Document:

SAVE DAILY, INC. CONSENT TO ACTION BY BOARD OF DIRECTORS

WITHOUT A MEETING

 

The undersigned, being the members of the Board of Directors
of SaveDaily, Inc. a Nevada corporation (the “Company”), hereby approve and adopt the following resolution by written
consent pursuant to the Nevada Revised Statutes (“NRS”) effective as of March 13, 2013.

 

WHEREAS, Michael Cronin, the Company’s CFO, tendered
his resignation on May 2, 2013 to be effective May 16, 2013.

 

WHEREAS, the Directors believe it is in the best interest of
the Company to accept the resignation of Michael Cronin.

 

WHEREAS, Jeff Mahony, the Company’s current CEO, is best
suited to assume the responsibilities of the CFO.

 

NOW, THEREFORE, BE IT RESOLVED, that the resignation of Michael
Cronin as CFO of the Company is accepted effective May 16, 2013.

 

BE IT RESOLVED FURTHER, that the Board of Directors appoints
Jeff Mahony as CFO, effective May 16, 2013 to serve at the pleasure of the Board.

 

BE IT RESOLVED FURTHER, that the Company authorizes and directs
the officers and directors of to prepare and file any documents and take any actions as are necessary or advisable in connection
with the resignation of Michael Cronin and appointment of Jeff Mahony.

 

BE IT RESOLVED FURTHER, that any and all actions heretofore
taken by any officer of the Company in connection with the matters contemplated by the foregoing resolution be, and they hereby
are, approved, ratified and confirmed in all respects as fully as if such actions had been presented to the undersigned for their
approval prior to such actions being taken; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors may be executed by facsimile signature and any such facsimile signature shall be deemed to be an original
signature of the party or parties who executed in such manner; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors may be executed by affirmative electronic email response and any such affirmative email response shall
be deemed to be an original signature of the party or parties who executed in such manner; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors shall be maintained with the minutes of the proceedings of the Company’s Board of Directors and
the Shareholders.SAVE DAILY.COM, a California Corporation

 

A WHOLLY OWNED
SUBSIDIARY OF SAVE DAILY, INC., a Nevada Corporation

 

CONSENT TO ACTION
BY BOARD OF DIRECTORS WITHOUT A MEETING

 

The undersigned directors of SaveDaily.com, Inc., a California
corporation (the “Company”), acting pursuant to the authority set forth in Section 307 of the California General Corporation
Law (the “Corp. Code”) and the authority granted in the bylaws of the Company, do hereby adopt the following resolutions
by unanimous written consent, effective as of May 13, 2013.

 

WHEREAS, Michael Cronin, the Company’s CFO, tendered his
resignation on May 2, 2013 to be effective May 16, 2013.

 

WHEREAS, the Directors believe it is in the best interest of
the Company to accept the resignation of Michael Cronin.

 

WHEREAS, Jeff Mahony, the Company’s current CEO, is best
suited to assume the responsibilities of the CFO.

 

NOW, THEREFORE, BE IT RESOLVED, that the resignation of Michael
Cronin as CFO of the Company is accepted effective May 16, 2013.

 

BE IT RESOLVED FURTHER, that the Board of Directors appoints
Jeff Mahony as CFO, effective May 16, 2013 to serve at the pleasure of the Board.

 

BE IT RESOLVED FURTHER, that the Company authorizes and directs
the officers and directors of to prepare and file any documents and take any actions as are necessary or advisable in connection
with the resignation of Michael Cronin and appointment of Jeff Mahony.

 

BE IT RESOLVED FURTHER, that any and all actions heretofore
taken by any officer of the Company in connection with the matters contemplated by the foregoing resolution be, and they hereby
are, approved, ratified and confirmed in all respects as fully as if such actions had been presented to the undersigned for their
approval prior to such actions being taken; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors may be executed by facsimile signature and any such facsimile signature shall be deemed to be an original
signature of the party or parties who executed in such manner; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors may be executed by affirmative electronic email response and any such affirmative email response shall
be deemed to be an original signature of the party or parties who executed in such manner; and

 

BE IT RESOLVED FURTHER, that this Unanimous Written Consent
of the Board of Directors shall be maintained with the minutes of the proceedings of the Company’s Board of Directors and
the Shareholders.Exhibit 10.1

 

Confidential Treatment –
Asterisked material has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment.

 

[123I]NAV5001 Clinical Supply
Agreement

 

THIS AGREEMENT made in duplicate as of this
10th day of May, 2013

 

BETWEEN:

 

Nordion (Canada) Inc.

having a place of business at

447 March Road

Ottawa, Ontario, Canada

 

(“Nordion”)

 

AND:

 

Navidea Biopharmaceuticals, Inc.

having a place of business at

425 Metro Place North, Suite 450

Dublin, OH 43017-1367, USA

 

(“Navidea”)

 

WHEREAS:

 

		I.	Navidea is the licensee of a certain compound known as [123I]NAV5001, an I-123 radiolabeled
diagnostic agent;

 

		II.	Navidea has the techniques and has demonstrated an ability to label a specific precursor molecule
with I-123 to form [123I]NAV5001;

 

		III.	Nordion has expertise in the production of radiochemicals, and in the development of radiopharmaceuticals,
processes, and radiolabelling of compounds;

 

		IV.	Nordion has available for use a facility in Vancouver, British Columbia, suitable for the manufacture
and supply of [123I]NAV5001 to be used in Clinical Trials.

 

		V.	Navidea desires that Nordion establish a development program at its site in Vancouver, British
Columbia, for the purpose of radiolabelling Navidea’s Precursor with I-123 to form [123I]NAV5001; and

 

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		VI.	Navidea desires that Nordion manufacture and supply [123I]NAV5001 for its Clinical Trials.

 

NOW THEREFORE in consideration of the mutual
covenants and agreements herein contained, and subject to the terms and conditions hereinafter set out, the parties hereto agree
as follows:

 

ARTICLE 1 – DEFINITIONS

 

For the purposes of this Agreement:

 

		1.1	“Affiliate” shall mean an entity or person which controls, is controlled by
or is under common control with either party. For purposes of this Section 1.1 control shall mean: (a) in the case of corporate
entities, the direct or indirect ownership of more than one-half of the stock or participating shares entitled to vote for the
election of directors; and (b) in the case of a partnership, the power to direct the management and policies of such partnership.

 

		1.2	“Batch” shall mean a production batch of [123I]NAV5001 manufactured
under this Agreement in accordance to the Batch Sizes set out in Schedule D.

 

		1.3	“Batch Fee” shall mean the price of each Batch as set out in Schedule D.

 

		1.4	“Scheduled Batch Production Date” shall mean the production date on which Isotope
is scheduled to be added to Precursor during the Manufacture of [123I]NAV5001.

 

		1.5	“Clinical Trials” shall mean human studies of [123I]NAV5001 for the
purpose of seeking pharmaceutical regulatory approval in Canada and United States.

 

		1.6	“Current Good Manufacturing Practices” or “cGMP(s)” shall
mean (1) the good manufacturing practices required by the FDA and as set forth in the FD&C or FDA rules and regulations for
the manufacturing, testing and quality control of pharmaceutical materials as applied to compounds, as of the Effective Date of
this Agreement and as may be supplemented, amended or modified from time to time; and (2) to the extent applicable to Nordion's
activities hereunder, any rules, regulations and standards required by Health Canada for the manufacturing, testing and quality
control of pharmaceutical materials as applied to compounds, as of the Effective Date of this Agreement and as may be supplemented,
amended or modified from time to time.

 

		1.7	“Commercially Reasonable Efforts” means, with respect to the efforts to be extended
by a party with respect to any activity under this Agreement, exercising reasonable efforts, good faith and diligence in accordance
with a party’s reasonable business judgment.

 

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		1.8	“Confidential Information” means all non-public information disclosed, directly
or indirectly, by one party to the other, whether disclosed orally, in writing or other tangible form, relating to technical or
non-technical data, Nordion Background Technology, Navidea Background Technology, designs, drawings, know-how, formulas, policies,
plan reports, trade secrets, processes, methods, product developments, material samples, business plans, forecasts, marketing plans,
customer lists, business strategies and other documentation or information of a technical, financial or otherwise proprietary or
confidential nature and such other information as clearly marked by the disclosing party as proprietary or confidential.

 

		1.9	“Data” shall mean respectively, [123I]NAV5001 and its predecessor
product known as AltropaneTM formulation data and data summaries, data reports, stability testing reports, production batch
records, and validation reports generated under this Agreement and previously generated under the agreement between Nordion (Canada)
Inc. (previously known as MDS Nordion Inc.) and [*] dated August 9, 2000, as amended. Data shall exclude Nordion Background Technology
and Nordion Confidential Information.

 

		1.10	“Effective Date” shall mean the date first appearing above.

 

		1.11	“Equipment” means any equipment or machinery, and in the case of cGMP manufacturing
hereunder, qualified equipment or machinery, used by Nordion in the development and/or Manufacture of [123I]NAV5001
or the holding, processing, testing, or release of [123I]NAV5001.

 

		1.12	“FDA” shall mean the United States Food and Drug Administration.

 

		1.13	“FD&C” shall mean the United States Federal Food, Drug and Cosmetic Act,
as amended from time to time.

 

		1.14	“Facility” shall mean the facility to be returned to operation by Nordion at
its manufacturing site in Vancouver, British Columbia, as described in Schedule A, to be used for the production of [123I]NAV5001.

 

		1.15	“Facility Milestone(s)” shall mean the milestones relating to the return to
operation of the Facility as described in Schedule A.

 

		1.16	“Facility Program” shall mean the program by which Nordion shall return the
Facility to operation in accordance with the Facility Milestones as described in Schedule A.

 

		1.17	“IND” shall mean an Investigational New Drug Application as defined by the rules
and regulations promulgated under the FD&C and related FDA rules and regulations as supplemented, modified or amended from
time to time.

 

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		1.18	“Isotope” or “I-123” shall mean Iodine 123.

 

		1.19	“Manufacture (d) (ing)” means any processes and activities necessary to produce
[123I]NAV5001, including without limitation, the processing, packaging, labeling, quality control testing, stability
testing, release or storage of Precursor, Reference Standards and [123I]NAV5001.

 

		1.20	“Master Batch Record” or “MBR” shall mean a formal set of
instructions for the Manufacture of each Batch developed and maintained in Nordion’s standard format by Nordion.

 

		1.21	”Master Validation Plan” shall mean the program by which documented evidence
provides assurance that the Process will consistently produce [123I]NAV5001 that meets Specifications.

 

		1.22	“[123I]NAV5001” shall mean Navidea’s proprietary I-123 labeled diagnostic agent [*].

 

“NAV5001” shall mean [*].

 

“NAV5010” shall mean [*].

 

“NAV5011” shall mean [*].

 

		1.23	“NDA” shall mean a new drug application seeking mandatory authorization in the
United States as defined in the rules and regulations promulgated under the FD&C and related FDA rules and regulations, as
supplemented, modified or amended from time to time.

 

		1.24	“Navidea Background Technology” shall mean proprietary technology conceived,
created, developed, reduced to practice, or acquired (by assignment, license or otherwise) by Navidea prior to or during the Term
of this Agreement or independently of this Agreement, and independently of Nordion Background Technology including, without limitation,
patents, works of authorship, know-how, concepts, ideas, techniques, methods, processes, drawings, schematics, procedures, protocols,
parameters, engineering details, functional descriptions, data and database content, technical or scientific information, manuals
and trade secrets, which Navidea owns, uses, conceives, creates, develops, reduces to practice or provides in performing under
this Agreement, or which is licensed to Navidea which is in existence in the form of a writing, prototype or can otherwise be demonstrated
to be the property of Navidea, or to which Navidea has the rights. For purposes of clarity, Navidea Background Technology shall
include the Process to the extent contributed by Navidea and the Data and does not include Nordion Background Technology.

 

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		1.25	“Nordion Background Technology” shall mean proprietary technology, conceived,
created, developed or reduced to practice, or acquired (by assignment, license or otherwise) by Nordion prior to or during the
Term of the Agreement (except for the Process to the extent contributed by Navidea and Data) or independently of this Agreement,
including, without limitation, patents, know-how, techniques, methods, processes, drawings, schematics, procedures, protocols,
parameters, engineering details, functional descriptions, data and database content, technical or scientific information, manuals
and trade secrets, which Nordion owns, uses, conceives, creates, develops, reduces to practice or provides in performing under
this Agreement, or which is licensed to Nordion and which is in existence in the form of a writing, prototype or can otherwise
be demonstrated to be the property of Nordion, or to which Nordion has the rights. For the purposes of clarity Nordion Background
Technology does not include Navidea Background Technology.

 

		1.26	“Precursor” shall mean NAV5010.

 

		1.27	“Process” shall mean the method of producing [123I]NAV5001 from the
Precursor, including the radiolabelling of Precursor with I-123, as well as the formulation, dispensing and testing of [123I]NAV5001
pursuant to this Agreement and previously generated under the agreement between Nordion (Canada) Inc. (previously known as MDS
Nordion Inc. and [*] dated August 9, 2000, as amended.

 

		1.28	“Quality Agreement” shall mean an agreement substantially in the form set out
in Schedule E or as agreed upon by the parties subsequent to the execution of this Agreement.

 

		1.29	“Regulatory Authority” shall mean Health Canada and the United States Food and
Drug Administration.

 

		1.30	“Reference Standards” shall mean NAV5001 and NAV5011.

 

		1.31	“Specification(s)” shall mean those final conditions, characteristics and specifications
for [123I]NAV5001 as set out in Schedule B, as amended by mutual written agreement of the parties from time to time.

