Document:

================================================================================
                  COMMUNITY ECONOMIC BETTERMENT ACCOUNT (CEBA)
                           "VENTURE PROJECT COMPONENT"
                               ROYALTY AGREEMENT
                                    02-VEN-03
                            BIOFORCE LABORATORY, Inc.
                             Federal ID#: 42-1468500
================================================================================

This Agreement made July 10, 2001, between the Iowa Department of Economic
Development (hereinafter,"IDED"), 200 East Grand, Des Moines, IA 50309, and
BioForce Laboratory, Inc. (hereinafter, "Business"), 2901 South Loop Drive,
Suite 3400, Ames, IA 50010, and City of Ames (hereinafter, "Community"), City
Hall, 515 Clark Avenue, PO Box 811, Ames, IA 50010-0811, acknowledges that the
Business will receive the sum of $100,000 as a financial assistance investment
approved on July 10, 2001, under the Community Economic Betterment Account
(CEBA) "Venture Project Component", (hereinafter "Venture Program"). The amount
above is the maximum amount to be awarded under this Agreement.

1.1   DUE DATES. Payments will be due in equal installments on a semi-annual
      basis. Payment dates will be the first day in June and the first day in
      December of each year until the repayment amount has been obtained. In the
      event the first of the month falls on a Saturday or Sunday, the payment
      will be due the following Monday.

      a)    The first scheduled payment date for BioForce Laboratory, Inc., is
            June 1, 2002.

      b)    The payment amount will be based on the full fiscal year-end
            financial statements, or tax returns, prior to the payment date.

1.2   AMOUNT. Business shall pay the following royalties to IDED:

      a)    A royalty equal to 1 percent of prior-year total gross revenues will
            be due to IDED on an annual basis, paid in equal semi-annual
            payments as described in Article 1.1 of this Agreement, until a
            total repayment amount of $200,000 has been reached.

      b)    If determined and independently verified by IDED that continued
            payments as scheduled threaten the survivability of the Business,
            IDED retains the option to restructure repayment of all or portion
            of the royalty. Factors such as debt service coverage and cash flow
            will be taken into consideration in determining repayment ability.
            Any revision to the payment arrangement must be agreed upon in
            writing by the Business and IDED.

1.3   GROSS REVENUES. For the purpose of this Agreement, gross revenues are
      defined as gross sales less trade discounts and returns.

1.4   ADDITIONAL PAYMENTS. The Business may prepay royalties due to IDED in
      whole or in part, without penalty, at any time during the deferment or
      repayment period. Any partial prepayment shall be applied against the
      amount outstanding and shall not postpone the due date of any subsequent
      payments or change the amount of such installments, unless the Business
      and IDED shall other wise agree in writing.

1.5   NON-PAYMENT. If the Business fails to make a royalty payment when due
      under the terms of this Agreement within thirty (30) days following
      written notice of such overdue payment, the Agreement will be considered
      in default and IDED may issue a Notice of Default as described in Section
      1.14.

1.6   CONDITIONS TO DISBURSEMENT OF FUNDS.

      a)    Business must provide IDED verification of the additional fund
            listed below:

<page>

--------------------------------------------------------------------------------
           SOURCE                       TYPE                      AMOUNT
--------------------------------------------------------------------------------
National Institute of Health            Grant                   1,000,000
--------------------------------------------------------------------------------
          Investors                     Equity                  1,000,000
--------------------------------------------------------------------------------

      b)    Provide IDED with a certified copy of the Business' Articles of
            Incorporation.

      c)    Provide IDED with a Certificate of Incumbency naming the current
            officers and directors of the corporation.

      d)    Provide IDED with a Certificate of Good Standing of the Business.

      e)    The business shall have provided documentation to the Department
            that it has consulted with the area Workforce Development Center and
            JTPA/Promise Jobs Service Delivery Area Office to discuss employment
            services available.

      f)    Businesses generating solid or hazardous waste must either: 1)
            submit a copy of the business' existing in-house plan to reduce the
            amount of waste and safely dispose of the waste based on an in-house
            audit conducted within the past three years; 2) submit an outline of
            a plan to be developed in-house or 3) submit documentation that the
            business has authorized the Iowa Department of Natural Resources or
            Iowa Waste Reduction Center to conduct the audit.

1.7   DOCUMENTATION OF EXPENDITURES. The Business shall furnish, upon request
      from IDED, copies of invoices and related supporting documentation
      verifying expenditure of Venture Program funds as identified in
      "Attachment A" to this Agreement.

