Document:

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                                                                   EXHIBIT 10.39

                                 PROMISSORY NOTE

                                     9/26/03
                                     ------
                                     (DATE)

FOR VALUE RECEIVED, LA JOLLA PHARMACEUTICAL COMPANY a corporation located at the
address stated below ("MAKER") promises, jointly and severally if more than one,
to pay to the order of GENERAL ELECTRIC CAPITAL CORPORATION or any subsequent
holder hereof (each, a "PAYEE") at its office located at 401 MERRITT 7 SUITE 23,
NORWALK, CT 06851-1177 or at such other place as Payee or the holder hereof may
designate, the principal sum of ONE HUNDRED FORTY-NINE THOUSAND FOUR HUNDRED
EIGHTY-NINE AND 59/100 DOLLARS ($149,489.59), with interest on the unpaid
principal balance, from the date hereof through and including the dates of
payment, at a fixed interest rate of Eight and Twenty Seven Hundredths percent
(8.27%) per annum, to be paid in lawful money of the United States, in Forty-Two
(42) consecutive monthly installments of principal and interest as follows:

<TABLE>
<CAPTION>
  Periodic
 Installment           Amount
 -----------           ------
<S>                 <C>
Thirty-Six (36)     $   4,131.46
Five (5)            $   3,748.16
</TABLE>

each ("Periodic Installment") and a final installment which shall be in the
amount of the total outstanding principal and interest. The first Periodic
Installment shall be due and payable on 10/1/03 and the following
Periodic Installments and the final installment shall be due and payable on the
same day of each succeeding month (each, a "Payment Date"). Such installments
have been calculated on the basis of a 360 day year of twelve 30-day months.
Each payment may, at the option of the Payee, be calculated and applied on an
assumption that such payment would be made on its due date.

The acceptance by Payee of any payment which is less than payment in full of all
amounts due and owing at such time shall not constitute a waiver of Payee's
right to receive payment in full at such time or at any prior or subsequent
time.

The Maker hereby expressly authorizes the Payee to insert the date value is
actually given in the blank space on the face hereof and on all related
documents pertaining hereto.

This Note may be secured by a security agreement, chattel mortgage, pledge
agreement or like instrument (each of which is hereinafter called a "SECURITY
AGREEMENT").

Time is of the essence hereof. If any installment or any other sum due under
this Note or any Security Agreement is not received within ten (10) days after
its due date, the Maker agrees to pay, in addition to the amount of each such
installment or other sum, a late payment charge of five percent (5%) of the
amount of said installment or other sum, but not exceeding any lawful maximum.
If (i) Maker fails to make payment of any amount due hereunder within ten (10)
days after the same becomes due and payable; or (ii) Maker is in default under,
or fails to perform under any term or condition contained in any Security
Agreement, then the entire principal sum remaining unpaid, together with all
accrued interest thereon and any other sum payable under this Note or any
Security Agreement, at the election of Payee, shall immediately become due and
payable, with interest thereon at the lesser of eighteen percent (18%) per annum
or the highest rate not prohibited by applicable law from the date of such
accelerated maturity until paid (both before and after any judgment).

Notwithstanding anything to the contrary contained herein or in the Security
Agreement, Maker may not prepay in full or in part any indebtedness hereunder
without the express written consent of Payee in its sole discretion.

It is the intention of the parties hereto to comply with the applicable usury
laws; accordingly, it is agreed that, notwithstanding any provision to the
contrary in this Note or any Security Agreement, in no event shall this Note or

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any Security Agreement require the payment or permit the collection of interest
in excess of the maximum amount permitted by applicable law. If any such excess
interest is contracted for, charged or received under this Note or any Security
Agreement, or if all of the principal balance shall be prepaid, so that under
any of such circumstances the amount of interest contracted for, charged or
received under this Note or any Security Agreement on the principal balance
shall exceed the maximum amount of interest permitted by applicable law, then in
such event (a) the provisions of this paragraph shall govern and control, (b)
neither Maker nor any other person or entity now or hereafter liable for the
payment hereof shall be obligated to pay the amount of such interest to the
extent that it is in excess of the maximum amount of interest permitted by
applicable law, (c) any such excess which may have been collected shall be
either applied as a credit against the then unpaid principal balance or refunded
to Maker, at the option of the Payee, and (d) the effective rate of interest
shall be automatically reduced to the maximum lawful contract rate allowed under
applicable law as now or hereafter construed by the courts having jurisdiction
thereof. It is further agreed that without limitation of the foregoing, all
calculations of the rate of interest contracted for, charged or received under
this Note or any Security Agreement which are made for the purpose of
determining whether such rate exceeds the maximum lawful contract rate, shall be
made, to the extent permitted by applicable law, by amortizing, prorating,
allocating and spreading in equal parts during the period of the full stated
term of the indebtedness evidenced hereby, all interest at any time contracted
for, charged or received from Maker or otherwise by Payee in connection with
such indebtedness; provided, however, that if any applicable state law is
amended or the law of the United States of America preempts any applicable state
law, so that it becomes lawful for the Payee to receive a greater interest per
annum rate than is presently allowed, the Maker agrees that, on the effective
date of such amendment or preemption, as the case may be, the lawful maximum
hereunder shall be increased to the maximum interest per annum rate allowed by
the amended state law or the law of the United States of America.

