Document:

Pledge Agreement, dated as of February 25, 2008

 Exhibit 4.15 
 EXECUTION VERSION 
 AXCAN LUXCO 1 S.AR.L. 
 AS PLEDGOR 
 AND 
 BANK OF AMERICA, N.A. 
 AS ADMINISTRATIVE AGENT 
 (AND COLLATERAL AGENT) 
 AND 
 AXCAN LUXCO 2 S.AR.L. 
 AS COMPANY 
 PLEDGE AGREEMENT 
 relating to the
Shares, PECs and PPCs 
 issued by Axcan LuxCo 2 S.àr.l 
 dated 25 February, 2008 

 THIS PLEDGE AGREEMENT (hereafter the “Agreement”) is entered into and dated 25 February,
2008 
 BY and BETWEEN 
  

	(1)	Axcan LuxCo 1 S.à r.l., a société à responsabilité limitée incorporated under the laws of the Grand Duchy of Luxembourg, with
its registered office at 5, rue Eugène Ruppert, L-2453 Luxembourg, registration with the Registre de Commerce et des Sociétés de Luxembourg pending (the “Pledgor”); 

 AND 
  

	(2)	Bank of America, N.A., a national banking association organized and existing under the laws of the United States of America, with its principal place of business at One
Independence Center, 101 N. Tryon St., Charlotte, N.C. acting for itself and as Administrative Agent and Collateral Agent for itself and for the Secured Parties, (and any of its successors or assignees) (the “Collateral Agent”);

 In the Presence of 
  

	(3)	Axcan LuxCo 2 S.à r.l., a société à responsabilité limitée incorporated under the laws of the Grand Duchy of Luxembourg, with
its registered office at 5, rue Eugène Ruppert, L-2453 Luxembourg, registration with the Registre de Commerce et des Sociétés de Luxembourg pending (the “Company”). 

 WHEREAS 
  

	(A)	The Pledgor is the sole holder of all the shares in issue in the Company and is or will become the sole owner (upon issue thereof) of all the PECs and PPCs issued by the Company.

  

	(B)	Reference is made to (i) the Credit Agreement dated as of February 25, 2008 (as amended, amended and restated, supplemented or otherwise modified from time to time however
substantially, the “Credit Agreement”), among the Axcan Intermediate Holdings Inc. (“Axcan Holdco”) as Parent Borrower, Axcan US Partnership 1 LP, as Co-Borrower (together with the Parent Borrower, the “Borrowers”),
Axcan MidCo Inc., as “Holdings”, Bank of America, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer, and each lender from time to time party thereto (collectively, the “Lenders”), and (ii) the Senior Secured
Notes and the Senior Secured Notes Indenture. 

  

	(C)	The Pledgor is a subsidiary of Axcan Holdco which is the Parent Borrower under the Credit Agreement and the issuer of the Senior Secured Notes and the Pledgor will derive
substantial benefits from the extension of credit to the Borrowers pursuant to the Credit Agreement, and from the issue of the Senior Secured Notes, and is willing to execute, deliver and perform this Agreement and to grant the Pledge hereunder.

  

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 IT IS THEREFOR AGREED as follows: 
 Clause 1. DEFINITIONS AND INTERPRETATION 
 1.1. Capitalized terms used in this Agreement and not otherwise defined
herein have the meanings specified in the Credit Agreement or as the case may be the US Security Agreement, and the following terms have the following meanings: 
  

			
	Business Day	  	means a day (other than a Saturday or Sunday) on which banks are open for business in the City of Luxembourg, Grand Duchy of Luxembourg and New York City
		
	Collateral Law	  	the Luxembourg law of 5th August 2005 on financial collateral arrangements
		
	Credit Agreement	  	has the meaning as given thereto in recital (B)
		
	Credit Facilities Obligations	  	shall have the meaning set forth in the US Security Agreement
		
	Equal and Ratable Period	  	shall have the meaning set forth in the US Security Agreement
		
	Event of Default	  	shall have the meaning set forth in the US Security Agreement
		
	Future Securities	  	means any Future Shares, Future PECs and/or Future PPCs
		
	Loan Documents	  	shall have the meaning as set forth in the US Security Agreement
		
	Other Secured Agreements	  	shall have the meaning set forth in the US Security Agreement
		
	PECs	  	means 100% of the preferred equity certificates issued by the Company and held by the Pledgor at any time, including for the avoidance of doubt any PECs which may be issued by the Company to the
Pledgor from time to time after the date hereof, regardless of the reason for such issuance (“Future PECs”), in which case such Future PECs and the Related Assets in relation thereto shall immediately be and become subject to the
security interest created hereunder
		
	Pledge	  	means the pledge (gage) on the Pledged Assets constituted by this Agreement
		
	Pledged Assets	  	means the Securities, and Future Securities and the Related Assets

  

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	PPCs	  	means 100% of the profit participating certificates issued by the Company and held by the Pledgor at any time, including for the avoidance of doubt any PPCs which may be issued by the Company to
the Pledgor from time to time after the date hereof, regardless of the reason for such issuance (“Future PPCs”), in which case such Future PPCs and the Related Assets in relation thereto shall immediately be and become subject to
the security interest created hereunder
		
	Register	  	means the register of Shares, the register of PECs and/or the register of PPCs of the Company, as appropriate
		
	Related Assets	  	means all dividends, interest and other monies payable in respect of the Shares, the PECs and the PPCs as applicable, and all other rights, benefits and proceeds in respect of or derived from
the Shares , the PECs and the PPCs (whether by way of redemption, bonus, preference, option, substitution, conversion, disposal or otherwise)
		
	Replacement Credit Facility	  	shall have the meaning set forth in the US Security Agreement
		
	Secured Agreements	  	shall have the meaning set forth in the US Security Agreement
		
	Secured Obligations	  	shall have the meaning as set forth in the US Security Agreement (but excluding always any advances, loans or debts made in respect to the issue of Shares of the Pledgor)
		
	Secured Parties	  	shall have the meaning as set forth in the US Security Agreement
		
	Securities	  	Means the Shares, the PECs, the PPCs and to the extent relevant the Future Securities
		
	Senior Secured Notes	  	shall have the meaning as set forth in the US Security Agreement
		
	Senior Secured Notes Indenture	  	shall have the meaning as set forth in the US Security Agreement
		
	Shares	  	means 100% of the shares in the share capital of the Company and held by the Pledgor at any time, including for the avoidance of doubt any shares in the share capital of the Company which may be
issued to the Pledgor from time to time after the date hereof, regardless of the reason for such issuance (“Future Shares”), in which case such number of Future Shares and the Related Assets in relation thereto shall immediately be
and become subject to the security interest created hereunder

  

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	US Securities Act	  	means the United States Securities Act of 1933
		
	US Security Agreement	  	means the New York law governed Pledge and Security Agreement executed inter alia by the Borrowers, Holdings and Bank of America, N.A. on or about the date hereof (as it may be amended, amended
and restated, modified or supplemented)(defined as US Security Agreement in the Credit Agreement)
		
	US SEC	  	means the United States Securities and Exchange Commission

 1.2. The meanings of defined terms are equally applicable to the singular and plural forms of the defined terms.

 1.3. In this Agreement, any reference to (a) a “Clause” is, unless otherwise stated, a reference to a Clause hereof and (b) to any
agreement (including this Agreement) is a reference to such agreement as amended, varied, modified or supplemented (however fundamentally) from time to time. Clause headings are for ease of reference only. 
 1.4. At my time other than during an Equal and Ratable Period, references herein to the Credit Agreement (including references to specific sections thereof) shall be
deemed to be references to the Credit Agreement as in effect on the date hereof (as the same has been amended, amended and restated, supplemented or otherwise modified from time to time). During any Equal and Ratable Period, references herein to the
Credit Agreement (including references to specific sections thereof) shall be deemed to be references, mutatis mutandis, to the Credit Agreement or Replacement Credit Facility (as applicable) as then in effect. 
 1.5. This Agreement may be executed in any number of counterparts and by way of facsimile exchange or exchange by electronic transmission of executed signature pages,
all of which together shall constitute one and the same Agreement. 
 Clause 2. DECLARATION OF PLEDGE 
 2.1. As security for the payment or performance, as the case may be, in full when due, whether at stated maturity, by required prepayment, declaration, acceleration,
demand or otherwise of its Secured Obligations, the Pledgor hereby pledges, and the Collateral Agent acting as Administrative Agent and Collateral Agent for itself and for the Secured Parties, accepts, all of the Pledged Assets, as continuing first
ranking security (“gage”) in favour of the Collateral Agent in accordance in particular with the Collateral Law and article 114 and following of the Luxembourg Commercial Code. 
 2.2. For the avoidance of doubt, the Pledgor confirms, and the Collateral Agent accepts, that any Securities issued to (or acquired by, or exchanged with the Securities
existing on the date hereof in my way) the Pledgor after the date hereof, are immediately subject to the Pledge upon issuance to (or acquisition by or exchange by) the Pledgor. 
  

