Document:

Exhibit 10.3
                             SHARE ESCROW AGREEMENT

     This Agreement is dated as of the [   ] day of [   ], 2005 among Margie
Chassman (the "Guarantor"), [      ] (each a "Purchaser" and collectively
"Purchasers"), and Grushko & Mittman, P.C. (the "Escrow Agent"):

                              W I T N E S S E T H:
                              - - - - - - - - - -

     WHEREAS, Purchasers and Guarantor have or will enter into an agreement
whereunder Purchasers shall purchase on [      ], 2005, in the aggregage,
$[      ] of Stated Value of Class A Preferred Stock (the "Preferred Stock"), of
Novelos Therapeutics, Inc., a Delaware corporation ("Novelos") convertible into
Common Stock of Novelos; and

     WHEREAS, it is beneficial to Guarantor that Purchaser acquire the Preferred
Stock and as an inducement to Purchaser to acquire the Preferred Stock,
Guarantor is assuring that Purchaser will receive a guaranteed return of not
less than twenty percent (20%) per year, compounded annually on the purchase
price of the Preferred Stock, calculated in accordance with the Escrow Demand
annexed hereto and incorporated herein by reference ("Guaranteed Return"); and

     WHEREAS, the Purchasers require the Guarantor to deliver [ ] shares of
restricted, legended common stock together with medallion signature guaranteed
stock powers (collectively "Escrow Shares") to be held in escrow by the Escrow
Agent with such Escrow Shares serving as the source of payment of the Guaranteed
Return, and which will be released by the Escrow Agent in accordance with the
terms and conditions of this Agreement; and

     WHEREAS, the Escrow Agent is willing to serve as escrow agent pursuant to
the terms and conditions of this Agreement;

     NOW THEREFORE, the parties for the mutual promises herein recited and other
good and valuable consideration receipt of which is acknowledged, agree as
follows:

                                    ARTICLE I

                                 INTERPRETATION

     1.1. Definitions. Whenever used in this Agreement, the following terms
shall have the following respective meanings:

          (a) "Agreement" means this Agreement and all amendments made hereto
and thereto by written agreement between the parties;

          (b) "Escrow Share" means the $0.00001 par value Common stock issuable
by Novelos upon conversion of the Preferred Stock.

                                       1

          (c) "End Date" means the first anniversary of the date of this
Agreement, or if not a day the New York Stock Exchange is open for trading, then
the first such trading day thereafter.

          (d) "Escrow Demand" has the meaning set forth above.

          (e) "Guaranteed Return" has the meaning set forth above.

          (f) "Preferred Stock" has the meaning set forth above.

     1.2. Entire Agreement. This Agreement constitutes the entire agreement
between the parties hereto pertaining to the Preferred Stock and Escrow Share
and supersedes all prior agreements, understandings, negotiations and
discussions, whether oral or written, of the parties. There are no warranties,
representations and other agreements made by the parties in connection with the
subject matter hereof except as specifically set forth in this Agreement.

     1.3. Extended Meanings. In this Agreement words importing the singular
number include the plural and vice versa; words importing the masculine gender
include the feminine and neuter genders. The word "person" includes an
individual, body corporate, partnership, trustee or trust or unincorporated
association, executor, administrator or legal representative.

     1.4. Waivers and Amendments. This Agreement may be amended, modified,
superseded, cancelled, renewed or extended, and the terms and conditions hereof
may be waived, only by a written instrument signed by all parties, or, in the
case of a waiver, by the party waiving compliance. Except as expressly stated
herein, no delay on the part of any party in exercising any right, power or
privilege hereunder shall operate as a waiver thereof, nor shall any waiver on
the part of any party of any right, power or privilege hereunder preclude any
other or future exercise of any other right, power or privilege hereunder.

     1.5. Headings. The division of this Agreement into articles, sections,
subsections and paragraphs and the insertion of headings are for convenience of
reference only and shall not affect the construction or interpretation of this
Agreement.

     1.6. Law Governing this Agreement. This Agreement shall be governed by and
construed in accordance with the laws of the State of New York without regard to
principles of conflicts of laws. Subject to Section 4.2, any action brought by
either party against the other concerning the transactions contemplated by this
Agreement shall be brought only in the state courts of New York or in the
federal courts located in the state of New York. All parties and the individuals
executing this Agreement and other agreements on behalf of the parties agree to
submit to the jurisdiction of such courts and waive trial by jury. The
prevailing party (which shall be the party which receives an award most closely
resembling the remedy or action sought) shall be entitled to recover from the
other party its reasonable attorney's fees and costs. In the event that any
provision of this Agreement or any other agreement delivered in connection
herewith is invalid or unenforceable under any applicable statute or rule of
law, then such provision shall be deemed inoperative to the extent that it may
conflict therewith and shall be deemed modified to conform with such statute or
rule of law. Any such provision which may prove invalid or unenforceable under
any law shall not affect the validity or enforceability of any other provision
of any agreement.

                                        2

                                   ARTICLE II

                         DELIVERIES TO THE ESCROW AGENT

     2.1. Delivery of Preferred Stock to Escrow Agent. On or before the date of
this Agreement, the Guarantor shall deliver the Escrow Shares to the Escrow
Agent.

     2.2 Intention to Create Escrow Over Preferred Stock and Escrow Shares. The
Guarantor and Purchaser intend that the Escrow Shares shall be held in escrow by
the Escrow Agent pursuant to this Agreement for their benefit as set forth
herein.

     2.4. Escrow Agent to Deliver Escrow Shares. The Escrow Shares will be held
on behalf of Purchasers in proportion to their relative amounts of Preferred
Stock purchased from Novelos on September 30, 2005. The Escrow Agent shall hold
and release the Escrow Shares only in accordance with the terms and conditions
of this Agreement.

                                  ARTICLE III

                   RELEASE OF PREFERRED STOCK AND ESCROW SHARE

     3.1. Release of Escrow. Subject to the provisions of Section 4.2, the
Escrow Agent shall release the Escrow Shares as follows:

          (a) Upon receipt by the Escrow Agent of an Escrow Demand from a
Purchaser in the form annexed hereto as Exhibit A, together with supporting
calculations, and attachments referred to in the Escrow Demand, the Escrow Agent
will deliver copies of the Escrow Demand and attachments to Guarantor, and not
sooner than two business days nor later than four business days thereafter,
deliver or cause to be delivered to Purchasers the number of Escrow Shares
required to be delivered pursuant to the Escrow Demand. Escrow Agent is
authorized to deliver any share certificate representing the Escrow Shares, to
Novelos transfer agent to be reissued in the names of the Purchasers the
proportionate shares of the Purchasers and as necessary to satisfy an Escrow
Demand. Upon receipt of the reissued Escrow Shares, the Escrow Agent will
deliver the such reissued Escrow Shares to the Purchasers.

