Document:

EX-10.20

 EXHIBIT 10.20 

Execution Version 

KEMPHARM, INC. 

EMPLOYMENT AGREEMENT 

CHRISTAL MICKLE 

DATED MAY 30, 2014 

 KEMPHARM, INC. 

EMPLOYMENT AGREEMENT 

This EMPLOYMENT AGREEMENT (“Agreement”) is made and entered into effective as of the 30th day
of May 2014, by and between KEMPHARM, INC., an Iowa corporation (the “Company”) and CHRISTAL MICKLE (“Executive”) (each being a
“Party” hereto and together constituting the “Parties”). 
 WHEREAS, Executive is currently
employed by Company as its Vice President of Operations and Product Development and Company desires to continue to employ Executive in such capacity under the terms and conditions set forth below. 

NOW, THEREFORE, in consideration of the mutual promises and covenants contained herein, and for other good and
valuable consideration, the receipt, adequacy and sufficiency of which is hereby acknowledged, the Parties hereto agree as follows: 
 1.
EMPLOYMENT. 
 A. Employment. Company hereby continues to employ Executive and Executive hereby
accepts such continued employment with Company as Vice President of Operations and Product Development, or in such other capacities as Company shall reasonably determine from time to time, upon the terms and conditions set forth in this Agreement.

 B. Effective Date and Term. Company’s continued employment of Executive under this Agreement shall commence
effective as of May 30, 2014 (the “Effective Date”), and continue until the Date of Termination (defined in Section 4(A)) (hereinafter such period of time from the commencement until termination of employment shall be
referred to as the “Employment Term”). 
 C. Duties of Executive. During the Employment Term, all of
the following shall apply: Executive shall carry out, perform and comply with such reasonable and lawful orders, directions, and written rules and policies (including those rules and policies memorialized in meeting minutes) as are assigned or set
by Company’s Chief Executive Officer (the “CEO”) from time to time. Executive shall report to, receive directions from and be reviewed by the CEO. Executive’s duties shall include the duties and responsibilities commonly
associated with a Vice President of Operations and Product Development of a company similar to Company. Subject to the limitations of Section 4(E)(3)(iv), the CEO retains the right to modify Executive’s job title and responsibilities
pursuant to the legitimate business needs of Company. 
 D. Duty of Loyalty. During the Employment Term, Executive
shall not, without the prior written consent of the CEO, accept other employment or render or perform other services for compensation. Executive shall devote Executive’s full business time and attention and Executive’s best efforts to the
faithful performance of Executive’s duties as an executive officer and employee of Company. Executive’s expenditure of reasonable amounts of time for teaching, personal business, or on behalf of charitable or professional organizations
shall not be deemed a breach of this Agreement, provided such activities do not materially interfere with the performance of Executive’s duties and responsibilities hereunder. 

E. Place of Performance. Executive’s principal place of employment during the Employment Term will be
Company’s headquarters in Coralville, Iowa; provided that, from time to time, Executive will perform her duties from Executive’s personal residence or a Company worksite in the Orlando, Florida metropolitan area. Notwithstanding the
foregoing, Executive understands and agrees that Executive’s presence may be required at Company headquarters or other Company worksite, or Executive may be required to travel for business, in each case, in accordance with Executive’s
duties and responsibilities under this Agreement, as business needs require or may change over time and as reasonably requested by the CEO. 

  
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 2. COMPENSATION AND BENEFITS.
In consideration of the services to be rendered by Executive pursuant to this Agreement, as well as Executive’s covenants set forth in this Agreement, Company shall pay to Executive the following compensation, which shall be the entire and
exclusive compensation for all of Executive’s services rendered and other obligations taken on Company’s behalf: 

A. Annual Base Salary. During the Employment Term, Company shall pay to Executive an annualized base salary of $141,795
(the “Base Salary”), provided that the Base Salary will be increased automatically to $190,000 upon the successful closing of the debt financing between Company and affiliates of Deerfield Management Company, L.P., which is expected
to be in an amount of up to $60,000,000, which financing is expected to close on or around May 30, 2014 (the “Financing”). For calendar years in which Executive is employed for less than the full year, the Base Salary shall be
prorated and accrue on a per diem basis for only those days on which Executive was employed during the Employment Term. The Base Salary will be paid by Company in equal installments according to Company’s customary payroll practices, but in any
event not less frequently than monthly, and shall be subject to all mandatory and voluntary payroll deductions. Executive’s Base Salary shall be reviewed periodically by the Company’s Board of Directors (“Board of
Directors”) or the Compensation Committee of the Board of Directors (the “Compensation Committee”) if so designated and may be appropriately increased from time to time in the sole discretion of Board of Directors or the
Compensation Committee, as applicable, and may only be decreased proportionately with any across-the-board decrease applicable to all senior executives of Company. 

B. Incentive Compensation. During the Employment Term, Executive shall be entitled to participate in all short-term and
long-term incentive programs established by Company, at such levels as the Board of Directors or Compensation Committee determines. Executive’s annual short-term incentive opportunity target shall be no less than 25% of the Base Salary, as such
percentage may be increased from time to time (the “Target Annual Bonus”). The actual amount of such annual incentive compensation shall be determined in accordance with the applicable plans based on achievement of individual and
Company performance objectives established in advance by the Board of Directors or the Compensation Committee, taking into account input from the CEO, and such actual annual short term incentive compensation amount may be more or less than the
target amount. No minimum incentive is guaranteed. 
 C. Retirement, Welfare and Other Benefit Plans and Programs.
During the Employment Term, Executive shall be entitled to participate in the employee retirement and welfare benefit plans and programs made available to Company’s other senior level executives as a group, as such retirement and welfare plans
may be in effect from time to time and subject to the eligibility requirements of such plans, including but not limited to, life, health and disability plans, and a 401(k) retirement plan and similar or other plans. During the Employment Term,
Executive shall be eligible for vacation, sick leave and holidays in accordance with Company’s vacation, sick and holiday and other pay for time not worked policies. Nothing in this Agreement or otherwise shall prevent Company from amending or
terminating after the Effective Date any retirement, welfare or other employee benefit plans, programs, policies or perquisites from time to time as Company deems appropriate, and Executive’s participation in any such plan, program, policy and
perquisite shall be subject to the terms, provisions, rules and regulations thereof. 
 D. Reimbursement of Expenses.
During the Employment Term, Company shall reimburse Executive for all reasonable and necessary business expenses that Executive incurs while performing Executive’s duties under this Agreement in accordance with Company’s general policies
of expense reimbursement in effect from time to time. 

  
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 3. COMPANY POLICIES AND
PROCEDURES. Executive agrees to observe and comply with the reasonable and lawful policies and procedures of Company as adopted by the Board of Directors in writing or reflected in the formal minutes of the Board of
Directors or committee thereof, respecting performance of Executive’s duties and to carry out and to perform the reasonable and lawful orders and directions stated by Company to Executive, from time to time, either orally or in writing.
Executive agrees that Executive will be subject to any compensation clawback, recoupment and anti-hedging policies that may be applicable to Executive as an executive of Company, as in effect from time to time and as approved by the Board of
Directors or a duly authorized committee thereof. 
 4. TERMINATION. 

A. Notice of Termination and Date of Termination. Each Party must give written notice to the other of the intent to
terminate this Agreement and Executive’s employment hereunder (“Notice of Termination”). The Notice of Termination must specify a date of termination of employment, which shall incorporate any period of notice required by this
Section 4 (“Date of Termination”). 
 B. Executive’s Death or Total Disability.
Executive’s employment under this Agreement shall terminate upon the date of Executive’s death. Additionally, if, during the Employment Term, Executive suffers a Total Disability (as defined in Section 4(E)(3)(iii), then Company may
terminate Executive’s employment under this Agreement by giving Executive a Notice of Termination specifying the Date of Termination. Upon such termination due to death or Total Disability, Company shall pay to Executive or Executive’s
estate (i) any Base Salary that has fully accrued but not been paid as of the effective date of such termination, as well as any vested and accrued employment benefits subject to the terms of any applicable employment benefit arrangements and
applicable law (“Accrued Benefits”) and (ii) a prorated bonus for the year in which Executive’s death or Disability occurs, which bonus shall be calculated and paid in the same manner as set forth below in
Section 4(E)(1)(b). All other rights and benefits of Executive and Executive’s dependents hereunder shall terminate upon such termination, except for any right to the continuation of benefits otherwise provided by law. 

C. By Company with Cause. Company may terminate with Cause (as defined in Section 4(E)(3)(i)) Executive’s
employment hereunder at any time. In order to terminate Executive’s employment hereunder with Cause, Company must give Notice of Termination to Executive specifying the Cause and the Date of Termination, which may be the same date as the date
of the Notice of Termination. Upon termination with Cause, Company shall pay to Executive all Accrued Benefits. All other rights and benefits of Executive hereunder shall terminate upon such termination, except for any right to the continuation of
benefits otherwise provided by law. 
 D. By Executive without Good Reason or by Mutual Agreement. Executive may
terminate Executive’s employment without Good Reason (as defined in Section 4(E)(3)(iv) at any time by giving Company Notice of Termination at least 30 days prior to the Date of Termination designated by Executive. In addition, this
Agreement may be terminated at any time by written mutual agreement of the Parties with or without notice. Upon termination of Executive’s employment by Executive without Good Reason or termination by mutual agreement of the parties, Company
shall pay to Executive all Accrued Benefits. All other rights and benefits of Executive hereunder shall terminate upon such termination, except for any right to the continuation of benefits otherwise provided by law. 

  
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 E. Without Cause by Company or For Good Reason by Executive. Company may
terminate Executive’s employment at any time without Cause (as defined in Section 4(E)(3)(ii)) by giving Executive a Notice of Termination at least one day prior to the Date of Termination, and Executive may terminate
Executive’s employment for Good Reason by giving Company a Notice of Termination in accordance with Section 4(E)(3)(iv) below. Upon termination of Executive’s employment without Cause by Company or for Good Reason by Executive,
Company will pay Executive (i) all Accrued Benefits, (ii) the severance compensation payable set forth below in this Section 4(E), if Executive executes and does not revoke a Release (as defined in Section 4(E)(3)(v). All other
rights and benefits of Executive hereunder shall terminate upon such termination, except for any right to the continuation of benefits otherwise provided by law. 

