Document:

EX-10.1

 Exhibit 10.1 
 INVESTOR RIGHTS AGREEMENT 
 This INVESTOR RIGHTS AGREEMENT (the
“Agreement”) is made as of August 8, 2013 by and among Hansen Medical, Inc., a corporation organized and existing under the laws of the State of Delaware (the “Company”), Oracle Partners, LP, Oracle Institutional
Partners, LP and Oracle Ten Fund Master, LP (together, “Oracle”), Schuler Family Foundation (the “Schuler Family Foundation” and together with Oracle, the “Principal Purchasers”) and the other
purchasers named in the Purchase Agreement (as defined below) (collectively, the “Purchasers”). 
 RECITALS

 WHEREAS, the Company and the Purchasers are parties to a Securities Purchase Agreement, dated as of July 30, 2013 (the
“Purchase Agreement”), pursuant to which the Purchasers are purchasing an aggregate of 28,455,284 shares of Common Stock (as defined below) (“Shares”), of the Company and Warrants (as defined in the Purchase
Agreement) to purchase an aggregate of 34,146,339 shares of Common Stock; and 
 WHEREAS, in connection with the consummation of
the transactions contemplated by the Purchase Agreement, and pursuant to the terms of the Purchase Agreement, the parties desire to enter into this Agreement in order to grant certain rights to the Purchasers as set forth below. 

NOW, THEREFORE, in consideration of the covenants and promises set forth herein, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 AGREEMENT 

1. Certain Definitions. Unless the context otherwise requires, the following terms, for all purposes of this Agreement, shall have
the meanings specified in this Section 1. 
 “Affiliate” has the meaning set forth in Rule 12b-2 of
the rules and regulations promulgated under the Exchange Act; provided, however, that for purposes of this Agreement, the Purchasers and their Affiliates, on the one hand, and the Company and its Affiliates, on the other, shall not be
deemed to be “Affiliates” of one another. 
 “Allowed Delay” has the meaning set forth in
Section 3.1(b)(ii). 
 “Beneficially Own,” “Beneficially Owned,” or
“Beneficial Ownership” have the meaning set forth in Rule 13d-3 of the rules and regulations promulgated under the Exchange Act. 
 “Board” means the board of directors of the Company. 

“Business Days” has the meaning ascribed to such term in the Purchase Agreement. 

 “Change of Control” means the consummation of any transaction or series of
related transactions involving (i) any purchase or acquisition (whether by way of tender offer, exchange offer, merger, consolidation, amalgamation, scheme or arrangement, acquisition, business combination or similar transaction or otherwise)
by any Person or group (within the meaning of 13(d)(3) of the Exchange Act) of any of (A) securities representing a majority of the outstanding voting power of the Company entitled to elect the Board or (B) the majority of the outstanding
Common Stock, (ii) any sale, lease, exchange, transfer, exclusive worldwide license or disposition of all or substantially all of the assets of the Company, taken together as a whole, to such Person or group, (iii) any merger,
consolidation, amalgamation, scheme or arrangement, acquisition, business combination or similar transaction in which the holders of shares of the Common Stock and any other securities of the Company having the ordinary power to vote in the election
of members of the Board of the Company and any securities convertible, exchangeable for or otherwise exercisable to acquire voting securities immediately prior to the transaction, as a group, do not hold securities representing a majority of the
outstanding voting power entitled to elect the board of directors of the surviving entity in such merger, consolidation, amalgamation, scheme or arrangement, acquisition, business combination or similar transaction or (iv) a liquidation,
dissolution or winding up of the Company. 
 “Closing Date” has the meaning ascribed to such term in the
Purchase Agreement. 
 “Common Stock” means shares of the common stock, par value $0.0001 per share, of the
Company. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Filing Deadline” has the meaning set forth in Section 3.1(a). 

“FINRA” means the Financial Industry Regulatory Authority. 

“Form S-3” means such form under the Securities Act as in effect on the date hereof or any successor or similar
registration form under the Securities Act subsequently adopted by the Commission that permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the Commission. 

“Free Writing Prospectus” means an issuer free writing prospectus, as defined in Rule 433 under the Securities Act,
relating to an offer of Registrable Securities. 
 “Fully Diluted Basis” means all outstanding Common Stock
assuming the exercise of all outstanding stock, warrants, rights, calls, options or other securities exchangeable or exercisable for, or convertible into, Common Stock without regard to any restrictions or conditions with respect to the
exercisability thereof. 
 “GAAP” has the meaning ascribed to such term in the Purchase Agreement. 

“Holder” means any person owning of record Registrable Securities that have not been sold to the public or any
transferee or assignee of record of such Registrable Securities to which the registration rights conferred by this Agreement have been transferred or assigned in accordance with Section 5.2 hereof. 

  
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 “Initiating Shelf Take-Down Holder” has the meaning set forth in
Section 3.1(c). 
 “Insolvency Event” means any of the following: (a) the Company files a
petition under any chapter of title 11 of the United States Code (the “Bankruptcy Code”) or commences a proceeding under any similar law in any other jurisdiction or any other similar law of any jurisdiction affecting
creditors’ rights; makes an assignment for the benefit of its creditors; or commences a proceeding for the appointment of a receiver, trustee, liquidator, custodian or conservator of itself or of the whole or substantially all of its property;
(b) a petition is filed against the Company under any chapter of the Bankruptcy Code or any proceeding is commenced under any similar law of any other jurisdiction, or any other similar law of any jurisdiction affecting creditors’ rights
or for the appointment of a receiver, trustee, liquidator, custodian or conservator of the Company or of the whole or substantially all of its property and such petition or the related proceeding remains undismissed for a period of 30 days; or the
Company by any act indicates its consent to, approval of or acquiescence in any such petition or proceeding; (c) a court of competent jurisdiction enters an order for relief against the Company under any chapter of the Bankruptcy Code or any
other similar law of any jurisdiction affecting creditors’ rights or enters an order, judgment or decree appointing or authorizing a receiver, trustee, liquidator, custodian or conservator of the Company or of the whole or substantially all of
its or their property; or a court of competent jurisdiction or a receiver, trustee, liquidator, custodian or conservator, under the provisions of any law for the relief or aid of debtors, assumes custody or control or takes possession of the Company
or of the whole or substantially all of the property of the Company; or (d) the Company admits in writing its inability, or is generally unable, to pay its debts as such debts become due. 

“Nasdaq” has the meaning ascribed to such term in the Purchase Agreement. 

“Participating Holder” means with respect to any registration, any Holder of Registrable Securities covered by the
applicable Registration Statement. 
 “Person” has the meaning ascribed to such term in the Purchase Agreement.

 “Principal Purchasers” has the meaning set forth in the preamble. 

“Prospectus” means the prospectus included in any Registration Statement, all amendments and supplements to such
prospectus, including pre- and post-effective amendments to such Registration Statement, and all other material incorporated by reference in such prospectus. 
 “Register,” “registered” and “registration” refer to a registration effected by preparing and filing a registration statement in compliance with the
Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 

“Registrable Securities” means shares of Common Stock held by the Purchasers (whether acquired prior to, on or following
the Closing Date), and any Common Stock issued as (or issuable upon the conversion or exercise of any warrant (including the Warrants), right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for
or in replacement of, any Common Stock, warrant, right or other security held by the Purchasers. Notwithstanding the foregoing, Registrable Securities shall not include any securities of the Company sold by any person to the public either pursuant
to a registration statement under the Securities Act or that is freely tradeable under Rule 144. 

