Document:

EX-4.7

 Exhibit 4.7 

Execution Version 

AVALANCHE BIOTECHNOLOGIES, INC. 

AMENDED AND RESTATED VOTING AGREEMENT 

THIS AMENDED AND RESTATED VOTING AGREEMENT
(the “Agreement”) is made and entered into as of this 16th day of April, 2014, by and among Avalanche Biotechnologies, Inc., a Delaware corporation (the “Company”), those certain holders of the
Company’s Common Stock listed on Exhibit A hereto (the “Key Holders”) and the holders of the Company’s Series A Preferred Stock (the “Series A Preferred Stock”) and Series B
Preferred Stock (the “Series B Preferred Stock” and collectively with the Series A Preferred Stock, the “Preferred Stock”) listed on Exhibit B hereto (the
“Investors”). 
 WITNESSETH 

WHEREAS, the Key Holders are the beneficial owners of an aggregate of three million one hundred thousand
(3,100,000) shares of the common stock of the Company (the “Common Stock”); 

WHEREAS, certain of the Investors are purchasing shares of the Company’s Series B Preferred
Stock pursuant to that certain Series B Preferred Stock Purchase Agreement (the “Purchase Agreement”) of even date herewith (the “Financing”);  

WHEREAS, the Company and the holders of Series A Preferred Stock have previously entered into that
certain Voting Agreement dated as of September 7, 2010 (the “Prior Agreement”) and desire to amend and restate the Prior Agreement and to accept the rights created pursuant hereto in lieu of the rights created under the
Prior Agreement; 
 WHEREAS, the obligations in the Purchase Agreement are conditioned upon the
execution and delivery of this Agreement;  
 WHEREAS, pursuant to Section 3.5 of the Prior
Agreement, the Prior Agreement may be amended or modified (or provisions of this Agreement waived) only upon the written consent of (i) the Company, (ii) holders of a majority of the Series A Preferred Stock and (iii) holders of a
majority of the Key Holder Shares (as defined in the Prior Agreement) held by Key Holders (as defined in the Prior Agreement) then providing services to the Company as officers or employees (the “Prior Agreement Amendment
Requirement”); and 
 WHEREAS, the execution of this Agreement by the Company and the
undersigned Stockholders satisfies the Prior Agreement Amendment Requirement. 
 NOW,
THEREFORE, in consideration of these premises and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

 AGREEMENT 
  

	1.	VOTING. 

 1.1 Key Holder Shares; Investor Shares. 

(a) The Key Holders each agree to hold all shares of voting capital stock of the Company registered in their respective names or
beneficially owned by them as of the date hereof and any and all other securities of the Company legally or beneficially acquired by each of the Key Holders after the date hereof (hereinafter collectively referred to as the “Key Holder
Shares”) subject to, and to vote the Key Holder Shares in accordance with, the provisions of this Agreement. 

(b) The Investors each agree to hold all shares of voting capital stock of the Company (including but not limited to all shares of
Common Stock issued or issuable upon conversion of the Preferred Stock) registered in their respective names or beneficially owned by them as of the date hereof and any and all other securities of the Company legally or beneficially acquired by each
of the Investors after the date hereof (hereinafter collectively referred to as the “Investor Shares”) subject to, and to vote the Investor Shares in accordance with, the provisions of this Agreement. 

1.2 Election of Directors. On all matters relating to the election and removal of directors of the Company, the Key Holders and the
Investors agree to vote all Key Holder Shares and Investor Shares held by them (or the holders thereof shall consent pursuant to an action by written consent of the holders of capital stock of the Company) so as to elect members of the
Company’s Board of Directors as follows: 
 (a) At each election of or action by written consent to elect directors in
which the holders of Preferred Stock, voting as a separate class, are entitled to elect directors of the Company, the Investors shall vote all of their respective Investor Shares so as to elect one individual designated by the holders of a majority
of the Series A Preferred Stock, which individual shall initially be Steven D. Schwartz (the “Series A Designee”). Any vote taken to remove any director elected pursuant to this Section 1.2(a), or to fill any
vacancy created by the resignation, removal or death of a director elected pursuant to this Section 1.2(a), shall also be subject to the provisions of this Section 1.2(a). Upon the request of any party entitled to designate a
director as provided in this Section 1.2(a), each Investor agrees to vote its Investor Shares for the removal of such director.  

(b) At each election of directors in which the holders of Common Stock, voting as a separate class, are entitled to elect directors of
the Company, the Key Holders and the Investors shall vote all of their respective Key Holder Shares and Investor Shares (to the extent converted to Common Stock) so as to elect: (i) the person serving as Chief Executive Officer of the Company,
which individual shall initially be Thomas W. Chalberg, Jr. and (ii) one (1) individual designated by the holders of a majority of Common Stock held by Key Holders who are then providing services to the Company as officers or employees, if
any, which individual shall initially be Mark S. Blumenkranz (together, the “Common Designees”). Any vote taken to remove any director elected pursuant to this Section 1.2(b), or to fill any vacancy created by the
resignation, removal or death of a director elected pursuant to this Section 1.2(b), shall also be subject to the provisions of this Section 1.2(b). In the event that the person serving as the director 

  
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to be elected as set forth in Section 1.2(b)(i) ceases to serve as the Chief Executive Officer of the Company, each Key Holder agrees to vote its Key Holder Shares for the removal of
such director at the request of a majority of the Board of Directors excluding the director to be removed. 
 1.3 No Liability for
Election of Recommended Director. None of the parties hereto and no officer, director, stockholder, partner, employee or agent of any party makes any representation or warranty as to the fitness or competence of the nominee of any party
hereunder to serve on the Board of Directors by virtue of such party’s execution of this Agreement or by the act of such party in voting for such nominee pursuant to this Agreement. 

1.4 Legend. 
 (a)
Concurrently with the execution of this Agreement, there shall be imprinted or otherwise placed, on certificates representing the Key Holder Shares and the Investor Shares the following restrictive legend (the “Legend”):

 “THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO THE TERMS AND CONDITIONS OF A VOTING AGREEMENT WHICH PLACES CERTAIN
RESTRICTIONS ON THE VOTING OF THE SHARES REPRESENTED HEREBY. ANY PERSON ACCEPTING ANY INTEREST IN SUCH SHARES SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE PROVISIONS OF SUCH AGREEMENT. A COPY OF SUCH VOTING AGREEMENT WILL BE
FURNISHED TO THE RECORD HOLDER OF THIS CERTIFICATE WITHOUT CHARGE UPON WRITTEN REQUEST TO THE COMPANY AT ITS PRINCIPAL PLACE OF BUSINESS.” 

(b) The Company agrees that, during the term of this Agreement, it will not remove, and will not permit to be removed (upon registration of
transfer, reissuance of otherwise), the Legend from any such certificate and will place or cause to be placed the Legend on any new certificate issued to represent Key Holder Shares or Investor Shares theretofore represented by a certificate
carrying the Legend. If at any time or from time to time any Key Holder or Investor holds any certificate representing shares of the Company’s capital stock not bearing the aforementioned legend, such Key Holder or Investor agrees to deliver
such certificate to the Company promptly to have such legend placed on such certificate. 
 1.5 Successors. The provisions of this
Agreement shall be binding upon the successors in interest to any of the Key Holder Shares or Investor Shares. The Company shall not permit the transfer of any of the Key Holder Shares or Investor Shares on its books or issue a new certificate
representing any of the Key Holder Shares or Investor Shares unless and until the person to whom such security is to be transferred shall have executed a written agreement, substantially in the form of this Agreement, pursuant to which such person
becomes a party to this Agreement and agrees to be bound by all the provisions hereof as if such person were a Key Holder or Investor, as applicable. 

  
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 1.6 Other Rights. Except as provided by this Agreement or any other agreement entered into
in connection with the Financing, each Key Holder and Investor shall exercise the full rights of a holder of capital stock of the Company with respect to the Key Holder Shares and the Investor Shares, respectively. 

1.7 Irrevocable Proxy. To secure the Key Holder’s and the Investor’s obligations to vote the Key Holder Shares and the
Investor Shares in accordance with this Agreement, each Key Holder and each Investor hereby appoints the Chairman of the Board of Directors or the Chief Executive Officer of the Company, or either of them from time to time, or their designees, as
such Key Holder’s or Investor’s true and lawful proxy and attorney, with the power to act alone and with full power of substitution, to vote all of such Key Holder’s Key Holder Shares or such Investor’s Investor Shares as set
forth in this Agreement and to execute all appropriate instruments consistent with this Agreement on behalf of such Key Holder or Investor if, and only if, such Key Holder or Investor fails to vote all of such Key Holder’s Key Holder Shares or
such Investor’s Investor Shares or execute such other instruments in accordance with the provisions of this Agreement within five (5) days of the Company’s or any other party’s written request for such Key Holder’s or
Investor’s written consent or signature. The proxy and power granted by each Key Holder and Investor pursuant to this Section are coupled with an interest and are given to secure the performance of such party’s duties under this Agreement.
Each such proxy and power will be irrevocable for the term hereof. The proxy and power, so long as any party hereto is an individual, will survive the death, incompetency and disability of such party or any other individual holder of the Investor
Shares or the Key Holder Shares, as the case may be, and, so long as any party hereto is an entity, will survive the merger or reorganization of such party or any other entity holding any Investor Shares or Key Holder Shares. 

1.8 No “Bad Actor” Disqualification.  

(a) The Company represents and warrants that it has exercised reasonable care to determine whether any Company Covered Person (as
defined below) is subject to any of the “bad actor” disqualifications described in Rule 506(d)(1)(i) through (viii), as modified by Rules 506(d)(2) and (d)(3), under the Securities Act of 1934, as amended (the “Securities
Act”) (“Disqualification Events”). To the Company’s knowledge, no Company Covered Person is subject to a Disqualification Event. The Company has complied, to the extent required, with any disclosure
obligations under Rule 506(e) under the Securities Act. For purposes of this Agreement, “Company Covered Persons” are those persons specified in Rule 506(d)(1) under the Securities Act. 

