Document:

EX-10.1

 Exhibit 10.1 
 SECOND AMENDMENT TO LEASE 
 THIS SECOND AMENDMENT TO LEASE
(“Second Amendment”) is made and entered into as of the 15th day of February, 2013, by and between MULLROCK 3 TORREY PINES, LLC, a Delaware limited liability company (“Landlord”) and OREXIGEN THERAPEUTICS, INC., a
Delaware corporation (“Tenant”). 
 R E C I T A L S:

 A. Landlord and Tenant entered into that certain Office Lease dated as of December 7, 2007 (the “Original
Lease”), as amended by (i) that certain First Amendment to Lease dated as of September 23, 2008 by and between Landlord and Tenant (“First Amendment”), and (ii) that certain Partial Lease Termination
Agreement dated as of February 22, 2012 by and between Landlord and Tenant (“Agreement”), whereby Landlord leased to Tenant and Tenant leased from Landlord certain office space located in that certain building located and
addressed at 3344 North Torrey Pines Court, San Diego, California (the “Building”). The Original Lease, as modified by the First Amendment and the Agreement, may be referred to herein as the “Lease.”

 B. By this Second Amendment, Landlord and Tenant desire to extend the term of the Lease and to otherwise modify the Lease as
provided herein. 
 C. Unless otherwise defined herein, capitalized terms as used herein shall have the same meanings as given
thereto in the Lease. 
 NOW, THEREFORE, in consideration of the foregoing recitals and the mutual covenants contained herein,
and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 
 A G R E E M E N T: 
 1. The Existing Premises. Landlord and Tenant hereby agree that pursuant to the Lease, Landlord currently leases to Tenant and Tenant currently leases from Landlord 22,229 rentable and 19,818
usable square feet (consisting of 9,628 rentable and 8,584 usable square feet of space on the first (1st) floor of the Building and 12,601 rentable and 11,234 usable square feet of space on the second (2nd) floor of the Building) and commonly known as Suites 100 and 200 (collectively, the “Premises”),
as more particularly described in the Lease. 
 2. Extended Term. The term of the Lease shall be extended such that the
Lease shall terminate on August 31, 2017 (“Lease Expiration Date”). The period from September 1, 2013 through the Lease Expiration Date shall be referred to herein as the “Extended Term.” Tenant’s
Extension Option (set forth in Section 2.2 of the Original Lease), shall remain in full force and effect except that the Extension Notice shall be provided (if at all) no earlier than the date which is twelve (12) months and not later than
the date which is nine (9) months, prior to the expiration of the Extended Term. 
 3. Monthly Basic Rent. During
the Extended Term, Tenant shall pay, in accordance with the provisions of this Section 3, but subject to abatement pursuant to Section 4 below, Monthly Basic Rent for the Premises as follows: 

 

					
	 Months of Lease Term
	  	 Monthly Basic Rent
	  	 Monthly Basic Rent Per

Rentable Square Foot

	 *09/01/13 – 08/31/14
	  	$83,358.75	  	$3.75
	 09/01/14 – 08/31/15
	  	$85,803.94	  	$3.86
	 09/01/15 – 08/31/16
	  	$88,471.42	  	$3.98
	 09/01/16 – 08/31/17
	  	$91,138.90	  	$4.10

  

	*	Subject to partial abatement as provided below. 

 4. Monthly Basic Rent Abatement. Notwithstanding anything to the
contrary contained in the Lease or in this Second Amendment, and provided that Tenant faithfully performs all of the terms and conditions of the Lease, as amended by this Second Amendment, Landlord hereby agrees to abate fifty percent (50%) of
Tenant’s obligation to pay Monthly Basic Rent for the first (1st), second
(2nd), third (3rd), fourth
(4th), fifth (5th), sixth (6th), seventh (7th), eighth (8th) and ninth (9th) full months of the Extended Term. During such abatement period, Tenant shall still be responsible for the
payment of all of its other monetary obligations under the Lease, as amended by this Second Amendment. In the event of a default by Tenant (beyond all applicable notice and cure provisions) under the terms of the Lease, as amended by this Second
Amendment, that results in early termination pursuant to the provisions of Section 23 of the Original Lease, then as part of the recovery set forth in Section 23 of the Original Lease, Landlord shall be entitled to the recovery of the pro
rata Monthly Basic Rent that was abated under the provisions of this Section 4. 
 5. Base Year. During the Extended
Term, for purposes of calculating Operating Expenses, the Base Year for the Premises shall be deemed changed to the calendar year 2013; provided, however, in no event shall Tenant be liable for any “Excess Expenses” (as defined in
Section 4.3 of the Original Lease) during the first twelve (12) months of the Extended Term. 
 6. Refurbishment of
Premises. Notwithstanding anything to the contrary contained herein, Tenant shall be entitled to renovate the then-existing improvements in the Premises in accordance with this Section 6 and otherwise in accordance with Section 12 of
the Original Lease. In connection therewith, Tenant shall be entitled to a refurbishment allowance (the “Refurbishment Allowance”) in the amount up to, but not exceeding, Fourteen Dollars ($14.00) per rentable square foot of the
Premises (i.e., an amount up to, but not exceeding, Three Hundred Eleven Thousand Two Hundred Six Dollars ($311,206.00) based on 22,229 rentable square feet in the Premises) for the costs relating to the design and construction of certain
renovations to the then-existing improvements in the Premises that are to be permanently affixed to the Premises (the “Refurbished Improvements”); provided, however, that the Refurbishment Allowance may also be utilized for low
voltage electrical work, wire/data cabling, audio/visual work and security system work. In no event shall Landlord be obligated to make disbursements under this Section 6 in a total amount which exceeds the Refurbishment Allowance. 

6.1 Refurbishment Allowance Items. The Refurbishment Allowance shall be disbursed by Landlord for the following items and costs
only (collectively, the “Refurbishment Allowance Items”): 
 (a) Payment of the fees of the architect and
engineer(s) retained by Tenant (if any), and payment of the fees incurred by, and the cost of documents and materials supplied by, Landlord and Landlord’s consultants (not to exceed the sum of Three Thousand Dollars ($3,000.00) for such fees
and costs of Landlord and Landlord’s consultants) in connection with the review of the plans and specifications prepared for the Refurbished Improvements (“Refurbishment Drawings”); 

(b) The payment of plan check, permit and license fees relating to construction of the Refurbished Improvements; 

(c) The cost of construction of the Refurbished Improvements, including, without limitation, testing and inspection costs, trash removal
costs, and contractors’ fees and general conditions; 
 (d) The Landlord Supervision Fee (as defined below); 

(e) The cost of any changes to the Refurbishment Drawings or Refurbished Improvements required by applicable building codes; 

(f) The cost of any construction manager retained by Tenant; and 

(g) Sales and use taxes and Title 24 fees. 

