Document:

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                                                                   EXHIBIT 10.29

                               AGREEMENT REGARDING

                        ASSIGNMENT OF PURCHASE AGREEMENT

     This AGREEMENT is made between Richard E. Beauvais ("Beauvais") and CuraGen
Corporation ("CuraGen") as of April 10th, 2001.

     WHEREAS, Beauvais has entered into a Purchase Agreement with Marc L. Nevas,
Trustee for Bittersweet Associates ("Bittersweet"), a copy of which is attached
hereto as Exhibit A ("Purchase Agreement"), pursuant to which Bittersweet is to
convey to Beauvais certain land in Branford, Connecticut more particularly
described in Exhibit A of the Purchase Agreement (the "Property") subject to the
terms and conditions of the Purchase Agreement.

     WHEREAS, CuraGen has requested that Beauvais assign his interest in the
Purchase Agreement to CuraGen and Beauvais has agreed to do so in consideration
of a payment from CuraGen to Beauvais more particularly described below;

     WHEREAS, prior to the assignment, CuraGen has requested that Beauvais cause
Bittersweet to consent to such assignment as more particularly described below;

     NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, Beauvais and CuraGen agree as
follows:

     1. Concurrently with the execution and delivery of this Agreement, Beauvais
and CuraGen will execute the Assignment and Assumption Agreement attached hereto
as Exhibit B ("Assignment and Assumption Agreement");

     2. No later than April 12, 2001, Beauvais will cause Bittersweet to consent
to the Assignment and Assumption Agreement by executing and delivering the same
to Beauvais and CuraGen. Upon the execution and delivery by Bittersweet the
Assignment and Assumption Agreement shall be considered effective and shall bear
the date of such execution and delivery.

     3. No later than April 12, 2001, Beauvais shall deliver to CuraGen(a) all
reports, test data, plans, drawings, diligence matters and related information
(in electronic as well as paper format, if available) which relate to the
Property and are in Beavais' possession or control and (b) if and to the extent
the Plans and Materials have been prepared by a third party, the acknowledgement
in writing of such third party that it consents to CuraGen's use thereof without
liability or cost to CuraGen and that such third party has been paid in full for
the preparation of such Plans and Materials.

     4. In consideration for the assignment of the Purchase Agreement and the
Plans and Materials, CuraGen shall pay to Beauvais the Assignment Payment
(hereinafter defined) upon the consummation of the purchase and sale pursuant to
the Purchase Agreement (the "Property Closing"). Concurrently with the execution
and delivery hereof, CuraGen shall

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reimburse Beauvais the Fifty Thousand Dollar ($50,000) security deposit Beauvais
has delivered to Bittersweet's attorney pursuant to the Purchase Agreement.

     5. As used herein, "Assignment Payment" shall mean Zero ($0.00), provided,
however, that in the event CuraGen and Beauvais or an entity owned or controlled
by Beauvais have failed to enter into a mutually satisfactory agreement on or
before the date of the Property Closing pursuant to which Beauvais or such an
entity is engaged by CuraGen on a fee basis to develop and build improvements on
the Property, "Assignment Payment" shall mean One Million Five Hundred Dollars
($1,500,000). The Assignment Payment shall be made by certified, cashiers or
bank treasurer's check, or by wire transfer.

     6. Beauvais represents and warrants that:

     (a) the copy of the Purchase Agreement attached hereto as Exhibit A is a
true, accurate and complete copy of the Purchase Agreement;

     (b) the Purchase Agreement reflects all of the agreements of Beauvais and
Bittersweet which relate in any way to the Property; Beauvais shall not assign
or otherwise transfer any interest in the Purchase Agreement or agree to do so
while this Agreement remains in effect;

     (c) the Purchase Agreement has not been amended or modified in any respect;

     (d) Beauvais is not in default of any of the terms and conditions of the
Purchase Agreement and, to the best of Beauvais' knowledge, Bittersweet is not
in default of any of the terms and conditions of the Purchase Agreement;

     (e) to the best of Beauvais' actual knowledge, there are no circumstances
or conditions relating to the Property which would prevent CuraGen from
developing the Property other than the need to obtain regulatory permits and
approvals;

     (f) Beauvais has not made, and, to Beauvais' actual knowledge, Bittersweet
has not made, any commitments to governmental authorities, adjoining or
surrounding property owners, civic associations, utility companies or other
persons or entities, which would in any manner be binding upon CuraGen or
materially limit CuraGen from utilizing or developing the Property;

     (g) to Beauvais' actual knowledge, there is no material violation of any
law, ordinance, rule, regulation or order affecting the Property;

     (h) Beauvais has no actual knowledge that any part of the Property is
assessed as farmland, agricultural land, or any other type of assessed property
that is entitled to rollback taxes or deferred taxes or is subject to a right of
first refusal or other pre-emptive right held by any governmental authority;

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     (i) to Beauvais' actual knowledge, there are no actions, suits or
condemnation proceedings pending affecting any portion of the Property, at law
or in equity, or before or by any federal, state, municipal or other
governmental department, commission, board, bureau, agency or instrumentality,
whether domestic of foreign;

     (j) to Beauvais' actual knowledge, there are no attachments, executions,
assignments for the benefit of creditors or voluntary or involuntary proceedings
in bankruptcy pending against Beauvais or Bittersweet; and

     (k) Beauvais has no actual knowledge of any pending improvements, liens or
special assessments to be made against the Property by any governmental
authority.

The provisions of this Section 6 shall survive the termination of this Agreement
and the Property Closing.

     7. Beauvais agrees and covenants that:

     (a) Beauvais will not amend the Purchase Agreement and will not permit the
Purchase Agreement to be terminated or to expire; and

     (b) Beauvais shall not assign or otherwise transfer any interest in the
Purchase Agreement or agree to do so while this Agreement remains in effect.

     (c) Beauvais will forward to CuraGen copies of all correspondence and
notices between Beauvais and Bittersweet contemporaneously with the receipt or
transmission of such correspondence or notices, and will give CuraGen written
notice of any defaults by either party under the Purchase Agreement.

     8. Beauvais and CuraGen each hereby represent and warrant to the other that
it has not employed any broker, agent or finder in connection with the Property
or the transactions contemplated hereby. Each will protect, indemnify and hold
the other harmless from and against all loss, cost, damages, and exposure,
including reasonable attorney's fees, arising out of any breach of this
representation and warranty. The foregoing indemnity in this Section 8 will
survive the Property Closing or the earlier termination of this Agreement.

     9. Any notices, requests, demands or other communications hereunder will be
in writing and sent by certified mail, return receipt requested, or by
commercial overnight or other courier service providing a receipt upon delivery,
addressed as follows:

TO BEAUVAIS:

Richard E. Beauvais
61 Soundview Road
P.O. Box 855
Guilford, CT 06437

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COPY TO:

TO CURAGEN:       CuraGen Corporation
                  555 Long Wharf Drive, 11th Floor
                  New Haven, CT 06511
                  Attn: Terrie B. Atkinson

COPY TO:          Mintz, Levin, Cohn, Ferris, Glovsky
                    and Popeo, P .C.
                  One Financial Center
                  Boston, Massachusetts 02111
                  Attn: Joshua Davis, Esquire

All such notices will be deemed given when delivered to the addressee, as
evidenced by the return receipt provided to the sending party by the United
States Postal Service or when delivery is refused or confirmation of delivery or
refusal of delivery by the commercial overnight or other courier service, as the
case may be. Any changes to the above addressees and/or addresses will be
effective upon the giving of a notice of any and all such changes to the other
party in accordance with the terms of this subparagraph.

     10. Notwithstanding any other provision of this Agreement, or any
agreements, contracts or obligations which may derive herefrom, nothing herein
shall be construed to make the parties hereto partners or joint venturers, or to
render either party liable for any of the debts or obligations of the other
party, it being the intention of this Agreement to merely create the
relationship of assignor and assignee with regard to the Purchase Agreement.

     11. This Agreement constitutes the entire agreement between the parties
pertaining to the subject matter contained herein and supersedes all prior
agreements, representations and all understanding of the parties.

     12. No change or modification of this Agreement shall be valid unless the
same is in writing and executed by Beauvais and CuraGen. No purported or alleged
waiver of any of the provisions of this Agreement is binding or effective unless
in writing and signed by the party against whom it is sought to be enforced.

     13. CuraGen has the right to assign this Agreement without the consent of
Seller to any entity that is owned or controlled by or in common control with
CuraGen.

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     14. This Agreement shall be governed by and construed in accordance with
the laws of the State of Connecticut.

     15. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

     16. Time is of the essence in this Agreement.

     WITNESS the execution hereof as of the day and year above written.

