Document:

<PAGE>

                                                                    Exhibit 10.9

      [LOGO]                                MORTON G. THALHIMER, INC. Realtors
MORTON G. THALHIMER                             Industrial Lease Agreement
                                                   1313 East Main Street
                                                 Richmond, Virginia 23219
                                                      (804) 648-5881

THIS LEASE AGREEMENT, entered into this 24th day of February, 1998, by and
between Thomas S. Gilman thereinafter referred to as "Landlord" or first party,
and Discovery Therapeutics, Inc. a Delaware corporation hereinafter referred to
as "Tenant" or second party, and Morton G. Thalhimer, Inc., Agent, hereinafter
referred to as "Agent".

                               W I T N E S S E T H

For and in consideration of the below stated rent and other terms and conditions
stipulated in this Lease Agreement, hereinafter referred to as the "Lease",
Landlord does hereby lease to Tenant, and Tenant does hereby rent from Landlord,
the following described lot, piece or parcel of land, together with all
improvements thereon (the said land and improvements thereon hereinafter
referred to as the "Leased Premises") to-wit:

2028 Dabney Road, identified by Henrico County tax map as parcel Number
95-A2-046-E-17, containing Approximately 4,050 square feet

TO HAVE AND TO HOLD said land and improvements thereon and the privileges and
appurtenances thereunto belonging unto the Tenant, its permitted successors and
asaigns, for the term hereinafter provided, and upon all of the following terms
and conditions, to which the parties mutually covenant and agree:

1.       TERM:

         The original term of this lease shall be for one (1) year(s) and shall
commence on the 1st day of May, 1998 (The "Commencement Date"), and shall end on
the 30th day of April, 1999 (The "Expiration Date").

2.       POSSESSION:

         If the Landlord shall be unable to give possession on The Commencement
Date of the term hereof by reason of the holding over of any tenant or tenants
or for any cause beyond the control of the Landlord (other than extra work
undertaken by the Landlord for the Tenant), then the rent shall not commence
until possession of the Leased Premises is given or is available, and the Tenant
agrees such allowance and abatement of rent, as liquidated damages, in full
satisfaction for the failure of the Landlord to give possession of the Leased
Premises on the said date, and in the exclusion of all claims and rights which
the Tenant might otherwise have by reason of possession of the entire Leased
Premises not being given on the said date. If Landlord is unable to give
possession due to extra work undertaken at Tenant's request then the rent shall
commence as scheduled without abatement or allowance. If Landlord is otherwise
unable to give possession on The Commencement Date, then The Expiration Date
shall be extended from the actual date of occupancy in accordance with the lease
term specified in this Lease.

         If Tenant shall occupy the Leased Premises prior to The Commencement
Date of this Lease with Landlord's consent, all the provisions of this Lease
shall be in full force and effect as soon as Tenant occupies the Leased Premises
and The Expiration Date shall not change.

3.       RENT:

         During the original term of this Lease, Tenant covenants to pay a base
annual rental to Landlord of Thirty Five Thousand One Hundred Eighty Four
Dollars ($35,184.00), payable in equal monthly installments in advance on the
first day of each month in the amount of Two Thousand Nine Hundred Thirty Two
Dollars ($2,932.00). An additional rental may be required by attaching hereto an
addendum executed by all parties to this Lease Agreement.

         If the original term does not commence on the first day of the month,
Tenant shall pay, on The Commencement Date, for the period from The Commencement
Date to the first day of the following calendar month a sum equal to
one-thirtieth of the monthly rental due hereunder for each day of such period.
All rents thereafter shall be payable in advance on the first day of each month.
All rents due Landlord shall be paid when due to Morton O. Thalhimer, Inc., P.O.
Box 702, Richmond, Virginia 23218-0702, or to such other place as Landlord may
designate in writing to Tenant. If any installment of rent or any additional
rent is not paid within seven (7) days of the due date, in addition to all other
remedies of Landlord, the delinquent rent or additional rent shall be subject to
a charge of ten percent (10%) as liquidated damages.

         All monetary obligations of Tenant to Landlord under the terms of this
Lease shall be deemed to be rent.

4.       RENT ESCALATION:

         Beginning on the first twelve (12) month anniversary of The
Commencement Date of the Lease and on each succeeding anniversary date hereafter
for the term of the Lease and any renewals or extensions thereof, the rental
rate for the Leased Premises shall increase 4% per annum over the rate charged
for the immediately preceding twelve (12) months.

5.       SECURITY DEPOSIT:

         Tenant has deposited with Landlord, Two Thousand Five Hundred Thirty
One and Twenty Five Cents Dollars ($2,531.25) as security for the faithful
performance by Tenant of its commitments contained herein. Landlord may retain
the security deposit as liquidated damages of Tenant: (1) vacates leaving unpaid
rent or charges owed to the Landlord, or (2) leaves the Leased Premises unclean
or damaged beyond the limits of normal wear and tear. The provisions of this
paragraph shall not limit the amount of any claim by Landlord against Tenant
under any other terms or provisions of this Lease.

6.       TAXES AND ASSESSMENTS:

         Tenant agrees that as additional rental for the Leased Premises, it
will, during each calendar year of the original and all renewal terms, reimburse
Landlord for such part of the cost of all real estate taxes, charges or
assessments levied or assessed during the original and all renewal terms upon
and against the Leased Premises in excess of the cost of such taxes and
assessmentscharged or assessed upon or against the Leased Premises for the year
Year for Taxes and Assessment; provided however, that for the first and final
calendar years of the original or renewal terms Tenant shall be liable for the
reimbursement of such excess cost only for the proportionate part of such years
that it is in possession of the Leased Premises. The amount of such additional
rents, if any, shall be due and payable thirty (30) days after notification from
Landlord or its agent of the amount due.

7.       USE OF LEASED PREMISES:

         Tenant shall use the Leased Premises solely for pharmaceutical research
and development and in strict accordance with all applicable laws, ordinances
and regulations of governmental authorities. Tenant shall use the Leased
Premises for no other purpose without prior written consent of the Landlord.
Tenant will not use or permit or suffer the use of the Leased Premises for any
unlawful or offensive business or purpose. Tenant will not, without the prior
written consent of Landlord, use or permit the walls, fences, roof or any other
part of the Leased Premises to be used for advertising purposes.

<PAGE>

         (8) Conduct expeditiously, to the reasonable satisfaction of Lessor,
and in accordance with any applicable Environmental Law any response action
necessary to remove, remediate, clean up, or abate any Release, threatened
Release, or disposal of a Hazardous Material at Lessee's expense to the extent
such Response Action is attributable to events or conditions which arose on or
after the Lease commencement date;

         (9) Upon the written request of the Lessor, timely provide, at Lessee's
expense, a Phase 1 environmental site assessment of reasonable scope, form, and
depth by a consultant reasonably approved by Lessor as to (a) any matter to the
extent such matter arisen during the Lease term and (i) for which notice to
Lessor is required to be provided pursuant to the requirements of this Addendum
or (ii) which may reasonably be believed by Lessee to form the basis of an
Environmental Claim in connection with the Premises. If such a requested
environmental report is not delivered within forty-five (45) days reasonable
cost of which shall be payable by Lessee on demand and shall be treated as
additional rent under the Lease;

         (10) allow Lessor and its representatives from time to time, at
Lessor's reasonable discretion and expense, to inspect the Premises and conduct
an environmental assessment, including, without limitation, to facilitate the
sale or leasing of the Premises;

         (11) promptly provide or otherwise make available to Lessor any
reasonably requested Environmental Record concerning the Premises which Lessee
possesses or can reasonably obtain;

         (12) remove from the Premises, at Lessee's sole expense, by the Lease
termination date any Hazardous Materials or equipment to manufacture, generate,
transport, treat, store, Release, dispose, or handle any Hazardous Material used
by Lessee or in the course of Lessee's business; and

         (13) upon vacating the Premises, Lessee shall either (a) certify to
Lessor in writing that the Premises are in compliance with any applicable
Environmental Law, there has been during the term no Release on or in the
Premises, and the Premises are free of all Hazardous Material or (b) Lessee
shall deliver to Lessor within thirty (30) days of the Lease termination date a
phase 1 environmental site assessment of reasonable scope, form and depth by a
consultant reasonably approved by Lessor.

         C.       Indemnification and Waivers. Lessee shall indemnify, defend,
hold harmless, and hereby waives any claims for contribution against, Lessor for
any Damages (excluding Damages caused by Lessor and his agents and events or
conditions existing prior to the Lease commencement date) to the extent they
arise from:

         (a) events or conditions which existed on or after the Lease
commencement date and relate to:

                  (i) any Release, threatened Release, or disposal of any
Hazardous Material at the Premises;

                  (ii) the operation or violation of any Environmental Law at
the Premises; or,

                  (iii) any Environmental Claim in connection with Premises; or

         (b) the inaccuracy or breach of any representation or warranty by
Lessee in this Addendum or the Lease.

