Document:

Account Pledge Agreement

  
 Exhibit 10.2 
  
 ACCOUNT PLEDGE AGREEMENT 
  
 ACCOUNT PLEDGE
AGREEMENT  (“this Agreement”) dated as of September 25, 2002 between Essential Therapeutics, Inc., a Delaware corporation (the “Pledgor”) and Fleet National Bank (the “Pledgee”). 
  
 1.    BACKGROUND.  The Pledgee has established a term loan facility for the Pledgor pursuant to which the
Pledgee may make loans (“Term Loans”) to the Pledgor in an aggregate principal amount up to $2,000,000. The Term Loans are to be made pursuant to a letter agreement of even date herewith (the “Letter Agreement”). The Pledgor has
agreed in the Letter Agreement to cash-collateralize the Term Loans. This Agreement is delivered pursuant to the Letter Agreement. 
  
 2.    SECURITY.  As security for the below-defined Secured Obligations, the Pledgor hereby transfers, pledges and assigns to the Pledgee, and hereby grants a security interest to the Pledgee in,
all of the Collateral (as hereinafter defined) and all proceeds thereof. As used herein, the term “Secured Obligations” means each of the following: (i) the full and punctual payment when due, whether at stated maturity, by acceleration or
otherwise, of all liabilities of the Pledgor to the Pledgee, whether for reimbursement payments, interest, fees, expenses or otherwise, now existing or hereafter arising under the Letter Agreement and/or with respect to the Term Note (as defined in
the Letter Agreement), (ii) the performance and observance by the Pledgor of all of the Pledgor’s agreements, warranties and covenants contained in the Letter Agreement, (iii) the performance and observance by the Pledgor of all agreements,
warranties and covenants in this Agreement, and (iv) the payment and performance as and when due of all indebtedness, obligations, agreements and liabilities, direct or indirect, matured or unmatured, primary or secondary, certain or contingent,
whether or not otherwise secured or guaranteed, of the Pledgor to the Pledgee, whether now owed or existing or hereafter owing or incurred, and all whether arising out of or under the Letter Agreement or otherwise, including, without limitation,
costs and expenses incurred by the Pledgee in collecting or enforcing or attempting to collect or enforce any of the foregoing. 
  
 As used herein, “Collateral” means (i) the below-defined Investment Account and all securities, investments and other property from time to time held in the Investment Account and all rights and entitlements of the Pledgor
in or with respect to the Investment Account and/or in or with respect to such securities, investments and other property from time to time held in the Investment Account and (ii) all replacements of, substitutions for and distributions in respect
of any of the foregoing, and all proceeds thereof, unless specifically released pursuant to Section 3 below. The securities initially held in the Investment Account are identified on Schedule A hereto. 
  
 3.    TRADING IN INVESTMENT ACCOUNT; WITHDRAWALS.  The Pledgor agrees to maintain pledged to the Pledgee,
subject to this Agreement, Permitted Investments (defined below) having an Aggregate Collateral Value (defined below) which shall at all times be greater than or equal to the aggregate outstanding principal amount of the Term Loans. The
“Aggregate Collateral Value” as at any date means the sum of the then current Collateral Values of each item of Permitted Investments which constitutes Collateral owned by the Pledgor and as to which the Pledgee has a fully perfected first
priority security interest. The “Collateral Value” 

  
 of each item of Permitted Investments so pledged as Collateral is the product of (x) the fair market
value (as reasonably determined by the Pledgee) of such item times (y) the Advance Rate Percentage applicable to such item. As used herein, “Permitted Investments” means each of the types of investments set forth in the following
clauses (1)-(3) and the Advance Rate Percentage applicable to each such type of investment is as follows: (1) cash and certificates of deposit issued by the Pledgee — Advance Rate Percentage of 100%; (2) United States Treasury bills, notes and
bonds — Advance Rate Percentage of 100%; and (3) bonds and other obligations which as to principal and interest constitute direct obligations of, or are guaranteed by, any agency of the United States of America — Advance Rate Percentage of
80%. “Permitted Investments” will also be deemed to include any mutual fund which is primarily invested in one or more of the items described in clauses (1)-(3) above and which is offered by a sponsor with which the Pledgee maintains an
“omnibus account” arrangement and which is otherwise reasonably satisfactory to the Pledgee. Such a mutual fund will be deemed to carry the Advance Rate Percentage applicable to the type of investment in which it is primarily invested
(and, if invested in more than one such type, a weighted average of the relevant Advance Rate Percentages, calculated based on the relative amounts so invested in each such type, as determined by the Pledgee in its sole discretion). 

 
 At any time and from time to time the Pledgor may purchase, sell, redeem, exchange or otherwise deal in the securities, cash
and other items from time to time held in the Investment Account; provided that (i) unless the Pledgee has given its prior written consent (which consent the Pledgee agrees to give under the circumstances set forth in the last sentence of this
paragraph), the proceeds of any sale, redemption, exchange or other dealing in securities described above in this sentence will be credited to the Investment Account and will be held therein, (ii) no such securities, cash or other items shall be
purchased, sold, redeemed, exchanged or otherwise dealt in by the Pledgor at any time when an Event of Default (defined below) has occurred and is continuing, and (iii) the Pledgor will not purchase for the Investment Account or otherwise permit the
Investment Account to hold any property other than Permitted Investments. The Pledgee will, from time to time at the request of the Pledgor, consent to the withdrawal from the Investment Account and the release from the Collateral pledged hereunder
of securities designated for this purpose by the Pledgor; provided that the Pledgee will not be required to give such consent unless both of the following conditions are met: (1) at the date of each such withdrawal and/or release, and after
giving effect thereto, there will be no Default or Event of Default (each as defined below), and (2) in any event, after giving effect in any such withdrawal and/or release there shall remain Permitted Investments pledged as Collateral hereunder in
which the Pledgee has a fully perfected first priority security interest with an Aggregate Collateral Value of not less than the aggregate outstanding principal amount of the Term Loans. 
  
