Document:

EX-10.3

 Exhibit 10.3 

STOCK OPTION AGREEMENT 

PURSUANT TO THE 

MARKETAXESS HOLDINGS INC. 

2012 INCENTIVE PLAN 
 STOCK
OPTION AGREEMENT (“Agreement”), dated as of November 8, 2018 by and between MarketAxess Holdings Inc. (the “Company”) and Richard M. McVey (the “Executive”). 

Preliminary Statement 

The Board of Directors of the Company (the “Board”) or a committee appointed by the Board (the “Committee”) to administer
the MarketAxess Holdings Inc. 2012 Incentive Plan, as amended (the “Plan”), has authorized this grant of an incentive stock option (the “Option”) on November 8, 2018 (the “Grant Date”) to purchase the number of
shares of the Company’s common stock, par value $.003 per share (the “Common Stock”) set forth below to the Executive, as an Eligible Employee of the Company or an Affiliate (collectively, the Company and all Subsidiaries and Parents
of the Company shall be referred to as the “Employer”). Unless otherwise indicated, any capitalized term used but not defined herein shall have the meaning ascribed to such term in the Plan. A copy of the Plan has been delivered to the
Executive. By signing and returning this Agreement, the Executive acknowledges having received and read a copy of the Plan and agrees to comply with it, this Agreement and all applicable laws and regulations. 

Accordingly, the parties hereto agree as follows: 

1. Tax Matters. The Option granted hereby is intended to qualify as an “incentive stock option” under Section 422
of the Internal Revenue Code of 1986, as amended (the “Code”). Notwithstanding the foregoing, the Option will not qualify as an “incentive stock option,” among other events, (i) if the Executive disposes of the Common Stock
acquired pursuant to the Option at any time during the two (2) year period following the date of this Agreement or the one (1) year period following the date on which the Option is exercised; (ii) except in the event of the
Executive’s death or disability, as defined in Section 22(e)(3) of the Code, if the Executive is not employed by the Company, any Subsidiary or any Parent at all times during the period beginning on the date of this Agreement and ending on
the day three (3) months before the date of exercise of the Option; or (iii) to the extent the aggregate fair market value (determined as of the time the Option is granted) of the Common Stock subject to “incentive stock options”
which become exercisable for the first time in any calendar year exceeds $100,000. To the extent that the Option does not qualify as an “incentive stock option,” it shall not affect the validity of the Option and the portion of the Option
that does not qualify as an “incentive stock option” shall constitute a separate non-qualified stock option. 

 2. Grant of Option. Subject in all respects to the Plan and the terms and
conditions set forth herein and therein, the Executive is hereby granted an Option to purchase from the Company 79,411 shares of Common Stock, at a price per share equal to 135% of the Fair Market Value of the Company’s stock on the grant date,
or $278.40 (the “Option Price”), provided that, notwithstanding anything in this Agreement, the Plan, or any agreement between the Executive and the Company to the contrary, in the event that on or prior to January 1, 2020, (i)
a Change in Control occurs, and (ii) the Executive incurs a Termination without Cause or for Good Reason (the “Early Trigger Event”), this Option shall be an Option to purchase15,882 shares of Common Stock, and the portion of
this Option with respect to 63,529 shares of Common Stock shall be deemed forfeited and canceled as of the date of such Early Trigger Event. 

3. Exercise. (a) Except as set forth in subsections (b) through (e) below, the Option shall fully vest and become
exercisable on November 8, 2023. 
 To the extent that the Option has become vested and exercisable with respect to a number of
shares of Common Stock as provided above, the Option may thereafter be exercised by the Executive, in whole or in part, at any time or from time to time prior to the expiration of the Option as provided herein and in accordance with
Section 6.4(d) of the Plan, including, without limitation, by the filing of any written form of exercise notice as may be required by the Committee and payment in full of the Option Price multiplied by the number of shares of Common Stock
underlying the portion of the Option exercised. Payment of the Option Price may be made by any method provided under Section 6.4(d) of the Plan, including, without limitation, (i) solely to the extent permitted by applicable law, if the
Common Stock is traded on a national securities exchange or quoted on a national quotation system sponsored by the Financial Industry Regulatory Authority, through a procedure whereby the Executive delivers irrevocable instructions to a broker
reasonably acceptable to the Committee to deliver promptly to the Company an amount equal to the Option Price or (ii) the relinquishment of a portion of the Option based on the Fair Market Value of the Common Stock on the payment date. Upon
expiration of the Option, the Option shall be canceled and no longer exercisable. 
 There shall be no proportionate or partial vesting in
the periods prior to each vesting date and all vesting shall occur only on the appropriate vesting date. The Committee may, in its sole discretion, provide for accelerated vesting of the Option at any time. 

