Document:

EX-10.1

 Exhibit 10.1 

ZENTALIS PHARMACEUTICALS, LLC 

2017 PROFITS INTEREST PLAN 

Zentalis Pharmaceuticals, LLC, a Delaware limited liability company (including any successor entity thereto which assumes the Plan, the
“Company”), has adopted this Zentalis Pharmaceuticals, LLC 2017 Profits Interest Plan (as amended, modified or supplemented from time to time, the “Plan”), effective December 21, 2017 (the “Effective
Date”), for the benefit of the eligible Directors, Employees and Consultants of the Company and its Affiliates (each such term as defined below). The purpose of the Plan is to provide such eligible Directors, Employees and Consultants with
an opportunity to participate in the Company’s future success by granting them Awards so as to enhance the ability of the Company and its Affiliates to attract and retain individuals of exceptional talent to contribute to the sustained
progress, growth and profitability of the Company and its Affiliates.    This Plan is the “Class B Common Unit Plan” referenced in the LLC Agreement (as defined below). 

Pursuant to the Plan, eligible Directors, Employees and Consultants may be granted Awards of Class B Common Units (as defined below) and
thereby become Members of the Company (to the extent not already Members). The Class B Common Units so issued shall be governed by, and will be subject to, the transfer restrictions and other provisions contained in the Plan, a Profits Interest
Award Agreement to be executed by and between the Company and each such Participant, and the LLC Agreement. 
 ARTICLE I. 

DEFINITIONS 
 Whenever the
following terms are used in the Plan, they shall have the meanings specified below unless the context clearly indicates to the contrary. Any other capitalized terms used in the Plan but not otherwise defined herein shall have their respective
meanings set forth in the LLC Agreement. The masculine pronoun shall include the feminine and neuter and the singular shall include the plural, where the context so indicates. 

1.1.    Administrator. “Administrator” shall have the meaning set forth in
Section 5.1 hereof. 
 1.2.    Affiliate. “Affiliate” shall have the
meaning given to such term in the LLC Agreement. 
 1.3.    Award. “Award” shall mean an
issuance of Class B Common Units under the terms and conditions of the Plan and the applicable Profits Interest Award Agreement. 

1.4.    Board. “Board” shall mean the Board of Directors of the Company. 

1.5.    C-Corporation.
“C-Corporation” shall mean a corporation under subchapter C of the Code. 

1.6.    Capital Contribution. “Capital Contribution” shall have the meaning ascribed to such term
in the LLC Agreement. 

 1.7.    Cause. “Cause,” with respect to any
Participant, shall mean “Cause” as defined in such Participant’s Profits Interest Award Agreement or employment agreement with the Company or an Affiliate, if such an agreement exists and contains a definition of Cause, or, if no such
agreement exists or such agreement does not contain a definition of Cause, then Cause means: (a) the Participant’s unauthorized use or disclosure of confidential information or trade secrets of the Company or its Affiliates or any other
breach of a written agreement between the Participant and the Company or any of its Affiliates, including without limitation a breach of any employment, confidentiality or restrictive covenant agreement; (b) the Participant’s commission of
a felony or commission of any other crime involving dishonesty or moral turpitude under the applicable law; (c) the Participant’s gross negligence or willful misconduct or the Participant’s willful or repeated failure or refusal to
substantially perform his or her assigned duties; (d) any act of fraud, embezzlement, misappropriation or dishonesty committed by the Participant against the Company or any of its Affiliates; or (e) any acts, omissions or statements by a
Participant which the Company reasonably determines to be detrimental or damaging to the reputation, operations, prospects or business relations of the Company or any of its Affiliates. 

1.8.     Change in Control. “Change in Control” means (a) a Deemed Liquidation Event, or
(b) a Company Unit Sale; provided that the following events shall not constitute a “Change in Control”: (i) an initial public offering of any of the Company’s Securities; (ii) a reincorporation of the Company solely to
change its jurisdiction; or (iii) a transaction undertaken for the primary purpose of creating a holding company that will be owned in substantially the same proportion by the persons who held the Company’s Securities immediately before
such transaction. 
 1.9.    Class A Common Unit. “Class A Common Unit” shall
mean have the meaning ascribed to such term in the LLC Agreement. 
 1.10.    Class B Common Unit.
“Class B Common Unit” shall mean have the meaning ascribed to such term in the LLC Agreement. 

1.11.    Code. “Code” shall mean the Internal Revenue Code of 1986, as amended. Any reference
to any specific provision of the Code shall be deemed to refer also to any successor provisions thereto. 

1.12.    Company. “Company” shall mean Zentalis Pharmaceuticals, LLC, a Delaware limited liability
company, and any successor entity thereto which assumes the Plan. 
 1.13.    Company Unit Sale. “Company
Unit Sale” shall have the meaning ascribed to such term in the LLC Agreement. 
 1.14.    Consultant.
“Consultant” shall mean any consultant or advisor if: (a) the consultant or advisor renders bona fide services to the Company or any Affiliate; (b) the services rendered by the consultant or advisor are not in connection
with the offer or sale of Securities in a capital-raising transaction and do not directly or indirectly promote or maintain a market for the Company’s Securities; and (c) the consultant or advisor is a natural Person who has contracted
directly with the Company or any Affiliate to render such services. 

  
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 1.15.    Deemed Liquidation Event. “Deemed Liquidation
Event” shall have the meaning ascribed to such term in the LLC Agreement. 
 1.16.    Director.
“Director” shall have the meaning ascribed to such term in the LLC Agreement. 

1.17.    Employee. “Employee” shall mean any officer or other employee of the Company or any
Affiliate. A Participant shall not cease to be an Employee in the case of transfers between locations of the Company and its Affiliates or between the Company, any Affiliate or any successor. 

1.18.    Equity Restructuring. “Equity Restructuring” shall mean a
non-reciprocal transaction between the Company and its equity holders, including, without limitation, any equity dividend, equity split, spin-off, rights offering,
recapitalization or large, nonrecurring cash dividend or distribution, that (i) affects the Securities of the Company or the unit price of the Company’s Securities and (ii) causes a change in the per unit value of the Class B
Common Units underlying outstanding Awards. 
 1.19.    Exchange Act. “Exchange Act” shall mean
the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder as in effect from time to time. 

1.20.    Fair Market Value. “Fair Market Value” shall mean, as of any given date, the value of a
Class B Common Unit as determined by the Administrator in good faith based on the amount that such Participant would be entitled to receive in respect of such Class B Common Unit under the LLC Agreement in the event of a hypothetical
complete liquidation of the Company as of such date. 
 1.21.    Good Reason. “Good Reason”
shall mean “Good Reason” as defined in such Participant’s Profits Interest Award Agreement or employment agreement with the Company or an Affiliate, if such an agreement exists and contains a definition of Good Reason, or, if no such
agreement exists or such agreement does not contain a definition of Good Reason, then Good Reason means (a) a change in the Participant’s position with the Company (or its subsidiary employing the Participant) that materially reduces the
Participant’s authority, duties or responsibilities, (b) a material diminution in the Participant’s level of base compensation, except in connection with a general reduction in the base compensation of the Company’s personnel
with similar status and responsibilities or (c) a relocation of the Participant’s place of employment by more than 50 miles, provided that such change, reduction or relocation is effected by the Company (or its subsidiary employing the
Participant) without the Participant’s consent. Notwithstanding the foregoing, Good Reason shall only exist if Participant shall have provided the Company with written notice within sixty (60) days of the initial occurrence of any of the
foregoing events or conditions, and the Company or any successor or affiliate fails to eliminate the conditions constituting Good Reason within thirty (30) days after receipt of written notice of such event or condition from Participant.
Participant’s resignation from employment with the Company for “Good Reason” must occur within six (6) months following the initial occurrence of one of the foregoing events or conditions. Notwithstanding the foregoing, if
Participant is a party to a written employment or consulting agreement with the Company (or its subsidiary) in which the term “good reason” is defined, then “Good Reason” shall be as such term is defined in the applicable written
employment or consulting agreement. 

  
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 1.22.    LLC Agreement. “LLC Agreement” shall
mean the Amended and Restated Limited Liability Company Agreement of Zentalis Pharmaceuticals, LLC dated as of December 21, 2017, by and among the Members named therein, as amended and/or restated from time to time. 

1.23.    Member. “Member” shall have the meaning ascribed to such term in the LLC Agreement. 

1.24.    Participant. “Participant” shall mean any Director, Employee or Consultant who is
selected by the Administrator to receive an Award pursuant to the provisions of Section 3.1 hereof, who executes a Profits Interest Award Agreement pursuant to the provisions of Section 3.2 hereof,
and who joins the LLC Agreement as a Member thereunder. 
 1.25.    Person. “Person” shall mean
any individual, partnership, limited partnership, limited liability company, joint venture, trust, corporation, unincorporated organization, association, estate or other entity. 

1.26.    Plan. “Plan” shall mean this Zentalis Pharmaceuticals, LLC 2017 Profits Interest Plan, as
amended, modified or supplemented from time to time. 
 1.27.    Profits Interest Award Agreement.
“Profits Interest Award Agreement” shall mean the Profits Interest Award Agreement pursuant to which Class B Common Units shall be issued to a Participant under the Plan. 

1.28.    Rule 16b-3. “Rule
16b-3” shall mean that certain Rule 16b-3 under the Exchange Act, as such rule may be amended from time to time. 

1.29.     Securities. “Securities” shall mean, as to any Person (a) shares of capital stock,
membership or partnership interests, units or other equity interests in such Person, (b) obligations, evidences of indebtedness or other securities or interests convertible or exchangeable into capital stock, membership or partnership
interests, units or other equity interests in such Person and (c) subscriptions, calls, warrants, options or commitments of any kind or character relating to, or entitling any Person to purchase or otherwise acquire, any capital stock,
membership or partnership interests, units or other equity interests in such Person. 
 1.30.    Securities Act.
“Securities Act” shall mean the Securities Act of 1933, as amended. 
 1.31.    Termination of
Service. “Termination of Service” shall mean: 
 (a)    As to a Consultant, termination for any
reason, including death, disability, resignation, retirement or termination with or without Cause, at any time, of a Participant’s engagement as a Consultant to the Company or any Affiliate, but excluding any termination where the Participant
simultaneously commences or remains in employment or service with the Company or any Affiliate. 

  
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 (b)    As to a Director, termination for any reason, including, without
limitation, a termination by resignation, removal with or without Cause, failure to be elected, death or retirement, of a Participant’s service as a Director, but excluding any termination where the Participant simultaneously commences or
remains in employment or service with the Company or any Affiliate. 
 (c)    As to an Employee, termination for any
reason, including death, disability, resignation, retirement or termination with or without Cause, at any time, of a Participant’s employment with the Company or any Affiliate, but excluding any termination which includes simultaneous
reemployment or continuous employment of the Participant by the Company or any Affiliate. 
 The Administrator, in its absolute discretion,
shall determine the effect of all matters and questions relating to Terminations of Service, including, without limitation, the question of whether a Termination of Service has occurred, whether any Termination of Service resulted from a discharge
for Cause and all questions of whether particular leaves of absence constitute a Termination of Service. For purposes of the Plan, a Participant’s employee-employer relationship or consultancy relationship shall be deemed to be terminated in
the event that the Affiliate employing or contracting with such Participant ceases to remain an Affiliate of the Company following any merger, sale of stock or other corporate transaction or event (including, without limitation, a spin-off). 
 1.32.    Transfer. “Transfer” shall have the
meaning ascribed to such term in the LLC Agreement. 
 ARTICLE II. 

UNITS SUBJECT TO PLAN 

2.1.    Amount of Awards Subject to Plan. The Awards that may be granted under the Plan shall be Class B
Common Units. Subject to the provisions of Section 6.3 hereof, the maximum aggregate number of Class B Common Units which may be issued hereunder shall be equal to the authorized number of Class B Common Units
pursuant to Section 4.1(a)(iv) under the LLC Agreement from time to time. Such Awards may consist, in whole or in part, of authorized but unissued Class B Common Units, Class B Common Units acquired or reacquired in private
transactions or open market purchases, or Class B Common Units otherwise issuable by the Company, or any combination of the foregoing, as determined by the Administrator in its discretion. 

2.2.    Add-back. To the extent that any Award is forfeited by a
Participant, the Class B Common Units subject to such Award that are forfeited shall thereafter be available for the grant of Awards under the Plan. 