 

		1.32	“Term” shall mean Term as defined in Section 17.1.

 

The following Schedules attached to this
Agreement are hereby incorporated by reference:

 

Schedule
A:         Description of Facility Program, Milestones and Project Schedule

 

Schedule
B:         [123I]NAV5001 Specifications

 

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 Schedule
C:        Fees for Facility Program and Return to Operation of the Facility
for Clinical Supply of [123I]NAV5001

 

Schedule
D:         Price of Batches for Clinical Trials’ Supply

 

Schedule
E:         Quality Agreement

 

Schedule
F:         Amounts and Specifications for Precursor and Reference Standards

 

Schedule
G:         Change in Scope Form

 

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ARTICLE 2 – PURPOSE

 

		2.1	Scope and Object

 

The scope and object of this
Agreement is to prepare the Facility for the Manufacture of [123I]NAV5001, refine the Process as necessary for the Manufacture
of [123I]NAV5001, and to subsequently Manufacture [123I]NAV5001 for use in Clinical Trials.

 

ARTICLE 3 – FACILITY PROGRAM,
AUDITS, MAINTENANCE

 

		3.1	Facility Program 

 

In consideration of the provision
of services and activities carried out by Nordion in returning the Facility to operation, Navidea will pay to Nordion the fees
as set out in Schedule C plus any applicable taxes. Unless otherwise set out, amounts owed by Navidea during the Facility Program
shall be paid in accordance with Section 5.2.

 

Nordion shall establish the Facility
in accordance with its obligations described and attributed in Schedule A, it being understood that some activities may be reasonably
delayed to the extent that such activity is premised on the work or provision of data, information, Equipment or technology by
Navidea and that some activities may be delayed if such activities materially interfere or could be reasonably expected to interfere
with other established Nordion production activities. It is understood and acknowledged by Navidea that due to the nature of Nordion
business and ongoing activities (including, without limitation, those activities carried on in rooms 112 A and 112 B at Nordion’s
site) there may be delays incurred in carrying out the obligations and achieving the milestones set out in this Agreement. Nordion
will use Commercially Reasonable Efforts to minimize such delays and will keep Navidea advised of such situations during biweekly
the calls or more often on an urgent basis as, and when, required.

 

Nordion recognizes the importance
of the [123I]NAV5001 program to Navidea and will place due and reasonable priority on the Facility Program work. Therefore,
in carrying out the Facility Program Phase, Nordion will apply the necessary and appropriate resources in carrying out its obligations
and activities set out in this Agreement.

 

Subject to the foregoing each
party shall use their Commercially Reasonable Efforts in order to carry out their respective obligations and responsibilities set
out in Schedule A in order to prevent or minimize delays in meeting Facility Milestones and each will keep the other advised of
any situations which may result in such delays during biweekly calls or more often on an urgent basis as and when, required.

 

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 Nordion shall, in consultation
with Navidea, develop and implement a Master Validation Plan that will allow the production of [123I]NAV5001 under
cGMPs for Clinical Trial supply. Prior to implementation, both parties shall in writing approve the Master Validation Plan, which
approval will not be unreasonably or untimely withheld.

 

During the execution of the Facility
Program Navidea will be called upon by Nordion to review and approve certain processes and documentation, as set forth in Schedule
A. Nordion and Navidea agree that a reasonable time period for such reviews and receipt of feedback/approval is five (5) business
days from the time Navidea receives the document and all other information reasonably necessary for such review. Navidea agrees
that it will use Commercially Reasonable Efforts to effect such review and approval in the time period allotted. If the review
by Navidea exceeds the time period allotted, such delay shall, at Nordion’s option, require extension of the project schedule
which will be effected through a scope change to reflect any delays and costs arising from such delay in the review.

 

		3.2	Program Manager

 

The parties, upon signing this
Agreement, shall each designate a program manager, who shall be responsible for coordinating communication and monitoring performance
under this Agreement. The program manager for Nordion shall respond to Navidea’s reasonable inquiries regarding the status
of Nordion’s activities under this Agreement and the Facility Program and shall keep Navidea informed as to interim progress.
In addition, the program managers shall meet either bi-weekly or more frequently than bi-weekly if agreed to in advance by the
parties, in person or by telephone, for the purpose of reviewing the status of the Facilty Program and assessing progress against
the milestones and activities set forth in Schedule A. Minutes of meetings shall be prepared, maintained and provided to each of
the parties. Prior to the scheduled bi-weekly meetings, Nordion shall prepare and submit to Navidea the minutes from the previous
meetings. Nordion will also inform Navidea in the biweekly calls in reasonable detail, the progress of the Facility Program and
indicate any problems that are known to Nordion or reasonably anticipated by Nordion to occur that either may impact the project
schedule for the Facility or may result in a scope change and cost increase to be borne by Navidea.

 

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		3.3	Scientific and Technical Dispute Resolution

 

In the event that at any time
during the Term of this Agreement, a disagreement, dispute, controversy or claim should arise relating to scientific or technical
issues in connection with Nordion's or Navidea's performance under this Agreement, the program managers will attempt, in good faith,
to resolve their differences within a period of ten (10) business days (or less if the circumstances reasonably necessitate a faster
resolution). With respect to such scientific or technical issues, if after ten (10) business days (or less if the circumstances
reasonably necessitate a faster resolution) the program managers are unable to resolve such dispute, the program managers shall
refer the matter to a joint steering committee comprised of at least three (3) senior members of each party who shall, in good
faith, attempt to promptly resolve the matter. If the steering committee cannot resolve the matter, either party may seek any other
remedy available. Notwithstanding the foregoing either party may take any action and seek any remedy it may have in law or equity
without having fully complied with with the above dispute resolution process in order to avoid expiration of any applicable statute
of limitations or as otherwise necessary to prevent irreparable harm.

 

		3.4	Scope change

 

The parties acknowledge and agree
that the project schedule and scope in Schedule A may require amendment during the course of establishing the Facility due to circumstances,
issues or problems which the parties could not have reasonably foreseen in the exercise of commercially reasonable diligence. All
such changes to Schedule A shall be made by written agreement of the parties in the form of a scope change (Schedule G). If any
proposed change to Schedule A impacts the scope of work to be provided by Nordion such that Nordion will be required to provide
(or procure) services, materials or Equipment beyond that agreed to in Schedule A, Nordion will provide Navidea a written quote
of any increased cost and estimated delay, which must be approved by Navidea in advance of implementation. Any such approved changes
in scope shall be charged to Navidea based on the quote provided by Nordion for the work set out in the scope change. No work on
such scope change shall be carried out or implemented by Nordion prior to Nordion’s receipt of Navidea's written approval
of such change and appropriate scope change documentation being completed and signed by both parties.

 

		3.5	Navidea Audits 

 

During
the Term of the agreement, upon ten (10) business days prior written notice to Nordion, Navidea
and/or any third-party consultant or auditor appointed by Navidea,
such consultant and/or auditor being subject to a confidentiality agreement with and reasonably acceptable to Nordion, shall have
reasonable access to audit the Facility, the Process, as well as all applicable Process documents for the purpose of determining
the progress against Facility Milestones and compliance with Schedules A and E. If Navidea elects to conduct more than (two)
2 calendar days of audit, per contract year, then such audits shall be treated as a scope change and the cost for such activities
will be borne by Navidea in accordance with the rates set out in Schedule G. Notwithstanding the foregoing,
should significant non-conformance by or attributable to Nordion be identified during an audit, Nordion will cooperate to resolve
the non-conformance and Navidea will not be liable for Nordion costs incurred associated with such activities nor audit time required
to confirm resolution of such matters.

 

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 ARTICLE 4 –
MANUFACTURE AND PRICING

 

		4.1	[123I]NAV5001 Clinical Supply Readiness and [123I]NAV5001 Clinical Manufacture

 

Nordion shall notify Navidea
in writing of the completion of the Facility return to operation and readiness to Manufacture. After return to operation of the
Facility, Nordion agrees to: (i) use the Process to Manufacture and produce Batches of [123I]NAV5001
(in the Batch Sizes specified on Schedule D) solely for Navidea, and in such numbers as Navidea orders; and (ii) make arrangements
for shipment of [123I]NAV5001 to third parties on behalf of Navidea as directed by Navidea. All doses of [123I]NAV5001
shall be shipped in regulatory approved lead shields. Nordion shall withhold from shipment any Batch, or portion thereof, which
does not conform to the Specifications. All [123I]NAV5001 Manufactured and delivered by Nordion hereunder (i) shall
meet the Specifications and all applicable FDA requirements at the FCA (Incoterms 2010) point of delivery at Nordion’s Facility
; and (ii) shall be Manufactured, and prepared for shipment in accordance with cGMPs, the Quality Agreement, and the Master Batch
Record.

 

Subject to Section 4.6, Nordion
shall ensure that the Facility is available for production runs of [123I]NAV5001 at least once per week, on Wednesdays
or on another day that the parties agree to in advance of any Scheduled Batch Production Date.

 

		4.2	Clinical Trial Pricing

 

The purchase price for a Batch
supplied to Navidea for Clinical Trials shall be as set out in Schedule D and shall be payable as set forth in Section 5.2 herein.
All orders for [123I]NAV5001 shall be forwarded by Navidea for receipt by Nordion at least seven (7) calendar days prior
to the Scheduled Batch Production Date on which [123I]NAV5001 is requested to be Manufactured.

 

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		4.3	Minimum Purchase Obligation 

 

Commencing in the first full
month after return to operation and readiness to Manufacture (as notified by Nordion to Navidea pursuant to Section 4.1), Navidea
shall, during the remainder of the Term, purchase or otherwise pay Nordion for a minimum of [*]. In the event the minimum purchase
obligations described in this Section 4.3 are not met by Navidea in any given month, Nordion may without liability, in addition
to any other remedy available, at its sole option and unfettered discretion upon written notice to Navidea: (i) suspend Manufacture
of [123I]NAV5001 until full payment is made by Navidea (during which period the minimum purchase commitment shall continue
to accrue); and/or (ii) terminate this Agreement upon ten (10) days prior written notice to Navidea. In the event that Nordion
elects to suspend Manufacture of [123I]NAV5001 due to Navidea’s failure to meet its minimum purchase obligation
pursuant to this Section 4.3 and Navidea subsequently cures such failure, Nordion agrees to resume Manufacture of [123I]NAV5001
within fifteen (15) business days of such cure.

 

		4.4	Facility Reservation Fees

 

If at any time during the Term
of this Agreement and after Nordion has provided written notice of the Facility readiness to Manufacture [123I]NAV5001
pursuant to Section 4.1, the use of the Facility is delayed or Manufacturing of [123I]NAV5001 is temporarily or otherwise
halted for reasons not attributable to Nordion’s negligent acts or omissions, for a period of greater than or equal to three
(3) consecutive months then, Navidea upon written notice thereof to Nordion, in lieu of the minimum purchase commitments set out
in Section 4.3, shall pay to Nordion a facility reservation fee of [*], thereafter (or prorated portion thereof as applicable),
which payment shall be due and payable on the first day of each month. The temporarily suspended minimum purchase commitment shall
resume immediately upon resolution of the delay or halt preventing use of the Facility for the Manufacture of [123I]NAV5001.

 

		4.5	Batch Cancellation

 

Subject to the terms and conditions
of this Agreement and subject to the minimum purchase commitment in Section 4.3, Navidea shall be entitled to cancel any Batch
ordered from Nordion during the Term of this Agreement by providing to Nordion written notice of cancellation at least seven (7)
calendar days prior to the Scheduled Batch Production Date. For a Batch cancelled by Navidea less than seven (7) calendar days
prior to the Scheduled Batch Production Date, the entire purchase price of the Batch shall be payable by Navidea and the Batch
payment shall be applied against the minimum purchase commitment in Section 4.3.

 

		4.6	Use of the Facility

 

During the Term of this Agreement
Nordion shall ensure that the Facility is available on a non-exclusive basis for the Manufacture of [123I]NAV5001 for
supply to Navidea. Nordion agrees that it shall not: (i) use other facilities for the Manufacture of [123I]NAV5001 unless
Navidea consents to the use of such other facilities in writing, such consent not to be unreasonably withheld; or (ii) Manufacture
[123I]NAV5001 for any third party unless directed to do so in writing by Navidea. Navidea acknowledges that the Facility
is only suitable for Clinical Trial production and supply.

 

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		4.7	Repairs and Maintenance

 

After completion of the Facility
Program, Nordion shall, subject to Section 14.7, maintain such Facility in satisfactory operating condition as required by the
FDA, Specifications, Process, Quality Agreement and cGMPs. The cost of any repairs, preventive maintenance and service contracts
for the Facility and Equipment shall be borne by Nordion. Navidea acknowledges that Nordion may periodically require the Facility
to be unavailable for [123I]NAV5001 production due to repair or unforeseen maintenance activities. In addition, Nordion
may shut down the Facility annually for a two (2) week maintenance period. Such outages, to the extent possible in the circumstance,
shall be subject to eight (8) weeks advance written notice to Navidea and, to the extent possible and reasonable in the circumstance,
be planned in conjunction with Navidea so as to minimize the impact on Nordion’s supply capability of [123I]NAV5001.
Navidea’s obligations under Sections 4.3 and 4.4 shall not apply with respect to any Batch(es) that could not be produced
during a period in which the Facility is unavailable for [123I]NAV5001 production and in such event Navidea’s
calendar month purchase commitment in such months shall be reduced as stated in the plan outlined in Table 1.

