Document:

EX-10.24

 Exhibit 10.24 

OFFICE LEASE 

BY AND BETWEEN 

DWF III GATEWAY, LLC, 

a Delaware limited liability company, 

AS LANDLORD 

AND 

BIOTIE THERAPIES, INC., 

a Delaware corporation, 

AS TENANT 

for Premises at Suite 350 
 701
Gateway Boulevard 
 South San Francisco, California 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	ARTICLE 1	 	SALIENT LEASE TERMS	  	1	 
			
	 ARTICLE 2
	 	 ADDITIONAL DEFINITIONS
	  	 	4	  
			
	 ARTICLE 3
	 	 PREMISES AND COMMON AREAS
	  	 	11	  
			
	 3.1
	 	 Demising Clause
	  	 	11	  
	 3.2
	 	 Reservation
	  	 	11	  
	 3.3
	 	 Covenants, Conditions and Restrictions
	  	 	11	  
	 3.4
	 	 Common Areas
	  	 	12	  
			
	 ARTICLE 4
	 	 TERM AND POSSESSION
	  	 	14	  
			
	 4.1
	 	 Commencement Date
	  	 	14	  
	 4.2
	 	 Acknowledgment of Commencement
	  	 	14	  
	 4.3
	 	 Pre-Term Possession
	  	 	15	  
	 4.4
	 	 Delay
	  	 	15	  
	 4.5
	 	 Condition and Acceptance of Work
	  	 	15	  
	 4.6
	 	 Failure to Take Possession
	  	 	15	  
			
	 ARTICLE 5
	 	 MONTHLY BASE RENT
	  	 	16	  
			
	 5.1
	 	 Payment
	  	 	16	  
	 5.2
	 	 Advance Rent
	  	 	16	  
	 5.3
	 	 Late Payment
	  	 	16	  
			
	 ARTICLE 6
	 	 ADDITIONAL RENT
	  	 	17	  
			
	 6.1
	 	 Personal Property, Gross Receipts, Leasing Taxes
	  	 	17	  
	 6.2
	 	 Operating Costs, Taxes
	  	 	17	  
	 6.3
	 	 Method of Payment
	  	 	17	  
			
	 ARTICLE 7
	 	 ACCORD AND SATISFACTION
	  	 	19	  
			
	 7.1
	 	 Acceptance of Payment
	  	 	19	  
			
	 ARTICLE 8
	 	 LETTER OF CREDIT
	  	 	19	  
			
	 8.1
	 	 Letter of Credit
	  	 	19	  
	 8.2
	 	 Transfers
	  	 	20	  
	 8.3
	 	 Restoration
	  	 	20	  
	 8.4
	 	 Renewals
	  	 	21	  
	 8.5
	 	 Draws
	  	 	21	  
	 8.6
	 	 Replacement
	  	 	23	  
	 8.7
	 	 Not a Security Deposit
	  	 	23	  
	 8.8
	 	 Burn Down
	  	 	23	  

  
 i 

							
	ARTICLE 9		USE		23	 
			
	 9.1
		 Permitted Use
		 	23	  
	 9.2
		 Safes, Heavy Equipment
		 	24	  
	 9.3
		 Machinery
		 	24	  
	 9.4
		 Waste or Nuisance
		 	24	  
	 9.5
		 Access
		 	24	  
			
	 ARTICLE 10
		 COMPLIANCE WITH LAWS AND REGULATIONS
		 	24	  
			
	 10.1
		 Compliance Obligations
		 	24	  
	 10.2
		 Condition of Premises
		 	25	  
	 10.3
		 Hazardous Materials
		 	25	  
	 10.4
		 Indemnity
		 	26	  
			
	 ARTICLE 11
		 SERVICE AND EQUIPMENT
		 	27	  
			
	 11.1
		 Climate Control
		 	27	  
	 11.2
		 Elevator Service
		 	28	  
	 11.3
		 Cleaning Public Areas
		 	28	  
	 11.4
		 Refuse Disposal
		 	28	  
	 11.5
		 Janitorial Service
		 	28	  
	 11.6
		 Special Cleaning Service
		 	28	  
	 11.7
		 Electrical
		 	28	  
	 11.8
		 Water
		 	29	  
	 11.9
		 Interruptions
		 	29	  
	 11.10
		 Conservation
		 	30	  
	 11.11
		 Excess Usage
		 	30	  
			
	 ARTICLE 12
		 ALTERATIONS
		 	31	  
			
	 12.1
		 Consent of Landlord; Ownership
		 	31	  
	 12.2
		 Requirements
		 	31	  
	 12.3
		 Liens
		 	32	  
	 12.4
		 Restoration
		 	32	  
			
	 ARTICLE 13
		 PROPERTY INSURANCE
		 	33	  
			
	 13.1
		 Use of Premises
		 	33	  
	 13.2
		 Increase in Premiums
		 	33	  
	 13.3
		 Personal Property Insurance
		 	33	  
	 13.4
		 Landlord’s Insurance
		 	33	  
			
	 ARTICLE 14
		 INDEMNIFICATION, WAIVER OF CLAIMS AND
SUBROGATION
		 	34	  
			
	 14.1
		 Intent and Purpose
		 	34	  
	 14.2
		 Waiver of Subrogation
		 	34	  
	 14.3
		 Form of Policy
		 	34	  

  
 ii 

							
	 14.4
		 Indemnity
		 	34	  
	 14.5
		 Defense of Claims
		 	35	  
	 14.6
		 Waiver of Claims
		 	35	  
	 14.7
		 References
		 	35	  
			
	 ARTICLE 15
		 LIABILITY AND OTHER INSURANCE
		 	35	  
			
	 15.1
		 Tenant’s Insurance
		 	35	  
	 15.2
		 Workers’ Compensation Insurance
		 	36	  
	 15.3
		 Other Insurance
		 	36	  
			
	 ARTICLE 16
		 INSURANCE POLICY REQUIREMENTS AND INSURANCE
DEFAULTS
		 	36	  
			
	 16.1
		 General Requirements
		 	36	  
	 16.2
		 Tenant’s Insurance Defaults
		 	36	  
			
	 ARTICLE 17
		 FORFEITURE OF PROPERTY
		 	37	  
			
	 17.1
		 Removal of Personal Property
		 	37	  
			
	 ARTICLE 18
		 MAINTENANCE AND REPAIRS
		 	37	  
			
	 18.1
		 Landlord’s Obligations
		 	37	  
	 18.2
		 Negligence of Tenant
		 	37	  
	 18.3
		 Tenant’s Obligations
		 	37	  
	 18.4
		 Cleaning
		 	38	  
	 18.5
		 Waiver
		 	38	  
	 18.6
		 Acceptance
		 	38	  
			
	 ARTICLE 19
		 DESTRUCTION
		 	38	  
			
	 19.1
		 Rights of Termination
		 	38	  
	 19.2
		 Repairs
		 	38	  
	 19.3
		 Repair Costs
		 	39	  
	 19.4
		 Waiver
		 	39	  
	 19.5
		 Landlord’s Election
		 	39	  
	 19.6
		 Damage Near End of Term
		 	39	  
			
	 ARTICLE 20
		 CONDEMNATION
		 	40	  
			
	 20.1
		 Definitions
		 	40	  
	 20.2
		 Total Taking
		 	40	  
	 20.3
		 Partial Taking; Common Areas
		 	40	  
	 20.4
		 Termination or Abatement
		 	40	  
	 20.5
		 Restoration
		 	41	  
	 20.6
		 Award
		 	41	  
			
	 ARTICLE 21
		 ASSIGNMENT AND SUBLETTING
		 	41	  

  
 iii 

							
			
	 21.1
		 Lease is Personal
		 	41	  
	 21.2
		 “Transfer of the Premises” Defined
		 	41	  
	 21.3
		 No Transfer Without Consent
		 	42	  
	 21.4
		 When Consent Granted
		 	42	  
	 21.5
		 Permitted Transfer
		 	43	  
	 21.6
		 Procedure for Obtaining Consent
		 	44	  
	 21.7
		 Recapture
		 	45	  
	 21.8
		 Reasonable Restriction
		 	45	  
	 21.9
		 Effect of Transfer
		 	45	  
	 21.10
		 Costs
		 	46	  
	 21.11
		 Restrictions on Marketing the Space
		 	46	  
			
	 ARTICLE 22
		 ENTRY BY LESSOR
		 	46	  
			
	 22.1
		 Rights of Landlord
		 	46	  
			
	 ARTICLE 23
		 SIGNS
		 	47	  
			
	 23.1
		 Lobby and Suite Signage
		 	47	  
	 23.2
		 Approval, Installation and Maintenance
		 	47	  
			
	 ARTICLE 24
		 DEFAULT
		 	47	  
			
	 24.1
		 Definition
		 	47	  
			
	 ARTICLE 25
		 REMEDIES UPON DEFAULT
		 	48	  
			
	 25.1
		 Termination and Damages
		 	48	  
	 25.2
		 Definition
		 	48	  
	 25.3
		 Personal Property
		 	49	  
	 25.4
		 Recovery of Rent; Reletting
		 	49	  
	 25.5
		 No Waiver
		 	50	  
	 25.6
		 Curing Defaults
		 	50	  
	 25.7
		 Cumulative Remedies
		 	50	  
			
	 ARTICLE 26
		 BANKRUPTCY
		 	50	  
			
	 26.1
		 Bankruptcy Events
		 	50	  
			
	 ARTICLE 27
		 SURRENDER OF LEASE
		 	51	  
			
	 27.1
		 No Merger
		 	51	  
			
	 ARTICLE 28
		 LANDLORD’S EXCULPATION
		 	52	  
			
	 28.1
		 Limited Liability
		 	52	  
			
	 ARTICLE 29
		 ATTORNEYS’ FEES
		 	52	  

  
 iv 

							
			
	 29.1
		 Attorneys’ Fees
		 	52	  
			
	 ARTICLE 30
		 NOTICES
		 	52	  
			
	 30.1
		 Writing
		 	52	  
	 30.2
		 Effective Date
		 	53	  
	 30.3
		 Authorization to Receive
		 	53	  
			
	 ARTICLE 31
		 SUBORDINATION AND FINANCING PROVISIONS
		 	53	  
			
	 31.1
		 Priority of Encumbrances
		 	53	  
	 31.2
		 Execution of Documents
		 	53	  
	 31.3
		 Attornment
		 	53	  
	 31.4
		 Notice and Right to Cure Default
		 	54	  
	 31.5
		 Non-Disturbance
		 	54	  
			
	 ARTICLE 32
		 ESTOPPEL CERTIFICATES
		 	54	  
			
	 32.1
		 Execution by Tenant
		 	54	  
	 32.2
		 Financial Statements and Credit Reports
		 	55	  
			
	 ARTICLE 33
		 MISCELLANEOUS PROVISIONS
		 	55	  
			
	 33.1
		 Effect of Waiver
		 	55	  
	 33.2
		 Holding Over
		 	55	  
	 33.3
		 Binding Effect
		 	56	  
	 33.4
		 Time of the Essence
		 	56	  
	 33.5
		 Release of Landlord
		 	56	  
	 33.6
		 Rules and Regulations
		 	56	  
	 33.7
		 Transfer to Purchaser
		 	57	  
	 33.8
		 Late Charges
		 	57	  
	 33.9
		 Interest
		 	57	  
	 33.10
		 Authorization to Execute
		 	57	  
	 33.11
		 Captions
		 	57	  
	 33.12
		 Number and Gender
		 	57	  
	 33.13
		 Modifications
		 	57	  
	 33.14
		 Payments
		 	58	  
	 33.15
		 Severability
		 	58	  
	 33.16
		 No Offer
		 	58	  
	 33.17
		 Light, Air and View
		 	58	  
	 33.18
		 Public Transportation Information
		 	58	  
	 33.19
		 Joint and Several Liability
		 	58	  
	 33.20
		 Survival of Obligations
		 	58	  
	 33.21
		 Real Estate Brokers
		 	58	  
	 33.22
		 Waiver of California Code Sections
		 	59	  
	 33.23
		 Quiet Enjoyment
		 	59	  
	 33.24
		 Representation
		 	59	  
	 33.25
		 Counterparts
		 	59	  

  
 v 

 OFFICE LEASE 

This Office Lease (this “Lease”) is entered and dated for reference purposes only as August 20, 2013 (the “Lease
Reference Date”), by and between “Landlord” and “Tenant” (as such terms are defined below). 
 ARTICLE 1

 SALIENT LEASE TERMS 

In addition to the terms defined throughout this Lease, the following salient terms shall have the following meanings when referred to in this
Lease: 
  

							
	1.1		Rent Payment:		DWF III Gateway, LLC
P.O. Box 7470
San Francisco, CA 94120-7470
			
	1.2		“Landlord” and Notice Address:		 DWF III Gateway, LLC,
c/o Divco West Real Estate Services, Inc.
575 Market Street, 35th floor
San Francisco, CA
94105
Attn: Asset Manager and Property Manager
  
 With a copy to:

 
 Broadway Partners
100 California Street, Suite 1400
San Francisco, CA 94111
Attn:
Asset Manager

			
	1.3		“Tenant” and Notice Address:		 Biotie Therapies, Inc.
  

Prior to Commencement Date:
  

601 Gateway Boulevard, Suite 1200
South San Francisco, California 94080
Attn: VP - Finance

 
 From and after Commencement Date:

 
 At the Premises
Attn: VP -
Finance

  
 1 

							
	1.4		“Premises”:		701 Gateway Boulevard, Suite 350, South San Francisco, California, comprising approximately 15,071 rentable square feet of Rentable Area, as more particularly shown on Exhibit A hereto. The foregoing Rentable Area of the
Premises shall be deemed the actual Rentable Area.
			
	1.5		“Building”:		That building located at 701 Gateway Boulevard, South San Francisco California, containing approximately 170,173 square feet of Rentable Area, which shall be deemed the actual square footage of Rentable Area in the
Building.
			
	1.6		Complex:		The Building and the Common Areas (hereinafter defined), and the land located thereunder.
			
	1.7		“Estimated Commencement Date”:		November 1, 2013
			
	1.8		“Term”:		Sixty (60) months following the Commencement Date, plus any partial month for the month in which the Commencement Date occurs if the Commencement Date occurs on other than the first day of a calendar month. If the
Commencement Date is other than the first day of a calendar month, the first month shall include the remainder of the calendar month in which the Commencement Date occurs plus the first full calendar month thereafter; provided, however, that the
inclusion of any partial month in the first full calendar month shall not entitled Tenant to any additional free rent. Any free rent shall be applied on a daily basis (based on a 30 day month) so that Tenant does not receive additional free rent if
the first month includes a full calendar month plus any partial month.

  
 2 

							
	1.9	 	“Monthly Base Rent”:	 	 Months
	  	
Monthly Base Rent*

		 		 	1 - 12	  	$46,720.10
		 		 	13 - 24	  	$48,121.70
		 		 	25 - 36	  	$49,565.35
		 		 	37 - 48	  	$51,052.31
		 		 	49 - 60	  	$52,583.88
			
		 		 	 *  Subject to possible abatement during the first three (3) full calendar months as provided in Section 5.1
below. The foregoing schedule starts as of the Commencement Date of the Term of the Lease.

			
	1.10	 	“Base Year” for Base Year Costs:	 	 For Base Operating Costs: 2014 calendar year

For Base Taxes: 2014 calendar year

			
	1.11	 	“Letter of Credit”:	 	$250,000.00
			
	1.12	 	“Permitted Use”:	 	The Premises shall be used solely for general office and administrative purposes, but for no other use.
			
	1.13	 	“Proportionate Share”:	 	Tenant’s initial Proportionate Share is 8.86% based on the ratio that the Rentable Area of the Premises (i.e., 15,071 square feet) bears to the Rentable Area of the Building (i.e., 170,173 square
feet).
			
	1.14	 	“Broker(s)”:	 	 Cassidy Turley (“Landlord’s Broker”)

Cresa (“Tenant’s Broker”)

			
	1.15	 	“Guarantor” and Notice Address:	 	[Not applicable]
			
	1.16	 	“Parking Allocation”:	 	Forty-Nine (49) parking passes.
			
	1.17	 	Contents:	 	Included as part of this Lease are the following Exhibits and addenda which are attached hereto and incorporated herein by this reference:
			
		 		 	 Exhibits: A – Floor Plan of the Premises

                B – Work Letter

                C – Acknowledgment of Commencement Date

                D – Rules and Regulations

 
 Addenda: No. 1 – Extension Option

  
 3 

 ARTICLE 2 

ADDITIONAL DEFINITIONS 

The terms defined in this Article 2 shall, for all purposes of this Lease and all agreements supplemental hereto, have the meanings herein
specified, unless expressly stated otherwise. 
 “Base Operating Costs” means the Operating Costs for the calendar year set
forth in Section 1.10 hereof as such Operating Costs shall be increased to be what the Operating Costs would have been if the Building were ninety-five percent (95%) leased and occupied during such calendar year. 

“Base Taxes” means the Taxes for the calendar year set forth in Section 1.10 hereof. 

“Commencement Date” shall mean the earlier of (a) the date by which the Tenant Improvements to be constructed by
Landlord pursuant to Exhibit B, if any, have been “Substantially Completed”, or (b) the date Tenant takes possession of the Premises for the purpose of conducting business therein. However, if there is any delay in
Substantially Completing the Tenant Improvements due to any Tenant Delay, then such delay shall thereupon effect a postponement of the date by which Landlord is obligated to substantially complete the Tenant Improvements; however, the Commencement
Date shall be deemed the date the Tenant Improvements would have been Substantially Completed but for the Tenant Delays. Thus, the date for commencement of the free rent, Rent and all additional rent shall not be delayed by Tenant Delay. 

“Common Areas” shall mean all areas and facilities outside the Premises within the exterior boundaries of the parcel of land
containing the Building of which the Premises form a part, together with the parking and access areas within the Complex, all as provided and designated by Landlord from time to time for the general use and convenience of Tenant and of other tenants
of Landlord having the common use of such areas, and their respective authorized representatives and invitees. As of the date of this Lease, Common Areas include, without limitation, corridors, stairways, elevator shafts, janitor rooms in the
Building, the driveways, parking areas and landscaped areas in the Complex. 
 “Insurance Costs” shall mean all premiums
and costs and expenses for all policies of insurance which may be obtained by Landlord in its discretion for (a) the Premises, Building and the Common Areas of the Complex, or any blanket policies which include the Building or Complex, covering
damage thereto and loss of rents caused by fire and other perils Landlord elects to cover, including, without limitation, coverage for earthquakes and floods, (b) commercial general liability insurance for the benefit of Landlord and its
designees and (c) such other commercially reasonable and customary coverage Landlord elects to obtain for the Premises, Building or Common Areas of the Complex, including, without limitation, coverage for environmental liability and losses.
Notwithstanding anything herein to the contrary, Landlord reserves the right to equitably adjust the Insurance Costs for the Base Year Operating Costs if such Insurance Costs include coverages for perils not required or elected to be carried by
Landlord in the future. Additionally, if any new types of insurance coverage are obtained or effected by Landlord during any calendar year after the Base Year (but is not obtained or 

  
 4 

 
effected during the Base Year) then the cost of such new type of insurance shall be added to cost of the Insurance Costs for the Base Year Operating Costs (but at the rate which would have been
in effect during the Base Year or the rate in effect during such subsequent calendar year, whichever is lower) for the year which such new insurance is initially obtained or effected until such time as Landlord elects to no longer carry such new
type of insurance. 
 “Lease Year” means any fiscal year (as determined by Landlord), or portion thereof, following the
commencement hereof, the whole or any part of which period is included within the Term. 
 “Operating Costs” means the
total amounts paid or payable, whether by Landlord or others on behalf of Landlord, in connection with the ownership, maintenance, repair, replacement and operations of the Building and the Common Areas of the Complex in accordance with
Landlord’s standard operating and accounting procedures. If the Complex consists of multiple buildings, certain Operating Costs may pertain to a particular building(s) and other Operating Costs to the Complex as a whole (such as Operating Costs
for the Common Areas of the Complex). Operating Costs applicable to any particular building within the Complex shall be charged to the building in question whose tenants shall be responsible for payment of their respective proportionate shares in
the pertinent building and other Operating Costs applicable to the Complex (such as the Common Areas of the Complex) shall be charged to each building in the Complex (including the Building) with the tenants in each such building being responsible
for paying their respective proportionate shares in such building of such costs to the extent required under the applicable leases. Landlord shall in good faith attempt to allocate such Operating Costs to the buildings (including the Building) and
such allocation shall be binding on Tenant. Operating Costs shall include, but not be limited to, the aggregate of the amount paid for the following (except as excluded by the express provisions below): 

(1) all fuel used in heating and air conditioning of the Building and Common Areas of the Complex; 

(2) the amount paid or payable for all electricity furnished by Landlord to the Common Areas of the Complex (other than electricity furnished
to and paid for by other tenants by reason of their extraordinary consumption of electricity and that furnished to the other building in the Complex for which the tenants of such other building are responsible for such electrical costs); 

(3) the cost of periodic relamping and reballasting of lighting fixtures; 

(4) the amount paid or payable for all hot and cold water (other than that chargeable to Tenants by reason of their extraordinary consumption
of water and that furnished to other buildings in the Complex for which the tenants of such other building are responsible for such water costs) and sewer costs; 

(5) the amount paid or payable for all labor and/or wages and other payments including cost to Landlord of workers’ compensation and
disability insurance, payroll taxes, welfare and fringe benefits made to janitors, caretakers, and other employees, contractors 

  
 5 

 
and subcontractors of Landlord (including wages of the Building manager) involved in the management, operation, maintenance and repair of the Complex; 

(6) painting for exterior walls of the Building and the Common Areas of the Complex; managerial and administrative expenses; the total
charges of any independent contractors employed in the repair, care, operation, maintenance, and cleaning of the Building and Common Areas of the Complex; 

(7) the amount paid or payable for all supplies occasioned by everyday wear and tear; 

(8) the costs of climate control, window and exterior wall cleaning, telephone and utility costs of the Building and Common Areas of the
Complex; 
 (9) the cost of accounting services necessary to compute the rents and charges payable by Tenants and keep the books of the
Building and Common Areas of the Complex; 
 (10) fees for management, including, without limitation, office rent, supplies, equipment,
salaries, wages, bonuses and other compensation (including fringe benefits, vacation, holidays and other paid absence benefits) relating to employees of Landlord or its agents engaged in the management, operation, repair, or maintenance of the
Building and/or Common Areas of the Complex; 
 (11) fees for legal, accounting (including, without limitation, any outside audit as
Landlord may elect in its sole and absolute discretion), inspection and consulting services; 
 (12) the cost of operating, repairing and
maintaining the Building elevators; 
 (13) the cost of porters, guards, alarm (including any central station signaling systems) and other
protection services; 
 (14) the cost of establishing and maintaining the Building’s directory board; 

(15) payments for general maintenance and repairs to the plant and equipment supplying climate control to the Building and Common Areas of
the Complex; 
 (16) the cost of supplying all services pursuant to Article 11 hereof to the extent such services are not paid by
individual tenants; 
 (17) amortization of the costs, including repair and replacement, of all maintenance and cleaning equipment and
master utility meters and of the costs incurred for repairing or replacing all other fixtures, equipment and facilities serving or comprising the Building and Common Areas of the Complex (including any equipment leasing costs associated therewith if
applicable) which by their nature require periodic or substantial repair or 

  
 6 

 
replacement, and which are not charged fully in the year in which they are incurred, at rates on the various items determined from time to time by Landlord in accordance with sound accounting
principles; 
 (18) community association dues, assessments and charges and property owners’ association dues, assessments and charges
which may be imposed upon Landlord by virtue of any recorded instrument affecting title to the Building, including without limitation, any reciprocal easement agreement and covenants, conditions, easements and restrictions of record, and the cost of
any licenses, permits and inspection fees; 
 (19) all costs to upgrade, improve or change the utility, efficiency or capacity of any
utility or telecommunication system serving the Building and the Common Areas of the Complex; 
 (20) the repair and replacement,
resurfacing and/or repaving of any paved areas, curbs or gutters within the Building or Common Areas of the Complex; 
 (21) the repair and
replacement of any equipment or facilities serving or located within the Complex; 
 (22) the cost of any capital repairs, improvements and
replacements made by the Landlord to the Building or Common Areas of the Complex (“Capital Costs”) which are (a) required to be made in order to conform to changes subsequent to the Commencement Date in any applicable laws,
ordinances, rules, regulations, or orders of any governmental authority having jurisdiction over the Building or Common Areas (“laws”), or are first required to be made after the Commencement Date under any existing laws
(noncompliance with any laws in effect as of the Commencement Date of this Lease which is permitted under applicable law because such improvements were in compliance with applicable laws as of the date they were constructed shall be considered to be
in compliance with applicable law under this Paragraph), (b) incurred for the purpose of reducing other operating expenses or utility costs, or (c) performed to install new or replace capital improvements or building service equipment when
required because of normal wear and tear. The Capital Costs shall be includable in Operating Costs each year only to the extent of that fraction allocable to the year in question calculated by amortizing such Capital Cost over the useful life of the
improvement resulting therefrom, as determined by Landlord in its good faith discretion, with interest on the unamortized balance at the higher of (i) eight percent (8%) per annum; or (ii) the interest rate as may have been paid by
Landlord for the funds borrowed for the purpose of performing the work for which the Capital Costs have been expended, but in no event to exceed the highest rate permissible by law; and 

(23) Insurance Costs. 

