Document:

Lease Agreement, dated December 22, 1004

 Exhibit 10.21 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange
Commission. 
 Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406. 

English Translation for Convenience 
 LEASE AGREEMENT 
 for rented commercial premises 

Between 
 Alters- und
Hinterbliebenen-Versorgungsstelle der 
 Technischen Überwachungsvereine VVaG 
 Kurfürstenstraße 58 
 45138 Essen 

- Lessor - 
 UST (turnover tax) ID: DE11 98
24807 
 and 
 Business name

 Nitec Pharma GmbH 
 - Lessee -

 UST (turnover tax) ID: 37009/52183 

the following agreement will be concluded: 

 LEASE AGREEMENT FOR OFFICE AND 

ADMINISTRATION SPACE 
 CONTENT and ANNEXES 
  

					
	 Page
	  	 Content

		
	1	  	Table of contents
			
	3	  	§1	  	 Leased Object

	3	  	§2	  	 Use of Leased Object

			
	4	  	§3	  	 Furnishing of the Rental Space

	4	  	§4	  	 Length of Lease, Termination

			
	5	  	§5	  	 Rent

			
	6	  	§6	  	 Turnover Tax

	6	  	§7	  	 Changes to Rent

			
	7	  	§8	  	 Payment of Rent

	7	  	§9	  	 Transfer and Condition of Leased Object

	7	  	§10	  	 Use by Third Parties

			
	8	  	§11	  	 Maintenance and Repair

	8	  	§12	  	 Insurance

			
	 8
	  	§13	  	 Signage/Advertising Property

	9	  	§14	  	 Surveillance and Security Systems

			
	 9
	  	§15	  	 Defects to Leased Object/Counterclaims

	 9
	  	§16	  	 Modifications to Leased Object Made by the Lessee

	 9
	  	§17	  	 Modifications to Leased Object Made by the Lessor

	1	  		  	
	 10
	  	§18	  	 Accessing and Entering the Leased Object

	 10
	  	§19	  	 Lessor's Lien/Provision of Security

			
	 11
	  	§20	  	 Termination of Lease

			
	 12
	  	§21	  	 Miscellaneous

			
	Annex I	  		  	 List of Operating Expenses and Service Charges

			
	Annex II	  		  	 Ground Plans of the Rental Space

 § 1 - Leased Object 

 

	1.1	The Lessor is the owner of the property, Joseph-Meyer-Straße 13-15, 68167 Mannheim, Germany. 

 

	1.2	 The Lessor shall lease office space totalling 171.18 sqm. on the 2nd floor of the building described above to the Lessee. This includes main floor
space and ancillary space and the associated public thoroughfares and floor space occupied by technical and building service installations. 

 The enclosed site plan is part of the Lease Agreement (Annex II). 
  

	1.3	If subsequent measurements of the rental space deviate from the floor space provided here, neither Party has the right to rescind this Agreement, to terminate this
Agreement or to demand a change in rent. The floor space indicated is to be taken as the basis whenever the size of the rental space is referred to in the provisions of this Agreement. 

 

	1.4	The space is being rented for use as an office. 

 Any changes in this type of use are only permissible upon obtaining written permission from the Lessor. In all cases, permission given by the Lessor shall be granted subject to first obtaining a required
official permit to change the type of use, even if the Lessor does not remind the Lessee of the need to do this at that time. The Lessee must acquire this permit at his own expense and present it to the Lessor. 

§ 2 - Use of Leased Object 
  

	2.1	The leased object shall be leased by the Lessee for the type of use specified in item 1.4. 

 

	2.2	The Lessor does not guarantee that the business the Lessee plans to conduct in the leased object is permissible according to public law. The Lessee must fulfill
numerous criteria at his own expense in relation to the conduct of his business for the duration of lease. The Lessee must comply with requirements imposed by the trade supervisory office or other authorities and do so regarding space-related
requirements as well. 

 The validity of this Lease Agreement is not contingent on an official permit permitting
the lessee’s business activities. 
  

	2.3	The Lessee undertakes to actively conduct his business and keep it open and operating in accordance with the type of business being conducted (contractual operation to
use, open or operate) for the duration of this Agreement. 

  

	2.4	The Lessor shall not grant the Lessee any protection against competition. 

 

 Page 3 of the Lease Agreement of December 21, 2004 

	2.5	The Lessee shall ask the Lessor for information about the load limit of the ceilings and obtain the Lessor's written approval before setting up machines, heavy objects
or other equipment in the rental space. The Lessee shall be liable for any damages that occur because of failure to comply with these provisions. If the Lessee's equipment as described above causes damage to the building (shaking, cracks, etc.) or
disturbances or has detrimental effects (e.g., noise, dust, disturbing smells, etc.) for other lessees of the building, the Lessor may revoke his approval and demand that the Lessee refrain from these activities. 

 

	2.6	Lease of the object shall include the right of free access to the leased object. 

 § 3 - Furnishing and Transfer of the Rental Space by the Lessor 
  

	3.1	The Lessee is aware of the current condition and layout of the leased object. 

 

	3.2	The leased object will be handed over to the Lessee by January 2005 at the latest. A record shall be made of the transfer. 

§ 4 - Length of Lease and Termination 
  

	4.1	Tenancy shall begin on January 1, 2005, and terminate after 1.5 years on June 30, 2006. section 568 of the German Civil Code (BGB) does not apply to the
Contracting Parties once tenancy has been terminated. 

  

	4.2	Ordinary notice of termination shall be excluded for the duration of tenancy. The right of both Parties to immediate termination without notice for good cause shall
remain unaffected. The right of the Lessor to effect immediate termination without notice applies particularly when: 

  

	 	a)	the Lessee is behind by more than one month's rent or has not provided the security agreed to in the amount, period of time and means stipulated in the Agreement;

  

	 	b)	the Lessee makes structural changes to the leased object or to parts thereof without first obtaining the Lessor's permission or uses it for purposes other than those
stipulated in the Agreement, in particular subletting it to third parties; 

  

	 	c)	the Lessee ceases payment, it comes to legal or out-of-court settlement or bankruptcy proceedings regarding his assets or he is required to make an oath regarding his
assets; 

  

 Page 4 of the Lease Agreement of December 21, 2004 

	 	d)	if the Lessee fails to comply with the terms of contract despite two written warnings regarding the same. 

 

	4.3	The Lessee has the option to extend the Lease Agreement by one, two or three years once the term of the Lease Agreement as specified under item 4.1 has expired. If the
Lessee chooses to exercise this option, he shall notify the Lessor of this decision in writing 6 months prior to expiration of tenancy. The Agreement shall be terminated 6 months prior to the relevant date of expiration. 

 

	4.5	If the Lessee is a natural person, the right of early termination pursuant to section 569 of the German Civil Code (BGB) shall hereby be excluded.

 § 5 - Rent 
  

	5.1	Rent for the basic leasing period from January 1, 2005, until June 30, 2006, shall be calculated as follows: 

 

									
	 Office space
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
	 3 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	171.18 sqm	  	X	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Subtotal, net
	  		  		  		  	[...***...]
	 16 % value-added tax
	  		  		  		  	[...***...]
		  		  		  		  	 
					
	 Gross total
	  		  		  		  	[...***...]
		  		  		  		  	 

 If the Lessee decides to exercise the option stipulated
in item 4 for one year, the rent in the amount of [...***...] shall remain the same. For a two-year duration, rent shall be reduced to [...***...] per sqm and to [...***...] per sqm for a duration of three years. 

 

	5.2	In addition to basic rent, the Lessee shall pay all operating expenses for the leased object that are attributed directly to him (e. g., electricity, gas, water,
telephone and other communications expenses) as well as all of the building operating expenses and service charges. Operating expenses and service charges comprise all costs listed in Annex I of this Agreement as well as any costs that may
arise in the future, having been newly introduced for the leased object by law, regulation, by-law or for any other reason. The list of operating expenses and service charges pursuant to Annex I is therefore an example and not a final listing of all
possible costs. 

  

	5.3	The Lessor shall apportion these operating expenses and service charges to the Lessee and settle these with him. If there are several lessees in the building, the
Lessor shall determine how these costs should be distributed (distribution legend) to the extent he is required to do so by legal provisions and shall do so in accordance with these provisions. The distribution legend shall be based on the share of
leased space from the total area. 

  

 Page 5 of the Lease Agreement of December 21, 2004 

 

			
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	5.4	The Lessor shall invoice these expenses annually by December 15th of the following year at the latest. Should tenancy end during a billing period, the expenses
shall be invoiced within the scope of the following annual accounting activities. 

  

	5.5	If operating costs increase or can be reasonably expected to increase (e. g., due to notification of an increase in local charges), the Lessor has the right to demand a
corresponding increase in the advance payments. 

 § 6 - Turnover Tax 

 

	6.1	In addition to the stipulated basic rent including operating expenses and service charges, the Lessor shall pay turnover tax as it falls due as prescribed under law.
The Lessee guarantees that he intends to use the rental space exclusively for generating turnover which does not exclude the Lessor from deducting input tax. If the Lessee does not use the rental space exclusively to generate profit that does not
exclude input tax deduction as promised (use having negative tax effects), basic rent including service charges shall increase for the period of use having negative tax effects by whichever amount is equal to the basic rent plus operating expenses
and service charges for the turnover tax paid. 

  

	6:2	Upon the Lessor's request, the Lessee shall provide proof that he is using the leased object solely to generate profit that does not exclude input tax deduction. The
Lessee shall immediately inform the Lessor before he starts using the leased object for use having negative tax effects and compensate the Lessor for any damage that may arise due to the Lessee violating his obligation to give notice; this
particularly includes damage caused to the Lessor by paying turnover tax to the internal revenue service after the leased object has begun to be used for purposes having negative tax effects, even though lease of the object is at that time no longer
subject to turnover tax. Claims for damages of this nature shall not become statute-barred until 6 months after a tax authority or tax court has determined that the Lessor does not or no longer has the right to input tax deduction.

 § 7 - Changes to Rent 
  

	7.1.	If the price index determined by the German Federal Statistics Office for the standard of living for all private households (consumer price index for Germany) (base
year 2000 = 100 points) changes as compared to its state as of June 30, 2009, or as compared to the last adjustment of rent by more than [...***...], the basic rent stipulated in item 5 shall be proportionally modified accordingly.
Changes shall become effective on the first day of the month in which the change has been made. 

  

 Page 6 of the Lease Agreement of December 21, 2004 

 

			
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	7.2.	 If this adjustment clause cannot be considered approved pursuant to item 4 of the price clause decree, the Parties undertake to agree on an adjustment
clause that comes as close as possible to the commercial concept and purpose of the original clause which can be approved according to the provisions valid at that time. 

 § 8 - Payment of Rent 
 Payment of rent shall begin on January 1,
2005. 
 Rent is due by the 3rd business day of each month at the latest and shall be paid to the following account:
[...***...]. 
 § 9 - Transfer of Leased Object / Condition of Leased Object 

 

	9.1	Transfer of the leased object is scheduled to take place at the start of the rental period pursuant to item 4.1. The Lessor shall notify the Lessee of the official
transfer date in writing as soon as possible. 

 Any work that still needs to be done, e. g., complete provision of
outdoor facilities and/or repair of defects, shall not prevent transfer of the leased object. 
  

	9.2	The Parties shall make a record of the transfer at the time of transfer documenting the condition of the leased object as well as any defects present at that time.

 The Lessor shall repair any defects identified in the record of transfer within a reasonable amount of time.

 § 10 - Use by Third Parties 
  

	10.1	Any partial or complete use by third parties, particularly subletting the leased object, requires the Lessor’s prior consent. The Lessee shall not have the right
to terminate the lease should the Lessor not give his consent. The Lessee shall be responsible for and bear the costs of meeting any conditions stipulated by the authorities within the scope of such transfer of use so that the leased object can be
used for other purposes that have been approved by the Lessor. 

  

	10.1	The Lessor may revoke his approval of a subletting arrangement for good cause. However, this may not be done at an inopportune time. 

 

 Page 7 of the Lease Agreement of December 21, 2004 

 

			
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 § 11 - Maintenance/Repairs/Decorative Repairs/Liability for Damages 

 

	11.1	The Lessee shall be responsible for decorative repairs as well as other maintenance and repair work inside the rental space as well as any damage caused by lessee use
(wear and tear, deterioration, damage caused by the Lessee or his helpers). 

 §12 - Insurance 

 

	12.1	Standard building insurance (fire, storm, damage from mains water, extended coverage) and premises liability insurance shall be concluded by the Lessor and billed
together with the operating expenses and service charges. The installation of any fixtures in or additions or renovations to the leased object conducted by the Lessee shall not be covered by the building insurance. The Lessee shall be obliged to
obtain insurance for these fixtures, additions or renovations at his own cost. 

  

	12.2	The Lessee shall be obliged to obtain sufficient business liability insurance as well as insurance covering breaking and entering as well as theft and sufficient
insurance against any damage to equipment and objects brought into the leased object at his own expense and to maintain these insurance policies for the length of the lease. 

 

	12.3	The Lessor has the right to view the insurance contracts as proof that the Lessee has obtained the insurance policies listed under item 12.2 and that these are being
maintained. This also applies to payment of the first premium for each insurance policy. 

 § 13 - Signage/Advertising

  

	13.1	The Lessee shall be permitted to place nameplates and company signs in the entrance area and at the doors to the rented rooms in those places designated by the Lessor
for this purpose. Other building sections or areas of the property are not part of this lease; advertising installations, vending machines, display windows, stands, signs, awnings, antennae, etc., may therefore not be installed or set up.

  

	13.2	Any additional advertising installations or materials pursuant to item 13.1 that the Lessee wishes to install or set up shall require the Lessee to obtain the Lessor's
written, prior consent, which may involve conditions and expenses to be paid by the Lessee. 

  

	13.3	The Lessor shall reserve the right to make sure that signage or any advertising or other installations are designed in accordance with a joint advertising concept for
the property. The Lessee must adjust his signage and advertising and other installations so that they correspond to this uniform concept. The Lessee shall bear the costs for signage. 

 

 Page 8 of the Lease Agreement of December 21, 2004 

 § 14 - Property Surveillance and Security Systems 

 

	14.1	Should the Parties deem surveillance measures necessary for the property, the Lessee shall tolerate these to the extent he is notified of said measures in due time. The
Lessee shall be obliged to bear any costs incurring with respect to this matter. If there are several lessees, these costs shall be divided among them in accordance with the scale used for other operating expenses and service charges.

  

	14.2	This shall also apply should the Lessor install security systems. Installation of security systems inside the premises by the Lessee shall require the prior consent
from the Lessor. 

 § 15 - Defects to Leased Object/Counterclaims 

The legal provisions shall apply. 
 § 16 - Modifications to Leased Object made by the Lessee 
  

	16.1	Modifications made to and in the leased object, particularly rebuilding, fixtures, installations and similar modifications, may only be made after obtaining written
consent from the Lessor. 

  

	16.2	Gas, electronic and other devices may only be hooked up to the available supply network to an extent that does not exceed the usage limit designated for the leased
object. 

 § 17 - Modifications to Leased Object made by the Lessor 

 

	17.1	The Lessor shall have the right to make repairs and structural changes that become necessary or are advisable for maintenance, to avoid possible hazards, repair damages
or improve the leased object and rental thereof even without the Lessee's consent. The Lessee shall make sure that the affected rooms and space are accessible and may not prevent or delay completion of the work; should he do this, the Lessee shall
pay for any damage that arises. 

  

	17.2	The Lessor shall make allowances for the Lessee's business affairs. In particular, the Lessor shall inform the Lessee of such work in due time. This obligation to
inform the Lessee shall not apply in the case of imminent danger. 

  

 Page 9 of the Lease Agreement of December 21, 2004 

 § 18 - Accessing and Entering the Leased Object 

The Lessee shall guarantee that the Lessor or his agents, experts or interested parties are able to enter and view the leased object at
any time during standard business hours for the purposes of re-letting, sale, assessing the condition of the leased object or doing work on the leased object, if the Lessee has been notified in advance. 

The Lessee shall guarantee that the leased object can be accessed and entered at any time of day or night in the case of imminent danger.

 § 19 - Lessor’s Lien / Provision of Security 

 

	19.1	The Lessor has a lessor’s lien on items brought into the leased object by the Lessee (office furniture, machines and other objects for business use and furnishing)
for all present and future claims under this Agreement. 

  

	19.2	If third parties pledges items brought into the leased object by the Lessee, the Lessee shall be obliged to immediately notify the Lessor of the details and scope of
the pledge by providing him with the relevant documents. 

  

	19.3	At least 14 days prior to the commencement of the lease pursuant to section 4.1 the Lessee shall provide security (guarantee) in the amount of [...***...]
rent plus the agreed or estimated operating expenses and service charges as well as the applicable value-added tax in the amount of 

 [...***...] 
 [...***...] 

as security for all the Lessor's claims under this Agreement and its termination. 

(Translator’s note: The amount indicated in numbers and that indicated in words do not correspond in the original document and
have therefore been translated as such.) 
 Security shall be provided in the form of an unconditional, irrevocable and
unlimited guarantee for which the Lessee is liable as the sole principal from a major bank headquartered in the Federal Republic of Germany for which the guaranteeing bank shall waive the right to appeal, to offset and to deposit and the rights and
objections from sections 768 and 776 of the German Civil Code (BGB) and which is obligated to pay on the first request to do so by the Lessor. 
 The guarantee may not contain any further conditions or limitations beyond the provision that the guarantee obligation shall be returned, if the Lessor returns the bank guarantee to the guarantor or if
the lease is terminated and all of the Lessee's obligations arising from said lease have been fulfilled, if applicable reduced by the amount claimed by the Lessor. 

 

 Page 10 of the Lease Agreement of December 21, 2004 

 

			
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	19.4	In the event changes are made to basic rent during tenancy and/or to the operating expenses and service charges by at least [...***...] of the previous monthly
total, the Lessee shall be obliged to adjust his provision of security accordingly, if requested to do so by the Lessor within 14 days of receiving said request. 

