Document:

kldo-ex101_34.htm

Exhibit 10.1

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY [***], HAS BEEN OMITTED BECAUSE IT IS NOT MATERIAL AND WOULD LIKELY CAUSE COMPETITIVE HARM TO THE COMPANY IF PUBLICLY DISCLOSED.

 

THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT

THIS THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”), dated as of April 30, 2021 (the “Amendment Effective Date”), is made among Kaleido Biosciences, Inc., a Delaware corporation, and each of its Qualified Subsidiaries (including Cadena Bio, Inc., a Delaware corporation) (collectively, jointly and severally, “Borrower”), the several banks and other financial institutions or entities from time to time parties to the Loan Agreement (as defined below) (collectively, the “Lenders”) and Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent and collateral agent for itself and the Lenders (in such capacity, “Agent”).

Borrower, the Lenders and Agent are parties to that certain Loan and Security Agreement, dated as of December 31, 2019, as amended by that certain First Amendment to Loan and Security Agreement, dated as of April 10, 2020 and that certain Second Amendment to Loan and Security Agreement, dated as of June 15, 2020 (the “Existing Loan Agreement”; and the Existing Loan Agreement, as amended by this Amendment and as further amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”). Borrower has requested that Agent and the Lenders agree to certain amendments to the Existing Loan Agreement.  Agent and the Lenders have agreed to such request, subject to the terms and conditions hereof.

Accordingly, the parties hereto agree as follows:

SECTION 1Definitions; Interpretation.

(a)Terms Defined in Loan Agreement.  All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise defined herein shall have the meanings assigned to them in the Loan Agreement.

(b)Rules of Construction.  The rules of construction that appear in the last paragraph of Section 1.3 of the Loan Agreement shall be applicable to this Amendment and are incorporated herein by this reference.

SECTION 2Amendments to the Loan Agreement.

(a)Upon satisfaction of the conditions set forth in Section 3 hereof, the Existing Loan Agreement is hereby amended as follows:

(i)New Definition.  The following definition is added to Section 1.1 in its proper alphabetical order:

“Third Amendment Effective Date” means April 30, 2021.

(ii)Amended Definitions.  The following definitions are hereby amended and restated as follows:

“Amortization Date” means February 1, 2022.

“Maximum Term Loan Amount” means Forty Million and No/100 Dollars ($40,000,000.00).

(iii)Recitals.  Recital A is hereby amended and restated as follows:

 

US-DOCS\116262561.7

“Borrower has requested the Lenders make available to Borrower a loan in an aggregate principal amount of up to Forty Million Dollars ($40,000,000.00) (the “Term Loan”); and”

(iv)Section 2.2. Section 2.2(a) is hereby amended and restated as follows:

“(a)Advances. Subject to the terms and conditions of this Agreement, the Lenders will severally (and not jointly) make in an amount not to exceed its respective Term Commitment, and Borrower agrees to draw, a Term Loan Advance of Twenty-Two Million Five Hundred Thousand Dollars ($22,500,000) on the Closing Date (the “Tranche 1 Advance”). Subject to the terms and conditions of this Agreement, beginning on the Third Amendment Effective Date and continuing through June 1, 2021, Borrower may request, and the Lenders shall severally (and not jointly) make, an additional Term Loan Advance in a principal amount of Five Million Dollars ($5,000,000) (the “Tranche 2 Advance”).  Subject to the terms and conditions of this Agreement, and conditioned on approval by the Lenders’ investment committee in its sole and unfettered discretion, on or before December 15, 2021, Borrower may request an additional Term Loan Advance in a principal amount up to Twelve Million Five Hundred Thousand Dollars ($12,500,000) (the “Tranche 3 Advance”).  The aggregate outstanding Term Loan Advances may be up to the Maximum Term Loan Amount.

(v)Section 7.20.  Section 7.20 is hereby amended and restated as follows:

	
 
	
“7.20
	
Financial Covenant (Minimum Cash).  Beginning on the Third Amendment Effective Date, Borrower shall, at all times, maintain Qualified Cash in an amount greater than or equal to Fifteen Million Dollars ($15,000,000) plus the Qualified Cash A/P Amount; provided, however, that in the event Borrower achieves Performance Milestone III, beginning immediately after such achievement, Borrower shall, at all times, maintain Qualified Cash in an amount greater than or equal to the sum of Five Million Dollars ($5,000,000) plus the Qualified Cash A/P Amount.

