Document:

REGISTRATION RIGHTS AGREEMENT

      This Registration  Rights Agreement (this "Agreement") is made and entered
into as of August 31, 2007, by and among BioForce Nanosciences Holdings, Inc., a
Nevada  corporation  (the  "Company"),  and the purchasers  listed on Schedule I
hereto (the "Purchasers").

      This  Agreement is being entered into pursuant to the Series A Convertible
Preferred Stock Purchase Agreement dated as of the date hereof among the Company
and the Purchasers (the "Purchase Agreement").

      The Company and the Purchasers hereby agree as follows:

      1.    Definitions.

      Capitalized  terms used and not  otherwise  defined  herein shall have the
meanings given such terms in the Purchase Agreement.  As used in this Agreement,
the following terms shall have the following meanings:

            "Advice" shall have the meaning set forth in Section 3(m).

            "Affiliate" means, with respect to any Person, any other Person that
directly or indirectly controls or is controlled by or under common control with
such Person.  For the  purposes of this  definition,  "control,"  when used with
respect to any Person, means the possession, direct or indirect, of the power to
direct or cause the  direction  of the  management  and policies of such Person,
whether  through the ownership of voting  securities,  by contract or otherwise;
and  the  terms  "affiliated,"  "controlling"  and  "controlled"  have  meanings
correlative to the foregoing.

            "Board" shall have the meaning set forth in Section 3(n).

            "Business  Day"  means any day except  Saturday,  Sunday and any day
which shall be a legal  holiday or a day on which  banking  institutions  in the
state  of  Delaware  generally  are  authorized  or  required  by law  or  other
government actions to close.

            "Closing  Date"  means the date of the closing of the  purchase  and
sale of the Preferred Stock and the Warrants pursuant to the Purchase Agreement.

            "Commission" means the Securities and Exchange Commission.

            "Common  Stock" means the Company's  Common Stock,  par value $0.001
per share.

            "Effectiveness  Date" means,  subject to Section  2(b) hereof,  with
respect  to the  Registration  Statement  the  earlier  of (A) the  one  hundred
twentieth  (120th)  day  following  the  Closing  Date  (or  in  the  event  the
Registration  Statement  receives  a "full  review" by the  Commission,  the one
hundred  fiftieth  (150th) day following the Closing Date) or (B) the date which
is within three (3) Business Days after the date on which the Commission informs
the Company (i) that the Commission will not review the  Registration  Statement
or (ii) that the Company may request the  acceleration of the  effectiveness  of

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the Registration Statement and the Company makes such request; provided that, if
the Effectiveness Date falls on a Saturday,  Sunday or any other day which shall
be a legal holiday or a day on which the Commission is authorized or required by
law or other government  actions to close, the  Effectiveness  Date shall be the
following Business Day.

            "Effectiveness  Period"  shall have the meaning set forth in Section
2.

            "Event" shall have the meaning set forth in Section 7(e).

            "Event Date" shall have the meaning set forth in Section 7(e).

            "Exchange  Act"  means  the  Securities  Exchange  Act of  1934,  as
amended.

            "Filing Date" means the  thirtieth  (30th) day following the Closing
Date; provided that, if the Filing Date falls on a Saturday, Sunday or any other
day  which  shall  be a  legal  holiday  or a day on  which  the  Commission  is
authorized or required by law or other  government  actions to close, the Filing
Date shall be the following Business Day.

            "Holder" or "Holders"  means the holder or holders,  as the case may
be, from time to time of Registrable Securities.

            "Indemnified  Party"  shall  have the  meaning  set forth in Section
5(c).

            "Indemnifying  Party"  shall have the  meaning  set forth in Section
5(c).

            "Losses" shall have the meaning set forth in Section 5(a).

            "Person" means an individual or a corporation,  partnership,  trust,
incorporated or  unincorporated  association,  joint venture,  limited liability
company, joint stock company,  government (or an agency or political subdivision
thereof) or other entity of any kind.

            "Preferred Stock" means shares of the Company's Series A Convertible
Preferred  Stock  underlying the Units issued to the Purchasers  pursuant to the
Purchase Agreement.

            "Proceeding"  means  an  action,   claim,  suit,   investigation  or
proceeding   (including,   without  limitation,   an  investigation  or  partial
proceeding, such as a deposition), whether commenced or threatened.

            "Prospectus"  means  the  prospectus  included  in the  Registration
Statement  (including,  without  limitation,  a  prospectus  that  includes  any
information  previously  omitted from a prospectus filed as part of an effective
registration  statement  in  reliance  upon  Rule  430A  promulgated  under  the
Securities Act), as amended or supplemented by any prospectus  supplement,  with
respect  to  the  terms  of  the  offering  of any  portion  of the  Registrable
Securities covered by the Registration  Statement,  and all other amendments and
supplements to the  Prospectus,  including  post-effective  amendments,  and all
material incorporated by reference in such Prospectus.

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            "Registrable  Securities  means the  product of (A) one  hundred ten
percent  (110%) and (B) the shares of Common Stock  issuable upon  conversion of
the Preferred Stock and any dividends  payable thereon plus the shares of Common
Stock issuable upon exercise of the Warrants.

            "Registration  Statement" means the registration  statements and any
additional registration statements contemplated by Section 2, including (in each
case) the Prospectus,  amendments and supplements to such registration statement
or  Prospectus,  including  pre- and  post-effective  amendments,  all  exhibits
thereto,  and all  material  incorporated  by  reference  in  such  registration
statement.

            "Rule 144" means Rule 144 promulgated by the Commission  pursuant to
the  Securities  Act,  as such Rule may be  amended  from  time to time,  or any
similar  rule  or  regulation   hereafter   adopted  by  the  Commission  having
substantially the same effect as such Rule.

            "Rule 158" means Rule 158 promulgated by the Commission  pursuant to
the  Securities  Act,  as such Rule may be  amended  from  time to time,  or any
similar  rule  or  regulation   hereafter   adopted  by  the  Commission  having
substantially the same effect as such Rule.

            "Rule 415" means Rule 415 promulgated by the Commission  pursuant to
the  Securities  Act,  as such Rule may be  amended  from  time to time,  or any
similar  rule  or  regulation   hereafter   adopted  by  the  Commission  having
substantially the same effect as such Rule.

            "Rule 424" means Rule 424 promulgated by the Commission  pursuant to
the  Securities  Act,  as such Rule may be  amended  from  time to time,  or any
similar  rule  or  regulation   hereafter   adopted  by  the  Commission  having
substantially the same effect as such Rule.

            "Securities Act" means the Securities Act of 1933, as amended.

            "Unit"  means the shares of Preferred  Stock and Warrants  issued to
each of the Purchasers pursuant to the Purchase Agreement.

            "Warrants"  means the  warrants  underlying  the  Units to  purchase
shares of  Common  Stock  issued  to the  Purchasers  pursuant  to the  Purchase
Agreement.

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      2.    Resale Registration.

            (a) On or prior to the Filing Date,  the Company  shall  prepare and
file with the  Commission a "resale"  Registration  Statement  providing for the
resale of all Registrable  Securities for an offering to be made on a continuous
basis  pursuant to Rule 415. The  Registration  Statement  shall be on Form SB-2
(except  if the  Company  is not  then  eligible  to  register  for  resale  the
Registrable Securities on Form SB-2, in which case such registration shall be on
another  appropriate form in accordance herewith and with the Securities Act and
the rules promulgated  thereunder).  Such Registration  Statement shall cover to
the  extent  allowable  under  the  Securities  Act  and the  rules  promulgated
thereunder  (including Rule 416), such indeterminate number of additional shares
of Common  Stock  resulting  from  stock  splits,  stock  dividends  or  similar
transactions with respect to the Registrable  Securities.  The Company shall (i)
not  permit  any  securities  other  than  the  Registrable  Securities  and the
securities  listed on  Schedule  II hereto to be  included  in the  Registration
Statement and (ii) use its best efforts to cause the  Registration  Statement to
be declared effective under the Securities Act as promptly as possible after the
filing thereof,  but in any event prior to the  Effectiveness  Date, and to keep
such  Registration  Statement  continuously  effective  under the Securities Act
until  such  date  as is the  earlier  of (x)  the  date  when  all  Registrable
Securities covered by such Registration Statement have been sold or (y) the date
on which the Registrable Securities may be sold without any restriction pursuant
to Rule 144(k) as determined by the counsel to the Company pursuant to a written
opinion  letter,  addressed to the Company's  transfer agent to such effect (the
"Effectiveness  Period").  The Company shall request that the effective  time of
the  Registration  Statement be 4:00 p.m. Eastern Time on the effective date. If
at any time and for any reason, an additional Registration Statement is required
to be filed  because  at such time the actual  number of shares of Common  Stock
into which the Preferred  Stock is convertible  and the Warrants are exercisable
exceeds  the  number of shares of  Registrable  Securities  remaining  under the
Registration Statement, the Company shall have twenty (20) Business Days to file
such  additional  Registration  Statement,  and the  Company  shall use its best
efforts to cause such additional Registration Statement to be declared effective
by the  Commission  as soon as  possible,  but in no event later than sixty (60)
days after filing.

