Document:

Amended & Restated 1994 Long-Term Incentive Plan for Executives

 Exhibit (10)(uu) 
 MARSHALL & ILSLEY CORPORATION 
 AMENDED AND RESTATED 
 1994 LONG-TERM INCENTIVE PLAN FOR EXECUTIVES 
 as of December 15, 2005 
 1. PURPOSE OF THE PLAN. 
 The purpose of the Plan is to promote the best interests of Marshall & Ilsley Corporation and enhance shareholder value by attracting and retaining key personnel and providing such employees with an incentive
to put forth maximum effort for the continued success and growth of the Company. 
 2. DEFINITIONS. 
 (a) “Account” shall mean the account established and administered for the benefit of a Participant under the Plan if the Participant is awarded
Units. 
 (b) “Code” shall mean the Internal Revenue Code of 1986, as amended. 
 (c) “Committee” shall mean the Committee referenced in Paragraph 3 of the Plan. 
 (d) “Company” shall mean Marshall & Ilsley Corporation, a Wisconsin corporation. 
 (e) “Disability” shall mean long-term disability as defined in the Company’s long-term disability plan, as the same may be amended from
time to time. 
 (f) “Early Retirement” shall mean termination of employment with the Company, or a Subsidiary, but only if the
following requirements are met: (i) the Participant is age 55 or older and the sum of his age plus years of service with the Company or a Subsidiary equals or exceeds 65, (ii) the Participant executes an agreement regarding
confidentiality, non-competition, non-solicitation and/or non-disparagement in the form presented to him by the Company, and (iii) the Participant executes a release of employment-related claims after termination of employment in the form
presented to him by the Company, and does not revoke said release during the applicable rescission period. 
 (g) “Employees” shall
mean those individuals who are executive officers or senior managers of the Company or its Subsidiaries. 
 (h) “Market Price”
shall mean the closing sale price of a Share on the New York Stock Exchange as reported in the Midwest Edition of the Wall Street Journal, or such other market price as the Committee may determine in conformity with pertinent law and regulations of
the Treasury Department. 

 (i) “1934 Act” shall mean the Securities Exchange Act of 1934, as amended. 
 (j) “Participant” shall mean an Employee designated by the Committee to be a participant in the Plan. 
 (k) “Plan” shall mean the Amended and Restated 1994 Long-Term Incentive Plan for Executives of the Company. 
 (l) “Share” or “Shares” shall mean the $ 1.00 par value common stock of the Company. 
 (m) “Subsidiary” shall mean any corporation, partnership, limited liability company or other business entity which, directly or indirectly
through one or more intermediaries, is controlled by the Company. The term “control” means the power, directly or indirectly, to vote 50% or more of the securities which have ordinary voting power in the election of directors (or
individuals filling any analogous positions). 
 (n) “Triggering Event” shall mean the first to occur of the following: 

(i) The acquisition by any individual, entity or “group” (within the meaning of Section 13(d)(3) or 14(d)(2) of the
Securities Exchange Act of 1934, as amended (the “Exchange Act”)) of beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act) of thirty-three percent (33%) or more of either (A) the then
outstanding shares of common stock of the Company (the “Outstanding Company Common Stock”) or (B) the combined voting power of the then outstanding voting securities of the Company entitled to vote generally in the election of
directors (the “Outstanding Company Voting Securities”); provided, however, that the following acquisitions of common stock shall not constitute a Triggering Event: (A) any acquisition directly from the Company
(excluding an acquisition by virtue of the exercise of a conversion privilege or by one person or a group of persons acting in concert), (B) any acquisition by the Company, (C) any acquisition by any employee benefit plan (or related
trust) sponsored or maintained by the Company or any corporation controlled by the Company or (D) any acquisition by any corporation pursuant to a reorganization, merger, statutory share exchange or consolidation which would not be a Triggering
Event under paragraph (iii) of this Section 2(m); or 
 (ii) Individuals who, as of the date hereof, constitute the
Board (the “Incumbent Board”) cease for any reason to constitute at least a majority of the Board; provided, however, that any individual becoming a director subsequent to the date hereof whose election, or nomination for election by the
Company’s shareholders, was approved by a vote of at least a majority of the directors then comprising the Incumbent Board shall be considered as though such individual were a member of the Incumbent Board, but 

 
excluding, for this purpose, any such individual whose initial assumption of office occurs as a result of either an actual or threatened “election
contest” or other actual or threatened “solicitation” (as such terms are used in Rule 14a-11 of Regulation 14A promulgated under the Exchange Act) of proxies or consents by or on behalf of a person other than the Incumbent Board; or