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 2.3. Notwithstanding anything else contained in this Agreement, in the event that Rule 3-16 of Regulation S-X under the
US Securities Act would require (or is replaced with another rule or regulation, or any other law, rule or regulation is adopted, which would require) (such law, rule or regulation, as amended or replaced with another rule or regulation
“Rule 3-16”) the filing with the US SEC of separate financial statements of any Affiliate of the Parent Borrower due to the fact that a security interest in such Affiliate’s Equity Interests or other securities has been granted
hereunder as security for the payment or performance, as the case may be, of any Other Secured Obligations then, solely to the extent securing such Other Secured Obligations, (i) the security interest granted pursuant to this Agreement or any
other Loan Document in such Equity Interests or other securities (the “3-16 Excluded Collateral”) shall automatically be deemed to be released and (ii) the 3-16 Excluded Collateral shall automatically be deemed to not be, and
to not have been, Pledged Assets, in each case to the extent necessary to render such requirement inapplicable. In such event, this Agreement or any other Loan Document may be amended or modified, without the consent of any Secured Party, to the
extent necessary to evidence the release of the Liens on the Equity Interests or other securities that are so deemed no longer to constitute Pledged Assets. For avoidance of doubt, nothing in this paragraph shall result in any release or termination
of the security interest granted pursuant to this Agreement or any other Loan Document in any 3-16 Excluded Collateral to the extent such security interest secures the Credit Facilities Obligations or any Permitted Secured Debt in the form of term
loans. 
 2.4. The Company recognises and accepts the Pledge in accordance with the provisions of Luxembourg law. 
 Clause 3. PERFECTION OF PLEDGE 
 3.1. The Parties hereto agree that in
compliance with and satisfaction of the dispossession requirement, (i) the Pledge is acknowledged and accepted by the Company and (ii) the Pledge shall be inscribed in the relevant Register of the Company. 
 3.2. The Pledgor and the Collateral Agent request and instruct the Company, and the Company, by signing this Agreement, undertakes, to promptly after the execution of
this Agreement, (i) inscribe the Pledge over the Pledged Assets in the relevant Register as first ranking pledge for the benefit of the Collateral Agent (and the Secured Parties) subject to Liens created by or permitted under the Loan Documents
and (ii) provide the Collateral Agent with a copy of the relevant Register evidencing such inscription. The wording for such registration is set forth in Schedule 1. 
 3.3. Without prejudice to the above provisions, the Pledgor hereby irrevocably authorises and empowers the Collateral Agent to cause any formal steps to be taken by the managers or other officers of the Company for
the purpose of perfecting the present Pledge and, for the avoidance of doubt, the Pledgor hereby irrevocably undertakes to take any such steps if so requested in writing by the Collateral Agent (acting reasonably). In particular, should any such
steps be reasonably required in relation to Future Securities, the Pledgor and the Company undertake (without prejudice to the right of the Collateral Agent herein) to take any such steps promptly upon issuance or receipt of any Future Securities.

  

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 Clause 4. RIGHTS RELATING TO THE PLEDGED SECURITIES 
 4.1. Unless and until an Event of Default shall have occurred and be continuing and the Collateral Agent shall have provided not less than 10 days’ prior notice to the Pledgor that the rights of the Pledgor under
this clause 4 are being suspended, 
 4.1.1. the Pledgor shall be entitled to receive and retain any and all dividends, interest, principal and other
distributions paid on or distributed in respect of the Pledged Assets to the extent and only to the extent that such dividends, interest, principal and other distributions are permitted by, and otherwise paid or distributed in accordance with, the
terms and conditions of the Credit Agreement and the other Loan Documents; provided that any noncash (and non-cash equivalent) dividends, interest, principal or other distributions that would constitute Pledged Assets, whether resulting from a
subdivision, combination or reclassification or received in exchange for the Pledged Assets, or in redemption thereof, or as a result of any merger, consolidation, acquisition or other exchange of assets to which such issuer may be a party or
otherwise, shall be and become part of the Pledged Assets. So long as no Event of Default has occurred that is continuing, the Collateral Agent shall promptly, if requested by the Pledgor, take such actions in relation to the Pledge on the Pledged
Assets in its capacity as Security Agent requested to be taken in connection with any exchange, redemption or disposition of such Pledged Assets provided that the Parent Borrower has delivered to the Collateral Agent a Responsible Officer
Certificate certifying that such exchange, redemption or disposition is permitted under the Credit Agreement. 
 4.1.2. the Pledgor shall be entitled to
exercise any and all voting and/or other consensual rights and powers inuring to an owner of the Pledged Assets or any part thereof for any purpose consistent with the terms of this Agreement, the Credit Agreement and the other Loan Documents;
provided that such rights and powers shall not be exercised in any manner, except as may be permitted under this Agreement, the Credit Agreement or the other Loan Documents, that would materially and adversely affect the rights and remedies of any
of the Collateral Agent or the other Secured Parties under this Agreement, the Credit Agreement or any other Loan Document or the ability of the Secured Parties to exercise the same. The Collateral Agent shall execute and deliver to the Pledgor, or
cause to be executed and delivered to the Pledgor, all such proxies, powers of attorney and other instruments or consents as the Pledgor may reasonably request for the purpose of enabling the Pledgor to exercise the voting and/or consensual rights
and powers it is entitled to exercise pursuant to this paragraph. 
 4.2. Upon the occurrence and during the continuance of an Event of Default, after the
Collateral Agent shall have provided the Pledgor with 10 days’ prior notice of the suspension of the rights of the Pledgor under clause 4.1, 
 4.2.1.
all rights of the Pledgor to dividends, interest, principal or other distributions in relation with the Pledged Assets and all such rights shall thereupon become vested in the Collateral Agent, which shall have the sole and exclusive right and
authority to on demand receive and retain such dividends, interest, principal or other distributions. Any and all money and other property paid over to or received by the Collateral Agent pursuant to the provisions hereof shall be retained by the
Collateral Agent in an account to be established by the Collateral Agent upon receipt of such money or other property and shall be applied in accordance with the provisions of the Credit Agreement. After all Events of Default have been cured or
waived, the Collateral Agent shall promptly repay to the Pledgor (without interest) all dividends, interest, principal or other distributions to the Pledgor that the Pledgor would otherwise be permitted to retain pursuant to the terms hereof.

  

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 4.2.2. all rights of the Pledgor to exercise the voting and consensual rights and powers relating to the Pledged Assets
and all such rights shall thereupon become vested in the Collateral Agent to the largest extent permitted by law, which shall have the sole and exclusive right and authority to exercise such voting and consensual rights and powers; provided
that, unless otherwise directed by the Required Lenders, the Collateral Agent shall have the right from time to time following and during the continuance of an Event of Default to permit the Pledgor to exercise such rights at the discretion of the
Collateral Agent. The Pledgor shall take all steps reasonably requested by the Collateral Agent in order to ensure that the exercise of the voting and other rights by the Collateral Agent in these circumstances is facilitated and becomes possible
for the Collateral Agent, including but not limited to the issuance of a written proxy in any form required by applicable law. After all Events of Default have been cured or waived, the Pledgor shall have the exclusive right to exercise the voting
and/or consensual rights and powers relating to the Pledged Assets. The Collateral Agent shall take all steps reasonably requested by the Pledgor in order to ensure that the exercise of the voting and other rights by the Pledgor in these
circumstances is facilitated and becomes possible. 
 Clause 5. PLEDGOR’S REPRESENTATIONS, WARRANTIES AND COVENANTS 
 5.1. The Pledgor hereby represents, warrants and covenants to the Collateral Agent: 
 5.1.1. the Pledged Securities issued by the Company have been duly and validly authorized and issued, are fully paid and non-assessable and with respect to the PECs and PPCs are legal, valid and binding obligations of the Company;

 5.1.2. except for the security interests granted hereunder, the Pledgor is and, subject to any transfers permitted by the Credit Agreement, will continue
to be the direct owner and holder of the Pledged Assets, (ii) holds the same free and clear of all encumbrances, pledges, charges or other liens or any options or rights therein or thereto, other than (A) Liens created by the Collateral
Documents and (B) Liens expressly permitted pursuant to Section 7.01 of the Credit Agreement; 
 5.1.3. the Pledgor will make no assignment,
pledge, or hypothecation of, or transfer of or create or permit to exist any security interest in or other encumbrance or lien on, the Pledged Assets, other than the Pledge and other than (A) transfers permitted by the Credit Agreement,
(B) Liens created by the Collateral Documents and (C) Liens expressly permitted pursuant to Section 7.01 of the Credit Agreement; 
 5.1.4.
the Pledgor will not transfer (in any way including by way of sale, assignment or otherwise) the Pledged Assets (or any part thereof) other than with the prior written consent of the Collateral Agent or as may be permitted under the Credit
Agreement; 
 5.1.5. except for restrictions and limitations imposed by the Loan Documents or applicable laws generally, there are no agreements or
arrangements (including any restrictions on transfer or rights of pre-emption) in effect that might prohibit, impair, delay 

