Document:

NEITHER
THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE
COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO,
THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A
LEGAL OPINION OF COUNSEL TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.
THIS SECURITY AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS SECURITY MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN
ACCOUNT OR OTHER LOAN SECURED BY SUCH SECURITIES.

 

COMMON
STOCK PURCHASE WARRANT

 

PRESSURE
BIOSCIENCES, INC.

 

	Warrant
    Shares: ______	Initial
    Exercise Date: ______ _____
	 	Issue
    Date: _______ ______

 

THIS
COMMON STOCK PURCHASE WARRANT (the “Warrant”) certifies that, for value received, ______ or its assigns (the
“Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter
set forth, at any time on or after ______ (the “Initial Exercise Date”) and on or prior to the close of business
on the five year anniversary of the Initial Exercise Date (the “Termination Date”) but not thereafter, to subscribe
for and purchase from Pressure BioSciences, Inc., a Massachusetts corporation (the “Company”), up to ______
shares (as subject to adjustment hereunder, the “Warrant Shares”) of Common Stock. The purchase price of one
share of Common Stock under this Warrant shall be equal to the Exercise Price, as defined in Section 1(b).

 

Section
1. Exercise.

 

a)
Exercise of Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part, at any
time or times on or after the Initial Exercise Date and on or before the Termination Date by delivery to the Company (or such
other office or agency of the Company as it may designate by notice in writing to the registered Holder at the address of the
Holder appearing on the books of the Company) of a duly executed facsimile copy of the Notice of Exercise form annexed hereto
and within three (3) Trading Days of the date said Notice of Exercise is delivered to the Company, the Company shall have received
payment of the aggregate Exercise Price of the shares thereby purchased by wire transfer or cashier’s check drawn on a United
States bank or, if available, pursuant to the cashless exercise procedure specified in Section 1(c) below. No ink-original Notice
of Exercise shall be required, nor shall any medallion guarantee (or other type of guarantee or notarization) of any Notice of
Exercise form be required. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender
this Warrant to the Company until the Holder has purchased all of the Warrant Shares available hereunder and the Warrant has been
exercised in full, in which case, the Holder shall surrender this Warrant to the Company for cancellation within three (3) Trading
Days of the date the final Notice of Exercise is delivered to the Company. Partial exercises of this Warrant resulting in purchases
of a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the outstanding number
of Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Holder and
the Company shall maintain records showing the number of Warrant Shares purchased and the date of such purchases. The Company
shall deliver any objection to any Notice of Exercise Form within two (2) Business Days of receipt of such notice. The Holder
and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following
the purchase of a portion of the Warrant Shares hereunder, the number of Warrant Shares available for purchase hereunder at any
given time may be less than the amount stated on the face hereof.

 

    	 	 	 

     

    

 

b)
Exercise Price. The exercise price per share of the Common Stock under this Warrant shall be forty cents $.40.

 

c)
Cashless Exercise. This Warrant may be exercised, in whole or in part, by means of a “cashless exercise” in
accordance with this Section 1(c), if at any time after the earlier of: (i) the 180 day anniversary of the date of the Initial
Exercise Date; and (ii) the completion of the then-applicable holding period required by Rule 144, or any successor provision
then in effect, there is no effective Registration Statement registering, or no current prospectus available for, the resale of
the Warrant Shares by the Holder, then this Warrant may be exercised, in whole or in part, at such time by means of a “cashless
exercise.” Pursuant to a cashless exercise, the Holder shall be entitled to receive a number of Warrant Shares equal to
the quotient obtained by dividing [(A-B) (X)] by (A), where:

 

	 	(A)
    =	the
    VWAP (as defined below) on the Trading Day immediately preceding the date on which Holder elects to exercise this Warrant
    by means of a “cashless exercise,” as set forth in the applicable Notice of Exercise;
	 	 	 
	 	(B)
    =	the
    Exercise Price of this Warrant, as adjusted hereunder; and
	 	 	 
	 	(X)
    =	the
    number of Warrant Shares that would be issuable upon exercise of this Warrant in accordance with the terms of this Warrant
    if such exercise were by means of a cash exercise rather than a cashless exercise.

 

“VWAP”
means, for any date, the volume-weighted average price of the common stock on the Principal Market for a particular Trading Day
or set of Trading Days, as the case may be, as reported by Bloomberg. “Trading Day” means any day during which
the principal market on which the common stock is traded (the “Principal Market”) shall be open for business.

 

d)
Mechanics of Exercise.

 

i.
Delivery of Warrant Shares Upon Exercise. Warrant Shares purchased hereunder shall be transmitted by the Transfer Agent
to the Holder by crediting the account of the Holder’s prime broker with The Depository Trust Company through its Deposit
or Withdrawal at Custodian system (“DWAC”) if the Company is then a participant in such system and either (A) there
is an effective registration statement permitting the issuance of the Warrant Shares to or resale of the Warrant Shares by the
Holder or (B) the shares are eligible for resale by the Holder without the holding period, volume or manner-of-sale limitations
pursuant to Rule 144, and otherwise by physical delivery to the address specified by the Holder in the Notice of Exercise by the
date that is three (3) Trading Days after the latest of (A) the delivery to the Company of the Notice of Exercise and (B) surrender
of this Warrant (if required) (such date, the “Warrant Share Delivery Date”). The Warrant Shares shall be deemed
to have been issued, and Holder or any other person so designated to be named therein shall be deemed to have become a holder
of record of such shares for all purposes, as of the date the Warrant has been exercised, with payment to the Company of the Exercise
Price (or by cashless exercise, if permitted) and all taxes required to be paid by the Holder, if any, pursuant to Section 1(d)(vi)
prior to the issuance of such shares, having been paid.

 

ii.
Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request
of a Holder and upon surrender of this Warrant certificate, at the time of delivery of the Warrant Shares, deliver to the Holder
a new Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant, which
new Warrant shall in all other respects be identical with this Warrant.

 

iii.
Rescission Rights. If the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares pursuant
to Section 1(d)(i) by the Warrant Share Delivery Date, then the Holder will have the right to rescind such exercise.

 

    	 	 	 

     

    

 

iv.
Compensation for Buy-In on Failure to Timely Deliver Warrant Shares Upon Exercise. In addition to any other rights available
to the Holder, if the Company fails to cause the Transfer Agent to transmit to the Holder the Warrant Shares pursuant to an exercise
on or before the Warrant Share Delivery Date, and if after such date the Holder is required by its broker to purchase (in an open
market transaction or otherwise) or the Holder’s brokerage firm otherwise purchases, shares of Common Stock to deliver in
satisfaction of a sale by the Holder of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”),
then the Company shall (A) pay in cash to the Holder the amount, if any, by which (x) the Holder’s total purchase price
(including brokerage commissions, if any) for the shares of Common Stock so purchased exceeds (y) the amount obtained by multiplying
(1) the number of Warrant Shares that the Company was required to deliver to the Holder in connection with the exercise at issue
times (2) the price at which the sell order giving rise to such purchase obligation was executed, and (B) at the option of the
Holder, either reinstate the portion of the Warrant and equivalent number of Warrant Shares for which such exercise was not honored
(in which case such exercise shall be deemed rescinded) or deliver to the Holder the number of shares of Common Stock that would
have been issued had the Company timely complied with its exercise and delivery obligations hereunder. For example, if the Holder
purchases Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect to an attempted exercise of shares
of Common Stock with an aggregate sale price giving rise to such purchase obligation of $10,000, under clause (A) of the immediately
preceding sentence the Company shall be required to pay the Holder $1,000. The Holder shall provide the Company written notice
indicating the amounts payable to the Holder in respect of the Buy-In and, upon request of the Company, evidence of the amount
of such loss. Nothing herein shall limit a Holder’s right to pursue any other remedies available to it hereunder, at law
or in equity including, without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s
failure to timely deliver shares of Common Stock upon exercise of the Warrant as required pursuant to the terms hereof.

