Document:

Medidata Solutions, Inc. Amended and Restated 2000 Stock Option Plan.

 Exhibit 10.3 
 As amended through January 15, 2009 
 MEDIDATA SOLUTIONS, INC. 
 AMENDED AND RESTATED 2000 STOCK OPTION PLAN 
 1. Purposes of the Plan. The purposes of this Stock Option Plan are to attract and retain the best available personnel for positions of substantial responsibility, to provide additional incentives to Employees, Directors and
Consultants and to promote the success of the Company’s business. Options granted under the Plan may be Incentive Stock Options or Nonstatutory Stock Options, as determined by the Administrator at the time of grant. 
 2. Definitions. As used herein, the following definitions apply: 
 “Administrator” means the Board or any of its Committees as shall be administering the Plan in accordance with Section 4 hereof. 
 “Applicable Laws” means the requirements relating to the administration of stock options under U.S. state corporate laws, U.S. federal
and securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any foreign country or jurisdiction where Options are granted under the Plan. 
 “Appraised Fair Market Value” means the fair market value of such share as determined by an independent appraisal obtained by the
Administrator for the express purpose of valuing the Company’s Option Shares under this Plan. 
 “Beneficial Owner”
shall have the meaning set forth in Rule 13d-3 under the Exchange Act. 
 “Board” means the Board of Directors of the
Company. 
 “Cause” means (i) willful malfeasance or gross negligence in the performance of an Employee’s duties
on behalf of the Company, (ii) engaging in misconduct which materially injures the financial condition or business reputation of the Company, or (iii) repeatedly refusing or failing to perform properly assigned duties on behalf of the
Company, which refusal or failure extends for more than 30 days after receipt of written notice thereof from the Company. 
 “Change
in Control” means the occurrence of any one of the following events: 
 (i) any Person becomes the Beneficial Owner, directly or
indirectly, of securities of the Company representing 50% or more of the combined voting power of the Company’s then outstanding voting securities; or 
 (ii) there is consummated a merger or consolidation of the Company with any other corporation or other entity, other than (A) a merger or consolidation which would result in the voting securities of the Company
outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving or parent entity) more than 50% of the combined voting power of the voting securities of the
Company or such surviving or patent entity outstanding immediately after such merger or consolidation or (B) a merger or consolidation effected to implement a recapitalization of the Company (or similar transaction) in which no Person, directly
or indirectly, acquired 50% or more of the combined voting power of the Company’s then outstanding securities; or 
 (iii) the
stockholders of the Company approve a plan of complete liquidation of the Company or there is consummated an agreement for the sale or disposition by the Company of all or substantially all of the Company’s assets (or any transaction having a
similar effect), other than a sale or disposition by the Company of all or substantially all of the Company’s assets to an entity, at least 50% of the combined voting power of the voting securities of which are owned by stockholders of the
Company in substantially the same proportions as their ownership of the Company immediate prior to such sale. 
  

 “Code” means the Internal Revenue Code of 1986, as amended. 
 “Committee” means a committee of Directors appointed by the Board in accordance with Section 4 hereof. 
 “Common Stock” or “Stock” means the common stock of the Company. 
 “Company” means MediData Solutions, Inc., a Delaware corporation. 
 “Consultant” means any person who is engaged by the Company or any Parent or Subsidiary to render consulting or advisory services to
such entity. 
 “Director” means a member of the Board. 
 “Employee” means any person, including officers and Directors, employed by the
Company or any Parent or Subsidiary of the Company. A Service Provider shall not cease to be an Employee in the case of (i) any leave of absence approved by the Company or (ii) transfers between locations of the Company or between the
Company, its Parent, any Subsidiary or any successor. For purposes of Incentive Stock Options, no such leave may exceed 90 days, unless reemployment upon expiration of such leave is guaranteed by statute or contract. If reemployment upon expiration
of a leave of absence approved by the Company is not so guaranteed, on the 181st day of such leave any Incentive Stock Option held by the Optionee
shall cease to be treated as an Incentive Stock Option and shall be treated for tax purposes as a Nonstatutory Stock Option. Neither service as a Director nor payment of a director’s fee by the Company shall be sufficient to constitute
“employment” by the Company. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Fair Market Value” means, as of any date, the value of Common Stock determined as follows: 
 (i) If the Common Stock is listed on any established stock exchange or a national market system including, without limitation, the NASDAQ National Market
System or the NASDAQ SmallCap Market of the NASDAQ Stock Market, its Fair Market Value shall be the closing sales price for such Stock (or the closing bid, if no sales were reported) as quoted on such exchange or system for the last market trading
day prior to the time of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
 (ii) If the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported, its Fair Market Value shall be the mean between the high bid and low asked prices for the Common Stock on the last market
trading day prior to the day of determination; or 
 (iii) In the absence of an established market for the Common Stock, the Fair Market
value thereof shall be determined in good faith by the Administrator. 
 “Incentive Stock Option” means an Option intended
to qualify as an incentive stock option within the meaning of Section 422 of the Code. 
 “IPO” means a firm commitment
underwritten initial public offering of the Company’s equity securities which has been declared effective pursuant to the Securities Act of 1933, as amended. 
  