  
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 ARTICLE III. 

AWARDS 

3.1.    Awards. 

(a)    The Administrator may from time to time, in its sole and absolute discretion: 

(i)    Select those Directors, Employees or Consultants who will receive Awards; 

(ii)    Determine the purchase price, if any, of the Class B Common Units subject to any Award, and
the form of payment of any such purchase price for the Class B Common Units subject to any Award; 

(iii)    Determine the Threshold Value, vesting terms and conditions of the Class B Common Units, and
the other terms and conditions applicable to any such Award, including provisions for forfeiture and repurchase, consistent with the Plan and with the LLC Agreement; and 

(iv)    Accelerate the vesting of any Award granted hereunder 

(b)    Upon the selection of a Director, Employee or Consultant to receive an Award, the Administrator shall grant such
Award and may impose such terms and conditions on the issuance of such Award as the Administrator deems appropriate; provided, however, that no such terms and conditions may be inconsistent with the terms and conditions of the Plan or the LLC
Agreement, which are hereby incorporated herein by this reference. 
 3.2.    Profits Interest Award Agreement.
An Award shall be issued only pursuant to an Profits Interest Award Agreement, which shall be executed by the selected Director, Employee or Consultant and an authorized representative of the Company and which shall contain such terms and conditions
as the Administrator shall determine, consistent with the Plan and the LLC Agreement. Upon receipt of an Award, a Participant shall, automatically and without further action on his or her part, be deemed to be a party to, signatory of and bound by
the LLC Agreement as a Member. At the Company’s request, such Participant shall execute the LLC Agreement or a joinder or counterpart signature page thereto. All Awards granted under the Plan shall be subject to the terms and conditions of the
LLC Agreement and shall be subject to such additional restrictions as the Administrator shall provide (in the applicable Profits Interest Award Agreement or otherwise), which restrictions may include, without limitation, restrictions concerning
voting rights and transferability and restrictions based on the duration of the Participant’s employment or other service relationship with the Company or any Affiliate, the performance of the Participant, or the performance of the Company or
any Affiliate; provided, however, that, by action taken in its absolute discretion after the Award is granted, the Administrator may, in its sole discretion, on such terms and conditions as it may determine to be appropriate, remove any or
all of the restrictions imposed by the terms of the applicable Profits Interest Award Agreement. 

  
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 3.3.    Eligibility. An Award of Class B Common Units may
only be granted to a Participant for the performance of services to or for the benefit of the Company or any Affiliate: (i) in the Participant’s capacity as a Member, (ii) in anticipation of the Participant becoming a Member, or
(iii) as otherwise determined by the Administrator, consistent with the treatment of the Class B Common Units as “profits interests” within the meaning of the Code and Rev. Proc. 93-27, 1993-2 C.B. 343 and Rev. Proc. 2001-43, 2001-2 C.B. 191. 

3.4.    Rights as Members. Upon the grant of an Award pursuant to the Plan, the Participant shall have, unless
otherwise provided by the Administrator, all the rights and obligations of a Member with respect to said Awards as provided in the Plan and the LLC Agreement, subject to the restrictions in his or her Profits Interest Award Agreement and the LLC
Agreement. As set forth in the LLC Agreement, the Participant shall not, by virtue of holding an Award, have the right to influence or control the management or operation of the Company. 

3.5.    Escrow. The Administrator or such other escrow holder as the Administrator may appoint shall retain
physical custody of each certificate, if any, representing any Class B Common Units issued under an Award until all of the restrictions, if any, imposed under the Profits Interest Award Agreement with respect to the Award evidenced by such
certificate expire or shall have been removed by the Administrator. 
 ARTICLE IV. 

RESTRICTIONS ON AWARDS 

4.1.    Forfeiture of Awards. Unless otherwise determined by the Administrator, upon any Termination of Service of
a Participant, such Participant’s Award and all Class B Common Units subject thereto, to the extent not vested as of the date of such Termination of Service (after taking into account any accelerated vesting that may occur in connection
with such Termination of Service, if any) (and the proportionate amount of the balance of Participant’s Capital Account (as defined in the LLC Agreement) attributable to such Class B Common Units), shall thereupon automatically and without
further action be cancelled and forfeited by the Participant, and the Participant shall have no further right, title or interest in or with respect to such unvested Class B Common Units (or such proportionate amount of Participant’s
Capital Account balance). 
 4.2.    Restrictions on Class B Common Units. In addition to any
applicable transfer restrictions, repurchase rights and other restrictions set forth in the LLC Agreement with respect to the Class B Common Units, the Class B Common Units shall be subject to such restrictions as the Administrator shall
determine in its sole discretion, including, without limitation, transfer restrictions, repurchase rights, requirements that Class B Common Units be transferred in the event of certain transactions, rights of first refusal with respect to
permitted transfers of Class B Common Units, voting agreements, tag-along rights and drag-along rights. Such restrictions may, in the Administrator’s sole discretion, be contained in the applicable
Profits Interest Award Agreement or in such other agreement as the Administrator shall determine, in each case in a form determined by the Administrator in its sole discretion. The issuance of the Class B Common Units shall be conditioned on
the Participant’s consent to such restrictions or the Participant’s entering into such agreement or agreements. 

  
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 4.3.    Legend. In order to enforce the restrictions imposed upon
the Class B Common Units issued pursuant to Awards granted hereunder, the Administrator may cause a legend or legends to be placed on certificates, if any, representing the Class B Common Units that are subject to restrictions under the
Profits Interest Award Agreements, which legend or legends shall make appropriate reference to the conditions imposed thereby. 
 ARTICLE
V. 
 ADMINISTRATION 

5.1.    Administrator. The Plan shall be administered by the Board or such other individual(s) as may be appointed
or designated by the Board from time to time (in such capacity, the “Administrator”).    To the extent permitted by applicable law, the Board may from time to time delegate to a committee of one or more members
of the Board or one or more officers of Company the authority to grant or amend Awards; provided, however, that in no event shall an officer of the Company be delegated the authority to grant Awards to, or amend Awards held by, the following
individuals: (a) individuals who are subject to Section 16 of the Exchange Act with respect to the Company, or (b) officers (or Directors) of the Company to whom authority to grant or amend Awards is authorized or has been delegated
hereunder. Any delegation hereunder shall be subject to the restrictions and limits that the Board specifies at the time of such delegation, and the Board may at any time rescind the authority so delegated or appoint a new delegatee. At all times,
any delegatee appointed under this Section 5.1 shall serve in such capacity at the pleasure of the Board.  

5.2.    Duties and Powers of Administrator. It shall be the duty of the Administrator to conduct the general
administration of the Plan in accordance with its provisions. The Administrator shall have the discretionary power and authority to interpret the Plan and the Profits Interest Award Agreements pursuant to which Awards are issued, and to adopt such
rules for the administration, interpretation, and application of the Plan as are consistent therewith and to interpret, amend or revoke any such rules. Any Award under the Plan need not be the same with respect to each Participant. The Administrator
may correct any defect or supply any omission or reconcile any inconsistency in the Plan or a Profits Interest Award Agreement in such manner and to such extent as the Administrator deems necessary or appropriate. Unless otherwise expressly provided
in the Plan, all designations, determinations, interpretations and other decisions under or with respect to the Plan or any Award shall be within the sole discretion of the Administrator, may be made at any time and shall be final, conclusive and
binding upon all Persons, including the Company, any Affiliate, any Participant and any beneficiary of any Participant. 

5.3.    Majority Rule; Unanimous Written Consent. Except as otherwise provided in the LLC Agreement, the
Administrator shall act by the affirmative vote of a majority of its members in attendance at a meeting at which a quorum is present and voting or by a unanimous written consent or other written instrument signed by all members of the Administrator.

 5.4.    Professional Assistance; Good Faith Actions; Compensation. All expenses and liabilities which members
of the Administrator incur in connection with the administration of the Plan shall be borne by the Company. The Administrator may employ attorneys, consultants, accountants, appraisers, brokers, or other Persons in connection with the administration
of the 

  
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Plan. The Administrator, the Company and the Company’s officers shall be entitled to rely upon the advice, opinions or valuations of any such Persons. All actions taken and all
interpretations and determinations made by the Administrator in good faith shall be final and binding upon all Participants, the Company and all other interested Persons. No members of the Administrator shall be personally liable for any action,
determination or interpretation made in good faith with respect to the Plan, including grant of Awards, and all members of the Administrator shall be fully protected by the Company in respect of any such action, determination or interpretation. The
members of the Administrator shall serve without compensation for their services as representatives of the Administrator. 

5.5.    Financial Statements and Business Information. To the extent required by applicable securities laws and
subject to any limitations contained in the LLC Agreement, each Participant shall receive financial statements and other information relating to the Company, subject to applicable confidentiality obligations, as determined by the Administrator. 

ARTICLE VI. 

MISCELLANEOUS PROVISIONS 

6.1.    Restrictions on Transfer of Class B Common Units. The Class B Common Units issued
to a Participant under an Award shall be subject to the terms of the Profits Interest Award Agreement pursuant to which such Award was issued and the applicable provisions of the Plan and the LLC Agreement, including, without limitation, any
restrictions on Transfer of Class B Common Units set forth in the LLC Agreement. Any transferee of a permitted Transfer, in accordance with the LLC Agreement and approved by the Administrator, of an Award shall take such Award subject to the
terms of the Plan, the Profits Interest Award Agreement pursuant to which such Award was issued, and the LLC Agreement. Upon such Transfer, such transferee shall, automatically and without further action on his or her part, be deemed to be a party
to, signatory of and bound by the LLC Agreement as a Member. Any such transferee must, upon the request of the Company, execute an instrument in form and substance acceptable to the Company agreeing to be bound by the Plan, the Profits Interest
Award Agreement pursuant to which such Award was issued, and the LLC Agreement, and must agree to such other waivers, limitations, and restrictions as the Company may reasonably require. Any Transfer of the Class B Common Units issued under an
Award which is not made in compliance with the Plan, the LLC Agreement and the Profits Interest Award Agreement pursuant to which such Award was issued shall be null and void ab initio and of no force or effect. 

6.2.    Amendment, Suspension or Termination of the Plan. Except as otherwise provided in this
Section 6.2 hereof, the Plan may be wholly or partially amended or otherwise modified, suspended or terminated at any time and from time to time by the Board; provided, however, that any amendment that requires
Member approval under applicable law shall be subject to such approval to the extent required to comply with such law. No amendment, suspension or termination of the Plan shall materially alter or impair any rights or obligations of a Participant
under any outstanding Award theretofore granted without the consent of the affected Participant, unless the Award itself otherwise expressly so provides. No Award may be granted during any period of suspension or after termination of the Plan, and
in no event may any Award be granted under the Plan after the tenth (10th) anniversary of the Effective Date. For the avoidance of doubt, the creation or issuance of additional Awards or
Class B Common Units or 

  
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any other equity interests in the Company (including any amendments to the LLC Agreement necessary to establish the rights and preferences of, and restrictions applicable to, any such Units or
other equity interests) shall not constitute a material impairment of the rights of any Participant under any outstanding Award that would require the Participant’s consent under this Section 6.2. 

6.3.    Changes in Capitalization and Other Corporate Events. 

(a)    (i)    Subject to Section 6.3(a)(ii) below, in the event that the
Administrator determines, in its sole discretion, that any dividend or other distribution (whether in the form of cash, additional Class B Common Units, other Securities, or other property), any Capital Contributions, any Equity Restructuring,
any recapitalization, reclassification, reorganization, change to corporate form, merger, consolidation, split-up, spin-off, combination, repurchase, liquidation,
dissolution, or sale, transfer, exchange or other disposition of all or substantially all of the assets of the Company (including, but not limited to, a Change in Control or conversion into a C-Corporation),
or exchange of Class B Common Units or other Securities of the Company, issuance of warrants or other rights to purchase Class B Common Units or other Securities of the Company, or other similar transaction or event, in any case, affects
the Class B Common Units such that an adjustment is determined by the Administrator to be appropriate in order to prevent the inequitable dilution or enlargement of the benefits or potential benefits intended to be made available under the Plan
or with respect to an Award, then the Administrator may equitably adjust any or all of: 
 (I)    the
number of Class B Common Units or the number and kind of Securities with respect to which Awards may be granted under the Plan (including, but not limited to, adjustments of the limitations in Section 2.1 hereof on the
maximum number and kind of Class B Common Units or Securities which may be issued); 
 (II)    the
number of Class B Common Units or the number and kind of Securities subject to outstanding Awards; and 

(III)    the purchase price, if any, and/or the Threshold Value with respect to any Award. 