Borrower shall provide Agent evidence of compliance with this Section 7.20 in each Compliance Certificate and upon request in form and substance reasonably acceptable to Agent, along with supporting documentation reasonably requested by Agent.”

(vi)Compliance Certificate.  Exhibit E (Compliance Certificate) is hereby amended and restated in its entirety as set forth in Annex A hereto.

(vii)Schedule 1.1.  Schedule 1.1 is hereby amended and restated in its entirety as set forth in Annex B hereto.

(b)References Within Existing Loan Agreement.  Each reference in the Existing Loan Agreement to “this Agreement” and the words “hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a reference to the Existing Loan Agreement as amended by this Amendment.  

SECTION 3Conditions of Effectiveness.  The effectiveness of Section 2 of this Amendment shall be subject to the satisfaction of each of the following conditions precedent: 

(a)Fees and Expenses.  Borrower shall have paid Agent (i) an amendment fee of $20,000, (ii) all reasonable invoiced costs and expenses then due in accordance with Section 5(e), and (iii) all other reasonable invoiced fees, costs and expenses, if any, due and payable as of the Amendment Effective Date under the Loan Agreement.

(b)This Amendment.  Agent shall have received this Amendment, executed by Agent, the Lenders and Borrower.

(c)Representations and Warranties; No Default.  On the Amendment Effective Date, after giving effect to the amendment of the Loan Agreement contemplated hereby:

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(i)The representations and warranties contained in Section 4 shall be true and correct on and as of the Amendment Effective Date as though made on and as of such date; and

(ii)There exist no Events of Default or events that with the passage of time would result in an Event of Default.

SECTION 4Representations and Warranties.  To induce Agent and the Lenders to enter into this Amendment, Borrower hereby confirms, as of the date hereof, (a) that the representations and warranties made by it in Section 5 of the Loan Agreement and in the other Loan Documents are true and correct in all material respects; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; provided, further, that to the extent such representations and warranties by their terms expressly relate only to a prior date such representations and warranties shall be true and correct as of such prior date, and that no Event of Default has occurred and is continuing; (b) other than as updated on Annex C attached hereto, that the information included in the Perfection Certificate delivered to Agent on the Second Amendment Effective Date remains true and correct in all material respects; (c) Agent has and shall continue to have valid, enforceable and perfected first-priority liens, subject only to Permitted Liens, on and security interests in the Collateral and all other collateral heretofore granted by Borrower to Agent, pursuant to the Loan Documents or otherwise granted to or held by Agent; (d) the agreements and obligations of Borrower contained in the Loan Documents and in this Amendment constitute the legal, valid and binding obligations of Borrower, enforceable against Borrower in accordance with their respective terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or other similar laws of general application affecting the enforcement of creditors’ rights or by the application of general principles of equity; and (e) the execution, delivery and performance of this Amendment by Borrower will not violate any law, rule, regulation, order, contractual obligation or organizational document of Borrower and will not result in, or require, the creation or imposition of any lien, claim or encumbrance of any kind on any of its properties or revenues.  For the purposes of this Section 4, each reference in Section 5 of the Loan Agreement to “this Agreement,” and the words “hereof,” “herein,” “hereunder,” or words of like import in such Section, shall mean and be a reference to the Existing Loan Agreement as amended by this Amendment. 

SECTION 5Miscellaneous.

(a)Loan Documents Otherwise Not Affected; Reaffirmation; No Novation.  

(i)Except as expressly amended pursuant hereto or referenced herein, the Loan Agreement and the other Loan Documents shall remain unchanged and in full force and effect and are hereby ratified and confirmed in all respects.  The Lenders’ and Agent’s execution and delivery of, or acceptance of, this Amendment shall not be deemed to create a course of dealing or otherwise create any express or implied duty by any of them to provide any other or further amendments, consents or waivers in the future.  

(ii)Borrower hereby expressly (1) reaffirms, ratifies and confirms its Secured Obligations  under the Loan Agreement and the other Loan Documents, (2) reaffirms, ratifies and confirms the grant of security under Section 3.1 of the Loan Agreement, (3) reaffirms that such grant of security in the Collateral secures all Secured Obligations under the Loan Agreement, and with effect from (and including) the date hereof, such grant of security in the Collateral: (x) remains in full force and effect notwithstanding the amendments expressly referenced herein; and (y) secures all Secured Obligations under the Existing Loan Agreement, as amended by this Amendment, and the other Loan Documents, (4) agrees that this Amendment shall be a “Loan Document” under the Loan Agreement and (5) agrees that the Loan Agreement and each other Loan Document shall remain in full force and effect following any action contemplated in connection herewith.