(1) In the event that Company terminates Executive’s employment without Cause or Executive terminates Executive’s
employment for Good Reason, and Executive executes and does not revoke a Release, then Company shall pay to Executive as severance compensation, the following: 

(a) Executive’s Base Salary (at the rate payable at the time of such termination) for a period of 12 months following the
Date of Termination. Such severance compensation shall be paid by Company in equal installments according to Company’s customary payroll practices, with the first payment made on the first regularly scheduled pay day immediately following the
60th day following the Date of Termination; provided, however, that if such termination of employment occurs within 60 days before, upon or within one year following a Sale (as defined in Section 4(E)(3)(vi)), then Company shall pay such amount
in a lump sum on the first regularly scheduled pay day immediately following the 60th day following the Date of Termination, but (i) the amount will only be paid in a lump sum if the Sale constitutes a “change in control event” as
defined under Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”); and (ii) notwithstanding the preceding clause (i), if the Sale is not a “change in control event” as defined under
Section 409A of the Code and penalty taxes may result under Section 409A of the Code if such severance compensation is paid in a lump sum, then the severance compensation will be paid in equal installments according to Company’s
customary payroll practices, with the first payment made on the first regularly scheduled pay day immediately following the 60th day following the Date of Termination. 

(b) To the extent Executive has an annual incentive compensation award for the year of termination in which the Date of
Termination occurs, Executive shall receive a pro rata Target Annual Bonus award payment for the year in which the Date of Termination occurs (measured at the target level, identified “goal” target or other similar target, without taking
into account any incentive override for above goal performance, or any project-specific or other non-standard incentives), which shall be paid on the first regularly scheduled pay day immediately following the 60th day following the Date of
Termination. The pro rata amount shall be determined as the Target Annual Bonus in effect for the year in which the Date of Termination occurs, multiplied by a fraction, the numerator of which is the number of days in which Executive was employed by
Company during the year in which the Date of Termination occurs, including the Date of Termination, and the denominator of which is 365. 

(c) During the 12 month period following the Date of Termination, if Executive timely elects continued coverage under
Section 4980B of the Code (“COBRA”), Company will reimburse Executive for the monthly COBRA cost of continued health coverage under the health plans of Company paid by Executive for Executive, and, if applicable,
Executive’s spouse and dependents, less the amount that Executive would be required to contribute for health coverage if Executive were an active employee of Company; provided that such reimbursements shall not continue beyond the first to
occur of (x) the date on which 

  
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Executive fails to pay the COBRA cost of continuation coverage under the health plans of Company and (y) the date on which Executive is eligible for substantially similar coverage from a
subsequent employer. These reimbursements will commence on the first regularly scheduled pay day immediately following the 60th day following the Date of Termination and will be paid on the first regularly scheduled pay day of each month, provided
that Executive demonstrates proof of payment of the applicable premiums prior to the applicable reimbursement payment date. 

(d) The vesting of each outstanding equity award granted to Executive will accelerate so that such awards will be fully vested
as of the Date of Termination. If any equity awards vest based on the attainment of performance goals, the performance goals will be deemed to have met as of the Date of Termination, unless such greater amount of vesting is provided for in the
applicable award agreements. 
 (2) Payment of the severance compensation shall be subject to all mandatory and voluntary
payroll deductions. In the event that Executive materially breaches any of Executive’s post-employment covenants or obligations set forth in this Agreement that the Board of Directors reasonably determines is not cured (to the extent the breach
is curable as determined by the Board of Directors) within 15 days following written notice from Company, then the payment of severance compensation pursuant to this section shall terminate immediately and permanently. During the period that
Executive is paid the foregoing severance compensation, Executive shall not further accrue any other benefits under any benefit plans of which Executive was a participant while employed by Company, except as otherwise required by applicable federal
or state law, by the express terms of this Agreement, or by the express terms of such benefit plans; provided, however, that if Executive becomes entitled to and receives the payments described in Section 4(E)(1) of this Agreement, Executive
hereby waives Executive’s right to receive payments under any severance plan or similar program applicable to employees of Company. 

(3) For purposes of this Agreement: 

(i) Executive’s employment will be deemed to have been terminated by Company “with Cause” if the
termination arises from a determination by the Board of Directors that (a) Executive is convicted of (or pleads guilty or nolo contendere to) a crime constituting a misdemeanor involving dishonesty or moral turpitude or any crime constituting a
felony; (b) Executive neglects, refuses or fails to perform Executive’s material duties hereunder (other than a failure resulting from Executive’s incapacity due to physical or mental illness); (c) Executive commits a material
act of dishonesty or otherwise engages in or is guilty of gross negligence or willful misconduct in the performance of Executive’s duties; or (d) Executive materially breaches the provisions of any written non-competition, non-disclosure
or non-solicitation agreement, or any other agreement in effect with Company, including without limitation the provisions of Sections 7 – 9 of this Agreement or Company’s applicable written code of business conduct and compliance policies;
provided, however, Executive shall have 15 days following Company’s provision of the Notice of Termination specifying a condition under clause (b), (c) or (d) constituting Cause to cure such condition (to the extent the condition is
curable as reasonably determined by the Board of Directors), before which time a termination with Cause cannot be effective unless such condition remains uncured as reasonably determined by the Board of Directors. 

(ii) Executive’s employment shall be deemed to have been terminated by Company “without Cause” if such
termination is not with “Cause,” and such termination is not the result of Executive’s death or Executive suffering a Total Disability. 

  
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 (iii) Executive shall be deemed to have suffered a “Total
Disability” if (a) Executive is granted long-term disability benefits under Company’s long-term disability plan or (b) Executive becomes physically or mentally disabled so that Executive is unable to perform the essential
functions of Executive’s job, with or without reasonable accommodation in accordance with the Americans with Disabilities Act and its amendments, for a period of 180 consecutive days. 

(iv) Executive shall be deemed to have terminated Executive’s employment for “Good Reason” if Executive
terminates Executive’s employment on account of the occurrence of one or more of the following without Executive’s consent: 
 (a)
A material diminution by Company of Executive’s authority, duties or responsibilities, other than a diminution of authority, duties or responsibilities during a 15-day cure period following Company’s notice to Executive of a termination
with Cause, temporarily while Executive is physically or mentally incapacitated, or otherwise as required by applicable law; 
 (b) A
material change in the geographic location at which Executive must perform services under this Agreement (which, for purposes of this Agreement, means the requirement that Executive work from a location more than 50 miles from the Coralville, Iowa
or Orlando, Florida or any other location at which Executive principally performs her duties immediately prior to the relocation); 
 (c) A
material diminution in Executive’s Base Salary which is not the result of an across-the-board reduction in base salaries of other senior executives of Company; or 

(d) Any action or inaction that constitutes a material breach by Company of this Agreement, including the failure of Company to pay any
amounts due under Section 2 or the failure of Company to obtain from its successors the express assumption and agreement required under Section 17(A). 

Executive must provide Notice of Termination for Good Reason to Company within 60 days after the event constituting Good Reason. Company shall
have a period of 30 days in which it may correct the act or failure to act that constitutes the grounds for Good Reason as set forth in Executive’s Notice of Termination. If Company does not correct the act or failure to act, then, in order for
the termination to be considered a Good Reason termination, Executive must terminate Executive’s employment for Good Reason by giving Notice of Termination with a Date of Termination designated by Executive which is at least 30 days after the
date on which the Notice of Termination is given but not more than 90 days after the end of the cure period. 
 (v) The term
“Release” shall mean a release of claims approved by Company, which shall be in the form attached hereto as Exhibit B, subject to revision based on advice from Company counsel to comply with changes in applicable law. 

(vi) The term “Sale” means the sale of more than 50% of the equity of Company, a merger of Company with an
entity the equity of which after the merger the stockholders of Company immediately prior to such merger own less than 50%, or the sale of all or substantially all of the assets of Company, in any case to a person or entity not affiliated with
Company. Neither a recapitalization nor change of form of Company shall be 

  
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considered a Sale. Additionally, a “Sale” shall not be deemed to have occurred as a result of a lender exercising any of its remedies in connection with the occurrence or continuation
of an event of default under that certain Facility Agreement, to be dated as of or around May 30, 2014, by and between Company and Deerfield Private Design Fund III, L.P. 

(4) In the event Company terminates Executive’s employment with Cause, Executive voluntarily terminates Executive’s
employment with Company other than for Good Reason, or such employment is terminated by mutual agreement or as the result of Executive’s death or Total Disability, Executive shall not be entitled to payment of any severance compensation under
this Agreement and Executive shall not be entitled to receive severance benefits under any Company severance plan. 
 F.
Cooperation after Notice of Termination. Following any Notice of Termination by either Company or Executive, Executive, if requested by Company, shall reasonably cooperate with Company in all matters relating to the winding up of
Executive’s pending work on behalf of Company and the orderly transfer of any such pending work to other employees of Company as may be reasonably designated by Company following the Notice of Termination. Executive shall not receive any
additional compensation during the Employment Term, other than Executive’s Base Salary, for any services that Executive renders as provided in this Section 4(F). For each day that Executive performs services under this Section 4(F)
after the Employment Term, Executive shall be reimbursed for her reasonable out-of-pocket expenses and, after the final payment by Company of any and all severance compensation due to Executive under Section 4(E), Company shall pay Executive a
per diem cash amount at Executive’s Base Salary rate on the Date of Termination. 
 G. Surrender of Records and
Property. Upon termination of employment, Executive shall promptly turn-over or deliver to Company at Company’s expense all property of Company in Executive’s possession, custody, or control, including without limitation thereto:
records (paper and electronic), files (paper and electronic), documents (paper and electronic), electronic mail (e-mail) on Company accounts, letters, financial information, memorandum, notes, notebooks, contracts, project manuals, specifications,
reports, data, tables, calculations, data, electronic information, and computer disks, in all cases whether or not such property constitutes Confidential Information (as defined below), and all copies thereof; all keys to motor vehicles, offices or
other property of Company; and all computers, cellular phones and other property of Company. If any of the foregoing property of Company is electronically stored on a computer or other storage medium owned by Executive or a friend, family member or
agent of Executive, such information shall be copied onto a computer disk to be delivered to Company together with a written statement of Executive that the information has been deleted from such person’s computer or other storage medium. 

H. Resignation from Boards. If Executive’s employment with Company terminates with Cause, Executive shall
immediately resign from all boards of directors of Company, any affiliates and any other entities for which Executive serves as a representative of Company. If Executive’s employment is terminated for any other reason (other than death),
Executive shall immediately resign from all boards of directors of Company, any affiliates and any other entities for which Executive serves as a representative of Company, if requested by the Board of Directors and consistent with the terms of the
KemPharm, Inc. Voting Agreement dated on around the Effective Date (the “Voting Agreement”). To the extent Executive remains as a member of any boards of directors of Company, any affiliates and other entities following termination
of employment (other than a termination of employment by Company with Cause), Executive shall remain on such boards for the remainder of the then current term and may be re-elected in accordance with the normal election procedures for the applicable
board and consistent with the Voting Agreement.  

