Document:

Amendment dated February 3, 2009 to Amended Employment Agreement

 EXHIBIT 10.20 
 AMENDMENT TO EMPLOYMENT AGREEMENT 
 THIS AMENDMENT TO
EMPLOYMENT AGREEMENT (the “Amendment”) is made and entered into as of February 3, 2009 by and between TorreyPines Therapeutics, Inc. (the
“Parent”), Parent’s subsidiary, TPTX, Inc. (“TPTX”) and CRAIG JOHNSON (“Executive”). As used in this Amendment,
references to the “Company” shall include the Parent and TPTX, as appropriate. Capitalized terms used but not defined herein shall have the meaning assigned to them in the Agreement (as defined below). 
 RECITALS 
 WHEREAS, the Company and Executive previously entered into that certain Amended and Restated Employment Agreement dated as of November 12, 2008 (the “Agreement”); and

 WHEREAS, the parties desires to amend the Agreement as set forth below. 
 NOW, THEREFORE, in consideration for the foregoing premises and the mutual covenants and conditions set forth below,
and for other good and valuable consideration, the receipt of which is hereby acknowledged, the parties to this Amendment hereby agree as follows: 
 AMENDMENT 
 1. Section 4.4.2.1 of the Agreement is hereby amended and restated in its entirety to
read as follows: 
 “The Company shall continue to pay the Executive’s base salary during the period following the
termination or resignation of the Executive for a period equal to tweleve (12) months (the “Compensation Severance Period”). Such severance payments shall be subject to standard deductions and withholdings and paid in
accordance with the Company’s regular payroll policies and practices. For purposes of calculating the amount to be paid pursuant this Section 4.4.2.1, the Company shall use the Executive’s base salary in effect on the date of such
termination or resignation, but determined prior to any reduction in base salary that would permit the Executive to voluntarily resign for Good Reason pursuant to Section 4.5.3(iii).” 
 2. Except as modified by this Amendment, the Agreement shall remain in full force and effect in accordance with its terms. 
 3. This Amendment may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument. 
  

 1. 

 IN WITNESS WHEREOF, the parties hereto have executed
this AMENDMENT TO EMPLOYMENT AGREEMENT as of the date set forth in the first paragraph hereof. 
  

									
	TORREYPINES THERAPEUTICS, INC.:	 		 	CRAIG JOHNSON
					
	By: 	 	/s/ Evelyn Graham	 		 	By: 	 	/s/ Craig Johnson
		 	Evelyn Graham	 		 		 	Craig Johnson
		 	Chief Executive Officer	 		 		 	Vice President, Finance and Chief Financial Officer

 [SIGNATURE PAGE TO AMENDMENT TO EMPLOYMENT AGREEMENT]Amended and Restated Employment Agreement

 EXHIBIT 10.21 
 AMENDED AND RESTATED EMPLOYMENT AGREEMENT 
 This AMENDED AND
RESTATED EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of November 12, 2008 (the “Effective
Date”), by and between TorreyPines Therapeutics, Inc. (the “Parent”) Parent’s subsidiary, TPTX, Inc. (“TPTX”) and Paul Schneider (the
“Executive”). As used in this Agreement, references to the “Company” shall include the Parent and TPTX, as appropriate. This Agreement shall replace and supersede that certain Employment
Agreement between Executive and the Company entered into effective as of February 1, 2007 (the “Prior Agreement”). The Company and the Executive are hereinafter collectively referred to as the
“Parties,” and individually referred to as a “Party.” 
 RECITALS 
 A. The Company and Executive previously entered into the Prior Employment Agreement and
desire to amend and restate the Prior Agreement in its entirety as set forth herein, effective as of the Effective Date, in order to clarify the application of Section 409A of the Internal Revenue Code (the “Code”) to
the benefits provided to Executive under the Prior Agreement. 
 B. The Company desires to retain the Executive’s experience, skills,
abilities, background and knowledge and is willing to engage the Executive’s services on the terms and conditions set forth in this Agreement. 
 C. The Executive desires to be in the employ of the Company and is willing to accept such employment on the terms and conditions set forth in this Agreement. 
 D. The Parties contemplate that Executive will be an employee of both the Parent and TPTX, and all amounts required to be paid to Executive
pursuant to this Agreement will be paid by TPTX. 
 AGREEMENT 
 In consideration of the foregoing Recitals and the mutual promises and covenants herein contained, and for other good and valuable consideration, the
Parties, intending to be legally bound, agree as follows: 
  

	 	1.	EMPLOYMENT. 

 1.1 Title. The Executive shall serve as the Parent’s Vice President and General Counsel and shall serve in such other capacities as the Company may from time to time prescribe. The Executive shall report solely and
directly to the Company’s Chief Executive Officer. 
  

 1. 