(ii)    Notwithstanding the foregoing, if any transaction or event described in
Section 6.3(a)(i) hereof constitutes an Equity Restructuring: 
 (I)    The
number and type of securities subject to each outstanding Award and the purchase price thereof, if applicable, shall be proportionately adjusted. Such adjustments shall be nondiscretionary and final and binding on the affected Participants and the
Company; and 
 (II)    The Administrator shall make such proportionate adjustments, if any, as the
Administrator in its discretion may deem appropriate to reflect such Equity Restructuring with respect to the number and kind of Securities that may be granted under the Plan (including, but not limited to, adjustments of the limitations in
Section 2.1 hereof on the maximum number and kind of Class B Common Units or Securities which may be issued). 

  
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 (b)    In the event of any Change in Control or other transaction or event
described in Section 6.3(a) hereof or any unusual or nonrecurring transactions or events affecting the Company, any Affiliate of the Company, or the financial statements of the Company or any Affiliate, or of changes in
applicable laws, regulations, or accounting principles, the Administrator in its discretion, and on such terms and conditions as it deems appropriate, is hereby authorized to take any one or more of the following actions whenever the Administrator
determines that such action is appropriate in order to prevent the inequitable dilution or enlargement of the benefits or potential benefits intended to be made available under the Plan or with respect to any Award under the Plan, to facilitate such
transactions or events or to give effect to such changes in laws, regulations or principles: 
 (i)    The
Administrator may provide, either by the terms of the agreement or by action taken prior to the occurrence of such transaction or event, for either (A) the purchase of all or any portion of such Award for an amount of cash equal to the amount
that could have been attained upon the realization of the Participant’s rights had such Award (or portion thereof) been fully vested, or (B) the replacement of such Award with other rights or property selected by the Administrator in its
sole discretion, which replacement award may be subject to vesting or the lapsing of restrictions, as applicable, on terms no less favorable to the affected Participant than the terms of the Award for which such replacement award is substituted;

 (ii)    The Administrator may provide, either by the terms of such Award or by action taken prior to the occurrence
of such transaction or event, that upon such event, such Award be assumed by the successor or survivor entity, or a parent or subsidiary thereof, or shall be substituted for by similar awards covering the stock or Securities of the successor or
survivor entity, or a parent or subsidiary thereof, with appropriate adjustments as to the number and kind of Securities subject to such Award and prices thereof; and 

(iii)    The Administrator may make adjustments in the number and type of Class B Common Units (or other Securities
or property) subject to outstanding Awards and/or in the terms and conditions of (including the purchase price, the repurchase price, the vesting schedule and/or Threshold Value), and the criteria included in, outstanding Awards and Awards which may
be granted in the future. 
 (c)    Subject to Section 6.3(b) hereof, the Administrator may,
in its discretion, include such further provisions and limitations in any Award as it may deem equitable and in the best interests of the Company with respect to any transaction or event described in this Section 6.3. For
the avoidance of doubt, the issuance of additional Class B Common Units in the Company shall not, in and of itself, trigger any adjustments pursuant to this Section 6.3. 

6.4.    Section 83(b) Election. Unless otherwise determined by the Administrator in its sole discretion, each
Participant who is granted an Award under the Plan shall be required to make an election under Section 83(b) of the Code with respect to the Class B Common Units subject to such Award, and the grant of such Award shall be conditioned on
the Participant making such Section 83(b) election. 

  
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 6.5.    Tax Withholding. The Company or an Affiliate, as applicable,
may withhold from each Participant’s wages, or require each Participant to pay to such entity, any applicable withholding or employment taxes resulting from the issuance of any Award hereunder, from the vesting or lapse of any restrictions
imposed on such Award, or from the ownership or disposition of any Class B Common Units (in each case, if any). 

6.6.    No Right to Continued Employment or Service. Nothing in the Plan or in any Profits Interest Award Agreement
shall confer upon any Participant any right to continue in the employment or service of the Company or any Affiliate, or shall interfere with or restrict in any way the rights of the Company or any Affiliate, which rights are hereby expressly
reserved, to discharge any Participant at any time for any reason whatsoever, with or without Cause, except to the extent expressly provided otherwise in a written agreement between the Participant and the Company or any of its Affiliates. 

6.7.    Compliance with Laws. The Plan, the granting and vesting of Awards under the Plan, the issuance and
delivery of Class B Common Units pursuant to the Awards, and any payment or distributions of money under the Plan or under the Awards granted hereunder are subject to compliance with all applicable foreign, federal and state laws, rules and
regulations (including, but not limited to, state and federal securities laws and federal margin requirements) and to such approvals by any listing, regulatory or governmental authority as may, in the opinion of counsel for the Company, be necessary
or advisable in connection therewith. Any Securities delivered under the Plan shall be subject to such restrictions, and the Person acquiring such Securities shall, if requested by the Company, provide such assurances and representations to the
Company as the Company may deem necessary or desirable to assure compliance with all applicable legal requirements. To the extent permitted by applicable law, the Plan and any Awards awarded hereunder shall be deemed amended to the extent necessary
to conform to such laws, rules and regulations. 
 6.8.    Headings. Headings are provided herein for convenience
only and are not to serve as a basis for interpretation or construction of the Plan. 
 6.9.    Governing Law.
The Plan and any agreements hereunder shall be administered, interpreted and enforced under the internal laws of the State of Delaware without regard to conflicts of laws thereof. 

6.10.    Section 409A. No Award or Class B Common Unit is intended to constitute or provide for
“nonqualified deferred compensation” within the meaning of Section 409A of the Code. To the extent that the Administrator determines that any Award granted under the Plan is subject to Section 409A of the Code, the Profits
Interest Award Agreement evidencing such Award shall incorporate the terms and conditions required by Section 409A of the Code. Notwithstanding any provision of the Plan to the contrary, in the event that, following the Effective Date, the
Administrator determines that any Award may be subject to Section 409A of the Code and related Department of Treasury guidance (including such Department of Treasury guidance as may be issued after the Effective Date), the Administrator may
adopt such 

  
 12 

 
amendments to the Plan and the applicable Profits Interest Award Agreement or take any other actions (including amendments and actions with retroactive effect), that the Administrator determines
are necessary or appropriate to preserve the intended tax treatment of the Award, including without limitation, actions intended to (a) exempt the Award from Section 409A of the Code and/or preserve the intended tax treatment of the
benefits provided with respect to the Award, or (b) comply with the requirements of Section 409A of the Code and related Department of Treasury guidance; provided, however, that nothing in this Section 6.10
shall create any obligation on the part of the Company or any Affiliate to adopt any such amendment or take any such other action or any liability for any failure to do so. Notwithstanding anything herein to the contrary, in no event shall the
Company or any Affiliate have any obligation to indemnify or otherwise compensate any Participant for any taxes or interest imposed under Section 409A of the Code, or similar provisions of state law. 

  
 13 

 I hereby certify that the foregoing Plan was duly adopted by the Board of Directors of
Zentalis Pharmaceuticals, LLC on December 21, 2017. 
 Executed on December 21, 2017. 

 

			
	By:	 	 /s/ Anthony Sun

	Name:	 	 Anthony Sun

	Title:	 	 Chief Executive Officer

 ZENTALIS PHARMACEUTICALS, LLC 

PROFITS INTEREST AWARD AGREEMENT 

THIS PROFITS INTEREST AWARD AGREEMENT (this “Agreement”) is made and entered into as of
[            ] (the “Grant Date”), by and between Zentalis Pharmaceuticals, LLC, a Delaware limited liability company (the “Company”), and
[            ] (“Participant”). Capitalized terms used in this Agreement but not otherwise defined herein shall have their respective meanings set forth in the Plan
and the LLC Agreement (each as defined below), as applicable. 
 THE PARTIES HERETO AGREE AS FOLLOWS: 

1.    Issuance of Award; Threshold Amount. 

1.1    Issuance of Award. In consideration of Participant’s agreement to provide services to or for the
benefit of the Company and its Affiliates, effective as of the Grant Date, the Company hereby (a) issues to Participant an Award of [            ] Class B Common Units (the
“Class B Common Units”) of the Company (the “Award”), and (b) if not already a Member, admits Participant as a Member of the Company, on the terms and conditions set forth herein, in the
Zentalis Pharmaceuticals, LLC 2017 Profits Interest Plan (the “Plan”) and in the Amended and Restated Limited Liability Company Agreement of Zentalis Pharmaceuticals, LLC, dated as of December 21, 2017, as amended and/or
restated from time to time (the “LLC Agreement”). The Company and Participant acknowledge and agree that the Award is hereby issued to Participant for the performance of services to or for the benefit of the Company and its
Affiliates in his or her capacity as a Member or in anticipation of Participant becoming a Member. Upon receipt of the Award, Participant shall, automatically and without further action on his or her part, be deemed to be a party to, signatory of
and bound by the LLC Agreement. Participant further acknowledges and agrees that (w) Participant received a copy of the LLC Agreement on or prior to the Grant Date, (x) the execution by Participant of this Agreement evidences
Participant’s intention to be bound by the terms of the LLC Agreement in addition to the terms of this Agreement, (y) the LLC Agreement may be amended or amended and restated from time to time in accordance with its terms, and (z) the
Class B Common Units are subject to all of the terms and restrictions set forth in the LLC Agreement as may be in effect from time to time. Participant shall execute the LLC Agreement or a joinder or counterpart signature page thereto and
deliver such executed joinder or counterpart signature page to the Company with this Agreement. Participant acknowledges that the Company may from time to time issue or cancel (or otherwise modify) Class B Common Units in accordance with the
terms of the LLC Agreement. 
 1.2    Threshold Amount. The Threshold Amount with respect to each Class B
Common Unit subject to the Award shall be $[            ]. 

2.    Vesting; Termination of Service; Restrictions on Award 

2.1    Vesting. Subject to Section 2.2 below and the LLC Agreement, the Award shall vest
according to the Vesting Schedule attached hereto as Exhibit A. 

 2.2    Termination of Service. In the event of
Participant’s Termination of Service, (a) the Award and all Class B Common Units, to the extent not vested as of the date of such Termination of Service (the “Termination Date”) (after taking into consideration any
accelerated vesting that may occur in connection with such termination, if any), together with the proportionate amount of Participant’s Capital Account balance attributable to such unvested Class B Common Units (if any), shall thereupon
automatically and without further action be cancelled and forfeited, and Participant shall have no further right or interest in or with respect to such unvested Class B Common Units (or such proportionate amount of Participant’s Capital
Account balance), and (b) no portion of the Award and no Class B Common Units which are unvested as of Participant’s Termination of Service shall thereafter become vested. Notwithstanding the foregoing, in the event of a Termination
of Service for Cause, all Class B Common Units (both vested and unvested) as of the Termination Date (and the proportionate amount of Participant’s Capital Account balance attributable to such Class B Common Units), shall thereupon
automatically and without further action be cancelled and forfeited, and Participant shall have no further right or interest in or with respect to such Class B Common Units (or such proportionate amount of Participant’s Capital Account
balance). 
 2.3    Restrictions on Awards. The Award and the Class B Common Units are subject to the terms
of the Plan and the terms of the LLC Agreement, including, without limitation, the Transfer and other restrictions set forth in the LLC Agreement. Any permitted transferee of the Award or Class B Common Units shall take such Award and
Class B Common Units subject to the terms of the Plan, this Agreement and the LLC Agreement. Any such permitted transferee must, upon the request of the Company, execute an instrument in form and substance acceptable to the Company agreeing to
be bound by the Plan, the LLC Agreement and this Agreement, and must agree to such other waivers, limitations and restrictions as the Company may reasonably require. Any Transfer of the Award or Class B Common Units which is not made in
compliance with the Plan, the LLC Agreement and this Agreement shall be null and void ab initio and of no force or effect. 

3.    Representations, Warranties, Covenants and Acknowledgments of Participant. Participant hereby represents,
warrants, covenants, acknowledges and agrees on behalf of Participant and his or her spouse, if applicable, that: 

3.1    Investment; Status of Participant. Participant is holding the Award for Participant’s own account, and
not for the account of any other Person. Participant is holding the Award for investment and not with a view to distribution or resale thereof except in compliance with applicable laws regulating securities. 

