Document:

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                                                                   Exhibit 10.45

                           CHANGE-IN-CONTROL AGREEMENT

               AGREEMENT by and between INVITROGEN CORPORATION, a Delaware
Corporation (the "Company"), and John A. Cottingham (the "Executive"), dated as
of the 7th day of June 2002.

               The Board of Directors of the Company (the "Board"), has
determined that it is in the best interests of the Company and its stockholders
to assure that the Company will have the continued dedication of the Executive,
notwithstanding the possibility, threat or occurrence of a Change in Control (as
defined below). The Board believes it is imperative to diminish the inevitable
distraction of the Executive by virtue of the personal uncertainties and risks
created by a pending or threatened Change in Control and to encourage the
Executive's full attention and dedication to the Company currently and in the
event of any threatened or pending Change in Control, and to provide the
Executive with compensation and benefits arrangements upon a Change in Control
which ensure that the compensation and benefits expectations of the Executive
will be satisfied and which are competitive with those of other corporations.
Therefore, in order to accomplish these objectives, the Board has caused the
Company to enter into this Agreement.

               NOW, THEREFORE, IT IS HEREBY AGREED AS FOLLOWS:

               1. Certain Definitions.

                      (a) The "Effective Date" shall be the first date during
the "Change in Control Period" (as defined in Section l(b)) on which a Change in
Control occurs; provided that the Executive is employed on that date. Anything
in this Agreement to the contrary notwithstanding, if the Executive's employment
with the Company is terminated or the Executive ceases to be an officer of the
Company prior to the date on which a Change in Control occurs, and it is
reasonably demonstrated by the Executive that such termination of employment or
cessation of status as an officer (i) was at the request of a third party who
has taken steps reasonably calculated to effect the Change in Control or (ii)
otherwise arose in connection with or anticipation of the Change in Control,
then for all purposes of this Agreement the "Effective Date" shall mean the date
immediately prior to the date of such termination of employment or cessation of
status as an officer.

                      (b) The "Change in Control Period" is the period
commencing on the date hereof and ending on the second anniversary of such date,
provided, however, that commencing on the date one year after the date hereof,
and on each annual anniversary of such date (such date and each annual
anniversary thereof is hereinafter referred to as the "Renewal Date"), the
Change in Control Period shall be automatically extended so as to terminate two
years from such Renewal Date, unless at least 60 days prior to the Renewal Date
the Company shall give notice to the Executive that the Change in Control Period
shall not be so extended.

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               2. Change in Control. For the purpose of this Agreement;

                      (a) a "Change in Control" shall mean:

                             (i) Any acquisition or series of acquisitions,
other than from the Company, by any individual, entity or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934,
as amended (the "Exchange Act")) of beneficial ownership (within the meaning of
Rule 13d-3 under the Exchange Act) of 50% or more of either the then outstanding
shares of common stock of the Company (the "Outstanding Company Common Stock")
or the combined voting power of the then outstanding voting securities of the
Company entitled to vote generally in the election of directors (the
"Outstanding Company Voting Securities"), provided, however, that (A) any
acquisition by the Company, or any of its subsidiaries, (B) any acquisition by
any employee benefit plan (or related trust) sponsored or maintained by the
Company or any of its subsidiaries, or (C) any acquisition or series of
acquisitions which results in any individual, entity or group (within the
meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act) acquiring
beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act)
of more than 50% of the Outstanding Company Common Stock and while such a
beneficial owner such individual, entity or group does not exercise the voting
power of his, her or its Outstanding Company Common Stock or otherwise exercise
control with respect to any matter concerning or affecting the Company and
promptly sells, transfers, assigns or otherwise disposes of that number of
shares of Outstanding Company Common Stock necessary to reduce his, her or its
beneficial ownership (within the meaning of Rule 13d-3 under the Exchange Act)
of the Outstanding Company Common Stock to below 50%, as the case may be, shall
not constitute a Change in Control; or

                             (ii) Individuals who as of April 27, 2001,
constitute the Board of Directors of the Company (the "Incumbent Board") cease
for any reason to constitute at least a majority of the Board of Directors of
the Company, provided that any individual becoming a director subsequent to
April 27, 2001, whose election, or nomination for election, by the Company's
stockholders was approved by a vote of at least a majority of the directors then
comprising the Incumbent Board, shall be considered as though such individual
were a member of the Incumbent Board, but excluding, for this purpose, any such
individual whose initial assumption of office is in connection with an actual or
threatened election contest (as such terms are used in Rule 14a-11 of the
Regulation 14A promulgated under the Exchange Act) relating to the election of
directors of the Company; or

                             (iii) Approval by the stockholders of the Company
of a complete liquidation or dissolution of the Company, or of the sale or other
disposition of all or substantially all of the assets of the Company, or of a
reorganization, merger or consolidation of the Company, in each case, with
respect to which all or substantially all of the individuals and entities who
were the respective beneficial owners of the Outstanding Company Common Stock
and Outstanding Company Voting Securities immediately prior to such
reorganization, merger or consolidation do not, following such reorganization,
merger or consolidation beneficially own, directly or indirectly, more than 60%
of, respectively, the then outstanding shares of common stock

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and the combined voting power of the then outstanding voting securities entitled
to vote generally in the election of directors, as the case may be, of the
corporation resulting from such reorganization, merger or consolidation.

               3. Employment Period. The Company hereby agrees to continue the
Executive in its employ, and the Executive hereby agrees to remain in the employ
of the Company, for the period commencing on the Effective Date and ending at
the end of the 24th month following the Effective Date (the "Employment
Period").

               4. Terms of Employment

                      (a) Position and Duties.

                             (i) During the Employment Period, (A) the
Executive's position, authority, duties and responsibilities shall not be
substantially diminished from the most significant of those held, exercised and
assigned at any time during the 90-day period immediately preceding the
Effective Date and (B) the Executive's services shall be performed at the
location where the Executive was employed immediately preceding the Effective
Date or any office or location less than 50 miles from such location.