(b) Each Investor and each Key Holder (each, a “Voting Party”) on behalf of itself represents and warrants, severally
and not jointly, and to the Company only, that neither (i) such person, nor (ii) any entity that is an affiliate of such person, nor (iii) any director of the Company that has been designated by such person, is subject to any
Disqualification Event (as defined in Section 1.8(a) above), except for Disqualification Events covered by Rule 506(d)(2)(i), (ii) or (iii) or (d)(3) under the Securities Act and disclosed in writing in reasonable detail to the
Company. No party to this Agreement entitled to designate a director of the Company under Section 2 hereof shall designate a director that is subject to any Disqualification Event, except for Disqualification Events covered by Rule
506(d)(2)(i), (ii) or (iii) or (d)(3) under the Securities Act, in which case such party will promptly disclose in writing to the Company and other parties to this Agreement any and all information necessary for the Company to determine
whether Rule 506(d)(2)(i), (ii) or (iii) or (d)(3) applies. 

  
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 (c) Each party to this Agreement represents, severally and not jointly and to the
Company only, that it has exercised reasonable care to determine the accuracy of the representation made by it in either Sections 1.8(a) or 1.8(b) as applicable, and agrees to notify the Company if it becomes aware of any fact that
makes the representation given by it hereunder inaccurate. 
 (d) Notwithstanding any other provision in this Agreement to
the contrary, no party to this Agreement will be required to vote for any director or proposed director who is subject to a Disqualification Event, except for Disqualification Events covered by Rule 506(d)(2)(i), (ii) or (iii) or (d)(3)
under the Securities Act. 
 (e) The agreements under this Section 1.8 between the Company and each Voting Party are
separate agreements and no Voting Party or any affiliate thereof (other than the Company) shall be directly liable to any other Voting Party under this Section 1.8. 
  

	2.	TERMINATION. 

 2.1 This Agreement shall continue in full force and
effect from the date hereof through the earliest of the following dates, on which date it shall terminate in its entirety: 
 (a) the
date of the closing of a firmly underwritten public offering of the Common Stock pursuant to a registration statement filed with the Securities and Exchange Commission, and declared effective under the Securities Act that results in the Preferred
Stock being converted into Common Stock; 
 (b) ten (10) years from the date of this Agreement. 

(c) the date of the closing of an Acquisition, as defined in the Company’s Certificate of Incorporation as in effect as of the date
hereof; or 
 (d) the date as of which the parties hereto terminate this Agreement by written consent of the holders of a majority of the
Series A Preferred Stock, the holders of a majority of the Series B Preferred Stock and the Key Holders holding a majority of the Key Holder Shares who are then providing services to the Company as officers or employees. 

 

	3.	MISCELLANEOUS. 

 3.1 Ownership. Each Key Holder represents and
warrants to the Investors and the Company that (a) such Key Holder now owns the Key Holder Shares listed on Exhibit A hereto, free and clear of liens or encumbrances, and has not, prior to or on the date of this Agreement, executed
or delivered any proxy or entered into any other voting agreement or similar arrangement other than one which has expired or terminated prior to the date hereof, and (b) such Key Holder has full power and capacity to execute, deliver and
perform this Agreement, which has been duly executed and delivered by, and evidences the valid and binding obligation of, such Key Holder enforceable in accordance with its terms. Each Investor represents and warrants to 

  
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the Investors and the Company that (a) such Investor now owns, or will own upon the Closing (as defined in the Purchase Agreement), the Investor Shares listed on Exhibit B
hereto, free and clear of liens or encumbrances, and has not, prior to or on the date of this Agreement, executed or delivered any proxy or entered into any other voting agreement or similar arrangement other than one which has expired or terminated
prior to the date hereof, and (b) such Investor has full power and capacity to execute, deliver and perform this Agreement, which has been duly executed and delivered by, and evidences the valid and binding obligation of, such Investor
enforceable in accordance with its terms. 
 3.2 Further Action. If and whenever any Key Holder Shares are sold, the Key Holders or
the personal representative of the Key Holders shall do all things and execute and deliver all documents and make all transfers, and cause any transferee of the Key Holder Shares to do all things and execute and deliver all documents, as may be
necessary to consummate such sale consistent with this Agreement. 
 3.3 Specific Performance. The parties hereto hereby
declare that it is impossible to measure in money the damages which will accrue to a party hereto or to their heirs, personal representatives, or assigns by reason of a failure to perform any of the obligations under this Agreement and agree that
the terms of this Agreement shall be specifically enforceable. If any party hereto or his heirs, personal representatives, or assigns institutes any action or proceeding to specifically enforce the provisions hereof, any person against whom such
action or proceeding is brought hereby waives the claim or defense therein that such party or such personal representative has an adequate remedy at law, and such person shall not offer in any such action or proceeding the claim or defense that such
remedy at law exists. 
 3.4 Governing Law. This Agreement shall be governed by and construed under the laws of the State of
Delaware as such laws are applied to agreements among Delaware residents entered into and performed entirely within the State of Delaware, without reference to the conflict of laws provisions thereof. The parties agree that any action brought by
either party under or in relation to this Agreement, including without limitation to interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to and does hereby submit to the jurisdiction and venue of, any
state or federal court located in the County of Santa Clara, California. THE PARTIES TO THIS AGREEMENT HEREBY WAIVE THEIR RIGHT TO A TRIAL BY JURY WITH RESPECT TO DISPUTES ARISING UNDER THIS AGREEMENT AND CONSENT TO A BENCH TRIAL WITH THE
APPROPRIATE JUDGE ACTING AS THE FINDER OF FACT. 
 3.5 Amendment or Waiver. This Agreement may be amended or modified (or provisions
of this Agreement waived) only upon the written consent of (i) the Company, (ii) holders of a majority of the Series A Preferred Stock; (iii) holders of a majority of the Series B Preferred Stock; and (iv) holders of a majority
of the Key Holder Shares held by Key Holders then providing services to the Company as officers or employees. Any amendment or waiver so effected shall be binding upon the Company, each of the parties hereto and any assignee of any such party.
Notwithstanding the foregoing, Section 1.2 of this Agreement may be amended to add additional holders of Common Stock or Preferred Stock as Key Holders or Investors hereunder by an instrument in writing signed by the Company and such
holders. Notwithstanding the foregoing, any amendment, modification or waiver that adversely affects the rights of an Investor in a manner that is materially different than the effect on the rights of the other Investors shall also require the
written consent of such adversely affected Investor. 

  
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 3.6 Severability. In the event one or more of the provisions of this Agreement should, for
any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if such invalid, illegal or
unenforceable provision had never been contained herein. 
 3.7 Successors and Assigns. The provisions hereof shall inure to
the benefit of, and be binding upon, the parties hereto and their respective successors, assigns, heirs, executors and administrators and other legal representatives. 

3.8 Additional Shares. In the event that subsequent to the date of this Agreement any shares or other securities are issued on, or in
exchange for, any of the Key Holder Shares or Investor Shares by reason of any stock dividend, stock split, combination of shares, reclassification or the like, such shares or securities shall be deemed to be Key Holder Shares or Investor Shares, as
the case may be, for purposes of this Agreement. 
 3.9 Additional Investors. Notwithstanding anything to the contrary
contained herein, if the Company shall issue additional shares of its Preferred Stock pursuant to the Purchase Agreement, any purchaser of such shares of Preferred Stock shall become a party to this Agreement by executing and delivering an
additional counterpart signature page to this Agreement and shall be deemed an Investor and a party hereunder. 
 3.10
Counterparts. This Agreement may be executed in one or more counterparts, each of which will be deemed an original, but all of which together shall constitute one instrument. 

3.11 Waiver. No waivers of any breach of this Agreement extended by any party hereto to any other party shall be construed as a waiver
of any rights or remedies of any other party hereto or with respect to any subsequent breach. 
 3.12 Delays or Omissions. It
is agreed that no delay or omission to exercise any right, power or remedy accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power or remedy, nor shall it be construed
to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of or in any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent or approval of any kind or
character on any party’s part of any breach, default or noncompliance under this Agreement or any waiver on such party’s part of any provisions or conditions of the Agreement must be in writing and shall be effective only to the extent
specifically set forth in such writing. All remedies, either under this Agreement by law, or otherwise afforded to any party, shall be cumulative and not alternative. 

3.13 Attorney’s Fees. In the event that any suit or action is instituted under or in relation to this Agreement, including without
limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with respect to this
Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

  
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 3.14 Notices. All notices required in connection with this Agreement shall be in writing
and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business
day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day
delivery, with written notification of receipt. All communications shall be sent to the party to be notified at the address as set forth on the signature pages hereof or Exhibit A or Exhibit B hereto or at such other address or
electronic mail address as such party may designate by ten (10) days advance written notice to the other parties hereto. 
 3.15
Entire Agreement. This Agreement and the Exhibits hereto, along with the Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the
subjects hereof and thereof and no party shall be liable or bound to any other in any manner by any oral or written representations, warranties, covenants and agreements except as specifically set forth herein and therein. Each party expressly
represents and warrants that it is not relying on any oral or written representations, warranties, covenants or agreements outside of this Agreement. The Prior Agreement is hereby amended in its entirety and restated herein, and all provisions of,
rights granted and covenants made in the Prior Agreement are hereby waived, released and superseded in their entirety and shall have no further force or effect. 

[THIS SPACE INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED VOTING AGREEMENT as of the date first above written. 

 

			
	COMPANY:
	
	AVALANCHE BIOTECHNOLOGIES, INC.
		
	Signature:	 	 /s/ Tom Chalberg

		
	Print Name:	 	Thomas W. Chalberg, Jr.
		
	Title:	 	President and Chief Executive Officer
		
	Address:	 	1035 O’Brien Drive
		 	Menlo Park, CA 94025
		 	Attention: Chief Executive Officer
		
		 	with a copy (which shall not constitute notice) to:
		
		 	 Latham & Watkins LLP
 140 Scott Drive

Menlo Park, California 94025
 Attn: Alan C. Mendelson,
Esq.

