Document:

EX-4.2

 Exhibit 4.2 

EXECUTION VERSION 

DH EUROPE FINANCE S.A., 

as Issuer 
 DANAHER
CORPORATION, 
 as Guarantor 

AND 
 THE BANK OF NEW
YORK MELLON TRUST COMPANY, N.A., 
 as Trustee 
  

 
 SECOND
SUPPLEMENTAL INDENTURE 
 Floating Rate Senior Notes Due 2022 

1.200% Senior Notes Due 2027 

Dated as of June 30, 2017 
  

 
  

 THIS SECOND SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated
as of June 30, 2017, is among DH EUROPE FINANCE S.A., a public limited liability company, société anonyme, duly organized and existing under the laws of Luxembourg (the “Company”), having its registered
office at 1B Heienhaff, L-1736 Senningerberg, Grand Duchy of Luxembourg and registered with the Luxembourg Trade and Companies Register under number B197470, DANAHER CORPORATION, a corporation duly organized and existing under the laws of the State
of Delaware (the “Guarantor”) and the indirect parent company of the Company, having its principal office at 2200 Pennsylvania Avenue, N.W., Suite 800W, Washington, D.C. 20037-1701, and THE BANK OF NEW YORK MELLON TRUST
COMPANY, N.A., a national banking association duly organized and existing under the laws of the United States of America, as Trustee (the “Trustee”). 

RECITALS 
 WHEREAS, the
Company and the Guarantor have heretofore executed and delivered to the Trustee an Indenture dated as of July 8, 2015, among the Company, the Guarantor and the Trustee (the “Base Indenture,” and together with this Supplemental
Indenture, the “Indenture”), providing for the issuance from time to time of series of the Company’s Securities and Guarantees of such Securities by the Guarantor; 

WHEREAS, Section 901(g) of the Base Indenture provides for the Company, the Guarantor and the Trustee to enter into an indenture
supplemental to the Base Indenture to establish the form or terms of Securities of any series as permitted by Section 201 and Section 301 of the Base Indenture; 

WHEREAS, pursuant to Section 301 of the Base Indenture, the Company wishes to provide for the issuance of two (2) new series
of Securities to be known as its: (a) Floating Rate Senior Notes due 2022 (the “Floating Rate Notes”) and (b) 1.200% Senior Notes due 2027 (the “2027 Notes,” and together with the Floating Rate Notes, the
“Notes”). The forms of the Notes of each such series and the terms, provisions and conditions thereof shall be as set forth in this Supplemental Indenture; 

WHEREAS, the Guarantor desires to Guarantee each series of Notes on the terms set forth in Article 14 of the Base Indenture; and 

WHEREAS, the Company and the Guarantor have requested that the Trustee execute and deliver this Supplemental Indenture, and all requirements
necessary to make this Supplemental Indenture a valid and binding instrument enforceable in accordance with its terms, to make each series of Notes, when executed and delivered by the Company and authenticated by the Trustee, the valid, binding and
enforceable obligations of the Company, and to make the Guarantees of each series of Notes, when such series of Notes have been executed and delivered by the Company and authenticated by the Trustee, and when the notations of Guarantee to be
attached to each Note are executed and delivered by the Guarantor, the valid, binding and enforceable obligations of the Guarantor, in each case, have been done and performed, and the execution and delivery of this Supplemental Indenture has been
duly authorized in all respects; 

  
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 NOW, THEREFORE, in consideration of the covenants and agreements set forth herein and for other
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 

ARTICLE I 
 DEFINITIONS 

Section 1.01 Relation to Base Indenture. This Supplemental Indenture constitutes an integral part of the Base
Indenture. 
 Section 1.02 Definition of Terms. For all purposes of this Supplemental Indenture:

 (a) Capitalized terms used herein without definition shall have the meanings set forth in the Base Indenture; 

(b) a term defined anywhere in this Supplemental Indenture has the same meaning throughout and, to the extent any such term conflicts
with a corresponding term defined in the Base Indenture or is otherwise set forth both in this Supplemental Indenture and in the Base Indenture, such term as defined in this Supplemental Indenture shall supersede the corresponding term defined in
the Base Indenture with respect to the Notes; 
 (c) the singular includes the plural and vice versa; 

(d) headings are for convenience of reference only and do not affect interpretation; and 

(e) the following terms have the meanings given to them in this Section 1.02(e): 

“2027 Notes Interest Payment Date” shall have the meaning set forth in Section 2.06(b). 

“2027 Notes Maturity Date” shall have the meaning set forth in Section 2.02. 

“2027 Notes Paying Agent” shall have the meaning set forth in Section 2.11. 

“2027 Notes Record Date” means the fifteenth calendar day, whether or not a Business Day, immediately preceding the
related 2027 Notes Interest Payment Date, which constitutes a Regular Record Date for purposes of the Base Indenture. 

“Attributable Debt” in respect of a Sale and Leaseback Transaction, means, as of any particular time, the present value (discounted
at the rate of interest implicit in the lease involved in such Sale and Leaseback Transaction, as determined in good faith by the Guarantor) of the obligation of the lessee thereunder for rental payments (excluding, however, any amounts required to
be paid by such lessee, whether or not designated as rent or additional rent, on account of maintenance and repairs, insurance, taxes, assessments, water rates or similar charges or any amounts required to be paid by such lessee thereunder
contingent upon the amount of sales, maintenance and repairs, insurance, taxes, assessments, water rates or similar charges) during the remaining term of such lease (including any period for which such lease has been extended or may, at the option
of the lessor, be extended). 

  
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 “Base Rate” shall have the meaning set forth in Section 2.05(a). 

“Business Day” means any day other than a Saturday or Sunday, which is (1) not a day on which banking
institutions in The City of New York or London are authorized or required by law, regulation or executive order to close and (2) a TARGET2 Business Day. 

“Change of Control” means the occurrence of any of the following: (1) the consummation of any transaction
(including, without limitation, any merger or consolidation) the result of which is that any “person” (as that term is defined in Section 13(d)(3) of the Exchange Act) (other than (a) the Guarantor or one of its Subsidiaries,
(b) any employee benefit plan of such Person or its Subsidiaries, and any Person acting in its capacity as trustee, agent or other fiduciary or administrator of any such plan and (c) Steven M. Rales and Mitchell P. Rales) becomes the
“beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the Guarantor’s Voting Stock or other Voting Stock into which the Guarantor’s Voting Stock is
reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; (2) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or more
series of related transactions, of all or substantially all of the Guarantor’s assets and the assets of the Guarantor’s Subsidiaries, taken as a whole, to any “person” (as that term is defined in Section 13(d)(3) of the
Exchange Act) (other than the Guarantor or one of its Subsidiaries); or (3) the Guarantor ceases to own, directly or indirectly, 100% of the equity interests of the Company, other than as a result of the merger or consolidation of the Company
with and into the Guarantor. Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control if (1) the Guarantor becomes a direct or indirect wholly-owned subsidiary of a holding company and (2)(A) the
direct or indirect holders of the Voting Stock of such holding company immediately following that transaction are substantially the same as the holders of the Guarantor’s Voting Stock immediately prior to that transaction or
(B) immediately following that transaction no Person (other than a holding company satisfying the requirements of this sentence) is the beneficial owner, directly or indirectly, of more than 50% of the Voting Stock of such holding company.

 “Change of Control Offer” shall have the meaning set forth in Section 3.03. 

“Change of Control Payment” shall have the meaning set forth in Section 3.03. 

“Change of Control Payment Date” shall have the meaning set forth in Section 3.03. 

“Change of Control Triggering Event,” with respect to any series of Notes, means the occurrence of both a Change of
Control and a Rating Event with respect to such series. No Change of Control Triggering Event will be deemed to have occurred in connection with any particular Change of Control unless and until such Change of Control has actually been
consummated. 
 “Clearstream” means Clearstream Banking, S.A. 

  
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 “Common Depositary” means any Person acting as common depositary for
Euroclear and Clearstream or its successor as appointed as such by the Depositary, which shall initially be The Bank of New York Mellon, London Branch. 

“Comparable Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion
of an independent investment bank selected by the Company, a German government bond whose maturity is closest to March 30, 2027, or if such independent investment bank in its discretion determines that such similar bond is not in issue, such
other German government bond as such independent investment bank may, with the advice of three brokers of, and/or market makers in, German government bonds selected by the Company, determine to be appropriate for determining the Comparable
Government Bond Rate. 
 “Comparable Government Bond Rate” means, with respect to any Redemption Date, the
price, expressed as a percentage (rounded to three decimal places, with 0.0005 being rounded upwards), at which the gross redemption yield on the 2027 Notes to be redeemed, if they were to be purchased at such price on the third Business Day prior
to the date fixed for redemption, would be equal to the gross redemption yield on such Business Day of the Comparable Government Bond on the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on
such Business Day as determined by an independent investment bank selected by the Company. 
 “Consolidated
Assets” means the aggregate of all assets of the Guarantor and its Subsidiaries (including the value of all existing Sale and Leaseback Transactions and any assets resulting from the capitalization of other long-term lease obligations in
accordance with GAAP), appearing on the most recent available consolidated balance sheet of the Guarantor and its Subsidiaries at their net book values, after deducting related depreciation, amortization and other valuation reserves, all prepared in
accordance with GAAP. 
 “Consolidated Current Liabilities” means the aggregate of the current liabilities of
the Guarantor and its Subsidiaries appearing on the most recent available consolidated balance sheet of the Guarantor and its Subsidiaries, all in accordance with GAAP (excluding current maturities of long-term debt and obligations under capital
leases). In no event shall Consolidated Current Liabilities include any obligation of the Guarantor and its Subsidiaries issued under a revolving credit or similar agreement if the obligation issued under such agreement matures by its terms within
twelve months from the date thereof but by the terms of such agreement such obligation may be renewed or extended or the amount thereof reborrowed or refunded at the Guarantor’s option or the option of any of its Subsidiaries such that such
obligation would mature on a date that is more than twelve months from the date of determination. 
 “Consolidated Net
Assets” means Consolidated Assets after deduction of Consolidated Current Liabilities. 
 “Depositary”
means each of Clearstream and Euroclear. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

  
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 “EURIBOR Interest Determination Date” shall have the meaning set forth in
Section 2.05(a) 
 “Euroclear” means Euroclear Bank S.A./N.V. 

“Euro-Zone” means, at any time, the region comprised of the countries (if any) then participating in the European
Economic and Monetary Union (or any successor union) pursuant to the Treaty on European Union of February 1992 (or any successor treaty), as it may be amended from time to time. 

“Floating Rate Notes Interest Payment Date” shall have the meaning set forth in Section 2.05(a). 

“Floating Rate Notes Maturity Date” shall have the meaning set forth in Section 2.02. 

“Floating Rate Notes Paying Agent” shall have the meaning set forth in Section 2.11. 

“Floating Rate Notes Record Date” means the fifteenth calendar day, whether or not a Business Day, immediately
preceding the related Floating Rate Interest Payment Date, which constitutes a Regular Record Date for purposes of the Base Indenture. 

“Funded Debt” means all indebtedness for money borrowed having a maturity of more than twelve months from the date of
the most recent consolidated balance sheet of the Guarantor and its Subsidiaries or renewable and extendable beyond twelve months at the option of the borrower and all obligations in respect of lease rentals which under GAAP would be shown on the
Guarantor’s consolidated balance sheet as a liability item other than a current liability; provided, however, that Funded Debt shall not include any of the foregoing to the extent that such indebtedness
or obligations are not required by GAAP to be shown on the Guarantor’s balance sheet; provided further, however, that if any operating lease would be recharacterized as a capital lease due to changes in
the accounting treatment of such operating leases under GAAP since the date of the Indenture, then solely with respect to the accounting treatment of any such lease, GAAP shall be interpreted as it was in effect on the date of the Indenture. 

 “Global Note” shall have the meaning set forth in Section 2.04. 

“Interest Payment Date” means the Floating Rate Notes Interest Payment Date or the 2027 Notes Interest Payment Date,
as applicable. 
 “Interest Reset Date” shall have the meaning set forth in Section 2.05(a). 

“Investment Grade Rating” means a rating equal to or higher than Baa3 (or the equivalent) by Moody’s and BBB- (or
the equivalent) by S&P; and, the equivalent investment grade credit rating from any additional rating agency or rating agencies selected by the Guarantor. 

“Issue Date” means June 30, 2017. 

  
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 “Market Exchange Rate” means the noon buying rate in The City of New York
for cable transfers of euro as certified for customs purposes (or, if not so certified, as otherwise determined) by the Federal Reserve Bank of New York. 

“Maturity Date” means the Floating Rate Notes Maturity Date or the 2027 Notes Maturity Date, as applicable.

 “Moody’s” means Moody’s Investors Service Inc., and any successor to its rating agency business.

 “Paying Agent” shall have the meaning set forth in Section 2.11. 

“Paying and Calculation Agent” means The Bank of New York Mellon, London Branch, or its successor appointed as such by
the Company. 
 “Paying and Calculation Agency Agreement” means the Paying and Calculation Agency Agreement,
dated as of June 30, 2017, among the Company, the Guarantor, the Trustee and the Paying and Calculation Agent, as it may be amended from time to time. 

“Principal Property” means any manufacturing plant, warehouse, office building or single parcel of real property
(including fixtures but excluding leases and other contract rights which might otherwise be deemed real property) owned by the Guarantor or any of its Subsidiaries and located in the United States as of the date of determination,
provided each such plant, warehouse, office building or parcel of real property has a gross book value (without deduction for any depreciation reserves) at the date as of which the determination is being made of in excess of two
percent of the Consolidated Net Assets of the Guarantor and its Subsidiaries, other than any such plant, warehouse, office building or parcel of real property or portion thereof which, in the opinion of the board of directors of the Guarantor
(evidenced by a Board Resolution of the Guarantor delivered to the Trustee), is not of material importance to the business conducted by the Guarantor and its Subsidiaries taken as a whole. 

