Document:

EX-4.2

 Exhibit 4.2 

EXECUTION VERSION 
  

 
 THERMO FISHER SCIENTIFIC INC. 

as Issuer 
 AND 

THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., 

as Trustee 
 AND 

THE BANK OF NEW YORK MELLON, LONDON BRANCH, 

as London Paying Agent 
 TENTH
SUPPLEMENTAL INDENTURE 
 Dated as of November 24, 2015 

€425,000,000 of 1.500% Senior Notes due 2020 
  

 

 THIS TENTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”) is
dated as of November 24, 2015 among THERMO FISHER SCIENTIFIC INC., a Delaware corporation (the “Company”), THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association, as trustee (the
“Trustee”), and THE BANK OF NEW YORK MELLON, LONDON BRANCH, as paying agent (the “London Paying Agent”) . 

RECITALS 
 WHEREAS, the
Company and the Trustee executed and delivered an Indenture, dated as of November 20, 2009 (the “Base Indenture” and, as supplemented by this Supplemental Indenture, the “Indenture”), to provide for the
issuance by the Company from time to time of unsubordinated debt securities evidencing its unsecured indebtedness. 
 WHEREAS, the
Company has authorized the issuance of €425,000,000 aggregate principal amount of 1.500% Senior Notes due 2020 (the “Notes”). 

WHEREAS, the entry into this Supplemental Indenture by the parties hereto is in all respects authorized by the provisions of the Base
Indenture. 
 WHEREAS, the Company desires to enter into this Supplemental Indenture pursuant to Section 9.01 of the Base Indenture to
establish the terms of the Notes in accordance with Section 2.01 of the Base Indenture and to establish the form of the Notes in accordance with Sections 2.01(a)(10) and 2.02 of the Base Indenture. 

WHEREAS, all things necessary to make this Supplemental Indenture a valid and legally binding agreement according to its terms have been done.

 NOW, THEREFORE, for and in consideration of the foregoing premises, the Company, the Trustee and the London Paying Agent, mutually
covenant and agree for the equal and proportionate benefit of the respective holders from time to time of the Notes as follows: 
 ARTICLE I

  

	Section 1.1	Defined Terms. 

 As used herein, the following defined terms shall have the following
meanings with respect to the Notes and this Supplemental Indenture only: 
 “Additional Amounts” has the meaning set forth
in Section 1.4(2).  
 “Below Investment Grade Rating Event” means the Notes are downgraded below Investment
Grade Rating by any two of the Rating Agencies on any date during the period (the “Trigger Period”) commencing 60 days prior to the first public announcement by the Company of the occurrence of a Change of Control (or pending Change
of Control) and ending 60 days following consummation of such Change of Control (which Trigger Period shall be extended so long as the rating of the Notes is under publicly announced consideration for

  
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possible downgrade by at least two of such Rating Agencies on such 60th day, such extension to last with respect to each such Rating Agency until the date on which such Rating Agency considering
such possible downgrade either (x) rates the Notes below Investment Grade or (y) publicly announces that it is no longer considering the Notes for possible downgrade, provided that no such extension will occur if on such 60th day the Notes
are rated Investment Grade by at least two of such Rating Agencies in question and are not subject to review for possible downgrade by such Rating Agencies). 

“Business Day” means any day, other than a Saturday or Sunday, (1) which is not a day on which banking
institutions in The City of New York or London are authorized or required by law, regulation or executive order to close and (2) on which the Trans-European Automated Real-Time Gross Settlement Express Transfer system (the TARGET2 system), or
any successor thereto, is open. 
 “Change of Control” means the occurrence of any of the following:
(1) direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its
subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its direct or indirect wholly-owned subsidiaries; (2) the consummation of any
transaction (including, without limitation, any merger or consolidation) as a result of which any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) becomes the “beneficial owner” (as defined in Rules
13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed,
measured by voting power rather than number of shares; (3) the Company consolidates with, or merges with or into, any “person” or “group” (as that term is used in Section 13(d)(3) of the Exchange Act), or any
“person” or “group” consolidates with, or merges with or into, the Company, in any such event pursuant to a transaction in which any of the Company’s Voting Stock or the Voting Stock of such other person is converted into or
exchanged for cash, securities or other property, other than any such transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of
the Voting Stock of the surviving person or any direct or indirect parent company of the surviving person immediately after giving effect to such transaction; (4) the first day on which a majority of the members of the Company’s board of
directors are not Continuing Directors; or (5) the adoption of a plan relating to the Company’s liquidation or dissolution. Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control if (a) the
Company becomes a direct or indirect wholly owned subsidiary of a holding company (which shall include a parent company) and (b)(i) the holders of the Voting Stock of such holding company immediately following that transaction are substantially the
same as the holders of our Voting Stock immediately prior to that transaction or (ii) no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) (other than a holding company satisfying the requirements of this
sentence) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the voting power of the Voting Stock of such holding company immediately following such
transaction. 

  
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 “Change of Control Triggering Event” means the occurrence of both a
Change of Control and a Below Investment Grade Rating Event. 
 “Common Depositary” means The Bank of New
York Mellon, London Branch, as common depositary for the Depositary.  
 “Comparable Bond Rate” means, for
any Optional Redemption Date, the rate per annum equal to the annual equivalent yield to maturity or interpolated yield to maturity (on a day count basis), computed as of the third Business Day immediately preceding that Optional Redemption Date, of
the Comparable Government Issue, assuming a price for the Comparable Government Issue (expressed as a percentage of its principal amount) equal to the Comparable Price for that Optional Redemption Date. 

“Comparable Government Issue” means the euro-denominated security issued by the German government selected by an
Independent Investment Banker as having an actual or interpolated maturity comparable to the remaining term of the Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing
new issues of corporate debt securities of comparable maturity to the remaining term of the Notes to be redeemed. 

“Comparable Price” means, with respect to any Optional Redemption Date, (a) the average of the Reference Dealer
Quotations for such Optional Redemption Date, after excluding the highest and lowest of the Reference Dealer Quotations, (b) if the Company obtains fewer than four Reference Dealer Quotations, the arithmetic average of those quotations or
(c) if the Company obtains only one Reference Dealer Quotation, such Reference Dealer Quotation. 
 “Continuing
Directors” means, as of any date of determination, any member of the Board of Directors of the Company who (1) was a member of the Board of Directors of the Company on the date of the issuance of the Notes; or (2) was nominated
for election or elected to the Board of Directors of the Company with the approval of a majority of the Continuing Directors who were members of such Board of Directors of the Company at the time of such nomination or election (either by specific
vote or by approval of the Company’s proxy statement in which such member was named as a nominee for election as a director, without objection to such nomination). 

“Depositary” means each of Clearstream Banking, société anonyme, Luxembourg and Euroclear Bank S.A./N.V.
as operator of the Euroclear System. 
 “euro” or “€” means the single currency introduced at
the third stage of the European Monetary Union pursuant to the Treaty establishing the European Community, as amended. 

“Fitch” means Fitch Ratings, Inc. 

“ICMA”means the International Capital Markets Association. 

  
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 “Independent Investment Banker” means each Reference Dealer appointed by
the Company as Independent Investment Banker (initially, Deutsche Bank AG, London Branch and HSBC Bank plc). 

“Internal Revenue Code” means the U.S. Internal Revenue Code of 1986, as amended. 

“Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under a
successor rating category of Moody’s) or a rating by S&P equal to or higher than BBB- (or the equivalent under any successor rating category of S&P) or a rating by Fitch equal to or higher than BBB- (or the equivalent under any
successor rating category of Fitch). 
 “Moody’s” means Moody’s Investors Service, Inc. 

“Optional Redemption Date” when used with respect to any Note to be redeemed at the Company’s option, means the
date fixed for such redemption by or pursuant to Section 1.3 of this Supplemental Indenture. 
 “Optional
Redemption Price” when used with respect to any Note to be redeemed at the Company’s option, means the price, calculated by the Company, at which it is to be redeemed pursuant to Section 1.3 of this Supplemental Indenture.

 “Primary Bond Dealer” means a broker or dealer of, and/or market maker in German government bonds. 

“Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any of Moody’s, S&P or
Fitch ceases to rate the Notes or fails to make a rating of the Notes publicly available for any reason, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) under the Exchange Act, selected
by the Company (as certified by a resolution of the Board of Directors) as a replacement agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be. 

“Reference Dealer” means each of (i) Deutsche Bank AG, London Branch and HSBC Bank plc and their respective
affiliates or successors and (ii) three other nationally recognized investment banking firms (or their respective affiliates) that are Primary Bond Dealers that the Company selects in connection with the particular redemption, and their
respective successors, provided that if at any time any of the above is not a Primary Bond Dealer, the Company will substitute that entity with another nationally recognized investment banking firm that the Company selects that is a Primary Bond
Dealer. 
 “Reference Dealer Quotations” means, with respect to each Reference Dealer and any Optional
Redemption Date, the arithmetic average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Government Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the
Independent Investment Banker by such Reference Dealer at 11:00 a.m., London time, on the third Business Day preceding such Optional Redemption Date. 