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTORS:
	
	VENROCK ASSOCIATES VI, L.P.
	By:	 	Venrock Management VI, LLC
	Its:	 	General Partner
	
	VENROCK PARTNERS VI, L.P.
	By:	 	Venrock Partners Management VI, LLC
	Its:	 	General Partner
		
	By:	 	 /s/ David Stepp

		 	Authorized Signatory
	
	VENROCK HEALTHCARE CAPITAL PARTNERS, L.P.
	By:	 	VHCP Management, LLC
	Its:	 	General Partner
	
	VHCP CO-INVESTMENT HOLDINGS, LLC
	By:	 	VHCP Management, LLC
	Its:	 	Manager
		
	By:	 	 /s/ David Stepp

		 	Authorized Signatory

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	ZYGTECH, LLC, A NEW JERSEY LIMITED LIABILITY COMPANY
		
	By:	 	 /s/ Zygmunt Wilf

	Name:	 	Zygmunt Wilf
		
	Title:	 	 Member

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	RICHARD AND MARCIA SCHULMAN LIVING TRUST DATED 10/2/99
		
	By:	 	 /s/ Richard Schulman

		
	Name:	 	 Richard Schulman

		
	Title:	 	 Co-Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	ROBERTA S. HOLLAND REVOCABLE TRUST-1996, DATED 10/28/96 AS AMENDED
		
	By:	 	 /s/ Roberta S. Holland

		
	Name:	 	 Roberta S. Holland Revocable Trust - 1996

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	PENSCO TRUST COMPANY CUSTODIAN (JOSEPH OLIVEIRA), IRA 080000004747
		
	By:	 	 /s/ Joseph Oliveira

		
	Name:	 	 Joseph Oliveira

		
	Title:	 	  

	
	PENSCO TRUST COMPANY FBO
	
	 Joseph Oliveira

	Authorized Signer
		
	By:	 	 /s/ Rachel Wheeler

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	REGENERON PHARMACEUTICALS, INC.
		
	By:	 	 /s/ Joseph J. LaRosa

		
	Name:	 	 Joseph J. LaRosa

		
	Title:	 	 SVP, General Counsel & Secretary

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

					
	INVESTOR:
	
	COWEN AV INVESTMENT LLC
		
	By:	 	Cowen Structured Holdings Inc., it’s managing member
		
	By:	 	 /s/ Stephen Lasota

			
		 	 Name:
	 	Stephen Lasota
			
		 	 Title:
	 	Chief Financial Officer
		 		 	Cowen Group, Inc.

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTORS:
	
	REDMILE CAPITAL FUND, LP
	
	 /s/ Jeremy Green

	By.	 	Jeremy Green
	Title:	 	Managing Member of the General Partner and the Investment Manager
	
	REDMILE CAPITAL OFFSHORE FUND, LTD.
	
	 /s/ Jeremy Green

	By.	 	Jeremy Green
	Title:	 	Managing Member of the Investment Manager
	
	REDMILE CAPITAL OFFSHORE FUND II, LTD.
	
	 /s/ Jeremy Green

	By.	 	Jeremy Green
	Title:	 	Managing Member of the Investment Manager
	
	REDMILE SPECIAL OPPORTUNITIES FUND, LTD.
	
	 /s/ Jeremy Green

	By.	 	Jeremy Green
	Title:	 	Managing Member of the Investment Manager

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

							
	INVESTOR:
	
	SABBY HEALTHCARE VOLATILITY MASTER FUND, LTD.
		
	By:	 	Sabby Management, LLC, its Investment Manager
				
		 		 	By:	 	 /s/ Robert Grundstein

		 		 		 	Robert Grundstein, COO and General Counsel

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	ADAGE CAPITAL PARTNERS, LP
	BY:	 	Adage Capital Partners, GP, LLC, it’s General Partner
	BY:	 	Adage Capital Advisors, LLC it’s Managing Member
		
	By:	 	 /s/ Phillip T. Gross

		
	Name:	 	 Phillip T. Gross

		
	Title:	 	 Managing Director

 Adage Capital Partners, GP, LLC (“ACPGP”), serves as the general partner of Adage Capital Partners, LP, a Delaware
limited partnership (the “Fund”) and as such has discretion over the portfolio of securities beneficially owned by the Fund. Adage Capital Advisors, LLC, a Delaware limited liability company (“ACA”), is managing member of
ACPGP and directs ACPGP’s operations. Robert Atchinson and Phillip Gross are the managing members of ACPGP and ACA and general partners of the Fund. Robert Atchinson and Phillip Gross disclaim beneficial ownership of the reported
securities except to the extent of their pecuniary interest therein. 

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTORS:
	
	T. ROWE PRICE HEALTH SCIENCES FUND, INC.
	TD MUTUAL FUNDS – TD HEALTH SCIENCES FUND
	VALIC COMPANY I – HEALTH SCIENCES FUND
	T. ROWE PRICE HEALTH SCIENCES PORTFOLIO
	JOHN HANCOCK VARIABLE INSURANCE TRUST – HEALTH SCIENCES TRUST
	JOHN HANCOCK FUNDS II – HEALTH SCIENCES FUND
		
	By: 	 	T. Rowe Price Associates, Inc., Investment Adviser
		
	By: 	 	 /s/ Taymour Tamaddon

		
	Name:	 	 Taymour Tamaddon

		
	Title:	 	 Vice President

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

									
	INVESTORS:
	
	DEERFIELD SPECIAL SITUATIONS FUND, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
		 	 By:
	 	J.E. Flynn Capital, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory
	
	DEERFIELD SPECIAL SITUATIONS INTERNATIONAL MASTER FUND, L.P.
	By:	 	Deerfield Mgmt, L.P.
		 	General Partner
		 	 By:
	 	J.E. Flynn Capital, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory
	
	DEERFIELD PRIVATE DESIGN FUND III, L.P.
	By:	 	Deerfield Mgmt III, L.P.
		 	General Partner
		 	 By:
	 	J.E. Flynn Capital III, LLC
		 		 	General Partner
				
		 		 	By:	 	 /s/ David J. Clark

		 		 		 	Name:	 	David J. Clark
		 		 		 	Title:	 	Authorized Signatory

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	 INVESTORS:

	
	 FIDELITY SECURITIES FUND: FIDELITY OTC
PORTFOLIO

		
	By:	 	 /s/ Stacie M. Smith

		
	Name:	 	 Stacie Smith

		
	Title:	 	 Deputy Treasurer

	
	 FIDELITY SELECT PORTFOLIOS: BIOTECHNOLOGY
PORTFOLIO

		
	By:	 	 /s/ Stacie M. Smith

		
	Name:	 	 Stacie Smith

		
	Title:	 	 Deputy Treasurer

	
	 FIDELITY ADVISOR SERIES VII: FIDELITY ADVISOR
BIOTECHNOLOGY FUND

		
	By:	 	 /s/ Stacie M. Smith

		
	Name:	 	 Stacie Smith

		
	Title:	 	 Deputy Treasurer

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	ROCK SPRINGS CAPITAL MASTER FUND LP
	By:	 	Rock Springs GP LLC
	Its:	 	General Partner
		
	By:	 	 /s/ Jeffrey Annecchino

		
	Name:	 	 Jeffrey Annecchino

		 	Authorized Signatory
		
	Title:	 	 COO

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	WACHTER FAMILY TRUST
		
	By:	 	 /s/ Paul Wachter

		
	Name:	 	 Paul Wachter

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Alexandre Cohen

	ALEXANDRE COHEN

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	GREGORY D SNODGRASS & KATHLEEN M SNODGRASS TTEES OF THE GREGORY AND KATHLEEN
SNODGRASS LIVING TRUST DTD 12/13/00
		
	By:	 	 /s/ Gregory D. Snodgrass

		
	Name:	 	 Gregory D. Snodgrass

		
	Title:	 	 Trustee

		
	By:	 	 /s/ Kathleen M. Snodgrass

		
	Name:	 	 Kathleen M. Snodgrass

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Stonington Cox

	STONINGTON COX

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	CONSTANCE C COX TRUST DATED JUNE 28, 2000 AS AMENDED
		
	By:	 	 /s/ Constance C. Cox

		
	Name:	 	 Constance C. Cox, Trust dated June 28, 2000 as amended

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	P. ANTHONY PRICE REVOCABLE TRUST, MAY 6, 2002
		
	By:	 	 /s/ P.A. Price

		
	Name:	 	 P. Anthony Price

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	KRISTEN AND JIM WELLS FAMILY TRUST
		
	By:	 	 /s/ Kristen Wells

		
	Name:	 	 Kristen Wells

		
	Title:	 	 Trustee

		
	By:	 	 /s/ Jim Wells

		
	Name:	 	 Jim Wells

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Johannes Hull

	JOHANNES HULL

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Michael C. Clark

	MICHAEL CLARK

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Herman L. Alcalde

	HERMAN ALCALDE

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ John McLaughlin

	JOHN MCLAUGHLIN

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	RIVERBEND RANCH PENSION TRUST
		
	By:	 	 /s/ Donald Ozenbaugh

		
	Name:	 	 Donald Ozenbaugh

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	ALAN C. & AGNÈS B. MENDELSON FAMILY TRUST
		
	By:	 	 /s/ Alan C. Mendelson

	Name:	 	Alan C. Mendelson
	Title:	 	Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	VP COMPANY INVESTMENTS 2008, LLC
		
	By:	 	 /s/ Alan C. Mendelson

	Name:	 	Alan C. Mendelson
	Title:	 	Member of Management Committee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

			
	INVESTOR:
	
	 GREGORY P CHAGARIS & ANTHEA C STRATIGOS TTEE

CHAGARIS STRATIGOS FAM REV TST

		
	By:	 	 /s/ Gregory P. Chagaris

		
	Name:	 	 Gregory P. Chagaris

		
	Title:	 	 Trustee

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	INVESTOR:
	
	 /s/ Jordan Dubnow

	JORDAN DUBNOW

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	KEY HOLDER:
	
	 /s/ Tom Chalberg

	THOMAS W. CHALBERG, JR.