Operating Costs shall not include legal, accounting or other professional expenses incurred expressly for negotiating, preparing or enforcing a
lease with a particular tenant, or as a result of a default of a specific tenant. Operating Costs shall further exclude the following: 

(a) interest, principal, points and fees on debts or amortization on any mortgage or mortgages or any other debt instrument encumbering the
Building or the Premises; 

  
 7 

 (b) such of the Operating Costs as are recovered from insurance proceeds or which were required
by the Lease to be covered by insurance or which were paid for directly by Tenant or any third party other than as part of such party’s pro rata share of such costs; 

(c) Costs arising from Landlord’s charitable or political contributions; 

(d) Brokers’ or other leasing commissions and costs incurred in connection with entering into new leases or disputes under existing
leases; 
 (e) costs associated with bad debt losses; 

(f) expenses for any item or service not provided, offered or available to Tenant, but provided exclusively to certain other tenants in the
Building; 
 (g) depreciation and amortization on any mortgage; 

(h) any ground lease or underlying lease payments; 

(i) marketing costs including leasing commissions, attorneys’ fees in connection with the negotiation and preparation of letters, deal
memos, letters of intent, leases, subleases and/or assignments, space planning costs, and other costs and expenses incurred in connection with lease, sublease and/or assignment negotiations and transactions with present or prospective tenants or
other occupants of the Building; 
 (j) costs for acquisition of sculpture, paintings or other objects of art, except to the extent to
replace, when necessary, any sculpture, paintings or other objects of art existing at the Complex as of the date of this Lease so long as such item replaced is of like kind and quality; 

(k) any fines or penalties incurred due to violations by Landlord of any legal requirement which may have been in effect as of the
Commencement Date of this Lease or which arises thereafter (provided, however, that the cost of correcting such violation, as opposed to fines or penalties assessed in excess of such corrective costs and which would not be incurred but for such
violation, shall be included in Operating Costs to the extent that such costs are not otherwise expressly excluded herein); 
 (l) costs for
the removal or abatement of Hazardous Materials to the extent required by applicable law to be removed or abated, excluding such Hazardous Materials for which Tenant is responsible under this Lease; provided, however, that costs incurred in the
removal or abatement of de minimis amounts of Hazardous Materials customarily used in office buildings or used to operate motor vehicles and customarily found in parking facilities shall be included as Operating Costs; 

(m) expenses for tenant improvement work or allowances, inducements, and other concessions for any tenant; and 

  
 8 

 (n) the cost of any repairs, improvements, or replacements made to remedy any structural defect
in the original design or construction of the Building or other buildings in the Complex. 
 Notwithstanding anything to the contrary
contained in this Lease, there shall be no duplication of costs, charges or expenses required to be paid by Tenant pursuant to this Lease, and Landlord shall not seek to recover more than 100% of the actual Operating Costs incurred. 

“Proportionate Share” or “Pro Rata Percent” shall be that fraction (converted to a percentage) the numerator
of which is the Rentable Area (hereinafter defined) of the Premises and the denominator of which is the Rentable Area of the Building. Tenant’s Proportionate Share as of the commencement of the Term hereof is specified in Section 1.13.
Said Proportionate Share may be recalculated by Landlord as may be required effective as at the commencement of any period to which the calculation is applicable in this Lease; provided that Tenant’s Proportionate Share shall not be changed
except in connection with any physical changes in the Premises or Building. Notwithstanding the preceding provisions of this Section, Tenant’s Proportionate Share as to certain expenses may be calculated differently to yield a higher percentage
share for Tenant as to certain expenses in the event Landlord permits other tenants in the Building to directly incur such expenses rather than have Landlord incur the expense in common for the Building (such as, by way of illustration, wherein a
tenant performs its own janitorial services). In such case Tenant’s proportionate share of the applicable expense shall be calculated as having as its denominator the Rentable Area of all floors rentable to tenants in the Building less the
Rentable Area of tenants who have incurred such expense directly. In any case in which Tenant, with Landlord’s consent, incurs such expenses directly, Tenant’s proportionate share will be calculated specially so that expenses of the same
character which are incurred by Landlord for the benefit of other tenants in the Building shall not be prorated to Tenant. Nothing herein shall imply that Landlord will permit Tenant or any other tenant of the Building to incur any Operating Costs.
Any such permission shall be in the sole discretion of the Landlord, which Landlord may grant or withhold in its arbitrary judgment. 

“Real Estate Taxes” or “Taxes” mean all federal, state, county, or local governmental or municipal taxes,
fees, charges or other impositions of every kind and nature, whether general, special, ordinary or extraordinary, (including, without limitation, real estate taxes, general and special assessments, transit taxes, leasehold taxes or taxes based upon
the receipt of rent, including gross receipts or sales taxes applicable to the receipt of rent, unless required to be paid by Tenant, personal property taxes imposed upon the fixtures, machinery, equipment, apparatus, systems and equipment,
appurtenances, furniture and other personal property used in connection with the Complex, or any portion thereof except for any personal property tax paid by Tenant for its personal property), which shall be paid or accrued during any Lease Year
(without regard to any different fiscal year used by such governmental or municipal authority) because of or in connection with the ownership, leasing and operation of the Complex, or any portion thereof. Taxes shall include, without limitation:
(i) Any tax on the rent, right to rent or other income from the Complex, or any portion thereof, or as against the business of leasing the Complex, or any portion thereof; (ii) Any assessment, tax, fee, levy or charge in addition to, or in
substitution, partially or totally, of any assessment, tax, fee, levy or charge previously included within the definition of real property tax, it being acknowledged by Tenant and Landlord that Proposition 13 was adopted by the voters of the State
of California in the June 1978 election (“Proposition 

  
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13”) and that assessments, taxes, fees, levies and charges may be imposed by governmental agencies for such services as fire protection, street, sidewalk and road maintenance, refuse removal
and for other governmental services formerly provided without charge to property owners or occupants, and, in further recognition of the decrease in the level and quality of governmental services and amenities as a result of Proposition 13; and
(iii) Any assessment, tax, fee, levy, or charge allocable to or measured by the area of the leasable premises or the rent payable hereunder, including, without limitation, any business or gross income tax or excise tax with respect to the
receipt of such rent, or upon or with respect to the possession, leasing, operating, management, maintenance, alteration, repair, use or occupancy by a tenant of leased premises, or any portion thereof. Taxes shall also include any governmental or
private assessments or the Complex’s contribution towards a governmental or private cost-sharing agreement for the purpose of augmenting or improving the quality of services and amenities normally provided by governmental agencies. Any
reasonable costs and expenses (including, without limitation, reasonable attorneys’ and consultants’ fees) incurred in attempting to protest, reduce or minimize Taxes shall be included in Taxes in the Lease Year such expenses are incurred.
Notwithstanding anything to the contrary, there shall be excluded from Taxes all excess profits taxes, franchise taxes, gift taxes, capital stock taxes, inheritance and succession taxes, estate taxes, federal and state income taxes, and other taxes
to the extent applicable to Landlord’s general or net income (as opposed to rents, receipts or income attributable to operations at the Building). With respect to any special assessments which may be levied as part of the Taxes and which may be
payable in installments over a period of time, only the amount of the installments due each year shall be included in the Taxes charged to Tenant, whether or not Landlord elects to pay in installments, provided that Landlord has the option of paying
said assessment in installments over a period of time. 
 “Rent” “rent” or “rental” means
Monthly Base Rent and all other sums required to be paid by Tenant pursuant to the terms of this Lease. 
 “Rentable Area”
as used in the Lease shall be determined as follows: 
 (a) Single Tenant Floor. As to each floor of the Building on which the entire
space rentable to tenants is or will be leased to one tenant, Rentable Area shall be the entire area bounded by the inside surface of the exterior glass walls on such floor, including all areas used for elevator lobbies, corridors, special
stairways, special elevators, restrooms, mechanical rooms, electrical rooms and telephone closets, without deduction for columns and other structural portions of the Building or vertical penetrations that are included for the special use of Tenant,
but excluding the area contained within the interior walls of the Building stairs, fire towers, vertical ducts, elevator shafts, flues, vents, stacks, pipe shafts, and the rentable square footage described in Paragraph (c) below. 

(b) Multi-Tenant Floor. As to each floor of the Building on which space is or will be leased to more than one tenant, Rentable Area
attributable to each such lease shall be the total of (i) the entire area included within the Premises covered by such lease, being the area bounded by the inside surface of any exterior glass walls, the exterior of all walls separating such
Premises from any public corridors or other public areas on such floor, and the centerline of all walls separating such Premises from other areas leased or to be leased to other tenants on such floors, (ii) a pro rata portion of the area within
the elevator lobbies, corridors, restrooms, 

  
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mechanical rooms, electrical rooms, telephone closets and their enclosing walls situated on such floor and (iii) the rentable square footage described in Paragraph (c) below. 

(c) Building Load. In any event, Rentable Area shall also include Tenant’s Proportionate Share of the lobbies of the Building and
Tenant’s Proportionate Share of the area of the emergency equipment, fire pump equipment, electrical switching gear, telephone equipment and mail delivery facilities serving the Building. 

(d) Deemed Square Footage. The Rentable Area of the Premises is deemed to be the square footage set forth in Section 1.4 of this
Lease as of the date hereof, and Rentable Area of the Building is deemed to be the square footage set forth in Section 1.5 hereof. Following any physical modifications to the Building, Landlord may from time to time and at Landlord’s
option, re-measure the Rentable Area of the Premises and the Building, which determination shall be conclusive and thereon Tenant’s Proportionate Share shall be adjusted accordingly, but such adjustment shall not affect the Monthly Base Rent.

 “Structural” as herein used shall mean any portion of the Premises, Building or Common Areas of the Complex which
provides bearing support to any other integral member of the Premises, Building or Common Areas of the Complex such as, by limitation, the roof structure (trusses, joists, beams), posts, load bearing walls, foundations, girders, floor joists,
footings, and other load bearing members constructed by Landlord. 
 “Tenant Improvements” shall mean the Tenant
Improvements, if any, as defined in Exhibit B attached hereto to be constructed pursuant to Exhibit B attached hereto. 

ARTICLE 3 
 PREMISES
AND COMMON AREAS 
 3.1 Demising Clause. Landlord hereby leases to Tenant, and Tenant hires from Landlord the Premises,
consisting of the approximate square footage listed in Section 1.4 of the Salient Lease Terms, which the parties agree shall be deemed the actual square footage, subject to adjustment as provided in clause (d) of the definition of Rentable
Area as contained in Article 2. 
 3.2 Reservation. Landlord reserves the area beneath and above the Building as well as the exterior
thereof together with the right to install, maintain, use, repair and replace pipes, ducts, conduits, wires, and structural elements leading through the Premises serving other parts of the Building and Common Areas of the Complex, so long as such
items are concealed by walls, flooring or ceilings. Such reservation in no way affects the maintenance obligations imposed herein. Landlord may change the shape, size, location, number and extent of the improvements to any portion of the Building or
Common Areas of the Complex and/or the address or name of the Building without the consent of Tenant. 
 3.3 Covenants, Conditions and
Restrictions. The parties agree that this Lease is subject to the effect of (a) any covenants, conditions, restrictions, easements, mortgages or deeds of trust, ground leases, rights of way of record, and any other matters or documents of
record; (b) any zoning laws of the city, county and state where the Complex is situated; and (c) general and special taxes not delinquent. Tenant agrees that as to its leasehold estate, Tenant and all

  
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persons in possession or holding under Tenant will conform to and will not violate the terms of any covenants, conditions or restrictions of record which may now or hereafter encumber the
Building or the Complex (hereinafter, the “restrictions”). This Lease is subordinate to the restrictions and any amendments or modifications thereto. 

3.4 Common Areas. Landlord hereby grants to Tenant, for the benefit of Tenant and its employees, suppliers, shippers, customers and
invitees, during the Term of this Lease, the non-exclusive right to use, in common with others entitled to such use, the Common Areas as they exist from time to time, subject to any rights, powers, and privileges reserved by Landlord under the terms
hereof or under the terms of any rules and regulations or restrictions governing the use of the Building or the Complex and subject to the limitation on the number of parking spaces allocated to Tenant. Under no circumstances shall the right herein
granted to use the Common Areas be deemed to include the right to store any property, temporarily or permanently, in the Common Areas. Any such storage shall be permitted only by the prior written consent of Landlord or Landlord’s designated
agent, which consent may be revoked at any time. In the event that any unauthorized storage shall occur then Landlord shall have the right, without notice, in addition to such other rights and remedies that it may have, to remove the property and
charge the cost to Tenant, which cost shall be immediately payable upon demand by Landlord. 
 (a) Common Areas Changes. Landlord
shall have the right, in Landlord’s sole discretion, from time to time to do the following, provided that Landlord shall use commercially reasonable efforts to minimize interference with Tenant’s use: 

(1) To make changes and reductions to the Common Areas, including, without limitation, changes in the location, size, shape and number of
driveways, entrances, parking spaces, parking areas, loading and unloading areas, ingress, egress, direction of traffic, landscaped areas and walkways; 

(2) To close temporarily any of the Common Areas for maintenance purposes so long as reasonable access to the Premises remains available;

 (3) To designate other land outside the boundaries of the Building to be a part of the Common Areas; 

(4) To add additional improvements to the Common Areas; 

(5) To use the Common Areas while engaged in making additional improvements, repairs or alterations to the Building or Complex, or any
portion thereof; 
 (6) To do and perform such other acts and make such other changes in, to or with respect to the Common Areas, Building
and Complex as Landlord may, in the exercise of sound business judgment, deem to be appropriate. 
 (b) Common Area Maintenance.
Landlord shall, in Landlord’s reasonable discretion, maintain the Common Areas in accordance with the standards typically employed by commercial landlords of comparable properties in South San Francisco (subject to reimbursement pursuant to
this Lease), establish and enforce reasonable rules and regulations concerning such areas, close any of the Common Areas to whatever extent required in the 

  
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opinion of Landlord’s counsel to prevent a dedication of any of the Common Areas or the accrual of any rights of any person or of the public to the Common Areas, close temporarily any of the
Common Areas for maintenance purposes, and make changes to the Common Areas including, without limitation, changes in the location of driveways, corridors, entrances, exits, the designation of areas for the exclusive use of others, the direction of
the flow of traffic or construction of additional buildings thereupon. Landlord may provide security for the Common Areas, but is not obligated to do so. Except to the extent caused by the gross negligent or willful misconduct of Landlord, under no
circumstances shall Landlord be liable or responsible for any acts or omissions of any third party providing any services to the Common Areas, Building or other improvements, including, without limitation, any security service, notwithstanding
anything to the contrary contained in this Lease. 
 (c) Parking. Provided Tenant is not in default or breach of any term or
provision beyond any applicable cure period in this Lease and has not vacated the Premises, at no additional charge during the initial Term and any extensions thereof, Tenant is allocated and shall have the non-exclusive and non-preferential right
on an unassigned and unreserved basis to use not more than the number of parking spaces specified in Section 1.16 hereof (the “Parking Spaces”) for use by Tenant and Tenant’s Parties (hereinafter defined), while Tenant’s
Parties are performing work or services for Tenant at the Premises. The location of the Parking Spaces may be designated from time to time by Landlord. At no time, may Tenant or any of Tenant’s Parties use more than the number of Parking Spaces
specified above. 
 (1) General Procedures. The Parking Spaces will not be separately identified; however Landlord reserves the
right in its sole and absolute discretion to separately identify by signs or other markings the area where Tenant’s Parking Spaces will be located. Landlord shall have no obligation to monitor the use of the parking area, nor shall Landlord be
responsible for any loss or damage to any vehicle or other property or for any injury to any person, except to the extent caused by the gross negligent or willful misconduct of Landlord. Said Parking Spaces shall be used only for parking of
automobiles no larger than full size passenger automobiles, sport utility vehicles or small pick-up trucks. Tenant shall comply with all rules and regulations which may be adopted by Landlord from time to time. Tenant shall not at any time use more
parking spaces than the number allocated to Tenant or park vehicles or the vehicles of others in any portion of the Complex designated by Landlord as exclusive parking area for others. Tenant shall be responsible for and breach or violation by
Tenant’s Parties of the parking regulations and requirements in this Lease. Tenant shall not have the exclusive right to use any specific parking space. If Landlord grants to any other tenant the exclusive right to use any particular parking
space(s), Tenant shall not use such spaces. All trucks (other than pick-up trucks) and delivery vehicles shall be (i) temporarily parked for loading and unloading in a location designated by Landlord and otherwise in a manner which does not
interfere with the businesses of other occupants of the Complex, and (ii) permitted to remain on the Complex only so long as is reasonably necessary to complete loading and unloading. In the event Landlord elects in its sole and absolute
discretion or is required by any law to limit or control parking in the Complex, whether by validation of parking tickets or any other method of assessment, Tenant agrees to participate in such validation or assessment program under such reasonable
rules and regulations as are from time to time established by Landlord. Landlord may close off or restrict access to the parking areas from time to time to facilitate construction, alteration, or improvements, without incurring any liability to
Tenant and without any abatement of Rent 

  
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under this Lease. Tenant’s continued right to use the Parking Spaces is conditioned on Tenant’s abiding by all rules and regulations prescribed from time to time for the orderly
operation and use of the parking facility. Tenant shall use all reasonable efforts to ensure that Tenant’s employees and visitors also comply with such rules and regulations. 

(2) Identification. Tenant shall furnish Landlord with a list of its employees’ vehicle license numbers within fifteen
(15) days after taking possession of the Premises and thereafter shall notify Landlord of any changes within five (5) days after request by Landlord. Landlord also reserves the right to implement a system requiring that all employees of
Tenant attach a parking sticker or parking permit to their vehicles. 
 (3) Condition. Tenant’s right to use the number of
allocated Parking Spaces under Section 3.4(c) and all subsections thereof are expressly conditioned upon Tenant being in occupancy of the Premises. 

(4) Remedies. Tenant acknowledges and agrees that a breach of the parking provisions by Tenant or any of Tenant’s Parties may
seriously interfere with Landlord’s operation of the Complex and with the rights or occupancy by other tenants of the Complex. Accordingly, Landlord may suffer damages that are not readily ascertainable. Therefore, if Tenant or any of
Tenant’s Parties use more than the number of allocated Parking Spaces, or park other than as designated by Landlord for the Parking Spaces, or otherwise fail to comply with any of the foregoing provisions, then Landlord, in addition to any
other rights or remedies available at law or in equity or under the Lease, may charge Tenant, as liquidated damages, Twenty-Five Dollars ($25.00) per day for each violation during a calendar year after Tenant has been previously notified on two or
more occasions during such calendar of a violation, or for each violation that is not cured within one day’s notice of such violation, and Tenant shall pay such charge within ten (10) days after request by Landlord. Each vehicle parked in
violation of the foregoing provisions shall be deemed a separate violation. In addition, Landlord may immobilize and/or tow from the Complex any vehicle parked in violation hereof, and/or attach violation stickers or notices to such vehicle. The
cost to remove any such vehicle shall be paid by Tenant within ten (10) days after request by Landlord. Landlord reserves the right in its sole and absolution discretion to have the parking areas operated by a third party and Tenant shall
comply with the rules and regulations of such parking operator. 
 ARTICLE 4 

TERM AND POSSESSION 
 4.1
Commencement Date. The Term of this Lease shall commence on the Commencement Date and shall be for the term specified in Section 1.8 hereof (which includes as set forth in Section 1.8 any partial month at the commencement of the
Term if the Term commences other than on the first day of the calendar month). 
 4.2 Acknowledgment of Commencement. After delivery
of the Premises to Tenant, Tenant shall execute a written acknowledgment of the date of commencement in the form attached hereto as Exhibit C, and by this reference it shall be incorporated herein. The failure or delay by Landlord to
request such acknowledgment or the failure or delay by Tenant in executing and delivery such acknowledgement shall not delay or extend the Commencement Date. 

  
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 4.3 Pre-Term Possession. During the course of construction of the Tenant Improvements,
Landlord shall permit Tenant and its agents, employees and/or contractors, with access to the Premises for the sole purpose of installing Tenant’s data and telecommunications cabling. Additionally, commencing no later than the date which is
fifteen (15) days prior to Substantial Completion of the Tenant Improvements, Landlord shall permit Tenant and its agents, employees and/or contractors, to enter the Premises for the sole purpose of installing Tenant’s furniture, fixtures
and equipment. All such early access and entry shall be subject to all the provisions of this Lease (other than the payment of Monthly Base Rent or utilities) including, without limitation, Tenant’s compliance with the insurance and indemnity
requirements of this Lease. Said early access and entry shall not advance the termination date of this Lease. Tenant agrees that it shall not in any way interfere with the progress of the Tenant Improvements by such entry or access. Should such
entry or access prove an impediment to the progress of the Tenant Improvements, in Landlord’s judgment, Landlord may demand that Tenant forthwith vacate the Premises until such time as Landlord’s work is complete, and Tenant shall
immediately comply with this demand. 
 4.4 Delay. If Landlord, for any reason whatsoever, cannot deliver possession of the Premises
to Tenant with the Tenant Improvements Substantially Completed at the Estimated Commencement Date, this Lease shall not be void or voidable, nor shall Landlord be liable for any loss or damage resulting therefrom, but in that event, there shall be
no accrual of Rent for the period between the Estimated Commencement Date and the Commencement Date, except if the delay is due to a Tenant Delay. Notwithstanding the foregoing, for each day beyond December 31, 2013 (the “Outside
Delivery Date”) that the Commencement Date has not occurred (other than to the extent caused by any Tenant Delay or Force Majeure Delays, as defined in Exhibit B), then in addition to the delay of the Commencement Date, Tenant
shall receive a credit against Monthly Base Rent from and after the Commencement Date equal to one (1) day of Monthly Base Rent for each such day of delay beyond the Outside Delivery Date. 

4.5 Condition and Acceptance of Work. Landlord agrees to deliver possession of the Premises to Tenant in broom clean condition with the
HVAC servicing the Premises, life-safety, mechanical, electrical and plumbing systems serving the Premises in good operating condition. Within thirty (30) days following the date Tenant takes possession of the Premises, Tenant may provide
Landlord with a punch list which sets forth any corrective work to be performed by Landlord with respect to work performed by Landlord; provided, however, that Tenant’s obligation to pay Rent and other sums under this Lease shall not be
affected thereby. If Tenant fails to submit a punch list to Landlord within such thirty (30) day period, Tenant agrees that by taking possession of the Premises it will conclusively be deemed to have inspected the Premises and found the
Premises in satisfactory condition, with all work required of Landlord completed. Tenant acknowledges that neither Landlord, nor any agent, employee or servant of Landlord, has made any representation or warranty, expressed or implied, with respect
to the Premises, Building or Common Areas of the Complex, or with respect to the suitability of them to the conduct of Tenant’s business, nor has Landlord agreed to undertake any modifications, alterations, or improvements of the Premises,
Building or Common Areas of the Complex, except as specifically provided in this Lease. 
 4.6 Failure to Take Possession.
Tenant’s inability or failure to take possession of the Premises when delivery is tendered by Landlord shall not delay the Commencement Date of the 

  
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Lease or Tenant’s obligation to pay Rent. Tenant acknowledges that Landlord shall incur significant expenses upon the execution of this Lease, even if Tenant never takes possession of the
Premises, including, without limitation, brokerage commissions and fees, legal or other professional fees, the costs of space planning and the costs of construction of Tenant Improvements in the Premises. Tenant acknowledges that all of said
expenses, in addition to all other expenses incurred and damages suffered by Landlord, shall be included in measuring Landlord’s damages should Tenant breach the terms of this Lease. 

ARTICLE 5 
 MONTHLY
BASE RENT 
 5.1 Payment. Tenant shall pay to Landlord at the address specified in Section 1.1 or at such other place as
Landlord may otherwise designate, as “Monthly Base Rent” for the Premises the amount specified in Section 1.9 hereof, payable in advance on the first day of each month during the Term of the Lease. If the Term commences on
other than the first day of a calendar month, the rent for the first partial month shall be prorated accordingly. All payments of Monthly Base Rent (including sums defined as rent in Article 2) shall be in lawful money of the United States, and
payable without deduction, offset, counterclaim, prior notice or demand. Notwithstanding anything herein to the contrary, provided that Tenant is not in default beyond any applicable notice and cure period pursuant to the terms of this Lease, then
Tenant shall be excused from the obligation of paying the Monthly Base Rent (but not any other amounts) due hereunder for the first three (3) full calendar months of the Term, in the aggregate amount of One Hundred Forty Thousand One Hundred
Sixty and 30/100 Dollars ($140,160.30) (the “Excused Base Rent”). However, should Tenant default beyond any applicable cure period such that Landlord properly exercises Landlord’s remedies pursuant to Article 25 of this Lease,
then the Pro-Rated Excused Base Rent shall no longer be excused and shall become an obligation of Tenant hereunder, and Landlord shall be entitled to seek recovery of the Pro-Rated Excused Base Rent as part of the damages to which Landlord is
otherwise entitled pursuant to the terms of this Lease. As used herein, the term “Pro-Rated Excused Base Rent” shall mean an amount computed by dividing the Excused Base Rent by sixty (60) (i.e., the number of months in
the initial Term) and then multiplying the resulting quotient by the number of months which would have remained in the initial Term as of the month that Tenant defaults hereunder beyond any applicable notice and cure period. 

5.2 Advance Rent. The rent for the first full month in which Monthly Base Rent is payable shall be paid by Tenant to Landlord upon the
execution of this Lease as advance rent, provided, however, that such amount shall be held by Landlord as additional security deposit pursuant to this Lease until it is applied by Landlord to the first Monthly Base Rent due hereunder. 

5.3 Late Payment. If during any twelve (12) month period, Tenant fails to pay Rent within five (5) days after receipt of
notice that payment is past due on more than three occasions, then Landlord may, by giving written notice to Tenant, require that Tenant pay the Monthly Base Rent and other Rent to Landlord quarterly in advance. 

  
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 ARTICLE 6 

ADDITIONAL RENT 
 6.1
Personal Property, Gross Receipts, Leasing Taxes. This section is intended to deal with impositions or taxes directly attributed to Tenant or this transaction, as distinct from taxes attributable to the Building or Common Areas of the Complex
which are to be allocated among various tenants and others. Tenant shall pay before delinquency any and all taxes, assessments, license fees and public charges levied, assessed or imposed against Tenant or Tenant’s estate in this Lease or the
property of Tenant situated within the Premises which become due during the Term. On demand by Landlord, Tenant shall furnish Landlord with satisfactory evidence of these payments. If such taxes are included in the bill for the Real Estate Taxes for
the Building or Complex, then Tenant shall pay to Landlord as additional rent the amount of such taxes within ten (10) days after demand from Landlord. 

6.2 Operating Costs, Taxes. 

(a) Base Year Increases. If the Operating Costs and Taxes for any Lease Year, calculated on the basis of the greater of (i) actual
Operating Costs and Taxes; or (ii) as if the Building were at least ninety-five percent (95%) occupied and operational for the whole of such Lease Year, are more than the applicable Base Year Costs for Base Operating Costs and Base Taxes
as set forth in section 1.10 (which Base Year Costs shall be calculated separately for each of Operating Costs and Taxes), Tenant shall pay to Landlord its Proportionate Share of any such increase in Operating Costs or Taxes, as the case may be, as
additional Rent as hereinafter provided. 
 (b) Partial Year. If any Lease Year of less than twelve (12) months is included
within the Term, the amount payable by Tenant for such period shall be prorated on a per diem basis (utilizing a thirty (30) day month, three hundred sixty (360) day year). 

