Document:

OPHTHALMIC
      TECHNOLOGIES INC.

    

    

    SHARE
      PURCHASE AGREEMENT

    

     

    April 11,
      2007

    

     

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    OPHTHALMIC
      TECHNOLOGIES INC

    

    SHARE
      PURCHASE AGREEMENT

    

    

    This
      Share Purchase Agreement
      (the
“Agreement”)
      is
      made and entered into as of April 11, 2007, by and among Ophthalmic
      Technologies, Inc.,
      an
      Ontario corporation (the “Company”);
      and
      Exegenics Inc., a Delaware corporation (the “Investor”).
      

    

    Recitals

    

    
      	Whereas,	
              the
                Company has authorized the issuance from treasury of an aggregate
                of 67.94
                common shares (the “Shares”);
                and

            

    

    

    
      	Whereas,	
              the
                Investor desires to purchase the Shares on the terms and conditions
                set
                forth herein; and 

            

    

    

    
      	Whereas,	
              the
                Company desires to issue the Shares to Investor on the terms and
                conditions set forth herein.

            

    

    

    Now
      Therefore,
      in
      consideration of the foregoing recitals and the mutual promises,
      representations, warranties, and covenants hereinafter set forth, the parties
      hereto agree as follows: 

    

    
      
        	1.	
                Agreement
                  to Sell and Purchase

              

      

    

     

    
      
        	1.1	
                Issuance
                  and Purchase. Subject
                  to the terms and conditions hereof, at the Closing (as hereinafter
                  defined) the Company hereby agrees to issue to the Investor, and
                  the
                  Investor agrees to purchase from the Company, that number of common
                  shares
                  of the Company equivalent to, but not exceeding, one-third (1/3)
                  of the
                  Company’s issued and outstanding share capital, for an aggregate purchase
                  price of US$5 million (the “Investment Amount”), constituting, at the
                  Closing, 67.94 Shares at a purchase price of US $73,594.35 per
                  Share.

              

      

    

    

    
      	1.2	
              Authorization
                of Shares.
                The Shares, when issued and allotted in accordance herewith: (a)
                will be
                duly authorized, validly issued, fully paid, non-assessable and free
                of
                pre-emptive or similar rights; (b) shall have the rights, preferences
                and
                privileges as set forth in the Articles of Incorporation of the Company
                attached hereto as Exhibit
                1.2
                (the “Articles”);
                and (c) will be free and clear of any liens, security interests or
                third
                party rights created by the
                Company.

            

    

    

    
      	1.3	
              Investor’s
                Proportion of Company Share Capital.
                As
                stated in Section 1.1 above, the Shares shall constitute on the Closing
                Date (as defined below), one-third (1/3) of the Company’s issued and
                outstanding share capital on a fully diluted basis, after giving
                effect to
                the consummation of all transactions contemplated at the Closing,
                subject
                to Section 1.4 below, and treating all options, warrants, convertible
                securities and rights to purchase securities of the Company, on an
                as-exercised and as-converted basis (“Fully
                Diluted Basis”),
                all as reflected in the Company’s capitalization table attached hereto as
                Exhibit
                1.3. 

            

    

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    
      	
              1.4

            	
              Cancellation
                of Impugned Shareholder Shares. Notwithstanding
                Section 1.3 above, the Parties acknowledge that it is their present
                intention that for the purposes of resolving certain issues as between
                the
                Company and any Impugned Shareholders (as defined below) which will
                result
                in the purchase for cancellation (“Cancellation”) by the Company, of all
                or part of the share capital of the Company held by such Impugned
                Shareholders, that if, as a consequence of any such Cancellation,
                the
                shareholding of the Investor then exceeds one-third (1/3) of the
                share
                capital of the Company taken as a proportion to the holdings of the
                shareholders remaining after such Cancellation (the “Original
                Shareholders”, which term expressly
                excludes
                any Impugned Shareholder), then, in each such instance, the Investor
                shall
                sell, for nominal consideration, and the Original Shareholders shall
                purchase, in their Pro-Rata Proportions (as defined below), that
                number of
                the Shares held by the Investor necessary to adjust the proportionate
                shareholding of the Investor so that it constitutes only one-third
                (1/3)
                of the fully-diluted issued and outstanding share capital of the
                Company
                as at the date of each such Cancellation.

            

    

    

    
      	
              1.5

            	
              Financing
                of Cancellation.
                Subject to Section 1.7 below, in the event of any such Cancellation
                of
                Impugned Shareholder shareholdings as contemplated in Section 1.4
                above,
                the Company shall pay only a nominal amount of the aggregate consideration
                payable in respect of all such Cancellations taken together. Any
                additional funds required, to the extent such required funds exceed
                nominal amounts, shall be borne by the Original Shareholders (as
                defined
                in Section 1.4) in their Pro-Rata Proportions, or in such proportions
                as
                the Original Shareholders may agree, in writing, as at the time of
                such
                Cancellation. Alternatively, and in the sole discretion of the Original
                Shareholders, where the Original Shareholders are required to bear
                the
                cost of any such Cancellation of Impugned Shareholder shareholdings,
                the
                Original Shareholders may elect instead to purchase such shareholdings
                from the Impugned Shareholder, at the transfer price determined under
                the
                relevant dispute settlement agreement, in their Pro-Rata Proportions,
                or
                in such proportions as the Original Shareholders may agree, in writing,
                as
                at the time of such purchase provided, however, that any such purchase
                shall not have the effect of reducing the proportionate shareholding
                of
                the Investor so that it constitutes less than one-third (1/3) of
                the
                fully-diluted issued and outstanding share capital of the Company
                as at
                the date of each such purchase.

            

    

    

    
      	
              1.6

            	
              Defined
                Terms.
                For the purposes of Sections 1.4 and 1.5 above, “Pro-Rata Proportion”
                means, with respect to any Original Shareholder as at the date of
                each
                such Cancellation, the percentage of Shares it owned directly or
                indirectly as at the Closing is of the total number of the issued
                and
                outstanding Shares of the Company as at the Closing time, without
                taking
                into account the shareholdings of any Impugned Shareholder. For greater
                certainty, the Pro-Rata Proportion with respect to any Original
                Shareholder will be the fraction that has as its numerator the total
                number of issued and outstanding Shares of the Company held by such
                Original Shareholder as at the Closing time and as its denominator
                the
                total number of all issued and outstanding Shares of the Company
                held by
                all Original
                Shareholders as at the Closing time. For the purposes Sections 1.4
                and 1.5
                above, “Impugned Shareholder” means each of Nidek Co. Ltd. (“Nidek”) and
                Jean-Paul Chaduc (“Chaduc”).

            

    

    

    
      	
              1.7

            	
              Special
                Provisions - Nidek Cancellation. Notwithstanding
                Section 1.5 above, the Parties acknowledge that it is their present
                intention that, for the purposes of financing a Cancellation of Nidek
                shares, the Company shall pay the purchase price of the shares up
                to the
                amount otherwise paid to the Company by Nidek as part of any settlement
                agreement. Any funds required in excess of this amount, to the extent
                such
                required funds exceed nominal amounts, shall be borne by the Original
                Shareholders in accordance with the provisions of Section 1.5 above.
                

            

    

    

    
      
        
        

      

      
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      	2.	
              Closing,
                Registration and Payment

            

    

    

    
      	2.1	
              Closing.
                The closing of the sale and purchase of the Shares under this Agreement
                (the “Closing”)
                shall take place at 10:00 a.m. on April 11, 2007, at the Company's
                offices or at such other time or place as the Company and Investor
                may
                mutually agree (such date is hereinafter referred to as the “Closing
                Date”).

            

    

    

    
      	2.2	
              Transactions
                at Closing.
                At the Closing, the following transactions and actions shall be taken, and
                all such transactions and actions shall be deemed to take place
                simultaneously:

            

    

    

    2.2.1  The
      Investor shall pay to the Company the sum of US $5 million, by way of wire
      or
      electronic transfer of immediately available funds to the Company’s bank account
      or by such other form of payment acceptable to the Company;

    

    2.2.2  The
      Company shall issue to the Investor 67.94 Shares.

    

    2.2.3  The
      Company shall further deliver to the Investor the following
      documents:

    

    (a)  Validly
      executed share certificate, issued in the name of Exegenics Inc., and
      representing the Shares issued to the Investor at the Closing;

    

    (b)  A
      copy of
      the resolutions of the Board of Directors of the Company, approving: (i) the
      execution, delivery and performance of this Agreement; and (ii) the issuance
      of
      the Shares to the Investor at the Closing, against and subject to payment of
      the
      Investment Amount; 

    

    (c)  Any
      other
      document or instrument to be provided by the Company reasonably necessary or
      expedient to give full effect to the sale and purchase of the Shares and
      otherwise to the consummation of all the transactions contemplated
      herein.

    

    
      	2.3	
              Conditions
                to Closing by the Investor.
                The obligations of the Investor to take any action required of it
                hereunder to be taken at the Closing are subject to the fulfillment
                at or
                before the Closing of the following conditions precedent, any one
                or more
                of which may be waived in whole or in part by the Investor in its
                sole
                discretion:

            

    

    

    2.3.1  Representations
      and Warranties.
      The
      representations and warranties made by the Company in this Agreement shall
      have
      been true and correct in all material respects when made, and shall be true
      and
      correct in all material respects as of the Closing as if made on the date of
      the
      Closing.

    

    
      
        
        

      

      
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    2.3.2  Covenants.
      All
      covenants, agreements, and conditions contained in this Agreement to be
      performed or complied with by the Company prior to or at the Closing shall
      have
      been performed or complied with in all material respects, prior to or at the
      Closing.

    

    2.3.3  Consents
      etc.
      The
      Company shall have secured all permits, consents, approvals, resolutions and
      authorizations that shall be necessary or required lawfully for the Company
      to
      consummate this Agreement and to issue the Shares to be purchased by the
      Investor at the Closing. 

    

    2.3.4  Delivery
      of Documents.
      All the
      documents to be delivered by the Company to the Investor at the Closing shall
      be
      in form and substance reasonably satisfactory to the Investor.

    

    2.3.5  Proceedings
      and Documents.
      All
      corporate and other proceedings in connection with the transactions contemplated
      by this Agreement and all documents and instruments incident to such
      transactions shall be reasonably satisfactory in substance and form to the
      Investor, and the Investor shall have received all such counterpart originals
      or
      certified or other copies of such documents as the Investor may reasonably
      request.

    

    2.3.6  No
      Judgment or Order.
      There
      shall not be on the date of the Closing any judgment or order of a court of
      competent jurisdiction or any ruling, regulation or order of any authority
      which
      would prohibit or have the effect of preventing consummation of the transactions
      contemplated by this Agreement.

    

    
      	2.4	
              Conditions
                to Closing by the Company.
                The obligations of the Company to take any action required of the
                Company
                hereunder to be taken at the Closing are subject to the fulfillment
                at or
                before the Closing of the following conditions, which conditions
                may be
                waived in whole or in part by the Company, and which waiver shall
                be at
                the sole discretion of the Company:

            

    

    

    2.4.1  Covenants.
      All
      covenants, agreements and conditions contained in this Agreement to be
      performed, or complied with, by the Investor prior to or at the Closing shall
      have been performed or complied with by the Investor prior to or at the
      Closing.

    

    2.4.2  Representations
      and Warranties.
      The
      representations and warranties made by the Investor in this Agreement shall
      have
      been true and correct when made, and shall be true and correct as of the date
      of
      the Closing.

    

    2.4.3  Consents,
      etc.
      The
      Company shall have secured all consents and approvals, as provided in Section
      2.3.3 above.

    

    2.4.4  No
      Judgment or Order.
      There
      shall not be on the date of the Closing any judgment or order of a court of
      competent jurisdiction or any ruling, regulation or order of any authority
      which
      would prohibit or have the effect of preventing consummation of the transactions
      contemplated by this Agreement.

    

    
      
        
        

      

      
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      	3.	
              Representations
                and Warranties of the
                Company

            

    

    

    Except
      as
      set forth on a Schedule of Exceptions delivered by the Company to the Investor
      at the Closing, which is attached hereto as Exhibit 3,
      the
      Company hereby represents and warrants to the Investor as of the date of this
      Agreement as set forth below. 

    

    
      	3.1	
              Organization,
                and Qualification.
                The Company is a Company duly organized and validly existing under
                the
                laws of Ontario, Canada. The Company has all requisite corporate
                power and
                authority to own and operate its properties and assets, to issue
                and sell
                the Shares, and to carry out the provisions of this Agreement and
                to carry
                on its business as presently conducted.

            

    

    

    
      	3.2	
              Subsidiaries.
                The Company does not own or control any equity security or other
                interest
                of any other corporation, limited partnership or other business
                entity.

            

    

    

    
      	3.3	
              Capitalization;
                Voting Rights.
                

            

    
      	 	 	 	 

      	 	(a)	The authorized share capital of the Company, immediately
              prior to the Closing, consists of (i) an unlimited number of shares
              of Common Stock with no par value (“Common
              Stock”),
              of which 132.48 shares are issued and outstanding;	 

      	 	 	 	 

      	 	(b)	Other than as set forth on the Schedule of Exceptions
              and
              in Note 8 of the Financial Statements, there are no outstanding
              options, warrants, rights (including conversion or preemptive rights
              and
              rights of first refusal), proxy or shareholder agreements, or agreements
              of any kind for the purchase or acquisition from the Company of any
              of its
              securities. 	 

      	 	 	 	 

      	 	(c)	All issued and outstanding shares of the Company’s Common
              Stock (i) have
              been duly authorized and validly issued and are fully paid and
              non-assessable, and (ii) were issued in compliance with all applicable
              Canadian laws concerning the issuance of such securities.	 

      	 	 	 	 

      	 	
              (d)

            	
              The
                rights, preferences, privileges and restrictions of the Shares are
                as
                stated in the
                Articles. The consummation of the transactions contemplated hereunder
                will
                not result in any anti-dilution adjustment or other similar adjustment
                to
                any outstanding securities or instruments of the Company. When issued
                in
                compliance with the law, the provisions of this Agreement and the
                Articles, the Shares will be validly issued, fully paid and
                non-assessable, and will be free of any liens or encumbrances other
                than
                liens and encumbrances created by or imposed upon the Investor;
                provided,
                however,
                that the Shares may be subject to restrictions on transfer under
                U.S.,
                Canadian or any applicable state or provincial securities laws as
                set
                forth herein, or as otherwise required by such laws at the time a
                transfer
                is proposed.

            	
            

    

    

    
      	 	
              (e)

            	
              Exhibit
                1.3 describes the capitalization of the Company immediately prior
                to the
                Closing. 

            

    

    

    
      
        
        

      

      
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      	3.4	
              Authorization.
                The Company has the full power and authority to execute, enter into
                and
                perform its obligations under this Agreement. The Agreement has been
                duly
                authorized by all of the necessary corporate actions, and the same
                constitute or will constitute (as applicable) valid and legally binding
                obligations of the Company, enforceable against it in accordance
                with
                their respective terms, all except as may be limited by applicable
                bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance,
                and any other laws of general application affecting enforcement of
                creditors' rights generally, and as limited by laws relating to the
                availability of specific performance, injunctive relief or other
                equitable
                remedies. 

