Document:

Exhibit 10.2

 

 

SUBORDINATION AGREEMENT

 

THIS SUBORDINATION
AGREEMENT (this “Agreement”) is entered into as of March 4, 2014, by and among Platinum-Montaur Life Sciences
LLC, a Delaware limited liability company (together with its permitted successors and assigns, the “Subordinated Creditor”),
and Oxford Finance LLC, a Delaware limited liability company, in its capacity as agent for the lenders under the Senior Loan Agreement
(as defined below) (together with its successors and assigns, in such capacity, the “Senior Creditor Agent”),
and is consented to and acknowledged by Navidea Biopharmaceuticals, Inc., a Delaware corporation (the “Borrower”,
and together with any other borrower or guarantor of the Senior Debt (as defined below), collectively, the “Company”).

 

RECITALS

 

A.The Company
has entered into the Loan and Security Agreement, dated as of the date hereof (as amended, restated, supplemented, replaced, increased
or otherwise modified from time to time in accordance with the terms hereof, the “Senior Loan Agreement”), by
and among (a) the Company, (b) Senior Creditor Agent, and (c) the financial institutions or other entities signatory
thereto from time to time as Lenders (such Lenders and any other holders from time to time of any of the Senior Debt, collectively,
the “Senior Creditor”), pursuant to which Senior Creditor Agent and Senior Creditor have made and may make certain
loans from time to time to the Company on the terms and conditions set forth therein. All of the Company’s obligations to
Senior Creditor Agent and Senior Creditor under the Senior Debt Documents (as hereinafter defined) are secured by first-priority
liens on and security interests in all of the property of the Company in which the Company purports to grant a security interest
from time to time under the Senior Debt Documents and the products and proceeds thereof (collectively, the “Collateral”).

 

B.Subordinated
Creditor has extended and may in the future extend loans to the Company under that certain Loan Agreement, dated as of July 25,
2012, between the Borrower and the Subordinated Creditor, as amended as of the date hereof (and as further amended, restated, supplemented
or otherwise modified in accordance with the terms hereof, the “Subordinated Loan Agreement”), which loans are
evidenced by that certain Promissory Note (Term Loan Facility) dated as of July 25, 2012 in the original principal
amount of $35,000,000, as amended as of the date hereof (and as further amended, restated, supplemented, replaced or modified in
accordance with the terms hereof, the “Subordinated Note”). All of the Company’s obligations evidenced
by the Subordinated Debt Documents are and will remain unsecured obligations.

 

C.As an
inducement for Senior Creditor Agent and Senior Creditor to continue their loans and other financial accommodations to Company
and as a condition precedent under the Senior Loan Agreement, the Subordinated Creditor is executing this Agreement in order to
set forth the relative rights and priorities of Senior Creditor Agent, Senior Creditor and Subordinated Creditor under the Senior
Debt Documents and the Subordinated Debt Documents (as hereinafter defined).

 

    	 

    	 

    

 

NOW, THEREFORE,
in consideration of the above and the premises, the covenants and agreements contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which hereby are acknowledged, the parties hereto hereby agree as follows:

 

1.Definitions.
The following terms shall have the following meanings in this Agreement:

 

“Amendment
to Subordinated Loan Agreement” shall mean that certain Amendment to Loan Agreement, dated as of the date hereof,
between the Subordinated Creditor and the Company, amending the Subordinated Loan Agreement.

 

“Bankruptcy
Code” shall mean Title 11 of the United States Code, as amended from time to time and any successor statute
and all rules and regulations promulgated thereunder.

 

“Distribution”
shall mean, with respect to any indebtedness, obligation or security, (a) any payment or distribution by any Person of cash,
securities or other property, including, without limitation, by the application of proceeds from the disposition of Collateral,
by set-off or otherwise, on account of or to pay principal, interest or any other obligation owing in respect of such indebtedness,
obligation or security, (b) any redemption, purchase or other acquisition of such indebtedness, obligation or security by
any Person or (c) the granting of any lien or security interest to or for the benefit of the holders of such indebtedness,
obligation or security in or upon any property of any Person.

 

“Enforcement
Action” shall mean (a) to take from or for the account of the Company or any guarantor of the Subordinated Debt,
by set-off or in any other manner, the whole or any part of any moneys which may now or hereafter be owing by the Company or any
such guarantor with respect to the Subordinated Debt, (b) to sue for payment of, or to initiate or participate with others
in any suit, action or proceeding against the Company or any such guarantor (including any initiation of any Proceeding against
the Company or such guarantor) to (i) enforce payment of or to collect the whole or any part of the Subordinated Debt or (ii) commence
judicial enforcement of any of the rights and remedies under the Subordinated Debt Documents or applicable law with respect to
the Subordinated Debt, (c) to accelerate the Subordinated Debt, (d) to sell, license, lease, or otherwise dispose of
all or any portion of any Collateral, any other assets of the Company or any such guarantor, or any other collateral whatsoever,
by private or public sale, other disposition or any other means permissible under applicable law, (e) to exercise any put
option or to cause the Company or any such guarantor to honor any redemption or mandatory prepayment obligation under any Subordinated
Debt Document, (f) to notify account debtors or directly collect accounts receivable or other payment rights of the Company
or any such guarantor the solicitation of bids from third parties to conduct the liquidation of any Collateral, any other assets
of the Company or any such guarantor, or any other collateral whatsoever, (g) to engage or retain sales brokers, marketing
agents, investment bankers, accountants, appraisers, auctioneers or other third parties for the purposes of valuing, marketing,
promoting and selling any Collateral, any other assets of the Company or any such guarantor, or any other collateral whatsoever,
(h) to exercise any other right relating to any Collateral, any other assets of the Company or any such guarantor, or any
other collateral whatsoever (including the exercise of any voting rights relating to any capital stock and including any right
of recoupment or set-off) or (i) to take any action under the provisions of any state or federal law, including, without limitation,
the Bankruptcy Code and the Uniform Commercial Code, or under any contract or agreement, to enforce, set-off against, foreclose
upon, take possession of or sell or otherwise dispose of any Collateral, any other assets of the Company or any such guarantor,
or any other collateral whatsoever. For the avoidance of doubt, neither (x) termination of the obligation of the Subordinated
Creditor to fund Draws (as such term is defined in the Subordinated Loan Agreement) in accordance with Sections 2.2(f) or
7.2(i) of the Subordinated Loan Agreement nor (y) any Subordinated Debt Conversion shall be deemed an Enforcement Action.

 

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“Person”
shall mean any natural person, corporation, general or limited partnership, limited liability company, firm, trust, association,
government, governmental agency or other entity, whether acting in an individual, fiduciary or other capacity.

 

“Proceeding”
shall mean any voluntary or involuntary insolvency, bankruptcy, receivership, custodianship, liquidation, dissolution, reorganization,
assignment for the benefit of creditors, appointment of a custodian, receiver, trustee or other officer with similar powers or
any other proceeding for the liquidation, dissolution or other winding up of a Person.

 

“Refinancing
Senior Debt Documents” shall mean any financing documentation which replaces any Senior Debt Documents and pursuant
to which the Senior Debt or any portion thereof is refinanced, as such financing documentation may be amended, restated, supplemented,
replaced, increased or otherwise modified from time to time; provided, that, any such Refinancing Senior Debt Documents
shall contain substantially the same terms and conditions as the Senior Debt Documents as in effect on the date hereof (subject
to such modifications as may be permitted by Section 3.1 hereof).

 

“Senior
Debt” shall mean all obligations, liabilities and indebtedness of every nature of the Company from time to time owed
to Senior Creditor Agent and Senior Creditor under the Senior Debt Documents, including, without limitation, the principal amount
of all debts, claims and indebtedness, accrued and unpaid interest, prepayment premiums and all fees, costs and expenses, whether
primary, secondary, direct, contingent, fixed or otherwise, heretofore, now and from time to time hereafter owing, due or payable,
whether before or after the filing of a Proceeding under the Bankruptcy Code together with (a) any amendments, restatements,
modifications, renewals, increases or extensions thereof in accordance with the terms hereof and (b) any interest, fees, expenses,
premiums or other amounts accruing thereon after the commencement of a Proceeding, without regard to whether or not such interest,
fees, expenses, premiums or other amounts are allowed or allowable in whole or in part in any such Proceeding; provided
that in no event shall the principal amount of Senior Debt exceed $36,000,000. Senior Debt shall be considered to be outstanding
whenever any loan or loan commitment under any Senior Debt Document is outstanding.