  
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 6.2 Disbursement of Refurbishment Allowance. Provided that Tenant is not in default
(beyond all applicable notice and cure provisions) on any of its obligations under the Lease, as amended herein, Landlord shall make a disbursement of the Refurbishment Allowance for Refurbishment Allowance Items for the benefit of Tenant and shall
authorize the release of monies for the benefit of Tenant as follows: 
 (a) Disbursement. Tenant shall deliver to
Landlord (not more frequently than every thirty (30) days): (i) a request for payment of Tenant’s general contractor (“Contractor”), which Contractor shall be retained by Tenant and shall be subject to Landlord’s
reasonable prior written approval, and which request shall be approved by Tenant, in a form to be provided by Landlord; (ii) invoices from all subcontractors, laborers, materialmen and suppliers used by Tenant in connection with the Refurbished
Improvements (such subcontractors, laborers, materialmen and suppliers, and the Contractor may be known collectively as “Tenant’s Agents”), for labor rendered and materials delivered to the Premises for the Refurbished
Improvements; (iii) executed conditional mechanics’ lien releases from the Contractor and all of Tenant’s Agents in such form and content as reasonably required by Landlord; and (iv) all other information reasonably requested by
Landlord. Tenant’s request for payment shall be deemed Tenant’s acceptance and approval of the work furnished and/or the materials supplied as set forth in Tenant’s payment request. Within thirty (30) days after Landlord’s
receipt of the applicable information described in items (i) through (iv) above, Landlord shall deliver a check made payable to Contractor (or, if so requested by Tenant, payable to Tenant) in payment of the amounts so requested by Tenant
(but in no event to exceed the amount of the Refurbishment Allowance), provided that and solely to the extent that Landlord does not dispute any request for payment based on non-compliance of any work with the Refurbishment Drawings, or due to any
substandard work. Landlord’s payment of such amounts shall not be deemed Landlord’s approval or acceptance of the work furnished or materials supplied as set forth in Tenant’s payment request. 

(b) Other Terms. Landlord shall only be obligated to make disbursements from the Refurbishment Allowance solely for Refurbishment
Allowance Items. All Refurbishment Allowance Items for which the Refurbishment Allowance has been made available shall be deemed Landlord’s property. Except as otherwise provided below, in no event shall Tenant be entitled to any credit for any
unused portion of the Refurbishment Allowance. All drafts of the Refurbishment Drawings shall be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld or delayed; Landlord shall reply to Tenant’s
plan approval request within five (5) business days of Landlord’s receipt of Tenant’s request. In addition, all of Tenant’s Agents shall be subject to Landlord’s prior written approval (which approval shall not be
unreasonably withheld), except that subcontractors of Landlord’s selection shall be retained by the Contractor to perform all life safety, mechanical, electrical, plumbing, structural and heating, ventilation and air conditioning work.
Notwithstanding anything in this Section 6 to the contrary, in no event will Tenant be entitled to receive any portion of the Refurbishment Allowance for Refurbished Improvements that have not been completed on or before August 31, 2014
(and as long as Tenant has complied with the requirements of Section 6.2(a) above on or before such date); provided, however, that any unused portion of the Refurbishment Allowance existing as of the earlier of August 31, 2014 and
completion of the Refurbished Improvements (but not to exceed One Hundred Fifty-Five Thousand Six Hundred Three Dollars ($155,603.00)) shall be applied by Landlord as a credit toward the Monthly Basic Rent first coming due thereafter under the
Lease. 
 (c) Landlord Supervision Fee. Tenant shall be responsible for a supervision fee (the “Landlord
Supervision Fee”) to Landlord in an amount equal to the product of (i) three percent (3%) and (ii) the total amount of the hard costs to construct the Refurbished Improvements (excluding soft costs). Such Landlord Supervision
Fee shall be deducted by Landlord from the Refurbishment Allowance. 
 6.3 No Rent Abatement. Tenant acknowledges that
the work to be performed by Tenant pursuant to this Section 6 above shall be performed (if at all) between the date of this Amendment and August 31, 2014, that Tenant shall be entitled to (but shall not be obligated to) conduct business
throughout the course of construction of such renovations and that Tenant shall not be entitled to any abatement of rent, nor shall Tenant be deemed to be constructively evicted from the Premises, as a result of the construction of such renovations.

 7. Right of First Offer to Lease. Tenant shall have a continuing (subject to the terms hereof) right of first offer
during the Extended Term (not including the Option Term, if applicable) with respect to available space (as such availability is determined by Landlord in its 

  
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sole but good faith discretion) containing a minimum of 5,000 rentable square feet (i) on the plaza level and third (3rd) floors of the Building and (ii) in the building located at 3366 North Torrey Pines Court (collectively,
“First Offer Space”). Notwithstanding the foregoing, the lease term for Tenant’s lease of the First Offer Space pursuant to Tenant’s exercise of such first refusal right of Tenant shall commence only following the
expiration or earlier termination of any existing lease pertaining to the First Offer Space, including any renewal or extension of any such existing lease, whether or not such renewal or extension is pursuant to an express written provision in such
lease, and regardless of whether any such renewal or extension is consummated pursuant to a lease amendment or a new lease, and (ii) such first refusal right shall be subordinate and secondary to all rights of expansion, first refusal, first
offer or similar rights granted to (x) the tenant of any such existing lease and (y) any other tenant of the Project, in either case, as of the date hereof (the rights described in items (i) and (ii), above to be known collectively as
“Superior Rights; provided, however, that except for the renewals of leases existing as of the date hereof pertaining to the First Offer Space by the following tenants, the First Offer Space is not subject to any Superior Rights: West
Health Incubator; Scripps Health; San Diego County Credit Union; Lyon & Associates; Bioedge; The Scripps Research Institute; Auspex; Thomas McNerney; and HLS. Tenant’s right of first offer shall be on the terms and conditions set forth
in this Section 7. 
 (a) Procedure for Offer. Landlord shall notify Tenant (the “First Offer
Notice”) from time to time when Landlord determines that Landlord shall commence the marketing of the First Offer Space in the Building because such space shall become or is expected to become available for lease to third parties, where (in
each such case) no holder of a Superior Right desires to lease such space. The First Offer Notice shall describe the space so offered to Tenant (the “First Offer Notice Space”) and shall set forth Landlord’s proposed economic
terms and conditions applicable to Tenant’s lease of the First Offer Notice Space (collectively, the “First Offer Economic Terms”). Notwithstanding the foregoing, Landlord’s obligation to deliver the First Offer Notice
shall not apply during the last nine (9) months of the Lease Term unless Tenant has delivered an Extension Notice pertaining to the extension of the Extended Term. In no event shall Landlord be obligated to provide a First Offer Notice for
space consisting of less than 5,000 rentable square feet. 
 (b) Procedure for Acceptance. If Tenant wishes to exercise
Tenant’s right of first offer with respect to the First Offer Notice Space, then within five (5) business days after delivery of such First Offer Notice to Tenant, Tenant shall deliver written notice to Landlord of Tenant’s exercise
of its right of first offer with respect to the entire First Offer Notice Space and on the First Offer Economic Terms contained therein. If Tenant does not exercise its right of first offer within the five (5) business day time period (on all
of the First Offer Economic Terms), then Landlord shall be free to lease the First Offer Notice Space (a “New Lease”) to anyone to whom Landlord desires on any terms Landlord desires and Tenant’s right of first offer shall (as
it pertains to the First Offer Notice Space) thereupon automatically terminate and this Section 7 (as it pertains to the First Offer Notice Space) shall be null and void and of no further force or effect; provided, however, that if Landlord
intends to enter into a lease upon terms which are, in the aggregate, materially more favorable to a prospective third (3rd) party tenant than those First Offer Economic Terms proposed by Landlord in the First Offer Notice to Tenant, then
Landlord shall first deliver written notice to Tenant (“Second Chance Notice”) providing Tenant with the opportunity to lease the First Offer Notice Space on such more favorable First Offer Economic Terms. For purposes hereof, First
Offer Economic Terms shall be materially more favorable to a third party if such First Offer Economic Terms reflect a net effective rental rate less than ninety-five percent (95%) of the net effective rental rate for such First Offer Notice
Space as those proposed by Landlord in the First Offer Notice to Tenant. Tenant’s failure to elect to lease the First Offer Notice Space upon such more favorable First Offer Economic Terms by written notice to Landlord within three
(3) business days after Tenant’s receipt of such Second Chance Offer Notice from Landlord shall be deemed to constitute Tenant’s election not to lease such space upon such more favorable First Offer Economic Terms, in which case
Landlord shall be entitled to lease such space to any third (3rd) party on terms no more favorable to the third (3rd) party than those set forth in the Second Chance Offer Notice. For purposes of this Section 7(b), “net
effective rental rate” shall mean the amount of rent received by Landlord after deducting for any allowances or concessions given to a tenant or Tenant (as the case may be), including without limitation the value of any work performed by
Landlord prior to the application of any tenant improvement allowance, and net of any operating expenses and taxes where applicable. Notwithstanding anything to the contrary contained herein, Tenant must elect