         D.       Defined Terms. Except as set forth below, defined terms used
in this Addendum shal have the meaning ascribed to them in the Lease. The terms
set forth below shall have the following meaning:

                                        2

<PAGE>

      [LOGO]                                                 1313 E. Main Street
MORTON G. THALHIMER                                           Richmond, VA 23214
                                                              Phone 804.648.5881
                                                                Fax 804.697.3479

                                AGENCY DISCLOSURE

Virginia law and regulations require real estate agents to disclose their agency
relationships to all prospective customers and clients. In addition to meeting
that requirement, this disclosure is intended to inform customers about agency
relationships and the duties of real estate agents, brokers and firms. For
convenience, Morton G. Thalhimer, Inc., and all other real estate agents,
brokers and firms are hereinafter collectively referral to as "licensees" since
they are all required to be licensed by the Virginia Real Estate Board.

Agency is the relationship formed when one person works for or represent another
person by express authority. People whom licensees represent are called clients.
People who receive services from licensees without being represented by the
licensees are called customers. A licensee does not necessarily represent the
person who pays him or her. As a result, a licensee can represent the buyer, but
be paid by the seller, or vice versa. Although agency relationships can be
formed without a written agreement, you should not assume that any person
represents you unless you have a written agreement with such person. The
agreement between the licensee and the client creates a brokerage relationship.

Client Status. As a client, you enter into an agreement with a licensee for that
licensee to represent you. This agreement may be called a "listing," a
"managemant agreement," a "buyer broker agreement," or an "agency agreement,"
depending on whether you are a seller, landlord, buyer, or tenant. You are then
the licensee's client. If the agreement is an exclusive agreement, you are
required to work through that licensee. The licensee will generally be entitled
to a commission if you buy, sell, or lease (as appropriate) property, even if
you do not use the services of the licensee. The licensee is required to give
you advice as to price and other matters and to disclose any material
information known to the licensee about the property or the transaction. The
licensee will also help you to negogiate favorable terms. The licensee is also
required not to disclose to other parties any personal of financial information
about you or any other information you ask to be kept confidential.

Customer Status. As a customer, you do not sign an agreement with a licensee
(although the licensee is still required to obtain this Agency Disclosure Form
executed by you). You are then the licensee's customer. The licensee may
represent the other party in the transaction, who will be the licensee's client.
You are not legally required to work through the licensee, and the licensee will
only be entitled to a commission if you buy, sell or lease (as appropriate)
property through the licensee. The licensee can give you general advice and is
required to treat you honestly and disclose material facts known to the licensee
regarding the physical condition of the property, but the licensee generally
cannot give advice regarding price or assistance in negotiating favorable terms.
The licensee is required to disclose to its client any information which it
knows about you which might be helpful to the client. If you will be a customer,
you should be aware that there may be other relevant information concerning the
transaction which may be obtained from other sources.

Additional Duties of Licensees. In addition to the duties that are described
above and any duties included in the agreement between the licensee and the
client, a licensee has certain duties under the Virginia law and the Virginia
Real Estate Board regulations. A licensee must promote the interests of its
client by seeking a buyer or tenant or an appropriate property for its clients,
although a licensee is not required to continue these efforts after a contract
has been signed, and by timely presenting all written offers and counter-offers.
A licensee must account to its clients for all money and property which the
licensees receives in which the client has an interest. Before a licensee enters
into a brokerage relationship, the licensee must advise the prospective client
of the type of relationship which is proposed, the licensee's compensation and
whether the licensee will share that compensation with a licensee who represents
another party to the transaction. A licensee owes its clients a duty of ordinary
cure.

Dual Agency. Dual Agency, or Dual Representation, is the situation which exists
when the same licensee represents both the buyer and the seller or the landlord
and the tenant. This generally occurs where a buyer or a tenant which is a
client of a licensee becomes interested in a property which is listed with the
same real estate company. This leads to conflicts of interest, which Virginia
law permits licenses to handle in two different ways. The first alternative is
Simple Dual Agency. With this alternative, the broker and all salespersons
continue to represent both parties, but they do not share any confidential
information. The other alternative involves the use of Designated
Representatives. With this alternative, the broker is still a dual agent, but
separate agents are named to represent the buyer and the seller or the landlord
and the tenant, and these agents represent their respective clients as if the
agents work for separate companies. Both agents must give their best advice and
keep the confidences of their clients. Licensees are required by law to disclose
to both parties whenever a dual agency relationship arises and any time
designated representatives are used, and all parties must then sign a Disclosure
of Dual Repreentation or Disclosure of Use of Designated Representatives form.

Firm Policies. Morton G. Thalhimer, Inc., represents both buyers and sellers and
landlords and tenants. In cases of dual agency, Morton G. Thalhimer, Inc., uses
designated representatives whenever possible. When representing sellers,
landlords, and optionors, Morton G. Thalhimer, Inc., has a policy of cooperating
with both licensees who work with the other party as customers and licensees who
work with the other party as clients unless otherwise instructed by the Firm's
client. When working with buyers, either as customers or clients, the policy of
Morton G. Thalhimer, Inc., is to show properties listed with Morton G.
Thalhimer, Inc., and other real estate firms.

             This is not an agreement, but only a disclosure form.

                      DISCLOSURE OF BROKERAGE RELATIONSHIP

I acknowledge that Morton G. Thalhimer, Inc., and Gregg W. Beck and James Bell
(Name of Salesperson) have disclosed to me that they represent the following
party in this real estate transaction: Landlord

The commission for the transaction contemplated between the undersigned will be
paid by: Landlord

Property: 2028 Dabney Road, Henrico VA

<TABLE>
<S>      <C>                 <C>                    <C>
3/3/98   Thomas S. Gilman    /s/ Thomas S. Gilman   Discovery Therapeutics, Inc.
-------  ------------------  ---------------------  ----------------------------
Date     Printed Name        Signature              Company

         James V. Peck       /s/ James V. Peck
_______  ------------------  ---------------------
Date     Printed Name        Signature
</TABLE>

<PAGE>

                          ADDENDUM TO INDUSTRIAL LEASE

     This Addendum to Industrial Lease made this ____ day of __________, 1994
("Addendum") is attached to, made a part of and supersedes all inconsistent
provisions of that certain Industrial Lease of even date herewith (the "Lease")
among Thomas S. Gilman, as Lessor, and Discovery Therapeutics, Inc., a Delaware
corporation, as Lessee.

         A.       Representations and Warranties of Lessee. Lessee represents
and warrants on the date hereof and throughout the term of the Lease that:

         (1)      Lessee shall comply with any applicable Environmental Law;

         (2)      Lessee shall obtain all Governmental Approvals required for
its intended operations at the Premises by any applicable Environmental Law; and

         (3)      Lessee shall use no material quantity of any Hazardous
Material and conduct no Hazardous Material Activity at the Property, except as
set forth on Schedule A attached hereto.

         B.       Covenants and Rights of Lessee. Lessee shall:

         (1)      maintain the Property in compliance in all respects with any
applicable Environmental Law and be responsible for making any notification or
report concerning the Premises to any Governmental Authority required to be made
by any applicable Environmental Law;

         (2)      not assign or sublease any portion of the Premises, except on
terms and conditions concerning environmental, health, and safety matters which
are satisfactory to Lessor, in Lessor's sole discretion;

         (3)      obtain and maintain in full force and effect all material
Governmental Approvals required by any applicable Environmental Law for
operations at the Premises;

         (4)      expeditiously sure, to the reasonable satisfaction of Lessor,
any violation of applicable Environmental Laws at the Premises at the expense of
Lessee to the extent such violation is attributable to events or conditions
which arose on or after the Lease commencement date;

         (5)      not create or operate at the Premises any hazardous waste
management facility or solid waste disposal facility as defined pursuant to RCRA
or any comparable state law;

         (6)      without the prior written consent of Lessor, not manufacture,
use, generate, transport, treat, store, Release, dispose, or handle any
Hazardous Material at the Premises except as set forth on Schedule A attached
hereto;

         (7)      within two (2) business days, notify Lessor in writing of and
provide any reasonably requested documents upon learning of any of the following
which arise in connection with the Premises;

                  (a)      any liability for response or corrective action,
natural resource damage, or other harm pursuant to CERCLA, RCRA, or any
comparable state law;

                  (b)      any Environmental Claim;

                  (c)      any violation of an Environmental Law or Release,
threatened +
Release, or disposal of a Hazardous Material;

                  (d)      any restriction on the ownership, occupancy, use, or
transferability arising pursuant to any (i) Release, threatened Release, or
disposal of a Hazardous Substance or (ii) Environmental Law; or

                  (e)      any environmental, natural resource, health, or
safety condition which could materially impair the condition of the Premises or
could have a Material Adverse Effect.

