Document:

eworld_ex1011.htm

EXHIBIT 10.11

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

	
OPCSpa

 

A. OPCSpa Characteristics

 

1. Made from Oligomeric Proanthocyanidins (OPC), 100% herbal extracts;

2. 20 times more efficient than Vitamin C and 60 times more efficient than Vitamin E;

3. Small molecule structure fights the lipid oxidation of cell membranes;

4. Helps fight oxidation and free radicals;

5. Strengthens the human immune system and cell metabolism against cell mutation;

 

B.OPCSpa Ingredients

 

Oligomeric Proanthocyanidins (OPCs),Lycopene, Grape Seed Extract, Pycogenol, Green Tea Polyphenols(GTP), Red Wine Extract, HPM (Veg- giecap) , 500mg / capsule.

 

C.OPCSpa Functions and Effects

 

As a natural nutrition substance, the product has the following functions:

● Improves the resistance and functions of mi- cro-vessels;

● Improves the resistance of the immune sys- tem;

● Improves the recycling operation of the retina and improves sight;

● Mollifies adverse reactions to inflammations;

● Slows down the aging process and loss of elasticity process of the skin;

● Participates in the prevention of cancer, allergy, aging, inflammation and ulceration.

 

D. Helpful for the following symptoms

 

Helps with allergic illnesses, cancer, aging, wrin- kled skin, persistent prostatitis, prostate hyper- trophy,  arthritis,  cataract,  heart  diseases,  se- nile dementia, hypertension, arteriosclerosis, gastric ulcer, athletes trauma, poor immunity, cataract,macular degeneration, nyctalopia, retina

 

 

 

 

 

 

 

 

 

 

 

	 	

 

diseases, varicosity; vessel diseases, scurvy and urinary system inflammation in chronic diabetes patients, kidney stone and arteriosclerosis.

 

Target group: students, teachers, computer work- ers, banking staff, drivers, pilots, policemen and computer game fans.

 

E. Dosage

 

General dosage: 1-2 capsules each time, two times per day

Intensive dosage: 2-3 capsules each time, three times per day

It has no side effects even after long-term admin- istration. Can be taken during meals.

 

Understanding the Anti-oxidation Effect of OPCSpa

 

OPCSpa consists of Pycnogenol and 95% original anthocyanin, which is the most effective antioxi- dant for human cell metabolism and in removing free radicals.  It can be absorbed quickly in the human body.  Researches proved that 80% of the diseases are caused by excessive amount of free radicals, such as allergy and allergic asthma.  Be- ing a difficult problem in modern medical science,

	 	 	 

 

  

1

  

 

Bio-tech Micro Molecules Nutrition Supplement  生物高科技-細胞小分子營養食品

 

	allergy is troubling many patients. Out of 50 years study, scientists from Europe and America found that the cause to allergy is free radicals, which crack up mast cells and alkali cells, and release genes that cause allergy.  Below is an analysis to the ingredients and effects of OPCSpa: 

 

A.Effects of Oligomeric Proanthocyanidins (OPCs) : 

 

Oligomeric  Proanthocyanidins sight-improving and anti-oxidation capsule is a powerful antioxidant, and is helpful for heart diseases, hardened blood vessels, cancer, glaucoma, cataract, venous tumor, diabetes, and nyctalopia.  It is a perennial shrub that grew originally in North Europe, North America and Canada.  The blackish purple color- ed fruit of Oligomeric Proanthocyanidins, which is often called the “blueberry of Europe,” is easily confused with the blueberry from American.

 

Research showed that Oligomeric Proanthocyani- dins has a more valuable effective ingredient than the blueberry, i.e. the anthocyanin.  It is because of this reason that the former is extensively used to treat nyctalopia and sight improvement, rather than be made into jam or food materials as the blueberry. The market price of genuine Oligomeric Proanthocyanidins is 25 times the price of its likes. Many anti-oxidation products on the market claim to contain  Oligomeric  Proanthocyanidins,  but  it is only replacements of Oligomeric Proanthocya- nidins.  The composition and effects of these re- placements are quite different from Oligomeric Proanthocyanidins.

 

Oligomeric Proanthocyanidins is said to be a se- cret weapon among the pilots!  The topic “Oligo- meric Proanthocyanidins improves sight” caught the attention of the scientists was because during the WWII, before the pilots from the Royal British Airforce executed bombing tasks during nights, they would be given drinks containing Oligomeric Proanthocyanidins jam. Research showed that Oligomeric Proanthocyanidins accelerate the re- generation ability of rhodopsin, thus improving the sharpness of sight.  This helped the pilots much, who are expected to judge flying conditions with their eye and to have very good eye sight.

 

Research on Oligomeric Proanthocyanidins has expanded to the protection of blood vessels and

	 	other fields.  People now extensively use the an- thocyanin that is rich in the ripened fruits of Oli- gomeric Proanthocyanidins to treat many condi- tions, including bloodpoisoning, urinary system infections, kidney stone, arteriosclerosis, cataract, macular degeneration, nyctalopia, pathological change in the retina, varicosity, and blood vessel conditions in chronic diabetes patients. 

 

Oligomeric Proanthocyanidins and healthy eyes: First, scientists noticed that most of the eye-related problems are caused by conditions in the retina, bone glue or intraocular pressure, all of which can be traced to the blood circulation within the eye. With the increase in age, the metabolism process gets down, and the overuse of the eye causes free radical damages, poor blood circulation and ab- normalities in the smoothness of capillary circula- tion.  Therefore, when the eyeball, being one of the nerve ends, does not receive enough nutrition, the bone glue substances within the eyeball will drop, which affects the elasticity of the eye ball so that it is prone to be distorted or become inelas- tic.  Because of the poor blood circulation, some fluid tends to gather in the eye and causes abnor- mal pressure so that the eye pressure increases, and causes irritation, soreness, or even damages in the eye tissue and the occurrence of glaucoma and cataract.  Therefore, the anthocyanin content in Oligomeric Proanthocyanidins is widely used to maintain the intactness of blood vessels, the elas- ticity in capillaries, as well as normal blood circula- tion and normal eye pressure.  The extract of Oli- gomeric Proanthocyanidins does not produce any side effect, and will not interfere with the general drugs. No side effect is found in pregnant patients or patients in lactation.

B. Effects of Lycopene :

 

Lycopene fights oxidation and cell tumorigenesis. In March, 1997, during an international academic forum held by American Health Fund in New York, the effects of Lycopene and tomato products in fighting cancer were extensively discussed.  Ex- perts and scholars from all over the world dis- cussed intensively the of tomato and carotenoid, which is also called Lycopene, to the health of the human body. The research teams led by many ex- perts and scholars have proven out of epidemio- logicstudies and experiments that Lycopene helps

	 	 	 

 

  

2

  

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

	the human body fight many cancers, including prostate cancer, breast cancer and cancer in the alimentary canal (such as large intestine cancer, rectum cancer and stomach cancer), as well as reduces the risk of cardio blood vessel conditions. 

 

Lycopene is one of the more than six hundred types of carotene in nature.  It is not in a loop structure, but its ability to remove the singlet oxy- gen free radicals is two times stronger than theβ- carotene, and 100 times stronger than Vitamin E.   Since Lycopene cannot be produced within the human body, we can only get it from our diet. Many fruits contain Lycopene, especially red- colored fruits, such as the pin grapefruit, almond, guava, papaya, and water melon.  However, to- mato remains the best source. Studies show that a hundred kilograms of fresh tomatoes contains about 0.88-4.2mg Lycopene.  The more ripened and red a tomato is, the more Lycopene it con- tains. This figure for pink grapefruit is 3.36mg, for guava 5.4mg, and water melon 4.9mg.

 

The content of Lycopene depends on the type, growth method, harvesting ripeness and storage conditions of tomatoes. Overseas studies show that the content of Lycopene in the type called Flavourtop is about 4950ug /100g, and in Gold Sunrise only about 21ug /100g.  Tomatoes grown on soils treated with 300kg ammonium nitrate per hectare contain more Lycopene than those grown on soils treated with 100kg ammonium nitrate per hectare.  Red and ripened tomatoes contain 2.5 times more Lycopene than pinkish tomatoes. If stored under 18oC, the pinkish Sunny type toma- toes contain more Lycopene than those stored under 0oC.  Therefore, farmers could choose the right type and fertilization method to increase the content of Lycopene in tomatoes.  As a general customer, you may choose red and ripened toma- toes stored under a temperature of above 0oC.

 

The research team led by Dr. Giovanucci from Harvard Medical School found that a diet rich of tomato  products  contains  powerful  antioxidant and can thus remove redundant free radicals with- in the body and reduce the risk of prostate cancer. During the six years between 1986 and 1992, re- searchers studied on more than 47 thousand men between the age of 40 and 75, observing their health conditions and dietary habits.  They found

	 	that the risk to get prostate cancer for those who took tomato-related products every week was 21% to 34% less than the rest. 

 

Other studies show that the anticancer ability of Lycopene goes beyond the prostate cancer.  Vitro experiments carried out by the Israeli BenGurion University  and  Seroka  Medical  Center  showed that Lycopene also prevents the growth of breast cancer, lung cancer and endothelial cancer cells. Many medical studies from overseas countries also report that Lycopene not only removes free radicals, but reduces the risk of cancer, protects low-concentration lipoproteins from free radicals, lowers the concentration of cholesterol in blood, thus preventing cardio blood vessel conditions.