  
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 5. SECTION 280G OF THE
CODE. 
 A. Shareholder Approval, etc. At any time when Company is a corporation described in
Section 280G(b)(5)(A)(ii)(I) of the Code, if a nationally recognized United States public accounting firm selected (and paid for) by Company (the “Accountant”) determines that any payment or benefit (including any accelerated
vesting of equity awards) made or provided, or to be made or provided, by Company (or any successor thereto or affiliate thereof) to or for the benefit of Executive, whether pursuant to the terms of this Agreement, any other agreement, plan, program
or arrangement of or with Company (or any successor thereto or affiliate thereof) or otherwise in connection with, or arising out of, a change in ownership or an effective control of Company or of a substantial portion of assets (any such payment or
benefit, a “Parachute Payment”), will be subject to the excise tax imposed by Section 4999 of the Code or any comparable tax imposed by any replacement or successor provision of United States tax law (the “Excise
Tax”), if Executive waives Executive’s right to receive all or a portion of the Parachute Payments unless such Parachute Payments are approved by the shareholders pursuant to Treas. Reg. Section 1.280G-1, Q&A-7, Company shall
in good faith seek to obtain approval of payment of such waived Parachute Payments in accordance with the shareholder approval requirements described in Treas. Reg. Section 1.280G-1, Q&A-7. 

B. Better Off. If, following the date when Company ceases to be corporation described in
Section 280G(b)(5)(A)(ii)(I) of the Code, it is determined by the Accountant that Executive shall become entitled to a Parachute Payment, which Parachute Payment shall be subject to the Excise Tax, then Company shall cause to be determined,
before any amounts of any Parachute Payment is paid to Executive, which of the following two alternative forms of payment would result in Executive, on an after-tax basis, retaining the greater amount of Parachute Payments, notwithstanding that all
or a portion of the Parachute Payments may be subject to the Excise Tax: (a) payment in full of all Parachute Payments or (b) payment of only a part of the Parachute Payments so that Executive receives the largest payment possible without
the imposition of the Excise Tax (a “Reduced Payment”). For purposes of this Section 5(B), the Accountant shall take into account all applicable federal, state and local income and employment taxes and the Excise Tax (all
computed at Executive’s actual marginal tax rate). If a Reduced Payment is made, (i) Executive shall have no rights to any additional payments and/or benefits constituting the Parachute Payments, and (ii) reduction in payments and/or
benefits shall occur in the manner that results in the greatest economic benefit to Executive as determined in Section 5(C). 

C. Method of Determination. One or more determinations (each a “Tax Determination”) as to whether any
of the Parachute Payments will be subject to the Excise Tax shall be made by the Accountant (with all costs related thereto paid by Company). For purposes of determining whether any of the Parachute Payments will be subject to the Excise Tax:
(i) all of the Parachute Payments shall be treated as “parachute payments” (within the meaning of Section 280G of the Code) unless and to the extent that in the written advice of the Accountant, certain Payments should not
constitute parachute payments, and (ii) all “excess parachute payments” (within the meaning of Section 280G of the Code) shall be treated as subject to the Excise Tax unless and only to the extent that the Accountant advises
Company that such excess parachute payments are not subject to the Excise Tax. 
 6. INTELLECTUAL
PROPERTY. 
 A. Work Product. During the Employment Term, Executive will be expected to perform
duties which may lead to and include the discovery, creation, development, or expression of inventions, discoveries, developments, modifications, procedures, ideas, innovations, systems, programs, know-how, literary properties, chemical or
biological data, computer software, improvements, processes, methods, formulas, systems, creative works and techniques (collectively, hereinafter “Work Product”). 

  
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 B. Assignment. Executive hereby assigns and transfers to Company, and
agrees that Company shall be the sole owner of all Work Product conceived, developed or made by Executive (alone or with others), whether during working hours or at any other time, in whole or in part during Executive’s employment with Company
(including prior to, during and after the Employment Term), whether at the request or upon the suggestion of Company or otherwise, which are useful in, or directly or indirectly related to Company’s business or any contemplated business of
Company or which relate to, or are conceived, developed, or made in the course of, Executive’s employment or which are developed or made from, or by reason of knowledge gained from, such employment. 

C. Work for Hire. Executive hereby agrees that all work or other material containing or reflecting any Work Product
shall be deemed a work made for hire under the U.S. Copyright Act. To the extent any such Work Product is determined that it is not a work made for hire, Executive hereby assigns to Company all of Executive’s right, title and interest,
including all rights of copyright, patent, trade secret and other intellectual property rights, in, to and under the Work Product. 

D. Continuing Obligations. Executive agrees to disclose promptly all Work Product conceived or made by Executive (alone
or with others) to which Company is entitled to as provided herein, and agrees not to disclose such Work Product to others except as required by law or as is reasonably necessary or appropriate in connection with the performance of Executive’s
duties as an employee and officer of Company, without the express written consent of Company. Executive further agrees that during the Employment Term and at any time thereafter, Executive will, upon request by Company, provide all assistance
reasonably required to protect, perfect and use the Work Product, including execution of proper assignments to Company of any and all such Work Product to which Company is entitled, execution of all papers and performance all other lawful acts which
Company may deem necessary or advisable for the preparation, prosecution, procurement and maintenance of trademarks, copyrights and or patent applications, and execution of any and all proper documents as shall be required or necessary to vest title
in Company to such Work Product. It is understood that all expenses in connection with such trademarks, copyrights or patents, and all applications related thereto, shall be borne by Company, however Company is under no obligation to protect such
Work Product, except at its own discretion and to such extent as Company shall deem desirable. Executive shall not receive any additional compensation during the Employment Term, other than Executive’s Base Salary, for any services that
Executive renders as herein provided. For each day that Executive performs services under this Section 6(D) after the Employment Term, Executive shall be reimbursed for her reasonable out-of-pocket expenses and, after the final payment by
Company of any and all severance compensation due to Executive under Section 4(E), Company shall pay Executive a per diem cash amount at Executive’s Base Salary rate on the Date of Termination. 

7. CONFIDENTIAL INFORMATION. 

A. Confidential Information. The term “Confidential Information” means all information related to
Company’s business, which exists or is developed at any time while Executive is an employee, officer and/or director of Company (including prior to, during and after the Employment Term), including without limitation: (i) strategic and
development plans, financial information, equity investors, business plans, co-developer identities, business relationships, business records, project records, market reports, information relating to processes and techniques, technology, research,
data, development, trade secrets, know-how, discoveries, ideas, concepts, specifications, diagrams, inventions, technical and statistical data, designs, drawings, models, flow charts, engineering, products, invention disclosures, patent
applications, chemical and molecular structures, synthetic pathways, biological data, safety data, clinical data, developmental data, development route, manufacturing processes, synthetic techniques, analytical data, Work Product, and any and all
other proprietary and sensitive information, disclosed or learned, whether oral, written, graphic or machine-readable, whether or not marked confidential or proprietary, whether or not patentable, whether or not

  
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copyrightable, including the manner and results in which any such Confidential Information may be combined with other information or synthesized or used by Company, which could prove beneficial
in enabling a competitor to compete with Company; or (ii) information that satisfies the definition of a “trade secret” as that term is defined in the Iowa Uniform Trade Secrets Act, IA Code Chpt. 550, as amended from time to time;
provided, however, that information that is in the public domain (other than as a result of a breach by Executive of this Section 7), approved for release by Company, or lawfully obtained from a third party who is not known by Executive (after
Executive’s reasonable inquiry) to be bound by a confidentiality agreement with Company is not Confidential Information. 

B. Acknowledgements. Executive acknowledges and agrees that: (1) Executive’s position with Company is one of
high trust and confidence, (2) the Confidential Information constitutes a valuable, special and unique asset which Company uses to obtain a competitive advantage over its competitors, (3) Executive’s protection of such Confidential
Information against unauthorized use or disclosure is critically important to Company in maintaining its competitive advantage, (4) all Confidential Information is the property of Company, and (5) Executive shall acquire no right, title or
interest in, to or under any such Confidential Information. 
 C. Nondisclosure. Executive promises that Executive
will never (before, during or after the Employment Term): (1) disclose any Confidential Information to any person other than (i) an officer or director of Company; or (ii) any other person who is bound by nondisclosure restrictive
covenants to Company and to whom disclosure of such Confidential Information is reasonably necessary or appropriate in connection with performance by Executive of Executive’s duties as an employee and officer of Company; or (2) use any
Confidential Information except to the extent it is reasonably necessary or appropriate in connection with performance by Executive of Executive’s duties as an employee and officer of Company. Executive promises to take all reasonable
precautions to prevent the inadvertent or accidental disclosure or misuse of any Confidential Information. In the event Executive receives a request to disclose all or any part of the Confidential Information under the terms of a subpoena or order
issued by a court or governmental body, Executive promises, to the extent permissible by law, to (a) notify Company immediately of the existence, terms and circumstances surrounding such request, (b) consult with Company on the
advisability of taking legally available steps to resist or narrow such request, (c) if disclosure is required, furnish only such portion of the Confidential Information as Executive is legally compelled to disclose; and (e) exercise
Executive’s best efforts to obtain an order or other reliable assurance that confidential treatment will be accorded to the disclosed Confidential Information. 

8. NONCOMPETITION. 

A. Restricted Period. As used in this Agreement, the term “Restricted Period” means throughout the
Employment Term and continuing until the end of the 12 month period following the date on which Executive’s employment with Company is terminated for any reason (whether voluntary or involuntary). 

B. Prohibition on Competition. Executive hereby covenants and agrees that, until the expiration of the Restricted
Period, except for any activity identified on Exhibit A, Executive will not serve as an officer, director, employee, independent contractor, consultant or agent of, or have any ownership interest in, any business entity which engages in any
activities anywhere in the world that are materially similar to or competitive with Company’s pharmaceutical prodrug development and Commercialization (as defined below) activities in the fields of (i) opioid products for the treatment of
pain, (ii) stimulant products for the treatment of ADHD, and/or (iii) such other products which Company is actively and demonstrably developing and/or Commercializing at the time Executive’s employment is terminated. If a court of
competent jurisdiction finds this non-competition provision invalid or unenforceable due to unreasonableness in time, geographic scope, or scope of Company’s 

  
 - 10 - 

 
business, then Executive agrees that such court shall interpret and enforce this provision to the maximum extent that such court deems reasonable. For purposes of this Agreement,
“Commercialize” or “Commercialization” means the sales and marketing phase with regard to a specific drug candidate in a specific country or region following the regulatory approval of said drug candidate in the applicable
country or region. 
 C. Exceptions. Executive’s ownership of less than 5% of the stock of a company that is
competitive with the activities of Company as described in Section 8(B) and listed on a national securities exchange shall not be deemed to violate the prohibitions of Section 8(B). Also, Executive shall not be considered to have violated
Section 8(B) with respect to the purchasing entity if there is a Sale and Executive becomes an employee, officer, director or shareholder of the purchasing entity. 

