Document:

Exhibit 4.66

 

 

THIS NOTE (THE “NOTE”) HAS NOT BEEN REGISTERED UNDER
THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED, SOLD, PLEDGED OR
OTHERWISE TRANSFERRED EXCEPT PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT AND IN ACCORDANCE WITH
ALL APPLICABLE SECURITIES LAWS OF THE STATES OF THE UNITED STATES AND OTHER JURISDICTIONS.

 

AMYRIS, INC.

 

NOTE 

 

	No. A-1	 	$25,000,000

 

  Amyris, Inc., a Delaware corporation (the “Company”),
for value received, hereby promises to pay to WUTIAN SUPPLY CHAIN CORPORATION LIMITED, or registered assigns (“Holder”),
the principal sum of hereof, which shall be no more than Twenty-Five Million Dollars ($25,000,000), no later than December 31,
20121 and to pay interest thereon, from the date of each Note, or from the most recent interest payment date to which interest
has been paid on such Note, quarterly on March 31, June 30, September 30 and December 31 in each year, commencing March 31, 2017,
at the rate of 2.5% per quarter (calculated on a simple interest basis) until the principal hereof is due and in the manner set
forth below.

 

    Payment of the principal of this Note
shall be made upon the surrender of this Note to the Company, at its chief executive office (or such other office within the United
States as shall be designated by the Company to the holder hereof) (the “Designated Office”), in such coin or
currency of the United States of America as at the time of payment shall be legal tender for the payment of public and private
debts. Payment of interest in cash and all other amounts payable in cash with respect to this Note shall be made by wire transfer
to the holder, provided that if the holder shall not have furnished wire instructions in writing to the Company
no later than the business day immediately prior to the date on which the Company makes such payment, such payment may be made
by U.S. dollar check mailed to the address of the Person entitled thereto as such address shall appear in the Company security
register.

 

Capitalized terms used and not otherwise
defined herein shall have the respective meanings given to those terms in Section 4 hereof.

 

    1.  Redemption.  This
Note is subject to redemption, as a whole or from time to time in part (in any amount that is an integral multiple of $1,000),
upon not less than five (5) days’ prior written notice in the manner provided in Section 5(b) hereof , at the election of
the Company, at a redemption price of 100% of the principal amount hereof, together with accrued interest to the redemption date,
but interest installments whose stated maturity is on or prior to such redemption date will be payable to the holder of this Note,
or one or more predecessor Securities, of record at the close of business on the relevant record dates referred to on the face
hereof.

 

    2.  Certain Covenants.
Until the Obligations hereunder are paid in full:

 

		(a)	The Company will maintain or cause to be maintained its and each of its Subsidiaries' corporate or other organizational existence
and good standing in its jurisdiction of incorporation and maintain its qualification in each jurisdiction where the failure to
so qualify would reasonably be expected to have a Material Adverse Effect.

 

		(b)	The Company will, and will cause each of its Subsidiaries to, comply with all applicable statutes, regulation and orders of,
and all applicable restrictions imposed by, all governmental bodies, domestic or foreign, in respect of the conduct of its business
and the ownership of its property, other than those the noncompliance with which would not have, and which would not reasonably
be expected to have, a Material Adverse Effect.

 

     

     

    

 

The Company will pay and discharge, and will cause
each of its Subsidiaries to pay and discharge, all taxes, assessments and governmental charges or levies imposed upon it or upon
its income or profits, or upon any properties belonging to it and all lawful claims which, if unpaid, might become a Lien upon
any properties of the Company or any of its Subsidiaries; provided that, neither the Company nor any of its Subsidiaries shall
be required to pay any such tax, assessment, charge, levy or claim which is being contested in good faith and by proper proceedings
if it has maintained adequate reserves with respect thereto in accordance with GAAP.

 

		(c)	The Company will, and will cause each of its Subsidiaries to, (A) maintain insurance coverage by such insurers and in such
forms and amounts and against such risks as are customarily carried by persons conducting businesses similar to those of the Company
and its Subsidiaries and (B) promptly upon the holder's request, furnish to the holder such information about such insurance as
the holder may from time to time reasonably request, which information shall be prepared in form and detail satisfactory to the
holder.

 

		(d)	Neither the Company nor any of its Subsidiaries shall (i) pay any dividends or make any distributions on its Equity Securities
other than dividends paid on the Common Stock paid solely in Common Stock; (ii) purchase redeem, retire, defease or otherwise acquire
for value any of its Equity Securities; (iii) return any capital to any holder of its Equity Securities; (iv) make any distribution
of assets, Equity Securities, obligations or securities to any holder of its Equity Securities; or (v) set apart any sum for any
such purpose; provided that any Subsidiary may pay cash dividends to the Company.

 

		(e)	Neither the Company nor any of its Subsidiaries shall make any payment or distribution in cash to any stockholder or Affiliate
of the Company other than payments or distributions made in the ordinary course of business.

 

    3.  Events of Default.  

 

(a)     “Event
of Default”, wherever used herein, means any one of the following events (whatever the reason for such Event of Default
and whether it shall be voluntary or involuntary or be effected by operation of law or pursuant to any judgment, decree or order
of any court or any order, rule or regulation of any administrative or governmental body):

 

	 	(i)	default in the payment of any principal upon this Note when it becomes due and payable, following a 10 day cure period; or
	 	 	 
	 	(ii)	default in the payment of any interest upon this Note when it becomes due and payable for a cure period of ten (10) days after notice; or
	 	 	 
	 	(iii)	the Company and/or the Company’s business partner, directly or indirectly, sells farnesene for purpose of Vitamin E production to any other vitamin E, or vitamin E ingredients, manufacturer other than Nenter & Co., Inc. (“Nenter”); or

 

		(iv)	the Company and/or its subsidiary(ies) and/or the Company’s qualified third-party contract manufacturer fail more than
two times in any calendar year to satisfy the quantity demand (exceeding a 5% order quantity variance) of Farnesene from Nenter
as required by Section 2.3 of the Renewable Farnesene Supply Agreement between the Company and Nenter dated April 26, 2016, including
but not limited to the suspension or discontinue of such supply, and subject to Force Majeure, Section 8.9; provided such supply
quantity is communicated to Amyris by Nenter 90 days before issuing the purchase order, the delivery date is reasonable for the
amount of Farnesene, and that Nenter is not in default under the Supply Agreement.

