Document:

First Amendment to Scientific Advisory Agreement

 Exhibit 10.1 

FIRST AMENDMENT TO 

SCIENTIFIC ADVISORY AND CONSULTING AGREEMENT 

BY AND BETWEEN 

CURIS, INC. 
 AND

 Joseph M. Davie, Ph.D., M.D. 

This First Amendment (“Amendment”), effective as of June 3, 2010 (“Amendment Date”), is made by and between
Curis, Inc., having a place of business at 45 Moulton Street, Cambridge, MA 02138 (“Curis”) and Joseph M. Davie, Ph.D., M.D. (“Scientific Advisor”). Curis and Scientific Advisor may each be referred to individually as a
“Party” and collectively as the “Parties.” 
 WHEREAS, the Parties desire to make certain changes to the
Scientific Advisory and Consulting Agreement entered into between the Parties on September 14, 2006 (the “Agreement”) as further specified in this Amendment. 

NOW, THEREFORE, in consideration of the promises and of the mutual covenants herein contained, the Parties agree as follows: 

1. The first sentence of section 2(a) of the Agreement is hereby deleted in its entirety and replaced with the following: 

“The Scientific Advisor agrees to serve under the terms of this Agreement as a scientific advisor to Curis as a member of its
Scientific Advisory Board (“SAB”).” 
 2. The first sentence of section 4(a) of the Agreement is hereby deleted in its entirety
and replaced with the following: 
 “Curis shall pay Scientific Advisor compensation in the amount of Five Hundred Dollars
($500.00) per hour for services provided hereunder, payable within thirty (30) days after the performance of such services.” 

All other terms and conditions of the Agreement shall remain the same. 

ACCEPTED AND AGREED TO BY: 
  

									
	Scientific Advisor	 		 	Curis, Inc.
	  
 Signature:
	 	 /s/ Joseph M. Davie
	 		 	Signature:	 	 /s/ Michael P. Gray

					
	Name:	 	Joseph M. Davie, Ph. D., M.D.	 		 	Name:	 	Michael P. Gray
					
	Date:	 	June 3, 2010	 		 	Title:	 	COO and CFO
					
		 		 		 	Date:	 	June 3, 2010Officers' Certificate, dated August 3, 2010

 Exhibit 4.2 

SAFEWAY INC. 

OFFICERS’ CERTIFICATE PURSUANT TO 

SECTIONS 2.2 AND 10.4 OF THE INDENTURE 

August 3, 2010 

Steven A. Burd and Bradley S. Fox do hereby certify that they are the President and Chief Executive Officer, and the Vice President and
Treasurer, respectively, of Safeway Inc., a Delaware corporation (the “Company”), and do further certify, pursuant to resolutions of the Board of Directors of the Company adopted on December 5, 2008 (the
“Resolutions”), and in accordance with Sections 2.2 and 10.4 of the Indenture (the “Indenture”) dated as of September 10, 1997 between the Company and The Bank of New York Mellon Trust Company, N.A., formerly
known as The Bank of New York Trust Company, N.A., as successor to The Bank of New York, as trustee (the “Trustee”), as follows: 

1. Attached hereto as Annex A is a true and correct copy of a specimen note (the “Form of Note”)
representing the Company’s 3.950% Notes Due 2020 (the “Notes”). The Notes are a separate series of Securities under the Indenture. 

The Company is issuing initially $500 million in aggregate principal amount of the Notes. The Company may issue additional
Notes from time to time after the date hereof, and such additional Notes will be treated as a single class with the previously issued Notes for all purposes under the Indenture. No additional Notes may be issued if an Event of Default has occurred
with respect to such Notes. 
 2. The Form of Note sets forth certain of the terms required to be set forth in
this certificate pursuant to Section 2.2 of the Indenture, and said terms are incorporated herein by reference. The Notes were offered at an initial public offering price of 99.556% of the principal amount thereof. 

3. In addition to the covenants set forth in Article IV of the Indenture, the Notes shall include the following additional
covenants, and such additional covenants shall be subject to covenant defeasance pursuant to Section 8.4 of the Indenture: 

“Section 4.7 Limitation on Liens. 