 

v.
No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the exercise
of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such exercise, the
Company shall, at its election, either pay a cash adjustment in respect of such final fraction in an amount equal to such fraction
multiplied by the Exercise Price or round up to the next whole share.

 

vi.
Charges, Taxes and Expenses. Issuance of Warrant Shares shall be made without charge to the Holder for any issue or transfer
tax or other incidental expense in respect of the issuance of Warrant Shares, all of which taxes and expenses shall be paid by
the Company, and such Warrant Shares shall be issued in the name of the Holder or in such name or names as may be directed by
the Holder; provided, however, that in the event that Warrant Shares are to be issued in a name other than the name
of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed
by the Holder and the Company may require, as a condition thereto, the payment of a sum sufficient to reimburse it for any transfer
tax incidental thereto. The Company shall pay all Transfer Agent fees required for same-day processing of any Notice of Exercise.

 

vii.
Closing of Books. The Company will not close its stockholder books or records in any manner which prevents the timely exercise
of this Warrant, pursuant to the terms hereof.

 

    	 	 	 

     

    

 

e)
Holder’s Exercise Limitations. The Company shall not effect any exercise of this Warrant, and a Holder shall not
have the right to exercise any portion of this Warrant, pursuant to Section 1 or otherwise, to the extent that after giving effect
to such issuance after exercise as set forth on the applicable Notice of Exercise, the Holder (together with the Holder’s
Affiliates, and any other Persons acting as a group together with the Holder or any of the Holder’s Affiliates), would beneficially
own in excess of the Beneficial Ownership Limitation (as defined below). For purposes of the foregoing sentence, the number of
shares of Common Stock beneficially owned by the Holder and its Affiliates shall include the number of shares of Common Stock
issuable upon exercise of this Warrant with respect to which such determination is being made, but shall exclude the number of
shares of Common Stock which are issuable upon: (i) exercise of the remaining, nonexercised portion of this Warrant beneficially
owned by the Holder or any of its Affiliates; and (ii) exercise or conversion of the unexercised or nonconverted portion of any
other securities of the Company subject to a limitation on conversion or exercise analogous to the limitation contained herein
(including, without limitation, any other Warrants of the Debentures) beneficially owned by the Holder or any of its Affiliates.
Except as set forth in the preceding sentence, for purposes of this Section 1(e), beneficial ownership shall be calculated in
accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder, it being acknowledged
by the Holder that the Company is not representing to the Holder that such calculation is in compliance with Section 13(d) of
the Exchange Act and the Holder is solely responsible for any schedules required to be filed in accordance therewith. To the extent
that the limitation contained in this Section 1(e) applies, the determination of whether this Warrant is exercisable (in relation
to other securities owned by the Holder together with any Affiliates) and of which portion of this Warrant is exercisable shall
be in the sole discretion of the Holder, and the submission of a Notice of Exercise shall be deemed to be the Holder’s determination
of whether this Warrant is exercisable (in relation to other securities owned by the Holder together with any Affiliates) and
of which portion of this Warrant is exercisable, in each case subject to the Beneficial Ownership Limitation. To ensure compliance
with this restriction, the Holder will be deemed to represent to the Company each time it delivers a Notice of Conversion that
such Notice of Conversion has not violated the restrictions set forth in this paragraph and the Company shall have no obligation
to verify or confirm the accuracy of such determination. In addition, a determination as to any group status as contemplated above
shall be determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder.
For purposes of this Section 1(e), in determining the number of outstanding shares of Common Stock, a Holder may rely on the number
of outstanding shares of Common Stock as stated in the most recent of the following: (A) the Company’s most recent periodic
or annual report filed with the Commission, as the case may be; (B) a more recent public announcement by the Company; or (C) a
more recent written notice by the Company or the Transfer Agent setting forth the number of shares of Common Stock outstanding.
Upon the written or oral request of a Holder, the Company shall within two Trading Days confirm orally and in writing to the Holder
the number of shares of Common Stock then outstanding. In any case, the number of outstanding shares of Common Stock shall be
determined after giving effect to the conversion or exercise of securities of the Company, including this Warrant, by the Holder
or its Affiliates since the date as of which such number of outstanding shares of Common Stock was reported. The “Beneficial
Ownership Limitation” shall be 4.99% of the number of shares of the Common Stock outstanding immediately after giving
effect to the issuance of shares of Common Stock issuable upon exercise of this Warrant held by the Holder. The Holder, upon not
less than 61 days’ prior notice to the Company, may increase or decrease the Beneficial Ownership Limitation provisions
of this Section 1(e), provided that the Beneficial Ownership Limitation in no event exceeds 9.99% of the number of shares of the
Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock upon exercise of this Warrant
held by the Holder and the provisions of this Section 1(e) shall continue to apply. Any such increase or decrease will not be
effective until the 61st day after such notice is delivered to the Company. The Beneficial Ownership Limitation provisions
of this paragraph shall be construed and implemented in a manner otherwise than in strict conformity with the terms of this Section
1(e) to correct this paragraph (or any portion hereof) which may be defective or inconsistent with the intended Beneficial Ownership
Limitation contained herein or to make changes or supplements necessary or desirable to properly give effect to such limitation.
The limitations contained in this paragraph shall apply to a successor holder of this Warrant.

 

Section
2. Certain Adjustments.

 

a)
Stock Dividends and Stock Splits. If the Company, at any time while this Warrant is outstanding: (i) pays a stock dividend
or otherwise makes a distribution or distributions payable in shares of Common Stock on shares of Common Stock or any Common Stock
Equivalents (which, for avoidance of doubt, shall not include any shares of Common Stock issued by the Company upon conversion
of, or payment of interest on, the Debentures or upon the exercise of any options or warrants, including the Warrants); (ii) subdivides
outstanding shares of Common Stock into a larger number of shares; (iii) combines (including by way of a reverse stock split)
outstanding shares of Common Stock into a smaller number of shares; or (iv) issues, in the event of a reclassification of shares
of the Common Stock, any shares of capital stock of the Company, then the Exercise Price shall be multiplied by a fraction of
which the numerator shall be the number of shares of Common Stock (excluding any treasury shares of the Company) outstanding immediately
before such event and of which the denominator shall be the number of shares of Common Stock outstanding immediately after such
event, and the number of shares issuable upon exercise of this Warrant shall be proportionately adjusted such that the aggregate
Exercise Price of this Warrant shall remain unchanged. Any adjustment made pursuant to this Section 2(a) shall become effective
immediately after the record date for the determination of stockholders entitled to receive such dividend or distribution and
shall become effective immediately after the effective date in the case of a subdivision, combination or re-classification.