9. NONSOLICITATION OF EMPLOYEES. Until the expiration of the Restricted Period, Executive
shall not, directly or indirectly, either on Executive’s own account or for any other person or entity: (a) employ, solicit, induce, advise, or otherwise convince, interfere with Company’s employment of, or offer employment to, any
employee of Company; (b) employ or otherwise interfere with Company’s engagement with, or offer employment to, any consultant of Company; or (c) induce or attempt to induce any such employee or consultant to breach their employment
agreement or relationship or consulting agreement or relationship with Company; provided, however, that Executive shall not be in breach of this provision if any such employee or consultant, without inducement or solicitation by Executive, applies
for employment at Executive’s subsequent employer in response to a general advertisement soliciting employment. 
 10.
REASONABLENESS OF RESTRICTIONS; REMEDIES. Executive has carefully read and considered the restrictive covenants set forth in Sections 7 – 9 hereof, and
understands Executive’s obligations thereunder, the limitations such obligations will impose upon Executive after termination of Executive’s employment with Company, and that the Restricted Period extends for 12 months after the
termination of Executive’s employment. Executive has had full opportunity to review with Executive’s personal attorney this Agreement, including Sections 7 – 9, before executing the Agreement. Executive agrees that, as a result of
Executive’s position with Company, the length of the Restricted Period and each restriction set forth in Sections 7, 8 and 9 herein are (1) fair and reasonable, (2) reasonably required for the protection of the legitimate business
interests and goodwill established by Company, and (3) not overly broad or unduly burdensome to Executive. Executive acknowledges that Executive’s compliance with Executive’s obligations and restrictive covenants set forth in this
Agreement is necessary to protect the business and goodwill of Company. Executive agrees that Executive’s breach of Executive’s obligations and/or restrictive covenants under this Agreement may irreparably and continually damage Company,
for which money damages may not be adequate. Consequently, Executive agrees that in the event that Executive breaches or threatens to breach any of the covenants or agreements contained herein, Company shall be entitled to: (a) seek injunctive
relief to prevent or halt Executive from breaching this Agreement; and (b) money damages as determined appropriate by a court of competent jurisdiction. Executive hereby agrees that injunctive relief may be granted by a court of competent
jurisdiction without the necessity of Company to post bond, or if required to post bond, Executive agrees that the lowest amount permitted shall be adequate. Nothing in this Agreement shall be construed to prohibit Company from pursuing any other
remedy available or from seeking to enforce any restrictive covenants to a lesser extent than set forth herein. The Parties agree that all remedies shall be cumulative. Each party is responsible for its own costs and expenses, including
attorneys’ fees. 

  
 - 11 - 

 11. NO PRIOR RESTRICTIONS.
Executive hereby represents and warrants to Company that the execution, delivery, and performance by Executive of Executive’s duties under this Agreement do not violate any provision of any agreement or restrictive covenant which Executive has
with any former employer or any other entity. Executive further agrees to honor and inform Company of any and all post-employment obligations Executive has to any former employer or any other entity with which Executive has or had a business
relationship. 
 12. NOTICES. Any notice or communication required or permitted to be given hereunder may be delivered
by hand, deposited with an overnight courier, sent by confirmed email, confirmed facsimile, or mailed by registered or certified mail, return receipt requested, postage prepaid, in the case of Company, addressed to Company’s principal office
marked attention to Company’s president, and in the case of Executive, addressed to Executive’s personal address as appearing in Company’s payroll records, and in each case to such other mail address, e-mail address, or facsimile
number as may hereafter be furnished in writing by either Party to the other Party. Such notice will be deemed to have been given as of the date it is hand delivered, emailed, faxed or three days after deposit in the U.S. mail. 

13. LIKENESS. Executive hereby grants to Company a license to use, without further compensation or approval from
Executive, Executive’s name, image, portrait, voice, likeness and all other rights of publicity, or any derivative or modification thereto that Company may create, in any and all mediums, now known or hereafter developed, provided that such use
is in relation to Company’s business and consistent with professional business standards, and does not disparage or denigrate Executive. Provided, however, if written notice is provided to Company by Executive following termination of
Executive’s employment requesting that Company cease using Executive’s likeness, Company has 30 days to cease using Executive’s likeness in the manner set forth in the notice. 

14. SECTION 409A; SECTION 162(M). 

A. This Agreement is intended to comply with Section 409A of the Code and its corresponding regulations, or an exemption,
and payments may only be made under this Agreement upon an event and in a manner permitted by Section 409A of the Code, to the extent applicable. Severance benefits under the Agreement are intended to be exempt from Section 409A of the
Code under the “short-term deferral” exception, to the maximum extent applicable, and then under the “separation pay” exception, to the maximum extent applicable. Notwithstanding anything in this Agreement to the contrary, if
required by Section 409A of the Code, if Executive is considered a “specified employee” for purposes of Section 409A and if payment of any amounts under this Agreement is required to be delayed for a period of six months after
separation from service pursuant to Section 409A of the Code, payment of such amounts shall be delayed as required by Section 409A of the Code, and the accumulated amounts shall be paid in a lump sum payment within 10 days after the end of
the six month period. If Executive dies during the postponement period prior to the payment of benefits, the amounts withheld on account of Section 409A of the Code shall be paid to the personal representative of Executive’s estate within
60 days after the day of Executive’s death. The Parties agree that this Section 14 shall not be construed in a manner so as to accelerate any payments due under this Agreement. 

B. All payments to be made upon a termination of employment under this Agreement may only be made upon a “separation from
service” under Section 409A of the Code. For purposes of Section 409A of the Code, each payment hereunder shall be treated as a separate payment and the right to a series of installment payments under this Agreement shall be treated
as a right to a series of separate payments. In no event may Executive, directly or indirectly, designate the calendar year of a payment. All reimbursements and in-kind benefits provided under the Agreement shall be made or provided in accordance
with the requirements of Section 409A of the Code. 

  
 - 12 - 

 C. Executive agrees that if the stock of the Company becomes publicly traded,
Executive will make any amendments to the Agreement that the Company deems necessary to allow performance-based compensation to qualify for the “qualified performance-based compensation” exception to Section 162(m) of the Code. 

15. ATTORNEYS’ FEES FOR NEGOTIATION OF THIS
AGREEMENT. Company shall pay for the reasonable attorneys’ fees incurred by Executive in connection with the review, negotiation and documentation of this Agreement, up to a maximum of $3,000 in the aggregate.

 16. INDEMNIFICATION; LIABILITY INSURANCE. Company shall indemnify and
hold Executive harmless to the fullest extent permitted by the laws of Company’s state of organization or incorporation in effect at the time against and in respect of any and all actions, suits, proceedings, claims, demands, judgments, costs,
expenses (including advancement of reasonable attorney’s fees), losses, and damages resulting from Executive’s performance of Executive’s duties and obligations with Company. Executive will be entitled to be covered, both during and,
while potential liability exists, by any insurance policies the Employer may elect to maintain generally for the benefit of officers and directors of the Employer against all costs, charges and expenses incurred in connection with any action, suit
or proceeding to which Executive may be made a party by reason of being an officer or director of Company in the same amount and to the same extent as Company covers its other officers and directors. These obligations shall survive the termination
of Executive’s employment with Company. 
 17. GENERAL PROVISIONS. 

A. Successors and Assigns. The rights and obligations under this Agreement shall survive the termination of
Executive’s services to Company in any capacity and shall inure to the benefit and shall be binding upon Executive’s heirs and personal representatives. Executive’s duties and obligations are personal in nature and Executive may not
assign or delegate any duties under this Agreement without Company’s prior written approval. Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation, reorganization or otherwise) to all or
substantially all of the business or assets of Company, within 15 days of such succession, expressly to assume and agree to perform this Agreement in the same manner and to the same extent as Company would be required to perform if no such
succession had taken place and Executive acknowledges that in such event the obligations of Executive hereunder will continue to apply in favor of the successor. As used in this Agreement, “Company” shall mean Company and any such
successor which assumes and agrees to perform the duties and obligations of Company under this Agreement by operation of law or otherwise. 

B. Survival of Certain Terms. The terms, conditions and covenants set forth in this Agreement which specifically relate
to periods, activities or obligations upon or subsequent to the termination of Executive’s employment, including, without limitation, the restrictive covenants contained in Sections 7 – 9, shall survive the termination of this Agreement
and Company’s employment of Executive hereunder, and the Parties shall remain bound by such terms, conditions and covenants. 

C. Governing Law; Jurisdiction. This Agreement shall be governed by and construed and enforced in accordance with the
procedural and substantive laws of the State of Iowa, without regard to its conflicts of laws provisions. The litigation of any disputes arising out of this Agreement shall take place in the appropriate federal or state court located in Johnson
County, Iowa. The parties, to the extent they can legally do so, hereby consent to service of process, and to be sued in the State of Iowa and consent to the exclusive jurisdiction of the courts of the State of Iowa and the United States District
Court for the Southern District of Iowa, as well as to the jurisdiction of all courts to which an appeal may be taken from such courts, for the purpose of any suit, action or other proceeding arising out of any of their obligations hereunder or with
respect to the transactions contemplated hereby, and 

  
 - 13 - 

 
expressly waive any and all objections they may have to venue in such courts. Notwithstanding the foregoing, should Executive refuse to comply with an order or judgment of such court, then
Company may enforce this Agreement and the order or judgment of such court in any jurisdiction it deems appropriate. 
 D.
Severability, Reform. If any provision of this Agreement is determined to be void, invalid or unenforceable, the remainder shall be unaffected and shall be enforceable as if the void, invalid or unenforceable part was not a provision of the
Agreement. 
 E. Entire Agreement. This Agreement and its attached exhibits, which by this reference are hereby
incorporated into and made a part of this Agreement as if set forth herein verbatim, contain the entire understanding of the parties to this Agreement and supersede and replace all former agreements or understandings, oral or written, between
Company and Executive, including any offer letter sent to Executive, regarding the subject matter hereof. 
 F.
Modification and Waiver. This Agreement may not be amended except by a written instrument signed by both Parties which specifically refers to the particular provision or provisions being amended. No provision of this Agreement may be waived
except in a written instrument that specifically refers to the particular provision or provisions being waived and is signed by the Party against whom the waiver is being asserted. No waiver by any Party of any right, power or privilege hereunder
shall constitute a waiver of any other right, power or privilege hereunder, and no waiver by any party of any breach of a provision hereunder shall constitute a waiver of any other breach of that or any other provision of this Agreement. 

