Document:

Director Retainer Plan

 Exhibit 10.3 
 FIRST COMMONWEALTH FINANCIAL CORPORATION 
 DIRECTOR RETAINER PLAN

  

	1.	Name and Purpose. 

 (a)
This plan shall be known as the First Commonwealth Financial Corporation Director Retainer Plan (the “Plan”). This Plan is adopted by the Compensation and Human Resources Committee (“Committee”) of the Board of Directors of First
Commonwealth Financial Corporation (the “Company”) pursuant to the First Commonwealth Financial Corporation Incentive Compensation Plan (the “Master Plan”) and shall be subject to the terms and conditions of the Master Plan. Each
capitalized term that is not otherwise defined in this Plan shall have the meaning given to such term in the Master Plan. 
 (b)
The purpose of this Plan is to enable the Company to attract and retain qualified persons to serve as Directors of the Company by providing a competitive retainer and to further align the interests of Directors with shareholders of the Company by
providing for the payment of a portion of the retainer in shares of Common Stock. 
  

	2.	Administration. 

 The Plan
shall be administered by the Committee. The Committee shall, subject to the applicable provisions of the Plan and the Master Plan, have full authority and discretion to interpret the Plan, to prescribe, amend and rescind rules and regulations
relating to the Plan, to prepare forms to use with respect to the Plan, and to make all determinations necessary or advisable for the administration of the Plan. The Committee’s determination as to any matter relating to the interpretation of
the Plan shall be conclusive on all persons. 
  

	3.	Eligible Participants. 

For purposes of the Plan, a “Director” refers to, as of any date, a person who is serving as a director of First Commonwealth
Financial Corporation who is not an employee of the Company or any Subsidiary. 
  

	4.	Retainer. 

 (a) Commencing
January 1, 2011, each Director shall be paid a retainer in the amount of $24,000 per year. Except for a Director who exercises his or her right to opt out of receiving shares of Common Stock in accordance with paragraph (b) of this
Section 4, each Director shall receive the annual retainer in two installments as follows: 
 (i) $6,000 in
cash payable on the date of the regular quarterly meeting of the Board of Directors in January (or, if no meeting is held in January, on January 31); and 
 (ii) A number of shares of Common Stock determined by dividing (x) $18,000 by (y) the Fair Market Value of the Common Stock as of the date preceding

 
the date of the Annual Meeting of Shareholders (or April 30 if the Annual Meeting is not held prior to that date). The shares issuable pursuant to this Section 4(a)(ii) shall be issued
in book entry form as soon as administratively practicable following the determination of Fair Market Value and shall not be subject to transfer restrictions or other Vesting Conditions. 

(b) Notwithstanding Section 4(a) above, any Director who owns at least 100,000 shares of Common Stock may elect to receive his or
her entire retainer in cash. That election must be made pursuant to a written notice delivered to the Secretary of the Company not later than February 28 of the year in which the election is to be effective. Each Director who has elected to
receive his or her entire retainer in cash pursuant to this Section 4(b) shall receive his or her retainer in four installments of $6,000 on the date of each quarterly meeting of the Board of Directors in January, April, July and October (or
the last day of the month if no meeting is held in that month). An election made pursuant to this Section 4(b) shall remain in effect unless and until the Director rescinds the election by written notice to the Secretary of the Company.

  

	5.	Miscellaneous Provisions. 

(a) The Committee may amend, suspend, or terminate this Plan at any time. 

(b) This Plan shall be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania except to the extent
such laws are superseded by the federal laws of the United States. 
 (c) This Plan shall take effect as of January 1, 2011
and shall supersede the Director Fee Stock Plan that was approved by the Committee on April 9, 2009 (the “Predecessor Plan”). The Predecessor Plan shall terminate as of December 31, 2010 and be of no further force or effect
thereafter.Second Amendment to Lease dated February 11, 2011

 Exhibit 10.29.1 

*Portions of this document marked [*] are requested to be treated confidentially. 