 

    	 	 	 

     

    

 

b)
Fundamental Transaction. If, at any time while this Warrant is outstanding: (i) the Company, directly or indirectly, in
one or more related transactions effects any merger or consolidation of the Company with or into another Person; (ii) the Company,
directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition of all or substantially
all of its assets in one or a series of related transactions; (iii) any, direct or indirect, purchase offer, tender offer or exchange
offer (whether by the Company or another Person) is completed pursuant to which holders of Common Stock are permitted to sell,
tender or exchange their shares for other securities, cash or property and has been accepted by the holders of more than 50% of
the outstanding Common Stock; (iv) the Company, directly or indirectly, in one or more related transactions effects any reclassification,
reorganization or recapitalization of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is
effectively converted into or exchanged for other securities, cash or property; or (v) the Company, directly or indirectly, in
one or more related transactions consummates a stock or share purchase agreement or other business combination (including, without
limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person or group of Persons whereby
such other Person or group acquires more than 50% of the outstanding shares of Common Stock (not including any shares of Common
Stock held by the other Person or other Persons making or party to, or associated or affiliated with the other Persons making
or party to, such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”),
then, upon any subsequent exercise of this Warrant, the Holder shall have the right to receive, for each Warrant Share that would
have been issuable upon such exercise immediately prior to the occurrence of such Fundamental Transaction (without regard to any
limitation in Section 1(e) on the exercise of this Warrant), the number of shares of Common Stock of the successor or acquiring
corporation or of the Company, if it is the surviving corporation, and any additional consideration (the “Alternate Consideration”)
receivable as a result of such Fundamental Transaction by a holder of the number of shares of Common Stock for which this Warrant
is exercisable immediately prior to such Fundamental Transaction (without regard to any limitation in Section 1(e) on the exercise
of this Warrant). For purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted to
apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one (1) share of Common
Stock in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in
a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common
Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder
shall be given the same choice as to the Alternate Consideration it receives upon any exercise of this Warrant following such
Fundamental Transaction. The Company shall cause any successor entity in a Fundamental Transaction in which the Company is not
the survivor (the “Successor Entity”) to assume in writing all of the obligations of the Company under this
Warrant and the other Transaction Documents in accordance with the provisions of this Section 2(b) pursuant to written agreements
in form and substance reasonably satisfactory to the holders of a majority of the Warrants prior to such Fundamental Transaction
and shall, at the option of the Holder, deliver to the Holder in exchange for this Warrant a security of the Successor Entity
evidenced by a written instrument substantially similar in form and substance to this Warrant which is exercisable for a corresponding
number of shares of capital stock of such Successor Entity (or its parent entity) equivalent to the shares of Common Stock acquirable
and receivable upon exercise of this Warrant (without regard to any limitations on the exercise of this Warrant) prior to such
Fundamental Transaction, and with an exercise price which applies the exercise price hereunder to such shares of capital stock
(but taking into account the relative value of the shares of Common Stock pursuant to such Fundamental Transaction and the value
of such shares of capital stock, such number of shares of capital stock and such exercise price being for the purpose of protecting
the economic value of this Warrant immediately prior to the consummation of such Fundamental Transaction), and which is reasonably
satisfactory in form and substance to the Holder. Upon the occurrence of any such Fundamental Transaction, the Successor Entity
shall succeed to, and be substituted for (so that from and after the date of such Fundamental Transaction, the provisions of this
Warrant and the other Transaction Documents referring to the “Company” shall refer instead to the Successor Entity),
and may exercise every right and power of the Company and shall assume all of the obligations of the Company under this Warrant
and the other Transaction Documents with the same effect as if such Successor Entity had been named as the Company herein.

 

    	 	 	 

     

    

 

c)
Calculations. All calculations under this Section 2 shall be made to the nearest cent or the nearest 1/100th of a share,
as the case may be. For purposes of this Section 2, the number of shares of Common Stock deemed to be issued and outstanding as
of a given date shall be the sum of the number of shares of Common Stock (excluding any treasury shares of the Company) issued
and outstanding.

 

d)
Notice to Holder.

 

	 	i	Adjustment
    to Exercise Price. Whenever the Exercise Price is adjusted pursuant to any provision of this Section 2, the Company shall
    promptly deliver to each Holder a notice setting forth the Exercise Price after such adjustment and any resulting adjustment
    to the number of Warrant Shares and setting forth a brief statement of the facts requiring such adjustment.
	 	 	 
	 	ii	Notice
    to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever form)
    on the Common Stock, (B) the Company shall declare a special nonrecurring cash dividend on or a redemption of the Common Stock,
    (C) the Company shall authorize the granting to all holders of the Common Stock of rights or warrants to subscribe for or
    purchase any shares of capital stock of any class or of any rights, (D) the approval of any stockholders of the Company shall
    be required in connection with any reclassification of the Common Stock, any consolidation or merger to which the Company
    is a party, any sale or transfer of all or substantially all of the assets of the Company, or any compulsory share exchange
    whereby the Common Stock is converted into other securities, cash or property, or (E) the Company shall authorize the voluntary
    or involuntary dissolution, liquidation or winding up of the affairs of the Company, then, in each case, the Company shall
    cause to be filed at each office or agency maintained for the purpose of exercise of this Warrant, and shall cause to be delivered
    to the Holder at its last address as it shall appear upon the Warrant Register of the Company, at least ten (10) calendar
    days prior to the applicable record or effective date hereinafter specified, a notice stating (x) the date on which a record
    is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record is not to be
    taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions, redemption,
    rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale, transfer
    or share exchange is expected to become effective or close, and the date as of which it is expected that holders of the Common
    Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable
    upon such reclassification, consolidation, merger, sale, transfer or share exchange; provided that the failure to deliver
    such notice or any defect therein or in the delivery thereof shall not affect the validity of the corporate action required
    to be specified in such notice. To the extent that any notice provided hereunder constitutes, or contains, material, non-public
    information regarding the Company or any of the Subsidiaries, the Company shall simultaneously file such notice with the Commission
    pursuant to a Current Report on Form 8-K. The Holder shall remain entitled to exercise this Warrant during the period commencing
    on the date of such notice to the effective date of the event triggering such notice except as may otherwise be expressly
    set forth herein.

 

(e)
For purposes of this Warrant, the term “Exempt Issuance” shall mean the issuance of (a) shares of Common Stock
or options or other stock based awards to employees, officers or directors and consultants of the Company pursuant to the Company’s
stock or option plans existing as of the date hereof and to also include up to 2,500,000 shares of Common Stock (subject to adjustment
for forward and reverse stock splits, recapitalizations and the like), in the aggregate, to employees, officers or directors and
consultants of the Company pursuant to a written agreement, provided that such shares of Common Stock are not registered and carry
no registration rights other than on Form S-8, (c) securities upon the exercise or exchange of or conversion of any Securities
issued hereunder and/or other securities exercisable or exchangeable for or convertible into shares of Common Stock issued and
outstanding on the Original Issue Date of this Debenture, provided that such securities have not been amended since the date of
this Agreement to increase the number of such securities or to decrease the exercise price, exchange price or conversion price
of such securities, and (d) securities issued pursuant to acquisitions or strategic transactions approved by a majority of the
disinterested directors of the Company, provided that any such issuance shall only be to a Person (or to the equity holders of
a Person) which is, itself or through its subsidiaries, an operating company or an owner of an asset in a business synergistic
with the business of the Company and shall provide to the Company additional benefits in addition to the investment of funds,
but shall not include a transaction in which the Company is issuing securities primarily for the purpose of raising capital or
to an entity whose primary business is investing in securities.

 

    	 	 	 

     

    

 

Section
3. Transfer of Warrant.

 

a)
Transferability. Subject to compliance with any applicable securities laws and the conditions set forth in Section 3(d)
hereof, this Warrant and all rights hereunder (including, without limitation, any registration rights) are transferable, in whole
or in part, upon surrender of this Warrant at the principal office of the Company or its designated agent, together with a written
assignment of this Warrant substantially in the form attached hereto duly executed by the Holder or its agent or attorney and
funds sufficient to pay any transfer taxes payable upon the making of such transfer. Upon such surrender and, if required, such
payment, the Company shall execute and deliver a new Warrant or Warrants in the name of the assignee or assignees, as applicable,
and in the denomination or denominations specified in such instrument of assignment, and shall issue to the assignor a new Warrant
evidencing the portion of this Warrant not so assigned, and this Warrant shall promptly be cancelled. Notwithstanding anything
herein to the contrary, the Holder shall not be required to physically surrender this Warrant to the Company unless the Holder
has assigned this Warrant in full, in which case, the Holder shall surrender this Warrant to the Company within three (3) Trading
Days of the date the Holder delivers an assignment form to the Company assigning this Warrant full. The Warrant, if properly assigned
in accordance herewith, may be exercised by a new holder for the purchase of Warrant Shares without having a new Warrant issued.