1.8   ANNUAL STATEMENTS. IDED requires that the Business will provide annual
      audited financial statements or tax returns on or before sixty days
      following the Business fiscal year end until the royalty due to IDED is
      paid-in-full. In the event that the Business does not provide financial
      information or the required annual audited financial statements or tax
      returns within the sixty day period, IDED may issue a Notice of Default as
      described in section 1.14.

1.9   ACCESS TO RECORDS/INSPECTIONS. The Business shall permit IDED, its
      representatives or the State Auditor to examine, audit and/or copy all of
      the Business books, records and accounts and all other documentation or
      materials related to this Agreement. The Business shall permit IDED
      representatives to visit and inspect business operations at any time
      during the Agreement period.

1.10  USE OF VENTURE PROGRAM FUNDS. The Business shall expend funds received
      under this Agreement for legitimate business expenses and designated
      projects in Venture Program Application 02-VEN-03, and as described in
      "Attachment A" to this Agreement and in compliance with 261 Iowa
      Administrative Code Chapter 53 (CEBA Administrative Rules).

1.11  MAINTAIN BUSINESS IN IOWA. Business shall maintain all its business and
      operating facilities in Iowa. The Business shall provide prompt advance
      notice to IDED of any proposed change in the Business ownership, structure
      or control. In the event the Business relocates outside Iowa or changes
      the Business structure or control without notification to IDED, IDED may
      issue a Notice of Default as described in section 1.14.

1.12  ENFORCEMENT. This Agreement shall remain in full force and effect until
      the full royalty due to IDED is paid-in-full or other arrangements are
      agreed upon between the Business and IDED.

1.13  EVENTS OF DEFAULT. The following shall constitute Events of Default under
      this Agreement:

      a)    Non-compliance, failure by business to comply with any of the terms
            or conditions contained in this Agreement;

      b)    Non-payment, when Business fails to make a payment when due under
            the terms of this Agreement within thirty (30) days of written
            notice of such overdue payment;

      c)    Business changes, if there is material change in the Business
            ownership, structure or control that occurs without the prior
            written disclosure to IDED;

<page>

      d)    Relocation or Abandonment, if there is a relocation or abandonment
            of Business without prior written disclosure to IDED.

1.14  NOTICE OF DEFAULT. The Department shall issue a written notice of default
      providing therein a thirty (30) day period in which the Business shall
      have an opportunity to cure, provided that cure is possible and feasible.

1.15  REMEDIES UPON DEFAULT. Upon the happening of any Event of Default and the
      failure of the Business to cure the default after notice as provided in
      Article 1.14, the Department shall have the right to require immediate
      repayment of the total amount of funds due under this Agreement as defined
      in Article 1.2(a) without presentment, demand, protest, notice of protest,
      notice of intention to accelerate or other notice of any kind, all of
      which are expressly waived by the Business.

1.16  TERMINATION. This Agreement may be terminated upon thirty (30) days
      written notice in the following circumstances:

      a)    By IDED, due to an unremedied event of default by the Business.

      b)    As a result of the termination of reduction of funding to IDED, or
            material alteration of the program. This Agreement may be terminated
            by IDED if funds anticipated for the continuing fulfillment of this
            Agreement are at any time not forthcoming due to nonappropriation, a
            reduction in funding level, termination or material alternation of
            this Agreement's funding source, or change in IDED's statutory
            authorization.

      c)    As a result of IDED forgiveness of repayment of the royalty applying
            the criteria described in section 1.2 of this Agreement.

1.17  INDEMNIFICATION AGAINST LOSS OR DAMAGE. The Business shall indemnify and
      hold harmless IDED, its officers and employees, from and against any and
      all losses resulting directly or indirectly from any misrepresentation,
      breach, nonfulfillment, or noncompliance with any terms of this Agreement
      on the part of the Business, except those losses incurred by IDED
      resulting from willful misconduct or negligence on its or their part.

1.18  ENFORCEMENT EXPENSES. Business shall pay upon demand any and all
      reasonable fees and expenses IDED incurs, including the fees and expenses
      of their attorneys, experts and agents, in connection with the exercise or
      enforcement of any of the rights of IDED under the Agreement.

1.19  GOVERNING LAW. This Agreement shall be interpreted in accordance with the
      law of the State of Iowa, and any action relating to the Agreement shall
      only be commenced in the Iowa District Court for Polk County or the United
      States District Court for the Southern District of Iowa.

1.20  SURVIAVAL OF CONTRACT. If any portion of this Agreement is held to be
      invalid or unenforceable, the remainder shall be valid and enforceable.