“Rating Agency” means (1) each of Moody’s and S&P; and (2) if either of Moody’s or S&P
ceases to rate the applicable series of Notes or fails to make a rating of such series of Notes publicly available for reasons outside of the Company’s or the Guarantor’s control, a “nationally recognized statistical rating
organization” within the meaning of Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act selected by the Guarantor (as certified by a Board Resolution of the Guarantor) as a replacement agency for Moody’s or S&P, or both of them, as the
case may be. 
 “Rating Event” means the rating on the applicable series of Notes is lowered by
each of the Rating Agencies and such series of Notes is rated below an Investment Grade Rating by each of the Rating Agencies on any day within the 60-day period (which 60-day period will be extended so long as the rating of such series of Notes is
under publicly announced consideration for a possible downgrade by any of the Rating Agencies) after the earlier of (1) the occurrence of a Change of Control and (2) public notice of the occurrence of a Change of Control or the
Guarantor’s intention to effect a Change of Control; provided, however, that a Rating Event otherwise arising by virtue of a particular reduction in rating will not be deemed to have occurred in respect of a particular Change of Control
(and thus will not be deemed a Rating Event for  

  
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purposes of the definition of Change of Control Triggering Event) if the Rating Agencies making the reduction in rating to which this definition would otherwise apply do not announce or publicly
confirm or inform the Trustee in writing at the Company’s or its request that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result of, or in respect of, the applicable Change of
Control (whether or not the applicable Change of Control has occurred at the time of the Rating Event). 
 “Redemption
Date” means, with respect to any redemption of any series of Notes, the date fixed for such redemption pursuant to the Indenture and such series of Notes. 

“Remaining Scheduled Payments” means, with respect to the 2027 Notes to be redeemed, the remaining scheduled payments
of the principal thereof and interest thereon that would be due after the related Redemption Date (assuming that such 2027 Notes matured on March 30, 2027) but for such redemption; provided, however,
that, if such Redemption Date is not an Interest Payment Date with respect to the 2027 Notes, the amount of the next succeeding scheduled interest payment thereon will be deemed to be reduced by the amount of interest accrued thereon to such
Redemption Date. 
 “Sale and Leaseback Transaction” shall have the meaning set forth in Section 6.02. 

“S&P” means S&P Global Ratings, a division of S&P Global Inc., and any successor to its rating agency business.

 “Secured Debt” means indebtedness for borrowed money and any Funded Debt which, in each case, is secured by a security
interest in (1) any Principal Property, or (2) any shares of capital stock or Indebtedness of any Subsidiary that owns a Principal Property. 

“TARGET2 System” means the Trans-European Automated Real-Time Gross Settlement Express Transfer System and any
successor thereto. 
 “TARGET2 Business Day” means any day on which the TARGET2 System is open for business. 

“Voting Stock” means, with respect to any specified Person as of any date, the capital stock of such Person that is at
the time entitled to vote generally in the election of the Board of Directors or similar governing body of such Person. 
 The
terms “2027 Notes,” “Base Indenture,” “Company,” “Floating Rate Notes,” “Guarantor,” “Indenture,” “Notes” and
“Trustee” shall have the respective meanings set forth in the recitals to this Supplemental Indenture and the paragraph preceding such recitals. 

ARTICLE II 
 GENERAL TERMS AND
CONDITIONS OF THE NOTES 
 Section 2.01 Designation and Principal Amount. Each series of Notes may be issued from
time to time upon written order of the Company for the authentication and delivery of such series of Notes pursuant to Section 303 of the Base Indenture. There are hereby authorized: 

  
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 (a) a series of Securities designated as the Floating Rate Senior Notes due 2022, limited
in initial aggregate principal amount to €250,000,000 (except upon registration of transfer of, or in exchange for, or in lieu of, other Securities pursuant to Sections 304, 305, 306, 906 or 1107 of the Base Indenture); and 

(b) a series of Securities designated as the 1.200% Senior Notes due 2027, limited in initial aggregate principal amount to
€600,000,000 (except upon registration of transfer of, or in exchange for, or in lieu of, other Securities pursuant to Sections 304, 305, 306, 906 or 1107 of the Base Indenture). 

The Company may create and issue additional Notes of any series having the same terms and conditions as such series of Notes in all respects (or in all
respects except for the Issue Date, issue price and, to the extent applicable, the payment of interest accruing prior to the Issue Date of such additional Notes or the first payment of interest following the Issue Date), so that such additional
Notes of such series will be consolidated and form a single series with the initial Notes of such series. 
 Section 2.02
Maturity. (a) The date upon which the Floating Rate Notes shall become due and payable at final maturity, together with any accrued and unpaid interest, is June 30, 2022 (the “Floating Rate Notes Maturity
Date”) and (b) the date upon which the 2027 Notes shall become due and payable at final maturity, together with any accrued and unpaid interest, is June 30, 2027 (the “2027 Notes Maturity Date”).

 Section 2.03 Form, Payment and Appointment. Except as provided in Section 2.04, each series of Notes
shall be issued in fully registered, certificated form. Principal of and interest on each series of Notes will be payable, the transfer of such series of Notes will be registrable, and such series of Notes will be exchangeable for such series of
Notes of a like aggregate principal amount, at the office or agency of the Company maintained for such purpose located at One Canada Square, London E14 5AL, United Kingdom, which shall initially be the corporate trust office of the Paying and
Calculation Agent; provided, however, that payment of interest may be made at the option of the Company by check mailed to the Person entitled thereto at such address as shall appear in the Security register or by wire transfer to an
account appropriately designated by the Person entitled to payment; provided, that the Paying and Calculation Agent shall have received written notice of such account designation at least five (5) Business Days prior to the date of such
payment (subject to surrender of the relevant Note in the case of a payment of interest on a Redemption Date or the Maturity Date). 

No service charge shall be made for any registration of transfer or exchange of any series of Notes, but the Company may require payment from
the applicable Holder of a sum sufficient to cover any tax or other governmental charge that may be imposed in connection therewith. 
 The
Notes shall be issuable in denominations of €100,000 and integral multiples of €1,000 in excess thereof. 
 The specified currency
of the Notes shall be euro. Initial Holders of Notes of a series will be required to pay for such Notes in euro, and all payments of interest and principal, including payments made upon any redemption or repurchase of such Notes, will be payable in
euro 

  
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(except as otherwise provided in this Section 2.03) in immediately available funds at the corporate trust office of the Paying and Calculation Agent or such other place designated by the
Company with written notification to the Trustee. If the euro is unavailable to the Company or, in the case of the Guarantees, the Guarantor due to the imposition of exchange controls or other circumstances beyond the Company’s or the
Guarantor’s control or if the euro is no longer being used by the then-member states of the European Economic and Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or
within the international banking community, then all payments in respect of the Notes of each series shall be made in U.S. dollars until the euro is again available to the Company or, in the case of the Guarantees, the Guarantor or so used. In such
circumstances, the amount payable on any date in euro will be converted into U.S. dollars on the basis of the most recently available Market Exchange Rate for the euro. Any payment in respect of the Notes of a series so made in U.S. dollars will not
constitute an Event of Default under such series of Notes or the Indenture. Neither the Trustee nor the Paying and Calculation Agent for the Notes shall have any responsibility for any calculation or conversion in connection with the foregoing. 

Section 2.04 Global Notes. The Notes of each series shall be issued initially in the form of a permanent Global
Security in registered form (each, a “Global Note”), deposited with, or on behalf of, Euroclear and Clearstream, and registered in the name of the nominee of the Common Depositary or its nominee for the accounts of
Euroclear and Clearstream. Unless and until a Global Note is exchanged for Notes of such series in certificated form, such Global Note may be transferred, in whole but not in part. 

All payments due in respect of any series of Notes while such Notes are in the form of a Global Note, including the redemption price due in
respect of the redemption of any such series, shall be made to the Paying and Calculation Agent, which in turn shall make payment with respect to the applicable series of Notes to the Common Depositary for the account of Euroclear and Clearstream,
or in each case to their respective successors selected or approved by the Company or to the nominee of such successor. 

Section 2.05 Interest on the Floating Rate Notes. (a) The Floating Rate Notes shall bear interest at a rate
equivalent to the 3-month EURIBOR (the “Base Rate”) plus 0.300% per year, as calculated by the Paying and Calculation Agent; provided, however, that the minimum interest rate shall be zero. The Floating
Rate Notes will bear interest from the Issue Date or from the immediately preceding Floating Rate Notes Interest Payment Date to which interest has been paid or duly provided for. Interest on the Floating Rate Notes shall be payable quarterly in
arrears on March 31, June 30, September 30 and December 31 of each year (each, a “Floating Rate Notes Interest Payment Date”), commencing on September 30, 2017; provided, that,
if any Floating Rate Notes Interest Payment Date would be a day that is not a Business Day, such Floating Rate Notes Interest Payment Date shall be the next succeeding day that is a Business Day (and no additional interest will accrue or otherwise
accumulate on the amount payable for the period from and after such Floating Rate Notes Interest Payment Date); except that if such next succeeding Business Day falls in the next succeeding calendar month, such Floating Rate Notes Interest Payment
Date shall be the immediately preceding Business Day. The interest rate on the Floating Rate Notes will be reset quarterly on March 31, June 30, September 30 and December 31 of each year (each, an “Interest
Reset Date”), commencing on September 30, 2017; provided, that, if any Interest Reset Date would be a day that is not a Business Day, such  

  
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Interest Reset Date shall be the next succeeding day that is a Business Day, except that if such next succeeding Business Day falls in the next succeeding calendar month, such Interest Reset
Date shall be the immediately preceding Business Day. The initial Base Rate for the Floating Rate Notes in effect from the Issue Date to, but excluding, the first Interest Reset Date will be the 3-month EURIBOR in effect on June 28, 2017. The
interest rate on the Floating Rate Notes will be determined on the second TARGET2 Business Day preceding the applicable Interest Reset Date (a “EURIBOR Interest Determination Date”). Interest on a Floating Rate Notes Interest
Payment Date shall be paid to the Persons in whose names the Floating Rate Notes are registered on the Security Register at the close of business on the Floating Rate Notes Record Date, except as provided in Section 2.07. Interest on the
Floating Rate Notes will be computed on the basis of a 360-day year and the actual number of days in the period for which interest is being calculated. 

(b) The Base Rate that takes effect on any Interest Reset Date shall equal the interest rate for deposits in euro designated as
“EURIBOR” and sponsored jointly by the European Banking Federation and ACI — the Financial Market Association (or any company established by the joint sponsors for purposes of compiling and publishing that rate) on each EURIBOR
Interest Determination Date, and will be determined by the Paying and Calculation Agent in accordance with the following provisions: 

(i) EURIBOR will be the offered rate for deposits in euro having a maturity of three months, as that rate appears on
Reuters Page EURIBOR01 as of 11:00 a.m., Brussels time, on the relevant EURIBOR Interest Determination Date. 
 (ii)
If the rate described in clause (i) above does not appear on Reuters Page EURIBOR01, EURIBOR will be determined on the basis of the rates, at approximately 11:00 a.m., Brussels time, on the relevant EURIBOR Interest Determination Date, at which
deposits of the following kind are offered to prime banks in the Euro-Zone interbank market by the principal Euro-Zone office of each of four major banks in that market selected by the Company: euro deposits having a maturity of three months
beginning on such Interest Reset Date and in a principal amount of not less than €1,000,000 that is representative for a single transaction in such market at such time. The Paying and Calculation Agent will request the principal Euro-Zone
office of each of these banks to provide a quotation in writing of its rate. If at least two quotations are provided in writing, EURIBOR for such EURIBOR Interest Determination Date will be the arithmetic mean (rounded upwards) calculated by the
Paying and Calculation Agent of such quotations. The Company will ensure that the Paying and Calculation Agent is provided with appropriate contact details of the relevant personnel at each of the reference banks that the Paying and Calculation
Agent will be requested to contact to provide such quotation of its rates. 
 (iii) If fewer than two quotations are
provided as described in clause (ii) above, EURIBOR for the relevant EURIBOR Interest Determination Date will be the arithmetic mean of the rates for loans of the following kind to leading Euro-Zone banks quoted in writing, at approximately
11:00 a.m., Brussels time, on such EURIBOR Interest Determination Date, by three major banks in the Euro-Zone selected by the Company: loans of euro having a maturity of three months beginning on such Interest Reset Date and in a principal amount of
not less than €1,000,000 that is representative for a single transaction in such market at such time. 

  
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 (iv) If fewer than three banks selected by the Company are quoting as
described in clause (iii) above, EURIBOR shall be the EURIBOR in effect on such EURIBOR Interest Determination Date (or, in the case of the first Interest Reset Date, the initial Base Rate). 

(c) Upon request of the Holder to the Paying and Calculation Agent, the Paying and Calculation Agent will provide the interest rate
then in effect on the Floating Rate Notes and, if determined, the interest rate that will become effective on the next Interest Reset Date. 

(d) All percentages resulting from any calculation with respect to the Floating Rate Notes will be rounded upward or downward, as
appropriate, to the next higher or lower one hundred-thousandth of a percentage point (e.g., 9.876541% (or .09876541) being rounded down to 9.87654% (or .0987654) and 9.876545% (or .09876545) being rounded up to 9.87655% (or .0987655)). All amounts
used in or resulting from any calculation with respect to the Floating Rate Notes will be rounded upward or downward, as appropriate, to the nearest cent, in the case of euro amounts or U.S. dollars, or to the nearest corresponding hundredth of a
unit, in the case of a currency other than euro amounts or U.S. dollars, with one-half cent or one-half of a corresponding hundredth of a unit or more being rounded upward. 