 Promptly following the end of each month in which there is any change in the securities contained in the Investment Account, the Pledgor shall deliver to the Pledgee a
listing of all such securities, which listing shall be substituted for the Schedule A to this Agreement theretofore in effect and shall serve as an amendment to this Agreement. The Pledgor represents, warrants and agrees that no portion of the
proceeds of any Term Loan will be used for the purposes of acquiring or carrying any “margin stock” within the meaning of Regulation U promulgated by the Board of Governors of the Federal Reserve System. 

 
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 4.    COLLATERAL.  All Collateral shall be held by
the Pledgee in a separate account (the “Investment Account”) standing in the name of the Pledgor. The Pledgor agrees to give all such notices and make all such filings with respect to any and all Collateral and to take all other actions
requested by the Pledgee as may be required in order to maintain the transfer, perfection and priority of the security interests of the Pledgee in all of the Collateral. Without limiting the generality of the foregoing, the Pledgor agrees that all
of the securities constituting the Collateral shall be held in the Investment Account. The Pledgee shall be the only person or entity on whose books the Pledgor will permit the interest of the Pledgor in any Collateral to appear. The Pledgor
authorizes the filing of appropriate Uniform Commercial Code financing statements with respect to the Collateral. This Agreement is intended to serve as a “control agreement” within the meaning of the Uniform Commercial Code with respect
to the Collateral and the Pledgor will take all steps required to ensure the Pledgee’s control of the Collateral. As a security device, the Pledgee may require the Collateral to be transferred into the name of the Pledgee. 

 
 5.    REPRESENTATIONS AND WARRANTIES.  The Pledgor represents, warrants and agrees that: (a) the
Pledgor has and will maintain good and valid title to the Collateral, free and clear of any liens, charges or encumbrances thereon or affecting the title thereto (except for the security interest created hereby); and no Collateral consisting of
uncertificated securities is subject to any registered pledge; (b) the Pledgor has good right and lawful authority to pledge, mortgage, assign, transfer, deliver, deposit, set over and confirm unto the Pledgee the Collateral as provided herein and
the Pledgor will warrant and defend the title thereto and the security interest therein conveyed to the Pledgee by this Agreement against all claims of all persons and will maintain and preserve such security interest; (c) none of the Collateral is
restricted as to its use or disposition by any contract, donative or testamentary instrument or otherwise in any manner which could prevent the pledge of same to the Pledgee or the Pledgee’s foreclosure of such pledge; and (d) the execution,
delivery and performance of this Agreement and the pledge and/or delivery of the Collateral to the Pledgee do not and will not contravene the charter documents or by-laws of the Pledgor or any agreement, commitment, indenture, contract or other
obligation or restriction affecting the Pledgor. The Pledgor covenants that the Pledgor will have the like title to and right to pledge any other property of the Pledgor at any time hereafter purported to be pledged to the Pledgee hereunder.

  
 6.    EVENTS OF DEFAULT.  As used herein, an “Event of Default” shall be
deemed to have occurred upon the existence or occurrence of any one or more of the following: (a) the failure by the Pledgor to pay to the Pledgee any sum when due under the Letter Agreement and/or the Term Note; (b) any representation or warranty
of the Pledgor made herein or in connection herewith shall at any time prove to have been false in any material respect when made; (c) the Pledgor shall default in the performance of any agreement under Section 12 within the time period for such
performance set forth in such Section; (d) the Pledgor shall default in the performance of any other term, covenant or agreement contained in this Agreement and such default shall continue unremedied for fifteen (15) days after notice thereof shall
have been given to the Pledgor; (e) this Agreement shall in any respect not be the legal, valid and binding obligation of the Pledgor, enforceable in accordance with its terms; (f) any other “Event of Default” defined in the Letter
Agreement shall exist and shall remain unwaived or uncured beyond the expiration of any applicable notice and/or grace period; or (g) if for any reason (other than payment in full of all Secured Obligations or a written release given by the Pledgee)
the 

 
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 Pledgee does not have a fully perfected first priority security interest in the Investment Account and all of the Collateral. As used herein,
“Default” means any event or circumstance which, with the giving of notice or the passage of time or both, could become an Event of Default. 
  
 7.    DIVIDENDS; VOTING RIGHTS.  All interest earned on any Collateral and all cash dividends paid in respect of any Collateral shall be retained in the Investment Account
and held as part of the Collateral, subject, however, to the provisions of Sections 3 and 8. 
  
 Unless and until an
Event of Default shall have occurred and is continuing, the Pledgor shall retain and may exercise all voting rights with respect to Collateral, and all rights with respect to conversion, exchange, subscription, option, warrant and other similar
rights and privileges pertaining to Collateral (“Rights”); provided that if an Event of Default occurs and is continuing, all Rights shall be exercisable only by or with the prior written consent of the Pledgee; and provided further that
the Pledgee shall not have any voting Rights unless and until it shall have given the Pledgor written notice that such Event of Default has occurred and is continuing and that the Pledgee may exercise, or intends to exercise, any such voting Right,
and the Pledgee shall have no duty at any time whatsoever to exercise any Right and shall not be responsible for any failure to do so or delay in so doing. 
  