3.2    Relation to Company. Participant is presently an Employee, Consultant or Director and in such capacity has
become personally familiar with the business of the Company and its Affiliates. 
 3.3    Access to Information.
Participant has had the opportunity to ask questions of, and to receive answers from, the Company with respect to the terms and conditions of the transactions contemplated hereby and with respect to the business, affairs, financial conditions, and
results of operations of the Company. 

  
 2 

 3.4    Registration. Participant understands that the
Class B Common Units have not been registered under the Securities Act, and the Class B Common Units cannot be transferred by Participant other than in accordance with the terms and conditions set forth in the Plan, this Agreement and the
LLC Agreement and, in any event, unless such Class B Common Units are registered under the Securities Act or an exemption from such registration is available. Neither the Company nor any of its Affiliates has made any agreements, covenants or
undertakings whatsoever to register the Class B Common Units under the Securities Act. Neither the Company nor any of its Affiliates has made any representations, warranties or covenants whatsoever as to whether any exemption from the
Securities Act is available. 
 3.5    Public Trading. None of the Company’s Securities is presently
publicly traded, and neither the Company nor any of its Affiliates has made any representations, covenants or agreements as to whether there will be a public market for any of the Company’s Securities. 

3.6    Tax Advice. Neither the Company nor any of its Affiliates or their representatives has made any warranties
or representations to Participant with respect to the income tax consequences of the issuance of the Class B Common Units or the transactions contemplated by this Agreement (including, without limitation, with respect to the making of an
election under Section 83(b) of the Code), and Participant is in no manner relying on the Company or any of its Affiliates or their representatives for an assessment of such tax consequences. Participant is advised to consult with his or her
own tax advisor with respect to such tax consequences and his or her ownership of the Class B Common Units. 

4.    Capital Account. Participant shall make no Capital Contribution to the Company with respect to the Award and,
as a result, Participant’s Capital Account balance in the Company immediately after his or her receipt of the Class B Common Units shall be equal to zero, unless Participant was a Member in the Company prior to such issuance, in which case
Participant’s Capital Account balance shall not be increased as a result of his or her receipt of the Class B Common Units. 

5.    Section 83(b) Election. Participant covenants that he or she shall make an election under Section 83(b)
of the Code (and any comparable election in the state of Participant’s residence) with respect to the Class B Common Units covered by the Award within thirty (30) calendar days following the Grant Date. In connection with such
election, Participant and Participant’s spouse, if applicable, shall execute and deliver to the Company (or to the person for whom the services were performed) with this executed Agreement, a copy of the Election Pursuant to Section 83(b)
of the Internal Revenue Code substantially in the form attached hereto as Exhibit B. Participant represents that Participant has consulted any tax consultant(s) that Participant deems advisable in connection with the filing
of an election under Section 83(b) of the Code and similar state tax provisions. Participant acknowledges that it is Participant’s sole responsibility and not the responsibility of the Company or any of its Affiliates to timely file an
election under Section 83(b) of the Code (and any comparable state election), even if Participant requests that the Company or its Affiliates or any of their representatives make such filing on Participant’s behalf. Participant should
consult his or her tax advisor to determine if there is a comparable election to file in the state of his or her residence. 

  
 3 

 6.    Taxes. The Company and Participant intend that (a) the
Class B Common Units be treated as “profits interests” within the meaning of the Code, Treasury Regulations promulgated thereunder, and any published guidance by the Internal Revenue Service with respect thereto, including, without
limitation, Internal Revenue Service Revenue Procedure 93-27, 1993-2 C.B. 343, as clarified by Internal Revenue Service Revenue Procedure
2001-43, 2001-2 C.B. 191, (b) the issuance of such interests not be a taxable event to the Company or Participant as provided in such Revenue Procedure, and (c) the
LLC Agreement, the Plan and this Agreement be interpreted consistently with such intent. Notwithstanding the foregoing, the Company or its Affiliates, as applicable, may withhold from Participant’s wages, or require Participant to pay to such
entity, any applicable withholding or employment taxes resulting from the issuance of the Award hereunder, from the vesting or lapse of any restrictions imposed on the Award, or from the ownership or disposition of the Class B Common Units.

 7.    Remedies. Participant shall be liable to the Company for all costs and damages, including incidental and
consequential damages, resulting from a disposition of the Award or the Class B Common Units which is in violation of the provisions of this Agreement. Without limiting the generality of the foregoing, Participant agrees that the Company and
its Affiliates shall be entitled to obtain specific performance of the obligations of Participant under this Agreement and immediate injunctive relief in the event any action or proceeding is brought in equity to enforce the same. Participant shall
not urge as a defense that there is an adequate remedy at law. 
 8.    Governing Law. This Agreement shall be
governed by and construed in accordance with the laws of the State of Delaware without regard to any otherwise governing principles of conflicts of law. 

9.    Certificate Restrictive Legends. Certificates evidencing the Award, to the extent such certificates are
issued, may bear such restrictive legends as the Company and/or the Company’s counsel may deem necessary or advisable under applicable law or pursuant to this Agreement, including, without limitation, the following legends or legends
substantially similar thereto: 
 “The offering and sale of the securities represented hereby have not been registered
under the Securities Act of 1933, as amended (the “Securities Act”). Any transfer of such securities will be invalid unless a Registration Statement under the Securities Act is in effect as to such transfer or in the opinion of counsel for
USAT Holdings, LLC such registration is unnecessary in order for such transfer to comply with the Securities Act.” 

“The securities represented hereby are subject to forfeiture, a right of repurchase, restrictions as to transferability
and other restrictions as set forth in (i) an Profits Interest Award Agreement by and between the holder and Zentalis Pharmaceuticals, LLC, (ii) the Zentalis Pharmaceuticals, LLC 2017 Profits Interest Plan and (iii) the Amended and
Restated Limited Liability Company Agreement of Zentalis Pharmaceuticals, LLC, in each case, as may be amended and/or restated from time to time, and such securities may not be sold or otherwise transferred except pursuant to the provisions of such
documents.” 

  
 4 

 10.    Market Standoff. Participant hereby agrees that if so
requested by the Company or any representative of the underwriters in connection with any registration of the offering of any securities of the Company under the Securities Act, Participant shall not, directly or indirectly, sell, offer to sell,
grant any option for the sale of, or otherwise dispose of or transfer, any Securities or other securities of the Company during the 180-day period following the effective date of a registration statement of
the Company filed under the Securities Act; provided, however, that such restriction shall apply only to the first two registration statements of the Company to become effective under the Securities Act which include securities to be sold on
behalf of the Company to the public in an underwritten public offering under the Securities Act. The Company may place a restrictive legend on any security issued to Participant and/or impose stop-transfer instructions with respect to the securities
subject to the foregoing restrictions until the end of such 180-day period. 

11.    No Right to Continued Service. Nothing in this Agreement shall confer upon Participant any right to continue
in the employment or service of the Company (including for the avoidance of doubt any of its Affiliates), or shall interfere with or restrict in any way the rights of the Company or any of its Affiliates, which rights are hereby expressly reserved,
to discharge Participant at any time for any reason whatsoever, with or without Cause, except to the extent expressly provided otherwise in a written agreement between Participant and the Company or any of Affiliates. 

12.    Counterparts. This Agreement may be executed in any number of counterparts, any of which may be executed and
transmitted (without limitation) by facsimile, electronic mail, portable document format (PDF) or any electronic signature complying with the U.S. federal ESIGN Act of 2000 (e.g., www.docusign.com), and each of which shall be deemed to be an
original, but all of which together shall be deemed to be one and the same instrument. 
 13.    Successors and
Assigns. Subject to the limitations set forth in this Agreement, this Agreement shall be binding upon, and inure to the benefit of, the executors, administrators, heirs, legal representatives, successors and assigns of the parties hereto. 

14.    Entire Agreement; Amendments and Waivers. This Agreement, together with the Plan and the LLC Agreement,
constitutes the entire agreement among the parties pertaining to the subject matter hereof and supersedes all prior agreements, understandings, negotiations and discussions, whether oral or written, of the parties. This Agreement may not be amended
except in an instrument in writing signed by Participant and a duly authorized representative of the Company. No amendment, supplement, modification or waiver of this Agreement shall be binding unless executed in writing by the party to be bound
thereby. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provision hereof (whether or not similar), nor shall such waiver constitute a continuing waiver unless otherwise expressly
provided. 

  
 5 

 15.    Invalidity. If any term, provision, covenant or condition
of this Agreement is held by a court of competent jurisdiction to exceed the limitations permitted by applicable law, then the provisions will be deemed reformed to the maximum limitations permitted by applicable law and the parties hereby expressly
acknowledge their desire that in such event such action be taken. If for any reason one or more of the provisions contained in this Agreement or in any other instrument referred to herein, shall, for any reason, be held to be invalid, illegal or
unenforceable in any respect, then to the maximum extent permitted by law, such invalidity, illegality or unenforceability shall not affect any other provision of this Agreement or any other such instrument. 

16.    Titles. The titles, captions or headings of the sections herein are inserted for convenience of reference
only and are not intended to be a part of or to affect the meaning or interpretation of this Agreement. 
 [Signature pages follow]

  
 6 

 IN WITNESS WHEREOF, the parties hereto have executed and delivered this Agreement as of the
date first written above. 
  

			
	 Zentalis Pharmaceuticals, LLC,
 a
Delaware limited liability company

 
			
		
	By:	 	  

 
			
	Name:	 	
	Title:	 	

 [Signature Page to Zentalis Pharmaceuticals, LLC Profits Interest Award Agreement] 

 Participant hereby accepts and agrees to be bound by all of the terms and conditions of this
Agreement. 
  

			
	PARTICIPANT:
	
	      

	Print Name:	 	  

 Participant’s spouse indicates by the execution of this Agreement his or her consent to be bound by
the terms herein as to his or her interests, whether as community property or otherwise, if any, in the Class B Common Units. 
  

			
	Participant’s Spouse:
	
	      

	Print Name:	 	  

 [Signature Page to Zentalis Pharmaceuticals, LLC Profits Interest Award Agreement] 

 EXHIBIT A 

VESTING SCHEDULE 
 Capitalized terms used
in this Exhibit A shall have the meanings given to them in the Agreement to which this Exhibit A is attached. 
 Vesting Commencement Date:
[            ]. 
 A-1 

 EXHIBIT B 

ELECTION PURSUANT TO SECTION 83(b) OF THE 

INTERNAL REVENUE CODE TO INCLUDE IN GROSS 

INCOME THE EXCESS OVER THE PURCHASE PRICE, 

IF ANY, OF THE VALUE OF PROPERTY TRANSFERRED 

IN CONNECTION WITH SERVICES 

The undersigned hereby elects pursuant to Section 83(b) of the Internal Revenue Code of 1986, as amended, to include in the
undersigned’s gross income for the          taxable year the excess (if any) of the fair market value of the property described below, over the amount the undersigned paid for such property, if
any, and supplies herewith the following information in accordance with the Treasury Regulations promulgated under Section 83(b): 

1.    The undersigned’s name, address and taxpayer identification (social security) number are: 

 

	
	Name:
                                         
                                 
	Address:
                                         
                              
	Social Security #:
                                         
               

 The undersigned’s spouse’s name, address and taxpayer identification (social security) number
are (complete if applicable): 
  

	
	 Name:
                                         
                                 

	 Address:
                                         
                              

	Social Security #:
                                         
               

 2.    The property with respect to which the election is made consists of
             Class B Common Units (the “Award”) of Zentalis Pharmaceuticals, LLC, a Delaware limited liability company (the “Company”),
representing an interest in the future profits, losses and distributions of the Company. 
 3.    The date on which the
above property was transferred to the undersigned was                 , and the taxable year to which this election relates is
            . 
 4.    The above property is subject
to the following restrictions: (a) forfeiture if the undersigned ceases to be an employee or director of or consultant to the Company or an affiliate, and (b) certain other restrictions set forth in the Amended and Restated Limited
Liability Company Agreement of Zentalis Pharmaceuticals, LLC (as amended and/or restated from time to time, the “LLC Agreement”), should the undersigned wish to transfer the Award (in whole or in part). 