BioForce Laboratory, Inc.:                  IDED:

By: /s/ Eric Henderson                      By: /s/ Ken Boyd
    ----------------------------------          --------------------------------
    Dr. Eric Henderson, President/CEO           Ken Boyd, Finance Team Leader
                                                Division of Business Development

Date: 8/28/01                               Date: 9/13/01
      --------------------------------            ------------------------------Contract Number 03-PIAP-04
BioForce Nanosciences
Page 1 of 11

                     IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT

                               PIAP LOAN AGREEMENT

                          PIAP LOAN NUMBER: 03-PIAP-04

                           AWARD DATE: March 14, 2003

                     KIND OF AWARD: Loan and Forgivable Loan

                             AWARD AMOUNT: $250,000

                   AGREEMENT EXPIRATION DATE: February 28,2006

THIS PHYSICAL INFRASTRUCTURE ASSISTANCE PROGRAM ("PIAP") AGREEMENT is made by
and between the IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT, 200 East Grand Avenue,
Des Moines, Iowa 50309 ("Department" or "IDED"), and BioForce Nanosciences, Iowa
State University Research Parkm 2901 South Loup Drive, Suite 3400 Ames, IA 50010
("Business").

      The Department desires to make a $100,000 loan and $150,000 forgivable
loan to the Business and the Business desires to accept this loan and forgivable
loan, all upon the terms and conditions set forth in this Agreement.

      THEREFORE, in consideration of the mutual promises contained in this
Agreement and other good and valuable consideration, it is agreed as follows:

                                    ARTICLE I

                                   DEFINITIONS

      As used in this Agreement, the following terms shall apply:

      1.1 AGREEMENT EXPIRATION DATE. "Agreement Expiration Date" means the date
the Agreement ceases to be in force and effect. The Agreement expires upon the
occurrence of one of the following: a) the Loan is repaid in full or required
part, including accrued interest, court costs and any penalties; b) the
Agreement is terminated by the Department due to any default under Article X; c)
no disbursement of PIAP funds has occurred within the twenty four months
immediately following the Award Date; or d) if the Agreement includes only a
Forgivable Loan, at the Project Completion Date.

      1.2: AWARD DATE. "Award Date" means March 14, 2003.

      1.3 FORGIVABLE LOAN. "Forgivable loan" means an award made by the
Department to the Business for which repayment is eliminated in part or entirely
if the Business satisfies the terms of this Agreement.

      1.4 LOAN. "Loan" means funds advanced by the Department to the Business of
which full repayment is expected.

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 2 of 11

      1.5 LOAN AGREEMENT or AGREEMENT. "Loan Agreement" or "Agreement" means
this document, the Project budget and all of the notes, leases, assignments,
mortgages, and similar documents referred to in this document and all other
instruments or documents executed by the Business or otherwise required in
connection with this document, including but not limited to the following:

            a.    Exhibit "A", "PIAP Application" dated February 27, 2003.
            b.    Exhibit "B", "Promissory Notes" dated June 1, 2004.
            c.    Exhibit "C", "Commitment Letter" dated March 14, 2003.
            d.    Exhibit "D", "Program Description and Budget" dated April
                  2003.

      1.6 PROJECT. "Project" means the detailed description of the work,
services, and other obligations to be performed or accomplished by the Business
as described in the Agreement, Exhibit E - Program Description and Budget, and
the PIAP application approved by the Department.

      1.7 PROJECT COMPLETION DATE. "Project Completion Date" means February 28,
2006 and is the date by which the Project tasks shall have been fully
accomplished.

                                   ARTICLE II

                                     FUNDING

      2.1 FUNDING SOURCE. The source of funding for the Loan is an appropriation
by the State legislature for the PIAP Program established under Iowa Code
Section 15E.175.

      2.2 RECEIPT OF FUNDS. All payments under this Agreement are subject to
receipt by the Department of sufficient State funds for the PIAP program. Any
termination, reduction or delay of PIAP funds to the Department shall, at the
option of the Department, result in the termination, reduction or delay of PIAP
funds to the Business.

      2.3 PRIOR COSTS. No expenditures made prior to the Award Date may be
included as Project costs for the purposes of this Agreement.

      2.4 DISBURSEMENT OF LESS THAN THE TOTAL AWARD AMOUNT. If substantial
progress toward work activities as specified in the Agreement, Exhibit "A",
Exhibit "D" of this Agreement has not been made Within one hundred eighty (180)
days of this Agreement, then the Department shall be under no obligation for
further disbursement. The Business shall be obligated to the extent of Loan
proceeds received prior to that date.