(b) Upon the death or Disability of the Executive, fifty percent (50%) of the then unvested portion the Option shall become fully vested and
exercisable on the date of the Executive’s death or Disability. 
 (c) Upon the Executive’s Termination (i) by the Company
without Cause, or (ii) by the Executive for Good Reason, one hundred percent (100%) of the then unvested portion the Option shall become fully vested and exercisable on the date of such Termination. 

  
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 (d) In the event that the Executive engages in Detrimental Activity (as defined in Exhibit A
hereto) prior to any exercise of the Option, the Option shall thereupon terminate and expire. As a condition of the exercise of the Option, the Executive shall certify (or shall be deemed to have certified) at the time of exercise in a manner
acceptable to the Company that the Executive is in compliance with the terms and conditions of the Plan and that the Executive has not engaged in, and does not intend to engage in, any Detrimental Activity. In the event the Executive engages in
Detrimental Activity during the one (1) year period commencing on the date any portion of the Option is exercised or becomes vested, the Company shall be entitled to recover from the Executive at any time within one (1) year after such
exercise or vesting, and the Executive shall pay over to the Company, an amount equal to any gain realized as a result of the exercise (whether at the time of exercise or thereafter). The foregoing provisions of this Section 3(d) shall cease to
apply upon a Change in Control. 
 (e) Notwithstanding any other provision to the contrary in this Agreement, any unvested portion of the
Option shall, upon the Executive’s Termination, be non-exercisable and shall be canceled. 
 4.
Option Term. The term of each Option shall expire on May 8, 2024, subject to earlier termination in the event of the Executive’s Termination as specified in Section 5 below. 

5. Termination. Subject to the terms of the Plan and this Agreement, the Option, to the extent vested at the time of the
Executive’s Termination, shall remain exercisable as follows: 
 (a) In the event of the Executive’s Termination by reason of death
or Disability, the vested portion of the Option shall remain exercisable until the earlier of (i) two (2) years from the date of such Termination or (ii) the expiration of the stated term of the Option pursuant to Section 4 hereof.

 (b) In the event of the Executive’s involuntary Termination without Cause, or the Executive’s voluntary Termination for Good
Reason, the vested portion of the Option shall remain exercisable until the expiration of the stated term of the Option pursuant to Section 4 hereof. 

(c) In the event of the Executive’s voluntary Termination without Good Reason (other than a voluntary Termination described in
Section 5(d) below), the vested portion of the Option shall remain exercisable until the earlier of (i) ninety (90) days from the date of such Termination or (ii) the expiration of the stated term of the Option pursuant to
Section 4 hereof. 
 (d) In the event of the Executive’s Termination for Cause or in the event of the Executive’s voluntary
Termination without Good Reason within ninety (90) days after an event that would be grounds for a Termination for Cause, the Executive’s entire Option (whether or not vested) shall terminate and expire upon the date of such Termination.

  
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 6. Restriction on Transfer of Option. No part of the Option shall be
Transferred other than by will or by the laws of descent and distribution and during the lifetime of the Executive, may be exercised only by the Executive or the Executive’s guardian or legal representative. In addition, the Option shall not be
assigned, negotiated, pledged or hypothecated in any way (except as provided by law or herein), and the Option shall not be subject to execution, attachment or similar process. Upon any attempt to Transfer the Option or in the event of any levy upon
the Option by reason of any execution, attachment or similar process contrary to the provisions hereof, such transfer shall be void and of no effect and the Company shall have the right to disregard the same on its books and records and to issue
“stop transfer” instructions to its transfer agent. 
 7. Rights as a Stockholder. The Executive shall have no rights
as a stockholder with respect to any shares covered by the Option unless and until the Executive has become the holder of record of the shares, and no adjustments shall be made for dividends in cash or other property, distributions or other rights
in respect of any such shares, except as otherwise specifically provided for in the Plan. 
 8. Provisions of Plan Control.
This Agreement is subject to all the terms, conditions and provisions of the Plan, including, without limitation, the amendment provisions thereof, and to such rules, regulations and interpretations relating to the Plan as may be adopted by the
Committee and as may be in effect from time to time. The Plan is incorporated herein by reference. If and to the extent that this Agreement conflicts or is inconsistent with the terms, conditions and provisions of the Plan, the Plan shall control,
and this Agreement shall be deemed to be modified accordingly. This Agreement contains the entire understanding of the parties with respect to the subject matter hereof (other than any exercise notice or other documents expressly contemplated herein
or in the Plan) and supersedes any prior agreements between the Company and the Executive with respect to the subject matter hereof. 
 9.
Notices. Any notice or communication given hereunder shall be in writing and shall be deemed to have been duly given: (i) when delivered in person; (ii) two (2) days after being sent by United States mail; or (iii) on
the first business day following the date of deposit if delivered by a nationally recognized overnight delivery service, to the appropriate party at the address set forth below (or such other address as the party shall from time to time specify):

 If to the Company, to: 

MarketAxess Holdings Inc. 
 299
Park Avenue, 10th Floor 
 New York, New York, 10171 

Attention: Compensation Committee 

If to the Executive, to the address on file with the Company. 

