Document:

Exhibit 10.11.2

SECOND
AMENDMENT OF LEASES

This Second
Amendment of Leases (this “Amendment”) is made as of this 25th day of July, 2005 by and between One Kendall
Square Associates, LLC (“Landlord”) and Genzyme Corporation (“Tenant”).

1.             BACKGROUND

Reference is made to the
following:

1.1           Amendment of Leases:  An Amendment of Leases dated December 17,
2004 by and between Landlord and Tenant (“Amendment of Leases”).  The Amendment of Leases amends two leases
(collectively “Leases”) between the parties, one of the Leases (“Building 600
Lease”) relating to premises located in Building 600/650/700 (“Building 600”),
One Kendall Square, Cambridge, Massachusetts, and the other of the Leases (“Building
1400 Lease”) relating to premises located in Building 1400 (“Building 1400”),
One Kendall Square, Cambridge, Massachusetts. 
Any capitalized terms used in this Second Amendment of Leases shall have
the same definitions as set forth in the Amendment of Leases, except to the
extent otherwise expressly set forth herein.

1.2           Premises A:  Premises A consists of the Building 600
Premises, as defined in the Amendment of Leases, and Suite 501 located on the
fifth (5th)
floor of Building 1400, as defined in the Amendment of Leases.   The terms of the Leases in respect of Premises
A and Suite 501 expire as of December 24, 2006, unless Tenant exercises its
option to extend the term thereof in accordance with the Amendment of Leases.

1.3           Premises
B:  Premises B consists of
portions of the lower level, the second (2nd) floor, the third (3rd) floor and the fourth (4th) floor of Building 1400, all as more
particularly defined in the Amendment of Leases.  For the purposes of this Second Amendment of
Leases, the Premises B defined in the Amendment of Leases are hereinafter
referred to as “Existing Premises B”. 
The term of the Building 1400 Lease in respect of  Existing Premises B expires as of December
24, 2006, unless Tenant exercises its option to extend the term thereof in
accordance with the Amendment of Leases.

1.4           Premises C:  Premises C consists of portions of the first
(1st),
second (2nd), third (3rd), fourth (4th), and fifth (5th) floors of Building 1400, all as more
particularly defined in the Amendment of Leases.  The term of the Building 1400 Lease in
respect of Premises C expires as of July 24, 2005.

1.5           Extended Term Portions of
Premises C: 
Notwithstanding the fact that the term of the Building 1400 Lease in
respect of Premises C expires as of July 24, 2005, Tenant desires to extend the
term of the Building 1400 Lease in respect of the following portions (“Extended
Term Portions of Premises C”) for an additional period commencing as of July
25, 2005 and expiring as of December 24, 2006:

 1
 

 

·                  An
area on the second (2nd)
floor of Building 1400, containing 3,605 rentable square feet, substantially as
shown on Exhibit A, Sheet 1 attached hereto

·                  An
area on the fourth (4th)
floor of Building 1400, containing 669 rentable square feet, substantially as
shown on Exhibit A, Sheet 2 attached hereto

·                  An
area on the second (5th)
floor of Building 1400, containing 74 rentable square feet, substantially as
shown on Exhibit A, Sheet 3 attached hereto.

1.6           Deleted Portion of
Premises B: 
Notwithstanding the fact that the term of the Building 1400 Lease in
respect of Premises B was, pursuant to the Amendment of Leases, extended for a
period commencing as of July 25, 2005 and expiring as of December 24, 2006,
Tenant desires to terminate the term of the Building 1400 Lease in respect of
the portion (“Deleted Portion of Premises B”) containing 3,605 rentable square
feet and shown on Exhibit A, Sheet 2 effective as of July 24, 2005.

