Document:

<PAGE>

                                                                   Exhibit 10.13

                                LICENSE AGREEMENT
                                -----------------

         This Agreement ("Agreement"), effective January 1, 2001, is between the
University of Chicago, an Illinois not-for-profit corporation ("UNIVERSITY"),
having its principal office at 5640 South Ellis Avenue, Chicago, IL 60637 USA
and R2 Technology, Inc., a Delaware corporation ("LICENSEE") having its
principal office at 325 Distel Circle, Los Altos, CA 94022 USA. Each hereunder
may be referred to separately as the ("Party"), or together as the ("Parties").

                               Purpose and Intent
                               ------------------

         WHEREAS UNIVERSITY, under an agreement with its affiliated corporation,
ARCH Development Corporation ("ARCH") has the right to license the Licensed
Patents and other intellectual property owned by ARCH, and

         WHEREAS LICENSEE desires to obtain a license to commercialize certain
technology, and

         WHEREAS UNIVERSITY desires to enter into such a license to allow the
use of the technology for the commercialization of products designed to
facilitate computer aided detection and diagnosis of human diseases and
disorders, and

         WHEREAS the Parties have entered into this Agreement in good faith, and
agree as follows:

                                    Agreement
                                    ---------

1.       DEFINITIONS.  The following capitalized terms used in this Agreement
         -----------
shall mean:

         A.       "Affiliate" means, as to any person or entity, any other
person or entity, which directly or indirectly controls, is controlled by or is
under common control with the Party. Control shall mean the right to control, or
actual control of, management of such other entity, whether by ownership of
voting securities, by agreement, or otherwise.

         B.       "Calendar  Quartet"  means each of the four,  three-month
periods of each year ending on March 31, June 30,  September 31 and December 31.

         C.       "Copyrights" shall mean the copyrights as such term is defined
by statute and common law in the relevant Territory.

         D.       "Derivative Work" means all works developed by LICENSEE which
would be characterized as derivative works of the Licensed Software under the
United States Copyright Act of 1976, or subsequent revisions or amendments
thereof or successors thereto, specifically including, but not limited to,
translations, abridgements, condensations, recastings, transformations,
enhancements, new releases, or adaptations of the Licensed Software, or works

Confidential treatment has been requested for portions of this exhibit. The copy
filed herewith omits the information subject to the confidentiality request.
Omissions are designated as * * *. A complete version of this exhibit has been
filed separately with the Securities and Exchange Commission.

<PAGE>

consisting of editorial revisions, annotations, elaborations, or other
modifications of the Licensed Software.

         E.   "Designated Countries" shall mean those countries listed in
Schedule A, attached hereto, as such may be amended from time to time upon
mutual, written agreement of the Parties.

         F.   "Effective Date" means the date appearing in line 1 of this
Agreement.

         G.   "End User" means any person or other entity to whom the Licensed
Products are distributed under the Licensed Patents and/or Licensed Software,
who is not granted any rights to distribute the Licensed Patents and/or Licensed
Software to others.

         H.   "Field" means computer-aided diagnosis of diseases and/or
disorders in humans.

         I.   "Inventors" means the persons listed as inventors on the Licensed
Patents.

         J.   "Licensed Patents" means the patents and patent applications
listed on Schedule A attached hereto, including all divisions, continuations,
foreign patents and patent applications under the same UCHI numbers as such
patents and patent applications, and any valid patents which may issue therefrom
and any reissues, renewals, substitutions, or extensions of or to any such
patents or patent applications. "Licensed Patents" includes patent applications
and patents held in the name of ARCH since UNIVERSITY has the right by contract
to take any action respecting ARCH-owned technology, as an agent for ARCH.

         K.   "Licensed Product" means, 1) any product covered by the scope of
any Valid Claim contained in any Licensed Patent or a product made by a process,
method or technique covered by the scope of any Valid Claim in any Licensed
Patent or methods of using any product covered by the scope of any Valid Claim
contained in any Licensed Patent, and/or 2) any service or part of selling a
service, licensing a method of use or other means of deriving commercial benefit
from Licensed Patents, and/or 3) any product covered by the scope of the
Licensed Software or any product made by a process, method or technique covered
by the scope of the Licensed Software or methods of using any product covered by
the scope of the Licensed Software, and/or 4) any service or part of selling a
service, licensing a method of use or other means of deriving commercial benefit
from the Licensed Software.

         L.   "Licensed Software" means the computer software and related
documentation therefore provided to LICENSEE under this Agreement and identified
in Schedule B attached hereto and incorporated herein, which includes
maintenance releases and bug fixes.

         M.   "Net Sales" means: (1) the gross sales for Licensed Products,
less the following amounts directly chargeable to such sale: (a) customary
trade, quantity or cash discounts and rebates actually allowed and taken; (b)
amounts repaid or credited to customers on account of rejections or returns; and
(c) freight and other transportation costs, including insurance charges, and
duties, tariffs, sales and excise taxes and other governmental charges based
directly on sales, turnover or delivery of such Licensed Products and actually
paid or

                                       2

<PAGE>

allowed by LICENSEE and its Affiliates. Net Sales shall be determined in
accordance with generally accepted accounting principles consistently applied.
For Licensed Products consumed by LICENSEE or its Affiliates, the price used to
calculate Net Sales shall be equal to the average of the sales price of the same
or a substantially similar Licensed Product, whichever is relevant, sold to its
three largest customers during the same time period. Net Sales shall be
calculated on sales to End Users and not on sales between LICENSEE and its
Affiliates.

         N.       "Object Code" means any machine  executable  code that
pertains to, is derived from, or includes the Licensed Software or any part of
the Licensed Software.

         O.       "Royalties" means all amounts payable under Paragraphs 3.B.
of this Agreement.

         P.       "Sale" means any transaction in which an amount, trade, credit
or other consideration is made in exchange for any Licensed Products including
all revenue received from licensing of Licensed Software pursuant to Paragraph
2.A.2 below. Such revenue shall not include revenue earned by the LICENSEE and
its Affiliates from the provision of ancillary services, including, by way of
example, consulting services, customized application or implementation support,
installation, maintenance, technical support or warranty service.