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	KEY HOLDER:
	
	 /s/ Mark S. Blumenkranz

	MARK S. BLUMENKRANZ

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	KEY HOLDER:
	
	 /s/ Steven D. Schwartz

	STEVEN D. SCHWARTZ

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

	
	KEY HOLDER:
	
	 /s/ Mitchell H. Finer

	MITCHELL H. FINER

  
 AMENDED AND
RESTATED VOTING AGREEMENT 
 SIGNATURE PAGE 

 EXHIBIT A 

LIST OF KEY HOLDERS 
 Thomas W. Chalberg,
Jr. 
 Mark S. Blumenkranz 
 Steven D. Schwartz 

Mitchell Finer 

  
 LIST OF KEY HOLDERS

 EXHIBIT B 

LIST OF INVESTORS 
 Zygtech, LLC, a New
Jersey Limited Liability Company 
 820 Morris Turnpike, Suite 301 

Short Hills, NJ 07078 
 Carla Helene Blumenkranz
Irrevocable Trust 
 20 Larguita Lane 

Portola Valley, CA 94028 
 Scott Aubrey
Blumenkranz Irrevocable Trust 
 20 Larguita Lane 

Portola Valley, CA 94028 
 Erik Davis Blumenkranz
Irrevocable Trust 
 20 Larguita Lane 

Portola Valley, CA 94028 
 Marty G. Glick 

511 Hampton Road 
 Piedmont, CA
94611 
 Thomas W. Chalberg, Jr. 
 2749
Carolina Avenue 
 Redwood City, CA 94061 

Mark S. Blumenkranz 
 20 Larguita Lane 

Portola Valley, CA 94028 
 Steven D. Schwartz

 10801 W. Sunset Blvd. 
 Los
Angeles, CA 90077 
 Mitchell Finer 
 150
Whitman Street 
 Stow, MA 01775 
 Richard and
Marcia Schulman Living Trust dated 10/2/99 
 10750 Wilshire Boulevard, #1401 

Los Angeles, CA 90024 

  
 LIST OF INVESTORS

 Roberta S. Holland, Trustee of the Roberta S. Holland Revocable Trust-1996, dated 10/28/96 as amended 

10800 Wilshire Blvd. #1404 
 Los
Angeles, CA 90024 
 Pensco Trust Company Custodian (Joseph Oliveira), IRA 080000004747 

409 Albasio Ct. 
 Angels Camp, CA
95222-9756 
 Venrock Healthcare Capital Partners, L.P. 

3340 Hillview Avenue 
 Palo Alto,
CA 94304 
 Attn: David Stepp 
 Venrock
Associates VI, L.P. 
 3340 Hillview Avenue 

Palo Alto, CA 94304 
 Attn: David
Stepp 
 Venrock Partners VI, L.P. 
 3340
Hillview Avenue 
 Palo Alto, CA 94304 

Attn: David Stepp 
 VHCP Co-Investment Holdings,
LLC 
 3340 Hillview Avenue 

Palo Alto, CA 94304 
 Attn: David
Stepp 
 Regeneron Pharmaceuticals, Inc. 
 777
Old Saw Mill River Road 
 Tarrytown, NY 10591 

Attention: President 
 Copy:
General Counsel 
 Cowen AV Investment LLC 

599 Lexington Ave 
 New York, NY
10022 
 Redmile Capital Fund, LP 
 c/o Redmile
Group, LLC 
 One Letterman Drive, Bldg. D, Suite D3-700 

San Francisco, CA 94129 

  
 LIST OF INVESTORS

 Redmile Capital Offshore Fund, Ltd. 

c/o Redmile Group, LLC 
 One
Letterman Drive, Bldg. D, Suite D3-700 
 San Francisco, CA 94129 

Redmile Capital Offshore Fund II, Ltd. 
 c/o
Redmile Group, LLC 
 One Letterman Drive, Bldg. D, Suite D3-700 

San Francisco, CA 94129 
 Redmile Special
Opportunities Fund, Ltd. 
 c/o Redmile Group, LLC 

One Letterman Drive, Bldg. D, Suite D3-700 

San Francisco, CA 94129 
 Sabby Healthcare
Volatility Master Fund, Ltd. 
 c/o Sabby Management, LLC 

10 Mountainview Road, suite 205 

Upper Saddle River, NJ 07458 
 Adage Capital
Partners 
 200 Clarendon St. 52nd floor 

Boston, MA 02116 
 Lobstercrew & Co. fbo
T. Rowe Price Health Sciences Fund, Inc. 
 T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

Mac & Co. fbo TD Mututal Funds - TD Health Sciences Fund 

T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

Squidrig & Co. fbo VALIC Company I - Health Sciences Fund 

T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

Horizon Beach & Co. fbo T. Rowe Price Health Sciences Portfolio 

T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

  
 LIST OF INVESTORS

 Lamppost & Co. fbo John Hancock Variable Insurance Trust - Health Sciences Trust 

T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

ANNUITANT & CO. fbo John Hancock Funds II - Health Sciences Fund 

T. Rowe Price Associates, Inc. 

100 East Pratt Street 
 Baltimore,
MD 21202 
 Attn: Andrew Baek, Vice President and Senior Legal Counsel 

Deerfield Special Situations Fund, L.P. 
 780 3rd
ave 37th Floor 
 New York, NY 10017 

Deerfield Special Situations International Master Fund, L.P. 

780 3rd ave 37th Floor 
 New York,
NY 10017 
 Deerfield Private Design Fund III, L.P.

780 3rd ave 37th Floor 
 New York,
NY 10017 
 Booth & Co fbo Fidelity Securities Fund: Fidelity OTC Portfolio 

The Northern Trust Company 
 Attn:
Trade Securities Processing, C-1N 
 801 South Canal Street 

Chicago, IL 60607 
 Fidelity
Securities Fund: Fidelity OTC Portfolio 
 Reference Account # 26-68304 

Mag & Co fbo Fidelity Select Portfolios: Biotechnology Portfolio 

Brown Brothers Harriman & Co. 

525 Washington Blvd 
 Jersey City
NJ 07310 
 Attn: Michael Lerman 15th Floor 

Corporate Actions 
 Bangle & Co fbo
Fidelity Advisor Series VII: Fidelity Advisor Biotechnology Fund 
 State Street Bank & Trust 

PO Box 5756 
 Boston,
Massachusetts 02206 
 Attn: Bangle & Co fbo Fidelity Advisor Series VII: Fidelity Advisor Biotechnology Fund 

  
 LIST OF INVESTORS

 Rock Springs Capital Master Fund LP 

650 South Exeter Street 
 Suite
1070 
 Baltimore, MD 21202 
 Wachter Family
Trust 
 127 N. Cliffwood Ave. 

Los Angeles, CA 90049 
 Alexandre Cohen 

3110 Main Street, Suite #310 

Santa Monica, CA 90405 
 Gregory D
Snodgrass & Kathleen M Snodgrass TTEES of The Gregory and Kathleen Snodgrass Living Trust Dtd 12/13/00 
 2045 Tasso Street 

Palo Alto, CA 94301 
 Stonington Cox 

2240 Green St. Apt.3 
 San
Francisco, CA 94123 
 Constance C Cox Trust dated June 28, 2000 as amended 

2999 Pacific Ave., Apt 5 
 San
Francisco, CA 94115 
 P. Anthony Price Revocable Trust, May 6, 2002 

2999 Pacific Ave., Apt 5 
 San
Francisco, CA 94115 
 Kristen and Jim Wells Family Trust 

4115 Fair Oaks Ave 
 Menlo Park,
CA 94025 
 Johannes Hull 
 29 Dearborn Street

 San Francisco, CA 94110 
 Michael Clark 

1096 Clarendon Ct 
 Oakland, CA
94610 
 Herman Alcalde 
 3733 Erris Ct 

South San Francisco, CA 94080 

  
 LIST OF INVESTORS

 John McLaughlin 

265 Glen Way 
 Incline Village, NV
89451 
 Riverbend Ranch Pension Trust 
 630
Smith Flat Rd. 
 Angels Camp, CA 95222 
 Alan
C. & Agnès B. Mendelson Family Trust 
 76 De Bell Drive 

Atherton, CA 94027 
 VP Company Investments 2008,
LLC 
 c/o Latham & Watkins LLP 555 W. 5th Street Suite 800 

Los Angeles, CA 90013 
 GREGORY P
CHAGARIS & ANTHEA C STRATIGOS TTEE 
 CHAGARIS STRATIGOS FAM REV TST 

60 Joyce Road 
 Hillsborough, CA
94010 
 Jordan Dubnow 
 c/o Main Street
Advisors, Inc. 
 3110 Main Street, Suite #310 

Santa Monica, CA 90405 

  
 LIST OF INVESTORSEX-10.12

 Exhibit 10.12 

INDEMNIFICATION AGREEMENT 

This Indemnification Agreement (“Agreement”) is made as of
                    , 2014 by and between Avalanche Biotechnologies, Inc., a Delaware corporation (the “Company”), and
                     (“Indemnitee”). 

RECITALS 
 WHEREAS, highly
competent persons have become more reluctant to serve publicly-held corporations as directors or officers or in other capacities unless they are provided with adequate protection through insurance or adequate indemnification against inordinate risks
of claims and actions against them arising out of their service to and activities on behalf of the corporation; 
 WHEREAS, the Board of
Directors of the Company (the “Board”) has determined that, in order to attract and retain qualified individuals, the Company will attempt to maintain on an ongoing basis, at its sole expense, liability insurance to protect persons serving
the Company and its subsidiaries from certain liabilities. Although the furnishing of such insurance has been a customary and widespread practice among United States-based corporations and other business enterprises, the Company believes that, given
current market conditions and trends, such insurance may be available to it in the future only at higher premiums and with more exclusions. At the same time, directors, officers and other persons in service to corporations or business enterprises
are being increasingly subjected to expensive and time-consuming litigation relating to, among other things, matters that traditionally would have been brought only against the Company or business enterprise itself. The Bylaws (the
“Bylaws”) and the Certificate of Incorporation of the Company (the “Certificate of Incorporation”) require indemnification of the officers and directors of the Company. Indemnitee may also be entitled to indemnification pursuant
to the General Corporation Law of the State of Delaware (the “DGCL”). The Bylaws, the Certificate of Incorporation and the DGCL expressly provide that contracts may be entered into between the Company and members of the board of directors,
officers and other persons with respect to indemnification; 
 WHEREAS, the uncertainties relating to such insurance and to indemnification
have increased the difficulty of attracting and retaining such persons; 
 WHEREAS, the Board has determined that the increased difficulty
in attracting and retaining such persons is detrimental to the best interests of the Company and its stockholders and that the Company should act to assure such persons that there will be increased certainty of such protection in the future; 

WHEREAS, it is reasonable, prudent and necessary for the Company contractually to obligate itself to indemnify, and to advance expenses on
behalf of, such persons to the fullest extent permitted by applicable law so that they will serve or continue to serve the Company free from undue concern that they will not be so indemnified; 

 WHEREAS, this Agreement is a supplement to and in furtherance of the Bylaws, the Certificate of
Incorporation and any resolutions adopted pursuant thereto, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder; 

