Document:

EX-10.2

 Exhibit 10.2 

BRIDGE LOAN AGREEMENT 

dated as of March 15, 2020 

between 
 PROGENICS
PHARMACEUTICALS, INC., 
 as Borrower 

and 
 LANTHEUS MEDICAL
IMAGING, INC., 
 as Lender 

 TABLE OF CONTENTS 

 

							
	 	  	 	  	Page	 
	 ARTICLE I DEFINITIONS; CONSTRUCTION
	  	 	1	 
			
	 Section 1.1
	  	Definitions	  	 	1	 
	 Section 1.2
	  	Other Definitional Provisions	  	 	7	 
	 Section 1.3
	  	Accounting Terms and Principles	  	 	7	 
		
	 ARTICLE II AMOUNT AND TERMS OF THE LOAN
	  	 	7	 
			
	 Section 2.1
	  	Loan Amount	  	 	7	 
	 Section 2.2
	  	Borrowing Procedure	  	 	7	 
	 Section 2.3
	  	Funding	  	 	7	 
	 Section 2.4
	  	Repayment of Loan	  	 	7	 
	 Section 2.5
	  	Optional and Mandatory Prepayments	  	 	8	 
	 Section 2.6
	  	Interest on the Loan	  	 	8	 
	 Section 2.7
	  	Computation of Interest	  	 	8	 
	 Section 2.8
	  	Evidence of Debt	  	 	8	 
	 Section 2.9
	  	Payments Generally	  	 	8	 
	 Section 2.10
	  	Taxes	  	 	9	 
	 Section 2.11
	  	Illegality	  	 	12	 
		
	 ARTICLE III CONDITIONS PRECEDENT TO THE LOAN
	  	 	12	 
			
	 Section 3.1
	  	Conditions to Closing	  	 	12	 
	 Section 3.2
	  	Conditions Precedent to Making the Loan	  	 	12	 
		
	 ARTICLE IV REPRESENTATIONS AND WARRANTIES
	  	 	13	 
			
	 Section 4.1
	  	Corporate Existence	  	 	13	 
	 Section 4.2
	  	Power; Authorization; Enforceable Obligations	  	 	13	 
	 Section 4.3
	  	No Legal Bar	  	 	14	 
	 Section 4.4
	  	No Material Litigation: No MIPI Borrower Affiliate Indebtedness	  	 	14	 
	 Section 4.5
	  	No Default	  	 	14	 
	 Section 4.6
	  	Solvency	  	 	14	 
		
	 ARTICLE V COVENANTS
	  	 	14	 
			
	 Section 5.1
	  	Delivery of Financial Information	  	 	14	 
	 Section 5.2
	  	Notice of Default	  	 	14	 
	 Section 5.3
	  	Compliance with Merger Agreement Covenants	  	 	15	 
	 Section 5.4
	  	Use of Proceeds	  	 	15	 
	 Section 5.5
	  	Debt Financing	  	 	15	 
		
	 ARTICLE VI EVENTS OF DEFAULT
	  	 	16	 
			
	 Section 6.1
	  	Events of Default	  	 	16	 
	 Section 6.2
	  	Remedies	  	 	17	 
		
	 ARTICLE VII MISCELLANEOUS
	  	 	17	 
			
	 Section 7.1
	  	Notices	  	 	17	 

  
 i 

 TABLE OF CONTENTS 

(continued) 
  

							
	 	  	 	  	Page	 
	 Section 7.2
	  	Waiver; Amendments	  	 	19	 
	 Section 7.3
	  	Expenses; Indemnification	  	 	19	 
	 Section 7.4
	  	Successors and Assigns	  	 	19	 
	 Section 7.5
	  	Governing Law; Consent to Jurisdiction; Waiver of Jury Trial	  	 	20	 
	 Section 7.6
	  	Counterparts; Integration	  	 	20	 
	 Section 7.7
	  	Survival	  	 	20	 
	 Section 7.8
	  	Severability	  	 	21	 

  
 ii 

 BRIDGE LOAN AGREEMENT 

THIS BRIDGE LOAN AGREEMENT (as amended, restated or otherwise modified from time to time, this “Agreement”) is made and
entered into as of March 15, 2020 by and between PROGENICS PHARMACEUTICALS, INC., a Delaware corporation (the “Borrower”) and LANTHEUS MEDICAL IMAGING, INC., a Delaware corporation (the “Lender”). 

W I T N E S S E T H: 

WHEREAS, in connection with the Merger Agreement (as defined below) and the transactions contemplated thereby, the Borrower has requested that
the Lender provide for a secured bridge loan facility in an aggregate principal amount of up to Ten Million Dollars ($10,000,000); and 

WHEREAS, subject to the terms and conditions of this Agreement, the Lender is willing to make the requested loan to the Borrower. 

NOW, THEREFORE, in consideration of the premises and the mutual covenants herein contained, the Borrower and the Lender agree as follows: 

ARTICLE I 

DEFINITIONS; CONSTRUCTION 

Section 1.1    Definitions. The following terms used
herein shall have the meanings herein specified (to be equally applicable to both the singular and plural forms of the terms defined): 

“Agreement” shall have the meaning assigned to such term in the opening paragraph of this Agreement. 

“Availability Period” means the period commencing on May 1, 2020 and ending on the earlier the Funding Date and the
Maturity Date; provided that, if prior thereto, the Availability Period shall end upon the termination of the Lender’s obligations pursuant to Section 6.2. 

“Borrower shall have the meaning assigned to such term in the opening paragraph of this Agreement. 

“Borrower Affiliate” means the Borrower and each Subsidiary thereof. 

“Business Day” means a day other than a Saturday, Sunday or other day on which commercial banks in New York, New York are
authorized or required by law to close. 
 “Capital Lease Obligations” means, with respect to any Person, the obligations
of such Person to pay rent or other amounts under any lease of (or other arrangement conveying the right to use) real or personal property, or a combination thereof, which obligations are required to be classified and accounted for as capital leases
on a balance sheet of such Person under GAAP; and, for the purposes of this Agreement, the amount of such obligations at any time shall be the capitalized amount thereof at such time determined in accordance with GAAP. 

  
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 “Capital Stock” means any and all shares, interests, participations or
other equivalents (however designated) of capital stock of a corporation, any and all equivalent ownership interests in a Person (other than a corporation) and any and all warrants, rights or options to purchase any of the foregoing;
provided, that Capital Stock shall not include any debt securities that are convertible into or exchangeable for any of the foregoing Capital Stock. 

“Change” means a fact, circumstance, condition, development, change, event, occurrence or effect. 

“Change of Control” means (a) the acquisition of ownership, directly or indirectly, beneficially or of record, by any
Person or group (within the meaning of the Securities Exchange Act of 1934 and the rules of the Securities and Exchange Commission thereunder as in effect on the date hereof), of Capital Stock representing more than 35% of the aggregate ordinary
voting power represented by the issued and outstanding Capital Stock of the Borrower; (b) occupation of a majority of the seats (other than vacant seats) on the board of directors of the Borrower by Persons who were neither (i) nominated,
appointed or approved for election by the board of directors of the Borrower nor (ii) appointed by directors so nominated, appointed or approved; (c) the acquisition of direct or indirect Control of the Borrower by any Person or group;
(d) the occurrence of a change in control, or other similar provision, as defined in any agreement or instrument evidencing any Indebtedness (triggering a default or mandatory prepayment, which default or mandatory prepayment has not been
waived in writing); (e) the Borrower shall cease to own, directly or (through another Borrower Affiliates) indirectly, 100% of the capital stock of MIPI; or (f) the Borrower shall enter into any Alternative Acquisition Agreement (as defined in
the Merger Agreement). 
 “Closing Date” means the date on which the conditions precedent in Section 3.1 have been
satisfied. 
 “Code” means the United States Internal Revenue Code of 1986, as amended from time to time. 

“Control” means the possession, direct or indirect, of the power to direct or cause the direction of the management and
policies of a Person, whether through ownership of voting securities, by contract or otherwise. 
 “Default” means any
Event of Default or any condition, occurrence or event which, after notice or lapse of time or both, would constitute an Event of Default. 

“Default Interest” shall have the meaning set forth in Section 2.6(c). 

“Default Interest Rate” means the Loan Interest Rate, plus an additional two percent (2%) per annum. 

“Dollars” and “$” means the lawful currency of the United States of America. 

“Event of Default” shall have the meaning set forth in Section 6.1. 

  
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 “Excluded Taxes” means, with respect to the Lender, (a) Taxes imposed
on or measured by net income (however denominated), franchise taxes, and any branch profits or similar tax imposed by any jurisdiction, in each case, (i) imposed as a result of the Lender being organized under the laws of, or having its
principal office or its applicable lending office located in, the jurisdiction imposing such Tax (or any political subdivision thereof) or (ii) imposed as a result of a present or former connection between the Lender and the jurisdiction
imposing such Tax (other than connections arising from the Lender having executed, delivered, become a party to, performed its obligations under, received payments under, received or perfected a security interest under, engaged in any other
transaction pursuant to or enforced any Loan Document, or sold or assigned an interest in any Loan or Loan Document) (b) U.S. federal withholding Taxes imposed on amounts payable to or for the account of the Lender with respect to an applicable
interest in the Loan pursuant to a law in effect on (i) the date hereof, (ii) the date on which such Lender acquires an interest in the Loan or (iii) the date such Lender changes its lending office, except in each case to the extent
that, pursuant to Section 2.10, amounts with respect to such Taxes were payable either to such Lender’s assignor or successor immediately before such Lender acquired its interest in the Loan or to such Lender immediately before it changed
its lending office, (c) Taxes attributable to the Lender’s failure to comply with Section 2.10(e) and (d) any withholding Taxes imposed under FATCA. 

“FATCA” means Sections 1471 through 1474 of the Code, as of the date of this Agreement (or any amended or successor version
that is substantively comparable and not materially more onerous to comply with), any current or future regulations or official interpretations thereof, any agreements entered into pursuant to Section 1471(b)(1) of the Code and any fiscal or
regulatory legislation, rules or practices adopted pursuant to any intergovernmental agreement, treaty or convention among Governmental Authorities and implementing such Sections of the Code. 

“Foreign Lender” means any Lender that is not a “United States person” as defined in Section 7701(a)(30) of
the Code. 
 “Funding Date” means the date during the Availability Period on which the Loan is made, which shall be a
Business Day, on which the conditions precedent in Section 3.2 have been satisfied. 
 “GAAP” means United States
generally accepted accounting principles applied on a consistent basis. 
 “Governmental Authority” means any nation or
government, any state or other political subdivision thereof and any entity exercising executive, legislative, judicial, regulatory or administrative functions of or pertaining to government. 

“Guarantee Obligation” means as to any Person (the “guaranteeing person”), any obligation of (a) the
guaranteeing person or (b) another Person (including, without limitation, any bank under any letter of credit), if to induce the creation of such obligation of such other Person the guaranteeing person has issued a reimbursement,
counterindemnity or similar obligation, in either case guaranteeing or in effect guaranteeing any Indebtedness, leases, dividends or other obligations (the “primary obligations”) of any other third Person (the “primary
obligor”) in any manner, whether directly or indirectly; provided, however, that the term Guarantee Obligation shall not include endorsements of instruments for deposit 

  
 3 

 
or collection in the ordinary course of business. The amount of any Guarantee Obligation of any guaranteeing person shall be deemed to be the lower of (i) an amount equal to the stated or
determinable amount of the primary obligation in respect of which such Guarantee Obligation is made and (ii) the maximum amount for which such guaranteeing person may be liable pursuant to the terms of the instrument embodying such Guarantee
Obligation, unless such primary obligation and the maximum amount for which such guaranteeing person may be liable are not stated or determinable, in which case the amount of such Guarantee Obligation shall be such guaranteeing person’s maximum
reasonably anticipated liability in respect thereof as determined by the Borrower in good faith. 
 “Hedge Agreements”
means all interest rate or currency swaps, caps or collar agreements, foreign exchange agreements, commodity contracts or similar arrangements entered into by the Borrower or its Subsidiaries providing for protection against fluctuations in interest
rates, currency exchange rates, commodity prices or the exchange of nominal interest obligations, either generally or under specific contingencies. 

“Indebtedness” means, with respect to any Person at any date, without duplication, (a) all indebtedness of such Person
for borrowed money, (b) all obligations of such Person for the deferred purchase price of Property or services (other than trade payables incurred in the ordinary course of such Person’s business), (c) all obligations of such Person
evidenced by notes, bonds, debentures or other similar instruments, (d) all indebtedness created or arising under any conditional sale or other title retention agreement with respect to property or assets acquired by such Person (even though
the rights and remedies of the seller or lender under such agreement in the event of default are limited to repossession or sale of such property or assets), (e) all Capital Lease Obligations of such Person, (f) all obligations of such Person,
contingent or otherwise, as an account party or applicant under acceptance, letter of credit or similar facilities, (g) all obligations of such Person, contingent or otherwise, to purchase, redeem, retire or otherwise acquire for value any
equity interests of such Person, (h) all Guarantee Obligations of such Person in respect of obligations of the kind referred to in clauses (a) through (g) above; (i) all obligations of the kind referred to in clauses (a) through
(h) above secured by (or for which the holder of such obligation has an existing right, contingent or otherwise, to be secured by) any Lien on property (including, without limitation, accounts and contract rights) owned by such Person, whether or
not such Person has assumed or become liable for the payment of such obligation and (j) all obligations of such Person in respect of Hedge Agreements. 

“Indemnified Taxes” means (a) Taxes, other than Excluded Taxes, imposed on or with respect to any payment made by or on
account of any obligation of the Borrower under any Loan Document and (b) to the extent not otherwise described in (a), Other Taxes. 

“Lender” shall have the meaning assigned to such term in the opening paragraph of this Agreement. 

“Lender Indemnitee” means the Lender and each of the directors, officers, employees, and agents of the Lender. 

“Lien” means any mortgage, pledge, hypothecation, assignment, deposit arrangement, encumbrance, lien (statutory or other),
charge or other security interest or any preference, priority or other security agreement or preferential arrangement of any kind or nature whatsoever (including, 

  
 4 

 
without limitation, any conditional sale or other title retention agreement and any capital lease having substantially the same economic effect as any of the foregoing). 

“Loan” shall have the meaning set forth in Section 2.1. 

“Loan Amount” means Ten Million Dollars ($10,000,000). 

“Loan Documents” means, collectively, this Agreement, the Stock Pledge Agreement, and each other agreement, certificate,
document or instrument delivered in connection with this Agreement or the Stock Pledge Agreement (all as may be amended, restated or otherwise modified from time to time). 

“Loan Interest Rate” means nine and a half percent (9.5%) per annum. 

“Material Adverse Effect” means a material adverse effect on (a) the business, assets, liabilities, operations or
condition (financial or otherwise) of the Borrower and its Subsidiaries taken as a whole, (b) the ability of the Borrower to perform its obligations under this Agreement and the other Loan Documents, or (c) the ability of the Lender to
enforce this Agreement or any other Loan Documents. 
 “Maturity Date” means the earlier to occur of
(a) September 30, 2020 and (b) the date on which the Borrower enters into (i) a debt financing (or series of debt financings) or similar arrangements or (ii) any amendment to, or modification or replacement of, any existing
debt financing or similar arrangement, provided by one or more third parties following the Termination Date, in the case of each of clause (i) and (ii), having aggregate net cash proceeds that exceed the amount then required to repay all
Obligations in full in cash. 
 “Merger” shall have the meaning set forth in the Merger Agreement. 

“Merger Agreement” means that certain Amended and Restated Agreement and Plan of Merger, dated as of February 20, 2020,
among Parent, Plato Merger Sub, Inc. and the Borrower (as amended, restated or otherwise modified from time to time). 

“MIPI” means Molecular Insight Pharmaceuticals, Inc. 

“Notice of Borrowing” shall have the meaning set forth in Section 2.2. 

“Obligations” means, with respect to the Borrower, the unpaid principal of and interest on (including, without limitation,
interest accruing after the maturity of the Loan and interest accruing after the filing of any petition in bankruptcy, or the commencement of any insolvency, reorganization or like proceeding, relating to the Borrower, whether or not a claim for
post-filing or post-petition interest is allowed in such proceeding) the Loan and all other obligations and liabilities of the Borrower to the Lender, whether direct or indirect, absolute or contingent, due or to become due, or now existing or
hereafter incurred, which may arise under, out of, or in connection with, any Loan Document. 

  
 5 

 “Other Taxes” means all present or future stamp, court or documentary,
intangible, recording, filing or similar Taxes that arise from any payment made under, from the execution, delivery, performance, enforcement or registration of, from the receipt or perfection of a security interest under, or otherwise with respect
to, any Loan Document. 
 “Parent” means Lantheus Holdings, Inc. 