 

b)
New Warrants. This Warrant may be divided or combined with other Warrants upon presentation hereof at the aforesaid office
of the Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued,
signed by the Holder or its agent or attorney. Subject to compliance with Section 3(a), as to any transfer which may be
involved in such division or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the
Warrant or Warrants to be divided or combined in accordance with such notice. All Warrants issued on transfers or exchanges shall
be dated the original Issue Date and shall be identical with this Warrant except as to the number of Warrant Shares issuable pursuant
thereto.

 

c)
Warrant Register. The Company shall register this Warrant, upon records to be maintained by the Company for that purpose
(the “Warrant Register”), in the name of the record Holder hereof from time to time. The Company may deem and
treat the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution
to the Holder, and for all other purposes, absent actual notice to the contrary.

 

d)
Transfer Restrictions; . At the time of the surrender of this Warrant in connection with any transfer of this Warrant,
the transfer of this Warrant shall be either: (i) registered pursuant to an effective registration statement under the Securities
Act and under applicable state securities or blue sky laws or exempt therefrom; or (ii) eligible for resale without holding period,
volume or manner-of-sale restrictions or current public information requirements pursuant to Rule 144.

 

e)
Representation by the Holder. The Holder, by the acceptance hereof, represents and warrants that it is acquiring this Warrant
and, upon any exercise hereof, will acquire the Warrant Shares issuable upon such exercise, for its own account and not with a
view to or for distributing or reselling such Warrant Shares or any part thereof in violation of the Securities Act or any applicable
state securities law, except pursuant to sales registered or exempted under the Securities Act.

 

Section
4. Miscellaneous.

 

a)
No Rights as Stockholder Until Exercise. This Warrant does not entitle the Holder to any voting rights, dividends or other
rights as a stockholder of the Company prior to the exercise hereof as set forth in Section 1(d)(i), except as expressly set forth
in Section 2.

 

b)
Loss, Theft, Destruction or Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence reasonably
satisfactory to it of the loss, theft, destruction or mutilation of this Warrant or any stock certificate relating to the Warrant
Shares, and in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to it (which, in the case
of the Warrant, shall not include the posting of any bond), and upon surrender and cancellation of such Warrant or stock certificate,
if mutilated, the Company will make and deliver a new Warrant or stock certificate of like tenor and dated as of such cancellation,
in lieu of such Warrant or stock certificate.

 

    	 	 	 

     

    

 

c)
Saturdays, Sundays, Holidays, etc. If the last or appointed day for the taking of any action or the expiration of any right
required or granted herein shall not be a Business Day, then, such action may be taken or such right may be exercised on the next
succeeding Business Day.

 

d)
Authorized Shares.

 

(i)
The Company covenants that during the period the Warrant is outstanding, it will reserve from its authorized and unissued Common
Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights
under this Warrant. The Company further covenants that its issuance of this Warrant shall constitute full authority to its officers
who are charged with the duty of issuing the necessary Warrant Shares upon the exercise of the purchase rights under this Warrant.
The Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may be issued as provided
herein without violation of any applicable law or regulation, or of any requirements of the Trading Market upon which the Common
Stock may be listed. The Company covenants that all Warrant Shares which may be issued upon the exercise of the purchase rights
represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and payment for such Warrant
Shares in accordance herewith, be duly authorized, validly issued, fully paid and nonassessable and free from all taxes, liens
and charges created by the Company in respect of the issue thereof (other than taxes in respect of any transfer occurring contemporaneously
with such issue).

 

(ii)
Except and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation,
amending its certificate of incorporation or through any reorganization, transfer of assets, consolidation, merger, dissolution,
issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms of this Warrant, but will at all times in good faith assist in the carrying out of all such terms and in the taking of all
such actions as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment.
Without limiting the generality of the foregoing, the Company will: (i) not increase the par value of any Warrant Shares above
the amount payable therefor upon such exercise immediately prior to such increase in par value; (ii) take all such action as may
be necessary or appropriate in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares
upon the exercise of this Warrant; and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions
or consents from any public regulatory body having jurisdiction thereof, as may be, necessary to enable the Company to perform
its obligations under this Warrant.

 

(iii)
Before taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable
or in the Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may
be necessary from any public regulatory body or bodies having jurisdiction thereof.

 

e)
Restrictions. The Holder acknowledges that the Warrant Shares acquired upon the exercise of this Warrant, if not registered
and the Holder does not utilize cashless exercise, will have restrictions upon resale imposed by state and federal securities
laws.

 

f)
Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part of Holder
shall operate as a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies, notwithstanding
the fact that all rights hereunder terminate on the Termination Date. If the Company willfully and knowingly fails to comply with
any provision of this Warrant, which results in any material damages to the Holder, the Company shall pay to the Holder such amounts
as shall be sufficient to cover any costs and expenses including, but not limited to, reasonable attorneys’ fees, including
those of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing
any of its rights, powers or remedies hereunder.

 

    	 	 	 

     

    

 

g)
Notices. Any notice, request or other document required or permitted to be given or delivered to the Holder by the Company
shall be delivered in accordance with the notice provisions of the Note pursuant to which this Warrant is issued..

 

h)
Limitation of Liability. No provision hereof, in the absence of any affirmative action by the Holder to exercise this Warrant
to purchase Warrant Shares, and no enumeration herein of the rights or privileges of the Holder, shall give rise to any liability
of the Holder for the purchase price of any Common Stock or as a stockholder of the Company, whether such liability is asserted
by the Company or by creditors of the Company.

 

i)
Remedies. The Holder, in addition to being entitled to exercise all rights granted by law, including recovery of damages,
will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would not
be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and hereby agrees
to waive and not to assert the defense in any action for specific performance that a remedy at law would be adequate.

 

j)
Successors and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations evidenced hereby
shall inure to the benefit of and be binding upon the successors and permitted assigns of the Company and the successors and permitted
assigns of Holder. The provisions of this Warrant are intended to be for the benefit of any Holder from time to time of this Warrant
and shall be enforceable by the Holder or holder of Warrant Shares.

 

k)
Amendment. This Warrant may be modified or amended or the provisions hereof waived with the written consent of the Company
and the Holder.

 

l)
Severability. Wherever possible, each provision of this Warrant shall be interpreted in such manner as to be effective
and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such
provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating the remainder of such provisions
or the remaining provisions of this Warrant.

 

m)
Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose, be
deemed a part of this Warrant.

 

n)
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Warrant shall
be governed by and construed and enforced in accordance with the internal laws of the Commonwealth of Massachusetts, without regard
to the principles of conflict of laws thereof. Each party agrees that all legal proceedings concerning the interpretation, enforcement
and defense of the transactions contemplated by any of the Transaction Documents (whether brought against a party hereto or its
respective Affiliates, directors, officers, shareholders, employees or agents) shall be commenced in the state and federal courts
sitting in the Commonwealth of Massachusetts (the “Massachusetts Courts”). The Holder and the Company each
hereby irrevocably submits to the exclusive jurisdiction of the Massachusetts Courts for the adjudication of any dispute hereunder
or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement
of any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of such Massachusetts Courts, or such Massachusetts Courts are
improper or inconvenient venue for such proceeding. The Holder and the Company each hereby irrevocably waives personal service
of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof via registered
or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under
this Warrant and agrees that such service shall constitute good and sufficient service of process and notice thereof. Nothing
contained herein shall be deemed to limit in any way any right to serve process in any other manner permitted by applicable law.
The Holder and the Company each hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right
to trial by jury in any legal proceeding arising out of or relating to this Warrant or the transactions contemplated hereby. If
any party shall commence an action or proceeding to enforce any provisions of this Warrant, then the prevailing party in such
action or proceeding shall be reimbursed by the other party for its attorneys’ fees and other costs and expenses incurred
in the investigation, preparation and prosecution of such action or proceeding.