         Q.       "Source Code" means the human readable form of Object Code.

         R.       "Technical Information" means any and all technical
information, know-how, data, processes, methods, protocols and procedures
relating to the Licensed Patents and or Licensed Software in the possession of
UNIVERSITY as of the date of this Agreement and which is considered confidential
within the meaning of Paragraph 9.A. of this Agreement.

         S.       "Territory" means worldwide.

         T.       "UCTech" means the University of Chicago Office of Technology
and Intellectual Property, UNIVERSITY's office that administers technology
transfer matters, including this Agreement.

         U.       "Valid Claim" means an issued claim of any unexpired patent or
a claim of any pending patent application which has not been held unenforceable,
unpatentable or invalid by a decision of a court or governmental body of
competent jurisdiction, in a ruling that is unappealable or unappealed within
the time allowed for appeal; which has not been rendered unenforceable through
disclaimer or otherwise; and which has not been lost through an interference
proceeding or irrecoverable failure to pay a maintenance fee. Notwithstanding
the foregoing, a claim of a pending patent application shall cease to be a Valid
Claim if no patent has issued on such claim on or prior to the fifth (5th)
anniversary of the date of filing of such utility application that may or may
not depend on the priority date of a provisional application, provided that such
claim shall once again become a Valid Claim on the issue date of a patent that
subsequently issues and includes such claim.

2.       GRANT OF LICENSE, DATA ACCESS AND RESERVATION OF RESEARCH RIGHTS
         ----------------------------------------------------------------

                                       3

<PAGE>

        A.       Grant.  UNIVERSITY hereby grants to LICENSEE:
                 -----

                 1.      A  non-exclusive  license to use the Licensed  Patents,
to make, have made, use, import, offer to sell and sell Licensed Products within
the Field and within the Territory;

                 2.      A non-exclusive license to use the Licensed Software to
make, have made, use, import, offer to sell and sell Licensed Products within
the Field and within the Territory. UNIVERSITY further grants to LICENSEE, a
non-exclusive license to create Derivative Works, and to use, reproduce, modify,
prepare compilations, distribute, perform and display publicly said Licensed
Software under the associated Copyrights thereto in the Territory without any
rights to grant further sublicenses. LICENSEE agrees either to destroy or return
the original and all existing copies of the Licensed Software to UNIVERSITY upon
expiration of this Agreement or upon earlier termination of the Agreement as
defined in Paragraphs 11.B and 11.C herein. The non-exclusive license shall not
include the right to grant sublicenses to others, except with respect to End
Users.

                 3.      A non-exclusive license to use the Technical
Information to make, have made, use, import, offer to sell and sell Licensed
Products within the Field and within the Territory.

                 4.      UNIVERSITY further grants to LICENSEE an exclusive
first option to negotiate an expanded commercial license for exclusive rights to
some or all the Licensed Patents and Licensed Software on a world-wide basis for
a period of sixty (60) days from July 24, 2001 ("Option Period"). Any exclusive
rights would be subject to pre-existing licenses concerning patent rights in
Japan. Upon notice by LICENSEE, UNIVERSITY and LICENSEE agree to negotiate in
good faith an agreement under mutually agreeable terms. Neither UNIVERSITY nor
LICENSEE will be obligated to enter into such an agreement and if no agreement
is executed before the end of the Option Period, UNIVERSITY will be free to
enter into licenses with third parties for the Licensed Patents and/or Licensed
Software and LICENSEE's rights to Licensed Patents and Licensed Software will
continue as defined in paragraph 2.A.1 through 2.A.3 inclusive.

                 5.      During the Option Period, both Parties agree not to
engage in discussions (written or verbal) with any third parties with respect to
grant or enforcement of any rights connected with this Agreement and or the 1996
license agreements dated December 23, 1996, except by mutual written agreement
by both Parties.

        B.       Other Rights.  No rights other than those provided in
                 ------------
Article 2.A, express or implied, are conveyed by UNIVERSITY. No right to
sublicense any rights granted the LICENSEE under this Agreement is hereby
granted or implied.

        C.       Data Access.  UNIVERSITY agrees to use its best efforts to
                 -----------
deliver copies of Licensed Software and Technical Information within thirty (30)
days after the execution of this Agreement.

        D.       Reservation of Rights. UNIVERSITY reserves for itself and the
                 ---------------------
University the worldwide right to use the Licensed Software, Technical
Information and to

                                       4

<PAGE>

practice the inventions claimed in the Licensed Patents to make, have made, use,
import, offer to sell and sell Licensed Products within the Field for all
educational and research purposes it may choose in its own discretion and
without any payment therefore. In addition, the inventions claimed in the
Licensed Patents were made with the use of funds from the United States
government. Therefore, there is reserved from the rights granted hereunder the
worldwide right of the United States government to use the Technical
Information, Licensed Software and to practice or have practiced the inventions
claimed in the Licensed Patents to make, have made, use, import, offer to sell
and sell Licensed Products in any field or use for its own purposes in such
manner as it deems fit without any payment therefore.

        E.    U.S. Laws. Any right granted in this Agreement greater than that
              ---------
permitted under Public Law 96-517 or Public Law 98-620 shall be subject to
modification as may be required to conform to the provisions of those laws.

   3.    License Fees, Royalties and Other Payments
         ------------------------------------------

        A.    Warrants. As partial consideration for the license granted in
              --------
Article 2 of this Agreement, concurrent with the execution of this Agreement,
LICENSEE shall issue to UNIVERSITY warrants giving UNIVERSITY the right, but not
the obligation, to purchase * * * shares of Series F preferred stock having
voting rights at a price of * * * per share. The warrants shall be fully vested
on the Effective Date. The warrants may be exercised at any time after * * * and
shall expire * * * years after the Effective Date.