“Person” means an individual, partnership, corporation, limited liability company, business trust, joint stock company,
trust, unincorporated association, joint venture, Governmental Authority or other entity of whatever nature. 
 “Solvent”
as to any Person at any time, that (a) the fair value of the property of such Person is greater than the total amount of liabilities, including contingent liabilities, of such Person; (b) the present fair salable value of the assets of
such Person is greater than the amount that will be required to pay the probable liability of such Person on the sum of its debts and other liabilities, including contingent liabilities; (c) such Person has not, does not intend to, and does not
believe (nor should it reasonably believe) that it will, incur debts or liabilities beyond such Person’s ability to pay such debts and liabilities as they become due (whether at maturity or otherwise); and (d) such Person does not have
unreasonably small capital with which to conduct the businesses in which it is engaged as such businesses are now conducted and are proposed to be conducted following the Closing Date. 

“Stock Pledge Agreement” means a Pledge and Security Agreement, dated as of the Funding Date, between Borrower and the
Lender, in the form reasonably requested by Lender, pursuant to which all of the outstanding Capital Stock of MIPI (together with all Indebtedness of MIPI owed to the Borrower) is pledged to the Lender as collateral for the Loan, as the same may be
amended, restated or otherwise modified from time to time. 
 “Subsidiary” means as to any Person, a corporation,
partnership, limited liability company or other entity of which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests having such power only by reason of the happening of a
contingency) to elect a majority of the board of directors or other managers of such corporation, partnership or other entity are at the time owned, or the management of which is otherwise Controlled, directly or indirectly through one or more
intermediaries, or both, by such Person. 
 “Taxes” means all present or future taxes, levies, imposts, duties, deductions,
withholdings (including backup withholding), assessments, fees or other charges imposed by any Governmental Authority, including any interest, additions to tax or penalties applicable thereto. 

“Termination Date” means the date (if any) that the Merger Agreement is terminated pursuant to Section 9.1 of the Merger
Agreement. 
 “U.S. Person” means any Person that is a “United States Person” as defined in
Section 7701(a)(30) of the Code. 
 “U.S. Tax Compliance Certificate” shall have the meaning set forth in
Section 2.10(e)(ii)(3). 

  
 6 

Section 1.2    Other Definitional Provisions. 

(a)    Unless otherwise specified therein, all terms defined in this Agreement shall have the defined meanings when used
in the other Loan Documents or any certificate or other document made or delivered pursuant hereto or thereto. 

(b)    The words “hereof”, “herein” and “hereunder” and words of similar import when used in
this Agreement shall refer to this Agreement as a whole and not to any particular provision of this Agreement, and Section, Schedule and Exhibit references are to this Agreement unless otherwise specified. 

(c)    The meanings given to terms defined herein shall be equally applicable to both the singular and plural forms of
such terms. 
 (d)    The terms “Lender” shall include, without limitation, its successors and
assignees. 
 Section 1.3    Accounting Terms and
Principles. Except as set forth below, all accounting terms not specifically defined herein shall be construed in conformity with GAAP and all accounting determinations required to be made pursuant hereto shall, unless expressly otherwise
provided herein, be made in conformity with GAAP. 
 ARTICLE II 

AMOUNT AND TERMS OF THE LOAN 

Section 2.1    Loan Amount. 

(a)    Subject to the terms and conditions set forth herein, the Lender agrees to make a single term loan (the
“Loan”) to the Borrower on the Funding Date in an aggregate principal amount not to exceed the Loan Amount. 

(b)    No amounts paid or prepaid with respect to the Loan may be reborrowed. 

Section 2.2    Borrowing Procedure. The Borrower shall
give the Lender written notice (or telephonic notice promptly confirmed in writing) of such borrowing to be made by the Borrower substantially in the form of Exhibit A (a “Notice of Borrowing”), to be
delivered prior to noon (New York time) three (3) Business Days before the requested date of borrowing (or by such other time and date agreed to by the Lender). 

Section 2.3    Funding. During the Availability Period,
the Lender shall, subject to satisfaction of the conditions set forth in Section 3.2 hereof, make the requested proceeds of the Loan available to the Borrower by wire transfer to the account of the Borrower as specified in the Notice of
Borrowing. For the avoidance of doubt, the commitment of the Lender to make the Loan hereunder shall automatically terminate upon the making of the Loan on the Funding Date. 

Section 2.4    Repayment of Loan. The outstanding
principal balance of the Loan and all accrued and unpaid interest thereon shall be due and payable on the earlier of (i) the Maturity Date, and (ii) the date of the acceleration of the Loan in accordance with Section 6.2. 

  
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Section 2.5    Optional and Mandatory Prepayments.
At any time and from time to time, upon two (2) Business Days’ (or such shorter period agreed by the Lender) written notice from the Borrower to the Lender, the Borrower may voluntarily prepay in whole or in part any unpaid principal
amount of the Loan (provided that any partial voluntary prepayment shall not be in an amount less than $500,000), together with all accrued and unpaid interest thereon, without premium or penalty. Without limiting any other provision hereof, at any
time the Borrower or any Borrower Affiliate receives net cash proceeds from any debt financing or other similar arrangement entered into outside the ordinary course of business, the Borrower shall, within two (2) Business Days thereof, prepay
the Loan in an amount equal to such net cash proceeds. 

Section 2.6    Interest on the Loan. 

(a)    The Loan shall accrue interest at the Loan Interest Rate in accordance with Section 2.7. 

(b)    Interest accrued on the Loan shall be payable in cash, without duplication, (i) on the Maturity Date therefor,
(ii) on the date of any payment or prepayment, in whole or in part, of principal outstanding on the Loan on the principal amount so paid or prepaid, and (iii) on that portion of the Loan that is accelerated pursuant to Section 6.2,
immediately upon such acceleration. 
 (c)    While an Event of Default exists or after acceleration of the Loan in
accordance with Section 6.2, at the option of the Lender, interest on the unpaid principal amount of the Loan (and any accrued and unpaid interest with respect thereto) will accrue at the Default Interest Rate (the “Default
Interest”). All Default Interest will be payable by the Borrower upon demand by the Lender. 

Section 2.7    Computation of Interest. All computations
of interest shall be computed on the basis of the actual number of days (including the first day but excluding the last day) occurring during the period for which such interest is payable over a year comprised of three hundred sixty (360) days.
Each determination by the Lender of an interest amount hereunder shall, except for manifest error, be final, conclusive and binding for all purposes. 

Section 2.8    Evidence of Debt. The Loan made by the
Lender shall be evidenced by one or more accounts or records maintained by the Lender. The accounts or records maintained by the Lender shall be conclusive absent manifest error of the amount of the Loan made by the Lender to the Borrower and the
interest and payments thereon. Any failure so to record or any error in doing so shall not, however, limit or otherwise affect the obligation of the Borrower hereunder to pay any amount owing with respect to the Loan. 

Section 2.9    Payments Generally. 

(a)    All payments by the Borrower to the Lender hereunder shall be made to the Lender in immediately available funds
without setoff or counterclaim not later than 11:00 a.m. New York time on the date due thereof to such account as the Lender shall specify from time to time by notice to the Borrower. Funds received after 11:00 a.m. New York time on any day shall be
deemed to have been received by the Lender on the next succeeding Business Day. If any payment hereunder shall be due on a day that is not a Business Day, the date for payment shall be 

  
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extended to the next succeeding Business Day, and, in the case of the payment accruing interest, interest thereon shall be made payable for the period of such extension. All payments hereunder
shall be made in Dollars. 
 (b)    If on the Maturity Date, insufficient funds are received by and available to the
Lender to pay fully all amounts of principal and interest due hereunder, such funds shall be applied (i) first, towards payment of interest, and (ii) second, towards payment of principal due hereunder. 

Section 2.10    Taxes. 

(a)    Payments Free of Taxes. Any and all payments by the Borrower under each Loan Document shall be made free and
clear of and without deduction for any and all present or future Taxes, except as required by applicable law. If any Taxes shall be required by applicable law to be deducted from or in respect of any sum payable under any Loan Document to the Lender
(as determined in the good faith discretion of the Borrower), then the Borrower shall be entitled to make such deduction or withholding and shall timely pay the full amount deducted or withheld to the relevant Governmental Authority in accordance
with applicable law and, if such Tax is an Indemnified Tax, the sum payable by the Borrower shall be increased as necessary so that after such deduction or withholding has been made (including such deductions and withholdings of Taxes applicable to
additional sums payable under this Section) the Lender receives an amount equal to the sum it would have received had no such deduction or withholding been made. 

(b)    Payment of Other Taxes by the Borrower. The Borrower shall timely pay to the relevant Governmental Authority
in accordance with applicable law, or at the option of the Lender, timely reimburse it for the payment of, any Other Taxes. 

(c)    Indemnification by the Borrower. The Borrower shall indemnify the Lender, within ten (10) days after
demand therefor, for the full amount of any Indemnified Taxes (including Indemnified Taxes imposed or asserted on or attributable to amounts payable under this Section 2.10) payable or paid by the Lender or required to be withheld or deducted
from a payment to the Lender and any reasonable expenses arising therefrom or with respect thereto, whether or not such Indemnified Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority. A certificate as to the
amount of such payment or liability delivered to the Borrower by the Lender shall be conclusive absent manifest error. 

(d)    Evidence of Payments. As soon as practicable after any payment of Taxes by the Borrower to a Governmental
Authority pursuant to this Section, the Borrower shall deliver to the Lender the original or a certified copy of a receipt issued by such Governmental Authority evidencing such payment, a copy of the return reporting such payment or other evidence
of such payment reasonably satisfactory to the Lender. 
 (e)    Status of the Lender. 

(i)    To the extent the Lender is entitled to an exemption from or reduction of withholding Tax with respect to payments
made under any Loan Document, the Lender shall deliver to the Borrower, at the time or times reasonably requested by the Borrower, such properly completed and executed documentation reasonably requested by the Borrower as

  
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will permit such payments to be made without withholding or at a reduced rate of withholding. In addition, the Lender, if reasonably requested by the Borrower, shall deliver such other
documentation prescribed by applicable law or reasonably requested by the Borrower as will enable the Borrower to determine whether or not the Lender is subject to backup withholding or information reporting requirements. Notwithstanding anything to
the contrary in the preceding two sentences, the completion, execution and submission of such documentation (other than such documentation set forth in Section 2.10(e)(ii)) shall not be required if in the Lender’s reasonable judgment such
completion, execution or submission would subject the Lender to any material unreimbursed cost or expense or would materially prejudice the legal or commercial position of the Lender. 

(ii)    Without limiting the generality of the foregoing, 

(A)     if the Lender is a U.S. Person, the Lender shall deliver to the Borrower on the Funding Date (and from time to
time thereafter upon the reasonable request of the Borrower), executed copies of IRS Form W-9 certifying that such Lender is exempt from U.S. federal backup withholding tax; 

(B)     any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to the Borrower (in such number
of copies as shall be requested by the Borrower) on or about the date on which such Foreign Lender becomes a Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Borrower), whichever of the following is
applicable: 
  

	 	(1)	 in the case of a Foreign Lender claiming the benefits of an income tax treaty to which the United States is a
party (x) with respect to payments of interest under any Loan Document, executed copies of IRS Form W-8BEN or IRS Form
W-8BEN-E establishing an exemption from, or reduction of, U.S. federal withholding Tax pursuant to the “interest” article of such tax treaty and (y) with
respect to any other applicable payments under any Loan Document, IRS Form W-8BEN or IRS Form W-8BEN-E establishing an exemption
from, or reduction of, U.S. federal withholding Tax pursuant to the “business profits” or “other income” article of such tax treaty; 

  

	 	(2)	 executed copies of IRS Form W-8ECI; or 

 

	 	(3)	 in the case of a Foreign Lender claiming the benefits of the exemption for portfolio interest under
Section 881(c) of the Code, (x) a certificate substantially in the form of Exhibit B-1 to the effect that such Foreign Lender is not a “bank” within the meaning of Section 881(c)(3)(A)
of the Code, a “10 percent shareholder” of the Borrower within the meaning of Section 871(h)(3)(B) of the Code, or a “controlled foreign corporation” related to the Borrower as described in Section 881(c)(3)(C) of
the Code (a “U.S. Tax Compliance Certificate”) and (y) executed copies of IRS Form W-8BEN or IRS Form
W-8BEN-E; provided that if the Foreign Lender is a partnership and one or more direct or indirect partners of such Foreign

  
 10 

	 	
Lender are claiming the portfolio interest exemption, such Foreign Lender may provide a U.S. Tax Compliance Certificate substantially in the form of Exhibit
B-2 on behalf of each such direct and indirect partner; 

 (C)
    any Foreign Lender shall, to the extent it is legally entitled to do so, deliver to the Borrower (in such number of copies as shall be requested by the Borrower) on or about the date on which such Foreign Lender becomes a
Lender under this Agreement (and from time to time thereafter upon the reasonable request of the Borrower), executed copies of any other form prescribed by applicable law as a basis for claiming exemption from or a reduction in U.S. federal
withholding Tax, duly completed, together with such supplementary documentation as may be prescribed by applicable law to permit the Borrower to determine the withholding or deduction required to be made; and 

(D)     if a payment made to the Lender under any Loan Document would be subject to U.S. federal withholding Tax imposed
by FATCA if such Lender were to fail to comply with the applicable reporting requirements of FATCA (including those contained in Section 1471(b) or 1472(b) of the Code, as applicable), the Lender shall deliver to the Borrower at the time or
times prescribed by law and at such time or times reasonably requested by the Borrower such documentation prescribed by applicable law (including as prescribed by Section 1471(b)(3)(C)(i) of the Code) and such additional documentation
reasonably requested by the Borrower as may be necessary for the Borrower to comply with its obligations under FATCA and to determine that the Lender has complied with the Lender’s obligations under FATCA or to determine the amount, if any, to
deduct and withhold from such payment. Solely for purposes of this clause (D), “FATCA” shall include any amendments made to FATCA after the date of this Agreement. The Lender agrees that if any form or certification it previously delivered
expires or becomes obsolete or inaccurate in any respect, it shall update such form or certification or promptly notify the Borrower in writing of its legal inability to do so. 

(f)      Treatment of Certain Refunds. If any party determines, in its sole discretion exercised in good
faith, that it has received a refund of any Taxes as to which it has been indemnified pursuant to this Section (including by the payment of additional amounts pursuant to this Section), it shall pay to the indemnifying party an amount equal to such
refund (but only to the extent of indemnity payments made under this Section with respect to the Taxes giving rise to such refund), net of all out-of-pocket expenses
(including Taxes) of such indemnified party and without interest (other than any interest paid by the relevant Governmental Authority with respect to such refund). Such indemnifying party, upon the request of such indemnified party, shall repay to
such indemnified party the amount paid over pursuant to this Section 2.10(f) (plus any penalties, interest or other charges imposed by the relevant Governmental Authority) in the event that such indemnified party is required to repay such
refund to such Governmental Authority. Notwithstanding anything to the contrary in this Section 2.10(f), in no event will the indemnified party be required to pay any amount to an indemnifying party pursuant to this Section 2.10(f) the
payment of which would place the indemnified party in a less favorable net after-Tax position than the indemnified party would have been in if the Tax subject to indemnification and giving rise to such refund
had not been deducted, withheld or otherwise imposed and the indemnification payments or additional amounts with respect to such Tax had never been paid. This Section 2.10(f) shall not be construed to require any indemnified party to make
available its Tax returns (or any other information relating to its Taxes that it deems confidential) to the indemnifying party or any other Person. 

  
 11 

 (g)    Survival. Each party’s obligations under this
Section 2.10 shall survive any assignment of rights by, or the replacement of, a Lender and the repayment, satisfaction or discharge of all obligations under any Loan Document. 

Section 2.11    
Illegality. Notwithstanding any other provision of this Agreement, if the Lender determines that it is unlawful for the Lender to make the Loan or to continue to fund or maintain the Loan, then, on written notice thereof and demand therefor by
the Lender to the Borrower, (a) the obligation of the Lender to make or to continue the Loan shall be suspended, and (b) if the Loan is then outstanding, the Borrower shall prepay the unpaid principal amount of the Loan, together with
accrued interest thereon, within five (5) Business Days. 

ARTICLE III 

CONDITIONS PRECEDENT TO THE LOAN 

Section 3.1    Conditions
to Closing. The obligation of the Lender to consummate the transactions contemplated by this Agreement and make available the Loan during the Availability Period shall be subject to the satisfaction (or waiver in accordance with
Section 7.2) of each of the conditions precedent set forth below: 
 (a)    the execution and delivery of this
Agreement by the parties hereto; 
 (b)    no Default or Event of Default shall exist on the Closing Date; and 

(c)    all representations and warranties of the Borrower set forth herein shall be true and correct in all material
respects on and as of the Closing Date. 

