Document:

Form of Pledge Agreement

 Exhibit 10.18 
 PLEDGE AGREEMENT 
 THIS PLEDGE AGREEMENT, dated as
of November 17, 2010 (this “Agreement”), is made by Accentia Biopharmaceuticals, Inc., a Florida corporation (the “Pledgor”), in favor of the holders (the “Holders” or the
“Pledgees”) of the 8.50% Secured Convertible Debentures Due May 17, 2012 (collectively, the “Debentures”) issued by Pledgor to the Holders. 

W I T N E S S E T H: 
 WHEREAS, the Holders are existing secured creditors of the Pledgor; 
 WHEREAS, pursuant to the Plan, the Pledgor has issued the Debentures and the Warrants to the Holders; and 
 WHEREAS, the Plan provides that Pledgor shall execute and deliver to Pledgees a pledge agreement providing for the pledge to the Pledgees of, and the grant to the Pledgees of a security interest in,
certain shares of common stock, par value $.01 per share, of Biovest International, Inc., a Delaware corporation (“BVTI”), owned by Pledgor, which shares are represented by the certificate listed on Schedule A annexed hereto
(collectively, the “Pledged Shares”). 
 NOW, THEREFORE, in consideration of the promises and
the agreements herein contained, the Pledgor hereby agrees with the Pledgees as follows: 
 SECTION 1.
Definitions. All terms used in this Agreement which are defined in the Debentures or in Article 8 or Article 9 of the Uniform Commercial Code (the “UCC”) currently in effect in the State of New York and which are not
otherwise defined herein shall have the same meanings herein as set forth therein, provided that terms used herein which are defined in the UCC as in effect in the State of New York on the date hereof shall continue to have the same meaning
notwithstanding any replacement or amendment of such statute. 
 SECTION 2. Pledge and Grant of Security
Interest. As collateral security for all of the Obligations (as defined in Section 4 hereof), the Pledgor hereby pledges and assigns to Pledgees, and grants to Pledgees a continuing security interest in, the Pledgor’s right, title and
interest in and to the Pledged Shares, the certificate representing such Pledged Shares, all options and other rights, contractual or otherwise, in respect thereof and all dividends, distributions, cash, instruments, investment property and other
property (including, but not limited to, any stock dividend and any distribution in connection with a stock split) from time to time received, receivable or otherwise distributed in respect of or in exchange for any or all of the Pledged Shares
(collectively, the “Pledged Collateral”). 
 SECTION 3. The Pledged Collateral and the
Agent. 

  

 (a) Delivery of Pledged Collateral. Concurrently
herewith, all certificates representing or evidencing the Pledged Shares, in suitable form for transfer by delivery, or accompanied by instruments of transfer or assignment duly executed in blank, are being deposited with and delivered to
StockTrans, Inc. (the “Agent”), as collateral agent for the Pledgees. Such appointment shall continue until revoked in writing by the Holders in interest of at least 75% or more of the Pledged Shares then held by the Agent (assuming
for such purpose that all Pledged Shares that have not been transferred to a Holder set forth on Schedule A hereto have been transferred to the applicable Holder), at which time the Holders in interest of at least 75% or more of the Pledged
Shares then held by the Agent (assuming for such purpose that all Pledged Shares that have not been transferred to a Holder set forth on Schedule A hereto have been transferred to the applicable Holder) shall appoint a new Agent. The Agent
shall have the right at any time after the occurrence of the matters described in Section 3(b)(i), (ii) or (iii) herein to exchange certificates or instruments representing or evidencing Pledged Collateral for certificates or
instruments of smaller or larger denominations. 
 (b) Release of Pledged Collateral.

 (i) Release Upon Voluntary Exchange of Debentures. Upon receipt of a Notice of Exchange
of the exchange by a Holder of all or part of the Debenture(s) held by such Holder pursuant to Section 4(e) of the Debentures, the Agent shall release, out of the Pledged Collateral to such Holder, such number of Pledged Shares as is set forth
in the Notice of Exchange. 
 (ii) Release Upon Voluntary Exercise of Warrants. Upon
receipt of a Notice of Exercise of the exercise by a Holder of all or part of the Warrant(s) held by such Holder pursuant to Section 2(a) of the Warrants, the Agent shall release, out of the Pledged Collateral to such Holder, such number of
Pledged Shares as is set forth in the Notice of Exercise. 
 (iii) Release Upon an Event of
Default. At any time after a Holder delivers to the Agent a written notice that an Event of Default has occurred pursuant to Section 8 of the Debentures, any Holder may, at its option, deliver written instructions to the Agent (a
“Default Notice”) to release to such Holder such number of Pledged Shares that may be released following an Event of Default as determined by the terms of Section 8(b) of the Debentures. 

(iv) Procedure for Delivery of Pledged Shares. Upon the receipt of a Notice of Exchange, Notice of
Exercise or Default Notice, the Agent shall use its commercially reasonable best efforts to deliver to the applicable Holder the Pledged Shares subject to such notice within three Business Days following receipt of the applicable notice pursuant to
the delivery instructions set forth in such notice. Certificates evidencing the Pledged Shares delivered to the Holder hereunder shall be free and clear of all legends (except that a legend shall be included on any certificates issued during the
ninety (90) day period following November 17, 2010 pursuant to a Notice of Exchange, such legend noting only the lock-up provisions set forth in Article 5.6.1.7 of the Plan) and shall be transmitted by the Agent to the applicable Holder by
crediting the account at such Holder’s prime broker with the Depository Trust Company’s DWAC System, provided the Holder’s bank or prime broker initiates the DWAC transaction. If the DWAC System is not available for the delivery of
the Pledged Shares to the Holder 

  
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hereunder, the Agent shall deliver a certificate for the Pledged Shares registered in the name of the Holder or its designee, via overnight delivery by a common carrier, to the address as
specified in the Notice of Exchange, Notice of Exercise or Default Notice. For clarity, in addition to providing the Agent with a Notice of Exchange, Notice of Exercise and/or Default Notice as contemplated by this Section 3(b) upon an exchange
of the Debentures, an exercise of the Warrants and/or an Event of Default under the Debentures, as applicable, the applicable Holder shall also deliver to the Pledgor such Notice of Exchange, Notice of Exercise and/or Default Notice, as applicable,
pursuant to the requirements of the Debentures and/or the Warrants. 
 (v) Maximum Number of
Pledged Shares Transferable to a Holder. The maximum number of Pledged Shares transferable to a Holder upon (A) exchange of its Debenture(s), (B) exercise of its Warrant(s) and (C) an Event of Default under the Debentures shall be
as set forth opposite such Holder’s name on Schedule A hereto (such amounts shall be subject to adjustment for forward and reverse stock splits, stock dividends, recapitalizations and the like). Such number shall be reduced on a share
for share basis following the delivery to a Holder of Pledged Shares upon any of the events described in (A), (B) or (C) of the preceding sentence. Each Holder shall be entitled to allocate its portion of the Pledged Shares among the
events described in (A), (B) or (C) in any manner it chooses; provided, however, that a Holder’s allocation of Pledged Shares to the events described in (A) and (C) shall not exceed the maximum number of
Pledged Shares transferable to such Holder under Notice(s) of Exchange or Default Notice(s) pursuant to the terms of its Debenture(s). For purposes of clarity, the parties hereto acknowledge and agree that, upon delivery to a Holder of Pledged
Shares pursuant to an exchange of its Debenture(s) or an Event of Default under its Debenture(s), any remaining Pledged Shares allocated to such Holder shall remain pledged under this Agreement in connection with such Holder’s Warrant(s) for
the term of such Warrant(s). 
 (c) The Agent’s Duties. The duties and rights of the
Agent are as set forth on Annex A attached hereto and incorporated herein by reference. Any fees of the Agent for its services hereunder shall be paid by the Pledgor. The fee payable to the Agent hereunder shall be as set forth in
Section 7 of Annex A attached hereto. The powers conferred on the Agent hereunder are solely to protect the interests of the Pledgees in the Pledged Collateral. The Agent and each Pledgee shall be deemed to have exercised reasonable care
in the custody and preservation of any Pledged Collateral in its possession if such Pledged Collateral is accorded treatment substantially equal to that which such party accords its own property. 

