Document:

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                                                                   Exhibit 10.62

                            SECOND AMENDMENT TO THE
                       AMGEN SUPPLEMENTAL RETIREMENT PLAN
               AS AMENDED AND RESTATED EFFECTIVE NOVEMBER 1, 1999

          The Amgen Supplemental Retirement Plan as amended and restated
effective November 1, 1999 (the "Plan") is hereby amended, effective January 1,
2002, as follows:

1.   Article I shall be amended and restated in its entirety as follows:

     The Amgen Supplemental Retirement Plan (the "Plan") was established by
     Amgne Inc. (the "Company") effective as of January 1, 1993, was amended and
     restated effective January 1, 1998, and was amended and restated again
     effective November 1, 1999. The purpose of this Plan is to provide benefits
     to employees of the Company and certain of its affiliates and subsidiaries
     whose Matching Contributions and Nonelective Contributions are limited
     under the Amgen Inc. Retirement and Savings Plan (the "Retirement Plan"),
     whether because of statutory limitations or because of employee deferrals
     to the Amgen Nonqualified Deferred Compensation Plan (the "NQDC"). The
     Company intends that the Plan will aid in retaining and attracting
     employees of exceptional ability by providing them with these benefits.

2.   Section 2.7 shall be amended and restated in its entirety as follows:

     2.7 Compensation has the same meaning as such term has under the Retirement
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     Plan, except that, for purposes of this Plan, Compensation is not limited
     by the Salary Cap, includes amounts that are deferred into the NQDC, but
     does not include any foreign assignment differential, that is, an amount
     paid to you to compensate for costs unique to an overseas assignment.

3.   A new Section 2.14 shall be added and all Sections under Article 2 are
     hereby renumbered accordingly, and any references to any Sections under
     Article 2 in the Plan are hereby amended to refer to the Sections as
     renumbered hereunder:

     2.14 NQDC means the Amgen Nonqualified Deferred Compensation Plan.
          ----

4.   Section 3.1 shall be amended and restated in its entirety as follows:

     3.1 Eligibility.  You are eligible to elect to receive credits in your
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     Account as provided in Section 4.2 of the Plan during the time you are a
     Regular Full-Time Employee and either your Compensation for the relevant
     calendar year is in excess of the Salary Cap, or you elect to make a
     deferral into the NQDC.

5.   Section 4.2 shall be amended and restated in its entirety as follows:

     4.2 Credits.  The Company will credit your Account with your share of
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     Matching Credits and Core Credits.

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          (a)  Core Credits. The amount of Core Credits to be credited to your
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               account will be determined by calculating first what you would
               have received as a nonelective contribution under the Retirement
               Plan as if the Salary Cap were not in effect, and as if you had
               not deferred any amounts under the NQDC, less the amount of
               nonelective contributions that were actually contributed on your
               behalf to the Retirement Plan.

          (b)  Matching Credits. The amount of Matching Credits to be credited
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               to your account will be the amount of matching contributions that
               would have been made on your behalf under the Retirement Plan had
               the Salary Cap not been in effect, and had you not deferred any
               amounts under the NQDC, based on your Deferral Commitment in
               effect at the time your Compensation reaches the Salary Cap for
               the year (provided that you can demonstrate to the Company that
               you have set aside for investment an amount equal to the amount
               you were prevented from deferring because of the Salary Cap),
               less the amount of matching contributions that were actually
               contributed on your behalf to the Retirement Plan.

To record this Second Amendment to the Plan as set forth herein, the Company has
caused its authorized officer to execute this document this 1st day of February,
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2002.

                                   AMGEN INC.