            (b)  Notwithstanding  anything  to the  contrary  set  forth in this
Section 2, in the event the  Commission  does not permit the Company to register
all of the Registrable  Securities in the Registration  Statement because of the
Commission's  application of Rule 415, or for any other reason related  thereto,
the  Company  shall  register  in the  Registration  Statement  such  number  of
Registrable  Securities as is permitted by the  Commission,  provided,  however,
that the number of  Registrable  Securities to be included in such  Registration
Statement or any subsequent  registration  statement  shall be determined in the
following  order: (i) first, the shares of Common Stock issuable upon conversion
of the Preferred Stock shall be registered on a pro rata basis among the holders
of the Preferred  Stock,  and (ii) second,  the shares of Common Stock  issuable
upon exercise of the Warrants  shall be registered on a pro rata basis among the
holders of the Warrants. For purposes of this Section 2(b), "Effectiveness Date"
means with respect to each  subsequent  Registration  Statement  filed  pursuant
hereto,  the earlier of (A) the nintieth (90th) day following the filing date of
such  Registration  Statement  (or  in the  event  such  Registration  Statement
receives a "full review" by the Commission,  the one hundred  twentieth  (120th)
day  following  such  filing  date) or (B) the date  which is  within  three (3)
Business  Days after the date on which the  Commission  informs  the Company (i)
that the Commission will not review such Registration Statement or (ii) that the

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<PAGE>

Company may request the acceleration of the  effectiveness of such  Registration
Statement  and  the  Company  makes  such   request;   provided   that,  if  the
Effectiveness Date falls on a Saturday, Sunday or any other day which shall be a
legal holiday or a day on which the  Commission is authorized or required by law
or other  government  actions  to close,  the  Effectiveness  Date  shall be the
following  Business Day. In the event the Commission does not permit the Company
to register  all of the  Registrable  Securities  in each  initial  Registration
Statement,  the Company  shall use its best efforts to register the  Registrable
Securities,  subject to the terms of this Section 2(b), that were not registered
in the initial Registration  Statement,  as promptly as possible and in a manner
permitted  by the  Commission,  whether  by  filing  a  subsequent  registration
statement  as soon as the  Commission  permits the  Company to do so,  providing
demand registration rights, or otherwise.

      3.    Registration Procedures.

            In connection with the Company's registration obligations hereunder,
the Company shall:

            (a) Prepare and file with the Commission,  on or prior to the Filing
Date,  a  Registration  Statement  on Form SB-2 (or if the  Company  is not then
eligible to register  for resale the  Registrable  Securities  on Form SB-2 such
registration  shall be on another  appropriate  form in accordance  herewith and
with the Securities Act and the rules promulgated thereunder) in accordance with
the plan of distribution as set forth on Exhibit A hereto and in accordance with
applicable law, regulations and Commission policies,  and cause the Registration
Statement to become effective and remain effective as provided herein; provided,
however,  that not less than four (4)  Business  Days prior to the filing of the
Registration  Statement or any related Prospectus or any amendment or supplement
thereto,  the  Company  shall (i)  furnish  to the  Holders,  copies of all such
documents proposed to be filed, which documents will be subject to the review of
such Holders, and (ii) cause its officers and directors, counsel and independent
certified public  accountants to respond to such inquiries as shall be necessary
to conduct a reasonable review of such documents. The Company shall not file the
Registration  Statement or any such  Prospectus or any amendments or supplements
thereto to which the Holders of a majority of the Registrable  Securities  shall
reasonably  object in writing  within three (3) Business  Days of their  receipt
thereof.

            (b) (i)  Prepare  and file  with  the  Commission  such  amendments,
including  post-effective  amendments,  to the Registration  Statement as may be
necessary to keep the Registration  Statement  continuously  effective as to the
applicable  Registrable  Securities for the Effectiveness Period and prepare and
file with the Commission  such  additional  Registration  Statements in order to
register for resale under the Securities Act all of the Registrable  Securities;
(ii) cause the related  Prospectus to be amended or supplemented by any required
Prospectus supplement, and as so supplemented or amended to be filed pursuant to
Rule  424 (or any  similar  provisions  then in  force)  promulgated  under  the
Securities  Act;  (iii)  respond as promptly as possible,  but in no event later
than ten (10) Business Days, to any comments  received from the Commission  with
respect to the Registration  Statement or any amendment  thereto,  except to the
extent that such comments are received  within 30 days  following the completion
of a  fiscal  quarter  or 75 days  following  the end of a  fiscal  year  and as
promptly  as  possible  provide  the  Holders  true and  complete  copies of all
correspondence   from  and  to  the  Commission  relating  to  the  Registration
Statement; (iv) file the final prospectus pursuant to Rule 424 of the Securities

                                      -5-
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Act no later than 9:00 a.m.  Eastern Time on the Business Day following the date
the  Registration  Statement is declared  effective by the  Commission;  and (v)
comply in all material  respects with the  provisions of the  Securities Act and
the Exchange Act with respect to the disposition of all  Registrable  Securities
covered  by the  Registration  Statement  during  the  Effectiveness  Period  in
accordance  with the intended  methods of disposition by the Holders thereof set
forth in the  Registration  Statement as so amended or in such  Prospectus as so
supplemented.

            (c) Notify the  Holders of  Registrable  Securities  as  promptly as
possible  (and, in the case of (i)(A) below,  not less than three (3) days prior
to such filing,  and in the case of (iii)  below,  on the same day of receipt by
the Company of such notice from the  Commission)  and (if  requested by any such
Person)  confirm  such  notice in writing no later  than two (2)  Business  Days
following  the day (i)(A) when a  Prospectus  or any  Prospectus  supplement  or
post-effective  amendment to the  Registration  Statement is filed; (B) when the
Commission  notifies  the  Company  whether  there  will be a  "review"  of such
Registration  Statement and whenever the Commission  comments in writing on such
Registration Statement and (C) with respect to the Registration Statement or any
post-effective  amendment,  when  the  same has  become  effective;  (ii) of any
request by the Commission or any other Federal or state  governmental  authority
for amendments or supplements to the Registration Statement or Prospectus or for
additional  information;  (iii) of the  issuance by the  Commission  of any stop
order suspending the effectiveness of the Registration Statement covering any or
all of the  Registrable  Securities  or the  initiation  or  threatening  of any
Proceedings for that purpose; (iv) if at any time any of the representations and
warranties of the Company contained in any agreement  contemplated hereby ceases
to be true and  correct  in all  material  respects;  (v) of the  receipt by the
Company of any notification  with respect to the suspension of the qualification
or exemption from qualification of any of the Registrable Securities for sale in
any  jurisdiction,  or the  initiation or threatening of any Proceeding for such
purpose;  and (vi) of the  occurrence of any event that makes any statement made
in the  Registration  Statement or  Prospectus or any document  incorporated  or
deemed to be incorporated therein by reference untrue in any material respect or
that requires any revisions to the Registration  Statement,  Prospectus or other
documents so that, in the case of the Registration  Statement or the Prospectus,
as the case may be, it will not contain any untrue  statement of a material fact
or omit to state any material fact required to be stated therein or necessary to
make the statements  therein, in the light of the circumstances under which they
were made, not misleading.

