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Exhibit 10.12  

***Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

Under 17 C.F.R. Sections 200.80(b)(4),

200.83 and 230.406.  

  
 

    COLLABORATIVE RESEARCH    
    
    AND    
    
    LICENSE AGREEMENT    
    
    BETWEEN    
    
    SENOMYX, INC.    
    
    AND    
    
    AURORA BIOSCIENCES CORPORATION    

 
COLLABORATIVE RESEARCH AND LICENSE AGREEMENT  

        THIS AGREEMENT is entered into as of the Effective Date by and between SENOMYX, INC., a Delaware corporation having offices at 11099 North Torrey
Pines Road, La Jolla, California 92037 ("Senomyx"), and AURORA BIOSCIENCES CORPORATION, a Delaware corporation having offices at 11010 Torreyana Road, San Diego, California 92121
("Aurora"). 

RECITALS 

        WHEREAS,
Senomyx conducts research in the field of chemosensation, an objective of which is to discover potential biological targets and develop assays for use in taste, olfaction and
pheromone detection; and 

        WHEREAS,
Aurora develops assays and screening systems and related biologies/chemistries used therein; and 

        WHEREAS,
Senomyx and Aurora are interested in collaborating in the development of assays and screening systems to identify and develop small molecules for use in consumer products and
therapeutics. 

AGREEMENT 

        NOW,
THEREFORE, in consideration of the foregoing premises and of the covenants, representations and agreements set forth below, the parties hereby agree as follows: 

1.     DEFINITIONS  

        As used herein, the following terms shall have the following meanings: 

        "Agreement"
means this agreement, together with all exhibits attached hereto, as the same may be amended or supplemented from time to time hereafter by a written agreement duly executed
by authorized representatives of each party. 

        "Assay
Platform" means one or more cell lines or biochemical screens developed under the collaboration by Aurora and/or Senomyx for Targets, as described in a Work Plan. 

        "Aurora
Compound" means any chemical Controlled by Aurora. 

        "Aurora
Know-How" means all Know-How related to the Assay Platforms or Aurora Reporters, which is not covered by the Aurora Patent Rights, but is necessary to
practice the licenses granted under this Agreement, and which is Controlled by Aurora as of the Effective Date or developed by Aurora in the course of performing activities under a Work Plan. 

        "Aurora
Patent Rights" mean all Patent Rights that claim Assay Platforms or Aurora Reporters, which are necessary to practice the licenses granted under this Agreement, and which are
Controlled by Aurora as of the Effective Date or developed by Aurora in the course of performing activities under a Work Plan, but excluding any Joint Patent Rights. The Aurora Patent Rights as of the
Effective Date are set forth on Exhibit 1. 

        "Aurora
Reporter" means any of the reporters described in Exhibit 3. 

        "Aurora
Screening Program" has the meaning set forth in Section 2.4. 

        "Aurora
Technology" means Aurora Patent Rights and Aurora Know-How. 

        "Collaborative
Period" means the period beginning on the Effective Date and ending three (3) years thereafter, unless terminated earlier in accordance with Section 10.2,
10.3 or 10.4. 

        "Compound
Supply" has the meaning set forth in Section 2.4.1. 

2

 

        "Confidential
Information" means all information, Inventions and Know-How disclosed by one party to the other party pursuant to this Agreement, including, without limitation,
information and material (whether or not patentable) regarding technology, products, research, development, manufacturing, marketing, finances, personnel or other business information or objectives
which is designated as confidential in writing by the disclosing party, whether by letter or by the use of an appropriate stamp or legend, prior to or at the time any such material, trade secret or
other information is disclosed by the disclosing party to the other party. Notwithstanding the foregoing to the contrary, Know-How or other information which is orally, electronically or
visually disclosed by a party, or is disclosed in writing without an appropriate letter, stamp or legend, shall constitute Confidential Information of a party if the disclosing party, within thirty
(30) days after such disclosure, delivers to the other party a written document or documents describing the Know-How or other information and referencing the place and date of such
oral, visual, electronic or written disclosure and the names of the persons to whom such disclosure was made. 

        "Control"
or "Controlled" means, with respect to intellectual property, possession by a party, as of the Effective Date or during the Collaborative Period, of the ability to grant a
license or sublicense in accordance with the terms of this Agreement, without violating the terms of any agreement by such party with any Third Party that is in effect on the Effective Date. 

        "Derivative"
means a chemical that has a structure based on data derived from a Hit; provided that such chemical has the same modulating effect as such Hit when tested in the same assay
which was used to identify such Hit. It is understood that Senomyx will test chemicals having a structure based on data derived from a Hit in the same assay which was used to identify such Hit. It is
further understood that a Derivative includes a chemical derived from another Derivative. 

        "Development
Compound" means any Hit or Derivative selected for development as a Product and for which studies necessary for an IND filing (e.g., good laboratory practice safety studies)
have been initiated. 

        "Effective
Date" means the date that this Agreement is signed by the last party to sign below. 

        "Excluded
Compounds" has the meaning set forth in Section 2.4.4. 

        "FDA"
means the United States Food and Drug Administration, or any successor agency having regulatory jurisdiction over the manufacture, distribution and sale of drugs in the United
States or the equivalent governmental agency in any other jurisdiction. 

        "Field I"
means [***]. 

        "Field II"
means [***]. 

        "Full
Time Equivalent" or "FTE" means the full time equivalent of one (1) Aurora scientist, based on a minimum of  [***] hours per year. 

        "GAAP"
means generally accepted accounting principles consistently applied. 

        "Hit"
means any chemical (e.g. a small molecule or protein) identified or discovered in the course of screening such chemical by or for Senomyx using an assay which incorporates or uses
the Aurora Technology or an Aurora Reporter. 

        "IND"
means an Investigational New Drug Application filed with the FDA to commence human clinical testing of a Product. 

        "Internal
Research" means self-funded or Third Party funded biological research conducted by Senomyx at the premises of Senomyx, including the development of screens, the
performance of screening, the cloning of genes and the validation of Targets. Notwithstanding the foregoing, Internal Research does not include use of an Aurora Reporter or the Aurora Technology in a
promoterless, 

3

 

gene
trap, enhancer trap or promoter trap vector for integration into a mammalian genome using non-homologous recombination integration methods (e.g. random integration). 

        "Invention"
means any new and useful process, method, or composition of matter, or improvement thereto, whether or not patentable. 

        "Joint
Invention" has the meaning set forth in Section 4.3.4. 

        "Joint
Patent Rights" means all Patent Rights containing one or more claims to a Joint Invention. 

        "Know-How"
means information and data, whether or not patentable, which is not generally known to the public, including, without limitation, designs, concepts, formulae,
techniques, practices, processes, methods, knowledge, skill, experience, expertise, technical information and data, including pharmacological, toxicological and clinical test data, analytical and
quality control data, patent and legal data or marketing, sales and manufacturing data. 

        "Licensee"
means any Third Party to whom Senomyx or any of its Affiliates grants a license, sublicense or other right to manufacture, use, sell, offer for sale, distribute and/or import
one or more Products or Development Compounds. 

        "Licensor"
means any Third Party that grants Senomyx or any of its Affiliates a license, sublicense or other right to manufacture, use, sell, offer for sale, distribute and/or import one
or more Products or Development Compounds. 

        "Materials"
mean any reagents, promoters, enhancers, vectors, plasmids, genes, polynucleotides, cell lines, proteins and fragments thereof, peptides, antigens, antibodies, antagonists,
agonists, inhibitors, compounds and chemicals. 

        "NDA"
means a New Drug Application or the equivalent, and all supplements pursuant to the requirements of the FDA, including all documents, data and other information concerning Products
which are necessary for FDA approval to market a Product, or the equivalent governmental approval in any other country. 

        "Net
Sales" means, with respect to a Product, the gross amount invoiced by Senomyx, its Affiliates, Licensors, Licensees, and/or permitted sublicensees on sales or other transfers of the
Product, less the following items: 

	(i)
	allowances
(actually paid and limited to rejections, returns, and prompt payment and volume discounts granted to customers of Products, whether in cash or Products in
lieu of cash);

	(ii)
	freight,
transport packing, insurance charges associated with transportation; and

	(iii)
	taxes,
tariff or import/export duties based on sales when included in gross sales, but not value-added taxes or taxes assessed on income derived from such sales. 

        Where
Senomyx distributes to an Affiliate, Licensor, Licensee, a joint venture or permitted sublicensees for end use by such Affiliate, Licensor, Licensee, joint venture or permitted
sublicensees then such distribution will be considered a sale at list price normally charged to independent Third Parties and Aurora will be entitled to collect a royalty on such sale in accordance
with Section 3. Such amounts shall be determined from the books and records of Senomyx, its Affiliates, Licensor, Licensees, joint venture and/or its permitted sublicensees, maintained in
accordance with GAAP. 

        "Patent
Rights" means all rights associated with all United States or foreign (including regional authorities such as the European Patent Office) regular or provisional patents or patent
applications, including any continuation, continuation-in-part, or division thereof or any substitute application therefor or equivalent thereof, and any patent issuing
thereon, including any reissue, reexamination or extension thereof and any confirmation patent or registration patent or patent of additions based on any such patent. 

4

 

        "Phase II
Clinical Trial" means studies in humans of the safety, dose ranging and efficacy of a Product in Field I. 

        "Product"
means any composition of matter which incorporates a Development Compound or is manufactured using the Aurora Technology or an Aurora Reporter. 

        "Royalty
Term" means, [***]

        "Senomyx
Compound" means any chemical Controlled by Senomyx. 

        "Senomyx
Know-How" means all Know-How related to the Assay Platforms (including the Targets), which is not covered by the Senomyx Patent Rights, but is necessary
to accomplish the activities to be conducted under this Agreement, and which is Controlled by Senomyx as of the Effective Date or developed by Senomyx in the course of performing activities under a
Work Plan. 