                                   By:    /s/ Brian M. McNamee
                                       -----------------------------------------

                                   Title: Senior Vice President, Human Resources
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                                       2<PAGE>

                                                                   Exhibit 10.63

                            THIRD AMENDMENT TO THE
                       AMGEN RETIREMENT AND SAVINGS PLAN
              AS AMENDED AND RESTATED EFFECTIVE OCTOBER 23, 2000

     The Amgen Retirement and Savings Plan as Amended and Restated Effective
October 23, 2000, (the "Plan") is hereby amended as follows:

1.   Section 2.20 shall be amended and restated in its entirety to read as
     follows:

     "Employee"  means an individual who (a) on the Payroll of a member of the
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     Affiliated Group or (b) is a "leased employee" with respect to a member of
     the Affiliated Group.  "Employee" shall not include a nonresident alien who
     receives no earned income (within the meaning of Section 911(b) of the
     Code) from a member of the Affiliated Group that constitutes income from
     sources within the United States (within the meaning of Section 861(a)(3)
     of the Code).

     The term "leased employee" means any person (other than an employee of the
     recipient) who pursuant to an agreement between the recipient and any other
     person ("leasing organization") has performed services for the recipient
     (or for the recipient and related persons determined in accordance with
     section 414(n)(6) of the Internal Revenue Code) on a substantially full
     time basis for a period of at least one year, and such services are
     performed under primary direction or control by the recipient.
     Contributions or benefits provided a leased employee by the leasing
     organization which are attributable to services performed for the recipient
     employer shall be treated as provided by the recipient employer.  A leased
     employee shall not be considered an employee of the recipient if: (i) such
     employee is covered by a money purchase pension plan providing: (1) a
     nonintegrated employer contribution rate of at least 10 percent of
     compensation, as defined in section 415(c)(3) of the Code, but including
     amounts contributed pursuant to a salary reduction agreement which are
     excludable from the employee's gross income under section 125, section
     402(e)(3), section 402(h)(1)(B) or section 403(b) of the Code, (2)
     immediate participation, and (3) full and immediate vesting; and (ii)
     leased employees do not constitute more than 20 percent of the recipient's
     nonhighly compensated work force.

2.   Section 5.2 shall be amended and restated in its entirety to read as
     follows:

     Nonelective Contributions.  Subject to the limitations Section 5.6 and
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     Articles 13-16, each Participating Company may, in its discretion, make
     Nonelective Contributions in an amount determined by the Participating
     Company.  Such Nonelective Contributions shall be allocated to each
     Participant in the ratio that such Participant's compensation bears to the
     compensation of all Participants.  The Company, in its sole discretion, may
     determine that the allocation of part or all of the Nonelective
     Contribution for a Plan Year shall be limited to the Nonelective
     Contribution Accounts of Participants who remain Eligible Employees on the
     last day of the relevant Plan Year.  The Company may limit the

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     amount of Compensation that is taken into account for purposes of
     allocating Nonelective Contributions, and it may determine that allocations
     of Nonelective Contributions shall be limited to a specified group of
     Eligible Employees; provided, however, that the Nonelective Contribution
     formula(s) shall not discriminate in favor of Highly Compensated Employees.
     For purposes of allocating such Nonelective Contributions for any Plan Year
     or other allocation period based on an Employee's Compensation, only
     Compensation attributable to periods in such Plan Year or other allocation
     period during which such Employee was an Eligible Employee shall be taken
     into account. Nonelective Contributions shall be paid to the Trustee as
     soon as reasonably practicable following the close of the pay period to
     which it relates and shall be allocated to the Accounts of Participants as
     provided in Section 6.6.

     Nonelective Contributions may include a core contribution equal to a
     specified percentage of Compensation to be made by the Company for each
     payroll period during the Plan Year.

