Document:

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                                                                   EXHIBIT 10.41

                        HUNTER WISE FINANCIAL GROUP - LLC

September 26, 2000

Joseph M. Cummins, CEO
Amarillo Biosciences, Inc.
800 West Ninth Ave.
Amarillo, Texas 79101-3206

Re:     Engagement Agreement

Dear Dr. Cummins:

This Engagement Agreement ("Agreement") defines the scope of services to be
provided by Hunter Wise Financial Group, LLC ("Hunter Wise") to Amarillo
Biosciences, Inc. its successors and/or affiliates (the "Company") as well as
the compensation to be paid by the Company to Hunter Wise in exchange.

1.0     ENGAGEMENT.

1.1     ADVISORY SERVICES. Hunter Wise will provide advisory services to the
Company in the areas of corporate development corporate finance and capital
placement transactions. Hunter Wise will assign a managing director to lead its
activities and act as primary interface with the company. Hunter Wise will also
introduce other firms, products and services to the Company as indicated during
the normal course of business and act as coordinator for all activities within
its purview. It is also understood that Hunter Wise is acting as an advisor
only, and shall have no authority to enter into any commitments on the Company's
behalf, or to negotiate the terms of any transaction, or to hold any funds or
securities in connection with any transaction or to perform any other acts on
behalf of the Company without the Company's express written consent.

1.2     TRANSACTIONS. During the course of the engagement period, it is
anticipated that the Company will choose to execute one or more corporate
development and/or corporate finance transactions. Hunter Wise will assist the
Company in executing these transactions on a best efforts basis, on terms
satisfactory and acceptable to the Company.

2.0     ENGAGEMENT TERMS.

2.1     PERIOD. The period of Hunter Wise's engagement (the "Engagement Period")
will expire upon the earlier to occur of (i) 12 months from the date we receive
an executed copy of the Agreement from the Company or (ii) the mutual written
agreement of the Company and Hunter Wise. The Engagement Period may be extended
for additional 6-month periods under the same terms and conditions as described
herein upon mutual consent of the Company and Hunter Wise.

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Notwithstanding the foregoing, Hunter Wise may at its sole option, terminate its
obligation hereunder without liability if, in the reasonable opinion of Hunter
Wise, a change has occurred in the Company's financial condition, results of
operations, properties, business prospects, or the composition of the Company's
management which, in Hunter Wise's sole determination has adversely affected the
Company's business.

2.2     EXCLUSIVITY. The company engages Hunter Wise on an exclusive basis. The
company shall not be permitted to engage any other firm or person as an
investment banker or other financial intermediary for the duration of this
engagement except Transition Partners representing Atrix. Notwithstanding any
other provisions of this Agreement if at any time during the 12 month period
following the end of the Engagement Period the Company completes a securities
transaction with an investor or potential investor introduced by Hunter Wise (or
an affiliate of any such entity), upon the closing of any such transaction
Hunter Wise will be paid the Compensation which would be due under section 3.0
hereof.

3.0     COMPENSATION.

Throughout the course of what Hunter Wise anticipates will be a long-term
relationship with the Company, Hunter Wise may perform a variety of services. No
compensation shall be due for funds received from Atrix Inc. or from existing
shareholders of the Company and/or their direct affiliates, including but not
limited to conversions by existing shareholders of debt to equity. In exchange
for these services Hunter Wise shall receive compensation as follows:

3.1     TRANSACTIONS. Any sale, merger, acquisition, joint venture, strategic
alliance, technology partnership, licensing agreement strategic purchasing,
agreement, taking private, or other similar agreements shall accrue compensation
to Hunter Wise under a standard "Lehman Formula" percentage fee of the Aggregate
Consideration calculated as follows:

        5.0% for Aggregate Consideration of less than $5,000,000, plus
        4.0% for Aggregate Consideration between $5,000,000 - $10,000,000, plus
        3.0% for Aggregate Consideration between $10,000,001 - $15,000,000, plus
        2.0% for Aggregate Consideration above $15,000,000

