Document:

<PAGE>

                                                                   EXHIBIT 10.17

                    AMENDED AND RESTATED EMPLOYMENT AGREEMENT

            THIS AMENDED AND RESTATED EMPLOYMENT AGREEMENT (the "AGREEMENT") is
made and entered into as of the 2nd day of June, 2004, by and between Stratagene
Corporation, a Delaware corporation formerly known as Stratagene Holding
Corporation ("EMPLOYER"), and Joseph A. Sorge ("EXECUTIVE").

                                    RECITALS

            A. Executive and Employee are parties to that certain Employment
Agreement, dated as of December 6, 1995 (as amended, the "PRIOR EMPLOYMENT
AGREEMENT"), by and among Executive, Employer, Stratagene California, a
California corporation formerly known as Stratagene and a wholly owned
subsidiary of Employer ("STRATAGENE"), and TCW Special Credits Fund V - The
Principal Fund, a California limited partnership (the "FUND").

            B. Employer, SHC Acquisition Sub, Inc., a Delaware corporation and a
wholly owned subsidiary of Employer ("MERGER Sub"), and Hycor Biomedical Inc., a
Delaware corporation ("HYCOR"), have entered into that certain Agreement and
Plan of Reorganization dated as of July 24, 2003, as amended by that certain
Amendment No. 1 to Agreement and Plan of Reorganization dated as of December 29,
2003 by and among Employer, Merger Sub and Hycor and as further amended by that
certain Amendment No. 2 to Agreement and Plan of Reorganization dated as of
February 25, 2004 by and among Employer, Merger Sub and Hycor (as so amended,
the "MERGER AGREEMENT"), pursuant to which Merger Sub will merge with and into
Hycor (the "MERGER") and Hycor will survive the Merger as a wholly owned
subsidiary of Employer.

            C. It is a condition precedent to the closing of the transactions
contemplated by the Merger Agreement that Employer and Executive amend and
restate the Prior Employment Agreement upon the terms and subject to the
conditions herein provided.
<PAGE>
            D. Employer and Executive desire to enter into this Agreement upon
the terms and subject to the conditions herein provided.

                                    AGREEMENT

            NOW, THEREFORE, in consideration of the foregoing premises and
mutual covenants and conditions hereinafter set forth, the parties hereto agree
as follows:

                                   ARTICLE I.
                              EMPLOYMENT AND DUTIES

            1.1 Positions and Duties. Executive shall serve as President and
Chief Executive Officer of Employer, with such duties and authority as are
customary for, and commensurate with, such position and as provided in
Employer's bylaws (as they may be reasonably amended from time to time).
Executive shall also, without any additional compensation, serve as a member of
the Employer's Board of Directors and as Chairman of Employer's Board of
Directors, or as an officer or director of Employer's subsidiaries if elected to
such positions by Employer's Board of Directors, but recognizes that the Board
of Directors has no obligation to elect Executive to such positions. Executive
shall discharge his duties in a loyal and diligent manner. Executive shall
report to the Board of Directors.

            1.2 Activities. During his employment, Executive shall devote
substantially all his working time, interest and effort to the performance of
his duties under this Agreement. Executive shall not have any significant
business activities except for his service to Employer under this Agreement.
Employer agrees that Executive may devote such time to personal investment
activities for himself and his family that are not in conflict with, and do not
interfere with the performance of, Executive's duties to Employer as may be
fairly and reasonably necessary. However, without the prior approval of
Employer's Board of Directors, Executive shall not serve as a director or an
officer (or in any comparable capacity for

                                       2
<PAGE>
any non-corporate entity) of any other company except one of Employer's
subsidiaries or family investment vehicles (including charitable trusts).