            (d) Use its best  efforts to avoid the  issuance  of, or, if issued,
obtain the withdrawal of, as promptly as possible,  (i) any order suspending the
effectiveness  of the  Registration  Statement  or (ii)  any  suspension  of the
qualification  (or  exemption  from  qualification)  of any  of the  Registrable
Securities for sale in any jurisdiction.

            (e) If  requested  by the  Holders of a majority  in interest of the
Registrable  Securities,  (i) promptly incorporate in a Prospectus supplement or
post-effective  amendment to the Registration  Statement such information as the
Company  reasonably agrees should be included therein and (ii) make all required
filings of such Prospectus  supplement or such post-effective  amendment as soon
as practicable after the Company has received  notification of the matters to be
incorporated in such Prospectus supplement or post-effective amendment.

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<PAGE>

            (f) If  requested  by any Holder,  furnish to such  Holder,  without
charge,  at least one  conformed  copy of each  Registration  Statement and each
amendment thereto,  including financial statements and schedules,  all documents
incorporated or deemed to be incorporated therein by reference, and all exhibits
to the extent requested by such Person (including those previously  furnished or
incorporated by reference)  promptly after the filing of such documents with the
Commission.

            (g) Promptly deliver to each Holder,  without charge, as many copies
of the Prospectus or  Prospectuses  (including each form of prospectus) and each
amendment or  supplement  thereto as such Persons may  reasonably  request;  and
subject to the provisions of Sections 3(m) and 3(n), the Company hereby consents
to the use of such  Prospectus and each amendment or supplement  thereto by each
of the  selling  Holders  in  connection  with  the  offering  and  sale  of the
Registrable   Securities  covered  by  such  Prospectus  and  any  amendment  or
supplement thereto.

            (h) Prior to any public offering of Registrable Securities,  use its
best  efforts to register or qualify or  cooperate  with the selling  Holders in
connection  with the  registration  or  qualification  (or  exemption  from such
registration or qualification) of such Registrable Securities for offer and sale
under the  securities or Blue Sky laws of such  jurisdictions  within the United
States as any Holder  requests in  writing,  to keep each such  registration  or
qualification (or exemption therefrom) effective during the Effectiveness Period
and to do any and all other acts or things  necessary or advisable to enable the
disposition in such  jurisdictions  of the Registrable  Securities  covered by a
Registration  Statement;  provided,  however,  that  the  Company  shall  not be
required to qualify generally to do business in any jurisdiction where it is not
then so qualified or to take any action that would subject it to general service
of process in any such  jurisdiction  where it is not then so subject or subject
the Company to any material tax in any such jurisdiction where it is not then so
subject.

            (i) Cooperate with the Holders to facilitate the timely  preparation
and delivery of  certificates  representing  Registrable  Securities  to be sold
pursuant  to  a  Registration  Statement,  which  certificates,  to  the  extent
permitted by the Purchase  Agreement and applicable federal and state securities
laws, shall be free of all restrictive  legends,  and to enable such Registrable
Securities  to be in such  denominations  and  registered  in such  names as any
Holder may request in connection with any sale of Registrable Securities.

            (j)  Upon  the  occurrence  of any  event  contemplated  by  Section
3(c)(vi), as promptly as possible, prepare a supplement or amendment,  including
a post-effective amendment, to the Registration Statement or a supplement to the
related  Prospectus or any document  incorporated  or deemed to be  incorporated
therein  by  reference,  and file  any  other  required  document  so  that,  as
thereafter  delivered,  neither the  Registration  Statement nor such Prospectus
will contain an untrue  statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements  therein,
in the light of the circumstances under which they were made, not misleading.

            (k) Use  its  best  efforts  to  cause  all  Registrable  Securities
relating to the Registration Statement to continue to be listed or quoted on the
OTC Bulletin Board or any other securities exchange, quotation system or market,
if any,  on which  similar  securities  issued by the Company are then listed or
traded as and when required pursuant to the Purchase Agreement.

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            (l) Comply in all material  respects with all  applicable  rules and
regulations  of the  Commission  and make  generally  available  to its security
holders  all  documents  filed  or  required  to be filed  with the  Commission,
including,  but not limited, to, earning statements satisfying the provisions of
Section  11(a) of the  Securities  Act and Rule 158 not later than 90 days after
the end of any 12-month period if such period is a fiscal year commencing on the
first day of the first fiscal quarter of the Company after the effective date of
the Registration Statement, which statement shall conform to the requirements of
Rule 158.

            (m) The Company may require  each  selling  Holder to furnish to the
Company  information   regarding  such  Holder  and  the  distribution  of  such
Registrable Securities as is required by law to be disclosed in the Registration
Statement,  Prospectus,  or any amendment or supplement thereto, and the Company
may exclude from such registration the Registrable Securities of any such Holder
who  unreasonably  fails to furnish such  information  within a reasonable  time
after receiving such request.

            If the  Registration  Statement  refers  to any  Holder  by  name or
otherwise as the holder of any securities of the Company, then such Holder shall
have the right to require (if such reference to such Holder by name or otherwise
is not required by the Securities Act or any similar federal or applicable state
law then in force) the deletion of the reference to such Holder in any amendment
or supplement to the Registration  Statement filed or prepared subsequent to the
time that such reference ceases to be required.

            Each  Holder  covenants  and  agrees  that  it  will  not  sell  any
Registrable  Securities under the  Registration  Statement until the Company has
electronically   filed  the  Prospectus  as  then  amended  or  supplemented  as
contemplated in Section 3(g) and notice from the Company that such  Registration
Statement and any  post-effective  amendments  thereto have become  effective as
contemplated by Section 3(c).

            Each Holder agrees by its acquisition of such Registrable Securities
that,  upon receipt of a notice from the Company of the  occurrence of any event
of the  kind  described  in  Section  3(c)(ii),  3(c)(iii),  3(c)(iv),  3(c)(v),
3(c)(vi) or 3(n),  such Holder will  forthwith  discontinue  disposition of such
Registrable  Securities  under the  Registration  Statement  until such Holder's
receipt of the copies of the supplemented Prospectus and/or amended Registration
Statement  contemplated  by Section 3(j), or until it is advised in writing (the
"Advice")  by the  Company  that  the use of the  applicable  Prospectus  may be
resumed,  and,  in  either  case,  has  received  copies  of any  additional  or
supplemental  filings  that are  incorporated  or deemed to be  incorporated  by
reference in such Prospectus or Registration Statement.

            (n) If (i) there is material  non-public  information  regarding the
Company which the Company's  Board of Directors (the "Board")  determines not to
be in the  Company's  best  interest  to  disclose  and which the Company is not
otherwise required to disclose, (ii) there is a significant business opportunity
(including,  but not limited to, the acquisition or disposition of assets (other
than in the ordinary  course of business) or any merger,  consolidation,  tender
offer or other  similar  transaction)  available to the Company  which the Board
determines  not to be in the Company's  best interest to disclose,  or (iii) the
Company is  required  to file a  post-effective  amendment  to the  Registration
Statement to incorporate the Company's  quarterly and annual reports and audited
financial  statements  on Forms  10-QSB and  10-KSB,  then the  Company  may (x)

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<PAGE>

postpone  or  suspend  filing of a  registration  statement  for a period not to
exceed thirty (30) consecutive days or (y) postpone or suspend  effectiveness of
a  registration  statement  for a period not to exceed  twenty (20)  consecutive
days;  provided that the Company may not postpone or suspend  effectiveness of a
registration  statement  under this Section 3(n) for more than  forty-five  (45)
days in the aggregate during any three hundred sixty (360) day period; provided,
however,  that no  such  postponement  or  suspension  shall  be  permitted  for
consecutive  twenty  (20) day  periods  arising  out of the  same set of  facts,
circumstances or transactions.