SECOND AMENDMENT TO LEASE 
 THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is entered into as of the 11th day of February, 2011 by and between EOS ACQUISITION I LLC, a Delaware limited liability company
(“Landlord”), and SALIX PHARMACEUTICALS, INC., a California corporation (“Tenant”). 
 W I T N E S
S E T H : 
 WHEREAS, Colonnade Development, LLC, a Delaware limited liability company
(“CD”) and Tenant entered into that certain Lease Agreement dated June 30, 2000, (the “Original Lease”) as amended by a First Amendment to Lease dated September 9, 2004 (collectively, the “Lease”), whereby
Landlord has leased to Tenant and Tenant has leased from Landlord approximately 26,363 rentable square feet, as shown on Exhibit A attached hereto, (the “Premises”) on the fifth (5th) floor of the building commonly known as The Colonnade – Building One located in Raleigh, North Carolina
(the “Building”); 
 WHEREAS, CD transferred its interest in the Building and assigned all the leases in the
Building to Landlord on October 3, 2006; 
 WHEREAS, Tenant currently subleases the Premises to Clinsys Clinical
Research, Inc. (“Clinsys”); 
 WHEREAS, Landlord and Tenant desire (i) to amend the terms of the Lease to
extend the term of the Lease and (ii) modify other certain terms and conditions of the Lease as further described herein. 

NOW, THEREFORE, for and in consideration of the mutual covenants and promises herein contained, the receipt and adequacy of which
are hereby acknowledged, the parties do hereby agree as follows: 
 1. Term. The Term of the Lease which was originally
scheduled to expire on April 22, 2011, is hereby extended until July 31, 2018 (the “Revised Expiration Date”). Such new period shall include a renovation and build-out period for the Premises of three (3) months and eight
(8) days (April 23, 2011 – July 31, 2011) followed by an extended term of seven (7) years (August 1, 2011 – July 31, 2018) (the “First Extension”). 

2. Premises. On April 23, 2011 the Premises shall be temporarily reduced by 13,441 rentable square feet as shown on Exhibit
A-1 attached hereto (the “Temporary Reduction Space”). During the period from April 23, 2011 until approximately June 1, 2011 Clinsys shall occupy the Temporary Reduction Space under a direct lease with Landlord until other space
in the Building is ready for Clinsys to occupy. During this period Tenant shall have no right to occupy the Temporary Reduction Space and the Temporary Reduction Space shall not be part of the Premises for any purpose under the Lease. Once Clinsys
vacates the Temporary Reduction Space to move to other space in the Building, which is expected to occur on June 1, 2011, but not expected to occur later than June 15, 2011, subject to Force Majeure Matters, the Temporary Reduction Space
shall once again become part of the Premises for all purposes under the Lease. In the event the Temporary Reduction Space is not delivered to Tenant on or before June 1, 2011, then for every day after June 1, 2011 that delivery is delayed
the following dates, which are noted above in Section 1, shall be extended on a day-for-day basis: (i) the date of the Revised Expiration Date (July 31, 2018, but no later than August 31, 2018), (ii) the end date for the
build-out period (July 31, 2011), and (iii) the dates of the First Extension (August 1, 2011 and July 31, 2018, but no later than August 31, 2018 and the First Extension shall be shortened as necessary not to pass such date).

 
Landlord shall use commercially reasonable efforts to ensure Clinsys vacates the Temporary Reduction Space during the timeframe noted above. In the event Landlord is unable to deliver the
Temporary Reduction Space to Tenant on or before December 1, 2011 then Tenant must either: (a) accept the Premises without the Temporary Reduction Space in which case this Second Amendment shall be revised as necessary such as to reduce
and adjust Base Rental and any other numbers that are affected or (b) Tenant may elect to continue to wait for the delivery of the Temporary Reduction Space. In either case, Landlord shall continue to utilize commercially reasonable efforts to
cause Clinsys to vacate the Temporary Reduction Space so that such space may be delivered to Tenant. Following such efforts, if Landlord is successful and Tenant selected item (a) above, a reasonable amendment shall be prepared to once again
include the Temporary Reduction Space within the Premises. 
 3. Rental. During the First Extension Tenant shall pay Base
Rent as follows: 
  

							
	 Period*
	  	 Base Rental per

rentable square foot
	  	 Monthly

Base Rental
	  	 Annual

Base Rental

				
	 [*]
	  	$[*]	  	  $0.00	  	  [*]
				
	 [*]
	  	$[*]	  	$[*]	  	  [*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]
				
	 [*]
	  	$[*]	  	$[*]	  	$[*]

  

	*	The periods in the rent table shall be adjusted, if necessary, as described in Section 2 above. 