 (iii) Consummation of a reorganization, merger, statutory share exchange or consolidation, unless, following such
reorganization, merger, statutory share exchange or consolidation, (A) more than two-thirds (2/3) of, respectively, the then outstanding shares of common stock of the corporation resulting from such reorganization, merger, statutory share
exchange or consolidation and the combined voting power of the then outstanding voting securities of such corporation entitled to vote generally in the election of directors is then beneficially owned, directly or indirectly, by all or substantially
all of the individuals and entities who were the beneficial owners, respectively, of the Outstanding Company Common Stock and Outstanding Company Voting Securities immediately prior to such reorganization, merger, statutory share exchange or
consolidation in substantially the same proportions as their ownership, immediately prior to such reorganization, merger, statutory share exchange or consolidation, (B) no person (excluding the Company, any employee benefit plan (or related
trust) of the Company or such corporation resulting from such reorganization, merger, statutory share exchange or consolidation and any person beneficially owning, immediately prior to such reorganization, merger, statutory share exchange or
consolidation, directly or indirectly, thirty-three percent (33%) or more of the Outstanding Company Common Stock or Outstanding Voting Securities, as the case may be) beneficially owns, directly or indirectly, thirty-three percent
(33%) or more of, respectively, the then outstanding shares of common stock of the corporation resulting from such reorganization, merger, statutory share exchange or consolidation or the combined voting power of the then outstanding voting
securities of such corporation, entitled to vote generally in the election of directors and (C) at least a majority of the members of the board of directors of the corporation resulting from such reorganization, merger, statutory share exchange
or consolidation were members of the Incumbent Board at the time of the execution of the initial agreement providing for such reorganization, merger or consolidation; or 
 (iv) Consummation of (A) a complete liquidation or dissolution of the Company or (B) the sale or other disposition of all or
substantially all of the assets of the Company, other than to a corporation, with respect to which following such sale or other disposition, (1) more than two-thirds (2/3) of, respectively, the then outstanding shares of common stock of
such corporation and the combined voting power of the then outstanding voting securities of such corporation entitled to vote generally in the election of directors is then beneficially owned, directly or indirectly, by all or substantially all of
the individuals and entities who were the beneficial owners, respectively, of the Outstanding Company Common Stock and Outstanding Company Voting Securities immediately prior to such sale or other disposition in substantially the same proportion as
their ownership, 

 
immediately prior to such sale or other disposition, of the Outstanding Company Common Stock and Outstanding Company Voting Securities, as the case may be,
(2) no person (excluding the Company and any employee benefit plan (or related trust) of the Company or such corporation and any person beneficially owning, immediately prior to such sale or other disposition, directly or indirectly,
thirty-three percent (33%) or more of the Outstanding Company Common Stock or Outstanding Company Voting Securities, as the case may be) beneficially owns, directly or indirectly, thirty-three percent (33%) or more of, respectively, the
then outstanding shares of common stock of such corporation or the combined voting power of the then outstanding voting securities of such corporation entitled to vote generally in the election of directors and (C) at least a majority of the
members of the board of directors of such corporation were members of the Incumbent Board at the time of the execution of the initial agreement or action of the Board providing for such sale or other disposition of assets of the Company. 

(o) “Unit” shall mean a bookkeeping entry used by the Company to record and account for the grant of an award under the Plan denominated in
Shares until such time as the award is paid, cancelled, forfeited or terminated, as the case may be. 
 3. ADMINISTRATION OF THE PLAN. 
 (a) The Plan shall be administered by the Compensation and Human Resources Committee of the Board of Directors of the Company. The Committee shall consist
of not less than three members of the Board of Directors of the Company and shall be so constituted as to permit the Plan to comply with Rule 16b-3 under the 1934 Act, as such rule is currently in effect or as hereafter modified or amended,
Section 162(m) of the Code, or any successor rule or other statutory or regulatory requirements. 
 (b) The Committee shall have sole
authority in its discretion, but always subject to the express provisions of the Plan, to determine the Employees who will be Participants; the number of Units which will be credited to each Account in the case of Employees who are awarded Units;
the dollar amounts to be earned by certain Employees of a Subsidiary or division of the Company upon the attainment of performance goals tied to the performance of the employing Subsidiary or division of the Company; the performance criteria for
earning the Units credited to each Account, or dollar amounts in the case of Employees of a Subsidiary or division of the Company; and the period of time to which the performance criteria will be applied. The Committee shall have sole authority in
its discretion to interpret the plan; to prescribe, amend and rescind rules and regulations pertaining to the Plan; to determine the terms and provisions of the respective awards to Participants; and to make all other determinations and
interpretations deemed necessary or advisable for the administration of the Plan. The Committee’s determination of the foregoing matter shall be conclusive and binding on the Company, all Employees, all Participants and all other persons.

