Document:

Protiva 2000 Incentive Stock Option Plan

 Exhibit 4.3 
 PROTIVA BIOTHERAPEUTICS INC. 
  

 
 PROTIVA 2000 INCENTIVE STOCK

 OPTION PLAN 
  

 
 Effective: 

September 30, 2000 

 PROTIVA BIOTHERAPEUTICS INC. 

2000 INCENTIVE STOCK OPTION PLAN 
  

	1.	PURPOSE OF THE PLAN 

 1.1 Purpose of
this Plan. The purpose of this Stock Option Plan is to promote the interests of Protiva Biotherapeutics Inc. by: 
  

	 	(a)	furnishing certain directors, officers, employees or consultants of the Corporation or an Affiliate or other persons as the Compensation Committee may approve with
greater incentive to further develop and promote the business and financial success of the Corporation; 

  

	 	(b)	furthering the identity of interests of persons to whom options may be granted with those of the shareholders of the Corporation generally through share ownership in
the Corporation; and 

  

	 	(c)	assisting the Corporation in attracting, retaining and motivating its directors, officers, employees and consultants. 

The Corporation believes that these purposes may best be effected by granting Options to acquire Common Shares. 

 

	2.	DEFINITIONS 

 2.1 Definitions. In
this Plan, unless there is something in the subject matter or context inconsistent therewith, capitalized words and terms will have the following meanings: 
  

	 	(a)	“Affiliate” means a corporation that is an affiliate of the Corporation under the Securities Act (British Columbia), as amended from time to
time; 

  

	 	(b)	“Board of Directors” means the board of directors of the Corporation as constituted from time to time; 

 

	 	(a)	“Change in Control” means: 

  

	 	(i)	any merger or consolidation in which voting securities of the Corporation possessing more than fifty percent (50%) of the total combined voting power of the
Corporation’s outstanding securities are transferred to a person or persons different from the persons holding those securities immediately prior to such transaction and the composition of the Board of Directors following such transaction is
such that the directors of the Corporation prior to the transaction constitute less than fifty percent (50%) of the Board of Directors membership following the transaction; 

	 	(ii)	any acquisition, directly or indirectly, by an person or related group of persons (other than the Corporation or a person that directly or indirectly controls, is
controlled by, or is under common control with, the Corporation) of beneficial ownership of voting securities of the Corporation possessing more than fifty percent (50%) of the total combined voting power of the Corporation’s outstanding
securities; 

  

	 	(iii)	any acquisition, directly or indirectly, by a person or related group of persons of the right to appoint a majority of the directors of the Corporation or otherwise
directly or indirectly control the management, affairs and business of the Corporation; 

  

	 	(iv)	any sale, transfer or other disposition of all or substantially all of the assets of the Corporation; and 

 

	 	(v)	a complete liquidation or dissolution of the Corporation; 

 provided however, that a Change in Control shall not be deemed to have occurred if such Change in Control results solely from the issuance, in connection with a bona fide financing or series of financings
by the Corporation or any of its Affiliates, of voting securities of the Corporation or any of its Affiliates or any rights to acquire voting securities of the Corporation or any of its Affiliates which are convertible into voting securities;

  

	 	(c)	“Common Shares” means the common shares in the capital of the Corporation as constituted on the Effective Date, provided that if the rights of any
Participant are subsequently adjusted pursuant to Article 9 hereof, “Common Shares” thereafter means the shares or other securities or property which such Participant is entitled to purchase after given effect to such adjustment;

  

	 	(d)	“Compensation Committee” means the committee, as constituted from time to time, which may be appointed by the Board of Directors to, among other
things, interpret, administer and implement the Plan, and includes any successor committee appointed by the Board of Directors for such purposes; 

  

	 	(e)	“Consultant” means any individual, corporation or other person engaged to provide ongoing valuable services to the Corporation or an Affiliate;

  

	 	(f)	“Corporation” means Protiva Biotherapeutics Inc. and includes any successor corporation thereto; 

 

	 	(g)	“Effective Date” has the meaning ascribed thereto by Section 3.1 of this Plan; 

 

	 	(h)	“Eligible Person” means a director, officer, employee or Consultant of the Corporation or an Affiliate or a person otherwise approved by the
Compensation Committee; 

  
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	 	(i)	“Exercise Price” means the price per Common Share at which a Participant may purchase Common Shares pursuant to an Option, provided that if such price
is adjusted pursuant to Section 9.1 hereof, “Exercise Price” thereafter means the price per Common Share at which such Participant may purchase Common Shares pursuant to such Option after giving effect to such adjustment;

  

	 	(j)	“Legal Representative” has the meaning ascribed thereto by Section 6.7 of this Plan; 

 

	 	(k)	“Merger and Acquisition Transaction” means: 

  

	 	(i)	any merger; 

  

	 	(ii)	any acquisition; 

  

	 	(iii)	any amalgamation; 

  

	 	(iv)	any offer for shares of the Corporation which if successful would entitle the offeror to acquire all of the voting securities of the Corporation; or

  

	 	(v)	any arrangement or other scheme of reorganization; 

 that results in a Change in Control; 
  

	 	(l)	“Options” means stock options granted hereunder to purchase Common Shares from treasury pursuant to the terms and conditions hereof and as evidenced by
an Option Agreement and “Option” means any one of them; 

  

	 	(m)	“Option Agreement” means an agreement evidencing an Option, entered into by and between the Corporation and an Eligible Person;

  

	 	(n)	“Outstanding Common Shares” at the time of any share issuance or grant of Options means the number of Common Shares that are outstanding immediately
prior to the share issuance or grant of Options in question, on a fully converted, but non-diluted basis, excluding Common Shares issued pursuant to share compensation arrangements over the preceding one-year period, or such other number as may be
determined under the applicable rules and regulations of all regulatory authorities to which the Corporation is subject, including the Stock Exchange, For the purposes of this definition, fully converted basis means that shares of any series in the
capital of the Corporation outstanding at that time shall be deemed to have been fully converted in accordance with the special rights and restrictions attached thereto into Common Shares in the capital of the Corporation, and the Common Shares
issuable as a result thereof shall be deemed to have been issued and to form part of the holdings of the person(s) entitled to receive such Common Shares; 