4. Additional Rent. During the First Extension Tenant shall continue to pay the Operating Cost Escalation, as set forth in
Section 4.2 of the Lease, provided, however, beginning on the first day of the First Extension the Operating Costs Expense Stop (as defined in Section 1.1 of the Lease) shall be redefined to be the actual Landlord’s Operating Costs
incurred during calendar year 2011 on a per square foot basis. 
 5. Improvements to the Premises; Tenant Improvement
Allowance; Space Planning Allowance; Training Room; Office Enclosures Allowance; Moving Allowance; Lights. 
 a. Tenant shall
be permitted to perform renovations, alterations and improvements to the Premises at Tenant’s sole cost and expense, subject to subsection (b) below, in accordance with plans and specifications reasonably approved in advance by Landlord
(the “Tenant Improvements”). The Tenant Improvements shall be performed in accordance with the applicable terms of the Lease. 
 b. Provided that Tenant is not then in default under the Lease beyond the expiration of any applicable notice and grace periods, Landlord shall contribute up to $[*] per rentable square foot, which
equates to [*] and [*] Dollars ($[*]) (the “Tenant Improvement Allowance”) toward the cost of the Tenant Improvements. Except as otherwise expressly provided herein, the Tenant Improvement Allowance shall be applicable
only to the following costs: (i) any cost of installing improvements and alterations in the Premises as shown on plans approved by Landlord, (ii) design costs for architectural, mechanical, plumbing and electrical design of the Tenant
Improvements, and (iii) construction documents and permits. Prior to commencing any construction, Tenant shall provide Landlord with a copy of the contract between Tenant and its general contractor and copies of the applicable building permits.
Tenant 

  

	*	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  
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shall also provide Landlord with the dates such work is anticipated to commence and anticipated to be completed. Upon Tenant’s request, Landlord shall pay for those costs (to the extent
covered by the Tenant Improvement Allowance) directly to the contractors and vendors, as requested by Tenant, based upon invoices submitted to Landlord. Landlord shall make such payments within thirty (30) days of Tenant’s request therefor
which request must also contain the following: (a) the contractor’s pay application (G702, G703) and (b) the general contractor’s conditional lien waivers. In the event that Tenant does not expend all of the Tenant Improvement
Allowance for costs permitted hereunder on or before June 30, 2012, the unused portion of the Tenant Improvement Allowance, if any, shall be retained by Landlord and shall be deemed forfeited by Tenant. 

c. Landlord shall contribute a maximum amount of [*] and [*] Dollars ($[*]) per rentable square foot of the Premises
toward the preliminary space planning expenses of the Tenant Improvements which shall be paid directly to the design professional upon receipt of applicable invoices. 
 d. Tenant anticipates that the plans for the Tenant Improvements will include a training room which will include an accordion door division (the “Training Space”). In the event applicable code
and regulations require additional restroom stalls to be installed in the Building due to the Training Space, the cost of such restroom stalls shall be a Tenant expense and may come from the Tenant Improvement Allowance to the extent available.
Tenant shall return the Premises to Landlord at the end of the Term, including the Training Room space, in accordance with the terms of the Lease which means Tenant must remove any non-standard additions to such space. 

