Document:

exv4w1

 

     

Exhibit 4.1

	. NNNNN
COMMON STOCK COMMON STOCK
PAR VALUE $0.0001 THIS CERTIFICATE IS TRANSFERRABLE IN
NEW YORK, NY OR DENVER, CO
Certificate Shares Number * * 6 0 0 6 2 0 * * * * * * ZQ 000451 * * * 6 0 0 6 2 0 * * * * *
GENOMIC HEALTH, INC. * * * * 6 0 0 6 2 0 * * * *
INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE * * * * * 6 0 0 6 2 0 * * * 100,000,000
AUTHORIZED SHARES $0.0001 PAR VALUE * * * * * * 6 0 0 6 2 0 * *
** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample
**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample
**** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample
**** Mr. Alexander David THIS CERTIFIES THAT Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander
David Sample MR. SAMPLE & MRS. SAMPLE &**** Mr. Alexander David Sample **** Mr. Alexander David
Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. CUSIP 37244C 10 1
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander MR. SAMPLE & MRS. SAMPLE David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr. Alexander SEE REVERSE FOR CERTAIN DEFINITIONS
David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander
David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Alexander David Sample **** Mr. Alexander David Sample **** Mr. Alexander David Sample **** Mr.
Sample **** Mr. Sample
is the owner of
**600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**
Shares****600620**Shares****600620**Shares***
*600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**S
hares****600620**Shares****600620**Shares****
600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Sh
ares****600620**Shares****600620**Shares****6
00620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Sha
res****600620**Shares****600620**Shares****60 * * * SIX HUNDRED THOUSAND
0620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shar
es****600620**Shares****600620**Shares****600
620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Share
s***600620**Shares****600620**Shares****60062
0**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares*
***600620**Shares****600620**Shares****600620
**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares**
**600620**Shares****600620**Shares****600620*
*Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares***
*600620**Shares****600620**Shares****600620** SIX HUNDRED AND TWENTY* * *
Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****

600620**Shares****600620**Shares****600620**S
hares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****600620**Shares****6
00620**Shares****600620**Shares****600620**Sh
FULLY-PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK OF
Genomic Health, Inc. (hereinafter called the “Company”), transferable on the books of the Company
in person or by duly authorized attorney, upon surrender of this Certificate properly endorsed.
This Certificate and the shares represented hereby, are issued and shall be held subject to all of
the provisions of the Articles of Incorporation, as amended, and the By-Laws, as amended, of the
Company (copies of which are on file with the Company and with the Transfer Agent), to all of which
each holder, by acceptance hereof, assents. This Certificate is not valid unless countersigned and
registered by the Transfer Agent and Registrar.
Witness the facsimile seal of the Company and the facsimile signatures of its duly authorized
officers.
DATED <<Month Day, Year>>
HEAL
FACSIMILE SIGNATURE TO COME MICT COUNTERSIGNED AND REGISTERED:
H,
N O I COMPUTERSHARE TRUST CO., INC.
NC .
President G E (DENVER)
TRANSFER AGENT AND REGISTRAR,
2000
DELAWARE
FACSIMILE SIGNATURE TO COME
By
Secretary AUTHORIZED SIGNATURE 14969
SECURITY INSTRUCTIONS ON REVERSE

 

GENOMIC HEALTH INC.

The following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

	 	 	 	 	 	 	 	 	 	 	 	 	 
	TEN COM

	 	- as tenants in common
	 	UNIF GIFT MIN ACT-
	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 

	Custodian	 	 
	 	 
	 

	 	 	 	 	 	(Cust)
	 	 	 	(Minor)	 	 
	TEN ENT	 	- as tenants by the entireties	 	 	under Uniform Gifts to Minors Act	 	 	 
	 

	 	 	 	 	 	 	 	 	 	 
	 	 
	 

	 	 	 	 	 	 	 	 	 	(State)	 	 
	JT TEN	 	- as joint tenants with right of survivorship and not as tenants in common	 	UNIF TRF MIN ACT	 	 	 	Custodian (until age      )	 	 
	 

	 	 	 	 	 	 

	 	 	 	 	 	 

	 

	 	 	 	 	 	(Cust)
	 	 	 	 	 	(Minor)
	 	 	 	 	 	 	under Uniform Transfers to Minors Act	 	 
	 

	 	 	 	 	 	 	 	 	 	 	 	 

	 

	 	 	 	 	 	 	 	 	 	 	 	(State)
	 

	 	Additional abbreviations may also be used though not in the above list.	 	 	 	 	 

For value received,                      hereby sell, assign and transfer unto

	 	 	 	 	 
	PLEASE INSERT SOCIAL SECURITY

OR OTHER IDENTIFYING NUMBER

OF ASSIGNEE

	 	 	 	 

 

 

(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE)

 

 

 

Shares of the common stock represented by the within Certificate, and do hereby irrevocably constitute and appoint

 

Attorney to transfer the said stock on the books of the within-named Corporation with full power of substitution in the premises.

	 	 	 	 	 	 	 	 	 	 	 
	Dated:

	 	 	 	20	 	 	 	Signature:	 	 
	 

	 	 

	 	 	 	 

	 	 	 	 

	 	 	 
	Signature(s) Guaranteed:
	 
	 	 
	BY:
	 	 
	 
	 	 

	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR
INSTITUTION (Banks, Stockbrokers, Savings and Loan Associations and Credit Unions) WITH
MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM,
PURSUANT TO S.E.C. RULE 17Ad-15.

	 	 	 	 	 
	Signature:
	 	 	 	 
	 
	 	 

	 

	 	Notice:
	 	THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS
WRITTEN UPON THE FACE OF THE CERTIFICATE, IN EVERY PARTICULAR, WITHOUT
ALTERATION OR ENLARGEMENT, OR ANY CHANGE WHATEVER.exv10w3

 

Exhibit 10.3

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

(Adopted by the Board on September 8, 2005)

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

 

 