  
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 10. No Obligation to Continue Employment. This Agreement is not an agreement
of employment. This Agreement does not guarantee that the Employer will employ the Executive for any specific time period, nor does it modify in any respect the Employer’s right to terminate or modify the Executive’s employment or
compensation. 
 [END OF TEXT. SIGNATURE PAGE
FOLLOWS.] 

  
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 IN WITNESS WHEREOF, the parties have executed this Agreement on the date and year first
above written. 
  

			
	MARKETAXESS HOLDINGS INC.
		
	By:	 	 /s/ Antonio L. DeLise

		 	Name: Antonio L. DeLise
		 	Title:   Chief Financial Officer

  

	
	 EXECUTIVE:
  

/s/ Richard M. McVey

	  
 Richard M. McVey

  
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 EXHIBIT A 

DEFINITION OF DETRIMENTAL ACTIVITY 

For purposes of this Agreement, “Detrimental Activity” shall mean: (a) the disclosure to anyone outside the Company or
its affiliates, or the use in any manner other than in the furtherance of the Company’s or its affiliate’s business, without written authorization from the Company, of any confidential information or proprietary information, relating to
the business of the Company or its affiliates that is acquired by an Executive prior to the Executive’s Termination; (b) activity while employed or performing services that results, or if known could result, in the Executive’s
Termination that is classified by the Company as a Termination for Cause; (c) engaging in Solicitation (as defined below) without, in all cases, written authorization from the Company; (d) the making of disparaging comments or statements
by the Executive, or the inducement of others by the Executive to make any disparaging comments or statements, to the press, the Company’s or its affiliates’ employees, consultants or any individual or entity with whom the Company or its
affiliates has a business relationship which could reasonably be expected to adversely affect in any manner: (i) the conduct of the business of the Company or its affiliates (including, without limitation, any products or business plans or
prospects); or (ii) the business reputation of the Company or its affiliates, or any of their products, or their past or present officers, directors or employees; (e) without written authorization from the Company, engaging in Competition
(as defined below). For purposes of sub-sections (a), (c), and (e) above, the Board shall have authority to provide the Executive with written authorization to engage in the activities contemplated
thereby and no other person shall have authority to provide the Executive with such authorization. 
 “Competition” means
the Executive’s participation, directly or indirectly, as an individual proprietor, partner, stockholder, officer, employee, director, joint venturer, investor, lender, consultant or in any capacity whatsoever (within the United States or in
any foreign country where the Company or its affiliates does business) in a business (whether a division, unit, subsidiary or affiliate), other than the Company and its affiliates: (i) that is engaged in the design, development, operation or
promotion of a multi-dealer electronic platform or electronic commerce network (ECN) for fixed income securities (or other fixed income instruments) information research, distribution, trading and/or other transactions; (ii) whose principal
business is electronic distribution, research and/or trading of fixed income securities (or other fixed income instruments); or (iii) that is not included in subsections (i) or (ii) and as to which the Company or its affiliates have taken
demonstrable steps at the time of termination of the Executive’s employment. Competition does not include: (i) the Executive’s ownership of not more than 1% of the total outstanding stock of a publicly held company; or (ii) the
Executive’s performance of services for any enterprise to the extent such services are not performed, directly or indirectly, for a business in the aforesaid Competition (including, without limitation, his performance of services for any entity
which has a division or business unit engaging in competition with the Company’s or its affiliates’ business, if such performance does not in any capacity, 

  
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directly or indirectly, involve work with or assistance to such division or business unit). The meaning of “as to which the Company has taken demonstrable steps” shall be determined by
the Board in good faith based on written memoranda or similar writings or communications and such determination shall be conclusive and binding for all purposes hereunder. 

“Solicitation” means (i) recruiting, soliciting or inducing any nonclerical employee or consultant of the Company or its
affiliates to terminate his or her employment with, or otherwise cease or reduce his or her relationship with, the Company or such affiliate; (ii) hiring or assisting another person or entity to hire any nonclerical employee or consultant of
the Company or its affiliates or any person who, to the Executive’s knowledge, within six months before was such a person; or (iii) soliciting or inducing any person or entity to terminate, or otherwise to cease, reduce, or diminish in any
way its relationship with or prospective relationship with the Company or its affiliates. You may however, if requested by any entity with which you are not affiliated, serve as a reference for any person who at the time of the request is not an
employee of, or consultant to, the Company or its affiliates. 

  
 8EX-10.4

 Exhibit 10.4 

PERFORMANCE SHARE AWARD AGREEMENT 

PURSUANT TO THE 

MARKETAXESS HOLDINGS INC. 