Section 2.06 Interest on the 2027 Notes. (a) Interest payable on any Interest Payment Date, the
Maturity Date or, if applicable, a Redemption Date, with respect to the 2027 Notes shall be the amount of interest accrued from, and including, the immediately preceding Interest Payment Date in respect of which interest has been paid or duly
provided for (or from and including the Issue Date, if no interest has previously been paid or duly provided for with respect to the 2027 Notes) to, but excluding, such Interest Payment Date, Maturity Date or, if applicable, Redemption Date, as the
case may be. Interest on the 2027 Notes will be computed on the basis of the actual number of days in the period for which interest is being calculated and the actual number of days from and including the last date on which interest was paid on the
2027 Notes (or the Issue Date if no interest has been paid on the 2027 Notes), to but excluding the next scheduled Interest Payment Date, Maturity Date or Redemption Date, as applicable. This payment convention is referred to as ACTUAL/ACTUAL (ICMA)
as defined in the rulebook of the International Capital Markets Association. 
 (b) The 2027 Notes will bear interest at the
rate of 1.200% per year. Interest on the 2027 Notes shall be payable annually in arrears on June 30 of each year (each, a “2027 Notes Interest Payment Date”), commencing June 30, 2018, to the Persons in whose names
the 2027 Notes are registered at the close of business on the 2027 Notes Record Date for such 2027 Notes Interest Payment Date, except as provided in Section 2.07. 

Section 2.07 In the event that any Interest Payment Date with respect to the 2027 Notes or the Maturity Date or a Redemption Date
for any series of Notes falls on a day that is not a Business Day, then the related payments of principal, premium, if any, and interest shall be made on the next succeeding day that is a Business Day (and no additional interest will accrue or
otherwise accumulate on the amount payable for the period from and after such Interest Payment  

  
 - 12 - 

 
Date, Maturity Date or Redemption Date, as applicable). Interest due on the Maturity Date or a Redemption Date (in each case, whether or not an Interest Payment Date) of any series of Notes will
be paid to the Person to whom principal of such Notes is payable. 
 Section 2.08 Payments of Additional Amounts.
The provisions of Section 1502 of the Base Indenture shall apply to each series of Notes. Whenever in any series of Notes there is mentioned, in any context, the payment of the principal of or interest or any other amounts on, or in respect
of, such series of Notes, such mention shall be deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof pursuant to the terms hereof and
the Indenture, and express mention of the payment of Additional Amounts in any provision of any series of Notes shall not be construed as excluding the payment of Additional Amounts in those provisions thereof where such express mention is not
made. 
 Section 2.09 No Sinking Fund. The Notes are not entitled to the benefit of any sinking fund.

 Section 2.10 Guarantees. Each series of Notes shall have the benefit of a Guarantee from the Guarantor on
the terms set forth in Article 14 of the Base Indenture. 
 Section 2.11 Security Registrar; Paying and
Calculation Agent. The Security Registrar for each series of Notes shall initially be the Trustee. A copy of the Security Register shall be maintained by the Company at its registered office, in order to comply with Luxembourg law (the
“Duplicate Register”). In case of discrepancy between the Security Register and the Duplicate Register, the Duplicate Register shall prevail for Luxembourg law purposes. 

The paying agent for the 2027 Notes shall initially be the Paying and Calculation Agent (in such capacity, the “2027 Notes
Paying Agent”). With respect to the Floating Rate Notes, the Paying and Calculation Agent shall act as the paying agent (in such capacity, the “Floating Rate Notes Paying Agent” and, together with the 2027 Notes Paying
Agent, each, a “Paying Agent”) and/or the calculation agent in accordance with the terms of the Paying and Calculation Agency Agreement. The Company may change either Paying Agent, the Paying and Calculation Agent and/or the Trustee
without prior notice to any Holder. The Company will give the Trustee prompt written notice of any change in any such appointment. Insofar as any series of Notes provide for any such agent to obtain rates, quotes or other data from a bank, dealer or
other institution for use in making any determination hereunder, such agent may do so from any institution or institutions of the kind contemplated hereby notwithstanding that any one or more of such institutions are Affiliates of any such agent or
Affiliates of the Company. All determinations made by the Paying and Calculation Agent may be made by such agent in its sole discretion and, absent manifest error, shall be conclusive for all purposes and binding on the Holders of the applicable
series of Notes and the Company. 

  
 - 13 - 

 ARTICLE III 

REDEMPTION OF THE NOTES 

Section 3.01 Optional Redemption by Company. (a) Except as set forth in Section 3.02, the Floating Rate
Notes shall not be redeemable prior to the Floating Rate Notes Maturity Date. 
 (b) At any time and from time to time prior to
March 30, 2027, the Company has the right, at its option, to redeem the 2027 Notes, in whole or in part, at a redemption price equal to the greater of: 

(i) 100% of the principal amount of the 2027 Notes to be redeemed, and 

(ii) the sum of the present values of the Remaining Scheduled Payments on the 2027 Notes to be redeemed (not including
any portion of the payments of interest that will be accrued and unpaid to and including the Redemption Date) discounted to the Redemption Date on an annual basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 15 basis
points, plus accrued and unpaid interest, if any, on the principal amount of the 2027 Notes being redeemed to, but excluding, the Redemption Date. 

(c) On or after March 30, 2027, the Company has the right, at its option, to redeem the 2027 Notes, in whole or in part, at any
time and from time to time, at a redemption price equal to 100% of the principal amount of the 2027 Notes to be redeemed, plus accrued and unpaid interest, if any, on the principal amount of the 2027 Notes being redeemed to, but excluding, the
Redemption Date. 
 (d) The Company will cause the notice of any redemption to be mailed (or sent electronically in accordance with
applicable Depositary procedures) to the registered Holders of the applicable 2027 Notes to be redeemed not less than 30 nor more than 60 days prior to the Redemption Date. If the 2027 Notes are only partially redeemed pursuant to this
Section 3.01, such 2027 Notes to be redeemed will be selected by the Trustee in such manner as in its sole discretion it shall deem appropriate and fair, subject to any applicable Depositary procedures. The price for any redemption pursuant to
this Section 3.01 shall be paid prior to 12:00 noon, London time, on the applicable Redemption Date or at such later time as is then permitted by the rules of the Depositary applicable to the 2027 Notes (if then registered as Global Notes);
provided, that the Company shall deposit with the Trustee or the 2027 Notes Paying Agent an amount sufficient to pay the applicable redemption price by 10:00 a.m., London time, on the date such redemption price is to be paid. 

(e) If money sufficient to pay the redemption price of all of the 2027 Notes (or a portion thereof) to be redeemed on the applicable
Redemption Date is deposited with the Trustee or the 2027 Notes Paying Agent on or before such Redemption Date as provided herein, then on and after such Redemption Date, interest will cease to accrue on such 2027 Notes (or such portion thereof)
called for redemption. 

  
 - 14 - 

 Section 3.02 Redemption Upon Changes in Withholding Tax. The provisions of
Section 1501 of the Base Indenture shall apply to each series of Notes. The redemption price for any redemption pursuant to this Section 3.02 shall be paid prior to 12:00 noon, London time, on the applicable Redemption Date or at such
later time as is then permitted by the rules of the Depositary applicable to the Notes (if then registered as Global Notes); provided, that the Company shall deposit with the Trustee or the applicable Paying Agent an amount sufficient to pay such
redemption price by 10:00 a.m., London time, on the date such redemption price is to be paid. If money sufficient to pay such redemption price of each series of Notes to be redeemed on the applicable Redemption Date is deposited with the Trustee or
the applicable Paying Agent on or before such Redemption Date as provided herein, then on and after such Redemption Date, interest will cease to accrue on such Notes called for redemption. 

Section 3.03 Change of Control Triggering Event. (a) If a Change of Control Triggering Event occurs, unless,
with respect to the 2027 Notes, the Company has exercised its right to redeem the 2027 Notes in full as described in Section 3.01, or with respect to any series of Notes, such series of Notes has become redeemable as described in
Section 3.02, Holders of both series of Notes will have the right to require the Company to repurchase all or any part (equal to €100,000 or an integral multiple of €1,000 in excess thereof) of their Notes pursuant to the offer
described below (the “Change of Control Offer”) on the terms set forth in the Notes. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Notes
repurchased plus accrued and unpaid interest, if any, on the Notes repurchased to the date of purchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, or, at the Company’s
option, prior to the date of the consummation of any Change of Control, but after public announcement of the transaction that constitutes or may constitute the Change of Control, the Company will be required to mail a notice to Holders of each
applicable series of Notes, with a copy to the Trustee, describing the transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase such applicable series of Notes on the date
specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required by the Notes and described
in such notice. The notice shall, if mailed prior to the date of the consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Triggering Event occurring on or prior to the Change of Control
Payment Date. The Company must comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of
the Notes as a result of a Change of Control Triggering Event. To the extent that the provisions of any securities laws or regulations conflict with the Change of Control Triggering Event provisions of the Notes, the Company will comply with the
applicable securities laws and regulations and will not be deemed to have breached its obligations under this Section 3.03 or the Change of Control Triggering Event provisions of the Notes by virtue of such conflicts. 

(b) On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(i) accept for payment all Notes of each applicable series, or portions of such Notes, properly tendered pursuant to the
Change of Control Offer; 

  
 - 15 - 

 (ii) deposit with the applicable Paying Agent an amount equal to the
Change of Control Payment in respect of all Notes of each applicable series, or portions of such Notes, properly tendered; and 

(iii) deliver or cause to be delivered to the Trustee the Notes of each applicable series properly accepted together
with an Officers’ Certificate stating the aggregate principal amount of such Notes, or portions of such Notes, being repurchased. 

(c) The applicable Paying Agent will promptly mail to each Holder of Notes of each applicable series properly tendered the Change of
Control Payment for such Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book-entry) to each such Holder a new Note of such series equal in principal amount to any unpurchased portion of any Notes of such
series surrendered; provided that each new Note will be in a principal amount of €100,000 or an integral multiple of €1,000 in excess thereof. The Company will not be required to make an offer to repurchase Notes of any series upon
a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes of each such series
properly tendered and not withdrawn under its offer. In addition, the Company will not repurchase any Notes if there has occurred and is continuing on the Change of Control Payment Date an Event of Default under the Indenture, other than a default
in the payment of the Change of Control Payment upon a Change of Control Triggering Event. 
 ARTICLE IV 

FORM OF NOTES AND GUARANTEES 

Section 4.01 Form of Notes and Guarantees. (a) The Floating Rate Notes and the Trustee’s
Certificate of Authentication to be endorsed thereon are to be substantially in the forms attached as Exhibit A hereto and (b) the 2027 Notes and the Trustee’s Certificate of Authentication to be endorsed thereon are to be
substantially in the forms attached as Exhibit B hereto, in each case with such changes therein as the officers of the Company executing the Notes (by manual or facsimile signature) may approve, such approval to be conclusively evidenced by
his or her execution thereof. The notation of Guarantee to be attached to each Note is to be substantially in the form attached as Exhibit C hereto, with such changes therein as the officer of the Guarantor executing the notation of Guarantee
(by manual or facsimile signature) may approve, such approval to be conclusively evidenced by their execution thereof. 
 ARTICLE V 

ORIGINAL ISSUE OF NOTES 

Section 5.01 Original Issue of Notes. (a) Floating Rate Notes having an initial aggregate principal amount of
€250,000,000 may from time to time, upon execution of this Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall thereupon authenticate and deliver said Floating Rate Notes to
or upon the written order of the Company pursuant to Section 303 of the Base Indenture without any further action by the Company (other than as required by the Base Indenture). 

  
 - 16 - 

 (b) 2027 Notes having an initial aggregate principal amount of €600,000,000 may from
time to time, upon execution of this Supplemental Indenture, be executed by the Company and delivered to the Trustee for authentication, and the Trustee shall thereupon authenticate and deliver said 2027 Notes to or upon the written order of the
Company pursuant to Section 303 of the Base Indenture without any further action by the Company (other than as required by the Base Indenture). 

ARTICLE VI 
 COVENANTS 

Section 6.01 Limitation on Secured Debt. The Guarantor will not, and will not permit any of its Subsidiaries to, create,
assume, or guarantee any Secured Debt without making effective provision for securing the Securities equally and ratably with such Secured Debt. The foregoing restrictions shall not apply, however, to debt secured by (i) purchase money
mortgages created to secure payment for the acquisition or construction of any property including, but not limited to, any indebtedness incurred by the Guarantor or any of its Subsidiaries prior to, at the time of, or within 18 months after the
later of the acquisition, the completion of construction (including any improvements on an existing property) or the commencement of commercial operation of such property, which indebtedness is incurred for the purpose of financing all or any part
of the purchase price of such property or construction or improvements on such property, (ii) mortgages, pledges, liens, security interest or encumbrances (collectively referred to herein as security interests) on property, or any conditional
sales agreement or any title retention with respect to property, existing at the time of acquisition thereof, whether or not assumed by the Guarantor or any of its Subsidiaries, (iii) security interests on property or shares of capital stock or
indebtedness of any entity existing at the time such entity becomes a Subsidiary, (iv) security interests in property or shares of capital stock or indebtedness of an entity existing at the time such entity is merged into or consolidated with
the Guarantor or any of its Subsidiaries or at the time of a sale, lease, or other disposition of the properties of an entity as an entirety or substantially as an entirety to the Guarantor or any of its Subsidiaries, provided that no such security
interests shall extend to any other Principal Property of the Guarantor or such Subsidiary prior to such acquisition or to other Principal Property thereafter acquired other than additions or improvements to the acquired property, (v) security
interests on the Guarantor’s property or property of a Subsidiary in favor of the United States of America or any state thereof, or in favor of any other country, or any department, agency, instrumentality or political subdivision thereof
(including, without limitation, security interests to secure indebtedness of the pollution control or industrial revenue type) in order to permit the Guarantor or any of its Subsidiaries to perform a contract or to secure indebtedness incurred for
the purpose of financing all or any part of the purchase price for the cost of constructing or improving the property subject to such security interests or which is required by law or regulation as a condition to the transaction of any business or
the exercise of any privilege, franchise or license, (vi) security interests on any property or assets of any Subsidiary to secure indebtedness owing by it to the Guarantor or to another Subsidiary of the Guarantor, (vii) liens securing
reimbursement obligations with respect to letters of credit related to trade payables and issued in the ordinary course of business, which 