 

“Senior
Debt Documents” shall mean collectively, the Senior Loan Agreement and all other “Loan Documents” as
defined in the Senior Loan Agreement and, after any refinancing of the Senior Debt, the Refinancing Senior Debt Documents, all
as amended, restated, supplemented, replaced, increased or otherwise modified from time to time in accordance with the terms hereof.

 

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“Subordinated
Debt” shall mean all obligations, liabilities and indebtedness of every nature of the Company from time to time owed
to Subordinated Creditor under the Subordinated Debt Documents, including, without limitation, the principal amount of all debts,
claims and indebtedness, accrued and unpaid interest and all fees, costs and expenses, whether primary, secondary, direct, contingent,
fixed or otherwise, heretofore, now and from time to time hereafter owing, due or payable, whether before or after the filing of
a Proceeding under the Bankruptcy Code together with (a) any amendments, restatements, modifications, renewals, increases
or extensions thereof in accordance with the terms hereof and (b) any interest, fees, expenses, premiums or other amounts
accruing thereon after the commencement of a Proceeding, without regard to whether or not such interest, fees, expenses, premiums
or other amounts are allowed or allowable in whole or in part in any such Proceeding.

 

“Subordinated
Debt Conversion” shall mean any conversion of the Subordinated Debt into common stock of the Borrower at any time
after the date hereof, pursuant to the terms and conditions of Section 2.7 of the Subordinated Loan Agreement, in each case
only so long as no cash is paid by the Company in connection with the consummation of such conversion.

 

“Subordinated
Debt Documents” shall mean the Subordinated Loan Agreement, the Subordinated Note, any guaranty with respect to the
Subordinated Debt, any agreements or documents entered into in connection with any Subordinated Debt Conversion, and all other
documents, agreements and instruments now existing or hereinafter entered into evidencing or pertaining to all or any portion of
the Subordinated Debt, all as amended, supplemented, replaced or modified from time to time in accordance with the terms hereof.

 

“Subordination
Termination Date” shall mean the date that all outstanding Senior Debt (other than contingent indemnity obligations
that survive termination of the Senior Loan Documents and for which no claim has been asserted) is paid in full in cash (or otherwise
repaid to the satisfaction of the Senior Creditor) and Senior Creditor Agent and Senior Creditor have no further obligation to
make loans or provide any other financial accommodations to Company pursuant to the Senior Debt Documents.

 

2.Subordination.

 

2.1Subordination
of Subordinated Debt to Senior Debt. The Company covenants and agrees, and Subordinated Creditor by its execution hereof
or its acceptance of the Subordinated Loan Agreement and any Subordinated Note (whether upon original issue or upon transfer or
assignment) likewise covenants and agrees, notwithstanding anything to the contrary contained in any of the Subordinated Debt Documents,
that the payment of any and all of the Subordinated Debt shall be subordinate and subject in right and time of payment, to the
extent and in the manner set forth in this Agreement, to the prior indefeasible payment in full in cash of all Senior Debt. Each
holder of Senior Debt, whether such Senior Debt is now outstanding or hereafter created, incurred, assumed or guaranteed, shall
be deemed to have acquired Senior Debt in reliance upon the provisions contained in this Agreement. Notwithstanding the terms of
the Subordinated Debt Documents, the Company agrees that it will not make, and Subordinated Creditor agrees that it will not accept,
any Distribution, whether in cash, securities or other property, with respect to or as payment for the Subordinated Debt until
the Subordination Termination Date (including, without limitation, any amounts owing pursuant to Section 3.2 of the Subordinated
Loan Agreement other than pursuant to a Subordinated Debt Conversion); provided, however, that (a) so long as no Default
or Event of Default (as such terms are defined in the Senior Loan Agreement) has occurred, is continuing or would result therefrom,
the Company may pay, and the Subordinated Creditor may accept, regularly scheduled payments of interest at the non-default rate
on the Subordinated Debt paid in cash in accordance with the terms of the Subordinated Debt Documents as in effect on the date
hereof or as modified in accordance with the terms of this Agreement and (b) the Borrower may issue to the Subordinated Creditor,
and the Subordinated Creditor may accept, common stock of the Borrower in connection with a Subordinated Debt Conversion.

 

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2.2Liquidation,
Dissolution, Bankruptcy. In the event of any Proceeding involving the Company:

 

(a)The
Company shall not make and Subordinated Creditor shall not receive any Distribution in such Proceeding, whether in cash, securities
or other property (other than equity received upon a Subordinated Debt Conversion), on account of or as payment for any Subordinated
Debt prior to the Subordination Termination Date.

 

(b)Any
Distribution received in such Proceeding, whether in cash, securities or other property (other than equity received upon a Subordinated
Debt Conversion) that would otherwise, but for the terms hereof, be payable or deliverable in respect of the Subordinated Debt
shall be paid or delivered directly to Senior Creditor Agent (to be held and/or applied by Senior Creditor Agent in accordance
with the terms of the Senior Debt Documents) until the Subordination Termination Date. Subordinated Creditor irrevocably authorizes,
empowers and directs any debtor, debtor-in-possession, receiver, trustee, liquidator, custodian, conservator or other Person having
authority, to pay or otherwise deliver all such Distributions to Senior Creditor Agent. Subordinated Creditor also irrevocably
authorizes and empowers Senior Creditor Agent, in the name of Subordinated Creditor, to demand, sue for, collect and receive any
and all such Distributions and other amounts owing under the Subordinated Debt Documents.

 

(c)Subordinated
Creditor agrees not to initiate, prosecute or participate in any claim, action or other proceeding challenging the enforceability,
validity, perfection or priority of the Senior Debt or any liens and security interests securing the Senior Debt.

 

(d)Subordinated
Creditor agrees that Senior Creditor Agent and Senior Creditor may consent to the use of cash collateral or provide financing (including
debtor-in-possession financing) to the Company on such terms and conditions and in such amounts as Senior Creditor Agent and Senior
Creditor, in their sole discretion, may decide and, in connection therewith, the Company may grant to Senior Creditor Agent and
Senior Creditor liens and security interests upon all of the property of the Company, which liens and security interests (i) shall
secure payment of all Senior Debt (whether such Senior Debt arose prior to the commencement of any Proceeding or at any time thereafter)
and all other financing provided by Senior Creditor Agent and Senior Creditor during such Proceeding and (ii) shall be superior
in priority to the liens and security interests, if any, in favor of Subordinated Creditor on the property of the Company. Subordinated
Creditor agrees that it will not object to or oppose a sale or other disposition of any property securing all or any part of the
Senior Debt free and clear of security interests, liens or other claims of Subordinated Creditor under Section 363 of the
Bankruptcy Code or any other provision of the Bankruptcy Code if Senior Creditor Agent or Senior Creditor has consented to such
sale or disposition. Subordinated Creditor agrees not to assert any right it may have to “adequate protection” of Subordinated
Creditor’s interest in any Collateral or any other assets of the Company in any Proceeding and agrees that it will not seek
to have the automatic stay lifted with respect to any Collateral or any other assets of the Company without the prior written consent
of Senior Creditor Agent. Subordinated Creditor waives any claim it may now or hereafter have arising out of Senior Creditor Agent’s
or Senior Creditor’s election, in any Proceeding instituted under the Bankruptcy Code, of the application of Section 1111(b)(2)
of the Bankruptcy Code, and/or any borrowing or grant of a security interest under Section 364 of the Bankruptcy Code by the
Company, as debtor-in-possession. Subordinated Creditor further agrees that it will not participate or seek to participate on any
creditor’s committee without Senior Creditor Agent’s prior written consent.

 

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(e)Subordinated
Creditor agrees to execute, verify, deliver and file any proofs of claim in respect of the Subordinated Debt reasonably requested
by Senior Creditor Agent in connection with any such Proceeding and hereby irrevocably authorizes, empowers and appoints Senior
Creditor Agent its agent and attorney-in-fact to (i) execute, verify, deliver and file such proofs of claim upon the failure
of Subordinated Creditor promptly to do so prior to 30 days before the expiration of the time to file any such proof of claim and
(ii) vote the full amount of such claim in any such Proceeding; provided that Senior Creditor Agent shall have no obligation
to execute, verify, deliver, file and/or vote any such proof of claim or claim. In the event that Senior Creditor Agent votes any
claim in accordance with the authority granted hereby, Subordinated Creditor shall not be entitled to change or withdraw such vote.