 4. ELIGIBILITY. 
 Only Employees shall be eligible to be Participants under the Plan. In determining which Employees will be Participants and the amount of the award hereunder, the Committee may take into account the nature of the services rendered by the
respective Employees, their present and potential contributions to the success of the Company, its Subsidiaries or divisions, and other such factors as the Committee in its discretion shall deem relevant. In all events, awards made to the Chairman
of the Board, Chief Executive Officer, Chief Operating Officer or Chief Financial Officer of the Company will be denominated in terms of Units. An Employee who has been granted an award under the Plan may be granted additional awards under the Plan
if the Committee shall so determine. The Company shall effect the granting of awards hereunder in such manner as the Committee determines. No award may be granted under the Plan to a member of the Committee. In addition, any payment made to an
Employee of a Subsidiary or division that is tied to the performance of that Subsidiary or division and, at the time of the grant was denominated in cash, shall not exceed a maximum of $1,000,000 for each award period. 
 5. ESTABLISHMENT OF ACCOUNTS. 
 The Company shall establish
on its books of account a separate Account for each Participant awarded Units, which shall be used for the purpose of determining the compensation to which such Participant from time to time may be entitled hereunder. There shall be recorded in such
Participant’s Account the number of Units from time to time credited to the Participant by the Committee or pursuant to Paragraph 8 hereof. In no event will more than 3,000,000 Units, subject to adjustment under Paragraph 10 hereof, be granted
under the Plan (excluding Units credited in lieu of dividends under Paragraph 8 hereof). No more that 600,000 Units will be granted to any one individual (again excluding Units credited in lieu of dividends and subject to adjustment under Paragraph
10) during the term of the Plan. Accounts shall be maintained solely for accounting purposes, and no assets of the Company shall be segregated or subject to any trust for any Participant’s benefit by reason of the establishment of the
Participant’s Account. In addition, no Participant shall acquire any rights as a shareholder of the Company, including the right to vote with respect to any matter before the shareholders of the Company or to receive dividends payable on the
common stock, or, except as is specifically provided otherwise herein, any other rights, by reason of the establishment of the Participant’s Account. 
 6. PERFORMANCE CRITERIA. 
 The Committee shall establish performance criteria which will govern whether and to what extent
Participants will receive a pay-out of their Accounts, or, in the case of certain Employees of a Subsidiary or a division of the Company, the dollar amount, if any, to be paid to such Participant. The criteria among which the Committee may choose in
establishing performance criteria are one or more of earnings per share, net income, revenues, return on average assets, return on average equity, total shareholder return or cost control of the Company and/or one or more of its Subsidiaries,
divisions, or any other entity in which the Company owns 

 
more than 50% of the interests entitled to vote. The length of the performance period, the performance objectives to be achieved during the performance
period (including defining the above terms, and if deemed appropriate, the exclusion of extraordinary items or any other adjustments considered proper), and the measure of whether and to what degree such objectives have been attained shall be
conclusively determined by the Committee. No payment of awards under this Plan shall be made until the Committee certifies that the performance criteria to which such awards were subject have been met. Even though the performance criteria have been
met, the Committee expressly reserves the right to reduce or eliminate entirely any award if it determines it is in the best interests of the Company to do so. 
 7. PAYMENT OF AWARDS. 
 Awards earned under the Plan will be paid in cash. If all or any portion of a Participant’s award is
not deductible by the Company for federal income tax purposes because of limitations contained in Section 162(m) of the Code, the Committee may, in its sole discretion, require that the nondeductible portion be deferred to the Company’s
Executive Deferred Compensation Plan. In addition, if the timing of the payment of an award would result in a Participant being subject to a penalty under Section 409A of the Code, the payments shall be delayed for the minimum amount of time
required to avoid such penalty. The Participant shall receive interest on the delayed payment at a taxable money market rate as determined by the Committee in its sole discretion, or, if such money is held in a Rabbi Trust, the Participant shall
receive interest equal to the amount earned on the funds while they were held by the Rabbi Trust. 
 8. DIVIDENDS AND DIVIDEND EQUIVALENTS. 
 At such time as dividends are paid on Shares, an Account of a Participant shall be credited with that number of additional Units equal to the
product of (a) the number of Units then in the Account times (b) the amount of the dividend per Share divided by (c) the Market Price of a Share on the date a dividend is paid. 
 9. TERMINATION OF EMPLOYMENT. 
 (a) Any Participant whose
employment with the Company, a Subsidiary or division is terminated due to retirement on or after such Participant’s normal retirement date (as defined in the M&I Retirement Program or any successor thereto), Early Retirement or Disability,
shall continue as a Participant in the Plan as to awards previously made (and any dividends or dividend equivalents earned in connection therewith), but shall not be entitled to any new awards after the date of retirement, early retirement or
long-term disability. 
 (b) Any Participant whose employment with the Company, a Subsidiary or division is terminated due to or death or any
Participant who dies after Retirement, as defined in subparagraph (a), above, Early Retirement or Disability, but while he still is a Participant in the Plan, shall continue as a Participant in the 

 
Plan as to awards previously made (and any dividends or dividend equivalents earned in connection therewith) until the close of the calendar year in which
the Participant dies, unless the Committee decides to provide otherwise at the time an award is made. In such cases, the Committee will determine if and to what extent the performance criteria it established have been met as of the close of the
calendar year. Based on this determination, a Participant, or, in the case of death, his beneficiary as determined pursuant to Paragraph 12, hereof, shall receive a prorated award within 90 days of the end of the calendar year based on a fraction,
the numerator of which is the number of days from the beginning of the award period to the date of death or disability and the denominator of which is the total number of days in the award period. 
 (c) If a Participant’s employment is terminated for any reason other than those specified in subparagraphs (a) and (b), above, his
participation in the Plan shall immediately cease and he shall not be entitled to any award under the Plan, unless the Committee, in its sole discretion, determines otherwise. 
 (d) Notwithstanding the foregoing, if (i) a Participant’s employment is terminated as a result of, or in anticipation of, a Triggering Event,
or (ii) a Participant’s employment is not terminated, but a Triggering Event occurs, a Participant shall receive an amount equal to the amount he would be entitled to receive at the close of the performance period based on the extent to
which the performance criteria set by the Committee have been met as of the date of the Triggering Event, unless the Committee decides to provide otherwise at the time an award is made. Payment of the amount to which the Participant is entitled
hereunder shall be made within 30 days after the occurrence of the Triggering Event. Notwithstanding the foregoing, if the timing of the payment of an award would result in a Participant being subject to a penalty under Section 409A of the
Code, the payments shall be delayed for the minimum amount of time required to avoid such penalty. The Participant shall receive interest on the delayed payment at a taxable money market rate as determined by the Committee in its sole discretion,
or, if such money is held in a Rabbi Trust, the Participant shall receive interest equal to the amount earned on the funds while they were held by the Rabbi Trust. 
 (e) The Plan does not confer upon any Participant any right with respect to continuation of employment by the Company, a Subsidiary or division, nor shall it interfere in any way with the right of the Company, any
Subsidiary or a division to terminate any Participant’s employment at any time. 
 10. ADJUSTMENT PROVISIONS. 
 If the Company shall effect a subdivision or consolidation of Shares or other capital readjustment, the payment of a stock dividend, or other increase or
reduction in the number of Shares outstanding, or shall effect a spin-off, split-off, or other distribution of assets to shareholders, without receiving consideration therefor in money, services or property, the number of Units in each Account and
the number of Shares available for payment of awards hereunder shall be appropriately adjusted by the Committee. 