WHEREAS, Indemnitee does not regard the protection available under the Bylaws, the Certificate of Incorporation and insurance as adequate in
the present circumstances, and may not be willing to serve as an officer or director without adequate protection, and the Company desires Indemnitee to serve in such capacity. Indemnitee is willing to serve, continue to serve and to take on
additional service for or on behalf of the Company on the condition that he or she be so indemnified; and 
 NOW, THEREFORE, in
consideration of the premises and the covenants contained herein, the Company and Indemnitee do hereby covenant and agree as follows: 

Section 1. Services to the Company. Indemnitee agrees to serve as a director, officer, employee or agent of the Company, as
applicable, or, at the request of the Company, as a director, officer, employee, agent or fiduciary of another corporation, partnership, joint venture, trust or other enterprise, as applicable. Indemnitee may at any time and for any reason resign
from such position (subject to any other contractual obligation or any obligation imposed by operation of law), in which event the Company shall have no obligation under this Agreement to continue Indemnitee in such position. This Agreement shall
not be deemed an employment contract between the Company (or any of its subsidiaries or any Enterprise) and Indemnitee. Indemnitee specifically acknowledges that Indemnitee’s employment with the Company (or any of its subsidiaries or any
Enterprise), if any, is at will, and the Indemnitee may be discharged at any time for any reason, with or without cause, except as may be otherwise provided in any written employment contract between Indemnitee and the Company (or any of its
subsidiaries or any Enterprise), other applicable formal severance policies duly adopted by the Board, or, with respect to service as a director or officer of the Company, by the Certificate of Incorporation, the Bylaws and the DGCL. The foregoing
notwithstanding, this Agreement shall continue in force after Indemnitee has ceased to serve as a director, officer, employee or agent of the Company, as applicable, or, at the request of the Company, as a director, officer, employee, agent or
fiduciary of another corporation, partnership, joint venture, trust or other enterprise, as applicable, as provided in Section 16 hereof. 

Section 2. Definitions. As used in this Agreement: 

(a) References to “agent” shall mean any person who is or was a director, officer or employee of the Company or a subsidiary of the
Company or other person authorized by the Company to act for the Company, to include such person serving in such capacity as a director, officer, employee, fiduciary or other official of another corporation, partnership, limited liability company,
joint venture, trust or other enterprise at the request of, for the convenience of, or to represent the interests of the Company or a subsidiary of the Company. 

(b) A “Change in Control” shall be deemed to occur upon the earliest to occur after the date of this Agreement of any of the
following events: 

  
 2 

 i. Acquisition of Stock by Third Party. Any Person (as defined below) is or becomes the
Beneficial Owner (as defined below), directly or indirectly, of securities of the Company representing fifteen percent (15%) or more of the combined voting power of the Company’s then outstanding securities unless the change in relative
Beneficial Ownership of the Company’s securities by any Person results solely from a reduction in the aggregate number of outstanding shares of securities entitled to vote generally in the election of directors; 

ii. Change in Board of Directors. During any period of two (2) consecutive years (not including any period prior to the execution of
this Agreement), individuals who at the beginning of such period constitute the Board, and any new director (other than a director designated by a person who has entered into an agreement with the Company to effect a transaction described in
Sections 2(b)(i), 2(b)(iii) or 2(b)(iv)) whose election by the Board or nomination for election by the Company’s stockholders was approved by a vote of at least two-thirds (2/3) of the directors then still in office who either were
directors at the beginning of the period or whose election or nomination for election was previously so approved, cease for any reason to constitute at least a majority of the members of the Board; 

iii. Corporate Transactions. The effective date of a merger or consolidation of the Company with any other entity, other than a merger or
consolidation which would result in the voting securities of the Company outstanding immediately prior to such merger or consolidation continuing to represent (either by remaining outstanding or by being converted into voting securities of the
surviving entity) more than fifty-one percent (51%) of the combined voting power of the voting securities of the surviving entity outstanding immediately after such merger or consolidation and with the power to elect at least a majority of the
board of directors or other governing body of such surviving entity; 
 iv. Liquidation. The approval by the stockholders of the Company of
a complete liquidation of the Company or an agreement for the sale or disposition by the Company of all or substantially all of the Company’s assets; and 

v. Other Events. There occurs any other event of a nature that would be required to be reported in response to Item 6(e) of Schedule 14A
of Regulation 14A (or a response to any similar item on any similar schedule or form) promulgated under the Exchange Act (as defined below), whether or not the Company is then subject to such reporting requirement. 

For purposes of this Section 2(b), the following terms shall have the following meanings: 

(A) “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended from time to time. 

(B) “Person” shall have the meaning as set forth in Sections 13(d) and 14(d) of the Exchange Act; provided,
however, that Person shall exclude (i) the Company, (ii) any trustee or other 

  
 3 

 
fiduciary holding securities under an employee benefit plan of the Company, and (iii) any corporation owned, directly or indirectly, by the stockholders of the Company in substantially the
same proportions as their ownership of stock of the Company. 
 (C) “Beneficial Owner” shall have the meaning given
to such term in Rule 13d-3 under the Exchange Act; provided, however, that Beneficial Owner shall exclude any Person otherwise becoming a Beneficial Owner by reason of the stockholders of the Company approving a merger of the Company
with another entity. 
 (c) “Corporate Status” describes the status of a person who is or was a director, trustee, partner,
managing member, officer, employee, agent or fiduciary of the Company or of any other corporation, limited liability company, partnership or joint venture, trust or other enterprise which such person is or was serving at the request of the Company.

 (d) “Disinterested Director” shall mean a director of the Company who is not and was not a party to the Proceeding in respect
of which indemnification is sought by Indemnitee. 
 (e) “Enterprise” shall mean the Company and any other corporation, limited
liability company, partnership, joint venture, trust or other enterprise of which Indemnitee is or was serving at the request of the Company as a director, officer, trustee, partner, managing member, employee, agent or fiduciary. 

(f) “Expenses” shall include all reasonable attorneys’ fees, retainers, court costs, transcript costs, fees of experts and
other professionals, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees, fax transmission charges, secretarial services, any federal, state, local or foreign taxes imposed
on Indemnitee as a result of the actual or deemed receipt of any payments under this Agreement, ERISA excise taxes and penalties, and all other disbursements, obligations or expenses of the types customarily incurred in connection with, or as a
result of, prosecuting, defending, preparing to prosecute or defend, investigating, being or preparing to be a deponent or witness in, or otherwise participating in, a Proceeding. Expenses also shall include (i) Expenses incurred in connection
with any appeal resulting from any Proceeding, including without limitation the premium, security for, and other costs relating to any cost bond, supersedeas bond or other appeal bond or its equivalent, and (ii) expenses incurred in connection
with recovery under any directors’ and officers’ liability insurance policies maintained by the Company, regardless of whether the Indemnitee is ultimately determined to be entitled to such indemnification, advancement or Expenses or
insurance recovery, as the case may be, and (iii) for purposes of Section 14(d) only, Expenses incurred by or on behalf of Indemnitee in connection with the interpretation, enforcement or defense of Indemnitee’s rights under this
Agreement, by litigation or otherwise. The parties agree that for the purposes of any advancement of Expenses for which Indemnitee has made written demand to the Company in accordance with this Agreement, all

  
 4 

 
Expenses included in such demand that are certified by affidavit of Indemnitee’s counsel as being reasonable shall be presumed conclusively to be reasonable. Expenses, however, shall not
include amounts paid in settlement by Indemnitee or the amount of judgments or fines against Indemnitee. 
 (g) “Independent
Counsel” shall mean a law firm, or a member of a law firm, that is experienced in matters of corporation law and neither presently is, nor in the past five (5) years has been, retained to represent: (i) the Company or Indemnitee in
any matter material to either such party (other than with respect to matters concerning the Indemnitee under this Agreement, or of other indemnitees under similar indemnification agreements), or (ii) any other party to the Proceeding giving
rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term “Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of
interest in representing either the Company or Indemnitee in an action to determine Indemnitee’s rights under this Agreement. The Company agrees to pay the reasonable fees and expenses of the Independent Counsel referred to above and to fully
indemnify such counsel against any and all Expenses, claims, liabilities and damages arising out of or relating to this Agreement or its engagement pursuant hereto. 

(h) The term “Proceeding” shall include any threatened, pending or completed action, suit, claim, counterclaim, cross claim,
arbitration, mediation, alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or any other actual, threatened or completed proceeding, whether brought in the right of the Company or otherwise and whether of a civil,
criminal, administrative, regulatory, legislative or investigative (formal or informal) nature, including any appeal therefrom, in which Indemnitee was, is or will be involved as a party, potential party, non-party witness or otherwise by reason of
the fact that Indemnitee is or was a director or officer of the Company, by reason of any action taken by him or her (or a failure to take action by him or her) or of any action (or failure to act) on his or her part while acting pursuant to his or
her Corporate Status, in each case whether or not serving in such capacity at the time any liability or Expense is incurred for which indemnification, reimbursement or advancement of Expenses can be provided under this Agreement. If the Indemnitee
believes in good faith that a given situation may lead to or culminate in the institution of a Proceeding, this shall be considered a Proceeding under this paragraph. 

(i) Reference to “other enterprise” shall include employee benefit plans; references to “fines” shall include any excise
tax assessed with respect to any employee benefit plan; references to “serving at the request of the Company” shall include any service as a director, officer, employee or agent of the Company which imposes duties on, or involves services
by, such director, officer, employee or agent with respect to an employee benefit plan, its participants or beneficiaries; and a person who acted in good faith and in a manner he or she reasonably believed to be in the best interests of the
participants and beneficiaries of an employee benefit plan shall be deemed to have acted in manner “not opposed to the best interests of the Company” as referred to in this Agreement. 