  
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to exercise its right of first offer, if at all, with respect to all of the space comprising the First Offer Notice Space offered by Landlord to Tenant at any particular time, and Tenant may not
elect to lease only a portion thereof or object to any of the First Offer Economic Terms. If Landlord does not enter into a lease or leases for all of the First Offer Space identified by Landlord in such First Offer Notice within six (6) months
after the date Landlord first delivered such First Offer Notice to Tenant, then Landlord shall submit to Tenant a new First Offer Notice with respect to any such unleased First Offer Space prior to the first time after such 6-month period that
Landlord intends to lease such space to another party, provided that no Superior Right holder wishes to lease such space in accordance with its Superior Rights in which event the foregoing procedures shall again apply following Tenant’s receipt
of such new First Offer Notice. 
 (c) Continuing Right. If the space offered in Landlord’s First Offer Notice is
only a portion of the First Offer Space, then Tenant shall retain its right of first offer pursuant to the terms of this Section 7 with respect to the remaining portion of the First Offer Space which has never been included in a Landlord’s
First Offer Notice when Landlord determines that such remaining First Offer Space is available for lease as set forth above. 

(d) Construction of First Offer Space. Tenant shall take the First Offer Space in its “As-Is” condition (unless
otherwise provided in the First Offer Notice as part of the First Offer Economic Terms), and Tenant shall be entitled to construct improvements in the First Offer Space at Tenant’s expense, in accordance with and subject to the provisions of
Section 12 of the Original Lease. 
 (e) Lease of First Offer Space. If Tenant timely exercises Tenant’s right
to lease the First Offer Space as set forth herein, Landlord and Tenant shall execute an amendment adding such First Offer Space to the Lease upon the First Offer Economic Terms set forth in Landlord’s First Offer Notice and upon the same
non-economic terms and conditions as applicable to the original Premises. Tenant shall commence payment of rent for the First Offer Space and the Lease Term of the First Offer Space shall commence upon the date of delivery of such space to Tenant.
The Lease Term for the First Offer Space shall be as provided in the First Offer Notice as part of the First Offer Economic Terms. 
 (f) No Defaults. The rights contained in this Section 7 shall be personal to the original tenant executing this Second Amendment (“Original Tenant”) and may only be exercised
by the Original Tenant (and not any assignee, sublessee or other transferee of the Original Tenant’s interest in the Lease) and only if Original Tenant is in occupancy of no less than seventy-five percent (75%) of the entire Premises then
leased by Original Tenant. In addition, at Landlord’s option and in addition to Landlord’s other remedies set forth in the Lease, at law and/or in equity, Tenant shall not have the right to lease the First Offer Space as provided in this
Section 7 if, as of the date of the First Offer Notice, or, at Landlord’s option, as of the scheduled date of delivery of such First Offer Space to Tenant, Tenant is in default under the Lease (as modified by this Second Amendment) beyond
the expiration of all applicable notice and cure periods. 
 8. Exterior Signage. Notwithstanding anything in the Lease
to the contrary, Tenant shall be entitled to maintain Tenant’s existing exterior signage during the Extended Term at no additional rental charge (i.e., the $500.00 monthly fee set forth in the Original Lease is hereby deleted). All of the other
terms, conditions and provisions of the Lease (pertaining to Tenant’s exterior signage) shall remain in full force and effect. 
 9. Brokers. Each party represents and warrants to the other that no broker, agent or finder negotiated or was instrumental in negotiating or consummating this Second Amendment other than The Muller
Company (“Landlord’s Broker”) and Hughes Marino (“Tenant’s Broker”). Landlord shall be solely responsible for any brokerage commissions and fees owing to Landlord’s Broker and Tenant’s Broker.
Each party further agrees to defend, indemnify and hold harmless the other party from and against any claim for commission or finder’s fee by any entity (other than Landlord’s Broker or Tenant’s Broker) who claims or alleges that they
were retained or engaged by the first party or at the request of such party in connection with this Second Amendment. 

  
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 10. Parking. Notwithstanding anything in the Lease to the contrary and in lieu of
Tenant’s parking rights set forth in the Lease, during the Extended Term, Tenant shall lease a total of forty-six (46) unreserved, uncovered parking privileges in the Building’s parking lot and fifteen (15) reserved, covered
parking privileges in the subterranean garage at the Project, all at no additional cost to Tenant, which parking privileges shall be subject to the provisions set forth in Section 6.2 of the Original Lease. Additionally, Tenant shall, subject
to availability (as such availability is determined by Landlord in its sole but good faith discretion), have the right to lease, on a month-to-month basis (terminable by either party on thirty (30) days prior written notice to the other), up to
five (5) additional unreserved, uncovered parking privileges in the Building’s parking lot at the Project at a cost of Sixty-Five Dollars ($65.00) per reserved, covered parking privilege per month. 