  
 - 17 - 

 
liens encumber documents and other property relating to such letters of credit and the products and proceeds thereof, (viii) liens encumbering customary initial deposits and margin deposits
and other liens in the ordinary course of business, in each case securing indebtedness under any interest swap obligations and currency agreements and forward contract, option, futures contracts, futures options or similar agreements or arrangements
designed to protect the Guarantor or any of its Subsidiaries from fluctuations in interest rates or currencies, or (ix) any extension, renewal or replacement or successive extensions, renewals or replacements, in whole or in part, of any
security interest referred to in the foregoing clauses (i) to (viii) inclusive. 
 Section 6.02 Limitation on Sale
and Leaseback Transactions. The Guarantor will not, and will not permit any of its Subsidiaries to, enter any lease longer than three years (excluding leases of newly acquired, improved or constructed property) covering any Principal Property of
the Guarantor or any Subsidiary of the Guarantor that is sold to any other person in connection with such lease (a “Sale and Leaseback Transaction”), unless either (a) the Guarantor or such Subsidiary of the Guarantor would be
entitled, without equally and ratably securing the Securities to incur Indebtedness secured by a mortgage on the Principal Property leased pursuant to clauses (i) through (ix) of Section 6.01 hereof, or (b) an amount equal to the
value of the Principal Property so leased is applied to the retirement, within 180 days of the effective date of such arrangement, of indebtedness for borrowed money incurred or assumed by the Guarantor or a Subsidiary of the Guarantor which is
recorded as Funded Debt as shown on the most recent consolidated balance sheet of the Guarantor and which in the case of such Indebtedness of the Company or the Guarantor, is not subordinate and junior in right of payment to the prior payment of the
Securities, as applicable. 
 Section 6.03 Exempted Indebtedness. Notwithstanding Section 6.01 and
Section 6.02, (1) the Guarantor and any one or more of its Subsidiaries may, without securing the Securities, issue, assume, or guarantee Secured Debt or enter into any Sale and Leaseback Transaction which would otherwise be subject to the
restrictions of Section 6.01 and Section 6.02; provided that, after giving effect thereto, the aggregate amount of such Secured Debt then outstanding (not including Secured Debt permitted under the exceptions set forth in
Section 6.01) and the Attributable Debt of Sale and Leaseback Transactions, other than Sale and Leaseback Transactions in accordance with clause (a) or (b) of Section 6.02, at such time does not exceed 15% of Consolidated Net
Assets, and (2) leases between only the Guarantor and a wholly-owned Subsidiary of the Guarantor or only between wholly-owned Subsidiaries of the Guarantor are permitted. 

Section 6.04 Classification. For purposes of determining compliance with Section 6.01 and Section 6.02,
(a) a lien securing an item of Secured Debt need not be permitted solely by reference to one category (or portion thereof) described in Section 6.01 or Section 6.02, but may be permitted in part under any combination thereof and
(b) in the event that a lien securing an item of Secured Debt (or any portion thereof) meets the criteria of one or more of the categories (or portions thereof) described in Section 6.01 or Section 6.02, the Guarantor may, in its sole
discretion, divide, classify or reclassify, or later divide, classify, or reclassify, such lien securing such item of Secured Debt (or any portion thereof) in any manner that complies (based on circumstances existing at the time of such division,
classification or reclassification) with Section 6.01 and Section 6.02. 

  
 - 18 - 

 ARTICLE VII 

MISCELLANEOUS 

Section 7.01 Ratification and Applicability of Indenture. To the extent of any conflict between the
provisions of this Supplemental Indenture and the Base Indenture, the provisions of this Supplemental Indenture shall control. The provisions of Sections 1010, 1011 and 1012 of the Base Indenture shall not apply to the Floating Rate Notes or the
2027 Notes. The provisions of Sections 1302 and 1303 of the Base Indenture shall apply to the Floating Rate Notes and the 2027 Notes (including with respect to Sections 6.01 and 6.02 of this Supplemental Indenture). Except as otherwise provided in
Section 1.02 and this Section 7.01, the Base Indenture is in all respects ratified and confirmed, and this Supplemental Indenture shall be deemed part of the Base Indenture in the manner and to the extent herein and therein provided. 

Section 7.02 Trustee Not Responsible for Recitals. The recitals herein contained are made by the Company and the Guarantor
and not by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no representation as to the validity or sufficiency of this Supplemental Indenture. 

Section 7.03 New York Law to Govern. THIS SUPPLEMENTAL INDENTURE AND EACH NOTE SHALL BE DEEMED TO BE A CONTRACT MADE UNDER
THE LAWS OF THE STATE OF NEW YORK, AND FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE WITH THE LAWS OF SAID STATE. FOR THE AVOIDANCE OF DOUBT, THE APPLICABILITY OF ARTICLES 86 TO 94-8 OF THE LUXEMBOURG LAW DATED AUGUST 10, 1915 ON COMMERCIAL
COMPANIES, AS AMENDED, SHALL BE EXCLUDED. 
 Section 7.04 Separability. In case any one or more of the provisions
contained in this Supplemental Indenture or in any series of the Notes shall for any reason be held to be invalid, illegal or unenforceable in any respect, then, to the extent permitted by law, such invalidity, illegality or unenforceability shall
not affect any other provisions of this Supplemental Indenture or of such series of the Notes, but this Supplemental Indenture and such series of the Notes shall be construed as if such invalid or illegal or unenforceable provision had never been
contained herein or therein. 
 Section 7.05 Counterparts. This Supplemental Indenture may be executed in any number of
counterparts each of which shall be an original, but such counterparts shall together constitute but one and the same instrument. 

  
 - 19 - 

 IN WITNESS WHEREOF the parties hereto have caused this Supplemental Indenture to be duly
executed, as of the day and year first written above. 
  

			
	
	 DH EUROPE FINANCE S.A.
  

	By:	 	 /s/ Frank T. McFaden

	Name:	 	Frank T. McFaden
	Title:	 	Category A Director
	
	DANAHER CORPORATION
		
	By:	 	/s/ Daniel L. Comas
		
	Name:	 	Daniel L. Comas
	Title:	 	Executive Vice President and Chief Financial Officer
	
	 THE BANK OF NEW YORK MELLON TRUST

COMPANY, N.A.,
 as Trustee

		
	By:	 	/s/ Richard Tarnas
	Name:	 	Richard Tarnas
	Title:	 	Vice President

 [Signature Page to Second Supplemental Indenture] 

  
 - 20 - 

 EXHIBIT A 

[IF THIS NOTE IS TO BE A GLOBAL SECURITY, INSERT:] 
 UNLESS THIS
SECURITY IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR BANK, S.A./N.V., AS OPERATOR OF THE EUROCLEAR SYSTEM (“EUROCLEAR”) AND CLEARSTREAM BANKING, S.A. (“CLEARSTREAM” AND, TOGETHER WITH EUROCLEAR,
“EUROCLEAR/CLEARSTREAM”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR IN SUCH OTHER NAME AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE BANK OF NEW YORK MELLON, LONDON BRANCH, AS COMMON DEPOSITARY FOR THE ACCOUNT OF EUROCLEAR/CLEARSTREAM (AND ANY PAYMENT IS MADE TO THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR TO SUCH OTHER
ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR/CLEARSTREAM), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, THE BANK OF NEW YORK
DEPOSITORY (NOMINEES) LIMITED, HAS AN INTEREST HEREIN. 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND
IS REGISTERED IN THE NAME OF THE COMMON DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY
PERSON OTHER THAN SUCH COMMON DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 DH EUROPE
FINANCE S.A. 
 Floating Rate Senior Note due 2022 
  

					
	
No.                  
                          
	  	 	€                                    
        	 
		
		  	 	CUSIP: 23290Y AF3	 
		  	 	Common Code: 163716224	 
		  	 	ISIN: XS1637162246	 

 DH Europe Finance S.A., a public limited liability company (société anonyme) duly
organized and existing under the laws of Luxembourg, having its registered office at 1 B Heienhaff, L-1736 Senningerberg, Grand Duchy of Luxembourg and registered with the Luxembourg Trade and Companies Register under number B 197470 (herein called
the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to
            , or registered assigns, the principal sum set forth in the Schedule of Increases or Decreases in Note attached hereto on June 30, 2022, and to pay interest thereon
from June 30, 2017 or from the immediately preceding Interest 

  
 A-1 

 
Payment Date to which interest has been paid or duly provided for, quarterly in arrears on March 31, June 30, September 30 and December 31 of each year
(each an “Interest Payment Date”), commencing on September 30, 2017, until the principal hereof is paid or made available for payment; provided, that if any Interest Payment Date would be a day that is not
a Business Day, such Interest Payment Date shall be the next succeeding day that is a Business Day (and no additional interest will accrue or otherwise accumulate on the amount payable for the period from and after such Interest Payment Date);
except that if such next succeeding Business Day falls in the next succeeding calendar month, such Interest Payment Date shall be the immediately preceding Business Day. This Note shall bear interest at a rate equivalent to the 3-month
EURIBOR (the “Base Rate”) plus 0.300% per year, as calculated by the Paying and Calculation Agent; provided, however, that the minimum interest rate shall be zero. The interest rate on this Note will
be reset quarterly on March 31, June 30, September 30 and December 31 of each year (each, an “Interest Reset Date”), commencing on September 30, 2017; provided, that, if any
Interest Reset Date would be a day that is not a Business Day, such Interest Reset Date shall be the next succeeding day that is a Business Day, except that if such next succeeding Business Day falls in the next succeeding calendar month, such
Interest Reset Date shall be the immediately preceding Business Day. The initial Base Rate for this Note in effect from the Issue Date to, but excluding, the first Interest Reset Date will be the 3-month EURIBOR in effect on June 28, 2017.

 The interest rate on this Note will be determined on the second TARGET2 Business Day preceding the applicable Interest Reset
Date (a “EURIBOR Interest Determination Date”). 
 The Base Rate that takes effect on any Interest Reset Date shall
equal the interest rate for deposits in euro designated as “EURIBOR” and sponsored jointly by the European Banking Federation and ACI — the Financial Market Association (or any company established by the joint sponsors for purposes of
compiling and publishing that rate) on each EURIBOR Interest Determination Date, and will be determined by the Paying and Calculation Agent in accordance with the following provisions: 

(i) EURIBOR will be the offered rate for deposits in euro having a maturity of three months, as that rate appears on
Reuters Page EURIBOR01 as of 11:00 a.m., Brussels time, on the relevant EURIBOR Interest Determination Date. 
 (ii)
If the rate described in clause (i) above does not appear on Reuters Page EURIBOR01, EURIBOR will be determined on the basis of the rates, at approximately 11:00 a.m., Brussels time, on the relevant EURIBOR Interest Determination Date, at which
deposits of the following kind are offered to prime banks in the Euro-Zone interbank market by the principal Euro-Zone office of each of four major banks in that market selected by the Company: euro deposits having a maturity of three months
beginning on such Interest Reset Date and in a principal amount of not less than €1,000,000 that is representative for a single transaction in such market at such time. The Paying and Calculation Agent will request the principal Euro-Zone
office of each of these banks to provide a quotation in writing of its rate. If at least two quotations are provided in writing, EURIBOR for such EURIBOR Interest Determination Date will be the arithmetic mean (rounded upwards) calculated by the
Paying and Calculation Agent of such quotations. 

  
 A-2 

 (iii) If fewer than two quotations are provided as described in clause
(ii) above, EURIBOR for the relevant EURIBOR Interest Determination Date will be the arithmetic mean of the rates for loans of the following kind to leading Euro-Zone banks quoted in writing, at approximately 11:00 a.m., Brussels time, on such
EURIBOR Interest Determination Date, by three major banks in the Euro-Zone selected by the Company: loans of euro having a maturity of three months beginning on such Interest Reset Date and in a principal amount of not less than €1,000,000 that
is representative for a single transaction in such market at such time. 
 (iv) If fewer than three banks selected by
the Company are quoting as described in clause (iii) above, EURIBOR shall be the EURIBOR in effect on such EURIBOR Interest Determination Date (or, in the case of the first Interest Reset Date, the initial Base Rate). 

Upon request of the Holder to the Paying and Calculation Agent, the Paying and Calculation Agent will provide the interest rate then in effect
on this Note and, if determined, the interest rate that will become effective on the next Interest Reset Date. 
 All percentages resulting
from any calculation with respect to this Note will be rounded upward or downward, as appropriate, to the next higher or lower one hundred-thousandth of a percentage point (e.g., 9.876541% (or .09876541) being rounded down to 9.87654% (or .0987654)
and 9.876545% (or .09876545) being rounded up to 9.87655% (or .0987655)). All amounts used in or resulting from any calculation with respect to this Note will be rounded upward or downward, as appropriate, to the nearest cent, in the case of euro
amounts or U.S. dollars, or to the nearest corresponding hundredth of a unit, in the case of a currency other than euro amounts or U.S. dollars, with one-half cent or one-half of a corresponding hundredth of a unit or more being rounded upward. 

The Company has initially appointed The Bank of New York Mellon, London Branch, as the Paying and Calculation Agent to act as Paying Agent and
calculation agent with respect to the Notes, but the Company may, in its sole discretion, appoint any other institution (including any Affiliate of the Company) to serve as any such agent from time to time, without any prior notice to any Holder.
The Company will give the Trustee prompt written notice of any change in any such appointment. 
 Interest on this Note will be computed on
the basis of a 360-day year and the actual number of days in the period for which interest is being calculated. 
 The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Note (or one or more Predecessor Notes) is registered on the Security Register at the close of
business on the Regular Record Date for such interest, which shall be the fifteenth calendar day, whether or not a Business Day, immediately preceding the related Interest Payment Date, except as provided in Section 2.07 of the Supplemental
Indenture. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Note (or one or more Predecessor Notes) is
registered at the close of business on a Special Record Date for the 

  
 A-3 

 
payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of this Note not less than 10 days prior to such Special Record Date, or be paid at any
time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Notes of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said
Indenture. 
 Payment of the principal of (and premium, if any) and interest on this Note will be made at the office or agency of the
Company maintained for that purpose in accordance with the Indenture, which shall initially be the corporate trust office of the Paying and Calculation Agent, in euro in immediately available funds; provided, however, that at the option of
the Company, payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or by wire transfer to an account maintained by the Person entitled thereto as specified
in the Security Register, and provided further that if the euro is unavailable to the Company or, in the case of the Guarantees, the Guarantor due to the imposition of exchange controls or other circumstances beyond the Company’s or the
Guarantor’s control or if the euro is no longer being used by the then-member states of the European Economic and Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or
within the international banking community, then all payments in respect of this Note shall be made in U.S. dollars until the euro is again available to the Company or, in the case of the Guarantees, the Guarantor or so used. In such circumstances,
the amount payable on any date in euro will be converted into U.S. dollars on the basis of the most recently available Market Exchange Rate for the euro. 