 

Table 1

 

	If during any month or month(s) the

Facility is unavailable for a period of 	 	Then Navidea’s monthly minimum

purchase commitment in such month or

months will reduced by
	Less than or equal to 1 week	 	[*]
	More than 1 week and up to 2 weeks	 	[*]
	Greater than 2 weeks	 	[*]

 

 

ARTICLE 5 –PRICE ESCALATION
INVOICE AND PAYMENT

 

		5.1	Price Escalation

 

During the Term of this Agreement
the Batch Fee (Schedule D), scope change labour rates (Schedule G), those fees set out in Section 3.5 (audit activities), and facility
reservation fees set out in Section 4.4, shall be subject to adjustment on each anniversary of the Effective Date in accordance
with the change in the Canadian Consumer Price Index (“CPI”) as published by the Government of Canada. The CPI
will be determined based on the percentage increase in the CPI for the twelve (12) month period ending with the calendar month
which is three (3) months prior to each anniversary of the Effective Date.

 

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		5.2	Currency, Invoice and Payment

 

All sums expressed in this Agreement
shall be in Canadian Currency unless otherwise specified.

 

Nordion shall invoice Navidea
for the Facility Program, purchase price of Batches and such other amounts as are otherwise payable under this Agreement, plus
all applicable taxes. Navidea shall be responsible for all services, sales, use, value added and similar taxes associated with
the products and services provided by Nordion hereunder (specifically excluding taxes in the nature of ordinary personal property
taxes assessed against or payable by Nordion, taxes based upon Nordion’s net income, Nordion's corporate franchise taxes
and the like). Nordion shall have the exclusive responsibility for remittance of all taxes payable and received from Navidea to
the appropriate taxing authorities, and shall be exclusively liable for any penalties, interest and other charges of any jurisdiction
and any other fees or costs arising from Nordion's failure to remit any such applicable taxes. Nordion's invoices hereunder shall
separately itemize such taxes payable by Navidea.

 

All payments will be paid by
Navidea within thirty (30) days of the date Navidea receives Nordion’s invoice, as evidenced by an email, less any amounts
disputed in good faith. Any undisputed amounts which remain unpaid after the aforementioned thirty (30) day period shall bear annual
interest at the rate twelve percent (12%) annually and calculated at the rate of one percent (1%) monthly. Invoices dispatched
by Nordion, shall be deemed received by Navidea as of the date of such email, as evidenced by the date appearing in the email sent
by Nordion. Should Navidea fail to make payments on time on two or more consecutive occasions, Nordion may at its sole option,
modify the future payment terms to require cash in advance of the Scheduled Batch Production date.

 

In the event Navidea disputes
any particular invoiced item or amount, Navidea shall pay the non-disputed portion of the invoice and the parties shall attempt,
in good faith, to resolve the dispute pertaining to the balance payable within fifteen (15) days of receipt of the notice of dispute
issued by either party. In the event that the parties cannot resolve the dispute within the aforementioned fifteen (15) day period
either party may pursue any remedy available under this Agreement or available at law. Navidea's election in good faith to withhold
payment of any disputed amounts shall not excuse Nordion's obligation to perform under this Agreement.

 

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ARTICLE 6 –PRECURSOR AND REFERENCE
STANDARDS

 

		6.1	Precursor and Reference Standards

 

Navidea, or at Navidea’s
discretion, its designee, shall provide to Nordion, at no charge, Precursor and Reference Standards which meet the specifications
in Schedule F in sufficient quantities to permit Nordion to meet its obligations hereunder including but not limited to those obligations
with respect to development, validation runs and Clinical Trials’ supply. Nordion shall only use Precursor and Reference
Standards provided hereunder for the Manufacture of [123I]NAV5001 pursuant to this Agreement. Nordion shall store Precursor
and Reference Standards in accordance with the written instructions provided by Navidea.

 

		6.2	Unavailability or Scarcity of Precursor and/or Reference
Standards

 

After issuance of the notice
of completion of the Facility and return to operation pursuant to section 4.1, Nordion, on a monthly basis, will provide Navidea
with a detailed physical inventory status of NAV5001, NAV5010, and NAV5011 that is available to Manufacture Batches. Navidea will
notify Nordion in writing upon Navidea becoming aware of any shortage or delay of supply of Precursor or Reference Standards if
such shortage or delay will impact the manufacture of [123I]NAV5001. Navidea shall be responsible for any failure of
Precursor or Reference Standards to meet the applicable specifications (Schedule F) and any such shortages, delay or failure to
meet specification which is not attributable to any act, failure to act or other fault of Nordion or Force Majeure, will not relieve
Navidea of its payment obligations pursuant to Section 4.3, Section 4.4 and Section 4.5 and shall excuse Nordion’s performance
of activities related to any affected Batch of [123I]NAV5001 or scheduled Batch production to the extent that Nordion’s
non-performance was caused by the Precursor or Reference Standards supply delay or shortage. To the extent that any Precursor or
Reference Standards supply delays or shortages are attributable to the improper storage or handling of Precursor or Reference Standards
by Nordion, or are attributable to any other act, failure to act or other fault of Nordion, Navidea shall be relieved of its obligations
with respect to affected batches pursuant to Sections 4.3 and 4.4 during the period of any such shortages or delays.

 

		6.3	Compliance with Law and Handling

 

While Precursor, Reference Standards,
Isotope and [123I]NAV5001 are in its possession or under its control, Nordion shall be responsible for compliance in
all material respects with applicable laws, rules and regulations in the United States and Canada related to its possession of
such Precursor, Reference Standards, Isotope and [123I]NAV5001. Navidea shall be responsible for compliance in all material
respects with all applicable laws, rules and regulations relating to its obligations under this Agreement, including but not limited
with respect to the Precursor, Reference Standards, [123I]NAV5001, its Clinical Trials, IND and NDA.

 

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 ARTICLE
7 – [123I]NAV5001 SHIPMENTS 

 

		7.1	Orders and Shipments

 

Navidea will forward orders to
Nordion’s Customer Service team at its Ottawa, Ontario facility, and Nordion shall promptly acknowledge receipt of every
order, by facsimile, email or such other method as agreed by the parties in writing. Each order will reference this Agreement and
set forth the quantity of [123I]NAV5001 to be produced and prepared for shipment, the identity of the recipients, delivery
destination protocol numbers, IND/NDA number, applicable USNRC materials license number and IRS number. Delivery of [123I]NAV5001
to Navidea or as otherwise directed by Navidea shall be FCA (Incoterms 2010) at the Facility. Risk of loss of [123I]NAV5001
shall pass to Navidea at the point of shipment FCA (Incoterms 2010) Nordion’s Facility. The standard terms and conditions
on the reverse side or attached to Navidea’s purchase orders shall not apply and shall be deemed objected to by Nordion,
and of no application.

 

Nordion shall use Commercially
Reasonable Efforts to meet Navidea’s orders and delivery requirements. Prior to the first shipment of [123I]NAV5001
to any third party site, Navidea shall obtain from such third party and provide to Nordion such third party’s license evidencing
proper legal authority for the receipt and possession of [123I]NAV5001 by such third party. Nordion shall be responsible
for compliance with all export formalities necessary for, and the payment of all export duties, taxes and other charges payable
upon, the export of [123I]NAV5001 from Canada, including obtaining at its risk and expense any export license or other
official authorization or other documents necessary therefor. Navidea shall be responsible for compliance with all import formalities
necessary for, and the payment of all import duties, taxes and other charges payable upon, the importation of [123I]NAV5001
into the United States, including obtaining at its risk and expense any import license or other official authorization or other
documents necessary therefor. Nordion shall make shipping arrangements and will coordinate with FedEx or such other carrier designated
by Nordion and reasonably approved by Navidea. All [123I]NAV5001 shipping costs incurred from the FCA (Incoterms 2010)
point of delivery shall be borne by Navidea.

 

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 ARTICLE 8 – PRODUCT WARRANTY AND LIMITED
LIABILITY

 

		8.1	Product Warranty

 

Nordion provides a product warranty
such that each Batch: (i) will conform with the Specifications and all applicable FDA requirements at the FCA (Incoterms 2010)
point of delivery ; and (ii) will be free from defects in material or workmanship and be Manufactured, and prepared for shipment
in accordance with cGMPs, the Master Batch Record, and the Quality Agreement. Nordion further warrants that the [123I]NAV5001
packaging will conform to all applicable packaging regulations, including, but not limited to, those pertaining to packaging and
transport of radioactive materials and radiopharmaceutical products.

 

Navidea will notify Nordion if
Navidea becomes aware of any alleged visible defects, damages or shortage at the time of delivery of [123I]NAV5001 hereunder.
However, a failure to so notify shall not negate any of Nordion's warranties, liabilities, indemnifications or other obligations
set forth herein except to the extent such failure of Navidea to notify results in material prejudice to Nordion. All warranty
obligations of Nordion shall cease and have no effect if the NAV5001 is subject to accident, abuse, misuse, combination, alteration,
neglect or not used or stored by Navidea or its third party, customer, or user, in accordance with the specifications or package
insert. If requested by Nordion, defective product must be held for Nordion’s inspection or returned at Nordion’s expense.

 

If either party discovers or
learns, at any time, that a Batch, including any portion thereof, does not meet the Specifications, was not Manufactured in accordance
with cGMPs, the Master Batch Record or the Quality Agreement, or is mislabeled, adulterated or otherwise defective, then that party
shall promptly communicate with the other party. Without limiting any other rights and remedies Navidea may have under this Agreement,
if Navidea determines that the failure to meet Specifications, failure to Manufacture in accordance with cGMPs, the Master Batch
Record or the Quality Agreement, or any other defect is the result of a negligent act, failure to act or other fault of Nordion,
or agent of Nordion, Nordion will promptly:

 

		(i)	replace such Batch, at no additional cost to Navidea; and

 

		(ii)	pay for shipping costs of replacement of such Batch.

 

In the event that Nordion disputes,
in good faith, Navidea’s determination that the fault is due to Nordion and/or its agent, the parties will select a mutually
acceptable outside consulting firm which will be instructed to review the applicable information and data and confirm or dissent
from Navidea’s determination. If the consulting firm confirms Navidea’s determination, Nordion will have the obligations
set out in this Section and Nordion will pay the fees of such consulting firm. If the consulting firm dissents from Navidea’s
determination or determines that the failure to meet Specifications was due to products, information or services supplied by Navidea,
Nordion will not have the obligations set out in this Section with respect to the disputed Batch and Navidea will pay for such
Batch, return shipping costs and the fees incurred for such consulting firm.

 

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		8.2	Acknowledgement

 

NAVIDEA ACKNOWLEDGES THAT
NORDION IS MANUFACTURING AND SUPPLYING PRODUCT TO MEET SPECIFICATIONS. EXCEPT AS EXPRESSLY SET OUT IN THIS AGREEMENT, NORDION HEREBY
DISCLAIMS ALL OTHER WARRANTIES OR CONDITIONS, WHETHER EXPRESS OR IMPLIED, STATUTORY OR OTHERWISE INCLUDING, BUT NOT LIMITED TO,
ANY IMPLIED WARRANTIES OR CONDITIONS OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, USE OR APPLICATION.

 

		8.3	Disclaimer

 

NORDION’S
LIABILITY TO NAVIDEA FOR DAMAGES HOWSOEVER CAUSED SHALL NOT EXCEED PAYMENT ACTUALLY RECEIVED BY NORDION FOR THE PRODUCT OR SERVICES
FURNISHED HEREUNDER AND EXCEPT IN THE CASE OF THEIR RESPECTIVE INDEMNIFICATION OBLIGATIONS HEREIN, BREACH OF CONFIDENTIALITY, MISAPPROPRIATION
OF THE INTELLECTUAL PROPERTY RIGHTS OF THE OTHER PARTY, WILLFUL MISCONduct, OR GROSS NEGLIGENCE, In no event shall either party
be liable to the other for indirect, contingent, incidental, special or consequential damages, whether in contract, tort, NEGLIGENCE,
STRICT LIABILITY, BREACH OF STATUTORY DUTY or any other cause of action, even if advised of the possibility of such damages.

 

ARTICLE 9 – NONCOMPETE

 

		9.1	During the Term of this Agreement, Nordion will not produce for, or sell or provide to, any third
party [123I]NAV5001 except as instructed by Navidea. For the purpose of certainty, Nordion shall not be restricted in
any way from developing, producing or selling I-123 radiochemical or any other I-123 radiopharmaceutical product or selling any
other product for use in the treatment or diagnosis of Parkinson’s disease, provided that Nordion shall not use any Navidea
Background Technology, the Process to the extent contributed by Navidea, the Data, Confidential Information disclosed or provided
by Navidea, or any other intellectual property of Navidea except for the sole purpose of satisfying its obligations under this
Agreement.

 

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ARTICLE 10 – LICENSE/OWNERSHIP

 

		10.1	Royalty-Free License

 

Navidea hereby provides to Nordion
a non-exclusive, nontransferable (except in connection with the sale of all or substantially all of the assets of Nordion or business
to which this Agreement relates to a third party or in connection with a merger consolidation or similar transaction involving
Nordion), non-sublicensable, fully paid-up, royalty-free, worldwide license during the Term of this Agreement to use Navidea Background
Technology, the Process to the extent contributed by Navidea, Data relating to [123I]NAV5001 and the radiolabelling
of Precursor with I-123, for the sole purpose of assisting Nordion in carrying out its obligations set out in this Agreement.

 

		10.2	Technology Ownership

 

Navidea Background
Technology shall remain the sole and exclusive property of Navidea (or its licensor, as applicable). Nordion Background Technology
shall remain the sole and exclusive property of Nordion. The parties acknowledge and agree that to the extent that the Process
is jointly developed by Nordion and Navidea during the Term of this Agreement then each party may continue to use and exploit such
jointly developed technology as their own technology both during and after the Term of this Agreement.