 11. NONASSIGNABILITY. 
 No Accounts or any payment under the Plan shall be subject in any manner to alienation, anticipation, sale, transfer (except by will or the laws of descent and distribution), assignment, pledge, or encumbrance. Any
attempt to alienate, sell, transfer, assign, pledge or otherwise encumber any Account or any payment under the Plan shall be void and of no legal effect. 
 12. BENEFICIARY DESIGNATION. 
 If a Participant dies prior to the distribution to him of all amounts payable to him under the Plan,
the amounts otherwise distributable to the Participant if living, shall be distributed to his designated beneficiary or beneficiaries. All beneficiary designations shall be made in the form prescribed by the Committee from time to time and shall be
delivered to the Secretary of the Company. If there is no effective beneficiary designation on file at the time of the Participant’s death, distribution of amounts otherwise payable to the deceased Participant under the Plan shall be made to
his Estate. If the beneficiary designated by the Participant shall survive the Participant but die before receiving all distributions hereunder, all amounts otherwise payable to the deceased beneficiary shall be paid to such deceased
beneficiary’s Estate unless the Participant’s beneficiary designation provides otherwise. The Company shall have no responsibility with respect to the validity of any beneficiary designation made by a Participant and shall be fully
protected if it acts thereon in good faith. 
 13. TAXES. 
 The Company shall be entitled to pay or withhold the amount of any tax which it believes is required as a result of the payment of any amounts under the Plan, and the Company may defer making payments hereunder until
arrangements satisfactory to it have been made with respect to any such withholding obligations. The Company shall have the right to rely on a written opinion of legal counsel, which may be independent legal counsel or legal counsel regularly
employed by the Company, if any question should arise as to the payment or withholding of taxes. 
 14. EFFECTIVENESS OF THE PLAN. 
 The Plan became effective upon approval by the Company’s Executive Compensation Committee and Board of Directors on March 30, 1994, subject to
ratification of the Plan by the vote of the holders of a majority of the Shares present or represented and entitled to vote at an annual or special meeting of the Company duly called and held which vote was received on August 23, 1994. An
initial set of amendments hereto were approved by the Board of Directors on February 12, 1998, subject to approval at the April 28, 1998 Annual Meeting of shareholders, which approval was obtained. An additional set of amendments hereto
were approved by the 

 
Board of Directors on February 20, 2003, subject to approval at the April 22, 2003 Annual Meeting of shareholders. If shareholder approval is not
obtained, any awards previously made at the December 19, 2002 meeting of the Committee will be void and of no further effect. 
 15. TERMINATION AND
AMENDMENT. 
 The Plan may be terminated, modified or amended by the Company’s Board of Directors, provided, however, that any
modification or amendment which would, under applicable law or other regulatory provisions require shareholder approval and any amendment to increase the number of Units available for grant under the Plan shall be subject to shareholder approval and
provided, further, that no termination, modification or amendment of the Plan may, without the consent of a Participant, adversely affect the rights of such Participant in any outstanding award, other than a termination because the requisite
shareholder approval is not obtained. In such event, any awards made subject to the consent of the shareholders shall be void and of no further effect. 
 16. GOVERNING LAW. 
 The Plan shall be construed, administered and governed in all respects under and by the applicable laws of the
State of Wisconsin, without regard to its conflicts of law provisions.Form of Change of Control Agreement

 Exhibit 10.13 
  

								
	 Name
	 	 Title
	 	 Percentage of
 Base Salary
	 	 	 Number of Months
 for COBRA

	Colin Broom M.D.	 	Vice President, Chief Scientific Officer	 	100	%	 	12 months
	Thomas F. Doyle	 	Vice President, General Counsel and Secretary	 	150	%	 	18 months
	Vincent J. Milano	 	Vice President, Chief Financial Officer and Treasurer	 	150	%	 	18 months
	Joshua Tarnoff	 	Vice President, Chief Commercial Officer	 	100	%	 	12 months

