exchange Securities in the same aggregate principal amount as the aggregate principal amount of Initial Securities that were validly tendered and not withdrawn by
Holders thereof pursuant to the Exchange Offer. 
 Effectiveness Target Date: As defined in Section 5 hereof.

 Exchange Act: The Securities Exchange Act of 1934, as amended. 

Exchange Offer: The registration by the Company under the Securities Act of the Exchange Securities on a Registration Statement
pursuant to which the Company offers the Holders of all outstanding Transfer Restricted Securities the opportunity to exchange all such outstanding Transfer Restricted Securities held by such Holders for Exchange Securities in an aggregate principal
amount equal to the aggregate principal amount of the Transfer Restricted Securities that were validly tendered and not withdrawn in such exchange offer by such Holders. 
 Exchange Offer Registration Statement: The Registration Statement relating to the Exchange Offer, including the related Prospectus. 

Exempt Resales: The transactions in which the Initial Purchasers propose to sell the Initial Securities to certain “qualified
institutional buyers,” as such term is defined in Rule 144A under the Securities Act and to certain non-U.S. persons pursuant to Regulation S under the Securities Act. 
 Exchange Securities: The 1.150% Senior Notes due 2016, 1.875% Senior Notes due 2018, 3.250% Senior Notes due 2023 and 4.700% Senior Notes due 2043, of the same series under the Indenture as the
Initial Securities, to be issued to Holders in exchange for Transfer Restricted Securities pursuant to this Agreement. 

FINRA: Financial Industry Regulatory Authority, Inc. 
 Holders: As defined in Section 2(b) hereof. 
 Indemnified Holder:
As defined in Section 8(a) hereof. 
 Indenture: The Indenture, dated as of January 28, 2013, by and
between the Company and Deutsche Bank Trust Company Americas, as trustee (the “Trustee”), as supplemented by the First Supplemental Indenture, dated as of January 28, 2013, by and between the Company and the Trustee, pursuant to which
the Securities are to be issued, as such Indenture is amended or supplemented from time to time in accordance with the terms thereof. 
 Initial Purchasers: As defined in the preamble hereto. 
 Initial
Placement: The sale by the Company and by the Selling Noteholders (as defined in the Purchase Agreement) of the Initial Securities to the Initial Purchasers pursuant to the Purchase Agreement. 

Initial Securities: As defined in the preamble hereto. 

  
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 Interest Payment Date: As defined in the Indenture and the Securities. 

Person: An individual, partnership, corporation, limited liability company, trust or unincorporated organization, other legal
entity or a government or agency or political subdivision thereof. 
 Prospectus: The prospectus included in a
Registration Statement, as amended or supplemented by any prospectus supplement and by all other amendments thereto, including post-effective amendments, and all material incorporated by reference into such Prospectus. 

Purchase Agreement: As defined in the preamble hereto. 
 Registration Default: As defined in Section 5 hereof. 

Registration Statement: Any registration statement of the Company relating to (a) an offering of Exchange Securities pursuant
to an Exchange Offer or (b) the registration for resale of Transfer Restricted Securities pursuant to the Shelf Registration Statement, which is filed pursuant to the provisions of this Agreement, in each case, including the Prospectus included
therein, all amendments and supplements thereto (including post-effective amendments) and all exhibits and material incorporated by reference therein. 
 Representatives: As defined in the preamble to the Purchase Agreement. 

Securities: The Initial Securities and/or the Exchange Securities. 

Securities Act: The Securities Act of 1933, as amended. 
 Shelf Filing Deadline: As defined in Section 4(a) hereof. 
 Shelf
Registration Statement: As defined in Section 4(a) hereof. 
 Transfer Restricted Securities: Each Initial
Security, until the earliest to occur of (a) the date on which such Initial Security is exchanged by a person other than a Broker-Dealer in the Exchange Offer for an Exchange Security , (b) the date on which such Initial Security has been
effectively registered under the Securities Act and disposed of in accordance with a Shelf Registration Statement and (c) the date on which such Initial Security is distributed to the public by a Broker-Dealer pursuant to the “Plan of
Distribution” contemplated by the Exchange Offer Registration Statement (including delivery of the Prospectus contained therein) or, following the exchange by a Broker-Dealer in the Exchange Offer of an Initial Security for an Exchange
Security, the date on which such Exchange Security is sold to a purchaser who received from such Broker-Dealer on or prior to the date of such sale a copy of the Prospectus contained in the Exchange Offer Registration Statement. 

Trust Indenture Act: The Trust Indenture Act of 1939, as amended. 

Underwritten Registration or Underwritten Offering: A registration in which securities of the Company are sold to an underwriter
for reoffering to the public. 

  
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 SECTION 2. Securities Subject to this Agreement. 

(a) Transfer Restricted Securities. The securities entitled to the benefits of this Agreement are the Transfer Restricted
Securities. 
 (b) Holders of Transfer Restricted Securities. A Person is deemed to be a holder of Transfer Restricted
Securities (each, a “Holder”) whenever such Person owns Transfer Restricted Securities. 
 SECTION 3.
Registered Exchange Offer. 
 (a) Unless the Exchange Offer shall not be permissible under applicable law or Commission
policy (after the procedures set forth in Section 6(a) hereof have been complied with), the Company shall (i) use its commercially reasonable efforts to cause to be filed with the Commission a Registration Statement under the Securities
Act relating to the Exchange Securities and the Exchange Offer, (ii) use its commercially reasonable efforts to cause to cause such Registration Statement to be declared effective by the Commission and (iii) in connection with the
foregoing, file (A) all pre-effective amendments to such Registration Statement as may be necessary in order to cause such Registration Statement to be declared effective by the Commission, (B) if applicable, a post-effective amendment to
such Registration Statement pursuant to Rule 430A under the Securities Act and (C) use its commercially reasonable efforts to cause all necessary filings in connection with the registration and qualification of the Exchange Securities to be
made under the state securities or blue sky laws of such jurisdictions as are necessary to permit Consummation of the Exchange Offer. The Exchange Offer shall be on the appropriate form permitting registration of the Exchange Securities to be
offered in exchange for the Transfer Restricted Securities and to permit resales of Initial Securities held by Broker-Dealers as contemplated by Section 3(c) hereof. 
 (b) The Company shall cause the Exchange Offer Registration Statement to be effective continuously and shall keep the Exchange Offer open for a period of not less than the minimum period required under
applicable federal securities laws to Consummate the Exchange Offer; provided, however, that in no event shall such period be less than 20 Business Days after the date notice of the Exchange Offer is mailed to the Holders. The Company shall
cause and use its commercially reasonable efforts to cause the Exchange Offer to comply with all applicable federal and state, respectively, securities laws. No securities other than the Exchange Securities shall be included in the Exchange Offer
Registration Statement. The Company shall use its commercially reasonable efforts to cause the Exchange Offer to be Consummated on the earliest practicable date after the Exchange Offer Registration Statement has been declared effective by the
Commission, but in no event later than 365 days after the Closing Date (or if such 365th day is not a Business Day, the next succeeding Business Day). 
 (c) The Company shall indicate in a “Plan of Distribution” section contained in the Prospectus forming a part of the Exchange Offer Registration Statement that any Broker-Dealer who holds
Initial Securities that are Transfer Restricted Securities and that were acquired for its own account as a result of market-making activities or other trading activities (other than Transfer Restricted Securities acquired directly from the Company),
may exchange such Initial Securities 