Table of Contents

	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	 	Page	 
	SECTION 1.	 	ESTABLISHMENT AND PURPOSE.
	 	 	1	 
	SECTION 2.	 	DEFINITIONS.
	 	 	1	 
	 	(a	)	 	“Affiliate”
	 	 	1	 
	 	(b	)	 	“Award”
	 	 	1	 
	 	(c	)	 	“Board of Directors”
	 	 	1	 
	 	(d	)	 	“Change in Control”
	 	 	1	 
	 	(e	)	 	“Code”
	 	 	2	 
	 	(f	)	 	“Committee”
	 	 	2	 
	 	(g	)	 	“Company”
	 	 	2	 
	 	(h	)	 	“Consultant”
	 	 	2	 
	 	(i	)	 	“Employee”
	 	 	3	 
	 	(j	)	 	“Exchange Act”
	 	 	3	 
	 	(k	)	 	“Exercise Price”
	 	 	3	 
	 	(l	)	 	“Fair Market Value”
	 	 	3	 
	 	(m	)	 	“ISO”
	 	 	3	 
	 	(n	)	 	“Nonstatutory Option” or “NSO”
	 	 	3	 
	 	(o	)	 	“Offeree”
	 	 	3	 
	 	(p	)	 	“Option”
	 	 	4	 
	 	(q	)	 	“Optionee”
	 	 	4	 
	 	(r	)	 	“Outside Director”
	 	 	4	 
	 	(s	)	 	“Parent”
	 	 	4	 
	 	(t	)	 	“Participant”
	 	 	4	 
	 	(u	)	 	“Plan”
	 	 	4	 
	 	(v	)	 	“Purchase Price”
	 	 	4	 
	 	(w	)	 	“Restricted Share”
	 	 	4	 
	 	(x	)	 	“Restricted Share Agreement”
	 	 	4	 
	 	(y	)	 	“SAR”
	 	 	4	 
	 	(z	)	 	“SAR Agreement”
	 	 	4	 
	 	(aa	)	 	“Service”
	 	 	4	 
	 	(bb	)	 	“Share”
	 	 	4	 
	 	(cc	)	 	“Stock”
	 	 	5	 
	 	(dd	)	 	“Stock Option Agreement”
	 	 	5	 
	 	(ee	)	 	“Stock Unit”
	 	 	5	 
	 	(ff	)	 	“Stock Unit Agreement”
	 	 	5	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	 	(gg	)	 	“Subsidiary”
	 	 	5	 
	SECTION 3.	 	ADMINISTRATION.
	 	 	5	 
	 	(a	)	 	Committee Composition
	 	 	5	 
	 	(b	)	 	Committee for Non-Officer Grants
	 	 	5	 
	 	(c	)	 	Committee Procedures
	 	 	5	 
	 	(d	)	 	Committee Responsibilities
	 	 	6	 
	SECTION 4.	 	ELIGIBILITY.
	 	 	7	 
	 	(a	)	 	General Rule
	 	 	7	 
	 	(b	)	 	Automatic
Grants to Outside Directors
	 	 	7	 
	 	(c	)	 	Ten-Percent Stockholders
	 	 	8	 
	 	(d	)	 	Attribution Rules
	 	 	8	 
	 	(e	)	 	Outstanding Stock
	 	 	8	 
	SECTION 5.	 	STOCK SUBJECT TO PLAN.
	 	 	8	 
	 	(a	)	 	Basic Limitation
	 	 	8	 
	 	(b	)	 	Award Limitation
	 	 	9	 
	 	(c	)	 	Additional Shares
	 	 	9	 
	SECTION 6.	 	RESTRICTED SHARES.
	 	 	9	 
	 	(a	)	 	Restricted Stock Agreement
	 	 	9	 
	 	(b	)	 	Payment for Awards
	 	 	9	 
	 	(c	)	 	Vesting
	 	 	9	 
	 	(d	)	 	Voting and Dividend Rights
	 	 	9	 
	 	(e	)	 	Restrictions on Transfer of Shares
	 	 	9	 
	SECTION 7.	 	TERMS AND CONDITIONS OF OPTIONS.
	 	 	10	 
	 	(a	)	 	Stock Option Agreement
	 	 	10	 
	 	(b	)	 	Number of Shares
	 	 	10	 
	 	(c	)	 	Exercise Price
	 	 	10	 
	 	(d	)	 	Withholding Taxes
	 	 	10	 
	 	(e	)	 	Exercisability and Term
	 	 	10	 
	 	(f	)	 	Exercise of Options
	 	 	10	 
	 	(g	)	 	Effect of Change in Control
	 	 	11	 
	 	(h	)	 	No Rights as a Stockholder
	 	 	11	 
	 	(i	)	 	Modification, Extension and Renewal of Options
	 	 	11	 
	 	(j	)	 	Restrictions on Transfer of Shares
	 	 	11	 
	 	(k	)	 	Buyout Provisions
	 	 	11	 
	SECTION 8.	 	PAYMENT FOR SHARES.
	 	 	11	 
	 	(a	)	 	General Rule
	 	 	11	 
	 	(b	)	 	Surrender of Stock
	 	 	11	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	 	(c	)	 	Services Rendered
	 	 	12	 
	 	(d	)	 	Cashless Exercise
	 	 	12	 
	 	(e	)	 	Exercise/Pledge
	 	 	12	 
	 	(f	)	 	Promissory Note
	 	 	12	 
	 	(g	)	 	Other Forms of Payment
	 	 	12	 
	 	(h	)	 	Limitations under Applicable Law
	 	 	12	 
	SECTION 9.	 	STOCK APPRECIATION RIGHTS.
	 	 	12	 
	 	(a	)	 	SAR Agreement
	 	 	12	 
	 	(b	)	 	Number of Shares
	 	 	12	 
	 	(c	)	 	Exercise Price
	 	 	12	 
	 	(d	)	 	Exercisability and Term
	 	 	12	 
	 	(e	)	 	Effect of Change in Control
	 	 	13	 
	 	(f	)	 	Exercise of SARs
	 	 	13	 
	 	(g	)	 	Modification or Assumption of SARs
	 	 	13	 
	 	(h	)	 	Buyout Provisions
	 	 	13	 
	SECTION 10.	 	STOCK UNITS.
	 	 	13	 
	 	(a	)	 	Stock Unit Agreement
	 	 	13	 
	 	(b	)	 	Payment for Awards
	 	 	13	 
	 	(c	)	 	Vesting Conditions
	 	 	13	 
	 	(d	)	 	Voting and Dividend Rights
	 	 	14	 
	 	(e	)	 	Form and Time of Settlement of Stock Units
	 	 	14	 
	 	(f	)	 	Death of Recipient
	 	 	14	 
	 	(g	)	 	Creditors’ Rights
	 	 	14	 
	SECTION 11.	 	ADJUSTMENT OF SHARES.
	 	 	14	 
	 	(a	)	 	Adjustments
	 	 	14	 
	 	(b	)	 	Dissolution or Liquidation
	 	 	15	 
	 	(c	)	 	Reorganizations
	 	 	15	 
	 	(d	)	 	Reservation of Rights
	 	 	15	 
	SECTION 12.	 	DEFERRAL OF AWARDS.
	 	 	16	 
	 	(a	)	 	Committee Powers
	 	 	16	 
	 	(b	)	 	General Rules
	 	 	16	 
	SECTION 13.	 	AWARDS UNDER OTHER PLANS.
	 	 	16	 
	SECTION 14.	 	PAYMENT OF DIRECTOR’S FEES IN SECURITIES.
	 	 	17	 
	 	(a	)	 	Effective Date
	 	 	17	 
	 	(b	)	 	Elections to Receive NSOs, Restricted Shares or Stock Units
	 	 	17	 
	 	(c	)	 	Number and Terms of NSOs, Restricted Shares or Stock Units
	 	 	17	 
	SECTION 15.	 	LEGAL AND REGULATORY REQUIREMENTS.
	 	 	17	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	SECTION 16.	 	WITHHOLDING TAXES.
	 	 	17	 
	 	(a	)	 	General
	 	 	17	 
	 	(b	)	 	Share Withholding
	 	 	17	 
	SECTION 17.	 	OTHER PROVISIONS APPLICABLE TO AWARDS.
	 	 	18	 
	 	(a	)	 	Transferability
	 	 	18	 
	 	(b	)	 	Qualifying Performance Criteria
	 	 	18	 
	SECTION 18.	 	NO EMPLOYMENT RIGHTS.
	 	 	18	 
	SECTION 19.	 	DURATION AND AMENDMENTS.
	 	 	19	 
	 	(a	)	 	Term of the Plan
	 	 	19	 
	 	(b	)	 	Right to Amend or Terminate the Plan
	 	 	19	 
	 	(c	)	 	Effect of Termination
	 	 	19	 
	SECTION 20.	 	EXECUTION.
	 	 	20	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

-iv-

 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

SECTION 1. ESTABLISHMENT AND PURPOSE.

     The Plan was adopted by the Board of Directors on September 8, 2005, and shall be effective as
of the date of the initial offering of Stock to the public pursuant to a registration statement
filed by the Company with the Securities and Exchange Commission (the “Effective Date”). The
purpose of the Plan is to promote the long-term success of the Company and the creation of
stockholder value by (a) encouraging Employees, Outside Directors and Consultants to focus on
critical long-range objectives, (b) encouraging the attraction and retention of Employees, Outside
Directors and Consultants with exceptional qualifications and (c) linking Employees, Outside
Directors and Consultants directly to stockholder interests through increased stock ownership. The
Plan seeks to achieve this purpose by providing for Awards in the form of restricted shares, stock
units, options (which may constitute incentive stock options or nonstatutory stock options) or
stock appreciation rights.

SECTION 2. DEFINITIONS.

     (a) “Affiliate” shall mean any entity other than a Subsidiary, if the Company and/or one of
more Subsidiaries own not less than 50% of such entity.

     (b) “Award” shall mean any award of an Option, a SAR, a Restricted Share or a Stock Unit under
the Plan.

     (c) “Board of Directors” shall mean the Board of Directors of the Company, as constituted from
time to time.

     (d) “Change in Control” shall mean the occurrence of any of the following events:

     (i) A change in the composition of the Board of Directors occurs, as a result of which
fewer than one-half of the incumbent directors are directors who either:

     (A) Had been directors of the Company on the “look-back date” (as defined
below) (the “original directors”); or

     (B) Were elected, or nominated for election, to the Board of Directors with the
affirmative votes of at least a majority of the aggregate of the original directors
who were still in office at the time of the election or nomination and the
directors whose election or nomination was previously so approved (the
“continuing directors”); or

     (ii) Any “person” (as defined below) who by the acquisition or aggregation of
securities, is or becomes the “beneficial owner” (as defined in Rule 13d-3 under the
Exchange Act), directly or indirectly, of securities of the Company representing 50% or more
of the combined voting power of the Company’s then outstanding securities

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

-1-

 

ordinarily (and apart from rights accruing under special circumstances) having the right to vote at
elections of directors (the “Base Capital Stock”); except that any change in the relative
beneficial ownership of the Company’s securities by any person resulting solely from a
reduction in the aggregate number of outstanding shares of Base Capital Stock, and any
decrease thereafter in such person’s ownership of securities, shall be disregarded until
such person increases in any manner, directly or indirectly, such person’s beneficial
ownership of any securities of the Company; or

     (iii) The consummation of a merger or consolidation of the Company with or into another
entity or any other corporate reorganization, if persons who were not stockholders of the
Company immediately prior to such merger, consolidation or other reorganization own
immediately after such merger, consolidation or other reorganization 50% or more of the
voting power of the outstanding securities of each of (A) the continuing or surviving entity
and (B) any direct or indirect parent corporation of such continuing or surviving entity; or

     (iv) The sale, transfer or other disposition of all or substantially all of the
Company’s assets.

     For purposes of subsection (d)(i) above, the term “look-back” date shall mean the later of (1)
the Effective Date or (2) the date 24 months prior to the date of the event that may constitute a
Change in Control.

     For purposes of subsection (d)(ii)) above, the term “person” shall have the same meaning as
when used in Sections 13(d) and 14(d) of the Exchange Act but shall exclude (1) a trustee or other
fiduciary holding securities under an employee benefit plan maintained by the Company or a Parent
or Subsidiary and (2) a corporation owned directly or indirectly by the stockholders of the Company
in substantially the same proportions as their ownership of the Stock.

     Any other provision of this Section 2(d) notwithstanding, a transaction shall not constitute a
Change in Control if its sole purpose is to change the state of the Company’s incorporation or to
create a holding company that will be owned in substantially the same proportions by the persons
who held the Company’s securities immediately before such transaction, and a Change in Control
shall not be deemed to occur if the Company files a registration statement with the United States
Securities and Exchange Commission for the initial offering of Stock to the public.

     (e) “Code” shall mean the Internal Revenue Code of 1986, as amended.

     (f) “Committee” shall mean the Compensation Committee as designated by the Board of Directors,
which is authorized to administer the Plan, as described in Section 3 hereof.

     (g) “Company” shall mean Genomic Health, Inc., a Delaware corporation.

