Document:

exv10w20

 

Exhibit 10.20

TERMINATION AND SETTLEMENT AGREEMENT

     This Termination and Settlement Agreement is entered into this 7th day of October,
2004 (“Effective Date”) between Allergan Sales, LLC (“Allergan”) and Peplin Operations
Pty Ltd. (“Peplin”) and their guarantors, Allergan, Inc., and Peplin Ltd. (formerly,
Peplin Biotech Ltd.) (hereinafter referred to as “Agreement”).

RECITALS

     WHEREAS,
Peplin previously granted to Allergan a license to the Compound and Improvements in the Field in the Territory (as those terms are defined below), on
the
terms of a Collaboration and License Agreement between the Parties dated November
22,
2002 (“C&L Agreement”).

     WHEREAS,
ALLERGAN previously desired to amend, and Peplin previously
agreed to the amendment of, the C&L Agreement on the terms of the First Amendment to
Collaboration and License Agreement dated May 26, 2004
(“Amendment Agreement”).

     WHEREAS the Parties wish to terminate the C&L Agreement, as amended by the Amendment
Agreement, on the terms of this Agreement.

     NOW THEREFORE, the Parties agree as follows:

1. For purposes of this Agreement, the following terms shall have the meanings
specified below:

“Affiliate”
means, in the case of either Party, a corporation or other entity
which, directly or indirectly, controls, is controlled by or is under common
control with, that Party. A corporation or other entity shall be regarded as in
control of another corporation or entity if it owns or directly or indirectly
controls 50% (fifty percent) or more of the voting stock or other ownership
interest of the other corporation or entity, or if it possesses, directly or
indirectly, the power to direct or cause the direction of the management and policies of the
corporation or other entity.

“Compound” means PEP005, and any other compounds deemed to be a
Compound in accordance with the terms of the C&L Agreement.

“Confidential Information” means all information, inventions, trade secrets,
know-how, and data, whether or not in a material form, relating to this Agreement
and/or the subject matter of this Agreement disclosed by one Party to the other
Party.

“Control” means the ability, whether by ownership or license, to grant a license
or sublicense as provided for herein without violating the terms of any agreement
or other right of any Third Party.

“FDA” means the U.S. Food and Drug Administration or any successor entity thereto.

Page 1 of 12

 

 

“Field” means (i) Topical Applications of the Compound or Improvements for any Skin and
Eye Conditions; and (ii) Intralesional Applications of the Compound for Skin and Eye
Conditions made solely through direct sales to dermatologists and plastic surgeons, and
such other physicians as may be mutually agreed by the Parties in writing from time to
time.

“Improvement” means a compound which is an Ingenane Compound or substituted Ingenane
Compound and which has potential use in the Field or any new formulation or
isomer thereof.

“IND” means an Investigational New Drug application as defined in the U.S. Food, Drug and
Cosmetic Act, as it may be amended from time to time, and the regulations promulgated
thereunder, or as the context requires, any corresponding application in a country other
than the USA.

“Ingenane Compound” means any compound containing the ingenol skeleton, “ingenol” being
the compound having the chemical name 1 a, 2,5,5a,6,9, 10,10a, Octahydro-5, 5a,
6-trihydroxy4 (hydroxymethyl) 1,1,7,9, tetramethyl 1 H-2, 8
amethanocyclopenta[a]clopropa[e] cyclodecen-11 one, and the empirical formula
C20H28O5.

“Intellectual
Property Rights” means all copyright trade mark, design, patent
(including, without limitation, the Peplin Patent Rights), semi-conductor and/or circuit
layout rights; trade, business, company and/or domain names; any right to have
confidential information kept confidential (including, without limitation, the Peplin
Know-How); other proprietary rights; and/or any rights to registration of such rights
existing anywhere in the world, whether created before, on or after the date of this
Agreement relating to the Compound, an Improvement (irrespective of whether it has
potential use in the Field), the Product and/or any Oral Formulation, including, without
limitation, any potential uses thereof.

“Intralesional Application” means the treatment of a lesion by direct injection of the
Compound into the lesion.

“Oral Formulation” means a formulation of the Compound or Improvement that is delivered
by the mouth and absorbed systemically by the gut.

“Party”  means Peplin or Allergan and/or their respective Affiliates as the context requires and
“Parties” means, collectively, Peplin and Allergan and/or their respective Affiliates.

“Patent Rights” means issued patents and pending patent applications (whether provisional or
otherwise) in the United States of America or any countries in the Territory that cover the
manufacture, use, sale, offer for sale and/or importation of the Compound and/or Improvements
in the Field, and any applications and/or patents claiming priority to said patents or
applications, including all divisions, continuations, reissues, reexaminations, continuations
in part, continued prosecution applications (“CPA”), requests for continued examination
(“RCE”), extensions and substitutions thereof, and any applications filed under the Patent
Cooperation Treaty. A current list of Patent Rights, as at the date of the C&L Agreement, is
attached as Exhibit A to the C&L Agreement.

Page 2 of 12

 

 

“PEP005” means the compound originally isolated from the Euphorbia peplos plant, and
having the chemical name angeloyl 3-ingenol or ingenol 3-angelate and the empirical
formula
C25H34O6, current specifications for which are attached as Exhibit B to the C&L
Agreement.