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 “Nonstatutory Stock Option” means an Option not intended to qualify as an Incentive
Stock Option. 
 “Option” means a stock option granted pursuant to the Plan. 
 “Option Agreement” means a written or electronic agreement between the Company and an Optionee evidencing the terms and conditions of an
individual Option grant. The Option Agreement is subject to the terms and conditions of the Plan. 
 “Option Exchange
Program” means a program whereby outstanding Options are exchanged for Options with a lower exercise price. 
 “Option
Shares” means the shares of Common Stock subject to an Option. 
 “Optionee” means the holder of an outstanding
Option granted under the Plan. 
 “Parent” means a “parent corporation,” whether now or hereafter existing, as
defined in Section 424(e) of the Code. 
 “Person” means the meaning set forth in Section 3(a)(9) of the Exchange
Act, as modified and used in Sections 13(d) and 14(d)(2) thereof, except that such term shall not include (i) the Company, (ii) a trustee or other fiduciary holding securities under an employee benefit plan of the Company, (iii) an
underwriter temporarily holding securities pursuant to an offering of such securities or (iv) a corporation owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their ownership of shares of
Stock of the Company. 
 “Plan” means this 2000 Stock Option Plan. 
 “Service Provider” means an Employee, Director or Consultant. 
 “Share” means a share of the Common Stock, as adjusted in accordance with Section 12 below. 
 “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as defined in Section 424(f) of the
Code. 
 “Unexercised Option Shares” means those Shares that are covered by a particular Option granted hereunder to the
extent not exercised as of the date of such determination. 
 3. Stock Subject to the Plan. Subject to the provisions of
Section 12 of the Plan, the maximum aggregate number of Shares which may be subject to option and sold under the Plan is Three Million Eight Hundred Fifty Three Thousand Nine Hundred and Six (3,853,906) Shares (after giving effect to the
two-for-one stock split effected on August 3, 2004). The Shares may be authorized but unissued, or reacquired Common Stock. 
 If an
Option expires or becomes unexercisable without having been exercised in full, or is surrendered pursuant to an Option Exchange Program, the unpurchased Shares which were subject thereto shall become available for future grant or sale under the Plan
(unless the Plan has terminated). However, Shares that have actually been issued under the Plan, upon exercise of an Option, shall not be returned to the Plan and shall not become available for future distribution under the Plan. 
  

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 4. Administration of the Plan. 
 (a) The Plan shall be administered by the Board or a Committee appointed by the Board, which Committee shall be constituted to comply with Applicable
Laws. 
 (b) Powers of the Administrator. Subject to the provisions of the Plan and, in the case of a Committee, the specific duties
delegated by the Board to such Committee, and subject to the approval of any relevant authorities, the Administrator shall have the authority in its discretion: 
 (i) to determine the Fair Market Value; 
 (ii) to select the Service Providers to whom Options may from
time to time be granted hereunder; 
 (iii) to determine the number of Shares to be covered by each such award granted hereunder;

 (iv) to approve forms of agreement for use under the Plan; 
 (v) to determine the terms and conditions of any Option granted hereunder. Such terms and conditions include, but are not limited to, the exercise
price, the time or times when Options may be exercised (which may be based on performance criteria), any vesting or acceleration or waiver of forfeiture restrictions, and any restriction or limitation regarding any Option, based in each case on such
factors as the Administrator, in its sole discretion, shall determine; 
 (vi) to determine whether and under what circumstances an Option
may be settled in cash under subsection 9(e) instead of Common Stock; 
 (vii) to reduce the exercise price of any Option to the then
current Fair Market Value if the Fair Market Value of the Common Stock covered by such Option has declined since the date the Option was granted; 
 (viii) to initiate an Option Exchange Program; 
 (ix) to prescribe, amend and rescind rules and regulations relating to sub-plans
established for the purpose of qualifying for preferred tax treatment under foreign tax laws; 
 (x) to allow Optionees to satisfy
withholding obligations be electing to have the Company withhold from the Shares to be issued upon exercise of an Option that number of Shares having a Fair Market Value equal to the amount required to be withheld. The Fair Market Value of the
Shares to be withheld shall be determined on the date that the amount of tax to be withheld is to be determined. All elections by Optionees to have Shares withheld for this purpose shall be made in such form and under such conditions as the
Administrator may deem necessary or advisable; and 
 (xi) to construe and interpret the terms of the Plan and awards granted pursuant to
the Plan. 
 (c) Effect of Administrator’s Decision. All decisions, determinations and interpretations of the Administrator shall
be final and binding on all Optionees. 
  