                             (ii) During the Employment Period, and excluding
any periods of vacation and sick leave to which the Executive is entitled, the
Executive agrees to devote reasonable attention and time during normal business
hours to the business and affairs of the Company and, to the extent necessary to
discharge the responsibilities assigned to the Executive hereunder, to use the
Executive's reasonable best efforts to perform faithfully and efficiently such
responsibilities. During the Employment Period it shall not be a violation of
this Agreement for the Executive to (A) serve on corporate, civic or charitable
boards or committees, (B) deliver lectures, fulfill speaking engagements or
teach at educational institutions and (C) manage personal investments, so long
as such activities do not significantly interfere with the performance of the
Executive's responsibilities as an employee of the Company in accordance with
this Agreement. It is expressly understood and agreed that to the extent that
any such activities have been conducted by the Executive prior to the Effective
Date, the continued conduct of such activities (or the conduct of activities
similar in nature and scope thereto) subsequent to the Effective Date shall not
thereafter be deemed to interfere with the performance of the Executive's
responsibilities to the Company.

                      (b) Compensation.

                             (i) Base Salary. During the Employment Period, the
Executive shall receive an annual base salary ("Annual Base Salary"), which
shall be paid at a monthly rate, at least equal to the highest annualized (for
any fiscal year consisting of less than twelve full months or with respect to
which the Executive has been employed by the Company for less than twelve full

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months) base salary paid or payable to the Executive by the Company and its
affiliated companies in respect of the three fiscal years immediately preceding
the fiscal year in which the Effective Date occurs. During the Employment
Period, the Annual Base Salary shall be reviewed at least annually and shall be
increased at any time and from time to time as shall be substantially consistent
with increases in base salary generally awarded in the ordinary course of
business to other peer executives of the Company and its affiliated companies.
Any increase in Annual Base Salary shall not serve to limit or reduce any other
obligation to the Executive under this Agreement. Annual Base Salary shall not
be reduced after any such increase and the term Annual Base Salary as utilized
in this Agreement shall refer to the Annual Base Salary as so increased. As used
in this Agreement, the term "affiliated companies" includes any company
controlled by, controlling or under common control with the Company.

                             (ii) Annual Bonus. In addition to Annual Base
Salary, the Executive shall be awarded, for each fiscal year during the
Employment Period, an annual bonus (the "Annual Bonus") in cash at least equal
to the higher of either (A) the average annualized (for any fiscal year
consisting of less than twelve full months or with respect to which the
Executive has been employed by the Company for less than twelve full months)
bonus paid, or payable but for any deferral to the Executive by the Company and
its affiliated companies under the Company's deferred compensation arrangements,
in respect of the three fiscal years immediately preceding the fiscal year in
which the Effective Date occurs, or (B) in the event the annual bonus paid, or
payable but for any deferral to the Executive by the Company and its affiliated
companies under the Company's deferred compensation arrangement, in respect of
the fiscal year immediately preceding the fiscal year in which the Effective
Date occurs was based upon a formula or plan in which the Executive
participated, then such Annual Bonus shall be at least equal to the bonus which
would be payable based on such formula or plan had the Executive's participation
therein and level of participation remained in effect following the Effective
Date. Each such Annual Bonus shall be paid no later than the end of the third
month of the fiscal year next following the fiscal year for which the Annual
Bonus is awarded, unless the Executive shall elect to defer the receipt of such
Annual Bonus.

                             (iii) Incentive, Savings and Retirement Plans. In
addition to Annual Base Salary and Annual Bonus payable as hereinabove provided,
the Executive shall be entitled to participate during the Employment Period in
all incentive, savings and retirement plans, practices, policies and programs
generally applicable to other peer executives of the Company and its affiliated
companies, but in no event shall such plans, practices, policies and programs
provide the Executive with incentive opportunities (measured with respect to
both regular and special incentive opportunities), savings opportunities and
retirement benefits opportunities, in each case, less favorable, in the
aggregate, than the most favorable of those provided by the Company and its
affiliated companies for the Executive under such plans, practices, policies and
programs as in effect at any time during the 90-day period immediately preceding
the Effective Date.

                             (iv) Welfare Benefit Plans. During the Employment
Period, the Executive and/or the Executive's family, as the case may be, shall
be eligible for participation in and shall receive all benefits under welfare
benefit plans, practices, policies and programs provided by the Company and its
affiliated companies (including, without limitation, medical, prescription,

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dental, disability, salary continuance, employee life, group life, accidental
death and travel accident insurance plans and programs) to the extent generally
applicable to other peer executives of the Company and its affiliated companies,
but in no event shall such plans, practices, policies and programs provide
benefits which are less favorable, in the aggregate, than the most favorable of
such plans, practices, policies and programs in effect for the Executive and/or
the Executive's family at any time during the 90-day period immediately
preceding the Effective Date.

                             (v) Business Expenses. During the Employment
Period, the Executive shall be entitled to receive prompt reimbursement for all
reasonable business expenses incurred by the Executive in accordance with the
most favorable policies, practices and procedures of the Company and its
affiliated companies in effect for the Executive at any time during the 90-day
period immediately preceding the Effective Date or, if more favorable to the
Executive, as in effect at any time thereafter generally with respect to other
peer executives of the Company and its affiliated companies.

                             (vi) Fringe Benefits. During the Employment Period,
the Executive shall be entitled to fringe benefits in accordance with the most
favorable plans, practices, programs and policies of the Company and its
affiliated companies in effect for the Executive at any time during the 90-day
period immediately preceding the Effective Date or, if more favorable to the
Executive, as in effect at any time thereafter generally with respect to other
peer executives of the Company and its affiliated companies.