                                        ---------------------------------
                                        Richard E. Beauvais

                                        CuraGen Corporation

                                        By: -----------------------------
                                            Jonathan Rothberg
                                            Founder, Chairman and
                                            Chief Executive Officer

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                                    EXHIBIT A

                          [COPY OF PURCHASE AGREEMENT]

<PAGE>

                                    EXHIBIT B

               ASSIGNMENT AND ASSUMPTION OF AGREEMENT WITH CONSENT

     The undersigned, Richard E. Beauvais ("Beauvais"), for good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged,
hereby assigns all of his right, title and interest in and to that certain
Purchase Agreement dated as of April 12, 2001, between Marc L. Nevas, Trustee
for Bittersweet Associates, as seller, and Richard E. Beauvais, as buyer, to
CuraGen Corporation ("CuraGen") and CuraGen hereby agrees to assume the
obligations of the buyer thereunder, effective as of the date hereof, such
assignment being consented to by the seller as evidenced by its countersignature
below.

     IN WITNESS WHEREOF, this Assignment and Assumption Agreement has been
executed under seal as of this 12 day of April, 2001.
                              ---       -------

                                             -------------------------------
                                             Richard E. Beauvais

                                             CuraGen Corporation

                                             By: ---------------------------
                                                 Jonathan Rothberg
                                                 Founder, Chairman and
                                                 Chief Executive Officer

The undersigned hereby consents
to the foregoing assignment
and certifies that no default
exists under the Purchase Agreement:

------------------------------------
Marc L. Nevas, Trustee for
Bittersweet Associates, a
Connecticut joint venture

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EXHIBIT "A"

                               PURCHASE AGREEMENT

     AGREEMENT made this 5th, day of April, 2001 by and between MARC L. NEVAS,
TRUSTEE FOR BITTERSWEET ASSOCIATES, a Connecticut Joint Venture having its
principal place of business in the Town of Westport, County of Fairfield and
State of Connecticut, (hereinafter referred to as "Seller") acting herein by
RICHARD E. BEAUVAIS, of 61 Soundview Road, P.O. Box 855, Guilford, Connecticut
06437, (hereinafter referred to as "Purchaser").

1. Purchase and Sale.
   -------------------

     Seller agrees to sell and convey to Purchaser, and Purchaser agrees to
purchase from Seller, all that certain piece or parcel of land with all
improvements thereon and all appurtenances thereto, as more particularly
described on Schedule A attached hereto and made a part hereof, which is located
at 771-779 East Main Street in the Town of Branford, County New Haven State of
Connecticut. (The aforesaid land and improvements are hereinafter collectively
referred to as the "Property".)

2. Personal Property.
   -------------------

     The parties agree that all personal property owned by Seller and presently
located on and used in connection with the Property is included in the sale,
including screens, storm windows, venetian blinds, curtain rods and fixtures,
wall to wall carpeting, awnings, shades, automatic hot water heaters (except
rented water heaters), heating fixtures (except portable heaters) and lighting
fixtures (except rented or tenant owned lamps and lighting fixtures) and plants
and shrubbery.

3. Purchase Price.
   ----------------

     The consideration for the sale and transfer of the Property is the sum of
TWO MILLION TWO HUNDRED SIXTY-TWO THOUSAND FIVE HUNDRED and 00/100
($2,262,500.00) DOLLARS payable as follows:

     (a) Before or upon the signing of this Agreement,
     receipt of which is hereby acknowledged, subject
     to collection;                                             $    50,000.00

     (b) Upon the delivery of the deed, by certified
     check or official bank check drawn on a bank which
     is a member of the New York Clearing House, or the
     proceeds of which are immediately available to
     Seller at a local bank;                                    $ 2,212,500.00
                                                                --------------
              TOTAL                                             $ 2,262,500.00
                                                                ==============

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Any down payment made hereunder shall be paid to the Seller's attorney who shall
hold the same in escrow subject to the terms and conditions hereof and release
same to Seller upon the satisfaction of all contingencies stated herein or
default by Purchaser, whichever shall first occur. Any other deposits held by
other parties shall immediately be forwarded to Seller's attorney to be held in
escrow under the same conditions. If there is a dispute as to the deposit the
escrow agent may commence an interpleader action and pay the deposit into court
whereupon the escrow agent shall be relieved of all further obligation.

Mortgage company checks or similar holding company checks, unless certified, DO
NOT represent immediate funds and will not be accepted at the time of closing.
Trustee checks are NOT satisfactory funds for any payment required by this
Agreement at the time of closing. In the event SELLER or his attorney accepts
PURCHASER's attorney's trustee check in lieu of other funds, PURCHASER and
PURCHASER's attorney agree that no stop payment order will be issued with
respect to such check(s)

4. Additional Down Payment/Contingencies.
   ----------------------------------------

     Upon execution of this Agreement or within ten (10) days thereafter, the
Seller will deliver to the Buyer such of the following documents as are in his
possession:

     (a) Survey of the property;
     (b) Wetland map or data in his possession;
     (c) A List of all Leases and the terms thereof;
     (d) Copies of all Leases

     The Purchaser shall expedituously perform all due diligence with respect to
the premises. Having done so, if within thirty (30) days of the date of the
contract the Purchaser determines to cancel and terminate this contract, he
shall then receive a refund of the aforesaid deposit upon delivery to Nevas,
Nevas, Capasse & Gerard, 246 Post Road East, P.O. Box 791, Westport, Connecticut
06881- 0791 notice of said cancellation in writing by delivery notice of such
cancellation within said 30 days.

     In the event the Purchaser does not cancel said contract as herein set
forth, then it shall forthwith pay to the Seller an additional sum of ONE
HUNDRED FIFTY-TWO THOUSAND FIVE HUNDRED and 00/100 ($152,500.00) DOLLARS. On the
expiration of said thirty (30) days after the decision of the Purchaser not to
terminate all sums paid hereunder shall be non-refundable.

     The Purchaser shall have one hundred eighty (180) days to obtain necessary
Branford Planning and Zoning Permits and Branford Wetlands Commission Permits
providing, however, that the Purchaser shall have diligently pursued such
applications and has filed said applications within sixty (60) days of the
execution of the contract.

     If the Purchaser diligently pursues such applications but there has not
been favorable action by the Planning and Zoning Commission and the Wetlands
Commission within said nine (9) month period, the Purchaser may, at his option,
extend the time for obtaining such permits for an additional

                                       -2-

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period of thirty (30) days upon payment of TWENTY-FIVE THOUSAND and 00/100
($25,000.00) DOLLARS. If, within the said thirty (30) days, the Purchaser
desires to extend the closing date for an additional thirty (30) days because of
the failure to obtain said permits, the Seller agrees that upon the payment of
an additional sum of TWENTY -FIVE THOUSAND and 00/100 ($25,000.00) DOLLARS the
closing date shall be extended for an additional thirty (30) days. The said
payments of FIFTY THOUSAND and 00/100 ($50,000.00) DOLLARS shall not be
refundable and shall not be credited on account of the purchase price.

5. Bond/Security Deposit.
   -----------------------

     The Seller has deposited with the Town of Branford a security deposit in
the amount of FIFTY EIGHT THOUSAND and 00/100 ($58,000.00) DOLLARS, which sum
shall be reimbursed by the Purchaser to the Seller at the time of closing. The
Seller shall assign to the Purchaser all rights and claims to the said bond.
Seller shall provide the Buyer with a copy of the bond and all supporting
documentation within ten (10) days of the date of the contract.

6. Adjustments, Prepaid Rents, Tax Reduction Proceedings.
   -------------------------------------------------------

     (a). The following items shall be adjusted between Seller and Purchaser as
of 12:01 a.m. of the Closing Date:

          (i). Real Estate, Personal Property and Other Municipally or State
               --------------------------------------------------------------
               Imposed Taxes.
               --------------
          Current real estate, personal property and other taxes, if any, which
are, or may become liens on the Property for the year of the closing shall be
assumed by Purchaser. Such taxes shall be adjusted pursuant to the custom
adopted by the Assessor of the Town of Branford and Guilford. If the assessment
or the tax rate shall not have been set as of the Closing Date, taxes shall be
assumed on the basis of the most recently ascertainable tax bill. When such
assessment or tax rate for the period covered by the assumption shall become
available, the Purchaser agrees to assume the increase in taxes associated
therewith, if any.

          (ii). Rents. The total rent potential for the calendar month during
which the closing shall take place, as set forth on the Leases delivered to
Purchaser at the closing whether or not all of such rents shall have been
received by Seller as of the Closing Date. All rental income attributable to a
period of time prior to the closing shall be payable to Seller and all rents
earned and attributable to any period after the closing shall be paid to
Purchaser. Seller specifically reserves the right to retain and/or proceed with
any and all claims for rentals attributable to its period of ownership. Any
payments received by Purchaser after closing, less any expenses of collection
incurred by Purchaser including reasonable attorney's fees, shall first be
applied to current rents due and the balance paid to Seller on account of any
rental arrearage shown on the Schedule of Leases attached hereto. Purchaser
shall not be obligated to bring suit to collect such arrearages. Rents prepaid
by tenants for any month subsequent to the month during which the closing shall
occur shall be credited to Purchaser by the Seller at the closing, or, if
received by Seller after the closing, shall be promptly remitted to Purchaser.