            

    

    

    
      	3.5	
              Financial
                Statements.
                The Company has made available to the Investor its Financial Reports
                as of
                April 30, 2006 (the “Financial
                Statements”
                and the “Financial
                Statement Date”
                respectively), copies of which are attached hereto as Exhibit
                3.5.
                The Financial Statements, together with the notes thereto, are complete
                and correct in all material respects, have been prepared in accordance
                with generally accepted accounting principles in Canada, applied
                on a
                consistent basis throughout the periods indicated, except as disclosed
                therein.

            

    

    

    
      	3.6	
              Liabilities.
                Except as set forth in the Schedule of Exceptions, the Company has
                no
                debts and, to the best of its knowledge, knows of no contingent
                debts, not
                disclosed in the financial statements, except current debts incurred
                in
                the ordinary course of business which have not been, either in any
                individual case or in the aggregate, materially adverse.
                

            

    

    

    
      	3.7	
              Agreements;
                Action.
                Except as set forth in the Schedule of Exceptions, there are no
                agreements, understandings, instruments, contracts, proposed transactions,
                judgments, orders, writs or decrees to which the Company is a party
                or to
                its knowledge by which it is bound which may involve (i) obligations
                (contingent or otherwise) of, or payments to, the Company in excess
                of
                $10,000, or (ii) the transfer or license of any patent, copyright,
                trade
                secret or other proprietary right to or from the Company (other than
                licenses arising from the purchase of “off the shelf” or other standard
                products).

            

    

    

    
      	3.8	
              Obligations
                to Related Parties.
                Except as set forth in the Schedule of Exceptions or the Financial
                Statements, there are no obligations of the Company to officers,
                directors, shareholders, or employees of the Company other than (a)
                for
                payment of salary for services rendered and (b) reimbursement for
                reasonable expenses incurred on behalf of the Company. No officer,
                director or shareholder, or any member of their immediate families,
                is,
                directly or indirectly, interested in any material contract with
                the
                Company (other than such contracts as relate to any such person’s
                ownership of shares or other securities of the Company). The Company
                is
                not a guarantor or indemnitor of any indebtedness of any other person
                or
                corporation. 

            

    

    

    
      	3.9	
              Changes.
                Except as set forth in the Schedule of Exceptions, since the Financial
                Statement Date, there has not been to the Company’s knowledge:
                

            

    

    

    
      	
            	(a)	
              Any
                change in the assets, liabilities or operations of the Company from
                that
                reflected in the Financial Statements, other than changes in the
                ordinary
                course of business, none of which individually or in the aggregate
                has had
                a material adverse effect on
                such assets, liabilities or operations of the Company; Since the
                date of
                the Financial statements it is expected that sales will decrease
                for
                fiscal 2007 as a result of ongoing supply issues with the Company’s major
                supplier for the OCT/SLO product, Newport Corporation. The Company’s
                payable to Newport Corporation has also increased. Both these issues
                have
                been addressed to the satisfaction of Newport and the Company in
                a
                purchase order, a draft of which is attached hereto, which deals
                with both
                supply and payable issues.

            

      	 	 	 

      	 	(b)	Any damage, destruction or loss whether
              or not
              covered by insurance, materially and adversely affecting the properties,
              business or prospects or financial condition of the Company;
              

    

     

    
      
        
        

      

      
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      	 	(c)	Any change, except in the ordinary
              course of
              business, in the contingent obligations of the Company by way of guaranty,
              endorsement, indemnity, warranty or otherwise;

    

     

    
      	 	(d)	Any waiver by the Company of a valuable
              right
              or of a material debt owed to it; 

      	 	 	 

      	 	(e)	Any direct or indirect loans by the
              Company to
              any shareholder, employee, officer or director of the
              Company,

      	 	 	 

      	 	(f)	Any material change in any compensation
              arrangement or agreement with any employee, officer, director or
              shareholder;

      	 	 	 

      	 	(g)	Any declaration or payment of any dividend
              or
              other distribution of the assets of the Company;

      	 	 	 

      	
            	(h)	
              Any
                debt, obligation or liability incurred, assumed or guaranteed by
                the
                Company, except those for immaterial amounts and for other liabilities
                incurred in the ordinary course of
                business;

            

      	 	 	 

      	 	(i)	Any sale, assignment or transfer of
              any
              patent, trademarks, copyrights, trade secret or other intangible assets;
              or

      	 	 	 

      	 	(j)	Any change in any material agreement
              to which
              the Company is a party or by which it is
              bound.

    

     

    
      	3.10	
              Title
                to Properties and Assets; Liens, Etc.
                The Company has good and marketable title to its properties and assets,
                including the properties and assets reflected in the Financial Statements,
                and good title to its leasehold estates, in each case subject to
                no
                mortgage, pledge, lien, lease, encumbrance or charge (a “Lien”), other
                than (a) those resulting from taxes which have not yet become delinquent,
                (b) minor liens and encumbrances which do not materially detract
                from the
                value of the property subject thereto or materially impair the operations
                of the Company, and (c) those that have otherwise arisen in the ordinary
                course of business. The Company is in compliance with all material
                terms
                of each agreement to which it is a party or is otherwise bound.
                

            

    

    

    
      	3.11	
              Intellectual
                Property.
                

            

    

    

    
      	
            	(a)	
              To
                the best of its knowledge the Company owns or possesses sufficient
                legal
                rights to all patents, trademarks, service marks, trade names, copyrights,
                trade secrets, licenses, information and other proprietary rights
                and
                processes necessary for its business as now conducted and as presently
                proposed to be conducted, without any known infringement of the rights
                of
                others. There are no outstanding options, licenses or agreements
                of any
                kind relating to the foregoing proprietary rights, nor is the Company
                bound by or a party to any options, licenses or agreements of any
                kind
                with respect to the patents, trademarks, service marks, trade names,
                copyrights, trade secrets, licenses, information and other proprietary
                rights and processes of any other person or entity other than such
                licenses or agreements arising from the purchase of “off the shelf” or
                standard products. 

            

      	 	 	 

    

     

    
      
        
        

      

      
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        	 	(b)	Except with respect to the Zeiss
                letters,
                which have been disclosed to the Investor, the Company has not received
                any communications alleging that the Company has violated by conducting
                its business as presently proposed, would violate any of the patents,
                trademarks, service marks, trade names, copyrights or trade secrets
                or
                other proprietary rights of any other person or entity, nor is the
                Company
                aware of any basis therefore.

      

       

    

    
      	 	(c)	None of the key employees of the Company
              (as
              named in Section 3.16 hereto) is obligated under any contract (including
              licenses, covenants or commitments of any nature) or other agreement,
              or
              subject to any judgment, decree or order of any court or administrative
              agency, that would interfere with their duties to the Company or that
              would conflict with the Company’s business as presently proposed to be
              conducted. Each former and current employee, officer and consultant
              of the
              Company has executed a proprietary information and inventions agreement.
              No former and current employee, officer or consultant of the Company
              has
              excluded works or inventions made prior to his or her employment with
              the
              Company from his or her assignment of inventions pursuant to such
              employee, officer or consultant’s proprietary information and inventions
              agreement.

    

     

    
      	3.12	
              Compliance
                with Other Instruments.
                The Company is not in violation or default of any term of its current
                Articles, or of any provision of any mortgage, indenture, contract,
                agreement or instrument to which it is party or by which it is bound,
                or
                of any judgment, decree, order, writ. The execution, delivery, performance
                of, and compliance with this Agreement, and the issuance and sale
                of the
                Shares pursuant hereto, will not, with or without the passage of
                time or
                giving of notice, result in any such violation, or be in conflict
                with or
                constitute a default under any such term, or result in the creation
                of any
                mortgage, pledge, lien, encumbrance or charge upon any of the properties
                or assets of the license, authorization or approval applicable to
                the
                Company, it business or operations or any of its assets or properties.
                

            

    

    

    
      
        	3.13	
                Litigation.
                  Except as set forth in the Schedule of Exceptions, there is no
                  action,
                  suit, proceeding or investigation pending or, to the Company’s knowledge,
                  currently threatened against the Company that questions the validity
                  of
                  this Agreement, or the right of the Company to enter into any of
                  such
                  agreements, or to consummate the transactions contemplated hereby
                  or
                  thereby, or which would reasonably be expected to result, either
                  individually or in the aggregate, in any material adverse change
                  in the
                  assets, conditions, affairs or prospects of the Company, financially
                  or
                  otherwise, or any change in the current equity ownership of the
                  Company,
                  nor is the Company aware that there is any basis for any of the
                  foregoing.
                  

              

      

    

    

    
      
        
        

      

      
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        	3.14	
                Tax
                  Returns and Payments.
                  The Company has filed all tax returns required to be filed by it.
                  All
                  taxes shown to be due and payable on such returns, any assessments
                  imposed, and to the Company’s knowledge all other taxes due and payable by
                  the Company on or before the Closing, have been paid or will be
                  paid prior
                  to the time they become delinquent. The Company has no knowledge
                  of any
                  liability of any tax to be imposed upon its properties or assets
                  as of the
                  date of this Agreement that is not adequately provided for.
                  

              

      

    

    

    
      
        	3.15	
                Employees.
                  The Company has no collective bargaining agreements with any of
                  its
                  employees. 

              

      

    

    

    
      
        	3.16	
                Obligations
                  of Key Employees.
                  Each Key employee of the Company is currently devoting substantially
                  all
                  of his or her business time to the conduct of the business of the
                  Company.
                  The Company is not aware that any key employee of the Company is
                  planning
                  to work less than full time at the Company in the future. No Key
                  Employee
                  is currently working or, to the Company’s knowledge, plans to work for a
                  competitive enterprise, whether or not such key employee is or
                  will be
                  compensated by such enterprise. The Company’s Key Employees have executed
                  with the Company employment agreements that include a non-competition
                  and
                  confidentiality provisions. For the purpose of this Section, the
                  term “Key
                  Employee” shall refer to Richard Weitz, Gerald Weiss and Justin Pedro.
                  Gerald Weiss is also involved in a property management company
                  that
                  manages amongst other, family controlled real estate. Gerald Weiss
                  is not
                  involved in the day to day management of the property management
                  company.

              

      

    

    

    
      
        	3.17	
                Registration
                  Rights and Voting Rights.
                  The
                  Company has not agreed to grant any registration rights, including
                  piggyback rights, to any person or
                  entity.

              

      

    

    

    
      	3.18	
              Compliance
                with Laws; Permits.
                The Company is not aware of any violation of any applicable statute,
                rule,
                regulation, order or restriction of any domestic or foreign government
                or
                any instrumentality or agency thereof in respect of the conduct of
                its
                business or the ownership of its properties which violation would
                materially and adversely affect the business, assets, liabilities,
                financial condition, operations or prospects of the Company No
                governmental orders, permissions, consents, approvals or authorizations
                are required to be obtained and no registrations or declarations
                are
                required to be filed in connection with the execution and delivery
                of this
                Agreement and the issuance of the Shares, except such as has been
                duly and
                validly obtained or filed, or with respect to any filings that must
                be
                made, or tax to be paid, after the Closing, as will be filed in a
                timely
                manner. The Company has all franchises, permits, licenses and any
                similar
                authority necessary for the conduct of its business as now being
                conducted
                by it, the lack of which could materially and adversely affect the
                business, properties or financial condition of the Company and believes
                it
                can obtain, without undue burden or expense, any similar authority
                for the
                conduct of its business as planned to be conducted.

            

    

    

    
      	3.19	
              Full
                Disclosure.
                The Company has provided the Investor with all information requested
                by
                the Investor in connection with its decision to purchase the Shares
                including all information reasonably necessary to make such investment
                decision. To the Company’s knowledge, neither this
                Agreement, the exhibits and schedules hereto nor any other document
                delivered by the Company to Investor or their attorneys or agents
                in
                connection herewith or therewith or with the transactions contemplated
                hereby or thereby, contain any untrue statement of a material fact
                nor, to
                the best of the Company’s knowledge, omit to state a material fact
                necessary in order to make the statements contained herein or therein
                not
                misleading 

            

    

    

    
      
        
        

      

      
        9

        
          

        

      

      
        
        

      

    

    
      	3.20	
              Insurance.
                The Company has general commercial, product liability, fire and casualty
                insurance, with coverage customary for companies similarly situated
                to the
                Company.

            

    

    

    
      	4.	
              Representations
                and Warranties of the Investor

            

      	 	 

      	 	The Investor hereby represents and
              warrants to
              the Company as follows (such representations and warranties do not
              lessen
              or obviate the representations and warranties of the Company set forth
              in
              this Agreement). 

    

     

    
      
        	4.1	
                Requisite
                  Power and Authority.
                  Investor has all necessary power and authority under all applicable
                  provisions of law to execute and deliver this Agreement and to
                  carry out
                  its provisions. All action on Investor’s part required for the lawful
                  execution and delivery of this Agreement has been or will be effectively
                  taken prior to the Closing. Upon its execution and delivery, this
                  Agreement will be a valid and binding obligation of Investor, enforceable
                  in accordance with its terms, except (a) as limited by applicable
                  bankruptcy, insolvency, reorganization, moratorium or other laws
                  of
                  general application affecting enforcement of creditors’ rights, and (b) as
                  limited by general principles of equity that restrict the availability
                  of
                  equitable remedies. 

              

      

    

    

    
      
        	4.2	
                Investment
                  Representations.
                  Investor hereby represents and warrants as follows:
                  

              

      

       

      
        
          	
                	(a)	
                  Investor
                    Bears Economic Risk.
                    Investor has substantial experience in evaluating and investing
                    in private
                    placement transactions of securities in companies similar to
                    the Company
                    so that it is capable of evaluating the merits and risks of its
                    investment
                    in a development-stage company and has the capacity to protect
                    its own
                    interests. Investor must bear the economic risk of this investment
                    indefinitely. Investor understands that the Company has no present
                    intention to offer to the public or register the Shares or any
                    of its
                    Common Stock. Investor is aware that its investment should be
                    regarded as
                    highly speculative and may cause it substantial or total loss
                    of its
                    investment.

                

        

         

      

    

    
      
        	
              	
                (b)

              	
                Entirely
                  for own Account; Accredited Investor. Investor
                  is purchasing the Shares for investment for its account, not as
                  nominee or
                  agent, and not with the current view to, or for resale in connection
                  with,
                  any distribution thereof. It is an “accredited investor” within the
                  meaning of (i) Rule 501 of Regulation D promulgated under the U.S.
                  Securities Act of 1933, as amended; and (ii) National Instrument
                  45-106 -
                  Prospectus and Registration Exemptions. It is able to bear the
                  economic
                  risks of the investment in the Company and, consequently, without
                  limiting
                  the generality of the foregoing, is able to hold the Shares for
                  an
                  indefinite period of time and has a sufficient net worth to sustain
                  a loss
                  of its entire investment in the Company in the event such loss
                  should
                  occur. 

