Document:

EXHIBIT 4.14

                      Joint Venture Shareholders' Agreement

                                  May 16, 1996

Between:  York Medical Inc.("YM"),  a company incorporated under the laws of the
Province of Ontario,  Canada,  CIMYM Inc., a company incorporated under the laws
of Barbados  ("CIMYM")  and CIMAB S.A.  ("CIMAB") a Cuban  company  incorporated
under the laws of the  Republic  of Cuba,  representing  Centro  de  Inmunologia
Molecular ("CIM").

                                    RECITALS

   Whereas:

o     CIMAB  entered into a licencing  agreement on behalf of CIM,  dated May 4,
      1995 (the "Licencing Agreement");

o     CIMYM has been incorporated to serve as a joint venture company,  owned as
      to 20% of its  common  equity by YM and as to 20% by CIMAB,  to market the
      licenced  products  assigned  to  it  by  YM  pursuant  to  the  Licencing
      Agreement;

o     Certain of the benefits and obligations of the License Agreement have been
      assigned to CIMYM by YM; and,

o     The purpose of this agreement is to set out the  relationship  between the
      parties hereto so that they will proceed on a mutually beneficial basis.

Now,  therefore,  for good and valuable  consideration and the sum of one dollar
(Canadian  funds)  paid by each party to the  other,  receipt of which is hereby
acknowledged.

o     CIMYM shall have an unlimited  number of common shares,  the initial issue
      of which shall be as to 80% to YM and as to 20% to CIMAB.

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o     No issued and  outstanding  shares in the  capital of CIMYM shall be sold,
      transferred  or  otherwise  disposed of to any person  without the written
      consent of each of YM and CIMAB.

o     The issue of any  additional  common  shares in the capital of CIMYM shall
      first be to each of YM and CIMAB in proportion to their shareholdings, and
      thereafter  to any other  person,  but only with the consent of both of YM
      and CIMAB, such consent not to be withheld unreasonably.

o     The board of directors of CIMYM shall consist of nine directors,  three of
      whom shall be  nominees  of YM, two of whom shall be nominees of CIMAB and
      four of whom shall be a resident of Barbados, nominated by YM. The initial
      directors of  CIMYM shall be as set out in Appendix A hereto. The election
      of directors shall take place annually. The board is required to meet once
      per  year in the  Barbados  and at  least  one  other  time  per year at a
      location  to be  agreed  to  among  the  directors  or by  telephone,  and
      otherwise as often as deemed  necessary for the conduct of the business of
      the joint venture in accordance with the Articles of Incorporation and the
      by-laws of CIMYM.  The by laws of CIMYM  shall  provide  that a quorum for
      meetings of the board of  directors  shall be a minimum of four  directors
      and must include one of each of the YM and CIMAB nominees, notice shall be
      a minimum of 30 days prior to any  meeting and  meetings  may be called at
      any time by two directors.

o     CIMYM shall use its best efforts to undertake and perform the terms of the
      assigned  Licence  Agreement.  In all events  CIMYM shall  operate  solely
      through  YM in  CIMYM's  commercialization  of  products  pursuant  to the
      Licence  Agreement,  any  assignment  thereof  and  regarding  any  future
      licencing agreements.

o     All  material  and  out-of-the-ordinary  course of business  contracts  of
      CIMYM,  including  contracts or  agreements  respecting  the  borrowing of
      money,  the issuance of guarantees,  the entering into of  non-arms-length
      agreements,  the  lending of money to any  persons  related to CIMYM,  the
      approval  of the  strategic  marketing  plan,  the  approval of the annual
      budget, the approval for acquisitions,  dispositions and amalgamations and
      the  pledging of property are required to be approved by a majority of the

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      board of directors  including the approval of at least one nominee of each
      of YM and CIMAB.  Such approval may be evidenced either by a resolution of
      the  board of  directors  of  CIMYM or a  written  consent  signed  by the
      required  number of directors.  Any and all other matters  relating to the
      business  and  affairs  of CIMYM  shall be  governed  by the  Articles  of
      Incorporation  and  by-laws or, to the extent not  provided in them,  by a
      majority of the  directors  of CIMYM  evidenced as provided  above.

o     The parties  agree that all of the earnings of CIMYM shall be  distributed
      annually as dividends to the shareholders.  Any variation from this policy
      must be approved by a vote of the  majority  of the  directors,  including
      approval of all of the nominees of YM and CIMAS, respectively.

o     The  auditors  of  CIMYM  shall be KPMG  Peat  Marwick.  CIMYM's  full and
      accurate  records  of  the  net  revenues  shall  be  made  available  for
      inspection by CIMAB.

IN WITNESS  WHEREOF,  THE PARTIES  HERETO HAVE EXECUTED  THIS  AGREEMENT BY DULY
AUTHORIZED OFFICERS OR REPRESENTATIVES THEREOF.