  
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pursuant to the Exchange Offer; however, such Broker-Dealer may be deemed to be an “underwriter” within the meaning of the Securities Act and must, therefore, deliver a prospectus
meeting the requirements of the Securities Act in connection with any resales of the Exchange Securities received by such Broker-Dealer in the Exchange Offer, which prospectus delivery requirement may be satisfied by the delivery by such
Broker-Dealer of the Prospectus contained in the Exchange Offer Registration Statement. Such “Plan of Distribution” section shall also contain all other information with respect to such resales by Broker-Dealers that the Commission may
require in order to permit such resales pursuant thereto, but such “Plan of Distribution” shall not name any such Broker-Dealer or disclose the amount of Initial Securities held by any such Broker-Dealer except to the extent required by
the Commission. 
 The Company shall use its commercially reasonable efforts to keep the Exchange Offer Registration Statement
continuously effective, supplemented and amended as required by the provisions of Section 6(c) hereof to the extent necessary to ensure that it is available for resales of Initial Securities acquired by Broker-Dealers for their own accounts as
a result of market-making activities or other trading activities, and to ensure that it conforms with the requirements of this Agreement, the Securities Act and the policies, rules and regulations of the Commission as announced from time to time,
for a period ending on the earlier of (i) 180 days from the date on which the Exchange Offer Registration Statement is declared effective and (ii) the date on which such Broker-Dealer no longer owns any Transfer Restricted Securities.

 The Company shall provide sufficient copies of the latest version of such Prospectus to Broker-Dealers promptly upon request
at any time during such 180-day (or shorter as provided in the foregoing sentence) period in order to facilitate such resales. 

SECTION 4. Shelf Registration. 
 (a) Shelf Registration. If (i) the Company is not permitted to file an Exchange Offer Registration Statement or to consummate the Exchange Offer because the Exchange Offer is not permitted by
applicable law or Commission policy (after the procedures set forth in Section 6(a) hereof have been complied with), (ii) for any reason the Exchange Offer is not Consummated within 365 days after the Closing Date (or if such 365th day is
not a Business Day, the next succeeding Business Day), or (iii) with respect to any Holder of Transfer Restricted Securities (A) such Holder is prohibited by applicable law or Commission policy from participating in the Exchange Offer, or
(B) such Holder may not resell the Exchange Securities acquired by it in the Exchange Offer to the public without delivering a prospectus and that the Prospectus contained in the Exchange Offer Registration Statement is not appropriate or
available for such resales by such Holder, or (C) such Holder is a Broker-Dealer and holds Initial Securities acquired directly from the Company or one of its affiliates, then, upon such Holder’s request, the Company shall: 

(x) cause to be filed a shelf registration statement pursuant to Rule 415 under the Securities Act, which may be an
amendment to the Exchange Offer Registration Statement (in either event, the “Shelf Registration Statement”) on or prior to the earlier to occur of (1) the 30th day after the date on which the Company determines that it is not
permitted to file the Exchange Offer Registration Statement and (2) the 30th day after the date on which the Company receives notice from a Holder of Transfer Restricted Securities 

  
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as contemplated by clause (iii) above; provided that, in each case, in no event shall the Company be required to cause such Shelf Registration Statement to be filed earlier than the 365th
day after the Closing Date (or if such 365th day is not a Business Day, the next succeeding Business Day) (such earliest date being the “Shelf Filing Deadline”), which Shelf Registration Statement shall provide for resales of all Transfer
Restricted Securities the Holders of which shall have provided the information required pursuant to Section 4(b) hereof; and 
 (y) use their commercially reasonable efforts to cause such Shelf Registration Statement to be declared effective by the Commission on or before the 60th day after the Shelf Filing Deadline (or if such
60th day is not a Business Day, the next succeeding Business Day). 
 The Company shall use its commercially reasonable efforts
to keep such Shelf Registration Statement continuously effective, supplemented and amended as required by the provisions of Sections 6(b) and (c) hereof to the extent necessary to ensure that it is available for resales of Initial Securities by
the Holders of Transfer Restricted Securities entitled to the benefit of this Section 4(a), and to ensure that it conforms with the requirements of this Agreement, the Securities Act and the policies, rules and regulations of the Commission as
announced from time to time, until the earlier of (i) one year after the Closing Date and (ii) the date all Securities registered under the Shelf Registration Statement have been sold as contemplated in the Shelf Registration Statement
(the period during which a Shelf Registration is required to remain continuously effective, the “Shelf Registration Period”). 
 (b) Provision by Holders of Certain Information in Connection with the Shelf Registration Statement. No Holder of Transfer Restricted Securities may include any of its Transfer Restricted
Securities in any Shelf Registration Statement pursuant to this Agreement unless and until such Holder furnishes to the Company in writing, within 20 Business Days after receipt of a request therefor, such information as the Company may reasonably
request for use in connection with any Shelf Registration Statement or Prospectus or preliminary Prospectus included therein. Each Holder as to which any Shelf Registration Statement is being effected agrees to furnish promptly to the Company all
information required to be disclosed in order to make the information previously furnished to the Company by such Holder not materially misleading. 
 SECTION 5. Additional Interest. If (i) the Company has not Consummated the Exchange Offer on or before the day that is 365 days after the Closing Date, (ii) if applicable, a Shelf
Registration Statement covering resales of the Securities has not been filed or declared effective by the Commission on or prior to the date specified for such effectiveness in this Agreement (the “Effectiveness Target Date”), or
(iii) if applicable, after the Shelf Registration Statement required by this Agreement is filed and is declared effective but shall thereafter cease to be effective or fail to be usable for its intended purpose at any time during the Shelf
Registration Period without being immediately replaced by a comparable Registration Statement filed and declared effective by the Commission (each such event referred to in clauses (i) through (iii), a “Registration Default”), the
Company hereby agrees that the interest rate borne by the Transfer Restricted Securities (“Additional Interest”) shall accrue on the principal amount of the Transfer Restricted Securities at a rate of 0.25% per annum for the first
90-day period immediately following 