 CHANGE OF CONTROL AGREEMENT 
 THIS CHANGE OF CONTROL AGREEMENT (the “Agreement”), is made on this          day of
            ,             , by and between VIROPHARMA INCORPORATED (the “Company”)
and              (the “Employee”). 
 WHEREAS, the
Employee serves as an employee of the Company; and 
 WHEREAS, the Company and the Employee desire to establish certain protections for the
Employee in the event of Employee’s termination of employment under the circumstances described herein. 
 NOW, THEREFORE, in
consideration of the foregoing and the mutual covenants and promises contained herein, and intending to be bound hereby, the parties agree as follows: 
 SECTION 1 Definitions. As used herein: 
 1.1. “Base Salary” means, as of any given date, the annual base
rate of salary payable to the Employee by the Company, as then in effect; provided, however, that in the case of a resignation by the Employee for the Good Reason described in Section 1.7.4, “Base Salary” will mean the annual
base rate of salary payable to the Employee by the Company, as in effect immediately prior to the reduction giving rise to the Good Reason. 
 1.2. “Board” means the Board of Directors of the Company. 
 1.3. “Cause” means fraud,
embezzlement, or any other serious criminal conduct that adversely affects the Company committed intentionally by the Employee in connection with Employee’s employment or the performance of Employee’s duties as an officer or director of
the Company or the Employee’s conviction of, or plea of guilty or nolo contendere to, any felony. 
 1.4. “Change of
Control” means the happening of an event, which shall be deemed to have occurred upon the earliest to occur of the following events: 
 1.4.1. the date the stockholders of the Company (or the Board, if stockholder action is not required) approve a plan or other arrangement pursuant to which the Company will be dissolved or liquidated; 
 1.4.2. the date the stockholders of the Company (or the Board, if stockholder action is not required) approve a definitive agreement to
sell or otherwise dispose of all or substantially all of the assets of the Company; 

 1.4.3. the date the stockholders of the Company (or the Board, if stockholder action is
not required) and the stockholders of the other constituent corporations (or their respective boards of directors, if and to the extent that stockholder action is not required) have approved a definitive agreement to merge or consolidate the Company
with or into another corporation, other than, in either case, a merger or consolidation of the Company in which holders of shares of the Company’s voting capital stock immediately prior to the merger or consolidation will have more than 50% of
the ownership of voting capital stock of the surviving corporation immediately after the merger or consolidation (on a fully diluted basis), which voting capital stock is to be held in the same proportion (on a fully diluted basis) as such
holders’ ownership of voting capital stock of the Company immediately before the merger or consolidation; 
 1.4.4. the
date any entity, person or group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act), other than (i) the Company, or (ii) any of its subsidiaries, or (iii) any employee benefit plan (or related
trust) sponsored or maintained by the Company or any of its subsidiaries, or (iv) any affiliate (as such term is defined in Rule 405 promulgated under the Securities Act) of any of the foregoing, shall have acquired beneficial ownership of, or
shall have acquired voting control over, 50% or more of the outstanding shares of the Company’s voting capital stock (on a fully diluted basis), unless the transaction pursuant to which such person, entity or group acquired such beneficial
ownership or control (i) resulted from the original issuance by the Company of shares of its voting capital stock, (ii) was approved by at least a majority of Directors who were either members of the Board on the date that this Agreement
was originally adopted by the Board or members of the Board for at least twelve (12) months before the date of such approval and (iii) does not otherwise constitute a Change of Control pursuant to Section 1.4.3 of this Agreement;

 1.4.5. the date the Board determines (in its sole discretion) that based on then-currently available information, the
events described in Section 1.4.4 are reasonably likely to occur; or 
 1.4.6. the first day after the date of this
Agreement when members of the Board (each a “Director”) are elected such that there is a change in the composition of the Board such that a majority of Directors have been members of the Board for less than twelve (12) months, unless
the nomination for election of each new Director who was not a Director at the beginning of such twelve (12) month period was approved by a vote of at least sixty percent (60%) of the Directors then still in office who were Directors at
the beginning of such period; 
 provided, however, for purposes of determining the precise date of any Change of Control, an event described above
will be deemed to have occurred on the date on which the last condition required for the consummation of that event is fulfilled or otherwise completed. 
 1.5. “Code” means Internal Revenue Code of 1986, as amended. 
 1.6.
“Disability” means the Employee’s inability, by reason of any physical or mental impairment, to substantially perform Employee’s regular duties as contemplated by this Agreement, as determined by the Board in its sole
discretion (after affording the Employee the opportunity to present Employee’s case), which inability is reasonably contemplated to continue for at least one year from its commencement and at least 90 days from the date of such determination.

 1.7. “Good Reason” means, without the Employee’s prior written consent, any of the following: 
 1.7.1. a change in the Employee’s role such that his or her authority, duties or responsibilities are not substantially equivalent to
the Employee’s authority, duties or responsibilities in effect immediately prior to such change; 
 1.7.2. the location
of the facility at which Employee is required to perform his or her duties is more than 50 miles from Exton, Pennsylvania, unless such new location does not increase the Employee’s commuting time; 
 1.7.3. a reduction of five percent (5%) or more in either of the Employee’s Base Salary or the amount of the Employee’s
Target Bonus; 