This Note is fully and unconditionally guaranteed by Danaher Corporation, a corporation duly organized and existing under the laws of
the State of Delaware (the “Guarantor”), as provided in the Indenture. 
 Reference is hereby made to the further
provisions of this Note set forth on the reverse hereof, which further provisions shall for all purposes have the same effect as if set forth at this place. 

Unless the certificate of authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this
Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-4 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its
corporate seal. 

Dated:                         
                 
  

			
	DH EUROPE FINANCE S.A.
		
	By:	 	 
		
	Name:	 	 
	Title:	 	 

  
 A-5 

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein described in the within-mentioned Indenture. 

Dated:                         
                         
 THE
BANK OF NEW YORK MELLON TRUST COMPANY, N.A., 
 as Trustee 

By:                         
                             

Authorized Officer 

  
 A-6 

 REVERSE OF NOTE 

This Note is one of a duly authorized issue of Securities of the Company (herein called the “Notes”), issued and to be issued
in one or more series under a Base Indenture, dated as of July 8, 2015 (herein called the “Base Indenture”), among the Company, the Guarantor and The Bank of New York Mellon Trust Company, N.A., as Trustee (herein called the
“Trustee,” which term includes any successor trustee under the Indenture), as amended and supplemented by the Second Supplemental Indenture, dated as of June 30, 2017 (herein called the “Supplemental
Indenture,” which term shall have the meaning assigned to it in such instrument, and together with the Base Indenture, herein called the “Indenture”) and reference is hereby made to the Indenture for a statement of the
respective rights, limitations of rights, duties and immunities thereunder of the Company, the Guarantor, the Trustee and the Holders of the Notes and of the terms upon which the Notes are, and are to be authenticated and delivered. This Note is one
of the series designated on the face hereof initially limited in aggregate principal amount to €250,000,000. The Notes are unsecured general obligations of the Company. 

1. Redemption Upon Changes in Withholding Taxes; Additional Amounts 

The provisions of Sections 1501 and 1502 of the Base Indenture and Sections 2.08 and 3.02 of the Supplemental Indenture shall apply to this
series of Notes. 
 Whenever the payment of the principal of or interest or any other amounts on, or in respect of, this Note is mentioned,
in any context, such mention shall be deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof pursuant to the terms of the Indenture, and
express mention of the payment of Additional Amounts in any provision of this series of Notes shall not be construed as excluding the payment of Additional Amounts in those provisions thereof where such express mention is not made. 

2. No Optional Redemption 
 Except as set
forth in Section 1 of this Note and in Section 3.02 of the Supplemental Indenture, the Company may not redeem the Notes of this Series prior to the Maturity Date. 

3. Change of Control Triggering Event 

If a Change of Control Triggering Event occurs, unless the Notes of this series have become redeemable as described in Section 3.02 of
the Supplemental Indenture, Holders of the Notes of this series will have the right to require the Company to repurchase all or any part (equal to €100,000 or an integral multiple of €1,000 in excess thereof) of their Notes pursuant to the
offer described below (the “Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal amount of Notes
repurchased plus accrued and unpaid interest, if any, on the Notes repurchased to the date of purchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, or, at the Company’s
option, prior to the date of the consummation of any Change of Control, but after public announcement of the transaction that constitutes or may constitute the Change of Control, the Company will be required to mail a notice to Holders of the Notes,
with a copy to the Trustee, describing the 

  
 A-7 

 
transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which date will be
no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required by the Indenture and described in such notice. The notice shall, if
mailed prior to the date of the consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Triggering Event occurring on or prior to the Change of Control Payment Date. 

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

(i) accept for payment all of the Notes, or portions of the Notes, properly tendered pursuant to the Change of Control
Offer; 
 (ii) deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all of the
Notes, or portions of the Notes, properly tendered; and 
 (iii) deliver or cause to be delivered to the Trustee the
Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes, or portions of Notes, being repurchased. 

The Paying Agent will promptly mail to each Holder of Notes properly tendered the Change of Control Payment for such Notes, and the Trustee
will promptly authenticate and mail (or cause to be transferred by book-entry) to each such Holder a new Note equal in principal amount to any unpurchased portion of any Notes surrendered; provided that each new Note will be in a principal amount of
€100,000 or an integral multiple of €1,000 in excess thereof. The Company will not be required to make an offer to repurchase the Notes upon a Change of Control Triggering Event if a third party makes such an offer in the manner, at the
times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all Notes properly tendered and not withdrawn under its offer. 

In addition, the Company will not repurchase any Notes if there has occurred and is continuing on the Change of Control Payment Date an Event
of Default under the Indenture, other than a default in the payment of the Change of Control Payment upon a Change of Control Triggering Event. 
 4. No
Sinking Fund 
 The Notes are not entitled to the benefit of any sinking fund. 

5. Defeasance and Discharge 
 The
Indenture contains provisions for defeasance and discharge and for defeasance at any time of certain restrictive covenants and Events of Default with respect to this Note upon compliance with certain conditions set forth in the Indenture. 

  
 A-8 

 6. Guarantee 

This Note is fully and unconditionally guaranteed by the Guarantor, as provided in Article 14 of the Indenture. 

7. Modification and Waiver 
 The
Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the Guarantor and the rights of the Holders of the Notes of each series to be affected under
the Indenture at any time by the Company, the Guarantor and the Trustee with the consent of the Holders of a majority in principal amount of the Notes at the time Outstanding of each series to be affected. The Indenture also contains provisions
permitting the Holders of specified percentages in principal amount of the Notes of each series at the time Outstanding, on behalf of the Holders of all Notes of such series, to waive compliance by the Company and the Guarantor with certain
provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Note shall be conclusive and binding upon such Holder and upon all future Holders of this Note and of
any Note issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Note. Without notice to or consent of any Holder, the parties thereto may amend or
supplement the Indenture and the Notes to, among other things, cure any ambiguity, defect or inconsistency, provide for uncertificated Notes in addition to or in place of certificated Notes, or make any other change that does not adversely affect
the rights of any Holder of a Note. 
 8. Events of Default 

If an Event of Default with respect to the Notes shall occur and be continuing, the principal of the Notes may be declared due and payable in
the manner and with the effect provided in the Indenture. 
 9. Remedies 

As provided in and subject to the provisions of the Indenture, the Holder of this Note shall not have the right to institute any proceeding
with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to the Notes of
this series, the Holders of not less than 25% in principal amount of the Notes of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered
the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Notes of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to
institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Note for the enforcement of any payment of principal hereof or any
premium or interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no provision
of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Note at the times, place and rate, and in the coin or currency,
herein prescribed. 

  
 A-9 

 10. Transfer and Exchange 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Note is registrable in the Security
Register, upon surrender of this Note for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Note are payable, duly endorsed by, or accompanied by a written
instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Notes of this series and of like tenor, of authorized
denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 
 The Notes of this
series are issuable only in registered form without coupons in denominations of €100,000 or an integral multiple of €1,000 thereof. As provided in the Indenture and subject to certain limitations therein set forth, Notes of this series are
exchangeable for a like aggregate principal amount of Notes of this series and of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. 

No service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to
cover any tax or other governmental charge payable in connection therewith. 
 Prior to due presentment of this Note for registration of
transfer, the Company, the Guarantor, the Trustee and any agent of the Company, the Guarantor or the Trustee may treat the Person in whose name this Note is registered as the owner hereof for all purposes, whether or not this Note be overdue, and
none of the Company, the Guarantor, the Trustee nor any such agent shall be affected by notice to the contrary. 
 A copy of the Security
Register shall be maintained by the Company at its registered office, in order to comply with Luxembourg law (the “Duplicate Register”). In case of discrepancy between the Security Register and the Duplicate Register, the Duplicate
Register shall prevail for Luxembourg law purposes. 
 11. Governing Law 

THIS NOTE SHALL BE DEEMED TO BE A CONTRACT MADE UNDER THE LAWS OF THE STATE OF NEW YORK, AND FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE
WITH THE LAWS OF SAID STATE. FOR THE AVOIDANCE OF DOUBT, THE APPLICABILITY OF ARTICLES 86 TO 94-8 OF THE LUXEMBOURG LAW DATED AUGUST 10, 1915 ON COMMERCIAL COMPANIES, AS AMENDED, SHALL BE EXCLUDED. 

  
 A-10 

 12. Defined Terms 

All terms used in this Note which are defined in the Indenture shall have the meanings assigned to them in the Indenture. As used in this
Note, the term “Predecessor Note” shall have the meaning assigned to the term “Predecessor Security” in the Indenture. 

  
 A-11 

 ASSIGNMENT 
  

	
	FOR VALUE RECEIVED, the undersigned assigns and transfers this Note to:
	
	 
	
	 
	
	(Insert assignee’s social security or tax identification number)
	
	 
	
	 
	
	 
	
	(Insert address and zip code of assignee) and irrevocably appoints
	
	 
	
	 
	
	 
	
	agent to transfer this Note on the books of the Company. The agent may substitute another to act for him or her.

  

							
				
	Date:                          	 		 		 	
		 		 	Signature:  	 	 

							
				
		 		 	Signature Guarantee:  	 	 

 (Sign exactly as your name appears on the other side of this Note) 

  
 A-12 

 SIGNATURE GUARANTEE 

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar, which requirements include
membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Security Registrar in addition to, or in substitution for,
STAMP, all in accordance with the Securities Exchange Act of 1934, as amended. 

  
 A-13 

 SCHEDULE OF INCREASES OR DECREASES IN NOTE 

The initial principal amount of this Note is €         . The following increases or decreases in the principal
amount of this Note have been made: 
  

									
	 Date
	  	 Amount of

decrease in

principal
 amount of
this
 Note
	  	 Amount of

increase in

principal
 amount of
this
 Note
	  	 Principal

amount of this
 Note
following
 such decrease

or increase
	  	 Signature of
authorized

officer or

Trustee

  
 A-14 

 EXHIBIT B 

[IF THIS NOTE IS TO BE A GLOBAL SECURITY, INSERT:] 
 UNLESS THIS
SECURITY IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR BANK, S.A./N.V., AS OPERATOR OF THE EUROCLEAR SYSTEM (“EUROCLEAR”) AND CLEARSTREAM BANKING, S.A. (“CLEARSTREAM” AND, TOGETHER WITH EUROCLEAR,
“EUROCLEAR/CLEARSTREAM”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR IN SUCH OTHER NAME AS IS
REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE BANK OF NEW YORK MELLON, LONDON BRANCH, AS COMMON DEPOSITARY FOR THE ACCOUNT OF EUROCLEAR/CLEARSTREAM (AND ANY PAYMENT IS MADE TO THE BANK OF NEW YORK DEPOSITORY (NOMINEES) LIMITED OR TO SUCH OTHER
ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF EUROCLEAR/CLEARSTREAM), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, THE BANK OF NEW YORK
DEPOSITORY (NOMINEES) LIMITED, HAS AN INTEREST HEREIN. 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND
IS REGISTERED IN THE NAME OF THE COMMON DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY
PERSON OTHER THAN SUCH COMMON DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 
 DH EUROPE
FINANCE S.A. 
 1.200% Senior Note due 2027 
  

					
	No.                                     
 	  		  	€                                     
 
			
		  		  	CUSIP: 23290Y AE6
		  		  	Common Code: 163716259
		  		  	ISIN: XS1637162592

 DH Europe Finance S.A., a public limited liability company (société anonyme) duly
organized and existing under the laws of Luxembourg, having its registered office at 1 B Heienhaff, L-1736 Senningerberg, Grand Duchy of Luxembourg and registered with the Luxembourg Trade and Companies Register under number B 197470 (herein called
the “Company,” which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to             , or
registered assigns, the principal sum set forth in the Schedule of Increases or Decreases in Note attached hereto on June 30, 2027, and to pay interest thereon from June 30, 2017 or from the immediately preceding

  
 B-1 

 
Interest Payment Date to which interest has been paid or duly provided for, annually in arrears on June 30 of each year, commencing June 30, 2018 at the rate of 1.200% per annum,
until the principal hereof is paid or made available for payment. Interest shall be computed on the basis of the payment convention ACTUAL/ACTUAL (ICMA) as defined in the rulebook of the International Capital Markets Association and in accordance
with the Supplemental Indenture. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Note (or one or more Predecessor Notes) is
registered on the Security Register at the close of business on the Regular Record Date for such interest, which shall be the fifteenth calendar day, whether or not a Business Day, immediately preceding the related Interest Payment Date, except as
provided in Section 2.07 of the Supplemental Indenture. 
 Any such interest not so punctually paid or duly provided for will forthwith
cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Note (or one or more Predecessor Notes) is registered at the close of business on a Special Record Date for the payment of such
Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of this Note not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of
any securities exchange on which the Notes of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and interest on this Note will be made at the office or agency of the Company
maintained for that purpose in accordance with the Indenture, which shall initially be the corporate trust office of the Paying and Calculation Agent, in euro in immediately available funds; provided, however, that at the option of the
Company, payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register or by wire transfer to an account maintained by the Person entitled thereto as specified in
the Security Register, and provided further that if the euro is unavailable to the Company or, in the case of the Guarantees, the Guarantor due to the imposition of exchange controls or other circumstances beyond the Company’s or the
Guarantor’s control or if the euro is no longer being used by the then-member states of the European Economic and Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or
within the international banking community, then all payments in respect of this Note shall be made in U.S. dollars until the euro is again available to the Company or, in the case of the Guarantees, the Guarantor or so used. In such circumstances,
the amount payable on any date in euro will be converted into U.S. dollars on the basis of the most recently available Market Exchange Rate for the euro. 