              

      

       

      
        	
              	(c)	
                InvestorCan
                  Protect Its Interest.
                  Investor represents that by reason of its, or its management’s, business
                  or financial experience, Investor has the capacity to protect its
                  own
                  interests in connection with the transactions contemplated in the
                  Agreement. Further, Investor is aware of no publication of any
                  advertisement or promotion in connection with the transactions
                  contemplated in the Agreement.

              

        	 	 	 

      

       

      
        
          
          

        

        
          10

          
            

          

        

        
          
          

        

      

       

      
        	 	(d)	
                Company
                  Information.
                  Investor has received and reviewed such data provided to it by
                  the Company
                  regarding the Company as it deemed appropriate and has had an opportunity
                  to discuss the Company’s business, management and financial affairs with
                  directors, officers and management of the Company and has had the
                  opportunity to review the Company’s operations and facilities. Investor
                  has also had the opportunity to ask questions of and receive answers
                  from,
                  the Company and its management regarding the terms and conditions
                  of this
                  investment.

              

        	 	 	 

        	 	(e)	
                No
                  Public
                  Market.
                  Investor understands that the Shares that it is purchasing are
                  characterized as “restricted securities” inasmuch as they are being
                  acquired from the Company in a transaction not involving a public
                  offering. Investor acknowledges that the Shares may be held indefinitely
                  and understands that no public market now exists for any of the
                  Shares
                  issued by the Company and that the Company has made no assurances
                  that a
                  public market will ever exist for the Company’s shares.
                  

              

        	 	 	 

        	 	(f) 	
                Legend.
                  Investor acknowledges that the certificates evidencing the Shares
                  will
                  bear the following legend:

              

      

       

    

    
      “UNLESSPERMITTED
        UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE
        THE
        SECURITY BEFORE AUGUST 12, 2007.” 

    

    

    6. OPTION
      ARRANGEMENTS 

    

    6.1 For
      and
      in consideration of the Closing of the purchase and sale transaction
      contemplated herein, each of the Company shareholders listed on the signature
      page hereto hereby grant to the Investor an options (collectively, the
“Options”), granting it the irrevocable right to purchase from such shareholder
      all of such shareholder’s right, title and interest in and to the capital stock
      of the Company (the “Selling Shareholders”). The Company undertakes to dedicate
      best efforts to procure, within four (4) weeks from the date hereof, Options
      from any other shareholders of the Company not executing this agreement. The
      aforesaid options shall extend for the greater of a period of (i) six (6) months
      from the date of this Agreement and (ii) three (3) months after completion
      of
      the audits described in clause (c) below and shall vest effective the date
      hereof, at an exercise price per share to be determined in accordance with
      the
      following formula. The exercise price per share for each option shall be payable
      in shares of the common stock of the Investor, par value $0.01 per share (the
      “eXeg Common Stock”), and shall be equal to the Aggregate Exercise Price divided
      by 135.88. The Aggregate Exercise Price shall be equal to a number of shares
      of
      eXeg Common Stock determined by dividing the sum of US $10 million by the eXeg
      Share Price. eXeg Share Price shall be equal to the average per share closing
      price of eXeg Common Stock for the ten (10) trading days ended on the second
      business day prior to the exercise of the Option; provided, however, that
      notwithstanding the foregoing, the eXeg Share Price shall not exceed US $3.55
      nor be less than US $3.20. 

    

    
      
        
        

      

      
        11

        
          

        

      

      
        
        

      

    

    The
      Options shall be predicated on the understanding that:

    

    
      	
            	(a)	
              the
                share purchase transaction to be effected by the exercise of the
                Option
                shall be structured so as to be tax neutral to the Selling Shareholders
                and the Investor (which structure may include the transfer of shares
                through a Nova Scotia unlimited liability corporation, or such other
                mechanism as may be approved by the tax advisors of the parties;
                

            

    

    

    
      	
            	(b)	
              the
                Options shall be subject to compliance with applicable law in Ontario
                respecting shareholders’ rights; 

            

    

    

    
      	
            	(c)	
              the
                Company shall dedicate its best efforts to arranging for audits to
                be
                conducted in a timely fashion respecting the Company’s fiscal years 2006
                and 2007. The audits shall be prepared in accordance with generally
                accepted accounting principles in Canada (GAAP).
                

            

    

    

    6.2  Conduct
      of the Company Prior to the Option Closing Date.

    

    Unless
      the Investor otherwise agrees in writing and except as otherwise set forth
      in
      this Agreement, between the date of this Agreement and the closing or expiration
      of the Options (the “Option Closing Date”), the Company will: (i) conduct its
      business only in the ordinary course of business, (ii) use its reasonable
      efforts to keep available the services of its present officers and employees
      material to its business operations and (iii) use its reasonable efforts to
      preserve its current relationships with its customers, suppliers, distributors,
      licensors, officers and other key employees and other persons with which it
      has
      significant business relationships.

    

    
      
        	
              	(a)	
                Between
                  the date of this Agreement and the Option Closing Date, the Company
                  shall
                  confer with the Investor from time to time as reasonably requested
                  by the
                  Investor to discuss any material changes or developments in the
                  operational matters of the
                  Company.

              

      

    

    

    
      
        	
              	(b)	
                Except
                  as expressly provided in this Agreement, between the date of this
                  Agreement and the Option Closing Date, the Company will not do
                  any of the
                  following without the prior written consent of the Investor:

              

      

    

    

    
      	 	
              (i)

            	
              create
                any Lien on any of its properties or assets (whether tangible or
                intangible),

            

    

    

    
      	 	
              (ii)

            	
              sell,
                assign, transfer, lease or otherwise dispose of or agree to sell,
                assign,
                transfer, lease or otherwise dispose of any its fixed assets or cancel
                any
                indebtedness owed to it.

            

    

    

    
      	 	
              (iii)

            	
              change
                any method of accounting or accounting practice used by it, other
                than
                such changes required by GAAP.

            

    

    

    
      	 	
              (iv)

            	
              issue
                or sell any additional shares of the capital stock of, or other equity
                interests in it, or securities convertible into or exchangeable for
                such
                shares or equity interests, or issue or grant any options, warrants,
                calls, subscription rights or other rights of any kind to acquire
                additional shares of such capital stock, such other equity interests
                or
                such securities.

            

    

    

    
      
        
        

      

      
        12

        
          

        

      

      
        
        

      

    

    
      	 	
              (v)

            	
              amend
                the Company’s Articles.

            

    

    

    
      	 	
              (vi)

            	
              declare,
                set aside or pay any dividend or distribution with respect to any
                share of
                its capital stock or declare or effectuate a stock dividend, stock
                split
                or similar event.

            

      	 	 	 

      	 	(vii)	issue any note, bond, or other debt security or
              create,
              incur,  assume,
              or guarantee any indebtedness for borrowed money or capitalized lease
              obligation.

    

    

    
      	 	
              (viii)

            	
              make
                any capital investment in, make any loan to, or acquire the securities
                or
                assets of any other person or
                entity.

            

    

    

    
      	 	
              (ix)

            	
              enter
                into any new or additional agreements or materially modify any existing
                agreements relating to the employment of any officer or any written
                agreements of any of its employees, except in the ordinary course
                of
                business.

            

    

    

    
      	 	
              (x)

            	
              make
                any payments outside of the ordinary course of business to any of
                the its
                officers, directors, employees or stockholders. or
                

            

    

    

    
      	 	
              (xi)

            	
              agree
                to take any of the actions specified in this Section
                6.2.

            

    

    

    

    
      	7.	
              Miscellaneous

            

    

    

    
      
        
          	7.1	
                  Entire
                    Agreement.
                    This Agreement and the Schedules and Exhibits attached hereto
                    fully
                    embraces the legal relationship between the Parties, and no previous
                    agreements, memoranda of agreements, letters, negotiations, promises,
                    consents, undertakings, representations, warranties or documents
                    which
                    were applied, exchanged, or signed by or between any of the Parties
                    prior
                    to the signing of this Agreement shall have any force or effect
                    with
                    respect to the subject matter
                    hereof.

                

        

      

    

    

    
      	7.2	
              Survival.
                The representations, warranties, covenants and agreements made herein
                shall survive any investigation made by the Investor and the closing
                of
                the transactions contemplated hereby for a period of two years following
                the Closing. All statements as to factual matters contained in any
                certificate or other instrument delivered by or on behalf of the
                Company
                pursuant hereto in connection with the transactions contemplated
                hereby
                shall be deemed to be representations and warranties by the Company
                hereunder solely as of the date of such certificate or
                instrument.

            

    

    

    
      	7.3	
              Reports.
                Within
                90 (ninety) days after the end of each quarter and fiscal year, the
                Company shall deliver to the Investor a cop of: (i) a balance sheet
                of the
                Company as at the end of such period, and (ii) statement of income,
                consolidated statements of shareholders' equity and cash flows and
                consolidating schedule of investment activities for purchases of
                property
                and equipment of the Company for such period, all in reasonable detail,
                prepared in accordance with generally accepted accounting practices
                in
                Canada, consistently applied (“GAAP”), and fairly presenting, in all
                material respects, the financial position of the Company on and its
                results of operations and cash flows, subject to changes resulting
                from
                normal year-end adjustments that will not be material in amount or
                effect.
                In the case of the annual reports, such reports shall set forth in
                comparative form the figures for the prior fiscal year and the
                corresponding figures from the consolidated plan and financial forecast
                for the current fiscal year described below. As soon as practicable
                but in
                any event no later than the last day of each fiscal year, the Company
                shall deliver to the Investor a forecast and budget for each of the
                next
                succeeding 12 (twelve) months of the consolidated balance sheet and
                the
                statements of income, cash flows and stockholders' equity of the
                Company
                together with an outline of the major assumptions upon which the
                forecast
                is based. 

            

    

    

    
      
        
        

      

      
        13

        
          

        

      

      
        
        

      

    

    
      	7.4	
              Successors
                and Assigns.
                The Company shall not sell, assign, transfer, or otherwise convey
                any of
                its rights or delegate any of its duties under this Agreement, except
                to a
                company which has succeeded to substantially all of the business
                and
                assets of the Company in compliance with this Agreement and has assumed
                in
                writing its obligations under this Agreement. Except as otherwise
                provided
                herein, the terms and conditions of this Agreement shall inure to
                the
                benefit of and be binding upon the respective successors, assigns,
                executors and administrators of the Parties. Nothing in this Agreement,
                express or implied, is intended to confer upon any party other than
                the
                Parties or their respective successors and permitted assigns any
                rights,
                obligations, or liabilities under or by reason of this
                Agreement.

            

    

     

    
      	7.5	
              Governing
                Law; Jurisdiction.
                This Agreement shall be governed by and construed according to the
                laws of
                the State of Florida, without regard to the conflict of laws provisions
                thereof. 

            

    

    

    
      	7.6	
              Severability.
                If one or more provisions of this Agreement is held to be illegal,
                invalid
                or unenforceable under applicable law, such provision shall be excluded
                from this Agreement, and the balance of the Agreement shall be interpreted
                as if such provision were so excluded and shall be enforceable in
                accordance with its terms; provided, however, that in such event
                this
                Agreement shall be interpreted so as to give effect, to the greatest
                extent consistent with and permitted by applicable law, to the meaning
                and
                intention of the excluded provision as determined by such court of
                competent jurisdiction.

            

    

    

    
      	7.7	
              Amendment
                and Waiver.
                The
                failure of any Party at any time or times to require performance
                of any
                provision hereof or to enforce any right with respect thereto, shall
                in no
                manner affect the right of such Party at a later time to enforce
                the same
                and shall in no way be construed to be a waiver of such provision
                or
                right.
                Any term of this Agreement may be amended only with the written consent
                of
                the Company and the Investor.

            

    

    

    
      	7.8	
              Delays
                or Omissions.
                It is agreed that no delay or omission to exercise any right, power
                or
                remedy accruing to any party, upon any breach, default or non-compliance
                by another party under this Agreement, or the Articles, shall impair
                any
                such right, power or remedy, nor shall it be construed to be a waiver
                of
                any such breach, default or non-compliance, or any acquiescence therein,
                or of or in any similar breach, default or non-compliance thereafter
                occurring. It is further agreed that any waiver, permit, consent
                or
                approval of any kind or character on the Investor’s part of any breach,
                default, or non-compliance under this Agreement, or under the Articles
                or
                any waiver on such party’s part of any provisions or conditions of the
                Agreement or Articles must be in writing and shall be effective only
                to
                the extent specifically set forth in such writing. All remedies,
                either
                under this Agreement, the Articles, by law, or otherwise afforded
                to any
                party, shall be cumulative and not alternative.

            

    

    

    
      
        
        

      

      
        14

        
          

        

      

      
        
        

      

    

    
      	7.9	
              Notices.
                All notices required or permitted hereunder shall be in writing and
                shall
                be deemed effectively given: (a) upon personal delivery to the party
                to be
                notified, (b) when sent by confirmed telex or facsimile if sent during
                normal business hours of the recipient, if not, then on the next
                business
                day, (c) three (3) business days after having been sent by registered
                or
                certified mail, return receipt requested, postage prepaid, or (d)
                one (1)
                business day after deposit with a nationally recognized overnight
                courier,
                specifying next day delivery, with written verification of receipt.
                All
                communications shall be sent to the Company and to the Investor at
                their
                respective addresses as set forth on the signature page hereof or
                at such
                other address as the Company or Investor may designate by written
                notice
                to the other parties hereto. 

            

    

    

    
      	7.10	
              Expenses.
                The Company shall pay all costs and expenses that it incurs with
                respect
                to the negotiation, execution, delivery and performance of the Agreement,
                including the reasonable fees and disbursements of counsel to the
                Investor, which fees and disbursements shall not exceed
                $40,000.
                

            

    

    

    
      	7.11	
              Titles
                and Subtitles.
                The titles of the sections and subsections of the Agreement are for
                convenience of reference only and are not to be considered in construing
                this Agreement. 

            

    

    

    
      	7.12	
              Counterparts
                and Facsimile Signature.
                This Agreement may be executed in any number of counterparts and
                by means
                of facsimile signature, each of which shall be an original, but all
                of
                which together shall constitute one
                instrument.

            

    

    

    
      	7.13	
              Confidentiality.
                The parties hereto agree that, except with the prior written consent
                of
                the Company, it shall at all times keep confidential and not divulge,
                furnish or make accessible to anyone any confidential information,
                knowledge or data concerning or relating to the business or financial
                affairs of the Company to which the Investor has been or shall become
                privy by reason of this Agreement, discussions or negotiations relating
                to
                this Agreement, the performance of its obligations hereunder or the
                ownership of the Shares purchased hereunder. The provisions of this
                Section shall be in addition to, and not in substitution for, the
                provisions of any separate non-disclosure agreement which may have
                been
                executed by the parties hereto. 

            

    

    

    
      	7.14	
              Pronouns.
                All pronouns contained herein, and any variations thereof, shall
                be deemed
                to refer to the masculine, feminine or neutral, singular or plural,
                as to
                the identity of the parties hereto may require.