 8.    REMEDIES IN CASE OF AN EVENT OF DEFAULT.  If an Event of Default has occurred and is continuing, the Pledgee shall have the right to exercise in respect of the
Collateral all the rights and remedies available to a secured party under the Uniform Commercial Code in effect at the time in The Commonwealth of Massachusetts. To the maximum extent permitted by applicable law, the Pledgee may (after only such
notice to the Pledgor as may be required by applicable law) sell, assign and deliver the whole or, from time to time, any part of the Collateral, or any interest in any part thereof, at any private sale or at public auction, for cash, on credit or
for other property, for immediate or future delivery, and for such price or prices and on such terms as the Pledgee in its uncontrolled discretion may determine; at any such sale the Pledgee may bid for and purchase the whole or any portion of the
Collateral and may make payment therefor by any means. The Pledgee shall apply the cash proceeds actually received by it from any sale or other disposition, together with any other moneys at the time held by it hereunder, to the reasonable expenses
of retaking, holding, preparing for sale, selling and the like, to reasonable attorneys’ fees, brokers’ fees and all other reasonable expenses which may be incurred by the Pledgee in collecting sums due under the Letter Agreement and/or
the Term Note and/or in enforcing this Agreement; and then to principal of and interest on the Secured Obligations; and any amount remaining in excess of the sum of (i) such expenses and (ii) the Secured Obligations shall be paid to the Pledgor. The
Pledgee shall not be required to resort to or marshall any present or future security for, or guaranties of, the obligations secured hereby, or to resort to any such security or guaranties in any particular order. The Pledgee’s remedies shall
be cumulative with all other rights, however existing or arising, and may be exercised concurrently or separately. Neither failure nor delay on the Pledgee’s part to exercise any right, remedy, power or privilege provided for herein or by
statute or at law or in equity shall operate as a waiver thereof, nor shall any single or partial exercise of any such right, remedy, power or privilege preclude any other further exercise thereof or the exercise of any other right, remedy, power or
privilege. 

 
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 The Pledgor recognizes that the Pledgee may be unable to effect a public sale of
the Collateral by reason of certain prohibitions contained in the Securities Act of 1933, as amended, but may be compelled to resort to one or more private sales thereof to a restricted group of purchasers who will be obligated to agree, among other
things, to acquire such securities for their own account, for investment and not with a view to the distribution or resale thereof. The Pledgor agrees that any such private sales may be at prices and on other terms less favorable to the seller than
if sold at public sales and that such private sales shall not be deemed to have been made in a commercially unreasonable manner on account of their private character. 
  
 Beyond the exercise of reasonable care to assure the physical safekeeping of Collateral (if any) while held in the Pledgee’s possession, the Pledgee shall have no duty
or liability to preserve rights pertaining to any Collateral. 
  
 In addition to the above-described rights to
realize upon Collateral, upon the occurrence and during the continuance of an Event of Default, the Pledgee may liquidate the Investment Account and apply the proceeds thereof to the Secured Obligations. 
  
 9.    PLEDGOR’S OBLIGATIONS NOT AFFECTED; RELEASE.  The obligations of the Pledgor under this Agreement
shall remain in full force and effect without regard to, and shall not be impaired or affected by, any amendment or modification of or addition or supplement to the Letter Agreement or the Term Note or any waiver, consent, extension, indulgence or
other action or inaction in respect of this Agreement, the Letter Agreement and/or the Term Note. This Agreement and the pledge and security interest granted hereby shall be of no further force or effect when there are no long any Term Loans
outstanding and all Secured Obligations have been paid in full and satisfied, and, forthwith thereafter, the Pledgee will release to the Pledgor all Collateral then held hereunder, together with appropriate releases and discharges of such pledge and
security interest. 
  
 10.    NOTICE.  All notices and other communications to any
party hereunder shall be in writing. Each such notice, request or communication shall be deemed delivered on the earlier of (a) the date received or (b) the date of delivery, refusal or nondelivery indicated on the return receipt, if deposited in a
United States Postal Service Depository, postage prepaid, sent certified or registered mail, return receipt requested, addressed as provided in the Letter Agreement. 
  
 11.    FURTHER ASSURANCES.  The Pledgor will do all such acts, and will furnish to the Pledgee all such financing statements, certificates,
opinions and other documents, and will do or cause to be done all such other things, as the Pledgee may reasonably request from time to time in order to give full effect to this Agreement and to secure the rights of the Pledgee hereunder. The
Pledgor hereby authorizes the filing of financing statements describing the Collateral. 
  
 12.    MONTHLY VALUATION; MINIMUM VALUE.  If, at the last day of any month, the Collateral Value of Permitted Investments consisting of cash, certificates of deposit and United States Treasury bills,
notes and bonds is less than the aggregate principal amount of the Term Loans, then the Pledgor will value (or cause to be valued) each item held as Collateral in the Investment Account as at the last day of each month, commencing on the first such
date after the date of this Agreement. Within five business days after the end of each such month, the Pledgor will supply to the Pledgee a listing of all such items and the fair market value of each 

 
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 such item. Without limitation of the foregoing, if at any date the Pledgor has actual knowledge (or is notified by the Pledgee) that the
Collateral has an Aggregate Collateral Value which is less than the then aggregate outstanding principal amount of the Term Loans for any reason (including, without limitation, due to any decline in value of any Collateral), then the Pledgor shall
immediately notify the Pledgee (unless the Pledgor had been so notified by the Pledgee) by telephone or facsimile transmission of such shortfall in Aggregate Collateral Value and, in any event, the Pledgor shall deposit into the Investment Account,
within two business days after the Pledgor has such actual knowledge or forthwith upon being so notified of any such shortfall, additional cash or securities, to be held as Collateral hereunder, in such amount so that the Aggregate Collateral Value
of the Collateral then so held will not be less than the then aggregate outstanding principal amount of the Term Loans or shall (within said two business day period) prepay Term Loans in such amount as may be necessary to ensure that such Aggregate
Collateral Value is not less than the then outstanding principal amount of the Term Loans. 
  
 13.    COSTS AND EXPENSES.  The Pledgor agrees to pay to the Pledgee on demand any and all reasonable costs and expenses, and to indemnify and hold harmless the Pledgee from and against any and all
claims, demands, damages and liabilities, that may be asserted against, incurred by or paid by the Pledgee in connection with the Collateral, this Agreement or the preparation, amendment, modification, interpretation, administration or enforcement
of this Agreement. 
  