(iii)This Amendment is not a novation and the terms and conditions of this Amendment shall be in addition to and supplemental to all terms and conditions set forth in the Loan Documents. Nothing in this Amendment is intended, or shall be construed, to constitute an accord and satisfaction of Borrower’s Secured Obligations under or in connection with the Loan Agreement and any other Loan Document or to modify, affect or impair the perfection or continuity of Agent’s security interest in, (on behalf of itself and the Lenders) security titles to or other liens on any Collateral for the Secured Obligations.

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(b)Conditions.  For purposes of determining compliance with the conditions specified in Section 3, each Lender that has signed this Amendment shall be deemed to have consented to, approved or accepted or to be satisfied with, each document or other matter required thereunder to be consented to or approved by or acceptable or satisfactory to a Lender unless Agent shall have received notice from such Lender prior to the date hereof specifying its objection thereto.

(c)Release.  In consideration of the agreements of Agent and each Lender contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, each Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby fully, absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each Lender, and its successors and assigns, and its present and former shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives (Agent, the Lenders and all such other persons being hereinafter referred to collectively as the “Releasees” and individually as a “Releasee”), of and from all demands, actions, causes of action, suits, covenants, contracts, controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever of every name and nature, known or unknown, suspected or unsuspected, both at law and in equity, which any Borrower, or any of its successors, assigns, or other legal representatives may now or hereafter own, hold, have or claim to have against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or thing whatsoever which arises at any time on or prior to the day and date of this Amendment, including, without limitation, for or on account of, or in relation to, or in any way in connection with the Loan Agreement, or any of the other Loan Documents or transactions thereunder or related thereto.  

Each Borrower understands, acknowledges and agrees that the release set forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit or other proceeding which may be instituted, prosecuted or attempted in breach of the provisions of such release.  Each Borrower agrees that no fact, event, circumstance, evidence or transaction which could now be asserted or which may hereafter be discovered shall affect in any manner the final, absolute and unconditional nature of the release set forth above. Each Borrower waives the provisions of California Civil Code Section 1542, which states: 

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS THAT THE CREDITOR OR RELEASING PARTY DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE AND THAT, IF KNOWN BY HIM OR HER, WOULD HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR OR RELEASED PARTY.

The provisions of this section shall survive payment in full of the Secured Obligations, full performance of all the terms of this Amendment and the other Loan Documents.

(d)No Reliance.  Each Borrower hereby acknowledges and confirms to Agent and the Lenders that such Borrower is executing this Amendment on the basis of its own investigation and for its own reasons without reliance upon any agreement, representation, understanding or communication by or on behalf of any other Person.

(e)Costs and Expenses.  Each Borrower agrees to pay to Agent the date hereof the reasonable invoiced out-of-pocket costs and expenses of Agent and each Lender party hereto, and the reasonable invoiced out-of-pocket fees and disbursements of counsel to Agent and each Lender party hereto (including allocated costs of internal counsel), in connection with the negotiation, preparation, execution and delivery of this Amendment and any other documents to be delivered in connection herewith on the date hereof.

(f)Binding Effect.  This Amendment binds and is for the benefit of the successors and permitted assigns of each party.  

(g)Performance Milestone II.  Borrower, Agent and Lenders agree that, as of the date hereof, Performance Milestone II is deemed to have been satisfied.

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(h)Governing Law.  This Amendment and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of the State of California, excluding conflict of laws principles that would cause the application of laws of any other jurisdiction.

(i)Complete Agreement; Amendments.  This Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements with respect to such subject matter.  All prior agreements, understandings, representations, warranties, and negotiations between the parties about the subject matter of this Amendment and the Loan Documents merge into this Amendment and the Loan Documents.  

(j)Severability of Provisions.  Each provision of this Amendment is severable from every other provision in determining the enforceability of any provision.

(k)Counterparts.  This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment.  Delivery of an executed counterpart of a signature page of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission will be as effective as delivery of a manually executed counterpart hereof.

(l)Loan Documents. This Amendment and the documents related thereto shall constitute Loan Documents.