  

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or otherwise affect in any manner material and adverse to the Secured Parties the pledge of the Pledged Assets hereunder, the sale or disposition thereof
pursuant hereto or the exercise by the Collateral Agent of rights and remedies hereunder; 
 5.1.6. the Pledgor has the power and authority to pledge the
Pledged Assets hereunder; 
 5.1.7. no consent or approval of any Governmental Authority, any securities exchange or any other Person was or is necessary to
the validity of the Pledge (other than such as have been obtained and are in full force and effect); and 
 5.1.8. this Agreement operates a valid pledge of
the Pledged Assets in accordance with its terms and the Pledge created pursuant to this Agreement, creates a legal, valid, binding and enforceable first priority and first ranking security interest over the Pledged Assets in favour of the Collateral
Agent (and the Secured Parties) in respect of all Secured Obligations and in each case prior and superior to the rights of other persons, except for any mandatory privileges preferred by applicable law. 
 Clause 6. POWER OF ATTORNEY 
 The Pledgor appoints the Collateral
Agent to be its attorney and in its name and on its behalf to execute, deliver and perfect all documents (including any transfer forms and other instruments of transfer) and do all things that the Collateral Agent may consider to be requisite for
(a) carrying out any obligation imposed on the Pledgor under this Agreement or (b) exercising any of the rights conferred to it (and any of the Secured Parties) under this Agreement or by law, it being understood that the enforcement of
the Pledge over the Pledged Assets shall be carried out as described in Clause 7 hereunder. The Pledgor shall ratify and confirm all things lawfully done and all documents executed by the Collateral Agent in the exercise of this power of attorney,
provided that such powers of attorney shall not be exercisable prior to the occurrence and continuance of an Event of Default, save for such powers of attorney necessary for the perfection of the Pledge. 
 Clause 7. ENFORCEMENT OF THE PLEDGE 
 7.1. Following the occurrence of
an Event of Default, and as long as such Event of Default is continuing, unremedied or unwaived and without any notice other than as may be set forth in this respect elsewhere in this Agreement, the Collateral Agent shall be entitled to enforce the
Pledge or all or part of the Pledged Assets as permitted under the Credit Agreement, in the most favourable manner provided for by Luxembourg law at that time and in particular but without limitation: 
 7.1.1. to appropriate itself and/or for and on behalf of the Secured Parties all or part of the Pledged Assets at a price equal to the higher of (i) nominal value
of the relevant Security (including accrued unpaid interest or as the case may be declared unpaid dividends, if any thereon) or (ii) the market value of the relevant Pledged Assets as determined in accordance with Schedule 2 hereof; 

7.1.2. to sell all or part of the Pledged Assets in a private transaction at arm’s length terms (conditions commerciales normales); 
  

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 7.1.3. to cause the sale of all or part of the Pledged Assets, at a stock exchange selected by the Collateral Agent or by
public auction held at the place and at the time and if required by applicable law by the public officer, designated by the Collateral Agent; 
 7.1.4. to
request from the competent court, that title to all or part of the Pledged Assets be assigned or transferred to it, at a price determined by a court appointed expert; 
 7.1.5. in respect of any Related Assets consisting of claims for sums of money, to the extent that such sums are owed by the Company or a third party, to require the Company or such third party to make payment of the
amount due by it directly to the Collateral Agent; 
 7.2. Any proceeds of enforcement received by the Secured Parties or the Collateral Agent shall be
applied in accordance with the order set forth in Section 4.02 of the US Security Agreement. 
 Clause 8. EFFECTIVENESS OF SECURITY, RELEASE,
TERMINATION 
 8.1. The Pledge granted hereby and all other security interests or rights hereunder shall terminate with respect to all Credit Facilities
Obligations and any Liens arising therefrom that secure the Credit Facilities Obligations shall be automatically released upon the termination of each Equal and Ratable Period. 
 8.2. This Agreement, the Pledge granted hereby and all other security interests or rights hereunder shall terminate with respect to any Other Secured Obligations and any security interest hereunder shall be
automatically released when all the outstanding Other Secured Obligations other than contingent indemnification obligations not yet accrued and payable have been paid in full or defeased or discharged in accordance with their terns. 
 8.3. The Pledgor shall automatically be released from (i) during an Equal and Ratable Period, its obligations hereunder (and the Pledge shall be automatically
released) as provided in Section 9.11 (excluding Section 9.11(a)(i)) of, or otherwise in accordance with, the Credit Agreement or equivalent provision of, or otherwise in accordance with, any Replacement Credit Facility; provided
that the Credit Facility Lenders shall have consented to such transaction to the extent required by the Credit Agreement (or Replacement Credit Facility) and (ii) its obligations hereunder with respect to any Other Secured Obligations as
provided by the terms of the applicable Other Secured Agreement; provided that any consents required by the terms of the Other Secured Agreement shall have been obtained. 
 8.4. Upon any sale or other transfer by the Pledgor of any Pledged Assets that is permitted under (i) during an Equal and Ratable Period, the Credit Agreement or any Replacement Credit Facility and (ii) at
any time other than during an Equal and Ratable Period, the Other Secured Agreements, the security interest of such Pledgor in such Pledged Assets (but not in the proceeds thereof) shall be automatically released to the extent provided in the
applicable Secured Agreement. During an Equal and Ratable Period, upon the effectiveness of any written consent to the release of the security interest granted hereby in any Pledged Assets pursuant to Section 9.1 1 of the Credit Agreement or
equivalent provision of any Replacement Credit Facility, such security interest in such Pledged Assets (but not the proceeds thereof) shall be automatically released with respect 

  

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to all Secured Obligations. Upon the effectiveness of my written consent to the release of the security interest granted hereby in any Pledged Assets
pursuant to any Other Secured Agreement, such security interest in such Pledged Assets shall be released solely respect to the applicable Other Secured Obligations. 
 8.5. Notwithstanding anything to the contrary set forth in this Agreement, no release of the Pledgor from its obligations hereunder with respect to the Other Secured Obligations or of a Security Interest or security
interest granted hereunder with respect to the Other Secured Obligations shall occur pursuant to clause 8.3 and 8.4 above if the transactions or consents that would otherwise give rise to such release shall have occurred substantially concurrently
with or in contemplation of the end of an Equal and Ratable Period, unless such release is expressly permitted pursuant to the Other Secured Agreements or approved by the holders of the Secured Obligations arising thereunder. 
 8.6. Notwithstanding anything to the contrary set forth in this Agreement, (i) the obligations of the Loan Parties or any of their Restricted Subsidiaries under any
Secured Hedge Agreement and the Cash Management Obligations shall be secured pursuant to this Agreement only to the extent that, and for so long as, the other Obligations are so secured and (ii) any release of Pledged Assets effected in the
manner permitted by this Agreement shall nor require the consent of any Hedge Bank or Cash Management Bank. 
 8.7. In connection with any termination or
release pursuant to this Clause, the Collateral Agent shall execute and deliver to the Pledgor, at the Pledgor’s expense, all documents that the Pledgor shall reasonably request to evidence such termination or release, in each case in
accordance with the terms of Section 9.11 of the Credit Agreement. Any execution and delivery of documents pursuant to this Clause shall be without recourse to or warranty by the Collateral Agent. 
 8.8. For the avoidance of doubt, the Pledgor hereby waives any rights arising (if any) under Article 2037 of the Luxembourg Civil Code. 
 8.9. The Pledgor waives its right to the benefit of both “division” and “discussion”. 
 Clause 9. REASONABLE CARE 
 The Collateral Agent is required to
exercise reasonable care in the custody and preservation of any of the Pledged Assets in its possession; provided that the Collateral Agent shall be deemed to have exercised reasonable care in the custody and preservation of any of the Pledged
Assets, if such Pledged Assets is accorded treatment substantially similar to that which the Collated Agent accords its own property. 
 Clause 10.
COSTS, EXPENSES and INDEMNITY 
 10.1. The parties hereto agree that the Collateral Agent shall be entitled to reimbursement of its expenses incurred
hereunder and the indemnification as provided in Section 10.04 and 10.05 of the Credit Agreement to the extent permitted by law. 
  