                                   ARTICLE II.
                                  COMPENSATION

            2.1 Salary. For Executive's services hereunder, Employer shall pay
to Executive as base salary the amount of $450,000 during each year of the
Employment Term (as hereinafter defined), prorated for any year in which this
Agreement is in effect for only a portion of the calendar year. Said base salary
shall be payable in equal installments in conformity with Employer's normal
payroll practices. Such base salary shall be reviewed on at least an annual
basis by the Compensation Committee of the Board of Directors of Employer (the
"COMPENSATION COMMITTEE") and may be increased from time to time by Employer's
Board of Directors upon the approval of the Compensation Committee in its
discretion. Effective as of the date of any increase, the base salary as so
increased shall be considered the new base salary for all purposes of this
Agreement and may not thereafter be reduced.

            2.2 Bonus. In addition to the base salary set forth in Section 2.1
above, Executive shall be eligible for a bonus, at the discretion of the Board
of Directors upon the recommendation of the Compensation Committee. It is
anticipated that if the Employer establishes any general bonus program for
senior executives based upon the attainment of established goals, that Executive
shall be entitled to participate in such program on a basis at least comparable
to other senior executives.

            2.3 Other Benefits. During the Employment Term, Executive shall be
entitled to participate in and receive all other benefits of employment
generally available to Employer's other executive management personnel,
including, but not limited to, inclusion in Employer's retirement plan, medical
plan, disability plan and other similar benefit plans, subject to and on a basis
consistent with the terms, conditions and overall administration of such plans,
in each case as approved by the Board of Directors, or if authority to establish
such programs is delegated to it, the Compensation Committee.

                                       3
<PAGE>
Employer shall provide, at Employer's expense, Executive the use of the
automobile currently provided for Executive's use, and when such automobile is
sold or exchanged shall provide Executive an automobile consistent with the
Employer's automobile policy for senior executive officers as in effect from
time to time. Employer shall provide Executive office space and administrative
support to assist him to perform his duties and consistent with his position,
which may include reasonable support for personal activities. Executive shall be
entitled to four weeks of paid vacation each year, which will accrue and be paid
out in conformity with Employer's normal vacation pay practices. Executive also
shall be entitled to indemnification by Employer to the fullest extent permitted
by applicable law for all losses arising out of Executive's services as an
employee, officer or director of Employer or any of its subsidiaries, and
Employer shall at all times while this Agreement is in effect include in its
certificate of incorporation a provision making indemnification of its officers
and directors to such extent mandatory. If Employer enters into separate
agreements with its officers or directors providing for indemnification,
Executive shall be entitled to an agreement no less favorable than those
provided to other officers and directors. The Board of Directors, upon the
recommendation of the Compensation Committee, may in its sole discretion grant
such additional benefits to Executive from time to time as they deem proper and
desirable.

            2.4 Expenses. During the term of his employment hereunder, Executive
shall be entitled to receive prompt reimbursement for all reasonable
business-related expenses incurred by him, in accordance with the policies and
procedures from time to time adopted by Employer, including, without limitation,
the requirement that Executive properly account for such business expenses in
accordance with Employer policy.

            2.5 Options. Employer shall grant Executive an option to purchase
738,960 shares of Employer's common stock, par value $0.0001 per share (the
"COMMON STOCK"), at a per share exercise price equal to the Fair Market Value
(as defined below) of a share of Common Stock as of the later of (i) the date of
the closing of the transactions contemplated by the Merger Agreement or (ii) the
first date

                                       4
<PAGE>
on which the Common Stock trades on any established stock exchange or a national
market system, including the Nasdaq National Market of The Nasdaq Stock Market.
Such options shall vest in 4 equal annual installments per full year of
employment pursuant to a stock option agreement to be executed by Employer and
Executive concurrently herewith in substantially the form of Exhibit A attached
hereto.

            The "FAIR MARKET VALUE" of one (1) share of Common Stock shall be
determined in accordance with the terms of the stock option agreement attached
hereto as Exhibit A.

