Document:

AGEN-Exhibit 10.4.1 Q1 14

20th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 11/01/2010

BioCentiv [logo]

20th Addendum
to Lease Agreement No. 01/2003
from 12/01/2002

BioCentiv GmbH        (Lessor)
and             4-Antibody AG        (Lessee)

amend the above-mentioned Lease Agreement on the basis of the application of BioCentiv GmbH to the State Administration Office of Thuringia from 09/08/2010 (Annex 1 to this Addendum) and its approval from 10/05/2010 (Annex 2 to this Addendum) as follows:

Section 3 Term of lease, termination

The lease term is extended by three years until 02/28/2014.

The Lessee is granted the option of extending the lease for another two years. The Lessee must decide about exercising this option at least nine months before the expiry of the lease (05/31/2013).

A termination notice period of 12 months is agreed upon for the term of the lease.

The Lessor has the right to terminate the lease according to the contract, especially when other small and medium-sized companies express the need to use spaces in the BioInstrumentezentrum, and such need cannot be fulfilled otherwise. Such need must be demonstrated to the Lessee.

Section 4 Rent, other payments

The basis for the calculation of the rent starting from 03/01/2011 is the expert opinion of the Expert Office of Roland Fehler, Bad Langensalza, from 07/02/2008 (Annex 3 to this Agreement).

    

    

[initials]

Page 1 of 2

20th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 11/01/2010

BioCentiv [logo]

Therefore, the following rent is payable starting March 2011:

	
				
	Subtotal rent, net
	

	€7,742.81
	

	Center’s flat charge
	

	€739.55
	

	Prepaid incidental expenses
	

	€4,000.00
	

	Total rent, net
	

	€12,482.36
	

	19% VAT
	

	€2,371.65
	

	Total rent, gross
	

	€14,854.01
	

Jena, 11/01/2010

	
			
	BioCentiv GmbH
	4-Antibody AG
Germany Branch

	[signature]
Dr. Klaus Ullrich
Director
	[signature]
Dr. Ulf Grawunder
Authorized Agent
	[signature]
Dr. Eva-Maria Stegemann
Authorized Agent

Page 2 of 2

innocad

Leased Properties in the Period (03/01/2011–02/28/2014)

Debtor/Lessee:        18 / 4-Antibody AG        Contract Type:    Standard Agreement
Contract No.:        01/2003
Contract Term:        03/01/2003–02/28/2014        Status:        active

	
															
	Leased Property
	Area
	Type of Use
	Price per m2
	Rent
	Flat Charge
	Prepaid Operating Costs

	 
	0.00 m2
	 
	

	€0.00
	

	

	€0.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space SP 06 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space SP 08 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space SP 09 – Outdoor Parking Space
	1.00 m2
	 
	

	€30.00
	

	

	€30.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 03 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 04 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 10 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 13 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 37 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 41 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 47 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 48 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Open Space TG1 49 – Underground Parking Space
	1.00 m2
	 
	

	€40.00
	

	

	€40.00
	

	

	€0.00
	

	

	€0.00
	

	Room 1.201
	26.26 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€210.08
	

	

	€39.39
	

	

	€0.00
	

	Room 1.202
	26.57 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€212.56
	

	

	€39.86
	

	

	€2,000.00
	

	Room 1.203
	47.54 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€808.18
	

	

	€71.31
	

	

	€400.00
	

	Room 1.204
	49.35 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€838.95
	

	

	€74.03
	

	

	€600.00
	

	Room 1.205
	48.93 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€831.81
	

	

	€73.40
	

	

	€600.00
	

	Room 1.206
	49.70 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€844.90
	

	

	€74.55
	

	

	€0.00
	

	Room 1.207
	51.77 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€880.09
	

	

	€77.66
	

	

	€0.00
	

	Room 1.208
	42.66 m2
	3.3. Technological Lab
	

	€15.50
	

	

	€661.23
	

	

	€63.99
	

	

	€0.00
	

	Room 1.209
	6.31 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€31.55
	

	

	€9.47
	

	

	€0.00
	

	Room 2.301
	26.20 m2
	2.1 Office Spaces
	

	€8.00
	

	

	€209.60
	

	

	€39.30
	

	

	€0.00
	

	Room 2.303
	49.07 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€834.19
	

	

	€73.61
	

	

	€400.00
	

	Room 2.305
	48.86 m2
	3.3. Technological Lab
	

	€17.00
	

	

	€830.62
	

	

	€73.29
	

	

	€0.00
	

	Room 2.309
	6.31 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€31.55
	

	

	€9.47
	

	

	€0.00
	

	Room M1.014.4
	7.90 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€39.50
	

	

	€11.85
	

	

	€0.00
	

	Room M1.014.5
	5.60 m2
	4.1 Storage spaces
	

	€5.00
	

	

	€28.00
	

	

	€8.40
	

	

	€0.00
	

[initials]
	
			
	Monday, 11/01/2010
	Innocad®
	Page 1 of 2AGEN-Exhibit 10.4.2 Q1 14

28th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 07/02/2013

BioCentiv [logo]

28th Addendum
to Lease Agreement No. 01/2003
from 12/01/2002

BioCentiv GmbH        (Lessor)
and             4-Antibody AG        (Lessee)

amend the above-mentioned Lease Agreement on the basis of the approval of the State Administration Office of Thuringia per e-mail from 06/07/2013 (copy in Annex 1 to this Addendum) as follows:

Section 3 Term of lease, termination

The lease term is extended until 06/30/2016.

The Lessee is granted the option of extending the lease for another two years on the same conditions. The Lessee must decide about exercising this option at least nine months before the expiry of the lease (09/30/2015).