 1.2 Duties. The Executive shall perform all services and actions necessary
or advisable to conduct the business of the Company and which are normally associated with the position(s) the Executive holds in a corporation of the size and nature of the Company. 
 1.3 Location. Except as otherwise specifically permitted by the Parent’s Board of Directors (the
“Board”), the Executive shall perform the services required pursuant to this Agreement at the Company’s offices located in San Diego, California; provided, however, that the Company may require the Executive to travel
temporarily to other locations in connection with the Company’s business. 
  

	 	2.	LOYAL AND CONSCIENTIOUS PERFORMANCE; NONCOMPETITION. 

 2.1 Loyalty. Except as otherwise specifically permitted by the Board, during the Executive’s employment with the Company, the
Executive shall devote the Executive’s full business energies, interest, abilities and productive time to the proper and efficient performance of the Executive’s duties under this Agreement; provided, however, that Executive may
devote a reasonable amount of time and energies for personal investment and civic and charitable duties. 
  

	 	3.	COMPENSATION OF THE EXECUTIVE. 

 3.1 Base Salary. The Company shall pay the Executive a base salary of Two Hundred Seventeen Thousand Seven Hundred Dollars
($217,700) per year, payable in regular periodic payments in accordance with Company policy. Such base salary shall be prorated for any partial year of employment on the basis of a 365-day fiscal year. 
 3.2 Annual Incentive Bonus. In addition to the Executive’s base
salary, the Executive will be eligible to receive an annual performance bonus. The bonus amount Executive may receive ̧ if any, shall be based upon the Executive’s and the Company’s performance as measured against agreed-upon targets
during the previous year as evaluated by the Board in its sole and absolute discretion. The bonus amount payable for performance that meets the targets shall be a percentage of the Executive’s annual base salary (the “Target Bonus
Amount”). For 2007, the Executive’s Target Bonus Amount shall be twenty-five percent (25%) of the Executive’s annual base salary. Annual performance bonus pay will vary according to the Executive’s and the
Company’s performance against the targets and will be capped at one hundred fifty percent (150%) of the Target Bonus Amount. In the event the Company and the Executive do not agree upon the performance targets, the Board shall establish
the applicable performance targets in its sole and absolute discretion. Subject to the conditions contained herein, the Company will pay any portion of any bonus earned hereunder between January 1st and March 15th of the calendar year following the year for which the bonus
is earned. 
 3.3 Changes to Compensation. The Executive’s compensation shall be reviewed from time to time
by the Board or the Compensation Committee thereof as it deems appropriate and may be increased at any time by the Board or the Compensation Committee thereof or may be reduced only upon mutual written agreement between the Executive and the Board
or the Compensation Committee thereof. 
  

 2. 

 3.4 Employment Taxes. All of the Executive’s compensation (in any form) shall
be subject to all required withholding taxes, employment taxes and other deductions required by law. 
 3.5
Benefits. The Executive shall, in accordance with Company policy and the terms of the applicable plan documents, be eligible to participate in benefits under any benefit plan or arrangement which may be in effect from time to time and
made available to the Company’s employees. In addition, the Executive shall be eligible for paid vacation, in accordance with Company policy as in effect from time to time. 
 3.6 Equity Compensation. The Compensation Committee of the Board will periodically evaluate the equity position of Executive and
determine changes, if any, at its annual meeting addressing executive compensation in general. 
  

	 	4.	TERMINATION. 

 4.1
Termination By the Company. The Executive’s employment with the Company may be terminated under the following conditions: 
 4.1.1 Termination for Death or Disability. The Executive’s employment with the Company shall terminate effective upon the date of the Executive’s death or Complete Disability (as defined below). 
 4.1.2 Termination by the Company For Cause. The Company may terminate the Executive’s employment under this Agreement
for Cause (as defined below). A notice of termination given pursuant to this Section 4.1.2 shall effect termination as of the date specified, or, in the event no such date is specified, on the date upon which the notice is given. 
 4.1.3 Termination by the Company For Any Reason Other Than Cause. The Executive’s employment by the Company shall be “at
will.” The Company may terminate the Executive’s employment under this Agreement at any time, for any or no reason and with or without cause or advance notice. This is the full and complete agreement between the Executive and the Company
on this term. Although the Executive’s duties, title, compensation and benefits may change, the “at will” nature of the Executive’s employment relationship with the Company may only be modified in an express written agreement
signed by the Executive and the Board. 
 4.2 Termination by Mutual Agreement of the Parties. The
Executive’s employment pursuant to this Agreement may be terminated at any time upon the mutual written agreement of the Parties. Any such termination of employment shall have the consequences specified in such writing. 
 4.3 Termination by the Executive. The Executive’s employment by the Company shall be “at will.” The Executive shall
have the right to resign or terminate the Executive’s employment at any time, with or without cause, notice or Good Reason. 
  