  

	 	(o)	“Participant” means a person to whom Options have been granted under this Plan; 

  
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	 	(p)	“Plan” means the Protiva 2000 Incentive Stock Option Plan, as the same may from time to time be supplemented or amended and in effect;

  

	 	(q)	“Shareholders Agreement” means the Shareholders Agreement dated as of August 31, 2001 among the Corporation and certain others, as amended or
replaced from time to time; 

  

	 	(r)	“Stock Exchange” means such stock exchange or other organized market on which the Common Shares are listed or posted for trading;

  

	 	(s)	“U.S. Exchange Act” means the U.S. Securities Exchange Act of 1934, as amended from time to time; 

 

	 	(t)	“U.S. Internal Revenue Code” means the Internal Revenue Code of 1986 of the United States, as amended from time to time; 

 

	 	(u)	“U.S. Nonqualified Stock Option” means an Option to purchase Common Shares other than a U.S. Qualified Incentive Stock Option;

  

	 	(v)	“U.S. Optionee” means a Participant who is a citizen or a resident of the United States (including its territories, possessions and all areas subject
to the jurisdiction); and 

  

	 	(w)	“U.S. Qualified Incentive Stock Option” means an Option to purchase Common Shares with the intention that it qualify as an “incentive stock
option” as that term is defined in Section 422 of the U.S. Internal Revenue Code, such intention being evidenced by the resolutions of the Compensation Committee at the time of grant. 

 

	3.	EFFECTIVE DATE OF PLAN 

 3.1 Effective
Date of this Plan. The effective date (the “Effective Date”) of this Plan is September 30, 2000, the date on which this Plan was deemed to be adopted by the Board of Directors. 

 

	4.	COMMON SHARES SUBJECT TO PLAN 

 4.1
Common Shares Subject to this Plan. The aggregate number of Common Shares in respect of which Options may be granted pursuant to this Plan shall not exceed 1,694,114. The number of Common Shares in respect of which Options may be granted
pursuant to this Plan may be increased, decreased or fixed by the Board of Directors, pursuant to the Shareholders Agreement and as permitted under the applicable rules and regulations of all regulatory authorities to which the Corporation is
subject, including the Stock Exchange. 
 4.2 Regranting of Shares. Upon the expiry, termination or surrender of an Option which has not
been exercised in full, the number of Common Shares reserved for issuance under that Option which have not been issued shall become available for issue for the purpose of additional Options which may be granted under this Plan. 

  
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 4.3 Reservation of Shares. The Board of Directors will reserve for allotment from time to time out of
the authorized but unissued Common Shares sufficient Common Shares to provide for issuance of all Common Shares which are issuable under all outstanding Options. 
 4.4 No Fractional Shares. No fractional Common Shares may be purchased or issued under this Plan. 
  

	5.	ADMINISTRATION OF PLAN 

 5.1
Administration of Plan. The Board of Directors may at any time appoint a committee (the “Compensation Committee”) to administer this Plan on behalf of the Board of Directors in accordance with such terms and conditions as the Board of
Directors may prescribe, consistent with this Plan (provided that if at any such time such a committee has not been appointed by the Board of Directors, this Plan will be administered by the Board of Directors, and in such event references herein to
the Compensation Committee shall be construed to be a reference to the Board of Directors). The Board of Directors will take such steps which in its opinion are required to ensure that the Compensation Committee has the necessary authority to fulfil
its functions under this Plan. 
 5.2 Powers of Compensation Committee. The Compensation Committee is authorized, subject to the
provisions of this Plan, to establish from time to time such rules and regulations, make such determinations and to take such steps in connection with this Plan as in the opinion of the Compensation Committee are necessary or desirable for the
proper administration of this Plan. For greater certainty, without limiting the generality of the foregoing, the Compensation Committee will have the power, where consistent with the general purpose and intent of this Plan and subject to the
specific provisions of this Plan and any approval of the Stock Exchange, if applicable: 
  

	 	(a)	to interpret and construe this Plan and any Option Agreement and to determine all questions arising out of this Plan and any Option Agreement, and any such
interpretation, construction or determination made by the Compensation Committee will be final, binding and conclusive for all purposes; 

  

	 	(b)	to determine to which Eligible Persons Options are granted, and to grant, Options; 

 

	 	(c)	to determine the number of Common Shares covered by each Option; 

  

	 	(d)	to determine the Exercise Price for each Option; 

  

	 	(e)	to determine the time or times when Options will be granted, vest and be exerciseable and to determine when it is appropriate to accelerate when Options otherwise
subject to vesting may be exercised; 

  

	 	(f)	 to determine if the Common Shares that are subject to an Option will be subject to any restrictions or repurchase rights upon the exercise of such
Option including, where applicable, the endorsement of a legend on any certificate representing Common Shares acquired on the exercise of any Option to the effect that such Common Shares may not be offered, sold or delivered except in compliance
with 

  
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the applicable securities laws and regulations of Canada, the United States or any other country and if any rights or restrictions exist they will be described in the applicable option agreement;

  

	 	(g)	to determine the expiration date for each Option and to extend the period of time for which any Option is to remain exerciseable in appropriate circumstances,
including, without limitation, in the event of the Participant’s cessation of service or in the event of a prolonged Corporation-mandated trading restriction period, provided that such date may not be later than the earlier of (A) the date
which is the tenth anniversary of the date on which such Option is granted, and (B) the latest date permitted under the applicable rules and regulations of all regulatory authorities to which the Corporation is subject, including the Stock
Exchange; 

  

	 	(h)	to prescribe the form of the instruments relating to the grant, exercise and other terms of Options; 

 

	 	(i)	to enter into an Option Agreement evidencing each Option which will incorporate such terms as the Compensation Committee in its discretion deems consistent with this
Plan; 

  

	 	(j)	to take such steps and require such documentation from Eligible Persons which in its opinion are necessary or desirable to ensure compliance with the rules and
regulations of the Stock Exchange and all applicable laws; 

  

	 	(k)	to adopt such modifications, procedures and subplans as may be necessary or desirable to comply with the provisions of the laws of Canada, the United States and other
countries in which the Corporation or its Affiliates may operate to ensure the viability and maximization of the benefits from the Options granted to Participants residing in such countries and to meet the objectives of this Plan; and

  

	 	(l)	to determine such other matters as provided for herein.  