     (h) “Consultant” shall mean a consultant or advisor who provides bona fide services to the
Company, a Parent, a Subsidiary or an Affiliate as an independent contractor (not

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

-2-

 

including service
as a member of the Board of Directors) or a member of the board of directors of a Parent or a
Subsidiary, in each case who is not an Employee.

     (i) “Employee” shall mean any individual who is a common-law employee of the Company, a
Parent, a Subsidiary or an Affiliate.

     (j) “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended.

     (k) “Exercise Price” shall mean, in the case of an Option, the amount for which one Share may
be purchased upon exercise of such Option, as specified in the applicable Stock Option Agreement.
“Exercise Price,” in the case of a SAR, shall mean an amount, as specified in the applicable SAR
Agreement, which is subtracted from the Fair Market Value of one Share in determining the amount
payable upon exercise of such SAR.

     (l) “Fair Market Value” with respect to a Share, shall mean the market price of one Share,
determined by the Committee as follows:

     (i) If the Stock was traded over-the-counter on the date in question but was not traded
on The Nasdaq Stock Market, then the Fair Market Value shall be equal to the last
transaction price quoted for such date by the OTC Bulletin Board or, if not so quoted, shall
be equal to the mean between the last reported representative bid and asked prices quoted
for such date by the principal automated inter-dealer quotation system on which the Stock is
quoted or, if the Stock is not quoted on any such system, by the Pink Sheets LLC;

     (ii) If the Stock was traded on The Nasdaq Stock Market, then the Fair Market Value
shall be equal to the last reported sale price quoted for such date by The Nasdaq Stock
Market;

     (iii) If the Stock was traded on a United States stock exchange on the date in
question, then the Fair Market Value shall be equal to the closing price reported for such
date by the applicable composite-transactions report; and

     (iv) If none of the foregoing provisions is applicable, then the Fair Market Value
shall be determined by the Committee in good faith on such basis as it deems appropriate.

In all cases, the determination of Fair Market Value by the Committee shall be conclusive and
binding on all persons.

     (m) “ISO” shall mean an employee incentive stock option described in Section 422 of the Code.

     (n) “Nonstatutory Option” or “NSO” shall mean an employee stock option that is not an ISO.

     (o) “Offeree” shall mean an individual to whom the Committee has offered the right to acquire
Shares under the Plan (other than upon exercise of an Option).

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

-3-

 

     (p) “Option” shall mean an ISO or Nonstatutory Option granted under the Plan and entitling the
holder to purchase Shares.

     (q) “Optionee” shall mean an individual or estate who holds an Option or SAR.

     (r) “Outside Director” shall mean a member of the Board of Directors who is not a common-law
employee of, or paid consultant to, the Company, a Parent or a Subsidiary.

     (s) “Parent” shall mean any corporation (other than the Company) in an unbroken chain of
corporations ending with the Company, if each of the corporations other than the Company owns stock
possessing 50% or more of the total combined voting power of all classes of stock in one
of the other corporations in such chain. A corporation that attains the status of a Parent on
a date after the adoption of the Plan shall be a Parent commencing as of such date.

     (t) “Participant” shall mean an individual or estate who holds an Award.

     (u) “Plan” shall mean this 2005 Stock Incentive Plan of Genomic Health, Inc., as amended from
time to time.

     (v) “Purchase Price” shall mean the consideration for which one Share may be acquired under
the Plan (other than upon exercise of an Option), as specified by the Committee.

     (w) “Restricted Share” shall mean a Share awarded under the Plan.

     (x) “Restricted Share Agreement” shall mean the agreement between the Company and the
recipient of a Restricted Share which contains the terms, conditions and restrictions pertaining to
such Restricted Shares.

     (y) “SAR” shall mean a stock appreciation right granted under the Plan.

     (z) “SAR Agreement” shall mean the agreement between the Company and an Optionee which
contains the terms, conditions and restrictions pertaining to his or her SAR.

     (aa) “Service” shall mean service as an Employee, Consultant or Outside Director, subject to
such further limitations as may be set forth in the Plan or the applicable Stock Option Agreement,
SAR Agreement, Restricted Share Agreement or Stock Unit Agreement. Service does not terminate when
an Employee goes on a bona fide leave of absence, that was approved by the Company in writing, if
the terms of the leave provide for continued Service crediting, or when continued Service crediting
is required by applicable law. However, for purposes of determining whether an Option is entitled
to ISO status, an Employee’s employment will be treated as terminating 90 days after such Employee
went on leave, unless such Employee’s right to return to active work is guaranteed by law or by a
contract. Service terminates in any event when the approved leave ends, unless such Employee
immediately returns to active work. The Company
determines which leaves count toward Service, and when Service terminates for all purposes
under the Plan.

     (bb) “Share” shall mean one share of Stock, as adjusted in accordance with Section 8 (if
applicable). All share numbers herein assume, and no adjustment shall be made in respect of,

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the one-for-three reverse split of the Stock approved by the Board of Directors on the date of initial
adoption of the Plan.

     (cc) “Stock” shall mean the Common Stock of the Company.

     (dd) “Stock Option Agreement” shall mean the agreement between the Company and an Optionee
that contains the terms, conditions and restrictions pertaining to his Option.

     (ee) “Stock Unit” shall mean a bookkeeping entry representing the equivalent of one Share, as
awarded under the Plan.

     (ff) “Stock Unit Agreement” shall mean the agreement between the Company and the recipient of
a Stock Unit which contains the terms, conditions and restrictions pertaining to such Stock Unit.

     (gg) “Subsidiary” shall mean any corporation, if the Company and/or one or more other
Subsidiaries own not less than 50% of the total combined voting power of all classes of outstanding
stock of such corporation. A corporation that attains the status of a Subsidiary on a date after
the adoption of the Plan shall be considered a Subsidiary commencing as of such date.

     (hh) “Total and Permanent Disability” shall mean permanent and total disability as defined by
section 22(e)(3) of the Code.

SECTION 3. ADMINISTRATION.

     (a) Committee Composition. The Plan shall be administered by the Committee. The Committee
shall consist of two or more directors of the Company, who shall be appointed by the Board. In
addition, the composition of the Committee shall satisfy (i) such requirements as the Securities
and Exchange Commission may establish for administrators acting under plans intended to qualify for
exemption under Rule 16b-3 (or its successor) under the Exchange Act; and (ii) such
requirements as the Internal Revenue Service may establish for outside directors acting under
plans intended to qualify for exemption under Section 162(m)(4)(C) of the Code.

     (b) Committee for Non-Officer Grants. The Board may also appoint one or more separate
committees of the Board, each composed of one or more directors of the Company who need not satisfy
the requirements of Section 3(a), who may administer the Plan with respect to Employees who are not
considered officers or directors of the Company under Section 16 of the Exchange Act, may grant
Awards under the Plan to such Employees and may determine all terms of such grants. Within the
limitations of the preceding sentence, any reference in the Plan to the Committee shall include
such committee or committees appointed pursuant to the preceding sentence. The Board of Directors
may also authorize one or more officers of the Company to designate Employees, other than officers
under Section 16 of the Exchange Act, to receive Awards and/or to determine the number of such
Awards to be received by such persons; provided, however, that the Board of Directors shall specify
the total number of Awards that such officers may so award.

     (c) Committee Procedures. The Board of Directors shall designate one of the members of the
Committee as chairman. The Committee may hold meetings at such times and

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places as it shall
determine. The acts of a majority of the Committee members present at meetings at which a quorum
exists, or acts reduced to or approved in writing by all Committee members, shall be valid acts of
the Committee.

     (d) Committee Responsibilities. Subject to the provisions of the Plan, the Committee shall
have full authority and discretion to take the following actions:

     (i) To interpret the Plan and to apply its provisions;

     (ii) To adopt, amend or rescind rules, procedures and forms relating to the Plan;

     (iii) To adopt, amend or terminate sub-plans established for the purpose of satisfying
applicable foreign laws including qualifying for preferred tax treatment under applicable
foreign tax laws;

     (iv) To authorize any person to execute, on behalf of the Company, any instrument
required to carry out the purposes of the Plan;

     (v) To determine when Awards are to be granted under the Plan;

     (vi) To select the Offerees and Optionees;

     (vii) To determine the number of Shares to be made subject to each Award;

     (viii) To prescribe the terms and conditions of each Award, including (without
limitation) the Exercise Price and Purchase Price, and the vesting or duration of the Award
(including accelerating the vesting of Awards, either at the time of the Award or
thereafter, without the consent of the Participant), to determine whether an Option is to be
classified as an ISO or as a Nonstatutory Option, and to specify the provisions of the
agreement relating to such Award;

     (ix) To amend any outstanding Award agreement, subject to applicable legal restrictions
and to the consent of the Participant if the Participant’s rights or obligations would be
materially impaired;

     (x) To prescribe the consideration for the grant of each Award or other right under the
Plan and to determine the sufficiency of such consideration;

     (xi) To determine the disposition of each Award or other right under the Plan in the
event of a Participant’s divorce or dissolution of marriage;

     (xii) To determine whether Awards under the Plan will be granted in replacement of
other grants under an incentive or other compensation plan of an acquired business;

     (xiii) To correct any defect, supply any omission, or reconcile any inconsistency in
the Plan or any Award agreement;

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     (xiv) To establish or verify the extent of satisfaction of any performance goals or
other conditions applicable to the grant, issuance, exercisability, vesting and/or ability
to retain any Award; and

     (xv) To take any other actions deemed necessary or advisable for the administration of
the Plan.