          (b) All deliveries to the Guarantor shall be made to the address set
forth in Section 5.2.

          (c) All deliveries to the Purchaser shall be made to the address set
forth in Section 5.2 of this Agreement.

          (d) Purchasers may give Escrow Demands until they no longer own any
Preferred Stock. Any Escrow Shares not required to satisfy Escrow Demands and
still held by Escrow Agent after any Purchasers no longer holds any Preferred
Stock will be expeditiously delivered to Guarantor. Escrow Shares not required
for a Purchaser will be held proportionately for the other Purchasers until no
Purchaser holds Preferred Stock.

                                        3

          (e) Upon receipt by the Escrow Agent of joint written instructions
("Joint Instructions") signed by the Purchaser and the Guarantor, it shall
deliver the Escrow Shares in accordance with the terms of the Joint
Instructions.

          (f) Upon receipt by the Escrow Agent of a final and non-appealable
judgment, order, decree or award of a court of competent jurisdiction (a "Court
Order"), the Escrow Agent shall deliver a notice of receipt thereof to the
Purchaser and the Guarantor (the "Notice of Receipt") and the Escrow Shares in
accordance with the Court Order. Any Court Order shall be accompanied by an
opinion of counsel for the party presenting the Court Order to the Escrow Agent
(which opinion shall be satisfactory to the Escrow Agent) to the effect that the
court issuing the Court Order has competent jurisdiction and that the Court
Order is final and non-appealable.

     3.2. Acknowledgement of Purchaser and Guarantor; Disputes. The Purchaser
and the Guarantor acknowledge that the only terms and conditions upon which the
Escrow Shares are to be released are set forth in Sections 3 and 4 of this
Agreement. The Purchaser and the Guarantor reaffirm their agreement to abide by
the terms and conditions of this Agreement with respect to the release of the
Escrow Shares. Any dispute with respect to the release of the Escrow Shares
shall be resolved pursuant to Section 4.2 or by agreement between the Purchaser
and the Guarantor.

                                   ARTICLE IV

                           CONCERNING THE ESCROW AGENT

     4.1. Duties and Responsibilities of the Escrow Agent. The Escrow Agent's
duties and responsibilities shall be subject to the following terms and
conditions:

          (a) The Guarantor and Purchaser acknowledge and agree that the Escrow
Agent (i) shall not be responsible for or bound by, and shall not be required to
inquire into whether either the Guarantor or Purchaser is entitled to receipt of
the Escrow Shares pursuant to, any other agreement or otherwise; (ii) shall be
obligated only for the performance of such duties as are specifically assumed by
the Escrow Agent pursuant to this Agreement; (iii) may rely on and shall be
protected in acting or refraining from acting upon any written notice,
instruction, instrument, statement, request or document furnished to it
hereunder and believed by the Escrow Agent in good faith to be genuine and to
have been signed or presented by the proper person or party, without being
required to determine the authenticity or correctness of any fact stated therein
or the propriety or validity or the service thereof; (iv) may assume that any
person purporting to give notice or make any statement or execute any document
in connection with the provisions hereof has been duly authorized to do so; (v)
shall not be under any duty to give the property held by Escrow Agent hereunder
any greater degree of care than Escrow Agent gives its own similar property; and
(vi) may consult counsel satisfactory to Escrow Agent, the opinion of such
counsel to be full and complete authorization and protection in respect of any
action taken, suffered or omitted by Escrow Agent hereunder in good faith and in
accordance with the opinion of such counsel.

          (b) The Guarantor and Purchaser acknowledge that the Escrow Agent is
acting solely as a stakeholder at their request and that the Escrow Agent shall
not be liable for any action taken by Escrow Agent in good faith and believed by
Escrow Agent to be authorized or within the rights or powers conferred upon
Escrow Agent by this Agreement, except in the case of gross negligence or
willful misconduct. The Guarantor and Purchaser, jointly and severally, agree to
indemnify and hold

                                       4

harmless the Escrow Agent and any of Escrow Agent's partners, employees, agents
and representatives for any action taken or omitted to be taken by Escrow Agent
or any of them hereunder, including the fees of outside counsel and other costs
and expenses of defending itself against any claim or liability under this
Agreement, except in the case of gross negligence or willful misconduct on
Escrow Agent's part committed in its capacity as Escrow Agent under this
Agreement. The Escrow Agent shall owe a duty only to the Guarantor and Purchaser
under this Agreement and to no other person.

          (c) The Guarantor and Purchaser jointly and severally agree to
reimburse the Escrow Agent for its reasonable out-of-pocket expenses (including
outside counsel fees, to the extent authorized hereunder) incurred in connection
with the performance of its duties and responsibilities hereunder.

          (d) The Escrow Agent may at any time resign as Escrow Agent hereunder
by giving five (5) days prior written notice of resignation to the Guarantor and
the Purchaser. Prior to the effective date of the resignation as specified in
such notice, the Guarantor and Purchaser will issue to the Escrow Agent a Joint
Instruction authorizing delivery of the Escrow Shares to a substitute Escrow
Agent selected by the Guarantor and Purchaser. If no successor Escrow Agent is
named by the Guarantor and Purchaser, the Escrow Agent may apply to a court of
competent jurisdiction in the State of New York for appointment of a successor
Escrow Agent, and to deposit the Escrow Shares with the clerk of any such court.

          (e) The Escrow Agent does not have and will not have any interest in
the Escrow Shares, but is serving only as escrow agent, having only possession
thereof.

          (f) This Agreement sets forth exclusively the duties of the Escrow
Agent with respect to any and all matters pertinent thereto and no implied
duties or obligations shall be read into this Agreement.

          (g) The Escrow Agent shall be permitted to act as counsel for the
Purchaser in any dispute as to the disposition of any Escrow Shares in any other
dispute between the Guarantor and Purchaser, whether or not the Escrow Agent is
then holding any Escrow Shares and continues to act as the Escrow Agent
hereunder.

          (h) The provisions of this Section 4.1 shall survive the resignation
of the Escrow Agent or the termination of this Agreement.