11. Condition of the Premises. Except as specifically set forth in Section 6 above, Tenant hereby agrees to accept the
Premises in its “as-is” condition and Tenant hereby acknowledges that Landlord, except as provided above in Section 6, shall not be obligated to provide or pay for any improvement work or services related to the improvement of the
Premises. Tenant also acknowledges that Landlord has made no representation or warranty regarding the condition of the Premises. 
 12. Letter of Credit. Landlord and Tenant acknowledge and agree that Tenant has previously deposited with Landlord a Letter of Credit in the current amount (“Stated Amount”) of One
Hundred Seventy Six Thousand Six Hundred Eighty and 47/100 Dollars ($176,680.47). On September 1, 2015 (the “Adjustment Date”) the Stated Amount shall, subject to the terms hereof and in lieu of the Adjustment Dates set forth
in the Original Lease, be reduced to Eighty Eight Thousand Three Hundred Forty and 24/100 Dollars ($88,340.24). However, if (i) a default (beyond the expiration of all applicable notice and cure periods) by Tenant occurs under the Lease (as
modified by this Second Amendment), or (ii) circumstances exist that would, with notice or lapse of time, or both, constitute a default by Tenant, and Tenant has failed to cure such default within the cure period permitted by Section 23 of
the Original Lease or such lesser time as may remain before the Adjustment Date as provided above, the Stated Amount shall not thereafter be reduced unless and until such default shall have been fully cured pursuant to the terms of the Lease, at
which time the Stated Amount shall be reduced as hereinabove described. In the event of such one-time, contingent reduction of the Stated Amount, Landlord shall hold the Letter of Credit (in the remaining Stated amount of $88,340.24) in accordance
with Section 5 of the Original Lease (as modified by the terms herein). 
 13. Signing Authority. Each individual
executing this Second Amendment on behalf of Tenant and Landlord hereby represents and warrants that it is a duly incorporated and existing entity qualified to do business in the State of California and that it has full right and authority to
execute and deliver this Second Amendment and that each person signing on behalf of Landlord and Tenant is authorized to do so. 

14. No Further Modification. Except as set forth in this Second Amendment, all of the terms and provisions of the Lease shall
remain unmodified and in full force and effect. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
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 IN WITNESS WHEREOF, this Second Amendment has been executed as of the day and year first
above written. 
  

									
	LANDLORD:	 	MULLROCK 3 TORREY PINES, LLC, a Delaware limited liability
company
			
		 	By:	 	 Mullrock 3 Torrey Pines Manager, LLC,
 a Delaware limited liability company
 Its Non-Member Manager

			
		 	By:	 	 Mullrock 3, LLC,
 a
Delaware limited liability company
 Its Sole Member

				
		 		 	By:	 	 Muller-Rock 3, LLC,

a California limited liability company
 Its
Managing Member

					
		 		 		 	By:	 	 /s/ Stephen J. Muller

		 		 		 	Name: Stephen J. Muller
		 		 		 	Title: Managing Member

  

									
	“TENANT”	 	 OREXIGEN THERAPEUTICS, INC.,
 a Delaware corporation
	 		 	
					
		 	By:	 	 /s/ Michael A. Narachi
	 		 	
		 		 	Name: Michael A. Narachi	 		 	
		 		 	Title: President & Chief Executive Officer	 		 	
					
		 	By:	 	 /s/ Joseph P. Hagan
	 		 	
		 		 	Name: Joseph P. Hagan	 		 	
		 		 	Title: Chief Business Officer	 		 	

  
 -7-EX-10.19A

 Exhibit 10.19A 
 SECOND AMENDMENT TO LEASE 
 THIS SECOND AMENDMENT TO LEASE (this
“Second Amendment”) is made as of April 9, 2013, by and between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation
(“Tenant”). 
 RECITALS 
 A. Landlord and Tenant are now parties to that certain Lease Agreement dated as of September 14, 2010, as amended by that certain First Amendment to Lease dated as of September 22, 2010,
and as further amended by that certain letter agreement dated August 2, 2012 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises (“Original Premises”) in a building located at 7000
Shoreline Court, South San Francisco, California. The Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B. Landlord and Tenant acknowledge and agree that, as of the date hereof, a portion of the Building consisting of approximately
19,177 rentable square feet, as shown on Exhibit A attached hereto (“Expansion Premises”), is currently subject to that certain Amended and Restated Lease Agreement between Landlord and Achaogen, Inc., a Delaware corporation
(“Achaogen”), dated December 29, 2010 (as the same may have been or may in the future may be amended, the “Achaogen Lease”). 
 C. Landlord and Tenant acknowledge that, prior to the Expansion Premises Commencement Date (as defined in Section 3 below), Tenant intends to enter into a sublease agreement with
Achaogen pursuant to which Tenant shall sublease the Expansion Premises from Achaogen prior to the Expansion Premises Commencement Date (the “Achaogen Sublease”), which Achaogen Sublease shall require Landlord’s written consent
in the form of a consent to sublease agreement by and among Landlord, Tenant and Achaogen (“Consent to Sublease”). 
 D. Landlord and Tenant desire, subject to the terms and conditions set forth below, to among other things, (i) extend the term of the Lease, and (ii) expand the Original Premises to
include the Expansion Premises. 
 NOW, THEREFORE, in consideration of the foregoing Recitals, which are
incorporated herein by this reference, the mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows:

  

	1.	Base Term. The Base Term of the Lease for the Premises (which, after the Expansion Premises Commencement Date, shall include the Expansion Premises) is
hereby extended until April 30, 2020 (the “Expiration Date”). 

  

	2.	Expansion Premises. In addition to the Original Premises, commencing on the Expansion Premises Commencement Date (as defined below), Landlord leases to
Tenant, and Tenant leases from Landlord, the Expansion Premises. 

  

	3.	 Delivery. The “Expansion Premises Commencement Date” shall be the earlier to occur of (i) April 1, 2014, or
(ii) the day after the termination of the Achaogen Lease, if the Achaogen Lease terminates prior to March 31, 2014; provided, however, that if the Achaogen Lease has terminated due to a casualty or Taking (as such term is defined in the
Achaogen Lease), such casualty or Taking shall be deemed to have occurred during the Base Term of the Lease and the rights and obligations of Landlord and Tenant with respect thereto shall be governed by Section 18 or
Section 19 of the Lease, as applicable. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Expansion Premises Commencement Date and the expiration date of the Term when such are established in the
form of the “Acknowledgement of 

  
 1 

	 	
Expansion Premises Commencement Date” attached hereto as Exhibit B; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect
Landlord’s rights hereunder. 

 Notwithstanding anything to the contrary contained herein, Tenant and Landlord
acknowledge and agree that the commencement of the Lease with respect to the Expansion Premises on or before April 1, 2014, is conditioned on the satisfaction of the following conditions precedent (“Conditions Precedent”): that
Achaogen enter into an amendment of the Achaogen Lease with Landlord, which amendment shall be acceptable to Landlord, in its reasonable discretion, pursuant to which Achaogen waives its right to extend the term of the Achaogen Lease with respect to
the Expansion Premises, and that Achaogen, Landlord and Tenant enter into the Consent to Sublease. Neither Landlord nor Tenant shall have any liability whatsoever to each other relating to or arising from Landlord’s inability or failure to
cause the Conditions Precedent to be satisfied. The execution and delivery by Landlord and Achaogen of an amendment of the Achaogen Lease pursuant to which Achaogen waives its right to extend the term thereof with respect to the Expansion Premises
shall be deemed to satisfy the foregoing condition with respect to the Achaogen Lease amendment. 
 Except as set forth in the
Lease or this Second Amendment: (i) Landlord shall have no obligation for any defects in the Expansion Premises; and (ii) Tenant’s occupancy of the Expansion Premises pursuant to the terms of the Achaogen Sublease shall be conclusive
evidence that Tenant accepts the Expansion Premises and that the Expansion Premises are in good condition. 
 Tenant agrees and
acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of all or any portion of the Expansion Premises, and/or the suitability of the Expansion Premises for the conduct of
Tenant’s business, and Tenant waives any implied warranty that the Expansion Premises are suitable for the Permitted Use. 
  

