Document:

[Letterhead of Milestone Scientific]

                                 March 27, 2001

Mr. Robert Gintel
71 Baldwin Farm South
Greenwich, CT 06831

            Re:   Milestone Scientific Inc. ("Milestone")
                  Purchase of 500,000 shares of Common Stock

Dear Mr. Gintel:

      This will confirm that Milestone has agreed to sell to you, and that you
have agreed to purchase from Milestone, 500,000 shares (the "Shares") of
Milestone's common stock, par value $.001 per share, for the sum of $500,000.
Further, Milestone will use its reasonable best efforts to file with the
Securities and Exchange Commission no later than June 30, 2001, and to cause to
become effective, a registration statement under the Securities Act of 1933, as
amended (the "Securities Act") on Form S-3, and under any applicable state
securities laws, registering the reoffer, resale or other disposition of the
Shares.

      This also will confirm that (i) you are an "accredited investor" within
the meaning of Rule 215 of the Rules and Regulations under the Securities Act,
and (ii) you have acquired the Shares for investment and acknowledge that they
cannot be resold or otherwise disposed of until they are registered under the
Securities Act and any applicable state securities laws or an exemption from
registration is available.

      Since the Shares will not be registered at the time of issuance, the
certificates representing the Shares delivered to you will bear the following
legend:

      THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER
      THE SECURITIES ACT OF 1933. THE SHARES HAVE BEEN ACQUIRED FOR INVESTMENT
      AND MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN
      EFFECTIVE REGISTRATION STATEMENT FOR THESE SHARES UNDER THE SECURITIES ACT
      OF 1933 OR AN OPINION OF THE COMPANY'S COUNSEL THAT REGISTRATION IS NOT
      REQUIRED UNDER THE SAID ACT.

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                                                                          [LOGO]

Mr. Robert Gintel
March 27, 2001

            Please acknowledge your agreement and understanding of the above
provisions by signing and dating a copy of this letter and returning it to us by
facsimile and mail.

                                            Sincerely,

                                            MILESTONE SCIENTIFIC INC.

                                            By: /s/ Leonard Osser
                                               ---------------------------------
                                               Leonard Osser, Chairman and
                                               Chief Executive Officer

ACCEPTED AND AGREED TO
THIS 30th  DAY OF MARCH 2001

/s Robert Gintel
---------------------------
    ROBERT GINTEL

                                       2EXHIBIT 10.20

                                  Leonard Osser
                             220 South Orange Avenue
                          Livingston, New Jersey 07039

                                  April 9, 2000

Milestone Scientific, Inc.
220 South Orange Avenue
Livingston, New Jersey 07039
Attn: Thomas Stuckey, Chief Financial Officer

                   Re: Milestone Scientific Inc. ("Milestone")

Dear Sirs:

      The undersigned hereby provide the following undertaking in connection
with your audit of the financial statements of the above corporation for year
ended December 31, 1999.

      1.    Leonard Osser ("Osser") hereby agrees to open a $200,000 Line of
            Credit for benefit of Milestone. There shall be no facility fee.
            However, Borrowings under the line shall bear interest at the rate
            of 9% per annum, payable at maturity. The Line of Credit shall end
            on December 31, 2000 and all the borrowings then outstanding shall
            be paid by February 1, 2001. Milestone shall draw-down amounts
            against the line by providing Osser with written notice at his home
            address and funds shall be provided within 7 days of notice.

      2.    If Milestone shall provide Osser with notice that it reasonably
            expects to require funds in excess of those available to it under
            the above Line of Credit prior to December 31, 2000, then upon
            receipt of such notice Osser will begin to defer the entire base
            salary to which he is presently entitled under his employment
            agreement. On the commencement of that deferral, his present
            agreement to waive a portion of his salary shall be canceled and
            extinguished and the deferral shall be in the full amount of his
            salary without regard to that prior salary reduction. All amounts
            deferred shall be payable by Milestone on January 3, 2001.

      3.    Osser hereby guarantees the payment in full of all amounts owed to
            Milestone by Dentmate, Inc. (Milestone's Taiwanese distributor) and
            IME Corporation (Milestone's China distributor) whether now owing or
            owing at any time prior to December 31, 2000.

      4.    Osser hereby agrees to defer until January 3, 2001 all prepayments
            owed to him under the 10% Secured Promissory Notes issued in
            February 2000.

      5.    Morse, Zelnick, Rose & Lander, LLP, hereby agrees to defer until
            January 3, 2001, all payment owed to it on $50,000 face amount of
            the 10% secured Promissory Note issued in February, 2000.

                                         Very truly yours,

                                         /s/ Leonard Osser
                                         -------------------------------------
                                                   Leonard Osser

                                         MORSE, ZELNICK, ROSE & LANDER LLP

                                         by: /s/ Stephen A. Zelnick
                                             ---------------------------------
                                                 Stephen A. Zelnick

cc: Grant Thornton - Attn: Chet BorgidaAGREEMENT

            AGREEMENT made as of this 28th day of February, 2001 among MILESTONE
SCIENTIFIC, INC. ("MS"), VESTED MEDIA PARTNERS, INC. ("VMPI") and NEWS USA, INC.
("NU").