     4.2. Dispute Resolution: Judgments. Resolution of disputes arising under
this Agreement shall be subject to the following terms and conditions:

          (a) If any dispute shall arise with respect to the delivery,
ownership, right of possession or disposition of the Escrow Shares, or if the
Escrow Agent shall in good faith be uncertain as to its duties or rights
hereunder, the Escrow Agent shall be authorized, without liability to anyone, to
(i) refrain from taking any action other than to continue to hold the Escrow
Shares pending receipt of a Joint Instruction from the Guarantor and Purchaser,
or (ii) deposit the Escrow Shares with any court of competent jurisdiction in
the State of New York, in which event the Escrow Agent shall give written notice
thereof to the Guarantor and the Purchaser and shall thereupon be relieved and
discharged from all further obligations pursuant to this Agreement. The Escrow
Agent may, but shall be under no duty to,

                                       5

institute or defend any legal proceedings which relate to the Escrow Shares. The
Escrow Agent shall have the right to retain counsel if it becomes involved in
any disagreement, dispute or litigation on account of this Agreement or
otherwise determines that it is necessary to consult counsel.

          (b) The Escrow Agent is hereby expressly authorized to comply with and
obey any Court Order. In case the Escrow Agent obeys or complies with a Court
Order, the Escrow Agent shall not be liable to the Guarantor and Purchaser or to
any other person, firm, corporation or entity by reason of such compliance.

                                    ARTICLE V

                                 GENERAL MATTERS

     5.1. Termination. This escrow shall terminate upon the release of the
Escrow Shares then being held in escrow by the Escrow Agent or at any time upon
the agreement in writing of the Guarantor and Purchaser.

     5.2. Notices. All notices, requests, demands and other communications
required or permitted hereunder shall be in writing and shall be sent by
telecopy (with the sender's facsimile machine confirming transmission and a copy
of the notice delivered by overnight courier, regular or certified mail) and
shall be deemed to have been duly given (a) one (1) day after being sent, if
sent by 5:00 P.M., New York time on a business day, or (b) the next business day
if sent at any other time

(a) If to the Guarantor, to:

          Margie Chassman
          c/o Andrew J. Levinson, Esq.
          Greenberg & Kahr
          230 Park Avenue, Suite 430
          New York, NY 10169
          Fax: (212) 953-7704

(b) If to the Purchasers, to:

          [                 ]

(c) If to the Escrow Agent, to:

          Grushko & Mittman, P.C.
          Attorneys at Law
          551 Fifth Avenue, Suite 1601
          New York, New York 10176
          Telecopier: (212) 697-3575

or to such other address as any of them shall give to the others by notice made
pursuant to this Section 5.2.

                                       6

     5.3. Assignment; Binding Agreement. Neither this Agreement nor any right or
obligation hereunder shall be assignable by any party without the prior written
consent of the other parties hereto. This Agreement shall enure to the benefit
of and be binding upon the parties hereto and their respective legal
representatives, successors and assigns.

     5.4. Invalidity. In the event that any one or more of the provisions
contained herein, or the application thereof in any circumstance, is held
invalid, illegal, or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every other respect and of
the remaining provisions contained herein shall not be in any way impaired
thereby, it being intended that all of the rights and privileges of the parties
hereto shall be enforceable to the fullest extent permitted by law.

     5.5. Counterparts/Execution. This Agreement may be executed in any number
of counterparts and by different signatories hereto on separate counterparts,
each of which, when so executed, shall be deemed an original, but all such
counterparts shall constitute but one and the same instrument. This Agreement
may be executed by facsimile transmission.

     5.6. Cooperation. Guarantor agrees to cooperate with Purchaser in all
respects necessary in connection with the conversion of the Preferred Stock and
the issuance of Escrow Share in Purchaser's name and the removal of any
restrictive or other legend thereon. Upon release to Purchaser of Escrow Shares,
the Purchaser shall receive all of the right, title and interest to the Escrow
Shares owned by Guarantor, including registration rights.

                      [THIS SPACE INTENTIONALLY LEFT BLANK]

                                       7

     5.7. Agreement. Each of the undersigned states that he has read the
foregoing Note Escrow Agreement and understands and agrees to it.

                                       MARGIE CHASSMAN
                                       the "Guarantor"

                                       ----------------------------------------

                                       the "Purchaser"

                                       By:
                                          -------------------------------------

                                       ESCROW AGENT:

                                       ----------------------------------------
                                       GRUSHKO & MITTMAN, P.C.

     Novelos Therapeutics, Inc. ("Novelos"), by _______________________, its
___________, acknowledges the foregoing Agreement and agrees and undertakes to
facilitate the reissuance of the Escrow Shares in the name of the Purchaser or
other designee requested by Escrow Agent. Novelos acknowledges that the holding
periods of the Escrow Shares for the Purchaser will tack onto the holding period
of the Escrow Shares in the hands of the Guarantor, which holding period
commenced for purposes of Rule 144 under the Securities Act of 1933 on
_______________. Novelos agrees to cooperate with Purchaser in fulfilling the
purposess and intent of this Agreement and not take any action or suffer
inaction inconsistant with Purchaser's lawful rights under this Agreement.

                                       NOVELOS THERAPEUTICS, INC.

                                       By:
                                           -------------------------------------
                                               Name: Harry Palmin, President

                                        8

                               NOTICE OF EXERCISE
                         (QUARTERLY DETERMINATION DATES)

To:  Grushko & Mittman, P.C.
     551 Fifth Avenue, Suite 1601
     New York, NY 10176

     Pursuant to the Escrow Agreement dated [      ], 2005 among Margie Chassman
("Guarantor"), [           ] (each a "Purchaser" and collectively "Purchasers"),
and Grushko & Mittman, P.C. ("Escrow Agent"), the undersigned on behalf of the
undersigned Purchaser hereby exercises the right to send this Notice of Exercise
and receive the number of Escrow Shares described below. All capitalized terms
herein have the definitions attributed to them in the Escrow Agreement.

     1. During the calendar quarter ended ___________, Purchaser sold the
Conversion Shares described oon Schedule A hereto (the "Sold Securities"). Sales
of the Conversion Shares were made in open market arm's length transactions.
Schedule A includes a description of the sales of the Sold Securities including
the amount of Sold Securities, the trade date of each such sale and the net
proceeds received from each such sale.

     2. The amount which would aggregate an annual 20% profit, compounded
annually, on the Sold Securities calculated for the periods during which the
converted Preferred Stock and Sold Securities were actually owned by Purchaser
from the date of the Escrow Agreement until the last day of the above-referenced
calendar quarter, is $_________. This amount is the Guaranteed Return described
in the Escrow Agreement. For purposes of the foregoing calculation, Conversion
Shares received upon conversion of Preferred Stock, if any, that continued to be
owned by the Purchaser on the last day of the relevant calendar quarter ("End
Date") shall be deemed to have been sold on the End Date at the Closing Price,
as hereinafter defined, for the Common Stock on such date ("Attributed Value").
The actual profit (loss) calculated pursuant to Section 1 above, after deducting
the per share purchase price of the Sold Securities and Attributed Value is
$___________. The difference between the actual profit (loss) and the Guaranteed
Return is $____________ ("Deficiency Amount").