        "Senomyx
Patent Rights" means all Patent Rights which are necessary to accomplish the activities to be conducted under this Agreement, and which are Controlled by Senomyx as of the
Effective Date or developed by Senomyx in the course of performing activities under a Work Plan, but excluding any Joint Patent Rights. The Senomyx Patent Rights as of the Effective Date are set forth
on Exhibit 2. 

        "Senomyx
Technology" means Senomyx Patent Rights and Senomyx Know-How. 

        "Steering
Committee" has the meaning set forth in Section 2.1. 

        "Stock
Purchase Agreement" means the stock purchase agreement set forth on Exhibit 4. 

        "Target"
means a target identified in taste, olfaction and pheromone detection and listed on Exhibit 5, as modified from time to time by the Steering Committee as provided under
Section 2.2. 

        "Term"
has the meaning set forth in Section 10.1. 

        "Third
Party" means any person or entity other than Aurora or Senomyx. 

        "Tracking
Record" has the meaning set forth in Section 5.5.2. 

        "Ultra-High
Throughput Screening System" or "UHTSSTM System" means a technology platform sold by Aurora that has the capability of screening over 100,000 compounds
per day, accessed from a store of compounds, with the additional ability to capture and store large volumes of information. 

        "Validation"
has the meaning set forth in Section 2.3.3. 

        "Validation
Criteria" means the parameters, standard and results established by the Steering Committee for each Assay Platform based on the performance criteria provided in
Exhibit 6. 

        "Voltage
Ion Probe Reader" or "VIPR" means the instrumentation described in Exhibit 7. 

        "Voltage
Ion Probe Reader II" or "VIPR II" means the instrumentation described in Exhibit 7. 

        "Work
Plan" has the meaning set forth in Section 2.3.1. 

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   2.     COLLABORATION, ASSAY PLATFORM DEVELOPMENT AND SCREENING PROGRAM  

        2.1    Steering Committee.    No later than ten (10) days after the Effective Date, the parties shall establish
a joint steering committee (the "Steering Committee"). The Steering Committee shall prepare and manage each Work Plan. The Steering Committee shall consist of two (2) representatives designated
by Senomyx and two (2) representatives designated by Aurora. Each representative to the Steering Committee will have one vote. The Steering Committee will meet no later than thirty
(30) days after the Effective Date and at least four (4) times per year using mutually agreed upon meeting locations and formats including tele- and video-conferencing. On an
alternating basis, one party shall promptly prepare and deliver to the members of the Steering Committee minutes of such meetings for review and approval of both parties. Aurora and Senomyx shall flip
a coin to determine who shall prepare the minutes for the first Steering Committee meeting. Decisions in the Steering Committee will be made by unanimous vote, at a meeting where all four
(4) voting representatives are present. All unresolved disputes will be settled in accordance with Section 11.13, or as otherwise mutually agreed upon in writing. 

        2.2    Target Selection.    The Steering Committee may, in its sole discretion, add and/or remove Targets from the
list of Targets set forth on Exhibit 5. 

        2.3    Assay Platform Program.    

        2.3.1    Work Plan.    The Steering Committee will prepare and agree
upon a written plan for each Assay Platform (a "Work Plan"), which sets forth the respective responsibilities of the parties for the development of each Assay Platform. Each Work Plan will contain a
description of the specific deliverables and documentation to be produced, any Aurora Reporter to be used, the dates by which such activities are expected to be accomplished by the parties, and
Validation Criteria for each Assay Platform. 

        2.3.2    Assay Platform Development.    Within ten (10) days
following the approval of each Work Plan, Aurora will commence the development of the applicable Assay Platform using2.3.3 reasonable efforts, consistent with commercial business practices, and using
the resources provided under Section 3.1. All work under a Work Plan shall be performed in accordance with the provisions of this Agreement. 

        2.3.3    Validation of Assay Platforms.    When Aurora completes the
development of an Assay Platform, a written report describing the Assay Platform and the data demonstrating compliance with the Work Plan, including the Validation Criteria, shall be provided by
Aurora to the Steering Committee. The Steering Committee will either approve the report and accept each Assay Platform according to the Validation Criteria ("Validation") or decide on additional work,
if any, necessary for Validation. Within thirty (30) days of such Validation of an Assay Platform developed by Aurora, and as requested in writing by Senomyx, Aurora shall transfer such Assay
Platform to Senomyx. 

        2.4    Screening by Aurora.    During the Collaborative Period and for  [***] thereafter, Senomyx may purchase from Aurora contract screening pursuant to Section 3.3. Aurora will screen Aurora
Compounds or Senomyx Compounds as determined by the Steering Committee and provide re-tests of putative Hits, and determination of crude EC50s or IC50s as determined by the Steering
Committee (an "Aurora Screening Program"). 

        2.4.1    Senomyx Compounds.    Senomyx shall, at its expense, supply
Aurora with Senomyx Compounds for each Aurora Screening Program. Any Senomyx Compounds supplied by Senomyx for use in an Aurora Screening Program will be  [***], or another format mutually agreed to in
writing by the parties (the "Compound Supply"). The quantities needed for each
screen will be specified in writing in the Work Plan. Aurora agrees not to transfer the Compound Supply to any Third Party or to use it for any purpose other than developing or screening Assay
Platforms 

6

 

without
Senomyx's prior written consent. Aurora will return to Senomyx any unused Compound Supply. 

        2.4.2    Aurora Compound Supply.    Aurora will make available to
Senomyx up to five hundred thousand (500,000) Aurora Compounds for use in Aurora Screening Programs. The Steering Committee will select, on an entire microtiter plate-by-entire
microtiter plate basis, Aurora Compounds for use in an Aurora Screening Program. Information concerning Aurora Compounds shall be owned exclusively by Aurora and shall be treated as Confidential
Information of Aurora hereunder. 

        2.4.3    Screening Program Reports.    During the course of an Aurora
Screening Program, individuals from Senomyx and Aurora, appointed by the Steering Committee, will discuss and review monthly, if not more frequently, the progress and any issues relating to such
Aurora Screening Program. During the Collaboration Period, the Steering Committee will review data and prepare summary quarterly reports for each Aurora Screening Program in progress at that time.
Each progress report shall provide a written update of work performed, any Hits identified, and all available supporting electronic data. 

        2.4.4    Designation of Excluded Compounds.    At least thirty
(30) days prior to commencement of any Aurora Screening Program, Senomyx shall submit to Aurora in writing a list of the Excluded Compounds designated for a particular screen to be used as a
positive control in such screens, which list is subject to the approval of the Steering Committee, which approval shall not be unreasonably withheld. 

        2.4.5    Ownership of Results and Data.    All results and data
generated from screening the Compound Supply by or for Senomyx under this Agreement shall be owned exclusively by Senomyx and shall be treated as Senomyx Confidential Information hereunder. Aurora
will not provide to a Third Party the Materials provided by Senomyx to Aurora hereunder. 

        2.5    Development of Products.    Senomyx will be responsible, at Senomyx's expense, for all formulation and
regulatory approval of Products arising out of this Agreement. Senomyx shall use reasonable efforts, consistent with commercial business practices, to develop any Product, to perform all regulatory
activities relating to the manufacture, use or sale of any Product, and to commercialize and market any Product in any country. All regulatory filings made or filed by Senomyx for any Development
Compound or Product shall be owned solely by Senomyx. At Senomyx's request and expense, Aurora shall cooperate to the extent reasonably necessary to permit Senomyx to perform the foregoing activities. 

        2.6    Supply of VIPR and Option to Upgrade to VIPR II.    Within thirty (30) days after the Effective
Date, Aurora will deliver a VIPR to the Senomyx facility in La Jolla, California, or another Senomyx location mutually agreed upon by the parties, and within thirty (30) days of receipt of such
VIPR, Aurora shall install and commission it to demonstrate functionality as to the instrumentation specifications listed in Exhibit 7. On or before  [***], Senomyx shall have the option to exchange
the VIPR for a VIPR II by providing written notice to Aurora and making
the additional payment to Aurora in accordance with Section 3.9. Within [***] of receipt of such notice, Aurora will
deliver a VIPR II to the Senomyx facility in La Jolla, California, or another Senomyx location mutually agreed by the parties, and within  [***] of receipt of such VIPR II, Aurora shall
(i) install and commission the VIPR II to demonstrate
functionality as to the instrumentation specification listed in Exhibit 7, and (ii) return the VIPR to Aurora. Subject to payment of the warranty fee set forth in Section 3.9,
Aurora will provide to Senomyx Aurora's then-current standard warranty as described on Exhibit 7 for such VIPR or VIPR II for a period of  [***] [***] from the date of delivery of the VIPR,
provided that such warranty may be extended as
provided for in Section 3.9. 

7

 

3.     FINANCIAL TERMS  

        3.1    Annual Research Support.    Each year during the Collaborative Period, Senomyx shall pay Aurora for 
[***] FTEs at an annual rate of [***] per FTE. These
payments shall be made in advance on an equal quarterly basis. The first payment shall be made within ten (10) business days following the Effective Date. These payments are inclusive of
overhead, labor, and supplies; provided, however, that in any given year, a portion of these payments may be allocated to cover the cost of high
throughput screening of Senomyx Compounds by Aurora [***] with a commensurate reduction in the allocation of payments for FTEs.
These payments shall not cover the cost associated with providing the Compound Supply to Aurora or other unanticipated materials, as agreed to by the parties in advance in writing, or the costs of
high throughput screening for over [***]. Additional funding, if any, shall be proposed by the Steering Committee and agreed to
by the parties in advance in writing. 

        3.2    Validation Payments.    Senomyx will pay to Aurora the following non-creditable,
non-refundable milestone payments within thirty (30) days following achievement of the following milestone events: 

	Milestone
 
	 	Payment

	[***]	 	 
	[***]	 	 
	[***]	 	 

        3.3    Screening by Aurora.    Aurora will screen Aurora Compounds and Senomyx Compounds under each Aurora Screening
Program in accordance with Section 2.4. Senomyx will pay Aurora for such screening within thirty (30) days after the completion of such screening. For screening conducted by Aurora using
its ultra-high throughput screening system, Senomyx will pay Aurora [***], with  [***]. For screening conducted by Aurora using its VIPR, Senomyx will pay
Aurora  [***], with [***]. The parties will negotiate in good
faith the payments to be made by Senomyx to Aurora for Aurora Compounds which may be licensed to Senomyx hereunder, including, without limitation,  [***]. 

