Document:

INDENTURE

 Exhibit 4.1 
 EXECUTION VERSION 
  

 
 SEQUENOM,
INC. 
 AS ISSUER 

5.00% CONVERTIBLE SENIOR NOTES DUE 2017 
  

 
 INDENTURE

 DATED AS OF SEPTEMBER 17, 2012 

 
  

WELLS FARGO BANK, NATIONAL ASSOCIATION 

AS TRUSTEE 
  

 
  

 

 TABLE OF CONTENTS 

 

							
	 	  	 	  	Page	 
	 ARTICLE 1 DEFINITIONS AND INCORPORATION BY REFERENCE
	  	 	5	 
			
	             Section 1.01
	  	 Definitions.
	  	 	5	 
	             Section 1.02
	  	 Other Definitions.
	  	 	18	 
	             Section 1.03
	  	 [Reserved].
	  	 	19	 
	             Section 1.04
	  	 Rules of Construction.
	  	 	19	 
	             Section 1.05
	  	 Acts of Holders.
	  	 	20	 
		
	 ARTICLE 2 THE NOTES
	  	 	21	 
			
	             Section 2.01
	  	 Designation, Amount and Issuance of Notes.
	  	 	21	 
	             Section 2.02
	  	 Form of Notes.
	  	 	21	 
	             Section 2.03
	  	 Denomination of Notes.
	  	 	22	 
	             Section 2.04
	  	 Payments.
	  	 	22	 
	             Section 2.05
	  	 Execution and Authentication.
	  	 	25	 
	             Section 2.06
	  	 Registrar, Paying Agent and Conversion Agent.
	  	 	25	 
	             Section 2.07
	  	 Money and Securities Held in Trust.
	  	 	27	 
	             Section 2.08
	  	 Holder Lists.
	  	 	27	 
	             Section 2.09
	  	 Transfer and Exchange.
	  	 	28	 
	             Section 2.10
	  	 Transfer Restrictions.
	  	 	32	 
	             Section 2.11
	  	 Replacement Notes.
	  	 	33	 
	             Section 2.12
	  	 Temporary Notes.
	  	 	33	 
	             Section 2.13
	  	 Cancellation.
	  	 	34	 
	             Section 2.14
	  	 Outstanding Notes.
	  	 	34	 
	             Section 2.15
	  	 Persons Deemed Owners.
	  	 	34	 
	             Section 2.16
	  	 Repurchases.
	  	 	34	 
	             Section 2.17
	  	 CUSIP and ISIN Numbers.
	  	 	35	 
		
	 ARTICLE 3 REPURCHASE AT THE OPTION OF THE HOLDER
	  	 	35	 
			
	             Section 3.01
	  	 Fundamental Change Permits Holders To Require The Company To Repurchase the Notes.
	  	 	35	 
	             Section 3.02
	  	 Fundamental Change Notice.
	  	 	36	 
	             Section 3.03
	  	 Fundamental Change Repurchase Notice.
	  	 	37	 
	             Section 3.04
	  	 Withdrawal of Fundamental Change Repurchase Notice.
	  	 	38	 
	             Section 3.05
	  	 Effect of Fundamental Change Repurchase Notice.
	  	 	39	 
	             Section 3.06
	  	 Notes Repurchased in Part.
	  	 	40	 
	             Section 3.07
	  	 Covenant to Comply with Securities Laws upon Repurchase of Notes.
	  	 	40	 
	             Section 3.08
	  	 Deposit of Fundamental Change Repurchase Price.
	  	 	40	 
	             Section 3.09
	  	 Covenant Not to Repurchase Notes upon Certain Events of Default.
	  	 	40	 
		
	 ARTICLE 4 COVENANTS
	  	 	41	 

  
 i 

							
	            Section 4.01	  	Payment of Notes.	  	 	41	 
	            Section 4.02	  	144A Information.	  	 	41	 
	            Section 4.03	  	Reports.	  	 	41	 
	            Section 4.04	  	Additional Interest.	  	 	42	 
	            Section 4.05	  	Compliance Certificate.	  	 	43	 
	            Section 4.06	  	Restriction on Purchases by the Company and by Affiliates of the Company.	  	 	43	 
	            Section 4.07	  	[Reserved].	  	 	43	 
	            Section 4.08	  	Corporate Existence.	  	 	43	 
	            Section 4.09	  	Par Value Limitation.	  	 	44	 
	            Section 4.10	  	Stay, Extension and Usury Laws.	  	 	44	 
	            Section 4.11	  	Further Instruments and Acts.	  	 	44	 
	            Section 4.12	  	Limitation on Incurrence of Additional Indebtedness.	  	 	44	 
		
	ARTICLE 5 CONSOLIDATION, MERGER AND SALE OF ASSETS	  	 	45	 
			
	            Section 5.01	  	Company May Consolidate, Merge or Sell Its Assets Only on Certain Terms.	  	 	45	 
	            Section 5.02	  	Successor Substituted.	  	 	45	 
	            Section 5.03	  	Opinion of Counsel to Be Given to Trustee.	  	 	45	 
		
	ARTICLE 6 DEFAULTS AND REMEDIES	  	 	46	 
			
	            Section 6.01	  	Events of Default.	  	 	46	 
	            Section 6.02	  	Acceleration.	  	 	48	 
	            Section 6.03	  	Other Remedies.	  	 	48	 
	            Section 6.04	  	Sole Remedy for Failure to Report.	  	 	48	 
	            Section 6.05	  	Waiver of Past Defaults.	  	 	49	 
	            Section 6.06	  	Control by Majority.	  	 	50	 
	            Section 6.07	  	Limitation on Suits.	  	 	50	 
	            Section 6.08	  	Rights of Holders To Receive Payment.	  	 	51	 
	            Section 6.09	  	Collection Suit by Trustee.	  	 	51	 
	            Section 6.10	  	Trustee May File Proofs of Claim.	  	 	51	 
	            Section 6.11	  	Priorities.	  	 	51	 
	            Section 6.12	  	Undertaking for Costs.	  	 	52	 
		
	ARTICLE 7 TRUSTEE	  	 	52	 
			
	            Section 7.01	  	Duties of Trustee.	  	 	52	 
	            Section 7.02	  	Rights of Trustee.	  	 	53	 
	            Section 7.03	  	Individual Rights of Trustee.	  	 	55	 
	            Section 7.04	  	Trustee’s Disclaimer.	  	 	55	 
	            Section 7.05	  	Notice of Defaults.	  	 	55	 
	            Section 7.06	  	Compensation and Indemnity.	  	 	55	 
	            Section 7.07	  	Replacement of Trustee.	  	 	56	 
	            Section 7.08	  	Successor Trustee by Merger.	  	 	57	 
	            Section 7.09	  	Eligibility; Disqualification.	  	 	57	 

  
 ii 

							
	            Section 7.10	  	Trustee’s Application for Instructions from the Company	  	 	57	 
		
	ARTICLE 8 SATISFACTION AND DISCHARGE	  	 	57	 
			
	            Section 8.01	  	Discharge of Liability on Notes	  	 	57	 
	            Section 8.02	  	Repayment to the Company	  	 	58	 
		
	ARTICLE 9	  	 	58	 
		
	AMENDMENTS, SUPPLEMENTS AND WAIVERS	  	 	58	 
			
	            Section 9.01	  	Without Consent of Holders	  	 	58	 
	            Section 9.02	  	With Consent of Holders	  	 	59	 
	            Section 9.03	  	Execution of Supplemental Indentures	  	 	60	 
	            Section 9.04	  	Notices of Supplemental Indentures	  	 	60	 
	            Section 9.05	  	Effect of Supplemental Indentures	  	 	61	 
	            Section 9.06	  	Revocation and Effect of Consents, Waivers and Actions.	  	 	61	 
	            Section 9.07	  	Notation on, or Exchange of, Notes	  	 	61	 
		
	ARTICLE 10 CONVERSIONS	  	 	62	 
			
	            Section 10.01	  	Right To Convert.	  	 	62	 
	            Section 10.02	  	Conversion Procedures.	  	 	62	 
	            Section 10.03	  	Conversion Obligation.	  	 	64	 
	            Section 10.04	  	Common Stock Issued Upon Conversion.	  	 	65	 
	            Section 10.05	  	Adjustment of Conversion Rate	  	 	65	 
	            Section 10.06	  	Voluntary Adjustments.	  	 	73	 
	            Section 10.07	  	Adjustments Upon Certain Fundamental Changes.	  	 	74	 
	            Section 10.08	  	Effect of Recapitalization, Reclassification, Consolidation, Merger or Sale.	  	 	76	 
	            Section 10.10	  	Notice to Holders Prior to Certain Actions.	  	 	77	 
	            Section 10.11	  	No Responsibility of Trustee	  	 	78	 
		
	ARTICLE 11 REDEMPTION AT THE OPTION OF THE COMPANY	  	 	79	 
			
	            Section 11.01	  	No Sinking Fund. No sinking fund is provided for the Notes.	  	 	79	 
	            Section 11.02	  	Right To Redeem the Notes.	  	 	79	 
	            Section 11.03	  	Redemption Notice.	  	 	79	 
	            Section 11.04	  	Effect of Redemption Notice	  	 	80	 
	            Section 11.05	  	Deposit of Redemption Price	  	 	80	 
	            Section 11.06	  	Effect of Deposit.	  	 	80	 
	            Section 11.07	  	Covenant Not to Redeem Notes Upon Certain Events of Default.	  	 	81	 
	            Section 11.08	  	Repayment to the Company.	  	 	81	 
		
	ARTICLE 12 MISCELLANEOUS	  	 	82	 
			
	            Section 12.01	  	[Reserved].	  	 	82	 

  
 iii

							
	             Section 12.02
	  	Notices	  	 	82	 
	             Section 12.03
	  	Certificate and Opinion as to Conditions Precedent	  	 	83	 
	             Section 12.04
	  	Statements Required in Certificate or Opinion	  	 	83	 
	             Section 12.05
	  	Separability Clause	  	 	83	 
	             Section 12.06
	  	Rules by Trustee	  	 	83	 
	             Section 12.07
	  	Governing Law and Waiver of Jury Trial	  	 	83	 
	             Section 12.08
	  	No Recourse Against Others	  	 	84	 
	             Section 12.09
	  	Calculations	  	 	84	 
	             Section 12.10
	  	Successors	  	 	84	 
	             Section 12.11
	  	Multiple Originals	  	 	84	 
	             Section 12.12
	  	Table of Contents; Headings	  	 	84	 
	             Section 12.13
	  	Force Majeure	  	 	84	 
	             Section 12.14
	  	Submission to Jurisdiction	  	 	85	 
	             Section 12.15
	  	Legal Holidays	  	 	85	 
	             Section 12.16
	  	No Security Interest Created	  	 	85	 
	             Section 12.17
	  	Benefits of Indenture	  	 	85	 
	             Section 12.18
	  	U.S.A. Patriot Act	  	 	85	 
		
	 Form of Note
	  	 	A-1	  
	 Form of Transfer Certificate
	  	 	B-1	  
	 Form of Free Transferability Certificate
	  	 	C-1	  
	 Form of Restricted Stock Legend
	  	 	D-1	  

  
 iv 

 INDENTURE, dated as of September 17, 2012, between Sequenom, Inc., a Delaware
corporation (“Company”), and Wells Fargo Bank, National Association, a national banking association, as trustee (“Trustee”). 
 Each party agrees as follows for the benefit of the other party and for the equal and ratable benefit of the Holders (as defined below) of the Company’s 5.00% Convertible Senior Notes due 2017:

 ARTICLE 1 
 DEFINITIONS AND INCORPORATION BY REFERENCE 
 Section 1.01
Definitions. 
 “Affiliate” of any specified Person means any other Person, directly or indirectly,
controlling or controlled by or under direct or indirect common control with such specified Person. For the purposes of this definition, “control,” when used with respect to any specified Person, means the power to direct or cause
the direction of the management and policies of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have
meanings correlative to the foregoing. 
 “Applicable Procedures” means, with respect to any transfer or
transaction involving a Global Note or any beneficial interest therein, the rules and procedures of the Depositary for such Note, in each case to the extent applicable to such transfer or transaction and as in effect from time to time. 

“Attributable Indebtedness” means on any date, (a) in respect of any Capital Lease of any Person, the capitalized
amount of the obligations under such Capital Lease determined in accordance with GAAP, and (b) in respect of any Synthetic Lease Obligation, the capitalized amount of the remaining lease payments under the relevant lease that would appear on a
balance sheet of such Person prepared as of such date in accordance with GAAP if such lease were accounted for as a Capital Lease. 
 “Bankruptcy Law” means Title 11, United States Code, or any similar U.S. federal, state or non-U.S. law for the relief of debtors. 

“Bloomberg” means Bloomberg LLP and any successor Person serving a similar function. 

“Board of Directors” means the board of directors of the Company or a committee of such board duly authorized to act for
it. 
 “Board Resolution” means a copy of one or more resolutions certified by the Secretary or an Assistant
Secretary of the Company to have been duly adopted by the Board of Directors and to be in full force and effect on the date of such certification, and delivered to the Trustee. 

  
 5 

 “Business Day” means any day other than a Saturday, a Sunday or a day on
which the Federal Reserve Bank of New York or the place of payment is authorized or required by law or executive order to close or be closed. 
 “Capital Lease” means any lease that is required to be capitalized for financial reporting purposes in accordance with GAAP (with the amount of any Indebtedness in respect of a Capital
Lease being the capitalized amount of the obligations under such Capital Lease determined in accordance with GAAP). 

“Capital Stock” means, for any Person, any and all shares, interests, rights to purchase, warrants, options,
participations or other equivalents of, or interests in (however designated), the equity of such Person, but excluding any debt securities that are convertible into, or exchangeable for, such equity. 

“Close of Business” means 5:00 p.m., New York City time. 

“Common Stock” means the shares of the common stock of the Company, par value $0.001 per share, or any other shares of
Capital Stock of the Company into which such shares of common stock will be reclassified or changed after the Issue Date. 

“Company” means the party named as such in the first paragraph of this Indenture until a successor or assignee replaces
it pursuant to the applicable provisions hereof and, thereafter, means the successor or assignee. 
 “Company
Order” means a written request or order signed in the name of the Company by any Officer. 
 “Consolidated
EBITDA” means, for any period, an amount equal to Consolidated Net Income for such period plus: 
 (a) the following to
the extent deducted in calculating such Consolidated Net Income: 
 (i) Consolidated Interest Charges for such period;

 (ii) the provision for Federal, state, local and foreign income taxes payable by the Company and the Subsidiaries for such
period; 
 (iii) depreciation and amortization expense; 

(iv) non-cash expenses and amortization related to the granting of stock options and restricted stock grants to employees and directors
of the Company and the Subsidiaries; 
 (v) other expenses or charges of the Company and the Subsidiaries reducing such
Consolidated Net Income which do not represent a cash item in such period or any future period; 

  
 6 

 (vi) any non-recurring charges, costs, fees and expenses directly incurred or paid directly
as a result of discontinued operations (other than such charges, costs, fees and expenses to the extent constituting losses arising from discontinued operations); 
 (ix) restructuring expenses and charges and any costs, charges, fees and expenses incurred in connection with any acquisition, investment or any non-ordinary course disposition of assets; and 

(x) impairment charges, including the write down of investments, 

and minus 
 (b)
the following to the extent included in calculating such Consolidated Net Income: 
 (i) Federal, state, local and foreign
income tax credits of the Company and the Subsidiaries for such period; and 
 (ii) all non-cash items increasing Consolidated
Net Income for such period. 
 In addition, Consolidated EBITDA shall be adjusted on a pro forma basis, as of the first day of
any applicable period, for any expenses related to acquisitions and dispositions of assets by the Company or the Subsidiaries during or subsequent to the applicable period that the Company determines in good faith are outside the ordinary course of
business, calculated consistent with GAAP and Regulation S-X promulgated under the Exchange Act; provided that notwithstanding Regulation S-X, pro forma adjustments may include net operating expense reductions for such period resulting from
the transaction or transactions which is being given pro forma effect that are reasonably expected to be realized in the Company’s good faith judgment within the twelve months following the transaction. 

“Consolidated Fixed Charge Coverage Ratio” means, as of any date of determination, the ratio of (a) Consolidated
EBITDA to (b) Consolidated Fixed Charges, in each case, for the four consecutive fiscal quarters most recently ended. 

“Consolidated Fixed Charges” means, for any period, the sum of the following determined on a consolidated basis, for the
Company and the Subsidiaries on a consolidated basis in accordance with GAAP: 
 (a) Consolidated Interest Charges for such
period (excluding amortization or write-off of deferred financing costs and original issue discount); 
 (b) cash taxes paid
during such period; 
 (c) the amount of scheduled and mandatory principal payments with respect to Indebtedness for such
period; and 

  
 7 

 (d) cash dividends and distributions made with respect to the Company’s Equity
Interests during such period. 
 “Consolidated Funded Indebtedness” means, as of any date of determination, for
the Company and the Subsidiaries on a consolidated basis, the sum of all of the Company and the Subsidiaries’ Indebtedness determined on a consolidated basis; provided, however, that Consolidated Funded Indebtedness shall not include any
Subordinated Indebtedness, or any Indebtedness of the type referenced in clauses (b), (c) and (g) of the definition of Indebtedness or clauses (h), (i), (j), (m) and (n) of the definition of Permitted Debt. 

“Consolidated Interest Charges” means, for any period, for the Company and the Subsidiaries on a consolidated basis, the
sum of (a) all interest, premium payments, debt discount, fees, charges and related expenses of the Company and the Subsidiaries in connection with borrowed money (including capitalized interest) or in connection with the deferred purchase
price of assets, in each case to the extent treated as interest in accordance with GAAP, and (b) the portion of rent expense of the Company and the Subsidiaries with respect to such period under Capital Leases that is treated as interest in
accordance with GAAP. 
 “Consolidated Leverage Ratio” means, as of any date of determination, the ratio of:
(a) Consolidated Funded Indebtedness as of such date to (b) Consolidated EBITDA for the period of the four consecutive fiscal quarters most recently ended. 
 “Consolidated Net Income” means, for any period, the consolidated net income (or loss) of the Company and the Subsidiaries for such period as determined in accordance with GAAP, adjusted
to the extent included in calculating such net income, by excluding, without duplication: 
 (a) all extraordinary gains or
losses; 
 (b) any gain or loss realized as a result of the cumulative effect of a change in accounting principles; 

(c) any unrealized gains or losses in respect of hedging obligations (including Swap Contracts); and 

(d) any gains or losses resulting from non-ordinary course dispositions of assets or discontinued operations. 

“Conversion Price” means (i) $1,000 divided by (ii) the Conversion Rate. 

“Conversion Rate” means, initially, 216.0644 shares of Common Stock per $1,000 principal amount of Notes, subject to
adjustment as provided herein. 
 “Corporate Trust Office” means the corporate trust office
of the Trustee at which any time its corporate trust business shall be administered, which office, as of the Issue Date, is located at Wells Fargo Bank, National Association, 707 Wilshire Blvd, 17th Floor, Los Angeles, CA 90017, MAC E2818-176, Attention: Sequenom,
Inc. Account Manager, or such other address as the Trustee may designate from time to time by notice to the Holders and the Company, or the principal corporate trust office of any successor Trustee (or such other address

  
 8 

 
as such successor trustee may designate from time to time by notice to the Holders and the Company). 
 “Credit Agreement” means that certain Loan and Security Agreement, dated as of May 31, 2011, by and among the Company, Sequenom Center for Molecular Medicine, LLC and Silicon Valley
Bank, including any related notes, Guarantees, collateral documents, instruments and agreements executed in connection therewith, and, in each case, as amended, restated, modified, renewed, refunded, replaced in any manner (whether upon or after
termination or otherwise) or refinanced (including by means of sales of debt securities to institutional investors) in whole or in part from time to time. 
 “Credit Facilities” means one or more debt facilities (including, without limitation, the Credit Agreement), indentures or commercial paper facilities, in each case, with banks or other
institutional lenders, accredited investors or institutional investors providing for revolving credit loans, term loans, term debt (including Capital Leases), debt securities, receivables financing (including through the sale of receivables to such
lenders or to special purpose entities formed to borrow from such lenders against such receivables) or letters of credit, in each case, as amended, restated, modified, renewed, extended, increased, refunded, replaced in any manner (whether upon or
after termination or otherwise) or refinanced (including by means of sales of debt securities to institutional investors) in whole or in part from time to time. 
 “Custodian” means any receiver, trustee, assignee, liquidator, custodian or similar official under any Bankruptcy Law. 

“Default” means any event which is, or after notice or passage of time or both would become, an Event of Default
pursuant to Section 6.01. 
 “Defaulted Amount” means any amount on any Note (including, without
limitation, the Redemption Price, the Fundamental Change Repurchase Price, principal and interest) that is payable but is not punctually paid or duly provided for. 
 “Definitive Notes” means Notes that are in registered definitive form. 
 “Depositary” means DTC; provided that the Company may at any time, upon delivering notice to the Holders, the Company, the Trustee, the Registrar, the Paying Agent and the
Conversion Agent, appoint a successor to DTC. 
 “DTC” means The Depository Trust Company. 

“Equity Interests” means Capital Stock and all warrants, options or other rights to acquire Capital Stock (but excluding
any debt security that is convertible into, or exchangeable for, Capital Stock). 
 “Exchange Act” means the
Securities Exchange Act of 1934, as amended. 
 “Free Trade Date” means the date that is one year after the
Issue Date. 

  
 9 

 “Free Transferability Certificate” means a certificate substantially in the
form of Exhibit C. 
 “Freely Tradable” means, with respect to the Notes or any shares of the Common
Stock issuable upon conversion of the Notes, that such Notes or shares of Common Stock, as the case may be, are eligible to be offered, sold or otherwise transferred pursuant to Rule 144 or otherwise pursuant to U.S. securities laws by a Person that
is not an affiliate (as defined in Rule 144) of the Company and that has not been an affiliate (as defined in Rule 144) of the Company during the three immediately preceding months without any volume or manner of sale restrictions. 

“Fundamental Change” means an event that will be deemed to occur if any of the following occurs: 

(i) a “person” or “group” within the meaning of Section 13(d) of the Exchange Act other than the Company, the
Subsidiaries, and the Company and the Subsidiaries’ employee benefit plans, files a Schedule TO or any schedule, form or report under the Exchange Act disclosing, or the Company otherwise become aware that, such person or group has become the
direct or indirect “beneficial owner” of shares of the Company’s common equity representing more than 50% of the voting power of the Company’s common equity; 

(ii) the consummation of: 
 (A) any sale, lease or other transfer in one transaction or a series of related transactions of all or substantially all of the consolidated assets of the Company and the Subsidiaries, taken as a whole,
to any person or persons (other than one of the Subsidiaries); or 
 (B) any transaction or series of related transactions in
connection with which (whether by means of exchange, liquidation, consolidation, merger, combination, reclassification, recapitalization, acquisition or otherwise) all of the Common Stock is exchanged for, converted into, acquired for, or
constitutes solely the right to receive, other securities, other property, assets or cash, but excluding any merger, consolidation, share exchange or acquisition of the Company with or by another person pursuant to which the persons that
beneficially owned, directly or indirectly, the shares of the Company’s Voting Stock immediately prior to such transaction beneficially own, directly or indirectly, immediately after such transaction, shares of the surviving, continuing or
acquiring corporation’s Voting Stock representing more than 50% of the total outstanding voting power of all outstanding classes of Voting Stock of the surviving, continuing or acquiring corporation in substantially the same proportions
(relative to each other) as immediately prior to such transaction; 
 (iii) the Company’s stockholders approve any plan or
proposal for the liquidation or dissolution of the Company; or 
 (iv) the Common Stock (or other common stock or depositary
shares or receipts in respect thereof into which the Notes are then convertible) ceases to be listed or quoted on any of The New York Stock Exchange, The NASDAQ Global Market or The NASDAQ Global Select Market (or any of their respective
successors). 

  
 10 

 An event, transaction or series of related transactions described in clause (ii) above
will not constitute a Fundamental Change, however, if at least 90% of the consideration received or to be received by the holders of the Common Stock, excluding cash payments for fractional shares or dissenters rights in connection with the
transaction or transactions, consists of shares of common stock traded on any of The New York Stock Exchange, The NASDAQ Global Market or The NASDAQ Global Select Market (or any of their respective successors) or which will be so traded or quoted
when issued or exchanged in connection with such event, transaction or series of related transactions and as a result of such event, transaction or series of related transactions, the Notes become convertible or exchangeable into, or based on, such
consideration (excluding cash payments for fractional shares or dissenters rights) as described in Section 10.08 hereof. For the purposes of this definition of “Fundamental Change,” any event, transaction or series of related
transactions that constitutes a Fundamental Change under both clause (i) and clause (ii) above will be deemed to constitute a Fundamental Change solely under clause (ii) of this definition of “Fundamental Change.”

 For the purposes of this definition of “Fundamental Change,” whether a person is a “beneficial owner” will be
determined in accordance with Rule 13d-3 under the Exchange Act. 
 “GAAP” means generally accepted accounting
principles in the U.S. as in effect on the date of the Indenture. 
 “Global Note” means a permanent global
note that is in the form of the Note attached hereto as Exhibit A and that is registered in the name of the Depositary or the nominee of the Depositary and deposited with the Depositary, the nominee of the Depositary or a custodian appointed
by the Depositary or the nominee of the Depositary. 
 “Global Notes Legend” means the legend set forth as such
in Exhibit A hereto. 
 “Guarantee” means, as to any Person, a guarantee of such Person, other than by
endorsement of negotiable instruments for collection in the ordinary course of business, direct or indirect, in any manner including, without limitation, by way of a pledge of assets or through letters of credit or reimbursement agreements in
respect thereof, of all or any part of any Indebtedness of another Person (whether arising by virtue of partnership arrangements, or by agreements to keep-well, to purchase assets, goods, securities or services, to take or pay or to maintain
financial statement conditions or otherwise). 
 “Holder” or “Holders” means a Person or
Persons in whose name a Note is registered in the Register. 
 “Indebtedness” means for purposes of
Section 4.12 only, as to any Person at a particular time, without duplication, all of the following, whether or not included as Indebtedness or liabilities in accordance with GAAP: 

(a) all obligations of such Person for borrowed money and all obligations of such Person evidenced by bonds, debentures, notes, loan
agreements or other similar instruments; 

  
 11 

 (b) all direct or contingent obligations of such Person arising under letters of credit
(including standby and commercial), bankers’ acceptances, bank guaranties, surety bonds and similar instruments; 
 (c) net
obligations of such Person under any Swap Contract; 
 (d) all obligations of such Person to pay the deferred purchase price of
property or services (other than trade accounts and accrued expenses payable in the ordinary course of business, obligations in respect of licenses and operating leases, payroll liabilities and deferred compensation and any purchase price
adjustments, royalties, earn-out, milestone payment, contingent payment of a similar nature in connection with any acquisition or license or collaboration agreement); 
 (e) Indebtedness (excluding prepaid interest thereon) secured by a lien on property owned or being purchased by such Person (including Indebtedness arising under conditional sales or other title retention
agreements but excluding trade accounts and accrued expenses payable in the ordinary course of business and licenses and operating leases), whether or not such Indebtedness shall have been assumed by such Person or is limited in recourse;

 (f) all Attributable Indebtedness in respect of Capital Leases and Synthetic Lease Obligations; 

(g) all obligations in respect of Redeemable Equity; and 
 (h) all Guarantees of such Person in respect of any of the foregoing. 

“Indenture” means this Indenture, as amended or supplemented from time to time in accordance with the terms hereof.

 “Issue Date” means September 17, 2012. 

“Last Reported Sale Price” of the Common Stock (or any other security for which a Last Reported Sale Price must be
determined) on any Trading Day means the closing sale price per share of the Common Stock (or such other security) (or, if no closing sale price is reported, the average of the last bid price and the last ask price or, if more than one in either
case, the average of the average last bid price and the average last ask price) on that Trading Day as reported in composite transactions for the principal United States national or regional securities exchange on which the Common Stock (or such
other security) is traded. If the Common Stock (or such other security) is not listed for trading on a United States national or regional securities exchange on the relevant Trading Day, the “Last Reported Sale Price” of the Common Stock
(or such other security) will be the last quoted bid price per share of the Common Stock (or such other security) in the over-the-counter market on the relevant Trading Day as reported by Pink OTC Markets Inc. or a similar organization. If the
Common Stock (or such other security) is not so quoted, the “Last Reported Sale Price” will be the average of the mid-point of the last bid price and the last ask price per share of the Common Stock (or such other security) on the relevant
Trading Day from each of at least three nationally recognized independent investment banking firms selected by the Company for this purpose. Notwithstanding the foregoing, if the Last Reported Sale Price must be determined on any Trading Day for a
Unit of Reference 

  
 12 

 
Property, the Last Reported Sale Price on such Trading Day for such Unit of Reference Property will be determined in good faith by the Board of Directors. 

“Notes” means any of the Company’s 5.00% Convertible Senior Notes due 2017 issued under this Indenture. 

“Officer” means the Chairman of the Board, the Vice Chairman, the Chief Executive Officer, the President, the Chief
Financial Officer, any Executive Vice President, any Senior Vice President, any Vice President, the Treasurer, Controller or the Secretary or Assistant Secretary of the Company. 

“Officer’s Certificate” means a written certificate containing the information specified in Sections 12.03 and
12.04 hereof, signed in the name of the Company by any Officer, and delivered to the Trustee; provided, that, if such certificate is given pursuant to Section 4.05 hereof, (i) the Officer signing such certificate must be the
principal financial, principal executive or principal accounting Officer of the Company and (ii) such certificate need not contain the information specified in Sections 12.03 and 12.04 hereof. 

“Open of Business” means 9:00 a.m., New York City time. 

“Opinion of Counsel” means a written opinion containing the information specified in Sections 12.03 and 12.04 hereof,
from legal counsel. The counsel may be an employee of, or counsel to, the Company, or may be other counsel reasonably satisfactory to the Trustee. 
 “Permitted Debt” means, without duplication, each of the following: 
 (a) Indebtedness incurred by the Company or any of the Subsidiaries pursuant to one or more Credit Facilities in an aggregate principal amount not to exceed $50.0 million outstanding at any time;

 (b) Indebtedness in respect of the Notes; 
 (c) any unsecured Indebtedness of the Company issued in exchange for, or the net proceeds of which are used to renew, refund, refinance, replace or discharge the Notes; provided that (a) the
aggregate principal amount of such Indebtedness does not exceed the aggregate principal amount of the Notes so renewed, refunded, refinanced, replaced or discharged (plus all accrued and unpaid interest and premiums thereon), (b) the Notes are
renewed, refunded, refinanced, replaced or discharged substantially concurrently with receipt of the proceeds from such Indebtedness and (c) the scheduled maturity date of such Indebtedness is after the 91st day immediately following the
Maturity Date; 
 (d) Subordinated Indebtedness incurred by the Company or any of the Subsidiaries; 

(e) other Indebtedness incurred by the Company or the Subsidiaries outstanding on the Issue Date other than the Indebtedness under the
Credit Facilities or otherwise specified under any of the other clauses of this definition of Permitted Debt, and any refinancing of such Indebtedness or any other Indebtedness permitted under the Indenture (but not otherwise

  
 13 

 
constituting Permitted Debt); provided that the principal amount of any such refinancing Indebtedness shall not exceed the principal amount of the Indebtedness being refinanced plus
accrued and unpaid interest, prepayment, tender or other premiums and reasonable fees, costs and expenses incurred in connection with such refinancing; 
 (f) hedging obligations (including obligations under Swap Contracts) entered into in the ordinary course of business by the Company or the Subsidiaries and not for speculative purposes; 

(g) intercompany Indebtedness among the Company and any of the Subsidiaries; 

(h) Indebtedness incurred as a result of endorsing negotiable instruments received in the ordinary course of business; 

(i) Indebtedness in respect of letters of credit, bank guarantees, surety or performance bonds and similar instruments issued for the
Company’s account or the account of any of the Subsidiaries in order to provide security for (A) workers’ compensation claims, payment obligations in connection with self-insurance or similar requirements, and (B) bids, trade
contracts, leases, statutory obligations, surety and appeal bonds, performance bonds and obligations of a like nature; 
 (j)
Indebtedness arising from agreements of the Company or any of the Subsidiaries providing for the indemnification, adjustment of purchase price, earn-out, royalty, milestone or similar obligations, in each case assumed with the acquisition or
disposition of any business; 
 (k) additional Indebtedness incurred by the Company or any of the Subsidiaries in an aggregate
principal amount not to exceed $1.0 million at any one time outstanding; 
 (l) Indebtedness incurred by the Company or any of
the Subsidiaries in the ordinary course of business under any commercial credit card program; 
 (m) Indebtedness incurred by
the Company or any of the Subsidiaries consisting of the financing of insurance premiums in the ordinary course of business; 

(n) Indebtedness incurred by the Company or any of the Subsidiaries in the ordinary course of business arising from treasury, depository,
over-draft and cash management services; provided that any such Indebtedness shall be repaid in full within five business days of the incurrence thereof; and 
 (o) any Guarantees by the Company or any of the Subsidiaries of Indebtedness of the Company or the Subsidiaries not otherwise prohibited under the Indenture. 

“Person” means any individual, corporation, limited liability company, partnership, joint venture, association,
joint-stock company, trust, unincorporated organization, or government or any agency or political subdivision thereof. 

  
 14 

 “Preliminary Offering Memorandum” means the Preliminary Offering Memorandum
relating to the offering of the Notes dated September 10, 2012. 
 “Pricing Termsheet” means the Pricing
Termsheet attached to the Purchase Agreement as Schedule II thereto. 
 “Purchase Agreement” means the
purchase agreement, dated September 11, 2012, between the Company and Jefferies & Company, Inc. and J.P. Morgan Securities LLC, as representatives of the several Initial Purchasers listed in Schedule I thereto. 