 14.    MISCELLANEOUS.  Neither this Agreement nor any provisions
hereof may be amended, modified, waived, discharged or terminated orally, but only by an instrument in writing signed by the party against whom enforcement of the amendment, modification, waiver, discharge or termination is sought. The provisions of
this Agreement shall be binding upon and shall inure to the benefit of the heirs, executors, successors and assigns of the Pledgor and the Pledgee. The captions in this Agreement are added for convenience of reference only and shall not define or
limit any provisions hereof. This Agreement shall be construed and enforced in accordance with the laws of The Commonwealth of Massachusetts. This Agreement may be executed simultaneously in several counterparts, each of which will be deemed an
original, but all of which together shall constitute one instrument. If any term or provision of this Agreement or the application thereof to any person, property or circumstance shall to any extent be invalid or unenforceable, the remainder of this
Agreement and the application of such term or provision to persons, properties and circumstances other than those as to which it is invalid or unenforceable shall not be affected thereby, and each term and provision of this Agreement shall be valid
and enforced to the fullest extent permitted by law. 
  
 15.    CONSENT TO JURISDICTION; JURY
TRIAL WAIVER.  (a) The Pledgor irrevocably submits to the non-exclusive jurisdiction of any Massachusetts court or any federal court sitting within The Commonwealth of Massachusetts over any suit, action or proceeding arising out of or
relating to this Agreement. The Pledgor irrevocably waives, to the fullest extent permitted by law, any objection which it may now or hereafter have to the laying of venue of any such suit, action or proceeding brought in such a court and any claim
that any such suit, action or proceeding has been brought in an inconvenient forum. The Pledgor agrees that final judgment in any such suit, action or proceeding brought in such a court shall be enforced in any court of proper jurisdiction by a suit
upon such judgment, provided that service of process in such action, suit or proceeding shall have been effected upon the Pledgor in a manner permitted by law. 

 
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 (b)    THE PARTIES HERETO HEREBY KNOWINGLY, VOLUNTARILY AND
INTENTIONALLY MUTUALLY WAIVE THE RIGHT TO A TRIAL BY JURY IN RESPECT OF ANY CLAIM BASED HEREON, ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS AGREEMENT, THE LETTER AGREEMENT, THE TERM NOTE OR ANY OTHER RELATED DOCUMENTS OR OUT OF ANY COURSE OF
CONDUCT, COURSE OF DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN) OR ACTIONS OF THE PLEDGEE RELATING TO THE ADMINISTRATION OF THE TERM LOANS OR THE ADMINISTRATION OR ENFORCEMENT OF THIS AGREEMENT, THE LETTER AGREEMENT OR ANY RELATED DOCUMENTS, AND
AGREE THAT NEITHER PARTY WILL SEEK TO CONSOLIDATE ANY SUCH ACTION WITH ANY OTHER ACTION IN WHICH A JURY TRIAL CANNOT BE OR HAS NOT BEEN WAIVED. EXCEPT AS PROHIBITED BY LAW, THE PLEDGOR HEREBY WAIVES ANY RIGHT IT MAY HAVE TO CLAIM OR RECOVER IN ANY
LITIGATION ANY SPECIAL, EXEMPLARY, PUNITIVE OR CONSEQUENTIAL DAMAGES OR ANY DAMAGES OTHER THAN, OR IN ADDITION TO, ACTUAL DAMAGES. THE PLEDGOR CERTIFIES THAT NO REPRESENTATIVE, AGENT OR ATTORNEY OF THE PLEDGEE HAS REPRESENTED, EXPRESSLY OR
OTHERWISE, THAT THE PLEDGEE WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER. THIS WAIVER CONSTITUTES A MATERIAL INDUCEMENT FOR THE PLEDGEE TO ENTER INTO THE LETTER AGREEMENT AND TO MAKE TERM LOANS AS CONTEMPLATED THEREIN.

  
 IN WITNESS WHEREOF, the Pledgor and the Pledgee have caused this Agreement to be duly executed, as an instrument
under seal, as of the day and year first above written. 
  
 
	 ESSENTIAL THERAPEUTICS, INC. 
 
	 
	 By:
 	 	 /s/    MARK
SKALETSKY        
 

	  	 	 Name: Mark Skaletsky
 Title: Chief Executive Officer
 

 
  
  
  
 
	 FLEET NATIONAL BANK
 
	 
	 By:
 	 	 /s/    DAVID E.
MEAGHER        
 

	  	 	 Name: David E. Meagher
 Title: Assistant Vice President
 

 

 
 72000 Nonstatutory Incentive Plan

 EXHIBIT 10.65 
  
  
  
 CV THERAPEUTICS, INC. 
  
 2000 Nonstatutory Incentive Plan 
  
 ADOPTED BY THE
BOARD OF DIRECTORS JULY 19, 2000 
 AMENDED AND
RESTATED BY THE BOARD OF DIRECTORS FEBRUARY 9, 2001 
 AMENDED AND RESTATED BY THE BOARD OF DIRECTORS JULY 20, 2001 
 AMENDED AND RESTATED BY THE BOARD OF DIRECTORS
DECEMBER 9, 2001 
 AMENDED AND RESTATED BY THE
BOARD OF DIRECTORS FEBRUARY 25, 2002 
 AMENDED AND
RESTATED BY THE BOARD OF DIRECTORS JUNE 7, 2002 
 AMENDED AND RESTATED BY THE BOARD OF DIRECTORS AUGUST 29, 2002 
 AMENDED AND RESTATED BY THE BOARD OF DIRECTORS
OCTOBER 18, 2002 
  
 1.    PURPOSES. 
  
 (a)    Eligible Stock Award Recipients.    Only Eligible Participants may receive
Stock Awards under this Plan. 
  
 (b)    Available Stock
Awards.    The purpose of the Plan is to provide a means by which Eligible Participants may be given an opportunity to benefit from increases in value of the Common Stock through the granting of Nonstatutory Stock Options.