                             (vii) Office and Support Staff. During the
Employment Period, the Executive shall be entitled to an office or offices of a
size and with furnishings and other appointments, and to personal secretarial
and other assistance, at least equal to the most favorable of the foregoing
provided to the Executive by the Company and its affiliated companies at any
time during the 90-day period immediately preceding the Effective Date or, if
more favorable to the Executive, as provided at any time thereafter generally
with respect to other peer executives of the Company and its affiliated
companies.

                             (viii) Vacation. During the Employment Period, the
Executive shall be entitled to paid vacation in accordance with the most
favorable plans, policies, programs and practices of the Company and its
affiliated companies as in effect for the Executive at any time during the
90-day period immediately preceding the Effective Date or, if more favorable to
the Executive, as in effect at any time thereafter generally with respect to
other peer executives of the Company and its affiliated companies.

               5. Termination of Employment

                      (a) Death or Disability. The Executive's employment shall
terminate automatically upon the Executive's death during the Employment Period.
If the Company determines in good faith that the Disability (as defined below)
of the Executive has occurred during the Employment Period, it may give to the
Executive written notice in accordance with Section 15(b) of this Agreement of
its intention to terminate the Executive's employment. In such event, the
Executive's employment with the Company shall terminate effective on the 30th
day after receipt of

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such notice by the Executive (the "Disability Effective Date"), provided that,
within the 30 days after such receipt, the Executive shall not have returned to
full-time performance of the Executive's duties. For purposes of this Agreement,
"Disability" means the absence of the Executive from the Executive's duties with
the Company on a full-time basis for 180 consecutive business days as a result
of incapacity due to mental or physical illness which is determined to be total
and permanent by a physician selected by the Company or its insurers and
acceptable to the Executive or the Executive's legal representative (such
agreement as to acceptability not to be withheld unreasonably).

                      (b) Cause. The Company may terminate the Executive's
employment during the Employment Period for "Cause." For purposes of this
Agreement, "Cause" means (i) repeated violations by the Executive of the
Executive's responsibilities and duties under Section 4(a) of this Agreement
which are demonstrably willful and deliberate on the Executive's part and which
are not remedied in a reasonable period of time after receipt of written notice
from the Company, (ii) commission of an intentional act of fraud, embezzlement
or theft by the Executive in connection with the Executive's duties or in the
course of the Executive's employment with the Company or its affiliated
companies, (iii) causing intentional wrongful damage to property of the Company
or its affiliated companies, (iv) intentionally and wrongfully disclosing secret
processes or confidential information of the Company or its affiliated
companies, or (v) participating, without the Company's express written consent,
in the management of any business enterprise which engages in substantial and
direct competition with the Company or its affiliated companies, and any such
act shall have been materially harmful to the Company or its affiliated
companies.

                      (c) Good Reason. The Executive's employment may be
terminated during the Employment Period by the Executive for "Good Reason." For
purposes of this Agreement, "Good Reason" means

                             (i) a substantial diminution in the Executive's
position, authority, duties or responsibilities as contemplated by Section 4(a)
of this Agreement, excluding non-substantial changes in title or office, and
excluding any isolated, insubstantial and inadvertent action not taken in bad
faith and which is remedied by the Company promptly after receipt of written
notice thereof given by the Executive;

                             (ii) any failure by the Company to comply with any
of the provisions of Section 4(b) of this Agreement, other than an isolated,
insubstantial and inadvertent failure not occurring in bad faith and which is
remedied by the Company promptly after receipt of written notice thereof given
by the Executive;

                             (iii) the Company requiring the Executive to be
based at any office or location other than that described in Section 4(a)(i)(B)
hereof or, requiring the Executive to travel away from his or her office in the
course of discharging responsibilities or duties in a manner which is
inappropriate for the performance of the Executive's duties hereunder and which
is significantly more frequent (in terms of either consecutive days or aggregate
days in any calendar year) than was required prior to the Change in Control;

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                             (iv) any purported termination by the Company of
the Executive's employment otherwise than as expressly permitted by this
Agreement; or

                             (v) any failure by any successor to the Company to
comply with and satisfy Section 14(c) of this Agreement, provided that such
successor has received at least ten (10) days prior written notice from the
Company or the Executive of the requirements of Section 14(c) of this Agreement.

For the purposes of this Section 5(c), any good faith determination of "Good
Reason" made by the Executive shall be conclusive.

                      (d) Notice of Termination. Any termination by the Company
for Cause or by the Executive for Good Reason shall be communicated by "Notice
of Termination" to the other party hereto given in accordance with Section 15(b)
of this Agreement. For purposes of this Agreement, a "Notice of Termination"
means a written notice which (i) indicates the specific termination provision in
this Agreement relied upon, (ii) to the extent applicable, sets forth in
reasonable detail the facts and circumstances claimed to provide a basis for
termination of the Executive's employment under the provision so indicated and
(iii) if the Date of Termination (as defined below) is other than the date of
receipt of such notice, specifies the termination date (which date shall be not
more than fifteen days after the giving of such notice). The failure by the
Executive or the Company to set forth in the Notice of Termination any fact or
circumstance which contributes to a showing of Good Reason or Cause, as the case
may be, shall not waive any right of the Executive or the Company hereunder or
preclude the Executive or the Company from asserting such fact or circumstance
in enforcing the Executive's or the Company's rights hereunder.

                      (e) Date of Termination. "Date of Termination" means the
date of receipt of the Notice of Termination or any later date specified
therein, as the case may be; provided, however, that (i) if the Executive's
employment is terminated by the Company other than for Cause or Disability, the
Date of Termination shall be the date on which the Company notifies the
Executive of such termination and (ii) if the Executive's employment is
terminated by reason of death or Disability, the Date of Termination shall be
the date of death of the Executive or the Disability Effective Date, as the case
may be.