CIMAB S.A.                                           YORK MEDICAL INC.

duly authorized to sign                              duly authorized to sign

                          CIMYM Inc

                          duly authorized to sign

<PAGE>

                                   APPENDIX A

                                Hugh B. Anderson

                                 Diane J. Kalina

                                 Ezra S. Lwowski

                               Colin W. D'A Daniel

                                  Paul W. Haddy

                                 Allan B. Lewis

                                 Philip S. Young

                             Norkis Arteaga Morales

                          Dra: Patricia Sierra BlazquezEXHIBIT 4.15

                                YORK MEDICAL INC.

                      Joint Venture Shareholders' Agreement

                                November 11, 1995

            Between:   York   Medical   Inc.   ("YM"),   a   company
            incorporated  under the laws of the Province of Ontario,
            Canada,  CBQYM INC.,  a company  incorporated  under the
            laws of the Province of Ontario,  Canada ("CBQYM"),  and
            CIMAB S.A., ("CIMAB") a Cuban company incorporated under
            the laws of the Republic of Cuba, representing Centro de
            Bioactivos  Quimicos of the  Universidad  Central de Las
            Villas ("CBQ").

                                    RECITALS

Whereas:

      |X|   CIMAB entered into a licensing  agreement  with YM on behalf of CBQ,
            dated May 3, 1995 (the "Licensing Agreement");

      |X|   CBQYM has been  incorporated  to serve as a joint  venture  company,
            owned as to 80% of its  common  equity by YM and as to 20% by CIMAB,
            to market the licenced products assigned to it by YM pursuant to the
            Licencing Agreement;

      |X|   Certain of the benefits  and  obligations  of the Licence  Agreement
            have been assigned to CBQYM by YM; and

      |X|   The purpose of this agreement is to set out the relationship between
            the  parties  hereto  so  that  they  will  proceed  on  a  mutually
            beneficial basis.

Now therefore, for good and valuable consideration and the sum of one dollar
(Canadian funds) paid by each party to the other, receipt of which is hereby
acknowledged,

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                                      -2-

      |X|   CBQYM shall have an unlimited  number of common shares,  the initial
            issue of which shall be as to 80% to YM and as to 20% to CIMAB.

      |X|   No issued and  outstanding  shares in the  capital of CBQYM shall be
            sold, transferred or otherwise disposed of to any person without the
            written consent of each of YM and CIMAB.

      |X|   The issue of any  additional  common  shares in the capital of CBQYM
            shall  first  be to each of YM and  CIMAB  in  proportion  to  their
            shareholdings,  and thereafter to any other person but only with the
            consent of both of YM and CIMAB,  such  consent  not to be  withheld
            unreasonably.

      |X|   The board of  directors  of CBQYM shall  consist of five  directors,
            three of whom shall be nominees of YM, two of whom shall be nominees
            of CIMAB.  The  initial  directors  of CBQYM  shall be as set out in
            Appendix  A hereto.  The  election  of  directors  shall  take place
            annually ?? board is required to meet once per year,  and  otherwise
            as often as deemed  necessary for the conduct of the business of the
            joint venture in accordance with the Articles of  Incorporation  and
            the  by-laws of CBQYM.  The by-laws of CBQYM  shall  provide  that a
            quorum for meetings of the board of  directors  shall be one of each
            of the YM and CIMAB  nominees,  notice shall be a minimum of 30 days
            prior to any meeting and  meetings  may be called at any time by two
            directors.

      |X|   CBQYM shall use its best efforts to undertake  and perform the terms
            of the assigned Licence Agreement. In all events CBQYM shall operate
            solely through YM in CBQYM's  commercialization of products pursuant
            to the Licence  Agreement,  any assignment thereof and regarding any
            future licencing agreements.

      |X|   All material and out-of-the-ordinary-course of business contracts of
            CBQYM, including contracts or agreements respecting the borrowing of

<PAGE>

                                      -3-

            money,   the  issuance  of   guarantees,   the   entering   into  of
            non-arms-length  agreements,  the  lending  of money to any  persons
            related to CBQYM,  the  payment of  dividends  and the  pledging  of
            property  are required to be approved by four fifths of the board of
            directors.  Such approval may be evidenced either by a resolution of
            the board of directors of CBQYM or a written  consent  signed by the
            required number of directors.  Any and all other matters relating to
            the  business and affairs of CBQYM shall be governed by the Articles
            of Incorporation and by-laws or, to the extent not provided in them,
            by a majority of the directors of CBQYM evidenced as provided above.

      |X|   The auditors of CBQYM shall be KPMG Peat  Marwick.  CBQYM's full and
            accurate  records of the Net Revenues  shall be made  available  for
            inspection by CIMAB.

In witness whereof the parties hereto have executed this Agreement by duly
authorized officers or representatives thereof.

CIMAB S.A.                                             YORK MEDICAL INC.

________________________                               _________________________
duly authorized to sign                                duly authorized to sign

CBQYM INC.

________________________
duly authorized to sign

<PAGE>

                                   APPENDIX A

                         INITIAL DIRECTORS OF CBQYM INC.

                           Dr. Ervello Olazabal Manso

                           Ing. Humberto Martin Perez

                              Ezra Solomon Lwowski

                                Hugh B. Anderson

                          Diane Joan Kalina (President)

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