            2.6 Acceleration of Options. The options granted pursuant to Section
2.5, and any other options to purchase Employer's Common Stock which are subject
to a vesting requirement, shall vest immediately prior to the effective time of
a change of control. For purposes of this Agreement, a "CHANGE OF CONTROL" of
Employer shall be deemed to be (i) an acquisition of all or substantially all of
the assets of Employer or (ii) a sale of stock or a merger, consolidation,
reorganization or other combination or acquisition whereby (A) the existing
stockholders of Employer and their affiliates do not retain at least a majority
of the voting power of the capital stock of Employer or the surviving
corporation and (B) a single previously unaffiliated investor owns (including
such unaffiliated investor's affiliates) a majority of the voting power of the
capital stock of Employer or the surviving corporation. In no event shall a
"Change of Control" include a transaction where prior existing stockholders of
Employer and their affiliates hold less than a majority of the outstanding
voting power of Employer's capital stock due to the sale of shares of capital
stock to the public or other investors, so long as no other single previously
unaffiliated investor (including such unaffiliated investor's affiliates) owns a
majority of the voting power of Employer's capital stock.

            2.7 Deductions and Withholdings. All amounts payable or which become
payable under any provision of this Agreement shall be subject to any deductions
authorized by Executive and any deductions and withholdings required by law.

                                       5
<PAGE>
                                  ARTICLE III.
                               TERM OF EMPLOYMENT

            3.1 Term. The term of this Agreement shall commence on the date
hereof and shall continue through June 1, 2007, unless extended as hereinafter
provided (the "EMPLOYMENT TERM").

            3.2 Extension of Term. The Employment Term automatically shall be
extended by one year on each anniversary of its date, unless either party has
given a written notice of non-extension at least thirty (30) days prior to such
anniversary.

            3.3 Termination by Employer. Prior to the expiration of the
Employment Term, Executive's employment may be terminated, and he may be removed
from any position as an officer of Employer or as an officer of Employer or any
of its subsidiaries, either without Cause or for Cause by the action of
Employer's Board of Directors. For these purposes, termination for "CAUSE" shall
mean termination because of Executive's (a) material neglect of or failure to
perform his duties or obligations hereunder, (b) except as permitted by Section
1.2, acceptance of a position with any other company which conflicts with
Executive's duties to Employer, (c) conviction of a felony leading to
incarceration for at least thirty (30) days, or (d) conviction of a criminal
offense having a demonstrably material adverse effect on Employer's financial
condition (as opposed to its stock price), including, without limitation,
offenses under state or federal securities law, or laws prohibiting harassment
or discrimination on the basis of gender, race, nationality, sexual orientation
or religion. Poor financial performance or poor stock price performance of
Employer shall not be in and of itself grounds for termination of Executive for
Cause. The Board of Directors or the Compensation Committee shall deliver
written notice of any alleged Cause to Executive, clearly delineating the
grounds for alleging Cause, and if the basis stated in such notice is clause (a)
or (b) above, Executive shall have thirty (30) days following receipt of such
notice to cure or otherwise eliminate the conditions which are alleged to
constitute grounds for termination for Cause, in either case to the reasonable
satisfaction of the Board of Directors, and if the

                                       6
<PAGE>
basis stated in such notice is clause (d) above, Executive shall have the right
to demonstrate that a conviction referred to in clause (d) should not be
regarded as having a material adverse effect on Employer's financial condition
(as opposed to stock price). If Executive does not cure or otherwise eliminate
such conditions within the thirty-day period or demonstrate the lack of a
material adverse effect, as applicable, the Board of Directors shall deliver
written notice to Executive of any decision to terminate Executive's employment
for Cause, and Executive shall have ten (10) days following receipt of such
notice to demand arbitration of the issue as to whether or not Cause exists.
Such arbitration shall be conducted in accordance with the terms of Section 6.3
below. Termination for Cause shall be effective only upon a final conclusion of
the arbitration, but during the arbitration the Board of Directors may, subject
to reinstatement, suspend Executive, with full pay, benefits, and continued
option vesting, from all duties as an officer or executive of the Employer and
its subsidiaries if it concludes its fiduciary duties to the Employer require
such suspension.