(m)Electronic Execution of Certain Other Documents.  The words “execution,” “execute”, “signed,” “signature,” and words of like import in or related to any document to be signed in connection with this Agreement and the transactions contemplated hereby (including without limitation assignments, assumptions, amendments, waivers and consents) shall be deemed to include electronic signatures, the electronic matching of assignment terms and contract formations on electronic platforms approved by Agent, or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce Act, the California Uniform Electronic Transaction Act, or any other similar state laws based on the Uniform Electronic Transactions Act.

[remainder of page intentionally left blank]

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IN WITNESS WHEREOF, the parties hereto have duly executed this Amendment, as of the date first above written.

BORROWER:

KALEIDO BIOSCIENCES, INC.

Signature:_______________________

Print Name:

Title: 

CADENA BIO, INC.

Signature:_______________________

Print Name:

Title: 

 [SIGNATURES CONTINUE ON THE NEXT PAGE]

[Signature Page to Third Amendment to Loan and Security Agreement]

 

AGENT:

HERCULES CAPITAL, INC.

Signature:_______________________

Print Name:Jennifer Choe

Title:Associate General Counsel

 

LENDERS:

HERCULES CAPITAL, INC.

Signature:_______________________

Print Name:Jennifer Choe

Title:Associate General Counsel

HERCULES Funding iv llc

Signature:_______________________

Print Name:Jennifer Choe

Title:Associate General Counsel

 

 

 

 

[Signature Page to Third Amendment to Loan and Security Agreement]

Annex A

 

EXHIBIT E

COMPLIANCE CERTIFICATE

Hercules Capital, Inc. (as “Agent”)
400 Hamilton Avenue, Suite 310
Palo Alto, CA 94301

Reference is made to that certain Loan and Security Agreement dated as of December 31, 2019 and the Loan Documents (as defined therein) entered into in connection with such Loan and Security Agreement all as may be amended from time to time (hereinafter referred to collectively as the “Loan Agreement”) by and among Hercules Capital, Inc. (the “Agent”), the several banks and other financial institutions or entities from time to time party thereto (collectively, the “Lender”) and Kaleido Biosciences, Inc. (the “Company”) and each of its Qualified Subsidiaries, as Borrower. All capitalized terms not defined herein shall have the same meaning as defined in the Loan Agreement.

The undersigned is an Officer of the Company, knowledgeable of all Company financial matters, and is authorized to provide certification of information regarding the Company; hereby certifies, in such capacity and not in his individual capacity, that in accordance with the terms and conditions of the Loan Agreement, the Company is in compliance for the period ending ___________ of all covenants, conditions and terms and hereby reaffirms that all representations and warranties contained therein are true and correct in all material respects (to the extent not already qualified by materiality) on and as of the date of this Compliance Certificate with the same effect as though made on and as of such date, except to the extent such representations and warranties expressly relate to an earlier date, after giving effect in all cases to any standard(s) of materiality contained in the Loan Agreement as to such representations and warranties.  Attached are the required documents supporting the above certification.  The undersigned further certifies that the attached financial statements are prepared in accordance with GAAP (except for the absence of footnotes with respect to unaudited financial statement and subject to normal year-end adjustments) and are consistent from one period to the next except as explained below.

			
	
REPORTING REQUIREMENT
	
REQUIRED
	
CHECK IF ATTACHED

	
Interim Financial Statements 
	
Monthly within 30 days
	
 

	
Interim Financial Statements 
	
Quarterly within 45 days
	
 

	
Audited Financial Statements 
	
FYE within 90 days
	
 

 

ACCOUNTS OF BORROWER AND ITS SUBSIDIARIES AND AFFILIATES

The undersigned hereby also confirms the below disclosed accounts represent all depository accounts and securities accounts presently open in the name of each Borrower or Borrower’s Subsidiary, as applicable.

Each new account that has been opened since delivery of the previous Compliance Certificate is designated below with a “*”.