The Maker and all sureties, endorsers, guarantors or any others (each such
person, other than the Maker, an "OBLIGOR") who may at any time become liable
for the payment hereof jointly and severally consent hereby to any and all
extensions of time, renewals, waivers or modifications of, and all substitutions
or releases of, security or of any party primarily or secondarily liable on this
Note or any Security Agreement or any term and provision of either, which may be
made, granted or consented to by Payee, and agree that suit may be brought and
maintained against any one or more of them, at the election of Payee without
joinder of any other as a party thereto, and that Payee shall not be required
first to foreclose, proceed against, or exhaust any security hereof in order to
enforce payment of this Note. The Maker and each Obligor hereby waives
presentment, demand for payment, notice of nonpayment, protest, notice of
protest, notice of dishonor, and all other notices in connection herewith, as
well as filing of suit (if permitted by law) and diligence in collecting this
Note or enforcing any of the security hereof, and agrees to pay (if permitted by
law) all expenses incurred in collection, including Payee's actual attorneys'
fees. Maker and each Obligor agrees that fees not in excess of twenty percent
(20%) of the amount then due shall be deemed reasonable.

THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM
OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY OR INDIRECTLY, THIS
NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE
RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS,
AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN MAKER AND PAYEE. THE
SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES
THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS,
TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY
CLAIMS.) THIS WAIVER IS IRREVOCABLE MEANING THAT IT MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS,
RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR
TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED
TRANSACTION. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN
CONSENT TO A TRIAL BY THE COURT.

This Note and any Security Agreement constitute the entire agreement of the
Maker and Payee with respect to the subject matter hereof and supercedes all
prior understandings, agreements and representations, express or implied.

<PAGE>

No variation or modification of this Note, or any waiver of any of its
provisions or conditions, shall be valid unless in writing and signed by an
authorized representative of Maker and Payee. Any such waiver, consent,
modification or change shall be effective only in the specific instance and for
the specific purpose given.

Any provision in this Note or any Security Agreement which is in conflict with
any statute, law or applicable rule shall be deemed omitted, modified or altered
to conform thereto.

                               LA JOLLA PHARMACEUTICAL COMPANY

/s/ Lisa Peraza                By:  /s/ Gail A. Sloan
-----------------------             ------------------------------------------
(Witness)
Lisa Peraza                    Name: Gail A. Sloan
-----------------------
(Print name)
6455 Nancy  Ridge Drive        Title: Senior Director of Finance and Controller
San Diego, CA 92121
(Address)

                               Federal Tax ID #: 330361285

                               Address:   6455 Nancy Ridge Drive, San Diego,
                               San Diego County, CA 92121<PAGE>

                                                                   EXHIBIT 10.40

                             LEASE RENEWAL AMENDMENT
                                   1045179-001

         THIS LEASE RENEWAL AMENDMENT dated as of July 1, 2003 ("Amendment")
amends Schedule No. SG02 ("Schedule") to the Master Lease Agreement dated as of
September 13, 1995 ("Agreement"), such Schedule and Agreement, as the same may
have been heretofore amended or otherwise modified, are hereinafter collectively
referred to as the ("Lease") between General Electric Capital Corporation
Successor In Interest to Comdisco, Inc. as of February 25, 2002 ("Lessor") and
La Jolla Pharmaceutical Company ("Lessee"). Capitalized terms not defined herein
shall have the meanings assigned to them in the Lease.