  
 B-1 

 5.    The Award with respect to which this election is being made is a
“profits interest” received by the undersigned taxpayer in connection with the provision of services to or for the benefit of the Company. The Award does not relate to a substantially certain and predictable stream of income from Company
assets; the undersigned taxpayer does not intend to dispose of the Award within two years of receipt; and the Award is not an interest in a “publicly traded partnership.” Thus, as described in Revenue Procedure 93-27, 1993-2 C.B. 343, and Revenue Procedure 2001-43, 2001-2 C.B. 191, the fair market value
of the above property at the time of transfer (determined without regard to any restrictions other than those which by their terms will never lapse) is $0. 

6.    The amount paid for the above property by the undersigned was $0. 

7.    The undersigned taxpayer will file this election with the Internal Revenue Service office with which taxpayer files
his or her annual income tax return not later than 30 days after the date of transfer of the property. A copy of this election will be furnished to the Company or to the person for whom the services were performed, and the original will be filed
with the income tax return of the undersigned to which this election relates. The undersigned is the person performing the services in connection with which the property was transferred. 

 

			
		  	                                      
                                         
     
	Date:                         	  	Print Name:
                                         
                      
		
		  	                                      
                                         
     
	Date:                         	  	Print Name of Spouse:
                                         
      

  
 B-2 

 ZENTALIS PHARMACEUTICALS, LLC JOINDER AGREEMENT 

This Joinder Agreement (this “Joinder Agreement”) is entered into with effect as of
                ,          by the undersigned (the “Joining Member”), with respect to the Amended
and Restated Limited Liability Company Agreement (as amended from time to time, the “LLC Agreement”) of Zentalis Pharmaceuticals, LLC, a Delaware limited liability company (the “Company”), made and entered into as
of December 21, 2017, among the Members from time to time party thereto. Capitalized terms used but not defined herein shall have the meaning set forth in the LLC Agreement. 

WHEREAS, (i) on or about the date hereof, the Joining Member has received Class B Common Units; and (ii) it is a condition
precedent to the issuance of such Class B Common Units and the admission of such Joining Member as an Additional Member of the Company that the Joining Member execute a Joinder Agreement to the LLC Agreement. 

NOW, THEREFORE, the Joining Member hereby: (i) acknowledges receipt of a copy of the LLC Agreement; (ii) joins fully in the LLC
Agreement as a “Additional Member,” and shall be bound by, and have the benefits as a “Member” of, all the terms and conditions of the LLC Agreement as if such Joining Member was a signatory thereto as a “Member”; and
(iii) agrees that the Class B Common Units issued to such Joining Member are subject to the LLC Agreement. 
 IN WITNESS WHEREOF,
the Joining Member has executed this Joinder Agreement as of the date first written above. 
  

			
	JOINING MEMBER:	  	
		
	                                      
                                         
   	  	
	Print Name:
                                         
                    	  	
		
	Notice Address:	  	
	                                      
                                         
   	  	
	                                      
                                         
   	  	
	                                      
                                         
   	  	
	Tel:
                                         
                                 	  	
	Email:
                                         
                             	  	
		
		  	Accepted:
		
		  	ZENTALIS PHARMACEUTICALS, LLC
		
		  	By:
                                         
                                       
		  	Name:
		  	Title:EX-10.10

 Exhibit 10.10 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is entered into by and between Zeno Management,
Inc., a Delaware corporation (the “Company”) and a wholly owned subsidiary of Zeno Pharma, LLC (the “Parent”), and Anthony Y. Sun, M.D. (“Executive”), and shall be effective as
of February 1, 2019 (the “Effective Date”). 
 WHEREAS, the Company and Executive are parties to that certain
Employment Agreement effective as of February 1, 2018 (the “Prior Agreement”); and 
 WHEREAS, the Company
desires to continue to employ Executive, and Executive desires to continue employment with the Company, and to amend and restate the Prior Agreement, on the terms and conditions set forth in this Agreement. 

NOW, THEREFORE, in consideration of the mutual promises herein contained, the parties agree as follows: 

1.    Definitions. As used in this Agreement, the following terms shall have the following meanings: 

(a)    “Board” means the Board of Directors of the Company. 

(b)    “Cause” means any of the following: 

(i)    Executive’s unauthorized use or disclosure of confidential information or trade secrets of the Company or its
affiliates or any material breach of a written agreement between Executive and the Company or any affiliate, including without limitation a material breach of any employment, confidentiality, non-compete, non-solicit or similar agreement; 
 (ii)    Executive’s commission of,
indictment for or the entry of a plea of guilty or nolo contendere by Executive to, a felony under the laws of the United States or any state thereof or any crime involving dishonesty or moral turpitude (or any similar crime in any
jurisdiction outside the United States); 
 (iii)    Executive’s gross negligence or willful misconduct or
Executive’s willful or repeated failure or refusal to substantially perform assigned duties; 
 (iv)    any act of
fraud, embezzlement, material misappropriation or dishonesty committed by Executive against the Company or its affiliates; or 

(v)    any acts, omissions or statements by Executive which the Company reasonably determines to be materially
detrimental or damaging to the reputation, operations, prospects or business relations of the Company or its affiliates; 

 provided, however, that prior to the determination that “Cause” under clauses (i),
(iii), (iv) or (v) of this Section 1(b) has occurred, the Company shall (A) provide to Executive in writing, in reasonable detail, the reasons for the determination that such “Cause” exists, (B) other than with respect
to clause (v) above which specifies the applicable period of time for Executive to remedy his breach, afford Executive a reasonable opportunity to remedy any such breach, (C) provide Executive an opportunity to be heard prior to the final
decision to terminate Executive’s employment hereunder for such “Cause” and (D) make any decision that such “Cause” exists in good faith. 

The foregoing definition shall not in any way preclude or restrict the right of the Company or any successor or affiliate thereof to discharge
or dismiss Executive for any other acts or omissions, but such other acts or omissions shall not be deemed, for purposes of this Agreement, to constitute grounds for termination for Cause. 

(c)    “Change in Control” shall have the meaning ascribed to such term in the Zeno Pharma, LLC
2017 Profits Interest Plan. 
 (d)    “Code” means the Internal Revenue Code of 1986, as amended
from time to time, and the Treasury Regulations and other interpretive guidance issued thereunder. 

(e)    “Good Reason” means the occurrence of any of the following events or conditions without
Executive’s written consent: 
 (i)    a change in Executive’s position or responsibilities that represents a
substantial reduction in his position or responsibilities as in effect immediately prior thereto; the assignment to Executive of any duties or responsibilities that are materially inconsistent with such position or responsibilities; or any removal
of Executive from or failure to reappoint or reelect Executive to any of such positions, including Executive’s position as a member of the Board or the board of directors of Parent, except in connection with the termination of Executive’s
services for Cause, as a result of his Permanent Disability or death, or by Executive other than for Good Reason; provided, however, that neither a change in Executive’s reporting relationship as a result of a Change in Control
nor the fact that Executive’s reporting relationship is altered following a Change in Control because the Company or its successor is a wholly-owned subsidiary of another entity following such Change in Control shall alone constitute Good
Reason; 
 (ii)    a material reduction in Executive’s annual base salary; 

(iii)    the Company requiring Executive (without Executive’s consent) to be based at any place outside a ten
(10)-mile radius of his then-current place of employment with the Company prior to any such relocation, except for reasonably required travel on the Company’s business; or 

(iv)    any material breach by the Company or any affiliate of its obligations to Executive under any applicable
employment or services agreement between Executive and the Company or such affiliate. 

  
 2 

 Executive must provide written notice to the Company of the occurrence of any of the
foregoing events or conditions without Executive’s written consent within sixty (60) days of the occurrence of such event. The Company or any successor or affiliate shall have a period of thirty (30) days to cure such event or
condition after receipt of written notice of such event from Executive. Executive’s Separation from Service by reason of resignation from employment with the Company for Good Reason must occurs within thirty (30) days following the
expiration of the foregoing thirty (30) day cure period. 
 (f)    “Involuntary
Termination” means (i) Executive’s Separation from Service by reason of Executive’s discharge by the Company other than for Cause, or (ii) Executive’s Separation from Service by reason of Executive’s
resignation of employment with the Company for Good Reason. Executive’s Separation from Service by reason of Executive’s death or discharge by the Company following Executive’s Permanent Disability shall not constitute an Involuntary
Termination. 
 (g)    Executive’s “Permanent Disability” shall be deemed to have occurred
if Executive shall become physically or mentally incapacitated or disabled or otherwise unable fully to discharge his duties hereunder for a period of ninety (90) consecutive calendar days or for one hundred twenty (120) calendar days in
any one hundred eighty (180) calendar-day period. The existence of Executive’s Permanent Disability shall be determined by the Company on the advice of a physician chosen by the Company and the
Company reserves the right to have Executive examined by a physician chosen by the Company at the Company’s expense. 
 (h)
“Separation from Service,” with respect to Executive, means Executive’s “separation from service,” as defined in Treasury Regulation Section 1.409A-1(h). 

2.     Services to Be Rendered. 

(a)    Duties and Responsibilities. Executive shall serve as Chief Executive Officer of the Company. In the
performance of such duties, Executive shall report directly to the Board and shall be subject to the direction of the Board and to such limits upon Executive’s authority as the Board may from time to time impose. Executive hereby
consents to serve as an officer and/or director of the Company, Parent or any subsidiary or affiliate thereof without any additional salary or compensation, if so requested by the Board. Executive shall be employed by the Company on a full time
basis. Executive’s primary place of work shall be the Company’s offices in New York, New York. Executive will also be expected to travel to the Company’s locations as needed in connection with his duties. Executive shall be subject to
and comply with the policies and procedures generally applicable to senior executives of the Company to the extent the same are not inconsistent with any term of this Agreement. 

(b)    Exclusive Services. Executive shall at all times faithfully, industriously and to the best of his ability,
experience and talent perform all of the duties that may be assigned to Executive hereunder and shall devote substantially all of his productive time and efforts to the performance of such duties. Subject to the terms of the Proprietary Information
and Inventions Agreement referred to in Section 5(b), this shall not preclude Executive from (i) serving on industry, trade, civic, or charitable boards or committees; (ii) delivering lectures or fulfilling speaking engagements;
(iii) serving on the board of directors or other similar governance body of 

  
 3 

 
any entity; (iv) managing personal, family and other investments or (v) serving in an advisory capacity for any entity; provided that such activities under this clause
(v) do not interfere with his duties to the Company, as determined in good faith by the Board. 

3.    Compensation and Benefits. The Company shall pay or provide, as the case may be, to Executive the
compensation and other benefits and rights set forth in this Section 3. 
 (a)    Base Salary. The Company
shall pay to Executive a base salary of $437,090.98 per year, payable in accordance with the Company’s usual pay practices (and in any event no less frequently than monthly). Upon the closing of Parent’s Series C financing,
Executive’s base salary shall be automatically increased to $455,090, with retroactive effect to January 1, 2019 (and Executive shall receive a lump sum cash payment in the amount of any incremental base salary that would otherwise have
been paid during the period commencing on January 1, 2019 through the date of the closing of Parent’s Series C financing, as if such increased rate had been in effect, within ten (10) days following such closing). Executive’s
base salary shall be subject to review annually by and at the sole discretion of the Board or its designee. 

(b)    Annual Bonus. Executive shall participate in any annual bonus plan that the Board or its designee may
approve for the senior executives of the Company.    In addition to Executive’s base salary, Executive may be eligible to earn, for each fiscal year of the Company ending during the term of Executive’s employment with
the Company, an annual cash performance bonus under the Company’s bonus plan, as approved from time to time by the Board. Executive’s target bonus under any such annual bonus plan shall be forty-five percent (45%) of Executive’s base
salary actually paid for the year to which such annual bonus relates (the “Target Bonus”). Executive’s actual annual bonus will be determined on the basis of Executive’s and/or the Company’s or its
affiliates’ attainment of financial or other performance criteria established by the Board or its designee in accordance with the terms and conditions of such bonus plan. Except as otherwise provided in this Agreement, Executive must be
employed by the Company on the date of payment of such annual bonus in order to be eligible to receive such annual bonus. Executive hereby acknowledges and agrees that nothing contained herein confers upon Executive any right to an annual bonus in
any year, and that whether the Company pays Executive an annual bonus and the amount of any such annual bonus will be determined by the Company in its sole discretion. 

(c)    Benefits. Executive shall be entitled to participate in benefits under the Company’s benefit plans and
arrangements, including, without limitation, any employee benefit plan or arrangement made available in the future by the Company to its senior executives, subject to and on a basis consistent with the terms, conditions and overall administration of
such plans and arrangements. The Company shall have the right to amend or delete any such benefit plan or arrangement made available by the Company to its senior executives and not otherwise specifically provided for herein. 