            3.4 Termination by Executive For Good Reason. In the event (a)
Executive's title is reduced or Executive's job responsibilities are materially
reduced without Executive's prior written consent (except in the case of (i) a
suspension contemplated in Section 3.3, (ii) a reduction while Executive is
incapable of performing his duties because of a condition or illness which if it
continued would permit termination of Executive's employment for disability, or
(iii) a change in title or reduction in responsibilities required by a change in
law or the rules of any securities exchange, including a requirement that a
listed company have a non-employee Chairman), (b) Executive's base salary is
reduced or other benefits to be provided to Executive hereunder are materially
reduced (except in the case of a reduction in benefits which applies to all
senior executives in a similar manner), in either case without Executive's prior
written consent, (c) Employer's principal office is relocated outside of the
greater San Diego, California metropolitan area without Executive's prior
written consent, or (d) Employer fails to pay Employee any compensation when
due, then Executive shall have the right to terminate this Agreement by giving
written notice of such termination to Employer and such termination

                                       7
<PAGE>
shall have the same consequences as a termination of Executive by Employer
without Cause. In the case of a claim by Executive under this Section 3.4,
Employer shall have thirty (30) days to cure or otherwise eliminate the alleged
grounds for termination and the right to arbitrate any such claim in accordance
with Section 8.3 below.

            3.5 Termination Due to Death or Disability. Executive's employment
hereunder shall terminate immediately upon his death. In the event that by
reason of major injury, illness or other major physical or mental impairment
Executive shall be (a) substantially unable to perform his services hereunder
for more than 90 consecutive days or (b) substantially unable to perform his
services hereunder for a total of 120 days in any twelve-month period, then
Employer may terminate Executive's employment hereunder. The parties shall agree
upon an independent, qualified physician to evaluate Executive's condition. If
the parties are unable to agree upon the physician to conduct such evaluation,
an independent, qualified physician will be appointed by an arbitrator. If such
independent, qualified physician certifies to Employer's Board of Directors that
any such condition renders Executive substantially unable to perform his duties,
the Board of Directors may assign Executive's duties or authority to others
prior to the completion of the periods described in clauses (a) and (b) of the
preceding sentence, and such assignment of duties or authority shall not be a
basis for Executive to terminate this Agreement under Section 3.4. Executive's
beneficiaries, estate, heirs, representatives or assigns, as appropriate, shall
be entitled to the proceeds, if any, due under any Employer-paid life insurance
policy held by Executive, as determined by and in accordance with the terms of
any such policy, as well as any vested benefits such as accrued vacation
benefits and stock options.

                                   ARTICLE IV.
                    BENEFITS AFTER TERMINATION OF EMPLOYMENT

            4.1 Benefits Upon Termination. Upon termination of Executive's
employment under this Agreement by the Employer under Section 3.3 for Cause or
Section 3.5 due to death or disability) or

                                       8
<PAGE>
upon the resignation of Executive (other than a resignation by Executive under
Section 3.4 (Termination by Executive for Good Reason)), all salary and benefits
of Executive hereunder shall cease immediately; provided, however, that if there
is a termination of this Agreement under Section 3.5 as a result of the
disability of Executive, then Executive shall be entitled to continue to
participate in any medical and disability plans or programs then in effect for
senior executive officers of Employer for the duration of the Employment Term.
If Executive's employment is terminated by Employer without Cause, except for a
termination for death or disability under Section 3.5, or if Executive
terminates his employment under Section 3.4 hereof, Executive shall be entitled
to (a) a lump sum cash severance payment in an amount equal to Executive's then
effective base salary for the remainder of the Term, or if there are fewer than
twelve months remaining in the Term, for twelve months, payable within 10 days
of the date of such termination, and the vesting of all stock options issued to
Executive under any Employer stock option plan, and (b) the inclusion in
Employer's medical plan, disability plan and other benefit plans for the
remainder of the Employment Term. Notwithstanding the foregoing, the Employer
may reduce the severance benefits provided hereunder to the extent reasonably
necessary, based on the written opinion of an independent tax advisor, to avoid
lost deductions under Section 280G of the Code or excise taxes under Section
4999 of the Code (or any successors to such provisions) but shall honor any
reasonable request by Executive about which benefits shall be reduced.