  

	6.	GRANT OF OPTIONS 

 Subject
to the rules set out below, the Compensation Committee (or in the case of any proposed Participant who is a member of the Compensation Committee, the Board of Directors) may from time to time grant to any Eligible Person one or more Options as the
Compensation Committee deems appropriate: 
 6.1 Date Option Granted. The date on which an Option will be deemed to have been granted
under this Plan will be the date on which the Compensation Committee authorizes the grant of such Option or such other date as may be specified by the Compensation Committee at the time of such authorization. 

6.2 Number of Common Shares/Maximum Grant. The number of Common Shares that may be purchased under any Option will be determined by the
Compensation Committee, provided that the number of Common Shares reserved for issuance to any one person pursuant to this Plan shall not, in aggregate, exceed 6% of the total number of Outstanding Common Shares. A Participant who holds Options at
the time of granting an Option, may hold more than one Option. 

  
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 6.3 Exercise Price. The Exercise Price per Common Share under each Option will be the fair market
value of such shares at the time of grant, expressed in terms of money, as determined by the Compensation Committee, in its sole discretion, provided that such price may not be less than the lowest price permitted under the applicable rules and
regulations of all regulatory authorities to which the Corporation is subject, including the Stock Exchange. 
 6.4 Option Agreements.
Each Option will be evidenced by an Option Agreement which incorporates such terms and conditions as the Compensation Committee in its discretion deems appropriate and consistent with the provisions of this Plan (and the execution and delivery by
the Corporation of an Option Agreement with a Participant shall be conclusive evidence that such Option Agreement incorporates terms and conditions approved by the Compensation Committee and is consistent with the provisions of this Plan). Each
Option Agreement will be executed by the Participant to whom the Option is granted and on behalf of the Corporation by any member of the Compensation Committee or any officer of the Corporation or such other person as the Compensation Committee may
designate for such purpose. 
 6.5 Term of Options. Each Option will expire on the earlier of: 

 

	 	(a)	the date determined by the Compensation Committee and specified in the Option Agreement pursuant to which such Option is granted, provided that such date may not be
later than the earlier of (A) the date which is the tenth anniversary of the date on which such Option is granted, and (B) the latest date permitted under the applicable rules and regulations of all regulatory authorities to which the
Corporation is subject, including the Stock Exchange; 

  

	 	(b)	in the event the Participant ceases to be an Eligible Person for any reason, other than the death of the Participant or the termination of the Participant for cause,
such period of time after the date on which the Participant ceases to be an Eligible Person as may be specified by the Compensation Committee, which date shall not exceed three months following the termination of the Participant’s employment
with the Corporation or in the case of options granted to a director or Consultant, three months following the Participant ceasing to be a director or a Consultant, unless the Compensation Committee otherwise determines, and which period will be
specified in the Option Agreement with the Participant with respect to such Option; 

  

	 	(c)	in the event of the termination of the Participant as a director, officer, employee or Consultant of the Corporation or an Affiliate for cause, the date of such
termination; 

  

	 	(d)	 in the event of the death of a Participant prior to: (A) the Participant ceasing to be an Eligible Person; or (B) the date which is the
number of days specified by the Compensation Committee pursuant to subparagraph (b) above from the date on which the Participant ceased to be an Eligible Person; the date which is one year

  
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after the date of death of such Participant or such other date as may be specified by the Compensation Committee and which period will be specified in the Option Agreement with the Participant
with respect to such Option; and 

  

	 	(e)	notwithstanding the foregoing provisions of subparagraphs (b), (c) and (d) of this Section 6.5, the Compensation Committee may, subject to regulatory
approval, at any time prior to expiry of an Option extend the period of time within which an Option may be exercised by a Participant who has ceased to be an Eligible Person, but such an extension shall not be granted beyond the original expiry date
of the Option as provided for in subparagraph (a) above. 

 Notwithstanding the foregoing, except as expressly permitted by
the Compensation Committee, all Options will cease to vest as at the date upon which the Participant ceases to be an Eligible Person. 
 6.6
Change in Status. A change in the status, office, position or duties of a Participant from the status, office, position or duties held by such Participant on the date on which the Option was granted to such Participant will not result in the
termination of the Option granted to such Participant provided that such Participant remains a director, officer, employee or Consultant of the Corporation or an Affiliate. 
 6.7 Non-Transferability of Options. Each Option Agreement will provide that the Option granted thereunder is not transferable or assignable and may be exercised only by the Participant or, in the
event of the death of the Participant or the appointment of a committee or duly appointed attorney of the Participant or of the estate of the Participant on the grounds that the Participant is incapable, by reason of physical or mental infirmity, of
managing their affairs, the Participant’s legal representative or such committee or attorney, as the case may be (the “Legal Representative”). 
 6.8 Representations and Covenants of Participants. Each Option Agreement will contain representations and covenants of the Participant that: 

 

	 	(a)	the Participant is a director, officer, employee, or Consultant of the Corporation or an Affiliate or a person otherwise approved as an “Eligible Person”
under this Plan by the Compensation Committee; 

  

	 	(b)	the Participant has not been induced to enter into such Option Agreement by the expectation of employment or continued employment with the Corporation or an Affiliate;

  

	 	(c)	the Participant is aware that the grant of the Option and the issuance by the Corporation of Common Shares thereunder are exempt from the obligation under applicable
securities laws to file a prospectus or other registration document qualifying the distribution of the Options or the Common Shares to be distributed thereunder under any applicable securities laws; 