(d)    Expenses. The Company shall reimburse Executive for reasonable out-of-pocket business expenses incurred in connection with the performance of his duties hereunder, subject to such policies as the Company may from time to time establish, and Executive furnishing the
Company with evidence in the form of receipts satisfactory to the Company substantiating the claimed expenditures. 

  
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 (e)     Paid Time Off. Executive shall be entitled to such
periods of paid time off (“PTO”) each year as provided from time to time under the Company’s PTO policy and as otherwise provided for senior executive officers; provided, however, that Executive shall be
entitled to a minimum of twenty (20) days of PTO per year. 
 (f)    Equity and Other Benefit Plans.
Executive shall be entitled to participate in any equity or other employee benefit plan that is generally available to senior executive officers of the Company. Except as otherwise provided in this Agreement, Executive’s participation in and
benefits under any such plan shall be on the terms and subject to the conditions specified in the governing document of the particular plan. 

4.    Severance. Executive shall be entitled to receive benefits upon a Separation from Service only as set forth
in this Section 4: 
 (a)    At-Will Employment; Termination. The
Company and Executive acknowledge that Executive’s employment is and shall continue to be at-will, as defined under applicable law, and that Executive’s employment with the Company may be terminated
by either party at any time for any or no reason, with or without notice. If Executive’s employment terminates for any reason, Executive shall not be entitled to any payments, benefits, damages, awards or compensation other than as provided in
this Agreement. Executive’s employment under this Agreement shall be terminated immediately on the death of Executive. 

(b)    Severance Upon Involuntary Termination. Subject to Sections 4(d) and 9(o) and Executive’s continued
compliance with Section 5, if Executive’s employment is Involuntarily Terminated, Executive shall be entitled to receive, in lieu of any severance benefits to which Executive may otherwise be entitled under any severance plan or program of
the Company, the benefits provided below: 
 (i)    the Company shall pay to Executive his fully earned but unpaid base
salary, when due, through the date of Executive’s Involuntary Termination at the rate then in effect, accrued and unused PTO, plus all other benefits, if any, under any Company group retirement plan, nonqualified deferred compensation plan,
equity award plan or agreement, health benefits plan or other Company group benefit plan to which Executive may be entitled pursuant to the terms of such plans or agreements at the time of Executive’s Involuntary Termination (the
“Accrued Obligations”); 
 (ii)    Executive shall be entitled to receive severance pay in an
amount equal to (A) Executive’s monthly base salary as in effect immediately prior to the date of Executive’s Involuntary Termination, multiplied by (B) the Severance Multiplier (as defined below), which amount shall be payable
in a lump sum sixty (60) days following Executive’s Involuntary Termination. For purposes of this Section 4, “Severance Multiplier” shall mean the sum of (1) nine (9) plus (2) one (1) month for each
additional twelve-month period of Executive’s employment with the Company or its affiliates (including Zeno Pharmaceuticals, Inc.) following September 1, 2015; provided, however, that the Severance Multiplier shall not exceed
twelve (12); 
 (iii)    Executive shall be entitled to receive Executive’s Target Bonus for the year in which
Executive’s Involuntary Termination occurs, prorated for the portion of the year that has expired prior to the date of Executive’s Involuntary Termination, which amount shall be payable in a lump sum sixty (60) days following
Executive’s Involuntary Termination; 

  
 5 

 (iv)    for the period beginning on the date of Executive’s
Involuntary Termination and ending on the date which is such number of full months following the date of Executive’s Involuntary Termination as is equal to the Severance Multiplier (or, if earlier, (A) the date on which the applicable
continuation period under the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”) expires or (B) the date Executive becomes eligible to receive the equivalent or increased healthcare coverage by
means of subsequent employment or self-employment) (such period, the “COBRA Coverage Period”), if Executive and/or his eligible dependents who were covered under the Company’s health insurance plans as of the date of
Executive’s Involuntary Termination elect to have COBRA coverage and are eligible for such coverage, the Company shall pay for or reimburse Executive on a monthly basis for an amount equal to (1) the monthly premium Executive and/or his
covered dependents, as applicable, are required to pay for continuation coverage pursuant to COBRA for Executive and/or his eligible dependents, as applicable, who were covered under the Company’s health plans as of the date of Executive’s
Involuntary Termination (calculated by reference to the premium as of the date of Executive’s Involuntary Termination) less (2) the amount Executive would have had to pay to receive group health coverage for Executive and/or his covered
dependents, as applicable, based on the cost sharing levels in effect on the date of Executive’s Involuntary Termination. If any of the Company’s health benefits are self-funded as of the date of Executive’s Involuntary Termination,
or if the Company cannot provide the foregoing benefits in a manner that is exempt from Section 409A (as defined below) or that is otherwise compliant with applicable law (including, without limitation, Section 2716 of the Public Health
Service Act), instead of providing the payments or reimbursements as set forth above, the Company shall instead pay to Executive the foregoing monthly amount as a taxable monthly payment for the COBRA Coverage Period (or any remaining portion
thereof). Executive shall be solely responsible for all matters relating to continuation of coverage pursuant to COBRA, including, without limitation, the election of such coverage and the timely payment of premiums. Executive shall notify the
Company immediately if Executive becomes eligible to receive the equivalent or increased healthcare coverage by means of subsequent employment or self-employment. 

(v)    Notwithstanding anything to the contrary in this Section 4(b), and subject to Sections 4(d) and 9(o) and
Executive’s continued compliance with Section 5, in the event of Executive’s Involuntary Termination within twelve (12) months following a Change in Control, (A) the Severance Multiplier for purposes of clauses (ii) and
(iv) above shall be deemed to be twelve (12), and (B) the Target Bonus for purposes of clause (iii) above shall not be subject to proration. 

(c)    Termination for Cause, Voluntary Resignation Without Good Reason, Death or Termination for Permanent
Disability. In the event of Executive’s termination of employment as a result of Executive’s discharge by the Company for Cause, Executive’s resignation without Good Reason, Executive’s death or Executive’s termination
of employment following Executive’s Permanent Disability, the Company shall not have any other or further obligations to Executive under this Agreement (including any financial obligations) except that Executive shall be entitled to receive the
Accrued Obligations. The foregoing shall be in addition to, and not in lieu of, any and all other rights and remedies which may be available to the Company under the circumstances, whether at law or in equity. 

  
 6 

 (d)    Release. As a condition to Executive’s receipt of any
post-termination benefits pursuant to Section 4(b) above, Executive (or, in the event of Executive’s incapacity as a result of his Permanent Disability, Executive’s legal representative) shall execute and not revoke a general release
of all claims in favor of the Company and its affiliates (the “Release”) in the form attached hereto as Exhibit A. In the event the Release does not become effective within the fifty-five (55) day period following the
date of Executive’s Involuntary Termination, Executive shall not be entitled to the aforesaid payments and benefits. 

(e)    Exclusive Remedy. Except as otherwise expressly required by law (e.g., COBRA) or as specifically provided
herein, all of Executive’s rights to salary, severance, benefits, bonuses and other amounts hereunder (if any) accruing after the termination of Executive’s employment shall cease upon such termination. In the event of Executive’s
termination of employment with the Company, Executive’s sole remedy shall be to receive the payments and benefits described in this Section 4. In addition, Executive acknowledges and agrees that he is not entitled to any reimbursement by
the Company for any taxes payable by Executive as a result of the payments and benefits received by Executive pursuant to this Section 4, including, without limitation, any excise tax imposed by Section 4999 of the Code. Any payments made
to Executive under this Section 4 shall be inclusive of any amounts or benefits to which Executive may be entitled pursuant to the Worker Adjustment and Retraining Notification Act, 29 U.S.C. Sections 2101 et seq., and the Department of Labor
regulations thereunder, or any similar state statute. 
 (f)    No Mitigation. Except as otherwise provided in
Section 4(b)(iv) above, Executive shall not be required to mitigate the amount of any payment provided for in this Section 4 by seeking other employment or otherwise, nor shall the amount of any payment or benefit provided for in this
Section 4 be reduced by any compensation earned by Executive as the result of employment by another employer or self-employment or by retirement benefits; provided, however, that loans, advances or other amounts owed by Executive
to the Company may be offset by the Company against amounts payable to Executive under this Section 4. 

(g)    Return of the Company’s Property. In the event of Executive’s termination of employment for any
reason, the Company shall have the right, at its option, to require Executive to vacate his offices prior to or on the effective date of separation and to cease all activities on the Company’s behalf. Upon Executive’s termination of
employment in any manner, as a condition to Executive’s receipt of any severance benefits described in this Agreement, Executive shall immediately surrender to the Company all lists, books and records of, or in connection with, the
Company’s business, and all other property belonging to the Company, it being distinctly understood that all such lists, books and records, and other documents, are the property of the Company. Executive shall deliver to the Company a signed
statement certifying compliance with this Section 4(g) prior to the receipt of any severance benefits described in this Agreement. 

  
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 5.    Certain Covenants. 

(a)    Noncompetition. Except as may otherwise be approved by the Board, during the term of Executive’s
employment, Executive shall not have any ownership interest (of record or beneficial) in, or have any interest as an employee, salesman, consultant, officer or director in, or otherwise aid or assist in any manner, any firm, corporation,
partnership, proprietorship or other business that engages in any county, city or part thereof in the United States and/or any foreign country in a business which competes directly or indirectly (as determined by the Board) with the Company’s
business in such county, city or part thereof, so long as the Company, or any successor in interest of the Company to the business and goodwill of the Company, remains engaged in such business in such county, city or part thereof or continues to
solicit customers or potential customers therein; provided, however, that Executive may own, directly or indirectly, solely as an investment, securities of any entity which are traded on any national securities exchange if Executive
(i) is not a controlling person of, or a member of a group which controls, such entity; or (ii) does not, directly or indirectly, own one percent (1%) or more of any class of securities of any such entity. 

(b)    Confidential Information. Executive and the Company have entered into the Company’s standard
proprietary information and inventions assignment agreement (the “Proprietary Information and Inventions Agreement”). Executive agrees to perform each and every obligation of Executive therein contained. 

(c)    Solicitation of Employees. During the term of Executive’s employment or service and for one
(1) year thereafter (the “Restricted Period”), Executive will not, either directly or through others, solicit or attempt to solicit any employee, independent contractor or consultant of the Company or its affiliates to
terminate his relationship with the Company or its affiliates in order to become an employee, consultant or independent contractor to or for any other person or entity, or otherwise encourage or solicit any employee of the Company or its affiliates
to leave the Company or such affiliates for any reason or to devote less than all of any such employee’s efforts to the affairs of the Company; provided that the foregoing shall not affect any responsibility Executive may have as an employee of
the Company with respect to the bona fide hiring and firing of Company personnel. 
 (d)    Solicitation of
Consultants. Executive shall not during the term of Executive’s employment or service and for the Restricted Period, directly or indirectly, hire, solicit or encourage to cease work with the Company or any of its affiliates any consultant
then under contract with the Company or any of its affiliates. 
 (e)    Nondisparagement. Executive agrees that
neither he nor anyone acting by, through, under or in concert with him shall disparage or otherwise communicate negative statements or opinions about the Company, Parent, or their respective board members, officers, employees or businesses. The
Company agrees that neither its Board members nor officers, nor the board members or officers of Parent, shall disparage or otherwise communicate negative statements or opinions about Executive. Except as may be required by law, neither Executive,
nor any member of Executive’s family, nor anyone else acting by, through, under or in concert with Executive will disclose to any individual or entity (other than Executive’s legal or tax advisors) the terms of this Agreement. 