 

(f)The
Senior Debt shall continue to be treated as Senior Debt and the provisions of this Agreement shall continue to govern the relative
rights and priorities of Senior Creditor Agent, Senior Creditor and Subordinated Creditor even if all or part of the Senior Debt
or the security interests securing the Senior Debt are subordinated, set aside, avoided, invalidated, or disallowed in connection
with any such Proceeding, and this Agreement shall be reinstated if at any time any payment of any of the Senior Debt is rescinded
or must otherwise be returned by any holder of Senior Debt or any representative of such holder.

 

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2.3Subordinated
Debt Standstill Provisions. Until the Subordination Termination Date, Subordinated Creditor shall not, without the prior
written consent of Senior Creditor Agent, take any Enforcement Action with respect to the Subordinated Debt. Any Distributions
or other proceeds of any Enforcement Action obtained by Subordinated Creditor in violation of the immediately preceding sentence
shall in any event be held in trust by it for the benefit of Senior Creditor Agent and Senior Creditor and promptly paid or delivered
to Senior Creditor Agent in the form received. Notwithstanding any provision of this Agreement to the contrary, Subordinated Creditor
may take any action solely to the extent necessary to prevent the running of any applicable statute of limitations or other similar
restriction on claims, including the submission of any proof of claim in respect of the Subordinated Debt in any Proceeding.

 

2.4Incorrect
Payments and Payover. Until the Subordination Termination Date, if any Distribution on account of or as payment for the
Subordinated Debt that is not permitted to be made by the Company or accepted by Subordinated Creditor under this Agreement is
nonetheless made or received by Subordinated Creditor, such Distribution shall not be commingled with any of the assets of Subordinated
Creditor, shall be held in trust by Subordinated Creditor for the benefit of Senior Creditor Agent and Senior Creditor and shall
be promptly paid over to Senior Creditor Agent for application (in accordance with the Senior Debt Documents) to the payment of
the Senior Debt then remaining unpaid.

 

2.5Subordination
of Liens and Security Interests; Agreement Not to Contest; Agreement to Release Liens; Acknowledgement of Liens.

 

(a)The
obligations owed to Subordinated Creditor are not (x) guaranteed by, or constitute the obligations of, any person other than
Borrower (except to the extent that such person has guaranteed the Senior Debt) or (y) secured by the assets of Company or
any other person.

 

(b)The
obligations owed to Subordinated Creditor shall remain unsecured. Notwithstanding the immediately preceding sentence, if Subordinated
Creditor obtains any liens or security interests in the Collateral or any other assets of the Company (whether pursuant to Senior
Creditor Agent’s consent or otherwise), all such liens and security interests obtained by Subordinated Creditor in the Collateral
and any other assets of the Company shall be and hereby are subordinated for all purposes and in all respects to the liens and
security interests of Senior Creditor Agent in the Collateral and any other assets of the Company, regardless of the validity,
enforceability, avoidance, dispute, unperfection, or the time, method, manner or order of the grant, attachment, filing or perfection
of any such liens and security interests, any provision of the Uniform Commercial Code, the Bankruptcy Code, any Senior Debt Document
or any Subordinated Debt Document or any other circumstance whatsoever until the Subordination Termination Date. Subordinated Creditor
agrees that it will not at any time contest the validity, perfection, priority or enforceability of the Senior Debt, the Senior
Debt Documents, or the liens and security interests of Senior Creditor Agent in the Collateral or any other assets of the Company
securing the Senior Debt. In the event that Senior Creditor Agent releases or agrees to release any of its liens or security interests
in the Collateral or any other assets of the Company in connection with the sale or other disposition thereof, or if any of the
Collateral or any other assets of the Company is sold or retained pursuant to a foreclosure or similar action, Subordinated Creditor
agrees that its liens or security interests in such Collateral and other assets of the Company, if any, shall automatically be
released, and Subordinated Creditor shall (or shall cause its agent to) promptly execute and deliver to Senior Creditor Agent or
authorize Senior Creditor Agent to file such termination statements and releases as Senior Creditor Agent shall reasonably request
to effect the release of the liens and security interests of Subordinated Creditor in such Collateral or other assets of the Company.
In furtherance of the foregoing, Subordinated Creditor hereby irrevocably appoints Senior Creditor Agent its attorney-in-fact,
with full authority in the place and stead of Subordinated Creditor and in the name of Subordinated Creditor or otherwise, to execute
and deliver any document or instrument which Subordinated Creditor may be required to deliver pursuant to this subsection 2.5(a).

 

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(c)Subordinated
Creditor acknowledges and agrees that Senior Creditor Agent has been granted liens upon and security interests in the Collateral
for the benefit of Senior Creditor Agent and Senior Creditor. Subordinated Creditor agrees that it shall not obtain a lien on or
security interest in any property of the Company to secure all or any portion of the Subordinated Debt unless it obtains the prior
written consent of Senior Creditor Agent and, concurrently therewith, Senior Creditor Agent obtains a first priority lien on and
security interest in such asset or collateral and the parties hereby agree that all such liens and security interests are and will
be subject to this Agreement. Subordinated Creditor agrees that it shall not obtain any control agreement with respect to any deposit
account, securities account or other property of the Company without the prior written consent of Senior Creditor Agent.

 

2.6Application
of Proceeds from Sale or other Disposition of the Collateral. Until the Subordination Termination Date, in the event of
any sale, transfer, lease, license or other disposition (including a casualty loss or taking through eminent domain) of the Collateral
or any other asset of the Company, the proceeds resulting therefrom (including proceeds from insurance or any other Enforcement
Action) shall be applied in accordance with the terms of the Senior Debt Documents or as otherwise consented to by Senior Creditor
Agent.

 

2.7Sale,
Transfer or other Disposition of Subordinated Debt.

 

(a)Subordinated
Creditor shall not sell, assign, pledge, dispose of or otherwise transfer all or any portion of the Subordinated Debt or any Subordinated
Debt Document other than (i) to any affiliate of Platinum-Montaur Life Sciences LLC upon the delivery to Senior Agent of a
written acknowledgement and joinder to this Agreement, in form and substance satisfactory to Senior Agent and providing for the
continued subordination and forbearance of the Subordinated Debt to the Senior Debt as provided herein and the continued effectiveness
of all of the rights of the Senior Agent or (ii) the disposal of any Subordinated Debt in connection with a Subordinated Debt
Conversion.

 

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(b)Notwithstanding
the foregoing subsection 2.7(a), the debt and lien subordination effected by this Agreement shall survive any sale, assignment,
pledge, disposition or other transfer of all or any portion of the Subordinated Debt in violation of the terms of subsection 2.7(a),
and the terms of this Agreement shall be binding upon the successors and assigns of Subordinated Creditor, as provided in Section 10
hereof.

 

2.8Legends.
Until the Subordination Termination Date, Subordinated Creditor will cause to be clearly, conspicuously and prominently inserted
on the face of the Subordinated Note and any other Subordinated Debt Document, as well as any renewals or replacements thereof,
the following legend:

 

“This
instrument and the indebtedness, rights and obligations evidenced hereby and any liens or other security interests securing such
rights and obligations are subordinate in the manner and to the extent set forth in that certain Subordination Agreement (as amended,
restated, supplemented or modified from time to time, the “Subordination Agreement”) dated as of March 4, 2014,
by and among the Subordinated Creditor identified therein and Oxford Finance LLC in its capacity as agent for certain lenders (together
with its successors and assigns, “Senior Creditor Agent”), to certain indebtedness, rights, and obligations
of Navidea Biopharmaceuticals, Inc. to Senior Creditor Agent and Senior Creditor (as defined therein) and liens and security interests
of Senior Creditor Agent securing the same all as described in the Subordination Agreement; and each holder and transferee of this
instrument, by its acceptance hereof, irrevocably agrees to be bound by the provisions of the Subordination Agreement.”