e. Provided that Tenant is not then in default under the Lease beyond the expiration of any applicable notice and grace periods, Landlord
agrees to provide to Tenant an allowance (the “Moving Allowance”) in the maximum amount of [*] Dollars ($[*]) per rentable square foot of the Premises ($[*]), to be applied solely to moving costs incurred by Tenant in
relocating back to the Premises, telephone systems, computer set-up and networking, project management services, furniture acquisition, additional Tenant improvement work, information technology equipment and other equipment, stationary and business
cards, and costs related to the Monument Sign and Exterior Sign, as such terms are defined below (the “Moving Costs”). Tenant shall submit paid invoices for all Moving Costs to Landlord on or before December 31, 2011 and Landlord
shall reimburse Tenant for the Moving Costs evidenced by the invoices (up to the maximum amount of the Moving Allowance) within thirty (30) days after receipt of all such invoices. In the event Tenant does not expend all of the Moving Allowance
for Moving Costs permitted hereunder by such date, the unused portion of the Moving Allowance, if any, shall be retained by Landlord and shall be deemed forfeited by Tenant. In no event shall Landlord be obligated to reimburse Tenant for any Moving
Costs in excess of the Moving Allowance. 
 f. On or before April 10, 2011 Tenant shall provide notice to Landlord that
Tenant will either: (i) reduce the Tenant Improvement Allowance by [*] and [*] Dollars ($[*]) or (ii) provide Landlord with one hundred fifty eight (158) 2’x4’ parabolic Building standard light fixtures
which shall be delivered to the Building in a location designated by Landlord on or before April 15, 2011 for use in other portions of the Building not including the Premises. 

6. Security Deposit. The Security Deposit amount under the Lease shall no longer apply as of April 23, 2011 and to the extent
necessary Landlord shall return the letter of credit which serves as the Security Deposit to Tenant within thirty (30) days of such date. 
 7. After Hours HVAC. The after-hours HVAC rate listed as $[*] per hour in Section 2 of the Special Provisions of the Lease shall be amended to read $[*] per hour. 

  

	*	Confidential treatment requested; certain information omitted and filed separately with the SEC. 

  
 3 

 8. Deletions from Lease. The following sections are hereby deleted from the Lease:
Sections 3, 4, 5, 6, and 7 of the Special Provisions. 
 9. Additional Amendments to Lease. 

a. Tenant’s commercial general liability insurance requirement limits listed at the end of Section 1.1 of the Lease shall be
updated to read: Three Million Dollars ($3,000,000) combined single limit aggregate for bodily injury or death or damage to property. 
 10. Signage. Landlord shall permit Tenant to install, at Tenant’s sole cost and expense, including the cost of any separate electricity meter, tenant identification signage on the exterior of
the Building in an area approximately 66 square feet in size on the Six Forks Road side of the Building (the “Exterior Sign”) and on the Building’s monument sign (the “Monument Sign”) in locations reasonably determined by
Landlord. All signage installations shall be in accordance with Building standards and subject to any applicable governmental laws or regulations and any restrictive covenants. Additionally, except for transfers to a Related Assignee in which case
the signage rights shall transfer, the signage rights under this Lease shall be personal to Tenant and shall be deemed void in the event this Lease is ever assigned to a party that is not a Related Assignee or more than fifty (50%) of the
Premises is sublet to another party. 
 Tenant shall pay all maintenance and electricity costs for the Exterior Sign and all
maintenance costs for the Monument Sign (which only includes Tenant’s sign panel and not any portion of the monument sign structure unless Tenant causes damage to the structure). At the end of the Term or earlier termination of this Lease,
Tenant shall pay all costs to remove the Exterior Sign and Monument Sign and to repair any damage caused thereby. 
 11.
Option to extend Term. 
 a. Tenant shall have and is hereby granted the option to extend the Term hereof for one
(1) period of four (4) years and six (6) months commencing on the date immediately following the Revised Expiration Date (the “Extension Period”), provided (i) Tenant delivers written notice (the “Extension
Notice”) to Landlord, not less than nine (9) months prior to the Revised Expiration Date, time being of the essence, of Tenant’s irrevocable election to exercise such Extension Period; (ii) no Event of Default exists at the time
of the exercise of such Extension Period or arises subsequent thereto, which event by notice and/or the passage of time would constitute an Event of Default if not cured within the applicable cure period; and (iii) Tenant has not assigned its
interest in the Lease or sublet more than fifty percent (50%) of the Premises. 
 b. All terms and conditions of the Lease,
including without limitation all provisions governing the payment of Operating Costs and Base Rent, shall remain in full force and effect during the Extension Period, except that Base Rent (on a per rentable square foot basis) payable during the
Extension Period shall equal the Fair Market Rental Rate (hereinafter defined) at the time of the commencement of the Extension Period. As used in this Lease, the term “Fair Market Rental Rate” shall mean the fair market rental rate that
would be agreed upon between a landlord and a tenant entering into a new lease for comparable space as to location, configuration, size and use, in a comparable building as to quality, reputation and age which is located in the Raleigh-Durham, North
Carolina submarket, with a comparable build-out and a comparable term and comparable tenant credit, assuming the landlord and tenant are informed and well-advised and each is acting in what it considers its own best interests when determining the
Fair Market Rental Rate. 