<PAGE>

15.      RENEWAL:

         It is hereby understood and agreed that a written notice of three (3)
months prior to the end of said term or any renewal or continuance thereof from
either party to the other shall be necessary to terminate this Lease as the end
of said term, or at the end of any renewal or continuance thereof, and in the
event that not such notice shall be given, then this Lease shall be continued in
full force and effect from year to year at the rent then in force and subject to
all the covenants, terms and conditions herein contained including this
paragraph and any rental escalation provisions contained in this Lease.

16.      HOLDING OVER:

         Tenant shall pay to Landlord an amount as base monthly rental equal to
200% of the base monthly rental herein provided during each month of portion
thereof for which Tenant shall retain possession of the Leased Premises or any
part thereof after the expiration of the term or of Tenant's right of
possession, whether by lapse of time or otherwise, and also shall pay all
damages sustained by Landlord, whether direct or consequential, on account
thereof. Such hold over shall be as a tenant at will and all of the terms and
provisions of this Lease shall be applicable during such period. No holding over
by Tenant, whether with or without consent of Landlord, shall operate to extend
this Lease except as may be herein provided. The provisions of this clause shall
not be held as a waiver by Landlord of any right of re-entry, or any other right
of Landlord as provided under this Lease; nor shall the receipt of said payment
or any part thereof, or any other act in apparent affirmance of tenancy, operate
as a waiver of the right to forfeit this Lease and the Term hereby granted for
the period still unexpired, for any breach of any of the covenants herein or any
other of Landlord's rights hereunder.

17.      INSPECTION BY LANDLORD:

         Tenant shall permit Landlord, its agents, or employees to inspect the
Leased Premises and all parts thereof during business hours and to enforce and
carry out any provision of this Lease Agreement and for the further purpose of
showing the Leased Premises to prospective tenants and purchasers and
representatives of lending institutions. During the last three (3) months of the
original term and all renewals of extensions thereof, Landlord shall have the
right to place "For Rent" signs in conspicuous places on the Leased Premises and
to otherwise advertise the Leased Premises for rent, in addition to having the
rights of entry and inspection set forth herein.

18.      DEFAULT BY TENANT:

         The happening of any of the following enumerated events shall
constitute a default for which Landlord, in addition to other right or remedies
it may have, shall have the immediate right of re-entry without service of
notice or resort to legal process and without Landlord being guilty of trespass,
or becoming liable for any loss or damage which may by occasioned thereby. (a)
failure of Tenant to pay any rent due hereunder within ten (10) days after
written notice to Tenant of such failure; (b) vacation of the Leased Premises by
Tenant or advertising by Tenant in any manner that would indicate or lead the
public to believe that Tenant was going out of business or intending to vacate
the Leased Premises; (c) the filing by, on behalf of or against Tenant, of any
petition or pleading to declare Tenant insolvent or unable to pay its debts or
meet its obligations under the laws of the United States or any state; or a
receiver of the property of Tenant is appointed; or the levy of execution or
other taking of property, assets or the leasehold interest of Tenant by process
of law or otherwise in satisfaction of any judgment, debt or claim against
Tenant; or (d) failure of Tenant to perform any of the other terms, conditions
or covenants of this Lease agreement for more than ten (10) days after written
notice of such failure shall have been given to Tenant.

         Should Landlord elect to re-enter and terminate Tenant's use of the
Leased Premises as herein provided, or should Landlord take possession pursuant
to legal proceedings or pursuant to any provisions under law, Landlord may
either terminate this Lease or it may from time to time without terminating this
Lease, make such alterations and repairs as may be necessary in order to relet
the Leased Premises, and relet the Leased Premises or any part thereof for such
term or terms (which may be for a term extending beyond the original or renewal
terms of this Lease) and at such rent and upon such other terms and conditions
as Landlord, in its sole discretion may deem advisable. Upon each such reletting
all rent received by Landlord from such reletting shall be applied, first, to
the payment of any indebtedness other than rent due hereunder from Tenant to
Landlord; second, to the payment of any costs and expenses for such repossession
and reletting, including brokerage fees and attorney's fees and costs of
alterations and/or repairs, third, to the payment of rent due and unpaid
hereunder, and the residue, if any, shall be held by Landlord and applied in
payment of future rent as the same may become due and payable hereunder. If the
Leased Premises are not relet as aforesaid, or if the rent received for such
reletting during any month be less than that to be paid during the month by
Tenant to Landlord hereunder, Tenant shall promptly pay the rental due hereunder
or any such deficiency as the case may be to Landlord. Such deficiency shall be
calculated and paid monthly. No such re-entry or taking possession of the Leased
Premises by Landlord shall be construed as an election on its part to terminate
this Lease unless a written notice of such election be given to Tenant or unless
the termination he decreed by a court of competent jurisdiction. Notwithstanding
any such reletting without termination, Landlord may at any time thereafter
elect to terminate this Lease for such previous breach. Tenant will pay Landlord
and Agent respectively all expenditures incurred by them in enforcing the
provisions of this Lease including reasonable fees of attorneys and others
employed by Landlord of Agent.

         Except as expressly herein provided to the contrary, any amount due to
Landlord not paid when due shall bear simple interest at twelve percent (12%)
per annum.

         All of this foregoing remedies shall be in addition to any other rights
Landlord may have at law or in equity, and waiver of one default shall not be
deemed to be a waiver of any subsequent default.

19.      SUBORDINATION OF LEASE:

         This Lease is made, and accepted by the Tenant, subject to subordinate
in law and in equity to any existing, future and/or new mortgages, and/or deeds
of trust secured by the land and building of which the Leased Premises are a
part, or which may at any future time be placed thereon, and to any extensions,
modifications and renewals thereof, and to the prior right of the mortgagees or
lenders thereunder. If required by the Landlord, the Tenant will execute,
acknowledge and deliver any and all agreements subordinating this Lease to any
deed of trust or mortgage now thereafter executed, secured by the said land and
said buildings. Within ten (10) days after request therefore by Landlord, Tenant
agrees to deliver in recordable form a certificate prepared by Landlord to any
proposed mortgages or purchaser of the Leased Premises or to Landlord certifying
(if such is the case) that this Lease is in full force and effect, and that
there are no defenses or offsets thereto, or stating those claimed by Tenant,
and such other facts related to this Lease, the Leased Premises or Tenant as
Landlord may request. If Tenant does not execute and return such certificates as
required above. Tenant hereby irrevocably appoints Landlord as its
attorney-in-fact to execute such certificate on behalf of Tenant.

20.      HAZARDOUS SUBSTANCE:

         Hazardous substance issues are covered in the attached Addendum.

         LIMITATION OF LANDLORD'S OBLIGATION:

         Landlord shall have no liability in Tenant by reason of any
inconvenience, annoyance or injury to business arising from Landlord, other
Tenants or others in their activities, making repairs, alterations, additions or
improvements in or to a portion of the building or the Leased Premises, to
fixtures, appurtenances, or equipment thereof, and no liability upon Landlord
for failure of Landlord or others to make any repairs, alterations, additions or
improvements in or to a portion of the building or the Leased Premises, or the
building's fixtures, appurtenances, or equipment thereof. As a material part of
the considerations to Landlord. Tenant further assumes all risk of damage to
property or injury to persons of about the Leased Premises arising from any
cause, and Tenant hereby waives all claims in respect thereof against Landlord
and Agent, except any claim arising out of Landlord's gross negligence or
willful misconduct.

         AGENT'S COMPENSATION:

         In consideration of Agent's services in procuring this Lease and as a
covenant running with the land upon which the Leased Premises is located,
Landlord covenants with, and for the benefit of, Agent, as follows: Agent shall
receive a commission of six percent (6%) of the rent

<PAGE>

8.       CONDITION OF LEASED PREMISES:

         Tenant has examined and is satisfied with the present condition of the
Leased Premises and the equipment thereon, if any. No representation has been
made to Tenant, or Tenant's agents, by Landlord, or Landlord's agents,
concerning the condition of the Leased Premises (and the equipment thereon, if
any) or any particular use that can be made thereof. Neither Landlord nor Agent
shall be under any duty to instruct Tenant or others as to the use of any
equipment on the Leased Premises. Tenant acknowledges that the Leased Premises
are suitable for the proposed business use including being in compliance with
all ordinances, regulations, zoning and municipal or State law as relates to
Tenant's intended use of the Leased Premises.

9.       ASSIGNMENT, SUBLETTING AND MORTGAGING:

         Tenant shall not assign this Lease or sublet the Leased Premises, in
whole or in part, without Landlord's prior written consent. If consent to assign
or sublease is obtained, no such assignment or sublease shall in any way release
or relieve Tenant or Guarantor from any of its covenants or undertakings
contained in this Lease Agreement, and in all cases under this paragraph, Tenant
and Guarantor shall remain liable on this Lease during the original and all
renewal terms. Tenant's request for consent to any subletting or assignment of
this Lease shall be accompanied by a written statement setting forth the details
of the proposed sublease or assignment and any other information Landlord deems
relevant. Landlord shall have the right to (a) withhold consent, if reasonable;
(b) grant consent; or; (c) terminate this Lease as of the effective date of such
sublease or assignment, in which case Landlord may elect to enter into a direct
lease with the proposed assignee or subtenant. Tenant shall be liable for
reasonable fees incurred by the Landlord in connection with an assignment,
subletting or mortgage of the Leased Premises.