               6. Obligations of the Company upon Termination

                      (a) Death. If the Executive's employment is terminated by
reason of the Executive's death during the Employment Period, this Agreement
shall terminate without further obligations to the Executive's legal
representatives under this Agreement, other than the following obligations: (i)
payment of the Executive's Annual Base Salary through the Date of Termination to
the extent not theretofore paid, (ii) payment of the product of (x) the Annual
Bonus paid or payable but for any deferral (and annualized for any fiscal year
consisting of less than twelve full months or for which the Executive has been
employed for less than twelve full months) to the Executive for the most
recently completed fiscal year during the Employment Period, and (y) a fraction,
the numerator of which is the number of days in the current fiscal year through
the Date of Termination, and the denominator of which is 365 and (iii) payment
of any compensation

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previously deferred by the Executive (together with any accrued interest
thereon) and not yet paid by the Company and any accrued vacation pay not yet
paid by the Company (the amounts described in clauses (i), (ii) and (iii) above
are hereafter referred to as "Accrued Obligations"). All Accrued Obligations
shall be paid to the Executive's estate or beneficiary, as applicable, at the
option of the Company, either (x) in a lump sum in cash within 30 days of the
Date of Termination or (y) in twelve equal consecutive monthly installments,
with the first installment to be paid within 30 days of the Date of Termination.
Anything in this Agreement to the contrary notwithstanding, the Executive's
family shall be entitled to receive benefits at least equal to the most
favorable benefits provided generally by the Company and any of its affiliated
companies to surviving families of peer executives of the Company and such
affiliated companies under such plans, programs, practices and policies relating
to family death benefits, if any, as in effect generally with respect to other
peer executives and their families at any time during the 90-day period
immediately preceding the Effective Date or, if more favorable to the Executive
and/or the Executive's family as in effect on the date of the Executive's death
generally with respect to other peer executives of the Company and its
affiliated companies and their families.

                      (b) Disability. If the Executive's employment is
terminated by reason of the Executive's Disability during the Employment Period,
this Agreement shall terminate without further obligations to the Executive,
other than for Accrued Obligations. All Accrued Obligations shall be paid to the
Executive at the option of the Company, either (x) in a lump sum in cash within
30 days of the Date of Termination or (y) in twelve equal consecutive monthly
installments, with the first installment to be paid within 30 days of the Date
of Termination. Anything in this Agreement to the contrary notwithstanding, the
Executive shall be entitled after the Disability Effective Date to receive
disability and other benefits at least equal to the most favorable of those
provided by the Company and its affiliated companies to disabled peer executives
and/or their families in accordance with such plans, programs, practices and
policies relating to disability, if any, as in effect generally with respect to
other peer executives and their families at any time during the 90-day period
immediately preceding the Effective Date or, if more favorable to the Executive
and/or the Executive's family, as in effect at any time thereafter through the
Date of Termination generally with respect to other peer executives of the
Company and its affiliated companies and their families.

                      (c) Cause. If the Executive's employment shall be
terminated for Cause during the Employment Period, this Agreement shall
terminate without further obligations to the Executive other than the obligation
to pay to the Executive the Annual Base Salary through the Date of Termination
plus the amount of any compensation previously deferred by the Executive, in
each case to the extent theretofore unpaid. If the Executive terminates
employment during the Employment Period, excluding a termination for Good
Reason, this Agreement shall terminate without further obligations to the
Executive, other than for Accrued Obligations. In such case, all Accrued
Obligations shall be paid to the Executive at the option of the Company, either
(x) in a lump sum in cash within 30 days of the Date of Termination, or (y) in
twelve equal consecutive monthly installments, with the first installment to be
paid within 30 days of the Date of Termination.

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                      (d) Good Reason. If, during the Employment Period, the
Company shall terminate the Executive's employment other than for Cause or
Disability, or the Executive shall terminate employment under this Agreement for
Good Reason:

                             (i) the Company shall pay to the Executive the
aggregate of the following amounts, such amounts to be payable by the Company in
a lump sum in cash within 30 days of the Date of termination.

                                    A. All Accrued Obligations; and

                                    B. 2.0 times the sum of the Executive's
Annual Base Salary and the higher of either (i) the average annualized (for any
fiscal year consisting of less than twelve full months or with respect to which
the Executive has been employed by the Company for less than twelve full months)
bonus paid, or payable but for any deferral to the Executive by the Company and
its affiliated companies under the Company's deferred compensation arrangements,
in respect of the three fiscal years immediately preceding the fiscal year in
which the Effective Date occurs, or (ii) the targeted annual bonus payable to
the Executive pursuant to the Company's Incentive Compensation Plan for the
fiscal year in which the Date of Termination occurs (assuming 100% achievement
of the Company performance factor and 100% achievement of the Executive's
personal performance factor; and

                                    C. An amount equal to that portion, if any,
of the Company's contribution to the Executive's 401(k), savings or other
similar individual account plan which is not vested as of the Date of
Termination (the "Unvested Company Contribution"), plus an amount which when
added to the Unvested Company Contribution would be sufficient after Federal,
state and local income taxes (based on the tax returns filed by the Executive
most recently prior to the Date of Termination) to enable the Executive to net
an amount equal to the Unvested Company Contribution; and

                             (ii) the Company shall pay the Executive up to
$25,000 for executive outplacement services utilized by the Executive upon the
receipt by the Company of written receipts or other appropriate documentation;
and

                             (iii) for the remainder of the Employment Period,
or such longer period as any plan, program, practice or policy may provide, the
Company shall continue benefits to the Executive and, where applicable, the
Executive's family at least equal to those which would have been provided to
them in accordance with the plans, programs, practices and policies described in
Section 4(b)(iv) of this Agreement if the Executive's employment had not been
terminated in accordance with the most favorable plans, practices, programs or
policies of the Company and its affiliated companies generally applicable to
other peer executives and their families during the 90-day period immediately
preceding the Effective Date or, if more favorable to the Executive, as in
effect at any time thereafter generally with respect to other peer executives of
the Company and its affiliated companies and their families; provided, however,
that if the