“Peplin Know-How” means proprietary techniques and data within the Field, including
inventions, practices, methods, knowledge, know-how, assays, compositions of matter,
test data (including pharmacological, toxicological and clinical test data), analytical
and quality control data, manufacturing data and descriptions, which (i) Peplin
discloses to Allergan under this Agreement and (ii) is within the Control of Peplin.
Notwithstanding anything herein to the contrary, Peplin Know-How shall exclude Peplin
Patent Rights.

“Peplin
Patent Rights” means the Patent Rights Controlled by
Peplin.

“Phase
IA Clinical Trials” means the clinical trial the subject of IND 70114 for
the use of topical PEP005 for the treatment of actinic keratosis filed by Allergan
in June 2004.

“Product”
means pharmaceutical formulations containing the Compound or an
Improvement.

“Regulatory Approval” means any approval, license, registration or authorization of any
supra-national, federal, state or local regulatory agency or government authority
necessary for the manufacture, use, storage, import, export, transport or sale of a
Product in a regulatory jurisdiction, including where applicable, pricing approval.

“Regulatory
Filings” includes, without limitation, IND’s, Regulatory Approvals and/or all
documents relating, either directly or indirectly, thereto;

“Skin and Eye Conditions”
means diseases or conditions of the human skin
including epidermis and dermis, and diseases or conditions of the human eye,
respectively.

“Territory” means the United States of America, Canada, Mexico, Central America and South America,
including the countries of Antigua and Barbuda, the Bahamas, Barbados, Belize, Costa Rica, Cuba,
Dominica, Dominican Republic, El Salvador, Greenland, Grenada, Guatemala, Haiti, Honduras, Iceland,
Jamaica, Nicaragua, Panama, Saint Kitts and Nevis, Saint Lucia, Saint Vincent and the Grenadines,
Trinidad and Tobago, Bolivia, Brazil, Chile, Columbia, Ecuador, French Guiana, Guyana, Paraguay,
Peru, Suriname, Uruguay, and Venezuela.

“Third Party” means any entity other than Peplin and Allergan.

“Topical Application” means the treatment of disease by delivery in a topical
dosage form to the outer surface of the diseased area for dermatologic and
ophthalmic administration.

     2. Notwithstanding anything to the contrary in Section 11 of the C&L Agreement,
subject to the terms of this Agreement, the Parties agree to terminate the C&L Agreement, as
amended by the Amendment Agreement, as and from the Effective

Page 3 of 12

 

 

Date, except for Section 8 of the C&L Agreement and/or any non-expired nondisclosure
agreement entered into between the Parties, which shall survive termination of the C&L
Agreement.

     3. Allergan agrees to pay to Peplin One Million Two Hundred and Eighty Nine Thousand Six
Hundred and Fifty Seven U.S. Dollars (U.S. $1,289,657) on the Effective Date in full payment
of all monies due to Peplin under the C&L Agreement. Such payment shall be nonrefundable and
noncreditable.

     4. Allergan will, consistent with accepted and efficient business practices and legal
requirements relating to pharmaceutical drug development, complete, as soon as practicable but
not more than ninety (90) days from the Effective Date, monitoring at Allergan’s expense and
promptly providing Peplin or its designee as it becomes available with the case report
forms, any adverse event reports and all other relevant data and information (including,
without limitation, randomization codes) concerning the Phase IA Clinical Trials for the
Product. Allergan will provide, if practicable, prototype database forms relevant to the
study, and will provide reasonable non-monetary assistance to Peplin in its discussions of the
Phase IA Clinical Trials for the Product with the FDA, including, without limitation,
attendance at FDA meetings. Reasonable travel costs incurred by Allergan in attending such
meetings will be met by Peplin.

     5. Notwithstanding Sections 2.7 and 7.1 of the C&L Agreement, Peplin shall
have all right, title and interest (including all Intellectual Property Rights) in and to
all of
the Parties’ respective inventions, discoveries, methods and/or processes conceived or
reduced to practice by Peplin, Allergan and/or the Parties jointly and all associated
Regulatory Filings arising out of, either directly or indirectly, the C&L Agreement (as
amended by the Amendment Agreement) and/or this Agreement relating to the
Compound, any Improvement (irrespective of whether it has potential use in the Field),
the Product and/or any Oral Formulation, including, without limitation, any potential
uses
thereof.

     6. Subject to Allergan’s statutory requirements for record keeping (where records are required
to be maintained, copies are to be provided to Peplin) and to the extent Allergan has information
or materials available (providing Allergan uses its reasonable endeavours to locate such
information and/or materials), and without limiting Section 8.6 of the C&L Agreement, which shall
survive termination of the C&L Agreement under Section 2 of this Agreement, Allergan must deliver
up to Peplin all Compounds, Improvements (irrespective of whether it has potential use in the
Field), Products and Oral Formulations and all associated Regulatory Filings arising out of, either
directly or indirectly, the C&L Agreement (as amended by the Amendment Agreement) and/or this
Agreement in its possession or under its control on or before the Effective Date. Without limiting
the generality of the foregoing, Allergan agrees to transfer the current IND’s for PEP005 to Peplin
or its designee, to hand over to Peplin all original hard copies of reports and copies of documents
stored on its information management system (including validation reports), original certificates
of analysis and batch records, to transfer to Peplin or its designee all of Allergan’s data and
information

Page 4 of 12

 

 

regarding its planned Phase I-B Study in Australia (including any applications to the
Therapeutic Goods Administration or institutional ethics committees), to provide to Peplin or
its designee any PEP005 (AGN 204332) it may have both formulated and active pharmaceutical
ingredient and, if Product has been destroyed prior to the Effective Date, to provide to
Peplin or its designee the corresponding certificates of destruction on or before the
Effective Date.