Section 3.2    Conditions
Precedent to Making the Loan. The obligation of the Lender to make the Loan on the Funding Date shall be subject to the satisfaction (or waiver in accordance with Section 7.2) of each of the conditions precedent set forth below: 

(a)    The Closing Date shall have occurred; 

(b)    execution and delivery of the Stock Pledge Agreement by the parties thereto and delivery of certificates of shares
of Capital Stock of Molecular Insight Pharmaceuticals, Inc., together with an undated stock power for each such certificate executed in blank by a duly authorized officer of the Borrower; 

(c)    the delivery by the Borrower of a Notice of Borrowing pursuant to Section 2.2; 

(d)    all representations and warranties of the Borrower set forth in the Loan Documents shall be true and correct in all
material respects on and as of the Funding Date; 
 (e)    no law shall have been adopted or promulgated after the date
of the Merger Agreement, and no temporary restraining order, preliminary or permanent injunction or other order shall have been issued and remain in effect, by a Governmental Authority of competent jurisdiction having the effect of making the Loan
or the Merger illegal or otherwise prohibiting consummation of the Merger or funding of the Loan; 
 (f)    no Default
or Event of Default shall exist on the Funding Date; 

  
 12 

 (g)    the Board of Directors of Borrower shall not have made any Change
in Recommendation (as defined in the Merger Agreement) and neither the Borrower nor any of its subsidiaries or their respective representatives shall have breached any of their respective obligations under Section 7.5 of the Merger Agreement;

 (h)    the Termination Date shall not have occurred under the Merger Agreement; and 

(i)    there shall not have occurred (i) a material breach by Borrower under the Merger Agreement or (ii) a
Material Adverse Effect (as defined in the Merger Agreement), in respect of which Parent has validly terminated the Merger Agreement. 
 
ARTICLE IV 
 REPRESENTATIONS AND WARRANTIES 

To induce the Lender to enter into this Agreement and to make the Loan, the Borrower hereby represents and warrants to the Lender for itself
that: 
 Section 4.1    Corporate Existence. The
Borrower (a) is duly incorporated, validly organized and in good standing under the laws of the jurisdiction of its incorporation and (b) has the power and authority to own and operate its property and assets, to lease the property and
assets it operates as lessee and to conduct the business in which it is currently engaged, and (c) is duly qualified to do business and is in good standing as a foreign entity in each jurisdiction where the nature of its business requires such
qualification except, to the extent that the failure to comply therewith could not, in the aggregate, reasonably be expected to have a Material Adverse Effect. 

Section 4.2    Power; Authorization; Enforceable
Obligations. 
 (a)    The Borrower has the power and authority to make, deliver and perform the Loan Documents to
which it is a party and to borrow hereunder. The Borrower has taken all necessary action to authorize the execution, delivery and performance of the Loan Documents to which it is a party and, to authorize the borrowings on the terms and conditions
of this Agreement. 
 (b)    No consent or authorization of, filing with, notice to or other act by or in respect of,
any Governmental Authority or any other Person is required to be obtained by the Borrower or any Borrower Affiliate in connection with (i) the borrowings hereunder or (ii) the execution, delivery, or performance of this Agreement or any of
the other Loan Documents, except, in each case, for routine consents, authorizations, filings and notices required to be made in the ordinary course of business. 

(c)    This Agreement has been, and, upon execution, each Loan Document shall have been, duly executed and delivered on
behalf of the Borrower. 

  
 13 

 (d)    This Agreement constitutes, and each other Loan Document upon
execution will constitute, a legal, valid and binding obligation of the Borrower, enforceable against the Borrower in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium
or similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles (whether enforcement is sought by proceedings in equity or at law). 

Section 4.3    No Legal Bar. The execution, delivery and
performance of this Agreement and the other Loan Documents by the Borrower and the borrowings hereunder will not violate any applicable law or any material agreement of the Borrower or any Borrower Affiliate and will not result in, or require, the
creation or imposition of any Lien on any of its properties or revenues pursuant to any requirement of applicable law or any such agreement. 

Section 4.4    No Material Litigation; No MIPI
Borrower Affiliate Indebtedness. No litigation, investigation or proceeding of or before any arbitrator or Governmental Authority is pending or, to the knowledge of the Borrower, threatened in writing by or against the Borrower or any Borrower
Affiliate, or against any of its or their respective properties or revenues, that (a) purport to affect or pertain to this Agreement or any other Loan Document, or any of the transactions contemplated hereby or thereby or (b) if adversely
determined, could reasonably be expected to have a Material Adverse Effect. There is no outstanding Indebtedness of MIPI or any of its Subsidiaries owing to any Borrower Affiliate (other than to Borrower, MIPI or any of MIPI’s other
Subsidiaries). 
 Section 4.5    No Default. No
Default or Event of Default has occurred and is continuing. 

Section 4.6    Solvency. Borrower and its Subsidiaries
(on a consolidated basis), after giving effect to the Loan and the incurrence of all Indebtedness and obligations being incurred in connection herewith and therewith, will be and will continue to be Solvent. 

ARTICLE V 

COVENANTS 
 From the date
hereof and until payment in full of all Obligations and the termination hereof, the Borrower shall: 

Section 5.1    Delivery of Financial Information. Deliver
to the Lender (a) within 90 days after the end of each fiscal year of Borrower, its audited financial statements; and (b) within 45 days after the end of each of the first three fiscal quarters of each fiscal year of the Borrower, its
unaudited financial statements; provided, that (i) the Borrower shall be deemed to have complied with the terms of clauses (a) and (b), as applicable, if the Borrower delivers such financial statements to the Lender within the same time
frame required under the Securities Act and the rules and regulations of the SEC its annual report on Form 10-K for the applicable fiscal year or its quarterly report in Form
10-Q for the applicable fiscal quarter, respectively, that it has filed with the SEC, and (ii) any documents required to be delivered pursuant to clauses (a) and (b) shall be deemed to have been
delivered on the date on which the Borrower provides notice to the Lender that such information has been posted on the Borrower’s website. 

Section 5.2    Notice of Default. Promptly give notice
to the Lender of the occurrence of any Default or Event of Default within five (5) Business Days after the Borrower has knowledge thereof. 

  
 14 

Section 5.3    Compliance with Merger Agreement
Covenants. 
 (a)    Comply with the covenants of the Company (as defined therein) set forth in Sections 6.1
and 7.10 of the Merger Agreement, with the same effect as if such covenants were fully incorporated herein, mutatis mutandis (as if each reference therein to “the Company” were a reference to the Borrower and each reference therein
to “this Agreement” were a reference to this Agreement); 
 (b)    Not, without the prior consent of the
Lender, permit MIPI to (i) declare, set aside, make or pay any dividend or other distribution (whether in cash, stock or property) in respect of any of its Securities (as defined in the Merger Agreement), other than dividends or distributions
by wholly-owned Subsidiaries of MIPI to MIPI or a wholly-owned Subsidiary of MIPI, (ii) split, subdivide, consolidate, combine or reclassify any of its Securities or issue or allot, or propose or authorize the issuance or allotment of, any
other Securities or Equity Rights (as defined in the Merger Agreement) in respect of, in lieu of, or in substitution for, any of its Securities, (iii) repurchase, redeem or otherwise acquire any Securities or Equity Rights of MIPI or any
Subsidiary of MIPI, (iv) issue, allot, sell, grant, pledge or otherwise encumber any Securities or Equity Rights, (v) merge or consolidate with any Person, or acquire the Securities in, or any material amount of assets of, any other
Person, or (vi) incur of suffer to exist (or permit any Subsidiary of MIPI to incur or suffer to exist) any Indebtedness owing to any Borrower Affiliate (other than to Borrower, MIPI or any of MIPI’s other Subsidiaries); and 

(c)    Cause MIPI to comply with the covenants of the Company (as defined therein) set forth in Sections 6.1 and 7.10
of the Merger Agreement (other than clauses (b), (c) and (d) of Section 6.1 (which covenants are covered in clause (b) above)), with the same effect as if such covenants were fully incorporated herein, mutatis mutandis (as if
each reference therein to “the Company” were a reference to MIPI, each reference therein to “the Company Subsidiaries” (or any similar phrase) were a reference to Subsidiaries of MIPI, and each reference therein to “this
Agreement” were a reference to this Agreement). 
 For avoidance of doubt, such covenants incorporated hereby shall continue hereunder notwithstanding
any termination of the Merger Agreement. 

Section 5.4    Use of Proceeds. Use the proceeds of the
Loan to fund working capital and for other general corporate purposes; provided that the proceeds of the Loan shall not be used in connection with any related party transaction, the purchase or repurchase of any Capital Stock, acquisition of assets
or other merger activity unrelated to the Merger Agreement, or in any manner that would reasonably be expected to prevent the Merger from constituting a Tax-free reorganization described in Section 368(a)
and related provisions of the Code. 
 Section 5.5    Debt
Financing. Promptly following the Termination Date, if any, Borrower shall use all commercially reasonable efforts to enter into a debt financing with net cash proceeds in excess of the amount then required to repay all Obligations in full in
cash. 

  
 15 

 ARTICLE VI 

EVENTS OF DEFAULT 
 
Section 6.1    Events of Default. The occurrence of any of the following events shall constitute an “Event of Default”: 

(a)    The Borrower shall fail to pay (i) the principal of the Loan on the date when due (including the Maturity Date)
in accordance with the terms hereof; or (ii) any interest on the Loan, or any other amount payable hereunder or under any other Loan Document, and in the case of clause (ii), such failure shall continue unremedied for a period of three (3)
Business Days after any such interest or other amount becomes due in accordance with the terms hereof or thereof; or 

(b)    Any representation or warranty made or deemed made by the Borrower or any Borrower Affiliate herein or in any other
Loan Document or that is contained in any certificate, document or financial or other statement furnished by it at any time under or in connection with this Agreement or any such other Loan Document shall prove to have been inaccurate in any
material respect on or as of the date made or deemed made or furnished; or 
 (c)    The Borrower shall default in the
observance or performance of any agreement contained in this Agreement or any other Loan Document to be performed by it (other than as provided in Section 6.1(a)), and such default shall continue unremedied for a period of thirty (30) days
after the earlier of (i) the date on which an officer of the Borrower becomes aware of such failure and (ii) the date on which written notice thereof shall have been given to the Borrower by the Lender; or 

(d)    (i) The Borrower or any Borrower Affiliate shall fail to make any payment on any Indebtedness (other than the
Obligations) of the Borrower or any Borrower Affiliate or on any Guarantee Obligation in respect of Indebtedness of any other Person, and, in each case, such failure relates to Indebtedness having a principal amount of Five Million Dollars
($5,000,000) or more, when the same becomes due and payable (whether by scheduled maturity, required prepayment, acceleration, demand or otherwise), (ii) any other event shall occur or condition shall exist under any agreement or instrument relating
to any such Indebtedness, if the effect of such event or condition is to accelerate the maturity of such Indebtedness, (iii) any other event shall occur or condition shall exist under any agreement or instrument relating to any such
Indebtedness, if the effect of such event or condition is to permit the acceleration of the maturity of such Indebtedness or (iv) any such Indebtedness shall become or be declared to be due and payable, or be required to be prepaid or
repurchased (other than by a regularly scheduled required prepayment), prior to the stated maturity thereof; or 

(e)    (i) The Borrower or any Borrower Affiliate shall commence any case, proceeding or other action (A) under any
existing or future law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency, reorganization or relief of debtors, seeking to have an order for relief entered with respect to it, or seeking to adjudicate it a bankrupt or
insolvent, or seeking reorganization, arrangement, adjustment, winding up, liquidation, dissolution, composition or other relief with respect to it or its debts, or (B) seeking appointment of a receiver, trustee, custodian, conservator or other
similar official for it or for all or any substantial part of its assets, or the Borrower or any Borrower Affiliate shall make a general assignment for the benefit of its creditors; or (ii) there shall be commenced against the Borrower or any
Borrower Affiliate any case, proceeding or other action of a nature referred to in clause (i) above that (A) results in the entry of an order for relief or any such adjudication or appointment or (B) remains undismissed,

  
 16 

 
undischarged or unbonded for a period of sixty (60) days; or (iii) there shall be commenced against the Borrower or any Borrower Affiliate any case, proceeding or other action seeking
issuance of a warrant of attachment, execution, distraint or similar process against all or any substantial part of its assets that results in the entry of an order for any such relief that shall not have been vacated, discharged, or stayed or
bonded pending appeal within sixty (60) days from the entry thereof; or (iv) the Borrower or any Borrower Affiliate shall take any action in furtherance of, or indicating its consent to, approval of, or acquiescence in, any of the acts set
forth in clause (i), (ii), or (iii) above; or (v) the Borrower or any Borrower Affiliate shall generally not, or shall be unable to, or shall admit in writing its inability to, pay its debts as they become due; or 

(f)    Except pursuant to a valid, binding and enforceable termination or release permitted under the Loan Documents and
executed by the Lender, or as otherwise expressly permitted under any Loan Document, any provision of any Loan Document shall, at any time after the delivery of such Loan Document, fail to be, or be asserted in writing by the Borrower or any
Borrower Affiliate not to be valid and binding on, or enforceable against, the Borrower, or the Borrower or any Borrower Affiliate shall state in writing that any of the foregoing events shall have occurred; or the Stock Pledge Agreement ceases to
create a valid Lien with the priority required thereby on the Collateral covered thereby; or 
 (g)    A Change of
Control (other than consummation of the Merger) shall have occurred. 

Section 6.2    Remedies. Upon the occurrence of any
Event of Default specified in Section 6.1(e)(i) or (ii), the obligation of the Lender to make available the Loan shall immediately terminate, the unpaid principal amount of the Loan (with accrued interest thereon) and all other amounts owing
under this Agreement and the other Loan Documents shall immediately become due and payable, and the Lender shall be entitled to take all available remedies under applicable law. Upon the occurrence and during the continuance of any other Event of
Default, the Lender (a) may, by notice to the Borrower, terminate its obligation to make available the Loan, whereupon such obligation shall immediately terminate, (b) may, by notice to the Borrower, declare the unpaid principal amount of
the Loan (with accrued interest thereon) and all other amounts owing under this Agreement and the other Loan Documents to be due and payable forthwith, whereupon the same shall immediately become due and payable, and (c) shall be entitled to
take all available remedies under applicable law. 
 ARTICLE VII 

MISCELLANEOUS 
 
Section 7.1    Notices. 
 (a)    Addresses for Notices.
All notices, demands, requests, consents and other communications provided for in this Agreement shall be given in writing (including email communication), and sent via overnight courier, mailed, emailed, or delivered: 

  
 17 

 If to the Borrower: 

Progenics Pharmaceuticals, Inc. 

One World Trade Center, 47th Floor 

New York, NY 10007 
 Attention:
David Mims 
 Email: dmims@progenics.com 

Attention: Chief Financial Officer 

with a copy (which shall not constitute notice) to: 

O’Melveny & Myers LLP 

Times Square Tower 
 7 Times
Square 
 New York, NY 10036 

Attention: Sung Pak, Esq. 
 Email:
spak@omm.com 
 Attention: Tobias Knapp, Esq. 

Email: tknapp@omm.com 
 If to the
Lender: 
 Lantheus Medical Imaging, Inc. 

331 Treble Cove Road 
 North
Billerica, MA 02160 
 Attention: General Counsel 

Email: michael.duffy@lantheus.com 

with a copy (which shall not constitute notice) to: 

White & Case LLP 
 1221
Avenue of the Americas 
 New York, NY 10020-1095 

Attention: Morton A. Pierce, Esq. 

Bryan J. Luchs, Esq. 
 Email:
morton.pierce@whitecase.com 
 Any party hereto may change its address, telephone number or email address for notices and other communications hereunder by
notice to the other parties hereto. All such notices and other communications shall, when transmitted by overnight delivery, be effective when delivered for overnight (next-day) delivery, or if mailed, upon
the third Business Day after the date deposited into the mail or if delivered, upon delivery. All such notices, demands, requests, consents and other communications shall, when mailed, or emailed, be effective (x) when delivered to such email
address (and confirmed by delivery receipt), (y) if delivered by hand, including any overnight courier service, upon personal delivery, or (z) if delivered by mail, when deposited in the mails, respectively. 

  
 18 

Section 7.2    Waiver; Amendments. No amendment or waiver
of any provision of this Agreement or any other Loan Document nor consent to any departure by the Borrower therefrom shall in any event be effective unless the same shall be in writing and (a) in the case of any such waiver or consent, signed
by the Lender and (b) in the case of any other amendment, by the Lender and the Borrower, and then any such waiver or consent shall be effective only in the specific instance and for the specific purpose for which given. 

Section 7.3    Expenses; Indemnification. 

(a)    The Borrower shall be obligated to pay all
out-of-pocket costs and expenses (including, without limitation, but not limited to the reasonable fees, charges and out-of-pocket disbursements of a single outside counsel for the Lender) incurred by the Lender in connection with the enforcement or protection of its rights in connection with this Agreement and the other
Loan Documents, including its rights under this Section 7.3, including all such out-of-pocket expenses incurred during any workout, restructuring or negotiations in
respect of the Loan. 
 (b)    The Borrower shall be obligated to indemnify each Lender Indemnitee against, and hold
each Lender Indemnitee harmless from, any and all losses, claims, damages, liabilities and related expenses (including the fees, charges and out-of-pocket disbursements
of a single counsel for all Lender Indemnitees taken as a whole) incurred by any Lender Indemnitee or asserted against any Lender Indemnitee by any third party or by the Borrower arising out of, in connection with, or as a result of (i) the
execution or delivery of this Agreement, any other Loan Document or any agreement or instrument contemplated hereby or thereby, the performance by the parties hereto of their respective obligations hereunder or thereunder or the consummation of the
transactions contemplated hereby or thereby, or (ii) any actual or prospective claim, litigation, investigation or proceeding relating to any of the foregoing, whether based on contract, tort or any other theory, whether brought by a third
party or by the Borrower, and regardless of whether any Lender Indemnitee is a party thereto, provided that such indemnity shall not, as to any Lender Indemnitee, be available to the extent that such losses, claims, damages, liabilities or related
expenses (x) are determined by a court of competent jurisdiction by final judgment to have resulted from the gross negligence or willful misconduct of such Lender Indemnitee or (y) breach in bad faith of such Lender Indemnitee’s
obligations hereunder or under any other Loan Document, if the Borrower has obtained a final judgment in their favor on such claim as determined by a court of competent jurisdiction. 