 

	 	(d)	 upon each exercise of an Option, the Participant, or the Legal Representative of the Participant, as the case may be, will, if requested by the
Corporation, represent 

  
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and agree in writing that the person is, or the Participant was, a director, officer, employee or Consultant of the Corporation or an Affiliate or a person otherwise approved as an “Eligible
Person” under this Plan by the Compensation Committee and has not been induced to purchase the Common Shares by expectation of employment or continued employment with the Corporation or an Affiliate, and that such person is not aware of any
commission or other remuneration having been paid or given to others in respect of the trade in the Common Shares; and 

  

	 	(e)	if the Participant or the Legal Representative of the Participant exercises the Option, the Participant or the Legal Representative, as the case may be, will prior to
and upon any sale or disposition of any Common Shares purchased pursuant to the exercise of the Option, comply with all applicable securities laws and all applicable rules and regulations of all regulatory authorities to which the Corporation is
subject, including the Stock Exchange, and will not offer, sell or deliver any of such Common Shares, directly or indirectly, in the United States or to any citizen or resident of, or any Corporation, partnership or other entity created or organized
in or under the laws of, the United States, or any estate or trust the income of which is subject to United States federal income taxation regardless of its source, except in compliance with the securities laws of the United States.

 6.9 Provisions Relating to Share Issuances. Each Option Agreement will contain such provisions as in the opinion of the
Compensation Committee are required to ensure that no Common Shares are issued on the exercise of an Option unless the Compensation Committee is satisfied that the issuance of such Common Shares will be exempt from all registration or qualification
requirements of applicable securities laws and will be permitted under the applicable rules and regulations of all regulatory authorities to which the Corporation is subject, including the Stock Exchange. In particular, if required by any regulatory
authority to which the Corporation is subject, including the Stock Exchange, an Option Agreement may provide that shareholder approval to the grant of an Option must be obtained prior to the exercise of the Option or to the amendment of the Option
Agreement. 
  

	7.	U.S. QUALIFIED INCENTIVE STOCK OPTION PROVISIONS 

 To the extent required by Section 422 of the U.S. Internal Revenue Code, U.S. Qualified Incentive Stock Options shall be subject to the following additional terms and conditions and if there is any
conflict between the terms of this Article and other provisions under this Plan, the provisions under this Article shall prevail: 
 7.1
Eligible Employees. All classes of employees of the Corporation or one of its parent corporations or subsidiary corporations may be granted U.S. Qualified Incentive Stock Options. U.S. Qualified Incentive Stock Options shall only be granted
to U.S. Optionees who are, at the time of grant, officers, key employees or directors of the Corporation or one of its parent corporations or subsidiary corporations (provided, for purposes of this Article 7 only, such directors are then also
officers or key employees of the Corporation or one of its parent corporations or subsidiary corporations). For purposes of this Article 7, “parent corporation” and “subsidiary corporation” shall have the meanings attributed to
those terms for the purposes of 

  
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Section 422 of the U.S. Internal Revenue Code. Any director of the Corporation who is a U.S. Optionee shall be ineligible to vote upon the granting of such Option; and for greater certainty,
contractors of the Corporation or subsidiary corporations may not be granted U.S. Qualified Incentive Stock Options. 
 7.2 Dollar
Limitation. To the extent the aggregate fair market value (determined as of the grant date) of Common Shares with respect to which U.S. Qualified Incentive Stock Options are exercisable for the first time by a U.S. Optionee during any calendar
year (under this Plan and all other stock option plans of the Corporation) exceeds U.S. $100,000, such portion in excess of U.S. $100,000 shall be treated as a U.S. Nonqualified Stock Option. In the event the U.S. Optionee holds two or more such
Options that become exercisable for the first time in the same calendar year, such limitation shall be applied on the basis of the order in which such Options are granted. 
 7.3 10% Shareholders. If any U.S. Optionee to whom an U.S. Qualified Incentive Stock Option is to be granted under this Plan at the time of the grant of such U.S. Qualified Incentive Stock
Option is the owner of shares possessing more than ten percent (10%) of the total combined voting power of all classes of shares of the Corporation, then the following special provisions shall be applicable to the U.S. Qualified Incentive Stock
Option granted to such individual: 
  

	 	(i)	the Exercise Price (per Common Share) subject to such U.S. Qualified Incentive Stock Option shall not be less than one hundred ten percent (110%) of the fair
market value of one Common Share at the time of grant; and 

  

	 	(ii)	for the purposes of this Article 7 only, the option exercise period shall not exceed five (5) years from the date of grant. 

The determination of 10% ownership shall be made in accordance with Section 422 of the U.S. Internal Revenue Code. 

7.4 Exercisability. To qualify for U.S. Qualified Incentive Stock Option tax treatment, an Option designated as a U.S. Qualified Incentive
Stock Option must be exercised within three months after termination of employment for reasons other than death, except that, in the case of termination of employment due to total disability, such Option must be exercised within one year after such
termination. Employment shall not be deemed to continue beyond the first 90 days of a leave of absence unless the U.S. Optionee’s reemployment rights are guaranteed by statute or contract. For purposes of this Section 7.4, “total
disability” shall mean a mental or physical impairment of the U.S. Optionee which is expected to result in death or which has lasted or is expected to last for a continuous period of 12 months or more and which causes the U.S. Optionee to be
unable, in the opinion of the Corporation and two independent physicians, to perform his or her duties for the Corporation and to be engaged in any substantial gainful activity. Total disability shall be deemed to have occurred on the first day
after the Corporation and the two independent physicians have furnished their opinion of total disability to the Compensation Committee. 

  
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 7.5 Taxation of U.S. Qualified Incentive Stock Options. In order to obtain
certain tax benefits afforded to U.S. Qualified Incentive Stock Options under Section 422 of the U.S. Internal Revenue Code, the U.S. Optionee must hold the Common Shares issued upon the exercise of a U.S. Qualified Incentive Stock Option for
two years after the date of grant of the U.S. Qualified Incentive Stock Option and one year from the date of exercise. A U.S. Optionee may be subject to U.S. alternative minimum tax at the time of exercise of a U.S. Qualified Incentive Stock Option.
The Compensation Committee may require a U.S. Optionee to give the Corporation prompt notice of any disposition of shares acquired by the exercise of a U.S. Qualified Incentive Stock Option prior to the expiration of such holding periods.