Subject to the requirements of applicable law, the Committee may designate persons other than
members of the Committee to carry out its responsibilities and may prescribe such conditions and
limitations as it may deem appropriate, except that the Committee may not delegate its authority
with regard to the selection for participation of or the granting of Options or other rights under
the Plan to persons subject to Section 16 of the Exchange Act. All decisions, interpretations and
other actions of the Committee shall be final and binding on all Offerees, all Optionees, and all
persons deriving their rights from an Offeree or Optionee. No member of the Committee shall be
liable for any action that he has taken or has failed to take in good faith with respect to the
Plan, any Option, or any right to acquire Shares under the Plan.

SECTION 4. ELIGIBILITY.

     (a) General Rule. Only common-law employees of the Company, a Parent or a Subsidiary shall be
eligible for the grant of ISOs. Only Employees, Consultants and Outside Directors shall be eligible
for the grant of Restricted Shares, Stock Units, Nonstatutory Options or SARs.

     (b) Automatic Grants to Outside Directors.

     (i) Each Outside Director who first joins the Board of Directors on or after the
Effective Date, and who was not previously an Employee, shall receive a Nonstatutory Option,
subject to approval of the Plan by the Company’s stockholders, to purchase 16,500 Shares
(subject to adjustment under Section 11) on the date of his or her election to the Board of
Directors. Twenty-five percent (25%) of the Shares subject to each Option granted under this
Section 4(b)(i) shall vest and become exercisable on the first anniversary of the date of
grant. The balance of the Shares subject to such Option (i.e. the remaining seventy-five
percent (75%)) shall vest and become exercisable monthly over a three-year period beginning
on the day which is one month after the first anniversary of the date of grant, at a monthly
rate of 2.0833% of the total number of Shares subject to such Option. Notwithstanding the
foregoing, each such Option shall become vested if a Change in Control occurs with respect
to the Company during the Optionee’s Service.

     (ii) On the first business day following the conclusion of each regular annual meeting
of the Company’s stockholders, commencing with the annual meeting occurring after the
Effective Date, each Outside Director who was not elected to the Board for the first time at
such meeting and who will continue serving as a member of the Board of Directors thereafter
shall receive an Option to purchase 8,250 Shares (subject to adjustment under Section 11),
provided that such Outside Director has served on the Board of Directors for at least six
months. Each Option granted under this Section 4(b)(ii)

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shall vest and become exercisable on
the first anniversary of the date of grant; provided, however, that each such Option shall
become exercisable in full immediately prior to the next regular annual meeting of the
Company’s stockholders following such date of grant in the event such meeting occurs prior
to such first anniversary date. Notwithstanding the foregoing, each Option granted under
this Section 4(b)(ii) shall become vested if a Change in Control occurs with respect to the
Company during the Optionee’s Service.

     (iii) The Exercise Price of all Nonstatutory Options granted to an Outside Director
under this Section 4(b) shall be equal to 100% of the Fair Market Value of a Share on the
date of grant, payable in one of the forms described in Section 8(a), (b) or (d).

     (iv) All Nonstatutory Options granted to an Outside Director under this Section 4(b)
shall terminate on the earlier of (A) the day before the tenth anniversary of the date of
grant of such Options or (B) the date twelve months after the termination of such Outside
Director’s Service for any reason; provided, however, that any such Options that are not
vested upon the termination of the Outside Director’s service as a member of the Board of
Directors for any reason shall terminate immediately and may not be exercised.

     (c) Ten-Percent Stockholders. An Employee who owns more than 10% of the total combined voting power of all classes of
outstanding stock of the Company, a Parent or Subsidiary shall not be eligible for the grant of an
ISO unless such grant satisfies the requirements of Section 422(c)(5) of the Code.

     (d) Attribution Rules. For purposes of Section 4(c) above, in determining stock ownership, an
Employee shall be deemed to own the stock owned, directly or indirectly, by or for such Employee’s
brothers, sisters, spouse, ancestors and lineal descendants. Stock owned, directly or indirectly,
by or for a corporation, partnership, estate or trust shall be deemed to be owned proportionately
by or for its stockholders, partners or beneficiaries.

     (e) Outstanding Stock. For purposes of Section 4(c) above, “outstanding stock” shall include
all stock actually issued and outstanding immediately after the grant. “Outstanding stock” shall
not include shares authorized for issuance under outstanding options held by the Employee or by any
other person.

SECTION 5. STOCK SUBJECT TO PLAN.

     (a) Basic Limitation. Shares offered under the Plan shall be authorized but unissued Shares or
treasury Shares. The aggregate number of Shares authorized for issuance as Awards under the Plan
shall not exceed 5,000,000 Shares. The limitations of this Section 5(a) shall be subject to
adjustment pursuant to Section 11. The number of Shares that are subject to Options or other Awards
outstanding at any time under the Plan shall not exceed the number of Shares which then remain
available for issuance under the Plan. The Company, during the term of the Plan, shall at all times
reserve and keep available sufficient Shares to satisfy the requirements of the Plan.

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     (b) Award Limitation. Subject to the provisions of Section 11, no Participant may receive
Options, SARs, Restricted Shares or Stock Units under the Plan in any calendar year that relate to
more than 1,650,000 Shares.

     (c) Additional Shares. If Restricted Shares or Shares issued upon the exercise of Options are
forfeited, then such Shares shall again become available for Awards under the Plan. If Stock Units,
Options or SARs are forfeited or terminate for any other reason before being exercised, then the
corresponding Shares shall again become available for Awards under the Plan. If Stock Units are
settled, then only the number of Shares (if any) actually issued in settlement of such Stock Units
shall reduce the number available under Section 5(a) and the balance shall again become available
for Awards under the Plan. If SARs are exercised, then only the number of Shares (if any) actually
issued in settlement of such SARs shall reduce the number available in Section 5(a) and the balance
shall again become available for Awards under the Plan.

SECTION 6. RESTRICTED SHARES.

     (a) Restricted Stock Agreement. Each grant of Restricted Shares under the Plan shall be
evidenced by a Restricted Stock Agreement between the recipient and the Company. Such Restricted
Shares shall be subject to all applicable terms of the Plan and may be subject to any other terms
that are not inconsistent with the Plan. The provisions of the various Restricted Stock Agreements
entered into under the Plan need not be identical.

     (b) Payment for Awards. Subject to the following sentence, Restricted Shares may be sold or
awarded under the Plan for such consideration as the Committee may determine, including (without
limitation) cash, cash equivalents, full-recourse promissory notes, past services and future
services.

     (c) Vesting. Each Award of Restricted Shares may or may not be subject to vesting. Vesting
shall occur, in full or in installments, upon satisfaction of the conditions specified in the
Restricted Stock Agreement. A Restricted Stock Agreement may provide for accelerated vesting in the
event of the Participant’s death, disability or retirement or other events. The Committee may
determine, at the time of granting Restricted Shares of thereafter, that all or part of such
Restricted Shares shall become vested in the event that a Change in Control occurs with respect to
the Company.

     (d) Voting and Dividend Rights. The holders of Restricted Shares awarded under the Plan shall
have the same voting, dividend and other rights as the Company’s other stockholders. A Restricted
Stock Agreement, however, may require that the holders of Restricted Shares invest any cash
dividends received in additional Restricted Shares. Such additional Restricted Shares shall be
subject to the same conditions and restrictions as the Award with respect to which the dividends
were paid.

     (e) Restrictions on Transfer of Shares. Restricted Shares shall be subject to such rights of
repurchase, rights of first refusal or other restrictions as the Committee may determine. Such
restrictions shall be set forth in the applicable Restricted Stock Agreement and shall apply in
addition to any general restrictions that may apply to all holders of Shares.

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SECTION 7. TERMS AND CONDITIONS OF OPTIONS.

     (a) Stock Option Agreement. Each grant of an Option under the Plan shall be evidenced by a
Stock Option Agreement between the Optionee and the Company. Such Option shall be subject to all
applicable terms and conditions of the Plan and may be subject to any other terms and conditions
which are not
inconsistent with the Plan and which the Committee deems appropriate for inclusion in a Stock
Option Agreement. The Stock Option Agreement shall specify whether the Option is an ISO or an NSO.
The provisions of the various Stock Option Agreements entered into under the Plan need not be
identical. Options may be granted in consideration of a reduction in the Optionee’s other
compensation.

     (b) Number of Shares. Each Stock Option Agreement shall specify the number of Shares that are
subject to the Option and shall provide for the adjustment of such number in accordance with
Section 11.

     (c) Exercise Price. Each Stock Option Agreement shall specify the Exercise Price. The Exercise
Price of an ISO shall not be less than 100% of the Fair Market Value of a Share on the date of
grant, except as otherwise provided in 4(c), and the Exercise Price of an NSO shall not be less 85%
of the Fair Market Value of a Share on the date of grant. Subject to the foregoing in this Section
7(c), the Exercise Price under any Option shall be determined by the Committee at its sole
discretion. The Exercise Price shall be payable in one of the forms described in Section 8.

     (d) Withholding Taxes. As a condition to the exercise of an Option, the Optionee shall make
such arrangements as the Committee may require for the satisfaction of any federal, state, local or
foreign withholding tax obligations that may arise in connection with such exercise. The Optionee
shall also make such arrangements as the Committee may require for the satisfaction of any federal,
state, local or foreign withholding tax obligations that may arise in connection with the
disposition of Shares acquired by exercising an Option.