G. Taxes; Withholding. All compensation and benefits payable to Executive under this Agreement shall be subject to all
income and other employment tax withholding and reporting required by federal, state or local law with respect to compensation, benefits and reimbursable expenses paid by a corporation to an employee. Executive shall be responsible for all taxes
applicable to amounts payable under this Agreement. 
 H. Assistance in Litigation. Executive shall reasonably
cooperate with Company in the defense or prosecution of any claims or actions now in existence or that may be brought in the future against or on behalf of Company that relate to events or occurrences that transpired while Executive was employed by
Company. Executive’s cooperation in connection with such claims or actions shall include being available to meet with counsel to prepare for discovery or trial and to act as a witness on behalf of Company at mutually convenient times. Executive
also shall cooperate fully with Company in connection with any investigation or review by any federal, state or local regulatory authority as any such investigation or review relates, to events or occurrences that transpired while Executive was
employed by Company. Notwithstanding anything to the contrary in this Section 17(H), unless otherwise mutually agreed between Executive and Company in writing and, for each day that Executive performs services under this Section 17(H)
Executive shall be reimbursed for her reasonable out-of-pocket expenses and, after the final payment by Company of any and all severance compensation due to Executive under Section 4(E), Company shall pay Executive a per diem cash amount at
Executive’s Base Salary rate on the Date of Termination. 
 I. Beneficiaries; References. Executive shall be
entitled to select (and change to the extent permitted under any applicable law) a beneficiary or beneficiaries to receive any compensation or benefit payable hereunder following Executive’s death, and may change such election, in either case
by giving Company written notice thereof. In the event of Executive’s death or a judicial determination of Executive’s incompetence, reference in this Agreement to Executive shall be deemed, where appropriate, to refer to Executive’s
beneficiary, estate or other legal representative. Any reference to any gender in this Agreement shall include, where appropriate, the other gender. 

  
 - 14 - 

 J. Voluntary Agreement. Each Party to this Agreement has read and fully
understands the terms and provisions hereof, has had an opportunity to review this Agreement with legal counsel, has executed this Agreement based upon such party’s own judgment and advice of counsel, and knowingly, voluntarily and without
duress, agrees to all of the terms set forth in this Agreement. The Parties have participated jointly in the negotiation and drafting of this Agreement. If an ambiguity or question of intent or interpretation arises, this Agreement will be construed
as if drafted jointly by the Parties and no presumption or burden of proof will arise favoring or disfavoring any party because of authorship of any provision of this Agreement. Except as expressly set forth in this Agreement, neither the Parties
nor their affiliates, advisors and/or their attorneys have made any representation or warranty, express or implied, at law or in equity with respect of the subject matter contained herein. Without limiting the generality of the previous sentence,
Company, its affiliates, advisors and/or attorneys have made no representation or warranty to Executive concerning the state or federal tax consequences to Executive regarding the transactions contemplated by this Agreement. 

K. Effect of Headings. Headings to sections and paragraphs of this Agreement are for reference only, and do not form a
part of this Agreement, or effect the interpretation of this Agreement. 
 L. Counterparts. This Agreement may be
executed in counterparts, including by transmission of facsimile or PDF copies of signature pages, each of which shall for all purposes are deemed to be an original and all of which shall constitute on instrument. All signatures of the parties
transmitted by facsimile or PDF shall be deemed to be their original signatures for all purposes. 
 [SIGNATURE PAGE FOLLOWS] 

  
 - 15 - 

 SIGNATURE PAGE 

OF 

EMPLOYMENT AGREEMENT 

IN WITNESS WHEREOF, Company has caused this Agreement to be duly executed and delivered by its
duly authorized officer, and Executive has duly executed and delivered this Agreement, as of the date first written on page 1 of this Agreement. 
  

							
	KEMPHARM, INC. (“COMPANY”):	 		 	CHRISTAL MICKLE:
				
	By:	 	 /s/ Travis C. Mickle
	 		 	 /s/ Christal Mickle

		 	Travis C. Mickle	 		 	
		 	President and Chief Executive Officer	 		 	

  
 - 16 - 

 EXHIBIT A 

LIST OF OUTSIDE BUSINESS ACTIVITIES 

 

	1.	Perform limited business services for Mickle Investments, LLC, which entity is jointly owned by Christal and Travis Mickle. Mickle Investments, LLC, dba Mickle Consulting, LLC, provides consulting services (performed by
Travis Mickle) to Shire Pharmaceuticals LLC, pursuant to that certain consulting agreement between Shire Pharmaceuticals LLC and Travis Mickle dated December 17, 2012. 

  
 - 17 - 

 EXHIBIT B 

RELEASE OF CLAIMS 

Separation of Employment Agreement and General Release 

THIS SEPARATION OF EMPLOYMENT AGREEMENT AND GENERAL RELEASE (the “Agreement”) is made as of this
            day of             ,             , by and between
Christal Mickle (“Executive”) and KemPharm, Inc. (the “Company”). 
 WHEREAS, Executive is employed by
Company as Vice President of Operations and Product Development; 
 WHEREAS, Executive and Company entered into an Employment Agreement,
dated May 30, 2014, (the “Employment Agreement”) which provides for certain benefits in the event that Executive’s employment is terminated on account of a reason set forth in the Employment Agreement; 

WHEREAS, Executive’s employment with Company will terminate effective
            (the “Termination Date”); and 
 WHEREAS, in
connection with the termination of Executive’s employment, the parties have agreed to a separation package and the resolution of any and all disputes between them. 

NOW, THEREFORE, IT IS HEREBY AGREED by and between Executive and Company as follows: 

1. Executive, for and in consideration of the commitments of Company as set forth in paragraph 6 of this Agreement, and intending to be
legally bound, does hereby REMISE, RELEASE AND FOREVER DISCHARGE Company, its stockholders, its present and past affiliates, subsidiaries and parents, their respective officers, directors, investors, employees, and agents, and their respective
predecessors, successors and assigns, heirs, executors, and administrators (collectively, “Releasees”), subject to the exceptions of Section 2 of the Agreement, from all causes of action, suits, debts, claims and demands
whatsoever in law or in equity, which Executive ever had, now has, or hereafter may have, whether known or unknown, or which Executive’s heirs, executors, or administrators may have, by reason of any matter, cause or thing whatsoever, from the
beginning of time to the date of this Agreement, to the extent arising from or relating in any way to Executive’s employment relationship with Company, the terms and conditions of that employment relationship, and/or the termination of that
employment relationship, including, but not limited to, (i) any claims for monetary damages arising under the Age Discrimination in Employment Act (“ADEA”), the Older Workers Benefit Protection Act (“OWBPA”),
Title VII of The Civil Rights Act of 1964, the Americans with Disabilities Act; (ii) any and all claims arising under the Family and Medical Leave Act of 1993, the Employee Retirement Income Security Act of 1974, as amended; (iii) any and
all claims arising under any applicable state and local fair employment practice laws and wage and hour laws; (iv) any other claims under any federal, state or local common law, statutory, or regulatory provision, now or hereafter recognized;
and (v) any claims for attorneys’ fees and costs. 
 2. The foregoing shall in no event apply to (i) enforcement by Executive
of Executive’s rights under this Agreement, (ii) Executive’s rights as a stockholder in Company or any of its affiliates, (iii) Executive’s rights to indemnifications under any separate contract or insurance policy,
(iv) Executive’s right to seek unemployment insurance benefits, (v) Executive’s right to seek workers’ compensation benefits, (vi) any rights Executive has to indemnification for service as an officer of Company, or
(vii) any claims that, as a matter of applicable law, are not waivable. This Agreement is effective without regard to the legal nature of the claims raised and without regard to whether any such claims are based upon tort, equity, implied or
express contract or discrimination of any sort. 

  
 - 18 - 

 Executive and Company agree that nothing in this Agreement prevents or prohibits Executive from
(i) making any disclosure of relevant and necessary information or documents in connection with any charge, action, investigation, or proceeding relating to this Agreement, or as required by law or legal process; (ii) participating,
cooperating, or testifying in any charge, action, investigation, or proceeding with, or providing information to, any self-regulatory organization, governmental agency or legislative body, and/or pursuant to the Sarbanes-Oxley Act,
(iii) filing, testifying, participating in or otherwise assisting in a proceeding relating to an alleged violation of any federal, state or municipal law relating to fraud, or any rule or regulation of the Securities and Exchange Commission or
any self-regulatory organization or (iv) challenging the knowing and voluntary nature of the release of ADEA claims pursuant to the OWBPA. To the extent permitted by law, upon receipt of any subpoena, court order or other legal process
compelling the disclosure of any such information or documents, Executive agrees to give prompt written notice to Company so as to permit Company to protect its interests in confidentiality to the fullest extent possible. To the fullest extent
provided by law, Executive acknowledges and agrees, however, Executive is waiving any right to recover monetary damages in connection with any such charge, action, investigation or proceeding. To the extent Executive receives any monetary relief in
connection with any such charge, action, investigation or proceeding, Company will be entitled to an offset for the benefits made pursuant to this Agreement, to the fullest extent provided by law. 

Executive and Company further agree that the Equal Employment Opportunity Commission (“EEOC”) and comparable state or local
agencies have the authority to carry out their statutory duties by investigating charges, issuing determinations, and filing lawsuits in Federal or state court in their own name, or taking any action authorized by the EEOC or comparable state or
local agencies. Executive retains the right to participate in any such action and to seek any appropriate non-monetary relief. Executive retains the right to communicate with the EEOC and comparable state or local agencies and such communication can
be initiated by Executive or in response to the government and such right is not limited by any non-disparagement claims. Executive and Company agree that communication with employees plays a critical role in the EEOC’s enforcement process
because employees inform the agency of employer practices that might violate the law. For this reason, the right to communicate with the EEOC is a right that is protected by federal law and this Agreement does not prohibit or interfere with those
rights. Notwithstanding the foregoing, Executive agrees to waive Executive’s right to recover monetary damages in any charge, complaint or lawsuit filed by Executive or by anyone else on Executive’s behalf. 