                               W I T N E S S E T H

         WHEREAS, the term of the Lease is scheduled to expire on June 30, 2003
("Primary Term Expiration Date"); and

         WHEREAS, Lessee desires to renew the Lease pursuant to the terms set
forth herein; and

         WHEREAS, Lessor is willing to consent to such renewal pursuant to the
terms set forth herein;

         NOW, THEREFORE, in consideration of the above premises and the mutual
promises contained herein, as well as other good and valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the parties hereto,
intending to be legally bound, agree as follows:

     1.  Commencing on July 1, 2003, the Lease shall be renewed for an
         additional period of Twenty Four (24) months ("Renewed Term") on and
         subject to the same terms and conditions as set forth in the Lease,
         except as otherwise expressly provided herein:

         (a)      During the Renewed Term, Lessee hereby agrees to pay to Lessor
                  rent in the total principal sum One Hundred Eleven Thousand
                  and 00/100 Dollars ($111,000.00), with interest thereon, from
                  the date upon which the Renewed Term commences through and
                  including the last day of the Renewed Term, at a fixed
                  interest rate of Seven percent (7.0%), to be paid in Eight (8)
                  consecutive Quarterly installments of principal and interest
                  of Fourteen Thousand Seven Hundred Thirty Seven and 00/100
                  Dollars ($14,737.00) (each a "Periodic Installment") and a
                  final installment equal to the GPO Amount (as that term is
                  described below). The Periodic Installments have been
                  calculated on the basis of a 360 day year of twelve thirty-day
                  months. Each Periodic Installment may, at the option of the
                  Lessor, be calculated and applied on the assumption that such
                  installment would be made on its due date. The first Periodic
                  Installment shall be due and payable on July 1, 2003 and the
                  following Periodic Installments shall be payable on the same
                  day of each month thereafter throughout the Renewal Term.

         (b)      During the Renewed Term, the Stipulated Loss Value and
                  Termination Value of the Equipment as of the applicable
                  calculation date shall be equal to (i) the sum of (A) all then
                  remaining Periodic Installment payments (which would have come
                  due over the balance of the Renewed Term without any
                  termination thereof), and (B) the GPO Amount (set forth
                  hereinbelow), (ii) discounted to its then present value using
                  a discount rate equal to the one year U.S. Treasury Constant
                  Maturity rate in effect as of the date on which the Lease
                  either terminates or the Casualty occurs, as published in the
                  Federal Reserve Statistical Release H.15 (519). Furthermore,
                  in connection with any default or other termination of the
                  Lease prior to the scheduled expiration of the Renewed Term,
                  any surplus net proceeds received by Lessor from the sale,
                  re-lease or other disposition of the Equipment after
                  satisfaction of all amounts payable by Lessee under the Lease
                  shall be remitted to Lessee (except to the extent as may be
                  otherwise required by applicable law).

         (c)      Upon expiration of the Renewed Term, Lessee shall purchase for
                  cash consideration all (but not less than all) of the
                  Equipment for an amount equal to One and 00/100 Dollar ($1.00)
                  (the "GPO Amount"), plus all applicable sales, use and other
                  taxes thereon, ON AN "AS IS, WHERE IS" BASIS WITHOUT RECOURSE
                  TO, OR WARRANTY BY, LESSOR OF ANY KIND, NATURE OR DESCRIPTION
                  WHATSOEVER. All other purchase options or renewal options are
                  hereby deleted in their entirety.

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         (d)      In order to secure payment and performance of Lessee's
                  obligations hereunder, Lessee hereby grants Lessor a security
                  interest in (i) the Equipment and in all goods that are or may
                  hereafter become accessions thereto, and (ii) all proceeds of
                  such property, including but not limited to insurance
                  proceeds.

         (e)      Any provisions of the Lease relating to Early Termination,
                  Purchase Option or Terminal Rent Adjustment Clause shall be
                  deleted in their entirety.

     2.  Lessee hereby represents and warrants that all of the representations
         and warranties included in the Lease (except as set forth in Article XV
         (b) of the Lease) are true and correct as of the date first above
         written.

     3.  Except as expressly modified herein, all terms and provisions of the
         Lease shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have caused their duly
         authorized representatives to execute and deliver this Amendment as of
         the date first above written.

LESSOR:                         LESSEE:
GENERAL ELECTRIC CAPITAL        LA JOLLA PHARMACEUTICAL COMPANY
CORPORATION SUCCESSOR IN
INTEREST TO COMDISCO INC.
AS OF FEBRUARY 25, 2002

By: /s/ Michael J. Fernand      By: /s/ Gail A. Sloan
   -------------------------       --------------------------------------------

Title: Collateral Specialist    Title: Senior Director of Finance and Controller

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