 

    	 	2	 

     

    

 

		(b)	default in the performance, or breach, of any covenant of the Company herein (other than a default in the performance or breach
of which is specifically dealt with elsewhere in this Section 3(a)) and continuance of such default or breach for a period of 45
days after there has been given, in the manner set forth in Section 5(b), to the Company by the holder of this Note a written notice
specifying such default or breach and requiring it to be remedied and stating that such notice is a "Notice of Default"
hereunder;

 

		(c)	the entry by a court having jurisdiction in the premises of (x) a decree or order for relief in respect of the Company or any
Significant Subsidiary (as defined below) in an involuntary case or proceeding under any applicable Federal or state bankruptcy,
insolvency, reorganization or other similar law or (y) a decree or order approving as properly filed a petition seeking reorganization,
arrangement, adjustment or composition of or in respect of the Company or any Subsidiary under any applicable Federal or state
law, or appointing a custodian, receiver, liquidator, assignee, trustee, sequestrator or other similar official of the Company
or any Significant Subsidiary or of any substantial part of its or their respective property, or ordering the winding up or liquidation
of its affairs, and the continuance of any such decree or order for relief or any such other decree or order unstayed and in effect
for a period of 60 consecutive days;

 

		(d)	the commencement by the Company or any Significant Subsidiary of a voluntary case or proceeding under any applicable Federal
or state bankruptcy, insolvency, reorganization or other similar law or of any other case or proceeding to be adjudicated a bankrupt
or insolvent, or the consent by the Company or any Significant Subsidiary to the entry of a decree or order for relief in respect
of the Company or any Significant Subsidiary in an involuntary case or proceeding under any applicable Federal or state bankruptcy,
insolvency, reorganization or other similar law or to the commencement of any bankruptcy or insolvency case or proceeding against
either the Company or a Significant Subsidiary, or the filing by either the Company or a Significant Subsidiary of a petition or
answer or consent seeking reorganization or similar relief under any applicable Federal or state law, or the consent by it to the
filing of such petition or to the appointment of or taking possession by a custodian, receiver, liquidator, assignee, trustee,
sequestrator or other similar official of the Company or any Significant Subsidiary or of any substantial part of the property
of either the Company or any Significant Subsidiary, or the making by either the Company or any Significant Subsidiary of an assignment
for the benefit of creditors, or the admission by either the Company or any Significant Subsidiary in writing of its inability
to pay its debts generally as they become due, or the taking of corporate action by the Company or any Significant Subsidiary in
furtherance of any such action; or

 

		(e)	The Company will give the holder of this Note notice, within two Trading Days of the occurrence thereof, of any Event of Default or
any event that, with the giving of notice or passage of time or both, would become an Event of Default. Such notice shall be given
in the manner provided in Section 5(b).

 

		(f)	At any time when the holder of this Note may exercise its rights under this Section 3 with respect to an Event of Default, the
Company shall provide the holder within three (3) business days such information as the holder may reasonably request to establish
any assertion by the Company under this Section 3(h).

 

		(g)	Remedy for Specified Defaults. If an Event of Default specified in Section 3(a)(i) or 3(a)(ii) or 3(a) (iii) or 3(a)(iv)
occurs, the Company shall grant to Nenter the global exclusive license for the Intellectual Property specified in Schedule I of
the Credit Agreement for the production of Vitamin E with no charges or royalties, including the latest necessary fermentation,
strain related technical indices, processes, drawings, technical information, specifications and free technical service to ensure
Nenter will be capable of manufacturing farnesene independently by itself through the use of such Intellectual Property.

 

    	 	3	 

     

    

 

For the avoidance of doubt,
failure or delay to give Notice of Default by the Lender to the Company does not construed as any waive for remedies for the Lender,
and does not make the Company exempt from its default responsibilities.

 

		(h)	Additionally Remedy for Non-Payment Defaults. Subject to applicable law, upon the occurrence of a Payment Default (as
defined below), the Company shall be required to repay the entire unpaid principal amount of this Note and all accrued and unpaid
interest hereon in the form of such number of fully paid and nonassessable shares of Common Stock (as defined below) (calculated
to the nearest 1/100 of a share) as may be determined by dividing such unpaid principal amount and accrued and unpaid interest
by the Share Repayment Price (as defined below). For the avoidance of doubt, the Company shall not be required to register such
Common Stock under the Securities Act.

 

		(i)	The Company shall not issue any shares of Common Stock pursuant to the terms of this Note if the issuance of such shares of
Common Stock (taken together with the issuance of all other shares of Common Stock pursuant to the terms of the Notes) would exceed
the aggregate number of shares of Common Stock which the Company may issue pursuant to the terms of the Notes without breaching
the Company’s obligations under the rules or regulations of the Nasdaq National Market, except that such limitation shall
not apply in the event that the Company obtains the approval of its stockholders as required by the applicable rules of the Nasdaq
National Market for issuances of shares of Common Stock in excess of such amount.