A minimum of $100,000 fee will be due for any transacdon falling under the
description defined above. "Aggregate Consideration" is defined as the greater
of the total amount actually payable or the value assigned to such a
transaction, whether due at Closing or deferred by the Company or any affiliate
of the Company, and shall include all cash or cash equivalents, the principal
amount of any notes, all classes of securities issued, the aggregate amounts
payable pursuant to any consulting agreements, employment agreements, agreements
not to complete and similar agreements, and the aggregate amount of value of any
bank or term loans or other debts assumed or refinanced as part of the
transaction.

3.2     CORPORATE FINANCE. All securities transactions for the benefit of the
Company will accrue compensation to Hunter Wise according to the corresponding
categories below:

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3.2.1   SECURED DEBT FINANCING. For any traditional financing (which includes
senior debt financing, revolving lines of credit, equipment lease financing,
purchase order financing, accounts receivable, or any other type of secured debt
financing), with the exception of any extension, expansion or revision of the
Company's existing credit facilities, Hunter Wise shall receive upon Closing: a
success fee, payable in cash, equal to one and one-half percent (1.5%) of the
gross proceeds received by the Company at each such Closing, and no warrants.

3.2.2   SUBORDINATED DEBT FINANCING. For any debt investment placed for the
Company (including mezzanine funding, notes, term loans, promissory notes,
debentures, etc.), with the exception of any extension, expansion or revision of
the Company's existing credit facilities, Hunter Wise shall receive upon
Closing: (i) a success fee, payable in cash, equal to three and on half percent
(3.5%) of the gross proceeds received by the Company at each such Closing; plus
(ii) warrants in the entity financed, with a cashless exercise provision, equal
to three and one-half percent (3.5%) of the gross proceeds received by the
Company at each such Closing; exercisable at a strike price equal to one hundred
percent (100%) of the fair market value price of the common stock for the
Company as of the date the Company receives the funds, in whole or in part, at
any time within 7 years from issuance.

3.2.3   EQUITY INVESTMENT. For any equity investment into the Company by a
financing source contact of Hunter Wise for which the Company receives funds
(including any common stock, preferred stock, convertible preferred stock,
convertible debentures, subordinated debt with warrants or any other securities
convertible into common stock), Hunter Wise shall receive upon Closing: (i) a
success fee, payable in cash, equal to seven percent (7%) of the gross amount to
be disbursed to the Company each said Closing plus (ii) warrants in the entity
financed, with a cashless exercise provision, equal to six percent (6%) of the
gross amount to be disbursed to the Company at each such Closing; exercisable at
a strike price equal to 100% of the fair market value price of the common stock
for the Company as of the date the Company receives the funds, in whole or in
part at any time within 7 years from issuance.

3.3     RETAINER. The Company will, simultaneously with delivery of this
executed Agreement to Hunter Wise, make a $25,000 non-refundable advance payment
to Hunter Wise. Upon a successful Closing, if any, such $25,000 will be deducted
from the success fee payable to Hunter Wise.

3.4     EXPENSES. In addition to any success fee payable to Hunter Wise herein,
the Company will reimburse Hunter Wise monthly for Hunter Wise's reasonable
direct out-of-pocket expenses incurred in connection with their services;
however all expenses in excess of $1000 shall be pre-approved.

3.5     FEE REDUCTIONS. Not withstanding any other provisions to the contrary
within this, section #3, if any of the companies listed in Exhibit "A" attached
hereto and made a part of the Agreement enter into a dual signed Letter of
Intent with the Company within 90 days of executing this Agreement the Success
Fee will be reduced by 50%; if within 120 days, 25%. After 120 days, there will
be no reduction.

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4.0     OTHER

4.1     OFFERING MATERIALS. Hunter Wise will use no offeiing materials other
than such materials approved by the Company. The Company agrees to use its best
efforts to approve and/or prepare, as necessary, any offering materials within
15 days from the date the Company advises Hunter Wise that it intends to execute
a financial transaction, in accordance with section 1.2 hereof.