 

Nothing in
this Agreement permits the use, transfer or license of any right, title or interest to Navidea Background Technology or Nordion
Background Technology, except as expressly set out herein.

 

		10.3	Ownership of Physical Assets, Precursor, Reference
Standards and Data

 

At all times (both during the
Term and after expiration or termination of this Agreement for any reason) Nordion will retain all right and title in and to the
physical assets and real property that comprise and/or are used and/or employed in the Facility.

 

Navidea shall at all times (both
during the Term and after expiration or termination of this Agreement for any reason) retain title to and ownership of Precursor,
Reference Standards, Process to the extent contributed by Navidea and Data, provided further, that both during the Term and after
termination and/or expiration of this Agreement: (i) Nordion may retain an archival copy of the Data for the purpose of management
of its obligations under this Agreement; (ii) Nordion may use the Data for regulatory purposes with respect to [123I]NAV5001;
and (iii) Nordion may use the Data internally, and without disclosing the Data to any third party, for the purpose of increasing
its general knowledge and experience with respect to its radiopharmaceutical capabilities. Nordion will not use Data in any regulatory
submission to any national regulatory authority for the purpose of clinical investigation or licensure of any Nordion produced
[123I]NAV5001 dose form. During the Term of this Agreement, Nordion shall take all such measures as are required to
properly and adequately store the Precursor, Reference Standards, and [123I]NAV5001 in accordance with applicable specifications,
the Master Batch Record, laws and regulations. Nordion shall immediately notify Navidea if at any time it believes any Precursor,
Reference Standards and/or [123I]NAV5001 has been damaged, lost, or stolen.

 

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ARTICLE 11 – NAVIDEA’S
REPRESENTATIONS AND WARRANTIES

 

		11.1	Navidea’s Representations and Warranties

 

Navidea represents and warrants
that:

 

		(i)	it is duly organized, validly existing and in good standing under the laws of the jurisdiction
of its organization;

 

		(ii)	it has full right, power and authority to enter into this Agreement;

 

		(iii)	it is the owner or has the right to use the Navidea Background Technology, and Process (to the
extent provided by Navidea) supplied to Nordion by Navidea to assist Nordion in the Manufacture of [123I]NAV5001 and
in carrying out its obligations hereunder;

 

		(iv)	to Navidea’s knowledge, there is no action or proceeding pending or, to its knowledge, threatened
against Navidea or its licensor with respect to Navidea Background Technology before any court, administrative agency or other
tribunal which would have an adverse material effect on its ability to perform its obligations hereunder;

 

		(v)	it has the right to grant the license in Section 10.1 and it is the owner or otherwise has the
right by license or otherwise (and is not in default thereunder) to permit Nordion to use Navidea Background Technology required
to assist and enable Nordion to carry out its Manufacturing obligations under this Agreement;

 

		(vi)	it has not received any written notice of adverse claim or infringement of any patent or other
intellectual property right, or of misappropriation of trade secrets, in connection with the use and exploitation of Navidea Background
Technology related to its activities under this Agreement or the use and exploitation of the Precursor, Reference Standards or
[123I]NAV5001 or its intended application;

 

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		(vii)	to Navidea’s knowledge, Manufacturing, using, offering for sale or selling of Precursor,
Reference Standards and [123I]NAV5001, and the Navidea Background Technology (and the Process to the extent provided
by Navidea) do not infringe any valid third party patent or other intellectual property right of any third party;

 

		(viii)	it is not under any obligations, contractual or otherwise, to any other entity that might conflict,
interfere or be inconsistent with the execution, delivery or any of the provisions of this Agreement;

 

		(ix)	it shall obtain and at all times during the Term of this Agreement maintain at its expense, all
licenses, permits and approvals necessary for it to perform its obligations under this Agreement;

 

		(x)	it is not currently subject to any proceeding which is pending or, to its knowledge, threatened,
for reorganization, liquidation or dissolution for the benefit of its creditors or otherwise;

 

		(xi)	[123I]NAV5001 shall not be misbranded within the meaning of the FD&C as a result
of the proper application of the label content supplied by Navidea to Nordion pursuant to this Agreement, and [123I]NAV5001
is not an article which may not be introduced into interstate commerce under the provisions of section 505 of the FD&C.

 

ARTICLE 12 – NORDION’S
REPRESENTATIONS AND WARRANTIES

 

		12.1	Representations and Warranties

 

Nordion represents and warrants
that:

 

		(i)	it is duly organized, validly existing and in good standing under the laws of the jurisdiction
of its organization;

 

		(ii)	it has full right and authority to enter into this Agreement;

 

		(iii)	it is the owner or has the right to use the Nordion Background Technology and other Nordion proprietary
technology to be used, or necessary for Nordion to perform its obligations under this Agreement, during the Term of this Agreement;

 

		(iv)	to Nordion's knowledge, Manufacturing [123I]NAV5001 and the Nordion Background Technology
used in carrying out its activities under this Agreement do not infringe any valid third party patent or other intellectual property
right of any third party;

 

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		(v)	it has not received any notice
                                                               of adverse claim or infringement of any patent or other intellectual
                                                               property right, or of misappropriation of trade secrets, in connection
                                                               with the use and exploitation of the Nordion Background Technology
                                                               related to its activities under this Agreement;

 

		(vi)	there is no action or proceeding
                                                                pending or, to its knowledge, threatened against Nordion before
                                                                any court, administrative agency or other tribunal which would
                                                                have an adverse material effect on Nordion’s ability to
                                                                perform its obligations hereunder;

 

		(vii)	Nordion is not currently subject
                                                                 to any proceeding which is pending or, to its knowledge, threatened,
                                                                 for reorganization, liquidation or dissolution for the benefit
                                                                 of its creditors or otherwise;

 

		(viii)	it shall obtain and at all times
                                                                  during the Term of this Agreement maintain, at its expense,
                                                                  all licenses, permits and approvals necessary for it to carry
                                                                  out its activities and obligations under this Agreement;

 

		(ix)	it is not under any obligations,
                                                                contractual or otherwise, to any other entity that might conflict,
                                                                interfere or be inconsistent with the execution, delivery or any
                                                                of the provisions of this Agreement;

 

		(x)	[123I]NAV5001 delivered
                                                               pursuant to this Agreement shall, at the time of delivery by Nordion
                                                               to Navidea, not be misbranded (to the extent branded by Nordion)
                                                               or adulterated within the meaning of FD&C.

 

ARTICLE 13 – INDEMNITY

 

		13.1	Indemnification by Navidea

 

Navidea agrees to indemnify,
defend and hold Nordion and its Affiliates and their respective directors, officers, employees and agents, representatives, successors,
heirs and permitted assigns harmless from and against any damages, claims, liabilities and expenses (including, but not limited
to, reasonable attorney’s fees) resulting from any third party claims or suits (“General Claims Against Nordion”)
to the extent arising out of: (a) Navidea’s or a third party’s use, handling or shipping of Reference Standards, Precursor
or [123I]NAV5001 (including in the event that Nordion makes shipping arrangements on behalf of Navidea); (b) Navidea’s
breach of any of its obligations, warranties or representations hereunder; (c) Navidea’s, its subcontractors’, agents’
or employees’ negligent acts or omissions or willful misconduct; or (d) failure of the Reference Standards or Precursor
to meet applicable specifications. Notwithstanding anything in this Section 13.1, “General Claims Against Nordion”
shall not include “IP Claims Against Nordion” as described in Section 13.3.

 

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		13.2	Indemnification by Nordion

 

Nordion agrees to indemnify,
defend and hold Navidea and its Affiliates and their respective directors, officers, employees and agents, representatives, successors,
heirs and permitted assigns harmless from and against any damages, claims, liabilities and expenses (including, but not limited
to, reasonable attorney’s fees) resulting from any third party claims or suits (“General Claims Against Navidea”)
to the extent arising out of: (a) Nordion’s Manufacture (except to the extent arising out of any portion of the Process,
labels and/or content thereof which was provided by Navidea) or preparation for shipment of [123I]NAV5001; (b) Nordion’s
breach of any of its obligations, warranties or representations hereunder; (c) Nordion’s, its subcontractors’, agents’
or employees’ negligent acts or omissions or willful misconduct; or (d) any failure of the [123I]NAV5001 to meet
the Specifications. Notwithstanding anything in this Section 13.2, “General Claims Against Navidea” shall not include
“IP Claims Against Navidea” as described in Section 13.4.

 

		13.3	Intellectual Property Claims Against Nordion

 

Navidea agrees to indemnify,
defend and hold Nordion and its Affiliates and their respective directors, officers, employees, agents, representatives, successors,
heirs and permitted assigns harmless from and against any damages, claims, liabilities and expenses (including, but not limited
to, reasonable attorneys’ fees) resulting from any third party claims or suits arising out of any proceeding instituted
by or on behalf of a third party based upon a claim that Navidea Background Technology, the Process (to the extent contributed
by Navidea), or the use or sale of the Reference Standards, Precursors or [123I]NAV5001 infringes a patent or any other
intellectual property right of a third party (“IP Claim Against Nordion”).

 

		13.4	Intellectual Property Claims Against Navidea

 

Nordion agrees to indemnify,
defend and hold Navidea and its Affiliates, and their respective directors, officers, employees, agents, representatives, successors,
heirs and permitted assigns harmless from and against any damages, claims, liabilities and expenses (including, but not limited
to, reasonable attorney’s fees) resulting from any third party claims or suits arising out of
any proceeding instituted by or on behalf of a third party based upon a claim that the Nordion Background Technology, the method
of Manufacture of [123I]NAV5001, or the Process (to the extent developed or contributed by Nordion) infringes a patent
or any other intellectual property right of a third party (“IP Claim Against Navidea”). 

 

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		13.5	Obligations of Nordion With Respect to Infringement
Claims

 

In the event that any portion
of the Nordion Background Technology, required in the Manufacture of [123I]NAV5001, in the opinion of independent counsel
mutually selected by the parties, becomes the subject of a valid claim for a patent, copyright or other intellectual property
right infringement then Nordion shall for a period of at least sixty (60) days after issuance of the opinion, use its Commercially
Reasonable Efforts to:

 

		i)	procure the right to continue using
                                                              the technology or method of Manufacture,

 

		ii)	modify the Nordion Background Technology,
                                                               method of Manufacture to become non-infringing (with all Nordion
                                                               costs, including any commercially reasonable increase to the cost
                                                               of the manufacturing of [123I]NAV5001 to be borne by
                                                               Nordion)

 

		iii)	obtain an opinion of independent
                                                                counsel mutually selected by the parties that the claim or allegation
                                                                of infringement is not valid.

 

If Nordion is unable to resolve
the claim or allegation of infringement on commercially reasonable terms in accordance with subparagraph i), ii) or iii) above
within 90 days, Navidea or Nordion, may upon written notice, suspend the Manufacture of [123I]NAV5001 and/or terminate
this Agreement. The provisions of this Section 13.5 are in addition to, and do not in any way limit, the indemnification obligations
of Nordion set forth in this Article 13.

 

		13.6	Obligations of Navidea With Respect to Infringement
Claims

 

In the event [123I]NAV5001,
that any portion of the Navidea Background Technology required in the Manufacture of [123I]NAV5001, in the opinion
of independent counsel mutually selected by the parties or the Process (to the extent contributed by Navidea), becomes the subject
of a valid claim for a patent, copyright or other intellectual property right infringement, then Navidea shall for a period of
at least sixty (60) days after issuance of the opinion, use its Commercially Reasonable Efforts to:

 

		i)	procure the right to continue using
                                                              the technology,

 

		ii)	modify the Navidea Background Technology
                                                               to become non-infringing provided such modification does not increase
                                                               the cost of Manufacture of [123I]NAV5001 by Nordion
                                                               (with all Navidea’s costs including any increase to the cost
                                                               of the Manufacture of [123I]NAV5001 by Nordion to be
                                                               borne by Navidea)

 

		iii)	obtain an opinion of independent
                                                                counsel mutually selected by the parties that the claim or allegation
                                                                of infringement is not valid.

 

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If Navidea is unable to resolve
the claim or allegation of infringement on commercially reasonable terms in accordance with subparagraph i), ii) or iii) above
within 90 days, Nordion or Navidea may upon written notice, suspend Manufacture activities and/or terminate this Agreement. The
provisions of this Section 13.6 are in addition to, and do not in any way limit, the indemnification obligations of Navidea set
forth in this Article 13.

 

		13.7	Indemnification Procedures

 

A
party (the “Indemnitee”) intending to claim indemnification under this Agreement shall promptly notify the
other party (the “Indemnitor”) in writing of any action, claim or other matter in respect of which the Indemnitee
or any of its directors, officers, employees or agents intend to claim such indemnification; provided, however, the failure
to provide such notice within a reasonable period of time shall not relieve the Indemnitor of any of its obligations hereunder
except to the extent the Indemnitor is materially prejudiced by such failure. The Indemnitor shall be entitled to control the
defense of and/or settle any such action, claim or other matter. The Indemnitee agrees to the complete control of such defense
or settlement by the Indemnitor, provided, however, any settlement of such claims shall require the Indemnitee’s prior written
consent unless such settlement includes a full release of the Indemnitee, in which case no consent shall be required. The Indemnitee
and its directors, officers, employees and agents shall co-operate fully with the Indemnitor and its legal representatives in
the investigation and defense of any action, claim or other matter covered by this indemnification. The Indemnitee shall have
the right, but not the obligation, to be represented by counsel of its own selection and at its own expense.