  
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 “Remaining Scheduled Payments” means, with respect to each Note to be
redeemed, the remaining scheduled payments of the principal thereof and interest thereon that would be due after the related Optional Redemption Date for such redemption; provided, however, that, if such Optional Redemption Date is not an interest
payment date with respect to such Note, the amount of the next succeeding scheduled interest payment thereon will be reduced by the amount of interest accrued thereon to such Optional Redemption Date. 

“S&P” means Standard & Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and
any successor to its rating agency business. 
 “Specified Office of the London Paying Agent” means,
initially, the London Branch of The Bank of New York Mellon, located at One Canada Square, London E14 5AL, England.  

“Treasury Regulations” means the U.S. Treasury Regulations promulgated under the Internal Revenue Code. 

“United States person” means any individual who is a citizen or resident of the United States for U.S. federal income
tax purposes, a corporation, partnership or other entity created or organized in or under the laws of the United States, any state of the United States or the District of Columbia (other than a partnership that is not treated as a United States
person under any applicable Treasury Regulations), or any estate or trust the income of which is subject to United States federal income taxation regardless of its source.  

“United States” means the United States of America, the states of the United States, and the District of Columbia.

 “Voting Stock” means with respect to any specified person (as that term is used in Section 13(d)(3) of
the Exchange Act) Capital Stock of any class or kind the holders of which are ordinarily, in the absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to
vote has been suspended by the happening of such a contingency. 
  

	Section 1.2	Terms of the Notes. 

 The following terms relate to the Notes: 

(1) The Notes shall constitute a separate series of Notes having the title “1.500% Senior Notes due 2020”. 

(2) The aggregate principal amount of the Notes that may be initially authenticated and delivered under the Indenture (the
“Initial Notes”) shall be €425,000,000. The Company may from time to time, without the consent of the Holders of Notes, issue additional Notes (the “Additional Notes”) having the same terms (except for the
issue date, offering price and, if applicable, the first interest payment date) as the Initial Notes. Any Additional Notes and the Initial Notes shall together constitute a single series under the Indenture and all references to the Notes shall
include both the Initial Notes and the Additional Notes, unless the context otherwise requires. The aggregate principal amount of the Notes shall be unlimited. The entire Outstanding  

  
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principal amount of the Notes shall be payable on December 1, 2020. The principal of each Note payable at maturity or upon earlier redemption shall be paid against presentation and
surrender of such Note at the office or agency maintained for such purposes in London, initially, the Specified Office of the London Paying Agent. 

(3) The rate at which the Notes shall bear interest shall be 1.500% per annum. The date from which interest shall accrue on the
Notes shall be the most recent Interest Payment Date to which interest has been paid or provided for or, if no interest has been paid, from November 24, 2015. The Interest Payment Dates for the Notes shall be December 1 of each year,
beginning December 1, 2016, until the principal is paid or made available for payment. Interest shall be payable in arrears on each Interest Payment Date to the holders of record at the close of business on the November 15 prior to each
Interest Payment Date, whether or not a Business Day, as the case may be (each such date being a “regular record date”). Interest on the notes shall be computed on the basis of an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of
ICMA) day count convention. 
 (4) The Notes shall be issuable in whole in the form of one or more registered Global Securities,
without coupons, which shall be deposited with, or on behalf of, the applicable Depositary and shall be registered in the name of the Common Depositary for, and in respect of interests held through, the applicable Depositary. The Notes shall be
substantially in the form attached hereto as Exhibit A, the terms of which are herein incorporated by reference. The Notes shall be issuable in denominations of €100,000 or any integral multiple of €1,000 in excess thereof. 

(5) The Notes may be redeemed at the option of the Company prior to the maturity date, as provided in Section 1.3 hereof. 

(6) The Notes shall not have the benefit of any sinking fund. 

(7) Except as provided herein, the holders of the Notes shall have no special rights in addition to those provided in the Base Indenture upon
the occurrence of any particular events. 
 (8) The Notes shall be general unsecured and unsubordinated obligations of the Company and shall
be ranked equally among themselves. 
 (9) The Notes are not convertible into shares of common stock or other securities of the Company.

 (10) The covenants set forth in Section 1.4 hereof shall be applicable to the Notes. 

(11) The transfer and exchange provisions set forth in Section 2.05 of the Base Indenture shall be applicable to the Notes, except that
the first paragraph of Section 2.05(c) shall be modified with respect to the Notes as follows: 
 A Global Security may not be
transferred except as a whole by the Common Depositary for the Notes to a nominee of such Common Depositary, by a nominee of such Common Depositary to such Common Depositary or to another nominee of such Common Depositary or by such Common
Depositary or any such nominee to a successor Common 

  
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Depositary for the Notes or a nominee of such successor Common Depositary. If at any time the Common Depositary notifies the Company that it is unwilling, unable or no longer qualified to
continue as Common Depositary for the Notes and a successor Common Depositary is not appointed by the Company within 90 days after the Company receives such notice or becomes aware of such condition, the provisions of Section 2.11 of the Base
Indenture shall no longer be applicable to the Notes. In addition, (i) if the Company at any time notifies the Trustee in writing that the Notes shall no longer be represented by a Global Security, the provisions of Section 2.11 of the
Base Indenture shall no longer apply to the Notes and (ii) if the Trustee so requests, upon an Event of Default, the Notes shall no longer be represented by a Global Security and the provisions of Section 2.11 of the Base Indenture shall
no longer apply to the Notes. In any such event the Company shall execute Notes in the form of Definitive Securities in minimum denominations of €100,000 principal amount and integral multiples of €1,000 in excess thereof, and in an
aggregate principal amount equal to the principal amount of the Global Security representing such Notes and, subject to Section 2.05 of the Base Indenture, the Trustee, upon receipt of an Officer’s Certificate evidencing such determination
by the Company, if applicable, shall authenticate and deliver such Definitive Securities in exchange for such Global Security. Upon the exchange of the Global Security of such Definitive Securities, the Global Security shall be canceled by the
Trustee. Such Definitive Securities shall be registered in such names and in such authorized denominations as the Common Depositary, pursuant to instructions from its Participants or indirect participants or otherwise, shall in writing instruct the
Trustee. The Trustee shall deliver the Notes to the Common Depositary for delivery to the Persons in whose names the Notes are so registered. 

(12) All payments of principal of, and interest (including Additional Amounts, if any) and premium (if any) on, the Notes shall be payable in
euro; provided, however, that if, on or after November 13, 2015, euro is unavailable to the Company due to the imposition of exchange controls or other circumstances beyond the Company’s control or if the euro is no longer being used by
the then member states of the European Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or within the international banking community, then all payments in respect of the
Notes shall be made in U.S. dollars until the euro is again available to the Company or so used. In such circumstances, the amount payable on any date in euro shall be converted into U.S. dollars at the rate mandated by the U.S. Federal Reserve
Board as of the close of business on the second Business Day prior to the relevant payment date or, in the event the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the most recent U.S. dollar/euro exchange rate
published in The Wall Street Journal on or prior to the second Business Day prior to the relevant payment date. Any payment in respect of the Notes so made in U.S. dollars shall not constitute an Event of Default under the Notes and the Indenture.
Neither the Trustee nor the London Paying Agent shall have any responsibility for any calculation or conversion in connection with the foregoing. Any references elsewhere in the Indenture or the Notes to payments being made in euro notwithstanding
shall be made in U.S. dollars to the extent set forth in this Section 1.2(12). 
 (13) The London Paying Agent for the Notes shall
initially be The Bank of New York Mellon, London Branch. The Company hereby initially designates the Specified Office of the London Paying Agent as the office to be maintained by it where Notes may be presented for

  
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payment, registration of transfer or exchange, and where notices to or demands upon the Company in respect of the Notes or the Indenture may be served. The Security Registrar for the Notes shall
initially be The Bank of New York Mellon, London Branch. The Company reserves the right at any time to vary or terminate the appointment of any London Paying Agent or Security Registrar, to appoint additional or other London Paying Agents or
Security Registrars and to approve any change in the office through which any Paying Agent or Security Registrar acts. 
 (14) In order to
provide for all payments due on the Notes as the same shall become due, the Company shall cause to be paid to the London Paying Agent, no later than 10:00 a.m. London time on the Business Day prior the payment date of each Note, at such bank as the
London Paying Agent shall previously have notified to the Company, in immediately available funds sufficient to meet all payments due on such Notes. 

(15) Notwithstanding any other provision of this Supplemental Indenture, the Trustee and London Paying Agent shall be entitled to make a
deduction or withholding from any payment which it makes under this Supplemental Indenture for or on account of any present or future taxes, duties or charges if and to the extent so required by any applicable law and any current or future
regulations or agreements thereunder or official interpretations thereof or any law implementing an intergovernmental approach thereto or by virtue of the relevant holder failing to satisfy any certification or other requirements in respect of the
Notes, in which event the Trustee or London Paying Agent shall make such payment after such withholding or deduction has been made and shall account to the relevant authorities for the amount so withheld or deducted and shall have no obligation to
gross up any payment hereunder or pay any additional amount as a result of such withholding tax. 
  