(c)    To the extent permitted by applicable law, each party shall not assert, and hereby waives, any claim against any
Lender Indemnitee or the other party, on any theory of liability, for special, indirect, consequential or punitive damages (as opposed to actual or direct damages) arising out of, in connection with or as a result of, this Agreement, any other Loan
Document or any agreement or instrument contemplated hereby or thereby, the transactions contemplated therein, the Loan or the use of proceeds thereof. 

(d)    All amounts due under this Section 7.3 shall be payable promptly after written demand therefor. 

Section 7.4    Successors and Assigns. The provisions of
this Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns 

  
 19 

 
permitted hereby, except that the Borrower may not assign or otherwise transfer any of its rights or obligations hereunder without the prior written consent of the Lender, and the Lender may not
assign or otherwise transfer any of its rights or obligations hereunder without the prior written consent of the Borrower; provided, however, that Lender may (a) pledge its interest in the Loan and this Agreement as collateral pursuant to its
existing credit facility or any replacement thereof and (b) assign this Agreement without consent of the Borrower, but with reasonably prompt notice to the Borrower, (i) in connection with a merger, acquisition, recapitalization,
reorganization, change of control or sale of all or substantially all of its assets, business or product line to which this Agreement relates, (ii) to any Controlled or Controlling affiliate of the Lender or (C) at any time following the
occurrence of an Event of Default. Any other attempted assignment or transfer by any party hereto shall be null and void. Nothing in this Agreement, expressed or implied, shall be construed to confer upon any Person (other than the parties hereto,
their respective successors and assigns permitted hereby and, to the extent expressly contemplated hereby, each Lender Indemnitee) any legal or equitable right, remedy or claim under or by reason of this Agreement. 

Section 7.5    Governing Law; Consent to Jurisdiction;
Waiver of Jury Trial. 
 (a)    Each Loan Document and the rights and obligations of the parties hereto and thereto
shall be governed by, and construed and interpreted in accordance with, the law of the State of New York. 
 (b)    ALL
JUDICIAL PROCEEDINGS ARISING OUT OF OR RELATING TO THE LOAN DOCUMENTS MAY BE BROUGHT IN ANY COURT OF THE BOROUGH OF MANHATTAN IN THE CITY OF NEW YORK IN THE STATE OF NEW YORK OR IN THE UNITED STATES DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW
YORK, AND BY EXECUTION AND DELIVERY OF THIS AGREEMENT, EACH OF THE PARTIES HERETO ACCEPTS FOR ITSELF AND IN CONNECTION WITH ITS PROPERTIES, GENERALLY AND UNCONDITIONALLY, THE NONEXCLUSIVE JURISDICTION OF THE AFORESAID COURTS AND WAIVES ANY DEFENSE
OF FORUM NON CONVENIENS AND IRREVOCABLY AGREES TO BE BOUND BY ANY JUDGMENT RENDERED THEREBY IN CONNECTION WITH THE LOAN DOCUMENTS. 

(c)    TO THE MAXIMUM EXTENT PERMITTED BY APPLICABLE LAW, EACH OF THE BORROWER AND THE LENDER HEREBY WAIVES ANY RIGHT TO A
TRIAL BY JURY IN ANY ACTION OR PROCEEDING ARISING OUT OF OR RELATING TO THE LOAN DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED HEREUNDER OR THEREUNDER. 

Section 7.6    Counterparts; Integration. This Agreement
may be executed in any number of counterparts and by electronic means (including “pdf”) and by different parties in separate counterparts, each of which when so executed shall be deemed to be an original and all of which taken together
shall constitute one and the same agreement. 

Section 7.7    Survival. All covenants, agreements,
representations and warranties made by the Borrower herein and in the certificates or other instruments delivered in connection with or pursuant to this Agreement shall be considered to have been relied upon by the Lender and shall survive the
execution and delivery of this Agreement and the making of the Loan. The provisions of Section 7.3 shall survive and remain in full force and effect regardless of the consummation of the transactions contemplated hereby, the repayment of the
Loan or the termination of this Agreement or any provision hereof. 

  
 20 

Section 7.8    Severability. Any provision of this
Agreement or any other Loan Document held to be illegal, invalid or unenforceable in any jurisdiction, shall, as to such jurisdiction, be ineffective to the extent of such illegality, invalidity or unenforceability without affecting the legality,
validity or enforceability of the remaining provisions hereof or thereof; and the illegality, invalidity or unenforceability of a particular provision in a particular jurisdiction shall not invalidate or render unenforceable such provision in any
other jurisdiction. 
 [Signature Pages Follow] 

  
 21 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the day and year first above written. 
  

					
	 PROGENICS PHARMACEUTICALS, INC.,

as Borrower

 
					
		
	By:	 	 /s/ Patrick Fabbio

					
			
		 	Name:	 	 Patrick Fabbio

		 	Title:	 	 CFO

 
					
	
	 LANTHEUS MEDICAL IMAGING, INC.,

as Lender

 
					
		
	By:	 	 /s/ Robert J. Marshall
Jr.

 
					
			
		 	Name:	 	 Robert J. Marshall Jr.

		 	Title:	 	 CFO and Treasurer

 [Signature Page to Bridge Loan Agreement] 

 EXHIBIT A 

FORM OF NOTICE OF BORROWING 
 [DATE] 

[●] 
 [Address] 

Dear Sirs: 
 Reference is made to that certain
Bridge Loan Agreement, dated as of March 15, 2020 (as amended, restated, or otherwise modified from time to time, the “Loan Agreement”), by and among PROGENICS PHARMACEUTICALS, INC. (the “Borrower”) and
LANTHEUS MEDICAL IMAGING, INC. (the “Lender”). 
 The Borrower hereby requests the following Loan under the Loan Agreement,
and in that connection the Borrower specifies the following information with respect to such Loan: 
  

	 	(a)	 Principal Amount of Loan: $[●] 

 

	 	(b)	 Date of Loan: [●] 

 

	 	(c)	 The Borrower hereby certifies as follows: 

 

	 	(i)	 At the time of and immediately after giving effect to the making of the requested Loan, no Default or Event of
Default exists. 

  

	 	(ii)	 At the time of and immediately after giving effect to the making of the requested Loan, all representations and
warranties of the Borrower set forth in the Loan Documents are true and correct in all material respects on and as of such date. 

IN WITNESS WHEREOF, the undersigned has caused this Notice of Borrowing to be executed on the date first written above. 

 

					
	PROGENICS PHARMACEUTICALS, INC.
as Borrower

 
					
		
	By:	 	  

 
					
			
	      	 	Name:	 	  

		 	Title:	 	  

 EXHIBIT B-1 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Lenders That Are Not Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Bridge Loan Agreement dated as of March 15, 2020 (as amended, supplemented or otherwise modified from
time to time, the “Loan Agreement”), between Progenics Pharmaceuticals, Inc. and Lantheus Medical Imaging, Inc. 
 Pursuant
to the provisions of Section 2.10 of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record and beneficial owner of the Loan (as well as any Loan Documents evidencing such Loan) in respect of which it is
providing this certificate, (ii) it is not a “bank” within the meaning of Section 881(c)(3)(A) of the Code, (iii) it is not a “10-percent shareholder” of the Borrower within
the meaning of Section 871(h)(3)(B) of the Code and (iv) it is not a “controlled foreign corporation” related to the Borrower as described in Section 881(c)(3)(C) of the Code. 

The undersigned has furnished the Borrower with a certificate of its non-U.S. Person status on
IRS Form W-8BEN or IRS Form W-8BEN-E. By executing this certificate, the undersigned agrees that (1) if the
information provided in this certificate changes, the undersigned shall promptly so inform the Borrower, and (2) the undersigned shall have at all times furnished the Borrower with a properly completed and currently effective certificate in
either the calendar year in which each payment is to be made to the undersigned, or in either of the two calendar years preceding such payments. 

Unless otherwise defined herein, terms defined in the Loan Agreement and used herein shall have the meanings given to them in the Loan
Agreement. 
 [NAME OF LENDER] 
  

			
	By:	 	  

			
	Name:	 	
	Title:	 	

 Date:
                    , 20[    ] 

 EXHIBIT B-2 

FORM OF U.S. TAX COMPLIANCE CERTIFICATE 

(For Foreign Lenders That Are Partnerships For U.S. Federal Income Tax Purposes) 

Reference is hereby made to the Bridge Loan Agreement dated as of March 15, 2020 (as amended, supplemented or otherwise modified from
time to time, the “Loan Agreement”), between Progenics Pharmaceuticals, Inc. and Lantheus Medical Imaging, Inc. 
 Pursuant
to the provisions of Section 2.10 of the Loan Agreement, the undersigned hereby certifies that (i) it is the sole record owner of the Loan (as well as any Loan Documents evidencing such Loan) in respect of which it is providing this
certificate, (ii) its direct or indirect partners/members are the sole beneficial owners of such Loan (as well as any Loan Documents evidencing such Loan), (iii) with respect to the extension of credit pursuant to the Loan Agreement or any
other Loan Document, neither the undersigned nor any of its direct or indirect partners/members is a “bank” extending credit pursuant to a loan agreement entered into in the ordinary course of its trade or business within the meaning of
Section 881(c)(3)(A) of the Code, (iv) none of its direct or indirect partners/members is a “10-percent shareholder” of the Borrower within the meaning of Section 871(h)(3)(B) of the
Code and (v) none of its direct or indirect partners/members is a “controlled foreign corporation” related to the Borrower as described in Section 881(c)(3)(C) of the Code. 

The undersigned has furnished the Borrower with IRS Form W-8IMY accompanied by one of the
following forms from each of its partners/members that is claiming the portfolio interest exemption: (i) an IRS Form W-8BEN or IRS
Form W-8BEN-E or (ii) an IRS Form W-8IMY accompanied by an IRS
Form W-8BEN or IRS Form W-8BEN-E from each of such partner’s/member’s beneficial owners that is claiming the
portfolio interest exemption. By executing this certificate, the undersigned agrees that (1) if the information provided in this certificate changes, the undersigned shall promptly so inform the Borrower, and (2) the undersigned shall have
at all times furnished the Borrower with a properly completed and currently effective certificate in either the calendar year in which each payment is to be made to the undersigned, or in either of the two calendar years preceding such payments.

 Unless otherwise defined herein, terms defined in the Loan Agreement and used herein shall have the meanings given to them in the Loan
Agreement. 
 [NAME OF LENDER] 
  

			
	By:	 	  

			
	Name:	 	
	Title:	 	

 Date:
                    , 20[    ]Exhibit 4.1

        

        

        EXECUTION VERSION

      

       

      

      SUPPLEMENTAL INDENTURE NO. 4

       

      THIS SUPPLEMENTAL INDENTURE NO. 4, dated as of March 16, 2020 (this “Supplemental
            Indenture”), between CIGNA CORPORATION, a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), and U.S. BANK
            NATIONAL ASSOCIATION, a national banking association duly organized and existing under the laws of the United States of America, as trustee (the “Trustee”).

       

      RECITALS OF THE COMPANY:

       

      WHEREAS, the Company and the Trustee are parties to an Indenture, dated as of September 17, 2018 (the “Base Indenture” and, as supplemented by this Supplemental Indenture, the “Indenture”),

        relating to the issuance from time to time by the Company of its Securities on terms to be specified at the time of issuance;

       

      WHEREAS, Section 9.01(7) of the Base Indenture provides that the Company may enter into a supplemental indenture to establish the terms and provisions of Securities of any series issued
        pursuant to the Indenture;

       

      WHEREAS, the Company desires to issue three separate series of Securities, and has duly authorized the creation and issuance of such Securities and the execution and delivery of this Supplemental
        Indenture to modify the Base Indenture and provide certain additional provisions as hereinafter described;

       

      WHEREAS, the parties hereto deem it advisable to enter into this Supplemental Indenture for the purpose of establishing the terms of such Securities, providing for the rights, obligations and
        duties of the Trustee with respect to such Securities; and

       

      WHEREAS, all conditions and requirements of the Base Indenture necessary to make this Supplemental Indenture a valid, binding and legal instrument in accordance with its terms have been performed
        and fulfilled by the parties hereto.

       

      NOW, THEREFORE, for and in consideration of the premises and other good and valuable consideration, receipt of which is hereby acknowledged by the parties hereto, the parties hereto agree as
        follows:

       

      ARTICLE I

        

        THE SENIOR NOTES

       

      Section 1.01      Title of Securities.  There shall be a series of Securities designated the “2.400% Senior Notes due 2030” of the Company (the “2030 Notes”), a series of Securities
        designated the “3.200% Senior Notes due 2040” of the Company (the “2040 Notes”) and a series of Securities designated the “3.400% Senior Notes due 2050” of the Company (the “2050 Notes” and, together with the 2030 Notes and the 2040
        Notes, the “Senior Notes”).

       

      

      
        
          

      

      
      Section 1.02      Limitation of Aggregate Principal Amount.

       

      (a)          The aggregate principal amount of the 2030 Notes shall initially be limited to $1,500,000,000.

       

      (b)          The aggregate principal amount of the 2040 Notes shall initially be limited to $750,000,000.

       

      (c)          The aggregate principal amount of the 2050 Notes shall initially be limited to $1,250,000,000.

       

      (d)         For each series of Senior Notes, the aggregate principal amount specified in this Section shall be subject to the amount of such series that is authenticated and delivered upon
        registration of transfer of, or in exchange for, or in lieu of, such series pursuant to Section 3.04, 3.05, 3.06, 9.06 or 11.07 of the Base Indenture and the amount of such series which, pursuant to Section

          3.03 of the Base Indenture, is deemed never to have been authenticated and delivered thereunder.

       

      (e)          The Company may from time to time, without notice to or the consent of the Holders of any series of Senior Notes, create and issue further Senior Notes of any such series ranking
        equally with, and having the same terms and conditions as, the Senior Notes of such series (and being treated as a single class with the Senior Notes of such series) in all respects (or in all respects other than the payment of interest accruing
        prior to the issue date of such further Senior Notes) (“Additional Senior Notes”); provided, however, that if such Additional Senior Notes are not fungible with the initial Senior Notes of such series for U.S. federal income
        tax purposes, such Additional Senior Notes will have a separate CUSIP number.

       

      Section 1.03      Principal Payment Date.

       

      (a)          The principal amount of the 2030 Notes outstanding (together with any accrued and unpaid interest) shall be payable in a single installment on March 15, 2030, which date shall be the
        Stated Maturity of the 2030 Notes.

       

      (b)          The principal amount of the 2040 Notes outstanding (together with any accrued and unpaid interest) shall be payable in a single installment on March 15, 2040, which date shall be the
        Stated Maturity of the 2040 Notes.

       

      (c)          The principal amount of the 2050 Notes outstanding (together with any accrued and unpaid interest) shall be payable in a single installment on March 15, 2050, which date shall be the
        Stated Maturity of the 2050 Notes.

       

      Section 1.04      Interest and Interest Rates.

       

      (a)         The rate of interest on each 2030 Note shall be 2.400% per annum, accruing from the date of original issuance or from the most recent date to which interest has been paid or duly
        provided for, and interest on each 2030 Note shall be payable semi-annually in arrears on March 15 and September 15 of each year, commencing on September 15, 2020, and on the Maturity of such series.

       

      
        -2-

        
          

      

      (b)         The rate of interest on each 2040 Note shall be 3.200% per annum, accruing from the date of original issuance or from the most recent date to which interest has been paid or duly
        provided for, and interest on each 2040 Note shall be payable semi-annually in arrears on March 15 and September 15 of each year, commencing on September 15, 2020, and on the Maturity of such series.

       

      (c)         The rate of interest on each 2050 Note shall be 3.400% per annum, accruing from the date of original issuance or from the most recent date to which interest has been paid or duly
        provided for, and interest on each 2050 Note shall be payable semi-annually in arrears on March 15 and September 15 of each year, commencing on September 15, 2020, and on the Maturity of such series.

       

      Section 1.05      Place of Payment.  The place where the Senior Notes may be presented or surrendered for payment, where the Senior Notes may be surrendered for registration of transfer or
        exchange and where notices and demand to or upon the Company in respect of the Senior Notes and the Indenture may be served shall be the Corporate Trust Office of the Trustee or the Paying Agent’s office maintained for that purpose in the Borough
        of Manhattan, City of New York.