     7. Subject always to Peplin’s rights to exploit the rights vested in it under
Section 5 of this Agreement, the Parties agree that a Party receiving any Confidential
Information (“Receiving Party”) of the other Party
(“Disclosing Party”) shall (a) maintain
in confidence such Confidential Information to the same degree of care such Party
maintains its own valuable confidential information, but not less
than a reasonable degree of care; (b) not disclose such Confidential Information to anyone other than regulatory
authorities in the course of seeking Regulatory Approvals and any of the Receiving
Party’s employees or consultants or contractors or Third Parties involved in the
development, manufacture and/or distribution of the Product who need to know such
Confidential Information to permit such Receiving Party to practice its rights under this
Agreement and who have agreed to substantially similar obligations concerning such
Confidential Information as those set forth herein, or as otherwise required by law; (c)
not use such Confidential Information for any purpose except those expressly permitted by this
Agreement; and (d) take reasonable steps to prevent unauthorized use or disclosure of such
Confidential Information.

     8. Subject always to Peplin’s rights to exploit the rights vested in it under
Section 5 of this Agreement, in the event either Party is requested or is required by
deposition, interrogatories, requests for information, documents or admissions,
subpoenas, civil investigative demands or similar process, to disclose or provide any
Confidential Information, the Parties shall promptly meet to discuss how best to respond
and, for example, whether to seek an appropriate protective order or confidential
treatment or otherwise prevent such disclosure.

     9. Subject always to Peplin’s rights to exploit the rights vested in it under
Section 5 of this Agreement, obligations under this Agreement with respect to
Confidential Information shall only cease where such information can
be shown by written evidence that it: (a) has become generally known in the pharmaceutical industry or by the public
at large at the time of or after disclosure by the Disclosing Party,
other than through breach of
this Agreement by the Receiving Party; (b) was in the possession of the Receiving Party, without
any obligation of confidentiality, immediately prior to the time of disclosure by the Disclosing
Party, and the Receiving Party did not come to be in such possession through disclosure from the
Disclosing Party or any of the Disclosing Party’s Affiliates or sublicensees; or (c) was
independently developed by employees or agents of the Receiving Party without knowledge of, access
to, or use of any Confidential Information of the Disclosing Party.

Page 5 of 12

 

 

     10. Subject always to Peplin’s rights to exploit the rights vested in it under
Section 5 of this Agreement, in the event of termination of this
Agreement, at any time
thereafter upon the request of the Disclosing Party, the Receiving Party shall promptly return
to the Disclosing Party or destroy (at the Disclosing Party’s option) the Disclosing Party’s
Confidential Information responsive to such request, including all copies thereof and in
whatever form, except that the Receiving Party may retain one copy of the Confidential
Information to be used solely to determine the scope of the Receiving
Party’s obligations under
this Agreement. The return and/or destruction of such Confidential Information as provided
above shall not relieve the Receiving Party of its other obligations under this Agreement.

     11. The Parties agree to issue press releases concerning the termination of the C&L
Agreement, attached hereto as Exhibit A.

     12. Allergan agrees to provide reasonable non-monetary assistance to Peplin in its
re-licensing efforts, including, without limitation, identifying potential candidates and
providing contact information and introductions.

     13. Peplin agrees to provide Allergan with a three (3) month non-exclusive right of
negotiation for future rights in PEP005, if Peplin has not licensed PEP005 to a Third
Party by January 1, 2006. If no license has been executed within the three (3) month
period, the right of negotiation will expire.

     14. Peplin agrees to pay to Allergan the following:

	 	A.	 	twenty-five percent (25%) of all pre-commercialisation payments in the nature of up
front, milestone, full time equivalent or similar payments but excluding reimbursements of
costs, contributions to help defray the costs of specific works, sales taxes, VAT taxes
and other taxes) received by Peplin or a Peplin Affiliate in exchange for licensing or
other transfer of rights in the Topical Application of PEP005 for any Skin and Eye
Condition up to a maximum amount of Three Million U.S. Dollars ($3,000,000); and
	 
	 	B.	 	twenty-five percent (25%) of all post-commercialisation payments in the nature of
royalties, sales milestone payments and the like (but excluding reimbursements of costs,
contributions to help defray the costs of specific works, sales taxes, VAT taxes and other
taxes) received by Peplin or a Peplin Affiliate in exchange for licensing or other
transfer of rights in the Topical Application of PEP005 for any Skin and Eye Condition in
the Territory (royalties shall be deemed to include that portion of transfer price of
materials provided by Peplin that exceeds Peplin’s costs for such materials) up to a
maximum amount, which amount shall include any amounts paid under Section 15 (A) of this
Agreement, of Four Million U.S. Dollars ($4,000,000); and

Page 6 of 12

 

	 	C.	 	ten percent (10%) of net sales of Product made by Peplin or an Affiliate of Peplin for
the Topical Application of PEP005 for any Skin and Eye Condition in the Territory up to a
maximum amount, which amount shall include any amounts paid under Section 15(A) and/or
15(B) of this Agreement, of Four Million U.S. Dollars ($4,000,000); and
	 
	 	D.	 	Total payments to Allergan under Sections 15 (A) to 15(C), inclusive, of this
Agreement shall not exceed, in the aggregate, Four Million U.S. Dollars ($4,000,000).