            

    

    

    
      	7.15	
              Further
                Assurances. From
                time to time after the Closing Date, each party shall, at the request
                of
                the other party, execute and deliver such additional conveyances,
                transfers and other assurances as may be reasonably required to
                effectively transfer the Shares to the Investor and the adjustments
                provided for in subsection 1.4 hereof and otherwise to carry out
                the
                intent of this Agreement.

            

    

    

    [The
      remainder of this page intentionally left blank]

     

    
      
        
        

      

      
        15

        
          

        

      

      
        
        

      

    

     

    In
      Witness Whereof,
      the
      parties have executed this Share
      Purchase Agreement
      as of
      the date set forth in the first paragraph hereof. 

    

    

    
      	
              Ophthalmic
                Technologies Inc.

               

              By:
                _______________________________

              Name:
                _____________________________

               

              Address:

              37
                Kodiak Crescent,

              Unit
                16

              Toronto,
                Ontario M3J 3E5

              CANADA

              Fax:
                (416) 631-6932

            	 	
              Exegenics
                Inc.

               

              By:
                _______________________________

              Name:
                _____________________________

               

              Address:

               

               

              Fax:
                

            

    

    

     

    The
      following constitute the Selling Shareholders referenced in Article 6 hereof
      and, by their execution below, agree to the provisions of Article
      6.

     

    
      	 	 	
              1161983
                ONTARIO LIMITED

            
	 	 	
              Per:

            	 
	 	 	 	
              Name:
                

            
	 	 	 	
              Title:
                

            

    

    

     

    

     

    
      	 	 	
              GRALL
                CORPORATION LIMITED

            
	 	 	
              Per:

            	 
	 	 	 	
              Name:
                

            
	 	 	 	
              Title:
                

            

    

    

     

    
      	 	 	 
	
              Witness
                Name:

            	
              Rishard
                Weitz

            
	 	 
	 	 	 
	
              Witness
                Name:

            	
              Carolyn
                Weiss

            

    

    

     

    
      	 	 	 
	
              Witness
                Name:

            	
              Gerald
                Weiss

            

    

    

     

    
      
        
        

      

      
        16SHARE
      PURCHASE AGREEMENT

     

     

    November
      28, 2007

     

     

    

      
        	
                ARTICLE
                  1 INTERPRETATION

              	
                2

              
	
                1.1

              	
                DEFINITIONS

              	
                2

              
	
                1.2

              	
                RULES
                  OF INTERPRETATION

              	
                6

              
	
                IN
                  THIS AGREEMENT:

              	
                6

              
	
                1.3

              	
                ENTIRE
                  AGREEMENT

              	
                7

              
	
                1.4

              	
                TERMINATION

              	
                7

              
	
                ARTICLE
                  2 PURCHASE AND SALE OF SHARES

              	
                7

              
	
                2.1

              	
                PURCHASE
                  AND SALE OF SHARES

              	
                7

              
	
                2.2

              	
                PAYMENT
                  OF PURCHASE PRICE

              	
                7

              
	
                2.3

              	
                ESCROW

              	
                7

              
	
                ARTICLE
                  3 REPRESENTATIONS AND WARRANTIES

              	
                8

              
	
                3.1

              	
                REPRESENTATIONS
                  AND WARRANTIES OF THE SELLERS

              	
                8

              
	
                3.1.1

              	
                ORGANIZATION
                  AND QUALIFICATION OF THE CORPORATION

              	
                8

              
	
                3.1.2

              	
                ORGANIZATION
                  AND QUALIFICATION OF THE SELLERS

              	
                8

              
	
                3.1.3

              	
                SUBSIDIARIES

              	
                8

              
	
                3.1.4

              	
                CAPITALIZATION
                  AND TITLE

              	
                8

              
	
                3.1.5

              	
                AUTHORIZATION
                  OF THE CORPORATION

              	
                9

              
	
                3.1.6

              	
                AUTHORIZATION
                  OF THE SELLERS

              	
                9

              
	
                3.1.7

              	
                FINANCIAL
                  STATEMENTS

              	
                9

              
	
                3.1.8

              	
                LIABILITIES

              	
                10

              
	
                3.1.9

              	
                AGREEMENTS
                  AND ACTIONS

              	
                10

              
	
                3.1.10

              	
                OBLIGATIONS
                  TO RELATED PARTIES

              	
                10

              
	
                3.1.11

              	
                CHANGES

              	
                10

              
	
                3.1.12

              	
                TITLE
                  TO PROPERTIES AND ASSETS; LIENS, ETC.

              	
                11

              
	
                3.1.13

              	
                INTELLECTUAL
                  PROPERTY

              	
                11

              
	
                3.1.14

              	
                COMPLIANCE
                  WITH OTHER INSTRUMENTS- CORPORATION.

              	
                12

              
	
                3.1.15

              	
                COMPLIANCE
                  WITH OTHER INSTRUMENTS-SELLERS.

              	
                12

              
	
                3.1.16

              	
                LITIGATION

              	
                12

              
	
                3.1.17

              	
                TAX
                  RETURNS AND PAYMENTS

              	
                13

              
	
                3.1.18

              	
                EMPLOYEES

              	
                13

              
	
                3.1.19

              	
                OBLIGATIONS
                  OF KEY EMPLOYEES

              	
                13

              
	
                3.1.20

              	
                REGISTRATION
                  RIGHTS AND VOTING RIGHTS

              	
                13

              
	
                3.1.21

              	
                COMPLIANCE
                  WITH LAWS; PERMITS

              	
                13

              
	
                3.1.22

              	
                FULL
                  DISCLOSURE

              	
                14

              
	
                3.1.23

              	
                INSURANCE

              	
                14

              
	
                3.1.24

              	
                SECURITIES
                  LEGISLATION

              	
                14

              
	
                3.1.25

              	
                SECTION
                  6.2 OF THE SHARE PURCHASE AGREEMENT

              	
                14

              
	
                3.1.26

              	
                ACKNOWLEDGEMENT
                  OF EXCHANGE AGREEMENT

              	
                14

              
	
                3.2

              	
                REPRESENTATIONS
                  AND WARRANTIES OF THE BUYER

              	
                14

              
	
                3.2.1

              	
                ORGANIZATION
                  AND QUALIFICATION

              	
                14

              
	
                3.2.2

              	
                SUBSIDIARIES

              	
                15

              
	
                3.2.3

              	
                CAPITALIZATION
                  OF THE BUYER

              	
                15

              
	
                3.2.4

              	
                CAPITALIZATION
                  OF THE HOLDCO

              	
                15

              
	
                3.3

              	
                NON-WAIVER/SCHEDULE
                  OF EXCEPTIONS

              	
                15

              
	
                3.3.1

              	
                NON-WAIVER

              	
                15

              
	
                3.3.2

              	
                SCHEDULE
                  OF EXCEPTIONS

              	
                15

              

      

       

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

      
        	
                3.4

              	
                TAX
                  COVENANTS

              	
                15

              
	
                3.5

              	
                SURVIVAL
                  OF REPRESENTATIONS AND WARRANTIES

              	
                16

              
	
                3.6

              	
                KNOWLEDGE
                  OF THE SELLERS

              	
                16

              
	
                ARTICLE
                  4 NON-SOLICITATION AND NON-COMPETE

              	
                17

              
	
                4.1

              	
                NON
                  - COMPETITION

              	
                17

              
	
                4.2

              	
                NON
                  -SOLICITATION OF EMPLOYEES OR CONSULTANT.

              	
                17

              
	
                4.3

              	
                NON-SOLICITATION
                  OF CLIENTS.

              	
                17

              
	
                4.4

              	
                RESTRICTIONS
                  REASONABLE

              	
                17

              
	
                4.5

              	
                INJUNCTIVE
                  RELIEF

              	
                18

              
	
                ARTICLE
                  5 INDEMNIFICATION

              	
                18

              
	
                5.1

              	
                INDEMNIFICATION
                  BY THE SELLERS

              	
                18

              
	
                5.2

              	
                INDEMNIFICATION
                  BY THE BUYER

              	
                19

              
	
                5.3

              	
                DEFENCE
                  OF CLAIMS

              	
                19

              
	
                ARTICLE
                  6

              	
                20

              
	
                6.1

              	
                CLOSING
                  DELIVERIES OF THE SELLER

              	
                20

              
	
                6.2

              	
                CLOSING
                  DELIVERIES OF THE BUYER

              	
                21

              
	
                6.3

              	
                PAYMENT
                  OF SHAREHOLDER AND RELATED PARTY LOANS

              	
                22

              
	
                6.4

              	
                CLOSING
                  PAYMENTS

              	
                22

              
	
                ARTICLE
                  7 GENERAL

              	
                22

              
	
                7.1

              	
                EXPENSES

              	
                22

              
	
                7.2

              	
                ENUREMENT

              	
                22

              
	
                7.3

              	
                NOTICES
                  TO PARTIES

              	
                22

              
	
                7.4

              	
                AMENDMENT

              	
                25

              
	
                7.5

              	
                ASSIGNMENT

              	
                25

              
	
                7.6

              	
                FURTHER
                  ASSURANCES

              	
                25

              
	
                7.7

              	
                PUBLIC
                  ANNOUNCEMENTS

              	
                25

              
	
                7.8

              	
                REMEDIES
                  CUMULATIVE

              	
                25

              
	
                7.9

              	
                LIMITATION
                  OF LIABILITY

              	
                25

              
	
                7.10

              	
                EXECUTION
                  AND DELIVERY

              	
                26

              

      

       

       

    

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    SHARE
      PURCHASE AGREEMENT

     

    THIS
      AGREEMENT made as of the 28th
      day of
November,
      2007,

     

    BETWEEN:

     

    Ophthalmic
      Technologies Inc.

    a
      corporation incorporated under the laws of Ontario

     

    (
      the
      "Corporation")

     

    -
      and
      -

     

    OTI
      Holdings Limited

    a
      corporation incorporated under the laws of Ontario

     

    (the
      "Buyer" or “Newco”)

     

    -
      and
      -

     

    1161983
      Ontario Limited, 

    a
      corporation incorporated under the laws of Ontario

     

    ("1161983")

     

    -
      and
      -

     

    Grall
      Corporation Limited, 

    a
      corporation incorporated under the laws of Ontario

     

    ("Grall")

     

    -
      and
      -

     

    Triple
      Net Properties Limited 

    a
      corporation incorporated under the laws of Ontario

     

    (“3Net”)

     

    -
      and
      -

     

    Rishard
      Weitz

     

    ("Weitz")

     

    -
      and
      -

     

    Carolyn
      Weiss

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    ("Weiss")

     

    -
      and
      -

     

    Shane
      Dunne 

     

    ("Dunne")

     

    -
      and
      -

     

    Gerald
      Weiss, in trust for Marie-Helene Weiss and Gerald Weiss

     

    ("Gerald")

     

    -
      and -

     

    Gerald
      Weiss

     

     

    

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

     

    RECITALS:

     

    
      	
              1.

            	
              On
                April 11, 2007, Exegenics Inc. entered into a share purchase agreement
                with the Corporation (the "Share Purchase Agreement") pursuant to
                which it
                was granted an option to purchase shares of the Corporation from
                1161983,
                Grall, Weitz, Weiss, and Gerald and pursuant to which the Corporation
                undertook to dedicate its best efforts to procure options from the
                other
                shareholders of the Corporation who had not already granted such
                options.

            
	 	 
	
              2.

            	
              Opko
                Health, Inc. (“Opko”), a Delaware Corporation is the successor to
                Exegenics Inc.

            
	 	 
	
              3.

            	
              On
                November 9, 2007, Opko incorporated a wholly owned subsidiary, Ophthalmic
                Technologies Holdings Limited (“Holdco”).

            
	 	 
	
              4.

            	
              On
                November 9, 2007, Holdco incorporated a wholly owned subsidiary,
                Newco for
                the purpose of implementing the exercise of the Option.

            
	 	 
	
              5.

            	
              1161983,
                Grall, 3Net, Weitz, Weiss, Dunne and Gerald (collectively, the "Sellers"
                and each a "Seller"), are, as of the date hereof, the legal and beneficial
                owner of all of the issued and outstanding shares of the Corporation,
                other than the shares of the Corporation held by Opko Inc. in accordance
                with the Capitalization Table attached as Schedule "A" hereto.
                

            
	 	 
	
              6.

            	
              The
                Buyer wishes to purchase all, but not less than all, of the issued
                and
                outstanding shares of the Corporation held by the Sellers and each
                Seller
                wishes to sell all, but not less than all, of the issued and outstanding
                shares of the Corporation such Seller holds.

            
	 	 
	
              7.

            	
              Opko,
                the Buyer and the Seller are parties to that certain Exchange and
                Support
                Agreement of even date (the “Exchange
                Agreement”).

            

    

     

    IN
      CONSIDERATION
      of the
      premises and the mutual agreements in this Agreement, and of other consideration
      (the receipt and sufficiency of which are acknowledged by each of the Parties),
      the Parties agree as follows:

     

    ARTICLE
      1

    INTERPRETATION

     

    
      	
              1.1

            	
              Definitions

            

    

     

    In
      this
      Agreement,

     

    “Affiliate”
      means,
      with respect to any Person, (i) any other Person directly or indirectly
      controlling, controlled by, or under common control with such Person, (ii)
      any
      Person owning or controlling ten percent or more of the outstanding voting
      interests of such Person, (iii) any officer, director, or general partner of
      such Person, (iv) any family member of such Person or any trust, family limited
      partnership or other similar entity controlled by such Person or his or her
      family members, or (v) any Person who is an officer, director, general partner,
      trustee, or holder of ten percent or more of the voting interests of any Person
      described in clauses (i) through (iv). For purposes of this definition, the
      terms “controlling”,
      “controlled
      by,”
or
      “under
      common control with”
shall
      mean the possession, direct or indirect, of the power to direct or cause the
      direction of the management and policies of a Person, whether through the
      ownership of voting securities, by contract or otherwise;

     

    
      
        
        

      

      
        -2-

        
          

        

      

      
        
        

      

    

    “Agreement”
      means
      this agreement, including all schedules, and all amendments or restatements
      as
      permitted, and references to “Article”,
      “Section”
or
      “Schedule”
mean
      the specified Article, Section or Schedule of this Agreement;

     

    "Articles"
      means
      the articles of incorporation of the Corporation dated April 16, 1993, and
      as
      may be amended or restated from time to time;

     

    "Business"
      means
      the business of providing ophthalmic ultrasound and optical coherence tomography
      (OCT) equipment for ophthalmology;

     

    “Business
      Day”
means
      any day except a Saturday, Sunday or any day on which banks are generally not
      open for business in either of the Cities of Toronto, Ontario and New York,
      New
      York;

     

    “Canadian
      Dollar Equivalent”
means,
      in respect of an amount expressed in a currency other than Canadian dollars
      (the
“Foreign
      Currency Amount”)
      at any
      date, the product obtained by multiplying: 

     

    (A)
      the
      Foreign Currency Amount; by

     

    (B)
      the
      noon spot exchange rate on such date for such foreign currency expressed in
      Canadian dollars as reported by the Bank of Canada or, if such spot exchange
      rate is not available, such exchange rate on such date for such foreign currency
      expressed in Canadian dollars as may be deemed by the Board of Directors in
      good
      faith to be appropriate for such purpose. 