“Redeemable Equity” means any Equity Interest of the Company or any of the Subsidiaries that by its terms (or by terms
of any security into which it is convertible or for which it is exchangeable), or otherwise (including by the passage of time or the happening of an event), is required to be redeemed, is redeemable at the option of the holder thereof in whole or in
part (including by operation of a sinking fund), or is convertible or exchangeable for Indebtedness of such Person (with a scheduled maturity prior to the 91st day immediately following the Maturity Date) at the option of the holder thereof, in
whole or in part, at any time prior to the 91st day immediately following the Maturity Date (other than upon the occurrence of a change of control or asset sale); provided, however, that only the portion of such Equity Interest which is
required to be redeemed, is so convertible or exchangeable or is so redeemable at the option of the holder thereof before such date will be deemed to be Redeemable Equity. However, Redeemable Equity will not include any common stock issued by the
Company or the Subsidiaries to its employees or directors that is subject to repurchase by the Company or the Subsidiaries pursuant to the terms of any employment agreement, benefit plan or other arrangement. The amount of Redeemable Equity deemed
to be outstanding at any time for purposes of the Indenture will be the maximum amount that the Company or any of the Subsidiaries may become obligated to pay upon the maturity of, or pursuant to any mandatory redemption provisions of, such
Redeemable Equity or portion thereof, exclusive of accrued dividends. 
 “Regulation S-X” means Regulation S-X
promulgated under the Securities Act, as amended. 
 “Restricted Note” means each Note that is deemed to bear
or otherwise required under Section 2.10 to bear, the Restricted Notes Legend and the Restricted Notes CUSIP. 

“Restricted Notes CUSIP” means CUSIP number 817337 AA6. 

“Restricted Notes Legend” means a legend in the form set forth in Exhibit A hereto, or any other similar legend
indicating the restricted status of the Notes under Rule 144. 
 “Restricted Stock CUSIP” means CUSIP number
817337 504. 
 “Restricted Stock Legend” means a legend in the form set forth in Exhibit D hereto or any
other similar legend indicating the restricted status of the Common Stock under Rule 144. 
 “Rule 144” means
Rule 144 under the Securities Act (or any successor provision), as it may be amended from time to time. 

  
 15 

 “Rule 144A” means Rule 144A under the Securities Act (or any successor
provision), as it may be amended from time to time. 
 “SEC” means the Securities and Exchange Commission, or
any successor thereto. 
 “Securities Act” means the Securities Act of 1933, as amended. 

“Significant Subsidiary” means any Subsidiary that is a “significant subsidiary” of the Company within the
meaning of Rule 1-02(w) of Regulation S-X promulgated under the Exchange Act; provided that, in the case of a Subsidiary that meets the criteria of clause (3) of the definition thereof but not clause (1) or (2) thereof, such
Subsidiary shall not be deemed to be a Significant Subsidiary unless such Subsidiary’s income from continuing operations before income taxes, extraordinary items and cumulative effect of a change in accounting principle exclusive of amounts
attributable to any non-controlling interests for the last completed fiscal year prior to the date of such determination exceeds $10,000,000. 
 “Stock Price” means, for any Make-Whole Fundamental Change, (i) if the holders of the Common Stock receive only cash in consideration for their shares of Common Stock in such
Make-Whole Fundamental Change and such Make-Whole Fundamental Change is of the type described in clause (ii) of the definition of Fundamental Change, the amount of cash paid per share of the Common Stock in such Make-Whole Fundamental Change,
and (ii) otherwise, the average of the Last Reported Sales Price of the Common Stock over the five consecutive Trading Day period ending on, and including, the Trading Day immediately preceding the Make-Whole Fundamental Change Effective Date
for such Make-Whole Fundamental Change. 
 “Subordinated Indebtedness” means (a) any Indebtedness of the
Company that is by its terms expressly subordinated in right of payment to the Notes, and (b) any Indebtedness of any of the Subsidiaries that has expressly guaranteed the payment and performance of the Company’s obligations under the
Notes provided such Indebtedness is expressly subordinated in right of payment to such Guarantee, in each case with a scheduled maturity after the 91st day immediately following the Maturity Date. 

“Subsidiary” means a Person more than 50% of the outstanding Voting Stock of which is owned, directly or indirectly, by
the Company or by one or more other Subsidiaries of the Company, or by the Company and one or more other Subsidiaries of the Company. 
 “Swap Contract” means (a) any and all rate swap transactions, basis swaps, credit derivative transactions, forward rate transactions, commodity swaps, commodity options, forward
commodity contracts, equity or equity index swaps or options, bond or bond price or bond index swaps or options or forward bond or forward bond price or forward bond index transactions, interest rate options, forward foreign exchange transactions,
cap transactions, floor transactions, collar transactions, currency swap transactions, cross-currency rate swap transactions, currency options, spot contracts, or any other similar transactions or any combination of any of the foregoing (including
any options to enter into any of the foregoing), whether or not any such transaction is governed by or subject to any master agreement, and (b) any and all transactions of any kind, and the related confirmations, which are subject to the terms
and conditions of, or governed by, any form of master agreement published by the International 

  
 16 

 
Swaps and Derivatives Association, Inc., any International Foreign Exchange Master Agreement, or any other master agreement (any such master agreement, together with any related schedules, a
“master agreement”), including any such obligations or liabilities under any master agreement. 

“TIA” means the Trust Indenture Act of 1939 as in effect on the Issue Date; provided, however, that if the
TIA is amended after such date, TIA means, the TIA as so amended. 
 “Trading Day” means a day on which
(i) trading in the Common Stock generally occurs on The NASDAQ Global Select Market or, if the Common Stock is not then listed on The NASDAQ Global Select Market (or the Last Reported Sale Price must be determined for another security), on the
principal other United States national or regional securities exchange on which the Common Stock (or such other security) is then listed or, if the Common Stock (or such other security) is not then listed on a United States national or regional
securities exchange, on the principal other market on which the Common Stock (or such other security) is then traded, and (ii) a Last Reported Sale Price of the Common Stock (or such other security) is available on such securities exchange or
market. If the Common Stock (or such other security) is not so listed or traded, “Trading Day” means a Business Day. 

“Transfer” means, with respect to any Restricted Note or share of Common Stock that bears, or is required to bear, the
Restricted Stock Legend, any sale, pledge, transfer, loan, hypothecation or other disposition of such Restricted Note or share of Common Stock, as the case may be. 
 “Transfer Agent” means, initially Computershare Investor Services LLC, in its capacity as the transfer agent for the transfer agent for the Common Stock, and any successor entity acting
in such capacity. 
 “Trust Officer” means, when used with respect to the Trustee, any officer within the
corporate trust department of the Trustee (or any successor group of the Trustee), including any vice president, assistant vice president, assistant secretary, assistant treasurer, trust officer or any other officer of the Trustee who customarily
performs functions similar to those performed by Persons who at the time shall be such officers, respectively, whom such matter is referred because of his or her knowledge of and familiarity with the particular subject and who shall have direct
responsibility for the administration of this Indenture. 
 “Trustee” means the party named as the
“Trustee” in the first paragraph of this Indenture until a successor replaces it pursuant to the applicable provisions of this Indenture and, thereafter, means such successor. The foregoing sentence will likewise apply to any such
subsequent successor or successors. 
 “Unit of Reference Property” means the amount and kind of Reference
Property that a holder of one share of the Common Stock would receive in a Merger Event; provided, however, that if, in any Merger Event, the holders of the Common Stock may exchange each of their shares of Common Stock for more than
one amount and kind of Reference Property and may elect which amounts and kinds of Reference Property they receive, a Unit of Reference Property will consist of the weighted average of the amounts and kinds of Reference Property received by holders
of the Common Stock that affirmatively make such election. 

  
 17 

 “Unrestricted Notes CUSIP” means CUSIP number 817337 AB4. 

“Unrestricted Stock CUSIP” means CUSIP number 817337 405. 

“Voting Stock” of a Person means Capital Stock of such Person of the class or classes pursuant to which the holders
thereof have the general voting power under ordinary circumstances to elect at least a majority of the board of directors, managers or trustees of such Person (irrespective of whether or not at the time Capital Stock of any other class or classes
will have or might have voting power by reason of the happening of any contingency). 
 Section 1.02 Other
Definitions. 
  

			
	 Term Section:
	  	 Defined in:

	“Act”	  	1.05
	“Additional Interest”	  	4.04(a)
	“Additional Shares”	  	10.07(a)
	“Agent Members”	  	2.02(c)
	“Conversion Agent”	  	2.06(a)
	“Conversion Date”	  	10.02(a)
	“Conversion Notice”	  	10.02(a)
	“Effective Date”	  	10.05(l)
	“Event of Default”	  	6.01
	“Ex-Dividend Date”	  	10.05(l)
	“Expiration Date”	  	10.05(e)
	“Extension Fee”	  	6.04(a)
	“Fundamental Change Notice”	  	3.02(a)
	“Fundamental Change Notice Date”	  	3.02(a)
	“Fundamental Change Repurchase Date”	  	3.01(c)
	“Fundamental Change Repurchase Notice”	  	3.03(a)
	“Fundamental Change Repurchase Price”	  	3.01(b)
	“Interest Payment Date”	  	2.04(a)
	“Make-Whole Fundamental Change”	  	10.07(a)
	“Make-Whole Fundamental Change Effective Date”	  	10.07(b)
	“Maturity Date”	  	2.04(a)
	“Merger Event”	  	10.08(a)
	“Merger Successor Corporation”	  	10.08(a)
	“Paying Agent”	  	2.06(a)
	“Redemption Date”	  	11.02(c)
	“Redemption Notice”	  	11.03
	“Redemption Notice Date”	  	11.03
	“Redemption Price”	  	11.02(b)
	“Reference Property”	  	10.08(a)
	“Register”	  	2.06(a)
	“Registrar”	  	2.06(a)
	“Regular Record Date”	  	2.04(a)

  
 18 

			
	 Term Section:
	  	 Defined in:

	“Reorganization Event”	  	5.01
	“Reorganization Successor Corporation”	  	5.01(a)
	“Reporting Event of Default”	  	6.04(a)
	“Resale Restriction Termination Date”	  	2.10(b)(i)
	“Special Record Date”	  	2.04(d)
	“Spin-Off”	  	10.05(c)
	“Temporary Notes”	  	2.12
	“Valuation Period”	  	10.05(c)

 Section 1.03 [Reserved]. 

Section 1.04 Rules of Construction. 
 (1) a term has the meaning assigned to it; 
 (2) an accounting term not otherwise
defined has the meaning assigned to it and will be construed in accordance with GAAP; 
 (3) “or” is not
exclusive; 
 (4) “including” means including, without limitation; 

(5) “may” is not mandatory and shall not create any limitation; 

(6) words in the singular include the plural, and words in the plural include the singular; 

(7) all references to $, dollars, cash payments or money refer to United States currency; and 

(8) unless the context requires otherwise, all references to payments of interest on the Notes will include any Additional Interest
payable pursuant to Section 4.04 hereof and any Extension Fee payable pursuant to Section 6.04 hereof 

Section 1.05 Acts of Holders. 
 Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by Holders may be embodied in and evidenced by one or more
instruments of substantially similar tenor signed by such Holders in person or by an agent duly appointed in writing; and, except as herein otherwise expressly provided, such action will become effective when such instrument or instruments are
delivered to the Trustee and to the Company. Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein sometimes referred to as the “Act” of Holders signing such instrument or instruments.
Proof of execution of any such instrument or of a writing appointing any such agent will be sufficient for any purpose of this Indenture and conclusive in favor of the Trustee and the Company, if made in the manner provided in this
Section 1.05. 

  
 19 

 The fact and date of the execution by any Person of any such instrument or writing may be
proved by the affidavit of a witness of such execution or by a certificate of a notary public or other officer authorized by law to take acknowledgments of deeds, certifying that the individual signing such instrument or writing acknowledged to such
officer the execution thereof. Where such execution is by a signer acting in a capacity other than such signer’s individual capacity, such certificate or affidavit will also constitute sufficient proof of such signer’s authority. The fact
and date of the execution of any such instrument or writing, or the authority of the Person executing the same, may also be proved in any other manner that the Trustee deems sufficient. 

The ownership of the Notes shall be proved by the Register. 
 Any request, demand, authorization, direction, notice, consent, waiver or other Act of the Holder of any Note will bind every future Holder of the same Note and the Holder of every Note issued upon the
registration of transfer thereof or in exchange therefor or in lieu thereof in respect of anything done, omitted or suffered to be done by the Trustee, the Company, the Paying Agent, the Conversion Agent or the Registrar in reliance thereon, whether
or not notation of such action is made upon such Note. 
 If the Company will solicit from the Holders any request, demand,
authorization, direction, notice, consent, waiver or other Act, the Company may, at its option, by or pursuant to a Board Resolution, fix in advance a record date for the determination of Holders entitled to give such request, demand, authorization,
direction, notice, consent, waiver or other Act, but the Company will have no obligation to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other Act may be given before or after such
record date, but only the Holders of record at the Close of Business on such record date will be deemed to be Holders for the purposes of determining whether Holders of the requisite proportion of outstanding Notes have authorized or agreed or
consented to such request, demand, authorization, direction, notice, consent, waiver or other Act, and for that purpose the outstanding Notes will be computed as of such record date; provided that no such authorization, agreement or consent
by the Holders on such record date will be deemed effective unless it will become effective pursuant to the provisions of this Indenture not later than six months after the record date. 

ARTICLE 2 

THE NOTES 

Section 2.01 Designation, Amount and Issuance of Notes. 

(a) The Notes will be designated as “5.00% Convertible Senior Notes due 2017.” The aggregate principal amount of Notes that
initially may be authenticated and delivered under this Indenture is limited to $130,000,000. From time to time, the Company may issue and execute, and the Trustee may authenticate, Notes delivered upon registration of transfer of, or in exchange
for, or in lieu of, other Notes pursuant to Sections 2.09, 2.11, 2.12, 3.06 and 10.02(c) hereof. 

  
 20 

 Section 2.02 Form of Notes. 

(a) General. The Notes will be substantially in the form of Exhibit A hereto, but may include any notations, legends or
endorsements required by any applicable law (or regulation promulgated thereunder), stock exchange rule or usage, or any insertions, omissions or other variations otherwise permitted or required by this Indenture. Whenever any such notation, legend
or endorsement, or any such insertion, omission or other variation is applicable to a Note, the Company will provide such notation, legend or endorsement, or such insertion, omission or other variation to the Trustee in writing. 

Each Note will bear a Trustee’s certificate of authentication substantially in the form set forth in Exhibit A hereto.

 Notes that are Global Notes will bear the Global Notes Legend and the “Schedule of Exchanges of Interests in the Global
Note” attached thereto. 
 Notes that are Restricted Notes will bear the Restricted Notes Legend. 

The terms and provisions contained in the Notes will constitute, and are hereby expressly made, a part of this Indenture and, to the
extent applicable, the Company and the Trustee, by their execution and delivery of this Indenture, expressly agree to such terms and provisions and to be bound thereby. However, to the extent that any provision of any Note conflicts with the express
provisions of this Indenture, the provisions of this Indenture will govern and control. 
 (b) Initial and Subsequent
Notes. The Notes initially will be issued in global form, registered in the name of Cede & Co., as the nominee of the Depositary, and deposited with the Trustee, at its Corporate Trust Office, as custodian for the Depositary. Except to
the extent provided in Section 2.09(c) hereof, all Notes will be represented by one or more Global Notes. 
 (c)
Global Notes. Each Global Note will represent the aggregate principal amount of then outstanding Notes endorsed thereon and provide that it represents such aggregate principal amount of then outstanding Notes, which aggregate
principal amount may, from time to time, be reduced or increased to reflect transfers, exchanges, conversions, redemptions or repurchases by the Company. 
 Only the Trustee, or the custodian holding such Global Note for the Depositary, at the direction of the Trustee, may endorse a Global Note to reflect the amount of any increase or decrease in the
aggregate principal amount of then outstanding Notes represented thereby, and whenever the Holder of a Global Note delivers instructions to the Trustee to increase or decrease the aggregate principal amount of then outstanding Notes represented by a
Global Note in accordance with Section 2.09 hereof, the Trustee, or the custodian holding such Global Note for the Depositary, at the direction of the Trustee, will endorse such Global Note to reflect such increase or decrease in the aggregate
principal amount of then outstanding Notes represented thereby. None of the Trustee, the Company or any agent of the Trustee or the Company will have any responsibility or bear any liability for any aspect of the records relating to, or payments
made on account of, the ownership of any beneficial interest in a Global Note or with respect to maintaining, supervising or reviewing any records relating to such beneficial interest. 

  
 21 

 Neither any member of, or participant in, the Depositary (collectively, the “Agent
Members”) nor any other Person on whose behalf an Agent Member may act will have any rights under this Indenture with respect to any Global Note or under such Global Note, and the Company, the Trustee and any agent of the Company or the
Trustee, may, for all purposes, treat the Depositary, or its nominee, if any, as the absolute owner and Holder of such Global Note. 
 The Holder of a Global Note may grant proxies and otherwise authorize any Person, including Agent Members and Persons that may hold interests through Agent Members, to take any action that Holders are
entitled to take under this Indenture or the Notes, and, notwithstanding the foregoing, nothing herein will prevent the Company, the Trustee or any agent of the Company or the Trustee from giving effect to any written certification, proxy or other
authorization furnished by the Depositary or such nominee, as the case may be, or impair, as between the Depositary, its Agent Members and any other Person on whose behalf an Agent Member may act, the operation of customary practices of such Persons
governing the exercise of the rights of a Holder of any interest in any Note. 
 Neither the Trustee nor any of its agents shall
have any responsibility or liability for any actions taken or not taken by the Depositary. 
 Section 2.03 Denomination
of Notes. 
 The Notes will be issuable in registered form without coupons in denominations of $1,000 principal amount and
integral multiples of $1,000 in excess thereof. 
 Section 2.04 Payments. 

(a) General. 
 (i) Payment at Maturity. Unless earlier paid or deemed paid pursuant to any of Sections 3.05, 10.03 or 11.06 hereof, the Notes will mature on October 1, 2017 (the “Maturity
Date”) and, on the Maturity Date, the Company will pay each Holder of Notes $1,000 in cash for each $1,000 principal amount of Notes held, together with accrued and unpaid interest on such Notes to, but not including, the Maturity Date.

 (ii) Payment of Interest. Each Note will accrue interest at a rate equal to 5.00% per annum from the Issue Date
or from the most recent date to which interest has been paid or duly provided for, subject to the provisions of clause (d) of this Section 2.04, the date the principal amount of such Note is paid or deemed paid, as the case may be,
pursuant to clause (i) of this Section 2.04(a) or any of Sections 3.05, 10.03 or 11.06 hereof. 
 Interest will be
payable semi-annually in arrears in cash on April 1 and October 1 of each year (each, an “Interest Payment Date”), beginning April 1, 2013, to the Holder of each such Note as of the Close of Business on the
March 15 or September 15, as the case may be, immediately preceding the applicable Interest Payment Date (each such date, a “Regular Record Date”), regardless of whether such Note is converted, repurchased or redeemed
after such Regular Record Date. Interest will be computed on the basis of a 360-day year comprised of twelve 30-day months. 

  
 22 

 (iii) Method of Payment. The Company will pay the principal of, the Fundamental Change
Repurchase Price or the Redemption Price for, and the interest on, any Global Note to the Depositary by wire transfer of immediately available funds on the relevant payment date. 

The Company will pay the principal of, the Fundamental Change Repurchase Price or Redemption Price for, and any interest due on
the Maturity Date on, any Definitive Note in cash to the applicable Holder of such Note at the office of the Paying Agent on the relevant payment date.  
 The Company will pay interest on any Definitive Note (except interest due on the Maturity Date) to the applicable Holder of such Note (i) if such Holder holds $5,000,000 or less aggregate principal
amount of Notes, by check mailed to such Holder’s registered address, and (ii) if such Holder holds more than $5,000,000 aggregate principal amount of Notes, (A) by check mailed to such Holder’s registered address or, (B) if
such Holder delivers to the Registrar a written request that the Company make such payments by wire transfer to an account of such Holder within the United States, for each interest payment corresponding to each Regular Record Date occurring during
the period beginning on the date on which such Holder delivered such request and ending on the date, if any, on which such Holder delivers to the Registrar a written instruction to the contrary, by wire transfer of immediately available funds to the
account specified by such Holder. 
 (b) Interest Rights Preserved. Subject to the provisions of Section 2.04(d)
hereof, and, to the extent applicable, Sections 2.09 and 2.11 hereof, each Note delivered under this Indenture upon registration of transfer of, or in exchange for, or in lieu of, any other Note will carry any rights to the payment and accrual of
interest that were carried by the relevant surrendered Note, Notes, or portion(s) thereof. 
 (c) Additional Interest;
Extension Fee. Pursuant to Section 4.04 hereof, in certain circumstances, Additional Interest will accrue on the Notes. Pursuant to Section 6.04 hereof, in certain circumstances, the Company may, at its election, be obligated to pay
Holders the Extension Fee. Unless the context requires otherwise, all references in this Indenture to interest on the Notes will include such Additional Interest and Extension Fee. 

(d) Defaulted Amounts. Any Defaulted Amount will forthwith cease to be payable to the Holder of such Note on the relevant payment
date by virtue of its having been due such payment on such payment date, but will accrue interest at the per annum rate borne by the Notes from, and including, such payment date and to, but excluding, the date on which such Defaulted Amount is paid
by the Company in accordance with either clause (i) or (ii) below. 
 (i) The Company may elect to pay any Defaulted
Amount to the Persons in whose names the Notes (or their respective predecessor Notes) are registered at the Close of Business on a special record date for the payment of such Defaulted Amount (a “Special Record Date”) fixed in
accordance with the following procedures: 
 (A) At least 30 days before the date on which the Company proposes
to pay such Defaulted Amounts, the Company will deliver to the Trustee written 

  
 23 

 
notice of (I) the proposed payment date for such Defaulted Amounts and (II) the aggregate amount of such Defaulted Amounts. 

(B) Simultaneously with delivering such notice to the Trustee, the Company will either (I) deposit with the Trustee
an amount of money, in immediately available funds, equal to the aggregate amount of such Defaulted Amounts, or (II) take other actions that the Trustee deems reasonably satisfactory to ensure that an amount of money, in immediately available funds,
equal to the aggregate of such Defaulted Amounts will be deposited with the Trustee by 11:00 a.m., New York City time, on the day that is five Business Days prior to the proposed payment date, and in either case, upon receipt of such money, the
Trustee will hold such money in trust for the benefit of the Persons entitled to such Defaulted Amounts pursuant to this Section 2.04(d)(i). 
 (C) Upon (i) receipt of such notice and (ii) the Company’s depositing such money or taking such other actions reasonably satisfactory to the Trustee, the Company will promptly fix a Special
Record Date for the payment of such Defaulted Amounts, which Special Record Date will be not more than 15 calendar days and not less than 10 days prior to the proposed payment date, and notify the Trustee of the Special Record Date. The Trustee will
then, in the name and at the expense of the Company, deliver notice to each Holder specifying such Special Record Date and the date on which such Defaulted Amounts will be paid by the Company. 

(D) After such notice has been delivered by the Trustee, such Defaulted Amounts and Default Interest thereon will be paid
to the Persons in whose names the Notes (or their respective predecessor Notes) are registered at the Close of Business on the Special Record Date specified in such notice and such Defaulted Amounts thereon will no longer be payable pursuant to the
following clause (ii) of this Section 2.04(d)(i). 
 (ii) The Company may pay any Defaulted Amounts in any other
lawful manner that is not inconsistent with the requirements of any securities exchange or automated quotation system on which the Notes are then listed (or, if applicable, have been listed) or designated for issuance, and upon such notice as may be
required by such exchange or automated quotation system, if, after notice given by the Company to the Trustee of the proposed payment pursuant to this clause, such manner of payment will be deemed practicable by the Trustee. 

Section 2.05 Execution and Authentication. 
 (a) In General. A Note will be valid only if executed by the Company and authenticated by the Trustee. 
 (b) Execution. A Note will be deemed to have been executed by the Company when an Officer signs such Note on behalf of the Company. The Officer’s signature may be manual or facsimile, and the
validity of such Officer’s signature will not turn on whether such signatory remains an Officer at the time the Trustee authenticates such Note. 

  
 24 

 (c) Authentication. A Note will be deemed authenticated when an authorized signatory
of the Trustee manually signs the certificate of authentication on such Note. An authorized signatory of the Trustee will manually sign the certificate of authentication on a Note only if (i) the Company delivers such Note to the Trustee,
(ii) such Note is validly executed by the Company in accordance with Section 2.05(b) hereof, and (iii) the Company delivers, before or with such Note, a Company Order setting forth (A) a request that the Trustee authenticate such
Note; (B) the principal amount of such Note; (C) the name of the Holder of such Note, (D) the date on which such Note is to be authenticated; and (E) any insertions, omissions or other variations, notations, legends or
endorsements permitted under Section 2.02 hereof and applicable to such Note. If the Company Order also specifies that the Trustee must deliver such Note to the Holder or the Depositary, the Trustee will promptly deliver such Note in accordance
with such Company Order. 
 The Trustee may appoint an authenticating agent. If the Trustee appoints an authenticating agent and
such authenticating agent is reasonably acceptable to the Company, such authenticating agent may authenticate a Note whenever the Trustee may authenticate such Note; provided, however, that such authenticating agent may not
authenticate any Notes pursuant to Section 2.12 hereof. For purposes of this provision, each reference in this Indenture to authentication by the Trustee will be deemed to include authentication by an authenticating agent, and an authenticating
agent will have the same rights to deal with the Company as the Trustee would have if it were performing the duties that the authentication agent was validly appointed to undertake. 

Section 2.06 Registrar, Paying Agent and Conversion Agent. 

(a) General. The Company will maintain an office or agency in the continental United States where Notes may be presented for
registration of transfer or for exchange (the “Registrar”), an office or agency where the Notes may be presented for payment, repurchase or redemption (the “Paying Agent”), an office or agency where the Notes may be
presented for conversion (the “Conversion Agent”) and an office or agency where notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be served. 

The Registrar will keep a register for the recordation of, and will record, the names and addresses of Holders, the Notes held by each
Holder and the transfer, exchange, repurchase, redemption and conversion of Notes (the “Register”). The entries in the Register will be conclusive, and the parties may treat each Person whose name is recorded in the Register
pursuant to the terms hereof as a Holder hereunder for all purposes of this Indenture. The Register will be in written form or in any form capable of being converted into written form within a reasonably prompt period of time. 

The Company may have one or more registrars, one or more paying agents, one or more conversion agents and one or more places where
notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be served. Before appointing any Registrar, Paying Agent or Conversion Agent that is not otherwise a party to this agreement, the Company will enter into
an appropriate agency agreement with such Registrar, Paying Agent or Conversion Agent, as the case may be, which agency agreement will implement the provisions of this Indenture that relate to such replacement or additional registrar, paying agent
or conversion 

  
 25 

 
agent, as the case may be. The term Registrar includes any additional registrars named pursuant to this Indenture. The term Paying Agent includes any additional paying agent named pursuant to
this Indenture. The term Conversion Agent includes any additional conversion agent named pursuant to this Indenture. 
 (b)
Initial Designations. The Company initially appoints the Trustee as each of the Registrar, the Paying Agent, Conversion Agent and the Notes initially may be presented for registration of transfer or for exchange, payment, repurchase,
redemption and conversion to the Trustee, in its capacity as the Registrar, Paying Agent or Conversion Agent, as the case may be, at the Corporate Trust Office. Notices and demands to, or upon, the Company with respect to the Notes and this
Indenture may be served at the Corporate Trust Office. 
 (c) Removal, Resignation and Replacement. The Company may
remove any Registrar, Paying Agent or Conversion Agent by delivering written notice to the Trustee and to such Registrar, Paying Agent or Conversion Agent; provided, however, that no such removal will become effective unless
(i) after such removal, at least one Registrar, Paying Agent and Conversion Agent will remain; (ii) a successor has accepted appointment as Registrar, Paying Agent or Conversion Agent, as the case may be, the Company and such successor
have entered into an agency agreement in accordance with Section 2.06(a) hereof, and the Company has delivered written notice of such appointment and a copy of such agency agreement to the Trustee, or (iii) the Company has delivered
written notice to the Trustee that the Trustee will serve as the successor Registrar, Paying Agent or Conversion Agent, as the case may be, in accordance with Section 2.06(d) hereof; and provided, further, that the right to effect
any such change or removal in no way relieves the Company of its obligation to maintain a Registrar, Paying Agent and Conversion Agent in the continental United States. The Company may also change the place where notices and demands to, or upon, the
Company with respect to the Notes and this Indenture may be served, or reduce the number of such places; provided, however, that the right to effect any such change or reduction in no way relieves the Company of its obligation to
maintain a place in the continental United States where notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be served. 
 In addition, the Registrar, Paying Agent or Conversion Agent may resign at any time by delivering written notice of such resignation to each of the Company and the Trustee; provided,
however, that if the Trustee is serving as Registrar, Paying Agent or Conversion Agent, the Trustee may resign from such capacity only if it also resigns as Trustee in accordance with Section 7.07 hereof. If, after any such resignation,
at least one Registrar, Paying Agent and Conversion Agent does not remain, the Trustee will immediately be deemed to serve such empty office or agency in accordance with Section 2.06(d) hereof. 

(d) Failure to Maintain an Office or Agency. If the Company fails to maintain in the continental United States, a Registrar,
Paying Agent, Conversion Agent or place where notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be served, the Trustee will act as the Registrar, Paying Agent, Conversion Agent, or place, as the case may
be, and the office where the Notes may be presented for registration of transfer or for exchange, presented for payment, repurchase or redemption or surrendered for conversion, or place where notices and demands to, or upon, the Company with respect
to the Notes and this 

  
 26 

 
Indenture may be served, as the case may be, will be the Corporate Trust Office. In each such case, the Trustee will be entitled to compensation for such action pursuant to Section 7.06
hereof. 
 (e) Notices. Promptly upon the effectiveness of any removal or subsequent appointment of a Registrar, Paying
Agent or Conversion Agent, or upon any change in the location of the office of any Registrar, Paying Agent or Conversion Agent, or of the place where notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be
served, the Company will deliver to each Holder notice of such removal, appointment or change in location, as the case may be, which notice will include a brief description of the removal, appointment or change in location, as the case may be, and
list the name and address of each continuing (and newly appointed, if applicable) Registrar, Paying Agent and Conversion Agent and place where notices and demands to, or upon, the Company with respect to the Notes and this Indenture may be served.

 Section 2.07 Money and Securities Held in Trust. 

Except as otherwise provided herein, by no later than 11:00 a.m., New York City time, on each due date for a payment on any Note, the
Company will deposit with the Paying Agent an amount of money in immediately available funds, if deposited on the due date sufficient to make such payment when due. 
 The Company will require that each Paying Agent (other than the Trustee, if the Trustee is a Paying Agent) agree in writing that it will (i) segregate all money and securities it holds for making
payments with respect to the Notes; (ii) hold such money and securities in trust for the benefit of Holders; and (iii) notify the Trustee, in writing, as promptly as practicable, if the Company defaults in making any payment on the Notes.

 If any such Default has occurred and is continuing, the Paying Agent will, upon receiving a written request from the Trustee,
forthwith pay to the Trustee all of the money and securities it holds in trust. In addition, at any time, the Company may require a Paying Agent to pay all money and securities that it holds for making payments with respect to the Notes to the
Trustee and to account for any money and securities it has disbursed. After delivering all of such money and securities to the Trustee pursuant to this Section 2.07, the Paying Agent will have no further liability for such money and securities.

 Section 2.08 Holder Lists. 
 The Trustee will preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses of Holders. If the Trustee is not the Registrar, the Company
shall furnish to the Trustee, promptly after each Record Date, and at such other times as the Trustee may request in writing, a list in such form and as of such date as the Trustee may reasonably require of the names and addresses of Holders.

 Section 2.09 Transfer and Exchange. 
 (a) Provisions Applicable to All Transfers and Exchanges. 

  
 27 

 (i) Subject to the restrictions set forth in this Section 2.09, Definitive Notes and
beneficial interests in Global Notes may be transferred or exchanged from time to time as desired, and each such transfer or exchange will be noted by the Registrar in the Register. 

(ii) All Notes issued upon any registration of transfer or exchange in accordance with this Indenture will be the valid obligations of
the Company, evidencing the same debt, and entitled to the same benefits under this Indenture as the Notes surrendered upon such registration of transfer or exchange. 
 (iii) No service charge will be imposed on any Holder of a Definitive Note or any owner of a beneficial interest in a Global Note for any exchange or registration of transfer, but each of the Company, the
Trustee or the Registrar may require such Holder or owner of a beneficial interest to pay a sum sufficient to cover any transfer tax, assessment or other governmental charge imposed in connection with such registration of transfer or exchange.

 (iv) Unless the Company specifies otherwise, none of the Company, the Trustee, the Registrar or any co-registrar will be
required to exchange or register a transfer of any Note (i) surrendered for conversion, except to the extent that any portion of such Note has not been surrendered for conversion, (ii) subject to a Fundamental Change Repurchase Notice
validly delivered pursuant to Section 3.03 hereof, except to the extent any portion of such Note is not subject to a Fundamental Change Repurchase Notice, or (iii) after the Company has delivered a Redemption Notice pursuant to
Section 11.03 hereof, except to the extent that (A) the Company has failed to redeem such Note on the applicable Redemption Date in accordance with Article 11 hereof, (B) a portion of such Note was surrendered for conversion after the
applicable Redemption Date or (C) a portion of such Note was made subject to a Fundamental Change Repurchase Notice relating to a Fundamental Change Repurchase Date that will occur before the applicable Redemption Date. 

(v) The Trustee will have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on Transfer
imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Note (including any transfers between or among Depositary participants or beneficial owners of interests in any Global Note) other than to
require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of this Indenture, and to examine the same to determine substantial compliance as to
form with the express requirements hereof. 
 (b) In General; Transfer and Exchange of Beneficial Interests in Global Notes.
So long as the Notes are eligible for book-entry settlement with the Depositary, unless otherwise required by law, except to the extent required by Section 2.09(c) hereof: 

(i) all Notes will be represented by one or more Global Notes; 
 (ii) every transfer and exchange of a beneficial interest in a Global Note will be effected through the Depositary in accordance with the Applicable Procedures and the provisions of this Indenture
(including the restrictions on transfer set forth in Section 2.10 hereof); and 

  
 28 

 (iii) each Global Note may be transferred only as a whole and only (A) by the
Depositary to a nominee of the Depositary, (B) by a nominee of the Depositary to the Depositary or to another nominee of the Depositary or (C) by the Depositary or any such nominee to a successor Depositary or a nominee of such successor
Depositary. 
 (c) Transfer and Exchange of Global Notes. 