        3.4    Milestones and Royalties.    

        3.4.1    Milestone Payments for Field I.    Senomyx will pay to
Aurora the following non-creditable, non-refundable milestone payments for each Product in Field I within thirty (30) days following achievement of the following
milestone events: 

	Milestone
 
	 	Payment

	[***]	 	 
	[***]	 	 
	[***]	 	 
	[***]	 	 

        The
foregoing milestones apply only to the first chemical developed for each Product. Under no circumstances shall Senomyx be obligated to pay any of the foregoing payments to Aurora
more than once for each Product. 

        3.4.2    Royalty on Net Sales.    Senomyx will pay to Aurora a royalty
equal to [***] of Net Sales for each Product in Field I during the Royalty Term. 

        3.4.3    Trade Secret Milestones and Royalty.    The parties
acknowledge that the principal value contributed by Aurora under this Agreement is the enhanced probability of identifying leads for Products, such as consumer products enhancing taste and olfaction
(or other products having commercial value), and the potential to generate multiple leads, either or both of which the parties reasonably believe will lessen the time required to bring products to
market and increase the efficiency of discovery and development processes and technologies. Additionally, the parties 

8

 

acknowledge
that Aurora may not Control Patent Rights covering the manufacture, sale, use or importation of a particular Development Compound or Product. Senomyx acknowledges and agrees that the value
it receives hereunder is in the access and use of a Assay Platform or Aurora Reporter. Accordingly, Senomyx agrees to pay [***]. 

        3.5    Supply of Aurora Reporters.    Within  [***] of a written
purchase order from Senomyx, Aurora will supply to Senomyx Materials pertaining to the Aurora Reporters.
Senomyx will be charged for all Materials so delivered at Aurora's then-current list price less  [***]; provided,
however, that
Senomyx will purchase [***], as defined on Exhibit 3, on or before  [***], at a price of  [***]. Senomyx will pay for all Materials so ordered within thirty (30) days after delivery of such Materials to Senomyx. 

        3.6    Aurora Stock Purchase.    Within ten (10) days following the Effective Date, Aurora will purchase
four million eight hundred thousand dollars ($4,800,000) of Senomyx Series C preferred stock under terms and conditions consistent with its most recent round of financing and pursuant to
the Stock Purchase Agreement at a price of four dollars, eighty cents ($4.80) per share. 

        3.7    License Fee.    In partial consideration for the licenses granted under Section 4.1, Senomyx will pay to
Aurora a non-creditable, non-refundable license fee of [***] within ten (10) days following the
Effective Date. 

        3.8    Purchase of VIPR and upgrade to VIPR II.    In consideration for the VIPR, Senomyx shall pay to Aurora
 [***] payable in two equal installments:
(i) [***] within  [***] after delivery of such VIPR to Senomyx, and
(ii) [***] within  [***] after the commissioning of such VIPR at Senomyx. If Senomyx exercises its
option to exchange the VIPR for a
VIPR II, then Senomyx will pay to Aurora an additional payment of [***] within  [***] after the commissioning of such VIPR II at Senomyx. In
consideration for the  [***] VIPR warranty provided under Section 2.6, Senomyx shall pay to Aurora a warranty fee of  [***] within [***] after the first anniversary of the
date of delivery of the VIPR to Senomyx. Senomyx may, at its sole discretion, extend the warranty on the VIPR or the VIPR II beyond
such [***] period for [***] per year payable on  [***] thereafter. 

4.     LICENSES; INTELLECTUAL PROPERTY RIGHTS  

        4.1    Grant of Rights from Aurora to Senomyx.    

        4.1.1    Non-Exclusive License to use Aurora Technology in Assay
Platforms.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Assay Platforms solely to conduct Internal Research to
develop screens for the Targets and to screen the Targets (i) to identify, discover and profile compounds, and (ii) to make, have made, use, sell, offer for sale and import compounds or
Products identified or discovered with activity against such Targets in the Assay Platforms. 

        4.1.2    Exclusive License to use Aurora Technology in Assay Platforms in
Field II.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Assay Platforms solely to conduct Internal Research to develop screens
for the Targets and to screen the Targets (i) to identify, discover and profile compounds in Field II, and (ii) to make, have made, use, sell, offer for sale and import compounds
or Products identified or discovered with activity against such Targets in the Assay Platforms in Field II. 

        4.1.3    Non-Exclusive License to use Aurora Reporters for Internal Research of
Targets.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Aurora Reporters solely to 

9

 

conduct
Internal Research on the Targets (i) to identify, discover and profile compounds, and (ii) to make, have made, use, sell, offer for sale and import compounds or Products
identified or discovered with activity against such Targets. 

        4.1.4    Exclusive License to Use Aurora Reporters for Internal Research of Targets in
Field II.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Aurora Reporters solely to conduct Internal Research on the Targets
(i) to identify, discover and profile compounds in Field II, and (ii) to make, have made, use, sell, offer for sale and import compounds or Products identified or discovered with
activity against such Targets in Field II. 

        4.1.5    Non-Exclusive License to use VIPR and VIPR II for Internal Research of
Targets.    Subject to the terms and conditions of this Agreement, including the payment obligations set forth in Section 3.9, Aurora hereby grants to Senomyx
a non-transferable, except as provided in Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the
VIPR or VIPR II, if applicable, for Internal Research related to the Targets which shall commence upon the commissioning of the VIPR at Senomyx. 

        4.1.6    License Restrictions.    Except as expressly licensed in this
Section 4.1, Senomyx covenants not to use the Assay Platforms, Aurora Technology or Aurora Reporters for any purpose. Aurora will permit Senomyx to transfer Materials containing Aurora
Reporters or Aurora Technology to a Third Party under terms mutually agreed upon in writing by Aurora and Senomyx prior to such transfer; provided,
however, that such Third Party is a bona fide licensee of Aurora under the Aurora Patent Rights. 

        4.1.7    Exclusive License Exceptions.    

        4.1.7.1    Notwithstanding
anything contained herein to the contrary, the exclusive licenses granted by Aurora to Senomyx in this Section 4 are subject to all previous
licenses granted by Aurora under the Aurora Technology, which list of licensees, as of the Effective Date, includes, but is not limited to,  [***]. Additionally, Aurora will not be precluded by the grant
of such exclusive licenses from licensing the Aurora Technology
in Field II for use with the Targets to future licensees, but only when such license is granted in connection with the purchase of a UHTSSTM System from Aurora. Aurora will notify
Senomyx in writing if and when such a license is granted. 

        4.1.7.2    Notwithstanding
the exclusive licenses granted by Aurora to Senomyx in this Section 4, Aurora will not be precluded from selling and/or providing Aurora
Reporters to academic, government and other not-for-profit organizations. Aurora may grant licenses under the Aurora Technology to such not-for-profit
organizations to conduct research using the Aurora Reporters through material transfer agreements, shrink-wrap licenses or otherwise. 

        4.2    Grant of Rights from Senomyx to Aurora.    Senomyx hereby grants to Aurora a fully-paid,
non-transferable, except as provided in Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, to use the
Senomyx Technology solely to perform its obligations under this Agreement. Except as expressly licensed in this Section 4.2, Aurora covenants not to use the Senomyx Compounds or the Senomyx
Technology provided by Senomyx either for Internal Research or with Third Parties. 

        4.3    Ownership of Intellectual Property.    

        4.3.1    Transfer of Rights.    All rights not expressly licensed or
assigned herein by Senomyx are retained by Senomyx. All rights not expressly licensed or assigned herein by Aurora are retained by Aurora. Except as otherwise expressly provided in this Agreement,
nothing in this 

10

 

Agreement
is intended to convey or transfer ownership by either party to the other party of any right, title or interest in any Confidential Information, Patent Rights or Know-How
Controlled by a party. Except as expressly provided for in this Agreement, nothing in this Agreement shall be construed as a license or sublicense by either party to the other party of any rights in
any Patent Rights or Know-How Controlled by a party. 

        4.3.2    Senomyx Inventions.    Senomyx shall own all Inventions and
other Know-How made solely by its employees and agents, and all Patent Rights claiming such Inventions and other Know-How. Senomyx hereby irrevocably assigns to Aurora all
right, title and interest in and to any such Inventions and other Know-How that consist of improvements to an Aurora Reporter, the Aurora Technology or the Aurora Compounds, and all Patent
Rights claiming such Inventions and other Know-How, subject to the licenses granted to Senomyx pursuant to Section 4.1. In the event that Senomyx is legally unable to assign such
rights to Aurora, then Senomyx agrees either to waive the enforcement of such rights against Aurora and any sublicensees and assignees, or to grant Aurora an exclusive, irrevocable, perpetual,
worldwide, fully-paid license, with right to sublicense through multiple tiers of sublicense, to such rights. 

        4.3.3    Aurora Inventions.    Aurora shall own all Inventions and
other Know-How made solely by its employees and agents, and all Patent Rights claiming such Inventions and other Know-How. Aurora hereby irrevocably assigns to Senomyx all
right, title and interest in and to any such Inventions and other Know-How that consist of improvements to the Senomyx Technology or the Senomyx Compounds, and all Patent Rights claiming
such Inventions and other Know-How, subject to the license granted to Aurora pursuant to Section 4.2. In the event that Aurora is legally unable to assign such rights to Senomyx,
then Aurora agrees either to waive the enforcement of such rights against Senomyx and any sublicensees and assignees, or to grant Senomyx an exclusive, irrevocable, perpetual, worldwide,
fully-paid license, with right to sublicense through multiple tiers of sublicense, to such rights. 