 § 20 - Termination of Lease 
  

	20.1	Once lease has been terminated, the Lessee shall return the leased object cleaned and in suitable condition together with all keys to the Lessor. The Lessee shall also
conduct any necessary decorative repairs, maintenance and other repairs that he is obligated to conduct pursuant to section 11 until the end of the lease; should the Lessee fail to do so, the Lessor may conduct such repairs and measures himself
instead of the Lessee at the Lessee's cost without reminding the Lessee that he is obligated to make such repairs. 

  

	20.2	Objects that the Lessee has placed in the leased object and any changes made by him to the leased object during the lease, particularly fixtures and renovation,
including signage, advertising installations and other installations in accordance with item 13 of this Agreement must be professionally removed and the original state of the lease object needs to be established by the Lessee.

 The Lessee shall not remove the cabling, the built-in server room and the air conditioning unit located in the
server room present in the premises at the commencement of the lease, after moving out of the leased object. 
 The Lessor may
avert the exercise of this right to remove an article by paying suitable compensation based on the current value of the object. 
  

 Page 11 of the Lease Agreement of December 21, 2004 

 

			
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 § 21 Miscellaneous 

 

	21.1	Place of fulfillment and court of jurisdiction for all obligations in connection with this Agreement shall be Mannheim, Germany. 

 

	21.2	Should one or more provisions of this Agreement be invalid, this shall not affect the validity of the other provisions. The Parties shall replace the invalid provision
by an effective provision with retroactively effect, on which they would reasonably have agreed had they previewed the invalidity or absence of the respective provision. 

 

	21.3	Supplementary agreements, changes, additions and cancellation of the Agreement are only effective if conducted in writing. This also applies to any kind of permission
or consent. The written form requirement may only be waived expressly and in written form. In particular, any declarations arising within the scope of this Agreement such as cancellations, consent, permits and similar declarations shall be made in
writing to be effective. 

  

	21.4	The built-in server room in the offices, including technical installations (e.g., additional cabling, air conditioning unit) as well as the additional door closing
system including installations shall remain in the premises after the Lessee has moved out. 

  

	21.5	Reference shall be made to the Annexes I - II associated with this Agreement. 

 

							
	Essen, January 6, 2005	 		 	Munich, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]     [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 12 of the Lease Agreement of December 21, 2004 

 Annex I to the Lease Agreement AHV / Nitec Pharma 
 LIST OF OPERATING EXPENSES AND SERVICE CHARGES 
 The following running costs that are
incurred by the owner due to his ownership of the property or due to the intended use of the building or the economic unit, the adjoining buildings, facilities, installations and property, unless they are usually borne directly by the Lessee in
addition to the rent, constitute the operating expenses and service charges: 
  

	1.	Current public rates and charges for the property 

 These namely comprises the land tax. 
  

	2.	Costs for water supply 

These comprise the costs for water consumption, basic charges and charges for renting meters, costs for using intermediate meters as well
as operating costs. 
  

	3.	Drainage costs 

 These
comprise the charges for use of a public drainage system, including discharge of rainwater as well as operating costs. 
  

	4.	Heating system costs 

These comprise the operating and cleaning costs 
  

	 	a)	for the heating system as well as the costs for using measuring equipment to measure consumption. Heating systems may, for example, be central heating systems or
heating systems connected to the hot water supply system, central fuel supply systems or floor heating systems 

  

	 	b)	costs for district heating and operating costs 

  

	 	c)	costs for reading and analysis of the equipment to measure consumption. 

  

	5.	Costs of hot water supply 

These include the operating and cleaning costs for 
  

	 	a)	hot water supply facilities, such as central hot water supply facilities or hot water supply facilities connected to the heating system; 

 

	 	b)	costs for supplying with district hot water and operating costs for the associated facilities in the building; 

 

 Page 1 of the Annex I to the Lease Agreement of December 21, 2004 

	 	c)	hot water units and equipment to measure consumption; 

  

	 	d)	costs for reading and analysis of the equipment to measure consumption. 

  

	6.	Costs for air conditioning and ventilation systems 

 These comprise the operating costs. 
  

	7.	Costs for the passenger elevator or freight elevator 

 These comprise the costs for the operational electricity, supervision costs, service costs, costs of monitoring the installation and maintenance costs, costs for regularly checking it for operational
readiness and operational safety, including adjustment by an expert and cleaning costs. 
  

	8.	Costs for street cleaning and garbage disposal 

 These comprise the fees to be paid for public street cleaning and garbage disposal as well as the costs for corresponding non-public measures. 

 

	9.	Costs for cleaning and pest control 

 Cleaning costs include, among others, costs for cleaning the property, in particular access and entrance areas, corridors, staircases, basements, attic spaces, laundry rooms, technology rooms, lift cages
and facades as well as costs for glass cleaning. 
  

	10	Costs for outside facilities 

 These comprise costs for horticultural upkeep and ground maintenance, including replanting of plants and trees and the upkeep of playgrounds, including replacing sand. These also include upkeep, cleaning,
snow removal and strewing sand or other suitable material in areas, access areas and driveways that are not used for public traffic. 
  

	11.	Lighting costs 

 These
comprise the electricity costs for outdoor lighting and the indoor lighting of general building sections, such as access and entrance areas, corridors, staircases, basements, attic areas, laundry rooms and technology rooms. 

 

 Page 2 of the Annex I to the Lease Agreement of December 21, 2004 

	12.	Costs of cleaning pipes and chimneys 

 These comprise fees for cleaning pipes and chimneys pursuant to the applicable list of fees. 
  

	13.	Insurance costs 

 These
comprise the costs for all insurance policies that have been taken out for the object, such as building insurance with all-risk coverage, glass insurance, liability insurance for the building, the oil tank and the elevator as well as insurance
against loss of rent. 
  

	14.	Costs for the janitor, porter or doorman and all other staff required for building operation 

These include, inter alia, ancillary labor costs and special remuneration. 

 

	15.	Costs for signage and advertising installations 

 These comprise costs for installing and operating signs and advertising installations. Signage comprises business name, name, location and information signs. 

 

	16.	Property management costs 

These comprise the costs for property management with technical and commercial support. 

 

	17.	Costs for a lightning protection system 

  

	18.	Costs for parking facilities 

 These comprise costs for operating, cleaning and maintenance of parking facilities. 
  

	19.	Operational electricity costs 

 These comprise operational electricity costs for the common building sections and facilities, to the extent they are not borne by the users themselves or are included in the above-mentioned items.

  

	20.	Maintenance costs 

 These
comprise the costs for all maintenance work carried out on the property that are not included in the above-mentioned items. 
  

 Page 3 of the Annex to the Lease Agreement of December 21, 2004 

	21.	Other public charges 

  

	22.	Costs 

 of operation

  

	 	a)	of the common aerial system or 

  

	 	b)	the private distribution system connected to a broadband cable network or 

  

	 	c)	of the satellite reception equipment 

  

	23.	Costs for property surveillance and security installations 

 These comprise the costs for regular and special monitoring and surveillance measures as well as the costs for manufacturing, installing and operating security installations. 

 

	24.	Costs for other equipment 

These include operating costs such as those for washing machine and dryer facilities. 

 

	25.	Costs for property service charge accounts 

 These comprise the capital cost for the property service charge accounts, including bank service charges, account-keeping fees, interest charges. 

 

	26.	Other operating costs 

These comprise the operating costs not mentioned in clause 1 to 25, namely operating costs for adjoining buildings, facilities and
installations. 
  

					
	Essen, January 6, 2005	 		 	Mannheim, December 22, 2004
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]    [Illegible Signature]

	(Lessor)	 		 	 (Lessee)

	 Alters- und Hinterbliebenen-Versorgungsstelle
 der Technischen Überwachungs-Vereine (VVaG)
 Kurfürstenstraße 56

45138 Essen
	 		 	

  

 Page 4 of Annex I to the Lease Agreement of December 21, 2004 

 

 

  

 Addendum No. 1 to the Lease Agreement of January 6, 2005/December 22, 2004

 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 3-15, D- 68167 Mannheim, Germany 
 between 

Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807 
 represented
by its managing executive board member, Dr. rer. pol. G. Wiedemann, 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim, Germany, 

represented by its general manager, Mr. Jochen Mattis 
 - hereinafter referred to as the “Lessee” - 
  

	1.	Amendment of § 1 Rental Property (Translator’s note: Item 1 of the Lease Agreement is called “Leased Object” and not “Rental
Property”.) 

 The rental space shall be extended by 57.65 sqm on the second floor. The ground plan is
attached as Annex 1 to this Addendum. 
  

	3.	Amendment of § 4 Rent, Service Charges and Value-added Tax 

 As of February 1, 2006, the rent for the second floor shall be composed of the following: 
  

									
	 Presently occupied office space
	  	171.18 sqm	  	x	  	[...***...]	  	[...***...]
	 New office space
	  	57.65 sqm	  	x	  	[...***...]	  	[...***...]
	 4 underground parking spaces
	  		  		  		  	[...***...]
	 Advance payment of service charges
	  	228.83 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
					
	 Net sub-total
	  		  		  		  	[...***...]
	 16%VAT.
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total sum gross
	  		  		  		  	[...***...]

  

 Page 1 of the Addendum of December 7, 2005 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessor shall bear the costs for the relocation of electricity and server cables as well as for the fitting of carpet in the newly rented premises.

 The Lessee shall bear the costs for moving the walls. 

 

	 	2.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

					
	Essen, January 30, 2006	 		 	Mannheim, January 13, 2006
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	68167 Mannheim
	45138 Essen	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)
	[stamp: Alters-und Hinterbliebenen-Versicherung] [stamp: Fa. Nitec Pharma GmbH]

 

 Page 2 of the Addendum of December 7, 2005 

 

 

 Annex to the Addendum 

 Addendum No. 2 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 

Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen, Germany

 UST ID: DE 11 98 24807, 

represented by its executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 

68167 Mannheim, Germany, 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” -

  

	1.	Amendment to § 1 Rental Property 

 As o February 1, 2007, the rental space on the second floor shall be expanded by 214.17 sqm. The Lessee will thus occupy the complete second floor. The overall space will amount to 443 sqm.

  

	2.	Amendment to § 4 Term of Lease and Termination 

 As of February 1, 2007, the lease for the complete second floor shall be extended by another two years until January 31, 2009 [changed Jaas] 

 

	3.	Amendment to § 5 Rent 

As of February 1, 2007 the rent fort he second floor is composed as follows: 

 

									
	Basic rent for the office space on the 2nd floor	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
	Underground parking spaces 125, 126,127,128	  		  		  		  	[...***...]
	Parking spaces No. 33+32	  		  		  		  	[...***...]
		  		  		  		  	 
	Basic rent total	  		  		  		  	[...***...]
	Advance payment of service charges	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
	Net total: rent including heating	  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Total amount
	  		  		  		  	[...***...]
		  		  		  		  	 

  

 Page 1 of the Addendum No. 2 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the installation of the electricity and server cables as well as for the demolition of the added wall. 

 

	 	2.	The Lessor shall bear the costs for the fitting of carpet in the newly rented premises. 

 

	 	3.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, January 3, 2007
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Jpseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

 Page 2 of the Addendum No. 2 AHV/Nitec 

 Addendum No. 3 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck, 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler, 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

 As of April 1, 2008, the rental space shall be expanded by 247.29 sqm on the sixth floor. 
 Thus, the floor space will amount to a total of 690.29 sqm (second and sixth floor). 
  

	2.	Amendment to § 5 Rent 

As of April 1, 2008, the rent shall be composed of the following: 

 

											
	 Basic rent office space on the 2nd floor
	  	443.00 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
	 Underground parking spaces 125,126,127,128,132,133
	  		  		  		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 
	 Basic rent total
	  		  		  		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	  	x	  	[...***...]	  	=	  	[...***...]
		  		  		  		  		  	 
	 Net total: rent including heating
	  		  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  		  	[...***...]
	 Total amount
	  		  		  		  		  	[...***...]
		  		  		  		  		  	 

  

 Page 1 of the Addendum No. 3 AHV/Nitec 

 

			
		 	***Confidential Treatment Requested

	4.	Miscellaneous 

  

	 	1.	The Lessee shall bear the costs for the paintwork and the cleaning of the carpet in the offices on the sixth floor. 

 

	 	2.	The Lessor shall replace the carpet in those offices in which the carpet is heavily worn out. 

 

	 	3.	The Lessor shall bear the costs for a dishwasher. 

  

	 	4.	The furniture on the sixth floor shall be transferred to the company Nitec Pharma free of charge. 

 

	 	5.	All other provisions of the main Lease Agreement of January 6, 2005/ December 22, 2004, shall remain in force without change. 

 

							
	Essen,	 	  
	 		 	Mannheim, April 4, 2008
			
	 Alters- und Hinterbliebenen-Versicherung der
	 		 	Fa. Nitec Pharma GmbH
	 Technischen Überwachungs-Vereine WaG
	 		 	Joseph-Meyer-Str. 13-15
	 Kronprinzenstr. 30
	 		 	
			
	 45128 Essen
	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

 Annex I: Ground plan of the sixth floor

 Annex II: Underground parking spaces and parking spaces on the first floor 
  

 Page 2 of the Addendum No. 3 AHV/Nitec 

 

 

 Annex I to the Addendum No. 3 

 7.1.5 
 Addendum No. 4 to the Lease Agreement of January 6, 2005 / December 22, 2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim

 between 
 Alters- und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 
 Kronprinzenstr. 30 
 45128 Essen 
 UST ID: DE 11 98 24807, 
 represented by the executive board, Dr. rer. pol. G. Wiedemann, and
Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 
 and 
 the company 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 

68167 Mannheim 
 represented by its managing
director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 4 Term of Lease and Termination 

 The lease of the whole rented space shall be extended until December 31, 2010. 
  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005/December 22, 2004, along with all addendums shall remain in force without change. 
  

					
	 Essen, September 24, 2008
	 		 	Mannheim, September 18, 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 	(Lessee)

  

 Page 1 of the Addendum No. 4 AHV/Nitec 

 Addendum No. 5 to the Lease Agreement of January 6, 2005 / December 22,
2004 
 Object: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, D-68167 Mannheim 
 between 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807, 
 represented by the
executive board, Dr. rer. pol. G. Wiedemann, and Mr. Ralf Heynck 
 - hereinafter referred to as the “Lessor” - 

and 
 the company 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 represented by its
managing director, Dr. Achim Schäffler 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Amendment to § 1 Rental Property 

 As of April 1, 2009, the Lessee shall in addition rent a store room on the first floor. 
  

	2.	Amendment to § 5 Rent 

Thus, as of April 1, 2009 the monthly rent payment shall amount to the following: 

 

									
	 Basic rent for the office space on the 2nd floor
	  	443.00 sqm	  	x	  	[...***...]	  	[...***...]
	 Basic rent for the office space on the 6th floor
	  	247.29 sqm	  	x	  	[...***...]	  	[...***...]
	 storage area on the 1st floor
	  	18.50 sqm	  	x	  	[...***...]	  	[...***...]
	 Underground parking spaces 125, 126,127,128,132,133
	  		  		  		  	[...***...]
	 Parking spaces No. 32+33+10+11+2
	  		  		  		  	[...***...]
		  		  		  		  	 
	 Basic rent total
	  		  		  		  	[...***...]
	 + Advance payment of service charges
	  	690.29 sqm	  	x	  	[...***...]	  	[...***...]
		  		  		  		  	 
	 Net total: rent including heating
	  		  		  		  	[...***...]
	 + 19% VAT
	  		  		  		  	[...***...]

 

 ***Confidential Treatment Requested 

 

			
	Page 1 of the Addendum No. 5 AHV/Nitec	 	

									
	 Total amount
	  		  		  		  	€8,910.55
		  		  		  		  	 

  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005 / December 22, 2004, together will all addendums, shall remain in force without change. 
  

					
	Essen, March 12, 2009	 		  	Mannheim, March 12, 2009
			
	Alters- und Hinterbliebenen-Versicherung der	 		  	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-VereineVVaG	 		  	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		  	
			
	45128 Essen	 		  	68167 Mannheim
			
	 [Illegible Signature]
	 		  	 [Illegible Signature]

	(Lessor)	 		  	(Lessee)

  
 Page 2 of the Addendum No. 5
AHV/Nitec 

  
 Addendum No. 6 to
the Lease Agreement of January 6, 2005 / December 22, 2004 
 Object: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 
 between 
 Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine-WaG- 

Kurfürstenstr. 56, 45128 Essen 
 UST ID: DE
11 98 24807 
 represented by the executive board Mr. R. Heynck and Ms. S. Schwierz 
 - hereinafter referred to as “Lessor” - 
 and 

the company 
 Horizon Pharma GmbH 

in former times Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15, 68167 Mannheim 

represented by its managing director Dr. Achim Schäffler 
 - hereinafter referred to as “Lessee” - 
 Preamble 

The trade name of the company Nitec Pharma GmbH was changed to Horizon Pharma GmbH on June 22, 2010. Therefore, all rights and obligations resulting from
the existing lease agreement are simultaneously transferred to the company Horizon Pharma GmbH. 
  

	1.	Amendment to § 4 Term of Lease and Termination 

 The lease of the whole rented space shall be extended until December 31, 2011. 
  

	2.	Miscellaneous 

 All other
provisions of the main Lease Agreement of January 6, 2005 / December 22, 2004, along with all addendums shall remain in force without change. 
  