  
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such Registration Default and by an additional 0.25% per annum with respect to each subsequent 90-day period, up to a maximum rate of 1.00% per annum, until all Registration Defaults
have been cured or such affected Securities ceases to be Transfer Restricted Securities, the interest rate borne by the relevant Transfer Restricted Securities will be reduced to the original interest rate borne by such Transfer Restricted
Securities; provided, however, that, if after any such reduction in interest rate, a different Registration Default occurs, the interest rate borne by the relevant Transfer Restricted Securities shall again be increased pursuant to the foregoing
provisions. 
 All obligations of the Company set forth in the preceding paragraph that are outstanding with respect to any
Transfer Restricted Security at the time such Security ceases to be a Transfer Restricted Security shall survive until such time as all such obligations with respect to such Security shall have been satisfied in full. The accrual of such additional
interest shall be the exclusive monetary remedy available to Holders for any Registration Default. 
 SECTION 6.
Registration Procedures. 
 (a) Exchange Offer Registration Statement. In connection with the Exchange Offer, the
Company shall comply with all of the provisions of Section 6(c) hereof, shall use its commercially reasonable efforts to effect such exchange to permit the sale of Transfer Restricted Securities being sold in accordance with the intended method
or methods of distribution thereof, and the Company and each Holder shall comply with all of the following provisions: 
 (i) If in the reasonable opinion of counsel to the Company there is a question as to whether the Exchange Offer is permitted by applicable law, subject to Section 4, the Company hereby agrees to seek
a no-action letter or other favorable decision from the Commission allowing the Company to Consummate an Exchange Offer for such Initial Securities. The Company hereby agrees to pursue the issuance of such a decision to the Commission staff level
but shall not be required to take commercially unreasonable action to effect a change of Commission policy. The Company hereby agrees, however, to (A) participate in telephonic conferences with the Commission, (B) deliver to the Commission
staff an analysis prepared by counsel to the Company setting forth the legal bases, if any, upon which such counsel has concluded that such an Exchange Offer should be permitted and (C) diligently pursue a favorable resolution by the Commission
staff of such submission. 
 (ii) As a condition to its participation in the Exchange Offer pursuant to the terms
of this Agreement, each Holder of Transfer Restricted Securities shall furnish, upon the request of the Company, prior to the Consummation thereof, a written representation to the Company (which may be contained in the letter of transmittal
contemplated by the Exchange Offer Registration Statement) to the effect that (A) it is not an affiliate of the Company, (B) it is not engaged in, and does not intend to engage in, and has no arrangement or understanding with any Person to
participate in, a distribution of the Exchange Securities to be issued in the Exchange Offer and (C) any Exchange Securities to be received by it will be acquired in ordinary course of its business. In addition, all such Holders of Transfer
Restricted Securities shall otherwise cooperate in the Company’s 

  
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preparations for the Exchange Offer. Each Holder hereby acknowledges and agrees that any Broker-Dealer and any such Holder using the Exchange Offer to participate in a distribution of the
securities to be acquired in the Exchange Offer (1) could not under Commission policy as in effect on the date of this Agreement rely on the position of the Commission enunciated in Morgan Stanley and Co., Inc. (available June 5,
1991) and Exxon Capital Holdings Corporation (available May 13, 1988), as interpreted in the Commission’s letter to Shearman & Sterling dated July 2, 1993, and similar no-action letters (which may include any no action
letter obtained pursuant to clause (i) above), and (2) must comply with the registration and prospectus delivery requirements of the Securities Act in connection with a secondary resale transaction and that such a secondary resale
transaction should be covered by an effective registration statement containing the selling security holder information required by Item 507 or 508, as applicable, of Regulation S-K if the resales are of Exchange Securities obtained by such
Holder in exchange for Initial Securities acquired by such Holder directly from the Company. 
 (b) Shelf Registration
Statement. If required pursuant to Section 4, in connection with the Shelf Registration Statement, the Company shall comply with all the provisions of Section 6(c) hereof and shall use its commercially reasonable efforts to effect such
registration to permit the sale of the Transfer Restricted Securities being sold in accordance with the intended method or methods of distribution thereof, and pursuant thereto the Company will as expeditiously as practicable prepare and file with
the Commission a Registration Statement relating to the registration on any appropriate form under the Securities Act, which form shall be available for the sale of the Transfer Restricted Securities in accordance with the intended method or methods
of distribution thereof. 
 (c) General Provisions. In connection with any Registration Statement and any Prospectus
required by this Agreement to permit the sale or resale of Transfer Restricted Securities (including, without limitation, any Registration Statement and the related Prospectus required to permit resales of Initial Securities by Broker-Dealers), the
Company shall: 
 (i) use its commercially reasonable efforts to keep such Registration Statement continuously
effective and provide all requisite financial statements for the period specified in Section 3 or 4 hereof, as applicable; upon the occurrence of any event that would cause any such Registration Statement or the Prospectus contained therein
(A) to contain a material misstatement or omission or (B) not to be effective and usable for resale of Transfer Restricted Securities during the period required by this Agreement, the Company shall file promptly an appropriate amendment to
such Registration Statement, in the case of clause (A), correcting any such misstatement or omission, and, in the case of either clause (A) or (B), use its commercially reasonable efforts to cause such amendment to be declared effective and
such Registration Statement and the related Prospectus to become usable for their intended purpose(s) as soon as practicable thereafter; 
 (ii) prepare and file with the Commission such amendments and post-effective amendments to the applicable Registration Statement as may be necessary to keep the Registration Statement effective for the
applicable period set forth in Section 3 or 4 hereof, as applicable, or such shorter period as will terminate when all Transfer Restricted Securities 