	4.	Definition of Premises. Commencing on the Expansion Premises Commencement Date, the defined term “Premises” on Page 1 of the Lease is
deleted in its entirety and replaced with the following: 

 “Premises: That portion of
the Project, containing approximately 48,405 rentable square feet (“RSF”), consisting of (i) approximately 29,228 rentable square feet (the “Original Premises”), and (ii) approximately 19,177 rentable
square feet (“Expansion Premises”), all as determined by Landlord, as shown on Exhibit A.” 
 As of
the Expansion Premises Commencement Date, Exhibit A to the Lease is amended to include Exhibit A attached to this Second Amendment. 
  

	5.	Base Rent. 

 a. Original Premises. Tenant shall continue to pay Base Rent for the Original Premises as provided for in the Lease through April 30, 2015. Commencing on May 1, 2015, Base Rent for the
Original Premises shall be an amount equal to $2.60 per rentable square foot of the Original Premises per month. Thereafter, on each May 1st during the Base Term (each an “Adjustment Date”), Base Rent for the Original Premises shall be
increased by multiplying the Base Rent payable with respect to the Original Premises immediately before such Original Premises Adjustment Date by 1.3% (the “Rent Adjustment Percentage”) and adding the resulting amount to the Base
Rent payable with respect to the Original Premises immediately before such Original Premises Adjustment Date. Base Rent for the Original Premises, as so adjusted, shall be due in equal monthly installments each in advance on the first day of each
and every calendar month during the applicable calendar year. 

  
 2 

 b. Expansion Premises. Commencing on the Expansion Premises Commencement Date, Base
Rent for the Expansion Premises shall be an amount equal to $2.90 per rentable square foot of the Expansion Premises per month; provided, however, that if the Expansion Premises Commencement Date occurs prior to April 1, 2014, Base Rent for the
Expansion Premises shall be equal to $1.70 per rentable square foot of the Expansion Premises per month through March 31, 2014. Commencing on May 1, 2015, Tenant shall pay Base Rent for the Expansion Premises at the same rate per rentable
square foot that Tenant is then paying for the Original Premises during the Base Term, as adjusted pursuant to Section 5(a) above. Base Rent for the Expansion Premises, as so adjusted, shall be due in equal monthly installments each in
advance on the first day of each and every calendar month during the applicable calendar year. 
 Notwithstanding
anything to the contrary contained in this Second Amendment, for the period commencing on April 1, 2014, through June 30, 2014, Tenant shall not be required to pay Base Rent for the Expansion Premises only. Commencing on July 1, 2014,
Tenant shall commence (or resume, as applicable) paying full Base Rent for the Expansion Premises pursuant to this Section 5(b). 
 c. TI Rent. In addition to the Tenant Improvement Allowance (as defined in the Work Letter attached to this Second Amendment as Exhibit C), Landlord shall, subject to the terms of the Work
Letter, make available to Tenant the Additional Tenant Improvement Allowance (as defined in the Work Letter) for the construction of the Tenant Improvements. Commencing on the first day of the month following the date on which any portion of the
Additional Tenant Improvement Allowance is funded to Tenant (“Initial Payment Date”) and continuing thereafter on the first day of each month of the Base Term, Tenant shall pay to Landlord the amount necessary to fully amortize the
amount of the Additional Tenant Improvement Allowance actually funded by Landlord, if any, in equal monthly payments with interest at a rate of 9% per annum over the remaining Base Term (“TI Rent”). If any portion of the
Additional Tenant Improvement Allowance is funded to Tenant after the Initial Payment Date, the monthly amount of TI Rent payable by Tenant shall be adjusted in order to fully amortize such amounts funded after the Initial Funding Date in equal
monthly payments with interest at a rate of 9% per annum over the remaining Base Term. 
  

	6.	Tenant’s Share of Operating Expenses. Tenant shall continue to pay Operating Expenses as provided for in the Lease through the day immediately
preceding the Expansion Premises Commencement Date. Commencing on the Expansion Premises Commencement Date, Tenant’s Share of Operating Expenses payable by Tenant under the Lease shall be increased by 14.06%, and commencing on May 1, 2015,
the total Tenant’s Share of Operating Expenses which shall be payable by Tenant under the Lease shall be equal to 35.49%. 

 Commencing on May 1, 2015, Tenant’s Share of each earthquake deductible or occurrence of uninsured earthquake damage affecting the Premises shall not exceed $7.50 per rentable square of the
Premises (including the Expansion Premises) (the “Current Cap”). On June 1, 2015, and on the first day of each month thereafter through the Expiration Date, the Current Cap shall be reduced by $0.125 per rentable square foot of
the Premises (including the Expansion Premises). Following earthquake damage to the Project during the period between April 1, 2015, and the Expiration Date, Tenant shall pay Tenant’s Share of any such deductible or uninsured damage in
equal monthly installments amortized over the balance of the Base Term. For the avoidance of doubt, the existing caps of insurance deductibles and uninsured earthquake damage set forth in the third full paragraph of Section 5 of the
Lease shall apply through April 30, 2015, and the caps provided for in this paragraph shall apply from May 1, 2015, through April 30, 2020, and shall thereafter be of no further force or effect. 

 

	7.	Intentionally Omitted. 

  
 3 

	8.	Right to Extend Term. As of the date of this Second Amendment, Section 39(a) of the Lease is hereby deleted and replaced with the following:

 “(a) Extension Right. Tenant shall have 1 right (“Extension Right”) to extend the
term of this Lease for 5 years (an “Extension Term”) on the same terms and conditions as this Lease (other than Base Rent, Tenant’s Share and the Work Letters) by giving Landlord written notice of its election to exercise the
Extension Right at least 9 months prior, and no earlier than 12 months prior, to the Expiration Date. 
 Notwithstanding anything
to the contrary contained in this Lease, if Tenant exercises its Extension Right hereunder, commencing on May 1, 2020, Tenant’s Share of each earthquake deductible or occurrence of uninsured earthquake damage affecting the Premises shall
not exceed $7.50 per rentable square of the Premises (the “Extension Cap”). On June 1, 2020, and on the first day of each month thereafter through the expiration of the Extension Term, the Extension Cap shall be reduced by
$0.125 per rentable square foot of the Premises. Following earthquake damage to the Project during the period between May 1, 2020, and the expiration of the Extension Term, Tenant shall pay Tenant’s Share of any such deductible or
uninsured damage in equal monthly installments amortized over the balance of the Extension Term. 
 Upon the commencement of the
Extension Term, Base Rent shall be payable at the Market Rate (as defined below). Base Rent shall thereafter be adjusted on each annual anniversary of the commencement of the Extension Term by a percentage as determined by Landlord and agreed to by
Tenant at the time the Market Rate is determined. As used herein, “Market Rate” shall mean the market rental rate for comparable laboratory space in South San Francisco, California, as determined by Landlord and agreed to by Tenant.

 If, on or before the date which is 180 days prior to the Expiration Date, Tenant has not agreed with Landlord’s
determination of the Market Rate and the rent escalations during the Extension Term after negotiating in good faith, Tenant may by written notice to Landlord not later than 180 days prior to the expiration of the Base Term of the Lease, elect
arbitration as described in Section 39(b) below. If Tenant does not elect such arbitration, Tenant shall be deemed to have waived any right to extend the Term of the Lease and the Extension Right shall terminate.” 