10.      UTILITIES

         During the term of this Lease, Tenant shall promptly pay all fuel,
water, gas, electricity, sewerage, telephone and other utility bills, as the
same become due, it being understood and agreed that the Tenant shall promptly
make all required deposits for meters and utilities service. Landlord shall not
be liable for any interruption or failure in the supply of any utility to the
Leased Premises.

11.      INSURANCE AND INDEMNITY:

         Tenant will indemnify and save harmless Landlord and Agent from any and
all liability, damage, loss, expense, cause of action, suits, claims, of
judgments arising from injury to person or property including, without
limitation, environmental liabilities on the Leased Premises, or upon the
adjoining sidewalks, or otherwise resulting from the use of the Leased Premises.
Tenant covenants that it will keep in force at is own expense at all times
during the original and all renewal terms of this Lease in companies and in form
acceptable to Landlord with respect to the Leased Premises insurance covering
Landlord and Tenant and Agent as named insureds with combined minimum limits of
One Million Dollars ($1,000,000.00) per occurrence, and Tenant shall deliver to
Landlord or Agent a certificate of insurance showing the same to be in force and
effect.

         If Tenant shall not comply with its covenant to maintain insurance as
provided herein, Landlord may, at its option, cause insurance as aforesaid to be
issued, and, in such event, Tenant shall promptly pay when due the premiums for
such insurance as additional rent hereunder.

         Tenant will pay, as additional rent hereunder, all excess insurance
premiums (i.e., premiums in excess of the usual premiums for a non-hazardous
risk) required to be paid by Landlord on any buildings on the Leased Premises by
reason of Tenant's use or occupancy thereof within thirty(30) days from
notification from Landlord or its Agent of the amount due.

12.      PERSONAL PROPERTY:

         In addition to all other remedies provided by law, Landlord shall have
a lien against all personal property on the Leased Premises, and insurance
proceeds, if any collected therefore, as security for the payment of the rent
and default in obligations hereunder. Tenant shall repair or reimburse Landlord
for the cost of repairing any damages to the Leased Premises resulting from the
installation or removal of personal property of Tenant.

13.      REPAIRS AND ALTERATIONS:

         Tenant shall, at is expense, during the term of this Lease, keep the
Leased Premises in good order and condition, and perform all repairs and
maintenance that become necessary in or about the Leased Premises including,
without limitation, plumbing and electrical systems and procuring and
maintaining service contracts for the heating and/or air conditioning systems.
Tenant shall not make any alterations of, additions to, or changes in, the
Leased Premises or equipment without the prior written consent of Landlord,
which consent shall not be unreasonably withheld, and all alterations, changes,
and improvements by whomsoever made, shall be the property of Landlord. Nothing
contained in this paragraph shall be construed as requiring Landlord to make any
repairs except repairs of a structural nature. Landlord shall maintain and make
all necessary structural repair to the foundations, load bearing walls, and
roofs.

         Tenant shall comply with all applicable laws and regulations of
governmental authorities with respect to the use of the Leased Premises and to
any work, except repairs of a structural nature, which may be ordered by such
governmental authorities; but if Tenant, after notice ordering the work, fails
to comply with reasonable promptness, Landlord, without notice to Tenant, may do
such work and collect the cost thereof from Tenant as additional rent hereunder.
If Landlord is required to abate any nuisance on the Leased Premises. Landlord
may do so without notice to Tenant and Tenant shall pay all costs thereof as
additional rent hereunder within thirty(30) days from notification from Landlord
or its Agent of the amount due.

         Tenant shall, on the last day of the original or renewal term, or upon
the sooner termination of this Lease, peaceably and quietly surrender the Leased
Premises and equipment to Landlord, broom-clean, including all improvements,
alterations, rebuildings, replacements, changes or additions placed by Tenant
thereon, in as good condition and repair as the same were in at the commencement
of the original term, normal wear and tear accepted.

14.      DESTRUCTION OF LEASED PREMISES, CONDEMNATION:

         If all or any portion of the Leased Premises are damaged or destroyed
by fire or other casualty covered by insurance, or condemned by public
authority, whether by eminent domain or otherwise, notwithstanding any Virginia
law to the contrary, then (1) if totally destroyed or condemned so that the
Leased Premises are rendered untenantable, this Lease shall terminate as of the
date of such destruction or condemnation, and Tenant shall, be liable for the
rent only to the date of such destruction or condemnation, and the entire amount
of insurance proceeds and/or condemnation award for the Leased Premises shall
belong to and be payable to Landlord; or (2) if only partially destroyed or
condemned and still tenantable, Landlord shall, within a reasonable time, repair
the Leased Premises with a reasonable reduction of rent from the date of such
partial destruction or condemnation until there be again premises substantially
similar in value to Tenant as the Leased Premises partially destroyed or
condemned. Landlord's obligation to repair or restore the Leased Premises as
stated herein is conditioned upon (a) all insurance proceeds and/or condemnation
award for the Leased Premises being paid to Landlord, which are sufficient to
cover the cost of said repairs and restorations, and (b) there remaining at
least twenty-four (24) months in the then existing term of this Lease. If
Landlord does not repair the Leased Premises because either conditions (a) or
(b) are not met, Landlord shall so notify Tenant and this Lease shall terminate
as of the date of such partial destruction or condemnation and Tenant shall be
liable for rent only to the date of such partial destruction or condemnation. As
used herein, the date of condemnation shall be the date on which legal title
vests in the condemning authority or the date on which Landlord enters into a
contract for the sale for public use upon the threat of condemnation, whichever
first occurs.

         If the improvements shall be damaged or destroyed by any hazard not
covered by insurance, Landlord shall have the option to cancel this lease by
giving written notice of such cancellation to Tenant within thirty(30) days
after the happening of such damage or destruction, but if such option not be
exercised, then Landlord at is own expense shall proceed with due diligence to
repair or restore the improvements to their condition as existed before such
damage or destruction with rent being reduced pro rata in proportion to the
decrease in usefulness of the Leased Premises undergoing repair and restoration;
provided, however, that the cost of repairing any damage or destruction not
covered by insurance which is caused by tenant's fault or negligence shall
forthwith be paid to Landlord by Tenant.

         Tenant shall give immediate written notice to Landlord or Agent of any
damage, destruction or condemnation of the Leased Premises, whether in total or
partial.

<PAGE>

                             FIRST ADDENDUM TO LEASE

THIS FIRST ADDENDUM TO LEASE dated January 7, 1999 amends a certain lease dated
February 24, 1998 for an office/warehouse space at 2028 Dabney Road, between
Discovery Therapeutics, Inc. (herein Discovery), Tenant and Thomas S. Gilman,
Landlord.

IT IS COVENANTED and agreed to as follows:

1.       The lease for the above referenced property shall be extended until
         August 31, 1999 at the current monthly rate and terms.

2.       Discovery agrees to lease the adjacent suite, currently leased to
         Vallen Safety Supply Company (herein Vallen) at 2028 Dabney Road,
         effective March 1, 1999 through August 31, 1999 at a monthly rate of
         $1,496.000 through the term. All the terms and rules of the current
         lease shall apply to the tenancy in the Vallen space. This lease
         extension and lease of additional space is subject to the execution of
         a mutual release between Vallen and Gilman nullifying their current
         lease.

3.       It is understood that Discovery plans to create an opening between the
         spaces to connect the areas. Discovery will gain the approval of the
         design for the opening prior to the commencement of this work or any
         other future alterations. If Discovery fails to extend the lease beyond
         8/31/99, then they will be responsible for restoring the demising wall
         to it's origanal condition.

4.       Discovery may begin to utilize the Vallen space to stage move in and
         the installation of communications equipment beginning on or about
         February 1, 1999 as Vallen has agreed. Discovery agrees to indemnify
         and hold Gilman and Vallen harmless for any activity in the Vallen
         space prior to March 1, 1999 and name Thomas S. Gilman as additional
         insured on their liability policy for this additional risk prior to
         entering the Vallen space.

         IN WITNESS WHEREOF, this Addendum has been executed by the parties
         hereto pursuant to valid authority as of the below dates.

         LESSOR: /s/ Thomas S. Gilman     Date: 1-18-1999
                 -----------------------
                 Thomas S. Gilman

         LESSEE: DISCOVERY THERAPEUTICS, INC.
                  a Delaware corporation

                 By: /s/ James V. Peck
                     ----------------------

                     Its: V.P., OPERATIONS (Title)

<PAGE>

                            SECOND ADDENDUM TO LEASE

THIS SECOND ADDENDUM TO LEASE dated July 14th, 1999 amends a certain lease dated
February 24, 1998 for an office/warehouse space at 2028 Dabney Road, between
Discovery Therapeutics, Inc. (herein Discovery), Tenant and Thomas S. Gilman,
Lanlord.