2012 INCENTIVE PLAN 

THIS PERFORMANCE SHARE AWARD AGREEMENT (this “Agreement”), made effective as of November 8, 2018, by and between
MarketAxess Holdings Inc. (the “Company”) and Richard M. McVey (the “Participant”). 
 WHEREAS, the
Board of Directors of the Company (the “Board”) adopted, and the stockholders of the Company approved, the MarketAxess Holdings Inc. 2012 Incentive Plan (as amended April 17, 2018, the “Plan”); 

WHEREAS, the Company, through the Committee under the Plan, wishes to grant to the Participant a Performance Share Award under the Plan
that, upon the achievement of the performance metric set forth on Appendix A attached hereto and subject to the Participant’s continuing service with the Company or an Affiliate, may provide for the issuance of shares of the
Company’s common stock, par value $.003 per share (“Common Stock”) in accordance with the terms of this Agreement; 

WHEREAS, the performance metric set forth on Appendix A attached hereto is intended to constitute a “performance goal”
as set forth under the Plan; and 
 WHEREAS, such shares of Common Stock, when issued to the Participant, shall be subject to the
terms of this Agreement (including without limitation, the restrictions set forth in Sections 4 and 5 herein). 
 NOW, THEREFORE, the
Company and the Participant agree as follows: 
 1. Grant of Performance Share Award. Subject to the restrictions, terms
and conditions of the Plan and this Agreement, the Company hereby awards and grants to the Participant 17,942 Performance Shares entitling the Participant to receive, for each Performance Share earned in accordance with
Section 2 below, one share of Common Stock, subject to the provisions of Appendix A attached hereto (the “Performance Share Award”) , provided that, notwithstanding anything in this Agreement,
the Plan, or any agreement between the Participant and the Company to the contrary, in the event that on or prior to January 1, 2020, (i) a Change in Control occurs, and (ii) the Participant incurs a Termination of Employment for without
Cause or for Good Reason (the “Early Trigger Event”), this Performance Share Award shall be an award with respect to 3,588 Performance Shares, and the portion of this Performance Share Award with respect to 14,354 Performance Shares
shall be deemed forfeited and canceled as of the date of such Early Trigger Event. 
 2. Payment. Within sixty (60) days
following the date of the achievement (the “Achievement Date”) of the performance metric set forth on Appendix A attached hereto during the performance period beginning on November 8, 2018 and ending on November 8,
2023 (the “Performance Period”), the Committee shall certify that such level of achievement of the performance metric has been achieved (the date of any such certification, a “Settlement Date”). Subject to the
Participant’s not incurring a Termination of Employment prior to the Settlement Date (except as otherwise specifically set forth in this Agreement), on such Settlement Date the Company shall 

 
award to the Participant the number of Awarded Shares (as defined in Appendix A) reflecting the level of attainment of the performance metric on the applicable Achievement Date as set
forth on Appendix A attached hereto. Pursuant to Sections 4 and 5 hereof, any Awarded Shares granted hereunder shall be subject to certain restrictions, which restrictions relate to the passage of time as an employee of, or consultant to, the
Company or its Affiliates, as described in Section 4.1 hereof. While such restrictions are in effect, the Awarded Shares granted subject to such restrictions shall be referred to herein as “Restricted Stock.” The Performance
Shares and, if any, the number of Awarded Shares and the number of shares of Restricted Stock are subject to adjustment under Section 4.2(b) of the Plan. The provisions in Section 9.1 of the Plan regarding Detrimental Activity shall apply
to the Performance Share Award and for such purpose the applicable Settlement Date shall be considered a vesting date with respect to the Awarded Shares awarded to the Participant on such Settlement Date. 

3. Termination of Employment/ Change in Control Prior to Settlement Date.  

3.1. Termination of Employment.  
  

	 	(a)	 In the event of the Participant’s Termination of Employment by reason of death or Disability that in
either case occurs within twelve (12) months prior to an Achievement Date, then on the applicable Settlement Date the Participant (or the Participant’s estate in the event of the Participant’s death) shall receive the Awarded Shares
that the Participant would have received if the Participant had been employed by the Company on such Settlement Date, based on the level of achievement of the performance metric on the applicable Achievement Date, and all Restricted Stock
corresponding to such Awarded Shares shall become immediately vested. 

  

	 	(b)	 In the event of the Participant’s Termination of Employment by the Company without Cause or by the
Participant for Good Reason that in either case occurs within twelve (12) months prior to an Achievement Date, then on the applicable Settlement Date the Participant shall receive the Awarded Shares that the Participant would have received if
the Participant had been employed by the Company on such Settlement Date, based on the level of achievement of the performance metric on the applicable Achievement Date, 50% of the total number of shares of Restricted Stock corresponding to such
Awarded Shares shall vest immediately and any remaining unvested shares of Restricted Stock corresponding to such Awarded Shares shall be forfeited. 