(i) Notwithstanding any other provision of this Indenture, each Global Note will be exchanged for Definitive Notes if the Depositary
delivers notice to the Company that: 
 (A) the Depositary is unwilling or unable to continue to act as Depositary; or

 (B) the Depositary is no longer registered as a clearing agency under the Exchange Act; and, 

in each case, the Company promptly delivers a copy of such notice to the Trustee and the Company fails to appoint a successor Depositary within 90 days
after receiving notice from the Depositary. 
 In each such case, (1) each Global Note will be deemed surrendered to the
Trustee for cancellation, (2) the Trustee will promptly cancel each such Global Note in accordance with the Applicable Procedures, (3) the Company, (x) in accordance with Section 2.05 hereof, will promptly execute, for each
beneficial interest in each Global Note so cancelled, an aggregate principal amount of Definitive Notes equal to the aggregate principal amount of such beneficial interest, registered in such name and authorized denominations as the Depositary
specifies, and bearing such legends as such Definitive Notes are required to bear under Sections 2.02 and Section 2.10 hereof, and, (y) as provided in Section 2.05(c) hereof, will promptly deliver to the Trustee such Definitive Notes
and a Company Order including the information specified in Section 2.05(c) hereof with respect to such Definitive Notes, and (4) the Trustee, upon receipt of such Definitive Notes and such Company Order, in accordance with
Section 2.05 hereof, will promptly authenticate, and deliver to the Holder specified in such Company Order, such Definitive Notes. 
 (ii) In addition: 
 (A) if an Event of Default has occurred and is continuing,
any owner of a beneficial interest in a Global Note may exchange such beneficial interest for Definitive Notes by delivering a written request to the Company, the Registrar and the Trustee; or 

(B) at any time, the Company may, in its sole discretion, at the request of the owner of a beneficial interest in a Global Note, permit
the exchange of such owner’s beneficial interest, by delivering a written request to the Registrar, the Trustee and the owner of such beneficial interest. 
 In each case, (1) upon receipt of such request, the Registrar will promptly deliver written notice of such request to the Company and the Trustee, which notice must identify the owner of the
beneficial interest to be exchanged, the aggregate principal amount of such beneficial interest 

  
 29 

 
and the CUSIP number of the relevant Global Note; (2) the Trustee, upon receipt of such notice, will promptly cause the aggregate principal amount of such Global Note to be reduced by the
aggregate principal amount of the beneficial interest to be so exchanged in accordance with the Applicable Procedures, (3) the Company (x) in accordance with Section 2.05 hereof, will promptly execute, for such beneficial interest, a
Definitive Note having aggregate principal amount equal to the aggregate principal amount of such beneficial interest, registered in the name of the owner specified in the notice delivered by the Registrar, and bearing such legends as such
Definitive Note is required to bear under Sections 2.02 and 2.10 hereof, and, (y) as provided in Section 2.05(c) hereof, will promptly deliver to the Trustee such Definitive Note and a Company Order including the information specified in
Section 2.05(c) hereof with respect to such Definitive Note, and (4) the Trustee, upon receipt of such Definitive Note and such Company Order, will promptly, in accordance with Section 2.05 hereof, authenticate, and deliver to the
Holder specified in such Company Order, such Definitive Note. If, after such exchange, all of the beneficial interests in a Global Note have been exchanged for Definitive Notes, such Global Note will be deemed surrendered to the Trustee for
cancellation, and the Trustee will cause such Global Note to be cancelled in accordance with the Applicable Procedures. 
 (d)
Transfer and Exchange of Definitive Notes. If Definitive Notes are issued, a Holder may: 
 (i) transfer a Definitive
Note by: (A) surrendering such Definitive Note for registration of transfer to the Registrar, together with any endorsements or instruments of transfer reasonably required by any of the Company, the Trustee and the Registrar; (B) if such
Definitive Note is a Restricted Note, delivering any documentation that any of the Company, the Trustee and the Registrar reasonably require to ensure that such transfer complies with Section 2.10 hereof and any applicable securities laws; and
(C) satisfying any other requirements for such transfer set forth in this Section 2.09 and Section 2.10 hereof. Upon the satisfaction of conditions (A), (B) and (C), (1) the Company, (x) in accordance with
Section 2.05 hereof, will promptly execute a new Definitive Note, in the name of the designated transferee, having an aggregate principal amount equal to that of the transferred Definitive Note and bearing such legends as such Definitive Note
is required to bear under Sections 2.02 and 2.10 hereof, and (y) as provided in Section 2.05(c) hereof, will promptly deliver to the Trustee such Definitive Note and a Company Order including the information specified in
Section 2.05(c) with respect to such Definitive Note, and (2) the Trustee, upon receipt of such Definitive Note and such Company Order, will promptly, in accordance with Section 2.05 hereof, authenticate, and deliver to the Holder
specified in such Company Order, such Definitive Note. 
 (ii) exchange one or more Definitive Notes for one or more other
Definitive Notes of any authorized denominations, and aggregate principal amount equal to the aggregate principal amount of the one or more Definitive Notes to be exchanged, by surrendering such one or more Definitive Notes, together with any
endorsements or instruments of transfer reasonably required by any of the Company, the Trustee and the Registrar, at any office or agency maintained by the Company for such purposes pursuant to Section 2.06 hereof. Whenever a Holder so
surrenders one or more Definitive Notes for exchange, (1) the Company, (x) in accordance with Section 2.05 hereof, will promptly execute one or more new Definitive Notes, each in the name of such Holder, in the authorized denomination
or denominations that such Holder requested (which authorized denomination or authorized denominations, as the case may 

  
 30 

 
be, must in aggregate, equal the aggregate principal amount of the one or more Definitive Notes to be exchanged), and bearing a unique registration number not contemporaneously outstanding and
such legends as such Definitive Note is required to bear under Sections 2.02 and 2.10 hereof, and (y) as provided in Section 2.05(c) hereof, will promptly deliver to the Trustee each such Definitive Note and a Company Order including the
information specified in Section 2.05(c) with respect to each such Definitive Note, and (2) the Trustee, upon receipt of each such Definitive Note and such Company Order, will promptly, in accordance with Section 2.05 hereof,
authenticate, and deliver to the Holder specified in such Company Order, each such Definitive Note. 
 (iii) transfer or
exchange a Definitive Note for a beneficial interest in a Global Note by (A) surrendering such Definitive Note for registration of transfer or exchange, together with any endorsements or instruments of transfer reasonably required by any of the
Company, the Trustee and the Registrar, at any office or agency maintained by the Company for such purposes pursuant to Section 2.06 hereof; (B) if such Definitive Note is a Restricted Note, delivering any documentation that any of the
Company, the Trustee and the Registrar reasonably require to ensure that such transfer complies with Section 2.10 hereof and any applicable securities laws; (C) satisfying any other requirements for such transfer set forth in this
Section 2.09 and Section 2.10 hereof; and (D) providing written instructions to the Trustee to make an adjustment in its books and records with respect to the applicable Global Note to reflect an increase in the aggregate principal
amount of the Notes represented by such Global Note, which instructions will contain information regarding the Depositary account to be credited with such increase. Upon the satisfaction of conditions (A), (B), (C) and (D), the Trustee
(1) will promptly cancel such Definitive Note and, (2) will promptly cause the aggregate principal amount of Notes represented by such Global Note to be increased by the aggregate principal amount of such Definitive Note, and credit, or
cause to be credited, the account of the Person specified in the instructions provided by the exchanging Holder in an amount equal to the aggregate principal amount of such Definitive Note, in each case, in accordance with the Applicable Procedures.
If at the time of such exchange, no Global Notes are then outstanding, the Company, (x) in accordance with Section 2.05 hereof, will promptly execute and deliver to the Trustee, a new Global Note registered in the name of the Depositary or
a nominee of the Depositary, as the case may be, having the appropriate aggregate principal amount, and bearing such legends as such Global Note is required to bear under Sections 2.02 and 2.10 hereof, and (y) as provided in
Section 2.05(c) hereof, will promptly deliver to the Trustee such Global Note and a Company Order including the information specified in Section 2.05(c) with respect to such Global Note, and (2) the Trustee, upon receipt of such
Global Note and such Company Order, will promptly, in accordance with Section 2.05 hereof, authenticate, and deliver to the Depositary, its nominee, or a custodian of the Depositary or its nominee, as the case may be, such Global Note.

 Section 2.10 Transfer Restrictions. 
 (a) Transfers Prior to the Resale Termination Date. Prior to the Resale Restriction Termination Date and at any time the Company reasonably determines that the legend is required to comply with
applicable law, the Notes will bear the Restricted Notes Legend and will be subject to the restrictions set forth therein and will be deemed to be assigned the Restricted Notes CUSIP. Prior to the Resale Restriction Termination Date and at any time
the Company reasonably determines that the legend is required to comply with applicable law, the shares of 

  
 31 

 
Common Stock issuable upon conversion of the Notes will be issued solely in certificated form and will bear the Restricted Stock Legend and the Restricted Stock CUSIP and be subject to the
restrictions set forth therein. 
 (b) Resale Restriction Termination Date. 

(i) No later than the 15th day immediately following the Free Trade Date, or the next succeeding Business Day if such day is not a Business Day,
the Company will provide the Free Transferability Certificate to the Trustee and the Registrar. The date on which the Company provides such Free Transferability Certificate to the Trustee and the Registrar is referred to as the “Resale
Restriction Termination Date.” 
 (ii) Upon receipt of the Free Transferability Certificate by the Trustee and the
Registrar: 
 (A) the Restricted Notes Legend will be deemed removed from any Notes bearing such legend and the Restricted
Notes CUSIP will be deemed removed from the Notes and replaced with the Unrestricted Notes CUSIP; 
 (B) the Restricted Stock
Legend will be deemed removed from any shares of Common Stock previously issued upon conversion of the Notes and the Restricted Stock CUSIP will be deemed removed from the shares of Common Stock and replaced with the Unrestricted Stock CUSIP; and

 (C) thereafter, shares of Common Stock issued upon conversion of the Notes will be assigned the Unrestricted Stock CUSIP for
shares of Common Stock that do not constitute “restricted securities” (as defined in Rule 144 under the Securities Act) and will not bear the Restricted Stock Legend (except as provided in Section 2.10(a)) or any similar legend.

 (iii) The Company and the Trustee will comply with the Applicable Procedures and otherwise use reasonable efforts to cause
the Notes to be identified by the Unrestricted Notes CUSIP in the facilities of the Depositary by the date the Free Transferability Certificate is delivered to the Trustee or as promptly as possible thereafter. Without limiting the foregoing, if
applicable, the Company will provide DTC with the instruction letter for DTC’s mandatory exchange process in accordance with the Applicable Procedures prior to the date of the delivery of the Free Transferability Certificate to the Trustee. In
addition, the Company (or the Trustee upon instruction by the Company) will notify Bloomberg simultaneously with providing the Free Transferability Certificate to the Trustee and the Registrar, will provide Bloomberg with a copy of such Free
Transferability Certificate and will use reasonable efforts to cause Bloomberg to adjust its screen page for the Notes to indicate that they are thereafter unrestricted and replace the Restricted Notes CUSIP with the Unrestricted Notes CUSIP
thereon. 
 (iv) Notwithstanding subsections (i) and (ii) of this Section 2.10(b), the Company will not be
required to deliver the Free Transferability Certificate (or may indicate exceptions in the Free Transferability Certificate applicable to specifically identified Notes or shares of Common Stock) if it reasonably believes that removal of the
Restricted Notes Legend or Restricted Stock Legend or the changes to the CUSIP numbers for the Notes or the Common Stock issuable upon conversion of the Notes could result in or facilitate transfers of the Notes or

  
 32 

 
the Common Stock issuable upon conversion of the Notes in violation of applicable law. This Section 2.10(b)(iv) does not limit the application of Section 4.04. 

Section 2.11 Replacement Notes. 
 If (a)(i) a mutilated Note is surrendered to the Registrar or (ii) the Holder of a Note claims that such Note has been lost, destroyed or stolen and provides the Company and the Trustee with
(A) evidence of such loss, theft or destruction that is reasonably satisfactory to the Company and the Trustee and (B) any amount or kind of security or indemnity that either of the Company or the Trustee reasonably request to protect
itself from any loss that it may suffer upon replacement of such Note, and, in either case, (b) such Holder satisfies any other reasonable requirements of the Trustee, including the payment of any tax or other governmental charge that may be
imposed in connection with the replacement of such Note, then, in either case, unless the Company or the Trustee receives written notice that such Note has been acquired by a bona fide purchaser, the Company will, in accordance with
Section 2.05 hereof, promptly execute and deliver to the Trustee, and the Trustee, upon receipt of a Company Order, in accordance with Section 2.05 hereof, will promptly authenticate and deliver, in the name of such Holder, a replacement
Note having the same aggregate principal amount as the Note that was mutilated or claimed to be lost, destroyed or stolen, bearing any restrictive legends required by Section 2.10 hereof and with a certificate number not contemporaneously
outstanding. 
 Every new Note issued pursuant to this Section 2.11 in exchange for any mutilated Note, or in lieu of any
destroyed, lost or stolen Note, will constitute an original contractual obligation of the Company and any other obligor upon the Notes, regardless of whether the mutilated, destroyed, lost or stolen Note will be at any time enforceable by anyone,
and will be entitled to all benefits of (and will be subject to all the limitations set forth in) this Indenture equally and proportionately with any and all other Notes duly issued hereunder. 

Section 2.12 Temporary Notes. 
 Until Definitive Notes are ready for delivery, the Company may execute and the Trustee or an authenticating agent appointed by the Trustee will, upon written request of the Company, authenticate and
deliver temporary Notes (printed or lithographed) (“Temporary Notes”). Temporary Notes will be issuable in any authorized denomination, and substantially in the form of Definitive Notes, but with such omissions, insertions and
variations as may be appropriate for Temporary Notes, all as may be determined by the Company. Every such Temporary Note will be executed by the Company and authenticated by the Trustee or such authenticating agent upon the same conditions and in
substantially the same manner, and with the same effect, as the Definitive Notes. Without unreasonable delay the Company will prepare, execute and deliver to the Trustee or such authenticating agent Definitive Notes (other than any Global Note) and
thereupon any or all Temporary Notes (other than any Global Note) may be surrendered in exchange therefor, at each office or agency maintained by the Company pursuant to Section 2.06 hereof and the Trustee or such authenticating agent will
authenticate and deliver in exchange for such Temporary Notes Definitive Notes having an aggregate principal amount equal to such Temporary Notes. Such exchange will be made by the Company at its own expense and without any charge therefor. Until so
exchanged, the Temporary Notes will, in all 

  
 33 

 
respects, be entitled to the same benefits and subject to the same limitations under this Indenture as Definitive Notes authenticated and delivered hereunder. 

Section 2.13 Cancellation. 
 At any time, the Company may deliver Notes to the Trustee for cancellation. Whenever any Note is surrendered to the Registrar, Conversion Agent or Paying Agent for registration of transfer, exchange,
conversion, repurchase, redemption or payment, the Registrar, Conversion Agent or Paying Agent, as the case may be, will promptly forward such Note to the Trustee. Upon receipt of any such Note, the Trustee, in its customary manner, will promptly
cancel and dispose of such Note. The Company may not issue new Notes to replace Notes that it has repurchased, redeemed, paid or delivered to the Trustee for cancellation or that a Holder has converted pursuant to Article 10 hereof. 

Section 2.14 Outstanding Notes. 
 At any time, Notes outstanding are limited to all Notes authenticated by the Trustee except (i) those cancelled by it, (ii) those delivered to it for cancellation and (iii) those deemed not
outstanding under Sections 3.05, 10.02 and 11.06 hereof and clauses (a) and (b) of this Section 2.14. 
 (a) If a
Note is replaced pursuant to Section 2.11 hereof, such Note will cease to be outstanding at the time of its replacement unless the Trustee and the Company receive proof satisfactory to them that such Note is held by a bona fide purchaser.

 (b) In addition, if the Company, any other obligor or an Affiliate of the Company or an Affiliate of such other obligor holds
a Note, such Note will be disregarded and deemed not to be outstanding for purposes of determining whether the Holders of the requisite aggregate principal amount of Notes have given or concurred in any request, demand, authorization, direction,
notice, consent, waiver or other action hereunder. Subject to the foregoing, only Notes outstanding at the time of any such determination will be considered in such determination (including determinations pursuant to Articles 6 and 9 hereof).

 Section 2.15 Persons Deemed Owners. 
 Prior to due presentment of a Note for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name such Note is registered in the
Register as the owner of such Note for the purpose of receiving the payment of the principal, the Fundamental Change Repurchase Price or Redemption Price of, and interest, if any, on, such Note, for the purpose of conversion of such Note and for all
other purposes whatsoever with respect to such Note, and none of the Company, the Trustee or any agent of the Company or the Trustee will be affected by any notice to the contrary. 

Section 2.16 Repurchases. 
 The Company may, from time to time, repurchase Notes in open market purchases or in negotiated transactions without delivering prior notice to Holders. Any Notes that are

  
 34 

 
repurchased or owned by the Company will be submitted to the Trustee for cancellation and will be duly retired by the Company. 

Section 2.17 CUSIP and ISIN Numbers. 
 (a) The Company in issuing the Notes may use “CUSIP” or “ISIN” numbers (if then generally in use), and, if so, the Trustee shall use CUSIP or ISIN numbers in notices of redemption as a
convenience to Holders; provided that any such notice may state that no representation is made as to the correctness of such numbers either as printed on the Notes or as contained in any notice of a redemption and that reliance may be placed
only on the other identification numbers printed on the Notes, and any such redemption shall not be affected by any defect in or omission of such numbers. The Company will promptly notify the Trustee in writing of any change in the CUSIP or ISIN
numbers. 
 (b) In addition, if, when any shares of Common Stock are issued upon conversion of a Note, CUSIP and ISIN numbers
are generally in use, the Company will use CUSIP and ISIN numbers with respect to such shares of Common Stock, which CUSIP and ISIN numbers (i) for shares of Common Stock to which the restrictions on Transfer set forth in the Restricted Stock
Legend apply, will be the Restricted Stock CUSIP and the corresponding ISIN, and (ii) for shares of Common Stock to which the restrictions on Transfer set forth in the Restricted Stock Legend do not apply, will be the Unrestricted Stock CUSIP
and the corresponding ISIN. 
 (c) Whenever any of the CUSIP numbers with respect to the Notes or the shares of Common Stock
issuable upon conversion of the Notes changes, ceases to be used, or begins to be used, the Company will deliver prompt written notice of such change, cessation, or beginning to each of the Trustee and the Holders. 

ARTICLE 3 

REPURCHASE AT THE OPTION OF THE HOLDER 
 Section 3.01 Fundamental Change Permits Holders To Require The Company To Repurchase the Notes. 
 (a) General. If a Fundamental Change occurs at any time prior to the Maturity Date, each Holder will have the right to require the Company to repurchase for cash all, or any portion, of its Notes
in principal amount equal to $1,000 or an integral multiple of $1,000 in excess thereof on the Fundamental Change Repurchase Date for such Fundamental Change for an amount of cash equal to the corresponding Fundamental Change Repurchase Price.

 (b) Fundamental Change Repurchase Price. The “Fundamental Change Repurchase Price” means, for any
Notes to be repurchased on any Fundamental Change Repurchase Date, a price equal to 100% of the principal amount of such Notes, plus accrued and unpaid interest, if any, on such Notes to, but excluding, such Fundamental Change Repurchase Date;
provided, however, that if a Fundamental Change Repurchase Date occurs after a Regular Record Date, but on or prior to the corresponding Interest Payment Date, the Company will pay the accrued and unpaid interest on such Notes on such
Interest Payment Date to the Holder of such Notes on as of the Close of Business on such Regular Record Date. 

  
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 (c) Fundamental Change Repurchase Date. The “Fundamental Change Repurchase
Date” means, for any Fundamental Change, the date specified by the Company in the Fundamental Change Notice for such Fundamental Change, which date will be not less than 20 Business Days, nor more than 35 Business Days, immediately
following the Fundamental Change Notice Date for such Fundamental Change. 
 Section 3.02 Fundamental Change Notice.

 (a) General. On or before the 10th calendar day immediately following the effective date of a Fundamental Change, the
Company will deliver, or cause to be delivered, to each Holder (and to any beneficial owners of a Global Note, as required by applicable law), the Trustee and the Paying Agent written notice of the occurrence of such Fundamental Change and the
resulting fundamental change repurchase right (the “Fundamental Change Notice,” and the date of such mailing or delivery, the “Fundamental Change Notice Date”). Simultaneously with sending any Fundamental Change
Notice to the Holders, the Trustee and the Paying Agent, the Company will publish a notice containing the same information as the Fundamental Change Notice on its website or through such other public medium as the Company may use at such time.

 For any Fundamental Change, the Fundamental Change Notice corresponding to such Fundamental Change will specify: 

(A) the events causing such Fundamental Change; 
 (B) the effective date of such Fundamental Change; 
 (C) the last date on which a
Holder may exercise its right to require the Company to repurchase its Notes as a result of such Fundamental Change under this Article 3, which will be the third business day immediately preceding the Fundamental Change Repurchase Date; 

(D) the procedures that a Holder must follow to require the Company to repurchase a Note; 

(E) the Fundamental Change Repurchase Price for each $1,000 principal amount of Notes for such Fundamental Change; 

(F) the Fundamental Change Repurchase Date for such Fundamental Change; 

(G) the name and address of the Paying Agent and the Conversion Agent, if applicable; 

(H) the Conversion Rate in effect on the Fundamental Change Notice Date for such Fundamental Change and the Last Reported Sale Price of
the Common Stock on the Trading Day immediately preceding the Fundamental Change Notice Date; 

  
 36 

 (I) if applicable, any adjustments that will be made to the Conversion Rate as a result of
such Fundamental Change, including any Additional Shares by which the Conversion Rate will be increased pursuant to Section 10.07 hereof for a Holder that converts a Note “in connection with” such Fundamental Change; 

(J) that any Notes with respect to which a Fundamental Change Repurchase Notice has been delivered by a Holder may be converted only if
such Holder withdraws such Fundamental Change Repurchase Notice in accordance with the terms of this Indenture; 
 (K) the
procedures for withdrawing a Fundamental Change Repurchase Notice; 
 (L) that if a Note or portion of a Note is subject to a
validly delivered Fundamental Change Repurchase Notice, unless the Company defaults in paying the Fundamental Change Repurchase Price for such Note or portion of a Note, interest, if any, on such Note or portion of a Note will cease to accrue on and
after the Fundamental Change Repurchase Date; and 
 (M) the CUSIP and ISIN number(s) of the Notes. 

(b) Failure or Defect. Notwithstanding anything provided elsewhere in this Indenture, neither the failure of the Company to
deliver a Fundamental Change Notice nor a defect in a Fundamental Change Notice delivered by the Company will limit the repurchase rights of any Holder under this Article 3 or impair or otherwise affect the validity of any proceedings relating to
the repurchase of any Note pursuant to this Article 3. 
 Section 3.03 Fundamental Change Repurchase Notice.

 (a) General. To exercise its repurchase rights under Section 3.01(a) hereof with respect to any Fundamental
Change, a Holder must deliver to the Paying Agent, on or before the Close of Business on the third Business Day immediately preceding the Fundamental Change Repurchase Date, subject to extension to comply with applicable law: 

(A) a duly completed “Form of Fundamental Change Repurchase Notice” in the form of Attachment 2 of the Notes that such
Holder is tendering for repurchase (a “Fundamental Change Repurchase Notice”); and 
 (B) the Notes that such
Holder is tendering for repurchase, (A) by book-entry transfer if such Notes are Global Notes, or (B) by physical delivery, if such Notes are Definitive Notes, in each case, together with any endorsements or other documents reasonably
requested by the Paying Agent, the Trustee or the Company. 
 (b) Contents of Fundamental Change Repurchase Notice. The
Fundamental Change Repurchase Notice for any Note must state: 

  
 37 

 (i) if such Note is to be repurchased in part, the principal amount of such Note to be
repurchased, which principal amount must equal $1,000 or an integral multiple of $1,000 in excess thereof; 
 (ii) that such
Note will be repurchased by the Company pursuant to the provisions of this Article 3 hereof; and 
 (iii) if such Note is a
Definitive Note, the certificate number of such Note. 
 If the Notes to be repurchased are Global Notes, the Fundamental Change
Repurchase Notice for such Notes must comply with the Applicable Procedures. 
 (c) Notice to Company. If any Holder
validly delivers to the Paying Agent a Fundamental Change Repurchase Notice with respect to a Note or any portion of a Note, the Paying Agent will promptly deliver to the Company a copy of such Fundamental Change Repurchase Notice. 

(d) Effect of Improper Notice. Unless and until the Paying Agent receives a validly endorsed and delivered Fundamental Change
Repurchase Notice with respect to a Note, together with such Note, in a form that conforms in all material aspects with the description contained in such Fundamental Change Repurchase Notice, the Holder submitting the Notes will not be entitled to
receive the Fundamental Change Repurchase Price for such Note. 
 Section 3.04 Withdrawal of Fundamental Change
Repurchase Notice. 
 (a) General. After a Holder delivers a Fundamental Change Repurchase Notice with respect to a
Note, such Holder may withdraw such Fundamental Change Repurchase Notice with respect to such Note or any portion of such Note in principal amount equal to $1,000 or an integral multiple of $1,000 in excess thereof by delivering to the Paying Agent
a written notice of withdrawal prior to the Close of Business on the third Business Day immediately preceding the Fundamental Change Repurchase Date to the Paying Agent. Any such withdrawal notice must state: 

(i) the principal amount of the Notes with respect to which such notice of withdrawal pertains, which must equal $1,000 or an integral
multiple of $1,000 in excess thereof; 
 (ii) the principal amount of the Notes that remains subject to the original Fundamental
Change Repurchase Notice, which portion must have a principal amount equal to $1,000 or an integral multiple of $1,000 in excess thereof; and 
 (iii) if the Notes subject to such Fundamental Change Repurchase Notice were Definitive Notes, the certificate numbers of the Notes to be withdrawn and the certificate numbers of the Notes that will
remain subject to the Fundamental Change Repurchase Notice. 
 If the Notes to be withdrawn are Global Notes, a Holder must
deliver its notice of withdrawal in compliance with the Applicable Procedures. 

  
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 (b) Return of Note. Upon receipt of a validly delivered withdrawal notice, the Paying
Agent will promptly (i) if such notice pertains to a Definitive Note or a portion of a Definitive Note, return such Note or portion of a Note to such Holder, in the amount specified in such withdrawal notice; and, (ii) if such notice
pertains to a beneficial interest in a Global Note, in compliance with the Applicable Procedures, deem to be cancelled any instructions for book-entry transfer of such beneficial interest, in the amount specified in such withdrawal notice.

 (c) Notice to Company. If any Holder validly delivers to the Paying Agent a notice of withdrawal with respect to a
Note or any portion of a Note, the Paying Agent will promptly deliver to the Company a copy of such notice of withdrawal. 

Section 3.05 Effect of Fundamental Change Repurchase Notice. 

(a) General. If a Holder validly delivers to the Paying Agent a Fundamental Change Repurchase Notice (together with all necessary
endorsements) with respect to a Note, such Holder may no longer convert such Note unless and until such Holder validly withdraws such Fundamental Change Repurchase Notice in accordance with Section 3.04 hereof. 

(b) Timing of Payment. Upon the Paying Agent’s receipt of (i) a valid Fundamental Change Repurchase Notice (together
with all necessary endorsements) and (ii) the Notes to which such Fundamental Change Repurchase Notice pertains, the Holder of the Notes to which such Fundamental Change Repurchase Notice pertains will be entitled, except to the extent such
Holder has validly withdrawn such Fundamental Change Repurchase Notice in accordance with Section 3.04 hereof, to receive the Fundamental Change Repurchase Price with respect to such Notes on the later of (i) the Fundamental Change
Repurchase Date and (ii)(A) if such Notes are Definitive Notes, the date of delivery of such Notes to the Paying Agent, or (B) if such Notes are Global Notes, the date of book-entry transfer of such Notes to the Paying Agent, or, if such
later date is not a Business Day, the Business Day immediately following such later date. 
 (c) Effect of Deposit. If,
as of 11:00 a.m., New York City time, on the Fundamental Change Repurchase Date for any Fundamental Change, the Company, in accordance with Section 3.08 hereof, has deposited with the Paying Agent money sufficient to pay the Fundamental Change
Repurchase Price for all Notes subject to a Fundamental Change Repurchase Notice validly delivered in accordance with Section 3.03 hereof and not validly withdrawn in accordance with Section 3.04 hereof, at the Close of Business on the
Fundamental Change Repurchase Date: 
  

	 	(1)	the Notes to be repurchased will cease to be outstanding and interest will cease to accrue on such Notes (whether or not book-entry transfer of such Notes is made or
whether or not such Notes are delivered to the Paying Agent); and 

  

	 	(2)	all other rights of the Holders of such Notes with respect to such Notes (other than the right to receive payment of the Fundamental Change Repurchase Price upon
delivery or transfer of such Notes and any Defaulted Amounts with respect to the Notes) will terminate. 

  
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 Section 3.06 Notes Repurchased in Part. 

If any Definitive Note is to be repurchased only in part, the Holder must surrender such Note at the office of the Paying Agent (with, if
the Company or the Trustee so requires, due endorsement by, or a written instrument of transfer in form satisfactory to the Company and the Trustee duly executed by, the Holder of such Note or such Holder’s attorney-in-fact, duly authorized in
writing), whereupon the Company, in accordance with Section 2.05 hereof, will promptly execute, and, upon receipt of a Company Order, the Trustee, in accordance with Section 2.05 hereof, will promptly authenticate and deliver, to the
surrendering Holder, a new Note or Notes of any authorized denomination or denominations requested by such Holder in aggregate principal amount equal to the portion of the principal amount of the Note so surrendered which is not repurchased. If any
Global Note is repurchased in part, the Company will instruct the Trustee to decrease the principal amount of such Global Note by the principal amount repurchased. Any Notes that are repurchased or owned by the Company, whether or not in
connection with a Fundamental Change, will be submitted to the Trustee for cancellation and will be duly retired by the Company. 
 Section 3.07 Covenant to Comply with Securities Laws upon Repurchase of Notes. 
 In connection with any repurchase offer pursuant to a Fundamental Change Repurchase Notice under this Article 3, the Company will, to the extent applicable, (i) comply with Rule 13e-4 and any other
tender offer rules under the Exchange Act that may be applicable at the time of the offer to repurchase the Notes, (ii) file the related Schedule TO (or any successor schedule, form or report) under the Exchange Act, and (iii) otherwise
comply with any applicable United States federal and state securities laws so as to permit Holders to exercise their rights and obligations under Section 3.01 hereof in the time and in the manner specified in Sections 3.01 and 3.03 hereof.

 Section 3.08 Deposit of Fundamental Change Repurchase Price. 

Prior to 11:00 a.m., New York City time, on the Fundamental Change Repurchase Date, the Company will deposit with the Trustee or with the
Paying Agent (or, if the Company or a Subsidiary or an Affiliate of either of them is acting as the Paying Agent, will segregate and hold in trust as provided in Section 2.07 hereof) an amount of immediately available funds sufficient to pay
the Fundamental Change Repurchase Price of all the Notes or portions thereof that the Company is required to repurchase on such Fundamental Change Repurchase Date. 
 Section 3.09 Covenant Not to Repurchase Notes upon Certain Events of Default. 
 (a) General. Notwithstanding anything to the contrary in this Article 3, the Company will not purchase any Notes under this Article 3 if, as of the Fundamental Change Repurchase Date, the principal
amount of the Notes has been accelerated, such acceleration has not been rescinded and such acceleration did not result from a Default that would be cured by the Company’s payment of the Fundamental Change Repurchase Price. 

(b) Deemed Withdrawals. If, on any Fundamental Change Repurchase Date, (i) a Fundamental Change Repurchase Notice for a Note
has been validly tendered in accordance with Section 3.03 hereof and has not been validly withdrawn in accordance with Section 3.04 hereof, 

  
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and (ii) pursuant to Section 3.09(a), the Company is not permitted to purchase Notes, the Paying Agent, upon receipt of written notice from the Company stating that the Company,
pursuant to Section 3.09(a), is not permitted to purchase Notes, will deem such Fundamental Change Repurchase Notice withdrawn. 
 (c) Return of Notes. If a Holder tenders a Note for purchase pursuant to this Article 3 and, on the Fundamental Change Repurchase Date, pursuant to Section 3.09(a), the Company is not
permitted to purchase such Note, the Paying Agent will (i) if such Note is a Definitive Note, return such Note to such Holder, and (ii) if such Note is held in book-entry form, in compliance with the Applicable Procedures, deem to be
cancelled any instructions for book-entry transfer of such Note. 
 ARTICLE 4 

COVENANTS 

Section 4.01 Payment of Notes. 
 The Company will pay or cause to be paid the principal of, the Fundamental Change Repurchase Price or Redemption Price for, and any accrued and unpaid interest on, the Notes on the dates and in the manner
required under this Indenture. Any principal of, the Fundamental Change Repurchase Price or Redemption Price for, or interest on, a Note will be considered paid on the date due if the Paying Agent, if other than the Company or a Subsidiary thereof,
holds, as of 11:00 a.m. New York City time on the due date, money deposited by the Company in immediately available funds and designated for, and sufficient to pay, such principal, Fundamental Change Repurchase Price, Redemption Price, or interest
then due. 
 Section 4.02 144A Information. 

Whenever the Company is not subject to Section 13 or Section 15(d) of the Exchange Act, if any Notes or shares of Common Stock
issuable upon the conversion of the Notes constitute “restricted securities” within the meaning of Rule 144, the Company will, upon the request of any Holder or beneficial owner of the Notes, or a holder or beneficial owner of the Common
Stock issuable upon the conversion of the Notes, promptly furnish or cause to be furnished to the applicable Holder, beneficial owner, or any prospective purchaser designated by the applicable Holder or beneficial owner, of the Notes, or any holder,
beneficial owner, or any prospective purchased designated by the applicable holder or beneficial owner, of the Common Stock, as the case may be, all of the information that a prospective purchaser of the Notes or the Common Stock, as the case may
be, is required to receive under Rule 144A(d)(4) of the Securities Act for such Notes or shares of Common Stock, as the case may be, to be resold to such prospective purchaser pursuant the exemption from registration provided by Rule 144A.