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 5. Eligibility. 
 (a) Nonstatutory Stock Options may be granted to Service Providers. Incentive Stock Options may be granted only to Employees. 
 (b) Each Option shall be designated in the Option Agreement as either an Incentive Stock Option or a Nonstatutory Stock Option. However, notwithstanding such designation, to the extent that the aggregate Fair Market
Value of the Shares with respect to which Incentive Stock Options are exercisable for the first time by the Optionee during any calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds $100,000, such Options shall be
treated as Nonstatutory Stock Options. For purposes of this Section 5(b), Incentive Stock Options shall be taken into account in the order in which they were granted. The Fair Market Value of the Shares shall be determined as of the time the
Option with respect to the Shares is granted. 
 (c) Neither the Plan nor any Option shall confer upon any Optionee any right with respect to
continuing the Optionee’s relationship as a Service Provider with the Company, nor shall it interfere in any way with his or her right or the Company’s right to terminate such relationship at any time, with or without cause. 
 6. Term of Plan. Subject to Section 18 of the Plan, the Plan shall become effective upon its adoption by the Board. It shall continue in
effect until terminated under Section 14 of the Plan. 
 7. Term of Option. The term of each Option shall be stated in the Option
Agreement; provided, however, that the term shall be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to an Optionee who, at the time the Option is granted, owns stock
representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Option shall be five (5) years from the date of grant or such shorter term as may be provided
in the Option Agreement. 
 8. Option Exercise Price and Consideration. 
 (a) The per share exercise price for the Shares to be issued upon exercise of an Option shall be such price as is determined by the Administrator, but
shall be subject to the following: 
 (i) In the case of an Incentive Stock Option 
 (A) granted to an Employee who, at the time of grant of such Option, owns stock representing more than ten percent (10%) of the voting power of all
classes of stock of the Company or any Parent or Subsidiary, the exercise price shall be no less than 110% of the Fair Market Value per Share on the date of grant. 
 (B) granted to any other Employee, the per Share exercise price shall be no less than 100% of the Fair Market Value per Share on the date of grant. 
 (ii) In the case of a Nonstatutory Stock Option, the per Share exercise price shall be determined by the Administrator. 
 (iii) Notwithstanding the foregoing, Options may be granted with a per Share exercise price other than as required above pursuant to a merger or other
corporate transaction. 
 (b) The consideration to be paid for the Shares to be issued upon exercise of an Option, including the method of
payment, shall be determined by the Administrator (and, in the case of an Incentive Stock Option, shall be determined at the time of grant). Such consideration may consist of (i) cash, (ii) check, (iii)

  

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promissory note, (iv) other Shares which (A) in the case of Shares acquired upon exercise of an Option, have been owned by the Optionee for more
than six months on the date of surrender, and (B) have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the Shares as to which such Option shall be exercised, (v) consideration received by the Company
under a cashless exercise program implemented by the Company in connection with the Plan, or (vi) any combination of the foregoing methods of payment. In making its determination as to the type of consideration to accept, the Administrator
shall consider if acceptance of such consideration may be reasonably expected to benefit the Company. 
 9. Exercise of Option.