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 10.2. Any such amounts payable as provided hereunder shall be additional Secured Obligations secured hereby. The
provisions of this clause shall remain operative and in full force and effect regardless of the termination of this Agreement or any other Loan Document, the consummation of the transactions contemplated hereby, the repayment of any of the Secured
Obligations, the invalidity or unenforceability of any term or provision of this Agreement or any other Loan Document, or any investigation made by or on behalf of the Secured Agent or any other Secured Party. All amounts due under this Clause 10.2
shall be payable within 10 days of written demand therefor. 
 Clause 11. NOTICES 
 Each notice or other communication required or permitted to be given under this Agreement shall be in writing and given as provided in Section 10.02 of the Credit Agreement, except as otherwise provided herein.
All such notices and communications shall be delivered to the addresses set out below: 
 To the Pledgor: 
 Axcan LuxCo 1 S.àr.l. 
 5, rue
Eugène Ruppert, 
 L-2453 Luxembourg 
 Attention: Board of Managers 
 Telecopy no: + 352 27 00 41 25 99 
 With a copy each time to
the Parent Borrower and the additional recipients for notice of the Parent Borrower as set forth in Section 10.02 of the Credit Agreement 
 To the Collateral Agent and/or the Secured Parties: 
 All notices to the Collateral Agent / Secured Parties shall be given as
set forth in Section 10.02 of the Credit Agreement. 
 To the Company: 
 Axcan LuxCo 2 S.àr.l. 
 5, rue
Eugène Ruppert, 
 L-2453 Luxembourg 
 Attention: Board of Managers 
 Telecopy no: + 352 27 00 41 25 99 
 Clause 12. SUCCESSORS 

12.1. Whenever in this Agreement any of the parties hereto is referred to, such reference shall be deemed to include the permitted successors and assigns of such
party; and all covenants, promises and agreements by or on behalf of the Pledgor, the Collateral Agent or the Secured Parties that are contained in this Agreement shall bind and inure to the benefit of their respective successors and assigns, to the
extent permitted under Section 10.07 of the Credit Agreement. 
  

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 12.2. For the purpose of Article 1278 of the Luxembourg Civil Code, to the extent required under law and without
prejudice to any other terms hereof or of the Loan Documents or other agreements referred to herein and in particular of Clause 12.1 hereabove, in the event of any assignment, transfer, novation or disposal of a part or all of its rights and
obligations by any Secured Party under any of the Secured Agreements to which such Secured Party is a party, all rights and privileges hereunder are expressly reserved. 
 12.3. The Pledgor may not assign or transfer all or any part of its rights or obligations hereunder, except with the prior approval of the Security Agent or as contemplated by this Agreement or the other Loan
Documents. 
 Clause 13. SEVERABILITY 
 Any provision of
this Agreement that is prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such
prohibition or unenforceability in any jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. 
 Clause
14. NO WAIVER; CUMULATIVE REMEDIES 
 No failure or delay by the Collateral Agent, or any other Secured Party in exercising any right or power hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of any such right or power, or any abandonment or discontinuance of steps to enforce such a right or power, preclude any other or further exercise thereof or the exercise of
any other right or power. The rights and remedies of the Collateral Agent, or any other Secured Party hereunder and under the other Loan Documents are cumulative and are not exclusive of any rights or remedies that they would otherwise have. Any
waiver or consent shall be effective only in the specific instance and for the purpose for which given. 
 Clause 15. AMENDMENTS 
 15.1. Neither this Agreement nor any terms or conditions hereof may be amended, changed, waived, discharged, terminated or otherwise modified unless such amendment,
change, waiver, discharge, termination or modification is in writing duly executed by or on behalf of the Pledgor and the Collateral Agent, subject to any consent required (i) during an Equal and Ratable Period, in accordance with
Section 10.01 of the Credit Agreement (or equivalent provision of any Replacement Credit Facility) and (ii) during any period other than an Equal and Ratable Period, in accordance with the Other Secured Agreements. Notwithstanding the
foregoing, the Collateral Agent and the Pledgor may, without the need to obtain the consent of any other Secured Party, waive, amend or modify any provision hereof (including by entering into new or supplemental agreements) to (i) cure any
ambiguity or defect herein, (ii), make technical, conforming and other changes necessary to reflect the termination in accordance with the Credit Agreement or Replacement Credit Facility of the Liens securing the Credit Facilities Obligations and to
give effect to the applicable collateral requirements of the Other Secured Agreements, (iii) upon the consummation of any Replacement Credit Facility, give effect to the applicable collateral requirements of such Replacement Credit Facility or
any other amendment required by 

  

 13 

 
such Replacement Credit Facility, to the extent consistent with the Other Secured Agreements and (iv) reflect the issuance of any Additional Secured
Debt Obligations that are secured on a junior basis to the Secured Obligations, as permitted by the Credit Agreement or any Replacement Credit Facility, as applicable. The Secured Parties, by accepting the benefits hereof, shall be deemed to have
consented to any amendment, waiver or modification in accordance with the immediately preceding sentence. 
 15.2. The Pledgor and the Company confirm that
they have received, and acknowledge hereby, a copy of the Secured Agreements (including without limitation the Credit Agreement) and of the US Security Agreement and in particular the reference to the defined terms herein. 
 Clause 16. GOVERNING LAW / JURISDICTION 
 16.1. This Agreement shall
be governed by and shall be construed in accordance with Luxembourg law. 
 16.2. With respect to any proceedings arising in connection with this Agreement,
the Pledgor and the Company irrevocably submit to the jurisdiction of the Luxembourg courts, notwithstanding the right of each Secured Party to take proceedings in any other competent jurisdiction. 
  

 14 

 IN WITNESS THEREOF the parties hereto have executed this Agreement in one or multiple original counterparts, all of which
together evidence the same Agreement, on the day and year first written above. 
 The Pledgor 
 Axcan LuxCo 2 S.àr.l. 
  

			
	By:	 	 /s/ David Mims

	Name:	 	David Mims
	Title:	 	Authorised Signatory

 Axcan LuxCo 2 S.àr.l. – Lux Pledge Agreement 

 The Collateral Agent 
 (as Administrative Agent and Collateral Agent for itself and for the Secured Parties, 
 (and any of its successors or assignees)) 

 Bank of America, N.A. 
  

			
	By:	 	 /s/ Mollie S. Canup

	Name:	 	Mollie S. Canup
	Title:	 	Vice President

 Axcan LuxCo 2 S.àr.l. – Lux Pledge Agreement 

			
	 The Company
 Axcan LuxCo 2
S.àr.l.

		
	By:	 	 /s/ David Mims

	Name:	 	David Mims
	Title:	 	Authorised Signatory

 Axcan LuxCo 2 S.àr.l. – Lux Pledge AgreementDeed of Pledge of Membership Rights, dated February 25, 2008

 Exhibit 4.16 
 DEED OF PLEDGE OF MEMBERSHIP 
 RIGHTS 
 (in relation to a $ 290,000,000 credit 
 agreement) 
 DATED 25 FEBRUARY 2008 
 among 
 AXCAN INTERMEDIATE HOLDINGS INC. 
 and

 AXCAN US LLC 
 as
Pledgors 
 and 
 BANK OF
AMERICA, N.A. 
 as Pledgee 
 and 
 AXCAN COÖPERATIEVE U.A. 
 as 
 Coop 

 INDEX 
  

					
	Clause	  	Page
	1	 	DEFINITIONS AND INTERPRETATION	  	2
	2	 	CREATION OF SECURITY	  	4
	3	 	PARALLEL DEBT	  	6
	4	 	REPRESENTATIONS AND WARRANTIES	  	7
	5	 	UNDERTAKINGS	  	9
	6	 	ENFORCEMENT	  	10
	7	 	FURTHER ASSURANCES AND POWER OF ATTORNEY	  	11
	8	 	TERMINATION	  	12
	9	 	ASSIGNMENT	  	14
	10	 	NOTICES	  	14
	11	 	MISCELLANEOUS	  	14
	12	 	ACCEPTANCE	  	16
	13	 	GOVERNING LAW AND JURISDICTION	  	16

  

 deed of pledge of membership rights - execution copy 

 THIS DEED OF PLEDGE OF MEMBERSHIP RIGHTS is dated 25 February 2008 and made among: 
  

	(1)	AXCAN INTERMEDIATE HOLDINGS INC. (the “Parent Borrower”), a company incorporated under the laws of the State of Delaware, the United States of America,
having its principal place of business at 22 Inverness Center Parkway, Third Floor, Birmingham, Alabama, the United States of America; 

  

	(2)	AXCAN US LLC, a limited liability company incorporated under the laws of the State of Delaware, the United States of America, having its principal place of business at 22
Inverness Center Parkway, Third Floor, Birmingham, Alabama, the United States of America; 

 each a “Pledgor”);

  

	(3)	BANK OF AMERICA, N.A., a national banking association organized and existing under the laws of the United States of America and having its principal place of business at One
Independence Center, 101 N. Tryon Street, Charlotte, NC, the United States of America, (in its capacity as administrative agent and collateral agent for the Secured Parties and/or in its capacity as sole creditor under each Parallel Debt (as defined
herein after) in both capacities, the “Pledgee”); and 

  

	(4)	AXCAN COÖPERATIEVE U.A., a cooperative society (coöperatie) incorporated and existing under Dutch law having its official seat (statutaire zetel) in
Amsterdam, the Netherlands and having its principal place of business at Fred. Roeskestraat 123 (1076 EE), Amsterdam, the Netherlands, registered with the trade register of the chamber of commerce under number 34294618 (the “Coop”).