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Executive becomes employed elsewhere during the Employment Period and is thereby
afforded comparable insurance and welfare benefits to those described in Section
4(b)(iv), the Company's obligation to continue providing the Executive with such
benefits shall cease or be correspondingly reduced, as the case may be. For
purposes of determining eligibility of the Executive for retiree benefits
pursuant to such plans, practices, programs and policies, the Executive shall be
considered to have remained employed until the end of the Employment Period and
to have retired on the last day of such period; and

                             (iv) All outstanding stock options held by the
Executive pursuant to any Company stock option plan shall immediately become
vested and exercisable as to all or any part of the shares covered thereby, with
the Executive being able to exercise his or her stock options within a period of
three months following the Date of Termination or such longer period as may be
permitted under Executive's stock option agreements; and

                             (v) If, in the calendar year immediately preceding
the Date of Termination, the Executive had relocated the Executive's primary
residence from one location (the "Point of Origin") to its location at the Date
of Termination at the request of the Company, then any relocation expenses that
are actually incurred in the year immediately following the Date of Termination
by the Executive in moving the Executive's primary residence to any location
shall be reimbursed by the Company to the extent such expenses do not exceed the
cost of relocating the Executive's primary residence to the Point of Origin,
provided such expenses are substantiated by means of written receipts. The cost
of relocating the Executive's primary residence to the Point of Origin shall be
determined by averaging estimates obtained by the Company in writing from three
reputable moving companies, selected by the Company in good faith. It shall be
the obligation of the Executive to notify the Company in advance of any such
relocation so that such estimates may be obtained.

The amounts required to be paid under this Section 6(d) shall be reduced by any
other amount of severance (i.e., relating solely to salary or bonus continuation
or actual or deemed pension or insurance continuation) received by the Executive
upon such termination of employment under any severance plan, policy or
arrangement of the Company applicable to the Executive or a group of employees
of the Company, including the Executive, and applicable without regard to the
occurrence of a Change in Control prior to such termination of employment. The
amounts payable to the Executive pursuant to this Agreement will not be subject
to any requirement of mitigation, nor, except as specifically set forth herein,
will they be offset or otherwise reduced by reason of the Executive's receipt of
compensation from any source other than the Company.

               7. Non-exclusivity of Rights. Nothing in this Agreement shall
prevent or limit the Executive's continuing or future participation in any
benefit, bonus, incentive or other plans, programs, policies or practices
provided by the Company or any of its affiliated companies and for which the
Executive may qualify, nor shall anything herein limit or otherwise affect such
rights as the Executive may have under any other agreements with the Company or
any of its affiliated companies. Amounts which are vested benefits or which the
Executive is otherwise entitled to receive under any plan, policy, practice or
program of the Company or any of its affiliated

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companies at or subsequent to the Date of Termination shall be payable in
accordance with such plan, policy, practice or program except as explicitly
modified by this Agreement.

               8. Full Settlement. The Company's obligation to make the payments
provided for in this Agreement and otherwise to perform its obligations
hereunder, except as provided in the last sentence of Section 6(d), shall not be
affected by any set-off, counterclaim, recoupment, defense or other claim, right
or action which the Company may have against the Executive or others. In no
event shall the Executive be obligated to seek other employment or take any
other action by way of mitigation of the amounts payable to the Executive under
any of the provisions of this Agreement. The Company agrees to pay, to the full
extent permitted by law, all legal fees and expenses which the Executive may
reasonably incur, including the costs and expenses of any arbitration
proceeding, as a result of any contest (regardless of the outcome thereof) by
the Company or others of the validity or enforceability of, or liability under,
any provision of this Agreement or any guarantee of performance thereof
(including as a result of any content by the Executive about the amount of any
payment pursuant to this Agreement), plus in each case interest on any delayed
payment at the applicable Federal rate provided for in Section 7872(f)(2) of the
Internal Revenue Code of 1986, as amended (the "Code"); provided that the
Executive's claim is not determined by a court of competent jurisdiction or an
arbitrator to be frivolous or otherwise entirely without merit.

               9. Release. Upon fulfillment of the Company's obligation to make
the payments provided for in this Agreement and otherwise to perform its
obligations hereunder, the Executive fully and unconditionally releases and
discharges all claims and causes of action which the Executive or his or her
heirs, personal representatives, successors, or assigns ever had, now have, or
hereafter may have against the Company and any of its affiliated companies on
account of any claims and causes of action arising out of or relating to this
Agreement, any other document relating hereto or delivered in connection with
the transactions contemplated hereby.

               10. Certain Additional Payments by the Company.

                      (a) Anything in this Agreement to the contrary
notwithstanding, in the event it shall be determined that, as a result, directly
or indirectly, of the operation of any of the Company's existing stock option
plans, or any successor option or restricted stock plans (collectively, the
"Option and Restricted Stock Acceleration"), either standing alone or taken
together with the receipt of any other payment or distribution by the Company to
or for the benefit of the Executive whether paid or payable or distributed or
distributable pursuant to the terms of this Agreement or otherwise (a "Payment")
the Executive would be subject to the excise tax imposed by Section 4999 of the
Code or any interest or penalties are incurred by the Executive with respect to
such excise tax (such excise tax, together with any such interest and penalties,
are hereinafter collectively referred to as the "Excise Tax"), then the amount
payable to the Executive hereunder or as a result of the Option and Restricted
Stock Acceleration shall be reduced in an amount that would result in the
Executive being in the most advantageous net after-tax position (taking into
account both income taxes and any Excise Tax). For purposes of this
determination, the "base amount" as defined in Section 280G(b)(3)(A) of the Code
shall be allocated between the Option

                                       11
<PAGE>

and Restricted Stock Acceleration, on the one hand, and Payments, on the other
hand, in accordance with Section 280G(b)(3)(B) of the Code.