     

    "Claim"
      means
      any demand, action, suit, proceeding, claim, assessment, judgment or settlement
      or compromise relating thereto which may give rise to a right to
      indemnification;

     

    "Closing"
      means
      the completion of the sale to, and purchase by, the Buyer of the Shares on
      the
      date hereof and the completion of all other transactions contemplated by this
      Agreement which are to occur contemporaneously with the purchase and sale of
      the
      Shares;

     

    "Closing
      Document"
      means
      any document delivered at or subsequent to the Closing as provided in or
      pursuant to, this Agreement;

     

    "Competitive
      Business"
      means
      the business of any Person that is similar to or competes with the
      Business;

     

    
      
        
        

      

      
        -3-

        
          

        

      

      
        
        

      

    

    "Corporation"
      means
      Ophthalmic Technologies Inc.;

     

    “Dunne
      Escrow Shares”
means
      10,323.94 Exchangeable Shares;

     

    "Employment
      Contracts"
      means
      employment agreements with the Key Employees to be delivered as a condition
      precedent to Closing;

     

    "Escrow
      Shares" has
      the
      meaning set out in Section 2.3;

     

    “Exchangeable
      Shares”
means
      the exchangeable shares in the capital of the Buyer;

     

    “Financial
      Statements”
means
      the financial statements set out in Section 3.1.7
      hereto;

     

    “Financial
      Statement Date”
means
      April 30, 2007;

     

    "including"
      means
      "including
      without limitation''
      and the
      term "including"
      shall
      not be construed to limit any general statement which it follows to the specific
      or similar items or matters immediately following it;

     

    “Law”
means
      any federal, state, provincial, municipal, local or foreign statute, law,
      by-law, ordinance, regulation, rule, code, order or rule of or duty under common
      law, including any statute, law, by-law, ordinance, regulation, rule, code,
      order or rule of or duty under common law in Canada, the United States, any
      province or territory of Canada or any state or territory of the United
      States.

     

    "Loss"
      and
      "Losses"
      have
      the meaning set out in ARTICLE
      5;

     

    "ordinary
      course"
      when
      used in relation to the conduct of the Business means any transaction which
      constitutes an ordinary day-to-day business activity of the Corporation
      conducted in a commercially reasonable and businesslike manner consistent with
      the Corporation's past practices;

     

    "Parties"
      means
      the Buyer and the Sellers, collectively, and "Party" means any one of
      them;

     

    “Person”
means
      any individual, sole proprietorship, partnership, firm, entity, unincorporated
      association, unincorporated syndicate, unincorporated organization, trust,
      body
      corporate, government, government regulatory authority, governmental department,
      agency, commission, board, tribunal, dispute settlement panel or body, bureau
      or
      court, and where the context requires, any of the above when they are acting
      as
      trustee, executor, administrator or other legal representative;

     

    "Purchase
      Price"
      shall
      be equal to the number of Exchangeable Shares granted to all of the Sellers
      pursuant to Section 2.2
      multiplied by US$3.55;

     

    "Representative"
      means
      each director, officer, employee, agent, solicitor, accountant, professional
      advisor and other representative of an Indemnified Party;

     

    
      
        
        

      

      
        -4-

        
          

        

      

      
        
        

      

    

    "Restricted
      Period"
      means
      the later of the last day of:

     

    (i)
      the
      period commencing on the Closing and ending 3 years after the Closing; and
      

     

    (ii)

     

    (a)
      if
      Weitz or Gerald Weiss ceases to be an employee of the Corporation at any time
      during the first three years following the Closing, the period commencing on
      the
      date Weitz or Gerald Weiss, as the case may be, ceases to be an employee of
      the
      Corporation and ending 2 years after such date; and

     

    (b) if
      Weitz
      or Gerald Weiss ceases to be an employee of the Corporation at any time after
      the first three years following the date of Closing, the period commencing
      on
      the date Weitz or Gerald Weiss, as the case may be, ceases to be an employee
      of
      the Corporation and ending 6 months after such date, provided that the
      restricted period may be extended by the Corporation for a further 18 months
      in
      accordance with the terms of the non-competition agreement dated as of the
      date
      hereof, between Rishard Weitz or Gerald Weiss, as the case may be and the
      Corporation.

     

    “Schedule
      of Exceptions”
means
      the schedule so named and attached to this Agreement.

     

    "Tax"
      and
      "Taxes"
      mean,
      with respect to any Person:

     

    
      	 	
              (a)

            	
              all
                income taxes (including any tax on or based upon net income, gross
                income,
                income as specially defined, earnings, profits or selected items
                of
                income) and all capital taxes, gross receipts taxes, environmental
                taxes,
                sales taxes, use taxes, ad valorem taxes, value added taxes, transfer
                taxes, franchise taxes, licence taxes, withholding taxes, payroll
                taxes,
                employment taxes, Canada Pension Plan premiums, excise, severance,
                social
                security premiums, workers' compensation premiums, employment insurance
                or
                compensation premiums, stamp taxes, occupation taxes, premium taxes,
                property taxes, windfall profits taxes, alternative or add-on minimum
                taxes, goods and services tax, customs duties or other taxes, fees,
                imposts, assessments or charges of any kind whatsoever, together
                with any
                interest and any penalties or additional amounts imposed by any taxing
                authority (domestic or foreign) on such Person, and any interest,
                penalties, additional taxes and additions to tax imposed with respect
                to
                the foregoing; and

            

    

     

    
      	 	
              (b)

            	
              any
                liability for the payment of any amount of the type described in
                the
                immediately preceding subsection (a) of another
                Person.

            

    

     

    
      
        
        

      

      
        -5-

        
          

        

      

      
        
        

      

    

    
      	
              1.2

            	
              Rules
                of Interpretation

            

    

     

    In
      this
      Agreement:

     

    
      	 	
              (a)

            	
              Consent
                -
                Whenever a provision of this Agreement requires an approval or consent
                and
                such approval or consent is not delivered within the applicable time
                limit, then, unless otherwise specified, the Party whose consent
                or
                approval is required will be conclusively deemed to have withheld
                its
                approval or consent.

            

    

     

    
      	 	
              (b)

            	
              Currency
                -
                Unless otherwise specified, all references to money amounts are to
                the
                lawful currency of the United States of
                America.

            

    

     

    
      	 	
              (c)

            	
              Governing
                Law
                -
                This Agreement is a contract made under and is governed by and construed
                in accordance with the law of the Province of Ontario and the federal
                laws
                of Canada applicable in the Province of
                Ontario.

            

    

     

    
      	 	
              (d)

            	
              Headings
                -
                Headings of Articles and Sections are inserted for convenience of
                reference only and do not affect the construction or interpretation
                of
                this Agreement.

            

    

     

    
      	 	
              (e)

            	
              Number
                and Gender
                -
                Unless the context otherwise requires, words importing the singular
                include the plural and vice versa and words importing gender include
                all
                genders.

            

    

     

    
      	 	
              (f)

            	
              Severability
                -
                If, in any jurisdiction, any provision of this Agreement or its
                application to any party or circumstance is restricted, prohibited
                or
                unenforceable, such provision will, as to such jurisdiction, be
                ineffective only to the extent of such restriction, prohibition or
                unenforceability without invalidating the remaining provisions of
                this
                Agreement and without affecting the validity or enforceability of
                such
                provision in any other jurisdiction or without affecting its application
                to other Parties or circumstances.

            

    

     

    
      	 	
              (g)

            	
              Statutory
                references
                -
                A reference to a statute includes all regulations made pursuant to
                such
                statute and, unless otherwise specified, the provisions of any statute
                or
                regulation that amends, supplements or supersedes any such statute
                or any
                such regulation.

            

    

     

    
      	 	
              (h)

            	
              Time
                -
                Time is of the essence in the performance of the Parties’ respective
                obligations.

            

    

     

    
      	 	
              (i)

            	
              Time
                Periods
                -
                Unless otherwise specified, time periods within or following which
                any
                payment is to be made or act is to be done are calculated by excluding
                the
                day on which the period commences and including the day on which
                the
                period ends and by extending the period to the next Business Day
                if the
                last day of the period is not a Business
                Day.

            

    

     

    
      
        
        

      

      
        -6-

        
          

        

      

      
        
        

      

    

    
      	
              1.3

            	
              Entire
                Agreement

            

    

     

    This
      Agreement together with the Share Purchase Agreement, the Exchangeable Share
      Provisions, the Exchange and Support Agreement and the documents delivered
      pursuant to such agreements constitutes the entire agreement between the Parties
      and sets out all the covenants, promises, warranties, representations,
      conditions, understandings and agreements between the Parties pertaining to
      the
      subject matter of this Agreement and supersedes all prior agreements,
      understandings, negotiations and discussions, whether oral or written. There
      are
      no covenants, promises, warranties, representations, conditions, understandings
      or other agreements, oral or written, express, implied or collateral between
      the
      Parties in connection with the subject matter of this Agreement except as
      specifically set forth in this Agreement and the Exchangeable Share
      Provisions.

     

    
      	
              1.4

            	
              Termination

            

    

     

    Section
      6
      of the Share Purchase Agreement is hereby terminated and is of not further
      force
      or effect.

     

    ARTICLE
      2

    PURCHASE
      AND SALE OF SHARES

     

    
      	
              2.1

            	
              Purchase
                and Sale of Shares

            

    

     

    The
      Buyer
      agrees to purchase the Shares for the Purchase Price and Sellers agrees to
      sell
      and transfer the Shares to the Buyer for the Purchase Price.

     

    
      	
              2.2

            	
              Payment
                of Purchase Price

            

    

     

    The
      Purchase Price shall be paid to each Seller by issuing to such Seller on the
      date hereof such number of Exchangeable Shares as is equal to the number of
      shares of the Corporation owned by such Seller multiplied by
      20,730.80 On
      the
      date hereof, the
      Buyer, the Seller and Opko shall deliver an Exchange and Support Agreement
      with
      respect to such Exchangeable Shares. 

     

    
      	
              2.3

            	
              Escrow

            

    

     

    As
      security for the obligations of the Sellers, under ARTICLE
      5,
      on the
      date hereof, each Seller shall direct that 15% of the Exchangeable Shares issued
      to such Seller in satisfaction of the Purchase Price shall be deposited with
      Fraser, Milner, Casgrain LLP as escrow agent (the "Escrow
      Agent"),
      who
      shall hold such shares (collectively, the "Escrow
      Shares")
      pursuant to the terms of an agreement substantially in the form attached hereto
      as Schedule 2.3
      hereto
      (the "Escrow
      Agreement").

     

    
      
        
        

      

      
        -7-

        
          

        

      

      
        
        

      

    

     

    ARTICLE
      3

    REPRESENTATIONS
      AND WARRANTIES

     

    
      	
              3.1

            	
              Representations
                and Warranties of the
                Sellers

            

    

     

    Other
      than with respect to Shane Dunne whose representations shall be deemed to be
      several and separate and not joint and several, Sections 3.1.2
      (Organization and Qualification of the Sellers), 3.1.4(b)
      (Title),
3.1.6
      (Authorization of the Sellers), and 3.1.15
      (Compliance with other instruments-Sellers) which representations shall be
      deemed to be several and separate and not joint and several, the Sellers jointly
      and severally, represent and warrant to the Buyer as set out in the following
      Subsections of this Section and acknowledge that the Buyer is relying upon
      such
      representations and warranties in entering into this Agreement.

     

    
      	
              3.1.1

            	
              Organization
                and Qualification of the
                Corporation

            

    

     

    The
      Corporation is duly organized and validly existing under the laws of Ontario,
      Canada. The Corporation has all requisite corporate power and authority to
      own
      and operate its properties and assets, to issue shares, and to carry out the
      provisions of this Agreement and to carry on its business as presently
      conducted.

     

    
      	
              3.1.2

            	
              Organization
                and Qualification of the
                Sellers

            

    

     

    Each
      Seller that is a Corporation is a duly organized and validly existing under
      the
      laws of Ontario, Canada. Each Seller that is a Corporation has all requisite
      corporate power and authority to own and operate its properties and assets,
      to
      issue shares, and to carry out the provisions of this Agreement and to carry
      on
      its business as presently conducted.

     

    
      	
              3.1.3

            	
              Subsidiaries

            

    

     

    Save
      and
      except as disclosed in the Schedule of Exceptions, the Corporation does not
      own
      or control any equity, security or other interest of any other corporation,
      limited partnership or other business entity.

     

    
      	
              3.1.4

            	
              Capitalization
                and Title

            

    

     

    
      	 	
              (a)

            	
              The
                authorized share capital of the Corporation consists of an unlimited
                number of shares of Common Stock with no par value ("Common
                Stock"),
                of which 200.42 shares are issued and outstanding in accordance with
                the
                Capitalization Table set out in Schedule "A" hereto (the “Capitalization
                Table”).
                All such Shares have been issued as fully paid and non-assessable.
                

            

    

     

    
      	 	
              (b)

            	
              Each
                Seller is the registered and beneficial owner of the Common Stock
                set out
                opposite such Sellers name on the Capitalization Table (collectively,
                the
                “Purchased
                Shares”)
                and has good and marketable title thereto. On Closing, the Buyer
                will
                acquire good and marketable title to the Purchased Shares. There
                are no
                restrictions on transfer of the Purchased Shares other than pursuant
                to
                the Articles of the Corporation.

            

    

     

    
      
        
        

      

      
        -8-

        
          

        

      

      
        
        

      

    

    
      	 	
              (c)

            	
              Except
                for the option to Justin Pedro, as disclosed in the Financial Statements,
                there are no outstanding options, warrants, rights (including conversion
                or pre-emptive rights and rights of first refusal), proxy or shareholder
                agreements, or agreements of any kind for the purchase or acquisition
                of
                any of the securities of the
                Corporation.

            

    

     

    
      	 	
              (d)

            	
              All
                issued and outstanding shares of the Corporation's Common Stock (i)
                have
                been duly authorized and validly issued and are fully paid and
                non-assessable, (ii) were issued in compliance with all applicable
                Canadian laws concerning the issuance of such securities and (iii)
                are
                free and clear of any liens or encumbrances, provided, however, that
                such
                shares may be subject to restrictions on transfer under U.S., Canadian
                or
                any applicable state or provincial securities laws as set forth herein,
                or
                as otherwise required by such laws of the time the transfer is
                proposed.

            

    

     

    
      	
              3.1.5

            	
              Authorization
                of the Corporation

            

    

     

    The
      Corporation has the full power and authority to execute, enter into and perform
      its obligations under this Agreement. In the case of the Corporation this
      Agreement has been duly authorized by all of the necessary corporate actions.
      This Agreement constitutes valid and legally binding obligations of the
      Corporation enforceable against it in accordance with its terms, all except
      as
      may be limited by applicable bankruptcy, insolvency, reorganization, moratorium,
      fraudulent conveyance, and other laws of general application affecting
      enforcement of creditors' rights generally, and as limited by laws relating
      to
      the availability of specific performance, injunctive relief or other equitable
      remedies.