  
 4 

 c. Landlord and Tenant shall negotiate in good faith to determine the Annual Base Rent for
the Extension Period, for a period of thirty (30) days after the date on which Landlord receives Tenant’s written notice of Tenant’s irrevocable election to exercise the Extension Period. In the event Landlord and Tenant are unable to
agree upon the Annual Base Rent of the Extension Period within said thirty (30)-day period, the Fair Market Rental Rate for the Premises shall be determined by a board of three (3) licensed real estate brokers, one of whom shall be named by the
Landlord, one of whom shall be named by Tenant, and the two so appointed shall select a third. Each real estate broker so selected shall be licensed in the State of North Carolina as a real estate broker specializing in the field of office leasing
in Raleigh, North Carolina, having no fewer than ten (10) years experience in such field, and recognized as ethical and reputable within the field. Landlord and Tenant agree to make their appointments promptly within ten (10) days after
the expiration of the thirty (30)-day period, or sooner if mutually agreed upon. The two (2) brokers selected by Landlord and Tenant shall promptly select a third broker within ten (10) days after they both have been appointed, and each
broker, within fifteen (15) days after the third broker is selected, shall submit his or her determination of the Fair Market Rental Rate. The Fair Market Rental Rate shall be the mean of the two closest rental rate determinations, provided
however, in no event shall the Annual Base Rent for the first Lease Year of the Extension Period be less (on a per square foot basis) than the fully-escalated Annual Base Rent in effect for the last Lease Year of the initial Term. Landlord and
Tenant shall each pay the fee of the broker selected by it, and they shall equally share the payment of the fee of the third broker. 
 d. Should the Term of the Lease be extended hereunder, Tenant shall, if required by Landlord, execute an amendment modifying the Lease within ten (10) days after Landlord presents same to Tenant,
which agreement shall set forth the Annual Base Rent for each year of the Extension Period and the other economic terms and provisions in effect during the Extension Period. Should Tenant fail to execute the amendment (which amendment accurately
sets forth the economic terms and provisions in effect during the Extension Period) within ten (10) business days after presentation of same by Landlord, time being of the essence, Tenant’s right to extend the Term of the Lease shall, at
Landlord’s sole option, terminate, and Landlord shall be permitted to lease such space to any other person or entity upon whatever terms and conditions are acceptable to Landlord in its sole discretion. 

12. Right of First Offer. 
 Provided (i) no Event of Default exists at the time or arises subsequent thereto, which event by notice and/or the passage of time would constitute an Event of Default if not cured within the
applicable cure period, and (ii) Tenant has not assigned this Lease nor sublet all or any portion of the Premises (other than an assignment or sublease to a Related Assignee), beginning on the first day of the First Extension and thereafter
until the end of the First Extension, Tenant shall have a continuing right of first offer to lease the office space on the first (1st), third (3rd) and fourth (4th) floors of the Building at such time as any such space becomes available for lease (the applicable available
space being defined as the “Expansion Space”); provided, however, Tenant shall have no right to lease any portion of such space which is re-leased to existing tenants occupying such space. Tenant’s rights under this Section 12
are subordinate to the following parties, or their successors and assigns, who have previously been granted rights of first offer, rights of first refusal, or other expansion rights on the floors noted for each: Wachovia Securities – 1st floor; AECOM – 3rd floor. Additionally, Tenant’s rights
shall not apply to any space covered by leases or expansions Landlord is currently negotiating with the following tenants on the floors noted: Wachovia Securities – 1st floor; Wisdom and Wealth – 3rd floor; Clinsys – 4th floor. Once Tenant’s rights under this Section 12 are applicable, then at such time as Expansion Space
becomes available for lease and prior to marketing the Expansion Space for lease to the general public, Landlord shall notify Tenant in writing of Landlord’s intention to market the Expansion Space and the rental rate and terms and conditions
of lease which Landlord intends to propose for the Expansion Space including the size of such space (collectively, the “Offer Terms”). 

