Document:

<PAGE>
                                                                    EXHIBIT 4.17

                                                                      $3,000,000

AS OF APRIL 14, 2003, (THE "AMENDMENT DATE"), THIS SUBORDINATED PROMISSORY NOTE
AMENDS AND RESTATES IN ITS ENTIRETY CERTAIN SUBORDINATED PROMISSORY NOTES DATED
OCTOBER 1, 2001, MAY 3, 2002 AND OCTOBER 28, 2002 BETWEEN NEMATRON CORPORATION
AND NORTH COAST TECHNOLOGY INVESTORS L.P. (THE "FORMER NOTE"). THE FORMER NOTES
SHALL BE OF NO FORCE OR EFFECT AS OF APRIL 14, 2003.

THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED
(THE "SECURITIES ACT"), OR UNDER ANY OTHER SECURITIES LAWS. IT MAY NOT BE SOLD
OR OFFERED FOR SALE IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO
THIS NOTE UNDER THE SECURITIES ACT OR AN OPINION OF COUNSEL REASONABLY
SATISFACTORY TO NEMATRON THAT SUCH REGISTRATION IS NOT REQUIRED.

                          SUBORDINATED PROMISSORY NOTE

$3,000,000                                                        APRIL 14, 2003

Ann Arbor, Michigan

      For value received, NEMATRON CORPORATION, a Michigan corporation (the
"Company"), promises to pay to the order of NORTH COAST TECHNOLOGY INVESTORS,
L.P., at 206 S. Fifth Avenue, Ann Arbor, Michigan 48104 ("North Coast"), or its
permitted assigns, the principal sum of THREE MILLION DOLLARS ($3,000,000), or
so much thereof as is advanced hereunder from time to time. Interest shall be
payable on the unpaid principal balance of this Note, computed on the basis of
actual number of days elapsed, from the date hereof at the rate of FOURTEEN
PERCENT (14%) per annum. The principal and interest on this Note shall be paid
in lawful money of the United States UPON DEMAND by the holder hereof. All
payments received shall be applied first to accrued interest and the balance
shall be applied to principal.

      North Coast shall advance to the Company up to the principal amount set
forth above, from time to time upon the request of the Company, provided that
each and every advance shall be made or declined in the sole discretion of North
Coast, and North Coast shall have no liability to the Company for its failure or
refusal to make any advance.

      The Company and North Coast acknowledge that all amounts due and payable
are hereby expressly subordinated in right of payment to the prior payment in
full of the indebtedness referenced in the Subordination Agreement, dated March
23, 2001, between North Coast and LaSalle Business Credit, Inc.

      Amounts borrowed under this Note may be prepaid at any time and from time
to time, in whole or in part, without penalty or premium, upon at least five (5)
business days prior written notice from the Company to North Coast, unless,
prior to such repayment, North Coast provides notice to the Company of its
intent to exercise its conversion rights provided in the sixth or seventh
<PAGE>
paragraphs of this Note. North Coast's notice of intent to exercise its
conversion rights shall be effective notwithstanding the Company's notice of
intent to repay. This Note shall be payable in cash or equivalent immediately
available funds.

      As security for the payment of this Note, the Company grants North Coast,
its successors and assigns, a continuing security interest in all assets of the
Company.

      In the event of an equity financing by the Company, North Coast, at North
Coast's option, may convert any or all of the outstanding principal of and
interest accrued on this Note into the securities offered in such financing, at
the offering price per share of such financing. For purposes of this paragraph,
"equity financing" means the issuance by the Company of capital stock or
securities convertible into capital stock, in one or more related closings.
"Equity financing" does not include options to purchase common stock issued to
employees, officers or directors of, or consultants or advisors to the Company
or any subsidiary pursuant to any bona fide incentive stock option plan, as may
be adopted by the Company from time to time, and any stock issued upon exercise
of such options. No fractional securities shall be issued upon the exercise of
this conversion right and any fractional amount shall be paid in cash.

      Subject to the other terms and conditions of this Note, if Nematron does
not complete an equity financing pursuant to which it receives gross proceeds of
at least $1.5 million on or before August 31, 2002, the principal and interest
due and payable under this Note may be converted by North Coast, in whole or in
part, into shares of Common Stock or Series A Preferred Stock of Nematron with
term and conditions consistent with those listed in Schedule A ("Series A
Preferred") beginning on September 1, 2002, upon at least three (3) business
days prior written notice from North Coast to Nematron and prior to the payment
of this Note in full (the "Conversion Option"). Nematron shall provide to North
Coast at least five (5) business days prior written notice before making any
payments under the Note. The number of shares of Series A Preferred issuable
upon exercise of the Conversion Option shall be equal to (x) the sum of the
principal and interest then due and payable under this Note, divided by (y)
$0.10. The number of shares of Common Stock issuable upon exercise of the
Conversion Option shall be equal to (x) the sum of the principal and interest
then due and payable under this Note, divided by (y) the lowest price per share
of Nematron Common Stock as traded on The AMEX if such AMEX closing price for
five consecutive trading days is below $0.18 per share.