4.2     CLOSING. Hunter Wise will assist with the closing of any transaction or
financing (the "Closing") which will occur through an escrow established with
City National Bank or other escrow agent designated by Hunter Wise and
reasonably acceptable to the Company.

4.3     CONFIDENTIALITY. This Agreement is for the confidential use of the
Company and Hunter Wise only and may not be disclosed by the Company to any
person other than its attorneys, accountants and financial advisors, and,only on
a confidential basis in connection with the proposed transaction or financing,
except where disclosure is required by law or is mutually consented to in
writing by Hunter Wise and the Company.

4.4     DISCLOSURE. During the Engagement Period and for sixty days thereafter,
the Company agrees not to issue any press releases or communications to the
public relating to the transactions or financings without Hunter Wise's prior
approval or unless otherwise required by law, which will not be unreasonably
withheld or delayed, and the Company agrees that such press release will state
that the transaction or financing was arranged by Hunter Wise, unless we
mutually agree otherwise or unless otherwise required by law. The Company
further agrees that Hunter Wise may, at its own expense, publicize its services
to the Company hereunder including, without limitation, issuing press releases,
placing advertisements and referring to the transaction or financing on Hunter
Wise's website.

4.5     PERFORMANCE. Notwithstanding any other provision of this Agreement,
nothing set forth herein shall be construed as a firm commitment to execute any
transaction or place the full amount of any offering or any minimum portion
thereof. Hunter Wise cannot guarantee the successful conclusion of any
transaction, for which the Company has the right to reject, for any reason, in
its sole and absolute discretion.

4.6     INDEMNIFICATION. The Company shall indemnify and hold harmless Hunter
Wise from and against all claims, damages, losses, and liabilities (including,
without limitation, reasonable attorneys' fees and expenses) arising out of or
based upon (i) any misstatement or omission or alleged misstatement or omission,
in any Company documentation or any other materials or information supplied or
approved by the Company which are disseminated by Hunter Wise to third parties,
including financing sources, or (ii) any agreement between the Company and any
financing source; except that the Company shall not be liable for any claim
damage, loss or liability which is finally determined to have resulted from
Hunter Wise's fraud, gross negligence or willful misconduct In any action where
indemnity applies, Hunter Wise shall be entitled to its own separate counsel at
the Company's expense. Neither termination nor completion of this Agreement
shall affect these

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indemnification provisions, which shall survive any such termination or
completion and remain operative and in full force and effect.

4.7     GOVERNING LAW/ARBITRATION. The terms of this Agreement will be governed
by and interpreted in accordance with the internal laws of the State of
California, without regard to the principles of conflict of laws. Any
controversy, dispute or claim between the parties relating to this Agreement
shall be resolved by binding arbitration in Orange County, California in
accordance with the rules of the American Arbitration Association. The parties
agree that in the event that any controversy, dispute or claim between the
parties relating to this Agreement is resolved by binding arbitration, the
prevailing party, if any, as determined by the arbitrators' award, shall be
entitled to reimbursement of all expenses incurred in the arbitration including
reasonable attorneys' fees; provided that in no, event shall the arbitrator have
the authority to award punitive damages. Judgment on the award may be entered in
any court having jurisdiction over the award.

4.8     MISCELLANEOUS. The Company undertakes and represents to Hunter Wise that
the number of shares necessary to fulfill any offerings will be available at
Closing, that the number of shares of common stock underlying the shares will be
available upon each conversion of the shares; that the shares of common stock
underlying the warrants will be available upon exercise of the warrants; and
that the Company will comply in all respects with the terms of each purchase
agreement and registration rights agreement entered into with the purchasers of
the shares.

If the foregoing is acceptable, please sign and return to Hunter Wise a copy of
this Agreement, which shall represent the entire agreement between us with
respect to the matters addressed herein. We look forward to working with and
remain,

Yours very truly,

Hunter Wise Financial Group, LLC

----------------------------------
Fred G. Jager
President

ACCEPTED AND AGREED TO THIS __ DAY OF ___________, 2000.