  
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 “Registration Statement” means any registration statement of the Company
that covers Registrable Securities pursuant to the provisions of this Agreement filed with, or to be filed with, the SEC under the rules and regulations promulgated under the Securities Act, including the related Prospectus, amendments and
supplements to such registration statement, including pre- and post-effective amendments, and all exhibits and all material incorporated by reference in such registration statement. 

“Registration Expenses” has the meaning set forth in Section 3.3. 

“Representatives” shall mean the directors, officers, employees and independent contractors, agents or advisors
(including, without limitation, attorneys, accountants, and investment bankers) of the specified party or any of its Subsidiaries. 
 “Rule 144” means Rule 144 as promulgated by the SEC under the Securities Act, as such rule may be amended from time to time, or any similar successor rule that may be promulgated by the
SEC. 
 “SEC” or “Commission” means the Securities and Exchange Commission or any other
federal agency at the time administering the Securities Act. 
 “Securities Act” means the Securities Act of
1933, as amended, or any similar successor federal statute and the rules and regulations thereunder, all as the same shall be in effect from time to time. 
 “Shelf Registration Statement” has the meaning set forth in Section 3.1(a). 
 “Shelf Take-Down” has the meaning set forth in Section 3.1(c). 
 “Subsidiaries” means each corporation, limited liability company, partnership, association, joint venture or other business entity of which any party or any of its Affiliates owns,
directly or indirectly, more than 50% of the stock or other equity interest entitled to vote on the election of the members of the board of directors or similar governing body. 

“Transaction Documents” means this Agreement, the Purchase Agreement and the Warrants (as defined in the Purchase
Agreement), all exhibits and schedules thereto and hereto and any other documents or agreement executed in connection with the transactions contemplated hereunder or thereunder. 

2. Board Representation. 
 (a) The Company shall take all permissible corporate action such that on the Closing Date the size of the Board shall be increased by one (1) member, and Jack W. Schuler (“Schuler”)
shall be appointed to the Board as a member of the class whose initial term expires at the 2016 annual meeting of the Company’s stockholders. 

  
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 (b) After the Closing, the size of the Board shall initially be set at ten
(10) members. 
 (c) Subject to Section 2(a), from and after the Closing Date, the Company shall cause Schuler
(or, if Schuler is unavailable to continue to serve on the Board, such other person designated by Schuler and reasonably acceptable to the Company) to be nominated by the Company to serve on the Board (such director, the “Purchaser
Designee”) for so long as the Schuler Family Foundation (or an Affiliate thereof) has beneficial ownership of Shares, Warrants or Warrant Shares, in the aggregate, in an amount equal to at least fifty percent (50%) of the Shares and
Warrants issued to the Schuler Family Foundation on the Closing Date. In the event the Schuler Family Foundation (or an Affiliate thereof) no longer has beneficial ownership of Shares, Warrants or Warrant Shares in the amount set forth in this
Section 3(c), the Company may cause the Purchaser Designee to be replaced with a nominee acceptable to the Company. 
 (d) The Purchaser Designee shall, when up for election, subject to the terms hereof and applicable law, be the Company’s nominee to serve on the Board and the Company shall solicit proxies for the
Purchaser Designee to the same extent as it would for any of its other nominees to the Board. The Company’s proxy statement for the election of directors shall include the Purchaser Designee and the recommendation of the Board in favor of
election of the Purchaser Designee. 
 (e) For so long as such membership does not conflict with any applicable law or
regulation or listing requirement of Nasdaq or other securities exchange on which the Common Stock is listed for trading (as determined in good faith by the Board), the Purchaser Designee shall be entitled to serve as a member of, or observer to, at
such Purchaser Designee’s election, committees of the Board. 
 (f) Schuler may, and Schuler may request the Purchaser
Designee to, as the case may be, resign, at any time with or without cause. Any vacancy caused by the resignation of the Purchaser Designee shall only be filled with another Purchaser Designee. Any vacancy created by any removal of the Purchaser
Designee or an election of Schuler to defer appointing the Purchaser Designee shall also only be filled with another Purchaser Designee. The Company shall not take any action to remove the Purchaser Designee or fill a vacancy reserved for the
Purchaser Designee in each case without the consent of Schuler unless and until Schuler is no longer entitled to the Purchaser Designee in accordance with Section 2(c) above. 

(g) In addition to any other indemnification rights the Purchaser Designee has pursuant to the Transaction Documents and the
Company’s Certificate of Incorporation and Bylaws, the Purchaser Designee that serves on the Board shall have the right to enter into, and the Company agrees to enter into, an indemnification agreement, in a form reasonably satisfactory to the
Purchaser Designee, concurrent with such Purchaser Designee becoming a member of the Board. The Company shall maintain director and officer insurance covering the Purchaser Designee on the same terms and with the same amount of coverage as is
provided to other members of the Board. The Company shall reimburse the reasonable expenses incurred by the Purchaser Designee in connection with attending (whether in person or telephonically) all meetings of the Board or committees thereof or
other Company related 

  
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meetings to the same extent as all other members of the Board are reimbursed for such expenses (or, in case any such expense reimbursement policy shall apply only to non-employee directors, to
the same extent as all other non-employee directors). The Purchaser Designee shall be entitled to the same compensation for service on the Board, including, without limitation, cash fees, stock options, deferred share units, restricted stock and
other equity and equity-related awards, as is provided to other non-employee directors. 
 (h) The Company and the Purchasers
shall take or cause to be taken all lawful action necessary to ensure at all times as of and following the Closing Date that the Company’s Certificate of Incorporation and Bylaws are not inconsistent with the provisions of this Agreement and
the Transaction Documents or the transactions contemplated hereby or thereby. 
 3. Registration Rights. 

3.1 Shelf Registration. 
 (a) Registration Statements. On or prior to the date that is 270 days after the Closing Date (the “Filing Deadline”), the Company shall prepare and file with the SEC one
Registration Statement on Form S-3 (or, if Form S-3 is not then available to the Company, on such form of registration statement as is then available to effect a registration for resale of the Registrable Securities) for an offering to be made on a
continuous basis pursuant to Rule 415 under the Securities Act (the “Shelf Registration Statement”). Such Shelf Registration Statement shall include the aggregate amount of Registrable Securities (including the Shares and Warrant
Shares (as defined in the Purchase Agreement)) to be registered therein and the intended methods of distribution thereof, subject to the limitations of Form S-3. To the extent the rules and regulations of the Commission do not permit such Shelf
Registration Statement to include all of the Registrable Securities, the Company shall use its best efforts to register the maximum amount permitted by the Commission and the Registrable Securities required to be omitted from such Registration
Statement shall be determined in the sole discretion of the Principal Purchasers. 
 (b) Effectiveness. 