SECTION 4. Security for Obligations. The security interest created hereby in the Pledged Collateral constitutes
continuing collateral security for all of the following obligations of the Pledgor to the Holders, whether now existing or hereafter incurred (the “Obligations”): (i) the prompt payment to the Holders, as and when due and
payable (by scheduled maturity, required prepayment, acceleration, demand or otherwise), of all amounts from time to time owing to the Holders in respect of interest, principal and other charges of the Debentures (including, without limitation, all
interest that accrues after the commencement of any case, proceeding or other action relating to bankruptcy, insolvency or reorganization of the Pledgor whether or not the payment of such interest is unenforceable or is not allowable due to the
existence of such case, proceeding or other action) and all fees, commissions, expense reimbursements, indemnifications and all other amounts due or to become due to the Holders under the Debentures and (ii) the

  
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delivery to each Pledgee of its Pledged Shares upon exchange of such Pledgee’s Debenture(s) or an Event of Default on such Pledgee’s Debenture(s) or upon exercise of such Pledgee’s
Warrant(s). 
 SECTION 5. Delivery of the Pledged Collateral. 

(a) The Agent shall hold the Pledged Shares for the benefit of the Pledgees, together with undated stock
powers executed in blank, signature medallion guaranteed by an eligible institution and suitable for transfer, and Pledgor further agrees to execute such other documents and to take such other actions as the Agent or any Pledgee deems reasonably
necessary or desirable to create and perfect the security interests intended to be created hereunder, to effect the foregoing and to permit the Agent and/or any Pledgee to exercise any of their rights and remedies hereunder. 

(b) If Pledgor shall receive, by virtue of its being or having been an owner of any Pledged Collateral,
any (i) stock certificate (including, without limitation, any certificate representing a stock dividend or distribution in connection with any increase or reduction of capital, reclassification, merger, consolidation, sale of assets,
combination of shares, stock split, spin-off or split-off), promissory note or other instrument, (ii) option or right, whether as an addition to, substitution for, or in exchange for, any Pledged Collateral, or otherwise, (iii) dividends
or interest payable in cash or in securities or other property, (iv) dividends, interest and other distributions paid or payable other than in cash in respect of, and instruments and other property received, receivable or otherwise distributed
in respect of or in exchange for, any Pledged Collateral, (v) dividends or other distributions in connection with a partial or total liquidation or dissolution or in connection with a reduction of capital, capital surplus or paid-in surplus, or
(vi) cash paid, payable or otherwise distributed in redemption of, or in exchange for, any Pledged Collateral, such stock certificate, promissory note, instrument, option, right, property, payment or distribution constituting Pledged Collateral
shall be, and shall forthwith be delivered to the Agent for the benefit of the Pledgees to hold as, Pledged Collateral and shall be received in trust for the benefit of the Pledgees, shall be segregated from Pledgor’s other property and shall
be delivered forthwith to Agent in the exact form received, with any necessary endorsement and/or appropriate stock powers duly executed in blank, to be held by the Agent for the benefit of the Pledgees as Pledged Collateral and as further
collateral security for the Obligations. 
 SECTION 6. Representations and Warranties. The Pledgor
represents and warrants as follows: 
 (a) The execution, delivery and performance by the Pledgor
of this Agreement and the exercise by Pledgees of any of their rights and remedies in accordance with the terms of this Agreement and applicable securities law will not contravene any law or any contractual restriction binding on or affecting the
Pledgor or any of its properties and do not and will not result in or require the creation of any lien upon or with respect to any of its properties other than pursuant to this Agreement. 

  
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 (b) The Pledgor is and will be at all times the beneficial
owner of the Pledged Collateral free and clear of any lien or option, except for the security interest created by this Agreement. 
 (c) No authorization or approval or other action by, and no notice to or filing with, any governmental authority or other regulatory body, other than the filing of a Form 4 and an amendment to
Pledgor’s Schedule 13D with the Commission, is required for the grant by the Pledgor, or the perfection, of the security interest purported to be created hereby in the Pledged Collateral or the exercise by the Agent or any Pledgee of any of
their rights and remedies hereunder, except as may be required in connection with any sale of any Pledged Collateral by laws affecting the offering and sale of securities generally, including the foreclosure procedures sanctioned under the
interpretations of the securities laws. 
 (d) This Agreement creates a valid security interest
in favor of the Pledgees in the Pledged Collateral, as security for the Obligations. Such security interest is, or in the case of Pledged Collateral in which the Pledgor obtains rights after the date hereof, will be, a perfected, first priority
security interest. All action necessary to perfect and protect such security interest has been duly taken, except for Agent’s having possession of security certificates constituting Pledged Collateral after the date hereof and obtaining control
of uncertificated securities and security entitlements constituting Pledged Collateral after the date hereof. 

SECTION 7. Covenants as to the Pledged Collateral. So long as any of the Obligations shall remain outstanding, the
Pledgor will, unless the Pledgees shall otherwise consent in writing: 
 (a) keep adequate
records concerning the Pledged Collateral and permit the Agent, any Pledgee or any agents or representatives of the Agent or any Pledgee at any reasonable time and from time to time to examine and make copies of and abstracts from such records;

 (b) at its expense, promptly deliver to the Agent and each Pledgee a copy of each notice or
other communication received by it in respect of the Pledged Collateral; 
 (c) at its expense,
defend Pledgees’ right, title and security interest in and to the Pledged Collateral against the claims of any person or entity; 
 (d) at its expense, at any time and from time to time, promptly execute and deliver all further instruments and documents and take all further action that may be necessary or desirable or that Agent or
any Pledgee may reasonably request in order to (i) perfect and protect the security interest purported to be created hereby, or (ii) enable Agent and each Pledgee to exercise and enforce their rights and remedies hereunder in respect of
the Pledged Collateral; 
 (e) not sell, assign (by operation of law or otherwise), transfer,
exchange or otherwise dispose of any Pledged Collateral or any interest therein; 

  
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 (f) not create or suffer to exist any lien upon or with
respect to any Pledged Collateral except for the security interest created hereby; 
 (g) not
make or consent to any amendment or other modification or waiver with respect to any Pledged Collateral or enter into any agreement or permit to exist any restriction with respect to any Pledged Collateral other than pursuant hereto; and 

(h) not take or fail to take any action which would in any manner impair the value or enforceability of
Pledgee’s security interest in any Pledged Collateral. 
 SECTION 8. Voting Rights, Etc. in Respect of
the Pledged Collateral. 
 (a) So long as no Event of Default or event which, with the giving
of notice or lapse of time or both, would constitute an Event of Default, shall have occurred and be continuing: 
 (i) the Pledgor may exercise any and all voting and other consensual rights pertaining to any Pledged Collateral for any purpose not inconsistent with the terms of the Debentures; and 

(ii) the Agent on behalf of the Pledgees will execute and deliver (or cause to be executed and delivered)
to the Pledgor all such proxies and other instruments as Pledgor may reasonably request for the purpose of enabling Pledgor to exercise the voting and other rights which it is entitled to exercise pursuant to Section 8(a)(i) hereof. 