 

********************

 

(Signature
Page Follows)

 

    	 	 	 

     

    

 

IN
WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer thereunto duly authorized as of the date first
above indicated.

 

	 	PRESSURE
    BIOSCIENCES, INC.
	 	 	 
	 	By:	         
	 	Name:	 
	 	Title:	 

 

    	 	 	 

     

    

 

NOTICE
OF EXERCISE

 

TO:
PRESSURE BIOSCIENCES, INC.

 

(1)
The undersigned hereby elects to purchase Warrant Shares of the Company pursuant to the terms of the attached Warrant (only if
exercised in full), and tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if
any.

 

(2)
Payment shall take the form of (check applicable box):

 

	 	[  ]
    in lawful money of the United States; or
	 	 
	 	[  ]
    [if permitted the cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth
    in subsection 1(c), to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to
    the cashless exercise procedure set forth in subsection 1(c).

 

(3)
Please issue said Warrant Shares in the name of the undersigned or in such other name as is specified below:

 

The
Warrant Shares shall be delivered to the following DWAC Account Number:

 

	 	 	 
	 	 	 
	 	 	 

 

(4)
Accredited Investor. The undersigned is an “accredited investor” as defined in Regulation D promulgated under
the Securities Act of 1933, as amended.

 

[SIGNATURE
OF HOLDER]

 

	Name of
    Investing Entity:	 	 
	 	 	 
	Signature of Authorized
    Signatory of Investing Entity:	 	 
	 	 	 
	Name of Authorized
    Signatory:	 	 
	 	 	 
	Title of Authorized
    Signatory:	 	 
	 	 	 
	Date: ______________	 	 

 

ASSIGNMENT
FORM

 

(To
assign the foregoing Warrant, execute this form and supply required information. Do not use this form to purchase shares.)

 

	Name:	 	 
	 	(Please
    Print)	 
	Address:	 	 
	 	(Please
    Print)	 

 

	Dated:
    _________	 
	 	 
	Holder’s
    Signature: ________	 
	 	 
	Holder’s
    Address: _________NEITHER
THE ISSUANCE AND SALE OF THE SECURITIES REPRESENTED BY THIS PROMISSORY NOTE NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE
EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES
MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE
SECURITIES UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR (B) AN OPINION OF COUNSEL (WHICH COUNSEL SHALL BE SELECTED BY THE
HOLDER), IN A GENERALLY ACCEPTABLE FORM, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR (II) UNLESS SOLD PURSUANT TO RULE
144 OR RULE 144A UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE MARGIN
ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES.

 

PRESSURE
BIOSCIENCES, inc.

 

PROMISSORY
NOTE

 

	US$2,000,000	Issue
                                         Date: October XX, 2016

 

This
Promissory Note (the “Note”) is duly authorized and issued by PRESSURE
BIOSCIENCES, inc., a corporation incorporated under the laws of the Commonwealth of Massachusetts and located at 14
Norfolk Avenue, South Easton, MA 02375 (the “Company”), in favor of XXXXXXX, an individual residing at XXXXX
(the “Holder”).

 

FOR
VALUE RECEIVED, the Company promises to pay to the order of the Holder the principal sum of Two Million United States Dollars
(US$2,000,000) (the “Principal Amount”) or, if less, the aggregate unpaid principal amount of the Revolver
Advances (as defined below) from time to time outstanding made by the Holder to the Company, by the twelve (12) month anniversary
of the date hereof, or such earlier date, pursuant to Section 3 hereof (the “Maturity Date”), and to pay interest
in an amount equal to the Guaranteed Interest (as defined below) on all outstanding amounts hereunder on or prior to the Maturity
Date, in accordance with the terms hereof.

 

    	 		 

    	 		 

    

 

1.
Principal and Interest.

 

(a)
Revolver Advances. The Company shall request principal advances from time to time prior to the Maturity Date by delivering
an advance request (in the form attached hereto as Exhibit A, each an “Advance Request”) to the Holder.
Within three (3) Business Days of the Holder’s receipt of an Advance Request, the Holder shall advance a principal amount
to Signature Bank acting as escrow agent for the Company equal to the amount requested by the Company on the relevant Advance
Request, provided, however, that (a) the Holder agrees to make the requested principal advance to the Company; (b)
at no time shall the principal amount outstanding hereunder exceed the Principal Amount; (c) the Company shall not request and
the Holder shall not be required to advance more than $250,000 in any individual fifteen (15) day period; and (d) the Company
shall not request and the Holder shall not be required to advance more than $500,000 in the thirty (30) day period immediately
following the date of the initial advance hereunder. Upon advancing any principal amount to the Company pursuant hereto, the Holder
shall endorse the amount and the date of the making of the principal advance hereunder on the grid annexed hereto as Schedule
A and made a part hereof (the “Payment Schedule”), which endorsement shall, absent gross negligence, constitute
evidence of the accuracy of the information so endorsed; provided, however, that any failure to endorse such information
on the Payment Schedule shall not in any manner affect the obligation of the Company to make payment of principal and interest
in accordance with the terms of this Note. The release of funds shall be determined by the receipt of an executed Advance Request
by the Company and the Investor (“Closing Conditions”). Once Closing Conditions have been satisfied, the Company
and Garden State Securities, Inc. will instruct the escrow agent to release funds from escrow.

 

(b)
Payment of Principal. The principal amount of this Note shall be paid in full on the Maturity Date, unless otherwise paid
prior to the Maturity Date, at the option of the Company.

 

(c)
Payment of Interest. Interest on the principal balance of this Note shall paid in full on the Maturity Date, unless otherwise
paid prior to the Maturity Date, at the option of the Company. With the exception of Default Interest, interest shall be in the
form of one-time interest charges assessed in full as of the date of the principal advance and shall not be assessed per annum.
The amount of interest which shall be assessed with respect to any principal advance shall be determined as follows (the “Guaranteed
Interest”):

 

	 	i.	one-time
    interest charge of ten percent (10%) on all principal amounts advanced on or prior to the six (6) month anniversary of the
    date hereof (such date, the “Trigger Date”);
	 	 	 
	 	ii.	one-time
    interest charge of ten percent (10%) on (1) all principal amounts advanced following the Trigger Date and prior to the nine
    (9) month anniversary of the date hereof and, (2) with respect to any amounts which have been previously advanced prior to
    the Trigger Date and remain outstanding as of the Trigger Date, four percent (4%) on all such outstanding principal amounts,
    as determined to be outstanding as of the Trigger Date; and
	 	 	 
	 	iii.	one-time
    interest charge of ten percent (10%) on (1) all principal amounts advanced following the nine (9) month anniversary of the
    date hereof and prior to the Maturity Date and, (2) with respect to any amounts which have been previously advanced prior
    to the nine (9) month anniversary of the date hereof and remain outstanding as of the nine (9) month anniversary of the date
    hereof, four percent (4%) on all such outstanding principal amounts, as determined to be outstanding as of the nine (9) month
    anniversary of the date hereof.

 

    	 	2	 

    	 		 

    

 

(d)
Payment of Default Interest. Any amount of principal or interest on this Note which is not paid when due shall bear interest
at the rate of twenty percent (20%) per annum (the “Default Rate”) until such past due amount is paid.