        4.3.4    Joint Inventions.    During the Collaboration Period, all
Inventions conceived jointly by employees or agents of Senomyx and employees or agents of Aurora (the "Joint Inventions") and all Joint Patent
Rights shall be owned jointly by Aurora and Senomyx. Aurora hereby assigns to Senomyx all right, title and interest in and to any Joint Inventions that consist of improvements to the Senomyx
Technology or the Senomyx Compounds, and all Joint Patent Rights claiming such Joint Inventions, subject to the license granted to Aurora pursuant to Section 4.2. In the event that Aurora is
legally unable to assign such rights to Senomyx, then Aurora agrees either to waive the enforcement of such rights against Senomyx and any sublicensees and assignees, or to grant Senomyx an exclusive,
irrevocable, perpetual, worldwide, fully-paid license, with right to sublicense through multiple tiers of sublicense, to such rights. Senomyx hereby irrevocably assigns to Aurora all
right, title and interest in and to any Joint Inventions that consist of improvements to the Aurora Technology, the Aurora Reporters or the Aurora Compounds, and all Joint Patent Rights claiming such
Joint Inventions, subject to the licenses granted to Senomyx pursuant to Section 4.1. In the event that Senomyx is legally unable to assign such rights to Aurora, then Senomyx agrees either to
waive the enforcement of such rights against Aurora and any sublicensees and assignees, or to grant Aurora an exclusive, irrevocable, perpetual, worldwide, fully-paid license, with right
to sublicense through multiple tiers of sublicense, to such rights. 

        4.3.5    Other Inventions.    Any Inventions not included in
Sections 4.3.2, 4.3.3 or 4.3.4 shall be owned by their inventors. 

        4.3.6    Inventorship and Assignment.    Inventorship of patentable
inventions shall be determined by United States patent law. Senomyx and Aurora agree to execute all documentation necessary to perfect all assignments of Inventions, Know-How and Patent
Rights contemplated herein. 

11

   5.     PAYMENTS OF ROYALTIES, ACCOUNTING FOR ROYALTIES AND RECORDS  

        5.1    Payment and Reporting.    The royalties due under Section 3.4.2 shall be paid within thirty
(30) days after the end of each calendar quarter period in which such royalties are earned during the Royalty Term for each Product. With each such quarterly payment, Senomyx shall furnish to
Aurora a royalty statement in sufficient detail to permit confirmation of the accuracy of the royalty payment made, which sets forth on a country-by-country basis the relevant
sales information, including the total number of units of each such Product sold, Net Sales, the royalties payable in United States dollars, the method used to calculate the royalty, the exchange rate
used and other information employed to calculate Net Sales for such Product. 

        5.2    Currency of Payment.    All payments to be made under this Agreement, including the royalties payable to Aurora
by Senomyx, shall be paid in United States dollars by wire transfer or other mutually acceptable means to a bank account designated by Aurora. With respect to each quarter, for countries other than
the United States, whenever conversion of payments form any foreign currency shall be required, such conversion shall be made at the rate of exchange reported in The Wall
Street Journal on the last business day of the applicable reporting period. 

        5.3    Taxes Withheld.    Any income or other tax that Senomyx or any of its Affiliates, Licensees or Licensees is
required by a government agency to withhold and pay on behalf of Aurora with respect to the royalties payable under this Agreement shall be deducted from and offset against such royalties prior to
remittance to Aurora; provided, however, that in regard to any tax so deducted, Senomyx shall give or cause to be given to Aurora such assistance as may
reasonably be necessary to enable Aurora to claim exemption therefrom or credit therefor, and in each case shall promptly furnish to Aurora proper evidence of the taxes paid on Aurora's behalf. 

        5.4    Records.    

        5.4.1    Net Sales and Royalty Calculations.    During the Royalty
Term and for a period of three (3) years thereafter, Senomyx shall keep complete and accurate records of sales and all other information necessary to calculate Net Sales of each Product in
sufficient detail to allow the accrued royalties to be determined accurately in accordance with GAAP. Aurora, with reasonable written notice to Senomyx,
shall have the right to cause a nationally recognized independent, certified public accountant to audit such records at the place or places of business where such records are customarily kept in order
to verify the accuracy of the reports of Net Sales and royalty payments made by Senomyx hereunder. Such accountant shall execute a confidentiality agreement prior to entering Senomyx's premises,
obligating such accountant to keep all information disclosed to it confidential and shall only be permitted to disclose to Aurora the extent of any discrepancy between royalty payments made by Senomyx
hereunder and the actual royalty required to be so paid. Aurora shall bear the full cost of such audit, unless such audit discloses a variance of more than five percent (5%) from the amount of the
royalties due under this Agreement, in which event, Senomyx shall bear the full cost of such audit. Aurora agrees not to disclose Confidential Information concerning royalty payments and reports, and
all information learned in the course of any audit or inspection, except to the extent necessary for Aurora to reveal such information in order to enforce its rights under this Agreement or if
disclosure is required by law. 

        5.4.2    Tracking Records.    The chemicals, screens and Targets
tested using an Assay Platform, Aurora Technology or Aurora Reporter will be recorded and stored by Senomyx using its customary means in a computer searchable database on a storage device. The
information stored will include the Target, screen type, the concentration, structure and activity of the chemical tested, and date of testing in a format mutually agreed upon in writing by the
parties. Records of any Hits, Derivatives, Aurora Compounds, Senomyx Compounds or other chemicals subjected to additional screening will be stored by Senomyx in a computer searchable file or database
that will be separate from other Senomyx data not related to an Assay Platform, Aurora Technology or 

12

 

Aurora
Reporter. Upon written request by Aurora, Senomyx will create an annual written report of Hits, Derivatives, Aurora Compounds, Senomyx Compounds or other chemicals subjected to additional
screening, in vivo testing, computer modeling, or medicinal chemistry to be accessible only by an independent consultant. All the records described in
this Section 5.4.2 are collectively referred to as tracking records (the "Tracking Records"). Senomyx will permit a Third Party appointed by Aurora and reasonably agreed to by Senomyx, and
subject to a confidential relationship with Senomyx, to inspect the Tracking Records once per year or upon reasonable request by Aurora for the sole purpose of determining the attainment of a
milestone or royalty under Section 3.4. The Tracking Records shall be securely retained for no less than five (5) years from the last use of an Assay Platform, Aurora Technology or
Aurora Reporter. When a compound, such as a Hit, Derivative or Development Compound, is selected for a good laboratory practice safety or toxicology study, Senomyx will disclose the compound to Aurora
under strict confidentiality. Upon reasonable request by Aurora, and at a minimum once per year, Senomyx will provide Aurora with a summary of the status of Development Compounds and Products that may
be used to calculate royalties or milestones hereunder. 

6.     INTELLECTUAL PROPERTY ENFORCEMENT AND DEFENSE OF CLAIMS  

        6.1    Intellectual Property Enforcement.    Each party shall have the right, but not the obligation, to bring
proceedings against any Third Party for the inappropriate use, including patent infringement, of Patent Rights solely Controlled by it, at its own risk and expense. If either party brings such an
action, such party shall be entitled to control such action, hire and retain counsel, make decisions, settle on any terms, and retain any and all awards or damages obtained in any such proceeding. At
the request and expense of either party, the other party shall give the requesting party all reasonable assistance required to file and conduct any such proceeding. 

        6.2    Defense of Infringement Claims for Aurora Technology.    Senomyx will cooperate with Aurora, at Aurora's
expense, in the defense of any suit, action or proceeding against Aurora alleging the infringement of the intellectual property rights of a Third Party by reason of Aurora's use of any Aurora
Technology or any Aurora Reporter in performing its obligations under this Agreement. Aurora shall notify Senomyx promptly in writing of the commencement of any such suit, action, proceeding or claim
of infringement. Senomyx shall give to Aurora full and sole authority, information and assistance necessary to defend, hire counsel, make decisions or settle on any terms any such suit, action or
proceeding, and Senomyx shall execute all documents, provide pertinent records, and take all other actions, including requiring persons within its control to give testimony, which may be reasonably
required in connection with the defense or settlement of such litigation. 

        6.3    Defense of Infringement Claims for Products.    Aurora will cooperate with Senomyx, at Senomyx's expense, in
the defense of any suit, action or proceeding against Senomyx and Senomyx's Affiliates or Aurora alleging the infringement of the intellectual property rights of a Third Party by reason of the
manufacture, use or sale of any Product. Each party shall give the other party prompt written notice of the commencement of any such suit, action, proceeding or claim of infringement. At the request
and expense of Senomyx, Aurora shall give Senomyx full and sole authority, information and assistance necessary to defend, hire counsel, make decisions or settle on any terms any such suit, action or
proceeding and Aurora shall execute all documents, provide pertinent records, and take all other actions, including requiring persons within its control to give testimony, which may be reasonably
required in connection with the defense or settlement of such litigation. 

7.     TREATMENT OF CONFIDENTIAL INFORMATION; PUBLICITY  

        7.1    Confidentiality.    Subject to the terms and conditions of this Agreement, Senomyx and Aurora each agree that,
during the Term and for a period of [***] thereafter, it will keep confidential, and will cause its Affiliates to keep
confidential, all Confidential Information that is disclosed to it or to any of 

13

 

its
Affiliates by the other party. Neither Senomyx nor Aurora nor any of their respective Affiliates shall use the other party's Confidential Information, except as expressly permitted in this
Agreement. 

        7.1.1    Disclosure to Related Parties.    Senomyx and Aurora each
agree that any disclosure of the other party's Confidential Information to any officer, employee, contractor, consultant, sublicensee or agent of the other party or to any of its Affiliates shall be
made only if and to the extent necessary to carry out its responsibilities under this Agreement and to exercise the rights granted to it hereunder, shall be limited to the extent consistent with such
responsibilities and rights, and shall be provided only to such persons or entities who are under an obligation of confidentiality no less stringent than as set forth herein. Each party shall use
reasonable efforts to take such action, and to cause its Affiliates to take such action, to preserve the confidentiality of each other's Confidential Information, which shall be the same efforts as it
would customarily take to preserve the confidentiality of its own Confidential Information. Each party shall promptly notify the other party upon discovery of any unauthorized use or disclosure of the
other party's Confidential Information. 

