Document:

EX-10.7

 Exhibit 10.7 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(c) and Rule 406 of the 

Securities Act of 1933, as amended. 
  

 
 LICENSE AGREEMENT 

by and between 
 THE
SCRIPPS RESEARCH INSTITUTE, 
 a California nonprofit 

public benefit corporation 

and 
 SYNTHORX, INC.,

 a Delaware corporation 

 LICENSE AGREEMENT 

THIS LICENSE AGREEMENT is entered into and made effective
as of this 31st day of July, 2014 (the “Effective Date”), by and between THE SCRIPPS RESEARCH
INSTITUTE, a California nonprofit public benefit corporation (“TSRI”) located at 10550 North Torrey Pines Road, La Jolla, California 92037, and SYNTHORX,
INC., a Delaware corporation (“Licensee”) located at 11099 North Torrey Pines Road, Suite 290, La Jolla, California 92037, with respect to the facts set forth below. 

RECITALS 

A.        TSRI is engaged in fundamental scientific biomedical and biochemical
research including research relating to synthetic DNA bases. 
 B.        Licensee
is engaged in research and development of novel molecules for the prevention, diagnosis and/or treatment of diseases. 

C.        TSRI has disclosed to Licensee certain technology and TSRI has the right to
grant a license to the technology, subject to certain rights of the U.S. Government resulting from the receipt by TSRI of certain funding from the U.S. Government. 

D.        TSRI desires to grant to Licensee, and Licensee wishes to acquire from TSRI,
an exclusive worldwide right and license to certain patent rights and materials of TSRI, subject to the terms and conditions set forth herein. 

E.        TSRI and Licensee are parties to that certain Research Funding and Option
Agreement dated as of the Effective Date (the “RFOA”), pursuant to which: (i) Licensee is providing certain funding to TSRI to support research related to synthetic DNA bases and synthetic nucleotides, including the use
thereof to re-engineer living cells; and (ii) the parties have agreed that Licensee has an exclusive option to license all Patent Rights and Technology (as such terms are defined in the RFOA) arising
under the RFOA on the terms and conditions set forth in this Agreement. 
 NOW,
THEREFORE, in consideration of the mutual covenants and conditions set forth herein, TSRI and Licensee hereby agree as follows: 
  

	1.	 Definitions. Capitalized terms shall have the meaning set forth herein. 

1.1        Affiliate. The term “Affiliate” shall mean any entity
which directly or indirectly controls, or is controlled by Licensee. The term “control” as used herein means (a) in the case of corporate entities, direct or indirect ownership of at least 50% of the stock or shares entitled to vote
for the election of directors; or (b) in the case of non-corporate entities, direct or indirect ownership of at least 50% of the equity interest with the power to direct the management and policies of
such non-corporate entities. 

1.2        Challenge. Licensee will be deemed to have made a
“Challenge” of the Licensed Patent Rights if Licensee or a Sublicensee: (a) institutes, or causes its counsel to institute on 

  
 1 

 
Licensee’s or such Sublicensee’s behalf, any interference, opposition, re-examination or similar proceeding with respect to any Licensed Patent Right with the U.S. Patent and Trademark
Office or any foreign patent office; or (b) makes any filing or institutes any legal proceeding, or causes its counsel to make any filing or institute any legal proceeding on Licensee’s or such Sublicensee’s behalf, with a court or other
governmental body (including, without limitation, the U.S. Patent and Trademark Office or any foreign patent office) in which one or more claims or allegations challenges the validity or enforceability of any Licensed Patent Right; provided,
however, that, any such action described in subsection (a) and/or (b) by a Sublicensee shall not be deemed to be a Challenge if Licensee promptly terminates the agreement granting such Sublicensee a sublicense with respect to the Licensed Patent
Rights in accordance with the terms of such agreement. 
 1.3        Commercial
Partner. The term “Commercial Partner” shall mean any Third Party distribution or marketing partner to whom Licensee or its Affiliate grants distribution or marketing rights (other than a sublicense) under the Licensed Technology. 

1.4        Company Product. The term “Company Product” shall mean any
compound or product that is identified, generated or developed internally by Licensee (i.e., not pursuant to any partnership or collaboration with any Third Party) through the use of the Licensed Technology, which compound or product:
(a) is covered by a Valid Claim of patent rights owned or controlled by Licensee independently of this Agreement (i.e., excluding the Licensed Patent Rights); and (b) is not itself a Licensed Product. For clarity, and
notwithstanding the preceding sentence, Company Products specifically exclude any Derived Product with respect to which Licensee or its Affiliate has granted a Third Party a license or other distribution or marketing rights. 

1.5        Confidential Information. The term “Confidential
Information” shall mean any and all proprietary or confidential information of TSRI or Licensee that such party (the “Disclosing Party”) discloses to the other party (the “Receiving Party”) at any
time and from time to time during the term of this Agreement. Information shall not be considered confidential to the extent that the Receiving Party can establish by competent proof that it: 

(a)        Is publicly disclosed through no fault of the Receiving Party, either
before or after it becomes known to the Receiving Party; 
 (b)        Was known to
the Receiving Party prior to the date of this Agreement, which knowledge was acquired independently and not from another party hereto (or such party’s employees); 

(c)        Is subsequently disclosed to the Receiving Party in good faith by a Third
Party who is not under any obligation to maintain the confidentiality of such information, and without breach of this Agreement by the Receiving Party; 

(d)        Has been published by a Third Party as a matter of right; or 

(e)        Is independently developed by the Receiving Party’s employees who
have not had access to the Disclosing Party’s Confidential Information and without any use of or reliance upon information received from the Disclosing Party, as evidenced by the Receiving Party’s written records. 

  
 2 

 1.6        Conversion Date.
The term “Conversion Date” shall mean the earlier of [...***...]. 

1.7        Derived Product. The term “Derived Product” shall mean any
compound or product that is generated, identified or developed by Licensee or its Affiliate through the use of the Licensed Technology, but which itself is not a Licensed Product. 

1.8        Derived Technology. The term “Derived Technology” shall
mean any invention (whether or not patentable), technology or know-how generated, identified or developed by Licensee or its Affiliate through the use of the Licensed Technology, but which itself is neither
covered by the Licensed Patent Rights nor within the Licensed Technology. 

1.9        Field. The term “Field” shall mean [...***...]. 

1.10      Initiation. The term “Initiation” shall mean, with respect to a
clinical trial, the first dosing of the first subject in such trial. 
 1.11      Licensed
Biological Materials. The term “Licensed Biological Materials” shall mean the materials supplied by TSRI (identified in Exhibit A, as updated from time to time in accordance with this Agreement), together with
any progeny, mutants, or derivatives thereof supplied by TSRI or created by Licensee. At Licensee’s request from time to time, the parties shall cooperate in good faith to amend Exhibit A to add biological materials
arising under the RFOA that constitute “Technology” (including, without limitation, “Joint Technology”), as such terms are defined in the RFOA, which shall be signed by both parties, attached as
Exhibit A to this Agreement, and incorporated herein by this reference. 
 1.12      Licensed Know-How. The term “Licensed Know-How” shall mean only the unpatented information and data described in Exhibit B that is within the possession of the laboratory of Dr. Floyd E. Romesberg at TSRI, as
Exhibit B may be amended from time to time. At Licensee’s request from time to time, the parties shall cooperate in good faith to update Exhibit B to add unpatented information and data
arising under the RFOA that constitute “Technology” (including, without limitation, “Joint Technology”), as such terms are defined in the RFOA, which shall be signed by both parties, attached as
Exhibit B to this Agreement, and incorporated herein by this reference. 
 1.13      Licensed Patent Rights. The term “Licensed Patent Rights” shall mean: 

(a)        the patent(s) and patent application(s) listed in
Exhibit C, as Exhibit C may be amended from time to time; 

(b)        the foreign counterpart patents and applications of the respective patents
and applications referenced in sub-clause (a) above, but only to the extent the claims of such patents or applications are entitled to the priority date of the respective applications referenced in sub-clause (a) above; 

  
 ***Confidential
Treatment Requested 
  
 3 

 (c)        divisionals,
substitutions, and continuations of any applications referenced in sub-clauses (a) and (b) above; 

(d)        any claim(s) of a pending or issued continuation-in-part of any application set forth in sub-clauses (a)-(c) above that are entitled to the priority date of the respective application(s)
referenced in sub-clause (a) above; and 

(e)        the patents issued from the applications referenced in sub-clauses (a)-(d) above and any reissues, reexaminations, renewals and patent term extensions of such patents. 

At Licensee’s request from time to time, and in any event promptly after the filing of any patent application within the
“Patent Rights” (as defined in the RFOA) arising under the RFOA, the parties shall cooperate in good faith to compile a then-current list of the existing Licensed Patents, which shall be signed by both parties, attached as
Exhibit C to this Agreement, and incorporated herein by this reference. 

1.14    Licensed Product. The term “Licensed Product” shall mean any compound or product,
the manufacture, use, sale, offer for sale or importation of which would, in the absence of the license under the Licensed Patent Rights granted in this Agreement, infringe a Valid Claim of the Licensed Patent Rights. 

1.15    Licensed Technology. The term “Licensed Technology” shall mean the Licensed
Patent Rights, Licensed Know-How and Licensed Biological Materials. 

1.16    Net Sales. The term “Net Sales” shall mean the gross amounts invoiced by
(i) Licensee or its Affiliates or Sublicensees to Third Parties on sales of Licensed Products, or (ii) Licensee or its Affiliates to Third Parties on sales of Company Products; in each case, less the following items, to the extent
attributable to such sales of Products (if not previously deducted from the amount invoiced): (a) [...***...]; (b) [...***...]; (c) [...***...]; (d) [...***...]; (e) [...***...];
(f) [...***...]; and (g) [...***...]. 
 Net Sales shall include all consideration charged by
Licensee, its Affiliate, or, solely in the case of Licensed Products, a Sublicensee (in each case, a “Selling Party”), in exchange for any Products, including without limitation any monetary payments or, with regard to any
other property paid in exchange for any Products an amount in cash equal to the fair market value of such property. For purposes of determining Net Sales, a sale shall be deemed to have occurred when an invoice therefor shall be generated or the
Product is shipped for delivery. Sales of Products by one Selling Party to another Selling Party for resale shall be excluded, and only the 

  
 ***Confidential
Treatment Requested 
  
 4 

 
subsequent sale of such Products to unrelated parties shall be included in the calculation of Net Sales hereunder. 

The deductible items listed in sub-clauses (a)-(g) above shall be either
(i) included as line items on the invoice, or (ii) reasonably supported by other appropriate documentation as being specifically attributable to sales of Products in accordance with United States Generally Accepted Accounting Principles
(“GAAP”) or International Financing Reporting Standards (“IFRS”), as applicable, consistently applied throughout the organization of the Selling Party; and such amounts shall be included in the
quarterly Royalty Reports that Licensee sends to TSRI pursuant to Section 6.3. If Licensee or another Selling Party receives refunds or reimbursements of any amounts deducted as set forth herein, then such refunded or reimbursed amounts shall
be considered Net Sales in the applicable reporting period in which such refunded or reimbursed amounts are received. 

Products distributed as free promotional samples or in any compassionate use program, donated to non-profit institutions or government agencies, in which, in each case, no monetary or other consideration is paid to or received by the Selling Party, and Products used in research or development activities,
including, without limitation, clinical trials, shall be disregarded in determining Net Sales. 

1.17    Non-Sublicensing Transaction
Revenues.        The term “Non-Sublicensing Transaction Revenues” shall mean all amounts actually received by Licensee and its Affiliates prior to the
Conversion Date from any Third Party licensee or Third Party distribution or marketing partner, in consideration of: (a) the grant by Licensee or its Affiliate to such Third Party of a license to the Derived Technology or to the Derived
Products, or (b) the grant of other distribution or marketing rights with respect to Derived Products (in each case, a “Non-Sublicensing
Transaction”). Without limiting the generality of the foregoing, Non-Sublicensing Transaction Revenues shall include, without limitation, all
up-front fees, license fees, royalties on sales of Derived Products, milestone payments, technology access fees, premiums above the fair market value on sales of debt or equity securities of Licensee or its
Affiliate, annual maintenance fees, and any other payments actually received by Licensee or its Affiliate prior to the Conversion Date with respect to such Non-Sublicensing Transaction. Non-Sublicensing Transaction Revenues include amounts received from a Third Party licensee or Third Party distribution or marketing partner under the terms of the agreement effecting the Non-Sublicensing Transaction are granted and under the terms of other agreements entered into between Licensee or its Affiliate and such Third Party as part of the same transaction as the agreement effecting the Non-Sublicensing Transaction. However, Non-Sublicensing Transaction Revenues shall exclude: (i) [...***...]; (ii) [...***...];
(iii) [...***...]; and (iv) [...***...] 

  
 ***Confidential
Treatment Requested 
  
 5 

 [...***...]. Any non-cash Non-Sublicensing Transaction Revenues received by Licensee or its Affiliate from a Third Party licensee or Third Party distribution or marketing partner shall be valued at its fair market value as of the date of
receipt. For clarity, no amount included in the calculation of Sublicensing Revenues shall be included in the calculation of Non-Sublicensing Transaction Revenues, nor shall any amount included in the
calculation of Non-Sublicensing Transaction Revenues be included in the calculation of Sublicensing Revenues. 

1.18    Phase 1 Trial. The term “Phase 1 Trial” shall mean a
human clinical trial that would satisfy the requirements for a Phase 1 study as defined in 21 CFR § 312.21(a) (or its successor regulation). 

1.19    Phase 3 Trial. The term “Phase 3 Trial” shall mean a
human clinical trial that would satisfy the requirements for a Phase 3 study as defined in 21 CFR § 312.21(c) (or its successor regulation). 

1.20    Product. The term “Product” shall mean a Licensed Product and/or a Company
Product, as applicable. 
 1.21    Sublicensing Revenues. The term “Sublicensing
Revenues” shall mean all amounts actually received by Licensee and its Affiliates from any Sublicensee or Commercial Partner, in consideration of the grant by Licensee or its Affiliate of a sublicense or other distribution or marketing rights
under the Licensed Technology. Without limiting the generality of the foregoing, Sublicensing Revenues shall include, without limitation, all up-front fees, license fees, milestone payments, technology access
fees, premiums above the fair market value on sales of debt or equity securities of Licensee or of an Affiliate, annual maintenance fees, and any other payments with respect to the grant of a sublicense or distribution or marketing rights.
Sublicensing Revenues include amounts received from a Sublicensee or Commercial Partner under the terms of the agreement in which the sublicense or other distribution or marketing rights are granted and under the terms of other agreements entered
into between Licensee or its Affiliate and the Sublicensee or Commercial Partner as part of the same transaction as the agreement that includes the grant of the sublicense or other distribution or marketing rights. However, Sublicensing Revenues
shall exclude: (i) [...***...]; (ii) [...***...]; (iii) [...***...]; and (iv) [...***...] 

  
 ***Confidential
Treatment Requested 
  
 6 

 [...***...]. 

1.22    Sublicensee. The term “Sublicensee” shall mean any Third Party to whom Licensee
or its Affiliate grants a sublicense with respect to the rights conferred upon Licensee under this Agreement, as permitted by Section 2.2 and any and all further Third Party sublicensees under Section 2.2. 

1.23    Third Party. The term “Third Party” shall mean any entity other than TSRI or
Licensee or any of their respective Affiliates. 
 1.24    Valid Claim. The term “Valid
Claim” shall mean a claim of an issued patent that has not lapsed, expired, been canceled, or become abandoned, and has not been held invalid by a court or other appropriate body of competent jurisdiction, unappealable or unappealed within the
time allowed for appeal and which has not been admitted to be invalid or unenforceable through reissue or disclaimer or otherwise. The term “Valid Claim” shall also include the claims of a pending patent application which have not been
pending for a period of more than [...***...] ([...***...]) years from the date of the first examination on the merits of that patent application. 
  

	2.	 Grant of License. 

2.1        Grant of License for Products. TSRI hereby grants and Licensee
accepts, subject to the terms and conditions of this Agreement, an exclusive (except as set forth in Sections 2.4 and 2.5), worldwide, royalty-bearing license under the Licensed Technology to make, have made, use, have used, sell, have sold,
offer for sale and import Products and Derived Products in the Field and otherwise to exploit the Licensed Technology in the Field. 

2.2        Sublicensing. Licensee shall have the right to grant sublicenses
(through multiple tiers of sublicense) with respect to the rights conferred upon Licensee under this Agreement; provided, however, that any such sublicense shall be subject in all respects to the provisions contained in this Agreement
(including without limitation the provisions regarding governmental interest, reservation of rights, development efforts, reporting, audit rights, indemnity, warranty disclaimer, limitation of liability, confidentiality, and rights upon expiration
or termination, but excluding the payment of a License Issue Royalty and the issuance of equity securities). In the event of a conflict between this Agreement and the terms of any sublicense, the terms of this Agreement shall control. Licensee shall
forward to TSRI a copy of any and all fully executed sublicense agreements within [...***...] of execution. Licensee shall at all times be and remain responsible for the compliance of Sublicensees with the terms and conditions of this
Agreement, including without limitation payment of all amounts that may become due hereunder as a result of Sublicensees’ activities. 

2.3        No Other License. This Agreement confers no license or rights by
implication, estoppel, or otherwise under any patent applications or patents of TSRI other than the Licensed Patent Rights regardless of whether such patents are dominant or subordinate to the Licensed Patent Rights. 

2.4        Governmental Interest. Licensee and TSRI acknowledge that TSRI has
received, and expects to continue to receive, funding from the United States Government in support of 

  
 ***Confidential
Treatment Requested 
  
 7 

 
TSRI’s research activities. Licensee and TSRI acknowledge and agree that, to the extent the Licensed Technology arises or results from TSRI’s receipt of research support from the United
States Government, their respective rights and obligations pursuant to this Agreement shall be subject to the rights of the United States Government, existing and as amended, including but not limited to, 37CFR401, the NIH Grants Policy Statement
and the NIH Guidelines for Obtaining and Disseminating Biomedical Research Resources. 

2.5        Reservation of Rights. Notwithstanding the exclusive licenses
granted herein to the Licensed Technology, TSRI reserves the right to [...***...]. In addition, TSRI reserves the right to [...***...]. Upon Licensee’s written request from time to time, TSRI agrees to disclose to Licensee the
identities of [...***...]. 
  

	3.	 Royalties 

3.1        License Issue Royalty. Licensee agrees to pay and shall pay to TSRI
a non-creditable, non-refundable license issue royalty in the amount of US$[...***...] within [...***...] after the Effective Date. Failure of Licensee to
make this payment shall render this Agreement null and void (ab initio). 

3.2        Equity Issuances. 

3.2.1    Subject to the provisions of this Section 3.2, within [...***...] after the Effective
Date, Licensee shall issue to TSRI 49,130 shares of Licensee’s common stock, which represents [...***...]% of the Outstanding Shares of Licensee, on an as-converted-to-common basis, as of the Effective Date (the “Initial Issuance”). For purposes of this Section 3.2, the term
“Outstanding Shares” shall mean, as of a given date, the sum of: (a) the number of shares of Licensee’s common stock outstanding as of such date (including the shares of Licensee common
stock to be issued to TSRI on such date); (b) the number of shares of Licensee’s common stock into which all outstanding shares of Licensee’s preferred stock as of such date could be converted if fully converted on the day immediately
preceding such date; (c) the number of shares of Licensee’s common stock into which any warrant or other right to subscribe for or purchase any common stock or preferred stock of Licensee outstanding as of such date could be converted if
fully exercised and converted on the day immediately preceding such date, and (d) the number of shares of Licensee’s common stock issuable upon exercise of all options to purchase Licensee’s common stock outstanding as of such date of
Licensee if fully exercised on the day immediately preceding such date. 
 3.2.2    In addition, after
the Initial Issuance and until such time as Licensee has raised at least an aggregate of $[...***...] in gross proceeds in one or more equity financings 

  
 ***Confidential
Treatment Requested 
  
 8 

 
(inclusive of the gross proceeds raised by Licensee in its Series A Preferred Stock equity financing as of the Effective Date), Licensee shall issue to TSRI concurrently with the closing of any
equity financing of Licensee (each, a “Financing Closing”), such additional number of shares of Licensee’s common stock [...***...]% of the Outstanding Shares as of the date of such Financing Closing; provided,
however, that if the gross proceeds of any Financing Closing, together with the gross proceeds of all preceding Financing Closings plus the gross proceeds raised by Licensee in its Series A Preferred Stock equity financing as of the Effective
Date, exceed $[...***...], Licensee shall only be obligated to issue to TSRI and, subject to compliance with applicable securities laws, to TSRI’s transferees, such additional number of shares of Licensee’s common stock
[...***...]% of the Outstanding Shares for the first $[...***...] in gross proceeds. Licensee’s obligations and TSRI’s rights under this Section 3.2.2 shall apply only to Financing Closings consummated before the earlier
of [...***...]. 
 3.2.3    Licensee shall deliver to TSRI stock certificate(s) representing the
shares issued to TSRI in connection with any Financing Closing within [...***...] after such Financing Closing. Licensee’s obligation (a) to issue and deliver such shares of common stock to TSRI in connection with the Initial
Issuance or any Financing Closing and (b) in the event of TSRI’s transfer of such shares in accordance with the stock issuance agreement entered into by TSRI and Licensee in connection with the Initial Issuance or any Financing Closing, to
record such transfer and reissue stock certificate(s) representing the transferred shares to TSRI’s transferees, is contingent upon TSRI’s or its transferee’s (as applicable) execution and delivery to Licensee of a stock issuance
agreement in substantially the form attached hereto as Exhibit D (a “Stock Issuance Agreement”), and is subject to applicable securities laws. Subject to the preceding sentence, Licensee’s
failure to issue shares to TSRI and TSRI’s transferees in accordance with this Section 3.2 shall render this Agreement null and void (ab initio). 