3. In consideration of Executive’s agreement to comply with the covenants described in Section 6-10 of the Employment Agreement,
Company agrees as set forth in paragraph 6 herein. 
 4. Executive further agrees and recognizes that Executive has permanently and
irrevocably severed Executive’s employment relationship with Company, that Executive shall not seek employment with Company or any affiliated entity at any time in the future, and that neither Company nor any affiliate has any obligation to
employ Executive in the future. 
 5. Executive agrees that Executive will not disparage or subvert Company or the Releasees, or make any
statement reflecting negatively on Company or the Releasees, including, but not limited to, any matters relating to the operation or management of Company, Executive’s employment and the termination of Executive’s employment, irrespective
of the truthfulness or falsity of such statement. 
 6. In consideration for Executive’s agreement as set forth herein, Company agrees
to pay and provide Executive with the severance benefits described in Section 4(E)(1) of Executive’s Employment 

  
 - 19 - 

 
Agreement. Executive agrees that Executive is not entitled to any payments, benefits, severance payments or other compensation beyond that expressly provided in Section 4(E)(1) of
Executive’s Employment Agreement and the Accrued Benefits (as defined in Section 4(B) of the Employment Agreement). 
 7.
Executive understands and agrees that the payments, benefits and agreements provided in this Agreement are being provided to Executive in consideration for Executive’s acceptance and execution of, and in reliance upon Executive’s
representations in, this Agreement. Executive acknowledges that if Executive had not executed this Agreement containing a release of all claims against Company and the Releasees, Executive would only have been entitled to the payments provided in
Company’s standard severance pay plan for employees. 
 8. Executive acknowledges and agrees that Company previously has satisfied any
and all obligations owed to Executive under any employment agreement or offer letter Executive has with Company or a Releasee and, further, that this Agreement supersedes any and all prior agreements or understandings, whether written or oral,
between the parties, excluding only Executive’s and Company’s post-termination obligations under Executive’s Employment Agreement, Executive’s rights under any outstanding equity grants in accordance with the terms of the
applicable grant agreements, any obligations relating to the securities of Company or any of its affiliates and Company’s obligations under Section 4(E)(1) of Executive’s Employment Agreement and to pay or provide the Accrued Benefits
(as defined in Section 4(B) of the Employment Agreement), all of which shall remain in full force and effect to the extent not inconsistent with this Agreement, and further, that, except as set forth expressly herein, no promises or
representations have been made to Executive in connection with the termination of Executive’s Employment Agreement or the terms of this Agreement. 

9. Except as may be necessary to obtain approval or authorization to fulfill Executive’s or its obligations hereunder or as required by
applicable law and subject to the exceptions of Section 2 of the Agreement, (a) Executive agrees not to disclose the terms of this Agreement to anyone, except Executive’s spouse, attorney and, as necessary, tax/financial advisor, and
(b) Company agrees that the terms of this Agreement will not be disclosed. It is expressly understood that any violation of the confidentiality obligation imposed hereunder constitutes a material breach of this Agreement. 

10. Executive represents that Executive does not presently have in Executive’s possession any records and business documents, whether on
computer or hard copy, and other materials (including but not limited to computer disks and tapes, computer programs and software, office keys, correspondence, files, customer lists, technical information, customer information, pricing information,
business strategies and plans, sales records and all copies thereof) (collectively, the “Corporate Records”) provided by Company and/or its predecessors, parents, subsidiaries or affiliates or obtained as a result of
Executive’s employment with Company and/or its predecessors, parents, subsidiaries or affiliates, or created by Executive while employed by or rendering services to Company and/or its predecessors, parents, subsidiaries or affiliates. Executive
acknowledges that all such Corporate Records are the property of Company. In addition, Executive shall promptly return in good condition any and all Company owned equipment or property, including, but not limited to, automobiles, personal data
assistants, facsimile machines, copy machines, pagers, credit cards, cellular telephone equipment, business cards, laptops and computers. As of the Termination Date, Company will make arrangements to remove, terminate or transfer any and all
business communication lines including network access, cellular phone, fax line and other business numbers. 
 11. Subject to the exceptions
of Section 2 of the Agreement, Executive expressly waives all rights afforded by any statute which expressly limits the effect of a release with respect to unknown claims. Executive acknowledges the significance of this release of unknown
claims and the waiver of 

  
 - 20 - 

 
statutory protection against a release of unknown claims which provides that a general release does not extend to claims which the creditor does not know or suspect to exist in Executive’s
favor at the time of executing the release, which if known by it must have materially affected its settlement with the debtor. 
 12. The
parties agree and acknowledge that the agreements by Company described herein, and the settlement and termination of any asserted or unasserted claims against the Releasees, are not and shall not be construed to be an admission of any violation of
any federal, state or local statute or regulation, or of any duty owed by any of the Releasees to Executive. 
 13. Executive agrees and
recognizes that should Executive breach any of the obligations or covenants set forth in this Agreement, Company will have no further obligation to provide Executive with the consideration set forth herein, and will have the right to seek repayment
of all consideration paid up to the time of any such breach. Further, Executive acknowledges in the event of a breach of this Agreement, Releasees may seek any and all appropriate relief for any such breach, including equitable relief and/or money
damages. 
 14. This Agreement and the obligations of the parties hereunder shall be construed, interpreted and enforced in accordance with
the laws of the State of Iowa. 
 15. Executive certifies and acknowledges as follows: 

(a) That Executive has read the terms of this Agreement, and that Executive understands its terms and effects, including the fact that
Executive has agreed to RELEASE AND FOREVER DISCHARGE Company and each of the Releasees from any legal action arising out of Executive’s employment relationship with Company and the termination of that employment relationship; 

(b) That Executive has signed this Agreement voluntarily and knowingly in exchange for the consideration described herein, which Executive
acknowledges is adequate and satisfactory to Executive and which Executive acknowledges is in addition to any other benefits to which Executive is otherwise entitled; 

(c) That Executive has been and is hereby advised in writing to consult with an attorney prior to signing this Agreement; 

(d) That Executive does not waive rights or claims that may arise after the date this Agreement is executed; 

(e) That Company has provided Executive with a period of [twenty-one (21)] or [forty-five (45)] days within which to
consider this Agreement, and that Executive has signed on the date indicated below after concluding that this Separation of Employment Agreement and General Release is satisfactory to Executive; and 

[Note: The applicable time period will depend on whether the termination is part of a reduction in force (45 days) or not (21 days). In addition, if the
termination is in connection with a reduction in force, certain disclosures will need to be made to Executive to comply with the requirements of the ADEA if Executive is at least age 40.] 

(f) Executive acknowledges that this Agreement may be revoked by Executive within seven (7) days after execution, and it shall not become
effective until the expiration of such seven (7) day revocation period. In the event of a timely revocation by Executive, this Agreement will be deemed null and void and Company will have no obligations hereunder. Revocation may be achieved
only by delivering a letter to [NAME, TITLE, ADDRESS], clearly evidencing a decision to revoke within the seven day revocation period. 

  
 - 21 - 

 Intending to be legally bound hereby, Executive and Company executed the foregoing Separation of
Employment Agreement and General Release this             day of             ,
            . 
  

					
	  
	 		 	Witness:                                    
                                         
           
	Christal Mickle	 		 	
			
	KEMPHARM, INC.	 		 	
			
	By:                                     
                                         
                  	 		 	Witness:                                    
                                         
           
	Name:	 		 	
	Title:	 		 	

  
 - 22 -EX-10.22

 EXHIBIT 10.22 

BOARD OF DIRECTORS SERVICES AGREEMENT 

This Board of Directors Services Agreement (this “Agreement”) is effective as of January 1, 2014 (the “Effective
Date”) by and between KemPharm, Inc., an Iowa corporation (the “Company”), and Richard W. Pascoe, an individual with a principal place of residence in San Diego County, California (the “Director”) (each a
“Party” and together, the “Parties”). 
 WHEREAS, the Company desires to retain the
services of the Director for the benefit of the Company and its stockholders; and 
 WHEREAS, the Director desires to serve
on the Company’s Board of Directors (the “Board”) for the period of time and subject to the terms and conditions set forth herein; 

NOW, THEREFORE, in consideration of the above recited promises and the mutual agreements and covenants of the
Company and the Director contained herein, the Parties hereby agree as follows: 
 1. DUTIES AND
EXTENT OF SERVICES. Commencing as of the Effective Date, the Director agrees to provide services to the Company as a member of the Board. For so long as he serves as a member of the
Board, the Director shall perform those services and duties that are required of a director under the Company’s articles of incorporation and bylaws, as both may be amended and restated from time to time (the “Articles and
Bylaws”), and under the Iowa Business Corporation Act, Chapter 490 of the Code of Iowa, as amended (the “Iowa Business Corporation Act”), and other state and federal laws and regulations, as applicable, and shall render
such services as are customarily associated with and are incident to the position of a director of a for-profit corporation and such other services as the Company, from time to time, may reasonably require of him consistent with such position.
Without limiting the preceding sentence, the Company acknowledges that the Director has other business commitments, including commitments to serve as an officer and employee of Apricus Biosciences, Inc. and its affiliates and as a director of other
companies. The Director shall promptly disclose to the Company’s president or general counsel any actual, apparent or potential conflicts of interest that arise from time to time with respect to the Director’s service on the Board. 

2. COMPENSATION. 

(a) Cash Stipend. 

(1) Board Service. As compensation for the Director’s entering into this Agreement and performing his services as a
member of the Board, the Company shall pay to the Director on a quarterly basis a cash stipend in an annualized amount of $25,000 with the first quarterly payment due at the end of the first quarter of the Company’s 2014 fiscal year. The
Company shall continue to pay the quarterly cash stipend due hereunder through and until the last fiscal quarter during which the Director served on the Board, after which no further stipend amounts shall be due under this Agreement. Payments shall
be made in accordance with the Company’s regular accounting practices. 
 (2) Committee Service. For any fiscal
quarter of the Company during which the Director serves on any of the following Board committees, the quarterly stipend payable at the end of such quarter shall be increased by the following annualized amounts: (i) service on the Board’s
compensation committee as chair shall increase the stipend by an annualized amount of $5,000; (ii) service on the Board’s compensation committee other than as chair shall increase the stipend by an annualized amount of $1,500;
(iii) service on the Board’s nominating and governance committee as chair shall increase the stipend by an annualized amount of $2,500; and (iv) service on the Board’s governance committee other than as chair shall increase the
stipend by an annualized amount of $1,500. 

  
 - 1 - 

 (b) Stock Options. As additional compensation for the Director entering
into this Agreement and performing his services as a member of the Board, the Company shall grant to the Director options to purchase shares of the Company’s common stock which are consistent with the following terms. Such option grants shall
be made pursuant to the Company’s incentive stock plan and shall be treated by the Parties as nonqualified stock options for federal income tax purposes. Each option grant shall be memorialized in a written agreement (the “Option
Agreements”) with terms and conditions that are satisfactory to the Company and substantially consistent with the terms and conditions of option grants issued to other Board members. 