									
					
	Essen, the	 	26.8.2010	 		 	Mannheim, the	 	19. Aug. 2010
			
	 Alters-und Hinterbliebenen-Versicherung der
 Technischen Überwachungs-Vereine VVaG
 Kronprinzenstr.30
	 		 	 Fa. Horizon Pharma GmbH
 Joseph-Meyer-Str. 13-15

			
	45128 Essen	 		 	68167 Mannheim
			
	[signature]            [signature]	 		 	[signature]
	(Lessor)	 		 	(Lessee)
	[company’s stamp]	 		 	

 Page 1 of the Addendum No. 6 AHV/Horizon 

  
 7.1.4 

Parking Space 
 Lease Agreement 
 Joseph-Meyer-Str. 13-15, 68167 Mannheim 

between 
 Alters- und Hinterbliebenen
Versicherung der 
 Technischen Überwachungsvereine VVaG 
 Kurfürstenstr. 56 
 45138 Essen 
 UST ID: DE 11 98 24807 
 represented by its managing executive board member, Dr. rer. pol. G.
Wiedemann, 
 and 
 the company

 Nitec Pharma GmbH 
 Joseph-Meyer-Str.
13-15 
 68167 Mannheim 
 represented
by its managing director, Mr Jochen Mattis, 
 - hereinafter referred to as the “Lessee” - 

 

	1.	Leased Object 

 As of
August 1, 2007, the Tenant shall rent the following parking spaces in Joseph-Meyer-Str. 13-15, 68167 Mannheim: 
  

							
	 Parking spaces No. 10 +11
	  	x	  	[...***...]	  	[...***...]
	 + 16% VAT
	  		  		  	[...***...]
	 Overall rent for parking spaces per month
	  		  		  	[...***...]

  

	2.	Termination 

 The Lease
Agreement may be terminated by either party by giving one month’s notice. 
  

					
	Filderstadt, August 7, 2007	 		 	Mannheim, July 11, 2007
			
	[stamp: TÜV SÜD Immobilien Service GmbH]	 		 	[stamp: Nitec Pharma GmbH]
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Lessor)	 		 	(Lessee)

  

			
		 	***Confidential Treatment Requested

  
 ***Text Omitted and
Filed Separately 
 with the Securities and Exchange Commission. 

Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406. 

7.1.3 

MIETVERTRAG 

über Gewerberäume 
 Zwischen 
 Alters- und Hinterbliebenen-Versorgungsstelle der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstraße 58 
 45138 Essen

 -Vermieter 
 UST ID: DE 11 98 24807

 und 
 Firma 

Nitec Pharma GmbH 
 -Mieter- 

UST ID: 37009/52183 
 wird nachfolgender
Vertrag geschlossen: 

  
 MIETVERTRAG
FÜR BÜRO- UND VERWALTUNGSFLÄCHEN 
 INHALT
und ANLAGEN 
  

					
	 Seite
	  	 Inhalt

	1	  	Inhaltsverzeichnis
			
	3	  	§ 1	  	 Mietsache

	3	  	§ 2	  	 Benutzung der Mietsache

			
	4	  	§ 3	  	 Ausstattung der Mieträume

	4	  	§ 4	  	 Mietzeit, Kündigung

			
	5	  	§ 5	  	 Mietzins

			
	6	  	§ 6	  	 Umsatzsteuer

	6	  	§ 7	  	 Änderung des Mietzinses

			
	7	  	§ 8	  	 Zahlung des Mietzinses

	7	  	§ 9	  	 Übergabe und Zustand der Mietsache

	7	  	§ 10	  	 Gebrauchsüberlassung an Dritte

			
	8	  	§ 11	  	 Instandhaltung und Instandsetzung

	8	  	§ 12	  	 Versicherungen

			
	9	  	§ 13	  	 Beschilderung / Reklameanlagen

	9	  	§ 14	  	 Objektbewachung und Sicherheitseinrichtungen

			
	10	  	§ 15	  	 Mängel der Mietsache / Gegenansprüche

	10	  	§ 16	  	 Veränderungen der Mietsache durch den Mieter

	10	  	§ 17	  	 Veränderungen der Mietsache durch den Vermieter

			
	11	  	§ 18	  	 Betreten der Mietsache

	11	  	§ 19	  	 Vermieterpfandrecht/Sicherheitsleistung

			
	12	  	§ 20	  	 Beendigung des Mietverhältnisses

			
	13	  	§ 21	  	 Sonstige Vereinbarungen

			
	Anlage I	  		  	 Aufstellung der Betriebs- und Nebenkosten

	Anlage II	  		  	 Grundrisszeichnungen der Mietflächen

  
 § 1 - Mietsache

  

	1.1	Der Vermieter ist Eigentümer der Liegenschaft Joseph-Meyer-Straße 13-15, 68167 Mannheim. 

 

	1.2	 Der Vermieter vermietet an den Mieter Büroflächen in dem vorstehend beschriebenen Gebäude im 1. Obergeschoss mit insgesamt 171,18
m2, darin enthalten sind Haupt-und Nebennutzflächen
und die damit verbundenen Verkehrs- und Funktionsflächen. 

 Der beigefügte Lageplan ist Bestandteil
des Mietvertrages (Anlage II). 
  

	1.3	Solltgen sich bei nachträglicher Vermessung der Mietflächen eine Abweichung von der angegebenen Mietfläche ergeben, ist keine der Parteien berechtigt,
von diesem Vertrag zurückzutreten, ihn zu kündigen oder eine Änderung des Mietzinses zu verlangen. Die angegebenen Flächen sind zugrunde zu legen, soweit es nach den Bestimmungen dieses Vertrages auf die Größe der
vermieteten Flächen ankommt. 

  

	1.4	Die Vermietung erfolgt zur Nutzung als Bürobetrieb. 

 Eine Änderung dieses Nutzungszweckes ist nur mit schriftlicher Genehmigung des Vermieters zulässig. Etwaige Genehmigungserklärungen des Vermieters werden stets, auch wenn dies nicht
nochmals ausdrücklich gesagt ist, vorbehaltlich einer etwa erforderlichen behördlichen Genehmigung zur Nutzungsänderung erteilt, deren Beschaffung dem Mieter auf eigene Kosten obliegt und die dem Vermieter nachzuweisen ist.

 § 2 - Benutzung der Mietsache 
  

	2.1	Die Mietsache wird zu dem in Ziff. 1.4 genannten Nutzungszweck durch den Mieter gemietet. 

 

	2.2	Der Vermieter übernimmt keine Gewähr dafür, dass der vorgesehene Betrieb des Mieters in der Mietsache öffentlich-rechtlich zulässig ist. Der
Mieter hat auf seine Kosten sämtliche Voraussetzungen für seinen Betrieb zu schaffen und während der Mietzeit aufrechtzuerhalten. Auflagen der Gewerbeaufsicht oder anderer Stellen hat der Mieter auf eigene Kosten zu erfüllen,
auch soweit es sich urn Raumbezogene Auflagen handelt. 

 Die GüItigkeit dieses Mietvertrages ist
unabhängig von einer etwa erforderlichen behördlichen Zulassung der gewerblichen Tätigkeit des Mieters. 
  

	2.3	Der Mieter verpflichtet sich, für die Dauer dieses Vertrages seinen vorgesehenen Betrieb in den Mieträumen aktiv zu betreiben und entsprechend seiner
Betriebsart geöffnet bzw. besetzt zu halten (Betriebspflicht). 

  

	2.4	Der Vermieter räumt dem Mieter keinerlei Konkurrenzschutz ein. 

  
 Seite 34 des Mietvertrages
vom 21.12.2004 

  

	2.5	Vor der Aufstellung von Maschinen, schweren Gegenständen, anderen Anlagen und Einrichtungen in den Mieträumen hat sich der Mieter über die zulässige
Bela-stungsgrenze der Stockwerksdecken beim Vermieter zu erkundigen und seine schriftliche Zustimmung einzuholen. Für Schäden, die durch Nichtbeachtung dieser Bestimmungen eintreten, haftet der Mieter. Führen solche Anlagen und
Einrichtungen des Mieters zu nachteiligen Auswirkungen auf das Gebäude (Erschütterungen, Risse usw.) oder zu Nachteilen oder Unzuträglichkeiten (z. B. Lärm, Staub, störende Gerüche etc.) der Mitbenutzer im Gebäude,
so kann der Vermieter die Zustimmung widerrufen und vom Mieter Unterlassung verlangen. 

  

	2.6	Zur Anmietung gehört auch das Recht des freien Zugangs und der freien Zufahrt zur Mietsache. 

§ 3 - Ausstattung und Übergabe der Mieträume durch den Vermieter 

 

	3.1	Der Zustand und die Ausstattung der Mietsache, wie sie steht und liegt, ist dem Mieter bekannt. 

 

	3.2	Die Mietsache wird dem Mieter spätestens Januar 2005 übergeben. Von der Übergabe ist ein Protokoll zu erstelien. 

§ 4 - Mietzeit und Kündigung 
  

	4.1	Das Mietverhältnis beginnt am 01. Januar 2005 und wird auf die Dauer von 1,5 Jahren bis zum 30.06.2006 abgeschlossen. Bei Beendigung des Mietverhältnisses
findet § 568 BGB für die Vertragsparteien keine Anwendung. 

  

	4.2	Während der Dauer des Mietverhältnisses ist die ordentliche Kündigung ausge-schlossen. Das Recht zur außerordentlichen fristlosen Kündigung
aus wichtigem Grund beider Parteien bleibt unberührt. Ein wichtiger außerordentlicher Kündigungsgrund für den Vermieter liegt insbesondere vor, wenn 

 

	 	a)	der Mieter mit mehr als einer Monatsmiete in Rückstand gerät oder die vereinbarte Sicherheitsleistung nicht in der nach diesem Vertrag vorgesehenen Zeit,
Höhe und Art gestellt hat; 

  

	 	b)	der Mieter ohne Zustimmung des Vermieters die Mietsache oder Teile davon baulich verändert oder zu anderen als im Vertrag bestimmten Zwecken benutzt, insbesondere
Dritten zum Gebrauch überlässt bzw, untervermietet; 

  

	 	c)	der Mieter seine Zahlungen einstellt, es zur Einleitung eines gerichtlichen oder außergerichtlichen Vergleichs—oder Konkursverfahrens über sein
Vermögen—kommen lässt oder die eidesstattliche Versicherung über sein Vermögen ableisten muß; 

  
 Seite 35 des Mietvertrages
vom 21.12.2004 

  

	 	d)	der Mieter in derselben Sache trotz zweimaliger schriftlicher Abmahnung die Vertragsbedingungen nicht einhält. 

 

	4.3	Dem Mieter wird die Option eingeräumt, das Vertragsverhältnis nach Ablauf der unter Punkt 4.1 geregelten Mietvertragslaufzeit um ein, zwei oder drei Jahre zu
verlängem. Nimmt der Mieter von seinem Optionsrecht Gebrauch, so hat er dies in schriftlicher Form dem Vermieter 6 Monate vor jeweiligem Ablauf des Mietverhältnisses mitzuteilen. Die Kündigung hat 6 Monate vor dem jeweiligen Ablauf zu
erfolgen. 

  

	4.5	Soweit der Mieter eine natürliche Person ist, wird das vorzeitige Kündigungsrecht gemäß § 569 BGB hiermit ausgeschlossen.

 § 5 Mietzins 
  

	5.1	Der Mietzins setzt sich für die Grundmietzeit vom 01.01.05 – 30.06.05 monatlich wie folgt zusammen: 

 

									
	 Bürofläche
	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
	 3 Tiefgaragensteliplätze
	  		  		  		  	[...***...]
	 Nebenkostenvorauszahlung
	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
					
	 Zwischensumme netto
	  		  		  		  	[...***...]
	 Mehrwertsteuer 16 %
	  		  		  		  	[...***...]
					
	 Summe brutto gesamt
	  		  		  		  	[...***...]

 Sollte der Mieter die in § 4 vereinbarte Option über 1 Jahr ausüben, bleibt der Mietzins in Höhe von [...***...] bestehen, bei 2 jähriger Dauer reduziert sich der Mietzins
pro m2 auf [...***...,] bei 3 jähriger Dauer
auf [...***...] pro m2. 

 

	5.2	Zusätzlich zur Grundmiete übernimmt der Mieter alle für die Mietsache bei ihm direkt anfallenden Betriebskosten (z. B. Strom, Gas, Wasser, Telefon- und
andere Kommunikationskosten) sowie sämtliche Betriebs- und Nebenkosten des Hauses. Betriebs- und Nebenkosten sind alle in der Anlage I zu diesem Vertrag aufgeführten Kosten sowie alle etwaigen künftig entstehenden Kosten, die
durch Gesetz, Verordnung, Ortssatzung oder auf sonstiger Grundlage künftig neu für das Mietobjekt eingeführt werden. Bei der Aufstellung der Betriebs- und Nebenkosten gemäß Anlage I handelt es sich daher um eine
beispielhafte und nicht um eine abschließende Aufzählung möglicher anfallender Kosten. 

  

	5.3	Diese Betriebs- und Nebenkosten werden vom Vermieter auf den Mieter umgelegt und mit ihm abgerechnet. Bei mehreren Mietem im Gebäude bestimmt der Vermieter den
Umlagemaßstab (Verteilungsschlüssel) nach seinem Ermessen, soweit zwingende gesetzliche Bestimmungen dies vorschreiben, gemäß diesen Bestimmungen. Grundsätzlich richtet sich der Verteilungsschlüssel nach dem Anteil
der vermietbaren Fläche an der Gesamtfläche. 

  
  

***Confidential Treatment Requested 
 Seite 5 des Mietvertrages vom 21.12.2004 

  

	5.4	Die Abrechnung erfolgt jährlich durch den Vermieter spätestens bis zum 15.12. des Folgejahres. Endet das Mietverhäitnis während einer
Abrechnungsperiode, wird die Abrechnung im Rahmen der nächstfolgenden Jahresabrechnung vorgenommen. 

  

	5.5	Erhöhen sich die Betriebskosten oder sind Erhöhungen sicher zu erwarten (z. B. durch Ankündigung kommunaler Gebührenerhöhungen), so ist der
Vermieter berechtigt, eine entsprechende Erhöhung der Vorauszahlungen zu verlangen. 

 § 6 Umsatzsteuer

  

	6.1	Zuzüglich zur vereinbarten Grundmiete einschließlich der Betriebs- und Nebenkosten hat der Vermieter die Umsatzsteuer in ihrer jeweiligen gesetzlichen
Höhe zu entrichten. Der Mieter versichert, dass er die Mieträume ausschließlich für Umsätze verwendet oder zu verwenden beabsichtigt, welche den Vorsteuerabzug beim Vermieter nicht ausschließen. Sollte der Mieter
entgegen dieser Zusicherung die Mieträume nicht ausschließlich für solche Umsätze verwenden, die den Vorsteuerabzug nicht ausschließen (steuerschädliche Verwendung), so erhöht sich die Grundmiete
einschließlich Nebenkosten im Zeitraum der umsatzsteuerschädlichen Verwendung um denjenigen Betrag, welcher der jeweiligen auf die Grundmiete zuzüglich Betriebs- und Nebenkosten zu entrichtenden Umsatzsteuer entspricht.

  

	6.2	Auf Verlangen des Vermieters ist der Mieter verpflichtet, die ausschließliche Verwendung der Mietsache für Umsätze, die den Vorsteuerabzug nicht
ausschließen, nachzuweisen. Der Mieter hat den bevorstehenden Beginn einer solchen steuerschädlichen Verwendung dem Vermieter unverzüglich anzuzeigen und ihm jeglichen Schaden zu ersetzen, der diesem aus einer Verletzung der
Anzeigepflicht erwächst; hierzu zählt insbesondere jeder Schaden beim Vermieter daraus, dass dieser nach Beginn der steuerschädlichen Verwendung Umsatzsteuern an das Finanzamt abführt, obwohl nunmehr eine umsatzsteuerfreie
Vermietung vorliegt. Schadensersatzansprüche dieser Art verjähren nicht vor Ablauf von 6 Monaten nach bestandskräftiger Feststellung durch eine Finanzbehörde oder ein Finanzgericht, dass der Vermieter nicht oder nicht mehr zum
Vorsteuerabzug berechtigt ist. 

 § 7 - Änderung des Mietzinses 

 

	7.1	 Ändert sich der vom Statistischen Bundesamt festgesteilte Preisindex für die Lebenshaltung aller privaten Haushalte (Verbraucherpreisindex
für Deutschland) (Basisjahr 2000 = 100 Punkte) gegenüber dem Stand 30.06.2009 oder gegenüber der letzten Mietanpassung um mehr als [...***...], so ändert sich jeweils die in § 5 vereinbarte Grundmiete prozentual entsprechend. Die
Änderung wird von dem Monatsersten an wirksam, der auf die Veränderung folgt. 

  
  

***Confidential Treatment Requested 
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	7.2.	Sollte diese Wertsicherungsklausel nicht gem. § 4 der Preisklauselverordnung als genehmigt gelten, so verpflichten sich die Parteien eine dem wirtschaftlichen Sinn
und Zweck am ehesten entsprechende Wertsicherungsklausel zu vereinbaren, die nach den dann geltenden Vorschriften genehmigungsfähig ist. 

 § 8 - Zahlung des Mietzinses 
 Die Mietzinszahlung beginnt am
01.01.2005. 
 Der Mietzins ist spätestens bis zum 3. Werktag eines jeden Monats auf das Konto der [...***...]

 § 9 - Übergabe der Mietsache / Zustand der Mietsache 

 

	9.1	Die Übergabe der Mietsache ist vorgesehen für den Zeitpunkt des Mietbeginns gemäß § 4.1. Den verbindlichen Übergabetermin teilt der
Vermieter dem Mieter schriftlich so früh wie möglich mit. 

 Ausstehende Restarbeiten, wie z. B. die
völlige Herstellung der Außenanlagen und/oder die Mängelbeseitigung, hindem die Übernahme der Mietsache nicht. 
  

	9.2	Anlässlich der Übergabe wird von den Parteien ein Übergabeprotokoll gefertigt, das den Zustand der Mietsache und etwaige Mängel zu diesem Zeitpunkt
dokumentiert. 