3.2.4    If Licensee proposes to sell or sells any Equity Securities after such time as Licensee has
raised at least an aggregate of $[...***...] in gross proceeds in one or more equity financings (inclusive of the gross proceeds raised by Licensee in its Series A Preferred Stock equity financing as of the Effective Date and the gross
proceeds of any additional closing of such Series A Preferred Stock equity financing after the Effective Date), in each instance, TSRI and/or its Assignee (defined below) shall have the right, but not the obligation, to purchase for cash up to
[...***...]. For purposes of this Section 3.2.4, the term “Assignee” means (i) any entity to which TSRI’s pre-emptive rights hereunder have been assigned, or (ii) any entity
that is controlled by TSRI.
 3.3        Minimum Annual Royalty. Commencing
[...***...] after the Effective Date, Licensee agrees to pay and shall pay to TSRI a nonrefundable minimum annual royalty in the amount of US$[...***...]. The first payment is due upon the [...***...],

  
 ***Confidential
Treatment Requested 
  
 9 

 
and each subsequent payment is due upon [...***...] thereafter until [...***...] and Royalty Reports shall reflect such a credit. Such payments shall [...***...]. 

3.4        Running Royalties for Products. Licensee agrees to pay and shall pay
to TSRI running royalties on a country-by-country and Product-by-Product basis as
follows: 
 (a)        [...***...]% of Net Sales of each Licensed Product by
Licensee, its Affiliates or Sublicensees; and 
 (b)        [...***...]% of
Net Sales of each Company Product by Licensee or its Affiliates. 
 For clarity, [...***...], and TSRI’s sole
compensation with respect to sales of Derived Products shall be as set forth in Section 4.3. 

3.5        Multiple Royalties. No multiple royalties shall be due because any
Licensed Product is covered by more than one of the Licensed Patent Rights. 

3.6        Arms-Length Transactions. On sales of Products which are made in
other than an arm’s-length transaction, the value of the Net Sales attributed under this Section 3 to such a transaction shall be [...***...], based on sales of like quality and quantity
products on or about the time of such transaction. 
 3.7        Royalty
Credit. If Licensee is required, upon the advice of patent counsel, to obtain a license under patent rights held by a Third Party that would, in the absence of such license, be infringed by Licensee’s practice of the inventions claimed by
the Licensed Patent Rights in the manufacture, use or sale of a Licensed Product, then Licensee shall be entitled to deduct from the royalties due to TSRI under Section 3.4(a) with respect to sales of that Licensed Product [...***...]% of
the royalties Licensee actually paid to such Third Party in that reporting period, provided that the royalties payable to TSRI with respect to such Licensed Product in such country may not be reduced by more than [...***...]% in any calendar
quarter as a result of any and all such offsets in the aggregate. Licensee shall not be entitled to any Third Party royalty credit with respect to sales of Company Products. 

3.8        Payment Increase. Notwithstanding Section 3.4(a), in the event
Licensee, an Affiliate or a Sublicensee directly or indirectly institutes or makes any Challenge, all of the payment obligations under this Section 3 (excluding Sections 3.1, 3.2 and 3.4(b)) and under Section 4 (excluding
Section 4.3) of this Agreement shall be [...***...] during the pendency of such Challenge from the date such challenging party first institutes or makes such Challenge and during the pendency of such Challenge, and shall continue to apply
after the conclusion of such Challenge in the event that at least one Valid Claim that covers a Licensed Product is held to be valid and enforceable. 

  
 ***Confidential
Treatment Requested 
  
 10 

 3.9        Pre-Challenge Requirements. Licensee will provide written notice to TSRI at least [...***...] prior to Licensee or an Affiliate instituting or making any Challenge. Licensee will include with such written
notice a list of all prior art and a description of the other facts and arguments that support its contention that any of the Licensed Patent Rights are invalid or unenforceable. During such [...***...] period, the parties will discuss the
same and attempt in good faith to mutually resolve such issues. 
 3.10    Duration of Royalty
Obligations. The royalty obligations of Licensee as to each Licensed Product shall terminate on a country-by-country basis upon the expiration of the last-to-expire Valid Claim of the Licensed Patent Rights that covers such Licensed Product in such country. The royalty obligations of Licensee as to each Company Product
shall terminate on a country-by-country basis upon the last-to-expire Valid Claim of
patent rights owned or controlled by Licensee that covers such Company Product in such country. 

3.11    No Right to Recoup Payments. In the event Licensee, an Affiliate or Sublicensee directly or
indirectly institutes or makes any Challenges, Licensee shall have no right to recoup, recover, set off or otherwise get reimbursement of any royalties, Sublicense Payments, milestone payments, equity issuances, patent costs or other monies paid
hereunder to TSRI [...***...]. Licensee hereby voluntarily and irrevocably waives any right to seek return of such royalties, Sublicense Payments, equity issuances, milestone payments, patent costs or other monies in the event Licensee, an
Affiliate or Sublicensee directly or indirectly institutes or makes any Challenges. 

3.12    Combination Products. If a Licensed Product is sold in any country in combination with
another active ingredient that is not a Licensed Product (a “Combination Product”), Net Sales of the Licensed Product portion of such Combination Product shall be calculated by [...***...].
If either the Licensed Product or the other active ingredient(s) are not sold separately during that royalty period, or such average sale price cannot be determined for both the Licensed Product, when sold separately from the other active
ingredient(s), and the other active ingredient(s), then the Net Sales of such Licensed Product portion of the Combination Product for purposes of determining royalty payments shall be [...***...], which agreement shall not be unreasonably
withheld or delayed. Notwithstanding anything to the contrary herein, the royalty paid to TSRI on Net Sales of the Licensed Product portion of a Combination Product shall not be less than [...***...]% of the royalty that would otherwise be due
on such Licensed Product under Section 3.4(a) above. 

  
 ***Confidential
Treatment Requested 
  
 11 

	4.	 Non-Royalty Revenues. 

4.1        Sublicense Payments. Licensee shall pay to TSRI a non-refundable, non-creditable percentage of Sublicensing Revenues according to the following schedule (“Sublicense
Payments”): 
  

			
	 Date of Sublicense Grant
	  	    Percentage of Sublicensing    
Revenues to TSRI
		
	Prior to Licensee’s expenditures exceeding US$[...***...] and on or before the [...***...]	  	[...***...]%
		
	Prior to Licensee’s expenditures exceeding US$[...***...] and after the [...***...]	  	[...***...]%
		
	At any time after the earlier of Licensee’s expenditures exceeding US$[...***...] and [...***...]	  	[...***...]%

 4.2        Licensed Product Development
Milestones. Licensee agrees to pay and shall pay to TSRI the following non-creditable, non-refundable Licensed Product development milestones specified below within
[...***...] of the first achievement of each milestone event by each Licensed Product (and only for milestone events achieved by Licensee or its Affiliate, and not by a Sublicensee) as follows: 

 

			
	 Milestone Event
	  	    Milestone Payment    
		
	[...***...]	  	US$[...***...]%
		
	[...***...]	  	US$[...***...]%
		
	[...***...]	  	US$[...***...]%

 For clarification, each of the foregoing milestone payments shall be payable only one time for each Licensed
Product that is or contains a particular chemical entity as an active ingredient, and only with respect to the first achievement of the applicable milestone by a Licensed Product comprising or containing that same chemical entity, regardless of the
number of Licensed Products comprising or containing that same chemical entity that achieve such milestone. 

4.3        Non-Sublicensing Transaction
Revenues. 
 4.3.1    On the Conversion Date, subject to TSRI’s execution of a reasonable
stock issuance agreement and, to the extent requested by Licensee, TSRI’s execution of any voting 

  
 ***Confidential
Treatment Requested 
  
 12 

 
agreement among Licensee and holders of Licensee’s preferred stock (“Preferred Stock”), Licensee shall issue to TSRI that number of shares of the most recently issued
series of Licensee’s Preferred Stock determined by [...***...]; provided, however, that immediately after such issuance, TSRI’s and its Assignee’s(s’) collective equity ownership interest in Licensee (including the
shares issued to TSRI on the Conversion Date, all shares previously issued to TSRI pursuant to Section 3.2, and all Equity Securities purchased by TSRI and/or its Assignee pursuant to Section 3.2.4), on a fully-diluted, as-converted basis,
shall not exceed [...***...]%. 
 4.3.2    For purposes of Section 4.3.1, TSRI’s share
of Non-Sublicensing Transaction Revenues received prior to the Conversion Date will be determined based on when the applicable Non-Sublicensing Transaction (as defined
in Section 1.17) is entered into in relation to Licensee’s cumulative expenditures (i.e., operating expenses) from inception and in relation to the Effective Date, as follows: 

 

			
	 Date of Non-Sublicensing Transaction
	  	    TSRI Share of Non-Sublicensing    
Transaction Revenues
		
	Prior to Licensee’s cumulative expenditures exceeding US$[...***...] and on or before [...***...]	  	[...***...]%
		
	Prior to Licensee’s cumulative expenditures exceeding US$[...***...] and after the [...***...]	  	[...***...]%
		
	At any time after the earlier of Licensee’s cumulative expenditures exceeding US$[...***...] and [...***...]	  	[...***...]%

 For clarity, TSRI shall not be entitled to any cash payment in respect of any
Non-Sublicensing Transaction Revenues, and TSRI will receive its applicable share of Non-Sublicensing Transaction Revenues solely as a
one-time issuance of shares of Preferred Stock on the Conversion Date as set forth above in this Section 4.3. 
  

	5.	 Royalty Payments and Sublicense Payments. 

Royalties on Net Sales of Licensed Products by Licensee, its Affiliates and Sublicensees and Net Sales of Company Products by
Licensee and its Affiliates pursuant to Section 3.4, and Sublicense Payments pursuant to Section 4.1 shall be payable to TSRI on quarterly basis within [...***...] after the end of each calendar quarter, based on Net Sales of
Licensed Products by 

  
 ***Confidential
Treatment Requested 
  
 13 

 
Licensee, its Affiliates and Sublicensees, Net Sales of Company Products by Licensee and its Affiliates, and Sublicensing Revenues received, during such calendar quarter. 

 

	6.	 Development and Commercialization Activities. 

6.1        Commercial Development Plan and
Benchmarks.    Within [...***...] after the Effective Date, Licensee shall provide to TSRI an initial Commercial Development Plan, to be attached hereto as Exhibit E, under which Licensee
intends to bring the subject matter of the Licensed Patent Rights to the point of commercial use. This Commercial Development Plan is hereby incorporated by reference into this Agreement. Licensee shall also provide to TSRI within [...***...]
of the Effective Date a schedule of diligence benchmarks, to be attached hereto as Exhibit F (“Benchmarks”), including time periods in which such Benchmarks are to be
achieved, and such schedule of Benchmarks is hereby incorporated by reference into this Agreement. Licensee may provide TSRI with updated versions of the Commercial Development Plan from time to time as necessary to reflect results of
Licensee’s development efforts or other relevant developments (e.g., if the results of a study contemplated by the initial Commercial Development Plan suggest that the design of a subsequent study contemplated by the initial Commercial
Development Plan be changed, or that a different study be conducted in its place); provided, however, that any update to the Commercial Development Plan, in its then-current form, shall be consistent with, and cover activities directed to,
achievement of the Benchmarks within the time periods set forth in Exhibit F (as such Benchmarks may be amended in accordance with Section 6.2.3). 

6.2        Development Efforts and Progress Reports. 

6.2.1    Licensee shall use [...***...] and due diligence, itself and/or through one or more
Affiliates or Sublicensees, to develop, and to obtain regulatory approval to market, Products in the Field, as promptly as is reasonably and commercially feasible, and, subject to obtaining necessary regulatory approvals in the Field, to produce and
sell reasonable quantities of Products sufficient to meet market demand in the Field. Without limiting the generality of the foregoing, Licensee shall achieve the Benchmarks within the time periods set forth in Exhibit F.

 6.2.2    Licensee shall keep TSRI generally informed as to Licensee’s progress with respect to
its development of Products, including without limitation its regulatory filings and approvals, marketing, production, sale and its efforts to sublicense the Licensed Technology. Licensee shall provide to TSRI a written annual report on its progress
in the development and commercialization of Products in the Field by [...***...]. These progress reports shall include, but not be limited to: progress on research and development, status of applications for regulatory approvals, progress
towards achieving the Benchmarks and performance of the Commercial Development Plan (as in effect from time to time), manufacturing, sublicensing, marketing, importing, and sales during the preceding calendar year, as well as plans for the present
calendar year. TSRI also encourages these reports to include information on any of Licensee’s public service activities that relate to the Licensed Technology or Licensed Biological Materials. If reported progress differs from that previously
projected by Licensee, Licensee shall explain the reasons for such differences. The contents of Licensee’s progress reports to TSRI shall be deemed to be Licensee’s Confidential Information. Licensee

  
 ***Confidential
Treatment Requested 
  
 14 

 
agrees to provide any additional information reasonably required by TSRI to evaluate Licensee’s performance under this Agreement. Licensee shall provide reasonable prior written notice to
TSRI of any Licensee Scientific Advisory Board meeting at which Products are expected to be discussed, and at TSRI’s option, a representative of TSRI has the right to be present at such meeting (or the portion thereof relating to Products).

 6.2.3    Licensee may amend the Benchmarks only upon TSRI’s prior written consent. TSRI shall
not unreasonably withhold approval of any request of Licensee to amend the Benchmarks or to extend the time period for achievement thereof if Licensee reasonably demonstrates to TSRI that Licensee has used its [...***...] to achieve the
Benchmarks and the parties mutually agree upon appropriate conditions (which may, but need not, include extension payments to TSRI) or other provisions for such amendment. If Licensee does not achieve a Benchmark within the time provided in
Exhibit F (as may be amended or extended as provided above), TSRI has the right to terminate Licensee’s license rights hereunder upon 45 days’ written notice to Licensee. 

6.2.4    At any time after the third anniversary of the Effective Date, TSRI has the right to terminate
this Agreement or the license rights hereunder with respect to a particular Licensed Product or country, at TSRI’s option, upon 45 days’ prior written notice to Licensee if TSRI has a reasonable basis to believe, based on
Licensee’s reports and other available information, that Licensee is not complying with its diligence obligations under Section 6.2.1, unless, prior to the end of such 45-day notice period, Licensee
reasonably demonstrates to TSRI that Licensee is complying with its diligence obligations under Section 6.2.1. Achievement of the Benchmarks specified in Exhibit F before the dates set forth therein shall be evidence
of compliance by Licensee with its diligence obligations for such matters during the time periods specified in Exhibit F. 

6.2.5    Licensee shall report to TSRI the dates for achieving each Benchmark specified in
Exhibit F and each of the events described in Section 4.2 within [...***...] of such occurrences. 

6.3        Reports on Revenues and Payments. Licensee shall submit to TSRI, no
later than [...***...] after the end of each calendar quarter, a royalty report (the “Royalty Report”) setting forth for such quarter at least the following information on a country-by-country and Product-by-Product basis: 

(a)        the number of (i) Licensed Products sold by Licensee, and its
Affiliates and Sublicensees and (ii) Company Products sold by Licensee and its Affiliates; 

(b)        the gross amounts due or invoiced for such Products; 

(c)        a reasonably detailed listing of any deductions applicable to determine the
Net Sales of Products pursuant to Section 1.16, the calculation for Combination Products under Section 3.12, and any refunds or reimbursed amounts previously deducted which are deemed Net Sales pursuant to Section 1.16; 

(d)        the amount of Sublicensing Revenues received by Licensee; 

  
 ***Confidential
Treatment Requested 
  
 15 

 (e)        the amount of royalties
due under Section 3, or if no royalties are due to TSRI for any quarterly period, the statement that no royalties are due and an explanation why they are not due for that quarterly period; 

(f)        the amount of Sublicense Payments due under Section 4.1, or if no
Sublicense Payments are due to TSRI for any quarterly period, the statement that no Sublicense Payments are due and an explanation of why they are not due for that quarterly period; 

(g)        the amount of Non-Sublicensing
Transaction Revenues received by Licensee and its Affiliates; provided, however, that effective upon the Conversion Date, Licensee’s obligation to report Non-Sublicensing Transaction Revenues
hereunder shall terminate and be of no further force or effect; and 

(h)        cumulative expenditures (i.e., operating expenses) by Licensee from
inception to the end of the applicable calendar quarter; provided, however, that effective upon delivery of the Royalty Report for the quarter in which Licensee’s cumulative expenditures first exceed US$[...***...], Licensee’s
obligation to report cumulative expenditures hereunder shall terminate and be of no further force or effect. 
 Such Royalty Report shall be
certified as correct by an officer of Licensee. 
 6.4        Royalty
Payments. Licensee agrees to pay and shall pay to TSRI with each Royalty Report the amount of royalty and/or Sublicense Payments due with respect to such quarter. If multiple technologies are covered by the license granted hereunder and Products
are based on different technologies, Licensee shall specify which Licensed Patent Rights are utilized for each Licensed Product included in the Royalty Report. All payments due hereunder shall be deemed received when funds are credited to
TSRI’s bank account and shall be payable by check or wire transfer in United States Dollars. 

6.5        Foreign Sales. The remittance of royalties payable on sales outside
the United States shall be payable to TSRI in United States Dollar equivalents at the official rate of exchange of the currency of the country from which the royalties are payable, as quoted in the Wall Street Journal for the last business day of
the calendar quarter in which the royalties are payable. If the transfer of or the conversion into the United States Dollar equivalents of any such remittance in any such instance is not lawful or possible, the payment of such part of the royalties
as is necessary shall be made by the deposit thereof, in the currency of the country where the sale was made on which the royalty was based to the credit and account of TSRI or its nominee in any commercial bank or trust company of TSRI’s
choice located in that country, prompt written notice of which shall be given by Licensee to TSRI. 

6.6        Foreign Taxes. Any tax required to be withheld by Licensee under the
laws of any foreign country for any royalties or other amounts due hereunder or for the accounts of TSRI shall be promptly paid by Licensee for and on behalf of TSRI to the appropriate governmental authority, and Licensee shall furnish TSRI with
proof of payment of such tax together with official or other appropriate evidence issued by the applicable government authority. Any such tax actually paid on TSRI’s behalf shall be deducted from royalty payments due TSRI. 

  
 ***Confidential
Treatment Requested 
  
 16 

	7.	 Record Keeping. 

Licensee shall keep, and shall require its Affiliates, and, solely with respect to Licensed Products, Sublicensees, to keep,
accurate records (together with supporting documentation) of Products made, used or sold under this Agreement, appropriate to determine the amount of royalties, Sublicense Payments, Licensed Product Development Milestone Payments and other monies
due to TSRI hereunder, as well as records regarding the calculation of Net Sales of Combination Products and Licensee’s compliance with its financial obligations under this Agreement. Such records shall be retained for at least
[...***...] following the end of the reporting period to which such records relate. Such records shall be available, upon reasonable prior written notice to Licensee, during normal business hours for examination and copying by an independent
certified public accounting firm selected by TSRI and reasonably acceptable to Licensee, for the purpose of verifying Licensee’s reports and payments hereunder and its compliance with its financial obligations under this Agreement. In
conducting examinations pursuant to this Section, TSRI’s accountant shall have access to all records which such accountant reasonably believes to be relevant to the calculation of royalties under Section 3 and Sublicense Payments under
Section 4.1 and other financial obligations under this Agreement. Such accountant will agree in its engagement agreement with TSRI to keep such records of Licensee, its Affiliates and Sublicensees confidential. Such accountant may disclose to
TSRI its audit report and any information, including, without limitation, work papers, notes, interim reports and other work product of the accountant (but excluding any direct source documents of Licensee or any Sublicensee), that the accountant
reasonably believes to be relevant to the calculation of royalties under Section 3 and Sublicense Payments under Section 4.1 and other financial obligations under this Agreement, provided that all of such information that such accountant
discloses to TSRI shall be concurrently disclosed to Licensee. The contents of the accountant’s audit report (and any accompanying information permitted hereunder to be provided therewith) shall be deemed to be Licensee’s Confidential
Information. Such accountant will send a copy of the report to Licensee at the same time it is sent to TSRI. The report sent to both parties will include the methodology and calculations used to determine the results. 