(i) The Company shall use reasonable best efforts to have the Registration Statement declared effective as soon as practicable. The
Company shall notify the Purchasers by facsimile or e-mail as promptly as practicable, and in any event, within twenty-four (24) hours, after any Registration Statement is declared effective and shall simultaneously provide the Purchasers with
copies of any related Prospectus to be used in connection with the sale or other disposition of the securities covered thereby. 
 (ii) For not more than twenty (20) consecutive days or for a total of not more than forty-five (45) days in any twelve (12) month period, the Company may suspend the use of any Prospectus
included in any Registration Statement contemplated by this Section in the event that the Company determines in good faith that such suspension is necessary to (A) delay the disclosure of material non-public information concerning the Company,
the disclosure of which at the time is not, in the good faith opinion of the Company, in the best 

  
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interests of the Company or (B) amend or supplement the affected Registration Statement or the related Prospectus so that such Registration Statement or Prospectus shall not include an
untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in the case of the Prospectus in light of the circumstances under which they were made, not misleading
(an “Allowed Delay”); provided, that the Company shall promptly (a) notify each Purchaser in writing of the commencement of and the reasons for an Allowed Delay, but shall not (without the prior written consent of a
Purchaser) disclose to such Purchaser any material non-public information giving rise to an Allowed Delay, (b) advise the Purchasers in writing to cease all sales under the Registration Statement until the end of the Allowed Delay and
(c) use commercially reasonable efforts to terminate an Allowed Delay as promptly as practicable. 
 (c) Shelf
Take-Downs. An underwritten offering or sale of Registrable Securities pursuant to a Shelf Registration Statement (a “Shelf Take-Down”) may be initiated by a Principal Purchaser who is a Participating Holder (an
“Initiating Shelf Take-Down Holder”). Upon written request to the Company, the Company shall amend or supplement the Shelf Registration Statement for such purpose as soon as practicable. The Company shall send to each Participating
Holder in the Shelf Registration Statement written notice of such Shelf Take-Down and, if within 5 days after the date of such notice, any such Participating Holder shall so request in writing, the Company shall include in such Shelf Take-Down all
or any part of the Registrable Securities such Participating Holder requests to be included, subject to Section 3.6(a)(ii), it being understood the Company shall not be responsible for any underwriting discounts or commissions in
connection with any Shelf Take Down. 
 3.2 Piggyback Registrations. If the Company determines to prepare and file with
the SEC a Registration Statement relating to an offering for its own account or the account of others of any of its equity securities at any time prior to August 8, 2018 or until such earlier date that no Registrable Securities are outstanding,
other than on Form S-4 or Form S-8 (each as promulgated under the Securities Act) or their then equivalents relating to equity securities to be issued solely in connection with any acquisition of any entity or business or equity securities issuable
in connection with stock option or other employee benefit plans, then the Company shall send to each Holder written notice of such determination and, if within 15 days after the date of such notice, any such Holder shall so request in writing, the
Company shall include in such Registration Statement all or any part of the Registrable Securities such Holder requests to be registered, subject to Section 3.6(b)(ii). 

3.3 Expenses. All expenses incident to the Company’s performance of or compliance with this Agreement shall be paid by the
Company, other than underwriting discounts or commissions deducted from the proceeds in respect of any Registrable Securities, including (i) all registration and filing fees, and any other fees and expenses associated with filings required to
be made with the SEC, FINRA or any other regulatory authority and, if applicable, the fees and expenses of any “qualified independent underwriter” as such term is defined in NASD Rule 2720 (or any successor provision) and of its counsel,
(ii) all fees and expenses in connection with compliance with any securities or “Blue Sky” laws (including fees 

  
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and disbursements of counsel for the underwriters in connection with “Blue Sky” qualifications of the Registrable Securities), (iii) all printing, duplicating, word processing,
messenger, telephone, facsimile and delivery expenses (including expenses of printing certificates for the Registrable Securities in a form eligible for deposit with The Depository Trust Company and of printing Prospectuses and Free Writing
Prospectuses), (iv) all fees and disbursements of counsel for the Company and of all independent certified public accountants of the Company (including the expenses of any special audit and cold comfort letters required by or incident to such
performance), (v) Securities Act liability insurance or similar insurance if the Company so desires or the underwriters so require in accordance with then-customary underwriting practice, (vi) all fees and expenses incurred in connection
with the listing of Registrable Securities on any securities exchange or quotation of the Registrable Securities on any inter-dealer quotation system, (vii) all reasonable fees and disbursements of one legal counsel for the Participating
Holders, as selected by the Principal Purchasers, (viii) any reasonable fees and disbursements of underwriters customarily paid by issuers or sellers of securities, (ix) all fees and expenses of any special experts or other Persons
retained by the Company in connection with any registration, (x) all of the Company’s internal expenses (including all salaries and expenses of its officers and employees performing legal or accounting duties), (xi) all expenses
related to the “road-show” for any underwritten offering, including all travel, meals and lodging and (xii) any other fees and disbursements customarily paid by the issuers of securities. All such expenses are referred to herein as
“Registration Expenses.” The Company shall not be required to pay any underwriting discounts and commissions and transfer taxes, if any, attributable to the sale of Registrable Securities. 

3.4 Company Obligations. The Company will use reasonable best efforts to effect the registration of the Registrable Securities in
accordance with the terms hereof, and pursuant thereto the Company will, as expeditiously as possible: 
 (a) prepare the
required Registration Statement including all exhibits and financial statements required under the Securities Act to be filed therewith, and before filing a Registration Statement, Prospectus or any Free Writing Prospectus, or any amendments or
supplements thereto, (x) furnish to the underwriters, if any, and the Participating Holders, if any, copies of all documents prepared to be filed, which documents shall be subject to the review of such underwriters and the Participating Holders
and their respective counsel and (y) except in the case of a registration under Section 3.2, not file any Registration Statement or Prospectus or amendments or supplements thereto to which any Participating Holders or the
underwriters, if any, shall reasonably object; 
 (b) as promptly as practicable file with the SEC a Registration Statement
relating to the Registrable Securities including all exhibits and financial statements required by the SEC to be filed therewith, and use its reasonable best efforts to cause such Registration Statement to become effective under the Securities Act;

 (c) prepare and file with the SEC such pre- and post-effective amendments to such Registration Statement, supplements to the
Prospectus and such amendments or supplements to any Free Writing Prospectus as may be (y) reasonably requested by any Participating Holder or (z) necessary to keep such Registration effective for the period of time required by this
Agreement, and comply with provisions of the applicable securities laws 

