Document:

<PAGE>

                                                                   EXHIBIT 10.19

                             THE TJX COMPANIES, INC.

                             EXECUTIVE SAVINGS PLAN

                                 Third Amendment

      Pursuant to Section 9.1 of The TJX Companies, Inc. Executive Savings Plan
(the "ESP"), Section 11.5 of the ESP is hereby amended and clarified as follows,
effective as of January 1, 2004 except as hereinafter provided:

            "11.5. RETIREMENT EQUALIZATION BENEFITS. At the time a benefit is
      paid to a Participant under The TJX Companies, Inc. Retirement Plan (the
      "Retirement Plan") or The TJX Companies, Inc. Supplemental Executive
      Retirement Plan (the "SERP") (the "Retirement Plan" and the "SERP" being
      hereinafter referred to as the "Pension Plans"), the Participant shall be
      entitled to receive a retirement equalization benefit having a value equal
      to the difference between (a) the amount such Participant would have been
      entitled to receive under the Pension Plans if none of his or her Salary
      had been deferred under this Plan and (b) the amount such Participant
      actually receives under the Pension Plans. Such retirement equalization
      benefit shall be payable in the same form that the Participant elects to
      receive benefits under the Pension Plans. Such retirement equalization
      benefit shall not be payable to the extent that the Participant is
      entitled to receive an equalization benefit of comparable value under the
      SERP or any other plan. For the avoidance of doubt, any benefit under the
      Retirement Plan that is supplemental to the formula benefit described in
      Article 7 thereof shall be treated as an equalization benefit for purposes
      of this Section 11.5 unless the E.C.C. expressly provides otherwise."

The action set forth herein with respect to the ESP is not intended to
constitute a "material modification" of the ESP as that term is used in Section
885(d)(2)(B) of the American Jobs Creation Act of 2004, and shall be construed
and applied accordingly.

      IN WITNESS WHEREOF, The TJX Companies, Inc. has caused this instrument of
amendment to be executed by its duly authorized officer this 16th day of
December, 2004.

                                     THE TJX COMPANIES, INC.

                                     By:       /s/ Donald G. Campbell
                                               ----------------------

                                     Title:    Senior Executive Vice President
                                               -------------------------------
<PAGE>

                            THE TJX COMPANIES, INC.
                             EXECUTIVE SAVINGS PLAN

                                FOURTH AMENDMENT

      The TJX Companies, Inc. hereby amends its Executive Savings Plan (the
"Plan"), effective as of January 1, 2005, by adding the following new Section
11.5:

            "11.5 SECTION 409A. Reference is made to Section 409A of the Code
      and to the guidance (including transition rules and exemptive relief
      provisions) issued thereunder ("Section 409A"). Consistent with Section
      409A, it is intended that with respect to amounts deferred under the Plan
      prior to January 1, 2005 that were both earned and vested prior to January
      1, 2005, the Plan will be administered consistent with the objective of
      preserving for such amounts "grandfathered" status under Section 409A,
      that is, the status of deferred compensation not subject to the
      requirements and limitations of Section 409A. All other deferrals under
      the Plan shall be administered in compliance with the requirements of
      Section 409A. It is intended in this regard that the Plan will be
      comprehensively amended to comply with final rules under Section 409A
      following the issuance of such rules or at such earlier time as may be
      required under Section 409A or determined by the Administrator. Without
      limiting the generality of the foregoing, the Plan shall be deemed amended
      by this Section 11.5 to permit, with respect to any deferrals hereunder
      that are subject to Section 409A, any transition-period elections
      permitted under Section 409A that are authorized by the Senior Executive
      Vice President - Chief Administrative and Business Development Officer of
      the Company, the Senior Executive Vice President - Chief Financial Officer
      of the Company, or the successor of either (a "specified Company officer")
      and any cancellations and withdrawals of such any such amounts that are
      authorized by a specified Company officer, except that any such action by
      a specified Company officer that relates to his or her own benefit shall
      require the approval of a member of the E.C.C. Notwithstanding the
      foregoing, neither the Company nor any of its officers or directors, nor
      any other person charged with administrative responsibilities under the
      Plan, shall be liable to any Eligible Person or to any beneficiary of any
      Eligible Person by reason of the failure of any deferral hereunder to
      comply with, or be exempt from, the requirements of Section 409A."

      IN WITNESS WHEREOF, The TJX Companies, Inc. has caused this instrument of
amendment to be executed by its duly authorized officer this 12th day of
December, 2005.

                                             THE TJX COMPANIES, INC.

                                   By:       /s/ Donald G. Campbell
                                             ----------------------
                                   Title:    Senior Executive Vice President<PAGE>

                                                                     Exhibit 4.1

                                 AMENDMENT NO. 2
                                       TO
                                RIGHTS AGREEMENT

This AMENDMENT NO. 2 TO RIGHTS AGREEMENT (the "Amendment") is entered into as of
March 24, 2006, between Idera Pharmaceuticals, Inc., a Delaware corporation (the
"Company"), and Mellon Investor Services LLC, a New Jersey limited liability
company, as Rights Agent (the "Rights Agent"). Capitalized terms not otherwise
defined herein shall have the meanings given them in the Rights Agreement, dated
as of December 10, 2001, as amended (the "Rights Agreement"), between the
parties hereto.