 

Researchers from India show that Lycopene helps in improving the sterility in males.  The Lycopene in water melon, grapefruit, tomato and other fruits and some of the shellfishes can increase the quantity of sperms.  The National Medical Asso- ciation of India made a study on 30 sterile men aged between 23 and 45. Researchers found that the content of Lycopene in these men were low, so that they were administered 2mg Lycopene twice daily for three months. After three months, the quantity and activity of sperms produced by them increased evidently.  There was also a case that six sterile men successfully impregnated their spouses after treatment, which proved the direc- tion effect Lycopene has on sterility.   Research- ers report that the oral administration of Lycopene indeed helps to treat sterility caused by uncertain reasons.

 

C. Effects of Green Tea Polyphenols (GTP) : 

 

Green Tea Polyphenols (GTP) is a general name for Catechins, flavonoids, phenolic acids, Anthocyan and other chemical compounds.  It accounts for 15% to 25% of the total dry weight of tea. The most important content in GTP is catechins. The multiple active –OH base in the molecules of GTP can stop the chain reaction of free radicals within the human body, thus removing the O2-.  It has similar effects of SOD. GTP can remove as much as more than 98% OH- and over-oxidized free radicals, which is more effective than Vitamin E and Vitamin C. GTP protects cell membranes and cell walls, and removes very effectively the over-

	 	 	 

 

  

3

  

 

Bio-tech Micro Molecules Nutrition Supplement  生物高科技-細胞小分子營養食品

 

	oxidized free radicals in lipids.  GTP restrains and kills bacteria. It can effectively lower the absorp- tion of cholesterol by the large intestine, and pre- vent arteriosclerosis. It is a powerful restraint for HIV reversion enzyme. It improves the immunity, prevents tumor, fights radiation, and slows down the aging process. Toxicological studies show that GTP is safe and toxic-free. Below are some of the ways GTP (primarily catechins) can be used: 

 

1) Anti-oxidation for lipid :

GTP is a natural anti-oxidant for lipid. Its anti- oxidation activeness is better than the artificially synthesized BHA and BHT as well as Vitamin E. It is widely used in the food industry to prevent and delay the oxidation and decay of lipids.

 

2) Pigment protection :

GTP prevents the degeneration and bleaching of natural pigments and β- carotene. It is said that its effect is 20 times higher than Vitamin C.

 

3) Deodorant :

As GTP is very effective in removing the odor of methyl mercaptan, it is used in Japan in the mak- ing of deodorant gums and cigarette filters to pre- vent the bad breath of smokers. Researchers have done tests on the excrements of hogs, chicken and human. After two-weeks dietary intake of GTP, the odor of the excrements moderates, because GTP can kill and restrain many stinky bacteria within the intestine.

 

4) Prevents oxidation and delays aging :

GTP can remove the redundant free radicals with the body, protect the structure of cell membranes, and delay the aging process. A number of experi- ments show that GTP has stronger anti-oxidation activeness than Vitamin E. This effect becomes even more stronger when administered together with Vitamin C and Vitamin E.

 

5) Anti-cavity :

The anti-cavity effect of tea used to be considered the effect of fluorine in the tea water. Fluorine can replace the hydroxyl in the hydroxylapatite of teeth and become fluorapatite, to give protection to the teeth enamel against the corrosion of acid substances. It is clinically proven that GTP is pow- erful in restraining bacteria that cause cavity, and in reducing tooth plaque and pericoronitis risks,

	 	while producing no adverse effects on beneficial microbes in the oral cavity. 

 

6) Antiseptic and anti-virus :

Green tea and scented tea are more antiseptic than red tea.  This has something to do with the amount of GTP in them. Some people believe that the antiseptic effect of GTP comes from the ability of polyphenols to deposit bacterial proteins, which will be denaturalized and deactivated. Modern sci- ence believes that the effect of tea primarily comes from catechin.  Catechin restrains many microbes that are detrimental to human health, such as bot- ulinum toxin, while having no bad effects on the reproduction of microbes that are beneficial to the intestines, such as lactobacillus.  There are clini- cal reports of cases in which tea water is used to treat Shigellosis and to restrain the reproduction of pathogenic bacteria.

 

7) Lowers blood fat and relieves arteriosclerosis : 

GTP plays an important role in fat metabolism of an organism. It effectively restrains the increase of cholesterol content in blood plasma and liver, and helps discharge lipid compounds in excrements. Therefore, it not only prevents arteriosclerosis, but reduces weight and fat. A study team from a medi- cal university gave away GTP medicines to 200 people in 4 groups. After a ten-month administra- tion, the team conducted a double blind control ex- periment, and found that GTP lowered the content of cholesterol and triglyceride in blood serum by about 19%. They also noticed that the difference of ratios between high-concentration lipid protein and low-concentration lipid protein before and af- ter the experiment was 36.1%, which indicated that GTP has a potential effect to prevent high blood fat, coronary heart disease and arteriosclerosis.

 

8) Multiple medicinal effects :

GTP, and especially its catechin derivatives re- strain tumor cells and mutation. Moreover, cate- chin derivatives can also alleviate the detriment of heavy metals to human health, and protect the hu- man body from radiation. A prestigious American company developed foundation liquids containing catechins, and indicates in the description of the cosmetic that it can prevent skin cancer caused by ultraviolet radiation and the pre-aging of the skin.

	 	 	 

 

  

4

  

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

	D. Health protection effects of grape seed extract: 

  

Grape Seed Extract Proanthocyanidin (GSPE) is the most popular antioxidant on the market to remove free radicals. The absorption rate is over 95%. In Europe, grape seed is called the “cos- metic for the skin that is taken orally.” It is one of the most effective antioxidants that nature gives us. It does not only prevent the early wrinkling of the skin, but nurtures the skin and removes free radicals. 95% contents in clean and pollution-free grape seed extracts are a group of natural substances called Oligomeric Proanthocyanidins.

 

GSPE is also a natural polyphenol compound that is one of the flavone. [1~4]These compounds are the polymerization of flavanols of different num- bers, heated in acid solutions to produce leucoan- thocyanins or proanthocyanidin, which is also called pycnogenols. [5, 6]The most extensively studied are 5,7,3’,4’-tetrahydroxyflavan-3-o1 in grape seed, i.e. compounds that are polymeriza- tions of (+)-catechin and (-)-epicatechin, which is also called leucocyanidins or procyanidins. [7] is a powerful antioxidant and is usually found in fruit skin or plant stems. It primarily protects the contents in plants that are easily oxidized. As ear- ly as in 1950s, scientists in France were able to extract large amounts of proanthocyanidin from pine barks. As high as 85% of these extracts was proanthocyanidin. In 1970s, it was found that grape seed is a better resource for proanthocyani- din, in which the content of proanthocyanidin is as high as 95%. Studies in the latest decades found that proanthocyanidin is beneficial to the human body in many ways:

 

A) Prevents the early wrinkling of the skin :

 

In Europe and America, grape seed extract is con- sidered the “vitamin for skin” and the “cosmetic orally taken.” Skin is a connective tissue, the col- lagen and elastin in the skin play an important role to build its structure. The moderate crosslinking of collagen maintains the intactness of the skin. However, free radicals can cause collagens to over-crosslink, so that wrinkles and cysts appear on the skin. The grape seed extract can help col- lagens to crosslink moderately and remove free radicals, so as to keep the skin smooth and sup- ple. In addition, elastins can be degenerated by

	 	free radicals and elastasees, whereas grape seed extract can eliminate free radicals, stop the repro- duction of elastasees or reduce their activeness so as to improve the conditions of the skin. 

 

Researchers [2] have conducted epidemiologic re- sistant studies on grape seed extract, which indi- cated that the ratio of GSPE against IC50 (μmol/L) xanthine oxidase, elastasee, collagenase, hy- aluronidase, and β-Glycuronic acid sugar gluco- side enzyme are respectively 2.4, 4.24, 38, 80 and 1.1. GSPE is very effective in restraining the above-mentioned enzymes.

 

The grape seed contained in OPCSpa is a natu- ral sun block that protects the skin from ultraviolet harms. Dr. A. H. Arstilla from Finland found in his experiments that the sun can kill 50% human skin cells; but when protected by grape seed, 85% skin cells will survive. Free radical is one of the most important causes for the aging process and many other conditions. It is estimated that 80% to 90% age-related conditions have something to do with free radicals, including cancer, senile dementia, Parkinson’s Disease, skin pigment, cataract and heart diseases. The proanthocyanidin in grape seed repairs the damaged collagen and elastin fibers. Therefore, grape seed protects both from within and from without: preventing the early ap- pearance of wrinkles, and keeping the skin smooth and elastic forever.