  
 (c)    General Purpose.    The Company, by means of the
Plan, seeks to retain the services of the group of persons eligible to receive Stock Awards, to secure and retain the services of new members of this group and to provide incentives for such persons to exert maximum efforts for the success of the
Company and its Affiliates. 
  

	2.    DEFINITIONS.
	 
	
 

  
 (a)    “Affiliate” means any parent corporation or subsidiary corporation of the Company, whether now or hereafter existing, as those terms are defined in Sections 424(e) and (f),
respectively, of the Code. 
  
 (b)    “Board” means the Board of
Directors of the Company. 
  
 (c)    “Code” means the Internal
Revenue Code of 1986, as amended. 
  
 (d)    “Committee” means a
committee of one or more members of the Board appointed by the Board in accordance with subsection 3(c). 
  
 (e)    “Common Stock” means the common stock of the Company. 
  
 (f)    “Company” means CV Therapeutics, Inc., a Delaware corporation. 
  
 (g)    “Consultant” means any person, including an advisor, (i) engaged by the Company or an Affiliate to render consulting or advisory services and who is compensated for
such services or (ii) who is a member of the Board of Directors of an Affiliate. However, the term “Consultant” shall not include Directors. 

 
 1 

  
 (h)    “Continuous Service”
means that the Holder’s service with the Company or an Affiliate, whether as an Employee or Consultant, is not interrupted or terminated. The Holder’s Continuous Service shall not be deemed to have terminated merely because of a change in
the capacity in which the Holder renders service to the Company or an Affiliate as an Employee or Consultant or a change in the entity for which the Holder renders such service, provided that there is no interruption or termination of the
Holder’s service to the Company or an Affiliate. For example, a change in status without interruption from an Employee of the Company to a Consultant of an Affiliate will not constitute an interruption of Continuous Service. The Board or the
chief executive officer of the Company, in that party’s sole discretion, may determine whether Continuous Service shall be considered interrupted in the case of any leave of absence approved by that party, including sick leave, military leave
or any other personal leave. 
  
 (i)    “Director” means a member
of the Board of Directors of the Company. 
  
 (j)    “Disability”
means the permanent and total disability of a person within the meaning of Section 22(e)(3) of the Code. 
  
 (k)    “Eligible Participant” means any Employee or Consultant; provided, however, that except as provided in the following sentence, no Employee or Consultant who is a Director or
an Officer may be granted Stock Awards under this Plan. Notwithstanding the preceding sentence, an Officer may be an Eligible Participant if he or she is granted a Stock Award in connection with his or her initial commencement of employment with the
Company and such grant is an essential inducement to his or her entering into a contract of employment with the Company. 
  
 (l)    “Employee” means any person employed by the Company or an Affiliate. Mere service as a Director or payment of a director’s fee by the Company or an Affiliate shall not be
sufficient to constitute “employment” by the Company or an Affiliate. 
  
 (m)    “Exchange Act” means the Securities Exchange Act of 1934, as amended. 
  
 (n)    “Fair Market Value” means, as of any date, the value of the Common Stock determined as follows: 
  
 (i)    If the Common Stock is listed on any established stock exchange or traded on the Nasdaq National Market
or the Nasdaq SmallCap Market, the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange or market (or the exchange or market with the
greatest volume of trading in the Common Stock) on the last market trading day prior to the day of determination, as reported in The Wall Street Journal or such other source as the Board deems reliable. 
  
 (ii)    In the absence of such markets for the Common Stock, the Fair Market Value shall be determined in good
faith by the Board. 
  
 (o)    “Holder” means a person to whom a
Stock Award is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Stock Award. 

 
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 (p)    “Incentive Stock
Option” means an Option intended to qualify as an incentive stock option within the meaning of Section 422 of the Code and the regulations promulgated thereunder. Incentive Stock Options may not be granted under the Plan. 

 
 (q)    “Nonstatutory Stock Option” means an Option not intended to qualify
as an Incentive Stock Option. 
  
 (r)    “Officer” means a person
who is either (i) an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder or (ii) an officer of the Company within the meaning of Section 4310(c)(25)(G)(i) of the NASD
Manual and Notices to Members (the “NASD Manual”), or any successor provision thereto. 
  
 (s)    “Option” means a Nonstatutory Stock Option granted pursuant to the Plan. 
  
 (t)    “Option Agreement” means a written or electronic agreement between the Company and an Optionholder evidencing certain terms and conditions of
an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of the Plan. 
  
 (u)    “Optionholder” means a person to whom an Option is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option. 
  
 (v)    “Plan” means this CV Therapeutics, Inc. 2000 Nonstatutory Incentive Plan.

  
 (w)    “Rule 16b-3” means Rule 16b-3 promulgated under the
Exchange Act or any successor to Rule 16b-3, as in effect from time to time. 
  
 (x)    “Securities Act” means the Securities Act of 1933, as amended. 
  
 (y)    “Stock Award” means any Option granted under the Plan. 
  
 (z)    “Stock Award Agreement” means a written agreement between the Company and a Holder of a Stock Award evidencing the terms and conditions of an individual Stock Award
grant. Each Stock Award Agreement shall be subject to the terms and conditions of the Plan. 
  
 3.    ADMINISTRATION. 
  
 (a)    Administration by Board.    The Board shall administer the Plan unless and until the Board delegates administration to a Committee, as provided in subsection 3(c).

  
 (b)    Powers of Board.    The Board shall have the power,
subject to, and within the limitations of, the express provisions of the Plan: 
  
 (i)    To determine from time to time which of the persons eligible under the Plan shall be granted Stock Awards; when and how each Stock Award shall be granted; what type or combination of types of Stock
Award shall be granted; the provisions of each Stock Award granted (which need not be identical), including the time or times when a person shall be permitted to receive Common Stock pursuant to a Stock Award; and the number of shares of Common
Stock with respect to which a Stock Award shall be granted to each such person. 