6.3 Method of Payment. Any additional Rent payable by Tenant under Sections 6.1 and 6.2 hereof shall be paid as follows, unless
otherwise provided: 
 (a) Estimated Monthly. During the Term, Tenant shall pay to Landlord monthly in advance with its payment of Monthly
Base Rent, one-twelfth (l/12th) of the amount of such additional Rent as estimated by Landlord in advance, in good faith, to be due from Tenant. If at any time during the course of the fiscal year, Landlord determines that Operating Costs and/or
Taxes are projected to vary from the then estimated costs for such items by more than ten percent (10%), Landlord may, by written notice to Tenant, revise the estimated Operating Costs and/or Taxes for the balance of such fiscal year, and
Tenant’s monthly installments for the remainder of such year shall be adjusted so that by the end of such fiscal year Tenant will have paid to Landlord Tenant’s Proportionate Share of the such revised expenses for such year. 

(b) Annual Reconciliation. Annually, as soon as is reasonably possible after the expiration of each Lease Year, Landlord shall prepare
in good faith and deliver to Tenant a comparative statement setting forth (1) the Operating Costs, Taxes and Insurance Costs for such 

  
 17 

 
Lease Year, and (2) the amount of additional Rent as determined in accordance with the provisions of this Article 6. 

(c) Adjustment. If the aggregate amount of such estimated additional Rent payments made by Tenant in any Lease Year should be less than
the additional Rent due for such year, then Tenant shall pay to Landlord as additional Rent upon demand the amount of such deficiency. If the aggregate amount of such additional Rent payments made by Tenant in any Lease Year of the Term should be
greater than the additional Rent due for such year, then should Tenant not be otherwise in default hereunder, the amount of such excess will be applied by Landlord to the next succeeding installments of such additional Rent due hereunder; and if the
Term has expired and there is any such excess for the last year of the Term, the amount thereof will be refunded by Landlord to Tenant within thirty (30) days of the last day of the Term, provided Tenant is not otherwise in default under the
terms of this Lease. 
 (d) Inspection. Tenant shall have the right at its own expense to inspect the books and records of Landlord
pertaining to Operating Costs, Insurance Costs and Taxes once in any calendar year by any employee of Tenant or by a certified public accountant mutually acceptable to Landlord and Tenant (provided such certified public accountant charges for its
service on an hourly basis and not based on a percentage of any recovery or similar incentive method) (“Tenant’s Auditor”) at reasonable times, and upon reasonable written notice to Landlord as hereinafter provided.
Tenant’s right to inspect such books and records is conditioned upon Tenant first paying Landlord the full amount billed by Landlord. Within ninety (90) days after receipt of Landlord’s annual reconciliation of Operating Costs,
Insurance Costs and Taxes, Tenant shall have the right, after at least thirty (30) days’ prior written notice to Landlord, to inspect at the offices of Landlord or its property manager, the books and records of Landlord pertaining solely
to the Operating Costs, Insurance Costs and Taxes for the immediately preceding calendar year covered in such annual reconciliation statement, and, during the first three (3) years of the initial Term only, the Base Year. All expenses of the
inspection shall be borne by Tenant and must be completed within fifteen (15) days after commencement of such inspection (provided that such fifteen day period shall be extended on a day for day basis for each day Landlord does not in good
faith cooperate in Tenant’s inspection). If Tenant’s inspection reveals a discrepancy in the comparative annual reconciliation statement, Tenant shall deliver a copy of the inspection report and supporting calculations to Landlord within
thirty (30) days after completion of the inspection. If Tenant and Landlord are unable to resolve the discrepancy within thirty (30) days after Landlord’s receipt of the inspection report, either party may upon written notice to the
other have the matter decided by an inspection by an independent certified public accounting firm approved by Tenant and Landlord (the “CPA Firm”), which approval shall not be unreasonably withheld or delayed. If the inspection by
the CPA Firm shows that the actual aggregate amount of Operating Costs, Insurance Costs or Taxes payable by Tenant is greater than the amount previously paid by Tenant for such accounting period, Tenant shall pay Landlord the difference within
thirty (30) days. If the inspection by the CPA Firm shows that the actual applicable amount is less than the amount paid by Tenant, then the difference shall be applied in payment of the next estimated monthly installments of Operating Costs,
Insurance Costs and/or Taxes owing by Tenant, or in the event such accounting occurs following the expiration of the Term hereof, such difference shall be promptly refunded to Tenant. Tenant shall pay for the cost of the inspection by the CPA Firm,
unless such inspection shows that Landlord overstated the aggregate amount Operating Costs, Insurance Costs or Taxes 

  
 18 

 
by more than five percent (5%), in which case Landlord shall pay for the cost of the inspection by the CPA Firm and Tenant’s Auditor, not to exceed the amount of any such overstatement by
Landlord. 
 Tenant acknowledges and agrees that any information revealed in the above described inspection may contain proprietary and
sensitive information and that significant damage could result to Landlord if such information were disclosed to any party other than Tenant’s auditors. Tenant shall not in any manner disclose, provide or make available any information revealed
by the inspection to any person or entity without Landlord’s prior written consent, which consent may be withheld by Landlord in its sole and absolute discretion, except to the extent required by applicable law or contract. 

ARTICLE 7 
 ACCORD
AND SATISFACTION 
 7.1 Acceptance of Payment. No payment by Tenant or receipt by Landlord of a lesser amount of Monthly Base
Rent or any other sum due hereunder, shall be deemed to be other than on account of the earliest due rent or payment, nor shall any endorsement or statement on any check or any letter accompanying any such check or payment be deemed an accord and
satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such rent or payment or pursue any other remedy available in this Lease, at law or in equity. Landlord may accept any
partial payment from Tenant without invalidation of any contractual notice required to be given herein (to the extent such contractual notice is required) and without invalidation of any notice required to be given pursuant to California Code of
Civil Procedure Section 1161, et seq., or of any successor statute thereto. 
 ARTICLE 8 

LETTER OF CREDIT 
 8.1
Letter of Credit. Concurrent with its execution of this Lease, Tenant shall deliver to Landlord, as protection for the full and faithful performance by Tenant of all of its obligations under this Lease and for all losses and damages Landlord
may suffer (or that Landlord reasonably estimates it may suffer) as a result of any breach, default or failure to perform by Tenant under this Lease, an irrevocable and unconditional negotiable standby Letter of Credit (“Letter of
Credit”), in the form as is acceptable to Landlord, payable at an office in the San Francisco Bay Area, California, running in favor of Landlord and issued by a solvent, nationally recognized bank with a long term rating of BBB or higher,
under the supervision of the Superintendent of Banks of the State of California, or a national banking association (an “Acceptable Issuing Bank”), in the amount provided in Section 1.11 of this Lease (the “Letter of
Credit Amount”). Tenant shall pay all expenses, points, or fees incurred by Tenant in obtaining the Letter of Credit and any replacement Letter of Credit. The bank issuing the Letter of Credit (the “Bank”) shall be subject
to Landlord’s prior written approval, which approval shall not be withheld by Landlord if the proposed Bank is an Acceptable Issuing Bank. If an Acceptable Issuing Bank is declared insolvent or taken over by the Federal Deposit Insurance
Corporation or any governmental agency for any reason or does not meet the standards to be approved an Acceptable Issuing Bank, Tenant shall deliver a replacement Letter of Credit from another Bank approved by Landlord that meets the standards for
an Acceptable Issuing Bank 

  
 19 

 
within the earlier of (i) thirty (30) days after notice from Landlord that the Bank does not meet the standard for an Acceptable Issuing Bank, or (ii) the date the Bank is declared
insolvent or taken over for any reason by the Federal Deposit Insurance Corporation or any other governmental agency. In addition, the Letter of Credit shall expressly provide for the following: 

(a) shall be “callable” at sight, irrevocable, and unconditional; 

(b) shall be maintained in effect, whether through renewal or extension, for the period from the date of this Lease and continuing until the
date (the “Letter of Credit Expiration Date”) that is ninety (90) days after the expiration of the Term (as the Term may be extended). The Letter of Credit may be for one year period, provided the Letter of Credit is
automatically extended for not less than a one year period unless the issuing Bank provides written notice to Landlord not less than sixty (60) days prior to the then expiration date of the Letter of Credit that the issuing Bank will not renew
or extend the Letter of Credit, in which case Tenant shall deliver to Landlord a replacement Letter of Credit not less than thirty (30) days prior to the scheduled expiration date of the then existing Letter of Credit held by Landlord without
any action whatsoever on the part of Landlord; 
 (c) shall be fully assignable by Landlord, its successors, and assignees of its interest
in the Premises; 
 (d) shall permit partial draws and multiple presentations and drawings; and 

(e) shall be otherwise subject to the Uniform Customs and Practices for Documentary Credits, International Chamber of Commerce Publication
No. 600 (UCP600), or the International Standby Practices-ISP 98, International Chamber of Commerce Publication No. 590 (1998). 

8.2 Transfers. The Letter of Credit shall also provide that Landlord, its successors, and assigns, may, at any time and without notice
to Tenant and without first obtaining Tenant’s consent, transfer (one or more times) all or any portion of its interest in and to the Letter of Credit to another party, person, or entity, provided such transferee is the assignee of the
Landlord’s rights and interests in and to this Lease and expressly assumes the same and Landlord’s obligations under the Lease, or to any lender providing financing to Landlord. In the event of a transfer of Landlord’s interest in the
Building, Landlord shall transfer the Letter of Credit, in whole or in part, to the transferee and Landlord shall then (provided such transferee assumes all of Landlord’s obligations under this Lease), be released by Tenant from all liability
therefor, and it is agreed that the provisions of this Section shall apply to every transfer or assignment of the whole or any portion of the Letter of Credit to a new landlord. In connection with any such transfer of the Letter of Credit by
Landlord, Tenant shall execute and submit to the Bank such applications, documents, and instruments as may be necessary to effectuate such transfer, and Tenant shall be responsible for paying the Bank’s transfer and processing fees in
connection with any such transfer. 
 8.3 Restoration. If, as a result of any drawing by Landlord on the Letter of Credit, the amount
of the Letter of Credit shall be less than the Letter of Credit Amount, Tenant shall, within ten (10) business days after the drawdown by Landlord and notice thereof to Tenant, take 

  
 20 

 
such actions as are required to restore the Letter of Credit Amount, which may include providing a replacement Letter of Credit for the full Letter of Credit Amount, provided such additional
Letter(s) of Credit or replacement Letter of Credit comply with the applicable requirements of this Article 8 and all subsections thereof of this Lease. If Tenant fails to comply with this requirement, such failure shall be deemed a rent default
under Section 24.1(a) of this Lease, provided that if Landlord is prevented from delivering a notice of default to Tenant or otherwise declaring a default by Tenant for any reason, including, without limitation, because Tenant has filed a
voluntary petition, or an involuntary petition has been filed against Tenant, under the Bankruptcy Code, then no such notice or declaration of default and cure period shall be required for a rent default under Section 24.1(a) of this Lease.

 8.4 Renewals. Tenant covenants and warrants that it will neither assign nor encumber the Letter of Credit or any part of it and
that neither Landlord nor its successors or assigns will be bound by any such assignment, encumbrance, attempted assignment, or attempted encumbrance. Without limiting the generality of the foregoing, if the Letter of Credit expires earlier than the
Letter of Credit Expiration Date, Landlord will accept a renewal of the letter of credit (such renewal letter of credit to be in effect and delivered to Landlord, as applicable, not later than forty-five (45) days before the expiration of the
Letter of Credit), which shall be irrevocable and automatically renewable as required above through the Letter of Credit Expiration Date on the same terms as the expiring Letter of Credit or such other terms as may be acceptable to Landlord in its
sole discretion. However, if the Letter of Credit is not timely renewed, or if Tenant fails to maintain the Letter of Credit in the amount and in accordance with the terms set forth herein, then Landlord shall have the right to present the Letter of
Credit to the Bank to draw on the Letter of Credit, and the proceeds of the Letter of Credit may be applied by Landlord against any Rent payable by Tenant under this Lease that is not paid when due and to pay for all losses and damages that Landlord
has suffered or that Landlord reasonably estimates that it will suffer as a result of any breach or default by Tenant under this Lease. Any unused proceeds shall be deemed held by Landlord as security in accordance with applicable laws, but need not
be segregated from Landlord’s other assets. Landlord agrees to pay to Tenant within sixty (60) days after the expiration of the Term of this Lease the amount of any proceeds of the Letter of Credit received by Landlord and not applied
against any Rent payable by Tenant under this Lease, or not used to pay for any losses and damages suffered by Landlord (or reasonably estimated by Landlord that it will suffer) as a result of any breach or default by Tenant under this Lease;
provided, however, that if before the Letter of Credit Expiration Date a voluntary petition is filed by Tenant, or an involuntary petition is filed against Tenant by any of Tenant’s creditors, under the Bankruptcy Code, then Landlord shall not
be obligated to make such payment in the amount of the unused Letter of Credit proceeds until either all preference issues relating to payments under this Lease have been resolved in such bankruptcy or reorganization case or such bankruptcy or
reorganization case has been dismissed. 
 8.5 Draws. Tenant acknowledges and agrees that Landlord is entering into this Lease in
material reliance on the ability of Landlord to draw on the Letter of Credit on the occurrence of any breach, default or failure to perform on the part of Tenant under this Lease. If Tenant shall breach or fail to perform any provision of this Lease
or otherwise be in default under this Lease, Landlord may, but without obligation to do so, and without notice to Tenant, draw on the Letter of Credit, in part or in whole, to cure any breach or default of Tenant and to compensate Landlord for any
and all damages of any kind or nature sustained or which Landlord reasonably 

  
 21 

 
estimates that it will sustain resulting from Tenant’s breach or default and to which Landlord is entitled under this Lease, including any damages that accrue upon termination of the Lease
under the Lease and/or Section 1951.2 of the California Civil Code or any similar provision. The use, application, or retention of any proceeds of the Letter of Credit, or any portion of it, by Landlord shall not prevent Landlord from
exercising any other right or remedy provided by this Lease or by any applicable law, it being intended that Landlord shall not first be required to proceed against the Letter of Credit, and shall not operate as a limitation on any recovery to which
Landlord may otherwise be entitled. Tenant agrees not to interfere in any way with payment to Landlord of the proceeds of the Letter of Credit, following a draw properly made by Landlord of any portion of the Letter of Credit. No condition or term
of this Lease shall be deemed to render the Letter of Credit conditional to justify the issuer of the Letter of Credit in failing to honor a drawing on such Letter of Credit in a timely manner. Tenant agrees and acknowledges that (1) the Letter
of Credit constitutes a separate and independent contract between Landlord and the Bank; (2) Tenant is not a third party beneficiary of such contract; (3) Tenant has no property interest whatsoever in the Letter of Credit; and (4) if
Tenant becomes a debtor under any chapter of the Bankruptcy Code, neither Tenant, any trustee, nor Tenant’s bankruptcy estate shall have any right to restrict or limit Landlord’s claim or rights to the Letter of Credit by application of
Section 502(b)(6) of the U.S. Bankruptcy Code or otherwise. 
 In addition, Landlord, or its then managing agent, shall have the right
to draw down an amount up to the face amount of the Letter of Credit if any of the following shall have occurred or be applicable: 
 (a)
Landlord states that such amount is due to Landlord under the terms and conditions of this Lease, provided that if Landlord is prevented from delivering a notice of default to Tenant for any reason, including, without limitation, because Tenant has
filed a voluntary petition, or an involuntary petition has been filed against Tenant, under the Bankruptcy Code (hereinafter defined), then no such notice and cure period shall be required; 

(b) Tenant has filed a voluntary petition under any chapter of the U.S. Bankruptcy Code or any similar state law (collectively, the
“Bankruptcy Code”); 
 (c) Tenant has assigned any or all of its assets to creditors in accordance with any federal or
state laws; 
 (d) an involuntary petition has been filed against Tenant or any guarantor of Tenant’s obligations under this Lease
under any chapter of the Bankruptcy Code, which petition is not dismissed within sixty (60) days after the date it is filed; provided, however, that if Tenant is still operating its business in the Premises and this Lease has not been
terminated, Landlord may draw upon the Letter of Credit only to the extent such amount is due Landlord under the terms of this Lease or the guaranty of this Lease; 

(e) the Bank has notified Landlord that the Letter of Credit will not be renewed or extended through the Letter of Credit Expiration Date; or

 (f) the Bank does not meet the standard for an Acceptable Issuing Bank and Tenant has not delivered a replacement Letter of Credit form
an Acceptable Issuing Bank within 

  
 22 

 
the earlier of (i) thirty (30) days after notice from Landlord that the Bank does not meet the standard for an Acceptable Issuing Bank, or (ii) the date the Bank is declared
insolvent or taken over for any reason by the Federal Deposit Insurance Corporation or any other governmental agency. 
 8.6
Replacement. Tenant may, from time to time, replace any existing Letter of Credit with a new Letter of Credit if the new Letter of Credit: 

(a) Becomes effective at least 30 days before expiration of the Letter of Credit that it replaces; 

(b) Is in the applicable Letter of Credit Amount; 

(c) Is issued by an Acceptable Issuing Bank or a Bank otherwise acceptable to Landlord in its sole discretion; and 

(d) Otherwise complies with the requirements of this Article 8 and all subsections thereof. 

8.7 Not a Security Deposit. Landlord and Tenant acknowledge and agree that in no event or circumstance shall the Letter of Credit or
any renewal of it or any proceeds applied by Landlord as provided in this Lease be (1) deemed to be or treated as a “security deposit” within the meaning of California Civil Code Section 1950.7, (2) subject to the terms of
Section 1950.7, or (3) intended to serve as a “security deposit” within the meaning of Section 1950.7. Landlord and Tenant (1) agree that Section 1950.7 and any and all other laws, rules, and regulations applicable
to security deposits in the commercial context (“Security Deposit Laws”) shall have no applicability or relevancy to the Letter of Credit, and (2) waive any and all rights, duties, and obligations either party may now or in the
future have relating to or arising from the Security Deposit Laws. 
 8.8 Burn Down. Subject to the remaining terms of this
Section 8.8, and provided that during the twelve (12) month period immediately preceding the effective date of any reduction of the Letter of Credit, Tenant has not been in default under any provision of this Lease and failed to cure such
default within any applicable notice and cure period, then Tenant shall have the right to reduce the amount of the Letter of Credit so that the Letter of Credit Amount will be $157,751.64 effective as of the first day of the third (3rd) lease
year. In order to effect any such reduction, Tenant shall either deliver an amendment to the existing Letter of Credit or a replacement letter of credit in the new amount that otherwise complies with all other applicable requirements specified in
this Section 8. Notwithstanding anything in this Section 8 to the contrary, there shall be no return of the Letter of Credit to Tenant at any time while Tenant is in default of any of its obligations under this Lease. 

ARTICLE 9 
 USE

 9.1 Permitted Use. The Premises may be used and occupied only for the purposes specified in Section 1.12 hereof, and for
no other purpose or purposes. Tenant shall not use, or permit to be used, the Premises in any manner that will violate applicable laws, disturb any other 

  
 23 

 
tenant in the Building or Complex, or obstruct or interfere with the rights of other tenant or occupants of the Building or Complex, or injure or annoy them or create any unreasonable smells,
noise or vibrations (taking into account the nature and tenant-mix of the Building). Tenant shall not do, permit or suffer in, on, or about the Premises the sale of any alcoholic liquor without the written consent of Landlord first obtained. Tenant
shall not allow the Premises to be used for any improper, immoral, unlawful or objectionable purpose. 
 9.2 Safes, Heavy Equipment.
Tenant shall not place a load upon any floor of the Premises which exceeds the lesser of fifty (50) pounds per square foot live load or such other amount specified in writing by Landlord from time to time. Landlord reserves the right to
prescribe the weight and position of all safes and heavy installations which Tenant wishes to place in the Premises so as properly to distribute the weight thereof, or to require plans prepared by a qualified structural engineer at Tenant’s
sole cost and expense for such heavy objects. Notwithstanding the foregoing, Landlord shall have no liability for any damage caused by the installation of such heavy equipment or safes. 

9.3 Machinery. Business machines and mechanical equipment belonging to Tenant which cause noise and/or vibration that may be
transmitted to the structure of the Building or to any other leased space to such a degree as to be objectionable to Landlord or to any tenants in the Complex shall be placed and maintained by the party possessing the machines or equipment, at such
party’s expense, in settings of cork, rubber or spring type noise and/or vibration eliminators, and Tenant shall take such other measures as needed to eliminate vibration and/or noise. If the noise or vibrations cannot be eliminated, Tenant
must remove such equipment within ten (10) days following written notice from Landlord. 
 9.4 Waste or Nuisance. Tenant shall
not commit, or suffer to be committed, any waste upon the Premises, or any nuisance, or other act or thing which may disturb the quiet enjoyment of any other tenant or occupant of the Complex in which the Premises are located. 

9.5 Access. Tenant shall have access to the Premises twenty-four hours a day, seven days a week, subject to any security requirements
and regulations that may be in effect at the time. Tenant acknowledges and agrees that it shall use the card-key system currently in place for entry into the Building and into the Premises. 

ARTICLE 10 

COMPLIANCE WITH LAWS AND REGULATIONS 

10.1 Compliance Obligations. 

(a) Tenant shall, at its sole cost and expense, comply with all of the requirements of all municipal, state and federal authorities now in
force, or which may hereafter be in force, pertaining to Tenant’s particular use of the Premises or to any Alterations made by or on behalf of Tenant (exclusive of the Tenant Improvements), and shall faithfully observe in the use or occupancy
of the Premises all municipal ordinances and state and federal statutes, laws and regulations now or hereafter in force, including, without limitation, the “Environmental Laws” (as hereinafter defined), and the Americans with Disabilities
Act, 42 U.S.C. §§ 12101-12213 (and any rules, regulations, restrictions, guidelines, requirements or publications 

  
 24 

 
promulgated or published pursuant thereto), whether or not any of the foregoing were foreseeable or unforeseeable at the time of the execution of this Lease. The judgment of any court of
competent jurisdiction, or the admission of Tenant in any action or proceeding against Tenant, whether Landlord be a party thereto or not, that any such requirement, ordinance, statute or regulation pertaining to the Premises has been violated,
shall be conclusive of that fact as between Landlord and Tenant. As of the Lease Reference Date, the Premises have not undergone an inspection by a Certified Access Specialist (CASp). 

(b) Landlord shall, as an Operating Cost (to the extent permitted under Article 6) comply with all of the applicable requirements of all
municipal, state and federal authorities now in force, or which may hereafter be in force, pertaining to the Common Areas of the Building and any component of the Building for which Landlord has maintenance and repair obligations under this Lease,
and shall faithfully observe municipal ordinances and state and federal statutes, laws and regulations now or hereafter in force, including, without limitation, the Environmental Laws requiring remediation and the ADA regarding accessibility,
whether or not any of the foregoing were foreseeable or unforeseeable at the time of the execution of this Lease, but only to the extent required by any governmental authority with jurisdiction thereof; provided, if any work is required to comply
with any such law as a result of Tenant’s use of the Premises or the operation of Tenant’s business, or any Alteration made by or on behalf of Tenant, then such work shall be performed by Landlord at the sole cost and expense of Tenant.

 10.2 Condition of Premises. Subject to Landlord’s work, if any, as referred to in Exhibit B to this Lease, and
to Landlord’s obligations expressly set forth in this Lease, Tenant hereby accepts the Premises in the condition existing as of the date of occupancy, subject to all applicable zoning, municipal, county and state laws, ordinances, rules,
regulations, orders, restrictions of record, and requirements in effect during the Term or any part of the Term hereof regulating the Premises, and without representation, warranty or covenant by Landlord, express or implied, as to the condition,
habitability or safety of the Premises, the suitability or fitness thereof for their intended purposes, or any other matter. 
 10.3
Hazardous Materials. 
 (a) Hazardous Materials. As used herein, the term “Hazardous Materials” shall mean any
wastes, materials or substances (whether in the form of liquids, solids or gases, and whether or not air-borne), which are or are deemed to be (i) pollutants or contaminants, or which are or are deemed to be hazardous, toxic, ignitable,
reactive, corrosive, dangerous, harmful or injurious, or which present a risk to public health or to the environment, or which are or may become regulated by or under the authority of any applicable local, state or federal laws, judgments,
ordinances, orders, rules, regulations, codes or other governmental restrictions, guidelines or requirements, any amendments or successor(s) thereto, replacements thereof or publications promulgated pursuant thereto, including, without limitation,
any such items or substances which are or may become regulated by any of the Environmental Laws (as hereinafter defined); (ii) listed as a chemical known to the State of California to cause cancer or reproductive toxicity pursuant to
Section 25249.8 of the California Health and Safety Code, Division 20, Chapter 6.6 (Safe Drinking Water and Toxic Enforcement Act of 1986); or (iii) a pesticide, petroleum, including crude oil or any fraction thereof, asbestos or an
asbestos-containing material, a polychlorinated biphenyl, radioactive material, or urea formaldehyde. 

  
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 (b) Environmental Laws. In addition to the laws referred to in Section 10.3(a) above,
the term “Environmental Laws” shall be deemed to include, without limitation, 33 U.S.C. Section 1251 et seq., 42 U.S.C. Section 6901 et seq., 42 U.S.C. Section 7401 et seq., 42 U.S.C.
Section 9601 et seq., and California Health and Safety Code Section 25100 et seq., and 25300 et seq., California Water Code Section 13020 et seq., or any successor(s) thereto, all local, state and federal
laws, judgments, ordinances, orders, rules, regulations, codes and other governmental restrictions, guidelines and requirements, any amendments and successors thereto, replacements thereof and publications promulgated pursuant thereto, which deal
with or otherwise in any manner relate to, air or water quality, air emissions, soil or ground conditions or other environmental matters of any kind. 