 

 

        4.  Definitions.  Capitalized
terms used in this Note and not otherwise defined have the meanings given to them in the Credit Agreement. Unless otherwise defined
in this Note, the following capitalized terms shall have the following respective meanings when used herein:

 

“Affiliate” of any specified
Person means any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with
such specified Person. For the purposes of this definition, “control”, when used with respect to any specified Person,
means the power to direct the management and policies of such Person, directly or indirectly, whether through the ownership of
voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings
correlative to the foregoing.

 

“Common Stock” means
the Common Stock, par value $0.0001 per share, of the Company authorized at the date of this instrument as originally executed.
Subject to the provisions of Section 3, shares issuable on repayment of the Notes or repurchase of this Note shall include only
Common Stock or shares of any class or classes of common stock resulting from any reclassification or reclassifications thereof; provided, however,
that if at any time there shall be more than one such resulting class, the shares so issuable on repayment of this Note shall include
shares of all such classes, and the shares of each such class then so issuable shall be substantially in the proportion which the
total number of shares of such class resulting from all such reclassifications bears to the total number of shares of all such
classes resulting from all such reclassifications.

 

“Company Average Trading Price”
shall mean the volume weighted average closing sale price of one share of Common Stock for the ninety (90) consecutive Trading
Days ending on (and including) the Trading Day that is two (2) Trading Days immediately preceding the Payment Default (as adjusted
as appropriate to reflect any stock splits, stock dividends, combinations, reorganizations, reclassifications or similar events).

 

“Credit Agreement” means
the Credit Agreement, dated as of October 26, 2016, entered into by and between the Company and Guanfu.

 

“Equity Securities” of any Person means
(a) all common stock, preferred stock, participations, shares, partnership interests or other equity interests in and of such Person
(regardless of how designated and whether or not voting or non-voting) and (b) all warrants, options and other rights to acquire
any of the foregoing.

 

    	 	4	 

     

    

 

“GAAP” means generally accepted accounting principles as in effect in the United States of America from
time to time.

 

“Guanfu” means Guanfu Holding Co.,
Ltd., a company duly established and validly existing under the laws of the People’s Republic of China. In order to fulfill
this Note and Credit Agreement, Guanfu is about to make its subsidiary be the entity to accomplish the obligations and as the Holder,
so “Guanfu” refers to “Guanfu or its subsidiary”.

 

“Payment Default” means
an Event of Default specified in Section 3(a)(i) or 3(a)(ii).

 

“Person” shall mean and
include an individual, a partnership, a corporation (including a business trust), a joint stock company, a limited liability company,
an unincorporated association, a joint venture or other entity or a governmental authority.

 

“Share Repayment Price”
on any day shall equal ninety percent (90%) of the Company Average Trading Price.

 

“Significant Subsidiary”
means, with respect to any Person, a Subsidiary of such Person that would constitute a significant subsidiary” as such term
is defined under Rule 1-02 of Regulation S-X of the Commission.

 

“Subsidiary” shall mean
(a) any corporation of which more than 50% of the issued and outstanding equity securities having ordinary voting power to elect
a majority of the board of directors of such corporation is at the time directly or indirectly owned or controlled by the Company,
(b) any partnership, joint venture, limited liability company or other association of which more than 50% of the equity interests
having the power to vote, direct or control the management of such partnership, joint venture, limited liability company or other
association is at the time directly or indirectly owned and controlled by the Company, and (c) any other entity included in the
financial statements of the Company on a consolidated basis.

 

“Trading Day” means (i)
if the Common Stock is admitted to trading on the Nasdaq National Market or any other system of automated dissemination of quotations
of securities prices, a day on which trades may be effected through such system; (ii) if the Common Stock is listed or admitted
for trading on the New York Stock Exchange or any other national securities exchange, a day on which such exchange is open for
business; or (iii) if the Common Stock is not admitted to trading on the Nasdaq National Market or listed or admitted for trading
on any national securities exchange or any other system of automated dissemination of quotation of securities prices, a day on
which the Common Stock is traded regular way in the over-the-counter market and for which a closing bid and a closing asked price
for the Common Stock are available.

 

    5.  Other.  

 

    (a) No provision of this Note shall
alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and interest, if any,
on this Note at the times, places and rate, and in the coin or currency, herein prescribed or to repay this Note as herein provided.

 

    (b) The Company will give prompt
written notice to the holder of this Note of any change in the location of the Designated Office. Any notice to the Company or
to the holder of this Note shall be given in the manner set forth in the Credit Agreement.

 

    (c) The transfer of this Note is
registrable on the register maintained by the Company upon surrender of this Note for registration of transfer at the Designated
Office, duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company duly executed
by, the holder hereof or such holder’s attorney duly authorized in writing, and thereupon one or more new Securities, of
authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees.
Such Securities are issuable only in registered form without coupons in denominations of $1,000 and any integral multiple thereof.
No service

 

    	 	5	 

     

    

 

charge shall be made for any such registration of transfer, but the Company may require payment of a sum sufficient to recover
any tax or other governmental charge payable in connection therewith. Prior to due presentation of this Note for registration of
transfer, the Company and any agent of the Company may treat the Person in whose name this Note is registered as the owner thereof
for all purposes, whether or not this Note be overdue, and neither the Company nor any such agent shall be affected by notice to
the contrary.

 

    (d) This Note shall be governed
by and construed in accordance with the internal laws of the State of Delaware, United States of America, without regard to principles
of conflicts of laws.

 

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left blank]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	6	 

     

    

 

    IN WITNESS WHEREOF, the Company has
caused this Note to be duly executed.

 

Dated: December 31, 2016

 

	 	Amyris, Inc.	 
	 	 	 	 