     3. Purchaser is hereby exercising its right to receive ___________ Escrow
Shares. The amount of Escrow Shares being purchased hereby is equal to the
Deficiency Amount divided by the closing price of the Common Stock as reported
by Bloomberg, L.P. for the principal trading market upon which the Common Stock
is listed for trading or quotation ("Closing Price"), for the last day of the
calendar quarter referred to above. The Closing Price is $_________.

     4. Guarantor shall not be required to compensate Purchaser for Any
Deficiency Amount except to the extent that Purchaser may exercise its right to
receive the Escrow Shares.

Dated:
       ------------------------------

-------------------------------------

By:
   ----------------------------------

                                       9EXHIBIT 10.10
                                                                  CONFORMED COPY

                                  AMENDMENT TO
                          AGREEMENT AND PLAN OF MERGER

     AMENDMENT, dated October 31, 2005, to AGREEMENT AND PLAN OF MERGER ("Merger
Agreement") made and entered into as of August 22, 2005, by and among CEA
Acquisition Corporation, a Delaware corporation ("Parent"), etrials Acquisition,
Inc., a Delaware corporation and a wholly-owned subsidiary of Parent ("Merger
Sub"), etrials Worldwide, Inc., a Delaware corporation ("Company"), and each of
the persons listed under the caption "Stockholders" on the signature page
hereof, such persons being stockholders of the Company (each a "Stockholder"
and, collectively, the "Stockholders"). Capitalized terms used herein that are
defined in the Merger Agreement shall have the same meanings as used in the
Merger Agreement.

     The parties hereto, being all of the parties to the Merger Agreement,
hereby agree that the Merger Agreement is hereby amended as follows:

     1. A new Section 1.20 is hereby added to the Merger Agreement, to read as
follows:

          1.20 Trigger Condition. In addition to the shares of Parent Common
     Stock constituting the Holdback, there shall be withheld from the shares of
     Parent Common Stock issuable as a result of the Merger and placed in escrow
     with the Escrow Agent pursuant to the Escrow Agreement in the form annexed
     hereto as Exhibit A-1 ("Revised Escrow Agreement"), that number of shares
     of Parent Common Stock (the "Trigger Shares") that, together with the
     Holdback, shall equal 1,400,000 shares of Parent Common Stock. The Trigger
     Shares shall be allocated among the Persons entitled to receive them in the
     same proportions as the shares of Parent Common Stock are allocated among
     them. Notwithstanding any other provision of this Agreement, the Trigger
     Shares and those shares of Parent Common Stock included in the Holdback
     that have not been canceled or paid to Parent as a consequence of the
     indemnity obligations set forth in Article VII (the "Additional Trigger
     Shares") shall be held in escrow pursuant the Revised Escrow Agreement
     until the last day of the first twenty (20) consecutive trading day period
     commencing after the Closing Date during which (a) the volume-weighted
     average price of the Parent Common Stock is equal to or greater than $7.00
     per share and (b) the average daily trading volume of the Parent Common
     Stock is at least 25,000 shares (the "Trigger Release Date"). Upon
     occurrence of the Trigger Release Date, the Trigger Shares and, if the
     Trigger Release Date occurs after the expiration of the Holdback Period,
     the Additional Trigger Shares, shall be released from escrow and delivered
     to the Persons entitled to receive them in the same proportions as
     initially withheld. If the Trigger Release Date occurs prior to expiration
     of the Holdback Period, the Additional Trigger Shares shall be so released
     and delivered upon expiration of the Holdback Period. If

     the Trigger Release Date has not occurred by February 19, 2008, the Trigger
     Shares and the Additional Trigger Shares shall be canceled.

     2. All references in the Merger Agreement to the Escrow Agreement, in the
form of Exhibit A to the Merger Agreement, shall be deemed to be references to
the Revised Escrow Agreement referred to in Section 1.20 of the Merger
Agreement, as amended by this Amendment, in the form annexed hereto as Exhibit
A-1.

     3. All references in the Merger Agreement to "Audited Financial Statements"
shall mean the audited financial statements (including any related notes
thereto) of the Company for the fiscal years ended December 31, 2004 and
December 31, 2003, as included in the Registration Statement on Form S-4 of
Parent relating to the Merger as initially filed with the SEC. All references in
the Merger Agreement to "Unaudited Financial Statements" shall mean the
unaudited financial statements (including any related notes thereto) of the
Company for the six month period ended June 30, 2005 as included in the
Registration Statement on Form S-4 of Parent relating to the Merger as initially
filed with the SEC.

     4. The Merger Agreement, as amended hereby, shall remain in full force and
effect.

                       [Signatures are on following pages]

                                        2

     IN WITNESS WHEREOF, the parties have executed this Amendment to Agreement
and Plan of Merger as of the date first above written.

                                        CEA ACQUISITION CORPORATION

                                        By: /s/ Robert Moreyra
                                            ------------------------------------
                                            Robert Moreyra, Executive Vice
                                               President

                                        etrials ACQUISITION, INC.

                                        By: /s/ Robert Moreyra
                                            ------------------------------------
                                            Robert Moreyra, President

                                        etrials WORLDWIDE, INC.

                                        By: /s/ John Cline
                                            ------------------------------------
                                            John Cline, President

                                        STOCKHOLDERS:

                                        [SEE SEPARATE SIGNATURE PAGES.]

                                        3

           STOCKHOLDER SIGNATURE PAGE TO AMENDMENT TO MERGER AGREEMENT

MINIDOC AB

By: /s/ Per Egeberg/Hans Lindroth
    ---------------------------------
Name: Per Egeberg
Title: CEO

INFOLOGIX (BVI) LIMITED

By: /s/ Janet Raine/Lorraine Wheeler
    ---------------------------------
Name: Janet Raine/Lorraine Wheeler
Title: For and on behalf of EQ
       Secretaries (Jersey) Limited,
       Secretary

NEWLIGHT ASSOCIATES II, LP
By: Newlight Partners II, LP,
    General Partner

By: /s/ Robert M. Brill
    ---------------------------------
Name: Robert M. Brill
Title: General Partner

NEWLIGHT ASSOCIATES II (BVI), LP
By: Newlight Partners II (BVI), LP,
    General Partner

By: /s/ Robert M. Brill
    ---------------------------------
Name: Robert M. Brill
Title: General Partner

NEWLIGHT ASSOCIATES II-E, LP
BY: Newlight Partners II-E, LP,
    General Partner

By: /s/ Robert M. Brill
    ---------------------------------
Name: Robert M. Brill
Title: General Partner