       

      Section 1.06      Optional Redemption.  (a)  At any time prior to the Par Call Date (as defined below) in respect of the 2030 Notes, the 2040 Notes or the 2050 Notes, the Company may
        redeem the Senior Notes of such series, in whole or in part, at a redemption price equal to the greater of (i) 100% of the principal amount of the 2030 Notes, the 2040 Notes or the 2050 Notes to be redeemed and (ii) the sum of the present values of
        the remaining scheduled payments of principal and interest (excluding interest accrued to the Redemption Date) on the 2030 Notes, the 2040 Notes or the 2050 Notes to be redeemed from the Redemption Date to the Par Call Date of such series of Senior
        Notes, discounted to the Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the applicable Treasury Rate plus 25 basis points in the case of the 2030 Notes, plus 25 basis points in the case of the
        2040 Notes and plus 30 basis points in the case of the 2050 Notes, plus accrued and unpaid interest, if any, on the principal amount of the Senior Notes being redeemed to, but excluding, the Redemption Date. At any time on or after the Par Call
        Date in respect of a series of Senior Notes, the Company may redeem the Senior Notes of such series, in whole or in part, at a redemption price equal to 100% of the principal amount of such Senior Notes being redeemed, plus accrued and unpaid
        interest, if any, on the principal amount of the Senior Notes being redeemed to, but excluding, the Redemption Date (such redemption, a “Par Call”). Unless the Company defaults in payment of the Redemption
        Price, interest will cease to accrue on the Senior Notes or portions of the Senior Notes called for redemption on and after the Redemption Date.

       

      (b)         Notice of any redemption of the Senior Notes shall be mailed or otherwise delivered in accordance with the applicable procedures of the Depository in accordance with Section 11.04
        of the Base Indenture at least 10 days but not more than 60 days before the Redemption Date to each Holder of the 2030 Notes, the 2040 Notes or the 2050 Notes to be redeemed.  If less than all of the Senior Notes then Outstanding of any series are
        to be redeemed, the Trustee will select the particular Senior Notes of the series or portions thereof in accordance with Section 11.03 of the Base Indenture.

       

      
        -3-

        
          

      

      (c)          Notice of any redemption of the Senior Notes in connection with a transaction or an event may, at the Company’s discretion, be given prior to the completion or the occurrence thereof.
        Any redemption or notice may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to, completion or occurrence of a related transaction or event. At the Company’s discretion, the Redemption Date
        may be delayed until such time as any or all such conditions shall be satisfied, or such redemption may not occur and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the Redemption Date, or
        by the Redemption Date as so delayed. The Company shall, at its own cost and expense, provide, or arrange for written notice of any such delay, non-occurrence or rescission to be given to the holders of the Securities  and the Trustee prior to the
        Redemption Date; provided that, at the Company’s written request provided to the Trustee prior to the Redemption Date, notice, prepared by the Company, of
        any such delay, non-occurrence or rescission shall be given by the Trustee in the name and at the expense of the Company.

       

      (d)          For the purposes of this Section 1.06, the terms below are defined as follows:

       

      “Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having a maturity comparable to the remaining term of the 2030 Notes,
        the 2040 Notes or the 2050 Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of
        the 2030 Notes, the 2040 Notes or the 2050 Notes to be redeemed (assuming, for this purpose, that such 2030 Notes, 2040 Notes or 2050 Notes mature on the Par Call Date applicable thereto).

       

      “Comparable Treasury Price” means, with respect to any Redemption Date for any 2030 Notes, any 2040 Notes or any 2050 Notes, the average of all Reference Treasury Dealer Quotations obtained
        by the Company.

       

      “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company from time to time.

       

      “Par Call Date” means December 15, 2029 (three months prior to the Stated Maturity of the 2030 Notes) in respect of the 2030 Notes, September 15, 2039 (six months prior to the Stated
        Maturity of the 2040 Notes) in respect of the 2040 Notes and September 15, 2049 (six months prior to the Stated Maturity of the 2050 Notes) in respect of the 2050 Notes.

       

      “Primary Treasury Dealer” means a primary U.S. government securities dealer in the United States.

       

      “Reference Treasury Dealer” means each of BofA Securities, Inc., Goldman Sachs & Co. LLC and Morgan Stanley & Co. LLC and their respective successors. If any Reference Treasury
        Dealer ceases to be a Primary Treasury Dealer, the Company will substitute another Primary Treasury Dealer for that dealer.

       

      

      
        -4-

        
          

      

      “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the bid and asked prices
        for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by that Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such
        Redemption Date.

       

      “Treasury Rate” means, with respect to any Redemption Date, (1) the yield, under the heading which represents the average for the immediately preceding week, appearing in the most recently
        published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes yields on actively traded United States Treasury securities
        adjusted to constant maturity under the caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the Stated Maturity for the 2030 Notes, the 2040
        Notes or the 2050 Notes to be redeemed, yields for the two published maturities most closely corresponding to the Comparable Treasury Issue will be determined and the Treasury Rate shall be interpolated or extrapolated from such yields on a
        straight line basis, rounding to the nearest month) or (2) if such release referred to in clause (1) (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per annum
        equal to the semi-annual equivalent yield-to-maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such
        Redemption Date. The Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.

       

      Section 1.07      [Reserved].

       

      Section 1.08      Change of Control Offer.  (a)  If a Change of Control Triggering Event (as defined below) occurs with respect to any series of Senior Notes, unless the Company has
        exercised its right to redeem such Senior Notes in full, the Company will make an offer to each Holder (the “Change of Control Offer”) of such Senior Notes to repurchase any and all of such Holder’s Senior Notes of such series, at a
        repurchase price in cash equal to 101% of the aggregate principal amount of the Senior Notes of such series repurchased, plus any accrued and unpaid interest thereon to, but excluding, the date of repurchase (the “Change of Control Payment”). 

        Within 30 days following any Change of Control Triggering Event, the Company will send a notice to Holders of Senior Notes of such series describing the transaction or transactions that constitute the Change of Control Triggering Event and offering
        to repurchase the Senior Notes on the date specified in the notice, which date will be no less than 15 days and no more than 60 days from the date such notice is sent (the “Change of Control Payment Date”), pursuant to the procedures
        required by the Senior Notes and described in such notice.

       

      (b)         The Company will comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and
        regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Senior Notes as a result of a Change of Control Triggering Event.  To the extent that the provisions of any securities laws or
        regulations conflict with the Change of Control repurchase provisions of the Senior Notes the Company will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of
        Control repurchase provisions of the Senior Notes by virtue of such conflicts.

       

      

      
        -5-

        
          

      

      (c)          The Company will not be required to offer to repurchase the Senior Notes upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and
        otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases on the applicable date all Senior Notes properly tendered and not withdrawn under its offer; provided that for all purposes of
        the Senior Notes and the Indenture, a failure by such third party to comply with the requirements of such offer and to complete such offer shall be treated as a failure by the Company to comply with its obligations to offer to repurchase the Senior
        Notes unless the Company promptly makes an offer to repurchase the Senior Notes at 101% of the principal amount thereof plus accrued and unpaid interest, if any, thereon, to, but excluding, the date of repurchase, which shall be no later than 30
        days after the third party’s scheduled Change of Control Payment Date.

       

      (d)          On the Change of Control Payment Date, the Company will, to the extent lawful:

       

      (i)        accept or cause a third party to accept for payment all Senior Notes properly tendered pursuant to the Change of Control Offer;

       

      (ii)       deposit or cause a third party to deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Senior Notes properly tendered; and

       

      

      (i)        deliver or cause to be delivered to the Trustee the Senior Notes properly accepted, together with an Officers’ Certificate stating the principal amount of the Senior
        Notes being purchased.

       

      (e)          For the purposes of this Section 1.08, the terms below are defined as follows:

       

      “Below Investment Grade Rating Event” with respect to any series of Senior Notes means such Senior Notes are rated below all Investment Grade Ratings by at least two of the three Rating
        Agencies on any date from the earlier of (1) the occurrence of a Change of Control and (2) public notice of the Company’s intention to effect a Change of Control, in each case until the end of the 60-day period following public notice of the
        occurrence of the Change of Control; provided, however, that if (a) during such 60-day period, one or more Rating Agencies has publicly announced that it is considering the possible downgrade of such series of Senior Notes, and (b)
        a downgrade by each of the Rating Agencies that has made such an announcement would result in a Below Investment Grade Rating Event, then such 60-day period shall be extended for such time as the rating of such series of Senior Notes by any such
        Rating Agency remains under publicly announced consideration for possible downgrade to a rating below an Investment Grade Rating and a downgrade by such Rating Agency to a rating below an Investment Grade Rating could cause a Below Investment Grade
        Rating Event. Notwithstanding the foregoing, a rating event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a rating event
        for purposes of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Trustee in writing at the
        Company’s or the Trustee’s request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the applicable Change
        of Control has occurred at the time of the rating event).

       

      

      
        -6-

        
          

      

      “Change of Control” means the occurrence of any of the following: (1) direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in
        one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than to the
        Company or one of its subsidiaries; or (2) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
        other than the Company or one of its subsidiaries becomes the beneficial owner, directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s voting stock; provided, however, that a transaction
        will not be deemed to involve a Change of Control if (A) the Company becomes a wholly owned subsidiary of a holding company and (B)(x) the holders of the voting stock of such holding company immediately following that transaction are substantially
        the same as the holders of the Company’s voting stock immediately prior to that transaction or (y) immediately following that transaction no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) is the beneficial owner, directly
        or indirectly, of more than 50% of the voting stock of such holding company. For purposes of this definition, “voting stock” of a person means capital stock of any class or kind the holders of which are ordinarily, in the absence of
        contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to vote has been suspended by the happening of such a contingency.

       

      “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade Rating Event.

       

       “Fitch” means Fitch Ratings Inc. and any successor to its rating agency business.

       

      “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under a successor rating category of Moody’s), a rating by S&P equal to or higher than
        BBB- (or the equivalent under any successor rating category of S&P), a rating by Fitch equal to or higher than BBB- (or the equivalent under any successor rating category of Fitch), and the equivalent investment grade credit rating from any
        replacement rating agency or rating agencies selected by the Company under the circumstances permitting the Company to select a replacement rating agency and in the manner for selecting a replacement rating agency, in each case as set forth in the
        definition of “Rating Agencies.”

       

      “Moody’s” means Moody’s Investors Service, Inc. and any successor to its rating agency business.

       

      

      
        -7-

        
          

      

      “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any or all of Moody’s, S&P or Fitch ceases to rate any series of the Senior Notes or fails to make a rating of any
        series of the Senior Notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that the Company selects (pursuant to a
        resolution of the Company’s Board of Directors) as a replacement rating agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be, with respect to such series of the Senior Notes, as applicable.

       

      “S&P” means Standard & Poor’s Ratings Services, a Standard & Poor’s Financial Services LLC business and any successor to its rating agency business.

       

      Section 1.09      Sinking Fund Obligations.  The Company has no obligation to redeem or purchase any Senior Notes pursuant to any sinking fund or analogous requirement or upon the happening
        of a specified event or at the option of a Holder thereof.

       

      Section 1.10      Denomination.  The Senior Notes shall be issuable only in registered form without coupons and in denominations of $2,000 and multiples of $1,000 in excess thereof.

       

      Section 1.11      Currency.  Principal and interest on the Senior Notes shall be payable in such coin or currency of the United States of America that at the time of payment is legal tender
        for payment of public and private debts.

       

      Section 1.12      Senior Notes to be Issued in Global Form.  Each of the Senior Notes will be permanently represented by one or more securities in global form (collectively, the “Global
          Notes”). The Company hereby designates The Depository Trust Company as the initial Depository for the Global Notes.

       

      Section 1.13      Form of Senior Notes.  The 2030 Notes shall be substantially in the form attached as Annex A hereto, the 2040 Notes shall be substantially in the form attached as
        Annex B hereto and the 2050 Notes shall be substantially in the form attached as Annex C hereto.

       

      Section 1.14      Security Registrar and Paying Agent for the Senior Notes.  The Trustee shall serve initially as the Security Registrar and the Paying Agent for the Senior Notes.

       

      Section 1.15      Money for Securities Payments to Be Held in Trust. Section 10.03 of the Base Indenture is hereby replaced in its entirety with the below provisions.

       

      If the Company shall at any time act as its own Paying Agent with respect to any series of Securities, it will, on or before each due date of the principal of (and premium, if any) or interest on
        any of the Securities of that series, segregate and hold in trust for the benefit of the Persons entitled thereto a sum sufficient to pay the principal (and premium, if any) or interest so becoming due until such sums shall be paid to such Persons
        or otherwise disposed of as herein provided and will promptly notify the Trustee of its action or failure so to act.

       

      Whenever the Company shall have one or more Paying Agents for any series of Securities, it will, on or before each due date of the principal of (and premium, if any) or interest on any Securities
        of that series, deposit with a Paying Agent a sum sufficient to pay such amount, such sum to be held as provided by the Trust Indenture Act to the extent that the Trust Indenture Act applies to this Indenture or any Securities, and (unless such
        Paying Agent is the Trustee) the Company will promptly notify the Trustee of its action or failure so to act.

       

      

      
        -8-

        
          

      

      The Company will cause each Paying Agent for any series of Securities other than the Trustee or the Company to execute and deliver to the Trustee an instrument in which such Paying Agent shall
        agree with the Trustee, subject to the provisions of this Section, that such Paying Agent will (i) comply with the provisions of the Trust Indenture Act applicable to it as a Paying Agent and (ii) during the continuance of any default by the
        Company (or any other obligor upon the Securities of that series) in the making of any payment in respect of the Securities of that series, and upon the written request of the Trustee, forthwith pay to the Trustee all sums held in trust by such
        Paying Agent for payment in respect of the Securities of that series.

       

      The Company may at any time, for the purpose of obtaining the satisfaction and discharge of this Indenture or for any other purpose, pay, or by Company Order direct any Paying Agent to pay, to the
        Trustee all sums held in trust by the Company or such Paying Agent, such sums to be held by the Trustee upon the same trusts as those upon which such sums were held by the Company or such Paying Agent; and, upon such payment by any Paying Agent to
        the Trustee, such Paying Agent shall be released from all further liability with respect to such money.

       

      Any money deposited with the Trustee or any Paying Agent, or then held by the Company, in trust for the payment of the principal of (and premium, if any) or interest on any Security of any series
        and remaining unclaimed for two years after such principal (and premium, if any) or interest has become due and payable shall be paid to the Company on Company Request, or (if then held by the Company) shall be discharged from such trust; and the
        Holder of such Security shall thereafter, as an unsecured general creditor, look only to the Company for payment thereof, and all liability of the Trustee or such Paying Agent with respect to such trust money, and all liability of the Company as
        trustee thereof, shall thereupon cease.

       

      Section 1.16      Defeasance.  The provisions of Section 10.06 of the Base Indenture shall apply to the Senior Notes.

       

      ARTICLE II

        

        MISCELLANEOUS

       

      Section 2.01      Integral Part; Effect of Supplement on Indenture.  This Supplemental Indenture constitutes an integral part of the Indenture.  Except for the amendments and
        supplements made by this Supplemental Indenture (which only apply to the Senior Notes and any other Securities issued thereunder), the Base Indenture shall remain in full force and effect as executed.

       

      Section 2.02      General Definitions.  For purposes of this Supplemental Indenture:

       

      (a)          Capitalized terms used herein without definition shall have the meanings specified in the Base Indenture;

       

      (b)          All references to Articles and Sections, unless otherwise specified, refer to the corresponding Articles and Sections of the Base Indenture; and

        

      

      
        -9-

        
          

      

      (c)          The terms “herein,” “hereof,” “hereunder” and other words of similar import refer to this Supplemental Indenture.

       

      Section 2.03      Adoption, Ratification and Confirmation.  The Base Indenture, as supplemented by this Supplemental Indenture, is in all respects hereby adopted, ratified and confirmed.

       

      Section 2.04    Trustee Not Responsible for Recitals. The recitals in this Supplemental Indenture are made by the Company, and the Trustee assumes no responsibility for the correctness of
        such recitals.  The Trustee makes no representations as to the validity or sufficiency of this Supplemental Indenture.

       

      Section 2.05      Counterparts.  This Supplemental Indenture may be executed in multiple counterparts, each of which shall be regarded for all purposes as an original and all of which shall
        constitute but one and the same instrument.

       

      Section 2.06      Governing Law.  This Supplemental Indenture and the Senior Notes shall be governed by and construed in accordance with the laws of the State of New York applicable to
        agreements made or instruments entered into and, in each case, performed in said state.

      

      

      [signature page follows]

      

      

      
        -10-

        
          

      

      IN WITNESS WHEREOF, the Company and the Trustee have executed this Supplemental Indenture as of the date first above written.

       

      	 	
              CIGNA CORPORATION

            
	 	 	 
	 	
              By

            	
              /s/ Timothy D. Buckley

            
	 	 	
              Name: Timothy D. Buckley

            
	 	 	
              Title: Vice President and Treasurer

            

      

      

      	 	
              U.S. BANK NATIONAL ASSOCIATION

            
	 	 	 
	 	
              By

            	
              /s/ Christopher J. Grell

            
	 	 	
              Name: Christopher J. Grell

            
	 	 	
              Title: Vice President

            

      

        [Supplemental Indenture Signature Page]

        

      

      
        -11-

        
          

      

      
      ANNEX A

        

          FORM OF 2030 GLOBAL NOTE

       

      UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION, NEW YORK, NEW YORK, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
        PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
        IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INSOMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST
        HEREIN.