 1.7.4. the Company’s failure to pay or make available any material payment or
benefit due under this Agreement or any other material breach by the Company of this Agreement. 
 However, the foregoing events or conditions will
constitute Good Reason only if (A) such event or condition occurs during the period commencing on the date of a Change of Control and continuing for twelve consecutive months thereafter and (B) the Employee provides the Company with
written objection to the event or condition within 60 days following the occurrence thereof, the Company does not reverse or otherwise cure the event or condition within 30 days of receiving that written objection and the Employee resigns
Employee’s employment within 90 days following the expiration of that cure period. 
 1.8. “Release” means a release
substantially identical to the one attached hereto as Exhibit A. 
 1.9. “Target Bonus” means, with respect to any year, the
target amount of the annual bonus that would be payable to the Employee with respect to that year, whether under an employment or incentive agreement, under any bonus plan or policy of the Company or otherwise, assuming that all applicable
performance goals are met and conditions to the payment of such bonus are satisfied. 
 SECTION 2 Certain Terminations Following a Change of Control.
If the Employee’s employment with the Company ceases within the twelve (12) month period following the date of a Change of Control as a result of a termination by the Company without Cause, a resignation by the Employee for Good Reason or
due to Employee’s death or Disability, then subject to Section 4 and Section 5: 
 2.1 the Company will make a
lump sum cash payment to the Employee of all accrued but unpaid compensation through the date of such termination; 
 2.2 the
Company will make a lump sum cash payment to the Employee equal to % of the Employee’s Base Salary as in effect on such date (without taking into effect any reduction described in Section 1.7.3 above); and 
 2.3 for a period of              months commencing from the date of the
Employee’s termination of employment, the Company will waive all applicable premiums otherwise due for any group health continuation coverage elected by the Employee or Employee’s spouse or eligible dependents under COBRA (29 U.S.C.
§§ 1161-1169) to the extent the Company would have paid such premiums for Employee during Employee’s term of employment with the Company; 
 provided, however, that if the Company’s obligation to make the payments provided for in clause 2.1 above arises due to the Employee’s death or Disability, the cash payments described in clause 2.1 will be offset by the
amount of benefits paid to the Employee (or Employee’s representative(s), heirs, estate or beneficiaries) pursuant to the life insurance or disability plans, policies or arrangements of the Company by virtue of Employee’s death or
Disability (including, for this purpose, only that portion of such life insurance or disability benefits funded by the Company or by premium payments made by the Company). The payments and benefits described in this section are in lieu of (and not
in addition to) any other severance plan, fund, agreement or other arrangement maintained by the Company. 
 SECTION 3 Parachute Payments. Payments
under Section 2 shall be made without regard to whether the deductibility of such payments (or any other payments) would be limited or precluded by Section 280G of the Internal Revenue Code of 1986 (the “Code”) and without regard
to whether such payments would subject Employee to the federal excise tax levied on certain “excess parachute payments” under Section 4999 of the Code; provided, however, that if the Total After-Tax Payments (as defined below)
would be increased by limitation or elimination of any amount payable under Section 2, then the amount payable under such sections will be reduced to the extent necessary to maximize the Total After-Tax Payments. The determination of whether
and to what extent such payments are required to be reduced in accordance with the preceding sentence will be made at the Company’s expense by an independent, certified public accounting firm selected by the Board. In the event of any
underpayment or overpayment under Section 2 (as determined after application of this Section 8), the amount of such underpayment or overpayment will be immediately paid by the Company to Employee or refunded by Employee to the Company, as
the case may be, with interest at the applicable federal rate provided for in Section 7872(f)(2) of the Code. For purposes of this Section 3, “Total After-Tax Payments” means the total of all “parachute payments” (as
that 

 term is defined in Section 280G(b)(2) of the Code) made to or for the benefit of Employee (whether made hereunder or
otherwise), after reduction for all applicable federal taxes (including, without limitation, the tax described in Section 4999 of the Code). 
 SECTION
4 Timing of Payments Following Termination. Notwithstanding any provision of this Agreement, the payments and benefits described in Section 2 (other than any amounts payable pursuant to Section 2(a)) are conditioned on the
Employee’s execution and delivery to the Company of the Release in a manner consistent with the Older Workers Benefit Protection Act and any similar state law that is applicable. The amounts described in Sections 2.1, and 2.2 (as applicable)
will be paid in a lump sum, as soon as the Release becomes irrevocable following the Employee’s execution and delivery of the Release. 
 SECTION 5
Miscellaneous. 
 5.1. No Liability of Officers and Directors for Severance Upon Insolvency. Notwithstanding any other provision
of the Agreement and intending to be bound by this provision, the Employee hereby (a) waives any right to claim payment of amounts owed to her, now or in the future, pursuant to this Agreement from directors or officers of the Company if the
Company becomes insolvent, and (b) fully and forever releases and discharges the Company’s officers and directors from any and all claims, demands, liens, actions, suits, causes of action or judgments arising out of any present or future
claim for such amounts. 
 5.2. Successors and Assigns. This Agreement shall inure to the benefit of and be binding upon the Company
and Employee and their respective successors, executors, administrators, heirs and/or permitted assigns; provided, however, that neither Employee nor the Company may make any assignments of this Agreement or any interest herein, by operation
of law or otherwise, without the prior written consent of the other party, except that, without such consent, the Company may assign this Agreement to any successor to all or substantially all of its assets and business by means of liquidation,
dissolution, merger, consolidation, transfer of assets, or otherwise. 
 5.3. Governing Law. This Agreement shall be governed by and
construed in accordance with the laws of the Commonwealth of Pennsylvania without regard to the application of the principles of conflicts of laws. 
 5.4. Enforcement. Any legal proceeding arising out of or relating to this Agreement will be instituted in the United States District Court for the Eastern District of Pennsylvania, or if that court does not have or will not accept
jurisdiction, in any court of general jurisdiction in the Commonwealth of Pennsylvania, and the Employee and the Company hereby consent to the personal and exclusive jurisdiction of such court(s) and hereby waive any objection(s) that they may have
to personal jurisdiction, the laying of venue of any such proceeding and any claim or defense of inconvenient forum. 
 5.5. Waivers;
Separability. The waiver by either party hereto of any right hereunder or any failure to perform or breach by the other party hereto shall not be deemed a waiver of any other right hereunder or any other failure or breach by the other party
hereto, whether of the same or a similar nature or otherwise. No waiver shall be deemed to have occurred unless set forth in a writing executed by or on behalf of the waiving party. No such written waiver shall be deemed a continuing waiver unless
specifically stated therein, and each such waiver shall operate only as to the specific term or condition waived. Whenever possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable
law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or
the effectiveness or validity of any provision in any other jurisdiction, and this Agreement will be reformed, construed and enforced in such jurisdiction as if such invalid, illegal or unenforceable provision had never been contained herein.