Amarillo Biosciences, Inc.

By:
    -----------------------------

Its:
     ----------------------------

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                       ADDENDUM "A"TO ENGAGEMENT AGREEMENT
                            DATED SEPTEMBER 26, 2000
                                 BY AND BETWEEN
                        HUNTER WISE FINANCIAL GROUP, LLC
                                       AND
                           AMARILLO BIOSCIENCES, INC.

        Antex
        Demegen
        MGI Pharma
        Biopharm and Middle Eastern investors introduced through Biopharm
        Crystaal/Biovail

                                        6<PAGE>   1
                                                                   EXHIBIT 10.42

                                SUPPLY AGREEMENT

                          ANHYDROUS CRYSTALLINE MALTOSE

      THIS AGREEMENT is made and effective this 13 day of October , 2000, by and
between AMARILLO BIOSCIENCES, INC., a Texas corporation with its principal place
of business at 800 West 9th, Amarillo, Texas 79101 (hereinafter "ABI") and
HAYASHIBARA BIOCHEMICAL LABORATORIES, INC. and HAYASHIBARA SHOJI, INC., each of
them with its principal place of business at 2-3, Shimoishii 1-chome, Okayama
700-0907, Japan (hereinafter collectively "Hayashibara"). ABI and Hayashibara
collectively referred to hereinafter as the "Parties".

      WHEREAS, Hayashibara desires to grant to ABI, and ABI desires to have, the
exclusive right to purchase and distribute Hayashibara's pharmaceutical grade
anhydrous crystalline maltose, subject to the specifications as attached
herewith (hereinafter "ACM"), for sale as an active ingredient in nutraceutical
products which are developed, produced and commercialized by ABI's proprietary
technology worldwide, except Japan.

      NOW, THEREFORE, for and in consideration of the mutual covenants contained
herein, Hayashibara and ABI agree as follows:

      Section 1. Right to Purchase and Distribute.

      Hayashibara hereby grants to ABI the exclusive right to purchase,
distribute and sell, worldwide except Japan, nutraceutical and health-care
products for human consumption containing ACM as an active ingredient to relieve
dry mouth (hereinafter the "Products").

      Section 2. Consideration.

      Hayashibara shall receive a transfer fee from ABI in the amount of (US)
**** Dollars ($****) per kilogram. f.o.b. Kobe, Japan.

      Section 3. Term.

      Unless sooner terminated as hereinafter provided, this Agreement shall
remain in effect for a period of Five (5) years from the date of this Agreement.
After that initial term, the Agreement shall be automatically renewed for
successive One (1) year term unless one of the Parties gives written notice of
termination or modification of this Agreement to the other within Thirty (30)
days prior to commencement of the renewal term. Any termination pursuant to this
paragraph shall not relieve Hayashibara of any obligation to fill purchase
orders placed with Hayashibara prior to termination. Similarly such termination
shall not

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

<PAGE>   2

relieve ABI of any obligation to Hayashibara to pay for ACM delivered by
Hayashibara and any payment due hereunder prior to termination.

      If ABI shall at any time during the initial term of any subsequent renewal
term of this Agreement default in any obligation hereunder or fail to pay any
payment due, and such default shall not be cured within sixty (60) days after
written notice from Hayashibara to ABI specifying the nature of the default,
Hayashibara may terminate this Agreement, or may demand specific performance and
remedies for violation of the terms of this Agreement or under applicable law.