       

      THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE AND IS REGISTERED IN THE NAME OF CEDE & CO.  THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
        TRANSFERS OF THIS GLOBAL SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN NOMINEES OF CEDE & CO. OR A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE.

       

      CIGNA CORPORATION

        2.400% Senior Notes Due 2030

      

      

      

      CUSIP: 125523CL2

      ISIN: US125523CL22

      

      

      
        	
                No. [       ]

              	
                Principal Amount  $[        ]

              

      

      

      CIGNA CORPORATION, a Delaware corporation (herein called the “Company”), which term includes any successor Person under the Indenture hereinafter referred to, for value received, hereby
        promises to pay to CEDE & CO., or its registered assigns, the principal sum of [___] Million Dollars ($[________]) upon presentation and surrender of this Security on March 15, 2030 and to pay interest thereon accruing from March 16, 2020, or
        from the most recent date to which interest has been paid or duly provided for, semi-annually in arrears on March 15 and September 15 of each year, commencing September 15, 2020, and on the Maturity of this Security (each an “Interest Payment
          Date”), at the rate of 2.400% per annum, until the principal hereof is paid or made available for payment. The amount of interest payable on this Security on any Interest Payment Date shall be computed on the basis of a 360-day year
        consisting of twelve 30-day months. The amount of interest payable for any period shorter than a full monthly period shall be computed on the basis of the actual number of calendar days elapsed in such a period. The interest so payable, and
        punctually paid or duly provided for, on any Interest Payment Date will be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date, which shall be the
        close of business on the date that is 15 calendar days prior to the date on which interest is scheduled to be paid, regardless of whether such date is a Business Day (provided that if this Security is held
        by a securities depositary in book-entry form, the Regular Record Date for this security will be the close of business on the Business Day immediately preceding the date on which interest is scheduled to be paid; provided,
        further, that interest payable on the relevant Maturity will be payable to the Persons to whom the principal of this Security is payable).  If an Interest Payment Date is not a Business Day, then such
        Interest Payment Date shall be the next succeeding Business Day, and no further interest will accrue as a result of such delay. Any such interest not punctually paid or duly provided for on any Interest Payment Date shall forthwith cease to be
        payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such
        Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 calendar days prior to such Special Record Date, or be paid at any time in any other lawful manner not
        inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.

       

      

      
        A-1

        
          

      

      Payment of the principal of (and premium, if any) and interest on this Security will be made at the Corporate Trust Office of the Trustee or the Paying Agent’s office maintained for that purpose in
        the Borough of Manhattan, City of New York, in such coin or currency of the United States of America that at the time of payment is legal tender for payment of public and private debts; provided, however, that at the option of the
        Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.

       

      Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this
        place.

       

      Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the
        Indenture or be valid or obligatory for any purpose.

       

      

      
        A-2

        
          

      

      IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

       

      

      
        
          	
                   

                	
                  
                    
                      CIGNA CORPORATION

                    

                  

                
	
                   

                	
                   

                
	
                   

                	
                  
                    
                      By:

                    

                  

                	 
	
                   

                	
                  
                    
                      Name:

                    

                  

                	 
	 	
                  Title:

                	 

           

          

        

      

      	
              Attest:

            	 
	 	 
	
              Name:

            	
              

              

            
	
              Title:

            	 

       

      

      
        A-3

        
          

      

      TRUSTEE’S CERTIFICATE OF AUTHENTICATION

       

      This is one of the Securities of the series designated under, and referred to in, the within-mentioned Indenture.

       

      

      	

            	
              U.S. BANK NATIONAL ASSOCIATION,

            
	 	
              as Trustee

            
	 	 	 
	 	
              By:

            	 
	 	 	
              Authorized Signatory

            

      

      

      
        A-4

        
          

      

      [REVERSE SIDE OF SECURITY]

        

        CIGNA CORPORATION

        2.400% Senior Notes due 2030

       

      This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more series under an Indenture, dated as of
        September 17, 2018 (the “Base Indenture”), as supplemented by Supplemental Indenture No. 4, dated as of March 16, 2020 (the “Supplemental Indenture” and, together with the Base Indenture, the “Indenture”), between the Company,
        as issuer, and U.S. Bank National Association, as trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto reference is hereby made for a
        statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. 
        This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,500,000,000, subject to future issuances of additional Securities pursuant to Section 3.01 of the Base Indenture.

       

      At any time prior to the Par Call Date (as defined below), the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by
        mail (or as otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed and (ii) the sum
        of the present values of the remaining scheduled payments of principal and interest (excluding interest accrued to the Redemption Date) on the Securities to be redeemed from the Redemption Date to the Par Call Date discounted to the Redemption Date
        on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate, plus 25 basis points, plus accrued and unpaid interest, if any, on the principal amount of the Securities being redeemed to, but excluding,
        the Redemption Date (the “Make Whole Redemption Price”).

       

      At any time on or after the Par Call Date, the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by mail (or as
        otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to 100% of the principal amount of the Securities being redeemed plus accrued and unpaid interest, if any, on the
        principal amount of the Securities being redeemed to, but excluding, the Redemption Date (together with the Make Whole Redemption Price, the “Redemption Price”).

       

      “Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having a maturity comparable to the remaining term of the Securities of
        this series to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Securities of
        this series to be redeemed (assuming, for this purpose, that the Securities of this series mature on the Par Call Date).

       

      

      
        A-5

        
          

      

      “Comparable Treasury Price” means, with respect to any Redemption Date for any Securities of this series, the average of all Reference Treasury Dealer Quotations obtained by the Company.

       

      “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company from time to time.

       

      “Par Call Date” means December 15, 2029 (three months prior to the Stated Maturity of the Securities of this series).

       

      “Primary Treasury Dealer” means a primary U.S. government securities dealer in the United States.

       

      “Reference Treasury Dealer” means each of BofA Securities, Inc., Goldman Sachs & Co. LLC and Morgan Stanley & Co. LLC and their respective successors. If any Reference Treasury
        Dealer ceases to be a Primary Treasury Dealer, the Company will substitute another Primary Treasury Dealer for that dealer.

       

      “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the bid and asked prices
        for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by that Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such
        Redemption Date.

       

      “Treasury Rate” means, with respect to any Redemption Date, (1) the yield, under the heading which represents the average for the immediately preceding week, appearing in the most recently
        published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes yields on actively traded United States Treasury securities
        adjusted to constant maturity under the caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the Stated Maturity for the Securities of this
        series, yields for the two published maturities most closely corresponding to the Comparable Treasury Issue will be determined and the Treasury Rate shall be interpolated or extrapolated from such yields on a straight line basis, rounding to the
        nearest month) or (2) if such release referred to in clause (1) (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per annum equal to the semi-annual equivalent
        yield-to-maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date.

       

      The Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.

       

      Unless the Company defaults in payment of the Redemption Price, interest will cease to accrue on the Securities of this series called for redemption on and after the Redemption Date.  In the event
        of redemption of this Security in part only, a new Security or Securities of this series for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.

       

      
        A-6

        
          

      

      
        Notice of any redemption of the Securities of this series in connection with a transaction or an event may, at the Company’s discretion, be given prior to the completion or the occurrence thereof. Any redemption or
          notice may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to, completion or occurrence of a related transaction or event. At the Company’s discretion, the Redemption Date may be delayed
          until such time as any or all such conditions shall be satisfied, or such redemption may not occur and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the Redemption Date, or by the
          Redemption Date as so delayed.

      

       

      If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities of this series in full, the Company will make an offer to each Holder (the “Change

          of Control Offer”) of such Securities to repurchase any and all of such Holder’s Securities at a repurchase price in cash equal to 101% of the aggregate principal amount of the Securities of this series repurchased, plus any accrued and
        unpaid interest thereon to, but excluding, date of repurchase (the “Change of Control Payment”).  Within 30 days following any Change of Control Triggering Event, the Company will send a notice to Holders of Securities of this series
        describing the transaction or transactions that constitute the Change of Control Triggering Event and offering to repurchase the Securities of this series on the date specified in the notice, which date will be no less than 15 days and no more than
        60 days from the date such notice is sent (the “Change of Control Payment Date”), pursuant to the procedures required hereby and described in such notice.

       

      The Company will comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations
        thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities of this series as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or
        regulations conflict with the Change of Control repurchase provisions of the Securities of this series, the Company will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the
        Change of Control repurchase provisions of the Securities of this series by virtue of such conflicts.

       

      The Company will not be required to offer to repurchase the Securities of this series upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner,
        at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases on the applicable date all Securities of this series properly tendered and not withdrawn under its offer; provided that for all purposes of the Securities of this series and the Indenture, a failure by such third party to comply with the requirements of such offer and to complete such offer shall be treated as a failure by
        the Company to comply with its obligations to offer to purchase the Securities of this series unless the Company promptly makes an offer to repurchase the Securities of this series at 101% of the principal amount thereof plus accrued and unpaid
        interest, if any, thereon, to, but excluding, to the date of repurchase, which shall be no later than 30 days after the third party’s scheduled Change of Control Payment Date.

       

      

      
        A-7

        
          

      

      On the Change of Control Payment Date, the Company will, to the extent lawful:

       

      
        
          	

                	•	
                  accept or cause a third party to accept for payment all Securities of this series properly tendered pursuant to the Change of Control Offer;

                

        

      

       

      
        
          	

                	•	
                  deposit or cause a third party to deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities of this series properly tendered; and

                

        

      

       

      
        
          	

                	•	
                  deliver or cause to be delivered to the Trustee the Securities of this series properly accepted, together with an Officers’ Certificate stating the principal amount of the Securities of this series being repurchased.

                

        

      

       

      “Below Investment Grade Rating Event” means the Securities of this series are rated below all Investment Grade Ratings by at least two of the three Rating Agencies on any date from the
        earlier of (1) the occurrence of a Change of Control and (2) public notice of the Company’s intention to effect a Change of Control, in each case until the end of the 60-day period following public notice of the occurrence of the Change of Control;
        provided, however, that if (i) during such 60-day period one or more Rating Agencies has publicly announced that it is considering the possible downgrade of the Securities of this series, and
        (ii) a downgrade by each of the Rating Agencies that has made such an announcement would result in a Below Investment Grade Rating Event, then such 60-day period shall be extended for such time as the rating of the Securities of this series by any
        such Rating Agency remains under publicly announced consideration for possible downgrade to a rating below an Investment Grade Rating and a downgrade by such Rating Agency to a rating below an Investment Grade Rating could cause a Below Investment
        Grade Rating Event. Notwithstanding the foregoing, a rating event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a rating
        event for purposes of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Trustee in writing at
        the Company’s or the Trustee’s request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the applicable
        Change of Control has occurred at the time of the rating event).

       

      “Change of Control” means the occurrence of any of the following: (1) direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in
        one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than to the
        Company or one of its subsidiaries; or (2) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
        other than the Company or one of its subsidiaries becomes the beneficial owner, directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s voting stock;  provided, however,
        that a transaction will not be deemed to involve a Change of Control if (A) the Company becomes a wholly owned subsidiary of a holding company and (B)(x) the holders of the voting stock of such holding company immediately following that transaction
        are substantially the same as the holders of the Company’s voting stock immediately prior to that transaction or (y) immediately following that transaction no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) is the beneficial
        owner, directly or indirectly, of more than 50% of the voting stock of such holding company. For purposes of this definition, “voting stock” of a person means capital stock of any class or kind the holders of which are ordinarily, in the
        absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to vote has been suspended by the happening of such a contingency.

       

      

      
        A-8

        
          

      

      “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade Rating Event.

       

       “Fitch” means Fitch Ratings Inc. and any successor to its rating agency business.

       

      “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under a successor rating category of Moody’s), a rating by S&P equal to or higher than
        BBB- (or the equivalent under any successor rating category of S&P), a rating by Fitch equal to or higher than BBB- (or the equivalent under any successor rating category of Fitch), and the equivalent investment grade credit rating from any
        replacement rating agency or rating agencies selected by the Company under the circumstances permitting the Company to select a replacement rating agency and in the manner for selecting a replacement rating agency, in each case as set forth in the
        definition of “Rating Agencies.”

       

      “Moody’s” means Moody’s Investors Service, Inc. and any successor to its rating agency business.

       

      “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any or all of Moody’s, S&P or Fitch ceases to rate the Securities of this series or fails to make a rating of the
        Securities of this series publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that the Company selects (pursuant to a
        resolution of the Company’s Board of Directors) as a replacement rating agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be, with respect to the Securities of this series, as applicable.

       

      “S&P” means Standard & Poor’s Ratings Services, a Standard & Poor’s Financial Services LLC business and any successor to its rating agency business.

       

      If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with
        the effect provided in the Indenture.

       

      The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the
        Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of each
        series to be affected.  The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of
        such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.  Any such consent or waiver by the Holder of this Security shall be conclusive and
        binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this
        Security.

       

      

      
        A-9

        
          

      

      No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Company, or the right of the Holder of this Security, which is
        absolute and unconditional, to pay, or, in the case of the Holder of this Security, to receive payment of, the principal of (and premium, if any) and interest on this Security at the times, place and rate, and in the coin or currency, herein
        prescribed.

       

      As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the Security Register, upon surrender of this Security for
        registration of transfer at the Corporate Trust Office of the Trustee or the Paying Agent’s office where the principal of (and premium, if any) and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of
        transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or such Holder’s attorney duly authorized in writing; and thereupon one or more new Securities of this series and of like tenor, of
        authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.

       

      The Securities of this series are issuable only in fully registered form, without coupons, in denominations of $2,000 and multiples of $1,000 in excess thereof.  As provided in the Indenture and
        subject to certain limitations therein set forth, Securities of this series are exchangeable for other Securities of this series, of a like tenor and aggregate principal amount but of a different authorized denomination, as requested by the Holder
        surrendering the same.

       

      No service charge shall be made for any such registration of transfer or exchange, but the Company or the Trustee may require payment of a sum sufficient to cover any tax or other governmental
        charge that may be imposed in connection with any registration of transfer or exchange of Securities, other than exchanges pursuant to Sections 3.04, 9.06 or 11.07 of the Base Indenture not involving any transfer.

       

      Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is
        registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

       

      The Indenture provides that the Company, at the Company’s option, (a) will be discharged from any and all obligations in respect of the Securities (except for certain obligations to register
        the transfer or exchange of Securities, replace stolen, lost or mutilated Securities, maintain paying agencies and hold moneys for payment in trust) or (b) need not comply with certain restrictive covenants of the Indenture, in each case if
        the Company deposits, in trust with the Trustee, money, or U.S. Government Obligations which through the payment of interest thereon and principal thereof in accordance with their terms will provide money, in an amount sufficient to pay all the
        principal (including any mandatory sinking fund payments) of (and premium, if any) or interest on the Securities on the dates such payments are due in accordance with the terms of such Securities, and certain other conditions are satisfied.

       

      No recourse shall be had for the payment of the principal of or premium, if any, or interest, if any, on this Security, or for any claim based hereon, or otherwise in respect hereof, or based on or
        in respect of the Indenture or any indenture supplemental thereto, against any incorporator, or against any past, present or future stockholder, officer, director, employee, or agent, as such, of the Company or of any successor Person thereof,
        whether by virtue of any law, statute or constitutional provision, or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly waived and released as a condition of, and as
        consideration for, the execution of this Indenture and the issue of the Securities.

       

      If and to the extent that any provision of this Security limits, qualifies or conflicts with a provision of the Indenture, such provision of the Indenture shall control.

       

      All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.

       

      

      
        A-10

        
          

      

      ASSIGNMENT FORM

       

      

      	
              I or we assign and transfer this Security to:

              

            	 

      	 	 
	
              Insert social security or other identifying number of assignee

            	 
	

            
	 	 
	
              Print or type name, address and zip code of assignee

            	 
	

            
	

            
	 	 
	
              and irrevocably appoint _______________________, as agent, to transfer this Security on the books of the Company.

            
	 	 
	
              The agent may substitute another to act for him.

            	 
	 	 

      	
              Date:

              

            	 	 

      	 	 
	

            	
              
                Signed

              

            	 
	
              

              

            	
              (Sign exactly as name appears on the other side of this Security)

            

       
        Signature Guarantee*:

         

        

      

      
        
          	*	
                  Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such
                    other “signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

                

        

      

      

      

      
        A-11

        
          

      

      
      ANNEX B

          

          FORM OF 2040 GLOBAL NOTE

       

      UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION, NEW YORK, NEW YORK, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
        PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
        IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INSOMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST
        HEREIN.

       

      THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE AND IS REGISTERED IN THE NAME OF CEDE & CO.  THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
        TRANSFERS OF THIS GLOBAL SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN NOMINEES OF CEDE & CO. OR A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE.