	Section 1.3	Optional Redemption. 

 (a) The provisions of Article Three of the Base Indenture, as
amended by the provisions of this Supplemental Indenture, shall apply to the Notes with respect to this Section 1.3. 
 (b) Prior to
September 1, 2020, the Notes shall be redeemable, in whole at any time or in part from time to time, at the Company’s option. Upon redemption of the Notes, the Company shall pay an Optional Redemption Price equal to the greater of: 

 

	 	(i)	100% of the principal amount of the Notes to be redeemed, and 

  

	 	(ii)	the sum of the present values of the Remaining Scheduled Payments of the Notes to be redeemed, discounted to the Optional Redemption Date on an annual basis (ACTUAL/ACTUAL (ICMA)) using a discount rate equal to the
Comparable Bond Rate, plus 25 basis points, 

 plus, in each case, in addition to such Optional Redemption Price, accrued and unpaid
interest on the Notes redeemed, if any, to, but excluding, the Optional Redemption Date. 
 In addition, on or after
September 1, 2020, the Notes shall be redeemable, in whole at any time or in part from time to time, at the Company’s option, at an Optional Redemption price equal to 100% of the principal amount of the Notes to be redeemed, plus, accrued
and unpaid interest, if any, to, but excluding, the Optional Redemption Date. 

  
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 The Notes shall also be redeemable, in whole, but not in part, at any time at the Company’s
option, at an Optional Redemption Price equal to 100% of the principal amount of the Notes, plus, accrued and unpaid interest and any Additional Amounts thereon, if the Company determines that (A) as a result of any change or amendment to the
laws, treaties, regulations or rulings of the United States of America or any political subdivision or taxing authority thereof, which change or amendment is announced and becomes effective on or after November 13, 2015, there is a material
probability that the Company has or will become obligated to pay Additional Amounts or (B) on or after November 13, 2015, any change in the official application, enforcement or interpretation of those laws, treaties, regulations or
rulings, including a holding by a court of competent jurisdiction in the United States or any other action, taken by any taxing authority or a court of competent jurisdiction in the United States, whether or not such action was taken or made with
respect to the Company, results in a material probability that the Company has or will become obligated to pay Additional Amounts on any Notes; provided that the Company determines, in its business judgment, that the obligation to pay such
Additional Amounts cannot be avoided by use of reasonable measures available to the Company, not including substitution of the obligor under the Notes. Prior to the mailing of any notice of such a redemption, the Company shall deliver to the Trustee
(1) an Officer’s Certificate stating that the Company is entitled to effect such a redemption and setting forth a statement of facts showing that the conditions precedent to the right of the Company to so redeem have occurred and
(2) an Opinion of Counsel to such effect based on such statement of facts. 
 (c) Notwithstanding the foregoing, installments of
interest whose Stated Maturity is on or prior to the Optional Redemption Date shall be payable on the applicable Interest Payment Date to the Securityholders of such Notes registered as such at the close of business on the applicable regular record
date pursuant to the Notes and the Indenture. 
 (d) On and after the Optional Redemption Date for the Notes, interest shall cease to accrue
on the Notes or any portion thereof called for redemption, unless the Company defaults in the payment of the Optional Redemption Price and accrued and unpaid interest and Additional Amounts, if any. No later than 10:00am London time on the Business
Day prior to the Optional Redemption Date for the Notes, the Company shall deposit with the Trustee or a paying agent, funds sufficient to pay the Optional Redemption Price of the Notes to be redeemed on the Optional Redemption Date, and (except if
the date fixed for redemption shall be an Interest Payment Date) accrued and unpaid interest and Additional Amounts, if any. If less than all of the Notes are to be redeemed, the Notes to be redeemed shall be selected, in the case of global
securities, in accordance with applicable Depositary procedures and in the case of definitive securities in a manner the trustee deems fair and appropriate, unless otherwise required by law or applicable stock exchange requirements. 

(e) Notice of any optional redemption shall be transmitted at least 15 days but not more than 60 days before the Optional Redemption Date to
each holder of the Notes to be redeemed; provided, however, that the Company shall notify the Trustee of the Optional Redemption Date at least 15 days prior to the date of the giving of such notice (unless a shorter notice shall be
satisfactory to the Trustee). Such notice shall be provided in accordance with 

  
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Section 3.02 of the Base Indenture. If the Optional Redemption Price cannot be determined at the time such notice is to be given, the actual Optional Redemption Price applicable to the Notes
that are being redeemed, calculated as described above in clause (b) shall be set forth in an Officers’ Certificate of the Company delivered to the Trustee no later than two (2) Business Days prior to the Optional Redemption Date.
Notice of redemption having been given as provided in the Indenture, the Notes called for redemption shall, on the Optional Redemption Date, become due and payable at the Optional Redemption Price, plus accrued and unpaid interest and Additional
Amounts, if any, to, but excluding, the Optional Redemption Date. 
  

	Section 1.4	Additional Covenants. 

 The following additional covenants shall apply with respect to
the Notes so long as any of the Notes remain Outstanding: 
 (1) Change of Control Triggering Event. 

(a) If a Change of Control Triggering Event occurs with respect to the Notes, unless the Company shall have redeemed the Notes in full, as set
forth in Section 1.3 of this Supplemental Indenture or the Company shall have defeased the Notes or have satisfied and discharged the Notes, as set forth in Article Eleven of the Base Indenture, the Company shall make an offer (the
“Change of Control Offer”) to each holder of the Notes to repurchase any and all of such holder’s Notes at a repurchase price in cash equal to 101% of the aggregate principal amount of the Notes to be repurchased (such
principal amount to be equal to €100,000 or any integral multiple of €1,000 in excess thereof), plus accrued and unpaid interest, if any, on the Notes to be repurchased up to, but excluding, the date of repurchase (the “Change of
Control Payment”). Within 30 days following any Change of Control Triggering Event, notice shall be transmitted to Holders of the Notes describing the transaction or transactions that constitute the Change of Control Triggering Event and
offering to repurchase the Notes on the date specified in the notice, which date will be no earlier than 15 days and no later than 60 days from the date such notice is delivered (the “Change of Control Payment Date”).
Notwithstanding the foregoing, installments of interest whose Stated Maturity is on or prior to the Change of Control Payment Date shall be payable on the applicable Interest Payment Date to the Securityholders of such Notes registered as such at
the close of business on the applicable regular record date pursuant to the Notes and the Indenture. 
 (b) On the Change of Control Payment
Date, the Company shall, to the extent lawful: 
  

	 	(i)	accept for payment all Notes or portions of Notes properly tendered pursuant to the Change of Control Offer; 

  

	 	(ii)	deposit with the Trustee or a paying agent an amount equal to the Change of Control Payment in respect of all Notes or portions of Notes properly tendered; and 

 

	 	(iii)	deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officers’ Certificate stating (1) the aggregate principal amount of Notes or portions of Notes being repurchased,
(2) that all conditions precedent contained herein to make a Change of Control Offer have been complied with and (3) that the Change of Control Offer has been made in compliance with the Indenture. 

  
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 The Company shall publicly announce the results of the Change of Control Offer on or as soon as
possible after the date of purchase. 
 The Company shall comply in all material respects with the requirements of Rule 14e-1 under the
Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that the
provisions of any such securities laws or regulations conflict with the Change of Control Offer provisions of this Section 1.4, the Company shall comply with the applicable securities laws and regulations and shall not be deemed to have
breached its obligations under this Section 1.4 by virtue of any such conflict. 
 (2) Additional Amounts. 