  
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covered by such Registration Statement have been sold; cause the Prospectus to be supplemented by any required Prospectus supplement, and as so supplemented to be filed pursuant to Rule 424 under
the Securities Act, and to comply fully with the applicable provisions of Rules 424 and 430A under the Securities Act in a timely manner; and comply with the provisions of the Securities Act with respect to the disposition of all securities covered
by such Registration Statement during the applicable period in accordance with the intended method or methods of distribution by the sellers thereof set forth in such Registration Statement or supplement to the Prospectus; 

(iii) advise the underwriter(s), if any, and selling Holders, if any, promptly and, if requested by such Persons, to
confirm such advice in writing, (A) when the Prospectus or any Prospectus supplement or post-effective amendment has been filed, and, with respect to any Registration Statement or any post-effective amendment thereto, when the same has been
declared effective by the Commission, (B) of any request by the Commission for amendments to the Registration Statement or amendments or supplements to the Prospectus or for additional information relating thereto, (C) of the issuance by
the Commission of any stop order suspending the effectiveness of the Registration Statement under the Securities Act or of the suspension by any state securities commission of the qualification of the Transfer Restricted Securities for offering or
sale in any jurisdiction, or the initiation of any proceeding for any of the preceding purposes, (D) of the existence of any fact or the happening of any event that makes any statement of a material fact made in the Registration Statement, the
Prospectus, any amendment or supplement thereto, or any document incorporated by reference therein untrue, or that requires the making of any additions to or changes in the Registration Statement or the Prospectus in order to make the statements
therein not misleading. If at any time the Commission shall issue any stop order suspending the effectiveness of the Registration Statement, or any state securities commission or other regulatory authority shall issue an order suspending the
qualification or exemption from qualification of the Transfer Restricted Securities under state securities or blue sky laws, the Company shall use its commercially reasonable efforts to obtain the withdrawal or lifting of such order at the earliest
possible time; 
 (iv) furnish without charge to each of the Initial Purchasers, each selling Holder named in any
Registration Statement, and each of the underwriter(s), if any, before filing with the Commission, copies of any Registration Statement or any Prospectus included therein or any amendments or supplements to any such Registration Statement or
Prospectus (including all documents incorporated by reference therein after the initial filing of such Registration Statement), if not otherwise available on the Commission’s EDGAR system and if the Company in its sole discretion determines it
is appropriate under applicable law, and the Company will not file any such Registration Statement or Prospectus or any amendment or supplement to any such Registration Statement or Prospectus (including all such documents incorporated by reference)
to which a Holder, including any an Initial Purchaser, of Transfer Restricted Securities covered by such Registration Statement or the underwriter(s), if any, shall reasonably object in writing within five Business Days after the receipt thereof
(such objection to be deemed timely made upon confirmation of telecopy transmission within such period). The objection of a Selling Holder or underwriter, if any, shall be deemed to be reasonable if such Registration

  
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Statement, amendment, Prospectus or supplement, as applicable, as proposed to be filed, contains a material misstatement or omission and the objection relates to such matter; 

(v) make available at reasonable times for inspection by the Initial Purchasers, the managing underwriter(s), if any,
participating in any disposition pursuant to a Shelf Registration Statement and any attorney or accountant retained by such Initial Purchasers or any of the underwriter(s), all financial and other records, pertinent corporate documents and
properties of the Company and cause the Company’s officers, directors and employees to supply all information reasonably requested by any such Holder, underwriter, attorney or accountant in connection with such Registration Statement or any
post-effective amendment thereto subsequent to the filing thereof and prior to its effectiveness and to participate in meetings with investors to the extent requested by the managing underwriter(s), if any, and the Company in its sole discretion
determines such “roadshow” will not materially interfere with its business; 
 (vi) if requested by any
selling Holders or the underwriter(s), if any, incorporate in any Shelf Registration Statement or Prospectus thereunder, pursuant to a supplement or post-effective amendment if necessary, such information as such selling Holders and underwriter(s),
if any, may reasonably request to have included therein, including, without limitation, information relating to the “Plan of Distribution” of the Transfer Restricted Securities, information with respect to the principal amount of Transfer
Restricted Securities being sold to such underwriter(s), the purchase price being paid therefor and any other terms of the offering of the Transfer Restricted Securities to be sold in such offering; and make all required filings of such Prospectus
supplement or post-effective amendment as soon as practicable after the Company is notified of the matters to be incorporated in such Prospectus supplement or post-effective amendment; 

(vii) in the case of a Shelf Registration Statement, upon written request, furnish to each Initial Purchaser, each selling
Holder and each of the underwriter(s), if any, without charge, at least one copy of the Shelf Registration Statement, as first filed with the Commission, and of each amendment thereto, including financial statements and schedules, all documents
incorporated by reference therein and all exhibits (including exhibits incorporated therein by reference); 

(viii) deliver to each selling Holder and each of the underwriter(s), if any, without charge, as many copies of the
Prospectus (including each preliminary prospectus) and any amendment or supplement thereto as such Persons reasonably may request; the Company hereby consents to the use of the Prospectus and any amendment or supplement thereto by each of the
selling Holders and each of the underwriter(s), if any, in connection with the offering and the sale of the Transfer Restricted Securities covered by the Prospectus or any amendment or supplement thereto in accordance with all applicable laws;

 (ix) in the case of a Shelf Registration Statement, enter into such customary agreements (including an
underwriting agreement), and make such customary representations and warranties, and take all such other reasonable actions in connection therewith in 