 Section 4.03 Reports. 
 The Company will deliver to the Trustee copies of its annual reports and of the information, documents and other reports (or copies of such portions of any of the foregoing as the SEC may by rules and
regulations prescribe, but excluding any information, documents or reports, or portions thereof subject to confidential treatment and correspondence with the SEC) 

  
 41 

 
that the Company is required to deliver to the SEC under Sections 13 or 15(d) of the Exchange Act within 15 days after the Company is required to file such information, documents or other reports
with the SEC (after giving effect to any grace period provided by Rule 12b-25 under the Exchange Act). Any document filed by the Company with the SEC via the EDGAR system (or any successor thereto) will be deemed to be delivered to the Trustee at
the time such document is filed via the EDGAR system (or any successor thereto); provided, however, that the Trustee will have no responsibility whatsoever to determine whether the Company has made any filing via the EDGAR system (or
any successor thereto). 
 Delivery of such annual reports, and such other documents, information and other reports to the
Trustee will be for informational purposes only, and the Trustee’s receipt of such will not constitute constructive notice of any information contained therein or determinable from information contained therein, including the Company’s
compliance with any of its covenants hereunder (as to which the Trustee is entitled to rely conclusively on Officer’s Certificates). 
 Section 4.04 Additional Interest. 
 (a)
General. If, at any time during the period beginning on, and including, the date that is six months after the Issue Date and ending on, but not including, the Free Trade Date, the Company fails to timely file (after giving effect to any grace
period provided by Rule 12b-25) any document or report that it is required to file with the SEC pursuant to Sections 13 or 15(d) of the Exchange Act, as applicable (other than current reports on Form 8-K) or the Notes are not otherwise Freely
Tradable, including pursuant to Rule 144 by Holders other than affiliates (as defined in Rule 144) or Holders that were affiliates (as defined in Rule 144) during the three months preceding the date of the proposed transfer, the Company will pay
additional interest (the “Additional Interest”) on the principal amount of then outstanding Notes. The Additional Interest will accrue from the due date of each such missed filing or the date that the Notes otherwise cease to be
Freely Tradable, until the date that the Notes become Freely Tradable. Such Additional Interest will initially accrue at the rate of 0.25% per annum on the principal amount of then outstanding Notes. If such Additional Interest accrues for more
than 90 consecutive days, the rate at which the Additional Interest accrues will increase to 0.50% per annum on the principal amount of then outstanding Notes beginning on the 91st consecutive day on which it accrues and ending on the last consecutive day on which it continues to accrue;
provided that such Additional Interest shall cease to accrue on the Free Trade Date. 
 In addition,
if and for so long as, the Notes are not Freely Tradable at all times on and after the Free Trade Date, or the Restrictive Notes Legend has not been deemed to be removed and the Notes are deemed to be assigned the Restricted Notes CUSIP after the
15th day immediately following the Free Trade Date, or the
next succeeding Business Day if such day is not a Business Day, the Company will pay Additional Interest on the Notes at a rate of 0.50% per annum. Such Additional Interest will accrue on each day during such period on which the Notes are not
Freely Tradable and the Restrictive Notes Legend is deemed removed and the Notes are deemed to be assigned the Unrestricted Notes CUSIP. In each case, the Additional Interest will be payable on the same dates and in the same manner as the stated
interest on the Notes. 
 Notwithstanding the foregoing, the Company will not be required to pay Additional Interest with
respect to any failure to timely file any report, if the Notes are not eligible for resale 

  
 42 

 
under Rule 144 or if the Notes are not Freely tradable, in each case as required under this Section 4.04: on any date on which (i) the Company has filed a shelf registration statement
for the resale of the Notes and any shares of Common Stock issuable upon conversion of the Notes, (ii) such shelf registration statement is effective and usable by Holders identified therein as selling security holders for the resale of the
Notes and any shares of Common Stock issued upon conversion of the Notes, (iii) the Holders may register the resale of their Notes under such shelf registration statement on terms customary for the resale of convertible securities offered in
reliance on Rule 144A and (iv) the Notes and/or shares of Common Stock sold pursuant to such shelf registration statement become Freely Tradable as a result of such sale. 
 (b) Notice to Trustee. If the Company is required to pay Additional Interest on any Note, no later than three Business Days prior to the date on which such Additional Interest is scheduled to be
paid, the Company will provide to the Trustee (and if the Trustee is not the Paying Agent, to the Paying Agent) an Officer’s Certificate, which Officer’s Certificate will state (i) that the Company is obligated to pay Additional
Interest pursuant to this Section 4.04, (ii) the amount of such Additional Interest that the Company is required to pay under this Section 4.04, (iii) the amount of such Additional Interest that the Company will pay,
(iv) the scheduled date on which such Additional Interest will be paid to Holders and (v) a direction that the Trustee (or, if the Trustee is not the Paying Agent, the Paying Agent) pay such Additional Interest to the extent it receives
funds from the Company to do so, on the scheduled payment date for such Additional Interest. The Trustee will not have any duty or responsibility to any Holder to determine whether any Additional Interest is payable, or, if any Additional Interest
is payable, the amount of such Additional Interest that is payable. 
 Section 4.05 Compliance Certificate.

 (a) Annual Compliance Certificate. Within 120 days after the end of each fiscal year of the Company, beginning with
the fiscal year ending on December 31, 2012, the Company will deliver to the Trustee an Officer’s Certificate, which Officer’s Certificate will state to the knowledge of the Officer signing such Officer’s Certificate,
(i) whether the Company has kept, observed, performed and fulfilled each and every covenant contained in this Indenture and is not in Default in the performance or observance of any of the terms, provisions and conditions of this Indenture or,
if one or more Defaults or Events of Default have occurred, what events triggered such Defaults or Events of Default and what actions the Company is taking or proposes to take with respect to such Defaults or Events of Default. 

(b) Certificate of Default or Event of Default. Within 30 days after becoming aware of the occurrence of any Default, the Company
will deliver to the Trustee an Officer’s Certificate describing such Default, its status and a description, in reasonable detail, of what action the Company is taking or proposes to take with respect to such Default. 

Section 4.06 Restriction on Purchases by the Company and by Affiliates of the Company. 

The Company will use commercially reasonable efforts to prevent any affiliate of the Company (as defined in Rule 144) or person that is
not an affiliate (as defined in Rule 144) of 

  
 43 

 
the Company but has been an affiliate (as defined in Rule 144) of the Company within the three immediately preceding months from acquiring any Note or any beneficial interest therein. 

Section 4.07 [Reserved]. 
 Section 4.08 Corporate Existence. 
 Subject to Article 5 hereof, the
Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate existence. 

Section 4.09 Par Value Limitation. 
 The Company will not take any action that, after giving effect to any adjustment pursuant to Section 10.05 or 10.07, would result in the Conversion Price becoming less than the par value of one share
of Common Stock. In addition, the Company will not adjust the Conversion Rate pursuant to Section 10.06 such that the Conversion Price would be less than the par value of one share of Common Stock. 

Section 4.10 Stay, Extension and Usury Laws. 
 The Company covenants that, to the extent that it may lawfully do so, it will not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension
or usury law wherever enacted, now or at any time hereafter in force, that may affect the covenants or the performance of this Indenture; and the Company, to the extent that it may lawfully do so, hereby expressly waives all benefit or advantage of
any such law, and covenants that it will not, by resort to any such law, hinder, delay or impede the execution of any power herein granted to the Trustee, but will instead suffer and permit the execution of every such power as though no such law has
been enacted. 
 Section 4.11 Further Instruments and Acts. 

Upon request of the Trustee, the Company will execute and deliver such further instruments and do such further acts as may be reasonably
necessary or proper to carry out more effectively the terms of this Indenture. 
 Section 4.12 Limitation on Incurrence
of Additional Indebtedness. 
 For so long as any Notes are outstanding, the Company will not, nor will it permit any of the
Subsidiaries to, directly or indirectly, incur any Indebtedness other than Permitted Debt; provided, however, that the Company may, and may permit any of the Subsidiaries to, incur Indebtedness if: 

(a) no Default or Event of Default shall have occurred and be continuing at the time of such incurrence or would occur as a consequence
of such incurrence; 

  
 44 

 (b) after giving pro forma effect to such incurrence, the Consolidated Leverage Ratio would
not exceed 2.75 to 1.00; and 
 (c) after giving pro forma effect to such incurrence, the Consolidated Fixed Charge Coverage
Ratio would not be less than 1.25 to 1.00. 
 For purposes of determining Consolidated Fixed Charge Coverage Ratio, pro forma
effect will be given to the incurrence of any Indebtedness giving rise to the need to determine Consolidated Leverage Ratio and Consolidated Fixed Charge Coverage Ratio as if such Indebtedness was incurred at the beginning of the applicable period.
Furthermore, in giving such pro forma effect, interest on any such Indebtedness determined on a fluctuating basis will be deemed to have accrued at a fixed rate per annum equal to the interest rate on the date of determination of Consolidated Fixed
Charge Coverage Ratio (after giving effect to any interest rate Swap Contracts applicable to such Indebtedness and any interest rate elections made by the Company or the Subsidiaries). 

ARTICLE 5 

CONSOLIDATION, MERGER AND SALE OF ASSETS 
 Section 5.01 Company May Consolidate, Merge or Sell Its Assets Only on Certain Terms. 
 The Company will not, directly or indirectly, (1) consolidate with or merge with or into any other Person, or (2) sell, convey, transfer or lease all or substantially all of its consolidated
properties and assets to any other Person (any such transaction, a “Reorganization Event”), unless: 
 (a)
either: 
 (i) the Company is the surviving corporation; or 

(ii) the resulting, surviving or transferee Person (if other than the Company) of such Reorganization Event (the “Reorganization
Successor Corporation”): 
 (A) is a corporation organized and validly existing under the laws of the United States of
America, any State thereof or the District of Columbia; and 
 (B) expressly assumes, by executing and delivering a
supplemental indenture to the Trustee that is reasonably satisfactory in form to the Trustee in accordance with Section 9.03 hereof, all of the obligations of the Company under the Notes and this Indenture; and 

(b) immediately after giving effect to such Reorganization Event, no Default will have occurred and be continuing. 

  
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 Section 5.02 Successor Substituted. 

If any Reorganization Event occurs that complies with Section 5.01(a)(ii) and 5.01(b) hereof, and the Company has complied with
Section 5.03 hereof: 
 (a) from and after the date of such Reorganization Event, the Reorganization Successor Company for
such Reorganization Event will succeed to, and be substituted for, and may exercise every right and power of, the Company under this Indenture with the same effect as if such Reorganization Successor Company had been named as the Company herein; and

 (b) except in the case of a Reorganization Event that is a conveyance, transfer or lease of all or substantially all of the
Company’s consolidated property and assets, the Person named as the “Company” in the first paragraph of this Indenture or any successor that will thereafter have become such in the manner prescribed in this Article 5 will be
released from its obligations under this Indenture and may be dissolved, wound up and liquidated at any time. 

Section 5.03 Opinion of Counsel to Be Given to Trustee. 

If the Company will not be the surviving corporation, at or prior to the effective date of the consolidation, merger, sale, conveyance,
transfer or lease, the Company shall deliver to the Trustee an Officer’s Certificate and an Opinion of Counsel as conclusive evidence that such consolidation, merger, sale, conveyance, transfer or lease and such assumption complies with the
provisions of this Article 5 and the supplemental indenture complies with the provisions of this Article 5 and Article 9 and that all conditions precedent herein provided for relating to such transaction have been complied with. For the avoidance of
doubt, the Trustee shall have no duty or obligation to determine whether the Company is the surviving corporation as a result of such consolidation, merger, sale, conveyance, transfer or lease. 

ARTICLE 6 

DEFAULTS AND REMEDIES 
 Section 6.01 Events of Default. 
 Each of the following events will be
an “Event of Default”: 
 (i) the Company fails to pay the principal of the Notes (including any Fundamental
Change Repurchase Price or Redemption Price) when due at maturity, upon Redemption, repurchase upon a Fundamental Change, declaration of acceleration or otherwise; 
 (ii) the Company fails to pay any interest on the Notes when due and such failure continues for a period of 30 days after the applicable due date; 

(iii) the Company fails to give any Fundamental Change Notice or notice of a Make-Whole Fundamental Change, in each case, when due and
such failure continues for a period of 5 days; 

  
 46 

 (iv) the Company fails to comply with its obligation to convert a Note in accordance with
Article 10 hereof upon a Holder’s exercise of its conversion rights with respect to such Note; 
 (v) the Company fails to
comply with its obligations under Article 5 hereof; 
 (vi) the Company fails to perform or observe any of its covenants or
warranties in this Indenture or in the Notes (other than a covenant or agreement specifically addressed in clauses (i) through (v) above) and such failure continues for a period of 60 days after (A) the Company receives notice of such
failure from the Trustee or (B) the Company and the Trustee receive written notice of such failure from Holders of at least 25% of the aggregate principal amount of then outstanding Notes; 

(vii) the default by the Company or any of the Significant Subsidiaries with respect to any mortgage, agreement or other instrument under
which there may be outstanding, or by which there may be secured or evidenced, any indebtedness for money borrowed by the Company and/or any of the Significant Subsidiaries in excess of $10,000,000 in the aggregate, whether such indebtedness exists
as of the Issue Date or is later created, if that default: 
 (A) results in such indebtedness becoming or being
declared due and payable (prior to its express maturity); or 
 (B) constitutes a failure to pay the principal
of, or interest on, such indebtedness when due and payable at its stated maturity, upon required repurchase, upon declaration or otherwise; 

and such acceleration shall not have been rescinded or annulled or such failure to pay cured within 30 days after written notice has been received by the
Company or such Significant Subsidiary from the Trustee or by the Trustee, the Company and such Significant Subsidiary from the Holders of at least 25% in principal amount of the Notes then outstanding. 

(viii) a final judgment for the payment of $10,000,000 or more (excluding any amounts covered by insurance) is rendered against the
Company or any of the Significant Subsidiaries, and such judgment is not discharged or stayed within 60 days after (i) the date on which all rights to appeal such judgment have expired if no appeal has commenced, or (ii) the date on which
all rights to appeal have been extinguished; 
 (ix) the Company or any Significant Subsidiary, pursuant to or within the
meaning of any Bankruptcy Law: 
 (A) commences a voluntary case; 

(B) consents to the entry of an order for relief against it in an involuntary case; 

(C) consents to the appointment of a Custodian of it or for any substantial part of its property; 

  
 47 

 (D) makes a general assignment for the benefit of its creditors; 

(E) takes any comparable action under any foreign laws relating to insolvency; or 

(F) generally is not paying its debts as they become due; or 

(x) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(A) is for relief against Company or any Significant Subsidiary in an involuntary case or proceeding; 

(B) appoints a Custodian of against Company or any Significant Subsidiary, or for any substantial part of the property of
the Company or any Significant Subsidiary; 
 (C) orders the winding up or liquidation of the Company or any
Significant Subsidiary; or 
 (D) grants any similar relief under any foreign laws; 

and, in each such case, the order or decree remains unstayed and in effect for 60 days. 

Section 6.02 Acceleration. 
 (a) Automatic Acceleration in Certain Circumstances. If an Event of Default specified in Sections 6.01(ix) or 6.01(x) hereof occurs with respect to the Company (but not any of the Significant
Subsidiaries), the principal amount of, and all accrued and unpaid interest, if any, on, all of the then outstanding Notes will immediately become due and payable without any further action or notice by any party. 

(b) Optional Acceleration. If any Event of Default (other than an Event of Default specified in Sections 6.01(ix) or 6.01(x)
hereof with respect to the Company) occurs and is continuing, the Trustee or the Holders of at least 25% in aggregate principal amount of the Notes then outstanding may declare the principal amount of, and all accrued and unpaid interest, if any, on
all then outstanding Notes to be immediately due and payable by delivering written notice to the Company, and upon such declaration, the principal amount of, and all accrued and unpaid interest, if any, on all then outstanding Notes will immediately
become due and payable. 
 (c) Rescission of Acceleration. Notwithstanding anything to the contrary in this Indenture,
the Holders of a majority of the aggregate principal amount of the then outstanding Notes may, on behalf of the Holders of all of the then outstanding Notes, rescind any acceleration of the Notes and its consequences hereunder by delivering written
notice to the Trustee if (i) such rescission would not conflict with any judgment or decree of a court of competent jurisdiction and (ii) any and all existing Events of Default, other than the nonpayment of the principal of, the
Fundamental Change Repurchase Price or the Redemption Price for, or any interest on, the Notes that has become due solely as a result of acceleration, have been cured 

  
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or waived. No such rescission will affect any subsequent Default or impair any right consequent thereto. 
 Section 6.03 Other Remedies. 
 If an Event of Default occurs and is
continuing, the Trustee may pursue any available remedy to collect the payment of principal, accrued and unpaid interest, if any, or payment of the Fundamental Change Repurchase Price or Redemption Price for, the Notes or to enforce the performance
of any provision of the Notes or this Indenture regarding any other matter. 
 The Trustee may maintain a proceeding even if it
does not possess any of the Notes or does not produce any of the Notes in the proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy accruing upon an Event of Default will not impair the right or remedy or
constitute a waiver of or acquiescence in the Event of Default. No remedy is exclusive of any other remedy. All available remedies are cumulative. 
 Section 6.04 Sole Remedy for Failure to Report. 

(a) General. Notwithstanding anything to the contrary in the Notes or in this Indenture, the Company may elect
that the sole remedy for any Event of Default specified in Section 6.01(vi) hereof relating to the Company’s failure to comply with the reporting obligations under Section 4.02 or 4.03 hereof (a “Reporting Event of
Default”) will, for the period beginning on the date on which such Reporting Event of Default first occurred and ending on the earlier of (A) the date on which such Reporting Event of Default is cured or validly waived in accordance
with Section 6.05 hereof and (B) the 270th
calendar day immediately following the date on which such Reporting Event of Default first occurred, consist exclusively of the right to receive additional interest (the “Extension Fee”) on the Notes at a rate equal to
0.50% per annum on the principal amount of the then outstanding Notes. If the Company elects, the Extension Fee will be payable in the same manner and on the same dates as the stated interest payable on the Notes. The Extension Fee will accrue
in addition to any Additional Interest that the Company is obligated to pay under Section 4.04 hereof. 

(b) Limitation on Remedy. If (i) a Reporting Event of Default occurs and the Company elects that the sole
remedy with respect to such Reporting Event of Default will be the Extension Fee and (ii) on the 271st day immediately following, and including, the date on which such Reporting Event of Default first occurred, such Reporting Event of Default has not been cured or validly waived in accordance with
Section 6.05 hereof, then the Notes will become subject to acceleration under Section 6.02(b) hereof on account of such Reporting Event of Default. 
 (c) Company Election Notice. To elect to pay the Extension Fee as the sole remedy for a Reporting Event of Default, the Company must deliver written notice of such election to the Holders, the
Paying Agent and the Trustee prior to the date on which such Reporting Event of Default first occurs. Any such notice must include a brief description of the report or reports that the Company failed to file that caused such Reporting Event of
Default, a statement that the Company is electing to pay the Extension Fee and the date on which such Reporting Event of Default will occur. 

  
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 If a Reporting Event of Default occurs and the Company fails to timely deliver such notice
for such Reporting Event of Default, the Notes will be subject to acceleration under Section 6.02(b) hereof on account of such Reporting Event of Default. 
 (d) Other Events of Default. Notwithstanding anything to the contrary herein, if the Company elects to pay the Extension Fee with respect to any Reporting Event of Default, the Company’s
election will not affect the rights of any Holder with respect to any other Event of Default. For the avoidance of doubt, in no event will the Company be obligated to pay the Extension Fee at a rate greater than 0.50% per annum on the principal
amount of then outstanding Notes, regardless of the number of events or circumstances giving rise to requirements to pay such Extension Fee. 
 Section 6.05 Waiver of Past Defaults. 
 If an Event of Default
described in Sections 6.01(i), 6.01(ii), 6.01(iv) or 6.01(vi) (which, in the case of Section 6.01(vi) only, relates to a covenant that cannot be amended without the consent of each affected Holder) or a Default that would lead to such an Event
of Default occurs and is continuing, such Event of Default or Default may be waived only with the consent of each affected Holder. Every other Event of Default or Default may be waived by the Holders of a majority of the aggregate principal amount
of then outstanding Notes. Whenever any Event of Default is so waived, it will cease to exist, and whenever any Default is so waived, it will be deemed cured and any Event of Default arising therefrom will be deemed not to occur. However, no such
waiver will extend to any subsequent or other Default or Event of Default or impair any consequent right. 

Section 6.06 Control by Majority. 
 At any time, the Holders of a majority of the aggregate principal amount of then outstanding Notes may direct the time, method and place of conducting any proceeding for any remedy available to the
Trustee or for exercising any trust or power conferred on the Trustee with respect to the Notes. However, the Trustee may refuse to follow any direction that conflicts with law or this Indenture or, subject to Section 7.01 hereof, that the
Trustee determines to be unduly prejudicial to the rights of any other Holder or that would potentially involve the Trustee in personal liability. Prior to taking any action hereunder, the Trustee will be entitled to indemnification reasonably
satisfactory to it against all losses and expenses caused by taking or not taking such action. 
 Section 6.07
Limitation on Suits. 
 Except to enforce (i) its rights to receive the principal of, the Fundamental Change
Repurchase Price or the Redemption Price for, interest, if any, on, a Note, or (ii) the failure of the Company to comply with its obligations under Article 10 to convert any Note, no Holder may pursue a remedy with respect to this Indenture or
the Notes unless: 
 (a) such Holder has delivered to the Trustee written notice that an Event of Default has occurred and is
continuing; 

  
 50 

 (b) the Holders of at least 25% of the aggregate principal amount of then outstanding Notes
deliver to the Trustee a written request that the Trustee pursue a remedy with respect to such Event of Default; 
 (c) such
Holder or Holders have offered and provided, to the Trustee security or indemnity reasonably satisfactory to the Trustee against any loss, liability or other expense of compliance with such written request; 

(d) the Trustee has not complied with such written request within 60 days after receipt of such written request and offer of security or
indemnity; and 
 (e) during such 60-day period, the Holders of a majority of the aggregate principal amount of then outstanding
Notes did not deliver to the Trustee a direction inconsistent with such written request. 
 A Holder may not use this Indenture
to prejudice the rights of any other Holder or to obtain a preference or priority over any other Holder, it being understood that the Trustee does not have any affirmative duty to ascertain whether any usage of this Indenture by a Holder is unduly
prejudicial to such other Holders. 
 Section 6.08 Rights of Holders To Receive Payment. 

Notwithstanding any other provision of this Indenture, the right of any Holder to receive payment of the principal of, the Fundamental
Change Repurchase Price or the Redemption Price for, accrued and unpaid interest, if any, on, and any consideration due under Article 10 upon conversion of, its Note, on or after the respective due date, or to bring suit for the enforcement of any
such payment and/or delivery on or after the respective due date, will not be impaired or affected without the consent of such Holder and will not be subject to the requirements of Section 6.07 hereof. 

Section 6.09 Collection Suit by Trustee. 
 If an Event of Default specified in Section 6.01(i), 6.01(ii) or 6.01(iv) hereof occurs and is continuing, the Trustee is authorized to recover judgment in its own name and as trustee of an
express trust against the Company for the whole amount of principal of, the Fundamental Change Repurchase Price or the Redemption Price for, and interest, if any, on, the Notes, and such further amount as is sufficient to cover the costs and
expenses of collection provided for under Section 7.06 hereof. 
 Section 6.10 Trustee May File Proofs of
Claim. 
 The Trustee is authorized to file such proofs of claim and other papers or documents as may be necessary or
advisable to have the claims of the Trustee and the Holders allowed in any judicial proceedings relative to the Company, its creditors or its property and, unless prohibited by law or applicable regulations, will be entitled to collect, receive and
distribute any money or other property payable or deliverable on any such claims, and any Custodian in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee, and in the event that the Trustee consents
to the making of such payments directly to the Holders, to pay to 

  
 51 

 
the Trustee any amount due to it for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under
Section 7.06 hereof. To the extent that the payment of any such compensation, expenses, disbursements and advances of the Trustee, its agents and counsel, and any other amounts due the Trustee under Section 7.06 hereof out of the estate in
any such proceeding, will be denied for any reason, payment of the same will be secured by a lien on, and will be paid out of, any and all distributions, dividends, money, securities and other properties that the Holders may be entitled to receive
in such proceeding whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing herein contained will be deemed to authorize the Trustee to authorize or consent to, or to accept or to adopt on behalf of any Holder,
any plan of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any Holder, or to authorize the Trustee to vote in respect of the claim of any Holder in any such proceeding. 

Section 6.11 Priorities. 
 If the Trustee collects any money or property pursuant to this Article 6, it will pay out the money or property in the following order: 

FIRST: to the Trustee, its agents and attorneys for amounts due under Section 7.06 hereof, including payment of all compensation,
expenses and liabilities incurred, and all advances made, by the Trustee and the costs and expenses of collection; 
 SECOND: to
the Holders, for any amounts due and unpaid on the principal of, the Fundamental Change Repurchase Price or the Redemption Price for, accrued and unpaid interest, if any, on, and any cash due upon the conversion of, any Note, without preference or
priority of any kind, according to such amounts due and payable on all of the Notes; and 
 THIRD: the balance, if any, to the
Company or to such other party as a court of competent jurisdiction directs. 
 The Trustee may fix a record date and payment
date for any payment to the Holders pursuant to this Section 6.11. If the Trustee so fixes a record date and a payment date, at least 15 days prior to such record date, the Company will deliver to each Holder and the Trustee a written notice,
which notice will state such record date, such payment date and the amount of such payment. 
 Section 6.12 Undertaking
for Costs. 
 In any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee
for any action taken or omitted by it as Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs,
including reasonable attorneys’ fees and expenses, against any party litigant in the suit, having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 6.12 does not apply to a suit by
the Trustee, a suit by a Holder pursuant to Section 6.08 hereof or a suit by Holders of more than 10% in aggregate principal amount of the then outstanding Notes. 

  
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 ARTICLE 7 
 TRUSTEE 
 Section 7.01 Duties of Trustee. 

(a) If an Event of Default has occurred and is continuing, the Trustee will exercise the rights and powers vested in it by this
Indenture, and use the same degree of care and skill in its exercise as a prudent Person would exercise or use under the circumstances in the conduct of such Person’s own affairs. 

(b) Except during the continuance of an Event of Default: 
 (i) the Trustee undertakes to perform such duties, and only such duties, as are specifically set forth in this Indenture, and no implied covenants or obligations will be read into this Indenture against
the Trustee; and 
 (ii) in the absence of bad faith on its part, as to the truth of the statements and the correctness of the
opinions expressed therein, the Trustee may conclusively rely upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture. 
 (c) The Trustee may not be relieved from liabilities for its own negligent action, its own negligent failure to act, or its own willful misconduct, except that: 

(i) this paragraph does not limit the effect of Section 7.01(b) hereof; 

(ii) the Trustee will not be liable for any error of judgment made in good faith by a Trust Officer unless it is proved that the Trustee
was negligent in ascertaining the pertinent facts; and 
 (iii) the Trustee will not be liable with respect to any action it
takes or omits to take in good faith in accordance with a direction received by it pursuant to Sections 6.06, 12.03 or 12.04 hereof. 
 (d) Whether herein expressly so provided, every provision of this Indenture that in any way relates to the Trustee is subject to Sections 7.01(a), (b) and (c) hereof. 

(e) The Trustee will not be liable for interest on any money received by it hereunder or risk or expend any of its own funds. 

(f) Money or shares of Common Stock held in trust by the Trustee need not be segregated from other funds except to the extent required by
law. 
 (g) No provision of this Indenture will require the Trustee to expend or risk its own funds or otherwise incur financial
liability in the performance of any of its duties hereunder or in the exercise of any of its rights or powers. 

  
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 (h) Every provision of this Indenture relating to the conduct or affecting the liability of
or affording protection to the Trustee will be subject to the provisions of this Article 7, and the provisions of this Article 7 will apply to the Trustee, Registrar, Paying Agent and Conversion Agent. 

(i) The Trustee will not be deemed to have notice of a Default or an Event of Default unless (i) a Trust Officer of the Trustee has
received written notice of any event which is in fact such a Default at its Corporate Trust Office thereof from the Company or any Holder, and such notice references the Notes and this Indenture or (ii) a Trust Officer has actual knowledge
thereof. 
 Section 7.02 Rights of Trustee. 

(a) The Trustee may conclusively rely and shall be protected in acting or refraining from acting upon any document, including, but not
limited to any resolution, certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness believed by it to be genuine and to have been signed or presented by
the proper person. The Trustee need not investigate any fact or matter stated in the document. The Trustee may, however, in its discretion make such further inquiry or investigation into such facts or matters as it may see fit and, if the Trustee
determines to make such further inquiry or investigation, it will be entitled to examine the books, records and premises of the Company, personally or by agent or attorney and at the expense of the Company, and will incur no liability of any kind by
reason of such inquiry or investigation. 
 (b) Before the Trustee acts or refrains from acting, shall be entitled to receive an
Officer’s Certificate or an Opinion of Counsel or both. The Trustee will not be liable for any action it takes or omits to take in good faith in conclusive reliance on the Officer’s Certificate or Opinion of Counsel. Notwithstanding this
Section 7.02(b), no Opinion of Counsel will be required in connection with the removal of the Restricted Notes Legend on or after the Free Trade Date. 
 (c) The Trustee may execute any of the trusts or powers hereunder or perform any duties hereunder either directly or by or through agents, attorneys or custodians and will not be responsible for the
misconduct or negligence of any agent, attorney or custodian appointed with due care. 
 (d) So long as the Trustee’s
conduct does not constitute willful misconduct or negligence, the Trustee will not be liable for any action it takes or omits to take in good faith that it believes to be authorized or within the rights or powers conferred upon it by this Indenture.

 (e) The Trustee may consult with counsel of its own selection, and the advice or any Opinion of Counsel with respect to legal
matters relating to this Indenture and the Notes will be full and complete authorization and protection from liability in respect to any action taken, omitted or suffered by it hereunder in good faith and in reliance thereon. 

(f) The permissive rights of the Trustee to do things enumerated in this Indenture will not be construed as a duty unless so specified
herein. 

  
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 (g) The Trustee will be under no obligation to exercise any of the rights or powers vested
in it by this Indenture at the request or direction of any of the Holders pursuant to this Indenture, unless such Holders have offered to the Trustee security or indemnity reasonably satisfactory to the Trustee against the costs, expenses and
liabilities that might be incurred by it in compliance with such request or direction. 
 (h) The rights, privileges,
protections, immunities and benefits given to the Trustee, including its right to be indemnified, are extended to, and will be enforceable by, the Trustee in each of its capacities hereunder, and each agent, custodian and other Person employed to
act hereunder, including the Registrar, Paying Agent and Conversion Agent. 
 (i) The Trustee may request that the Company
deliver a certificate setting forth the names of individuals and/or titles of officers authorized at such time to take specified actions pursuant to this Indenture. 
 (j) In no event will the Trustee be responsible or liable for special, indirect, punitive or consequential loss or damage of any kind whatsoever (including, but not limited to, loss of profit)
irrespective of whether the Trustee has been advised of the likelihood of such loss or damage and regardless of the form of action. 
 (k) The Trustee shall not be required to give any bond or surety in respect of the performance of its powers and duties hereunder. 
 (l) Any request or direction of the Company mentioned herein shall be sufficiently evidenced by a Company Order and any resolution of the Board of Directors may be sufficiently evidenced by a Board
Resolution. 
 Section 7.03 Individual Rights of Trustee. 

The Trustee in its individual or any other capacity may become the owner or pledgee of Notes and may otherwise deal with the Company or
its Affiliates with the same rights it would have if it were not Trustee. However, if the Trustee acquires any conflicting interest it must eliminate the conflict within 90 days or resign. Any Paying Agent, Registrar, Conversion Agent or
co-registrar may do the same with like rights. However, the Trustee must comply with Sections 7.09 and 7.11 hereof. 

Section 7.04 Trustee’s Disclaimer. 
 The Trustee will not be responsible for and makes no representation as to the validity, priority or adequacy of this Indenture or the Notes, it will not be accountable for the Company’s use of the
proceeds from the Notes, and it will not be responsible for any statement of the Company in this Indenture or in any document issued in connection with the sale of the Notes or in the Notes other than the Trustee’s certificate of
authentication. Neither the Trustee nor any authenticating agent shall be accountable for the use or application by the Company of any Notes of the proceeds thereof. 

  
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 Section 7.05 Notice of Defaults. 

If a Default or Event of Default occurs and is continuing and is known to the Trustee, the Trustee will send to each Holder notice of the
Default or Event of Default within 90 days after such Default or Event of Default first occurs, or, if it is not known to the Trustee within 90 days, as soon as practicable after it is known to the Trustee; provided, however, that
except in the case of a Default or Event of Default that is, or would lead to an Event of Default, described in Section 6.01(i), 6.01(ii) or 6.01(iv) hereof, the Trustee may withhold the notice if and so long as it in good faith determines that
withholding the notice is in the interests of Holders. 
 Section 7.06 Compensation and Indemnity 

(a) The Company will pay to the Trustee, from time to time, such compensation as will be agreed upon, from time to time, in writing for
its services. The Trustee’s compensation will not be limited by any law on compensation of a trustee of an express trust. The Company will reimburse the Trustee for all reasonable fees and expenses incurred or made by it, including costs of
collection, in addition to the compensation for its services. Such expenses will include the reasonable compensation, fees and expenses, disbursements and advances of the Trustee’s agents, counsel, accountants and experts. The Company will
fully indemnify the Trustee against any and all loss, liability, claim, damage or expense (including (i) reasonable attorneys’ fees and expenses and (ii) taxes, other than taxes based upon, measured by or determined by the income of
the Trustee) incurred by it in connection with the acceptance and administration of this trust and the performance of its duties hereunder, including the costs and expenses of defending itself against any claim (whether asserted by the Company, any
Holder or any other Person). The Trustee will notify the Company promptly of any claim for which it may seek indemnity. Failure by the Trustee to so notify the Company of any claim for which it may seek indemnity of which a Trust Officer has
actually received written notice will not relieve the Company of its obligations hereunder except to the extent such failure will have materially prejudiced the Company. The Company will defend the claim and the Trustee will cooperate in the
defense. If the Trustee is advised by counsel in writing that it may have available to it defenses that are in conflict with the defenses available to the Company, then the Trustee may have separate counsel, and the Company will pay the reasonable
fees and expenses of such counsel. The Company need not reimburse any expense or indemnify against any loss, liability or expense incurred by the Trustee through the Trustee’s own willful misconduct or negligence. The Company need not pay for
any settlement made by the Trustee without the Company’s consent, such consent not to be unreasonably withheld. All indemnifications and releases from liability granted hereunder to the Trustee will extend to its officers, directors, employees,
agents, attorneys, custodians, successors and assigns. 
 (b) The Company’s payment obligations pursuant to this
Section 7.06 will survive the resignation or removal of the Trustee and the discharge of this Indenture. If the Trustee incurs expenses after the occurrence of a Default specified in Sections 6.01(ix) or 6.01(x) hereof with respect to the
Company, the expenses are intended to constitute expenses of administration under the Bankruptcy Law. 