 

3.Modifications.

 

3.1Modifications
to Senior Debt Documents. Senior Creditor Agent or Senior Creditor may at any time and from time to time without the consent
of or notice to Subordinated Creditor, without incurring liability to Subordinated Creditor and without impairing or releasing
the obligations of Subordinated Creditor under this Agreement, change the manner or place of payment or extend the time of payment
of or renew or alter any of the terms of the Senior Debt, or amend in any manner any Senior Debt Document, including without limitation
to increase the Senior Debt; provided, that Senior Creditor shall not, without the prior written consent of holders of greater
than fifty percent (50%) of the then-outstanding principal balance of the Subordinated Debt, agree to any modification, supplement
or amendment to the Senior Debt Documents, the effect of which is to (a) increase the principal amount of the Senior Debt
to an amount in excess of the amount permitted pursuant to the definition of “Senior Debt” herein, (b) increase
any applicable interest rate with respect to the Senior Debt by more than 200 basis points except in connection with the imposition
of the default rate of interest currently set forth in the Senior Debt Documents, (c) impose any additional restriction on
the Borrower’s ability or right to make payments on the Subordinated Debt beyond what is contemplated hereunder, (d) extend
the final maturity of the Senior Debt (as set forth in the Senior Debt Documents as in effect on the date hereof) to a date after
the final stated maturity date of the Subordinated Debt or (e) permit any re-borrowing of principal amounts repaid with respect
to the Senior Debt.

 

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3.2Modifications
to Subordinated Debt Documents. Until the Subordination Termination Date, and notwithstanding anything to the contrary
contained in the Subordinated Debt Documents, neither the Company nor Subordinated Creditor shall, without the prior written consent
of Senior Creditor Agent, agree to any amendment, modification, waiver or supplement to the Subordinated Debt Documents.

 

4.Waiver
of Certain Rights by Subordinated Creditor.

 

4.1Notice.
To the fullest extent permitted by applicable law, Subordinated Creditor hereby waives any right to receive the following notices
from Senior Creditor Agent: (a) notice of acceptance hereof; (b) notice of any loans or other financial accommodations
made or extended under the Senior Debt Documents, or the creation or existence of any Senior Debt; (c) notice of the amount
of the Senior Debt; (d) notice of any adverse change in the financial condition of Company or any account debtor or of any
other fact that might increase Subordinated Creditor’s risk hereunder; (e) notice of presentment for payment, demand,
protest, and notice thereof as to any instrument among the Senior Debt Documents; (f) notice of any default or event of default
under the Senior Debt Documents or otherwise relating to the Senior Debt; and (g) all other notices (except if such notice
is specifically required to be given to Subordinated Creditor under this Agreement) and demands to which Subordinated Creditor
might otherwise be entitled. Notwithstanding anything to the contrary, Subordinated Creditor is not waiving, and shall not be deemed
to have waived, any rights that Subordinated Creditor has as a stockholder of the Company, including any voting, consent or information
rights. Moreover, nothing contained herein shall be deemed to be a waiver of, and Subordinated Creditor is not waiving, any notice
obligations that the Company has to Subordinated Creditor.

 

4.2Marshaling.
Subordinated Creditor hereby waives any rights it may have under applicable law to assert the doctrine of marshaling or to otherwise
require Senior Creditor Agent to marshal any property of the Company or any guarantor of the Senior Debt for the benefit of Subordinated
Creditor.

 

4.3Rights
Relating to Senior Creditor Agent’s Actions with respect to the Collateral.

 

(a)Subordinated
Creditor hereby waives, to the extent permitted by applicable law, any rights which it may have to enjoin or otherwise obtain a
judicial or administrative order preventing Senior Creditor Agent and/or Senior Creditor from taking, or refraining from taking,
any action with respect to all or any part of the Collateral or any other assets of the Company. Without limitation of the foregoing,
Subordinated Creditor hereby agrees (a) that it has no right to direct or object to the manner in which Senior Creditor Agent
and/or Senior Creditor applies the proceeds of the Collateral or any other assets of the Company resulting from the exercise by
Senior Creditor Agent and/or Senior Creditor of rights and remedies under the Senior Debt Documents to the Senior Debt and (b) that
Senior Creditor Agent and/or Senior Creditor has not assumed any obligation to act as the agent for Subordinated Creditor with
respect to the Collateral or any other assets of the Company. Senior Creditor Agent and/or Senior Creditor shall have the exclusive
right to enforce rights and exercise remedies with respect to the Collateral and any other assets of the Company until Subordination
Termination Date. In exercising rights and remedies with respect to the Collateral or any other assets of the Company, Senior Creditor
Agent and/or Senior Creditor may enforce the provisions of the Senior Debt Documents and exercise remedies thereunder, all in such
order and in such manner as they may determine in the exercise of their sole business judgment. Such exercise and enforcement shall
include, without limitation, the rights to sell or otherwise dispose of Collateral or any other assets of the Company, to incur
expenses in connection with such sale or disposition and to exercise all the rights and remedies of a secured lender under the
Uniform Commercial Code of any applicable jurisdiction. In conducting any public or private sale under the Uniform Commercial Code,
Senior Creditor Agent shall give Subordinated Creditor such notice of such sale only to the extent required by the applicable Uniform
Commercial Code; provided, however, that if such notice is required to be given, 10 days’ notice shall be deemed
to be commercially reasonable notice. Subordinated Creditor agrees that neither Senior Creditor Agent nor Senior Creditor shall
incur any liability to Subordinated Creditor as a result of a sale, lease, license, application or other disposition of all or
any portion of the Collateral or any other assets of the Company or any part or proceeds thereof conducted in accordance with applicable
law.

 

    	10

    	 

    

 

(b)None
of Senior Creditor Agent, Senior Creditor or any of their respective affiliates, directors, officers, employees, or agents shall
be liable to Subordinated Creditor for failure to demand, collect, or realize upon any of the Collateral or any proceeds thereof
or for any delay in doing so or shall be under any obligation to sell or otherwise dispose of any Collateral or proceeds thereof
or to take any other action whatsoever with regard to the Collateral or any part or proceeds thereof. If Senior Creditor Agent
or Senior Creditor should act upon, omit to act upon, or exercise any of their contractual rights or remedies under the Senior
Debt Documents (subject to the express terms and conditions hereof), neither Senior Creditor Agent nor Senior Creditor shall have
any liability whatsoever to the Subordinated Creditor as a result of such action, omission, or exercise.

 

4.4Additional
Rights of Senior Creditor Agent and Senior Creditor. Senior Creditor Agent and Senior Creditor will be entitled to manage
and supervise the loans and extensions of credit under the Senior Debt Documents as Senior Creditor Agent and Senior Creditor may,
in their sole discretion, deem appropriate, and Senior Creditor Agent and Senior Creditor may manage their loans and extensions
of credit without regard to any rights or interests that Subordinated Creditor may have in the Collateral or any other assets of
the Company or otherwise. Senior Creditor Agent, Senior Creditor and each holder of Senior Debt may, from time to time, enter into
agreements and settlements with the Company or other parties to the Senior Debt Documents in accordance with the provisions of
Section 3.1 of this Agreement as it may determine in its sole discretion without impairing any of the subordinations, priorities,
rights or obligations of the parties under this Agreement, including substituting collateral and releasing any lien on any Collateral
or any other asset of the Company.

 

    	11

    	 

    

 

4.5Additional
Defenses. To the fullest extent permitted by applicable law, Subordinated Creditor hereby waives: (a) any rights to
assert against Senior Creditor Agent or Senior Creditor any defense (legal or equitable), set-off, counterclaim, or claim which
Subordinated Creditor may now or at any time hereafter have against the Company, any other holder of Senior Debt, any other party
liable to Senior Creditor Agent or Senior Creditor, or any Person constituting Subordinated Creditor; (b) any defense, set-off,
counterclaim, or claim, of any kind or nature, arising directly or indirectly from the present or future lack of perfection, sufficiency,
validity, or enforceability of any Senior Debt, any Subordinated Debt or any security for either; (c) any defense arising
by reason of any claim or defense based upon an election of remedies by Senior Creditor Agent or Senior Creditor; and (d) the
benefit of any statute of limitations affecting the obligations of Subordinated Creditor hereunder or the enforcement thereof,
and any act which shall defer or delay the operation of any statute of limitations applicable to the Senior Debt shall similarly
operate to defer or delay the operation of such statute of limitations applicable to such obligations of Subordinated Creditor
hereunder.