  
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order to expedite or facilitate the disposition of the Transfer Restricted Securities pursuant to any such Shelf Registration Statement contemplated by this Agreement, all to such extent as may
be requested by any Initial Purchaser or by any Holder of Transfer Restricted Securities or underwriter in connection with any sale or resale pursuant to any Registration Statement contemplated by this Agreement; and whether or not an underwriting
agreement is entered into and whether or not the registration is an Underwritten Registration, the Company shall: 
 (A) furnish to each Initial Purchaser, each selling Holder and each underwriter, if any, in such substance and scope as they may request and as are customarily made by issuers to underwriters in primary
underwritten offerings, upon the date of the Consummation of the Exchange Offer or, if applicable, the effectiveness of the Shelf Registration Statement: 
 (1) a certificate, dated the date of Consummation of the Exchange Offer or the date of effectiveness of the Shelf Registration Statement, as the case may be, signed by an officer of the Company who has
specific knowledge of the Company’s financial matters and is satisfactory to the Representatives, confirming, as of the date thereof, the matters set forth in paragraphs (i), (ii) and (iii) of Section 8(d) of the Purchase
Agreement and (but with respect to the Exchange Offer Registration Statement and Shelf Registration Statement, as the case may be) such other matters as such parties may reasonably request; 

(2) in the case of an underwritten offering under a Shelf Registration Statement, an opinion and negative assurance
letter, dated the date of effectiveness of the Shelf Registration Statement, of counsel for Company, covering matters substantially similar to those set forth in the opinions delivered pursuant to Sections 5(f) of the Purchase Agreement and such
other matter as such parties may reasonably request; and 
 (3) in the case of an underwritten offering under a
Shelf Registration Statement, a customary comfort letter, dated the date of effectiveness of the Shelf Registration Statement, from the Company’s independent accountants, in the customary form and covering matters of the type customarily
requested to be covered in comfort letters by underwriters in connection with primary underwritten offerings; 

(B) set forth customary indemnification provisions in the underwriting agreement, if any; and 

(C) deliver such other documents and certificates as may be reasonably requested by such parties to evidence compliance
with Section 6(c)(xi)(A) hereof and with any customary conditions contained in the underwriting agreement or other agreement entered into by the Company pursuant to this Section 6(c)(xi), if any. 

  
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 If at any time the representations and warranties of the Company
contemplated in Section 6(c)(xi)(A)(1) hereof cease to be true and correct, the Company shall so advise the Initial Purchasers and the underwriter(s), if any, and each selling Holder promptly. 

(x) prior to any public offering of Transfer Restricted Securities, reasonably cooperate with the selling Holders, the
underwriter(s), if any, and their respective counsel in connection with the registration and qualification of the Transfer Restricted Securities under the state securities or blue sky laws of such jurisdictions as the selling Holders or
underwriter(s), if any, may reasonably request and do any and all other reasonable acts or things necessary or advisable to enable the disposition in such jurisdictions of the Transfer Restricted Securities covered by the Shelf Registration
Statement; provided, however, that the Company shall not be required to register or qualify as a foreign corporation or other entity where it is not then so qualified or to take any action that would subject it to the service of process in
suits or to taxation, other than as to matters and transactions relating to the Registration Statement, in any jurisdiction where it is not then so subject; 
 (xi) cooperate with the selling Holders and the underwriter(s), if any, to facilitate the timely preparation and delivery of certificates representing Transfer Restricted Securities to be sold under a
Shelf Registration Statement and not bearing any restrictive legends; and enable such Transfer Restricted Securities to be in such denominations and registered in such names as the Holders or the underwriter(s), if any, may request at least two
Business Days prior to any sale of Transfer Restricted Securities made by such Holders or underwriter(s); 

(xii) if any fact or event contemplated by Section 6(c)(iii)(D) hereof shall exist or have occurred, prepare a
supplement or post-effective amendment to the Registration Statement or related Prospectus or any document incorporated therein by reference or file any other required document so that, as thereafter delivered to the purchasers of Transfer
Restricted Securities, the Prospectus will not contain an untrue statement of a material fact or omit to state any material fact necessary in order to make the statements therein not misleading; 

(xiii) provide a CUSIP number for all Securities not later than the effective date of the Registration Statement covering
such Securities and provide the Trustee under the Indenture with printed certificates for such Securities which are in a form eligible for deposit with the Depository Trust Company and take all other action necessary to ensure that all such
Securities are eligible for deposit with the Depository Trust Company; 
 (xiv) cooperate and assist in any
filings required to be made with the FINRA and in the performance of any due diligence investigation by any underwriter (including any “qualified independent underwriter”) that is required to be retained in accordance with the rules and
regulations of the FINRA; 
 (xv) otherwise use its commercially reasonable efforts to comply with all applicable
rules and regulations of the Commission, and make generally available to its security holders, as soon as practicable, a consolidated earnings statement meeting the requirements 

  
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of Rule 158 (which need not be audited) for the twelve-month period (A) commencing at the end of any fiscal quarter in which Transfer Restricted Securities are sold to underwriters in a firm
commitment or commercially reasonable efforts Underwritten Offering or (B) if not sold to underwriters in such an offering, beginning with the first month of the Company’s first fiscal quarter commencing after the effective date of the
Registration Statement; 
 (xvi) cause the Indenture to be qualified under the Trust Indenture Act not later than
the effective date of the first Registration Statement required by this Agreement, and, in connection therewith, cooperate with the Trustee and the Holders of Securities to effect such changes to the Indenture as may be required for such Indenture
to be so qualified in accordance with the terms of the Trust Indenture Act; and to execute and use its commercially reasonable efforts to cause the Trustee to execute, all documents that may be required to effect such changes and all other forms and
documents required to be filed with the Commission to enable such Indenture to be so qualified in a timely manner; and 
 (xvii) if not otherwise available on the Commission’s EDGAR system, provide promptly to each Holder upon written request each document filed with the Commission pursuant to the requirements of
Section 13 and Section 15 of the Exchange Act. 
 Each Holder agrees by acquisition of a Transfer Restricted Security
that, upon receipt of any notice from the Company of the existence of any fact of the kind described in Section 6(c)(iii)(D) hereof, such Holder will forthwith discontinue disposition of Transfer Restricted Securities pursuant to the applicable
Registration Statement until such Holder’s receipt of the copies of the supplemented or amended Prospectus contemplated by Section 6(c)(xvi) hereof, or until it is advised in writing (the “Advice”) by the Company that the use of
the Prospectus may be resumed, and has received copies of any additional or supplemental filings that are incorporated by reference in the Prospectus. If so directed by the Company, each Holder will deliver to the Company (at the Company’s
expense) all copies, other than permanent file copies then in such Holder’s possession, of the Prospectus covering such Transfer Restricted Securities that was current at the time of receipt of such notice. In the event the Company shall give
any such notice, the time period regarding the effectiveness of such Registration Statement set forth in Section 3 or 4 hereof, as applicable, shall be extended by the number of days during the period from and including the date of the giving
of such notice pursuant to Section 6(c)(iii)(D) hereof to and including the date when each selling Holder covered by such Registration Statement shall have received the copies of the supplemented or amended Prospectus contemplated by
Section 6(c)(xvi) hereof or shall have received the Advice; provided, however, that no such extension shall be taken into account in determining whether Additional Interest is due pursuant to Section 5 hereof or the amount of such
Additional Interest, it being agreed that the Company’s option to suspend use of a Registration Statement pursuant to this paragraph shall be treated as a Registration Default for purposes of Section 5 hereof. 