  
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 Section 7.07 Replacement of Trustee. 

(a) The Trustee may resign at any time by notifying the Company, in writing, at least 30 days prior to the proposed resignation. The
Holders of a majority in aggregate principal amount of then outstanding Notes may remove the Trustee by notifying the Trustee, in writing. The Company may remove the Trustee if: 

(i) the Trustee fails to comply with Section 7.09 hereof; 
 (ii) the Trustee is adjudged bankrupt or insolvent; 
 (iii) a receiver or other
public officer takes charge of the Trustee or its property; or 
 (iv) the Trustee otherwise becomes incapable of acting.

 (b) If the Trustee resigns, is removed by the Company or by the Holders of a majority in aggregate principal amount of the
Notes then outstanding, or if a vacancy exists in the office of Trustee for any reason (the Trustee in such event being referred to herein as the retiring Trustee), the Company will promptly appoint a successor Trustee. 

(c) A successor Trustee will deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Thereupon, the
resignation or removal of the retiring Trustee will become effective, and the successor Trustee will have all the rights, powers and duties of the Trustee under this Indenture. The successor Trustee will send a notice of its succession to Holders.
The retiring Trustee will, upon payment of all of its costs and the costs of its agents and counsel, promptly transfer all property held by it as Trustee to the successor Trustee. 

(d) If a successor Trustee does not take office within 60 days after the retiring Trustee resigns or is removed, the retiring Trustee,
the Company or the Holders of at least 10% of the aggregate principal amount of the Notes then outstanding may petition, at the expense of the Company, any court of competent jurisdiction for the appointment of a successor Trustee. 

(e) If the Trustee, after written request by any Holder, fails to comply with Section 7.09 hereof, such Holder may petition any
court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 
 (f)
Notwithstanding the replacement of the Trustee pursuant to this Section 7.07, the Company’s obligations under Section 7.06 hereof will continue for the benefit of the retiring Trustee. 

Section 7.08 Successor Trustee by Merger. 
 (a) If the Trustee consolidates with, merges or converts into, or transfers all or substantially all its corporate trust business or assets to, another corporation or banking association, the resulting,
surviving or transferee corporation or banking association without any further act will be the successor Trustee. 

  
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 (b) In case at the time such successor or successors by merger, conversion or consolidation
to the Trustee succeeds to the trusts created by this Indenture, any of the Notes have been authenticated, but not delivered, any such successor to the Trustee may adopt the certificate of authentication of any predecessor trustee, and deliver such
Notes so authenticated; and, in case at that time any of the Notes have not been authenticated, any such successor to the Trustee may authenticate such Notes, either in the name of any predecessor hereunder or in the name of the successor to the
Trustee. 
 Section 7.09 Eligibility; Disqualification. 

The Trustee will have (or, in the case of a corporation included in a bank holding company system, the related bank holding company will
have) a combined capital and surplus of at least $50,000,000, as set forth in its (or its related bank holding company’s) most recent published annual report of condition. 

Section 7.10 Trustee’s Application for Instructions from the Company. 

Any application by the Trustee for written instructions from the Company may, at the option of the Trustee, set forth in writing any
action proposed to be taken or omitted by the Trustee under this Indenture and the date on and/or after which such action will be taken or such omission will be effective. The Trustee will not be liable to the Company for any action taken by, or
omission of, the Trustee in accordance with a proposal included in such application on or after the date specified in such application (which date will not be less than three Business Days after the date any Officer actually receives such
application, unless any such Officer has consented in writing to any earlier date), unless prior to taking any such action (or the effective date in the case of any omission), the Trustee has received written instructions in response to such
application specifying the action to be taken or omitted. 
 ARTICLE 8 

SATISFACTION AND DISCHARGE 
 Section 8.01 Discharge of Liability on Notes. 
 When (a)(i) the
Company delivers to the Registrar all outstanding Notes (other than Notes replaced pursuant to Section 2.11 hereof) for cancellation or (ii) all outstanding Notes have become due and payable, whether at the Maturity Date, any Redemption
Date or Fundamental Change Repurchase Date, or upon conversion or otherwise, and the Company irrevocably deposits with the Trustee or delivers to the Holders, as applicable, cash and/or shares of Common Stock and cash (in lieu of fractional shares
of Common Stock) (solely to satisfy amounts due and owing as a result of conversions of the Notes), sufficient to pay all amounts due and owing on all outstanding Notes (other than Notes replaced pursuant to Section 2.11 hereof), (b) the
Company pays all other sums payable by it under this Indenture with respect to the then outstanding Notes and (c) upon demand of the Company, the Company delivers to the Trustee an Officer’s Certificate and an Opinion of Counsel, each
stating that all of the applicable conditions precedent to the discharge of this Indenture described in this section have been satisfied, then, subject to Section 7.06 hereof, this Indenture will cease to be of further effect with respect to
the 

  
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Notes and the Holders and the Trustee will acknowledge the satisfaction and discharge of this Indenture with respect to the Notes. 

Notwithstanding the satisfaction and discharge of this Indenture, (i) any obligation of the Company to any Holder under Article 10
hereof with respect to the conversion of any Note or to the Trustee under Section 7.1 hereof with respect to compensation or indemnity, and (ii) any obligation of the Trustee with respect to money deposited with the Trustee under this
Article 8 and Section 12.02 hereof will survive. 
 Section 8.02 Repayment to the Company. 

Subject to any applicable unclaimed property law, the Trustee and the Paying Agent, upon receiving a written request from the Company,
will promptly turn over to the Company any cash or securities, including shares of Common Stock, held for payment on the Notes that remains unclaimed two years after the date on which such payment was due. After the Trustee and the Paying Agent
return such cash and securities, including shares of the Common Stock, to the Company, the Trustee and the Paying Agent will have no further liability to any Holder with respect to such cash and securities, including shares of Common Stock, and any
Holder entitled to the payment of such cash or securities, including shares of Common Stock, under the Notes or this Indenture must look to the Company for payment as a general creditor of the Company. 

ARTICLE 9 

AMENDMENTS, SUPPLEMENTS AND WAIVERS 
 Section 9.01 Without Consent of Holders. 
 The Company and the Trustee
may amend or supplement this Indenture or the Notes without the consent of any Holder: 
 (a) to add guarantees with respect to
the Company’s obligations under this Indenture or the Notes; 
 (b) to secure the Notes; 

(c) to provide for the assumption of the Company’s obligations under this Indenture and under the Notes by a Reorganization
Successor Corporation as described in Article 5 hereof; 
 (d) to provide for the assumption of the Company’s obligations
under this Indenture and under the Notes by a Merger Successor Corporation as described in Section 10.08 or to modify the conversion rights of the Holders in accordance with Section 10.08 hereof upon the occurrence of a Merger Event;

 (e) to provide for the conversion of the Notes into Reference Property and effect any other changes to the terms of the Notes
required in connection therewith; 
 (f) to surrender any right or power conferred upon the Company under this Indenture;

  
 59 

 (g) to add to the Company’s covenants or events of default for the benefit of the
Holders; 
 (h) to cure any ambiguity or correct any inconsistency or defect in this Indenture or in the Notes; 

(i) to modify or amend the Indenture to permit the qualification of the Indenture or any supplemental indenture under the TIA as then in
effect; 
 (j) to evidence the acceptance of appointment by a successor Trustee with respect to this Indenture; 

(k) to make any other change that would not reasonably be expected to adversely affect the interests of any Holder of the Notes;

 (l) to comply with the rules of any applicable Depositary; and 

(m) to conform the provisions of this Indenture and the form or terms of the Notes to the “Description of Notes” section of the
Preliminary Offering Memorandum, as supplemented by the Pricing Termsheet. 
 Section 9.02 With Consent of Holders.

 With the written consent of the Holders of at least a majority of the aggregate principal amount of the Notes then
outstanding (including, without limitation, consents obtained in connection with a repurchase of, or tender offer or exchange offer for, Notes), by Act of such Holders delivered to the Company and the Trustee, the Company, when authorized by a Board
Resolution, may amend or supplement this Indenture or the Notes, or waive any past Default or Event of Default or compliance with any provision of this Indenture or the Notes; provided, however, that, without the consent of each
affected Holder, no amendment or supplement to this Indenture or the Notes, or waiver of any provision of this Indenture or the Notes, may: 
 (a) reduce the principal amount of, or change the Maturity Date of, any Note; 

(b) reduce the rate of, or extend the stated time for payment of, interest on any Note; 

(c) reduce the Fundamental Change Repurchase Price or the Redemption Price of any Note or change the time at which, or the circumstances
under which, the Notes may, or will be, redeemed or repurchased; 
 (d) impair the right of any Holder to institute suit for any
payment on any Note, including with respect to any consideration due upon conversion of a Note; 
 (e) make any Note payable in
a currency other than that stated in the Note; 
 (f) impair the conversion rights of any Holder under Article 10 hereof or
otherwise reduces the number of shares of Common Stock, amount of cash or any other property receivable by a Holder upon conversion; 

  
 60 

 (g) change the ranking of the Notes; 

(h) reduce any voting requirements included in this Indenture; 
 (i) make any change to any amendment, modification or waiver provision of this Indenture that requires the consent of each affected Holder; or 

(j) reduce the percentage of the aggregate principal amount of then outstanding Notes whose Holders must consent to an amendment of this
Indenture or a waiver of a past Default. 
 It will not be necessary for the consent of the Holders under this Section 9.02
to approve the particular form of any proposed amendment, but it will be sufficient if such consent approves the substance of such proposed amendment. 
 Section 9.03 Execution of Supplemental Indentures. 
 Upon the request
of the Company, the Trustee will sign any supplemental indenture authorized pursuant to this Article 9 if the amendment contained therein does not affect the rights, duties, liabilities or immunities of the Trustee under this Indenture. If the
supplemental indenture adversely affects the Trustee’s rights, duties, liabilities or immunities under this Indenture, then the Trustee may, but need not, sign such supplemental indenture. In executing any such supplemental indenture, the
Trustee will be provided with, and, subject to the provisions of Section 7.01 hereof, will be fully protected in conclusively relying upon, an Officer’s Certificate and an Opinion of Counsel stating that such supplemental indenture is
authorized and permitted under this Indenture and constitutes the valid and binding obligation of the Company, enforceable against the Company in accordance with its terms. 
 Section 9.04 Notices of Supplemental Indentures. 
 After an amendment
or supplement to this Indenture or the Notes pursuant to Sections 9.01 or 9.02 hereof becomes effective, the Company will promptly deliver written notice to the Trustee, which notice will briefly describe the substance of such amendment or
supplement to this Indenture in reasonable detail and state the effective date of such amendment or supplement. The Company, or the Trustee, at the direction of the Company, will then promptly deliver a copy of such notice to each Holder. The
failure to deliver such notice to each Holder, or any defect in such notice, will not impair or affect the validity of such amendment or supplement to this Indenture. 
 Section 9.05 Effect of Supplemental Indentures. 
 Upon the execution
of any supplemental indenture under this Article 9: 
 (a) this Indenture will be modified in accordance therewith; 

(b) such supplemental indenture will form a part of this Indenture for all purposes; and 

  
 61 

 (c) every Holder of Notes theretofore, or thereafter, authenticated and delivered hereunder
will be bound thereby. 
 Section 9.06 Revocation and Effect of Consents, Waivers and Actions. 

(a) Revocation. Until an amendment, supplement or waiver becomes effective, a consent to it by a Holder is a continuing consent by
the Holder, and every subsequent Holder of a Note or portion of a Note that evidences the same debt as the consenting Holder’s Note, even if notation of the consent is not made on any Note. However, any such Holder, or subsequent Holder, may
revoke the consent as to its Note or portion of a Note if the Trustee receives the notice of revocation before the date the amendment, supplement or waiver becomes effective. 
 (b) Regular Record Dates. The Company may, but is not obligated to, fix a record date for the purpose of determining the Holders entitled to give their consent or take any other action described
above or required, or permitted, to be taken pursuant to this Indenture. If a record date is fixed, then those Persons who were Holders at such record date (or their duly designated proxies), and only those Persons, will be entitled to give such
consent, to revoke any consent previously given or to take any such action, regardless of whether such Persons continue to be Holders after such record date. No such consent will be valid or effective for more than 120 days after such record date.

 (c) Binding Effect. After an amendment, supplement or waiver becomes effective, it will bind every applicable Holder.
Any amendment or supplement will become effective in accordance with the terms of the supplemental indenture relating thereto, which will become effective upon the execution thereof by the Trustee. 

Section 9.07 Notation on, or Exchange of, Notes. 
 If any amendment, supplement or waiver changes the terms of a Note, the Trustee may require the Holder of such Note to deliver such Note to the Trustee. The Trustee may place an appropriate notation on
such Note about the changed terms and return it to the Holder. Alternatively, if the Company or the Trustee so determines, the Company, in exchange for the Note, will issue and the Trustee will authenticate a new Note that reflects the changed
terms. 
 ARTICLE 10 
 CONVERSIONS 
 Section 10.01 Right To Convert. 

(a) In General. Subject to, and upon compliance with, the provisions of this Article 10, until the Close of Business on the third
Business Day immediately preceding the Maturity Date, a Holder may, at its option, convert all of its Notes, or any portion of its Notes having a principal amount equal to $1,000 or an integral multiple of $1,000 in excess thereof, into a number of
shares of Common Stock and an amount of cash in lieu of fractional shares of Common Stock, all as determined in accordance with Section 10.03 hereof. Notes may not be converted after the Close of Business on the third Business Day immediately
preceding the Maturity Date. 

  
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 (b) Closed Periods. Notwithstanding anything to the contrary in this Indenture,
(i) if the Company calls the Notes for redemption in accordance with Article 11 hereof, a Holder may not convert its Notes after the Close of Business on the third Business Day immediately preceding the applicable Redemption Date except to the
extent the Company fails to pay the Redemption Price for such Notes in accordance with Section 11.05 hereof, and (ii) if a Holder tenders a Repurchase Notice with respect to its Notes in accordance with Article 3 hereof, such Notes may not
be converted except to the extent (A) such Notes are not subject to such Repurchase Notice; (B) such Repurchase Notice is withdrawn in accordance with Article 3 hereof; or (C) the Company fails to pay the Fundamental Change Repurchase
for such Notes in accordance with Section 3.08 hereof. 
 Section 10.02 Conversion Procedures. 

(a) General. To exercise its conversion right with respect to a beneficial interest in a Global Note, the owner of such beneficial
interest must (i) comply with the Applicable Procedures for converting such beneficial interest; (ii) pay any funds equal to interest payable on the next Interest Payment Date that such Holder is required to pay under clause (d) of
this Section 10.02; and (iii) pay any transfer or similar taxes or duties that such Holder is required to pay under the proviso to clause (e) of this Section 10.02. 

To exercise its conversion right with respect to a Definitive Note, the Holder of such Note must (i) complete and manually sign the
conversion notice on the back of the Note, or a facsimile of such conversion notice (such notice, or such facsimile, the “Conversion Notice”); (ii) deliver such signed and completed Conversion Notice, which is irrevocable, and
such Note to the Conversion Agent at its office; (iii) furnish any endorsements and transfer documents that the Company, Conversion Agent, Trustee or Transfer Agent may require; (iv) pay any funds equal to interest payable on the next
Interest Payment Date that such Holder is required to pay under clause (d) of this Section 10.02; and (v) pay any transfer or similar taxes or duties that such Holder is required to pay under the proviso to clause (e) of this
Section 10.02. 
 The first Business Day on which a Holder satisfies the foregoing requirements with respect to a Note and
on which conversion of such Note is not otherwise prohibited under this Indenture will be the “Conversion Date” for such Note. 
 The conversion of any Note will be deemed to occur at the Close of Business on the Conversion Date for such Note, and any converted Note or portion thereof will cease to be outstanding upon conversion.

 (b) Holder of Record. If a Holder surrenders the entire principal amount of a Note for conversion, such Person will no
longer be the Holder of such Note as of the Close of Business on the Conversion Date for such Note. 
 Upon the conversion of a
Note, the Person in whose name such shares of Common Stock will be registered will become the holder of record of such shares of Common Stock at the Close of Business on the Conversion Date for such Note. 

(c) Conversions in Part. If a Holder surrenders only a portion of the principal amount of a Definitive Note for conversion,
promptly after the Conversion Date for such portion, 

  
 63 

 
the Company will, in accordance with Section 2.05 hereof, execute and deliver to the Trustee, and the Trustee will, upon receipt of a Company Order, in accordance with Section 2.05
hereof, authenticate and deliver to such Holder a new Definitive Note in an authorized denomination, having a principal amount equal to the aggregate principal amount of the unconverted portion of the Definitive Note surrendered for conversion and
bearing registration numbers not contemporaneously outstanding and any restrictive legends that such Definitive Note must bear under Section 2.10 hereof. 
 Upon the conversion of any beneficial interest in a Global Note, the Conversion Agent will promptly request that the Trustee make a notation on the “Schedule of Increases and Decreases of Global
Note” of such Global Note to reduce the principal amount represented by such Global Note by the principal amount of the converted beneficial interest. If all of the beneficial interests in a Global Note are so converted, such Global Note will
be deemed surrendered to the Trustee for cancellation, and the Trustee will cause such Global Note to be cancelled in accordance with the Applicable Procedures. 
 (d) Reimbursement of Interest upon Conversion. If a Holder converts a Note after the Close of Business on a Regular Record Date, but prior to the Open of Business on the Interest Payment
Date corresponding to such Regular Record Date, such Holder must accompany such Note with an amount of cash equal to the amount of interest, if any, that will be payable on such Note on the corresponding Interest Payment Date; provided,
however, that a Holder need not make such payment (A) for conversions following the Regular Record Date immediately preceding the Maturity Date; (B) if the Company has specified a Fundamental Change Repurchase Date that is after a
Regular Record Date and on or prior to the Business Day immediately following the corresponding Interest Payment Date and the Holder converts its Note after the Close of Business on such Regular Record Date and on or prior to the Open of Business on
such Interest Payment Date; (C) if the Company has specified a Redemption Date that is after a Regular Record Date and on or prior to the Business Day immediately following the Interest Payment Date corresponding to such Regular Record Date and
such Holder surrenders such Note for conversion after such Regular Record Date and on or prior to the Open of Business on such Interest Payment Date; or (D) to the extent of any overdue interest, if any overdue interest exists at the time of
conversion with respect to such Note. 
 (e) Taxes and Duties. If a Holder converts a Note, the Company will pay
any documentary, stamp or similar issue or transfer tax due on the issue of any shares of the Common Stock upon the conversion; provided, however, that if any tax is due because the converting Holder requested that shares of Common
Stock be issued in a name other than its own, such Holder will pay such tax and the Conversion Agent, until having received a sum sufficient to pay such tax, may refuse to deliver any certificates representing the shares of Common Stock being issued
in a name other than that of such Holder. 
 (f) Notices. Whenever a Conversion Date occurs with respect to a Note, the
Conversion Agent will, as promptly as possible, and in no event later than the Business Day immediately following such Conversion Date, deliver to the Company and the Trustee notice that a Conversion Date has occurred, which notice will state such
Conversion Date, the principal amount of Notes converted on such Conversion Date and the names of the Holders that converted Notes on such Conversion Date. 

  
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 Section 10.03 Conversion Obligation. 

(a) Conversion Obligation. Except as set forth in Sections 10.07 and 10.08 hereof, if a Holder surrenders all
or a portion of a Note for conversion, the Company will deliver to such Holder, on the third Business Day immediately following the Conversion Date for such Note, (i) a number of shares of Common Stock equal to the product of (A)(x) the
aggregate principal amount of such Note to be converted divided by (y) $1,000 and (B) the Conversion Rate in effect on such Conversion Date, rounded down to the nearest whole number, and (ii) an amount of cash
equal to the product of (A) the fraction of a share of Common Stock eliminated by such rounding and (B) the Last Reported Sale Price of the Common Stock on such Conversion Date (or if such Conversion Date is not a Trading Day, the
immediately preceding Trading Day). 
 (b) Conversion of Multiple Notes by a Single Holder. If a Holder converts
more than one Note on a single Conversion Date, the number of shares of Common Stock that the Company will deliver to the converting Holder, and the amount of cash that the Company will pay to such Holder in lieu of fractional shares of Common
Stock, will be computed based on the total principal amount of Notes converted on such Conversion Date by such Holder. 
 (c)
Settlement of Accrued Interest and Deemed Payment of Principal. If a Holder converts a Note, the Company will not make any separate cash payment or adjust the Conversion Rate to account for any accrued and unpaid interest on the Note, and the
Company’s delivery of the number of shares of Common Stock and the amount of cash, if any, into which a Note is convertible will be deemed to satisfy and discharge in full the Company’s obligation to pay the principal of such Note and
accrued and unpaid interest, if any, on, such Note to, but excluding the Conversion Date; provided, however, that if a Holder converts a Note after a Regular Record Date and prior to the Open of Business on the corresponding Interest
Payment Date, the Company will still be obligated to pay the interest due on such Interest Payment Date to the Holder of such Note as of the Close of Business on such Regular Record Date 

As a result, except as otherwise provided in the proviso to the immediately preceding sentence, any accrued and unpaid interest with
respect to a converted Note will be deemed to be paid in full rather than cancelled, extinguished or forfeited. In addition, if both cash and shares of the Common Stock are delivered upon the conversion of a Note, accrued and unpaid interest will be
deemed to be paid first out of the amount of cash so delivered. 
 Section 10.04 Common Stock Issued Upon
Conversion. 
 (a) Prior to issuing of any shares of Common Stock under this Article 10, and from time to time thereafter as
may be necessary, the Company will reserve out of its authorized but unissued shares of Common Stock a number of shares of Common Stock sufficient to permit the conversion of the Notes. 

(b) Any shares of Common Stock delivered upon the conversion of the Notes will be newly issued shares or treasury shares, duly and
validly issued, fully paid, nonassessable, free from preemptive rights and free of any lien or adverse claim (except to the extent of any lien or adverse claim created by the action or inaction of the Holder or other Person to whom such shares of
Common Stock will be delivered). In addition, the Company will endeavor to comply 

  
 65 

 
promptly with all federal and state securities laws regulating the offer and delivery of any shares of Common Stock issuable upon conversion of the Notes; provided that the Company will
not be obligated to register the offer and sale of such Common Stock under the Securities Act or any other applicable securities laws. The Company will also use commercially reasonable efforts to cause any shares of Common Stock issuable upon
conversion of a Note to be listed on whatever stock exchange(s) the Common Stock is listed on the date the converting Holder becomes a record holder of such Common Stock. 
 (c) If any shares of the Common Stock issued upon conversion will, upon delivery as part of the conversion obligation, be “restricted securities” (within the meaning of Rule 144 or any successor
provision in effect at such time), such shares of Common Stock (i) will be issued in physical, certificated form; (ii) will not be held in book-entry form through the facilities of the Depositary; and (iii) will bear any restrictive
legends the Company or the Transfer Agent deem necessary to comply with applicable law. 
 Section 10.05 Adjustment of
Conversion Rate. 
 The Company will adjust the Conversion Rate from time to time as described in this Section 10.05,
except that the Company will not make an adjustment to the Conversion Rate if each Holder participates (other than in the case of a share split or share combination), at the same time and upon the same terms as holders of the Common Stock, and
solely as a result of holding the Notes, in the relevant transaction described in this Section 10.05 without having to convert its Notes as if it held a number of shares of the Common Stock equal to the product of (i) the Conversion Rate
in effect on the applicable record date, Effective Date or expiration date, and (ii) the aggregate principal amount of Notes held by such Holder (express in thousands) on such date, rounded up to the nearest whole number. 

(a) Stock Dividends and Share Splits. If the Company issues shares of Common Stock as a dividend or distribution on shares of the
outstanding Common Stock, or if the Company effects a share split of the Common Stock or a share combination of the Common Stock, the Conversion Rate will be adjusted based on the following formula: 

 
 

 
 Where: 
  

	 	CR0      =	 the Conversion Rate in effect immediately prior to the Close of Business on the record date of such dividend or distribution, or immediately prior to
the Open of Business on the Effective Date of such share split or share combination, as applicable; 

  

	 	CR1      =	 the Conversion Rate in effect immediately after the Close of Business on such record date or the Open of Business on such Effective Date;

  

	 	OS0      =	 the number of shares of Common Stock outstanding immediately prior to the Close of Business on such record date or the Open of Business on such
Effective Date; and 

  
 66 

	 	OS1      =	 the number of shares of Common Stock outstanding immediately after giving effect to such dividend, distribution, share split or share combination.

 The foregoing adjustment to the Conversion Rate under this clause (a) shall become effective immediately after the
Close of Business on the record date for such dividend or distribution or immediately after the Open of Business on the Effective Date of such share split or share combination, as applicable. If any dividend or distribution of the type described in
this Section 10.05(a) is declared, but not so paid or made, the Conversion Rate will be immediately readjusted, effective as of the date that the Board of Directors determines not to pay such dividend or distribution, to the Conversion Rate
that would then be in effect if such dividend or distribution had not been declared or announced. 
 (b) Rights, Options and
Warrants. If the Company issues to all or substantially all holders of its outstanding Common Stock rights, options or warrants entitling such holders for a period of not more than 60 calendar days after the date of such issuance to subscribe
for, or purchase, shares of Common Stock, at a price per share less than the average of the Last Reported Sale Prices of the Common Stock for the 10 consecutive Trading Day period ending on the Trading Day immediately preceding the declaration date
of such issuance, the Conversion Rate will be increased based on the following formula: 
  
 

 
 Where: 
  

	 	CR0      =	 the Conversion Rate in effect immediately prior to the Close of Business on the record date for such issuance; 

 

	 	CR1      =	 the Conversion Rate in effect immediately after the Close of Business on such record date; 

 

	 	OS0      =	 the number of shares of Common Stock outstanding immediately prior to the Close of Business on such record date; 

 

	 	X      =	the total number of shares of Common Stock issuable pursuant to such rights, options or warrants; and 

 

	 	Y      =	the number of shares of Common Stock equal to the quotient of (i) the aggregate price payable to exercise such rights, options or warrants, divided by
(ii) the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day period ending on the Trading Day immediately preceding the declaration date of the issuance of such rights, options or warrants.

 Any increase made under this Section 10.05(b) will be made successively whenever any such rights, options or warrants are
issued and shall become effective immediately after the Close of 

  
 67 

 
Business on the record date for such issuance. To the extent that shares of Common Stock are not delivered after the expiration of such rights, options or warrants, including because the issued
rights, options or warrants were not exercised, the Conversion Rate will be immediately decreased to the Conversion Rate that would then be in effect had the increase with respect to the issuance of such rights, options or warrants been made on the
basis of delivery of only the number of shares of Common Stock actually delivered. If such rights, options or warrants are not so issued, the Conversion Rate will be immediately decreased to the Conversion Rate that would then be in effect if the
record date for such issuance had not occurred. 
 For purposes of this Section 10.05(b), in determining whether any
rights, options or warrants entitle holders of the Common Stock to subscribe for, or purchase, shares of Common Stock at a price less per share than the average of the Last Reported Sale Prices of Common Stock for the 10 consecutive Trading Day
period ending on the Trading Day immediately preceding the date of announcement for an issuance, and in determining the aggregate offering price of such shares of Common Stock, there will be taken into account any consideration received by the
Company for such rights, options or warrants and any amount payable on exercise thereof, the value of such consideration, if other than cash, to be determined by the Board of Directors. 

(c) Spin-Offs and Other Distributed Property. 
 (i) If the Company distributes shares of its Capital Stock, evidences of its indebtedness or other assets or property of the Company, or rights, options or warrants to acquire Capital Stock of the Company
or other securities, to all or substantially all holders of the Common Stock, excluding: 
 (A) dividends,
distributions, rights, options or warrants as to which an adjustment was effected pursuant to Section 10.05(a) hereof or Section 10.05(b) hereof, as applicable; 

(B) dividends or distributions paid exclusively in cash for which an adjustment was effected pursuant to
Section 10.05(d) hereof; 
 (C) Spin-Offs for which the provisions set forth in Section 10.04(c)(ii)
hereof will apply; and 
 (D) except as otherwise described below pursuant to which an adjustment is made to the
Conversion Rate pursuant to this clause (c), rights issued pursuant to any Company shareholder rights plan then in effect, 
 then the
Conversion Rate will be increased based on the following formula: 
  
 

 

  
 68 

 Where: 
  

	 	CR0      =	 the Conversion Rate in effect immediately prior to the Close of Business on the record date for such distribution; 

 

	 	CR1      =	 the Conversion Rate in effect immediately after the Close of Business on such record date; 

 

	 	SP0      =	 the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day period ending on the Trading Day immediately
preceding the Ex-Dividend Date for such distribution; and 

  

	 	FMV      =	the fair market value (as determined by the Company’s Board of Directors) of the shares of Capital Stock, evidences of indebtedness, assets, property or rights,
options or warrants to acquire the Company’s Capital Stock or other securities distributed with respect to each outstanding share of Common Stock on the Ex-Dividend Date for such distribution. 

Notwithstanding the foregoing, if “FMV” (as defined above) is equal to or greater than the “SP0” (as defined above), in lieu of the foregoing increase, each Holder
will receive, for each $1,000 principal amount of Notes held on the record date for the distribution, at the same time and upon the same terms as holders of the Common Stock, the amount and kind of shares of Capital Stock, evidences of indebtedness,
assets or property, rights, options or warrants to acquire Capital Stock or other securities that such Holder would have received if such Holder had owned a number of shares of Common Stock equal to the Conversion Rate in effect on the record date
for such distribution. 
 The foregoing increase made in the Conversion Rate under the portion of this clause (c) above
will become effective immediately after the Close of Business on the record date for such distribution. If such distribution is not so paid or made, or if any rights, options or warrants are not exercised before their expiration date, the Conversion
Rate will be immediately decreased to be the Conversion Rate that would then be in effect if such dividend or distribution had not been declared. 
 (ii) With respect to an adjustment pursuant to this Section 10.05(c) where there has been a payment of a dividend or other distribution on the Common Stock of shares of Capital Stock of any class or
series, or similar equity interest, of or relating to a Subsidiary or other business unit of the Company, and such Capital Stock or similar equity interest is listed or quoted (or will be listed or quoted upon the consummation of the transaction) on
a U.S. national securities exchange (a “Spin-Off”), the Conversion Rate will be increased based on the following formula: 
  

 

  
 69 

 Where: 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the last Trading Day of the Valuation Period for such Spin-Off;
			
	CR1	  	=	  	the Conversion Rate in effect immediately after the Close of Business on the last Trading Day of the Valuation Period for such Spin-Off;
			
	FMV0	  	=	  	the average of the Last Reported Sale Prices of the Capital Stock or similar equity interest distributed to holders of the Common Stock applicable to one share of Common Stock
over the first 10 consecutive Trading Day period after, and including, the effective date of the Spin-Off (the “Valuation Period”); and
			
	MP0	  	=	  	the average of the Last Reported Sale Prices of the Common Stock over the Valuation Period.

 If, however, the Conversion Date for a Note occurs after the record date for a
Spin-Off, but on or prior to the first Trading Day of the Valuation Period for such Spin-off, the Conversion Date will be postponed until the Business Day immediately following such Trading Day (and the definition of “FMV0” will be modified pursuant to the immediately following proviso);
and provided, further, that if the Conversion Date for a Note occurs after the first Trading Day of the Valuation Period for a Spin-Off, but on or before the last Trading Day of such Valuation Period, the reference in the above
definition of “FMV0” to “10” will be
deemed replaced with such lesser number of Trading Days as have elapsed from, and including, the effective date of such Spin-Off to, but excluding, such Conversion Date. 
 (d) Cash Dividends or Distributions. If any cash dividend or distribution is made to all or substantially all holders of the outstanding Common Stock, the Conversion Rate will be increased based on
the following formula: 
  
 

 
 Where: 
  

					
	CR0	 	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the record date for such dividend or distribution;
			
	CR1	 	=	  	the Conversion Rate in effect immediately after the Close of Business on the record date for such dividend or distribution;
			
	SP0	 	=	  	the Last Reported Sale Price of the Common Stock on the Trading Day immediately preceding the Ex-Dividend Date for such dividend or distribution; and

  
 70 

					
	 C
	  	 =
	  	 the amount in cash per share the Company distributes to holders of Common Stock.