	15. 	A.	 	Each of the Parties acknowledges that the other Party has carried out
all of the terms and conditions of the C&L Agreement and that neither Party is in breach
of the C&L Agreement.
	 
	 	B.	 	Allergan and its Affiliates for themselves and their agents, successors
and assigns, do hereby forever release and discharge Peplin, its Affiliates and any
of their past or present agents, employees, officers, directors, attorneys and
supplies from any causes of action, losses, damages, costs, expenses, liabilities
and/or demands of whatsoever character, nature and kind, known or unknown,
suspected or unsuspected, fixed or contingent, arising out of or in any way related
to the C&L Agreement.
	 
	 	C.	 	Peplin and its Affiliates for themselves and their agents, successors
and assigns, do hereby forever release and discharge Allergan, its Affiliates and
any of their past or present agents, employees,  officers, directors, attorneys
and supplies from any causes of action, losses, damages, costs, expenses,
liabilities and/or demands of whatsoever character, nature and kind, known or
unknown suspected or unsuspected, fixed or contingent, arising out of or in any way
related to the C&L Agreement.
	 
	 	D.	 	Waiver of Section 1542 of the California Civil Code and Similar Statues. The
Parties specifically understand, acknowledge and agree that this is a full and final release,
which shall be effective as a bar to all actions, claims, counterclaims, obligations, causes
of action, losses, damages, costs, expenses, liabilities and demands of whatsoever character,
nature and kind, known or unknown, suspected and unsuspected, fixed and contingent,
hereinabove specified to be so barred. The Parties having been fully advised by their
respective counsel, hereby expressly and voluntarily waive all rights or benefits that they
and each of them might otherwise have under the provisions of §1542 of the Civil Code of the
State of California, and under all federal, sate and/or common law statutes

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	 	 	 	or principles of similar effect. The parties recognize that §1542 of
the Civil Code of the State of California reads as follows:
	 
	 	 	 	“A general release does not extend to claims which the creditor does
not know or suspect to exist in his favor at the time of executing the
release, which if known by him must have materially affected his
settlement with the debtor.”

     16. Miscellaneous.

     16.1 Assignment. This Agreement may not be assigned or otherwise transferred
by either Party without the prior written consent of the other Party, which consent shall not
be unreasonably withheld or delayed; provided, however, that each of the Parties may, without
such consent, assign this Agreement and its rights and obligations hereunder to its
Affiliates or in connection with the transfer or sale of all or substantially all of its
business, or in the event of its merger or consolidation or change in control or similar
transaction (which shall be deemed an assignment). Notwithstanding the foregoing, Allergan
can sell, transfer or assign its rights under this Agreement to any Third Party as part of a
sale of substantially all of its assets related to its dermatology business. Any purported
assignment in violation of the preceding sentences shall be void. Any permitted assignee
shall assume all obligations of its assignor under this Agreement in writing.

     16.2 Severability. Each Party hereby agrees that it does not intend to violate any
public policy, statutory or common laws, rules, regulations, treaty or decision of any government
agency or executive body thereof of any country or community or associate of countries. Should one
or more provisions of this Agreement be or become invalid, the Parties hereto shall substitute, by
mutual consent, valid provisions for such invalid  provisions which valid provisions in their
economic effect are sufficiently similar to the invalid provisions that it can be reasonably
assumed that the Parties would have entered into this Agreement with such valid provisions. In case
such valid provisions cannot be agreed upon, the invalidity of one or several provisions of this
Agreement shall not affect the validity of this Agreement as a whole, unless the invalid provisions
are of such essential importance to this Agreement that it is to be reasonably assumed that the
Parties would not have entered into this Agreement without the invalid provisions. Allergan and
Peplin acknowledge and agree that each provision of this Agreement is material to their respective
decisions to enter into this Agreement. Allergan and Peplin further acknowledge and agree that
neither of them would have entered into this Agreement in the absence of any of its provisions.

     16.3 Notices. Any consent, notice or report required or permitted to be given or
made under this Agreement by one of the Parties hereto to the other
shall be in writing,
delivered personally or by facsimile (and promptly confirmed by personal delivery or
courier) or international courier, addressed to such other Party at its address indicated
below, or to such other address as the addressee shall have last furnished in writing to the

Page 8 of 12

 

addressor and shall be effective upon the earlier of receipt by the addressee or the
second business day after dispatch by recognized international courier.

	 	 	 	 	 
	If to Peplin:

	 	Peplin Operations Pty Ltd.
	 	 
	 

	 	Level 2	 	 
	 

	 	1 Breakfast Creek Road	 	 
	 

	 	Newstead, Brisbane	 	 
	 

	 	Australia	 	 
	 

	 	Attention: Company Secretary	 	 
	 

	 	Tel: 61 7 3250 1200	 	 
	 

	 	Fax: 61 7 3250 1299	 	 
	 
	 	 	 	 
	With a copy to:

	 	Peplin Ltd.	 	 
	 

	 	Level 2	 	 
	 

	 	1 Breakfast Creek Road	 	 
	 

	 	Newstead, Brisbane	 	 
	 

	 	Australia	 	 
	 

	 	Attention: Managing Director	 	 
	 

	 	Tel: 61 7 3250 1200	 	 
	 

	 	Fax: 61 7 3250 1299	 	 
	 
	 	 	 	 
	If to Allergan:

	 	Allergan, Inc.	 	 
	 