                                   ARTICLE III

                                  TERMS OF LOAN

      3.1 LOAN. The Department agrees to make a Loan in the mount of one hundred
thousand dollars ($100,000). Terms of the loan repayment terms: Interest rate of
Zero percent (0%) for a period of Six (6) years to the Business. One (1) year no
payment followed by FIFTY-NINE (59) equal monthly payments of ONE THOUSAND SIX
HUNDRED SIXTY-SIX and 67/100 Dollars ($1,666.67) and a FINAL PAYMENT of ONE
THOUSAND SIX HUNDRED SIXTY-SIX and 47/1100 ($1,666.47).

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 3 of 11

      3.2 PROMISSORY NOTES. The obligation to repay the Loan portion of this
Agreement, if any, shall be evidenced by a Promissory Note(s) executed by the
Business.

      3.3 OTHER TERMS.

      a). The Loan funds will be used by the Business for lease hold
      improvements at its Aspen Business Park facility.

      b). The Business will invest an additional $1,280,000 in total for tenant
      improvements ($130,000), equipment ($150,000) and working capital
      ($1,000,000).

      c). The Business will have a total of 30 positions at the Ames facility.

      d). An additional $100,000 will be provided to assist the Business.

      3.4 PREPAYMENT. The outstanding principal and accrued interest on this
Loan or any part thereof, may be prepaid in part or in full at any time without
penalty.

      3.5 ACCELERATION UPON DEFAULT. If there is a failure to pay any
installment of principal and interest when due, or only a portion is paid, or in
the event of any other unremedied default under this Loan, the Department may
declare the entire unpaid principal and all accrued interest immediately due and
payable.

                                   ARTICLE IV

                            TERMS OF FORGIVABLE LOAN

      4.1 FORGIVABLE LOAN. The Department agrees to award a Forgivable Loan in
the amount of one hundred fifty thousand dollars ($150,000) to assist in the
financing of the Project.

      4.2 PROMISSORY NOTES. The obligation to repay the Forgivable Loan portion
of this Agreement, if any, shall be evidenced by a Promissory Note(s) executed
by the Business.

      4.3 OTHER TERMS.

      a). The Loan funds will be used by the Business for lease hold
      Improvements at its Aspen Business Park facility.

      b). The Business will invest an additional $1,280,000 in total for tenant
      improvements ($130,000), equipment ($150,000) and working capital
      ($1,000,000).

      c). The Business will have a total of 30 positions at the Ames facility.

      d). An additional $100,000 will be provided to assist the Business.

      4.4 FORGIVABLE LOAN AMORTIZATION. If the award includes a Forgivable loan
the Department will, in its sole discretion, determine if the Business has
satisfied the terms Of this Agreement by the Project Completion Date. If the
Department determines that the Business has satisfied said terms as of the
Project Completion Date, then repayment of the Forgivable loan shall be
permanently waived. Should the Department determine that the Business has not
satisfied the terms of this Agreement, or has operated in a manner substantially
inconsistent with the Application under

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 4 of 11

which the terms of the award was made, the Business maybe required to repay all
or part of the Forgivable loan funds.

                                    ARTICLE V

                       CONDITIONS TO DISBURSEMENT OF FUNDS

Unless and until the following conditions have been satisfied, the Department
shall be under no obligation to disburse to the Business any amounts under this
Agreement:

      5.1 AUTHORITY. The Business shall have submitted the following documents
to the Department:

      a.    Certificate of Good Standing of the Corporation.
      b.    Certified copy of the Articles of Incorporation and By-Laws.
      c.    Certificate of Incumbency naming the current officers and directors
            of the corporation.
      d.    Resolution of the Board of Directors authorizing the corporation's
            execution and delivery of this Loan Agreement and the Note and
            borrowing hereunder, and such other papers as the Department may
            reasonably request; and specifying the officer(s) authorized to
            execute the Loan Agreement and bind the corporation.
      e.    Uniform Commercial Code I filing (with copies) showing any and all
            liens that may exist on Business' assets.
      f.    Submission of the Business owners' names and addresses will be
            submitted by the Business prior to disbursing the Loan portion of
            the Award.
      g.    Documentation of satisfactory credit history of the Business with no
            judgments or unsatisfied liens.

      5.2 LOAN AGREEMENT EXECUTED. The Loan Agreement shall have been properly
executed and, where required, acknowledged.

      5.3 RECORDING. The Business shall have paid the fees necessary to properly
record in the appropriate office of the Recorder of Deeds and/or the Secretary
of State any mortgage, security agreement, financing statement or similar
document required by the Department under the Agreement.