 5.6. Notices. All notices and communications that are required or permitted to be given hereunder shall be in writing and shall be
deemed to have been duly given when delivered personally or upon mailing by registered or certified mail, postage prepaid, return receipt requested, as follows: 
 If to the Company, to: 
 ViroPharma Incorporated 
 405 Eagleview Boulevard 
 Exton, PA 19341 
 Attn: General Counsel 
 Fax: (610) 458-7830 
 If to Employee, to: 
 [                    ] 

 or to such other address as may be specified in a notice given by one party to the other party hereunder. 
 5.7. Entire Agreement; Amendments. This Agreement and the attached exhibit contain the entire agreement and understanding of the parties relating
to the provision of severance benefits upon termination in connection with a Change of Control, and merges and supersedes all prior and contemporaneous discussions, agreements and understandings of every nature relating to that subject. 

5.8. Withholding. The Company will withhold from any payments due to Employee hereunder, all taxes, FICA or other amounts required to be
withheld pursuant to any applicable law. 
 5.9. Headings Descriptive. The headings of sections and paragraphs of this Agreement are
inserted for convenience only and shall not in any way affect the meaning or construction of any provision of this Agreement. 
 5.10.
Counterparts and Facsimiles. This Agreement may be executed, including execution by facsimile signature, in one or more counterparts, each of which shall be deemed an original, and all of which together shall be deemed to be one and the same
instrument. 
 5.11. No Duty to Mitigate. Employee shall not be required to mitigate damages or the amount of any payments provided
for under this Agreement by seeking other employment or otherwise, nor (except as otherwise provided in Section 2) will any payment or benefit hereunder be subject to offset or reduction in the event Employee does mitigate. 
 IN WITNESS WHEREOF, the parties hereto have executed this Agreement on the date and year first above written. 
  

	
	VIROPHARMA INCORPORATED
	  
  

	 By:
 Title:

	
	Employee
	  

 Exhibit A 
 Release and Non-Disparagement Agreement 
 THIS RELEASE AND NON-DISPARAGEMENT AGREEMENT (this
“Release”) is made as of the              day of              ,
             by and between              (the “Employee”) and VIROPHARMA,
INCORPORATED (the “Company”). 
 WHEREAS, the Employee’s employment as an executive of the Company has terminated; and

 WHEREAS, pursuant to Section 2 of the Change of Control Agreement by and between the Company and the Employee dated as of
             (the “Change of Control Agreement”), the Company has agreed to pay the Employee certain amounts and to provide Employee with certain rights and
benefits, subject to the execution of this Release. 
 NOW THEREFORE, in consideration of these premises and the mutual promises contained
herein, and intending to be legally bound hereby, the parties agree as follows: 
 SECTION 1 Consideration. The Employee acknowledges that:
(a) the payments, rights and benefits set forth in Section 2 of the Change of Control Agreement constitute full settlement of all of Employee’s rights under the Change of Control Agreement, (b) the Employee has no entitlement
under any other severance or similar arrangement maintained by the Company, and (c) except as otherwise provided specifically in this Release, the Company does not and will not have any other liability or obligation to the Employee. The
Employee further acknowledges that, in the absence of Employee’s execution of this Release, the payments and benefits specified in Section 2 of the Change of Control Agreement would not otherwise be due to the Employee. 
 SECTION 2 Release and Covenant Not to Sue. The Employee hereby fully and forever releases and discharges the Company and its parents, affiliates and subsidiaries,
including all predecessors and successors, assigns, officers, directors, trustees, Employees, agents and attorneys, past and present, from any and all claims, demands, liens, agreements, contracts, covenants, actions, suits, causes of action,
obligations, controversies, debts, costs, expenses, damages, judgments, orders and liabilities, of whatever kind or nature, direct or indirect, in law, equity or otherwise, whether known or unknown, arising through the date of this Release, out of
Employee’s employment by the Company or the termination thereof, including, but not limited to, any claims for relief or causes of action under the Age Discrimination in Employment Act, 29 U.S.C. § 621 et seq., or any other federal,
state or local statute, ordinance or regulation regarding discrimination in employment and any claims, demands or actions based upon alleged wrongful or retaliatory discharge or breach of contract under any state or federal law. The Employee
expressly represents that he or she has not filed a lawsuit or initiated any other administrative proceeding against the Company (including for purposes of this Section 2, its parents, affiliates and subsidiaries), and that he has not assigned
any claim against the Company (or its parents, affiliates and subsidiaries) to any other person or entity. The Employee further promises not to initiate a lawsuit or to bring any other claim against the Company (or its parents, affiliates and
subsidiaries) arising out of or in any way related to Employee’s employment by the Company or the termination of that employment. The forgoing will not be deemed to release the Company from (a) claims solely to enforce this Release,
(b) claims solely to enforce Section 2 the Change of Control Agreement, (c) claims for indemnification under the Company’s By-Laws, under any indemnification agreement between the Company and the Employee or under any similar
agreement or (d) claims solely to enforce the terms of any equity incentive award agreement between the Employee and the Company. This Release will not prevent the Employee from filing a charge with the Equal Employment Opportunity Commission
(or similar state agency) or participating in any investigation conducted by the Equal Employment Opportunity Commission (or similar state agency); provided, however, that any claims by the Employee for personal relief in connection with such
a charge or investigation (such as reinstatement or monetary damages) would be barred. 
 SECTION 3 Survival. The Employee acknowledges that the terms
of Section 5 of the Change of Control Agreement will survive the termination of Employee’s employment. 

