Document:

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                                                                   Exhibit 10.17

                                                                   Warrant No. 1

THIS WARRANT AND THE SHARES OF COMMON STOCK ISSUABLE UPON EXERCISE OF THIS
WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR APPLICABLE
STATE SECURITIES LAWS AND MAY NOT BE SOLD, TRANSFERRED, PLEDGED, HYPOTHECATED OR
OTHERWISE DISPOSED OF EXCEPT PURSUANT TO (1) REGISTRATION IN COMPLIANCE WITH
SUCH ACT AND SUCH STATE LAWS OR (2) AN OPINION OF COUNSEL REASONABLY
SATISFACTORY TO THE COMPANY TO THE EFFECT THAT SUCH REGISTRATION IS NOT
REQUIRED.

                                 COMMON STOCK WARRANT

                                  To Purchase 1,500
                              Shares of Common Stock of

                                  BIONEBRASKA, INC.

                                  September 2, 1993

       THIS CERTIFIES THAT, for good and valuable consideration, the receipt of
which is hereby acknowledged, _________________________ and
_________________________, JTWROS are entitled to subscribe for and purchase
from BioNebraska, Inc., a Delaware corporation (herein called the "Company"), at
any time after the date hereof to and including March 1, 1995, 1,500 fully paid
and nonassessable shares of the Company's common stock at an exercise price of
$6.50 per share, subject to adjustment as provided below.

       This Warrant is subject to the following provisions, terms and
conditions:

       1.     EXERCISE.  The rights represented by this Warrant may be exercised
by the holder hereof, in whole or in part (but not as to a fractional share of
common stock), by written notice of exercise delivered to the Company twenty
(20) days prior to the intended date of exercise and by the surrender of this
Warrant (properly endorsed if required) at the principal office of the Company
and upon payment to it by certified or cashier's check of the purchase price for
such shares.

       2.     ISSUANCE OF SHARES.  The Company agrees that the shares purchased
hereby shall be and are deemed to be issued to the record holder hereof as of
the close of business on the date on which this Warrant shall have been
surrendered and the payment made for such shares as aforesaid.  Subject to the
provisions of the next succeeding paragraph, certificates for the shares of
stock so

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purchased shall be delivered to the holder hereof within a reasonable
time, not exceeding ten (10) days after the rights represented by this Warrant
shall have been so exercised, and, unless this Warrant has expired, a new
Warrant representing the number of shares, if any, with respect to which this
Warrant shall not then have been exercised shall also be delivered to the holder
hereof within such time.

       Notwithstanding the foregoing, however, the Company shall not be required
to deliver any certificate for shares of stock upon exercise of this Warrant,
except in accordance with the provisions, and subject to the limitations, set
forth in the paragraphs below.

       3.     COVENANTS OF COMPANY.  The Company covenants and agrees that all
shares which may be issued upon the exercise of the rights represented by this
Warrant will, upon issuance, be duly authorized and issued, fully paid,
nonassessable and free from all taxes, liens and charges with respect to the
issue thereof, and without limiting the generality of the foregoing, the Company
covenants and agrees that it will from time to time take all such action as may
be required to assure that the par value per share of the common stock is at all
times equal to or less than the then effective purchase price per share of the
common stock issuable pursuant to this Warrant.  The Company further covenants
and agrees that during the period within which the rights represented by this
Warrant may be exercised, the Company will at all times have authorized, and
reserved for the purpose of issue or transfer upon exercise of the subscription
rights evidenced by this Warrant, a sufficient number of shares of its common
stock to provide for the exercise of the rights represented by this Warrant.

       4.     ANTI-DILUTION ADJUSTMENTS.  The above provisions are, however,
subject to the following:

       (a)    In case the Company shall at any time hereafter subdivide or
combine the outstanding shares of common stock or declare a dividend payable in
common stock, the exercise price of this Warrant in effect immediately prior to
the subdivision, combination or record date for such dividend payable in common
stock shall forthwith be proportionately increased, in the case of combination,
or decreased, in the case of subdivision or dividend payable in common stock,
and each share of common stock purchasable upon exercise of the Warrant shall be
changed to the number determined by dividing the then current exercise price by
the exercise price as adjusted after the subdivision, combination, or dividend
payable in common stock.

       (b)    No fractional shares of common stock are to be issued upon the
exercise of the Warrant, but the Company shall pay a cash adjustment in respect
of any fraction of a share which would otherwise be issuable in an amount equal
to the same fraction of the market price per share of common stock on the day of
exercise as determined in good faith by the Company.