      4.    Registration Expenses.

            All fees and expenses  incident to the  performance of or compliance
with this  Agreement  by the Company,  except as and to the extent  specified in
this  Section 4, shall be borne by the Company  whether or not the  Registration
Statement  is filed or becomes  effective  and  whether  or not any  Registrable
Securities  are  sold  pursuant  to the  Registration  Statement.  The  fees and
expenses  referred  to  in  the  foregoing   sentence  shall  include,   without
limitation, (i) all registration and filing fees (including, without limitation,
fees and expenses  (A) with respect to filings  required to be made with the OTC
Bulletin Board and each other securities exchange or market on which Registrable
Securities  are  required  hereunder  to be listed,  if any (B) with  respect to
filing  fees  required  to be paid to the  National  Association  of  Securities
Dealers,  Inc. and the NASD  Regulation,  Inc. and (C) in compliance  with state
securities  or  Blue  Sky  laws,  (ii)  printing  expenses  (including,  without
limitation,  expenses of printing certificates for Registrable Securities and of
printing  prospectuses  if the  printing of  prospectuses  is  requested  by the
holders of a majority of the Registrable Securities included in the Registration
Statement),  (iii)  messenger,  telephone and delivery  expenses,  (iv) fees and
disbursements  of  counsel  for  the  Company,   (v)  Securities  Act  liability
insurance, if the Company so desires such insurance,  and (vi) fees and expenses
of all other Persons retained by the Company in connection with the consummation
of  the  transactions  contemplated  by  this  Agreement,   including,   without
limitation, the Company's independent public accountants (including the expenses
of any comfort  letters or costs  associated  with the  delivery by  independent
public  accountants of a comfort letter or comfort  letters).  In addition,  the
Company  shall be  responsible  for all of its  internal  expenses  incurred  in
connection  with  the  consummation  of the  transactions  contemplated  by this
Agreement  (including,  without  limitation,  all  salaries  and expenses of its
officers and employees  performing legal or accounting  duties),  the expense of
any annual audit, the fees and expenses  incurred in connection with the listing
of the Registrable  Securities on any securities exchange as required hereunder.
The Company shall not be responsible  for any discounts,  commissions,  transfer
taxes or other similar fees incurred by the Holders in connection  with the sale
of the Registrable Securities.

      5.    Indemnification.

            (a)   Indemnification   by   the   Company.   The   Company   shall,
notwithstanding  any termination of this Agreement,  indemnify and hold harmless
each Holder, the officers, directors, managers, partners, members, shareholders,
agents, brokers,  investment advisors and employees of each of them, each Person
who controls any such Holder (within the meaning of Section 15 of the Securities
Act or Section 20 of the Exchange Act) and the officers,  directors,  agents and
employees of each such  controlling  Person,  to the fullest extent permitted by
applicable  law,  from  and  against  any  and  all  losses,  claims,   damages,
liabilities,  costs  (including,  without  limitation,  costs of preparation and
reasonable  attorneys'  fees) and expenses owed to third parties  (collectively,

                                      -9-
<PAGE>

"Losses") , as incurred,  arising out of or based solely on and to the extent of
or  relating to any  violation  of  securities  laws by the Company or untrue or
alleged  untrue  statement  of a material  fact  contained  in the  Registration
Statement,  any  Prospectus  or any form of  prospectus  or in any  amendment or
supplement  thereto  or in any  preliminary  prospectus,  or  arising  out of or
relating to any omission or alleged  omission of a material  fact required to be
stated therein or necessary to make the  statements  therein (in the case of any
Prospectus  or form of prospectus  or  supplement  thereto,  in the light of the
circumstances  under which they were made) not misleading,  but not in the event
that such untrue  statements or omissions are based upon  information  regarding
such Holder or such other  Indemnified Party furnished in writing to the Company
by such Holder  expressly for use therein.  The Company shall notify the Holders
promptly of the institution,  threat or assertion of any Proceeding of which the
Company  is  aware in  connection  with the  transactions  contemplated  by this
Agreement.  The Company  shall have no  liability  hereunder  for  consequential
damages or for any purported reduction in value. Notwithstanding anything to the
contrary  contained herein,  the Company shall be liable under this Section 5(a)
for only that  amount as does not exceed  the net  proceeds  to the  indemnified
Holder  as a  result  of the sale of  Registrable  Securities  pursuant  to such
Registration Statement.

            (b) Indemnification by Holders. Each Holder shall, severally and not
jointly,  indemnify  and hold  harmless the Company,  its  directors,  officers,
agents and employees,  each Person who controls the Company  (within the meaning
of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the
directors,  officers,  agents and employees of such controlling  Persons, to the
fullest  extent  permitted by applicable  law,  from and against all Losses,  as
incurred,  arising solely out of or based solely upon any untrue  statement of a
material fact contained in the Registration  Statement,  any Prospectus,  or any
form of prospectus, or in any amendment or supplement thereto, or arising solely
out of or based  solely  upon any  omission  of a material  fact  required to be
stated therein or necessary to make the  statements  therein (in the case of any
Prospectus  or form of prospectus  or  supplement  thereto,  in the light of the
circumstances  under which they were made) not  misleading,  to the extent,  but
only to the extent,  that such untrue  statement or omission is contained in any
information so furnished in writing by such Holder or other  Indemnifying  Party
to the Company specifically for inclusion in the Registration  Statement or such
Prospectus.  Notwithstanding  anything to the contrary  contained  herein,  each
Holder  shall be liable under this Section 5(b) for only that amount as does not
exceed the net  proceeds to such  Holder as a result of the sale of  Registrable
Securities pursuant to such Registration Statement.

            (c) Conduct of Indemnification  Proceedings. If any Proceeding shall
be brought or asserted  against any Person  entitled to indemnity  hereunder (an
"Indemnified  Party"),  such Indemnified  Party promptly shall notify the Person
from whom  indemnity  is sought (the  "Indemnifying  Party) in writing,  and the
Indemnifying  Party shall be entitled to assume the defense  thereof,  including
the employment of counsel  reasonably  satisfactory to the Indemnified Party and
the  payment  of all fees and  expenses  incurred  in  connection  with  defense
thereof; provided, that the failure of any Indemnified Party to give such notice
shall not relieve  the  Indemnifying  Party of its  obligations  or  liabilities
pursuant to this  Agreement,  except (and only) to the extent that such  failure
shall have  proximately  and materially  adversely  prejudiced the  Indemnifying
Party.

                                      -10-
<PAGE>

            An Indemnified Party shall have the right to employ separate counsel
in any such Proceeding and to participate in the defense  thereof,  but the fees
and expenses of such counsel shall be at the expense of such  Indemnified  Party
or Parties unless:  (1) the Indemnifying Party has agreed in writing to pay such
fees and expenses;  or (2) the Indemnifying  Party shall have failed promptly to
assume  the  defense  of  such  Proceeding  and  to  employ  counsel  reasonably
satisfactory to such Indemnified Party in any such Proceeding;  or (3) the named
parties to any such Proceeding  (including any impleaded  parties)  include both
such Indemnified  Party and the Indemnifying  Party, and such parties shall have
been  advised by counsel  that a conflict  of interest is likely to exist if the
same counsel were to represent such Indemnified Party and the Indemnifying Party
(in which case, if such  Indemnified  Party notifies the  Indemnifying  Party in
writing  that it  elects  to  employ  separate  counsel  at the  expense  of the
Indemnifying  Party, the  Indemnifying  Party shall not have the right to assume
the defense thereof and such counsel shall be at the expense of the Indemnifying
Party).  The  Indemnifying  Party shall not be liable for any  settlement of any
such Proceeding effected without its written consent, which consent shall not be
unreasonably withheld or delayed. No Indemnifying Party shall, without the prior
written consent of the Indemnified  Party,  effect any settlement of any pending
or threatened  Proceeding in respect of which any  Indemnified  Party is a party
and  indemnity has been sought  hereunder,  unless such  settlement  includes an
unconditional  release of such  Indemnified  Party from all  liability on claims
that are the  subject  matter  of such  Proceeding.  An  Indemnified  Party  who
unreasonably  withholds  its  consent to  settlement  shall not be  entitled  to
further indemnification.