Such examination by TSRI’s accountant shall be at TSRI’s expense, except that if such examination shows an
underreporting or underpayment in excess of [...***...]% for any 12-month period, then Licensee shall pay the cost of such examination (including without limitation TSRI’s attorney’s fees,
accountant’s fees and other costs) as well as any additional payments that would have been payable to TSRI had the Licensee reported correctly, plus interest on such amounts at the rate of [...***...]% per month. All payments due
hereunder shall be made within [...***...] of receipt of a written demand from TSRI. TSRI may exercise its audit rights under this Section 7 no more frequently than once in any calendar year, and no calendar year shall be subject to audit
under this Section 7 more than one time. 
  

	8.	 Patent Matters. 

8.1        Patent Prosecution and Maintenance.    From and
after the date of this Agreement, the provisions of this Section 8 shall control the prosecution of any patent application and maintenance of any patent included within Licensed Patent Rights. The parties shall select outside patent counsel
reasonably acceptable to both, to file, prosecute and maintain the Licensed Patent Rights, provided that TSRI shall be designated as the client, and [...***...] 

  
 ***Confidential
Treatment Requested 
  
 17 

 [...***...] as set forth below. Subject to the requirements, limitations and
conditions set forth in this Agreement, TSRI shall, using such mutually acceptable outside patent counsel, (a) direct and control the preparation, filing and prosecution of the United States and foreign patent applications within Licensed
Patent Rights (including without limitation any reissues, reexaminations, appeals to appropriate patent offices and/or courts, interferences and foreign oppositions); and (b) maintain the patents issuing therefrom. Both parties agree that TSRI
shall have the right, at its sole discretion, to utilize TSRI’s Office of Patent Counsel (“OPC”) in addition to independent counsel for the review and oversight of the filing, prosecution and maintenance of Licensed
Patent Rights described herein (“Supervisory Prosecution”), and [...***...]. Licensee shall have full rights of consultation with the independent patent attorney and with TSRI’s OPC on all matters relating to the
prosecution and maintenance of the Licensed Patent Rights. TSRI shall use reasonable efforts to implement all reasonable and timely requests made by Licensee with regard to the preparation, filing, prosecution and/or maintenance of the patent
applications and/or patents within Licensed Patent Rights; provided, however, that in the event of a disagreement between TSRI and Licensee on any such patent prosecution or maintenance matters, TSRI shall have final decision-making authority
over all such patent matters. 
 8.2        Information to Licensee. TSRI
shall keep Licensee timely informed with regard to the patent application and maintenance processes. TSRI shall deliver to Licensee copies of all patent applications, amendments, related correspondence, and other related matters in a timely manner.

 8.3        Patent Costs. Licensee acknowledges and agrees that the license
granted hereunder is in partial consideration for [...***...] as described herein. [...***...] referenced in Section 8.1 hereof. [...***...] associated with the work on the Licensed Patent Rights performed by TSRI’s OPC
and/or its independent counsel within [...***...] after Licensee receives an itemized invoice therefor. Failure of [...***...] as set forth in this Section 8.3 shall immediately relieve TSRI from its obligation to incur any further
patent costs and expenses. For the avoidance of doubt, if [...***...], TSRI shall have the right, at its sole discretion, to cease all patent prosecution and maintenance and allow the Licensed Patent Rights to go abandoned. Such action by TSRI
shall not constitute a breach of this Agreement. Licensee may elect, with a minimum of [...***...] prior written notice to TSRI, to discontinue payment for the filing, prosecution and/or maintenance of any patent application and/or patent
within Licensed Patent Rights. [...***...]. Any such patent application or patent so elected shall immediately be excluded from the definition of Licensed Patent Rights and from the scope of the licenses granted under this Agreement, and all
rights relating thereto shall revert to TSRI and may be freely licensed by TSRI. 

  
 ***Confidential
Treatment Requested 
  
 18 

8.4        Ownership.    The patent applications filed and
the patents obtained by TSRI pursuant to Section 8.1 hereof shall be owned solely by TSRI, assigned solely to TSRI and deemed a part of Licensed Patent Rights. For the avoidance of doubt, ownership of any inventions made in whole or in part by
Licensee in practicing the Licensed Technology, including patent applications and patents claiming such inventions, shall follow inventorship, which shall be determined in accordance with U.S. patent law. 

8.5        TSRI Right to Pursue Patent.    If at any time
during the term of this Agreement, Licensee’s rights with respect to Licensed Patent Rights are terminated, TSRI shall have the right to take whatever action TSRI deems appropriate to obtain or maintain the corresponding patent protection. If
TSRI pursues patents under this Section 8.5, Licensee agrees to cooperate fully, including by providing, at no charge to TSRI, all appropriate technical data and executing all necessary legal documents. 

8.6        Infringement Actions. 

8.6.1    Prosecution and Defense of Infringements.    In the event that either
TSRI or Licensee becomes aware of any infringement or threatened infringement by a Third Party of any Licensed Patent Rights, it shall notify the other party in writing to that effect. Licensee shall make good faith efforts to abate or terminate
such infringement. Licensee shall have the first right (but not the obligation) to bring and control any action or proceeding against a Third Party with respect to infringement (including patent invalidation and nullity actions) of any Licensed
Patent Right, [...***...] and by counsel of its own choice, and TSRI shall have the right, [...***...], to be represented in any such action by counsel of its own choice. If Licensee fails to bring any such action or proceeding within
(A) [...***...] following the notice of alleged infringement, or (B) [...***...] before the time limit, if any, set forth in the appropriate laws and regulations for the filing of such actions, whichever comes first, then TSRI
shall have the right to bring and control any such action, [...***...] and by counsel of its own choice, and Licensee shall have the right, [...***...], to be represented in any such action by counsel of its own choice. 

8.6.2    Allocation of Recovery.    Any damages or other recovery from an
infringement action undertaken by Licensee pursuant to Section 8.6.1 shall first be used to reimburse the parties for the costs and expenses incurred in such action, and any remaining amounts after such reimbursement shall be [...***...].
If Licensee fails to prosecute any such action or fails to prosecute such action to completion and TSRI instead prosecutes such action, then any damages or other recovery net of the parties’ costs and expenses incurred in such infringement
action shall be [...***...]. 
  

	9.	 Indemnity and Insurance. 

9.1        Indemnity.    Licensee hereby agrees to
indemnify, defend (by counsel reasonably acceptable to TSRI) and hold harmless TSRI and any parent, subsidiary or other affiliated entity and their respective trustees, directors, officers, employees, scientists, students, agents,

  
 ***Confidential
Treatment Requested 
  
 19 

 
successors, assigns and other representatives (collectively, the “Indemnitees”) from and against all damages, claims, liabilities, losses and other expenses, including
without limitation reasonable attorney’s fees, expert witness fees and costs, as a result of any Third Party claim, incurred by or asserted against Indemnitees, whether or not a lawsuit or other proceeding is filed
(“Claim”), that arise out of or relate to (a) Licensee’s, its Affiliate’s or any Sublicensee’s use of any of the Licensed Technology, (b) alleged defects or other problems with any of the Products
manufactured, sold or distributed by or on behalf of Licensee, its Affiliate or any Sublicensee, including without limitation any personal injuries, death or property damages related thereto, (c) the research, development, manufacture, use,
marketing, advertising, distribution, sale or importation of any Product by or on behalf of Licensee, its Affiliate or any Sublicensee, (d) any allegations that the Products developed, manufactured, sold or distributed by or on behalf of
Licensee, its Affiliate or any Sublicensee and/or any trademarks, service marks, logos, symbols, slogans or other materials used in connection with or to market Products violate or infringe upon the trademarks, service marks, trade dress, trade
names, copyrights, patents, works of authorship, inventorship rights, trade secrets, database rights, rights under unfair competition laws, rights of publicity, privacy or defamation, or any other intellectual or industrial property rights of any
Third Party, (e) Licensee’s, its Affiliate’s or any Sublicensee’s failure to comply with any applicable laws, rules or regulations in connection with the exercise of its rights or the performance of its obligations under this
Agreement, (f) the negligent or willful acts or omissions of Licensee, its Affiliate or any Sublicensee, and/or (g) the labeling, packaging or patent marking of any Product or containers thereof by or on behalf of Licensee, its Affiliate
or a Sublicensee. In each case, Licensee’s liability for damages under its indemnity shall be reduced or apportioned to the extent such Claim arising out of or relating to the actions referenced in sub-clauses (a) - (g) is proximately
caused by the gross negligence or willful misconduct of any Indemnitee or by TSRI’s breach of its representations and warranties under Section 10.1. Licensee shall not enter into any settlement, stipulated judgment or other arrangement
with respect to such Claims that (i) imposes any obligation on Indemnitees, (ii) does not unconditionally release Indemnitees from all liability, or (iii) would have an adverse effect on TSRI’s reputation or business, without
TSRI’s prior written consent. In the event an Indemnitee seeks indemnification with respect to a Claim under this Section 9, it shall inform Licensee of such Claim as soon as reasonably practicable after it receives notice of such Claim,
shall permit Licensee to assume direction and control of the defense of the Claim (including the right to settle the Claim solely for monetary consideration, subject to the limitations of the preceding sentence) using counsel selected by Licensee
and reasonably acceptable to TSRI, and shall cooperate as reasonably requested (at the expense of Licensee) in the defense of the Claim. Notwithstanding the above, Indemnitees, [...***...], shall have the right to retain separate independent
counsel to assist in defending any such Claims. If Licensee assumes direction and control of defense of the Claim, no Indemnitee shall agree to any settlement of such Claim without the prior written consent of Licensee. In the event Licensee fails
to assume control of such defense within [...***...] after receiving written notice of the Claim from an Indemnitee and/or pay such Indemnitee’s expenses as provided above, such Indemnitee shall have the right, but not the obligation, to
defend itself, and in that case, Licensee shall reimburse such Indemnitee for all of its reasonable and documented attorney’s fees, costs and damages incurred in settling or defending such Claims within [...***...] after receipt of any
invoice therefor from such Indemnitee. This indemnity shall be a direct payment obligation and not merely a reimbursement obligation of Licensee to Indemnitees. 

  
 ***Confidential
Treatment Requested 
  
 20 

 9.2        Insurance.
Licensee shall name TSRI and Indemnitees as “additional insureds” on any commercial general liability and product liability insurance policies maintained by Licensee, its Affiliates and Sublicensees applicable to the Products. 

9.2.1    Beginning at the time any Product is being commercially distributed or sold (other than for the
purpose of obtaining regulatory approvals) by Licensee, its Affiliate or a Sublicensee, Licensee shall, at its sole cost and expense, procure and maintain commercial general liability insurance in amounts not less than $[...***...] per
incident and $[...***...] annual aggregate and naming the Indemnitees as additional insureds. Prior to initiation of the first clinical trials and continuing throughout the clinical trials involving any Product, Licensee shall, at its sole
cost and expense, procure and maintain commercial general liability insurance in amounts not less than $[...***...] per occurrence and $[...***...] annual aggregate, naming the Indemnitees as additional insureds. Such commercial general
liability insurance shall provide coverage for (i) product liability or completed operations/clinical trial coverage, as applicable; and (ii) broad form property damage, advertising injury, premises operations, personal injury and
contractual liability coverage for Licensee’s indemnification obligations under this Agreement. If Licensee elects to self-insure all or part of the limits described above (including deductibles or retentions which are in excess of
$[...***...] annual aggregate) such self-insurance program must be acceptable to TSRI in its sole discretion. The insurance coverage amounts specified herein or the maintenance of such insurance policies shall not in any way limit
Licensee’s indemnity or other liability under this Agreement. 
 9.2.2    In addition, Licensee, on
behalf of itself and its insurance carriers, waives any and all claims and rights of recovery against TSRI and the Indemnitees, including without limitation all rights of subrogation, with respect to either party’s performance under this
Agreement or for any loss of or damage to Licensee or its property or the property of others under its control. Licensee’s commercial general liability insurance policy shall also include a waiver of subrogation consistent with this paragraph
in favor of TSRI and the Indemnitees. Licensee shall be responsible for obtaining such waiver of subrogation from its insurance carriers. Licensee’s insurance policies shall be primary and not contributory to any insurance carried by its
Sublicensees or by TSRI. Upon TSRI’s request, Licensee shall deliver to TSRI copies of insurance certificates or endorsements that comply with the requirements of this Section 9. 

9.2.3    Licensee shall provide TSRI with written notice at least [...***...] prior to the
cancellation, non-renewal or material adverse change in such insurance, provided that if Licensee itself becomes aware of any such cancellation, non-renewal or material
adverse change less than [...***...] before such cancellation, non-renewal or material adverse change becomes effective, through no fault of Licensee, then Licensee shall provide TSRI with written notice
as promptly as practicable after Licensee becomes aware of same. If Licensee does not obtain replacement insurance providing comparable coverage within such [...***...] period (or prior to the cancellation,
non-renewal or material change in the existing policy, TSRI shall have the right to immediately terminate this Agreement by providing written notice to Licensee and without any additional cure periods. 

9.2.4    Licensee shall maintain such commercial general liability insurance beyond the expiration or
termination of this Agreement during [...***...] 

  
 ***Confidential
Treatment Requested 
  
 21 

 [...***...]. 

 

	10.	 Limited Warranty. 

10.1    Limited Warranty.    TSRI hereby represents and warrants that, to the
best of its actual knowledge and only as of the Effective Date, that it has full corporate authorization and power to enter into this Agreement and that the execution and delivery of this Agreement do not constitute a breach of any agreement to
which TSRI is a party. Notwithstanding anything stated herein to the contrary, TSRI does not make any express or implied warranty or representation regarding the non-infringement of Third Party rights or of
title to the Licensed Biological Materials. 
 10.2    Disclaimer.    EXCEPT
AS SET FORTH IN SECTION 10.1, NEITHER PARTY MAKES ANY WARRANTIES OR REPRESENTATIONS CONCERNING ANY LICENSED TECHNOLOGY, PRODUCTS OR ANY OTHER MATTER WHATSOEVER, INCLUDING WITHOUT LIMITATION ANY EXPRESS OR IMPLIED OR STATUTORY WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT OF THIRD PARTY RIGHTS, TITLE, ACCURACY, OR ARISING OUT OF COURSE OF CONDUCT OR TRADE CUSTOM OR USAGE, AND EACH PARTY DISCLAIMS ALL SUCH
EXPRESS, IMPLIED OR STATUTORY WARRANTIES. NEITHER PARTY MAKES ANY WARRANTY OR REPRESENTATION AS TO THE VALIDITY, SCOPE OR ENFORCEABILITY OF ANY LICENSED TECHNOLOGY OR THAT ANY LICENSED TECHNOLOGY OR PRODUCT WILL NOT INFRINGE ANY THIRD PARTY RIGHTS,
OR THAT NO THIRD PARTY IS IN ANY WAY INFRINGING UPON OR MAY INFRINGE UPON ANY LICENSED TECHNOLOGY COVERED BY THIS AGREEMENT. FURTHER, TSRI HAS MADE NO INVESTIGATION AND MAKES NO REPRESENTATION OR WARRANTY THAT THE LICENSED TECHNOLOGY IS SUITABLE FOR
LICENSEE’S PURPOSES. LICENSEE MAKES NO REPRESENTATION OR WARRANTY REGARDING THE SUCCESS OF EFFORTS TO DEVELOP AND COMMERCIALIZE PRODUCTS. 

10.3    Limitation of Liability.    IN NO EVENT SHALL EITHER PARTY BE LIABLE
FOR ANY INDIRECT, SPECIAL, INCIDENTAL, EXEMPLARY OR CONSEQUENTIAL DAMAGES (INCLUDING WITHOUT LIMITATION DAMAGES FOR LOST PROFITS OR EXPECTED SAVINGS ARISING OUT OF OR IN CONNECTION WITH THIS AGREEMENT OR ITS SUBJECT MATTER; provided, however,
that this Section 10.3 shall not be construed to limit Licensee’s indemnification obligations under Section 9.1. TSRI’S AGGREGATE LIABILITY, IF ANY, FOR ALL DAMAGES OF ANY KIND RELATING TO THIS AGREEMENT OR ITS SUBJECT MATTER
SHALL NOT EXCEED THE AMOUNT PAID BY LICENSEE TO TSRI UNDER THIS AGREEMENT. THE FOREGOING EXCLUSIONS AND LIMITATIONS SHALL APPLY TO ALL CLAIMS AND ACTIONS OF ANY KIND AND ON ANY THEORY OF LIABILITY, WHETHER BASED ON CONTRACT, TORT (INCLUDING, BUT NOT
LIMITED TO NEGLIGENCE OR STRICT LIABILITY), OR ANY OTHER GROUNDS, AND REGARDLESS OF WHETHER TSRI HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, AND NOTWITHSTANDING 

  
 ***Confidential
Treatment Requested 
  
 22 

 
ANY FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY. THE PARTIES FURTHER AGREE THAT EACH WARRANTY DISCLAIMER, EXCLUSION OF DAMAGES OR OTHER LIMITATION OF LIABILITY HEREIN IS INTENDED TO BE
SEVERABLE AND INDEPENDENT OF THE OTHER PROVISIONS SINCE THEY EACH REPRESENT SEPARATE ELEMENTS OF RISK ALLOCATION BETWEEN THE PARTIES. 
  

	11.	 Confidentiality and Publication. 

11.1    Treatment of Confidential Information. The parties agree that [...***...], a party
receiving Confidential Information of the other party will (a) maintain in confidence such Confidential Information to the same extent such party maintains its own proprietary information; (b) not disclose such Confidential Information to
any Third Party without prior written consent of the other party; and (c) not use such Confidential Information for any purpose except those permitted by this Agreement. Notwithstanding the foregoing, if a party is required by law, regulation
or court order to disclose Confidential Information of the other party, the party required to make such disclosure shall (i) limit the same to the minimum required to comply with the law or court order, (ii) use reasonable efforts to
attempt to seek confidential treatment for that disclosure, and (iii) prior to making such disclosure that party shall send a copy of the order or notice to the other party, not later than [...***...] (or such shorter period of time as
may be reasonably practicable under the circumstances) before the disclosure and reasonably cooperate with the other party in order to allow that other party to comment and/or to obtain a protective or other order, including extensions of time and
the like, with respect to such disclosure. In addition, a party may disclose Confidential Information of the other party to employees or consultants, to Affiliates, Sublicensees and potential Sublicensees (in the case of Licensee), or to other Third
Parties in connection with due diligence or similar investigations by such Third Parties or potential Third Party investors in confidential financing documents, provided, in each case, that any such employee, consultant, Affiliate, Sublicensee,
potential Sublicensee or other Third Party agrees in writing to be bound by terms of confidentiality and non-use at least as stringent as those set forth in this Section 11, but with no further right to
disclose or otherwise distribute the other party’s Confidential Information. Notwithstanding anything to the contrary in this Agreement, TSRI has the right to disclose Licensee’s Confidential Information to an organization to whom TSRI
will or intends to assign or transfer this Agreement or the payment obligations due to TSRI under this Agreement for monetization purposes, provided that such organization agrees in writing to be bound by terms of confidentiality with respect to
Licensee’s Confidential Information at least as protective as those set forth in this Section 11.1. 

11.2    Publications. Licensee agrees that TSRI shall have a right to publish in accordance with its
general policies, and that, subject to TSRI’s compliance with Section 11.1 as it applies to Confidential Information of Licensee, this Agreement shall not restrict, in any fashion, TSRI’s right to publish. 

11.3    Publicity. Except as otherwise provided herein or required by law, no party shall originate
or distribute any publication, news release or other public announcement, written or oral, whether in the public press, stockholders’ reports, or otherwise, relating to this Agreement or to any sublicense hereunder, or to the performance
hereunder or under any such sublicense agreements, without the prior written approval of the other party, which approval shall not be 

  
 ***Confidential
Treatment Requested 
  
 23 

 
unreasonably withheld. Scientific publications published in accordance with Section 11.2 of this Agreement shall not be construed as publicity governed by this Section 11.3. 

 

	12.	 Term and Termination. 

12.1    Term. Unless terminated sooner in accordance with the terms set forth herein, this
Agreement, and the license granted hereunder, shall expire upon the expiration of all of Licensee’s royalty payment obligations hereunder as provided in Section 3.10 hereof. 