NOW THEREFORE, for
good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties hereby agree that the Building 1400 Lease, as
previously amended, is hereby further amended as follows:

2.             EXTENSION OF TERM OF
BUILDING 1400 LEASE IN RESPECT OF THE EXTENDED TERM PORTIONS OF PREMISES C

The term of the
Building 1400 Lease in respect of the Extended  Term
Portions of Premises C are hereby extended for an additional term commencing as
of July 25, 2005 and ending as of December 24, 2006.  The demise of the Extended Term Portions of
Premises C shall be upon all of the same terms and conditions of the Building
1400 Lease applicable to Premises B.  The
Extended Term Portions of Premises C are hereby incorporated into and made a
part of Premises B, and Tenant shall have the same rights and obligations with
respect to the Extended Term Portions of Premises C as Tenant has with respect
to Premises B, including but not limited to, extension options, termination
right and rights of first refusal.  The
Base Rent payable in respect of the Extended Portions of Premises C is included
in the Base Rent payable in respect of Premises B, as set forth in Section 4
below.  Except as provided herein, the
Building 1400 Lease in respect of Premises C terminated as of July 24, 2005.

3.             TERMINATION OF TERM OF
BUILDING 1400 LEASE IN RESPECT OF DELETED PORTION OF PREMISES B

The Building 1400
Lease in respect of the Deleted Portion of Premises B is hereby terminated
effective as of July 24, 2005.  Annual
Base Rent and other charges payable in respect of the Deleted Portion of
Premises B shall be apportioned as of July 24, 2005.

4.             REVISED DEFINITION OF
PREMISES B

4.1           Definition.  Giving effect to the extension of the term of
the Building 1400 Lease in respect of the Extended Term Portions of Premises C,
the termination of 

 2
 

the Building 1400 Lease in respect of the Deleted
Portion of Premises B, and the incorporation of the Extended Term Portions of
Premises C into Premises B, the parties hereby agree that, for all purposes
under the Leases and Amendment of Leases, Tenant has the right to use 39
parking spaces, and Premises B shall consist of areas containing 37,435 rentable
square feet, as follows:

(1)           A
portion of the lower level of Building 1400, containing 3,869 square feet of
space, as shown on Exhibit B-2, Sheet 1 attached to the Amendment of Leases.

(2)           A portion of the second (2nd) floor of Building 1400, containing
14,219 square feet of space, as shown on Exhibit A, Sheet 1 attached to this
Second Amendment of Leases.

(3)           A portion of the third (3rd) floor of Building 1400,
containing 18,604 square feet of space, as shown on Exhibit B-2, Sheet 5
attached to this Second Amendment of Leases.

(4)           A portion of the fourth (4th) floor of Building 1400,
containing 669 square feet of space, as shown on Exhibit A, Sheet 2 attached to
this Second Amendment of Leases.

(5)           A portion of the fifth (5th) floor of Building 1400
containing 74 square feet of space, as shown on Exhibit A, Sheet 3 attached to
this Second Amendment of Leases.

4.2           Annual Base Rent.  During the period commencing as of July 25,
2005 and expiring as of December 24, 2006, the annual Base Rent in respect of
Premises B (as defined in this Section 4 shall be Nine Hundred Thirty-Five
Thousand Eight Hundred Seventy-Five and 00/100 ($935,875.00) Dollars (i.e., a
monthly payment of $77,989.58).

5.                                       Tenant’s Proportionate CAO Lot Share and Tenant’s
Proportionate Building Share

For purposes of determining Tenant’s Proportionate CAO
Lot Share and Tenant’s Proportionate Building Shares the parties hereby confirm
and agree that the square footage of space included in the Complex and each of
the Buildings is as follows:

	
  

  	
  Building 600:

  	
  224,803 square feet

  
	
   

  	
  Building 1400:

  	
  133,077 square feet

  
	
   

  	
  Complex:

  	
  650,681 square feet

  

 

 3
 

 

As
herein amended, the Leases are ratified, approved and confirmed in all
respects.

EXECUTED under seal as of the date first above written.