 
 3 

  
 (ii)    To construe and interpret the Plan and Stock
Awards granted under it, and to establish, amend and revoke rules and regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Stock Award Agreement, in a
manner and to the extent it shall deem necessary or expedient to make the Plan fully effective. 
  
 (iii)    To amend the Plan or a Stock Award as provided in Section 11. 
  
 (iv)    To terminate or suspend the Plan as provided in Section 12. 
  
 (v)    Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the best interests of the Company which are not in conflict with the provisions of the
Plan. 
  
 (c)    Delegation to Committee.    The Board may
delegate administration of the Plan to a Committee or Committees of one (1) or more members of the Board. The term “Committee” shall apply to any person or persons to whom such authority has been delegated. If administration is delegated
to a Committee, the Committee shall have, in connection with the administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is
authorized to exercise (and references in this Plan to the Board shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by
the Board. The Board may abolish the Committee at any time and revest in the Board the administration of the Plan. 
  
 (d)    Effect of Board’s Decision.    All determinations, interpretations and constructions made by the Board in good faith shall not be subject to review by any person and
shall be final, binding and conclusive on all persons. 
  
 4.    SHARES SUBJECT
TO THE PLAN. 
  
 (a)    Share
Reserve.    Subject to the provisions of Section 10 relating to adjustments upon changes in Common Stock, the Common Stock that may be issued pursuant to Stock Awards shall not exceed in the aggregate Two Million Six Hundred
and Ten Thousand Three Hundred and Twenty Five (2,610,325) shares of Common Stock. 
  
 (b)    Reversion of Shares to the Share Reserve.    If any Stock Award shall for any reason expire or otherwise terminate, in whole or in part, without having been exercised in
full, the shares of Common Stock not acquired under such Stock Award shall revert to and again become available for issuance under the Plan. 
  
 (c)    Source of Shares.    The shares of Common Stock subject to the Plan may be unissued shares or reacquired shares, bought on the market or
otherwise. 
  
 5.    ELIGIBILITY. 
  
 (a)    Eligibility for Specific Stock Awards.    Stock Awards may be granted only to Eligible Participants. 

 
 4 

  
 (b)    Consultants.    A
Consultant shall not be eligible for the grant of a Stock Award if, at the time of grant, a Form S-8 Registration Statement under the Securities Act (“Form S-8”) is not available to register either the offer or the sale of the
Company’s securities to such Consultant because of the nature of the services that the Consultant is providing to the Company, or because the Consultant is not a natural person, or as otherwise provided by the rules governing the use of Form
S-8, unless the Company determines both (i) that such grant (A) shall be registered in another manner under the Securities Act (e.g., on a Form S-3 Registration Statement) or (B) does not require registration under the Securities Act in order
to comply with the requirements of the Securities Act, if applicable, and (ii) that such grant complies with the securities laws of all other relevant jurisdictions. 
  
 6.    OPTION PROVISIONS. 
  
 (a)    Each Option shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. The provisions of separate Options need not be identical, but each Option shall
include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of each of the following provisions: 
  
 (b)    Option Exercise Price.    The exercise price of each Option shall be not less than one hundred percent (100%) of the Fair Market Value of
the Common Stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, a Option may be granted with an exercise price lower than that set forth in the preceding sentence if such Option is granted pursuant to an
assumption or substitution for another option in a manner satisfying the provisions of Section 424(a) of the Code. 
  
 (c)    Consideration.    The purchase price of Common Stock acquired pursuant to an Option shall be paid, to the extent permitted by applicable statutes and regulations, either
(i) in cash at the time the Option is exercised or (ii) at the discretion of the Board at the time of the grant of the Option (or subsequently in the case of a Nonstatutory Stock Option) (1) by delivery to the Company of other Common Stock, (2)
according to a deferred payment or other similar arrangement with the Optionholder or (3) in any other form of legal consideration that may be acceptable to the Board. Unless otherwise specifically provided in the Option, the purchase price of
Common Stock acquired pursuant to an Option that is paid by delivery to the Company of other Common Stock acquired, directly or indirectly from the Company, shall be paid only by shares of the Common Stock of the Company that have been held for more
than six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting purposes). At any time that the Company is incorporated in Delaware, payment of the Common Stock’s “par
value,” as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 
  
 (d)    In the case of any deferred payment arrangement, interest shall be compounded at least annually and shall be charged at the minimum rate of interest necessary to avoid the treatment as interest,
under any applicable provisions of the Code, of any amounts other than amounts stated to be interest under the deferred payment arrangement. 
  
 (e)    Transferability of a Nonstatutory Stock Option.    A Nonstatutory Stock Option shall be transferable to the extent provided in the Option
Agreement. If the Nonstatutory Stock Option does not provide for transferability, then the Nonstatutory Stock Option shall not be

 
 5 

 
transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing,
the Optionholder may, by delivering written notice to the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 

 
 (f)    Vesting Generally.    The total number of shares of Common Stock
subject to an Option may, but need not, vest and therefore become exercisable in periodic installments that may, but need not, be equal. The Option may be subject to such other terms and conditions on the time or times when it may be exercised
(which may be based on performance or other criteria) as the Board may deem appropriate. The vesting provisions of individual Options may vary. The provisions of this subsection 6(d) are subject to any Option provisions governing the minimum number
of shares of Common Stock as to which an Option may be exercised. 
  
 (g)    Termination of Continuous Service.    In the event an Optionholder’s Continuous Service terminates (other than upon the Optionholder’s death or Disability), the
Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination) but only within such period of time ending on the earlier of (i) the date three (3) months following
the termination of the Optionholder’s Continuous Service (or such longer or shorter period specified in the Option Agreement), or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the
Optionholder does not exercise his or her Option within the time specified in the Option Agreement, the Option shall terminate. 
  