  
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with respect to the sale or other disposition of all securities covered by such Registration Statement during such period in accordance with the intended method or methods of disposition by the
sellers thereof set forth in such Registration Statement; 
 (d) promptly notify the Participating Holders and the managing
underwriter or underwriters, if any, and (if requested) confirm such advice in writing and provide copies of the relevant documents, as soon as reasonably practicable after notice thereof is received by the Company (A) when the applicable
Registration Statement or any amendment thereto has been filed or becomes effective, and when the applicable Prospectus or Free Writing Prospectus or any amendment or supplement thereto has been filed, (B) of any written comments by the SEC or
any request by the SEC for amendments or supplements to such Registration Statement, Prospectus or Free Writing Prospectus or for additional information, (C) of the issuance by the SEC of any stop order suspending the effectiveness of such
Registration Statement or any order by the SEC preventing or suspending the use of any preliminary or final Prospectus or any Free Writing Prospectus or the initiation or threatening of any proceedings for such purposes, (D) if, at any time,
the representations and warranties of the Company in any applicable underwriting agreement cease to be true and correct in all material respects, (E) of the receipt by the Company of any notification with respect to the suspension of the
qualification of the Registrable Securities for offering or sale in any jurisdiction and (F) of the receipt by the Company of any notification with respect to the initiation or threatening of any proceeding for the suspension of the
qualification of the Registrable Securities for offering or sale in any jurisdiction; 
 (e) promptly notify the Participating
Holders and the managing underwriter or underwriters, if any, when the Company becomes aware of the happening of any event as a result of which the Registration Statement, the Prospectus included in such Registration Statement (as then in effect) or
any Free Writing Prospectus contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements therein (in the case of such Prospectus, any preliminary Prospectus or any Free Writing Prospectus, in
light of the circumstances under which they were made) not misleading, when any Free Writing Prospectus includes information that may conflict with the information contained in the Registration Statement, or, if for any other reason it shall be
necessary during such time period to amend or supplement such Registration Statement, Prospectus or Free Writing Prospectus in order to comply with the Securities Act and, in either case as promptly as reasonably practicable thereafter, prepare and
file with the SEC and furnish without charge to the Participating Holders and the managing underwriter or underwriters, if any, an amendment or supplement to such Registration Statement, Prospectus or Free Writing Prospectus which shall correct such
misstatement or omission or effect such compliance; 
 (f) promptly incorporate in a Prospectus supplement, Free Writing
Prospectus or post-effective amendment to the applicable Registration Statement such information as the managing underwriter or underwriters and the Participating Holders agree should be included therein relating to the plan of distribution with
respect to such Registrable Securities, and make all required filings of such Prospectus supplement, Free Writing Prospectus or post-effective amendment as soon as reasonably practicable after being notified of the matters to be incorporated in such
Prospectus supplement, Free Writing Prospectus or post-effective amendment; 

  
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 (g) furnish to each Participating Holder and each underwriter, if any, without charge, as
many conformed copies as such Participating Holder or underwriter may reasonably request of the applicable Registration Statement and any amendment or post-effective amendment thereto, including financial statements and schedules, all documents
incorporated therein by reference and all exhibits (including those incorporated by reference); 
 (h) deliver to each
Participating Holder and each underwriter, if any, without charge, as many copies of the applicable Prospectus (including each preliminary Prospectus), any Free Writing Prospectus and any amendment or supplement thereto as such Participating Holder
or underwriter may reasonably request (it being understood that the Company consents to the use of such Prospectus, any Free Writing Prospectus and any amendment or supplement thereto by such Participating Holder and the underwriters, if any, in
connection with the offering and sale of the Registrable Securities thereby) and such other documents as such Participating Holder or underwriter may reasonably request in order to facilitate the disposition of the Registrable Securities by such
Participating Holder or underwriter; 
 (i) on or prior to the date on which the Registration Statement is declared effective,
use its reasonable best efforts to register or qualify, and cooperate with the Participating Holders, the managing underwriter or underwriters, if any, and their respective counsel, in connection with the registration or qualification of such
Registrable Securities for offer and sale under the securities or “Blue Sky” laws of each state and other jurisdiction of the United States as any Participating Holder or managing underwriter or underwriters, if any, or their respective
counsel reasonably request in writing and do any and all other acts or things reasonably necessary or advisable to keep such registration or qualification in effect for such period as required by this Agreement, provided that the Company
shall not be required to qualify generally to do business in any jurisdiction where it is not then so qualified or to take any action which would subject it to taxation or general service of process in any such jurisdiction where it is not then so
subject; 
 (j) cooperate with the Participating Holders and the managing underwriter or underwriters, if any, to facilitate
the timely preparation and delivery of certificates representing Registrable Securities to be sold and not bearing any restrictive legends, and enable such Registrable Securities to be in such denominations and registered in such names as the
managing underwriters may request at least two (2) Business Days prior to any sale of Registrable Securities to the underwriters; 
 (k) use its reasonable best efforts to cause the Registrable Securities covered by the Registration Statement to be registered with or approved by such other governmental agencies or authorities as may be
necessary to enable the seller or sellers thereof or the underwriter or underwriters, if any, to consummate the disposition of such Registrable Securities; 
 (l) make such representations and warranties to the Participating Holders and the underwriters or agents, if any, in form, substance and scope as are customarily made by issuers in secondary underwritten
public offerings; 

  
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 (m) enter into such customary agreements (including underwriting and indemnification
agreements) and take all such other actions as the Purchasers or the managing underwriter or underwriters, if any, reasonably request in order to expedite or facilitate the registration and disposition of such Registrable Securities; 

(n) obtain for delivery to the Participating Holders and to the underwriter or underwriters, if any, an opinion or opinions from counsel
for the Company dated the effective date of the Registration Statement or, in the event of an underwritten offering, the date of the closing under the underwriting agreement, in customary form, scope and substance, which opinions shall be reasonably
satisfactory to such Participating Holders or underwriters, as the case may be, and their respective counsel; 
 (o) in the
case of an underwritten offering, obtain for delivery to the Company and the managing underwriter or underwriters, with copies to the Participating Holders, a cold comfort letter from the Company’s independent certified public accountants in
customary form and covering such matters of the type customarily covered by cold comfort letters as the managing underwriter or underwriters reasonably request, dated the date of execution of the underwriting agreement and brought down to the date
of the closing under the underwriting agreement; 
 (p) cooperate with each Participating Holder and each underwriter, if any,
participating in the disposition of such Registrable Securities and their respective counsel in connection with any filings required to be made with FINRA or any other securities regulatory authority; 

(q) use its reasonable best efforts to comply with all applicable securities laws and make available to its security holders, as soon as
reasonably practicable, an earnings statement satisfying the provisions of Section 11(a) of the Securities Act and the rules and regulations promulgated thereunder; 
 (r) provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by the applicable Registration Statement from and after a date not later than the effective
date of such Registration Statement; 
 (s) use its reasonable best efforts to cause all Registrable Securities covered by the
Registration Statement to be listed on each securities exchange on which any of the Common Stock is then listed or quoted and on each inter-dealer quotation system on which any of the Common Stock is then quoted; 

(t) the Company shall make available, during normal business hours, for inspection and review by the Purchasers, advisors to and
representatives of the Purchasers (who may or may not be affiliated with the Purchasers and who are reasonably acceptable to the Company), all financial and other records, all SEC Reports (as defined in the Purchase Agreement) and other filings with
the SEC, and all other corporate documents and properties of the Company as may be reasonably necessary for the purpose of such review, and cause the Company’s officers, directors and employees, within a reasonable time period, to supply all
such information reasonably requested by the Purchasers or any such representative, advisor or 

