Document:

Second Amendment to Lease

 Exhibit 10.57 
 SECOND AMENDMENT TO LEASE 
 THIS SECOND AMENDMENT TO LEASE (this “Amendment”), dated
as of February 23, 2006 (the “Amendment Date”), is entered into by and between BMR-201 INDUSTRIAL ROAD LLC, a Delaware limited liability company (“Landlord”), and NUVELO, INC., a Delaware corporation
(“Tenant”). Landlord and Tenant shall each be referred to herein as a “Party” and collectively as the “Parties.” Capitalized terms not otherwise defined herein shall have the meanings assigned to
them in the Existing Lease (as defined below). 
 RECITALS 
 WHEREAS, Landlord and Tenant are parties to that certain Lease dated as of January 11, 2005 (the “Original Lease”), as amended by
that certain First Amendment to Lease dated as of May 10, 2005 (the “First Amendment” and, collectively with the Original Lease, and as the same may have been otherwise amended, modified or supplemented from time to time, the
“Existing Lease”), pursuant to which Tenant leases from Landlord certain space (the “Current Premises”) located in the Project; and 
 WHEREAS, Tenant has exercised the Expansion Option as of February 14, 2006; and 
 WHEREAS, the Parties
desire to amend the Existing Lease to reflect Tenant’s exercise of the Expansion Option. 
 NOW, THEREFORE, for good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 
 AGREEMENT

 1. Premises. As of the Expansion Rent Commencement Date (as defined below), (a) the term “Premises”
shall mean those premises depicted on Exhibit A attached hereto consisting of approximately 7,624 rentable square feet and (b) the total “Rentable Area” under Section 2 of the Original Lease (as amended by
the First Amendment) shall equal sixty-nine thousand four hundred fifty (69,450) rentable square feet. 
 2. Delivery of Expansion
Space. Landlord shall deliver possession of the Expansion Space to Tenant on or before March 16, 2006, for Tenant’s construction of tenant improvements (the “Expansion Tenant Improvements”), which Expansion Tenant
Improvements shall be constructed in accordance with the requirements contained in the Existing Lease for tenant improvements and alterations. 
 3. Rent Commencement. Tenant shall be liable for Rent for the Expansion Space commencing on the date (the “Expansion Rent Commencement Date”) that is the earlier of (a) the date on which the Expansion Tenant
Improvements are Substantially Complete and (b) August 13, 2006. For purposes of this Section 3, the term “Substantially Complete” shall mean the earliest to occur of (a) the date of issuance of a
temporary certificate of occupancy for the Expansion Space, (b) the date Tenant receives a Certificate of Substantial Completion in the form of the American Institute of Architects document G704 executed by the project architect and the general
contractor, (c) the date of substantial completion of the Expansion Tenant Improvements, subject only to such minor work as would not unreasonably interfere with Tenant’s occupancy and use of the Expansion Space for the Permitted Use, and
(d) the date on which Tenant commences using the Expansion Space for the Permitted Use. 
 4. Expansion Space Rent. As of the
Expansion Rent Commencement Date, Tenant shall pay Rent on the Expansion Space at the rate set forth in the Existing Lease for the Current Premises. For purposes of calculating Rent increases pursuant to Section 5 of the Original Lease,
the Rent Commencement Date for the Expansion Space shall be deemed to be the same as the Rent Commencement Date for the Current Premises, and the initial Lease Term for the Expansion Space shall expire on the same date as the initial Lease Term for
the Current Premises. As of the Expansion Rent Commencement Date, “Tenant’s Pro Rata Share of Operating Expenses” shall equal seventy-eight and sixty-four hundredths percent (78.64%) with respect to Operating Expenses for
the Building, and forty-two and thirty-eight hundredths percent (42.38%) with respect to Operating Expenses for the Project. Within ten (10) business days of the Expansion Rent Commencement Date, Tenant shall deliver to Landlord an 