 7.6 Transferability. No U.S. Qualified Incentive Stock Option granted under this Plan may be assigned or transferred by the U.S.
Optionee other than by will or by the laws of descent and distribution, and during the U.S. Optionee’s lifetime, such U.S. Qualified Incentive Stock Option may be exercised only by the U.S. Optionee. 

7.7 Compensation Committee Governance if U.S. Registrant. If and so long as the Common Shares are registered under Section 12(b) or
12(g) of the U.S. Securities Exchange Act, the Board of Directors will consider in selecting the members of the Compensation Committee, with respect to any persons subject or likely to become subject to Section 16 of the U.S. Securities
Exchange Act, the provisions regarding “nonemployee directors” as contemplated by Rule 16b-3 under the U.S. Securities Exchange Act. 

7.8 Exercise Price. Notwithstanding Section 6.3, no U.S. Qualified Incentive Stock Option granted under the Plan shall have an Exercise Price
less than the fair market value of the underlying Common Shares at the date of grant of such Option, as determined at such time in good faith by the Board or Directors or the Compensation Committee, as the case may be. 

7.9 Approval by Shareholders. No U.S. Qualified Incentive Stock Option granted to a U.S. Optionee under this Plan shall become exercisable unless
and until this Plan shall have been approved by the shareholders of the Corporation within 12 months of approval by the Board of Directors of the Corporation. 
 7.10 Option Agreements. Each Option will be evidenced by an Option Agreement which incorporates such terms and conditions as the Compensation Committee in its discretion deems appropriate and
consistent with the provisions of this Plan (and the execution and delivery by the Corporation of an Option Agreement with a Participant shall be conclusive evidence that such Option Agreement incorporates terms and conditions approved by the
Compensation Committee and is consistent with the provisions of this Plan). Each Option Agreement will be executed by the Participant to whom the Option is granted and on behalf of the Corporation by any member of the Compensation Committee or any
officer of the Corporation or such other person as the Compensation Committee may designate for such purpose. Each option agreement will specify the reasons for the Corporation granting options to such participant. 

 

	8.	EXERCISE OF OPTIONS 

 8.1 Exercise of
Options. Subject to the terms and conditions of this Plan, the Compensation Committee may impose such limitations or conditions on the exercise or vesting 

  
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of any Option as the Compensation Committee in its discretion deems appropriate, including limiting the number of Common Shares for which any Option may be exercised during any period as may be
specified by the Compensation Committee and which number of Common Shares for which such Option may be exercised in any period will be specified in the Option Agreement with respect to such Option. Each Option Agreement will provide that the Option
granted thereunder may be exercised only by notice signed by the Participant or the Legal Representative of the Participant and accompanied by full payment for the Common Shares being purchased. Such consideration may be paid in any combination of
the following: 
  

	 	(a)	cash, bank draft or certified cheque; 

  

	 	(b)	delivery of a properly executed exercise notice, together with irrevocable instructions, to (i) a brokerage firm designated by the Company to deliver promptly to
the Company the aggregate amount of sale or loan proceeds to pay the aggregate Exercise Price and any withholding tax obligations that may arise in connection with the exercise, and (ii) the Company to deliver the certificates for such
purchased shares directly to such brokerage firm, all in accordance with the regulations of any relevant regulatory authorities; or 

  

	 	(c)	such other consideration as the Compensation Committee may permit consistent with applicable laws. 

As soon as practicable after any exercise of an Option, a certificate or certificates representing the Common Shares in respect of which such Option is
exercised will be delivered by the Corporation to the Participant. 
 8.2 Withholding Tax. The Participant will be solely responsible for
paying any applicable withholding taxes arising from the grant, vesting or exercise of any Option and payment is to be made in a manner satisfactory to the Corporation. Notwithstanding the foregoing, the Corporation will have the right to withhold
from any Option or any Common Shares issuable pursuant to an Option or from any cash amounts otherwise due or to become due from the Corporation to the Participant, an amount equal to any such taxes. 

8.3 Conditions. Notwithstanding any of the provisions contained in this Plan or in any Option Agreement, the Corporation’s obligation to
issue Common Shares to a Participant pursuant to the exercise of an Option will be subject to, if applicable: 
  

	 	(a)	completion of such registration or other qualification of such Common Shares or obtaining approval of such governmental authority as the Corporation will determine to
be necessary or advisable in connection with the authorization, issuance or sale thereof; 

  

	 	(b)	the admission of such Common Shares to listing or quotation on the Stock Exchange; and 

 

	 	(c)	the receipt from the Participant of such representations, agreements and undertakings, including as to future dealings in such Common Shares, as the Company or its
counsel determines to be necessary or advisable in order to safeguard against the violation of the securities laws of any jurisdiction. 

  
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	9.	SUSPENSION, AMENDMENT OR TERMINATION OF PLAN 

 9.1 Suspension, Amendment or Termination of Plan. This Plan will terminate on the tenth anniversary of the Effective Date. The Compensation Committee will have the right at any time to suspend,
amend or terminate this Plan in any manner including, without limitation, to reflect any requirements of any regulatory authorities to which the Corporation is subject, including the Stock Exchange, and on behalf of the Corporation agree to any
amendment to any Option Agreement provided that the Compensation Committee in its discretion deems such amendment consistent with the terms of this Plan and all procedures and necessary approvals required under the applicable rules and regulations
of all regulatory authorities to which the Corporation is subject are complied with and obtained, but the Compensation Committee will not have the right to: 
  