 (a) Procedure for Exercise; Rights as a Shareholder. Any Option granted hereunder shall be exercisable according to the terms hereof
at such times and under such conditions as determined by the Administrator and set forth in the Option Agreement. Unless otherwise determined by the Administrator, the Option shall become exercisable as follows: as to 25% of the Option Shares
subject to the Option, on the one year anniversary of the date of grant and the balance in 36 equal monthly installments commencing one month after such one year anniversary. Unless the Administrator provides otherwise, vesting of Options granted
hereunder shall be tolled during any unpaid leave of absence. An Option may not be exercised for a fraction of a Share. 
 An Option shall
be deemed exercised when the Company receives: (i) written or electronic notice of exercise (in accordance with the Option Agreement) from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to
which the Option is exercised. Full payment may consist of any consideration and method of payment authorized by the Administrator and permitted by the Option Agreement and the Plan. Shares issued upon exercise of an Option shall be issued in the
name of the Optionee or, if requested by the Optionee, in the name of the Optionee and his or her spouse. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the
Company), no right to vote or receive dividends or any other rights as a shareholder shall exist with respect to the Shares, notwithstanding the exercise of the Option. The Company shall issue (or cause to be issued) such Shares promptly after the
Option is exercised. No adjustment will be made for a dividend or other right for which the record date is prior to the date the Shares are issued, except as provided in Section 12 of the Plan. 
 Exercise of an Option in any manner shall result in a decrease in the number of Shares thereafter available, both for purposes of the Plan and for sale
under the Option, by the number of Shares as to which the Option is exercised. 
 (b) Termination of Relationship as a Service
Provider. If an Optionee ceases to be a Service Provider, such Optionee may exercise his or her Option within such period of time as is specified in the Option Agreement to the extent that the Option is vested on the date of termination (but in
no event later than the expiration of the term of the Option as set forth in the Option Agreement). In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for thirty (30) days following the
Optionee’s termination. If, on the date of termination, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not
exercise his or her Option within the time specified by the Administrator, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
 (c) Disability of Optionee. If an Optionee ceases to be a Service Provider as a result of the Optionee’s total and permanent disability, as defined in Section 22(e)(3) of the Code, the Optionee may
exercise his or her Option within such period of time as is specified in the Option Agreement to the extent the Option is vested on the date of termination (but in no event later than the expiration of the term of such Option as set forth in the
Option Agreement). In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for twenty-four (24) months following the Optionee’s termination. If, on the date of termination, the Optionee is not vested
as to his or her entire Option, the Shares covered by the unvested portion of the Option shall revert to the Plan. If, after termination, the Optionee does not exercise his or her Option within the time specified herein, the Option shall terminate,
and the Shares covered by such Option shall revert to the Plan. 
  

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 (d) Death of Optionee. If an Optionee dies while a Service Provider, the Option may be exercised
within such period of time as is specified in the Option Agreement (but in no event later than the expiration of the term of such Option as set forth in the Option Agreement), by the Optionee’s estate or by a person who acquires the right to
exercise the Option by bequest or inheritance, but only to the extent that the Option is vested on the date of death. In the absence of a specified time in the Option Agreement, the Option shall remain exercisable for twenty-four (24) months
following the Option’s termination. If, at the time of death, the Optionee is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option shall immediately revert to the Plan. The Option may be exercised
by the executor or administrator of the Optionee’s estate or, if none, by the person(s) entitled to exercise the Option under the Optionee’s will or the laws of descent or distribution. If the Option is not so exercised within the time
specified herein, the Option shall terminate, and the Shares covered by such Option shall revert to the Plan. 
 (e) Buyout
Provisions. The Administrator may at any time offer to buy out for a payment in cash or Shares, an Option previously granted, based on such terms and conditions as the Administrator shall establish and communicate to the Optionee at the time
that such offer is made. 
 10. First Refusal Rights. Each Option Agreement shall contain a provision that in the event an Optionee,
at any time, or from time to time, after exercise of his or her Option, receives a bona fide offer from any person or entity to purchase any of the Shares received upon exercise (the “Third Party Offer”), prior to the acceptance
thereof, the Optionee shall give written notice thereof to the Company. Such notice (the “Offering Notice”) shall contain a copy of the Third Party Offer and state the name and address of the offeror and the price at which and terms upon
which such Shares (the “Offered Shares”) are proposed to be transferred. The Offering Notice shall be deemed to be an offer by the Optionee to sell the Offered Shares, and for a period of 30 calendar days thereafter the Company shall have
the first right to purchase the Offered Shares at the price and upon the other terms stated in the Offering Notice. An acceptance of Offered Shares shall be effected by written notice (an “Acceptance Notice”) delivered to the Optionee. The
closing of the sale of the Offered Shares pursuant to the exercise of the Company’s rights hereunder shall occur within 30 calendar days after the date of the Acceptance Notice. The rights and obligations set forth in this Section 10 shall
terminate on the effective date of an IPO. 
 11. Non-Transferability of Options. Unless determined otherwise by the Administrator,
Options may not be sold, pledged, assigned, hypothecated, transferred or disposed of in any manner other than by will or by the laws of descent or distribution and may be exercised, during the lifetime of the Optionee, only by the Optionee. If the
Administrator makes an Option transferable, such Option shall contain such additional terms and conditions as the Administrator deems appropriate. 
 12. Adjustments Upon Changes in Capitalization, Merger or Asset Sale. 
 (a) Changes in Capitalization. Subject to any
required action by the stockholders of the Company, (i) the number of Option Shares and price per Option Share, (ii) the number of shares of Common Stock which have been authorized for issuance under the Plan but as to which no Options
have yet been granted, or (iii) the number of shares of Common Stock which have been returned to the Plan upon cancellation or expiration of an Option, shall be proportionately adjusted for any increase or decrease in the number of issued
shares of Common Stock resulting from a stock split, reverse stock split, stock dividend, combination or reclassification of the Common Stock, or any other increase or decrease in the number of issued shares of Common Stock effected without receipt
of consideration by the Company. The conversion of any convertible securities of the Company shall not be deemed to have been “effected without receipt of consideration.” Such adjustment shall be made by the Board, whose determination in
that respect shall be final, binding and conclusive. Except as expressly provided herein, no issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by
reason thereof shall be made with respect to, the number or price of Option Shares. 
  