  
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underwriter in connection with such Registration Statement (including, without limitation, in response to all questions and other inquiries reasonably made or submitted by any of them), prior to
and from time to time after the filing and effectiveness of the Registration Statement for the sole purpose of enabling the Purchasers and such representatives, advisors and underwriters and their respective accountants and attorneys to conduct
initial and ongoing due diligence with respect to the Company and the accuracy of such Registration Statement; and 
 (u) with
a view to making available to the Purchasers the benefits of Rule 144 (or its successor rule) and any other rule or regulation of the SEC that may at any time permit the Purchasers to sell shares of Common Stock to the public without registration,
the Company covenants and agrees to: (i) make and keep public information available, as those terms are understood and defined in Rule 144, until the earlier of (A) the date as all of the Registrable Securities may be sold without
restriction by the holders thereof pursuant to Rule 144 or any other rule of similar effect or (B) such date as all of the Registrable Securities shall have been resold; (ii) file with the SEC in a timely manner all reports and other
documents required of the Company under the Exchange Act; and (iii) furnish to each Purchaser upon request, as long as such Purchaser owns any Registrable Securities, (A) a written statement by the Company that it has complied with the
reporting requirements of the Exchange Act, (B) a copy of the Company’s most recent Annual Report on Form 10-K or Quarterly Report on Form 10-Q, and (C) such other information as may be reasonably requested in order to avail such
Purchaser of any rule or regulation of the SEC that permits the selling of any such Registrable Securities without registration. 
 3.5 Obligations of the Purchasers. 
 (a) Each Purchaser shall furnish in
writing to the Company such information regarding itself, the Registrable Securities held by it and the intended method of disposition of the Registrable Securities held by it, as shall be reasonably required to effect the registration of such
Registrable Securities and shall execute such documents in connection with such registration as the Company may reasonably request. At least five (5) Business Days prior to the first anticipated filing date of any Registration Statement, the
Company shall notify each Purchaser of the information the Company requires from such Purchaser if such Purchaser elects to have any of its Registrable Securities included in the Registration Statement. A Purchaser shall provide such information to
the Company at least two (2) Business Days prior to the first anticipated filing date of such Registration Statement if such Purchaser elects to have any of its Registrable Securities included in the Registration Statement. 

(b) Each Purchaser, by its acceptance of the Registrable Securities agrees to cooperate with the Company as reasonably requested by the
Company in connection with the preparation and filing of a Registration Statement hereunder, unless such Purchaser has notified the Company in writing of its election to exclude all of its Registrable Securities from such Registration Statement.

 (c) Each Purchaser agrees that, upon receipt of any notice from the Company of either (i) the commencement of an
Allowed Delay pursuant to Section 3.1(b)(ii) the happening of an event pursuant to Section 3.4(d) and Section 3.4(e) hereof, such Purchaser will immediately discontinue disposition of Registrable Securities
pursuant to the Registration Statement covering such Registrable Securities, until the Purchaser is advised by the Company that such dispositions may again be made. 

  
 12 

 3.6 Underwriting. 

(a) Shelf Registrations. 
 (i) If the Initiating Shelf Take-Down Holder so requests, an offering of Registrable Securities shall be in the form of an underwritten offering, and such Initiating Shelf Take-Down Holder shall have the
right to select the managing underwriter or underwriters to administer the offering. In the case of an underwritten offering under Section 3.1, the price, underwriting discount and other financial terms for the Registrable Securities
shall be determined by the Initiating Shelf Take-Down Holder. 
 (ii) If the managing underwriter or underwriters of a proposed
underwritten offering of the Registrable Securities included in a Shelf Take-Down advise the Board in writing that, in its or their opinion, the number of securities requested to be included in such Shelf Take-Down exceeds the number which can be
sold in such offering without being likely to have a significant adverse effect on the price, timing or distribution of the securities offered or the market for the securities offered, the securities to be included in such Shelf Take-Down
(i) first, shall be allocated pro rata among the Participating Holders that have requested to participate in such Shelf Take-Down based on the relative number of Registrable Securities requested by each Participating Holder to be
included in such Shelf Take-Down and (ii) second, and only if all the securities referred to in clause (i) have been included in such Shelf Take-Down, the number of securities that the Company proposes to include in such Shelf
Take-Down that, in the opinion of the managing underwriter or underwriters, can be sold without having such adverse effect. 

(iii) If requested by the underwriters for any underwritten offering requested by an Initiating Shelf Take-Down Holder under
Section 3.1, the Company shall enter into an underwriting agreement with such underwriters for such offering, such agreement to be reasonably satisfactory in substance and form to the Company, the Initiating Shelf Take-Down Holder and
the underwriters, and to contain such representations and warranties by the Company and such other terms as are generally prevailing in agreements of that type, including customary indemnities. 

(b) Piggyback Registrations. 
 (i) If the Company proposes to register any of its securities under the Securities Act as contemplated by Section 3.2 and such securities are to be distributed in an underwritten offering
through one or more underwriters, the Company shall, if requested by any Holders pursuant to Section 3.2, use its reasonable best efforts to arrange for such underwriters to include on the same terms and conditions that apply to the
other sellers in such registration all the Registrable Securities to be offered and sold by such Holders among the securities of the Company to be distributed by such underwriters in such registration. 

(ii) If the managing underwriter or underwriters of any proposed underwritten offering including Registrable Securities pursuant to
Section 3.2 informs 

  
 13 

 
the Company and each Participating Holder that, in its or their opinion, the number of securities which the Participating Holders intend to include in such offering exceeds the number which can
be sold in such offering without being likely to have a significant adverse effect on the price, timing or distribution of the securities offered or the market for the securities offered, then the securities to be included in such registration shall
be (i) first, 100% of the securities that the Company and (ii) second, and only if all the securities referred to in clause (i) have been included, the number of Registrable Securities that, in the opinion of such
managing underwriter or underwriters, can be sold without having such adverse effect in such registration, which such number shall be allocated pro rata among the Participating Holders that have requested to participate in such registration
based on the relative number of Registrable Securities requested by each Participating Holder to be included in such underwritten offering. 
 (c) Participation in Underwritten Registrations. Subject to the provisions of Section 3.6(a)(ii) and Section 3.6(b)(ii) above, no Person may participate in any underwritten
offering hereunder unless such Person (i) agrees to sell such Person’s securities on the basis provided in any underwriting arrangements approved by the Persons entitled to approve such arrangements and (ii) completes and executes all
questionnaires, powers of attorney, indemnities, underwriting agreements and other documents required under the terms of such underwriting arrangements and all applicable securities laws. The Participating Holders shall be parties to such
underwriting agreement, which underwriting agreement shall (i) contain such representations and warranties by, and the other agreements on the part of, the Company to and for the benefit of such Participating Holders as are customarily made by
issuers to selling stockholders in secondary underwritten public offerings and (ii) provide that any or all of the conditions precedent to the obligations of such underwriters under such underwriting agreement also shall be conditions precedent
to the obligations of such Participating Holders. Any such Participating Holder shall not be required to make any representations or warranties to or agreements with the Company or the underwriters in connection with such underwriting agreement
other than representations, warranties or agreements regarding such Participating Holder, such Participating Holder’s title to the Registrable Securities, such Participating Holder’s authority to sell the Registrable Securities, such
Participating Holder’s intended method of distribution, absence of liens with respect to the Registrable Securities, enforceability of the applicable underwriting agreement as against such Participating Holder, receipt of all consents and
approvals with respect to the entry into such underwriting agreement and the sale of such Registrable Securities and any other representations required to be made by such Participating Holder under applicable law, rule or regulation, and the
aggregate amount of the liability of such Participating Holder in connection with such underwriting agreement shall not exceed such Participating Holder’s net proceeds from such underwritten offering. 

(d) Clear Market. With respect to any underwritten offerings of Registrable Securities by the Holders, the Company agrees not to,
and shall not be obligated to, effect any public sale or distribution, or to file any Registration Statement covering any of its equity securities or any securities convertible into or exchangeable or exercisable for such securities, during the
period not to exceed ten (10) days prior and sixty (60) days following the effective date of such offering (or such lesser period that the managing underwriters in any underwritten offering permit). Notwithstanding the foregoing, the
Company may effect the registration of (A) equity securities and/or options or other rights in respect thereof solely registered on Form S-4 or Form S-8 (or successor form) or (B) shares of equity securities and/or options or other rights
in respect thereof to be offered to directors, employees, consultants, customers, lenders or vendors of the Company or its Subsidiaries or in connection with dividend reinvestment plans. 