 (h)    Extension of Termination Date.    An Optionholder’s Option Agreement may also provide that if the exercise of the Option following the termination of the
Optionholder’s Continuous Service (other than upon the Optionholder’s death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock would violate the registration requirements under the
Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in subsection 6(a) or (ii) the expiration of a period of three (3) months after the termination of the Optionholder’s
Continuous Service during which the exercise of the Option would not be in violation of such registration requirements. 
  
 (i)    Disability of Optionholder.    In the event that an Optionholder’s Continuous Service terminates as a result of the Optionholder’s Disability, the Optionholder
may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination), but only within such period of time ending on the earlier of (i) the date twelve (12) months following such
termination (or such longer or shorter period specified in the Option Agreement) or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option
within the time specified herein, the Option shall terminate. 
  
 (j)    Death of
Optionholder.    In the event (i) an Optionholder’s Continuous Service terminates as a result of the Optionholder’s death or (ii) the Optionholder dies within the period (if any) specified in the Option Agreement
after the termination of the Optionholder’s Continuous Service for a reason other than death, then the Option may be exercised (to the extent the Optionholder was entitled to exercise such Option as of the date of death) by the
 

 
 6 

 
Optionholder’s estate, by a person who acquired the right to exercise the Option by bequest or inheritance or by a person designated to exercise the Option upon the Optionholder’s death
pursuant to subsection 6(e) or 6(f), but only within the period ending on the earlier of (1) the date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement) or (2) the expiration of the
term of such Option as set forth in the Option Agreement. If, after death, the Option is not exercised within the time specified herein, the Option shall terminate. 
  
 (k)    Early Exercise.    The Option may, but need not, include a provision whereby the Optionholder may elect at any
time before the Optionholder’s Continuous Service terminates to exercise the Option as to any part or all of the shares of Common Stock subject to the Option prior to the full vesting of the Option. Any unvested shares of Common Stock so
purchased may be subject to a repurchase option in favor of the Company or to any other restriction the Board determines to be appropriate. The Company will not exercise its repurchase option until at least six (6) months (or such longer or shorter
period of time required to avoid a charge to earnings for financial accounting purposes) have elapsed following exercise of the Option unless the Board otherwise specifically provides in the Option. 
  
 7.    COVENANTS OF THE COMPANY. 
  
 (a)    Availability of Shares.    During the terms of the Stock Awards, the Company
shall keep available at all times the number of shares of Common Stock required to satisfy such Stock Awards. 
  
 (b)    Securities Law Compliance.    The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required
to grant Stock Awards and to issue and sell shares of Common Stock upon exercise of the Stock Awards; provided, however, that this undertaking shall not require the Company to register under the Securities Act the Plan, any Stock Award or any Common
Stock issued or issuable pursuant to any such Stock Award. If, after reasonable efforts, the Company is unable to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful
issuance and sale of Common Stock under the Plan, the Company shall be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. 
  
 8.    USE OF PROCEEDS FROM
STOCK.    Proceeds from the sale of Common Stock pursuant to Stock Awards shall constitute general funds of the Company. 
  
 9.    MISCELLANEOUS. 
  
 (a)    Acceleration of Exercisability and Vesting.    The Board shall have the power to accelerate the time at which a Stock Award may first be exercised or the time during which
a Stock Award or any part thereof will vest in accordance with the Plan, notwithstanding the provisions in the Stock Award stating the time at which it may first be exercised or the time during which it will vest. 
  
 (b)    Stockholder Rights.    No Holder shall be deemed to be the holder of, or to
have any of the rights of a holder with respect to, any shares of Common Stock subject to such Stock

 
 7 

 
Award unless and until such Holder has satisfied all requirements for exercise of the Stock Award pursuant to its terms. 
  
 (c)    No Employment or Other Service Rights.    Nothing in the Plan or any instrument executed or Stock Award granted
pursuant thereto shall confer upon any Holder any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Stock Award was granted or shall affect the right of the Company or an Affiliate to terminate (i) the
employment of an Employee with or without notice and with or without cause or (ii) the service of a Consultant pursuant to the terms of such Consultant’s agreement with the Company or an Affiliate. 
  
 (d)    Investment Assurances.    The Company may require a Holder, as a condition of
exercising or acquiring Common Stock under any Stock Award, (i) to give written assurances satisfactory to the Company as to the Holder’s knowledge and experience in financial and business matters and/or to employ a purchaser representative
reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the purchaser representative, the merits and risks of exercising the
Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Holder is acquiring Common Stock subject to the Stock Award for the Holder’s own account and not with any present intention of selling or otherwise
distributing the Common Stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be inoperative if (1) the issuance of the shares of Common Stock upon the exercise or acquisition of Common Stock under the
Stock Award has been registered under a then currently effective registration statement under the Securities Act or (2) as to any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in the
circumstances under the then applicable securities laws. The Company may, upon advice of counsel to the Company, place legends on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with
applicable securities laws, including, but not limited to, legends restricting the transfer of the Common Stock. 
  
 (e)    Withholding Obligations.    The Holder agrees that he shall be liable for any Employer’s United Kingdom National Insurance Contribution and to the extent provided by
the terms of a Stock Award Agreement, the Company may require that any liability it has to account for United Kingdom income tax under the Pay As You Earn system and National Insurance Contributions or any other federal, state or local tax
withholding obligation relating to the exercise or acquisition of Common Stock under a Stock Award be satisfied by any of the following means (in addition to the Company’s right to withhold from any compensation paid to the Holder by the
Company) or by a combination of such means: (i) tendering a cash payment; (ii) authorizing the Company to withhold shares of Common Stock from the shares of Common Stock otherwise issuable to the Holder as a result of the exercise or acquisition of
Common Stock under the Stock Award, provided, however, that no shares of Common Stock are withheld with a value exceeding the minimum amount of tax required to be withheld by law; or (iii) delivering to the Company owned and unencumbered shares of
Common Stock. 
  
