Document:

EXHIBIT 10.56

                             SUBSCRIPTION AGREEMENT

                                                August 20, 2003
NexGen Bacterium, Inc.
Arango-Orillac Building, 2nd  Floor
East 54th Street
Panama City, Panama

Gentlemen:

     This  letter  will  constitute  the subscription agreement between New York
Health  Care, Inc. ("NYHC" or the "Company"), a New York corporation, and NexGen
Bacterium,  Inc.,  a Panama corporation, ("you" or the "Investor") regarding its
acquisition  of  shares  of  the  $.01  par  value  common  stock  of  NYHC.

     1.     Subscription.  The  Investor  agrees  to  accept  from NYHC and NYHC
            ------------
agrees  to issue to the Investor 1,000,000 shares of the unissued $.01 par value
common  stock  (the  "Shares") of NYHC as part of the purchase price for certain
assets  being  sold  by  the  Investor  to  The  Bio  Balance  Corp.  ("Bio"), a
wholly-owned  subsidiary  of NYHC, pursuant to an Asset Purchase Agreement among
the  Investor,  Bio  and NYHC (the "Asset Agreement"), and a Registration Rights
Agreement  among  the  Investor  and NYHC (the "Registration Rights Agreement"),
both  approved  August  20,  2003.

     2.     Representations,  Warranties  and  Covenants  of  Subscriber.  The
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Investor  hereby  acknowledges,  represents,  warrants,  covenants and agrees as
follows:

          (a)     the Investor has been furnished with full access to the books,
records  and  reports  of  the  Company, including but not limited to all of the
Company's  SEC  Form  10-K,  10-Q

<PAGE>
and  8-K  reports and all documents filed by the Company or any insider with the
SEC,  and  any  documents  which  may  have  been  made  available  upon request
(collectively  referred  to  as  "additional  materials");

          (b)     the  Investor  has been given the opportunity to ask questions
of  and  receive  answers from the Company's officers, directors and independent
accountants  concerning  matters  pertaining to an investment in the Company and
has  been  given  the opportunity to obtain such information necessary to verify
the  accuracy  of  information  that  was  otherwise provided in order for it to
evaluate  the  merits  and  risks  of an acquisition of Shares to the extent the
Company possesses such information or can acquire it without unreasonable effort
or  expense,  and  has  not  been  furnished  any  offering literature except as
mentioned  herein;

          (c)     the  Investor  has  not  been  furnished  with  any  oral
representation  in  connection  with  the  Shares;

          (d)     the Investor has determined that the Shares it is accepting as
payment for the Assets being in the Asset Agreement are a suitable investment in
view  of  its  presently  anticipated financial needs and that it and all of its
equity  owners  could  bear  a  loss  of the investment at this time and for the
foreseeable  future;

          (e)     with the exception of its reliance on any information provided
by  the  Company  as  part  of  a  due  diligence examination of the Company for
purposes of reaching its decision as to whether or not to invest in the Company,
the  Investor is not relying on the Company, its officers, directors, employees,
agents,  investment  bankers  or  attorneys,  with respect to individual tax and
other  legal  or  economic  considerations  involved  in  this  investment.  The
Investor  has  relied on its knowledge and experience, and that of its legal and
economic  advisors,  with  regard  to  the  tax  and  other  legal  or  economic
considerations  involved  in  this  transaction.  The  Investor  is  capable  of
evaluating  the  merits  and  risks  of  this  investment;

          (f)     except as provided in the Asset Agreement and the Registration
Rights  Agreement,  the  Investor will not sell or otherwise transfer the Shares
without registration under the Securities Act of 1933 (the "Securities Act") and
appropriate  state  securities  ("Blue  Sky")  laws  or  the  availability  of
appropriate  exemptions  therefrom and fully understands and agrees that he must
bear  the  economic  risks  of  its  purchase  for  an indefinite period of time
because,  among  other  reasons,  the  Shares have not been registered under the
Securities Act or under the Blue Sky laws of any state and, therefore, cannot be
resold, pledged, assigned, hypothecated or otherwise disposed of unless they are
subsequently  registered  under the Securities Act and under the applicable Blue
Sky  laws  or  pursuant  to  available  exemptions  from  such  registration;

          (g)     the  Investor  is  a  citizen  and  resident  of  Panama;

          (h)     the Investor is an "accredited investor" as defined in Section
2(15) of the Securities Act of 1933, as amended, and Rule 501 promulgated by the
United  States  Securities  and  Exchange  Commission  thereunder;