      The proceeds of advances to the Company shall be used only for product
development, expansion of marketing and sales activities and to fund working
capital (including the repayment of the Company's operating line of credit).

      Upon the Company's draw down of amounts under this Note, North Coast is
entitled to receive warrants to purchase shares of the Company's Common Stock,
no par value, in an amount and at a price to be determined by mutual agreement
between the parties and under the same terms as set forth in a certain Warrant
Agreement between the Company and North Coast dated March 23, 2001. The warrant
exercise price shall be $0.10 per share and the number of shares shall equal 20%
of the amount advanced under this note divided by $0.10.

                                       2
<PAGE>
      THE COMPANY AND THE NORTH COAST, AFTER CONSULTING OR HAVING HAD THE
OPPORTUNITY TO CONSULT WITH COUNSEL, KNOWINGLY, VOLUNTARILY AND INTENTIONALLY
WAIVE ANY RIGHT EITHER OF THEM MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION
BASED UPON OR ARISING OUT OF THIS NOTE, OR ANY COURSE OF CONDUCT, DEALING,
STATEMENT (WHETHER ORAL OR WRITTEN) OR ACTIONS OF EITHER OF THEM. NEITHER THE
COMPANY NOR THE NORTH COAST SHALL SEEK TO CONSOLIDATE, BY COUNTERCLAIM OR
OTHERWISE, ANY ACTION IN WHICH A JURY TRIAL HAS BEEN WAIVED WITH ANY OTHER
ACTION IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED.

      Nematron hereby waives demand, presentment, protest, dishonor and notice
of dishonor in connection with this Note. In the event any action is taken to
collect or enforce the indebtedness evidenced by this Note or any part thereof,
the undersigned agrees to pay, in addition to the principal and interest due and
payable hereon, all reasonable costs of collecting this Note, including
reasonable attorneys' fees and expenses.

      This Note may not be sold, assigned or otherwise transferred without the
prior written consent of the Company, which consent shall not be unreasonably
withheld.

      This Note is made under, and shall be governed by and construed in
accordance with, the laws of the State of Michigan as to notes made and
performed entirely within such State and without giving effect to choice of law
principles of such State.

      Notwithstanding any provision in this Note to the contrary, the Company
shall not be required to issue any other securities if such issuance would
constitute a violation of any applicable Federal or state securities law or any
other law or regulation.

<TABLE>
<S>                                    <C>
NEMATRON CORPORATION                   ACCEPTED AND AGREED:

   /s/ Matthew S. Galvez               North Coast Technology Investors, LP
----------------------------------     -------------------------------------
By: Matthew S. Galvez, President
                                       By:  /s/ Hugo Braun                    [Signature]
                                           ---------------------------------
                                       Name: Hugo Braun
</TABLE>

Principal Business Addresses, Telephone and Fax Numbers:

5840 Interface Drive                  206 South Fifth Avenue, Suite 550
Ann Arbor, Michigan 48103             Ann Arbor, MI 48404
(734) 214-2128 (telephone)            (734) 662-7667 (telephone)
(734) 994-8170 (fax)                  (734) 662-6261 (fax)

                                       3
<PAGE>
                                SUMMARY OF TERMS
                        NEMATRON SERIES A PREFERRED STOCK

DIVIDENDS: No dividends will be required to be paid by Nematron (the "Company").
If any dividends are paid on the Company's common stock ("Common"), the holders
of the Series A Preferred shall be entitled to receive dividends in preference
to any dividend on the Common in an amount per share equal to or greater than
any dividend paid on the Common.

LIQUIDATION PREFERENCE: In the event of any liquidation or winding up of the
Company, the holders of the Series A Preferred shall be entitled to receive in
preference to the holders of Common an amount equal to the original issue price
for the Series A Preferred Stock. Thereafter, any remaining liquidation proceeds
will be distributed to the holders of the Series A Preferred and the Common on a
pro rata basis. A merger, consolidation or reorganization in which the
shareholders of the Company own less than 50% of the voting power of the
surviving company and any transaction or series of related transactions in which
in excess of 50% of the Company's voting power is transferred shall be treated
as a liquidation.

CONVERSION: Each holder of Series A Preferred shall have the right to convert
its shares at any time into shares of Common at the initial conversion rate of
1:1. The conversion rates shall be subject from time to time to antidilution
adjustments as set forth below.

VOTING RIGHTS: The holder of each share of Series A Preferred shall have the
right to that number votes equal to the number of shares of Common issuable upon
conversion of the Series A Preferred. The Series A Preferred shall vote with
Common on all matters except as specifically provided herein or as otherwise
required by law.