 

B) Removes detrimental free radicals in the body : 

 

In 1980s the effects of free radicals on human health was gradually learned.According to modern medicine and nutriology, free radicals cause many diseases directly or indirectly. The Gradu- ate Student College of France Science Academy conducted an experiment on the effect of GSPE in removing free radicals, and found that GSPE is one of the most effective remover of free radi- cals found by far. Its activeness within the body is incomparable by other antioxidants. Bagchi.D[3] conducted an experiment on mice, comparing the effect of GSPE of protecting TPA-induced liver and brain tissues from the over-oxidation with that of VC, VE and β- carotene. It was found that at a dosage of 100mg/kg BW, GSPE, VC, VE and β- carotene all reduced the amount of reactive oxy- gen produced out of TPA induction, the ratio being

	 	 	 

 

  

5

  

 

Bio-tech Micro Molecules Nutrition Supplement  生物高科技-細胞小分子營養食品

 

	
respectively 70%, 18%, 47% and 16% with the peritoneal macrophage luminescent method, and 65%, 15%, 37% and 19% respectively with the cytochrome restoration method.  Also found was a dosage reaction relationship between GEPS and the production of reactive oxygen in perito- neal macrophage.  The result of the experiment showed that GSPE gives a better protection than other antioxidants against damages caused by oxidization. The epidemiologic studies conducted by Bagchi.D[10] also found similar results.

Free radical is one of the most important causes for aging and many other related diseases. It is estimated that around 80% to 90% age-related conditions have something to do with free radi- cals, including including cancer, senile dementia, Parkinson’s Disease, skin pigment, cataract and heart diseases. Therefore, removing free radi- cals helps much with a healthy body and youthful- ness. Proanthocyanidin in OPCSpa is more than 50 times stronger than Vitamin E and more than 20 times stronger than Vitamin C in fighting free radicals.

 

Control experiment examining the anti-oxida- tion abilities: Researchers examined the abil- ity of GSPE, VC, VE, β - carotene, superoxide dismutase, catalase and mannitol in removing OH- free radicals and –OH free radicals with the chemical luminescent method and cytochrome C restoration method. The results showed a con- centration reaction relationship between GSPE and its restriction on free radicals. With a concen- tration of 10mg/L, the restriction ability of GSPE over OH- free radicals and –OH free radicals were 78% and 81% respectively. Under the same conditions, these figures for Vc were 12% and 19% respectively, for Ve 50% and 75%, and for superoxide dismutase and catalase when acted jointly about 83% against OH- free radicals, and for mannitol 87% for –OH free radicals. In conclu- sion, GSPE is a much more powerful free radical eliminator than Vc and Ve.

C) Reduces the risk of inflammations in tissues:

Proanthocyanidin in OPCSpa is more than 50 times stronger than Vitamin E and more than 20 times stronger than Vitamin C in fighting free radi- cals.  Proanthocyanidin in OPCSpa reduces the

	 	
risk of inflammations in tissues by restraining pros- tate gland, cytokinin, histamine, lipoxygenase and cyclooxygenase.

 

This effect of Proanthocyanidin in GSPE caught the attention of scientists as early as in 1950s. its anti-oxidation ability restrains the synthesis and release of inflammation genes such as histamine, -hydroxytrypamine, prostaglandin, and leukot- riene, and restrains basophilic cell and mast cells in releasing allergic particles, thus improving skin allergy and allergic asthma symptoms effectively. In addition, it can also restrain the activity of HDC, and restrain the effects of hyaluronidase, [21] thus helping with the treatment of arthritis, gastric ulcer and duodenum ulcer.

 

D) Relieves allergy and allergic reactions : 

 

Proanthocyanidin in GSPE can reduce the release of histamine, and help the redundant histamine within the body to reenter cells. It can also re- strain the degranulation of mast cells, thus allevi- ating conditions such as allergy, asthma and hay fever. OPCSpa is the ideal nutrition supplement recommended by clinicians.

 

E) Strengthens blood vessels and improves circu- lation :

Proanthocyanidin in GSPE is used to improve the immunity of blood vessels and reduce the perme- ability of capillaries.  Several experiments on cap- illary permeability have proved its anti-oxidation effect and anti-enzyme effect.  [11, 12] With the increase in age, elastin fibers in arteries become hardened because of oxidization, and arterioscle- rosis is a key cause for cerebral and cardio blood vessel diseases among the elderly.  Another key cause for arteriosclerosis and heart diseases is the increase of low-concentration lipid proteins and cholesterol within the body.

 

Animal tests and clinical tests showed that the proanthocyanidin in GSPE can effectively lower the level of cholesterol and low-concentration lipid protein, prevents the formation of thrombus, and prevents the occurrence of cerebral and cardio blood vessel diseases.  [13]Preuss HG[14] stud- ies also indicated that proanthocyanidin in GSPE, when acting together with cadmium and zinc, can

	 	 	 

  

  

6

  

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

 

 

 

	

lower the increase of systolic pressure caused by increase of age among normal rats. In the tests, rats in the control group were given basic feed- stuff, while 5 mg/kg Gr, 18 mg/kg Zn, 260 mg/ kg proanthocyanidin were given into the feed- stuff for rats in the test group. The initial blood pressure of the two groups was both 122mmHg. Seven months later, the ystolic pressure of rats in the control group raised to 140mmHg, whereas in contrast that of the rats in the test group lowered to between 110~114 mmHg during the first few months, and then raised to 120mmHg, which was much lower than in the control group.

 

Researchers believe that aging and age-related chronic disease have something to do with the glycation of protein/nucleic acid and tissue trau- mas caused by the increase of free radicals.  The resistance of insulin that appears with the increase in age might be the foundation for glycation and the formation of free radicals.  In researches re- garding the effect of GSPE and cadmium and zinc on insulin sensitivity, it is noticed that the effect comes into play be reducing the formation of free radicals.  In addition, with the increase in age, the elastin fibers harden from the oxidization process, which is a main cause of hypertension among the elderly.  Proanthocyanidin in GSPE can lower the blood pressure by improving the elasticity of blood vessels.  Animal tests and clinical studies show that it lowers the blood pressure by lowering the level of cholesterol, reducing the cholesterol sedi- ment on vessel walls and restraining the activity of vessel tension enzymes.

 

The Proanthocyanidin in OPCSpa can improve blood circulation, restore the capillary functions lost, and strengthen up fragile blood vessels, mak- ing them more elastic. Proanthocyanidin is called the Atherosclerosis Antidote. For those suffering from insufficient artery and vein functions, Proan- thocyanidin could help to ease pain, edema and nocturnal spasm, so that many clinicians recom- mend OPCSpa to their varicosity patients.

 

F) Improves eyesight :

 

Researchers conducted experiments on men to examine the effect of Proanthocyanidin on eye fatigue, [22] administering GSPE Proanthocya- nidin 300mg daily to 75 cases those who work

	 	

permanently before a computer screen. After two months, the relative sensitivity and subjec- tive symptoms evidently improved. In clinical ex- periments on short-sighted cases, 150mg GSPE Proanthocyanidin is administered to 200 cases who suffer from non-inflammation retina changes. After two months, it is reported that the sight of these cases improve greatly [23, 24].

 

Now, GSPE Proanthocyanidin is used extensively. Its health protection function comes from its abil- ity to remove free radicals.  Besides, it also has great biological potentials.  When combined with collagens, it can stabilize the activity of cell mem- branes and resistant enzymes, which will make it a popular health supplement.

 

Proanthocyanidin in OPCSpa improves the sight. A clinical research conducted in Europe on 100 cases with no eye conditions discovered that Proanthocyanidin can improve sight under dim light, which means it will be helpful for night driv- ers and computer workers. Doctors in Europe and America also recommend it to their patients who suffer from retina conditions caused by diabetes.

 

G) Fights cancer :

 

The cancer-fighting ability of Proanthocyanidin in GSPE has been extensively covered.  The epi- demiologic study by S. S Joshi et al [15] noticed the cytotoxicity of proanthocyanidin on some tu- mor cells.  Used in the study were MCF-7 human breast cancer cells, A-427 human lung cancer cells, CRL1739 human stomach cancer cells and K562 chronic leukemia cells, and the concentra- tion of proanthocyanidin used was 25, 50 mg/L. The observation time point was 0 – 72 h.  When compared with the normal stomach mucous mem- brane and the normal J774A1 urethra epithelium cells, it was found that 25mg/L proanthocyanidin has cytotoxicity against MCF-7 human breast cancer cells, A-427 human lung cancer cells, and CRL1739 human stomach cancer cells. Its restric- tion of cancer cell growth at 24, 48 and 72 h was respectively 7%, 30%, and 43%; at 50mg/L and some time points its restriction against MCF-7 hu- man breast cancer cells was 1%, 30% and 47% respectively; similar effects on A-427 human lung cancer cells and CRL1739 human stomach can- cer cells were observed, but not on K562 chronic

	 	 	 

 

  

7

  

 

Bio-tech Micro Molecules Nutrition Supplement  生物高科技-細胞小分子營養食品

 

 

	leukemia cells.  In addition, Proanthocyanidin in GSPE facilitates the growth and survival of normal human stomach mucous membrane and the nor- mal J774A1 urethra epithelium cells. 