(f)    Rights and Remedies Upon Breach. If Executive breaches or threatens to commit a breach of any of the
provisions of this Section 5 (the “Restrictive Covenants”), the Company shall have the following rights and remedies, each of which rights and remedies shall be 

  
 8 

 
independent of the other and severally enforceable, and all of which rights and remedies shall be in addition to, and not in lieu of, any other rights and remedies available to the Company under
law or in equity: 
 (i)    Specific Performance. The right and remedy to have the Restrictive Covenants
specifically enforced by any court having equity jurisdiction, all without the need to post a bond or any other security or to prove any amount of actual damage or that money damages would not provide an adequate remedy, it being acknowledged and
agreed that any such breach or threatened breach will cause irreparable injury to the Company and that money damages will not provide adequate remedy to the Company; and 

(ii)    Accounting and Indemnification. The right and remedy to require Executive (A) to account for and pay
over to the Company all compensation, profits, monies, accruals, increments or other benefits derived or received by Executive or any associated party deriving such benefits as a result of any such breach of the Restrictive Covenants; and
(B) to indemnify the Company against any other losses, damages (including special and consequential damages), costs and expenses, including actual attorneys’ fees and court costs, which may be incurred by them and which result from or
arise out of any such breach or threatened breach of the Restrictive Covenants. 
 (g)    Severability of
Covenants/Blue Pencilling. If any court determines that any of the Restrictive Covenants, or any part thereof, is invalid or unenforceable, the remainder of the Restrictive Covenants shall not thereby be affected and shall be given full effect,
without regard to the invalid portions. If any court determines that any of the Restrictive Covenants, or any part thereof, are unenforceable because of the duration of such provision or the area covered thereby, such court shall have the power to
reduce the duration or area of such provision and, in its reduced form, such provision shall then be enforceable and shall be enforced. Executive hereby waives any and all right to attack the validity of the Restrictive Covenants on the grounds of
the breadth of their geographic scope or the length of their term. 
 (h)    Enforceability in Jurisdictions. The
Company and Executive intend to and do hereby confer jurisdiction to enforce the Restrictive Covenants upon the courts of any jurisdiction within the geographical scope of such covenants. If the courts of any one or more of such jurisdictions hold
the Restrictive Covenants wholly unenforceable by reason of the breadth of such scope or otherwise, it is the intention of the Company and Executive that such determination not bar or in any way affect the right of the Company to the relief provided
above in the courts of any other jurisdiction within the geographical scope of such covenants, as to breaches of such covenants in such other respective jurisdictions, such covenants as they relate to each jurisdiction being, for this purpose,
severable into diverse and independent covenants. 
 (i)    Whistleblower Provision. Nothing herein shall be
construed to prohibit Executive from communicating directly with, cooperating with, or providing information to, any government regulator, including, but not limited to, the U.S. Securities and Exchange Commission, the U.S. Commodity Futures Trading
Commission, or the U.S. Department of Justice. Executive acknowledges that the Company has provided Executive with the following notice of immunity rights in compliance with the requirements of the Defend Trade Secrets Act: (i) Executive shall
not be held criminally or civilly liable under any Federal or State trade secret 

  
 9 

 
law for the disclosure of proprietary information that is made in confidence to a Federal, State, or local government official or to an attorney solely for the purpose of reporting or
investigating a suspected violation of law, (ii) Executive shall not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of proprietary information that is made in a complaint or other document
filed in a lawsuit or other proceeding, if such filing is made under seal and (iii) if Executive files a lawsuit for retaliation by the Company for reporting a suspected violation of law, Executive may disclose the proprietary information to
Executive’s attorney and use the proprietary information in the court proceeding, if Executive files any document containing the proprietary information under seal, and does not disclose the proprietary information, except pursuant to court
order. 
 (j)    Definitions. For purposes of this Section 5, the term “Company”
means not only Zeno Management, Inc., but also Parent as well as any company, partnership or entity which, directly or indirectly, controls, is controlled by or is under common control with Zeno Management, Inc. 

6.    Insurance; Indemnification. 

(a)    Insurance. The Company shall have the right to take out life, health, accident, “key-man” or other insurance covering Executive, in the name of the Company and at the Company’s expense in any amount deemed appropriate by the Company. Executive shall assist the Company in
obtaining such insurance, including, without limitation, submitting to any required examinations and providing information and data required by insurance companies. 

(b)    Indemnification. Executive will be provided with indemnification against third party claims related to his
work for the Company to the extent permitted by Delaware law. The Company shall provide Executive with directors and officers liability insurance coverage at least as favorable as that which the Company may maintain from time to time for members of
the Board and other executive officers. 
 7.    Arbitration. Any dispute, claim or controversy based on, arising
out of or relating to Executive’s employment or this Agreement shall be settled by final and binding arbitration in New York, New York, before a single neutral arbitrator in accordance with the JAMS Employment Arbitration Rules and Procedures
(the “Rules”), and judgment on the award rendered by the arbitrator may be entered in any court having jurisdiction. The Rules may be found online at www.jamsadr.com. If the parties are unable to agree upon an arbitrator, one
shall be appointed by JAMS in accordance with its Rules. Each party shall pay the fees of its own attorneys, the expenses of its witnesses and all other expenses connected with presenting its case; provided, however, Executive and the
Company agree that, to the extent permitted by law, the arbitrator may, in his or her discretion, award reasonable attorneys’ fees to the prevailing party; provided, further, that the prevailing party shall be reimbursed for such
fees, costs and expenses within forty-five (45) days following any such award, but in no event later than the last day of Executive’s taxable year following the taxable year in which the fees, costs and expenses were incurred;
provided, further, that the parties’ obligations pursuant to this sentence shall terminate on the tenth (10th) anniversary of the date of Executive’s termination of
employment. Other costs of the arbitration, including the cost of any record or transcripts of the arbitration, JAMS administrative fees, the fee of the arbitrator, and all other fees and costs, shall be borne by the Company. This Section 7 is
intended 

  
 10 

 
to be the exclusive method for resolving any and all claims by the parties against each other for payment of damages under this Agreement or relating to Executive’s employment;
provided, however, that Executive shall retain the right to file administrative charges with or seek relief through any government agency of competent jurisdiction, and to participate in any government investigation, including but not
limited to (a) claims for workers’ compensation, state disability insurance or unemployment insurance; (b) administrative claims brought before any state or federal governmental authority; provided, however, that any
appeal from an award or from denial of an award of wages and/or waiting time penalties shall be arbitrated pursuant to the terms of this Agreement; and (c) claims for administrative relief from the United States Equal Employment Opportunity
Commission and/or any similar state agency in any applicable jurisdiction); provided, further, that Executive shall not be entitled to obtain any monetary relief through such agencies other than workers’ compensation benefits or
unemployment insurance benefits. This Agreement shall not limit either party’s right to obtain any provisional remedy, including, without limitation, injunctive or similar relief, from any court of competent jurisdiction as may be necessary to
protect their rights and interests pending the outcome of arbitration, including without limitation injunctive relief, in any court of competent jurisdiction. Seeking any such relief shall not be deemed to be a waiver of such party’s right to
compel arbitration. Both Executive and the Company expressly waive their right to a jury trial. 
 8.    General
Relationship. Executive shall be considered an employee of the Company within the meaning of all federal, state and local laws and regulations including, but not limited to, laws and regulations governing unemployment insurance, workers’
compensation, industrial accident, labor and taxes. 
 9.    Miscellaneous. 

(a)    Modification; Prior Claims. This Agreement and the Proprietary Information and Inventions Agreement (and the
other documents referenced therein) set forth the entire understanding of the parties with respect to the subject matter hereof, and supersede all existing agreements between them concerning such subject matter, including the Prior Agreement. This
Agreement may be amended or modified only with the written consent of Executive and an authorized representative of the Company. No oral waiver, amendment or modification will be effective under any circumstances whatsoever. 

(b)    Assignment; Assumption by Successor. The rights of the Company under this Agreement may, without the consent
of Executive, be assigned by the Company, in its sole and unfettered discretion, to any person, firm, corporation or other business entity which at any time, whether by purchase, merger or otherwise, directly or indirectly, acquires all or
substantially all of the assets or business of the Company. The Company will require any successor (whether direct or indirect, by purchase, merger or otherwise) to all or substantially all of the business or assets of the Company expressly to
assume and to agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform it if no such succession had taken place; provided, however, that no such assumption shall relieve
the Company of its obligations hereunder. As used in this Agreement, the “Company” shall mean the Company as hereinbefore defined and any successor to its business and/or assets as aforesaid which assumes and agrees to
perform this Agreement by operation of law or otherwise. 

  
 11 

 (c)    Survival. The covenants, agreements, representations and
warranties contained in or made in Sections 4, 5, 6, 7 and 9 of this Agreement shall survive Executive’s termination of employment. 

(d)    Third-Party Beneficiaries. Except as expressly set forth
herein, this Agreement does not create, and shall not be construed as creating, any rights enforceable by any person not a party to this Agreement. 

(e)    Waiver. The failure of either party hereto at any time to enforce performance by the other party of any
provision of this Agreement shall in no way affect such party’s rights thereafter to enforce the same, nor shall the waiver by either party of any breach of any provision hereof be deemed to be a waiver by such party of any other breach of the
same or any other provision hereof. 
 (f)    Section Headings. The headings of the several sections in this
Agreement are inserted solely for the convenience of the parties and are not a part of and are not intended to govern, limit or aid in the construction of any term or provision hereof. 

(g)    Notices. Any notice required or permitted by this Agreement shall be in writing and shall be delivered as
follows with notice deemed given as indicated: (i) by personal delivery when delivered personally; (ii) by overnight courier upon written verification of receipt; (iii) by email, telecopy or facsimile transmission upon acknowledgment
of receipt of electronic transmission; or (iv) by certified or registered mail, return receipt requested, upon verification of receipt. Notice shall be sent to Executive at the address listed on the Company’s personnel records and to the
Company at its principal place of business, or such other address as either party may specify in writing. 

(h)    Severability. All Sections, clauses and covenants contained in this Agreement are severable, and in the
event any of them shall be held to be invalid by any court, this Agreement shall be interpreted as if such invalid Sections, clauses or covenants were not contained herein. 

(i)    Governing Law and Venue. This Agreement is to be governed by and construed in accordance with the laws of
the State of New York applicable to contracts made and to be performed wholly within such State, and without regard to the conflicts of laws principles thereof. Except as provided in Sections 5 and 7, any suit brought hereon shall be brought in
the state or federal courts sitting in New York, New York, the parties hereto hereby waiving any claim or defense that such forum is not convenient or proper. Each party hereby agrees that any such court shall have in personam jurisdiction over it
and consents to service of process in any manner authorized by New York law. 

(j)    Non-transferability of Interest. None of the rights of Executive to
receive any form of compensation payable pursuant to this Agreement shall be assignable or transferable except through a testamentary disposition or by the laws of descent and distribution upon the death of Executive. Any attempted assignment,
transfer, conveyance, or other disposition (other than as aforesaid) of any interest in the rights of Executive to receive any form of compensation to be made by the Company pursuant to this Agreement shall be void. 

  
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 (k)    Gender. Where the context so requires, the use of the
masculine gender shall include the feminine and/or neuter genders and the singular shall include the plural, and vice versa, and the word “person” shall include any corporation, firm, partnership or other form of association. 

(l)    Counterparts; Facsimile or .pdf Signatures. This Agreement may be executed in any number of counterparts,
each of which when so executed and delivered will be deemed an original, and all of which together shall constitute one and the same agreement. This Agreement may be executed and delivered by facsimile or by .pdf file and upon such delivery the
facsimile or .pdf signature will be deemed to have the same effect as if the original signature had been delivered to the other party. 

(m)    Construction. The language in all parts of this Agreement shall in all cases be construed simply, according
to its fair meaning, and not strictly for or against any of the parties hereto. Without limitation, there shall be no presumption against any party on the ground that such party was responsible for drafting this Agreement or any part thereof. 

(n)    Withholding and Other Deductions. All compensation payable to Executive hereunder shall be subject to such
deductions as the Company is from time to time required to make pursuant to law, governmental regulation or order. 

(o)    Code Section 409A. 

(i)    This Agreement is not intended to provide for any deferral of compensation subject to Section 409A of the
Code, and, accordingly, the severance payments payable under Section 4(b)(ii) and (iii) shall be paid no later than the later of: (A) the fifteenth (15th) day of the third month following Executive’s first taxable year in which
such amounts are no longer subject to a substantial risk of forfeiture, and (B) the fifteenth (15th) day of the third month following first taxable year of the Company in which such amounts are is no longer subject to substantial risk of
forfeiture, as determined in accordance with Code Section 409A and any Treasury Regulations and other guidance issued thereunder. To the extent applicable, this Agreement shall be interpreted in accordance with Code Section 409A and
Department of Treasury regulations and other interpretive guidance issued thereunder. Each series of installment payments made under this Agreement is hereby designated as a series of “separate payments” within the meaning of
Section 409A of the Code. For purposes of this Agreement, all references to Executive’s “termination of employment” shall mean Executive’s Separation from Service. 