        7.1.2    Return of Confidential Material Upon Termination.    Upon
termination of this Agreement, each party, upon the other party's request, will return or destroy all Confidential Information received from the other party pursuant to this Agreement, including all
copies and extracts of documents, within thirty (30) days of the request of the other party; provided, however, one copy of such Confidential
Information may be retained for legal purposes. 

        7.1.3    Exceptions to Confidential Information.    Confidential
Information shall not include any information, which the receiving party can prove by competent written evidence: 

           i)  is
now, or hereafter becomes, through no act or failure to act on the part of the receiving party, generally known or available; 

          ii)  is
known by the receiving party at the time of receiving such information, as evidenced by its records; 

         iii)  is
hereafter furnished to the receiving party without restriction as to disclosure or use by a Third Party lawfully entitled to furnish such information; 

          iv)  is
independently developed by the employees, agents or contractors of the receiving party without the aid, application or use of the disclosing party's Confidential
Information; 

          vi)  is
the subject of a written permission to disclose provided by the disclosing party; or 

        vii)  is
provided by the disclosing party to a Third Party without restriction as to confidentiality. 

        A
party may also disclose Confidential Information of the other party where required to do so by law or legal process; provided, however,
that, in such event, the party required to disclose such information shall give advance written notice of such disclosure to the other party and will cooperate with the other party's efforts to seek,
at the request and expense of the other party, all confidential treatment and protection for such disclosure as is permitted by applicable law. 

        7.1.4    Confidential Financial Information.    The parties agree that
the material financial terms of this Agreement will be considered Confidential Information of both parties. Notwithstanding the foregoing, either party may disclose such terms in legal proceedings or
as are required to be disclosed in its financial statements, by law, or under an obligation of confidentiality to bona fide potential sublicensees. Either party shall have the further right to
disclose the material financial terms of this Agreement under an obligation of confidentiality to any potential acquirer, merger partner, bank, venture capital firm, or other financial institution to
obtain financing. Notwithstanding the foregoing, the parties shall agree upon a press release to announce the 

14

 

execution
of this Agreement. Thereafter, Aurora and Senomyx may each disclose to Third Parties the information contained in such press release without the need for further approval by the other party. 

        7.1.5    Confidential Research Information.    The parties agree that
information developed using an Assay Platform will be considered Confidential Information of both parties and shall be subject to the confidentiality requirements of this Article 7.
Notwithstanding the foregoing, either party may disclose and use information developed using an Assay Platform that is not specific to a Target proposed by Senomyx for screen development and screening
under an obligation of confidentiality to bona fide sublicensees. 

        7.2    Permitted Use and Disclosures.    Each party may use or disclose Confidential Information disclosed to it by
the other party to the extent such information is included in the Aurora Technology, Senomyx Technology or Joint Patent Rights, and to the extent such use or disclosure is reasonably necessary and
permitted in the exercise of the rights granted hereunder in filing or prosecuting patent applications, prosecuting or defending litigation, complying with applicable governmental regulations or court
orders
or otherwise submitting information to tax or other governmental authorities, conducting clinical trials, or making a permitted sublicense or otherwise exercising rights expressly granted to the other
party pursuant to the terms of this Agreement; provided, however, that if a party is required to make any such disclosure of the other party's
Confidential Information, other than pursuant to a confidentiality agreement, it will give reasonable advance notice of such disclosure to the other party where reasonably possible and, save to the
extent inappropriate in the case of patent applications, will use its reasonable efforts to secure confidential treatment of such Confidential Information in consultation with the other party prior to
such disclosure (whether through protective orders or otherwise) and disclose only the minimum necessary to comply with such requirements. 

        7.3    Use of Data for Promotional Purposes.    Either party may (i) make public statements regarding Products
by announcing the achievement of milestones and fees therefor, following consultation with the other party and with the written consent of the other party to the form and content of the public
statement, and (ii) without the prior consent of the other party, make public statements regarding the overall success rate(s) achieved by and/or for its customers with the use of Aurora
Technology or Senomyx Technology; provided, however, that it may not disclose any chemical structures, screens or the other party's identity. 

        7.4    Publication of Results.    Subject to this Article 7, results and data obtained by either party in the
course of the collaboration, including, but not limited to, the execution of a Work Plan or an Aurora Screening Program pursuant to this Agreement, may be submitted for publication by Senomyx in
accordance with Senomyx's customary practices; provided, however, that Senomyx shall credit Aurora in such publication as the developer and/or provider
of the technology that produced, in part, the published results or data. Senomyx shall send a copy of the proposed publication to Aurora at least forty-five (45) days prior to
submitting the paper to a publisher and shall allow Aurora thirty (30) days from the date of receipt in which to determine whether such publication contains subject matter for which patent
protection should be sought prior to disclosure, or otherwise contains Aurora Confidential Information. Senomyx shall comply with Aurora's request to delete references to Aurora's Confidential
Information in any such paper and agrees to withhold publication of the same for an additional one hundred and eighty (180) days to permit Aurora to obtain patent protection, if Aurora deems it
necessary, in accordance with the terms of this Agreement. If no answer is received from Aurora within thirty (30) days of receipt of the proposed publication, Senomyx shall be free to submit
such proposed publication. 

        7.5    Publicity.    Except as required by law and as provided in this Article 7, neither party may make any
public announcement or otherwise disclose the terms of this Agreement without the prior written consent of the other party, which consent shall not be unreasonably withheld. 

15

   8.     PATENT PROSECUTION AND MAINTENANCE  

        The control and expense of the filing, prosecution (including an opposition or interference) and maintenance of Patent Rights or other intellectual property
rights claiming Inventions made solely by a party will be the sole responsibility of the party that made such Invention, and the party not filing the patent application will cooperate in such filing,
prosecution and maintenance. Senomyx and Aurora will determine by mutual agreement which party will be responsible for, and will cooperate in, the filing, prosecution and maintenance of Joint Patent
Rights and will share equally in the expenses incurred with respect thereto. 

9.     WARRANTIES AND INDEMNIFICATION  

        9.1    Mutual Representations and Warranties.    Each party hereby makes the following representations and warranties
to the other party: 

        9.1.1    Corporate Power.    Each party hereby represents and warrants
that such party (a) is duly organized and validly existing under the laws of the state of its incorporation and has full corporate power and authority to enter into this Agreement and to carry
out the provisions hereof; (b) has the requisite power and authority and the legal right to own and operate its property and assets, to lease the property and assets it operates under lease,
and to carry on its business as it is now being conducted; and (c) is in compliance with all requirements of applicable law, except to the extent that any noncompliance would not have a
material adverse effect on its ability to perform its obligations under the Agreement. 

        9.1.2    Due Authorization.    Each party hereby represents and
warrants that such party (a) has the requisite power and authority and the legal right to enter into the Agreement and to perform its obligations hereunder; and (b) has taken all
necessary action on its part to authorize the execution and delivery of the Agreement and to authorize the performance of its obligations hereunder and the grant of rights extended by it hereunder. 

        9.1.3    Binding Agreement.    Each party hereby represents and
warrants to the other that (a) this Agreement has been duly executed and delivered on its behalf and is a legal and valid obligation binding upon it and is enforceable in accordance with its
terms; (b) the execution, delivery and performance of this Agreement by such party does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or
by which it may be bound, nor violate any law or regulation of any court, governmental body or administrative or other agency having authority over it; and (c) all necessary consents, approvals
and authorizations of all governmental authorities and other persons required to be obtained by it in connection with the Agreement have been obtained. 

        9.2    Warranties Regarding Senomyx Technology.    Senomyx represents and warrants to Aurora as of the Effective Date
the following: 

        9.2.1    To the best knowledge of Senomyx as of the Effective Date: (a) Senomyx has the lawful right to license the
Senomyx Technology to Aurora in accordance with the terms of this Agreement; (b) the Senomyx Patent Rights were properly filed and prosecuted; and (c) no Third Party suit exists relating
to the Senomyx Patent Rights. 

        9.2.2    EXCEPT AS EXPRESSLY SET FORTH HEREIN, SENOMYX (INCLUDING ITS OFFICERS, EMPLOYEES AND AGENTS) EXPRESSLY DISCLAIMS ANY
REPRESENTATIONS AND WARRANTIES, WHETHER EXPRESS OR IMPLIED, RELATING TO SENOMYX TECHNOLOGY. SENOMYX FURTHER DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY (a) OF MERCHANTABILITY OR FITNESS FOR A
PARTICULAR PURPOSE OF SENOMYX TECHNOLOGY; (b) THAT THE PRACTICE OF SENOMYX TECHNOLOGY WILL NOT INFRINGE A PATENT, COPYRIGHT, 

16

 

TRADEMARK
OR OTHER RIGHT OF A THIRD PARTY; AND (c) REGARDING THE PATENTABILITY OF ANY SENOMYX TECHNOLOGY, INCLUDING SENOMYX TECHNOLOGY CLAIMED IN PATENT APPLICATIONS AS PART OF SENOMYX PATENT
RIGHTS. 

        9.3    Senomyx Indemnification.    

        9.3.1    Senomyx hereby agrees to indemnify, defend and hold Aurora, and its respective officers, directors, employees and
agents (collectively, the "Aurora Indemnitees") harmless from and against all damages, losses, liabilities, expenses and costs or other amounts payable to a Third Party, including reasonable
attorneys' fees and costs of litigation, resulting from a claim, demand, action, suit or other proceeding brought or threatened by a Third Party against an Aurora Indemnitee based on (a) any
development, manufacture, use, handling, storage, sale or other disposition of a Development Compound or Product by or through Senomyx or its Affiliates, Licensees or permitted sublicensees,
(b) the practice by
Senomyx of any license granted hereunder, or (c) infringement by Aurora of Patent Rights of any Third Party as a result of using a Target in an Assay Platform, or Compound Supply provided under
this Agreement by Senomyx; except to the extent such damages or other amounts payable are attributable to: (i) a violation of any contractual or fiduciary duty owed by any Aurora Indemnitee to
a Third Party, (ii) any material breach of this Agreement by an Aurora Indemnitee, or (iii) trade secret misappropriation or patent infringement by Aurora of screen components (other
than a Target or Compound Supply) that are Controlled by a Third Party or are covered by a Third Party's Patent Rights. IN NO EVENT SHALL SENOMYX BE LIABLE FOR ANY INCIDENTAL OR CONSEQUENTIAL DAMAGES
SUFFERED BY AURORA RESULTING FROM THE EXERCISE OF ANY RIGHTS GRANTED IN ACCORDANCE WITH THIS AGREEMENT. 