 

4.6Notice
of Defaults. The Subordinated Creditor shall use commercially reasonable efforts to provide the Senior Creditor Agent written
notice of the occurrence of an Event of Default (as such term is defined in the Subordinated Loan Agreement), provided that the
failure to provide such a notice shall not be deemed a breach of this Agreement. The Senior Creditor Agent shall use commercially
reasonable efforts to provide the Subordinated Creditor written notice of the occurrence of an Event of Default (as such term is
defined in the Senior Loan Agreement), provided that the failure to provide such a notice shall not be deemed a breach of this
Agreement or otherwise affect the subordination of the Subordinated Debt as provided in this Agreement.

 

5.Representations
and Warranties.

 

5.1Representations
and Warranties of Subordinated Creditor. Subordinated Creditor hereby represents and warrants to Senior Creditor Agent,
for the benefit of Senior Creditor Agent and Senior Creditor, that as of the date hereof: (a) it is a limited liability company
duly formed and validly existing under the laws of the jurisdiction of its formation; (b) it has the power and authority to
enter into, execute, deliver and carry out the terms of this Agreement, all of which have been duly authorized by all proper and
necessary action; (c) the execution of this Agreement by Subordinated Creditor will not violate or conflict with its organizational
documents, any material agreement binding upon it or any law, regulation or order or require any consent or approval which has
not been obtained; (d) this Agreement is the legal, valid and binding obligation of Subordinated Creditor, enforceable against
it in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting the enforcement of creditors’ rights generally and by equitable principles; (e) it
is the sole owner, beneficially and of record, of the Subordinated Debt Documents and the Subordinated Debt; (f) neither Subordinated
Creditor, nor its agent, has any liens or security interests in the Collateral or any other assets of the Company; and (g) such
Person has no contractual put right to require that the Company redeem any equity securities.

 

    	12

    	 

    

 

5.2Representations
and Warranties of Senior Creditor Agent. Senior Creditor Agent hereby represents and warrants to Subordinated Creditor
that as of the date hereof: (a) Senior Creditor Agent is a limited liability company duly formed and validly existing under
the laws of the jurisdiction of its formation; (b) Senior Creditor Agent has the power and authority to enter into, execute,
deliver and carry out the terms of this Agreement, all of which have been duly authorized by all proper and necessary action; (c) the
execution of this Agreement by Senior Creditor Agent will not violate or conflict with the organizational documents of Senior Creditor
Agent, any material agreement binding upon Senior Creditor Agent or any law, regulation or order or require any consent or approval
which has not been obtained; (d) this Agreement is the legal, valid and binding obligation of Senior Creditor Agent, enforceable
against Senior Creditor Agent in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors’ rights generally or by equitable
principles and (e) the Senior Loan Agreement does not permit the re-borrowing of funds advanced thereunder and repaid.

 

6.Subrogation.
On and after the Subordination Termination Date, Subordinated Creditor shall be subrogated to the rights of Senior Creditor Agent
and Senior Creditor to receive Distributions with respect to the Senior Debt until the Subordinated Debt is paid in full. Subordinated
Creditor agrees that in the event that all or any part of a payment made with respect to the Senior Debt is recovered from the
holders of the Senior Debt in a Proceeding or otherwise, any Distribution received by Subordinated Creditor with respect to the
Subordinated Debt at any time after the date of the payment that is so recovered, whether pursuant to the right of subrogation
provided for in this Agreement or otherwise, shall be deemed to have been received by Subordinated Creditor in trust as property
of the holders of the Senior Debt and Subordinated Creditor shall forthwith deliver the same to Senior Creditor Agent for application
to the Senior Debt until the Subordination Termination Date. A Distribution made pursuant to this Agreement to Senior Creditor
Agent which otherwise would have been made to Subordinated Creditor is not, as between the Company and Subordinated Creditor, a
payment by the Company to or on account of the Senior Debt. WITHOUT LIMITING THE GENERALITY OF ANY OTHER WAIVER OR OTHER PROVISION
SET FORTH IN THIS AGREEMENT, SUBORDINATED CREDITOR HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ALL RIGHTS AND DEFENSES
ARISING OUT OF AN ELECTION OF REMEDIES BY SENIOR CREDITOR AGENT OR SENIOR CREDITOR, EVEN THOUGH THAT ELECTION OF REMEDIES HAS DESTROYED
SUBORDINATED CREDITOR’S RIGHTS OF SUBROGATION AND REIMBURSEMENT AGAINST THE COMPANY BY THE OPERATION OF ANY APPLICABLE LAW.

 

    	13

    	 

    

 

7.Modification.
Any modification or waiver of any provision of this Agreement, or any consent to any departure by any party from the terms hereof,
shall not be effective in any event unless the same is in writing and signed by Senior Creditor Agent and Subordinated Creditor,
and then such modification, waiver or consent shall be effective only in the specific instance and for the specific purpose given.
Any notice to or demand on any party hereto in any event not specifically required hereunder shall not entitle the party receiving
such notice or demand to any other or further notice or demand in the same, similar or other circumstances unless specifically
required hereunder.

 

8.Further
Assurances. Each party to this Agreement promptly will execute and deliver such further instruments and agreements and
do such further acts and things as may be reasonably requested in writing by any other party hereto that may be necessary or desirable
in order to effect fully the purposes of this Agreement.

 

9.Notices.
Unless otherwise specifically provided herein, any notice delivered under this Agreement shall be in writing addressed to the respective
party as set forth below and may be personally served, faxed or sent by overnight courier service or registered or certified United
States mail, return receipt requested, and shall be deemed to have been given (a) if delivered in person, when delivered;
(b) if delivered by facsimile, on the date of transmission if transmitted on a business day before 4:00 p.m. (New York
time) or, if not, on the next succeeding business day; (c) if delivered by overnight courier, one business day after delivery
to such courier properly addressed; or (d) if by registered or certified United States mail, four business days after deposit
in the United States mail, postage prepaid and properly addressed.

 

Notices shall be addressed
as follows:

 

If to Subordinated Creditor:

Platinum-Montaur Life Sciences LLC

Attention: Michael Nordlicht

152 West 57th Street, 4th Floor

New York, New York 10019

Facsimile: (212) 271-7855

If to Senior Creditor Agent:

Oxford Finance LLC

133 North Fairfax Street

Alexandria, Virginia 22314

Attention: Legal Department

Facsimile: (703) 519 5225

 

or in any case, to such other address as
the party addressed shall have previously designated by written notice to the serving party, given in accordance with this Section 9.

 

    	14

    	 

    

 

10.Successors
and Assigns. This Agreement shall inure to the benefit of, and shall be binding upon, the respective successors and assigns
of Senior Creditor Agent (for the benefit of Senior Creditor Agent and Senior Creditor), Subordinated Creditor and the Company.
To the extent permitted under the Senior Debt Documents, Senior Creditor Agent and Senior Creditor may, from time to time, without
notice to Subordinated Creditor, assign or transfer any or all of the Senior Debt or any interest therein to any Person and, notwithstanding
any such assignment or transfer, or any subsequent assignment or transfer, the Senior Debt shall, subject to the terms hereof,
be and remain Senior Debt for purposes of this Agreement, and every permitted assignee or transferee of any of the Senior Debt
or of any interest therein shall, to the extent of the interest of such permitted assignee or transferee in the Senior Debt, be
entitled to rely upon and be the third party beneficiary of the subordination provided under this Agreement and shall be entitled
to enforce the terms and provisions hereof to the same extent as if such assignee or transferee were initially a party hereto.

 

11.Relative
Rights; No Third Party Beneficiary. This Agreement shall define the relative rights of Senior Creditor Agent, Senior Creditor
and Subordinated Creditor. Nothing in this Agreement shall (a) impair, as among the Company, Senior Creditor Agent and Senior
Creditor and as between the Company and Subordinated Creditor, the obligation of the Company with respect to the payment of the
Senior Debt and the Subordinated Debt in accordance with their respective terms or (b) affect the relative rights of Senior
Creditor Agent, Senior Creditor or Subordinated Creditor with respect to any other creditors of the Company. This Agreement is
solely for the benefit of Senior Creditor Agent, Senior Creditor and Subordinated Creditor, and their respective successors and
assigns, and neither Company nor any other Persons are intended to be a third party beneficiary hereunder or to have any right,
benefit, priority or interest under, or because of the existence of, or to have any right to enforce, this Agreement.