 Notwithstanding the foregoing, if “C” (as defined above) is equal to or
greater than “SP0” (as defined above), in lieu of
the foregoing increase, each Holder will receive, for each $1,000 principal amount of Notes held on the record date for such cash dividend or distribution, at the same time and upon the same terms as holders of shares of the Common Stock, the amount
of cash that such Holder would have received if such Holder had owned a number of shares of Common Stock equal to the Conversion Rate in effect on such record date. The foregoing increase in the Conversion Rate made under this clause (d) shall
become effective immediately after the Close of Business on the record date for such dividend or distribution. If any such dividend or distribution of the type described in this clause (d) is declared but not so paid or made, the Conversion
Rate will be immediately decreased, effective as of the date that the Board of Directors determines not to make or pay such dividend or distribution, to the Conversion Rate that would then be in effect if such dividend or distribution had not been
declared. 
 (e) Tender Offers or Exchange Offers. If the Company or any of the Subsidiaries makes a payment in respect
of a tender offer or exchange offer for the Common Stock (other than an odd lot tender offer), to the extent that the cash and value of any other consideration included in the payment per share of Common Stock exceeds the Last Reported Sale Price of
the Common Stock on the Trading Day next succeeding the last date on which tenders or exchanges may be made pursuant to such tender offer or exchange offer (such last date, the “Expiration Date”), the Conversion Rate will be
increased based on the following formula: 
  
 

 
 Where: 
  

					
	CR0	  	=	  	the Conversion Rate in effect immediately prior to the Close of Business on the 10th Trading Day immediately following, and including, the Trading Day next succeeding the
Expiration Date;
			
	CR1	  	=	  	the Conversion Rate in effect immediately after the Close of Business on the 10th Trading Day immediately following, and including, the Trading Day next succeeding the Expiration
date;
			
	AC	  	=	  	the aggregate value of all cash and any other consideration (as determined by the Board of Directors) paid or payable for shares purchased in such tender or exchange
offer;
			
	OS0	  	=	  	the number of shares of Common Stock outstanding immediately prior to the expiration time on the Expiration Date (prior to giving effect to the purchase of all shares accepted
for purchase or exchange in such tender or exchange offer);

  
 71 

					
	OS1	  	=	  	the number of shares of Common Stock outstanding immediately after the expiration time on the Expiration Date (after giving effect to the purchase of all shares accepted for
purchase or exchange in such tender or exchange offer); and
			
	SP1	  	=	  	the average of the Last Reported Sale Prices of the Common Stock over the 10 consecutive Trading Day period commencing on the Trading Day next succeeding the Expiration
Date.

 If, however, the Conversion Date for a Note occurs after the first Trading Day during
the 10 Trading Days immediately following, and including, the Trading Day next succeeding the Expiration Date, but on or prior to the last Trading Day of such period, the reference in the above definition of “SP1” to “10” and the references in the above definitions of
“CR0” and “CR1” to
“10th” will be deemed replaced with references
to such lesser number of Trading Days as have elapsed from, and including, the Trading Day next succeeding the Expiration Date to, but excluding such Conversion Date. 
 (f) Successive Adjustments. After an adjustment to the Conversion Rate under this Article 10, any subsequent event requiring an adjustment under this Article 10 will cause an adjustment to the
Conversion Rate as so adjusted, without duplication. 
 (g) Adjustments Not Yet Effective. If a Holder converts a Note
and, as of the Conversion Date for such Note, any distribution or transaction that requires an adjustment to the Conversion Rate pursuant to Sections 10.05(a) through (e) hereof has occurred but has not yet resulted in an adjustment to the
applicable Conversion Rate on the Conversion Date and the shares of Common Stock that such Holder will receive upon settlement of its converted Note are not entitled to participate in the relevant distribution or transaction (because they were not
held on a related record date or otherwise), then the Company will adjust the number of shares of Common Stock that it delivers to such Holder to reflect the relevant distribution or transaction. 

(h) Shareholder Rights Plans. To the extent that the Company’s rights plan is in effect when a Holder converts a Note, the
Company will deliver to such Holder, in addition to each share of Common Stock otherwise issuable to such Holder upon conversion of such Note, any rights that, under the rights plan, would be applicable to a share of Common Stock, unless prior to
the Conversion Date for such Note, the rights have separated from the Common Stock, in which case, and only in such case, the Conversion Rate will be adjusted pursuant to Section 10.05(c)(i) as if, at the time of such separation, the Company
had distributed to all holders of the Common Stock shares of its Capital Stock, evidences of its indebtedness, other assets or property of the Company or rights, options or warrants to acquire its Capital Stock or other securities as described in
Section 10.05(c), subject to readjustment in the event of the expiration, termination or redemption of such rights. 
 (i)
Other Adjustments. Whenever any provision of this Indenture requires the calculation of the Last Reported Sale Price or a function thereof over a span of multiple days, the Company will make appropriate adjustments to the Last Reported Sale
Price or such function thereof to account for any adjustment to the Conversion Rate that becomes effective, or any event requiring an adjustment to the Conversion Rate where the Ex-Dividend date, Effective

  
 72 

 
Date or expiration date of the event occurs at any time during the period when the Last Reported Sale Prices or functions thereof are to be calculated. 

(j) Restrictions on Adjustments. Except as a result of (i) a reverse share split, share combination, or readjustment
resulting from dividends or distributions having been declared but not paid or made, (ii) readjustments resulting from distributed rights, options or warrants to the extent that shares of Common Stock have not been delivered after the
expiration of such rights, including because the issued rights, options or warrants were not exercised and readjustments where rights options or warrants were not issued, (iii) readjustments resulting from the distribution of Capital Stock,
evidences of the Company’s indebtedness or other assets or property of the Company having been declared but not paid, (iv) readjustments resulting from distributions or deemed distributions of contingent rights, options or warrants that
were redeemed or repurchased without being exercised prior to their expiration or termination and (v) readjustment from cash dividends or distributions having been declared but not paid or made and, in no event will the Conversion Rate be
immediately adjusted downward pursuant to Sections 10.05(a), (b), (c), (d) or (e) hereof. 
 In addition,
notwithstanding anything to the contrary elsewhere in this Indenture, the Conversion Rate will not be adjusted: 
 (i) upon the
issuance of any shares of Common Stock pursuant to any present or future plan providing for the reinvestment of dividends or interest payable on the Company’s securities and the investment of additional optional amounts in shares of Common
Stock under any plan; 
 (ii) upon the issuance of any shares of Common Stock or options or rights to purchase those shares
pursuant to any present or future employee, director or consultant benefit plan or program of, or assumed by, the Company or any of the Subsidiaries; 
 (iii) upon the issuance of any shares of Common Stock pursuant to any option, warrant, right or exercisable, exchangeable or convertible security not described in the preceding clause and outstanding as
of the date of the Issue Date; 
 (iv) for a change in the par value of the Common Stock; or 

(v) for accrued and unpaid interest. 
 (k) Deferral of Adjustments. The Company may defer any adjustment to the Conversion Rate unless such adjustment would increase the Conversion Rate by at least 1% of the Conversion Rate in effect at
the time the Company would otherwise be required to make such adjustment; provided, however, that if the Company defers an adjustment pursuant to this Section 10.05(k), then the Company must carry forward such adjustment and take
it into account in any future adjustment. Notwithstanding the foregoing, (i) upon the Conversion Date for any Note and (ii) on each annual anniversary of the Issue Date, the Company will give effect to all adjustments that it has otherwise
been deferred pursuant to this Section 10.05(k), and those adjustments will no longer be carried forward and taken into account in any future adjustment. 
 (l) Miscellaneous. 

  
 73 

 (i) Certain Definitions.  

(A) For purposes of this Section 10.05, (1) the number of shares outstanding at any time will include shares issuable in
respect of scrip certificates issued in lieu of fractions of shares of Common Stock, but, (2) so long as the Company does not pay any dividend or make any distribution on shares of Common Stock held in the treasury of the Company, will not
include shares of Common Stock held in the treasury of the Company. 
 (B) For purposes of this Section 10.05, the term
“Effective Date” will mean the first date on which the Common Stock trades on the applicable exchange or in the applicable market, regular way, reflecting the transaction. 

(C) For purposes of this Section 10.05, the term “Ex-Dividend Date” will mean the first date on which the shares
of the Common Stock trade on the applicable exchange or in the applicable market, regular way, without the right to receive the issuance, dividend or distribution in question. 
 Section 10.06 Voluntary Adjustments. 
 (a) Best Interest
Increases. Subject to the limitations of Section 10.06(d) hereof, the Company may, from time to time, to the extent permitted by law, increase the Conversion Rate by any amount if (i) the Board of Directors determines that such
increase is in the best interest of the Company, (ii) such increase is in effect for a period of at least 20 Business Days, and (iii) during such period, such increase is irrevocable. 

(b) Tax-Related Increases. Subject to the limitations of Section 10.06(d) hereof and to the extent permitted by law, the
Company may (but is not required to) increase the Conversion Rate if the Board of Directors determines that such increase is advisable to avoid, or diminish, any income tax imposed on holders of the Common Stock or rights to purchase the Common
Stock as a result of any dividend or distribution of shares (or rights to acquire shares) or similar event treated as such for U.S. federal income tax purposes. 
 (c) Notices. Whenever the Board of Directors determines that the Company will increase the Conversion Rate pursuant to this Section 10.06, the Company will send to each Holder notice of such
increase at least 15 Business Days before such increase will take effect, which notice will state the increase to be made and the period during which such increase will be in effect. 

(d) Voluntary Actions. The Company will not take any voluntary action that would result in an adjustment to the Conversion Rate
pursuant to Sections 10.05, 10.06 and 10.07 without complying, if applicable, with the stockholder approval rules of The NASDAQ Global Select Market or any similar rule of any stock exchange on which the Common Stock is listed at the relevant time.
In accordance with such listing standards, this restriction will apply at any time when the Notes are outstanding, regardless of whether the Company then have a class of securities listed on The NASDAQ Global Select Market. 

  
 74 

 Section 10.07 Adjustments Upon Certain Fundamental Changes. 

(a) General. If (i) a Fundamental Change (determined after giving effect to the paragraph immediately
following clause (v) of the definition thereof, but without regard to the exclusion in clause (ii)(B) of the definition thereof) occurs or (ii) the Company calls the Notes for redemption pursuant to Article 11 (either such event, a
“Make-Whole Fundamental Change”), and a Holder elects to convert its Notes in connection with such Make-Whole Fundamental Change, the Company will, in the circumstances described in this Section 10.07, increase the Conversion
Rate for such Notes by the number of additional shares of Common Stock (the “Additional Shares”) described in this Section 10.07. For purposes of this Section 10.07, a conversion of Notes will be deemed to be “in
connection with”:  
 (i) a Make-Whole Fundamental Change described in clause (i) of the definition of
“Make-Whole Fundamental Change” if the Conversion Notice for such Notes is received by the Conversion Agent during the period beginning on, and including, the Make-Whole Fundamental Change Effective Date for such Make-Whole Fundamental
Change and ending on, and including, (A) if such Make-Whole Fundamental Change is also a Fundamental Change, the later of (x) the Close of Business on the third Business Day immediately prior to the related Fundamental Change Repurchase
Date and (y) the Close of Business on the 30th Business Day immediately following the date the Company delivers notice to each Holder of such Make-Whole Fundamental Change pursuant to this Section 10.07, and (B) if such Make-Whole
Fundamental Change is not a Fundamental Change, the Close of Business on the 30th Business Day immediately following the date the Company delivers notice to each Holder of such Make-Whole Fundamental Change pursuant to this Section 10.07; and

 (ii) a Make-Whole Fundamental Change described in clause (ii) of the definition of “Make-Whole Fundamental
Change” if the Conversion Notice for such Notes is received by the Conversion Agent during the period beginning on, and including, the Make-Whole Fundamental Change Effective Date for such Make-Whole Fundamental Change and ending on the Close
of Business on the third Business Day immediately preceding the relevant Redemption Date. 
 No later than 5 Business Days after
the effective date of a Make-Whole Fundamental Change described in clause (i) of the definition of Make-Whole Fundamental Change contained in this Section 10.07, the Company will notify the Holders of such effective date and issue a press
release announcing such effective date. 
 (b) Determination of Additional Shares. The number of Additional Shares by
which the Conversion Rate will be increased if a Holder converts a Note in connection with a Make-Whole Fundamental Change will be determined by reference to the table below, and will be based on the Make-Whole Fundamental Change Effective Date and
the Stock Price for such Make-Whole Fundamental Change. For any Make-Whole Fundamental Change, the “Make-Whole Fundamental Change Effective Date” will mean, (i) if such Make-Whole Fundamental Change is of the type described in
clause (i) of the definition of Make-Whole Fundamental Change contained in Section 10.07(a) hereof, the effective date of such Make-Whole Fundamental Change, and (ii) if such Make-Whole Fundamental Change is of the type described

  
 75 

 
in clause (ii) of the definition of Make-Whole Fundamental Change contained in Section 10.07(a) hereof, the applicable Redemption Notice Date. 

(c) Adjustment of Stock Prices and Additional Shares. The Stock Prices set forth in the first row (i.e., the column
headers) of the table below will be adjusted on each date on which the Conversion Rate must be adjusted pursuant to Section 10.05. The adjusted Stock Prices will equal the Stock Prices in effect immediately prior to such adjustment, multiplied
by a fraction, (i) the numerator of which is the Conversion Rate in effect immediately prior to the adjustment giving rise to the Stock Price adjustment, and (ii) the denominator of which is the Conversion Rate in effect immediately after
the adjustment. The numbers of Additional Shares set forth in the table below will be adjusted in the same manner, at the same time and for the same events for which the Conversion Rate is adjusted pursuant to Section 10.05 hereof. 

(d) Additional Shares Table. The following table sets forth hypothetical Make-Whole Fundamental Change Effective Dates, Stock
Prices and the number of Additional Shares by which the Conversion Rate will be increased per $1,000 principal amount of Notes for a Holder that converts a Note in connection with a Make-Whole Fundamental Change having such Make-Whole Fundamental
Change Effective Date and Stock Price. 
  

																																											
	 	  	Stock Price	 
	 Effective Date
	  	$3.63	 	  	$4.15	 	  	$4.63	 	  	$5.50	 	  	$6.48	 	  	$8.00	 	  	$10.00	 	  	$14.00	 	  	$18.00	 	  	$22.00	 
	 September 17, 2012
	  	 	59.4177	  	  	 	44.8510	  	  	 	36.2970	  	  	 	26.8080	  	  	 	20.4780	  	  	 	14.3780	  	  	 	9.3940	  	  	 	3.9400	  	  	 	1.3470	  	  	 	0.2190	  
	 October 1, 2013
	  	 	59.4177	  	  	 	40.7840	  	  	 	32.0530	  	  	 	23.0500	  	  	 	17.5000	  	  	 	12.3540	  	  	 	8.1710	  	  	 	3.5250	  	  	 	1.2370	  	  	 	0.2050	  
	 October 1, 2014
	  	 	59.4177	  	  	 	35.1140	  	  	 	26.3420	  	  	 	18.1810	  	  	 	13.6950	  	  	 	9.7170	  	  	 	6.4840	  	  	 	2.8450	  	  	 	0.9960	  	  	 	0.1470	  
	 October 1, 2015
	  	 	59.4177	  	  	 	29.8470	  	  	 	20.3710	  	  	 	12.8910	  	  	 	9.5840	  	  	 	6.8540	  	  	 	4.6240	  	  	 	2.0880	  	  	 	0.7450	  	  	 	0.0890	  
	 October 1, 2016
	  	 	59.4177	  	  	 	24.9030	  	  	 	13.4050	  	  	 	6.7560	  	  	 	4.9880	  	  	 	3.6170	  	  	 	2.4690	  	  	 	1.1570	  	  	 	0.4340	  	  	 	0.0380	  
	 October 1, 2017
	  	 	59.4177	  	  	 	24.8990	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  	  	 	0.0000	  

 (e) Use of Additional Shares Table. If the Stock Price and/or Make-Whole Fundamental Change
Effective Date for a Make-Whole Fundamental Change are not set forth in the table above, then: 
  

	 	(3)	if the Stock Price is between two Stock Prices in the table or the Make-Whole Fundamental Change Effective Date is between two Make-Whole Fundamental Change Effective
Dates in the table, the number of Additional Shares by which the Conversion Rate will be increased for a Holder that converts a Note in connection with such Make-Whole Fundamental Change will be determined by a straight-line interpolation between
the number of Additional Shares set forth for the higher and lower Stock Prices listed in the table and the earlier and later Make-Whole Fundamental Change Effective Dates listed in the table, as applicable, based on a 365-day year;

  

	 	(4)	if the Stock Price is greater than $22.00, subject to adjustment in the same manner as the Stock Prices set forth in the column headings of the table, no Additional
Shares will be added to the Conversion Rate; and 

  
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	 	(5)	if the Stock Price is less than $3.63, subject to adjustment in the same manner as the Stock Prices set forth in the column headings of the table, no Additional Shares
will be added to the Conversion Rate. 

 Notwithstanding the foregoing, in no event will the Conversion Rate be increased as a
result of this Section 10.07 to exceed 275.4821 shares of Common Stock per $1,000 principal amount of Notes, subject to adjustment in the same manner, at the same time and for the same events for which the Conversion Rate must be adjusted as
set forth in Section 10.05 hereof. 
 (f) Settlement or Conversion. Except as provided in Section 10.08 hereof,
if a Holder converts a Note in connection with a Make-Whole Fundamental Change, the Company will settle such conversion by delivering a number of shares of Common Stock and an amount of cash in lieu of fractional shares of Common Stock in accordance
with Section 10.03 hereof; provided, however, that notwithstanding anything to the contrary in Section 10.03 hereof, if a Holder converts a Note in connection with a Make-Whole Fundamental Change described in clause
(ii) of the definition of Fundamental Change in which the holders of the Common Stock receive only cash in consideration for their shares of Common Stock, the Company will settle such conversion by delivering to such Holder, on the third
Business Day immediately following the Conversion Date for such Note, an amount of cash, for each $1,000 principal amount of such Note converted, equal to the product of (i) the Conversion Rate on the Conversion Date applicable to such Note
(including any Additional Shares added to such Conversion Rate pursuant to this Section 10.07) and (ii) the Stock Price for such Make-Whole Fundamental Change. 
 Section 10.08 Effect of Recapitalization, Reclassification, Consolidation, Merger or Sale. 
 (a) General. If any of the following events occur: 
 (1) any
recapitalization, reclassification or change of the Common Stock (other than changes resulting from a subdivision or combination or change only in par value or from par value to no par value or no par value to par value); 

(2) any consolidation, merger or combination involving the Company; 

(3) any sale, lease or other transfer to a third party of the consolidated assets of the Company and the Subsidiaries substantially as an
entirety; or 
 (4) any statutory share exchange; 
 and, in each case, as a result of which the Common Stock would be converted into, or exchanged for, Capital Stock, other securities, other property or assets (including cash or any combination thereof)
(each such event, a “Merger Event,” and, for any Merger Event, the “Reference Property” for such Merger Event), then, at the effective date of such Merger Event, the Company and the resulting, surviving or
transferee Person (if other than the Company) of such Merger Event (the “Merger Successor Corporation”) will execute and deliver to the Trustee a supplemental indenture pursuant to Section 9.03 hereof, which supplemental
indenture will provide that the right to convert each $1,000 principal amount of Notes into shares of Common 

  
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Stock and cash in lieu of fractional shares of Common Stock will be changed into the right to convert each $1,000 principal amount of Notes into a number of Units of Reference Property initially
equal to the Conversion Rate in effect prior to the effective time of the Merger Event and an amount of cash in lieu of any fractional Unit of Reference Property equal to the product of (A) such fractional Unit of Reference Property and
(B) the Last Reported Sale Price of a Unit of Reference Property on the applicable Conversion Date. In addition: 
 (A)
each reference to the “Last Reported Sale Price of the Common Stock” will be deemed to be replaced by a reference to the “Last Reported Sale Price of a Unit of Reference Property;” 

(B) if a Unit of Reference Property does not consist solely of one type of common stock that is listed on a U.S. national or regional
securities exchange, the adjustments to the Conversion Rate provided in Section 10.05 hereof will be modified as determined by the Board of Directors to provide the Holders with adjustments that have an economic effect on the Holders as nearly
equivalent as practicable to the economic effect the adjustments provided by Section 10.05 hereof would have had on the Holders but for such Merger Event. 
 As promptly as practicable after executing a supplemental indenture in accordance with Section 10.08(a) hereof, the Company will (i) file with the Trustee an Officer’s Certificate briefly
describing the reasons therefor, the composition of a Unit of Reference Property for such Merger Event, any adjustment to be made with respect thereto and that all conditions precedent under this Indenture to such Merger Event have been complied
with; and (ii) cause to be sent to each Holder, at the address of such Holder as it appears in the register of the Notes maintained by the Registrar, a notice of the execution of such supplemental indenture and the composition of a Unit of
Reference Property for such Merger Event; provided, that the failure to deliver such notice to any Holder will not affect the validity or legality of such supplemental indenture. 

(b) Successive Merger Events. If more than one Merger Event occurs, this Section 10.08 will apply successively to each Merger
Event. 
 (c) Compliance Covenant. The Company will not become a party to any Merger Event unless its terms are
consistent with this Section 10.08. 
 Section 10.09 

Section 10.10 Notice to Holders Prior to Certain Actions. 

(a) In case of any Merger Event then the Company shall cause to be filed with the Trustee and the Conversion Agent (if other than the
Trustee) and to be sent to each Holder at its address appearing on the Register, as promptly as possible but in any event at least 10 days prior to the applicable date hereinafter specified, a notice stating (i) the date on which a record is to
be taken for the purpose of such action by the Company or one of the Subsidiaries or, if a record is not to be taken, the date as of which the holders of Common Stock of record are to be determined for the purposes of such action by the Issuer or
one of the Subsidiaries, (ii) the date on which such Merger Event is expected to become effective or occur, (iii) the Conversion Rate in effect as of the date the Company delivers such notice, (iv) the composition of a Unit of
Reference Property for such Merger Event and (v) , if applicable, the date as of which it is expected that 

  
 78 

 
holders of Common Stock of record shall be entitled to exchange their Common Stock for securities or other property deliverable upon such Merger Event. Failure to give such notice, or any defect
therein, shall not affect the legality or validity of such action by the Company or one of the Subsidiaries. 
 (b) Whenever the
Company adjusts the Conversion Rate pursuant to Section 10.05, the Company will promptly deliver to each Holder a written notice, which notice will include (i) a brief description of the event requiring adjustment to the Conversion Rate
pursuant to Section 10.05, (ii) the effective date of such adjustment, (iii) the Conversion Rate in effect after such adjustment is made and (iv) a schedule explaining, in reasonable detail, how the Company calculated such
adjustment. On the same day the Company delivers such notice to each Holder, the Company will deliver to the Trustee, the Paying Agent and the Conversion Agent an Officer’s Certificate that includes all of the information contained in such
notice, which Officer’s Certificate each of the Trustee, the Paying Agent and the Conversion Agent may treat as conclusive evidence that the adjustment specified in such Officer’s Certificate is correct and will be in effect as of the
effective date specified in such Officer’s Certificate. The failure to deliver such notice will not affect the legality or validity of any such adjustment. 
 Section 10.11 No Responsibility of Trustee. 
 The Trustee and the
Conversion Agent will not have any duty or responsibility to any Holder to determine whether any facts exist that require an adjustment of the Conversion Rate, or with respect to the nature or extent or calculation of any such adjustment when made,
or with respect to the method employed in making the same. Neither the Trustee nor the Conversion Agent will be responsible for any failure of the Company to deliver the number of shares of Common Stock and any amount of cash in lieu of fractional
shares of the Common Stock due upon the surrender of any Notes for the purpose of conversion or to comply with any of the duties, responsibilities or covenants of the Company contained in this Article 10. Without limiting the generality of the
foregoing, neither the Trustee nor the Conversion Agent will be under any responsibility to determine the correctness of any provisions contained in any supplemental indenture entered into pursuant to Section 10.08 hereof, including with
respect to the calculation of the amount of cash and the number of Units of Reference Property, if any, receivable by Holders upon the conversion of their Notes after any Merger Event, and each, subject to the provisions of Article 6, may accept as
conclusive evidence of the correctness of any such provisions, and will be protected in relying upon, the Officer’s Certificate (which the Company will be obligated to file with the Trustee prior to the execution of any such supplemental
indenture) with respect thereto. 
 ARTICLE 11 
 REDEMPTION AT THE OPTION OF THE COMPANY 
 Section 11.01 No Sinking
Fund. No sinking fund is provided for the Notes. 
 Section 11.02 Right To Redeem the Notes. 

(a) General. Prior to October 1, 2015, the Company may not redeem the Notes. On or after October 1, 2015, and prior to
the Maturity Date, the Company may redeem all, but not 

  
 79 

 
less than all, of the Notes on the Redemption Date for an amount of cash equal to the Redemption Price if the Last Reported Sale Price of the Common Stock equals or exceeds 140% of the Conversion
Price in effect on each of at least 20 Trading Days during the 30 consecutive Trading Day period ending on the Trading Day immediately preceding the date on which the Company delivers the Redemption Notice for such redemption pursuant to
Section 11.02 hereof. 
 (b) The “Redemption Price” means, for any Notes to be redeemed on a Redemption
Date, a price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest, if any, on such Notes to, but excluding, such Redemption Date; provided, however, that if a Redemption Date occurs after
a Regular Record Date, but on or prior to the Interest Payment Date corresponding to such Regular Record Date, the Redemption Price for any Notes to be redeemed will equal 100% of the principal amount of such Notes and accrued and unpaid interest,
if any, on such Notes will be payable to the Holder of such Notes at the Close of Business on such Regular Record Date. 
 (c)
The “Redemption Date” means, for any redemption, the date specified as such on the Redemption Notice for such redemption, which date must be a Business Day and must be not less than 30 calendar days, nor more than 60 calendar days,
immediately following the date on which the Company delivers such Redemption Notice. 
 Section 11.03 Redemption
Notice. 
 At least 30 calendar days but not more than 60 calendar days prior to any Redemption Date, the Company will deliver to
each Holder (and to any beneficial owner of a Global Note, as required by applicable law) a written notice of redemption (the “Redemption Notice,” and the date of such mailing or delivery, the “Redemption Notice
Date”) and, substantially contemporaneously therewith, the Company will issue a press release announcing such redemption. If the Company desires to instruct the Trustee to deliver the Redemption Notice, the Company will give the Trustee at
least 15 days’ written notice of such instruction prior to the Redemption Date (unless a shorter time period is agreed to by the Trustee). 
 For any redemption, the Redemption Notice corresponding to such redemption will specify: 
  

	 	(1)	the Redemption Price for such Redemption Date (for each $1,000 principal amount of Notes); 

 

	 	(2)	the Redemption Date for such redemption; 

  

	 	(3)	the name and address of the Paying Agent and of the Conversion Agent; 

  

	 	(4)	that Notes called for redemption may be converted at any time before the Close of Business on the third Business Day immediately preceding the Redemption Date;

  
 80 

	 	(5)	the Conversion Rate in effect on the Redemption Notice Date for such redemption and the Last Reported Sale Price of the Common Stock on the Trading Day immediately
preceding the Redemption Notice Date; 

  

	 	(6)	any Additional Shares by which the Conversion Rate will be increased pursuant to Section 10.07 hereof for a Holder that converts a Note “in connection
with” the Company’s election to redeem the Notes; 

  

	 	(7)	that Notes must be surrendered to the Paying Agent on or before the Redemption Date to collect the Redemption Price; 

 

	 	(8)	that, unless the Company defaults in paying the Redemption Price on the Redemption Date, interest, if any, on a Note will cease to accrue on and after the Redemption
Date; and 

  

	 	(9)	the CUSIP and ISIN number(s) of the Notes. 

 On any Redemption Notice Date, the Company will also furnish to the Trustee an Officer’s Certificate, which Officer’s Certificate will set forth the aggregate principal amount of Notes then
outstanding and include a copy of the Redemption Notice delivered by the Company on such Redemption Notice Date. 

Section 11.04 Effect of Redemption Notice. 
 After the Company has delivered a Redemption Notice, each Holder will have the right to receive payment of the Redemption Price for its Notes on the Redemption Date (i) if the Notes are Definitive
Notes, by delivering its Notes to the Paying Agent on or before the Close of Business on such Redemption Date, and (ii) if the Notes are Global Notes, by complying with the Applicable Procedures relating to the redemption and delivering the
beneficial interests to be redeemed to the Paying Agent on or before the Close of Business on such Redemption Date; provided, however, that, until the Close of Business on the third Business Day immediately preceding such Redemption
Date, Holders may convert their Notes, regardless of whether they have been delivered to the Paying Agent for redemption, by complying with the requirements for conversion set forth in Article 10. 

Section 11.05 Deposit of Redemption Price. 
 Prior to 11:00 a.m., New York City time, on the Redemption Date, the Company will deposit with the Paying Agent (or, if the Company or a Subsidiary or an Affiliate of either of them is acting as the
Paying Agent, will segregate and hold in trust as provided in Section 2.07 hereof) an amount of immediately available funds sufficient to pay the Redemption Price of all of the then outstanding Notes. 

Section 11.06 Effect of Deposit. 
 If, as of 11:00 a.m., New York City time, on any Redemption Date, the Company, in accordance with Section 11.05 hereof, has deposited with the Paying Agent money sufficient to pay the Redemption
Price for every Note validly delivered in accordance with Section 11.04 

  
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hereof (and not converted before such Redemption Date), then, at the Close of Business on such Redemption Date: 
  

	 	(1)	every Note outstanding immediately prior to the Close of Business on such Redemption Date will cease to be outstanding and interest, if any, on such Notes will cease to
accrue (regardless of whether such Notes were delivered to the Paying Agent or book-entry transfer has been made, as applicable); and 

  

	 	(2)	all other rights of the Holders of such Notes with respect to such Notes (other than the right to receive payment of the Redemption Price or, in the case of Notes
surrendered for conversion in accordance with Article 10 hereof, the right to receive the number of shares of Common Stock and the amount of cash in lieu of fractional share of Common Stock due upon conversion of such Notes) will terminate.

 Section 11.07 Covenant Not to Redeem Notes Upon Certain Events of Default. 

(a) General. Notwithstanding anything to the contrary in this Article 11, the Company will not redeem any Notes under this Article
11 if the principal amount of the Notes has been accelerated and such acceleration has not been rescinded on, or prior to, the Redemption Date (except in the case of an acceleration resulting from a Default by the Company that would be cured by the
Company’s payment of the Redemption Price for such Notes). 
 (b) Return of Notes. If a Holder delivers a Note for
redemption pursuant to Section 11.04 and, on the Redemption Date, pursuant to this Section 11.07, the Company is not permitted to redeem such Note, the Paying Agent will (i) if such Note is a Definitive Note, return such Note to such
Holder, and (ii) if such Note is held in book-entry form, in compliance with the Applicable Procedures, deem to be cancelled any instructions for book-entry transfer of such Note. 

Section 11.08 Repayment to the Company. 
 Subject to any applicable property laws, if, six months after the Redemption Date, any cash held by the Paying Agent remains unclaimed, the Paying Agent will promptly return such cash to the Company;
provided, however, that, to the extent that the aggregate amount of cash deposited by the Company pursuant to Section 11.05 exceeds the aggregate Redemption Price of every Note outstanding, then as soon as practicable following
the Redemption Date, the Trustee will return such excess to the Company. 

  
 82 

 ARTICLE 12 
 MISCELLANEOUS 
 Section 12.01 [Reserved]. 

Section 12.02 Notices. 
 Any request, demand, authorization, notice, waiver, consent or communication will be in writing and delivered in Person or mailed by first-class mail, postage prepaid, addressed as follows or transmitted
by facsimile transmission or other similar means of unsecured electronic methods to the following: 
 if to the Company:

 Sequenom, Inc. 
 3595 John Hopkins Court 
 San Diego, California 92121 

Facsimile: 858-202-9001 
 Attn: Paul Maier 
 if to the Trustee, Registrar, Paying Agent or Conversion Agent:

 Wells Fargo Bank, National Association 
 707 Wilshire Blvd, 17th Floor 
 MAC E2818-176 

Los Angeles, CA 90017 
 Facsimile: 213-614-3355 
 Attn: Sequenom, Inc. Account Manager 

The Company or the Trustee, by notice given to the other in the manner provided above, may designate additional or different addresses
for subsequent notices or communications. 
 Any notice or communication given to a Holder will be sent to the Holder,
electronically in PDF format or, by first class mail, postage prepaid, at the Holder’s address as it appears on the registration books of the Registrar and will be deemed given on the date of such mailing. 

Failure to send a notice or communication to a Holder or any defect in it will not affect its sufficiency with respect to other Holders.
If a notice or communication is sent in the manner provided above, it is duly given, whether or not received by the addressee. 

If the Company sends a notice or communication to the Holders, it will, at the same time, send a copy to the Trustee and each of the
Registrar, Paying Agent and Conversion Agent. 
 If the Company is required under this Indenture to give a notice to the
Holders, in lieu of delivering such notice to the Holders, the Company may deliver such notice to the Trustee and cause the Trustee, at the Company’s expense, to have delivered such notice to the Holders on or prior to the date on which the
Company would otherwise have been required to deliver such 

  
 83 

 
notice to the Holders. In such a case, the Company will also cause the Trustee to send a copy of the notice to each of the Registrar, Paying Agent and Conversion Agent at the same time it sends
the notice to the Holders. 
 Section 12.03 Certificate and Opinion as to Conditions Precedent. 

Upon any request or application by the Company to the Trustee to take any action under this Indenture, the Company will furnish to the
Trustee: 
 (a) an Officer’s Certificate stating that, in the judgment or opinion of the signers, all conditions precedent,
if any, provided for in this Indenture relating to the proposed action have been complied with; and 
 (b) an Opinion of Counsel
stating that, in the judgment or opinion of such counsel, all such conditions precedent relating to the proposed action (to the extent of legal conclusions and subject to reasonable assumptions and exclusions) have been complied with;
provided, that no Opinion of Counsel shall be required to be delivered in connection with the initial issuance of Notes dated as of the date hereof under the Indenture or in connection with the removal of the Restricted Notes Legend on or
after the Free Trade Date. 
 Section 12.04 Statements Required in Certificate or Opinion. 

Each Officer’s Certificate or Opinion of Counsel with respect to compliance with a covenant or condition (except for such
Officer’s Certificate required to be delivered pursuant to Section 4.05 hereof) provided for in this Indenture will include: 
 (a) a statement that each Person making such Officer’s Certificate or Opinion of Counsel has read such covenant or condition; 
 (b) a brief statement as to the nature and scope of the examination or investigation upon which the statements, judgments or opinions contained in such Officer’s Certificate or Opinion of Counsel are
based; 
 (c) a statement that, in the judgment or opinion of each such Person, he has made such examination or investigation as
is necessary to enable such Person to express an informed judgment or opinion to whether or not such covenant or condition has been complied with; and 
 (d) a statement that, in the judgment or opinion of such Person, such covenant or condition has been complied with. 
 Section 12.05 Separability Clause. 
 In case any provision in this
Indenture or in the Notes will be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions will not in any way be affected or impaired thereby. 

  
 84 

 Section 12.06 Rules by Trustee. 

The Trustee may make reasonable rules for action by, or a meeting of, Holders. 

Section 12.07 Governing Law and Waiver of Jury Trial. 