 

	9.	Removal of Tenant Improvements. Tenant shall not be required to remove any Tenant Improvements existing in the Original Premises or the Expansion Premises
as of the date of this Second Amendment or any Tenant Improvements constructed in the Original Premises or the Expansion Premises pursuant to the Work Letter at the expiration or earlier termination of the Term nor shall Tenant have the right to
remove any such Tenant Improvements at any time. If Tenant constructs any Tenant Improvements in the Expansion Premises prior to the Expansion Premises Commencement Date, Tenant shall obtain Achaogen’s consent to such Tenant Improvements
pursuant to the Achaogen Sublease and Landlord shall not charge any fee under the Achaogen Lease in connection with such Tenant Improvements. The Consent to Sublease shall provide that Achaogen shall not be required to remove any such Tenant
Improvements constructed in the Expansion Premises at the expiration or earlier termination of the Achaogen Lease nor shall Achaogen have the right to remove any such Tenant Improvements at any time. 

 

	10.	Landlord’s Furniture. During Tenant’s occupancy of the Expansion Premises under the Achaogen Sublease and during the Term of the Lease with
respect to the Expansion Premises, Tenant shall have the right to use in the Premises the furniture belonging to Landlord located within the Expansion Premises as of the date of this Second Amendment (“Landlord’s Furniture”).
If, any time after the date of this Second Amendment, Tenant does not want to use certain items of Landlord’s Furniture, Tenant shall notify Landlord in writing of such item(s) of Landlord Furniture that Tenant does not want to use and Landlord
shall inform Tenant whether Tenant may remove such item(s) of Landlord’s Furniture from the Premises and, if Landlord authorizes the removal of such item(s) of Landlord’s Furniture, any reasonable requirements, if any, of Landlord in
connection with Tenant’s removal from the Premises of such item(s) of Landlord’s Furniture. If Landlord does not authorize Tenant to remove such item(s), Landlord shall cause such item(s) to be removed, at Landlord’s sole cost, within
10 business days of Landlord receipt of Tenant’s written request for such removal by Landlord. 

  
 4 

 Except as otherwise set forth in this Second Amendment, (i) Tenant shall accept
Landlord’s furniture in its condition as of the date Tenant occupies the Expansion Premises pursuant to the Achaogen Sublease, (ii) Landlord shall have no obligation for any defects in Landlord’s Furniture, and
(iii) Tenant’s taking possession of the Expansion Premises under the Achaogen Sublease shall be conclusive evidence that Tenant accepts Landlord’s Furniture and that Landlord’s Furniture was in good condition at the time
possession was taken. Tenant agrees and acknowledges that, except as otherwise set forth in the Lease or this Second Amendment, neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of
Landlord’s Furniture. 
  

	11.	Signage. So long as Tenant leases at least 48,000 rentable square feet in the Building, Tenant shall have the right to display, at Tenant’s sole cost
and expense, Tenant’s name and logo in a location on the west wing of the Building in the location shown on Exhibit D hereto (“Building Sign”). For purposes of the preceding sentence, the Expansion Premises shall be
considered leased during the term of the Achaogen Sublease. Tenant further acknowledges and agrees that the Building Sign including, without limitation, the location, size, color and type, shall be subject to Landlord’s prior written approval,
which shall not be unreasonably withheld and shall be consistent with Landlord’s signage program at the Project and applicable Legal Requirements. Tenant shall be responsible, at Tenant’s sole cost and expense, for the maintenance of the
Building Sign, for the removal of the Building Sign at the expiration or earlier termination of this Lease and for the repair all damage resulting from such removal. 

 

	12.	Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively,
“Broker”), other than Cresa, in connection with the transaction reflected in this Second Amendment. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other
than the brokers, if any named in this Second Amendment, claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 

 

	13.	Provisions of Achaogen Lease as to Expansion Premises During Term of Achaogen Sublease. During the term of the Achaogen Sublease with respect to
the Expansion Premises only, Landlord shall: (a) not include in Operating Expenses thereunder any amounts that could not then be included in Operating Expenses under the Lease; and (b) not require Tenant to indemnify Landlord for any
Claims to the extent Tenant would not be required to indemnify Landlord for such Claims under Section 16 of the Lease. 

  

	14.	Miscellaneous. 

 a. This Second Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and
discussions. This Second Amendment may be amended only by an agreement in writing, signed by the parties hereto. 
 b.
This Second Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective successors and assigns. 
 c. This Second Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute one and the same instrument.
The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical thereto except having additional signature
pages executed by other parties to this Second Amendment attached thereto. 
 d. Except as amended and/or modified by this
Second Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect, 

  
 5 

 
unaltered and unchanged by this Second Amendment. In the event of any conflict between the provisions of this Second Amendment and the provisions of the Lease, the provisions of this Second
Amendment shall prevail. Whether or not specifically amended by this Second Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Second Amendment.

 e. The date applicable to the Expansion Premises in subpart (i) of the last sentence of Section 30(a) of the
Lease shall be the commencement date of the Achaogen Sublease. 

  
 6 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the
day and year first above written. 
  

							
	LANDLORD:	 	ARE-SAN FRANCISCO NO. 17, LLC,
		 	a Delaware limited liability company
			
		 	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
		 		 	 a Delaware limited partnership,
 managing member

				
		 		 	By:	 	ARE-QRS CORP., a Maryland corporation,
		 		 		 	general partner
				
		 		 		 	By: /s/ Eric S. Johnson
		 		 		 	Its: Vice President
		 		 		 	       Real Estate Legal Affairs
		
	TENANT:	 	FLUIDIGM CORPORATION,
		 	a Delaware corporation
			
		 	By:	 	/s/ Vikram Jog
		 	Its:	 	Chief Financial Officer

  
 7 

 EXHIBIT A 
 Expansion Premises 
  
 

 

 EXHIBIT B 
 Acknowledgment of Expansion Premises Commencement Date 
 This
ACKNOWLEDGMENT OF EXPANSION PREMISES COMMENCEMENT DATE is made this          day of                 ,
    , between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation (“Tenant”), and is attached to and
made a part of the Lease Agreement dated as of September 14, 2010, as amended by that First Amendment to Lease dated as of September 22, 2010, as further amended by that certain letter agreement dated August 2, 2012, and as further
amended by that certain Second Amendment to Lease dated as of                     , 2013 (as amended, the “Lease”), by and between
Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
 Landlord and Tenant hereby acknowledge and agree, for all purposes of the Lease, that the Expansion Premises Commencement Date is
                ,     , and the Expiration Date of the Lease shall be midnight on April 30, 2020. In case of a conflict between the terms of the
Lease and the terms of this Acknowledgment of Expansion Premises Commencement Date, this Acknowledgment of Expansion Premises Commencement Date shall control for all purposes. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this ACKNOWLEDGMENT OF EXPANSION PREMISES COMMENCEMENT DATE to be effective on the date first above written. 