(b) Upon the occurrence and during the continuance of an Event of Default or an event which, with the
giving of notice or the lapse of time or both, would constitute an Event of Default: 
 (i) all
rights of the Pledgor to exercise the voting and other consensual rights which it would otherwise be entitled to exercise pursuant to Section 8(a)(i) hereof shall cease, and all such rights shall thereupon become vested in the Agent on behalf
of the Pledgees which shall thereupon have the sole right to exercise such voting and other consensual rights; and 
 (ii) without limiting the generality of the foregoing, the Agent, on behalf of the Pledgees, may at its option exercise any and all rights of conversion, exchange, subscription or any other rights,
privileges or options pertaining to any Pledged Collateral as if it were the absolute owner thereof, including, without limitation, the right to exchange, in its discretion, any and all of such Pledged Collateral upon the merger, consolidation,
reorganization, recapitalization or other adjustment of the Pledgor, or upon the exercise of any right, privilege or option pertaining to any Pledged Collateral, and, in connection therewith, to deposit and deliver any and all of the Pledged
Collateral with any committee, depository, transfer agent, registrar or other designated agent upon such terms and conditions as it may determine. 

  
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 SECTION 9. Additional Provisions Concerning the Pledged Collateral.

 (a) The Pledgor hereby authorizes each Pledgee, on behalf of itself, the Agent and the other
Pledgees, to file, without the signature of the Pledgor where permitted by law, one or more financing or continuation statements, and amendments thereto, relating to the Pledged Collateral. However, in no event shall Agent be required to file any
financing or continuation statement, or any amendment thereto, relating to the Pledged Collateral. 
 (b) The Pledgor hereby irrevocably appoints Agent on behalf of the Pledgees as the Pledgor’s attorney-in-fact and proxy, with full authority, exercisable only during the existence of an Event of
Default and exercisable only in accordance with joint written instructions executed by the Pledgees holding at least 75% or more in interest of the Pledged Shares then held by the Agent hereunder (assuming for such purpose that all Pledged Shares
that have not been transferred to a Holder set forth on Schedule A hereto have been transferred to the applicable Holder) (“Pledgee Instructions”), in the place and stead of the Pledgor and in the name of the Pledgor or
otherwise, from time to time, to take any action and to execute any instrument specified in the Pledgee Instructions which the Pledgees may deem necessary or advisable to accomplish the purposes of this Agreement (subject to the rights of the
Pledgor under Section 8(a) hereof), including, without limitation, to receive, endorse and collect all instruments made payable to the Pledgor representing any dividend or other distribution in respect of any of Pledgees’ Pledged
Collateral and to give full discharge for the same. This power is coupled with an interest and is irrevocable until all of the Obligations are satisfied in full. 

(c) If the Pledgor fails to perform any agreement or obligation contained herein, the Agent or any Pledgee
itself may perform, or cause performance of, such agreement or obligation with respect to the Pledged Collateral, and the expenses of the Agent or any Pledgee incurred in connection therewith shall be payable by the Pledgor pursuant to
Section 11 hereof and shall be secured by the Pledged Collateral. 
 SECTION 10. Remedies Upon Event of
Default. If an Event of Default under the Debenture of any Pledgee shall have occurred, the sale of the released Pledged Collateral by the applicable Pledgee shall be the sole means by which such Pledgee shall receive the applicable Mandatory
Default Amount from the Pledgor. If the applicable Mandatory Default Amount exceeds the proceeds of the sale of all of the released Pledged Collateral by such Pledgee, the Pledgor shall not be liable to such Pledgee for any deficiency under the
Debenture. 
 SECTION 11. Indemnity and Expenses. 

(a) The Pledgor agrees to indemnify and hold harmless the Agent, each of the Holders and all of their
respective stockholders, partners, members, officers, directors, employees and direct or indirect investors and any of the foregoing persons’ agents or other representatives (including, without limitation, those retained in connection with the
transactions contemplated by this Agreement) from and against any and all third-party claims, damages, losses, liabilities, obligations, penalties, costs and expenses (including, without limitation, reasonable attorney’s fees and disbursements)
to the extent that they 

  
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arise out of or otherwise result from this Agreement (including, without limitation, enforcement of this Agreement), except, as to any such indemnified person or entity, claims, losses or
liabilities resulting solely and directly from such person or entity’s gross negligence or willful misconduct as determined by a final non-appealable judgment of a court of competent jurisdiction and except to the extent that such claims,
losses or liabilities result from failure of such indemnified person or entities to comply with applicable securities laws. 
 (b) The Pledgor will pay to the Agent and any Pledgee upon demand the amount of any and all costs and expenses, including the fees and disbursements of the Agent or such Pledgee’s counsel and of any
experts and agents, which the Agent or any Pledgee may incur in connection with (i) the custody, preservation, use or operation of, or the sale of, collection from, or other realization upon, any of the Pledged Collateral, (ii) the
exercise or enforcement of any of the rights of the Agent or a Pledgee hereunder or (iii) the failure by Pledgor to perform or observe any of the provisions hereof. 

SECTION 12. Notices. Whenever notice is required to be given under this Agreement, unless otherwise provided
herein, such notice shall be given in accordance with the terms of the Debentures. The address for the delivery of notice to the Agent hereunder shall be as set forth below its signature hereto. 

SECTION 13. Security Interest Absolute. To the extent permitted by law, all rights of the Agent, the Pledgees and
the Pledgor hereunder shall be absolute and unconditional irrespective of: (i) any lack of validity or enforceability of any ancillary agreement or any other agreement or instrument relating thereto, (ii) any change in the time, manner or
place of payment of, or in any other term in respect of, all or any of the Obligations, or any other amendment or waiver of or consent to any departure from any guaranty, for all or any of the Obligations, or (iii) any other circumstance which
might otherwise constitute a defense available to, or a discharge of, the Pledgor in respect of the Obligations. All authorizations and agencies contained herein with respect to any of the Pledged Collateral are irrevocable and powers coupled with
an interest. 
 SECTION 14. Miscellaneous. 