/s/ Peter Coker
-------------------------------------
PETER COKER

                                        4

           STOCKHOLDER SIGNATURE PAGE TO AMENDMENT TO MERGER AGREEMENT

/s/ Peter and Susan H. Coker, JT TEN
-------------------------------------
PETER AND SUSAN H. COKER, JT TEN

DUNLAP INDUSTRIES

By: /s/ Peter L. Coker
    ---------------------------------
Name: Peter L. Coker
Title: Managing Director

/s/ John Cline
-------------------------------------
JOHN CLINE

/s/ James & Susanne M. Clark, JTWROS
-------------------------------------
JAMES W. AND SUSANNE M. CLARK, JT TEN

/s/ Robert Sammis
-------------------------------------
ROBERT SAMMIS

/s/ Fred Nazem
-------------------------------------
FRED NAZEM

E-ZAD PARTNERSHIP LIMITED

By: /s/ Hamid Ansari
    ---------------------------------
Name: Hamid Ansari
Title: General Partner

/s/ Richard J. Piazza
-------------------------------------
RICHARD J. PIAZZA

/s/ Rachael King
-------------------------------------
RACHAEL KING

                                        5

           STOCKHOLDER SIGNATURE PAGE TO AMENDMENT TO MERGER AGREEMENT

/s/ Michael Harte
-------------------------------------
MICHAEL HARTE

                                        6

                                                                     EXHIBIT A-1

                            REVISED ESCROW AGREEMENT

     ESCROW AGREEMENT ("Agreement") dated [Closing Date] among CEA ACQUISITION
CORPORATION, a Delaware corporation ("CEA"), JAMES W. CLARK, JR., AS THE ETRIALS
STOCKHOLDERS' REPRESENTATIVE, being the representative of the former
stockholders of etrials Worldwide, Inc., a Delaware corporation (the
"Representative"), and CONTINENTAL STOCK TRANSFER & TRUST COMPANY, as escrow
agent (the "Escrow Agent").

     CEA, etrials Worldwide, Inc. ("etrials"), certain stockholders of etrials,
and etrials Acquisition, Inc., a Delaware corporation and wholly-owned
subsidiary of CEA ("Merger Subsidiary"), are the parties to an Agreement and
Plan of Merger and Reorganization dated as of August 22, 2005 (the "Merger
Agreement") pursuant to which the Merger Subsidiary has merged with and into
etrials so that etrials has become a wholly-owned subsidiary of CEA. Pursuant to
Section 1.20 of the Merger Agreement, the Trigger Shares and Additional Trigger
Shares are subject to cancellation upon the occurrence of certain events.
Pursuant to Article VII of the Merger Agreement, CEA is to be indemnified in
certain respects by the application of the Holdback Shares (as that term is
defined in Section 1(a), below) including the Additional Trigger Shares. The
parties desire to establish escrow funds with respect to the application of the
Trigger Shares and Additional Trigger Shares in accordance with Section 1.20 of
the Merger Agreement and with respect to the application of the Holdback Shares
(including the Additional Trigger Shares) as collateral security for the
indemnification obligations under Article VII of the Merger Agreement. The
Representative has been designated pursuant to the Merger Agreement to represent
all of the former stockholders of etrials (the "Stockholders") and act on their
behalf for purposes of this Agreement. Capitalized terms used herein which are
not otherwise defined herein shall have the meanings ascribed to them in the
Merger Agreement.

     The parties agree as follows:

     1. (a) Concurrently with the execution hereof, the Escrow Agent, in its
capacity as Exchange Agent pursuant to the Merger Agreement, has withheld (i)
10% of the total number of shares of Parent Common Stock issuable to the
Stockholders pursuant to the Merger Agreement (the "Holdback Shares"), and (ii)
such additional number of shares of Parent Common Stock that, together with the
Holdback Shares, equal 1,400,000 shares of Parent Common Stock (the "Trigger
Shares"), in each instance pro rata in accordance with the number of shares of
Parent Common Stock issuable to each Stockholder. Such shares of Parent Common
Stock are herein referred to in the aggregate as the "Escrow Fund." The Escrow
Agent shall maintain separate accounts for each Stockholder's portion of the
Escrow Fund, designated separately with respect to Holdback Shares and Trigger
Shares.

                                       7

          (b) The Escrow Agent hereby agrees to act as escrow agent and to hold,
safeguard and disburse the Escrow Fund pursuant to the terms and conditions
hereof. It shall treat the Escrow Fund as a trust fund in accordance with the
terms of this Agreement and not as the property of CEA. Its duties hereunder
shall cease upon its distribution of the entire Escrow Fund in accordance with
this Agreement.

          (c) Except as herein provided, the Stockholders shall retain all of
their rights as stockholders of CEA during the period the Escrow Fund is held by
the Escrow Agent (the "Escrow Period"), including, without limitation, the right
to vote their shares of Parent Common Stock included in the Escrow Fund.

          (d) During the Escrow Period, all dividends payable in cash with
respect to the shares of Parent Common Stock included in the Escrow Fund shall
be paid to the Stockholders, but all dividends payable in stock or other
non-cash property ("Non-Cash Dividends") shall be delivered to the Escrow Agent
to hold in accordance with the terms hereof. As used herein, the term "Escrow
Fund" shall be deemed to include the Non-Cash Dividends distributed thereon, if
any.

          (e) During the Escrow Period, no sale, transfer or other disposition
may be made of any or all of the shares of Parent Common Stock in the Escrow
Fund except (i) by gift to a member of a Stockholder's immediate family or to a
trust, the beneficiary of which is a Stockholder or a member of a Stockholder's
immediate family, (ii) by virtue of the laws of descent and distribution upon
death of any Stockholder, or (iii) pursuant to a qualified domestic relations
order; provided, however, that such permissive transfers may be implemented only
upon the respective transferee's written agreement to be bound by the terms and
conditions of this Agreement. During the Escrow Period, the Stockholders shall
not pledge or grant a security interest in the shares of Parent Common Stock
included in the Escrow Fund or grant a security interest in their rights under
this Agreement.

     2. (a) CEA, acting through the members of CEA's Board of Directors who
served on such Board prior to the Closing and who continue to serve on such
Board after the Closing (the "Committee"), who have been appointed by the Board
of Directors to take all necessary actions and make all decisions on behalf of
CEA with respect to its rights to indemnification under the Merger Agreement,
may make a claim for indemnification pursuant to Article VII of the Merger
Agreement ("Indemnity Claim") against the Escrow Fund by giving notice (a
"Notice") to the Representative (with a copy to the Escrow Agent) specifying (i)
the covenant, representation, warranty, agreement, undertaking or obligation
contained in the Merger Agreement which it asserts has been breached or
otherwise entitles CEA to indemnification, (ii) in reasonable detail, the nature
and dollar amount of any indemnity claim CEA may have by reason thereof under
the Merger Agreement ("Indemnity Claim"), and (iii) whether the Indemnity Claim
results from a Third Party Claim against CEA. The Committee also shall deliver
to the Escrow Agent (with a copy to the Representative), concurrently with its
delivery to the Escrow Agent of the Notice, a certification as to the date on
which the Notice was delivered to the Representative.