	 	By:	/s/  John Melo	 
	 	 	 	 
	 	Name:	John Melo	 
	 	Title:	President and Chief Executive Officer

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

7Exhibit 4.67

 

Note pUrchase AGREEMENT

 

This Note Purchase Agreement (this “Agreement”)
is made as of October 27, 2016 (the “Effective Date”) by and among Amyris, Inc., a Delaware corporation (the
“Company”), and the individuals or entities listed on Schedule I hereto (each, a “Purchaser,”
and collectively, the “Purchasers”).

 

Preliminary Statement

 

Subject to the terms and conditions hereof,
each Purchaser desires to purchase, and the Company desires to offer and sell to each Purchaser, that aggregate principal amount
of Secured Promissory Notes with a principal amount set forth opposite each such Purchaser’s name on Schedule I hereto
(which aggregate principal amount for all Purchasers as of the Closing (as defined below) shall be $8,500,000) (each such Secured
Promissory Note, a “Note” and collectively, the “Notes”). If and when issued, each of the
Notes shall be evidenced by a promissory note in the form attached hereto as Exhibit A.

 

Agreement

 

The parties, intending to be legally bound, agree as follows:

 

1.     
Sale of Notes. Subject to the terms and conditions hereof, at the Closing (as defined in Section 2),
the Company shall sell to each Purchaser, and, subject to satisfaction of the conditions set forth in this Agreement, each such
Purchaser will purchase from the Company, (i) a Note in a principal amount as set forth next to such Purchaser’s name on
Schedule I hereto for a purchase price equal to the purchase price set forth next to such Purchaser’s name on Schedule
I hereto under the column “Note Purchase Price” (the “Purchase Price”). The sale and purchase
of the Notes to each Purchaser shall constitute a separate sale and purchase hereunder.

 

2.     
Closing. The closing (“Closing”) of the transactions contemplated hereby shall be
held at the offices of Fenwick & West LLP, 801 California Street, Mountain View, California 94041 within one business day following
the date on which the last of the conditions set forth in Sections 7 and 8 have been satisfied or waived in accordance with this
Agreement but in no event later than October 31, 2016 (such date, the “Closing Date”), or at such other time
and place as the Company and the Purchasers mutually agree upon.

 

3.     
Delivery.

 

(a)        
At the Closing, each Purchaser shall (i) pay the Company the applicable Purchase Price in immediately available funds, or
(ii) (A) initiate irrevocable payment instructions to its paying bank to make the payment (an “Irrevocable Payment Instruction”)
to the Company of the applicable Purchase Price in immediately available funds and (B) deliver to the Company confirmation that
such Purchaser has made an Irrevocable Payment Instruction, such confirmation to be in the form of a federal reference number or
other similar written evidence that a wire has been initiated.

 

     

     

    

 

(b)        
At the Closing, or, if applicable, upon receipt of the applicable amount of the Purchase Price due in respect of the Closing
from any Purchaser who makes an Irrevocable Payment Instruction at the Closing, the Company shall deliver to such Purchaser a Note
with a principal amount as provided in Section 1 above, such Note to be registered in the name of such Purchaser, or in such nominee’s
or nominees’ name(s) as provided by such Purchaser to the Company, against payment of the Purchase Price therefor as provided
in Section 1 above by wire transfer of immediately available funds to such account or accounts as the Company shall designate
in writing to such Purchaser at least two (2) days prior to the date of the Closing.

 

4.     
Company Representations. The Company represents and warrants to the Purchasers as follows:

 

(a)        
Organization and Standing. The Company is duly incorporated, validly existing, and in good standing under the laws
of the State of Delaware. The Company has all requisite power and authority to own and operate its properties and assets and to
carry on its business as presently conducted and as proposed to be conducted. The Company is qualified to do business as a foreign
entity in every jurisdiction in which the failure to be so qualified would have, or would reasonably be expected to have, a material
adverse effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations,
prospects, financial condition or results of operation of the Company or the ability of the Company to perform its obligations
under this Agreement (a “Material Adverse Effect”). For the purposes of clarity, the implementation of any plan
for the significant restructuring of the Company, which has been approved by the Board of Directors of the Company as of the date
hereof, shall not constitute a Material Adverse Effect.

 

(b)        
Power. The Company has all requisite power to execute and deliver this Agreement, to sell and issue the Notes hereunder,
and to carry out and perform its obligations under the terms of this Agreement and the Notes (collectively, the “Transaction
Agreements”).

 

(c)               
Authorization. Subject to any waivers of covenants limiting the Company’s ability to incur further debt under
outstanding debt instruments and loans, each of which would be obtained or waived as required prior to the Closing (the “Pre-Closing
Consents”), the execution, delivery, and performance of the Transaction Agreements by the Company has been duly authorized
by all requisite action on the part of the Company and its officers, directors and stockholders, and this Agreement and the Notes
constitute the legal, valid, and binding obligation of the Company enforceable in accordance with its terms, except (a) as limited
by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of
creditors’ rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive
relief or other equitable remedies (together, the “Enforceability Exceptions”).

 

(d)        
Consents and Approvals. Except for any Current Report on Form 8-K or other document to be filed by the Company with
the U.S. Securities and Exchange Commission (the “SEC”) in connection with the transactions contemplated hereby,
the Company is not required to give any notice to, make any filing with, or obtain any authorization, consent, or approval of any
government or governmental agency in order to consummate the transactions contemplated hereby. Assuming the accuracy of the representations
of the Purchasers in Section 5, no consent,

 

    	 	2	 

     

    

 

approval, authorization or other order of, or
registration, qualification or filing with, any court, regulatory body, administrative agency, self-regulatory organization, stock
exchange or market (including The NASDAQ Stock Market LLC (“The NASDAQ Stock Market”), or other governmental
body is required for the execution and delivery of the Transaction Agreements, the valid issuance, sale and delivery of the Notes
to be sold pursuant to this Agreement other than such as have been made or obtained, or for any securities filings required to
be made under federal or state securities laws applicable to the offering of the Notes.