       (c)    If any merger, capital reorganization or reclassification of the
capital stock of the Company, or consolidation or merger of the Company with
another corporation, or the sale of all or substantially all of its assets to
another corporation shall be effected in such a way that holders of

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common stock shall be entitled to receive stock, securities or assets with
respect to or in exchange for common stock then, as a condition of such
reorganization, reclassification, consolidation, merger or sale, lawful and
adequate provision shall be made whereby the holder hereof shall hereafter
have the right to purchase and receive upon the basis and upon the terms and
conditions specified in this Warrant and in lieu of the shares of the common
stock of the Company immediately theretofore purchasable and receivable upon
the exercise of the rights represented hereby, such shares of stock,
securities or assets as may be issued or payable with respect to or in
exchange for a number of outstanding shares of such common stock equal to the
number of shares of such stock immediately theretofore purchasable and
receivable upon the exercise of the rights represented hereby had such
reorganization, reclassification, consolidation, merger or sale not taken
place, and in any such case appropriate provisions shall be made with respect
to the rights and interests of the holder of this Warrant to the end that the
provisions hereof (including without limitation provisions for adjustments of
the Warrant purchase price and of the number of shares purchasable upon the
exercise of this Warrant) shall thereafter be applicable, as nearly as may
be, in relation to any shares of stock, securities or assets thereafter
deliverable upon the exercise hereof.  The Company shall not effect any such
consolidation, merger or sale, unless prior to the consummation thereof the
successor corporation (if other than the Company) resulting from such
consolidation or merger, or the corporation purchasing such assets, shall
assume by written instrument executed and mailed to the registered holder
hereof at the last address of such holder appearing on the books of the
Company, the obligation to deliver to such holder such shares of stock,
securities or assets as, in accordance with the foregoing provisions, such
holder may be entitled to purchase.

       (d)    The Company shall mail to the registered holder of the Warrant, at
his or her last known post office address appearing on the books of the Company,
not less than fifteen (15) days prior to the date on which (i) a record will be
taken for the purpose of determining the holders of Common Stock entitled to
dividends (other than cash dividends) or subscription rights, or (ii) a record
will be taken (or in lieu thereof, the transfer books will be closed) for the
purpose of determining the holders of Common Stock entitled to notice of and to
vote at a meeting of shareholders at which any capital reorganization,
reclassification of shares of Common Stock, consolidation, merger, dissolution,
liquidation, winding upon or sale of substantially all of the Company's assets
shall be considered and acted upon.

       (e)    Upon any adjustment of the warrant purchase price, then and in
each such case, the Company shall give written notice thereof, by first class
mail, postage prepaid, addressed to the registered holder of this Warrant at the
address of such holder as shown on the books of the Company, which notice shall
state the warrant purchase price resulting from such adjustment and the increase
or decrease, if any, in the number of shares purchasable at such price upon the
exercise of this Warrant, setting forth in reasonable detail the method of
calculation and the facts upon which such calculation is based.

       5.     COMMON STOCK.  As used herein, the term "common stock" shall mean
and include the Company's presently authorized shares of common stock and shall
also include any capital stock of any class of the Company hereafter authorized
which shall not be limited to a fixed sum or

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percentage in respect of the rights of the holders thereof to participate in
dividends or in the distribution of assets upon the voluntary or involuntary
liquidation, dissolution or winding up of the Company.

       6.     NO VOTING RIGHTS.  This Warrant shall not entitle the holder
hereof to any voting rights or other rights as a stockholder of the Company.

       7.     TRANSFER OF WARRANT OR RESALE OF SHARES.  The holder acknowledges
that it has obtained this Warrant for investment and not with the intention of
making any resale or distribution.  The holder further acknowledges (a) that
neither this Warrant nor any of the shares of common stock obtainable under it
have been registered under the Securities Act of 1933 or any state securities
statutes, and (b) that neither this Warrant nor any shares of common stock
obtained under it may be transferred without such registration or an opinion of
legal counsel acceptable to the Company that such transfer may be made without
registration.  The holder of this Warrant, by acceptance hereof, agrees to give
written notice to the Company before transferring this Warrant, or transferring
any common stock issued upon the exercise hereof, of such holder's intention to
do so, describing briefly the manner of any proposed transfer and accompanied by
an opinion of legal counsel, in form and substance satisfactory to the Company,
that the transfer may lawfully be made.  Promptly upon receiving such written
notice and opinion, the Company shall present copies thereof to the Company's
legal counsel and to counsel to the original purchaser of this Warrant.  If in
the opinion of each such counsel the proposed transfer may be effected without
registration or qualification under any Federal or State law, the Company, as
promptly as practicable, shall notify such holder of such opinion, whereupon
such holder shall be entitled to transfer this Warrant or to dispose of shares
of common stock received upon the previous exercise of this Warrant, provided
that an appropriate legend may be endorsed on this Warrant or the certificates
for such shares respecting restrictions upon transfer thereof necessary or
advisable in the opinion of the Company's legal counsel to prevent further
transfers which would be in violation of the Securities Act of 1933.