 10.    ADJUSTMENTS UPON CHANGES IN
STOCK. 
  
 (a)    Capitalization
Adjustments.    If any change is made in the Common Stock subject to the Plan, or subject to any Stock Award, without the receipt of consideration by the 

 
 8 

 
Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend, combination of
shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company), the Plan will be appropriately adjusted in the class(es) and maximum number of securities subject to the Plan
pursuant to subsection 4(a) and the maximum number of securities subject to award to any person pursuant to subsection 5(c), and the outstanding Stock Awards will be appropriately adjusted in the class(es) and number of securities and price per
share of Common Stock subject to such outstanding Stock Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. The conversion of any convertible securities of the Company shall not be treated as
a transaction “without receipt of consideration” by the Company. 
  
 (b)    Dissolution or Liquidation.    In the event of a dissolution or liquidation of the Company, then all outstanding Stock Awards shall terminate immediately prior to such event.

  
 (c)    Change of Control.    (i) Subject to clause (ii) below, in
the event of a Change of Control, to the extent permitted by law, any surviving corporation or acquiring corporation may assume any Stock Awards outstanding under the Plan or substitute similar stock awards (including awards to acquire the same
consideration paid to the stockholders in the Change of Control) for those outstanding under the Plan. In the event any surviving corporation or acquiring corporation does not assume such Stock Awards or substitute similar stock awards for those
outstanding under the Plan, then with respect to Stock Awards held by Holders whose Continuous Service has not terminated, the time during which such Stock Awards may be exercised shall be accelerated in full, and the Stock Awards shall terminate if
not exercised at or prior to such event. With respect to any other Stock Awards outstanding under the Plan, such Stock Awards shall terminate if not exercised prior to such event. 
  
 (ii)    In the event of a Change of Control not approved by the Board, each outstanding Stock Award under the Plan shall become fully vested, and
the Company’s right of repurchase shall lapse with respect to shares received upon exercise of a Stock Award prior to full vesting, notwithstanding the terms of the Stock Award or any early exercise stock purchase agreement, immediately prior
to the consummation of such Change of Control. 
  
 (d)    For purposes of this Plan,
“Change of Control” means: (i) a sale of substantially all of the assets of the Company; (ii) a merger or consolidation in which the Company is not the surviving corporation (other than a merger or consolidation in which shareholders
immediately before the merger or consolidation have, immediately after the merger or consolidation, equal or greater stock voting power); (iii) a reverse merger in which the Company is the surviving corporation but the shares of Common Stock
outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or otherwise (other than a reverse merger in which stockholders immediately before the merger have,
immediately after the merger, greater stock voting power); or (iv) any transaction or series of related transactions in which in excess of 50% of the Company’s voting power is transferred. 
  

11.    AMENDMENT OF THE PLAN AND STOCK AWARDS.

  
 (a)    Amendment of Plan.    The Board at any time, and
from time to time, may amend the Plan. However, except as provided in Section 10 relating to adjustments upon changes in

 
 9 

 
Common Stock, no amendment shall be effective unless approved by the stockholders of the Company to the extent stockholder approval is necessary to satisfy the requirements of Section 422 of the
Code, Rule 16b-3 or any Nasdaq or securities exchange listing requirements. 
  
 (b)    Contemplated Amendments.    It is expressly contemplated that the Board may amend the Plan in any respect the Board deems necessary or advisable to provide eligible
Employees with the maximum benefits provided or to be provided under the provisions of the Code. 
  
 (c)    No Impairment of Rights.    Rights under any Stock Award granted before amendment of the Plan shall not be impaired by any amendment of the Plan unless (i) the Company
requests the consent of the Holder and (ii) the Holder consents in writing. 
  
 (d)    Amendment of Stock Awards.    The Board at any time, and from time to time, may amend the terms of any one or more Stock Awards; provided, however, that the rights under
any Stock Award shall not be impaired by any such amendment unless (i) the Company requests the consent of the Holder and (ii) the Holder consents in writing. Notwithstanding the foregoing, the Board shall not, without the approval of the
stockholders of the Company, authorize the amendment of any outstanding Option to reduce its exercise price. Furthermore, no Option shall be canceled and replaced with grants having a lower exercise price without the further approval of stockholders
of the Company. 
  
 12.    TERMINATION OR SUSPENSION OF
THE PLAN. 
  
 (a)    Plan
Term.    The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall terminate on the day before the tenth (10th) anniversary of the date the Plan is adopted by the Board. No Stock Awards
may be granted under the Plan while the Plan is suspended or after it is terminated. 
  
 (b)    No Impairment of Rights.    Suspension or termination of the Plan shall not impair rights and obligations under any Stock Award granted while the Plan is in effect except
with the written consent of the Holder. 
  
 13.    EFFECTIVE DATE OF
PLAN.    The Plan shall become effective upon its adoption by the Board. 
  
 14.    CHOICE OF LAW/INTERPRETATION.    The law of the State of Delaware shall govern all questions concerning the
construction, validity and interpretation of this Plan, without regard to such state’s conflict of laws rules. Notwithstanding the foregoing, it is expressly intended that approval of the Company’s stockholders not be required as a
condition of the effectiveness of the Plan, and the Plan’s provisions shall be interpreted in a manner consistent with such intent for all purposes (including without limitation, for purposes of determining whether stockholder approval of the
Plan is necessary pursuant to the NASD Manual or any successor provisions thereto). 
  
 15.    PARTICIPANTS IN FOREIGN COUNTRIES.    The Board shall have the authority to adopt such modifications, procedures and
subplans as may be necessary or desirable to comply with provisions of the laws of foreign countries in which the Company or any Affiliate may operate to assure the viability of Options granted under the Plan in such countries and to meet the
objectives of the Plan. 

 
 10

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