 

ARTICLE 14 –
REGULATORY MATTERS

 

		14.1	Navidea Responsibilities

 

It shall be the responsibility
of Navidea or its designee to file, obtain and maintain an IND/NDA, registrations, listings, authorizations and approvals as the
FDA or any other applicable governmental entity may require to enable use of [123I]NAV5001 in Clinical Trials in the
United States and Canada. Navidea will be responsible for any FDA and Health Canada fees specifically related to Clinical Trials
of [123I]NAV5001. Nordion shall provide directly to Navidea, or at Nordion’s discretion for the purpose of protection
of its proprietary technology with respect to the manufacture of the Isotope, directly to the regulatory authority (with a copy
to Navidea purged of Nordion proprietary technology) all required information in its possession necessary to assist Navidea in
filing, obtaining and maintaining all licenses, registrations, listings, authorizations and approvals of any governmental entities
necessary for the use of [123I]NAV5001 in support of Navidea’s [123I]NAV5001 IND/NDA submission. Navidea
will provide Nordion with copies of any submissions made describing activities that occur at Nordion.

 

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		14.2	Nordion Responsibilities

 

Nordion shall be responsible
for obtaining and maintaining, at its sole expense, all necessary facility licenses, registrations, authorizations and approvals
which are necessary to Manufacture, prepare for shipment, and export [123I]NAV5001 in accordance with cGMPs, the Master
Batch Record and the Quality Agreement and other regulatory requirements including, but not limited to, the use and handling of
radioactive materials.

 

At Nordion’s expense,
Nordion shall update and maintain its existing I-123 bulk chemical Drug Master File (“DMF”) with the FDA as
may be required for Navidea’s IND/NDA for [123I]NAV5001. Nordion hereby grants Navidea for the purpose of this
Agreement, a right of reference to such DMF and upon request shall provide a letter of access to the DMF allowing regulatory review
of the DMF by the FDA in conjunction with Navidea’s [123I]NAV5001 submissions.

 

		14.3	Government Inspections, Compliance Review and Inquiries

 

Upon request of any governmental
entity or any third party entity authorized by a governmental entity, such entity shall, for the purpose of regulatory review
and compliance, have access to observe and inspect the: (i) Facility; (ii) procedures used for the storage of Reference Standards
and Precursor; and (iii) manufacturing, testing, storage and preparation for shipment of [123I]NAV5001, including Process
development operations, and auditing the Facility for compliance with cGMP and/or other applicable regulatory standards. Nordion
shall give Navidea prompt written notice of any upcoming inspections or audits by a governmental entity of the Facility or any
of the foregoing, shall allow Navidea to participate in such inspections by being present at any such FDA close-out meetings and
shall provide Navidea with a written summary of such inspection within five (5) business days following completion thereof. Nordion
agrees to use Commercially Reasonable Efforts to promptly rectify or resolve any deficiencies noted by a government entity in
a report or correspondence issued to Nordion or Navidea. Subject to any specific arrangements agreed upon by the parties, Navidea
shall be responsible for communicating with any governmental authority concerning [123I]NAV5001 or the marketing, distribution,
sale or clinical use of [123I]NAV5001, and Nordion shall, in accordance with the compensation rates set forth in Section
3.5 provide Navidea with whatever assistance Navidea may reasonably require to assist it in such communications. Nordion shall
have no such communications specifically related to [123I]NAV5001, except to the extent (and notwithstanding its confidentiality
undertakings in this Agreement) that they relate to Nordion’s Manufacture of [123I]NAV5001 under this Agreement
or as required of Nordion directly by the governmental or regulatory authority, in which case Nordion shall be responsible for
such communications. Notwithstanding the foregoing and except to the extent that an immediate or urgent communication is necessary
under the circumstances or required by law, Nordion in good faith shall consult in advance with Navidea regarding all communications
that relate to [123I]NAV5001 or to Nordion’s ability to Manufacture [123I]NAV5001 pursuant to this
Agreement.

 

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		14.4	Complaints
and Adverse Events

 

Nordion and Navidea shall fully
comply with the terms of the Quality Agreement regarding their respective obligations and responsibilities with respect to any
complaints or adverse events regarding the Precursor, Reference Standards, [123I]NAV5001, Isotope, and other activities
related to this Agreement.

 

		14.5	Recalls

 

Nordion and Navidea shall fully
comply with the terms of the Quality Agreement regarding their respective obligations and responsibilities with respect to any
recall of or corrective action related to the Precursor, Reference Standards or [123I]NAV5001. Navidea shall notify
Nordion promptly if [123I]NAV5001 is the subject of a recall or correction (a “Recall”), and Navidea
and/or its designee shall have sole responsibility for the handling and disposition of such Recall. Navidea and/or its designee
shall bear the costs of any Recall of [123I]NAV5001 unless and to the extent such Recall shall have been the result
of Nordion’s or its agents or employees negligent acts or omissions or any product defects for which Nordion is responsible
in which case Nordion shall to such extent be responsible for all of Navidea’s reasonable out-of-pocket costs incurred for:

 

		(i)	notification of recall to Nordion
                                                               and third parties;

 

		(ii)	return shipment or destruction
                                                                of any defective [123I]NAV5001 to Nordion; and

 

		(iii)	replacement of [123I]NAV5001
                                                                 .

 

In the event that Nordion disputes
Navidea’s determination that the fault is due to Nordion and/or to its employees or agents, the parties will select a mutually
agreeable outside consulting firm which will be instructed to review the applicable information and data and to confirm or dissent
from Navidea’s determination. If the consulting firm confirms Navidea’s determination, Nordion will pay the fees of
such consulting firm. If the consulting firm dissents from Navidea’s determination Nordion will not have the obligations
set forth herein with respect to the Recall and Navidea will pay the fees of such consulting firm. Navidea and/or its designee
shall maintain records of all sales, shipping records of [123I]NAV5001 and customers in sufficient detail to adequately
administer a Recall for the period of time as required by applicable regulation.

 

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		14.6	New Regulatory Requirements

 

Each party shall promptly notify
the other of new regulatory requirements of which it becomes aware which are relevant to the manufacture of NAV5001 under this
Agreement and which are required by the FDA and other applicable governmental entities. The parties shall confer with each other
with respect to the best means to implement and comply with such requirements.

 

If after the Effective Date
any Facility investment above [*] in aggregate is required during any calendar year to comply with any new regulatory requirement
or cGMP mandated by applicable law or a Regulatory Authority, such investment in excess of [*] shall be treated as a scope change
pursuant to Section 3.4 (Schedule G) and paid for by Navidea.

 

		14.7	Records

 

Nordion shall maintain, and
provide Navidea reasonable access to, all records, both during and after the termination of expiration of this Agreement, in accordance
with the Quality Agreement. The cost of any off-site storage of such records after the Term of this Agreement shall be borne by
Navidea and invoiced on a calendar quarter basis. In the event that Navidea fails to cover the cost of storage after the Term
of the Agreement then Nordion may offer to ship the records to Navidea at Navidea’s cost and if Navidea fails to pay such
costs or declines to receive such records, Nordion, in addition to any other remedy available, shall have the right to dispose
of such records as it sees fit.

 

		14.8	Labels

 

Navidea shall be solely responsible
for, and shall provide and approve the form and content of, the labels (except lot number and expiry date which shall be the responsibility
of Nordion) to be applied to [123I]NAV5001. Label form and content (other than lot number and expiry date) shall remain
the liability and exclusive property of Navidea. Such labels shall not be used by Nordion after termination or expiration of this
Agreement and the label provided by Navidea may only be used by Nordion for the purpose of performing its obligations under this
Agreement.

 

		14.9	Testing, Documentation, and Quality Assurance

 

Nordion shall maintain, and
provide Navidea reasonable access to, accurate and complete production records with respect to the Process, Batches and shipments
in accordance with the Quality Agreement.

 

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The
parties agree to execute, and shall comply with their respective obligations and duties set forth in, the Quality Agreement in
substantially the form attached as Schedule “E”.

 

ARTICLE
15 – CONFIDENTIALITY

 

		15.1	Confidentiality and Exceptions

 

During the Term of this Agreement
and thereafter, each party hereto shall maintain in confidence the other party’s Confidential Information and will not use
such information or disclose the content of the transactions contemplated herein to third parties for any purpose other than to
its employees, agents or consultants (which agents or consultants will be bound by a confidentiality agreement incorporating no
less restrictive terms than those set forth herein or that are otherwise reasonably accepted in writing by the other party) with
a need to know such information to perform such party’s obligations under this Agreement as expressly authorized in this
Agreement. This obligation of confidentiality shall not apply to the extent that it can be established by the party in receipt
of such information, that the information:

 

		(i)	was already known to the receiving
                                                               party at the time of disclosure as evidenced by written records
                                                               that existed prior to the party’s receipt of such information;

 

		(ii)	was generally available to the
                                                                public or otherwise part of the public domain at the time of its
                                                                disclosure;

 

		(iii)	became generally available to
                                                                 the public or otherwise part of the public domain after its disclosure
                                                                 to the receiving party through no act or omission of the receiving
                                                                 party;

 

		(iv)	was lawfully disclosed to the
                                                                receiving party by a third party who was not bound to obligations
                                                                restricting disclosure of such information; or

 

		(v)	was independently developed by
                                                               the receiving party without any use of Confidential Information
                                                               of the disclosing party, in whole or in part, as evidenced by written
                                                               records that existed prior to the party’s receipt of such
                                                               information.

 

Each party agrees that it will
take the same degree of care to protect the confidentiality of the other party’s Confidential Information as it takes to
protect its own proprietary and confidential information, which shall in no event be less than a reasonable degree of care. Each
party, and its employees and agents shall protect and keep confidential and shall not use, publish or otherwise disclose to any
third party, except as permitted by this Agreement, or with the other party’s written consent, the other party’s Confidential
Information.

 

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All Confidential Information
supplied by one party to the other to assist in carrying out the obligations hereunder shall remain the property of such party
and shall be returned to the other party upon termination or expiration of this Agreement.

 

ARTICLE 16 – DISCLOSURE OF
INFORMATION

 

		16.1	Authorized Disclosure

Notwithstanding Section 15.1
each party may disclose Confidential Information to the extent such disclosure is necessary for prosecuting or defending litigation
and/or complying with applicable government laws, rules or regulations, provided that if a party is required by law or regulation
to make any such disclosure of the other party’s Confidential Information, except where impracticable for necessary disclosure,
for example in the event of medical emergency, it will give reasonable notice to the other party of such disclosure requirement
prior to making the disclosure. Such prior notice shall be in a form sufficient to allow the other party a reasonable opportunity
to contest or limit any such disclosure. In the event that Confidential Information is required to be disclosed by Navidea or
Nordion pursuant to any applicable law or requirement of a federal, provincial, state or foreign authority, court or administrative
or regulatory body, Navidea or Nordion, as the case may be, shall provide reasonable notice to the other prior to any such disclosure
(and as permitted by applicable law) in order that such party may seek a protective order to preserve the confidentiality of the
Confidential Information prior to its disclosure. The party being required to disclose shall only disclose such portions of Confidential
Information as are strictly required to be disclosed the applicable law or requirement of a federal, provincial, state or foreign
authority, court or administrative or regulatory body, and if permitted by applicable law the other party shall be provided with
the opportunity to review and comment on the disclosure to be made. The party being required to disclose shall not be prevented
from complying with the applicable requirement if the other party does not seek or obtain a protective order or does not provide
its comments on the disclosure promptly.

 

ARTICLE 17 – TERM AND TERMINATION

 

		17.1	Term

 

This Agreement shall commence
upon the Effective Date and, unless terminated earlier pursuant to this Agreement or extended upon mutual agreement of the parties,
shall expire three (3) years after the Effective Date.

 

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		17.2	Termination Without Cause by Navidea

 

Navidea may terminate this Agreement
without cause or penalty upon one hundred and eighty (180) days prior written notice to Nordion. Upon such termination, Nordion
will be entitled to retain all amounts paid by Navidea, and Navidea shall pay to Nordion any undisputed, unpaid amounts due or
earned by Nordion. In the event of such termination without cause by Navidea, for the purpose of clarity Nordion’s obligations
and Navidea's obligations under this Agreement (including but not limited to Sections 4.3 and 4.4) shall continue to apply during
the notice period.

 

		17.3	Termination for Breach

 

This Agreement may be terminated
by a party in the event of breach by the other party of a material term or condition hereof, provided however, the other party
shall first give to the breaching party written notice of the proposed termination of this Agreement (a “Breach Notice”),
specifying the grounds therefore. Upon receipt of such Breach Notice, the breaching party shall have such time as necessary, but
in any event not more than thirty (30) days to cure such breach or fifteen (15) days with respect to a failure by Navidea to pay
any amounts hereunder when due other than with respect to unpaid amounts which Navidea, in good faith, disputes are due to Nordion.
Notwithstanding the foregoing, if the breaching party does not cure such breach within such cure period, the other party may,
upon written notice, terminate the Agreement without prejudice to any other rights or remedies which may be available to such
party.

 

		17.4	Bankruptcy

 

This Agreement may be terminated
by a party in the event the other party files a petition in bankruptcy, is adjudicated a bankrupt, makes an assignment for the
benefit of its creditors, or otherwise seeks relief under or pursuant to any bankruptcy, insolvency or reorganization statute
or proceeding, or if a petition in bankruptcy is filed against it which is not dismissed within sixty (60) days or proceedings
are taken to liquidate the assets of such party (each a “Bankruptcy Event”).