       If in the opinion of either of the counsel referred to in this paragraph
7 hereof, the proposed transfer or disposition of shares described in the
written notice given pursuant to this paragraph 7 may not be effected without
registration or qualification of this Warrant or the shares of common stock
issued on the exercise hereof, the Company shall promptly give written notice
thereof to the holder hereof, and such holder will limit its activities in
respect to such as, in the opinion of both such counsel, are permitted by law.

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       IN WITNESS WHEREOF, BioNebraska, Inc. has caused this Warrant to be
signed by its duly authorized officers and dated September 2, 1993.

                                                 BIONEBRASKA, INC.

                                                 By: /s/ Fred W. Wagner
                                                     --------------------------
                                                     Fred W. Wagner, President

ATTEST:

/s/ Thomas R. Coolidge
------------------------------
Thomas R. Coolidge, Secretary

                                       5<PAGE>

                                                                   Exhibit 10.18

                                                                      APPENDIX B

                                  WARRANT NO. ______
                          WARRANT FOR PURCHASE OF SHARES OF
                                     COMMON STOCK
                                 OF BIONEBRASKA, INC.
                                 ______________, 1997

       FOR VALUE RECEIVED, ______________________, or registered assigns (the
"Holder"), is entitled to purchase from BioNebraska, Inc., a Delaware
corporation (the "Company"), commencing on the maturity date, including any
extensions (the "Maturity Date") of the Subordinated Promissory Note issued by
the Company to the Holder pursuant to the Agreement referred to below (the
"Note"), and continuing until the fifth anniversary of the date of the original
issuance of this Warrant, __________ fully paid and nonassessable shares of the
Company's Common Stock, par value $.01 per share, (such class of stock being
hereinafter referred to as the "Common Stock" and such Common Stock as may be
acquired upon exercise hereof being hereinafter referred to as the "Warrant
Stock"), at an exercise price (the " Warrant Exercise Price") equal to (a)
eighty percent (80%) of the price to public of  initial public offering of the
Company's Common Stock which is effective on or before the Maturity Date, or (b)
$7.00 per share, in the event such public offering is not completed or is
completed after the Maturity Date.

       The Warrant has been issued to the Holder by the Company pursuant to the
Bridge Loan Agreement dated  of __________, 1997, by and between the Company and
the Holder (the "Agreement"), and is subject to the terms and provisions
thereof.

       This Warrant is subject to the following provisions, terms, and
conditions:

       1.   The rights represented by this Warrant may be exercised by the
Holder, in whole or in part (but not  to a fractional share of Common Stock),
by written notice of exercise substantially in the form attached hereto as
Schedule I, which notice shall be delivered to the Company accompanied by the
surrender of this Warrant (properly endorsed if required) at the principal
office of the Company and upon payment to the Company, by cash, certified
check or bank draft, of the Warrant Exercise Price for such shares.  The
Company agrees that the Warrant Stock so purchased shall be and is deemed to
be issued as of the close of business on the date on which this Warrant shall
have been surrendered and payment made for such Warrant Stock as aforesaid.
Certificates for the shares of Warrant Stock so purchased shall be delivered
to the Holder within thirty (30) days after the rights represented by this
Warrant shall have been so exercised, and, unless this Warrant has expired, a
new Warrant representing the number of shares of Warrant  Stock, if any, with
respect to which this Warrant has not been exercised shall also be delivered
to the Holder within such time. Notwithstanding the foregoing, however, the
Company shall not be required to deliver any certificates for shares of
Warrant Stock, except in accordance

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with the provisions and subject to the limitations of Paragraph 5 below.

       2.     The Company covenants and agrees that all shares of Warrant Stock
that may be issued upon the exercise of this Warrant will, upon issuance, be
duly authorized and issued, fully paid and nonassessable and free from all
taxes, liens, and charges with respect to the issuance thereof.  The Company
further covenants and agrees that until expiration of this Warrant, the
Company will at all times have authorized, and reserved for the purpose of
issuance upon exercise of this Warrant, a sufficient number of shares of
Common Stock to provide for the exercise of this Warrant.

       3.     The provisions in this Warrant relating to the Warrant Exercise
Price and the number of shares of Warrant Stock to be issued upon exercise of
this Warrant shall be subject to adjustment from time to time as hereinafter
provided.

              (a)    Upon each adjustment of the Warrant Exercise Price, the
       Holder of this Warrant shall thereafter be entitled to purchase, at the
       Warrant Exercise Price resulting from such adjustment, the number of
       shares of Common Stock obtained by multiplying the Warrant Exercise Price
       in effect immediately prior to such adjustment by the number of shares of
       Common Stock purchasable hereto immediately prior to such adjustment and
       dividing the product thereof by the Warrant Exercise Price resulting from
       such adjustment.