  
 5 

 Tenant shall have seven (7) business days after its receipt of such written notice from
Landlord (the “Letter of Intent Negotiation Period”) to provide written notice to Landlord evidencing its intent to exercise said right of first offer and to lease the Expansion Space in accordance with such Offer Terms. Landlord shall
not, during the Letter of Intent Negotiation Period, lease the Expansion Space to any other party unless Tenant advises Landlord that Tenant is not interested in leasing the Expansion Space in accordance with the Offer Terms. In the event that
Tenant does not agree to such Offer Terms during the Letter of Intent Negotiation Period, then, after such period, Landlord may market the Expansion Space upon substantially the same terms and conditions as contained in the Offer Terms and Tenant
shall have no further rights with respect to the Expansion Space until such time as the Expansion Space again becomes available for lease or in the event Landlord substantially changes the Offer Terms (which shall also apply to the economic terms),
whereupon Tenant shall again have the option to exercise this right of first offer in accordance with this Section 12. 

In the event Tenant agrees to the Offer Terms within the Letter of Intent Negotiation Period as hereinabove described, then Tenant and
Landlord will negotiate in good faith and with due diligence an agreement for the lease of the Expansion Space. Landlord shall not, during the ten (10) day period immediately following Tenant’s agreement to the Offer Terms (the “Lease
Negotiation Period”), lease, offer to lease or agree to lease the Expansion Space to any other party. In the event that Landlord and Tenant are unable in good faith to agree to the terms of such lease within the Lease Negotiation Period, then
thereafter Landlord may market the Expansion Space upon substantially the same terms and conditions as contained in the Offer Terms whereupon Tenant shall have no further rights with respect to the Expansion Space until such time as the Expansion
Space again becomes available for lease, or in the event Landlord substantially changes the Offer Terms (which shall also apply to the economic terms), whereupon Tenant shall again have the option to exercise this right of first offer in accordance
with this Section 12. 
 13. Broker. Landlord and Tenant represent and warrant each to the other that they have not
dealt with any broker(s) or any other person claiming any entitlement to any commission in connection with this transaction except CB Richard Ellis and Jones Lang LaSalle (collectively, the “Broker(s)”). Tenant agrees to indemnify and save
Landlord harmless from and against any and all claims, suits, liabilities, costs, judgments and expenses, including reasonable attorneys’ fees, for any leasing commissions or other commissions, fees, charges or payments due, owing, or made to a
broker (except as provided immediately below) in connection with this Second Amendment. Landlord agrees to indemnify and save Tenant harmless from and against any and all claims, suits, liabilities, costs, judgments and expenses, including
reasonable attorneys’ fees, for any leasing commissions or other commissions, fees, charges or payments due, owing, or made to a broker in connection with this Second Amendment. Landlord expressly agrees and acknowledges that Landlord is
responsible for the full payment of any leasing commissions due Broker(s) pursuant to a separate written agreement with such Broker(s). 
 14. USA Patriot act and anti-terrorism laws. 
 Tenant represents and
warrants to, and covenants with, Landlord that neither Tenant nor any of its respective constituent owners or affiliates currently are, or shall be at any time during the Term hereof, in violation of any laws relating to terrorism or money
laundering (collectively, the “Anti-Terrorism Laws”), including without limitation Executive Order No. 13224 on Terrorist Financing, effective September 24, 2001 and relating to Blocking Property and Prohibiting Transactions With
Persons Who Commit, Threaten to Commit, or Support Terrorism (the “Executive Order”) and/or the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Public Law 107-56)
(the “USA Patriot Act”). Notwithstanding the foregoing, Tenant is a publicly traded company and therefore Tenant’s representations about its shareholders shall be limited to Tenant’s actual knowledge. 