                                       -3-

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         (iii). Service and Other Contracts. Amounts, if any, prepaid or
                ----------------------------
accrued by Seller with respect to any service or other contracts assigned or
transferred to Purchaser at the closing, shall be credited to the Seller at the
time of the closing.

         (iv). Utilities. If any utility bills are presently in the name
               ----------
of the Seller, Seller shall use its best efforts to have utility meters read as
of the Closing Date and to cause utility companies to render final bills to
Seller, which bills Seller shall pay promptly. If a final bill shall not have
been rendered as of the Closing Date, the prepaid or unbilled, as the case may
be, amount of such utility shall be prorated on the basis of the most recently
ascertainable bill for such utility, and such utility shall be adjusted, if
necessary, when the actual bill therefore for the period covered by the
proration shall become available, and the appropriate credit or payment shall be
made between Seller and Purchaser upon demand of either party. For the purposes
of this paragraph "utilities" shall include but shall not be limited to
electricity, natural gas and fuel oil.

          (v). Water Hydrant and Sewer Use Charge. Purchaser shall assume
               ----------------------------------
all water, hydrant and sewer use charges at the time of closing with an
adjustment made between the Purchaser and Seller as to the prepaid or unbilled,
as the case may be. If the water, hydrant and sewer assessment or use charge
rate shall not have been set as of the Closing Date, said water, hydrant and
sewer use charges shall be assumed on the basis of the most recently
ascertainable bill for such water, hydrant and sewer use. Such water, hydrant
and sewer use charge shall be adjusted, if necessary, when the actual water,
hydrant and sewer use charge bills for the period shall become available, and
the appropriate credit or payment shall be made between Seller and Purchaser
upon demand of either party.

          (vi). Tenant Deposits. All amounts held by Seller as refundable
                ---------------
tenant deposits, and all interest thereon as, required by law under the leases
and tenancies shall be credited and assigned to Purchaser at the time of the
closing, which deposits may include, without limitation, security deposits, key
deposits or pet deposits. Purchaser herein agrees to assume all responsibility
from and after the Closing Date for such refundable tenant deposits and the
interest thereon upon receipt by Purchaser of an Assignment of Leases and
receipt or credit for the security deposits.

7. Final Inspection.
   ------------------

     The Purchaser shall have the right to make a final inspection of the
Property during the week preceding the closing and agrees to notify Seller of
the time and date of said final inspection at least twenty-four (24) hours prior
to the time and date of said final inspection.

8. Leases.
   --------

     Seller agrees to deliver to Purchaser copies of all leases, lease
extensions and lease modifications affecting the Property within ten (10) days
after receipt of a fully executed contract with the deposit required herein. In
the event any portion of the Property is subject to an oral or month to month
lease the Seller shall inform the Purchaser .of the circumstances of said oral
or month to month lease and agrees to set forth in writing the terms of such
occupancy and to deliver same to the Purchaser within said ten (10) days.

                                       -4-

<PAGE>

9. Title.
   ------

     (a). Purchaser, at its sole cost and expense shall promptly examine the
title to the Property and obtain current searches (a "UCC Search") of all
uniform Commercial Code financing statements filed with the Secretary of the
State of Connecticut against Seller and the Property, or either or them relating
to the Property. If Purchaser's examination of title to the Property discloses
any objection to title affecting marketability, or if Purchaser's UCC Search
reveals any claim or lien against Seller or the Property, Purchaser shall notify
Seller of any such objection within ten (10) days of receipt of its search. If
Seller, after making reasonable efforts to do so (including, without limitation,
the payment of money to obtain the release or discharge of liens or other
encumbrances securing the payment of money), shall be unable to remove or
correct any such title objection within ten (10) days prior to closing, Seller
shall so notify Purchaser, and Purchaser, at its option, may either (a) accept
such title as Seller can then convey without reduction of the Purchase Price or
any credit against the same or (b) terminate this Agreement, in which event
neither party shall have any further rights or obligations under this Agreement.

     (b). It is understood and agreed that the title herein required to be
conveyed by the Seller shall be marketable and the marketability thereof shall
be determined in accordance with the Standards of Title of the Connecticut Bar
Association now in force. It is also agreed that any and all defects in or
encumbrances against the title, which come within the scope of said Title
Standards, shall not constitute a valid objection on the part of the Purchaser,
if such Standards do not so provide; provided the Seller furnishes any
affidavits or other instruments which may be required by the applicable
Standards. If, at the time of closing, the Seller shall be unable to convey
marketable title to said Property to the Purchaser, then the Purchaser may elect
to accept such title as Seller can convey, upon payment of the Purchase Price,
or may reject the deed conveying such unmarketable title. Upon such rejection,
all sums paid as a Deposit shall be repaid to Purchaser without interest. Upon
such rejection, this Agreement shall terminate and become null and void and the
parties hereto shall be released and discharged of all further claims and
obligations to each other.

10. Closing; Closing Documents; Closing Costs.
    -------------------------------------------

     (a). The closing of title under this Agreement shall be held at the offices
of Snow, Atticks & Hollo, 69 Wall St. Madison, Connecticut. (The date on which
such closing of title shall take place is herein sometimes referred to as the
"Closing Date."). The terms "closing", "closing of title", "title closing",
"delivery of deed" and words of similar import are used interchangeably in this
Agreement, as the context may require, to mean the event of consummation of the
purchase and sale. The closing of title shall occur on the first of any of the
following days to occur:

          (i). Two hundred ten (210) days from the date of execution of this
Agreement;

          (ii). Thirty (30) days after obtaining permits from the Branford
Planning and Zoning Commission and the Branford Wetlands Commission;

          (iii). In the event the extensions as above set forth in paragraph 4
of this Agreement have been granted, then on the expiration of said extended
periods.

     (b). At the closing, Seller, at its sole cost and expense, shall, in
addition to any other documents required under this Agreement, deliver to
Purchaser, in form and content reasonably acceptable to counsel for Purchaser:

          (i). A Warranty Deed together with all conveyance taxes due in
connection with this transaction, conveying good and marketable fee simple title
to the Property, subject only to:

                                       -5-

<PAGE>

               (i) Any and all zoning and/or building restrictions, limitations,
regulations, ordinances, and/or laws; any and all building lines; and all other
restrictions, limitations, regulations, ordinances and/or laws imposed by any
governmental authority and any and all other provisions of any governmental
restrictions, limitations, regulations, ordinances and/or public and/or private
laws, provided same are not in violation at the time of closing.

               (ii) Real Property Taxes on the Current Grand List and any and
all existing tax payments, liens, and assessments, coming due on or after the
date of closing; the Purchaser shall by acceptance of the deed assume and agree
to pay, any and all tax payments, liens and assessments which may on or after
the date hereofbe assessed, levied against or become a lien on the Property.

               (iii) Any state of facts which a survey and/or physical
inspection of the Property might reveal, provided same do not render title
unmarketable (such exception shall not be included in the Warranty Deed, unless
it was in the legal description in the deed which Seller received upon
purchasing the property).

               (iv) Common law and/or other rights, if any, of upper and lower
riparian owners in and to any natural watercourse flowing through or adjoining
the Property, and all statutory and other rights of others in and to any such
watercourse.

               (v) Unless otherwise specifically agreed between the parties in
writing, any municipal assessment other than taxes such as sewers and the like
shall be paid on a current basis by the Seller and the balance assumed by the
Purchaser at closing.

               (vi) Such encumbrances as shown on Schedules A and B, if any.

          (ii). A Bill of Sale conveying the Personal Property of the Seller
located on the Property is in its "as is - where is" condition to Purchaser.

          (iii). An Affidavit of Seller dated as of the date of the closing (a)
verifying the non-existence of mechanic's and materialmen's lien rights (b)
verifying the non-existence of any tenants' rights, other than as set forth
herein, (c) verifying the non-existence of any security interests in persona
property and fixtures being sold with the property (d) affirming that Seller is
not a "foreign person" pursuant to Internal Revenue Code Section 1445; together
with any other affidavit reasonalby requested by the Purchasers' lender or title
company as to facts within Sellers' knowledge.

          (iv). A copy and a written assignment of each contract or service
contract pursuant to which any party shall be rendering services in connections
with the care, maintenance, upkeep or management of the Property. Purchaser
shall, at the closing, assume in writing, the obligations of Seller under all
such service contracts arising after the Closing Date unless such contracts are
terminable by Seller and Purchaser has elected not to assume said contracts.

          (v). All written leases, lease modifications and lease extensions and
a written assignment to Purchaser of all Seller's rights, title and interest in
and to all leases and tenancies, and in all and to all rentals thereafter
becoming due thereunder. Purchaser shall, at the closing, assume in writing the
obligations of Seller under all such leases and tenancies arising after the
Closing Date.