SECTION 7. Registration Expenses. 
 (a) All expenses incident to the Company’s performance of or compliance with this Agreement will be borne by the Company, regardless of whether a Registration Statement been

  
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declared effective by the Commission, including, without limitation: (i) all registration and filing fees and expenses (including filings made by any Initial Purchaser or Holder with the
FINRA (and, if applicable, the reasonable fees and expenses of any “qualified independent underwriter” and its counsel that may be required by the rules and regulations of the FINRA)); (ii) all fees and expenses of compliance with
federal securities and state securities or blue sky laws; (iii) all expenses of printing (including printing certificates for the Exchange Securities to be issued in the Exchange Offer and printing of Prospectuses), messenger and delivery
services and telephone; (iv) all fees and disbursements of counsel for the Company and, pursuant to and subject to Section 7(b) hereof, the Holders of Transfer Restricted Securities; and (v) all fees and disbursements of independent
certified public accountants of the Company (including the expenses of any special audit and comfort letters required by or incident to such performance). 
 The Company will, in any event, bear its internal expenses (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting duties), the expenses of
any annual audit and the fees and expenses of any Person, including special experts, retained by the Company. 
 (b) In
connection with any Shelf Registration Statement required by this Agreement , the Company will reimburse the Initial Purchasers and the Holders of Transfer Restricted Securities being registered pursuant to the Shelf Registration Statement, as
applicable, for the reasonable fees and disbursements of not more than one counsel, who shall be Davis Polk & Wardwell LLP or such other counsel as may be chosen by the Holders of a majority in principal amount of the Transfer Restricted
Securities for whose benefit such Shelf Registration Statement is being prepared. 
 SECTION 8. Indemnification.

 (a) The Company agrees to indemnify and hold harmless (i) each Holder and (ii) each Person, if any, who controls
(within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act) any Holder (any of the Persons referred to in this clause (ii) being hereinafter referred to as a “controlling person”) and
(iii) the respective affiliates, officers, directors, partners and employees of any Holder (any Person referred to in clause (i), (ii) or (iii) may hereinafter be referred to as an “Indemnified Holder”), to the fullest
extent lawful, from and against any and all losses, claims, damages and liabilities (including, without limitation, and as incurred, reimbursement of all reasonable legal fees and other costs of investigating, preparing, pursuing, settling,
compromising, paying or defending any claim or action, or any investigation or proceeding by any governmental agency or body, commenced or threatened, including the reasonable fees and expenses of counsel to any Indemnified Holder), joint or
several, that arise out of, or are based upon, any untrue statement or alleged untrue statement of a material fact contained in any Registration Statement or Prospectus (or any amendment or supplement thereto), or any omission or alleged omission to
state therein a material fact required to be stated therein or necessary to make the statements therein not misleading, except insofar as such losses, claims, damages or liabilities arise out of, or are based upon, any untrue statement or omission
or alleged untrue statement or omission that is made in reliance upon and in conformity with information relating to any of the Holders furnished in writing to the Company by any of the Holders expressly for

  
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use therein. This indemnity agreement shall be in addition to any liability which the Company may otherwise have. 
 In case any action or proceeding (including any governmental or regulatory investigation or proceeding) shall be brought or asserted against any person in respect of which indemnification may be sought
pursuant to Section 8(a) or 8(b), such person (the “Indemnified Person”) shall promptly notify the person against whom such indemnification may be sought (the “Indemnifying Person”) in writing; provided, however, that
the failure to notify the Indemnifying Person shall not relieve it from any liability that it may have under Section 8(a) or (b) except to the extent that it has been materially prejudiced (through the forfeiture of substantive rights or
defenses) by such failure; and provided, further, that the failure to notify the Indemnifying Person shall not relieve it from any liability that it may have to an Indemnified Person otherwise than under Section 8(a) or (b). If any such
proceeding shall be brought or asserted against an Indemnified Person and it shall have notified the Indemnifying Person thereof, the Indemnifying Person shall retain counsel reasonably satisfactory to the Indemnified Person (who shall not, without
the consent of the Indemnified Person, be counsel to the Indemnifying Person) to represent the Indemnified Person in such proceeding and shall pay the reasonable fees and expenses of such counsel related to such proceeding, as incurred. In any such
proceeding, any Indemnified Person shall have the right to retain its own counsel, but the fees and expenses of such counsel shall be at the expense of such Indemnified Person unless (i) the Indemnifying Person and the Indemnified Person shall
have mutually agreed to the contrary; (ii) the Indemnifying Person has failed within a reasonable time to retain counsel reasonably satisfactory to the Indemnified Person; (iii) the Indemnified Person shall have reasonably concluded that
there may be legal defenses available to it that are different from or in addition to those available to the Indemnifying Person; or (iv) the named parties in any such proceeding (including any impleaded parties) include both the Indemnifying
Person and the Indemnified Person and representation of both parties by the same counsel would be inappropriate due to actual or potential differing interest between them. It is understood and agreed that the Indemnifying Person shall not, in
connection with any proceeding or related proceedings in the same jurisdiction, be liable for the reasonable fees and expenses of more than one separate firm (in addition to any local counsel) for all Indemnified Persons, and that all such fees and
expenses shall be paid or reimbursed as they are incurred. The Indemnifying Person shall not be liable for any settlement of any proceeding effected without its written consent, but if settled with such consent or if there be a final judgment for
the plaintiff, the Indemnifying Person agrees to indemnify each Indemnified Person from and against any loss or liability by reason of such settlement or judgment. Notwithstanding the foregoing sentence, if at any time an Indemnified Person shall
have requested that an Indemnifying Person reimburse the Indemnified Person for fees and expenses of counsel as contemplated by this paragraph, the Indemnifying Person shall be liable for any settlement of any proceeding effected without its written
consent if (i) such settlement is entered into more than 90 days after receipt by the Indemnifying Person of such request and (ii) the Indemnifying Person shall not have reimbursed the Indemnified Person in accordance with such request
prior to the date of such settlement. No Indemnifying Person shall, without the written consent of the Indemnified Person, effect any settlement of any pending or threatened proceeding in respect of which any Indemnified Person is or could have been
a party and indemnification could have been sought hereunder by such Indemnified Person, unless such settlement (x) includes an unconditional release of such Indemnified 