 

(e)        
Non-Contravention. The execution and delivery of this Agreement and, following satisfaction of the Closing conditions
set forth in Sections 7 and 8 hereof as applicable to the Closing, the issuance, sale and delivery of the Notes to be sold by the
Company under this Agreement and the performance by the Company of its obligations under the Transaction Agreements and/or the
consummation of the transactions contemplated thereby, will not (a) conflict with, result in the breach or violation of, or
constitute (with or without the giving of notice or the passage of time or both) a violation of, or default under, (i) subject
to obtaining the Pre-Closing Consents, any bond, debenture, note or other evidence of indebtedness, or under any lease, license,
franchise, permit, indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which
the Company or any subsidiary is a party or by which it or its properties may be bound or affected, (ii) the Company’s
Restated Certificate of Incorporation, as amended and as in effect on the date hereof, the Company’s Bylaws, as amended and
as in effect on the date hereof, or the equivalent document with respect to any subsidiary, as amended and as in effect on the
date hereof, or (iii) any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental
or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company,
any of its subsidiaries or their respective properties, except in the case of clauses (i) and (iii) for such conflicts,
breaches, violations or defaults that would not be likely to have, individually or in the aggregate, a Material Adverse Effect,
or (b) except for any security interests granted pursuant to the Notes, result in the creation or imposition of any lien,
encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of the Company or
any of its subsidiaries or an acceleration of indebtedness pursuant to any obligation, agreement or condition contained in any
material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any
other agreement or instrument to which the Company or any if its subsidiaries is a party or by which the Company or any of its
subsidiaries is bound or to which any of the property or assets of the Company is subject. For purposes of this Section 4(e), the
term “material” shall apply to agreements, understandings, instruments, contracts or proposed transactions to which
the Company is a party or by which it is bound involving obligations (contingent or otherwise) of, or payments to, the Company
in excess of $100,000 in a 12-month period.

 

(f)         
Notes. The Notes have been duly authorized by the Company and, when duly executed and delivered and paid for as provided
herein, will be duly and validly issued and outstanding and will constitute valid and legally binding obligations of the Company
enforceable against the Company in accordance with their terms, subject to the Enforceability Exceptions. The issuance and delivery
of each of the Notes is not subject to preemptive, co-sale, right of first refusal or any other similar rights of the stockholders
of the Company or any other person, or any liens or encumbrances or result in the triggering of any anti-dilution or other similar
rights under any outstanding securities of the Company.

 

    	 	3	 

     

    

 

(g)        
No Registration. Assuming the accuracy of each of the representations and warranties of the Purchaser herein, the
issuance by the Company of the Notes is exempt from registration under the Securities Act of 1933, as amended (the “Securities
Act”).

 

(h)        
Reporting Status. The Company is subject to the reporting requirements of the Securities Exchange Act of 1934, as
amended (the “Exchange Act”), and, as of the Closing, will have filed all documents and reports that the Company
was required to file pursuant to Section I.A.3.b of the General Instructions to Form S-3 promulgated under the Securities Act in
order for the Company to be eligible to use Form S-3 (the foregoing materials, together with any materials filed by the Company
under the Exchange Act, whether or not required, collectively, the “SEC Documents”). The SEC Documents complied
as to form in all material respects with requirements of the Securities Act and Exchange Act and the rules and regulations of the
SEC promulgated thereunder (collectively, the “SEC Rules”), and none of the SEC Documents and the information
contained therein, as of their respective filing dates, contained any untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances
under which they were made, not misleading. As used in this Agreement, “Previously Disclosed” means information
set forth in or incorporated by reference into the SEC Documents filed with the SEC on or after November 9, 2015 but prior to the
date hereof (except for risks and forward-looking information set forth in the “Risk Factors” section of the applicable
SEC Documents or in any forward-looking statement disclaimers or similar statements that are similarly non-specific and are predictive
or forward-looking in nature).

 

(i)         
Legal Proceedings. Except as Previously Disclosed, there is no action, suit or proceeding before any court, governmental
agency or body, domestic or foreign, now pending or, to the knowledge of the Company, threatened against the Company or its subsidiaries
wherein an unfavorable decision, ruling or finding would reasonably be expected to, individually or in the aggregate, (i) materially
adversely affect the validity or enforceability of, or the authority or ability of the Company to perform its obligations under,
the Transaction Agreements or (ii) have a Material Adverse Effect. The Company is not a party to or subject to the provisions
of any injunction, judgment, decree or order of any court, regulatory body, administrative agency or other governmental agency
or body that might have, individually or in the aggregate, a Material Adverse Effect.

 

(j)         
No Violations. Neither the Company nor any of its subsidiaries is in violation of its respective certificate of incorporation,
bylaws or other organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation,
ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration
panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the aggregate, would
be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries is in default (and there
exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the
performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed of trust or any
other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the Company or any
of its subsidiaries is bound or by which the properties of the Company are bound, which would be reasonably likely to have a Material
Adverse Effect. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation
by the SEC

 

    	 	4	 

     

    

 

involving the Company or any current or former
director or officer of the Company and the Company is not an “ineligible issuer” pursuant to Rules 164, 405 and 433
under the Securities Act. The Company has not received any comment letter from the SEC relating to any SEC Documents which has
not been resolved. The SEC has not issued any stop order or other order suspending the effectiveness of any registration statement
filed by the Company under the Exchange Act or the Securities Act.