 

		17.5	Remedies upon Termination

 

In the event of termination
or expiration of this Agreement, in addition to any other remedies available to either of the parties:

 

		(i)	Nordion shall use Commercially
                                                               Reasonable Efforts to terminate all activities under this Agreement
                                                               immediately;

 

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		(ii)	within forty-five (45) days of
                                                                such termination, each party, at and pursuant to the request of
                                                                the other, shall destroy (with written certification thereof)
                                                                or deliver to the other the Confidential Information, documentation
                                                                and other information belonging to the other party, retaining
                                                                one archival copy thereof as necessary for compliance with applicable
                                                                laws and regulations and administration of obligations under this
                                                                Agreement;

 

		(iii)	all licenses granted by Navidea
                                                                 to Nordion under this Agreement shall immediately terminate;

 

		(iv)	within sixty (60) days of such
                                                                termination all Precursor and Reference Standards remaining in
                                                                inventory shall, at Navidea’s option and expense (subject
                                                                to a quotation provided by Nordion and payable in advance at the
                                                                request of Nordion), be disposed of or returned by Nordion to
                                                                Navidea;

 

		(v)	upon the termination of this Agreement
                                                               for any reason, except a material breach by Nordion, Navidea shall
                                                               reimburse Nordion for any reasonable expenses incurred in inventory
                                                               write-down, Facility decommissioning and any related waste disposal
                                                               costs and, only for employees specifically hired in support of
                                                               the [123I]NAV5001 program, employee(s) severance as
                                                               a result of or arising from discontinuation of the Manufacture
                                                               of [123I]NAV5001;

 

		(vi)	Navidea shall pay to Nordion any
                                                                undisputed amounts otherwise due within thirty (30) days of the
                                                                date of termination.

 

ARTICLE 18 – SURVIVAL

 

		18.1	Consequences or Termination or Expiration

 

All Sections which by their
nature must survive in order to give effect to their intent and meaning shall survive termination or expiration of this Agreement,
including, without limitation, Articles 8, 10.2, 10.3, 13, 14.4, 14.5, 14.7, 14.8, 15, 16, 17.5, 18, 19, 20, 22.1, 23, 24, 25,
26, 27, 28, and 29.

 

ARTICLE 19 – NOTICES

 

		19.1	Any notice to be sent to a party hereunder shall be
forwarded to:

 

	 	Nordion at:	Nordion (Canada) Inc.
	 	 	447 March Road
	 	 	Ottawa, ON K2K 1X8
	 	Attention:	Vice President, Marketing, Sales and Business Development
	 	 	Fax: 613-592-0767
	 	with copy to :	Senior Vice President and General Counsel
	 	 	 
	 	Navidea at:	Navidea
	 	 	425 Metro Place North, Suite 450

Dublin, OH 43017-1367, USA
	 	Attention:	Chief Executive Officer
	 	 	Fax: 614-793-7520

 

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Any notice required or authorized
to be given by a party to the other in accordance with the provisions of this Agreement shall, unless otherwise specifically stipulated,
be in writing and delivered personally, by a nationally recognized overnight courier, or if by electronic facsimile confirmed
by certified or registered mail. Notice shall be deemed delivered upon receipt.

 

ARTICLE 20 – ASSIGNMENT

 

		20.1	No Assignment

 

This Agreement shall enure to
the benefit of and shall be binding upon the heirs, executors, administrators, successors and permitted assigns of the parties.
Neither Nordion nor Navidea shall assign this Agreement or any portion of this Agreement without the written approval of the other
party, which approval shall not be unreasonably or untimely withheld; provided, however, that either party may assign this Agreement
(including without limitation all of its respective rights and interests in the license granted under section 10.1), upon written
notice and without the other’s consent in connection with the sale of all or substantially all of its assets or the business
to which this Agreement pertains, to a third party (provided such third party has agreed to accept assignment and assume the obligations
and liabilities under this Agreement) or in connection with a merger, consolidation or similar transaction involving such party.

 

ARTICLE 21 – COMPLIANCE

 

		21.1	Compliance with Laws

 

This Agreement and Nordion’s
and Navidea’s obligations hereunder shall be carried out in all material respects in compliance with all applicable laws,
by-laws, rules, regulations and orders of all applicable Federal, State, Provincial and Municipal governments. Navidea agrees
to comply with all applicable export and import control laws. Nordion shall be responsible for all export licenses, authorizations
and other customs formalities necessary for the export of [123I]NAV5001 from Canada. Navidea acknowledges and agrees
that Nordion may, in its sole discretion and without liability whatsoever to Navidea or any third party, terminate or delay the
supply of product under this Agreement (notwithstanding an accepted order) should Nordion, acting in good faith, have reasonable
grounds to believe: (a) Navidea may have violated or will violate any U.S. import controls legislation or regulations; (b) the
Canadian or other applicable government body or authority or international organization of which Canada is a member or to which
it adheres issues an embargo, sanction or advisory, or other export control or end user restriction; or (c) the delivery destination
or area through which the shipment must pass is unsafe for reasons including, but not limited to, physical or environmental conditions,
war, revolution, civil commotion, acts of terrorism, or acts of public enemies or where government advisories are in effect.

 

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		21.2	Anti-Corruption

 

In performance of this Agreement
Nordion and Navidea and their respective personnel, agents and representatives shall at all times during the Term abide by all
applicable, obligations imposed by the anti-bribery laws and foreign corrupt practices laws of all applicable jurisdictions in
which the services are rendered, or obligations are carried out, and the laws of any other jurisdiction in which Navidea or any
of its personnel, agents or representatives conducts business in relation to dealing with payments to governments or related persons
or officials, or a company, for the purpose of obtaining or retaining business for or with, or directing business to, any person.
For greater certainty, the foregoing laws shall include, among others, the Criminal Code Amendment (Bribery of Foreign Public
Officials) Act 1999 and the Competition and Consumer Act 2010 of Australia, the Foreign Corrupt Practices Act
of the United States of America, the Lobbyists Registration Act (Canada), the Corruption of Foreign Public Officials
Act (Canada), the Bribery Act 2010 (United Kingdom), and the Criminal Code of Canada. The parties agree that
no portion of monies paid, or payable, in connection with its performance of this Agreement shall, directly or indirectly, be
paid, received, transferred, loaned, offered, promised or furnished to or for the use of an officer or employee of any institution,
government department, agency, instrumentality or corporation thereof, or any political party or any official of such party or
candidate for office or any person acting for or on behalf of any of the foregoing, for the purpose of obtaining or retaining
business for, or with, or directing business to, any person.

 

ARTICLE 22 – NON-WAIVER AND
FORCE MAJEURE

 

		22.1	Non-Waiver of Rights

 

Failure by either party to enforce
at any time any of the provisions of this Agreement shall not be construed as a waiver of its rights hereunder. Any waiver of
a breach of any provision hereof shall not be effective unless in writing and shall not affect either party’s rights in
the event of any additional breach.

 

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		22.2	Force Majeure

 

Neither party shall be liable
to the other for failure to perform or delay in performing its obligations under this Agreement by virtue of the occurrence of
an event of Force Majeure. In the event such Force Majeure affecting either party continues for more than ninety (90) days the
party not subject of the Force Majeure may, upon thirty (30) days written notice, terminate this Agreement. “Force Majeure”
shall mean an occurrence arising from unforeseen circumstances beyond a party’s reasonable control which prevents, delays
or interferes with the performance by such party of any of its obligations hereunder including without limitation an event that
occurs by reason of any act of God, flood, power failure, fire, explosion, casualty or accident, failure, inability or incapacity
of suppliers or usual suppliers to have available for supply sufficient raw materials, equipment or machinery, or war, revolution,
civil commotion, acts of public enemies, act of terrorism, blockage or embargo, interruption of or delay in transportation, strike
or labor disruption.

 

In the event of Force Majeure,
the party affected shall promptly notify the other party and shall exert Commercially Reasonable Efforts to eliminate, cure or
overcome such event and to resume performance of its obligations.

 

In the event that such Force
Majeure affects Isotope, Nordion shall use Commercially Reasonable Efforts to identify a then-existing alternative source of Isotope
supply. Any incremental cost incurred by Nordion subsequent to entering into this Agreement in obtaining Isotope from a then existing
alternative supplier for Manufacture of [123I]NAV5001, shall be borne on a pass-through basis by Navidea. All costs
and expenses, including, but not limited to, qualifying and validating an existing alternative supplier of Isotope for use in
the Process shall be borne by Navidea. If Navidea elects not to bear the incremental cost, Manufacture of [123I]NAV5001
shall be suspended during the period of Force Majeure, without liability to either party.

 

ARTICLE 23 – INSURANCE 

 

		23.1	Nordion Insurance

 

Without limiting any other obligation
or liability hereunder, Nordion, at its expense, during the Term of this Agreement, shall obtain and maintain insurance coverage
with limits and conditions not less than those specified below:

 

		(i)	Commercial General Liability insurance
                                                               (including product liability insurance) with a per-occurrence limit
                                                               of not less than [*];

 

		(ii)	Workers’ Compensation insurance
                                                                in accordance with the statutory limits and requirements of the
                                                                Province of British Columbia, Canada.

 

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In the event that the above
described insurance policies are written on a claims-made basis, then such policies shall be maintained during the Term and for
a period of not less than two (2) years thereafter. The insurance limits shall be in Canadian dollars or equivalent.

 

Navidea shall be named as additional
insured under the Commercial General Liability insurance policy. Upon request, Nordion agrees to provide a Certificate of Insurance
to Navidea evidencing the aforementioned insurance required and Navidea's additional insured status. Nordion will not be deemed
to be relieved of any liability or responsibility because of the fact that it maintains (or does not maintain) insurance. The
certificate(s) will also state that Nordion’s insurer will endeavor to provide Navidea thirty (30) days written notice prior
to any cancellation or the policy’s expiration date. The Commercial General Liability insurance required under this Agreement
shall be obtained from an insurance carrier with an A.M. Best rating of at least A-.

 

		23.2	Navidea Insurance

 

Without limiting any other obligation
or liability of Navidea, under this Agreement, Navidea agrees that during the Term of this Agreement, Navidea shall obtain and
maintain insurance coverage with limits and conditions not less than those specified below:

 

		(i)	Commercial General Liability insurance
                                                               (excluding products liability insurance) with a per-occurrence
                                                               limit of not less than [*] and a commercial umbrella policy with
                                                               a per-occurrence limit of not less than [*];

 

		(ii)	Products liability insurance with
                                                                a per-occurrence limit of not less than [*];

 

		(iii)	Workers’ Compensation insurance
                                                                 with statutory limits per state of hire, and Employers Liability
                                                                 Insurance with limits of a minimum of [*] per accident.

 

In the event that any of the
above described insurance policies are written on a claims-made basis, then such policy (ies) shall be maintained during the Term
of this Agreement and for a period of not less than two (2) years thereafter.

 

Nordion shall be named as an
additional insured under each of the Commercial General Liability, Products Liability and Commercial Umbrella policy. Upon request,
Navidea agrees to provide a Certificate of Insurance to Nordion evidencing the aforementioned insurance required and Nordion’s
additional insured status. Navidea will endeavor to provide Nordion thirty (30) days written notice of any cancellation prior
to the policy’s expiration date. During the Term of the contract, Navidea will maintain property insurance, to insure the
physical loss of its inventory and list the Nordion site as an insured location. Each insurance policy which is required under
this Agreement shall be obtained from an insurance carrier with an A.M. Best rating of at least A-.

 

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ARTICLE 24 – PUBLICATION

 

		24.1	Publicity

 

The parties agree that, except
as may otherwise be set out in this Agreement or be required by applicable laws, regulations, rules or orders or in connection
with obtaining regulatory approvals for [123I]NAV5001, no information concerning this Agreement and the transactions
contemplated herein shall be made public by either party without the prior written consent of the other, which consent shall not
be unreasonably withheld or delayed. In the event either party decides to issue a press release announcing the execution of this
Agreement, it shall not do so without the prior written approval of the other party, which shall not be unreasonably withheld.

 

A copy of any proposed press
release shall be provided to the other party for approval at least ten (10) business days prior to any proposed release.

 

In the event that this Agreement
or any portion of its contents is required to be disclosed by Navidea or Nordion pursuant to Security Exchange Commission rules
or regulations, the FDA, or other federal or state authorities, Navidea or Nordion, as the case may be, shall provide reasonable
notice to the other prior to any such disclosure in order that, to the extent possible (and as permitted by applicable law) permitting
such party to redact this Agreement of sensitive or confidential information while enabling the other party to comply with the
applicable laws, rules and regulations.

 

ARTICLE 25 – INDEPENDENT
CONTRACTOR

 

		25.1	No Joint Venture

 

The parties agree that with
respect to the transactions contemplated herein that they shall both be acting as independent contractors and nothing herein shall
constitute or create a joint venture, partnership or employer-employee relationship, nor shall anything herein constitute either
party as an agent, representative or distributor of the other for any purpose whatsoever.

 

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ARTICLE 26 – SEVERABILITY

 

		26.1	Invalid Provisions

 

If any provision or term of
this Agreement is found unenforceable under any of the laws or regulations applicable thereto, all other conditions and provisions
of this Agreement shall nevertheless remain in full force and effect. Upon such determination that any term or other provision
is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this Agreement
to effect the original intent of the parties as closely as possible in a mutually acceptable manner, in order that the transaction
contemplated hereby be consummated as originally contemplated to the greatest extent possible.