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 (b) Dissolution or Liquidation. In the event of the proposed dissolution or liquidation of the
Company, the Administrator shall notify each Optionee as soon as practicable prior to the effective date of such proposed transaction. The Administrator in its discretion may provide for an Optionee to have the right to exercise his or her Option
until fifteen (15) days prior to such transaction as to all of the Option Shares covered thereby, including Shares as to which the Option would not otherwise be exercisable. In addition, the Administrator may provide that any Company repurchase
option applicable to any Shares purchased upon the exercise of an Option shall lapse as to all such Shares, provided the proposed dissolution or liquidation takes place at the time and in the manner contemplated. To the extent it has not been
previously exercised, an Option will terminate immediately prior to the consummation of such proposed dissolution or liquidation. 
 (c)
Merger or Asset Sale. In the event of a merger of the Company with or into another corporation, or the sale of substantially all of the assets of the Company, each outstanding Option shall be assumed or an equivalent option or right
substituted by the successor corporation or a Parent or Subsidiary of the successor corporation. In the event that the successor corporation refuses to assume or substitute for the Option, unless the Option Agreement provides otherwise, the Optionee
shall fully vest in and have the right to exercise his or her Option as to all of the Option Shares, including Shares as to which he or she would not otherwise be vested or exercisable. If an Option becomes fully vested and exercisable in lieu of
assumption or substitution in the event of a merger or sale of assets, the Administrator shall notify the Optionee in writing or electronically that the Option shall be fully exercisable for a period of fifteen (15) days from the date of such
notice, and the Option shall terminate upon the expiration of such period. For the purposes of this paragraph, the Option shall be considered assumed if, following the merger or sale of assets, the consideration (whether stock, cash or other
securities or property) received in the merger or sale of assets by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered a choice of consideration, the type of consideration chosen by the
holders of a majority of the outstanding Shares) is also received by Optionees for each Option Share held on the effective date of the transaction; provided, however, that if such consideration received in the merger or sale of assets
is not solely common stock of the successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide that the consideration to be received upon the exercise of an Option, for each Option Share, be
solely common stock of the successor corporation or its Parent equal in fair market value to the per share consideration received by holders of Common Stock in the merger or sale of assets. 
 (d) Termination After Change of Control. If an Employee’s employment with the Company is terminated by the Company without Cause within six
months after the effective date of a Change in Control, unless the Option Agreement provides otherwise, the Optionee shall automatically vest in and have the right to fully exercise his or her Option as to all of the Option Shares including without
limitation all Option Shares which have not yet become exercisable as of the date of termination of employment. 
 13. Timing of Granting
of Options. The date of grant of an Option shall, for all purposes, be the date determined by the Administrator. Notice of the determination shall be given to each Service Provider to whom an Option is so granted within a reasonable time after
the date of such grant. 
 14. Amendment and Termination of the Plan. 
 (a) Amendment and Termination. The Board may at any time amend, alter, suspend or terminate the Plan. 
 (b) Shareholder Approval. The Board shall obtain shareholder approval of any Plan amendment to the extent necessary and desirable to comply with
Applicable Laws. 
  

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 (c) Effect of Amendment or Termination. No amendment, alteration, suspension or termination of the
Plan shall impair the rights of any Optionee, unless mutually agreed otherwise between the Optionee and the Administrator, which agreement must be in writing and signed by the Optionee and the Company. Termination of the Plan shall not affect the
Administrator’s ability to exercise the powers granted to it hereunder with respect to Options granted under the Plan prior to the date of such termination. 
 15. Conditions Upon Issuance of Shares. 
 (a) Legal Compliance. Shares shall not be issued
pursuant to the exercise of an Option unless the exercise of such Option and the issuance and delivery of such Shares shall comply with Applicable Laws and shall be further subject to the approval of counsel for the Company with respect to such
compliance. 
 (b) Investment Representations. As a condition to the exercise of an Option, the Administrator may require the person
exercising such Option to represent and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares if, in the opinion of counsel for the
Company, such representation is required. 
 16. Inability to Obtain Authority. The inability of the Company to obtain authority from
any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary for the lawful issuance and sale of any Shares hereunder, shall relieve the Company of any liability in respect of the failure to issue
or sell such Shares as to which such requisite authority shall not have been obtained. 
 17. Reservation of Shares. The Company,
during the term of this Plan, shall at all times reserve and keep available such number of Shares as shall be sufficient to satisfy the requirements of the Plan. 
 18. Shareholder Approval. The Plan shall be subject to approval by the shareholders of the Company within twelve (12) months after the date the Plan is adopted. Such shareholder approval shall be obtained
in the degree and manner required under Applicable Laws. 
  