                                    RECITALS

WHEREAS, the Board has determined that it is in the best interest of the Company
to amend the Rights Agreement to modify the definition of Exempted Person to
exclude a certain stockholder of the Company from such definition in specified
circumstances; and

WHEREAS, the Company has determined that the Rights Agreement be amended in
accordance with Section 27 of the Rights Agreement, as set forth herein, and the
Rights Agent is hereby directed to join in the amendment to the Rights Agreement
as set forth herein.

                                    AGREEMENT

NOW THEREFORE, the parties hereto, intending to be legally bound, hereby agree
as follows:

1. Section 1(oo) of the Rights Agreement is hereby amended to read in its
entirety as follows:

     "(oo) "Exempted Person" shall mean Baker Brothers Investments, together
          with all of its Affiliates and Associates ("Baker Brothers"), unless
          and until such time as Baker Brothers, directly or indirectly, becomes
          the Beneficial Owner of more than 35,000,000 shares (subject to
          appropriate adjustment to reflect any stock split, reverse stock
          split, stock dividend, combination, reclassification or other similar
          recapitalization affecting such shares) of the Common Stock
          (disregarding for purposes of this calculation any shares of Common
          Stock purchased by Baker Brothers pursuant to the participation right
          (the "Participation Right") set forth in Section 5.2 of that certain
          Common Stock Purchase Agreement, dated March 24, 2006, by and among
          the Company and the purchasers listed in Exhibit A thereto (the "CSP
          Agreement")). Notwithstanding the preceding sentence, if following the
          date on which its Participation Right terminates in accordance with
          the CSP Agreement, Baker Brothers, directly or indirectly, is or
          becomes the Beneficial Owner of less than 14% of the Common Stock then
          outstanding, Baker Brothers immediately shall cease to be an Exempted
          Person. The Company acknowledges that the Rights Agent has no
          knowledge of the CSP Agreement.

<PAGE>

2. Section 3(a) of the Rights Agreement is hereby amended by deleting the first
sentence of Section 3(a) in its entirety and inserting in lieu thereof the
following sentence:

          "Section 3. Issuance of Rights.

          (a) Until the earlier of (i) the Close of Business on the tenth
     Business Day (or such later date as may be determined by the Board) after
     the Stock Acquisition Date (or, if the tenth Business Day after the Stock
     Acquisition Date occurs before the Record Date, the close of business on
     the Record Date), or (ii) the Close of Business on the tenth Business Day
     (or such later date as may be determined by action of the Board) after the
     date that a tender or exchange offer (other than a Permitted Offer) by any
     Person (other than the Company, any Subsidiary of the Company, any employee
     benefit plan of the Company or of any Subsidiary of the Company, or any
     Person organized, appointed or established by the Company for or pursuant
     to the terms of any such plan) is first published or sent or given within
     the meaning of Rule 14d-2 of the General Rules and Regulations under the
     Exchange Act, if upon consummation thereof, such Person would be the
     Beneficial Owner of 15% or more of the shares of Common Stock then
     outstanding (the earlier of (i) and (ii) being herein referred to as the
     "Distribution Date"), (x) the Rights will be evidenced by the certificates
     for the Common Stock registered in the names of the holders of the Common
     Stock (which certificates for Common Stock shall be deemed also to be
     certificates for Rights) and not by separate certificates, and (y) the
     Rights will be transferable only in connection with the transfer of the
     underlying shares of Common Stock (including a transfer to the Company)."

3. Except as amended hereby, the Rights Agreement shall remain unchanged and
shall remain in full force and effect.

4. This Amendment may be executed in any number of counterparts, each of which
shall be an original, but all of which together shall constitute one instrument.

5. This Amendment shall be deemed to be a contract made under the laws of the
State of Delaware and for all purposes shall be governed by and construed in
accordance with the laws of Delaware applicable to contracts made and to be
performed entirely within Delaware; provided, however, that all rights, duties
and obligations of the Rights Agent shall be governed by and construed in
accordance with the laws of the State of New York applicable to contracts made
and to be performed entirely within such state.

                  [remainder of page intentionally left blank]

<PAGE>

IN WITNESS WHEREOF, the parties have caused this Amendment to be executed by
their respective duly authorized representatives as of the date first above
written.

IDERA PHARMACEUTICALS, INC.

By: /s/ Sudhir Agrawal
    ---------------------------------
Name: Sudhir Agrawal
Title: Chief Executive Officer

MELLON INVESTORS SERVICES LLC,
as Rights Agent

By: /s/ John J. Boryczki
    ---------------------------------
Name: John J. Boryczki
Title: Client Relationship Executive

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00100-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00100-of-00352.parquet"}]]