 

(e)
General Payment Provisions. All payments of principal and interest on this Note shall be made in lawful money of the United
States of America by check or wire transfer to such account as the Holder or the Company (as applicable) may designate. Whenever
any amount expressed to be due by the terms of this Note is due on any day which is not a Business Day, the same shall instead
be due on the next succeeding Business Day. For purposes of this Note, “Business Day” shall mean any day other
than a Saturday, Sunday or a day on which commercial banks in the State of New York are authorized or required by law or executive
order to remain closed.

 

2.
Repayments/Prepayments/Re-Borrowing. The Company may from time to time, repay or prepay the outstanding balance owed pursuant
to this Note, in whole or in part, without penalty. The Holder shall endorse the amount and the date of any repayment or prepayment
on the Payment Schedule, which endorsement shall, absent gross negligence, constitute evidence of the accuracy of the information
so endorsed; provided, however, that any failure to endorse such information on the Payment Schedule shall not in
any manner affect the obligation of the Borrower to make payment of principal and interest in accordance with the terms of this
Note. Any amount repaid or prepaid hereunder may be re-borrowed at the option of the Company.

 

3.
Acceleration of Maturity Date. In the event that the Company completes a Qualified Offering, the Company shall repay any
and all amounts owing to the Holder pursuant hereto within seven (7) Business Days of the closing date of such Qualified Offering.
“Qualified Offering” means the completion of a public offering of the Company’s securities pursuant to
which the Company receives aggregate gross proceeds of at least Seven Million United States Dollars (US$7,000,000) in consideration
of the purchase of its securities and resulting in, pursuant to the effectiveness of the registration statement for such offering,
the Company’s common stock being traded on the NASDAQ Capital Market, NASDAQ Global Select Market or the New York Stock
Exchange. 

 

4.
Qualified Offering. While any principal or interest remains outstanding hereunder, the Holder has the right to convert
all or any portion of the outstanding principal or interest into common stock of the Company on the same terms and for the same
purchase price as the Company has offered, and third party investors have accepted, in connection with the Qualified Offering.

 

    	 	3	 

    	 		 

    

 

5.
Origination Fee. In consideration of the Holder agreeing to provide the financing contemplated hereby and advancing the
principal amounts which the Holder has agreed to advance hereunder at the request of the Company, in addition to any other fees
or amounts payable by the Company pursuant to this Note, the Company shall pay both a Cash/Stock Fee and a Warrant Fee, as follows:

 

	 	(a)	Cash/Stock
    Fee.

 

	 	i.	in
    the event that a Qualified Offering occurs on or prior to the Trigger Date, within seven (7) Business Days of the closing
    of the Qualified Offering, the Company shall pay a cash fee equal to five percent (5%) of the total outstanding amount owed
    by the Company to the Holder as of the closing date of the Qualified Offering or, at the option of the Company, issue to the
    Holder a number of restricted shares of the Company’s common stock equal to (x) five percent (5%) of the total outstanding
    amount owed by the Company to the Holder as of the closing date of the Qualified Offering divided by (y) the purchase
    price provided by the documents governing the Qualified Offering; or
	 	 	 
	 	ii.	in
    the event that a Qualified Offering does
    not occur on or prior to the Trigger Date, within seven (7) Business Days of the Trigger
    Date, the Company shall pay a cash fee equal to five percent (5%) of the total outstanding amount owed by the Company to the
    Holder as of the Trigger Date or, at the option of the Company, the Company shall issue to the Holder a number of restricted
    shares of the Company’s common stock equal to (x) five percent (5%) of the total outstanding amount owed by the Company
    to the Holder as of the Trigger Date divided by (y) the VWAP of the Company’s common stock for the last ten (10)
    Trading Days preceding the Trigger Date. 

 

	 	(b)	Warrant
    Fee. Within seven business days of the date upon which the Holder makes a principal advance to the Company in accordance
    with Section 1 herein, the Company shall issue to the Holder a common stock purchase warrant (in the form attached hereto
    as Exhibit B), pursuant to which the Holder shall be permitted to purchase that certain number of shares of the Company’s
    common stock equal to (x) one hundred percent (100%) of such principal amount advanced at such time divided by (y)
    forty cents ($0.40) with an exercise price of forty cents ($0.40) (the “Exercise Price”).

 

    	 	4	 

    	 		 

    

 

6.
Trigger Date Fee. In the event that any principal or interest remains outstanding on the first Business Day following the
Trigger Date, the Company shall pay a Cash/Stock Fee, as follows: 

 

	 	(a)	Cash/Stock
    Fee.

 

	 	i.	in
    the event that a Qualified Offering occurs following the Trigger Date but on or prior to the Maturity Date, within seven (7)
    Business Days of the closing of the Qualified Offering, the Company shall pay a cash fee equal to five percent (5%) of the
    total outstanding amount owed by the Company to the Holder as of the closing date of the Qualified Offering or, at the option
    of the Company, issue to the Holder a number of restricted shares of the Company’s common stock equal to (x) five percent
    (5%) of the total outstanding amount owed by the Company to the Holder as of the closing date of the Qualified Offering divided
    by (y) the purchase price provided by the documents governing the Qualified Offering; or
	 	 	 
	 	ii.	in
    the event that a Qualified Offering does
    not occur following the Trigger Date or prior to the Maturity Date, on the Maturity Date,
    the Company shall pay a cash fee equal to five percent (5%) of the total outstanding amount owed by the Company to the Holder
    or, at the option of the Company, the Company shall issue to the Holder a number of restricted shares of the Company’s
    common stock equal to (x) five percent (5%) of the total outstanding amount owed by the Company to the Holder as of the Maturity
    Date divided by (y) the VWAP of the Company’s common stock for the last ten (10) Trading Days preceding the Maturity
    Date.

 

	 	(b)	Definitions.
    For purposes of this Note, “VWAP” means, for any date, the volume-weighted average price of the common
    stock on the Principal Market for a particular Trading Day or set of Trading Days, as the case may be, as reported by Bloomberg.
    “Trading Day” means any day during which the principal market on which the common stock is traded (the
    “Principal Market”) shall be open for business. Any amounts to be paid in cash, as provided in this Section,
    may be added to the principal balance of this Note, as the option of the Company.

 

7.
Holder Representations and Warranties. Holder hereby represents, warrants and agrees with the Company that:

 

(a)
Standing of Holder. Holder has the legal capacity and power to enter into this Note.

 

(b)
Authorization and Power. Holder has the requisite power and authority to enter into and perform this Note and to advance
the principal amount provide hereunder and accept the Note. The execution, delivery and performance of this Note by Holder, and
the consummation by Holder of the transactions contemplated hereby, have been duly authorized by all necessary action, and no
further consent or authorization of Holder is required. This Note has been duly authorized, executed and delivered by Holder and
constitutes, or shall constitute, when executed and delivered, a valid and binding obligation of Holder, enforceable against Holder
in accordance with the terms hereof.

 

    	 	5	 

    	 		 

    

 

(c)
Information on Holder. Holder is an “accredited investor,” as such term is defined in Regulation D promulgated
by the Commission under the 1933 Act, is experienced in investments and business matters, has made investments of a speculative
nature and has purchased securities of United States publicly-owned companies in private placements in the past and, with Holder’s
representatives, has such knowledge and experience in financial, tax and other business matters as to enable Holder to utilize
the information made available by the Company to evaluate the merits and risks of, and to make an informed investment decision
with respect to, the proposed purchase, which Holder hereby agrees represents a speculative investment. Holder has the authority
and is duly and legally qualified to purchase and own the Note. Holder is able to bear the risk of such investment for an indefinite
period and to afford a complete loss thereof.