                                       8

          (b) If the Representative shall give a notice to the Committee (with a
copy to the Escrow Agent) (a "Counter Notice"), within 30 days following the
date of receipt (as specified in the Committee's certification) by the
Representative of a copy of the Notice, disputing whether the Indemnity Claim is
indemnifiable under Article VII of the Merger Agreement, the parties shall
attempt to resolve such dispute by voluntary settlement as provided in paragraph
2(c) below. If no Counter Notice with respect to an Indemnity Claim is received
by the Escrow Agent from the Representative within such 30-day period, the
Indemnity Claim shall be deemed to be an Established Claim (as hereinafter
defined) for purposes of this Agreement.

          (c) If the Representative delivers a Counter Notice to the Escrow
Agent, the Committee and the Representative shall, during the period of 60 days
following the delivery of such Counter Notice or such greater period of time as
the parties may agree to in writing (with a copy to the Escrow Agent), attempt
to resolve the dispute with respect to which the Counter Notice was given. If
the Committee and the Representative shall reach a settlement with respect to
any such dispute, they shall jointly deliver written notice of such settlement
to the Escrow Agent specifying the terms thereof. If the Committee and the
Representative shall be unable to reach a settlement with respect to a dispute,
such dispute shall be resolved by arbitration pursuant to paragraph 2(d) below.

          (d) If the Committee and the Representative cannot resolve a dispute
prior to expiration of the 60-day period referred to in paragraph 2(c) above (or
such longer period as the parties may have agreed to in writing), then such
dispute shall be submitted (and either party may submit such dispute) for
arbitration before a single arbitrator in Orlando, Florida, in accordance with
the commercial arbitration rules of the American Arbitration Association then in
effect. The Committee and the Representative shall attempt to agree upon an
arbitrator; if they shall be unable to agree upon an arbitrator within 10 days
after the date on which it may, under this Agreement, be submitted for
arbitration, then either the Committee or the Representative, upon written
notice to the other, may apply for appointment of such arbitrator by the
American Arbitration Association. Each party shall pay the fees and expenses of
counsel used by it and 50% of the fees and expenses of the arbitrator and of
other expenses of the arbitration. The arbitrator shall render his decision
within 90 days after his appointment and may award costs to any of the parties
if, in his sole opinion reasonably exercised, the claims made by any other party
or parties had no reasonable basis and were arbitrary and capricious. Such
decision and award shall be in writing and shall be final and conclusive on the
parties, and counterpart copies thereof shall be delivered to each of the
parties. Judgment may be obtained on the decision of the arbitrator so rendered
in any court having jurisdiction and may be enforced in accordance with the law
of the State of Florida. If the arbitrator shall fail to render his decision or
award within such 90-day period, either the Committee or the Representative may
apply to any Florida or federal court then having jurisdiction by action,
proceeding or otherwise, as may be proper to determine the matter in dispute
consistently with the provisions of this Agreement. The parties consent to the
exclusive jurisdiction of the Florida courts sitting in the Hillsborough County
for this purpose. The prevailing party (or either party, in the case of

                                       9

a decision or award rendered in part for each party) shall send a copy of the
arbitration decision or of any judgment of the Florida or federal court to the
Escrow Agent.

          (e) As used in this Agreement, "Established Claim" means any (i)
Indemnification Claim deemed established pursuant to the last sentence of
paragraph 2(b) above, (ii) Indemnification Claim resolved in favor of CEA by
settlement of the parties pursuant to paragraph 2(c) above, resulting in a
dollar award to CEA, (iii) Indemnification Claim established by the decision of
an arbitrator pursuant to paragraph 2(d) above, resulting in a dollar award to
CEA, (iv) Third Party Claim which has been sustained by a final determination
(after exhaustion of any appeals) of a court of competent jurisdiction, or (v)
Third Party Claim which the Committee and the Representative have jointly
notified the Escrow Agent has been settled in accordance with the provisions of
the Merger Agreement.

          (f) (i) Promptly after an Indemnity Claim becomes an Established
Claim, the Committee shall deliver a notice to the Escrow Agent directing the
Escrow Agent to pay to CEA, and the Escrow Agent shall pay to CEA or cancel, as
directed by CEA, such number of Holdback Shares that have a value equal to the
aggregate dollar amount of the Established Claim (or, if at such time there
remains in the Escrow Fund Holdback Shares having a value less than the full
amount so payable, the full amount of the Holdback Shares remaining in the
Escrow Fund).

               (ii) Payment of an Established Claim shall be made in shares of
Parent Common Stock, pro rata from the account maintained on behalf of each
Stockholder. In such event, such shares shall be valued at the "Fair Market
Value" (as defined below) and the Escrow Agent shall promptly cause the
appropriate number of shares to be transferred from the Escrow Fund to CEA, or
its order, or, if directed by CEA, cancel, to the extent of the number of
Holdback Shares in the Escrow Fund. The parties hereto (other than the Escrow
Agent) agree that the foregoing right to make payments of Established Claims in
shares of Parent Common Stock may be made notwithstanding any other agreements
restricting or limiting the ability of any Stockholder to sell any shares of CEA
stock or otherwise. As used herein, "Fair Market Value" means the average
reported last sales price for the Parent Common Stock for the ten trading days
ending on the last trading day prior to the day the Established Claim is paid.

     3. On the first Business Day after the eighteen month anniversary of the
Closing Date, upon written instruction from CEA, the Escrow Agent shall
distribute and pay to each Stockholder who has an interest in the Escrow Fund
the Parent Common Stock then in such Stockholder's account in the Escrow Fund
that are Holdback Shares, unless at such time there are any Indemnity Claims
with respect to which Notices have been received but which have not been
resolved pursuant to Section 2 hereof or in respect of which the Escrow Agent
has not been notified of, and received a copy of, a final determination (after
exhaustion of any appeals) by a court of competent jurisdiction, as the case may
be (in either case, "Pending Claims"), and which, if resolved or finally
determined in favor of CEA, would result in a payment to CEA, in which case the
Escrow Agent shall retain, and the total amount of such distributions to such
Stockholder

                                       10

shall be reduced by, the "Pending Claims Reserve" (as hereafter defined).
Thereafter, if any Pending Claim becomes an Established Claim, the Escrow Agent
shall promptly pay to CEA an amount of Holdback Shares in respect thereof
determined in accordance with paragraph 2(f) above, and to the Stockholder the
amount by which the remaining portion of the Holdback Shares in his account in
the Escrow Fund exceeds the then Pending Claims Reserve (determined as set forth
below). If any Pending Claim is resolved against CEA, the Escrow Agent shall
promptly pay to each Stockholder the amount by which the remaining portion of
the Holdback Shares in his account in the Escrow Fund exceeds the then Pending
Claims Reserve. Upon resolution of all Pending Claims, the Escrow Agent shall
pay to such Stockholder the remaining portion of his or her Holdback Shares in
the Escrow Fund. Notwithstanding the foregoing, no Holdback Shares shall be
released by the Escrow Agent to any Stockholder so long as the Trigger Release
Date (as hereinafter defined) has not occurred.