 

(k)         
Listing Compliance. Except as disclosed in its filings with the SEC, the Company is in compliance with the requirements
of The NASDAQ Stock Market for continued listing of the Common Stock thereon and has no knowledge of any facts or circumstances
that could reasonably lead to delisting of its Common Stock from The NASDAQ Stock Market. The Company has taken no action designed
to, or likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act or the listing of
the Common Stock on The NASDAQ Stock Market, nor has the Company received any notification that the SEC or The NASDAQ Stock Market
is contemplating terminating such registration or listing. The transactions contemplated by the Transaction Agreements will not
contravene the rules and regulations of The NASDAQ Stock Market.

 

(l)          
Financial Statements. The consolidated financial statements of the Company and its subsidiaries and the related notes
thereto included in the SEC Documents (the “Financial Statements”) comply in all material respects with applicable
accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing and present
fairly, in all material respects, the financial position of the Company and its subsidiaries as of the dates indicated and the
results of its operations and cash flows for the periods therein specified subject, in the case of unaudited statements, to normal
year-end audit adjustments. Except as set forth in such Financial Statements (or the notes thereto), such Financial Statements
(including the related notes) have been prepared in accordance with U.S. generally accepted accounting principles applied on a
consistent basis throughout the periods therein specified (“GAAP”). Except as set forth in the Financial Statements,
neither the Company nor its subsidiaries has any material liabilities other than liabilities and obligations that have arisen in
the ordinary course of business and which would not be required to be reflected in financial statements prepared in accordance
with GAAP.

 

(m)        Disclosure. The Company understands and confirms that the Purchasers will rely on the foregoing representations in
effecting transactions in the Notes. All disclosure furnished by or on behalf of the Company to the Purchasers in connection with
this Agreement regarding the Company, its business and the transactions contemplated hereby is true and correct in all material
respects and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to
make the statements made therein, in light of the circumstances under which they were made, not misleading. The Company acknowledges
and agrees that the Purchasers have not made and do not make any representations or warranties with respect to the transactions
contemplated hereby other than those set forth in Section 5 hereto.

 

5.     
Investment Representations. In connection with the receipt of the Notes, each Purchaser represents
and warrants to the Company the following:

 

    	 	5	 

     

    

 

(a)        
Organization. Purchaser is duly organized, validly existing, and in good standing under the laws of the jurisdiction
of its organization.

 

(b)        
Power. Purchaser has all requisite power to execute and deliver this Agreement and to carry out and perform its obligations
under the terms of this Agreement.

 

(c)        
Authorization. The execution, delivery, and performance of this Agreement by Purchaser has been duly authorized by
all requisite action, and this Agreement constitutes the legal, valid, and binding obligation of Purchaser enforceable in accordance
with its terms (subject to the Enforceability Exceptions).

 

(d)        
Consents and Approvals. Purchaser need not give any notice to, make any filing with, or obtain any authorization,
consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Agreement.

 

(e)        
Non-Contravention. The execution, delivery and, subject to satisfaction by the Company of the conditions to Closing
set forth in Sections 7 and 8 hereof on or prior to the issuance of the Notes, or performance, by Purchaser of this Agreement do
not and will not contravene or constitute a default under, or violation of, or be subject to penalties under, (i) any agreement
(or require the consent of any party under any such agreement that has not been made or obtained) to which Purchaser is a party,
or (ii) any judgment, injunction, order, decree or other instrument binding upon Purchaser, except where such contravention, default,
violation or failure to obtain a consent, individually or in the aggregate, would not reasonably be expected to impair Purchaser’s
ability to perform fully any obligation which Purchaser has or will have under this Agreement.

 

(f)         
Investor Qualification. Purchaser understands the definition of the term “accredited investor” within
the meaning of Regulation D, Rule 501(a), promulgated by the SEC under the Securities Act, and qualifies as an accredited
investor.

 

(g)        
Information; Purchase for Investment Only. Purchaser is aware of the Company’s business affairs and financial
condition and has acquired sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Notes. Purchaser is acquiring the Notes for investment for its own account only and not with a view to, or for resale in connection
with, any “distribution” thereof within the meaning of the Securities Act or under any applicable provision of state
law. Purchaser does not have any present intention to transfer the Notes to any other person or entity in such a “distribution.”

 

(h)        
No Registration. Purchaser understands that the Notes have not been registered under the Securities Act by reason
of a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Purchaser’s
investment intent as expressed herein.

 

(i)          
Restricted Securities. Purchaser understands that the Notes are “restricted securities” under applicable
U.S. federal and state securities laws and that, pursuant to these laws, Purchaser must hold the Notes indefinitely unless they
are registered with the SEC and qualified by state authorities, or an exemption from such registration and qualification requirements
is

 

    	 	6	 

     

    

 

available. Purchaser acknowledges that the Company
has no obligation to register or qualify the Notes for resale.

 

(j)         
Risk of Investment. Purchaser realizes that the purchase of the Notes will be a highly speculative investment and
Purchaser may suffer a complete loss of its investment. Purchaser understands all of the risks related to the purchase of the Notes.
By reason of its business and financial experience, Purchaser has the ability to protect its own interests in connection with the
purchase of the Notes.

 

(k)        
Advisors. Purchaser has reviewed with its own tax advisors the federal, state, and local tax consequences of this
investment and the transactions contemplated by this Agreement. Purchaser acknowledges that it has had the opportunity to review
this Agreement and the transactions contemplated hereby with Purchaser’s own legal counsel.