							
	
 
	
 
	
Depository AC #
	
Financial Institution
	
Account Type (Depository / Securities)
	
Last Month Ending Account Balance
	
Purpose of Account

	
BORROWER Name/Address:
	
 

	
 
	
1
	
 
	
 
	
 
	
 
	
 

	
2
	
 
	
 
	
 
	
 
	
 

	
3
	
 
	
 
	
 
	
 
	
 

	
4
	
 
	
 
	
 
	
 
	
 

	
5
	
 
	
 
	
 
	
 
	
 

	
6
	
 
	
 
	
 
	
 
	
 

	
7
	
 
	
 
	
 
	
 
	
 

	
 

	
BORROWER’S SUBSIDIARY Name/Address
	
 

	
 
	
1
	
 
	
 
	
 
	
 
	
 

	
2
	
 
	
 
	
 
	
 
	
 

	
3
	
 
	
 
	
 
	
 
	
 

	
4
	
 
	
 
	
 
	
 
	
 

	
5
	
 
	
 
	
 
	
 
	
 

	
6
	
 
	
 
	
 
	
 
	
 

	
7
	
 
	
 
	
 
	
 
	
 

	
 

 

 

 

 

To the extent applicable, the undersigned hereby confirms that the Borrowers are in compliance with Section 7.20 of the Loan Agreement (as applicable, attached as [Schedule A-1][Schedule A-2] hereto are the required calculations supporting this certification(s)), as of the date first set forth above.

Very Truly Yours,

KALEIDO BIOSCIENCES, INC.

	
 
	
By:
	
____________________________

Name:   _____________________________

	
 
	
Its:
	
____________________________

 

 

 

Schedule A-1 to Compliance Certificate

Effective as of the Third Amendment Effective Date:

			
	
(1)
	
Sum of Cash held by Borrower in accounts in the United States subject to an Account Control Agreement in favor of Agent:
	
$____________________

	
(2)
	
Sum of the Borrower’s accounts payable under GAAP not paid after the 90th day following the invoice date for such account payable:
	
$____________________

	
(3)
	
Sum of line (2) plus $15,000,000
	
$____________________

	
 
	
Is the amount in line (1) greater than or equal to the amount in line (3)?
	
 

YES – In compliance

NO – Not in compliance

 

 

 

 

Schedule A-2 to Compliance Certificate

If 

A. Performance Milestone III has been achieved, then

			
	
(1)
	
Sum of Cash held by Borrower in accounts in the United States subject to an Account Control Agreement in favor of Agent:
	
$____________________

	
(2)
	
Sum of the Borrower’s accounts payable under GAAP not paid after the 90th day following the invoice date for such account payable:
	
$____________________

	
(3)
	
Sum of line (2) plus $5,000,000
	
$____________________

	
 
	
B. Is the amount in line (1) greater than or equal to the amount in line (3)?
	
 

YES – In compliance

NO – Not in compliance

 

 

 

 

 

SCHEDULE 1.1

COMMITMENTS

			
	
LENDER
	
TRANCHE
	
TERM COMMITMENT

	
Hercules Funding IV LLC
	
Tranche 1
	
$22,500,000

	
Hercules Capital, Inc.
	
Tranche 2
	
$5,000,000

	
Hercules Capital, Inc.
	
Tranche 3
	
$12,500,000*

	
TOTAL COMMITMENTS
	
 
	
$40,000,000.00*

* Funding of Tranche 3 is subject to approval by Lender’s investment committee in its sole discretion.

 

 

Annex B

 

Updates to Perfection Certificate

[***]Document

Exhibit 10.1

2ND AMENDMENT 

TO THE

LICENSE AND COLLABORATION AGREEMENT

by and between

DAIICHI SANKYO EUROPE GMBH

and

ESPERION THERAPEUTICS, INC.

March 19th, 2021

This 2nd AMENDMENT to the LICENSE    AND COLLABORATION AGREEMENT (this “2nd Amendment”), entered into as of March 19th, 2021 (“2nd Amendment Effective Date”), is by and between Daiichi Sankyo Europe GmbH, a corporation organized and existing under the laws of Germany (“DSE”) and Esperion Therapeutics, Inc., a corporation organized and existing under the laws of the state of Delaware (“Esperion”).

Reference is hereby made to the License and Collaboration Agreement by and between DSE and Esperion, dated effective as of January 2, 2019, and to the 1st Amendment to the License and Collaboration Agreement, dated effective as of June 18, 2020 (collectively, as may be amended from time to time, the “LCA”). Capitalized terms not otherwise defined in this 2nd Amendment shall have the meanings set forth in the LCA. DSE and Esperion are sometimes referred to herein individually as a “Party” and collectively as the “Parties”.