                                       -6-

<PAGE>

          (vi). All plans, surveys, (including site plans) and building
specifications pertaining to the Property which Seller possesses, or to which
Seller has reasonable access, shall be delivered within ten (10) days of this
Agreement, provided that Seller shall not be obligated to incur any cost or
expense in connection with providing same to the Purchaser.

          (vii). An assignment of all permits, licenses, contractual rights and
warranties affecting the Property.

          (viii). A copy of the Tenant Roll updated to the date of the closing
and certified by Seller as substantially complete and accurate.

     (c) At or prior to the closing, purchaser, at its sole cost and expense,
and, in addition to any other documents required under this Agreement, shall
deliver to Seller, in form and content reasonably acceptable to counsel for
Seller:

          (i). An Assumption Agreement of Seller's obligations under all leases,
lease modifications and lease extensions in effect at the time of the closing.

          (ii). An Assumption of Sellers' obligations under all service
contracts in effect at the time of the closing.

          (iii) Evidence of Purchaser's authority to enter into this Agreement,
to perform all of the obligations of the Purchaser as required by this
Agreement, to accept delivery of the deed to the Property and to execute such
other Agreements and instruments as shall be required pursuant to this
Agreement.

11. Occupancy and Possession: Grounds.
    -----------------------------------

     Purchaser shall have exclusive occupancy and possession of the Property on
the date of the closing subject to the rights of the tenants then in possession.
Seller agrees to deliver all keys in Seller's possession to the Purchaser on the
date of the closing. Seller agrees to maintain or have the grounds maintained in
reasonably the same condition as they exist on the date of execution of this
Agreement until the date of the closing.

12. Representations: Condition of Property
    ---------------------------------------

     Purchaser hereby acknowledges and represents that neither Seller nor any
person or party on behalf of Seller has made any representation of any nature
whatsoever upon which Purchaser has relied in entering into the Agreement or,
upon which Purchaser shall rely in consummating the transactions described in or
contemplated by this Agreement and that Purchaser shall accept delivery of title
to the Property in such condition as the Property shall be as of the date of
this Agreement. Purchaser further acknowledges and represents that it is
entering into this Agreement and shall perform all of its obligations hereunder
and consummate the transactions described in or contemplated by this Agreement
solely as a result of Purchaser's own inspections and investigations. The
Purchaser represents that the Purchaser has examined the Property and is
satisfied with the physical condition thereof and that neither Seller nor any
representative of Seller has made any representation or promise other than those
expressly stated herein upon which Purchaser has relied in making this
Agreement. Notwithstanding the foregoing, however, Seller hereby represents and
warrants to Purchaser as to the following matters, each of which is so warranted
to be true and correct as of the date hereof and only to the date hereof which
truth and correctness shall be a condition precedent to Purchaser's obligation
to close title and Seller agrees that it will not take any

                                       -7-

<PAGE>

action between the date hereof and the closing date which would result in any of
the foregoing representations becoming untrue in any material respect:

     (a). Seller is the owner of and has a good and marketable title to the
Property.

     (b). Seller has not entered into any other contract to sell or granted any
option or right of first refusal to purchase the Property, or any portion
thereof except to Purchaser.

     (c). The Property shall not be in violation of any ordinance, municipal
regulation, public or private law or restrictions at the time of the closing.

     (d). See Schedule B attached hereto.
              ----------

13. Risk of Loss.
    --------------

     The risk of loss or further damage to the Property by fire or any other
casualty or cause beyond the Seller's control in an amount independently
appraised at less than $2,000.00 or the taking of all or a portion of the
Property by Condemnation, eminent domain or other governmental acquisition
proceedings, in advance of the Closing Date shall be borne by Seller. In the
event of any damage, Seller shall have a reasonable time within which to repair
or replace such Damage. In the event of Seller's default of such repair or
replacement within a reasonable time, or in the event that any loss or further
damage to the Property exceeds the amount of $2,000.00 or that any such taking
by condemnation, eminent domain or other governmental acquisition proceeding, in
Purchaser's judgment, shall in any manner impair the Purchaser's intentions as
contemplated by this Agreement or the feasibility thereof as contemplated
herein, Purchaser shall have the right:

     (a). to terminate this Agreement and receive back all amounts paid as a
Deposit on the Purchase Price, plus interest thereon, in which event neither of
the parties hereto shall have any further rights or obligations hereunder; or

     (b). to accept the Property as provided in this Agreement without any
reduction of the Purchase Price, in which event Purchaser shall be entitled to
an assignment from Seller of all insurance proceeds or condemnation or other
award due or payable on account of such loss or damage or taking less any amount
actually expended by Seller in connection with the repair (including temporary
repair) or replacement of such damage plus the amount of any deductible, not to
exceed the amount of the loss.

14. Brokerage.
    -----------

     The parties hereto mutually warrant and represent that DOW REALTY CO. is
the sole broker who negotiated the sale of the Property and a commission or fee
shall be due as a result of this Agreement or the purchase contemplated hereby,
which commission shall be paid by the Seller. Seller covenants and agrees to
indemnify and hold Purchaser harmless of, from and against all claims, costs,
damages and expenses, including, without limitation, reasonable attorney's fees
and court costs, which Purchaser may suffer or incur as a result of claims made
or suits brought by any other broker, agent or for a commission based on
dealings or alleged dealings with Seller with respect to the purchase of the
Property. Purchaser agrees to indemnify and hold Seller harmless of, from and
against all claims, costs, damages and expenses, including, without limitation,
reasonable attorney's fees and court costs, which Seller may suffer or incur as
a result of claims made or suits brought by any broker, agent or finder except
as named herein for a commission based on dealings with Purchaser with respect
to the purchase of the Property.

                                       -8-

<PAGE>

15. Default: Liquidated Damages.
    -----------------------------

     In the event that the sale of the Property fails to close as a result of
any material act or omission on the part of the Purchaser and the Seller is not
in default, the Deposit shall be immediately paid over to the Seller by the
Seller's attorney on the date of the scheduled closing. Seller shall be entitled
to retain said Deposit as liquidated damages. The Seller and Purchaser hereby
agree that the exact extent of damages which the Seller would suffer as a result
of Purchaser's failure to close or as a result of Purchaser's act or omission or
default is incapable of being computed and therefore both the Seller and
Purchaser agree that the sum of the Deposit is the best available computation of
liquidated damages to which the Seller would be entitled. Upon the payment of
the Deposit to the Seller, both the Seller and Purchaser shall be relieved of
further liability under this Agreement.

16. Release of Mortgages:
    ----------------------

     Notwithstanding anything to the contrary contained in this Agreement or any
riders attached hereto, in the event the Seller after due diligence cannot
obtain a release for any existing mortgage on the Property at the time of the
closing of title from the lending institution holding said mortgage, or any
assignee thereof, either because said lending institution will not release the
mortgage without first receiving payment or because the lending institution has
delayed in sending the attorney for the Seller the release of mortgage, then
Purchaser agrees to close title notwithstanding the absence of the release of
mortgage, provided the attorney for the Seller furnishes the attorney for the
Purchaser, at the closing, with the payoff amount and a copy of the payoff check
evidencing that payment of the unreleased mortgage is to be made in full at the
time of the closing, and with an undertaking to make said payment, and further
provided the Purchaser's Title Insurance Company will issue a fee policy at no
additional premium which takes no exception for said mortgage or mortgages.
Seller shall exercise due diligence to obtain any such release or releases and
will upon receipt thereof immediately record the same and forward a copy or
copies thereof to Purchaser's attorney with recording information. If Seller has
not obtained such release within sixty (60) days after closing, he shall give to
Purchaser's attorney the affidavit provided for in Connecticut General Statutes
Section 49-8(a), as amended, together with the necessary recording fee. This
provision shall survive the closing.

17. Acceptance of Deed.
    --------------------

     The delivery and acceptance of the deed described herein shall be deemed to
constitute full compliance with all the tenDs, conditions, covenants and
representations contained herein, or made in connection with this transaction,
except as may herein be expressly provided and except for the warranties of
title.

18. Assignment
    -----------

     Purchaser may assign its rights under this Agreement without the written
consent of the other party.

19. Binding Effect.
    ----------------

This Agreement shall inure to the benefit of and bind the parties hereto and
their respective legal representatives, heirs, administrators, executors,
successors and assigns.

                                       -9-

<PAGE>
20. Merger: Amendment.
    ------------------

     This Agreement, and any Addendum annexed hereto, embodies the entire
contract between the parties hereto with respect to the Property and the subject
matter hereof and supersedes any and all prior negotiations agreements and
understanding, written or oral, formal or informal, all of which are deemed to
be merged herein. No modification or amendment to this Agreement of any kind
whatsoever shall be made or claimed by Seller or Purchaser, and no notice of any
extension, change, modification or amendment made or claimed by Seller or
Purchaser (except with respect to permitted unilateral waivers) shall have any
force or effect whatsoever unless the same is in writing and signed by both the
Seller and Purchaser.