 

(l)          
Finder. Purchaser is not obligated and will not be obligated to pay any broker commission, finders’ fee, success
fee, or commission in connection with the transactions contemplated by this Agreement.

 

6.     
Restrictive Legends and Stop-Transfer Orders. The Notes shall bear such legends as the Company deems
to be required for the purpose of compliance with applicable federal or state securities laws or as otherwise required by law.

 

7.     
Conditions to Company’s Obligations at the Closing. The Company’s obligation to complete
the sale and issuance of the Notes, and deliver the Notes to the Purchasers at the Closing shall be subject to the following conditions
to the extent not waived by the Company:

 

(a)        
Receipt of Payment. The Company shall have received payment (or confirmation that an Irrevocable Payment Instruction
has been made with respect to such payment), by wire transfer of immediately available funds or by cancellation of indebtedness
of the Company to each applicable Purchaser, in the full amount of the Purchase Price for the Notes being purchased by such Purchaser
at the Closing.

 

(b)        
Representations and Warranties. The representations and warranties made by the Purchasers in Section 5 hereof
shall be true and correct in all material respects as of, and as if made on, the date of such Closing.

 

(c)        
Subordination Agreement. The Purchasers shall have executed and delivered to the Company the Subordination Agreement
(as defined in Section 9(b)(ii) hereof).

 

8.     
Conditions to Purchaser’s Obligations at the Closing. Each Purchaser’s obligation to accept
delivery of the Notes and to pay for such Purchaser’s respective Notes at the Closing shall be subject to the following conditions
to the extent not waived by such Purchaser:

 

(a)        
Representations and Warranties. The representations and warranties made by the Company in Section 4 hereof shall
be true and correct in all material respects (except for any representations and warranties which are qualified as to materiality,
which shall be true and correct in all respects) as of, and as if made on, the date of this Agreement and as of the date of the
Closing as though such representations and warranties were made on and as of such date.

 

    	 	7	 

     

    

 

(b)       
Certificate. The Purchaser shall have received a certificate dated as of the Closing and signed by the Company’s
Chief Executive Officer and Chief Financial Officer to the effect that the representations and warranties of the Company in Section 4
hereof are true and correct in all material respects (except for any representations and warranties which are qualified as to materiality,
which shall be true and correct in all respects) as of, and as if made on, the date of this Agreement and as of the Closing, and
that the Company has satisfied all of the conditions set forth in this Agreement and required to be satisfied as of the Closing.

 

(c)        
Good Standing. The Company shall be validly existing as a corporation in good standing under the laws of Delaware
as evidenced by a certificate of the Secretary of State of the State of Delaware, a copy of which shall be provided to the Purchaser
at the Closing.

 

(d)        
Board Approval. The terms and conditions of the issuance of the Notes and the Transaction Agreements shall have been
duly approved by the Board of Directors of the Company (including the Audit Committee and at least six directors who are disinterested
with respect to the transactions contemplated hereby).

 

(e)        
Other Approvals. The Company shall have obtained all governmental, regulatory or third party consents and approvals
required in connection with the transactions contemplated hereby, if any, including obtaining the Pre-Closing Consents and any
waivers of any other negative covenants and pro rata or similar preemptive rights that may apply to the issuance of the Notes.

 

(f)        
Foris Ventures Investment. The Company and Foris Ventures, LLC shall have executed a Note Purchase Agreement by and
among the Company and Foris Ventures, LLC dated as of October 21, 2016 in substantially the form of this Agreement, and Foris Ventures,
LLC shall have purchased secured convertible promissory notes in substantially the form of Note attached as Exhibit A hereto in
the principal amount of $6,000,000. In addition, Foris Ventures, LLC shall have provided to the Company its written acknowledgment
and agreement that the Notes shall be pari passu with all notes issued to Foris Ventures, LLC and outstanding as of the date hereof
(including the note referenced in the prior sentence).

 

9.     
Other Agreements

 

(a)        
SEC Filings. Upon execution of this Agreement and the issuances of Notes, the Company will complete any SEC filings
(such as a Current Report on Form 8-K) that are, in the judgment of the Company’s legal counsel, required to be completed.

 

(b)        
Security Interest.

 

(i)        
As security for the prompt, complete and indefeasible payment when due (whether on the payment dates or otherwise) of all
the Company’s obligations under the Notes, including any obligation to pay any amount now owning or later arising under the
Notes (collectively, the “Secured Obligations”), the Company grants to each Purchaser a second priority security interest
in all of the Company’s right, title, and interest in and to the Collateral (as defined in that certain Loan and Security
Agreement dated as of March 29, 2014, as amended on June 12, 2014, March 31, 2015, November 30, 2015 and October 6, 2016 (as amended,
the “LSA”) by and between the Company, and each of its subsidiaries that has delivered a Joinder Agreement (as

 

    	 	8	 

     

    

 

defined in the LSA), the other financial institutions
or entities from time to time parties to the LSA (collectively, referred to as “Lender”) and Stegodon Corporation,
a Delaware corporation, as assignee of Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent
for itself and the Lender (in such capacity, the “Agent”)), as limited by Section 3.2 of the LSA.

 

(ii)      
The Company hereby agrees to enter into any additional Security Documents (as defined below) with the Purchasers as may
be reasonably required by the Purchasers in connection with the grant of the security interest contemplated by Section 9(b)(i)
hereof, provided, however, that such security interest shall be subject to the Subordination Agreement dated as of October 27,
2016, by and among the Purchasers, the Company and the Agent (the “Subordination Agreement”). As used herein,
“Security Documents” means each security agreement, all other mortgages, deeds of trust, security agreements,
pledge agreements, assignments, control agreements, financing statements and other documents as shall from time to time secure
or relate to the Secured Obligations or any part thereof, in each case, executed by the Company or any subsidiary of the Company.