       

      CIGNA CORPORATION

        3.200% Senior Notes Due 2040

        

      

      CUSIP: 125523CJ7

      ISIN: US125523CJ75

        

      

      
        	
                No. [       ]

              	
                Principal Amount  $[        ]

                

              

      

       

      CIGNA CORPORATION, a Delaware corporation (herein called the “Company”), which term includes any successor Person under the Indenture hereinafter referred to, for value received, hereby
        promises to pay to CEDE & CO., or its registered assigns, the principal sum of [___] Million Dollars ($[________]) upon presentation and surrender of this Security on March 15, 2040 and to pay interest thereon accruing from March 16, 2020, or
        from the most recent date to which interest has been paid or duly provided for, semi-annually in arrears on March 15 and September 15 of each year, commencing September 15, 2020, and on the Maturity of this Security (each an “Interest Payment
          Date”), at the rate of 3.200% per annum, until the principal hereof is paid or made available for payment. The amount of interest payable on this Security on any Interest Payment Date shall be computed on the basis of a 360-day year
        consisting of twelve 30-day months. The amount of interest payable for any period shorter than a full monthly period shall be computed on the basis of the actual number of calendar days elapsed in such a period. The interest so payable, and
        punctually paid or duly provided for, on any Interest Payment Date will be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date, which shall be the
        close of business on the date that is 15 calendar days prior to the date on which interest is scheduled to be paid, regardless of whether such date is a Business Day (provided that if this Security is held
        by a securities depositary in book-entry form, the Regular Record Date for this security will be the close of business on the Business Day immediately preceding the date on which interest is scheduled to be paid; provided,
        further, that interest payable on the relevant Maturity will be payable to the Persons to whom the principal of this Security is payable).  If an Interest Payment Date is not a Business Day, then such
        Interest Payment Date shall be the next succeeding Business Day, and no further interest will accrue as a result of such delay. Any such interest not punctually paid or duly provided for on any Interest Payment Date shall forthwith cease to be
        payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such
        Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 calendar days prior to such Special Record Date, or be paid at any time in any other lawful manner not
        inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.

       

      

      
        B-1

        
          

      

      Payment of the principal of (and premium, if any) and interest on this Security will be made at the Corporate Trust Office of the Trustee or the Paying Agent’s office maintained for that purpose in
        the Borough of Manhattan, City of New York, in such coin or currency of the United States of America that at the time of payment is legal tender for payment of public and private debts; provided, however, that at the option of the
        Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.

       

      Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this
        place.

       

      Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the
        Indenture or be valid or obligatory for any purpose.

       

      

      
        B-2

        
          

      

      IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

       

      

      
        	
                 

              	
                
                  
                    CIGNA CORPORATION

                  

                

              
	
                 

              	
                 

              
	
                 

              	
                
                  
                    By:

                  

                

              	 
	
                 

              	
                
                  
                    Name:

                  

                

              	 
	 	
                Title:

              	 

      

       

      

       

      	
              Attest:

            	 
	 	 
	
              Name:

            	
              

              

            
	
              Title:

            	 

       

      

      
        B-3

        
          

      

      TRUSTEE’S CERTIFICATE OF AUTHENTICATION

       

      This is one of the Securities of the series designated under, and referred to in, the within-mentioned Indenture.

       

      

      	

            	
              U.S. BANK NATIONAL ASSOCIATION,

            
	

            	
              as Trustee

            
	 	

            
	

            	
              By:

            	
              

              

            
	 	 	
              Authorized Signatory

            

       

      

      
        B-4

        
          

      

      [REVERSE SIDE OF SECURITY]

        

        CIGNA CORPORATION

        3.200% Senior Notes due 2040

       

      This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more series under an Indenture, dated as of
        September 17, 2018 (the “Base Indenture”), as supplemented by Supplemental Indenture No. 4, dated as of March 16, 2020 (the “Supplemental Indenture” and, together with the Base Indenture, the “Indenture”), between the Company,
        as issuer, and U.S. Bank National Association, as trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto reference is hereby made for a
        statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. 
        This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $750,000,000, subject to future issuances of additional Securities pursuant to Section 3.01 of the Base Indenture.

       

      At any time prior to the Par Call Date (as defined below), the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by
        mail (or as otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed and (ii) the sum
        of the present values of the remaining scheduled payments of principal and interest (excluding interest accrued to the Redemption Date) on the Securities to be redeemed from the Redemption Date to the Par Call Date discounted to the Redemption Date
        on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate, plus 25 basis points, plus accrued and unpaid interest, if any, on the principal amount of the Securities being redeemed to, but excluding,
        the Redemption Date (the “Make Whole Redemption Price”).

       

      At any time on or after the Par Call Date, the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by mail (or as
        otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to 100% of the principal amount of the Securities being redeemed plus accrued and unpaid interest, if any, on the
        principal amount of the Securities being redeemed to, but excluding, the Redemption Date (together with the Make Whole Redemption Price, the “Redemption Price”).

       

      “Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having a maturity comparable to the remaining term of the Securities of
        this series to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Securities of
        this series to be redeemed (assuming, for this purpose, that the Securities of this series mature on the Par Call Date).

       

      

      
        B-5

        
          

      

      “Comparable Treasury Price” means, with respect to any Redemption Date for any Securities of this series, the average of all Reference Treasury Dealer Quotations obtained by the Company.

       

      “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company from time to time.

       

      “Par Call Date” means September 15, 2039 (six months prior to the Stated Maturity of the Securities of this series).

       

      “Primary Treasury Dealer” means a primary U.S. government securities dealer in the United States.

       

      “Reference Treasury Dealer” means each of BofA Securities, Inc., Goldman Sachs & Co. LLC and Morgan Stanley & Co. LLC and their respective successors. If any Reference Treasury
        Dealer ceases to be a Primary Treasury Dealer, the Company will substitute another Primary Treasury Dealer for that dealer.

       

      “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the bid and asked prices
        for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by that Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such
        Redemption Date.

       

      “Treasury Rate” means, with respect to any Redemption Date, (1) the yield, under the heading which represents the average for the immediately preceding week, appearing in the most recently
        published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes yields on actively traded United States Treasury securities
        adjusted to constant maturity under the caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the Stated Maturity for the Securities of this
        series, yields for the two published maturities most closely corresponding to the Comparable Treasury Issue will be determined and the Treasury Rate shall be interpolated or extrapolated from such yields on a straight line basis, rounding to the
        nearest month) or (2) if such release referred to in clause (1) (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per annum equal to the semi-annual equivalent
        yield-to-maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date.

       

      The Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.

       

      Unless the Company defaults in payment of the Redemption Price, interest will cease to accrue on the Securities of this series called for redemption on and after the Redemption Date.  In the event
        of redemption of this Security in part only, a new Security or Securities of this series for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.

       

      

      
        B-6

        
          

      

      Notice of any redemption of the Securities of this series in connection with a transaction or an event may, at the Company’s discretion, be given prior to the completion or the occurrence thereof.
        Any redemption or notice may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to, completion or occurrence of a related transaction or event. At the Company’s discretion, the Redemption Date
        may be delayed until such time as any or all such conditions shall be satisfied, or such redemption may not occur and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the Redemption Date, or
        by the Redemption Date as so delayed.

       

      If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities of this series in full, the Company will make an offer to each Holder (the “Change

          of Control Offer”) of such Securities to repurchase any and all of such Holder’s Securities at a repurchase price in cash equal to 101% of the aggregate principal amount of the Securities of this series repurchased, plus any accrued and
        unpaid interest thereon to, but excluding, date of repurchase (the “Change of Control Payment”).  Within 30 days following any Change of Control Triggering Event, the Company will send a notice to Holders of Securities of this series
        describing the transaction or transactions that constitute the Change of Control Triggering Event and offering to repurchase the Securities of this series on the date specified in the notice, which date will be no less than 15 days and no more than
        60 days from the date such notice is sent (the “Change of Control Payment Date”), pursuant to the procedures required hereby and described in such notice.

       

      The Company will comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations
        thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities of this series as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or
        regulations conflict with the Change of Control repurchase provisions of the Securities of this series, the Company will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the
        Change of Control repurchase provisions of the Securities of this series by virtue of such conflicts.

       

      The Company will not be required to offer to repurchase the Securities of this series upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner,
        at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases on the applicable date all Securities of this series properly tendered and not withdrawn under its offer; provided that for all purposes of the Securities of this series and the Indenture, a failure by such third party to comply with the requirements of such offer and to complete such offer shall be treated as a failure by
        the Company to comply with its obligations to offer to purchase the Securities of this series unless the Company promptly makes an offer to repurchase the Securities of this series at 101% of the principal amount thereof plus accrued and unpaid
        interest, if any, thereon, to, but excluding, to the date of repurchase, which shall be no later than 30 days after the third party’s scheduled Change of Control Payment Date.

       

      

      
        B-7

        
          

      

      On the Change of Control Payment Date, the Company will, to the extent lawful:

       

      
        
          	

                	•	
                  accept or cause a third party to accept for payment all Securities of this series properly tendered pursuant to the Change of Control Offer;

                

        

      

       

      
        
          	

                	•	
                  deposit or cause a third party to deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities of this series properly tendered; and

                

        

      

       

      
        
          	

                	•	
                  deliver or cause to be delivered to the Trustee the Securities of this series properly accepted, together with an Officers’ Certificate stating the principal amount of the Securities of this series being repurchased.

                

        

      

       

      “Below Investment Grade Rating Event” means the Securities of this series are rated below all Investment Grade Ratings by at least two of the three Rating Agencies on any date from the
        earlier of (1) the occurrence of a Change of Control and (2) public notice of the Company’s intention to effect a Change of Control, in each case until the end of the 60-day period following public notice of the occurrence of the Change of Control;
        provided, however, that if (i) during such 60-day period one or more Rating Agencies has publicly announced that it is considering the possible downgrade of the Securities of this series, and
        (ii) a downgrade by each of the Rating Agencies that has made such an announcement would result in a Below Investment Grade Rating Event, then such 60-day period shall be extended for such time as the rating of the Securities of this series by any
        such Rating Agency remains under publicly announced consideration for possible downgrade to a rating below an Investment Grade Rating and a downgrade by such Rating Agency to a rating below an Investment Grade Rating could cause a Below Investment
        Grade Rating Event. Notwithstanding the foregoing, a rating event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a rating
        event for purposes of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Trustee in writing at
        the Company’s or the Trustee’s request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the applicable
        Change of Control has occurred at the time of the rating event).

       

      “Change of Control” means the occurrence of any of the following: (1) direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in
        one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than to the
        Company or one of its subsidiaries; or (2) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
        other than the Company or one of its subsidiaries becomes the beneficial owner, directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s voting stock;  provided, however,
        that a transaction will not be deemed to involve a Change of Control if (A) the Company becomes a wholly owned subsidiary of a holding company and (B)(x) the holders of the voting stock of such holding company immediately following that transaction
        are substantially the same as the holders of the Company’s voting stock immediately prior to that transaction or (y) immediately following that transaction no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) is the beneficial
        owner, directly or indirectly, of more than 50% of the voting stock of such holding company. For purposes of this definition, “voting stock” of a person means capital stock of any class or kind the holders of which are ordinarily, in the
        absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to vote has been suspended by the happening of such a contingency.

       

      

      
        B-8

        
          

      

      “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade Rating Event.

       

       “Fitch” means Fitch Ratings Inc. and any successor to its rating agency business.

       

      “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under a successor rating category of Moody’s), a rating by S&P equal to or higher than
        BBB- (or the equivalent under any successor rating category of S&P), a rating by Fitch equal to or higher than BBB- (or the equivalent under any successor rating category of Fitch), and the equivalent investment grade credit rating from any
        replacement rating agency or rating agencies selected by the Company under the circumstances permitting the Company to select a replacement rating agency and in the manner for selecting a replacement rating agency, in each case as set forth in the
        definition of “Rating Agencies.”

       

      “Moody’s” means Moody’s Investors Service, Inc. and any successor to its rating agency business.

       

      “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any or all of Moody’s, S&P or Fitch ceases to rate the Securities of this series or fails to make a rating of the
        Securities of this series publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that the Company selects (pursuant to a
        resolution of the Company’s Board of Directors) as a replacement rating agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be, with respect to the Securities of this series, as applicable.

       

      “S&P” means Standard & Poor’s Ratings Services, a Standard & Poor’s Financial Services LLC business and any successor to its rating agency business.

       

      If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with
        the effect provided in the Indenture.

       

      The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the
        Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of each
        series to be affected.  The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of
        such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.  Any such consent or waiver by the Holder of this Security shall be conclusive and
        binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this
        Security.

       

      

      
        B-9

        
          

      

      No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Company, or the right of the Holder of this Security, which is
        absolute and unconditional, to pay, or, in the case of the Holder of this Security, to receive payment of, the principal of (and premium, if any) and interest on this Security at the times, place and rate, and in the coin or currency, herein
        prescribed.

       

      As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the Security Register, upon surrender of this Security for
        registration of transfer at the Corporate Trust Office of the Trustee or the Paying Agent’s office where the principal of (and premium, if any) and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of
        transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or such Holder’s attorney duly authorized in writing; and thereupon one or more new Securities of this series and of like tenor, of
        authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.

       

      The Securities of this series are issuable only in fully registered form, without coupons, in denominations of $2,000 and multiples of $1,000 in excess thereof.  As provided in the Indenture and
        subject to certain limitations therein set forth, Securities of this series are exchangeable for other Securities of this series, of a like tenor and aggregate principal amount but of a different authorized denomination, as requested by the Holder
        surrendering the same.

       

      No service charge shall be made for any such registration of transfer or exchange, but the Company or the Trustee may require payment of a sum sufficient to cover any tax or other governmental
        charge that may be imposed in connection with any registration of transfer or exchange of Securities, other than exchanges pursuant to Sections 3.04, 9.06 or 11.07 of the Base Indenture not involving any transfer.

       

      Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is
        registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

       

      The Indenture provides that the Company, at the Company’s option, (a) will be discharged from any and all obligations in respect of the Securities (except for certain obligations to register
        the transfer or exchange of Securities, replace stolen, lost or mutilated Securities, maintain paying agencies and hold moneys for payment in trust) or (b) need not comply with certain restrictive covenants of the Indenture, in each case if
        the Company deposits, in trust with the Trustee, money, or U.S. Government Obligations which through the payment of interest thereon and principal thereof in accordance with their terms will provide money, in an amount sufficient to pay all the
        principal (including any mandatory sinking fund payments) of (and premium, if any) or interest on the Securities on the dates such payments are due in accordance with the terms of such Securities, and certain other conditions are satisfied.

       

      No recourse shall be had for the payment of the principal of or premium, if any, or interest, if any, on this Security, or for any claim based hereon, or otherwise in respect hereof, or based on or
        in respect of the Indenture or any indenture supplemental thereto, against any incorporator, or against any past, present or future stockholder, officer, director, employee, or agent, as such, of the Company or of any successor Person thereof,
        whether by virtue of any law, statute or constitutional provision, or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly waived and released as a condition of, and as
        consideration for, the execution of this Indenture and the issue of the Securities.

       

      If and to the extent that any provision of this Security limits, qualifies or conflicts with a provision of the Indenture, such provision of the Indenture shall control.

       

      All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.

       

      

      
        B-10

        
          

      

       ASSIGNMENT FORM

       

      

      	
              I or we assign and transfer this Security to:

              

            	 

      	 	 
	
              Insert social security or other identifying number of assignee

            	 
	

            
	

            
	
              Print or type name, address and zip code of assignee

            	 
	

            
	

            
	 	 
	
              and irrevocably appoint _______________________, as agent, to transfer this Security on the books of the Company.

            
	 
	
              The agent may substitute another to act for him.

            	 
	 	 

      	
              Date:

              

            	

            	 

      	 	
              Signed

            	

            
	

            	
              (Sign exactly as name appears on the other side of this Security)

            

       

      Signature Guarantee*:

       

      
        
          	*	
                  Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such
                    other “signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

                

           

          

        

      

      
        B-11

        
          

      

      
      ANNEX C

        

          FORM OF 2050 GLOBAL NOTE

       

      UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION, NEW YORK, NEW YORK, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR
        PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
        IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INSOMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST
        HEREIN.

       

      THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE AND IS REGISTERED IN THE NAME OF CEDE & CO.  THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO
        TRANSFERS OF THIS GLOBAL SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN NOMINEES OF CEDE & CO. OR A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE.