3.2. Change in Control. In the event of a Change in Control during the Performance Period, if the highest price per share
of Common Stock paid in the transaction related to such Change in Control equals a price per share of Common Stock under a Performance Level, as defined in and set forth on Appendix A, that was not achieved prior to such Change in Control,
then on the Change in Control the Participant shall receive the Awarded Shares payable with respect to such Performance Level and all Restricted Stock corresponding to such Awarded Shares shall become immediately vested. In addition, the Committee,
in its sole discretion, may treat any then unearned Performance Shares under this Performance Share Award in accordance with any one or more of the following methods as determined by the Committee: 

  
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	 	(a)	 The Committee may determine that one or more of the levels of achievement of the performance metric set forth
on Appendix A not achieved upon or prior to the Change in Control would likely have been achieved during the Performance Period and treat all or a portion of the Performance Share Award in accordance with any one of the following methods, as
determined by the Committee: 

  

	 	(i)	 The Committee may determine that a level of achievement of the performance metric set forth on Appendix
A not achieved upon or prior to the Change in Control is deemed achieved on the date of the Change in Control, the Participant shall be granted the applicable number of Awarded Shares set forth on Appendix A, subject to the conditions of
Section 4; provided, that all unvested shares of Restricted Stock corresponding to such Awarded Shares shall become immediately vested if (x) such Change in Control occurs within three months following a Termination of Employment by the
Participant for Good Reason or (y) the Participant incurs a Termination of Employment by the Company without Cause within 24 months following such Change in Control; 

 

	 	(ii)	 Immediately prior to the Change in Control, the Committee may determine that the Performance Share Award will
not be continued, assumed or have new rights substituted therefor in accordance with Section 12.1(a) of the Plan and the Participant will be granted the applicable number of Awarded Shares set forth on Appendix A with respect to the
levels of achievement of the performance metric set forth on Appendix A not achieved upon or prior to the Change in Control that the Committee has determined would likely have been achieved during the Performance Period, and all shares of
Restricted Stock corresponding to such Awarded Shares shall vest upon the Change in Control; or 

  

	 	(iii)	 Immediately prior to the Change in Control, the Committee may determine that the Performance Share Award will
be continued, assumed or have new rights substituted therefor in accordance with Section 12.1(a) of the Plan. 

  

	 	(b)	 The Committee may determine that the level of achievement of the performance metric set forth on Appendix
A not achieved upon or prior to the Change in Control would likely not have been achieved during the Performance Period and treat all or a portion of the Performance Share Award in accordance with any one of the following methods as determined
by the Committee: 

  
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	 	(i)	 Immediately prior to the Change in Control, the Committee may determine the applicable number of Awarded Shares
set forth on Appendix A with respect to a level of achievement of the performance metric set forth on Appendix A not achieved upon or prior to the Change in Control that the Committee has determined would likely not have been achieved
during the Performance Period will be canceled in their entirety; or 

  

	 	(ii)	 Immediately prior to the Change in Control, the Committee may determine that the Performance Share Award will
be continued, assumed or have new rights substituted therefor in accordance with Section 12.1(a) of the Plan. 

  

	 	(c)	 The Committee may elect not to make a determination of the likely achievement of the levels of achievement of
the performance metrics set forth on Appendix A and treat the Performance Share Award in accordance with Section 12.1 of the Plan. 

  

	 	(d)	 Notwithstanding any other provision herein, the Committee may otherwise determine the treatment of the
Performance Share Award, which shall not be inconsistent with any of the terms of the Plan. 

 4. Restricted
Stock. 
 4.1. Vesting. Any Restricted Stock issued hereunder shall become vested and cease to be
Restricted Stock (but shall remain subject to the other terms of this Agreement and the Plan) as follows if the Participant has been continuously employed by or otherwise provides services to the Company or an Affiliate from the applicable
Settlement Date until the applicable vesting date: 
  

					
	 Vesting Date
	  	Percentage Vested	 
	 November 8, 2023
	  	 	100	% 

 Except as otherwise provided herein, there shall be no proportionate or partial vesting in the periods prior to the applicable
vesting dates and all vesting shall occur only on the appropriate vesting date. When any shares of Restricted Stock become vested, the Company shall promptly deliver to the Participant any related RS Property (as defined below), subject to
applicable withholding. 
 4.2. Detrimental Activity. The provisions in Section 8.1 of the Plan regarding Detrimental
Activity shall apply to the Restricted Stock. 
 4.3. Termination of Employment/ Change in Control.  

 

	 	(a)	 Termination of Employment.  

 

	 	(i)	 In the event of the Participant’s Termination of Employment by reason of death or Disability, in either
case on or after a Settlement Date, then all then issued and unvested Restricted Stock shall become immediately vested. 