The Company has initially appointed The Bank of New York Mellon, London Branch, as the Paying Agent to act as such agent with respect to the
Notes, but the Company may, in its sole discretion, appoint any other institution (including any Affiliate of the Company) to serve as any such agent from time to time, without any prior notice to any Holder. The Company will give the Trustee prompt
written notice of any change in any such appointment. 

  
 B-2 

 This Note is fully and unconditionally guaranteed by Danaher Corporation, a corporation
duly organized and existing under the laws of the State of Delaware (the “Guarantor”), as provided in the Indenture. 

Reference is hereby made to the further provisions of this Note set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the
Trustee referred to on the reverse hereof by manual signature, this Note shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed under its corporate seal. 

Dated:                         
 
  

			
	DH EUROPE FINANCE S.A.
		
	By:	 	
                     
    

  

			
		
	Name:	 	  

	Title:	 	  

  
 B-3 

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

This is one of the Notes of the series designated therein described in the within-mentioned Indenture. 

Dated:                         
 
 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., 
 as
Trustee 

By:                         
                 
 Authorized Officer 

  
 B-4 

 REVERSE OF NOTE 

This Note is one of a duly authorized issue of Securities of the Company (herein called the “Notes”), issued and to be
issued in one or more series under a Base Indenture, dated as of July 8, 2015 (herein called the “Base Indenture”), among the Company, the Guarantor and The Bank of New York Mellon Trust Company, N.A., as Trustee (herein called
the “Trustee,” which term includes any successor trustee under the Indenture), as amended and supplemented by the Second Supplemental Indenture, dated as of June 30, 2017 (herein called the “Supplemental
Indenture,” which term shall have the meaning assigned to it in such instrument, and together with the Base Indenture, herein called the “Indenture”) and reference is hereby made to the Indenture for a statement of the
respective rights, limitations of rights, duties and immunities thereunder of the Company, the Guarantor, the Trustee and the Holders of the Notes and of the terms upon which the Notes are, and are to be authenticated and delivered. This Note is one
of the series designated on the face hereof initially limited in aggregate principal amount to €600,000,000. The Notes are unsecured general obligations of the Company. 

1. Optional Redemption 
 At any time and
from time to time prior to March 30, 2027, the Company shall have the right to redeem the Notes, in whole or in part, at its option, at a redemption price equal to the greater of: 

(i) 100% of the principal amount of the Notes to be redeemed; and 

(ii) the sum of the present values of the Remaining Scheduled Payments on the Notes to be redeemed (not including any
portion of the payments of interest that will be accrued and unpaid to and including the Redemption Date) discounted to the Redemption Date on an annual basis (ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate plus 15 basis
points, plus accrued and unpaid interest, if any, on the principal amount of the Notes being redeemed to, but excluding, the Redemption Date. 

On or after March 30, 2027, the Company shall have the right, at its option, to redeem the Notes, in whole or in part, at any time and
from time to time, at a redemption price equal to 100% of the principal amount of the Notes, plus accrued and unpaid interest, if any, on the principal amount of the Notes being redeemed to, but excluding, the Redemption Date. 

The Company will mail notice of any redemption to the registered Holders of the Notes to be redeemed not less than 30 nor more than 60 days
prior to the Redemption Date. If the Notes are only partially redeemed pursuant to Section 3.01 of the Supplemental Indenture, the Notes to be redeemed will be selected by the Trustee in such manner as in its sole discretion it shall deem
appropriate and fair, subject to any applicable Depositary procedures. 
 If money sufficient to pay the redemption price of all of the
Notes (or a portion thereof) to be redeemed on the Redemption Date is deposited with the Trustee or Paying Agent on or before the Redemption Date as provided herein and in the Indenture, then on and after such Redemption Date, interest will cease to
accrue on such Notes (or such portion thereof) called for redemption. 

  
 B-5 

 In the event of redemption of this Note in part only, a new Note or Notes for the unredeemed
portion hereof shall be issued in the name of the Holder hereof upon the cancellation hereof. 
 2. Redemption Upon Changes in Withholding Taxes;
Additional Amounts 
 The provisions of Sections 1501 and 1502 of the Base Indenture and Sections 2.08 and 3.02 of the Supplemental
Indenture shall apply to this series of Notes. 
 Whenever the payment of the principal of or interest or any other amounts on, or in
respect of, this Note is mentioned, in any context, such mention shall be deemed to include mention of the payment of Additional Amounts to the extent that, in such context, Additional Amounts are, were or would be payable in respect thereof
pursuant to the terms of the Indenture, and express mention of the payment of Additional Amounts in any provision of this series of Notes shall not be construed as excluding the payment of Additional Amounts in those provisions thereof where such
express mention is not made. 
 3. No Other Redemption 

Except as set forth in Sections 1 and 2 of this Note and in Article 3 of the Supplemental Indenture, the Company may not redeem the Notes
prior to the Maturity Date. 
 4. Change of Control Triggering Event 

If a Change of Control Triggering Event occurs, unless the Notes of this series have become redeemable as described in Sections 3.01
and 3.02 of the Supplemental Indenture, Holders of the Notes of this series will have the right to require the Company to repurchase all or any part (equal to €100,000 or an integral multiple of €1,000 in excess thereof) of their Notes
pursuant to the offer described below (the “Change of Control Offer”) on the terms set forth herein. In the Change of Control Offer, the Company will be required to offer payment in cash equal to 101% of the aggregate principal
amount of Notes repurchased plus accrued and unpaid interest, if any, on the Notes repurchased to the date of purchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, or, at the
Company’s option, prior to the date of the consummation of any Change of Control, but after public announcement of the transaction that constitutes or may constitute the Change of Control, the Company will be required to mail a notice to
Holders of the Notes, with a copy to the Trustee, describing the transaction or transactions that constitute or may constitute the Change of Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which
date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required by the Indenture and described in such notice. The notice
shall, if mailed prior to the date of the consummation of the Change of Control, state that the offer to purchase is conditioned on the Change of Control Triggering Event occurring on or prior to the Change of Control Payment Date. 

On the Change of Control Payment Date, the Company will be required, to the extent lawful, to: 

  
 B-6 

 (i) accept for payment all of the Notes, or portions of the Notes,
properly tendered pursuant to the Change of Control Offer; 
 (ii) deposit with the Paying Agent an amount equal to
the Change of Control Payment in respect of all of the Notes, or portions of the Notes, properly tendered; and 

(iii) deliver or cause to be delivered to the Trustee the Notes properly accepted together with an Officers’
Certificate stating the aggregate principal amount of Notes, or portions of Notes, being repurchased. 
 The Paying Agent will
promptly mail to each Holder of Notes properly tendered the Change of Control Payment for such Notes, and the Trustee will promptly authenticate and mail (or cause to be transferred by book-entry) to each such Holder a new Note equal in principal
amount to any unpurchased portion of any Notes surrendered; provided that each new Note will be in a principal amount of €100,000 or an integral multiple of €1,000 in excess thereof. The Company will not be required to make an offer
to repurchase the Notes upon a Change of Control Triggering Event if a third party makes such an offer in the manner, at the times and otherwise in compliance with the requirements for an offer made by the Company and such third party purchases all
Notes properly tendered and not withdrawn under its offer. 
 In addition, the Company will not repurchase any Notes if there has
occurred and is continuing on the Change of Control Payment Date an Event of Default under the Indenture, other than a default in the payment of the Change of Control Payment upon a Change of Control Triggering Event. 

5. No Sinking Fund 
 The Notes are not
entitled to the benefit of any sinking fund. 
 6. Defeasance and Discharge 

The Indenture contains provisions for defeasance and discharge and for defeasance at any time of certain restrictive covenants and Events of
Default with respect to this Note upon compliance with certain conditions set forth in the Indenture. 
 7. Guarantee 

This Note is fully and unconditionally guaranteed by the Guarantor, as provided in Article 14 of the Indenture. 

8. Modification and Waiver 
 The
Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the Guarantor and the rights of the Holders of the Notes of each series to be affected under
the Indenture at any time by the Company, the Guarantor and the Trustee with the consent of the Holders of a majority in principal amount of the Notes at the time Outstanding of each series to be affected. The Indenture also contains provisions
permitting the Holders of specified percentages in 

  
 B-7 

 
principal amount of the Notes of each series at the time Outstanding, on behalf of the Holders of all Notes of such series, to waive compliance by the Company and the Guarantor with certain
provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Note shall be conclusive and binding upon such Holder and upon all future Holders of this Note and of
any Note issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Note. Without notice to or consent of any Holder, the parties thereto may amend or
supplement the Indenture and the Notes to, among other things, cure any ambiguity, defect or inconsistency, provide for uncertificated Notes in addition to or in place of certificated Notes, or make any other change that does not adversely affect
the rights of any Holder of a Note. 
 9. Events of Default 

If an Event of Default with respect to the Notes shall occur and be continuing, the principal of the Notes may be declared due and payable in
the manner and with the effect provided in the Indenture. 
 10. Remedies 

As provided in and subject to the provisions of the Indenture, the Holder of this Note shall not have the right to institute any proceeding
with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to the Notes of
this series, the Holders of not less than 25% in principal amount of the Notes of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered
the Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Notes of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to
institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Note for the enforcement of any payment of principal hereof or any
premium or interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no provision
of this Note or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Note at the times, place and rate, and in the coin or currency,
herein prescribed. 
 11. Transfer and Exchange 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Note is registrable in the Security
Register, upon surrender of this Note for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Note are payable, duly endorsed by, or accompanied by a written
instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new Notes of this series and of like tenor, of authorized
denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

  
 B-8 

 The Notes of this series are issuable only in registered form without coupons in denominations of
€100,000 or an integral multiple of €1,000 thereof. As provided in the Indenture and subject to certain limitations therein set forth, Notes of this series are exchangeable for a like aggregate principal amount of Notes of this series and
of like tenor of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made
for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Note for registration of transfer, the Company, the Guarantor, the Trustee and any agent of the Company, the
Guarantor or the Trustee may treat the Person in whose name this Note is registered as the owner hereof for all purposes, whether or not this Note be overdue, and none of the Company, the Guarantor, the Trustee nor any such agent shall be affected
by notice to the contrary. 
 A copy of the Security Register shall be maintained by the Company at its registered office, in order
to comply with Luxembourg law (the “Duplicate Register”). In case of discrepancy between the Security Register and the Duplicate Register, the Duplicate Register shall prevail for Luxembourg law purposes. 

12. Governing Law 
 THIS NOTE SHALL BE
DEEMED TO BE A CONTRACT MADE UNDER THE LAWS OF THE STATE OF NEW YORK, AND FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE WITH THE LAWS OF SAID STATE. FOR THE AVOIDANCE OF DOUBT, THE APPLICABILITY OF ARTICLES 86 TO 94-8 OF THE LUXEMBOURG LAW DATED
AUGUST 10, 1915 ON COMMERCIAL COMPANIES, AS AMENDED, SHALL BE EXCLUDED. 
 13. Defined Terms 

All terms used in this Note which are defined in the Indenture shall have the meanings assigned to them in the Indenture. As used in
this Note, the term “Predecessor Note” shall have the meaning assigned to the term “Predecessor Security” in the Indenture. 

  
 B-9 

 ASSIGNMENT 
  

	
	FOR VALUE RECEIVED, the undersigned assigns and transfers this Note to:
	
	 
	
	 
	
	(Insert assignee’s social security or tax identification number)
	
	 
	
	 
	
	 
	
	(Insert address and zip code of assignee) and irrevocably appoints
	
	 
	
	 
	
	 
	
	agent to transfer this Note on the books of the Company. The agent may substitute another to act for him or her.

  

							
				
	Date:                                     
     	 		 		 	
		 		 	Signature: 	 	 

  

							
				
		 		 	Signature Guarantee: 	 	 

 (Sign exactly as your name appears on the other side of this Note) 

  
 B-10 

 SIGNATURE GUARANTEE 

Signatures must be guaranteed by an “eligible guarantor institution” meeting the requirements of the Security Registrar,
which requirements include membership or participation in the Security Transfer Agent Medallion Program (“STAMP”) or such other “signature guarantee program” as may be determined by the Security Registrar in addition to,
or in substitution for, STAMP, all in accordance with the Securities Exchange Act of 1934, as amended. 

  
 B-11 

 SCHEDULE OF INCREASES OR DECREASES IN NOTE 

The initial principal amount of this Note is € . The following increases or decreases in the principal amount of this Note have been made: 

 

									
	 Date
	  	 Amount of

decrease in

principal
 amount of
this
 Note
	  	 Amount of

increase in

principal
 amount of
this
 Note
	  	 Principal

amount of this
 Note
following
 such decrease

or increase
	  	 Signature of
authorized

officer or

Trustee

  
 B-12 

 EXHIBIT C 

[FORM OF GUARANTEE] 
 For
value received, the undersigned (the “Guarantor”), to the extent set forth in and subject to the terms of the Indenture, dated as of July 8, 2015 (the “Base Indenture”), among DH Europe Finance S.A., a public
limited liability company, société anonyme, duly organized and existing under the laws of Luxembourg, having its registered office at 1 B Heienhaff, L-1736 Senningerberg, Grand Duchy of Luxembourg and registered
with the Luxembourg Trade and Companies Register under number B 197470 (the “Company”), the Guarantor and The Bank of New York Mellon Trust Company, N.A., as Trustee (herein called the Trustee, which term includes any successor
trustee under the Indenture) and the Second Supplemental Indenture, among the Company, the Guarantor and the Trustee (the “Supplemental Indenture,” and together with the Base Indenture, the “Indenture”), irrevocably
and unconditionally guarantees to each Holder and to the Trustee and its successors and assigns (1) the full and punctual payment when due, whether at Stated Maturity, by acceleration, by redemption or otherwise, of all obligations of the
Company under the Indenture (including obligations to the Trustee) and the Notes, whether for payment of principal of, interest on, premium, if any, or Additional Amounts, if any, on the Notes and all other monetary obligations of the Company under
the Indenture and the Notes and (2) the full and punctual performance within applicable grace periods of all other obligations of the Company whether for fees, expenses, indemnification or otherwise under the Indenture and the Notes.