THE INDENTURE AND EACH NOTE WILL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK BUT WITHOUT
REGARD TO CHOICE OF LAWS OR CONFLICTS OF LAWS PROVISIONS THEREOF THAT WOULD REQUIRE THE APPLICATION OF THE LAWS OF ANY OTHER JURISDICTION. EACH OF THE COMPANY AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE
LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTION CONTEMPLATED HEREBY. 
 Section 12.08 No Recourse Against Others. 
 A director, officer,
employee or stockholder, as such, of the Company will not have any liability for any obligations of the Company under the Notes or this Indenture or for any claim based on, in respect of or by reason of such obligations or their creation. By
accepting a Note, each Holder will waive and release all such liability. The waiver and release will be part of the consideration for the issuance of the Notes. 
 Section 12.09 Calculations. 
 Except as otherwise provided in this
Indenture, the Company will be responsible for making all calculations called for under the Notes and this Indenture. These calculations include, but are not limited to, determinations of the Last Reported Sale Price of the Common Stock or any other
security, accrued interest payable on the Notes and the Conversion Rate in effect on any Conversion Date. 
 The Company will
make all calculations in good faith and, absent manifest error, its calculations will be final and binding on all Holders. The Company will provide a schedule of its calculations to each of the Trustee and the Conversion Agent, and each of the
Trustee and Conversion Agent is entitled to rely conclusively upon the accuracy of the Company’s calculations without independent verification. If any Holder requests from the Trustee a copy of such schedule, the Trustee will promptly forward a
copy of such schedule to such Holder. 
 All calculations will be made to the nearest cent or to the nearest 1/10,000th of a
share, as the case may be, with 5/100,000ths rounded upward. 
 Section 12.10 Successors. 

All agreements of the Company, the Trustee, the Registrar, the Paying Agent and the Conversion Agent in this Indenture and the Notes will
bind their respective successors. 

  
 85 

 Section 12.11 Multiple Originals. 

The parties may sign any number of copies of this Indenture. Each signed copy will be an original, but all of them together represent the
same agreement. One signed copy is enough to prove this Indenture. The exchange of copies of this Indenture and of signature pages by facsimile or PDF transmission will constitute effective execution and delivery of this Indenture as to the
parties hereto and may be used in lieu of the original Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or PDF will be deemed to be their original signatures for all purposes. 

Section 12.12 Table of Contents; Headings. 
 The table of contents and headings of the articles and sections of this Indenture have been inserted for convenience of reference only, are not intended to be considered a part hereof, and will not modify
or restrict any of the terms or provisions hereof. 
 Section 12.13 Force Majeure. 

In no event shall the Trustee, the Registrar, the Paying Agent or the Conversion Agent be responsible or liable for any failure or delay
in the performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military
disturbances, nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which
are consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 
 Section 12.14 Submission to Jurisdiction. 
 The Company:
(a) agrees that any suit, action or proceeding against it arising out of or relating to this Indenture or the Notes, as the case may be, may be instituted in any U.S. federal court with applicable subject matter jurisdiction sitting in The City
of New York; (b) waives, to the fullest extent permitted by applicable law, any objection which it may now or hereafter have to the laying of venue of any such suit, action or proceeding, and any claim that any suit, action or proceeding
in such a court has been brought in an inconvenient forum; and (c) submits to the nonexclusive jurisdiction of such courts in any suit, action or proceeding. 
 Section 12.15 Legal Holidays. 
 If the Maturity Date or any Interest
Payment Date, Fundamental Change Repurchase Date, Redemption Date or Conversion Date is not a Business Day, then any action to be taken on such date need not be taken on such date, but may be taken on the immediately following Business Day with the
same force and effect as if taken on such date, and no interest will accrue for the period from and after such date. 

  
 86 

 Section 12.16 No Security Interest Created. 

Nothing in this Indenture or in the Notes, expressed or implied, will be construed to constitute a security interest under the Uniform Commercial Code or
similar legislation, as now or hereafter enacted and in effect, in any jurisdiction. 
 Section 12.17 Benefits of
Indenture. 
 Nothing in this Indenture or in the Notes, expressed or implied, will give to any Person, other than the
parties hereto, any Paying Agent, Conversion Agent, Registrar, and their successors hereunder, and the Holders any benefit or any legal or equitable right, remedy or claim under this Indenture. 

Section 12.18 U.S.A. Patriot Act. 
 The parties hereto acknowledge that in accordance with Section 326 of the U.S.A. Patriot Act, the Trustee, like all financial institutions, in order to help fight the funding of terrorism and money
laundering, is required to obtain, verify, and record information that identifies each Person or legal entity that establishes a relationship or opens an account with the Trustee. The parties to this Indenture agree that they will provide the
Trustee with such information as it may request in order for the Trustee to satisfy the requirements of the U.S.A. Patriot Act. 

[Signature Page Follows] 

  
 87 

 IN WITNESS WHEREOF, Sequenom, Inc. has caused this Indenture to be duly executed as a deed
the day and year first before written. 
 SEQUENOM, INC., as Issuer 

 

			
	By:	 	 /s/ Paul V. Maier

	Name:	 	Paul V. Maier
	Title:	 	CFO

 Signature Page – Sequenom, Inc. 5.00% Convertible Senior Notes Indenture 

 IN WITNESS WHEREOF, the undersigned, being duly authorized, has executed this Indenture as
of the day and year first before written. 
  

			
	WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee, Paying Agent, Registrar and Conversion Agent
		
	By:	 	 /s/ Maddy Hall

	Name:	 	Maddy Hall
	Title:	 	Vice President

 Signature Page – Sequenom, Inc. 5.00% Convertible Senior Notes Indenture 

 EXHIBIT A 

FORM OF NOTE 
 [FORM OF FACE OF NOTE] 
 NO AFFILIATE (AS DEFINED IN RULE 144 UNDER
THE SECURITIES ACT) OF THE COMPANY OR PERSON THAT HAS BEEN AN AFFILIATE (AS DEFINED IN RULE 144 UNDER THE SECURITIES ACT) OF THE COMPANY DURING THE IMMEDIATELY PRECEDING THREE MONTHS MAY PURCHASE, OTHERWISE ACQUIRE OR HOLD THIS NOTE OR A BENEFICIAL
INTEREST HEREIN. 
 [Include the following legend for Global Notes only (the “Global Notes
Legend”):] 
 THIS IS A GLOBAL NOTE WITHIN THE MEANING OF THE INDENTURE HEREINAFTER
REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITARY OR A NOMINEE OF THE DEPOSITARY, WHICH MAY BE TREATED BY THE COMPANY, THE TRUSTEE AND ANY AGENT THEREOF AS OWNER AND HOLDER OF THIS NOTE FOR ALL PURPOSES. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE COMPANY OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL NOTE WILL BE LIMITED TO
TRANSFERS IN WHOLE, BUT NOT IN PART, TO NOMINEES OF THE DEPOSITORY TRUST COMPANY, OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE AND TRANSFERS OF PORTIONS OF THIS GLOBAL NOTE WILL BE LIMITED TO TRANSFERS MADE IN ACCORDANCE WITH THE
RESTRICTIONS SET FORTH IN ARTICLE TWO OF THE INDENTURE REFERRED TO ON THE REVERSE HEREOF. 
 [Include the following
legend on all Notes that are Restricted Notes (the “Restricted Notes Legend”):] 

THE SALE OF THIS NOTE HAS NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, PRIOR
TO THE RESALE RESTRICTION TERMINATION DATE (AS DEFINED BELOW), THIS NOTE AND ANY SHARES OF COMMON STOCK ISSUABLE UPON CONVERSION OF THIS NOTE (AND ANY BENEFICIAL INTEREST HEREIN OR 

  
 A-1

 
THEREIN) MAY NOT BE OFFERED, RESOLD OR OTHERWISE TRANSFERRED, EXCEPT: 
  

	 	(A)	TO THE COMPANY OR ANY SUBSIDIARY THEREOF; 

  

	 	(B)	PURSUANT TO A REGISTRATION STATEMENT THAT HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT; 

 

	 	(C)	TO A PERSON THAT YOU REASONABLY BELIEVE TO BE A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT; OR 

 

	 	(D)	UNDER ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT (INCLUDING, IF AVAILABLE, THE EXEMPTION PROVIDED BY RULE 144 UNDER THE
SECURITIES ACT). 

 THE “RESALE RESTRICTION TERMINATION DATE” MEANS THE DATE: (A) THAT IS AT LEAST TWELVE MONTHS
AFTER THE ISSUE DATE; AND (B) ON WHICH THE COMPANY HAS INSTRUCTED THE TRUSTEE THAT THIS LEGEND WILL NO LONGER APPLY IN ACCORDANCE WITH THE PROCEDURES DESCRIBED IN THE INDENTURE. PRIOR TO ANY TRANSFER PURSUANT TO THE FOREGOING CLAUSE (D), THE
COMPANY AND THE TRUSTEE RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THEY MAY REASONABLY REQUIRE AND MAY RELY UPON TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT TO AN EXEMPTION FROM,
OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. 

  
 A-2

 No.: [            ] 

CUSIP: [            ] 
 ISIN: [            ] 
 Principal Amount $[            ] 
 [as revised by the Schedule of Increases 
 and Decreases of
Global Note attached hereto]1 

Sequenom, Inc. 
 5.00% Convertible Senior Notes due 2017 
 Sequenom,
Inc., a Delaware corporation, promises to pay to [            ],2 or registered assigns, the principal amount of $[            ] on October 1, 2017. 

Interest Payment Dates: April 1 and October 1 of each year, beginning April 1, 2013. 

Regular Record Dates: March 15 and September 15 of each year, beginning March 15, 2013. 

Additional provisions of this Note are set forth on the other side of this Note. 

 

	*	Upon the consummation of an automatic exchange, this Restricted Notes CUSIP will be deemed removed and replaced with the Unrestricted Notes CUSIP: 817337 AB4 and the
ISIN number will be deemed removed and replaced with ISIN number US817337AB40. 

  

	1 	Include for Global Notes only. 

	2 	Insert Cede & Co. for Global Notes. 

  
 A-3

 
			
	 SEQUENOM, INC.

		
	By:	 	  

	 Name:

	 Title:

	 Dated:

 Signature Page – Sequenom, Inc. 5.00% Convertible Senior Note 

 TRUSTEE’S CERTIFICATE OF AUTHENTICATION 

WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee, certifies that this is one of the Notes referred to in the within-mentioned
Indenture. 
  

			
	 By:
	 	  

	Authorized Signatory:
	Dated:

 Signature Page – Sequenom, Inc. 5.00% Convertible Senior Note 

 [FORM OF REVERSE OF NOTE] 

SEQUENOM, INC. 

5.00% Convertible Senior Notes due 2017 
 This Note is one of a duly authorized issue of notes of Sequenom, Inc. (the “Company”), designated as its 5.00% Convertible Senior Notes due 2017 (the “Notes”), all
issued or to be issued under and pursuant to an indenture dated as of the Issue Date (the “Indenture”), between the Company and Wells Fargo Bank, National Association (the “Trustee”), to which Indenture and all
indentures supplemental thereto reference is hereby made for a description of the rights, limitations of rights, obligations, duties and immunities thereunder of the Trustee, the Company and the Holders. Capitalized terms used herein and not defined
herein have the meanings ascribed to them in the Indenture, and the terms of the Notes include those stated in the Indenture and those incorporated into the Indenture. 
  

	1.	Interest. 

 This Note will
bear interest at a rate equal to 5.00% per annum. Interest on this Note will accrue from the Issue Date or from the most recent date to which interest has been paid or provided for. Interest will be payable semiannually in arrears in cash on
April 1 and October 1 of each year, beginning on April 1, 2013. Each payment of cash interest on this Note will include interest accrued for the period commencing on and including the immediately preceding Interest Payment Date (or,
if none, the Issue Date) through the day before the applicable Interest Payment Date. 
 Pursuant to Section 4.04 of the
Indenture, in certain circumstances, the Company will pay Additional Interest on this Note. 
 Pursuant to Section 6.04 of
the Indenture, in certain circumstances, the Company will pay an Extension Fee on this Note. 
  

	2.	Method of Payment. 

 The
Company will promptly make all payments on this Note on the dates and in the manner provided herein and in the Indenture. Payments on Notes represented by a Global Note (including principal and interest) will be made by wire transfer of immediately
available funds to the accounts specified by Depositary. The Company will pay principal of, and any Fundamental Change Repurchase Price or Redemption Price for, Definitive Notes at the office or agency designated by the Company for such purpose.
Interest on Definitive Notes will be made by check or by wire transfer, as described in Sections 2.04, except that any payment of Interest due on the Maturity Date will be made at the office or agency designated by the Company for such purpose. All
payments on this Note will be made in money of the United States that at the time of payment is legal tender for payment of public and private debts. 
  

	3.	Paying Agent, Conversion Agent and Registrar. 

  
 A-6

 Initially, Wells Fargo Bank, National Association will act as the Trustee, Paying Agent,
Conversion Agent and Registrar. The Company may appoint and change any Paying Agent, Conversion Agent or Registrar; provided, that the Company will maintain at least one Paying Agent, Conversion Agent and Registrar in the continental United
States. The Company or any of the Subsidiaries or any of their Affiliates may act as Paying Agent, Conversion Agent or Registrar. 
  

	4.	Repurchase By the Company at the Option of the Holder upon a Fundamental Change. 

At the option of the Holder, and subject to the terms and conditions of the Indenture, upon the occurrence of a Fundamental Change, each
Holder will have the right, at its option, to require the Company to repurchase for cash all of its Notes, or any portion of its Notes having a principal amount equal to $1,000 or an integral multiple of $1,000 in excess thereof, at a Fundamental
Change Repurchase Price equal to 100% of the principal amount of Notes to be purchased plus accrued and unpaid interest, if any, to but excluding, the Fundamental Change Repurchase Date, unless the Fundamental Change Repurchase Date occurs after a
Regular Record Date and before the Interest Payment Date corresponding to such Regular Record Date, in which case accrued and unpaid interest, if any, on the Notes will be paid to the Holders of such Notes as of the Close of Business on such Regular
Record Date. To exercise its purchase right, a Holder must comply with the procedures set forth in Article 3 of the Indenture. 
  

	5.	Redemption at the Option of the Company. 

 Prior to October 1, 2015, the Company may not redeem the Notes. Subject to the terms of the Indenture, on or after October 1, 2015, and prior to the Maturity Date, the Company may redeem all,
but not less than all, of the Notes if the Last Reported Sale Price of the Common Stock equals or exceeds 140% of the Conversion Price in effect on each of at least 20 Trading Days during the 30 consecutive Trading Day period ending on the Trading
Day immediately prior to the date the Company delivers the Redemption Notice for such redemption. Any Redemption Date must be at least 30, but not more than 60, calendar days after the date on which the Company delivers the applicable Redemption
Notice. The Redemption Price that the Company will pay for any Notes that it redeems will equal to 100% of the principal amount of Notes to be purchased plus accrued and unpaid interest, if any, to but excluding, the Redemption Date, unless the
Redemption Date occurs after a Regular Record Date and before the Interest Payment Date corresponding to such Regular Record Date, in which case accrued and unpaid interest, if any, on the Notes will be paid to the Holders of such Notes as of the
Close of Business on such Regular Record Date 
  

	6.	Conversion. 

 Subject to,
or upon, compliance with the provisions set forth in the Indenture, a Holder of this Note has the right, at such Holder’s option, to convert the principal amount hereof or any portion of such principal amount that is equal to $1,000 or an
integral multiple of $1,000 in excess thereof, into (i) a number of shares of Common Stock equal to the product of (A) the Conversion Rate in effect on the applicable Conversion Date and (B) the principal amount of Notes converted
divided by $1,000, rounded down to the nearest whole number, and (ii) an amount of cash equal to the product of (A) the fraction of a share of Common Stock eliminated 

  
 A-7

 
by such rounding and (B) the Last Reported Sale Price of the Common Stock on such Conversion Date. 
  

	7.	Denominations; Transfer; Exchange. 

 The Notes are in fully registered form, without coupons, in denominations of $1,000 of principal amount and integral multiples of $1,000 in excess thereof. A Holder may transfer or exchange Notes in
accordance with the Indenture. The Registrar may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and to pay any taxes and fees required by law or permitted by the Indenture. The Registrar need not
transfer or exchange any Notes in respect of which a Fundamental Change Repurchase Notice has been given and not withdrawn (except, in the case of a Note to be repurchased in part, the portion of the Note not to be repurchased), after the Company
has delivered a Notice of Redemption (except to the extent that Notes are converted or repurchased in part or the Company fails to pay the Redemption Price in accordance with Article 11 of the Indenture) or in respect of which a Conversion Notice
has been given (except, in the case of a Note to be converted in part, the portion of the Note not to be converted). 
  

	8.	Amendment, Supplement and Waiver. 

 Subject to certain exceptions, the Indenture permits the Indenture and the Notes to be amended or supplemented with the written consent of the Holders of at least a majority in aggregate principal amount
of the then outstanding Notes. In certain circumstances, the Company and the Trustee may also amend or supplement the Indenture or the Notes without the consent of any Holder. Subject to certain exceptions, the Indenture permits the waiver of
certain Events of Default or the noncompliance with certain provisions of the Indenture and of the Notes with the written consent of the Holders of at least a majority in aggregate principal amount of the then outstanding Notes. 

 

	9.	Defaults and Remedies. 

Subject to the following paragraph, if an Event of Default specified in the Indenture occurs and is continuing, the Trustee or the Holders
of at least 25% in principal amount of the Notes may declare all the Notes to be due and payable immediately by delivering notice to the Company. In addition, certain specified Events of Default will cause the Notes to become immediately due and
payable without the Holders taking any action. 
 If the Company so elects, the sole remedy for an Event of Default relating to
the Company’s failure to comply with the reporting obligations under Section 4.02 or 4.03 of the Indenture will, for the 270 days after the occurrence of such Event of Default, consist exclusively of the right to receive an Extension Fee
on the principal amount of the Notes. 
 Holders may not enforce the Indenture or the Notes except as provided in the Indenture.
The Trustee may refuse to enforce the Indenture or the Notes unless it receives indemnity or security reasonably satisfactory to it. Subject to certain limitations, Holders of a majority of the principal amount of the then outstanding Notes may
direct the Trustee in its exercise of any trust 

  
 A-8

 
or power. Subject to certain exceptions, the Trustee may withhold from Holders notice of any continuing Event of Default or Default if it determines that withholding notice is in their interest.

  

	10.	Persons Deemed Owners. 

The Holder of this Note will be treated as the owner of this Note for all purposes. 

 

	11.	Unclaimed Money or Notes. 

The Trustee and the Paying Agent will return to the Company upon written request any money or securities held by them for the payment of
any amount with respect to the Notes that remains unclaimed for two years, subject to applicable unclaimed property law. After return to the Company, Holders entitled to the money or securities must look to the Company for payment as general
creditors, unless an applicable abandoned property law designates another Person. 
  

	12.	Trustee Dealings with the Company. 

 The Trustee, in its individual or any other capacity, may become the owner or pledgee of Notes and may otherwise deal with and collect obligations owed to it by the Company or its Affiliates and may
otherwise deal with the Company or its Affiliates with the same rights it would have if it were not the Trustee. 
  

	13.	Calculations in Respect of Notes. 

 Except as otherwise provided in the Indenture, the Company will be responsible for making all calculations called for under the Notes and the Indenture. These calculations include, but are not limited to,
determinations of the Last Reported Sale Price of the Common Stock or any other security, accrued interest payable on the Notes and the Conversion Rate in effect on any Conversion Date. 
 The Company will make all these calculations in good faith and, absent manifest error, its calculations will be final and binding on all Holders. 

 

	14.	No Recourse Against Others. 

 A director, officer, employee or stockholder, as such, of the Company will not have any liability for any obligations of the Company under the Notes or the Indenture or for any claim based on, in respect
of or by reason of such obligations or their creation. By accepting a Note, each Holder waives and releases all such liability. The waiver and release are part of the consideration for the issue of the Notes. 

 

	15.	Authentication. 

 This
Note will not be valid until an authorized signatory of the Trustee manually signs the Trustee’s certificate of authentication on the other side of this Note. 
  

	16.	Abbreviations. 

  
 A-9

 Customary abbreviations may be used in the name of a Holder or an assignee, such as TEN COM
(=tenants in common), TEN ENT (=tenants by the entireties), JT TEN (=joint tenants with right of survivorship and not as tenants in common), CUST (=custodian), and U/G/M/A (=Uniform Gift to Minors Act). 

 

	17.	GOVERNING LAW. 

 THE
INDENTURE AND THE NOTES WILL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK BUT WITHOUT REGARD TO CHOICE OF LAWS OR CONFLICTS OF LAWS PROVISIONS THEREOF THAT WOULD REQUIRE THE APPLICATION OF THE LAWS OF ANY
OTHER JURISDICTION. 
  

	18.	CUSIP Numbers. 

 Pursuant
to a recommendation promulgated by the Committee on Uniform Note Identification Procedures, the Company has caused CUSIP numbers to be printed on the Notes and the Trustee may use CUSIP numbers in any notices as a convenience to Holders. No
representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice, and reliance may be placed only on the other identification numbers placed thereon. 

The Company will furnish to any Holder, upon written request and without charge, a copy of the Indenture which has in it the text of this
Note in larger type. Requests may be made to: 
 Sequenom, Inc. 
 3595 John Hopkins Court 
 San Diego, California 92121 

Attn: Chief Financial Officer 

  
 A-10

 CONVERSION NOTICE 

SEQUENOM, INC. 

5.00% Convertible Senior Notes due 2017 
 To convert this Note, check the box   ̈ 

To convert the entire principal amount of this Note, check the box   ̈ 

To convert only a portion of the principal amount of this Note, check the box   ̈  and
here specify the principal amount to be converted, which principal amount must equal $1,000 or an integral multiple of $1,000 in excess thereof: 
  

			
	 Signature Guaranteed

	
	  

	 Participant in a Recognized Signature

	 Guarantee Medallion Program

		
	 By:
	 	  

	Authorized Signatory

  
 A-11

 FUNDAMENTAL CHANGE REPURCHASE NOTICE 

5.00% Convertible Senior Notes due 2017 
 Wells Fargo Bank, National Association 
 707 Wilshire Blvd, 17th Floor 

MAC E2818-176 
 Los Angeles, CA 90017 

Facsimile: 213-614-3355 
 Attn: Sequenom, Inc.
Account Manager 
 The undersigned registered owner of this Note hereby acknowledges receipt of a notice from Sequenom, Inc.
(the “Company”) as to the occurrence of a Fundamental Change with respect to the Company and specifying the Fundamental Change Repurchase Date and requests and instructs the Company to pay to the Holder hereof in accordance with the
applicable provisions of the Indenture referred to in this Note (1) the entire principal amount of this Note, or the portion thereof (that is equal to $1,000 principal amount or an integral multiple of $1,000 in excess thereof) below
designated, and (2) if such Fundamental Change Repurchase Date does not occur during the period after a Regular Record Date and on or prior to the corresponding Interest Payment Date, accrued and unpaid interest, if any, thereon to, but
excluding, such Fundamental Change Repurchase Date. 
 Principal amount to be repaid (if less than all):
$            ,000 
  

			
	 Signature Guaranteed

	
	  

	 Participant in a Recognized Signature

	 Guarantee Medallion Program

		
	By:	 	  

		 	    Authorized Signatory

  
 A-12

 [Include for Global Note] 

SCHEDULE OF INCREASES AND DECREASES OF GLOBAL NOTE 
 Initial Principal Amount of Global Note: [            ] 

 

									
	 Date
	  	Amount of Increase
in
Principal
Amount of Global
Note	  	Amount of
Decrease in
Principal Amount
of Global Note	  	Principal Amount
of Global Note
After Increase or
Decrease	  	Notation
by
Registrar or Note
Custodian
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

  
 A-13

 EXHIBIT B 

FORM OF TRANSFER CERTIFICATE 
 SEQUENOM, INC. 
 5.00% Convertible Senior Notes due 2017 

Transfer Certificate 
 In connection with any transfer of any of this Note, the undersigned registered owner of this Note hereby certifies with respect to
$             principal amount of the above-captioned Notes presented or surrendered on the date hereof (the “Surrendered Note”) for registration of transfer, or for
exchange or conversion where the securities issuable upon such exchange or conversion are to be registered in a name other than that of the undersigned registered owner (each such transaction being a “Transfer”), that such Transfer
complies with the restrictive legend set forth on the face of the Surrendered Note for the reason checked below: 
  ̈  The Transfer of the Surrendered Note is being made to the Company or a Subsidiary thereof; or 
  ̈  The Transfer of the Surrendered Note complies with Rule 144A under the Securities Act; or 

 ̈  The Transfer of the Surrendered Note is being made pursuant to an effective
registration statement under the Securities Act; or 
  ̈  The Transfer
of the Surrendered Note is being made pursuant to another available exemption from the registration requirement of the Securities Act. 
 Date:
                                         
                                         
               
 By:
                                         
             
 (If the registered owner is a corporation,
partnership or fiduciary, the title of the Person signing on behalf of such registered owner must be stated.) 
  

			
	Signature Guaranteed
	
	  

	Participant in a Recognized Signature
	
	Guarantee Medallion Program
		
	 By:
	 	  

		 	Authorized Signatory

  
 B-1

 EXHIBIT C 

[FORM OF FREE TRANSFERABILITY CERTIFICATE] 
 Wells Fargo Bank, National Association 
 [    ] 

Re: CUSIP 817337 AA6 
 Dear Sir/Madam:

 Whereas the 5.00% Convertible Senior Notes due 2017 (the “Notes”) have become freely tradable without
restriction by non-affiliates of Sequenom, Inc. (the “Company”) pursuant to Rule 144(b)(1) under the Securities Act of 1933, as amended, in accordance with Section 2.10 of the indenture, dated as of September 17, 2012 (the
“Indenture”), between the Company and Wells Fargo Bank, National Association, as trustee, pursuant to which the Notes were issued, the Company hereby instructs you that: 

 

	 	(i)	the restrictive legends described in Section 2.10(a) of the Indenture and set forth on the Notes and Common Stock issued or issuable upon conversion of the Notes
will be deemed removed from the global securities representing such securities, in accordance with the terms and conditions of the Notes and as provided in the Indenture, without further action on the part of holders; and 

 

	 	(ii)	the Restricted Notes CUSIP number will be deemed removed from the Global Securities and replaced with the Unrestricted Notes CUSIP number set forth therein, in
accordance with the terms and conditions of the Notes and as provided in the Indenture, without further action on the part of holders. 

 Capitalized terms used but not defined herein have the meanings set forth in the Indenture. 
  

			
	Very truly yours,
	
	SEQUENOM, INC.
		
	 By:
	 	  

	 Name:

	 Title:

  
 C-1

 EXHIBIT D 

[FORM OF RESTRICTED STOCK LEGEND] 
 THE SALE OF THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE U.S. SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND ACCORDINGLY, PRIOR TO THE RESALE RESTRICTION TERMINATION DATE (AS
DEFINED BELOW), THIS SECURITY (AND ANY BENEFICIAL INTEREST HEREIN) MAY NOT BE OFFERED, RESOLD, OR OTHERWISE TRANSFERRED, EXCEPT: 
 TO THE COMPANY OR ANY SUBSIDIARY THEREOF; 
 PURSUANT TO A REGISTRATION STATEMENT
THAT HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT; 
 TO A PERSON THAT YOU REASONABLY BELIEVE TO BE A QUALIFIED INSTITUTIONAL
BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT; OR 
 UNDER ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT (INCLUDING, IF AVAILABLE, THE EXEMPTION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT). 
 THE “RESALE
RESTRICTION TERMINATION DATE” MEANS THE DATE: (A) THAT IS AT LEAST TWELVE MONTHS AFTER THE ISSUE DATE OF THE COMPANY’S 5.00% CONVERTIBLE SENIOR NOTES DUE 2017; AND (B) ON WHICH THE COMPANY HAS INSTRUCTED THE TRUSTEE THAT THIS
LEGEND WILL NO LONGER APPLY, IN ACCORDANCE WITH THE PROCEDURES DESCRIBED IN THE INDENTURE FOR THE NOTES. PRIOR TO ANY TRANSFER PURSUANT TO THE FOREGOING CLAUSE (D), THE COMPANY AND THE COMPANY’S TRANSFER AGENT RESERVE THE RIGHT TO REQUIRE THE
DELIVERY OF SUCH CERTIFICATIONS, LEGAL OPINIONS OR OTHER INFORMATION AS THEY MAY REASONABLY REQUIRE AND MAY RELY UPON TO CONFIRM THAT SUCH TRANSFER IS BEING MADE PURSUANT TO AN EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION
REQUIREMENTS OF THE SECURITIES ACT. 

  
 D-1EX-10.1

 Exhibit 10.1 
 EXECUTION COPY 
 EMPLOYMENT AGREEMENT 

This Employment Agreement (this “Agreement”) is entered into this 13th day of September, 2012, by and between Emisphere
Technologies, Inc., a Delaware corporation with offices at 240 Cedar Knolls Road, Suite 200, Cedar Knolls, NJ 07027 (the “Company”) and Alan L. Rubino residing at 210 Oldchester Road, Essex Fells, NJ 07021 (the “Executive”).

 RECITALS 
 WHEREAS, the Company and the Executive desire for the Executive to be employed by the Company as its President and Chief Executive Officer. 

NOW THEREFORE, in consideration of the mutual covenants contained herein, and other valuable consideration, the receipt and adequacy of
which are hereby acknowledged, and intending to be legally bound hereby, the parties do hereby agree as follows: 
 AGREEMENT

 1. Term. The term of this Agreement shall commence as of September 13, 2012 and shall end on September 12, 2015
(“Term”). The Term shall automatically renew for one year periods (each, a “Renewal Period”) unless either party provides the other party with written notice that this Agreement will not be renewed at least six (6) months
prior to the commencement of any Renewal Period. 
 2. Duties of Executive. 

(a) General Duties and Responsibilities. The Executive shall have such duties and authority consistent with the positions
of President and Chief Executive Officer as shall be assigned to him from time to time by the Board of Directors of the Company (the “Board”). The Company shall use its commercially reasonable efforts to ensure that Executive is elected as
a director of the Company within a reasonable time following the date this Agreement is executed by both parties and that he remains a director for the duration of his employment relationship with the Company. 

(b) Devotion of Entire Time to the Business of Company. The Executive agrees to devote his entire time and best efforts to
the performance of his duties for the Company (except for permitted vacation periods and reasonable periods of illness or other incapacity), and the Executive shall not, directly or indirectly, engage or participate in any other employment or
occupation, or in any activities which may conflict with his duties or the best interests of the Company. Notwithstanding the foregoing, nothing herein shall preclude the Executive from: (i) serving, with the prior written consent of the Board,
as a member of no more than three (3) board of directors or advisory boards (or their equivalents in the case of a non-corporate entity), which shall initially be serving as a Director on the Boards of Aastrom Biosciences (a public human stem
cell company), Genisphere (a private diagnostics company) and Bio-Cell Diagnostics North America, LLC (a private diagnostic equipment distribution company in 

 
whom Executive is an investor) and (ii) engaging in charitable activities and community affairs. The Board expressly reserves the right to withhold its consent to additional directorships
following the date hereof, and, in the event of an identified conflict of interest with respect to Executive’s duties and obligations to the Company, to withdraw its consent to the above named directorships and any other directorship approved
by the Board following the date hereof, in each case in its sole discretion. 
 3. Compensation and Benefits. 

(a) Base Salary. The Executive shall receive an annual base salary of $400,000 (the “Base Salary”) payable in
substantially equal installments in accordance with the Company’s normal payroll practices. 
 (b) Bonus. The
Executive shall be entitled to a target bonus of up to fifty percent (50%) of Base Salary per full calendar year of employment (for example, the bonus opportunity for the 2012 calendar year shall be $66,667.00 which is a pro-rated portion of
the full bonus opportunity of $200,000 for the remainder of the 2012 calendar year). The amount of the actual bonus shall be determined by the Board in its sole discretion based on goals prepared by the Executive annually and approved by the Board.
The bonus (the “Annual Bonus”) shall be paid on March 15 of the following year (the “Bonus Payment Date”), provided the Executive is actively employed as of the Bonus Payment Date. Notwithstanding the foregoing, if the
Company (A) terminates the Executive’s employment without Cause pursuant to Section 4(d) prior to the Bonus Payment Date (and prior to the last day of the calendar year with respect to which the Annual Bonus is to be paid), or
(B) provides notice of intent not to renew the Term pursuant to Section 1, the Executive shall receive a prorated portion of the Annual Bonus the Executive would have received but for his termination prior to the Bonus Payment Date (based
on the number of days the Executive remains in service during the calendar year with respect to which the Annual Bonus is to be paid), which prorated portion shall be paid in either case on the Bonus Payment Date. 

(c) Employee Benefit Programs. The Executive shall be entitled to participate in all formally established employee health
and welfare benefit plans and similar programs that are maintained for similarly situated employees of the Company, in accordance with the terms and conditions of such plans and programs, provided that the Company may at any time modify, discontinue
or terminate any such benefit plan or program now existing or hereafter adopted. If the Company discontinues or terminates its health benefit plan for all employees of the Company at any time during the Term or a Renewal Period, the Company shall
pay the Executive a taxable amount not to exceed the current annual Company-paid portion of the cost to provide Executive with family health insurance coverage (pro-rated as necessary for any partial year) per year. Any such payments shall be made
on a monthly basis for the remainder of the Term or any Renewal Period and may, but shall not be required to be used by the Executive to obtain replacement family health insurance coverage. 

  
 2 

 (d) Automobile Allowance. The Executive shall be entitled to receive an
automobile allowance in the amount of $1,000 per month of employment, pro rated for any partial month. 
 (e)
Equity. 
 The Executive shall be a participant in the Company’s 2007 Stock Award and Incentive Plan (the
“Plan”), and shall be granted Company stock options in accordance with the terms attached hereto as Exhibit A. Any additional stock options or equity compensation of any kind shall be in the Board’s sole discretion. 

(f) Vacation. The Executive shall be entitled to twenty (20) days of vacation per calendar year of his employment. For
2012, the Executive shall be entitled to eight (8) days of vacation. Any vacation shall be taken at the reasonable and mutual convenience of the Company and the Executive. The Executive may not carry over unused vacation from one calendar year
to the next, except with the consent of the Board, not to exceed ten (10) days, and (subject to applicable law) the Executive will not be paid for unused accrued vacation upon separation of his employment. 