 

In studies about the relationship between tobacco and cancer, M.Bagchi et al [16] also explored the protective effect proanthocyanidin has on oxidiza- tion restriction and cell apoptosis of keratinocytes of the human oral cavity induced by smokable to- bacco extracts (STE).  Statistics show that in the US 1/3 of all tumors are tobacco related, oral cav- ity cancer accounting for 3% of all tumors.  In their experiment, they studied the effect of STE on lipid peroxidation (LP), cytochromes restoration (CCR), DNA fraction and cell apoptosis, and evaluated the protective effect of various antioxidants. [Separate and culture cells from the human oral cavity tissue, treat them with STE (0~300 μg/mL) for 24 hours, examine the generation of superoxide anions with CCR, examine tissue oxidization and trauma with LP and DF, and examine the programmed cell ap- optosis with Flow Cytometer.]

 

The protective effect of 75 μmol/L VC, 75 μmol/L VE, VC+VE and 100 μmol/L GSPE proanthocya- nidin on the above-mentioned traumas were then compared.  After the cells are treated with 300 μg/mL STE, it was observed that LP and DF in- creased by 3.5 to 6 times. When treated with anti- oxidants, the protection was between 34% to 69%. After treated with 100,200, and 300 μg/mL STE, the programmed cell apoptosis increased respec- tively by 9%, 29% and 35%.  After the treatment with antioxidants, the protection increased by 40% to 72%.  Similar results were noticed in LP, CCR and DF experiments.  Results showed that GSPE proanthocyanidin is the most effective antioxidants among all.

 

H) Prevents radiation :

 

The free radical theory is a basis for trauma caused by radiation. After radiated, an organism produces from within, which causes lipid peroxidation and other damages.  GSPE proanthocyanidin is ef- fective in eliminating free radicals and restraining damages resulted from oxidization.

 

According to a test report, [17] mice loaded S180sarcoma were given 60 Co γ local radiation, oral

	 	

intake of GSPE proanthocyanidin, and local radiation plus oral intake of GSPE proanthocyanidin. 12 days after the loading of tumor cells, the tumor weight, white blood cell amount, spleen lymphocyte conversion and other indices were examined. The result showed that the average tumor weight of the control group was the high- est; the restriction on tumor in the group treated with radiation plus high-dosage proanthocyanidin administration was found higher than the other two groups; the amount of white blood cells in the group singularly treated with radiation was lower than the other two groups. The statistical t and χ2 examinations found great disparity (P<0.05). 

 

The result also showed that compared with the group that did not receive radiation, the MDA lev- els of the other two groups were higher, which ap- parently had something to do with the intensified reaction of lipid peroxidization and the accumula- tion of oxidization products within the body.  The administration of GSPE proanthocyanidin lowered the MDA level, the bigger the dosage, the greater the decrease, which indicated that proanthocya- nidin  restricted  the  lipid  peroxidization  caused by radiation.  This might be the main reason that proanthocyanidin prevents damages caused by radiation.

 

Russians have long realized the protection proan- thocyanidin has over damages caused by radia- tion.  Russian astronauts have been given a veg- etarian drink rich in proanthocyanidin, which helps them avoid damages from radiation when flying in a spaceship. The explosion of Chernobyl Nuclear Power Station in the Soviet Union resulted in se- rious nuclear pollutions, and many people living nearby were traumatized.  Then a red wine called Crimean was suggested to them – one that rich in proanthocyanidin to alleviate the adverse effects nuclear leakage caused to the human body.

 

All in all, the protection of proanthocyanidin on ra- diation is drawing more attention.  While bringing people great benefit in their lives and work, such as TV, computer, microwave oven and mobile phone, the development of modern technology is also jeopardizing human health with a bigger exposure to electromagnetic radiation.  Health supplements containing proanthocyanidin to fight against radia- tion damages will have a great future.

	 	 	 

 

  

8

  

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

	I) Prevents mutation : 

 

1) Test on mitochondrion mutation :

Used Saccharomyces cerevisiae S228C(α- prototroph)cells, and regarded the mutant   of Respiratory Deficient as the manifestation of mi- tochondrion mutation. The occurrence of mutants was recorded. The result shoed that at 0, 0.25 and 0.5mg/L GSPE proanthocyanidin, the occurrence of mutation was respectively 1.7×10-2, 0.9×10-2, and 0.6×10-2, with the ratio between the control group and the test group being respectively 1, 0.5 and 0.35.  It is obvious that GSPE proanthocyani- din can effectively lower the occurrence of mito- chondrion mutation [18].

 

2) Test on nucleus mutation:

Used Saccharomyces cerevisiae S228C(α - pro- totroph )cells. The number of L - canvanine sen- sitive mutated as L-canvanine tolerant was re- corded. The result showed that at 0, 0.25 and 0.5mg / L GSPE proanthocyanidin, the occurrence of nucleus mutation was respectively 1.95×10-8, 0.25×10-8, and0.15×10-8, with the ratio between the control group and the test group being respec- tively 1, 0.12 and 0.08. The occurrence of nucleus mutation in the test group reduced by 88% to 92% [19, 20].

 

E. Health effect of pine bark (Pycnogenol) : 

 

Pycogenol is an antioxidant extracted from the bark of the rare Conifer Pinus Pinaster growing along the south coast of France.  Pycogenol is a water - solvent biological flavone extract contain- ing many organic acides, including catechins, pro- cyanidis, taxifolins and phenolic acids. It’s a pow- erful antioxidant that fights against free radicals that damage cells.

 

Pycogenol strengthens blood vessels, facilitates blood circulation, restrains inflammation, helps bruises to heal, and prevents cells from mutation. It also has the following effects:

1) Makes the skin healthier :

Pycogenol protects the collagen of the skin, keep- ing it elastic and supple. It prevents the early signs of wrinkles, protects the skin against suntan, and prevents acnes and eczema.

	 	
2) Mollifies chronic fatigue syndrome :

Pycogenol improves blood circulation within the brain, preventing headache, irritation, difficulty in concentration, insomnia and other chronic fatigue symptoms.

3) Eases premenstrual syndrome :

Pycogenol regulates hormone secretion, balanc- ing the level of free radicals within the body and al- leviating premenstrual conditions, such as anxiety, depression, ache, fatigue and insomnia.

 

Pycogenol also relieves pains in arthroses.  It re- stores the collagen in the damaged connective tis- sues, improves the activity of the joints, thus eas- ing pains in the arthroses, neck and back.

 

4) Prevents senile dementia :

After death, cerebral nerve cells will not revive, and free radical is the cause for cerebral cell death. Pycogenol can fight against damages caused by free radicals and delay the aging process.

It is recorded that pine bark was used medically as early as in the thirteenth century.  In the winter of 1534, the French adventurer Jacques Cartier ex- plored Canada in a boat.  On his way, most of his crew died from blood poisoning, and it was lucky for him to meet an Indian who taught them pre- paring tea with pine bark.  This saved many lives. Four hundred years later, pine bark was studied in colleges and was found rich in biological flavo- noids.

 

F. Heath effects of red wine extract :

 

Past studies indicated that red wine prevented the attack of heart diseases.  Recently, a research re- sulted published by an American scientist proved that grape skin and grape seed contain a natural chemical substance that prevents cancer.

 

Scientists extracted a dimmer called β -prccycli- dine from grape skin and seed, and applied it on mice loaded breast cancer.   The result showed that the chemical caused the tumor to shrink.

 

According to the researchers, presently there are some medicines on the market that can control the development of conditions in estrogen-reliant

	 	 	 

 

  

9

  

 

Bio-tech Micro Molecules Nutrition Supplement  生物高科技-細胞小分子營養食品

 

	
breast cancer cases.  The natural chemical they refined has the same function on restraining the development of breast cancer.  Researchers also indicated that they were quite astounded that they could extract this chemical from natural resources. In addition, the test proved that the extract greatly reduced the size of the breast cancer within the body of all mice tested.  It is even more astonish- ing to know that the tumors in some mice totally disappeared.

 

Researchers believe that this natural extract is more effective when used for prevention than for treatment, because the cancer-fighting medicines currently existing are quite effective. Therefore, it is suggested that mature females take in this natural compound in their diet, such as red wine [containing 25% to 45% red wine extract], so as to prevent breast cancer when in the future their estrogen level drops.

 

According to the researchers, amongst females in menopause who suffer breast cancer, 70% cases are caused by a high level of estrogen. There is a treatment to reduce the generation of estrogen by reducing the activity of aromatase, so that breast cancer is forced to stop growing because of the lack of continued supply of estrogen.  The natural substance they extracted from grape functions in much the same way.

 

Researchers clarified that they recommend red wine to females for the prevention of breast cancer. This does not mean that females are encouraged to drink excessively.  The dosage on mice is half a bottle wine daily.  For healthy females, a glass of wine or some grapes (with the skin and seeds) a day is enough to lower the amount of estrogen in circulation.  When asked why white wine does not have the same effect, researchers said that the materials used in red wine making are intact grapes, i.e. grapes with the skin and seeds, and after the fermenting process the liquid is no longer simply grape juice. In contrast, white wine is often made from grape juice, and without the skin and seeds it does not have the cancer-fighting effect.

 

G.  How to take OPCSpa :

 

Take one pill morning and evening. It produces no side effects even after long-term use.

 

Take continuously ten days for healthy people, and 25 days for those that have any conditions for pronounced health-improving effect.

	 	
The dosage can be adjusted according to the physics and health conditions of different people. The dosage can be increased for those who have greater exposure to the sun.