 WHEREAS: 
  

	(A)	Reference is made to (i) the credit agreement dated as of 25 February 2008 (as amended, amended and restated, supplemented or otherwise modified from time to time, the
“Credit Agreement”), among the Parent Borrower, Axcan US Partnership 1 LP (the “Co-Borrower”, and, together with the Parent Borrower, the “Borrowers”), Axcan MidCo Inc.
(“Holdings”), Bank of America, N.A., as Administrative Agent, Swing Line Lender and L/C Issuer, and each lender from time to time party thereto (collectively, the “Lenders” and individually, a
“Lender”), pursuant to which the Lenders have made available to the Borrowers credit facilities in the maximum principal amount of $ 290,000,000, and (ii) the indenture for the Senior Secured Notes (as defined in the U.S.
Security Agreement), dated as of 25 February 2008 (as the same may be amended, modified, replaced or refinanced to the extent permitted by the Credit Agreement, the “Senior Secured Notes Indenture”), which sets forth the terms
and conditions upon which the purchasers of the Senior Secured Notes have agreed to purchase such notes from the Parent Borrower. 

  

	(B)	Pursuant to Clause 3, each Pledgor has undertaken to pay to the Pledgee, acting in its own capacity and not as representative or agent of a Loan Party, each Parallel Debt, and
consequently the Pledgee is the sole pledgee under this Deed. 

  

 deed of pledge of membership rights - execution copy 

	(C)	Each Pledgor has agreed to create a first priority disclosed right of pledge (openbaar pandrecht eerste in rang) over its Membership Rights in favour of the Pledgee as
security for the Secured Obligations. 

  

	(D)	The first priority disclosed right of pledge by each Pledgor over its Membership Rights in favour of the Pledgee as security for the Secured Obligations has been approved by all
members of the Coop on — February 2008. 

 IT IS AGREED as follows: 
  

	1	DEFINITIONS AND INTERPRETATION 

  

	1.1	Definitions 

  

	1.1.1	Capitalised words and expressions used but not defined in this Deed (including its recitals and the Schedules) shall have the same meaning as in the U.S. Security Agreement.

  

	1.1.2	In this Deed (including its recitals and the Schedules): 

 “Articles” means the articles of association of the Coop. 
 “Deed” means this deed of pledge of
membership rights. 
 “Membership Rights” means the membership (lidmaatschap) of a Pledgor in the Coop including of
any and all rights and claims (vorderingsrechten) (including but not limited to a right of recourse (regres) or subrogation (subrogatie)) whether present or future, whether actual or contingent, of each Pledgor attached thereto,
excluding in each case any 3-16 Excluded Collateral (to the same extent that 3-16 Excluded Collateral is excluded from the Collateral pursuant to Section 2.01 of the U.S. Security Agreement). 
 “Party” means a party to this Deed. 
 “Right of Pledge” means each right of pledge created by this Deed in accordance with Clause 2 (Creation of security). 
 “Secured Obligations” means: 
  

	 	(a)	the Secured Obligations as defined in the U.S. Security Agreement; and 

  

	 	(b)	each Parallel Debt. 

 “U.S. Security
Agreement” means the New York law pledge and security 

  

 deed of pledge of membership rights - execution copy 

 
agreement dated as of 25 February 2008, entered into by and between, amongst others, the Parent Borrower, Axcan US Partnership 1 LP, Holdings and
certain other subsidiaries of the Parent Borrower and Bank of America, N.A. as administrative agent. 
 “Voting Transfer
Event” means the occurrence of an Event of Default which is continuing. 
 “Voting Rights” means any and all voting
rights, other consensual rights and similar rights and powers attached to the Membership Rights. 
  

	1.2	Construction 

  

	1.2.1	Unless a contrary indication appears, any reference in this Deed (including its recitals and the Schedules) to: 

  

	 	(a)	a “Clause” or a “Schedule” shall, subject to any contrary indication, be construed as a reference to a clause or a schedule of this Deed;

  

	 	(b)	this “Deed” , includes all amendments, supplements, novations, restatements or re-enactments (without prejudice to any prohibition thereto) however fundamental and
of whatsoever nature to this Deed and includes without limitation (i) any increase or reduction in any amount available under the Credit Agreement or the other Secured Agreements (as amended, supplemented, novated, restated or re-enacted) or
any alteration of or addition to the purpose for which any such amount, or increased or reduced amount may be used, (ii) any rescheduling of the indebtedness incurred thereunder whether in isolation or in connection with any of the foregoing,
and (iii) any combination of the foregoing and the “Secured Obligations” include such amendments, supplements, novations, restatements or re-enactments (whether or not anticipated); 

  

	 	(c)	At any time other than during an Equal and Ratable Period, references herein to the Credit Agreement (including references to specific sections thereof) shall be deemed to be
references to the Credit Agreement as in effect on the date hereof (as the same has been amended, amended and restated, supplemented or otherwise modified from time to time). During any Equal and Ratable Period, references herein to the Credit
Agreement (including references to specific sections thereof) shall be deemed to be references, mutatis mutandis, to the Credit Agreement or Replacement Credit Facility (as applicable) as then in effect. 

  

	 	(d)	the “Pledgee”, any “Pledgor” or any other “Person” includes its successors in title, permitted assigns and permitted transferees;
and 

  

	 	(e)	a provision of law is a reference to that provision as amended or re-enacted. 

  

 deed of pledge of membership rights - execution copy 

	1.2.2	Clause and Schedule headings are for ease of reference only. 

  

	1.2.3	Schedules form an integral part of this Deed. 

  

	1.2.4	In this Deed (including its recitals and the Schedules), words and expressions importing the singular shall, where the context permits or requires, include the plural and vice
versa and words and expressions importing the masculine shall, where the context permits or requires, include the feminine and neuter and vice versa.  

  

	1.2.5	An Event of Default shall constitute a verzuim (as meant in Section 3:248 (1) of the Dutch Civil Code) in the proper performance of the Secured Obligations or any
part thereof, without any dun (aanmaning), summons (sommatie) or notice of default (ingebrekestelling) being sent or required. 

  

	2	CREATION OF SECURITY 

  

	2.1	Undertaking 

 Each Pledgor agrees with the Pledgee
and undertakes to create or, as the case may be, to create in advance (bij voorbaat) a first priority disclosed right of pledge (openbaar pandrecht eerste in rang) over each of its Membership Rights as security for the Secured
Obligations. 
  

	2.2	Right of Pledge 

 Each Pledgor grants to the
Pledgee: 
  

	 	(a)	a first priority disclosed right of pledge (openbaar pandrecht eerste in rang) over each of its Membership Rights; and 

  

	 	(b)	to the extent the Membership Rights consist of future Membership Rights, a first priority disclosed right of pledge openbaar pandrecht eerste in rang) in advance (bij
voorbaat) over each of its future Membership Rights, 

 as security for the Secured Obligations. 
  

	2.3	Perfection 

  

	2.3.1	The Coop: 

  

	 	(a)	acknowledges to be notified of the Right of Pledge and undertakes to register the Right of Pledge in its members’ register; 

  

	 	(b)	undertakes that promptly after each Pledgor has acquired Membership Rights it shall register the Right of Pledge in its members’ register; 

  

 deed of pledge of membership rights - execution copy 

	 	(c)	undertakes to provide the Pledgee promptly after the execution of this Deed and promptly after each acquisition of Membership Rights by each Pledgor with a copy of the relevant
entry in its members’ register; 

  

	 	(d)	to the extent possible under Dutch law and with the knowledge of each Pledgor, waives (and shall waive at the Pledgee’s first request) any right that may impede the exercise by
the Pledgee of the Right of Pledge and the other rights conferred under this Deed; and 

  

	 	(e)	undertakes not to propose or effect such acts as set forth in Clause 5.4. 