            4.2 Rights Against Employer. The benefits payable under this Article
IV are exclusive, and no amount shall become payable to any person (including
Executive) by reason of the termination of this Agreement under Section 3.3
(Termination by Employer) or Section 3.5 (Termination Due to Death or
Disability) or upon the resignation of Executive, except as otherwise provided
in this Article IV, including, without limitation, under Section 3.4
(Termination by Executive for Good Reason).

                                       9
<PAGE>
                                   ARTICLE V.
                            CONFIDENTIAL INFORMATION

            5.1 Executive acknowledges that Employer holds as confidential, and
Executive has previously had access, and expects to continue to have access
during the Employment Term, to certain information and knowledge respecting the
intimate and confidential affairs of Employer in the various phases of its
business, including, but not limited to, trade secrets, data, improvements,
inventions, techniques, marketing plans, forecasts, pricing information and
customer lists. During his employment by Employer and for a period of no less
than three years thereafter, Executive shall not directly or indirectly disclose
such information to any person or use any such information, except as required
in the course of his employment during the Employment Term. Further, during the
Term and for a period of three years thereafter, Executive agrees not to solicit
for employment, or assist (including by identification as a prospective
candidate) any third party to solicit for employment any person employed by
Employer during the Term or during the three-year period following the Term
without the prior permission of Employer's Board of Directors. However, if
Executive's employment is terminated by Employer or if Executive terminates his
employment for good reason under Section 3.4, the restrictions concerning
solicitation of employees in the preceding sentence shall apply only for sixty
(60) days after such termination.

                                   ARTICLE VI.
                               GENERAL PROVISIONS

            6.1 Entire Agreement. This Agreement contains the entire
understanding and sole and entire agreement between the parties with respect to
the subject matter hereof and supersedes any and all prior agreements,
negotiations and discussions between the parties hereto with respect to the
subject matter covered hereby, including, without limitation, the Prior
Employment Agreement, which shall be of no further force and effect. Each party
to this Agreement acknowledges that no representations,

                                       10
<PAGE>
inducements, promises or agreements, oral or otherwise, have been made by any
party, or anyone acting on behalf of any party, which are not embodied herein,
and that no other agreement, statement or promise not contained in this
Agreement shall be valid or binding. This Agreement may not be modified or
amended by oral agreement, but rather only by an agreement in writing signed by
Employer and Executive which specifically states the intent of the parties to
amend this Agreement.

            6.2 Assignment and Binding Effect. Neither this Agreement nor his
rights or obligations hereunder shall be assignable by Executive. Employer may
assign this Agreement to any successor of Employer, and upon such assignment any
such successor shall be deemed substituted for Employer upon the terms and
subject to the conditions hereof.

            6.3 Arbitration. The parties hereto agree that disputes between
Executive and the Employer under this Agreement shall be submitted to final and
binding arbitration, unless the parties otherwise agree. Such arbitration shall
take place in San Diego, California pursuant to the Employment Dispute Rules of
the American Arbitration Association ("AAA"), except as otherwise agreed to by
the parties. The arbitrator shall be selected by the AAA, and such selection is
intended to be private, confidential and decided on an expedited basis. The
parties hereto agree that (a) they will request the AAA and the arbitrator that
the matter be heard within sixty (60) days after the demand is submitted and the
decision be rendered within ten (10) days after the hearing is concluded, (b)
both parties will keep confidential the filing of the arbitration (except to the
extent the Employer concludes that a public announcement is appropriate under
applicable securities laws or stock exchange policies or regulations) and the
evidence and other information exchanged and (c) the decision of the arbitrator
shall be final, binding and non-appealable. Employer shall pay the fees of the
AAA and the arbitrator and expenses associated with such proceeding. At the
request of the prevailing party, the arbitrator may award the costs and expenses
of the arbitration (including the prevailing party's attorney fees and expenses)
as a component of the damages, if any, sustained by the prevailing party, but
shall not have the authority to award punitive or exemplary damages.