 3. 

 4.4 Compensation Upon Termination. 
 4.4.1 Termination With Cause or Without Good Reason; Termination Due to Death or Complete Disability. Upon
Executive’s termination with Cause or resignation without Good Reason, the Company shall pay the Executive’s base salary and any accrued and unused vacation benefits earned through the date of such termination or resignation, less standard
deductions and withholdings. If the Executive’s employment shall be terminated by death or Complete Disability as provided in Section 4.5.1, the Company shall pay to the Executive, or to the Executive’s heirs, the Executive’s
base salary and accrued and unused vacation benefits earned through the date of termination at the rate in effect at the time of termination, less standard deductions and withholdings. Except as expressly provided herein, the Company shall
thereafter have no further obligations to the Executive under this Agreement. 
 4.4.2 Severance Payments. In
addition to the payments provided in Section 4.4.1, if the Executive’s employment is terminated at any time by the Company without Cause, or if the Executive resigns for Good Reason within the period commencing three (3) months before
and ending twelve (12) months following a Change in Control (as defined below), then the Company shall provide the following benefits: 
 4.4.2.1 The Company shall continue to pay the Executive’s base salary during the period following the termination or resignation of the Executive for a period equal to six (6) months (the
“Compensation Severance Period”). Such severance payments shall be subject to standard deductions and withholdings and paid in accordance with the Company’s regular payroll policies and practices. For purposes of
calculating the amount to be paid pursuant this Section 4.4.2.1, the Company shall use the Executive’s base compensation in effect on the date of such termination or resignation, but determined prior to any reduction in base salary that
would permit the Executive to voluntarily resign for Good Reason pursuant to Section 4.5.3(iii). 
 4.4.2.2 Each month during the Compensation Severance Period, the Company
shall pay the Executive an amount equal to one-twelfth (1/12th) of the greater of (i) the average of the three annual bonuses paid to the
Executive by the Company prior to the date of termination or resignation, (ii) the last annual bonus paid to the Executive by the Company prior to the date of termination or resignation, or (iii) if the termination occurs within the first
twelve (12) months following the Effective Date of this Agreement, then the Target Bonus Amount. Such payment shall be subject to standard deductions and withholdings and paid in equal monthly installments over the Compensation Severance Period
in accordance with the Company’s regular payroll policies and practices. 
 4.4.2.3 The vesting of each Company
equity award held by Executive shall accelerate on such date of termination (or the date of a Change in Control if the Executive has resigned for Good Reason within three (3) months before a Change in Control) by the number of shares that would
have vested in accordance with the applicable vesting had Executive remained employed by the Company for an additional nine (9) months as of the date of termination. During the nine (9) month period following the date of termination (the
“Benefit Severance Period”), Executive shall have continued exercisability of each Company stock option and stock appreciation right held by the Executive (if any). Notwithstanding the foregoing, any such stock option or
stock appreciation right 

  

 4. 

 
then held by Executive shall remain exercisable until the earlier of (1) the end of the Benefit Severance Period (2) the expiration of the ten-year
period measured from the original grant date, or (3) the expiration of its maximum term. In order to give effect to the intent of the foregoing provision, if a Change in Control has not occurred prior to the date of termination, no Company
equity award held by Executive shall expire, terminate or be forfeited any earlier than three (3) months following the date of termination. Notwithstanding anything to the contrary set forth herein, nothing in this Section 4.4.2.3
prohibits the Company or a successor organization (or its parent) from causing such awards to terminate in connection with a merger, consolidation or other corporate transaction pursuant to the terms of the applicable equity plan or award
agreements. 
 4.4.2.4 Assuming the Executive timely and accurately elects to continue his health insurance benefits
under the Consolidated Omnibus Budget Reconciliation Act of 1985 (“COBRA”), the Company shall pay the COBRA premiums for the Executive and his or her qualified beneficiaries until the earliest of (i) the end of the
Benefit Severance Period, (ii) the expiration of the Executive’s continuation coverage under COBRA and any applicable state COBRA-like statute that provides mandated continuation coverage or (iii) the date the Executive becomes
eligible for health insurance benefits of a subsequent employer. Executive agrees to immediately notify the Company in writing of any such eligibility. For purposes of this Section 4.4.3, references to COBRA premiums shall not include any
amounts payable by the Executive under an Internal Revenue Code Section 125 health care reimbursement plan. 
 4.4.3
Release. Notwithstanding the foregoing, the Executive shall not receive any of the severance payments or benefits set forth under Section 4.4.2, unless within the time period set forth therein, but in no event later than (i) if
a Change in Control shall have occurred prior to such Covered Termination, forty-five (45) days following termination of employment or (ii) if a Change in Control shall not have occurred prior to such Covered Termination, the later of
(A) forty-five (45) days following termination of employment or (B) ten (10) days following the effective date of such Change in Control, the Executive furnishes the Company with a waiver and release of claims in a form
acceptable to the Parties and substantially as attached hereto as Exhibit A, including such changes as may be made by the Company as necessary to comply with applicable laws (the “Release”), and permits such Release to become
effective in accordance with its terms. If a majority of the Board determines in good faith that the Executive has breached any provision of this Agreement or the Release, the Company shall be excused from the obligation to provide any severance
payment under Section 4.4.2; provided, however, that the Company shall not be entitled to recovery of any severance payment already provided to the Executive under Section 4.4.2. 
 4.4.4 No Mitigation. Amounts payable to the Executive under Section 4.4.2.1 and Section 4.4.2.2 shall not be
reduced by any amount of the Executive’s earnings from other employment during the Benefit Severance Period, if applicable, and, during the Benefit Severance Period, the Executive shall not have an affirmative duty to seek other employment or
otherwise mitigate the amount of any payment contemplated by this Agreement. 
  