WHEREAS, the LCA does not contain detailed provisions on how to handle domain names for Licensed Product in the DSE Territory and Esperion and DSE desire to enter into this 2nd Amendment to amend the LCA in order to clarify each Party’s rights and obligations with respect to the registration and maintenance of domain name(s) for use in connection with the Commercialization of Licensed Product in the DSE Territory. For the avoidance of doubt, such “domain name(s)” includes both, “branded domain name(s)” (containing Esperion Trademarks) and “unbranded domain name(s)” (without Esperion Trademarks, e.g. sites for disease awareness) (collectively, the “Bempe Domain(s)”).
 
NOW, THEREFORE, in consideration of the mutual covenants and conditions contained herein, the Parties, intending to be legally bound, hereby agree to amend the LCA as of the 2nd Amendment Effective Date as follows:

1.Bempe Domain(s) as of the Effective Date. All Bempe Domain(s) as of the 2nd Amendment Effective Date are listed in Annex 1, attached hereto and incorporated herein by reference, which Annex 1 may be amended by the Parties from time to time in accordance with the LCA.

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2.Ownership of Branded Domain Name(s): Esperion shall register, own and maintain at its sole cost and expense all the branded domain name(s) listed in Annex 1 and any additional branded domain name(s) mutually agreed to by the Parties in writing for use in connection with the Commercialization of the License Product in the DSE Territory. Notwithstanding the foregoing, DSE or its Affiliate may continue to own and maintain the branded domain name(s) registered by DSE before the 2nd Amendment Effective Date, which branded domains are listed in Annex 1, and DSE may register, own and maintain such mutually agreed to branded domain name(s) that Esperion is not able to register due to local regulation restrictions (as the case may be) (collectively, the “DSE Branded Domain Name(s)”).

3.Ownership of Unbranded Domain Name(s): DSE shall register, own and maintain at its sole cost and expense all the unbranded domain name(s) listed in Annex 1 and any additional unbranded domain(s) mutually agreed to by the Parties in writing for the Commercialization of the License Product in the DSE Territory. Notwithstanding the foregoing, Esperion or its Affiliate may register, own and maintain such mutually agreed to unbranded domain name(s) that DSE is not able to register due to local regulation restrictions (as the case may be) (collectively, the “Esperion Unbranded Domain Name(s)”).

4.Reimbursement of Certain Costs and Expenses:

4.1 Any reasonable, documented out-of-pocket costs and expenses (without markup) incurred by DSE, whether incurred prior to or after the 2nd Amendment Effective Date, relating to the registration and maintenance of the DSE Branded Domain Name(s) will be reimbursed by Esperion to DSE within thirty (30) days from the receipt of an invoice therefor, which amount with respect to DSE Branded Domain Name(s) registered by DSE prior to the 2nd Amendment Effective Date is USD 4,756.15. For clarity, DSE may not register branded domain name(s), except in accordance with paragraph 2 above.

4.2. Any reasonable, documented out-of-pocket costs and expenses (without markup) incurred by Esperion after the 2nd Amendment Effective Date relating to the registration and maintenance of the Esperion Unbranded Domain Name(s) will be reimbursed by DSE to Esperion within thirty (30) days from the receipt of an invoice therefore.

5.Term. This 2nd Amendment shall be effective as of the 2nd Amendment Effective Date and remain in force until the expiration or the termination of the LCA.

6.Effects of Termination or Expiration: DSE Branded Domain Name(s). Effective upon the expiration or the termination of the LCA, DSE will (and will cause its Affiliates to) assign and hereby assigns to Esperion or its designee any DSE Branded Domain Name(s) owned by DSE or its Affiliates as of the effective date of such expiration or termination, including, without limitation, the DSE Branded Domain Name(s) listed in Annex 1, if requested by Esperion and permissible under applicable Laws. Where such assignment of DSE Branded Domain Name(s) is not permissible under applicable Laws, e.g. due to local regulation restrictions (as the case may be), DSE will (and will cause its Affiliates to) immediately cease the use of such DSE Branded Domain Name(s). DSE will (and will cause its Affiliates to) cooperate with Esperion to effectuate the foregoing assignment, including by promptly executing any documents necessary to effectuate such assignment. Any reasonable, documented out-of-pocket costs and expenses 
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(without markup) incurred by DSE or its Affiliates in connection with the assignment of the DSE Branded Domain Name(s) owned by DSE or its Affiliates to Esperion will be reimbursed by Esperion to DSE within thirty (30) days from receipt of an invoice therefore.