                                   ARTICLE VI

                   REPRESENTATIONS AND WARRANTIES OF BUSINESS

      To induce the Department to make the Loan and/or Forgivable Loan referred
to in this Agreement; the Business represents, covenants and warrants that:

      6.1 AUTHORITY. The Business is a corporation duly organized and validly
existing under the laws of the state of incorporation and is in good standing,
and has complied with all applicable laws of the State of Iowa. The Business is
duly authorized and empowered to execute and deliver the Agreement. All action
on the Business' part, such as appropriate resolution of its Board of Directors
for the execution and delivery of the Agreement, has been effectively taken.

      6.2 FINANCIAL INFORMATION. All financial statements and related materials
concerning the Business and the Project provided to the Department are true and
correct in all material respects

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 5 of 11

and completely and accurately represent the subject mailer thereof as of the
effective date of the statements and related materials, and no material adverse
change has occurred since that date.

      6.3 APPLICATION. The contents of the application/business plan submitted
by the Business to the Department for PIAP funding is a complete and accurate
representation of the Business and the Project as of the date of submission and
there has been no material adverse change in the organization, operation,
business prospects, fixed properties, key personnel or project plan of the
Business since the date the Business submitted its PIAP application to the
Department.

      6.4 CLAIMS AND PROCEEDINGS. There are no actions, lawsuits or proceedings
pending or, to the knowledge of the Business, threatened against the Business
affecting in any manner whatsoever its right to execute the Agreement or the
ability of the Business to make the payments required under the agreement, or to
otherwise comply with the obligations of the Business contained under the
Agreement. There are no actions, lawsuits or proceedings at law or in equity, or
before any governmental or administrative authority pending or, to the knowledge
of the Business, threatened against or affecting the Business or any property or
collateral pledged as security for the Loan.

      6.5 EFFECTIVE DATE. The covenants, warranties and representations of this
Article are made as of the date of this Agreement and shall be deemed to be
renewed and restated by the Business at the time of each advance or request for
disbursement of funds.

                                   ARTICLE VII

                              COVENANTS OF BUSINESS

      7.1 AFFIRMATIVE COVENANTS. Until payment in full of the Loan or until the
Forgivable Loan is forgiven, and satisfaction of terms of this Agreement, the
Business covenants to IDED that:

      (a) PROJECT WORK AND SERVICES. The Business shall complete the work and
services detailed in its PIAP application, Sections 3.3 and 4.3 of this
Agreement, and "Exhibit D" by the Project Completion Date.

      (b) RECORDS AND ACCOUNTS. The Business shall maintain books, records,
documents and other evidence pertaining to all costs and expenses incurred and
revenues received under this Agreement concerning the project, in sufficient
detail to reflect all costs, direct and indirect, of labor, materials,
equipment, supplies, services and other costs and expenses of whatever nature,
for which payment is claimed under this Agreement. The Business shall retain all
records for a period of three (3) years from the Agreement Expiration Date.

      (c) ACCESS TO RECORDS/INSPECTIONS. The Business shall, with reasonable
notice, permit the Department, its representatives or the State Auditor to
examine, audit and/or copy (i) any plans and work details pertaining to the
Project, (ii) all of the Business' books, records and accounts, and (iii) all
other documentation or materials related to this Agreement; the Business shall
provide proper facilities for making such examination and/or inspection.

      (d) USE OF LOAN FUNDS. The Business shall expend funds received under the
Loan and/or Forgivable Loan only for the purposes and activities described in
its PIAP Application, Sections 3.3 and 4.3 of this Agreement. Exhibit "D", and
approved by the Department.

      (e) DOCUMENTATION. The Business shall deliver to the IDED, upon request,
(i) copies of all contracts or agreements relating to the Project, (ii)
invoices, receipts, statements or vouchers relating to the Project, (iii) a list
of all unpaid bills for labor and materials in connection with the

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 6 of 11

Project, (iv) budgets and revisions showing estimated Project costs and funds
required at any given time to complete and pay for the Project, and (v) current
and year-to-date operating statements, including but not limited to a Profit and
Loss and Balance Sheet.

      (f) NOTICE OF PROCEEDINGS. The Business shall promptly notify IDED of the
initiation of any claims, lawsuits, bankruptcy proceedings or other proceedings
brought against the Business which would adversely impact the project,
including, but not limited to, any proceedings to assert or enforce liens
against collateral securing the Loan.

      (g) REPORTS. The Business shall prepare, sign and submit the following
reports to the Department when required:

      1).   Annual financial statements, and more frequent statements if
            required by the Department, including an income, expense, and
            retained earnings statement covering the period having elapsed from
            the date of the last prior submission and a balance sheet which is
            not more than thirty (30) days old. Year-end statements must be
            compiled by a Certified Public Accountant (CPA) and must be received
            by the Department within ninety (90) days following the company's
            fiscal year end.