        B.    Royalties. As partial consideration for the license granted in
              ---------
Article 2 of this Agreement, LICENSEE and/or its Affiliates shall pay UNIVERSITY
a Royalty equal to * * * of Licensed Products and/or products
developed from Derivative Works by LICENSEE and/or its Affiliates. Such
Royalties are due and payable each Calendar Quarter subject to Article 3.C. and
Article 5 below. Subsequent to the expiration of the last to expire of the
Licensed Patents, the Royalty due for all Licensed Products under the Licensed
Software will be * * * by LICENSEE and/or its Affiliates. Royalties
shall be payable only once with respect to Sales of Licensed Products regardless
of the number of Licensed Patents that cover a Licensed Product.

        C.    Calculation of Royalties. Royalties shall be payable in U.S.
              ------------------------
currency within forty-five (45) days after the end of each Calendar Quarter for
the term specified in Article 11.A. below, beginning with the Calendar Quarter
in which the first Sale of a Licensed Product occurs. Each payment shall be
accompanied by a statement showing Net Sales for each country in the Territory
and calculation of the Royalties due. There shall be deducted from all such
payments taxes required to be withheld by any governmental authority and
LICENSEE shall provide copies of the receipt for such taxes to UNIVERSITY along
with each Royalty payment. Any necessary conversion of currency into United
States dollars shall be made at the applicable rate of exchange of Citibank,
N.A., in New York, New York, on the last day of the Calendar Quarter for which
the Royalty is paid. All payments under this Agreement shall be

--------

* * *Certain information on this page has been omitted and filed separately with
the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions

                                       5

<PAGE>

made by check payable to the University of Chicago and sent to the UCTech at the
address in Article 14.D.

        4.    Records. LICENSEE shall, and shall cause its Affiliates, to keep
              -------
full and accurate books and records in sufficient detail so that sums due
UNIVERSITY hereunder can be properly calculated. Such books and records shall be
maintained for at least three (3) years after the Royalty reporting period(s) to
which they relate. During the term hereof and for three (3) calendar year
thereafter, LICENSEE shall permit, and shall cause its Affiliates to permit,
accountants designated by UNIVERSITY, to whom LICENSEE has no reasonable
objection, to examine its books and records for the purpose of verifying the
accuracy of the written statements submitted by LICENSEE and sums paid or
payable. UNIVERSITY may conduct such examination no more than once in any
calendar year. After completion of any such examination, UNIVERSITY shall
promptly notify LICENSEE in writing of any proposed modification to LICENSEE's
statement of sums due and payable. If LICENSEE accepts such modification, or if
the Parties agree on other modifications, one Party shall promptly pay or credit
the other in accordance with such resolution. Such examination shall be made at
the expense of UNIVERSITY, except that if such examination discloses a
discrepancy of five percent (5%) or more in the amount of Royalties and other
payments due UNIVERSITY, then LICENSEE shall reimburse UNIVERSITY for the cost
of such examination and pay the amount due with interest from the date at which
such amount was due as provided in Article 5 hereof.

        5.    Overdue Payments. Any payments due to UNIVERSITY under this
              ----------------
Agreement, including patent cost reimbursement shall, if not paid when due under
the terms of this Agreement, bear simple interest at the lower of the prime rate
of interest (as published by Citibank, N.A. on the date such payment is due)
plus five percent (5%) or the highest rate permitted by law, calculated on the
basis of a 360-day year for the number of days actually elapsed, beginning on
the due date and ending on the day prior to the day on which payment is made in
full. Interest accruing under this Paragraph shall be due to UNIVERSITY on
demand or upon payment of past due amounts, whichever is sooner. The accrual or
receipt by UNIVERSITY of interest under this Paragraph shall not constitute a
waiver by UNIVERSITY of any right it may otherwise have to declare a default
under this Agreement or to terminate this Agreement.

        6.    Prosecution and Maintenance of Patents: Patent Costs
              ----------------------------------------------------

              A.    Prosecution and Maintenance. UNIVERSITY shall be solely
                    ---------------------------
responsible for the preparation, filing, prosecution and maintenance of the
Licensed Patents. LICENSEE agrees to cooperate, and agrees to cause its
Affiliates to cooperate, with UNIVERSITY in the preparation, filing, prosecution
and maintenance of the Licensed Patents by disclosing such information as may be
necessary for the same and by promptly executing such documents as UNIVERSITY
may reasonably request in connection therewith. LICENSEE and its Affiliates
shall bear their own costs in connection with their cooperation with UNIVERSITY
under this Paragraph. UNIVERSITY agrees to file and pursue applications in the
Designated Countries as long as LICENSEE is in material compliance regarding its
patent cost reimbursement responsibilities under Article 6.B.

                                       6

<PAGE>

        B.    Patent Costs. For all Licensed Patents in Designated Countries
              ------------
for which non-exclusive rights are granted, LICENSEE agrees to pay, * * * of all
past and future third party fees and expenses incurred by UNIVERSITY in
obtaining and maintaining Licensed Patents as listed on Schedule A - * * *.
Payment for fees and expenses incurred prior to execution of this Agreement will
be invoiced to LICENSEE upon execution of this Agreement and LICENSEE agrees to
pay such invoices within thirty (30) days of the execution of this Agreement.
Payment for fees and expenses incurred after the execution of the Agreement will
be invoiced to the LICENSEE on a Calendar Quarterly basis and LICENSEE agrees to
pay such invoices within thirty (30) days of receipt. Should the Licensed
Patents under * * * be further licensed by UNIVERSITY to more than two other
third parties the material obligation of the LICENSEE to pay ongoing patent
costs under this paragraph will be recalculated to reflect a reduced share of
the patent cost responsibility.