            1. NU will, during the term of this agreement, provide the following
advertising and promotional services to MS:

      a.    Prepare, write, print or otherwise publish and provide proof of
            placement of the articles and advertisements detailed below.

      b.    Prepare and cause publication of an aggregate of 60 tabloid pages
            and 60 timed radio segments of articles and advertisements for MS
            and its products and technology. For purposes hereof a tabloid page
            shall be a page containing 8 assorted size news articles per page
            and a timed radio segments shall be at least 60 seconds long. The
            editorial content of the tabloid pages and radio segments shall also
            be distributed to at least 5,000 Websites.

      c.    NU will provide to MS, within 10 days after the end of each calendar
            month, a detailed report as to newspaper, radio station and Website
            placements of the above material. The monthly reports will be
            accompanied by physical clippings from newspapers, air-checks from
            radio stations and other documentation showing the actual placement
            of articles and advertisements. The reports will also detail
            placements by DMA Market, specify the number of placements in that
            month and since the inception of this agreement and the "ad value"
            equivalent".

NU guarantees that the articles and advertisements in (a) and (b) will have at
least 72,000 placements in newspapers and radio stations, as well as parallel
distribution to Websites.

            2. MS hereby agrees to promptly comment on articles and ads
submitted to it and, after its comments are reflected, to promptly approve
finished copy to support NU in its placement activities. Without limitation of
the foregoing, upon receipt of notice from NU that placement is being delayed or
impeded by failure of MS to approve copy, MS will respond to such notice within
48 hours.

            3. In full payment for the services to be rendered by NU hereunder
MS will issue three-year Warrants to purchase 1,171,875 shares of Common Stock,
585,938 to NU and at NU's direction, 585,938 to VMPI. The Warrants will be
exercisable at the following prices

              $1.28 during the first 18 months of the Warrant Term

              $2.25 during the next 9 months of the Warrant Term

              $3.00 during the final 9 months of the Warrant Term

      The Warrants shall be non-transferable and the stock issued on exercise
      thereof shall be restricted stock and bear an appropriate restrictive
      legend. However, Milestone shall, promptly after the date hereof, file a
      Registration Statement with the Securities and Exchange Commission
      allowing the resale of the underlying shares and use its best efforts to
      make such registration effective at the earliest possible date.
      Notwithstanding any registration of the shares, VMPI shall not sell any of
      the underlying shares for a period of one year hereafter and NU shall not
      sell any shares for a period of 4 months hereafter. The lock-up shall be
      waived with respect to 50% of the shares held by each of VMPI and NU, if
      the MS Common Stock trades at prices equal to or greater than $6.25 per
      share for a period of 20 consecutive

<PAGE>

      trading days. The Warrants shall not have any "cashless" exercise
      provision but may be exercised from time to time in the discretion of NU
      and VMPI without limitations as to the number of shares covered in any
      exercise, except that twenty-five percent (25%) of the Warrants held by NU
      and VMPI shall not be exercisable until MS Common Stock trades at a price
      of at least $2.25 for a period of 20 consecutive trading days.

            4. NU shall have the right, in its discretion, during the fourth
month of this agreement, to halt distribution of articles and ads until the
ninth month after execution hereof if the average daily closing price during the
first 10 trading days of that 30 day period does not exceed $2.25, provided that
NU has previously met 1/3 of its total commitment to prepare articles and ads
for client approval. While NU has halted distribution 2/3 of the Warrants
granted hereunder to NU and VMPI shall not be exercisable. NU shall recommence
performance of its obligations whenever the average closing price for a 10-day
period exceeds $2.25. If at the end of the ninth month the stock has not
averaged a $2.25 closing price for a 10 day period NU can either terminate its
obligations hereunder and forfeit 2/3 of the Warrants or resume performance
completing 1/2 of the unperformed obligation in 3 months and the balance in 6
months and retain its Warrants, in either case upon written notice to Milestone
not more than 5 days after the end of such ninth month. If, following a halt in
distribution by NU, NU recommences performance, then the Warrant Exercise Price
shall be re-set to be the greater of the prices set forth in paragraph 3, above
or the average closing price during the 10 days prior to the resumption of
performance by NU.

            5. The term of this agreement shall be 18 months commencing on the
date hereof.

            6. This agreement represents the entire agreement between the
parties and all prior understandings or discussions are merged herein. This
agreement shall be interpreted under the laws of the State of New Jersey and any
disputes among the parties shall be resolved in the courts of that State.

            IN WITNESS WHEREOF the parties have executed this agreement the day
and year first above written.

                                        MILESTONE SCIENTIFIC, INC.

                                        by______________________________________
                                               Leonard Osser, Chairman & CEO

   VESTED MEDIA PARTNERS, INC.

   By:_______________________________
         Kevin F. Sherlock, President

   NEWS USA, INC.

   by:_______________________________
         Rick Smith, CEO

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