 

It is normal if you experience headache.  Please be assured that there is no problem in continuing the administration.

 

H. OPCSpa FAQ

 

1) What is proanthocyanidin?

All vegetables in nature that have various colors contain proanthocyanidins, therefore it is benefi- cial to our skin and body to eat more fruits and vegetables. However, the proanthocyanidin we take daily is very limited. Scientists discovered that the content of proanthocyanidin in grape seed is as high as 95%. The natural OPCSpa benefits our health greatly.

 

2) What is free radical?

The free radical theory is an age theory commonly accepted in the science circle. The oxygen we take in has an oxidization effect which produces the detrimental free radicals. Environment pollution, ultraviolet radiation, smoking, pesticide, ozone, alcohol and many chemical drugs will also increase the amount of free radicals within our body, and aging and ailments are thus caused.

 

3) How does OPCSpa fight free radicals?

Free radical is one of the key causes for aging and many conditions.  It is estimated that around 80% to 90% age or degeneration related diseases have something to do with free radicals, including senile dementia, Parkinson’s Disease, skin spot, cataract, heart disease, and cancer. Therefore, to remove free radicals is key to maintain a healthy and young body.

 

4) How does OPCSpa protects the skin?

The  proanthocyanidin  in  OPCSpa  restores  the damaged collagens and elastin fibers, and the damage of these two substances is a key factor that causes wrinkles and slackened muscles on the face. Many high-end cosmetics on the market, such as eye creams and sun blocks contain proan- thocyanidin in order to protect the skin against ul- traviolet radiation and the formation of wrinkles.

 

5) Is it safe to take OPCSpa?

OPCSpa is a safe diet supplement for your health and is free from any toxic effect.  The Pasteur In-

	 	 	 

 

  

10

  

 

生物高科技-細胞小分子營養食品 Bio-tech Micro Molecules Nutrition Supplement

 

	stitute of France and the Cytotest Cell Research of Germany both conducted a thorough study on proanthocyanidin, and proved it is as safe as Vi- tamin C. 

 

6) Is it enough to eat grape seeds?

Grape seed is not tasty and is difficult for the digestion system. Most will be discharged from the body with the excrement, so experts suggest that the grape seeds be grounded, boiled with water for ten minutes and taken. But you will only see the effects after taking in large amounts of such grape seed water.

 

7) How long will the OPCSpa effects show up? 

Most customers see pronounced effects of OPC- Spa in preventing allergy and improving immunity. However, to improve your skin conditions, it re- quires a continued administration of three to six months to see a good result (the period may differ depending on different conditions of individuals).

 

8) What benefits can OPCSpa bring?

OPCSpa delays aging, improves sight, helps bruises to heal, prevents cancer, reduces the risk of phlebitis and arthritis, prevents prostate con- ditions, alleviates inflammations resulted from sports activities, improves the sexual functions, energizes, improves the functions of the circula- tion system, prevents the worsening of psycholog- ical conditions, reduces the risk of heart diseases, prevents strokes, improves the immunity system, improves allergic conditions, eases fatigue, and prevents cold and flu.  Use it before your aging process begins, so that it will help remove your wrinkles and keep your skin supple and smooth. In addition, OPCSpa is also effective in prevent- ing and improving conditions associated with hay fever.

 

Based on reports by Researcher Proto F,Carloni C.Meucci B,et al information from other research- ers.

 

[1] Haslam E.Plant polyphenols [J] .Cambridge University Press.1989,14~15

[2] Masquelier J,Michaud J,Laparra J,et al.Intrenat [J] .J Vit Nutr Res,1979,49:30

[3] D.Bagchi,et al.Protection effects of grape seed proan- thocyanidins and selected antioxidant against TPA-Induced

	 	hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice [J]. Gen. Phar- mac, 1998,30(5):771~776 

[4] Bombardelli E. [Z] GB-1,541,549

[5] Indena.S P A.Internal Report(Data on file) [Z]

[6] DA siva R J M,Rigaud J,Cheynier V,et al. [J]. Phytochem- istry,1991,30:1259

[7] Lawrence J P,Liana N.Hrstich and bock G [J].Chan Phyto- chemistry,1986,25:223

[8] D Bagchi,et al.Oxygen free radical scavenging abilities of Vitamins C and Vitamins E,and a grape seed proanthocyani- dins extract in vitro research [J].Communications in Molecular Pathology and Pharmacology, 1997, 95 ( 2 ):179~189

[9] Barbier A,Maffrand J P.Savi P. in: Endotelonet unite circulatoire [M].John Libbey (Ed.) Paris - London,1988,39~41

[10] Doutremepuich J D,Baibier A,Lacheretz F. [Z].Lymphol- ogy,1991,24:135

[11] Ross R. [J].Nature,1993,362:801

[12] Preuss HG,et al.Chromium,Zinc,and Grape seed extract(Flavonoids) can overcome age-related increases in SPB normotensive rats [J] .Journal of the American College of Nutrition,1997,16(5):43

[13] S S Joshi,et al.Cytotoxicity of a novel grape seed proan- thocyanidins extract against elected human cancer cells [R]. Second International conference on Natural Antioxidant and Disease June 24~27,1998,Helsinki, Finland

[14] M Bagchi,et al.Comparative protective abilities of Vitamins C and E and a grape seed proanthocyanidins extract(GSPE) on smokeless tobacco-induced oxidative stress and apop- topic cell death in Human Oral keratinocytes [J] .Toxicological Sciences, 1998,922:187

[15] Marmiroli A,Restivo F M,Donnini C,et al. [Z] Molec.Gen. Genet.177,581,1980

[16] Magni G E,von Borstel R C. [Z] . Genetics. 47,1097,1962 [17] Puglisi P P. [Z] Molec. Gen. Genet. 103,248,1968

[18] Godeau R G,Gavignet-jeannin G,Groult N,et al. [J] . Path. Biol,38,608,1990

[19]  Fusi  L,Czimeg  F,Pesce  F,et  al.  [Z]  .Ann  Ott  Clin Ocul.114,575,1998

[20]   Moriconi   S,Bellezza   P   G.   [Z]   .Ann   Ott   Clin Ocul.114,585,1998

[21]  Proto  F,Carloni  C.Meucci  B,et  al.  [Z]  Ann  Ott  Clin Ocul.114,85,1998

 

【Manufacturer】Made in U.S.A

【Specification】60 capsules/bottle, 500mg/capsule

【Shelf life】2 years

【Caution】 This product cannot replace medication

 

*These statements have not been evaluated by the Food and Drug Administration. This product is not in- tended to diagnose, treat, cure or prevent any disease.

 

		This product shall be stored at a room temperature (below 26°C or 80°F). The shelf life for this product is two years. 

Other matters requiring attention:

 ̇ Not to expose to high temperature.  ̇Not to be placed under the sun or in the overheated trunk.  ̇Not to store it in the refrigerator.  ̇To tighten the lid after opening, and to finish using the bottle within 45 days.  ̇Please check the product before purchasing.

 

 

11eworld_ex1012.htm

EXHIBIT 10.12

 

SmartWage/RedWage Payroll Card Services Agreement

This Agreement is made and entered into by and between RedWage, LLC (“RedWage”) and the business entity listed in the Customer Application (“Customer”) and sets forth the terms and conditions pursuant to which RedWage will provide the SmartWage Payroll Card service to Customer as provided for herein.

 

	
1.

	
Introduction.

 

	 	
1.1

	
Review. Customer promises to read this Agreement carefully, and to understand the terms and conditions of this Agreement prior to submitting it to RedWage. In addition, Customer acknowledges and agrees to review the RedWage Privacy Policy and the RedWage Site Terms of Use(collectively referred to as the “Website Terms of Use”) the current versions of which are posted on the RedWage website, prior to entering into this Agreement. By submitting and entering into this Agreement, the Customer acknowledges that it has reviewed and agrees with the terms of this Agreement and that the terms and conditions of this Agreement and the Website Terms of Use will govern all aspects of the relationship between RedWage, the Customer and the Cardholder in connection with the provision of the RedWage Payroll Card Solution services. If Customer has any questions about any of the provisions in this Agreement, an authorized representative of the Customer with the legal power and authority to bind Customer (an “Authorized Representative”) must contact RedWage via telephone or email prior to submitting this Agreement and accepting such terms. Customer agrees to refer frequently to the RedWage website for regular updated information about the Payroll Card Solution services, the associated fees, charges, features and benefits of such service, and the Website Terms of Use. If Customer determines that it is unwilling to be bound by the terms and conditions of this Agreement, Customer agrees that it will not submit and enter into this Agreement. RedWage reserves the right to accept or decline the Agreement, in RedWage’s sole discretion.