 Übergabeprotokoll festgestellte Mängel hat der Vermieter innerhalb einer angemessenen
Nachfrist zu beseitigen. 
 § 10 - Gebrauchsüberlassung an Dritte 

 

	10.1	Jede ganze oder teilweise Gebrauchsüberlassung an Dritte, insbesondere die Untervermietung der Mietsache, bedarf vor Abschluss der Zustimmung des Vermieters. Ein
Kündigungsrecht des Mieters wegen Verweigerung dieser Zustimmung ist ausgeschlossen. Sind für eine anderweitige Nutzung, welche der Vermieter genehmigt hat, im Rahmen einer solchen Gebrauchsüberlassung Behördenauflagen zu
erfüllen, gehen auch diese ausschließlich zu Lasten des Mieters. 

  

	10.2	Der Vermieter kann die Zustimmung zur Untervermietung aus wichtigem Grund widerrufen. Dies darf jedoch nicht zur Unzeit geschehen. 

  
  

***Confidential Treatment Requested 
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 § 11 –
Instandhaltung/Instandsetzung/Schönheitsreparaturen/Haftung für Schäden 
  

	11.1	Dem Mieter obliegen die Schönheitsreparaturen sowie die sonstigen Instandhaltungs- und Instandsetzungsarbeiten innerhalb der Mieträume, soweit die
Schäden durch den Gebrauch des Mieters entstanden sind (Abnutzung, Verschleiß, Beschädigung durch den Mieter oder seine ErfüIlungsgehilfen). 

 § 12 - Versicherungen 
  

	12.1	Die übliche Gebäudeversicherung (Feuer, Sturm, Leitungswasser, Extended Coverage) und die Gebäudehaftpflichtversicherung werden vom Vermieter zu Lasten
der Betriebs- und Nebenkosten abgeschlossen. Durch den Mieter vorgenommene Ein-, Aus- oder Umbauten des Mietobjektes sind nicht von der Gebäudeversicherung gedeckt. Der Mieter ist verpflichtet, diese Ein-, Aus- oder Umbauten auf eigene Kosten
selbst zu versichem. 

  

	12.2	Der Mieter ist verpflichtet, eine ausreichende Betriebshaftpflicht- sowie eine Einbruchdiebstahlversicherung und eine ausreichende Versicherung der eingebrachten
Einrichtungen und Sachen gegen alle Beschädigungen auf eigene Kosten abzuschließen und für die Dauer der Mietzeit aufrechtzuerhalten. 

  

	12.3	Der Vermieter hat das Recht, sich von dem ordnungsgemäßen Abschluss der gem. § 12.2 vom Mieter abzuschließenden Versicherungen und deren
Aufrechterhaltung durch Einsichtnahme in die Versicherungsverträge zu überzeugen. Dies gilt ebenso über die Zahlung der Erstprämie der jeweiligen Versicherung. 

§ 13 - Beschilderung Reklameanlagen 
  

	13.1	Dem Mieter ist das Anbringen von Namens- und Firmenschildem im Eingangsbereich und im Bereich der Eingangstüren zu ihren Mieträumen an den vom Vermieter
hierfür vorgesehenen Stellen gestattet. Sonstige Gebäudeteile oder Flächen des Anwesens sind nicht mitvermietet; Reklameanlagen, Warenautomaten, Schaukästen, Verkaufsstände, Schilder, Markisen, Antennen u. ä.
dürfen daher dort nicht angebracht oder aufgestellt werden. 

  

	13.2	Darüber hinausgehende Reklameanlagen oder andere Einrichtungen gemäß § 13.1, welche der Mieter anbringen oder aufstellen will, bedürfen der
vorherigen, schriftlichen Genehmigung des Vermieters, die auch mit Auflagen und Kostentragungspflichten verbunden werden kann. 

  

	13.3	Der Vermieter behält sich vor, die Beschilderung oder das Anbringen von Reklameanlagen und sonstigen Vorrichtungen einheitlich nach einem gemeinschaftlichen
Werbekonzept für das Anwesen zu gestalten. Diesem einheitlichen Konzept hat sich der Mieter mit seiner Beschilderung und seinen Reklameanlagen und sonstigen Vorrichtungen anzupassen. Die Kosten der Beschilderung trägt der Mieter.

  
 Seite 39 des Mietvertrages
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 § 14 - Objektbewachung und
Sicherheitseinrichtungen 
  

	14.1	Falls die Parteien für das Objekt Bewachungsmaßnahmen als notwendig betrachten, sind diese vom Mieter zu dulden, soweit sie ihm rechtzeitig angezeigt werden.
Der Mieter verpflichtet sich, die hierfür anfallenden Kosten zu tragen, bei mehreren Mietem anteilig nach dem Umlagemaßstab für andere Betriebs- und Nebenkosten. 

 

	14.2	Dies gilt entsprechend für den Fall der Installation von Sicherheitseinrichtungen durch den Vermieter. Die Installation von Sicherheitseinrichtungen innerhalb der
Mieträume durch den Mieter bedarf der vorherigen Zustimmung des Vermieters. 

 §15 Mängel der
Mietsache/Gegenansprüche 
 Es gelten die gesetzlichen Regelungen 

§ 16 - Veränderungen der Mietsache durch den Mieter 
  

	16.1	Veränderungen an und in der Mietsache, insbesondere Um- und Einbauten, Installationen und dergleichen dürfen nur mit schriftlicher Einwilligung des Vermieters
vorgenommen werden. 

  

	16.2	Gas-, Elektro- und sonstige Geräte dürfen nur in dem Umfang an das vorhandene Leitungsnetz angeschlossen werden, als die für die Mietsache vorgesehene
Belastung nicht überschritten wird. 

 § 17 - Veränderungen der Mietsache durch den Vermieter 

 

	17.1	Der Vermieter darf Ausbesserungen und bauliche Veränderungen, die zur Erhaltung oder zur Abwendung drohender Gefahren oder zur Beseitigung von Schäden oder
zur Verbesserung der Mietsache und ihrer Vermietung notwendig oder zweckmäßig werden, auch ohne Zustimmung des Mieters vornehmen. Der Mieter hat die in Betracht kommenden Räume zugänglich zu halten und darf die Ausführungen
der Arbeiten nicht hindern oder verzögem; andernfalls hat er den dadurch entstehenden Schaden zu ersetzen. 

  

	17.2	Auf die betrieblichen Belange des Mieters ist angemessene Rücksicht zu nehmen. Insbesondere hat der Vermieter die Durchführung solcher Arbeiten rechtzeitig
anzukündigen. Die Ankündigungspflicht gilt nicht bei Gefahr im Verzug. 

  
 Seite 9 des Mietvertrages vom
21.12.2004 

  
 § 18 - Betreten der Mietsache

 Der Mieter hat während der üblichen Geschäftszelt zu gewährleisten, dass der Vermieter oder seine
Beauftragten, Sachverständige und Interessenten die Mietsache zum Zwecke der Neuvermietung, des Verkaufes, zur Feststellung des Zustandes oder zur Vornahme von Arbeiten jederzeit - nach Voranmeldung - betreten und besichtigen können.

 In Fällen von Gefahr im Verzug ist das Betreten der Mietsache zu jeder Tages- und Nachtzeit durch den Mieter zu
ermöglichen. 
 § 19 - Pfandrecht des Vermieters / Sicherheitsleistung 

 

	19.1	Der Vermieter hat für alle auch künftigen Forderungen aus diesem Vertrag ein Pfandrecht an den eingebrachten Sachen des Mieters (Büromöbel,
Maschinen und sonstige Gegenstände der Geschäftsausstattung und Einrichtung). 

  

	19.2	Bei Pfändung eingebrachter Sachen durch Dritte verpflichtet sich der Mieter, den Vermieter unverzüglich unter Vorlage der Unterlagen von den Einzelheiten und
dem Umfang der Pfändung zu benachrichtigen. 

  

	19.3	Der Mieter leistet zur Absicherung aller Ansprüche des Vermieters aus diesem Mietvertrag und seiner Beendigung spätestens 14 Tage vor Mietbeginn
gemäß § 4.1 eine Sicherheitsleistung (Bürgschaft) in Höhe von [...***...] zuzüglich vereinbarter oder geschätzter Betriebs- und Nebenkosten und zuzüglich der jeweiligen gesetzlichen
Mehrwertsteuer, in Höhe von 

 [...***...] 

[...***...] 
 Diese Sicherheitsleistung ist in Form einer unbedingten, unwiderruflichen, unbefristeten und selbstschuldnerlschen Bürgschaft einer in der Bundesrepublik Deutschland ansässigen Großbank zu
erbringen, bei welcher die bürgende Bank auf das Recht zur Anfechtung, zur Aufrechnung, zur Hinterlegung und die Rechte und Einreden aus §§ 768, 776 BGB verzichtet und sich zur Zahlung auf erstes Anfordern durch den Vermieter
verpflichtet hat. 
 Die Bürgschaft darf über die Bestimmung hinaus, dass die Bürgschaftsverpflichtung mit
Rückgabe der Bürgschaftsurkunde durch den Vermieter an die Bürgen oder dann, wenn nach Beendigung des Mietverhältnisses sämtliche Verpflichtungen des Mieters aus dem Mietverhältnis erfüllt sind, zurückzugeben
ist, gegebenenfalls um vom Vermieter in Anspruch genommene Beträge gemindert, keine weiteren Bedingungen und Einschränkungen enthalten. 

  
  

***Confidential Treatment Requested 
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	19.4	Kommt es während der Mietzeit zu einer Veränderung der Grundmiete und/oder der Betriebs- und Nebenkosten um mindestens [...***...] des bisherigen
monatlichen Gesamtbetrages, so ist der Mieter auf Verlangen des Vermieters zu einer entsprechenden Anpassung seiner Sicherheitsleistung binnen 14 Tagen ab Aufforderung verpflichtet. 

§ 20 - Beendigung des Mietverhältnisses 
  

	20.1	Bei Beendigung des Mietverhältnisses hat der Mieter die Mietsache gereinigt in ordnungsgemäßem Zustand mit sämtlichen Schlüsseln an den
Vermieter herauszugeben. Spätestens bis zum Zeitpunkt des Mietendes hat der Mieter ferner in jedem Fall notwendige, die ihm nach § 11 obliegenden Schönheitsreparaturen, Instandhaltungs- und Instandsetzungsmaßnahmen
vollständig durchzuführen; andernfalls kann der Vermieter auf Kosten des Mieters ohne nochmalige Mahnung und Fristsetzung solche Reparaturen und Maßnahmen anstelle des Mieters auf dessen Kosten selbst durchführen.

  

	20.2	Einrichtungen, mit welchen der Mieter die Mietsache versehen hat und alle von ihm etwa während der Mietzeit vorgenommenen Änderungen der Mietsache,
insbesondere Ein- und Umbauten, einschließlich Beschilderungen, Reklameanlagen und sonstiger Vorrichtungen gemäß § 13 dieses Vertrages, hat der Mieter auf seine Kosten vor Auszug fachgerecht zu entfemen und den
ursprünglichen Zustand der Mietsache wieder herzustellen. 

 Die bei Mietbeginn in den Mieträumen
befindlichen Verkabelungen, der eingebaute Serverraum und die im Serverraum befindliche Klimaanlage ist nach dem Auszug des Mieters nicht zurückzubauen. 
 Der Vermieter kann die Ausübung dieses Wegnahmerechts durch Zahlung einer angemessenen Entschädigung abwenden, die sich nach dem Zeitwert der Einrichtung bestimmt. 

  
 Seite 11 des Mietvertrages
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 § 21 - Sonstige Vereinbarungen

  

	21.1	Erfüllungsort und Gerichtsstand für alle sich aus diesem Vertrag ergebenden Verpflichtungen ist Mannheim. 

 

	21.2	Durch die Ungültigkeit einer oder mehrerer Bestimmungen dieses Vertrages wird die Gültigkeit der übrigen nicht betührt Für den Fall der
Nichtigkeit einzelner Bestimmungen sind die Parteien verpflichtet, an ihrer SteIle eine solche Regelung zu treffen, die der ursprünglichen vorgestellten mit rückwirkender Kraft am nächsten kommt. 

 

	21.3	Nebenabreden, Änderungen, Ergänzungen und Aufhebung des Vertrages sind nur wirksam, wenn sie schriftlich vereinbart werden. Das gleiche gilt für Zusagen
und Zustimmungen aller Art. Auf die Schriftform kann nur schriftlich und ausdrücklich verzichtet werden. Insbesondere bedürfen der Schriftform alle im Rahmen dieses Vertrages anfallenden Erklärungen, wie Kündigungen,
Zustimmungen, Genehmigungen und dergleichen. 

  

	21.4	Der in den Büroräumen eingebaute Serverraum, inklusive der technischen Einrichtungen (z.B. zusätzliche Verkabelung, Klimaanlage) sowie die
zusätzliche Türschließanlage incl. der Installationen verbleibt beim Auszug des Mieters in den Räumlichkeiten. 

  

	21.5	Auf die zu diesem Vertrag gehörenden AnIagen I - II wird Bezug genommen. 

 

					
	Essen, den 06.01.2005	 		 	Munich, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  
 Seite 12 des Mietvertrages
vom 21.12.2004 

  
 Anlage I zum Mietvertrag AHV / Fa.
Nitec Pharma 
 AUFSTELLUNG DER BETRIEBS- UND NEBENKOSTEN 
 Betriebskosten und Nebenkosten sind nachstehende Kosten, die dem Eigentümer durch das Eigentum am Grundstück oder durch den Bestimmungsmäßigen Gebrauch des Gebäudes oder der
Wirtschaftseinheit, der Nebengebäude, Anlagen, Einrichtungen und des Grundstückes laufend entstehen, es sei denn, dass sie üblicherweise vom Mieter außerhalb der Miete unmittelbar getragen werden: 

 

	1.	Die laufenden öffentlichen Lasten des Grundstücks 

 Hierzu gehört namentlich die Grundsteuer. 
  

	2.	Die Kosten der Wasserversorgung 

 Hierzu gehören die Kosten des Wasserverbrauchs, die Grundgebühren und die Zählermiete, die Kosten der Verwendung von Zwischenzählern und die Kosten des Betriebs. 

 

	3.	Die Kosten der Entwässerung 

 Hierzu gehören die Gebühren für die Benutzung einer öffentlichen Entwässerungs-anlage, inklusiv der Einleitung von Regenwasser und die Kosten des Betriebs. 

 

	4.	Die Kosten der Heizungsanlage 

 Hierzu gehören die Kosten des Betriebs und der Reinigung 
  

	 	a)	der Heizungsanlage sowie die Kosten der Verwendung einer messtechnischen Ausstattung zur Verbrauchserfassung. Heizungsanlagen können z.B. zentrale Heizungsanlage
oder mit der Warmwasserversorgungsanlage verbundene Heizungsanlagen, zentrale Brennstoffversorgungsanlagen oder Etagenheizungen sein; 

  

	 	b)	die Kosten der Versorgung mit Fernwärme und die Kosten des Betriebes 

  

	 	c)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

  
 Seite 13 des Mietvertrages
vom 21.12.2004 

  

	5.	Die Kosten der Warmwasserversorgung 

 Hierzu gehören die Kosten des Betriebs und der Reinigung 
  

	 	a)	der Warmwasserversorgungsanlagen, wie z. B. zentrale oder mit der Heizungs-anlage verbundene Warmwasserversorgungsanlagen; 

 

	 	b)	die Kosten der Versorgung mit Femwarmwasser und die Kosten des Betriebs der zugehörigen Hausanlagen; 

 

	 	c)	der Warmwassergeräte und Geräte zur Verbrauchserfassung; 

  

	 	d)	die Kosten der Ablesung und Auswertung der Geräte zur Verbrauchserfassung. 

 

	6.	Die Kosten der Klima-, Be- und Entlüftungsanlagen 

 Hierzu gehören die Kosten des Betriebs 
  

	7.	Die Kosten des maschinellen Personen- oder Lastenaufzuges 

 Hierzu gehören die Kosten des Betriebsstroms, die Kosten der Beaufsichtigung, der Bedienung, Überwachung und Pflege der Anlage, der regelmäßigen Prüfung ihrer
Betriebsbereitschaft und Betriebssicherheit einschl. der Einstellung durch einen Fachmann und die Kosten der Reinigung. 
  

	8.	Die Kosten der Straßenreinigung und MüIlabfuhr 

 Hierzu gehören die für die öffentliche Straßenreinigung und Müllabfuhr zu entrichtenden Gebühren und die Kosten entsprechender nicht öffentlicher Maßnahmen.

  

	9.	Die Kosten der Reinigung und Ungezieferbekämpfung 

 Zu den Kosten der Reinigung gehören u. a. die Kosten für die Säuberung des Objektes, u. a. der Zugänge, Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume,
Waschküchen, Technikräumen, Aufzugsfahrkörbe sowie Fassaden bzw. die Glasreinigung. 
  

	10.	Die Kosten der Außenanlagen 

 Hierzu gehören die Kosten der Pflege gartnerisch angelegtër Flächen einschl. der Erneuerung von. Pflanzen und Gehölzen, der Pflege von Spielplätzen einschl. der Erneuerung von
Sand. Des Weiteren die Pflege, Reinigung, Räumung und Streuung von Plätzen, Zugängen und Zufahrten, die dem nicht öffentlichen Verkehr dienen. 

  
 Seite 14 des Mietvertrages
vom 21.12.2004 

  

	11.	Die Kosten der Beleuchtung 

Hierzu gehören die Kosten des Stroms für die Außenbeleuchtung und die Beleuchtung der allgemeinen Gebäudetelle des
Objektes, wie z.B. Zugänge, Eingangsbereiche, Flure, Treppenhäuser, Keller, Bodenräume, Waschküchen und Technikräume. 
  

	12.	Die Kosten der Schornsteinreinigung 

 Hierzu gehören die Kehrgebühren nach der maßgebenden Gebührenordnung. 
  