 5. 

 4.5 Definitions. For purposes of this Agreement, the following terms shall have
the following meanings: 
 4.5.1 Complete Disability. “Complete Disability” shall mean the
inability of the Executive to perform the Executive’s duties under this Agreement because the Executive has become permanently disabled within the meaning of any policy of disability income insurance covering employees of the Company then in
force. In the event the Company has no policy of disability income insurance covering employees of the Company in force when the Executive becomes disabled, the term “Complete Disability” shall mean the inability of the Executive to
perform the Executive’s duties under this Agreement by reason of any incapacity, physical or mental, which the Board, based upon medical advice or an opinion provided by a licensed physician acceptable to the Board, determines to have
incapacitated the Executive from satisfactorily performing all of the Executive’s usual services for the Company for a period of at least one hundred twenty (120) days during any twelve (12) month period (whether or not consecutive).
Based upon such medical advice or opinion, the determination of the Board shall be final and binding and the date such determination is made shall be the date of such Complete Disability for purposes of this Agreement. 
 4.5.2 Cause. “Cause” for the Company to terminate Executive’s employment hereunder shall mean the occurrence
of one or more of the following events if such event results in a demonstrably harmful impact on the Company’s business or reputation, or that of any of its subsidiaries, as reasonably determined by the Board: 
 (i) Executive’s conviction of, or plea of guilty or no contest to, any felony or any crime involving fraud, dishonesty or
moral turpitude under the laws of the United States or any state thereof; 
 (ii) Executive’s commission of (or
attempted commission of), or participation in, a fraud or act of dishonesty against the Company; 
 (iii)
Executive’s material violation of any statutory duty owed to the Company or material violation of any policy or rule of the Company; 
 (iv) Executive’s unauthorized use or disclosure of the Company’s confidential information or trade secrets; 
 (v) Executive’s gross misconduct; or 
 (vi) Executive’s conduct that constitutes gross insubordination or habitual neglect of duties that is not cured within the
reasonable period provided by the Board or a committee designated by the Board in its written notice to Executive of such conduct. 
 The determination that
a termination is for Cause shall be made by the Board in good faith. Any determination that the Executive’s employment was terminated by reason of dismissal without Cause for the purposes of this Agreement shall have no effect upon any
determination of the rights or obligations of the Company or the Executive for any other purpose. 
  

 6. 

 4.5.3 Change in Control. “Change in Control” shall mean a transaction
(excluding in each case transactions in which securities are purchased from the Company for the principal purpose of raising capital for the Company) in which one of the following occurs: 
 (i) any person or related group of persons (other than the Parent or an affiliate of the Parent) directly acquires beneficial
ownership (within the meaning of Rule 13d-3 of the Securities Exchange Act of 1934) of securities possessing more than fifty percent (50%) of the total combined voting power of the Company’s outstanding securities; 
 (ii) the composition of the Board changes over a period of twenty-four (24) consecutive months or less in a way that results
in a majority of the Board (rounded up to the next whole number) ceasing, by reason of one or more proxy contests for the election of Board members, to be comprised of individuals who either (A) have been Board members continuously since the
beginning of the period or (B) have been elected or nominated for election as Board members during the period by at least two-thirds of the Board members described in clause (A) who were still in office at the time the election or
nomination was approved by the Board; 
 (iii) (A) a merger or consolidation occurs in which the Parent is not the
surviving entity, or (B) any reverse merger occurs in which the Parent is the surviving entity, or (C) any merger involving a subsidiary of the Parent occurs in which the Parent is a surviving entity, but in each case in which holders of
the Parent’s outstanding voting securities immediately prior to such transaction, as such, do not hold, immediately following such transaction, securities possessing fifty percent (50%) or more of the total combined voting power of the
surviving entity’s outstanding securities (in the case of clause (A)) or the Parent’s outstanding voting securities (in the case of clauses (B) and (C)); or 
 (iv) all or substantially all of the Parent’s assets are sold of transferred other than in connection with an internal
reorganization of the Parent or the Parent’s complete liquidation (other than a liquidation of the Parent into a wholly-owned subsidiary). 
 4.5.4 Covered Termination. “Covered Termination” means the Executive’s employment is terminated by the Company without Cause, or the Executive resigns for Good Reason within the
period commencing three (3) months before and ending twelve (12) months following a Change in Control (as defined above). 
 4.5.5 Good Reason. “Good Reason” means, with respect to the Executive, the occurrence of one or more of the following, without the Executive’s express written consent, provided that Executive has first
provided written notice to any member of the Board (or the surviving corporation, as applicable) within 90 days of the first such occurrence of such condition specifying the event(s) constituting Good Reason and specifying that Executive intends to
terminate employment not earlier than 30 days after providing such notice, and the Company (or surviving corporation) has not cured such event(s) within 30 days (or such longer period as may be specified by Executive in such notice) after such
written notice is received by such member of the Board (or by the surviving corporation) (the “Cure Period”), and Executive resigns within thirty (30) days following the end of the Cure Period: 
 (i) a material breach of the employment agreement by the Company; 
  