  
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	 	(ii)	 In the event of the Participant’s Termination of Employment by the Company without Cause or by the
Participant for Good Reason, 50% of the total number of then issued and unvested shares of Restricted Stock granted pursuant to this Agreement shall become immediately vested. Any remaining unvested shares of Restricted Stock that could vest
pursuant to Section 4.3(b)(i)(x) below shall remain outstanding for a period of three (3) months following the date of such termination; provided that such shares of Restricted Stock shall only vest in accordance with
Section 4.3(b)(i)(x) below. 

  

	 	(b)	 Change in Control. 

 

	 	(i)	 If there is a Change in Control and (x) such Change in Control occurs within three months following a
Termination of Employment by the Participant for Good Reason or (y) the Participant incurs a Termination of Employment by the Company without Cause within 24 months following such Change in Control, all then issued and unvested Restricted Stock
shall become immediately vested. 

  

	 	(ii)	 If there is a Change in Control and immediately prior to the Change in Control it is determined that the Award
will not be continued, assumed or have new rights substituted therefor in accordance with Section 12.1(a) of the Plan, then immediately prior to the Change in Control, all then issued and unvested Restricted Stock shall become immediately
vested. 

 4.4. Rights as a Holder of Restricted Stock. From and after any Settlement Date, the
Participant shall have, with respect to the shares of Restricted Stock issued on such Settlement Date, the right to vote such shares of Common Stock, and to exercise all other rights, powers and privileges of a holder of Common Stock with respect to
the Restricted Stock, with the exceptions that (i) no dividends or dividend equivalents shall be due Participant on any Restricted Stock, (ii) the Participant shall not be entitled to delivery of the stock certificate or certificates
representing the Restricted Stock until such shares are no longer Restricted Stock; (iii) the Company (or its designated agent) will retain custody of the stock certificate or certificates representing the Restricted Stock and any other
property (“RS Property”) issued in respect of the Restricted Stock; (iv) no RS Property will bear interest or be segregated in separate accounts; (iv) the Participant shall not, directly or indirectly, Transfer the
Restricted Stock in any manner whatsoever. Prior to the Settlement Date, the Participant shall have no rights as a stockholder with respect to the applicable shares of Common Stock covered by any Restricted Stock to be granted for the applicable
Achievement Date unless and until the Participant has become the holder of record of such Common Stock, and no adjustments shall be made for property, distributions or other rights in respect of any such shares, except as otherwise specifically
provided for in the Plan (including, without limitation, Section 4.2(b) of the Plan). 
 4.5. Taxes;
Section 83(b) Election. The Participant acknowledges, subject to the last sentence of this Section 4.5, that (i) no later than the date on which any Restricted Stock shall have become vested,
the Participant shall pay to the Company, or make arrangements satisfactory to the Company regarding payment of, any Federal, state or local taxes of any kind required by law to be withheld with respect to any Restricted Stock which shall have
become so vested, including by electing to 

  
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reduce the number of shares of Common Stock otherwise deliverable to the Participant or by delivering shares of Common Stock already owned; (ii) the Company shall, to the extent permitted by
law, have the right to deduct from any payment of any kind otherwise due to the Participant any Federal, state or local taxes of any kind required by law to be withheld with respect to any Restricted Stock which shall have become so vested,
including that the Company may, but shall not be required to, sell a number of shares of Common Stock sufficient to cover applicable withholding taxes; and (iii) in the event that the Participant does not satisfy (i) above on a timely
basis, the Company may to the extent permitted by law, but shall not be required to, pay such required withholding and treat such amount as a demand loan to the Participant at the maximum rate permitted by law, with such loan, at the Company’s
sole discretion and provided the Company so notifies the Participant within thirty (30) days of the making of the loan, secured by the Common Stock and any failure by the Participant to pay the loan upon demand shall entitle the Company to all
of the rights at law of a creditor secured by the Common Stock. The Company may hold as security any certificates representing any Common Stock and, upon demand of the Company, the Participant shall deliver to the Company any certificates in his or
her possession representing the Common Stock together with a stock power duly endorsed in blank. The Participant also acknowledges that it is his or her sole responsibility, and not the Company’s, to file timely and properly any election under
Section 83(b) of the Code, and any corresponding provisions of state tax laws, if the Participant wishes to utilize such election. 