The Company shall not, nor shall it permit any of its Subsidiaries to, create, incur, or permit to exist, any Lien on any
of their respective properties or assets, whether now owned or hereafter acquired, or upon any income or profits therefrom, in order to secure any Indebtedness of the Company, without effectively providing that the Notes shall be equally and ratably
secured until such time as such Indebtedness is no longer secured by such Lien, except: (i) Liens existing as of August 3, 2010 (the “Closing Date”); (ii) Liens granted after the Closing Date on any assets or
properties of the Company or any of its Subsidiaries securing Indebtedness of the Company created in favor of the Holders of the Notes; (iii) Liens securing Indebtedness of the Company which is incurred to extend, renew or refinance
Indebtedness which is secured by Liens permitted to be incurred under the Indenture; provided that such Liens do not extend to or cover any property or assets of the Company or any of its Subsidiaries other than the property or assets securing the
Indebtedness being refinanced and that the principal amount of such Indebtedness does not exceed the principal amount of the Indebtedness being refinanced; (iv) Permitted Liens; and (v) Liens created in substitution of or as replacements
for any Liens permitted by the preceding clauses (i) through (iv), provided that, based on a good faith determination of an officer 

 
of the Company, the property or asset encumbered under any such substitute or replacement Lien is substantially similar in nature to the property or asset encumbered by the otherwise permitted
Lien which is being replaced. 
 Notwithstanding the foregoing, the Company and any Subsidiary of the Company
may, without securing the Notes, create, incur or permit to exist Liens which would otherwise be subject to the restrictions set forth in the preceding paragraph, if after giving effect thereto and at the time of determination, Exempted Debt does
not exceed the greater of (i) 10% of Consolidated Net Tangible Assets or (ii) $350,000,000. 
 Section 4.8
Limitation on Sale and Lease-Back Transactions. 
 The Company shall not, nor shall it permit any of its
Subsidiaries to, enter into any sale and lease-back transaction for the sale and leasing back of any property or asset, whether now owned or hereafter acquired, of the Company or any of its Subsidiaries (except such transactions (i) entered
into prior to the Closing Date or (ii) for the sale and leasing back of any property or asset by a Subsidiary of the Company to the Company or (iii) involving leases for less than three years or (iv) in which the lease for the
property or asset is entered into within 120 days after the later of the date of acquisition, completion of construction or commencement of full operations of such property or asset) unless (a) the Company or such Subsidiary would be entitled
under Section 4.7 to create, incur or permit to exist a Lien on the assets to be leased in an amount at least equal to the Attributable Liens in respect of such transaction without equally and ratably securing the Notes or (b) the proceeds
of the sale of the assets to be leased are at least equal to their fair market value and the proceeds are applied to the purchase or acquisition (or in the case of real property, the construction) of assets or to the repayment of Indebtedness of the
Company or a Subsidiary of the Company which by its terms matures not earlier than one year after the date of such repayment. 

Section 4.9 Offer to Purchase Upon Change of Control Triggering Event 

If a Change of Control Triggering Event occurs, unless the Company has exercised its option to redeem the Notes as
described in the Notes, the Company will make an offer (the “Change of Control Offer”) to each Holder of the Notes to repurchase all or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof) of that Holder’s
Notes. In the Change of Control Offer, the Company will offer payment in cash equal to 101% of the aggregate principal amount of Notes repurchased, plus accrued and unpaid interest, if any, on the Notes repurchased to the date of repurchase (the
“Change of Control Payment”). Within 30 days following any Change of Control Triggering Event or, at the Company’s option, prior to any Change of Control, but after public announcement of the transaction that constitutes or may
constitute the Change of Control, the Company will mail a notice to Holders of the Notes describing the transaction that constitutes or may constitute the Change of Control Triggering Event and offering to repurchase the Notes on the date specified
in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”). The notice will, if mailed prior to the date of consummation of the Change of
Control, state that the offer to purchase is conditioned on the Change of Control Triggering Event occurring on or prior to the Change of Control Payment Date. 

On the Change of Control Payment Date, the Company will, to the extent lawful: 

(i) accept for payment all Notes or portions of Notes properly tendered pursuant to the Change of Control Offer; 

 

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 (ii) deposit with the Paying Agent an amount equal to the Change of Control Payment in
respect of all Notes or portions of Notes properly tendered; and 
 (iii) deliver or cause to be delivered to the Trustee the
Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes or portions of Notes being repurchased. 