        C.    Failure to Pay Patent Costs. If LICENSEE declines or fails to make
              ---------------------------
advance payments or pay or reimburse UNIVERSITY for all or any portion of the
patent fees and expenses (including maintenance fees) as required by Paragraph
6.13 for any application or patent, LICENSEE's rights with respect to all such
applications and patents for which LICENSEE fails to make advance payments or
does not reimburse UNIVERSITY shall terminate effective sixty (60) days after
written notice from UNIVERSITY requesting such payment, unless payment in full
is made within such time. Such notice can be sent by UNIVERSITY at any time
after the expiration of the thirty (30) days provided in Paragraph 6.B for
payment of invoices if LICENSEE has not objected to the amount invoiced or in
the case of advance payments, any time after the date fifteen (15) days before
the payment must be made by UNIVERSITY to a third party. Not withstanding the
foregoing, failure to pay patent costs hereunder is a material breach of this
Agreement and the UNIVERSITY has the right to terminate the Agreement as defined
in 11.B.

   7.   Due Diligence
        -------------

        A.    Commercialization Plans. LICENSEE shall provide UNIVERSITY with
              -----------------------
its strategic and detailed plans for the commercialization of the Licensed
Products. Such plans shall include research and development plans, product
milestones and related timetable schedules, government or regulatory timetables
and sales and marketing plans. LICENSEE will update these plans at least on an
annual basis until a Licensed Product is offered for Sale.

        B.    Progress Report. LICENSEE will provide UNIVERSITY with LICENSEE's
              ---------------
quarterly report to stockholders beginning with the Calendar Quarter ended
September 30, 2001. Such report will include the Company's financial performance
for the Calendar Quarter. LICENSEE agrees to immediately notify UNIVERSITY in
writing when Licensed Products are first sold and when LICENSEE's obligation to
begin making running Royalty payments begins.

        C.    LICENSEE Efforts. LICENSEE shall commence sales of Licensed
              ----------------
Products that incorporate or utilize Licensed Patents, Copyrights, Licensed
Software or

----------------
* * *Certain information on this page has been omitted and filed separately with
the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions

                                       7

<PAGE>

Technical Information by * * *. If LICENSEE has not commenced sales of Licensed
Products by * * *, LICENSEE shall pay an annual License Maintenance fee of * * *
dollars on that date and each anniversary of that date thereafter until
commercial sales commence. Such License Maintenance fee is nonrefundable, but
shall be creditable to royalties due on future commercial sales.

    8.  All Patents, No Other Warranties: Indemnification; Risk; and Insurance
        ----------------------------------------------------------------------

        A.    All Patents. UNIVERSITY represents and warrants that it shall not
              -----------
assert its rights to any of its existing patents or patents that issue from
patent applications pending as of the Effective Date against LICENSEE or its
customers based upon LICENSEE's use, importation, offer for sale or sale or the
LICENSEE's customers' use of Licensed Products. Such warranty applies only to
those patents or patent applications filed or issued at the execution of the
Agreement not identified by the UNIVERSITY to LICENSEE.

        B.    Disclaimer of Warranties. Except as provided in Paragraph 8.A.,
              ------------------------
UNIVERSITY makes no representations or warranties of any kind, express or
implied, with respect to the Licensed Software or the invention(s) claimed in
the Licensed Patents or with respect to the Licensed Patents themselves,
Derivative Works or Technical Information, including but not limited to, any
representations or warranties about (i) the validity, scope or enforceability of
any of the Licensed Patents; (ii) the accuracy, safety or usefulness for any
purpose of any information provided by UNIVERSITY to LICENSEE with respect to
the Licensed Software or the invention(s) claimed in the Licensed Patents or
with respect to the Licensed Patents themselves or Derivative Works; (iii)
whether the use of the Licensed Software or the practice of any claim contained
in any of the Licensed Patents will or might infringe a patent or other
intellectual property right owned or licensed by a third party; (iv) the
patentability of any invention claimed in the Licensed Patents; or (v) the
accuracy, safety, or usefulness for any purpose of any process made or carried
out in accordance with or through the use of the Licensed Software, Derivative
Works or the Licensed Patents.

        C.    Indemnification. LICENSEE agrees to indemnify, defend and hold
              ---------------
harmless UNIVERSITY, its Affiliates and all trustees, directors, officers,
employees, fellows and agents of any of the foregoing (including UNIVERSITY and
its Affiliates, each an "Indemnified Person") from and against any and all
claims, demands, loss, damage, penalty, cost or expense (including attorneys and
witnesses' fees and costs) of any kind or nature, arising from the development,
production, use, sale or other disposition of Licensed Products or use and/or
examination of Licensed Patents, Licensed Software, Derivative Works and
Technical Information and all activities associated therewith by LICENSEE,
including clinical trials, or any use of information provided by UNIVERSITY to
LICENSEE. LICENSEE agrees not to sue any Indemnified Person in connection with
the use and/or examination of the Licensed Patents, Licensed Software,
Derivative Works and Technical Information and all activities associated
therewith. UNIVERSITY shall be entitled to participate at their option and
expense through counsel of their own selection, and may join in any legal
actions related to any such claims, demands, losses, damages, costs, expenses
and penalties. LICENSEE shall not enter into any

----------------
* * *Certain information on this page has been omitted and filed separately with
the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions

                                       8

<PAGE>

settlement affecting any rights or obligations of any Indemnified Person or
which includes an express or implied admission of liability, negligence or
wrongdoing by any Indemnified Person, without the prior written consent of such
indemnified Person.

        D.    Assumption of Risk. The entire risk as to the performance, safety
              ------------------
and efficacy of Licensed Products, Licensed Software, Derivative Works,
Technical Information or any invention claimed in the Licensed Patents is
assumed by LICENSEE. Indemnified Persons shall not, except for their intentional
misconduct or gross negligence, be responsible or liable for any injury, loss,
or damage of any kind, including but not limited to direct, indirect, special,
incidental or consequential damages or lost profits to LICENSEE or any of the
foregoing, or for any such injury, loss or damage to any other individual or
entity, regardless of legal theory based on the use and/or examination of
Licensed Patents, Licensed Software, Derivative Works and Technical Information
and all activities associated therewith. The above limitations on liability
apply even though the Indemnified Person may have been advised of the
possibility of such injury, loss or damage. LICENSEE shall not make any
agreements, statements, representations or warranties or accept any liabilities
or responsibilities whatsoever with regard to any person or entity which are
inconsistent with this Paragraph.