	
  LANDLORD:

  	
  TENANT:

  
	
  ONE KENDALL
  SQUARE

  	
  GENZYME CORPORATION, a

  
	
  ASSOCIATES, LLC,

  	
  Massachusetts Corporation

  
	
  a Delaware
  limited liability company

  	
   

  

 

By:                              One
Kendall Square

Mezzanine, LLC,

its sole member

By:                              One
Kendall Square Investors, LLC

its sole member

By:                              Lincoln-One
Kendall Square, LLC

its administrative member

	
  By: 

  	
  /s/ W. Frank
  Cofer

  	
   

  	
  By: 

  	
  /s/ Michael S. Wyzga

  
	
   

  	
  Name:  W. Frank Cofer

  	
   

  	
   

  	
  Name:  Michael
  S. Wyzga

  
	
   

  	
  Title:  Vice President

  	
   

  	
   

  	
  Title:  Chief
  Financial Officer

  
	
   

  	
  Hereunto Duly
  Authorized

  	
   

  	
   

  	
  Hereunto Duly Authorized

  
	
   

  	
   

  
	
  Date Signed:

  	
  12/28/05

  	
   

  	
  Date Signed: 

  	
  12/20/05

  
							

 

 4
 

 

SECOND AMENDMENT
OF LEASES

EXHIBIT A, SHEET 1

SECOND FLOOR

(EXISTING PREMISES B AND

EXTENDED TERM PORTION OF PREMISES C)

 5
 

 

SECOND AMENDMENT
OF LEASES

EXHIBIT A, SHEET 2

FOURTH FLOOR

(EXTENDED TERM PORTION OF EXHIBIT C

AND

DELETED PORTION OF PREMISES B

 6
 

 

SECOND AMENDMENT
OF LEASES

EXHIBIT A, SHEET 3

FIFTH FLOOR

EXTENDED TERM PORTION OF PREMISES C

 

 7Exhibit
10.11.3

THIRD
AMENDMENT OF LEASES

THIS THIRD
AMENDMENT OF LEASES (the “Third Amendment”) is made this 4th day of January, 2007, by and between RB KENDALL FEE, LLC (“Landlord”) and GENZYME CORPORATION, having a mailing
address at 500 Kendall Street, Cambridge, Massachusetts 02139 (“Tenant”).

R
E  C  I  T  A  L  S:

Reference is made
to the following:

A.            One Kendall Realty Trust,
predecessor-in-interest to Landlord, and Tenant entered into those certain
leases (collectively, the “Leases”) described in the Amendment of Leases, dated
December 17, 2004, between Landlord’s predecessor-in-interest and Tenant (the “First
Amendment”) and the Second Amendment of Leases, dated July 25, 2005 (the “Second
Amendment”), by and between Landlord’s predecessor in title and Tenant  (collectively, the “Amendments”).  One of the Leases (the “Building 600 Lease”)
relates to premises located in Building 600/650/700  (“Building 600”), One Kendall Square,
Cambridge, Massachusetts (the “Complex”) and the other Lease relates to premises
located in Building 1400 (the “Building 1400 Lease”) in the Complex.  Capitalized terms used but not defined herein
shall have the same meaning as in the Lease or Amendments.

B.            Landlord and Tenant are the current
holders, respectively, of the lessor’s and lessee’s interests in the Lease.

C.            The term of the Leases with respect
to Premises A and Premises B (all as defined in the Second Amendment), as
extended in accordance with the terms of the First Amendment by notices from
Tenant to Landlord dated May 31, 2006 and September 22, 2006, is set to expire
on June 24, 2007.

D.            Landlord and Tenant want to extend
the term of the Leases with respect to certain portions of the demised
premises, confirm the annual Base Rent payable during such extended term and
further revise the Leases as set forth in this Third Amendment.

E.             Landlord and Tenant now desire to
amend the Leases as set forth herein.

A
G  R  E  E  M  E  N  T  S:

NOW, THEREFORE, in
consideration of the mutual covenants and agreements herein contained, and for
other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, Landlord and Tenant hereby agree to amend the Leases as
follows:

1.             Premises B.  The term of the Building 1400 Lease with
respect to Premises B, which contains 37,435 square feet, is hereby extended
for an additional term commencing June 25, 2007 and expiring on February 28,
2008 (the “Premises B Extended Term”). 
From the date hereof until the expiration of the Premises B Extended
Term, the annual Base Rent in respect of Premises B shall be $935,875.00,
payable in monthly amounts of $77,989.58 in accordance with the terms of the
Building 1400 Lease.