(c) Use of Hazardous Materials. Tenant agrees that during the Term of this Lease, there shall be no use, presence, disposal, storage,
generation, leakage, treatment, manufacture, import, handling, processing, release, or threatened release of Hazardous Materials on, from or under the Premises (individually and collectively, “Hazardous Use”) except to the extent
that, and in accordance with such conditions as, Landlord may have previously approved in writing in its sole and absolute discretion. However, without the necessity of obtaining such prior written consent, Tenant shall be entitled to use and store
only those Hazardous Materials which are (i) typically used in the ordinary course of business in an office for use in the manner for which they were designed and in such limited amounts as may be normal, customary and necessary for
Tenant’s business in the Premises, and (ii) in full compliance with Environmental Laws, and all judicial and administrative decisions pertaining thereto. For the purposes of this Section 10.3(c), the term Hazardous Use shall include
Hazardous Use(s) on, from or under the Premises by Tenant or any of its directors, officers, employees, shareholders, partners, invitees, agents, contractors or occupants (collectively, “Tenant’s Parties”), whether known or
unknown to Tenant, and whether occurring and/or existing during or prior to the commencement of the Term of this Lease. 
 (d)
Compliance. Tenant agrees that during the Term of this Lease Tenant shall not be in violation of any federal, state or local law, ordinance or regulation relating to industrial hygiene, soil, water, or environmental conditions on, under or
about the Premises including, but not limited to, the Environmental Laws. 
 (e) Inspection and Testing by Landlord. Landlord shall
have the right at all times during the term of this Lease to (i) inspect the Premises and to (ii) conduct tests and investigations to determine whether Tenant is in compliance with the provisions of this Section. Except in case of
emergency, Landlord shall give reasonable notice to Tenant before conducting any inspections, tests, or investigations. The cost of all such inspections, tests and investigations shall be borne by Tenant if Tenant is in breach of Section 10.3
of this Lease. Neither any action nor inaction on the part of Landlord pursuant to this Section 10.3(e) shall be deemed in any way to release Tenant from, or in any way modify or alter, Tenant’s responsibilities, obligations, and/or
liabilities incurred pursuant to Section 10.3 hereof. 
 10.4 Indemnity. Tenant shall indemnify, hold harmless, and, at
Landlord’s option (with such attorneys as Landlord may approve in advance and in writing), defend Landlord and Landlord’s officers, directors, shareholders, partners, members, managers, employees, contractors, property managers, agents and
mortgagees and other lien holders, from and against 

  
 26 

 
any and all “Losses” (hereinafter defined) arising from or related to: (a) any violation or alleged violation by Tenant or any of Tenant’s Parties of any of the requirements,
ordinances, statutes, regulations or other laws referred to in this Article 10, including, without limitation, the Environmental Laws; (b) any breach of the provisions of this Article 10 by Tenant or any of Tenant’s Parties; or
(c) any Hazardous Use on, about or from the Premises of any Hazardous Material approved by Landlord under this Lease. The term “Losses” shall mean all claims, demands, expenses, actions, judgments, damages (whether
consequential, direct or indirect, known or unknown, foreseen or unforeseen), penalties, fines, liabilities, losses of every kind and nature (including, without limitation, property damage, diminution in value of Landlord’s interest in the
Premises or the Complex, damages for the loss or restriction on use of any space or amenity within the Building or the Complex, damages arising from any adverse impact on marketing space in the Complex, sums paid in settlement of claims and any
costs and expenses associated with injury, illness or death to or of any person), suits, administrative proceedings, costs and fees, including, but not limited to, attorneys’ and consultants’ fees and expenses, and the costs of cleanup,
remediation, removal and restoration, that are in any way related to any matter covered by the foregoing indemnity. 
 ARTICLE 11

 SERVICE AND EQUIPMENT 

11.1 Climate Control. So long as Tenant is not in default under any of the covenants of this Lease beyond any applicable notice and
cure period, Landlord shall provide climate control to the Premises from 8:00 a.m. to 6:00 p.m. (the “Climate Control Hours”) on weekdays (Saturdays, Sundays and holidays excepted) to maintain a temperature adequate for comfortable
occupancy, provided that Landlord shall have no responsibility or liability for failure to supply climate control service when making repairs, alterations or improvements or when prevented from so doing by strikes or any cause beyond Landlord’s
reasonable control. Any climate control furnished for periods not within the Climate Control Hours pursuant to Tenant’s request shall be at Tenant’s sole cost and expense in accordance with rate schedules promulgated by Landlord from time
to time. Upon request, Landlord shall advise Tenant of the then current rate schedule. Tenant acknowledges that Landlord has installed in the Building a system for the purpose of climate control. Any use of the Premises not in accordance with the
design standards or any arrangement of partitioning which interferes with the normal operation of such system may require changes or alterations in the system or ducts through which the climate control system operates. Any changes or alterations so
occasioned, if such changes can be accommodated by Landlord’s equipment, shall be made by Tenant at its cost and expense but only with the written consent of Landlord first had and obtained, and in accordance with drawings and specifications
and by a contractor first approved in writing by Landlord. If installation of partitions, equipment or fixtures by Tenant necessitates the re-balancing of the climate control equipment in the Premises, the same will be performed by Landlord at
Tenant’s expense. Tenant acknowledges that up to one (1) year may be required after Tenant has fully occupied the Premises in order to adjust and balance the climate control systems. Any charges to be paid by Tenant hereunder shall be due
within ten (10) days of receipt of an invoice from Landlord, which invoice may precede Landlord’s expenditure for the benefit of Tenant. 

  
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 11.2 Elevator Service. Landlord shall provide elevator service (which may be with or
without operator at Landlord’s option) provided that Tenant, its employees, and all other persons using such services shall do so at their own risk. 

11.3 Cleaning Public Areas. Landlord shall maintain and keep clean the street level lobbies, sidewalks, truck dock, public corridors,
elevator lobbies, restrooms not a part of individual premises and other public portions of the Building. 
 11.4 Refuse Disposal.
Tenant shall pay Landlord, within ten (10) days of being billed therefor, for the removal from the Premises and the Building of such refuse and rubbish of Tenant as shall exceed that ordinarily accumulated daily in the routine of a reasonable
office. 
 11.5 Janitorial Service. Landlord shall provide cleaning and janitorial service in and about the Complex and Premises five
days a week (which is currently scheduled for Monday through Friday, holidays excepted, subject to change by Landlord) in accordance with commercially reasonable standards in an office building in the city in which the Building is located. 

11.6 Special Cleaning Service. To the extent that Tenant shall require special or more frequent cleaning and/or janitorial service
(hereinafter referred to as “Special Cleaning Service”) Landlord may, upon reasonable advance notice from Tenant, elect to furnish such Special Cleaning Service and Tenant agrees to pay Landlord, within ten (10) days of being
billed therefor, Landlord’s charge for providing such additional service. Special Cleaning Service shall include but shall not be limited to the following to the extent such services are beyond those typically provided pursuant to
Section 11.5 above: 
 (a) The cleaning and maintenance of Tenant eating facilities other than the normal and ordinary cleaning and
removal of garbage, which special cleaning service shall include, without limitation, the removal of dishes, utensils and excess garbage; it being acknowledged that normal and ordinary cleaning service does not involve placing dishes, glasses and
utensils in the dishwasher, cleaning any coffee pot or other cooking mechanism or cleaning the refrigerator or any appliances; 
 (b) The
cleaning and maintenance of Tenant computer centers, including peripheral areas other than the normal and ordinary cleaning and removal of garbage if Tenant so desires; 

(c) The cleaning and maintenance of special equipment areas, locker rooms, and medical centers; 

(d) The cleaning and maintenance in areas of special security; and 

(e) The provision of consumable supplies for private toilet rooms. 

11.7 Electrical. During the Term of this Lease, there shall be available to the Premises electrical facilities comparable to those
supplied in other comparable office buildings in the vicinity of the Building to provide sufficient power for normal lighting and office machines of similar low electrical consumption, and one personal computer for each desk station, but not for the
server room HVAC system to be installed by Landlord as part of the Tenant Improvements 

  
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(the “Server Room HVAC”) or any additional computers or extraordinary data processing equipment, special lighting or any other item of electrical equipment which requires a
voltage other than one hundred ten (110) volts single phase, as determined by Landlord in its sole and absolute discretion; and provided, however, that if the installation of such electrical equipment requires additional air conditioning
capacity above that normally provided to tenants of the Building or above standard usage of existing capacity as determined by Landlord in its sole and absolute discretion, then the additional air conditioning installation and/or operating costs
attributable thereto shall be paid by Tenant. Tenant agrees not to use any apparatus or device in, upon or about the Premises which may materially increase the amount of such electricity usually furnished or supplied to the Premises, and Tenant
further agrees not to connect any apparatus or device to the wires, conduits or pipes or other means by which such electricity is supplied, for the purpose of using additional or unusual amounts of electricity, without the prior written consent of
Landlord. At all times, Tenant’s use of electric current shall never exceed Tenant’s share of the capacity of the feeders to the Building or the risers or wiring installation. Tenant shall not install or use or permit the installation or
use in the Premises of any computer or electronic data processing or ancillary equipment or any other electrical apparatus designed to operate on electrical current in excess of 110 volts and 5 amps per machine, without the prior written consent of
Landlord, which may be exercised in Landlord’s sole and absolute discretion. If Tenant shall require electrical current in excess of that usually furnished or supplied for use of the Premises as general office space, Tenant shall first procure
the written consent of Landlord (which may be exercised in Landlord’s sole and absolute discretion) to the use thereof and Landlord or Tenant may (i) cause a meter to be installed in or for the Premises, or (ii) if Tenant elects not
to install said meter, Landlord may reasonably estimate such excess electrical current. The cost of any meters (including, without limitation, the cost of any installation) or surveys to estimate such excess electrical current shall be paid by
Tenant. Landlord’s approval of any space plan, floor plan, construction plans, specifications, or other drawings or materials regarding the construction of the Tenant Improvements or any alterations shall not be deemed or construed as consent
by Landlord under this paragraph to Tenant’s use of such excess electrical current as provided above. Tenant agrees to pay to Landlord, promptly upon demand therefor, all costs of such electrical current consumed as well as an additional use
charge calculated by said meters (at the rates charged for such services to the Building by the municipality or the local public utility) or the amount specified in said estimate, as the case may be, plus any additional expense incurred in keeping
account of the electrical current so consumed, which additional expense Landlord shall advise Tenant within a reasonable time after request by Tenant. 

11.8 Water. During the Term of this Lease, if water is made available to the Premises, then water shall be used for drinking, lavatory
and office kitchen purposes only as applicable. If Tenant requires, uses or consumes water for any purpose in addition to ordinary drinking, lavatory, and office kitchen purposes (as determined by Landlord in its sole and absolute discretion), as
applicable, Landlord may reasonably estimate such excess and Tenant shall pay for same. At Tenant’s sole cost and expense, Landlord may also install a water meter and thereby measure Tenant’s water consumption for all purposes, and Tenant
shall keep said meter and installation equipment in good working order and repair at Tenant’s own cost and expense. Tenant agrees to pay for water consumed, as shown in said meter, as and when bill are rendered. 

11.9 Interruptions. It is understood that Landlord does not warrant that any of the services referred to above or any other services
which Landlord may supply will be free from 

  
 29 

 
interruption. Tenant acknowledges that any one or more such services may be suspended or reduced by reason of repairs, alterations or improvements necessary to be made, by strikes or accidents,
by any cause beyond the reasonable control of Landlord, or by orders or regulations of any federal, state, county or municipal authority. Any such interruption or suspension of services shall not be deemed an eviction (constructive or otherwise) or
disturbance of Tenant’s use and possession of the Premises or any part thereof, nor render Landlord liable to Tenant for damages by abatement of Rent or otherwise, nor relieve Tenant of performance of Tenant’s obligations under this Lease.
Notwithstanding anything herein to the contrary, if the Premises, or a material portion of the Premises, is made untenantable, inaccessible or unsuitable for the ordinary conduct of Tenant’s business, as a result of an interruption in any of
the services required to be provided by Landlord pursuant to this Article 11, then (i) Landlord shall use commercially reasonable good faith efforts to restore the same as soon as is reasonably possible, (ii) if, despite such commercially
reasonable good faith efforts by Landlord, such interruption persists for a period in excess of three (3) consecutive business days, then Tenant, as its sole remedy, shall be entitled to receive an abatement of Monthly Base Rent payable
hereunder during the period beginning on the fourth (4th) consecutive business day of such interruption and ending on the day the utility or service has been restored; provided, however, that in the event such interruption is not due to
Landlord’s negligence or willful misconduct, then such abatement shall only apply to the extent Landlord collects proceeds under the policy of rental-loss insurance the cost of which has been included in Operating Expenses and the proceeds from
which are allocable to the Premises. 
 11.10 Conservation. Tenant agrees to comply with the conservation, use and recycling policies
and practices from time to time established by Landlord for the use of utilities and services supplied by Landlord, and the utility charges payable by Tenant hereunder may include such excess usage penalties or surcharges as may from time to time be
established by Landlord for the Building. Landlord may reduce the utilities supplied to the Premises and the Common Areas as required or permitted by any mandatory or voluntary water, energy or other conservation statute, regulation, order or
allocation or other program. 
 11.11 Excess Usage. In addition to Tenant’s Proportionate Share of Operating Costs, Tenant shall
pay for (the “Excess Utility Costs”) (i) all utility costs (including, without limitation, electricity, water and/or natural gas) attributable to any HVAC or other cooling system located in the Premises or that provides service
to Tenant’s server room, data center or other areas with special equipment or for special use (including, without limitation the Server Room HVAC, and (ii) all such utility costs consumed outside of the normal office hours of 7:00 a.m. to
6:00 p.m. Monday through Friday excluding holidays, and (iii) all utility costs consumed at the Premises in excess of normal office use (such as by way of example only, extended hours of operation, heavier use of duplicating, computer,
telecommunications or other equipment in excess of the normal use for general office uses, or a density of workers in excess of the normal density for general office uses). Tenant shall pay for such Excess Utility Costs within thirty (30) days
after receipt of a billing from Landlord. Such billing shall be determined in good faith by Landlord based on separate meters, submeters or other measuring devices (such as an eamon demon device) to measure consumption of such utilities at the
Premises or otherwise based on a commercially reasonable allocation given Tenant’s use of the Premises; provided, however, Landlord shall install a separate metering device to measure the utility consumption of the Server Room HVAC as part of
the Tenant Improvements. The charge for such excess use (other than 

  
 30 

 
with respect to the Server Room HVAC, which shall be maintained by Tenant in accordance with Section 18.3 below) may include a commercially reasonable charge for increased wear and tear on
existing equipment caused by Tenant’s excess consumption. Tenant shall pay, as additional rent, for the Excess Utility Costs within thirty (30) days after receipt of a billing from Landlord, and if requested by Landlord, Tenant shall pay
for Excess Utility Costs, as additional rent, on an estimated basis in advance on the first day of each month, subject to an annual reconciliation of such Excess Utility Costs. 

ARTICLE 12 

ALTERATIONS 
 12.1
Consent of Landlord; Ownership. Tenant shall not make, or suffer to be made, any alterations, additions or improvements, including, without limitation, any alterations, additions or improvements that result in increased telecommunication
demands or require the addition of new communication or computer wires, cables and related devises or expand the number of telephone or communication lines dedicated to the Premises by the Building’s telecommunication design (individually, an
“alteration” and collectively, “alterations”) to the Premises, or any part thereof, without the written consent of Landlord first had and obtained. Subject to Section 12.4 below, any alterations, except trade
fixtures, shall upon expiration or termination of this Lease become a part of the realty and belong to Landlord. Except as otherwise provided in this Lease, Tenant shall have the right to remove its trade fixtures placed upon the Premises provided
that Tenant restores the Premises as indicated below. 
 12.2 Requirements. Any alteration performed by Tenant shall be subject to
strict conformity with the following requirements: 
 (a) All alterations shall be at the sole cost and expense of Tenant; 

(b) Prior to commencement of any work of alteration, Tenant shall submit detailed plans and specifications, including working drawings
(hereinafter referred to as “Plans”), of the proposed alteration, which shall be subject to the consent of Landlord in accordance with the terms of Section 12.1 above; 

(c) Following approval of the Plans by Landlord, Tenant shall give Landlord at least ten (10) days’ prior written notice of any
commencement of work in the Premises so that Landlord may post notices of non-responsibility in or upon the Premises as provided by law; 

(d) No alteration shall be commenced without Tenant having previously obtained all appropriate permits and approvals required by and of
governmental agencies; 
 (e) All alterations shall be performed in a skillful and workmanlike manner, consistent with the best practices
and standards of the construction industry, and pursued with diligence in accordance with said Plans previously approved by Landlord and in full accord with all applicable laws and ordinances. All material, equipment, and articles incorporated in
the alterations are to be new and of recent manufacture and of the most suitable grade for the purpose intended; 

  
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 (f) Tenant must obtain the prior written approval from Landlord for Tenant’s contractors
before the commencement of any work. Tenant’s contractor for any work shall maintain all of the insurance reasonably required by Landlord, including, without limitation, commercial general liability and workers’ compensation; 

(g) As a condition of approval of an alteration the estimated cost of which exceeds $50,000, Landlord may require performance and labor and
materialmen’s payment bonds issued by a surety approved by Landlord, in a sum equal to the cost of the alterations guarantying the completion of the alteration free and clear of all liens and other charges in accordance with the Plans. Such
bonds shall name Landlord as beneficiary; 
 (h) The alteration must be performed in a manner such that they will not unreasonably interfere
with the quiet enjoyment of the other tenants in the Complex. 
 12.3 Liens. Tenant shall keep the Premises and the Complex in which
the Premises are situated free from any liens arising out of any work performed, materials furnished or obligations incurred by Tenant. In the event a mechanic’s or other lien is filed against the Premises, Building or the Complex as a result
of a claim arising through Tenant, and not removed within five (5) days of notice to Tenant, Landlord may demand that Tenant furnish to Landlord a surety bond satisfactory to Landlord in an amount equal to at least one hundred fifty percent
(150%) of the amount of the contested lien claim or demand, indemnifying Landlord against liability for the same and holding the Premises free from the effect of such lien or claim. Such bond must be posted within ten (10) days following
notice from Landlord. In addition, Landlord may require Tenant to pay Landlord’s reasonable attorneys’ fees and costs in participating in any action to foreclose such lien if Landlord shall decide it is to its best interest to do so. If
Tenant fails to post such bond within said time period, Landlord, after five (5) days’ prior written notice to Tenant, may pay the claim prior to the enforcement thereof, in which event Tenant shall reimburse Landlord in full, including
attorneys’ fees, for any such expense, as additional rent, with the next due rental. 
 12.4 Restoration. Tenant shall return
the Premises to Landlord at the expiration or earlier termination of this Lease in good and sanitary order, condition and repair, free of rubble and debris, broom clean, reasonable wear and tear excepted. If Landlord desires the Premises, or any
part thereof, restored to its condition prior to the making of any alterations, installations and improvements (whether or not permitted hereunder), Landlord shall so notify Tenant in writing, concurrently with granting its consent to installation,
in which case Tenant, prior to the end of the Term, shall restore said Premises or the designated portions thereof as the case may be, to its original condition, entirely at its own expense, excepting normal wear and tear. No removal of the Tenant
Improvements that are contemplated by the Information (as defined in Section 4.1 of the Work Letter) shall be required. All damage to the Premises caused by the removal of such trade fixtures and other personal property that Tenant is permitted
to remove under the terms of this Lease and/or such restoration shall be repaired by Tenant at its sole cost and expense prior to termination. 

  
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 ARTICLE 13 

PROPERTY INSURANCE 
 13.1
Use of Premises. No use shall be made or permitted to be made on the Premises, nor acts done, which will increase the existing rate of insurance upon the building in which the Premises are located or upon any other Building in the Complex or
cause the cancellation of any insurance policy covering the Building, or any part thereof, nor shall Tenant sell, or permit to be kept, used or sold, in or about the Premises, any article which may be prohibited by the standard form of “All
Risk” fire insurance policies. Tenant shall, at its sole cost and expense, comply with any and all requirements pertaining to the Premises, of any insurance organization or company, necessary for the maintenance of reasonable property damage
and commercial general liability insurance, covering the Premises, the Building, or the Complex. 
 13.2 Increase in Premiums. Tenant
agrees to pay Landlord, as additional Rent, within ten (10) days after receipt by Tenant of Landlord’s billing therefor, any increase in premiums for insurance policies which may be carried by Landlord on the Premises, Building or Complex
resulting from any negligent or intentional act or omission of Tenant or any of its contractors, partners, officers, employees or agents. 

13.3 Personal Property Insurance. Tenant shall maintain in full force and effect on alterations, additions, improvements, carpeting,
floor coverings, panelings, decorations, fixtures, inventory and other business personal property situated in or about the Premises a policy or policies providing protection against any peril included within the classification “All Risk”
to the extent of one hundred percent (100%) of their replacement cost, or that percentage of the replacement cost required to negate the effect of a co-insurance provision, whichever is greater. No such policy shall have a deductible in a
greater amount than Five Thousand Dollars ($5,000.00). Tenant shall also insure in the same manner the physical value of all its leasehold improvements and alterations in the Premises. During the term of this Lease, the proceeds from any such policy
or policies of insurance shall be used for the repair or replacement of the fixtures, equipment, and leasehold improvements so insured. Landlord shall have no interest in said insurance (except as a loss payee with respect to any alterations or
other leasehold improvements made to the Premises), and will sign all documents necessary or proper in connection with the settlement of any claim or loss by Tenant. Tenant shall also maintain business interruption insurance and insurance for all
plate glass upon the Premises. All insurance specified in this Section 13.3 to be maintained by Tenant shall be maintained by Tenant at its sole cost. 

13.4 Landlord’s Insurance. In addition to any other insurance Landlord elects to maintain, Landlord shall maintain special form
property insurance covering all improvements on the Complex owned by Landlord, including the Building, the Premises and Common Areas, in an amount of not less than one hundred percent (100%) of the full insurable replacement cost (excluding the
land, foundations, footings and other elements that are not customarily covered by “full replacement cost” insurance), with coverage for perils as set forth under the Causes of Loss-Special Form which may include if elected to be obtained
by Landlord coverage extended for perils of flood and earthquake in such amounts determined by Landlord. Any insurance carried by Landlord pursuant to this Lease may be brought within the coverage of a so-called blanket policy or policies of
insurance carried and maintained by Landlord. 

  
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 ARTICLE 14 

INDEMNIFICATION, WAIVER OF CLAIMS AND SUBROGATION 

14.1 Intent and Purpose. This Article 14 is written and agreed to in respect of the intent of the parties to assign the risk of loss,
whether resulting from negligence of the parties or otherwise, to the party who is obligated hereunder to cover the risk of such loss with insurance. Thus, the indemnity and waiver of claims provisions of this Lease have as their object, so long as
such object is not in violation of public policy, the assignment of risk for a particular casualty to the party carrying the insurance for such risk, without respect to the causation thereof. 

14.2 Waiver of Subrogation. So long as their respective insurers so permit, Tenant and Landlord hereby mutually waive their respective
rights of recovery against each other for any loss insured by fire, extended coverage, All Risks or other insurance now or hereafter existing for the benefit of the respective party but only to the extent of the net insurance proceeds payable under
such policies. Each party shall obtain any special endorsements required by their insurer to evidence compliance with the aforementioned waiver. 

14.3 Form of Policy. Tenant’s policies of insurance required hereunder shall (a) be provided at Tenant’s expense;
(b) name the Landlord Entities as additional insureds (General Liability) and loss payee (Property—Special Form); (c) be issued by an insurance company with a minimum Best’s rating of “A:VII” during the Term; and
(d) provide that said insurance shall not be canceled unless thirty (30) days’ prior written notice (ten days for non-payment of premium) shall have been given to Landlord; a certificate of Liability insurance on ACORD Form 25 and a
certificate of Property insurance on ACORD Form 27 shall be delivered to Landlord by Tenant upon the Commencement Date and at least thirty (30) days prior to each renewal of said insurance. 

14.4 Indemnity. Tenant shall protect, indemnify and hold Landlord, Landlord’s investment manager, and the trustees, boards of
directors, officers, general partners, beneficiaries, stockholders, employees and agents of each of them (the “Landlord Entities”) harmless from and against any and all loss, claims, liability or costs (including court costs and
attorney’s fees) incurred by reason of (a) any damage to any property (including but not limited to property of any Landlord Entity) or any injury (including but not limited to death) to any person occurring in, on or about the Premises,
Building and or Complex to the extent that such injury or damage shall be caused by or arise from any actual or alleged act, neglect, fault, or omission by or of Tenant or any of Tenant’s agents, contractors, employees, licensees or invitees
(collectively, the “Tenant Entities”) to meet any standards imposed by any duty with respect to the injury or damage; (b) the conduct or management of any work or thing whatsoever done by the Tenant in or about the Premises or
from transactions of the Tenant concerning the Premises; (c) Tenant’s failure to comply with any and all governmental laws, ordinances and regulations applicable to the condition or use of the Premises or its occupancy; or (d) any
breach or default on the part of Tenant in the performance of any covenant or agreement on the part of the Tenant to be performed pursuant to this Lease. The provisions of this Article shall survive the termination of this Lease with respect to any
claims or liability accruing prior to such termination. 

  
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 14.5 Defense of Claims. In the event any action, suit or proceeding is brought against
Landlord by reason of any such occurrence, Tenant, upon Landlord’s request, will at Tenant’s expense resist and defend such action, suit or proceeding, or cause the same to be resisted and defended by counsel designated either by Tenant or
by the insurer whose policy covers the occurrence and in either case approved by Landlord. The obligations of Tenant under this Section arising by reason of any occurrence taking place during the Lease term shall survive any termination of this
Lease but shall not apply to the extent any action, suit or proceeding is brought against Landlord by reason of a claim of gross negligence or willful misconduct of Landlord, its agents, officers and employees. 