 9Form of Medidata Solutions, Inc. Amended and Restated 2000 Stock Option Plan

 Exhibit 10.4 
 MEDIDATA SOLUTIONS, INC. 
 AMENDED AND RESTATED 2000 STOCK OPTION PLAN 
 STOCK OPTION AGREEMENT 
 Unless
otherwise defined herein, the terms defined in the Amended and Restated 2000 Stock Option Plan, as amended (the “Plan”) of Medidata Solutions, Inc. (the “Company”) shall have the same defined meanings in this Stock Option
Agreement. 
  

	I.	NOTICE OF STOCK OPTION GRANT 

 Optionee:

 The undersigned Optionee has been granted an Option to purchase Common Stock of the Company, subject to the terms and conditions of the
Plan and this Option Agreement, as follows: 
  

									
	Date of Grant:	 		 		 	                    , 20    
				
	Vesting Commencement Date:	 		 		 	                    , 20    
					
	Exercise Price Per Share:	 		 	$	 	  
	  	
					
	Total Number of Options Granted:	 		 		 	  
	  	
					
	Total Exercise Price:	 		 	$	 	  
	  	
				
	Type of Option:	 	  
	 		 	Incentive Stock Option
				
		 	  
	 		 	Nonstatutory Stock Option
				
	Term/Expiration Date:	 		 		 	                    , 20    
					
	Vesting Schedule:	 		 		 		  	

 This Option shall be exercisable, in whole or in part, according to the following vesting
schedule: 
     % of the shares of Common Stock subject to the Option (the “Shares”) shall vest on the Vesting
Commencement Date, and the remaining     % of the Shares subject to the Option shall vest in
                             installments commencing
                             after such Vesting Commencement Date, subject to the Optionee’s continuing
to be a Service Provider on such dates. 
 Termination Period: 
 This Option shall be exercisable, to the extent this Option is vested on the date of termination, for three months after the Optionee ceases to be a Service Provider other than as a result of death or total and
permanent disability (as defined in Section 22(e)(3) of the Code). If the Optionee ceases to be a Service Provider as a result of death or total and permanent disability, this Option may be exercised, to the extent this Option is vested on the
date of termination, for one year after such Optionee ceases to be a Service Provider. In no event may the Optionee exercise this Option after the Term/Expiration Date as provided above. 

	II.	AGREEMENT 

 1. Grant of Option. The
Plan Administrator hereby grants to the Optionee named in the above Notice of Grant (the “Optionee”), an option (the “Option”) to purchase the number of Shares set forth in the Notice of Grant, at the exercise price per Share set
forth in the Notice of Grant (the “Exercise Price”), and subject to the terms and conditions of the Plan, which is incorporated herein by reference. Subject to Section 13(c) of the Plan, in the event of a conflict between the terms
and conditions of the Plan and this Option Agreement, the terms and conditions of the Plan shall prevail. This Option is intended to be an “incentive stock option” (“ISO”) within the meaning of Section 422 of the Internal
Revenue Code. The terms hereof will be construed and interpreted accordingly. The Option will be treated as a non-ISO to the limited extent, if at all, that the Option fails to qualify as an ISO. 
 2. Exercise of Option. 
 (a) Right
to Exercise. This Option shall be exercisable during its term in accordance with the Vesting Schedule set out in the Notice of Grant and within the applicable provisions of the Plan and this Option Agreement. 
 (b) Method of Exercise. This Option shall be exercisable by giving written notice to the Company, which notice shall state the election to
exercise the Option, the number of Shares with respect to which the Option is being exercised and such other representations and agreements as may be required by the Company. Such notice shall be accompanied by payment of the aggregate Exercise
Price as to all exercised Shares. This Option shall be deemed to be exercised upon receipt by the Company of such fully executed notice accompanied by the aggregate Exercise Price. 
 No Shares shall be issued pursuant to the exercise of an Option unless such issuance and such exercise complies with Applicable Laws. Assuming such
compliance, for income tax purposes the Shares shall be considered transferred to the Optionee on the date on which the Option is exercised with respect to such Shares. 
 3. Optionee’s Representations. In the event the Shares have not been registered under the Securities Act of 1933, as amended (the “Securities Act”), at the time this Option is exercised, the
Optionee shall, if required by the Company, concurrently with the exercise of all or any portion of this Option, deliver to the Company his or her Investment Representation Statement in the form attached hereto as Exhibit A. 
 4. Lock-Up Period. The Optionee hereby agrees that, if so requested by the Company or any representative of the underwriters (the “Managing
Underwriter”) in connection with any registration of the offering of any securities of the Company under the Securities Act, the Optionee shall not sell or otherwise transfer any Shares or other securities of the Company during the 180-day
period (or such other period as may be requested in writing by the Managing Underwriter and agreed to in writing by the Company) (the “Market Standoff Period”) following the effective date of a registration statement of the Company filed
under the Securities Act. Such restriction shall apply only to the first registration statement of the Company to become effective under the Securities Act that includes securities to be sold on behalf of the Company to the public in an underwritten
public offering under the Securities Act. The Company may impose stop-transfer instructions with respect to securities subject to the foregoing restrictions until the end of such Market Standoff Period. 
 5. Method of Payment. Payment of the aggregate Exercise Price shall be by any of the following, or a combination thereof, at the election of the
Optionee: 
 (a) cash or check; or 
 (b) consideration received by the Company under a formal cashless exercise program adopted by the Company in connection with the Plan. 
 6. Restrictions on Exercise. This Option may not be exercised until such time as the Plan has been approved by the stockholders of the Company, or if the issuance of such Shares upon such exercise or the method of payment of
consideration for such Shares would constitute a violation of Applicable Law. 
  