 

2.             Revised Definition of Premises A.  The parties agrees that, for all purposes
under this Third Amendment, the demised premises comprising Premises A (as
defined in the Amendments) shall be redefined as follows:

                “Premises A 2007” shall consist
of a portion of the premises currently demised under the Building 600 Lease and
the Building 1400 Lease, as amended by the Amendments, containing, in the
aggregate, 84,280 rentable square feet, as shown on Exhibit A, Sheets 1, 2 and
3, attached hereto, as follows:

a)                                         A
portion of the lower level of Building 600 containing 4,914 square feet of
space;

b)                                        A
portion of the fourth (4th) and
fifth (5th) floors
(including a portion of the fourth (4th)
floor mezzanine) of Building 600 containing 62,810 square feet of space; and 

c)                                         A
portion of the fifth (5th)
floor of Building 1400 containing 16,556 square feet of space.

 

“Premises
A 2008” shall consist of a portion of the premises currently demised under the
Building 600 Lease, as amended by the Amendments, containing, in the aggregate,
36,036 rentable square feet in Building 600, as shown on Exhibit B, Sheets 1, 2
and 3 attached hereto as follows:

a)                                         A
portion of the fourth (4th)
floor containing 25,324 square feet of space;

b)                                        A
portion of the fourth (4th)
floor containing 4,441 square feet of space;

c)                                         A
portion of the fourth (4th)
floor mezzanine containing 1,841 square feet of space;

d)                                        A
portion of the fifth (5th)
floor containing 4,329 square feet of space;

e)                                         A
portion of the fifth (5th)
floor containing 101 square feet of space; and

f)                                           The
Security & IT Closets as shown on Sheet 3 of Exhibit B.

 

3.             Premises A 2007.  The term of the Leases with respect to
Premises A 2007 is hereby extended for an additional term commencing June 25,
2007 and expiring on September 30, 2007.   
During the period commencing on the date hereof and expiring on March
24, 2007, the annual Base Rent in respect of Premises A 2007 shall be
$2,528,400.00, payable in monthly amounts of $210,700.00.  During the period commencing March 25, 2007
and expiring September 30, 2007, the annual Base Rent in respect of Premises
2007 A shall be $2,633,750.00, payable in monthly amounts of $219,479.16.

4.             Premises A 2008.  The term of the Building 600 Lease with
respect to Premises A 2008 is hereby extended for an additional term commencing
June 25, 2007 and expiring on February 28, 2008.  During the period commencing on the date
hereof and expiring on March 24, 2007, the annual Base Rent in respect of
Premises A 2008 shall be $1,081,080.00, payable in monthly amounts of
$90,090.00.  During the period commencing
March 25, 2007 and expiring February 28, 2008, the annual Base Rent in respect
of Premises A 2008 shall be $1,126,125.00, payable in monthly amounts of
$93,843.75.

5.             No Further Extension Rights or
Rights of First Refusal.  Tenant
acknowledges and agrees that it shall have no further right to extend the term
of the Leases beyond the dates set forth in this Third Amendment and no rights
of first refusal on any space within the Complex.  Without limiting the foregoing, Sections 2.2,
3.2 and 3.3 of the First Amendment shall be void and without further force or
effect.

6.             Tenant’s Proportionate Shares.  Throughout the term of the Leases, as
extended herein, Tenant shall continue to pay Lessee’s Proportionate CAO Lot
Share, Lessee’s Proportionate Building Share and Tenant’s pro rata share of
real estate taxes, with the calculation of said payment being adjusted 

 2
 

to reflect any decrease
in rentable square footage leased by Tenant as Tenant surrenders space in
accordance with the provisions of this Third Amendment.  After the Tenant surrenders Premises A 2007
to Landlord in accordance with the terms of the Building 600 Lease, Building
1400 Lease, Amendments and this Third Amendment, the Lessee’s Proportionate CAO
Lot Share under the Building 600 Lease shall be 5.54%, Lessee’s Proportionate
Building Share under the Building 600 Lease shall be 16.03%, Lessee’s
Proportionate CAO Lot Share under the Building 1400 Lease shall be 5.75%,
Lessee’s Proportionate Building Share under the Building 1400 Lease shall be
28.13% and Tenant’s pro rata share of real estate taxes under each of the
Leases shall be the same percentages as set forth above.