 7. 

 (ii) a material reduction in the Executive’s duties, authority or
responsibilities relative to the duties, or authority or responsibilities in effect immediately prior to such reduction; 
 (iii) a material reduction in the duties, authority or responsibilities of the supervisor to whom the Executive is required to report, including a requirement that the Executive report to a corporate officer or employee instead of
reporting directly to the Company’s board of directors; 
 (iv) a material reduction in the Executive’s base
salary or target bonus opportunity as in effect immediately prior to such reduction for any reason other than in connection with, and proportionate to, a company-wide pay reduction (provided that the Executive’s target bonus is part of the
Executive’s base compensation for purposes of Section 409A, as defined below); or 
 (v) an increase in the
Executive’s one-way driving distance from the Executive’s principal personal residence to the principal office or business location at which the Executive is required to perform services of more than 50 miles, except for required travel
for the Company’s business to an extent substantially consistent with Executive’s prior business travel obligations. 
 4.5.6 “Payment Commencement Date” means: 
 (i) with respect to a Covered Termination
resulting from the Executive resigning for Good Reason within the period commencing three (3) months before and ending twelve (12) months following a Change in Control, (A) if such Covered Termination occurs prior to the effective
date of the applicable Change in Control, the later of (1) the effective date of such Change in Control or (2) the effective date of the Release required by Section 4.4.4 or (B) if such Covered Termination occurs on or after the
effective date of the applicable Change in Control, the later of (1) the date of such Covered Termination or (2) the effective date of the Release required by Section 4.4.4. 
 (ii) with respect to a Covered Termination resulting from the Company terminating Executive without Cause, the later of
(1) the date of such Covered Termination or (2) the effective date of the Release required by Section 4.4.4. 
 4.6 Parachute Payments. Anything in this Agreement to the contrary notwithstanding, if any payment or benefit the Executive would receive from the Company pursuant to this Agreement or otherwise (a
“Payment”) would (i) constitute a “parachute payment” within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the “Code”), and (ii) but for this
sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment shall be equal to the Reduced Amount. The “Reduced Amount” shall be either
(x) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax or (y) the largest portion of the Payment, up to and including the total Payment, whichever amount, after taking into
account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate), results in the Executive’s receipt, 

  

 8. 

 
on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a
reduction in payments or benefits constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount, reduction shall occur in the following order: reduction of cash payments; cancellation of accelerated vesting
of stock awards; reduction of employee benefits. If acceleration of vesting of stock award compensation is to be reduced, such acceleration of vesting shall be cancelled in the reverse order of the date of grant of the Executive’s stock awards.