12.2    Termination Upon Mutual Agreement. This Agreement may be terminated by mutual written
consent of both parties. 
 12.3    Termination by TSRI. TSRI has the right to immediately
terminate this Agreement as follows (unless a further cure period is provided below): 

(a)        If Licensee does not make a payment due hereunder and fails to cure such non-payment (including the payment of interest in accordance with Section 14.2) within 15 days after the date of notice in writing of such non-payment by TSRI; 

(b)        If Licensee defaults in its indemnification and/or insurance obligations
under Section 9; 
 (c)        As provided in Section 6.2; 

(d)        If Licensee is adjudicated insolvent, makes an assignment for the benefit
of creditors, has a petition in bankruptcy filed for or against it, has a receiver appointed over any of Licensee’s assets, or in the event of the filing of any proceedings against Licensee under any bankruptcy or insolvency law. Such
termination shall be effective immediately upon TSRI giving written notice to Licensee; 

(e)        If an audit by TSRI’s accountant pursuant to Section 7 shows an
underreporting or underpayment by Licensee of 15% or more for any calendar year, and a subsequent audit conducted within three (3) years after the first audit shows a similar underreporting or underpayment by Licensee of 15% or more for any
subsequent calendar year; 
 (f)        If Licensee is convicted of a felony
relating to the development, manufacture, use, marketing, distribution or sale of Products or Derived Products; 

(g)        In the event Licensee, its Affiliate or a Sublicensee directly or
indirectly institutes or makes any Challenges; provided, however, that if a Sublicensee directly or indirectly institutes or makes any Challenge: (i) TSRI shall have the right to terminate only that portion of the license granted to
Licensee under Section 2.1 that relates to the Licensed Product to which such Sublicensee has been granted a sublicense; and (ii) except as expressly provided in the preceding clause (i), this Agreement, including, without limitation,
Licensee’s license under Section 2.1 and all other sublicenses granted by Licensee thereunder, shall otherwise remain in full force and effect; or 

  
 24 

 (h)        Except as provided in
subparagraphs (a) - (g) above, if Licensee defaults in the performance of any obligations under this Agreement and the default has not been remedied within 45 days after the date of notice in writing of such default by TSRI. 

12.4    Termination by Licensee. Licensee may terminate this Agreement by giving 90 days
advance written notice of termination to TSRI. 
 12.5    Rights Upon Expiration. Upon expiration
(but not earlier termination) of this Agreement, the licenses granted to Licensee hereunder shall survive as non-exclusive licenses on a fully-paid, royalty-free, irrevocable, perpetual basis. Except as
provided in the preceding sentence, neither party shall have any further rights or obligations upon the expiration of this Agreement upon its regularly scheduled expiration date, other than the obligation of Licensee to make any and all reports and
payments due under Sections 3, 4, 8 and 12.8 with respect to events that occurred prior to such expiration in accordance with Sections 5, 6.3, 6.4, 6.5, 6.6 and 8.3, all of which Sections referenced in this sentence shall survive such
expiration for such purposes. Notwithstanding the above, Sections 1, 2.3, 2.4, 2.5, 7, 8.4, 9, 10.2, 10.3, 11, 12.5, 13 and 14 shall also survive the expiration of this Agreement. 

12.6    Rights Upon Termination. 

12.6.1    Notwithstanding any other provision of this Agreement, upon any termination of this Agreement
prior to the regularly scheduled expiration date of this Agreement, the licenses granted hereunder shall terminate and revert to TSRI. Except as otherwise provided in Section 12.7 of this Agreement with respect to
work-in-progress, upon such termination, Licensee shall have no further right to develop, manufacture, market or sell any Licensed Product, or to otherwise use any
Licensed Patent Rights. Upon any such termination, Licensee shall promptly return all materials, samples, documents, information, and other materials which embody or disclose Licensed Patent Rights; provided, however, that Licensee shall not
be obligated to provide TSRI with proprietary information which Licensee can show that it independently developed. Any such termination shall not relieve either party from any obligations accrued to the date of such termination, including without
limitation the obligation of Licensee to make any and all reports and payments due under Sections 3, 4, 8 and 12.8 with respect to events that occurred prior to such termination or as provided in Section 12.7, and in each case in
accordance with Sections 5, 6.3, 6.4, 6.5, 6.6 and 8.3, and all of such Sections referenced in this sentence shall survive such termination for such purposes. In addition, Sections 1, 2.3, 2.4, 2.5, 7, 8.4, 9, 10.2, 10.3, 11, 12.6, 13 and
14 shall also survive the termination of this Agreement. 
 12.6.2    Any sublicense may, at the
election of the applicable Sublicensee, survive termination of this Agreement for the benefit of TSRI, in accordance with the provisions of this Section 12.6.2. Upon termination of this Agreement, and at the written request of a Sublicensee,
TSRI will grant to each Sublicensee, not then in default, an option to obtain directly from TSRI a license agreement on substantially the same terms and conditions set forth in the applicable sublicense and as set forth below. On or before the
expiration of 60 days from the date of termination of this Agreement pursuant to Section 12.6.1, each Sublicensee may provide TSRI with a written notice of intent to exercise the option set forth in this Section 12.6.2. In the event a
Sublicensee elects to exercise this option and provides its written notice thereof within the 

  
 25 

 
60-day period, as a condition precedent to TSRI’s obligation to grant the direct license to that Sublicensee, such Sublicensee must pay to TSRI all past due royalties, non-royalty revenue,
patent costs and all other monies owed by Licensee to TSRI under this Agreement with respect to the Product(s) to which such Sublicensee has a sublicense. Upon TSRI’s receipt of all such outstanding monies, TSRI shall enter into a license
agreement directly with each such Sublicensee (the “New License Agreement”). Each New License Agreement shall be subject to the same non-financial terms and conditions as those in this Agreement; provided, however,
that each New License Agreement shall contain substantially the same terms and conditions regarding sublicense scope, sublicense territory, duration of sublicense grant, and diligence obligations of the Sublicensee as the sublicense agreement
between such Sublicensee and Licensee. Notwithstanding the above, TSRI’s obligation to enter into a New License Agreement is expressly conditioned upon each of the following: (i) Sublicensee shall agree in the New License Agreement to
terms providing that in no event shall TSRI be liable to Sublicensee for any actual or alleged breach of such sublicense agreement by Licensee; (ii) TSRI shall not have any obligations to such Sublicensee other than TSRI’s obligations to
Licensee as set forth herein; (iii) each New License Agreement shall be subordinate and comply in all respects to the applicable provisions of this Agreement; (iv) the financial terms of each New License Agreement, including without
limitation, the running royalty rate, shall be consistent with the terms of the sublicense agreement with Licensee; and (v) in no event shall TSRI be obliged to accept provisions in the New License Agreement (a) unless such provisions
correspond to rights granted by Licensee to Sublicensee in conformance with this Agreement, and such provisions are not in conflict with the rights, duties and obligations accruing to Licensee under this Agreement; or (b) where such provisions
are inconsistent with the legal obligations under any other sublicense agreement granted by Licensee, or by applicable federal, state or local statute or regulation. Licensee must include or specifically reference this Section 12.6.2 in each of
its sublicense agreements in order for such Sublicensee to have the option described above. 

12.7    
Work-in-Progress. Upon any such early termination of the license granted hereunder in accordance with this Agreement, Licensee shall be entitled to
finish any work-in-progress and to sell any completed inventory of a Licensed Product covered by such license which remain on hand as of the date of the termination, so
long as Licensee sells such inventory in the normal course of business and at regular selling prices and pays to TSRI the royalties applicable to said subsequent sales in accordance with the terms and conditions as set forth in this Agreement,
provided that no such sales shall be permitted following the date that is six (6) months after the date of termination. 

12.8    Final Royalty Report. Upon termination or expiration of this Agreement, Licensee shall
submit a final report to TSRI, and any payments due TSRI and unreimbursed patent fees and expenses incurred prior to such expiration or termination shall become immediately payable to TSRI. 

 

	13.	 Assignment; Successors. 

13.1    Assignment.    Any and all assignments of this Agreement or any rights
granted hereunder by Licensee without TSRI’s prior written consent are void, except that Licensee may assign this Agreement and its rights and obligations hereunder without TSRI’s consent: (a) to an Affiliate; or (b) in
connection with the transfer or sale of all or substantially all of Licensee’s 

  
 26 

 
business to a Third Party, whether by merger, sale of stock, sale of assets or otherwise; provided that the successor or assignee of Licensee’s interest shall expressly assume in writing the
performance of all the terms and conditions of this Agreement to be performed by Licensee and such written assumption shall be delivered to TSRI concurrently with the consummation of such transfer or assignment. 

13.2    Binding Upon Successors and Assigns.    Subject to the limitations on
assignment herein, this Agreement shall be binding upon and inure to the benefit of any successors in interest and assigns of TSRI and Licensee. Any such successor or assignee of Licensee’s interest shall expressly assume in writing the
performance of all the terms and conditions of this Agreement to be performed by Licensee and such written assumption shall be delivered to TSRI as a condition to TSRI’s agreement to consent to any such assignment. 

 

	14.	 General Provisions. 

14.1    Independent Contractors.    The relationship between TSRI and Licensee
is that of independent contractors. TSRI and Licensee are not joint venturers, partners, principal and agent, master and servant, employer or employee, and have no other relationship other than independent contracting parties. TSRI and Licensee
shall have no power to bind or obligate each other in any manner, other than as is expressly set forth in this Agreement. 

14.2    Late Payments.    Late payments of any and all payments due hereunder
shall be subject to a charge of [...***...]% per month, or US$[...***...], whichever is greater. 

14.3    Governmental Approvals and Marketing of Licensed Products.    Licensee
shall be responsible for obtaining all necessary governmental approvals for the development, production, distribution, performance, sale and use of any Product, at Licensee’s expense, including, without limitation, any safety studies. Licensee
shall have sole responsibility for any warning labels, packaging and instructions as to the use of Products and for the quality control for any Products. 

14.4    Patent Marking.    To the extent required by applicable law, Licensee
shall mark all Licensed Products or their containers in accordance with the applicable patent marking laws. 

14.5    No Use of Name.    The use of the name “The Scripps Research
Institute”, “Scripps”, “TSRI” or any variation thereof in connection with the marketing, advertising, distribution or sale of Products is expressly prohibited. 

14.6    U.S. Manufacture.    To the extent required, Licensee agrees to abide by
the Preference for United States Industry as set forth in 37 CFR 401.14 (I). 
 14.7    Foreign
Registration.    Licensee, at its expense, shall register this Agreement with any foreign governmental agency which requires such registration. In addition, Licensee shall ensure that all foreign laws affecting this Agreement
or the sale of Products are fully satisfied. 
 14.8    Use of Biological
Materials.    Licensee agrees that its use of any Licensed Biological Materials shall comply with all applicable laws, rules, statutes, regulations, and guidelines. Licensee agrees not to use the Licensed Biological Materials
for research involving human subjects or clinical trials in the United States without complying with 21 CFR 50 and 45 

  
 ***Confidential
Treatment Requested 
  
 27 

 
CFR 46. Licensee agrees not to use the Licensed Biological Materials for research involving human subjects or clinical trials outside of the United States without complying with the applicable
regulations of the appropriate national control authorities. 
 14.9    Arbitration. Any
controversy or claim arising out of or relating to this Agreement, or the breach thereof, shall be referred to the Chief Executive Officer of Licensee and a designated official of TSRI with authority to resolve such dispute, for resolution. Such
individuals shall meet to discuss such controversy or claim within [...***...] after the request of either party and shall work in good faith to resolve such controversy or claim within [...***...] thereafter. In the event the two
individuals referred to in the preceding sentence are unable to resolve such dispute prior to the end of such [...***...] period, then, upon the written request of either party to the other party, the dispute shall be settled by binding
confidential arbitration in accordance with the Commercial Arbitration Rules of the American Arbitration Association (“AAA”), and the procedures set forth below; provided, however, that any
Challenge and any controversy or claim relating solely to the construction of the claims of the Licensed Patent Rights or the infringement of the Licensed Patent Rights shall be determined solely by a court or other government body of competent
jurisdiction. In the event of any inconsistency between the Rules of AAA and the procedures set forth below, the procedures set forth below shall control. Judgment upon the award rendered by the arbitrators may be enforced in any court having
jurisdiction thereof. 
 14.9.1    Location. The location of the arbitration shall be in the
County of San Diego. TSRI and Licensee hereby irrevocably submit to the exclusive jurisdiction and venue of the American Arbitration Association arbitration panel selected by the parties and located in San Diego County, California for any claim or
controversy that is subject to arbitration pursuant to Section 14.9, and waive any right to contest or otherwise object to such exclusive jurisdiction or venue. TSRI and Licensee further irrevocably submit to the exclusive jurisdiction and
venue of the Federal courts located in San Diego County, California for any Challenges (other than Challenges which are subject to the exclusive jurisdiction of the U.S. Patent and Trademark Office and/Board of Patent Appeals and Interferences) with
respect to any U.S. Licensed Patent Rights and any controversy or claim relating solely to the construction of the claims of any U.S. Licensed Patent Rights or the infringement of any U.S. Licensed Patent Rights, and waive any right to contest or
otherwise object to such exclusive jurisdiction or venue. 
 14.9.2    Selection of Arbitrators.
The arbitration shall be conducted by a panel of three neutral arbitrators who are independent and disinterested with respect to the parties, this Agreement, and the outcome of the arbitration. Each party shall appoint one neutral arbitrator, and
these two arbitrators so selected by the parties shall then select the third arbitrator, and all arbitrators must have at least 10 years’ experience in mediating or arbitrating cases regarding the same or substantially similar subject
matter as the dispute between Licensee and TSRI. If one party has given written notice to the other party as to the identity of the arbitrator appointed by the party, and the party thereafter makes a written demand on the other party to appoint its
designated arbitrator within the next [...***...], and the other party fails to appoint its designated arbitrator within ten days after receiving said written demand, then the arbitrator who has already been designated shall appoint the other
two arbitrators. 

  
 ***Confidential
Treatment Requested 
  
 28 

 14.9.3    Discovery. The arbitrators shall
decide any disputes and shall control the process concerning these pre-hearing discovery matters. Pursuant to the Rules of AAA, the parties may subpoena witnesses and documents for presentation at the hearing.

 14.9.4    Case Management. Prompt resolution of any dispute is important to both parties; and
the parties agree that the arbitration of any dispute shall be conducted expeditiously. The arbitrators are instructed and directed to assume case management initiative and control over the arbitration process (including scheduling of events, pre-hearing discovery and activities, and the conduct of the hearing), in order to complete the arbitration as expeditiously as is reasonably practical for obtaining a just resolution of the dispute. 

14.9.5    Remedies. The arbitrators may grant any legal or equitable remedy or relief that the
arbitrators deem just and equitable, to the same extent that remedies or relief could be granted by a state or federal court, subject to the limitations of liability set forth in Section 10.3. The decision of any two of the three arbitrators
appointed shall be binding upon the parties. Notwithstanding anything to the contrary in this Agreement, prior to or while an arbitration proceeding is pending, either party has the right to seek and obtain injunctive and other equitable relief from
a court of competent jurisdiction to enforce that party’s rights hereunder. 

14.9.6    Expenses. The expenses of the arbitration, including the arbitrators’ fees, expert
witness fees, and attorney’s fees, may be awarded to the prevailing party, in the discretion of the arbitrators, or may be apportioned between the parties in any manner deemed appropriate by the arbitrators. Unless and until the arbitrators
decide that one party is to pay for all (or a share) of such expenses, both parties shall share equally in the payment of the arbitrators’ fees as and when billed by the arbitrators. 

14.9.7    Confidentiality. Except as set forth below, and as necessary to obtain or enforce a
judgment upon any arbitration award, the parties shall keep confidential the fact of the arbitration, the dispute being arbitrated, and the decision of the arbitrators. Notwithstanding the foregoing, the parties may disclose information about the
arbitration to persons who have a need to know, such as directors, trustees, management employees, witnesses, experts, investors, attorneys, lenders, insurers, and others who may be directly affected. Additionally, if a party has stock which is
publicly traded, the party may make such disclosures as are required by applicable securities laws or by the rules of any stock exchange upon which such party’s securities are traded or listed, but will use commercially reasonable efforts to
seek confidential treatment for such disclosure. 
 14.10    Entire Agreement; Modification. This
Agreement and all of the attached Exhibits (which are incorporated herein), together with the RFOA, that certain board observation rights letter between the parties dated as of the Effective Date and the Stock Issuance Agreement between the parties
with respect to the Initial Issuance, set forth the entire agreement and understanding between the parties as to the subject matter hereof and thereof, and supersede all prior or contemporaneous agreements or understandings, whether oral or written,
with respect to such subject matter. There shall be no amendments or modifications to this Agreement, except by a written document which is signed by both parties. 

  
 29 

 14.11    California
Law.    This Agreement shall be construed and enforced in accordance with the laws of the State of California without regard to its conflicts or choice of laws rules. 

14.12    Headings.    The headings for each article and section in this
Agreement have been inserted for convenience of reference only and are not intended to limit or expand on the meaning of the language contained in the particular article or section. 

14.13    Severability.    If any provision of this Agreement is judicially
determined to be invalid, void or unenforceable, the remaining provisions shall remain in full force and effect, and the stricken provision shall be revised in a manner that best reflects the original intent of the parties. 

14.14    No Waiver.    The failure of a party to enforce any of its rights
hereunder or at law or in equity shall not be deemed a waiver or a continuing waiver of any of its rights or remedies against the other party, unless such waiver is in writing and signed by the waiving party. 

14.15    Name.    Whenever there has been an assignment or a sublicense by
Licensee as permitted by this Agreement, the term “Licensee” as used in this Agreement shall also include and refer to, if appropriate, such assignee or Sublicensee. 

14.16    Attorneys’ Fees.    In the event of a dispute
between the parties or in the event of any default hereunder, [...***...]. 
 Notwithstanding anything to the contrary
herein, the parties agree that this Section 14.16 shall not apply and attorneys’ fees and costs shall not be awarded to either party with respect to any Challenge or any action where Licensee alleges that it is not required to comply with
or perform some or all of the provisions of this Agreement based upon a good faith claim that any of the Licensed Patent Rights are invalid or unenforceable. TSRI and Licensee each represent that it has been represented by its own counsel in the
negotiation and execution of this Agreement. Each party further represents it has relied solely on the advice and representation of its respective counsel in agreeing to this Section 14.16 and all of the other provisions of this Agreement. 

14.17    Notices. Any notices required by this Agreement shall be in writing, shall specifically
refer to this Agreement and shall be sent by registered or certified airmail, postage prepaid, or by facsimile, charges prepaid, or by overnight courier, postage prepaid and shall be forwarded to the respective addresses set forth below unless
subsequently changed by written notice to the other party: 
  

	 For TSRI: 
	 The Scripps Research Institute 

10550 North Torrey Pines Road, TPC-9 

La Jolla, California 92037 

Attention: Vice President, Business Development 

Fax No.: (858) 784-9910 

  
 ***Confidential
Treatment Requested 
  
 30 

	 with a copy to: 
	 The Scripps Research Institute 

10550 North Torrey Pines Road, TPC-8 

La Jolla, California 92037 

Attention: Chief Business Counsel 

Fax No.: (858) 784-9399 

 

	 For Licensee: 
	 Synthorx, Inc. 

11099 North Torrey Pines Road, Suite 290 

La Jolla, CA 92037 

Attention: President and Chief Executive Officer 

Fax No.: (858) 200-0821 

Notices shall be deemed delivered upon the earlier of (a) when received; (b) three (3) days after it was sent by registered or
certified mail, return receipt requested; (c) the date notice is sent via facsimile, provided the receipt is verified and a hard copy is sent by one of the other manners set forth herein; or (d) the day immediately following delivery to an
overnight courier guaranteeing next-day delivery (except Sunday and holidays). 

14.18    Compliance with U.S. Laws. Nothing contained in this Agreement shall require or permit
TSRI or Licensee to do any act inconsistent with the requirements of any United States law, regulation or executive order as the same may be in effect from time to time. 

14.19    Counterparts.    This Agreement may be executed in several
counterparts that together shall constitute originals and one and the same instrument. 

  
 31 

 IN WITNESS WHEREOF, the
parties have executed this Agreement by their duly authorized representatives as of the Effective Date. 
  

									
	TSRI:	 	Licensee:	  	    
			
	THE SCRIPPS RESEARCH INSTITUTE	 	 SYNTHORX, INC.
	  	
			
	By:   /s/ Scott Forrest                            	 	By:   /s/ Court Turner                        	  	
			
	Title: VP, Business Development        	 	Title: President and CEO                  	  	

  
 32 

 EXHIBIT A 

LICENSED BIOLOGICAL MATERIALS 

[...***...] 
  

  
 ***Confidential
Treatment Requested 

 EXHIBIT B 

LICENSED KNOW-HOW 

[...***...] 

  
 ***Confidential
Treatment Requested 

 EXHIBIT C 

LICENSED PATENT RIGHTS 
 [...***...]

