Document:

Exhibit 4.11  

CERTIFICATE OF ELIMINATION

OF

SERIES C SENIOR CONVERTIBLE PREFERRED STOCK

OF

NAPRO BIOTHERAPEUTICS, INC.  

Pursuant to Section 151(g) of the General Corporation Law of the State of Delaware  

        NaPro BioTherapeutics, Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware (the "Corporation"), does
hereby certify that the following resolutions respecting the Corporation's Series C Senior Convertible Preferred Stock, were duly adopted by the Corporation's board of directors: 

RESOLVED, that no shares of the Corporation's Series C Senior Convertible Preferred Stock are outstanding and that no shares of the
Series C Senior Convertible Preferred Stock will be issued subject to the certificate of designations previously filed with respect to the Series C Senior Convertible Preferred Stock;
and 

RESOLVED FURTHER, that the appropriate officers of the Corporation, and each of them with full authority to act without the others, are authorized and
directed to file with the Secretary of State of the State of Delaware a certificate pursuant to Section 151(g) of the General Corporation Law of the State of Delaware setting forth these
resolutions in order to eliminate from the Corporation's certificate of incorporation all matters set forth in the certificate of designations with respect to the Series C Senior Convertible
Preferred Stock.

 

        IN
WITNESS WHEREOF, the Corporation has caused this Certificate to be signed by its duly authorized officer this 25th day of August, 2003.

 

	

 	
 	

NAPRO BIOTHERAPEUTICS, INC.
	

 	
 	

By:	
 	

/s/  KAI LARSON      
 Kai Larson
 Vice President, General Counsel and Assistant Secretary

2Exhibit 4.12  

CERTIFICATE OF INCREASE

OF

SERIES B JUNIOR PARTICIPATING PREFERRED STOCK

OF

NAPRO BIOTHERAPEUTICS, INC.  

Pursuant to Section 151(g) of the General Corporation Law of the State of Delaware  

        NaPro BioTherapeutics, Inc., a corporation organized and existing under the General Corporation Law of the State of Delaware (the "Corporation"), does
hereby certify as follows: 

FIRST: In a Certificate of Designation filed with the Secretary of State of the State of Delaware on November 26, 1996, pursuant to
Section 151 of the General Corporation Law of the State of Delaware, the Corporation was authorized to issue 190,000 shares of Series B Junior Participating Preferred Stock, as a series
of the Corporation's authorized Preferred Stock, par value $0.001 per share. 

SECOND: The board of directors of the Corporation by resolution adopted August 25, 2003, duly authorized and directed that the number of shares
designated as the Corporation's Series B Junior Participating Preferred Stock and authorized for issuance be increased from 190,000 shares to 640,000 shares.

 

        IN
WITNESS WHEREOF, the Corporation has caused this Certificate to be signed by its duly authorized officer this 25th day of August, 2003.

 

	

 	
 	

NAPRO BIOTHERAPEUTICS, INC.
	

 	
 	

By:	
 	

/s/  KAI LARSON      
 Kai Larson
 Vice President, General Counsel and Assistant Secretary

1Filed by Automated Filing Services Inc. (604) 609-0244 - REGI U.S., INC. -Exhibit 4.1

 Exhibit 4.1

  CONSULTING AGREEMENT

	     This is an agreement
        dated and effective this 31st day of July, 2003 by and between
        JUAN CAMPO of 321 York Rd. 2nd Floor Towson, MD 21204 (hereinafter
        referred to as The Consultant), and REGI U.S., Inc. (RGUS) (hereinafter
        referred to as The Client).

       Recitals

         

	 	      I. The Client
        desires to obtain consulting services from The Consultant as
        more particularly described herein (“Scope of Services and Manner
        of Performance”).

            II. The Consultant is in the business
        of providing such consulting services and has agreed to provide the services
        on the terms and conditions set forth in this agreement.

            Now, therefore, in consideration of the
        faithful performance of the obligations set forth herein and other good
        and valuable consideration the receipt and sufficiency of which are hereby
        acknowledged, The Consultant and The Client hereby agree
        as follows.

        

      

	 Terms

          

	1.
   	Scope of Services. The Consultant will perform
        financial consulting for and on behalf of The Client in relation
        to interactions with broker-dealers, shareholders and members of the public
        and will consult with and advise The Client on matters pertaining
        to business modeling and development and the release of press, can perform
        services including:

      a. Phone Campaigns 

        b. Media submissions 

        c. Financial and business development consulting

          

	2.
   	Manner of performance. It is intended that The
      Consultant will provide research on the company and distribute company
      material to institutions, portfolio manager, broker-dealers, financial advisers
      and other persons whom The Consultant determines in its sole discretion,
      are capable of disseminating such information to the general public. The
      Consultant will act upon The Client’s behalf in the investment
      community, with existing shareholders, and the public. It is expressly agreed
      and acknowledged that The Consultant will not be expected to provide
      investor relations services, investment advice or recommendations regarding
      The Client to anyone. The Consultant will focus on contracting
      persons, generally though conventional communications in order to familiarize
      them with information concerning The Client. Additionally, The
      Consultant shall be available for advice and counsel to the officers
      and directors of The Client at such reasonable and convenient times
      and places as may be mutually agreed upon. Except as aforesaid, the time,
      place and manner of performance of the services hereunder, including the
      amount of time allocated by the Company, shall be determined at the sole
      discretion of The Company.
  