14.6 Waiver of Claims. Tenant, as a material part of the consideration to be rendered to Landlord, hereby waives all claims against
Landlord for damages to goods, wares, merchandise and loss of business in, upon or about the Premises and injury to Tenant, its agents, employees, invitees or third persons, in, upon or about the Premises, Building or Complex from any cause arising
at any time, including breach of the provisions of this Lease, the failure to provide security or Landlord’s negligence in connection therewith, or the negligence of the parties hereto, except to the extent such damages or injury are caused by
the gross negligence or willful actions of Landlord, its agents, officers and employees. 
 14.7 References. Wherever in this Article
the term Landlord or Tenant is used and such party is to receive the benefit of a provision contained in this Article, such term shall refer not only to that party but also to its shareholders, officers, directors, employees, partners, members,
managers, mortgagees and agents. 
 ARTICLE 15 

LIABILITY AND OTHER INSURANCE 

15.1 Tenant’s Insurance. Tenant shall, at Tenant’s expense, obtain and keep in force during the term of this Lease, a
commercial general liability insurance policy insuring Tenant and protecting Landlord and the Landlord Entities against any liability to the public or to any invitee of Tenant or a Landlord Entity against the risks of, bodily injury and property
damage, personal injury, contractual liability, completed operations, products liability, host liquor liability, owned and non-owned automobile liability arising out of the ownership, use, occupancy or maintenance of the Premises and all areas
appurtenant thereto. Such insurance shall be a combined single limit policy in an amount not less than One Million Dollars ($1,000,000.00) per occurrence with a Two Million Dollar ($2,000,000.00) annual aggregate. Landlord, the Landlord Entities and
any lender and any other party in interest designated by Landlord shall be named as additional insured(s). The policy shall contain cross liability endorsements with coverage for Landlord for the negligence of Tenant even though Landlord is named as
an additional insured; shall insure performance by Tenant of the indemnity provisions of this Lease; shall be primary, not contributing with, and not in excess of coverage which Landlord may carry; shall provide for severability of interest; shall
provide that an act or omission of one of the insured or additional insureds which would void or otherwise reduce coverage shall not void or reduce coverages as to the other insured or additional insureds; and shall afford coverage after the term of
this Lease (by separate policy or extension if necessary) for all claims based on acts, omissions, injury or damage which occurred or arose (or the onset of which occurred or arose) in whole or in part during the term of this Lease. The limits of
said insurance shall not limit any 

  
 35 

 
liability of Tenant hereunder. Not more frequently than every year, if, in the reasonable opinion of Landlord, the amount of liability insurance required hereunder is not adequate, Tenant shall
promptly increase said insurance coverage as required by Landlord. 
 15.2 Workers’ Compensation Insurance. Tenant shall carry
Workers’ Compensation insurance as required by law, including an employers’ liability endorsement. 
 15.3 Other Insurance.
Tenant shall keep in force throughout the Term: (a) Business Auto Liability covering owned, non-owned and hired vehicles with a limit of not less than $1,000,000 per accident; (b) Employers Liability with limits of $1,000,000 each
accident, $1,000,000 disease policy limit, $1,000,000 disease – each employee; and (c) Excess Liability in the amount of $5,000,000. In addition, whenever Tenant shall undertake any alterations, additions or improvements in, to or about
the Premises (“Work”) the aforesaid insurance protection must extend to and include injuries to persons and damage to property arising in connection with such Work, without limitation including liability under any applicable
structural work act, and such other insurance as Landlord shall require; and the policies of or certificates evidencing such insurance must be delivered to Landlord prior to the commencement of any such Work. 

ARTICLE 16 

INSURANCE POLICY REQUIREMENTS AND INSURANCE DEFAULTS 

16.1 General Requirements. All insurance policies required to be carried by Tenant (except Tenant’s business personal property
insurance) hereunder shall conform to the following requirements: 
 (a) The insurer in each case shall carry a designation in
“Best’s Insurance Reports” as issued from time to time throughout the term as follows: Policyholders’ rating of A; financial rating of not less than VII; 

(b) The insurer shall be qualified to do business in the state in which the Premises are located; 

(c) The policy shall be in a form and include such endorsements as are acceptable to Landlord; 

(d) Certificates of insurance shall be delivered to Landlord at commencement of the term and certificates of renewal at least thirty
(30) days prior to the expiration of each policy; 
 (e) Each policy shall require that Landlord be notified in writing by the insurer
at least thirty (30) days prior to any cancellation or expiration of such policy, or any reduction in the amounts of insurance carried. 

16.2 Tenant’s Insurance Defaults. If Tenant fails to obtain any insurance required of it under the terms of this Lease and such
failure is not cured within three (3) business days notice, Landlord may, at its option, but is not obligated to, obtain such insurance on behalf of Tenant and bill Tenant, as additional rent, for the cost thereof. Payment shall be due within
ten (10) days of receipt of the billing therefor by Tenant. 

  
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 ARTICLE 17 

FORFEITURE OF PROPERTY 

17.1 Removal of Personal Property. Tenant agrees that as at the date of termination of this Lease or repossession of the Premises by
Landlord, by way of default or otherwise, it shall remove all personal property to which it has the right to ownership pursuant to the terms of this Lease. Any and all such property of Tenant not removed by such date shall, at the option of
Landlord, irrevocably become the sole property of Landlord. Tenant waives all rights to notice and all common law and statutory claims and causes of action which it may have against Landlord subsequent to such date as regards the storage,
destruction, damage, loss of use and ownership of the personal property affected by the terms of this Article. Tenant acknowledges Landlord’s need to relet the Premises upon termination of this Lease or repossession of the Premises and
understands that the forfeitures and waivers provided herein are necessary to aid said reletting, and to prevent Landlord incurring a loss for inability to deliver the Premises to a prospective Tenant. 

ARTICLE 18 

MAINTENANCE AND REPAIRS 

18.1 Landlord’s Obligations. Subject to the other provisions of this Lease imposing obligations in this respect upon Tenant,
Landlord shall repair, replace and maintain the external and Structural parts of the Building and Common Areas of the Complex which do not comprise a part of the Premises and are not leased to others, janitor and equipment closets and shafts within
the Premises designated by Landlord for use by it in connection with the operation and maintenance of the Complex, and all Common Areas. Landlord shall perform such repairs, replacements and maintenance with reasonable dispatch, in a good and
workmanlike manner; but Landlord shall not be liable for any damages, direct, indirect or consequential, or for damages for personal discomfort, illness or inconvenience of Tenant by reason of failure of such equipment, facilities or systems or
reasonable delays in the performance of such repairs, replacements and maintenance, unless caused by the gross negligence or deliberate act or omission of Landlord. The cost for such repairs, maintenance and replacement shall be included in
Operating Costs. 
 18.2 Negligence of Tenant. If the Building, the elevators, boilers, engines, pipes or apparatus used for the
purpose of climate control of the Building or operating the elevators, or if the water pipes, drainage pipes, electric lighting or other equipment of the Building, or the roof or the outside walls of the Building, fall into a state of disrepair or
become damaged or destroyed through the negligence or intentional act of Tenant, its agents, officers, partners, employees or servants, the cost of the necessary repairs, replacements or alterations shall be borne by Tenant who shall pay the same to
Landlord as additional charges forthwith on demand. 
 18.3 Tenant’s Obligations. Tenant shall repair the Premises, including
without limiting the generality of the foregoing, all interior partitions and walls, fixtures, Tenant Improvements and alterations in the Premises, fixtures and shelving, and special mechanical and electrical equipment which equipment is not a
normal part of the Premises installed by or for Tenant, 

  
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reasonable wear and tear, damage with respect to which Landlord has an obligation to repair as provided in Section 18.1 and Article 19 hereof only excepted. Without limiting the generality
of the foregoing, Tenant shall obtain and keep in force a preventive maintenance contract on the Server Room HVAC providing for regular (at least quarterly) inspection and maintenance by a qualified service contractor(s) reasonably acceptable to
Landlord. Prior to April 1 of each calendar year, Tenant shall deliver Landlord written confirmation from such service contractor(s) verifying that such a contract has been entered into and that the required service will be provided. Landlord
may enter and view the state of repair and Tenant will repair in a good and workmanlike manner according to notice in writing. 
 18.4
Cleaning. Tenant agrees at the end of each business day to leave the Premises in a reasonably clean condition for the purpose of the performance of Landlord’s cleaning services referred to herein. 

18.5 Waiver. Tenant waives all rights it may have under law to make repairs at Landlord’s expense. 

18.6 Acceptance. Except as to the construction obligations of Landlord, if any, stated in Exhibit B to this Lease, Tenant
shall accept the Premises in “as is” condition as of the date of execution of this Lease by Tenant, and subject to the punch list items referenced in Section 4.5, Tenant acknowledges that the Premises in such condition are in good and
sanitary order, condition and repair. 
 ARTICLE 19 

DESTRUCTION 
 19.1
Rights of Termination. In the event the Premises suffers (a) an “uninsured property loss” (as hereinafter defined) or (b) a property loss which cannot be repaired within one hundred eighty (180) days from the date of
destruction under the laws and regulations of state, federal, county or municipal authorities, or other authorities with jurisdiction, Landlord may terminate this Lease as of the date of the damage within twenty (20) days of written notice from
Landlord to Tenant that the damage from the casualty was an uninsured property loss or that time to restore will exceed such one hundred eighty (180) day period. In the event of a property loss to the Premises which cannot be repaired within
one hundred eighty (180) days of the occurrence thereof, Tenant shall also have the right to terminate the Lease by written notice to Landlord within twenty (20) days following notice from Landlord that the time for restoration will exceed
such time period. Notwithstanding anything to the contrary contained in this Lease, Tenant shall not have the right to terminate this Lease if the casualty or other loss or damage was caused by the negligence or intentional misconduct of Tenant or
any Tenant Entity or a party related to Tenant. For purposes of this Lease, the term “uninsured property loss” shall mean any loss arising from a peril not covered by the standard form of “All Risk” property insurance
policy. 
 19.2 Repairs. In the event of a property loss which may be repaired within one hundred eighty (180) days from the
date of the damage, or, in the alternative, in the event the parties do not elect to terminate this Lease under the terms of Section 19.1 above, then this Lease shall continue in full force and effect and Landlord shall forthwith undertake to
make such repairs to reconstitute the Premises to as near the condition as existed prior to the property loss as 

  
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practicable. Landlord shall not be required to repair or replace any damage or loss by or from fire or other cause to any panelings, decorations, partitions, additions, railings, ceilings, floor
coverings, office fixtures or any other property or improvements installed on the Premises by, or belonging to, Tenant. Such partial destruction shall in no way annul or void this Lease except that Tenant shall be entitled to a proportionate
reduction of Monthly Base Rent following the property loss and until the time the Premises are restored. Such reduction shall be based on the extent to which Tenant’s use of the Premises is impaired. So long as Tenant conducts its business in
the Premises, there shall be no abatement until the parties agree on the amount thereof. If the parties cannot agree within forty-five (45) days of the property loss, the matter shall be submitted to arbitration under the rules of the American
Arbitration Association. Upon the resolution of the dispute, the settlement shall be retroactive and Landlord shall within ten (10) days thereafter refund to Tenant any sums due in respect of the reduced rental from the date of the property
loss. Landlord’s obligations to restore shall in no way include any construction originally performed by Tenant or subsequently undertaken by Tenant, but shall include solely that property constructed by Landlord prior to commencement of the
Term hereof. Notwithstanding anything to the contrary contained in this Lease, in the event the holder of any indebtedness secured by a mortgage or deed of trust covering the Premises, Building and/or Complex requires that any insurance proceeds be
applied to such indebtedness, then Landlord shall have the right to terminate this Lease by delivering written notice of termination to Tenant within fifteen (15) days after such requirement is made by any such holder, whereupon this Lease
shall end on the date of such damage as if the date of such damage were the date originally fixed in this Lease for the expiration of the Term. 

19.3 Repair Costs. The cost of any repairs to be made by Landlord, pursuant to Section 19.2 of this Lease, shall be paid by
Landlord utilizing available insurance proceeds. Any deductible for which no insurance proceeds will be obtained under Landlord’s insurance policy shall be included within Operating Costs. 

19.4 Waiver. Tenant hereby waives all statutory or common law rights of termination in respect to any partial destruction or property
loss which Landlord is obligated to repair or may elect to repair under the terms of this Article. 
 19.5 Landlord’s Election.
In the event that the Complex or Building is destroyed to the extent of not less than thirty-three and one third percent (33 1⁄3%) of the replacement cost
thereof, Landlord may elect to terminate this Lease, whether the Premises be injured or not, in the same manner as in Section 19.1 above. In all events, a total destruction of the Complex or Building shall terminate this Lease. 

19.6 Damage Near End of Term. If at any time during the last twelve (12) months of the term of this Lease there is damage to the
Premises and the expected cost to repair is in excess of $350,000, whether or not such casualty is covered in whole or in part by insurance, either party may at its option cancel and terminate this Lease as of the date of occurrence of such damage
by giving written notice to the other of its election to do so within thirty (30) days after the date of occurrence of such damage and neither party shall have no further liability hereunder. 

  
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 ARTICLE 20 

CONDEMNATION 
 20.1
Definitions. 
 (a) “Condemnation” means (i) the exercise of any governmental power, whether by legal
proceedings or otherwise, by a condemnor and/or (ii) a voluntary sale or transfer by Landlord to any condemnor, either under threat of condemnation or while legal proceedings for condemnation are pending. 

(b) “Date of taking” means the date the condemnor has the right to possession of the property being condemned. 

(c) “Award” means all compensation, sums or anything of value awarded, paid or received on a total or partial condemnation.

 (d) “Condemnor” means any public or quasi public authority, or private corporation or individual, having the power of
condemnation. 
 20.2 Total Taking. If the Premises are totally taken by condemnation, this Lease shall terminate on the date of
taking. 
 20.3 Partial Taking; Common Areas. 

(a) If any portion of the Premises is taken by condemnation, this Lease shall remain in effect, except that Tenant can elect to terminate this
Lease if 33-1/3% or more of the total number of square feet in the Premises is taken. 
 (b) If any
part of the Common Areas of the Complex is taken by condemnation, this Lease shall remain in full force and effect so long as there is no material interference with the access to the Premises, except that if thirty percent (30%) or more of the
Common Areas is taken by condemnation, Landlord or Tenant shall have the election to terminate this Lease pursuant to this Section. 
 (c)
If fifty percent (50%) or more of the Building in which the Premises are located is taken, Landlord shall have the election to terminate this Lease in the manner prescribed herein. 

20.4 Termination or Abatement. If either party elects to terminate this Lease under the provisions of Section 20.3 (such party is
hereinafter referred to as the “Terminating Party”), it must terminate by giving notice to the other party (the “Nonterminating Party”) within thirty (30) days after the nature and extent of the taking have
been finally determined (the “Decision Period”). The Terminating Party shall notify the Nonterminating Party of the date of termination, which date shall not be earlier than one hundred twenty (120) days after the Terminating
Party has notified the Nonterminating Party of its election to terminate nor later than the date of taking. If Notice of Termination is not given within the Decision Period, the Lease shall continue in full force and effect except that Monthly Base
Rent shall be reduced by subtracting therefrom an amount calculated by multiplying the Monthly Base Rent in effect prior to the taking by a 

  
 40 

 
fraction the numerator of which is the number of square feet taken from the Premises and the denominator of which is the number of square feet in the Premises prior to the taking. 

20.5 Restoration. If there is a partial taking of the Premises and this Lease remains in full force and effect pursuant to this
Article, Landlord, at its cost, shall accomplish all necessary restoration so that the Premises is returned as near as practical to its condition immediately prior to the date of the taking, but in no event shall Landlord be obligated to expend more
for such restoration than the extent of funds actually paid to Landlord by the condemnor. 
 20.6 Award. Any award arising from the
condemnation or the settlement thereof shall belong to and be paid to Landlord except that Tenant shall receive from the award compensation for the following if specified in the award by the condemning authority, so long as it does not reduce
Landlord’s award in respect of the real property: Tenant’s trade fixtures, tangible personal property, goodwill, loss of business and relocation expenses. At all events, Landlord shall be solely entitled to all award in respect of the real
property, including the bonus value of the leasehold. Tenant shall not be entitled to any award until Landlord has received the above sum in full. 

ARTICLE 21 

ASSIGNMENT AND SUBLETTING 

21.1 Lease is Personal. The purpose of this Lease is to transfer possession of the Premises to Tenant for Tenant’s personal use in
return for certain benefits, including rent, to be transferred to the Landlord. Tenant acknowledges and agrees that it has entered into this Lease in order to occupy the Premises for its own personal use and not for the purpose of obtaining the
right to assign or sublet the leasehold to others. 
 21.2 “Transfer of the Premises” Defined. Except for any Permitted
Transfer described in Section 21.5 hereof, the terms “Transfer of the Premises” or “Transfer” as used herein shall include any of the following, whether voluntary or involuntary and whether effected by death,
operation of law or otherwise: 
 (a) An assignment of all or any part this Lease or subletting of all or any part the Premises or transfer
of possession, or right of possession or contingent right of possession of all or any portion of the Premises including, without limitation, concession, mortgage, deed of trust, devise, hypothecation, agency, license, franchise or management
agreement, or the occupancy or use by any other person (the agents and servants of Tenant excepted) of any portion of the Premises. 
 (b)
If Tenant is a partnership, limited liability company or other entity other than a corporation described in Section 21.2(c) below: 

(1) A change in ownership effected voluntarily, involuntarily, or by operation of law of fifty percent (50%) or more of the partners or
members or fifty percent (50%) or more in the aggregate of the partnership or membership interests, whether in a single transaction or series of transactions over a period of time; or 

  
 41 

 (2) The sale, mortgage, hypothecation, pledge or other encumbrance at any time of more than an
aggregate of fifty percent (50%) in the aggregate of the value of Tenant’s assets; or 
 (3) The dissolution of the partnership
or limited liability company without its immediate reconstitution. 
 (c) If Tenant is a closely held corporation (i.e., one whose
stock is not publicly held and not traded through an exchange or over the counter): 
 (1) The sale or other transfer of more than an
aggregate of fifty percent (50%) of the voting shares of Tenant or more in the aggregate, whether in a single transaction or series of transactions over a period of time; 

(2) The sale, mortgage, hypothecation, pledge or other encumbrance at any time of more than an aggregate of fifty percent (50%) in the
aggregate of the value of Tenant’s assets; or 
 (3) The dissolution, merger, consolidation, or other reorganization of Tenant. 

21.3 No Transfer Without Consent. Except for a Permitted Transfer described in Section 21.5 hereof, Tenant shall not suffer a
Transfer of the Premises or any interest therein, or any part thereof, or any right or privilege appurtenant thereto without the prior written consent of Landlord, and a consent to one Transfer of the Premises shall not be deemed to be a consent to
any subsequent Transfer of the Premises. Any Transfer of the Premises without such consent shall be void, and shall, at the option of Landlord, terminate this Lease. Any Transfer of the Premises without such consent shall (i) be voidable, and
(ii) terminate this Lease, in either case, at the option of Landlord. The consent by Landlord to any Transfer shall not include consent to the assignment or transferring of any lease renewal option rights or space option rights of the Premises,
special privileges or extra services granted to Tenant by this Lease, or addendum or amendment thereto or letter of agreement (and such options, rights, privileges or services shall terminate upon such assignment), unless Landlord specifically
grants in writing such options, rights, privileges or services to such assignee or subtenant. 
 21.4 When Consent Granted. The
consent of Landlord to a Transfer may not be unreasonably withheld, conditioned or delayed, provided that it is agreed to be reasonable for Landlord to consider any of the following reasons, which list is not exclusive, in electing to deny consent:

 (a) The financial strength of the proposed transferee at the time of the proposed Transfer is not sufficient in light of the obligations
of such proposed Transfer; 
 (b) A proposed transferee whose occupation of the Premises would cause a diminution in the reputation of the
Complex or the other businesses located therein; 
 (c) A proposed transferee whose impact or affect on the common facilities or the
utility, efficiency or effectiveness of any utility or telecommunication system serving the 

  
 42 

 
Building or the Complex or the other occupants of the Complex would be adverse, disadvantageous or require improvements or changes in any utility or telecommunication capacity currently serving
the Building or the Complex; 
 (d) A proposed transferee whose occupancy will require a variation in the terms of this Lease (including,
without limitation, a variation in the use clause) or which otherwise adversely affects any interest of Landlord; 
 (e) The existence of
any default by Tenant (beyond applicable notice and cure periods) under any provision of this Lease; 
 (f) A proposed transferee who is or
is likely to be, or whose business is or is likely to be, subject to compliance with additional laws or other governmental requirements beyond those to which Tenant or Tenant’s business is subject; 

(g) If at the relevant time Landlord has space available for lease comparable to the space being offered by Tenant, either the proposed
transferee, or any person or entity which directly or indirectly, controls, is controlled by, or is under common control with, the proposed transferee or an affiliate of the proposed transferee, (i) occupies space in the Building at the time of
the request for consent, or (ii) is negotiating with Landlord to lease space in the Building or in the Complex at such time; 
 (h) the
proposed Transferee is a governmental agency or unit, a non-profit or charitable entity or organization or an existing tenant in the Complex; 

(i) Landlord otherwise determines that the proposed Transfer would have the effect of decreasing the value of the Building or the Complex, or
increasing the expenses associated with operating, maintaining and repairing the Building or the Complex; 
 (j) the proposed Transferee
will use, store or handle Hazardous Materials (defined below) in or about the Premises of a type, nature or quantity not then acceptable to Landlord; or 

(k) the portion of the Premises to be sublet or assigned is irregular in shape with inadequate means of ingress and egress. 

21.5 Permitted Transfer. Notwithstanding the foregoing, Landlord’s consent is not required for any Permitted Transfer (as
hereinafter defined), provided the following conditions are met: 
 (a) At least ten (10) business days before the Transfer (unless
disclosure of the same is restricted by applicable law, in which case no later than three (3) business days following the Transfer), Landlord receives written notice of the Transfer (as well as any documents or information reasonably necessary
to show the consummation of the Permitted Transfer); 
 (b) The Permitted Transfer is not a subterfuge by Tenant to avoid its obligations
under this Lease; 

  
 43 

 (c) If the Permitted Transfer is an assignment or sale of Tenant’s assets or merger of
Tenant into a successor entity, the Transferee assumes in writing all of Tenant’s obligations under this Lease relating to the Premises; and 

(d) The Transferee (if such Transferee is an assignee) has a tangible net worth, as evidenced by financial statements delivered to Landlord
and certified by an independent certified public accountant or such Transferee’s chief financial officer in accordance with generally accepted accounting principles that are consistently applied (“Net Worth”), at least equal to
Tenant’s Net Worth either immediately before the Transfer or as of the date of this Lease, whichever is greater. 
 For purposes
hereof, the term “Permitted Transfer” shall mean any Transfer to an entity that (i) is an Affiliate of Tenant, (ii) purchases substantially all of Tenant’s assets, or (iii) is the surviving entity in the event of
any merger or consolidation of Tenant with such surviving entity. For purposes hereof “Affiliate” means any entity that controls, is controlled by, or is under common control with Tenant. “Control” means the direct or
indirect ownership of more than fifty percent (50%) of the voting securities of an entity or possession of the right to vote more than fifty percent (50%) of the voting interest in the ordinary direction of the entity’s affairs. In
addition, a sale or transfer of the memberships, interests, shares, or stock of Tenant shall be deemed a Permitted Transfer if (1) such sale or transfer occurs in connection with any bona fide financing or capitalization for the benefit
of Tenant, or (2) Tenant is, or in connection with the proposed transfer becomes, a publicly traded entity. Landlord shall have no right to terminate the Lease in connection with, and shall have no right to any sums or other economic
consideration resulting from, any Permitted Transfer. 
 21.6 Procedure for Obtaining Consent. In the event Tenant desires to sublet,
or permit such occupancy of, the Premises, or any portion thereof, or assign this Lease, other than in connection with a Permitted Transfer, Tenant shall give written notice thereof to Landlord at least fifteen (15) days but no more than one
hundred eighty (180) days prior to the proposed commencement date of such subletting or assignment, which notice shall set forth the name of the proposed subtenant or assignee, the relevant terms of any sublease or assignment and copies of
financial reports and other relevant financial information of the proposed subtenant or assignee. With respect to a Transfer requiring Landlord’s consent, Landlord need not commence its review of any proposed Transfer, or respond to any request
by Tenant with respect to such, unless and until it has received from Tenant adequate descriptive information concerning the business to be conducted by the proposed transferee, the transferee’s financial capacity, and such other information as
may reasonably be required in order to form a prudent judgment as to the acceptability of the proposed Transfer, including, without limitation, the following: 

(a) The past two years’ Federal Income Tax returns of the proposed transferee (or in the alternative the past two years’ audited
annual Balance Sheets and Profit and Loss statements, certified correct by a Certified Public Accountant); 
 (b) Banking references of the
proposed transferee; 
 (c) A resume of the business background and experience of the proposed transferee; 

  
 44 

 (d) At least two (2) business references for the proposed transferee; and 

(e) An executed copy of the instrument by which Tenant proposes to effectuate the Transfer. 

21.7 Recapture. By written notice to Tenant (the “Termination Notice”) within thirty (30) days following
submission to Landlord by Tenant of the information specified in Section 21.6, Landlord may (1) terminate this Lease in the event of an assignment of this Lease or sublet of the entire Premises, or (2) terminate this Lease as to the
portion of the Premises to be sublet, if the sublet is to be of less than the entire Premises, unless Tenant withdraws its request for consent within five (5) business days following receipt of the Termination Notice. If Landlord elects to
terminate under the provisions hereof, and the area to be terminated is less than the entire Premises, an amendment to this Lease shall be executed in which Tenant’s obligations for rent and other charges shall be reduced in proportion to the
reduction in the size of the Premises caused thereby by restating the description of the Premises, and its monetary obligations hereunder shall be reduced by multiplying such obligations by a fraction, the numerator of which is the Rentable Area of
the Premises offered for sublease and the denominator of which is the Rentable Area of the Premises immediately prior to such termination, as determined by Landlord in its sole and absolute discretion. 

21.8 Reasonable Restriction. The restrictions on Transfer described in this Lease are acknowledged by Tenant to be reasonable for all
purposes, including, without limitation, the provisions of California Civil Code (the “Code”) Section 1951.4(b)(2). Tenant expressly waives any rights which it might otherwise be deemed to possess pursuant to applicable law,
including, without limitation, Section 1997.040 of the Code, to limit any remedy of Landlord pursuant to Section 1951.2 or 1951.4 of the Code by means of proof that enforcement of a restriction on use of the Premises would be unreasonable.

 21.9 Effect of Transfer. If Landlord consents to a Transfer and does not elect to recapture as provided in Section 21.7, the
following conditions shall apply: 
 (a) Each and every covenant, condition or obligation imposed upon Tenant by this Lease and each and
every right, remedy or benefit afforded Landlord by this Lease shall not be impaired or diminished as a result of such Transfer. 
 (b)
Tenant shall pay to Landlord on a monthly basis, fifty percent (50%) of all rent, additional rent or other consideration received from such transferee in connection with the Transfer in excess of the Rent payable by Tenant under this Lease
during the term of the Transfer, on a per rentable square foot basis if less than all of the Premises is transferred, after deducting all reasonable expenses actually incurred by Tenant in connection therewith for (i) improvements to the
Premises made and paid for by Tenant in connection with the Transfer, (ii) reasonable brokerage commissions in connection with the Transfer paid by Tenant to unaffiliated third party licensed real estate brokers, (iii) reasonable legal
fees incurred in connection with the Transfer, and (iv) any fees or charges paid to Landlord in connection with the request for consent to Transfer. The amount so derived shall be paid with Tenant’s payment of Minimum Monthly Rent. 