     

    
      	
              3.1.6

            	
              Authorization
                of the Sellers

            

    

     

    Each
      Seller has the full power and authority to execute, enter into and perform
      its
      obligations under this Agreement. In the case of each Seller who is a
      Corporation, this Agreement has been duly authorized by all of the necessary
      corporate actions. This Agreement constitutes valid and legally binding
      obligations of each Seller, enforceable against such Seller in accordance with
      its terms, all except as may be limited by applicable bankruptcy, insolvency,
      reorganization, moratorium, fraudulent conveyance, and other laws of general
      application affecting enforcement of creditors' rights generally, and as limited
      by laws relating to the availability of specific performance, injunctive relief
      or other equitable remedies.

     

    
      	
              3.1.7

            	
              Financial
                Statements

            

    

     

    Except
      as
      set forth in the Schedule of Exceptions, the Audited financial statement of
      the
      Corporation for the period ended April 30, 2006 and April 30, 2007 and the
      unaudited financial statements for the period ended June 30, 2007, copies of
      which have been delivered to the Buyer and are attached hereto as Schedule
      3.1.7, together with the notes thereto, are complete and correct in all material
      respect, have been prepared in accordance with generally accepted accounting
      principles in the United States, applied on a consistent basis throughout the
      periods indicated and fairly present the financial condition and results of
      operations of the Corporation as of the respective dates thereof and for the
      respective periods indicated therein. 

     

    
      
        
        

      

      
        -9-

        
          

        

      

      
        
        

      

    

    
      	
              3.1.8

            	
              Liabilities

            

    

     

    Except
      as
      set forth in Schedule of Exceptions and the Financial Statements, the
      Corporation has no debts and, to the best of its knowledge, knows of no
      contingent debts, not disclosed in the financial statements, except current
      debts incurred in the ordinary course if business which have not been, either
      in
      any individual case or in the aggregate, materially adverse.

     

    
      	
              3.1.9

            	
              Agreements
                and Actions

            

    

     

    Except
      as
      set forth in the Schedule of Exceptions, (i) there are no judgments, orders,
      writs or decrees to which the Corporation is a party or to its knowledge by
      which it is bound (ii) there are no agreements, instruments, contracts or
      proposed transactions, which may involve (a) obligations (contingent or
      otherwise) of, or payments to, the Corporation in excess of $15,000, or (b)
      the
      transfer or license of any patent, copyright, trade secret or other proprietary
      right to or from the Corporation (other than licenses arising from the purchase
      of "off the shelf" or other standard products).

     

    
      	
              3.1.10

            	
              Obligations
                to Related Parties

            

    

     

    Except
      as
      set forth in the Schedule of Exceptions or the Financial Statements, there
      are
      no obligations of the Corporation to officers, directors, shareholders, or
      employees of the Corporation other than (a) for payment of salary for services
      rendered and (b) reimbursement for reasonable expenses incurred on behalf of
      the
      Corporation. No officer, director or shareholder, or any member of their
      immediate families, is, directly or indirectly, interested in any material
      contract with the Corporation (other than such contracts as relate to any such
      person's ownership of shares or other securities of the Corporation). The
      Corporation is not a guarantor or indemnitor of any indebtedness of any other
      person or corporation. 

     

    
      	
              3.1.11

            	
              Changes

            

    

     

    Except
      as
      set forth in Schedule of Exceptions, since the Financial Statement Date, there
      has not been to the Corporation's knowledge:

     

    
      	 	
              (a)

            	
              any
                change in assets, liabilities or operations of the Corporation from
                that
                reflected in the Financial Statements, other than changes in the
                ordinary
                course of business, none of which individually or in the aggregate
                has had
                a material adverse effect on such assets, liabilities or operations
                of the
                Corporation. 

            

    

     

    
      	 	
              (b)

            	
              any
                change, except in the ordinary course of business, in the contingent
                obligations of the Corporation by way of guaranty, endorsement, indemnity,
                warranty or otherwise;

            

    

     

    
      
        
        

      

      
        -10-

        
          

        

      

      
        
        

      

    

    
      	 	
              (c)

            	
              any
                damage, destruction or loss whether or not covered by insurance,
                materially and adversely affecting the properties, business or prospects
                or financial condition of the
                Corporation;

            

    

     

    
      	 	
              (d)

            	
              any
                waiver by the Corporation of a valuable right or of a material debt
                owed
                to it;

            

    

     

    
      	 	
              (e)

            	
              any
                direct or indirect loans by the Corporation to any shareholder, employee,
                officer or director of the
                Corporation;

            

    

     

    
      	 	
              (f)

            	
              any
                material change in any compensation arrangement or agreement with
                any
                employee, officer, director or
                shareholder;

            

    

     

    
      	 	
              (g)

            	
              any
                declaration or payment of any dividend or other distribution of the
                assets
                of the Corporation;

            

    

     

    
      	 	
              (h)

            	
              any
                debt, obligation or liability incurred, assumed or guaranteed by
                the
                Corporation, except those for immaterial amounts and for other liabilities
                incurred in the ordinary course of
                business;

            

    

     

    
      	 	
              (i)

            	
              any
                sale, assignment or transfer of any patent, trademarks, copyrights,
                trade
                secret or other intangible assets;
                or

            

    

     

    
      	 	
              (j)

            	
              any
                change in any material agreement to which the Corporation is a party
                or by
                which it is bound.

            

    

     

    
      	
              3.1.12

            	
              Title
                to Properties and Assets; Liens, Etc. 

            

    

     

    Except
      as
      disclosed in the Schedule of Exceptions, the Corporation has good and marketable
      title to its properties and assets, including the properties and assets
      reflected in the Financial Statements, and good title to its leasehold estates,
      in each case subject to no mortgage, pledge, lien, lease, encumbrance or charge
      (a “Lien”),
      other
      than (a) those resulting from taxes which have not yet become delinquent, (b)
      minor liens and encumbrances which do not materially detract from the value
      of
      the property subject thereto or materially impair the operations of the
      Corporation, and (c) those that have otherwise arisen in the ordinary course
      of
      business. Except as disclosed in the Schedule of Exceptions, the Corporation
      is
      in compliance with all material terms of each agreement to which it is a party
      or is otherwise bound.

     

    
      	
              3.1.13

            	
              Intellectual
                Property

            

    

     

    
      	 	
              (a)

            	
              To
                the best of the knowledge of the Corporation and the actual knowledge
                of
                the Sellers, the Corporation owns or possesses sufficient legal rights
                to
                all patents, trademarks, service marks, trade names, copyrights,
                trade
                secrets, licenses, information and other proprietary rights and processes
                necessary for its business as now conducted, without any known
                infringement of the rights of others. Except
                as disclosed in the Schedule of Exceptions, there are no outstanding
                options, licenses or agreements of any kind with any third parties
                relating to the foregoing proprietary rights, nor is the Corporation
                bound
                by or a party to any options, licenses or agreements of any kind
                with
                respect to the patents, trademarks, service marks, trade names,
                copyrights, trade secrets, licenses, information and other proprietary
                rights and processes of any other person or entity other than such
                licenses or agreements arising from the purchase of “off the shelf” or
                standard products.

            

    

     

    
      
        
        

      

      
        -11-

        
          

        

      

      
        
        

      

    

    
      	 	
              (b)

            	
              Except
                with respect to the Zeiss letters, which have been disclosed to the
                Buyer,
                the Corporation has not received any communications alleging that,
                by
                conducting its business as presently proposed, the Corporation has
                violated or would violate any of the patents, trademarks, service
                marks,
                trade names, copyrights or trade secrets or other proprietary rights
                of
                any other person or entity, nor is the Corporation aware of any basis
                therefor.

            

    

     

    
      	 	
              (c)

            	
              None
                of the key employees of the Corporation (as named in Section 3.1.19
                hereto) is obligated under any contract (including licenses, covenants
                or
                commitments of any nature) or other agreement, or subject to any
                judgment,
                decree or order of any court or administrative agency, that would
                interfere with their duties to the Corporation or that would conflict
                with
                the Corporation’s business as presently proposed to be conducted.
                

            

    

     

    
      	
              3.1.14

            	
              Compliance
                with Other Instruments- Corporation. 

            

    

     

    Except
      as
      disclosed in the Schedule of Exceptions, the Corporation is not in violation
      or
      default of any term of its current Articles, or of any provision of any
      mortgage, indenture, contract, agreement or instrument to which it is a party
      or
      by which it is bound, or of any judgment, decree, order, writ. The execution,
      delivery, performance of, and compliance with this Agreement, and the sale
      of
      the Shares pursuant hereto, will not, with or without the passage of time or
      giving of notice, result in any violation, or be in conflict with or constitute
      a default under any such term, or result in the creation of any mortgage,
      pledge, lien, encumbrance or charge upon any of the properties or assets of
      the
      license, authorization or approval applicable to the Corporation, its business
      or operations or any of its assets or properties.

     

    
      	
              3.1.15

            	
              Compliance
                with Other Instruments-Sellers. 

            

    

     

    Each
      Seller that is a corporation is not in violation or default of any term of
      its
      current Articles. Each Seller is not in violation of any provision of any
      mortgage, indenture, contract, agreement or instrument to which it/he is a
      party
      or by which it is bound, or of any judgment, decree, order, writ. 

     

    
      	
              3.1.16

            	
              Litigation

            

    

     

    Except
      as
      set forth in the Schedule of Exceptions, there is no action, suit, proceeding
      or
      investigation pending or, to the Corporation’s knowledge, currently threatened
      against the Corporation that questions the validity of this Agreement, or the
      right of the Corporation to enter into any of such agreements, or to consummate
      the transactions contemplated hereby or thereby, or which would reasonably
      be
      expected to result, either individually or in the aggregate, in any material
      adverse change in the assets, conditions, affairs or prospects of the
      Corporation, financially or otherwise, or any change in the current equity
      ownership of the Corporation, nor is the Corporation aware that there is any
      basis for any of the foregoing.

     

    
      
        
        

      

      
        -12-

        
          

        

      

      
        
        

      

    

    
      	
              3.1.17

            	
              Tax
                Returns and Payments

            

    

     

    Subject
      to such facts and qualifications as are set forth in the Schedule of Exceptions,
      the Corporation has filed all Tax returns required to be filed by it. All Taxes
      shown to be due and payable on such returns, any assessments imposed, and to
      the
      Corporation’s knowledge all other Taxes due and payable by the Corporation on or
      before the Closing, have been paid or will be paid on or prior to the time
      they
      are due. The Corporation has no knowledge of any liability of any Tax to be
      imposed upon its properties or assets as of the date of this Agreement that
      is
      not adequately provided for.

     

    
      	
              3.1.18

            	
              Employees

            

    

     

    The
      Corporation has no collective bargaining agreements with any of its
      employees.

     

    
      	
              3.1.19

            	
              Obligations
                of Key Employees

            

    

     

    Each
      Key
      Employee of the Corporation is currently devoting substantially all of his
      or
      her business time to the conduct of the business of the Corporation. The
      Corporation is not aware that any Key Employee of the Corporation is planning
      to
      work less than full time at the Corporation in the future. No Key Employee
      is
      currently working or, to the Corporation’s knowledge, plans to work for a
      competitive enterprise, whether or not such key employee is or will be
      compensated by such enterprise. The Corporation’s Key Employees have executed
      with the Corporation employment agreements that include a non-competition and
      confidentiality provisions, copies of which have been provided to the Buyer.
      For
      the purpose of this Section, the term “Key Employee” shall refer to Rishard
      Weitz, Gerald Weiss and Justin Pedro. Gerald Weiss is also involved in a
      property management company that manages amongst other, family controlled real
      estate. Gerald Weiss is not involved in the day to day management of the
      property management company. 

     

    
      	
              3.1.20

            	
              Registration
                Rights and Voting Rights

            

    

     

    The
      Corporation has not agreed to grant any registration rights, including piggyback
      rights, to any person or entity.

     

    
      	
              3.1.21

            	
              Compliance
                with Laws; Permits

            

    

     

    Except
      as
      disclosed in the Schedule of Exceptions, the Corporation and the Sellers are
      not
      aware of any violation by the Corporation of any applicable statute, rule,
      regulation, order or restriction of any domestic or foreign government or any
      instrumentality or agency thereof in respect of the conduct of its business
      or
      the ownership of its properties which violation would materially and adversely
      affect the business, assets, liabilities, financial condition, operations or
      prospects of the Corporation. No governmental orders, permissions, consents,
      approvals or authorizations are required to be obtained and no registrations
      or
      declarations are required to be filed in connection with the execution and
      delivery of this Agreement, except such as has been duly and validly obtained
      or
      filed, or with respect to any filings that must be made, or tax to be paid,
      after the Closing, as will be filed in a timely manner. The Corporation has
      all
      franchises, permits, licenses and any similar authority necessary for the
      conduct of its business as now being conducted by it, the lack of which could
      materially and adversely affect the business, properties or financial condition
      of the Corporation and believes it can obtain, without undue burden or expense,
      any similar authority for the conduct of its business as planned to be
      conducted.

     

    
      
        
        

      

      
        -13-

        
          

        

      

      
        
        

      

    

    
      	
              3.1.22

            	
              Full
                Disclosure

            

    

     

    To
      the
      Seller’s knowledge, neither this Agreement, the exhibits and schedules hereto
      nor any other document delivered by the Corporation and the Sellers to the
      Buyer
      or their attorneys or agents in connection herewith or therewith or with the
      transactions contemplated hereby or thereby, contain any untrue statement of
      a
      material fact nor, to the best of the Seller’s knowledge, omit to state a
      material fact necessary in order to make the statements contained herein or
      therein not misleading.

     

    
      	
              3.1.23

            	
              Insurance

            

    

     

    The
      Corporation’s policies of insurance, as listed on the Schedule of Exceptions,
      have been fully disclosed to the Buyer.

     

    
      	
              3.1.24

            	
              Securities
                Legislation

            

    

     

    The
      Corporation is a private company within the meaning of the Securities Act
      (Ontario) and the sale of the Shares by each Seller to the Buyer will be made
      in
      compliance with the Securities Act (Ontario). 

     

    
      	
              3.1.25

            	
              Section
                6.2 of the Share Purchase
                Agreement

            

    

     

    Except
      as
      disclosed in the Schedule of Exceptions, between
      the date of the Share Purchase Agreement and the date hereof, the Corporation
      has complied with all of the conditions and restrictions set out in Section
      6.2
      of the Share Purchase Agreement.

     

    
      	
              3.1.26

            	
              Acknowledgement
                of Exchange Agreement

            

    

     

    For
      purposes of their decision to enter into this Share Purchase Agreement, the
      Sellers acknowledge and agree that they are aware of and understand the
      provisions in Section 6.3 of the Exchange Agreement relative to the Opko Common
      Shares issuable in exchange for the Exchangeable Shares. Capitalized terms
      in
      this Section 3.1.26
      unless
      otherwise defined herein have the meanings ascribed to them in the Exchange
      Agreement.