(a) No amendment of any provision of this Agreement shall be effective unless it is in writing and signed
by the Agent, the Pledgor and the Pledgees, and no waiver of any provision of this Agreement, and no consent to any departure by the Pledgor therefrom, shall be effective unless it is in writing and signed by the Pledgees, and then such waiver or
consent shall be effective only in the specific instance and for the specific purpose for which given. 
 (b) No failure on the part of the Agent or any Pledgee to exercise, and no delay in exercising, any right hereunder or under any ancillary agreement shall operate as a waiver thereof; nor shall any single
or partial exercise of any such right preclude any other or further exercise thereof or the exercise of any other right. The rights and remedies of the Pledgees provided herein and in the ancillary agreements are cumulative and are in addition to,
and not exclusive of, any rights or remedies provided by law. The 

  
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rights of the Pledgees under any ancillary agreement against any party thereto are not conditional or contingent on any attempt by a Pledgee to exercise any of its rights under any other document
against such party or against any other person or entity. 
 (c) Any provision of this Agreement
which is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining portions hereof or thereof or affecting the validity or
enforceability of such provision in any other jurisdiction. 
 (d) This Agreement shall create a
continuing security interest in the Pledged Collateral and shall (i) remain in full force and effect until the satisfaction in full or release of the Obligations and (ii) be binding on the Pledgor and its successors and assigns and shall
inure, together with all rights and remedies of the Pledgees hereunder, to the benefit of each Pledgee and its respective successors, transferees and assigns; provided that no such transfer or assignment shall be valid if it is in violation of
applicable securities laws. Without limiting the generality of clause (ii) of the immediately preceding sentence, subject to compliance with the applicable securities laws and applicable provisions of the ancillary agreements, a Pledgee may
assign or otherwise transfer all or any portion of the Debentures, and its rights under the ancillary agreements, including, without limitation, this Agreement, to any other person or entity, and such other person or entity shall thereupon become
vested with all of the benefits in respect thereof granted to such Pledgee herein or otherwise unless such benefit is unavailable due to the status of such transferee or otherwise under applicable law. Upon any such permitted assignment or transfer,
all references in this Agreement to a Pledgee shall mean the assignee of such Pledgee. None of the rights or obligations of the Pledgor hereunder may be assigned or otherwise transferred without the prior written consent of the Agent and the
Pledgees. 
 (e) Upon the receipt from Pledgor and all of the Holders of a written notice stating
that all Obligations have been satisfied in full (it being understood that a Holder shall be deemed to have provided the Agent with such notice if all of the Pledged Shares allocated to such Holder as set forth on Schedule A hereto shall have
been transferred to such Holder pursuant to the terms hereof), the Agent on behalf of the Pledgees will, upon the Pledgor’s request and at the Pledgor’s expense, (A) return to the Pledgor such of the Pledged Collateral as shall not
have been sold or otherwise disposed of, dealt with or applied pursuant to the terms hereof and of the ancillary agreements and (B) execute and deliver to the Pledgor, without recourse, representation or warranty, such documents as the Pledgor
shall reasonably request to evidence such termination. 
 (f) All questions concerning the
construction, validity, enforcement and interpretation of this Agreement shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof.
Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or with any
transaction contemplated hereby or discussed herein, and hereby 

  
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irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court or that such suit, action or
proceeding is improper. Each party hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof to such party at the address in effect for notices to it
under this Agreement or the Debentures and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner
permitted by law. Each party hereto hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this Agreement or the transactions
contemplated hereby. If either party shall commence a proceeding to enforce any provisions of this Agreement, then the prevailing party in such proceeding shall be reimbursed by the other party for its attorneys’ fees and other costs and
expenses incurred with the investigation, preparation and prosecution of such proceeding. 
 (g)
Pledgor has entered into this Agreement with the advice of its own legal counsel. Accordingly, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the
interpretation of this Agreement. 
 IN WITNESS WHEREOF, the Pledgor has caused this Agreement to be executed
and delivered by its officer thereunto duly authorized, as of the date first above written. 
  

			
	Accentia Biopharmaceuticals, Inc.
		
	By:	 	 
	Name:	 	Samuel S. Duffey
	Title:	 	President

  

					
	 AGENT:
  

StockTrans, Inc.

		
	By:	 	 
		 	Name:	 	
		 	Title:	 	

 Address for Notice: 
 44 West Lancaster Avenue 
 Ardmore, Pennsylvania 19003 

Fax No.: (610) 649-7302 

  
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 Schedule A 
 Pledged Shares 
 Certificate No. __ representing 14,400,000 shares of Common
Stock of Biovest International, Inc. 
 Allocation of Pledged Shares 

  
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 ANNEX A 
 to 
 PLEDGE AGREEMENT 

THE AGENT 
 1. Appointment. The Pledgees (all capitalized terms used herein and not otherwise defined shall have the respective meanings provided in the Pledge Agreement to which this Annex A is
attached (the “Agreement”)), by their acceptance of the benefits of the Agreement, hereby designate StockTrans, Inc. as the Agent to act as specified herein and in the Agreement. Pledgees and the Pledgor shall be deemed irrevocably
to authorize the Agent to take such action on their behalf under the provisions of the Agreement and any other instruments and agreements referred to herein or therein and to exercise such powers and to perform such duties hereunder and thereunder
as are specifically delegated to or required of the Agent by the terms hereof and thereof and such other powers as are reasonably incidental thereto. The Agent may perform any of its duties hereunder by or through its agents or employees.

 2. Nature of Duties. The Agent shall have no duties or responsibilities except those expressly
set forth in the Agreement. Neither the Agent nor any of its officers, managers, directors, employees or agents shall be liable for any action taken or omitted by it as such under the Agreement or hereunder or in connection herewith or therewith,
unless caused by its or their gross negligence or willful misconduct. The duties of the Agent shall be mechanical and administrative in nature; the Agent shall not have by reason of the Agreement a fiduciary relationship in respect of the Pledgor or
Pledgees; and nothing in the Agreement, expressed or implied, is intended to or shall be so construed as to impose upon the Agent any obligations in respect of the Agreement except as expressly set forth herein and therein. 

3. Lack of Reliance on the Agent. Independently and without reliance upon the Agent, Pledgees, to the extent they
deem appropriate, have made and shall continue to make (i) their own independent investigation of the financial condition and affairs of Pledgor and its subsidiaries in connection with Pledgees’ investment in the Pledgor, the creation and
continuance of the Obligations and the taking or not taking of any action in connection therewith, and (ii) their own appraisal of the creditworthiness of the Pledgor and its subsidiaries, and of the value of the Pledged Collateral from time to
time, and the Agent shall have no duty or responsibility, either initially or on a continuing basis, to provide Pledgees with any credit, market or other information with respect thereto, whether coming into its possession before any Obligations are
incurred or at any time or times thereafter. The Agent shall not be responsible to Pledgor or Pledgees for any recitals, statements, information, representations or warranties herein or in any document, certificate or other writing delivered in
connection herewith, or for the execution, effectiveness, genuineness, validity, enforceability, perfection, collectibility, priority or sufficiency of the Agreement, or for the financial condition of the Pledgor or the value of any of the Pledged
Collateral, or be required to make any inquiry concerning either the performance or observance of any of the terms, provisions or conditions of the Agreement, or the financial condition of the Pledgor, or the value of any of the Pledged Collateral,
or the existence or possible existence of any default or Event of Default under the Agreement or the Debentures or any related agreement. 

  
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 4. Certain Rights of the Agent. The Agent shall have the right to
take any action with respect to the Pledged Collateral as set forth in the Agreement on behalf of the Pledgees. To the extent practical, the Agent shall request instructions from the Pledgees with respect to any material act or action (including
failure to act) in connection with the Agreement, and shall be entitled to act or refrain from acting in accordance with the unanimous written instructions of Pledgees; if such instructions are not provided despite the Agent’s request therefor,
the Agent shall be entitled to refrain from such act or taking such action, and if such action is taken, shall be entitled, to the extent requested, to appropriate indemnification from the Pledgees in respect of actions to be taken by the Agent; and
the Agent shall not incur liability to any Person by reason of so refraining. Without limiting the foregoing, Pledgees shall have no right of action whatsoever against the Agent as a result of the Agent acting or refraining from acting hereunder in
accordance with the terms of the Agreement, and the Pledgor shall have no right to question or challenge the authority of, or the instructions given to, the Agent pursuant to the foregoing. 