(a) All payments of principal and interest in respect of the Notes shall be made free and clear of, and without deduction or withholding for
or on account of any present or future taxes, duties, assessments or other governmental charges of whatsoever nature imposed, levied, collected, withheld or assessed by the United States or any political subdivision or taxing authority of or in the
United States, unless such withholding or deduction is required by law. 
 (b) The Company shall pay to a Holder of Notes who is not a
United States person additional amounts as may be necessary so that every net payment of the principal of and premium, if any, and interest on the Notes to such Holder, after deduction or withholding for or on account of any present or future tax,
assessment or other governmental charge imposed upon such Holder by the United States of America or any taxing authority thereof or therein, shall not be less than the amount provided in the Note to be then due and payable (such amounts, the
“Additional Amounts”); provided, however, that the Company shall not be required to make any payment of Additional Amounts for or on account of: 
  

	 	(i)	any tax, assessment or other governmental charge that would not have been imposed but for (A) the existence of any present or former connection (other than a connection arising solely from the ownership of those
Notes or the receipt of payments in respect of those Notes) between that Holder (or the beneficial owner for whose benefit such Holder holds such Notes), or between a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a
power over, that Holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or corporation, and the United States, including that Holder or beneficial owner, or that fiduciary, settlor, beneficiary, member,
shareholder or possessor being or having been a citizen or resident or treated as a resident of the United States or being or having been engaged in trade or business or present in the United States or having had a permanent establishment in the
United States or (B) the presentation of a debt security for payment on a date more than 30 days after the later of the date on which that payment becomes due and payable and the date on which payment is duly provided for; 

  
 11 

	 	(ii)	any estate, inheritance, gift, sales, transfer, excise, personal property, wealth, capital gains, interest equalization or similar tax, assessment or other governmental charge; 

 

	 	(iii)	any tax, assessment or other governmental charge imposed on foreign personal holding company income or by reason of a Holder (or the beneficial owner for whose benefit such Holder holds such Notes), or a fiduciary,
settlor, beneficiary of, member or shareholder of, or possessor of a power over, the Holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or corporation, being or having been a passive foreign investment
company, a controlled foreign corporation, a foreign tax exempt organization or a personal holding company with respect to the United States or a corporation that accumulates earnings to avoid U.S. federal income tax; 

 

	 	(iv)	any tax, assessment or other governmental charge which is payable otherwise than by withholding from payment of principal of or premium, if any, or interest on the Notes of that Holder; 

 

	 	(v)	any tax, assessment or other governmental charge required to be withheld by any paying agent from any payment of principal of or premium, if any, or interest on the Notes of that Holder if such payment can be made
without withholding by any other paying agent; 

  

	 	(vi)	any tax, assessment or other governmental charge which would not have been imposed but for the failure of a Holder (or the beneficial owner for whose benefit such Holder holds the Notes), or a fiduciary, settlor,
beneficiary of, member or shareholder of, or possessor of power over, the holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or corporation, or any intermediary through which a beneficial owner holds
Notes to comply with certification, information, documentation or other reporting requirements concerning the nationality, residence, identity or connections with the United States of America of the beneficial owner or any Holder of the Notes
(including, but not limited to, the requirement to provide Internal Revenue Service Forms W-8BEN, Forms W-8BEN-E, Forms W-8ECI, or any subsequent versions thereof or successor thereto, and including, without limitation, any documentation requirement
under an applicable income tax treaty); 

  

	 	(vii)	 any tax, assessment or other governmental charge imposed as a result of a Holder (or the beneficial owner for whose benefit such Holder holds such
Notes), or a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a power over, the Holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or corporation, being or

  
 12 

	 	
having been (A) a 10% shareholder (as defined in Section 871(h)(3)(B) of the Internal Revenue Code, and the regulations that may be promulgated thereunder) of the Company or (B) a
controlled foreign corporation that is related to the Company within the meaning of Section 864(d)(4) of the Internal Revenue Code or (C) a bank receiving interest described in Section 881(c)(3)(A) of the Internal Revenue Code;

  

	 	(viii)	any withholding or deduction that is imposed on a payment to an individual and is required to be made pursuant to European Council Directive 2003/48/EC relating to the taxation of savings, or any law implementing or
complying with, or introduced in order to conform to, such Directive (or any amended or successor version); 

  

	 	(ix)	any tax, assessment or other governmental charge that would not have been imposed but for a change in law, regulation, or administrative or judicial interpretation that becomes effective more than 15 days after the
payment becomes due or is duly provided for, whichever occurs later; 

  

	 	(x)	any taxes payable under Sections 1471 through 1474 of the Internal Revenue Code (or any amended or successor version of such Sections), any current or future regulations or other guidance thereunder, or any agreement
(including any intergovernmental agreement) entered into in connection therewith; or 

  

	 	(xi)	any combination of items (i), (ii), (iii), (iv), (v), (vi), (vii), (viii), (ix) and (x) above; 

nor shall any Additional Amounts be paid to any Holder that is not the sole beneficial owner of the Notes, or a portion of the Notes,
or that is a fiduciary, partnership or limited liability company to the extent that a beneficial owner with respect to the Holder, a beneficiary or settlor with respect to the fiduciary or a member of that partnership, limited liability company or a
beneficial owner thereof would not have been entitled to the payment of those Additional Amounts had that beneficiary, settlor, member or beneficial owner received directly its beneficial or distributive share of the payment. 

 

	Section 1.5	Events of Default. 

 (a) The provisions of Article VI of the Base Indenture shall be
applicable to the Notes, except that clauses (1) through (7) of Section 6.01(a) shall be modified with respect to the Notes as follows: 

(1) default in the payment of the principal or any premium on the Notes when due (whether at maturity, upon acceleration,
redemption or otherwise); 
 (2) default for 30 days in the payment of interest on the Notes when due; 

(3) (i) failure by the Company to comply with Section 1.4(1) of this Supplemental Indenture or (ii) failure by the
Company to observe or perform any term of 

  
 13 

 
the Indenture (other than those referred to in (1) or (2) above or (3)(i) above) for a period of 90 days after the Company receives a notice of default stating that the Company is
in breach. The notice required under 3(ii) above must be sent by either the Trustee or Holders of 25% of the principal amount of the Notes; 

(4) (A) failure by the Company to pay indebtedness for money borrowed by the Company or for which the Company has guaranteed
the payment, in an aggregate principal amount of at least $100,000,000, at the later of final maturity and the expiration of any related applicable grace period and such defaulted payment shall not have been made, waived or extended within 30 days
or (B) acceleration of the maturity of any indebtedness for money borrowed by the Company or for which the Company has guaranteed the payment, in an aggregate principal amount of at least $100,000,000, if such indebtedness has not been
discharged in full or such acceleration has not been rescinded or annulled within 30 days; provided, however, that, if the default under the instrument is cured by the Company, or waived by the holders of the indebtedness, in each case
as permitted by the governing instrument, then the Event of Default under the Indenture caused by such default will be deemed likewise to be cured or waived; 

(5) the entry by a court having competent jurisdiction of: 

(A) an order for relief in respect of the Company as debtor in an involuntary proceeding under any applicable Bankruptcy Law
and such order shall remain unstayed and in effect for a period of 60 consecutive days; or 
 (B) a final and non-appealable
order appointing a Custodian of the Company, or ordering the winding up or liquidation of the affairs of the Company, and such order shall remain unstayed and in effect for a period of 60 consecutive days; or 

(6) the commencement by the Company of a voluntary proceeding under any applicable Bankruptcy Law or the consent by the Company
as debtor to the entry of a decree or order for relief in an involuntary proceeding under any applicable Bankruptcy Law, or the filing by the Company as debtor of a consent to an order for relief in any involuntary proceeding under any Bankruptcy
Law, or to the appointment of a Custodian or the making by the Company of an assignment for the benefit of creditors. 
 ARTICLE II 

MISCELLANEOUS 
  

	Section 2.1	Business Day 

 If any Interest Payment Date, maturity date or earlier date of redemption
falls on a day that is not a Business Day, the required payment shall be made on the next Business Day as if it were made on the date the payment to holders was due and no interest shall accrue on the amount so payable for the period from and after
that Interest Payment Date, that maturity date or that date of redemption, as the case may be. 

  
 14 

	Section 2.2	Definitions. 

 Capitalized terms used but not defined in this Supplemental Indenture
shall have the meanings ascribed thereto in the Base Indenture. 
  

	Section 2.3	Confirmation of Indenture. 

 The Base Indenture, as supplemented and amended by this
Supplemental Indenture, is in all respects ratified and confirmed, and the Base Indenture, this Supplemental Indenture and all indentures supplemental thereto shall be read, taken and construed as one and the same instrument. 

 

	Section 2.4	Concerning the Trustee and London Paying Agent. 

 In carrying out the their respective
responsibilities hereunder, the Trustee and the London Paying Agent shall have all of the rights, protections and immunities which they possess under the Indenture. The recitals contained herein and in the Notes, except the Trustee’s
certificate of authentication, shall be taken as the statements of the Company, and the Trustee and London Paying Agent assume no responsibility for their correctness. The Trustee and London Paying Agent make no representations as to the validity or
sufficiency of this Supplemental Indenture or of the Notes. The Trustee and London Paying Agent shall not be accountable for the use or application by the Company of the Notes or the proceeds thereof. 

 

	Section 2.5	Governing Law. 

 This Supplemental Indenture and the Notes shall be deemed to be a
contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the laws of said State. 
  

	Section 2.6	Separability. 

 In case any provision in this Supplemental Indenture shall for any reason
be held to be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
  

	Section 2.7	Counterparts. 

 This Supplemental Indenture may be executed in any number of counterparts
each of which shall be an original, but such counterparts shall together constitute but one and the same instrument. 
  

	Section 2.8	No Benefit. 

 Nothing in this Supplemental Indenture, express or implied, shall give to
any Person other than the parties hereto and their successors or assigns, and the holders of the Notes, any benefit or legal or equitable rights, remedy or claim under this Supplemental Indenture or the Base Indenture. 

  
 15 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed all as of the day and year first above written. 
  

			
	THERMO FISHER SCIENTIFIC INC.
		