  
 ***Confidential
Treatment Requested 

 EXHIBT D 

FORM OF STOCK ISSUANCE AGREEMENT 

Synthorx, Inc. 
 STOCK
ISSUANCE AGREEMENT 
 THIS STOCK ISSUANCE AGREEMENT (this
“Agreement”) is entered into as ofJuly 31st, 2014 (the “Execution Date”), by and between SYNTHORX, INC., a Delaware corporation (the
“Company”), and THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation
(“TSRI”), and is intended by the parties to satisfy certain of the Company’s obligations to TSRI under Section 3.2 of the License Agreement (as defined below) between the Company and TSRI. Capitalized
terms used but not defined in this Agreement shall have the meaning ascribed to such terms in the License Agreement. 
 RECITALS 

WHEREAS, TSRI and the Company have entered into that certain License Agreement, dated July 31st, 2014 (the “License Agreement”), pursuant to which TSRI has granted the Company a license to certain patent rights of TSRI as fully set forth in the terms of the
License Agreement (the “Licensed Rights”); 
 WHEREAS, pursuant to
Sections 3.2.1 and 3.2.2 of the License Agreement, as consideration for the Licensed Rights, the Company has agreed to issue TSRI (i) 49,130 shares (the “Initial Shares”) of the Company’s common stock, par value
$0.001 per share (the “Common Stock”), on the Execution Date, and (ii) following the Execution Date, concurrently with each closing of any equity financing of the Company (each, a “Financing
Closing”), but only until such time as the Company has raised at least $[...***...] in gross proceeds in the aggregate (inclusive of the gross proceeds raised by the Company in its Series A Preferred Stock equity financing
as of the Execution Date), the Company has agreed to issue to TSRI such additional number of shares of Common Stock (the “Additional Shares” and together with the Initial Shares, the
“Shares”) as is [...***...]% of the Outstanding Shares as of the date of such Financing Closing (provided, however, that if the gross proceeds received by the Company from any Financing Closing, together with the
gross proceeds from all preceding Financing Closings and the proceeds raised by the Company in its Series A Preferred Stock equity financing as of the Execution Date, exceed $[...***...], the Company shall only be obligated to issue to TSRI
such number of Additional Shares as is [...***...]% of the Outstanding Shares for the first $[...***...] in gross proceeds (the “Additional Share Limitation”)); and 

WHEREAS, the Company desires to issue the Shares and TSRI desires to acquire the Shares on the terms set
forth in this Agreement. 
 NOW, THEREFORE, IT IS HEREBY
AGREED between the parties as follows: 
  

  
 ***Confidential
Treatment Requested 

 AGREEMENT 

1.        Issuance of Common Stock. TSRI hereby agrees to acquire from
the Company, and the Company hereby agrees to issue to TSRI, (i) the Initial Shares and (ii) subject to the provisions below, the Additional Shares. The Company acknowledges that the issuance of the Shares to TSRI is irrevocable and non-refundable, and is not conditioned upon (a) whether the Company achieves any success with its licensing of Licensed Patent Rights, (b) whether the Company develops, uses or sells any Licensed Products,
or (c) any other thing or event except as expressly described in Section 3.2 of the License Agreement. TSRI acknowledges and agrees that upon the issuance to TSRI of the Initial Shares, the Company’s obligations under Section 3.2
of the License Agreement with respect to the number of shares of its Common Stock to be issued to TSRI within [...***...] after the Effective Date shall be satisfied, and that upon the issuance to TSRI of Additional Shares concurrently with
each Financing Closing as provided for herein, the Company’s obligations under Section 3.2 of the License Agreement with respect to the number of shares of its Common Stock to be issued to TSRI upon each Financing Closing shall be
satisfied. The closing of the issuance and acquisition of the Initial Shares (the “Initial Closing”) shall occur at the offices of the Company immediately following execution of this Agreement, or at such other time
and place as the parties may mutually agree. Promptly following the Initial Closing, the Company will deliver a certificate representing the Initial Shares to TSRI at the address set forth for TSRI on the signature page hereto. Contingent and
effective upon each Financing Closing until such time as the Company has raised at least $[...***...] in gross proceeds in the aggregate (inclusive of the gross proceeds raised by the Company in its Series A Preferred Stock equity financing as
of the Execution Date), the Company shall issue a number of Additional Shares to TSRI as is [...***...]% of the Outstanding Shares as of the date of each such Financing Closing (subject to the Additional Share Limitation), it being understood
and agreed by the parties that, in connection with each acquisition of Additional Shares, the investment representations of TSRI contained in Section 4 of this Agreement shall speak as of the date of the applicable Financing Closing. Within
[...***...] after each Financing Closing, the Company will deliver a certificate representing the applicable number of Additional Shares to TSRI at the address set forth for TSRI on the signature page hereto. Notwithstanding anything herein to
the contrary, the Company’s obligations and TSRI’s rights under this Agreement with respect to the issuance and acquisition of Additional Shares upon the occurrence of any Financing Closing shall apply only to the extent such Financing
Closing is consummated before the earlier of (a) the initial public offering of the Company’s securities or (b) a sale of all or substantially all of the Company’s business to which the License Agreement relates, whether by
merger, sale of stock, sale of assets or otherwise. 
 2.         Limitations on
Transfer. 
 (a)        TSRI agrees that it shall not assign,
hypothecate, donate, encumber or otherwise dispose of any interest in the Shares except in compliance with the provisions herein and applicable securities laws. Furthermore, the Shares shall be subject to any right of first refusal in favor of the
Company or its assignees that may be contained in the Company’s Bylaws as of the Execution Date. TSRI acknowledges that it may be required to hold the Shares acquired hereunder indefinitely. During the period of time during which TSRI holds the
Shares, 

  
 ***Confidential
Treatment Requested 
 45 

 
the value of the Common Stock may increase or decrease, and any risk associated with such Common Stock and such fluctuation in value shall be borne by TSRI. 

(b)        TSRI agrees not to make any disposition of all or any portion of
the Shares unless and until: 
 (i)        there is then in effect a
registration statement under the Securities Act of 1933, as amended (the “Act”), covering such proposed disposition and such disposition is made in accordance with such registration statement; or 

(ii)        (A) the proposed transferee has agreed in writing to be bound by
the transfer restrictions and other obligations and restrictions on TSRI contained in this Agreement, (B) TSRI has notified the Company of the proposed disposition and has furnished the Company with a statement of the circumstances surrounding
the proposed disposition, and (C) if reasonably requested by the Company, TSRI has furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such Shares
under the Act. It is agreed that the Company will not require opinions of counsel for transactions made pursuant to Rule 144, except in unusual circumstances. 

3.        Restrictive Legends. All certificates representing the Shares
(or any portion thereof) shall have endorsed thereon legends in substantially the following forms (in addition to any other legend which may be required by other agreements between the parties hereto executed after the date hereof): 

(a)        “THE SHARES REPRESENTED BY
THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN
OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED”; 

(b)        “THE SHARES REPRESENTED BY
THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF FIRST REFUSAL OPTION IN FAVOR OF THE COMPANY AND/OR ITS ASSIGNEE(S) AS PROVIDED IN THE BYLAWS OF THE COMPANY”; and 

(c)        Any legend required by applicable blue sky laws.

 The Company shall be obligated to promptly reissue unlegended certificates at the request of TSRI (or a permitted transferee) if the Company has
completed its first firm commitment underwritten public offering of its Common Stock registered under the Act (the “Initial Offering”) and such holder has obtained an opinion of counsel (which counsel may be counsel to
the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of without registration, qualification and legend. Any legend endorsed on an instrument pursuant to applicable
state securities laws and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal.

  
 46 

 4.        Investment
Representations. In connection with the acquisition of the Shares, TSRI represents to the Company as follows: 

(a)        TSRI is aware of the Company’s business affairs and financial
condition and is acquiring the Shares for investment for TSRI’s own account only and not with a view to, or for resale in connection with, any “distribution” thereof within the meaning of the Act. 

(b)        TSRI understands that the Shares have not been registered under the Act by
reason of a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of TSRI’s investment intent as expressed herein. 

(c)        TSRI further acknowledges and understands that the Shares must be
held indefinitely unless the Shares are subsequently registered under the Act or an exemption from such registration is available. TSRI further acknowledges and understands that the Company is under no obligation to register the Shares. TSRI
understands that the certificate evidencing the Shares will be imprinted with the legend set forth in Section 3(a) which prohibits the transfer of the Shares unless the Shares are registered or such registration is not required in the opinion
of counsel for the Company. 
 (d)        TSRI is familiar with the
provisions of Rule 144, under the Act, as in effect from time to time, which, in substance, permit limited public resale of “restricted securities” or “control securities” acquired, directly or indirectly, from the issuer thereof
(or from an affiliate of such issuer), in a non-public offering subject to the satisfaction of certain conditions. The Shares may be resold by TSRI in certain limited circumstances subject to the provisions of
Rule 144, which requires, among other things: (i) the availability of certain public information about the Company and (ii) the resale occurring following the required holding period under Rule 144 after TSRI has purchased, and made full
payment of (within the meaning of Rule 144), the securities to be sold. 

(e)        TSRI further understands that at the time it wishes to sell the
Shares, there may be no public market upon which to make such a sale, and that, even if such a public market then exists, the Company may not be satisfying the current public information requirements of Rule 144, and in such event, TSRI would be
precluded from selling the Shares under Rule 144 even if the minimum holding period requirement had been satisfied. 

(f)        TSRI represents that TSRI is an “accredited investor” as
that term is defined in Rule 501 of Regulation D promulgated by the Securities and Exchange Commission under the Act. 

5.        Market Stand-Off
Agreement. TSRI agrees that it shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale of, any Common Stock or
other securities of the Company held by TSRI (whether now held or subsequently acquired), including the Shares (the “Restricted Securities”), during the 180-day period following the
effective date of a registration statement of the Company filed under the Act in connection with the Company’s Initial Offering (or such longer period, not to exceed 34 days after the expiration of the
180-day period, as the underwriters or the Company shall request in order to facilitate compliance by the 

  
 47 

 
underwriters with NASD Rule 2711 or NYSE Member Rule 472 or any successor or similar rule or regulation). TSRI agrees to execute and deliver such other agreements as may be reasonably requested
by the Company and/or the managing underwriters which are consistent with the foregoing or which are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect
to Restricted Securities held by TSRI until the end of such period. The underwriters of the Company’s stock are intended third party beneficiaries of this Section 5 and shall have the right, power and authority to enforce the provisions
hereof as though they were a party hereto. 
 6.        Miscellaneous. 

(a)        Notices. All notices required or permitted hereunder shall
be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the
next business day and confirmed in writing by one of the other manners set forth in this section (either (a), (c), or (d)), (c) three days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or
(d) one day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party to be notified at the address as set forth on the
signature pages hereof or at such other address or electronic mail address as such party may designate by 10 days’ advance written notice to the other parties hereto. 

(b)        Successors and Assigns. This Agreement shall inure to the
benefit of the successors and assigns of the Company and, subject to the restrictions on transfer herein set forth, be binding upon TSRI, and TSRI’s successors and assigns. 

(c)        Governing Law; Venue. This Agreement shall be governed by
and construed in accordance with the laws of the State of California, without regard to principles of conflicts of law. The parties agree that any action brought by either party to interpret or enforce any provision of this Agreement shall be
brought in, and each party agrees to, and does hereby, submit to the jurisdiction and venue of, the appropriate state or federal court located in San Diego County, California. 

(d)        Further Execution. The parties agree to take all such
further action(s) as may reasonably be necessary to carry out and consummate this Agreement as soon as practicable, and to take whatever steps may be necessary to obtain any governmental approval in connection with or otherwise qualify the issuance
of the securities that are the subject of this Agreement. 

(e)        Entire Agreement; Amendment. This Agreement constitutes the
entire agreement between the parties with respect to the subject matter hereof and supersedes and merges all prior agreements or understandings, whether written or oral. This Agreement may not be amended, modified or revoked, in whole or in part,
except by an agreement in writing signed by each of the parties hereto. 

(f)        Severability. If one or more provisions of this Agreement
are held to be unenforceable under applicable law, the parties agree to renegotiate such provision in good faith. 

  
 48 

 In the event that the parties cannot reach a mutually agreeable and enforceable replacement
for such provision, then (i) such provision shall be excluded from this Agreement, (ii) the balance of this Agreement shall be interpreted as if such provision were so excluded and (iii) the balance of this Agreement shall be
enforceable in accordance with its terms. 
 (g)        Counterparts;
Delivery by Facsimile. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original and all of which together shall constitute one instrument. Delivery of facsimile and .pdf copies of signed signature
pages will be deemed binding originals. 
 (h)        California
Corporate Securities Law. THE SALE OF THE SECURITIES WHICH ARE THE SUBJECT OF THIS AGREEMENT HAS NOT BEEN QUALIFIED WITH THE COMMISSIONER OF CORPORATIONS OF THE STATE OF CALIFORNIA AND THE ISSUANCE OF SUCH SECURITIES OR THE PAYMENT OR RECEIPT OF
ANY PART OF THE CONSIDERATION THEREFOR PRIOR TO SUCH QUALIFICATION OR IN THE ABSENCE OF AN EXEMPTION FROM SUCH QUALIFICATION IS UNLAWFUL. PRIOR TO ACCEPTANCE OF SUCH CONSIDERATION BY THE COMPANY, THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT ARE
EXPRESSLY CONDITIONED UPON SUCH QUALIFICATION BEING OBTAINED OR AN EXEMPTION FROM SUCH QUALIFICATION BEING AVAILABLE. 
 [Remainder of
Page Intentionally Left Blank] 

  
 49 

 IN WITNESS WHEREOF, the parties hereto have executed this Stock Issuance
Agreement as of the day and year first above written. 
  

					
	 SYNTHORX, INC.

		
	 By:
	 	 /s/ Court
Turner

 
					
	 Court Turner

	 President and Chief Executive Officer

		
	 Address:
	 	 11099 North Torrey Pines Road

		 	 Suite 290

		 	 La Jolla, California 92037

		 	 Fax No.: (858)
200-0821

 
					
	
	 THE SCRIPPS RESEARCH
INSTITUTE:

		
	 By:
	 	 /s/ Scott
Forrest

 
					
		
	 Name:
	 	  

	Scott Forrest
		
	 Title:
	 	Vice President, Business Development
		
	 Address:
	 	10550 North Torrey Pines Road, TPC-9
		 	La Jolla, CA 92037
		 	Attn: VP, Business Development
		 	Fax No.: (858) 784-9910

  

 EXHIBIT E 

COMMERCIAL DEVELOPMENT PLAN 

To be attached within six months after the Effective Date. 

  

 [...***...] 
  

  
 ***Confidential
Treatment Requested 
  
 

 

 EXHIBIT F 

BENCHMARKS 
 To be attached within six
months after the Effective Date. 

 EXHIBIT F 

BENCHMARKS 
  

			
	Benchmark	  	Date by which Licensee must meet
Benchmark
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]
	
[...***...]
	  	[...***...]

  
 ***Confidential
Treatment RequestedEX-10.8

 Exhibit 10.8 

***Text Omitted and Filed Separately 

with the Securities and Exchange Commission. 

Confidential Treatment Requested 

Under 17 C.F.R. Sections 200.80(c) and Rule 406 of the 

Securities Act of 1933, as amended. 
  

 
  
  

 
  
  

RESEARCH FUNDING AND OPTION AGREEMENT 
 by and
between 
 THE SCRIPPS RESEARCH INSTITUTE 
 a
California nonprofit 
 public benefit corporation 

and         

Synthorx, Inc., 
 a Delaware corporation 

 

 RESEARCH FUNDING AND OPTION AGREEMENT 

This Agreement is entered into this 31st day of July, 2014 (the “Effective
Date”), by and between The Scripps Research Institute, a California nonprofit public benefit corporation located at 10550 North Torrey Pines Road, La Jolla, California 92037 (“TSRI”), and Synthorx, Inc., a Delaware corporation,
located at 11099 North Torrey Pines Road, La Jolla, California 92037 (“Sponsor”), with respect to the facts set forth below. 

RECITALS 

A.        TSRI is engaged in fundamental scientific biomedical and biochemical research
including research relating to synthetic DNA bases, as more particularly described herein. 

B.        Sponsor is engaged in the research and development of novel proteins, RNA and DNA for
medical applications. 
 C.        Sponsor desires to provide certain funding as part of
TSRI’s research activities described above. 
 D.        Subject to any non-exclusive rights of the U.S. Government, TSRI is willing to grant to Sponsor an option to acquire rights and licenses to certain intellectual property arising from the Research Program (as defined below). 

E.        TSRI and Sponsor are parties to a license agreement dated as of the Effective Date
(the “Exclusive License Agreement”), pursuant to which TSRI has granted Sponsor an exclusive license under certain technology, materials and other information existing on the Effective Date, including TSRI’s patent and other
intellectual property rights therein (collectively, the “Existing Technology”). 
 AGREEMENT 

NOW, THEREFORE, in consideration of the mutual covenants and conditions outlined herein, TSRI and Sponsor hereby agree as follows: 

1.        DEFINITIONS. 

1.1      Affiliate. The term “Affiliate” shall mean any entity which directly or
indirectly controls, or is controlled by Sponsor. The term “control” as used herein means (a) in the case of corporate entities, direct or indirect ownership of at least fifty percent (50%) of the stock or shares entitled to vote for
the election of directors; or (b) in the case of non-corporate entities, direct or indirect ownership of at least fifty percent (50%) of the equity interest with the power to direct the management and
policies of such non-corporate entities. Unless otherwise specified, the term Sponsor includes Affiliates. 

  
 -1- 

 1.2      Agreement Number.  This
Agreement is TSRI number SFP-2143. 
 1.3      Biological
Materials.  The term “Biological Materials” shall mean any Technology in the form of tangible materials together with any progeny, mutants, or derivatives thereof developed in performance of the Research Program. 

1.4      Confidential Information.    The term “Confidential
Information” shall mean any and all proprietary information of TSRI or Sponsor which may be disclosed or made available by such party (the “disclosing party”) to the other party (the “receiving party”) at any time and from
time to time during the term hereof. The fact that a disclosing party may have marked or identified as confidential or proprietary any specific information shall be indicative that such disclosing party believes such information to be confidential
or proprietary, but the failure to so mark information shall not conclusively determine that such information was or was not considered confidential information by such disclosing party. Confidential Information shall also include any information
which, given the circumstances surrounding the disclosure, would be considered confidential by the disclosing party. Information shall not be considered confidential to the extent that the receiving party can demonstrate by competent proof that such
information: 
   a.        Is in the public domain at the time of disclosure to the
receiving party; or 
   b.        After disclosure to the receiving party, becomes
part of the public domain, by publication or otherwise, without any breach of this Agreement by the receiving party; or 

  c.        Was known to the receiving party prior to the Effective Date, which
knowledge was acquired independently and not from the disclosing party (including the disclosing party’s employees); or 

  d.        Is subsequently disclosed to the receiving party in good faith by a third
party who has a right to make such disclosure. 
 1.5      Field. The term
“Field” shall mean [...***...]. 
 1.6      Joint Technology.  The term
“Joint Technology” shall mean any Technology made or developed jointly by at least one employee or consultant of Sponsor (it being understood that, for purposes of this paragraph, no TSRI employee shall be considered a consultant of
Sponsor) and at least one employee of TSRI, as determined under principles of inventorship under US patent law. 

1.7      Patent Rights.  The term “Patent Rights” shall mean rights arising out
of or resulting from (a) U.S./PCT patent application(s) directed to the Technology; (b) divisionals, continuations, reissues, reexaminations, and extensions of any patent or application set forth in sub clause (a) above;
(c) foreign counterparts of any of the foregoing; 

  
 ***Confidential
Treatment Requested 
 -2- 

 (d) patents issued from the application(s) referenced in sub clauses (a) – (c) above; and (e) all
claims of continuations-in-part that are entitled to the benefit of the priority date of the application(s) referenced in sub clause (a) above. 

1.8      Principal Investigator.    The term “Principal Investigator”
shall mean Dr. Floyd E. Romesberg, together with such replacement persons selected in accordance with the provisions of Section 2.2 below. 

1.9      Research Program.  The term “Research Program” shall mean the research
program to be undertaken by TSRI under the direction and control of the Principal Investigator as expressly set forth on Exhibit A hereto. 

1.10    Research Tool.    The term “Research Tool” shall mean any Technology
which is designed or utilized for basic research purposes or internal drug discovery purposes and which is not utilized to produce, or incorporated into, a product. 

1.11    Technology.    The term “Technology” shall mean any invention,
discovery, know-how, biological material, software, information and data, whether patentable or not, conceived and reduced to practice during the performance of the Research Program. 

1.12    TSRI Technology.    The term “TSRI Technology” shall mean any
Technology, made or developed solely by one or more employees of TSRI, as determined under principles of inventorship under U.S. patent law. 