 

(d)
Purchase of Note. Holder will purchase the Note for Holder’s own account for investment and not with a view toward,
or for resale in connection with, the public sale or any distribution thereof in violation of the Securities Act of 1933, as amended
(the “Securities Act”) or any applicable state securities law, and has no direct or indirect arrangement or
understandings with any other person or entity to distribute or regarding the distribution of the Note.

 

(e)
Highly Speculative Investment. Holder acknowledges and agrees that a purchase of the Note is highly speculative and involves
significant risks and that the Note should not be purchased if Holder cannot afford the loss of Holder’s entire investment.
The business objectives of the Company are speculative, and it is possible that the Company may be unable to achieve them. Holder
understands that Holder may be unable to realize a substantial return on the purchase of the offered Note, or any return whatsoever,
and may lose Holder’s entire investment.

 

(f)
Compliance with Securities Act. Holder understands and agrees that the Note has not been registered under the Securities
Act or any applicable state securities laws by reason of their issuance in a transaction that does not require registration under
the Securities Act (based in part on the accuracy of the representations and warranties of Holder contained herein).

 

(g)
Communication of Offer. Holder has a preexisting personal or business relationship with the Company or one or more of its
directors, officers, advisors or control persons, and the offer to issue the Note was directly communicated to Holder by the Company.
At no time was Holder presented with or solicited by any leaflet, newspaper or magazine article, radio or television advertisement,
or any other form of general advertising or solicited or invited to attend a promotional meeting otherwise than in connection
and concurrently with such communicated offer.

 

(h)
No Governmental Endorsement. Holder understands that no United States federal or state agency or any other governmental
or state agency has passed on or made recommendations or endorsement of the Note, or the suitability of the investment in the
Note, nor have such authorities passed upon or endorsed the merits of the offering of the Note.

 

(i)
Information. Holder and its advisors, if any, have been furnished with all materials relating to the business, finances
and operations of the Company and materials relating to the offer and sale of the Note that have been requested by Holder. Holder
and its advisors, if any, have been afforded the opportunity to ask questions of the Company. Neither such inquiries nor any other
due diligence investigations conducted by Holder or its advisors, if any, or its representatives shall modify, amend or affect
Holder’s right to rely on the Company’s representations and warranties contained herein. Holder understands that its
investment in the Note involves a high degree of risk and the Holder is able to afford a complete loss of such investment. Holder
has sought such accounting, legal and tax advice as it has considered necessary to make an informed investment decision with respect
to its acquisition of the Note.

 

    	 	6	 

    	 		 

    

 

(j)
Reliance on Exemptions. The Holder understands that the Note is being offered and sold or assigned to it in reliance on
specific exemptions from the registration requirements of United States federal and state securities laws and that the Company
is relying in part upon the truth and accuracy of, and Holder’s compliance with, the representations, warranties, agreements,
acknowledgments and understandings of Holder set forth herein in order to determine the availability of such exemptions and the
eligibility of Holder to acquire the Note.

 

8.
Company Representations and Warranties. The Company represents, warrants and agrees with Holder that:

 

(a)
Due Incorporation. The Company is a corporation duly incorporated, validly existing and in good standing under the laws
of the jurisdiction of its incorporation;

 

(b)
Authority; Enforceability. This Note has been duly authorized, executed and delivered by the Company and is the valid and
binding agreement of the Company, enforceable in accordance with their terms, except as may be limited by bankruptcy, insolvency,
moratorium or other similar laws affecting the enforcement of creditors’ rights generally, or principles of equity. The
Company has full corporate power and authority necessary to enter into and deliver this Note and to perform its obligations thereunder;

 

(c)
Encumbrances. Upon issuance, the Note (i) shall be free and clear of any security interests, liens, claims or other encumbrances;
(ii) shall have been duly and validly issued, fully paid and non-assessable; and (iii) will not subject the holders thereof to
personal liability by reason of being such holders;

 

(d)
Litigation. There is no pending or, to the knowledge of the Company, threatened action, suit, proceeding or investigation
before or by any court, governmental agency or body having jurisdiction over the Company including, without limitation, any such
that would materially affect the execution by the Company or the complete and timely performance by the Company of its obligations
under this Note;

 

(e)
No General Solicitation. Neither the Company, nor any of its affiliates, nor any person or entity acting on its or their
behalf, has engaged in any form of general solicitation or general advertising (within the meaning of Regulation D under the Securities
Act) in connection with the offer or sale of the Note;

 

(f)
Investment Company. The Company is not an “investment company” within the meaning of the Investment Company
Act of 1940, as amended; and

 

(g)
Full Disclosure. No representation or warranty or other statement made by the Company in this Note in connection with the
contemplated transactions contains any untrue statement of material fact or omits to state a material fact necessary to make the
representations and warranties set forth herein, in light of the circumstances in which they were made, not misleading.

 

    	 	7	 

    	 		 

    

 

9.
Broker’s Commission/Finder’s Fee. With the exception of Garden State Securities, Inc. which is being paid eight
percent (8%) of all principal amounts advanced in connection herewith, there are no parties entitled to receive fees, commissions,
finder’s fees, due diligence fees or similar payments in connection with the consummation of the transactions contemplated
hereby. Each party hereto agrees to indemnify the other against and hold the other harmless from any and all liabilities to any
persons claiming brokerage commissions or similar fees on account of services purported to have been rendered on behalf of the
indemnifying party in connection with this Note or the transactions contemplated hereby and arising out of the indemnifying party’s
actions.

 

10.
Events of Default. The term “Event of Default” shall mean any of the events set forth in this Section
(the term “Company” for this purpose shall include all subsidiaries of the Company):

 

(a)
Non-Payment of Obligations. The Company shall default in the payment of the Principal Amount of, or accrued but unpaid
interest on, this Note as and when the same shall become due and payable, whether by acceleration or otherwise, and the Holder
shall have delivered written notice to the Company and provided a fifteen (15) day opportunity to cure such default.

 

(b)
Non-Performance of Covenants. The Company shall default in the due observance or performance of any covenant set forth
herein, which default shall continue uncured for ten (10) days after notice thereof.

 

(c)
Bankruptcy, Insolvency, etc. The Company shall (i) apply for, consent to, or acquiesce in, the appointment of a trustee,
receiver, sequestrator or other custodian for the Company or any of its property, or make a general assignment for the benefit
of creditors; (ii) in the absence of such application, consent or acquiesce in, permit or suffer to exist the appointment of a
trustee, receiver, sequestrator or other custodian for the Company or for any part of its property and that is not dismissed within
sixty (60) days; or (iii) take any corporate or other action authorizing any of the foregoing.

 

11.
Remedies. If any Event of Default shall occur for any reason, whether voluntary or involuntary, the Holder may, upon expiration
of any stated grace period (if any) and upon written notice to the Company, declare all or any portion of the outstanding principal
amount of the Note and all accrued but interest thereon, to be due and payable and any or all other obligations hereunder to be
due and payable, whereupon the full unpaid principal amount hereof, and any and all other such obligations which shall be so declared
due and payable shall be and become immediately due and payable, without further notice, demand, or presentment. The Holder shall
have all rights available to it at law or in equity.

 

    	 	8	 

    	 		 

    

 

12.
Default Interest; Miscellaneous. If any Event of Default shall occur, the Principal Amount of this Note, all accrued but
unpaid interest thereon, and all other obligations hereunder shall accrue interest at the Default Rate. The Holder may assess
reasonable attorneys’ fees, paralegals’ fees and costs and expenses incurred or anticipated by the Holder in collecting
or enforcing payment hereof (whether such fees, costs or expenses are incurred in negotiations, all trial and appellate levels,
administrative proceedings, bankruptcy proceedings or otherwise), and together with all other sums due by the Company hereunder,
all without any relief whatsoever from any valuation or appraisement laws, and payment thereof may be enforced and recovered in
whole or in part at any time by one or more of the remedies provided to the Holder at law, in equity, or under this Note. In connection
with the Holder’s rights hereunder upon an Event of Default, the Holder need not provide, and the Company hereby waives,
any presentment, demand, protest or other notice of any kind, and the Holder may immediately enforce any and all of its rights
and remedies hereunder and all other remedies available to it in equity or under applicable law.