	 	
1.2

	
Revisions by RedWage. CUSTOMER ACKNOWLEDGES AND AGREES THAT CLICKING “I AGREE” IS THE LEGAL EQUIVALENT OF THE AUTHORIZED REPRESENTATIVE OF THE CUSTOMER MANUALLY SIGNING AND SUBMITTING THIS AGREEMENT, AND CUSTOMER ACKNOWLEDGES AND AGREES THAT, SUBJECT TO THE ACCEPTANCE OF THIS AGREEMENT BY REDWAGE, UPON CUSTOMER’S CLICKING ACCEPT, CUSTOMER WILL BE LEGALLY BOUND BY THE TERMS AND CONDITIONS OF THIS AGREEMENT. CUSTOMER UNDERSTANDS THAT THIS AGREEMENT AND THE WEBSITE TERMS OF USE MAY BE AMENDED FROM TIME TO TIME, AND AT ANY TIME, BY REDWAGE, WITH REVISED TERMS POSTED ON THE REDWAGE CUSTOMER PORTAL AND PUBLIC WEBSITE. REDWAGE WILL NOTIFY CUSTOMER OF CHANGES TO THIS AGREEMENT OR THE WEBSITE TERMS OF USE AT LEAST THIRTY (30) DAYS PRIOR TO SUCH CHANGES BECOMING EFFECTIVE, WHICH MAY BE VIA EMAIL, A NOTICE ON THE CUSTOMER PORTAL, OR OTHER COMMERCIALLY REASONABLE METHODS. CUSTOMER UNDERSTANDS THAT BY CONTINUING TO MAINTAIN A REDWAGE ACCOUNT AFTER ANY APPLICABLE CHANGE(S) WITHOUT PROMPTLY OBJECTING TO SUCH REVISED TERMS OF THIS AGREEMENT OR WEBSITE TERMS OF USE I N WRITING, CUSTOMER IS ACCEPTING THE TERMS OF THE REVISED AGREEMENT AND/OR WEBSITE TERMS OF USE AND CUSTOMER WILL BE LEGALLY BOUND BY THE TERMS AND CONDITIONS AS SO REVISED.

	
2.

	
Scope of Agreement.

	 	
2.1.

	
SmartWage Payroll Card Solution. The SmartWage Payroll Card Solution service (“Service”) is a funds distribution service whereby RedWage enables its Customers to distribute wages, salaries, expense reimbursements, prepaid travel funds and other funds to such Customer’s employees. Funds are distributed by Customer by means of RedWage cards (the “Card(s)”), which access certain card networks (“Networks”). The Cards are issued by The Bancorp Bank, or applicable future subsequent bank (the “Issuing Bank”), and the Issuing Bank is a member of the Networks. RedWage provides the Service in accordance with the Issuing Bank and Networks’ rules, and Customer’s use of the Service is subject to approval for conformance with such rules. As such, the Service may be modified from time to time as necessary to remain in compliance with the Issuing Bank and Networks’ rules, as well as applicable laws. Subject to the terms and conditions hereof, Customer hereby subscribes to the Service, and RedWage shall make the Service available to Customer. During the term of this Agreement, Customer agrees that RedWage shall be the exclusive provider to Customer of services that are the same as or similar to the Service provided under this Agreement.

 

  

1

  

	 	
2.2.

	
Customer Application. RedWage is required under Issuing Bank rules, Networks’ rules and federal law to obtain, verify and record information that identifies each business that opens an account and the personal information of its owners and/or representatives. The information regarding Customer that is required by RedWage includes, but is not limited to: company name, physical address, federal tax ID, bank account, business owner’s social security number, date of birth, driver’s license, and/or other identifying information. Such information will be treated as confidential information of the Customer. RedWage reserves the right to decline to open an account for Customer, for any reason in its sole discretion.

	 	
2.3.

	
Employee Enrollment. RedWage is also required under Issuing Bank rules, Networks’ rules and federal law to obtain, verify and record the personal information of each Cardholder (as defined in Section 2.4 below). The information regarding Cardholders that is required by RedWage includes, but is not limited to: such Cardholder’s name, physical address, date of birth, and social security number or other acceptable government-issued ID. Where the information provided cannot be verified, RedWage will contact Customer and Employee directly to obtain additional information. All such personal information will be treated as confidential information of the Employee. RedWage reserves the right to decline any Employee enrollment, for any reason, in each case in its sole discretion.

 

	 	
2.4.

	
Employee Enrollment. RedWage is also required under Issuing Bank rules, Networks’ rules and federal law to obtain, verify and record the personal information of each Cardholder (as defined in Section 2.4 below). The information regarding Cardholders that is required by RedWage includes, but is not limited to: such Cardholder’s name, physical address, date of birth, and social security number or other acceptable government-issued ID. Where the information provided cannot be verified, RedWage will contact Customer and Employee directly to obtain additional information. All such personal information will be treated as confidential information of the Employee. RedWage reserves the right to decline any Employee enrollment, for any reason, in each case in its sole discretion.

 

Establishment of Account; Use of Account. (a) After obtaining and verifying the necessary information as detailed above, RedWage will establish an account for Customer (“Account”). Customer will determine which of its employees it desires to be issued a Card and will provide the required information for each such employee (“Employee Application”). RedWage shall verify the information provided and approve or decline each individual Employee Application subject to the Issuing Bank’s and the Networks’ rules, and applicable laws. For each approved employee, RedWage will provide Customer with a bank routing number and direct deposit account number. RedWage will ship Cards directly to the mailing address of approved employees (“Cardholders”).Each Cardholder and Card will be subject to the terms and conditions of the Cardholder Agreement directly between the Cardholder and the Issuing Bank (the “Cardholder Agreement”), which will be delivered to the Cardholder along with the Card.

 

(b) Customer may periodically transfer funds owed or otherwise due to a Cardholder by depositing such funds to the Cardholder’s account through electronic funds transfer (“ETF”) via an Automated Clearing House (“ACH”). Customer is solely responsible for any and all funds transfers, including, but not limited to a determination of the amount, timing, recipients and compliance with tax and other applicable laws related thereto. After any such transfer, each Cardholder will have the ability to access its funds through designated ATMs, at merchants participating in the applicable Networks, and by other approved methods. Customer may enroll additional employees at any time upon verification and compliance with the terms and conditions of employee enrollment set forth herein. Customer agrees to comply with RedWage’s instructions for the implementation and usage of the Service, which operational instructions may be modified by RedWage from time to time.

 

	 	
2.5.

	
Removal of Enrolled Employee(s).Customer may, at any time and for any reason, such as employee termination or employee request, remove individual Cardholders from the Customer’s account. Customer understands and acknowledges that removal of Cardholder from the Customer Account does not constitute cancellation of the Cardholder’s card, and the Cardholder has the right to continued usage of the Card subject to the Card terms and conditions and the Cardholder Agreement.

	 	
2.6. 

	
Ownership of Cards. Customer acknowledges that the Cards are the property of the Issuing Bank, and shall be subject to cancellation at any time by the Issuing Bank, in accordance with this Agreement, the Cardholder Agreement or as required by applicable law, or, on a case-by-case basis, where the Issuing bank reasonably believes a Cardholder is using the Card for fraudulent or illegal purposes. Upon receipt of such notice from the Issuing Bank, RedWage shall notify the Customer via email and on the Customer Portal (as defined in Section 2.7 below).

	 	
2.7. 

	
Customer Portal. RedWage will provide Customer access to an electronic customer portal (“Customer Portal”), which may be utilized by the Customer for administration of Customer’s Account, to enroll new employees, to remove employees and to receive help electronically. Customer must use its own computer to access the Customer Portal. The Customer Portal shall provide Customer with access to Account information and employees enrolled in the Card program. Access IDs and passwords to the Customer Portal will only be issued to Authorized Representatives of Customer who have been designated in writing to access Customer’s Account. The Customer or its designated Authorized Representative may voluntarily change the Customer’s Access ID and password at any time. Customer is responsible for keeping the Access ID and passwords confidential and RedWage shall have no responsibility or liability for Customer maintaining the confidentiality or restricted use of the Access ID’s and passwords. The Customer Portal for the administration of the Customer’s Account can be found at www.pbprepaid.com.

 

  

2

  

	 	
2.8. 

	
Cardholder Privacy. Customer understands and acknowledges that the transaction activity of each Cardholder account is sensitive customer information protected under the law. RedWage and Customer represent and warrant that they each have a legal responsibility to keep sensitive customer information strictly confidential and to comply with applicable law with regard to privacy of sensitive customer information.

	 	
2.9.

	
Compliance. For purposes of this Agreement, the parties acknowledge and agree that the Card accounts are “payroll card accounts” as defined in Regulation E (12 CFR Part 205). RedWage will comply with Regulation E as it applies to RedWage and the payroll cards. To assist RedWage’s compliance efforts and to comply with applicable laws, Customer represents, warrants and covenants as follows: Customer will not distribute payroll to its employees via Cards without first obtaining each employee’s written consent to the use of the payroll Card using the Pay Card Consent Form, a copy of which is provided via the Customer Portal (or as an alternative, Customer may use a Customer created consent form that includes the content of the RedWage form). The Customer shall retain all original signed Consent Forms and provide copies to its employee’s. The Customer will also provide copies to RedWage upon RedWage’s request.

	
3. 

	
Term; Termination; Remedies

 

	 	
3.1. 

	
Term. This Agreement will become effective on the date this Agreement is accepted by RedWage (as documented via a written acceptance communication from RedWage, including but not limited to via email) and will continue for a period of three (3) years from such date (the “Initial Term”), unless earlier terminated pursuant to the terms hereof. This Agreement shall automatically renew at the end of the Initial Term for consecutive, successive renewal terms of one (1) year each unless and until one party provides written notice of non-renewal to the other party not less than ninety (90) days prior to the end of the then-existing renewal term.