	 	(a)	affect in a manner that is adverse or prejudicial to, or that impairs, the benefits and rights of any Participant under any Option previously granted under this Plan
(except as permitted pursuant to Article 10 and except for the purpose of complying with applicable securities laws or the bylaws, rules and regulations of any regulatory authority to which the Corporation is subject, including the Stock Exchange);

  

	 	(b)	decrease the number of Common Shares which may be purchased pursuant to any Option (except as permitted pursuant to Article 10) without the consent of such Participant;

  

	 	(c)	increase the Exercise Price at which Common Shares may be purchased pursuant to any Option (except as permitted pursuant to Article 10) without the consent of such
Participant; 

  

	 	(d)	extend the term of any Option beyond a period of ten years or the latest date permitted under the applicable rules and regulations of all regulatory authorities to
which the Corporation is subject, including the Stock Exchange; 

  

	 	(e)	grant any Option if this Plan is suspended or has been terminated; or 

  

	 	(f)	change or adjust any outstanding U.S. Qualified Incentive Stock Option without the consent of the Participant if such change or adjustment would constitute a
“modification” that would cause such U.S. Qualified Incentive Stock Option to fail to continue to qualify as a U.S. Qualified Incentive Stock Option. 

 9.2 Powers of Compensation Committee Survive Termination. The full powers of the Compensation Committee as provided for in this Plan will survive the termination of this Plan until all Options have
been exercised in full or have otherwise expired. 

  
 13 

	10.	ADJUSTMENTS 

 10.1 Adjustments.
Appropriate adjustments in the number of Common Shares subject to this Plan, as regards Options granted or to be granted, in the number of Common Shares optioned and the applicable Exercise Price will be conclusively determined by the
Compensation Committee to give effect to adjustments in the number of Common Shares resulting from subdivisions, consolidations, substitutions, or reclassifications of the Common Shares, the payment of stock dividends by the Corporation (other than
dividends in the ordinary course) or other relevant changes in the capital of the Corporation or from a proposed merger, amalgamation or other corporate arrangement or reorganization involving the exchange or replacement of Common Shares of the
Corporation for those in another corporation. Any dispute that arises at any time with respect to any such adjustment will be conclusively determined by the Compensation Committee, and any such determination will be binding on the Corporation, the
Participant and all other affected parties. 
 10.2 Merger and Acquisition Transaction. In the event of a Merger and Acquisition
Transaction or proposed Merger and Acquisition Transaction, the Compensation Committee, at its option, may do any of the following: 
  

	 	(a)	the Compensation Committee may, in a fair and equitable manner, determine the manner in which all unexercised option rights granted under this Plan will be treated
including, without limitation, requiring the acceleration of the time for the exercise of such rights by the Participants, the time for the fulfilment of any conditions or restrictions on such exercise, and the time for the expiry of such rights; or

  

	 	(b)	the Compensation Committee or any corporation which is or would be the successor to the Corporation or which may issue securities in exchange for Common Shares upon the
Merger and Acquisition Transaction becoming effective may offer any Participant the opportunity to obtain a new or replacement option over any securities into which the Common Shares are changed or are convertible or exchangeable, on a basis
proportionate to the number of Common Shares under option and the Exercise Price (and otherwise substantially upon the terms of the Option being replaced, or upon terms no less favourable to the Participant) including, without limitation, the
periods during which the Option may be exercised and expiry dates; and in such event, the Participant shall, if he accepts such offer, be deemed to have released his Option over the Common Shares and such Option shall be deemed to have lapsed and be
cancelled; or 

  

	 	(c)	the Compensation Committee may commute for or into any other security or any other property or cash, any Option that is still capable of being exercised, upon giving to
the Participant to whom such Option has been granted at least 30 days written notice of its intention to commute such Option, and during such period of notice, the Option, to the extent it has not been exercised, may be exercised by the Participant
without regard to any vesting conditions attached thereto; and on the expiry of such period of notice, the unexercised portion of the Option shall lapse and be cancelled. 

  
 14 

 Section 10.1 and subsections (a), (b) and (c) of this Section 10.2 are intended to be
permissive and may be utilized independently or successively in combination or otherwise, and nothing therein contained shall be construed as limiting or affecting the ability of the Compensation Committee to deal with Options in any other manner.
All determinations by the Compensation Committee under this Section will be final, binding and conclusive for all purposes. 
 10.3
Limitations. The grant of Options under this Plan will in no way affect the Corporation’s right to adjust, reclassify, reorganize or otherwise change its capital or business structure or to merge, amalgamate, reorganize, consolidate,
dissolve, liquidate or sell or transfer all or any part of its business or assets or engage in any like transaction. 
 10.4 No
Fractional Shares. No adjustment or substitution provided for in this Article 10 will require the Corporation to issue a fractional share in respect of any Option and the total substitution or adjustment with respect to each Option will be
limited accordingly. 
  

	11.	GENERAL 

 11.1 No Rights as
Shareholder. Nothing herein or otherwise shall be construed so as to confer on any Participant any rights as a shareholder of the Corporation with respect to any Common Shares reserved for the purpose of any Option. 

11.2 No Effect on Employment. Nothing in this Plan or any Option Agreement will confer upon any Participant any right to continue in the employ of
or under contract with the Corporation or an Affiliate or affect in any way the right of the Corporation or any such Affiliate to terminate his or her employment at any time or terminate his or her consulting contract; nor will anything in this Plan
or any Option Agreement be deemed or construed to constitute an agreement, or an expression of intent, on the part of the Corporation or any such Affiliate to extend the employment of any Participant beyond the time that he or she would normally be
retired pursuant to the provisions of any present or future retirement plan of the Corporation or an Affiliate or any present or future retirement policy of the Corporation or an Affiliate, or beyond the time at which he or she would otherwise be
retired pursuant to the provisions of any contract of employment with the Corporation or an Affiliate. Neither any period of notice nor any payment in lieu thereof upon termination of employment shall be considered as extending the period of
employment for the purposes of the Plan. 
 11.3 No Fettering of Directors’ Discretion. Nothing contained in this Plan will
restrict or limit or be deemed to restrict or limit the right or power of the Board of Directors in connection with any allotment and issuance of Common Shares which are not allotted and issued under this Plan including, without limitation, with
respect to other compensation arrangements. 
 11.4 Applicable Law. The Plan and any Option Agreement granted hereunder will be
governed, construed and administered in accordance with the laws of the Province of British Columbia and the laws of Canada applicable therein. 
 11.5 Interpretation. References herein to any gender include all genders and to the plural includes the singular and vice versa. The division of this Plan into Sections and Articles and the
insertion of headings are for convenience of reference only and will not affect the construction or interpretation of this Plan. 