7.             Utilities.  Tenant’s obligation to pay for utilities, as
set forth in the Leases, shall continue throughout the term with any pro rata
payments being adjusted to reflect any decrease in rentable square footage
leased by Tenant as Tenant surrenders space in accordance with the provisions
of this Third Amendment.  The parties
acknowledge that Landlord is unaware of the specifics of how electrical service
is distributed by the utility company to the various premises leased by
Tenant.  Tenant agrees, however, that if
the entirety of Premises A 2007 is not separately metered from Premises B and
Premises A 2008, then after expiration of the term for Premises A 2007, and no
later than October 31, 2007, Tenant shall, at Tenant’s sole cost and expense,
furnish and install any necessary metering equipment to measure the consumption
of electric current in Premises A 2007 separately from Premises B and Premises
A 2008.  If Landlord elects to take back
the Surrendered Space (as defined below), then Tenant shall, at Tenant’s sole
cost and expense and within thirty (30) days after the Surrender Date (as
defined below) (or such longer period as is reasonably necessary to complete
the hereinafter described work, provided that Tenant has commenced and is
diligently pursuing the completion of such work and; further provided, that
such period shall not extend beyond ninety (90) days after the Surrender Date)
furnish and install any necessary metering equipment to measure the consumption
of electric current in the Surrendered Space separately from the remaining
portion of Premises A 2007 occupied by Tenant and separately from Premises B
and Premises A 2008.

8.             No Interior Cleaning Service.  Landlord and Tenant acknowledge and agree
that Landlord does not provide, and is not obligated to provide, any interior
cleaning services for the Premises B, Premises A 2007 or Premises A 2008.  Landlord shall not charge Tenant for any
interior cleaning services and such charges shall not be included in Lessee’s
Proportionate CAO Lot Share or Lessee’s Proportionate Building.

9.             Take Back Option.  Commencing January 1, 2007, Landlord has the
option, exercisable on thirty (30) days prior written notice to Tenant, to take
back the portion of Premises A 2007 consisting of 16,556 rentable square feet
on the fifth (5th)
floor of Building 1400 as shown on Exhibit A, Sheet 3 (the “Surrendered Space”).  Landlord’s notice shall set forth the date by
which Tenant must yield up the Surrendered Space to Landlord in the condition
required under the Leases, Amendments and this Third Amendment (the “Surrender
Date”).  In no event shall the Surrender
Date be earlier than thirty (30) days after the date of Landlord’s notice.  If Tenant needs additional time to
decommission the Surrendered Space, as required under this Third
Amendment,  Tenant may extend the
Surrender Date on a day-to day basis in order to complete its decommissioning
work provided Tenant has commenced such work prior to the original Surrender
Date and is working diligently to complete such work.  As of the Surrender Date, Lessee’s
Proportionate CAO Lot Share under the Building 600 Lease shall be 15.95%,
Lessee’s Proportionate Building Share under the Building 600 Lease shall be 46.16%,
Lessee’s Proportionate CAO Lot Share under the Building 1400 Lease shall be
5.75%, Lessee’s Proportionate Building Share under the Building 1400 Lease
shall be 28.13% and Tenant’s pro rata share of real estate taxes under each of
the Leases shall be the same percentages as set forth above.  As of the Surrender Date, the Leases shall
automatically terminate with respect only to the Surrendered Space as if the
Leases had expired by its 

 3
 

terms with respect to the
Surrendered Space and Tenant shall be automatically relieved from all further
obligations with respect to the Surrendered Space as of the Surrender Date,
except as to those obligations in the Leases that expressly survive
termination.