 SECTION 4 Non-Disparagement. The Company (meaning, solely for this purpose, Company’s directors and executive
officers and other individuals authorized to make official communications on Company’s behalf) will not disparage the Employee or the Employee’s performance or otherwise take any action which could reasonably be expected to adversely
affect the Employee’s personal or professional reputation. Similarly, the Employee will not disparage Company or any of its directors, officers, agents or Employees or otherwise take any action which could reasonably be expected to adversely
affect the reputation of the Company or the personal or professional reputation of any of the Company’s directors, officers, agents or Employees. 
 SECTION 5 Cooperation. The Employee further agrees that, subject to reimbursement of Employee’s reasonable expenses, he will cooperate fully with the Company and its counsel with respect to any matter (including litigation,
investigations, or governmental proceedings) which relates to matters with which the Employee was involved during Employee’s employment with Company. The Employee shall render such cooperation in a timely manner on reasonable notice from the
Company. 
 SECTION 6 Rescission Right. The Employee expressly acknowledges and recites that he or she (a) has read and understands this Release
in its entirety, (b) has entered into this Release knowingly and voluntarily, without any duress or coercion; (c) has been advised orally and is hereby advised in writing to consult with an attorney with respect to this Release
before signing it; (d) was provided 21 calendar days after receipt of the Release to consider its terms before signing it (or such longer period as is required for this Release to be effective under the Age Discrimination in Employment
Act or any similar state law); and (e) is provided seven (7) calendar days from the date of signing to terminate and revoke this Release (or such longer period required by applicable state law), in which case this Release shall be
unenforceable, null and void. The Employee may revoke this Release during those seven (7) days (or such longer period required by applicable state law) by providing written notice of revocation to the Company. 
 SECTION 7 Challenge. If the Employee violates or challenges the enforceability of any provisions of the Change of Control Agreement or this Release, no further
payments, rights or benefits under Section 2 of the Change of Control Agreement will be due to the Employee. 
 SECTION 8 Miscellaneous.

 8.1. No Admission of Liability. This Release is not to be construed as an admission of any violation of any federal, state or local
statute, ordinance or regulation or of any duty owed by the Company to the Employee. There have been no such violations, and the Company specifically denies any such violations. 
 8.2. No Reinstatement. The Employee agrees that he will not apply for reinstatement with the Company or seek in any way to be reinstated,
re-employed or hired by the Company in the future. 
 8.3. Successors and Assigns. This Release shall inure to the benefit of and be
binding upon the Company and the Employee and their respective successors, executors, administrators and heirs. The Employee may make any assignment of this Release or any interest herein, by operation of law or otherwise. The Company may assign
this Release to any successor to all or substantially all of its assets and business by means of liquidation, dissolution, merger, consolidation, transfer of assets, or otherwise. 
 8.4. Severability. Whenever possible, each provision of this Release will be interpreted in such manner as to be effective and valid under
applicable law. However, if any provision of this Release is held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability will not affect any other provision, and this Release will be reformed,
construed and enforced as though the invalid, illegal or unenforceable provision had never been herein contained. 
 8.5. Entire
Agreement; Amendments. Except as otherwise provided herein, this Release contains the entire agreement and understanding of the parties hereto relating to the subject matter hereof, and merges and supersedes all prior and contemporaneous
discussions, agreements and understandings of every nature relating to the subject matter hereof. This Release may not be changed or modified, except by an Agreement in writing signed by each of the parties hereto. 

 8.6. Governing Law. This Release shall be governed by, and enforced in accordance with, the laws
of the Commonwealth of Pennsylvania without regard to the application of the principles of conflicts of laws. 
 8.7. Counterparts and
Facsimiles. This Release may be executed, including execution by facsimile signature, in one or more counterparts, each of which shall be deemed an original, and all of which together shall be deemed to be one and the same instrument.

 IN WITNESS WHEREOF, the Company has caused this Release to be executed by its duly authorized officer, and the Employee has executed this
Release, in each case as of the date first above written. 
  

	
	VIROPHARMA, INCORPORATED
	  
  

	 By:
 Title:

	
	Employee

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