  
 14 

 3.7 Indemnification. 

(a) Indemnification by the Company. The Company will indemnify and hold harmless each Purchaser and its officers, directors,
members, employees and agents, successors and assigns, and each other person, if any, who controls such Purchaser within the meaning of the Securities Act, against any losses, claims, damages or liabilities, joint or several, to which they may
become subject under the Securities Act or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of any material
fact contained in any Registration Statement, any preliminary Prospectus or final Prospectus, or any amendment or supplement thereof or any omission or alleged omission to state a material fact required to be stated therein or necessary to make the
statements therein not misleading, in light of the circumstances in which they were made; (ii) any “Blue Sky” application or other document executed by the Company specifically for that purpose or based upon written information
furnished by the Company filed in any state or other jurisdiction in order to qualify any or all of the Registrable Securities under the securities laws thereof (any such application, document or information herein called a “Blue Sky
Application”); (iii) the omission or alleged omission to state in a Blue Sky Application a material fact required to be stated therein or necessary to make the statements therein not misleading, in light of the circumstances in which
they were made; (iv) any violation by the Company or its agents of any rule or regulation promulgated under the Securities Act applicable to the Company or its agents and relating to action or inaction required of the Company in connection with
such registration; or (v) any failure to register or qualify the Registrable Securities included in any such Registration Statement in any state where the Company or its agents has affirmatively undertaken or agreed in writing that the Company
will undertake such registration or qualification on a Purchaser’s behalf and will reimburse such Purchaser, and each such officer, director or member and each such controlling person for any legal or other expenses reasonably incurred by them
in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the Company will not be liable in any such case if and to the extent that any such loss, claim, damage or
liability arises out of or is based upon an untrue statement or alleged untrue statement or omission or alleged omission so made in conformity with information furnished by such Purchaser or any such controlling person in writing specifically for
use in such Registration Statement or Prospectus. 
 (b) Indemnification by the Purchasers. Each Purchaser agrees,
severally but not jointly, to indemnify and hold harmless, to the fullest extent permitted by law, the Company, its directors, officers, employees, stockholders and each person who controls the Company (within the meaning of the Securities Act)
against any losses, claims, damages, liabilities and expense (including reasonable attorney fees) resulting from any untrue statement or alleged untrue statement of a material fact or any omission or alleged omission of a material fact required to
be stated in the Registration Statement or Prospectus or preliminary Prospectus or amendment or supplement thereto or necessary to make the statements therein not misleading, in light of the circumstances in which they were made, to the extent, but
only to the extent that 

  
 15 

 
such untrue statement or alleged untrue statement or omission or alleged omission is contained in any information furnished in writing by such Purchaser to the Company specifically for inclusion
in such Registration Statement or Prospectus or amendment or supplement thereto. In no event shall the liability of a Purchaser be greater in amount than the dollar amount of the proceeds (net of all expense paid by such Purchaser in connection with
any claim relating to this Section 3 and the amount of any damages such Purchaser has otherwise been required to pay by reason of such untrue statement or omission) received by such Purchaser upon the sale of the Registrable Securities
included in the Registration Statement giving rise to such indemnification obligation. 
 (c) Conduct of Indemnification
Proceedings. Any Person entitled to indemnification hereunder shall (i) give prompt notice to the indemnifying party of any claim with respect to which it seeks indemnification and (ii) permit such indemnifying party to assume the
defense of such claim with counsel reasonably satisfactory to the indemnified party (provided, however, that such indemnified party shall, at the expense of the indemnifying party, be entitled to counsel of its own choosing to monitor
such defense); provided that, subject to the preceding sentence, any Person entitled to indemnification hereunder shall have the right to employ separate counsel and to participate in the defense of such claim, but the fees and expenses of
such counsel shall be at the expense of such Person unless (a) the indemnifying party has agreed to pay such fees or expenses, or (b) the indemnifying party shall have failed to assume the defense of such claim and employ counsel
reasonably satisfactory to such person or (c) in the reasonable judgment of any such Person, based upon written advice of its counsel, a conflict of interest exists between such person and the indemnifying party with respect to such claims (in
which case, if the Person notifies the indemnifying party in writing that such Person elects to employ separate counsel at the expense of the indemnifying party, the indemnifying party shall not have the right to assume the defense of such claim on
behalf of such Person); and provided, further, that the failure of any indemnified party to give notice as provided herein shall not relieve the indemnifying party of its obligations hereunder, except to the extent that such failure to
give notice shall materially adversely affect the indemnifying party in the defense of any such claim or litigation. It is understood that the indemnifying party shall not, in connection with any proceeding in the same jurisdiction, be liable for
fees or expenses of more than one separate firm of attorneys at any time for all such indemnified parties. No indemnifying party will, except with the consent of the indemnified party, consent to entry of any judgment or enter into any settlement
that does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect of such claim or litigation. 

(d) Contribution. If for any reason the indemnification provided for in the preceding paragraphs (a) and (b) is
unavailable to an indemnified party or insufficient to hold it harmless, other than as expressly specified therein, then the indemnifying party shall contribute to the amount paid or payable by the indemnified party as a result of such loss, claim,
damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnified party and the indemnifying party, as well as any other relevant equitable considerations. No Person guilty of fraudulent misrepresentation
within the meaning of Section 11(f) of the Securities Act shall be entitled to contribution from any Person not guilty of such fraudulent misrepresentation. In no event shall the contribution obligation of a holder of Registrable Securities be
greater in amount than the dollar amount of the proceeds (net of all expenses paid by such holder in connection with any claim relating to this Section 3 and the amount of any damages such holder