The Company will not be required to make a Change of Control Offer upon the occurrence of a Change of Control Triggering
Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and the third party repurchases all Notes properly tendered and not withdrawn under its offer.
In addition, the Company will not repurchase any Notes if there has occurred and is continuing on the Change of Control Payment Date an Event of Default under this Indenture, other than a default in the payment of the Change of Control Payment upon
a Change of Control Triggering Event. 
 The Paying Agent will promptly pay to each Holder of Notes so tendered
the Change of Control Payment for such Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book entry) to each Holder a new Note equal in principal amount to any unpurchased portion of the Notes surrendered, if
any; provided that each such new Note will be in a principal amount of $2,000 or an integral multiple of $1,000 in excess thereof. 

The Company will comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and
regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that the provisions of any such securities laws or
regulations conflict with the Change of Control Offer provisions of the Notes, the Company will comply with those securities laws and regulations and will not be deemed to have breached its obligations hereunder by virtue of any such conflict.”

 4. In addition to the Events of Default set forth in Section 6.1 of the Indenture, the Notes shall
include the following additional Event of Default, which shall be deemed an Event of Default under Section 6.1(g) of the Indenture: 

“acceleration of $150,000,000 or more, individually or in the aggregate, in principal amount of Indebtedness of the
Company under the terms of the instrument under which such Indebtedness is issued or secured, except as a result of compliance with applicable laws, orders or decrees, if such Indebtedness shall not have been discharged or such acceleration is not
annulled within 10 days after written notice.” 
 5. In addition to the definitions set forth in Article I
of the Indenture, the Notes shall include the following additional definitions, which, in the event of a conflict with the definition of terms in the Indenture, shall control: 

“Attributable Liens” means in connection with a sale and lease-back transaction the lesser of (a) the fair
market value of the assets subject to such transaction and (b) the present value (discounted at a rate per annum equal to the average interest borne by all outstanding Securities issued under the Indenture determined on a weighted average basis
and compounded semi-annually) of the obligations of the lessee for rental payments during the term of the related lease. 
  

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 “Bank Credit Agreement” means the Credit Agreement dated as of
June 1, 2005 by and among Safeway Inc. and Canada Safeway Limited, as borrowers, Banc of America Securities LLC and J.P. Morgan Securities Inc., as joint lead arrangers, Deutsche Bank AG New York Branch, as administrative agent, Bank of
America, N.A., JPMorgan Chase Bank, National Association, Citicorp USA, Inc. and BNP Paribas, as co-syndication agents, U.S. National Bank Association, as documentation agent, and the lenders that are parties thereto, as such agreement may be
amended (including any amendment, restatement, refinancing and successors thereof), supplemented or otherwise modified from time to time, including any increase in the principal amount of the obligations thereunder. 

“Capital Lease” means any Indebtedness represented by a lease obligation of a person incurred with respect to
real property or equipment acquired or leased by such person and used in its business that is required to be recorded as a capital lease in accordance with GAAP. 

“Change of Control” means the occurrence of any of the following: (1) the direct or indirect sale,
transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or substantially all of the Company’s properties or assets and those of its Subsidiaries taken as a
whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its Subsidiaries; (2) the consummation of any transaction (including, without limitation, any merger or
consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) (other than the Company or one of its Subsidiaries) becomes the beneficial owner (as defined in Rules 13d-3 and
13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed, measured by voting power
rather than number of shares; or (3) the first day on which a majority of the members of the Board of Directors are not Continuing Directors. Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control if
(1) the Company becomes a direct or indirect wholly-owned Subsidiary of a holding company and (2)(A) the direct or indirect holders of the Voting Stock of such holding company immediately following that transaction are substantially the
same as the holders of the Company’s Voting Stock immediately prior to that transaction or (B) immediately following that transaction no person (other than a holding company satisfying the requirements of this sentence) is the beneficial
owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company. 
 “Change of
Control Triggering Event” means the occurrence of both a Change of Control and a Rating Event. 

“Consolidated Net Tangible Assets” means the total amount of assets of the Company and its Subsidiaries (less
applicable depreciation, amortization and other valuation reserves) after deducting therefrom (i) all current liabilities of the Company and its Subsidiaries and (ii) all goodwill, trade names, trademarks, patents, unamortized debt
discount and expenses and other like intangibles, determined on a consolidated basis in accordance with GAAP. 