     As used herein, the "Pending Claims Reserve" at any time shall mean an
amount equal to the sum of the aggregate dollar amounts claimed to be due with
respect to all Pending Claims (as shown in the Notices of such Claims).

     4. (a) Notwithstanding anything to the contrary in this Agreement, the
Trigger Shares and those Holdback Shares that have not been paid to CEA or
canceled as a consequence of an Indemnification Claim (the "Additional Trigger
Shares") shall be held in escrow by the Escrow Agent until the last day of the
first twenty (20) consecutive trading day period commencing after the date
hereof during which (i) the volume-weighted average price of the Parent Common
Stock is equal to or greater than $7.00 per share and (ii) the average daily
trading volume of the Parent Common Stock is at least 25,000 shares (the
"Trigger Release Date"), in each case based on information obtained from the
equity page for the Company provided by the Bloomberg reporting service. At any
time after the occurrence of the Trigger Release Date, the Representative may
deliver a notice (a "Trigger Release Notice") to the Escrow Agent, with a copy
to the Committee, stating that the Trigger Release Date has occurred and setting
forth its calculations of the volume-weighted average price of the Parent Common
Stock and the average daily trading volume for the twenty (20) consecutive
trading day period then ended. The Representative also shall deliver to the
Escrow Agent (with a copy to the Committee), concurrently with its delivery to
the Escrow Agent of the Trigger Release Notice, a certification as to the date
on which the Trigger Release Notice was delivered to the Representative.

          (b) If the Committee shall give a notice to the Representative (with a
copy to the Escrow Agent) (a "Trigger Counter Notice"), within 10 days following
the date of receipt (as specified in the Representative's certification) by the
Committee of a copy of the Trigger Release Notice, disputing whether there has
been an occurrence of the Trigger Release Date, the parties shall attempt to
resolve such dispute by voluntary settlement as provided in paragraph 2(c)
above. If no Trigger Counter Notice with respect to a Trigger Release is
received by the Escrow Agent from the Committee within such 10-day period, the
Trigger Release Notice shall be deemed effective for purposes of this Agreement.
If the Committee and the Representative shall reach a settlement with respect to
any such dispute, they shall jointly deliver written notice of such settlement
to

                                       11

the Escrow Agent specifying the terms thereof. If the Committee and the
Representative shall be unable to reach a settlement with respect to a dispute,
such dispute shall be resolved by arbitration pursuant to paragraph 2(d) above.
If, as a result of resolution by the parties or by arbitration, it is determined
that the Trigger Release Date has occurred, the Trigger Release Notice shall be
deemed effective for purposes of this Agreement.

          (c) If the Trigger Release Date occurs prior to the expiration of the
Holdback Period, the Escrow Agent shall release and deliver the Trigger Shares
upon receipt of an effective Trigger Release Notice and shall release and
deliver the Additional Trigger Shares upon the expiration of the Holdback
Period, in each case to the Stockholders having an interest therein. If the
Trigger Release Date occurs after the expiration of the Holdback Period, the
Trigger Shares and Additional Trigger Shares shall be so released and delivered
by the Escrow Agent upon receipt of an effective Trigger Release Notice. If the
Trigger Release Date has not occurred by February 19, 2008, upon written notice
to the Escrow Agent, the Trigger Shares and the Additional Trigger Shares shall
be canceled by the Escrow Agent in its capacity as Transfer Agent for CEA.

     5. The Escrow Agent shall cooperate in all respects with the Committee and
the Representative in the calculation of any amounts determined to be payable to
CEA in accordance with this Agreement.

     6. (a) The Escrow Agent undertakes to perform only such duties as are
expressly set forth herein. It is understood that the Escrow Agent is not a
trustee or fiduciary and is acting hereunder merely in a ministerial capacity.

          (b) The Escrow Agent shall not be liable for any action taken or
omitted by it in good faith and in the exercise of its own best judgment, and
may rely conclusively and shall be protected in acting upon any order, notice,
demand, certificate, opinion or advice of counsel (including counsel chosen by
the Escrow Agent), statement, instrument, report or other paper or document (not
only as to its due execution and the validity and effectiveness of its
provisions, but also as to the truth and acceptability of any information
therein contained) which is believed by the Escrow Agent to be genuine and to be
signed or presented by the proper person or persons. The Escrow Agent shall not
be bound by any notice or demand, or any waiver, modification, termination or
rescission of this Agreement unless evidenced by a writing delivered to the
Escrow Agent signed by the proper party or parties and, if the duties or rights
of the Escrow Agent are affected, unless it shall have given its prior written
consent thereto.

          (c) The Escrow Agent's sole responsibility upon receipt of any notice
requiring any payment to CEA pursuant to the terms of this Agreement or, if such
notice is disputed by the Committee or the Representative, the settlement with
respect to any such dispute, whether by virtue of joint resolution, arbitration
or determination of a court of competent jurisdiction, is to pay to CEA the
amount specified in such notice, and the Escrow Agent shall have no duty to
determine the validity, authenticity or enforceability of any specification or
certification made in such notice.

                                       12

          (d) The Escrow Agent shall not be liable for any action taken by it in
good faith and believed by it to be authorized or within the rights or powers
conferred upon it by this Agreement, and may consult with counsel of its own
choice and shall have full and complete authorization and protection for any
action taken or suffered by it hereunder in good faith and in accordance with
the opinion of such counsel.

          (e) The Escrow Agent may resign at any time and be discharged from its
duties as escrow agent hereunder by its giving the other parties hereto written
notice and such resignation shall become effective as hereinafter provided. Such
resignation shall become effective at such time that the Escrow Agent shall turn
over the Escrow Fund to a successor escrow agent appointed jointly by the
Committee and the Representative. If no new escrow agent is so appointed within
the 60 day period following the giving of such notice of resignation, the Escrow
Agent may deposit the Escrow Fund with any court it reasonably deems
appropriate.