	 	2525 Dupont Drive	 	 
	 

	 	Irvine, California 92612	 	 
	 

	 	Attention: Corporate VP Business Development	 	 
	 

	 	Tel: (714) 246-6837	 	 
	 

	 	Fax: (714) 246-2228	 	 
	 
	 	 	 	 
	With a copy to:

	 	Allergan, Inc.	 	 
	 

	 	2525 Dupont Drive	 	 
	 

	 	Irvine, California 92612	 	 
	 

	 	Attention: General Counsel	 	 
	 

	 	Tel: (714) 246-4535	 	 
	 

	 	Fax: (714) 246-6987	 	 

     16.4 Applicable Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of California, United States, without reference to its
conflict of laws, rules and in connection with any dispute hereunder, subject to Section 16.5
below, the Parties consent to exclusive jurisdiction and venue in the state and federal courts in
Orange County, California, United States.

     16.5 Dispute Resolution. Except with respect to matters pertaining to
injunctive relief, in the event of any dispute, the Parties shall refer such dispute to the
Chief Executive Officers of Peplin and Allergan (or their respective executive officer

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level designees) for attempted resolution by good faith negotiations within thirty (30) days
after such referral is made. During such period of good faith negotiations, any applicable time
periods under this Agreement shall be suspended. In the event such executives are unable to resolve
such dispute within such thirty (30) day period, the parties shall submit this dispute to binding
arbitration before a single arbitrator in Orange County, California, such arbitration to be
conducted pursuant to the American Arbitration Association rules for commercial disputes then in
effect. The arbitrator may permit limited discovery as he or she deems appropriate in the
circumstances of the dispute. The arbitrator shall have no power to include an award of attorneys’
fees and costs to the prevailing party, or to award punitive,
special, incidental or consequential damages.

     16.6 Entire Agreement. This Agreement contains the entire understanding of
the Parties with respect to the subject matter hereof. All express or implied agreements
and understandings, either oral or written, heretofore made are expressly merged in and
made a part of this Agreement. This Agreement may be amended, or in any term hereof
modified, only by a written instrument duly executed by both Parties hereto.

     16.7 No license or right is hereby granted by implication or otherwise, with
respect to any Intellectual Property Rights and the Parties hereby agree that under no
circumstances may a court find or hold the existence of any such implied license.

     16.8 Each Party must do all things and execute all further documents necessary
to give full effect to this Agreement and refrain from doing anything that might hinder
the performance of this Agreement.

Page 10 of 12

 

     IN WITNESS WHEREOF, the Parties have by their duly authorized
representatives hereunto set their hands the day and year first above written.

	 	 	 	 	 	 	 	 	 	 	 
	ALLERGAN SALES, LLC	 	 	 	PEPLIN OPERATIONS PTY LTD.	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Jeffrey L. Edwards
 

	 	 
	 	By:
	 	/s/ Michael Aldridge
 

	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name: Jeffrey L. Edwards	 	 	 	Name: Michael Aldridge	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Title: Vice President	 	 	 	Title: Director	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Date: October 7, 2004	 	 	 	Date: 7 October 2004	 	 

AGREED TO:

	 	 	 	 	 	 	 	 	 	 	 
	ALLERGAN, INC.	 	 	 	PEPLIN LTD.	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Jeffrey L. Edwards
 

	 	 
	 	By:
	 	/s/ Michael Aldridge
 

	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name: Jeffrey L. Edwards	 	 	 	Name: Michael Aldridge	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Title: Vice President	 	 	 	Title: Managing
Director & CEO	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Date: October 7, 2004	 	 	 	Date: 7 October, 2004	 	 

Page 11 of 12exv10w21

 

Exhibit 10.21

August 8, 2007

Peplin Limited

[SUBSCRIBER]

Subscription

 Agreement

 

 

Contents

	 	 	 	 	 
	1   Definitions and Interpretation
	 	 	1	 
	 
	 	 	 	 
	1.1 Definitions
	 	 	1	 
	1.2 Construction
	 	 	3	 
	1.3 Headings
	 	 	4	 
	 
	 	 	 	 
	2   Subscription
	 	 	5	 
	 
	 	 	 	 
	2.1 Obligation to subscribe
	 	 	5	 
	2.2 Terms of issue
	 	 	5	 
	 
	 	 	 	 
	3   Completion
	 	 	5	 
	 
	 	 	 	 
	3.1 Place and time
	 	 	5	 
	3.2 Obligations of Subscriber
	 	 	5	 
	3.3 Obligations of Company
	 	 	5	 
	3.4 Interdependence of obligations
	 	 	5	 
	 
	 	 	 	 
	4   Period after Completion
	 	 	6	 
	 
	 	 	 	 
	5   Confidentiality
	 	 	6	 
	 
	 	 	 	 
	5.1 Basis for providing Confidential Information
	 	 	6	 
	5.2 Maintenance of confidentiality and use of Confidential Information
	 	 	6	 
	5.3 Information that is not Confidential Information
	 	 	6	 
	5.4 Permitted disclosures
	 	 	7	 
	5.5 Public Disclosures
	 	 	7	 
	 