21. Pronouns; Joint and Several Liability.
    ---------------------------------------

     All pronouns and nouns and any variations hereof shall be deemed to refer
to the masculine, feminine or neuter, singular or plural, as the identity of the
parties or the context may require. If Purchaser or Seller consists of two or
more parties, the liability of such parties shall be joint and several.

22. Invalidity.
    ------------

     If any term or provision of this Agreement shall to any extent or for any
reason be held invalid, illegal or unenforceable, such invalidity, illegality or
unenforceability shall not affect any other provision of this Agreement, but the
remainder of this Agreement and each term and provision of this Agreement shall
be valid and enforceable to the fullest extent permitted by law, subject to such
modification hereof as may be necessitated by such invalidity.

23. Application Law; Construction.
    -------------------------------

     (a). This Agreement and all questions of interpretation hereof and all
controversies hereunder, shall be construed in accordance with and governed by
the applicable procedural, statutory and common law of the State of Connecticut.

     (b). Neither this Agreement nor any term or provision of this Agreement
shall be construed against either party hereto by reason of such party's having
drafted, or caused to be drafted, either this Agreement or such term or
provision, as the case may be.

24. Notice.
    --------

     Any notice, demand, request or other communication made, given or required
pursuant to this Agreement shall be in writing and shall be sufficient if it is
(a) in writing, (b) delivered personally, deposited for delivery with a
commercial overnight courier or express service or mailed by certified or
registered first class mail, return receipt requested, postage prepaid, and (c)
addressed to the party for whom intended as follows:

     if to Sel1er:           Marc L. Nevas, Trustee for Bittersweet Associates
                             250 Post Road East
                             Westport, CT  06880

     copy to:                Leo Nevas, Esquire
                             Nevas, Nevas, Capasse & Gerard
                             246 Post Road East
                             Westport, CT 06880

                                      -10-

<PAGE>

     if to Purchaser:        Richard E. Beauvais
                             61 Soundview Road
                             P.O. Box 855
                             Guilford, CT 06437

     copy to:                Donald F. Snow, Jr., Esq.
                             Snow, Atticks & Hollo, LLC
                             69 Wall Street
                             Madison, CT 06443

     Either party may designate by notice given to the other a new address to
which notices or other communications intended for such party shall thereafter
be given. Unless otherwise stated in this Agreement, a notice or other
communication shall be deemed given on the earliest of when (a) actually
received, (b) personally delivered, (c) one day after being deposited with a
commercial overnight courier or express service or (d) two days after being
deposited in the United States mail in the manner aforesaid.

25. Calculation of Time.
    ---------------------

     Whenever in this Agreement a period of time is stated as a number of days,
it shall be construed to mean calendar days; provided, however, that when any
period of time so stated would end upon a Saturday, Sunday or legal holiday,
such period shall be deemed to end upon the next day following which is not a
Saturday, Sunday or legal holiday.

26. Expenses.
    ----------

     Whether or not the transactions contemplated under this Agreement are
consummated, Seller and Purchaser agree to pay their own expenses incident to
the preparation and performance of this Agreement, including, without
limitation, attorney's fees and costs.

27. Waivers: Extensions.
    ---------------------

     No waiver of any breach of any agreement or provision herein contained
shall be deemed a waiver of any preceding or succeeding breach thereof or of any
other agreement or provision herein contained. No extension of time for the
performance of any obligation or act shall be deemed an extension of the time
for the performance of any other obligation or act.

28. Survival.
    ----------

     This Agreement, and all of the covenants, conditions, representations,
warranties and other terms and provisions hereof shall merge into the deed to
the Property delivered to Purchaser at the closing.

29. Incorporation by Reference.
    ----------------------------

     All documents, instruments, schedules and other matters attached to this
Agreement as Exhibits are specifically made a part thereof and incorporated
herein by the reference thereto in the body of this Agreement.

                                      -11-

<PAGE>

30. Counterparts., Captions.
    -------------------------

     This Agreement may be executed in counterparts, each of which shall be
deemed to be an original. The captions are for convenience of reference only and
shall not affect the construction to be given any of the provisions hereof.

31. Recordation.
    -------------

     If this Agreement is recorded on the Branford and/or Guilford Land Records,
it shall automatically terminate within ten (10) days thereafter. Purchaser
agrees to execute and deliver a document in recordable form and acceptable to
Seller in form and substance sufficient to terminate the effect of this
Agreement and to release the encumbrance of the Agreement as a result of the
recordation of this Agreement. If Purchaser fails to do so, Purchaser shall be
liable to Seller for any damages from such failure as well as any and all costs
and expenses, including attorney's fees, incurred by Seller in obtaining such
termination or a judicial determination of such termination and the actual
release thereof.

     IN WITNESS WHEREOF, the parties have hereunto set their hands and seals.

                                     SELLER:

-----------------------------------  ------------------------------------------
Social Security Number               MARC L. NEVAS, TRUSTEE
                                     FOR BITTERSWEET ASSOCIATES

                                     PURCHASER:

-----------------------------------  ------------------------------------------
Social Security Number               RICHARD E. BEAUVAIS
                                                                        -

                                      -12-

<PAGE>

                                   SCHEDULE A
                                   ----------

     ALL THAT certain piece or parcel of land, together with the buildings
thereon, situated in the Towns of Branford and Guilford, County of New Haven and
State of Connecticut, bounded and described as follows:

NORTHWEST AND NORTH:      by the Boston Post Road, 501.17 feet, more or less;

EAST:                     by land now or formerly of Michael Harrison, et ux,
                          200 feet;

NORTH AGAIN:              by land now or formerly of Michael Harrison, et ux,
                          125 feet;

EAST AGAIN:               by land now or formerly of Norbert Kneuer Jr.,
                          243 feet, more or less;

NORTHEAST:                by land now or formerly of Norbert Kneuer, Jr.,
                          365 feet, more or less;

NORTHWEST AGAIN:          by land now or formerly of Norbert Kneuer, Jr.,
                          25 feet, more or less;

NORTHEAST AGAIN:          by land now or formerly of Kenneth R. Mattern et ux,
                          657.52 feet;

NORTHWEST AGAIN;          by land now or formerly of Kenneth R. Mattern et ux,
                          500 feet;

NORTHEAST AGAIN AND
EAST AGAIN:               by Orchard Road, formerly known as Goldsmith Road,
                          1450 feet, more or less;

SOUTH:                    by land now or formerly of Henry G. Goldsmith,
                          375 feet, more or less;

EAST AGAIN:               by land now or formerly of Henry G. Goldsmith,
                          550 feet, more or less;

SOUTH AGAIN:              by land now or formerly of Henry G. Cooke and now or
                          formerly of the Estate of Charles W. Cooke, 1960 feet,
                          more or less;

NORTHWEST AGAIN:          by land now or formerly of John P. Riesman et ux,
                          208.37 feet;

WEST:                     by land now or formerly of John P. Riesman et ux,
                          39.72 feet;

<PAGE>

                              SCHEDULE A CONTINUED
                              --------------------

NORTHWEST AGAIN:          by land now or formerly of John P. Riesman et ux,
                          120.48 feet;

SOUTHWEST:                by land now or formerly of John P. Riesman et ux,
                          225 feet;

WEST AGAIN:               by land formerly of Sidney Harris and Kalman Liske,
                          more lately now or formerly of Matteo H. Leona, Jr.
                          and Carl C. Leona 1426.80 feet, more or less, by a
                          broken line;

NORTH AGAIN:              by land now or formerly of Frederick A. Dudley et ux,
                          136.61 feet;

WEST AGAIN:               by land now or formerly of Frederick A. Dudley et ux,
                          300 feet.

     SAID premises are shown on a map entitled "Property of Robert and Jane W.
Wallace Boston Post Road, Branford and Guilford Connecticut May 1956 - Scale 1"
= 100'" certified substantially correct by Robert H. Decker, registered engineer
and land surveyor, which map is on file in the Branford Town Clerk's Office.

     EXCEPTING THEREFROM, HOWEVER, THE FOLLOWING DESCRIBED PARCELS:

     1) .23 acre, more or less, situated on the southeasterly side of the Boston
Post Road, as conveyed by Robert Wallace and Jane W. Wallace to the State of
Connecticut by deed dated May 14, 1956 and recorded in Volume 154, Page 39 of
the Branford Land Records;

     2) lots situated on the westerly side of Orchard Road, formerly known as
Goldsmith Road, as conveyed by Robert Wallace and Jane W. Wallace by four deeds
recorded in the Guilford Land Records as follows:

                  a) deed dated January 31, 1977 - Volume 229, Page 686;
                  b) deed dated February 1, 1977 - Volume 229, Page 840;
                  c) deed dated April 26, 1977 - Volume 231, Page 142;
and
                  d) deed dated May 31, 1977 - Volume 231, Page 994.