5. Reliance. The Agent shall be entitled to rely, and shall be fully protected in relying, upon any writing,
resolution, notice, statement, certificate, telex, teletype or telecopier message, cablegram, radiogram, order or other document or telephone message signed, sent or made by the proper person or entity, and, with respect to all legal matters
pertaining to the Agreement and its duties thereunder, upon advice of counsel selected by it. 
 6.
Resignation by the Agent. 
 (a) The Agent may resign from the performance of all its functions and duties under
the Agreement at any time by giving 30 days’ prior written notice (as provided in the Agreement) to the Pledgor and the Pledgees. Such resignation shall take effect upon the appointment of a successor Agent pursuant to clauses (b) and
(c) below. 
 (b) Upon any such notice of resignation, the Pledgees in interest of at least 75% or more of the Pledged
Shares then held by the Agent (assuming for such purpose all Pledged Shares that have not been transferred to a Pledgee set forth on Schedule A to the Agreement have been transferred to the applicable Pledgee) shall appoint a successor Agent
hereunder. 
 (c) If a successor Agent shall not have been so appointed within said 30-day period, the Agent shall then appoint
a successor Agent who shall serve as Agent until such time, if any, as the Pledgees appoint a successor Agent as provided above. If a successor Agent has not been appointed within such 30-day period, the Agent may petition any court of competent
jurisdiction or may interplead the Pledgor and the Pledgees in a proceeding for the appointment of a successor Agent, and all fees, including, but not limited to, extraordinary fees associated with the filing of interpleader and expenses associated
therewith, shall be payable by the Pledgor on demand. 
 7. Fees Payable to the Agent. For services
rendered, the Agent shall receive a fee of $7,500 as total compensation, which fee shall be paid by the Pledgor promptly following the signing of the Agreement. 

  
 13Form of Subsidiary Agreement

 Exhibit 10.19 
 SUBSIDIARY GUARANTEE 
 THIS SUBSIDIARY GUARANTEE, dated as
of November 17, 2010 (this “Guarantee”), is made by each of the signatories hereto (together with any other entity that may become a party hereto as provided herein, the “Guarantors”), in favor of the holders
(together with their permitted assigns, the “Holders”) of the 8.50% Secured Convertible Debentures Due May 17, 2012 (collectively, the “Debentures”) of Accentia Biopharmaceuticals, Inc., a Florida corporation
(the “Company”). 
 W I T N E S S E T H: 

WHEREAS, the Holders are existing secured creditors of the Company; 

WHEREAS, pursuant to the Plan (as defined below), the Company has issued the Debentures to the Holders; and 

WHEREAS, the Plan provides that each Guarantor shall execute and deliver to the Holders a guarantee of the obligations of
the Company pursuant to the Debentures. 
 NOW, THEREFORE, in consideration of the extension of credit by the
Holders, each Guarantor hereby agrees with the Holders as follows: 
 1. Definitions. Defined terms not
defined herein shall have the meanings set forth in the Debentures. The words “hereof,” “herein,” “hereto” and “hereunder” and words of similar import when used in this Guarantee shall refer to this Guarantee
as a whole and not to any particular provision of this Guarantee, and Section and Schedule references are to this Guarantee unless otherwise specified. The meanings given to terms defined herein shall be equally applicable to both the singular and
plural forms of such terms. The following terms shall have the following meanings: 

“Bankruptcy Case” means, collectively, the cases of the Company and its Subsidiaries
pending before the Bankruptcy Court under Chapter 11 of the Bankruptcy Code, and jointly administered under Case No. 8:08-bk-17795-KRM. 
 “Bankruptcy Code” means title 11 of the United States Code, 11 U.S.C. §§ 101 et seq. 

“Bankruptcy Court” means the United States Bankruptcy Court for the Middle District of
Florida, Tampa Division. 
 “Guarantee” means this Subsidiary Guarantee, as the
same may be amended, supplemented or otherwise modified from time to time. 

“Lien” means a lien, charge, pledge, security interest, encumbrance, right of first
refusal, preemptive right or other restriction. 

 “Obligations” means, in addition to all
other costs and expenses of collection incurred by the Holders in enforcing any of such Obligations and/or this Guarantee, all of the liabilities and obligations (primary, secondary, direct, contingent, sole, joint or several) due or to become due,
or that are now or may be hereafter contracted or acquired, or owing, of the Company or any Guarantor to the Holders under this Guarantee, the Debentures and any other instruments, agreements or other documents executed and/or delivered in
connection herewith or therewith, in each case, whether now or hereafter existing, voluntary or involuntary, direct or indirect, absolute or contingent, liquidated or unliquidated, whether or not jointly owed with others, and whether or not from
time to time decreased or extinguished and later increased, created or incurred, and all or any portion of such obligations or liabilities that are paid, to the extent all or any part of such payment is avoided or recovered directly or indirectly
from any of the Holders as a preference, fraudulent transfer or otherwise, as such obligations may be amended, supplemented, converted, extended or modified from time to time. Without limiting the generality of the foregoing, the term
“Obligations” shall include, without limitation: (i) principal of and interest on the Debentures and the loans extended pursuant thereto; (ii) any and all other fees, indemnities, costs, obligations and liabilities of the Company
or any Guarantor from time to time under or in connection with this Guarantee, the Debentures and any other instruments, agreements or other documents executed and/or delivered in connection herewith or therewith; and (iii) all amounts
(including but not limited to post-petition interest) in respect of the foregoing that would be payable but for the fact that the obligations to pay such amounts are unenforceable or not allowable due to the existence of a bankruptcy, reorganization
or similar proceeding involving the Company or any Guarantor. 
 “Plan” means
the First Amended Joint Plan of Reorganization of Accentia Biopharmaceuticals, Inc., Analytica International, Inc., TEAMM Pharmaceuticals, Inc., AccentRx, Inc., and Accentia Specialty Pharmacy, Inc. under Chapter 11 of Title 11, United States Code
dated as of August 16, 2010, as modified by the First Modification to First Amended Joint Plan of Reorganization of Accentia Biopharmaceuticals, Inc., Analytica International, Inc., TEAMM Pharmaceuticals, Inc., AccentRx, Inc., and Accentia
Specialty Pharmacy, Inc. under Chapter 11 of Title 11, United States Code dated as of October 25, 2010 and as further modified from time to time, as filed in the Bankruptcy Case. 

“Pledge Agreement” means that certain Pledge Agreement, dated as of November 17,
2010, executed by the Company in favor of the Holders. 
 2. Guarantee. 

(a) Guarantee. 