2.        CONDUCT OF RESEARCH PROGRAM. 

2.1      Conduct of Research Program.  TSRI hereby agrees to use [...***...] to
perform the Research Program subject to the provisions of this Agreement. Notwithstanding the foregoing, TSRI makes no warranties or representations regarding its ability to achieve, nor shall it be bound to accomplish, any particular research
objective or results. 
 2.2      Supervision of Research Program.  TSRI agrees that
the Research Program at TSRI shall be conducted by or under the direct supervision of the Principal Investigator. In the event that the Principal Investigator leaves TSRI, or terminates his/her involvement in the Research Program, TSRI shall use its
best efforts to find a replacement Principal Investigator acceptable to Sponsor, which acceptance shall not be unreasonably withheld. In the event that TSRI shall fail to appoint a replacement Principal Investigator reasonably acceptable to Sponsor,
Sponsor shall have a right to terminate this Agreement upon delivery to TSRI of written notice of termination pursuant to this Section 2.2, which notice must be delivered to TSRI not more than ninety (90) days after delivery by TSRI to
Sponsor of the name of the proposed replacement Principal Investigator. 

2.3      Reports.  TSRI and the Principal Investigator shall keep complete and accurate
records of the results of the Research Program. TSRI agrees to provide oral 

  
 ***Confidential
Treatment Requested 
 -3- 

 
reports on a monthly basis, and Sponsor shall have the right, upon reasonable request from time to time, to discuss with TSRI, the Principal Investigator and other appropriate TSRI personnel, in
person or otherwise, the Research Program and the results thereof. TSRI agrees that within [...***...] following the last day of each calendar year during the term of this Agreement, TSRI shall furnish Sponsor with a written report summarizing
the results of the research included within the scope of the Research Program conducted by TSRI, during the immediately preceding calendar year, including but not limited to all data, conclusions, results, observations and a detailed description of
all procedures. Subject to Section 5.1, all such reports shall be treated as Confidential Information by Sponsor. In the event that Sponsor identifies any Technology disclosed in such report as to which it would like to exercise its option and
which has not been previously disclosed to Sponsor by TSRI in accordance with Section 3.2, Sponsor shall notify TSRI of such Technology in writing. Promptly following such notification, TSRI shall provide Sponsor with a Technology Disclosure in
accordance with Section 3.2. 
 2.4      Financial and Staffing Obligations 

  a.        Contributions of Parties to Research Program. Contributions in the
form of financial support, equipment, personnel, technology and other necessary components for the conduct of the Research Program shall be made by the parties in accordance with the terms set forth on Exhibit B. All payments due to TSRI by
Sponsor shall be payable in U.S. Dollars in quarterly installments in advance, within [...***...] of the dates set forth in the following payment schedule: 
  

							
	 1st payment:
	    	 due: [.***.]
	  		  	 amount (USD): $[.***.]

	 2nd payment:
	    	 due: [.***.]
	  		  	 amount (USD): $[.***.]

	 3rd payment:
	    	 due: [.***.]
	  		  	 amount (USD): $[.***.]

	 4th payment:
	    	 due: [.***.]
	  		  	 amount (USD): $[.***.]

 The amounts specified above include all expense, overhead and other related costs due by Sponsor to TSRI in connection
with the Research Program, and no other amounts shall be due or payable by Sponsor to TSRI or the Principal Investigator for performance of the Research Program. Each payment must reference the Research Project title, Agreement Number and Principal
Investigator for purposes of identification. Payments under this Section 2.4.a shall be sent to: 
 The Scripps Research
Institute 
 10550 North Torrey Pines Road, TPC-7 

La Jolla, California 92037 

Attn: Vice President, Sponsored Programs 

Fax No.: (858) 784-8037 

  
 ***Confidential
Treatment Requested 
 -4- 

 With a copy of Sponsor’s notice of payment or other accompanying correspondence
to:     
 The Scripps Research Institute 

10550 North Torrey Pines Road, TPC-9 

La Jolla, California 92037 

Attn: Director, Technology Development 

Fax No.: (858) 784-9910 

TSRI shall not be obligated to perform any of the research specified herein or to take any other action required under this Agreement if the funding is
not provided as set forth in Exhibit B and in accordance with the payment schedule as set forth in this Section 2.4.a. Furthermore, should Sponsor fail to make the first payment to TSRI in accordance with this Section 2.4.a., TSRI
shall have the right to immediately terminate this Agreement and this Agreement shall be null and void ab initio. 

  b.        Capital Equipment.    Equipment purchased by
TSRI with funds provided by Sponsor shall be the property of TSRI. All capital equipment provided under this Agreement by Sponsor for the use of TSRI remains the property of the Sponsor unless other disposition is mutually agreed upon in writing by
the Parties. If title to this equipment remains with the Sponsor, Sponsor is responsible for maintenance and repair of the equipment, insuring the equipment against damage or loss, and the costs of its transportation to and from the site where it
will be used. 
   c.        Indirect Cost
Adjustment.    TSRI shall have the right to adjust the payment amounts referenced above to reflect changes in the indirect cost rate negotiated between TSRI and the U.S. Government and that will be in effect during the
quarter that the work is performed. TSRI will notify Sponsor in writing of any change in the indirect cost rate before the effective date of such change. The corresponding direct costs will remain fixed as specified in Exhibit B. 

3.        OPTION FOR LICENSE. 

Notwithstanding the provisions of Sections 3.1 through 3.6 or any other provision of this Agreement to the contrary, TSRI and Sponsor agree that
the Patent Rights and Technology (including, without limitation, Joint Technology) are exclusively licensed to Sponsor, together with the Existing Technology, pursuant to the Exclusive License Agreement on the terms and conditions set forth therein.
For so long as the Exclusive License Agreement remains in effect: (a) all Patent Rights and Technology (including, without limitation, Joint Technology) arising under this Agreement are automatically deemed included in the subject matter
exclusively licensed to Sponsor under the Exclusive License Agreement, effective upon Sponsor’s delivery of written notice to TSRI pursuant to the first sentence of Section 3.4, and without any other action on the part of either party
pursuant to Section 3.3, 3.4 or 3.6 or otherwise; (b) Section 3.2 hereof shall continue in full force and effect; and (c) preparation, filing, 

  
 -5- 

 
prosecution and maintenance of Patent Rights shall be governed by the Exclusive License Agreement (and not Section 3.5 hereof). 

3.1      Grant of Option. Subject to the terms of this Agreement and the reservation of rights
specified in Sections 4.2 and 4.3, TSRI hereby grants to Sponsor: 

  a.        an exclusive option (the “Option”) to acquire an exclusive,
worldwide license, including the right to sublicense, under TSRI’s rights in the Patent Rights and/or Biological Materials, to make, have made, use, offer for sale, sell, have sold and import products, processes and Biological Material in the
Field. In the event that a product or process utilizes a Research Tool, such Research Tool shall be made available to Sponsor solely on a non-exclusive basis. 

  b.        a non-exclusive, royalty-free, non-transferable license to make and use Technology solely for Sponsor’s internal research purposes during the performance of the Research Program. Any transfer of materials to Sponsor under this
Section 3.1(b) shall require the execution of a Material Transfer Agreement. The terms of such Material Transfer Agreement shall be materially consistent with the form Material Transfer Agreement attached hereto as Exhibit C. 

3.2      Disclosure of Technology. After Principal Investigator submits an invention disclosure
covering any Technology to TSRI’s Office of Technology Development, TSRI shall disclose such Technology in writing to Sponsor (the “Technology Disclosure”). TSRI shall use reasonable efforts to provide a Technology Disclosure that
contains sufficient detail to (i) enable both parties to determine whether or not the particular Technology is TSRI Technology or Joint Technology; and (ii) enable Sponsor to appreciate the significance of such Technology and to evaluate
the advisability of exercising the option granted hereunder with respect to such Technology. All such Technology Disclosures shall be maintained in confidence by Sponsor. 

3.3      Option. Sponsor shall have a period of [...***...] from receipt of the Technology
Disclosure from TSRI (“Option Period”), within which to exercise its Option with respect to the particular Technology disclosed therein. 

3.4      Exercise of Option. Sponsor shall exercise its Option by delivering to TSRI a written
notice within the Option Period which specifies the particular Technology for which the Option is being exercised. Upon such notification, Sponsor and TSRI shall have a period of [...***...] within which to negotiate a definitive license
agreement. 

3.5                         
                   Patent Filings. TSRI shall direct and control the preparation, filing and prosecution of patent applications and patents within
the Patent Rights. As consideration for the Option, [...***...]. Payment shall be made within [...***...] 

  
 ***Confidential
Treatment Requested 
 -6- 

 
[...***...] after Sponsor receives an invoice therefor. Failure of Sponsor to pay patent fees and expenses as set forth above shall immediately relieve TSRI from its obligation to incur any
further patent fees and expenses. Sponsor’s obligation to [...***...] shall survive the termination or expiration of this Agreement. Both parties hereto agree that TSRI may, at its sole discretion, utilize TSRI’s Office of Patent
Counsel in lieu of or in addition to independent counsel for patent prosecution and maintenance of patent application(s). Sponsor shall have full rights of consultation with the patent attorney so selected on all matters relating to patent
application(s). 
 3.6      Joint Technology. The parties hereby agree that in the event that
the disclosed Technology is Joint Technology and Sponsor neither exercises its Option to such Joint Technology nor has a license to such Joint Technology under the Exclusive License Agreement (i.e., if the Exclusive License Agreement has
terminated), both Parties shall (i) have no further obligations to each other with respect to such Joint Technology and any resulting Patent Rights; and (ii) be free to independently license or otherwise dispose of their rights to such
Joint Technology and any resulting Patent Rights on a worldwide basis without accounting to the other Party. 

4.        INTERESTS AND RIGHTS IN INTELLECTUAL PROPERTY. 

4.1      Title. TSRI shall retain sole ownership and title to TSRI Technology and to all
intellectual property rights related thereto. TSRI shall, in the good faith exercise of its discretion, undertake reasonable efforts to preserve and maintain its ownership and title as TSRI deems appropriate. Ownership of and title to Joint
Technology shall be vested jointly in TSRI and Sponsor, with each owning an undivided interest therein. 

4.2      Governmental Interest. TSRI and Sponsor acknowledge that TSRI has received, and expects
to continue to receive, funding from the United States Government in support of TSRI’s research activities. TSRI and Sponsor acknowledge and agree that their respective rights and obligations pursuant to this Agreement shall be subject to the
rights of the United States Government, existing and as amended, which may arise or result from TSRI’s receipt of research support from the United States Government, including but not limited to, 37 CFR 401, the NIH Grants Policy Statement and
the NIH Guidelines for Obtaining and Disseminating Biomedical Research Resources. 

4.3      Reservation of Rights. TSRI reserves the right to [...***...]. In addition, TSRI
reserves the right to [...***...]. TSRI shall have no obligation to notify or inform Sponsor of such use or licenses. 

  
 ***Confidential
Treatment Requested 
 -7- 

 5.        CONFIDENTIALITY AND
PUBLICATION. 
 5.1      Treatment of Confidential Information. The parties agree that
during [...***...] of this Agreement, the receiving party will (a) maintain in confidence all Confidential Information to the same extent the receiving party maintains its own proprietary information; (b) not disclose such
Confidential Information to any third party without the prior written consent of the disclosing party; and (c) not use such Confidential Information for any purpose except those permitted by this Agreement (and, if and to the extent applicable,
the Exclusive License Agreement). 
 If the receiving party is required to disclose Confidential Information by law or court order, the receiving
party shall limit the same to the minimum required to comply with the law or court order; provided that, prior to making such disclosure the receiving party shall notify the disclosing party, not later than [...***...] (or such shorter period
of time as may be reasonably practicable under the circumstances) before the disclosure, and shall, at the disclosing party’s request and expense, cooperate with the Disclosing Party’s efforts to seek confidential treatment of the
Confidential Information to be disclosed and/or to obtain a protective or other order, including extensions of time and the like, with respect to such disclosure. 

5.2      Publications. Sponsor acknowledges that it is the general policy of TSRI to encourage
publication of research results in technical or scientific journals; and Sponsor agrees that TSRI shall have a right to publish in accordance with its general policy. TSRI shall submit to Sponsor copies of proposed publications which describe
Technology and afford Sponsor a period of [...***...] to review the publication to (i) ascertain whether Sponsor’s Confidential Information would be disclosed by the publication; and (ii) ascertain whether or not submission or
presentation of the publication would preclude the parties from obtaining patent rights claiming Technology disclosed therein unless an application is filed with relevant patent authorities. If such publication discloses Sponsor’s Confidential
Information and upon Sponsor’s written request, TSRI shall remove such Confidential Information or delay publication for up to an additional [...***...] to allow Sponsor to protect its Confidential Information by filing a patent
application(s). In the event that Sponsor identifies any potentially patentable Technology with respect to which it wishes to file, or have TSRI file (as applicable), patent application(s), Sponsor shall notify TSRI of such in writing. Upon such
notification, TSRI shall, at its option, either delete the enabling portion of the proposed publication or presentation, or withhold publication or delay presentation for up to an additional [...***...] to allow filing of patent
application(s). Absent receipt by TSRI of any written instruction by Sponsor within the [...***...] period, TSRI shall be free to publish the proposed publication. 

5.3      Publicity. Except as otherwise provided herein or required by law, no party shall
originate any publication, news release or other public announcement, written or oral, whether in the public press, stockholders’ reports, or otherwise, relating to this 

  
 ***Confidential
Treatment Requested 
 -8- 

 
Agreement or to the performance hereunder without the prior written approval of the other party, which approval shall not be unreasonably withheld. Scientific publications published in accordance
with Section 5.2 of this Agreement shall not be construed as publicity governed by this Section 5.3. 

6.        WARRANTIES. 

6.1      Limited Warranty. TSRI hereby represents and warrants that it has full right and power to
enter into this Agreement. TSRI MAKES NO OTHER WARRANTIES CONCERNING PATENT RIGHTS, TECHNOLOGY, RESEARCH TOOLS, BIOLOGICAL MATERIALS OR ANY OTHER MATTER WHATSOEVER, INCLUDING WITHOUT LIMITATION, ANY EXPRESS OR IMPLIED WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT OF THIRD PARTY RIGHTS OR ARISING OUT OF COURSE OF CONDUCT OR TRADE CUSTOM OR USAGE, AND TSRI DISCLAIMS ALL SUCH EXPRESS OR IMPLIED
WARRANTIES. TSRI MAKES NO WARRANTY OR REPRESENTATION AS TO THE VALIDITY OR SCOPE OF PATENT RIGHTS, OR THAT ANY PRODUCT, PROCESS, SERVICE, BIOLOGICAL MATERIAL, OR RESEARCH TOOL WILL BE FREE FROM AN INFRINGEMENT ON PATENTS OR OTHER INTELLECTUAL
PROPERTY RIGHTS OF THIRD PARTIES, OR THAT NO THIRD PARTIES ARE IN ANY WAY INFRINGING UPON ANY PATENT RIGHTS, TECHNOLOGY, RESEARCH TOOLS OR BIOLOGICAL MATERIALS COVERED BY THIS AGREEMENT. FURTHER, TSRI HAS MADE NO INVESTIGATION AND
MAKES NO REPRESENTATION THAT THE PATENT RIGHTS, RESEARCH TOOLS OR BIOLOGICAL MATERIALS ARE SUITABLE FOR SPONSOR’S PURPOSES. 
 IN NO EVENT SHALL
EITHER PARTY BE LIABLE TO THE OTHER PARTY FOR ANY INDIRECT, SPECIAL, INCIDENTAL, EXEMPLARY OR CONSEQUENTIAL DAMAGES (INCLUDING, WITHOUT LIMITATION, DAMAGES FOR LOSS OF PROFITS OR EXPECTED SAVINGS OR OTHER ECONOMIC LOSSES, OR FOR INJURY TO PERSONS OR
PROPERTY) ARISING OUT OF OR IN CONNECTION WITH THIS AGREEMENT OR ITS SUBJECT MATTER. TSRI’S AGGREGATE LIABILITY, IF ANY, FOR ALL DAMAGES OF ANY KIND RELATING TO THIS AGREEMENT OR ITS SUBJECT MATTER SHALL NOT EXCEED THE AMOUNT PAID BY SPONSOR TO
TSRI UNDER THIS AGREEMENT. THE FOREGOING EXCLUSIONS AND LIMITATIONS SHALL APPLY TO ALL CLAIMS AND ACTIONS OF ANY KIND AND ON ANY THEORY OF LIABILITY, WHETHER BASED ON CONTRACT, TORT (INCLUDING, BUT NOT LIMITED TO NEGLIGENCE OR STRICT LIABILITY), OR
ANY OTHER GROUNDS, AND REGARDLESS OF WHETHER A PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, AND NOTWITHSTANDING ANY FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY. THE PARTIES FURTHER AGREE THAT EACH WARRANTY DISCLAIMER, EXCLUSION
OF DAMAGES OR OTHER LIMITATION OF LIABILITY HEREIN IS INTENDED TO BE SEVERABLE AND INDEPENDENT OF THE OTHER PROVISIONS SINCE THEY EACH REPRESENT SEPARATE ELEMENTS OF RISK ALLOCATION BETWEEN THE PARTIES. 

7.        TERM AND TERMINATION. 

7.1      Term. Unless terminated sooner, the initial term of this Agreement shall commence on the
Effective Date and shall continue until the earlier of (a) the 

  
 -9- 

 first (1st) anniversary of the Effective
Date, and (b) the completion of the Research Program, unless extended by written mutual agreement of the parties. 

7.2      Termination by Mutual Agreement.     This Agreement may be terminated
at any time upon the mutual written agreement of the parties. In the absence of an agreement to the contrary, no such termination shall have the effect of relieving Sponsor of its monetary obligations to fund the Research Program which shall have
accrued up and to the date of such termination. 
 7.3      Termination Upon Default. Except as
specified in Section 7.4, the failure of a party to perform any obligation required of it to be performed hereunder and the failure to cure within sixty (60) days (or, in the case of any failure by Sponsor to make any payment hereunder
when due, within thirty (30) days) after receipt of notice from the other party specifying in reasonable detail the nature of such default, shall constitute an event of default hereunder. Upon the occurrence of an event of default which is not
cured within the applicable notice period, the non-defaulting party may deliver to the defaulting party written notice of intent to terminate, such termination to be effective upon the date set forth in such
notice. Such termination rights shall be in addition to and not in substitution for any other remedies that may be available to the non-defaulting party serving such notice against the defaulting party.
Termination pursuant to this Section 7.3 shall not relieve the defaulting party of liability and damages to the non-defaulting party for breach of this Agreement. Waiver by any party of a single default
or a succession of defaults shall not deprive such party of any right to terminate this Agreement arising by reason of any subsequent default. 

7.4      Termination Upon Insolvency.     This Agreement may be terminated by a
party upon written notice of termination to the other party (“Insolvent Party”) in the event of the filing of bankruptcy by the Insolvent Party, or the appointment of a receiver of any of the Insolvent Party’s assets, or the making by
the Insolvent Party of any assignment for the benefit of creditors, or the institution of any involuntary bankruptcy proceedings against the Insolvent Party under any bankruptcy law that are not dismissed within sixty (60) days after
institution. Termination shall be effective upon the date specified in this notice. 

7.5      Effect of Expiration or Termination. 

  a.        Termination Upon Default of Sponsor.     Upon
the termination of this Agreement by reason of a default by Sponsor, neither party shall have any further rights or obligations with respect to this Agreement, other than the rights and obligations of the parties that accrued prior to the effective
date of such termination (including, without limitation, the obligation of Sponsor to make any and all final payments accrued prior to the date of termination and the obligation of the parties to make all reports required hereunder), and except as
provided below. Upon such termination of this Agreement, the parties shall continue to abide by their non-disclosure obligations as described in Section 5.1 and each party hereto shall fulfill any other
obligations incurred prior to such termination. Any such termination of this Agreement shall not constitute the termination of any license or any other agreements between the parties which are then in effect (such as, but not limited to, the 

  
 -10- 

 
Exclusive License Agreement) except as expressly provided therein. In addition, upon such termination, Sponsor’s Option under Section 3.1 shall be deemed automatically cancelled, and
Sections 4, 6, 7, 8 and 9 shall survive any such termination. 

  b.        Expiration or Termination upon Default of TSRI. Upon the
expiration of this Agreement at its regularly scheduled expiration date, or upon a termination of this Agreement on account of a default by TSRI, then TSRI shall make the disclosures required by Section 3.2 for Technology conceived or reduced
to practice up to the date of said expiration or termination; Sponsor shall have the right to exercise its option with respect to said Technology in accordance with the schedule and procedures specified in Sections 3.3 and 3.4 above; and any non-exclusive licenses that have been granted under Section 3.1 shall survive. Additionally, each party shall perform all other obligations up to the date of said expiration or termination; the parties shall
continue to abide by their non-disclosure obligations described in Section 5.1; and any previously existing license agreements or other agreements between the parties (such as, but not limited to, the
Exclusive License Agreement) shall continue in effect. No such expiration or termination of this Agreement shall affect the rights and obligations of the parties that accrued prior to the effective date of such expiration or termination. In
addition, upon such expiration or termination, Sections 4, 6, 7, 8 and 9 shall survive. 