  
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 (c) No Transfer, whether or not consent of Landlord is required hereunder, shall relieve Tenant
of its primary obligation to pay the rent and to perform all other obligations to be performed by Tenant hereunder. The acceptance of rent by Landlord from any person shall not be deemed to be a waiver by Landlord of any provision of this Lease or
to be a consent to any Transfer of the Premises. 
 (d) If Landlord consents to a sublease, such sublease shall not extend beyond the
expiration of the Term of this Lease. 
 (e) No Transfer shall be valid and no transferee shall take possession of the Premises or any part
thereof unless, Tenant shall deliver to Landlord, at least ten (10) days prior to the effective date of such Transfer, a duly executed duplicate original of the Transfer instrument in form reasonably satisfactory to Landlord which provides that
(i) the assignee assumes Tenant’s obligations for the payment of rent and for the full and faithful observance and performance of the covenants, terms and conditions contained herein, (ii) such transferee will, at Landlord’s
election, attorn directly to Landlord in the event Tenant’s Lease is terminated for any reason on the terms set forth in the instrument of transfer and (iii) such instrument of transfer contains such other assurances as Landlord reasonably
deems necessary. 
 21.10 Costs. Tenant shall reimburse Landlord as additional rent for Landlord’s reasonable costs and
attorneys’ fees incurred in conjunction with the processing and documentation of any proposed Transfer of the Premises, whether or not consent is granted, not to exceed $2,000.00, unless Tenant or its Transferee requests changes to this Lease
or Landlord’s form of consent, in which case such monetary limitation shall not apply. The reference to changes in this Lease or Landlord’s form of consent shall not be deemed or constructed as an agreement, commitment or assurance by
Landlord that any changes will be made. 
 21.11 Restrictions on Marketing the Space. Tenant may not promote or advertise the
availability of the Premises or any part thereof unless Landlord has approved Tenant’s advertising or promotional materials in writing, which approval shall not be unreasonably withheld, conditioned or delayed. 

ARTICLE 22 
 ENTRY
BY LESSOR 
 22.1 Rights of Landlord. Tenant shall permit Landlord and Landlord’s agents and any mortgagee under a mortgage
or beneficiary under a deed of trust encumbering the Building containing the Premises and such party’s agents to enter the Premises at all reasonable times, following reasonable prior notice for the purpose of (a) inspecting the same,
(b) maintaining the Building, (c) making repairs, replacements, alterations or additions to any portion of the Building, including the erection and maintenance of such scaffolding, canopies, fences and props as may be required,
(d) posting notices of non-responsibility for alterations, additions or repairs, (e) placing upon the Building any usual or ordinary “for sale” signs and showing the space to prospective purchasers, investors and lenders, without
any rebate of rent and without any liability to Tenant for any loss of occupation or quiet enjoyment of the Premises thereby occasioned, and (f) placing on the Premises any “to let” or “to lease” signs and marketing and
showing the 

  
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Premises to prospective tenants during the last twelve months of the Term. This Section in no way affects the maintenance obligations of the parties hereto. 

ARTICLE 23 
 SIGNS

 23.1 Lobby and Suite Signage. At Tenant’s expense, Landlord will include Tenant’s name in the directory of the lobby
in the Building containing the Premises, and install a sign identifying Tenant’s name next to the main entrance door to the Premises, which sign will be consistent with the Landlord’s standard Building signage for such purposes. Any
changes to Tenant’s name or its listing in such directory shall also be at Tenant’s expense. 
 23.2 Approval, Installation and
Maintenance. Subject to Section 23.1 above, Tenant shall not place on the Premises or on the Building or Common Areas of the Complex, any exterior signs or advertisements nor any interior signs or advertisements that are visible from the
exterior of the Premises, without Landlord’s prior written consent, which Landlord reserves the right to withhold for any aesthetic or other reason in its sole and absolute discretion. The cost of installation and regular maintenance of any
such signs approved by Landlord shall be at the sole expense of Tenant. At the termination of this Lease, or any extension thereof, Tenant shall remove all its signs, and all damage caused by such removal shall be repaired at Tenant’s expense.

 ARTICLE 24 

DEFAULT 
 24.1
Definition. The occurrence of any of the following shall constitute a material event of default and breach of this Lease by Tenant: 

(a) Payment. Any failure by Tenant to pay the rent or to make any other payment required to be made by Tenant hereunder when due;
provided, however, that not more frequently than twice each calendar year, Tenant shall not be in default for failure to pay Rent or any other sum unless Tenant fails to make such payment within five (5) days after receipt of written notice of
such failure from Landlord. The foregoing notice and cure period shall not be deemed a waiver or release of the obligation to pay late charges and interest for payments not made when due; or 

(b) Other Covenants. A failure by Tenant to observe and perform any other provision of this Lease to be observed or performed by
Tenant, where such failure continues for ten (10) days after written notice thereof by Landlord to Tenant; provided, however, that if the nature of the default is such that the same cannot reasonably be cured within the ten (10) day period
allowed, Tenant shall not be deemed to be in default if Tenant shall, within such ten (10) day period, commence to cure and thereafter diligently prosecute the same to completion. Notwithstanding the foregoing, any default by Tenant to comply
with the terms and conditions contained in Article 15 (Liability and Other Insurance), Article 16 (Insurance Policy Requirements and Insurance Defaults), Article 32 (Estoppel Certificates) and/or Section 32.2 (Financial Statements and Credit
Reports) within the time period for performance set forth in 

  
 47 

 
such provisions, where such failure continues for five (5) days after written notice of such failure by Landlord to Tenant; or 

(c) Receivership. Either (1) the appointment of a receiver (except a receiver appointed at the instance or request of Landlord) to
take possession of all or substantially all of the assets of Tenant, or (2) a general assignment by Tenant for the benefit of creditors, or (3) any action taken or suffered by Tenant under any insolvency or bankruptcy act shall constitute
a breach of this Lease by Tenant. In such event, Landlord may, at its option, declare this Lease terminated and forfeited by Tenant, and Landlord shall be entitled to immediate possession of the Premises. Upon such notice of termination, this Lease
shall terminate immediately and automatically by its own limitation. 
 ARTICLE 25 

REMEDIES UPON DEFAULT 

25.1 Termination and Damages. In the event of any default by Tenant, then in addition to any other remedies available to Landlord
herein or at law or in equity, Landlord shall have the immediate option to terminate this Lease and all rights of Tenant hereunder by giving written notice of such intention to terminate. In the event that Landlord shall elect to so terminate this
Lease, then Landlord may recover from Tenant: 
 (a) The worth at the time of award of any unpaid rent which had been earned at the time of
such termination; plus 
 (b) The worth at the time of award of the amount by which the unpaid rent which would have been earned after
termination until the time of award exceeds the amount of such rental loss Tenant proves could have been reasonably avoided; plus 
 (c) The
worth at the time of award of the amount by which the unpaid rent for the balance of the term after the time of award exceeds the amount of such rental loss that Tenant proves could be reasonably avoided; plus 

(d) Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its
obligations under this Lease or which in the ordinary course of events would be likely to result therefrom; and 
 (e) At Landlord’s
election, such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by the applicable law in the state in which the Premises are located. 

25.2 Definition. As used in subsections 25.1(a) and (b) above, the “worth at the time of award” is computed by allowing
interest at the rate of ten percent (10%) per annum. As used in Section 25.1(c) above, the “worth at the time of award” is computed by discounting such amount at the discount rate of the Federal Reserve Bank for the region in
which the Complex is located at the time of award plus one percent (1%). 

  
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 25.3 Personal Property. In the event of a default by Tenant, Landlord shall also have the
right and option, with or without terminating this Lease, to do any one or combination of the following: 
 (a) to reenter the Premises and
remove all persons and property from the Premises; or 
 (b) to require Tenant to forthwith remove all of Tenant’s fixtures, furniture,
equipment, improvements, additions, alterations and other personal property from the Premises. 
 Landlord shall have the sole right to take
exclusive possession of such property and to use it, rent, or charge free, until all defaults are cured. If Landlord shall remove property from the Premises, Landlord may, in its sole and absolute discretion, store such property in the Complex, in a
public warehouse or elsewhere. All costs incurred by Landlord under this Section, including, without limitation, those for removal and storage (including, without limitation, charges imposed by Landlord for storage within the Complex), shall be at
the sole cost of and for the account of Tenant. The rights stated herein are in addition to Landlord’s rights described in Article 17. 

25.4 Recovery of Rent; Reletting. 

(a) In the event of the vacation or abandonment of the Premises by Tenant or in the event that Landlord shall elect to reenter as provided in
Section 25.3 above, or shall take possession of the Premises pursuant to legal proceeding or pursuant to any notice provided by law, then if Landlord does not elect to terminate this Lease as provided in Section 25.1 above, this Lease
shall continue in effect for so long as Landlord does not terminate Tenant’s right to possession, and Landlord may enforce all its rights and remedies under this Lease, including, without limitation, Landlord’s right from time to time,
without terminating this Lease, to either recover all rental as it becomes due or relet the Premises or any part thereof for such term or terms and at such rental or rentals and upon such other terms and conditions as Landlord, in its sole
discretion, may deem advisable with the right to make alterations and repairs to the Premises. Acts of maintenance or preservation or efforts to relet the Premises or the appointment of a receiver upon initiation of Landlord or other legal
proceeding granting Landlord or its agent possession to protect Landlord’s interest under this Lease shall not constitute a termination of Tenant’s right to possession. 

(b) In the event that Landlord shall elect to so relet, then rentals received by Landlord from such reletting shall be applied: first, to the
payment of any indebtedness other than rent due hereunder from Tenant to Landlord; second, to the payment of any cost of such reletting; third, to the payment of the cost of any alterations and repairs to the Premises; fourth, to the payment of rent
due and unpaid hereunder; and the residue, if any, shall be held by Landlord and applied in payment of future rent as the same may become due and payable hereunder. Should that portion of such rentals received from such reletting during any month,
which is applied by the payment of rent hereunder, be less than the rent payable during that month by Tenant hereunder, then Tenant shall pay such deficiency to Landlord immediately upon demand therefor by Landlord. Such deficiency shall be
calculated and paid monthly. Tenant shall also pay to Landlord, as soon as ascertained, any costs and expenses incurred by 

  
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Landlord in such reletting or in making such alterations and repairs not covered by the rentals received from such reletting. 

(c) No reentry or taking possession of the Premises or any other action under this Section shall be construed as an election to terminate this
Lease unless a written notice of such intention be given to Tenant or unless the termination thereof be decreed by a court of competent jurisdiction. Notwithstanding any reletting without termination by Landlord because of any default by Tenant,
Landlord may at any time after such reletting elect to terminate this Lease for any such default. 
 (d) Landlord has the remedy described
in California Civil Code Section 1951.4 (Landlord may continue Lease in effect after Tenant’s breach and abandonment and recover rent as it becomes due, if Tenant has right to sublet or assign, subject only to reasonable limitations). 

25.5 No Waiver. Efforts by Landlord to mitigate the damages caused by Tenant’s default in this Lease shall not constitute a waiver
of Landlord’s right to recover damages hereunder, nor shall Landlord have any obligation to mitigate damages hereunder. 
 25.6
Curing Defaults. Should Tenant fail to repair, maintain, and/or service the Premises, or any part or contents thereof at any time or times, or perform any other obligations imposed by this Lease or otherwise, then after having given Tenant
reasonable notice of the failure or failures and a reasonable opportunity which in no case shall exceed thirty (30) days, to remedy the failure, Landlord may perform or contract for the performance of the repair, maintenance, or other Tenant
obligation, and Tenant shall pay Landlord for all direct and indirect costs incurred in connection therewith within ten (10) days of receiving a bill therefor from Landlord. 

25.7 Cumulative Remedies. The various rights, options, election powers, and remedies of Landlord contained in this Article and
elsewhere in this Lease shall be construed as cumulative and no one of them exclusive of any others or of any legal or equitable remedy which Landlord might otherwise have in the event of breach or default, and the exercise of one right or remedy by
Landlord shall not in any way impair its right to any other right or remedy. 
 ARTICLE 26 

BANKRUPTCY 
 26.1
Bankruptcy Events. If at any time during the term of this Lease there shall be filed by or against Tenant in any court pursuant to any statute either of the United States or of any state a petition in bankruptcy or insolvency or for
reorganization or for the appointment of a receiver or trustee of all or a portion of Tenant’s property, or if a receiver or trustee takes possession of any of the assets of Tenant, or if the leasehold interest herein passes to a receiver, or
if Tenant makes an assignment for the benefit of creditors or petitions for or enters into an arrangement (any of which are referred to herein as a “bankruptcy event”), then the following provisions shall apply: 

(a) Assume or Reject. At all events any receiver or trustee in bankruptcy or Tenant as debtor in possession (“debtor”)
shall either expressly assume or reject this Lease 

  
 50 

 
within the earlier of one hundred twenty (120) days following the filing of a petition in bankruptcy or entry of an “Order for Relief” or such earlier period of time provided by
law. 
 (b) Cure. In the event of an assumption of the Lease by a debtor, receiver or trustee, such debtor, receiver or trustee shall
immediately after such assumption (1) cure any default or provide adequate assurances that defaults will be promptly cured; and (2) compensate Landlord for actual pecuniary loss or provide adequate assurances that compensation will be made
for actual pecuniary loss; and (3) provide adequate assurance of future performance. 
 (c) Adequate Assurance. For the purposes
of Section 26.1(b), adequate assurance of future performance of all obligations under this Lease shall include, but is not limited to: 

(1) written assurance that rent and any other consideration due under the Lease shall first be paid before any other of Tenant’s costs
of operation of its business in the Premises is paid; 
 (2) written agreement that assumption of this Lease will not cause a breach of any
provision hereof including, but not limited to, any provision relating to use or exclusivity in this or any other Lease, or agreement relating to the Premises, or if such a breach is caused, the debtor, receiver or trustee will indemnify Landlord
against such loss (including costs of suit and attorneys’ fees), occasioned by such breach; 
 (d) Landlord’s Obligation.
Where a default exists under the Lease, the party assuming the Lease may not require Landlord to provide services or supplies incidental to the Lease before its assumption by such trustee or debtor, unless Landlord is compensated under the terms of
the Lease for such services and supplies provided before the assumption of such Lease. 
 (e) Assignment. The debtor, receiver, or
trustee may assign this Lease only if adequate assurance of future performance by the assignee is provided, whether or not there has been a default under the Lease. Any consideration paid by any assignee in excess of the rental reserved in the Lease
shall be the sole property of, and paid to, Landlord. Upon assignment by the debtor or trustee, the obligations of the Lease shall be deemed to have been assumed, and the assignee shall execute an assignment agreement on request of Landlord. 

(f) Fair Value. Landlord shall be entitled to the fair market value for the Premises and the services provided by Landlord (but in no
event less than the rental reserved in the Lease) subsequent to the commencement of a bankruptcy event. 
 (g) Reservation of Rights.
Landlord specifically reserves any and all remedies available to Landlord in Article 25 hereof or at law or in equity in respect of a bankruptcy event by Tenant to the extent such remedies are permitted by law. 

ARTICLE 27 

SURRENDER OF LEASE 
 27.1
No Merger. The voluntary or other surrender of this Lease by Tenant, or a mutual cancellation thereof, shall not work as a merger, and shall, at the option of Landlord, terminate 

  
 51 

 
all or any existing subleases or subtenancies, or may, at the option of Landlord, operate as an assignment to it of any or all such subleases or subtenancies. 

ARTICLE 28 

LANDLORD’S EXCULPATION 

28.1 Limited Liability. Redress for any claim against Landlord under this Lease shall be limited to and enforceable only against and to
the extent of Landlord’s interest in the Building. The obligations of Landlord shall not be personally binding on, nor shall any resort be had to the private properties of, any of its or its investment manager’s trustees, directors,
officers, partners, beneficiaries, members, stockholders, employees, or agents, and in no case shall Landlord be liable to Tenant hereunder for any lost profits, damage to business, or any form of special, indirect or consequential damages. 

ARTICLE 29 

ATTORNEYS’ FEES 
 29.1
Attorneys’ Fees. In the event of any litigation or arbitration (if each party in its sole and absolute discretion elects to use arbitration) proceeding between the parties with respect to this Lease, then all costs and expenses,
including without limitation, all reasonable professional fees such as appraisers’, accountants’ and attorneys’ fees, incurred by the prevailing party therein shall be paid or reimbursed by the other party. The “prevailing
party” means the party determined by the court or arbitrator (if the parties elected to use arbitration) to have most nearly prevailed, even if such party did not prevail in all matters, not necessarily the one in whose favor a judgment is
rendered. If, on account of any breach or default by Tenant in Tenant’s obligations under the terms and conditions of this Lease, it shall become necessary or appropriate for Landlord to employ or consult with an attorney or collection agency
concerning or to enforce or defend any of Landlord’s rights or remedies arising under this Lease or to collect any sums due from Tenant, Tenant agrees to pay all costs and fees so incurred by Landlord, including, without limitation, reasonable
attorneys’ fees and costs. Should Landlord be named as a defendant or requested or required to appear as a witness or produce any documents in any suit brought by Tenant against any other party or against Tenant in connection with or arising
out of Tenant’s occupancy hereunder, Tenant shall pay to Landlord its costs and expenses incurred in such suit, including without limitation, all reasonable professional fees such as appraisers’, accountants’ and attorneys’ fees.
The provisions of this Section shall survive the expiration or termination of this Lease. 
 ARTICLE 30 

NOTICES 
 30.1
Writing. All notices, demands and requests required or permitted to be given or made under any provision of this Lease shall be in writing and shall be given or made by personal service or by mailing same by registered or certified mail,
return receipt requested, postage prepaid, or overnight by Fed Ex or reputable courier which provides written evidence of delivery or other means of confirmation of delivery (such as computer confirmation by Fed Ex), or by facsimile with facsimile
confirmation that the notice was sent, addressed to the respective 

  
 52 

 
party at the address set forth in Section 1.2 of this Lease or at such other address as the party may from time to time designate, by a written notice sent to the other in the manner
aforesaid. 
 30.2 Effective Date. Any such notice, demand or request (“notice”) shall be deemed given or made on
the third day after the date so mailed. Notwithstanding the foregoing, notice given by personal delivery or by fax to the party at its address or fax number as aforesaid shall be deemed given on the day on which delivery is made or the fax is sent,
respectively. Notice given overnight by a reputable courier service which provides written evidence of delivery shall be deemed given on the business day immediately following deposit with the courier service. 

30.3 Authorization to Receive. Each person and/or entity whose signature is affixed to this Lease as Tenant or as guarantor of
Tenant’s obligations (“obligor”) designates such other obligor its agent for the purpose of receiving any notice pertaining to this Lease or service of process in the event of any litigation or dispute arising from any
obligation imposed by this Lease. 
 ARTICLE 31 

SUBORDINATION AND FINANCING PROVISIONS 

31.1 Priority of Encumbrances. This Lease is subordinate to any ground lease, mortgage, deed of trust or any other hypothecation for
security now or hereafter placed upon the real property of which the Premises are a part and to any and all advances made on the security thereof and to all renewals, modifications, consolidations, replacements and extensions thereof. If any
mortgagee, trustee or ground lessor shall elect to have this Lease prior to the lien of its mortgage, deed of trust or ground lease, and shall give written notice thereof to Tenant, this Lease shall be deemed prior to such mortgage, deed of trust or
ground lease, whether this Lease is dated prior or subsequent to the date of said mortgage, deed of trust or ground lease or the date of recording thereof. 

31.2 Execution of Documents. Tenant agrees to execute any documents required to further effectuate such subordination or to make this
Lease prior to the lien of any mortgage, deed of trust or ground lease, as the case may be, if requested by Landlord or any lender. It is understood by all parties that Tenant’s failure to execute the subordination documents referred to above
may cause Landlord serious financial damage by causing the failure of a financing or sale transaction. 
 31.3 Attornment. If the
holder of any ground lease, mortgage, deed of trust or security described above (or its successor-in-interest), enforces its remedies provided by law or under the pertinent mortgage, deed of trust or security instrument and succeeds to
Landlord’s interest in the Premises, Tenant shall, upon request of any person succeeding to the interest of such lender as result of such enforcement, attorn to and recognize as its landlord and become the Tenant of said successor-in-interest
without change in the terms or other provisions of this Lease or without the execution of any further instrument by Tenant, provided, however, that said successor-in-interest shall not be (i) bound by any payment of rent for more than thirty
(30) days in advance, except prepayment in the nature of security for the performance by Tenant of its obligations under this Lease, (ii) liable for any act or omission of any previous landlord (including Landlord), provided that as
successor landlord it shall be obligated to cure any continuing default of the prior landlord 

  
 53 

 
of which it has received prior written notice and shall be liable for acts or omissions accruing or arising after such successor’s succession to the position of landlord and commencement of
control and management of the Property, (iii) subject to any offset, defense, recoupment or counterclaim that Tenant may have given to any previous landlord (including Landlord), or (iv) liable for any deposit that Tenant may have given to
any previous landlord (including Landlord) that has not, as such, been transferred to said successor-in-interest. Within ten (10) days after receipt of request by said successor-in-interest, Tenant shall execute and deliver an instrument or
instruments confirming such attornment, including a non-disturbance, attornment and subordination agreement in a form required by any such successor-in-interest. 

31.4 Notice and Right to Cure Default. Tenant agrees to give any mortgagee(s) and/or trust deed holders, by registered mail, a copy of
any notice of default served upon Landlord, provided that prior to such notice Tenant has been notified, in writing (by way of Notice of Assignment of Rents and Leases, or otherwise), of the address of such mortgagees and/or trust deed holders.
Tenant further agrees that if Landlord shall have failed to cure such default within the time provided for in this Lease or within a reasonable period of time after Landlord’s receipt of such notice of such failure if no specific period of time
is provided in this Lease, then the mortgagees and/or trust deed holders shall have an additional thirty (30) days within which to cure such default or, if such default cannot be cured within that time, then such additional time as may be
necessary if, within such thirty (30) days, any mortgagee and/or trust deed holder has commenced and is diligently pursuing the remedies necessary to cure such default (including but not limited to commencement of foreclosure proceedings, if
necessary to effect such cure), in which event this Lease shall not be terminated while such remedies are being so diligently pursued. 

31.5 Non-Disturbance. Landlord has informed Tenant that the Project is currently encumbered by a deed of trust (the “Security
Instrument”). Landlord shall use reasonable efforts to cause the beneficiary (or its servicer) of the existing Security Instrument that encumbers the Project as of the date hereof to issue its standard subordination, non-disturbance and
attornment agreement (“SNDA”), pursuant to which such beneficiary agrees to recognize this Lease in the event of default under such Security Instrument or sale under such Security Instrument, so long as Tenant is not in default
hereunder. Tenant shall be solely responsible for paying any costs and expenses incurred by Landlord as a result of Tenant’s requesting changes to the beneficiary’s standard form of such SNDA. Obtaining the SNDA is not a condition
precedent or subsequent to the Lease. The failure of such lender to issue its SNDA shall not relieve Tenant of any of its obligations under the Lease or constitute a breach or default by Landlord. 

ARTICLE 32 

ESTOPPEL CERTIFICATES 

32.1 Execution by Tenant. Within ten (10) days after receipt of written request by Landlord, Tenant shall execute and deliver to
Landlord an estoppel certificate acknowledging such facts regarding this Lease as Landlord may reasonably require, including without limitation, that to the extent of Tenant’s knowledge (i) this Lease is in full force and effect, binding
and enforceable in accordance with its terms and unmodified (or if modified, specifying the written modification documents); (ii) no default exists on the part of Landlord or Tenant under this Lease; (iii) there are no events which with
the passage of time, or the giving of notice, or both, 

  
 54 

 
would create a default under this Lease; (iv) no rent in excess of one month’s rent has been paid in advance; (v) Tenant has not received any written notice of any other sale,
assignment, transfer, mortgage or pledge of this Lease or the rent due hereunder; and (vi) Tenant has no defense, setoff, recoupment or counterclaim against Landlord. Any such estoppel certificate may be relied upon by Landlord, any lender and
any prospective purchaser of the Building or Complex or any interest therein. Failure to comply with this Article shall be a material breach of this Lease by Tenant giving Landlord all rights and remedies under this Lease, as well as a right to
damages caused by the loss of a loan or sale which may result from such failure by Tenant. 
 32.2 Financial Statements and Credit
Reports. At Landlord’s request, Tenant shall deliver to Landlord a copy, certified by an officer of Tenant as being a true and correct copy, of Tenant’s most recent audited financial statement, or, if unaudited, certified by
Tenant’s chief financial officer as being true, complete and correct in all material respects. Tenant hereby authorizes Landlord to obtain one or more credit reports on Tenant at any time, and shall execute such further authorizations as
Landlord may reasonably require in order to obtain a credit report. 
 ARTICLE 33 

MISCELLANEOUS PROVISIONS 

33.1 Effect of Waiver. The waiver by Landlord or Tenant of any breach of any Lease provision by the other party shall not be deemed to
be a waiver of such Lease provision or any subsequent breach of the same or any other term, covenant or condition therein contained. The subsequent acceptance of rent hereunder by Landlord shall not be deemed to be a waiver of any preceding breach
by Tenant of any provision of this Lease, other than the failure of Tenant to pay the particular rental so accepted, regardless of Landlord’s knowledge of such preceding breach at the time of acceptance of such rent. Any failure by Landlord or
Tenant to insist upon strict performance by the other of this Lease of any of the terms and provisions of the Lease or any guaranty of this Lease shall not be deemed to be a waiver of any of the terms or provisions of the Lease or such guaranty, and
Landlord or Tenant, as the case may be, shall have the right thereafter to insist upon strict performance by the other of any and all of them. 