 

ARTICLE 27 – AGREEMENT

 

		27.1	Entire Agreement

 

This Agreement, including the
Schedules hereto which are incorporated herein, constitute the entire agreement of the parties with respect to the subject matter
hereof and supersedes all proposals, oral or written, and all negotiations, conversations, or discussions. This Agreement may
not be modified, amended, rescinded, canceled or waived, in whole or in part, except by written amendment signed by both parties
hereto. In the event of a conflict between a term of this Agreement and any Schedule or Quality Agreement, the terms of this Agreement
shall govern. The captions or headings herein are solely for convenience and have no effect on the meaning or interpretation of
this Agreement.

 

ARTICLE 28 – DISPUTE RESOLUTION

 

		28.1	Except as otherwise set out or provided
                                                            for in this Agreement, in the event that at any time during the Term
                                                            of this Agreement, a disagreement, dispute, controversy or claim should
                                                            arise with respect to the interpretation or application of this Agreement,
                                                            the parties will attempt, in good faith, to resolve their difference
                                                            for a period of ten (10) days following written notice from one party
                                                            to the other specifying such disputes. In the event the parties are
                                                            unable to agree on the resolution of the dispute during such ten (10)
                                                            day period or any extension thereof that the parties agree to in writing,
                                                            either party will be free to take any action and seek any remedy it
                                                            may have, in law or in equity, including specific performance and
                                                            injunctive relief. Notwithstanding the foregoing, either party may
                                                            take any action and seek any remedy it may have, in law or in equity,
                                                            without having fully complied with the above dispute resolution process,
                                                            in order to avoid expiration of any applicable statute of limitations
                                                            or as otherwise necessary to prevent irreparable harm.

 

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ARTICLE 29 – LAW

 

		29.1	Applicable Law

 

This Agreement shall be governed
and construed in accordance with the laws of the Province of Ontario, Canada, without reference to its principles on conflict
of laws. The application of the United Nations Convention on Contracts for the International Sale of Goods is expressly excluded.

 

ARTICLE 30 – EXECUTION

 

		30.1	This Agreement may be executed in
                                                            two or more counterparts, each of which together shall be deemed an
                                                            original, but all of which together shall constitute one and the same
                                                            instrument. In the event that any signature is delivered by facsimile
                                                            transmission or by e-mail delivery of a “.pdf” format
                                                            data file, such signature shall create a valid and binding obligation
                                                            of the party executing (or on whose behalf such signature is executed)
                                                            with the same force and effect as if such facsimile or “.pdf”
                                                            signature page were an original thereof.

 

[SIGNATURE PAGE FOLLOWS]

 

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IN WITNESS WHEREOF the parties hereto
have executed this Agreement as of the date first above written.

 

	NORDION (CANADA) INC.	 	NAVIDEA BIOPHARMACEUTICALS, INC.
	 	 	 
	/s/ Scott McIntosh 	 	/s/ Mark J. Pykett
	Nordion Representative (Signature)	 	Navidea Representative (Signature)
	 	 	 
	Scott McIntosh 	 	Mark J. Pykett
	Name	 	Name
	 	 	 
	Chief Operating Officer,
    Specialty Isotopes & General Manager, Sterilization Technologies	 	Chief Executive Officer
	Title	 	Title
	 	 	 
	May 10, 2013	 	May 10, 2013
	Date	 	Date

 

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SCHEDULE A

 

Facility
Program, Facility Milestones and Project Schedule

 

The Facility Program outlined in this
Schedule A provides for the return to operation of the Facility for the Manufacture of [123I]NAV5001 for Navidea clinical
studies in accordance with the project schedule outlined below and further set out in Table 1. There are 4 major milestones that
must be satisfied pursuant to the [123I]NAV5001 Clinical Supply Agreement ("Agreement") of which this Schedule
A is a part. Table 1 describes the tasks entailed in more detail, the time necessary to accomplish those tasks, and the dates
to complete each milestone. The finish dates of the tasks and the entire schedule is subject to the start date.

 

Milestone 1- Facility Ready

Description

[*]

Deliverables

		·	[*]

 

Milestone
2 – [*]

Description 

[*]

 

Deliverables:

		·	[*]

 

Milestone 3 – First Validation Run

Description

[*] 

 

Deliverables:

		·	[*]

 

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Milestone 4 – Ready for Clinical Supply

Description

[*] 

 

Deliverables:

 

		·	[*]

 

Facility
resources for Manufacturing [123I]NAV5001

 

In the clinical
supply room (112B) the following Equipment is dedicated to [123I]NAV5001

		·	[*]

		·	[*]

		·	[*]

		o	[*]

		o	[*]:

		§	(1)
                                                                                                                              [*]

		§	(1)
                                                                                                                              [*]

		§	(1)
                                                                                                                              [*]

		§	(1)
                                                                                                                              [*]

		§	(2)
                                                                                                                              [*]

		§	(1)
                                                                                                                              [*]

 

		o	[*]

		o	[*]:

		§	(1)
                                                                                                                              [*]

		o	[*]

		o	[*]

		o	[*]

		·	[*].

 

The general features of room 112B are:

		·	[*]

		·	[*]

		·	[*]

 

Other equipment (not in clinical supply
room) dedicated for the manufacture of [123I]NAV5001:

		·	[*]

		o	(1)
                                                                                                                               [*]

		o	(1)
                                                                                                                               [*]

		o	(1)
                                                                                                                               [*]

		o	(1)
                                                                                                                               [*]

 

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Non-dedicated support services used for
the Manufacturing of [123I]NAV5001:

 

		·	[*]

		·	[*]

		·	[*]

		·	[*]

		·	[*]

		·	[*]

 

[*]

 

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Table 1.

Program Schedule

 

	ID	 	Task
    Name	 	Duration	 	Start	 	Finish	 	Predecessors
	1	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	2	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	3	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	4	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	5	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	6	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	7	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	8	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	9	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	10	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	11	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	12	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	13	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	14	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	15	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	16	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	17	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	18	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	19	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	20	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	21	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	22	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	23	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	24	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	25	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	26	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	27	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	28	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	29	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	30	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	31	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	32	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	33	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	34	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	35	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	36	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	37	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	38	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	39	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	40	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	41	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	42	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	43	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	44	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	45	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	46	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	47	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	48	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	49	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	50	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	51	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	52	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	53	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	54	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	55	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	56	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	57	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	58	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	59	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	60	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	61	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	62	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	63	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	64	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	65	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	66	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	67	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	68	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	69	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	70	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	71	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	72	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	73	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	74	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	75	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	76	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	77	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	78	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]

 

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 SCHEDULE B

 

[123I]NAV5001 Specifications

 

	 	 	Specifications
	Animal products	 	[*]
	 	 	[*]
	Formulation	 	[*]
	 	 	[*]
	Primary Packaging	 	[*]
	 	 	[*]
	Calibration time	 	[*]
	 	 	[*]
	Doses per vial	 	[*]
	 	 	[*]
	Maximum volume	 	[*]
	 	 	[*]
	Sterilization process	 	[*]
	 	 	[*]
	Final Product Release	 	[*]
	Visual Inspection	 	[*]
	pH	 	[*]
	Activity Concentration	 	[*]
	Total Activity	 	[*]
	Radionuclidic Identity	 	[*]
	Radionuclidic Purity	 	[*]
	Radiochemical Identity	 	[*]
	Radiochemical Purity	 	[*]
	Chemical Purity	 	[*]
	Endotoxin	 	[*]
	Sterility	 	[*]

 

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SCHEDULE C

 

Fees for Facility Program and return to operation of the
Facility for Clinical Trials’ supply of [123I]NAV5001 

 

	Payment
    Milestones 	 	Initial

    Payment 	 	Milestone

    1	 	Milestone

    2	 	Milestone

    3	 	Milestone

    4	 	Total
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]
	 	 	 	 	 	 	 	 	 	 	 	 	 
	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]	 	[*]

 

Notes:

 

		1)	Navidea will pay to Nordion for the
                                                             services set forth in this Agreement plus all applicable taxes on
                                                             the amounts mentioned above.

 

		2)	The scope excludes any travel by
                                                             Nordion employees.

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SCHEDULE D 

 

Batch Fees

 

[123I]NAV5001 Batch Fees 

 

		A.	[*]

 

		B.	[*]

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 SCHEDULE E

 

INTERCOMPANY QUALITY AGREEMENT

 

Navidea Biopharmaceuticals, Inc.

425 Metro Place North, Suite 450

Dublin, OH 43017-1367, USA

(hereafter called “Navidea”)

 

AND

 

Nordion (Canada) Inc.

447 March Road

Ottawa, Ontario, Canada K2K 1X8

(hereafter called “Nordion”)

 

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Quality Assurance Agreement (QAA)

[123I]NAV5001
Drug Product Manufacture by

Nordion (Canada) Inc.

 

QAA-009 Revision A

 

Table of Contents

 

	1	Purpose	49
	2	Scope	49
	3	Procedures for amendments	49
	4	Term / Termination of Agreement	49
	5	Survival Clause	49

 

List
of Appendices

 

	Appendix 1.	Responsibility Delegation checklist	50
	Appendix 2.	Change History	56
	Appendix 3.	Key Contacts	57
	Appendix 4.	Signature Page	58

 

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Purpose

 

This Quality Assurance Agreement (QAA) defines the activities
and responsibilities between the two parties, Nordion (Canada) Inc. (“NORDION”) and Navidea Biopharmaceuticals Inc.
(“NAVIDEA”) with respect to the [123I]NAV5001 drug product manufacture.

 

Scope

 

This QAA includes the activities associated with the production,
handling, analysis, release, warehousing, and distribution of [123I]NAV5001. This agreement is subject to the terms
of a Clinical Supply Agreement (CSA) between NORDION and NAVIDEA that defines the specific business terms upon which NORDION is
providing services to NAVIDEA. The respective parties also agree to perform the activities identified herein. In the case of discrepancy
between this QAA and the [123I]NAV5001 Clinical Supply Agreement, the [123I]NAV5001 Clinical Supply Agreement
shall prevail.

 

Procedures
for amendments

 

This QAA may be amended from time to time in writing by the
mutual written consent of both parties. Amendments to the QAA are routed to Quality at NORDION and NAVIDEA for review and approval,
and to ensure compliance with the Regulatory File (IND, NDA, MAA, etc.). The periodic updating of Appendix 3, Key Contacts, does
not constitute a formal revision to the document and therefore does not need written approval.

 

Term
/ Termination of Agreement

 

The term of this QAA shall begin on the date of the last approval
signature (the “Approval Date”) and will expire on the latter of (i) the date of expiration of the CSA or (ii) three
(3) years from the QAA Approval Date, except as noted below in the survival clause.

 

Survival
Clause

 

The provisions under sections Regulatory Authorizations
and GMP Compliance, Testing and Analysis, Record Retention, and Complaints and Adverse Events shall survive
termination of this QAA as required by any applicable government agency.

 

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Appendix 1. Responsibility
Delegation checklist

 

	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	 	 	 	 	 	 	 
	1.   Production	 	 	 	 	 	 
	 	 	 	 	 	 	 
	1.1.	 	Production of [123I]NAV5001 will be in compliance
    with Federal, State, and Local laws and regulations and guidelines for pharmaceutical manufacturing, the Regulatory File,
    and NAVIDEA approved specifications. This will include compliance with regional Good Manufacturing Practices (GMP) (e.g.,
    21 CFR Parts 210 and 211 etc.).	 	 	 	X
	 	 	 	 	 	 	 
	1.2.	 	Automated systems, electronic, signatures and electronic records
    will comply with 21 CFR Part 11 requirements.	 	 	 	X
	 	 	 	 	 	 	 
	1.3.	 	NAVIDEA QA will audit and assess level of compliance in periodic
    audits.	 	X	 	 
	 	 	 	 	 	 	 
	1.4.	 	NAVIDEA CMC will provide NORDION with production/technical information
    that includes specialized equipment required for manufacturing [123I]NAV5001.	 	X	 	 
	 	 	 	 	 	 	 
	1.5.	 	Provide NORDION with copies of those portions of the Regulatory
    File and any subsequent amendments that are applicable to the manufacturing of [123I]NAV5001 at NORD.	 	X	 	 
	 	 	 	 	 	 	 
	1.6.	 	NORDION will establish and maintain a Master Batch Record (MBR),
    and manufacture and test the product in accordance with the NAVIDEA approved MBR and specifications.	 	 	 	X
	 	 	 	 	 	 	 
	1.7.	 	NORDION will establish labeling and packaging requirements in
    accordance with the Regulatory File.	 	 	 	X
	 	 	 	 	 	 	 
	1.8.	 	Upon request NORD, and under the terms of the [123I]NAV5001
    Clinical supply agreement, will allow a NAVIDEA representative to be on site during the manufacture of a batch, but is not
    allowed in the ‘suite’ during the production process.  	 	 	 	X

 

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	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	1.9.	 	Promptly notify NAVIDEA QA and document, investigate,
    and resolve non-conformance, OOS, and deviations from the MBR and/or NAVIDEA approved specifications. These activities will
    be remediated between NAVIDEA and NORDION prior to final disposition of the batch. 	 	X	 	X
	 	 	 	 	 	 	 
	1.10.	 	Conduct an annual review of batches. Evaluate and assess whether
    corrective actions or revalidations should be undertaken.  Submit the approved annual review to NAVIDEA.	 	 	 	X
	 	 	 	 	 	 	 
	1.11.	 	NAVIDEA will promptly notify NORDION if there is a change to
    the specifications submitted to the Regulatory File.	 	X	 	 
	 	 	 	 	 	 	 