       

      CIGNA CORPORATION

        3.400% Senior Notes Due 2050

        

      

      CUSIP: 125523CK4

      ISIN: US125523CK49

        

      

      
        	
                No. [       ]

                

              	
                Principal Amount  $[        ]

              

      

       

      

      CIGNA CORPORATION, a Delaware corporation (herein called the “Company”), which term includes any successor Person under the Indenture hereinafter referred to, for value received, hereby
        promises to pay to CEDE & CO., or its registered assigns, the principal sum of [___] Million Dollars ($[________]) upon presentation and surrender of this Security on March 15, 2050 and to pay interest thereon accruing from March 16, 2020, or
        from the most recent date to which interest has been paid or duly provided for, semi-annually in arrears on March 15 and September 15 of each year, commencing September 15, 2020, and on the Maturity of this Security (each an “Interest Payment
          Date”), at the rate of 3.400% per annum, until the principal hereof is paid or made available for payment. The amount of interest payable on this Security on any Interest Payment Date shall be computed on the basis of a 360-day year
        consisting of twelve 30-day months. The amount of interest payable for any period shorter than a full monthly period shall be computed on the basis of the actual number of calendar days elapsed in such a period. The interest so payable, and
        punctually paid or duly provided for, on any Interest Payment Date will be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date, which shall be the
        close of business on the date that is 15 calendar days prior to the date on which interest is scheduled to be paid, regardless of whether such date is a Business Day (provided that if this Security is held
        by a securities depositary in book-entry form, the Regular Record Date for this security will be the close of business on the Business Day immediately preceding the date on which interest is scheduled to be paid; provided,
        further, that interest payable on the relevant Maturity will be payable to the Persons to whom the principal of this Security is payable).  If an Interest Payment Date is not a Business Day, then such
        Interest Payment Date shall be the next succeeding Business Day, and no further interest will accrue as a result of such delay. Any such interest not punctually paid or duly provided for on any Interest Payment Date shall forthwith cease to be
        payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such
        Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less than 10 calendar days prior to such Special Record Date, or be paid at any time in any other lawful manner not
        inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture.

       

      
        C-1

        
          

      

      Payment of the principal of (and premium, if any) and interest on this Security will be made at the Corporate Trust Office of the Trustee or the Paying Agent’s office maintained for that purpose in
        the Borough of Manhattan, City of New York, in such coin or currency of the United States of America that at the time of payment is legal tender for payment of public and private debts; provided, however, that at the option of the
        Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register.

       

      Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this
        place.

       

      Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the
        Indenture or be valid or obligatory for any purpose.

       

      

      
        C-2

        
          

      

      IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed.

       

      

      
        	
                 

              	
                
                  
                    CIGNA CORPORATION

                  

                

              
	
                 

              	
                 

              
	
                 

              	
                
                  
                    By:

                  

                

              	 
	
                 

              	
                
                  
                    Name:

                  

                

              	 
	 	
                Title:

              	 

      

       

      
        	
                Attest:

                

              	
                 

              
	
                 

              	
                 

              
	
                Name:

                

              	
                 

              
	
                Title:

              	
                 

              

      

       

      

      
        C-3

        
          

      

      TRUSTEE’S CERTIFICATE OF AUTHENTICATION

       

      This is one of the Securities of the series designated under, and referred to in, the within-mentioned Indenture.

       

      

      	

            	
              U.S. BANK NATIONAL ASSOCIATION,

            
	

            	
              as Trustee

            
	 	 	 
	

            	
              By:

            	
              

              

            
	 	 	
              Authorized Signatory

            

       

      

      
        C-4

        
          

      

      [REVERSE SIDE OF SECURITY]

        

        CIGNA CORPORATION

        3.400% Senior Notes due 2050

       

      This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be issued in one or more series under an Indenture, dated as of
        September 17, 2018 (the “Base Indenture”), as supplemented by Supplemental Indenture No. 4, dated as of March 16, 2020 (the “Supplemental Indenture” and, together with the Base Indenture, the “Indenture”), between the Company,
        as issuer, and U.S. Bank National Association, as trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), to which Indenture and all indentures supplemental thereto reference is hereby made for a
        statement of the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. 
        This Security is one of the series designated on the face hereof, initially limited in aggregate principal amount to $1,250,000,000, subject to future issuances of additional Securities pursuant to Section 3.01 of the Base Indenture.

       

      At any time prior to the Par Call Date (as defined below), the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by
        mail (or as otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed and (ii) the sum
        of the present values of the remaining scheduled payments of principal and interest (excluding interest accrued to the Redemption Date) on the Securities to be redeemed from the Redemption Date to the Par Call Date discounted to the Redemption Date
        on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day months) at the Treasury Rate, plus 30 basis points, plus accrued and unpaid interest, if any, on the principal amount of the Securities being redeemed to, but excluding,
        the Redemption Date (the “Make Whole Redemption Price”).

       

      At any time on or after the Par Call Date, the Securities of this series are subject to redemption upon not less than 10 calendar days’ nor more than 60 calendar days’ notice by mail (or as
        otherwise delivered in accordance with the applicable procedures of the Depository), in whole or in part, at a redemption price equal to 100% of the principal amount of the Securities being redeemed plus accrued and unpaid interest, if any, on the
        principal amount of the Securities being redeemed to, but excluding, the Redemption Date (together with the Make Whole Redemption Price, the “Redemption Price”).

       

      “Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having a maturity comparable to the remaining term of the Securities of
        this series to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Securities of
        this series to be redeemed (assuming, for this purpose, that the Securities of this series mature on the Par Call Date).

       

      

      
        C-5

        
          

      

      “Comparable Treasury Price” means, with respect to any Redemption Date for any Securities of this series, the average of all Reference Treasury Dealer Quotations obtained by the Company.

       

      “Independent Investment Banker” means one of the Reference Treasury Dealers appointed by the Company from time to time.

       

      “Par Call Date” means September 15, 2049 (six months prior to the Stated Maturity of the Securities of this series).

       

      “Primary Treasury Dealer” means a primary U.S. government securities dealer in the United States.

       

      “Reference Treasury Dealer” means each of BofA Securities, Inc., Goldman Sachs & Co. LLC and Morgan Stanley & Co. LLC and their respective successors. If any Reference Treasury
        Dealer ceases to be a Primary Treasury Dealer, the Company will substitute another Primary Treasury Dealer for that dealer.

       

      “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the bid and asked prices
        for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by that Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third Business Day preceding such
        Redemption Date.

       

      “Treasury Rate” means, with respect to any Redemption Date, (1) the yield, under the heading which represents the average for the immediately preceding week, appearing in the most recently
        published statistical release designated “H.15” or any successor publication which is published weekly by the Board of Governors of the Federal Reserve System and which establishes yields on actively traded United States Treasury securities
        adjusted to constant maturity under the caption “Treasury Constant Maturities,” for the maturity corresponding to the Comparable Treasury Issue (if no maturity is within three months before or after the Stated Maturity for the Securities of this
        series, yields for the two published maturities most closely corresponding to the Comparable Treasury Issue will be determined and the Treasury Rate shall be interpolated or extrapolated from such yields on a straight line basis, rounding to the
        nearest month) or (2) if such release referred to in clause (1) (or any successor release) is not published during the week preceding the calculation date or does not contain such yields, the rate per annum equal to the semi-annual equivalent
        yield-to-maturity of the Comparable Treasury Issue, calculated using a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date.

       

      The Treasury Rate shall be calculated on the third Business Day preceding the Redemption Date.

       

      Unless the Company defaults in payment of the Redemption Price, interest will cease to accrue on the Securities of this series called for redemption on and after the Redemption Date.  In the event
        of redemption of this Security in part only, a new Security or Securities of this series for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof.

       

      

      
        C-6

        
          

      

      Notice of any redemption of the Securities of this series in connection with a transaction or an event may, at the Company’s discretion, be given prior to the completion or the occurrence thereof.
        Any redemption or notice may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to, completion or occurrence of a related transaction or event. At the Company’s discretion, the Redemption Date
        may be delayed until such time as any or all such conditions shall be satisfied, or such redemption may not occur and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the Redemption Date, or
        by the Redemption Date as so delayed.

       

      If a Change of Control Triggering Event occurs, unless the Company has exercised its right to redeem the Securities of this series in full, the Company will make an offer to each Holder (the “Change

          of Control Offer”) of such Securities to repurchase any and all of such Holder’s Securities at a repurchase price in cash equal to 101% of the aggregate principal amount of the Securities of this series repurchased, plus any accrued and
        unpaid interest thereon to, but excluding, date of repurchase (the “Change of Control Payment”).  Within 30 days following any Change of Control Triggering Event, the Company will send a notice to Holders of Securities of this series
        describing the transaction or transactions that constitute the Change of Control Triggering Event and offering to repurchase the Securities of this series on the date specified in the notice, which date will be no less than 15 days and no more than
        60 days from the date such notice is sent (the “Change of Control Payment Date”), pursuant to the procedures required hereby and described in such notice.

       

      The Company will comply with the requirements of Rule 14e-1 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and any other securities laws and regulations
        thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Securities of this series as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or
        regulations conflict with the Change of Control repurchase provisions of the Securities of this series, the Company will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the
        Change of Control repurchase provisions of the Securities of this series by virtue of such conflicts.

       

      The Company will not be required to offer to repurchase the Securities of this series upon the occurrence of a Change of Control Triggering Event if a third party makes such an offer in the manner,
        at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases on the applicable date all Securities of this series properly tendered and not withdrawn under its offer; provided that for all purposes of the Securities of this series and the Indenture, a failure by such third party to comply with the requirements of such offer and to complete such offer shall be treated as a failure by
        the Company to comply with its obligations to offer to purchase the Securities of this series unless the Company promptly makes an offer to repurchase the Securities of this series at 101% of the principal amount thereof plus accrued and unpaid
        interest, if any, thereon, to, but excluding, to the date of repurchase, which shall be no later than 30 days after the third party’s scheduled Change of Control Payment Date.

       

      

      
        C-7

        
          

      

      On the Change of Control Payment Date, the Company will, to the extent lawful:

       

      
        
          	

                	•	
                  accept or cause a third party to accept for payment all Securities of this series properly tendered pursuant to the Change of Control Offer;

                

        

      

       

      
        
          	

                	•	
                  deposit or cause a third party to deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Securities of this series properly tendered; and

                

        

      

       

      
        
          	

                	•	
                  deliver or cause to be delivered to the Trustee the Securities of this series properly accepted, together with an Officers’ Certificate stating the principal amount of the Securities of this series being repurchased.

                

        

      

       

      “Below Investment Grade Rating Event” means the Securities of this series are rated below all Investment Grade Ratings by at least two of the three Rating Agencies on any date from the
        earlier of (1) the occurrence of a Change of Control and (2) public notice of the Company’s intention to effect a Change of Control, in each case until the end of the 60-day period following public notice of the occurrence of the Change of Control;
        provided, however, that if (i) during such 60-day period one or more Rating Agencies has publicly announced that it is considering the possible downgrade of the Securities of this series, and
        (ii) a downgrade by each of the Rating Agencies that has made such an announcement would result in a Below Investment Grade Rating Event, then such 60-day period shall be extended for such time as the rating of the Securities of this series by any
        such Rating Agency remains under publicly announced consideration for possible downgrade to a rating below an Investment Grade Rating and a downgrade by such Rating Agency to a rating below an Investment Grade Rating could cause a Below Investment
        Grade Rating Event. Notwithstanding the foregoing, a rating event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a rating
        event for purposes of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Trustee in writing at
        the Company’s or the Trustee’s request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the applicable
        Change of Control has occurred at the time of the rating event).

       

      “Change of Control” means the occurrence of any of the following: (1) direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in
        one or a series of related transactions, of all or substantially all of the properties or assets of the Company and its subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than to the
        Company or one of its subsidiaries; or (2) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
        other than the Company or one of its subsidiaries becomes the beneficial owner, directly or indirectly, of more than 50% of the then outstanding number of shares of the Company’s voting stock;  provided, however,
        that a transaction will not be deemed to involve a Change of Control if (A) the Company becomes a wholly owned subsidiary of a holding company and (B)(x) the holders of the voting stock of such holding company immediately following that transaction
        are substantially the same as the holders of the Company’s voting stock immediately prior to that transaction or (y) immediately following that transaction no “person” (as that term is used in Section 13(d)(3) of the Exchange Act) is the beneficial
        owner, directly or indirectly, of more than 50% of the voting stock of such holding company. For purposes of this definition, “voting stock” of a person means capital stock of any class or kind the holders of which are ordinarily, in the
        absence of contingencies, entitled to vote for the election of directors (or persons performing similar functions) of such person, even if the right to vote has been suspended by the happening of such a contingency.

       

      

      
        C-8

        
          

      

      “Change of Control Triggering Event” means the occurrence of both a Change of Control and a Below Investment Grade Rating Event.

       

       “Fitch” means Fitch Ratings Inc. and any successor to its rating agency business.

       

      “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under a successor rating category of Moody’s), a rating by S&P equal to or higher than
        BBB- (or the equivalent under any successor rating category of S&P), a rating by Fitch equal to or higher than BBB- (or the equivalent under any successor rating category of Fitch), and the equivalent investment grade credit rating from any
        replacement rating agency or rating agencies selected by the Company under the circumstances permitting the Company to select a replacement rating agency and in the manner for selecting a replacement rating agency, in each case as set forth in the
        definition of “Rating Agencies.”

       

      “Moody’s” means Moody’s Investors Service, Inc. and any successor to its rating agency business.

       

      “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any or all of Moody’s, S&P or Fitch ceases to rate the Securities of this series or fails to make a rating of the
        Securities of this series publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of Section 3(a)(62) of the Exchange Act that the Company selects (pursuant to a
        resolution of the Company’s Board of Directors) as a replacement rating agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be, with respect to the Securities of this series, as applicable.

       

      “S&P” means Standard & Poor’s Ratings Services, a Standard & Poor’s Financial Services LLC business and any successor to its rating agency business.

       

      If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with
        the effect provided in the Indenture.

       

      The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the
        Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of not less than a majority in aggregate principal amount of the Securities at the time Outstanding of each
        series to be affected.  The Indenture also contains provisions permitting the Holders of specified percentages in aggregate principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of
        such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.  Any such consent or waiver by the Holder of this Security shall be conclusive and
        binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this
        Security.

       

      

      
        C-9

        
          

      

      No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Company, or the right of the Holder of this Security, which is
        absolute and unconditional, to pay, or, in the case of the Holder of this Security, to receive payment of, the principal of (and premium, if any) and interest on this Security at the times, place and rate, and in the coin or currency, herein
        prescribed.

       

      As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security is registrable in the Security Register, upon surrender of this Security for
        registration of transfer at the Corporate Trust Office of the Trustee or the Paying Agent’s office where the principal of (and premium, if any) and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of
        transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or such Holder’s attorney duly authorized in writing; and thereupon one or more new Securities of this series and of like tenor, of
        authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.

       

      The Securities of this series are issuable only in fully registered form, without coupons, in denominations of $2,000 and multiples of $1,000 in excess thereof.  As provided in the Indenture and
        subject to certain limitations therein set forth, Securities of this series are exchangeable for other Securities of this series, of a like tenor and aggregate principal amount but of a different authorized denomination, as requested by the Holder
        surrendering the same.

       

      No service charge shall be made for any such registration of transfer or exchange, but the Company or the Trustee may require payment of a sum sufficient to cover any tax or other governmental
        charge that may be imposed in connection with any registration of transfer or exchange of Securities, other than exchanges pursuant to Sections 3.04, 9.06 or 11.07 of the Base Indenture not involving any transfer.

       

      Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is
        registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary.

       

      The Indenture provides that the Company, at the Company’s option, (a) will be discharged from any and all obligations in respect of the Securities (except for certain obligations to register
        the transfer or exchange of Securities, replace stolen, lost or mutilated Securities, maintain paying agencies and hold moneys for payment in trust) or (b) need not comply with certain restrictive covenants of the Indenture, in each case if
        the Company deposits, in trust with the Trustee, money, or U.S. Government Obligations which through the payment of interest thereon and principal thereof in accordance with their terms will provide money, in an amount sufficient to pay all the
        principal (including any mandatory sinking fund payments) of (and premium, if any) or interest on the Securities on the dates such payments are due in accordance with the terms of such Securities, and certain other conditions are satisfied.

       

      No recourse shall be had for the payment of the principal of or premium, if any, or interest, if any, on this Security, or for any claim based hereon, or otherwise in respect hereof, or based on or
        in respect of the Indenture or any indenture supplemental thereto, against any incorporator, or against any past, present or future stockholder, officer, director, employee, or agent, as such, of the Company or of any successor Person thereof,
        whether by virtue of any law, statute or constitutional provision, or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being expressly waived and released as a condition of, and as
        consideration for, the execution of this Indenture and the issue of the Securities.

       

      If and to the extent that any provision of this Security limits, qualifies or conflicts with a provision of the Indenture, such provision of the Indenture shall control.

       

      All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.

       

      

      
        C-10

        
          

      

      ASSIGNMENT FORM

       

      

      	
              I or we assign and transfer this Security to:

              

            	 

      	 	 
	
              Insert social security or other identifying number of assignee

            
	

            
	 	 
	
              Print or type name, address and zip code of assignee

            	 
	

            
	

            
	 	 
	
              and irrevocably appoint _______________________, as agent, to transfer this Security on the books of the Company.

            
	 	 
	
              The agent may substitute another to act for him.

            	 
	 	 

      	
              Date:

              

            	 	 

      	 	 
	

            	
              
                Signed

              

            	 
	
              

              

            	
              (Sign exactly as name appears on the other side of this Security)

            

       

      Signature Guarantee*:

       

      
        
          	*	
                  Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Registrar, which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such
                    other “signature guarantee program” as may be determined by the Registrar in addition to, or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended.

                

        

      

      

      

      

      

      
        C-11

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