33.2 Holding Over. Tenant shall pay Landlord for each day Tenant retains possession of the Premises or part of them after termination
of this Lease by lapse of time or otherwise at the rate (“Holdover Rate”) which shall be One Hundred Fifty Percent (150%) of the greater of (a) the amount of the Monthly Base Rent for the last period prior to the date of
such termination plus Tenant’s Proportionate Share of Operating Costs, Real Estate Taxes and Insurance; and (b) the then market rental value of the Premises as reasonably determined by Landlord assuming a new lease of the Premises of the
then usual duration and other terms, in either case, prorated on a daily basis, and also pay all damages sustained by Landlord by reason of such retention. Such holding over shall constitute a tenancy at sufferance at the Holdover Rate. In any
event, no provision of this Section 33.2 shall be deemed to waive Landlord’s right of reentry or any other right under this Lease or at law. Additionally, in the event that upon termination of the Lease, Tenant has not fulfilled its
obligation with respect to repairs and cleanup of the Premises or any other surrender obligations of Tenant as set forth in this Lease, then Landlord shall have the right to perform any such obligations at Tenant’s sole cost and expense, and if
such failure is of a nature which actually prevents Landlord from re-letting the space or preparing the space for use or occupancy by a party to whom the Premises have been leased, then any time required by

  
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Landlord to complete such obligations shall be considered a period of holding over and the terms of this Section shall apply. In connection with any such work performed by Landlord, Landlord
shall endeavor in good faith to complete the same as soon as reasonably practical. If Tenant disputes in good faith Landlord’s assertion that it is entitled to hold-over rent because Tenant has failed to surrender the Premises in the condition
required by this Lease, then, prior to the filing of a lawsuit or the initiation of another form of dispute resolution proceeding (and as a condition thereto), the parties shall submit such dispute over the condition of the Premises
(“Claim”), to non-binding mediation (“Mediation”) conducted by a retired judge or other mediator who is a member of JAMS, or any substantially equivalent organization if JAMS is unable or unwilling to perform such
services. Either party may initiate the Mediation by written notice to the other. The date such notice is given is called the “Mediation Initiation Date.” The mediator (“Mediator”) shall be a retired judge or other
mediator affiliated with JAMS, selected either by mutual agreement of the parties involved with the Claim, or if they cannot so agree within twenty (20) calendar days after the Mediation Initiation Date, by the Chief Judicial Officer of JAMS or
through such other procedures as JAMS regularly follows. If the parties mutually agree, a Mediator other than a member of JAMS may be selected in place of a JAMS Mediator. The Mediation shall be held in San Francisco, California, or such other
location as the parties may agree, within twenty (20) calendar days after the Mediator is selected, or such longer period as the parties involved with the Claim and the Mediator mutually decide. The parties shall seek in good faith to resolve
the Claim in the Mediation, and a party’s failure to do so shall (i) be a bar to such party’s collection of attorney’s fees in any subsequent legal proceeding regarding the Claim, and (ii) make such party responsible for any
and all fees incurred by the other party in connection with such Mediation. 
 33.3 Binding Effect. The covenants and conditions
herein contained shall, subject to the provisions as to assignment, apply to and bind the heirs, successors, executors, administrators and assigns of all of the parties hereto; and all of the parties hereto shall be jointly and severally liable
hereunder. 
 33.4 Time of the Essence. Time is of the essence of this Lease with respect to each and every Article, Section and
subsection hereof. 
 33.5 Release of Landlord. If, during the term of this Lease, Landlord shall sell its interest in the Building
or Complex of which the Premises form a part, or the Premises, then from and after the effective date of the sale or conveyance, Landlord shall be released and discharged from any and all obligations and responsibilities under this Lease, except
those already accrued. 
 33.6 Rules and Regulations. Landlord or such other person(s) as Landlord may appoint shall have the
exclusive control and management of the Common Areas and Building and shall have the right, from time to time, to establish, modify, amend and enforce reasonable rules and regulations with respect thereto. Tenant agrees to abide by and conform to
all such rules and regulations, and to cause its employees, suppliers, shippers, customers, and invitees to so abide and conform. Landlord shall not be responsible to Tenant for the non-compliance with said rules and regulations by other tenants of
the Building or Complex. In the event of any conflict between the Rules and Regulations in effect from time to time, the rest of the terms of this Lease, the latter shall prevail. 

  
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 33.7 Transfer to Purchaser. If any security be given by Tenant to secure the faithful
performance of all or any of the covenants of this Lease on the part of Tenant, Landlord may transfer and/or deliver the security, as such, to the purchaser of the reversion, in the event that the reversion be sold, and thereupon Landlord shall be
discharged from any further liability in reference thereto. 
 33.8 Late Charges. Tenant acknowledges that late payment by Tenant to
Landlord of rent or any other payment due hereunder will cause Landlord to incur costs not contemplated by this Lease, the exact amount of such costs being extremely difficult and impractical to fix. Such costs include, without limitation,
processing and accounting charges, and late charges that may be imposed on Landlord by the terms of any encumbrance and note secured by any encumbrance covering the Premises. Therefore, if any installment of rent, or any other payment due hereunder
from Tenant is not received by Landlord when due, Tenant shall pay to Landlord an additional sum of five percent (5%) of such rent or other charge as a late charge. The parties agree that this late charge represents a fair and reasonable
estimate of the cost that Landlord will incur by reason of late payment by Tenant. Acceptance of any late charge shall not constitute a waiver of Tenant default with respect to the overdue amount, or prevent Landlord from exercising any other rights
or remedies available to Landlord. 
 33.9 Interest. Any amount owed by Tenant to Landlord which is not paid within ten
(10) days when due shall bear interest at the lesser of ten percent (10%) per annum or the maximum rate of interest permitted to be contracted for by law. However, interest shall not be payable on late charges to be paid by Tenant under
this Lease. The payment of interest on such amounts shall not excuse or cure any default by Tenant under this Lease. 
 33.10
Authorization to Execute. If Tenant is a corporation, limited liability company, partnership or other entity, Tenant represents and warrants that each individual executing this Lease on behalf of said organization is duly authorized to
execute and deliver this Lease on behalf of said organization in accordance with a duly adopted resolution or other applicable authorization of said organization, and that this Lease is binding upon said organization in accordance with its terms.
Further, if requested by Landlord, Tenant shall, within thirty (30) days after such request, deliver to Landlord a certified copy of a resolution or other applicable authorization of said organization authorizing or ratifying the execution of
this Lease. 
 33.11 Captions. The captions of this Lease are for convenience only and are not a part of this Lease and do not in any
way limit or amplify the terms and provisions of this Lease. 
 33.12 Number and Gender. Whenever the singular number is used in this
Lease and when required by the context, the same shall include the plural, the plural shall include the singular, and the masculine gender shall include the feminine and neuter genders, and the word “person” shall include
corporation, firm or association. If there be more than one Tenant, the obligations imposed under this Lease upon Tenant shall be joint and several. 

33.13 Modifications. This instrument contains all of the agreements, conditions and representations made between the parties to this
Lease and may not be modified orally or in any other manner than by an agreement in writing signed by all of the parties to this Lease. 

  
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 33.14 Payments. Except as otherwise expressly stated, each payment required to be made by
Tenant shall be in addition to and not in substitution for other payments to be made by Tenant. 
 33.15 Severability. The invalidity
of any provision of this Lease, as determined by a court of competent jurisdiction, shall in no way affect the validity of any other provision hereof. 

33.16 No Offer. The preparation and submission of a draft of this Lease by either party to the other shall not constitute an offer, nor
shall either party be bound to any terms of this Lease or the entirety of the Lease itself until both parties have fully executed a final document and an original signature document has been received by both parties. Until such time as described in
the previous sentence, either party is free to terminate negotiations with no obligation to the other. 
 33.17 Light, Air and View.
No diminution of light, air, or view by any structure which may hereafter be erected (whether or not by Landlord) shall entitle Tenant to any reduction of Rent, result in any liability of Landlord to Tenant, or in any other way affect this Lease or
Tenant’s obligations hereunder. 
 33.18 Public Transportation Information. Tenant shall establish and maintain during the Term
hereof a program to encourage maximum use of public transportation by personnel of Tenant employed on the Premises, including without limitation the distribution to such employees of written materials explaining the convenience and availability of
public transportation facilities adjacent or proximate to the Complex, staggering working hours of employees, and encouraging use of such facilities, all at Tenant’s sole reasonable cost and expense. Tenant shall comply with all requirements of
any local transportation management ordinance. 
 33.19 Joint and Several Liability. Should Tenant consist of more than one person or
entity, they shall be jointly and severally liable on this Lease. 
 33.20 Survival of Obligations. All obligations of Tenant which
may accrue or arise during the term of this Lease or as a result of any act or omission of Tenant during said term shall, to the extent they have not been fully performed, satisfied or discharged, survive the expiration or termination of this Lease.

 33.21 Real Estate Brokers. Landlord and Tenant each represents and warrants to the other party that it has not authorized,
retained or employed, or acted by implication to authorize, retain or employ, any real estate broker or salesman to act for it or on its behalf in connection with this Lease so as to cause the other party to be responsible for the payment of a
brokerage commission, except for the Broker(s) identified in Article 1. Landlord and Tenant shall each indemnify, defend and hold the other party harmless from and against any and all claims by any real estate broker or salesman (other than the
Brokers) whom the indemnifying party authorized, retained or employed, or acted by implication to authorize, retain or employ, to act for the indemnifying party in connection with this Lease. Provided that this Lease is fully executed by the parties
hereto, Landlord shall pay a commission to the Brokers subject and pursuant to a separate written agreement between Landlord and such Brokers. 

  
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 33.22 Waiver of California Code Sections. In this Lease, numerous provisions have been
negotiated by the parties, some of which provisions are covered by statute. Whenever a provision of this Lease and a provision of any statute or other law cover the same matter, the provisions of this Lease shall control. Therefore, Tenant waives
(for itself and all persons claiming under Tenant) the provisions of Civil Code Sections 1932(2) and 1933(4) with respect to the destruction of the Premises; Civil Code Sections 1941 and 1942 with respect to Landlord’s repair duties and
Tenant’s right to repair; Code of Civil Procedure Section 1265.130, allowing either party to petition the Superior Court to terminate this Lease in the event of a partial taking of the Premises by condemnation as herein defined; and any
right of redemption or reinstatement of Tenant under any present or future case law or statutory provision (including Code of Civil Procedure Sections 473 and 1179 and Civil Code Section 3275) in the event Tenant is dispossessed from the
Premises for any reason. This waiver applies to future statutes enacted in addition to or in substitution for the statutes specified herein. 

33.23 Quiet Enjoyment. So long as Tenant pays all of the Monthly Base Rent, all additional rent and other sums and charges under the
Lease and otherwise performs all of its obligations in the Lease, Tenant shall have the right to possession and quiet enjoyment of the Premises free from any unreasonable disturbance or interference, subject to the terms and provisions of the Lease.
Landlord represents and warrants that it has the full right and power to execute and perform this Lease and to grant the estate demised herein. 

33.24 Representation. Neither Tenant nor any of its constituent partners, managers, members or shareholders, nor any beneficial owner
of Tenant or of any such partner, manager, member or shareholder (a) is listed on the Specially Designated Nationals and Blocked Persons List maintained by the Office of Foreign Asset Control, Department of the Treasury
(“OFAC”) pursuant to the Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) (“Order”); (b) is listed on any other list of terrorists or terrorist organizations maintained pursuant to the Order,
the rules and regulations of OFAC or any other applicable requirements contained in any enabling legislation or other Executive Orders in respect of the Order (the Order and such other rules, regulations, legislation or orders are collectively
called the “Orders”); (c) is engaged in activities prohibited in the Orders; or (d) has been convicted, pleaded nolo contendere, indicted, arraigned or custodially detained on charges involving money laundering or
predicate crimes to money laundering. 
 33.25 Counterparts. This Lease may be executed in one or more counterparts, including any
facsimile or other electronic version of same, each of which shall be deemed an original, but all of which when taken together shall constitute one agreement. Any facsimile or other electronic signature shall constitute a valid and binding method
for executing this Lease. Executed counterparts of this Lease exchanged by facsimile transmission or other electronic means shall be fully enforceable. 

[the balance of this page has been intentionally left blank; signature page follows] 

  
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 IN WITNESS WHEREOF, Landlord and Tenant have
executed this Lease as of the day and year first written above. 
  

					
	LANDLORD:  		 DWF III GATEWAY, LLC,

a Delaware limited liability company

			
			By:		 Divco West Real Estate Services, Inc.,

a Delaware corporation,
 its Agent

			
			By:		 /s/ James Teng

			Name:  		James Teng
			Its:		Managing Director
		
	TENANT:		 BIOTIE THERAPIES, INC.,

a Delaware corporation

			
			By:		 /s/ Ian J. Massey

			Name:		Ian J. Massey
			Its:		President & COO

  
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 EXHIBIT A 

FLOOR PLAN OF PREMISES 

Exhibit A is intended only to show the general layout of the Premises as of the beginning of the Term of this Lease. The depiction of interior
windows, cubicles, modules, furniture and equipment in this Exhibit is for illustrative purposes only, but does not mean that such items exist. Landlord is not required to provide, install or construct any such items. It is not to be scaled; any
measurements or distances shown should be taken as approximate. The inclusion of elevators, stairways electrical and mechanical closets, and other similar facilities for the benefit of occupants of the Building does not mean such items are part of
the Premises. 
  
 

 

  
 A–1 

 EXHIBIT B 

WORK LETTER 

1. Defined Terms. All defined terms referred to in this Exhibit shall have the same meaning as defined in that certain Lease by and
between DWF III GATEWAY, LLC, a Delaware limited liability company, as Landlord, and BIOTIE THERAPIES, INC., a Delaware corporation, as Tenant (the “Lease”) to which this
Exhibit is a part, except where expressly defined to the contrary. 
 2. Construction of the Tenant Improvements. Landlord shall
construct the Tenant Improvements in accordance with this exhibit and the construction contract to be executed by Landlord and its contractor(s). The construction contract for constructing the Tenant Improvements and the contractor(s) to perform the
work shall be approved and/or selected, as the case may be, by Landlord at its reasonable discretion after consultation with, but without the consent of Tenant. 

3. Additional Definitions. Each of the following terms shall have the following meaning: 

“Construction Budget”- An estimate of the Construction Costs for the Tenant Improvements prepared by Landlord after or in
connection with the preparation of the Construction Plans. 
 “Construction Costs”- All costs and expenses approved by
Landlord to construct the Tenant Improvements, including all fees and expenses for: 
 (a) architectural/space planning services utilized
by Landlord in the preparation of any space plan; 
 (b) architects, engineers and consultants in the preparation of the Preliminary Plans,
Construction Plans, including mechanical, electrical, plumbing and structural drawings and of all other aspects of the Construction Plans, and for processing governmental applications and applications for payment, observing construction of the work,
and other customary engineering, architectural, interior design and space planning services; 
 (c) surveys, reports, environmental and
other tests and investigations of the site and any improvements thereon; 
 (d) labor, materials, equipment and fixtures supplied by the
general contractor, its subcontractors and/or materialmen; 
 (e) the furnishing and installation of all heating, ventilation and air
conditioning duct work, terminal boxes, distributing defusers and accessories required for completing the heating, ventilation and air-conditioning system in the Premises, including costs of meter and key control for after-hour usage, if required by
Landlord; 

  
 B–1 

 (f) all electrical circuits, wiring, lighting fixtures, and tube outlets furnished and installed
throughout the Premises, including costs of meter and key control for after-hour electrical power usage; 
 (g) all window and floor
coverings in the Premises; 
 (h) all fire and life safety control systems , such as fire walls, sprinklers and fire alarms, including
piping, wiring and accessories installed within the Premises; 
 (i) all plumbing, fixtures, pipes and accessories installed within the
Premises; 
 (j) fees charged by the city and/or county where the Building is located (including, without limitation, fees for building
permits and plan checks) required for the Tenant improvement work in the Premises; 
 (k) supervision and administration expense, including
the construction supervision fee payable to Landlord’s agent and property manager and/or representative equal to four percent (4%) of the Construction Costs; 

(l) all taxes, fees, charges and levies by governmental and quasi-governmental agencies for
authorization, approvals, licenses and permits; and all sales, use and excise taxes for the materials supplied and services rendered in connection with the installation and construction of the Tenant Improvements; and 

(m) all costs and expenses incurred to comply with all laws, rules, regulations or ordinances of any governmental authority for any work at
the Building or Complex in order to construct the Tenant Improvements. 
 The term Construction Costs shall not include any fees, costs,
expenses, compensation or other consideration payable to Tenant, or any of its officers, directors, employees or affiliates, or the cost of any of Tenant’s furniture, artifacts, trade fixtures, telephone and computer systems and related
facilities, or equipment. 
 “Construction Plans” - The complete plans and specifications for the construction of the
Tenant Improvements consisting of all architectural, engineering, mechanical and electrical drawings and specifications which are required to obtain all building permits, licenses and certificates from the applicable governmental authority(ies) for
the construction of the Tenant Improvements. The Construction Plans shall be prepared by duly licensed and/or registered architectural and/or engineering professionals selected by Landlord in its reasonable discretion, and in all respects shall be
in substantial compliance with all applicable laws, rules, regulations, building codes for the city and county where the Building is located. 

“Force Majeure Delays” - Any delay, other than a Tenant Delay, by Landlord in completing the Tenant Improvements by the
Estimated Commencement Date set forth in the Lease by reason of (i) any strike, lockout or other labor trouble or industrial disturbance (whether 

  
 B–2 

 
or not on the part of the employees of either party hereto), (ii) governmental preemption of priorities or other controls in connection with a national or other public emergency, civil
disturbance, riot, war, sabotage, blockade, embargo, inability to secure customary materials, supplies or labor through ordinary sources by reason of regulation or order of any government or regulatory body, or (iii) shortages of fuel,
materials, supplies or labor, (iv) lightning, earthquake, fire, storm, tornado, flood, washout explosion, inclement weather or any other similar industry-wide or Building-wide cause beyond the reasonable control of Landlord, or (v) any
other cause, whether similar or dissimilar to the above, beyond Landlord’s reasonable control. The time for performance of any obligation of Landlord to construct Landlord’s Work under this Work Letter or the Lease shall be extended at
Landlord’s election by the period of any delay caused by any of the foregoing events. 
 “Landlord’s Allowance” -
The amount of $602,840.00 (i.e., $40.00 for each rentable square foot of the Premises) to be paid by Landlord for the Construction Costs for the Tenant Improvements, which sum shall be paid directly to the contracting parties entitled to
payment. Any unused portion of Landlord’s Allowance for the Tenant Improvements shall remain the property of Landlord, and Tenant shall have no interest in said funds. Notwithstanding the foregoing, following completion of the Tenant
Improvements, in the event a portion of Landlord’s Allowance remains unused, then up to $60,284.00 (i.e., 10% of Landlord’s Allowance) may be utilized by Tenant as an offset against future Monthly Base Rent becoming due; provided,
however that any additional unused portion shall be forfeited by Tenant and retained by Landlord. 
 “Substantial Completion,”
“Substantially Complete,” “Substantially Completed” - The terms Substantial Completion, Substantially Completed and Substantially Complete shall mean when the following have occurred or would have occurred but for Tenant
Delays: 
 (a) Landlord has delivered to Tenant a written notice accurately stating that the Tenant Improvements have been Substantially
Completed substantially in accordance with the Construction Plans, except “punch list” items which may be completed without materially impairing Tenant’s use of the Premises or a material portion thereof; and 

(b) Landlord has obtained from the appropriate governmental authority a temporary, conditional or final certificate of occupancy or signed
building permit (or equivalent), if one is required, for the Tenant Improvements permitting occupancy of the Premises by Tenant. 

“Supplemental Allowance”- The amount of $150,710.00 (i.e., $10.00 for each rentable square foot of the Premises) which
may be utilized by Tenant for the Construction Costs for the Tenant Improvements and any changes in the Tenant Improvements that are requested by Tenant pursuant to Section 8 below. In the event Tenant utilizes any portion of the Supplemental
Allowance, Tenant shall repay the same to Landlord, as additional Monthly Base Rent, in substantially equal self-amortizing installments over the initial sixty (60) month Term of the Lease, together with interest on the balance outstanding from
time to time at the rate of eight percent (8.0%) per annum. Promptly following the completion of the Tenant Improvements and the determination of the total amount of the Supplemental Allowance utilized by Tenant,

  
 B–3 

 
Landlord and Tenant shall acknowledge the amortization payment in the Acknowledgement of Commencement Date Memorandum. 

“Space Plan”- That certain Space Plan prepared by RMW Architecture and Interiors, dated 8-14-13, as Project - Biotie Floor 3
Space Plan and attached hereto as Exhibit B-1. Landlord shall be entitled to rely upon all plans, drawings and information supplied by or for Tenant in preparing the Space Plan. Tenant hereby approves of the Space Plan. The depiction
of cubicles, modules, interior windows, furniture and equipment in Exhibit B-1 is for illustrative purposes only, but does not mean that such items exist. Landlord is not required to provide, install or construct any such items. 

“Tenant Delay” - Any delay incurred by Landlord in the completion of the Tenant Improvements due to (i) a delay by
Tenant, or by any person employed or engaged by Tenant, in approving or delivering to Landlord any plans, schedules or information, including, without limitation, the Preliminary Plans and the Construction Plans beyond the applicable time period set
forth in this Exhibit, if any; (ii) a delay in the performance of work in the Premises by Tenant or any person employed by Tenant; (iii) any changes requested by Tenant in or to previously approved work or in previously approved
Construction Plans; (iv) requests by Tenant for non-Building standard materials and/or finishes which are not readily available, and/or delays in delivery of any materials specified by Tenant through change orders, provided Landlord notifies
Tenant in writing within three (3) days of Tenant’s selection of such items that a Tenant Delay could result; (v) the failure of Tenant to pay as and when due under this Exhibit all Construction Costs and other costs and expenses to
construct the Tenant Improvements in excess of Landlord’s Allowance; or (vi) interference by Tenant or any of Tenant’s agents, employees, vendors or contractors with the construction of the Tenant Improvements. 

“Tenant Improvements” - The improvements to be installed by Landlord in the Premises substantially in accordance with the
Construction Plans approved by Tenant and Landlord. 
 4. Preparation of Preliminary Plans and Construction Plans. 

4.1 Preliminary Plans. Landlord confirms that concurrent with its execution of the Lease, Tenant has submitted to Landlord or its
architect or designer all additional information, including occupancy requirements for the Tenant Improvements in the Premises (“Information”), necessary to enable the architect, designer or contractor to prepare preliminary plans
for the Tenant Improvements containing all demising walls, corridors, entrances, exits, doors, interior partitions, and the locations of all offices, conference rooms, computer rooms, and other rooms and layout. The preliminary plans shall be
consistent with the Space Plan. Landlord shall be entitled to rely upon all plans, drawings and information supplied by or for Tenant in preparing the preliminary plans. Within five business (5) days after receipt of the preliminary plans,
Tenant shall notify Landlord in writing that (i) Tenant approved such preliminary plans; or (ii) Tenant disapproves such preliminary plans in the particular instances specified by Tenant in such notice (including, without limitation, the
specific changes requested by Tenant), but such disapproval shall constitute a Tenant Delay unless the preliminary plans are inconsistent with the Information. Tenant shall not unreasonably withhold its approval to the preliminary plans. The

  
 B–4 

 
failure of Tenant to provide such written notice within said five (5) business day period shall be deemed as approval by Tenant of such preliminary plans. The preliminary plans approved by
the parties as provided above shall be referred to as the “Preliminary Plans.” 
 4.2 Construction Plans. After
approval of the Preliminary Plans, Landlord shall cause to be prepared Construction Plans for the construction of the Tenant Improvements and deliver the same to Tenant as soon as reasonably possible. Within five (5) business days after receipt
of the Construction Plans, Tenant shall notify Landlord in writing that (i) Tenant approved the Construction Plans; or (ii) Tenant disapproves the Construction Plans because they vary in design from the Preliminary Plans approved by
Landlord and Tenant in the particular instances specified by Tenant in such notice (including, without limitation, the specific changes requested by Tenant), but such disapproval shall constitute a Tenant Delay unless the Construction Plans are
inconsistent with the preliminary plans. The failure of Tenant to provide such written notice within said five (5) business day period shall be deemed as approval by Tenant of such plans. 

5. Approval of the Construction Budget. After approval of the Construction Plans by Landlord and Tenant as provided above, Landlord
shall prepare the Construction Budget for the Construction Costs. The Construction Budget shall not be subject to the prior written approval of Tenant, unless the estimated Construction Costs exceed the amount of Landlord’s Allowance. If the
Construction Budget reflects Construction Costs in excess of Landlord’s Allowance, Landlord shall deliver a copy of such Construction Budget to Tenant for its review and approval, which shall not be unreasonably withheld. Tenant shall notify
Landlord in writing within five (5) business days after receipt of the Construction Budget that (a) Tenant approves the Construction Budget, or (b) that Tenant disapproves of the Construction Budget because it varies from the
Construction Plans or contains specific costs not contained within the meaning of Construction Costs. Such disapproval shall constitute a Tenant Delay unless the Construction Budget varies from the Construction Plans or contains specific costs not
contained within the meaning of Construction Costs. The failure of Tenant to provide such written notice within said five (5) business day period shall be deemed an approval by Tenant. 

6. Building Permits. After approval by Landlord and Tenant of the Construction Plans and Construction Budget as provided above,
Landlord or its contractor shall submit the Construction Plans to the appropriate governmental body for plan checking and a building permit. Landlord, with Tenant’s cooperation, shall cause to be made any change in the Construction Plans
necessary to obtain the building permit and to the extent the aggregate amount of the Construction Costs exceeds the amount of Landlord’s Allowance and, if utilized by Tenant, the Supplemental Allowance, Tenant shall be responsible for such
additional costs, notwithstanding the amount previously specified in the Construction Budget approved by Landlord and Tenant. 
 7.
Payment. Landlord shall pay for the Construction Costs for the Tenant Improvements, not to exceed the amount of Landlord’s Allowance and any portion of the Supplemental Allowance utilized by Tenant. Tenant acknowledges and agrees that it
shall be responsible for payment of all Construction Costs in excess of Landlord’s Allowance (plus any portion of the Supplemental Allowance utilized by Tenant for the Construction Costs), provided

  
 B–5 

 
such excess is shown on the Construction Budget approved by Tenant or such excess is the result of any Changes as provided in Section 8 below. Tenant shall pay to Landlord within ten
(10) days after request from Landlord the amount of such excess Construction Costs. 
 8. Changes. Any changes in the
Construction Plans or Construction Budget, including, without limitation, any changes required by any applicable law, rule, regulation or ordinance, shall require the prior written consent of Landlord in its reasonable discretion. Any changes
requested by Tenant and approved by Landlord following Tenant’s approval of the Construction Plans and Construction Budget shall be prepared by Landlord’s architect, engineer or contractor. The cost of such changes, including the cost to
revise the Construction Plans, obtain any additional permits and construct any additional improvements required as a result thereof, and the cost for materials and labor, and all other additional costs incurred by Landlord from resulting delays in
completing the Tenant Improvements, shall be paid out of Landlord’s Allowance and any portion of the Supplemental Allowance utilized by Tenant for such purpose (only to the extent funds are available and not committed for payment of other
Construction Costs). If such costs for changes exceed the Landlord’s Allowance (and any portion of the Supplemental Allowance utilized by Tenant for such purpose), such excess costs shall be paid by Tenant, at its sole cost and expense, to
Landlord within ten (10) days after Tenant’s receipt of notice from Landlord. If Landlord does not receive such payment within said ten (10) day period, Landlord shall have the right, in addition to any other rights or remedies
available under the Lease, at law or in equity, to (i) discontinue all or any portion of the work until it receives said payment; (ii) proceed with the other work not affected by such change until such payment is received;
(iii) proceed with the work contemplated with such change; or (iv) proceed with the work without making such change; in which case the commencement or completion of such work shall not be deemed a waiver of Tenant’s obligation to pay
for same or any additional costs or expenses incurred as a result thereof. Any delay in Substantial Completion beyond November 1, 2013 caused as a result of such a change or request for a change shall constitute a Tenant Delay. 