	2.      Testing
    and Analysis
	 
	2.1.	 	Where applicable, transfer a copy of the validated analytical
    test method(s) to NORDION.	 	X	 	 
	 	 	 	 	 	 	 
	2.2.	 	Test product according to NAVIDEA approved specifications, analytical
    and microbial test methods and procedures. Provide a copy of the Product Release Form (PRF) to NAVIDEA.	 	 	 	X
	 	 	 	 	 	 	 
	2.3.	 	Conduct sampling in accordance with approved specifications
    within the batch record.	 	 	 	X
	 	 	 	 	 	 	 
	2.4.	 	Within two (2) business days inform NAVIDEA QA of and assist
    in investigating OOS results identified in any testing conducted by NORDION or an independent lab contracted by NORDION and
    provide documentation relating to such investigation with the batch record applicable to the batch containing the OOS test
    result.	 	 	 	X
	 	 	 	 	 	 	 
	2.5.	 	Complete investigations according to the requirements, including
    timeliness, in the standard operating procedures. Non-conforming product will be placed on QA Hold until such non-conformance
    is adequately resolved by completing OOS investigations and reviewing planned deviations.	 	X	 	X
	 	 	 	 	 	 	 
	2.6.	 	Promptly inform NORDION of and investigate OOS results identified
    in any testing conducted by a NAVIDEA designated lab. Promptly provide NORDION copies of documentation relating to such investigations
    for inclusion with the batch record applicable to the batch containing the OOS test result. 	 	X	 	 

 

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	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	2.7.	 	Within two (2) business days notify NORDION of any
    recall and/or confirmed stability failure (if applicable).	 	X	 	 
	 	 	 	 	 	 	 
	3.      Batch
    Record Review and Release
	 
	3.1.	 	NORDION QA will review and approve the PBR to confirm
        compliance with:

        ·     Specifications,

        ·     Regulatory
        File,

        ·     Applicable
        laws, and

        ·     Acceptance
        criteria requirements
	 	 	 	X
	 	 	 	 	 	 	 
	3.2.	 	Product Release Forms (PRFs) will be provided to confirm that
    lots of [123I]NAV5001 were manufactured, packaged and tested in accordance with cGMP.  The PRF will identify
    the master batch record documents, and list any incident reports and investigations associated with the batch.  The
    PRF will present a recording of the results of testing against the established specifications and the signature and date of
    the NORDION QA representative who released the batch.  	 	 	 	X
	 	 	 	 	 	 	 
	3.3.	 	Perform necessary studies to qualify shipping procedures for
    the product.	 	X	 	 
	 	 	 	 	 	 	 
	3.4.	 	Provide specifications for the shipment of product.  Such
    instructions shall include, when appropriate, packaging, labeling, temperature and humidity controls, including methods to
    monitor these conditions.	 	X	 	 
	 	 	 	 	 	 	 
	3.5.	 	Ensure product is stored, handled and shipped to the specified
    destinations in accordance with NAVIDEA instructions.	 	 	 	X
	 	 	 	 	 	 	 
	4.      Regulatory
    Actions and Inspections
	 
	4.1.	 	Notify the other party of any regulatory agency inspection,
    specific to “[123I]NAV5001”, applicable portions of any adverse finding from a regulatory agency within
    two (2) business days of occurrence and any applicable portions of subsequent response(s) to the regulatory agency directly
    related to the product.	 	X	 	X

 

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	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	4.2.	 	Notify the other party of any regulatory agency’s request for samples of product or batch records within two (2) business days of receipt.	 	X	 	X
	 	 	 	 	 	 	 
	4.3.	 	Notify the other party of any requests for information, notices of violations or other communication from a regulatory agency relating to environmental, occupational health (i.e. illness) and safety compliance, within two (2) business days of receipt.	 	X	 	X
	 	 	 	 	 	 	 
	5.      Compliance of Specifications With Regulatory File(s) and Change Control
	 	 	 	 	 	 	 
	5.1.	 	Upon NORDION’s reasonable request, NAVIDEA shall provide updates to Nordion on submissions to the FDA with respect to [123I]NAV5001.	 	X	 	 
	 	 	 	 	 	 	 
	5.2.	 	Provide NAVIDEA with any proposed change that would negatively or positively impact the identity, quality, durability, purity, safety or effectiveness of the Company’s products in writing to NAVIDEA’s QA contact for review and disposition before implementation.	 	 	 	X
	 	 	 	 	 	 	 
	5.3.	 	Ensure that specifications contained in the CSA and MBR comply with the Regulatory File. 	 	X	 	X
	 	 	 	 	 	 	 
	5.4.	 	
        Submit and discuss any proposed changes to the specifications
        to the other party for review and approval, prior to the implementation of such changes and the submission of any such changes
        to the regulatory agency. The exchange of comments between the parties shall occur within fifteen (15) business days.

         

        NAVIDEA shall have final authority over any change to a specification,
        the facilities, processing, or analytical testing that may directly affect the product.
	 	X	 	X
	 	 	 	 	 	 	 
	5.5.	 	Notify NAVIDEA of proposed additions or changes in subcontracted service providers/suppliers that would impact the compliance status of the Regulatory File. 	 	 	 	X
	 	 	 	 	 	 	 
	5.6.	 	Liaison with regulatory authorities for the approval, maintenance and updating of product specifications in the Regulatory File.	 	X	 	(if requested)

  

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	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	6.    Record
    and Sample Retention
	 
	6.1.	 	Maintain the Batch production records and other documentation
        related to the [123I]NAV5001 for the minimum period required by applicable laws, regulations and statutes.

         

        Consistent with NORDION Record Retention SOP, NORDION
        will notify NAVIDEA that records have reached the end of the required retention period and request written authorization
        prior to destruction.

         

        NOTE: Original documents will be maintained at NORDION
        and copies provided to NAVIDEA
	 	X	 	X
	 	 	 	 	 	 	 
	6.2.	 	At termination of the CSA, and once NORDION has fulfilled its regulatory obligation, all
    original records will be shipped to a specified destination for record archival. NAVIDEA will inform the regulatory agency
    of the new records location.	 	X	 	X
	 	 	 	 	 	 	 
	6.3.	 	Consistent with NORDION SOPs, retain (or reserve) samples will be maintained for any Regulatory
    Final Intermediate (NAV5010) and [123I]NAV5001.	 	 	 	X
	 	 	 	 	 	 	 
	6.4.	 	Consistent with NORDION (Sample) Retention SOP, NORDION will notify NAVIDEA that samples
    have reached the end of the required retention period and request written authorization prior to destruction.	 	 	 	X
	 	 	 	 	 	 	 
	7.     Safety
    and Security
	 
	7.1.	 	NAVIDEA CMC will maintain safety, hazard, and handling data on any compound provided on
    Navidea’s behalf and provide a copy of it to NORDION.	 	X	 	 
	 	 	 	 	 	 	 
	7.2.	 	Ensure that access to the facility is through an appropriate security system and that visitors
    must sign in/out and be escorted during any site visit.	 	 	 	X
	 	 	 	 	 	 	 
	8.     Complaints
    and Adverse Events
	 
	8.1.	 	Collect and log information relating to product quality complaints and adverse drug events
    received by either NAVIDEA or NORDION and notify the other party within 2 business days of receipt. 	 	X	 	X

 

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	SECTION	 	RESPONSIBILITIES	 	NAVIDEA	 	NORDION
	8.2.	 	Respond to regulatory agencies regarding product
    complaints and adverse drug events and file the necessary reports.	 	X	 	 
	 	 	 	 	 	 	 
	8.3.	 	NORDION and NAVIDEA shall provide to each other notice either
    of them receives regarding the safety of the Precursor, Reference Standards or [123I]NAV5001, including information
    regarding any confirmed or unconfirmed adverse events  within two (2) business days.	 	X	 	X
	 	 	 	 	 	 	 
	9.     Product
    Recall and Withdrawal
	 
	9.1.	 	NAVIDEA is responsible for the decision to initiate a product
    recall or withdrawal.  	 	X	 	 
	 	 	 	 	 	 	 
	9.2.	 	NAVIDEA is responsible to provide notification of the recall
    to third parties and to NORDION.  NORDION must be informed of the decision to recall within two (2) business days.	 	X	 	 
	 	 	 	 	 	 	 
	9.3.	 	Provide support to NAVIDEA, upon request, to facilitate a product
    recall. 	 	 	 	X
	 	 	 	 	 	 	 
	9.4.	 	Responsible for final reconciliation of returned product following
    product recall or withdrawal.	 	X	 	X
	 	 	 	 	 	 	 
	10.   Quality
    Agreement
	 
	10.1.	 	Review this quality agreement annually and update as necessary.	 	X	 	X

 

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Appendix 2. Change
History

 

	Rev. 	 	 	 	Details	 	 
	Level	 	Rev. Date	 	Page	 	§	 	Description
    of Change
	A	 	15 MAR 2013	 	All	 	All	 	Initial Release
	 	 	 	 	 	 	 	 	 

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Appendix 3. Key
Contacts

 

	 	 	Navidea	 	NORD
	Quality Assurance and Regulatory	 	[*]

        Phone: [*]

        Wireless:

        Fax: [*]

        [*] 

         

        Backup:

        [*]

        Phone: [*]

        Wireless:

        Fax:[*]

        [*] 
	 	[*]

        Phone: [*]

        Fax: [*]

        [*]

         

         

        Back-up:

        [*]

        Phone:[*]

        Fax:[*]

        [*]

         

	 	 	 	 	 
	CMC Operations,  Shipping,  Logistics, Inventory	 	[*]

        Phone: [*]

        Wireless:

        Fax: [*]

        [*] 

         

        Backup:

        [*]

        Wireless: [*]

        [*]
	 	[*]

        Phone: [*]

        Fax: [*]

        [*]

         

         

        Back-up:

        [*]

        Phone: [*]

        Fax: [*]

        [*] 

 

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Appendix 4. Signature
Page

 

Quality Assurance Agreement

Between

Nordion (Canada) Inc.

447 March Road

Ottawa, Ontario, Canada

and

Navidea Biopharmaceuticals, Inc.

425 Metro Place North, Suite 450

Dublin, Ohio 43017-1367

 

Written by:

Navidea Biopharmaceuticals, Inc.

Rebecca Csak, QA Compliance Specialist

 

Approved by:

 

	 	 	 
	Navidea Biopharmaceuticals, Inc.	 	Date
	David Casebier V.P., CMC	 	 
	 	 	 
	 	 	 
	Navidea Biopharmaceuticals, Inc.	 	Date
	Rodger Brown, V.P., Global Regulatory Operations & Quality Assurance	 	 
	 	 	 
	 	 	 
	Nordion (Canada) Inc.	 	Date
	Jeff Whyte, Director, Quality, Safety and Regulatory Affairs	 	 
	 	 	 
	 	 	 
	Nordion (Canada) Inc.	 	Date
	Ron McGregor, Vice-President, Regulatory and EHS Compliance	 	 

 

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SCHEDULE F

 

Initial Amounts to be Provided and
Specifications for Precursor 

and Reference Standards

 

	Initial Amounts to be Provided
	NAV5001	 	NAV5010	 	NAV5011
	[*]	 	[*]	 	[*]
	[*]	 	[*]	 	[*]
	[*]	 	[*]	 	[*]

 

	NAV5001 Analytical Information to be Supplied
	Test	 	Specifications
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]

 

	NAV5010 Certificate of Analysis
	Tests	 	Specifications
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]

 

	NAV5011 Analytical Information to be Supplied
	Test	 	Specifications
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]
	[*]	 	[*]

 

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 SCHEDULE G

 

CHANGE IN SCOPE FORM

Effective Date: _____, 2013

 

This amendment shall form a change in
scope order (“Change in Scope Order”) to the existing (INSERT SCHEDULE WHICH IS BEING MODIFIED) executed on
_______________, 2013 between Navidea Biopharmaceuticals, Inc. (hereinafter referred to as “Navidea”)
and Nordion (Canada) Inc. (hereinafter referred to as “Nordion”). All Articles and provisions of the (INSERT
SCHEDULE WHICH IS BEING MODIFIED) remain in effect and will apply to all subsequent amendments to that (INSERT SCHEDULE WHICH
IS BEING MODIFIED), unless specifically stated as otherwise herein.

 

The purpose of this Change in Scope Order
is set forth below.

 

Change in Scope Order Description for
[123I]NAV5001

 o

 o

Note to draft; Please insert
columns

	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	Total	 	 

 

Original Project Budget:

Change Order No. 1 Value:
      

Revised Project Total: 

See Attachment __ (Revised
Schedule __) and __ (Revised Project Budget) incorporated herein by reference.

 

The scope changes will be charged to Navidea
as follows:

 

		(i)	Nordion's actual, documented cost
                                                               for any materials, Equipment, third party services obtained via
                                                               a Nordion purchase order, or Nordion inventory obtained via inventory
                                                               requisition;

		(ii)	Nordion labour rate is [*];

 

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		(iii)	Nordion staff travel and accommodation
                                                                 shall be reimbursed to Nordion at cost, provided such amounts
                                                                 are approved by Navidea in advance. Time incurred during travel
                                                                 to destinations shall be billed to Navidea for each person half
                                                                 day or less of travel at the rate of [*].

  

		(iv)	Third party services and materials
                                                                will be estimated by Nordion based on the available information
                                                                at the time the estimate is being prepared. Actual costs or exchange
                                                                rates may vary as against original cost projections as firm quotations
                                                                are obtained from vendors, favorably or unfavorably affecting
                                                                the cost thereof.

 

		(v)	All quoted amounts do not include
                                                               any services, sales, use, value added and any and all other taxes
                                                               for which Navidea is responsible. All such taxes will be paid by
                                                               Navidea.

 

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