 The Company shall appoint a nationally recognized independent accounting firm to make the determinations required
hereunder, which accounting firm shall not then be serving as accountant or auditor for the individual, entity or group that effected the Change in Control. The Company shall bear all expenses with respect to the determinations by such accounting
firm required to be made hereunder. 
 The accounting firm engaged to make the determinations hereunder shall provide its
calculations, together with detailed supporting documentation, to the Company and the Executive within fifteen (15) calendar days after the date on which the Executive’s right to a Payment is triggered (if requested at that time by the
Company or the Executive) or such other time as requested by the Company or the Executive. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it
shall furnish the Company and the Executive with an opinion reasonably acceptable to the Executive that no Excise Tax will be imposed with respect to such Payment. The Company shall be entitled to rely upon the accounting firm’s determinations,
which shall be final and binding on all persons. 
 4.7 Exclusive Remedy. The rights, remedies and
payments set forth in this Section 4 shall be the exclusive rights, remedies and payments available to the Executive upon termination of this Agreement and the Executive’s employment hereunder. Such rights remedies and payments shall
supersede and replace any and all rights and remedies under state or federal law. To the extent permitted by applicable laws, the Company may deduct any amounts the Executive owes the Company at the time of the Executive’s termination of
employment from any severance payments. 
 4.8 Application of Section 409A. Notwithstanding anything to the
contrary set forth herein, any payments and benefits provided under this Agreement (the “Severance Benefits”) that constitute “deferred compensation” within the meaning of Section 409A of the Internal Revenue Code of 1986,
as amended (the “Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively “Section 409A”) shall not commence in connection with Executive’s termination of employment unless
and until Executive has also incurred a “separation from service” (as such term is defined in Treasury Regulation Section 1.409A-1(h) (“Separation From Service”). 
 It is intended that each installment of the Severance Benefits payments provided for in this Agreement is a separate “payment”
for purposes of Treasury Regulation Section 1.409A-2(b)(2)(i). For the avoidance of doubt, it is intended that payments of the Severance Benefits set forth in this Agreement satisfy, to the greatest extent possible, the exemptions from the
application of Section 409A provided under Treasury Regulation Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9). 

  

 9. 

 
However, if the Company (or, if applicable, the successor entity thereto) determines that the Severance Benefits, or a portion thereof, constitute
“deferred compensation” under Section 409A and Executive is, on the termination of Executive’s service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in
Section 409A(a)(2)(B)(i) of the Code, then, to the extent necessary to avoid the imposition of any additional tax or income recognition under Section 409A prior to actual payment to the Executive, the timing of the Severance Benefit
payments that constitute “deferred compensation” under Section 409A shall be delayed until the earlier to occur of: (i) the date that is six months and one day after Executive’s Separation From Service or (ii) the date
of Executive’s death (such applicable date, the “Specified Employee Initial Payment Date”). On the Specified Employee Initial Payment Date, the Company (or the successor entity thereto, as applicable) shall (A) pay to Executive a
lump sum amount equal to the sum of the Severance Benefit payments that Executive would otherwise have received through the Specified Employee Initial Payment Date if the commencement of the payment of the Severance Benefits had not been so delayed
pursuant to this Section and (B) commence paying the balance of the Severance Benefits in accordance with the applicable payment schedules set forth in this Agreement. 
 Except to the extent that payments are delayed until the Specified Employee Initial Payment Date pursuant to the preceding paragraph, on
the first regular payroll pay day following the Payment Commencement Date, the Company will pay Executive the Severance Benefits Executive would otherwise have received under the Agreement on or prior to such date but for the delay in payment
related to the effectiveness of the Release or the occurrence of the Change of Control, as applicable, with the balance of the Severance Benefits being paid as originally scheduled. All amounts payable under the Agreement will be subject to standard
payroll taxes and deductions. 
 It is the intent of this Agreement to comply with the requirements of Section 409A so
that none of the Severance Benefits to be provided hereunder will be subject to the additional tax imposed under Section 409A, and any ambiguities herein will be interpreted to so comply. The Company and the Executive agree to work together in
good faith to consider amendments to this Agreement and to take such reasonable actions which are necessary, appropriate or desirable to avoid imposition of any additional tax or income recognition under Section 409A prior to actual payment to
the Executive (provided that no such amendment shall materially reduce the benefits provided hereunder). 
 4.9 Survival of
Certain Sections. Sections 3.4, 4.4, 4.5, 4.6, 4.7, 4.8 and 5 - 16 of this Agreement shall survive the termination of this Agreement. 
  

	 	5.	CONFIDENTIAL AND PROPRIETARY INFORMATION; NONSOLICITATION. 

 5.1 Proprietary Information and Inventions Agreement. As a condition of employment, the Executive agrees to execute and
abide by the Proprietary Information and Inventions Agreement attached hereto as Exhibit B. 
 5.2
Non-Solicitation. During the Executive’s employment with the Company and the Benefit Severance Period and for one (1) year after the termination of such periods, the Executive agrees that in order to protect the
confidential and proprietary information of the Company and its subsidiaries from unauthorized use, the Executive shall not, either directly or through 

  

 10. 

 
others, solicit or attempt to solicit any employee, consultant or independent contractor of the Company or its subsidiaries to terminate his or her
relationship with the Company (or the applicable subsidiary) in order to become an employee, consultant or independent contractor to or for any other person or business entity. 
  

	 	6.	ASSIGNMENT AND BINDING EFFECT. 

 This Agreement shall be binding upon and inure to the benefit of the Executive and the Executive’s heirs, executors, personal
representatives, assigns, administrators and legal representatives. Because of the unique and personal nature of the Executive’s duties under this Agreement, neither this Agreement nor any rights or obligations under this Agreement shall be
assignable by the Executive. This Agreement shall be binding upon and inure to the benefit of the Company and its successors, assigns and legal representatives. 
  