9. Tenant’s Representative. Tenant hereby authorizes Zack McNealy, located at 601 Gateway Blvd., Suite 1200, South San Francisco,
CA 94080, 650- 244-4859, zack.mcnealy@biotie.com, as Tenant’s representative, to act on its behalf and represents its interests with respect to the construction of Tenant Improvements, and to make decisions binding upon Tenant with
respect to such matters. 
 10. Tenant’s Lease Default. Notwithstanding any provision to the contrary contained in the Lease or
this Exhibit, if an event of default beyond any applicable cure period by Tenant under the Lease, or a default beyond any applicable cure period by Tenant under this Exhibit, has occurred at any time on or before the Substantial Completion of the
Tenant Improvements, then (i) in addition to all other rights and remedies granted to Landlord pursuant to the Lease and/or this Exhibit, Landlord shall have the right to cease the construction of the Tenant Improvements (in which case, Tenant
shall be responsible for any delay in the Substantial Completion of the Tenant Improvements caused by such work stoppage), and (ii) all other obligations of Landlord under the terms of this Exhibit shall be forgiven until such time as such
default is cured pursuant to the terms of the Lease. 

  
 B–6 

 EXHIBIT B-1 

APPROVED SPACE PLAN 

 
 

 

  
 B–7 

 EXHIBIT C 

ACKNOWLEDGEMENT OF COMMENCEMENT DATE 

This Acknowledgement of Commencement Date is dated as of             ,
20     between DWF III GATEWAY, LLC, a Delaware limited liability company (“Landlord”), and BIOTIE THERAPIES, INC., a Delaware corporation
(“Tenant”), who entered into a lease dated for reference purposes as of August 20, 2013 covering certain premises located in Suites 350 and 370 of the building at 701 Gateway Boulevard, South San Francisco, California. All
capitalized terms, if not defined herein, shall be defined as they are defined in the Lease. 
 1. The parties to this document hereby agree
that the date of             , 20     is the “Commencement Date” of the Term. 

2. Tenant hereby confirms the following: 

(a) That it has accepted possession of Premises pursuant to the terms of the Lease; and 

(b) That the Tenant Improvements required to be furnished according to the Lease by Landlord in the Premises have been Substantially
Completed. 
 3. [If Applicable: Tenant hereby acknowledges that Landlord has provided a Supplemental Allowance to Tenant in
the amount of          Dollars ($        ), and, pursuant to Section 3 of Exhibit C to the Lease, such amount shall be repayable by Tenant in additional monthly
installments of Monthly Base Rent of          Dollars ($        ) each. Accordingly, the Monthly Base Rent table set forth in Section 1.9 of the Lease is
hereby revised as follows: Insert revised Table] 
 4. This agreement, each and all of the provisions hereof, shall inure to
the benefit, or bind, as the case may require, the parties hereto, and their respective heirs, successors, and assigns subject to the restrictions upon assignment and subletting contained in the Lease. 

5. Each party represents and warrants to the other that it is duly authorized to enter into this Amendment and perform its obligations without
the consent or approval of any other party and that the person signing on its behalf is duly authorized to sign on behalf of such party. 

6. This document may be executed in one or more counterparts, including any facsimile or other electronic version of same, each of which shall
be deemed an original, but all of which when taken together shall constitute one agreement. Any facsimile or other electronic signature shall constitute a valid and binding method for executing this document. Executed counterparts of this document
exchanged by facsimile transmission or other electronic means shall be fully enforceable. 

  
 C–1 

							
	LANDLORD:  		 DWF III GATEWAY, LLC,

a Delaware limited liability company

			
			By:		 Divco West Real Estate Services, Inc.,

a Delaware corporation,
 its Agent

				
					By:		  

					Name:  		  

					Its:		  

		
	TENANT:		 BIOTIE THERAPIES, INC.,

a Delaware corporation

			
			By:		  

			Name:  		  

			Its:		  

  
 C–2 

 EXHIBIT D 

RULES AND REGULATIONS 

All capitalized terms referred to in this Exhibit shall have the same meaning provided in the Office Lease to which this Exhibit is attached,
except where expressly provided to the contrary in this Exhibit D. 
 1. No sidewalks, entrance, passages, courts, elevators, vestibules,
stairways, corridors or halls shall be obstructed or encumbered by Tenant or used for any purpose other than ingress and egress to and from the Premises and if the Premises are situated on the ground floor of the Building, Tenant shall further, at
Tenant’s own expense, keep the sidewalks and curb directly in front of the Premises clean and free from rubbish. 
 2. No awning or
other projection shall be attached to the outside walls or windows of the Building or Complex without the prior written consent of Landlord in its sole and absolute discretion. No curtains, blinds, shades, drapes or screens shall be attached to or
hung in, or used in connection with any window or door of the Premises, without the prior written consent of Landlord in its sole and absolute discretion. Such awnings, curtains, blinds, shades, drapes, screens and other fixtures must be of a
quality, type, design, color, material and general appearance approved by Landlord, and shall be attached in the manner approved by Landlord in its sole and absolute discretion. All lighting fixtures hung in offices or spaces along the perimeter of
the Premises must be of a quality, type, design, bulb color, size and general appearance approved by Landlord. 
 3. No sign, advertisement,
notice, lettering, decoration or other thing shall be exhibited, inscribed, painted or affixed by Tenant on any part of the outside or inside of the Premises or of the Building, without the prior written consent of Landlord in its sole and absolute
discretion. In the event of the violation of the foregoing by Tenant, Landlord may remove same without any liability, and may charge the expense incurred by such removal to Tenant. 

4. The sashes, sash doors, skylights, windows and doors that reflect or admit light or air into the halls, passageways or other public places
in the Building or Complex shall not be covered or obstructed by Tenant, nor shall any bottles, parcels or other articles be placed on the window sills or in the public portions of the Building or Complex. 

5. No show cases or other articles shall be put in front of or affixed to any part of the exterior of the Building or Complex, nor placed in
public portions thereof without the prior written consent of Landlord. 
 6. The restrooms, toilets, wash bowls, and other apparatus shall
not be used for any purpose other than that for which they were constructed, and no sweepings, rubbish, rags or other foreign substance of any kind shall be thrown into them. The expense of any breakage, stoppage, or damage resulting from violation
of this rule shall be borne by the tenant who caused, or whose agents, servants, employees, contractors, visitors or licensees caused, the breakage, stoppage, or damage. 

  
 D–1 

 7. Tenant shall not mark, paint, drill into or in any way deface any part of the Premises or the
Building or Complex. No boring, cutting or stringing of wires shall be permitted, except with the prior written consent of Landlord, and as Landlord may direct, in its reasonable discretion. 

8. No animal or bird or bicycle or vehicle of any kind shall be brought into or kept in or about the Premises, Building or Complex, except
seeing-eye dogs or other seeing-eye animals or other animals or equipment required by any disabled employee or invitee of Tenant. 
 9.
Prior to leaving the Premises for the day, Tenant shall draw or lower window coverings and extinguish all lights. Tenant shall assume all responsibility, including keeping doors locked and other means of entry to the Premises closed, for protecting
the Premises from theft, robbery, and pilferage. 
 10. Tenant shall not make, or permit to be made, any unseemly or disturbing noises or
disturb or interfere with any occupant of the Building or Complex, or neighboring buildings or premises, or those having business with them. Tenant shall not harass or annoy any occupant of the Building or Complex, including, without limitation, any
act or conduct that may violate, breach or infringe upon any federal, state or local laws or civil rights, including those pertaining to the protection of the civil rights of any person based on sex, race, religion, sexual preference, age or other
consideration. Tenant shall not throw anything out of the doors, windows or skylights or down the passageways. 
 11. Neither Tenant nor any
of Tenant’s agents, servants, employees, contractors, visitors or licensees shall at any time bring or keep upon the Premises, Building or Complex any flammable, combustible or explosive fluid, chemical or substance. 

12. Except with the prior written consent of Landlord, no additional locks, bolts or mail slots of any kind shall be placed upon any of the
doors or windows by Tenant, nor shall any change be made in existing locks or the mechanism thereof. Tenant must, upon the termination of the tenancy, restore to Landlord all keys of stores, offices and toilet rooms, either furnished to, or
otherwise procured by Tenant, and in the event of the loss of any keys so furnished, Tenant shall pay to Landlord the reasonable cost thereof. 

Two keys will be furnished by Landlord for the Premises, and any additional keys required by Tenant must be obtained from Landlord at a
reasonable cost to be established by Landlord. 
 If there is a card key or other form of keyless entry to the Building, Landlord shall
provide Tenant as of the commencement of the Term of its lease with one keyless fobs for each 250 square feet of rentable space in such Tenant’s Premises for access to the Building and elevator. All additional keyless cards or fobs requested by
Tenant and any replacement for any lost or damaged keyless cards or fobs will be provided by Landlord at a cost established by Landlord from time to time for each additional or replaced keyless fob, as cost may be increased by Landlord from time to
time. 
 13. No furniture, freight, or equipment of any kind may be brought into or out of the Building without prior notice to Landlord.
All moving activity into or out of the Building must 

  
 D–2 

 
be scheduled with Landlord and done only at the time and in the manner designated by Landlord. No service deliveries (other than messenger services) shall be allowed between the hours of 7:00
a.m. and 9:00 a.m., 12:00 p.m. and 1:00 p.m., and 4:00 p.m. and 6:00 p.m., Monday through Friday. Landlord may at any time restrict the elevators and areas of the Building into which messengers may enter and may require that deliveries be left
at the lobby security desk for pickup by Tenant. Landlord may prescribe the weight, size, and position of all safes and other heavy property brought into the Building and the times and manner of moving those items within and out of the Building.
Tenant shall not overload the floor of the Premises. If considered necessary by Landlord, safes and other heavy objects must stand on supports that are adequate to distribute the weight properly. Landlord shall not be responsible for loss of or
damage to any safe or property. Any damage to any part of the Building or to its contents, occupants, or visitors caused by moving or maintaining any safe or other property referred to in this clause shall be the sole responsibility and expense of
Tenant. Landlord reserves the right to inspect all safes, freight or other bulky articles to be brought into the Building and to exclude from the Building all safes, freight or other bulky articles which violate any of these Rules and Regulations or
the Lease of which these Rules and Regulations are a part. No packages, supplies, equipment, or merchandise may be received in the Building or carried up or down in the elevators, except between those hours and in that specific elevator that
Landlord shall designate. 
 14. Landlord shall have the right to prohibit any advertising or business conducted by Tenant referring to the
Building which, in Landlord’s good faith opinion, tends to impair the reputation of the Building or its desirability as a first class building for offices and/or commercial services and upon notice from Landlord, Tenant shall refrain from or
discontinue such advertising. 
 15. Landlord reserves the right to exclude from the Building between the hours of 6:00 p.m. and 8:00 a.m.
Monday through Friday, after 1:00 p.m. on Saturdays and at all hours Sundays and legal holidays, all persons who do not present a pass to the Building issued by Landlord. Such hours are subject to change in Landlord’s sole and absolute
discretion upon written from Landlord. Landlord may furnish passes to Tenant so that Tenant may validate and issue same. Tenant shall safeguard said passes and shall be responsible for all acts of persons in or about the Building who possess a pass
issued to Tenant. Landlord reserves the right to exclude or expel from the Building and Complex any person who, in Landlord’s judgment, is under the influence of alcohol or drugs or commits any act in violation of any of these Rules and
Regulations. 
 16. When departing after the Building’s normal business hours, Tenant and Tenant’s employees and agents must be
sure that the doors to the Building are securely closed and locked. Any person, including Tenant and Tenant’s employees and agents, who enters or leaves the Building at any time when it is locked or at any time considered to be after the
Building’s normal business hours, may be required to sign the Building register. Access to the Building may be refused unless the person seeking access has proper identification or has previously arranged a pass for access to the Building.
Landlord and its agents shall not be liable for damages for any error concerning the admission to, or exclusion from, the Building of any person. Landlord reserves the right, in the event of invasion, mob, riot, public excitement, or other
commotion, to prevent access to the Building or Complex during the continuance of that event by any means it considers appropriate for the safety and protection of life and property. 

  
 D–3 

 17. Tenant’s contractors shall, while in the Premises, Building or elsewhere in the Complex,
be subject to and under the control and direction of the Building Manager (but not as agent or servant of said Building Manager or of Landlord). 

18. If the Premises is or becomes infested with vermin as a result of the use or any misuse or neglect of the Premises by Tenant, its agents,
servants, employees, contractors, visitors or licensees, Tenant shall forthwith at Tenant’s expense cause the same to be exterminated from time to time to the satisfaction of Landlord and shall employ such licensed exterminators as shall be
approved in writing in advance by Landlord. 
 19. The requirements of Tenant will be attended to only upon application at the office of the
Building. Building personnel shall not perform any work or do anything outside of their regular duties unless under special instructions from the office of the Landlord. 

20. Tenant and Tenant’s employees, agents, contractors and invitees shall not loiter in or on the entrances, corridors, sidewalks,
lobbies, halls, stairways, elevators, or common areas for the purpose of smoking tobacco products or for any other purpose. Tenant and Tenant’s employees and agents shall not obstruct those areas but use them only as a means of ingress to and
egress from the Premises, Building or Complex. Canvassing, soliciting and peddling in the Building or Common Areas of the Complex are prohibited and Tenant shall cooperate to prevent the same. 

21. No air conditioning unit, system or apparatus shall be installed or used by Tenant without the written consent of Landlord in its sole and
absolute discretion. Tenant shall not waste electricity, water, or air-conditioning and shall cooperate fully with Landlord to ensure the most effective operation of the Building’s heating and air-conditioning system. 

22. There shall not be used in any premises, or in the public halls, plaza areas, lobbies, or elsewhere in the Building or Complex, either by
Tenant or by jobbers or others, in the delivery or receipt of merchandise, any hand trucks or dollies, except those equipped with rubber tires and sideguards. 

23. Tenant, Tenant’s agents, servants, employees, contractors, licensees, or visitors shall not park any vehicles in any driveways,
service entrances, or areas posted “No Parking” and shall comply with any other parking restrictions imposed by Landlord from time to time. 

24. Tenant shall install and maintain, at Tenant’s sole cost and expense, an adequate visibly marked (at all times properly operational)
fire extinguisher next to any duplicating or photocopying machine or similar heat producing equipment, which may or may not contain combustible material, in the Premises, Building or Complex. 

25. Tenant shall keep its window coverings closed during any period of the day when the sun is shining directly on the windows of the
Premises. 
 26. Tenant shall not use the name of the Building for any purpose other than as the address of the business to be conducted by
Tenant in the Premises, nor shall Tenant use any picture of the Building in its advertising, stationery or in any other manner without the prior 

  
 D–4 

 
written permission of Landlord. Landlord expressly reserves the right at any time to change said name without in any manner being liable to Tenant therefor. 

27. Tenant shall not prepare any food nor do any cooking, operate or conduct any restaurant, luncheonette or cafeteria for the sale or service
of food or beverages to its employees or to others, except that food and beverage preparation by Tenant’s employees using microwave ovens or coffee makers shall be permitted; provided, however, no popcorn may be cooked, heated or otherwise
prepared in any microwave oven or any other equipment in the Premises and no odors of cooking or other processes may emanate from the Premises. Tenant shall not install or permit the installation or use of any vending machine or permit the delivery
of any food or beverage to the Premises except by such persons and in such manner as are approved in advance in writing by Landlord. 
 28.
Business machines and mechanical equipment shall be placed and maintained by Tenant at Tenant’s expense in settings sufficient in Landlord’s judgment to absorb and prevent vibration, noise and annoyance. Tenant shall not install any
machine or equipment which causes noise, heat, cold or vibration to be transmitted to the structure of the Building in which the Premises are located without Landlord’s prior written consent in its sole and absolute discretion. Tenant shall not
place a load upon any floor of the Premises exceeding the floor load per square foot which such floor was designed to carry and which is allowed by law. 

29. Smoking is prohibited in the Building, including, without limitation, the main lobby, all hallways, all elevators, all elevator lobbies
and all restrooms. 
 30. Tenant shall store all trash and garbage within the interior of the Premises. Tenant shall not place or have
placed in the trash boxes or receptacles any material that may not or cannot be disposed of in the ordinary and customary manner of removing and disposing of trash in the vicinity of the Building. In disposing of trash and garbage, Tenant shall
comply fully with any law or ordinance governing that disposal. All trash, garbage, and refuse disposal shall be made only through entry-ways and elevators provided for that purpose and shall be made only at times designated by Landlord. 

31. Tenant shall comply with requests by Landlord that Tenant inform Tenant’s employees of items of importance to Landlord. 

32. Tenant may not introduce telephone, cable or other communication or telecommunication wires or other wires into the Premises without first
obtaining Landlord’s approval of the method and location of such introduction. No boring or cutting for telephone wires or other wires shall be allowed without Landlord’s consent. The location of telephones, call boxes, and other office
equipment affixed to the Premises shall be subject to Landlord’s prior approval 
 33. Landlord reserves the right at any time to
change or rescind any one or more of these Rules and Regulations or to make any additional reasonable Rules and Regulations that, in Landlord’s sole and absolute discretion, may be necessary for: 

(a) The management, safety, care, and cleanliness of the Premises, Building or Complex; 

  
 D–5 

 (b) The preservation of good order; or 

(c) The convenience of other occupants and tenants in the Building or Complex. 

Landlord may waive any one or more of these Rules and Regulations for the benefit of any particular tenants. No waiver by Landlord shall be
construed as a waiver of those Rules and Regulations in favor of any other tenant, and no waiver shall prevent Landlord from enforcing those Rules or Regulations against any other tenant of the Building or Complex. In the event of any conflict
between the terms of any Rule or Regulation in effect from time to time and the terms of the Lease to which this Exhibit is attached, the latter shall control. 

[remainder of page intentionally left blank] 

  
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 ADDENDUM NO. 1 

This Addendum No. 1 (this “Addendum”) is made in connection with and is a part of that certain Office Lease, dated as of
August 20, 2013 by and between DWF III Gateway, LLC, a Delaware limited liability company, as Landlord, and BIOTIE THERAPIES, INC., a Delaware corporation, as Tenant, (the “Lease”).

 1. Definitions and Conflict. All capitalized terms referred to in this Addendum shall have the same meaning as provided in the
Lease, except as expressly provided to the contrary in this Addendum. In case of any conflict between any term or provision of the Lease and any exhibits attached thereto and this Addendum, this Addendum shall control. 

2. Option to Extend and Rent During the Extended Period. Tenant shall have one (1) option to extend the Term of the Lease for a
period of five (5) years (the period shall be referred to as the “Extension Period”) by giving written notice of exercise of such option (“Extension Option Notice”) at least two hundred seventy (270) days,
but not more than three hundred sixty-five (365) days, prior to the expiration of the Term. The Extension Period shall commence, if at all, immediately following the expiration of the initial Term of the Lease. If Tenant is in default beyond
any applicable cure period under any term or provision of the Lease on the date of giving an Extension Option Notice, or if Tenant is in default beyond any applicable cure period under any term or provision of the Lease on the date of the applicable
Extension Period is to commence, the Extension Period at the option of Landlord shall not commence and the Lease shall expire at the end of initial Term. The Extension Period shall be upon all of the terms and provisions of the Lease, except that
(i) the Monthly Base Rent during such Extension Period shall be one hundred percent (100%) of then Fair Market Rent, (ii) any work, allowance, free rent, or concession provided by Landlord in connection with the commencement of the
initial Term shall not apply; and (iii) Tenant shall not have any additional option to extend. 
 2.1 Fair Market Rent. The term
“Fair Market Rent” for purposes of determining Monthly Base Rent during the Extension Period shall mean the Monthly Base Rent generally applicable to office leases at first class office buildings of comparable size, age, quality of
the Premises in the South San Francisco, California area projected as of the first day of the Extension Period by giving due consideration for the quality of the Building and improvements therein (including the quality of the then existing
improvements in the Premises as if they had been newly constructed and paid for by Landlord on the first day of the Extension Period specifically for the Extension Period), the quality of the credit of the tenants, for a term comparable to the
Extension Period at the time the commencement of the Extension Period is scheduled to commence, taking into consideration tenant concessions such as free rent and tenant allowances, and otherwise subject to the terms and conditions of this Lease
that will be applicable during the Extension Period. 
 2.2 Procedure to Determine Fair Market Rent. Landlord shall notify Tenant in
writing of Landlord’s determination of the Fair Market Rent (“Landlord’s FMR”) within thirty (30) days after receipt of the Extension Option Notice. Within fifteen (15) days after receipt of such written notice
of Landlord’s FMR, Tenant shall have the right either to: (i) accept Landlord’s FMR, or (ii) elect to have the Fair Market Rent determined in accordance with the 

  
 1 

 
appraisal procedure set forth below. The failure of Tenant to provide written notice of its election under the preceding sentence shall be deemed Tenant’s election to have the Fair Market
Rent determined in accordance with the appraisal procedure set forth below. The election (or deemed election) by Tenant under this section shall be non-revocable and binding on the parties. 

2.3 Appraisers. If Tenant has elected (or is deemed to have elected) to have the Fair Market Rent determined by an appraisal, then
within ten (10) days after receipt of Tenant’s written notice of such an election (or the date of Tenant’s deemed election), each party, by giving written notice to the other party, shall appoint a broker to render a written opinion
of the Fair Market Rent for the Extension Period. Each broker must be a real estate broker licensed in the State where the Building is located for at least five years and with at least five years experience in the appraisal of rental rates of leases
or in the leasing of space in office buildings in South San Francisco and otherwise unaffiliated with either Landlord or Tenant. The two brokers shall render their written opinions of the Fair Market Rent for the Extension Period to Landlord and
Tenant within thirty (30) days after the appointment of the second broker. If the opinions of the Fair Market Rent of the brokers are within three percent (3%) of each other, then the average of the two appraisals of Fair Market Rent shall
be the Fair Market Rent for the Extension Period. If one party does not appoint its broker as provided above, then the one appointed shall determine the Fair Market Rent. The Fair Market Rent so determined under this section shall be binding on
Landlord and Tenant. 
 2.4 Third Appraiser. If the opinions of the Fair Market Rent determined by the brokers are more than three
percent (3%) apart, then the two brokers shall pick a third broker within ten (10) days after the two brokers have rendered their opinions of Fair Market Rent as provided above. If the two brokers are unable to agree on the third broker
within said ten (10) day period, Landlord and Tenant shall mutually agree on the third broker within ten (10) days thereafter. If the parties do not agree on a third qualified broker within ten (10) days, then at the request of either
Landlord or Tenant, such third broker shall be promptly appointed by the then Presiding Judge of the Superior Court of the State of California for the County where the Building is located. The third broker shall be a person who has not previously
acted in such capacity for either party and must meet the qualifications stated above. 
 2.5 Impartial Appraisal. Within thirty
(30) days after its appointment, the third broker (the “Third Party”), shall render its written opinion by selecting either the Fair Market Rent determination made by Landlord’s broker or by Tenant’s broker. The Third
Party may not offer any different opinion or recommendation of Fair Market Rent. The Fair Market Rent determined in accordance with the foregoing procedure shall be binding on the parties. 

2.6 Appraisal Costs. Each party shall bear the cost of its own appraiser and one-half (1/2) the cost of the third appraiser. 

2.7 Acknowledgment of Rent. After the Fair Market Rent for the Extension Period has been established in accordance with the foregoing
procedure, Landlord and Tenant shall promptly execute an amendment to the Lease to reflect the Monthly Base Rent for the Extension Period. 

  
 2 

 2.8 Personal Option. The foregoing option to extend is personal to the original Tenant
signing the Lease and any assignee pursuant to a Permitted Transfer, but may not be assigned or transferred to or exercised by any other assignee, sublessee or transferee under a Transfer. 

  
 3EX-10.25

 Exhibit 10.25 

English Summary of Finnish language lease agreement dated June 27, 2013 and clarification agreement dated October 24, 2013 (the Lease)
currently by and between Elo Mutual Pension Insurance Company (the Landlord) and Biotie Therapies Corp. (the Tenant). 
  

	 	•	 	Leased property: The Tenant leases from the Landlord office premises of approximately 525.5 square meters, storage space of 50 square meters and 12 parking spaces located in the underground car park (the
Premises) in the address Joukahaisenkatu 6, FI-20520 Turku, Finland. The Lease was signed prior to the completion of the building and was originally entered into with YIT Rakennus Oy and subsequently transferred to Elo Mutual Pension
Insurance Company. 

  

	 	•	 	Term: The initial term of the agreement is three years beginning December 1, 2013. Unless either party has given notice six months prior to the end of the initial term, the lease will continue from December 1,
2016 with a mutual six month notice period. 

  

	 	•	 	Deposit: The Tenant must provide a bank guarantee or other security accepted by the Landlord amounting to a sum equivalent of three month’s capital and maintenance rent including value-added tax.

  

	 	•	 	Permitted use: The Premises are leased for office use as well as storage and parking use related thereto. The Tenant is obliged to use the Premises for purposes that entitle to full deduction of value-added tax.

  

	 	•	 	Sublease: The Tenant is not allowed to transfer any rights or obligations of the lease without the prior written consent of the Landlord. The Landlord has an unrestricted right to transfer the title of the shares
entitling to the possession of the business premises to a third party without the Tenant’s right to terminate the Lease. 

  

	 	•	 	Rent: The rent consists of a capital and maintenance rent. At the time of signing the clarification agreement, the monthly capital rent was EUR 8,679.90 for the office premises, EUR 325.30 for the storage space
and EUR 1,219.30 for the parking spaces. The monthly capital rents are adjusted semi-annually based on the Finnish Cost-of-living Index maintained by Statistics Finland, the Finnish public authority specifically established for statistics. The
monthly maintenance rent payable by the Tenant is based upon the budgeted costs of the real estate company for the upkeep of the property, corrected annually for the actual costs incurred. At the time of the signing of the clarification agreement
the monthly maintenance rent was EUR 2,716.65. 

  

	 	•	 	Insurances: Under the Lease, the Tenant procures and maintains the necessary permits and insurances. 

  

	 	•	 	Termination: See above “Term” for a description of the applicable notice periods. The statutory rights of both parties under Finnish law to terminate the Lease remain unaltered.

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