            All fees and expenses of the Indemnified Party (including reasonable
fees and expenses to the extent  incurred in connection  with  investigating  or
preparing  to defend  such  Proceeding  in a manner not  inconsistent  with this
Section) shall be paid to the Indemnified Party, as incurred, within thirty (30)
Business Days of written notice thereof to the Indemnifying Party (regardless of
whether it is ultimately determined that an Indemnified Party is not entitled to
indemnification hereunder;  provided, that the Indemnified Party shall reimburse
all such fees and  expenses  to the extent it is finally  judicially  determined
that such Indemnified Party is not entitled to indemnification hereunder).

            (d) Contribution.  If a claim for indemnification under Section 5(a)
or 5(b) is due but  unavailable to an Indemnified  Party because of a failure or
refusal  of  a  governmental   authority  to  enforce  such  indemnification  in
accordance  with its terms (by reason of public policy or otherwise),  then each
Indemnifying  Party,  in lieu of  indemnifying  such  Indemnified  Party,  shall
contribute to the amount paid or payable by such  Indemnified  Party as a result
of such Losses,  in such  proportion as is  appropriate  to reflect the relative
fault of the  Indemnifying  Party and  Indemnified  Party in connection with the
actions,  statements  or omissions  that  resulted in such Losses as well as any
other relevant equitable considerations. The relative fault of such Indemnifying
Party and  Indemnified  Party shall be  determined  by reference to, among other
things,  whether any action in question,  including any untrue or alleged untrue
statement of a material fact or omission or alleged omission of a material fact,
has been  taken  or made  by,  or  relates  to  information  supplied  by,  such
Indemnifying,  Party or Indemnified  Party,  and the parties'  relative  intent,
knowledge,  access to  information  and  opportunity  to correct or prevent such
action, statement or omission. The amount paid or payable by a party as a result
of any Losses shall be deemed to include,  subject to the  limitations set forth
in Section 5(c), any reasonable  attorneys' or other reasonable fees or expenses
incurred  by such party in  connection  with any  Proceeding  to the extent such
party   would  have  been   indemnified   for  such  fees  or  expenses  if  the
indemnification  provided  for in this  Section was  available  to such party in

                                      -11-
<PAGE>

accordance with its terms. In no event shall any party be required to contribute
an amount under this Section 5(d) in excess of the net proceeds  received by the
indemnified Holder upon sale of such Holder's Registrable Securities pursuant to
the Registration Statement giving rise to such contribution obligation.

            The parties  hereto agree that it would not be just and equitable if
contribution  pursuant  to  this  Section  5(d)  were  determined  by  pro  rata
allocation or by any other method of allocation  that does not take into account
the equitable considerations referred to in the immediately preceding paragraph.
No Person guilty of fraudulent  misrepresentation (within the meaning of Section
11(f) of the Securities Act) shall be entitled to  contribution  from any Person
who was not guilty of such fraudulent misrepresentation to the extent Losses are
attributable thereto.

            The indemnity and contribution  agreements contained in this Section
are in addition to any liability that the  Indemnifying  Parties may have to the
Indemnified Parties pursuant to the law.

      6.    Rule 144.

            As long as any Holder owns Preferred Stock,  Warrants or Registrable
Securities,  the  Company  covenants  to timely  file (or obtain  extensions  in
respect  thereof  and file  within the  applicable  grace  period)  all  reports
required  to be filed by the Company  after the date hereof  pursuant to Section
13(a) or 15(d) of the Exchange Act. As long as any Holder owns Preferred  Stock,
Warrants  or  Registrable  Securities,  if the  Company is not  required to file
reports  pursuant to Section 13(a) or 15(d) of the Exchange Act, it will prepare
and furnish to the Holders and make publicly  available in accordance  with Rule
144(c)  promulgated  under the  Securities  Act annual and  quarterly  financial
statements, together with a discussion and analysis of such financial statements
in form and  substance  substantially  similar to those that would  otherwise be
required  to be included  in reports  required by Section  13(a) or 15(d) of the
Exchange Act, as well as any other  information  required  thereby,  in the time
period that such  filings  would have been  required to have been made under the
Exchange  Act.  The Company  further  covenants  that it will take such  further
action as any Holder may  reasonably  request,  all to the extent  required from
time to time to enable such Person to sell Conversion  Shares and Warrant Shares
without  registration  under the  Securities  Act within the  limitation  of the
exemptions  provided by Rule 144 promulgated under the Securities Act, including
reviewing  any legal  opinions  relating to such sale pursuant to Rule 144. Upon
the request of any Holder,  the Company  shall  deliver to such Holder a written
certification  of a duly  authorized  officer as to whether it has complied with
such requirements.

                                      -12-
<PAGE>

      7.    Miscellaneous.

            (a)  Remedies.  In the  event of a  breach  by the  Company  or by a
Holder,  of any of their obligations  under this Agreement,  such  non-breaching
Holder or the  Company,  as the case may be, in  addition  to being  entitled to
exercise all rights granted by law and under this Agreement,  including recovery
of damages,  will be entitled to specific  performance  of its rights under this
Agreement.  The Company and each Holder agree that  monetary  damages  would not
provide  adequate  compensation for any losses incurred by reason of a breach by
it of any of the provisions of this Agreement and hereby further agrees that, in
the event of any action for specific  performance in respect of such breach,  it
shall waive the defense that a remedy at law would be adequate.

            (b) No Inconsistent  Agreements.  Neither the Company nor any of its
subsidiaries  has, as of the date hereof  entered into and  currently in effect,
nor shall the Company or any of its  subsidiaries,  on or after the date of this
Agreement,  enter into any  agreement  with  respect to its  securities  that is
inconsistent  with the  rights  granted  to the  Holders  in this  Agreement  or
otherwise  conflicts with the provisions hereof.  Except as disclosed in Section
2.1(c) of the  Disclosure  Schedule  prepared in  connection  with the  Purchase
Agreement or Schedule II hereto, neither the Company nor any of its subsidiaries
has  previously  entered into any  agreement  currently  in effect  granting any
registration rights with respect to any of its securities to any Person. Without
limiting the  generality of the  foregoing,  without the written  consent of the
Holders  of a  majority  of the then  outstanding  Registrable  Securities,  the
Company  shall not grant to any  Person  the right to  request  the  Company  to
register  any  securities  of the Company  under the  Securities  Act unless the
rights so granted are subject in all respects to the prior rights in full of the
Holders set forth herein,  and are not otherwise in conflict with the provisions
of this Agreement.

            (c) No  Piggyback on  Registrations.  Neither the Company nor any of
its security holders (other than the Holders in such capacity pursuant hereto or
as disclosed on Schedule II hereto) may include securities of the Company in the
Registration  Statement,  and the Company  shall not after the date hereof enter
into any agreement  providing such right to any of its  securityholders,  unless
the right so granted is subject in all  respects to the prior  rights in full of
the  Holders  set  forth  herein,  and is not  otherwise  in  conflict  with the
provisions of this Agreement.

            (d)  Piggy-Back  Registrations.  If at any time when there is not an
effective  Registration Statement covering (i) Conversion Shares or (ii) Warrant
Shares,  the Company shall  determine to prepare and file with the  Commission a
registration  statement  relating  to an  offering  for its own  account  or the
account of others  under the  Securities  Act of any of its  equity  securities,
other  than on Form S-4 or Form S-8 (each as  promulgated  under the  Securities
Act) or their then equivalents relating to equity securities to be issued solely
in  connection  with  any  acquisition  of any  entity  or  business  or  equity
securities  issuable in connection  with stock option or other employee  benefit
plans, the Company shall send to each Holder of Registrable  Securities  written
notice of such  determination  and, if within  thirty (30) days after receipt of
such notice,  or within such  shorter  period of time as may be specified by the
Company in such  written  notice as may be  necessary  for the Company to comply
with  its  obligations  with  respect  to the  timing  of  the  filing  of  such
registration  statement,  any such Holder  shall so request in  writing,  (which
request shall specify the Registrable  Securities  intended to be disposed of by
the Purchasers),  the Company will cause the  registration  under the Securities