        E.    Insurance. LICENSEE agrees and agrees to cause its Affiliates to
              ---------
maintain liability insurance that shall cover any claims for bodily injury,
property, or other damage alleged to relate to the use, including clinical
trials, of Licensed Patents, Licensed Software, Derivative Works, Technical
Information and Licensed Products. LICENSEE shall list UNIVERSITY and its
Affiliates, at LICENSEE's or Affiliates' expense, whichever is relevant, as
additional named insureds under each liability insurance policy (including
excess or umbrella liability policies) that LICENSEE or its Affiliates shall
have or shall obtain, that includes any coverage of claims relating to Licensed
Products. Such insurance shall be primary and noncontributory to any insurance
UNIVERSITY and its Affiliates may have. At UNIVERSITY's request, LICENSEE will
supply UNIVERSITY from time to time with copies of each such policy, and will
notify UNIVERSITY in writing at least thirty (30) days prior to any termination
of or change in coverage under any such policies.

   9.   Confidentiality and Publications.
        --------------------------------

        A.    Confidential Information. All information submitted by one Party
              ------------------------
to the other concerning the Licensed Products, the Licensed Patents, the
invention(s) claimed in the Licensed Patents, the Licensed Software and the
Technical Information shall be considered as confidential ("Confidential
Information") and shall be utilized by the receiving Party only pursuant to the
licenses granted hereunder. During the term of this Agreement and for a period
of ten (10) years thereafter, neither Party shall disclose to any third party
any Confidential Information received from the other Party without the specific
written consent of such Party. The foregoing shall not apply where Confidential
Information a) was or becomes public through no fault of the receiving Party, b)
was, at the time of receipt, already in the possession of the receiving Party as
evidenced by its written records, c) was obtained from a third party legally
entitled to use and disclose the same, or d) is required by law to be disclosed
to a governmental agency.

                                       9

<PAGE>

        B.    Publications. UNIVERSITY shall provide to LICENSEE copies of any
              ------------
proposed written publication by UNIVERSITY containing any of the LICENSEE's
Confidential Information and, to the extent UNIVERSITY is aware of them,
proposed publications containing any of the LICENSEE's Confidential Information
by the Inventor(s). LICENSEE agrees to provide copies of any proposed written
publication of LICENSEE and/or its Affiliates to UNIVERSITY. The Parties shall
provide copies of such proposed written publications at least ninety (90) days
in advance of publication in order to protect potentially patentable subject
matter. The receiving Party may request, and the disclosing Party agrees, that
publication will be withheld for an additional thirty (30) days, if required, to
obtain patent protection. The receiving Party may object to such proposed
publication or disclosure on the grounds that the publication contains
Confidential Information of the objecting Party. At the request of the objecting
Party, Confidential Information of such Party shall be deleted from the
publication.

   10.  Infringement. If a third party infringes any patent included in the
        ------------
Licensed Patents within the Field, UNIVERSITY shall have the right but not
the obligation, at its sole discretion, to institute and prosecute an action or
proceeding to abate such infringement and to resolve such matter by settlement
or otherwise. LICENSEE shall cooperate fully by joining as a party plaintiff if
required to do so by law to maintain such action and by executing and making
available such documents as UNIVERSITY may reasonably request. If the amounts
recovered by UNIVERSITY exceed its reasonable third party out-of-pocket fees and
expenses, UNIVERSITY agrees to pay LICENSEE for its and its Affiliates'
reasonable out-of-pocket third party expenses incurred by it in cooperating in
the action or proceeding. Except as specifically provided in this Paragraph,
UNIVERSITY shall have the right to retain all amounts recovered of every kind
and nature. Amounts recovered by UNIVERSITY shall not be considered Net Sales
under this Agreement and shall not give rise to Royalty payments under
Article 3.

   11.  Termination
        -----------

        A.    Term. Unless terminated earlier pursuant to Paragraphs 11.B or
              ----
11.C, this Agreement shall terminate on the later of (i) the expiration of the
licensed intellectual property rights hereto.

        B.    UNIVERSITY's Right to Terminate. UNIVERSITY shall have the right
              -------------------------------
to terminate this Agreement as follows, in addition to all other available
remedies:

              1.   If LICENSEE fails to pay any Royalty or other payment when
due, this Agreement shall terminate effective sixty (60) days after UNIVERSITY's
written notice to LICENSEE to such effect, unless LICENSEE makes such payment
within the sixty (60) days.

              2.   If LICENSEE fails to comply with any other material
obligation of this Agreement, this Agreement shall terminate effective sixty
(60) days after UNIVERSITY's written notice to LICENSEE describing such failure,
unless LICENSEE cures such failure within the sixty (60) days.

              3.   If LICENSEE shall have filed by or against it a petition
under any bankruptcy or insolvency law and such petition is not dismissed within
sixty (60) days of its filing, or if LICENSEE makes an assignment of all or
substantially all of its assets for the benefit

                                       10

<PAGE>

of its creditors UNIVERSITY may terminate this Agreement by written notice
effective as of the (i) date of filing by LICENSEE of any such petition, (ii)
date of any such assignment to creditors, or (iii) end of the sixty (60) days if
a petition is filed against it and not dismissed by such time, whichever is
applicable.

              4.    If LICENSEE shall be dissolved, liquidated or otherwise
ceases to exist, other than for reasons specified in Paragraph 11.B.(3) above,
this Agreement shall automatically terminate as of (i) the date articles of
dissolution or a similar document is filed on behalf of LICENSEE with the
appropriate government authority or (ii) the date of establishment of a
liquidating trust or other arrangement for the winding up of the affairs of
LICENSEE.