     (e) Exercisability and Term. Each Stock Option Agreement shall specify the date when all or
any installment of the Option is to become exercisable. The Stock Option Agreement shall also
specify the term of the Option; provided that the term of an ISO shall in no event exceed 10 years
from the date of grant (five years for Employees described in Section 4(c)). A Stock Option
Agreement may provide for accelerated exercisability in the event of the Optionee’s death,
disability, or retirement or other events and may provide for expiration prior to the end of its
term in the event of the termination of the Optionee’s Service. Options may be awarded in
combination with SARs, and such an Award may provide that the Options will not be exercisable
unless the related SARs are forfeited. Subject to the foregoing in this Section 7(e), the Committee
at its sole discretion shall determine when all or any installment of an Option is to become
exercisable and when an Option is to expire.

     (f) Exercise of Options. Each Stock Option Agreement shall set forth the extent to which the
Optionee shall have the right to exercise the Option following termination of the Optionee’s
Service with the Company and its Subsidiaries, and the right to exercise the Option of any
executors or
administrators of the Optionee’s estate or any person who has acquired such Option(s) directly
from the Optionee by bequest or inheritance. Such provisions shall be

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determined in the sole
discretion of the Committee, need not be uniform among all Options issued pursuant to the Plan, and
may reflect distinctions based on the reasons for termination of Service.

     (g) Effect of Change in Control. The Committee may determine, at the time of granting an
Option or thereafter, that such Option shall become exercisable as to all or part of the Shares
subject to such Option in the event that a Change in Control occurs with respect to the Company.

     (h) No Rights as a Stockholder. An Optionee, or a transferee of an Optionee, shall have no
rights as a stockholder with respect to any Shares covered by his Option until the date of the
issuance of a stock certificate for such Shares. No adjustments shall be made, except as provided
in Section 11.

     (i) Modification, Extension and Renewal of Options. Within the limitations of the Plan, the
Committee may modify, extend or renew outstanding options or may accept the cancellation of
outstanding options (to the extent not previously exercised), whether or not granted hereunder, in
return for the grant of new Options for the same or a different number of Shares and at the same or
a different exercise price, or in return for the grant of the same or a different number of Shares.
The foregoing notwithstanding, no modification of an Option shall, without the consent of the
Optionee, materially impair his or her rights or obligations under such Option.

     (j) Restrictions on Transfer of Shares. Any Shares issued upon exercise of an Option shall be
subject to such special forfeiture conditions, rights of repurchase, rights of first refusal and
other transfer restrictions as the Committee may determine. Such restrictions shall be set forth in
the applicable Stock Option Agreement and shall apply in addition to any general restrictions that
may apply to all holders of Shares.

     (k) Buyout Provisions. The Committee may at any time (a) offer to buy out for a payment in
cash or cash equivalents an Option previously granted or (b) authorize an Optionee to elect to cash
out an Option previously granted, in either case at such time and based upon such terms and
conditions as the Committee shall establish.

SECTION 8. PAYMENT FOR SHARES.

     (a) General Rule. The entire Exercise Price or Purchase Price of Shares issued under the Plan shall be payable
in lawful money of the United States of America at the time when such Shares are purchased, except
as provided in Section 8(b) through Section 8(g) below.

     (b) Surrender of Stock. To the extent that a Stock Option Agreement so provides, payment may
be made all or in part by surrendering, or attesting to the ownership of, Shares which have already
been owned by the Optionee or his representative. Such Shares shall be valued at their Fair Market
Value on the date when the new Shares are purchased under the Plan. The Optionee shall not
surrender, or attest to the ownership of, Shares in payment of the Exercise Price if such action
would cause the Company to recognize compensation expense (or additional compensation expense) with
respect to the Option for financial reporting purposes.

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     (c) Services Rendered. At the discretion of the Committee, Shares may be awarded under the
Plan in consideration of services rendered to the Company or a Subsidiary prior to the award. If
Shares are awarded without the payment of a Purchase Price in cash, the Committee shall make a
determination (at the time of the award) of the value of the services rendered by the Offeree and
the sufficiency of the consideration to meet the requirements of Section 6(b).

     (d) Cashless Exercise. To the extent that a Stock Option Agreement so provides, payment may be
made all or in part by delivery (on a form prescribed by the Committee) of an irrevocable direction
to a securities broker to sell Shares and to deliver all or part of the sale proceeds to the
Company in payment of the aggregate Exercise Price.

     (e) Exercise/Pledge. To the extent that a Stock Option Agreement so provides, payment may be
made all or in part by delivery (on a form prescribed by the Committee) of an irrevocable direction
to a securities broker or lender to pledge Shares, as security for a loan, and to deliver all or
part of the loan proceeds to the Company in payment of the aggregate Exercise Price.

     (f) Promissory Note. To the extent that a Stock Option Agreement or Restricted Stock Agreement
so provides, payment may be made all or in part by delivering (on a form prescribed by the Company)
a full-recourse promissory note.

     (g) Other Forms of Payment. To the extent that a Stock Option Agreement or Restricted Stock
Agreement so provides, payment may be made in any other form that is consistent with applicable
laws, regulations and rules.

     (h) Limitations under Applicable Law. Notwithstanding anything herein or in a Stock Option
Agreement or Restricted Stock Agreement to the contrary, payment may not be made in any form that
is unlawful, as determined by the Committee in its sole discretion.

SECTION 9. STOCK APPRECIATION RIGHTS.

     (a) SAR Agreement. Each grant of a SAR under the Plan shall be evidenced by a SAR Agreement
between the Optionee and the Company. Such SAR shall be subject to all applicable terms of the Plan
and may be subject to any other terms that are not inconsistent with the Plan. The provisions of
the various SAR Agreements entered into under the Plan need not be identical. SARs may be granted
in consideration of a reduction in the Optionee’s other compensation.

     (b) Number of Shares. Each SAR Agreement shall specify the number of Shares to which the SAR
pertains and shall provide for the adjustment of such number in accordance with Section 11.

     (c) Exercise Price. Each SAR Agreement shall specify the Exercise Price. A SAR Agreement may
specify an Exercise Price that varies in accordance with a predetermined formula while the SAR is
outstanding.

     (d) Exercisability and Term. Each SAR Agreement shall specify the date when all or any
installment of the SAR is to become exercisable. The SAR Agreement shall also specify the term of
the SAR. A SAR Agreement may provide for accelerated exercisability in the event of

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the Optionee’s
death, disability or retirement or other events and may provide for expiration prior to the end of
its term in the event of the termination of the Optionee’s service. SARs may be awarded in
combination with Options, and such an Award may provide that the SARs will not be exercisable
unless the related Options are forfeited. A SAR may be included in an ISO only at the time of grant
but may be included in an NSO at the time of grant or thereafter. A SAR granted under the Plan may
provide that it will be exercisable only in the event of a Change in Control.

     (e) Effect of Change in Control. The Committee may determine, at the time of granting a SAR or
thereafter, that such SAR shall become fully exercisable as to all Common Shares subject to such
SAR in the event that a Change in Control occurs with respect to the Company.

     (f) Exercise of SARs. Upon exercise of a SAR, the Optionee (or any person having the right to exercise the SAR
after his or her death) shall receive from the Company (a) Shares, (b) cash or (c) a combination of
Shares and cash, as the Committee shall determine. The amount of cash and/or the Fair Market Value
of Shares received upon exercise of SARs shall, in the aggregate, be equal to the amount by which
the Fair Market Value (on the date of surrender) of the Shares subject to the SARs exceeds the
Exercise Price.

     (g) Modification or Assumption of SARs. Within the limitations of the Plan, the Committee may
modify, extend or assume outstanding SARs or may accept the cancellation of outstanding SARs
(whether granted by the Company or by another issuer) in return for the grant of new SARs for the
same or a different number of shares and at the same or a different exercise price. The foregoing
notwithstanding, no modification of a SAR shall, without the consent of the holder, materially
impair his or her rights or obligations under such SAR.

     (h) Buyout Provisions. The Committee may at any time (a) offer to buy out for a
payment in cash or cash equivalents a SAR previously granted, or (b) authorize an Optionee to elect
to cash out a SAR previously granted, in either case at such time and based upon such terms and
conditions as the Committee shall establish.

SECTION 10. STOCK UNITS.

     (a) Stock Unit Agreement. Each grant of Stock Units under the Plan shall be evidenced by a
Stock Unit Agreement between the recipient and the Company. Such Stock Units shall be subject to
all applicable terms of the Plan and may be subject to any other terms that are not inconsistent
with the Plan. The provisions of the various Stock Unit Agreements entered into under the Plan need
not be identical. Stock Units may be granted in consideration of a reduction in the recipient’s
other compensation.

     (b) Payment for Awards. To the extent that an Award is granted in the form of Stock Units, no
cash consideration shall be required of the Award recipients.

     (c) Vesting Conditions. Each Award of Stock Units may or may not be subject to vesting.
Vesting shall occur, in full or in installments, upon satisfaction of the conditions specified in
the Stock Unit Agreement. A Stock Unit Agreement may provide for accelerated

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vesting in the event
of the Participant’s death, disability or retirement or other events. The Committee may determine,
at the time of granting Stock Units or thereafter, that all or part of such Stock Units shall
become vested in the event that a Change in Control occurs with respect to the Company.

     (d) Voting and Dividend Rights. The holders of Stock Units shall have no voting rights. Prior
to settlement or forfeiture, any Stock Unit awarded under the Plan may, at the Committee’s
discretion, carry with it a right to dividend equivalents. Such right entitles the holder to be
credited with an amount equal to all cash dividends paid on one Share while the Stock Unit is
outstanding. Dividend equivalents may be converted into additional Stock Units. Settlement of
dividend equivalents may be made in the form of cash, in the form of Shares, or in a combination of
both. Prior to distribution, any dividend equivalents which are not paid shall be subject to the
same conditions and restrictions (including without limitation, any forfeiture conditions) as the
Stock Units to which they attach.