3.   Section 13.3 shall be amended and restated in its entirety to read as
     follows:

     Allocation of Excess Contributions to Highly Compensated Employees. Any
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     Excess Contributions for a Plan Year shall be allocated to Highly
     Compensated Employees by use of a leveling process, whereby the amount of
     Aggregate 401(k) Contributions of the Highly Compensated Employee with the
     highest amount of Aggregate 401(k) Contributions is reduced to the extent
     required to (a) eliminate all Excess Contributions or (b) cause such Highly
     Compensated Employee's amount of Aggregate 401(k) Contributions to equal
     the amount of Aggregate 401(k) Contributions of the Highly Compensated
     Employee with the next highest amount of Aggregate 401(k) Contributions.
     The leveling process shall be repeated until all Excess Contributions for
     the Plan Year are allocated to Highly Compensated Employees.
     Notwithstanding the foregoing, for Plan Years beginning after December 31,
     1996, any determination of Excess Contributions of a Highly Compensated
     Employee shall be made on the basis of the Highly Compensated Employee's
     actual deferral ratio in accordance with Code Section 401(k)(8)(C) and the
     Regulations promulgated thereunder.

4.   Section 13.4 shall be amended and restated in its entirety to read as
     follows:

     Distribution of Excess Contributions.  Excess Contributions allocated to
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     Highly Compensated Employees for the Plan Year pursuant to Section 13.3,
     together with any income or loss allocable to such Excess Contributions,
     shall be distributed to such Highly Compensated Employees not later than
     two-and-one-half months following the close of such Plan Year, if possible,
     and in any event no later than 12 months following the close of such Plan
     Year.  Any Participant Elected Contributions distributed pursuant to this
     Section 13.4 shall not be included in the Participant Elected Contributions
     to which a Matching Contribution under Section 5.1 or a Qualified Matching
     Contribution under Section 5.4 of the Plan attaches.  Notwithstanding the
     foregoing, for Plan Years beginning after December 31, 1996, any
     distribution of Excess Contributions for a Plan Year to Highly Compensated
     Eligible Employees shall be made on the basis of the dollar

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     amount of Participant Elected Contributions made by, or on behalf of, each
     such Highly Compensated Eligible Employee in accordance with Code Section
     401(k)(8)(C).

5.   Section 13.7(f) shall be amended and restated in its entirety to read as
     follows:

     Income (and loss) allocable to Excess Contributions for the Plan Year shall
     be determined pursuant to the provisions for allocating income (and loss)
     to a Participant's Accounts under Section 6.10 of the Plan.
     Notwithstanding the foregoing, such income and loss shall be calculated
     including the period between the end of the Plan Year and the date on which
     the Excess Contributions are distributed.  The income and loss allocable to
     the Excess Contributions shall bear the same proportion to the total income
     and loss allocable to a Participant's Account as the Excess Contributions
     bear to the Participant's Account.

6.   Section 13.9(e)(5) shall be amended and restated in its entirety to read as
     follows:

     Any of the definitions of Section 414(s) Compensation set forth in
     Subsections (1), (2), (3) and (4) above, modified to include the following:
     (a) any elective contributions made by a member of the Affiliated Group on
     behalf of the Employee that are not includable in gross income under
     Section 125, 132(f)(4), 402(e)(3), 402(h) or 403(b) of the Code; (b)
     compensation deferred under an eligible deferred compensation plan within
     the meaning of Section 457(b) of the Code; and (c) employee contributions
     described in Section 414(h)(2) of the Code that are picked up by the
     employing unit and thus are treated as employer contributions; or

7.   Section 14.2 shall be amended and restated in its entirety to read as
     follows:

     Allocation of Excess Aggregate Contributions to Highly Compensated
     ------------------------------------------------------------------
     Employees.  Any Excess Aggregate Contributions for a Plan Year shall be
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     allocated to Highly Compensated Employees by use of a leveling process,
     whereby the Aggregate 401(m) Contributions of the Highly Compensated
     Employee with the highest amount of Aggregate 401(m) Contributions is
     reduced to the extent required to (a) eliminate all Excess Aggregate
     Contributions or (b) cause the amount of such Highly Compensated Employee's
     Aggregate 401(m) Contributions to equal the amount of Aggregate 401(m)
     Contributions of the Highly Compensated Employee with the next-highest
     amount of Aggregate 401(m) Contributions.  The leveling process shall be
     repeated until all Excess Aggregate Contributions for the Plan Year are
     allocated to Highly Compensated Employees.  Notwithstanding the foregoing,
     for Plan Years beginning after December 31, 1996, any determination of
     Excess Aggregate Contributions of a Highly Compensated Employee shall be
     made on the basis of the Highly Compensated Employee's actual deferral
     ratio in accordance with Code Section 401(k)(8)(C) and the Regulations
     promulgated thereunder.