                                       11
<PAGE>
            6.4 No Waiver. No waiver of any term, provision or condition of this
Agreement, whether by conduct or otherwise, in any one or more instances shall
be deemed or be construed as a further or continuing waiver of any such term,
provision or condition, or as a waiver of any other term, provision or condition
of this Agreement.

            6.5 Governing Law; Rules of Construction. This Agreement has been
negotiated and executed in, and shall be governed by and construed in accordance
with the laws of, the State of California. Captions of the several Articles and
Sections of this Agreement are for convenience of reference only, and shall not
be considered or referred to in resolving questions of interpretation with
respect to this Agreement.

            6.6 Notices. Any notice, request, demand or other communication
required or permitted hereunder shall be deemed to be properly given when
personally served in writing, or when deposited in the United States mail,
postage pre-paid, addressed to Employer or Executive at their respective
addresses set forth below. Each party may change its address by written notice
in accordance with this Section 6.6.

            Address for Employer:      Stratagene Corporation
                                       11011 North Torrey Pines Road
                                       La Jolla, California  92037
                                       Attention:  Chief Financial Officer

            Address for Executive:     Joseph A. Sorge
                                       144 10th Street
                                       Del Mar, California  92014

            6.7 Severability. The provisions of this Agreement are severable. If
any provision of this Agreement shall be held to be invalid or otherwise
unenforceable, in whole or in part, the remainder of the provisions or
enforceable parts hereof shall not be affected thereby and shall be enforced to
the fullest extent permitted by law.

                                       12
<PAGE>
            6.8 Multiple Counterparts. This Agreement may be executed in one or
more counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       13
<PAGE>
            IN WITNESS WHEREOF, this Agreement has been executed and delivered
by the parties hereto as of the date first above written.

                                             EMPLOYER:

                                             STRATAGENE CORPORATION,
                                             a Delaware corporation

                                             By: /s/ RONNI L. SHERMAN
                                                 -----------------------------
                                             Name: Ronni L. Sherman
                                                   ---------------------------
                                             Title: Executive Vice President and
                                                    General Counsel
                                                    --------------------------

                                             EXECUTIVE:

                                             /s/ JOSEPH A. SORGE
                                             ---------------------------------

                                             JOSEPH A. SORGE

                                       14
<PAGE>
                                    EXHIBIT A

                         FORM OF STOCK OPTION AGREEMENT

                            [INTENTIONALLY OMITTED]<PAGE>

                                                                   EXHIBIT 10.18

                            UNSECURED PROMISSORY NOTE

U.S. $1,669,540.07                                         San Diego, California
                                                                    June 2, 2004

      FOR VALUE RECEIVED, the undersigned, Stratagene Corporation, a Delaware
corporation ("OBLIGOR"), hereby promises to pay to Joseph A. Sorge, M.D., an
individual ("HOLDER"), the principal sum of One Million Six Hundred Sixty Nine
Thousand Five Hundred Forty and 07/100 Dollars ($1,669,540.07), together with
interest thereon at the times and in the amounts set forth below.

      1. Interest Rate. The unpaid principal amount hereof shall bear interest
from the date hereof until all principal and accrued and unpaid interest hereon
is paid in full at a rate of 3.89% per annum, compounded annually (which rate is
the lowest applicable rate permissible under the Internal Revenue Code of 1986,
as amended, without the imputation of interest income or expense). Interest
shall be payable in arrears on the payment dates set forth in Section 2 hereof
based on a year consisting of twelve months, each consisting of 30 days.