	 	
3.2.

	
Immediate Termination. (a) This Agreement may be terminated immediately by either party in the event that the Networks prohibit the Service, the Issuing Bank ceases to be a Network member, the Issuing Bank ceases to be the Card issuer, or the Issuing Bank requires that the Agreement be terminated pursuant to the terms of RedWage’s Card Issuance Agreement with the Issuing Bank or if required by law; provided that, to the extent practical, RedWage shall endeavor to provide Customer with advance notice of any such event.

 

(b) Additionally, this Agreement may be terminated immediately by either party, upon written notice to the other party, in the event that the other Party (i) files a voluntary petition in bankruptcy or a petition seeking any reorganization, liquidation, dissolution, or similar relief under any applicable law relating to bankruptcy, insolvency, or relief for debtors, or the admission by such other party of its inability to pay debts as they mature, or the making by such other party of an assignment for the benefit of creditors or the taking of similar action for the benefit of creditors, or (ii) the entry by a court of competent jurisdiction of an order, judgment, or decree approving a petition filed against such other party seeking any reorganization, liquidation, dissolution, or similar relief under any applicable law relating to bankruptcy, insolvency, or other relief for debtors and the expiration of the period, if any, allowed by applicable law in which to appeal there from or (iii) materially violates any applicable law, rule, or regulation in connection with exercising its rights or meeting its obligations under this Agreement.

 

(c)Further, this agreement may be terminated immediately by RedWage if there has been no activity on Customer’s Account for a period of one year or longer.

 

	 	
3.3.

	
Cooperation upon Termination. Upon the termination of this Agreement for any reason, the parties agree to cooperate in good faith to wind down the program in a commercially reasonable way. Customer’s obligation to pay for all outstanding amounts incurred before the effective date of termination shall survive termination. Customer acknowledges that upon termination for any reason, the Customer can no longer order Cards, and the existing Cards stay in effect, unless the Cardholder makes a cancellation election pursuant to the terms of the Cardholder Agreement.

 

  

3

  

	 	
3.4.

	
Termination Rights for Payment Default. In the event of Customer’s failure to make any payment(s) when due under this Agreement, RedWage shall have the right to suspend further Service until payment is made in full, and if payment is not made in full within a reasonable period of time, not to exceed 45 days, then RedWage may thereafter terminate this Agreement, and be entitled to all rights and remedies hereunder.

	 	
3.5.

	
Termination Rights - Other Defaults. In the event of any default under this Agreement by either party (other than those permitting immediate termination, or a payment default or jurisdictional termination covered elsewhere in this Agreement), the non-defaulting party shall provide the defaulting party written notice of the nature of the default. The defaulting party shall have thirty (30) days from the date of receipt of the written default notice to cure the default, and if the default is not cured within such time period, then the non-defaulting party may thereafter terminate this Agreement, without further elapsed time.

	 	
3.6. 

	
Termination in a Jurisdiction. In addition to any other rights of termination, either party may terminate this Agreement upon prior written notice to the other party with respect to any individual state or jurisdiction if the terminating party can demonstrate, with documentary support, that changes in applicable laws or regulations or the interpretation thereof will make the performance of such party’s obligations hereunder not commercially feasible; and provided, further, that the parties have previously discussed the issues in a good faith attempt to find a resolution that would permit the Agreement to remain in effect with respect to the state or jurisdiction in question. The effective date of a termination under this Section 3.6 will be ninety (90) days from the date notice is delivered, or upon the effective date of the new law or regulation, whichever occurs sooner.

	 	
3.7.

	
Remedies. Termination or expiration of this Agreement will not limit any other remedies available to either party, including injunctive relief, and will not relieve the Customer of its obligation to pay all fees and expenses that have accrued prior to termination or expiration or are otherwise owed by Customer to RedWage pursuant to this Agreement.

	 	
3.8. 

	
Survival Rights. All rights and obligations that by their nature are continuing, including but not limited to each party’s confidentiality and indemnification obligations, shall survive any termination or expiration of this Agreement.

	
4. 

	
Fees and Payment. In connection with the submission of this Agreement Customer is required to pay a one-time, non-refundable application fee as detailed in Exhibit A to this Agreement. In addition, upon acceptance of this Agreement by RedWage, Customer agrees to pay RedWage for the Service as set forth in Exhibit A and payment of such fees shall be made in accordance with the terms and conditions set forth in Exhibit A. RedWage may change the fees set forth in Exhibit A or add fees by providing thirty (30) days prior written notice to Customer. Customer acknowledges that in connection with entering into this Agreement (including payment of the applicable one-time, non-refundable application fee), Customer is providing valid credit card information and the related authorization. If any of Customer’s payments to RedWage, regardless of the form, are rejected for any reason, or are late or are returned, then Customer shall pay RedWage’s standard late payment and return payment fee in addition to any other rights or remedies RedWage may have under this Agreement.

 

  

4

  

	
5.

	
Customer Responsibilities.

	 	
5.1. 

	
Employee Verification. Customer is responsible for, and hereby represents, warrants and covenants that it has verified the legal identity of each prospective Cardholder (or will prior to requesting a Card for such employee and delivering an employee application).

	 	
5.2. 

	
Employee Education. Customer is responsible for providing each prospective Cardholder with the “About Your Card” information sheet and the schedule of the fees that the Cardholder may incur in connection with the Card prior to enrollment of the prospective Cardholder. Such information and additional informational materials can be found at www.smartwage.com, or at www.pbprepaid.com, or on the Customer Portal found at www.pbprepaid.com.

	 	
5.3. 

	
Illegal Activities. Customer may not use the Services for any activity that violates any applicable federal, state or local law, statute, ordinance or regulation or for any purposes other than for what the Service is intended.

	 	
5.4. 

	
Compliance with Laws Relating to Payroll and Related Matters. The Customer is solely responsible for compliance with all applicable federal, state and local laws, rules and regulations relating to payroll, compensation and employment matters, including, without limitation, proper withholding, and timely remittance of, any and all taxes related thereto (e.g., local, state and federal income, payroll or social security taxes) as applicable, and Customer agrees to indemnify and hold RedWage and its employees, agents and representatives harmless from any and all liabilities, including interest and penalties, which are or may be imposed on RedWage or any of its employees, agents and representatives pursuant to any such laws. Customer’s obligations under this Section 5.4 shall survive the termination or expiration of this Agreement, regardless of whether any such liabilities arise before or after the effective date of any such termination or expiration.

	 	
5.5. 

	
Security. Customer accepts full responsibility for maintaining the confidentiality of all login and/or Access IDs, passwords or other security codes and procedures (to access RedWage’s systems) that are in Customer’s or its employees, agent’s or representative’s possession or control. Customer shall notify RedWage immediately by telephone of any loss, theft, unauthorized use or fraudulent use of, login and/or Access IDs, passwords or other security codes or procedures and shall be fully responsible for the unauthorized or fraudulent use thereof; provided that any such fraud or misuse is not directly caused by RedWage. Additionally, Customer may not access RedWage’s system, including the Customer Portal, for any purposes other than administration of the Services and shall remain liable for any unauthorized access by any of its employees, agents or representatives. Customer is also solely responsible for the set-up, maintenance and security of Customer’s systems, including, but not limited to those used to access the Customer Portal or any other permissible online services of RedWage.

	
6.  

	
Representations and Warranties; Limitation of Liability.

	 	
6.1. 

	
Representations and Warranties of the Parties. Each of RedWage and Customer represents and warrants to the other that: (i) it has the right and authority to enter into and perform all of its respective obligations under this Agreement; (ii) it is and will remain during the term of this Agreement in material compliance with all applicable laws, statutes, ordinances, rules and regulations with respect to its performance under this Agreement; (iii) no authorization or approval from any third party is or will be required in connection with such party’s entering into, delivery or performance of this Agreement; and (iv) neither entering into this Agreement, nor the performance of this Agreement violate or conflict with the terms or conditions of any other agreement to which it is a party or by which it is bound. In addition, Customer represents and warrants to RedWage that it is not engaged in any criminal activity such as money laundering, illegal trafficking or other activity.

 

  

5

  

	 	
6.2. 

	
Disclaimer of Warranties. EXCEPT AS EXPRESSLY SET FORTH INTHIS AGREEMENT, REDWAGE SPECIFICALLY DISCLAIMS ALL WARRANTIES OF ANY KIND, EXPRESS OR IMPLIED, ARISING OUT OF OR RELATED TO THIS AGREEMENT, INCLUDING, WITHOUT LIMITATION, THAT THE OPERATION OF THE PRODUCTS, SERVICES OR SYSTEMS WILL BE UNINTERUPTED OR ERROR-FREE, OR THAT ALL ERRORS WILL BE CORRECTED, OR ANY WARRANTY OF MARKETABILITY, FITNESS FOR A PARTICULAR PURPOSE OR NON-INGRINGEMENT, AND IMPLIED WARANTIES ARISING FROM COURSE OF DEALING OR COURSE OF PERFORMANCE, EACH OF WHICH IS HEREBY EXCLUDED BY AGREEMENT OF THE PARTIES.

	 	
6.3. 