<PAGE>

                                   SCHEDULE B

1. Any and all provisions of any zoning, planning or other ordinance, municipal
regulation or public law.

2. The Purchaser assumes and agrees to pay all taxes and assessments payable
after the closing of title and the Buyer shall reimburse the Seller for all
prepaid taxes or assessments.

3. Any riparian, drainage or littoral rights of others in and to any water or
body of water adjoining or passing through the above premises.

4. Any and all assessments which may on or after the date hereof be assessed,
levied or imposed against or become a lien upon the premises or any part
thereof.

5. Any state of facts which a physical inspection or accurate survey of the
premises might disclose, provided that such survey does not disclose a violation
of the applicable zoning regulations or render the title otherwise unmarketable.

6. An easement to the Connecticut Light and Power Compay dated November 29, 1972
and recorded in Volume 249 at Page 711 of the Branford Land Records.

7. An Assessor's Certificate filed under Public Act 490, from Robert Wallace to
the Town of Branford for Farm Acreage, recorded April 9, 1974 in Volume 260 at
Page 449 of said Land Records.

8. An Assessor's Certificate filed under Public Act 490, from Robert and Jane W.
Wallace to the Town of Guilford dated November 24, 1975 and recorded in Volume
219 at Page 587 of the Guilford Land Records.

9. Notices from the Planning and Zoning Commission and the Zoning Board of
Appeals of the Town of Branford, as recorded in Volume 285 at Page 125, Volume
289 at Page 609, Volume 290 at Page 784 and Volume 294 at Page 691 of the
Branford Land Records.

10. Rights of tenants in possession.<PAGE>

                                                                   EXHIBIT 10.30

     THIS EMPLOYMENT AGREEMENT ("Agreement") is made and entered into as of
March 4, 2002 between CuraGen Corporation, a corporation organized under the
laws of the State of Delaware, with its principal place of business at 555 Long
Wharf Drive, New Haven, Connecticut (the "Company"), and Jonathan M. Rothberg
("Executive").

     WHEREAS, the Executive desires to be employed by the Company, subject to
the terms and conditions of this Agreement; and the Company desires to retain
the Executive's services, subject to the terms and conditions of this Agreement.

     THEREFORE, the Company and the Executive, intending to be legally bound,
hereby agree as follows:

1. Employment; Duties and Responsibilities
   ---------------------------------------

     A) The Company shall employ the Executive, and the Executive shall serve
the Company, as Chairman, President and Chief Executive Officer, with such
duties and responsibilities as may be assigned to the Executive by the Board of
Directors ("BOD") of the Company and are typically associated with a position of
that nature.

     B) The Executive shall devote his best efforts and all of his business time
to the performance of his duties under this Agreement and shall perform them
faithfully, diligently and competently in a manner consistent with the policies
and goals of the Company as determined from time to time by the BOD.

     C) The Executive shall report to the BOD of the Company.

     D) The Executive shall not engage in any activities outside the scope of
his employment that would detract from, or interfere with, the fulfillment of
his responsibilities or duties under this Agreement.

                                       1

<PAGE>

     E) The Executive shall not serve as a director (or the equivalent position)
of any company or entity and shall not render services of a business,
professional or commercial nature to any other person or firm without prior
written consent of the BOD. Such consent shall not be unreasonably withheld.

     F) The Executive shall not receive fees or other remuneration for work
performed either within or outside the scope of his employment except for
not-for-profit entities without prior written consent of the BOD. Such consent
shall not be unreasonably withheld.

2. Term of Employment
   ------------------

     A) The Executive's employment by the Company under this Agreement shall
commence on the date of this Agreement and, subject to the earlier termination
pursuant to section 10 shall terminate on December 31, 2002; provided, however,
that commencing on January 1, 2003 and each January 1 thereafter the term of
this Agreement shall be extended for one (1) additional year unless, not later
than October 31 of the preceding year, the Company or the Executive shall have
given written notice that the Company or the Executive does not wish to extend
this Agreement.

                                       2

<PAGE>

3. Compensation
   ------------

     As full compensation for all services rendered by the Executive to the
Company under this Agreement, the Company shall pay the Executive the
compensation set forth in Schedule A attached and incorporated into this
Agreement. This schedule may be amended from time to time in writing by the
Company and the Executive.

4. Fringe Benefits
   ---------------

     A) The Executive shall be entitled to participate in all health and welfare
benefit plans provided by the Company to its employees.

     B) The Executive shall be entitled to participate in all pension plans
provided by the Company to its employees.

     C) The Company may, at its sole option, devise a benefit plan for its
executives or senior managers. The Executive shall be entitled to participate in
benefit plans provided by the Company to its executives or senior managers.

     D) The Executive shall be entitled to a minimum of four (4) weeks paid
vacation time annually, to be taken at times selected by him.

5. Expenses
   --------

     The Company shall reimburse the Executive for all reasonable
and necessary expenses incurred by him in connection with the performance of his
services for the Company in accordance with the Company's policies, upon
submission of appropriate expense reports and documentation in accordance with
the Company's policies and procedures.

                                       3

<PAGE>

6. Disability or Death
   -------------------

     A) If, as the result of any physical or mental disability, the Executive
shall have failed or is unable to perform his duties for a period of ninety (90)
consecutive days, the Company may, by notice to the Executive, terminate his
employment under this Agreement as of the date of the notice without any further
payment or the furnishing of any benefit by the Company under this Agreement
(other than accrued and unpaid base salary and expenses and benefits which have
accrued pursuant to any plan or by law).

     B) The term of the Executive's employment under this Agreement shall
terminate upon his death without any further payment or the furnishing of any
benefit by the Company under this Agreement (other than accrued and unpaid base
salary and commission and expenses and benefits which have accrued pursuant to
any plan or by law). This provision shall not be read to change the terms of any
other agreement between the Executive and the Company, including any stock
option plans, which shall be governed by its terms. Unless expressly provided
for in such agreements, the death of the Executive shall not terminate such
agreements.

7. Patents, Copyrights and Intellectual Property
   ---------------------------------------------

     A) The Executive shall promptly disclose to the Company all Inventions.
Inventions shall mean, for purposes of this paragraph, inventions, discoveries,
developments, methods and processes (whether or not patenable or copyrightable
or constituting trade secrets) conceived, made or discovered by the Executive
(whether alone or with others) while employed by the Company that relate,
directly or indirectly, to the past, present, or future business activities,
research, product design or development, personnel, and business opportunities
of the Company, or result from tasks assigned to the Executive by the Company or
done by the Executive for or on behalf of the Company. The Executive hereby
assigns and agrees to assign to the Company

                                       4

<PAGE>

(or as otherwise directed by the Company) his full right, title and interest in
and to all Inventions. The Executive agrees to execute any and all applications
for domestic and foreign patents, copyrights or other proprietary rights and to
do such other acts (including, among others, the execution and delivery of
instruments of further assurance or confirmation) requested by the Company to
assign the Inventions to the Company and to permit the Company to file, obtain
and enforce any patents, copyrights or other proprietary rights in the
Inventions. The Executive agrees to make and maintain adequate and current
records of all Inventions, in the form of notes, sketches, drawings, or reports
relating thereto, which records shall be and remain the property of and
available to the Company at all times.

                                       5

<PAGE>

8. Proprietary and Trade Secret Information
   ----------------------------------------

     A) The Executive agrees that he will keep confidential and will not make
any unauthorized use or disclosure, or use for his own benefit or the benefit of
others, during or subsequent to his employment of any research, development,
engineering and manufacturing data, plans, designs, formulae, processes,
specifications, techniques, trade secrets, financial information, customer or
supplier lists or other information that becomes known to him as a result of his
employment with the Company which is the property of the Company or any of its
clients, customers, consultants, licensors, licensees, or affiliates, provided
nothing herein shall be construed to prevent the Executive from using his
general knowledge and skill after termination of his employment whether acquired
prior to or during his employment by the Company.

     B) Proprietary information subject to paragraph 8(A) does not include
information that: (i) is or later becomes available to the public through no
breach of this Agreement by the Employee; (ii) is obtained by the Executive from
a third party who had the legal right to disclose the information to the
Executive; or (iii) is required to be disclosed by law, government regulation,
or court order.

                                       6

<PAGE>

     C) Upon leaving the employment of the Company, the Executive will not
remove from the Company premises, either directly or indirectly, any drawings,
writings, prints, any documents or anything containing, embodying, or disclosing
any confidential or proprietary information or any of the Company's trade
secrets unless express written permission is given by the Board of Directors.
Upon termination of his employment, the Executive shall return to the Company
any and all documents and materials that are the property of the Company or its
customers, licensees, licensors or affiliates or which contain information that
is the property of the Company.