        9.3.2    With respect to rights licensed to Aurora by  [***] Senomyx hereby agrees to indemnify,
defend and hold harmless  [***], as appropriate, and their respective officers, directors, employees, sponsors and agents from and against all damages or
other amounts payable to a Third Party (including product liability) resulting or arising from Senomyx's use of the rights granted herein to the extent that such indemnification by Senomyx is required
by [*** ] pursuant to agreements between [***]. 

        9.4    Warranties Relating to Aurora Technology.    Aurora represents and warrants to Senomyx as of the Effective Date
the following: 

        9.4.1    To the best knowledge of Aurora as of the Effective Date: (a) Aurora has the lawful right to license (or
sublicense, as the case may be) the Aurora Technology to Senomyx in accordance with the terms of this Agreement; (b) the Aurora Patent Rights were properly filed and prosecuted; and
(c) no Third Party suit against Aurora exists relating to the Aurora Patent Rights. 

        9.4.2    EXCEPT AS EXPRESSLY SET FORTH HEREIN, AURORA (INCLUDING ITS OFFICERS, EMPLOYEES AND AGENTS) EXPRESSLY DISCLAIMS ANY
REPRESENTATIONS AND WARRANTIES OF ANY KIND, WHETHER EXPRESS OR IMPLIED, RELATING TO AURORA TECHNOLOGY OR AURORA REPORTERS. AURORA FURTHER DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY (a) OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF AURORA TECHNOLOGY OR AURORA REPORTERS; (b) THAT THE PRACTICE OF AURORA TECHNOLOGY OR AURORA REPORTERS WILL NOT INFRINGE A PATENT,
COPYRIGHT, TRADEMARK, TRADE SECRET OR OTHER RIGHT OF A THIRD PARTY; AND (c) REGARDING THE PATENTABILITY OF ANY AURORA TECHNOLOGY OR AURORA REPORTERS, INCLUDING AURORA TECHNOLOGY OR AURORA 

17

 

REPORTERS
CLAIMED IN PATENT APPLICATIONS AS PART OF AURORA PATENT RIGHTS. 

        9.5    Aurora Indemnification.    

        9.5.1    Aurora hereby agrees to indemnify, defend and hold Senomyx and its respective officers, directors, employees and agents
(collectively the "Senomyx Indemnitees") harmless from and against all damages, losses, liabilities, expenses and costs or other amounts payable to a Third Party, including reasonable attorneys' fees
and costs of litigation, resulting from a claim, demand, action, suit, or other proceeding brought or threatened by a Third Party against a Senomyx Indemnitee based on Aurora's gross negligence,
intentional misconduct, trade secret misappropriation or material misrepresentations contained herein. IN NO EVENT SHALL AURORA BE LIABLE FOR ANY INDIRECT, INCIDENTAL,SPECIAL OR CONSEQUENTIAL DAMAGES
SUFFERED BY SENOMYX RESULTING FROM THE EXERCISE OF ANY RIGHTS GRANTED IN ACCORDANCE WITH THIS AGREEMENT. 

        9.5.2    Aurora hereby agrees to indemnify, defend and hold  [***] and its respective officers, sponsors, directors, employees and agents
(collectively the "IP Indemnitees") harmless from
and against all damages or other amounts payable to a Third Party, including reasonable attorneys' fees and costs of litigation, resulting or arising from the exercise of rights under the license
granted from Senomyx to Aurora under Section 4.2 and pursuant to any agreement between [***] and Senomyx, including
product liability. 

10.   TERM AND TERMINATION  

        10.1    Term.    The term of this Agreement will begin on the Effective Date and shall continue until there is no
longer a royalty obligation owed by Senomyx to Aurora under this Agreement, unless terminated earlier in accordance with the provisions of Section 10.2, 10.3 or 10.4 hereof (the "Term"). 

        10.2    Termination by Senomyx.    Senomyx may terminate this Agreement without cause at any time upon  [***] prior written notice to Aurora which notice may not be provided earlier than [***
] from the Effective Date. 

        10.3    Termination By Mutual Agreement.    Notwithstanding Section 10.2, the parties may terminate this
Agreement at any time, in whole or in part, by mutual written agreement executed by both Aurora and Senomyx. 

        10.4    Termination for Breach.    Aurora shall have the right to terminate this Agreement at any time if Senomyx
fails to make any payment when due under this Agreement, provided that Senomyx has not
made such payment within [***] after written notice thereof by Aurora. Either party shall have the right to terminate this
Agreement at any time for a material breach of this Agreement (other than non-payment) by the other party, provided that the breaching party has not cured such breach within  [***] after written notice
thereof by the non-breaching party. The non-breaching party, upon termination
of this Agreement, may seek actual or general damages and remedies available to it at law or in equity. NO PUNITIVE OR CONSEQUENTIAL DAMAGES MAY BE SOUGHT BY EITHER PARTY. 

        10.5    Effect of Termination.    

        10.5.1    Upon termination of this Agreement pursuant to Section 10.2, (i) Senomyx shall have no right to practice
within the Aurora Patent Rights or use any of the Aurora Technology or any Aurora Reporter, unless Senomyx pays to Aurora an early termination fee of  [***] within [***]
, and (ii) Senomyx shall pay
Aurora additional research support in accordance with Section 3.1 for a period of [***] following the date Senomyx
notifies Aurora of such termination. 

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        10.5.2    Upon termination of this Agreement pursuant to Section 10.3, (i) Senomyx shall have no right to practice
within the Aurora Patent Rights or use any of the Aurora Technology or any Aurora Reporter, and (ii) all rights, title or interest in, or other incidents of ownership under, the Aurora
Technology and Aurora Reporters shall revert to and become the sole property of Aurora, unless otherwise agreed upon in writing by the parties on or before the effective date of such termination. 

        10.5.3    Upon termination of this Agreement pursuant to Section 10.4, (i) Senomyx shall have no right to practice
within the Aurora Patent Rights or use any of the Aurora Technology or any Aurora Reporter, and (ii) all rights, title or interest in, or other incidents of ownership under, the Aurora
Technology and Aurora Reporters shall revert to or become the property of Aurora. 

        10.5.4    Expiration or termination of this Agreement shall not relieve either party of any obligation accruing prior to such
expiration or termination. 

        10.6    Survival.    The obligations and rights of the parties under Sections 2.4.5, 4.3, 5.4, 10.5 and 10.6 and
Articles 1, 7, 9 and 11 shall survive termination or expiration of this Agreement. 

11.   MISCELLANEOUS  

        11.1    Assignment.    Notwithstanding any provision of this Agreement to the contrary, neither party may assign any
of its rights or obligations under this Agreement in any country to any Third Party without the prior written consent of the non-assigning party, which consent shall not be unreasonably
withheld; provided, however, that either party may assign its rights and obligations under this Agreement without the consent of the other party
(i) in connection with the transfer or sale of all or substantially all of its assets, or (ii) to any Affiliate. In the event of such transaction, however, intellectual property rights
(including Know-How) of a party to such transaction other than one of the parties to this Agreement, shall not be included in the technology licensed hereunder. Notwithstanding the
foregoing, any such assignment to an Affiliate shall not relieve the assigning party of its responsibilities for performance of its obligations under this Agreement. This Agreement shall survive any
merger or consolidation of either party with or into another party and no consent for any such merger, consolidation or similar reorganization shall be required hereunder. 

        11.2    Binding Effect.    This Agreement shall be binding upon and inure to the benefit of the successors and
permitted assigns of the parties. Any assignment not in accordance with this Agreement shall be void. 

        11.3    Force Majeure.    Neither party shall lose any rights hereunder or be liable to the other party for damages or
losses on account of failure of performance by the defaulting party if the failure is occasioned by war, fire, explosion, flood, El Niño, earthquake, strike, lockout, embargo, act of
God, or any other similar cause beyond the control of the defaulting party; provided, however, that the party claiming force majeure has exerted all
reasonable efforts to avoid or remedy such force majeure and thereafter takes all reasonable steps to mitigate any such delay in performance hereunder and any damages that may be incurred by the other
party thereby. 

        11.4    Notices.    Any notices or communications provided for in this Agreement to be made by either party to the
other party shall be in writing, in English, and shall be made by prepaid air mail or overnight carrier with return receipt addressed to the other party at its address set forth below. Any 

19

 

such
notice or communication may also be given by hand or facsimile to the appropriate designation. Notices shall be sent: 

If
to Senomyx, to: 

Senomyx, Inc.

11099 North Torrey Pines Road

La Jolla, CA 92037

Facsimile number: (858) 404-0750

Attention: Vice President, Corporate Counsel

with a copy to the President 

If
to Aurora, to: 

Aurora
Biosciences Corporation

11010 Torreyana Road

San Diego, CA 92121

Facsimile number: (858) 404-6743

Attention: General Counsel

with a copy to the President 

        Either
party may by like notice specify or change an address to which notices and communications shall thereafter be sent. Notices sent by mail, facsimile or overnight carrier shall be
effective upon receipt and notices given by hand shall be effective when delivered. 

        11.5    Governing Law and Jurisdiction.    This Agreement shall be governed by the laws of the State of California, as
such laws are applied to contracts entered into and to be performed entirely within such state. 