                      (b) All determinations required to be made under this
Section, including the amount of any reduction that will be made in the payments
made pursuant to this Agreement and the assumptions to be utilized in arriving
at such determinations, shall be made by PricewaterhouseCoopers LLP (the
"Accounting Firm") which shall provide detailed supporting calculations both to
the Company and the Executive. All fees and expenses of the Accounting Firm for
tax and accounting advice provided to the Executive, up to a maximum of $15,000,
shall be borne solely by the Company. If the Accounting Firm determines that no
Excise Tax is payable by the Executive, it shall furnish the Executive with an
opinion that failure to report the Excise Tax on the Executive's applicable
federal income tax return would not result in the imposition of a negligence or
similar penalty. Any determination by the Accounting Firm shall be binding upon
the Company and the Executive.

               11. Confidential Information. The Executive shall hold in a
fiduciary capacity for the benefit of the Company all secret or confidential
information, knowledge or data relating to the Company or any of its affiliated
companies and their respective businesses, which shall have been obtained by the
Executive during the Executive's employment by the Company or any of its
affiliated companies and which shall not be or become public knowledge (other
than by acts by the Executive or representatives of the Executive in violation
of this Agreement). After termination of the Executive's employment with the
Company, the Executive shall not, without the prior written consent of the
Company, communicate or divulge any such information, knowledge or data to
anyone other than the Company and those designated by it. In addition, to the
extent that the Executive is a party to any other agreement relating to
confidential information, inventions or similar matters with the Company, the
Executive shall continue to comply with the provisions of such agreements. In no
event shall an asserted violation of the provisions of this Section constitute a
basis for deferring or withholding any amounts otherwise payable to the
Executive under this Agreement.

               12. Public Announcements. The Executive shall consult with the
Company before issuing any press release or otherwise making any public
statement with respect to the Company or any of its affiliated companies, this
Agreement or the transactions contemplated hereby, and the Executive shall not
issue any such press release or make any such public statement without the prior
written approval of the Company, except as may be required by applicable law,
rule or regulation or any self regulatory agency requirements, in which event
the Company shall have the right to review and comment upon any such press
release or public statement prior to its issuance.

               13. Arbitration. Any dispute, controversy or claim arising out of
or relating to this Agreement, or any breach thereof, shall be determined and
settled by arbitration to be held in the City of New York pursuant to the labor
rules of the American Arbitration Association or any successor organization. Any
award rendered thereunder shall be final, conclusive and binding on the parties.
Subject to the provisions of Section 8 hereof, each party shall pay one-half of
all costs

                                       12
<PAGE>

and expenses of any arbitration proceeding brought pursuant to this Section, and
each party shall pay its own attorneys' fees and expenses.

               14. Successors.

                      (a) This Agreement is personal to the Executive and
without the prior written consent of the Company shall not be assignable by the
Executive otherwise than by will or the laws of descent and distribution. This
Agreement shall inure to the benefit of and be enforceable by the Executive's
legal representatives.

                      (b) This Agreement shall inure to the benefit of and be
binding upon the Company and its successors and assigns.

                      (c) The Company will require any successor (whether direct
or indirect, by purchase, merger, consolidation or otherwise) to all or
substantially all of the business and/or assets of the Company to assume
expressly and agree to perform this Agreement in the same manner and to the same
extent that the Company would be required to perform it if no such succession
had taken place. As used in this Agreement, "Company" shall mean the Company as
hereinbefore defined and any successor to its business and/or assets as
aforesaid which assumes and agrees to perform this Agreement by operation of
law, or otherwise.

               15. Miscellaneous

                      (a) This Agreement shall be governed by and construed in
accordance with the laws of the Sate of Delaware, without reference to
principles of conflict of laws. The captions of this Agreement are not part of
the provisions hereof and shall have no force or effect. This Agreement may not
be amended or modified otherwise than by a written agreement executed by the
parties hereto or their respective successors and legal representatives.

                      (b) All notices and other communications hereunder shall
be in writing and shall be given by hand delivery to the other party or by
registered or certified mail, return receipt requested, postage prepaid,
addressed as follows:

                             If to the Executive:

                             John A. Cottingham
                             7955 Sitio Solana
                             Carlsbad, CA 92009

                                       13
<PAGE>

                             If to the Company:

                             Invitrogen Corporation
                             1600 Faraday Avenue
                             Carlsbad, CA 92008
                             (ATTN:  General Counsel)

or to such other address as either party shall have furnished to the other in
writing in accordance herewith. Notice and communications shall be effective
when actually received by the addressee.

                      (c) The invalidity or unenforceability of any provision of
this Agreement shall not affect the validity or enforceability of any other
provision of this Agreement.

                      (d) The Company may withhold from any amounts payable
under this Agreement such Federal, state or local taxes as shall be required to
be withheld pursuant to any applicable law or regulation.

                      (e) The Executive's or the Company's failure to insist
upon strict compliance with any provision hereof in any particular instance
shall not be deemed to be a waiver of such provision or any other provision
thereof.

                      (f) This Agreement supersedes any previous agreement
between the Company and the Executive to the extent such agreement relates to
the subject matter hereof; provided, however, that this Agreement shall not
supersede that certain Settlement and Retention Agreement between the parties
dated as of June 7, 2002.

IN WITNESS WHEREOF, the Executive has hereunto set his or her hand and, pursuant
to the authorization from its Board of Directors, the Company has caused these
presents to be executed in its name on its behalf, all as of the day and year
first written above.

                                             INVITROGEN CORPORATION

/s/                                          By: /s/
-----------------------------------             --------------------------------
John A. Cottingham                              C. Eric Winzer
                                                Chief Financial Officer

                                       14<PAGE>

                                                                   Exhibit 10.46

         NOTICE: THIS NOTE IS SUBJECT TO SECTION 2966 OF THE CIVIL CODE, WHICH
         PROVIDES THAT THE HOLDER OF THIS NOTE SHALL GIVE WRITTEN NOTICE TO THE
         MAKERS OR TRUSTOR, OR HIS OR HER SUCCESSOR IN INTEREST, OF PRESCRIBED
         INFORMATION AT LEAST 90 AND NOT MORE THAN 150 DAYS BEFORE ANY BALLOON
         PAYMENT IS DUE.