  

	2.3.2	The Pledgee is entitled: 

  

	 	(a)	to present this Deed and any other document pursuant to this Deed for registration to any office, registrar or governmental body (including the Dutch tax authorities) in any
jurisdiction; and 

  

	 	(b)	subject to Clause 2.3.4, to serve any notice to a Party or any other Person, 

 as the Pledgee deems necessary or desirable to protect its interests. 
  

	2.3.3	In accordance with Section 3:246 (1) of the Dutch Civil Code, if an Event of Default shall have occurred which is continuing, only the Pledgee is entitled to collect and
receive payment of the Membership Rights which are subject to a Right of Pledge and to exercise all rights of a Pledgor vis-à-vis the Coop. Without prejudice to its entitlement to collect and receive payment and to exercise its rights,
the Pledgee authorises the relevant Pledgor to collect and receive payment from the Coop. 

  

	2.3.4	The authorisation granted by the Pledgee to the relevant Pledgor pursuant to Clause 2.3.3 may be terminated by the Pledgee upon the occurrence of an Event of Default which is
continuing by giving written notice thereof to the relevant Pledgor. 

  

	2.4	General 

  

	2.4.1	Each Right of Pledge includes all accessory rights (afhankelijke rechten) and all ancillary rights (nevenrechten) attached to the Membership Rights.

  

	2.4.2	To the extent that the Membership Rights are (or shall be) subject to a right of pledge or other encumbrance taking priority over a Right of Pledge, nevertheless that Right of
Pledge will have been (or will be) created with the highest possible rank available at that time. Until notification of a Right of Pledge in accordance with Clause 2.3 (Perfection) and provided that this Deed is registered with the Dutch tax
authorities, that Right of Pledge constitutes an undisclosed right of pledge (stil pandrecht) over the Membership Rights. 

  

 deed of pledge of membership rights - execution copy 

	2.5	Each Right of Pledge is in addition to, and not in any way prejudiced by any other security (whether by contract or statute) now or subsequently held by the Pledgee. The rights of
the Pledgee under this Deed are in addition to and not in lieu of those provided by law. 

  

	2.6	Voting rights 

  

	2.6.1	The Voting Rights are transferred by each Pledgor to the Pledgee under the condition precedent (opschortende voorwaarde) of the occurrence of a Voting Transfer Event,
provided that 10 days’ prior written notice from the Pledgee to the Pledgors and the Coop stating that the Pledgee shall exercise the Voting Rights has been given. 

  

	2.6.2	Upon the occurrence of a Voting Transfer Event, provided that 10 days’ prior written notice from the Pledgee to the Pledgors and the Coop stating that the Pledgee shall
exercise the Voting Rights has been given, the Pledgee shall have the sole and exclusive right and authority to exercise such Voting Rights and shall be entitled to exercise or refrain from exercising such rights in such manner as the Pledgee may in
its absolute discretion deem fit provided that no such exercise (or such abstention) may violate or be inconsistent with the terms and conditions of this Deed, the Credit Agreement or any other Secured Agreement. 

  

	3	PARALLEL DEBT 

 Each Pledgor irrevocably and
unconditionally undertakes (and to the extent necessary undertakes in advance (bij voorbaat)) to pay to the Pledgee amounts equal to any amounts owing from time to time by that Pledgor to any Secured Party under any Secured Agreement as and
when those amounts are due. 
 Each Pledgor and the Pledgee (on behalf of itself and the other Secured Parties) acknowledge that the
obligations of each Pledgor under this Clause 3 are several and are separate and independent (eigen zelfstandige verplichtingen) from, and shall not in any way limit or affect, the corresponding obligations of that Pledgor to any Secured
Party under any Secured Agreement (its “Corresponding Debt”) nor shall the amounts for which each Pledgor is liable under Clause 3 (its “Parallel Debt”) be limited or affected in any way by its Corresponding Debt
provided that: 
  

	 	(a)	the Parallel Debt of each Pledgor shall be decreased to the extent that its Corresponding Debt has been irrevocably paid or (in the case of guarantee obligations) discharged; and

  

	 	(b)	the Corresponding Debt of each Pledgor shall be decreased to the extent that its Parallel Debt has been irrevocably paid or (in the case of guarantee obligations) discharged; and

  

	 	(c)	the amount of the Parallel Debt of each Pledgor shall at all times be equal to the amount of its Corresponding Debt. 

  

 deed of pledge of membership rights - execution copy 

 
For the purpose of this Clause 3, the Pledgee acts in its own name and on behalf of itself and not as agent, representative or trustee of any other Secured
Party, and its claims in respect of each Parallel Debt shall not be held on trust. 
 All monies received or recovered by the Pledgee pursuant
to this Clause 3, and all amounts received or recovered by the Pledgee from or by the enforcement of any Liens granted to secure each Parallel Debt, shall be applied in accordance with the terms of the relevant Secured Agreements. 
 Without limiting or affecting the Pledgee’s rights against the Pledgors (whether under this Clause 3 or under any other provision of the Secured
Agreements), each Pledgor acknowledges that: 
  

	 	(d)	nothing in this Clause 3 shall impose any obligation on the Pledgee to advance any sum to any Pledgor; and 

  

	 	(e)	for the purpose of any vote taken under any Secured Agreement, the Pledgee shall not be regarded as having any participation or commitment other than those which it has in its
capacity as a Lender. 

 For the avoidance of doubt the Parallel Debt of each Pledgor will become due and payable
(opeisbaar) at the same time its Corresponding Debt becomes due and payable; and 
 The Pledgee (on behalf of itself and the other
Secured Parties) and each Pledgor confirms that, in accordance with this Clause 3 a claim of the Administrative Agent against a Pledgor in respect of a Parallel Debt does not constitute common property (een gemeenschap) within the meaning of
Section 3:166 Dutch Civil Code and that the provisions relating to such common property shall not apply. If, however, it shall be held that such claim of the Administrative Agent does constitute common property and such provisions do apply, the
parties to this Deed agree that this Deed shall constitute the administration agreement (beheersregeling) within the meaning of (and for the purposes of) Section 3:168 Dutch Civil Code. 
  

	4	REPRESENTATIONS AND WARRANTIES 

  

	4.1	General 

  

	4.1.1	Each Pledgor makes the representations and warranties in this Clause 4 in respect of itself to the Pledgee on the date of this Deed. 

  

	4.1.2	The representations and warranties in this Clause 4 in respect of the Membership Rights only refer to the Membership Rights owned by a Pledgor on the date the representations or
warranties are made. 

  

 deed of pledge of membership rights - execution copy 

	4.2	Corporate status, power and authority 

 It is duly
incorporated, validly existing and has the power (beschikkingsbevoegdheid) to enter into, perform and deliver, and has taken all necessary action to authorise its entry into, performance and delivery of, this Deed and the transactions
contemplated by this Deed and to create each Right of Pledge. 
  

	4.3	Legal validity 

 This deed is its legally binding,
valid and enforceable obligation 
  

	4.4	Ranking 

 Each Right of Pledge is a first ranking
right of pledge (pandrecht eerste in rang). 
  

	4.5	Membership Rights 

  

	4.5.1	It is the sole legal and beneficial owner of its Membership Rights. 

  

	4.5.2	The Articles are in full force and effect on the date hereof and no action has been taken or is pending to amend, restate, supplement or novate the Articles.

  

	4.5.3	Subject to Liens permitted by Section 7.01 of the Credit Agreement, the Membership Rights: 

  

	 	(a)	have, save for the relevant Right of Pledge, not been transferred, assigned, pledged, made subject to a limited right (beperkt recht) or otherwise encumbered (in advance
(bij voorbaat)) to any Person; 

  

	 	(b)	are not subject to any attachment (beslag); 

  

	 	(c)	are capable of being transferred, assigned and pledged; and 

  

	 	(d)	are not subject to any option or similar right, 

 and no
Pledgor has agreed to grant any right or to do such acts as set forth in this Clause 4.5.3 in respect of the Membership Rights. 
  

	4.6	Information 

 It has provided the Pledgee with all
information and documentation regarding the Membership Rights, which it understands or should be aware is important to the Pledgee 
  

 deed of pledge of membership rights - execution copy 

	5	UNDERTAKINGS 

  

	5.1	General 

 The undertakings in this clause 4 remain
in force from the date of this Deed until each Right of Pledge is terminated in respect of all Pledgors in accordance with Clause 8 (Termination). 
  

	5.2	Membership Rights 

 Unless explicitly permitted
under the Credit Agreement, no Pledgor shall: 
  

	 	(a)	transfer, assign, pledge, make subject to a limited right (beperkt recht) or otherwise encumber the Membership Rights; 

  

	 	(b)	release (kwijtschelden) or waive (afstand doen van) the Membership Rights; 

  

	 	(c)	waive any accessory rights (afhankelijke rechten) or ancillary rights (nevenrechten) attached to the Membership Rights; 

  

	 	(d)	agree with a court composition or an out-of-court composition (gerechtelijk of buitengerechtelijk akkoord) or enter into any settlement agreement in respect of the
Membership Rights; or 

  

	 	(e)	perform any act which adversely affects or may adversely affect the Membership Rights or any Right of Pledge, 

 without the prior written consent of the Pledgee. 
  