              (b)    In case the Company shall at any time subdivide its
       outstanding Common Stock into a greater number of shares or declare a
       dividend payable in Common Stock, the Warrant Exercise Price in effect
       immediately prior to such subdivision shall be proportionately reduced
       and the number of shares of Common Stock purchasable pursuant to this
       Warrant shall be proportionately increased, and conversely, in case the
       Company's outstanding Common Stock shall be combined into a smaller
       number of shares, the Warrant  Exercise Price in effect immediately prior
       to such combination shall be proportionately increased and the number of
       shares of Common Stock purchasable upon the exercise of this Warrant
       shall be proportionately reduced.

              (c)    If any capital reorganization or reclassification of the
       capital stock of the Company, or consolidation or merger of the Company
       with another corporation, or the sale of all or substantially all of its
       assets to another corporation shall be effected in such a way that
       holders of Common Stock shall be entitled to receive stock, securities or
       assets ("Substituted Property") with respect to or in exchange for such
       Common Stock, then, a condition of such reorganization, reclassification,
       consolidation, merger or sale, the Holder shall have the right to
       purchase and receive upon the basis and upon the terms and conditions
       specified in this Warrant, and in lieu of the Common Stock of the Company
       immediately theretofore purchasable and receivable upon the exercise of
       the rights represented hereby, such Substituted Property as would have
       been issued or delivered to the Holder if it had exercised this Warrant
       and had received upon exercise of this Warrant

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       the Common Stock prior to such reorganization, reclassification,
       consolidation, merger, or sale. The Company shall not effect any such
       consolidation, merger, or sale, unless prior to the consummation
       thereof the successor corporation (if other than the Company)
       resulting from such consolidation or merger or the corporation
       purchasing such assets shall assume by written instrument executed
       and mailed to the Holder at the last address of the Holder appearing
       on the books of the Company, the obligation to deliver to the Holder
       such Substituted Property, in accordance with the foregoing
       provisions, the Holder may be entitled to purchase.

              (d)    If the Company takes any other action, or if any other
       event occurs which does not come within the scope of the provisions of
       Paragraphs 3 (b) or 3 (c), but which should result in an adjustment in
       the Warrant Exercise Price and/or the number of shares subject to the
       Warrant in order to fairly protect the purchase rights of the Holder, an
       appropriate adjustment in such purchase rights shall be made by the
       Company.

              (e)    Upon any adjustment of the Warrant Exercise Price or the
       number of shares issuable upon exercise of this Warrant, the Company
       shall have written notice thereof, by first-class mail, postage prepaid,
       addressed to the Holder at the address of the Holder and shown on the
       books of the Company, which notice shall state the Warrant Exercise Price
       resulting from such adjustment and the increase or decrease, if any, in
       the number of shares purchasable at such price upon the exercise of this
       Warrant, setting forth in reasonable detail the method of calculation and
       the facts upon which such calculation is based.

       4.     This Warrant shall not entitle the Holder to any voting rights
or other rights as a shareholder of the Company.

       5.     The Holder, by acceptance hereof, represents and warrants that
(a) it is acquiring this Warrant for its own account for investment purposes
only and not with a view to its resale or distribution and (b) it has no
present intention to resell or otherwise dispose of all or any part of this
Warrant.  Other than pursuant to registration under federal and applicable
state securities laws or exemption from such registration, the availability
of which the Company shall determine in its sole discretion, neither this
Warrant nor any shares of Warrant Stock may be sold, pledged, assigned, or
otherwise disposed of (whether voluntarily or involuntarily).  Company may
condition such sale, pledge, assignment, or other disposition on the receipt
from the party to whom this Warrant is to be so transferred or to whom
Warrant Stock is to be issued or so transferred of any representations and
agreements requested by the Company in order to permit such issuance or
transfer to be made pursuant to exemptions from registration under federal
and applicable state securities laws.  Each certificate representing the
Warrant (or any part thereof) and any shares of Warrant Stock shall bear
appropriate legends setting forth these restrictions on transferability.  The
Holder, by acceptance hereof, agrees to give written notice to the Company
before transferring this Warrant or any shares of Warrant Stock of the
Holder's intention to do so, describing briefly the manner of any proposed
transfer.  Within thirty (30) days after receiving

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such written notice, the Company shall notify the Holder to whether such
transfer may be effected and of the conditions to any such transfer.

       6.   This Warrant shall be transferable only on the books of the
Company by the Holder in person, or by duly authorized attorney, on surrender
of the Warrant, properly assigned.

       7.   Neither this Warrant nor any terms hereof may be changed, waived,
discharged, or terminated orally but only by an instrument in writing signed
by the party against which enforcement of the change, waiver, discharge, or
termination is sought.

       IN WITNESS WHEREOF, the Company has caused this Warrant to be executed on
its behalf by its duly authorized officer on the day and year first above
written.

                                          BIONEBRASKA, INC.

                                          By __________________________________
                                                 Its __________________________

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