  
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 Tenant covenants with Landlord that neither Tenant nor any of its respective constituent
owners or affiliates is or shall be during the Term hereof a “Prohibited Person,” which is defined as follows: (i) a person or entity that is listed in the Annex to, or is otherwise subject to, the provisions of the Executive Order;
(ii) a person or entity owned or controlled by, or acting for or on behalf of, any person or entity that is listed in the Annex to, or is otherwise subject to the provisions of, the Executive Order; (iii) a person or entity with whom
Landlord is prohibited from dealing with or otherwise engaging in any transaction by any Anti-Terrorism Law, including without limitation the Executive Order and the USA Patriot Act; (iv) a person or entity who commits, threatens or conspires
to commit or support “terrorism” as defined in Section 3(d) of the Executive Order; (v) a person or entity that is named as a “specially designated national and blocked person” on the then-most current list published by
the U.S. Treasury Department Office of Foreign Assets Control at its official website, http://www.treas.gov/offices/eotffc/ofac/sdn/t11sdn.pdf, or at any replacement website or other replacement official publication of such list; and
(vi) a person or entity who is affiliated with a person or entity listed in items (i) through (v), above. 
 At any
time and from time-to-time during the Term, Tenant shall deliver to Landlord, within ten (10) days after receipt of a written request therefor, a written certification or such other evidence reasonably acceptable to Landlord evidencing and
confirming Tenant’s compliance with this Section 14. 
 15. Ratification. Except as expressly or by necessary
implication amended or modified hereby, the terms of the Lease are hereby ratified, confirmed and continued in full force and effect, and Landlord and Tenant represent that neither has any knowledge of a default by the other under the Lease.

 16. Landlord Notice Address and Rent Payment Address. Landlord’s notice address and the address for the payment
of Rent as listed in Section 1.1 of the Lease is deleted in their entirety and replaced with the following: 
  

	
	 Notice:

	 EOS Acquisition I LLC

c/o KBS Realty Advisors

	 1909 K Street NW, Suite 340

	 Washington, D.C. 20006

	 Attn: Asset Manager

	
	 With a copy to:

	 CB Richard Ellis Asset Services

	 4208 Six Forks Road, Suite 1220

	 Raleigh, NC 27609

	
	 Rent Address:

	 EOS Acquisition I, LLC – EO 1120

	 P.O. Box 6076

	 Hicksville, New York 11802-6076

 17. Commencement Agreement. Reference is made to the form of Declaration of Dates (the “Declaration”) attached hereto as Exhibit B. After the commencement of the First Extension Landlord
shall complete the Declaration and deliver the completed Declaration to Tenant. Within five (5) days after Tenant receives the completed Declaration from Landlord, Tenant shall execute and return the Declaration to Landlord to confirm the dates
of the First Extension. Failure to execute the Declaration shall not affect the commencement or expiration of the First Extension. 
 18. Conduit. Landlord shall reasonable cooperate with Tenant’s efforts to install a conduit (the “Conduit”) from the Building to a neighboring building known as Colonnade II
(“Colonnade II”). Tenant shall pay all costs and expenses to accomplish the Conduit installation including all of Landlord’s 

  
 7 

 
reasonable administrative, attorney, and design fees. Tenant shall coordinate any necessary approvals and documentation needed from the owner of Colonnade II. Landlord shall have the right to
approve the method and location of installation of the Conduit and may withhold approval if, in Landlord’s reasonable opinion, the installation causes interference with Landlord’s operation or use of the Building including its common area.
Tenant shall maintain the Conduit at Tenant’s sole cost and expense. Tenant shall indemnify Landlord for any damages, costs or expenses related to the installation, use or maintenance of the Conduit. At the end of the Term of the Lease,
Landlord may require Tenant to remove the Conduit at Tenant’s sole cost and expense. 
 19. Contingency. Tenant is
negotiating a new lease for space in Colonnade II with the owner of such building (the “Colonnade II Lease”). In the event Tenant does not finalize and execute the Colonnade II Lease on or before 1:00 p.m. EST on February 14, 2011,
then Tenant may terminate this Second Amendment by sending written notice to such affect to Landlord and Landlord’s counsel at the addresses or facsimile numbers listed below which notice must be received on or before February 14, 2011 at
1:00 p.m. EST (the “Termination Notice”). In the event Landlord does not receive the Termination Notice on or before such date and time then this Section shall be deemed automatically terminated from the Second Amendment and shall no
longer apply for any reason. 
 To Landlord: 
 EOS Acquisition I LLC 
 Attn: Robin Burke 
 1909 K Street NW, Suite 340 
 Washington, DC 20006 