	 	7.	CHOICE OF LAW. 

 This Agreement is made and intended to be performed primarily within the state of California. This Agreement shall be construed and interpreted in accordance with the internal laws of the state of California (without
giving effect to principles of conflicts of law). 
  

	 	8.	INTEGRATION. 

 Except
as may otherwise be provided herein, this Agreement, including Exhibit A and Exhibit B, contains the complete, final and exclusive agreement of the Parties relating to the terms and conditions of the Executive’s employment and the
termination of Executive’s employment, and supersedes all prior and contemporaneous oral and written employment agreements or arrangements between the Parties, including but not limited to the Prior Agreement. To the extent this Agreement
conflicts with the Proprietary Information and Inventions Agreement attached as Exhibit B, the Proprietary Information and Inventions Agreement controls. 
  

	 	9.	AMENDMENT. 

 This
Agreement cannot be amended or modified except by a written agreement signed by the Executive and the Board. 
  

	 	10.	WAIVER. 

 No term,
covenant or condition of this Agreement or any breach thereof shall be deemed waived, except with the written consent of the Party against whom the waiver is claimed, and any waiver or any such term, covenant, condition or breach shall not be deemed
to be a waiver of any preceding or succeeding breach of the same or any other term, covenant, condition or breach. 
  

 11. 

	 	11.	SEVERABILITY. 

 The
finding by a court of competent jurisdiction or other authorized body of the unenforceability, invalidity or illegality of any provision of this Agreement shall not render any other provision of this Agreement unenforceable, invalid or illegal. The
invalid or unenforceable term or provision shall be modified or replaced with a valid and enforceable term or provision which most accurately represents the Parties’ intention with respect to the invalid or unenforceable term or
provision. 
  

	 	12.	INTERPRETATION; CONSTRUCTION. 

 The headings set forth in this Agreement are for convenience of reference only and shall not be used in interpreting this Agreement. The Executive has been encouraged to consult with, and has consulted with,
Executive’s own independent counsel and tax advisors with respect to the terms of this Agreement. The Parties acknowledge that each Party and its counsel has reviewed and revised, or had an opportunity to review and revise, this Agreement, and
any rule of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Agreement. 
  

	 	13.	REPRESENTATIONS AND WARRANTIES. 

 The Executive represents and warrants that the Executive is not restricted or prohibited, contractually or otherwise, from entering into
and performing each of the terms and covenants contained in this Agreement, and that the Executive’s execution and performance of this Agreement shall not violate or breach any other agreements between the Executive and any other person or
entity. 
  

	 	14.	COUNTERPARTS. 

 This
Agreement may be executed in two counterparts, each of which shall be deemed an original, all of which together shall constitute one and the same instrument. 
  

	 	15.	ARBITRATION. 

 To
ensure the rapid and economical resolution of disputes that may arise in connection with the Executive’s employment with the Company, the Executive and the Company agree that any and all disputes, claims, or causes of action, in law or equity,
arising from or relating to Executive’s employment, or the termination of that employment, will be resolved, to the fullest extent permitted by law, by final binding arbitration in San Diego, California conducted by the Judicial Arbitration and
Mediation Services (“JAMS”), or its successors, under the then current rules of JAMS for employment disputes; provided that the arbitrator shall: (a) have the authority to compel adequate discovery for the
resolution of the dispute and to award such relief as would otherwise be permitted by law and (b) issue a written arbitration decision including the arbitrator’s essential findings and conclusions and a statement of the award. Both the
Executive and the Company shall be entitled to all rights and remedies that either the Executive or the Company would be entitled to pursue in a court of law. The Company shall pay all administrative fees associated with the arbitration and the fees
of the arbitrator. Nothing in this Agreement is intended to prevent either the Executive or the Company from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any 

  

 12. 

 
such arbitration. Notwithstanding the foregoing, the Executive and the Company each have the right to resolve any and all issues or disputes involving
confidential information, proprietary information, trade secrets or related information or intellectual property rights by court action instead of arbitration. 
  

	 	16.	TRADE SECRETS OF OTHERS. 

 It is the understanding of both the Company and the Executive that the Executive shall not divulge to the Company and/or its subsidiaries
any confidential information or trade secrets belonging to others, including the Executive’s former employers, nor shall the Company and/or its subsidiaries seek to elicit from the Executive any such information. Consistent with the foregoing,
the Executive shall not provide to the Company and/or its subsidiaries, and the Company and/or its subsidiaries shall not request, any documents or copies of documents containing such information. 
  

 13. 

 IN WITNESS WHEREOF, the Parties have
executed this Agreement as of the date first shown above. 
  

	
	TORREYPINES THERAPEUTICS, INC.
	