 

									
	LANDLORD:	 	ARE-SAN FRANCISCO NO. 17, LLC,
		 	a Delaware limited liability company
			
		 	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
		 		 	 a Delaware limited partnership,
 managing member

				
		 		 	By:	 	 ARE-QRS CORP., a Maryland corporation,
 general partner

					
		 		 		 	By:	 	  

		 		 		 	Its:	 	  

		
	TENANT:	 	FLUIDIGM CORPORATION,
		 	a Delaware corporation
			
		 	By:	 	  

		 	Its:	 	  

 EXHIBIT C 
 Work Letter 
 THIS WORK LETTER (this “Work Letter”)
is incorporated into that certain Lease Agreement dated as of September 14, 2010, as amended by that First Amendment to Lease dated as of September 22, 2010, and as further amended by that certain Second Amendment to Lease of even date
herewith (as amended, the “Lease”), by and between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation
(“Tenant”). Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 
  

	 	1.	General Requirements. 

(a) Tenant’s Authorized Representative. Tenant designates Les Winchester (“Tenant’s Representative”) as
the only person authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication (“Communication”) from or on behalf of Tenant
in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord.

 (b) Landlord’s Authorized Representative. Landlord designates Todd Miller and Rob Kain (either such individual
acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other
Communication from or on behalf of Landlord in connection with this Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any time upon not less than 5
business days advance written notice to Tenant. 
 (c) Architects, Consultants and Contractors. Landlord and Tenant hereby
acknowledge and agree that the architect (the “TI Architect”) for the Tenant Improvements (as defined in Section 2(a) below), the general contractor and any subcontractors for the Tenant Improvements shall be selected by
Tenant, subject to Landlord’s approval, which approval shall not be unreasonably withheld, conditioned or delayed. Landlord shall be named a third party beneficiary of any contract entered into by Tenant with the TI Architect, any consultant,
any contractor or any subcontractor, and of any warranty made by any contractor or any subcontractor. Landlord hereby approves of DGA as Tenant’s architect and Landmark as Tenant’s general contractor. 

 

	 	2.	Tenant Improvements. 

 (a)
Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the Premises (including the Expansion Premises) desired by Tenant of a fixed and permanent nature. Other than funding the TI
Allowance (as defined below) as provided herein, Landlord shall not have any obligation whatsoever with respect to the finishing of the Premises for Tenant’s use and occupancy. 

(b) Tenant’s Space Plans. Tenant shall be responsible for the delivery to Landlord of schematic drawings and outline
specifications (the “TI Design Drawings”) detailing Tenant’s requirements for the Tenant Improvements. Not more than 10 days thereafter, Landlord shall deliver to Tenant the written objections, questions or comments of Landlord
and the TI Architect with regard to the TI Design Drawings. Tenant shall cause the TI Design Drawings to be revised to address such written comments and shall resubmit said drawings to Landlord for approval within 10 days thereafter. Such process
shall continue until Landlord has approved the TI Design Drawings. Landlord approves of the Tenant Improvements described on Schedule 1 of this Work Letter and shall not unreasonably withhold its consent to the TI Design Drawings to the
extent consistent therewith. 

  
 C-1

 (c) Working Drawings. Not later than 15 business days following the approval of the
TI Design Drawings by Landlord, Tenant shall cause the TI Architect to prepare and deliver to Landlord for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”),
which TI Construction Drawings shall be prepared substantially in accordance with the TI Design Drawings. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant
Improvements. Landlord shall deliver its written comments on the TI Construction Drawings to Tenant not later than 10 business days after Landlord’s receipt of the same; provided, however, that Landlord may not disapprove any matter that is
consistent with the TI Design Drawings. Tenant and the TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Landlord how Tenant proposes to respond to such comments. Any disputes in
connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the TI Design Drawings or otherwise reasonably acceptable to
Landlord, Landlord shall approve the TI Construction Drawings submitted by Tenant. Once approved by Landlord, subject to the provisions of Section 4 below, Tenant shall not materially modify the TI Construction Drawings except as may be
reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(a) below). 
 (d)
Approval and Completion. If any dispute regarding the design of the Tenant Improvements is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding
the design of the Tenant Improvements, provided (i) Tenant acts reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all
costs and expenses resulting from any such decision by Tenant shall be payable out of the TI Allowance (as defined in Section 5(b) below) or otherwise payable by Tenant, and (iii) Tenant’s decision will not affect the base
Building, structural components of the Building or any Building systems (in which case Landlord shall make the final decision). Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same requested by
Tenant shall be processed as provided in Section 4 hereof. 
 (e) No Obligation to Building Tenant
Improvements. Notwithstanding anything to the contrary contained in this Work Letter, Tenant’s failure to design or construct the Tenant Improvements or meet any of the time periods set forth in this Work Letter for the construction of the
Tenant Improvements shall not be a default under the Lease. Nothing contained in this Work Letter shall delay the Expansion Premises Commencement Date or the Expansion Premises Rent Commencement Date. 

 

	 	3.	Performance of the Tenant Improvements. 

 (a) Commencement and Permitting of the Tenant Improvements. Tenant shall commence construction of the Tenant Improvements upon obtaining and delivering to Landlord a building permit (the
“TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Landlord. The cost of obtaining the TI Permit shall be payable from the TI Allowance. Landlord shall
assist Tenant in obtaining the TI Permit. Prior to the commencement of the Tenant Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s contractors (including the TI Architect), and certificates of insurance from
any contractor performing any part of the Tenant Improvement evidencing industry standard commercial general liability, automotive liability, “builder’s risk”, and workers’ compensation insurance. Tenant shall cause the general
contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the general contractor’s liability coverages required above. 

(b) Selection of Materials, Etc. Where more than one type of material or structure is indicated on the TI Construction Drawings
approved by Tenant and Landlord, the option will be within Tenant’s reasonable discretion if the matter concerns the Tenant Improvements, and within Landlord’s sole and absolute subjective discretion if the matter concerns the structural
components of the Building or any Building System. 

  
 C-2

 (c) Tenant Liability. Tenant shall be responsible for correcting any deficiencies or
defects in the Tenant Improvements. 
 (d) Substantial Completion. Tenant shall substantially complete or cause to be
substantially completed the Tenant Improvements in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a non-material nature which do not interfere
with the use of the Premises (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of the Tenant Improvements, Tenant shall require the TI Architect and the general contractor to
execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Work Letter, “Minor
Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI Permit); (ii) to comport with good design,
engineering, and construction practices which are not material; or (iii) to make reasonable adjustments for field deviations or conditions encountered during the construction of the Tenant Improvements. 

4. Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by Landlord of the TI
Design Drawings, shall be requested and instituted in accordance with the provisions of this Section 4 and shall be subject to the written approval of Landlord, which approval shall not be unreasonably withheld, conditioned or delayed.

 (a) Tenant’s Right to Request Changes. If Tenant shall request changes (“Changes”), Tenant shall
request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such Change
Request must be signed by Tenant’s Representative. Landlord shall review and approve or disapprove such Change Request within 10 business days thereafter, provided that Landlord’s approval shall not be unreasonably withheld, conditioned or
delayed. 
 (b) Implementation of Changes. If Landlord approves such Change, Tenant may cause the approved Change to be
instituted. If any TI Permit modification or change is required as a result of such Change, Tenant shall promptly provide Landlord with a copy of such TI Permit modification or change. 