	By:	 	 /s/ Anthony Smith

	Name:	 	Anthony Smith
	Title:	 	Vice President, Tax and Treasury and Treasurer

  
 Tenth Supplemental
Indenture 

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
		
	By:	 	 /s/ Lawrence M. Kusch

	Name:	 	Lawrence M. Kusch
	Title:	 	Vice President

  
 Tenth Supplemental
Indenture 

			
	THE BANK OF NEW YORK MELLON, LONDON BRANCH, as London Paying Agent
		
	By:	 	 /s/ Paul Cattermole

	Name:	 	Paul Cattermole
	Title:	 	Vice President

  
 Tenth Supplemental
Indenture 

 EXHIBIT A 

[Insert the Global Security legend, if applicable] 

1.500% SENIOR NOTES DUE 2020 
  

			
	 No. [    ]
 ISIN No.
XS1322986537
	  	€[    ]        

 THERMO FISHER SCIENTIFIC INC. 

promises to pay to [            ] or registered assigns, the principal sum of
[            ] Euros on December 1, 2020. 
 Interest Payment Date: December 1 

Record Date: November 15 
 Each holder of
this Security (as defined below), by accepting the same, agrees to and shall be bound by the provisions hereof and of the Indenture described herein, and authorizes and directs the Trustee described herein on such holder’s behalf to be bound by
such provisions. Each holder of this Security hereby waives all notice of the acceptance of the provisions contained herein and in the Indenture and waives reliance by such holder upon said provisions. 

This Security shall not be entitled to any benefit under the Indenture, or be valid or become obligatory for any purpose, until the
Certificate of Authentication hereon shall have been signed by or on behalf of the Trustee. The provisions of this Security are continued on the reverse side hereof, and such continued provisions shall for all purposes have the same effect as though
fully set forth at this place. 

  
 1 

 IN WITNESS WHEREOF, the Company has caused this instrument to be signed in accordance with Section 2.04 of
the Base Indenture. 
 Date: November 24, 2015 
  

			
	THERMO FISHER SCIENTIFIC INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

  
 2 

 CERTIFICATE OF AUTHENTICATION 

This is one of the 1.500% Senior Notes due 2020 issued by Thermo Fisher Scientific Inc. of the series designated therein, referred to in the within-mentioned
Indenture. 
 Date: November 24, 2015 
  

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. as Trustee
		
	By:	 	  

		 	Authorized Signatory

  
 3 

 Thermo Fisher Scientific Inc. 

1.500% Senior Notes due 2020 
 This
security is one of a duly authorized series of debt securities of Thermo Fisher Scientific Inc., a Delaware corporation (the “Company”), issued or to be issued in one or more series under and pursuant to an Indenture for the
Company’s unsubordinated debt securities, dated as of November 20, 2009 (the “Base Indenture”), duly executed and delivered by and among the Company and The Bank of New York Mellon Trust Company, N.A. (the
“Trustee”), as supplemented by the Tenth Supplemental Indenture, dated as of November 24, 2015 (the “Tenth Supplemental Indenture”), among the Company, the Trustee and The Bank of New York Mellon, London
Branch, as London paying agent (the “London Paying Agent”). The Base Indenture as supplemented and amended by the Tenth Supplemental Indenture is referred to herein as the “Indenture.” By the terms of the Base
Indenture, the debt securities issuable thereunder are issuable in series that may vary as to amount, date of maturity, rate of interest and in other respects as provided in the Base Indenture. This security is one of the series designated on the
face hereof (individually, a “Security,” and collectively, the “Securities”), and reference is hereby made to the Indenture for a description of the rights, limitations of rights, obligations, duties and immunities
of the Trustee, the Company and the holders of the Securities (the “Securityholders”). Capitalized terms used herein and not otherwise defined shall have the meanings given them in the Base Indenture or the Tenth Supplemental
Indenture, as applicable. 
 1. Interest. The Company promises to pay interest on the principal amount of this Security
at an annual rate of 1.500%. The Company will pay interest annually in arrears on December 1 of each year (each such day, an “Interest Payment Date”) until the principal is paid or made available for payment. If any Interest
Payment Date, redemption date or maturity date of this Security is not a Business Day, then payment of interest or principal (and premium, if any) shall be made on the next succeeding Business Day with the same force and effect as if made on the
date such payment was due, and no interest shall accrue for the period after such date to the date of such payment on the next succeeding Business Day. Interest on the Securities will accrue from the most recent date to which interest has been paid
or duly made available for payment or, if no interest has been paid, from the date of issuance; provided that, if there is no existing Default in the payment of interest, and if this Security is authenticated between a regular record date referred
to on the face hereof and the next succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date; and provided, further, that the first Interest Payment Date shall be December 1, 2016. Interest on the
Securities shall be computed on the basis of an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of ICMA) day count convention. In order to provide for all payments due on the Securities as the same shall become due, the Company shall cause to be
paid to the London Paying Agent, no later than 10:00 a.m. London time on the Business Day prior the payment date of each Security, at such bank as the London Paying Agent shall previously have notified to the Company, in immediately available funds
sufficient to meet all payments due on such Securities. 
 2. Method of Payment. The Company will pay interest on the
Securities (except defaulted interest), if any, to the persons in whose name such Securities are registered at the close of business on the regular record date referred to on the facing page of this Security for such interest installment. In the
event that the Securities or a portion thereof are called for 

  
 4 

 
redemption pursuant to an optional redemption or there is a Change of Control Offer, and the Optional Redemption Date or the Change of Control Payment Date, as applicable, is subsequent to a
regular record date with respect to any Interest Payment Date and prior to such Interest Payment Date, interest on such Securities shall instead be paid upon presentation and surrender of such Securities as provided in the Indenture. Subject to
Section 1.2 of the Tenth Supplemental Indenture, all payments of principal of, and interest (including Additional Amounts, if any) and premium (if any) on, the Securities shall be payable in euro. 

3. Paying Agent and Registrar. Initially, The Bank of New York Mellon, London Branch, shall act as paying agent and Security Registrar.
The Company may change or appoint any paying agent or Security Registrar without notice to any Securityholder. The Company or any of their Subsidiaries may act in any such capacity. 

4. Indenture. The terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to
the Trust Indenture Act of 1939 (“TIA”) as in effect on the date the Indenture is qualified. The Securities are subject to all such terms, and Securityholders are referred to the Indenture and TIA for a statement of such terms. In
the event of a conflict between the terms of the Securities and the terms of the Indenture, the terms of the Indenture shall prevail. The Securities are unsecured general obligations of the Company and constitute the series designated on the face
hereof as the “1.500% Senior Notes due 2020”, initially limited to €425,000,000 in aggregate principal amount. The Company shall furnish to any Securityholder upon written request and without charge a copy of the Base Indenture and
the Tenth Supplemental Indenture. Requests may be made to: Thermo Fisher Scientific Inc., 81 Wyman Street Waltham, Massachusetts, Attention: Seth H. Hoogasian. 

5. Redemption. The Securities may be redeemed at the option of the Company prior to the maturity date, as provided in Section 1.3
of the Tenth Supplemental Indenture. The Company shall not be required to make sinking fund payments with respect to the Securities. 
 6.
Payment of Additional Amounts. All payments of principal and interest in respect of the Securities shall be made free and clear of, and without deduction or withholding for or on account of any present or future taxes, duties, assessments or
other governmental charges of whatsoever nature imposed, levied, collected, withheld or assessed by the United States or any political subdivision or taxing authority of or in the United States, unless such withholding or deduction is required by
law. The Company shall pay to a Holder of Securities who is not a United States person additional amounts as may be necessary so that every net payment of the principal of and premium, if any, and interest on the Securities to such Holder, after
deduction or withholding for or on account of any present or future tax, assessment or other governmental charge imposed upon such Holder by the United States of America or any taxing authority thereof or therein, shall not be less than the amount
provided in the Securities to be then due and payable (such amounts, the “Additional Amounts”); provided, however, that the Company shall not be required to make any payment of Additional Amounts under certain circumstances provided
in Section 1.4(2)(b) of the Tenth Supplemental Indenture. 
 7. Change of Control Triggering Event. Upon the occurrence of a
Change of Control Triggering Event, unless the Company has redeemed this Security or the Company has defeased this Security or satisfied and discharged this Security, the holder of this Security shall

  
 5 

 
have the right to require that the Company purchase all or a portion (such principal amount to be equal to €100,000 or any integral multiple of €1,000 in excess thereof) of this
Security at a purchase price equal to 101% of the aggregate principal amount repurchased plus accrued and unpaid interest, if any, on the amount to be repurchased up to but excluding the date of purchase. Within 30 days following any Change of
Control Triggering Event, the Company shall send, by first class mail, a notice to each Holder, in accordance with Section 1.4(1)(a) of the Tenth Supplemental Indenture, with a copy to the Trustee, which notice shall govern the terms of the
Change of Control Offer. 
 8. Denominations, Transfer, Exchange. The Securities are in registered form without coupons in the
denominations of €100,000 or any integral multiple of €1,000 in excess thereof. The transfer of Securities may be registered and Securities may be exchanged as provided in the Indenture. The Securities may be presented for exchange or for
registration of transfer (duly endorsed or with the form of transfer endorsed thereon duly executed if so required by the Company or the Security Registrar) at the office of the Security Registrar or at the office of any transfer agent designated by
the Company for such purpose. No service charge shall be made for any registration of transfer or exchange, but a Securityholder may be required to pay any applicable taxes or other governmental charges. If the Securities are to be redeemed, the
Company shall not be required to: (i) issue, register the transfer of, or exchange any Security during a period beginning at the opening of business 15 days before the day of mailing of a notice of redemption of less than all of the outstanding
Securities and ending at the close of business on the day of such mailing; (ii) register the transfer of or exchange any Security or portions thereof selected for redemption, in whole or in part, except the unredeemed portions of any such
Security being redeemed in part; nor (iii) register the transfer of or exchange of a Security between the applicable record date and the next succeeding Interest Payment Date. 