4.6. Legend. In the event that a certificate evidencing Restricted Stock is issued, the certificate representing the
Common Stock shall have endorsed thereon the following legends: 
  

	 	(a)	 “THE ANTICIPATION, ALIENATION, ATTACHMENT, SALE, TRANSFER, ASSIGNMENT, PLEDGE, ENCUMBRANCE OR CHARGE OF
THE SHARES OF STOCK REPRESENTED HEREBY ARE SUBJECT TO THE TERMS AND CONDITIONS (INCLUDING FORFEITURE) OF THE MARKETAXESS HOLDINGS INC. (THE “COMPANY”) 2018 INCENTIVE PLAN (THE “PLAN”) AND AN AGREEMENT ENTERED INTO BETWEEN THE
REGISTERED OWNER AND THE COMPANY DATED AS OF NOVEMBER 8, 2018. COPIES OF THE PLAN AND SUCH AGREEMENT ARE ON FILE AT THE PRINCIPAL OFFICE OF THE COMPANY.” 

 

	 	(b)	 Any legend required to be placed thereon by applicable blue sky laws of any state. Notwithstanding the
foregoing, in no event shall the Company be obligated to issue a certificate representing the Restricted Stock prior to vesting as set forth in Section 4.1 hereof. 

5. Restrictions on Transfer. The Participant shall not sell, negotiate, transfer, pledge, hypothecate, assign, encumber or
otherwise dispose of the Performance Share Award or, if any, the shares of Restricted Stock or grant any proxy with respect thereto, except as specifically permitted by the Plan and this Agreement. Any attempted Transfer in violation of this
Agreement and the Plan shall be void and of no effect and the Company shall have the right to disregard the same on its books and records and to issue “stop transfer” instructions to its transfer agent. Notwithstanding the foregoing,
nothing herein or in the Plan shall prohibit the Participant from pledging the Common Stock the Participant is granted hereunder to the Company pursuant to a stock pledge agreement entered into between the parties hereto. 

  
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 6. Issuance Restrictions. The Company is not obligated to issue any
securities if, in the opinion of counsel for the Company, the issuance of such Common Stock shall constitute a violation by the Participant or the Company of any provisions of any law or of any regulations of any governmental authority or any
national securities exchange. 
 7. Securities Representations. The shares of Common Stock will be issued to the
Participant and this Agreement is being made by the Company in reliance upon the following express representations and warranties of the Participant. The Participant acknowledges, represents and warrants that: 

7.1. The Participant has been advised that the Participant may be an “affiliate” within the meaning of Rule 144 under the Securities
Act and in this connection the Company is relying in part on the Participant’s representations set forth in this section; 
 7.2. The
Common Stock must be held indefinitely by the Participant unless (i) an exemption from the registration requirements of the Securities Act is available for the resale of such Common Stock or (ii) the Company files an additional
registration statement (or a “re-offer prospectus”) with regard to the resale of such Common Stock and the Company is under no obligation to continue in effect a Form
S-8 Registration Statement or to otherwise register the resale of the Common Stock (or to file a “re-offer prospectus”); 

7.3. The exemption from registration under Rule 144 will not be available under current law unless (i) a public trading market then exists
for the Common Stock, (ii) adequate information concerning the Company is then available to the public, and (iii) other terms and conditions of Rule 144 or any exemption therefrom are complied with and that any sale of the Common Stock may
be made only in limited amounts in accordance with such terms and conditions. 
 8. Not an Employment Agreement. Neither
the execution of this Agreement nor the issuance of the Performance Share Award or the Common Stock hereunder constitute an agreement by the Company to employ or to continue to employ the Participant during the entire, or any portion of, the term of
this Agreement, including but not limited to any period during which any shares of Common Stock are outstanding. 
 9. Power of
Attorney. The Company, its successors and assigns, is hereby appointed the attorney-in-fact, with full power of substitution, of the Participant for the
purpose of carrying out the provisions of this Agreement and taking any action and executing any instruments which such attorney-in-fact may deem necessary or advisable
to accomplish the purposes hereof, which appointment as attorney-in-fact is irrevocable and coupled with an interest. The Company, as attorney-in-fact for the Participant, may in the name and stead of the Participant, make and execute all conveyances, assignments and transfers of the Restricted Stock, other RS Property, Common Stock and
property provided for herein, and the Participant hereby ratifies and confirms that which the Company, as said attorney-in-fact, shall do by virtue hereof. Nevertheless,
the Participant shall, if so requested by the Company, execute and deliver to the Company all such instruments as may, in the judgment of the Company, be advisable for this purpose. 