	3.
   	Status of Consultant. The Consultant shall
      act as an independent Consultant and not as an agent or employee of The
      Client and The Consultant shall make no representation as an
      agent or employee of The Client. The Consultant shall furnish
      insurance and be responsible for all taxes as an independent Consultant.
      The Consultant shall have no authority to bind The Client or
      incur other obligations on behalf of The Client. Likewise, The
      Client shall have no authority to bind on incur obligations on behalf
      of The Consultant.
   
	4. 	Disclosure of Material Events. The Client agrees
      to promptly disclose to The Consultant those events/discoveries which
      are known and/or anticipated that may conceivably may have an impact on
      the stock, business operations, future business, or public perception of
      The Client, as this has material impact on the ability and effectiveness
      of The Consultant and service rendered.

1

 

	5.
   	Confidentiality Agreement. In the event The Client
      discloses information to The Consultant that The Client considers
      to be secret, proprietary or non-public and so notifies The Consultant,
      The Consultant agrees to hold said information in confidence. Proprietary
      information shall be used by The Consultant only in connection with
      services rendered under this Agreement. Proprietary information shall not
      be deemed to include information under a) is in or becomes in the public
      domain without violation of this Agreement by The Client, or b) is
      rightfully received from a third entity having no obligation to The Client
      and without violation of this Agreement. In reciprocal, The Client
      agrees to hold confidential all trade secrets of and methods employed
      by The Consultant in fulfillment of services rendered.
  
	6.
   	Indemnification. The Client agrees to indemnify
      and hold harmless The Consultant against any losses, claims, damages,
      liabilities and/or expenses (including any legal or other expenses reasonably
      incurred in investigating or defending any action or claim in respect thereof)
      to which The Consultant is willing and capable of providing services
      on a “Best Efforts” basis. The Consultant cannot be held
      liable for negative stock activity unless it can be shown that this activity
      comes as a direct result of willful, negligent, in appropriate and illegal
      representation or misrepresentation by The Consultant. The Consultant
      cannot and will not provide a guarantee as to anticipated stock price,
      performance and/or trading volume. The Consultant does intend to
      sell all of the stock provided as payment by The Client. Payment
      by The Client to The Consultant is irrevocable and irreversible.
    
	7.	 Conflict of Interest. The Consultant shall
      be free to perform services for other persons. The Consultant will
      notify The Client of its performance of consulting services for any
      other Client that could conflict with its obligations under this agreement.
  
	8.
   	Term. Refer to Schedule A.
  
	9.
   	Payment. Refer to Schedule B.
  
	10.
   	Payment Instructions. Refer to Schedule C.
  
	11.
   	Severability. This agreement may be dissolved at any
      time at the express consent of both parties. In the event any part of this
      agreement shall be held to be invalid by any competent court or arbitration
      panel, this agreement shall be interpreted as if only that part is invalid
      and that the parties to this agreement will continue to execute the rest
      of this agreement to the best of their abilities unless both parties mutually
      consent to the dissolution of this agreement.

        
	     This agreement
        shall be interpreted accordance with laws of the State of Maryland. This
        agreement and attached schedules constitutes the entire contract of the
        parties with respect to the matters addressed herein and no modifications
        of this agreement shall be enforceable unless in writing signed by both
        The Consultant and The Client. This agreement is not assignable
        by either party without the consent of the other.

            In witness whereof The Consultant and
        The Client have caused this agreement to be executed on the date
        indicated in Schedule A.

       REGI U.S., Inc.

       Authorized person x /s/ John Robertson Title: President
        Date: July 31, 2003

        I hereby certify that I agree to the terms of the contract above and am
        authorized to enter into a binding contract.

      

      JUAN CAMPO

        /s/ Juan Campo

        Date 07/31/03

        I hereby certify that I agree to the terms of the contract above and am
        authorized to enter into a binding contract.

      

2

 Schedule A 

 Term of Commitment 

 The Consultant shall perform consulting services for The Client
  for 2 months or until the company has determined upon that agreed upon objectives
  have been met and the terms of commitment have been fulfilled. 