                                      -13-
<PAGE>

Act of all  Registrable  Securities  which the Company has been so  requested to
register by the Holder, to the extent requisite to permit the disposition of the
Registrable  Securities so to be registered,  provided that if at any time after
giving  written  notice of its intention to register any securities and prior to
the effective date of the  registration  statement filed in connection with such
registration,  the Company shall  determine for any reason not to register or to
delay  registration of such securities,  the Company may, at its election,  give
written notice of such determination to such Holder and,  thereupon,  (i) in the
case of a determination not to register,  shall be relieved of its obligation to
register any Registrable  Securities in connection with such  registration  (but
not from its  obligation to pay expenses in  accordance  with Section 4 hereof),
and (ii) in the case of a determination to delay registering, shall be permitted
to delay  registering any Registrable  Securities being  registered  pursuant to
this  Section  7(d) for the same period as the delay in  registering  such other
securities.  The Company shall include in such registration statement all or any
part of such  Registrable  Securities  such Holder  requests  to be  registered;
provided,  however,  that the Company  shall not be  required  to  register  any
Registrable  Securities pursuant to this Section 7(d) that are eligible for sale
pursuant to Rule 144(k) of the  Securities  Act. In the case of an  underwritten
public  offering,  if  the  managing  underwriter(s)  or  underwriter(s)  should
reasonably  object  to the  inclusion  of the  Registrable  Securities  in  such
registration statement, then if the Company after consultation with the managing
underwriter  should reasonably  determine that the inclusion of such Registrable
Securities would materially  adversely affect the offering  contemplated in such
registration statement,  and based on such determination recommends inclusion in
such  registration  statement of fewer or none of the Registrable  Securities of
the  Holders,  then (x) the  number of  Registrable  Securities  of the  Holders
included in such  registration  statement  shall be reduced  pro-rata among such
Holders  (based  upon the  number  of  Registrable  Securities  requested  to be
included  in the  registration),  if the  Company  after  consultation  with the
underwriter(s)  recommends the inclusion of fewer Registrable Securities, or (y)
none of the  Registrable  Securities  of the  Holders  shall be included in such
registration   statement,   if  the   Company   after   consultation   with  the
underwriter(s)  recommends the inclusion of none of such Registrable Securities;
provided, however, that if securities are being offered for the account of other
persons or entities as well as the Company, such reduction shall not represent a
greater fraction of the number of Registrable  securities intended to be offered
by the Holders  than the  fraction of similar  reductions  imposed on such other
persons or entities (other than the Company).

            (e) Failure to File  Registration  Statement and Other  Events.  The
Company and the  Purchasers  agree that the Holders  will suffer  damages if the
Registration  Statement  is not  filed on or prior  to the  Filing  Date and not
declared  effective by the Commission on or prior to the Effectiveness  Date and
maintained in the manner contemplated herein during the Effectiveness  Period or
if certain other events occur. The Company and the Holders further agree that it
would not be feasible to ascertain  the extent of such  damages with  precision.
Accordingly,  if (A) the Registration  Statement is not filed on or prior to the
Filing Date, or (B) the Registration  Statement is not declared effective by the
Commission  on or prior to the  Effectiveness  Date, or (C) the Company fails to
file with the Commission a request for  acceleration in accordance with Rule 461
promulgated  under the Securities Act within three (3) Business Days of the date
that the Company is notified (orally or in writing, whichever is earlier) by the
Commission that a Registration  Statement will not be "reviewed," or not subject
to further review, or (D) the Registration  Statement is filed with and declared
effective  by the  Commission  but  thereafter  ceases to be effective as to all
Registrable  Securities at any time prior to the expiration of the Effectiveness
Period,  without  being  succeeded  immediately  by  a  subsequent  Registration

                                      -14-
<PAGE>

Statement  filed  with and  declared  effective  by the  Commission,  or (E) the
Company has breached  Section  3(n)  hereof,  or (F) trading in the Common Stock
shall be  suspended  or if the Common  Stock is no longer  quoted on or delisted
from the OTC  Bulletin  Board (or other  principal  exchange on which the Common
Stock is traded)  for any reason  for more than three (3)  Business  Days in the
aggregate  (any such failure or breach being  referred to as an "Event," and for
purposes  of clauses  (A) and (B) the date on which such  Event  occurs,  or for
purposes of clause (C) the date on which such three (3)  Business  Day period is
exceeded,  or for purposes of clause (D) after more than  fifteen (15)  Business
Days,  or for  purposes of clause (F) the date on which such three (3)  Business
Day period is exceeded,  being referred to as "Event  Date"),  the Company shall
pay an amount in cash as liquidated  damages to each Holder equal to two percent
(2.0%) of the amount of the Holder's  initial  investment  in the Units for each
calendar  month or  portion  thereof  thereafter  from the Event  Date until the
applicable Event is cured; provided,  however, that in no event shall the amount
of  liquidated  damages  payable at any time and from time to time to any Holder
pursuant to this Section 7(e) exceed an aggregate of twenty percent (20%) of the
amount of the Holder's initial  investment in the Preferred Stock; and provided,
further, that in the event the Commission does not permit all of the Registrable
Securities  to  be  included  in  the  Registration  Statement  because  of  its
application of Rule 415, or for any reason related thereto,  liquidated  damages
payable  pursuant to clause (B) above  shall be payable by the Company  based on
two  percent  (2%) of the  portion of the  Holder's  initial  investment  in the
Preferred  Stock that  corresponds  to the number of such  Holder's  Registrable
Securities  permitted to be registered by the  Commission  pursuant to Rule 415.
Notwithstanding  anything to the contrary in this  paragraph  (e), if (a) any of
the Events  described in clauses (A), (B), (C), (D) or (F) shall have  occurred,
(b) on or prior to the  applicable  Event Date, the Company shall have exercised
its rights under  Section  3(n) hereof and (c) the  postponement  or  suspension
permitted  pursuant  to such  Section  3(n) shall  remain  effective  as of such
applicable Event Date, then the applicable Event Date shall be deemed instead to
occur on the second Business Day following the termination of such  postponement
or  suspension.  Liquidated  damages  payable by the  Company  pursuant  to this
Section  7(d) shall be payable on the first  (1st)  Business  Day of each thirty
(30) day  period  following  the Event  Date.  Notwithstanding  anything  to the
contrary  contained herein, in no event shall any liquidated  damages be payable
with respect to the Warrants or the Warrant Shares.

            (f)  Amendments  and  Waivers.  The  provisions  of this  Agreement,
including  the  provisions  of this  sentence,  may not be amended,  modified or
supplemented,  and waivers or consents to departures from the provisions  hereof
may not be given,  unless the same shall be in writing and signed by the Company
and the Holders of  seventy-five  percent  (75%) of the  Registrable  Securities
outstanding.

                                      -15-
<PAGE>

            (g)  Notices.  Any  notice,   demand,   request,   waiver  or  other
communication  required or permitted to be given  hereunder  shall be in writing
and shall be effective (a) upon hand delivery,  telecopy, e-mail or facsimile at
the address or number  designated  below (if  delivered on a business day during
normal  business  hours  where  such  notice  is to be  received),  or the first
business day following such delivery (if delivered  other than on a business day
during normal  business hours where such notice is to be received) or (b) on the
second  business day following the date of mailing by express  courier  service,
fully  prepaid,  addressed  to such  address,  or upon  actual  receipt  of such
mailing,  whichever  shall first occur.  The addresses  for such  communications
shall be:

                  If to the Company:      BioForce Nanosciences Holdings, Inc.
                                          1615 Golden Aspen Drive, Suite 101
                                          Ames, Iowa, 50010
                                          Attn: Eric Henderson
                                          Tel. No.: (515) 233-8333
                                          Fax No.: (515) 233-8337

                  with copies (which      McCarter & English, LLP
                  shall not constitute    Four Gateway Center
                  notice) to:             100 Mulberry Street
                                          Newark, New Jersey 07102-4056
                                          Attention: Jeffrey A. Baumel, Esq.
                                          Tel. No.: (973) 848-5304
                                          Fax No.: (973) 297-3814

                  If to any  Purchaser:   At the address of such Purchaser set
                                          forth on Schedule I to this Agreement,
                                          with copies to Purchaser's counsel as
                                          set forth on Schedule I, or as
                                          specified in writing by such
                                          Purchaser.