        11.6    Waiver.    Except as specifically provided for herein, the waiver from time to time by either party of any
right or the failure to exercise any remedy shall not operate or be construed as a continuing waiver of the same right or remedy or any of the other of such party's rights or remedies provided in this
Agreement. 

        11.7    Severability.    If any term, covenant or condition of this Agreement or the application thereof to any party
or circumstance shall, to any extent, be held to be invalid or unenforceable, then the remainder of this Agreement, or the application of such term, covenant or condition to parties or circumstances
other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each term, covenant or condition of this Agreement shall be valid and enforced to the fullest extent
permitted by law. The parties covenant and agree to renegotiate any such term, covenant or condition or the application thereof in good faith in order to provide a reasonably acceptable alternative to
the term, covenant or condition of this Agreement or the application thereof that is invalid or
unenforceable, it being the intent of the parties that the basic purposes of this Agreement are to be effectuated. 

        11.8    Independent Contractors.    It is expressly agreed that Aurora and Senomyx shall be independent contractors
and that the relationship between the parties shall not constitute a partnership or agency of any kind. Neither Aurora nor Senomyx shall have the authority to make any statements, representations or
commitments of any kind, or to take any action, which shall be binding on the other party, without the prior written authorization of the other party to do so. 

        11.9    Counterparts.    This Agreement may be executed in two (2) or more counterparts, each of which shall be
deemed an original, but all of which together shall constitute one and the same instrument. 

20

 

        11.10    Entire Agreement; Amendment.    This Agreement sets forth all of the covenants, promises, agreements,
warranties, representations, conditions and understandings between the parties, and supersedes and terminates all prior agreements and understandings between the parties, with respect to the subject
matter hereof. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the parties other than as set forth herein. No
subsequent alteration, amendment, change or addition to this Agreement shall be binding upon the parties unless reduced to writing and signed by the respective authorized officers of the parties. This
Agreement shall not be strictly construed against either party. Any conflict between the terms set forth in the text of this Agreement and the terms of any Exhibit hereto shall be resolved in favor of
the text of this Agreement. 

        11.11    No Third Party Beneficiaries.    No Third Party, including any employee of any party to this Agreement
(except as specifically provided in Sections 9.3 and 9.5), shall have or acquire any rights by reason of this Agreement. Nothing contained in this Agreement shall be deemed to constitute the parties
partners with each other or any Third Party. 

        11.12    Construction.    The term "Article" or "Section" can refer to any single paragraph level found herein or any
collection of multiple paragraphs thereunder. 

        11.13    Dispute Resolution.    The parties recognize that disputes as to certain matters may from time to time arise
during the Term, which relate to either party's rights and/or obligations hereunder. It is the objective of the parties to establish procedures to facilitate the resolution of disputes arising under
this Agreement in an expedient manner by mutual cooperation and without resort to arbitration. The parties agree that prior to any arbitration concerning this Agreement, Senomyx's  [*** ] and Aurora's
[***] will meet in person or by
video-conferencing in a good faith effort to resolve any disputes concerning this Agreement. Within thirty (30) days of a formal request by either party to the other party, either party may, by
written notice to the other party, have such dispute referred to their respective officers designated or their successors, for attempted resolution by good faith negotiations, such good faith
negotiations to begin within thirty (30) days after such notice is received. Any dispute arising out of or relating to this Agreement which is not resolved between the parties or the designated
officers of the parties pursuant to this Section 11.13 shall be resolved by final and binding arbitration conducted in San Diego, California (unless the parties mutually agree to another
location) in accordance with Sections 1282 through 1288 of the California Code of Civil Procedure. The arbitration shall be conducted by three (3) arbitrators who are knowledgeable in the
subject matter which is at issue in the dispute. One (1) arbitrator will be selected by Senomyx and one (1) arbitrator will be selected by Aurora. The third arbitrator will be selected
by mutual agreement of the two (2) arbitrators selected by the parties. In conducting the arbitration, the arbitrators shall (i) determine what discovery will be permitted, consistent
with the goal of limiting the cost and time which the parties must expend for discovery (and provided that the arbitrators shall permit such discovery they deem necessary to permit an equitable
resolution of the dispute), (ii) ensure that the total time of the arbitration from filing to a final decision or executed settlement agreement is less than six (6) months, and
(iii) be able to decree any and all relief of an equitable nature, including, but not limited to, such relief as a temporary restraining order, a preliminary injunction, a permanent injunction,
specific performance or repletion of property. The arbitrators shall also be able to award actual or general damages, but shall not award any other form of damage (e.g., consequential, punitive or
exemplary damages). The parties shall share equally the arbitrator's fees and expenses pending the resolution of the arbitration, unless the arbitrators, pursuant to their right, but not their
obligations, require the non-prevailing party to bear all or any portion of the costs of the prevailing party. The decision of the arbitrators shall be final and binding on the parties and
may be sued on or enforced by the party in whose favor it runs in any court of competent jurisdiction at the option of such party. Notwithstanding anything to the contrary in this
Section 11.13, either party may seek immediate injunctive or other interim relief from any court of competent jurisdiction with respect to any breach of Articles 4 or 7 hereof, or otherwise to
enforce and 

21

 

protect
the Patent Rights, copyrights, trademarks, or other intellectual property rights Controlled by such party. In addition, arbitration shall not be used to resolve disputes concerning Patent
Rights. Disputes concerning Patent Rights, including, but not limited to, disputes concerning patent ownership, claim language, claim scope and issues of validity shall be settled in a court of law.
Any arbitration ruling that relies on an interpretation of Patent Rights shall have no binding effect in a court of law on any Patent Rights related to this Agreement, unless such Patent Rights have
been adjudicated in a court of law. In no event shall a demand for arbitration be made after the date when the institution of a legal or equitable proceeding based on such claim, dispute or other
matter in question would be barred by the applicable statute of limitations. 

22

   
        IN WITNESS WHEREOF, the parties have caused this Agreement to be executed by their duly authorized representatives as of the Effective Date. 

	SENOMYX, INC.	 	AURORA BIOSCIENCES CORPORATION
	

By:	
 	

/s/  PAUL A. GRAYSON      
	
 	

By:	
 	

/s/  STUART J. M. COLLINSON      

	Name:	 	Paul A. Grayson	 	Name:	 	Stuart J. M. Collinson
	Title:	 	President and CEO	 	Title:	 	Chairman, CEO and President
	

Date:	
 	

November 1, 2000
	
 	

Date:	
 	

November 1, 2000

23

 
LIST OF EXHIBITS  

	Exhibit 1:	 	List of Aurora Patent Rights
	
Exhibit 2:	
 	

List of Senomyx Patent Rights
	
Exhibit 3:	
 	

Description of Reporters
	
Exhibit 4:	
 	

Stock Purchase Agreement
	
Exhibit 5:	
 	

Senomyx Target List
	
Exhibit 6:	
 	

Assay Platform Validation Criteria
	
Exhibit 7:	
 	

VIPR and VIPR II Performance Criteria and Service and Support

24

 
EXHIBIT 1  

[***]

[***]

25

 

[***]

26

 

[***]

27

 
EXHIBIT 2  

        [***]

28

 

[***]

29

 
EXHIBIT 3  

        [***]

30

 
EXHIBIT 5  

 Senomyx Target List  

        Sequences listed as an attachment to this Exhibit, and incorporated by reference, include the following molecules: 

        [***]

31

 
EXHIBIT 6  

        [***]

32

 
EXHIBIT 7  

 Performance Specifications  

        [***]

33

  

CONFIDENTIAL

***Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

Under 17 C.F.R. Sections 200.80(b)(4),

200.83 and 230.406.  

 
 

FIRST AMENDMENT
  TO THE
  COLLABORATIVE RESEARCH AND LICENSE AGREEMENT    
    

        THIS FIRST AMENDMENT TO THE COLLABORATIVE RESEARCH AND LICENSE AGREEMENT (the "First Amendment") is made by and between SENOMYX, INC. ("Senomyx"), a
Delaware corporation, having a principal place of business at 11099 North Torrey Pines Road, La Jolla, California 92037, and AURORA BIOSCIENCES CORPORATION ("Aurora"), a Delaware corporation, having a
principal place of business at 11010 Torreyana Road, San Diego, California 92121. 

        WHEREAS,
Senomyx and Aurora entered into that certain Collaborative Research and License Agreement dated as of November 1, 2000 (the "Agreement") to collaborate in the development
of assays and screening systems to identify and develop small molecules for use in consumer products and therapeutics (capitalized terms used but not otherwise defined in this First Amendment shall
have the meanings given such terms in the Agreement); and 

        WHEREAS,
Senomyx and Aurora wish to amend the Agreement in the manner set forth in this First Amendment and otherwise to provide for certain agreements by the parties as set forth
herein. 

        NOW,
THEREFORE, in consideration of the foregoing premises and of the covenants, representations and agreements set forth below, the parties hereby agree to amend the Agreement as
follows: 

	1.
	The
definitions of "Collaborative Period", "Field II" and "Target" in Article 1 of the Agreement are hereby amended and restated its entirety as follows:

	

	"Collaborative
Period" means the period beginning on the Effective Date and ending on October 31, 2002, unless terminated earlier in accordance with
Section 10.3 or 10.4.

	

	"Field
II" means [***].

	

	"Target"
means a target identified in taste, olfaction or pheromone detection.

	2.
	The
definition of "Therapeutic Target" is hereby added to Article 1 of the Agreement as follows:

	

	"Therapeutic
Target" means a Target listed on Exhibit 5, as modified from time to time by the Steering Committee as provided under
Section 2.2.

	3.
	The
first sentence in Section 3.1 of the Agreement is hereby amended and restated in its entirety as follows:

	

	"During
the first fifteen (15) months of the Collaborative Period, Senomyx will pay Aurora for  [***] FTEs at an annual rate of [***] per FTE. During
the remaining nine (9) months of the Collaborative Period, Senomyx will pay Aurora for [***] FTEs at an annual rate of  [***] per FTE."