9. Covenant Not to Compete
   -----------------------

     A) While in the employ of the Company and for a period of one year or the
maximum period permitted by applicable law (whichever is shorter) following
termination of his employment with the Company, the Executive shall not, without
the approval of the Company, alone or as a partner, officer, director,
consultant, employee, stockholder or otherwise, engage in any employment,
consulting or business activity or occupation that is or is intended to be
directly competitive with the business of the Company, as being considered,
researched, developed, marketed and/or sold at the time of termination;
provided, however, that the holding by the Executive of any investment in any
security shall not be deemed to be a violation of this section if such
investment does not constitute over one percent (1%) of the outstanding issue of
such security. The restriction shall run for a period of one year after said
termination, and if there shall be any violation hereof during said period, then
for a period of one year after cessation of such violation.

     B) While in the employ of the Company, the Executive shall promptly notify
the Company, if the Executive, alone or as a partner, officer, director,
consultant, employee,

                                       7

<PAGE>

stockholder or otherwise, engages in any employment, consulting or business
activity or occupation outside his employment by the Company.

     C) The Executive shall not, directly or indirectly, either during the term
of the Executive's employment under this Agreement or for a period of one (1)
year thereafter, solicit, directly or indirectly, the services of any person who
was a full-time employee of the Company, its subsidiaries, divisions or
affiliates, or solicit the business of any person who was a client or customer
of the Company, its subsidiaries, divisions or affiliates, in each case at any
time during the last year of the term of the Executive's employment under this
Agreement. The Executive shall not, directly or indirectly, either during the
term of the Executive's employment under this Agreement or for a period of one
(1) year thereafter, employ, directly or indirectly, the services of any person
who was a full-time employee of the Company, its subsidiaries, divisions or
affiliates, or solicit the business of any person who was a client or customer
of the Company, its subsidiaries, divisions or affiliates, in each case at any
time during the last year of the term of the Executive's employment under this
Agreement. For purposes of this Agreement, the term "person" shall include
natural persons, corporations, business trusts, associations, sole
proprietorships, unincorporated organizations, partnerships, joint ventures and
governments or any agencies, instrumentalities or political subdivisions
thereof.

     D) The Executive acknowledges and agrees that the covenants in this section
are necessary for the protection of the legitimate business interests of the
Company and that the covenants are reasonable in all respects. The Executive
further acknowledges and agrees that, if his employment by the Company is
terminated, his experience and capabilities are such that he is both qualified
and willing to seek and obtain employment involving business activities which

                                       8

<PAGE>

will not violate any covenant on his part to be observed hereunder and that a
court decree enjoining any such violation will not prevent him from earning a
reasonable livelihood.

     E) Just compensation for the duties under this paragraph is included in the
salary and benefits provided herein.

     F) If the Executive is terminated as a result of a Change of Control, as
defined in this Agreement, this Section, titled "Covenant Not to Compete," shall
not be applicable.

10. Termination
    -----------

     A) The Company shall have the right to terminate this Agreement and the
Executive's employment with the Company for performance reasons or cause. For
purposes of this Agreement, the term "performance reasons" shall mean
termination of the Executive's employment upon the assessment of the Board of
Directors, or a Committee of the Board of Directors, that the Executive has
failed to satisfactorily perform the essential functions of the Executive's
position. Such a determination shall be made using acceptable business practices
and sound management principles and shall not be made in bad faith or
arbitrarily.

     B) For purposes of this Agreement, the term "for cause" shall mean the
Executive's willfully engaging in conduct demonstrably and materially injurious
to the Company, monetarily or otherwise, provided that the Executive receives a
copy of a resolution duly adopted by the unanimous affirmative vote of the
entire membership of the Board of Directors of the Company at a meeting of the
Board of the Company called and held for such purpose after the Executive has
been given reasonable notice of such meeting and has been given an opportunity,
together with his counsel, to be heard by the Board of the Company, finding that
in the good faith opinion of the Board of the Company the Executive was guilty
of the conduct set forth and specifying the particulars thereof in detail.

                                       9

<PAGE>

     C) The Executive's act, or failure to act, shall be deemed "willful" if the
Executive was not acting in good faith or acting without reasonable belief that
the Executive's action or omission was in the best interests of the Company. Any
act or failure to act based on authority given pursuant to a resolution duly
adopted by the Board of the Company, or based upon the advice of counsel for the
Company shall be conclusively presumed to have been done by the Executive in
good faith and in the best interests of the Company.

     D) If the Executive is terminated for cause, the Company shall not be
obligated to make any further payment to the Executive (other than accrued and
unpaid base salary and expenses to the date of termination), or continue to
provide any benefit (other than benefits which have accrued pursuant to any plan
or by law) to the Executive under this Agreement.

         E) If the Executive is terminated for performance reasons, the
Executive shall be entitled to certain benefits. The benefits shall consist of
(i) salary continuation at the salary the Executive was receiving at the time of
termination and (ii) the Executive's continued participation in any employee
health and welfare benefit plan to which the Executive was a participant prior
to his termination on the same basis as the Executive had participated as an
employee. The salary continuation and continued participation in any health and
welfare benefit plan shall be for twelve (12) months.

11. Change of Control
    -----------------

     A) "Change in Control" of CuraGen Corporation means the occurrence of any
        -------------------
one of the following events:

          (i) individuals who, on January 1, 2002, constituted the Board (the
     "Incumbent Directors") cease for any reason to constitute at least a
     majority of the Board, provided that any person becoming a director
     subsequent to January 1, 2002,

                                       10

<PAGE>

     whose election or nomination for election was approved by a vote of at
     least two-thirds of the Incumbent Directors then on the Board (either by a
     specific vote or by approval of the proxy statement of the Company in which
     such person is named as a nominee for director, without objection to such
     nomination) shall be an Incumbent Director; provided, however, that no
     individual elected or nominated as a director of the Company initially as a
     result of an actual or threatened election contest with respect to
     directors or any other actual or threatened solicitation of proxies (or
     consents) by or on behalf of any person other than the Board shall be
     deemed an Incumbent Director;

          (ii) any "person" (as such term is defined in Section 3(a)(9) of the
     Securities Exchange Act of 1934 [the "Exchange Act"] and as used in Section
     13(d)(3) and 14(d)(2) of the Exchange Act) is or becomes a "beneficial
     owner" (as defined in Rule 13d-3 under the Exchange Act), directly or
     indirectly, of securities of the Company representing 25% or more of the
     combined voting power of the Company's then outstanding securities eligible
     to vote for the election of the Board (the "Company Voting Securities");
     provided, however, that the event described in this paragraph (ii) shall
     not be deemed to be a Change in Control by virtue of any of the following
     acquisitions: (A) by the Company or any Subsidiary; (B) by any employee
     benefit plan sponsored or maintained by the Company or Subsidiary; or (C)
     by any underwriter temporarily holding securities pursuant to an offering
     of such securities;

                                       11

<PAGE>

          (iii) the consummation of a merger, consolidation, statutory share
     exchange or similar form of corporate transaction involving the Company or
     any of its Subsidiaries that requires the approval of the Company's
     stockholders, whether for such transaction or the issuance of securities in
     the transaction (a "Business Combination"), unless immediately following
     such Business Combination: (A) more than 50% of the total voting power of
     (x) the corporation resulting from such Business Combination (the
     "Surviving Corporation"), or (y) if applicable, the ultimate parent
     corporation that directly or indirectly has beneficial ownership of 100% of
     the voting securities eligible to elect directors of the Surviving
     Corporation (the "Parent Corporation"), is represented by Company Voting
     Securities that were outstanding immediately prior to such Business
     Combination (or, if applicable, shares into which such Company Voting
     Securities were converted pursuant to such Business Combination), and such
     voting power among the holders thereof is in substantially the same
     proportion as the voting power of such Company Voting Securities among the
     holders thereof immediately prior to the Business Combination; (B) no
     person (other than any employee benefit plan sponsored or maintained by the
     Surviving Corporation or the Parent Corporation), is or becomes the
     beneficial owner, directly or indirectly, of 20% or more of the total
     voting power of the outstanding voting securities eligible to elect
     directors of the Parent Corporation (or, if there is no Parent Corporation,
     the Surviving Corporation); (C); at least a majority of the members of the
     board of directors of the Parent Corporation (or, if there is no Parent
     Corporation, the Surviving Corporation) were incumbent Directors at the
     time of the Board's approval of the execution of the initial agreement
     providing for such Business Combination (any Business Combination which
     satisfies all of the criteria specified in (A), (B) and (C) above shall be
     deemed to be a "Non-Qualifying Transaction"); or

          (iv) the stockholders of the Company approve a plan of complete
     liquidation or dissolution of the Company or a sale or disposition of all
     or substantially all of the Company's assets.

     B) Notwithstanding the foregoing, a Change in Control of the Company shall
not be deemed to occur solely because any person acquires beneficial ownership
of more than 25% of the Company Voting Securities as a result of the acquisition
of Company Voting Securities by the Company which reduces the number of Company
Voting Securities outstanding.