	13.	Die Kosten der Versicherungen 

 Hierzu gehören die Kosten aller Versicherungen, die für das Objekt abgeschlossen werden, wie Gebäudeversicherung mit “all-risk”-Deckung, Glasversicherung, Haft-pflichtversicherung
für das Gebäude, den Oltank, den Aufzug, sowie Mietverlustver-sicherung. 
  

	14.	Die Kosten für den Hauswart, des Portiers bzw. Pförtners und des sonstigen für den Betrieb des Gebäubes benötigten Personals

 Hierzu gehören u.a. die Personalnebenkosten sowie Sondervergütungen. 

 

	15.	Die Kosten für Beschilderung und Werbeanlagen 

 Hierzu gehören die Kosten für die Anbringung und den Betrieb von Beschilderungs- und Reklameanlagen. Zu Beschilderungsanlagen gehören z. B. Firmen-, Namens-, Lage- und
Informationsbeschilderungen. 
  

	16.	Die Kosten des Objektmanagements 

 Hierzu gehören die Kosten des Objektmanagements mit technischer und kaufmännischer Betreuung. 
  

	17.	Die Kosten der Blilzschutzanlage 

  

	18.	Die Kosten der Garagen 

Hierzu gehören die Kosten des Betriebs und die Reinigung und Wartung der Garagenanlagen. 

 

	19.	Die Kosten des Betriebsstroms 

 Hierzu gehören die Kosten des Betriebsstroms für die gemeinschaftlichen Gebäudeteile und -anlagen, soweit sie nicht von den Nutzem selbst getragen werden oder in den vorgenannten Punkten
beinhaltet sind. 
  

	20.	Die Kosten für Wartungen 

 Hierzu gehören die Kosten für alle Wartungsarbeiten, die im Objekt durchgeführt werden und nicht in den vorgenannten Punkten beinhaltet sind. 

  
 Seite 15 des Mietvertrages
vom 21.12.2004 

  

	21.	Sonstige öffentliche Gebühren 

  

	22.	Die Kosten 

 des Betriebs

  

	 	a)	der Gemeinschafts-Antennenanlage bzw. 

  

	 	b)	der mit einem Breitbandkabelnetz verbundenen privaten Verteileranlage bzw. 

 

	 	c)	der Satellitenempfangsanlage 

  

	23.	Die Kosten für die Objektbewachung und Sicherheitseinrichtungen 

 Hierunter gehören die Kosten für regelmäßige und besondere Be- und Überwachungsmaßnahmen sowie die Kosten für Fertigung, Anbringung und Betrieb für
Sicherheitseinrichtungen. 
  

	24.	Die Kosten sonstiger Geräte 

 Hierzu gehören die Kosten des Betriebs z. B. maschineller Wasch- und Trockeneinrichtungen. 
  

	25.	Die Kosten der Mietnebenkostenkonten 

 Hierzu gehören die Kapitalkosten der Mietnebenkostenkonten, wie z. B. Bearbeitungsgebühren, Kontogebühren, Sollzinsen. 

 

	26.	Sonstige Betriebskosten 

Das sind die in den Nummern 1 bis 25 nicht genannten Betriebskosten, namentlich die Betriebskosten von Nebengebäuden, Anlagen und
Einrichtungen. 
  

					
	Essen, den 06.01.2005	 		 	Mannheim, den 22.12.04
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)
	 Alters- und Hinterbliebenen-Versorgungsstelleder

Technischen Überwachungs-Vereine (VVaG)
	 		 	
	Kurfürstenstraße 56 - 45138 Essen	 		 	

  
 Seite 16 des Mietvertrages
vom 21.12.2004 

  

 

 

  

  
 Nachtrag Nr. 1 zum
Mietvertrag vom 06.01.2005 / 22.12.2004 
 Objekt: Janus-Office-Center,

Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 
 Alters- und Hinterbliebenen Versicherung der 

Technischen Überwachungsvereine VVaG 

Kurfürstenstr. 56 
 45138 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 
 und 
 Firma 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 
 68167 Mannheim 
 vertreten durch den Geschäftsführer Herr Jochen Mattis 
 - nachstehend
Mieterin genannt 
  

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird um 57,65 m2 im 1. OG erweitert. Der Grundriss ist als Anlage 1 zum Nachtrag beigelegt. 
  

	3.	Änderung zu § 4 Mietzins, Nebenkosten und Mehrwertsteuer 

 Der Mietzins für das 1. OG setzt ab dem 01.02.2006 wie folgt zusammen: 
  

									
	Bürofläche seither	  	171,18 m2	  	x	  	[...***...]	  	[...***...]
	Bürofläche neu	  	57,65 m2	  	x	  	[...***...]	  	[...***...]
	4 Tiefgaragenstellplätze	  		  		  		  	[...***...]
	Nebenkostenvorauszahlung	  	228,83 m2	  	x	  	[...***...]	  	[...***...]
	Zwischensumme netto	  		  		  		  	[...***...]
	Mehrwertsteuer 16 %	  		  		  		  	[...***...]
	Summe brutto gesamt	  		  		  		  	[...***...]

  
  

***Confidential Treatment Requested 
  

			
	 Seite 1 des Nachtrags vom 07.12.2005
	  	

  

	4.	Sonstiges 

  

	 	1.	Der Vermieter übernimmt auf seine Kosten die Umverlegung der Strom- und Serverleitungen, sowie das Teppichverlegen der neu angemieteten Räume.

 Der Mieter übernimmt die Kosten der Verschiebung der Wande. 

 

	 	2.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den 30.01.06	 		 	Mannheim, den 13.01.06
			
	Alters- und Hinterbliebenen Versicherung	 		 	Fa. Nitec Pharma GmbH
	der Technischen Oberwachungsvereine VVAG	 		 	Joseph-Meyer-Str. 13-15
	Kurfürstenstr. 58	 		 	
	45138 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVAG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  
 Seite 2 des Nachtrags vom
07.12.2005 

  

 

 

  

  
 Nachtrag Nr. 2 zum
Mietvertrag vom 06.01.2005 / 22.12.2004 
 Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 
 Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 UST ID: DE 11 98 24807 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird ab 01.02.2007 um 214,17 m2 im 1. OG erweitert. Somit wird das komplette 1. OG von der Mieterin belegt. Die Gesamtfläche beträgt 443 m2. 
  

	2.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis veriängert sich ab 01.02.2007 für das komplette 1. OG um weitere 2 Jahre bis zum 31.01.2009 

 

	3.	Änderung zu § 5 Mietzins 

  

											
	 Kaltmiete Bürofläche 1. OG
	  	 	443 m2	  	  	á	  	[...***...]	  	[...***...]
	 Tiefgaragenplätze 125,126,127,128
	  				  		  		  	
	 Stellplätze Nr. 33+32
	  				  		  		  	[...***...]
		  				  		  		  	 
	 Summe Kaltmiete
	  				  		  		  	[...***...]
	 + Nebenkostenvorauszahlung
	  	 	443 m2	  	  	á	  	[...***...]	  	
		  				  		  		  	 
	 Summe Warmmiete netto

+ 19 % MwSt.
	  				  		  		  	[...***...]
		  				  		  		  	 
	 Summe gesamt
	  				  		  		  	[...***...]
		  				  		  		  	 

  
  

***Confidential Treatment Requested 
 Seite 1 des Nachtrags Nr. 2 AHV/Nitec 

  

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Verlegung der Strom- und Serverleitungen, sowie den Abbruch der eingezogenen Wand. 

 

	 	2.	Der Vermieter übernimmt die Kosten für das Verlegen von Teppich in den neu angemieteten Räumen. 

 

	 	3.	Sämtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

							
	Essen, den	 	  
	 		 	Mannheim, den 03. January 2007
			
	Alters- und Hinterbilebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine-VVaG-	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  
 Seite 2 des Nachtrags Nr. 2
AHV/Nitec 

  
 Nachtrag Nr. 3 zum
Mietvertrag vom 06.01.2005 / 22.12.2004 
 Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 
 zwischen 
 Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer. pol. G. Wiedemann und Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietgegenstand 

 Die Mietfläche wird ab 01.04.2008 um 247,29 m2 im 5. OG erweitert. 
 Somit beträgt die Gesamtfläche
neu 690,29 m2 (1. und 5. OG) 

 

	2.	Änderung zu § 5 Mietzins 

 Der Mietzins für setzt sich ab 01.04.08 wie folgt zusammen: 
  

																	
	 Kaltmiete Bürofläche 1. OG
	  	 	443,00 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
	 Kaltmiete Bürofläche 5. OG
	  	 	247,29 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
	 Tiefgaragenplätze 125,126,127,128,132,133
	  				  				  				  	 	[...***...]	  
	 Stellplätze Nr. 32+33+10+11+2
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe Kaltmiete
	  				  				  				  	 	[...***...]	  
	 + Nebenkostenvorauszahlung
	  	 	690,29 m2	  	  	 	á	  	  	 	[...***...]	  	  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe Warmmiete netto
	  				  				  				  	 	[...***...]	  
	 + 19 % MwSt.
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 
	 Summe gesamt
	  				  				  				  	 	[...***...]	  
		  				  				  				  	 	 	 

  
  

***Confidential Treatment Requested 
 Seite 1 des Nachtrags Nr. 3 AHV/Nitec 

  

	4.	Sonstiges 

  

	 	1.	Der Mieter übernimmt auf seine Kosten die Malerarbeiten und Teppichreinigung in den Büroräumen im 5 OG. 

 

	 	2.	In Büroräumen, in welchen der Teppichboden sehr stark abgenutzt ist, ersetzt der Vermieter den Teppichboden. 

 

	 	3.	Der Vermieter übernimmt die Kosten einer Geschirrspülmaschine. 

  

	 	4.	Die Möbel im 5. OG gehen kostenfrei auf die Firma Nitec Pharrna über. 

 

	 	5.	Samtliche übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 gelten unverändert fort. 

 

					
	Essen, den                     	 		 	Mannheim, den 04, April 2008
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Meiterin)

 Anlage I: Grundriss 5. OG 

Anlage II: Stellplatze Tiefgarage und Erdgeschoss 

  
 Seite 2 des Nachtrags Nr. 2
AHV/Nitec 

  

 

 

  
 Seite 3 des Nachtrags Nr. 2
AHV/Nitec 

  

 

 

  
 Seite 5 des Nachtrags Nr. 2
AHV/Nitec 

  

 

 

  
 Seite 6 des Nachtrags Nr. 2
AHV/Nitec 

  
 7.1.5 

Nachtrag Nr. 4 zum Mietvertrag vom 06.01.2005 / 22.12.2004 
 Objekt: Janus-Office-Center,
 Josef-Meyer-Str. 13-15, 68167 Mannheim

 Zwischen 
 Alters-und
Hinterbliebenen-Versicherung der 
 Technischen Überwachungs-Vereine VVaG 
 Kronprinzenstr. 30 
 45128 Essen 
 UST ID: DE 11 98 24807 
 Vertreten durch den Vorstand Herr Dr. rer. pol. G. Wiedemann und
Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 
 und 
 Firma 
 Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15 

68167 Mannheim 
 vertreten durch den
Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis verlängert sich für die gesamte angemietete Fläche bis zum 31.12.2010. 
  

	2.	Sonstiges 

 Sämtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 nebst allen Nachträgen gelten unverändert fort. 
  

					
	Essen, den 24.09.2008	 		 	Mannheim, den 18 SEPT 2008
			
	 Alters- und Hinterbliebenen-Versicherung der
 Technischen Überwachungs-Vereine VVaG
 Kronprinzenstr. 30
	 		 	 Fa. Nitec Pharma GmbH

Joseph-Meyer-Str. 13-15

			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)

  
 Seite 1 des Nachtrags Nr. 4
AHV/Nitec 

  
 Nachtrag Nr. 5 zum
Mietvertrag vom 06.01.2005/22.12.2004 
 Objekt: Janus-Office-Center, 

Josef-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 
 Alters- und Hinterbliebenen-Versicherung 

der Technischen Uberwachungs-Vereine VVaG 

Kronprinzenstr. 30 
 45128 Essen 

UST ID: DE 11 98 24807 
 Vertreten durch den
Vorstand Herr Dr. rer pol. G Wiedemann and Herr Ralf Heynck 
 - nachstehend Vermieter genannt - 

und 
 Firma 

Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15

 68167 Mannheim 
 vertreten durch
den Geshäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 

 

	1.	Änderung zu § 1 Mietsache 

 Die Mieterin mietet ab 01.04.2009 zusätzlich einen Lagerraum im Erdgeschoss an. 
  

	2.	Änderung zu § 5 Mietzins 

 Somit ended sich die monatliche Mietzahlung ab 01.04.09 wie folgt: 
  

											
	Kaltmiete Burof1äche 1. OG	  	443,00 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Kaltmiete Buroffäche 5 OG	  	247,29 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Lagerfläche EG	  	18,50 m2	 	á	  	[...***...]	  	[...***...]	  	€
	Tiefgaragenplätze 125,126,127,128,132,133	  		 		  		  	[...***...]	  	€
	Stellplatze Nr 32+33+10+11+2	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Kaltmiete	  		 		  		  	[...***...]	  	€
	+ Nebenkostenvorauszahlung	  	690,29 m2	 	á	  	[...***...]	  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe Warmmiete netto	  		 		  		  	[...***...]	  	€
	+ 19 % MwSt.	  		 		  		  	[...***...]	  	€
		  		 		  		  	 	  	
	Summe gesamt	  		 		  		  	8.910,55	  	€
		  		 		  		  	 	  	

  
  

***Confidential Treatment Requested 

  

	3,	Sonstiges 

 Samtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01 2005/ 22 12.2004 nebst allen Nachirägen gelten unverandert fort 
  

					
	Essen, den 12.3.09	 		 	Mannheim, den 12.03.09
			
	Alters- und Hinterbliebenen-Versicherung der	 		 	Fa. Nitec Pharma GmbH
	Technischen Überwachungs-Vereine VVaG	 		 	Joseph-Meyer-Str. 13-15
	Kronprinzenstr. 30	 		 	
			
	45128 Essen	 		 	68167 Mannheim
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieterin)	 		 	(Mieterin)
	Alters- und Hinterbliebenen-Versicherungder Technischen Überwachungs-Vereine (VVaG)	 		 	
	Kronprinzenstr. 30 45128 Essen	 		 	

  
 Seite 2 des Nachtrags Nr. 5
AHV/Nitec 

 Nachtrag Nr. 6 zum Mietvertrag vom 06.01.2005 / 22.12.2004 

Objekt: Janus-Office-Center, 
 Josef-Meyer-Str. 13-15, 68167 Mannheim 
 Zwischen 

Alters- und Hinterbliebenen-Versicherung der 

Technischen Überwachungs-Vereine-VVaG- 

Kurfürstenstr. 56, 45128 Essen 
 UST ID: DE
11 98 24807 
 Vertreten durch den Vorstand Herr R Heynck und Frau S. Schwierz 
 - nachstehend Vermieter genannt - 
 und 
 Firma 
 Horizon Pharma GmbH 
 ehemals Fa. Nitec Pharma GmbH 
 Joseph-Meyer-Str. 13-15, 68167 Mannheim 

vertreten durch den Geschäftsführer Herr Dr. Achim Schäffler 
 - nachstehend Mieterin genannt - 
 Präambel 

Die Fa. Nitec Pharma GmbH wurde am 22.06.2010 in Horizon Pharma GmbH umbenannt. Sämtliche Rechte und Pflichten aus dem bestehenden Mietvertrag gehen
somit zeitgleich auf die Firma Horizon Pharma GmbH über. 
  

	1.	Änderung zu § 4 Mietzeit und Kündigung 

 Das Mietverhältnis verlängert sich für die gesamte angemietete Fläche bis zum 31.12.2011. 
  

	2.	Sonstiges 

 Sämtliche
übrigen Bestimmungen des Hauptmietvertrags vom 06.01.2005/ 22.12.2004 nebst allen Nachträgen gelten unverändert fort. 
  

									
	 Essen, den
	  	26.8.2010	  		  	Mannheim, den	  	19.Aug.2010
			
	 Alters- und Hinterbliebenen-Versicherung der

Technischen Überwachungs-Vereine VVaG

Kronprlnzenstr.30
  

45128 Essen
	  		  	 Fa. Horizon Pharma GmbH
 Joseph-Meyer-Str. 13-15
  

68167 Manneheim

			
	 /s/ illegible
	  		  	/s/ Achim Schäffler
	 (Vermieterin)

Alters- und Hinterbliebenen-Versicherung der Technischen Überwachungs-Veriene (VVaG) Kurfürstenstr. 56 • 45138
Essen
	  		  	 (Mieterin)

  

							
	 Seite 1 des Nachtrags Nr. 6 AHV/Horizon

Sitz: München

Amtsgericht München HRB 89 260

HypoVereinsbank München 2 450 577

BLZ 700 202 70
 USt-IdNr. DE129484259
 Informationen gemäß
§ 2 Abs. 1 DL-InfoV
 unter www.tuev-sued.de/impressum
	 	 Geschäftsführer:
 Dipl.-Ing. Wolfgang Berger
 690580 v2/SD
	 	Telefon: +49 711 7005-211
 Telefax: +49 711 7005-312

www.tuev-sued.de
 TÜV®
	 	TÜV SÜD Immobilien Service GmbH

Gottlieb-Daimler-Straße 7
 70794
Filderstadt
 Deutschland

  
 7.1.4 

Mietvertrag über 
 Stellplätze 
 Joseph-Meyer-Str. 13-15, 68167 Mannheim 

Zwischen 
 Alters-und Hinterbliebenen

 Versicherung der 
 Technischen
Uberwachungsvereine VVaG 
 Kurfurstenstr. 56 
 45138 Essen 
 UST ID: DE 11 98 24807 
 Vertreten durch den Geschf. Vorstand Herr Dr. rer. Pol. G. Wiedemann 
 und 

Firma 
 Nitec Pharma GmbH 

Joseph-Meyer-Str. 13-15 
 68167 Mannheim

 vertreten durch den Geschaftsführer Herr Jochen Mattis 
 -nachstehend Mieterin genannt- 
  

	1.	Mietobjekt 

 Der Mieter
mietet ab 01.08.2007 in der Joseph-Meyer-Str. 13-15, 68167 Mannheim nachstehende Stellpätze an: 
  

							
	Stellplatz Nr. 10+11	  	á	  	[...***...]	  	[...***...]
	+ 16% MwSt.	  		  		  	[...***...]
		  		  		  	 
	monatliche Stellplatzmiete gesamt	  		  		  	[...***...]

