Document:

EX-10.1

Exhibit 10.1

AMENDMENT NO. 2 TO

AGREEMENT OF LIMITED PARTNERSHIP

OF

GRUBB & ELLIS HEALTHCARE REIT HOLDINGS, LP

THIS AMENDMENT NO. 2 TO AGREEMENT OF LIMITED PARTNERSHIP OF GRUBB & ELLIS HEALTHCARE REIT
HOLDINGS, LP (this “Amendment”), dated as of August 24, 2009, is entered into by Healthcare
Trust of America, Inc. (formerly known as Grubb & Ellis Healthcare REIT, Inc.), a Maryland
corporation, as general partner (the “General Partner”).

W I T N E S S E T H

WHEREAS, the General Partner and Grubb & Ellis Healthcare REIT Advisor, LLC (the “Initial
Limited Partner”) formed Grubb & Ellis Healthcare REIT Holdings, LP (the “Partnership”)
as a limited partnership pursuant to the Act by filing a certificate of limited partnership with
the Secretary of State of the State of Delaware on April 20, 2006;

WHEREAS, the General Partner and the Initial Limited Partner are parties to that certain
Agreement of Limited Partnership dated September 20, 2006 and amended as of November 18, 2008 (the
“Agreement”);

WHEREAS, pursuant to Section 2.2 of the Agreement, the General Partner, acting in its sole and
absolute discretion without the Consent of any Limited Partner, may change the name of the
Partnership;

WHEREAS, the General Partner desires to amend the Agreement as herein provided; and

WHEREAS, the Agreement, as amended by this Amendment shall be binding upon all Persons now or
at any time hereafter who are Partners;

NOW, THEREFORE, BE IT RESOLVED, that the General Partner hereby amends the Agreement as
follows:

1. Organizational Matters. Section 2.2 of the Agreement shall be deleted in its entirety
and replaced with the following:

2.2 Name

The name of the Partnership is Healthcare Trust of America Holdings, LP. The
Partnership’s business may be conducted under such name or under any other name or names
deemed advisable by the General Partner, including the name of the General Partner or any
Affiliate thereof. The words “Limited Partnership,” “LP,” “Ltd.” or similar words or
letters shall be included in the Partnership’s name where necessary for the purposes of
complying with the laws of any jurisdiction that so requires. The General Partner, acting
in its sole and absolute discretion without the Consent of any Limited Partner, may change
the name of the Partnership. The General Partner shall notify the Limited Partners of any
such name change in the next regular communication to the Limited Partners.

2. Applicable Law. This Amendment shall be construed and enforced in accordance with and
governed by the laws of the State of Delaware, without regard to the principles of conflicts of
laws thereof.

3. Invalidity of Provisions. If any provision of this Amendment is or becomes invalid,
illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining
provisions contained herein shall not be affected thereby.

4. Entire Agreement. The Agreement, as amended by this Amendment, contains the entire
understanding and agreement among the Partners with respect to the subject matter hereof and
supersedes any other prior written or oral understandings or agreements among them with respect
thereto.

[SIGNATURE PAGE FOLLOWS]

IN WITNESS WHEREOF, the parties hereto have executed and delivered this Amendment No. 2 to
Agreement of Limited Partnership as of the date and year first above written.

GENERAL PARTNER:

Healthcare Trust of America, Inc.

By:       /s/ Scott D. Peters      

Scott D. Peters

Chief Executive Officer and PresidentEX-10.2

Exhibit 10.2

SECOND AMENDMENT TO AGREEMENT OF SALE AND PURCHASE

THIS SECOND AMENDMENT TO AGREEMENT OF SALE AND PURCHASE (this “Amendment”) is made and entered
into as of this 21st day of August, 2009 by and between Greenville Hospital System, a political
subdivision organized under the laws of South Carolina and Board of Trustees of Greenville Hospital
System (aka, The Board of Trustees of The Greenville Hospital System) (collectively,
“GHS”), Greenville Health Corporation, Inc. (“GHC”), a South Carolina corporation
and GHC Health Resources, Inc. (“GHR”), a South Carolina corporation, all having an address
at 701 Grove Road, Greenville, SC 29605 (collectively the “Seller”), and HTA — Greenville,
LLC, a Delaware limited liability company, having an address at 16427 N. Scottsdale Road, Suite
440, Scottsdale, Arizona 85254 (“Buyer”). Seller and Buyer are each individually
referred to herein as a “Party” and collectively as the “Parties”.

R E C I T A L S:

A. Seller and Buyer entered into that certain Agreement of Sale and Purchase as of July 15,
2009 (as amended by that certain First Amendment to Agreement of Sale and Purchase, executed by
Buyer and Seller as of August 14, 2009, the “Agreement of Sale”).