IT IS COVENANTED and agreed to as follows:

1.       The lease for the above referenced property (both the original lease
         space and the "Vallen" space) shall be extended until August 31, 2001.
         This monthly rent shall remain at its current level of $4,428.00 until
         August 31, 2000 and will increase to $4,605.00 per month from September
         1, 2000 through August 31, 2001.

2.       Paragraph 13 of the lease shall be amended as follows: The tenant shall
         be responsible for any HVAC repair per occurrence of up to $500.00,
         Landlord shall pay any amount over $500.00 per occurrence.

3.       All other terms and conditions shall remain unchanged.

         IN WITNESS WHEREOF, this Addendum has been executed by the parties
         hereto pursuant to valid authority as of the below dates.

         LESSOR:  /s/ Thomas S. Gilman           Date: 7/29/99
                 -----------------------
                 Thomas S. Gilman

         LESSEE: DISCOVERY THERAPEUTICS, INC.
                  a Delaware corporation

                 By: /s/ James V. Peck
                     ---------------------
                     Its: V.P. OPERATIONS (Title)

4.       The base year with respect to taxes and assessments for paragraph 3 of
         the lease shall be 1998.

<PAGE>

                             THIRD ADDENDUM TO LEASE

THIS THIRD ADDENDUM TO LEASE dated September 12th, 2000 amends a certain lease
dated February 24, 1998 for an office/warehouse space at 2028 Dabney Road,
between Discovery Therapeutics, Inc. (herein Discovery), Tenant and Thomas S.
Gilman, Landlord.

IT IS COVENANTED and agreed to as follows:

         1.       The Landlord agrees to have installed and pay for the cost of
                  the improvements depicted on Exhibit "A" attached. And further
                  described on Schedule "A", which is the bid and scope of work
                  prepared by Calfee & Douglas, Inc.

         2.       The term of the above mentioned Lease as was amended in the
                  Second Addendum, shall be further amended as follows: The
                  Lease shall be extended for a three year term commencing
                  December 1, 2000 until November 30, 2003. The rent for the
                  initial 12 month term shall be $5,851.00 and shall escalate as
                  provided in the lease.

         3.       Tenant shall have the right to cancel the lease at any time
                  during the three year extension by giving the Agent written
                  notice 90 days before the cancellation date. In the event
                  Tenant cancels the lease, Tenant shall pay a cancellation fee
                  of three months of the current rent and the remaining
                  additional rent for the improvements being made by Landlord
                  (i.e., $1,246.00/month multiplied by the number of months
                  remaining of the three year term).

All other terms and conditions shall remain unchanged.

         IN WITNESS WHEREOF, this Addendum has been executed by the parties
         hereto pursuant to valid authority as of the below dates.

         LESSOR: /s/ Thomas S. Gilman     Date:  9/21/00
                 -----------------------
                 Thomas S. Gilman

         LESSEE: DISCOVERY THERAPEUTICS, INC.
                  a Delaware corporation

                 By: /s/ James V. Peck
                     -----------------

                    Its: V.P., OPERATIONS (Title)

<PAGE>

                                  EXHIBIT "A"

                            OFFICE PLAN APPEARS HERE

                                  Lab & office

                                    Expansion

                                 Scale 1/8" = 1"

                              FRONT EXISTING OFFICE

                                 *Sink roughins

<PAGE>

                                  SCHEDULE "A"

                             CALFEE & DOUGLAS, INC.
                               General Contractor

                            2107-C N. Hamilton Street

                            Richmond, Virginia 23230

                                 (804) 359-9031

                               (804) 359-9033 fax

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------
                                UNITS    UNIT              TOTAL     $/SF   HEADING
           ITEM                 REQ'D    COST   UNITS       COST     COST    TOTALS
-----------------------------------------------------------------------------------
<S>                             <C>    <C>      <C>       <C>        <C>    <C>
HVAC: (Allowance)                                                           $ 2,975
          Rework Existing           1  2975.00    LS      2,975.00   2.58

PLumbing: (Allowance)                                                       $ 5,700
          Sink Rough In             2   625.00    EA      1,250.00   1.09
          HW Heater                 1   750.00    EA        750.00   0.65
          ADA Shower                1  3500.00    EA      3,500.00   3.04
          ADA Access                1   200.00    EA        200.00   0.17

Doors / Hardware: (Allowance)                                               $ 4,830
          Blding Standard           8   525.00    EA      4,200.00   3.66
          Hardware                  8    50.00    EA        400.00   0.35
          Bifolds                   2   115.00    EA        230.00   0.20

Wallcovering: (Allowance)                                                   $ 2,251
          Partitions (Flat)      4554     0.29    SF      1,320.66   1.15
          Stain Doors              10    65.00    EA        650.00   0.56
          Jambs                     8    35.00    EA        280.00   0.24
-----------------------------------------------------------------------------------
                                                  SUBTOTAL                  $31,508
                                             8%   General Conditions          2,521
                                            10%   Overhead & Profit           3,403
===================================================================================
                                                  TOTAL                     $37,432
</TABLE>

NOTES:

This price is for budget purposes only.

No asbestos testing or removal included.

Please note where allowances were used.

Prices does not include low voltage wiring, permit or demo.

No work on warehouse side of new partitions.

Sinks supplied & installed by others.

Price does not include removing warehouse equipment or supplies.

C&D assume HVAC & electrical system is sufficient.<PAGE>

                                                                   Exhibit 10.10

                              EMPLOYMENT AGREEMENT

         THIS EMPLOYMENT AGREEMENT ("Agreement") is made and entered into as of
January 2, 2002 (the "Effective Date"), by and between ADERIS PHARMACEUTICALS,
INC., a Delaware corporation (the "Company"), and Peter G. Savas ("Executive").

AGREEMENT

1.       EMPLOYMENT

         The Company hereby employs Executive and Executive hereby accepts
employment upon the terms and conditions set forth below.

2.       TERM AND RENEWAL

         2.1      Term. The term of this Agreement shall commence on the
Effective Date, and shall continue for two (2) years from the Effective Date
(the "Original Employment Term"), on the terms and conditions set forth below,
unless sooner terminated as provided in Section 5.

         2.2      Extension. Following the expiration of the Original Employment
Term and provided that this Agreement has not been terminated pursuant to
Section 5, and every year thereafter, the Agreement shall be automatically
renewed for an additional 12 month period (the "Extension Period"), effective on
each anniversary date of the Effective Date, unless either party notifies the
other party in writing not less than 30 days prior to the expiration of the
Original Employment Term or any subsequent 12 month period.

3.       COMPENSATION

         3.1      Base Compensation. For the services to be rendered by
Executive under this Agreement, Executive shall be entitled to receive an
initial annual base compensation ("Base Compensation") of $350,000, payable in
substantially equal bi-weekly installments. Thereafter, the Base Compensation
shall be reviewed and adjusted annually as recommended by the Compensation
Committee (the "Compensation Committee") and approved by the Board of Directors
(the "Board") of the Company, or if there is no Compensation Committee, then by
the Board; provided, however, in no event may the Base Compensation be adjusted
below the initial annual Base Compensation set forth in this Section 3.1.

         3.2      Bonus Compensation. The Compensation Committee shall review
Executive's performance at least annually during each year of the Original
Employment Term and during any periods of automatic extension of this Agreement
pursuant to Section 2.2. The Compensation Committee shall recommend and the
Board shall approve and authorize the Company to award Executive a cash bonus
which shall reasonably be determined as fairly compensating and rewarding
Executive for services rendered to the Company and/or as an incentive for
continued service to the Company. The amount of such cash bonus shall be
determined in the sole and absolute discretion of the Board based upon the
recommendation of the Compensation Committee, shall be dependent on, among other
things, the achievement of certain performance levels by the Company, including,
growth in funds from operations, and Executive's performance and contribution to
increasing the funds from operations.

<PAGE>

         3.3      Benefits.

                  (a)      Medical Insurance. The Company shall provide to
Executive and Executive's spouse and children, at its sole cost, such health,
dental and optical insurance as the Company may from time to time make available
to its other executive employees.

                  (b)      Life and Disability Insurance. The Company shall
provide Executive such disability and life insurance as the Company in its sole
discretion may from time to time make available to its other executive
employees.

                  (c)      Pension Plans, Etc. Executive shall be entitled to
participate in all pension, 401(k) and other employee plans and benefits
established by the Company on at least the same terms as the Company's other
executive employees.

         3.4      Vacation. Executive shall be entitled to four (4) vacation
weeks (20 business days) in each calendar year, subject to and on a basis
consistent with Company policy. In addition, Executive shall be entitled to all
Company holidays.