  
 5 

 Section 3. Indemnity in Third-Party Proceedings. The Company shall indemnify
Indemnitee in accordance with the provisions of this Section 3 if Indemnitee is, or is threatened to be made, a party to or a participant in any Proceeding, other than a Proceeding by or in the right of the Company to procure a judgment in its
favor. Pursuant to this Section 3, Indemnitee shall be indemnified to the fullest extent permitted by applicable law against all Expenses, judgments, fines and amounts paid in settlement (including all interest, assessments and other charges
paid or payable in connection with or in respect of such Expenses, judgments, fines and amounts paid in settlement) actually and reasonably incurred by Indemnitee or on his or her behalf in connection with such Proceeding or any claim, issue or
matter therein, if Indemnitee acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the Company and, in the case of a criminal Proceeding had no reasonable cause to believe that his or her
conduct was unlawful. The parties hereto intend that this Agreement shall provide to the fullest extent permitted by law for indemnification in excess of that expressly permitted by statute, including, without limitation, any indemnification
provided by the Certificate of Incorporation, the Bylaws, vote of its stockholders or disinterested directors or applicable law. 

Section 4. Indemnity in Proceedings by or in the Right of the Company. The Company shall indemnify Indemnitee in accordance with
the provisions of this Section 4 if Indemnitee is, or is threatened to be made, a party to or a participant in any Proceeding by or in the right of the Company to procure a judgment in its favor. Pursuant to this Section 4, Indemnitee
shall be indemnified to the fullest extent permitted by applicable law against all Expenses actually and reasonably incurred by him or her or on his or her behalf in connection with such Proceeding or any claim, issue or matter therein, if
Indemnitee acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the best interests of the Company. No indemnification for Expenses shall be made under this Section 4 in respect of any claim, issue or
matter as to which Indemnitee shall have been finally adjudged by a court to be liable to the Company, unless and only to the extent that the Delaware Court of Chancery or any court in which the Proceeding was brought shall determine upon
application that, despite the adjudication of liability but in view of all the circumstances of the case, Indemnitee is fairly and reasonably entitled to indemnification. 

Section 5. Indemnification for Expenses of a Party Who is Wholly or Partly Successful. Notwithstanding any other provisions of
this Agreement, to the fullest extent permitted by applicable law and to the extent that Indemnitee is a party to (or a participant in) and is successful, on the merits or otherwise, in any Proceeding or in defense of any claim, issue or matter
therein, in whole or in part, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or her in connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful, on the
merits or otherwise, as to one or more but less than all claims, issues or matters in such Proceeding, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or her or on his or her behalf in connection
with or related to each successfully resolved claim, issue or matter to the fullest extent permitted by law. For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with
or without prejudice, shall be deemed to be a successful result as to such claim, issue or matter. 

  
 6 

 Section 6. Indemnification For Expenses of a Witness. Notwithstanding any other
provision of this Agreement, to the fullest extent permitted by applicable law and to the extent that Indemnitee is, by reason of his or her Corporate Status, a witness or otherwise asked to participate in any aspect of a Proceeding to which
Indemnitee is not a party, he or she shall be indemnified against all Expenses actually and reasonably incurred by him or her on his or her behalf in connection therewith. 

Section 7. Partial Indemnification. If Indemnitee is entitled under any provision of this Agreement to indemnification by the
Company for some or a portion of Expenses, but not, however, for the total amount thereof, the Company shall nevertheless indemnify Indemnitee for the portion thereof to which Indemnitee is entitled. 

Section 8. Additional Indemnification. 

(a) Notwithstanding any limitation in Sections 3, 4 or 5, the Company shall indemnify Indemnitee to the fullest extent permitted by applicable
law if Indemnitee is a party to or threatened to be made a party to or a participant in any Proceeding (including a Proceeding by or in the right of the Company to procure a judgment in its favor) against all Expenses, judgments, fines and amounts
paid in settlement (including all interest, assessments and other charges paid or payable in connection with or in respect of such Expenses, judgments, fines and amounts paid in settlement) actually and reasonably incurred by or on behalf of
Indemnitee in connection with the Proceeding. 
 (b) For purposes of Section 8(a), the meaning of the phrase “to the fullest
extent permitted by applicable law” shall include, but not be limited to: 
 i. to the fullest extent permitted by the provision of the
DGCL that authorizes or contemplates additional indemnification by agreement, or the corresponding provision of any amendment to or replacement of the DGCL, and 

ii. to the fullest extent authorized or permitted by any amendments to or replacements of the DGCL adopted after the date of this Agreement
that increase the extent to which a corporation may indemnify its officers and directors. 
 Section 9. Exclusions.
Notwithstanding any provision in this Agreement, the Company shall not be obligated under this Agreement to make any indemnification payment in connection with any claim made against Indemnitee: 

(a) for which payment has actually been made to or on behalf of Indemnitee under any insurance policy or other indemnity provision, except with
respect to any excess beyond the amount paid under any insurance policy or other indemnity provision; or 

  
 7 

 (b) for (i) an accounting of profits made from the purchase and sale (or sale and purchase)
by Indemnitee of securities of the Company within the meaning of Section 16(b) of the Exchange Act (as defined in Section 2(b) hereof) or similar provisions of state statutory law or common law, or (ii) any reimbursement of the
Company by the Indemnitee of any bonus or other incentive-based or equity-based compensation or of any profits realized by the Indemnitee from the sale of securities of the Company, as required in each case under the Exchange Act (including any such
reimbursements that arise from an accounting restatement of the Company pursuant to Section 304 of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”), or the payment to the Company of profits arising from the purchase and sale
by Indemnitee of securities in violation of Section 306 of the Sarbanes-Oxley Act); or 
 (c) except as provided in Section 14(d)
of this Agreement, in connection with any Proceeding (or any part of any Proceeding) initiated by Indemnitee, including any Proceeding (or any part of any Proceeding) initiated by Indemnitee against the Company or its directors, officers, employees
or other indemnitees, unless (i) the Board authorized the Proceeding (or any part of any Proceeding) prior to its initiation, (ii) such payment arises in connection with any mandatory counterclaim or cross-claim or affirmative defense
brought or raised by Indemnitee in any Proceeding (or any part of any Proceeding), or (iii) the Company provides the indemnification, in its sole discretion, pursuant to the powers vested in the Company under applicable law. 

Section 10. Advances of Expenses. Notwithstanding any provision of this Agreement to the contrary (other than Section 14(d)),
the Company shall advance, to the extent not prohibited by law, the Expenses incurred by or on behalf of Indemnitee in connection with any Proceeding (or any part of any Proceeding) not initiated by Indemnitee, and such advancement shall be made
within thirty (30) days after the receipt by the Company of a statement or statements requesting such advances from time to time (which shall include invoices received by the Indemnitee in connection with such Expenses but, in the case of
invoices in connection with legal services, any references to legal work performed or to expenditures made that would cause Indemnitee to waive any privilege accorded by applicable law shall not be so included), whether prior to or after final
disposition of any Proceeding. Advances shall be unsecured and interest free. Advances shall be made without regard to Indemnitee’s ability to repay the Expenses and without regard to Indemnitee’s ultimate entitlement to indemnification
under the other provisions of this Agreement. In accordance with Section 14(d), advances shall include any and all reasonable Expenses incurred pursuing an action to enforce this right of advancement, including Expenses incurred preparing and
forwarding statements to the Company to support the advances claimed. The Indemnitee shall qualify for advances upon the execution and delivery to the Company of this Agreement, which shall constitute an undertaking providing that the Indemnitee
undertakes to repay the amounts advanced (without interest) to the extent that it is ultimately determined that Indemnitee is not entitled to be indemnified by the Company. No other form of undertaking shall be required other than the execution of
this Agreement. This Section 10 shall not apply to any claim made by Indemnitee for which indemnity is excluded pursuant to Section 9. 

  
 8 

 Section 11. Procedure for Notification and Defense of Claim. 

(a) Indemnitee shall notify the Company in writing of any matter with respect to which Indemnitee intends to seek indemnification or
advancement of Expenses hereunder as soon as reasonably practicable following the receipt by Indemnitee of written notice thereof or Indemnitee’s becoming aware thereof. The written notification to the Company shall include a description of the
nature of the Proceeding and the facts underlying the Proceeding, in each case to the extent known to Indemnitee. To obtain indemnification under this Agreement, Indemnitee shall submit to the Company a written request, including therein or
therewith such documentation and information as is reasonably available to Indemnitee and is reasonably necessary to determine whether and to what extent Indemnitee is entitled to indemnification following the final disposition of such Proceeding.
The failure by Indemnitee to notify the Company hereunder will not relieve the Company from any liability which it may have to Indemnitee hereunder or otherwise than under this Agreement, and any delay in so notifying the Company shall not
constitute a waiver by Indemnitee of any rights under this Agreement, except to the extent (solely with respect to the indemnity hereunder) that such failure or delay materially prejudices the Company. The Secretary of the Company shall, promptly
upon receipt of such a request for indemnification, advise the Board in writing that Indemnitee has requested indemnification. 
 (b) The
Company will be entitled to participate in the Proceeding at its own expense. 
 (c) The Company shall not settle any Proceeding (in whole
or in part) if such settlement would impose any Expense, judgment, liability, fine, penalty or limitation on Indemnitee which Indemnitee is not entitled to be indemnified hereunder without the Indemnitee’s prior written consent. 

Section 12. Procedure Upon Application for Indemnification. 