(i) The Guarantors hereby, jointly and severally, unconditionally and irrevocably, guarantee to the
Holders and their respective successors, indorsees, transferees and assigns, the prompt and complete payment and performance when 

  
 2 

 
due (whether at the stated maturity, by acceleration or otherwise) of the Obligations. 
 (ii) Anything herein or in the Debentures or the Pledge Agreement to the contrary notwithstanding, the maximum liability of each Guarantor hereunder shall in no event exceed the amount which can be
guaranteed by such Guarantor under applicable federal and state laws, including laws relating to the insolvency of debtors, fraudulent conveyance or transfer or laws affecting the rights of creditors generally (after giving effect to the right of
contribution established in Section 2(b)). 
 (iii) Each Guarantor agrees that the
Obligations may at any time and from time to time exceed the amount of the liability of such Guarantor hereunder without impairing the guarantee contained in this Section 2 or affecting the rights and remedies of the Holders hereunder.

 (iv) The guarantee contained in this Section 2 shall remain in full force and effect
until all the Obligations and the obligations of each Guarantor under the guarantee contained in this Section 2 shall have been satisfied by indefeasible payment in full. 

(v) No payment made by the Company, any of the Guarantors, any other guarantor or any other Person (as
defined in the Debentures) or received or collected by the Holders from the Company, any of the Guarantors, any other guarantor or any other Person by virtue of any action or proceeding or any set-off or appropriation or application at any time or
from time to time in reduction of or in payment of the Obligations shall be deemed to modify, reduce, release or otherwise affect the liability of any Guarantor hereunder which shall, notwithstanding any such payment (other than any payment made by
such Guarantor in respect of the Obligations or any payment received or collected from such Guarantor in respect of the Obligations), remain liable for the Obligations up to the maximum liability of such Guarantor hereunder until the Obligations are
indefeasibly paid in full. 
 (vi) Notwithstanding anything to the contrary in this Guarantee,
with respect to any defaulted non-monetary Obligations the specific performance of which by the Guarantors is not reasonably possible, the Guarantors shall only be liable for making the Holders whole on a monetary basis for the Company’s
failure to perform such Obligations in accordance with the Debentures and the Pledge Agreement. 

(b) Right of Contribution. Subject to Section 2(c), each Guarantor hereby agrees that to the
extent that a Guarantor shall have paid more than its proportionate share of any payment made hereunder, such Guarantor shall be entitled to seek and receive contribution from and against any other Guarantor hereunder which has not paid its
proportionate share of such payment. Each Guarantor’s right of contribution shall be 

  
 3 

 
subject to the terms and conditions of Section 2(c). The provisions of this Section 2(b) shall in no respect limit the obligations and liabilities of any Guarantor to the Holders and
each Guarantor shall remain liable to the Holders for the full amount guaranteed by such Guarantor hereunder. 
 (c) No Subrogation. Notwithstanding any payment made by any Guarantor hereunder or any set-off or application of funds of any Guarantor by the Holders, no Guarantor shall be entitled to be
subrogated to any of the rights of the Holders against the Company or any other Guarantor or any collateral security or guarantee or right of offset held by the Holders for the payment of the Obligations, nor shall any Guarantor seek or be entitled
to seek any contribution or reimbursement from the Company or any other Guarantor in respect of payments made by such Guarantor hereunder, until all amounts owing to the Holders by the Company on account of the Obligations are indefeasibly paid in
full. If any amount shall be paid to any Guarantor on account of such subrogation rights at any time when all of the Obligations shall not have been paid in full, such amount shall be held by such Guarantor in trust for the Holders, segregated from
other funds of such Guarantor, and shall, forthwith upon receipt by such Guarantor, be turned over to the Holders in the exact form received by such Guarantor (duly indorsed by such Guarantor to the Holders, if required), to be applied against the
Obligations, whether matured or unmatured, in such order as the Holders may determine. 
 (d)
Amendments, Etc. With Respect to the Obligations. Each Guarantor shall remain obligated hereunder notwithstanding that, without any reservation of rights against any Guarantor and without notice to or further assent by any Guarantor, any
demand for payment of any of the Obligations made by the Holders may be rescinded by the Holders and any of the Obligations continued, and the Obligations, or the liability of any other Person upon or for any part thereof, or any collateral security
or guarantee therefor or right of offset with respect thereto, may, from time to time, in whole or in part, be renewed, extended, amended, modified, accelerated, compromised, waived, surrendered or released by the Holders, and any documents executed
and delivered in connection therewith may be amended, modified, supplemented or terminated, in whole or in part, as the Holders may deem advisable from time to time, and any collateral security, guarantee or right of offset at any time held by the
Holders for the payment of the Obligations may be sold, exchanged, waived, surrendered or released. The Holders shall have no obligation to protect, secure, perfect or insure any Lien at any time held by them as security for the Obligations or for
the guarantee contained in this Section 2 or any property subject thereto. 
 (e)
Guarantee Absolute and Unconditional. Each Guarantor waives any and all notice of the creation, renewal, extension or accrual of any of the Obligations and notice of or proof of reliance by the Holders upon the guarantee contained in this
Section 2 or acceptance of the guarantee contained in this Section 2; the Obligations, and any of them, shall conclusively be deemed to have been created, contracted or incurred, or renewed, extended, amended or waived, in reliance upon
the guarantee contained in this Section 2; and all dealings between the Company and any of the Guarantors, on the one hand, and the Holders, on the other hand, likewise shall be conclusively presumed to

  
 4 

 
have been had or consummated in reliance upon the guarantee contained in this Section 2. Each Guarantor waives, to the extent permitted by law, diligence, presentment, protest, demand for
payment and notice of default or nonpayment to or upon the Company or any of the Guarantors with respect to the Obligations. Each Guarantor understands and agrees that the guarantee contained in this Section 2 shall be construed as a
continuing, absolute and unconditional guarantee of payment and performance without regard to (a) the validity or enforceability of any of the Obligations or any other collateral security therefor or guarantee or right of offset with respect
thereto at any time or from time to time held by the Holders, (b) any defense, set-off or counterclaim (other than a defense of payment or performance or fraud by the Holders) which may at any time be available to or be asserted by the Company
or any other Person against the Holders, or (c) any other circumstance whatsoever (with or without notice to or knowledge of the Company or such Guarantor) which constitutes, or might be construed to constitute, an equitable or legal discharge
of the Company for the Obligations, or of such Guarantor under the guarantee contained in this Section 2, in bankruptcy or in any other instance. When making any demand hereunder or otherwise pursuing its rights and remedies hereunder against
any Guarantor, the Holders may, but shall be under no obligation to, make a similar demand on or otherwise pursue such rights and remedies as they may have against the Company, any other Guarantor or any other Person or against any collateral
security or guarantee for the Obligations or any right of offset with respect thereto, and any failure by the Holders to make any such demand, to pursue such other rights or remedies or to collect any payments from the Company, any other Guarantor
or any other Person or to realize upon any such collateral security or guarantee or to exercise any such right of offset, or any release of the Company, any other Guarantor or any other Person or any such collateral security, guarantee or right of
offset, shall not relieve any Guarantor of any obligation or liability hereunder, and shall not impair or affect the rights and remedies, whether express, implied or available as a matter of law, of the Holders against any Guarantor. For the
purposes hereof, “demand” shall include the commencement and continuance of any legal proceedings. 
 (f) Reinstatement. The guarantee contained in this Section 2 shall continue to be effective, or be reinstated, as the case may be, if at any time payment, or any part thereof, of any of the
Obligations is rescinded or must otherwise be restored or returned by the Holders upon the insolvency, bankruptcy, dissolution, liquidation or reorganization of the Company or any Guarantor, or upon or as a result of the appointment of a receiver,
intervenor or conservator of, or trustee or similar officer for, the Company or any Guarantor or any substantial part of its property, or otherwise, all as though such payments had not been made. 