All other provisions of the Lease Agreement remain in effect.

Jena, 07/02/2013

	
			
	BioCentiv GmbH
	4-Antibody AG
Germany Branch

	[signature]
Dr. Klaus Ullrich
Director
	[signature]
Dr. Robert Burns
Director
	[signature]
Dr. Luis Martin-Parras
Authorized Agent

[handwritten:] Enclosure
 

Page 1 of 1
Message                                        Page 1 of 1

Klaus Ullrich

From:        TLVwA Korn, Daniel [Daniel.Korn@tlvwa.thueringen.de]
Sent:        06/07/2013 07:21 AM
To:        Klaus Ullrich
Cc:        TLVwA Sindermann, Bärbel
Subject:    4-Antibody AG Lease

Granting investment grants from the funding of the joint task “Improvement of Regional Economic Structure” (GRW [Joint Task Regional Economic Structure])

Project:        Construction of Bioinstrumentezentrum, 1st BA
Project number:    28163461

Dear Dr. Ullrich,

In a letter from 05/30/2013 you informed us that 4-Antibody AG expressed the wish to extend the lease till 06/30/2016.

The extension is approved if the company is still a KMU [small or medium-sized company] at the time of extension, continues to pay a competitive rent, and there are no other small and medium-sized companies that need to use the spaces.

If you have any questions, please do not hesitate to contact us.

Kind regards,

Daniel Korn
Administrator

________________________________________________

THÜRINGER LANDESVERWALTUNGSAMT [STATE ADMINISTRATION OFFICE OF THURINGIA]
Referat [Department] 500 | Infrastrukturförderung [Infrastructure Development]
Weimarplatz 4 | 99423 Weimar | PO Box 2249 | 99403 Weimar
Tel.: +49 (361) 3773-7481 | Fax: +49 (361) 3773-9464
www.thueringen.de Ù Daniel.Korn@tlvwa.thueringen.de

06/07/2013
BioCentiv [logo]

BioCentiv GmbH Ù Winzerlaer Strasse 2 Ù 07745 Jena

Thüringer Landesverwaltungsamt 
Ms. Sindermann
Weimarplatz 4

99423 Weimar
05/03/2013

4-Antibody AG Lease at BioInstrumentezentrum
Your letter from 10/05/2010

Dear Ms. Sindermann:

4-Antibody AG has exercised its option right from the approved lease and, at the same time, expressed the wish to extend no only till 02/28/2016, but at once till 06/30/2016.

Since the underlying conditions for extension did not change at all in 2010, from my perspective, I support the application of 4-Antibody AG to extend the lease till 06/30/2016 on the same conditions that you informed us of in your letter from 05/10/2010.
We sent you the respective lease agreement on 12/30/2010.

If you have any objections to this action, I kindly ask you to inform us of this by 06/07/2013. Otherwise, I will proceed as described above.

Kind regards,

BioCentiv GmbH

[signature]
Dr. Klaus Ullrich
Director

	
		
	 
	BioCentiv GmbH
Winzerlaer Strasse 2
07745 Jena
Tel. +49 3641 508600
Fax +49 3641 508610
E-mail mail@biocentiv.com
Website www.biocentiv.com

Chairperson of the Supervisory Board
Prof. Dr. A. Tünnermann

Director
Dr. K. Ullrich

Sparkasse Jena-Saale-Holzland
BRN 830 530 30
Account 2 224
IBAN
DE45 8305 3030 0000 0022 24
BIC HELA DE F1 JEN

Commercial Reg. No. 207546, District Court of Jena
Tax ID No. 161/106/08733
VAT ID No. DE198475335
Tax ID No. 162/106/03011AGEN-Exhibit 10.4.3 Q1 14

29th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 08/09/2013

BioCentiv [logo]

29th Addendum
to Lease Agreement No. 01/2003
from 12/01/2002

BioCentiv GmbH        (Lessor)
and             4-Antibody AG        (Lessee)

amend the above-mentioned Lease Agreement per 09/01/2013 as follows:

Section 4 Rent, other payments

(1) b    The prepaid incidental expenses from September to December 2013 are set to €7,959.93.

The prepaid incidental expenses starting January 2014 are set to €6,279.98.

Starting 09/01/2013–12/31/2013, the total monthly rent is as follows:

	
				
	Subtotal rent, net
	

	€8,891.11
	

	Center’s flat charge, net
	

	€859.20
	

	Prepaid incidental expenses
	

	€7,959.93
	

	Total rent, net
	

	€17,710.24
	

	19% VAT
	

	€3,364.95
	

	Total rent, gross
	

	€21,075.19
	

Starting 01/01/2014, the total monthly rent is as follows:

	
				
	Subtotal rent, net
	

	€8,891.11
	

	Center’s flat charge, net
	

	€859.20
	

	Prepaid incidental expenses
	

	€6,279.98
	

	Total rent, net
	

	€16,030.29
	

	19% VAT
	

	€3,045.76
	

	Total rent, gross
	

	€19,076.05
	

Page 1 of 2

29th Addendum to the BioCentiv – 4-Antibody Lease Agreement from 08/09/2013

BioCentiv [logo]

All other provisions of the Lease Agreement remain in effect.

Jena, 08/09/2013

	
			
	BioCentiv GmbH
	4-Antibody AG
Germany Branch

	[signature]
Dr. Klaus Ullrich
Director
	[signature]
Dr. Robert Burns
Director
	[signature]
Dr. Luis Martin-Parras
Authorized Agent

Page 2 of 2

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