 The obligations of the Guarantor to the Holders and to the Trustee pursuant to this Guarantee and the Indenture are expressly set
forth in Article 14 of the Indenture, and reference is hereby made to the Indenture for the precise terms and limitations of this Guarantee. Each Holder of the Notes to which this Guarantee is endorsed, by accepting such Notes, agrees to and shall
be bound by such provisions. 
 All terms used and not otherwise defined in this Guarantee which are defined in the Indenture shall have the
meanings assigned to them in the Indenture. 
 IN WITNESS WHEREOF, the Guarantor has caused this Guarantee to be signed by a duly authorized
officer. 
  

			
	DANAHER CORPORATION, as Guarantor

  

			
		
	By:	 	 

 
			
	Authorized Signatory

  
 C-1EX-4.3

 Exhibit 4.3 

EXECUTION VERSION 
  

 
 PAYING AND
CALCULATION AGENCY AGREEMENT 
 Dated June 30, 2017 

among 
 DH Europe Finance S.A.

 as Issuer 
 Danaher
Corporation 
 as Guarantor 
 and

 The Bank of New York Mellon, London Branch as Paying and Calculation Agent 

and 
 The Bank of New York Mellon
Trust Company N.A. 
 as Trustee 
  

 

 THIS PAYING AND CALCULATION AGENCY AGREEMENT (this “Agreement”) is made as of
June 30, 2017, among DH Europe Finance S.A. (the “Issuer”), whose principal office is at 1B Heienhaff, L-1736 Senningerberg, Grand Duchy of Luxembourg, Danaher Corporation (the “Guarantor”), whose principal
office is at 2200 Pennsylvania Avenue, N.W., Suite 800W, Washington, D.C. 20037-1701, The Bank of New York Mellon, London Branch, as Paying and Calculation Agent (the “Paying and Calculation Agent”), whose principal office is at One
Canada Square, London E 1 4 5AL, United Kingdom and The Bank of New York Mellon Trust Company, N.A., as Trustee (the “Trustee”), whose principal office is at 2 North LaSalle, Suite 1020, Chicago, Illinois 60602. 

WHEREAS, the Issuer proposes to issue €600,000,000 aggregate principal amount of 1.200% senior notes due 2027 (the “2027
Notes”) and €250,000,000 aggregate principal amount of floating rate senior notes due 2022 (the “Floating Rate Notes” and, together with the 2027 Notes, the “Notes”), in each case, on the date hereof,
pursuant to that certain indenture dated as of July 8, 2015 (the “Base Indenture”) among the Issuer, the Guarantor and the Trustee, and that certain second supplemental indenture among the Issuer, the Guarantor, and the Trustee
(the “Supplemental Indenture” and together with the Base Indenture, the “Indenture”), the forms of which Indenture and Notes are attached hereto as Annex A; and 

WHEREAS, solely with respect to the Notes, the Issuer wishes to appoint the Paying and Calculation Agent, as set forth above, upon the terms
and subject to the conditions set forth herein; 
 NOW, THEREFORE, in consideration of the mutual promises contained herein, the parties
hereto agree as follows: 
 1. DEFINITIONS 

1.1 All capitalized terms used herein, but not defined, shall have the meanings given to them in the Indenture. 

1.2 In addition, the following terms shall have the following meanings: 

“Business Day” means any day other than a Saturday or Sunday, (i) which is not a day on which banking institutions in The
City of New York or London are authorized or required by law, regulation or executive order to close and (ii) in the event that any payment by the Issuer of the principal of and interest on the Notes is to be made in euro, on which the
Trans-European Automated Real Time Gross Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open. 

“Code” means the US Internal Revenue Code of 1986, as amended. 

“FATCA Compliant Entity” means an entity not subject to FATCA Withholding Tax. 

“FATCA Withholding Tax” means any withholding or deduction pursuant to an agreement described in Section 1471(b) of the
Code or otherwise imposed pursuant to Sections 1471 through 1474 of the Code (or any regulations or agreements thereunder or official interpretations thereof) or any intergovernmental agreement between the United States and another jurisdiction
facilitating the implementation thereof (or any law implementing such an intergovernmental agreement). 
 References to the records of
Euroclear Bank S.A./N.V. (“Euroclear”) and Clearstream Banking S.A. (“Clearstream”) shall be to the records that each of Euroclear and Clearstream holds for its customers which reflect the amount of such
customers’ interests in the Notes. 
 2. APPOINTMENT OF PAYING AND CALCULATION AGENT AND AS COMMON DEPOSITARY 

The Issuer hereby appoints the Paying and Calculation Agent at its office specified above as the Paying and Calculation Agent solely in
respect of the Notes and as the common depositary for Euroclear and Clearstream for the Notes, in each case, upon the terms and conditions herein contained, and the Paying and Calculation Agent accepts such appointments. In the event of any
inconsistency between the Indenture and this Agreement, the terms of this Agreement (including the Annexes attached hereto) shall prevail. 

 3. PAYMENT 

3.1 In order to provide for all payments due on the Notes as the same shall become due, the Issuer shall cause to be paid to the Paying and
Calculation Agent, no later than 10:00 a.m. London time one Business Day prior to the due date for the payment of each Note, at such bank as the Paying and Calculation Agent shall previously have notified to the Issuer, an amount in immediately
available funds in the currency of payment sufficient to meet all payments due on such Notes. 
 3.2 The Issuer hereby authorizes and
directs the Paying and Calculation Agent, solely from the amounts paid to it pursuant to this Section 3, to make or cause to be made all payments on the Notes in accordance with the terms thereof. Such payments shall be made to the Holder or
Holders of Notes in accordance with the terms of the Notes, the provisions contained in this Agreement and the procedures of Euroclear and Clearstream. All interest payments and Additional Amounts, if any, in respect of the Notes will be made by the
Paying and Calculation Agent on the relevant Interest Payment Date (as set forth in the Note) to the Holders in whose names the Notes are registered at the close of business (in New York) on the record date specified in the Notes next preceding the
relevant Interest Payment Date or such other date as is provided in the Notes. So long as the Notes are represented by one or more global certificates and registered in the name of a common depository for Euroclear and Clearstream or its nominee,
all interest payments and Additional Amounts, if any, on the Notes shall be made by the Paying and Calculation Agent by wire transfer of immediately available funds in Euro to Euroclear and Clearstream. 

3.3 The Paying and Calculation Agent will pay the principal amount of each Note on the applicable maturity date or upon any redemption date
with respect thereto, together with accrued and unpaid interest and Additional Amounts, if any, due at maturity or such redemption date, if any, upon presentation and surrender of such Note on or after the maturity date or redemption date thereof to
the Paying and Calculation Agent, or as specified in the Notes. 
 3.4 If for any reason the amounts received by the Paying and Calculation
Agent are insufficient to satisfy all claims in respect of all payments then due on the Notes, the Paying and Calculation Agent shall forthwith notify the Issuer, and the Paying and Calculation Agent shall not be obliged to pay any such claims until
the Paying and Calculation Agent has received from the Issuer the full amount of the monies then due and payable in respect of such Notes. 

3.5 The Paying and Calculation Agent hereby agrees that: 
  

	 	(a)	it will hold all sums held by it as Paying and Calculation Agent for the payment of the principal of or interest and Additional Amounts, if any, on the Notes in trust uninvested for the benefit of the Holders of the
Notes entitled thereto, or for the benefit of the Trustee, as the case may be, until such sums shall be paid out to such Holders or otherwise as provided in Section 3.6 below and in the Indenture; 

 

	 	(b)	it will promptly give the Trustee notice of: (x) an Issuer deposit for the payment of principal of or interest, and Additional Amounts, if any, on the Notes, (y) any failure by the Issuer in the making of any
deposit for the payment of principal of or interest, and Additional Amounts, if any, on the Notes that shall have become due and payable, and (z) any default by the Issuer in making any payment of the principal of or interest, and Additional
Amounts, if any, on the Notes where the same shall be due and payable as provided in the Notes; and 

  

	 	(c)	 At any time after an Event of Default by the Issuer in the making of any payment of principal of, or interest on,
or any Additional Amounts with respect to the Notes shall have occurred (after giving effect to any applicable grace period under the Notes and the Indenture), the Paying and Calculation Agent shall, if so required by notice in writing given by the
Trustee to the Paying and Calculation Agent: (y) thereafter, until otherwise instructed by the Trustee, act as agent of the Trustee under the terms of the Indenture; and/or (z) deliver all Notes and all sums, documents and

  
 2 

	 	
records held by the Paying and Calculation Agent in respect of the Notes to the Trustee or as the Trustee shall direct in such notice; provided that such notice shall be deemed not to
apply to any document or record which the Paying and Calculation Agent is obliged not to release by any applicable law or regulation. 

3.6 Notwithstanding the foregoing, 
  

	 	(a)	if any Note is presented or surrendered for payment to the Paying and Calculation Agent and the Paying and Calculation Agent has delivered a replacement therefor or has been notified that the same has been replaced, the
Paying and Calculation Agent shall as soon as is reasonably practicable notify the Issuer in writing of such presentation or surrender and shall not make payment against the same until it is so instructed by the Issuer and has received the amount to
be so paid; and 

  

	 	(b)	the Paying and Calculation Agent shall cancel each Note against surrender of which it has made full payment and shall deliver each Note so cancelled by it to the Trustee upon its request therefor. 

3.7 In no event, shall the Paying and Calculation Agent be obliged to make any payments hereunder if it has not received the full amount of
any such payment. 
 4. CALCULATION OF INTEREST 

4.1 The Paying and Calculation Agent shall calculate the amount of interest payable on the Notes in the manner and at the times set forth in
Annex A and in the Prospectus Supplement in respect of the Notes attached hereto as Annex B. 
 4.2 As soon as practicable after each
Interest Determination Date (as defined in the Notes), the Paying and Calculation Agent will cause to be forwarded to the Issuer and the Trustee information regarding the interest rates, the interest periods, the amount of interest for each interest
period and the relevant Interest Payment Date. The Paying and Calculation Agent will, upon the written request of any Holder of any Note, provide the interest rate then in effect and, if determined, the interest rate which will become effective for
the next interest period with respect to such Note. 
 4.3 In no event shall the interest rate be less than the minimum rate, if any, or
more than the maximum rate, if any, designated in the applicable pricing supplement, or more than the maximum rate permitted by New York law, as the same may be modified by United States law of general application. 

5. INDEMNITY 
 5.1 Each of the Issuer and
the Guarantor, jointly and severally, shall indemnify and keep indemnified the Paying and Calculation Agent against any losses, liabilities, costs (including reasonable fees and expenses of counsel), taxes (other than taxes attributable to income),
claims, actions or demands incurred by it as a result of or in connection with its appointment or the exercise of its powers and duties under this Agreement or in respect of the Issuer’s issue of Notes, except to the extent resulting from the
Paying and Calculation Agent’s bad faith, gross negligence or willful misconduct. Promptly after the receipt by the Paying and Calculation Agent of notice of any demand or claim or the commencement of any action, suit, proceeding or
investigation, the Paying and Calculation Agent shall provide such notice to the Issuer; provided that the Paying and Calculation Agent’s failure to provide such notice shall, to the extent that the Issuer or the Guarantor, as
applicable, is prejudiced as a result of such failure, relieve the Issuer or the Guarantor of its obligation to indemnify and keep indemnified the Paying and Calculation Agent pursuant to this Section 5.1. 

5.2 The Issuer, in its sole discretion, may elect to assume the defense of any such claim, in which case the Paying and Calculation Agent
shall cooperate in the defense of such claim. The Paying and Calculation Agent may have separate counsel in any such defense, but the fees and expenses of any such counsel shall be at the expense of the Paying and Calculation Agent, unless
(i) the employment of such counsel has been specifically authorized in writing by the Issuer or (ii) the named parties to any such action (including any impleaded parties) 

  
 3 

 
include both the Paying and Calculation Agent and the Issuer or any affiliate of the Issuer, and such Paying and Calculation Agent shall have reasonably concluded that, in the written opinion of
counsel, an actual conflict of interest exists between the Paying and Calculation Agent and the Issuer or such affiliate of the Issuer. Neither the Issuer nor the Guarantor shall be required to pay for or agree to any settlement without its
respective written consent. 
 5.3 In connection with its execution of and acting under this Agreement, the Trustee is entitled to all
rights, privileges, protections, benefits, immunities and indemnities (i) provided to it under the Indenture and (ii) provided to the Paying and Calculation Agent hereunder. 

5.4 The indemnities contained in Section 5.1 shall survive the termination or expiry of this Agreement and the resignation or removal of
the Paying and Calculation Agent. 
 6. GENERAL 

6.1 In acting under this Agreement, the Paying and Calculation Agent shall not (a) be under any fiduciary duty towards any person,
(b) be responsible for or liable in respect of the authorization, validity or legality of any Note amount paid by it hereunder (except to the extent that any such liability is determined by a court of competent jurisdiction to have been
resulted from the Paying and Calculation Agent’s bad faith, gross negligence or wilful misconduct), (c) be under any obligation towards any person other than the Trustee and Issuer or (d) assume any relationship of agency or trust for
or with any Holder. 
 6.2 Except as otherwise permitted hereunder or as ordered by a court of competent jurisdiction or required by law or
otherwise instructed by the Issuer, the Paying and Calculation Agent shall be entitled to treat the registered Holder of any Note as the absolute owner of such Note for all purposes and make payments thereon accordingly. 

6.3 The Paying and Calculation Agent shall not exercise any lien, right of set-off or similar claim against any Holder of a Note in respect of
moneys payable by it under this Agreement. 
 6.4 The Paying and Calculation Agent may consult on any matter concerning its duties hereunder
any legal adviser selected by it, and the Paying and Calculation Agent shall not be liable in respect of anything done, or omitted to be done in good faith reliance on that legal adviser’s opinion; provided that, prior to taking or omitting to
take any action in reliance on such opinion, the Paying and Calculation Agent shall notify the Issuer of such proposed action or omission. At any time, the Paying and Calculation Agent may apply to any duly authorized representative of the Issuer
for a written instruction, and shall not be liable for action taken or omitted to be taken in good faith and in accordance with such instruction. 