      2. Payment.

            (a) All payments of principal and interest under this Note shall be
in lawful money of the United States of America. All payments will be applied
first to the cost of collection, if any, then to accrued and unpaid interest,
and thereafter to principal. In the event that a payment hereunder becomes due
and payable on a day other than a business day on which banks in the State of
California are open for business, such payment shall become due and payable on
the next succeeding business day on which banks in the State of California are
open for business. All payments will be by wire transfer of immediately
available funds to an account designated in writing by Holder.

            (b) Obligor will pay 1/39th of the outstanding principal balance of
this Note and the accrued but unpaid interest thereon (the "TOTAL AMOUNT") on
July 1, 2004 (such payment, the "MONTHLY TOTAL AMOUNT"). Thereafter, Obligor
shall pay principal installments equal to the Monthly Total Amount and interest
installments equal to the amount of the unpaid interest accrued on the Total
Amount on the first day of the subsequent month, and continuing on the same day
of each month thereafter until the Maturity Date (as defined below), at which
time the entire remaining balance of principal and accrued interest on the Note
shall be due and payable. As used herein, the term "MATURITY DATE" shall mean
September 1, 2007.

      3. Default. Each of the following events shall be an "EVENT OF DEFAULT"
hereunder:

            (a) Obligor fails to make within five (5) business days of when due
any payment of principal, interest or other amounts owing hereunder;

            (b) Obligor files any petition or action for relief under any
bankruptcy, reorganization, insolvency or moratorium law or any other law for
the relief of, or relating to, debtors, now or hereafter in effect, or makes any
assignment for the benefit of creditors or takes any corporate action in
furtherance of any of the foregoing; or

            (c) an involuntary petition is filed against Obligor (unless such
petition is dismissed or discharged within sixty (60) days of filing) under any
bankruptcy statute now or hereafter in effect, or a custodian, receiver,
trustee, assignee for the benefit of creditors (or other similar official) is
appointed to take possession, custody or control of any property of Obligor.
<PAGE>
Upon the occurrence of an Event of Default hereunder, all unpaid principal,
accrued interest and other amounts owing hereunder shall, at the option of
Holder, and, in the case of an Event of Default pursuant to clauses (b) or (c)
above, automatically, be immediately due, payable and collectible by Holder
pursuant to applicable law.

      4. Prepayment. This Note may be prepaid, in whole or in part, at any time
and from time to time, without penalty or premium; provided, however, that any
such prepayment shall first be applied against any accrued and unpaid interest,
and the balance shall be applied against the principal.

      5. Usury. Anything in this Note to the contrary notwithstanding, if at any
time the rate of interest on the Note together with all fees and charges, if any
(collectively, the "CHARGES"), contracted for, charged, received, taken or
reserved by Holder which may be treated as interest under applicable law,
computed over the full term of the Note, exceeds the maximum legal limit (if any
such limit is applicable) under United States federal law or state law (to the
extent not preempted by federal law, if any), now or hereafter governing the
interest payable on the Note (the "MAXIMUM RATE"), then the rate of interest on
the Note, together with all Charges, shall be limited to the Maximum Rate. If
from any circumstances Holder shall ever receive as interest an amount which
would exceed the Maximum Rate, such amount which would be excessive interest
shall be applied to the reduction of the unpaid principal balance hereunder
(whether or not due and payable) and not to the payment of interest.

      6. Costs and Expenses of Collection. If this Note is collected by or
through an attorney at law as a result of a failure of Obligor to pay, when due
hereunder, any payment of principal of or other amount due under this Note,
Obligor shall pay all of the Holder's reasonably incurred costs of collection,
including, without limitation, Holder's attorneys' fees.

      7. Miscellaneous.

            (a) Presentment, demand, protest, notices of protest, dishonor and
non-payment of this Note and all notices of every kind are hereby waived. To the
extent permitted by applicable law, the defense of the statute of limitations is
hereby waived by Obligor.