BOARD OF DIRECTORS: The holders of the Series A Preferred shall have the right
to elect one member to the Company's Board of Directors. If the holders of the
Series A Preferred choose not to exercise this right, the Series A Preferred
shall vote with Common in the election of directors.

PROTECTIVE PROVISIONS: Consent of a majority in interest of the Series A
Preferred will be required to (a) purchase or redeem any Common or Preferred
Stock, (b) authorize or issue any senior or parity securities, (c) declare or
pay dividends on or make any distribution on account of the Common, (d) merge,
consolidate or sell or assign all or substantially all of the Company's assets,
(e) increase or decrease authorized Preferred Stock and (f) amend Articles or
Incorporation to change the rights, preferences, privileges or limitations of
any Preferred Stock.

ANTIDILUTION: The conversion price for the Series A Preferred shall be subject
to proportional antidilution protection for stock splits, stock dividends, etc.
In the event that the Company issues additional shares of Common or Common
equivalents (other than shares issues to officers or employees of the Company
pursuant to plans approved by the Company's board of directors) at a purchase
price less than the applicable Series A Preferred conversion price, the Series A
Preferred conversion price shall be adjusted to that same lower purchase price.

RIGHTS OF FIRST REFUSAL: Each holder of Series A Preferred shall have the right
to participate in any Company financing up to its pro-rata ownership.

INFORMATION RIGHTS: Holders of Series A Preferred Stock shall have the right to
receive annual and quarterly financial statements and an annual business plan.

                                       4<PAGE>

                                                                    Exhibit 4.2

Dear [Investor]

This letter confirms our understanding relative to your second round of
investment in Mymetics Corporation. The key elements of our understanding are:

o    On December 31, 2003, you have subscribed to a capital increase of our
     Luxembourg fully owned affiliate, 6543 Luxembourg SA in the amount of EUR
     41'600 (approximately USD 50'000). On that same date, you have entered into
     a Share Exchange Agreement ("the Agreement") with Mymetics Corporation
     ("the Company"), a US company duly registered in the state of Delaware,
     currently traded OTCBB in the USA under the symbol MYMX. This Agreement
     entitles you to exchange your shares of 6543 Luxembourg SA against 500,000
     common shares of Mymetics Corporation. You have since exercised your right
     under the Agreement.

o    Concurrently with the transaction described above, we have undertaken to
     issue to you a warrant which shall irrevocably entitle you to acquire
     another 500,000 shares of Mymetics Corporation for the price of USD 50'000,
     such warrant to be exercised before June 30, 2004. This latter date has
     subsequently been extended to July 31, 2004.

o    You have recently confirmed your wish to invest another USD 250'000 in
     exchange of an additional 2,500,000 common shares of the Company.

o    You have also confirmed your wish to receive another warrant irrevocably
     entitling you to acquire another 2,500,000 shares of Mymetics Corporation
     for the same price of USD 250'000, such warrant to be exercised before July
     31, 2004.

o    You confirm and agree that your decision to invest is based on facts and
     data disclosed in Company filings made by the Company.

o    You have agreed that the 500,000 common shares to be issued to you pursuant
     to the first transaction described above and the 2,500,000 common shares to
     be issued to you pursuant to the new transaction contemplated herein shall
     be regrouped in a single issuance of 3,000,000 common shares to be issued
     to you as soon as feasible.

o    Similarly, you have agreed that the warrant entitling you to acquire
     another 500,000 common shares to be issued to you pursuant to the first
     transaction described above and the warrant entitling you to acquire
     another 2,500,000 common shares to be issued to you pursuant to the new
     transaction contemplated herein shall be regrouped in a single warrant
     entitling you to acquire 3,000,000 common shares before July 31, 2004 at a
     price of USD 0.10 per share.

                                       77
<PAGE>

We are happy and honored to accept your proposal. Therefore:

o    The Company hereby irrevocably undertakes to issue to you as soon as
     practically feasible three million common shares of Mymetics Corporation.

o    The Company hereby irrevocably undertakes to issue to you as soon as
     practically feasible a warrant that shall irrevocably entitle you to
     acquire three million common shares of Mymetics Corporation for the price
     of USD 300'000, such warrant to be exercised before July 31, 2004.

o    [Your Company] irrevocably agrees to transfer USD 250,000 to our account
     with [name of bank] as follows:

     [Bank details]

For the good order of our file, please kindly confirm your agreement with the
terms of this letter by signing its fax copy and faxing it back to us at either
of the following numbers:

[Fax numbers].

We thank you again for your interest in Mymetics and remain

With best regards

Mymetics Corporation                     Mymetics Corporation
Ernest Lubke                             Christian Rochet
Chief Financial Officer                  President and Chief Executive Officer

                                       78

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00063-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00063-of-00352.parquet"}]]