Document:

<PAGE>   1
                                                                   EXHIBIT 10.30

                                                  [BAR CODE - US005925052A]

UNITED STATES PATENT [19]           [11]          PATENT NUMBER:       5,925,052
SIMMONS                             [45]          DATE OF PATENT:  JUL. 20, 1999
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[54]     UMBILICAL SURGICAL SCISSORS

[76]     Inventor:  PAUL L. SIMMONS, 8825 Laurel Dr.,
                    Pinellas Park, Fla. 33782

[21]     Appl. No.: 08/882,180

[22]     Filed:     JUN. 25, 1997

                         RELATED U.S. APPLICATION DATA

[60]     Provisional application No. 60/020,626, Jun. 26, 1996.

[51]     INT. CL.(6)................................................A61B 17/1412
[52]     U.S. CL.......................................606/120; 606/108; 606/139
[58]     FIELD OF SEARCH...........................................606/120, 108,
                                                                606/205, 210,139

[56]                              REFERENCES CITED

                                  U.S. PATENT DOCUMENTS

           352,245    11/1886    Hullhorst ............................. 606/120
         3,166,071     1/1965    Mayer ................................. 606/120
         4,428,374     1/1984    Auburn ................................ 606/120
         5,591,173     1/1997    Schifano .............................. 606/120

Primary Examiner -- Michael Buiz
Assistant Examiner -- (Jackie) Tan-Uyen Thi Ho
Attorney, Agent, or Firm -- A. W. Fisher, III

[57]                                  ABSTRACT

Umbilical surgical scissors to cut and clamp the umbilical cord following birth
comprising a scissor assembly including a first and second scissor member
selectively movable between a first and second position relative to each other
having a clamping assembly detachably mounted thereon by a clamp assembly
holder, the clamping assembly comprises a pair of clamping clips each including
a first and second clamping element movable between a normally open position and
a closed clamping position such that when the first and second scissor members
are moved from the first position to the second position the umbilical cord is
severed and the responding first and second clamping elements clamp the
umbilical cord therebetween.

                           9 CLAIMS, 2 DRAWING SHEETS

                                   [PICTURE]<PAGE>   1
                                                                   EXHIBIT 10.31
                                                      [Bar Code -- US005985929A]

UNITED STATES PATENT [19]           [11]     PATENT NUMBER             5,985,929
KERN                                [45]     DATE OF PATENT        Nov. 16, 1999
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[54]     COLD CHEMICAL STERILANT

[76]     Inventor:         Jerome Kern, 3508 W. Tacon St.,
                           Hillsborough County, Fla 33629

[21]     Appl. No.:        09/186,432

[22]     Filed:            Nov. 5, 1998

[51]     INT. CL.(6)................................................A01N 47/28
[52]     U.S. CL. ..................................................514/588
[58]     FIELD OF SEARCH............................................514/588, 592

[56]                            REFERENCES CITED

                             U.S. PATENT DOCUMENTS

         5,202,205         4/1993   Malbota.............................430/17
         5,451,251         9/1995   Mafime et al. ......................106/22 H

                            FOREIGN PATENT DOCUMENTS

         06023475 3/1991   Japan
         2059804  5/1996   Russian Federation
         1588820  8/1990   U.S.S.R.

PRIMARY EXAMINER         -- Jose G. Dees
ASSISTANT EXAMINER       -- Alton Pryor
ATTORNEY, AGENT, OR FIRM -- A. W. Fisher, III

[57]                                ABSTRACT

A cold chemical sterilant capable of killing a challenge of vegetative target
organisms including bacterial spores comprising a composition of interactive
constituents including a monohydric alcohol, an urea salt, a polyhydric alcohol,
a surface active agent and water in proportion by weight to destroy the
protective integrity of the walls of the bacterial spores, to penetrate the
walls of the bacterial spores and to kill the bacterial spores and other
vegetative target organisms.

                             14 CLAIMS, NO DRAWINGS<PAGE>   1

                                                                   EXHIBIT 10.32

[FLAG]  Office de la propriete     Canadian
        intellectuelle             Intellectual Property
        du Canada                  Office

        Un organisme               An agency of
        d'Industrie Canada         Industry Canada

                        Brevet canadien/Canadian Patent

                                     [LOGO]

     * Le commissaire aux brevets a requ une demande de delivrance de brevet
visant une invention. Ladite requere satisfait aux exigences de la Loi sur les
brevets. Le tirre et la description de l'invention figurent dans le memoire
descriptif, dont une copie faix partie integrante du present document.

     Le present brevet confere a son titulaire et a ses representants legaux,
pour une periode expirant vingt ans a compter de la date du depot de la demande
au Canada, le droit, la faculte et le privilege exclusif de fabricquer,
constuire, exploiter et vendre a d'autres, pour qu'ils l'exploitent, l'objet de
l'invention sauf jugement en l'espece rendu par un tribunal competent, et sous
reserve du paiement des taxes periodiques.