10.           Parking.  Throughout the term of the Leases, the
Landlord will make available to Tenant one monthly parking pass for each 1,000
rentable square feet of space currently leased by Tenant pursuant to the Leases
for use in the One Kendall Square Garage (the “Garage”).  As of the date hereof, Tenant shall have the
right to use 158 parking spaces in the Garage based on the square footage for
Premises B, Premises A 2007 and Premises A 2008.  Tenant shall have no right to sublet, assign,
or otherwise transfer said parking passes except in connection with an
assignment of the Leases or sublease of the premises permitted pursuant to the
provisions of the Leases.  Said parking
passes shall be paid for by Tenant at the then current prevailing rate in the
Garage, as such rate may vary from time to time.  The current rate for such passes, as of the
date of this Third Amendment, is $200.00 per month.  If, for any reason, Tenant shall fail timely
to pay the charge for said parking passes, Landlord shall have the same rights
against Tenant as Landlord has with respect to the timely payment of Base Rent
hereunder.  Said parking passes will be
on an unassigned, non-reserved basis, and shall be subject to reasonable rules
and regulations from time to time in force. 
Tenant shall have the right, from time to time, upon at least thirty (30)
days prior written notice to Landlord, to surrender one or more of such parking
passes, and upon such surrender, Tenant shall have no further rights or
obligations with respect to such surrendered passes.  As Tenant surrenders portions of the demised premises
in accordance with this Third Amendment, Tenant shall also surrender the
corresponding parking passes.   During
the term of the Leases Landlord agrees to notify Tenant when additional parking
spaces become available in the Garage and Tenant shall have the option to
utilize such spaces on a month-to-month basis at the then current prevailing
rate in the Garage.  The provisions of
this Paragraph 10 shall replace all others in the Leases relating to parking
spaces in the Garage.

11.           Removal of Signage.  Upon execution of this Third Amendment,
Tenant shall commence, at its sole cost and expense,  the removal of any of its signage, if any,
from the front entrance, glass awning entrance and the clock tower on Building
1400.  At the expiration of the term of
the Leases, Tenant shall remove, at its sole cost and expense, all of its
exterior signage, if any, from Building 600. 
The removal of such signage shall not damage the premises or Building
1400 or Building 600, as the case may be, and the cost of repairing any damage
to the premises or said buildings arising from such removal shall be paid by
Tenant.

12.           Decommissioning of Premises.  On or before the date of the expiration of
the term for Premises B, Premises A 2007 or Premises A 2008 or the Surrender Date
if Landlord exercises its termination option in Paragraph 9 of this Third
Amendment, Tenant shall:

a)             Cause those portions of Premises B,
Premises A 2007, Premises A 2008 or the Surrendered Space, as the case may be,
used for laboratory purposes to be decommissioned in accordance with the
regulations of the U.S. Nuclear Regulatory Commission and/or the Massachusetts
Department of Public Health for the control of radiation, cause such premises
to be released for unrestricted use by the Radiation Control Program of the
Massachusetts Department of Public Health for the control of radiation, and
deliver to Landlord the report of a certified industrial hygienist or a
certified health physicist, as the case may be, stating that he or she has
examined such premises (including visual inspection, Geiger counter evaluation
and airborne and surface monitoring) and found no evidence that such portion of
such premises contains Hazardous Materials, as defined in this Third Amendment,
or is otherwise in violation of any Environmental Law, as also defined in this
Third Amendment hereof.

 4
 

 

b)            Provide to Landlord a copy of its
most current chemical waste removal manifest and a certification from Tenant
executed by an officer of Tenant that to the knowledge of such officer, after
due investigation, no Hazardous Materials or other potentially dangerous or
harmful chemicals brought onto such premises from and after the date that
Tenant first took occupancy of the premises remain in such premises.