      (h) NOTICE OF BUSINESS CHANGES. The Business shall provide prompt advance
notice to the Department of any proposed change in the Business ownership,
structure or control which would materially affect the Project.

      (i) NOTICE OF MEETINGS. The Business shall notify the Department at least
ten (10) working days in advance of all Board of Directors and Stockholders
meetings at which the subject matter of this Agreement or Project is proposed to
be discussed. The Business shall provide the Department with copies of the
agenda and minutes of such meetings and expressly agrees that a representative
of the Department has a right to attend any and all such meetings for the
purposes of the discussion of the Project and the Loan and/or Forgivable Loan.

      j) MAINTENANCE OF PROJECT PROPERTY AND INSURANCE. The Business shall
maintain the Project property in good repair and condition, ordinary wear and
tear excepted, and shall not suffer or commit waste or damage upon the Project
property. At the Department's request, the Business shall pay for and maintain
insurance against loss or damage by fire, tornado, and other hazards,
casualties, and contingencies and all risks from time to time included under
"extended coverage" policies. This insurance shall be in an amount not less than
the full insurable value of the Project property. The Business shall name the
Department as a mortgagee and/or an additional loss payee as appropriate and
submit copies of the policies to the Department.

      (k) INDEMNIFICATION. The Business shall indemnify and hold harmless the
Department, its officers and employees, from and against any and all losses,
except those losses incurred by the Department resulting from willful misconduct
or negligence on its or their part.

      (l) PROJECT FEES. The Business shall promptly pay all appraisal, survey,
recording, title, license, permit and other fees and expenses incurred incident
to the Loan/Forgivable Loan.

      (m) INTEREST AND SURPLUS PROCEEDS. The Business shall return all
unexpended Loan/Forgivable Loan proceeds and interest accrued on Loan/Forgivable
Loan proceeds to the Department within thirty (30) days after the Project
Completion Date.

      7.2 NEGATIVE COVENANTS. So long as the Business is indebted to IDED, the
Business shall not, without prior written disclosure to IDED and prior written
consent of IDED (unless IDED prior approval is expressly waived below), directly
or indirectly:

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 7 of 11

      (a) BUSINESS' INTEREST. Assign, waive or transfer any of Business' rights,
powers, duties or obligations under this Agreement.

      (b) PROPERTY/COLLATERAL. Sell, transfer, convey, assign, encumber or
otherwise dispose of any of the real property or other collateral securing the
Loan/Forgivable Loan.

      (c) RESTRICTIONS. Place or permit any restrictions, covenants or any
similar limitations on the real property and/or other collateral securing the
Loan/Forgivable Loan.

      (d) REMOVAL OF COLLATERAL. Remove from the Project site or the State all
or any part of the collateral securing the Loan.

      (e) BUSINESS OWNERSHIP. Materially change the ownership, structure, or
control of the business affecting the Project, including but not limited to,
entering into any merger or consolidation with any person, firm or corporation
or permitting substantial distribution, liquidation or other disposal of
business assets directly associated with the Project. Changes in the business
ownership, structure or control which do not materially affect the Project shall
require forty-five (45) days prior written notice of the Department, but not
written consent of, the Department. The materiality of the change and whether or
not the change affects the Project shall be determined by the Department.

      (f) BUSINESS OPERATION. Materially change the nature of the business being
conducted, or proposed to be conducted, as described in the Business'
application for PIAP funding.

                                  ARTICLE VIII

                                    SECURITY

      8.1 SECURITY INSTRUMENTS. The Business shall execute in favor of the
Department all security agreements, financing statements, mortgages, personal
and/or corporate guarantees (hereafter, "Security Instruments") as required by
the Department. The following Security Instruments shall be executed by the
Business

      a). Blanket Uniform Commercial Code 1 (UCC1) on general business assets.

                                   ARTICLE IX

                               DEFAULT AND REMEDIES

      9.1 EVENTS OF DEFAULT. Each of the following shall constitute an Event of
Default under this Agreement:

      (a) MATERIAL MISREPRESENTATION. If at any time any representation,
warranty or statement made or furnished to the Department by, or on behalf of,
the Business in connection with this Agreement or to induce the Department to
make a loan/Forgivable Loan to the Business shall be determined by the
Department to be incorrect, false, misleading or erroneous in any material
respect when made or furnished and shall not have been remedied to the
Department's satisfaction within thirty (30) days after written notice by the
Department is given to the Business.

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 8 of 11

      (b) NON-PAYMENT. If the Business fails to make a payment when due under
the terms of this Agreement within thirty (30) days following written notice of
such overdue payment is given to the Business by the Department.