     

    
      	
              3.2

            	
              Representations
                and Warranties of the
                Buyer

            

    

     

    The
      Buyer
      represents and warrants to the Seller as set out in the following Subsections
      of
      this Section and acknowledges that the Seller is relying upon such
      representations and warranties in entering into this Agreement. 

     

    
      	
              3.2.1

            	
              Organization
                and Qualification

            

    

     

    Each
      of
      the Buyer and Holdco are duly organized and validly existing under the laws
      of
      Ontario, Canada. Each of the Buyer and Holdco have all requisite corporate
      power
      and authority to own and operate their properties and assets, and to carry
      out
      the provisions of this Agreement and to carry on its business as presently
      conducted. The Buyer has all the requisite corporate power and authority to
      issue the Exchangeable Shares

     

    
      
        
        

      

      
        -14-

        
          

        

      

      
        
        

      

    

    
      	
              3.2.2

            	
              Subsidiaries

            

    

     

    The
      Buyer
      does not own or control any equity, security or other interest of any other
      corporation, limited partnership or other business entity.

     

    
      	
              3.2.3

            	
              Capitalization
                of the Buyer

            

    

     

    The
      authorized capital of the Buyer consists solely of an unlimited number of common
      shares and an unlimited number of Exchangeable Shares, of which 1 common share
      is issued and outstanding. All of the outstanding common shares of the Buyer
      are
      owned by Holdco, have been validly issued and are fully paid and non-assessable.
      The Exchangeable Shares, when issued, will be validly issued as fully paid
      and
      non-assessable. The issuance of the Exchangeable Shares by the Buyer to each
      Seller will be made in compliance with all applicable securities
      legislation.

     

    
      	
              3.2.4

            	
              Capitalization
                of the Holdco

            

    

     

    The
      authorized capital of the Holdco consists solely of an unlimited number of
      common shares, of which 1 common share is issued and outstanding. All of the
      outstanding common shares of Holdco are owned by Opko, have been validly issued
      and are fully paid and non-assessable. 

     

    
      	
              3.3

            	
              Non-waiver/Schedule
                of Exceptions

            

    

     

    
      	
              3.3.1

            	
              Non-Waiver

            

    

     

    No
      investigations made by or on behalf of the Buyer at any time shall waive,
      diminish the scope of or otherwise affect any representation or warranty made
      by
      any Seller or the Corporation in this Agreement or in any Closing Document.
      No
      waiver by the Buyer of any condition, in whole or in part, shall operate as
      a
      waiver of any other condition.

     

    
      	
              3.3.2

            	
              Schedule
                of Exceptions

            

    

     

    Items
      set
      forth by the Sellers in the Schedule of Exceptions will be considered
      disclosures applicable for
      the
      purposes of all representations
      and warranties of the Sellers given
      in
      Section 3.1
      to which
      its relevance is readily apparent. 

     

    
      	
              3.4

            	
              Tax
                Covenants

            

    

     

    At
      the
      option of each Seller, such Seller and the Buyer agree to file a joint election
      pursuant to subsection 85(1) of the Income Tax Act (Canada)(the “Tax
      Act”)
      in the
      prescribed form and within the prescribed time whereby the elected amount
      provided for therein shall be such amount as is determined by such Seller in
      accordance with the limits established under the Tax Act. The Buyer and the
      Seller agree to jointly make and file elections under the corresponding
      provisions of any applicable provincial income tax legislation. Each Seller
      shall be responsible to prepare and file all such elections. The sole obligation
      of the Buyer shall be to provide any information reasonably requested by the
      Sellers to complete the election forms and to execute and return to the Sellers
      any properly completed election form within 10 Business Days of receipt of
      such
      form from the Sellers. The Buyer shall have no liability for any Taxes of the
      Seller arising from the sale of the Shares to the Buyer arising as a result
      of
      the refusal by the Canada Revenue Agency (or any applicable provincial tax
      authority) to accept any such election. 

     

    
      
        
        

      

      
        -15-

        
          

        

      

      
        
        

      

    

    
      	
              3.5

            	
              Survival
                of Representations and Warranties 

            

    

     

    The
      representations and warranties contained in this Agreement and in any agreement,
      certificate, affidavit, statutory declaration or other document delivered or
      given pursuant to this Agreement shall survive the Closing and, notwithstanding
      the Closing or any investigation made by or on behalf of the parties hereto
      with
      respect thereto, shall continue in full force and effect provided, however,
      that
      no claim in respect thereof shall be valid unless it is made within the
      following time periods:

     

    
      	 	
              (a)

            	
              in
                the case of a claim in respect of the representations and warranties
                set
                forth in 3.1.1
                (Organization and qualification of the Corporation), 3.1.2
                (Organization and qualification of the Seller), 3.1.4
                (Capitalization and title), 3.1.5
                (Authorization of the Corporation), 3.1.6
                (Authorization of the Seller), 3.2.1
                (Organization and Qualification of the Buyer and Holdco), 3.2.3
                (Capitalization of the Buyer) and 3.2.4
                (Capitalization of Holdco) there shall be no time limit within which
                such
                a claim may be made; 

            

    

     

    
      	 	
              (b)

            	
              in
                the case of a claim in respect of a representation or warranty relating
                to
                a tax matter, within a period commencing on the date hereof and ending
                on
                the date on which the last applicable limitation period under any
                applicable tax legislation expires with respect to any taxation year
                which
                is relevant in determining any liability under this Agreement with
                respect
                to tax matters; and

            

    

     

    
      	 	
              (c)

            	
              in
                the case of a claim in respect of any other representation or warranty
                within a period of two years from the date
                hereof.

            

    

     

    

     

    
      	
              3.6

            	
              Knowledge
                of the Sellers

            

    

     

    Where
      any
      representation or warranty contained in this Agreement is expressly qualified
      by
      reference to the "knowledge" of the Sellers, it shall be deemed to refer to
      the
      knowledge of each of the Seller and the Corporation, after having made
      reasonable inquiry.

     

    
      
        
        

      

      
        -16-

        
          

        

      

      
        
        

      

    

    ARTICLE
      4

    NON-SOLICITATION
      AND NON-COMPETE

    

     

    
      	
              4.1

            	
              Non
                - Competition

            

    

     

    Each
      of
      Weitz and Gerald covenants and agrees that during the Restricted Period, he
      will
      not, either individually or in partnership or jointly or in conjunction with
      any
      Person as employee, principal, agent, shareholder (other than as a holder of
      not
      more than five percent (5%) of the total stock of a publicly-traded company)
      or
      in any other manner whatsoever carry on, be engaged with, or lend his name
      to
      any Competitive Business in Canada or, the United States. 

     

    
      	
              4.2

            	
              Non
                -Solicitation of Employees or
                Consultant.

            

    

     

    Each
      of
      Weitz and Gerald further covenants and agrees that during the Restricted Period,
      he shall not directly or indirectly, either individually or in partnership
      or
      jointly or in conjunction with any Person, enter into any agreement with or
      solicit the employment or services of employees of or consultants to the
      Corporation, including employees and consultants who were employed with or
      retained by the Corporation on the Closing.

     

    
      	
              4.3

            	
              Non-Solicitation
                of Clients.

            

    

     

    Each
      of
      Weitz and Gerald further covenants and agrees that during the Restricted Period,
      he shall not directly or indirectly, either individually or in partnership
      or
      jointly or in conjunction with any Person, contact or solicit the business
      (of
      the type included within the meaning of Competitive Business) of clients of
      the
      Corporation; any Person who was a client of the Corporation in the two-year
      period immediately prior to the Closing Date. 

     

    
      	
              4.4

            	
              Restrictions
                Reasonable 

            

    

     

    Each
      of
      Weitz and Gerald herby agrees that all of the restrictions in this Agreement
      are
      reasonable and enforceable, and that the Buyer would not have entered into
      this
      Agreement unless he provided the covenants in this Agreement. Each of Weitz
      and
      Gerald further acknowledges and agrees that:

     

    
      	 	
              (a)

            	
              the
                goodwill associated with the business, clients and assets of the
                Corporation as of the Closing is an integral component of the value
                of the
                Corporation to the Buyer;

            

    

     

    
      	 	
              (b)

            	
              the
                covenants set forth herein are necessary to preserve the value of
                the
                Business for the Buyer following the Closing of the transaction;
                and
                

            

    

     

    
      	 	
              (c)

            	
              the
                limitations of time, geography and scope of the Business agreed to
                in this
                Agreement are reasonable because, among other
                things;

            

    

     

    
      	 	
              (a)

            	
              each
                of Weitz and Gerald received significant consideration for his shares
                in
                the Corporation under the Share Purchase Agreement, and each Seller
                acknowledges that it would be unfair for him, after having received
                this
                consideration, to directly or indirectly complete against the Corporation
                during the Restricted Period;

            

    

     

    
      
        
        

      

      
        -17-

        
          

        

      

      
        
        

      

    

    
      	 	
              (b)

            	
              the
                Corporation is engaged in a highly competitive industry;
                and

            

    

     

    
      	 	
              (c)

            	
              each
                of Weitz and Gerald has unique and important relationships with the
                clients of the Corporation and significant business reputation on
                the
                industry.

            

    

     

    
      	
              4.5

            	
               Injunctive
                Relief

            

    

     

    Each
      of
      Weitz and Gerald recognizes that his covenants in this Agreement are critical
      to
      the ongoing success of the Business that the buyer is acquiring from the
      Corporation. As such, each of Weitz and Gerald agrees that in the event of
      an
      actual or threatened breach by him of any of the terms of this Agreement, the
      Buyer will suffer irreparable harm, and shall be entitled to an interim and/or
      permanent injunction against Weitz and/or Gerald, as the case may be,
      restraining such actual or threatened breach. The Buyer shall also be entitled
      to pursue damages and any and all other remedies available to it at law or
      in
      equity.

     

    ARTICLE
      5

    INDEMNIFICATION

     

    
      	
              5.1

            	
              Indemnification
                by the Sellers

            

    

     

    Other
      than with respect to Shane Dunne whose indemnification shall be deemed to be
      several and separate not joint and several, Sections 3.1.2
      (Organization and Qualification of the Sellers), 3.1.4(b)
      (Title),
3.1.6
      (Authorization of the Sellers), and 3.1.15
      (Compliance with other instruments-Sellers) which indemnification shall be
      deemed to be several and separate and not joint and several, and, subject to
      the
      limitations set out in Sections 3.5
      and
7.9,
      each
      Seller shall, jointly and severally, indemnify, defend and save harmless the
      Buyer and each of its Representatives from and against any and all Losses
      suffered or incurred by them, as a result of:

     

    
      	 	
              (a)

            	
              any
                misrepresentation or breach of warranty made or given by any of them
                in
                this Agreement or in any document delivered pursuant to this Agreement
                or
                any Closing Document ;

            

    

     

    
      	 	
              (b)

            	
              save
                and except with respect to covenants of Weitz and Gerald Weiss pursuant
                to
                ARTICLE
                4
                and pursuant to the Employment Agreements and the Confidentiality
                and
                Proprietary Information Agreements and the Non-Competition and
                Non-Solicitation Agreements attached thereto (which covenants and
                Employment Agreements, Confidentiality and Proprietary Information
                Agreements and Non-Competition and Non-Solicitation Agreements shall
                be
                severally indemnified by Weitz and Gerald Weiss alone, and by no
                other
                Seller), any failure by any of them to observe or perform any covenant
                or
                obligation contained in this Agreement, any Closing Document or in
                any
                document delivered pursuant to any of them, to be observed or performed
                by
                it; or

            

    

     

    
      
        
        

      

      
        -18-

        
          

        

      

      
        
        

      

    

    
      	 	
              (c)

            	
              any
                Taxes required to be paid by the Corporation relating to any period
                ending
                on or before the date hereof.

            

    

     

    
      	
              5.2

            	
              Indemnification
                by the Buyer

            

    

     

    Subject
      to the limitations set out in Section 3.5,
      the
      Buyer shall indemnify, defend and save harmless each of the Sellers and each
      of
      the Sellers’ Representatives from and against any and all Losses suffered or
      incurred by them, as a result of:

     

    
      	 	
              (a)

            	
              any
                misrepresentation or breach of any warranty made or given by the
                Buyer in
                this Agreement;

            

    

     

    
      	 	
              (b)

            	
              any
                misrepresentation or breach of warranty made or given by the Buyer
                in any
                Closing Document or in any document delivered pursuant to this Agreement
                or any Closing Document; or

            

    

     

    
      	 	
              (c)

            	
              any
                failure by the Buyer to observe or perform any covenant or obligation
                contained in this Agreement, any Closing Document or in any document
                delivered pursuant to any or them, to be observed or performed by
                it.

            

    

     

    
      	
              5.3

            	
              Defence
                of Claims

            

    

     

    
      	 	
              (a)

            	
              A
                party hereto (the “Indemnified
                Party”)
                who seeks indemnification hereunder from another party (the “Indemnifying
                Party”)
                shall notify the Indemnifying Party in writing as soon as is possible
                after being informed that facts exist which may result in a claim
                and in
                respect of which a right of indemnification given pursuant to this
                Article
                5 may apply. The failure of any Indemnified Party to give timely
                notice
                hereunder shall not affect rights to indemnification hereunder, except
                and
                only to the extent that, the Indemnifying Party demonstrates actual
                material damage caused by such
                failure.

            

    

     

    
      	 	
              (b)

            	
              In
                the case of a claim originating from a Person other than the Indemnified
                Party (a “Third
                Party Claim”),
                the Indemnifying Party shall have the right to elect, by written
                notice
                delivered to the Indemnified Party within thirty (30) days of receipt
                by
                the Indemnifying Party of the notice from the Indemnified Party in
                respect
                of the Third Party Claim, at the sole expense, cost and risk of the
                Indemnifying Party to participate in or assume control of the defence
                of
                the Third Party Claim and
                to pursue such defence in good faith by appropriate actions or proceedings
                promptly taken or instituted and diligently pursued, including, without
                limitation, to employ and engage attorneys of its own choice reasonably
                acceptable to the Indemnified Party to defend, compromise or settle
                such
                claim, provided that
                the Indemnifying Party shall pay all reasonable out-of-pocket expenses
                incurred by the Indemnified Party as a result of such participation
                or
                assumption, provided,
                further,
                that any
                compromise or settlement shall be made only with the written consent
                of
                the Indemnified Party, such consent not to be unreasonably
                withheld.

            

    

     

    
      
        
        

      

      
        -19-

        
          

        

      

      
        
        

      

    

    
      	 	
              (c)

            	
              If
                the Indemnifying Party elects to assume control of the Third Party
                Claim,
                the Indemnifying Party shall keep the Indemnified Party reasonably
                informed of the progress of any defence, compromise or settlement
                and the
                Indemnified Party shall cooperate with the Indemnifying Party and
                its
                counsel and shall have the right to participate in the defence, compromise
                or settlement of such Third Party Claim at its own expense and, in
                so
                doing, the Indemnified Party shall have the right to retain counsel
                to act
                on its behalf, provided
                that
                the fees and disbursements of such counsel shall be paid by the
                Indemnified Party.