            (b) No single or partial exercise of any power hereunder shall
preclude other or further exercise thereof or the exercise of any other power.
No delay or omission on the part of the holder hereof in exercising any right
hereunder shall operate as a waiver of such right or of any other right under
this Note. No waiver of any breach of any of the covenants or conditions of this
Note shall be construed to be a waiver of or acquiescence in or a consent to any
previous or subsequent breach of the same or any other condition or covenant.

            (c) No right, power or remedy conferred upon or reserved to the
holder hereof by this Note is intended to be exclusive of any other right, power
or remedy, but each and every such right, power and remedy shall be cumulative
and concurrent and shall be in addition to any other right, power and remedy
given hereunder or now or hereafter existing at law or in equity or by statute.
Every power or remedy given by this Note to the holder hereof or to which such
holder may be entitled may be exercised from time to time and as often as may be
deemed expedient by such holder.

            (d) This Note shall be governed by and construed in accordance with
the internal laws of the State of California without regard to principles of
conflicts of laws.

            (e) Time is hereby declared to be of the essence of this Note and of
every part hereof. When the context and construction so require, all words used
in the singular herein shall be deemed to have been used in the plural and the
masculine shall include the feminine and the neuter and

                                       2
<PAGE>
vice versa. Titles and sections are for convenience only and neither limit nor
amplify the provisions of this Note, and all references herein to sections or
paragraphs shall refer to the corresponding sections or paragraphs of this Note
unless specific reference is made to such sections or paragraphs of another
document or instrument.

            (f) If any provision of this Note or the application thereof to any
person or circumstance shall be invalid or unenforceable to any extent, the
remainder of this Note and the application of such provision to other persons or
circumstances shall not be affected thereby and shall be enforced to the maximum
extent permitted by law.

            (g) Any and all notices required by this Note shall be personally
delivered or sent by certified mail, return receipt requested, or sent by
machine confirmed facsimile transmission, addressed to a party at its address
set forth below, or at such other address as it may designate to the other party
in accordance with this paragraph. A notice shall be deemed effective when
delivered if personally delivered, three (3) business days following mailing if
sent by certified mail, return receipt requested, and upon machine confirmation
of transmission when sent by facsimile.

               If to Obligor:                         If to Holder:

               Stratagene Corporation                 Joseph A. Sorge, M.D.
               11011 North Torrey Pines Road          144 10th Street
               La Jolla, California  92037            Del Mar, California  92014
               Attention:  Chief Financial Officer    Facsimile:  (858) 509-4899
               Facsimile:  (858) 535-0071

            The parties hereto may change their addresses by giving notice
thereof to the other parties hereto in conformity with this section.

            (h) This Note may not be assigned by Obligor without the prior
written consent of the holder hereof. This Note or any interest hereunder may be
freely assigned by the holder hereof without the consent of Obligor. Subject to
the foregoing, this Note shall inure to the benefit of the holder hereof, its
successors, assigns and representatives and shall bind Obligor, its successors,
assigns and representatives. This Note may not be modified, amended or
terminated except by a written agreement signed by Obligor and the holder
hereof.

            (i) No director, officer or employee, as such, of Obligor shall have
any liability for any obligations of Obligor under the Note or for any claim
based on, in respect of or by reason of such obligation or its creation. By
accepting this Note, Holder waives and releases all such liability. The waiver
and release are part of the consideration for the Note.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       3
<PAGE>
      IN WITNESS WHEREOF, Obligor has executed and delivered this Note effective
as of the date first written above.

                                          OBLIGOR

                                          STRATAGENE CORPORATION

                                          By: /s/ RONNI L. SHERMAN
                                              ----------------------------------
                                                  Ronni L. Sherman
                                                  Executive Vice President and
                                                  General Counsel

                                       4

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00070-of-00352.parquet"}]]