4.       POSITION AND DUTIES

         4.1      Position. Unless otherwise mutually agreed during the Term of
this Agreement, Executive shall serve as President and Chief Executive Officer.
The Company agrees that the duties that may be assigned Executive shall be the
usual and customary duties of the offices of President & Chief Executive
Officer. Executive shall have such executive power and authority as shall
reasonably be required to enable Executive to discharge the duties of such
offices. At the Company's request, Executive may, at Executive's discretion,
serve the Company and its respective subsidiaries in other offices and
capacities in addition to the foregoing, but shall not be required to do so. In
the event the Company and Executive mutually agree that Executive shall
terminate Executive's service in any one or more of the aforementioned
capacities, or Executive's service in one or more of the aforementioned
capacities is terminated, Executive's compensation, as specified in this
Agreement, shall not be diminished or reduced in any manner.

         4.2      Devotion of Time and Effort. Executive shall use Executive's
good faith best efforts and judgment in performing Executive's duties as
required hereunder and to act in the best interests of the Company. Executive
shall devote substantially all of his business time and attention to the
performance of services of the Company in his capacity as an officer thereof and
as may reasonably be requested by the Board.

         4.3      Other Activities. Executive may engage in other activities for
Executive's own account while employed hereunder, including, charitable,
community and other business activities, provided that such other activities do
not materially interfere with the performance of Executive's duties hereunder.

         4.4      Business Expenses. The Company shall promptly, but in no event
later than ten days after submission of a claim of expenditure, reimburse
Executive for all reasonable business expenses including, business seminar fees,
professional association dues and reasonable entertainment expenses incurred by
Executive in connection with the business of the Company, upon presentation to
the Company of written receipts for such expenses. Such reimbursement shall also
include, but not be limited to, reimbursement for all reasonable travel
expenses,

                                        2

<PAGE>

including all airfare, hotel and rental car expenses incurred by Executive in
travelling in connection with the business of the Company.

         4.5      Company's Obligations. The Company shall provide Executive
with any and all necessary or appropriate current financial information and
access to current information and records regarding all material transactions
involving the Company, including but not limited to acquisition of assets,
personnel contracts, dispositions of assets, service agreements and registration
statements or other state or federal filings or disclosures, reasonably
necessary for Executive to carry out Executive's duties and responsibilities
hereunder. In addition, the Company agrees to provide Executive, as a condition
to Executive's services hereunder, such staff, equipment and office space as is
reasonably necessary for Executive to perform Executive's duties hereunder.

5.       TERMINATION

         5.1      By Company Without Cause. The Company may terminate this
Agreement without "cause" (as hereinafter defined) at any time following the
Effective Date, provided that the Company first deliver to Executive the
Company's written election to terminate this Agreement at least 90 days prior to
the effective date of termination.

         5.2      Severance Payment.

                  (a)      Amount. In the event the Company terminates
Executive's services hereunder without cause pursuant to Section 5.1 or by
Executive pursuant to Section 5.4 or 5.6, Executive shall continue to render
services to the Company pursuant to this Agreement until the date of termination
and shall continue to receive compensation, as provided hereunder, through the
termination date. In addition to other compensation payable to Executive for
services rendered through the termination date, the Company shall pay Executive
no later than the date of such termination, as a single severance payment, an
amount equal to (i) Executive's highest monthly Base Compensation paid hereunder
during the preceding 12 month period, multiplied by the greater of the number of
months remaining in the employment term (as determined under Section 2 above)
measured from the termination date or 12, plus (ii) one times the average annual
bonus received by the Executive during the preceding twenty-four month period
(the "Severance Amount").

                  (b)      Benefits. In the event Executive's employment
hereunder is terminated by the Company without cause pursuant to Section 5.1, by
the Company with cause on account of Executive's Disability (as defined in
Section 5.3(d) hereof), or by Executive pursuant to Section 5.4 or 5.6, then in
addition to paying Executive the Severance Amount, the Company shall continue to
provide to Executive and Executive's spouse and children, as applicable, all of
the benefits described in Section 3.3 for a period equal to the greater of (i)
the remaining term of this Agreement or (ii) one year commencing on the date of
such termination (the "Severance Benefits").

                  (c)      Acceleration of Vesting.

                           (i)      In the event Executive's employment
hereunder is terminated by the Company without cause pursuant to Section 5.1, or
by Executive pursuant to Section 5.4 or 5.6, then in addition to paying
Executive the Severance Amount and the Severance Benefits, the

                                        3

<PAGE>

vesting of (A) the unvested portion of any stock option to purchase Company
common stock granted to Executive ("Stock Options") and (B) any shares of
Company common stock granted to Executive which is subject to forfeiture
("Restricted Stock"), shall continue to vest for a period of (1) one year and,
with respect to the vested portion of any Restricted Stock, shall cease to be
subject to forfeiture and, with respect to the vested portion of any Stock
Options, shall be exercisable.

                           (ii)     In the event Executive's employment
hereunder is terminated on account of Executive's death, the vesting of (A) the
unvested portion of any stock option to purchase Company common stock granted to
Executive ("Stock Options") and (B) any shares of Company common stock granted
to Executive which is subject to forfeiture ("Restricted Stock"), shall continue
to vest for a period of (1) one year and, with respect to the vested portion of
any Restricted Stock, shall cease to be subject to forfeiture and, with respect
to the vested portion of any Stock Options, shall be exercisable.

         5.3      By the Company For Cause. The Company may terminate Executive
for cause at any time, upon written notice to Executive. For purposes of this
Agreement, "cause" shall mean:

                  (a)      Executive's conviction for commission of a felony;

                  (b)      Executive's willful commission of any act of theft,
embezzlement or misappropriation against the Company;

                  (c)      Executive's willful and continued failure to
substantially perform Executive's duties hereunder (other than such failure
resulting from Executive's incapacity due to physical or mental illness), which
failure is not remedied within a reasonable time after written demand for
substantial performance is delivered by the Company which specifically
identifies the manner in which the Company believes that Executive has not
substantially performed Executive's duties; or

                  (d)      Executive's death or Disability (as hereinafter
defined).

         In the event Executive is terminated for cause pursuant to this Section
5.3, Executive shall have the right to receive Executive's compensation as
otherwise provided under this Agreement through the effective date of
termination. Executive shall have no further right to receive compensation or
other consideration from the Company or have any other remedy whatsoever against
the Company as a result of this Agreement or the termination of Executive
pursuant to this Section 5.3, except as set forth below with respect to a
termination due to Executive's Disability.

         In the event Executive is terminated by reason of Executive's
Disability (but not death), the Company shall immediately pay Executive a single
severance payment equal to the Severance Amount. Said payment shall be in
addition to any disability insurance payments to which Executive is otherwise
entitled and any other compensation earned by Executive hereunder. For purposes
of this Agreement, the term "Disability" shall mean a physical or mental
incapacity as a result of which Executive becomes unable to continue the proper
performance of Executive's duties hereunder for six consecutive calendar months
or for shorter periods aggregating 180 business days in any 12 month period, but
only to the extent that such definition does not violate the Americans with
Disabilities Act of 1990.

                                        4

<PAGE>

         5.4      By Executive For Good Reason. Executive may terminate this
Agreement for good reason upon at least 30 days' prior written notice to the
Company. For purposes of this Agreement, "good reason" shall mean:

                  (a)      the Company's material breach of any of its
respective obligations hereunder and either such breach is incurable or, if
curable, has not been cured within 30 business days following receipt by the
Company of written notice from Executive to the Company of such breach by the
Company;

                  (b)      any material decrease in Executive's title,
authority, or responsibilities as an officer of the Company without Executive's
prior written consent; or

                  (c)      any decrease in the Base Compensation including any
adjustments under Section 3.1 above or Benefits under Section 3.3 above payable
to Executive by the Company without Executive's prior consent; any decrease in
the Bonus Compensation under Section 3.2 above shall not constitute good reason;
or

         In the event that Executive terminates this Agreement for good reason
pursuant to this Section 5.4, Executive shall have the right to receive
Executive's compensation as provided hereunder through the effective date of
termination and shall also have the same rights and remedies against the Company
as Executive would have had if the Company had terminated Executive's employment
without cause pursuant to Section 5.1 (including the right to receive the
Severance Amount payable and the Severance Benefits to be provided under Section
5.2).

         5.5      Executive's Voluntary Termination. Executive may, at any time,
terminate this Agreement without good reason upon written notice delivered to
the Company at least 90 days prior to the effective date of termination. In the
event of such voluntary termination of this Agreement by Executive: (i)
Executive shall have the right to receive Executive's compensation as provided
hereunder through the effective date of termination; and (ii) the Company on the
one hand, and Executive, on the other hand, shall not have any further right or
remedy against one another except as provided in Sections 6, 7 and 8 hereof
which shall remain in full force and effect.