B. Seller and Buyer desire to enter into this Amendment as described herein.

NOW, THEREFORE, in consideration of the terms, conditions and covenants contained herein, and
of other good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, Seller and Buyer agree as follows:

1. Satisfaction of Due Diligence. Pursuant to this Amendment, Buyer hereby confirms,
and Seller agrees, that Buyer has satisfied its due diligence review, subject to the following:

a. Title and Survey. All of Buyer’s rights, as more particularly set forth in Section
5 of the Agreement of Sale, with respect to review and objection of any title and survey matters
with respect to the Properties.

b. Geotechnical Confirmation. Confirmation and approval of Buyer’s ongoing
geotechnical review and examination of the Properties.

c. Board Approval. Final approval of the transaction contemplated by the Agreement of
Sale by the Board of Directors of Buyer.

d. Third Amendment to Agreement of Sale. Execution by Buyer and Seller of the Third
Amendment to Agreement of Purchase and Sale, a form of which has been previously sent to and
approved by Seller’s counsel.

The Parties hereby agree that the Due Diligence Period shall be deemed extended as set forth
herein, and Buyer shall have until 5:00 p.m. (Pacific Time) on Wednesday, August 26 to complete and
approve each of the foregoing items (except with respect to item (a) above which shall remain
subject to the time periods set forth in Section 5 of the Agreement of Sale).

2. Settlement. The first sentence of Section 3(a) of the Agreement of Sale is hereby
deleted in its entirety and replaced with the following:

(a) Settlement. The payment of the balance of the Purchase Price,
the transfer of title to the Property, and the satisfaction of all other terms and
conditions of this Agreement (“Settlement”) shall occur on September 4,
2009 (the “Closing Date”) or on such earlier date as Buyer and Seller may
mutually agree, at the offices of Haynsworth Sinkler Boyd, P.A. at 10:00 a.m. (the
“Closing Office”) with a representative from Parker Poe Adams & Bernstein,
LLP (“Buyer’s Local Counsel”) and/or Cox, Castle & Nicholson, LLP
(“Buyer’s Counsel”) present at the Closing Office, consistent with the
terms, conditions and requirements of this Agreement.

3. Due Diligence Amendment. During its Due Diligence Period Buyer has identified and
provided Seller with notice of a number of items (“Items”) set forth in Exhibit A which Buyer has
determined, through Due Diligence, need to be addressed and either replaced or repaired.

In that regard, Buyer and Seller agree as follows: (1) Seller agrees to pay for repairing and/or
replacing the roofs of the buildings as set forth on Exhibit A; and (2) Buyer and Seller will
mutually agree within six (6) months of Settlement on whether and/or when the repair or replacement
of the remaining Items will be performed; Seller will pay the cost of agreed upon Items.

The parties further agree that they will work cooperatively together to coordinate a
repair/replacement program for the agreed upon Items so that such Items are timely and properly
dealt with.

4. Reaffirmation. Except as modified by this Amendment, Seller and Buyer hereby
reaffirm all terms, covenants and conditions contained in the Agreement of Sale. The Parties agree
that except as modified herein, all other terms of the Agreement of Sale shall remain in full force
and effect. In the event of any conflict between the provisions of this Amendment and the
provisions of the Agreement of Sale, the provisions of this Amendment shall control. Whether or
not specifically amended by this Amendment, all of the terms and provisions of the Agreement of
Sale are hereby amended to the extent necessary to give effect to the purpose and intent of this
Amendment.

5. Counterparts. This Amendment may be executed in several counterparts, each of
which shall be deemed an original, and all of such counterparts together shall constitute one and
the same instrument.

6. Distribution. Counterparts to this Amendment may be executed and delivered by
facsimile or other electronic transmission, and for purposes of this Amendment, signatures so
transmitted shall be deemed to be original signatures.

[SIGNATURE PAGE FOLLOWS]

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IN WITNESS WHEREOF, the Parties have executed this Amendment as of the day, month and year
first written above.

SELLER:

GREENVILLE HOSPITAL SYSTEM,

a political subdivision organized under the laws
of South Carolina

By: /s/ Susan J. Bichel

Name: Susan J. Bichel

Title: Vice President and CFO

BOARD OF TRUSTEES OF GREENVILLE HOSPITAL SYSTEM
(aka THE BOARD OF TRUSTEES OF THE GREENVILLE
HOSPITAL SYSTEM)

By: /s/ Susan J. Bichel

Name: Susan J. Bichel

Title: Vice President and CFO

GREENVILLE HEALTH CORPORATION

a South Carolina corporation

By: /s/ Susan J. Bichel

Name: Susan J. Bichel

Title: Secretary/Treasurer

GHC HEALTH RESOURCES, INC.,

a South Carolina corporation

By: /s/ Susan J. Bichel

Name: Susan J. Bichel

Title: Secretary/Treasurer

BUYER:

HTA – GREENVILLE, LLC,

a Delaware limited liability company

By: /s/ Scott D. Peters

Name:

Title:       

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