	 	 	 	 
	6   Standstill
	 	 	7	 
	 
	 	 	 	 
	6.1 Sale and purchase of Shares
	 	 	7	 
	6.2 Exceptions
	 	 	7	 
	6.3 Disposal of Securities
	 	 	7	 
	 
	 	 	 	 
	7   Insider Trading
	 	 	7	 
	 
	 	 	 	 
	8   Warranties
	 	 	8	 
	 
	 	 	 	 
	8.1 Mutual warranties
	 	 	8	 
	8.2 Additional warranties by the Subscriber
	 	 	8	 
	8.3 Subscriber Covenants
	 	 	9	 
	8.4 Additional warranty by the Company
	 	 	9	 
	 
	 	 	 	 
	9   Consent to be Named
	 	 	10	 
	 
	 	 	 	 
	10   Notices
	 	 	10	 
	 
	 	 	 	 
	10.1 General
	 	 	10	 
	10.2 How to give a communication
	 	 	10	 
	10.3 Communications by post
	 	 	10	 
	10.4 Communications by fax
	 	 	10	 
	10.5 After hours communications
	 	 	10	 
	10.6 Process service
	 	 	10	 
	 
	 	 	 	 
	11   GST
	 	 	11	 
	 
	 	 	 	 
	11.1 Interpretation
	 	 	11	 

Page i

 

	 	 	 	 	 
	11.2 GST gross up
	 	 	11	 
	11.3 Reimbursements
	 	 	11	 
	11.4 Tax invoice
	 	 	11	 
	11.5 Adjustment events
	 	 	11	 
	 
	 	 	 	 
	12   General
	 	 	11	 
	 
	 	 	 	 
	12.1 Duty
	 	 	11	 
	12.2 Legal costs and other expenses
	 	 	11	 
	12.3 Amendment
	 	 	11	 
	12.4 Waiver and exercise of rights
	 	 	12	 
	12.5 Rights cumulative
	 	 	12	 
	12.6 Further steps
	 	 	12	 
	12.7 Governing law and jurisdiction
	 	 	12	 
	12.8 Assignment
	 	 	12	 
	12.9 Counterparts
	 	 	12	 
	12.10 Entire understanding
	 	 	12	 
	 
	 	 	 	 
	Schedule 1 -
	 	 	14	 

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	 	 	Date
	 
	 	 	Parties
	 
	 	 	Peplin Limited ACN 090 819 275 of Level 2, Brisbane Portal, 1 Breakfast Creek
Road, Newstead, Queensland (Company)
	 
	 	 	[SUBSCRIBER] [ADDRESS] (Subscriber)
	 
	 	 	Background

	A	 	The Company is seeking to raise an aggregate amount of
approximately A$20 million by way of a placement to institutional
investors.
	 
	B	 	The Subscriber wishes to subscribe for the Subscription Shares
and the Company agrees to issue and allot the Subscription Shares
to the Subscriber on the terms set out in this document.
	 
	C	 	The Company and the Subscriber have agreed to exchange
Confidential Information for the purposes of the Placement on the
terms set out in this document.
	 
	 	 	Agreed terms

	 
	1	 	Definitions and
Interpretation
	 
	1.1	 	Definitions
	 
	 	 	The following definitions apply (including in the Recitals) unless the context
requires otherwise.
	 
	 	 	Adviser means, in relation to a party, its legal, financial or other expert advisers or
agents.
	 
	 	 	ASIC means the Australian Securities and Investments Commission.
	 
	 	 	Associate has the meaning given in sections 10 to 17 of the Corporations Act.
	 
	 	 	ASX means ASX Limited ACN 008 624 691.
	 
	 	 	ASX Listing Rules means the official rules of ASX as amended from time to time.
	 
	 	 	ASTC Settlement Rules means the settlement rules of the ASX Settlement and Transfer
Corporation Pty Ltd.

Page 1

 

	 	 	Business Day means a day which is not a Saturday, Sunday or bank or public holiday in
Sydney, New South Wales.
	 
	 	 	Completion means the issue and allotment of the Subscription Shares in accordance with
clause 3.
	 
	 	 	Completion Date means the date on which Completion takes place, being within 5 Business
Days of the earlier of:

	 	(a)	 	the dispatch of the Information Memorandum to shareholders and
optionholders of the Company; or
	 
	 	(b)	 	the termination of the Restructure Implementation Agreement.

	 	 	Confidential Information means:

	 	(a)	 	all information, whether written, oral, electronic or in any other form
provided (before or after the date of this document) by any party or its
Representatives relating to that party’s operations, affairs and/or business
including without limitation know how, trade secrets, intellectual property rights,
business, corporate or trade information;
	 
	 	(b)	 	all analyses, compilations, forecasts, studies or other documents
prepared by any party which contain or reflect any such information;
	 
	 	(c)	 	the existence and content of this document; and
	 
	 	(d)	 	the existence of the Placement and other potential transactions relating
to the operations, affairs and business of a party to this document or a
Representative of a party to this document.

	 	 	Constitution means the constitution of the Company.
	 
	 	 	Corporations Act means the Australian Corporations Act 2001 (Cth).
	 
	 	 	Encumbrance means any mortgage, charge (whether fixed or floating), pledge,
hypothecation, option, conditional sale agreement, trust arrangement, restriction as to
transfer, or other form of security or equity interest.
	 
	 	 	Immediately Available Funds means cash or bank cheque or any other form of payment that
the parties agree in writing.
	 