(g) Expenses. The Company shall reimburse the Executive for reasonable business expenses necessarily incurred in the
ordinary course of the Executive’s duties and in accordance with the Company’s policies. 
 (h) Withholding
Taxes. The Company shall withhold from any amounts payable to the Executive any amount it is required to withhold pursuant to applicable law. 
 (i) Parachute Payments. Notwithstanding any other provision of this Agreement, in the event that any payment or other benefit received or to be received by the Executive pursuant to this
Agreement, together with any other payments or benefits provided to the Executive under any other plan, program, policy, arrangement or agreement (collectively, the “Payment”) would (but for this Section 3(i)) constitute a
“parachute payment” under Section 280G of the Internal Revenue Code of 1986, as amended (the “Code”), or would result in the imposition on the Executive of an excise tax under section 4999 of the Code or similar provision of
state or local law, then the Payment made to the Executive shall be reduced so that the aggregate present value of the Payment does not exceed three times the Executive’s “annualized includible compensation for the base period” (as
such phrase is defined in Section 280G(d)(1) of the Code) minus one dollar, with such reduction in the Payment being made in the manner that will result in the receipt by Executive of the greatest after-tax benefit as determined by the
Company’s independent public accountants (the “Accountants”). Unless the Company and the Executive otherwise agree in writing, any determination required under this Section 3(i) shall be made in writing by the Accountants whose
determination shall be conclusive and binding upon the Executive and the Company for all purposes. For purposes of making the calculations required by this paragraph, the Accountants may 

  
 3 

 
make reasonable assumptions and approximations concerning applicable taxes and may rely on reasonable, good faith interpretations concerning the application of Sections 280G and 4999 of the Code.
The Company and the Executive shall furnish to the Accountants such information and documents as the Accountants may reasonably request in order to make a determination under this Section 3(i). 

4. Termination of Employment. The Executive’s employment hereunder may be terminated as follows: 

(a) Automatically and immediately, in the event of the death of the Executive; 

(b) In the event of Permanent Disability, if the Company determines in good faith that the Executive has become disabled during the Term
or any applicable Renewal Period in which event the Company shall have the right to give the Executive notice of its intention to terminate his employment. In such event, the Executive’s employment shall terminate effective as of the 30th day
from the date of such notice, provided that, within the 30-day period after such receipt, the Executive shall not have returned to full-time performance of his duties. For purposes of this Agreement, “Permanent Disability” shall mean the
inability of the Executive to perform the essential functions of one or more of his primary duties as a result of his incapacity, despite any reasonable accommodation required by law, due to bodily injury or disease or any other mental or physical
illness, which inability continues for a period of one hundred eighty (180) days, which need not be consecutive, within any three hundred sixty five (365) day period; 

(c) Automatically and immediately upon providing notice to the Executive at the option of the Company, after approval by the Board, for
“Cause.” As used herein, “Cause” shall mean, in each case as determined in good faith by the Board: (i) the commitment by the Executive of any act involving fraud or moral turpitude, any act of dishonesty or breach of trust
in connection with Executive’s duties or obligations to the Company, (ii) willful misconduct or gross negligence by the Executive in the performance of his duties to the Company, or refusal to comply with any reasonable direction of the
Board, after the Executive has been notified of such event in writing and has had thirty (30) days from receipt of such notice to cure such event (if capable of being cured), (iii) conviction of any felony, or (iv) any material breach
by Employee of his confidentiality and non-solicitation obligations to the Company. 
 (d) At the option of the Company, at any
time without Cause on thirty (30) days’ prior written notice thereof to the Executive. 
 (e) At the option of the
Executive, at any time on thirty (30) days’ prior written notice thereof to the Company; or 
 (f) At the option of
the Executive for Good Reason upon written notice thereof to the Company as set forth in the final sentence of this Section 4(f). As used herein 

  
 4 

 
“Good Reason” shall be (i) the Company’s material breach of this Agreement; or (ii) the Company’s relocation of the Executive’s principal place of employment to
a location more than a 50 mile radius from Essex Fells, New Jersey; provided, however, that no such condition shall constitute Good Reason hereunder unless (i) the Executive notifies the Company in writing of his intent to terminate employment
for a reason set forth above within ninety (90) days of the initial existence of such condition; (ii) the Company fails to remedy such condition within thirty (30) days following its receipt of notice from the Executive pursuant to
clause (i) above; and (iii) any termination for such reason must take place within one hundred twenty (120) days following the initial existence of such condition. 
 5. Payments Upon Separation. 
 (a) Death. Upon the termination of
the Executive’s employment due to death, the Executive’s legal representatives shall be entitled to receive only (i) the Executive’s Base Salary payable through the date of such termination; (ii) reimbursement for reasonable
business expenses necessarily incurred by the Executive in the ordinary course of the Executive’s duties and in accordance with the Company’s policies; (iii) a prorated portion of the Annual Bonus the Executive would have received but
for his termination prior to the Bonus Payment Date, which prorated portion shall be paid on the Bonus Payment Date (the “Prorated Bonus Payment”); (iv) a prorated portion of benefits under the Plan that the Executive would have
received but for his termination (the “Prorated Plan Benefit”); and (v) provided the Executive’s spouse timely elects to continue family health insurance benefits under the federal law known as COBRA, the Company shall pay the
cost of such health insurance coverage at the same rate the Company contributed for family health insurance coverage prior to the Executive’s termination of employment with the Company until the earlier of twelve (12) months or the loss of
COBRA entitlement (the “Health Insurance Benefit”). Subsections (i) and (ii) of this Section 5(a) are hereinafter referred to as the “Accrued Rights”. Following the Executive’s termination of employment due to
death, except as set forth in this Section 5(a), the Executive and his legal representatives shall have no further rights to any compensation or any other benefits under this Agreement. 

(b) Disability. Upon the termination of the Executive’s employment due to Disability pursuant to Section 4(b),
the Executive or the Executive’s legal representatives shall be entitled to receive only the Accrued Rights (prorated for the period of time in which the Executive was actively at work on a full-time basis), the Prorated Bonus Payment (prorated
for the period of time in which the Executive was actively at work on a full-time basis), the Prorated Plan Benefit (prorated for the period of time in which the Executive was actively at work on a full-time basis), and the Health Insurance Benefit,
subject to the Executive’s timely COBRA election. Following the Executive’s termination of employment due to Disability, except as set forth in this Section 5(b), the Executive and the legal representatives shall have no further
rights to any compensation or any other benefits under this Agreement. 

  
 5 

 (c) Termination for Cause. Upon the termination of the Executive’s
employment hereunder by the Company for Cause pursuant to Section 4(c), the Executive shall be entitled to receive only the Accrued Rights. Following the Executive’s termination of employment by the Company for Cause, except as set forth
in this Section 5(c), the Executive shall have no further rights to any compensation or any other benefits under this Agreement. 
 (d) Termination Without Cause or For Good Reason. Upon the termination of the Executive’s employment hereunder by the Company without Cause pursuant to Section 4(d), or by the Executive
for Good Reason pursuant to Section 4(f), in each case other than in connection with a Change of Control as specified in Section 5(f) below, the Executive shall be entitled to receive (i) the Accrued Rights, and (ii) subject to
delivering to the Company an executed written general release of claims in favor of the Company and its affiliates in a form acceptable to the Company (the “Release”) within 21 days following the date the Executive has been given a copy of
the Release, and the expiration of the revocation period for such Release has become irrevocable by its terms within 7 days following the date the Executive returns the executed Release to the Company and, if he should be a director of the Company,
Executive’s resignation from the Board in accordance with Section 5(g) hereof, (A) the Prorated Bonus Payment; (B) the Prorated Plan Benefit; (C) provided the Executive timely elects to continue health insurance benefits
under the federal law known as COBRA, the Company shall pay the cost of family health insurance coverage at the same rate the Company contributed for the Executive’s family health insurance coverage prior to the Executive’s termination of
employment with the Company until the earlier of twelve (12) months or the loss of COBRA entitlement; provided, however, that the Executive shall be responsible for the cost of any continuation coverage under COBRA that extends beyond twelve
(12) months; and (D) his Base Salary in effect at termination, for twelve (12) months, payable in accordance with the normal payroll practices of the Company (the “Severance Benefit”). Following the Executive’s
termination of employment by the Company without Cause or For Good Reason, except as set forth in this Section 5(d), the Executive shall have no further rights to any compensation or any other benefits under this Agreement. 

(e) Resignation or Non-Renewal by the Executive or the Company. Upon the Executive’s resignation pursuant to
Section 4(e) or the non-renewal of the Term pursuant to Section 1 by the Executive or the Company, the Executive shall be entitled to receive only the Accrued Rights. Following the Executive’s termination of employment by his
resignation or expiration of the Term or any Renewal Period, except as set forth in this Section 5(e), the Executive shall have no further rights to any compensation or any other benefits under this Agreement. 

(f) Effect of Change of Control. In the event that, within twelve (12) months following a Change of Control, either:
(i) Executive’s employment is terminated without Cause, or (ii) Executive terminates his employment for Good Reason, then Executive shall be entitled to receive (i) the Accrued Rights, and (ii) subject to delivering to the
Company the 

  
 6 

 
Release within 21 days following the date the Executive has been given a copy of the Release, and the expiration of the revocation period for such Release has become irrevocable by its terms
within 7 days following the date the Executive returns the executed Release to the Company and, if he should be a director of the Company, Executive’s resignation from the Board in accordance with Section 5(g) hereof, (A) the Prorated
Bonus Payment; (B) the Prorated Plan Benefit; (C) provided the Executive timely elects to continue health insurance benefits under the federal law known as COBRA, the Company shall pay the cost of family health insurance coverage at the
same rate the Company contributed for the Executive’s family health insurance coverage prior to the Executive’s termination of employment with the Company until the earlier of twelve (12) months or the loss of COBRA entitlement;
provided, however, that the Executive shall be responsible for the cost of any continuation coverage under COBRA that extends beyond twelve (12) months; (D) his Base Salary in effect at termination, for eighteen (18) months, payable
in a lump sum within thirty (30) days; and (E) the vesting of all stock option grants set forth on Exhibit A, regardless of date or condition of vesting. If, upon the Change of Control, (i) the Company shall cease to be a stand-alone
publicly traded entity, or (ii) the acquiring entity is unwilling to assume the equity in an economically equivalent manner, then in either event, all equity shall be deemed to have vested two (2) days prior to the Change of Control, but
only if such Change of Control shall actually be consummated. Following the Executive’s termination of employment as described in this Section 5(f) or otherwise in connection with a Change of Control, except as set forth in this
Section 5(f), the Executive shall have no further rights to any compensation or any other benefits under this Agreement. 
 For the
purposes hereof, “Change of Control” shall mean (i) the acquisition by any individual, entity or group (within the meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of 1934, as amended (the “Exchange
Act”)), other than any individual, entity or group which, as of the date of this Agreement, beneficially owns more than ten percent (10%) of the then outstanding shares of common stock of the Company (the “Common Stock”), of
beneficial ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act) of fifty percent (50%) or more of the then outstanding Common Stock; provided, however, that any acquisition by the Company or its subsidiaries,
or any employee benefit plan (or related trust) of the Company or its subsidiaries of fifty percent (50%) or more of outstanding Common Stock shall not constitute a Change of Control, and provided, further, that any acquisition by
an entity with respect to which, following such acquisition, more than fifty percent (50%) of the then outstanding equity interests of such entity, is then beneficially owned, directly or indirectly, by all or substantially all of the
individuals and entities who were the beneficial owners of the outstanding Common Stock immediately prior to such acquisition of the outstanding Common Stock, shall not constitute a Change in Control; or (ii) the consummation of (A) a
reorganization, merger or consolidation (any of the foregoing, a “Merger”), in each case, with respect to which all or substantially all of the individuals and entities who were the beneficial owners of the outstanding Common Stock
immediately prior to such Merger do not, following such Merger, beneficially own, directly or indirectly, more than fifty percent 

  
 7 

 
(50%) of the then outstanding shares of common stock of the corporation resulting from Merger, or (iii) the sale or other disposition of all or substantially all of the assets of the
Company, excluding (a) a sale or other disposition of assets to a subsidiary of the Company; and (b) a sale or other disposition of assets to any individual, entity or group which, as of the date of this Agreement, beneficially owns more
than ten percent (10%) of the then outstanding Common Stock. 
 (g) Board Resignation as a Condition Precedent.
Executive agrees, as a condition to the receipt of the termination payments and benefits provided for in this Section 5, and notwithstanding giving the Release, that should Executive be a director of the Company he shall automatically be deemed
to have resigned from the Board of the Company whether or not such written resignation is tendered. 
 6. Invention, Non-Disclosure,
Non-Competition and Non-Solicitation Agreement. As a condition of employment and the benefits provided pursuant to this Employment Agreement, the Executive agrees to execute and abide by the terms of the Company’s Invention, Non-Disclosure,
Non-Competition and Non-Solicitation Agreement, a copy of which is attached hereto as Exhibit B. 
 7. Non-Disparagement.
The Executive agrees that he will not, during or after the Term or any applicable Renewal Period, make any disparaging statement about, or otherwise embarrass or criticize, the Company or the Company’s officers, directors or employees, or its
affiliates. 
 8. Cooperation. During and after the Term and any applicable Renewal Period, the Executive shall cooperate fully
with the Company in the defense or prosecution of any claims or actions now in existence or which may be brought in the future against or on behalf of the Company which relate to events or occurrences that transpired during anytime in which the
Executive was employed by the Company. The Company shall fairly compensate the Executive for his time and shall reimburse him for any reasonable out-of-pocket expenses incurred in connection with the Executive’s performance of obligations
pursuant to this Section 8. The Executive’s full cooperation in connection with such claims or actions shall include, but not be limited to, being available to meet with counsel to prepare for discovery or trial and to act as a witness for
the Company at mutually convenient times. 
 9. Assignment. Neither this Agreement nor any right or interest hereunder shall be
assignable by the Executive, the Executive’s beneficiaries or legal representatives, provided, that nothing in this Section 9 shall preclude the Executive from designating a beneficiary to receive any benefits payable hereunder upon the
Executive’s death or the executors, administrators or other legal representatives of the Executive or the Executive’s estate from assigning any rights hereunder to the person or persons entitled thereto. This Agreement may be assigned by
the Company without the consent of the Executive to a person or entity which is an affiliate or a successor in interest (by law or agreement) to substantially all of the assets or business operations of the Company. Upon any such assignment, the
rights and obligations of the Company hereunder shall become the rights and obligations of such affiliate or successor person or entity. 

  
 8 

 10. Arbitration. In consideration of the Company employing the Executive, and the salary and benefits
provided under this Agreement, the Executive and the Company agree that all claims arising out of or relating to the Executive’s employment including its termination, and excepting claims pursuant to the Confidentiality and Non-Solicitation
Agreement, which shall be resolved pursuant to the terms of that agreement, shall be resolved by binding arbitration. The dispute will be arbitrated in accordance with the rules of the AAA under its then existing Employment Arbitration Rules by a
single retired New Jersey Superior Court Judge agreed upon by the parties, or if no agreement can be reached, by a qualified arbitrator through AAA. Each party shall bear his/its own attorneys’ fees and legal costs. The parties agree to file
any demand for arbitration within the time limit established by the applicable statute of limitations for the asserted claims. This agreement to arbitrate will cover all matters directly or indirectly arising out of or related to the
Executive’s employment excepting only any claims that are expressly excepted under this Agreement or not subject to arbitration by law. The parties agree that all arbitration proceedings, and all materials provided by the parties in connection
therewith, shall be treated as confidential. Notwithstanding this agreement to arbitrate, either party may seek provisional injunctive or equitable relief in any court of competent jurisdiction to prevent actual or threatened irreparable harm. THE
PARTIES UNDERSTAND AND AGREE THAT THEY ARE WAIVING THEIR RIGHTS TO A JURY TRIAL. 
 11. Executive Acknowledgment. The Executive
acknowledges that he has had the opportunity to consult legal counsel and a tax advisor in regard to this Agreement, and that he read and understands this Agreement. The Executive is fully aware of the legal effect of this Agreement and has entered
into it freely and voluntarily and based on his own judgment and not based on any representations or promises other than those contained herein. 
 12. Entire Agreement. This Agreement and the Company’s Confidentiality and Non-Solicitation Agreement contain the entire understanding of the parties with respect to the employment of
the Executive by the Company and supersede any prior agreements between the parties relating to the subject matter herein, which agreements are hereby mutually terminated and cancelled. There are no restrictions, agreements, promises, warranties,
covenants or undertakings between the parties with respect to the subject matter herein other than those expressly set forth herein. This Agreement may not be altered, modified, or amended except by written instrument signed by the parties hereto.

 13. Waiver. No term or condition of this Agreement shall be deemed to have been waived, nor shall there be an estoppel against
the enforcement of any provision of this Agreement, except by written instrument of the party charged with such waiver or estoppel. No such written waiver shall be deemed a continuing waiver, unless specifically stated therein, and each waiver shall
operate only as to the specific term or condition waived and shall not constitute a waiver of such term or condition for the future or as to any act other than the act specifically waived. 

  
 9 

 14. Headings. The headings of the sections herein are included solely for convenience of
reference and shall not control the meaning or interpretation of any of the provisions of this Agreement. 
 15. Governing Law. This
Agreement shall be governed by and construed in accordance with the laws of the State of New Jersey, without regard to conflicts of laws principles thereof that would direct the applicable of the law of any other jurisdiction. 

16. Notices. Any notice or other communication required or permitted pursuant to this Agreement shall be deemed delivered if such notice or
communication is in writing and is delivered personally or by facsimile transmission or by email or is deposited in the United States mail, postage prepaid, addressed as follows: 

If to the Company: 
 Emisphere Technologies, Inc. 
 Attn: Corporate Secretary 

240 Cedar Knolls Road 
 Cedar Knolls, NJ 07027 
 Fax No.: 973-532-8121 

Email:mgarone@emisphere.com 
 Copy to: 
 Pierce Atwood LLP 

100 Summer Street, Suite 2250 
 Boston, MA 02110 
 Attn: Timothy C. Maguire 

If to the Executive, to the following address: 
 Alan L. Rubino 
 210 Oldchester Road 

Essex Fells, NJ 07021 
 Fax No.: 973- 
 Email:alanrubino@comcast.net 

Copy to: 

James M. Piro, 

Esq. Piro Zinna 

360 Passaic Avenue 
 Nutley, NJ 07110 
 Fax No.: 973-661-5157 

Email: jpiro@pirozinnalaw.com 

  
 10 

 17. Execution By All Parties. This Agreement shall not be binding or enforceable unless and
until executed on behalf of all parties hereto and may be executed in counterparts. 
 [Remainder of Page Intentionally Left
Blank] 

  
 11 

 IN WITNESS WHEREOF, and intending to be legally bound hereby, the parties hereto have caused
this Agreement to be duly executed as of the date and year first above written. 
  

			
	COMPANY
	
	EMISPHERE TECHNOLOGIES, INC.
		
	By:	 	 /s/ Michael R. Garone

			
	Name:	 	Michael R. Garone
	Title:	 	Interim Chief Executive Officer and Chief Financial Officer
	
	EXECUTIVE
	
	 /s/ Alan L. Rubino

	Alan L. Rubino

  
 12 

 Exhibit A 
 Stock Option Grant 
 Stock Option Grant 

Option Grant: The right to purchase two million (2,000,000) shares of common stock of the Company, par value $.01 per share (“Common
Stock”). The options shall become vested and exercisable as follows, subject to the terms and conditions of the fully-executed stock option grant agreement between the Company and Executive: 

 

							
	 Date
	  	Number of
Shares Vested	 	  	 Strike Price

	 January 1, 2013
	  	 	500,000	  	  	 Closing price of the Common Stock on September 13, 2012

	 September 13, 2014
	  	 	500,000	  	  	 $0.25 per share

	 September 13, 2015
	  	 	500,000	  	  	 $0.75 per share

	 September 13, 2016
	  	 	500,000	  	  	 $1.00 per share

  
 13 

 Exhibit B 
 Invention, Non-Disclosure, Non-Competition, and Non-Solicitation Agreement 
 (see
attached) 

  
 14 

 EMPLOYEE INVENTION, NON-DISCLOSURE, NON-COMPETITION AND 

NON-SOLICITATION AGREEMENT 
 This Employee Invention, Non-Disclosure, Non-Competition and Non-Solicitation Agreement (hereinafter referred to as the “Agreement”) is dated as of September 13, 2012 (hereinafter
referred to as the “Effective Date”) and is between Emisphere Technologies, Inc., a Delaware corporation (hereinafter the “Company”), having a place of business at 240 Cedar Knolls Road, Suite 200, Cedar Knolls, New Jersey 07027,
and Alan L. Rubino, an individual residing at 210 Oldchester Road, Essex Fells, New Jersey 07021 (hereinafter referred to in the first person as “I,” “me” or “my”). 

In consideration for the salary, bonus and benefits received under my certain Employment Agreement with the Company dated of even date
herewith, and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, I hereby agree as follows: 
 1. Inventions and Patents. 
 (a) I will promptly and fully disclose to the
Company any and all inventions, discoveries, trade secrets and improvements, whether or not patentable and whether or not they are made, conceived or reduced to practice during working hours or using the Company’s data or facilities, which I
develop, make, conceive or reduce to practice during my employment by the Company, either solely or jointly with others (collectively, the “Developments”). All Developments shall be the sole property of the Company, and I hereby assign to
the Company, without further compensation, all my right, title and interest in and to the Developments and any and all related patents, patent applications, copyrights, copyright applications, trademarks, trademark applications and trade names in
the United States and elsewhere. Notwithstanding the foregoing, Developments shall not include any inventions, discoveries, trade secrets or improvements that: (i) are not made, conceived or reduced to practice using the Company’s
information, data or facilities; and (ii) do not relate to the present business of the Company, any business that is competitive therewith, or any future business in which the Company engages. 

(b) I will keep and maintain adequate and current written records of all Developments (in the form of notes, sketches, drawings and as
may be specified by the Company), which records shall be available to and remain the sole property of the Company at all times. 

(c) I will assist the Company in obtaining and enforcing patent, copyright and other forms of legal protection for the Developments in
any country. Upon request, I will sign all applications, assignments, instruments and papers and perform all acts necessary or desired by the Company to assign all such Developments fully and completely to the Company and to enable the Company, its
successors, assigns and nominees, to secure and enjoy the full and exclusive benefits and advantages thereof. I 

  
 15 

 
understand that my obligations under this Paragraph 1 will continue after the termination of my employment with the Company and that during my employment I will perform such obligations without
further compensation, except for reimbursement of expenses incurred at the request of the Company. 
 (d) In addition to my
agreements set forth in subparagraph 1(c), I hereby constitute and appoint the Company, its successors and assigns, my true and lawful attorney, with full power of substitution for me, and in my name, place and stead or otherwise, but on behalf of
and for the benefit of the Company, its successors and assigns, to take all actions and execute all documents on behalf of me necessary to effect the assignment set forth in subparagraph 1(a), and from time to time to institute and prosecute in my
name or otherwise, but at the direction and expense and for the benefit of the Company and its successors and assigns, any and all proceedings at law, in equity or otherwise, which the Company, its successors or assigns may deem proper in order to
collect, assert or enforce any claim, right or title of any kind in and to the Developments and to defend and compromise any and all actions, suits and proceedings in respect of any of the Developments and to do any and all such acts and things in
relation thereto as the Company, its successors or assigns shall deem advisable, and I hereby declare that the appointment hereby made and the powers hereby granted are coupled with an interest and are and shall be irrevocable by me in any manner or
for any reason. 
 (e) In order to avoid disputes over the application of this assignment to prior inventions or copyrightable
materials, I have listed on Schedule A to this Agreement descriptions of patentable inventions and copyrightable materials that I have developed and/or reduced to practice prior to my employment with the Company and that I believe are,
accordingly, excepted from the provisions of this Paragraph 1. 
 2. Proprietary Information. 

(a) I recognize that my relationship with the Company is one of high trust and confidence by reason of my access to and contact with the
trade secrets and confidential and proprietary information of the Company and of others through the Company. I will not at any time, either during my employment with the Company or thereafter, disclose to others, or use for my own benefit or the
benefit of others, any of the Developments or any confidential, proprietary or secret information owned, possessed or used by the Company (collectively, “Proprietary Information”). Such property shall not be erased, discarded or destroyed
without specific instructions from the Company to do so. By way of illustration, but not limitation, Proprietary Information includes trade secrets, processes, data, know-how, marketing plans, forecasts, financial statements, budgets, licenses,
prices, costs and employee, customer and supplier lists and any other information which is not generally known to the public and which gives the Company the opportunity to obtain advantage over competitors who do not know or use such information,
such as research and development data, techniques, formulas, clinical methods, clinical results, marketing strategies, management techniques, technical information relating to organic 

  
 16 

 
chemistry, physical chemistry, analytical, pre-clinical, quality control, quality assurance, product development, manufacturing processes, manufacturing techniques, quality control and assurance
methods and procedures, information systems, information technologies and development, and information regarding the Company’s customers and/or partners, including but not limited to customer profiles, demographic data, marketing plans, sales
data, preferences, other business cycles, buying patterns, pricing and discounting, key contact personnel, special requirements, financial and/or contractual relations, job orders, requisitions, bids and bidding practices, unpublished promotional
material, and related information. I understand that the Company from time to time has in its possession information which is claimed by others to be proprietary and which the Company has agreed to keep confidential. I agree that all such
information shall be Proprietary Information for purposes of this Agreement. 
 (b) My undertaking and obligations under this
Paragraph 2 will not apply, however, to any Proprietary Information which: (i) is or becomes generally known to the public through no action on my part; (ii) is generally disclosed by the Company to third parties without restriction on
such third parties; (iii) is approved for release by written authorization of the Board of Directors of the Company (the “Board”); or (iv) is required to be disclosed pursuant to subpoena, order of judicial or administrative
authority, or in connection with judicial proceedings to which the Company or I am a party, provided that I shall have given the Company written notice of such disclosure at least 14 days prior to such disclosure in order to provide the Company with
an opportunity to oppose and/or object to such disclosure and any such disclosure is subject to all applicable governmental and judicial protection available for like material. 

(c) Upon termination of my employment with the Company or at any other time upon request, I will promptly deliver to the Company all
copies of computer programs, specifications, drawings, blueprints, data storage devices, notes, memoranda, notebooks, drawings, records, reports, files and other documents (and all copies or reproductions of such materials) in my possession or under
my control, whether prepared by me or others, in whatever form on whatever tangible medium, which contain Proprietary Information. I acknowledge that this material is the sole property of the Company, which I shall not retain. 

(d) If requested to do so by the Company, I agree to sign a Termination Certificate in which I confirm that I have complied with the
requirements of the preceding paragraph and that I am aware that certain restrictions imposed upon me by this Agreement continue after termination of my employment. I understand, however, that my rights and obligations under this Agreement will
continue even if I do not sign a Termination Certificate. 

  
 17 

 3. Absence of Restrictions Upon Disclosure and Competition. 

(a) I hereby represent that, except as I have disclosed in writing to the Company, and included in Schedule A to this
Agreement, I am not bound by the terms of any agreement with any previous employer or other party to refrain from using or disclosing any trade secret or information in the course of my employment with the Company or to refrain from competing,
directly or indirectly, with the business of such previous employer or any other party. 
 (b) I further represent that my
performance of all the terms of this Agreement and as an employee of the Company does not and will not breach any agreement to keep in confidence any information, knowledge or data acquired by me prior to my employment with the Company, and I will
not disclose to the Company or induce the Company to use any confidential information or material belonging to any previous employer or others. 
 4. Non-Compete/Non-Solicitation 
 (a) During the term of my employment with
the Company, I will not without the express written consent of the Company, directly or indirectly, engage in, participate in, or assist, as owner, part-owner, partner, director, officer, trustee, employee, agent or consultant, or in any other
capacity, any business organization or person whose activities or products are directly or indirectly competitive with activities or products of the Company. 
 (b) For so long as I am employed by the Company and for a period of 12 full months thereafter, I will not without the express written consent of the Company, directly or indirectly, engage in, participate
in, or assist, as owner, part-owner, partner, director, officer, trustee, employee, agent or consultant, or in any other capacity, any business organization or person, anywhere in the world where the Company does business whose products are directly
or indirectly competitive with products of the Company, or whose principal business is oral drug delivery systems technology. For purposes of this Section 4, “products of the Company” shall mean (i) oral B-12 products, alone or
in combination with other nutritional supplements; or (ii) other products marketed or in development by the Company during the term of my employment. 
 (c) I recognize that these restrictions on competition are reasonable because of the Company’s investment in good will and in its intellectual property, technology and professional and collaborative
relationships and other proprietary information and my knowledge of the Company’s business and business plans. However if any period of time or geographical area should be judged unreasonable in any judicial proceeding, then the period of time
or geographical area shall be reduced to such extent as may be deemed required so as to be reasonable and enforceable. 

  
 18 

 (d) During my employment with the Company and for 12 full months thereafter, I will notify
the Company in the event I take up a position of any sort with any company or person whose activities or products are directly or indirectly competitive with activities or products of the Company. I recognize and agree that nothing in this
Section 4(d) or any notice provided hereunder shall constitute consent by the Company or the Board with respect to such occurrence or a waiver or modification of the restrictions set forth in Sections 4(a) and 4(b) hereof. 

(e) I shall not recruit or otherwise solicit or induce any employees of the Company, to terminate their employment with, or otherwise
cease their relationships with, the Company or any of its subsidiaries during my employment with the Company and for a period of 12 full months thereafter. In addition, I shall not recruit or otherwise solicit any person who was an employee of the
Company during any time within six months prior to the end of my employment with the Company. 
 5. Other Obligations and
Agreements. 
 (a) I acknowledge that the Company from time to time may have agreements with others which impose obligations
or restrictions on the Company regarding inventions made during the course of work under such agreements or regarding the confidential nature of such work. I agree to be bound by all such obligations and restrictions which are made known to me and
to take all action necessary to discharge the obligations of the Company under such agreements. 
 (b) I agree that I will
advise any prospective employers of the covenants and restrictions of this Agreement, and authorize the Company to advise any other company or person of the existence and terms of this Agreement. 

6. Miscellaneous. 
 (a) The partial or complete invalidity or unenforceability of any provision of this Agreement shall not affect the validity or enforceability of any other provision of this Agreement. 

(b) This Agreement supersedes all prior agreements, written or oral, between me and the Company relating to the subject matter of this
Agreement. This Agreement may not be modified, changed or discharged in whole or in part, except by an agreement in writing signed by me and the Company. This Agreement does not constitute an employment agreement, and no changes in my compensation,
title or duties or any other terms or conditions of my employment, including, without limitation, the termination of my employment, shall affect the provisions of this Agreement except as stated herein. 

(c) As used herein, the term “Company” shall include Emisphere Technologies, Inc. and any of its predecessors, subsidiaries,
subdivisions or affiliates. The Company shall have the right to assign this Agreement to its successors and assigns and all 

  
 19 

 
covenants and agreements hereunder shall inure to the benefit of and be enforceable by said successors or assigns. I agree not to assign any of my obligations under this Agreement. This Agreement
will be binding upon my heirs, executors and administrators. 
 (d) No delay or omission by the Company in exercising any right
under this Agreement will operate as a waiver of that or any other right. A waiver or consent given by the Company on any one occasion is effective only in that instance and will not be construed as a bar to or waiver of any right on any other
occasion. 
 (e) I expressly consent to be bound by the provisions of this Agreement for the benefit of the Company or any
subsidiary or affiliate thereof to whose employ I may be transferred without the necessity that this Agreement be re-signed at the time of such transfer. 
 (f) This Agreement shall be deemed to be a sealed instrument and shall be governed by and construed in accordance with the laws of the State of New Jersey (without regard to its conflict of law
provisions). The Company and I hereby expressly consent to the jurisdiction of the courts of New Jersey to adjudicate any dispute arising under this Agreement. 
 (g) I recognize that irreparable damages would be caused to the Company, and that monetary damages would not compensate the Company for its loss, should I breach the terms of this Agreement. Accordingly,
in addition to all other remedies available to the Company at law or in equity, upon an adjudication by a court of a competent jurisdiction that I have violated or am about to violate the terms of this Agreement, I hereby consent to the entry by a
court of competent jurisdiction of an injunction or declaratory judgment enforcing the terms of this Agreement, including without limitation preventing disclosure or further disclosure by me of Proprietary Information. 

(h) If any one or more provisions of this Agreement shall for any reason be held to be excessively broad as to time, duration,
geographical scope, activity or subject, it shall be construed, by limiting and reducing it, so as to be enforceable to the extent compatible with the applicable law as it shall then appear. 

[SIGNATURE PAGE FOLLOWS] 

  
 20 

 I HAVE READ ALL OF THE PROVISIONS OF THIS AGREEMENT AND I UNDERSTAND, AND AGREE TO, EACH OF
SUCH PROVISIONS, EFFECTIVE AS OF THE DATE FIRST ENTERED ABOVE. BY SIGNING BELOW, I ACKNOWLEDGE AND AGREE THAT (A) THE COVENANTS AND RESTRICTIONS OF THIS AGREEMENT ARE REASONABLE AND NECESSARY FOR THE PROTECTION OF THE COMPANY’S BUSINESS;
(B) I AM ENTERING INTO THIS AGREEMENT VOLUNTARILY AND OF MY OWN FREE WILL IN ORDER TO OBTAIN THE BENEFITS OF EMPLOYMENT BY THE COMPANY, I HAVE NOT BEEN COERCED BY THE COMPANY OR ANY OTHER PARTY TO ENTER INTO THIS AGREEMENT, AND I HAVE CONSULTED
WITH LEGAL COUNSEL WITH RESPECT TO THE TERMS OF THIS AGREEMENT. 
  

			
	  

	Alan L. Rubino
		
	Date:	 	

 Accepted and agreed to: 
  

					
	EMISPHERE TECHNOLOGIES, INC.
		
	By:	 	  

		 	Name: Michael R. Garone
		 	Title: Chief Financial Officer

  

					
	Dated:	 	

  
 21 

 SCHEDULE A 
 Prior Inventions, Copyrights, Confidentiality Obligations, etc. 

  
 22

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