	/s/ Evelyn Graham
	EVELYN GRAHAM
	CHIEF EXECUTIVE OFFICER

  

	
	EXECUTIVE
	
	/s/ Paul Schneider
	PAUL SCHNEIDER
	VICE PRESIDENT AND
	GENERAL COUNSEL

  

 14. 

 EXHIBIT A 
 RELEASE AND WAIVER OF CLAIMS 
 In consideration of the payments and other benefits set forth in
Section 4.4 of the Employment Agreement dated February 1, 2007 (the “Employment Agreement”), to which this form is attached, I, Paul Schneider, hereby furnish TorreyPines Therapeutics, Inc. (the
“Company”), with the following release and waiver (“Release and Waiver”): 
 In exchange for the consideration provided to me by the Employment Agreement that I am not otherwise entitled to receive, I hereby generally and completely release the Company and its directors, officers, employees,
shareholders, partners, agents, attorneys, predecessors, successors, parent and subsidiary entities, insurers, affiliates, and assigns from any and all claims, liabilities and obligations, both known and unknown, that arise out of or are in any way
related to events, acts, conduct, or omissions occurring prior to my signing this Release and Waiver. This general release includes, but is not limited to: (1) all claims arising out of or in any way related to my employment with the Company or
the termination of that employment; (2) all claims related to my compensation or benefits from the Company, including, but not limited to, salary, bonuses, commissions, vacation pay, expense reimbursements, severance pay, fringe benefits,
stock, stock options, or any other ownership interests in the Company, except to the extent that such claims cannot be released pursuant to the California Labor Code, including, but not limited to, sections 2802 and 206.5; (3) all claims for
breach of contract, wrongful termination, and breach of the implied covenant of good faith and fair dealing; (4) all tort claims, including, but not limited to, claims for fraud, defamation, emotional distress, and discharge in violation of
public policy; and (5) all federal, state, and local statutory claims, including, but not limited to, claims for discrimination, harassment, retaliation, attorneys’ fees, or other claims arising under the federal Civil Rights Act of 1964
(as amended), the federal Americans with Disabilities Act of 1990, the federal Age Discrimination in Employment Act of 1967 (as amended) (“ADEA”), and the California Fair Employment and Housing Act (as amended).

 I also acknowledge that I have read and understand Section 1542 of the California Civil Code which reads as follows: “A
general release does not extend to claims which the creditor does not know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the
debtor.” I hereby expressly waive and relinquish all rights and benefits under that section and any law of any jurisdiction of similar effect with respect to any claims I may have against the Company. 
 If I am 40 years of age or older, I acknowledge that, among other rights, I am waiving and releasing any rights I may have under ADEA, that this Release
and Waiver is knowing and voluntary, and that the consideration given for this Release and Waiver is in addition to anything of value to which I was already entitled as an executive of the Company. I further acknowledge that I have been advised, as
required by the Older Workers Benefit Protection Act, that: (a) the release and waiver granted herein does not relate to claims under the ADEA which may arise after this Release and Waiver is executed; (b) I should consult with an attorney
prior to executing this Release and Waiver; (c) I have twenty-one (21) days in which to consider this Release and Waiver (although I may choose voluntarily to execute this Release and Waiver earlier); (d) I have seven (7) days
following the execution of this Release and Waiver to revoke my consent to this Release and Waiver; and (e) this Release and Waiver shall not be effective until the eighth day after I execute this Release and Waiver and the revocation period
has expired (the “Effective Date”). 

 I acknowledge and agree to my continuing obligations under my Proprietary Information and Inventions
Agreement, a copy of which is attached to the Employment Agreement. I understand and agree that my right to the severance pay I am receiving in exchange for my agreement to the terms of this Release and Waiver is contingent upon my continued
compliance with my Proprietary Information and Inventions Agreement. 
 I represent that I have not filed any claims against the Company, and
agree that, except as such waiver may be prohibited by statute, I will not file any claim against the Company or seek any compensation for any claim other than the payments and benefits referenced herein. I agree to indemnify and hold the Company
harmless from and against any and all loss, cost, and expense, including, but not limited to court costs and attorney’s fees, arising from or in connection with any action which may be commenced, prosecuted, or threatened by me or for my
benefit, upon my initiative, or with my aid or approval, contrary to the provisions of this Release and Waiver. 
 This Release and Waiver,
including any referenced documents, constitutes the complete, final and exclusive embodiment of the entire agreement between the Company and me with regard to the subject matter hereof. I am not relying on any promise or representation by the
Company that is not expressly stated herein. This Release and Waiver may only be modified by a writing signed by both me and a member of the Board of Directors of the Company. 
  

									
	Date:	 	 	 		 	By:	 	 
		 		 		 		 	

  

 2. 

 EXHIBIT B 
 [PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT] 
  

 1.

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