(ii)    If Executive is a “specified employee” (as defined in Section 409A of the Code), as determined by
the Company in accordance with Section 409A of the Code, on the date of Executive’s Separation from Service, to the extent that the payments or benefits under this Agreement are subject to Section 409A of the Code and the delayed
payment or distribution of all or any portion of such amounts to which Executive is entitled under this Agreement is required in order to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code, then such portion deferred
pursuant to this Section 9(o)(ii) shall be paid or distributed to Executive in a lump sum on the earlier of (A) the date that is six (6)-months following Executive’s Separation from Service, (B) the date of Executive’s death
or (C) the earliest date as is permitted under Section 409A of the Code. Any remaining payments due under the Agreement shall be paid as otherwise provided herein. 

  
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 (iii)    To the extent applicable, this Agreement shall be
interpreted in accordance with the applicable exemptions from Section 409A of the Code. If Executive and the Company determine that any payments or benefits payable under this Agreement intended to comply with Sections 409A(a)(2), (3) and
(4) of the Code do not comply with Section 409A of the Code, Executive and the Company agree to amend this Agreement, or take such other actions as Executive and the Company deem reasonably necessary or appropriate, to comply with the
requirements of Section 409A of the Code and the Treasury Regulations thereunder (and any applicable transition relief) while preserving the economic agreement of the parties. To the extent that any provision in this Agreement is ambiguous as
to its compliance with Section 409A of the Code, the provision shall be read in such a manner that no payments payable under this Agreement shall be subject to an “additional tax” as defined in Section 409A(a)(1)(B) of the
Code. 
 (iv)    Any reimbursement of expenses or in-kind benefits payable
under this Agreement shall be made in accordance with Treasury Regulation Section 1.409A-3(i)(1)(iv) and shall be paid on or before the last day of Executive’s taxable year following the taxable year
in which Executive incurred the expenses. The amount of expenses reimbursed or in-kind benefits payable during any taxable year of Executive’s shall not affect the amount eligible for reimbursement or in-kind benefits payable in any other taxable year of Executive’s, and Executive’s right to reimbursement for such amounts shall not be subject to liquidation or exchange for any other benefit. 

[SIGNATURE PAGE FOLLOWS] 

  
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 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first set forth
above. 
  

			
	ZENO MANAGEMENT, INC.
		
	By:	 	 /s/ Kevin Bunker, Ph.D.

	Name:	 	Kevin Bunker, Ph.D.
	Title:	 	Chief Operations Officer
	
	EXECUTIVE
	
	 /s/ Anthony Y. Sun, M.D.

	Anthony Y. Sun, M.D.

 SIGNATURE PAGE TO AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

 EXHIBIT A 

GENERAL RELEASE OF CLAIMS 

[The language in this Release may change based on legal developments and evolving best practices; this form is provided as an example of
what will be included in the final Release document.] 
 This General Release of Claims (“Release”) is entered
into as of this              day of                 ,
            , between Anthony Y. Sun, M.D. (“Executive”), and Zeno Management, Inc. (the “Company”) (collectively referred to herein as the
“Parties”). 
 WHEREAS, Executive and the Company are parties to that certain Amended and Restated Employment
Agreement dated as of February 1, 2019 (the “Agreement”); 
 WHEREAS, the Parties agree that Executive is
entitled to certain severance benefits under the Agreement, subject to Executive’s execution of this Release; and 
 WHEREAS, the
Company and Executive now wish to fully and finally to resolve all matters between them. 
 NOW, THEREFORE, in consideration of, and subject
to, the severance benefits payable to Executive pursuant to the Agreement, the adequacy of which is hereby acknowledged by Executive, and which Executive acknowledges that he would not otherwise be entitled to receive, Executive and the Company
hereby agree as follows: 
 1.    General Release of Claims by Executive. 

(a) Executive, on behalf of himself and his executors, heirs, administrators, representatives and assigns, hereby agrees to release and forever
discharge the Company and all predecessors, successors and their respective parent corporations, affiliates, related, and/or subsidiary entities, and all of their past and present investors, directors, shareholders, officers, general or limited
partners, employees, attorneys, agents and representatives, and the employee benefit plans in which Executive is or has been a participant by virtue of his employment with or service to the Company (collectively, the “Company
Releasees”), from any and all claims, debts, demands, accounts, judgments, rights, causes of action, equitable relief, damages, costs, charges, complaints, obligations, promises, agreements, controversies, suits, expenses, compensation,
responsibility and liability of every kind and character whatsoever (including attorneys’ fees and costs), whether in law or equity, known or unknown, asserted or unasserted, suspected or unsuspected (collectively,
“Claims”), which Executive has or may have had against such entities based on any events or circumstances arising or occurring on or prior to the date hereof or on or prior to the date hereof, arising directly or indirectly
out of, relating to, or in any other way involving in any manner whatsoever Executive’s employment by or service to the Company or the termination thereof, including any and all claims arising under federal, state, or local laws relating to
employment, including without limitation claims of wrongful discharge, breach of express or implied contract, fraud, misrepresentation, defamation, or liability in tort, and claims of any kind 

  
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that may be brought in any court or administrative agency including, without limitation, claims under Title VII of the Civil Rights Act of 1964, as amended, 42 U.S.C. Section 2000, et
seq.; the Americans with Disabilities Act, as amended, 42 U.S.C. § 12101 et seq.; the Rehabilitation Act of 1973, as amended, 29 U.S.C. § 701 et seq.; the Civil Rights Act of 1866, and
the Civil Rights Act of 1991; 42 U.S.C. Section 1981, et seq.; the Age Discrimination in Employment Act, as amended, 29 U.S.C. Section 621, et seq. (the “ADEA”); the Equal Pay Act, as
amended, 29 U.S.C. Section 206(d); regulations of the Office of Federal Contract Compliance, 41 C.F.R. Section 60, et seq.; the Family and Medical Leave Act, as amended, 29 U.S.C. § 2601
et seq.; the Fair Labor Standards Act of 1938, as amended, 29 U.S.C. § 201 et seq.; the Employee Retirement Income Security Act, as amended, 29 U.S.C. § 1001 et seq. 

Notwithstanding the generality of the foregoing, Executive does not release the following claims: 

(i)    Claims for unemployment compensation or any state disability insurance benefits pursuant to the
terms of applicable state law; 
 (ii)    Claims for workers’ compensation insurance benefits under
the terms of any worker’s compensation insurance policy or fund of the Company; 
 (iii)    Claims
pursuant to the terms and conditions of the federal law known as COBRA; 
 (iv)    Claims for indemnity
under the bylaws of the Company, as provided for by Delaware law or under any applicable insurance policy with respect to Executive’s liability as an employee, director or officer of the Company; 

(v)    Executive’s right to bring to the attention of the Equal Employment Opportunity Commission or
any other federal, state or local government agency claims of discrimination, or from participating in an investigation or proceeding conducted by the Equal Employment Opportunity Commission or any other federal, state or local government agency;
provided, however, that Executive does release his right to secure any damages for alleged discriminatory treatment; 

(vi)    Claims based on any right Executive may have to enforce the Company’s executory obligations
under the Agreement; 
 (vii)    Claims Executive may have to vested or earned compensation and benefits;
and 
 (viii)    Executive’s right to communicate or cooperate with any government agency. 

  
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 (b) EXECUTIVE ACKNOWLEDGES THAT HE HAS BEEN ADVISED OF AND IS FAMILIAR WITH THE PROVISIONS
OF CALIFORNIA CIVIL CODE SECTION 1542, WHICH PROVIDES AS FOLLOWS: 
 “A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS THAT THE CREDITOR
OR RELEASING PARTY DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE AND THAT, IF KNOWN BY HIM OR HER, WOULD HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR OR RELEASED PARTY.” 

BEING AWARE OF SAID CODE SECTION, EXECUTIVE HEREBY EXPRESSLY WAIVES ANY RIGHTS HE MAY HAVE THEREUNDER, AS WELL AS UNDER ANY OTHER STATUTES OR COMMON LAW
PRINCIPLES OF SIMILAR EFFECT. 
 [Note: Clauses (c), (d) and (e) apply only if Executive is age 40 or older at time of termination] 

(c)    Executive acknowledges that this Release was presented to him on the date indicated above and that Executive is
entitled to have [twenty-one (21)][forty-five (45)] days’ time in which to consider it. Executive further acknowledges that the Company has advised him that he is waiving his rights under the ADEA, and
that Executive should consult with an attorney of his choice before signing this Release, and Executive has had sufficient time to consider the terms of this Release. Executive represents and acknowledges that if Executive executes this Release
before [twenty-one (21)][forty-five (45)] days have elapsed, Executive does so knowingly, voluntarily, and upon the advice and with the approval of Executive’s legal counsel (if any), and that Executive
voluntarily waives any remaining consideration period. 
 (d)    Executive understands that after executing this
Release, Executive has the right to revoke it within seven (7) days after his execution of it. Executive understands that this Release will not become effective and enforceable unless the seven (7) day revocation period passes and
Executive does not revoke the Release in writing. Executive understands that this Release may not be revoked after the seven (7) day revocation period has passed. Executive also understands that any revocation of this Release must be made in
writing and delivered to the Company at its principal place of business within the seven (7) day period. 

(e)    Executive understands that this Release shall become effective, irrevocable, and binding upon Executive on the
eighth (8th) day after his execution of it, so long as Executive has not revoked it within the time period and in the manner specified in clause (d) above. 

(f)    Executive further understands that Executive will not be given any severance benefits under the Agreement unless
this Release is effective on or before the date that is fifty-five (55) days following the date of Executive’s termination of employment. 

2.    No Assignment. Executive represents and warrants to the Company Releasees that there has been no assignment
or other transfer of any interest in any Claim that Executive may have against the Company Releasees. Executive agrees to indemnify and hold harmless the Company Releasees from any liability, claims, demands, damages, costs, expenses and
attorneys’ fees incurred as a result of any such assignment or transfer from Executive. 

3.    Severability. In the event any provision of this Release is found to be unenforceable by an arbitrator or
court of competent jurisdiction, such provision shall be deemed modified to the extent necessary to allow enforceability of the provision as so limited, it being intended that the 

  
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parties shall receive the benefit contemplated herein to the fullest extent permitted by law. If a deemed modification is not satisfactory in the judgment of such arbitrator or court, the
unenforceable provision shall be deemed deleted, and the validity and enforceability of the remaining provisions shall not be affected thereby. 

4.    Interpretation; Construction. The headings set forth in this Release are for convenience only and shall not
be used in interpreting this Agreement. This Release has been drafted by legal counsel representing the Company, but Executive has participated in the negotiation of its terms. Furthermore, Executive acknowledges that Executive has had an
opportunity to review and revise the Release and have it reviewed by legal counsel, if desired, and, therefore, the normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in
the interpretation of this Release. Either party’s failure to enforce any provision of this Release shall not in any way be construed as a waiver of any such provision, or prevent that party thereafter from enforcing each and every other
provision of this Release. 
 5.    Governing Law and Venue. This Release will be governed by and construed in
accordance with the laws of the United States of America and the State of New York applicable to contracts made and to be performed wholly within such State, and without regard to the conflicts of laws principles thereof. Any suit brought hereon
shall be brought in the state or federal courts sitting in New York, New York, the Parties hereby waiving any claim or defense that such forum is not convenient or proper. Each party hereby agrees that any such court shall have in personam
jurisdiction over it and consents to service of process in any manner authorized by New York law. 
 6.    Entire
Agreement. This Release and the Agreement constitute the entire agreement of the Parties in respect of the subject matter contained herein and therein and supersede all prior or simultaneous representations, discussions, negotiations and
agreements, whether written or oral. This Release may be amended or modified only with the written consent of Executive and an authorized representative of the Company. No oral waiver, amendment or modification will be effective under any
circumstances whatsoever. 
 7.    Counterparts. This Release may be executed in multiple counterparts, each of
which shall be deemed to be an original but all of which together shall constitute one and the same instrument. 
 (Signature Page Follows)

  
 4 

 IN WITNESS WHEREOF, and intending to be legally bound, the Parties have executed the
foregoing Release as of the date first written above. 
  

							
	EXECUTIVE	 		 	ZENO MANAGEMENT, INC.
				
	      
	 	                                	 	By:	 	      

	Print Name: Anthony Y. Sun, M.D.	 		 	Print Name:	 	      

		 		 	Title:

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