9. Persons Deemed Owners. The registered Securityholder may be treated as its owner for all purposes. 

10. Repayment to the Company. Any funds or Governmental Obligations deposited with any paying agent or the Trustee, or then held by the
Company, in trust for payment of principal of, premium, if any, or interest on the Securities that are not applied but remain unclaimed by the holders of such Securities for at least one year after the date upon which the principal of, premium, if
any, or interest on such Securities shall have respectively become due and payable, shall be repaid to the Company, as applicable, or (if then held by the Company) shall be discharged from such trust. After return to the Company, Holders entitled to
the money or securities must look to the Company, as applicable, for payment as unsecured general creditors. 
 11. Amendments,
Supplements and Waivers. The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities to be affected
under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount of the Securities at the time Outstanding to be affected. The Indenture also contains provisions permitting the Holders
of a majority in principal amount of the Securities at the time Outstanding, on behalf of the Holders of all Securities, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults

  
 6 

 
under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security
and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

12. Defaults and Remedies. If an Event of Default with respect to the Securities occurs and is continuing, the Trustee or the holders
of at least 25% in aggregate principal amount of the Securities then Outstanding, by notice in writing to the Company (and to the Trustee if notice is given by such holders), may declare the entire principal of, premium, if any, and accrued
interest, if any, of such Securities due and payable immediately. Subject to the terms of the Indenture, if an Event of Default under the Indenture shall occur and be continuing, the Trustee shall be under no obligation to exercise any of its rights
or powers under the Indenture at the request or direction of any of the holders, unless such holders have offered the Trustee indemnity satisfactory to it. Upon satisfaction of certain conditions set forth in the Indenture, the holders of a majority
in principal amount of the Outstanding Securities shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any trust or power conferred on the Trustee, with respect
to the Securities. 
 13. Trustee, Paying Agent and Security Registrar May Hold Securities. The Trustee, subject to certain
limitations imposed by the TIA, or any paying agent or Security Registrar, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if it were not Trustee, paying agent or Security
Registrar. 
 14. No Recourse Against Others. No recourse under or upon any obligation, covenant or agreement of the Indenture, or of
any Security, or for any claim based thereon or otherwise in respect hereof or thereof, shall be had against any incorporator, stockholder, officer or director, past, present or future as such, of the Company or of any predecessor or successor
corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue of any constitution, statute or rule of law, or by the enforcement of any assessment or penalty or otherwise; it being expressly
understood that the Indenture and the obligations issued hereunder and thereunder are solely corporate obligations, and that no such personal liability whatever shall attach to, or is or shall be incurred by, the incorporators, stockholders,
officers or directors as such, of the Company or of any predecessor or successor corporation, or any of them, because of the creation of the indebtedness authorized by the Indenture, or under or by reason of the obligations, covenants or agreements
contained in the Indenture or in the Securities or implied therefrom; and that any and all such personal liability of every name and nature, either at common law or in equity or by constitution or statute, of, and any and all such rights and claims
against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness authorized by the Indenture, or under or by reason of the obligations, covenants or agreements contained in the Indenture or in
the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the acceptance of the Securities. 

15. Discharge of Indenture. The Indenture contains certain provisions pertaining to discharge and defeasance, which provisions shall
for all purposes have the same effect as if set forth herein. 

  
 7 

 16. Authentication. This Security shall not be valid until the Trustee signs the
certificate of authentication attached to the other side of this Security. 
 17. Additional Amounts. The Company is obligated to pay
Other Additional Amounts on this Security to the extent provided in Section 10.03 of the Base Indenture. 
 18. Abbreviations.
Customary abbreviations may be used in the name of a Securityholder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (=tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST
(=Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 
 19. Governing Law. The Base Indenture, the Tenth Supplemental Indenture
and this Security shall be deemed to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the laws of said State. 

  
 8 

 ASSIGNMENT FORM 

To assign this Security, fill in the form below: (I) or (we) assign and transfer this Security to 

 

	
	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	
	  

	  

	  

	  

	(Print or type assignee’s name, address and zip code)

 and irrevocably appoint
                                         agent to
transfer this Security on the books of the Company. The agent may substitute another to act for him. 
  

			
	Date:	 	  

  

			
	Your Signature	 	  

	(Sign exactly as your name appears on the face of this Security)

  

			
	Signature Guarantee:	 	  

  
 A-1 

 OPTION OF HOLDER TO ELECT PURCHASE 

If you want to elect to have this Security purchased by the Company pursuant to Section 1.4(l) of the Tenth Supplemental Indenture, check
the box: 
  

	 ̈	1.4(l) Change of Control Triggering Event 

 If you want to elect to have only part of this
Security purchased by the Company pursuant to Section 1.4(l) of the Tenth Supplemental Indenture, state the amount: €         

 

									
	Date:	 	  
	 		 	Your Signature	 	  

		 		 		 	(Sign exactly as your name appears on the face of this Security)

  

							
		 	Tax I.D. Number:	 	  
	 	

  

			
	Signature Guarantee:	 	  

	 (Signature must be guaranteed by a participant in a recognized signature guarantee medallion program)

  
 A-2EX-4.3

 Exhibit 4.3 

Dated: November 24, 2015 

Thermo Fisher Scientific Inc.  

as Issuer 
 and 

The Bank of New York Mellon, London Branch  

as Paying Agent 
 PAYING AGENCY
AGREEMENT 

 THIS AGREEMENT (this “Agreement”) is made as of November 24, 2015
between Thermo Fisher Scientific Inc. (the “Issuer”), and The Bank of New York Mellon, London Branch, as paying agent (the “Paying Agent”), located at One Canada Square, London E14 5AL. 

WHEREAS, the Issuer proposes to issue (i) Euro denominated 1.500% Senior Notes due 2020 in the form attached hereto as Annex A
(the “Notes”) in the aggregate principal amount of €425,000,000 on the date hereof, pursuant to the Indenture, dated as of November 20, 2009 (the “Base Indenture”), duly executed and delivered by and
between the Issuer and The Bank of New York Mellon Trust Company, N.A. (the “Trustee”), as supplemented by the Tenth Supplemental Indenture, dated as of November 24, 2015 (together with the Base Indenture, the
“Indenture”) among the Issuer, the Trustee and the Paying Agent; 
 WHEREAS, solely with respect to the Notes, the
Issuer wishes to appoint the Paying Agent, as set forth above, upon the terms and subject to the conditions set forth herein; 
 NOW,
THEREFORE, in consideration of the mutual promises contained herein, the parties hereto agree as follows: 
  

	1.	Definitions 

  

	1.1	All capitalized terms used herein, but not defined, shall have the meanings given to them in the Indenture. 

  

	1.2	In addition, the following terms shall have the following meanings: 

“Business Day” means any day, other than a Saturday or Sunday, (1) which is not a day on which
banking institutions in The City of New York or London are authorized or required by law, regulation or executive order to close and (2) on which the Trans-European Automated Real-Time Gross Settlement Express Transfer system (the TARGET2
system), or any successor thereto, is open. 
 “Holder(s)” means the person or persons in
whose name or names the Note is registered in the Security Register (as defined in the Base Indenture). 
 References
to the records of Euroclear and Clearstream, Luxembourg shall be to the records that each of Euroclear and Clearstream, Luxembourg holds for its customers which reflect the amount of such customers’ interests in the Notes. 

 

	2.	Appointment of Paying Agent 

 The Issuer hereby appoints The Bank of New
York Mellon, London Branch, at its office specified above as the paying agent solely in respect of the Notes upon the terms and conditions herein contained, and The Bank of New York Mellon, London Branch, accepts such appointment. In the event of
any inconsistency between the Indenture and this Agreement, the terms of the Indenture shall prevail. 

  
 - 1 - 

	3.	Payment 

  

	3.1	In order to provide for all payments due on the Notes as the same shall become due, the Issuer shall cause to be paid to the Paying Agent, no later than 10:00 a.m. London time on the Business Day prior the
payment date of each Note, at such bank as the Paying Agent shall previously have notified to the Issuer, in immediately available funds sufficient to meet all payments due on such Notes. 