 Such services shall commence upon receipt of the first payment as outlined
  in Schedule B, to be renewed for 2 additional months subject to adjustments
  to the issuance of the shares based on the price of the shares 10 day average
  price prior to the end of the 2 month period and subject for approval by both
  REGI U.S. and Juan Campo. 

 Schedule B 

	150,000 free trading shares for the 2 months consulting services
	150,000 warrants(1) exercisable @ .12 - to be exercised within
    30 days
	125,000 warrants(1) exercisable @. 20 - to be exercised within
    60 days
	150,000 warrants(1) exercisable @ .30 - to be exercised within
    90 days subject to a renewed consulting agreement.
	125,000 warrants(1) exercisable @. 50 - to be exercised within
    90 days subject to a renewed consulting agreement.

 (1) with piggyback registration rights. The warrant is attached hereto as
  Schedule D. 

 Schedule C 

 Payment shall be made per verbal agreement. 

 3

 Schedule D 

 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED
  UNDER THE SECURITIES ACT OF 1933, AS AMENDED ("1933 ACT"), OR ANY STATE SECURITIES
  LAWS AND SHALL NOT BE SOLD, PLEDGED, HYPOTHECATED, DONATED, OR OTHERWISE TRANSFERRED,
  WHETHER OR NOT FOR CONSIDERATION, BY THE HOLDER EXCEPT UPON THE ISSUANCE TO
  THE COMPANY OF A FAVORABLE OPINION OF ITS COUNSEL OR THE SUBMISSION TO THE COMPANY
  OF SUCH OTHER EVIDENCE AS MAY BE SATISFACTORY TO COUNSEL FOR THE COMPANY, IN
  EITHER CASE, TO THE EFFECT THAT ANY SUCH TRANSFER SHALL NOT BE IN VIOLATION
  OF THE 1933 ACT AND APPLICABLE STATE SECURITIES LAWS. 

 REGI U.S., INC.  

 Common Stock Purchase Warrant to

  Purchase up to 550,000 Shares of Common Stock 

 This Common Stock Purchase Warrant is issued to: 

 JUAN CAMPO

  321 York Road, 2nd Floor

  Towson, MD 21204

 by REGI U.S., INC., an Oregon corporation (hereinafter called the "Company",
  which term shall include its successors and assignors, 

 FOR VALUE RECEIVED and subject to the terms and conditions hereinafter set
  out, the registered holder of this Warrant as set forth on the books and records
  of the Company (the "Holder") is entitled upon surrender of this Warrant to
  purchase from the Company up to 550,000 fully paid and nonassessable shares
  of Common Stock (the "Common Stock"), at the Exercise Price (as defined below)
  per share. 

 This Warrant shall expire at the close of business on October 31, 2003. 

 1. (a) The right to purchase shares of Common Stock represented by this Warrant
  may be exercised by the Holder, in whole or in part, by the surrender of this
  Warrant (properly endorsed if required) at the principal office of the Company
  at #1103 – 11871 Horseshoe Way, Richmond, BC V7A 5H5 (or such other office
  or agency of the Company as it may designate by notice in writing to the Holder
  at the address of the Holder appearing on the books of the Company), and upon
  completion of provision of services as set out in the Consulting Agreement between
  the Company and Juan Campo dated July 31, 2003. The Company agrees that the
  shares of Common Stock so earned shall be deemed to be issued to the Holder
  as the record owner of such shares of Common Stock as of the close of business
  on the date on which this Warrant shall have been surrendered and payment made
  for such shares of Common Stock as aforesaid. Certificates for the shares of
  Common Stock so purchased shall be delivered to the Holder within a reasonable
  time. 

 (b) This Warrant may be exercised to acquire, from and after the date hereof,
  the number of shares of Common Stock set forth on the first page hereof (subject
  to adjustments described in this Warrant); provided, however, the right hereunder
  to purchase such shares of Common Stock shall expire at 5:00 p.m. Pacific Standard
  time on October 31, 2003. 