          (f) In the event of a dispute between the parties as to the proper
disposition of the Escrow Fund, the Escrow Agent shall be entitled (but not
required) to deliver the Escrow Fund into the United States District Court for
the Southern District of New York and, upon giving notice to the Committee and
the Representative of such action, shall thereupon be relieved of all further
responsibility and liability.

          (g) The Escrow Agent shall be indemnified and held harmless by CEA
from and against any expenses, including counsel fees and disbursements, or loss
suffered by the Escrow Agent in connection with any action, suit or other
proceeding involving any claim which in any way, directly or indirectly, arises
out of or relates to this Agreement, the services of the Escrow Agent hereunder,
or the Escrow Fund held by it hereunder, other than expenses or losses arising
from the gross negligence or willful misconduct of the Escrow Agent. Promptly
after the receipt by the Escrow Agent of notice of any demand or claim or the
commencement of any action, suit or proceeding, the Escrow Agent shall notify
the other parties hereto in writing. In the event of the receipt of such notice,
the Escrow Agent, in its sole discretion, may commence an action in the nature
of interpleader in an appropriate court to determine ownership or disposition of
the Escrow Fund or it may deposit the Escrow Fund with the clerk of any
appropriate court or it may retain the Escrow Fund pending receipt of a final,
non-appealable order of a court having jurisdiction over all of the parties
hereto directing to whom and under what circumstances the Escrow Fund are to be
disbursed and delivered.

          (h) The Escrow Agent shall be entitled to reasonable compensation from
CEA for all services rendered by it hereunder. The Escrow Agent shall also be
entitled to reimbursement from CEA for all expenses paid or incurred by it in
the administration of its duties hereunder including, but not limited to, all
counsel, advisors' and agents' fees and disbursements and all taxes or other
governmental charges.

          (i) From time to time on and after the date hereof, the Committee and
the Representative shall deliver or cause to be delivered to the Escrow Agent
such further documents and instruments and shall do or cause to be done such
further acts as the Escrow Agent shall reasonably request to carry out more
effectively the provisions and purposes of

                                       13

this Agreement, to evidence compliance herewith or to assure itself that it is
protected in acting hereunder.

          (j) Notwithstanding anything herein to the contrary, the Escrow Agent
shall not be relieved from liability hereunder for its own gross negligence or
its own willful misconduct.

     7. This Agreement expressly sets forth all the duties of the Escrow Agent
with respect to any and all matters pertinent hereto. No implied duties or
obligations shall be read into this Agreement against the Escrow Agent. The
Escrow Agent shall not be bound by the provisions of any agreement among the
parties hereto except this Agreement and shall have no duty to inquire into the
terms and conditions of any agreement made or entered into in connection with
this Agreement, including, without limitation, the Merger Agreement.

     8. This Agreement shall inure to the benefit of and be binding upon the
parties and their respective heirs, successors, assigns and legal
representatives, shall be governed by and construed in accordance with the law
of Delaware applicable to contracts made and to be performed therein except that
issues relating to the rights and obligations of the Escrow Agent shall be
governed by and construed in accordance with the law of New York applicable to
contracts made and to be performed therein. This Agreement cannot be changed or
terminated except by a writing signed by the Committee, the Representative and
the Escrow Agent.

     9. The Committee and the Representative each hereby consents to the
exclusive jurisdiction of the Florida and federal courts sitting in Hillsborough
County with respect to any claim or controversy arising out of this Agreement.
Service of process in any action or proceeding brought against the Committee or
the Representative in respect of any such claim or controversy may be made upon
it by registered mail, postage prepaid, return receipt requested, at the address
specified in Section 10, with a copy delivered by nationally recognized
overnight carrier to Graubard Miller, The Chrysler Building, 405 Lexington
Avenue, New York, N.Y. 10174-1901, Attention: David Alan Miller, Esq.

     10. All notices and other communications under this Agreement shall be in
writing and shall be deemed given if given by hand or delivered by nationally
recognized overnight carrier, or if given by telecopier and confirmed by mail
(registered or certified mail, postage prepaid, return receipt requested), to
the respective parties as follows:

               A.   If to the Committee, to it at
                    c/o CEA Acquisition Corporation
                    101 East Kennedy Boulevard, Suite 3300
                    Tampa, Florida 33602
                    Attention: Robert Moreyra
                    Telecopier No.: 813-314-9504

                    with a copy to:

                                       14

                    Graubard Miller
                    The Chrysler Building
                    405 Lexington Avenue
                    New York, New York 10174-1901
                    Attention: David Alan Miller, Esq.
                    Telecopier No.: 212-818-8881

               B.   If to the Representative, to him at

                    James W. Clark, Jr.
                    c/o etrials Worldwide, Inc.
                    4000 Aerial Center Parkway
                    Morrisville, North Carolina 27560
                    Telecopier No.: 919-653-3621

                    with a copy to:

                    Daniels, Daniels & Verdonik, P.A.
                    Suite 200, Generation Plaza
                    1822 N.C. Highway 54 East
                    P.O. Drawer 122
                    Research Triangle Park, N.C. 22709-2218
                    Attention: James F. Verdonik
                    Telecopier No.: 919 544 5920

               C.   If to the Escrow Agent, to it at:

                    Continental Stock Transfer & Trust Company
                    2 Broadway
                    New York, New York 10004
                    Attention: Steven G. Nelson
                    Telecopier No.: 212-509-5150

or to such other person or address as any of the parties hereto shall specify by
notice in writing to all the other parties hereto.

     11. (a) If this Agreement requires a party to deliver any notice or other
document, and such party refuses to do so, the matter shall be submitted to
arbitration pursuant to paragraph 3(d) of this Agreement.

          (b) All notices delivered to the Escrow Agent shall refer to the
provision of this Agreement under which such notice is being delivered and, if
applicable, shall clearly specify the aggregate dollar amount due and payable to
CEA.

                                       15

          (c) This Agreement may be executed in any number of counterparts, each
of which shall be deemed to be an original instrument and all of which together
shall constitute a single agreement.

          IN WITNESS WHEREOF, each of the parties hereto has duly executed this
Agreement on the date first above written.

                                             CEA ACQUISITION CORPORATION

                                             By:
                                                 -------------------------------
                                             Name:
                                             Title:

                                             THE REPRESENTATIVE

                                             -----------------------------------
                                             Name: James W. Clark, Jr.

                                             ESCROW AGENT

                                             CONTINENTAL STOCK TRANSFER &
                                                TRUST COMPANY

                                             By:
                                                 -------------------------------
                                             Name: Steven G. Nelson
                                             Title: Chairman

                                       16

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