 

12.Conflict.
In the event of any conflict between any term, covenant or condition of this Agreement and any term, covenant or condition of any
of the Senior Debt Documents or Subordinated Debt Documents, the provisions of this Agreement shall control and govern.

 

13.Headings.
The paragraph headings used in this Agreement are for convenience only and shall not affect the interpretation of any of the provisions
hereof.

 

14.Counterparts.
This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument. Delivery of an executed counterpart of a signature page to this Agreement by facsimile
or electronic “pdf” transmission shall be equally effective as delivery of a manually executed counterpart of a signature
page to this Agreement.

 

15.Severability.
In the event that any provision of this Agreement is deemed to be invalid, illegal or unenforceable by reason of the operation
of any law or by reason of the interpretation placed thereon by any court or governmental authority, the validity, legality and
enforceability of the remaining provisions of this Agreement shall not in any way be affected or impaired thereby, and the affected
provision shall be modified to the minimum extent permitted by law so as most fully to achieve the intention of this Agreement.

 

    	15

    	 

    

 

16.Continuation
of Subordination; Termination of Agreement. This Agreement shall remain in full force and effect and the provisions of
this Agreement shall continue to govern the relative rights and priorities of Senior Creditor Agent, Senior Creditor and Subordinated
Creditor even if all or part of the Senior Debt or the security interests securing the Senior Debt are subordinated, set aside,
avoided, invalidated, or disallowed, until the Subordination Termination Date after which this Agreement shall terminate without
further action on the part of the parties hereto. This Agreement shall be reinstated if at any time any payment of any of the Senior
Debt is rescinded or must otherwise be returned by any holder of Senior Debt or any representative of such holder.

 

17.Applicable
Law. This Agreement shall be governed by and shall be construed and enforced in accordance with the internal laws of the
State of New York, without regard to conflicts of law principles.

 

18.CONSENT
TO JURISDICTION. EACH OF SUBORDINATED CREDITOR AND, BY ITS ACKNOWLEDGMENT BELOW, THE COMPANY HEREBY CONSENTS TO THE JURISDICTION
OF ANY STATE OR FEDERAL COURT LOCATED WITHIN THE STATE OF NEW YORK AND IRREVOCABLY AGREES THAT, SUBJECT TO SENIOR CREDITOR AGENT’S
ELECTION, ALL ACTIONS OR PROCEEDINGS ARISING OUT OF OR RELATING TO THIS AGREEMENT SHALL BE LITIGATED IN SUCH COURTS. EACH OF SUBORDINATED
CREDITOR AND, BY ITS ACKNOWLEDGMENT BELOW, THE COMPANY EXPRESSLY SUBMITS AND CONSENTS TO THE JURISDICTION OF THE AFORESAID COURTS
AND WAIVES ANY DEFENSE OF FORUM NON CONVENIENS. EACH OF SUBORDINATED CREDITOR AND, BY ITS ACKNOWLEDGMENT BELOW, THE COMPANY HEREBY
WAIVES PERSONAL SERVICE OF ANY AND ALL PROCESS AND AGREES THAT ALL SUCH SERVICE OF PROCESS MAY BE MADE UPON IT BY CERTIFIED OR
REGISTERED MAIL, RETURN RECEIPT REQUESTED, ADDRESSED TO SUBORDINATED CREDITOR AND THE COMPANY AT THEIR RESPECTIVE ADDRESSES SET
FORTH IN THIS AGREEMENT.

 

19.WAIVER
OF JURY TRIAL. EACH OF SUBORDINATED CREDITOR, SENIOR CREDITOR AGENT AND, BY ITS ACKNOWLEDGMENT BELOW, THE COMPANY HEREBY
WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY
OF THE SUBORDINATED DEBT DOCUMENTS OR ANY OF THE SENIOR DEBT DOCUMENTS. EACH OF SUBORDINATED CREDITOR, SENIOR CREDITOR AGENT AND,
BY ITS ACKNOWLEDGMENT BELOW, THE COMPANY ACKNOWLEDGES THAT THIS WAIVER IS A MATERIAL INDUCEMENT TO ENTER INTO A BUSINESS RELATIONSHIP,
THAT EACH HAS RELIED ON THE WAIVER IN ENTERING INTO THIS AGREEMENT AND, IN THE CASE OF THE SENIOR CREDITOR AGENT AND THE COMPANY,
THE SENIOR DEBT DOCUMENTS, AND THAT EACH WILL CONTINUE TO RELY ON THE WAIVER IN THEIR RELATED FUTURE DEALINGS. EACH OF SUBORDINATED
CREDITOR, THE COMPANY AND SENIOR CREDITOR AGENT WARRANTS AND REPRESENTS THAT EACH HAS HAD THE OPPORTUNITY OF REVIEWING THIS JURY
WAIVER WITH LEGAL COUNSEL, AND THAT EACH KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS.

 

    	16

    	 

    

 

20.Representations
Regarding Subordinated Loan Agreement. Subordinated Creditor hereby represents and warrants to Senior Creditor Agent, for
the benefit of Senior Creditor Agent and Senior Creditor, that as of the date hereof: (a) it has executed and delivered the
Amendment to Subordinated Loan Agreement; (b) as of the date of this Agreement, the Draw Credit Maximum Amount (as defined
in the Subordinated Loan Agreement) is no less than $35,000,000 (of which $3,218,666.82 has been drawn) and may be increased pursuant
to Section 2.6 of the Subordinated Loan Agreement by an additional $15,000,000; and (c) no liens or other security interest
have been granted in favor of the Subordinated Creditor or any of its affiliates pursuant to any Subordinated Debt Document.

 

21.Consent
to Issuance of Warrants. The Subordinated Creditor hereby consents to the issuance of warrants to any Senior Creditor (or
any affiliate of any Senior Creditor) from time to time in accordance with the terms of the Senior Loan Agreement, notwithstanding
the share effective price of any such warrants.

 

(Signature page follows)

 

 

    	17

    	 

    

 

IN WITNESS WHEREOF,
Subordinated Creditor and Senior Creditor Agent have caused this Agreement to be executed as of the date first above written.

 

 

 

	 	SENIOR CREDITOR AGENT:
	 	 
	 	 
	 	OXFORD FINANCE LLC
	 	 
	 	By: 	/s/ Mark Davis	 
	 	Name:	Mark Davis	 
	 	Its:	Vice President-Finance, Treasurer and	 
	 	 	Secretary	 

 

 

 

Signature Page to Subordination Agreement (Navidea)

 

    	 

    	 

    

 

 

	 	SUBORDINATED CREDITOR
	 	 
	 	 
	 	PLATINUM-MONTAUR LIFE SCIENCES LLC
	 	 
	 	By: 	/s/ Joseph SanFilipo	 
	 	Name:	Joseph SanFilipo	 
	 	Its:	 CFO	 

 

 

 

 

 

Signature Page to Subordination Agreement (Navidea)

 

    	 

    	 

    

COMPANY ACKNOWLEDGMENT, CONSENT AND
AGREEMENT

 

Each of the undersigned
hereby acknowledges and consents to the execution, delivery and performance of the within and foregoing Subordination Agreement
among each of the holders of the Subordinated Debt and Senior Creditor Agent. Each of the undersigned further agrees to be bound
by the provisions of the within and foregoing Subordination Agreement as they relate to the relative rights, remedies and priorities
of the Senior Creditor Agent and Senior Creditor; provided, however, that nothing in the Subordination Agreement shall amend,
modify, change or supersede the respective terms of any of the Senior Debt Documents or the Subordinated Debt Documents as between
Senior Creditor Agent, Senior Creditor or the Subordinated Creditor, respectively, on the one hand, and any of the undersigned,
on the other hand.

 

[Signature pages follow]

 

    	 

    	 

    

IN WITNESS WHEREOF,
each of the undersigned has caused its duly authorized officers or other representatives to execute and deliver this Company Acknowledgment,
Consent and Agreement as of the date first written above.