<PAGE>
          (i)     except  as  provided  in  the  Asset Agreement, the Shares the
Investor  is  accepting  will  be  solely  for  the  account of the Investor for
investment  purposes  only  and  are  not  being purchased for any distribution,
subdivision  or  fractionalization  thereof;  the  Investor  has  no  contract,
undertaking agreement or arrangement with any person to sell, transfer or pledge
any  Shares  to such person or anyone else and has no present plan to enter into
any  such  contract,  undertaking,  agreement  or  arrangement;

          (j)     the  Investor has furnished the Company with information about
the  Investor  and such information is correct and complete as of this date.  If
there  should  be  any  material  change  in such information, the Investor will
immediately  furnish  such  revised or corrected information to the Company; and

          (k)     it  has  made  the  foregoing  representations,  warranties,
covenants and agreements knowing that they shall survive its purchase of Shares.

     3.     Representations,  Warranties  and  Covenants  of  the  Company.  The
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Company  hereby  acknowledges,  represents,  warrants,  covenants  and agrees as
follows:

          (a)     The  Company is a corporation duly organized, validly existing
and  in  good  standing  under  the  laws  of  the State of New York and has all
requisite power and authority to own, lease and operate its properties, carry on
its  business as now being conducted, enter into this Subscription Agreement and
consummate  the transactions contemplated hereby.  The execution and delivery by
the  Company  of  this  Agreement  and  the  consummation  of  the  transactions
contemplated  hereby  have  been  duly  and  validly authorized by all necessary
corporate action on the part of the Company and this Agreement is a legal, valid
and  binding  obligation  of  the  Company  enforceable  against  the Company in
accordance with its terms.  Neither the execution and delivery by the Company of
this Agreement nor the consummation of the transactions contemplated hereby will
conflict  with  or  result  in  a  breach of any provision of its Certificate of
Incorporation or By-Laws or result in a material default under any of the terms,
conditions  or  provisions  of  any  note,  bond,  mortgage, indenture, license,
agreement,  judgment,  court  order,  restraint,  lien  or  other  instrument or
obligation to which the Company is a party or by which the Company or its assets
or  properties  may  be  bound.

          (b)     The  Company has furnished the Investor with information about
the  Company and such information is correct and complete as of the date of this
Subscription  Agreement.  If  there  should  be  any  material  change  in  such
information,  the  Company  will  immediately  furnish such revised or corrected
information  to  the  Investor.

          (c)     The  Company  has  made  the  foregoing  representations,
warranties,  covenants  and  agreements  knowing  that  they  shall  survive the
Investor's  acquisition  of  the  Shares.

     4.     Investor  Awareness.  The  Investor  acknowledges  its  complete
            -------------------
understanding  of  the  following  facts:

<PAGE>
          (a)     No  federal  or  state  agency  has passed upon the investment
quality  of  the Shares or made any finding or determination as to the fairness,
merits  or  risks  of  any  investment  in  them.

          (b)     There are substantial risks of loss of the investment incident
to  the  purchase  of  Shares.

          (c)     The  Shares  have not been registered under the Securities Act
or  any Blue Sky laws and must be held indefinitely unless they are subsequently
so  registered  or  exemptions  from such registration are available. The Shares
cannot  be sold without registration or other compliance with the Securities Act
and  applicable  Blue  Sky  laws.
     5.     Modification.  Neither this Agreement nor any provision hereof shall
            ------------
be waived, modified, discharged or terminated except by an instrument in writing
signed  by  the  party  against  whom  any  waiver,  modification,  discharge or
termination  is  sought.

     6.     Notices.  Any  notice, demand or other communication which any party
            -------
hereto  may be required, or may elect, to give anyone interested hereunder shall
be sufficiently given if (a) deposited, postage prepaid, in a United States mail
letter box, registered or certified mail, return receipt requested, addressed to
such  address  as  may  be  given  herein,  or  (b) delivered personally at such
address,  or  (c) delivered by fax transmission to a fax number provided by such
person  (who  confirms  receipt thereof).  The addresses and fax numbers for the
delivery  of  notices  are  as  follows:

     If to the Company:  New York Health Care, Inc.
                         1850 McDonald Avenue
                         Brooklyn, NY 11223
                         Tel: 718 375-6700
                         Fax: 718 375-4007

     with a copy to:     William J. Davis, Esq.
                         Scheichet & Davis, P.C.
                         800 Third Avenue - 29th  Floor
                         New York, NY 10022
                         Tel. (212) 688-3200
                         Fax:  (212) 371-7634

     If to the Investor: NexGen Bacterium, Inc.
                         Arango-Orillac Building, 2nd  Floor
                         East 54th Street
                         Panama City, Panama

     with a copy to:     The BioBalance Corp.
                         16 East 34th Street
                         New York, NY 10016
                         Tel: 212 679-7778
                         Fax: 212 679-7774

<PAGE>
     7.     Counterparts.  This  Subscription  Agreement  may be executed in any
            ------------
number  of  counterparts  and each of such counterparts shall, for all purposes,
constitute  one  agreement  binding  on  all  the  parties.