                             SECURED PROMISSORY NOTE

                                                            Carlsbad, California
U.S. $__________                                                __________, 2002

        1. Obligation. The undersigned, _____________________________
("Employee") and _____________________________, husband and wife (hereinafter
referred to collectively as "Makers"), for value received, hereby promise to pay
to INVITROGEN CORPORATION, a Delaware corporation (hereinafter "Invitrogen" or
the "holder"), or order, as provided in Section 2 below or at such other place
as the holder may in writing direct, the original principal amount of
__________________ Thousand Dollars ($_________) without interest from the date
hereof until the Maturity Date (as defined below), and to the extent any such
principal amount remains outstanding on the Maturity Date Makers shall pay
interest thereon at the fixed rate of 10% per annum until paid in full.
Principal and interest (if applicable) shall be payable in lawful money of the
United States of America.

The principal amount of this Note shall be forgiven or the interest on such
amount shall be abated in certain circumstances, as follows:

               1.1 if Employee's employment with Invitrogen terminates
involuntarily without Cause (as defined below) on or before the fifth
anniversary of the date of this Note, this Note shall be fully forgiven
effective on the date of such termination;

               1.2 if Employee's employment with Invitrogen terminates
voluntarily (e.g., resignation) or involuntarily for Cause, the principal
balance of this Note shall not bear interest during any portion of the 180 days
after the date of such termination; and

            1.3 if Employee's employment with Invitrogen terminates due to death
or permanent disability, the provisions of Section 4 below shall control;

provided, that in any case specified in Subsections 1.1 to 1.3 above Employee or
Employee's estate shall have executed and delivered to Invitrogen a general
release (acceptable to Invitrogen in its sole discretion) waiving any and all
claims, known or unknown, liquidated or unliquidated, arising out of or in any
way related to Employee's employment with Invitrogen and/or termination of
employment. For purposes of this Note, employment shall be deemed terminated for
Cause if the termination is due to Employee's (i) theft, dishonesty, misconduct,
willful neglect of duties or falsification of any employment or Invitrogen
records; (ii) improper use or

<PAGE>

disclosure of Invitrogen's confidential or proprietary information; (iii)
conviction of any crime that impairs Employee's ability to perform his/her
duties for Invitrogen; or (iv) any action that has a detrimental effect on
Invitrogen's reputation or business, as determined in the sole and exclusive
discretion of Invitrogen.

        2. Payments. Any payments of interest due hereunder shall be payable in
monthly installments on the first day of every month. Unless the holder directs
otherwise, all payments made hereunder shall be made to Invitrogen, attention:
Controller, 1600 Faraday Avenue, Carlsbad, California 92008.

        3. Maturity

            3.1 The outstanding principal amount of the indebtedness evidenced
by this Note shall be due and payable on the earlier to occur of the date 180
days after the voluntary termination (e.g., resignation) of Employee's
employment with Invitrogen or 180 days after Employee's involuntary termination
for Cause (either of such dates referred to herein as the "Maturity Date"),
provided this Note has not been forgiven before such time pursuant to Subsection
1.1 or 3.2 or Section 4 hereof.

            3.2 If by the third anniversary of the date of this Note Employee's
employment with Invitrogen has not been terminated for any reason whatsoever,
then the outstanding principal balance of this Note shall be decreased as of the
third anniversary of the date of this Note by an amount equal to one-third of
the original principal balance of this Note (an amount equal to one-third of the
original principal balance of this Note is referred to herein as the
"Forgiveness Amount"), and if Employee's employment with Invitrogen has not been
terminated for any reason whatsoever as of the fourth and fifth anniversaries of
the date of this Note, then such principal amount shall be further decreased on
the fourth and fifth anniversaries of the date of this Note, respectively, by
the Forgiveness Amount such that this Note shall be fully forgiven as of the
fifth anniversary of the date of this Note. Notwithstanding the foregoing, any
such forgiveness of principal shall be expressly conditioned upon (i) Employee's
employment with Invitrogen as of the applicable anniversary date of this Note
and (ii) Employee's full satisfaction and compliance with Section 17 below.

        4. Death or Permanent Disability. Notwithstanding anything to the
contrary in this Note, (i) this Note shall be fully forgiven upon the death of
Employee prior to the Maturity Date and (ii) if the Employee becomes "Disabled"
(as defined below) the Forgiveness Amount shall be fully forgiven upon each of
the third, fourth, and fifth anniversary of the date of this Note; provided that
the Employee has been either employed by Invitrogen or Disabled during the
entire period beginning on the date of this Note and ending on each such
anniversary, respectively. The term "Disabled" means that the Employee is unable
to perform the essential functions of the position he or she holds in the
Company, with or without reasonable accommodation.

        5. Prepayment. This Note may be prepaid in whole or in part at any time
without penalty or premium. Any partial prepayment shall be credited first to
the most remote principal installment of this Note.

                                       2
<PAGE>

        6. Late Payment Charge. Makers agree to pay to the holder of this Note
an amount equal to 5% of any unpaid installment as a service charge on any such
monthly installment which is not paid within ten days of the date due.

        7. Costs of Collection. If this Note is not paid when due, whether at
maturity or by acceleration, Makers promise to pay all costs incurred by the
holder in collecting the amounts due hereunder, including attorneys' fees, and
all expenses incurred by the holder in connection with the protection of or
realization on the collateral securing this Note, whether or not suit is filed
herein; such costs and expenses shall include, without limitation, all costs,
reasonable attorneys' fees and expenses incurred by the holder in connection
with any insolvency, bankruptcy, reorganization, arrangement or other similar
proceedings involving Makers which in any way affects the exercise by the holder
of its rights and remedies under this Note or under any deed of trust, security
agreement or other agreement or instrument securing or pertaining to this Note.