     (e) Form and Time of Settlement of Stock Units. Settlement of vested Stock Units may be made
in the form of (a) cash, (b) Shares or (c) any combination of both, as determined by the Committee.
The actual number of Stock Units eligible for settlement may be larger or smaller than the number
included in the original Award, based on predetermined performance factors. Methods of converting
Stock Units into cash may include (without limitation) a method based on the average Fair Market
Value of Shares over a series of trading days. Vested Stock Units may be settled in a lump sum or
in installments. The distribution may occur or commence when all vesting conditions applicable to
the Stock Units have been satisfied or have lapsed, or it may be deferred to any later date. The
amount of a deferred distribution may be increased by an interest factor or by dividend
equivalents. Until an Award of Stock Units is settled, the number of such Stock Units shall be
subject to adjustment pursuant to Section 11.

     (f) Death of Recipient. Any Stock Units Award that becomes payable after the recipient’s death
shall be distributed to the recipient’s beneficiary or beneficiaries. Each recipient of a Stock
Units Award under the Plan shall designate one or more beneficiaries for this purpose by filing the
prescribed form with the Company. A beneficiary designation may be changed by filing the prescribed
form with the Company at any time before the Award recipient’s death. If no beneficiary was
designated or if no designated beneficiary survives the Award recipient, then any Stock Units Award
that becomes payable after the recipient’s death shall be distributed to the recipient’s estate.

     (g) Creditors’ Rights. A holder of Stock Units shall have no rights other than those of a
general creditor of the Company. Stock Units represent an unfunded and unsecured obligation of the
Company, subject to the terms and conditions of the applicable Stock Unit Agreement.

SECTION 11. ADJUSTMENT OF SHARES.

     (a) Adjustments. In the event of a subdivision of the outstanding Stock, a declaration of a
dividend payable in Shares, a declaration of a dividend payable in a form other than Shares in an
amount
that has a material effect on the price of Shares, a combination or consolidation of the
outstanding Stock (by reclassification or otherwise) into a lesser number of Shares, a

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recapitalization, a spin-off or a similar occurrence, the Committee shall make such adjustments as
it, in its sole discretion, deems appropriate in one or more of:

     (i) The number of Options, SARs, Restricted Shares and Stock Units available for future
Awards under Section 5;

     (ii) The limitations set forth in Section 5(b);

     (iii) The number of NSOs to be granted to Outside Directors under Section 4(b);

     (iv) The number of Shares covered by each outstanding Option and SAR;

     (v) The Exercise Price under each outstanding Option and SAR; or

     (vi) The number of Stock Units included in any prior Award which has not yet been
settled.

Except as provided in this Section 11, a Participant shall have no rights by reason of any issue by
the Company of stock of any class or securities convertible into stock of any class, any
subdivision or consolidation of shares of stock of any class, the payment of any stock dividend or
any other increase or decrease in the number of shares of stock of any class.

     (b) Dissolution or Liquidation. To the extent not previously exercised or settled, Options,
SARs and Stock Units shall terminate immediately prior to the dissolution or liquidation of the
Company.

     (c) Reorganizations. In the event that the Company is a party to a merger or other
reorganization, outstanding Awards shall be subject to the agreement of merger or reorganization.
Such agreement shall provide for:

     (i) The continuation of the outstanding Awards by the Company, if the Company is a
surviving corporation;

     (ii) The assumption of the outstanding Awards by the surviving corporation or its
parent or subsidiary;

     (iii) The substitution by the surviving corporation or its parent or subsidiary of its
own awards for the outstanding Awards;

     (iv) Full exercisability or vesting and accelerated expiration of the outstanding
Awards; or

     (v) Settlement of the full value of the outstanding Awards in cash or cash equivalents
followed by cancellation of such Awards.

     (d) Reservation of Rights. Except as provided in this Section 11, an Optionee or Offeree shall
have no rights by reason of any subdivision or consolidation of shares of stock of any class, the
payment of any dividend or any other increase or decrease in the number of shares of stock of

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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any class. Any issue by the Company of shares of stock of any class, or securities convertible into
shares of stock of any class, shall not affect, and no adjustment by reason thereof shall be made
with respect to, the number or Exercise Price of Shares subject to an Option. The grant of an
Option pursuant to the Plan shall not affect in any way the right or power of the Company to make
adjustments, reclassifications, reorganizations or changes of its capital or business structure, to
merge or consolidate or to dissolve, liquidate, sell or transfer all or any part of its business or
assets.

SECTION 12. DEFERRAL OF AWARDS.

     (a) Committee Powers. The Committee (in its sole discretion) may permit or require a
Participant to:

     (i) Have cash that otherwise would be paid to such Participant as a result of the
exercise of a SAR or the settlement of Stock Units credited to a deferred compensation
account established for such Participant by the Committee as an entry on the Company’s
books;

     (ii) Have Shares that otherwise would be delivered to such Participant as a result of
the exercise of an Option or SAR converted into an equal number of Stock Units; or

     (iii) Have Shares that otherwise would be delivered to such Participant as a result of
the exercise of an Option or SAR or the settlement of Stock Units converted into amounts
credited to a deferred compensation account established for such Participant by the
Committee as an entry on the Company’s books. Such amounts shall be determined by reference
to the Fair Market Value of such Shares as of the date when they otherwise would have been
delivered to such Participant.

     (b) General Rules. A deferred compensation account established under this Section 12 may be
credited with interest or other forms of investment return, as determined by the Committee. A
Participant for whom such an account is established shall have no rights other than those of a
general creditor of the Company. Such an account shall represent an unfunded and unsecured
obligation of the Company and shall be subject to the terms and conditions of the applicable
agreement between such Participant and the Company. If the deferral or conversion of Awards is
permitted or required, the Committee (in its sole discretion) may establish rules, procedures and
forms
pertaining to such Awards, including (without limitation) the settlement of deferred
compensation accounts established under this Section 12.

SECTION 13. AWARDS UNDER OTHER PLANS.

     The Company may grant awards under other plans or programs. Such awards may be settled in the
form of Shares issued under this Plan. Such Shares shall be treated for all purposes under the Plan
like Shares issued in settlement of Stock Units and shall, when issued, reduce the number of Shares
available under Section 5.

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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SECTION 14. PAYMENT OF DIRECTOR’S FEES IN SECURITIES.

     (a) Effective Date. No provision of this Section 14 shall be effective unless and until the
Board has determined to implement such provision.

     (b) Elections to Receive NSOs, Restricted Shares or Stock Units. An Outside Director may elect
to receive his or her annual retainer payments and/or meeting fees from the Company in the form of
cash, NSOs, Restricted Shares or Stock Units, or a combination thereof, as determined by the Board.
Such NSOs, Restricted Shares and Stock Units shall be issued under the Plan. An election under this
Section 14 shall be filed with the Company on the prescribed form.

     (c) Number and Terms of NSOs, Restricted Shares or Stock Units. The number of NSOs, Restricted
Shares or Stock Units to be granted to Outside Directors in lieu of annual retainers and meeting
fees that would otherwise be paid in cash shall be calculated in a manner determined by the Board.
The terms of such NSOs, Restricted Shares or Stock Units shall also be determined by the Board.

SECTION 15. LEGAL AND REGULATORY REQUIREMENTS.

     Shares shall not be issued under the Plan unless the issuance and delivery of such Shares
complies with (or is exempt from) all applicable requirements of law, including (without
limitation) the Securities Act of 1933, as amended, the rules and regulations promulgated
thereunder, state securities laws and regulations and the regulations of any stock exchange on
which the Company’s securities may then be listed, and the Company has obtained the approval or
favorable ruling from any governmental agency which the Company determines is necessary or
advisable. The Company shall not be liable to a Participant or other persons as to: (a) the
non-issuance or sale of Shares as to which the Company has been unable to obtain from any
regulatory body having jurisdiction the authority deemed by the Company’s counsel to be necessary
to the lawful issuance and sale of any Shares under the Plan; and (b) any tax consequences
expected, but not realized, by any Participant or other person due to the receipt, exercise or
settlement of any Award granted under the Plan.

SECTION 16. WITHHOLDING TAXES.

     (a) General. To the extent required by applicable federal, state, local or foreign law, a
Participant or his or her successor shall make arrangements satisfactory to the Company for the
satisfaction of any withholding tax obligations that arise in connection with the Plan. The Company
shall not be required to issue any Shares or make any cash payment under the Plan until such
obligations are satisfied.

     (b) Share Withholding. The Committee may permit a Participant to satisfy all or part of his or
her withholding or income tax obligations by having the Company withhold all or a portion of any
Shares that otherwise would be issued to him or her or by surrendering all or a portion of any
Shares that he or she previously acquired. Such Shares shall be valued at their Fair Market Value
on the date when taxes otherwise would be withheld in cash. In no event may a

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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Participant have
Shares withheld that would otherwise be issued to him or her in excess of the number necessary to
satisfy the legally required minimum tax withholding.

SECTION 17. OTHER PROVISIONS APPLICABLE TO AWARDS.

     (a) Transferability. Unless the agreement evidencing an Award (or an amendment thereto
authorized by the Committee) expressly provides otherwise, no Award granted under this Plan, nor
any interest in such Award, may be sold, assigned, conveyed, gifted, pledged, hypothecated or
otherwise transferred in any manner (prior to the vesting and lapse of any and all restrictions
applicable to Shares issued under such Award), other than by will or the laws of descent and
distribution; provided, however, that an ISO may be transferred or assigned only to the extent
consistent with Section 422 of the Code. Any purported assignment, transfer or encumbrance in
violation of this Section 17(a) shall be void and unenforceable against the Company.