 
Acknowledgement of Expansion Rent Commencement Date in the form attached as Exhibit B hereto. 
 5. Security Deposit. Upon execution of this Amendment, Tenant shall deposit with Landlord Fifty-Three Thousand Seven Hundred Forty-Nine Dollars
($53,749) as additional Security Deposit (the “Expansion Security Deposit”) to reflect the expansion of the Premises, increasing the total Security Deposit to Four Hundred Eighty-Nine Thousand Six Hundred Twenty-Three Dollars
($489,623). The provisions in the Original Lease applicable to the Security Deposit shall apply to the Expansion Security Deposit. 
 6.
Expansion Tenant Improvement Allowance. Landlord shall make available to Tenant an allowance (the “Expansion TI Allowance”) of One Million Six Thousand Three Hundred Sixty-Eight Dollars ($1,006,368) for construction by Tenant
of the Expansion Tenant Improvements, to be spent in accordance with the requirements contained in the Existing Lease for tenant improvements and alterations. Any portion of the Expansion TI Allowance that remains unexpended by Tenant as of
February 14, 2007, shall no longer be available to Tenant, and Tenant shall forfeit all rights thereto. 
 7. Termination of
Expansion Option. Section 29 of the Original Lease (as amended by the First Amendment) is hereby deleted and of no further force or effect. 
 8. Lease Defined. Except as expressly amended by this Amendment, the Existing Lease shall remain unmodified and in full force and effect, enforceable in accordance with its terms. From and after the Amendment
Date, the term “Lease,” when used in the Existing Lease, shall mean the Existing Lease as amended by this Amendment. 
 9.
Counterparts. This Amendment may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument executed on the date first set forth. 
 10. Authorization. Each individual executing this Amendment on behalf of its respective Party represents and warrants that the execution and
delivery of this Amendment on behalf of such Party is duly authorized, and that he or she is authorized to execute and deliver this Amendment on behalf of such Party. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF the parties hereto have signed this Amendment as of the date first above
written. 
  

					
	LANDLORD:	 	
		
	 BMR-201 INDUSTRIAL ROAD LLC,
 a Delaware
limited liability company
	 	
			
	By:	 	

	 	
	 Name:
	 	 Gary A. Kreitzer
	 	
	 Its:
	 	 Executive Vice President
	 	
		
	TENANT:	 	
		
	 NUVELO, INC.,
 a Delaware corporation
	 	
			
	By:	 	

	 	3/10/06
	 Name:
	 	 Gary Titus
	 	
	 Its:
	 	 VP Finance & CFO
	 	

 EXHIBIT A 
 PREMISES 
 [See attached] 
 

 
 

 

 EXHIBIT B 
 FORM OF ACKNOWLEDGEMENT OF EXPANSION RENT COMMENCEMENT DATE 
 THIS ACKNOWLEDGEMENT OF EXPANSION RENT
COMMENCEMENT DATE is entered into as of [                    ], 2006, with reference to that certain Lease dated as of January 11, 2005,
as amended by that certain First Amendment to Lease dated as of May 10, 2005, and that certain Second Amendment to Lease dated as of February [    ], 2006 (the “Second Amendment” and, collectively,
the “Lease”), by NUVELO, INC., a Delaware corporation (“Tenant”), in favor of BMR-201 INDUSTRIAL ROAD LLC, a Delaware limited liability company (“Landlord”). All capitalized terms used herein
without definition shall have the meanings ascribed to them in the Lease. 
 Tenant hereby confirms the following: 
 1. Tenant accepted possession of the Expansion Space on March [    ], 2006. 
 2. The Expansion Space is in good order, condition and repair. 
 3. The Expansion Tenant Improvements have been Substantially Complete (as defined in the Second Amendment). 
 4. All conditions of the Lease to be performed by Landlord as a condition to the full effectiveness of the Lease with regards to the Expansion Space have been satisfied, and Landlord has fulfilled all of its duties in the nature of
inducements offered to Tenant to lease the Expansion Space. 
 5. In accordance with the provisions of Section 3 of the Second
Amendment, the Expansion Rent Commencement Date is [            ], 2006. 
 6. The Lease is in full force and effect, and the same represents the entire agreement between Landlord and Tenant concerning the Premises. 
 7. Tenant has no existing defenses against the enforcement of the Lease by Landlord, and there exist no offsets or credits against Rent owed or to be owed by Tenant. 
 8. The obligation to pay Rent is presently in effect and all Rent obligations on the part of Tenant under the Lease with respect to the Expansion Rent
Commencement Date commenced to accrue on [            ], 2006. 
 9. The
undersigned Tenant has not made any prior assignment, transfer, hypothecation or pledge of the Lease or of the rents thereunder or sublease of the Premises or any portion thereof. 
 [REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, the parties hereto have executed this Acknowledgment of Expansion Rent Commencement
Date as of [            ], 2006. 
  