  

	2.	Kündigung 

Der Mietvertrag kann von beiden Parteien mit einer Frist von 1 Monat gekündigt werden. 

  
  

***Confidential Treatment Requested 

  

					
	Filderstadt, den 07.08.07	 		 	Mannheim, den [Illegible]
			
	TUV SUD Immobillien Servico GmbH	 		 	 Nitec Pharma GmbH

Joseph-Meyer-Strafle 13-15
 68167
Mannheim

	[Illegible]	 		 	
			
	 [Illegible Signature]
	 		 	 [Illegible Signature]

	(Vermieter)	 		 	(Mieter)

  
 2.Packaging and Supply Agreement, dated September 19, 2008

 Exhibit 10.25 
 ***Text Omitted and Filed Separately 
 with the Securities and
Exchange Commission. 
 Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(b)(4) 
 and 230.406. 
 Execution Version 

PACKAGING and SUPPLY AGREEMENT 
 for the packaging of pharmaceuticals between 
 NITEC PHARMA AG, Kaegenstrasse 17, CH-4153
Reinach, Switzerland, hereinafter referred to as “NITEC” and 
 CATALENT GERMANY SCHORNDORF GmbH Steinbeisstraße
2, D-73614 Schorndorf, Germany, hereinafter referred to as “CATALENT” and made effective 29 Sept. 2008, (the “Effective Date”). 
 WHEREAS, NITEC is a company manufacturing, distributing and licensing pharmaceutical products, including LODOTRATM prednisone (Presentations in accordance with Appendix 1), and is
interested in having CATALENT package LODOTRA for use, marketing, distribution and sale by NITEC or a third party. 
 WHEREAS, CATALENT
has extensive experience in and maintains adequate facilities and personnel for contracting services related to the packaging of pharmaceuticals (“Services”) in accordance with Appendix 7. 

WHEREAS, the Parties wish to enter into a close relationship in respect of CATALENT’s assembly of NITEC’s LODOTRA (as more specifically
described in Appendix 1) and its supply to NITEC to the effect that both Parties will obtain maximum economic benefits from their cooperation. 
 WHEREAS, NITEC and CATALENT shall enter into a separate quality agreement (the “Quality Agreement”) governing the quality issues of CATALENT’s Services for NITEC. 

WHEREAS, the Parties wish to have all commercial issues of CATALENT’s Services for NITEC governed by this Agreement. 

Now, therefore, the Parties agree as follows: 
 ARTICLE 1 - SUBJECT OF THE AGREEMENT 
 1. The subject matter of this Agreement is the
packaging of LODOTRA as set forth in Appendix 2 (hereinafter referred to as “Packaging Requirements”) at prices and conditions set forth in Appendix 3 (hereinafter referred to as “Prices”), and the
delivery of such finished products (hereinafter referred to as “Finished Product”) to NITEC or such other destinations as NITEC may request, and Catalent may agree in writing, as provided for in the Quality Agreement. 

2. CATALENT acknowledges that partners or affiliated companies of NITEC might be interested in the future to become a Party of this Agreement. CATALENT
therefore agrees that - subject to the execution of a respective amendment to this Agreement - partners or affiliated companies of NITEC shall upon agreement of the Parties become a Party to this Agreement. 

3. CATALENT acknowledges that assembly of LODOTRA on CATALENT’s site at Schorndorf is of utmost importance for the performance of this Agreement.
CATALENT 
  

					
	10 Sept 2008	  	1.	  	

 Execution Version 
  
 
therefore accepts that it may not render its Services from a different site without NITEC’s prior written consent. 
 ARTICLE 2 - DELIVERY OF NITEC PRODUCT LODOTRA 
 1. NITEC shall deliver to CATALENT, at
NITEC’s own expense and risk of loss, tablets of LODOTRA DDP (Incoterms 2000), CATALENT’s facility in Schorndorf as specified in Appendix 1 and the Quality Agreement in order to enable CATALENT to render the Services. 

2. The Parties accept the likelihood of minor losses of tablets of products when comparing the amount of tablets shipped by NITEC to CATALENT and the
amount of tablets as Finished Product delivered from CATALENT to NITEC or its partners. Therefore, the Parties expressly agree that, upon the first anniversary of the date of this Agreement, they shall mutually agree on a reasonable loss rate. NITEC
further acknowledges that any broken or non-conforming tablets of LODOTRA shall not be included in the calculation of such loss rate. CA TALENT shall reimburse NITEC for losses only in the event its losses exceed the reasonable loss mutually agreed
between the Parties. 
 ARTICLE 3 - FORECAST AND DELIVERY 
 1. The average quantities for each of NITEC’s individual orders for Finished Product are specified in Appendix 4. 
 2. During the term of this Agreement, NITEC shall make available to CATALENT an [...***...] rolling forecast of its requirements of Finished Product which shall be updated by NITEC every
[...***...]. Only the [...***...] of such rolling forecast shall be binding for NITEC and result in separate firm purchase orders. The volumes specified for the other [...***...] of such rolling forecast shall be non-binding
estimates only. 
 3. NITEC shall send orders to CATALENT for Finished Product and, subject to CATALENT’s written confirmation, CATALENT
shall deliver the Finished Product ordered Ex Works (Incoterms 2000), CATALENT’s facility within a period of [...***...] after receipt of confirmation of NITEC’s purchase order. Subject to CATALENT’s written confirmation as set
forth above, CATALENT shall use its commercially reasonable efforts to fulfil purchase orders for Finished Product. In the case of orders exceeding the volumes specified in NITEC’s forecasts for its binding period of [...***...] by up to
[...***...] CATALENT will use commercially reasonable efforts to fulfill this exceeding request within the [...***...] in which the original order was placed. CATALENT shall use commercially reasonable efforts to fulfill purchase orders
for Finished Product exceeding the volumes specified in NITEC’s forecast by more than [...***...]. NITEC undertakes to notify CATALENT in writing of its exceeding requirements for Products as early as reasonably possible. 

4. CATALENT shall be responsible for the order and the purchase of raw materials and packaging materials, except primary packaging material (collectively
“Materials”), from third parties as it deems appropriate. NITEC shall be responsible for firmly ordering primary packaging material (“Primary Packaging Materials”) from [...***...] or any other supplier chosen
by NITEC in accordance with NITEC’s rolling forecast and the contract 
  

					
	10 Sept 2008	 	2.	 	***Confidential Treatment Requested

 Execution Version 
  
 
between NITEC and [...***...] a copy of which is attached as Appendix 6 and shall arrange for the delivery of such Primary Packaging Materials DDP (Incoterms 2000), CATALENT’s
facility; provided, however, as set forth in Article 13.3, NITEC shall not hold CATALENT responsible or make a claim against CATALENT if a delay is attributable to [...***...] or the respective supplier’s failure to deliver
the Primary Packaging Materials properly or in a timely manner. In no event, however, shall NITEC be obliged to purchase from CATALENT Materials or otherwise pay for Materials, which exceed the amount necessary to comply with NITEC’s
requirements of Finished Products set out in the binding part of the rolling forecast (which is the first three months). 
 5. In the event that
CATALENT becomes aware of circumstances (including Force Majeure circumstances) that may cause a delay in the delivery of Finished Product, CATALENT shall notify NITEC immediately. CATALENT shall use commercially reasonable efforts to avoid any
delay in delivery and, if such delay cannot be avoided, shall minimize and afford to NITEC its full co-operation to minimize the effects of delay for NITEC. Further, the Parties, shall as soon as feasible after the execution hereof, mutually prepare
a crisis management plan setting out its strategies and solutions in the event of CATALENT’s inability to fullfil its contractual obligations. 
 6. It is expressly understood that CATALENT’s obligations pursuant to Article 3.5 is conditional upon NITEC’s delivery of tablets of LODOTRA, as set forth in Article 2 and the Quality Agreement,
and NITEC’s (or a third party’s) delivery of Primary Packaging Material as set forth in Article 3.4 at least two (2) weeks prior to the confirmed date of starting the Services. 

ARTICLE 4 - CONTINUOUS IMPROVEMENT PROGRAMME 
 1. The Parties shall hold Continuous Improvement Programme (“CIP”) meetings at appropriate intervals to identify and implement ways and means by which they can continually improve
quality, time and cost of the Finished Product and Services supplied hereunder. 
 2. A set of reasonable continuous improvement objectives
(e.g. optimisation of yield losses) shall be mutually agreed for each calendar year starting after one year of first commercial production. At the end of such year, CATALENT and NITEC shall review the CIP and measure the achievement of the CIP
objectives by CATALENT. 
 ARTICLE 5 - PRICES AND CONDITIONS 
 1. The prices and conditions set forth in Appendices 2 and 3 shall apply to the Services during the first year of this Agreement. Thereafter, the Parties shall review the price structure and
mutually agree on any fair and reasonable adjustments to the prices taking into particular consideration, the principles set forth in Articles 5.2 and 5.3, below. 
 2. NITEC or CATALENT may request that the prices for the Services be adjusted in accordance with the calculation set out in Appendix 3 if: (i) [...***...]; or
(ii) [...***...]; or (iii) if NITEC requests a change in the Services to which CATALENT agrees. 
  

					
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 3. NITEC shall pay CATALENT’s invoices within [...***...] of the date of invoice, net. Late payments
shall be subject to a surcharge of [...***...] on all overdue accounts. All payments shall be made in Euros. 

ARTICLE 6 - REPRESENTATIONS AND WARRANTIES 
 1. Each Party hereby represents and warrants to the other Party that such Party (i) is duly organized and validly existing under the laws of the jurisdiction in which it is organized, (ii) has
the power and authority and the legal right to own and operate its property and assets, and to carry on its business as it is now being conducted, and (iii) is in compliance with all requirements of any applicable laws, except to the extent
that any non-compliance would not adversely affect such Party’s ability to perform its obligations under this Agreement. 
 2. Each Party
hereby represents and warrants to the other Party that such Party (i) has the power and authority and the legal right to enter into this Agreement and to perform its obligations hereunder, (ii) has taken all necessary action on its part to
authorize the execution and delivery of this Agreement and the performance of its obligations hereunder, and (iii) this Agreement has been duly executed and delivered on behalf of such Party, and constitutes a legal, valid, binding obligation,
enforceable against such Party in accordance with its terms. 
 3. NITEC represents and warrants that (i) all material (content of
packaging insert, promotional material and the LODOTRA) delivered to CATALENT shall comply with all applicable laws governing their manufacture, use, promotion, sale and distribution; (ii) NITEC has obtained all permits, licenses or
authorizations from all relevant regulatory agencies necessary or required for the manufacture and possession of LODOTRA and for its use as set forth in the respective order; (iii) NITEC will not use LODOTRA nor any other material supplied by
NITEC for any clinical study, sale, marketing or any commercial activity without ensuring that it has obtained all permits, licenses or authorizations from all relevant regulatory agencies; (iv) NITEC acknowledges that it will review all
packaging inserts as well as labels, drawings and artwork and that all such material is subject to NITEC’s approval; and (v) NITEC has provided to CATALENT all available safe handling instructions, health and environment information and
material safety data sheets applicable to LODOTRA and any other materials supplied by NITEC. 
 4. CATALENT represents and warrants that all
Services rendered and all Finished Product delivered to NITEC hereunder will be in full conformance with cGMP rules, applicable local requirements and all Specifications agreed and the Quality Agreement; provided, however, CATALENT shall not
be held liable and NITEC shall not make a claim for any non-conformity attributable to NITEC-supplied materials (including, but not limited to, the LODOTRA, artwork, packaging inserts and labeling). 

5. NITEC or its partners shall inspect each shipment of Finished Product for obvious defects and completeness within [...***...] after receipt of
each delivery and NITEC shall notify CATALENT in writing immediately of any defects or shortages it has discovered. § 377 HGB (German Commercial Code) shall not apply. 
 6. In the event of hidden defects not readily ascertainable upon inspection per Article 5.5 above, the Party that first becomes aware of the defect shall notify the other Party of any such defect
immediately, but in no event later than within [...***...], after they have been 
  

					
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discovered which for the purposes of the Agreement shall not be more than [...***...] after completion of the Services. 
 7. If Finished Product delivered hereunder does not fully comply with the warranties given by CATALENT in Article 6.4 (“Defective Products”), NITEC may, subject to Article 9, submit
within a period of [...***...] either a demand for replacement of the Defective Products at no additional charge for the Services (if and to the extent the defect is directly attribute to CATALENT’s gross negligence (Grobe
Fahrlässigkeit) or willful misconduct) for Finished Product of proper quality or rectification of the Defective Products or a credit corresponding to the invoiced amount for the Defective Products. In the event CATALENT is required to
replace Defective Product, CATALENT shall replace Defective Product with conforming Product, provided that in such event, NITEC shall supply, at its cost and expense, the LODOTRA and any other materials supplied by NITEC necessary to replace the
Defective Product. Conversely, any cost and expenses related to the Defective Product incurred by CATALENT and/or NITEC, including but not limited to the costs and expenses for full replacement (also in the case of hidden defects) and/or destruction
of Defective Product shall be borne by CATALENT (whereby the cost of LODOTRA shall be set out in Appendix 8) only if and to the extent the defect is directly attributable to CATALENT’s gross negligence or willful misconduct. 

8. If there is a dispute whether a Finished Product delivered is a Defective Product or whether a Finished Product’s defect has been caused by
CATALENT or by NITEC after receipt, a sample of the rejected Finished Product and a sample retained by CATALENT shall be exchanged between the Parties for analysis. If the Parties fail to come to a mutually satisfying conclusion within a period of
[...***...] following the exchange of the samples, both samples shall be submitted to a laboratory acceptable to both Parties as agreed case by case (the “Laboratory”). The Laboratory shall determine whether the rejected
Finished Product is defective and thereafter, to which Party such defect is to be attributed, and its determination, in the absence of manifest error, shall be final and binding upon the Parties. The costs charged by the Laboratory shall be borne by
the Party that has been found to be wrong by the Laboratory’s determination. 
 9. THE OBLIGATIONS OF CATALENT TO REPLACE OR RECTIFY
DEFECTIVE PRODUCT IN ACCORDANCE WITH ARTICLE 6.7 SHALL BE NITEC’S SOLE AND EXCLUSIVE REMEDY FOR DEFECTIVE PRODUCT AND IS IN LIEU OF ANY OTHER WARRANTY, EXPRESS OR IMPLIED. 
 ARTICLE 7 - RECALL OR WITHDRAWAL OF FINISHED PRODUCT 
 1. In the event that either Party is
of the opinion that a recall or product withdrawal of the Finished Product should be considered, such Party shall immediately inform the other Party and the Marketing Authorisation Holder (MAH) for the Finished Product in writing (including telefax)
of such conclusion. The further procedure and in particular all communication shall be coordinated by NITEC’s European Qualified Person (QP)/Pharmacovigilance in coordination with the QP of the Manufacturer and the concerned national QPs for
Pharmacovigilance of the other involved Parties. A final decision on a recall or product withdrawal will be made by NITEC’s committee for crisis management and executed by the relevant MAH. 

 

					
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 2. CATALENT shall not take any action, other than action which it is required to take by law, without first obtaining the
approval of NITEC’s QP. 
 3. In conjunction with such recall, each Party shall assist each other in the investigation to determine the
cause and extent of the problem and the Parties shall fully cooperate with each other concerning the necessity and nature of such action. Depending on the nature of such an event the Parties agree to find a consensus in due time. 

4. In the event that any Finished Product is recalled because it does not conform to the warranties set forth in Article 6 and NITEC or a third party is
responsible for such non-conformity, or because NITEC was negligent or intentionally acted wrongfully, or due to an omission of NITEC, NITEC shall bear the costs and expenses incurred directly from such recall, including without limitation, expenses
related to communications and meetings with all required regulatory agencies, expenses of replacement stock, the cost of notifying customers and costs associated with shipment of recalled Finished Product from customers and shipment of an equal
amount of replacement Finished Product to those same customers. Conversely, in the event that any Finished Product is recalled because it does not conform to the warranties set forth in Article 6 and CATALENT is responsible for such non-conformity,
or because CATALENT was negligent or intentionally acted wrongfully, or due to an omission of CATALENT, CATALENT shall, subject to Article 9, bear the direct administrative costs and expenses incurred directly from such recall, as approved by
CATALENT in writing in advance. 
 5. In the event that CATALENT becomes knowledgeable of any pharmaceutical technical complaint or an adverse
reaction related to the product, the NITEC QP Pharmacovigilance should be immediately informed. 
 ARTICLE 8 - INDEMNIFICATION

 1. Subject to Article 9, each Party shall be liable to the other Party for all damages arising for the other Party out of the breach of
any obligation of the breaching Party under this Agreement. 
 2. Subject to Article 9, each Party (the “Indemnifying Party”)
shall indemnify and hold the other Party (the “Indemnified Party”) harmless for third party claims and all related costs, expenses, liabilities, damages, losses and fees, (including reasonable legal and other reasonable professional
fees and costs) (“Liability”) arising out of or resulting from the Indemnifying Party’s breach of this Agreement or any negligent, willful misconduct or other wrongful act or omission directly attributable to the Indemnifying
Party in connection with this Agreement. 
 3. In addition to Article 8.2, NITEC shall indemnify and hold harmless CATALENT, its affiliates, and
their respective directors, officers, employees, and agents from and against any and all losses arising out of or resulting from (A) any breach of its representations, warranties or obligations set forth in this Agreement; (B) any
manufacture (other than the negligently performed Services), sale, promotion, distribution, use of or exposure to the LODOTRA or any materials supplied by NITEC, including, without limitation, product liability or strict liability;
(C) NITEC’s exercise of control over the Services to the extent that NITEC’s instructions or directions violate applicable laws; (D) any actual or alleged infringement or violation of any patent, trade secret, copyright,
trademark or other proprietary rights provided 
  

					
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by NITEC; or (E) any negligence or willful misconduct of NITEC, except to the extent that any of the foregoing arises out of or results from CATALENT’s negligence, willful misconduct,
or breach of this Agreement. 
 4. Upon receiving notice of any claim for Liability under this provision, such Party shall promptly notify the
Indemnifying Party in writing with full details of the claim; provided, however, that failure to give notice shall not limit or otherwise reduce the indemnification provided for in this Agreement except to the extent the delay or
failure to give notice materially impairs the defence of such claim for Liability. Regardless, unless made with the express prior written consent of the Indemnifying Party, no sums paid by the Indemnified Party in settlement of any lawsuit shall be
recoverable under this provision. Conversely, under no circumstances shall the Indemnifying Party settle any claim or admit wrongdoing or liability of the Indemnified Party without the Indemnified Party’s express prior written consent.