 2 

 7. Non-Transferability of Option. This Option may not be assigned or transferred in any manner
other than by will or by the laws of descent or distribution and may be exercised during the lifetime of the Optionee only by the Optionee. The terms of the Plan and this Option Agreement shall be binding upon the executors, administrators, heirs,
successors and assigns of the Optionee. 
 8. Term/Expiration Date of Option. This Option may be exercised only prior to the
Term/Expiration Date set out in the Notice of Grant, and may be exercised during such term only in accordance with the Plan and the terms of this Option. 
 9. Stockholders Agreement. As a condition of exercise of this Option, the Optionee agrees that, if requested by the Company prior to an initial public offering of the Company’s equity securities, the
Optionee (or other person exercising this Option after the Optionee’s death) shall become a party to the Second Amended and Restated Stockholders Agreement dated as of May 27, 2004, by and among the Company and certain stockholders of the
Company, as it may be amended from time to time, or any subsequent stockholders agreement by and among the Company and its stockholders (the “Stockholders Agreement”). The Optionee hereby acknowledges that, unless and until any such
Stockholders Agreement requested by the Company is executed by the Optionee (or such other person exercising the Option after the Optionee’s death), the Company shall have no obligation to issue or deliver any shares of Common Stock upon
exercise of this Option. 
 10. No Guarantee of Continued Service. THE OPTIONEE ACKNOWLEDGES AND AGREES THAT THE VESTING OF SHARES
PURSUANT TO THE VESTING SCHEDULE HEREOF IS EARNED ONLY BY CONTINUING AS A SERVICE PROVIDER AT THE WILL OF THE COMPANY (NOT THROUGH THE ACT OF BEING HIRED, BEING GRANTED THIS OPTION OR ACQUIRING SHARES HEREUNDER). THE OPTIONEE FURTHER ACKNOWLEDGES
AND AGREES THAT THIS AGREEMENT, THE TRANSACTIONS CONTEMPLATED HEREUNDER AND THE VESTING SCHEDULE SET FORTH HEREIN DO NOT CONSTITUTE AN EXPRESS OR IMPLIED PROMISE OF CONTINUED ENGAGEMENT AS A SERVICE PROVIDER FOR THE VESTING PERIOD, FOR ANY PERIOD,
OR AT ALL, AND SHALL NOT INTERFERE IN ANY WAY WITH THE OPTIONEE’S RIGHT OR THE COMPANY’S RIGHT TO TERMINATE THE OPTIONEE’S ENGAGEMENT AS A SERVICE PROVIDER AT ANY TIME, WITH OR WITHOUT CAUSE. 
 The Optionee acknowledges receipt of a copy of the Plan and represents that he or she is familiar with the terms and provisions thereof, and hereby
accepts this Option subject to all of the terms and provisions thereof. The Optionee has reviewed the Plan and this Option in their entirety, has had an opportunity to obtain the advice of counsel prior to executing this Option and fully understands
all provisions of the Option. The Optionee hereby agrees to accept as binding, conclusive and final all decisions or interpretations of the Administrator upon any questions arising under the Plan or this Option. The Optionee further agrees to notify
the Company upon any change in the residence address indicated below. 
  

							
	OPTIONEE	  		 	MEDIDATA SOLUTIONS, INC.
				