  
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Person, in form and substance reasonably satisfactory to such Indemnified Person, from all liability on claims that are the subject matter of such proceeding and (y) does not include any
statement as to or any admission of fault, culpability or a failure to act by or on behalf of any Indemnified Person. 
 (b)
Each Holder agrees, severally and not jointly, to indemnify and hold harmless the Company and its directors and officers who sign a Registration Statement, and any Person controlling (within the meaning of Section 15 of the Securities Act or
Section 20 of the Exchange Act) the Company, and the respective officers, directors, partners and employees of each such Person, to the same extent as the foregoing indemnity from the Company to each of the Indemnified Holders, but only with
respect to any losses, claims, damages or liabilities that arise out of, or are based upon, any untrue statement or omission or alleged untrue statement or omission that is made in reliance upon and in conformity with information relating to such
Holder furnished in writing to the Company by such Holder expressly for use therein. 
 (c) If the indemnification provided for
in this Section 8 is unavailable to an indemnified party under Section 8(a) or (b) hereof (other than by reason of exceptions provided in those Sections) in respect of any losses, claims, damages or liabilities referred to therein,
then each applicable indemnifying party, in lieu of indemnifying such indemnified party, shall contribute to the amount paid or payable by such indemnified party as a result of such losses, claims, damages or liabilities in such proportion as is
appropriate to reflect the relative benefits received by the Company, on the one hand, and the Holders, on the other hand, from the Initial Placement (which in the case of the Company shall be deemed to be equal to the total net proceeds (before
deducting expenses) to the Company from the Initial Placement), the amount of Additional Interest which did not become payable as a result of the filing of the Registration Statement resulting in such losses, claims, damages or liabilities, and such
Registration Statement, or if such allocation is not permitted by applicable law, the relative fault of the Company, on the one hand, and the Holders, on the other hand, in connection with the statements or omissions which resulted in such losses,
claims, damages or liabilities, as well as any other relevant equitable considerations. The relative fault of the Company on the one hand and of the Indemnified Holder on the other shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company, on the one hand, or the Indemnified Holders, on the other hand, and the parties’
relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The amount paid or payable by a party as a result of the losses, claims, damages and liabilities referred to above shall be deemed to
include, subject to the limitations set forth in the second paragraph of Section 8(a) hereof, any legal or other fees or expenses reasonably incurred by such party in connection with investigating or defending any action or claim. 

The Company and each Holder agree that it would not be just and equitable if contribution pursuant to this Section 8(c) were
determined by pro rata allocation (even if the Holders were treated as one entity for such purpose) or by any other method of allocation which does not take account of the equitable considerations referred to in the immediately preceding paragraph.
The amount paid or payable by an indemnified party as a result of the losses, claims, damages or liabilities referred to in the immediately preceding paragraph shall be deemed to include, subject

  
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to the limitations set forth above, any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any such action or claim.
Notwithstanding the provisions of this Section 8, none of the Holders (and its related Indemnified Holders) shall be required to contribute, in the aggregate, any amount in excess of the amount by which the total discount received by the
Holders with respect to the Initial Securities registered by such Holder on such Registration Statement exceeds the amount of any damages which such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or
omission or alleged omission. No Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent
misrepresentation. The Holders’ obligations to contribute pursuant to this Section 8(c) are several in proportion to the respective principal amount of Initial Securities held by each of the Holders hereunder and not joint. 

SECTION 9. Rule 144A. The Company hereby agrees with each Holder, for so long as any Transfer Restricted Securities remain
outstanding, to make available to any Holder or beneficial owner of Transfer Restricted Securities in connection with any sale thereof and any prospective purchaser of such Transfer Restricted Securities from such Holder or beneficial owner, the
information required by Rule 144A(d)(4) under the Securities Act in order to permit resales of such Transfer Restricted Securities pursuant to Rule 144A under the Securities Act. 

SECTION 10. Participation in Underwritten Registrations. No Holder may participate in any Underwritten Registration hereunder
unless such Holder (a) agrees to sell such Holder’s Transfer Restricted Securities on the basis provided in any underwriting arrangements approved by the Persons entitled hereunder to approve such arrangements and (b) completes and
executes all reasonable questionnaires, powers of attorney, indemnities, underwriting agreements, lock-up letters and other documents required under the terms of such underwriting arrangements. 

SECTION 11. Selection of Underwriters. The Holders of Transfer Restricted Securities covered by the Shelf Registration
Statement who desire to do so may sell such Transfer Restricted Securities in an Underwritten Offering. In any such Underwritten Offering, the investment banker(s) and managing underwriter(s) that will administer such offering will be selected by
the Holders of a majority in aggregate principal amount of the Transfer Restricted Securities included in such offering; provided, however, that such investment banker(s) and managing underwriter(s) must be reasonably satisfactory to the
Company. 
 SECTION 12. Miscellaneous. 
 (a) Remedies. The Company hereby agrees that monetary damages would not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Agreement and hereby
agree to waive the defense in any action for specific performance that a remedy at law would be adequate. 
 (b) No
Inconsistent Agreements. The Company will not on or after the date of this Agreement enter into any agreement with respect to its securities that is inconsistent with the rights granted to the Holders in this Agreement or otherwise conflicts
with the provisions hereof. The Company has not previously entered into any agreement granting any registration rights 

  
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with respect to its securities to any Person. The rights granted to the Holders hereunder do not in any way conflict with and are not inconsistent with the rights granted to the holders of the
Company’s securities under any agreement in effect on the date hereof. 
 (c) Adjustments Affecting the Securities.
The Company will not take any action, or permit any change to occur, with respect to the Securities that would materially and adversely affect the ability of the Holders to Consummate any Exchange Offer. 