	
No Special Damages. IN NO EVENT WILL EITHER PARTY BE LIABLE TO THE OTHER PARTY WHETHER IN CONTRACT, TORT, EQUITY OR OTHERWISE FOR ANY INDIRECT, INCIDENTAL, CONSEQUENTIAL, SPECIAL, PUNITIVE OR EXEMPLARY DAMAGES, EVEN IF SUCH PARTY HAS KNOWLEDGE OF THE POSSIBILITY OF SUCH DAMAGES AND NOTWITHSTANDING ANY FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY.

	 	
6.4. 

	
Limitation of Liability. EXCEPT FOR ANY LIABILITY FOR MATERIAL BREACH OF SECTION 6.5 HEREOF, IN NO EVENT WILL REDWAGE BE LIABLE TO CUSTOMER FOR AGGREGATE DAMAGES IN EXCESS OF THE FEES PAID TO REDWAGE DURING THE MOST RECENT TWELVE CALENDAR MONTH PERIOD.

	 	
6.5. 

	
Confidentiality. RedWage and Customer agree and covenant to each other that they shall not, during the performance of this Agreement or at any time after the termination or expiration hereof, use or disclose to any third party other than during the proper performance of their duties hereunder, (a) the rates, terms and conditions of this Agreement, and (b) the Confidential and Proprietary Information of the other party hereto. For purposes of this Agreement, “Confidential and Proprietary Information” shall include, but not be limited to technical information, procedures, practices, confidential dealings of the other party hereto, all RedWage reports provided to Customer, and other confidential, non-public business information of a party provided by such party to the other pursuant to this Agreement. The parties agree to use the same degree of care in protecting the other party’s Confidential and Proprietary Information as they do their own such information, but in no event less than a reasonable degree of care. The obligations of this Section shall not apply to information that (a) is or becomes publicly known through legal means without fault by the other party, (b) was known to, or in the rightful possession of the other party prior to its disclosure and such prior knowledge or rightful possession can be documented, or (c) is independently developed by a party without use or reference to the other party’s Confidential and Proprietary Information, or is rightly obtained from a source other than the other party. The restrictions in this Section 6.5 regarding disclosure shall not apply to those disclosures required by law (i.e. subpoena or other court order); provided, however that the party required to disclose pursuant to applicable law shall provide the other party prompt written notice of its obligation to disclose in order to permit such other party to take whatever steps it deems necessary to protect the confidentiality of its information. Notwithstanding the foregoing, RedWage is permitted to solicit, market and provide other products and services to the Cardholders and use of Cardholder information (excluding sensitive customer information as defined by law) for such purposes is specifically permitted and does not violate the restrictions in this Section 6.5.

	 	
6.6. 

	
Liability for Acts of Employees and Agents. Each party agrees to indemnify and hold harmless the other party and its employees, agents and representatives from any and all claims for damages, losses or liabilities (including reasonable attorneys fees and court costs) arising out of or relating to disputes or legal actions with third parties concerning the willful acts or omissions of any employees, agents or representatives of such party, or from the material breach by such party of its obligations under this Agreement. For purposes hereof, any person who is given authorization by Customer to use Cards, codes, passwords or other security codes or procedures shall be deemed an employee, agent or representative of Customer.

	 	
6.7.

	
Force Majeure. In no event shall either party be liable for failure to fulfill its obligations hereunder due to causes beyond its reasonable control, including, but not limited to, acts or omissions of government or military authority, acts of God (including earthquakes and floods), acts of terrorism, fires, explosions, strikes, riots, actions of the Networks or regulatory bodies controlling the Networks which significantly inhibit or prohibit the Services, third party telecommunications failures (including any systemic Internet failures and any interruptions in services of Internet service providers, but not any failures or interruptions that could have been avoided by the exercise of reasonable care), transportation delays, or wars.

 

  

6

  

	
7. 

	
General Provisions.

	 	
7.1.

	
 Independent Contractors. None of the provisions of this Agreement are intended to create nor shall be deemed or construed to create any relationship between the parties hereto other than that of independent entities contracting with each other hereunder solely for the purpose of effecting the provisions of this Agreement. Neither of the parties hereto, nor any of their respective employees, shall be construed to be the employer of the other. Customer and RedWage agree that RedWage is only providing services under this Agreement as an independent contractor.

	 	
7.2. 

	
Compliance with Laws. Each party shall comply in all material respects with all applicable federal, state and local laws and regulations in the performance of their respective obligations under this Agreement.

	 	
7.3. 

	
Notices. All written notices required to be given by this Agreement shall be deemed to be duly given if delivered personally or sent by registered or certified U.S. mail, facsimile (with return confirmation of receipt via one of the other methods) or reputable overnight courier to (a) RedWage at RedWage PO Box 1214, Summit, NJ 07902, attn: Legal, or to (b) Customer at such address provided to RedWage in its Customer Application. Such notice shall be deemed duly given the day of personal delivery, three (3) days after being sent via registered or certified mail, the business day of facsimile if return confirmation of receipt is given via one of the other methods within 3 days of such facsimile transmission, or the business day after deposit with such reputable overnight courier. Notwithstanding the foregoing, if another means of providing notice is specifically set forth elsewhere in this Agreement, such method and time period for notice shall apply to that particular section.

	 	
7.4. 

	
Press Releases, Publicity, Etc. Neither party shall issue any press release or disseminate similar publicity or other information regarding this Agreement or the Service for Customer or utilizing the trademarks, service marks, trade names or logos of Customer, RedWage, Issuing Bank or the Networks, including, without limitation, web site information instructional or marketing materials or brochures, without the express prior written approval of Customer, RedWage, Issuing Bank or the Networks, as appropriate.

	 	
7.5. 

	
Miscellaneous. This Agreement shall be governed by the laws of the State of New Jersey, without regard to the choice of law rules of such state. Customer agrees and consents to the exclusive jurisdiction of the state and federal courts of the State of New Jersey in connection with any action or proceeding regarding or relating to this Agreement, and the Customer hereby waives any objections to such jurisdiction or venue. Should any part of this Agreement be held invalid or unenforceable, in any respect, such invalidity or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if such provision(s) had never been contained herein, provided, that such provision(s) shall be curtailed, limited or eliminated only to the extent necessary to remove the invalidity or unenforceability. The prevailing party in any action or proceeding to interpret or enforce this Agreement shall be entitled to recover its reasonable attorney’s fees, costs and expenses. Upon RedWage’s reasonable request, Customer agrees to promptly complete and deliver such further documents as necessary or appropriate related to providing the Service. Failure to insist upon strict compliance with any of the terms or conditions of this Agreement shall not be deemed a waiver of such term or condition, nor shall any waiver or relinquishment of any right or power hereunder at any time or times be deemed a subsequent waiver or relinquishment of such right or power. The section headings contained in this Agreement are for reference purposes only and shall not affect the meaning or interpretation of this Agreement. This Agreement, together with the exhibits hereto which are incorporated herein by reference, constitutes the entire agreement of the parties relating to this subject matter and supersedes all prior or contemporaneous agreements and understandings regarding the subject matter hereof, whether written or verbal. In the event of any future changes to laws, regulations or the interpretation thereof or changes in RedWage’s operational procedures, which changes impact RedWage’s provision of Services, RedWage will notify Customer in writing via email, a notice on the Customer Portal, or other commercially reasonable methods, of the changes as well as any modifications required as a result thereof. Unless Customer objects to such modifications in writing within 30 days of receipt of notice thereof, Customer will be deemed to have accepted such modifications. Except as expressly set forth in this Agreement, this Agreement may only be modified by a writing signed by both parties. This Agreement shall be binding on the parties and their respective successors and assigns. Notwithstanding the foregoing, this Agreement may not be assigned, in whole or in part, by Customer without the prior written consent of RedWage, and any attempted assignment without such prior consent shall be null and void.

	 	
7.6.

	
Electronic Execution. Customer acknowledges and agrees that this Agreement is being entered into and submitted electronically and that no separate hard copy will be provided. In addition, Customer and RedWage agree that electronic records and signatures and facsimile copies of signatures shall have the full legal effect of a writing.

By clicking “Submit”, Customer hereby acknowledges and agrees that it will be legally bound to the terms and conditions of this Agreement, subject to the acceptance by RedWage.

 

  

7

  

 

EXHIBIT A

 

	
·

	
SmartWage Payroll Program One-Time, Non-Refundable Application Fee: $25.00 USD

 

	
·

	
Card Acquisition Fee: $5.00 USD per card

The SmartWage Payroll Program One-Time, Non-Refundable Application Fee is due upon submission of this Agreement and the Customer Application. This Fee is non-refundable, regardless of whether this Agreement is accepted or rejected by RedWage.

The SmartWage Payroll Program Enrollment Fee is due upon acceptance of this Agreement by RedWage.

The Card Acquisition Fee is due upon each individual Card issuance for new employee enrollment.

All Fees are to be paid by use of Customer’s credit card. Upon submission of this Agreement, Customer must also provide valid credit card information and related authorization(s). All Fees will be paid via the Customer credit card, and will be made simultaneously with the election of Services under this Agreement through the Customer Portal or otherwise.

 

 

8

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00221-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00221-of-00352.parquet"}]]