	Signature:	 	  
	  	By:	 	  

	Print Name:	 	  
	  		 	Tarek Sherif, Chairman & Chief Executive Officer
	Residence Address:	  		 	
	  
	  		 	
	  
	  		 	
	  
	  		 	

  

 3 

 EXHIBIT A            FORM OF
INVESTMENT REPRESENTATION STATEMENT 
 To the Board of Directors of 
 Medidata Solutions, Inc.: 
 In accordance with that certain stock option agreement between the undersigned and Medidata Solutions,
Inc., a Delaware corporation (the “Company”) dated                         (“Option Agreement”) and in
accordance with the Medidata Solutions Inc. Amended and Restated 2000 Stock Option Plan, as amended (hereinafter, the “Plan”) under which I was awarded
                    stock options, each to purchase one (1) share of the Company’s common stock at an exercise price of
$                per share, I hereby make the following investment representations to the Company in connection with my exercise of options: 
 (a) The undersigned is a bona fide resident of the state contained in the address set forth on the signature page of the Option Agreement. 
 (b) The undersigned has received, read carefully and is familiar with the Plan; has had a reasonable opportunity to ask questions of the Company and its
representatives concerning the Company’s business and affairs; and the Company has answered all inquiries that the undersigned or the undersigned’s representatives have put to it concerning the Company’s business and affairs and the
exercise of my options. The undersigned has had access to all additional information necessary to verify the accuracy of the information set forth in the Plan, and other information provided to me by the Company’s representatives and has taken
all the steps necessary to evaluate the merits and risks of an investment, resulting from the exercise of options awarded to me under the Plan. 
 (c) The undersigned has such knowledge and experience in finance, securities, investments and other business matters so as to be able to protect the interests of the undersigned concerning the exercise of my options, and the
undersigned’s investment in the Company resulting from the exercise of the options is not material when compared to the undersigned’s total capacity. The undersigned understands and expressly acknowledges that an investment in the Company
as a result of the exercise of the options is of a speculative nature involving a high degree of risk, and may result in the entire loss of the aggregate exercise price of the options. 
 (d) The undersigned acknowledges that no market for shares of the Company’s common stock presently exists and it is unlikely that one will develop
in the future, and that the undersigned may find it impossible to liquidate the resulting investment in the Company from the exercise of the options at a time when the undersigned may desire to do so, or at any other time. 
 (e) The undersigned is aware that the shares of the Company’s common stock issuable upon the exercise of the options have not been registered under
the Securities Act of 1933, as amended (the “Act”), in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the Optionee’s investment intent as expressed herein. The
undersigned acknowledges that it has been informed by the Company, or is otherwise familiar with, the nature of the limitations imposed by the Act and the rules and regulations thereunder on the transfer of securities. In particular, the undersigned
agrees that no sale, assignment or transfer of any shares of the Company’s common stock issuable upon the exercise of the options will be valid or effective, and the Company shall not be required to give any effect to such sale, assignment or
transfer, unless (i) such sale, assignment or transfer is registered under the Act, it being understood that the shares of the Company’s common stock to be issued upon the exercise of the options are not currently registered for sale and
that the Company has no obligation or intention to so register the shares issuable upon the exercise of the options, or (ii) such shares that are to be issued upon the exercise of the options are sold, assigned or transferred in accordance with
all the requirements and limitations of Rule 144 under the Act, it being understood that Rule 144 is not available at the present time, or (iii) such sale, assignment or transfer is otherwise exempt from the registration requirements under the
Act. The undersigned further understands that an opinion of counsel and other documents may be required to transfer the shares issuable upon the exercise of the options. The undersigned acknowledges that the certificates evidencing the shares
issuable upon the exercise of the options will all bear the following, or a substantially similar legend, and such other legends as may be required by state blue sky laws: 
 “The securities represented by this certificate have not been registered under the Securities Act of 1933 (the “Act”), or any state securities laws and neither such securities nor any interest therein
may be offered, sold, pledged, assigned or otherwise transferred unless (1) a registration statement with respect thereto is effective under the Act and any applicable state securities laws, or (2) the Company receives an opinion of
counsel to the holder of such securities, which counsel and opinion are reasonably satisfactory to the Company, that such securities may be offered, sold, pledged, assigned or transferred in the manner contemplated without an effective registration
statement under the Act or applicable state securities laws.” 

 (f) The undersigned is acquiring the shares of the Company’s common stock issuable upon the exercise
of the options for the undersigned’s own account for investment purposes only and not with a view to the sale or distribution thereof or the granting of any participation interest therein, and the undersigned has no present intention of
distributing or selling to others any of such interest or granting participations therein. 
 (g) The undersigned is not relying on the
Company with respect to the tax and other economic considerations of an investment in the shares of the Company’s common stock issuable upon the exercise of the options. 
  

					
	 Dated:

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