7.Effects of Termination or Expiration: Esperion Unbranded Domain Name(s). Effective upon the expiration or the termination of the LCA, Esperion will assign and hereby assigns to DSE or its designee any Esperion Unbranded Domain Name(s) owned by Esperion as of the effective date of such expiration or termination, if requested by DSE and permissible under applicable Laws. Where such assignment of Esperion Unbranded Domain Name(s) is not permissible under applicable Laws, e.g. due to local regulation restrictions (as the case may be), Esperion will immediately cease the use of such Esperion Unbranded Domain Name(s). Esperion will cooperate with DSE to effectuate the foregoing assignment, including by promptly executing any documents necessary to effectuate such assignment. Any reasonable, documented out-of-pocket costs and expenses (without markup) incurred by Esperion in connection with the assignment of the Esperion Unbranded Domain Name(s) owned by Esperion to DSE will be reimbursed by DSE to Esperion within thirty (30) days from receipt of an invoice therefor.

8.Confidentiality. The provisions of Section 7.1 (Nondisclosure Obligation) of the LCA are hereby incorporated into this 2nd Amendment by reference and shall apply to this 2nd Amendment, mutatis mutandis.

9.Assignment. This 2nd Amendment may not be assigned, nor may any right or obligation hereunder be assigned, by either Party without the prior written consent of the other Party, except that either Party may assign this 2nd Amendment, and its rights and obligations hereunder, without the other Party’s prior written consent together with an assignment of the LCA in accordance with Section 14.2 (Assignment) of the LCA.

10.Miscellaneous. The provisions of Sections 14.3 (Governing Law), 14.4 (Jurisdiction),
14.5 (Entire Agreement; Amendment), 14.11 (Notices) and 14.17 (Counterparts) of the LCA are hereby incorporated into this 2nd Amendment by reference and shall apply to this 2nd Amendment, mutatis mutandis.

[THE REMAINDER OF THIS PAGE HAS BEEN LEFT INTENTIONALLY BLANK]
 

IN WITNESS WHEREOF, the Parties have caused this 2nd Amendment to be duly executed by their respective duly authorized officers as of the 2nd Amendment Effective Date.

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	ESPERION THERAPEUTICS, INC.		DAIICHI SANKYO EUROPE GMBH
				
	By:	/s/ Tim M. Mayleben		By:	/s/ Dr. Jan Van Ruymbeke
	Name:	Tim M. Mayleben		Name:	Dr. Jan Van Ruymbeke
	Title:	President and CEO		Title:	Managing Director / CEO
					
					
				By:	/s/  Martin Hesse
				Name:	Martin Hesse
				Title:	Managing Director / CFO

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Annex 1: Bempe Domain(s)
															
	Local Countries	Domain extension	Branded Domain Name(s)	Domain owner
	EUROPE REGION	.eu	nilemdo.eu	nustendi.eu	DSE
	Andorra	.ad	—	—	—
	Austria	.at	nilemdo.at	nustendi.at	Esperion
	Belgium	.be	nilemdo.be	nustendi.be	Esperion
	Bulgaria	.bg	nilemdo.bg	nustendi.bg	DSE
	Croatia	.hr	nilemdo.hr	nustendi.hr	DSE
	Cyprus	com.cy	nilemdo.hr	nustendi.hr	—
	.cy	—	—	—
	Czech Republic	.cz	nilemdo.cz	nustendi.cz	Esperion
	Denmark	.dk	nilemdo.dk	nustendi.dk	Esperion
	Estonia	.com.ee	nilemdo.com.ee	nustendi.com.ee	DSE
	.ee	nilemdo.ee	nustendi.ee	DSE
	Finland	.fi	nilemdo.fi	nustendi.fi	DSE
	France	.fr	nilemdo.fr	nustendi.fr	Esperion
	Germany	.de	nilemdo.de	nustendi.de	DSE
	Greece	.gr	nilemdo.gr	nustendi.gr	DSE
	Hungary	.hu	—	—	—
	Iceland	.is	nilemdo.is	nustendi.is	DSE
	Ireland	.ie	nilemdo.ie	nustendi.ie	DSE
	Italy	.it	nilemdo.it	nustendi.it	Esperion
	Latvia	.lv	nilemdo.lv	nustendi.lv	DSE
	Liechtenstein	.li	nilemdo.li	nustendi.li	DSE
	Lithuania	.lt	nilemdo.lt	nustendi.lt	DSE
	Luxembourg	.lu	nilemdo.lu	nustendi.lu	DSE
	Malta	.mt	nilemdo.mt	nustendi.mt	DSE
	Monaco	.mc	—	—	—
	Netherlands	.nl	nilemdo.nl	nustendi.nl	Esperion
	Norway	.no	—	—	—
	Poland	.pl	nilemdo.pl	nustendi.pl	Esperion
	Portugal	.pt	nilemdo.pt	nustendi.pt	DSE
	Romania	.ro	nilemdo.ro	nustendi.ro	DSE
	San Marino	.sm	nilemdo.sm	nustendi.sm	DSE
	Slovenia	.si	nilemdo.si	nustendi.si	DSE
	Slovakia	.sk	nilemdo.sk	nustendi.sk	DSE
	Spain	.es	nilemdo.es	nustendi.es	DSE
	Sweden	.se	nilemdo.se	nustendi.se	DSE
	Switzerland	.ch	nilemdo.ch	nustendi.ch	Esperion
	UK	.co.uk	nilemdo.co.uk	nustendi.co.uk	Esperion
	.uk	nilemdo.uk	nustendi.uk	Esperion
	Turkey	.com.tr	—	—	—
	.tr	—	—	—