      (c) NONCOMPLIANCE. If there is a failure by the Business to comply with
any of the covenants, terms or conditions contained in this Agreement or
Security Instruments executed pursuant to this Agreement.

      (d) CROSS DEFAULT. The Department may elect to terminate this Agreement
and demand repayment of PIAP funds, up to the full amount of this Agreement, and
levy appropriate penalties if the Business should fail to satisfy obligations
under any state financial assistance program(s) identified below:

                                None Applicable

      (e) PROJECT COMPLETION DATE. If the Project, in the sole judgment of the
Department, is not completed on or before the Project Completion Date.

      (f) BUSINESS CHANGES. If there is a material change in the Business
ownership, structure, or control which occurs without the prior written
disclosure to and if required, written permission of the Department.

      (g) MISSPENDING. If the Business expends Loan/Forgivable Loan proceeds for
purposes not described in the PIAP application or authorized by the Department.

      (h) INSOLVENCY OR BANKRUPTCY If the Business becomes insolvent or
bankrupt, or admits in writing its inability to pay its debts as they mature, or
makes an assignment for the benefit of creditors, or the Business applies for or
consents to the appointment of a trustee or receiver for the Business or for the
major part of its property; or if a trustee or receiver is appointed for the
Business or for all or a substantial part of the assets of the Business and the
order of such appointment is not discharged, vacated or stayed within sixty (60)
days after such appointment; or if bankruptcy, reorganization, arrangement,
insolvency, or liquidation proceedings or other proceedings for relief under any
bankruptcy or similar law or laws for the relief of debtors, are instituted by
or against the Business and, if instituted against the Business, is consented
to, or, if contested by the Business is not dismissed by the adverse parties or
by an order, decree or judgment within sixty (60) days after such institution.

      (i) INSURANCE. If loss, theft, damage or destruction of any substantial
portion of the property of the Business occurs for which there is either no
insurance coverage or for which, in the opinion of the Department, there is
insufficient insurance coverage.

      (j) INSECURITY. If the Department shall deem itself insecure in good faith
and reasonably believes, after consideration of all the facts and circumstances
then existing, that the prospect of payment and satisfaction of the obligations
under this Agreement, or the performance of or observance of the covenants in
this Agreement, or the value of its collateral is or will be materially
impaired.

      9.2 NOTICE OF DEFAULT. The Department shall issue a written notice of
default providing therein a thirty (30) day period in which the Business shall
have an opportunity to cure, provided that cure is possible and feasible.

      9.3 REMEDIES UPON DEFAULT. Upon the happening of any Event of Default, the
Department shall have the right, in addition to any rights and remedies
available to it under any of the

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 9 of 11

Security Instruments, to require immediate repayment of the full amount of funds
disbursed to the Business under the Agreement plus interest without presentment,
demand, protest, notice of protest, notice of intention to accelerate or other
notice of any kind, all of which are expressly waived by the Business.

                                    ARTICLE X

                             DISBURSEMENT PROCEDURES

      10.1 REQUEST FOR REIMBURSEMENT. All disbursements of proceeds shall be
subject to receipt by the Department of requests for disbursement submitted by
the Business. Requests for disbursement shall be in form and content acceptable
to the Department.

                                   ARTICLE XI

                          GENERAL TERMS AND PROVISIONS

      11.1 BINDING EFFECT. This Agreement shall be binding upon and shall inure
to the benefit of the Department and Business and their respective heirs,
successors, legal representatives and assigns. The obligations, covenants,
warranties, acknowledgments, waivers, agreements, terms, provisions and
conditions of this Agreement shall be jointly and severally enforceable against
the parties to this Agreement.

      11.2 COMPLIANCE WITH LAWS AND REGULATIONS. The Business shall comply with
all applicable State and federal laws, rules, ordinances, regulations and
orders.

      11.3 TERMINATION FOR CONVENIENCE, In addition to termination due to an
Event of Default or nonappropriation of PIAP funds, this Agreement may be
terminated in whole, or in part, when the Department and the Business agree that
the continuation of the Project would not produce beneficial results
commensurate with the future disbursement of Loan/Forgivable Loan funds, The
Department and the Business shall agree upon the termination conditions. The
Business shall not incur new obligations after the effective date of the
termination and shall cancel as many outstanding obligations as is reasonably
possible.

