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EXHIBIT 10.36    
    

        December 12, 2005        

Mr. Richard
C. ("Bink") Garrison

337 Marlborough Street, Apt. 3

Boston, MA 02115 

	RE:
	Vertex
Pharmaceuticals Incorporated

Change of Control Agreement 

Dear
Bink: 

Your
expertise, reputation and position will make you a key member of the senior management team of Vertex Pharmaceuticals Incorporated (the "Company"). As a result, the Company would like to provide
you with the following "change of control" benefit to help ensure that in the event the Company becomes involved in a "change of control" transaction, there will be no distraction from your attention
to the needs of the Company. 

	I.
	Definitions. For the purposes of this Agreement, capitalized terms shall have the following meaning:

	1.
	"Base Salary" shall mean your annual base salary in effect immediately prior to a Change of Control (as such term is defined in
Section I.4 below).

	2.
	"Cause" shall mean:

	(e)
	your
conviction of a felony crime of moral turpitude;

	(f)
	your
willful refusal or failure to follow a lawful directive or instruction of the Company's Board of Directors or the individual(s) to whom you report, provided that you receive
prior written notice of the directive(s) or instruction(s) that you failed to follow, and provided further that the Company, in good faith, gives you thirty (30) days to correct any problems
and further provided if you correct the problem(s) you may not be terminated for Cause in that instance;

	(g)
	in
carrying out your duties you commit (i) willful gross negligence, or (ii) willful gross misconduct, resulting in either case in material harm to the Company, unless
such act, or failure to act, was believed by you, in good faith, to be in the best interests of the Company; or

	(h)
	your
violation of the Company's policies made known to you regarding confidentiality, securities trading or inside information.

	3.
	"Change of Control" shall mean that:

	(a)
	any
"person" or "group" as such terms are used in Sections 13(d) and 14(d)(2) of the Securities Exchange Act of 1934 (the"Act"), becomes a beneficial owner, as such term is used in
Rule 13d-3 promulgated under the Act, of securities of the Company representing more than fifty percent (50%) of the combined voting power of the outstanding securities of the
Company, as the case may be, having the right to vote in the election of directors; or 

all
or substantially all the business or assets of the Company are sold or disposed of, or the Company or a subsidiary of the Company combines with another company pursuant to a merger, consolidation,
or other similar transaction, other than (i) a transaction solely for the purpose of reincorporating the Company or one of its subsidiaries in a different jurisdiction or recapitalizing or
reclassifying the Company's stock; or (ii) a merger or consolidation in which the shareholders of the Company immediately prior to such merger or consolidation continue to own at least a
majority of the outstanding voting 

securities
of the Company or the surviving entity immediately after the merger or consolidation. 

	4.
	"Disability" shall mean a disability as determined under the Company's long-term disability plan or program in effect at the
time the disability first occurs, or if no such plan or program exists at the time of disability, then a "disability" as defined under Internal Revenue Code Section 22(e)(3).

	5.
	"Good Reason" shall mean that within ninety (90) days prior to a Change of Control, or within twelve (12) months after a
Change of Control, one of the following events occurs without your consent:

	(a)
	You
are assigned to material duties or responsibilities that are inconsistent, in any significant respect, with the scope of duties and responsibilities associated with your position
and office immediately prior to the Change of Control (provided that such reassignment of duties or responsibilities is not for Cause, due to your Disability or at your request);

	(b)
	You
suffer a material reduction in the authorities, duties, or job title and responsibilities associated with your position and office immediately prior to the Change of Control, on
the basis of which you make a good faith determination that you can no longer carry out your position or office in the manner contemplated before the Change of Control
(provided that such reduction in the authorities, duties, or job title and responsibilities is not for Cause, due to your Disability or at your
request);

	(c)
	your
annual base salary is decreased below the Base Salary;

	(d)
	the
principal offices of the Company, or the location of the office to which you are assigned at the time this Agreement is entered into, is relocated to a place
thirty-five (35) or more miles away, without your agreement; or

	(e)
	following
a Change of Control, the Company's successor fails to assume the Company's rights and obligations under this Agreement.

	6.
	"Termination Date" shall mean the last day of your employment with the Company.

	II.
	Severance Benefits upon Change of Control. In the event your employment is terminated
(except for termination for Cause or due to a Disability) within ninety (90) days prior to a Change of Control or within twelve
(12) months after a Change of Control; or if you, of your own initiative, terminate your employment within ninety (90) days prior to a Change of Control or within twelve
(12) months after a Change of Control for Good Reason, in exchange for a general release of all claims, you shall receive the following benefits:

	1.
	Severance Payment—The Company shall make a lump sum payment to you equal to:

	(a)
	Your
annual Base Salary (provided, however, that in the event you terminate your employment for Good Reason based on a reduction in
Base Salary, then the base salary to be used in calculating the Severance Payment shall be the base salary in effect immediately prior to such reduction in Base Salary); and

	(b)
	any
unpaid portion of a bonus award actually awarded but not yet paid to you under any bonus program applicable to the Company's senior executives and in effect prior to the Change of
Control, pro rated in the event the Termination Date is prior to the end of the bonus plan year. 

The
Severance Payment shall be made in cash within ten (10) days of the execution of a general release and expiration without revocation of any applicable revocation periods under the general
release. 

	2.
	Accelerated Vesting—Stock options for the purchase of the Company's securities held by you as of the Termination Date and
not then exercisable shall be deemed to have been held by you 

for
an additional 18-months, for purposes of calculating the number of options which are exercisable on the Termination Date. The options to which this accelerated vesting applies shall
remain exercisable until the earlier of (a) the end of the 90-day period immediately following the Termination Date, or (b) the date the stock option(s) would otherwise
expire. 