     (b) Qualifying Performance Criteria. The number of Shares or other benefits granted, issued,
retainable and/or vested under an Award may be made subject to the attainment of performance goals
for a specified period of time relating to one or more of the following performance criteria,
either individually, alternatively or in any combination, applied to either the Company as a whole
or to a business unit or Subsidiary, either individually, alternatively or in any combination, and
measured either annually or cumulatively over a period of years, on an absolute basis or relative
to a pre-established target, to previous years’ results or to a designated comparison group or
index, in each case as specified by the Committee in the Award: (a) cash flow, (b) earnings per
share, (c) earnings before interest, taxes and amortization, (d) return on equity, (e) total
stockholder return, (f) share price performance, (g) return on capital, (h) return on assets or net
assets, (i) revenue, (j) income or net income, (k) operating income or net operating income, (l)
operating profit or net operating profit, (m) operating margin or profit margin, (n) return on
operating revenue, (o) return on invested capital, or (p) market segment shares (“Qualifying
Performance Criteria”). The Committee may appropriately adjust any evaluation of performance under
a Qualifying
Performance Criteria to exclude any of the following events that occurs during a performance
period: (i) asset write-downs, (ii) litigation or claim judgments or settlements, (iii) the effect
of changes in tax law, accounting principles or other such laws or provisions affecting reported
results, (iv) accruals for reorganization and restructuring programs and (v) any extraordinary
nonrecurring items as described in Accounting Principles Board Opinion No. 30 and/or in
managements’ discussion and analysis of financial condition and results of operations appearing in
the Company’s annual report to stockholders for the applicable year. If applicable, the Committee
shall determine the Qualifying Performance Criteria not later than the 90th day of the
performance period, and shall determine and certify, for each Participant, the extent to which the
Qualifying Performance Criteria have been met. The Committee may not in any event increase the
amount of compensation payable under the Plan upon the attainment of a Qualifying Performance Goal
to a Participant who is a “covered employee” within the meaning of Section 162(m) of the Code.

SECTION 18. NO EMPLOYMENT RIGHTS.

     No provision of the Plan, nor any right or Option granted under the Plan, shall be construed
to give any person any right to become, to be treated as, or to remain an Employee.

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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The Company and
its Subsidiaries reserve the right to terminate any person’s Service at any time and for any
reason, with or without notice.

SECTION 19. DURATION AND AMENDMENTS.

     (a) Term of the Plan. The Plan, as set forth herein, shall terminate automatically on
September 8, 2015 and may be terminated on any earlier date pursuant to Subsection (b) below.

     (b) Right to Amend or Terminate the Plan. The Board of Directors may amend the Plan at any
time and from time to time. Rights and obligations under any Award granted before amendment of the
Plan shall not be materially impaired by such amendment, except with consent of the Participant. An
amendment of the Plan shall be subject to the approval of the Company’s stockholders only to the
extent required by applicable laws, regulations or rules.

     (c) Effect of Termination. No Awards shall be granted under the Plan after the termination
thereof. The termination of the Plan shall not affect Awards previously granted under the Plan.

[Remainder of this page intentionally left blank]

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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SECTION 20. EXECUTION.

     To record the adoption of the Plan by the Board of Directors, the Company has caused its
authorized officer to execute the same.

	 	 	 	 	 
	 	 	GENOMIC HEALTH, INC.
	 
	 	 	 	 
	 

	 	By	 	 
	 

	 	 	 	 

	 

	 	Name	 	 
	 

	 	 	 	 

	 

	 	Title	 	 
	 

	 	 	 	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

NOTICE OF STOCK OPTION GRANT

     You have been granted the following Option to purchase Common Stock of GENOMIC HEALTH, INC.
(the “Company”) under the Company’s 2005 Stock Incentive Plan (the “Plan”):

	 	 	 
	Name of Optionee:

	 	[Name of Optionee]
	 
	 	 
	Total Number of Option Shares Granted:

	 	[Total Number of Shares]
	 
	 	 
	Type of Option:

	 	o Incentive Stock Option
	 
	 	 
	 

	 	o Nonstatutory Stock Option
	 
	 	 
	Exercise Price Per Share:

	 	$          
	 
	 	 
	Grant Date:

	 	[Date of Grant]
	 
	 	 
	Vesting Commencement Date:

	 	[Vesting Commencement Date]
	 
	 	 
	Vesting Schedule:

	 	This Option becomes exercisable with
respect to the first
1/4th of the shares
subject to this Option when you
complete 12 months of continuous
service as an Employee or a
Consultant from the Vesting
Commencement Date. Thereafter, this
Option becomes exercisable with
respect to an additional
1/48th of the shares
subject to this Option when you
complete each additional month of
such service
	 
	 	 
	Expiration Date:

	 	[Expiration Date] This Option
expires earlier if your Service
terminates earlier, as described in
the Stock Option Agreement.

     By your signature and the signature of the Company’s representative below, you and the Company
agree that this Option is granted under and governed by the term and conditions of the Plan and the
Stock Option Agreement, both of which are attached to and made a part of this document.

     By signing this document you further agree that the Company may deliver by e-mail all
documents relating to the Plan or this award (including without limitation, prospectuses required
by the Securities and Exchange Commission) and all other documents that the Company is required to
deliver to its security holders (including without limitation, annual reports and proxy
statements). You also agree that the Company may deliver these documents by posting them on a
website maintained by the Company or by a third party under contract with the Company. If the
Company posts these documents on a website, it will notify you by e-mail.

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	OPTIONEE:	 	Genomic
Health, Inc.
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 

	Optionee’s Signature
	 	 	 	 
	 
	 	 	 	 
	 

	 	Title:	 	 
	 

	 	 	 	 

	Optionee’s Printed Name
	 	 	 	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

STOCK OPTION AGREEMENT

	 	 	 
	Tax Treatment

	 	This Option is intended to be an incentive stock option under Section 422 of
the Internal Revenue Code or a nonstatutory option, as provided in the Notice
of Stock Option Grant. Even if this Option is designated as an incentive stock
option, it shall be deemed to be a nonstatutory option to the extent required
by the $100,000 annual limitation under Section 422(d) of the Internal Revenue
Code.
	 
	 	 
	Vesting

	 	This Option becomes exercisable in installments, as shown in the Notice of
Stock Option Grant. This Option will in no event become exercisable for
additional shares after your service as an Employee or a Consultant has
terminated for any reason.
	 
	 	 
	Term

	 	This Option expires in any event at the close of business at Company
headquarters on the day before the 10th anniversary of the Grant Date, as shown
on the Notice of Stock Option Grant (fifth anniversary for a more than 10%
stockholder as provided under the Plan if this is an incentive stock option).
This Option may expire earlier if your Service terminates, as described below.
	 
	 	 
	Regular Termination

	 	If your Service terminates for any reason except death or “Total and Permanent
Disability” (as defined in the Plan), then this Option will expire at the close
of business at Company headquarters on the date three (3) months after the date
your Service terminates (or, if earlier, the Expiration Date). The Company has
discretion to determine when your Service terminates for all purposes of the
Plan and its determinations are conclusive and binding on all persons.
	 
	 	 
	Death

	 	If your Service terminates because of death, then this Option will expire at
the close of business at Company headquarters on the date 12 months after the
date your Service terminates (or, if earlier, the Expiration Date). During that
period of up to 12 months, your estate or heirs may exercise the Option.
	 
	 	 
	Disability

	 	If your Service terminates because of your Total and Permanent Disability, then
this Option will expire at the close of business at Company headquarters on the
date 12 months after the date your Service terminates (or, if earlier, the
Expiration Date).
	 
	 	 
	Leaves of Absence

	 	For purposes of this Option, your Service does not terminate when you go on a
military leave, a sick leave or another bona fide leave of absence, if the
leave was approved by the Company in writing and if continued crediting of
Service is required by the terms of the leave or by applicable law. But your
Service terminates when the approved leave ends, unless

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	 	you immediately return to active work.
	 
	 	 
	 

	 	If you go on a leave of absence, then the vesting schedule specified in the
Notice of Stock Option Grant may be adjusted in accordance with the Company’s
leave of absence policy or the terms of your leave. If you commence working on
a part-time basis, then the vesting schedule specified in the Notice of Stock
Option Grant may be adjusted in accordance with the Company’s part-time work
policy or the terms of an agreement between you and the Company pertaining to
your part-time schedule.
	 
	 	 
	Restrictions on

Exercise

	 	The Company will not permit you to exercise this Option if the issuance of
shares at that time would violate any law or regulation. The inability of the
Company to obtain approval from any regulatory body having authority deemed by
the Company to be necessary to the lawful issuance and sale of the Company
stock pursuant to this Option shall relieve the Company of any liability with
respect to the non-issuance or sale of the Company stock as to which such
approval shall not have been obtained. However, the Company shall use its best
efforts to obtain such approval.
	 
	 	 
	Notice of Exercise

	 	When you wish to exercise this Option you must notify the Company by completing
the attached “Notice of Exercise of Stock Option” form and filing it with the
Human Resources Department of the Company. Your notice must specify how many
shares you wish to purchase. Your notice must also specify how your shares
should be registered. The notice will be effective when it is received by the
Company. If someone else wants to exercise this Option after your death, that
person must prove to the Company’s satisfaction that he or she is entitled to
do so.
	 