Fax: (202) 822-1340 
 To Landlord’s
Attorney: 
 David E. Wagner 
 K&L
Gates LLP 
 4350 Lassiter at North Hills Avenue 
 Suite 300 (27609) 
 Post Office Box 17047 
 Raleigh, North Carolina 27619-7047 
 Fax: (919) 516-2016 

20. Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of
which taken together shall constitute one and the same instrument. A facsimile or PDF copy of a signature shall be as binding as an original copy and the parties expect to initially exchange PDF copies of their signatures in order to create a
binding agreement. 
 [SIGNATURE PAGE FOLLOWS] 

  
 8 

 IN WITNESS WHEREOF, the parties hereto have caused this Second Amendment to be
executed as of the day and year first above written. 
  

	
	LANDLORD:
	
	 EOS ACQUISITION I LLC,

a Delaware limited liability company

	
	 By: KBS Realty Advisors, LLC,

a Delaware limited liability company,
 its
authorized agent

  

			
	By:	 	  

	Name:	 	Robin A. Burke
	Title:	 	Senior Vice President

  

	
	TENANT:
	
	 SALIX PHARMACEUTICALS, INC.,
 a California corporation

  

			
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 9 

 EXHIBIT A 

DEPICTION OF PREMISES 

 

 

  
 10 

 EXHIBIT A-1 

DEPICTION OF TEMORARY REDUCTION SPACE 

 

 

  
 11 

 EXHIBIT B 
 DECLARATION OF DATES 
 This Declaration Dates is made as of
                    , 20    , by EOS ACQUISITION I LLC (“Landlord”), and SALIX PHARMACEUTICALS, INC.
(“Tenant”), who agree as follows: 
 1. Landlord and Tenant entered into a Lease Amendment dated
                    , 2011, in which Landlord leased to Tenant, and Tenant leased from Landlord, certain Premises described therein in the
office building located at 8540 Colonnade Center Drive, Raleigh, North Carolina 27615 (the “Building”). All capitalized terms herein are as defined in the Lease. 
 2. Pursuant to the Lease, Landlord and Tenant agreed to and do hereby confirm the following matters as of the Lease: 
  

	 	a.	the beginning date of the First Extension of the Lease is
                    ; 

  

	 	b.	the Revised Expiration Date of the Lease is
                    ; 

  

	 	c.	the number of rentable square feet of the Premises is
                    ; 

  

	 	d.	Tenant’s Pro Rata Share (Operating Expenses) is
                    %; and 

  

	 	e.	Tenant’s Pro Rata Share (Real Estate Taxes) is
                    %. 

 3. Tenant confirms that: 
  

	 	a.	it has accepted possession of the Premises as provided in the Lease; 

  

	 	b.	Landlord is not required to perform any work or furnish any improvements to the Premises under the Lease; 

 

	 	c.	Landlord has fulfilled all of its obligations under the Lease as of the date hereof; 

 

	 	d.	the Lease is in full force and effect and has not been modified, altered, or amended, except as follows:
                                        ;
and 

  

	 	e.	there are no set-offs or credits against Rent, and no Security Deposit or prepaid Rent has been paid except as provided by the Lease. 

4. The provisions of this Declaration Dates shall inure to the benefit of, or bind, as the case may require, the parties and their
respective successors and assigns, and to all mortgagees of the Building, subject to the restrictions on assignment and subleasing contained in the Lease, and are hereby attached to and made a part of this Lease. 

  
 12 

 
					
	LANDLORD:
	
	EOS ACQUISITION I LLC, a Delaware limited liability company
		
	By:	 	 KBS Capital Advisors, LLC, a Delaware
 limited liability company, its authorized agent

			
		 	By:	 	  

		 		 	Robin A. Burke
		 		 	Senior Vice President
	
	TENANT:
	
	SALIX PHARMACEUTICALS, INC., a California corporation
			
		 	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

  
 13

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