 

 

	 	NAVIDEA BIOPHARMACEUTICALS, INC.
	 	 
	 	 
	 	By: 	/s/ Brent L. Larson	 
	 	Name:	 Brent L. Larson	 
	 	Its:	  EVP, CFO, Treasurer and Secretary	 

 

 

 

 

 

 

Signature Page to Subordination Agreement (Navidea)Exhibit 10.3

 

 

 

 

 

 

SECOND AMENDMENT TO LOAN AGREEMENT

 

 

This Second Amendment
to Loan Agreement (the “Second Amendment”) is made as of the 4th day of March, 2014, by and between NAVIDEA
BIOPHARMACEUTICALS, INC., a Delaware corporation (the “Borrower”), and PLATINUM-MONTAUR LIFE SCIENCES,
LLC, a Delaware limited liability company (the “Lender”).

 

WHEREAS, pursuant
to a Loan Agreement, dated as of July 25, 2012, by and between the Borrower and the Lender (the “Loan Agreement”),
the Lender extended a Term Loan to the Borrower; and

 

WHEREAS, the
Loan Agreement was amended as of June 25, 2013, in connection with a loan to the Borrower by General Electric Capital Corporation
(the “First Amendment”), and a Subordination Agreement of even date among the Borrower, the Lender and General
Electric Capital Corporation (the “GE Subordination Agreement”); and

 

WHEREAS, the
Borrower has entered into a Loan and Security Agreement dated as of March __, 2014 with Oxford Finance LLC (the “Oxford
Loan Agreement”), a portion of the proceeds of which will be applied to discharge Borrower’s Indebtedness to General
Electric Capital Corporation; and

 

WHEREAS, the
Borrower and the Lender desire to amend certain terms of the Loan Agreement to, among other things, reflect the discharge of Borrower’s
Indebtedness to General Electric Capital Corporation, the Borrower incurring new Indebtedness pursuant to the Oxford Loan Agreement,
the termination of the GE Subordination Agreement, and the entry into a Subordination Agreement among the Borrower, the Lender,
and Oxford Finance LLC (the “Oxford Subordination Agreement”), on the terms and conditions set forth herein;

 

NOW, THEREFORE,
in consideration of the foregoing and the covenants contained herein, and for other good and valuable consideration, the receipt
and adequacy of which are hereby acknowledged, the parties agree as follows:

 

Article
One

DEFINITIONS; REPRESENTATIONS; CONSENT

 

	Section 1.1	Terms Defined.

 

Unless otherwise defined
herein, capitalized terms used herein shall have the same meanings given in the Loan Agreement, as amended by the First Amendment.

 

	Section 1.2	Representations and Warranties of the Borrower.

 

1.2.1 The representations and warranties of the Borrower made in the Loan Documents
remain true and accurate and the covenants of the Borrower under the Loan Documents are hereby reaffirmed as of the date hereof.

 

1.2.2 The Borrower
has performed, in all material respects, all obligations to be performed by it to date under the Loan Documents and no Event of
Default exists thereunder or an event which, with the passage of time or giving of notice or both, would constitute an Event of
Default.

 

 

	 

	 

 

 

 

1.2.3 The execution,
delivery and performance of this Second Amendment and any and all documents and instruments relating hereto of even or approximate
date as this Amendment (collectively, and including the Second Amended Note (as defined below), the “Second Amendment
Documents”), are within the power and authority of the Borrower and are not in contravention of the Borrower’s
Certificate of Incorporation or Bylaws, or the terms of any other documents, instruments, agreements or undertakings to which the
Borrower is a party or by which the Borrower is bound. To the best of the Borrower’s knowledge, no approval of any person,
corporation, governmental body or other entity not provided herewith is a prerequisite to the execution, delivery and performance
by the Borrower of the Second Amendment Documents or any of the documents submitted to the Lender in connection with the Second
Amendment Documents, to ensure the validity or enforceability thereof.

 

1.2.4 When executed
on behalf of the Borrower, the Second Amendment Documents will constitute the legally binding obligations of the Borrower, enforceable
in accordance with their terms, subject to the effect of applicable bankruptcy, insolvency, reorganization, moratorium and other
similar laws now existing or hereafter enacted relating to or affecting the enforcement of creditors’ rights generally, and
the enforceability may be subject to limitations based on general principles of equity (regardless of whether such enforceability
is considered in a proceeding in equity or at law).

 

	Section 1.3	 Consent to Oxford Loan Documents

 

Upon
and as of the Effective Date, the Lender hereby consents to the terms and conditions of the Oxford Loan Agreement and the “Loan
Documents” as defined therein, each in substantially the forms attached hereto as Exhibit A, and the incurrence of
Indebtedness and granting of Liens contemplated thereby. 

 

Article
Two

Increase in Term Loan; AMENDMENTS

 

	Section 2.1	Amendments
to Defined Terms.

 

(a) Upon and as of
the Effective Date, the following paragraph shall be inserted at the top of the first page of the Loan Agreement:

 

“This instrument
and the indebtedness, rights and obligations evidenced hereby and any liens or other security interests securing such rights and
obligations are subordinate in the manner and to the extent set forth in that certain Subordination Agreement (as amended, restated,
supplemented or modified from time to time, the “Subordination Agreement”) dated as of March __, 2014, by and among
the Subordinated Creditor identified therein and Oxford Finance LLC in its capacity as agent for certain lenders (together with
its successors and assigns, “Senior Creditor Agent”), to certain indebtedness, rights, and obligations of Navidea Biopharmaceuticals,
Inc. to Senior Creditor Agent and Senior Creditor (as defined therein) and liens and security interests of Senior Creditor Agent
securing the same all as described in the Subordination Agreement; and each holder and transferee of this instrument, by its acceptance
hereof, irrevocably agrees to be bound by the provisions of the Subordination Agreement.”

 

(b) Upon and as of
the Effective Date, the definition of “Applicable Rate” in the Loan Agreement shall be amended to read in its entirety
as follows:

 

 

 

	2

	 

 

 

“Applicable
Rate” means the greatest of (i) the United States prime rate as reported in The Wall Street Journal plus 6.75%,
(ii) 10.0% and (iii) the highest rate of interest then payable by the Borrower pursuant to the Oxford Loan Documents plus
12.5 basis points (0.125%); provided, that, the Applicable Rate shall be adjusted immediately to correspond with
each change in the prime rate or the highest rate of interest then payable by the Borrower pursuant to the Oxford Loan Documents.

 

(c) Upon
and as of the Effective Date, the definition of “GECC Loan Agreement” in Section 1.1 of the Loan Agreement shall be
deleted in its entirety, and replaced by the following :

 

“Oxford
Loan Agreement” means the Loan and Security Agreement, dated as of March __, 2014, by and between the Borrower, the other
loan parties from time to time party thereto, Oxford Finance LLC, as administrative and collateral agent, and the lenders from
time to time party thereto, as it may be amended, restated, supplemented, refinanced or otherwise modified from time to time.

 

(d) Upon
and as of the Effective Date, the definition of “GECC Loan Documents” in Section 1.1 of the Loan Agreement shall be
deleted in its entirety, and replaced by the following:

 

“Oxford
Loan Documents” means the Oxford Loan Agreement and the “Loan Documents” referred to therein, as each may
be amended, restated, supplemented, refinanced or otherwise modified from time to time.