(d) Amendments and Waivers. The provisions of this Agreement may not be amended, modified or supplemented, and waivers or consents
to or departures from the provisions hereof may not be given unless the Company has (i) in the case of Section 5 hereof and this Section 12(d)(i), obtained the written consent of Holders of all outstanding Transfer Restricted
Securities and (ii) in the case of all other provisions hereof, obtained the written consent of Holders of a majority of the outstanding principal amount of Transfer Restricted Securities (excluding any Transfer Restricted Securities held by
the Company or its Affiliates). Notwithstanding the foregoing, a waiver or consent to departure from the provisions hereof that relates exclusively to the rights of Holders whose securities are being tendered pursuant to the Exchange Offer and that
does not affect directly or indirectly the rights of other Holders whose securities are not being tendered pursuant to such Exchange Offer may be given by the Holders of a majority of the outstanding principal amount of Transfer Restricted
Securities being tendered or registered; provided, however, that, with respect to any matter that directly or indirectly affects the rights of any Initial Purchaser hereunder, the Company shall obtain the written consent of each such Initial
Purchaser with respect to which such amendment, qualification, supplement, waiver, consent or departure is to be effective. 

(e) Notices. All notices and other communications provided for or permitted hereunder shall be made in writing by hand-delivery,
first-class mail (registered or certified, return receipt requested), telex, telecopier, or air courier guaranteeing overnight delivery: 
 (i) if to a Holder, at the address set forth on the records of the Security Registrar under the Indenture, with a copy to the Security Registrar under the Indenture; and 

(ii) if to the Company: 
 Zoetis Inc. 
 c/o Pfizer Inc. 

5 Giralda Farms 
 Madison, New Jersey 07940 
 Fax No.: (646) 563-9617

 Attention: General Counsel 

With a copy to: 
 Skadden, Arps, Slate, Meagher & Flom LLP 
 Four Times
Square 
 New York, New York 10036 

  
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 Fax No.: (212) 735-2000 

Attention: Stacy J. Kanter, Esq. 

                 Dwight S. Yoo, Esq.

 All such notices and communications shall be deemed to have been duly given: at the time delivered by hand, if personally
delivered; five Business Days after being deposited in the mail, postage prepaid, if mailed; when answered back, if telexed; when receipt acknowledged, if telecopied; and on the next Business Day, if timely delivered to an air courier guaranteeing
overnight delivery. 
 Copies of all such notices, demands or other communications shall be concurrently delivered by the Person
giving the same to the Trustee at the address specified in the Indenture. 
 (f) Successors and Assigns. This Agreement
shall inure to the benefit of and be binding upon the successors and assigns of each of the parties, including, without limitation, and without the need for an express assignment, subsequent Holders of Transfer Restricted Securities; provided,
however, that this Agreement shall not inure to the benefit of or be binding upon a successor or assign of a Holder unless and to the extent such successor or assign acquired Transfer Restricted Securities from such Holder. 

(g) Counterparts. This Agreement may be executed in any number of counterparts and by the parties hereto in separate counterparts,
each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. 
 (h) Headings. The headings in this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof. 

(i) Governing Law. THIS AGREEMENT AND ANY CLAIM, CONTROVERSY OR DISPUTE RELATING TO OR ARISING OUT OF THIS AGREEMENT SHALL BE
GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO THE CONFLICTS OF LAW RULES THEREOF THAT WOULD RESULT IN THE APPLICATION OF ANY LAW OTHER THAN THE LAWS OF THE STATE OF NEW YORK. 

(j) Severability. In the event that any one or more of the provisions contained herein, or the application thereof in any
circumstance, is held invalid, illegal or unenforceable, the validity, legality and enforceability of any such provision in every other respect and of the remaining provisions contained herein shall not be affected or impaired thereby. 

(k) Entire Agreement. This Agreement is intended by the parties as a final expression of their agreement and intended to be a
complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter contained herein. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to
herein with respect to the registration rights granted by the Company with respect to the Transfer 

  
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Restricted Securities. This Agreement supersedes all prior agreements and understandings between the parties with respect to such subject matter. 

  
 -20-

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

					
	ZOETIS INC.
		
	By:	 	 /s/ Heidi C. Chen

		 	Name:	 	Heidi C. Chen
		 	Title:	 	Executive Vice President, General Counsel and Corporate Secretary

  
 -21-

 The foregoing Registration Rights Agreement is hereby confirmed and accepted as of the date
first above written: 
  

					
	 MERRILL LYNCH, PIERCE, FENNER & SMITH
                              
INCORPORATED

	BARCLAYS CAPITAL INC.
	J.P. MORGAN SECURITIES LLC
	 DEUTSCHE BANK SECURITIES INC.,
 as Representatives of the several initial Purchasers

	
	Merrill Lynch, Pierce, Fenner & Smith
	                    Incorporated
		
	By:	 	 /s/ James Probert

		 	Name:	 	James Probert
		 	Title:	 	Managing Director
	
	Barclays Capital Inc.
		
	By:	 	 /s/ Pamela Kendall

		 	Name:	 	Pamela Kendall
		 	Title:	 	Director
	
	J.P. Morgan Securities Inc.
		
	By:	 	 /s/ Maria Sramek

		 	Name:	 	Maria Sramek
		 	Title:	 	Executive Director
	
	Deutsche Bank Securities Inc.
		
	By:	 	 /s/ Jack C. McCabe

		 	Name:	 	Jack C. McCabe
		 	Title:	 	Director
		
	By:	 	 /s/ Ross Levitsky

		 	Name:	 	Ross Levitsky
		 	Title:	 	Managing Director

  
 -22-

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