(a) Upon written request by Indemnitee for indemnification pursuant to Section 11(a), a determination, if required by applicable law,
with respect to Indemnitee’s entitlement thereto shall be made in the specific case: (i) if a Change in Control shall have occurred, by Independent Counsel in a written opinion to the Board, a copy of which shall be delivered to
Indemnitee; or (ii) if a Change in Control shall not have occurred, (A) by a majority vote of the Disinterested Directors, even though less than a quorum of the Board, (B) by a committee of Disinterested Directors designated by a
majority vote of the Disinterested Directors, even though less than a quorum of the Board, (C) if there are no such Disinterested Directors or, if such Disinterested Directors so direct, by Independent Counsel in a written opinion to the Board,
a copy of which shall be delivered to Indemnitee, or (D) if so directed by the Board, by the stockholders of the Company; and, if it is so determined that Indemnitee is entitled to indemnification, payment to Indemnitee shall be made within ten
(10) days after such determination. Indemnitee shall cooperate with the person, persons or entity making such determination with respect to Indemnitee’s entitlement to indemnification, including providing to such person, persons or entity
upon reasonable advance request any documentation or 

  
 9 

 
information which is not privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee and reasonably necessary to such determination. Any costs or Expenses
(including attorneys’ fees and disbursements) incurred by or on behalf of Indemnitee in so cooperating with the person, persons or entity making such determination shall be borne by the Company (irrespective of the determination as to
Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold Indemnitee harmless therefrom. The Company promptly will advise Indemnitee in writing with respect to any determination that Indemnitee is or is
not entitled to indemnification, including a description of any reason or basis for which indemnification has been denied. 
 (b) In the
event the determination of entitlement to indemnification is to be made by Independent Counsel pursuant to Section 12(a) hereof, the Independent Counsel shall be selected as provided in this Section 12(b). If a Change in Control shall not
have occurred, the Independent Counsel shall be selected by the Board, and the Company shall give written notice to Indemnitee advising him or her of the identity of the Independent Counsel so selected. If a Change in Control shall have occurred,
the Independent Counsel shall be selected by Indemnitee (unless Indemnitee shall request that such selection be made by the Board, in which event the preceding sentence shall apply), and Indemnitee shall give written notice to the Company advising
it of the identity of the Independent Counsel so selected. In either event, Indemnitee or the Company, as the case may be, may, within ten (10) days after such written notice of selection shall have been given, deliver to the Company or to
Indemnitee, as the case may be, a written objection to such selection; provided, however, that such objection may be asserted only on the ground that the Independent Counsel so selected does not meet the requirements of
“Independent Counsel” as defined in Section 2 of this Agreement, and the objection shall set forth with particularity the factual basis of such assertion. Absent a proper and timely objection, the person so selected shall act as
Independent Counsel. If such written objection is so made and substantiated, the Independent Counsel so selected may not serve as Independent Counsel unless and until such objection is withdrawn or the Delaware Court has determined that such
objection is without merit. If, within twenty (20) days after the later of submission by Indemnitee of a written request for indemnification pursuant to Section 11(a) hereof and the final disposition of the Proceeding, no Independent
Counsel shall have been selected and not objected to, either the Company or Indemnitee may petition the Delaware Court for resolution of any objection which shall have been made by the Company or Indemnitee to the other’s selection of
Independent Counsel and/or for the appointment as Independent Counsel of a person selected by such court or by such other person as such court shall designate, and the person with respect to whom all objections are so resolved or the person so
appointed shall act as Independent Counsel under Section 12(a) hereof. Upon the due commencement of any judicial proceeding or arbitration pursuant to Section 14(a) of this Agreement, Independent Counsel shall be discharged and relieved of
any further responsibility in such capacity (subject to the applicable standards of professional conduct then prevailing). 
 (c) If the
Company disputes a portion of the amounts for which indemnification is requested, the undisputed portion shall be paid and only the disputed portion withheld pending resolution of any such dispute. 

  
 10 

 Section 13. Presumptions and Effect of Certain Proceedings. 

(a) In making a determination with respect to entitlement to indemnification hereunder, the person or persons or entity making such
determination shall, to the fullest extent not prohibited by law, presume that Indemnitee is entitled to indemnification under this Agreement if Indemnitee has submitted a request for indemnification in accordance with Section 11(a) of this
Agreement, and the Company shall, to the fullest extent not prohibited by law, have the burden of proof to overcome that presumption in connection with the making by any person, persons or entity of any determination contrary to that presumption.
Neither the failure of the Company (including by its directors or Independent Counsel) to have made a determination prior to the commencement of any action pursuant to this Agreement that indemnification is proper in the circumstances because
Indemnitee has met the applicable standard of conduct, nor an actual determination by the Company (including by its directors or Independent Counsel) that Indemnitee has not met such applicable standard of conduct, shall be a defense to the action
or create a presumption that Indemnitee has not met the applicable standard of conduct. 
 (b) Subject to Section 14(e), if the person,
persons or entity empowered or selected under Section 12 of this Agreement to determine whether Indemnitee is entitled to indemnification shall not have made a determination within sixty (60) days after receipt by the Company of the
request therefor, the requisite determination of entitlement to indemnification shall, to the fullest extent not prohibited by law, be deemed to have been made and Indemnitee shall be entitled to such indemnification, absent (i) a misstatement
by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such indemnification under
applicable law; provided, however, that such sixty (60)-day period may be extended for a reasonable time, not to exceed an additional thirty (30) days, if the person, persons or entity making the determination with respect to
entitlement to indemnification in good faith requires such additional time for the obtaining or evaluating of documentation and/or information relating thereto; and provided, further, that the foregoing provisions of this
Section 13(b) shall not apply (i) if the determination of entitlement to indemnification is to be made by the stockholders pursuant to Section 12(a) of this Agreement and if (A) within fifteen (15) days after receipt by the
Company of the request for such determination the Board has resolved to submit such determination to the stockholders for their consideration at an annual meeting thereof to be held within seventy-five (75) days after such receipt and such
determination is made thereat, or (B) a special meeting of stockholders is called within fifteen (15) days after such receipt for the purpose of making such determination, such meeting is held for such purpose within sixty (60) days
after having been so called and such determination is made thereat, or (ii) if the determination of entitlement to indemnification is to be made by Independent Counsel pursuant to Section 12(a) of this Agreement. 

(c) The termination of any Proceeding or of any claim, issue or matter therein, by judgment, order, settlement or conviction, or upon a plea
of nolo contendere or its equivalent, shall not (except as otherwise expressly provided in this Agreement) of itself adversely affect the right of Indemnitee to indemnification or create a presumption that Indemnitee did not act in

  
 11 

 
good faith and in a manner which he or she reasonably believed to be in or not opposed to the best interests of the Company or, with respect to any criminal Proceeding, that Indemnitee had
reasonable cause to believe that his or her conduct was unlawful. 
 (d) For purposes of any determination of good faith, Indemnitee shall
be deemed to have acted in good faith if Indemnitee’s action is based on the records or books of account of the Enterprise, including financial statements, or on information supplied to Indemnitee by the directors or officers of the Enterprise
in the course of their duties, or on the advice of legal counsel for the Enterprise or on information or records given or reports made to the Enterprise by an independent certified public accountant or by an appraiser or other expert selected with
reasonable care by the Enterprise. The provisions of this Section 13(d) shall not be deemed to be exclusive or to limit in any way the other circumstances in which Indemnitee may be deemed to have met the applicable standard of conduct set
forth in this Agreement. Whether or not the foregoing provisions of this Section 13(d) are satisfied, it shall in any event be presumed that Indemnitee has at all times acted in good faith and in a manner reasonably believed to be in or not
opposed to the best interests of the Company. 
 (e) The knowledge and/or actions, or failure to act, of any director, officer, trustee,
partner, managing member, fiduciary, agent or employee of the Enterprise shall not be imputed to Indemnitee for purposes of determining the right to indemnification under this Agreement. 

Section 14. Remedies of Indemnitee. 

(a) Subject to Section 14(e), in the event that (i) a determination is made pursuant to Section 12 of this Agreement that
Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 10 of this Agreement, (iii) no determination of entitlement to indemnification shall have been
made pursuant to Section 12(a) of this Agreement within ninety (90) days after receipt by the Company of the request for indemnification, (iv) payment of indemnification is not made pursuant to Section 5, 6 or 7 or the last
sentence of Section 12(a) of this Agreement within ten (10) days after receipt by the Company of a written request therefor, (v) payment of indemnification pursuant to Section 3, 4 or 8 of this Agreement is not made within ten
(10) days after a determination has been made that Indemnitee is entitled to indemnification, or (vi) in the event that the Company or any other person takes or threatens to take any action to declare this Agreement void or unenforceable,
or institutes any litigation or other action or Proceeding designed to deny, or to recover from, the Indemnitee the benefits provided or intended to be provided to the Indemnitee hereunder, Indemnitee shall be entitled to an adjudication by a court
of his or her entitlement to such indemnification or advancement of Expenses. Alternatively, Indemnitee, at his or her option, may seek an award in arbitration to be conducted by a single arbitrator pursuant to the Commercial Arbitration Rules of
the American Arbitration Association. Indemnitee shall commence such proceeding seeking an adjudication or an award in arbitration within one hundred eighty(180) days following the date on which Indemnitee first has the right to commence such
proceeding pursuant to this Section 14(a); provided, however, that the 

  
 12 

 
foregoing clause shall not apply in respect of a proceeding brought by Indemnitee to enforce his or her rights under Section 5 of this Agreement. The Company shall not oppose
Indemnitee’s right to seek any such adjudication or award in arbitration. 
 (b) In the event that a determination shall have been made
pursuant to Section 12(a) of this Agreement that Indemnitee is not entitled to indemnification, any judicial proceeding or arbitration commenced pursuant to this Section 14 shall be conducted in all respects as a de novo trial, or
arbitration, on the merits and Indemnitee shall not be prejudiced by reason of that adverse determination. In any judicial proceeding or arbitration commenced pursuant to this Section 14 the Company shall have the burden of proving Indemnitee
is not entitled to indemnification or advancement of Expenses, as the case may be. 
 (c) If a determination shall have been made pursuant
to Section 12(a) of this Agreement that Indemnitee is entitled to indemnification, the Company shall be bound by such determination in any judicial proceeding or arbitration commenced pursuant to this Section 14, absent (i) a
misstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such
indemnification under applicable law. 
 (d) The Company shall, to the fullest extent not prohibited by law, be precluded from asserting in
any judicial proceeding or arbitration commenced pursuant to this Section 14 that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court or before any such arbitrator that
the Company is bound by all the provisions of this Agreement. It is the intent of the Company that, to the fullest extent permitted by law, the Indemnitee not be required to incur legal fees or other Expenses associated with the interpretation,
enforcement or defense of Indemnitee’s rights under this Agreement by litigation or otherwise because the cost and expense thereof would substantially detract from the benefits intended to be extended to the Indemnitee hereunder. The Company
shall, to the fullest extent permitted by law, indemnify Indemnitee against any and all Expenses and, if requested by Indemnitee, shall (within ten (10) days after receipt by the Company of a written request therefor) advance, to the extent not
prohibited by law, such Expenses to Indemnitee, which are incurred by or on behalf of Indemnitee in connection with any action brought by Indemnitee for indemnification or advancement of Expenses from the Company under this Agreement or under any
directors’ and officers’ liability insurance policies maintained by the Company if, in the case of indemnification, Indemnitee is wholly successful on the underlying claims; if Indemnitee is not wholly successful on the underlying claims,
then such indemnification shall be only to the extent Indemnitee is successful on such underlying claims or otherwise as permitted by law, whichever is greater. 