12. Benefits Upon Termination

    -------------------------

     A) If the Executive is terminated by the Company for any reason other than
for cause, performance reasons, retirement, total disability or death, or if
this Agreement is not renewed by the Company, pursuant to Section 2.A., the
Executive shall be entitled certain benefits. The benefits shall consist of (i)
salary continuation at the salary the Executive was receiving at the time of
termination and (ii) the Executive's continued participation in any employee
health and welfare benefit plan to which the Executive was a participant prior
to his termination on the same basis as the Executive had participated as an
employee. The salary

                                       12

<PAGE>

continuation and continued participation in any health and welfare benefit plan
shall be for twelve (12) months.

     B) However, if the Executive is terminated by the Company within twelve
(12) months of a Change of Control as defined in this Agreement, the Executive
shall be entitled to an additional twelve (12) months of salary continuation and
continued participation in any health and welfare benefit plan for a total of
twenty-four (24) months salary continuation and participation in the health and
welfare benefit plan.

     C) If the Executive terminates his employment for a "good reason," the
Executive shall be entitled to the same benefits as provided in paragraph B of
this section. Termination by the Executive of his employment for "good reason"
shall mean termination based on:

          (i) subsequent to a Change in Control of the Company, and without the
     Executive's express written consent, any reduction in Executive's duties or
     responsibilities compared to those prior to a Change in Control, or a
     change in the Executive's reporting responsibilities, titles or offices as
     in effect immediately prior to a Change in Control, or any removal of the
     Executive from, or any failure to re-elect the Executive, to any of his
     previously held positions with the Company; except in connection with the
     termination of the Executive's employment for Cause, Disability or
     Retirement or as a result of the Executive's death or by the Executive
     other than for good reason;

          (ii) subsequent to a Change in Control of the Company, a reduction by
     the Company in the Executive's base salary as in effect on the date hereof
     or as the same may be increased from time to time;

          (iii) subsequent to a Change in Control of the Company, a failure by
     the Company to continue any bonus plans in which the Executive is presently
     entitled

                                       13

<PAGE>

     to participate (the "Bonus Plans") as the same may be modified from time to
     time but substantially in the form currently in effect, or a failure by the
     Company to continue the Executive as a participant in the Bonus Plans on at
     least the same basis as the Executive presently participates in accordance
     with the Bonus Plans;

          (iv) subsequent to a Change in Control of the Company and without the
     Executive's express written consent, the Company's requiring the Executive
     to be based anywhere other than within fifty (50) miles of the Executive's
     present office location, except for required travel on the Company's
     business to an extent substantially consistent with the Executive's present
     business travel obligations;

          (v) subsequent to a Change in Control of the Company, the failure by
     the Company to continue in effect any benefit or compensation plan, stock
     ownership plan, stock purchase plan, stock option plan, life insurance
     plan, health-and-accident plan or disability plan in which the Executive is
     participating at the time of a Change in Control of the Company (or plans
     providing the Executive with substantially similar benefits), the taking of
     any action by the Company which would adversely affect the Executive's
     participation in or materially reduce the Executive's benefits under any of
     such plans or deprive the Executive of any material fringe benefit enjoyed
     by the Executive at the time of the Change in Control, or the failure by
     the Company to provide the Executive with the number of paid vacation days
     to which the Executive is then entitled in accordance with the Company's
     normal vacation policy in effect on the date hereof; or

                                       14

<PAGE>

          (vi) subsequent to a Change in Control of the Company, any purported
     termination of the Executive's employment which is not effected pursuant to
     the terms of this Agreement. No such purported termination shall be
     effective.

     D) Upon a Change of Control, notwithstanding any other agreement, all
stock, restricted stock, stock options or restricted stock options of the
Executive shall become fully vested to 100%.

13. Arbitration
    -----------

     A) Any dispute under this Agreement, including any dispute as to cause or
good reason for termination, shall be submitted to binding arbitration subject
to the rules of the American Arbitration Association. EACH OF THE PARTIES
IRREVOCABLY AND UNCONDITIONALLY WAIVES THE RIGHT TO A TRIAL BY JURY IN ANY SUCH
ACTIONS, SUIT OR PROCEEDING. The Company shall bear all costs associated with
the Arbitration, including filing fees and any stipend for the arbitrator. The
Company and the Executive shall each bear its own attorneys' fees. However, if
the Executive prevails in a challenge to the Company's determination for cause,
the Executive shall be entitled to be reimbursed for all attorney fees.

     B) Nothing in this section shall be read to preclude the Company seeking
injunctive relief for the Executive's breach of Section 8, Proprietary and Trade
Secret Information or Section 9, Covenant Not to Compete.

                                       15

<PAGE>

14. Injunctive Relief
    -----------------

     A) The Executive acknowledges that the services rendered by him under this
Agreement are of a special, unique and extraordinary character and, in
connection with such services, he will have access to confidential information
concerning the Company's business. By reason of this access to confidential
information, the Executive consents and agrees that if he violates any of the
provisions of this Agreement with respect to Proprietary and Trade Secret
Information or the Covenant Not to Compete, the Company would sustain
irreparable harm and, therefore, in addition to any other remedies which the
Company may have under this Agreement or otherwise, the Company shall be
entitled to an injunction to be issued by any court of competent jurisdiction
restraining the Executive from committing or continuing to commit any such
violation of this Agreement.

15. Miscellaneous
    -------------

     A) This Agreement shall be governed by and construed in accordance with the
laws of the State of Connecticut, applicable to agreements made and to be
performed in Connecticut, and shall be construed without regard to any
presumption or other rule requiring construction against the party causing the
Agreement to be drafted.

     B) This Agreement contains a complete statement of all the arrangements
between the Company and the Executive with respect to its subject matter,
supersedes all previous agreements, written or oral, among them relating to its
subject matter and cannot be modified, amended or terminated orally. Amendments
may be made to this Agreement at any time if mutually agreed upon in writing.

     C) Any amendment, notice or other communication under this Agreement shall
be in writing and shall be considered given when received and shall be delivered
personally or mailed

                                       16

<PAGE>

by Certified Mail, Return Receipt Requested, to the parties at their respective
addresses set forth in this Agreement, or at such other address as a party may
specify by written notice to the other.

     D) The failure of a party to insist upon strict adherence to any term of
this Agreement on any occasion shall not be considered a waiver or deprive that
party of the right thereafter to insist upon strict adherence to that term or
any other term of this Agreement. Any waiver must be in writing.

     E) Each of the parties irrevocably submits to the exclusive jurisdiction of
any court of the State of Connecticut or the Federal District Court of
Connecticut over any action, suit or proceeding relating to or arising out of
this Agreement and the transactions contemplated hereby. Each party hereby
irrevocably waives any objections, including, without limitation, any objection
to the laying of venue or based on the grounds of forum non conveniens which
such party may now or hereafter have to the bringing of any such actions, suit
or proceeding in any such court and irrevocably agrees that process in any such
actions, suit or proceeding may be served upon that party personally or by
Certified or Registered Mail, Return Receipt Requested.

     F) The invalidity or unenforceability of any term or provision of this
Agreement shall not affect the validity or enforceability of the remaining terms
or provisions of this Agreement which shall remain in full force and effect and
any such invalid or unenforceable term or provision shall be given full effect
as is legally permissible. If any term or provision of this Agreement is invalid
or unenforceable in one jurisdiction, it shall not affect the validity or
enforceability of that term or provision in any other jurisdiction.

     G) This Agreement is not assignable by either party except that it shall
inure to the benefit of and be binding upon any successor to the Company by
merger or consolidation or the acquisition of all or substantially all of the
Company's assets, provided such successor assumes

                                       17

<PAGE>

all of the obligations of the Company, and shall inure to the benefit of the
heirs and legal representatives of the Executive.

By: /s/ Robert E. Patricelli                    4-1-02
    ----------------------------------          ------
    Robert E. Patricelli                         Date
    Chairman, Compensation Committee
    Board of Directors
    CuraGen Corporation
    555 Long Wharf Drive 11th Floor
    New Haven, CT 06511

By: /s/ Jonathan M. Rothberg                    4-1-02
    -------------------------------             ------
    Jonathan M. Rothberg                         Date
    Chief Executive Officer
    CuraGen Corporation
    555 Long Wharf Drive 11th Floor
    New Haven, CT 06511
    ("the Executive")

                                       18

<PAGE>

                                   SCHEDULE A

     Compensation

     The Executive shall receive the following compensation for services during
the initial term of employment:

                   1) The Executive's base salary shall be $363,700 per year,
                      payable in bi-weekly installments, subject to increases by
                      the Board of Directors, which shall review the salary
                      periodically.

                   2) The Executive, if otherwise eligible, shall participate in
                      any incentive compensation plan, pension, profit sharing,
                      stock purchase or stock option plan, annuity, or group
                      insurance plan, medical plan and other benefits,
                      maintained by the Company for its employees.

                   3) The Executive shall be eligible to receive performance-
                      based bonuses on the attainment of certain goals set by
                      the Compensation Committee of the Board of Directors.

                                       19

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