        C.    LICENSEE's Right to Terminate. LICENSEE may terminate this
              -----------------------------
Agreement at any time by giving UNIVERSITY ninety (90) days prior written
notice.

        D.    Survival. All causes of action accruing to either party under this
              --------
Agreement shall survive termination for any reason, as well as (1) LICENSEE's
obligation under Article 3 and Paragraph 6.B to pay Royalties and Patent Costs
accrued prior to the date of termination and which were not paid or payable
before termination, along with LICENSEE's obligation to report Net Sales and to
keep records as set forth in Article 4 and Articles 8 and 9.

   12.  Advertising
        -----------

        A.    Each Party agrees not to use (and LICENSEE agrees to prohibit its
              ----
Affiliates from using) the name of the other Party (and, LICENSEE agrees not to
use, the names of the University and the Inventors under the Licensed Patents)
in any commercial activity, marketing, advertising or sales brochures except
with the prior written consent of the other Party, which such consent may be
granted or withheld in such Party's sole and complete discretion, provided that,

              1.    with the prior written consent of UNIVERSITY not
unreasonably withheld or delayed, LICENSEE may disclose to the banks, commercial
finance institutions or prospective investors from which LICENSEE may attempt to
obtain debt or equity financing (i) the names of UNIVERSITY, the University and
the Inventor(s) under the Licensed Patents, (ii) the identities of UNIVERSITY,
the University and the Inventor(s) under the Licensed Patents and their
respective connections to, and ownership interests in, the Licensed Patents, and
(iii) the identity of the Inventor under the Licensed Patents as a founder and
scientific advisor to LICENSEE in advertising and sales materials; and

              2.    with the prior written consent of LICENSEE not unreasonably
withheld or delayed, UNIVERSITY or its Affiliates may disclose (i) the name of
LICENSEE and (ii) the existence of this Agreement.

   13.  Miscellaneous
        -------------

        A.    United States Manufacture. LICENSEE agrees that any Licensed
              -------------------------
Products that are sold in the United States of America will be manufactured
substantially in the United States of America as required by 35 United States
Code Section 204.

                                       11

<PAGE>

        B.    Export Regulations. To the extent that the United States Export
              ------------------
Control Regulations are applicable, neither LICENSEE nor UNIVERSITY shall,
without having first fully complied with such regulations, (i) knowingly
transfer, directly or indirectly, any unpublished technical data obtained or to
be obtained from the other party hereto to a destination outside the United
States, or (ii) knowingly ship, directly or indirectly, any product produced
using such unpublished technical data to any destination outside the United
States.

        C.    Entire Agreement, Amendment, Waiver. This Agreement together with
              -----------------------------------
the Schedules attached constitute the entire agreement between the Parties
regarding the subject matter hereof, and supersedes all prior written or oral
agreements or understandings (express or implied) between them concerning the
same subject matter. This Agreement may not be amended or modified except in a
writing signed by duly authorized representatives of each Party. No waiver of
any default hereunder by either Party or any failure to enforce any rights
hereunder shall be deemed to constitute a waiver of any subsequent default with
respect to the same or any other provision hereof.

        D.    Notice. Any notice required or otherwise made pursuant to this
              ------
Agreement shall be in writing, sent by registered or certified mail properly
addressed, or by facsimile with confirmed answer-back, to the other Party at the
address set forth below or at such other address as may be designated by written
notice to the other Party. Notice shall be deemed effective three (3) business
days following the date of sending such notice if by mail, on the day following
deposit with an overnight courier, if sent by overnight courier, or upon
confirmed answer-back if by facsimile.

If to UNIVERSITY:                          If to LICENSEE:

UCTech                                     R2 Technology, Inc.
5640 South Ellis Ave, Suite 405            325 Distel Drive
Chicago, IL 60637                          Los Altos, California 94022
Attention:  Director of Licensing          Attention: Chief Financial Officer

        E.    Assignment. This Agreement shall be binding on the Parties hereto
              ----------
and upon their respective successors and assigns. Either Party may at any time,
upon written notice to the other Party, assign or delegate to a successor to all
or substantially all of its business any of its rights and obligations
hereunder, provided that, any such assignment or delegation shall in no event
relieve either Party of its primary responsibility for the same. Except as
provided in the preceding sentence, LICENSEE may not assign or delegate any
right or obligation hereunder without the prior written consent of UNIVERSITY,
which consent shall not be unreasonably withheld, and any attempted assignment
or deletion in violation thereof shall be void. UNIVERSITY may assign this
Agreement at any time to any third party on written notice to LICENSEE. In such
event, the assignee shall be substituted for UNIVERSITY as a party hereto, and
UNIVERSITY shall no longer be bound hereby.

        F.    Governing Law. The interpretation and performance of this
              -------------
Agreement shall be governed by the laws of the State of Illinois applicable to
contracts made and to be fully performed in that state.

                                       12

<PAGE>

         IN WITNESS WHEREOF, the Parties hereto have caused this Agreement to be
executed by their respective duly authorized officers or representatives and,
signed below,

UNIVERSITY                                      R2 Technology, Inc.

By: /s/ A.E.P. Thomas                           By: /s/ Kevin Davidge
    -----------------                                -----------------

Name: A.E.P. Thomas                             Name: Kevin Davidge
      -------------                                   --------------------

Title: Director of Technology Transfer, UC      Title: CFO
Tech                                                   ---

Date: 7/29/01                                   Date: 7/24/01
      ----------------------------------------        --------------------

                                       13

<PAGE>

                                   Schedule A
                                   ----------

                                Licensed Patents
                                ----------------

-------------------------------------------------------------------------------
  UCHI   Title         US Patent #            Filing Date        Designated
                       or                     or                  Countries
                       Serial Number          Issue Date
-------------------------------------------------------------------------------
* * *
-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

-------------------------------------------------------------------------------

----------------------------

***Certain information on this page has been omitted and filed separately with
the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions.