13.           Defined Terms.  As used herein the term “Environmental Law”
means collectively all laws, statutes, ordinances, rules and regulations of any
local, state or federal governmental authority having jurisdiction concerning
environmental, health and safety matters, including, but not limited to, any
discharge into the air, surface, water, sewers, soil or groundwater of any
Hazardous Materials.  As used herein, the
term “Hazardous Materials” means any hazardous or toxic substance, material or
waste or petroleum derivative which is or becomes regulated by any
Environmental Law, specifically including live organisms, viruses and fungi,
medical waste, and so-called “biohazard” materials.  The term “Hazardous Materials” includes,
without limitation, any material or substance which is (i) designated as a “hazardous
substance” pursuant to Section 1311 of the Federal Water Pollution Control Act
(33 U.S.C. Section 1317), (ii) defined as a “hazardous waste” pursuant to
Section 1004 of the Federal Resource Conservation and Recovery Act, 42 U.S.C.
Section 6901 et seq. (42 U.S.C. Section 6903), (iii) defined as a “hazardous
substance” pursuant to Section 101 of the Comprehensive Environmental Response,
Compensation and Liability Act, 42 U.S.C. Section 9601 et seq. (42 U.S.C.
Section 9601), (iv) defined as “hazardous substance” or “oil” under Chapter 21E
of the General Laws of Massachusetts, or (v) a so-called “biohazard” or medical
waste, or is contaminated with blood or other bodily fluids; and “Environmental
Law” includes, without limitation, the laws listed in the preceding clauses (i)
through (iv).

14.           Systems.  Upon the expiration of the term of the
Leases, Tenant shall ensure that all mechanical systems remaining in Premises
B, Premises A 2007 and Premises A 2008, including, without limitation, Tenant’s
emergency medical and fire systems shall be in good, working order, normal wear
and tear excepted as of such premises’ respective term expiration dates..

15.           Segregation of Premises.  In the event Landlord leases any portion of
Premises A 2007 after such premises are vacated by Tenant, Tenant and Landlord
shall cooperate (a) in separating the vacated premises from the remaining
premises still occupied by Tenant with separate demising walls; (b) in ensuring
that the tenants leasing such premises have all necessary ingress and egress in
and out of the premises as may be required by applicable laws and (c) in
ensuring that the vacant space meets applicable code requirements.  Any work required to be completed in Premises
A 2007, or in the adjacent premises still occupied by Tenant after vacating
Premises A 2007, in order to ensure such compliance and to segregate the vacant
space from the occupied space shall be performed by Landlord, at Landlord’s
cost, during normal business hours; provided, however, that Landlord shall use
reasonable efforts to minimize any disruption to Tenant’s use of its
premises.  Subject to the provisions
hereof, Tenant agrees to provide Landlord and its contractors with ready access
to the remaining premises occupied by Tenant, during normal business hours, to
complete such work; provided, however, that Landlord shall use reasonable
efforts to minimize any disruption to Tenant’s use of its premises.  Tenant acknowledges and agrees that the
operation of the plumbing and electric systems and the furnishing of heating
and air conditioning services to the premises still occupied by the Tenant may
be temporarily interrupted as a result of the work contemplated in this
paragraph.  Landlord shall exercise
reasonable diligence to minimize any such interruption, and provided that
Landlord exercises such efforts, there shall be no diminution or abatement of
rent or other compensation due from Landlord to Tenant as a result of such
interruption, nor shall the Leases be affected or any of Tenant’s obligations
under the Leases be reduced, and Landlord shall have 

 5
 

no responsibility or
liability for any such interruption of services or systems provided that
Landlord is acting with reasonable diligence as set forth herein.  Landlord, at Landlord’s sole cost and
expense, shall be responsible for any damage to Tenant’s property or the
premises caused in whole or in part by Landlord’s negligent act or omission
relative to the segregation of the premises as contemplated by this paragraph
15.  Notwithstanding any provision to the
contrary contained herein, Tenant shall have the right at all times to have an
agent or representative of Tenant accompany Landlord, Landlord’s contractors,
licensees, agents, servants, employees, invitees or visitors or anyone entering
any portion of Premises B, Premises A 2007 or Premises A 2008 at Landlord’s
discretion or on Landlord’s behalf.