 

13.
Miscellaneous.

 

(a)
Parties in Interest. All covenants, agreements and undertakings in this Note binding upon the Company or the Holder shall
bind and inure to the benefit of the successors and permitted assigns of the Company and the Holder, respectively, whether so
expressed or not.

 

(b)
Law Governing this Note. This Note shall be governed by the laws of the State of Illinois without regard to any principles
of conflicts of law. Each of the parties hereby irrevocably consents and agrees that any legal or equitable action or proceeding
arising under or in connection with this Note shall be brought in the federal or state courts located in Illinois, and by execution
and delivery of this Note, irrevocably submits to and accepts the jurisdiction of said courts, waives any defense that such court
is not a convenient forum, and consent to any service of process method permitted by law.

 

(c)
Waiver of Jury Trial. THE PARTIES HEREBY KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVE ANY RIGHTS THEY MAY HAVE TO
A TRIAL BY JURY IN RESPECT OF ANY LITIGATION BASED HEREON, OR ARISING OUT OF, UNDER, OR IN CONNECTION WITH, THIS NOTE OR ANY OTHER
DOCUMENT OR INSTRUMENT EXECUTED AND DELIVERED IN CONNECTION HEREWITH, OR ANY COURSE OF CONDUCT, COURSE OF DEALING, STATEMENTS
(WHETHER VERBAL OR WRITTEN), OR ACTIONS OF THE HOLDER OR THE COMPANY. THIS PROVISION IS A MATERIAL INDUCEMENT FOR THE HOLDER’S
PURCHASING THIS NOTE.

 

    	 	9	 

    	 		 

    

 

(d)
Notices. All notices, demands, requests, consents, approvals, and other communications required or permitted hereunder
shall be in writing and, unless otherwise specified herein, shall be (i) personally served, (ii) deposited in the mail, registered
or certified, return receipt requested, postage prepaid, (iii) delivered by reputable air courier service with charges prepaid,
or (iv) transmitted by hand delivery or facsimile, addressed as set forth in the preamble paragraph hereto or to such other address
as such party shall have specified most recently by written notice. Any notice or other communication required or permitted to
be given hereunder shall be deemed effective (a) upon hand delivery at the address designated in the preamble paragraph hereto
(if delivered on a business day during normal business hours where such notice is to be received), or the first business day following
such delivery (if delivered other than on a business day during normal business hours where such notice is to be received) or
(b) on the second business day following the date of mailing by express courier service, fully prepaid, addressed to such address,
or upon actual receipt of such mailing, whichever shall first occur.

 

(e)
No Waiver. No delay in exercising any right hereunder shall be deemed a waiver thereof, and no waiver shall be deemed to
have any application to any future default or exercise of rights hereunder.

 

(f)
Modification and Severability. If, in any action before any court or agency legally empowered to enforce any provision
contained herein, any provision hereof is found to be unenforceable, then such provision shall be deemed modified to the extent
necessary to make it enforceable by such court or agency. If any such provision is not enforceable as set forth in the preceding
sentence, the unenforceability of such provision shall not affect the other provisions of this Note, but this Note shall be construed
as if such unenforceable provision had never been contained herein.

 

(g)
Entire Agreement. This Note constitutes the entire agreement between the parties hereto with respect to the subject matter
hereof and may be amended only by a writing executed by both parties hereto. Neither the Company nor Holder has relied on any
representations not contained or referred to in this Note and the documents delivered herewith.

 

(h)
Counterparts/Execution. This Note may be executed in any number of counterparts and by the different signatories hereto
on separate counterparts, each of which, when so executed, shall be deemed an original, but all such counterparts shall constitute
but one and the same instrument. This Note may be executed by facsimile transmission, PDF, electronic signature or other similar
electronic means with the same force and effect as if such signature page were an original thereof.

 

(i)
Severability. In the event that any provision of this Note or any other agreement delivered in connection herewith is invalid
or unenforceable under any applicable statute or rule of law, then such provision shall be deemed inoperative to the extent that
it may conflict therewith and shall be deemed modified to conform with such statute or rule of law. Any such provision which may
prove invalid or unenforceable under any law shall not affect the validity or enforceability of any other provision of any agreement.

 

(j)
Counsel; Ambiguities. Each party and its counsel have participated fully in the review and revision of this Note and any
documents executed in connection therewith. The parties understand and agree that any rule of construction to the effect that
ambiguities are to be resolved against the drafting party shall not apply in interpreting this Note and any documents executed
in connection therewith. The language in this Note and any documents executed in connection therewith shall be interpreted as
to its fair meaning and not strictly for or against any party.

 

(k)
Captions. The captions of the various sections and paragraphs of this Note have been inserted only for the purposes of
convenience; such captions are not a part of this Note and shall not be deemed in any manner to modify, explain, enlarge or restrict
any of the provisions of this Note.

 

[Signature
page follows]

 

    	 	10	 

    	 		 

    

 

IN
WITNESS WHEREOF, this Note has been executed and delivered on the date specified above.

 

	 	COMPANY:
	 	 
	 	PRESSURE
    BIOSCIENCES, INC.
	 	 	 
	 	By:	 
	 	Name:	Richard
    T. Schumacher
	 	Title:	President
    and CEO
	 	 	 
	 	HOLDER:
	 	 
	 	 
	 	Investor

 

[signature
page to Promissory Note]

 

    	 	11	 

    	 		 

    

 

SCHEDULE
A

PAYMENT
SCHEDULE

 

	Date
    of	 	Amount
    of	 	Amount
    of	 	Unpaid
	Principal	 	Principal	 	Interest	 	Principal
	Payment
    / Repayment	 	Payment
    / Repayment	 	Paid	 	Balance
	 	 	 	 	 	 	 
	 	 	 	 	 	 	 
	 	 	 	 	 	 	 

 

    	 	12	 

    	 		 

    

 

EXHIBIT
A

ADVANCE
REQUEST

 

[HOLDER]

 

Date:
____________

 

Ladies
and Gentlemen:

 

Reference
is made to the Promissory Note, dated October XX, 2016 (the “Note”), by and between Pressure BioSciences, Inc.,
a corporation incorporated under the laws of the State of Massachusetts (the “Company”), and Investor, residing
at XXXXX (the “Holder”). Terms defined in the Note are used herein with the same meanings.

 

The
undersigned hereby gives you notice pursuant to the Note that it requests a principal advance, and in connection therewith, hereby
sets forth below the terms on which such principal advance is requested to be made:

 

	(A)
    Date of advance request 	 	_______________________
	(which
    shall be a Business Day 	 	 
	three
    days from the date hereof) 	 	 
	 	 	 
	(B)
    Principal Amount of Borrowing	 	_______________________
	 	 	 
	(C)
    Wire Instructions for Deposit Account	 	Bank
    Name: _________________________
	 	 	 
	 	 	Routing:
    ____________________________
	 	 	 
	 	 	Account
    Name: _______________________
	 	 	 
	 	 	Account
    Number: _____________________

 

	PRESSURE
    BIOSCIENCES, INC.	 
	 	 	 
	By:	                            	 
	Name:
    	 	 
	Title:
    	 	 

 

    	 	13	 

    	 		 

    

 

EXHIBIT
B

FORM
OF COMMON STOCK PURCHASE WARRANT

 

(see
attached)

 

    	 	14

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