 

(e) Upon and as of
the Effective Date, the definition of “Permitted Liens” shall be amended to read in its entirety as follows:

 

“Permitted
Liens” mean (i) any Liens held by Lender or Affiliates of Lender at any time after the termination of the Subordination
Agreement, (ii) Liens for unpaid taxes that either are not yet delinquent, or do not constitute an Event of Default hereunder and
are the subject of a Permitted Contest, (iii) Liens securing Indebtedness incurred pursuant to the Oxford Loan Documents, (iv)
the interests of lessors under any lease of real property in the ordinary course of business, (v) Liens securing purchase money
Indebtedness or the interests of lessors under Capital Leases to the extent that such Liens or interests secure Permitted Purchase
Money Indebtedness, provided that (x) such Liens exist prior to the acquisition of, or attach substantially simultaneous with,
or within 20 days after, the acquisition, repair, improvement or construction of, such property financed by such Indebtedness and
(y) such Liens do not extend to any Property of a Loan Party other than the Property (and proceeds thereof) acquired or built,
or the improvements or repairs, financed by such Indebtedness,(vi) Liens arising by operation of law in favor of warehousemen,
landlords, carriers, mechanics, materialmen, or laborers, incurred in the ordinary course of Borrower’s business and not
in connection with the borrowing of money, and which Liens either (A) are for sums not yet delinquent, or (B) are the subject of
Permitted Contests, (vii) Liens arising from pledges or deposits made in the ordinary course of business in connection with obtaining
worker’s compensation or other unemployment insurance, (viii) Liens or pledged or deposits to secure performance of bids,
tenders, leases (other than capital leases), sales or other trade contracts incurred in the ordinary course of Borrower’s
business and not in connection with the borrowing of money, (ix) Liens granted as security for surety, customs, reclamation or
performance bonds, or judgment or appeal bonds, in each case in connection with obtaining
such bonds in the ordinary course of Borrower’s business, (x) Liens resulting from any judgment or award that is not an Event
of Default hereunder, (xi) Liens related to any Permitted Acquisition, to the extent such Liens encumber only the assets acquired
in such Permitted Acquisition, (xii) Liens of a collection bank on items in the course of collection arising under Section 4-208
of the UCC, (xiii) Liens arising by reason of zoning restrictions, easements, licenses, reservations, restrictions, covenants,
rights-of-way, encroachments, minor defects or irregularities in title (including leasehold title) and other similar encumbrances
on the use of real property that do not materially (x) impair the value or marketability of such real property or (y) interfere
with the ordinary conduct of the business conducted and proposed to be conducted at such real property; and (xiv) non-exclusive
licenses of the intellectual property of the Borrower or any Subsidiary of the Borrower that do not restrict the applicable licensor’s
ability to grant a lien on, assign or otherwise transfer such license or any intellectual property.

 

 

 

	3

	 

 

 

(f) Upon and as of
the Effective Date, the definition of “Subordination Agreement” in Section 1.1 of the Loan Agreement shall be deleted
in its entirety, and replaced by the following:

 

“Subordination
Agreement” means the Subordination Agreement, dated as of March __, 2014, between the Lender and Oxford Finance LLC,
and consented to by the Borrower and the Subsidiaries of the Borrower from time to time party thereto.

 

 

	Section 2.2	 Amendment to Section 2.2.

 

Upon and as of the Effective Date, Section
2.2(f) of the Loan Agreement shall be amended to read in its entirety as follows:

 

(f) Notwithstanding anything to the
contrary contained herein, the Lender shall have no obligation to fund any Draw hereunder upon and after the occurrence of an Event
of Default or an “Event of Default” under and as defined in the Oxford Loan Agreement.

 

	Section 2.3	 Amendment to Section 5.10.

 

Upon and as of the Effective Date, Section
5.10 of the Loan Agreement shall be amended to read in its entirety as follows:

 

The Borrower each Guarantor (a) has
an indefeasible interest in all personal property which it has an interest, free and clear of any Liens, except Permitted Liens,
and (b) has not agreed or consented to cause or permit in the future (upon the happening of a contingency or otherwise) any of
its property whether now owned or hereafter acquired to be subject to a Lien, except Permitted Liens and agreements contained under
the Oxford Loan Documents. Neither Borrower nor any Guarantor owns any real property.

 

 

	4

	 

 

 

		Section 2.4	 Amendment to Section 7.1.

 

Upon and as of the
Effective Date, Section 7.1(viii) of the Loan Agreement shall be amended to read in its entirety as follows:

 

(viii) The occurrence of any event
which allows the acceleration of the maturity of any Indebtedness in excess of the amount of $1,000,000 of Borrower and/or any
Guarantor on an aggregate basis (other than Indebtedness incurred pursuant to the Oxford Loan Documents);

 

	Section 2.5	Amendment to Section 7.1.

 

Upon and as of the
Effective Date, Section 7.1(x) of the Loan Agreement shall be amended to read in its entirety as follows:

 

(x) An event of default shall have
occurred under the Oxford Loan Documents, and as a result thereof the loans made under the Oxford Loan Documents have become due
prior to the stated maturity of such loans; and

 

	Section 2.6	Amendment and Restatement of Note.

 

 

Upon and as of the Effective Date, the Promissory
Note shall be amended and restated, in the form attached hereto as Exhibit B (the “Second Amended Note”),
and all references in the Loan Documents to the Note or Notes shall be deemed to mean and refer to the Second Amended Note.

 

 

Article
Three

CLOSING CONDITIONS

 

	Section 3.1	Closing Conditions.

 

The obligation of the
Lender to execute and deliver this Amendment is subject to fulfillment of the following conditions precedent:

 

(i) the Borrower shall
have executed and delivered to the Lender this Amendment and all other Amendment Documents applicable to it, including the Second
Amended Note;

 

(ii) all representations
and warranties of the Borrower shall be true and correct and no material adverse change shall have occurred in the business, condition
(financial or otherwise) or prospects of the Borrower, from the date of the most recent financial statements of the Borrower delivered
to the Lender;

 

 

 

	5

	 

 

 

(iii) the Lender shall
have received evidence of the repayment in full, and release of all liens securing, the Indebtedness of the Borrower and the Subsidiaries
of the Borrower to General Electric Credit Corporation;

 

(iv) the Lender shall
have received evidence of the execution and delivery of the Oxford Loan Agreement and the “Loan Documents” referred
to therein, and Oxford shall have committed to fund Indebtedness thereunder in a gross amount of not less than $30,000,000 contemporaneously
with this Amendment becoming effective; and

 

(v) The Borrower shall
have agreed to provide notice of certain financing activities to the Lender in form and substance reasonably satisfactory to the
Lender (the “Notice Letter”).

 

	Section 3.2	 Effective Date.

 

This Amendment shall
become effective as of the date first above written upon evidence satisfactory to the Lender that all of the foregoing closing
conditions have been satisfied (the “Effective Date”).

 

Article
Four

MISCELLANEOUS

 

	Section 4.1	 Loan Documents

 

The Borrower shall
deliver this Second Amendment, all other Second Amendment Documents and the Notice Letter, to the Lender and those documents shall
be included in the term the “Loan Documents” in the Loan Agreement. The provisions of the Loan Documents, as modified
herein, shall remain in full force and effect in accordance with their terms and are hereby ratified and confirmed.

 

	Section 4.2	 Survival of Representations and Warranties.

 

All agreements, representations
and warranties contained in the Loan Documents shall survive the execution and delivery of this Amendment, and any investigation
at any time made by or on behalf of the Lender.

 

	Section 4.3	 Expenses.

 

The Borrower agrees,
regardless of whether or not the transactions contemplated hereby shall be consummated, to pay all reasonable expenses incurred
by the Lender incident to such transactions in the preparation of documentation relating thereto, including without limitation
fees and disbursements of the Lender’s counsel incurred in connection with this Amendment and the Oxford Subordination Agreement.

 

	Section 4.4 	General.

 

The Borrower shall
execute and deliver such additional documents and instruments and shall do such other acts as the Lender may reasonably require
in order to implement this Amendment fully. This Amendment may be executed in counterparts by the Borrower and the Lender, each
of which shall be deemed an original but all of which together shall constitute one and the same agreement.

 

 

[Signature Page Follows]

 

 

 

	6

	 

 

 

 

IN WITNESS WHEREOF,
the undersigned have caused this Second Amendment to be executed by their duly authorized agents as of the date first above written.

 

Borrower:

 

NAVIDEA BIOPHARMACEUTICALS, INC.

 

 

By: /s/ Brent L. Larson 

Name: Brent L. Larson

Title: EVP, CFO, Treasurer and Secretary

 

 

 

 

 

Lender:

 

PLATINUM-MONTAUR LIFE SCIENCES, LLC 

 

 

By:/s/ Joseph SanFilippo 

Name: Joseph SanFilippo

Title: CFO

 

 

 

	7

	 

 

 

 

 

Exhibit A

 

[Oxford Loan Documents]

 

 

 

 

 

 

	 

	 

 

 

 

 

 

 

 

 

Exhibit B

 

[Second Amended Note]

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