	 	 	Information Memorandum means the explanatory statement to be dispatched to shareholders
and optionholders of the Company detailing the proposed schemes of arrangement and
capital raising as contemplated by the Restructure Implementation Agreement.
	 
	 	 	Material Non Public Information means any information which is not widely known by
participants in a relevant market and which could reasonably be expected to have a
material effect on the price or value of securities that trade in that market.
	 
	 	 	Officer means, in relation to an entity, its directors, officers and employees.
	 
	 	 	Placement means the subscription for the Subscription Shares by the Subscriber, and the
issue of the Subscription Shares to the Subscriber by the Company.

Page 2

 

	 	 	Representative in relation to a party means:

	 	(a)	 	each of the party’s related bodies corporate; and
	 
	 	(b)	 	the party’s or any of its related bodies corporate’:

	 	(i)	 	Officers; and
	 
	 	(ii)	 	Advisers.

	 	 	Restructure Implementation Agreement means the agreement entitled “Restructure
Implementation Agreement” dated on or about the date of this document between the Company
and Peplin, Inc.
	 
	 	 	Securities means:

	 	(a)	 	any Shares; or
	 
	 	(b)	 	any securities which:

	 	(i)	 	are convertible into; or
	 
	 	(ii)	 	give any right to receive; or
	 
	 	(iii)	 	relate to,

	 	 	 	Shares in the capital of the Company; or

	 	(c)	 	any legal, equitable or economic interest in those Shares or securities.

	 	 	Securities Act means the United States Securities Act of 1933, as amended.
	 
	 	 	Securities Laws means any law or rule which applies to a party or any of its
Representatives which prohibits any person who has Material Non Public Information about
an entity, obtained directly or indirectly from that entity, from purchasing or selling
securities of that entity or from communicating that information to any other person
(including the Corporations Act and the ASX Listing Rules).
	 
	 	 	Share means a fully paid ordinary share in the capital of the Company.
	 
	 	 	Standstill Period means the period commencing on the date of this document and ending
upon the earlier of the dispatch of the Information Memorandum to shareholders and
optionholders of the Company or the termination of the Restructure Implementation
Agreement.
	 
	 	 	Subscription Price means the amount set out in Part 2 of Schedule 1.
	 
	 	 	Subscription Shares means the Shares set out in Part 1 of Schedule 1.
	 
	1.2	 	Construction
	 
	 	 	Unless expressed to the contrary, in this document:

	 	(a)	 	words in the singular include the plural and vice versa;
	 
	 	(b)	 	any gender includes the other genders;
	 
	 	(c)	 	if a word or phrase is defined its other grammatical forms have
corresponding meanings;
	 
	 	(d)	 	“includes” means includes without limitation;

Page 3

 

	 	(e)	 	no rule of construction will apply to a clause to the disadvantage of a
party merely because that party put forward the clause or would otherwise benefit
from it;
	 
	 	(f)	 	a reference to:

	 	(i)	 	a person includes a partnership, joint venture,
unincorporated association, corporation and a government or statutory body or
authority;
	 
	 	(ii)	 	a person includes the person’s legal personal
representatives, successors, permitted assigns and persons substituted by
permitted novation;
	 
	 	(iii)	 	any legislation includes subordinate legislation under it
and includes that legislation and subordinate legislation as modified or
replaced;
	 
	 	(iv)	 	an obligation includes a warranty or representation and a
reference to a failure to comply with an obligation includes a breach of
warranty or representation;
	 
	 	(v)	 	a right includes a benefit, remedy, discretion or power;
	 
	 	(vi)	 	time is to local time in Brisbane;
	 
	 	(vii)	 	“$” or “dollars” is a reference to Australian currency;
	 
	 	(viii)	 	this or any other document includes the document as novated, varied or
replaced by agreement between the parties and despite any change in the
identity of the parties;
	 
	 	(ix)	 	writing includes any mode of representing or reproducing
words in tangible and permanently visible form, and includes fax
transmissions;
	 
	 	(x)	 	this document includes all schedules and annexures to it;
and
	 
	 	(xi)	 	a clause, schedule or annexure is a reference to a clause,
schedule or annexure, as the case may be, of this document;

	 	(g)	 	if the date on or by which any act must be done under this document is
not a Business Day, the act must be done on or by the next Business Day;
	 
	 	(h)	 	where time is to be calculated by reference to a day or event, that day
or the day of that event is excluded; and
	 
	 	(i)	 	a reference to any statement, including a warranty made by a party on the
basis of its knowledge, belief or awareness, is made on the basis of the actual
knowledge, belief or awareness of the officers of the party (and no other persons)
as at the date of this document.

	1.3	 	Headings
	 
	 	 	Headings do not affect the interpretation of this document.

Page 4

 

	2	 	Subscription
	 
	2.1	 	Obligation to subscribe
	 
	 	 	Subject to the provisions of this document:

	 	(a)	 	the Subscriber subscribes for the Subscription Shares at the Subscription
Price; and
	 
	 	(b)	 	the Company will allot and issue the Subscription Shares to the
Subscriber on the Completion Date.

	2.2	 	Terms of issue
	 
	 	 	On issue of the Subscription Shares, the Subscriber will be bound by the
provisions of the Constitution.
	 
	3	 	Completion
	 
	3.1	 	Place and time
	 
	 	 	Completion of the issue and allotment of the Subscription Shares to the Subscriber
by the Company will take place on the Completion Date at the offices of the Company, or
at any other time, date and place agreed in writing between the parties.
	 