  
 16 

 
has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission) received by it upon the sale of the Registrable Securities giving rise to
such contribution obligation. 
 4. Restrictions on Transfer; Subsequent Purchases. Each Purchaser agrees that it will
not, without the prior written consent of the Company, directly or indirectly, (a) offer for sale, sell, contract to sell, lend, grant any option to purchase, make any short sale or otherwise dispose of, or (b) purchase, contract to
purchase, offer to purchase, borrow or otherwise acquire, any securities of the Company, or rights or options to acquire any voting securities of the Company, including derivative securities representing the right to vote or economic benefits of any
such securities, on or prior to the one (1) year anniversary of the date of this Agreement; provided that (i) (w) a Purchaser that is a natural person may acquire Shares from or sell or otherwise transfer Shares to one or more
trusts for the benefit of such Purchaser, such Purchaser’s spouse, lineal descendant of such Purchaser or such Purchaser’s parents, the spouse of any such descendant or a lineal descendant of any such spouse and (x) a Purchaser that
is a Person other than a natural person may acquire Shares from or sell or otherwise transfer Shares to an Affiliate of such Purchaser; provided that in the case of any transfer or distribution pursuant to clause (i), each trustee,
trust, transferee, transferees, donee or donees, as applicable, agrees to be bound in writing by the restrictions set forth in this Section 4, (ii) a Purchaser may exercise Warrants, (iii) a Purchaser that is a director or
employee of the Company may exercise stock options granted pursuant to a Company equity incentive plan, (iv) a Purchaser that is a director or employee of the Company may receive restricted stock units or stock options granted pursuant to a
Company equity incentive plan, and (v) a Purchaser may transfer Shares to the extent necessary to generate such amount of cash needed for the payment of taxes (including estimated taxes) due as a result of the exercise of such stock options or
to pay the exercise price of such stock options. Each Purchaser acknowledges and agrees that any purchase, sale or other transfer or disposition, of any Common Stock or Warrants in violation of this Section 4 will be null and void, and
each Purchaser consents to the entry of stop transfer instructions with the Company’s transfer agent and registrar against the transfer of any Common Stock or Warrants except in compliance with the foregoing restrictions. Notwithstanding the
foregoing, this Section 4 will automatically terminate and be of no further force and effect with respect to any Purchaser upon the earlier of a Change of Control (as long as such Change of Control was not initiated by such Purchaser) or
an Insolvency Event. 
 5. Miscellaneous. 
 5.1 Governing Law; Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of Delaware without regard to the choice of law principles
thereof. Each of the parties hereto irrevocably submits to the exclusive jurisdiction of the state and federal courts located in the State of Delaware for the purpose of any suit, action, proceeding or judgment relating to or arising out of this
Agreement and the transactions contemplated hereby. Service of process in connection with any such suit, action or proceeding may be served on each party hereto anywhere in the world by the same methods as are specified for the giving of notices
under this Agreement. Each of the parties hereto irrevocably consents to the jurisdiction of any such court in any such suit, action or proceeding and to the laying of venue in such court. Each party hereto irrevocably waives any objection to the
laying of venue of any such suit, action or proceeding brought in such courts and irrevocably waives any claim that any such suit, action or proceeding brought in any such court has been brought in an inconvenient forum. 

  
 17 

 5.2 Successors and Assigns. Subject to Section 4, except as otherwise
expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the successor and assigns of the parties hereto (other than the rights of any Holder under Sections 2 or 3 hereof, which shall not be
assignable and shall not inure to the benefit of any successor or assign of a Holder). The Company may not assign its rights or obligations hereunder except with the prior written consent of each Holder. Each Holder may assign their respective
rights hereunder in the manner and to the Persons permitted under the Purchase Agreement, except as specified above. 
 5.3
Entire Agreement; Amendment. This Agreement and the other Transaction Documents constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and thereof. Any previous agreements among the
parties relative to the specific subject matter hereof are superseded by this Agreement. Neither this Agreement nor any provision hereof may be amended, changed, waived, discharged or terminated other than by a written instrument signed by the party
against who enforcement of any such amendment, change, waiver, discharge or termination is sought. 
 5.4 Notices. All
notices and other communications provided for or permitted hereunder shall be made as set forth in Section 7.3 of the Purchase Agreement. 
 5.5 Severability. If any term, provision, covenant or restriction of this Agreement is held by a court of competent jurisdiction to be invalid, illegal, void or unenforceable, the remainder of the
terms, provisions, covenants and restrictions set forth herein shall remain in full force and effect and shall in no way be affected, impaired or invalidated, and the parties hereto shall use their commercially reasonable efforts to find and employ
an alternative means to achieve the same or substantially the same result as that contemplated by such term, provision, covenant or restriction. It is hereby stipulated and declared to be the intention of the parties that they would have executed
the remaining terms, provisions, covenants and restrictions without including any of such that may be hereafter declared invalid, illegal, void or unenforceable. 
 5.6 Headings. The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof. 

5.7 Counterparts. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered
one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to each other party, it being understood that the parties need not sign the same counterpart. In the event that any signature is
delivered by facsimile transmission or by e-mail delivery of a “.pdf” format data file, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same force
and effect as if such facsimile or “.pdf” signature page were an original thereof. 

  
 18 

 5.8 Delays or Omissions. It is agreed that no delay or omission to exercise any
right, power or remedy accruing to any party upon any breach or default of any other party under this Agreement shall impair any such right, power or remedy, nor shall it be construed to be a waiver of any such breach or default, or any acquiescence
therein, or of any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. It is further agreed that any waiver,
permit, consent or approval of any kind or character of any breach or default under this Agreement, or any waiver of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth
in writing, and that all remedies, either under this Agreement, by law or otherwise, shall be cumulative and not alternative. 

5.9 Consents. Any permission, consent, or approval of any kind or character under this Agreement shall be in writing and shall be
effective only to the extent specifically set forth in such writing. 
 5.10 SPECIFIC PERFORMANCE. THE PARTIES HERETO
AGREE THAT IRREPARABLE DAMAGE WOULD OCCUR IN THE EVENT THAT ANY OF THE PROVISIONS OF THIS AGREEMENT WERE NOT PERFORMED IN ACCORDANCE WITH ITS SPECIFIC INTENT OR WERE OTHERWISE BREACHED. IT IS ACCORDINGLY AGREED THAT THE PARTIES SHALL BE ENTITLED TO
AN INJUNCTION OR INJUNCTIONS, WITHOUT BOND, TO PREVENT OR CURE BREACHES OF THE PROVISIONS OF THIS AGREEMENT AND TO ENFORCE SPECIFICALLY THE TERMS AND PROVISIONS HEREOF, THIS BEING IN ADDITION TO ANY OTHER REMEDY TO WHICH THEY MAY BE ENTITLED BY LAW
OR EQUITY, AND ANY PARTY SUED FOR BREACH OF THIS AGREEMENT EXPRESSLY WAIVES ANY DEFENSE THAT A REMEDY IN DAMAGES WOULD BE ADEQUATE. 
 5.11 Construction of Agreement. No provision of this Agreement shall be construed against either party as the drafter thereof. 

5.12 Section References. Unless otherwise stated, any reference contained herein to a Section or subsection refers to the
provisions of this Agreement. 
 5.13 Variations of Pronouns. All pronouns and all variations thereof shall be deemed to
refer to the masculine, feminine, or neuter, singular or plural, as the context in which they are used may require. 

[Remainder of Page Intentionally Left Blank] 

  
 19 

 IN WITNESS WHEREOF, the parties have caused this Investor Rights Agreement to be duly
executed and delivered by their proper and duly authorized officers as of the day and year first written above. 
  

			
	HANSEN MEDICAL, INC.
		