	5.3	Information 

  

	5.3.1	A Pledgor shall promptly provide notice in writing, at its own costs, of the existence of this Deed and each Right of Pledge to any relevant Person (including without limitation,
the court process server (deurwaarder), the bankruptcy trustee (curator), the administrator (bewindvoerder) or similar officer in any jurisdiction) and shall promptly send to the Pledgee a copy of the relevant correspondence and
the underlying documentation. 

  

	5.3.2	Each Pledgor shall at the Pledgee’s first request provide the Pledgee with all information and with copies of all relevant documentation relating to the Membership Rights and
allow the Pledgee to inspect its administrative records in respect of the Membership Rights. 

  

	5.4	Voting rights 

  

	5.4.1	 Except as permitted under the Credit Agreement, no Pledgor shall, without the prior written consent of the Pledgee, exercise its Voting Rights that may materially
and adversely affect the rights and remedies of the Pledgee under this Deed, the Credit Agreement or any other Secured Agreement, or if such exercise may result in a resolution to consent or to ratify: (a) an amendment of the Articles to the
extent such amendment adversely affect the interest of the Pledgee under this Deed or 

  

 deed of pledge of membership rights - execution copy 

	 	 
the other Secured Agreement, (b) a filing of a request to declare the Coop bankrupt (failliet) or a filing of a request for a similar proceeding
in any jurisdiction, (c) a filing by the Coop of a request to be granted a suspension of payments (surséance van betaling) or a filing by the Coop of a request for a similar proceeding in any jurisdiction, (d) the
liquidation or dissolution of the Coop or the Coop ceasing to carry on the whole or a part of its business, (e) the distribution of any income, profit or gain in respect of any membership rights, (f) an issuance or cancellation of
membership rights, (g) an admission of a member to the Coop, (h) an acquisition by the Coop of membership rights or (i) a granting of rights to subscribe for membership rights. 

  

	6	ENFORCEMENT 

  

	6.1	Enforcement 

  

	6.1.1	Upon the occurrence of an Event of Default which is continuing, the Pledgee shall have the right to enforce any Right of Pledge in accordance with Dutch law and any other applicable
law and may take all (legal) steps and measures which it deems necessary or desirable and each Pledgor shall co-operate with the Pledgee in any way which the Pledgee reasonably deems necessary or desirable for the enforcement of that Right of
Pledge. 

  

	6.1.2	Upon the occurrence of an Event of Default, the Pledgee shall have the right to enter into court compositions or out-of-court compositions (gerechtelijke of
buitengerechtelijke akkoorden) and to cast a vote in connection with such compositions or to enter into any settlement agreement regarding the Membership Rights with the Coop or any other Person. 

  

	6.2	Enforcement waivers 

  

	6.2.1	The Pledgee shall not be obliged to give notice of a sale of the Membership Rights to a Pledgor, the Coop, holders of a limited right (beperkt recht) or Persons who
have made an attachment (beslag) on the Membership Rights, as required by Sections 3:249 and 3:252 of the Dutch Civil Code. 

  

	6.2.2	Each Pledgor waives its rights to make a request to the court: 

  

	 	(a)	as referred to in Section 3:251 (1) of the Dutch Civil Code to determine that the Membership Rights shall be sold in a manner deviating from the provisions of
Section 3:250 of the Dutch Civil Code; and 

  

	 	(b)	as referred to in Section 3:246 (4) of the Dutch Civil Code to collect and receive payment of the Membership Rights after such authorisation has been terminated in
accordance with Clause 2.3.4 (Perfection). 

  

	6.2.3	Each Pledgor waives its rights to demand that the Pledgee: 

  

	 	(a)	shall first enforce any security granted by any other Person, pursuant to Section 3:234 of the Dutch Civil Code; or 

  

 deed of pledge of membership rights - execution copy 

	 	(b)	shall first proceed against or claim payment from any other Person or enforce any guarantee, before enforcing any Right of Pledge. 

 Each Pledgor waives its rights under Sections 3:233 (2) and 6:139 of the Dutch Civil Code. 
  

	6.2.4	Each Pledgor waives its rights to set-off (verrekenen) its claims (if any) against the Pledgee under or in connection with this Deed against the Secured Obligations.

  

	6.3	Application of monies 

 Subject to the mandatory
provisions of Dutch law on enforcement, all monies received or realised by the Pledgee in connection with the enforcement of any Right of Pledge shall be applied by the Pledgee in accordance with Section 4.02 of the U.S. Security Agreement.

  

	7	FURTHER ASSURANCES AND POWER OF ATTORNEY 

  

	7.1	Further assurances 

  

	7.1.1	If no valid right of pledge is created pursuant to this Deed in respect of any Membership Right, each Pledgor irrevocably and unconditionally undertakes to pledge to the Pledgee
such Membership Right as soon as it becomes available for pledging, by way of supplementary agreements, supplemental deeds or other instruments on the same (or similar) terms of this Deed. 

  

	7.1.2	Each Pledgor further undertakes to execute any instrument, provide such assurances and do all acts and things as may be necessary or desirable for: 

  

	 	(a)	perfecting or protecting the security created (or intended to be created) by this Deed; 

  

	 	(b)	preserving or protecting any of the rights of the Pledgee under this Deed; 

  

	 	(c)	preserving or protecting the Pledgee’s interest in the Membership Rights; 

  

	 	(d)	ensuring that any Right of Pledge and the undertakings and obligations of each Pledgor under this Deed shall inure to the benefit of any successor, transferee or assignee of the
Pledgee; 

  

	 	(e)	facilitating the collection, appropriation or realisation of the Membership Rights or any part thereof in the manner contemplated by this Deed; or 

  

 deed of pledge of membership rights - execution copy 

	 	(f)	exercising any power, authority or discretion vested in the Pledgee under this Deed. 

  

	7.2	Power of attorney 

  

	7.2.1	Each Pledgor irrevocably and unconditionally appoints the Pledgee as its attorney (gevolmachtigde) for as long as any of the Secured Obligations are outstanding for the
purposes of: 

  

	 	(a)	doing in its name all acts and executing, signing and (if required) registering in its name all documents which the Pledgors themselves could do, execute, sign or register in
relation to the Membership Rights; and 

  

	 	(b)	executing, signing, perfecting, doing and (if required) registering every such further document, act or thing as is referred to in this Clause 7. 

  

	7.2.2	It is expressly agreed that the appointment under Clause 7.2.1 will only be exercised by the Pledgee in case of an Event of Default which is continuing or if a Pledgor has not acted
in accordance with the instructions of the Pledgee and is given with full power of substitution and also applies to any situation where the Pledgee acts as a Pledgor’s counterparty (Selbsteintritt) within the meaning of Section 3:68
of the Dutch Civil Code or as a representative of a Pledgor’s counterparty. 

  

	8	TERMINATION 

  

	8.1	Continuing 

  

	8.1.1	Each Right of Pledge shall remain in full force and effect, unless terminated pursuant to this Clause 8 (Termination). 

  

	8.1.2	Each Right of Pledge shall terminate with respect to all Credit Facilities Obligations and any Liens arising therefrom that secure the Credit Facilities Obligations shall be
automatically released upon the termination of each Equal and Ratable Period. 

  

	8.1.3	Each Right of Pledge shall terminate with respect to any Other Secured Obligations and any Liens arising therefrom that secure such Other Secured Obligations shall be automatically
released when the outstanding amount of such Other Secured Obligations (other than contingent indemnification obligations not yet accrued and payable) have been paid in full or defeased or discharged in accordance with their terms.

  

	8.1.4	 The Pledgor shall automatically be released from (i) during an Equal and Ratable Period, its obligations hereunder as provided in Section 9.11 (excluding
Section 9.11(a)(i)) of, or otherwise in accordance with, the Credit Agreement or equivalent provision of, or otherwise in accordance with, any Replacement Credit Facility; provided that the Credit Facility Lenders shall have consented to such
transaction 

  

 deed of pledge of membership rights - execution copy 

	 	 
to the extent required by the Credit Agreement (or Replacement Credit Facility) and (ii) its obligations hereunder with respect to any Other Secured
Obligations as provided by, the terms of the applicable Other Secured Agreement; provided that any consents required by the terms of the Other Secured Agreement shall have been obtained. 