 ARTICLE 9 - LIMITATION OF LIABILITY 
 1. IN NO EVENT SHALL THE LIABILITY OF CATALENT UNDER THIS AGREEMENT [...***...]. 
 2.
NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY INCIDENTAL, INDIRECT OR CONSEQUENTIAL DAMAGES OF ANY KIND, INCLUDING BUT NOT LIMITED TO, LOST PROFITS, LOST DATA, LOST REVENUES AND/OR LOSS OF BUSINESS OPPORTUNITY. 

3. To the extent that any provision in this Agreement or any order purporting to limit either Party’s liability to the other Party or either
Party’s remedies (any such provision a “Limiting Provision”) violates or contradicts any law deemed by the final, non-appealable order of a court or other body of competent jurisdiction to govern any dispute (any such law a
“Mandatory Applicable Law”) such Limiting Provision shall not apply, but shall instead be replaced by (and only to the extent of) the applicable provisions of such Mandatory Applicable Law solely for the purposes of resolving such
dispute. In particular, nothing in this Agreement or any order shall limit a Party’s liability for death or personal injury arising from its own negligence or for strict liability for defective products if such limitation would violate a
Mandatory Applicable Law. 
 ARTICLE 10 - INSURANCE 
 1. CATALENT shall, at its own cost and expense, obtain and maintain in full force and effect the following insurance during the term of this Agreement, each covering claims brought and suits served
anywhere in the world: 
  

	 	(a)	Commercial General Liability (Haftpflichtversicherung) or Public Liability insurance (whichever is applicable) with per-occurrence and general aggregate limits
of not less than [...***...]; 

  

					
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	 	(b)	Products and Completed Operations Liability Insurance with per-occurrence and general aggregate limits of not less than [...***...]; 

 

	 	(c)	Professional Services Errors & Omissions Liability Insurance with per claim and aggregate limits of not less than [...***...] covering sums that CATALENT
becomes legally obligated to pay as damages resulting from claims made by NITEC for errors or omissions committed in the performance of the Services set forth in the Agreement. 

 In the event that any of the required policies of insurance are written on a claims made basis, then such policies shall be maintained during the entire teen of this Agreement and for a period of not
fewer than [...***...] following the termination or expiration of this Agreement. Each insurance policy that is required under this Article 10.1 shall be obtained from an insurance carrier with an A.M. Best rating of at least A- VII.

 CATALENT shall furnish evidence of insurance for the required policies to NITEC as soon as practicable after entering into this Agreement and
upon renewal of any such policies or upon the respective policy renewal becoming effective. 
 2. NITEC shall, at its own cost and expense,
obtain and maintain in full force and effect the following insurance during the term of this Agreement, each covering claims brought and suits served anywhere in the world: 

 

	 	(a)	Commercial General Liability Insurance as Marketing Authorization Holder(s) as per the applicable pharmaceutical laws and legacy of the individual countries or markets
when and where a Market Authorization for LODOTRA Tablets has been granted, e.g. in Germany with a general aggregate limit of an amount equivalent to not less than [...***...]; provided, however, this sub-section (a) shall not
apply to the United States and NITEC and CATALENT shall negotiate in good faith the Commercial General Liability Insurance to be procured and maintained by NITEC before LODOTRA is launched in the United States. 

 

	 	(b)	Commercial General Liability (Haftpflichtversicherung) or Public Liability insurance (whichever is applicable) with per-occurrence and general aggregate limits
of not less than [...***...]. 

  

	 	(c)	All Risk Property insurance, including transit coverage, in an amount equal to full replacement value covering NITEC’s property while it is at CATALENT’s
facility, or in transit to and from CATALENT’s facility, whereby any claim for recovery shall be made under NITEC’s insurance policy before a claim is made under CATALENT’s respective policy; provided, however, NITEC
acknowledges that neither CATALENT nor CATALENT’s insurance (if any) shall be responsible for, or liable for any costs, expenses, or losses that may occur during transit to or from CATALENT’s facility. 

In the event that any of the required policies of insurance are written on a claims made basis, then such policies shall be maintained during the entire
term of this Agreement and for a period of not fewer than [...***...] following the termination or expiration of this 

 

					
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Agreement. Each insurance policy that is required under this Article 10.2 shall be obtained from an insurance carrier with an A.M. Best rating of at least A- VII. 

NITEC shall furnish a certificate of insurance for the required policies to CATALENT as soon as practicable after entering into this Agreement and upon
each renewal of any such policies becoming effective. 
 ARTICLE 11 - CONFIDENTIALITY 

1. The recipient of any information provided by the other Party as a result of the operation of or in connection with this Agreement or its preparation,
negotiation or termination shall treat such information in confidence and shall not use or disclose such information to any third party except for the purposes of this Agreement. The same applies to the contents of this Agreement. 

2. The aforesaid does not apply to any information which (a) is or later comes into the public domain otherwise than by breach of this Agreement, or
(b) is in the possession of the Party receiving the information prior to its receipt under this Agreement, or (c) is independently received from a third party, which is free to disclose the information. 

3. The obligations set forth in this Article 11 do not prevent the disclosure of information to the competent authorities or agencies, in particular
judicial or administrative agencies, if required by law, but such disclosure shall be strictly limited to the extent of the disclosure required by the relevant authority or agency. In such event, the Party making the disclosure is required to give
prior written notice to the other Party and authorize it to seek an appropriate preventive solution. 
 4. All confidential information shall
remain the sole property of the Party disclosing such information or data. Upon termination of this Agreement, the receiving Party shall, promptly return within thirty (30) days all such information, including any copies thereof, and cease its
use or, at the request of the disclosing Party, shall promptly destroy the same and certify such destruction to the disclosing Party. 
 ARTICLE 12 - TERM OF AGREEMENT 
 1. The Agreement shall come into force upon its Effective
Date and shall remain in effect for a period of three (3) years after the launch of LODOTRA in the EU or in the United States, whichever comes first (the “Initial Period”). After the expiry of the Initial Period the Agreement shall be
extended automatically for further [...***...] renewal periods (if any, the “Renewal Periods”)(the Initial Period and any Renewal Periods will be the “Term”) unless either Party gives at least [...***...] months
written notice to terminate the Agreement before expiry of the then current period. Such termination shall not apply to any then-outstanding orders. 
 2. The right to terminate the Agreement for cause is reserved. In particular, terminations for cause are constituted by a gross failure to fulfil contractual obligations by either Party. Without
limitation to the generality of the foregoing, a gross failure on the part of CATALENT shall be deemed to have occurred if CATALENT delivers Finished Product that does not conform to the cGMP (or that would hinder the commercialisation of the
Finished 

  

					
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Product) more than [...***...] consecutive orders during a [...***...] period, or more than [...***...]. 
 3. NITEC may terminate this Agreement if NITEC or one of its partners decide to perform the assembly of LODOTRA at NITEC’s partner or within the NITEC group, whereby such termination shall be
effective upon NITEC giving CATALENT at least [...***...] written notice. In the event that NITEC terminates this Agreement pursuant to this Article 12(3), NITEC shall pay CATALENT all fees for Services rendered to the effective date of
termination in accordance with the applicable order, including any non-cancelable obligations, works-in progress and materials ordered by CATALENT for the performance of Services under this Agreement as warranted by NITEC’s forecasts, plus all
out-of-pocket expenses incurred by CATALENT on behalf of NITEC in connection with or as a result of such termination. CATALENT shall provide NITEC with an invoice for its termination expenses and charges under this Article 12.3 as soon as reasonably
practicable following termination of this Agreement. 
 ARTICLE 13 - FINAL PROVISIONS 

1. If changes in the market lead to a situation, which is not reasonable for either Party, both Parties will endeavour amicably to find a solution
acceptable to both of them. The same applies if disputes arise from the performance of the Agreement. 
 2. Except as set forth in Article 6.8
all disputes, controversies, or differences which may arise between the Parties out of or in relation to or in connection with this Agreement shall be decided by the courts of Mannheim (if NITEC is the defendant) and Schorndorf (if CATALENT is the
defendant). 
 3. Delay in or failure to carry out the obligations imposed on any Party under this Agreement shall not be deemed breaches of the
Agreement if such delay or failure results from fire, explosion, labour dispute, natural disaster, war, legislative or governmental acts, or any other cause beyond the control of the affected Party, including for example, if [...***...], or
any other supplier, or the respective legal successor (see Article 3.4), fails to delivery the Primary Packaging Materials properly or in a timely manner, in each case through no fault or negligence of the Party invoking these circumstances as an
excuse (collectively “Force Majeure”). Except with respect to [...***...] or any other supplier nominated by NITEC, or the respective legal successor, A lack or failure of the affected Party’s sub-contractor shall not
constitute Force Majeure unless caused by circumstances which represent Force Majeure themselves. In the event delay or failure due to Force Majeure continues for a period exceeding nine (9) months, either Party may terminate this Agreement
effective immediately. 
 4. If individual provisions of this Agreement are invalid or become invalid, the Parties hereby agree that this shall
not affect the validity of the remainder. The Parties undertake to replace the invalid provisions by others with the same economical effect as far as legally possible. 
 5. This Agreement including its Appendices 1 to 8 constitutes the entire agreement between the Parties concerning the subject matter. 

  

					
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 6. Any alterations of or additions to this Agreement or its Appendices must be made in writing and agreed to by both Parties.
This requirement shall also apply to the preceding sentence. 
 7. This Agreement is and any confirmed order placed under this Agreement is
subject to German law without its provisions regarding the conflict of laws or the Vienna Convention on the International Sale of Goods (CISG). 

8. The rights and obligations of the Parties shall continue under Articles 8 — 11, 12.3, 13.7 and 13.8 notwithstanding expiration or termination of
this Agreement. 
  

					
	 CATALENT GERMANY SCHORNDORF GmbH
  

29. Sept. 2008
	 		 	
			
	 /s/ Ronan Fox
	 		 	 /s/ Jürgen Hess

	by: Ronan Fox	 		 	by: Jürgen Hess
	its: Managing Director	 		 	its: Director Sales & BD

  

					
	 NITEC PHARMA AG
  

29. Sept. 2008
	 		 	29.9.08
			
	 /s/ Achim Schäffler
	 		 	 [Illegible Signature]

	by: Dr. Achim Schäffler	 		 	by: [Illegible]
	its: Head R&D & Prod. and Member of Board of Directors	 		 	

  

					
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 List of Appendices 

Appendix 1 — LODOTRA Presentations 

Appendix 2 — Packaging Requirements 

Appendix 3 — Prices and Price Re-Calculation 

Appendix 4 — Average quantities 
 Appendix 5
— Delivery sites 
 Appendix 6 — Copy of Agreement [...***...] and NITEC 
 Appendix 7 — Services 
 Appendix 8 — Costs of LODOTRA 

 

					
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 Appendix 1 — LODOTRA presentations 
 Lodotra 1 mg: 
 Each modified-release tablet contains 1 mg of prednisone

 Lodotra 2 mg: 
 Each modified-release tablet contains 2 mg of prednisone 
 Lodotra 5 mg:

 Each modified-release tablet contains 5 mg of prednisone 

 

					
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 Appendix 2 — Packaging Requirements [...***...] 

[...***...] 
 [...***...] 
 [...***...] 

[...***...] 
 [...***...]

 [...***...] 

[...***...] 
  

					
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 Appendix 3 – Prices 
 [...***...] 
  

					
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 Appendix 4—Average quantities (by NITEC)

  

													
	 Lodotra
	  	
[...***...]
	  	
[...***...]

	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]

  

					
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 Appendix 5 – Delivery Sites 
 (by NITEC) 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
 [...***...] 
  

					
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 Appendix 6 - Copy of Agreement between [...***...] and NITEC 

[Please see attached.] 
  

					
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 Exclusive Supply Agreement -
Pharmaceutical Plastic Packaging 
 Supply agreement commenced 15 October 2007 

between 
 BUYER,

 Nitec Pharma AG 
 KägenstraBe 9 
 CH-4153 Reinach 

Switzerland 

(hereinafter referred to as NITEC) 
 and 
 SELLER, 

Gerresheimer Værløse A/5 
 Walgerholm 2-8, 3500 Værlose, 
 Denmark, 

(hereafter referred to as Gerresheimer) 
 represented by Division President Niels Düring. 
  

	1.	Subject of Agreement 

 NITEC wishes to
enter into an agreement with Gerresheimer to buy “Products” from Gerresheimer listed under section 2 and specified under schedule 3 for the packaging of NITEC’s product LODOTRA, a novel modified release tablet containing prednisone.

 Purpose and objective of this agreement is to establish a long term partnership between NITEC and Gerresheimer. 

  

					
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 It is the intention that NITEC and Gerresheimer
shall pursue a consolidation of the respective businesses under a win-win philosophy, where both part are considered, preferred supplier and customer (Key Account), respectively. Gerresheimer agrees to exclusively supply NITEC with its DUMA Multi
Grip Cap –Art. No. 003424-3000- for NITEC’s LODOTRA. 
 This agreement will set the frame for this partnership and the background
for this project is to include the Duma Multi Grip packaging concept on LODOTRA packed in containers, enabling a clear and uniform communication platform to the end-user creating preference for NITEC’s LODOTRA with a packaging awarded, easy to
open packaging. 
 Furthermore, this agreement specifies the respective pharmaceutical responsibilities related to the manufacture and control
of the “Products”, especially with respect to current Good Manufacturing Practice and to the relevant DIN EN ISO 9001 standards, as applicable, and thus fulfils the corresponding requirements of the European Union and of National Drug
Laws. 
 This agreement will also govern as a basis for Gerresheimer and NITEC (for the Duma Multi Grip cap 003424-3000) to make necessary
investments, ensuring NITEC appropriate product availability of products covered by this agreement. 
  

	2.	Products covered by this Agreement 

 The
agreement will reflect the total product portfolio as listed below: 
  

			
	 Product — Gerresheimer article no.
	 	
	
034040-3000 Duma MG 40 ml
	 	
	
034075-3000 Duma MG 75 ml
	 	
	
003424-3000 Duma Multi Grip Cap
	 	
	
045256-4000 Duma Twist-off 250 ml
	 	
	
03827D-3000 Duma Twist Cap TE
	 	

 The estimated annual quantities are listed in Schedule 2. 

  

					
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	3.	Investment Requirements and Nitec Contribution 

 NITEC and Gerresheimer agree to the following investments by Gerresheimer, enabling a commercialisation of the project: 
 Duma Multi Grip closure system 34 mm (003424-3000). 
 Investment in an Injection Mould (IM)
customized to NITEC requirements based upon the Gerresheimer developed cap will be made with a capacity in compliance with the estimated yearly quantities (Schedule 2). 
 The first Mould has a yearly capacity of approx. [...***...] units annually with a maximum weekly capacity of [...***...] units and will be initiated after written consent of Nitec
but not before December 2007. 
 The investment in a second Mould with a yearly capacity of [...***...] units with a weekly maximum
capacity of [...***...] will be initiated after having consent of both parties depending on the annual forecast. 
 Gerresheimer will in
this way secure the capacity including back up for the future and hereby undertakes to have such capacity available to serve Nitec’s requirements of product as forecasted in accordance with this Agreement. 

NITEC will have an exclusivity of the aforementioned Duma Multi Grip Closure mould covering the initial [...***...] calendar years following the
approval of LODOTRA in the first country in the EU or US. Besides this Gerresheimer will grant NITEC for the same [...***...] years the same exclusivity for any corticosteroid and rheumatoid product (excluding Paracetamol). In case the yearly
purchased quantities in the [...***...] or in any subsequent calendar year during the term of this Agreement are [...***...] lower than forecasted in the [...***...] and [...***...] calendar year after launch Gerresheimer
shall — after serving a respective written warning to Nitec and allowing NITEC to place one more order of product, which shall then be taken into account when determining annual purchased quantities – have the right to supply the Duma
Multi Grip closures to other customers, provided that NITEC has been reimbursed by Gerresheimer on a pro rata temporis basis for that portion of the Nitec contribution to the moulds which is attributable to that part of the initial five year term
which has not yet expired at the time of execution of such supplies to other customers by Gerresheimer. 
 Gerresheimer has and will keep full
ownership of the moulds. The direct costs of mould no 1 will be approx. [...***...] of which NITEC will pay [...***...] (the “Nitec Contribution”), e.g. approx. [...***...] of direct mould costs of mould No 1 of
the Vendor/ mould maker including moulds, tests, machine parts, etc. to cover for the above mentioned exclusivity rights. Further, the prices per unit as stated in schedule 1 will be reduced in accordance with the agreed purchase volumes.

 Mould costs shall be settled with an initial payment of [...***...] upon submission of order for the first mould to Vendor/ mould maker
(earliest in December 2007), and a final payment of [...***...] when the first mould has been delivered and approved by NITEC. [...***...] were already paid by NITEC. 
 The companies agree that after the [...***...] years exclusivity Nitec orders will be prioritized against others in using the existing first mould. 