         5.6      Change of Control. Executive may terminate this Agreement,
upon at least 30 days' prior written notice to the Company at any time within
one year after a "change in control" (as hereinafter defined) of the Company. In
the event Executive terminates this Agreement within one year after a change in
control pursuant to this Section 5.6, (i) Executive shall continue to render
services pursuant hereto and shall continue to receive compensation, as provided
hereunder, through the termination date, (ii) the Company shall pay Executive no
later than the date of such termination, as a single severance payment, an
amount equal to the Severance Amount and (iii) following such termination, the
Company shall provide the Severance Benefits as required by Section 5.2(b). For
purposes of this Agreement, a "change in control" shall mean the occurrence of
any of the following events:

                  (a)      an acquisition of any voting securities of the
Company (the "Voting Securities") by any "person" (as the term "person" is used
for purposes of Section 13(d) or Section 14(d) of the Securities Exchange Act of
1934, as amended (the "1934 Act")) immediately after which such person has
"beneficial ownership" (within the meaning of Rule

                                        5

<PAGE>

13d-3 promulgated under the 1934 Act) of 50% or more of the combined voting
power of the Company's then outstanding Voting Securities; or

                  (b)      approval by the stockholders of the Company of:

                           (i)      a merger, consolidation, share exchange or
reorganization of the Company, unless the stockholders of the Company,
immediately before such merger, consolidation, share exchange or reorganization,
own, directly or indirectly immediately following such merger, consolidation,
share exchange or reorganization, at least 60% of the combined voting power of
the outstanding voting securities of the corporation that is the successor in
such merger, consolidation, share exchange or reorganization (the "Surviving
Company") in substantially the same proportion as their ownership of the Voting
Securities immediately before such merger, consolidation, share exchange or
reorganization; or

                           (ii)     a complete liquidation or dissolution of the
Company; or

                           (iii)    an agreement for the sale or other
disposition of all or substantially all of the assets of the Company.

6.       NON-SOLICITATION

         During the period following the date Executive's employment hereunder
is terminated where the Executive continues to receive Compensation, Severance,
Benefits or Vesting under this Agreement, Executive shall not solicit or induce
any of the Company's employees, agents or independent contractors to end their
relationship with the Company, or recruit, hire or otherwise induce any such
person to perform services for Executive.

7.       NON-COMPETITION AfTER TERMINATION

         Executive agrees to be bound by the terms of the Confidential
Information and Non-Competition agreement attached hereto as Exhibit A and
incorporated herein by reference.

8.       INDEMNIFICATION

         To the fullest extent permitted under applicable law, the Company shall
indemnify, defend and hold Executive harmless from and against any and all
causes of action, claims, demands, liabilities, damages, costs and expenses of
any nature whatsoever (collectively, "Damages") directly or indirectly arising
out of or relating to Executive discharging Executive's duties hereunder on
behalf of the Company, so long as Executive acted in good faith within the
course and scope of Executive's duties with respect to the matter giving rise to
the claim or Damages for which Executive seeks indemnification.

9.       GENERAL PROVISIONS

         9.1      Assignment; Binding Effect. Neither the Company nor Executive
may assign, delegate or otherwise transfer this Agreement or any of their
respective rights or obligations hereunder without the prior written consent of
the other party. Any attempted prohibited assignment or delegation shall be
void. This Agreement shall be binding upon and inure to the

                                        6

<PAGE>

benefit of any permitted successors or assigns of the parties and the heirs,
executors, administrators and/or personal representatives of Executive.

         9.2      Notices. All notices, requests, demands and other
communications that are required or may be given under this Agreement shall be
in writing and shall be deemed to have been duly given where received if
personally delivered; when transmitted if transmitted by telecopy, electronic or
digital transmission method with electronic confirmation of receipt; the day
after it is sent, if sent for next-day delivery to a domestic address by
recognized overnight delivery service (e.g., FEDEX); and upon receipt, if sent
by certified or registered mail, return receipt requested. In each case notice
shall be sent to:

         If to the Company:        Aderis Pharmaceuticals, Inc.
                                   85 Main Street
                                   Hopkinton, MA 01748
                                   Attention: Chief Executive Officer
                                   Facsimile: 508-497-9553

         If to Executive:          Peter G. Savas
                                   10 Country Road
                                   Holliston, Massachusetts

Any party may change its address for the purpose of this Section 9.2 by giving
the other party written notice of its new address in the manner set forth above.

         9.3      Entire Agreement. This Agreement constitutes the entire
agreement of the parties, and supersedes all prior agreements, employment
letters, understandings and negotiations, whether written or oral, between the
Company and Executive with respect to the employment of Executive by the
Company.

         9.4      Amendments; Waivers. This Agreement may be amended or
modified, and any of the terms and covenants may be waived, only by a written
instrument executed by the parties hereto, or, in the case of a waiver, by the
party waiving compliance. Any waiver by any party in any one or more instances
of any term or covenant contained in this Agreement shall neither be deemed to
be nor construed as a further or continuing waiver of any such term or covenant
of this Agreement.

         9.5      Provision; Severable. In case any one or more provisions of
this Agreement shall be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained
herein shall not, in any way, be affected or impaired thereby. If any provision
hereof is determined by any court of competent jurisdiction to be invalid or
unenforceable by reason of such provision extending the covenants and agreements
contained herein for too great a period of time or over too great a geographical
area, or being too extensive in any other respect, such provision shall be
interpreted to extend only over the maximum period of time and geographical
area, and to the maximum extent in all other respects, as to which it is valid
and enforceable, all as determined by such court in such action.

                                        7

<PAGE>

         9.6      Attorneys' Fees. If any legal action, arbitration or other
proceeding, is brought for the enforcement of this Agreement, or because of an
alleged dispute, breach or default in connection with any of the provisions of
this Agreement, the prevailing party shall be entitled to recover reasonable
attorneys' fees and other costs incurred in that action or proceeding, including
any appeal of such action or proceeding, in addition to any other relief to
which that party may be entitled.

         9.7      Governing Law. This Agreement shall be construed, performed
and enforced in accordance with, and governed by the laws of the State of
Delaware without giving effect to the principles of conflict of laws thereof.

         9.8      Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which shall
constitute the same instrument.

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement
effective as of the date first written above.

THE COMPANY

ADERIS PHARMACEUTICALS, INC.
a Delaware corporation

By: /s/ Kenneth L. Rice, Jr.
    -------------------------------------------
    Kenneth L. Rice, Jr.
    Vice President and Chief Commercial Officer

EXECUTIVE

/s/ Peter G. Savas
---------------------------------
Peter G. Savas

                                        8

<PAGE>

                                    EXHIBIT A

              CONFIDENTIAL INFORMATION AND NONCOMPETITION AGREEMENT

To: Aderis Pharmaceuticals, Inc.                  Date:

         The undersigned, in consideration of and as a condition of my
employment or continued employment by you and/or by companies that you own,
control, or are affiliated with or their successors in business (collectively,
the "Company"), hereby agrees as follows:

         1.       Confidentiality. I agree to keep confidential, except as the
Company may otherwise consent in writing, and except for the Company's benefit,
not to disclose or make any use of at any time either during or subsequent to my
employment, any Inventions (as hereinafter defined), trade secrets, confidential
information, knowledge, data or other information of the Company relating to
products, franchises, processes, know-how, techniques, methods, designs,
formulas, test data, customer lists, business plans, marketing plans and
strategies, pricing strategies, or other subject matter pertaining to any
business of the Company or any of its affiliates, which I may produce, obtain,
or otherwise acquire during the course of my employment, except as herein
provided. I further agree not to deliver, reproduce or in any way allow any such
trade secrets, confidential information, knowledge, data or other information,
or any documentation relating thereto, to be delivered to or used by any third
parties without specific direction or consent of the Chairman of the Board or
the Chief Executive Officer of the Company. The provisions of this Section 1
shall not apply to such knowledge, data or other information that is generally
known to the public.

         2.       Conflicting Employment; Return of Confidential Material. I
agree that during my employment with the Company I will not engage in any other
employment, occupation, consulting or other activity relating to the business in
which the Company is now or may hereafter become engaged, or which would
otherwise conflict with my obligations to the Company. In the event my
employment with the Company terminates for any reason whatsoever, I agree to
promptly surrender and deliver to the Company all trade secrets, confidential
information, processes and records, including, but not limited to, designs,
formulae, test data, customer lists, business plans and strategies, Inventions
or other written memoranda, materials, equipment, drawings, documents and data
that I may obtain or produce during the course of my employment, and I will not
take with me any description containing or pertaining to any confidential
information, knowledge or data of the Company that I may produce or obtain
during the course of my employment.

                                        9

<PAGE>

         3.       Assignment of Inventions.

                  3.1      I hereby acknowledge and agree that the Company is
the owner of all Inventions. In order to protect the Company's rights to such
Inventions, by executing this Agreement I hereby irrevocably assign to the
Company all my right, title and interest in and to all Inventions to the
Company.