      11.4 PROCEDURE UPON TERMINATION. If the Agreement is terminated for
convenience, an Event of Default or nonappropriation of PIAP funds,
disbursements shall be allowed for costs up to the date of termination
determined by the Department to be in compliance with this Agreement. The
Business shall return to the Department all unencumbered Loan/Forgivable Loan
proceeds within one (1) week of receipt of Notice of Termination. Any costs
previously paid by the Department which are subsequently determined to be
unallowable through audit procedures shall be returned to the Department within
thirty (30) days of the disallowance.

      11.5 SURVIVAL OF AGREEMENT. If any portion of this Agreement is held to be
invalid or unenforceable, the remainder shall be valid and enforceable. The
provisions of this Agreement shall survive the execution of all instruments
herein mentioned and shall continue in full force until the Loan is paid in full
and the terms of the Forgivable Loan have been satisfied.

      11.6 GOVERNING LAW. This Agreement and all Security Instruments shall be
interpreted in accordance with the law of the State of Iowa, and any action
relating to the Agreement shall only be commenced in the Iowa District Court for
Polka County or the United States District Court for the Southern District of
Iowa.

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 10 of 11

      11.7 MODIFICATION. Neither this Agreement nor any provision of the
Security Instruments executed in connection with this Agreement may be changed,
waived, discharged or terminated orally, but only by a written document signed
by the party against whom enforcement of the change, waiver, discharge or
termination is sought.

      11.8 NOTICES. Whenever this Agreement requires or permits any notice or
written request by one party to another, it shall be in writing, enclosed in an
envelope, addressed to the party to be notified at the address heretofore stated
(or at such other address as may have been designated by written notice),
properly stamped, sealed and deposited in the United States Mail. Any such
notice given hereunder shall be deemed delivered upon the earlier of actual
receipt or two (2) business days after posting. The Department may rely on the
address of the Business set forth heretofore, as modified from time to time, as
being the address of the Business.

      11.9 INVESTMENT OF LOAN/FORGIVABLE LOAN FUNDS. Temporarily idle
Loan/Forgivable Loan proceeds held by the Business may be invested provided such
investments shall be in accordance with State law, shall be controlled by the
Business, and any interest accrued shall be credited to and expended on the
Project prior to the expenditure of other Loan/Forgivable Loan proceeds. All
proceeds remaining, including accrued interest, after all allowable Project
costs have been paid or obligated shall be returned to the Department within
thirty (30) days after the Project Completion Date.

      11.10 RESOLUTION OF DISAGREEMENT. In the event of any disagreement between
the parties to this Agreement relating to the technical competence of the work
and services being performed and its conformity to the requirements of this
Agreement, the Department shall resolve the disagreement. The decision of the
Department shall be binding on the Business.

      11.11 WAIVERS. No waiver by the Department of any default hereunder shall
operate as a waiver of any other default or of the same default on any future
occasion. No delay on the part of the Department in exercising any right or
remedy hereunder shall operate as a waiver thereof. No single or partial
exercise of any right or remedy by the Department shall preclude future exercise
thereof or the exercise of any other right or remedy.

      11.12 LIMITATION. It is agreed by the Business that the Department shall
not, under any circumstances, be obligated financially under this Agreement
except to disburse funds according to the terms of the Agreement.

      11.13 ENFORCEMENT EXPENSES. The Business shall pay upon demand any and
all reasonable fees and expenses relating to this project of the Department,
including the fees and expenses of their attorneys, experts and agents, in
connection with the exercise or enforcement of any of the rights of the
Department under the Agreement.

      11.14 HEADINGS. The headings in this Agreement are intended solely for
convenience of reference and shall be given no effect in the construction and
interpretation of this Agreement.

      11.15 FINAL AUTHORITY. The Department shall have the final authority to
assess whether the Business has complied with the terms of this Agreement.

      11.16 INTEGRATION. This Agreement contains the entire understanding
between the Business and the Department and any representations that may have
been made before or after the signing of this Agreement, which are not contained
herein, are nonbinding, void and of no effect. None of the parties have relied
on any such prior representation in entering into this Agreement.

<PAGE>

Contract Number 03-PIAP-04
BioForce Nanosciences
Page 11 of 11

      11.17 COUNTERPARTS. This Agreement may be executed in any number of
counterparts, each of which shall be deemed to be an original, but all of which
together shall constitute but one and the same instrument.

      IN WITNESS WHEREOF, the parties have executed this Agreement effective as
of the Award Date first stated.

IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT:

By: /s/ Mike Fastenau
    ----------------------------------------
    Mike Fastenau, Business Services Manager
    Division of Administration

BioForce Nanosciences:

BY: /s/ Laurence Russ
    ----------------------------------------

    Laurence Russ, Pres. & CEO
    ----------------------------------------
    Print Name and Title

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00120-of-00352.parquet"}]]