(1) Effective as of the Effective Date, the Company shall grant to the Director the right to purchase up to 55,000 shares of
the Company’s common stock. The price per share at which shares may be purchased pursuant to this grant shall be the fair market value of a share of the Company’s common stock as of the Effective Date as determined by the Company’s
Board. The Director’s purchase option under this grant shall vest in accordance with the following: 
 (i) The right to
purchase 45,000 shares shall vest in, increments of one-third on each of the following vesting dates if the Director is still serving as a Board member on such vesting date: December 31, 2014, December 31, 2015 and December 31,
2016; 
 (ii) The right to purchase 5,000 shares shall vest upon the sale by the Company of shares of its capital stock
pursuant to one or a series or related private placement offerings exempt from registration under the Securities Act of 1933, as amended, with sale proceeds of at least. $5,000,000 in the aggregate. This vesting rule shall apply only to the first
such private placement offering with respect to which such aggregate amount has been met to occur after the Effective Date; and 

(iii) The right to purchase 5,000 shares shall vest upon the closing of the Company’s sale of shares of its common stock
to the public in an underwritten public offering pursuant to a registration statement under the Securities Act of 1933, as amended, if the proceeds of such sale exceed $15,000,000 and in connection therewith the Company’s common stock becomes
publicly traded on the New York Stock Exchange, American Stock Exchange or Nasdaq Stock Market. 
 (2) Effective as of the
date of each annual meeting of the Company’s shareholders, commencing with the annual meeting in 2015, the Company shall grant to the Director the right to purchase up to 25,000 shares of the Company’s common stock if the Director has
continuously served as a member of the Board up until the date of such meeting. The price per share at which shares may be purchased pursuant to this grant shall be the fair market value of a share of the Company’s common stock as of the
effective date of the grant as determined by the Company’s board. The Director’s purchase option under this grant shall vest in increments of one-third over a period of three (3) years subject to the Director’s continued service
as a Board member during such period. 
 (c) Other Benefits. While the Director serves as a member of the Board, the
Director shall be entitled to any other benefits made available to all of the other non-executive members of the Board generally. 

  
 - 2 - 

 3. EXPENSE REIMBURSEMENT. The Company agrees
to reimburse the Director for all reasonable and necessary travel, business entertainment and other out-of-pocket business expenses incurred by him in connection with the performance of his duties as a Board member upon receipt of substantiating
documentation relating to such expenses as the Company may reasonably require. Unless the Company otherwise pre-authorizes, the Director shall have the Company make any airplane and hotel reservations related to the Director’s service as a
Board member, and the Director shall comply with such other reasonable expense policies and practices that the Company imposes on Board members. 

4. TERMINATION. The Director shall have the right, exercisable at any time, to resign as a Board member.
The Company and its shareholders shall have the right to not reelect the Director to the Board or to remove the Director from the Board to the fullest extent permitted under the Articles and Bylaws and under the Iowa Business Corporation Act. The
Parties rights and obligations under Sections 2, 3, 5 - 7 hereof and under the Option Agreements shall survive any termination of the Director’s service as a Board member, provided that Sections 2 and 3 shall survive only to the extent
necessary to allow Director to be compensated and have expenses reimbursed relating to the pre-termination period. 
 5.
LIMITATION OF LIABILITY AND INDEMNIFICATION. 

(a) To the fullest extent permitted under the Articles and Bylaws and the Iowa Business Corporation Act, the Director shall not
be personally liable to the Company or its shareholders for monetary damages for any act of omission in connection with the performance of his services as a Board member, and the Company shall indemnify the Director against and hold him harmless
from any liability to third parties by reason of the fact that he was a Board member. Without limiting the generality of the foregoing, the Company shall indemnify Director to the fullest extent permitted by law against all Expenses, judgments,
fines, penalties and amounts paid in settlement (including all interest, assessments and other charges paid or payable in connection with or in respect of such Expenses, judgments, fines, penalties and amounts paid in settlement) actually and
reasonably incurred by Director or on his behalf in connection with any Proceeding or any claim, issue or matter therein, if Director acted in good faith and in a manner he reasonably believed to be in or not opposed to the best interests of the
Company. 
 (b) Notwithstanding any other previsions of this Agreement :except Section 5(d), to the extent that Director
is a party to (or a participant in) and is successful, on the merits or otherwise, in any Proceeding or in defense of any claim, issue or matter therein, in whole or in part, the Company shall indemnify Director against all Expenses actually and
reasonably incurred by him in connection therewith. If Director is not wholly successful in such Proceeding but is successful, on the merits or otherwise, as to one or more but less than all claims, issues or matters in such Proceeding, the Company
shall indemnify, to the fullest extent permitted by law, Director against all Expenses actually and reasonably incurred by him or on his behalf in connection with each successfully resolved claim, issue or matter. If Director is not wholly
successful in such Proceeding, the Company also shall indemnify, to the fullest extent permitted by law, Director against all Expenses reasonably incurred in connection with a claim, issue or matter related to any claim, issue or matter on which
Director was successful. For purposes of this Section 5 and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with or without prejudice, shall be deemed to be a successful result as to such
claim, issue or matter. 

  
 - 3 - 

 (c) Notwithstanding any provision of this Agreement to the contrary except
Section 5(d), the Company shall advance the Expenses incurred by Director in connection with any Proceeding in accordance with the Company’s standard accounting practice after the receipt by the Company of a statement or statements
requesting such advances from time to time, whether prior to or after final disposition of any Proceeding. Advances shall be unsecured and interest free. Advances shall be made without regard to Director’s ability to repay the expenses and
without regard to Director’s ultimate entitlement to indemnification hereunder or under the Articles and Bylaws or any applicable law. Advances shall include any and all reasonable Expenses incurred pursuing an action to enforce this right of
advancement, including. Expenses incurred preparing and forwarding statements to the Company to support the advances claimed. Director shall qualify for advances solely upon the execution and delivery to the Company of (i) an undertaking
providing that Director undertakes to repay all advances to the extent that it is ultimately determined by a final decision by a court of competent jurisdiction that Director is not entitled to be indemnified by the Company, and (ii) an
affirmation of the Director’s good faith belief that he has met the applicable standard of conduct that is necessary to be entitled to indemnification by the Company. 

(d) Notwithstanding any other provisions of this Agreement, if Director intends to seek indemnification of Expenses, judgments,
fines penalties or other amounts from the Company with respect to any Proceeding, except a Proceeding brought by or in the right of the Company, then he shall promptly notify the Company after he first becomes aware of such Proceeding. The Company
shall thereafter have the right to assume the defense of Director in such Proceeding with counsel selected by the Company. If the Company elects to assume such defense, then the Company shall not be liable to Director for any fees or Expenses of any
separate counsel retained. by Director, except as provided in the following sentence. In the event that (i) the Company fails to assume the defense of a Proceeding, or (ii) in a Proceeding the Director reasonably determines that having
counsel selected by the Company would constitute an unwaivable conflict of interest, then Director may engage separate legal counsel reasonably acceptable to the Company to represent and defend Director in such proceeding, and the Company shall
indemnify Director for the fees and Expenses of such counsel in accordance with this Section 5. 
 (e) The Company shall
not settle any action, claim or Proceeding (in whole or in part) which would impose any Expense, judgment, fine, penalty or limitation on Director without Director’s prior written consent. The Director shall not settle, without the
Company’s prior written consent, any action, claim or Proceeding (in whole or in part) which would impose any judgment, fine, penalty, monetary damages or other amount payable in settlement from which the Company is required to indemnify
Director. 
 (f) The rights of indemnification and to receive advancement of Expenses as provided by this Agreement shall not
be deemed exclusive of any other rights to which Director may at any time be entitled under applicable law, the Articles and Bylaws, any agreement, a vote of stockholders, a resolution of directors or otherwise. No amendment, alteration or repeal of
this Agreement or of any provision hereof shall limit or restrict any right of Director under this Agreement in respect of any action taken or omitted by such Director prior to such amendment, alteration or repeal. To the extent that a change in
Iowa law, whether by statute or judicial decision, permits greater indemnification or advancement of Expenses than would be afforded currently under the Articles and Bylaws and this Agreement, it is the intent of the parties hereto that Director
shall enjoy by this Agreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right and remedy shall be cumulative and in addition to
every other right and remedy given hereunder or now or hereafter existing at law, in equity or otherwise. The assertion or employment of any right or remedy hereunder or otherwise, shall not prevent the concurrent assertion or employment of any
other right or remedy. 

  
 - 4 - 

 (g) The Company shall maintain director and officer liability insurance in
amounts and on terms that the Board determines is customary for companies in the pharmaceutical industry of similar size, operations, capital structure and regulatory environment to the Company (“D&O Insurance”). Director shall
be covered by such D&O Insurance, and each other similar insurance policy or policies providing liability insurance for directors or fiduciaries of the Company, in accordance with its or their terms to the maximum extent of the coverage
available under such policy or policies. At the time the Company receives notice from any source of a Proceeding as to which Director is a party or a participant (as a witness or otherwise), the Company shall give prompt notice of such Proceeding to
the insurers in accordance with the procedures set forth in the respective policies. The Company shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of Director, all amounts payable as a result of such
Proceeding in accordance with the terms of such policies. 
 (h) For purposes of this Agreement, “Expenses” shall
mean all reasonable attorneys’ fees, retainers, court costs, transcript costs, fees of experts, witness fees, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees and all other
disbursements or expenses of the type customarily incurred in connection with prosecuting, defending, preparing to prosecute or defend, investigating, being or preparing to be a witness in, or otherwise participating in, a Proceeding. Expenses also
shall include Expenses incurred in connection with any appeal resulting from any Proceeding, including, without limitation, the premium, security for and other costs relating to any cost bond, supersedeas bond or other appeal bond or its equivalent.