        8. Secured Note. This Note is secured by a second priority deed of trust
of even date herewith (the "Deed of Trust") to First American Title Insurance
Company, as Trustee, executed by Makers in favor of Invitrogen encumbering
certain residential real property located at ______________, California and
purchased as Makers' principal residence (the "Principal Residence"). The Deed
of Trust shall be junior and subordinate to only a first priority deed of trust
in favor of ______________, securing indebtedness in an original principal
amount of $_________. Makers represent and warrant that all of the proceeds of
the indebtedness evidenced by this Note will be used to purchase the Principal
Residence.

        9. Default/Acceleration. At the option of the holder, without prior
notice, and regardless of any prior forbearance, all sums remaining unpaid under
this Note shall become immediately due and payable upon the occurrence of a
default by Makers under this Note. The occurrence of any of the following events
shall constitute a default by Makers under this Note:

               9.1 Makers' failure to pay any payment of interest or principal
when due under this Note, including, without limitation, Makers' failure to
satisfy in full all sums remaining unpaid under this Note on or before the
Maturity Date; or

               9.2 Makers' failure to perform any of Makers' other monetary and
nonmonetary covenants and agreements contained in this Note or the Deed of
Trust.

        10. Acceleration of Indebtedness. The Deed of Trust securing the
repayment of this Note provides for the acceleration of the Maturity Date upon
the happening of certain events, including the following:

                      "If Trustor shall sell, convey, lease or otherwise
               alienate the property, or any part thereof, or any interest
               therein, or shall be divested of its title or any interest
               therein in any manner or way, whether voluntarily or
               involuntarily, without the written consent of

                                       3
<PAGE>

               Beneficiary being first had and obtained, then Beneficiary shall
               have the right, at its option, except as prohibited by law, to
               declare any indebtedness or obligations secured hereby,
               irrespective of the maturity date specified in any note
               evidencing the same, immediately due and payable."

        11. Non-Transferable. Notwithstanding any provision contained herein to
the contrary, the benefits of the interest arrangements of this Note shall not
be transferable and shall be conditioned on Employee's future performance of
substantial services for Invitrogen within the meaning of Section 7872(f)(5) of
the Internal Revenue Code of 1986, as amended ("Code").

        12. Termination of Employment. In the event Employee's employment with
Invitrogen is terminated voluntarily or is terminated involuntarily for Cause
(i) the outstanding principal balance of this Note shall thereafter bear
interest at the fixed rate described in Section 1 above (subject to the
limitations described in Subsection 1.2 above) and (ii) all sums remaining
unpaid under this Note shall become due and payable on the date set forth in
Section 3 above, unless sooner accelerated or unless forgiven pursuant to
Subsection 3.2 or Section 4 above.

        13. Waiver. Makers hereby waive presentment, demand, protest, notices of
protest, dishonor and non-payment of this Note and all notices of every kind. No
delay or omission on the part of the holder in exercising any right hereunder
shall operate as a waiver of such right or of any other right under this Note.
The release of any party liable on this Note shall not operate to release any
other party liable hereon.

        14. Notice. Any notice or other communication which the holder may send
to Makers, or which Makers may send to the holder, shall be deemed delivered
three days following deposit of such notice or other communication in the United
States Mail, certified, return receipt requested, postage prepaid, addressed to
(i) the holder of this Note at the address set forth above or at such other
address as the holder may direct in writing, or (ii) Makers at the address set
forth in the Deed of Trust.

        15. Governing Law. Principal and interest are payable in lawful money of
the United States of America. This Note has been executed and delivered by
Makers in the State of California and shall be governed by and construed in
accordance with the laws of the State of California. In any action brought under
or arising out of this Note, Makers hereby consent to the jurisdiction of any
competent court within the State of California and consent to service of process
by any means authorized by California law.

        16. Income Tax Liabilities. Makers shall be solely and fully responsible
for any and all income tax liabilities or other consequences arising from or out
of this Note, including, without limitation, any such liabilities or
consequences arising from or out of Invitrogen's forgiveness of any principal or
interest evidenced hereby.

        17. Tax Withholding. Employee hereby authorizes withholding from payroll
and any other amounts payable to Employee, and otherwise agrees to pay to
Invitrogen or make other

                                       4
<PAGE>

adequate provision for any sums required to satisfy the federal, state, local
and foreign tax withholding obligations of Invitrogen, if any, which arise in
connection with this Note and the forgiveness of any principal or interest
evidenced hereby. Employee is cautioned that any forgiveness of principal
pursuant to Subsection 1.1 or 3.2 or Section 4 above shall be conditioned upon,
and shall not be effective unless and until any tax withholding obligations of
Invitrogen are satisfied.

                                            MAKERS:

                                            ------------------------------------

                                            ------------------------------------

                                       5
<PAGE>

                        RIDER TO SECURED PROMISSORY NOTE

                             EMPLOYEE CERTIFICATION

        I hereby certify that (i) I have been an employee of Invitrogen
Corporation since ______________, and that I presently am an employee of
Invitrogen Corporation, (ii) all of the proceeds of the loan evidenced by the
Note will be used to purchase a new principal residence for me and my family,
and (iii) I expect to be entitled to and will itemize deductions for United
States federal income tax purposes for each year during which the loan made to
me by Invitrogen Corporation is outstanding. This certification is made pursuant
to Temporary Regulation Section 1.7872-5T(c)(1) and Proposed Regulation Section
1.7872-5(c)(1). I will promptly notify Invitrogen Corporation in writing in the
event that I no longer itemize deductions for United States federal income tax
purposes.

Dated:______________________, 2002. ____________________________________________

                                       6

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