	3.
	Continued Insurance Coverage—If COBRA coverage is elected by you, the Company shall pay the cost of COBRA continuation
premiums on your behalf to continue standard medical, dental and life insurance coverage for you (or the cash equivalent of same in the event you are ineligible for continued coverage) for a period of
18-months from the Termination Date. 

You
shall not be required to mitigate the amount of the Severance Payment or any other benefit provide under this Agreement by seeking other employment or otherwise, nor shall the amount of any
payment or benefit provided for in this Agreement be reduced by any compensation earned by you as the result of other employment, by retirement benefits, or by offset against any amount claimed to be
owed by you to the Company or otherwise. 

	III.
	Miscellaneous. 
	1.
	Employee's Obligations. Upon the termination of employment, you shall promptly deliver to the Company all property of the Company and
all material documents, statistics, account records, programs and other similar tangible items which may be in your possession or under your control and which relate in a material way to the business
or affairs of the Company or its subsidiaries, and no copies of any such documents or any part thereof shall be retained by you.

	2.
	Entire Agreement. This Agreement, the "Employee Non-Disclosure, Non-Competition &
Inventions Agreement" executed by you and the Company effective as of December 12, 2005 and the offer letter previously signed by you and the Company, cover the entire
understanding of the parties as to your rights and obligations in the event of a Change of Control, superseding all prior understandings and agreements related thereto. No modification or amendment of
the terms and conditions of this Agreement shall be effective unless in writing and signed by the parties or their respective duly authorized agents.

	3.
	Governing Law. This Agreement shall be governed by the laws of the Commonwealth of Massachusetts, as applied to contracts entered into
and performed entirely in Massachusetts by Massachusetts residents.

	4.
	Successors and Assigns. This Agreement may be assigned by the Company upon a sale, transfer or reorganization of the Company. This
Agreement shall be binding upon and inure to the benefit of the parties hereto and their successors, permitted assigns, legal representatives and heirs. 

Kindly
indicate your acceptance of the forgoing by signing and dating this Agreement as noted below, and returning one fully executed original to my attention. 

	 	 	 	 	Very truly yours,
	

 	
 	

 	
 	
Vertex Pharmaceuticals Incorporated
	

 	
 	

 	
 	

By:	
 	

/s/  KENNETH S. BOGER      
 Kenneth S. Boger

Sr. Vice President and General Counsel
	

ACCEPTED AND AGREED:	
 	

 	
 	

 
	

/s/  RICHARD C. GARRISON      
 Richard C. Garrison	
 	

 	
 	

 	
 	

 
	December 12, 2005	 	 	 	 	 	 

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EXHIBIT 10.37    
    

        December 12, 2005        

Mr. Richard
C. ("Bink") Garrison

337 Marlborough Street, Apt. 3

Boston, MA 02115 

	Re:
	Amendment
to Change of Control Agreement 

Dear
Bink: 

        The
Change of Control Agreement dated as of December 12, 2005 between you and Vertex Pharmaceuticals Incorporated (the "Agreement")
hereby is amended, effective as of the date set forth above, as follows: 

	1.
	Insert
a new Section I.7, which shall state in its entirety:

	I.7
	"Pro-Rata Share of Restricted Stock" shall mean, for any grant of restricted stock as to which the Company's repurchase
right lapses ratably over a specified period (e.g. in equal annual increments over four years), that number of shares as to which the Company's repurchase right with respect to those shares would have
lapsed if the Executive's employment by the Company had continued an additional 18 month period. For any other shares of restricted stock, "Pro-Rata Share of Restricted Stock" shall
mean, as to any shares of restricted stock which were granted on the same date and as to which the Company's repurchase right lapses on the same date, that portion of such shares calculated by
multiplying the number of shares by a fraction, the numerator of which is the number of days that have passed since the date of grant, plus the number of days in 18 months, and the denominator
of which is the total number of days from the date of the grant until the date (without regard to any provisions for earlier vesting upon achievement of a specified goal) on which the Company's
repurchase right would lapse under the terms of the grant.

	2.
	Delete
Section 2, "Accelerated Vesting," in its entirety, and substitute the following therefor:

	2.
	Accelerated Vesting

	(a)
	Stock
options for the purchase of the Company's securities held by you as of the Termination Date and not then exercisable shall be deemed to have been held by you for an additional
18 months, for purposes of calculating the number of options which are exercisable on the Termination Date. The options to which this accelerated vesting applies shall remain exercisable until
the earlier of (a) the end of the 90-day period immediately following the Termination Date, or (b) the date the stock option(s) would otherwise expire; and

	(b)
	the
Company's lapsing repurchase right with respect to shares of restricted stock held by you shall lapse with respect to the Pro-Rata Share of Restricted Stock.

	(c)
	Notwithstanding
anything to the contrary in this agreement, the terms of any option agreement or restricted stock agreement shall govern the acceleration, if any, of vesting or
lapsing of the Company's repurchase rights, as applicable, except to the extent that the terms of this agreement are more favorable to you. 

        As
so amended, the Change of Control Agreement shall remain in full force and effect. 

        If
you agree to the foregoing amendment, please so indicate by signing and returning the enclosed copy of this letter. 

	 	 	 	 	Vertex Pharmaceuticals Incorporated
	

 	
 	

 	
 	

By:	
 	

/s/  KENNETH S. BOGER      
 Kenneth S. Boger

Senior Vice President and General Counsel
	

Accepted and Agreed:	
 	

 	
 	

 
	

/s/  RICHARD C. GARRISON      
 Richard C. Garrison	
 	

 	
 	

 	
 	

 

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EXHIBIT 10.37

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