            

    

     

    
      	 	
              (d)

            	
              If
                the Indemnifying Party does not elect to assume control of the Third
                Party
                Claim, or if having so elected
                to
                assume control, it thereafter fails to proceed with the defence or
                settlement of such Third Party Claim in good faith and with reasonable
                diligence, then the Indemnified Party shall be entitled to assume
                control
                of the Third Party Claim at the Indemnifying Party’s sole expense, cost
                and risk. An Indemnified Party agreeing to assume control of a claim
                shall
                use commercially reasonable efforts to deal with the claim reasonably
                diligently and in a manner consistent with the manner in which the
                Indemnified Party would have acted if there had been no indemnity.
                In such
                case, the Indemnifying Party shall be kept reasonably informed of
                the
                progress of any defence, compromise or settlement (and shall be entitled
                to participate in at its expense, but not assume control of, such
                action).

            

    

     

    
      	 	
              (e)

            	
              The
                Indemnifying Party or the Indemnified Party who does not have control
                of
                the Third Party Claim shall cooperate with the other of them in the
                defence thereof (at the cost and expense of the Indemnifying Party),
                such
                cooperation to include the provision of records and information within
                its
                control that are relevant to the Third Party Claim and making available
                its employees and servants (and those of its affiliates) as are
                appropriate and reasonably necessary and relevant to the Third Party
                Claim.

            

    

     

     

    ARTICLE
      6

    CLOSING
      DELIVERIES

     

    
      	
              6.1

            	
              Closing
                Deliveries of the Seller

            

    

    

    At
      Closing, in addition to any other documents to be provided or delivered by
      the
      Sellers to the Buyer at such time pursuant to this Agreement, each Seller will
      execute and/or deliver (or cause to be executed and/or delivered) to the Buyer
      the following:

     

    
      	 	
              (a)

            	
              the
                Exchange and Support Agreement;

            

    

     

    
      
        
        

      

      
        -20-

        
          

        

      

      
        
        

      

    

    
      	 	
              (b)

            	
              a
                release from each of the Sellers and the directors and officers of
                the
                Corporation of all claims such Sellers, officers and directors had
                now
                have or shall ever have against the Corporation in a form satisfactory
                to
                the Buyer other than with respect to the subject matter
                hereof;

            

    

     

    
      	 	
              (c)

            	
              the
                    Escrow Agreement;

            

    

     

    
      	 	
              (d)

            	
              a
                resignation of all officers and directors of the
                Corporation;

            

    

     

    
      	 	
              (e)

            	
              Employment
                Agreements between the Corporation and Gerald Weiss and Rishard
                Weitz;

            

    

     

    
      	 	
              (f)

            	
              Option
                Agreements between Opko Health, Inc. and Gerald Weiss and Rishard
                Weitz;

            

    

     

    
      	 	
              (g)

            	
              share
                certificates representing the Purchased Shares duly endorsed in blank
                for
                transfer;

            

    

     

    
      	 	
              (h)

            	
              a
                resolution of the Board of Directors of the Corporation authorising
                the
                transfer of the Purchased Shares;

            

    

     

    
      	 	
              (i)

            	
              an
                opinion of the Counsel to the Seller and the Corporation in form
                and
                substance satisfactory to the Buyer acting reasonably;
                

            

    

     

    
      	 	
              (j)

            	
              evidence
                in form and substance satisfactory to the Buyer, acting reasonably,
                that
                the shares of the Corporation held by Jean-Paul Chaduc have been
                cancelled
                and the shares of the Corporation held by Nidek Co., Ltd. have been
                purchased by <>;
                and

            

    

     

    
      	 	
              (k)

            	
              such
                other documents as may be reasonably required by the
                Buyer.

            

    

     

    
      	
              6.2

            	
              Closing
                Deliveries of the Buyer

            

    

    

    At
      Closing, in addition to any other documents to be provided or delivered by
      the
      Buyer to the Seller at such time pursuant to this Agreement, the Buyer will
      execute and/or deliver (or cause to be executed and/or delivered) to the Buyer
      the following:

     

    
      	 	
              (a)

            	
              the
                Exchange and Support Agreement;

            

    

     

    
      	 	
              (b)

            	
              Employment
                Agreements between the Corporation and Gerald Weiss and Rishard
                Weitz;

            

    

     

    
      	 	
              (c)

            	
              the
                Escrow Agreement;

            

    

     

    
      	 	
              (d)

            	
              Exchangeable
                Share certificates in the amount of the Purchase Price payable to
                each
                Seller in the name of such Seller;

            

    

     

    
      
        
        

      

      
        -21-

        
          

        

      

      
        
        

      

    

    
      	 	
              (e)

            	
              a
                resolution of the Board of Directors of Newco authorising the issuance
                of
                the Exchangeable Shares in payment of the Purchase
                Price;

            

    

     

    
      	 	
              (f)

            	
              Option
                Agreements between Opko Health, Inc. and Gerald Weiss and Rishard
                Weitz;

            

    

     

    
      	 	
              (g)

            	
              an
                opinion of the U.S. Counsel to Opko in form and substance satisfactory
                to
                the Sellers acting reasonably; and 

            

    

     

    
      	 	
              (h)

            	
              such
                other documents as may be reasonably required by the
                Buyer.

            

    

     

    
      	
              6.3

            	
              Payment
                of Shareholder and Related Party
                Loans

            

    

     

    It
      shall
      be a condition precedent of this Agreement that all loans made by the
      Corporation, by any shareholder of the Corporation or by any related party
      as
      set out in the Schedule of Exceptions shall be repaid in full, including
      principal and interest, prior to completion of the transaction contemplated
      hereby.

     

    
      	
              6.4

            	
              Closing
                Payments

            

    

     

    Immediately
      prior to Closing, the shareholder loans disclosed in Section 3.1.10
      shall
      have been repaid.

     

    ARTICLE
      7

    GENERAL

     

    
      	
              7.1

            	
              Expenses

            

    

     

    The
      Parties agree that OTI shall pay all reasonable costs for representation by
      Ogilvy Renault LLP of OTI and the Sellers and for independent legal advice
      for
      Shane Dunne and Jean-Paul Chaduc, if he becomes a party to this Agreement.
      

     

    
      	
              7.2

            	
              Enurement

            

    

     

    This
      Agreement enures to the benefit of and is binding upon the Parties and their
      respective successors (including any successor by reason of merger or
      amalgamation of any Party) and permitted assigns. 

     

    
      	
              7.3

            	
              Notices
                to Parties 

            

    

     

    Any
      notice, certificate, consent, determination or other communication required
      or
      permitted to be given or made under this Agreement shall be in writing and
      shall
      be effectively given and made if (i) delivered personally, (ii) sent by prepaid
      courier service or mail, or (iii) sent prepaid by fax or other similar means
      of
      electronic communication, in each case to the applicable address set out
      below:

     

    
      
        
        

      

      
        -22-

        
          

        

      

      
        
        

      

    

    
      	 	
              (a)

            	
              if
                to the Corporation:

            

    

    

    Ophthalmic
      Technologies Inc.

    37
      Kodiak
      Crescent

    Unit
      16

    Toronto,
      ON M3J 3E5

    Attention:
      Gerald Weiss

    Fax:
      

     

    with
      a
      copy to:

     

    

    Ogilvy
      Renault LLP

    Suite
      3800, Royal Bank Plaza, South Tower

    200
      Bay
      Street, P.O. Box 84

    Toronto,
      ON M5J 2Z4

    Attention:
      Peter Newell

    Fax:
      416.214.3930

     

    
      	 	
              (b)

            	
              if
                to Newco:

            

    

    

    c/o
      Opko

    4400
      Biscayne Boulevard

    Miami,
      Florida 31337

    Attention: Steven
      D.
      Rubin

    Fax:  

     

    with
      a
      copy to:

     

    Fraser
      Milner Casgrain 

    First
      Canadian Place

    100
      King
      Street West

    P.O.
      Box
      100

    Toronto,
      Ontario M5X 1B2

     

    Attention: Laurence
      Geringer 

    Fax:  416.863.4592

     

    
      	 	
              (c)

            	
              and
                if to the Sellers:

            

    

     

    
      	 	
              (d)

            	 

    

    1161983
      Ontario Limited

    235
      Lesmill Road,

    Don
      Mills, ON M3V 2V1

     

    Attention: 

    Fax:  

    

    
      
        
        

      

      
        -23-

        
          

        

      

      
        
        

      

    

    Grall
      Corporation Limited

    

    Attention: 

    Fax:  

    

    Rishard
      Weitz

    37
      Kodiak
      Crescent, Unit 16

    Toronto,
      ON M3J 3E5

    

    Fax:  (416)
      631-6932

    

    Carolyn
      Weiss

    

    Fax:  

    

    Shane
      Dunne

    95
      Michael Grass Crescent,

    Kingston,
      ON K7M 2W2

    

    Fax:  

    

    Gerald
      Weiss

    37
      Kodiak
      Crescent, Unit 16

    Toronto,
      ON M3J 3E5

    

    Fax:  (416)
      631-6932

    

    Triple
      Net Propertied Limited

    235
      Lesmill Road,

    Don
      Mills, ON M3V 2V1

    

    Fax:  

    

     

    
      	 	
              (e)

            	
              Any
                such communication so given or made shall be deemed to have been
                given or
                made and to have been received on the day of delivery if delivered,
                or on
                the day of faxing or sending by other means of recorded electronic
                communication, provided that such day in either event is a Business
                Day
                and the communication is so delivered, faxed or sent before 4:30
                p.m. on
                such day. Otherwise, such communication shall be deemed to have been
                given
                and made and to have been received on the next following Business
                Day. Any
                such communication sent by mail shall be deemed to have been given
                and
                made and to have been received on the fifth Business Day following
                the
                mailing thereof; provided however that no such communication shall
                be
                mailed during any actual or apprehended disruption of postal services.
                Any
                such communication given or made in any other manner shall be deemed
                to
                have been given or made and to have been received only upon actual
                receipt.

            

    

     

    
      
        
        

      

      
        -24-

        
          

        

      

      
        
        

      

    

    
      	 	
              (f)

            	
              Any
                Party may from time to time change its address under this Section
                by
                notice to the other Party given in the manner provided by this
                Section.

            

    

     

    
      	
              7.4

            	
              Amendment 

            

    

     

    No
      consent or approval by any Party will be binding unless delivered in writing
      to
      the other Parties hereto. 

     

    
      	
              7.5

            	
              Assignment

            

    

     

    No
      party
      may assign any rights or obligations under this Agreement.

     

    
      	
              7.6

            	
              Further
                Assurances

            

    

     

    The
      Parties will, with reasonable diligence, do all such things and provide all
      such
      reasonable assurances as may be required to consummate the transactions
      contemplated by this Agreement, and each party will provide such further
      documents or instruments required by any other Party as may be reasonably
      necessary or desirable to effect the purpose of this Agreement and carry out
      its
      provisions.

     

    
      	
              7.7

            	
              Public
                Announcements

            

    

     

    Except
      to
      the extent required by Applicable Law, each Party agrees that no disclosure
      or
      public announcement regarding this Agreement or the transactions contemplated
      hereby shall be made by either Party without the prior written consent of the
      other Party.

     

    
      	
              7.8

            	
              Remedies
                Cumulative

            

    

     

    The
      rights and remedies of the Parties under this Agreement are cumulative and
      in
      addition to and not in substitution for any rights or remedies provided by
      law.
      Any single or partial exercise by any Party hereto of any right or remedy for
      default or breach of any term, covenant or condition of this Agreement does
      not
      waive, alter, affect or prejudice any other right or remedy to which such Party
      may be lawfully entitled for the same default or breach.

     

    
      	
              7.9

            	
              Limitation
                of Liability

            

    

     

    Other
      than with respect to Shane Dunne whose liability is set out below, Sections
      3.1.2
      (Organization and Qualification of the Sellers), 3.1.4(b)
      (Title),
3.1.6
      (Authorization of the Sellers), and 3.1.15
      (Compliance with other instruments-Sellers), fraud and wilful misconduct, for
      which there shall be no limitation on liability, the aggregate liability of
      the
      Sellers shall not exceed the value of the Escrow Shares and recourse with
      respect thereto shall be limited to the Escrow Shares. 

     

    
      
        
        

      

      
        -25-

        
          

        

      

      
        
        

      

    

    Other
      than with respect Sections 3.1.2
      (Organization and Qualification of the Sellers), 3.1.4(b)
      (Title),
3.1.6
      (Authorization of the Sellers), and 3.1.15
      (Compliance with other instruments-Sellers), fraud and wilful misconduct, for
      which there shall be no limitation on liability, the aggregate liability of
      the
      Shane Dunne shall not exceed the value of the Dunne Escrow Shares and recourse
      with respect thereto shall be limited to the Dunne Escrow Shares. 

     

    
      	
              7.10

            	
              Execution
                and Delivery

            

    

     

    This
      Agreement may be executed by the Parties in counterparts and may be executed
      and
      delivered by fax, and all such counterparts and faxes together constitute one
      agreement.

     

    TO
      WITNESS
      their
      agreement, the parties have duly executed this Agreement as of the date first
      set forth above.

     

     

    [THE
      REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

     

    
      
        
        

      

      
        -26-

        
          

        

      

      
        
        

      

    

     

    

     

    
      	 	
              Ophthalmic
                Technologies Inc.

            	 
	 	 	 
	 	 	 
	 	
              By:
                

            	 	
              c/s

            
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	
              OTI
                Holdings Limited

            	 
	 	 	 
	 	 	 
	 	
              By:
                

            	 	
              c/s

            
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	
              1161983
                Ontario Limited

            	 
	 	 	 
	 	 	 
	 	
              By:
                

            	 	
              c/s

            
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	
              Grall
                Corporation Limited

            	
              c/s

            
	 	 	 
	 	 	 
	 	
              By:
                

            	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	
              Triple
                Net Properties Limited

            	
              c/s

            
	 	 	 
	 	 	 
	 	
              By:
                

            	 	 
	 	 	 	 
	 	 	 	 

    

     

    
      
        
        

      

      
        -27-

        
          

        

      

      
        
        

      

    

    

    
      	 	 	 
	
              Witness

            	 	
              Rishard
                Weitz

            
	 	 	 
	 	 	 
	
              Witness

            	 	
              Carolyn
                Weiss

            
	 	 	 
	 	 	 
	
              Witness

            	 	
              Shane
                dunne

            
	 	 	 
	 	 	 
	
              Witness

            	 	
              Gerald
                Weiss, as
                trustee for and on behalf of Marie-Helene Weiss and Gerald
                Weiss

            
	 	 	 
	 	 	 
	
              Witness

            	 	
              Gerald
                Weiss

            

    

     

    

    

    
      
        
        

      

      
        -28-

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