 

	3.2	The Issuer hereby authorizes and directs the Paying Agent, from the amounts paid to it pursuant to this Section 3, to make or cause to be made all payments on the Notes in accordance with the terms thereof.
Such payments shall be made to the Holder or Holders of Notes in accordance with the terms of the Notes, the provisions contained in this Agreement, and the procedures of Euroclear and Clearstream. All interest payments in respect of the Notes will
be made by the Paying Agent on the relevant interest payment date (as set forth in the Note) to the Holders in whose names the Notes are registered at the close of business (New York) on the record date specified in the Notes next preceding the
interest payment date or such other date as is provided in the Notes. So long as the Notes are represented by a single global certificate and registered in the name of Euroclear and Clearstream or its nominee, all interest payments on the Notes
shall be made by the Paying Agent by wire transfer of immediately available funds in euros to Euroclear and Clearstream. 

  

	3.3	The Paying Agent will pay the principal amount of each Note on the applicable maturity date or upon any redemption date with respect thereto, together with accrued and unpaid interest due at maturity or such
redemption date, if any, upon presentation and surrender of such Note on or after the maturity date or redemption date thereof to the Paying Agent, or as specified in the Notes. 

 

	3.4	If for any reason the amounts received by the Paying Agent are insufficient to satisfy all claims in respect of all payments then due on the Notes, the Paying Agent shall forthwith notify the Issuer, and the
Paying Agent shall not be obliged to pay any such claims until the Paying Agent has received the full amount of the monies then due and payable in respect of such Notes. If, however, the Paying Agent in its sole discretion shall make payment on the
Notes on their maturity, redemption, payments of interest or such other payments when otherwise due (it being understood that the Paying Agent shall have no obligation whatsoever to make any such payment) and the amount which should have been
received is not received on such date, the Issuer agrees forthwith on demand to pay, or procure the payment of, to the Paying Agent, in addition to the amount which should have been paid hereunder, interest thereon from the day following the date
when the amount unpaid should have been received under this Agreement to the date when such amount is actually received (inclusive) at a rate equal to the cost of the Paying Agent of funding such amount, as certified by the Paying Agent and
expressed as a rate per annum. 

  

	3.5	The Paying Agent hereby agrees that: 

  

	 	(i)	 it will hold all sums held by it as Paying Agent for the payment of the principal or interest, if any, on the Notes in trust for the benefit of the

  
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Holders of the Notes entitled thereto, or for the benefit of the Trustee, as the case may be, until such sums shall be paid out to such Holders or otherwise as provided in Section 3.6 below
and in the Indenture; 

  

	 	(ii)	it will promptly give the Trustee notice of: (x) an Issuer deposit for the payment of principal of or interest, if any, on the Notes, (y) any failure by the Issuer in the making of any deposit for the payment
of principal of or interest, if any, on the Notes that shall have become payable, and (z) any default by the Issuer in making any payment of the principal of or interest, if any, on the Notes where the same shall be due and payable as provided
in the Notes; and 

  

	 	(iii)	at any time after an Event of Default in respect of the Notes shall have occurred, Paying Agent shall, if so required by notice in writing given by the Trustee to the Paying Agent: (y) thereafter, until otherwise
instructed by the Trustee, act as agent of the Trustee under the terms of the Indenture; and/or (z) deliver all Notes and all sums, documents and records held by the Paying Agent in respect of the Notes to the Trustee or as the Trustee shall
direct in such notice; provided that such notice shall be deemed not to apply to any document or record which the Paying Agent is obliged not to release by any applicable law or regulation. 

 

	3.6	Notwithstanding the foregoing, 

  

	 	(i)	if any Note is presented or surrendered for payment to the Paying Agent and the Paying Agent has delivered a replacement therefor or has been notified that the same has been replaced, the Paying Agent shall as soon as
is reasonably practicable notify the Issuer in writing of such presentation or surrender and shall not make payment against the same until it is so instructed by the Issuer and has received the amount to be so paid; and 

 

	 	(ii)	the Paying Agent shall cancel each Note against surrender of which it has made full payment and shall deliver each Note so cancelled by it to the Trustee. 

 

	3.7	In no event, shall the Paying Agent be obliged to make any payments hereunder if it has not received the full amount of any payment. 

 

	4.	Indemnity 

  

	4.1	 The Issuer shall indemnify and keep indemnified the Paying Agent against any losses, liabilities, costs, claims, actions or demands which it
may incur or which may be made against it as a result of or in connection with its appointment or the exercise of its powers and duties under this Agreement or in respect of the Issuer’s issue of Notes, except to the extent that they have
resulted from the Paying Agent’s negligence or bad faith. The Paying Agent shall notify the Issuer promptly of any claim for which it may seek indemnity. The failure of the Paying Agent to so notify the Issuer will relieve it from any liability
which it may have to the Paying Agent for contribution or otherwise under the 

  
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indemnity contained in this Section, but only to the extent that the Issuer is materially prejudiced as a proximate result of such failure. The Issuer shall defend the claim and the Paying Agent
shall cooperate in the defense. The Paying Agent may have separate counsel in any such defense, but the fees and expenses of such counsel shall be at the expense of the Paying Agent, unless: (i) the employment of such counsel has been
specifically authorized in writing by the Issuer; (ii) the Issuer has failed promptly to assume the defense and employ counsel reasonably satisfactory to the Paying Agent; or (iii) the named parties to any such action (including any
impleaded parties) include both the Paying Agent and the Issuer or any affiliate of the Issuer, and such Paying Agent shall have reasonably concluded that either (x) there may be one or more legal defenses available to it which are different
from or additional to those available to the Issuer or such affiliate of the Issuer or (y) a conflict may exist between the Paying Agent and the Issuer or such affiliate of the Issuer. The Issuer need not pay for any settlement without its
consent. 

  

	4.2	The indemnity contained in this Section shall survive the termination or expiry of this Agreement and the resignation or removal of the Paying Agent. 

 

	5.	General 

  

	5.1	In acting under this Agreement, the Paying Agent shall not (a) be under any fiduciary duty towards any person, (b) be responsible for or liable in respect of the authorization, validity or legality of
any Note amount paid by it hereunder (except to the extent that any such liability is determined by a court of competent jurisdiction to have resulted from the Paying Agent’s gross negligence or willful misconduct), (c) be under any
obligation towards any person other than the Trustee and Issuer or (d) assume any relationship of agency or trust for or with any Holder. 

  

	5.2	The Paying Agent shall be entitled to treat the registered Holder of any Note as the absolute owner of such Note for all purposes and make payments thereon accordingly. 

 

	5.3	The Paying Agent may exercise any of its rights or duties hereunder by or through agents or attorneys, and shall not be responsible for any misconduct thereof, provided such agent or attorney has been appointed
by due care and each such agent making any payment on the Notes is a United States person (as defined in Section 7701(a)(30) of the Code) that is a “financial institution” within the meaning of Treasury Regulation
Section 1.1441-1(c)(5) and a US financial institution within the meaning of Treasury Regulation Section 1.1471-1(b)(127). 

  

	5.4	The Paying Agent shall not exercise any lien, right of set-off or similar claim against any Holder of a Note in respect of moneys payable by it under this Agreement; however, should Paying Agent elect to make a
payment pursuant to Section 3.4 thereof, it shall be entitled to appropriate for its own account out of the funds received by it under Section 3 an amount equal to the amount so paid by it. 

  
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	5.5	The Paying Agent may (at the expense of the Issuer) consult on any matter concerning its duties hereunder any legal adviser or other expert selected by it, and the Paying Agent shall not be liable in respect of
anything done, or omitted to be done in reasonable reliance on that adviser’s opinion. At any time, the Paying Agent may apply to any duly authorized representative of the Issuer for a written instruction, and shall not be liable for action
taken or omitted to be taken in accordance with such instruction. 

  

	5.6	The Paying Agent shall be entitled to rely, and shall not be liable in respect of anything done or suffered by it in reliance, on any notice, document, communication or information reasonably believed in good
faith by it to be genuine and given by the proper parties. 

  

	5.7	The Paying Agent shall be obliged to perform only such duties as are specifically set forth herein and in the Notes, and no implied duties or obligations shall be read into this Agreement or the Notes against the
Paying Agent. 

  

	5.8	The Paying Agent shall not be liable to account to the Issuer for any interest or other amounts in respect of funds received by it from the Issuer. Money held by the Paying Agent need not be segregated except as
required by law. 

  

	5.9	No provision of this Agreement or the Notes shall require the Paying Agent to risk or expend its own funds, or to take any action which in its reasonable judgment would result in any expense or liability accruing
to it. 

  

	5.10	In no event will the Paying Agent be responsible or liable for any failure or delay in the performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control,
including, without limitation, strikes, work stoppages, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions, severe loss or malfunctions of utilities, communications or computer
(software and hardware) services; it being understood that the Paying Agent will use reasonable efforts which are consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances.