 4

 2. This Warrant is being issued by the Company pursuant to
  the terms of the Consulting Agreement dated July 31, 2003. 

 3. The Company covenants and agrees that all Common Stock
  upon issuance against payment in full of the Exercise Price by the Holder pursuant
  to this Warrant will be validly issued, fully paid and nonassessable and free
  from all taxes, liens and charges with respect to the issue thereof (except
  to the extent resulting from the Holder's own circumstances, actions or omissions).
  The Company covenants and agrees that during the period within which the rights
  represented by this Warrant may be exercised, the Company will have at all times
  authorized, and reserved for the purpose of issue or transfer upon exercise
  of the rights evidenced by this Warrant, a sufficient number of shares of Common
  Stock to provide for the exercise of the rights represented by this Warrant,
  and will procure at its sole expense upon each such reservation of shares the
  listing thereof (subject to issuance or notice of issuance) on all stock exchanges
  on which the Common Stock is then listed or inter-dealer trading systems on
  which the Common Stock is then traded. The Company will take all such action
  as may be necessary to assure that such shares of Common Stock may be so issued
  without violation of any applicable law or regulation, or of any requirements
  of any national securities exchange upon which the Common Stock may be listed
  or inter-dealer trading system on which the Common Stock is then traded. The
  Company will not take any action which would result in any adjustment in the
  number of shares of Common Stock purchasable hereunder if the total number of
  shares of Common Stock issuable pursuant to the terms of this Warrant after
  such action upon full exercise of this Warrant and, together with all shares
  of Common Stock then outstanding and all shares of Common Stock then issuable
  upon exercise of all options and other rights to purchase shares of Common Stock
  then outstanding, would exceed the total number of shares of Common Stock then
  authorized by the Company's Restated and Amended Articles of Incorporation,
  as then amended. 

 4. The exercise price of the warrants are as follows:

	150,000 warrants exercisable @ .12 - to be exercised within 30 days
	125,000 warrants exercisable @. 20 - to be exercised within 60 days
	150,000 warrants exercisable @ .30 - to be exercised within 90 days subject
    to a renewed consulting agreement.
	125,000 warrants exercisable @. 50 - to be exercised within 90 days subject
    to a renewed consulting agreement.

 5. The shares of Common Stock issuable upon the exercise of this Warrant shall
  be registered by the Company pursuant to a Form S-8 to be filed with the Securities
  and Exchange Commission on or prior to August 30, 2003. 

 6. The terms defined in this paragraph, whenever used in this Warrant, shall,
  unless the context otherwise requires, have the respective meanings hereinafter
  specified. The term "Common Stock" shall mean and include the Company's Common
  Stock, authorized on the date of the original issue of this Warrant and shall
  also include in case of any reorganization, reclassification, consolidation,
  merger or sale of assets of the character referred to in Section 4 hereof, the
  stock, securities or assets provided for in such paragraph. The term "outstanding"
  when used with reference to Common Stock shall mean at any date as of which
  the number of shares thereof is to be determined, all issued shares of Common
  Stock, except shares then owned or held by or for the account of the Company.
  The term "1933 Act" shall mean the Securities Act of 1933, as amended, or any
  successor Federal statute, and the rules and regulations of the Securities and
  Exchange Commission, or any other Federal agency then administering the 1933
  Act, thereunder, all as the same shall be in effect at the time. 

 5

 7. This Warrant is exchangeable, upon the surrender hereby by the Holder at
  the office or agency of the Company, for new Warrants of like tenor representing
  in the aggregate the right to subscribe for and purchase the number of shares
  of Common Stock which may be subscribed for and purchased hereunder, each of
  such new Warrants to represent the right to subscribe for and purchase such
  number of shares of Common Stock as shall be designated by the Holder at the
  time of such surrender. Upon receipt of evidence satisfactory to the Company
  of the loss, theft, destruction or mutilation of this Warrant or any such new
  Warrants and, in the case of any such loss, theft, or destruction, upon delivery
  of a bond of indemnity, reasonably satisfactory to the Company, or, in the case
  of any such mutilation, upon surrender or cancellation of this Warrant or such
  new Warrants, the Company will issue to the Holder a new Warrant of like tenor,
  in lieu of this Warrant or such new Warrants, representing the right to subscribe
  for and purchase the number of shares of Common Stock which may be subscribed
  for and purchased hereunder. 

 8. The Company will at no time close its transfer books against the transfer
  of this Warrant or of any shares of Common Stock issued or issuable upon the
  exercise of this Warrant in any manner which interferes with the timely exercise
  of this Warrant. This Warrant shall not entitle the Holder to any voting rights
  or any rights as a shareholder of the Company. The rights and obligations of
  the Company, of the Holder, and of any holder of shares of Common Stock issuable
  hereunder, shall survive the exercise of this Warrant. 

 9. This Warrant sets forth the entire agreement of the Company and the Holder
  of the Common Stock issuable upon the exercise of this Warrant with respect
  to the rights of the Holder and the Common Stock issuable upon the exercise
  of this Warrant, notwithstanding the knowledge of such Holder of any other agreement
  or the provisions of any agreement, whether or not known to the Holder, and
  the Company represents that there are no agreements inconsistent with the terms
  hereof or which purport in any way to bind the Holder of this Warrant or the
  Common Stock. 

 10. The validity, interpretation and performance of this Warrant and each
  of its terms and provisions shall be governed by the laws of the State of Oregon.

 IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by its
  duly authorized officer under its corporate seal and dated as of July 31, 2003.

	REGI U.S., INC.
	 
	/s/ John G. Robertson
	 
	By: /s/ “ John G. Robertson”
	   Name: John G. Robertson
	   Title: President

 6

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