Document:

Sixth Amendment to Loan and Security Agreement

 Exhibit 10.1 
 SIXTH AMENDMENT 
 TO 
 LOAN AND SECURITY AGREEMENT 
 THIS SIXTH
AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into this 2nd day of January, 2007, by and between Silicon Valley Bank (“Bank”) and Pharsight Corporation, a Delaware corporation (“Borrower”)
whose address is 321 East Evelyn Avenue, 3 rd Floor, Mountain View, California 94041. 
 RECITALS 
 A. Bank and Borrower
have entered into that certain Amended and Restated Loan and Security Agreement dated as of May 27, 2004, as amended by that certain Loan Modification Agreement by and between Bank and Borrower dated as of February 10, 2005, as amended by
that certain Loan Modification by and between Bank and Borrower dated as of May 26, 2005, as amended by that certain Loan Modification Agreement by and between Bank and Borrower dated as of June 20, 2005, by that certain Fourth Amendment
to Loan and Security Agreement by and between Bank and Borrower dated as of July 14, 2005 and as further amended by that certain Fifth Amendment to Loan and Security Agreement by and between Bank and Borrower dated as of June 12, 2006 (as
the same may from time to time be further amended, modified, supplemented or restated, the “Loan Agreement”). 
 B. Bank has
extended credit to Borrower for the purposes permitted in the Loan Agreement. 
 C. Borrower has requested that Bank amend the Loan
Agreement to (i) lower the interest rate payable on the Advances, Term Loan 2 and Equipment Advances, (ii) extend the Revolving Maturity Date and (iii) make certain other revisions to the Loan Agreement as more fully set forth herein.

 D. Bank has agreed to so amend certain provisions of the Loan Agreement, but only to the extent, in accordance with the terms,
subject to the conditions and in reliance upon the representations and warranties set forth below. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing recitals and other good and valuable consideration, the receipt and adequacy of which is hereby
acknowledged, and intending to be legally bound, the parties hereto agree as follows: 
 1. Definitions. Capitalized terms used but
not defined in this Amendment shall have the meanings given to them in the Loan Agreement. 
 2. Amendments to Loan Agreement.

 2.1 Section 2.4 (Interest Rate, Payments). Section 2.4(a) is amended in part to read as follows: 

(a) Interest Rate. Effective as of December 15, 2006, (i) Advances, Term Loan 2 and Equipment Advances accrue interest on the
outstanding principal balance at a per annum rate of 0.375% above the Prime Rate. 
 2.2 Section 2.4 (Interest Rate, Payments).
The first sentence under Section 2.4(b) is hereby amended in its entirety and replaced with the following: 
 (b) Payments. Interest due on the Committed Revolving Line is payable on the 24th of each month.

 2.3 Section 2.5 (Fees). Notwithstanding anything under Section 2.5(a), Borrower will pay to Bank an anniversary fee of
$7,500 on May 24, 2007. Bank is hereby authorized to debit Borrower’s account number                         
for the anniversary fee on May 24, 2007. 
 2.4 Section 6.2 (Financial Statements, Reports, Certificates).
Section 6.2(e) is hereby amended in its entirety and replaced with the following: 

 (e) Allow Bank to audit Borrower’s Collateral at Borrower’s expense. Such audits will be
conducted not more often than once a year unless an Event of Default has occurred and is continuing. 
 2.5 Section 6.6 (Primary
Accounts). Section 6.6 is amended in its entirety and replaced with the following: 
 Borrower will maintain all of its primary
operating and securities accounts at Bank or its affiliates. 
 2.6 Section 6.7 (Financial Covenants). Section 6.7(ii)
entitled “Tangible Net Worth” is hereby deleted in its entirety. 
 2.7 Section 13 (Definitions). Sub-letter
(e) of the defined term “Eligible Accounts” is hereby amended to include the following: 
 Notwithstanding the forgoing, if Borrower’s
Adjust Quick Ratio is equal to 2.50 to 1.00 or greater, Bank may include those accounts from account debtors does not have it principal place of business in the United States, provided, however, if the Adjusted Quick Ratio is less than 2:50 to 1:00,
then those accounts will be at Bank sole discretion. 
 2.8 Section 13. (Definitions). The following term and its respective
definition set forth in Section 13.1 is amended in its entirety and replaced with the following: 
 “Revolving Maturity
Date” is May 24, 2008. 
 3. Limitation of Amendments. 
 3.1 The amendments set forth in Section 2, above, are effective for the purposes set forth herein and shall be limited precisely as
written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the
future under or in connection with any Loan Document. 
 3.2 This Amendment shall be construed in connection with and as part of the
Loan Documents and all terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall remain in full force and effect. 
 4. Representations and Warranties. To induce Bank to enter into this Amendment, Borrower hereby represents and warrants to Bank as follows:

 4.1 Immediately after giving effect to this Amendment (a) the representations and warranties contained in the Loan Documents
are true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date, in which case they are true and correct as of such date), and (b) no Event of
Default has occurred and is continuing; 
 4.2 Borrower has the power and authority to execute and deliver this Amendment and to
perform its obligations under the Loan Agreement, as amended by this Amendment; 
 4.3 The organizational documents of Borrower
delivered to Bank on May 27, 2004 remain true, accurate and complete and have not been amended, supplemented or restated and are and continue to be in full force and effect; 
 4.4 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as
amended by this Amendment, have been duly authorized; 
 4.5 The execution and delivery by Borrower of this Amendment and the
performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower, (b) any contractual restriction with a Person
binding on Borrower, (c) any order, judgment or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower; 
 4.6 The execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as
amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental or public body or authority, or subdivision thereof, binding
on either Borrower, except as already has been obtained or made; and 

 4.7 This Amendment has been duly executed and delivered by Borrower and is the binding obligation
of Borrower, enforceable against Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other similar laws of general application and equitable
principles relating to or affecting creditors’ rights. 
 5. Integration. This Amendment and the Loan Documents represent the
entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Amendment and the
Loan Documents merge into this Amendment and the Loan Documents. 
 6. Counterparts. This Amendment may be executed in any number of
counterparts and all of such counterparts taken together shall be deemed to constitute one and the same instrument. 
 7.
Effectiveness. This Amendment shall be deemed effective upon the due execution and delivery to Bank of this Amendment by each party hereto. 
 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed and delivered as of the date first written above. 
  

									
	BANK	 		 	BORROWER
			
	Silicon Valley Bank	 		 	Pharsight Corporation
					
	By:	 	 /s/ Liam Fairbairn
	 		 	By:	 	 /s/ William Frederick

	Name:	 	Liam Fairbairn	 		 	Name:	 	William Frederick
	Title:	 	Relationship Manager	 		 	Title:	 	Chief Financial OfficerForm of Series A 3% Convertible Preferred Stock Certificate

 Exhibit 4.1 
  

					
	Number PA-            	  	CELL THERAPEUTICS, INC.	  	*                        *
Shares
		  	A Washington Corporation	  	Series A Preferred Stock

 THIS CERTIFIES THAT
*                        * is the record holder of
*                        *
(                        ) shares of Series A Preferred Stock of Cell Therapeutics, Inc. (the
“Corporation”) transferable only on the share register of the Corporation by the holder, in person or by such holder’s duly authorized attorney, upon surrender of this certificate properly endorsed or assigned. 
 This certificate and the shares represented hereby shall be held subject to all of the provisions of the Articles of Incorporation and the Bylaws of the
Corporation and any amendments thereto, a copy of each of which is on file at the office of the Corporation and made a part hereof as fully as though the provisions of said Articles of Incorporation and Bylaws were imprinted in full on this
Certificate, to all of which the holder of this Certificate, by acceptance hereof, assents and agrees to be bound. 
 The shares represented
by this Certificate are convertible into shares of Common Stock as set forth in the Articles of Incorporation of the Corporation and shall be so converted upon the occurrence of certain events as set forth in said Articles of Incorporation.

 The Corporation will furnish without charge to each shareholder who so requests, the powers, designations, preferences and relative,
participating, optional or other special rights of each class of stock or series thereof and the qualifications, limitations or restrictions of such preferences or rights. 
 IN WITNESS WHEREOF, the Corporation has caused this Certificate to be signed by its duly authorized officers this
            , 2007. 
  

					
	  
	 		 	  

	Donald W. Wyatt, Secretary	 		 	James A. Bianco, M.D., President and CEO

  

 FOR VALUE RECEIVED, THE UNDERSIGNED HEREBY SELLS, ASSIGNS AND TRANSFERS UNTO
                                        
                                        
SHARES REPRESENTED BY THE WITHIN CERTIFICATE AND DOES HEREBY IRREVOCABLY CONSTITUTE AND APPOINT
                                 ATTORNEY TO TRANSFER THE SAID SHARES ON THE SHARE
REGISTER OF THE WITHIN NAMED CORPORATION WITH FULL POWER OF SUBSTITUTION IN THE PREMISES. 
 DATED
                     
  

	
	  

	(Signature)

 NOTICE: THE SIGNATURE ON THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THIS
CERTIFICATE, IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT, OR ANY CHANGE WHATEVER.

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