            Any  party  hereto  may from time to time  change  its  address  for
notices by giving at least ten (10) days written notice of such changed  address
to the other party hereto.

            (h) Successors and Assigns. This Agreement shall be binding upon and
inure to the benefit of the parties and their  successors and permitted  assigns
and shall inure to the benefit of each Holder and its  successors  and  assigns.
The Company may not assign this  Agreement  or any of its rights or  obligations
hereunder  without the prior written consent of each Holder.  Each Purchaser may
assign its rights  hereunder in the manner and to the Persons as permitted under
the Purchase Agreement.

            (i)  Assignment of  Registration  Rights.  The rights of each Holder
hereunder,  including  the  right  to  have  the  Company  register  for  resale
Registrable Securities in accordance with the terms of this Agreement,  shall be
automatically assignable by each Holder to any Person of all or a portion of the
Preferred  Stock or the  Registrable  Securities  if: (i) the  Holder  agrees in
writing with the  transferee  or assignee to assign such  rights,  and a copy of
such agreement is furnished to the Company  within a reasonable  time after such
assignment, (ii) the Company is, within a reasonable time after such transfer or
assignment,  furnished  with written  notice of (a) the name and address of such
transferee  or  assignee,  and (b) the  securities  with  respect  to which such
registration  rights are being  transferred  or assigned,  (iii)  following such
transfer  or  assignment  the  further  disposition  of such  securities  by the
transferee or assignees is restricted  under the  Securities  Act and applicable
state  securities  laws,  (iv) at or before the time the  Company  receives  the
written notice  contemplated  by clause (ii) of this Section,  the transferee or
assignee agrees in writing with the Company to be bound by all of the provisions
of this Agreement, and (v) such transfer shall have been made in accordance with

                                      -16-
<PAGE>

the applicable requirements of the Purchase Agreement.  The rights to assignment
shall apply to the Holders (and to subsequent) successors and assigns.

            (j)  Counterparts.  This  Agreement may be executed in any number of
counterparts,  each of which when so executed  shall be deemed to be an original
and, all of which taken together shall constitute one and the same Agreement and
shall  become  effective  when  counterparts  have been signed by each party and
delivered to the other parties hereto, it being understood that all parties need
not sign the same  counterpart.  In the event that any signature is delivered by
facsimile  transmission,  such signature shall create a valid binding obligation
of the party  executing (or on whose behalf such signature is executed) the same
with the same force and effect as if such facsimile  signature were the original
thereof.

            (k) Governing Law; Jurisdiction. This Agreement shall be governed by
and  construed in  accordance  with the internal  laws of the State of Delaware,
without  giving  effect to any of the  conflicts of law  principles  which would
result in the application of the substantive law of another  jurisdiction.  This
Agreement shall not be interpreted or construed with any presumption against the
party  causing this  Agreement to be drafted.  The Company and the Holders agree
that venue for any dispute  arising under this Agreement will lie exclusively in
the state or federal  courts  located in Delaware,  and the parties  irrevocably
waive  any right to raise  forum  non  conveniens  or any  other  argument  that
Delaware  is not the proper  venue.  The  Company  and the  Holders  irrevocably
consent to personal jurisdiction in the state and federal courts of the state of
Delaware.  The Company and the Holders  consent to process  being  served in any
such suit,  action or  proceeding  by delivering a copy thereof to such party at
the  address in effect for  notices to it under this  Agreement  and agrees that
such service shall constitute good and sufficient  service of process and notice
thereof.  Nothing in this  Section 7(k) shall affect or limit any right to serve
process in any other manner permitted by law. The Company and the Holders hereby
agree that the prevailing party in any suit, action or proceeding arising out of
or relating to this  Agreement or the Purchase  Agreement,  shall be entitled to
reimbursement  for  reasonable  legal fees from the  non-prevailing  party.  The
parties hereby waive all rights to a trial by jury.

            (l) Cumulative Remedies. The remedies provided herein are cumulative
and not exclusive of any remedies provided by law.

            (m) Severability. If any term, provision, covenant or restriction of
this  Agreement is held to be invalid,  illegal,  void or  unenforceable  in any
respect, the remainder of the terms, provisions,  covenants and restrictions set
forth  herein  shall  remain  in full  force and  effect  and shall in no way be
affected,  impaired  or  invalidated,  and the  parties  hereto  shall use their
reasonable  efforts to find and employ an alternative  means to achieve the same
or substantially the same result as that  contemplated by such term,  provision,
covenant  or  restriction.  It is  hereby  stipulated  and  declared  to be  the
intention of the parties  that they would have  executed  the  remaining  terms,
provisions, covenants and restrictions without including any of such that may be
hereafter declared invalid, illegal, void or unenforceable.

            (n) Headings.  The headings herein are for convenience  only, do not
constitute a part of this  Agreement  and shall not be deemed to limit or affect
any of the provisions hereof.

                                      -17-
<PAGE>

            (o) Shares  Held by the  Company and its  Affiliates.  Whenever  the
consent  or  approval  of  Holders  of a  specified  percentage  of  Registrable
Securities is required hereunder,  Registrable Securities held by the Company or
its  Affiliates  (other than any Holder or  transferees or successors or assigns
thereof  if such  Holder is deemed  to be an  Affiliate  solely by reason of its
holdings of such  Registrable  Securities)  shall not be counted in  determining
whether  such  consent or  approval  was given by the  Holders of such  required
percentage.

            (p) Independent Nature of Purchasers.  The Company acknowledges that
the obligations of each Purchaser  under the  Transaction  Documents are several
and not joint with the  obligations  of any other  Purchaser,  and no  Purchaser
shall be  responsible in any way for the  performance of the  obligations of any
other Purchaser under the Transaction  Documents.  The Company acknowledges that
the decision of each Purchaser to purchase  Securities  pursuant to the Purchase
Agreement has been made by such Purchaser  independently  of any other Purchaser
and  independently of any information,  materials,  statements or opinions as to
the business, affairs, operations, assets, properties,  liabilities,  results of
operations, condition (financial or otherwise) or prospects of the Company or of
its Subsidiaries  which may have been made or given by any other Purchaser or by
any agent or employee of any other  Purchaser,  and no  Purchaser  or any of its
agents or  employees  shall have any  liability to any  Purchaser  (or any other
person) relating to or arising from any such information,  materials, statements
or opinions.  The Company  acknowledges that nothing contained herein, or in any
Transaction  Document,  and no action taken by any Purchaser  pursuant hereto or
thereto (including,  but not limited to, the (i) inclusion of a Purchaser in the
Registration  Statement  and (ii) review by, and  consent to, such  Registration
Statement by a Purchaser)  shall be deemed to  constitute  the  Purchasers  as a
partnership,  an  association,  a joint venture or any other kind of entity,  or
create a presumption  that the Purchasers are in any way acting in concert or as
a group with respect to such obligations or the transactions contemplated by the
Transaction  Documents.  The Company  acknowledges  that each Purchaser shall be
entitled to  independently  protect and  enforce its rights,  including  without
limitation,  the  rights  arising  out of  this  Agreement  or out of the  other
Transaction Documents,  and it shall not be necessary for any other Purchaser to
be joined as an additional party in any proceeding for such purpose. The Company
acknowledges   that  for  reasons  of   administrative   convenience  only,  the
Transaction  Documents  have been prepared by counsel who does not represent the
Purchasers.  The  Company  acknowledges  that  it has  elected  to  provide  all
Purchasers with the same terms and Transaction  Documents for the convenience of
the  Company  and not  because  it was  required  or  requested  to do so by the
Purchasers.  The Company  acknowledges  that such  procedure with respect to the
Transaction Documents in no way creates a presumption that the Purchasers are in
any  way  acting  in  concert  or as a group  with  respect  to the  Transaction
Documents or the transactions contemplated hereby or thereby.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -18-
<PAGE>

               IN  WITNESS   WHEREOF,   the  parties  hereto  have  caused  this
Registration Rights Agreement to be duly executed by their respective authorized
persons as of the date first indicated above.