6.5 The Paying and Calculation Agent shall be entitled to rely, and shall not be liable in respect of anything done or suffered by it in
reliance, on any notice, document, communication or information reasonably believed in good faith by it to be genuine and given by the proper parties. 

6.6 The Paying and Calculation Agent shall be obliged to perform only such duties as are specifically set forth herein and in the Notes, and
no implied duties or obligations shall be read into this Agreement or the Notes against the Paying and Calculation Agent. 
 6.7 Subject as
provided in Section 6.3 above, the Paying and Calculation Agent shall not be liable to account to the Issuer for any interest or other amounts in respect of funds received by it hereunder from the Issuer. Money held by the Paying and
Calculation Agent need not be segregated except as required by law. 
 6.8 No provision of this Agreement or the Notes shall require the
Paying and Calculation Agent to risk or expend its own funds, or to take any action which in its reasonable judgment would result in any expense or liability accruing to it. 

6.9 In no event will the Paying and Calculation Agent be responsible or liable for any failure or delay in the performance of its obligations
hereunder arising out of or caused by, directly or indirectly, forces beyond its 

  
 4 

 
control, including, acts of war or terrorism, civil or military disturbances, nuclear or natural catastrophes or acts of God, and interruptions, severe loss or malfunctions of utilities,
communications or computer (software and hardware) services; it being understood that the Paying and Calculation Agent will use reasonable best efforts to resume performance as soon as practicable. 

6.10 The Paying and Calculation Agent shall have no duty to enquire as to the performance of the covenants of the Issuer, nor shall it be
charged with knowledge of any default or Event of Default under the Indenture. 
 6.11 Notwithstanding any provision of this Agreement to
the contrary, the Paying and Calculation Agent will not in any event be liable for special, indirect, punitive or consequential loss or damage of any kind whatsoever (including but not limited to lost profits), whether or not foreseeable, even if
the Paying and Calculation Agent has been advised of the likelihood of such loss or damage and regardless of the form of action. 
 6.12
Except to the extent otherwise provided in this Agreement, the Paying and Calculation Agent shall incur no liability hereunder except to the extent such liability has been determined to arise from the Paying and Calculation Agent’s bad faith,
gross negligence or willful misconduct. 
 6.13 The Paying and Calculation Agent, its officers, directors, employees and shareholders may
become the owners of, or acquire any interest in, the Notes, with the same rights that it or they would have if it were not the Paying and Calculation Agent, and may engage or be interested in any financial or other transaction with the Issuer as
freely as if it were not the Paying and Calculation Agent. 
 6.14 The Paying and Calculation Agent shall retain the right not to act and
shall not be held liable for refusing to act unless it has received clear and reasonable documentation which complies with the terms of this Agreement. 

6.15 The Issuer will supply the Paying and Calculation Agent with the names and specimen signatures of its authorized persons. 

7. CHANGE OF PAYING AND CALCULATION AGENT 

7.1 At any time, other than on a day during the forty-five (45) day period preceding any payment date on the Notes, the Paying and
Calculation Agent may resign by giving at least forty-five (45) days’ prior written notice to the Issuer; and the Paying and Calculation Agent’s agency shall be terminated and its duties shall cease upon expiration of such forty-five
(45) days or such lesser period of time as shall be mutually agreeable to Paying and Calculation Agent and the Issuer. At any time, following at least forty-five (45) days’ prior written notice (or such lesser period of time as shall
be mutually agreeable to the Paying and Calculation Agent and the Issuer) from the Issuer, the Paying and Calculation Agent may be removed from its agency. Such removal shall become effective upon the expiration of the forty-five (45) day or
agreed lesser time period (provided that any such removal shall be immediate in case the Paying and Calculation Agent shall be adjudicated bankrupt or insolvent), and upon payment to the Paying and Calculation Agent of all amounts due and payable to
it in connection with its agency. In such event, following payment of its fees and expenses due and payable, the Paying and Calculation Agent shall deliver to the Issuer, or to the Issuer’s designated representative, all Notes (if any) and cash
(if any) belonging to the Issuer and, at the Issuer’s expense, shall furnish to the Issuer, or to the Issuer’s designated representative, such information regarding the status of the Issuer’s outstanding Notes as is reasonably
requested by the Issuer. 
 7.2 Any corporation or banking association into which the Paying and Calculation Agent may be merged or
consolidated or any corporation or banking association resulting from any merger or consolidation to which the Paying and Calculation Agent is a party or any corporation or banking association to which the Paying and Calculation Agent shall sell or
otherwise transfer all or substantially all of its corporate trust or agency assets shall on the date on which such merger, consolidation or transfer becomes effective, become the successor to the Paying and Calculation Agent under this Agreement
without the execution or filing of any paper or any further act on the part of the parties hereto. 

  
 5 

 8. COMPENSATION AND FEES 

8.1 The Issuer or the Guarantor, as applicable, will pay to the Paying and Calculation Agent from time to time, compensation as shall be
agreed to in writing between the Issuer and the Paying and Calculation Agent in connection with its duties hereunder, together with any applicable value added tax and stamp, issue, or other documentary taxes and duties. In addition, the Issuer or
the Guarantor, as applicable, shall reimburse the Paying and Calculation Agent, upon the Paying and Calculation Agent’s request, for all reasonable out of pocket expenses and disbursements incurred by the Paying and Calculation Agent in
accordance with the provisions of this Agreement (including the reasonable compensation, expenses and disbursements of any outside counsel for the Paying and Calculation Agent), except any expense or disbursement attributable to its gross
negligence, willful misconduct or bad faith. 
 9. NOTICES 

9.1 Each notice or communication under this Agreement shall be made in writing, by fax or e-mail or otherwise in accordance with this
Section 9. Each communication or document to be delivered to any party under this Agreement shall be sent to that party at the fax number, e-mail or address, and marked for the attention of the person (if any), from time to time designated by
that party to the Paying and Calculation Agent (or, in the case of the Paying and Calculation Agent, by it to each other party) for the purpose of this Agreement. The initial telephone number, fax number, e-mail, address and person so designated
are: 
 in the case of the Issuer, to it at: 

DH Europe Finance S.A. 
 1B,
Heienhaff, L-1736 Senningerberg 
 Grand Duchy of Luxembourg 

Attention: Director 
 Email:
karel.heeren@danaher.com 
 with a copy (which shall not constitute notice) to each of the Guarantor and Wilmer Cutler Pickering Hale and
Dorr LLP at their respective addresses set forth below 
 in the case of the Guarantor, to it at: 

c/o Danaher Corporation 
 2200
Pennsylvania Avenue, N.W., Suite 800W, 
 Washington, D.C. 20037-1701. 

Attention: Vice President-Treasurer 

Fax: (202) 828-0860 
 with a
copy (which shall not constitute notice) to: 
 Wilmer Cutler Pickering Hale and Dorr LLP 

1875 Pennsylvania Avenue, NW 

Washington, DC 20006 
 Attention:
Erika L. Robinson 
 E-mail: Erika.Robinson@wilmerhale.com 

in the case of the Paying and Calculation Agent, to it at: 

The Bank of New York Mellon, London Branch 

One Canada Square, London El4 5AL, United Kingdom 

Attention: Corporate Trust Administration 

Tel no: +44 (0) 207 964 5028 

Fax: +44 (0) 20 7964 2536 

E-mail: corpsovl@bnymellon.com 

  
 6 

 in the case of the Trustee, to it at: 

The Bank of New York Mellon Trust Company, N.A. 

2 North LaSalle, Suite 1020, Chicago, Illinois 60602. 

Attention: Corporate Finance 

Fax: (312) 827-8542 
 9.2
All notices under this Agreement shall be effective (if by fax) when receipt is confirmed by the recipient following enquiry by the sender and (if by e-mail or letter) when delivered, except that a communication received outside normal business
hours shall be deemed to be received on the next business day in the city in which the recipient is located, provided, however, that any notices or other communications to the Paying and Calculation Agent or the Trustee shall be deemed
effective only when actually received. 
 9.3 The Paying and Calculation Agent agrees to accept and act upon instructions or directions
pursuant to this Agreement sent by unsecured e-mail, PDF, facsimile transmission or other similar unsecured electronic methods, provided that the Paying and Calculation Agent shall have received an incumbency certificate listing persons
authorized to give such instructions or directions and containing specimen signatures of such authorized persons, which such incumbency certificate shall be amended and replaced whenever a person is to be added or deleted from the listing. Subject
to Section 5 and Section 6.12 of this Agreement, in no event shall the Paying and Calculation Agent be liable for any losses resulting from the Paying and Calculation Agent receiving from an authorized person via any non-secure method of
transmission or communication, such as by facsimile or e-mail. The Paying and Calculation Agent is authorized to comply with and rely upon any such notice, instruction or other communications reasonably believed by it to have been sent or given by
an authorized person. The Issuer shall use all reasonable endeavours to ensure that instructions transmitted to the Paying and Calculation Agent pursuant to this Agreement are complete and correct. Any instructions properly delivered pursuant to the
requirements of this Agreement shall be conclusively deemed to be valid instructions from the Issuer to the Paying and Calculation Agent for the purposes of this Agreement. 

10. GOVERNING LAW AND JURISDICTION; WAIVER OF JURY TRIAL 

10.1 The interpretation, validity and enforcement of this Agreement, and all legal actions brought under or in connection with the subject
matter of this Agreement, shall be governed by the laws of the State of New York. 
 10.2 Any court action brought under or in connection
with the subject matter of this Agreement shall be brought only in any federal or New York State court, in either case, sitting in the Borough of Manhattan, City of New York. Each of the Issuer and the Paying and Calculation Agent submits to the
exclusive jurisdiction of these courts and agrees not to commence any legal action under or in connection with the subject matter of this Agreement in any other court or forum. 

10.3 Each of the Issuer, the Trustee and the Paying and Calculation Agent waives any objection to the laying of the venue of any legal action
brought under or in connection with the subject matter of this Agreement in the Federal or state courts sitting in the Borough of Manhattan, City of New York, and agrees not to plead or claim in such courts that any such action has been brought in
an inconvenient forum. 
 10.4 EACH OF THE ISSUER, THE GUARANTOR, THE HOLDERS OF THE NOTES, THE TRUSTEE AND THE PAYING AND CALCULATION AGENT
HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTION CONTEMPLATED HEREBY. 

11. WITHHOLDING 
 11.1 Notwithstanding
any other provision of this Agreement, the Paying and Calculation Agent or Trustee (as applicable, “BNYM”) shall be required to make a deduction or withholding (including the deduction of FATCA Withholding Tax) from any payment
which it makes under this Agreement for or on account of any present 

  
 7 

 
or future taxes, duties or charges if and to the extent so required by any applicable law and any current or future regulations or agreements thereunder or official interpretations thereof or any
law implementing an intergovernmental approach thereto or by virtue of the relevant holder failing to satisfy any certification or other requirements in respect of the Notes (the “Applicable Law”), in which event BNYM shall make
such payment after such withholding or deduction has been made and shall account to the relevant authorities for the amount so withheld or deducted, and BNYM shall have no obligation to gross up any payment hereunder or pay any Additional Amount as
a result of such withholding tax. 
 11.2 If the Paying and Calculation Agent or Trustee is a “foreign financial institution” as
such term is defined under FATCA, then such Paying and Calculation Agent or Trustee must be or become, prior to receiving any payment from the Issuer under this Agreement, a FATCA Compliant Entity. Notwithstanding any other paragraph herein, any
additional, substitute or successor Paying and Calculation Agent or Trustee appointed under this Agreement that is a foreign financial institution must be a FATCA Compliant Entity. 

11.3 If, for any reason, the Paying and Calculation Agent or Trustee is not, or ceases to be, a FATCA Compliant Entity and, as a result, the
Issuer considers in its sole discretion that it may be required to deduct or withhold FATCA Withholding Tax in respect of any payment due on any Notes, then the Issuer will be entitled to redirect or reorganise any such payment in any way that it
sees fit in order that the payment may be made without such FATCA Withholding Tax. In order to comply with Applicable Law, the Company agrees: (i) to provide to BNYM reasonably sufficient information about holders or other applicable parties
and/or transactions (including any modification to the terms of the Notes), to the extent such information is in the possession of the Company, so BNYM can determine whether it has tax related obligations under Applicable Law and (ii) that BNYM
shall be entitled to make any withholding or deduction from payments under the transaction documents to the extent necessary to comply with Applicable Law. 

12. HEADINGS 
 12.1 The headings of the
Sections of this Agreement are inserted for convenience only and shall not constitute a part of or affect in any way the meaning or interpretation of this Agreement. 

13. COUNTERPARTS 
 13.1 This Agreement
may be executed by manual, PDF or other electronic signature in counterparts, each of which shall be an original and all of which, together, shall constitute one and the same instrument. 

[signature pages follow] 

  
 8 

 IN WITNESS WHEREOF the parties hereto have caused this Agreement to be duly executed as of the
day and year first above written. 
  

			
	 DH EUROPE FINANCE S.A.
 as
Issuer

		
	By:	 	/s/ Frank T. McFaden
		 	Name: Frank T. McFaden
		 	Title: Category A Director

  

			
	 DANAHER CORPORATION
 as
Guarantor

		
	By:	 	/s/ Daniel L. Comas
		 	Name: Daniel L. Comas
		 	 Title: Executive Vice President and Chief

          Financial Officer

 

			
	 THE BANK OF NEW YORK MELLON, LONDON BRANCH

as Paying Agent and Calculation Agent

		
	By:	 	/s/ Latoya S. Elvin
		 	Name: Latoya S. Elvin
		 	Title: Vice President

  

			
	 THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A.

as Trustee

		
	By:	 	/s/ Richard Tarnas
		 	Name: Richard Tarnas
		 	Title: Vice President

 [Signature Page to Paying and Calculation Agency Agreement] 

 ANNEX A 

FORMS OF NOTES AND INDENTURE 

(attached) 

 ANNEX B 

PROSPECTUS SUPPLEMENT 

(attached)

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