 (i) For purposes of this Agreement, “Proceeding” shall include any threatened, pending or completed action,
suit, arbitration, alternate dispute resolution mechanism, investigation, formal or informal inquiry, administrative hearing, request for documents or information, subpoena, or any other actual, threatened or completed, proceeding, whether brought
in the right of the Company or otherwise and whether of a civil, criminal, administrative or investigative nature, in which Director was, is or will be involved as a party, witness or otherwise by reason of the fact that Director is or was a
director or fiduciary of the Company, by reason of any action taken (or failure to act) by him or of any action (or failure to act) on his part while acting as a director or fiduciary of the Company, or by reason of the fact that he is or was
serving at the request of the Company as a director, officer, trustee, general partner, manager, member, fiduciary, employee or agent, in each case whether or not serving in such capacity at the time any liability or Expenses are incurred for which
indemnification, reimbursement or advancement of Expenses can be provided under this Agreement. 
 6. CONFIDENTIALITY
OBLIGATIONS. 
 (a) Definition of Confidential Information. As used in this
Agreement, the Company’s “Confidential Information” means any proprietary information of the Company (or any subsidiary or parent company) which is disclosed to the Director in the course of the performance of his services as a
Board member and which was not or is not in the public domain at the time of its disclosure to the Director, whether or not in writing, and whether or not marked as “confidential” or “proprietary” by the Company.
“Confidential Information” includes, without limitation, all of the following types of information, written or verbal, to the extent such information is not in the public domain at the time of its disclosure to the Director, whether or not
in writing or marked as “confidential” or “proprietary”: any information and comments disclosed 

  
 - 5 - 

 
at meetings of the Board or Board committees; any information, comments and advice disclosed by or to the Company’s attorney(s) within any attorney-client communication; information set
forth within all business, strategic and development plans; financial information; business and employment records and relationships; employee and advisor lists; discoveries and inventions; ideas; concepts; specifications; designs; diagrams;
drawings; models; flow charts; chemical and molecular structures; synthetic pathways and techniques; development routes; manufacturing processes; data (biological, safety, clinical, developmental, analytical and/or other kinds of data); records and
ideas constituting, arising from or relating to research and development; invention disclosures; work papers and materials supporting or underlying patents and patent applications; trade secrets, know-how; co-developer identities; and the existence
and terms of agreements between the Company and one or more third parties (including, without limitation, any agreements between the Company and Shire LLC). The Company’s Confidential Information may include Confidential Information that the
Company has obtained from a third party under a duty of confidentiality. 
 (b) Nondisclosure and Non-Use Covenants.
The Director acknowledges that the unlawful use or disclosure of Confidential Information received from the Company may cause irreparable damage and financial loss to the Company. Accordingly, the Director agrees that while he is a member of the
Company’s Board and for a period of five (5) years following the earliest date on which the Director is no longer a member of the Board, he will: (i) protect the confidentiality and prevent the unauthorized use or disclosure of all
Confidential Information with at least the same degree of care that the Director uses to protect his own proprietary, confidential information, but in no case less than reasonable care; (ii) not disclose any Confidential Information nor make
any use of Confidential Information except as necessary and directly related to the performance of his services as a Board member; (iii) not intentionally use the Confidential Information in any way that is detrimental to the Company; and
(iv) not disclose Confidential Information to any other person who is not an officer, director, outside counsel or public accounting firm of the Company without the prior written consent of the Company’s president or the chairman of the
Board. 
 (c) Exceptions. The Director’s confidentiality obligations set forth above in Section 6(b) shall
not apply to any Confidential Information which: 
 (1) is or later becomes generally available to the public without breach
of any obligation of confidentiality by the Director; 
 (2) written evidence reasonably confirms was in the possession of
the Director prior to its receipt from the Company; 
 (3) is later acquired by the Director from a third party without any
restriction on disclosure or breach of an obligation of confidentiality; 
 (4) the Director can demonstrate that the
Director independently created such information without reference or use of Confidential Information; or 
 (5) the Director
is required to disclose pursuant to any governmental order, law or other valid legal process, provided, however that: (i) to the extent possible without violating any such order, law or other valid legal process, prior to such disclosure the
Director shall provide the Company with prompt written notice of the requirement so that the Company may object to such disclosure or to seek a protective order or other appropriate remedy and/or waive the Director’s compliance with the
provisions of this Agreement; and (ii) if, in the absence of a protective order or the receipt of a waiver 

  
 - 6 - 

 
hereunder, the Director, in the opinion of the Director’s legal counsel, is compelled to disclose Confidential Information of the Company to any tribunal or else stand liable for contempt or
suffer some other censure or penalty, the Director shall disclose only that portion of such Confidential Information which the Director’s counsel advises it is legally required to disclose to such tribunal without liability under this
Agreement. 
 (d) Return of Confidential Information. Promptly upon the request of the Company after termination of
the Director’s service as a Board member, the Director, shall cease any and all further use or disclosure of the Confidential Information and, at his election, either return or destroy all copies of any media or materials containing the
Company’s Confidential Information, including all documentation, notes, plans, drawings, computer records and copies of the foregoing; provided, however, that (i) the Director may retain one copy of such Confidential Information for his
legal files solely for the purpose of monitoring compliance with applicable confidentiality obligations pursuant to this Agreement, and (ii) the obligation to return or destroy Confidential Information shall not cover information the Director
maintains on routine computer system backup tapes, disks or other backup storage devices as long as such back-up information is not used, disclosed, or otherwise recovered from such backup devices. Notwithstanding the Director’s retention of
Confidential Information for his legal files, the Director will continue to be bound by the confidentiality and other obligations under this Agreement. 

(e) Remedies. The Director understands and acknowledges that the actual or threatened disclosure or misappropriation, of
any of the Confidential Information in violation of this Agreement may cause the Company irreparable harm, the amount of which may be difficult to ascertain and, therefore, agrees that the Company shall have the right to apply to a court of
competent jurisdiction for an order restraining any such further disclosure or misappropriation and for other such relief as the Company may deem appropriate. Such right of the Company shall be in addition to remedies otherwise available to the
Company at law or in equity, including, without limitation, all rights and remedies of the Company under its Articles and Bylaws and the Iowa Business Corporation Act. 

7. INDEPENDENT CONTRACTOR STATUS. The Director shall be an independent
contractor of the Company. No terms of this Agreement shall be construed to confer employment status upon the Director, and the Director shall not be entitled to workers’ compensation coverage, unemployment insurance benefits or any employee
benefits provided by the Company to its employees. The Director shall be solely responsible for the payment of all required taxes due for the compensation paid hereunder, whether federal, state or local in nature, including but not limited to,
income taxes, social security taxes, unemployment compensation taxes, and any other assessments. 
 8. REPRESENTATION
BY DIRECTOR. The Director represents and warrants to the Company that his service on the Board and the terms of this Agreement do not conflict with or breach any other contractual or legal obligations
that the Director may have. 
 9. REPRESENTATION BY COMPANY. The Company
represents and warrants to the Director that the execution, delivery and performance by the Company of this Agreement and the Option Agreements have been duly authorized by all necessary corporate action on the part of the Company to make this
Agreement and the Option Agreements valid and binding upon the Company in accordance with their respective terms. 
 10.
GOVERNING LAW; VENUE. This Agreement shall be governed by and construed in accordance with the laws of the State of Iowa, without reference to principles of conflict of laws. The
Director hereby irrevocably consents to the exclusive jurisdiction of the courts of the State of Iowa and the United States District Court for the Southern District of Iowa, and the respective appellate courts for such courts, for the purpose of any
suit, action or other proceeding arising out of the Parties’ obligations and performances under this Agreement, and expressly waives any and all objections he may have to venue in such courts. 

  
 - 7 - 

 11. AMENDMENT AND WAIVER. This
Agreement may not be amended except by a written instrument signed both by Parties which specifically refers to the particular provision or provisions being amended. No provision of this Agreement may be waived except in a written instrument that
specifically refers to the particular provision or provisions being waived and is signed by the Party against whom the waiver is being asserted. No waiver by any Party of any right, power or privilege hereunder shall constitute a waiver of any other
right, power or privilege hereunder, and no waiver by any party of any breach of a provision hereunder shall constitute a waiver of any other breach of that or any other provision of this Agreement. 

12. NOTICES. All notices, requests, demands and other communications provided in connection with this
Agreement shall be in writing and may be delivered to each Party by hand, deposited with an overnight courier, sent by confirmed email or confirmed facsimile or mailed, in each case to the address, email address, telephone number or facsimile number
set forth below such Party’s signature hereto or such other address as may hereafter be furnished in writing. Such notice shall be deemed to have been given as of (i) the date on which it is delivered, in the case of notice given by hand
delivery, overnight courier or email, (ii) the date on which transmission confirmation is received in the case of notice given by facsimile, and (iii) three (3) days after such notice is deposited in the U.S. mail. 

13. SEVERABILITY. If any term or other provision of this Agreement is held to be illegal, invalid or
unenforceable by any rule of law or public policy, the remaining provisions of this Agreement shall remain in full force and effect and shall not be affected by such illegal, invalid or unenforceable provision or by its severance from this
Agreement. If any provision of this Agreement is so broad as to be unenforceable, the provision shall be interpreted to be only as broad as is enforceable. 

14. RULES OF CONSTRUCTION. Headings to sections and paragraphs of this
Agreement are for reference only, and do not form a part of this Agreement, or effect the interpretation of this Agreement. Whenever the context of this Agreement requires, a reference to any gender includes each other gender, and the singular
number includes the plural and vice versa. 
 15. ENTIRE AGREEMENT; CONFLICTING
TERMS AND CONDITIONS. This Agreement and the Option Agreements constitute the entire agreement and understanding of the Parties with respect to the subjects matter hereof; provided,
however, that the terms and conditions of this Agreement shall not be deemed to eliminate or reduce any fiduciary duties of the Director under the Articles and Bylaws and/or the Iowa Business Corporation Act. In the event of any conflict between the
terms and conditions of this Agreement and the terms and conditions of the Articles and Bylaws and/or the provisions of the Iowa Business Corporation Act with respect to the Director’s duties to the Company and its shareholders and/or his
confidentiality obligations and/or the rights and remedies of the Company and its shareholders with respect to the Director’s breach of any duty or contractual obligation to the Company and its shareholders, the conflicting term, condition or
provision which is more favorable to the Company shall apply. 
 16. COUNTERPARTS. This Agreement may
be executed in any number of counterparts, including by transmission of facsimile or PDF copies of signature pages, each of which shall be deemed for all purposes to be an original and all of which taken together shall constitute one instrument. All
signatures of the Parties transmitted by facsimile or PDF shall be deemed to be their original signatures for all purposes. 
 [Signature
Page Follows] 

  
 - 8 - 

 SIGNATURE PAGE 

TO 

BOARD OF DIRECTORS SERVICES AGREEMENT 

IN WITNESS WHEREOF, the Parties hereby acknowledge having entered into this Agreement. 

 

					
	DIRECTOR:				 COMPANY:
 KemPharm,
Inc.

			
	/s/ Richard W. Pascoe		By:		/s/ Travis C. Mickle
	Richard W. Pascoe				Travis C. Mickle, President

  

									
	Address:						Address:		 2656 Crosspark Road, Suite 100
 Coralville,
IA 52241

					
	Email:						Email:		
					
	Facsimile:		(858) 866-0482				Facsimile:		(319) 665-2577

  
 - 9 -

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