	 	 
	Form of Payment

	 	When you submit your notice of exercise, you must include payment of the Option
exercise price for the shares you are purchasing. Payment may be made in the
following form(s):

	 	•	 	Your personal check, a cashier’s check or a money order.
	 
	 	•	 	Certificates for shares of Company stock that you own, along
with any forms needed to effect a transfer of those shares to
the Company. The value of the shares, determined as of the
effective date of the Option exercise, will be applied to the
Option exercise price. Instead of surrendering shares of Company
stock, you may attest to the ownership of those shares on a form
provided by the Company and have the same number of shares
subtracted from the Option shares issued to you. However, you
may not surrender, or attest to the ownership of shares of
Company stock in payment of the exercise price if your action
would cause the Company to recognize a compensation expense (or
additional compensation expense) with respect to this Option for
financial reporting purposes.
	 
	 	•	 	By delivery on a form approved by the Committee of an
irrevocable direction to a securities broker approved by the
Company to sell all or

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	 	 	 	part of your Option shares and to deliver
to the Company from the sale proceeds an amount sufficient to
pay the Option exercise price and any withholding taxes. The
balance of the sale proceeds, if any, will be delivered to you.
The directions must be given by signing a special “Notice of
Exercise” form provided by the Company.
	 
	 	•	 	By delivery on a form approved by the Committee of an
irrevocable direction to a securities broker or lender approved
by the Company to pledge Option shares as security for a loan
and to deliver to the Company from the loan proceeds an amount
sufficient to pay the Option exercise price and any withholding
taxes. The directions must be given by signing a special “Notice
of Exercise” form provided by the Company.
	 
	 	•	 	Any other form permitted by the Committee in its sole discretion.

	 	 	 
	 

	 	Notwithstanding the foregoing, payment may not be made in any form that is
unlawful, as determined by the Committee in its sole discretion.
	 
	 	 
	Withholding Taxes
and Stock
Withholding

	 	You will not be allowed to exercise this Option unless you make arrangements
acceptable to the Company to pay any withholding taxes that may be due as a
result of the Option exercise. These arrangements may include withholding
shares of Company stock that otherwise would be issued to you when you exercise
this Option. The value of these shares, determined as of the effective date of
the Option exercise, will be applied to the withholding taxes.
	 
	 	 
	Restrictions on

Resale

	 	By signing this Agreement, you agree not to sell any Option shares at a time
when applicable laws, Company policies or an agreement between the Company and
its underwriters prohibit a sale. This restriction will apply as long as you
are an employee, consultant or director of the Company or a subsidiary of the
Company.
	 
	 	 
	Transfer of Option

	 	In general, only you can exercise this Option prior to your death. You cannot
transfer or assign this Option, other than as designated by you by will or by
the laws of descent and distribution, except as provided below. For instance,
you may not sell this Option or use it as security for a loan. If you attempt
to do any of these things, this Option will immediately become invalid. You may
in any event dispose of this Option in your will. Regardless of any marital
property settlement agreement, the Company is not obligated to honor a notice
of exercise from your former spouse, nor is the Company obligated to recognize
your former spouse’s interest in your Option in any other way.
	 
	 	 
	 

	 	However, if this Option is designated as a nonstatutory stock option in the
Notice of Stock Option Grant, then the Committee may, in its sole discretion,
allow you to transfer this Option as a gift to one or more family members. For
purposes of this Agreement, “family member” means a child, stepchild,
grandchild, parent, stepparent, grandparent, spouse, former spouse, sibling,
niece, nephew, mother-in-law, father-in-law, or

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	 	sister-in-law (including
adoptive relationships), any individual sharing your household (other than a
tenant or employee), a trust in which one or more of these individuals have
more than 50% of the beneficial interest, a foundation in which you or one or
more of these persons control the management of assets, and any entity in which
you or one or more of these persons own more than 50% of the voting interest.
	 
	 	 
	 

	 	In addition, if this Option is designated as a nonstatutory stock option in the
Notice of Stock Option Grant, then the Committee may, in its sole discretion,
allow you to transfer this option to your spouse or former spouse pursuant to a
domestic relations order in settlement of marital property rights.
	 
	 	 
	 

	 	The Committee will allow you to transfer this Option only if both you and the
transferee(s) execute the forms prescribed by the Committee, which include the
consent of the transferee(s) to be bound by this Agreement.
	 
	 	 
	Retention Rights

	 	Neither your Option nor this Agreement gives you the right to be retained by
the Company or a subsidiary of the Company in any capacity. The Company and its
subsidiaries reserve the right to terminate your Service at any time, with or
without cause.
	 
	 	 
	Stockholder Rights

	 	You, or your estate or heirs, have no rights as a stockholder of the Company
until you have exercised this Option by giving the required notice to the
Company and paying the exercise price. No adjustments are made for dividends or
other rights if the applicable record date occurs before you exercise this
Option, except as described in the Plan.
	 
	 	 
	Adjustments

	 	In the event of a stock split, a stock dividend or a similar change in Company
stock, the number of shares covered by this Option and the exercise price per
share may be adjusted pursuant to the Plan.
	 
	 	 
	Applicable Law

	 	This Agreement will be interpreted and enforced under the laws of the State of
Delaware (without regard to their choice-of-law provisions).
	 
	 	 
	The Plan and Other
Agreements

	 	The text of the Plan is incorporated in this Agreement by reference. All
capitalized terms in the Stock Option Agreement shall have the meanings
assigned to them in the Plan. This Agreement and the Plan constitute the entire
understanding between you and the Company regarding this Option. Any prior
agreements, commitments or negotiations concerning this Option are superseded.
This Agreement may be amended only by another written agreement, signed by both
parties.

BY SIGNING THE COVER SHEET OF THIS AGREEMENT,

YOU AGREE TO ALL OF THE TERMS AND CONDITIONS

DESCRIBED ABOVE AND IN THE PLAN.

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

NOTICE OF EXERCISE OF STOCK OPTION

You must sign this Notice on the last page before submitting

it to the Company

OPTIONEE INFORMATION:

	 	 	 	 	 	 	 
	Name:

	 	 	 	Social Security Number:	 	 
	 

	 	 

	 	 	 	 

	Address:

	 	 	 	Employee Number:	 	 
	 

	 	 

	 	 	 	 

OPTION INFORMATION:

	 	 	 
	Date of Grant:           , 200___

	 	Type of Stock Option:
	Exercise Price per Share: $     

	 	o     Nonstatutory (NSO)
	Total number of shares of Common Stock of
Genomic Health, Inc. (the “Company”)
covered by option:      

	 	o     Incentive (ISO)

EXERCISE INFORMATION:

Number of shares of Common Stock of the Company for which option is being exercised now: 
. (These shares are referred to below as the “Purchased Shares.”)

Total exercise price for the Purchased Shares: $     

Form of payment enclosed [check all that apply]:

	o	 	Check for $     , payable to “GENOMIC HEALTH, INC.”
	 
	o	 	Certificate(s) for     shares of Common Stock of the Company
that I have owned for at least six months or have purchased in the open
market. (These shares will be valued as of the date when the Company
receives this notice.)
	 
	o	 	Attestation Form covering     shares of Common Stock
of the Company. (These shares will be valued as of the date when the
Company receives this notice.)

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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Name(s) in which the Purchased Shares should be registered

[please check one box]:

	 	 	 	 	 
	o

	 	In my name only	 	 
	 
	 	 	 	 
	o

	 	In the names of my
	 	My spouse’s name (if applicable):
	 

	 	spouse and myself as
community property
	 	 

	 
	 	 	 	 
	o

	 	In the names of my
spouse and myself as
joint tenants with
the right of
survivorship	 	 
	 
	 	 	 	 
	o

	 	In the name of an
	 	Full legal name of revocable trust:
	 

	 	eligible revocable

trust
	 	 

	 

	 	 	 	 

	 

	 	 	 	 	 	 	 

	The certificate for the Purchased
Shares should be sent to the
following address:	 	 

	 

	 	 	 	 

ACKNOWLEDGMENTS:

	1.	 	I understand that all sales of Purchased Shares are subject to
compliance with the Company’s policy on securities trades.
	 
	2.	 	I hereby acknowledge that I received and read a copy of the prospectus
describing the Company’s 2005 Stock Incentive Plan and the tax
consequences of an exercise.
	 
	3.	 	In the case of a nonstatutory option, I understand that I must
recognize ordinary income equal to the spread between the fair market
value of the Purchased Shares on the date of exercise and the exercise
price. I further understand that I am required to pay withholding taxes
at the time of exercising a nonstatutory option.
	 
	4.	 	In the case of an incentive stock option, I agree to notify the Company
if I dispose of the Purchased Shares before I have met both of the tax
holding periods applicable to incentive stock options (that is, if I
make a disqualifying disposition).
	 
	5.	 	I acknowledge that the Company has encouraged me to consult my own
adviser to determine the form of ownership that is appropriate for me.
In the event that I choose to transfer my Purchased Shares to a trust
that does not satisfy the requirements of the Internal Revenue Service
(i.e., a trust that is not an eligible revocable trust), I also
acknowledge that the transfer will be treated as a “disposition” for
incentive stock option tax purposes. As a result, the favorable
incentive stock option tax treatment will be unavailable and other
unfavorable tax consequences may occur.

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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	SIGNATURE AND DATE:
	 	 	 	 
	 
	 	 	 	 
	 

	 	  _____________
  ___, 200_
	 	 
	 
	 	 	 	 

GENOMIC HEALTH, INC.

2005 STOCK INCENTIVE PLAN

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