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                                                                    EXHIBIT 10.9

                           ALTUS PHARMACEUTICALS INC.
                AMENDED AND RESTATED DIRECTOR COMPENSATION POLICY

      The Compensation Committee of the Board of Directors of Altus
Pharmaceuticals Inc. (the "Company") has approved the following policy which
establishes compensation to be paid to non-employee directors of the Company,
effective as of the closing of the Company's initial public offering (the
"Effective Time"), to provide an inducement to obtain and retain the services of
qualified persons to serve as members of the Company's Board of Directors. All
stock option amounts set forth herein shall be subject to automatic adjustment
in the event of any stock split or other recapitalization affecting the
Company's common stock following the Effective Time.

APPLICABLE PERSONS

      This policy shall apply to each director of the Company who is not an
employee of, or compensated consultant to, the Company or any Affiliate, unless
such compensation is received solely for services provided as a member of the
Scientific Advisory Board (each, an "Outside Director"). Affiliate shall mean a
corporation which is a direct or indirect parent or subsidiary of the Company,
as determined pursuant to Section 424 of the Internal Revenue Code of 1986, as
amended.

STOCK OPTION GRANTS

      Annual Grants

      Each Outside Director shall annually be automatically granted a
non-qualified stock option to purchase 8,722 shares of the Company's common
stock under the Company's Amended and Restated 2002 Employee, Director and
Consultant Stock Plan, or any subsequently adopted plan, (the "Stock Plan") at
each annual meeting of the Board of Directors following the Company's annual
meeting of stockholders; provided that if there has been no annual meeting of
stockholders held by the first day of the third fiscal quarter of any year, each
Outside Director will still automatically receive an annual grant of a
non-qualified stock option provided for under this policy on the first day of
the third fiscal quarter of the applicable year; and provided further, that if
an annual meeting of stockholders is subsequently held during the same fiscal
year, no additional annual grant shall be made.

      Initial Grant For Newly Appointed or Elected Directors

      Each new Outside Director on the date of his or her initial appointment or
election to the Board of Directors shall automatically be granted a
non-qualified stock option to purchase 17,444 shares of the Company's common
stock under the Stock Plan.

ANNUAL CASH FEE

      Each Outside Director shall be compensated on an annual basis for
providing services to the Company. Each Outside Director shall receive an annual
fee of $20,000.

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      Cash Payments

      Cash payments to be paid to an Outside Director shall be paid quarterly in
arrears as of the last day of each calendar quarter. If an Outside Director
dies, resigns or is removed during any quarter, he or she shall be entitled to a
cash payment on a pro rata basis through his or her last day of service.

      Initial Fee For Newly Appointed or Elected Directors

      On the last day of the first fiscal quarter following an Outside
Director's first election or appointment to the Board of Directors after the
Effective Time, such Outside Director shall receive his or her quarterly cash
compensation prorated in accordance with the terms of this policy from the
beginning of the calendar quarter in which he or she was initially appointed or
elected and payable as set forth above.

BOARD COMMITTEE COMPENSATION

      Each Outside Director shall also receive an annual fee of $5,000 for each
committee of the Board of Directors on which such individual serves (if not
serving as Chairman of such committee) and shall automatically be granted a
non-qualified stock option under the Stock Plan to purchase 2,181 shares of the
Company's common stock upon election to such committee and an annual grant of a
non-qualified stock option to purchase 1,090 shares of the Company's common
stock each year thereafter. However, the Chairman of each committee, other than
the Audit Committee, shall receive an annual fee of $10,000 and shall
automatically be granted a non-qualified stock option under the Stock Plan to
purchase 4,361 shares of the Company's common stock upon election as Chairman of
such committee and an annual grant of a non-qualified stock option to purchase
2,181 shares of the Company's common stock each year thereafter. The Chairman of
the Audit Committee shall receive an annual fee of $12,500 for services as
Chairman and shall automatically be granted a non-qualified stock option under
the Stock Plan to purchase 4,361 shares of the Company's common stock upon
election of Chairman of such committee and an annual grant of a non-qualified
stock option to purchase 2,181 shares of the Company's common stock each year
thereafter.

      The annual committee service option grants referenced in the paragraph
above shall be automatically granted at each annual meeting of the Board of
Directors following the Company's annual meeting of stockholders; provided that
if there has been no annual meeting of stockholders held by the first day of the
third fiscal quarter of any year, each Outside Director will still automatically
receive annual committee service option grants of non-qualified stock options
provided for under this policy on the first day of the third fiscal quarter of
the applicable year; and provided further, that if an annual meeting of
stockholders is subsequently held during the same fiscal year, no additional
annual committee service option grants shall be made. Notwithstanding the
foregoing, the annual committee grants for fiscal 2006 shall be made on the date
of the adoption of this Amended and Restated Director Compensation Policy to all
Outside Directors who have been elected to a committee on or prior to such date.