	3.2	 	Obligations of Subscriber
	 
	 	 	On the Completion Date, the Subscriber will pay to the Company the total
Subscription Price for the Subscription Shares in Immediately Available Funds.
	 
	3.3	 	Obligations of Company
	 
	 	 	On the Completion Date, the Company will:

	 	(a)	 	allot the Subscription Shares to the Subscriber;
	 
	 	(b)	 	enter the Subscriber in the share register of the Company;
	 
	 	(c)	 	deliver a holding statement for the Subscription Shares to the Subscriber
issued in accordance with the ASTC Settlement Rules;
	 
	 	(d)	 	apply for official quotation of the Subscription Shares by lodging in
accordance with the ASX Listing Rules a completed appendix 3B in relation to the
Subscription Shares; and
	 
	 	(e)	 	provide ASX with a notice that complies with sections 708A(5)(e) and
708A(6) of the Corporations Act in relation to the Subscription Shares.

	3.4	 	Interdependence of obligations
	 
	 	 	The obligations of the parties under this clause 4 are interdependent. All acts
on the Completion Date must be treated as done simultaneously and no payment, delivery or
other act may be treated as made or done until all such deliveries, payments or acts are
made or done.

Page 5

 

	4	 	Period after Completion
	 
	 	 	The Company undertakes to use its best endeavours to obtain official quotation of
the Subscription Shares on ASX.
	 
	5	 	Confidentiality
	 
	5.1	 	Basis for providing Confidential Information
	 
	 	 	Each party will disclose Confidential Information to the other party to permit the
negotiation and completion of the Placement on the terms of this document.
	 
	5.2	 	Maintenance of confidentiality and use of Confidential Information
	 
	 	 	Each party agrees that:

	 	(a)	 	it will not disclose the other party’s Confidential Information to any
person or make use of or take advantage of the other party’s Confidential
Information for any purpose other than as expressly permitted by this document;
	 
	 	(b)	 	it will take all steps necessary to ensure that the other party’s
Confidential Information is kept confidential;
	 
	 	(c)	 	it will not copy the other party’s Confidential Information or permit the
copying of the other party’s Confidential Information in any form other than as
permitted by the other party;
	 
	 	(d)	 	upon request, it will return a party’s Confidential Information to that
party, together with any copies of that party’s Confidential Information; and
	 
	 	(e)	 	it will not make use of the other party’s Confidential Information in any
manner so as to obtain any benefit, right or privilege for itself or for any other
person that would not have been available but for it having access to the
Confidential Information except as permitted by this document.

	5.3	 	Information that is not Confidential Information
	 
	 	 	Clause 5.1 will not apply to any information which:

	 	(a)	 	at the time of disclosure is in the public domain or thereafter becomes
part of the public domain through no fault of the party receiving such information;
	 
	 	(b)	 	the party receiving such information can establish that it was in its
possession prior to the time of disclosure;
	 
	 	(c)	 	is independently made available to the party receiving such information
by a third party who is not thereby in violation of a confidential relationship with
the other party; and
	 
	 	(d)	 	the party receiving such information can conclusively establish that it
was independently developed by the party receiving such information without use of
the Confidential Information of the other party.

Page 6

 

	5.4	 	Permitted disclosures
	 
	 	 	A party may disclose any Confidential Information where disclosure is required by
law or by any notice, order or regulation of any regulatory authority (including the ASX
Listing Rules) which is binding upon a party.
	 
	5.5	 	Public Disclosures
	 
	 	 	Subject to clause 5.4 the Subscriber will not, and will not permit any person
under its control or influence (including any Representative) to, make a public
statement, press release or other communication announcing the Placement before the
Company has announced the Placement.
	 
	6	 	Standstill
	 
	6.1	 	Sale and purchase of Shares
	 
	 	 	Subject to clause 6.2, the Subscriber agrees that during the Standstill Period
neither it, nor, so far as it is able (using its best endeavours) to procure, any of its
Associates or Representatives, will:

	 	(a)	 	directly or indirectly make or cause to be made any offer for, invitation
to dispose of, or solicitation for Securities (or announcement of such an offer or
an intention to make such an offer); or
	 
	 	(b)	 	purchase or otherwise acquire Securities; or
	 
	 	(c)	 	co-operate or assist or enter into any agreement or arrangement of any
kind with any person relating to (or in any way connected with) anything in
paragraphs (a) or (b) above.

	6.2	 	Exceptions
	 
	 	 	Clause 6.1 does not apply to the acquisition of Securities pursuant to the
Placement.
	 
	6.3	 	Disposal of Securities
	 
	 	 	If the Subscriber or any of its Associates or Representatives acquires ownership
of any interest in, or rights over, any Securities in contravention of the provisions of
this document it must promptly dispose, or procure the disposal, of such Securities and
until such disposal the Subscriber will not, and will procure that no other person shall,
exercise any voting rights attached to such Securities.
	 
	7	 	Insider Trading

	 	(a)	 	The Subscriber acknowledges that as a result of its receipt of the
Confidential Information it may be (or be taken to be) in possession of Material Non
Public Information in relation to the Securities.
	 
	 	(b)	 	The Subscriber acknowledges that it is aware of and agrees to comply with
(and that it will ensure that its Representatives who receive access to any part of
the Confidential Information will have been advised of and will comply with)
Securities Laws in respect of the Securities.

Page 7

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