      If ABI shall be involved in financial difficulties as evidenced (a) by its
commencement of a voluntary bankruptcy under any applicable bankruptcy code or
statute, or by its authorizing, by appropriate proceedings, the commencement of
such a voluntary bankruptcy; or (b) by its failing to receive dismissal of any
involuntary case under any applicable bankruptcy code or statute within Sixty
(60) days after initiation of such action or petition; or (c) by its seeking
relief as a debtor under any applicable law of any jurisdiction relating to the
liquidation or reorganization of debtors or to the modification or alteration of
the rights of creditors, or by consenting to or acquiescing in such relief; or
(d) by the entry of an order by a court of competent jurisdiction finding it to
be bankrupt or insolvent, or ordering or approving its liquidation,
reorganization or any modification or alteration of the rights of its creditors
or assuming custody of, or appointing a receiver or other custodian for, all or
a substantial part of its property or assets; or (e) by its making an assignment
for the benefit of, or entering into a composition with, its creditors, or
appointing or consenting to the appointment of a receiver or other custodian for
all or a substantial part of its property, this Agreement shall be terminated
immediately.

      Section 4. Orders, Shipment and Payment.

      Actual quantities and delivery dates relating to ACM shall be specified in
purchase orders submitted by ABI to Hayashibara, which purchase orders shall
constitute firm and legally binding orders. Unless otherwise agreed in writing,
Hayashibara hereunder shall accept each individual purchase order by notifying
ABI in writing its acceptance of an order within Ten (10) business days of
receipt of the purchase order. Hayashibara shall ship ACM as specified in such
accepted purchase orders within Thirty (30) days after Hayashibara's acceptance
of a purchase order from ABI. The shipment of ACM under this Agreement shall be
made on f.o.b. Kobe, Japan, unless otherwise agreed in writing. For shipment of
ACM Hayashibara may arrange for a vessel or vessel space in ABI's name at ABI's
cost.

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

<PAGE>   3

      Section 5. Minimum Purchase.

      ABI agrees that, commencing 12 months following the date when the sale of
the Products is commenced, it shall guarantee the annual minimum purchase
quantity of ACM in the amount of 10 MT (metric tons). ABI agrees that the
complete performance of the above minimum purchase guarantee is of essence for
assuring the maintenance and continuation of this Agreement as an exclusive
Supply Agreement. In the event such minimum purchases are not effected, this
Agreement shall become nonexclusive.

      Section 6. Indemnification.

      ABI shall indemnify, hold harmless and defend Hayashibara from all claims,
demands, payments, suits, actions and judgments brought, recovered or executed
against the Parties on account of death, injury or damage sustained by any party
in connection with ABI's distribution, marketing or sales of the Products under
this Agreement, to the extent that such claims are the result of actions or
inactions by ABI or its affiliates acting hereunder pursuant to this Section.

      Hayashibara shall indemnify, hold harmless and defend ABI from all claims,
demands, payments, suits, actions and judgments brought, recovered or executed
against the Parties on account of death, injury or damage sustained by any party
in connection with Hayashibara's manufacture or shipment of ACM under this
Agreement, to the extent that such claims are the result of actions or inactions
by Hayashibara.

      Section 7. Confidentiality.

      Each of the Parties agrees to maintain confidential and secret all
information which may be disclosed or provided to it by the other and that the
Parties may together subsequently acquire in relation to the Products and which
is designated in writing by clearly identifiable legend as being confidential or
secret in character.

      Each Party's obligation to the other (to maintain confidentiality)
hereunder shall terminate with respect to any particular item and only said item
of the disclosing Party's confidential information, when the recipient Party can
demonstrate that such item of information:

      (1)   Is publicly known and available through some means other than by the
recipient Party's act or omission; or

      (2) Was in the recipient Party's possession prior to its disclosure by the
other Party, provided that written evidence of such possession is established;
or

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

<PAGE>   4

      (3) Has come into the recipient Party's possession through a third party
free of any obligation of confidentiality to the disclosing Party, where said
third party has acquired information lawfully and not under circumstances
forbidding its disclosure.

      Neither Party will permit confidential or secret information or any part
thereof to be disclosed to third parties or to employees except on a
"need-to-know" basis and each will maintain confidential or secret information
and/or documents with the same precautions it uses to safeguard its own
confidential or secret information.