  

	8.1.5	Upon any sale or other transfer by the Pledgor of any of its Membership Rights that is permitted under (i) during an Equal and Ratable Period, the Credit Agreement or any
Replacement Credit Facility and (ii) at any time other than during an Equal and Ratable Period, the Other Secured Agreements, the security interest of such Pledgor in such Membership Rights (but not in the Proceeds thereof) shall be
automatically released to the extent provided in the applicable Secured Agreement. During an Equal and Ratable Period, upon the effectiveness of any written consent to the release of the security interest granted hereby in any of the Membership
Rights pursuant to Section 9.11 of the Credit Agreement or equivalent provision of any Replacement Credit Facility, such security interest in such Membership Rights (but not in the proceeds thereof) shall be automatically released with respect
to all Secured Obligations. Upon the effectiveness of any written consent to the release of the security interest granted hereby in any of the Membership Rights pursuant to any Other Secured Agreement, such security interest in such collateral shall
be released solely with respect to the applicable Other Secured Obligations. 

  

	8.1.6	Notwithstanding anything to the contrary set forth in this Deed, no release of a Pledgor from its obligations hereunder with respect to the Other Secured Obligations or of a
Security Interest or security interest granted hereunder with respect to the Other Secured Obligations shall occur pursuant to Clauses 8.1.4 and 8.1.5 if the transactions or consents that would otherwise give rise to such release shall have occurred
substantially concurrently with or in contemplation of the end of an Equal and Ratable Period, unless such release is expressly permitted pursuant to the Other Secured Agreements or approved by the holders of the Secured Obligations arising
thereunder. 

  

	8.1.7	The Pledgee irrevocably and unconditionally undertakes to execute any instrument and to provide such assurances and do all acts and things as may be necessary or desirable to effect
any termination, release and discharge pursuant to this Clause. 

  

	8.1.8	In case a Right of Pledge is terminated, the Pledgee shall at the request and expense of the relevant Pledgor provide written evidence to the relevant Pledgor to that effect.

  

	8.2	Termination by Pledgee 

 Subject to the terms of the
Credit Agreement, the Pledgee is entitled to: 
  

	 	(a)	terminate by notice (opzeggen); or 

  

	 	(b)	waive (afstand doen),  

  

 deed of pledge of membership rights - execution copy 

 a Right of Pledge, in respect of all or part of the Membership Rights and all or part of the Secured
Obligations and in respect of any or all of the Pledgors. Each Pledgor agrees in advance to any waiver (afstand van recht) granted by the Pledgee under this Clause 8.2. 
  

	9	ASSIGNMENT 

  

	9.1	No assignment – Pledgors 

 Except as permitted
under the Credit Agreement, no Pledgor shall assign or transfer any of its rights and obligations under this Deed without the prior written consent of the Pledgee. 
  

	9.2	Assignment – Pledgee 

 The Pledgee may
transfer, assign or pledge any of its rights and obligations under this Deed in accordance with the Credit Agreement and each Pledgor, to the extent legally required, irrevocably cooperates or consents in advance (verleent bij voorbaat
medewerking of geeft bij voorbaat toestemming) to such transfer, assignment or pledge. If the Pledgee transfers, assigns or pledges its rights under the Secured Obligations (or a part thereof), each Pledgor and the Pledgee agree that each Right
of Pledge shall follow pro rata parte the transferred, assigned or pledged rights under the Secured Obligations (as an ancillary right (nevenrecht) to the relevant transferee, assignee or pledgee). 
  

	10	NOTICES 

 Any communication to be made under or in
connection with this Deed shall be made in accordance with the relevant provisions of the Credit Agreement. 
  

	11	MISCELLANEOUS 

  

	11.1	Costs 

 All costs, charges, expenses and taxes shall
be payable by the Pledgors in accordance with the relevant provisions of the Credit Agreement. 
  

	11.2	Evidence of debt 

 As to the existence and
composition of the Secured Obligations, a written statement by the Pledgee made in accordance with its books shall, save for manifest error, constitute conclusive evidence (dwingend bewijs), it being understood that in the event of a
disagreement with respect thereto, the Pledgee shall be authorised to exercise its right of enforcement under this Deed. 
  

 deed of pledge of membership rights - execution copy 

	11.3	Severability 

  

	11.3.1	If a provision of this Deed is or becomes illegal, invalid or unenforceable in any jurisdiction that shall not affect: 

  

	 	(a)	the validity or enforceability in that jurisdiction of any other provision of this Deed; or 

  

	 	(b)	the validity or enforceability in other jurisdictions of that or any other provision of this Deed. 

  

	11.3.2	Each Pledgor and the Pledgee agree that they will negotiate in good faith to replace any provision of this Deed which may be held unenforceable with a provision which is enforceable
and which is as similar as possible in substance to the unenforceable provision. 

  

	11.4	No rescission 

 Each Pledgor waives, to the fullest
extent permitted by law, its rights: 
  

	 	(a)	to dissolve (ontbinden) this Deed in case of failure in the performance of one or more of the Pledgee’s obligations pursuant to Section 6:262 of the Dutch Civil
Code or on any other ground; 

  

	 	(b)	to suspend (opschorten) any of its obligations under this Deed pursuant to Section 6:52 of the Dutch Civil Code or on any other ground; and 

  

	 	(c)	to nullify (vernietigen) this Deed pursuant to Section 6:228 of the Dutch Civil Code or on any other ground. 

  

	11.5	No waiver 

 No delay or omission by the Pledgee in
the exercise of any power or right under this Deed will impair such power or right or be construed as a waiver thereof or of the event giving rise to such power of right and no waiver of any past event shall be construed to be a waiver of any power
or right accruing to this Deed by reason of any future event. 
  

	11.6	Amendment and embodiment 

 This Deed shall not be
amended, modified or rescinded except in writing when duly signed by authorised signatories of each Pledgor and the Pledgee. Any amendment, addendum and appendix so signed shall constitute part of this Deed. 
  

	11.7	Counterparts 

 This Deed may be executed in any
number of counterparts, all of which taken together shall constitute one and the same instrument. 
  

 deed of pledge of membership rights - execution copy 

	12	ACCEPTANCE 

 The Pledgee accepts each Right of
Pledge and all stipulations, covenants, undertakings, waivers, authorities and powers pursuant to this Deed. 
  

	13	GOVERNING LAW AND JURISDICTION 

  

	13.1	Governing law 

 This Deed shall be governed by Dutch
law. 
  

	13.2	Jurisdiction 

  

	13.2.1	The court (rechtbank) of Amsterdam, the Netherlands has exclusive jurisdiction to settle any dispute arising out of or in connection with this Deed (including a dispute
regarding the existence, validity or termination of this Deed) (a “Dispute”). 

  

	13.2.2	Each Party agrees that the court (rechtbank) of Amsterdam, the Netherlands is the most appropriate and convenient court to settle Disputes and accordingly no Party will argue
to the contrary. 

  

	13.2.3	This Clause 13.2 is for the benefit of the Pledgee only. As a result, the Pledgee shall not be prevented from taking proceedings relating to a Dispute in any other courts with
jurisdiction. To the extent allowed by law, the Pledgee may take concurrent proceedings in any number of jurisdictions. 

  

	13.3	Acceptance governing law power of attorney 

 If a
Party is represented by an attorney in connection with the execution of this Deed or any agreement or document pursuant this Deed: 
  

	 	(a)	the existence and extent of the authority of; and 

  

	 	(b)	the effects of the exercise or purported exercise of that authority by, 

 that attorney is governed by the law designated in the power of attorney pursuant to which that attorney is appointed and such choice of law is accepted by the other Parties. 
 IN WITNESS WHEREOF this Deed was signed on the date first written above. 
 [SIGNATURE PAGE TO FOLLOW] 
  

 deed of pledge of membership rights - execution copy 

 SIGNATURE PAGE 
  

			
	Pledgors
	
	AXCAN INTERMEDIATE HOLDINGS INC.
		
	By:	 	 /s/ Steve Gannon

	Name:	 	Steve Gannon
	Title:	 	Senior Vice President – Finance, Chief Financial Officer and Treasurer
	
	AXCAN US LLC
		
	By:	 	Axcan Intermediate Holdings Inc.,
		 	its Sole Member
		
	By:	 	 /s/ Steve Gannon

	Name:	 	Steve Gannon
	Title:	 	Senior Vice President – Finance, Chief Financial Officer and Treasurer

  

							
	Pledgee	 		 	
			
	BANK OF AMERICA, N.A.	 		 	
				
	By:	 	 /s/ Mollie S. Canup
	 		 	
	Name:	 	Mollie S. Canup	 		 	
	Title:	 	Vice President	 		 	

  

			
	Coop
	
	AXCAN COÖPERATIEVE U.A.
		
	By:	 	 /s/ David Mims

	Name:	 	David Mims
	Title:	 	Attorney-in-Writing

  

 Deed of Pledge of Membership Rights

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