     * The Commissioner of Patents has received a petition for the grant of a
patent for an invention. The requirements of the Patent Act have been complied
with. The title and a description of the invention are contained in the
specification, a copy of which forms an integral part of this document. The
present patent grants to its owner and to the legal representatives of its
owner, for a term which expires twenty years from the filing date of the
application in Canada, the exclusive right, privilege and liberty of making,
constructing and using the invention and selling it to others to be used,
subject to adjudication before any court of competent jurisdiction, and subject
to the payment of maintenance fees.

BREVET CANADIEN                    2,166,810                     CANADIAN PATENT

Date a laquelle le brevet a 'ete' 2000/03/14            Date on which the patent
accorde er delivre                                        was granted and issued

Date du depot de la demande       1994/07/15      Filing date of the application

Date a laquelle la demande est    1995/01/25       Date on which the application
devenue accessible au public                              was made available for
pour consultation                                              public inspection

                -----------------------------------------------
                Commissaire aux brevets/Commissioner of Patents

CANADA                           2258 (CIPO 91)                           [LOGO]<PAGE>   1

                                                                   EXHIBIT 10.33

Int. Cl.: 5

Prior U.S. Cls.: 6, 18, 44, 46, 51 and 52                     Reg. No. 2,429,809

United States Patent and Trademark Office               Registered Feb. 20, 2001
--------------------------------------------------------------------------------

                                   TRADEMARK
                               PRINCIPAL REGISTER

                                [VIRAGUARD LOGO]

VERIDIEN CORPORATION (DELAWARE CORPORATION)
11800 28TH ST. NORTH
ST. PETERSBURG, FL 33716

         FOR: ALL PURPOSE ANTI-VIRAL SURFACE DISINFECTANT, IN CLASS 5
(U.S. CLS. 6, 18, 44, 46, 51 AND 52)

FIRST USE 6-21-1999; IN COMMERCE 6-21-1999

OWNER OF U.S. REG. NO. 2,186,559

SER. NO. 75-914,883, FILED 2-11-2000.

CHARLES L. JENKINS, EXAMINING ATTORNEY<PAGE>   1
Amendment to Credit Agreement

                                                                   EXHIBIT 10.18

[FIRST UNION Logo]

November 8, 2000

Denise M. Corey
Director, Treasury
Quintiles Transnational Corp.
PO Box 13979
Research Triangle Park, NC 27709-3979

         RE: The Credit Agreement dated as of August 7, 1998 by and among
         Quintiles Transnational Corp., as borrower (the "Borrower"), the
         Lenders referred to therein, and First Union National Bank, as
         Administrative Agent (as amended, restated, or otherwise modified, the
         "Credit Agreement").

Dear Denise:

The Borrower has requested that First Union National Bank ("First Union"), in
its capacity as Lender under the Credit Agreement, approve the following
modification and, subject to the conditions set forth below, First Union has
approved such modification of the Credit Agreement.

I. Section 9.2 of the Credit Agreement is hereby deleted in its entirety and the
following Section 9.2 is inserted in lieu thereof:

         "Section 9.2 Minimum Interest Coverage Ratio: The Borrower shall not
         permit, as of any fiscal quarter end, the ratio of (a) the sum of
         Adjusted EBITR for the four (4) consecutive fiscal quarter period
         ending on or immediately prior to such date plus the one-time $58.6
         million restructuring charge of the Borrower (to the extent deducted
         during such period) plus interest income to (b) the sum of Interest
         Expense plus Rental Expense, in each case for the four (4) consecutive
         fiscal quarter period ending on or immediately prior to such date, to
         be less than 1.75 to 1.00. For purposes of this covenant calculation,
         the effect of the Borrower's e-commerce initiative on the Borrower's
         financial performance will be excluded.

II. Any expenses and capital expenditures relating to the Borrower's e-commerce
initiative will be deemed to be an "investment" for purposes of Section 10.4(f)
of the

<PAGE>   2

Amendment to Credit Agreement

                                                                   EXHIBIT 10.18

Credit Agreement, subject to the limitation on investments equal to an
amount equal to 15% of Tangible Net Worth, as set forth in the proviso of such
Section 10.4.

In consideration for this amendment, Quintiles can choose to (1) pay an
amendment fee of 5 basis points ($75,000) or (2) place on deposit with First
Union's Capital Management Group ("CMG") a minimum of $30,000,000 in cash to be
managed by CMG at the direction of Quintiles. The acceptance and payment of
option (1) or the acceptance and agreement to a transfer of cash prior to
November 30, 2000 pursuant to option (2) is a condition to the effectiveness of
this modification letter.

All other terms, conditions and provisions of the Note and Loan Documents remain
unchanged and in full force and effect, and the Borrower hereby confirms that
all of the Representations and Warranties contained in the Credit Agreement are
true as of the date hereof.

Please indicate your approval of the foregoing by executing the appropriate
signature block below.

Sincerely.

/s/ Mendel Lay

Mendel Lay
Senior Vice President
First Union National Bank

AGREED TO AND ACCEPTED
AS OF THIS 8th DAY OF NOVEMBER, 2000:

QUINTILES TRANSNATIONAL CORP.

By:      /s/ James L. Bierman
         --------------------------------------------
Name:    James L. Bierman
         --------------------------------------------
Title:   Chief Financial Officer
         --------------------------------------------

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