(g) Payments. Each Guarantor hereby guarantees that payments hereunder will be paid to the Holders
without set-off or counterclaim in U.S. dollars at the address set forth or referred to in the Debentures. 
 3.
Representations and Warranties. Each Guarantor hereby makes the following representations and warranties to the Holders as of the date hereof: 

  
 5 

 (a) Organization and Qualification. The Guarantor is
a corporation, duly incorporated, validly existing and in good standing under the laws of the applicable jurisdiction set forth on Schedule 1 attached hereto, with the requisite corporate power and authority to own and use its properties and
assets and to carry on its business as currently conducted. The Guarantor has no subsidiaries. The Guarantor is duly qualified to do business and is in good standing as a foreign corporation in each jurisdiction in which the nature of the business
conducted or property owned by it makes such qualification necessary, except where the failure to be so qualified or in good standing, as the case may be, could not, individually or in the aggregate, (x) adversely affect the legality, validity
or enforceability of any of this Guarantee in any material respect, (y) have a material adverse effect on the results of operations, assets, prospects, or financial condition of the Guarantor or (z) adversely impair in any material respect
the Guarantor’s ability to perform fully on a timely basis its obligations under this Guarantee (a “Material Adverse Effect”). 

(b) Authorization; Enforcement. The Guarantor has the requisite corporate power and authority to
enter into and to consummate the transactions contemplated by this Guarantee, and otherwise to carry out its obligations hereunder. The execution and delivery of this Guarantee by the Guarantor and the consummation by it of the transactions
contemplated hereby have been duly authorized by all requisite corporate action on the part of the Guarantor. This Guarantee has been duly executed and delivered by the Guarantor and constitutes the valid and binding obligation of the Guarantor
enforceable against the Guarantor in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws relating to, or affecting generally the
enforcement of, creditors’ rights and remedies or by other equitable principles of general application. 
 (c) No Conflicts. The execution, delivery and performance of this Guarantee by the Guarantor and the consummation by the Guarantor of the transactions contemplated hereby do not and will not
(i) conflict with or violate any provision of its Articles of Incorporation or Bylaws or (ii) conflict with, constitute a default (or an event which with notice or lapse of time or both would become a default) under, or give to others any
rights of termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument to which the Guarantor is a party, or (iii) result in a violation of any law, rule, regulation, order, judgment, injunction, decree or
other restriction of any court or governmental authority to which the Guarantor is subject (including Federal and state securities laws and regulations), or by which any material property or asset of the Guarantor is bound or affected, except in the
case of each of clauses (ii) and (iii), such conflicts, defaults, terminations, amendments, accelerations, cancellations and violations as could not, individually or in the aggregate, have or result in a Material Adverse Effect. The business of
the Guarantor is not being conducted in violation of any law, ordinance or regulation of any governmental authority, except for violations which, individually or in the aggregate, do not have a Material Adverse Effect. 

(d) Consents and Approvals. The Guarantor is not required to obtain any consent, waiver,
authorization or order of, or make any filing or registration with, any 

  
 6 

 
court or other federal, state, local, foreign or other governmental authority or other person in connection with the execution, delivery and performance by the Guarantor of this Guarantee.

 4. Covenants. 

(a) Each Guarantor covenants and agrees with the Holders that, from and after the date of this Guarantee
until the Obligations shall have been indefeasibly paid in full, such Guarantor shall take, and/or shall refrain from taking, as the case may be, such commercially reasonable action that is necessary to be taken or not taken, as the case may be, so
that no Event of Default (as defined in the Debentures) is caused by the failure to take such action or to refrain from taking such action by such Guarantor. 

(b) So long as any of the Obligations are outstanding, each Guarantor will not directly or indirectly on
or after the date of this Guarantee: 
 (i) amend its articles of incorporation, bylaws or other
charter documents so as to adversely affect any rights of any Holder; 
 (ii) repay, repurchase
or offer to repay, repurchase or otherwise acquire more than a de minimis number of shares of its securities or debt obligations; 
 (iii) pay cash dividends on any equity securities of the Company; 
 (iv) enter into any transaction with any Affiliate (as defined in the Debentures) of the Guarantor which would be required to be disclosed in any public filing of the Company with the Commission (as
defined in the Debentures), unless such transaction is made on an arm’s-length basis and expressly approved by a majority of the disinterested directors of the Company (even if less than a quorum otherwise required for board approval); or

 (v) enter into any agreement with respect to any of the foregoing. 

5. Miscellaneous. 

(a) Amendments in Writing. None of the terms or provisions of this Guarantee may be waived,
amended, supplemented or otherwise modified except in writing by the Holders. 
 (b)
Notices. All notices, requests and demands to or upon the Holders or any Guarantor hereunder shall be effected in the manner provided for in the Debentures, provided that any such notice, request or demand to or upon any Guarantor shall be
addressed to such Guarantor at its notice address set forth on Schedule 1 attached hereto. 

  
 7 

 (c) No Waiver By Course Of Conduct; Cumulative
Remedies. The Holders shall not by any act (except by a written instrument pursuant to Section 5(a)), delay, indulgence, omission or otherwise be deemed to have waived any right or remedy hereunder or to have acquiesced in any default under
the Debentures or the Pledge Agreement or Event of Default. No failure to exercise, nor any delay in exercising, on the part of the Holders, any right, power or privilege hereunder shall operate as a waiver thereof. No single or partial exercise of
any right, power or privilege hereunder shall preclude any other or further exercise thereof or the exercise of any other right, power or privilege. A waiver by the Holders of any right or remedy hereunder on any one occasion shall not be construed
as a bar to any right or remedy which the Holders would otherwise have on any future occasion. The rights and remedies herein provided are cumulative, may be exercised singly or concurrently and are not exclusive of any other rights or remedies
provided by law. 
 (d) Enforcement Expenses; Indemnification. 

(i) Each Guarantor agrees to pay, or reimburse the Holders for, all costs and expenses incurred by the
Holders in collecting against such Guarantor under the guarantee contained in Section 2 or otherwise enforcing or preserving any rights under this Guarantee, the Debentures and the Pledge Agreement, including, without limitation, the reasonable
fees and disbursements of counsel to the Holders. 
 (ii) Each Guarantor agrees to pay, and to
save the Holders harmless from, any and all liabilities with respect to, or resulting from any delay in paying, any and all stamp, excise, sales or other taxes which may be payable or determined to be payable in connection with any of the
transactions contemplated by this Guarantee. 
 (iii) The agreements in this Section 5(d)
shall survive repayment of the Obligations. 
 (e) Successor and Assigns. This Guarantee
shall be binding upon the successors and assigns of each Guarantor and shall inure to the benefit of the Holders and their respective successors and assigns; provided that no Guarantor may assign, transfer or delegate any of its rights or
obligations under this Guarantee without the prior written consent of the Holders. 
 (f)
Set-Off. Each Guarantor hereby irrevocably authorizes the Holders at any time and from time to time while an Event of Default under the Debentures or the Pledge Agreement shall have occurred and be continuing, without notice to such Guarantor
or any other Guarantor, any such notice being expressly waived by each Guarantor, to set-off and appropriate and apply any and all deposits, credits, indebtedness or claims, in any currency, in each case whether direct or indirect, absolute or
contingent, matured or unmatured, at any time held by or owing to the Holders to or for the credit or the account of such Guarantor, or any part thereof in such amounts as the Holders may elect, against

  
 8 

 
and on account of the obligations and liabilities of such Guarantor to the Holders hereunder and claims of every nature and description of the Holders against such Guarantor, in any currency,
whether arising hereunder, under the Debentures or otherwise, as the Holders may elect, whether or not the Holders have made any demand for payment and although such obligations, liabilities and claims may be contingent or unmatured. The Holders
shall notify such Guarantor promptly of any such set-off and the application made by the Holders of the proceeds thereof, provided that the failure to give such notice shall not affect the validity of such set-off and application. The rights of the
Holders under this Section are in addition to other rights and remedies (including, without limitation, other rights of set-off) which the Holders may have. 