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PURCHASE PRICE AND OTHER PROVISIONS APPLICABLE TO ALL STOCK OPTIONS

      All options granted under this policy shall be granted automatically at
the times set forth herein without any further action by the Compensation
Committee and shall (i) vest quarterly over four years commencing on the date of
grant, subject to the Outside Director's continued service on the Board or
applicable committee; provided that all such options shall become exercisable in
full immediately prior to a change in control of the Company, (ii) have an
exercise price equal to the fair market value of the Company's common stock as
determined in the Stock Plan, and (iii) contain the terms and conditions set
forth in the form of non-qualified stock option agreement previously approved by
the Compensation Committee; and provided, further, however, that any options
granted under this policy on or before the date of the adoption of this Amended
and Restated Director Compensation Policy shall vest quarterly over four years
commencing as of January 1, 2006 for any Outside Director who was serving as an
Outside Director as of the Effective Time and for all other Outside Directors as
of the first day of their service to the Board or applicable committee.

EXPENSES

      Upon presentation of documentation of such expenses reasonably
satisfactory to the Company, each Outside Director shall be reimbursed for his
or her reasonable out-of-pocket business expenses incurred in connection with
attending meetings of the Board of Directors, Committees thereof or in
connection with other Board related business.

AMENDMENTS

      The Compensation Committee or the Board of Directors shall review this
Policy from time to time to assess whether any amendments in the type and amount
of compensation provided herein should be adjusted in order to fulfill the
objectives of this Policy.

DATED:  January 9, 2006, as amended and restated on February 2, 2007

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                                                                   Exhibit 10.13

[ALTUS LETTERHEAD]

April 4, 2006

Lauren Sabella
[ADDRESS]

Dear Lauren:

We are pleased you have accepted our offer for the position of Vice President
Commercial Development reporting to me. We offer you a biweekly salary of
$10,192.31, which equates to an annualized salary of $265,000. In addition to
your base salary, you will have an opportunity to earn an annual bonus of up to
35% based on achieving mutually established performance objectives. Our offer to
you also includes Stock Options of 160,000 shares of Altus common stock. Shares
will vest quarterly over a four-year schedule, in accordance with plan
documents, so long as you remain an employee. Your exercise price will be the
common stock price in effect on your first day of employment.

You will also be eligible for a Sign-On Bonus of $100,000 to be paid within 30
days of your hire. Should you voluntarily terminate your employment before the
first anniversary of the Commencement Date, the full amount of the bonus will be
repaid by you to the Company. Should you voluntarily terminate your employment
on or after the first anniversary of the Commencement Date and prior to the
second anniversary of the Commencement Date, one-half of the bonus will be
repaid by you to the Company. In addition, should the Special Incentive Bonus
from your current employer exceed $100,000 and which you are not eligible to
receive if you leave, you will be eligible for up to but not exceeding an
additional $50,000 as a Sign on Bonus with the same terms. We feel this is an
opportunity that will offer you a satisfying position in a challenging growth
environment.

To assist you with your transition to Massachusetts, we will provide you with
corporate housing for one year. If you leave the company within one year you are
responsible to reimburse the company for that expense. After the completion of
one year of service we will review and evaluate our ongoing provision of
corporate housing.

Altus offers a competitive and comprehensive benefits program. All employees are
eligible to participate in the program, which includes group health, dental,
life, and long and short-term disability insurance. You are also eligible to
participate in our matching 401k plan, in accordance with plan guidelines.
Employees also receive generous vacation time, of which you are eligible to
receive five (5) weeks vacation. The company also provides for personal time and
observed as well as floating holidays.

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Lauren Sabella
April 3, 2006
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Your employment is subject to your agreement to Altus's standard employee
non-disclosure and inventions agreement. We have included a copy of the
agreement as an attachment to this offer. Please bring the signed copy with you
on your first day.

The Federal government requires that we verify the employment eligibility of all
new employees. On your first day, please bring two forms of identification
(valid driver's license, original birth certificate, passport, original social
security card, etc) demonstrating you are legally eligible to work in the United
States. This information is required to complete the INS (Immigration and
Naturalization Service) form I-9.

We look forward to you beginning employment with us on Monday, May 1, 2006. Once
you have had an opportunity to review the above information, please let us know
it is acceptable to you by signing below and returning one copy of this letter.

Lauren, everyone who has met you is enthusiastic about your capabilities and
feels confident that Altus will afford you a challenging and rewarding career.
We look forward to having you join us. Please feel free to contact me or Rose
Villandry at (617-299-2813) with any questions or if you need additional
information.

Sincerely,

/s/ Sheldon Berkle
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Sheldon Berkle
President & CEO

I accept the terms of employment offered in this letter.

Signature: /s/ Lauren Sabella
           --------------------------

Date: April 9, 2006

SSN: [SOCIAL SECURITY NUMBER]

Attachments: 1. Non-Disclosure and Inventions Agreement

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