The companies agree that a second mould will be 100 % financed by Gerresheimer. 

  

					
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 Time schedule for the investments.

 The first deliveries of the Duma Multi Grip closure system 34 mm (003424-3000) can be made approx. [...***...]
 months after the submission of the order for the first mould. A separate time schedule will be made by Gerresheimer. 
  

	4.	Prices 

 NITEC and Gerresheimer agree on
the prices as of Schedule 1. All prices are in Euro currency (EUR). 
 These prices are per 1.000 units, DDP (Incoterms 2000), Catalent Pharma
Solutions, Steinbeissstr 2, 73614 Schorndorf, Germany. 
 The quoted prices as per schedule 1 are based on a raw material price of
[...***...], per kg. The prices can be subject to adjustments that are related to a possible change of +/- [...***...] in the price of approved Pharmaceutical raw material according to the specifications, independent of the quantities.

 Prices reflecting the development of the documented raw material prices on approved Pharma raw material according to the Gerresheimer product
specifications are negotiated annually by the end of 3rd quarter in each calendar year. 
  

	5.	Warranty/ Change Control 

 Gerresheimer
warrants that the “Products” are manufactured in compliance with the relevant pharmaceutical regulations and legal provisions and in accordance with specifications agreed upon in writing (see Schedule 3) and that they will be free from any
defects in material or workmanship. 
 Gerresheimer states that each carton is signed and labelled in the right way in accordance with
specifications (see Schedule 3). 
 Gerresheimer will do its utmost not to change production process, production technology, composition of
material used and examination methods during the term of this Agreement. However if such changes occur it will be described in detail with all necessary documentation. Gerresheimer is obligated to inform NITEC in advance about any such change in
writing giving positive results of tests of the “Product” according to product specification. In case of product with specification no 003424-3000 such a change requires the written consent of NITEC prior to this change. 

 

	6.	Responsibility / Obligations for Order and Supply 

 Gerresheimer Is responsible for: 
  

	 	•	 	 holding and maintaining an appropriate manufacturing licence for the manufacture and control of the “Products” 

  

					
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	 	•	 	 informing NITEC without any delay of any restrictions to the manufacturing licence for the ‘Products”. 

 

	 	•	 	 complying with the relevant pharmaceutical regulations and GMP requirements valid in the European Union and in the US and with relevant legal
provisions for the manufacture and control of the “Products”. 

  

	 	•	 	 using of raw material only from accepted and approved vendors for the manufacture of “Product” according to the current US-Drug Master File
(DMF) and other relevant legislations. Any change of raw material quality or a change of the vendor of raw material shall need written approval by NITEC. 

 

	 	•	 	 delivery of originally packed and labelled products to NITEC’s partner for packaging which will initially and until further notice be Catalent
Pharma Solutions, Steinbeissstr 2, 73614 Schorndorf, Germany (CH). 

  

	 	•	 	 periodical transfer of results for microbiological examination of Gerresheimer’s production facilities upon request. 

 

	 	•	 	 provision of audit reports of any authority and self-inspection reports which might have an impact on the quality and supply of “Products” to
NITEC or its partners 

  

	 	•	 	 quality of products in accordance with specifications (schedule 3) and delimitation of pharmaceutical responsibilities (schedule 5).

  

	 	•	 	 transfer of new specifications, including update of relevant change control requirements according to schedule 5. 

 

	 	•	 	 punctuality of deliveries. Delivery 2 (two) working days before and 1 (one) working days after the time agreed upon is considered timely delivery.

  

	 	•	 	 Deliveries within
[...***...]
 days after receiving any firm orders. Insofar and to the extent quarterly forecasts provided by Nitec are of binding character (cf. lit. b, 2nd dash of this section 6), such forecasts are converted to fixed orders upon receipt by Gerresheimer. The parties will
negotiate in good faith to reduce the [...***...] days lead time for the caps and bottles after the first calendar year after launch of LODOTRA. 

 

	 	•	 	 delivery of Gerresheimer’s Certificate of analysis (COA) for each consignment stating the kind of material used, batch number, date of
Manufacture, etc. The Certificate will be dated and signed by authorised personnel of the Quality Unit and will show the name, address and phone number of the original manufacturer. 

 

	 	•	 	 Provision of a security stock which will be agreed annually in respect of the required quantities and development in purchase

  

	 	•	 	 not to undertake any measures or initiate any processes which could have a negative impact on the “Products” manufactured for NITEC.

  

	 	•	 	 In the event that Gerresheimer becomes aware of circumstances (including Force Majeure circumstances) that may cause a delay in the delivery of or any
non-conformance of the Product, Gerresheimer shall notify NITEC 

  

					
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	 	immediately. Gerresheimer shall use its best efforts to avoid any delay in delivery and, if such delay cannot be avoided, shall afford to NITEC its full co-operation to minimize the
effects of delay for NITEC. 

 NITEC is responsible for: 

 

	 	•	 	 nomination of a partner for the manufacturing (packaging) of LODOTRA to which Gerresheimer will deliver the Products. This company will be in a first
step Catalent Pharma Solutions, Steinbeisstr 2, 73614 Schorndorf, Germany (Catalent Pharma Solutions). Any change to this will be made in writing by NITEC to Gerresheimer. 

 

	 	•	 	 Provision of quarterly rolling forecasts reflecting Nitec’s demand of products for the upcoming 18 months, which forecast in each case shall be
binding for the next [...***...] months 

  

	 	•	 	 payment according to terms stated in the Agreement 

  

	 	•	 	 guarantee purchase of quantities set forth in the agreement and in accordance with schedule 1 and the rolling forecast to the extent converted into
firm orders 

  

	 	•	 	 informing Gerresheimer in writing if NITEC wishes for the launch in other countries than the EU or the US special provisions or guidelines to be
followed that are not yet generally known or recognized by EU or US GMP requirements. Both parties shall agree how to proceed. 

  

	 	•	 	 auditing Gerresheimer’s facilities, documentation and quality systems 

 

	 	•	 	 On behalf of NITEC Catalent Pharma Solutions is until further notice responsible for firm orders, which have to be furnished in writing, by telefax or
e-mail and shall be placed by [...***...] days prior to the date when Catalent Pharma Solutions wishes to take delivery, and in accordance with schedule 2. Orders are reflecting NITECs quarterly rolling forecast 

 

	 	•	 	 Nitec may at any time upon written notice to Gerresheimer replace the party responsible for the firm orders. 

 

	 	•	 	 The agreed delimitation of pharmaceutical responsibilities between NITEC and Gerresheimer is given in detail in Schedule 5 of this agreement.

  

	 	•	 	 NITEC and Gerresheimer designate competent contacts for technical matters. The persons and their function are named in Schedule 6 of this agreement.

  

	 	•	 	 The provisions of this agreement apply to all orders for the “Products” that are issued after this agreement is signed and before its
termination is effected. They also apply to orders issued by NITEC to Gerresheimer that have not yet been completed at the time of effective termination of this agreement. 

  

					
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	7.	Site Inspections / Auditing 

 NITEC, its partners or Regulatory Authorities have the right to conduct or to have conducted periodical inspections / audits of production rooms, warehouses, records of QC samples and analytical labs and
records. 
  

	8.	Product Inspections and Complaints 

 NITEC or its partners will inform Gerresheimer immediately of any complaints which are related to the “Products” and will liaise with Gerresheimer in investigating the possible causes and agree
on remedial actions. 
 In case of not proper quality of “Products” (= products not complying to the Specifications
according to Schedule 3, hereinafter: “defective products”) Gerresheimer and NITEC will follow the Gerresheimer complaint procedure described in the respective product specification (schedule 3). In case of improper quality Gerresheimer at
its own discretion shall, in addition to the other remedies provided for in this Agreement (i) replace the “Products” at its own expense promptly but in no invent later than 45 days or (ii) refund such portion of the sales price
as is equitable. In the first case Gerresheimer shall be entitled to require NITEC to dispose of defective products at Gerresheimer’s expense according to the applicable law. 

Irrespective of the foregoing, NITEC or its partners will inspect each shipment of Product for obvious defects and
completeness within [...***...] days after receipt of each delivery and NITEC shall notify or shall cause its partners to notify Gerresheimer of any defects or shortages it has discovered. § 377 HGB (German
Commercial Code) shall not apply. 
 In the event of hidden defects not readily ascertainable upon inspection the party
that first becomes aware of the defect shall notify the other party of any such defect immediately, but in no event later than within [...***...] days, after they have been discovered. 

If there is a dispute whether a Product delivered is defective or whether a Product’s defect has been caused by Nitec or
Nitec’s partners after receipt, a sample of the rejected Product and a sample retained by Gerresheimer shall be exchanged between the parties for inspection. If the parties fail to come to a mutually satisfying conclusion within a period of
[...***...] weeks following the exchange of the samples, both samples shall be submitted to an expert acceptable to both parties as agreed case by case (the “Expert”). The Expert shall determine whether the rejected Product is
defective or not and therefore, to which party such defect is to be attributed, and its determination, in the absence of manifest error, shall be final and binding upon the parties. The costs charged by the Expert shall be borne by the party that
has been found to be wrong by the determination. 
 NITEC or its partner have the right to refuse shipment from
Gerresheimer’s facility if “Products” can be demonstrated to be non-compliant according to the aforementioned provisions. 

  

					
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 Gerresheimer’s obligations
under this section 8 are only valid according to the following provisions: 
 In no case shall a claim
against Gerresheimer of any kind (i) in the event the claim is covered by an insurance, be greater in amount than the respective payment made under Gerresheimer’s insurance plus Gerresheimer’s applying deductibles; and (ii) in
any other case be greater in amount than, for each claim, the value [...***...] of the respective delivery of defective products, and for all claims made during one calendar year, be greater in amount than
[...***...]. This limitation of liability shall not apply (i) in the case of Gerresheimer’s wilful act or gross negligence or (ii) in the event and to the extent that peremptory provisions of the applicable law do not permit
this limitation of liability between Gerresheimer and Nitec. Furthermore, Gerresheimer’s liability for defective products (to the extent that such defect is caused by the actions -including their omission-described hereafter in this sentence)
is subject to Nitec having adhered to all procedure’s and instructions applicable to the conditions of use of the products and any damage caused by fair wear and tear or by misuse occurring after delivery tor Catalent Pharma Solutions (or its
successor in case of a change of the partner of Nitec according to sect. 6 lit.b, 1st dash) or Nitec is expressly excluded. 
 Gerresheimer’s obligations under this section 8 are Gerresheimer’s only obligations under this Agreement with regard to damage-payments for defective products, and Gerresheimer shall in this
regard not be liable any way whatsoever beyond this section 8. 
  

	9.	Agreement Term 

 The
Agreement is valid for a period of exclusivity as defined under section 3 for five (5) calendar years after launch of LODOTRA in the first country in the EU or US (the “initial term”) with possibility of its annual prolongation in
writing. 
  

	10.	Changes in the Agreement 

All changes of the terms set forth in this agreement may only be made by mutual agreement and must be in writing, otherwise would not be
binding. Any waiver of this form requirement shall also have to be in writing in order to become effective. 
  

	11.	Payment 

 All payments
shall be made by NITEC in EUR [...***...] days net following the date of the relevant invoice. 

  

					
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	12.	Confidentiality 

 Both
parties undertake to maintain strict confidentiality, which shall also apply after this agreement has ended. Neither party is entitled to use the knowledge of the other disclosed to it under this agreement, after the end of the agreement or without
the consent of the other party. Excluded are disclosures of information necessary for Authorities. 
  

	13.	Choice of Law 

 This
Agreement shall be exclusively construed in accordance with the laws of Germany without regard to its conflict of law principles or the Vienna Convention on the International Sale of Goods (CISG). The courts of Mannheim shall have exclusive
jurisdiction in any matter arising under or in connection with this Agreement. 
  

	14.	Final Provisions 

 If
changes in the market lead to a situation, which is not reasonable for either party, both parties will endeavour amicably to find a solution acceptable to both of them. The same applies if disputes arise from the performance of the Agreement.

 Delay in or failure to carry out the obligations imposed on any party under this Agreement shall not be
deemed a breach of this Agreement if such delay or failure results from fire, explosion, labour dispute, natural disaster, war, legislative or governmental acts, or any other cause beyond the control of the affected party (collectively
“Force Majeure”). Lack or failure of the affected party’s sub-contractor shall not constitute Force Majeure unless caused by circumstances which represent Force Majeure themselves. In the event delay or failure due to Force
Majeure continues for a period exceeding [...***...] months, either party may terminate this Agreement effective immediately. 
 If individual provisions of this Agreement are invalid or become invalid, the parties hereby agree that this shall not affect the validity of the remainder. The parties undertake to replace the invalid
provisions by others with the same economical effect as far as legally possible. 
 This Agreement including Appendices
constitutes the entire agreement between the parties concerning the subject matter. 
 Gerresheimer acknowledges that partners
or affiliated companies of NITEC might be interested in the future to become a party of this Agreement. However, Gerresheimer reserves its right to refuse its agreement to any respective amendment -which would have to be executed in writing- to this
Agreement whereby partners or affiliated companies of NITEC would, at NITEC’s request, become a party to this Agreement. 

  

					
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 This Agreement has been prepared in 4 (four)
original copies in English and each party hereto acknowledges to have received two original of this Agreement. 
  

					
	     Date: ___________________________________________	 		 	     Date: __________________/_______________________
			
	     Gerresheimer Vaerloese A/S	 		 	     Nitec Pharma AG
	/s/ Niels Düring Division President	 		 	/s/ Jochen Mattis    /s/ Dr. Achim Schaffler
		 		 	     Managing director E VP R&D/ Tech operations

 List of Schedules 
  

			
	 Schedule 1:
	 	Prices
		
	 Schedule 2:
	 	Order Quantities, Delivery and estimated Quantities in the Contract Period
		
	 Schedule 3:
	 	Product Specifications including complaint procedure
		
	 Schedule 4:
	 	Delimitation of Pharmaceutical Responsibilities
		
	 Schedule 5:
	 	Contacts and Responsible Persons

  

					
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 Schedule 1: Prices 

The initial prices are based on the forecast volumes for the initial three years as per Schedule 1: 

 

									
	 Price per 1.000 units for X
units p.a.
	  	   0-1,5 mill.  
	  	1,5-3 mill.	  	3-6 mill.	  	>6 mill.
	 - 034040-3000
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	 - 034075-3000
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	 - 003424-3000
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]

 Schedule 2:
Order Quantities and Delivery 
 Order quantities and delivery sizes are agreed to be optimised fitting to full load trucks, or whatever
quantities optimising the transport cost covered by Gerresheimer. 
 Estimated amounts for EU market 

 

													
	 Product no
	  	 2008
	  	 2009
	  	 2010
	  	 2011
	  	 2012
	  	 2013

	 034040-3000 Duma MG 40 ml
	  		  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	
	 034075-3000 Duma MG 75 ml
	  		  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	
	 Total containers
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]
	 03424-3000 Duma Multi Grip 34 mm
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	
	 Total caps
	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]	  	[...***...]

 The above mentioned
quantities are only estimated forecast (5-year quantities for the main products, e.g. 40 ml, 75 ml, Multi-Grip Cap 3424). 

  

					
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 Schedule 3; Product Specifications
including complaint procedure 
  

					
	Product	  	product specification	  	
	Duma MG 40 ml	  	034040-3000	  	
	Duma MG 75 ml	  	034075-3000	  	
	Duma Multi Grip 3424	  	003424-3000	  	
	Duma Twist-Off 250 ml    	  	045256-4000	  	
	Duma Twist Cap TE	  	03827D-3000	  	

 “Product specification & Certificates” and drawings/pictures are attached 

Pallet specification in accordance with Nitec Pharma and partners requirement – heights of pallets, etc to be agreed upon. 

  

					
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 Schedule 4: 

Delimitation of Pharmaceutical Responsibilities 
 Products: see Section 2 
  

					
	 Activities
	  	 Responsibilities

	  	 NITEC/
partner
	  	 Gerres-
heimer

	
[...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]

  

					
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	 Activities
	  	 Responsibilities

	  	 NITEC/
partner
	  	 Gerres-
heimer

	 [...***...]
	  	 [...***...]
	  	 [...***...]

	 [...***...]
	  	 [...***...]
	  	 [...***...]

	 [...***...]
	  	 [...***...]
	  	 [...***...]

	 [...***...]
	  	 [...***...]
	  	 [...***...]

	 [...***...]
	  	 [...***...]
	  	
	 [...***...]
	  	 [...***...]
	  	
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
			
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  		  	
	 [...***...]
	  	[...***...]	  	[...***...]
	 [...***...]
	  	[...***...]	  	[...***...]

  

					
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 Schedule 5 

Contacts and Responsible Persons 

Products: see Section 2 
 NITEC:

  

									
	     Function    
	 	
      Name      
	 	
      Phone      
	 	
        Fax        
	 	
      e-mail      

	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]

 Gerresheimer:

  

									
	     Function    
	 	
      Name      
	 	
      Phone      
	 	
        Fax        
	 	
      e-mail      

	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]
	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]	 	[...***...]

  

					
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 Appendix 7 – Services 

(By Catalent) 
  

	 	•	 	 Packaging 

  

	 	•	 	 Quality Assurance 

  

	 	•	 	 Product Release for shipment 

 [Catalent shall invoice the annual PQR separately] 

  

					
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 Appendix 8 – Costs of LODOTRA 

(by NITEC) 
  

			
	 Total (Nitec) costs per 1000 bulk tablets (5 mg Lodotra)
	  	[...***...]
	 Total (Nitec) costs per 1000 bulk tablets (2 mg Lodotra)
	  	[...***...]
	 Total (Nitec) costs per 1000 bulk tablets (5 mg Lodotra)
	  	[...***...]

  

					
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