			
	 TENANT:
  
 NUVELO, INC.,
 a Delaware corporation

		
	 By:
	 	  
	Name:	 	  
	Title:Offer Letter between Transmedia Network and Megan E. Flynn

 Exhibit 10.22 
 

 
 Gene M. Henderson 
 President & CEO 
 August 10, 2000 
 Megan E. Flynn 
 98 West 45 Street 
 Bayonne, New Jersey 07002 
 Dear Megan: 
 On behalf of
Transmedia Network Inc. (“the Company”), I am very pleased to offer you the position of Vice President, Partner Relationship Management. In this position you will initially report to me, but the reporting relationship may change as the
marketing organization at Transmedia evolves. 
 The terms of the offer include the following: 
  

	1.	Duties and Responsibilities – As Vice President, Partner Relationship Management, you will immediately assume responsibility for the management and care of
several of Transmedia’s large partnerships including organizations such as AOL-AA, United Air Lines, MBNA, AT&T, and others. Further, you will be tasked with spearheading the design, staffing and execution of a partner relationship
management process within the Company and generally contributing to the overall marketing and member stimulation efforts within Transmedia and its affiliates. 

  

	2.	Starting Date – You will begin your employment on September 5, 2000. You will receive a signing bonus of $10,000 on your first day. 

 

	3.	Base Salary – Your annual base salary is $112,000 and is paid weekly. Your compensation will be reviewed after six months, annually thereafter.

  

	4.	Annual Bonus – You will be eligible for a cash bonus in fiscal 2001 (October 1, 2000- September 30,2001), of up to 25% of base salary at plan. 50% of the
bonus potential at plan ($14,000) is guaranteed in the first year . Bonus metrics will be established within 30 days of the start of the fiscal year. If the Company exceeds plan, bonus potential will increase linearly. 

  

	5.	 Stock Options – Subject to the terms and conditions of the Company’s existing 1996 Long Term Incentive Plan (“LTIP”), you will
receive ten thousand (10,000) stock 

  

 11900 Biscayne Boulevard, North Miami. Florida 33181-9915 • (305) 892-3321 •
(800) 438-9013 • FAX (305) 892-3342 

	 	 
options upon the starting date of your employment. The strike price of the options will be the closing price of Transmedia stock on your first day of
employment with the company. 

  

	 	•	 	Vesting – These options will vest ratably on each of the first through the fourth anniversaries of your starting date. Vested options will remain exercisable by
you for ten years following the date of their grant or, in the event of the termination of your employment, for the period provided in the LTIP. If you are terminated for any reason other than “cause” (as defined below), that period is
ninety days from the date of termination. All unvested options will terminate upon the termination of your employment for any reason. 

  

	 	•	 	Annual Grants – You will be eligible for annual option grants at the discretion of the CEO and the Compensation Committee of the Board. 

 

	6.	Employee Benefits – You will be entitled to all standard Transmedia benefits including a free iDine Prime membership with an employee discount of 33% of
dining spend in all iDine restaurants. 

  

	7.	Additional Benefits – Any reasonable relocation expenses incurred by you as a result of your move from New York/New Jersey to Florida will be reimbursed by the
Company, including, but not limited to the physical move of your household contents, house hunting and temporary living expenses. 

  

	8.	Non-Compete – In the event you voluntarily or involuntarily leave Transmedia’s employ, for a period of one year following your termination date or, if
longer, for as long as you are receiving severance payments and benefits, you will not directly of indirectly (i) be employed by or perform work as a director, officer, independent contractor, partner or consultant for any business in which the
Company or any of its affiliates is engaged at such date in any geographic region in which the Company conducts business (“business” shall be defined as the marketing and sale of any program substantially similar to the Transmedia program
and/or the marketing and sale of discount restaurant, hotel, resort, travel or leisure products or services as more particularly set forth in the Company’s 10-K filing effective as the date of this offer). 

  

	9.	Confidentiality – You shall treat as confidential and not disclose to any person not affiliated with Transmedia all non-public and proprietary information and
data about the business, operations, employees, programs, plans and financial results, projections and budgets of Transmedia and its affiliates which are disclosed to you during your employment. You will be asked to sign the Company’s standard
confidentiality agreement which agreement shall survive the termination of your employment for any reason. 

 On behalf of Transmedia Network Inc., I am delighted to offer you the position of Vice President, Partner Relationship
Management and I look forward to your joining our team. If you have any questions, please contact me directly at 305-892-3314. 
  

							
	 Sincerely,
	 		 	 Agreement Accepted:

			
	 /s/ Gene M. Henderson
	 		 	 /s/ Megan E. Flynn

	 Gene M. Henderson
	 		 	 Megan E. Flynn

	 President and CEO
	 		 		 	
		 		 	 Date:
	 	 8/14/00

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00099-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00099-of-00352.parquet"}]]