“Continuing Directors” means, as of any date of determination, any member of the Board of Directors who
(1) was a member of the Board of Directors on the date the Notes were issued or (2) was nominated for election, elected or appointed to the Board of Directors with the approval of a majority of the Continuing Directors who were members of
the Board of Directors at the times of such nomination, election or appointment (either by a specific vote or by approval of the Company’s proxy statement in which such member was named as a nominee for election as a director, without objection
to such nomination). 
  

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 “Currency Agreement” means any foreign exchange contract, currency
swap agreement or other similar agreement or arrangement designed to protect the Company or any of its Subsidiaries against fluctuations in currency values. 

“Exempted Debt” means the sum of the following as of the date of determination: (i) Indebtedness of the
Company incurred after the Closing Date and secured by Liens not otherwise permitted by the first sentence under Section 4.7, and (ii) Attributable Liens of the Company and its Subsidiaries in respect of sale and lease-back transactions
entered into after the Closing Date, other than sale and lease-back transactions permitted by the limitation on sale and lease-back transactions set forth under Section 4.8. For purposes of determining whether or not a sale and lease-back
transaction is “permitted” by Section 4.8, the last paragraph under Section 4.7 (creating an exception for Exempted Debt) will be disregarded. 

“Fitch” means Fitch Ratings Ltd. 

“Indebtedness” of any person means, without duplication, any indebtedness, whether or not contingent, in respect
of borrowed money or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements with respect thereto) or representing the balance deferred and unpaid of the purchase price of any property
(including pursuant to Capital Leases), except any such balance that constitutes an accrued expense or trade payable, if and to the extent any of the foregoing indebtedness would appear as a liability upon a balance sheet of such person prepared on
a consolidated basis in accordance with GAAP (but does not include contingent liabilities which appear only in a footnote to a balance sheet), and shall also include, to the extent not otherwise included, the guaranty of items which would be
included within this definition. 
 “Interest Swap Obligations” means the obligations of any person
pursuant to any interest rate swap agreement, interest rate collar agreement or other similar agreement or arrangement designed to protect such person or any of its Subsidiaries against fluctuations in interest rates. 

“Investment Grade Rating” means a rating equal to or higher than BBB- (or the equivalent) by Fitch, Baa3 (or the
equivalent) by Moody’s and BBB- (or the equivalent) by S&P, and the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected by the Company. 

“Joint Venture” means a joint venture, partnership or other similar arrangement, whether in corporate,
partnership or other legal form; provided that, as to any such arrangement in corporate form, such corporation shall not, as to any person of which such corporation is a Subsidiary, be considered to be a Joint Venture to which such person is a
party. 
 “Lien” means any lien, security interest, charge or encumbrance of any kind (including any
conditional sale or other title retention agreement, any lease in the nature thereof, and any agreement to give any security interest). 

“Moody’s” means Moody’s Investors Service, Inc. 

“Permitted Liens” means (i) Liens securing Indebtedness of the Company under the Bank Credit Agreement and
any initial or subsequent renewal, extension, refinancing, replacement or refunding thereof; (ii) Liens on accounts receivable, merchandise inventory, equipment, and patents, trademarks, trade names and other intangibles, securing Indebtedness
of the Company; (iii) Liens on any asset of the Company, any Subsidiary of the Company, or any Joint Venture to which the Company or any of its Subsidiaries is a party, created solely to secure obligations

  