                  3.2      For purposes of this Agreement, "Inventions" shall
mean all discoveries, processes, designs, technologies, methods, techniques,
devices, or improvements in any of the foregoing or other ideas, whether or not
patentable or copyrightable and whether or not reduced to practice, made or
conceived by me (whether solely or jointly with others) during the period of my
employment with the Company that relate to the actual or demonstrably
anticipated business, work, or research and development of the Company, or
result from or are suggested by any task assigned to me or any work performed by
me for or on behalf of the Company.

                  3.3      Any discovery, process, design, method, technique,
technology, device, or improvement in any of the foregoing or other ideas,
whether or not patentable or copyrightable and whether or not reduced to
practice, made or conceived by me (whether solely or jointly with others) that I
develop entirely on my own time not using any of the Company's equipment,
supplies, facilities, or trade secret information ("Personal Invention") is
excluded from this Agreement provided such Personal Invention (a) does not
relate to the actual or demonstrably anticipated business, research and
development of the Company, and (b) does not result, directly or indirectly,
from any work performed by me for the Company.

         4.       Disclosure of Inventions. I agree that in connection with any
Invention, I will promptly disclose such Invention to the Board of Directors of
the Company in order to permit the Company to enforce its property rights to
such Invention in accordance with this Agreement. My disclosure shall be
received in confidence by the Company. If the Company in good faith decides not
to use an Invention, it will advise me of same and the rights to such Invention
will revert to me within a reasonable period of time.

         5.       Patents and Copyrights; Execution of Documents.

                  5.1      Upon request, I agree to assist the Company or its
nominee (at its expense) during and at any time subsequent to my employment in
every reasonable way to obtain for its own benefit patents and copyrights for
Inventions in any and all countries. Such patents and copyrights shall be and
remain the sole and exclusive property of the Company or its nominee. I agree to
perform such lawful acts as the Company deems to be necessary to allow it to
exercise all right, title and interest in and to such patents and copyrights.

                  5.2      In connection with this Agreement, I agree to
execute, acknowledge and deliver to the Company or its nominee upon request and
at its expense all documents, including assignments of title, patent or
copyright applications, assignments of such applications, assignments of patents
or copyrights upon issuance, as the Company may determine necessary or desirable
to protect the Company's or its nominee's interest in Inventions, and/or to use
in obtaining patents or copyrights in any and all countries and to vest title
thereto in the Company or its nominee to any of the foregoing.

                                       10

<PAGE>

         6.       Maintenance of Records. I agree to keep and maintain adequate
and current written records of all Inventions made by me (in the form of notes,
sketches, drawings, flowcharts, printouts, diskettes and other records as may be
specified by the Company), which records shall be available to and remain the
sole property of the Company at all times.

         7.       Prior Inventions. It is understood that all Personal
Inventions, if any, whether patented or unpatented, which I made prior to my
employment by the Company, are excluded from this Agreement. To preclude any
possible uncertainty, I have set forth on Schedule A attached hereto a complete
list of all of my prior Personal Inventions, including numbers of all patents
and patent applications and a brief description of all unpatented Personal
Inventions that are not the property of a previous employer. I represent and
covenant that the list is complete and that, if no items are on the list, I have
no such prior Personal Inventions. I agree to notify the Company in writing
before I make any disclosure or perform any work on behalf of the Company that
appears to threaten or conflict with proprietary rights I claim in any Personal
Invention. In the event of my failure to give such notice, I agree that I will
make no claim against the Company with respect to any such Personal Invention.

         8.       Other Obligations. I acknowledge that the Company from time to
time may have agreements with other persons, companies, entities, Governments or
agencies thereof, that impose obligations or restrictions on the Company
regarding Inventions made during the course of work thereunder or regarding the
confidential nature of such work. I agree to be bound by all such obligations
and restrictions and to take all actions necessary to discharge the Company's
obligations.

         9.       Trade Secrets of Others. I represent that my performance of
all the terms of this Agreement and as an employee of the Company does not and
will not breach any agreement to keep confidential proprietary information,
knowledge, or data acquired by me in confidence or in trust prior to my
employment with the Company, and I will not disclose to the Company, or induce
the Company to use, any confidential or proprietary information or material
belonging to any previous employer or others. I agree not to enter into any
agreement either written or oral in conflict herewith.

         10.      Post-Employment Activities.

                  10.1     For a period of one (1) year after the termination,
for any reason, of my employment with the Company, absent the Company's prior
written approval, I will not directly or indirectly engage in activities similar
or reasonably related to those in which I shall have engaged for the Company
during the two years immediately preceding termination, nor render services
similar or reasonably related to those which I shall have rendered during such
time to, any person or entity whether existing or hereafter established that
directly competes with (or proposes or plans to directly compete with) the
Company, or in other areas where the Company carries on a substantial amount of
business ("Direct Competitor"). In addition, I shall not entice, induce or
encourage any of the Company's other employees to engage in any activity that,
were it done by me, would violate any provision of this Agreement.

                  10.2     No provision of this Agreement shall be construed to
preclude me from performing the same services that the Company retains me to
perform for any person or entity

                                       11

<PAGE>

that is not a Direct Competitor of the Company upon the termination of my
employment (or any post-employment consultation) so long as I do not thereby
violate any term of this Agreement.

         11.      Remedies. My obligations under this Agreement shall survive
the termination of my employment with the Company. I acknowledge that a remedy
at law for any breach or threatened breach by me of the provisions of this
Agreement would be inadequate and I therefore agree that the Company shall be
entitled to injunctive relief in case of any such breach or threatened breach.

         12.      Modification. I agree that any subsequent change or changes in
my employment duties, salary or compensation or, if applicable, in any
Employment Agreement between the Company and me, shall not affect the validity
or scope of this Agreement.

         13.      Successors and Assigns. This Agreement shall be binding upon
my heirs, executors, administrators or other legal representatives and is for
the benefit of the Company, its successors and assigns.

         14.      Interpretation. IT IS THE INTENT OF THE PARTIES THAT in case
any one or more of the provisions contained in this Agreement shall, for any
reason, be held to be invalid, illegal or unenforceable in any respect, such
invalidity, illegality or unenforceability shall not affect the other provisions
of this Agreement, and this Agreement shall be construed as if such invalid,
illegal, or unenforceable provision had never been contained herein. MOREOVER,
IT IS THE INTENT OF THE PARTIES THAT if any provision of this Agreement is or
becomes or is deemed invalid, illegal or unenforceable or in case any one or
more of the provisions contained in this Agreement shall for any reason be held
to be excessively broad as to duration, geographical scope, activity or subject,
such provision shall be construed by amending, limiting and/or reducing it to
conform to applicable laws so as to be valid and enforceable or, if it cannot be
so amended without materially altering the intention of the parties, it shall be
stricken and the remainder of this Agreement shall remain in full force and
effect.

         15.      Waivers. No waiver of any right under this Agreement shall be
deemed effective unless contained in a writing signed by the party charged with
such waiver, and no waiver of any right arising from any breach or failure to
perform shall be deemed to be a waiver of any future such right or of any other
right arising under this Agreement. If either party should waive any breach of
any provision of this Agreement, he or it shall not thereby be deemed to have
waived any preceding or succeeding breach of the same or any other provision of
this Agreement.

         16.      Complete Agreement, Amendments. The foregoing is the entire
agreement of the parties with respect to the subject matter hereof, superseding
any previous oral or written communications, representations, understandings, or
agreements with the Company or any officer or representative thereof. Any
amendment to this Agreement or waiver by the Company of any right hereunder
shall be effective only if evidenced by a written instrument executed by the
parties hereto, upon authorization of the Company's Board of Directors.

         17.      Headings. The headings of the Sections contained in this
Agreement are inserted for convenience and reference only and in no way define,
limit, extend or describe the scope of this Agreement, or the intent of any
provision hereof, and shall not be deemed to constitute a part hereof nor to
affect the meaning of this Agreement in any way.

                                       12

<PAGE>

         18.      Governing Law. This Agreement shall be governed by and
construed in accordance with the internal laws of the Commonwealth of
Massachusetts, excluding its conflict of law principles.

         19.      Notices. All notices, requests, demands and communications
which are or may be required to be given hereunder shall be deemed effectively
given if and when sent by registered or certified mail, return receipt
requested, postage prepaid, to the following addresses:

                  If to the Company:

                  If to Employee:

         21.      Conflicts. In the event of any conflict between the provisions
of this agreement and the provisions of the Employment Agreement, the provisions
of the Employment Agreement will govern.

                                            Very truly yours,

Agreed:
Aderis Pharmaceuticals, Inc.

By: _____________________________________
    Kenneth L. Rice, Jr.
    Vice President and Chief Commercial Officer

                                       13

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00055-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00055-of-00352.parquet"}]]