      Each Party will notify the other promptly if it has knowledge that a third
party possesses confidential or secret information of the other Party related to
the Products.

      Section 8. Miscellaneous.

      (1) Force Majeure.

            The failure of Hayashibara, ABI, or any of their affiliates or
sublicenses to take any act required by this Agreement if occasioned by an act
of God or the public enemy, fire, explosion, perils of the sea, floods, drought,
war, riot, sabotage, accident, embargo or any circumstances of like or different
character beyond the reasonable control of the Party so failing or by the
interruption or delay in transportation, inadequacy, or shortage or failure of
the supply of materials and/or request of any governmental officer, department
or agency and whether in any case such circumstance now exists or hereafter
arises, shall not subject said Party to any liability to the other.

      (2) Arbitration.

      The Parties hereto desire to avoid and settle without litigation future
disputes that may arise between them relative to this Agreement. Accordingly,
the parties agree to engage in good faith negotiations to resolve any such
dispute. In the event they are unable to resolve any such dispute by
negotiation, such dispute shall be submitted to arbitration as follows: If
arbitration is initiated by Hayashibara, it shall be held in the State of Texas,
USA, in compliance with the Commercial Arbitration Rules of the American
Arbitration Association. If arbitration is initiated by ABI, it shall be held in
Tokyo, Japan in compliance with the Rules of the Japan Commercial Arbitration
Association. The arbitration award shall be final and binding upon the parties
hereto and may be filed with and enforced by any competent court having
competent jurisdiction to enforce said award.

      (3) Communication.

      Any payment, notice or other communication required or permitted to be
made or given to either Party hereto pursuant to this Agreement shall be
sufficiently made or given on the date of sending if sent to such Party by
certified or registered mail or by Federal Express or a similar overnight
courier service, postage or delivery charge prepaid, by telex, or telephone

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

<PAGE>   5

facsimile addressed to it at its address set forth, or to such other address(es)
as it may designate by written notice given to the other Party as follows:

      In case of HBL

            Overseas Business Development
            Hayashibara Company Ltd.
            2-3 Shimoishii 1-chome
            Okayama Japan

      In case of ABI

            Dr. Joseph M. Cummins, President
            Amarillo Biosciences Inc
            800 W 9th Amarillo, Texas 79101

      (4) Assignment.

      This Agreement shall not be assignable by ABI to any person or entity
without prior written consent of HBL, which consent shall not be unreasonably
withheld, in any case including merger, amalgamation, reorganization, or sale or
transfer of major business or assets on ABI. The designation by ABI of one or
more affiliates shall not relieve ABI from any responsibility from performing
all of ABI's obligations under this Agreement. The foregoing notwithstanding,
HBL's prior written consent ABI may transfer or spinoff its nutraceutical
business, including its rights under this Supply Agreement, at anytime to its
shareholders, or to an entity all of whose equity interests are held by ABI
shareholders.

      (5) Amendment.

      This Agreement shall not be amended, in whole or in part, without the
prior written consent of the Parties.

      (6) Nature of Relationship.

      Nothing herein shall be construed to place the Parties in a relationship
of partners or joint ventures, nor does this Agreement make either Party the
agent or legal representative of the other for any purposes whatsoever. The
Parties further agree that no representation shall be made by either Party that
would create an apparent agency, employment, partnership or joint venture.
Neither Party shall have the power express or implied, to obligate the other in
any manner whatsoever.

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

<PAGE>   6

      IN WITNESS WHEREOF, the Parties hereunto have caused this Distribution
Agreement to be executed in duplicate by their duly authorized representatives
as of the date first above written.

ABI                                On behalf of Hayashibara

AMARILLO BIOSCIENCES, INC.         HAYASHIBARA BIOCHEMICAL
                                   LABORATORIES, INC.

By                                 By
  ---------------------------        ---------------------------
Joseph M. Cummins, DVM, PhD        Mr. Ken Hayashibara
President                          President

****    Indicates that a portion of the text has been omitted and filed
        separately with the Commission.

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