<PAGE>

                                  SCHEDULE B
                                  ----------

                   LICENSED SOFTWARE AND TECHNICAL INFORMATION
                   -------------------------------------------

-------------------------------------------
* * *
-------------------------------------------

-------------------------------------------

-------------------------------------------

-------------------------------------------

-------------------------------------------

------------------------------
* * *Certain information on this page has been omitted and filed separately with
the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions.

<PAGE>

July 25, 2001

Kurt Rossmann Laboratories
Department of Radiology
The University of Chicago

An Offer for Unrestricted Gift
------------------------------

R2 Technologies Inc. is pleased to send the total amount * * * as a unrestricted
gift to support the research activities related to computer-aided diagnosis
(CAD) at the Kurt Rossmann Laboratories, Department of Radiology, the University
of Chicago. We hope that this fund will be useful in your research.

The unrestricted gift will be paid by check drawn on a U.S. bank, made out to
the University of Chicago, Department of Radiology, Kurt Rossmann Laboratories.
The check will be sent to UCTech, 5640 South Ellis Avenue, Suite 405, Chicago IL
60637. Attn: Director of Licensing. UCTECH will acknowledge receipt and forward
the check to the Chairman of the Department of Radiology.

R2 Technology, Inc.
-------------------

Signature: /s/ Kevin Davidge
           -----------------------------------------

By: Kevin Davidge
    ------------------------------------------------

Title: VP and CFO
       ---------------------------------------------

Date: 7/25/01
      ----------------------------------------------

Effective Date: 7/24/01
               -------------------------------------

-----------------------------------
* * *Certain information on this page has been omitted and filed separately
with the Securities and Exchange Commission. Confidential treatment has been
requested with respect to the omitted portions.<PAGE>

                                                                   Exhibit 10.16

Mediacom Termination and Release Agreement

                              TERMINATION AGREEMENT
                              ---------------------

This Termination Agreement (hereinafter "Termination Agreement") is entered into
as of the 31/st/ day of January, 2001, by and between Mediacom LLC ("Mediacom")
and SoftNet Systems, Inc. ("SoftNet"). Mediacom and SoftNet will be referred to
collectively as "the Parties."

WHEREAS, the Parties entered into a Stock Purchase Agreement and a Stockholder
Agreement on or about November 4, 1999 (collectively, the "Agreement"), a true
and correct copy of said Agreement being attached hereto and incorporated herein
in full as Exhibit A;
           ---------

WHEREAS, the Parties desire to terminate the Agreement and all obligations
thereunder without admission or denial of breach or liability by either party
thereto;

NOW THEREFORE, the Parties in consideration of the following conditions,
covenants and promises, agree as follows:

1.       The Parties agree that the terms of this Termination Agreement are and
         shall remain CONFIDENTIAL and that any disclosure of same, without the
         written consent of the other Party, will be a material breach of this
         Termination Agreement. Capitalized terms not otherwise defined herein
         shall be defined according to the Agreement.

2.       SoftNet absolutely and unconditionally guarantees the prompt and
         punctual performance of all obligations of ISP Channel, Inc. ("ISP
         Channel") under the Transition Agreement of even date herewith between
         ISP Channel and Mediacom. In the event of a default of any such
         obligation by ISP Channel, Mediacom having made written demand on ISP
         Channel which demand has gone unsatisfied for a period of 48 hours,
         Mediacom shall have the right to demand (without any further attempt at
         collection) that SoftNet satisfy the unfulfilled obligation by
         providing written notice detailing the failure of performance by ISP
         Channel, and SoftNet shall fulfill such obligation within 48 hours
         thereafter.

         (a)      SoftNet hereby warrants and represents: (i) it has all
                  requisite corporate power and corporate authority to execute
                  and deliver this Guarantee and to perform its obligations
                  hereunder; (ii) the execution and delivery of this Guarantee
                  by SoftNet in accordance with the terms hereof, and the
                  performance of the transactions contemplated hereunder by
                  SoftNet in the circumstances set forth above, have been duly
                  and validly approved by its Board of Directors and by all
                  other corporate action, if any, necessary on behalf of
                  SoftNet; (iii) the obligations imposed on SoftNet under this
                  Guarantee are valid, legal and binding obligations of SoftNet
                  enforceable against it in accordance with their terms.; (iv)
                  the execution and delivery of this Guarantee and the
                  consummation of the transactions contemplated hereby by
                  SoftNet will not (A) violate any law, regulation, order or
                  decree, or (B) conflict with or result in any breach of, or
                  constitute a default under, SoftNet's corporate charter or
                  bylaws, or any agreement or contract to which it is a party or
                  by which it or its assets are bound or affected.

         (b)      SoftNet hereby waives notice of acceptance of this Guaranty.
                  Mediacom and ISP Channel may at any time, and from time to
                  time, without notice to or consent of SoftNet and without
                  impairing or releasing the obligations of SoftNet hereunder:
                  (i) modify, release, exchange, extend or renew any obligation
                  or liability of ISP Channel under the Transition Agreement,
                  (ii) exercise or refrain from exercising any rights under the
                  Transition Agreement and (iii) compromise or subordinate any
                  obligation or liability of ISP Channel. Any other suretyship
                  defenses are hereby waived by SoftNet.