16.           Removal of Tenant’s Wiring.  Tenant agrees to reimburse Landlord for
one-half of the actual cost reasonably incurred by Landlord for the removal of
all telecommunications lines and cabling installed by Tenant in Premises B,
Premises A 2007 or Premises A 2008, including, without limitation, any such
lines and cabling installed in the plenum or risers of Building 600 and/or
Building 1400 (“Tenant’s Wiring”). 
Landlord shall deliver a written statement to Tenant, providing
reasonable detail of the work performed and the costs incurred by
Landlord.  In no event shall Tenant’s
reimbursement obligation exceed $100,000 in the aggregate.  Landlord shall not commence the removal of
Tenant’s Wiring in a particular portion of the premises until after the
expiration of the term for the respective portion of the premises.  However, in the event Tenant vacates any
portion of Premises B, Premises A 2007 or Premises A 2008 prior to the
scheduled expiration date of the term as set forth in this Third Amendment,
Landlord shall be permitted to remove Tenant’s Wiring from the vacated space
immediately upon Tenant’s surrender of said space to Landlord provided Landlord
can complete such removal without unreasonably interfering with Tenant’s
business operations in the remaining space occupied by Tenant.

17.           Notices.  For all purposes of the Leases, the notice
address for Landlord shall hereafter be as follows: RB Kendall Fee, LLC, One
Kendall Square, Cambridge, Massachusetts 02139. 
Any notices given to Landlord shall be delivered in accordance with the
terms of the Leases to the foregoing address with copies to be delivered in
like manner to Landlord, c/o The Beal Companies, LLP, 177 Milk Street, Boston,
Massachusetts, Attention: Stephen N. Faber, Vice President and to Sherin and
Lodgen, LLP, 101 Federal Street, Boston, Massachusetts 02110, Attention: Peter
A. Spellios, Esquire.

For all purposes
of the Leases, the notice address for Tenant shall hereafter be as
follows:  Genzyme Corporation, MetroWest
Summit, 11 Pleasant Street Connector, Framingham, Massachusetts 01701, Attn:
Henry Fitzgerald.  Any notices given to
Tenant shall be delivered in accordance with the terms of the Leases to the
foregoing address with copies to be delivered in like manner to:  Genzyme Corporation, 500 Kendall Street,
Cambridge, Massachusetts 02142, Attn: Bob Hesslein, Esq., and to Edwards Angell
Palmer & Dodge, 111 Huntington Avenue, Boston, Massachusetts 02199, Attn:
Thomas G. Schnorr, Esq.

Notwithstanding
any provision in the Leases to the contrary, any notices or other
communications under the Leases may be delivered in person, by nationally
recognized commercial delivery service, next business day delivery, certified
mail with return receipt requested or by registered mail, postage prepaid.

18.           Brokers.  Landlord and Tenant each warrant and
represent to the other that they have dealt with no brokers in connection with
the negotiation or consummation of this Third Amendment other than Lincoln
Property Company and Trammell Crow Company (the “Brokers”) and in the event of
any brokerage claim against either party by any person claiming to have dealt
with either Landlord or Tenant in connection with this Third Amendment, other
than the Brokers, the party with whom such person claims to have dealt shall
defend and indemnify the other party against such claim.  Landlord shall pay any commission due the
Brokers pursuant to a separate agreement.

 6
 

 

19.           In all other respects the Leases
shall remain unmodified and shall continue in full force and effect, as amended
hereby.  The parties hereby ratify,
confirm, and reaffirm all of the terms and conditions of the Leases, as amended
hereby.

 

[Signatures appear
on next page]

 7
 

 

IN WITNESS WHEREOF the parties hereto have executed
this Third Amendment of Leases on the date first written above in multiple
copies, each to be considered an original hereof, as a sealed instrument.

	
  

  	
   

  	
  LANDLORD:

  	
   

  	
  TENANT:

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  RB KENDALL FEE, LLC

  	
   

  	
  GENZYME CORPORATION

  
	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By: 

  	
  Beal Kendall LLC, its authorized signatory

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  By:

  	
  /s/ Robert L. Beal

  	
   

  	
  By:

  	
  /s/ Mark Bamforth

  
	
   

  	
   

  	
   

  	
  Robert L. Beal, its manager

  	
   

  	
  Name:

  	
  Mark Bamforth

  
	
   

  	
   

  	
   

  	
   

  	
  Title:

  	
  Senior Vice President

  

 

 8

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