  
 15 

 11.6 Reference. This Plan may be referred to as the “Protiva 2000 Incentive Stock Option
Plan”. 

  
 16Form of Director Restricted Stock Award

 Exhibit 10.1 
 DIRECTOR 
 RESTRICTED STOCK AWARD 

UNDER THE PROVISIONS OF THE 
 CYRUSONE 2012 LONG TERM INCENTIVE PLAN 
  

			
	Name of Director:	  	[Director Name]
	Award Date:	  	[Award Date]
	Number of Restricted Shares:	  	[Number of Shares]

 Pursuant to the provisions of the CyrusOne 2012 Long Term Incentive Plan, as in effect on the date noted
above (the “Award Date”) and as it may thereafter be amended (the “Plan”), a copy of which has been delivered to the director named above (“you” or the “Director”), the Board of
Directors of CyrusOne Inc. (the “Board”) hereby grants you an award of [—] common shares, par value $.01 per share, of CyrusOne Inc. (the “Shares”), on and subject
to the terms of the Plan and your agreement to the following terms, conditions and restrictions. Capitalized terms used in this restricted stock award agreement (this “Agreement”) that are not defined in this Agreement have the
meanings as used or defined in the Plan. 
 1. Securities Subject to this Agreement. This Agreement is made with respect
to the Shares and any securities (including Shares of CyrusOne Inc. (“CyrusOne”)) issued in respect of the Shares, whether by way of a share dividend, a share split, any reorganization or re-capitalization of CyrusOne or its stock
or any merger, exchange of securities or like event or transaction as the result of which any security or securities of any kind are issued to you by reason of your ownership of the Shares. Any such securities issued in respect of any of the Shares
shall be subject to the same restrictions, terms and conditions set forth in this Agreement, and shall be administered in the same manner, as the Shares to which they relate. References in the following terms of this Agreement to the Shares shall
include any such securities issued in respect of the Shares. 
 2. Rights of Ownership. Except for the Restrictions (as
defined in Section 6 hereof), you are the record and beneficial owner of the Shares, with all rights and privileges (including but not limited to the right to vote, to receive dividends and to receive distributions upon liquidation of CyrusOne)
appertaining thereto. Prior to the date on which your rights with respect to a Share have become vested and the Restrictions have lapsed as provided in Section 3, 4 or 5 hereof, you shall be entitled to exercise voting rights with respect to
such Share and shall be entitled to receive dividends or other distributions with respect thereto. 
 3. Termination of
Restrictions Upon Passage of Time. The Restrictions shall lapse and thereby terminate and be of no further force or effect by reason of or in relation to the passage of time in accordance with and to the extent provided under the terms of
paragraphs (a), (b) and (c) of this Section 3, except as otherwise determined by the Board in its sole discretion or as otherwise provided in Section 4 or 5 hereof. 

(a) If you are still a Director on May 15, 2014, then on such date the Restrictions shall lapse and thereby terminate
as to 1/3 (one-third) of the Shares. 
 (b) If you are still a Director on the second anniversary of the Award
Date, then on such date the Restrictions shall lapse and thereby terminate as to an additional 1/3 (one-third) of the Shares. 

 (c) If you are still a Director on the third anniversary of the Award Date,
then on such date the Restrictions shall lapse and thereby terminate as to the remaining 1/3 (one-third) of the Shares. 
 4.
Termination of Service. Unless the Board determines otherwise, if you shall cease to be a Director for any reason other than by reason of your voluntary resignation, then, effective as of the date of such termination of service, the
Restrictions (to the extent the Restrictions have not earlier terminated under the terms of this Agreement) shall lapse and thereby terminate and be of no further force or effect with respect to all of the Shares. 

5. Termination of Restrictions Upon Change in Control. If a Change in Control occurs, then, notwithstanding Section 17 of the
Plan, effective as of the date of such Change in Control, the Restrictions (to the extent the Restrictions have not earlier terminated under the terms of this Agreement) shall lapse and thereby terminate and be of no further force or effect with
respect to all of the Shares. 
 6. Forfeiture. The Shares and any interest therein shall be subject to the forfeiture and
transfer restrictions as described in this Section 6 (the “Restrictions”). Except as otherwise determined by the Board or provided in Sections 4 and 5 hereof, any Shares that remain subject to the Restrictions on the date you
cease to be a Director shall be forfeited to CyrusOne as of such date and, upon such forfeiture, all of your rights in respect of such Shares shall cease automatically and without further action by CyrusOne or you. In addition, except as otherwise
determined by the Board or provided in Section 16 of the Plan, any Shares that remain subject to Restrictions may not be transferred, sold, assigned alienated, transferred, pledged, attached, conveyed or otherwise encumbered by you in any
manner whatsoever and whether or not for consideration. For the purpose of giving effect to this provision, you must execute and deliver to CyrusOne a stock power with respect to each certificate evidencing any of the Shares, thereby assigning to
CyrusOne all of your interest in the Shares. By the execution and delivery of this Agreement, you authorize and empower CyrusOne, in the event of a forfeiture of any of the Shares under this Section 6 to (i) date (as of the date you cease
to be a Director) those stock powers relating to Shares that remain subject to the Restrictions as of the date you cease to be a Director and (ii) present such stock powers and the certificates to which they relate to CyrusOne’s transfer
agent or other appropriate party for the sole purpose of transferring the forfeited Shares to CyrusOne. 
 7. Matters
Relating to Certificates. 
 (a) On or following the date of this Agreement, any Shares issued to you in
accordance with and subject to this Agreement shall be evidenced in such manner as CyrusOne shall determine. 