                                 BIOFORCE NANOSCIENCES HOLDINGS, INC.

                                 By:_____________________________________
                                    Name: Gregory D. Brown
                                    Title:  Chief Executive Officer

                                 PURCHASER:

                                 By:_____________________________________
                                    Name:
                                    Title:LOCK-UP AGREEMENT

      THIS AGREEMENT (this "Agreement") is dated as of August 31, 2007 by and
among BioForce Nanosciences Holdings, Inc., a Nevada corporation (the
"Company"), and the shareholders of the Company listed on Schedule A attached
hereto (collectively, the "Shareholders").

      WHEREAS, to induce the Company and the investors (the "Investors") to
enter into the Series A Convertible Preferred Stock Purchase Agreement dated as
of the date hereof (the "Purchase Agreement") by and among the Company and the
Investors, the Shareholders have agreed not to sell any shares of the Company's
common stock, $0.001 par value per share, that such Shareholders presently own
or may acquire after the date hereof (the "Common Stock"), except in accordance
with the terms and conditions set forth herein. Capitalized terms used herein
without definition shall have the meanings assigned to such terms in the
Purchase Agreement.

      NOW, THEREFORE, in consideration of the covenants and conditions
hereinafter contained, the parties hereto agree as follows:

      1. Restriction on Transfer; Term. The Shareholders hereby agree with the
Company that the Shareholders will not offer, sell, contract to sell, assign,
transfer, hypothecate, pledge or grant a security interest in, or otherwise
dispose of, or enter into any transaction which is designed to, or might
reasonably be expected to, result in the disposition of (whether by actual
disposition or effective economic disposition due to cash settlement or
otherwise by the Company or any affiliate of the Company or any person in
privity with the Company or any affiliate of the Company), directly or
indirectly, any of the shares of Common Stock from the period commencing on the
Closing Date and expiring on the date that is six (6) months following the
effective date of the initial registration statement filed by the Company with
the Securities and Exchange Commission in accordance with the Registration
Rights Agreement of even date herewith (the "Period").

      2. Ownership. During the Period, the Shareholders shall retain all rights
of ownership in the Common Stock, including, without limitation, voting rights
and the right to receive any dividends, if any, that may be declared in respect
thereof.

      3. Company and Transfer Agent. The Company is hereby authorized to
disclose the existence of this Agreement to its transfer agent. The Company and
its transfer agent are hereby authorized to decline to make any transfer of the
Common Stock if such transfer would constitute a violation or breach of this
Agreement and the Purchase Agreement.

      4. Notices. All notices, demands, consents, requests, instructions and
other communications to be given or delivered or permitted under or by reason of
the provisions of this Agreement or in connection with the transactions
contemplated hereby shall be in writing and shall be deemed to be delivered and
received by the intended recipient as follows: (i) if personally delivered, on

<PAGE>

the business day of such delivery (as evidenced by the receipt of the personal
delivery service), (ii) if mailed certified or registered mail return receipt
requested, four (4) business days after being mailed, (iii) if delivered by
overnight courier (with all charges having been prepaid), on the business day of
such delivery (as evidenced by the receipt of the overnight courier service of
recognized standing), or (iv) if delivered by facsimile transmission, on the
business day of such delivery if sent by 6:00 p.m. in the time zone of the
recipient, or if sent after that time, on the next succeeding business day (as
evidenced by the printed confirmation of delivery generated by the sending
party's telecopier machine). If any notice, demand, consent, request,
instruction or other communication cannot be delivered because of a changed
address of which no notice was given (in accordance with this Section 4), or the
refusal to accept same, the notice, demand, consent, request, instruction or
other communication shall be deemed received on the second business day the
notice is sent (as evidenced by a sworn affidavit of the sender). All such
notices, demands, consents, requests, instructions and other communications will
be sent to the following addresses or facsimile numbers as applicable.

                  If to the Company:      BioForce Nanosciences Holdings, Inc.
                                          1615 Golden Aspen Drive, Suite 101
                                          Ames, Iowa, 50010
                                          Attn: Eric Henderson
                                          Tel. No.: (515) 233-8333
                                          Fax No.: (515) 233-8337

                  with copies (which      McCarter & English, LLP
                  shall not constitute    Four Gateway Center
                  notice) to:             100 Mulberry Street
                                          Newark, New Jersey 07102-4056
                                          Attention: Jeffrey A. Baumel, Esq.
                                          Tel. No.: (973) 848-5304
                                          Fax No.: (973) 297-3814

      If to any of the Shareholders, addressed to such Shareholder at:

or to such other address as any party may specify by notice given to the other
party in accordance with this Section 4.

      5. Amendment. This Agreement may not be modified, amended, altered or
supplemented, except by a written agreement executed by each of the parties
hereto.

      6. Entire Agreement. This Agreement contains the entire understanding and
agreement of the parties relating to the subject matter hereof and supersedes
all prior and/or contemporaneous understandings and agreements of any kind and
nature (whether written or oral) among the parties with respect to such subject
matter, all of which are merged herein.

      7. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware applicable to agreements made
and to be performed in that state, without regard to any of its principles of
conflicts of laws or other laws which would result in the application of the
laws of another jurisdiction. This Agreement shall be construed and interpreted
without regard to any presumption against the party causing this Agreement to be
drafted.

<PAGE>

      8. Waiver of Jury Trial. EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND
IRREVOCABLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY ACTION, SUIT OR
PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS
CONTEMPLATED HEREBY. EACH OF THE PARTIES UNCONDITIONALLY AND IRREVOCABLY
CONSENTS TO THE EXCLUSIVE JURISDICTION OF THE COURTS OF THE STATE OF DELAWARE
AND THE FEDERAL DISTRICT COURT FOR DELAWARE WITH RESPECT TO ANY SUIT, ACTION OR
PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS
CONTEMPLATED HEREBY, AND EACH OF THE PARTIES HEREBY UNCONDITIONALLY AND
IRREVOCABLY WAIVES ANY OBJECTION TO VENUE IN DELAWARE, AND AGREES THAT SERVICE
OF ANY SUMMONS, COMPLAINT, NOTICE OR OTHER PROCESS RELATING TO SUCH SUIT, ACTION
OR OTHER PROCEEDING MAY BE EFFECTED IN THE MANNER PROVIDED IN SECTION 4.

      9. Severability. The parties agree that if any provision of this Agreement
is held to be invalid, illegal or unenforceable in any jurisdiction, that
holding shall be effective only to the extent of such invalidity, illegally or
unenforceability without invalidating or rendering illegal or unenforceable the
remaining provisions hereof, and any such invalidity, illegally or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction. It is the intent of the
parties that this Agreement be fully enforced to the fullest extent permitted by
applicable law.

      10. Binding Effect; Assignment. This Agreement and the rights and
obligations hereunder may not be assigned by any party hereto without the prior
written consent of the other parties hereby. This Agreement shall be binding
upon and shall inure to the benefit of the parties hereto and their respective
successors and permitted assigns.

      11. Headings. The section headings contained in this Agreement (including,
without limitation, section headings and headings in the exhibits and schedules)
are inserted for reference purposes only and shall not affect in any way the
meaning, construction or interpretation of this Agreement. Any reference to the
masculine, feminine, or neuter gender shall be a reference to such other gender
as is appropriate. References to the singular shall include the plural and vice
versa.

      12. Counterparts. This Agreement may be executed in two or more
counterparts, and by the different parties hereto in separate counterparts, each
of which when executed shall be deemed to be an original, and all of which, when
taken together, shall constitute one and the same document. This Agreement shall
become effective when one or more counterparts, taken together, shall have been
executed and delivered by all of the parties. In the event that any signature is
delivered by facsimile transmission, such signature shall create a valid binding
obligation of the party executing (or on whose behalf such signature is
executed) the same with the same force and effect as if such facsimile signature
were the original thereof.

<PAGE>

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

      IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first written above herein.

                                            BIOFORCE NANOSCIENCES HOLDINGS, INC.

                                            By: ________________________________
                                                Name:
                                                Title:

                                            SHAREHOLDER:

                                            By: ________________________________
                                                Name:
                                                Title:

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