  
 -7- 

 10. Miscellaneous. 

10.1. This Agreement shall inure to the benefit of and be binding upon the parties hereto and their respective heirs, personal legal
representatives, successors, trustees, administrators, distributees, devisees and legatees. The Company may assign to, and require, any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise) to all or substantially
all of the business and/or assets of the Company or any affiliate by which the Participant is employed to expressly assume and agree in writing to perform this Agreement. Notwithstanding the foregoing, the Participant may not assign this Agreement
other than with respect to shares of Common Stock Transferred in compliance with the terms hereof. 
 10.2. This award of the Performance
Share Award, and upon the settlement thereof the issuance of Restricted Stock (if any), shall not affect in any way the right or power of the Board or stockholders of the Company to make or authorize an adjustment, recapitalization or other change
in the capital structure or the business of the Company, any merger or consolidation of the Company or subsidiaries, any issue of bonds, debentures, preferred or prior preference stock ahead of or affecting the Common Stock, the dissolution or
liquidation of the Company, any sale or transfer of all or part of its assets or business or any other corporate act or proceeding. 
 10.3.
The Participant agrees that the award of the Performance Share Award hereunder, and upon any settlement thereof the issuance of Restricted Stock (if any), is special incentive compensation and that the Performance Share Award and Restricted Stock
(if applicable), any dividends paid thereon (even if treated as compensation for tax purposes) and any other RS Property will not be taken into account as “salary” or “compensation” or “bonus” in determining the amount
of any payment under any pension, retirement or profit-sharing plan of the Company or any life insurance, disability or other benefit plan of the Company. 

10.4. No modification or waiver of any of the provisions of this Agreement shall be effective unless in writing and signed by the party against
whom it is sought to be enforced. 
 10.5. This Agreement may be executed in one or more counterparts (including via facsimile or PDF), all
of which taken together shall constitute one contract. 
 10.6. The failure of any party hereto at any time to require performance by another
party of any provision of this Agreement shall not affect the right of such party to require performance of that provision, and any waiver by any party of any breach of any provision of this Agreement shall not be construed as a waiver of any
continuing or succeeding breach of such provision, a waiver of the provision itself, or a waiver of any right under this Agreement. 

  
 -8- 

 10.7. The headings of the sections of this Agreement have been inserted for convenience of
reference only and shall in no way restrict or modify any of the terms or provisions hereof. 
 10.8. All notices, consents, requests,
approvals, instructions and other communications provided for herein shall be in writing and validly given or made when delivered, or on the second succeeding business day after being mailed by registered or certified mail, whichever is earlier, to
the persons entitled or required to receive the same, at the addresses set forth at the heading of this Agreement or to such other address as either party may designate by like notice. Notices to the Company shall be addressed to the Compensation
Committee of the Board with a copy to the Company’s Head of Human Resources. 
 10.9. This Agreement shall be construed, interpreted and
governed and the legal relationships of the parties determined in accordance with the internal laws of the State of Delaware without reference to rules relating to conflicts of law. 

10.10. By executing this Agreement the Participant hereby accepts the terms and conditions of this Agreement and, effective as of the
Settlement Date, shall be deemed to have accepted the award of Restricted Stock within the time period required under Section 8.2(b) of the Plan. 

11. Provisions of Plan Control. This Agreement is subject to all the terms, conditions and provisions of the Plan,
including, without limitation, the amendment provisions thereof, and to such rules, regulations and interpretations relating to the Plan as may be adopted by the Committee and as may be in effect from time to time. The Plan is incorporated herein by
reference. A copy of the Plan has been delivered to the Participant. If and to the extent that this Agreement conflicts or is inconsistent with the terms, conditions and provisions of the Plan, the Plan shall control, and this Agreement shall be
deemed to be modified accordingly. Unless otherwise indicated, any capitalized term used but not defined herein shall have the meaning ascribed to such term in the Plan. This Agreement contains the entire understanding of the parties with respect to
the subject matter hereof (other than any other documents expressly contemplated herein or in the Plan) and supersedes any prior agreements between the Company and the Participant. 

[Signature Page Follows] 

  
 -9- 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the day and year first above written. 
  

			
	MARKETAXESS HOLDINGS INC.
		
	By:	 	 /s/ Antonio L. DeLise

	 Name: Antonio L. DeLise

	 Title:   Chief Financial Officer

	
	 /s/ Richard M. McVey

	  
 Richard M.
McVey

  
 -10- 

 APPENDIX A 

Performance Metric and Number of Shares 

The performance metric set forth herein is established for purposes of the grant of the Performance Shares for the Performance Period. 

The performance metric shall be, and the number of shares of Common Stock awarded (the “Awarded Shares”) will be based on and
subject to, the Company’s level of attainment of an average price per share of the Common Stock achieved calculated based on the closing price of the Common Stock over any twenty (20) consecutive trading days during the Performance Period,
rounded up to the nearest whole cent (“Average Stock Price”) as specified below. 
 Subject to the terms and conditions of
this Agreement, the number of Awarded Shares to be issued to the Participant on a Settlement Date shall be as follows: 
  

			
	 Average Stock Price Achieved

(“Performance Level”)
	  	
Number of Awarded Shares
	 Below $257.78
	  	0
	 At or above $257.78 per share
	  	The number of Performance Shares set
 forth in Section 1 of the
Agreement

 The performance metric set forth on this Appendix A is subject to adjustment under Section 4.2(b) of the Plan.

  
 A-1

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