  

	5.11	The Paying Agent shall have no duty to inquire as to the performance of the covenants of the Issuer, nor shall it be charged with knowledge of any default or Event of Default under the Indenture.

  

	5.12	Notwithstanding any provision of this Agreement to the contrary, the Paying Agent will not in any event be liable for special, punitive or consequential loss or damage of any kind whatsoever (including but not
limited to lost profits), whether or not foreseeable, even if the Paying Agent has been advised of the likelihood of such loss or damage and regardless of the form of action. 

 

	5.13	Reserved. 

  

	5.14	Reserved. 

  
 - 5 - 

	5.15	The Paying Agent, its officers, directors, employees and shareholders may become the owners of, or acquire any interest in, the Notes, with the same rights that it or they would have if it were not the Paying
Agent, and may engage or be interested in any financial or other transaction with the Issuer as freely as if it were not the Paying Agent. 

  

	5.16	Reserved. 

  

	5.17	The Paying Agent shall retain the right not to act and shall not be held liable for refusing to act unless it has received clear and reasonable documentation which complies with the terms of this Agreement.

  

	5.18	The Issuer will supply the Paying Agent with the names and specimen signatures of its authorized persons. 

  

	6.	Change of Paying Agent 

  

	6.1	Resignation or Removal of Paying Agent. Any time, other than on a day during the forty-five (45) day period preceding any payment date for Issuer’s Notes, the Paying Agent may resign by giving at
least forty-five (45) days’ prior written notice to Issuer; and the Paying Agent’s agency shall be terminated and its duties shall cease upon expiration of such forty-five (45) days or such lesser period of time as shall be
mutually agreeable to Paying Agent and Issuer. At any time, following at least forty-five (45) days’ prior written notice (or such lesser period of time as shall be mutually agreeable to the Paying Agent and the Issuer) from the Issuer,
the Paying Agent may be removed from its agency. Such removal shall become effective upon the expiration of the forty-five (45) day or agreed lesser time period, and upon payment to the Paying Agent of all amounts payable to it in connection
with its agency. In such event, following payment of its fees and expenses, the Paying Agent shall promptly deliver to the Issuer, or to the Issuer’s designated representative, all Notes (if any) and cash (if any) belonging to the Issuer and,
at the Issuer’s expense, shall furnish to the Issuer, or to the Issuer’s designated representative, such information regarding the status of the Issuer’s outstanding Notes reasonably requested by the Issuer. 

 

	6.2	Any corporation into which a Paying Agent may be merged or consolidated or any corporation resulting from any merger or consolidation to which such Paying Agent is a party or any corporation to which such Paying
Agent shall sell or otherwise transfer all or substantially all of its corporate trust or agency assets shall on the date on which such merger, consolidation or transfer becomes effective, become the successor to such Paying Agent under this
Agreement without the execution or filing of any paper or any further act on the part of the parties hereto; provided that such corporation provides the information required by Section 10.1 of this Agreement. 

 

	7.	Compensation, Fees and Expenses 

  

	7.1	The Issuer will pay to the Paying Agent the compensation, fees and expenses in respect of the Paying Agent’s services as separately agreed with the Paying Agent. 

 

	7.2	The Issuer will also pay all reasonable out-of-pocket expenses (including legal expenses) incurred by the Paying Agent in connection with its services hereunder, together with any applicable value added tax and
stamp, issue, or other documentary taxes and duties. 

  
 - 6 - 

	8.	Notices 

  

	8.1	Each notice or communication under this Agreement shall be made in writing, by fax or otherwise in accordance with this Section 8. Each communication or document to be delivered to any party under this
Agreement shall be sent to that party at the fax number or address, and marked for the attention of the person (if any), from time to time designated by that party to the Paying Agent (or, in the case of the Paying Agent, by it to each other party)
for the purpose of this Agreement. The initial telephone number, fax number, address and person so designated are: 

in the case of the Issuer, at: 
  

			
	Thermo Fisher Scientific Inc.
	81 Wyman Street
	Waltham, Massachusetts 02454
	Facsimile:	  	    (781) 622 – 1283
	Attention:	  	    Seth H. Hoogasian
	
	With a copy to:
	
	Wilmer Cutler Pickering Hale and Dorr LLP
	60 State Street
	Boston, Massachusetts 02109
	Facsimile:	  	    (617) 526 – 5000
	Attention:	  	    Erika Robinson

 in the case of the Paying Agent, to it at: 

 

			
	The Bank of New York Mellon, London Branch
	One Canada Square, London E14 5AL
	Attention: Corporate Trust Administration
	Fax no: +44 (0) 20 7964 2536
	
	With a copy to:
	
	The Bank of New York Mellon Trust Company, N.A.
	525 William Penn Place, 38th Floor
	Pittsburgh, PA 15259
	Fax no: +1 (412)234-7535

  

	8.2	All notices under this Agreement shall be effective (if by fax) when good receipt is confirmed by the recipient following enquiry by the sender and (if in writing) when delivered, except that a communication
received outside normal business hours shall be deemed to be received on the next Business Day in the city in which the recipient is located. 

  
 - 7 - 

	8.3	In no event, shall the Paying Agent be liable for any losses arising from the Paying Agent receiving or transmitting any data from or to an authorized person via any non-secure method of transmission or
communication, such as but without limitation, by facsimile or email. The Issuer accepts that some methods of communication are not secure and the Paying Agent shall not incur any liability for receiving instructions via any such non-secure method.
The Paying Agent is authorized to comply with and rely upon any such notice, instruction or other communications believed by it to have been sent or given by an authorized person. The Issuer shall use all reasonable endeavours to ensure that
instructions transmitted to the Paying Agent pursuant to this Agreement are complete and correct. Any instructions shall be conclusively deemed to be valid instructions from the Issuer to the Paying Agent for the purposes of this Agreement.

  

	9.	Governing Law and Jurisdiction; Waiver of Jury Trial 

  

	9.1	The interpretation, validity and enforcement of this Agreement, and all legal actions brought under or in connection with the subject matter of this Agreement, shall be governed by the laws of the State of New
York. 

  

	9.2	Any court action brought under or in connection with the subject matter of this Agreement shall be brought only in the United States District Court for the Southern District of New York or, if such court would
not have jurisdiction over the matter, then only in a New York State court sitting in the Borough of Manhattan, City of New York. Each Party submits to the exclusive jurisdiction of these courts and agrees not to commence any legal action under or
in connection with the subject matter of this Agreement in any other court or forum. 

  

	9.3	Each Party waives any objection to the laying of the venue of any legal action brought under or in connection with the subject matter of this Agreement in the Federal or state courts sitting in the Borough of Manhattan,
City of New York, and agrees not to plead or claim in such courts that any such action has been brought in an inconvenient forum. 

  

	9.4	EACH PARTY TO THIS AGREEMENT HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE
TRANSACTION CONTEMPLATED HEREBY. 

  

	10.	U.S. Tax Forms 

  

	10.1	The Paying Agent shall deliver to the Issuer two properly completed and executed originals of IRS Form W-9 (or appropriate successor form) upon entering into this agreement (and from time to time thereafter upon
reasonable request of the Issuer). The Paying Agent agrees that if any form or certification that it previously delivered expires or becomes obsolete or inaccurate in any respect, it shall update such form or certification promptly or promptly
notify the Issuer in writing of its legal inability to do so. 

  

	10.2	The terms of this Section 10 shall survive the termination of this Agreement. 

  
 - 8 - 

	11.	Counterparts 

 This Agreement may be signed in any number of counterparts, each of which
shall be deemed an original. 
  

	12.	Withholding Taxes 

 Notwithstanding any other provision of this Agreement, the Trustee
and Paying Agent shall be entitled to make a deduction or withholding from any payment which it makes under this Agreement for or on account of any present or future taxes, duties or charges if and to the extent so required by any applicable law and
any current or future regulations or agreements thereunder or official interpretations thereof or any law implementing an intergovernmental approach thereto or by virtue of the relevant holder failing to satisfy any certification or other
requirements in respect of the Notes, in which event the Trustee or Paying Agent shall make such payment after such withholding or deduction has been made and shall account to the relevant authorities for the amount so withheld or deducted and shall
have no obligation to gross up any payment hereunder or pay any additional amount as a result of such withholding tax. 

  
 - 9 - 

 In witness whereof, the parties hereto have caused this Agreement to be duly executed as of the
day and year first above written. 
  

					
		 	THERMO FISHER SCIENTIFIC INC., as Issuer
		
	By:	 	 /s/ Anthony H. Smith

		 	Name:	 	Anthony H. Smith
		 	Title:	 	Vice President, Tax and Treasury and Treasurer

  

					
	Paying Agent
	The Bank of New York Mellon, London Branch
		
	By:	 	 /s/ Paul Cattermole

		 	Name:	 	Paul Cattermole
		 	Title:	 	Vice President

 [Signature Page to Paying Agency Agreement]

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