(b) Each certificate or book entry credit issued or entered in respect of any Shares issued to you in accordance with this
Agreement shall bear the following legend: 
 “The Shares evidenced by this certificate are subject to the terms of a
Restricted Stock Agreement between the registered holder hereof and CyrusOne Inc., dated as of [Award Date], and may not be transferred by the holder, except as provided by the terms of such agreement, a copy of which is on deposit with the

  
 2 

 
Secretary of CyrusOne Inc. and which will be mailed to a shareholder of CyrusOne Inc. without charge within five days after receipt of a written request.” 

(c) CyrusOne shall require that the certificates or book entry credits evidencing title of the Shares be held in custody
by CyrusOne until such time, if any, as your rights with respect to the Shares have vested, and CyrusOne may require that, as a condition of your receiving the Shares you shall have delivered to CyrusOne a stock power, endorsed in blank, relating to
such Shares. To the extent that your rights with respect to the Shares become vested, the legend set forth above shall be removed from the certificates or book entry credits evidencing such Shares. 

8. Interpretation. You acknowledge that the Board has the authority to construe and interpret the terms of the Plan and this
Agreement if and when any questions of meaning arises under the Plan or this Agreement, and any such construction or interpretation shall be binding on you, your heirs, executors, administrators, personal representatives and any other persons having
or claiming to have an interest in the Shares. 
 9. Withholding. In the event that the award and receipt of the Shares,
the expiration of the Restrictions, the payment of dividends on the Shares or any other event results in your realization of income or wages which for federal, state and/or local income or other employment tax purposes is, in the opinion of the
Company, subject to withholding of tax by the Company, you shall pay to the Company an amount equal to the withholding tax amount that the Company determines applies with respect to such event or make arrangements satisfactory to the Company
regarding the payment of such tax, which arrangements may include your agreement to surrender the Shares that have become free of the Restrictions. Otherwise, the Company may, at its discretion and to the extent it determines is necessary to pay
such withholding tax amount, withhold any such withholding tax amount from your salary, dividends paid by CyrusOne on Shares, any Shares that have become free of Restrictions or any other compensation payable to you. 

10. Notices. All notices and other communications to be given hereunder shall be in writing and shall be deemed to have been duly
given when delivered personally or when deposited in the United States mail, first class postage prepaid, and addressed as follows: 
  

			
	 TO CYRUSONE:
	    	CyrusOne Inc.
		    	Kimberly Sheehy
		    	1649 Frankford Road
		    	Carrollton, TX 75007
		
	 TO THE DIRECTOR:
	    	Director Name
		    	Address

 or to any other address as to which notice has been given in the manner herein provided. 

11. Effect of Other Arrangements. In the event of any conflict between the terms of the Plan, on the one hand, and the terms of
this Agreement, on the other hand, the terms of the Plan shall govern. 

  
 3 

 12. Miscellaneous. 

(a) This Agreement shall be binding upon the parties hereto and their respective heirs, executors, administrators,
personal representatives, successors and assigns. Subject to the provisions of the Plan, this Agreement constitutes the entire agreement between the parties with respect to the subject matter hereof and shall be construed and interpreted in
accordance with the laws of the State of Texas. If any provisions of this Agreement shall be deemed to be invalid or void under any applicable law, the remaining provisions hereof shall not be affected thereby and shall continue in full force and
effect. 
 (b) The Board may waive any conditions or rights under, amend any terms of, or alter, suspend,
discontinue, cancel or terminate this Agreement prospectively or retroactively; provided, however, that any such waiver, amendment, alteration, suspension, discontinuance, cancelation or termination that would materially and adversely impair your
rights hereunder shall not to that extent be effective without your consent (it being understood, notwithstanding the foregoing proviso, that this Agreement and the Shares shall be subject to the provisions of Sections 17 and 18 of the Plan).

 (c) All disputes, controversies and claims arising between you and CyrusOne concerning the subject matter of
this Agreement or the Plan shall be settled by arbitration in accordance with the rules and procedures of the American Arbitration Association in effect at the time that the arbitration begins, to the extent not inconsistent with this Agreement or
the Plan. The location of the arbitration shall be Dallas, Texas or such other place as the parties to the dispute may mutually agree. In rendering any award or ruling, the arbitrator or arbitrators shall determine the rights and obligations of the
parties according to the substantive and procedural laws of the State of Texas. The arbitration shall be conducted by an arbitrator selected in accordance with the aforesaid arbitration procedures. Any arbitration pursuant to this Section 12(c)
shall be final and binding on the parties, and judgment upon any award rendered in such arbitration may be entered in any court, Federal or state, having jurisdiction. The parties to any dispute shall each pay their own costs and expenses (including
arbitration fees and attorneys’ fees) incurred in connection with arbitration proceedings and the fees of the arbitrator shall be paid in equal amounts by the parties. Nothing in this Section 12(c) shall preclude you or CyrusOne from
seeking temporary injunctive relief from any Federal or state court located within the State of Texas in connection with or as a supplement to an arbitration hereunder. 

(d) This Agreement may be executed in any number of counterparts, each of which shall be deemed an original. The
counterparts shall constitute one and the same instrument, which shall be sufficiently evidenced by any one thereof. Headings used throughout this Agreement are for convenience only and shall not be given legal significance. Whenever the words
“include”, “includes” or “including” are used in this Agreement, they shall be deemed to be followed by the words “but not limited to”. The term “or” is not exclusive. 

  
 4 

 Please indicate your acceptance by signing at the place provided and returning this Agreement. 

 

									
		 		 		 	CYRUSONE INC.
					
	Dated:	 	 [Award Date]
	 		 	By:	 	  

		 		 		 	[Name]	 	
		 		 		 	[Title]	 	
				
		 		 		 	[Director]:
				
	Dated:	 	  
	 		 	  

		 		 		 	Accepted and Agreed

  
 5

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