 

	 	5.	Costs. 

 (a) Budget For
Tenant Improvements. Before the commencement of construction of the Tenant Improvements, Tenant shall obtain a detailed breakdown, by trade, of the costs incurred or that will be incurred, in connection with the design and construction of The
Tenant Improvements (the “Budget”), and deliver a copy of the Budget to Landlord for Landlord’s approval, which shall not be unreasonably withheld or delayed. The Budget shall be based upon the TI Construction Drawings approved
by Landlord and shall include a payment to Landlord of administrative rent (“Administrative Rent”) equal to 1% of the TI Costs (as hereinafter defined) for monitoring and inspecting the construction of the Tenant Improvements, which
sum shall be payable from the TI Allowance. Such Administrative Rent shall include, without limitation, all out-of-pocket costs, expenses and fees incurred by or on behalf of Landlord arising from, out of, or in connection with, such monitoring of
the construction of the Tenant Improvements, and shall be payable out of the TI Allowance. 
 (b) TI Allowance. Landlord
shall provide to Tenant a tenant improvement allowance (collectively, the “TI Allowance”) as follows: 
 1. a
“Tenant Improvement Allowance” in the maximum amount of $15.00 per rentable square foot in the Premises (including the Expansion Premises), or $726,075 in the aggregate, which is included in the Base Rent set forth in the Lease; and

  
 C-3

 2. an “Additional Tenant Improvement Allowance” in the maximum amount of
$10.00 per rentable square foot in the Premises (including the Expansion Premises, or $484,050 in the aggregate, which shall, to the extent used, result in TI Rent as set forth in the Second Amendment. 

The TI Allowance shall be disbursed in accordance with this Work Letter. Tenant shall have no right to the use or benefit (except as
provided below with respect to the Tenant Improvement Allowance) of any portion of the TI Allowance not required for the construction of (i) the Tenant Improvements described in the TI Construction Drawings approved pursuant to
Section 2(d) or (ii) any Changes pursuant to Section 4. Except as provided in the immediately following sentence, Tenant shall have no right to any portion of the TI Allowance that is not disbursed before the last day of
the month that is 12 months after the Expansion Premises Commencement Date. Following such 12 month period, any portion of the Tenant Improvement Allowance remaining unused shall be applied to Base Rent coming due in the immediately following 6
month period pursuant to a schedule reasonably acceptable to Landlord and Tenant until such unused portion of the Tenant Improvement Allowance has been exhausted. 
 (c) Costs Includable in TI Allowance. The TI Allowance shall be used solely for the payment of design, permits and construction costs in connection with the construction of the Tenant
Improvements, including, without limitation, the cost of electrical power and other utilities used in connection with the construction of the Tenant Improvements, the cost of preparing the TI Design Drawings and the TI Construction Drawings, all
costs set forth in the Budget, including Landlord’s Administrative Rent, and the cost of Changes (collectively, “TI Costs”). Notwithstanding anything to the contrary contained herein, the TI Allowance shall not be used
to purchase any furniture, personal property or other non-Building system materials or equipment, including, but not be limited to, Tenant’s voice or data cabling, non-ducted biological safety cabinets and other scientific equipment not
incorporated into the Tenant Improvements. 
 (d) Excess TI Costs. Landlord shall have no obligation to bear any portion
of the cost of any of the Tenant Improvements except to the extent of the TI Allowance. If at any time and from time-to-time, the remaining TI Costs under the Budget exceed the remaining unexpended TI Allowance (the “Excess TI
Costs”), Tenant shall directly pay, without any right to reimbursement from Landlord, any necessary funds to cover such Excess TI Costs, and Tenant shall deliver evidence of such payment to Landlord, before any initial or further TI
Allowance is utilized for the Tenant Improvements. Notwithstanding anything to the contrary set forth in this Section 5(d), Tenant shall be fully and solely liable for TI Costs and the cost of Minor Variations in excess of the TI
Allowance. 
 (e) Payment for TI Costs. During the course of design and construction of the Tenant Improvements, Landlord
shall reimburse Tenant for TI Costs once a month against a draw request in Landlord’s standard form, containing evidence of payment of such TI Costs by Tenant and such certifications, lien waivers (including a conditional lien release for each
progress payment and unconditional lien releases for the prior month’s progress payments), inspection reports and other matters as Landlord customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30
days following receipt of such draw request. Upon completion of the Tenant Improvements (and prior to any final disbursement of the TI Allowance), Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors
and first tier subcontractors who did the work and final, unconditional lien waivers from all such contractors and first tier subcontractors; (ii) as-built plans (one copy in print format and two copies in electronic CAD format) for such Tenant
Improvements; (iii) a certification of substantial completion in Form AIA G704, (iv) a certificate of occupancy for the Premises; and (v) copies of all operation and maintenance manuals and warranties affecting the Premises.
Notwithstanding anything to the contrary contained herein, Tenant shall at all times have not less than a 10% retainage with respect to its general contractor for the Tenant Improvements and as a condition to payment of any draw requests Landlord
shall be entitled to confirm that the percentage of work completed is consistent with the percentage of payment then being sought. 

  
 C-4

	 	6.	Miscellaneous. 

 (a)
Consents. Whenever consent or approval of either party is required under this Work Letter, that party shall not unreasonably withhold, condition or delay such consent or approval, except as may be expressly set forth herein to the contrary.

 (b) Modification. No modification, waiver or amendment of this Work Letter or of any of its conditions or provisions
shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 
 (c) Tenant Improvements. The
construction by Tenant of the Tenant Improvements shall be governed by this Work Letter and the provisions of Section 12 of the Lease shall not apply thereto. 

  
 C-5

 Schedule 1 
 Description of Tenant Improvements 
 Suite 100 

 

	 	•	 	 Note 1: Add a wall mounted pass through in room 204A. (TBD) 

 

	 	•	 	 Note 2: Add door between room 205A and 207. (TBD) 

  

	 	•	 	 Note 3: Remove door and wall off. (TBD) 

  

	 	•	 	 Note 4: Add sink, sink will be relocated from room 211. (TBD) 

 

	 	•	 	 Note 5: Add new ceiling grid and lights in training room 201. Add power and data outlets in multiple locations in floor. (TBD)

  

	 	•	 	 Add power and data to conference room floors. (TBD) 

  

	 	•	 	 Add or relocate 3 card readers on the first floor. 

 Suite 371 
  

	 	•	 	 Note 1: Remove door and wall off. (at move in) 

  

	 	•	 	 Note 2: Remove sprinkler system in room 359 and demo walls (at move in) 

 

	 	•	 	 Note 3: Remove small offices and replace with cubicles. 

 

	 	•	 	 Note 4: Build additional lab space by removing (2) offices, (1) file storage, (1) conference room. 

 

	 	•	 	 Note 5: Add new egress door for Achaogen using door from note 1. Door will open into alcove in front of service elevator. 

 

	 	•	 	 Add or relocate 2 card readers on the third floor. 

 (continued on next page) 

  
 C-6

  
 

 
  

  
 C-7

 EXHIBIT D 
 Signage Location

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00217-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00217-of-00352.parquet"}]]