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8.   Section 14.3 shall be amended and restated in its entirety to read as
     follows:

     Distribution of Excess Aggregate Contributions.  Excess Aggregate
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     Contributions allocated to Highly Compensated Employees for the Plan Year
     pursuant to Section 14.2, together with any income or loss allocable to
     such Excess Aggregate Contributions (calculated to include income and loss
     for the period between the end of the Plan Year and the date on which the
     Excess Aggregate Contributions are distributed), shall be distributed to
     such Highly Compensated Employees not later than two-and-one-half months
     following the close of such Plan Year, if possible, and in any event no
     later than 12 months following the close of such Plan Year, but only to the
     extent the Highly Compensated Employee has a nonforfeitable interest in the
     Excess Aggregate contributions.  Excess Aggregate Contributions (for
     Participants who are Highly Compensated Employees), to the extent not
     vested, may be forfeited and allocated, after all other Forfeitures under
     the Plan, to other Participants (but in no event to any Highly Compensated
     Employee) in the proportion that such Participant's Participant Elected
     Contributions, if any, for that Plan Year bears to the total Participant
     Elected Contributions of all such Participants for the Plan Year.  Any such
     amounts shall be included in the calculation of the Actual Contribution
     Percentage and in the calculation of the limits set forth in Article 16.
     The income and loss allocable to the Excess Aggregate Contributions shall
     bear the same proportion to the total income and loss allocable to a
     Participant's Accounts as the Excess Aggregate Contributions bear to the
     Participant's Accounts.  Notwithstanding the foregoing, for Plan Years
     beginning after December 31, 1996, any distribution of Excess Aggregate
     Contributions for a Plan Year to Highly Compensated Eligible Employees
     shall be made on the basis of the dollar amount of Participant Elected
     Contributions made by, or on behalf of, each such Highly Compensated
     Eligible Employee in accordance with Code Section 401(k)(8)(C).

9.   Section 16.2 shall be deleted in its entirety.

10.  Section 16.4 shall be amended and restated in its entirety to read as
     follow:

     Excess Company Contributions.  If the amount of the Company Contributions
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     allocated to a Participant for any Plan Year must be reduced to meet the
     limitation described in Section 16.1, then the amount of the reduction
     shall be applied to reduce the total amount that the Participating
     Companies otherwise would contribute for such year pursuant to Article 5 of
     the Plan.  If the amount that the Participating Companies may contribute is
     thereby reduced to zero and if there are Company Contributions that still
     cannot be allocated to any Participant because of the limitation described
     in Section 16.1, then the excess shall be transferred to a suspense
     account.  Any gains, income or losses attributable to the suspense account
     shall be allocated to such account.  All amounts credited to the suspense
     account shall be applied to reduce the total amount that the Participating
     Companies otherwise would contribute to the Plan for the next Plan Year,
     and for succeeding Plan Years if necessary.  Such amounts shall be
     allocated among Participants pursuant to Article 5 of the Plan until the
     suspense account is exhausted

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     (subject to this Article). No Participant Elected Contributions or Company
     Contributions shall be made as long as any amount remains in the suspense
     account. However, this method of addressing Excess Company Contributions
     will only be permitted in the event the excess Annual Additions result from
     the allocation of forfeitures or result from a reasonable error in
     determining the amount of elective deferrals under section 401(g)(3).

To record this Third Amendment to the Plan as set forth herein, the Company has
caused its authorized officer to execute this document this 1st day of February,
                                                            ---        --------
2002.

                                   AMGEN INC.

                                   By:    /s/ Brian M. McNamee
                                      --------------------------------

                                   Title: Senior Vice President, Human Resources
                                         ---------------------------------------

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