(g) Counterparts. This Guarantee may be executed by one or more of the parties to this Guarantee on
any number of separate counterparts (including by telecopy), and all of said counterparts taken together shall be deemed to constitute one and the same instrument. 

(h) Severability. Any provision of this Guarantee which is prohibited or unenforceable in any
jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction. 
 (i) Section
Headings. The Section headings used in this Guarantee are for convenience of reference only and are not to affect the construction hereof or be taken into consideration in the interpretation hereof. 

(j) Integration. This Guarantee represents the agreement of the Guarantors and the Holders with
respect to the subject matter hereof and thereof, and there are no promises, undertakings, representations or warranties by the Holders relative to the subject matter hereof and thereof not expressly set forth or referred to herein. 

(k) Governing Laws. All questions concerning the construction, validity, enforcement and
interpretation of this Guarantee shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each of the Guarantors agrees that all
proceedings concerning the interpretation, enforcement and defense of the transactions contemplated by this Guarantee (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, partners, members,
employees or agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York, Borough of Manhattan. Each of the Guarantors hereby irrevocably submits to the exclusive jurisdiction of the state and federal
courts sitting in the City of New York, Borough of Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to
assert in any proceeding, any claim that it is not personally subject to the jurisdiction of any such court or that such proceeding is improper. Each party hereto hereby irrevocably waives personal service of process and

  
 9 

 
consents to process being served in any such proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address
in effect for notices to it under this Guarantee and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any
manner permitted by law. Each party hereto hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this Guarantee or the transactions
contemplated hereby. 
 (l) Acknowledgements. Each Guarantor hereby acknowledges that:

 (i) it has been advised by counsel in the negotiation, execution and delivery of this
Guarantee; 
 (ii) the Holders have no fiduciary relationship with or duty to any Guarantor
arising out of or in connection with this Guarantee, the Debentures or the Pledge Agreement, and the relationship between the Guarantors, on the one hand, and the Holders, on the other hand, in connection herewith or therewith is solely that of
debtor and creditor; and 
 (iii) no joint venture is created hereby or by the Debentures or the
Pledge Agreement or otherwise exists by virtue of the transactions contemplated hereby among the Guarantors and the Holders. 
 (m) Additional Guarantors. The Company shall cause each of its subsidiaries formed or acquired on or subsequent to the date hereof to become a Guarantor for all purposes of this Guarantee by
executing and delivering an Assumption Agreement in the form of Annex 1 hereto. 
 (n)
Release of Guarantors. Each Guarantor will be released from all liability hereunder concurrently with the indefeasible repayment in full of all amounts owed under the Debentures. 

(o) WAIVER OF JURY TRIAL. EACH GUARANTOR AND, BY ACCEPTANCE OF THE BENEFITS HEREOF, THE HOLDERS
HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVE TRIAL BY JURY IN ANY LEGAL ACTION OR PROCEEDING RELATING TO THIS GUARANTEE AND FOR ANY COUNTERCLAIM THEREIN. 
 ********************* 
 (Signature Page Follows) 

  
 10 

 IN WITNESS WHEREOF, each of the undersigned has caused this Guarantee to be
duly executed and delivered as of the date first above written. 
  

					
	ANALYTICA INTERNATIONAL, INC.
		
	 By:
	 	 
		 	 Name:
	 	 Samuel S. Duffey

		 	 Title:
	 	 President

	
	TEAMM PHARMACEUTICALS, INC.
		
	 By:
	 	 
		 	 Name:
	 	 Samuel S. Duffey

		 	 Title:
	 	 President

	
	ACKNOWLEDGED AND AGREED TO:
	
	ACCENTIA BIOPHARMACEUTICALS, INC.
		
	 By:
	 	 
		 	 Name:
	 	 Samuel S. Duffey

		 	 Title:
	 	 President

  
 11 

 Schedule 1 

GUARANTORS 
 The following are the names, notice addresses and jurisdiction of incorporation of each Guarantor. 
  

			
	 NAME AND NOTICE ADDRESS
	  	 JURISDICTION OF
 INCORPORATION

	 Analytica International, Inc.
	  	         Florida

	 324 South Hyde Park Dr., Ste. 350
	  	
	 Tampa, Florida 33606
	  	
		
	 TEAMM Pharmaceuticals, Inc.
	  	         Florida

	 324 South Hyde Park Dr., Ste. 350
	  	
	 Tampa, Florida 33606
	  	

  
 12 

 Annex 1 to 
 SUBSIDIARY GUARANTEE 
 ASSUMPTION AGREEMENT, dated as of
                    , 20    , made by
                    , a
                     (the “Additional Guarantor”), with a mailing address of
                    , in favor of the Holders pursuant to the Guarantee referred to below. All capitalized terms not defined herein shall have
the meaning ascribed to them in such Guarantee. 
 W I T N E S S E T H : 

WHEREAS, the Guarantors (other than the Additional Guarantor) have entered into the Subsidiary Guarantee, dated as of
November 17, 2010 (as amended, supplemented or otherwise modified from time to time, the “Guarantee”), in favor of the Holders; 
 WHEREAS, the Guarantee requires the Additional Guarantor to become a party to the Guarantee; and 
 WHEREAS, the Additional Guarantor has agreed to execute and deliver this Assumption Agreement in order to become a party to the Guarantee; 

NOW, THEREFORE, IT IS AGREED: 
 1. Guarantee. By executing and delivering this Assumption Agreement, the Additional Guarantor, as provided in Section 5(m) of the Guarantee, hereby becomes a party to the Guarantee as a
Guarantor thereunder with the same force and effect as if originally named therein as a Guarantor and, without limiting the generality of the foregoing, hereby expressly assumes all obligations and liabilities of a Guarantor thereunder. The
information set forth in this Assumption Agreement is hereby added to the information set forth in Schedule 1 to the Guarantee. The Additional Guarantor hereby represents and warrants that each of the representations and warranties contained
in Section 3 of the Guarantee is true and correct on and as the date hereof as to such Additional Guarantor (after giving effect to this Assumption Agreement) as if made on and as of the date hereof. 

2. Governing Law. THIS ASSUMPTION AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE
WITH, THE LAW OF THE STATE OF NEW YORK. 

  
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 IN WITNESS WHEREOF, the undersigned has caused this Assumption Agreement to
be duly executed and delivered as of the date first above written. 
  

			
	[ADDITIONAL GUARANTOR]
		
	 By:
	 	 
	Name:
	Title:

  
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