	By:	 	/s/ Bruce Barclay
	Name: Bruce Barclay
	Title: President and Chief Executive Officer

 [Signature Page to Investor Rights Agreement] 

 
			
	SCHULER FAMILY FOUNDATION
		
	By:	 	/s/ Jack W. Schuler
	Name: Jack W. Schuler
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	TINO HANS SCHULER TRUST
		
	By:	 	/s/ H. George Schuler
	Name: H. George Schuler
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	TANYA EVE SCHULER TRUST
		
	By:	 	/s/ H. George Schuler
	Name: H. George Schuler
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	THERESE HEIDI SCHULER TRUST
		
	By:	 	/s/ H. George Schuler
	Name: H. George Schuler
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	ORACLE PARTNERS, LP
		
	By:	 	/s/ Larry N. Feinberg
	Name: Larry N. Feinberg
	Title: Managing Member of General Partner

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	ORACLE TEN FUND MASTER, LP
		
	By:	 	/s/ Larry N. Feinberg
	Name: Larry N. Feinberg
	Title: Managing Member of General Partner

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	ORACLE INSITUTIONAL PARTNERS, LP
		
	By:	 	/s/ Larry N. Feinberg
	Name: Larry N. Feinberg
	Title: Managing Member of General Partner

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	FEINBERG FAMILY TRUST
		
	By:	 	/s/ Adam Usdan
	Name: Adam Usdan
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	MATTHEW STROBECK
	
	/s/ Matthew Strobeck
	Name: Matthew Strobeck

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	VAUGHN BRYSON
	
	/s/ Vaughn Bryson
	Name: Vaughn Bryson

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	GARO ARMEN
	
	/s/ Garo Armen
	Name: Garo Armen

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	MICHAEL GORDON
	
	/s/ Michael Gordon
	Name: Michael Gordon

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	 NOOWOSH, L.P.
 by
O’stein Partners, LLC, General Partner
 by Weinstein Partners L.P., Manager

		
	By:	 	/s/ Will K. Weinstein
	Name: Will K. Weinstein
	Title: General Partner

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	MARJORIE L. BOWEN
	
	/s/ Marjorie L. Bowen
	Name: Marjorie L. Bowen

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	NADIM YARED
	
	/s/ Nadim Yared
	Name: Nadim Yared

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	 WILLIAM R. ROHN AND MARY JANE ROHN
 FAMILY TRUST DATED AUGUST 12, 1999
 P.O. BOX 67367

RANCHO SANTA FE, CA 92067

		
	By:	 	/s/ William R. Rohn
	Name: William R. Rohn
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	KEVIN HYKES
	
	/s/ Kevin Hykes
	Name: Kevin Hykes

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	STEPHEN L. NEWMAN, M.D.
	
	/s/ Stephen L. Newman, M.D.
	Name: Stephen L. Newman, M.D.

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	CATHERINE H. KENNEDY REVOCABLE TRUST
		
	By:	 	/s/ Catherine H. Kennedy
	Name: Catherine H. Kennedy
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	CHRISTINE K. BROWNER REVOCABLE TRUST
		
	By:	 	/s/ Christine K. Browner
	Name: Christine K. Browner
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	LAWRENCE T. KENNEDY, JR. REVOCABLE TRUST
		
	By:	 	/s/ Lawrence T. Kennedy, Jr.
	Name: Lawrence T. Kennedy, Jr.
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	CENTRAL PARK ASSOCIATES, LLC
		
	By:	 	/s/ Lawrence T. Kennedy, Jr.
	Name: Lawrence T. Kennedy, Jr.
	Title: Managing Member

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	MARTHA K. LORD REVOCABLE TRUST
		
	By:	 	/s/ Martha K. Lord
	Name: Martha K. Lord
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	PETER M. KENNEDY REVOCABLE TRUST
		
	By:	 	/s/ Peter M. Kennedy
	Name: Peter M. Kennedy
	Title: Trustee

  
 [Signature
Page to Investor Rights Agreement] 

 
			
	 WW ASSOCIATES, LP

by WW Management, Inc., General Partner

		
	By:	 	/s/ Lawrence T. Kennedy, Jr.
	Name: Lawrence T. Kennedy, Jr.
	Title: Assistant Treasurer

  
 [Signature
Page to Investor Rights Agreement]EX-4.1

 Exhibit 4.1 
 

 
  
 COLUMBIA 
 LABORATORIES, INC. 

NUMBER 
 SHARES 
 CL 

COLUMBIA 
 LABORATORIES, INC. 
 INCORPORATED UNDER THE LAWS

 SEE REVERSE FOR 
 OF THE STATE OF DELAWARE 
 CERTAIN DEFINITIONS

 THIS IS TO CERTIFY THAT 
 CUSIP 197779 20 0 
 IS THE OWNER OF 

FULLY PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK OF THE PAR VALUE OF $.01 PER SHARE OF 

COLUMBIA LABORATORIES, INC. 
 (hereinafter called the “Corporation”) transferable on the books of the Corporation by said owner in person or by duly authorized attorney, upon surrender of this certificate
properly endorsed. This certificate is not valid unless countersigned by the Transfer Agent. 
 Witness, the
facsimile seal of the Corporation and the facsimile signatures of its duly authorized officers. 
 Dated:

 SECRETARY 
 COLUMBIA LABORATORIES, INC. 
 CORPORATE SEAL 1986
DELAWARE 
 SECURITY-COLUMBIAN UNITED STATES BANKNOTE CORPORATION 

PRESIDENT 
 COUNTERSIGNED AND REGISTERED: 
 AMERICAN STOCK
TRANSFER & TRUST COMPANY 
 (New York, N.Y.) 

By: 
 TRANSFER AGENT 
 AND REGISTRAR 

AUTHORIZED SIGNATURE 

 

 
  
 The
Corporation is authorized to issue more than one class of stock. The Corporation will furnish without charge to each stockholder who so requests a statement of the powers, designations, preferences and relative, participating, optional or other
special rights of each class of stock or series thereof and the qualifications, limitations or restrictions of such preferences and/or rights. 
 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or
regulations: 
 TEN COM—as tenants in common 

TEN ENT —as tenants by the entireties 
 JT TEN —as joint tenants with right of 

survivorship and not as tenants 
 in common 
 Additional abbreviations may also be
used though not in the above list. 
 UNIF GIFT MIN ACT— Custodian 

(Cust) (Minor) 
 under Uniform Gifts to Minors 
 Act 

(State) 
 For value received, hereby sell, assign and transfer unto 
 PLEASE INSERT SOCIAL SECURITY OR OTHER 

IDENTIFYING NUMBER OF ASSIGNEE 
 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE) 
 shares of the capital stock represented by the within Certificate, and do hereby irrevocably constitute and appoint 
 Attorney to transfer the said stock on the books of the within named Corporation with full power of substitution in the premises. 

Dated 
 NOTICE: 
 THE SIGNATURE TO THIS ASSIGNMENT MUST
CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATEVER. 
 THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE
GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15. 
 SIGNATURE(S) GUARANTEED: 

KEEP THIS CERTIFICATE IN A SAFE PLACE. IF IT IS LOST, STOLEN, MUTILATED OR DESTROYED, THE CORPORATION WILL REQUIRE A BOND
OF INDEMNITY AS A CONDITION TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE. 
 This certificate also evidences and
entitles the holder hereof to the same number of Rights (subject to adjustment) as the number of shares of Common Stock represented by this certificate, such Rights being on the terms provided under Amendment No.2 to the Amended and Restated Rights
Agreement by and between Columbia Laboratories, Inc. and American Stock Transfer & Trust Company, LLC (the “Rights Agent”), dated as of March 15, 2013, as it may be amended from time to time (the “Agreement”), the terms of
which are incorporated herein by reference and a copy of which is on file at the principal executive offices of Columbia Laboratories, Inc. Under certain circumstances, as set forth in the Agreement, such Rights shall be evidenced by separate
certificates and shall no longer be evidenced by this certificate. Columbia Laboratories, Inc. shall mail to the registered holder of this certificate a copy of the Agreement without charge within five days after receipt of a written request
therefor. As provided in Section 7(e) of the Agreement, Rights issued to or Beneficially Owned by Acquiring Persons or their Affiliates or Associates (as such terms are defined in the Agreement) or any subsequent holder of such Rights shall be
null and void and may not be exercised by or transferred to any Person.

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