(e) Notwithstanding anything in this Agreement to the contrary, no determination as to entitlement of Indemnitee to indemnification under this
Agreement shall be required to be made prior to the final disposition of the Proceeding. 

  
 13 

 Section 15. Non-exclusivity; Survival of Rights; Insurance; Subrogation. 

(a) The rights of indemnification and to receive advancement of Expenses as provided by this Agreement (i) shall not be deemed exclusive
of any other rights to which Indemnitee may at any time be entitled under applicable law, the Certificate of Incorporation, the Bylaws, any agreement, a vote of stockholders or a resolution of directors or otherwise, and (ii) shall be
interpreted independently of, and without reference to, any other such rights to which Indemnitee may at any time be entitled. No amendment, alteration or repeal of this Agreement or of any provision hereof shall limit or restrict any right of
Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his or her Corporate Status prior to such amendment, alteration or repeal. To the extent that a change in Delaware law, whether by statute or judicial
decision, permits greater indemnification or advancement of Expenses than would be afforded currently under the Bylaws, the Certificate of Incorporation and this Agreement, it is the intent of the parties hereto that Indemnitee shall enjoy by this
Agreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right and remedy shall be cumulative and in addition to every other right and
remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not prevent the concurrent assertion or employment of any other right or remedy.

 (b) To the extent that the Company maintains an insurance policy or policies providing liability insurance for directors, officers,
employees or agents of the Enterprise, Indemnitee shall be covered by such policy or policies in accordance with its or their terms to the maximum extent of the coverage available for any such director, officer, employee or agent under such policy
or policies. If, at the time of the receipt of a notice of a claim pursuant to the terms hereof, the Company has director and officer liability insurance in effect, the Company shall give prompt notice of such claim or of the commencement of a
Proceeding, as the case may be, to the insurers in accordance with the procedures set forth in the respective policies. The Company shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee,
all amounts payable as a result of such Proceeding in accordance with the terms of such policies. 
 (c) In the event of any payment under
this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all papers required and take all action necessary to secure such rights, including execution of such
documents as are necessary to enable the Company to bring suit to enforce such rights. 
 (d) The Company shall not be liable under this
Agreement to make any payment of amounts otherwise indemnifiable (or for which advancement is provided hereunder) hereunder if and to the extent that Indemnitee has otherwise actually received such payment under any insurance policy, contract,
agreement or otherwise. 
 (e) The Company’s obligation to indemnify or advance Expenses hereunder to Indemnitee who is or was serving
at the request of the Company as a director, officer, trustee, 

  
 14 

 
partner, managing member, fiduciary, employee or agent of any other corporation, limited liability company, partnership, joint venture, trust, employee benefit plan or other enterprise shall be
reduced by any amount Indemnitee has actually received as indemnification or advancement of Expenses from such other corporation, limited liability company, partnership, joint venture, trust or other enterprise. 

Section 16. Duration of Agreement. This Agreement shall continue until and terminate upon the later of: (a) ten
(10) years after the date that Indemnitee shall have ceased to serve as a director, officer, employee or agent of the Company, as applicable, or, at the request of the Company, as a director, officer, employee, agent or fiduciary of another
corporation, partnership, joint venture, trust or other enterprise, as applicable, or (b) one (1) year after the final termination of any Proceeding then pending in respect of which Indemnitee is granted rights of indemnification or
advancement of Expenses hereunder and of any proceeding commenced (including any appeal thereof) by Indemnitee pursuant to Section 14 of this Agreement relating thereto. The indemnification and advancement of expenses rights provided by or
granted pursuant to this Agreement shall be binding upon and be enforceable by the parties hereto and their respective successors and assigns (including any direct or indirect successor by purchase, merger, consolidation or otherwise to all or
substantially all of the business or assets of the Company), shall continue as to an Indemnitee who has ceased to be a director, officer, employee or agent of the Company or of any other Enterprise, and shall inure to the benefit of Indemnitee and
his or her spouse, assigns, heirs, devisees, executors and administrators and other legal representatives. The Company shall require and shall cause any successor (whether direct or indirect by purchase, merger, consolidation or otherwise) to all or
substantially all of the business or assets of the Company to, by written agreement, expressly assume and agree to perform this Agreement in the same manner and to the same extent that the Company would be required to perform if no such succession
had taken place. 
 Section 17. Severability. If any provision or provisions of this Agreement shall be held to be invalid,
illegal or unenforceable for any reason whatsoever: (a) the validity, legality and enforceability of the remaining provisions of this Agreement (including without limitation, each portion of any Section of this Agreement containing any such
provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall not in any way be affected or impaired thereby and shall remain enforceable to the fullest extent permitted by law; (b) such
provision or provisions shall be deemed reformed to the extent necessary to conform to applicable law and to give the maximum effect to the intent of the parties hereto; and (c) to the fullest extent possible, the provisions of this Agreement
(including, without limitation, each portion of any Section of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall be construed so as to give effect
to the intent manifested thereby. 
 Section 18. Enforcement. 

(a) The Company expressly confirms and agrees that it has entered into this Agreement and assumed the obligations imposed on it hereby in
order to induce Indemnitee to serve as a director or officer of the Company, and the Company acknowledges that Indemnitee is relying upon this Agreement in serving as a director or officer of the Company. 

  
 15 

 (b) This Agreement constitutes the entire agreement between the parties hereto with respect to
the subject matter hereof and supersedes all prior agreements and understandings, oral, written and implied, between the parties hereto with respect to the subject matter hereof; provided, however, that this Agreement is a supplement
to and in furtherance of the Certificate of Incorporation, the Bylaws, any directors’ and officers’ insurance maintained by the Company and applicable law, and shall not be deemed a substitute therefor, nor to diminish or abrogate any
rights of Indemnitee thereunder and provided further, that the provisions of this Agreement shall apply retroactively as of the date such Indemnitee began service as a director, officer, employee or agent of the Company, as applicable, or, at
the request of the Company, as a director, officer, employee, agent or fiduciary of another corporation, partnership, joint venture, trust or other enterprise, as applicable. 

Section 19. Modification and Waiver. No supplement, modification or amendment of this Agreement shall be binding unless executed
in writing by the parties hereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions of this Agreement nor shall any waiver constitute a continuing waiver. 

Section 20. Notice by Indemnitee. Indemnitee agrees promptly to notify the Company in writing upon being served with any summons,
citation, subpoena, complaint, indictment, information or other document relating to any Proceeding or matter which may be subject to indemnification or advancement of Expenses covered hereunder. The failure of Indemnitee to so notify the Company
shall not relieve the Company of any obligation which it may have to the Indemnitee under this Agreement or otherwise. 
 Section 21.
Notices. All notices, requests, demands and other communications under this Agreement shall be in writing and shall be deemed to have been duly given if (a) delivered by hand and receipted for by the party to whom said notice or other
communication shall have been directed, (b) mailed by certified or registered mail with postage prepaid, on the third business day after the date on which it is so mailed, (c) mailed by reputable overnight courier and receipted for by the
party to whom said notice or other communication shall have been directed, or (d) sent by facsimile transmission, with receipt of oral confirmation that such transmission has been received: 

(a) If to Indemnitee, at the address indicated on the signature page of this Agreement, or such other address as Indemnitee shall provide to
the Company. 
 (b) If to the Company to: 

Chief Financial Officer 

Avalanche Biotechnologies, Inc. 

1035 O’Brien Drive, Suite A 

Menlo Park, CA 94025 
 (650)
272-6269 

  
 16 

 or to any other address as may have been furnished to Indemnitee by the Company. 

Section 22. Contribution. To the fullest extent permissible under applicable law, if the indemnification provided for in this
Agreement is unavailable to Indemnitee for any reason whatsoever, the Company, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by or on behalf of Indemnitee, whether for judgments, fines, penalties, excise taxes, amounts
paid or to be paid in settlement and/or for Expenses, in connection with any claim relating to an indemnifiable event under this Agreement, in such proportion as is deemed fair and reasonable in light of all of the circumstances of such Proceeding
in order to reflect (i) the relative benefits received by the Company and Indemnitee as a result of the event(s) and/or transaction(s) giving cause to such Proceeding; and/or (ii) the relative fault of the Company (and its directors,
officers, employees and agents) and Indemnitee in connection with such event(s) and/or transaction(s). 
 Section 23. Applicable Law
and Consent to Jurisdiction. This Agreement and the legal relations among the parties shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware, without regard to its conflict of laws rules. Except
with respect to any arbitration commenced by Indemnitee pursuant to Section 14(a) of this Agreement, the Company and Indemnitee hereby irrevocably and unconditionally (i) agree that any action or proceeding arising out of or in connection
with this Agreement shall be brought only in the Chancery Court of the State of Delaware (the “Delaware Court”), and not in any other state or federal court in the United States of America or any court in any other country,
(ii) consent to submit to the exclusive jurisdiction of the Delaware Court for purposes of any action or proceeding arising out of or in connection with this Agreement, (iii) appoint, to the extent such party is not otherwise subject to
service of process in the State of Delaware, irrevocably The Corporation Trust Company c/o Corporation Trust Center, 1209 Orange Street, in the City of Wilmington, County of New Castle, 19801 as its agent in the State of Delaware for acceptance of
legal process in connection with any such action or proceeding against such party with the same legal force and validity as if served upon such party personally within the State of Delaware, (iv) waive any objection to the laying of venue of
any such action or proceeding in the Delaware Court, and (v) waive, and agree not to plead or to make, any claim that any such action or proceeding brought in the Delaware Court has been brought in an improper or inconvenient forum. 

Section 24. Identical Counterparts. This Agreement may be executed in one or more counterparts, each of which shall for all
purposes be deemed to be an original but all of which together shall constitute one and the same Agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of this
Agreement. 
 Section 25. Miscellaneous. The headings of this Agreement are inserted for convenience only and shall not be
deemed to constitute part of this Agreement or to affect the construction thereof. 

  
 17 

 IN WITNESS WHEREOF, the parties have caused this Agreement to be signed as of the day and year
first above written. 
  

									
	AVALANCHE BIOTECHNOLOGIES, INC.	 		 	INDEMNITEE
				
	By:	 	  
	 		 	  

		 	Name:	 		 	Name:	  	
		 	Title:	 		 	Address:	  	

  
 18

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