3.       With respect to the 3,500,000 shares of SoftNet common stock issued
         under the Agreement to Mediacom (the "Shares"), the parties agree as
         follows: On January 31, 2001, Mediacom shall return, transfer and
         assign to SoftNet 1,300,000 Shares (the "Returned Shares") and shall
         retain and shall continue as the absolute and unconditional registered
         and beneficial holder of the remaining 2,200,000 Shares (the "Retained
         Shares"). SoftNet has caused 1,116,518 of the Retained Shares to be
         registered under the Securities Act and the remaining 1,083,482 are
         Unrestricted Shares which will continue to be subject to the

<PAGE>

         provisions of the Registration Rights Agreement between the Parties,
         dated November 4, 1999, which Registration Rights Agreement shall
         remain in full force and effect in accordance with its terms. On
         January 31, 2001, SoftNet will deliver to Mediacom certificates for the
         Retained Shares and Mediacom will deliver to SoftNet certificates for
         the Returned Shares. The certificates for the Retained Shares that have
         been registered shall not bear any restrictive legends whatsoever and
         shall be accompanied by a Certificate signed both by the Chief
         Executive Officer and General Counsel of SoftNet to the effect that
         such Retained Shares have been registered pursuant to a Registration
         Statement which has been declared effective by the Securities Exchange
         Commission. The remaining Retained Shares may bear a legend to the
         effect that they have not been registered under the Securities Act of
         1933 and are subject to a Registration Rights Agreement between
         Mediacom LLC and SoftNet Systems Inc. dated November 4, 1999.

4.       The Agreement is hereby terminated in all respects. The terms of the
         Agreement shall be of no further force and effect and are superseded in
         full by this Termination Agreement.

5.       Mediacom hereby releases and forever discharges SoftNet in every one of
         its capacities, from any and all actions, claims, demands, suits, fees,
         costs and liabilities whatsoever, whether known or unknown, presently
         existing, whether or not asserted, and whether found in fact or law or
         in equity, existing at any time, including but not limited to those
         that may have arisen under the Agreement and SoftNet's Guarantee of ISP
         Channel, Inc.'s obligations under the Affiliate Agreement, other than
         those created by this Termination Agreement and the Termination
         Agreement.

6.       SoftNet hereby releases and forever discharges Mediacom in every one of
         its capacities, from any and all actions, claims, demands, suits, fees,
         costs and liabilities whatsoever, whether known or unknown, presently
         existing, whether or not asserted, and whether found in fact or law or
         in equity, existing at any time, including but not limited to those
         that may have arisen under the Agreement, other than those created by
         this Termination Agreement and the Transition Agreement.

7.       As further consideration for this Termination Agreement, SoftNet and
         Mediacom acknowledge, represent and warrant that the matters herein
         released are not limited to matters that are known or disclosed. The
         Parties hereby acknowledge that they have read, understand and have had
         counsel explain to them, and hereby waive any and all right and benefit
         it now has or may have in the future, conferred upon it by Section 1542
         of the Civil Code of the State of California, which provides:

         "A GENERAL RELEASE DOES NOT EXTEND TO THE CLAIMS WHICH THE CREDITOR
         DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF EXECUTING
         THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY AFFECTED HIS
         SETTLEMENT WITH THE DEBTOR."

8.       The Parties agree that this Termination Agreement is the result of a
         compromise and that it shall not be deemed or construed to admit or
         deny liability.

9.       The Parties hereby represent and warrant that they are the owners of
         the claims being released hereby, they have not previously assigned or
         transferred or purported to transfer any claim or portion thereof that
         is released hereby to any other person or entity that is not a
         signatory of this Termination Agreement. The Parties hereby represent
         and warrant that there are no liens, or claims of liens, or assignments
         in law or equity or otherwise, of or against the claims released
         herein; and that they are fully entitled to give this complete release
         and discharge. The Parties will indemnify and save harmless each other
         from any loss, claim, lien, expense, demand, or cause of action of any
         kind or character through the assertion by any party or stranger hereto
         of a claim relating to the warranty set forth in this paragraph.

10.      The Parties acknowledge that this Termination Agreement, together with
         the Registration Agreement and Transition Agreement, constitutes the
         entire agreement and understanding between the Parties with respect to
         the subject matter hereof and supersedes all prior discussions,
         documents, agreements and prior course of dealing. between the parties.
         The parties acknowledge that no representations or promises concerning
         the terms and effects of this Termination Agreement have been made,
         other than those contained herein, and in executing this Termination
         Agreement, they do not rely, and have not relied, upon any
         representations or statements not set forth herein with regard to the
         subject matter, basis or effect of this Termination Agreement or
         otherwise.

<PAGE>

11.      The Parties acknowledge that they have been represented with respect to
         this Termination Agreement by legal counsel of their own choosing, that
         they have read this Termination Agreement and had it fully explained to
         them by counsel, and are fully aware its contents and legal effects,
         and agree that no presumption as to the interpretation of this
         Termination Agreement shall arise based upon the identity of the
         drafter of this Termination Agreement or any of its provisions.

12.      Any dispute between the Parties arising out of or in connection with
         this Termination Agreement, which cannot be settled amicably, shall be
         finally settled by the American Arbitration Association under its
         Commercial Arbitration Rules. Any such arbitration shall take place in
         New York, New York.

13.      This Termination Agreement shall be governed and construed in
         accordance with the laws of Delaware without reference to conflict of
         law principles.

14.      In any action to enforce this Termination Agreement the prevailing
         party will be entitled to costs and attorney's fees.

15.      In the event that any provision of this Termination Agreement is held
         by a court of competent jurisdiction to be unenforceable, such
         provision shall be limited or eliminated to the extent necessary so
         that this Termination Agreement shall remain in full force and effect
         and enforceable.

16.      Any amendment or modification to this Termination Agreement may occur
         only with the written consent of both of the parties.

17.      This Termination Agreement may be executed in one or more counterparts,
         each of which shall be deemed an original, and all of which together
         shall constitute one and the same instrument.

IN WITNESS WHEREOF, the Parties have executed this Termination Agreement. All
signed copies of this Termination Agreement shall be deemed originals.

Mediacom LLC

By: _______________________________
Name: Mark E. Stephan
Title: Senior Vive President, Chief Financial Officer and Treasurer
Dated: ____________________________

SOFTNET SYSTEMS, INC.

By: _______________________________
Steven M. Harris
Senior Vice President
Dated: ____________________________

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00032-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00032-of-00352.parquet"}]]