8.        ASSIGNMENT; SUCCESSORS. 

8.1      Assignment. Any and all assignments of this Agreement or any rights granted hereunder by
Sponsor without the prior written consent of TSRI are void, except that, without the prior written consent of TSRI, (a) Sponsor may assign this Agreement and its rights and obligations hereunder to an Affiliate of Sponsor; and (b) Sponsor
may assign this Agreement and its rights and obligations hereunder in connection with the transfer or sale of all or substantially all of Sponsor’s business or assets to which this Agreement relates to a third party, whether by merger, sale of
stock, sale of assets or otherwise, subject to Section 8.2 hereof. 
 8.2      Binding Upon
Successors and Assigns.   Subject to the limitations on assignment set forth herein, this Agreement shall be binding upon and inure to the benefit of any successors in interest and assigns of TSRI and Sponsor. Any such successor to or
assignee of a party’s interest shall expressly assume in writing the performance of all the terms and conditions of this Agreement to be performed by such party and such written assumption shall be delivered to the other Party. 

9.        GENERAL PROVISIONS. 

9.1      Independent Contractors.     The relationship between TSRI and
Sponsor is that of independent contractors. TSRI and Sponsor are not joint venturers, partners, principal and agent, master and servant, employer or employee, and have no other relationship other than independent contracting parties. TSRI and
Sponsor shall have no power to bind or obligate each other in any manner, other than as is expressly set forth in this Agreement. 

  
 -11- 

 9.2      Arbitration. Any controversy or claim
arising out of or relating to this Agreement, or the breach thereof, shall be settled by binding confidential arbitration in accordance with the Commercial Arbitration Rules of the American Arbitration Association (“AAA”), and the
procedures set forth below. In the event of any inconsistency between the Rules of AAA and the procedures set forth below, the procedures set forth below shall control. Judgment upon the award rendered by the arbitrators may be enforced in any court
having jurisdiction thereof. 
   a.        Location.   The
location of the arbitration shall be in the County of San Diego. TSRI and Sponsor hereby irrevocably submit to the exclusive jurisdiction and venue of the American Arbitration Association arbitration panel selected by the parties and located in San
Diego County, California for any dispute regarding this Agreement, and to the exclusive jurisdiction and venue of the federal and state courts located in San Diego County, California for any action or proceeding to enforce an arbitration award or as
otherwise provided in Section 9.2 e below, and waive any right to contest or otherwise object to such jurisdiction or venue. 

  b.        Selection of Arbitrators.       The
arbitration shall be conducted by a panel of three neutral arbitrators who are independent and disinterested with respect to the parties, this Agreement, and the outcome of the arbitration. Each party shall appoint one neutral arbitrator, and these
two arbitrators so selected by the parties shall then select the third arbitrator, and all arbitrators must have at least ten (10) years experience in mediating or arbitrating cases regarding the same or substantially similar subject matter as
the dispute between TSRI and Sponsor. If one party has given written notice to the other party as to the identity of the arbitrator appointed by the party, and the party thereafter makes a written demand on the other party to appoint its designated
arbitrator within the next ten days, and the other party fails to appoint its designated arbitrator within ten days after receiving said written demand, then the arbitrator who has already been designated shall appoint the other two arbitrators.

   c.        Discovery. The arbitrators shall decide any disputes and
shall control the process concerning these pre-hearing discovery matters. Pursuant to the Rules of AAA, the parties may subpoena witnesses and documents for presentation at the hearing. 

  d.        Case Management. Prompt resolution of any dispute is important to
both parties; and the parties agree that the arbitration of any dispute shall be conducted expeditiously. The arbitrators are instructed and directed to assume case management initiative and control over the arbitration process (including scheduling
of events, pre-hearing discovery and activities, and the conduct of the hearing), in order to complete the arbitration as expeditiously as is reasonably practical for obtaining a just resolution of the
dispute. 

e.                         
                                Remedies.     The arbitrators
may grant any legal or equitable remedy or relief that the arbitrators deem just and equitable, to the same extent that 

  
 -12- 

 remedies or relief could be granted by a state or federal court, provided however, that no punitive
damages may be awarded. No court action shall be maintained seeking punitive damages. The decision of any two of the three arbitrators appointed shall be binding upon the parties. Notwithstanding anything to the contrary in this Agreement, prior to
or while an arbitration proceeding is pending, either party has the right to seek and obtain injunctive and other equitable relief from a court of competent jurisdiction to enforce that party’s rights hereunder. In addition, no claim, dispute
or controversy that concerns the validity, enforceability, scope or infringement of a patent, trademark or copyright shall be subject to arbitration or any other provision of this Section 9.2. 

  f.        Expenses. The expenses of the arbitration, including the
arbitrators’ fees, expert witness fees, and attorney’s fees, may be awarded to the prevailing party, in the discretion of the arbitrators, or may be apportioned between the parties in any manner deemed appropriate by the arbitrators.
Unless and until the arbitrators decide that one party is to pay for all (or a share) of such expenses, both parties shall share equally in the payment of the arbitrators’ fees as and when billed by the arbitrators. 

  g.        Confidentiality. Except as set forth below and as necessary to
obtain or enforce a judgment upon any arbitration award, the parties shall keep confidential the fact of the arbitration, the dispute being arbitrated, and the decision of the arbitrators. Notwithstanding the foregoing, the parties may disclose
information about the arbitration to persons who have a need to know, such as directors, trustees, management employees, witnesses, experts, investors, attorneys, lenders, insurers, and others who may be directly affected. Additionally, if a party
has stock which is publicly traded, the party may make such disclosures as are required by applicable securities laws, but will use commercially reasonably efforts to seek confidential treatment for such disclosure. 

9.3      Entire Agreement; Modification.     This Agreement and all of the
attached Exhibits set forth the entire agreement and understanding between the parties as to the subject matter hereof, and supersede all prior or contemporaneous written or oral agreements, excluding the Exclusive License Agreement. There shall be
no amendments or modifications to this Agreement, except by a written document which is signed by both parties. 

9.4      California Law.     This Agreement shall be construed and enforced in
accordance with the laws of the State of California notwithstanding any conflicts or choice of laws provisions. 

9.5      No Use of Name.     The use of the name “The Scripps Research
Institute”, “Scripps”, “TSRI” or any variation thereof in connection with the advertising, sale or performance of products, processes, services, Biological Materials or Research Tools is expressly prohibited. 

9.6      Headings.     The headings for each article and section in this
Agreement have been inserted for the convenience of reference only and are not intended to limit or expand on the meaning of the language contained in the particular article or section. 

  
 -13- 

 9.7        Severability.
  Should any one or more of the provisions of this Agreement be held invalid or unenforceable by a court of competent jurisdiction, it shall be considered severed from this Agreement and shall not serve to invalidate the remaining
provisions thereof. The parties shall make a good faith effort to replace any invalid or unenforceable provision with a valid and enforceable one such that the objectives contemplated by them when entering this Agreement may be realized. 

9.8        No Waiver.   Any delay in enforcing a party’s rights under
this Agreement or any waiver as to a particular default or other matter shall not constitute a waiver of such party’s rights to the future enforcement of its rights under this Agreement, excepting only as to an express written and signed waiver
as to a particular matter for a particular period of time. 
 9.9        Notices. Any
notices required by this Agreement shall be in writing, shall specifically refer to this Agreement and shall be sent by registered or certified airmail, postage prepaid, or by telefax, telex or cable, charges prepaid, or by overnight courier,
postage prepaid, and shall be forwarded to the respective addresses set forth below unless subsequently changed by written notice to the other party: 
  

			
	 FOR TSRI:
	  	 The Scripps Research Institute

		  	 10550 North Torrey Pines Road, TPC-9

		  	 La Jolla, California 92037

		  	 Attn: Vice President, Business Development

		  	 Fax No.: (858) 784-9910

		
	 With a copy to:
	  	 The Scripps Research Institute

		  	 10550 North Torrey Pines Road, TPC-8

		  	 La Jolla, California 92037

		  	 Attention: Chief Business Counsel

		  	 Fax No.: (858) 784-9910

		
	 FOR SPONSOR:
	  	 Synthorx, Inc.

		  	 11099 North Torrey Pines Road, Suite 290

		  	 La Jolla, California 92037

		  	 Attn: President and Chief Executive Officer

		  	 Fax No.: (858) 750-4701

 Notices shall be deemed delivered upon the earlier of (i) when received; (ii) three (3) days after
deposit into the U.S. mail; (iii) the date notice is sent via telefax, telex or cable; or (iv) the day immediately following delivery to an overnight courier guaranteeing next-day delivery (except
Sunday and holidays). 
 9.10    Compliance with U.S. Laws. Nothing contained in this Agreement shall
require or permit TSRI or Sponsor to do any act inconsistent with the requirements of any 

  
 -14- 

 
United States law, regulation or executive order as the same may be in effect from time to time. 

9.11        Indemnity.     Sponsor shall indemnify, defend (by
counsel reasonably acceptable to TSRI) and hold harmless TSRI and any parent, subsidiary or other affiliated entity of TSRI and their trustees, directors, officers, employees, scientists, agents, successors, assigns and other representatives
(collectively, the “Indemnitees”) from and against all claims, suits, actions, damages, liabilities, losses and other expenses, including without limitation reasonable attorney’s fees, expert witness fees and costs incurred by or
asserted against the Indemnitees, whether or not a lawsuit or other proceeding is filed (collectively “Claim”), that arise out of or relate to any third party allegations or suits regarding Sponsor’s use of the Technology or the
exercise of its non-exclusive license rights under Section 3.1.b. Sponsor shall not enter into any settlement of such Claims that imposes any obligation on TSRI, that does not unconditionally release TSRI
from all liability or that would have an adverse effect on TSRI’s reputation or business without TSRI’s prior written consent. In the event an Indemnitee seeks indemnification with respect to a Claim under this Section 9.11, it shall
notify Sponsor in writing of such Claim as soon as reasonably practicable after it receives notice of such Claim, shall permit Sponsor to assume direction and control of the defense of the Claim (including the right to settle the Claim solely for
monetary consideration, subject to the limitations of the preceding sentence) using counsel selected by Sponsor and reasonably acceptable to TSRI, and shall cooperate as reasonably requested (at the expense of Sponsor) in the defense of the Claim.
Notwithstanding the above, Indemnitees, [...***...], shall have the right to retain separate independent counsel to assist in defending any such Claims. In the event Sponsor fails to promptly indemnify and defend such Claims and/or pay
Indemnitees’ expenses as provided above, Indemnitees shall have the right to defend themselves, and in that case, [...***...] of each of Indemnitees’ written requests. This indemnity shall be a direct payment obligation and not
merely a reimbursement obligation of Sponsor to Indemnitees. 

  
 ***Confidential
Treatment Requested 
 -15- 

 IN WITNESS WHEREOF, the parties have executed this Agreement by their duly authorized
representatives as of the date set forth above. 
  

					
	 TSRI:
	 		 	 SPONSOR:

			
	 THE SCRIPPS RESEARCH INSTITUTE
	 		 	 SYNTHORX, INC.

		
	 By: /s/
Scott Forrest                     
	 	 By:  /s/ Court
Turner                          

		
	 Title: VP, Business Development
	 	 Title: President and
CEO                   

  
 -16- 

 EXHIBIT A 

RESEARCH PROGRAM 
 Background

 [...***...] 

  
 ***Confidential
Treatment Requested 

 [...***...] 

Literature Cited 
  

	1.	 DA Malyshev, K Dhami, HT Quach, T Lavergne, P Ordoukhanian, A Torkamani, FE Romesberg. Efficient and
sequence-independent replication of DNA containing a third base pair establishes a functional six-letter genetic alphabet. (2012) Proc Natl Acad Sci USA, 109:12005-12010. PMCID: 3409741.

	2.	 YJ Seo, S Matsuda, FE Romesberg. Transcription of an expanded genetic alphabet. (2009) J Am Chem Soc,
131:5046-5047. PMCID: PMC2728119. 

	3.	 HH Winkler, HE Neuhaus. Non-mitochondrial ATP transport. (1999) Trends
Biochem Sci, 24:64-68. 

	4.	 H Amiri, O Karlberg, SG Andersson. Deep origin of plastid/parasite ATP/ADP translocases. (2003) J Mol Evol, 56:137-150. 

	5.	 TP Hatch, E Al-Hossainy, JA Silverman. Adenine nucleotide and lysine transport
in Chlamydia psittaci. (1982) J Bacteriol, 150:662-670. 

	6.	 HH Winkler. Rickettsial permeability: an ADP-ATP transport system.
(1976) J Biol Chem, 251:389-396. 

	7.	 M Horn, M Wagner. Bacterial endosymbionts of free-living amoebae. (2004) J Eukaryot Microbiol, 5:509-514. 

	8.	 I Haferkamp, S Schmitz-Esser, M Wagner, N Neigel, M Horn, HE Neuhaus. Tapping the nucleotide pool of the host: novel
nucleotide carrier proteins of Protochlamydia amoebophila. (2006) Mol Microbiol, 60:1534-1545. PMCID: 1513512. 

	9.	 B Miroux, JE Walker. Over-production of proteins in Escherichia coli: mutant hosts that allow synthesis of some
membrane proteins and globular proteins at high levels. (1996) J Mol Biol, 260:289-298. 

	10.	 I Haferkamp, N Linka. Functional expression and characterisation of membrane transport proteins. (2012) Plant
Biol, 14:675-690. 

	11.	 M Ast, A Gruber, S Schmitz-Esser, HE Neuhaus, PG Kroth, M Horn, I Haferkamp. Diatom plastids depend on nucleotide
import from the cytosol. (2009) Proc Natl Acad Sci USA, 106:3621-3626. PMCID: 2642474. 

  
 ***Confidential
Treatment Requested 

	12.	 T Lavergne, DA Malyshev, FE Romesberg. Major groove substituents and polymerase recognition of a class of
predominantly hydrophobic unnatural base pairs. (2012) Chem Eur J, 18:1231-1239. PMCID: 3693734. 

	13.	 L Li, M Degardin, T Lavergne, D Malyshev, K Dhami, P Ordoukhanian, FE Romesberg. Natural-like replication of an
unnatural base pair for the expansion of the genetic alphabet and biotechnology applications. (2014) J Am Chem Soc, 136:826-829. 

	14.	 H Hashimoto, JE Pais, X Zhang, L Saleh, Z-Q Fu, N Dai, IR Correa, Y Zheng, X
Cheng. Structure of a Naegleria Tet-like dioxygenase in complex with 5-methylcytosine DNA. (2014) Nature, 506:391-395.

	15.	 YJ Seo, DA Malyshev, T Lavergne, P Ordoukhanian, FE Romesberg. Site-specific labeling of DNA and RNA using an
efficiently replicated and transcribed class of unnatural base pairs. (2011) J Am Chem Soc, 133:19878-19888. 

	16.	 DA Malyshev, YJ Seo, P Ordoukhanian, FE Romesberg. PCR with an expanded genetic alphabet. (2009) J Am Chem Soc,
131:14620-14621. PMCID: 2978235. 

	17.	 I Hirao, M Kimoto, T Mitsui, T Fujiwara, R Kawai, A Sato, Y Harada, S Yokoyama. An unnatural hydrophobic base pair
system: site-specific incorporation of nucleotide analogs into DNA and RNA. (2006) Nat Methods, 3:729-735. 

	18.	 MF Goodman. Error-prone repair DNA polymerases in prokaryotes and eukaryotes. (2002) Annu Rev Biochem, 71:17-50. 

	19.	 J Samuelson. Bacterial Systems. In: AS Robinson, editor. Production of Membrane Proteins: Strategies for Expression
and Isolation: Wiley-VCH; 2011. p. 11-35. 

	20.	 MJ Giacalone, AM Gentile, BT Lovitt, NL Berkley, CW Gunderson, MW Surber. Toxic protein expression in Escherichia coli
using a rhamnose-based tightly regulated and tunable promoter system. (2006) Biotechniques, 40:355-364. 

	21.	 ST Cardona, CL Mueller, MA Valvano. Identification of essential operons with a rhamnose-inducible promoter in
Burkholderia cenocepacia. (2006) Appl Environ Microbiol, 72:2547-2555. PMCID: 1448982. 

	22.	 H Dong, W Tao, Y Zhang, Y Li. Development of an anhydrotetracycline-inducible gene expression system for
solvent-producing Clostridium acetobutylicum: A useful tool for strain engineering. (2012) Metab Eng, 14:59-67. 

	23.	 A Chatterjee, SB Sun, JL Furman, H Xiao, PG Schultz. A versatile platform for single- and multiple-unnatural amino
acid mutagenesis in Escherichia coli. (2013) Biochemistry, 52:1828-1837. PMCID: 3855549. 

	24.	 A Berlec, B Štrukelj. Current state and recent advances in biopharmaceutical production in Escherichia coli,
yeasts and mammalian cells. (2013) J Ind Microbiol Biotechnol, 40:257-274. 

	25.	 S Shao, RS Hegde. Membrane Protein Insertion at the Endoplasmic Reticulum. (2011) Annual Review of Cell and
Developmental Biology, 27:25-56. 

	26.	 A Idiris, H Tohda, H Kumagai, K Takegawa. Engineering of protein secretion in yeast: strategies and impact on protein
production. (2010) Appl Microbiol Biotechnol, 86:403-417. 

	27.	 P Malkus, F Jiang, R Schekman. Concentrative sorting of secretory cargo proteins into COPII-coated vesicles.
(2002) J Cell Biol, 159:915-921. PMCID: 2173974. 

	28.	 HB Parmar, C Barry, F Kai, R Duncan. Golgi complex-plasma membrane trafficking directed by an autonomous, tribasic
Golgi export signal. (2014) Mol Biol Cell, 25:866-878. PMCID: 3952855. 

	29.	 A Graf, M Dragosits, B Gasser, D Mattanovich. Yeast systems biotechnology for the production of heterologous proteins.
(2009) FEMS Yeast Res, 9:335-348. 

	30.	 M Delic, M Valli, AB Graf, M Pfeffer, D Mattanovich, B Gasser. The secretory pathway: exploring yeast diversity.
(2013) FEMS Microbiol Rev, 37:872-914. 

	31.	 C Da-Re, E Franzolin, A Biscontin, A Piazzesi, B Pacchioni, MC Gagliani, G
Mazzotta, C Tacchetti, MA Zordan, M Zeviani, P Bernardi, V Bianchi, C De Pitta, R Costa. Functional Characterization of drim2, the Drosophila melanogaster Homolog of the Yeast Mitochondrial Deoxynucleotide Transporter. (2014) J Biol Chem,
289:7448-7459. PMCID: 3953259. 

 EXHIBIT B 

BUDGET 
  

											
	 Principal Investigator/Program Director (Last, First, Middle):

 
	  	 Romesberg, Floyd
  
	 
	 
	 BUDGET

 
	  

	 	 	 
	
PERSONNEL (Applicant organization only)
	  	 %

 
	  	 	YEAR 1	 
	 NAME
	  	ROLE ON
PROJECT	  	 EFFORT  

ON  
 PROJ.  
	  	 
	        SALARY/
FRINGE	
 
	 Romesberg, Floyd
	  	
Principal
Investigator
  
	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	
Chin, Jodie
  
	  	 Research Scientist

 
	  	 [...***...]

 
	  	 	[...***...]	 
	 	 	 	 
	
Technician, TBN
  
	  	 Technician

 
	  	 [...***...]

 
	  	 	[...***...]	 
	
SUBTOTAL                

	  	 	[...***...]	 
	  EQUIPMENT 
(Itemize)
  
	  	 	 	 
	
 SUPPLIES  (Itemize by category)
	  	 	 	 
	
Bio/chemicals, molecular biology kits, enzymes, disposable plasticware (tubes, trays, pipette tips), bacterial and yeast growth media components

 
	  	 	[...***...]	 
	  TRAVEL

 
	  	 	 	 
	
 OTHER EXPENSES  (Itemize by category)
	  	 	 	 
	
DNA synthesis; DNA sequencing; Access fees for NMR and MS characterizations

 
	  	 	[...***...]	 
	 	 
	
 DIRECT COSTS
  
	  	$	[...***...]	 
	 	 
	
 INDIRECT COSTS @ [...***...]%

 
	  	$	[...***...]	 
	
 TOTAL COSTS  

 
  
	  	$	[...***...]	 