     8.     Binding  Effect.  Except  as  otherwise  provided  herein,  this
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Subscription  Agreement  shall  be  binding upon and inure to the benefit of the
parties and their respective heirs, executors, administrators, successors, legal
representatives  and  assigns.  If  the undersigned is more than one person, the
obligation  of  the  undersigned  shall  be joint and several and the covenants,
agreements,  representations,  warranties  and  acknowledgments herein contained
shall  be  deemed  to  be  made  by  and  be  binding  upon  each  such  person.

     9.     Entire  Agreement.  This  instrument  and  the Asset Agreement dated
            -----------------
this  date  contain  the  entire  agreement  of  the  parties  and  there are no
representations,  warranties, covenants or other agreements, except as stated or
referred  to  herein  and  therein.

     10.     Benefit  and  Transfer or Assignment.  Except as provided otherwise
             ------------------------------------
herein,  this  Subscription  Agreement  is not transferable or assignable by the
undersigned  without the written consent of the Company, which consent shall not
be  unreasonably  withheld.  No  such  written  consent  shall be required for a
transfer  or  assignment  by  the Investor of its rights or interests under this
Subscription  Agreement  to  a corporation or limited liability company in which
the  Investor  owns,  directly or indirectly, more than 50% of the capital stock
and  in  which  all  other  shareholders  are  accredited  investors.

     11.     Applicable  Law.  This  Subscription Agreement shall be governed by
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and  construed  in  accordance  with  the  laws of the State of New York without
giving  effect  to  that  state's  conflicts  of  laws  provisions.

INVESTOR:                                     NEW YORK HEALTH CARE, INC.
NEXGEN BACTERIUM, INC.

/s/Michel Marechal  Norma Nuezo               By:  /s/  Jerry Braun
-------------------------------                    ----------------
Michel Marechal  Norma Nuezo,                      Jerry Braun, President
General Attorneys
                                              Attest:

                                                   /s/  Jacob Rosenberg
                                                   --------------------
                                                   Jacob Rosenberg, Secretary

<PAGE><PAGE>
EXHIBIT 10.1

                            AMENDMENT TO 120 DAY NOTE

         This Amendment to 120 Day Note ("Amendment") is made and entered into
August 26, 2003 ("Effective Date"), by and between MicroIslet, Inc., Inc., a
Nevada corporation ("MicroIslet"), and John J. Hagenbuch, Trustee U/D/T dated
September 13, 1995 ("Lender"), with reference to the following facts:

                                    RECITALS

         A. MicroIslet executed in favor of Lender that certain 120 Day Note
(the "Note") dated April 11, 2003, in the original principal amount of Three
Hundred Thousand Dollars ($300,000).

         B. MicroIslet and Lender desire to modify the terms of the Note as
provided in this Amendment.

         NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto agree as
follows:

         1. The maturity date of the Note is hereby extended from August 9, 2003
to December 7, 2003.

         2. In consideration of Lender's extension of the maturity date of the
Note in Section 1, MicroIslet shall issue to Lender a 10-year warrant to
purchase fifty thousand (50,000) shares of MicroIslet common stock at a price
equal to the closing price of MicroIslet common stock as reported on the OTC
Bulletin Board on the Effective Date.

         3. Promptly following execution of this Amendment, Lender shall deliver
the Note to MicroIslet, which shall promptly after receipt of such Note issue a
new Note to Lender reflecting the maturity date set forth in Section 1 above,
but otherwise with identical terms to the Note. Upon delivery of the new Note to
Lender, MicroIslet shall mark the original Note "Cancelled" and retain such
Note.

         IN WITNESS WHEREOF, the parties hereto execute this Amendment as of the
Effective Date. Except as specifically set forth in this Amendment, the Note and
all terms and conditions thereof shall remain unchanged and in full force and
effect.

MicroIslet, Inc., a Nevada               John J. Hagenbuch, Trustee U/D/T dated
corporation                              September 13, 1995

By: /s/ John F. Steel IV                 By: /s/ John J. Hagenbuch
    ---------------------------------        -----------------------------------
    John F. Steel IV, Chief Executive        John J. Hagenbuch, Trustee
    Officer

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