 

10.     
Miscellaneous.

 

(a)        
Governing Law. This Agreement and all acts and transactions pursuant hereto and the rights and obligations of the
parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of California, without giving
effect to principles of conflicts of law.

 

(b)        
Assignment; Successors and Assigns. This Agreement may not be assigned by the Purchaser without the prior written
consent of the Company; provided, that this Agreement may be assigned by a Purchaser to the valid transferee of any security
purchased hereunder if such security remains a “restricted security” under the Securities Act. This Agreement and all
provisions thereof shall be binding upon, inure to the benefit of, and are enforceable by the parties hereto and their respective
successors and permitted assigns.

 

(c)  
      Notices. All notices, requests, and other communications hereunder shall be in
writing and will be deemed to have been duly given and received (i) when personally delivered, (ii) when sent by
facsimile upon confirmation of receipt, (iii) one business day after the day on which the same has been delivered
prepaid to a nationally recognized courier service, or (iv) five business days after the deposit in the United States
mail, registered or certified, return receipt requested, postage prepaid, in each case addressed, as to the Company, to
Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number:           , with a copy
to Fenwick & West LLP, 801 California Street, Mountain View, CA 94041, Attn:                , facsimile number:              , and as to each
Purchaser at the address set forth opposite such Purchaser’s name on the Schedule of Purchasers on Schedule I.
Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices
to that party by giving notice specifying such change to the other parties hereto. The Purchasers and the Company may each
agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to
procedures reasonably approved by it; provided that approval of such procedures may be limited to particular notices or
communications. 

 

    	 	9	 

     

    

 

(d)       
Severability. In the event that any provision of this Agreement or the application of any provision hereof is declared
to be illegal, invalid, or otherwise unenforceable by a court of competent jurisdiction, the remainder of this Agreement shall
not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision
held invalid shall substantially impair the benefits of the remaining portions of this Agreement.

 

(e)        
Headings. The headings in this Agreement are for convenience of reference only and shall not constitute a part of
this Agreement, nor shall they affect its meaning, construction, or effect.

 

(f)         
Entire Agreement. This Agreement embodies the entire understanding and agreement between the parties hereto with
respect to the subject matter hereof and supersedes all prior agreements and understandings relating to the subject matter hereof.

 

(g)        
Expenses. Each party will bear its own costs and expenses in connection with this Agreement.

 

(h)        
Further Assurances. The parties agree to execute and deliver all such further documents, agreements and instruments
and take such other and further action as may be necessary or appropriate to carry out the purposes and intent of this Agreement.

 

(i)         
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall constitute an original,
but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts
have been signed by each party hereto and delivered to the other party. Facsimile signatures shall be deemed originals for all
purposes hereunder.

 

(j)         
Amendments and Waivers. This Agreement may not be amended, supplemented or otherwise modified except in a written
instrument executed by the Company and the holders of a majority of the aggregate principal amount of the then outstanding Notes.
No waiver by any of the parties of any default, misrepresentation, or breach of warranty or covenant hereunder, whether intentional
or not, shall be deemed to extend to any prior or subsequent default, misrepresentation, or breach of warranty or covenant hereunder
or affect in any way any rights arising by virtue of any prior or subsequent such occurrence. No waiver by any of the parties of
any of the provisions hereof shall be effective unless explicitly set forth in writing and executed by the party sought to be charged
with such waiver. No action taking pursuant to this Agreement, including any investigation by or on behalf of any party, shall
be deemed to constitute a waiver by the party taking such action of compliance with any representation, warranty, covenant or agreement
contained herein. No failure on the part of any party to exercise, and no delay in exercising, any right, power or remedy hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of such right, power or remedy by such party preclude
any other or further exercise thereof or the exercise of any other right, power or remedy.

 

[Signature Pages Follow]

 

 

 

 

 

    	 	10	 

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	the company:	 
	 	 	 	 
	 	AMYRIS, inc.	 
	 	 	 	 
	 	By:	/s/ Raffi Asadorian 	 
	 	 	(Signature)	 
	 	 	 	 
	 	Name: Raffi Asadorian	 
	 	 	 	 
	 	Title: Chief Financial Officer
	 	 	 	 
	 	Address: 	 
	 	5885 Hollis Street, Suite 100
	 	Emeryville, CA 94608
	 	Attention: General Counsel
	 	Facsimile: 
	 	Email:

 

 

 

 

 

 

    	 	Note Purchase Agreement Signature Page	 

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	PURCHASER:	 
	 	 	 	 
	 	GINKGO BIOWORKS, INC.
	 	 	 	 
	 	By:	/s/ Jason Kelly 	 
	 	 	(Signature)	 
	 	 	 	 
	 	Name:	Jason Kelly 	 
	 	 	 	 
	 	Title:	CEO 	 

 

 

 

 

 

 

 

    	 	Note Purchase Agreement Signature Page	 

     

    

 

Schedule
I

 

Schedule of Purchasers

 

Closing: October 27, 2016

 

	Name of Purchaser	Notes Principal Amount	Note Purchase Price	Address 
	Ginkgo Bioworks, Inc.	$8,500,000	$8,500,000	Ginkgo Bioworks, Inc.
	 	 	 	27 Drydock Ave., Floor B
	 	 	 	Boston, MA 02127
	 	 	 	Attention: Jason Kelly
	TOTAL	$8,500,000	$8,500,000	 

 

 

 

 

 

 

 

 

 

     

     

    

 

exhibit
a

 

form
of note

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