  
 ***Confidential
Treatment Requested 

 EXHIBIT C 

FORM OF MATERIAL TRANSFER AGREEMENT 
 THE
SCRIPPS RESEARCH INSTITUTE 
 MATERIAL TRANSFER AGREEMENT 

[Date] 
 [Contact’s Name] 

[Sponsor’s name] 
 [Sponsor’s Address] 

Dear Dr. [Contact’s Name]: 
 This is to
acknowledge your request for the [Materials Requested] to be provided by [Principal Investigator] at The Scripps Research Institute (TSRI) pursuant to Section 3.1.b of the Research Funding and Option Agreement between TSRI and [Sponsor’s
name] dated                                 . This material and all modifications
and derivatives of this material are referred to herein as “Materials”. 
 TSRI is pleased to cooperate with your use of these Materials at
[Sponsor’s name] for your scientific research. However, before forwarding them to you, TSRI needs [Sponsor’s name] to agree to the following terms and conditions: 

(1)    that TSRI hereby grants Sponsor a nonexclusive, royalty-free,
non-transferable license to make and use the Materials solely for your internal research purposes; 

(2)    that the Materials shall be received by [Sponsor’s name] only for use in scientific research in
[Sponsor’s name]’s laboratories and that all applicable guidelines set forth by the National Institutes of Health (NIH), U.S. Department of Agriculture (USDA) or other government agencies regarding the use of these Materials shall be
followed; 
 (3)    these Materials are provided as a service to the research community. THE MATERIALS ARE BEING
SUPPLIED TO YOU WITH NO WARRANTIES, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTY OF MERCHANTABILITY OF ANY KIND, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT OF THIRD PARTY RIGHTS
ARISING OUT OF COURSE OF CONDUCT OR TRADE CUSTOM OR USAGE, ALL OF WHICH ARE DISCLAIMED BY TSRI 

 (4)    that [Sponsor’s name] shall bear all risk to
[Sponsor’s name] and/or any others resulting from any use, directly or indirectly, to which [Sponsor’s name] puts the Materials or any other materials that could not have been made but for these Materials; 

(5)    that [Sponsor’s name] hereby defends, indemnifies, and holds harmless TSRI, its affiliates, its
trustees, officers, employees and agents from any loss, claim, damage, or liability, of any kind whatsoever, including without limitation reasonable attorney’s fees, expert witness fees and costs, whether or not a lawsuit or other proceeding is
filed, which may arise from [Sponsor’s name]’s use, storage or disposal of the Materials or any other material that could not have been made but for the Materials, except to the extent such arise due to the gross negligence or willful
misconduct of TSRI; 
 (6)    that you provide us with your Federal Express account number or an account number
for another courier service, so that we may ship the Materials to you. 
 The Materials are to be used with caution and prudence in any experimental
work, since all of their characteristics are not known. Moreover, they are not to be used for testing in or treatment of humans. 
 If you agree to
accept these Materials under the above conditions, please sign the enclosed duplicate copy of this letter, have it signed by an authorized representative of [Sponsor’s name] and return one original to me. Upon receipt of that confirmation I
will forward the Materials to you. 
 THE SCRIPPS RESEARCH INSTITUTE 

 

	
	
	 Scott Forrest

	 Senior Director, Technology Development

	 [Date]

 ACCEPTED: 
  

					
	 Recipient’s Signature
	 		    	 Authorized Institutional Rep. Signature

			
		 		    	
	 Recipient’s Printed Name and Title
	 		    	 Authorized Rep. Printed Name and Title

			
		 		    	
	 Date
	 		    	 Date

 FIRST AMENDMENT to 

RESEARCH FUNDING AND OPTION AGREEMENT 

This First Amendment (“Amendment”) is entered into effective as of the last date set forth below and is made to RESEARCH FUNDING AND
OPTION AGREEMENT dated July 31, 2014 (the “Agreement”) by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware corporation
(“Sponsor”). Capitalized terms used but not defined herein shall have the same meanings set forth in the Agreement. 

WHEREAS, the Parties desire to make certain amendments to the Agreement under the terms and conditions contained herein; 

NOW, THEREFORE, the Parties agree to amend the Agreement as follows: 

 

	1	 Sponsor and TSRI agree Section 2.4 (a) of the Agreement shall be revised to add the following payments
to the payment schedule: 

							
		 	 5th payment:
	 	due: [...***...]	  	amount (USD): $[...***...]
		 	 6th payment:
	 	due: [...***...]	  	amount (USD): $[...***...]
		 	 7th payment:
	 	due: [...***...]	  	amount (USD): $[...***...]
		 	 8th payment:
	 	due: [...***...]	  	amount (USD): $[...***...]

  

	2.	 Exhibit B-2 below shall be added to Exhibit B and is hereby
incorporated by reference. 

  

	3.	 Section 7.1 shall be deleted in its entirety and replaces as follows:  

Term.       Unless terminated sooner, the initial term of this Agreement
shallcommence on the Effective Date and shall continue until the earlier of (a) thesecond (2nd) anniversary of the Effective Date, and (b) the completion of theResearch Program, unless
extended by written mutual agreement of the parties. 
  

	4.	 The Research Program in Exhibit A of the Agreement shall be expanded by the research described in Exhibit A-1 below. 

 Except as expressly set forth herein, all of the terms and provisions of
the Agreement shall remain in full force and effect. 
 IN WITNESS WHEREOF, the Parties have executed this Amendment by their duly
authorized representatives as of the last date set forth below. 
  

									
	 TSRI:    
	 		 	Sponsor:                
	  
 THE SCRIPPS
RESEARCH INSTITUTE
	 		 	  
 SYNTHORX, INC.

			
		 		 	
	 By: /s/ Scott
Forrest                            
	 		 	By: /s/ Court
Turner                        
	             Scott
Forrest
	 		 	       Court Turner

			
	 Title: VP, Business Development
	 		 	Title: Chief Executive Officer
					
		 		 		 		 	
	 Date:
9/2/2015                                     
	 		 	Date:
9/2/2015                                

  
 ***Confidential
Treatment Requested 

 Exhibit A-1 

[...***...] 

  
 ***Confidential
Treatment Requested 

 Exhibit B-2 

Synthorx 
 Principal
Investigator/Program Director (Last, First, Middle): Romesberg, Floyd 

 
  

BUDGET 
  

									
	 	 	 
	
PERSONNEL (Applicant organization only)
	  	 %

 
 EFFORT

 
 ON

 
	  	 	YEAR 2	 
	  

NAME
	  	 ROLE ON

 
 PROJECT
	  	   

	
            SALARY/             

FRINGE
	   

 

	 	 	 	 
	 Romesberg,
Floyd
	  	Principal	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 Chin,
Jodie
	  	Research Scientist	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 Technician,
TBN
	  	Technician	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 
	
SUBTOTAL   

	  	 	[...***...]	 
		 
	 EQUIPMENT (Itemize)

 
	  	 	 	 
		 
	 SUPPLIES (itemize by category)

 
 Bio/chemicals, molecular biology kits, enzymes, disposable plasticware (tubes,
trays, pipette tips), bacterial and yeast growth media components
  
	  	 

	

[...***...]	

 
		 
	 TRAVEL

 
	  	 	 	 
		 
	 OTHER EXPENSES (itemize by category)

 
 DNA synthesis; DNA sequencing; access fees for NMR and MS characterizations

 
	  	 

	

[...***...]	

 
				 
	 TOTAL COSTS   

  
	  	 	  	 	  	$	              [...***...]	 

  
 ***Confidential
Treatment Requested 

 SECOND AMENDMENT to 

RESEARCH FUNDING AND OPTION AGREEMENT 

This Second Amendment (“Amendment”) is entered into effective as of the last date set forth below and is made to RESEARCH FUNDING AND
OPTION AGREEMENT dated July 31, 2014 (the “Agreement”) by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware
corporation(“Sponsor”). Capitalized terms used but not defined herein shall have the same meanings set forth in the Agreement. 

WHEREAS, the Parties desire to make certain amendments to the Agreement (as amended) under the terms and conditions contained herein; 

NOW, THEREFORE, the Parties agree to amend the Agreement as follows: 
  

	1.	 Sponsor and TSRI agree Section 2.4 (a) of the Agreement shall be revised to add the following payments
to the payment schedule: 

  

							
		 	 9th payment:
	 	 due: [...***...]
	  	amount (USD): $[...***...]
		 	 10th payment:
	 	 due: [...***...]
	  	amount (USD): $[...***...]
		 	 11th payment:
	 	 due: [...***...]
	  	amount (USD): $[...***...]
		 	 12th payment:
	 	 due: [...***...]
	  	amount (USD): $[...***...]

  

	2.	 Exhibit B-2 below shall be added to Exhibit B and is hereby
incorporated by reference. 

  

	3.	 Section 7.1 shall be deleted in its entirety and replaces as follows: 

Term. Unless terminated sooner, the initial term of this Agreement shall commence on the Effective Date
and shall continue until the earlier of (a) the third (3rd) anniversary of the Effective Date, and (b) the completion of the Research Program, unless extended by written mutual agreement
of the parties. 
  

	4.	 The Research Program in Exhibit A of the Agreement shall be expanded by theresearch described in Exhibit A-1 below. 

 Except as expressly set forth herein, all of the terms and provisions of
the Agreement shall remain in full force and effect. 
 IN WITNESS WHEREOF, the Parties have executed this Amendment by their duly authorized
representatives as of the last date set forth below. 
  

					
	 TSRI:
	 		  	 Sponsor.

			
	 THE SCRIPPS RESEARCH INSTITUTE
	 		  	 SYNTHORX, INC.

			
	 By: /s/ Julia
Roufer                                        
  
	 		  	 By: /s/ Court R.
Turner                                

		 		  	             Court R. Turner

	 Title:    Executive Director
	 		  	
	              Business Development
	 		  	 Title:  Chief Executive Officer

			
	
Date:    9/9/16                
                                    
	 		  	 Date:  
9/9/16                                        
       

  
 ***Confidential
Treatment Requested 

 Exhibit A-1 

[...***...] 

  
 ***Confidential
Treatment Requested 

 Exhibit B-2 

Synthorx 
 Principal
Investigator/Program Director (Last, First, Middle): Romesberg, Floyd 

 
  

BUDGET 
  

									
	 	 	 
	 PERSONNEL (Applicant organization only)
	  	 %

 
 EFFORT

 
 ON

 
	  	 	YEAR 2	 
	  

NAME
	  	  

ROLE ON
  

PROJECT
  
	  	 
 
	            SALARY/         
   
 FRINGE
	 

 

	
Romesberg, Floyd
	  	Principal	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 Chin,
Jodie
	  	Research Scientist	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 Technician,
TBN
	  	Technician	  	[...***...]	  	 	[...***...]	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 
	
SUBTOTAL  

	  	 	[...***...]	 
		 
	 EQUIPMENT (Itemize)

 
	  	 	 	 
		 
	 SUPPLIES (Itemize by category)

 
 Bio/chemicals, molecular biology kits, enzymes, disposable plasticware (tubes,
trays, pipette tips), bacterial and yeast growth media components
  
	  	 	[...***...]	 
		 
	 TRAVEL

 
	  	 	 	 
		 
	 OTHER EXPENSES (Itemize by category)

 
 DNA synthesis; DNA sequencing; access fees for NMR and MS
characterizations
  
  
	  	 	[...***...]	 
				 
	   TOTAL COSTS  

	  	 	  	 	  	 	$[...***...]	 

  
 ***Confidential
Treatment Requested 

 CONFIDENTIAL 
  

 THIRD AMENDMENT to 

RESEARCH FUNDING AND OPTION AGREEMENT 

This third Amendment (“Third Amendment”), entered into and made effective as of the last dated signature below, is made to RESEARCH
FUNDING AND OPTION AGREEMENT dated July 31st, 2014 (the “Agreement”) by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware corporation
(“Sponsor”). Capitalized terms used but not defined herein shall have the same meanings set forth in the Agreement. 
 WHEREAS,
the Parties desire to make certain amendments to the Agreement (as amended) under the terms and conditions contained herein; 
 NOW,
THEREFORE, the Parties agree to amend the Agreement as follows: 
  

	1	 Section 1.2 of the Agreement shall be deleted in its entirety and replaced as follows:

  

	 	1.2	 Agreement Number. The original Agreement has been assigned TSRI agreement number 2014-0475, the first
amendment has been assigned TSRI agreement number 2015-0949, the second amendment has been assigned TSRI agreement number 2016-0927, and this Third Amendment has been assigned TSRI agreement number 2017-0685. 

 

	2.	 In accordance with Exhibit B-1 and with the preceding amendments
referenced above, Section 2.4 (a) of the Agreement shall be revised to add the following payments to the payment schedule: 

  

							
		 	 13th payment:
	  	due: [...***...]	  	amount (USD): $[...***...]
		 	 14th payment:
	  	due: [...***...]	  	amount (USD): $[...***...]
		 	 15th payment:
	  	due: [...***...]	  	amount (USD): $[...***...]
		 	 16th payment:
	  	due: [...***...]	  	amount (USD): $[...***...]

  

	3.	 Exhibit B-2 below shall be added to Exhibit B and is hereby
incorporated by reference. 

  

	4.	 Section 7.1 shall be deleted in its entirety and replaced as follows: 

 

	 	7.1	 Term. Unless terminated sooner, the initial term of this Agreement shall commence on the Effective
Date and shall continue until the earlier of (a) the fourth (4th) anniversary of the Effective Date, and (b) the completion of the Research Program, unless extended by written mutual agreement of the parties. 

 

	5.	 The Research Program in Exhibit A of the Agreement shall be expanded by the research described in Exhibit A-1 below. 

 Except as expressly set forth herein, all of the terms and provisions of
the Agreement shall remain in full force and effect. 
 IN WITNESS WHEREOF, the Parties have executed this Third Amendment by their duly
authorized representatives as of the last date set forth below. 

  
 ***Confidential
Treatment Requested 
 Page 1 of 6 

 CONFIDENTIAL 
  

									
	 TSRI:
	 		 	Sponsor:                
			
	 THE SCRIPPS RESEARCH INSTITUTE
	 		 	SYNTHORX, INC.
			
	 By: /s/ Matt Tremblay
                                    
	 		 	By: /s/ Tighe
Reardon                                
	
                   
       Matt Tremblay
	 		 	
                      Tighe
Reardon

			
	 Title: VP, Business Development
	 		 	Title: Chief Financial Officer
		 		 		 		 	
	 Date: October 16, 2017
                                         
 
	 		 	Date: October 6, 2017
                                    

  
 Page 2 of 6 

 CONFIDENTIAL 
  

 Exhibit A-1 

[...***...] 

  
 ***Confidential
Treatment Requested 
 Page 3 of 6 

 CONFIDENTIAL 
  

 Exhibit B-1 

Synthorx 
 Principal
Investigator/Program Director (Last, First, Middle): Romesberg, Floyd 

 
  

BUDGET 
  

									
	 	 	 
	
PERSONNEL (Applicant organization only)
	  	 %

 
 EFFORT

 
 ON

 
	  	 	YEAR 2	 
	  

NAME
	  	 ROLE ON

 
 PROJECT
	  	   

	 SALARY/ 

FRINGE
	   

 

	
Romesberg, Floyd
	  	  

Principal
	  	[...***...]	  	 	[...***...]	 
	
Chin, Jodie
	  	  

Research Scientist
	  	[...***...]	  	 	[...***...]	 
	
Technician, TBN
	  	  

Technician
	  	[...***...]	  	 	[...***...]	 
	 	  	 	  	 	  	 	 	 
	 	  	 	  	 	  	 	 	 
	 	  	 	  	 	  	 	 	 
	 	  	 	  	 	  	 	 	 
	 	 
	
      SUBTOTAL   

	  	   
	 [...***...] 
	   

		 
	 EQUIPMENT (Itemize)

 
	  	 	 	 
		 
	 SUPPLIES (itemize by category)

 
 Bio/chemicals, molecular biology kits, enzymes, disposable plasticware
(tubes, trays, pipette tips), bacterial and yeast growth media components
	  	 

  
	

 [...***...] 
	

   

		 
	 TRAVEL

 
	  	 	 	 
	 	 
	 OTHER EXPENSES (itemize by category)

 
 DNA synthesis; DNA sequencing; access fees for NMR and MS characterizations

 
	  	 

	

[...***...]	

 
				 
	  DIRECT COSTS

 
	  	 	  	 	  	 	$        [...***...]	 
				 
	  INDIRECT COSTS @ [...***...] %

 
	  	 	  	 	  	 	$        [...***...]	 
				 
	  TOTAL COSTS  

  
	  	 	  	 	  	 	$        [...***...]	 

  
 ***Confidential
Treatment Requested 
 Page 6 of 6 

 FOURTH AMENDMENT 

to 
 RESEARCH FUNDING AND OPTION
AGREEMENT 
 This Fourth Amendment (“Fourth Amendment”), entered into and made effective as of the last dated signature below, is made to RESEARCH
FUNDING AND OPTION AGREEMENT dated July 31st, 2014 (the “Agreement”) by and between THE SCRIPPS RESEARCH INSTITUTE, a California nonprofit public benefit corporation (“TSRI”), and SYNTHORX, INC., a Delaware corporation
(“Sponsor”). Capitalized terms used but not defined herein shall have the same meanings set forth in the Agreement. 
 WHEREAS, the Parties desire
to make certain amendments to the Agreement (as amended) under the terms and conditions contained herein; 
 NOW, THEREFORE, the Parties agree to amend the
Agreement as follows: 
  

	1.	 Section 1.2 of the Agreement shall be deleted in its entirety and replaced as follows: 

 

	 	1.2	 Agreement Number. The original Agreement has been assigned TSRI agreement number 2014-0475, the first amendment
has been assigned TSRI agreement number 2015-0949, the second amendment has been assigned TSRI agreement number 2016-0927, the Third Amendment has been assigned TSRI agreement number 2017-0685, and this Fourth Amendment has been assigned TSRI
agreement number 2018-0769. 

  

	2.	 In accordance with Exhibit B-1 and with the preceding amendments
referenced above, Section 2.4 (a) of the Agreement shall be revised to add the following payments to the payment schedule: 

  

							
		 	 17th payment:
	  	 due: [...***...]
	  	 amount (USD): $[...***...]

				
		 	 18th payment:
	  	 due: [...***...]
	  	 amount (USD): $[...***...]

				
		 	 19th payment:
	  	 due: [...***...]
	  	 amount (USD): $[...***...]

				
		 	 20th payment:
	  	 due: [...***...]
	  	 amount (USD): $[...***...]

  

	3.	 Exhibit B-1 below shall be added to Exhibit B and is hereby
incorporated by reference. 

  

	4.	 Section 7.1 shall be deleted in its entirety and replaced as follows: 

 

	 	7.1	 Term. Unless terminated sooner, the initial term of this Agreement shall commence on the Effective Date and
shall continue until the earlier of (a) the fifth (5th) anniversary of the Effective Date, and (b) the completion of the Research Program, unless extended by written mutual agreement of the parties. 

 

	5.	 The Research Program in Exhibit A of the Agreement shall be expanded by the research described in Exhibit A-1 below. 

  
 ***Confidential
Treatment Requested 

 Except as expressly set forth herein, all of the terms and provisions of the Agreement shall remain in full
force and effect. 
 In WITNESS WHEREOF, the Parties have executed this Fourth Amendment by their duly authorized representatives as of the last date set
forth below. 
  

			
	 TSRI:
	  	 Sponsor:

	 THE SCRIPPS RESEARCH INSTITUTE
	  	 SYNTHORX, INC.

		
	 By: /s/ Daniel
Catron                                        
 
	  	 By: /s/ Laura Shawver,
Ph.D.            

		
	 Name: Daniel Catron
	  	 Name: Laura Shawver, Ph.D.            

		
	 Title: Director, Office of Technology Development
	  	 Title: Chief Executive Officer           

		
	 Date:
8/16/2018                                        
         
	  	 Date:
8/16/2018                                 

 Exhibit A-1 

[...***...] 

  
 ***Confidential
Treatment Requested 

 Exhibit B-1 

Synthorx 
 Principal
Investigator/Program Director (Last, First, Middle):         Romesberg, Floyd 
  
  

BUDGET 
  

							
	 	 	 
	  

PERSONNEL (Applicant organization only)
	  	 %

 
 EFFORT
ON
PROJ.
	 	YEAR 1
	
NAME
	  	  
 ROLE
ON
PROJECT
	 	
            SALARY/            

FRINGE

	 Romesberg, Floyd
	  	Principal
Investigator	  	[...***...]	 	[...***...]
	 Chin, Jodie

 
	  	Research Scientist	  	[...***...]	 	[...***...]
	 Technician, TBN

 
	  	Technician	  	[...***...]	 	[...***...]
	  

SUBTOTAL  

  
	 	[...***...]
	  EQUIPMENT (Itemize)

 
	 	 
	
 SUPPLIES (Itemize by category)
	 	 
	
Bio/chemicals, molecular biology kits, enzymes, disposable plasticware (tubes, trays, pipette tips), bacterial and yeast growth media components

 
	 	[...***...]
	  TRAVEL

 
	 	 
	
 OTHER EXPENSES (Itemize by category)
	 	 
	
DNA synthesis, DNA sequencing, access fees for NMR and MS characterizations

 
	 	[...***...]
	  

 DIRECT COSTS
  
	 	$            
[...***...]
	  

 INDIRECT COSTS @ [...***...] %

 
	 	$           
 [...***...]
	  

 TOTAL COSTS  

  
	 	$           
 [...***...]

  
 ***Confidential Treatment
Requested

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00289-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00289-of-00352.parquet"}]]