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incurred to finance the refurbishment, improvement or construction of such asset, which obligations are incurred no later than 24 months after completion of such refurbishment, improvement or
construction, and all renewals, extensions, refinancings, replacements or refundings of such obligations; (iv)(a) Liens given to secure the payment of the purchase price incurred in connection with the acquisition (including acquisition through
merger or consolidation) of property (including shares of stock), including Capital Lease transactions in connection with any such acquisition, and (b) Liens existing on property at the time of acquisition thereof or at the time of acquisition
by the Company or a Subsidiary of the Company of any person then owning such property whether or not such existing Liens were given to secure the payment of the purchase price of the property to which they attach; provided that, with respect
to clause (a), the Liens shall be given within 24 months after such acquisition and shall attach solely to the property acquired or purchased and any improvements then or thereafter placed thereon; (v) Liens in favor of customs and revenue
authorities arising as a matter of law to secure payment of customs duties in connection with the importation of goods; (vi) Liens upon specific items of inventory or other goods and proceeds of any person securing such person’s
obligations in respect of bankers’ acceptances issued or created for the account of such person to facilitate the purchase, shipment or storage of such inventory or other goods; (vii) Liens securing reimbursement obligations with respect
to letters of credit that encumber documents and other property relating to such letters of credit and the products and proceeds thereof; (viii) Liens on key-man life insurance policies granted to secure Indebtedness of the Company against the
cash surrender value thereof; (ix) Liens encumbering customary initial deposits and margin deposits and other Liens in the ordinary course of business, in each case securing Indebtedness of the Company under Interest Swap Obligations and
Currency Agreements and forward contract, option, futures contracts, futures options or similar agreements or arrangements designed to protect the Company or any of its Subsidiaries from fluctuations in interest rates, currencies or the price of
commodities; (x) Liens arising out of conditional sale, title retention, consignment or similar arrangements for the sale of goods entered into by the Company or any of its Subsidiaries in the ordinary course of business; and (xi) Liens in
favor of the Company or any Subsidiary of the Company. 
 “Rating Agencies” means (1) each of
Fitch, Moody’s and S&P; and (2) if any of Fitch, Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Company’s control, a “nationally
recognized statistical rating organization” within the meaning of Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act selected by the Company as a replacement agency for Fitch, Moody’s or S&P, or all of them, as the case may be.

 “Rating Event” means the rating on the Notes is lowered by each of the Rating Agencies, and the
Notes are rated below an Investment Grade Rating by each of the Rating Agencies on any day within the 60-day period (which 60-day period will be extended so long as the rating of the Notes is under publicly announced consideration for a possible
downgrade by any of the Rating Agencies) after the earlier of (1) the occurrence of a Change of Control and (2) public notice of the occurrence of a Change of Control or the Company’s intention to effect a Change of Control;
provided, however, that a Rating Event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control (and thus will not be deemed a Rating Event for purposes
of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Trustee in writing at the Company’s
or the Trustee’s request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of Control (whether or not the applicable Change of
Control has occurred at the time of the Rating Event). 
  

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 “S&P” means Standard & Poor’s Rating Services, a
division of The McGraw-Hill Companies, Inc. 
 “Voting Stock” means, with respect to any specified
“person” (as that term is used in Section 13(d)(3) of the Exchange Act) as of any date, the Capital Stock of such person that is at the time entitled to vote generally in the election of the board of directors of such person.

 6. Each of the undersigned is authorized to approve the form, terms and conditions of the Notes pursuant to
the Resolutions. 
 7. Attached hereto as Annex B is a true and correct copy of the Resolutions.

 8. The Notes shall be issued as Global Securities (subject to exchange for definitive certificated Notes under
the circumstances provided in the Indenture) and The Depository Trust Company shall be Depository for the Notes. 

9. Attached hereto as Annex C is a true and correct copy of the letter addressed to the Trustee entitling the
Trustee to rely on certain paragraphs of the Opinion of Counsel attached thereto, which Opinion relates to the Notes and is delivered in compliance with Section 10.4(b) of the Indenture. 

10. Each of the undersigned has reviewed the provisions of the Indenture, including the covenants and conditions precedent
pertaining to the issuance of the Notes. 
 11. In connection with this certificate each of the undersigned has
examined documents, corporate records and certificates and has spoken with other officers of the Company. 
 12.
Each of the undersigned has made such examination and investigation as is necessary to enable the undersigned to express an informed opinion as to whether or not the covenants and conditions precedent of the Indenture pertaining to the issuance of
the Notes have been satisfied. 
 13. In our opinion all of the covenants and conditions precedent provided for
in the Indenture for the issuance of the Notes have been satisfied. 
 Terms used herein that are not otherwise defined shall
have the meanings ascribed thereto in the Indenture or the Notes, as the case may be. 
 [Signature Page Follows] 

 

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 IN WITNESS WHEREOF, each of the undersigned officers has executed this certificate as of the
date first written above. 
  

	
	 /s/ Steven A. Burd

Steven A. Burd
 President and Chief Executive
Officer

	
	 /s/ Bradley S. Fox

Bradley S. Fox
 Vice President and
Treasurer

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