 															
	Local Countries	Domain extension	Branded Domain Name(s)	Domain owner
	EUROPE REGION	.eu	nilemdo-nustendi.eu	DSE
	Andorra	.ad	—	—
	Austria	.at	nilemdo-nustendi.at	Esperion
	Belgium	.be	nilemdo-nustendi.be	Esperion
	Bulgaria	.bg	nilemdo-nustendi.bg	DSE
	Croatia	.hr	nilemdo-nustendi.hr	DSE
	Cyprus	com.cy	nilemdo-nustendi.hr	—
	.cy	—	—
	Czech Republic	.cz	nilemdo-nustendi.cz	Esperion
	Denmark	.dk	nilemdo-nustendi.dk	Esperion
	Estonia	.com.ee	nilemdo-nustendi.com.ee	DSE
	.ee	nilemdo-nustendi.ee	DSE
	Finland	.fi	nilemdo-nustendi.fi	DSE
	France	.fr	nilemdo-nustendi.fr	Esperion
	Germany	.de	nilemdo-nustendi.de	DSE
	Greece	.gr	nilemdo-nustendi.gr	DSE
	Hungary	.hu	—	—
	Iceland	.is	nilemdo-nustendi.is	DSE
	Ireland	.ie	nilemdo-nustendi.ie	DSE
	Italy	.it	nilemdo-nustendi.it	Esperion
	Latvia	.lv	nilemdo-nustendi.lv	DSE
	Liechtenstein	.li	nilemdo-nustendi.li	DSE
	Lithuania	.lt	nilemdo-nustendi.lt	DSE
	Luxembourg	.lu	nilemdo-nustendi.lu	DSE
	Malta	.mt	nilemdo-nustendi.mt	DSE
	Monaco	.mc	—	—
	Netherlands	.nl	nilemdo-nustendi.nl	Esperion
	Norway	.no	—	—
	Poland	.pl	nilemdo-nustendi.pl	Esperion
	Portugal	.pt	nilemdo-nustendi.pt	DSE
	Romania	.ro	nilemdo-nustendi.ro	DSE
	San Marino	.sm	nilemdo-nustendi.sm	DSE
	Slovenia	.si	nilemdo-nustendi.si	DSE
	Slovakia	.sk	nilemdo-nustendi.sk	DSE
	Spain	.es	nilemdo-nustendi.es	DSE
	Sweden	.se	nilemdo-nustendi.se	DSE
	Switzerland	.ch	nilemdo-nustendi.ch	Esperion
	UK	.co.uk	nilemdo-nustendi.co.uk	Esperion
	.uk	nilemdo-nustendi.uk	Esperion
	Turkey	.com.tr	—	—
	.tr	—	—

5

												
	Local Countries	Domain extension	Unbranded Domain Name(s)	Domain owner
	EUROPE REGION	.eu	myldltreatment.eu
	DSE
	Global	.com	myldltreatment.com	DSE
	UK	.co.uk	myldltreatment.co.uk	DSE
	EUROPE REGION	.eu	lower-ldl.eu	DSE
	EUROPE REGION	.eu	lowerldl.eu	DSE

6

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00327-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00327-of-00352.parquet"}]]