	4.
	Section 3.2
of the Agreement is hereby deleted in its entirety. The numbering of all other sections within Article 3 will remain unchanged. 

1

 
	5.
	The
last sentence in Section 3.8 of the Agreement is hereby amended and restated in its entirety as follows:

	

	"Senomyx
may, in its sole discretion, extend the warranty on the VIPR or the VIPR II beyond such  [***] period for [***] per year payable on  [***] thereafter; provided, however, such right to extend the warranty shall
expire on the [***] of the Effective Date."

	6.
	Section 4.1.1
of the Agreement is hereby amended and restated in its entirety as follows:

	

	"4.1.1    Non-Exclusive License to use Aurora Technology in Assay
Platforms.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Assay Platforms solely to conduct Internal Research:

	(a)
	to
develop screens for the Therapeutic Targets and to screen the Therapeutic Targets (i) to identify, discover and profile compounds in Field I, and (ii) to make, have
made, use, sell, offer for sale and import compounds or Products in Field I identified or discovered with activity against such Therapeutic Targets in the Assay Platforms; and

	(b)
	to
develop screens for the Targets and to screen the Targets (i) to identify, discover and profile compounds in Field II, and (ii) to make, have made, use, sell, offer
for sale and import compounds or Products in Field II identified or discovered with activity against such Targets in the Assay Platforms."

	7.
	Section 4.1.3
of the Agreement is hereby amended and restated in its entirety as follows:

	

	"4.1.3    Non-Exclusive License to use Aurora Reporters for Internal Research of Therapeutic
Targets.    Subject to the terms and conditions of this Agreement, Aurora hereby grants to Senomyx a non-transferable, except as provided in
Section 11.1, non-exclusive, worldwide license, without the right to grant sublicenses, under the Aurora Technology to use the Aurora Reporters solely to conduct Internal Research
on the Therapeutic Targets (i) to identify, discover and profile compounds in Field I, and (ii) to make, have made, use, sell, offer for sale and import compounds or Products in Field I
identified or discovered with activity against such Therapeutic Targets."

	8.
	Section 10.1
of the Agreement is hereby amended and restated in its entirety as follows:

	

	"10.1    Term.    The term of this Agreement will begin on the Effective Date and will
continue until October 31, 2002, unless terminated earlier in accordance with the provisions of Section 10.3 or 10.4 hereof (the "Term")."

	9.
	Section 10.2
is hereby deleted in its entirety. The numbering of all other sections within Article 10 will remain unchanged.

	10.
	Section 10.5.1
of the Agreement is hereby amended and restated in its entirety as follows:

	

	"10.5.1    Senomyx
will pay to Aurora a non-creditable, non-refundable termination fee of  [***] on or before October 30, 2002."

	11.
	Section 10.6
of the Agreement is hereby amended and restated in its entirety as follows:

	

	"10.6    Survival.    The obligations and rights of the parties under Sections 2.4.5,
2.5, 3.4, 3.8, 4.1.7, 4.3, 10.4, 10.5 and 10.6 and Articles 1, 5, 7, 9 and 11 will survive the termination or expiration of this Agreement. In addition, upon the expiration of this Agreement in
accordance with Section 10.1, the rights granted to Senomyx under Section 4.1 shall remain in full force and effect as long as Senomyx is not in material breach of its obligations to
Aurora under this Agreement."

	12.
	In
consideration for the [***] assay that Aurora has delivered to Senomyx, Senomyx will pay to Aurora a
non-creditable, non-refundable milestone payment of [***] on or before April 30, 2002. 

2

 
	13.
	Senomyx
will pay to Aurora the annual research support payment due February 1, 2002 under Section 3.1 on or before April 30, 2002.

	14.
	Except
as specifically amended by this First Amendment, the terms and conditions of the Agreement shall remain in full force and effect.

	15.
	This
First Amendment shall be governed by the laws of the State of California, as such laws are applied to contracts entered into and to be performed entirely within such state.

	16.
	This
First Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties have executed this First Amendment effective as of April 16, 2002. 

	SENOMYX, INC.	 	AURORA BIOSCIENCES CORPORATION
	 	 	 
	 	 	 
	/s/  PAUL A. GRAYSON      
 Paul A. Grayson

Chairman and CEO	 	/s/  HARRY STYLLI      
 Harry Stylli

President

3

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COLLABORATIVE RESEARCH AND LICENSE AGREEMENT BETWEEN SENOMYX, INC. AND AURORA BIOSCIENCES CORPORATION

FIRST AMENDMENT TO THE COLLABORATIVE RESEARCH AND LICENSE AGREEMENTQuickLinks
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Exhibit 10.13  

***Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

Under 17 C.F.R. Sections 200.80(b)(4),

200.83 and 230.406.  

 
 

COLLABORATIVE RESEARCH
  AND LICENSE AGREEMENT    
    
    BETWEEN    
    
    SENOMYX, INC.    
    
    AND    
    
    KRAFT FOODS, INC.    
    

1

 
COLLABORATIVE RESEARCH AND LICENSE AGREEMENT  

        THIS AGREEMENT is entered into as of the Effective Date by and between SENOMYX, INC., a Delaware Corporation having offices at 11099 North Torrey Pines
Road, La Jolla, CA 92037 ("Senomyx") and KRAFT FOODS, INC., a Delaware Corporation having offices at 801 Waukegan Road, Glenview, IL 60025 ("Kraft"). 

BACKGROUND  

        Senomyx conducts research in the field of chemosensation, an objective of which is to study potential biological targets and develop assays for use in the
discovery and commercialization of products in taste and olfaction. Kraft is in the business of developing, manufacturing and marketing consumer food products. Senomyx and Kraft desire to collaborate
in a research program to: (i) discover compounds that [***] for use in  [***]; and (ii) discover compounds that [***]
 for
use in [***] products. 

        NOW,
THEREFORE, in consideration of the foregoing premises and of the covenants, representations and agreements set forth below, the parties hereby agree as follows: 

THE AGREEMENT  

1.    Definitions.    Certain terms set forth in this Agreement with initial
capitals are defined in Appendix A, which is incorporated herein by reference. 

2.    Steering Committee.    No later than ten days after the Effective Date, the
parties will establish a joint steering committee (the "Steering Committee"). The Steering Committee will manage the Collaborative Program and will (i) provide strategic direction and
performance criteria for the Collaborative Program; (ii) monitor progress and communicate status of the Collaborative Program; (iii) facilitate the cooperation of the parties under the
Collaborative Program; and (iv) confirm completion of milestones under the Collaborative Program. The Steering Committee will consist of two representatives designated by Senomyx and two
representatives designated by Kraft. Each member of the Steering Committee will have one vote. The Steering Committee will meet no later than thirty days after the Effective Date and at least four
times per year during the Collaborative Period using mutually agreed upon meeting locations and formats including tele-conferencing and video-conferencing. On an alternating basis, one
party will promptly prepare and deliver to the members of the Steering Committee minutes of such meetings for review and approval of both parties. Decisions in the Steering Committee will be made by
unanimous vote, at a meeting where all four voting representatives are present. All unresolved disputes will be settled in accordance with Section 18.4, or as otherwise mutually agreed upon in
writing. 

3.    Collaborative Program.    The parties will collaborate in the conduct of the
Collaborative Program in accordance with the Research Plan during the Collaborative Period. The Collaborative Program will consist of two phases: the  [***] Phase and the [***]
 Phase, which may overlap. 

        3.1    [***] Phase.    

        (A)  Within
[***] of the Effective Date, Kraft will, at its expense, supply Senomyx with  [***] Tastants for screening in accordance with the Research Plan. During the
 [***] Phase, Kraft may provide additional purified [***]
Tastants for profiling as agreed to in writing by the parties and approved by the Steering Committee. 

        (B)  Upon
receipt of the [***] Tastants, Senomyx will perform the activities outlined in the Research
Plan using reasonable efforts, and the resources provided under Section 9.1. 

2

 

        (C)  Within
[***] of receipt of the report regarding the  [***] Compounds, Kraft will perform sensory testing and other evaluations on a limited number of the 
[***] Compounds and may select [***] Compound(s) for
further development by notifying Senomyx of such selection in writing by the end of such [***] period. Such  [***] period may be extended by agreement; such
agreement will not be
unreasonably withheld. [***] Compounds, if any, chosen for further development become Selected  [***] Compounds. 

        (D)  Senomyx's
obligations during the [***] Phase will be completed upon the earlier of
(i) Senomyx's submission of a written report to Kraft regarding [***] Compounds; or (ii) upon Senomyx's submission
of a written report to Kraft regarding [***] Compounds, provided that the Steering Committee determines that the identification
of [***] Compounds is reasonable. [***] If necessary,
Senomyx may provide additional optimization as agreed to in writing by the parties and approved by the Steering Committee. 

        3.2    [***] Phase.    

        (A)  Kraft
may request that Senomyx pursue the identification of [***] Compounds upon the earlier of
(i) the completion of the [***] Phase; or (ii) Kraft's request to begin the  [***] Phase prior to the completion of the [***] Phase,
provided that Kraft agrees to provide research support funding for the [***] Phase in addition to the  [***] Phase in an amount agreed upon in writing by
the parties and approved by the Steering Committee. 

        (B)  Upon
initiation of the [***] Phase, Kraft will, at its expense, supply Senomyx with  [***] Tastants for screening. During the [***]
 Phase,
Kraft may provide additional purified [***] Tastants for profiling as agreed to in writing by the parties and approved by the
Steering Committee. 

        (C)  Upon
receipt of the [***] Tastants, Senomyx will perform the activities outlined in the Research
Plan using reasonable efforts, and the resources provided under Section 9.1. 

        (D)  Within  [***] of receipt of the report regarding the  [***] Compounds, Kraft
will perform sensory testing and other evaluations on a limited number of the  [***] Compounds; and may select [***] Compound(s) for
further development by notifying Senomyx of such selection in writing by the end of such [***] period. Such  [***] period may be extended by agreement; such
agreement will not be unreasonably withheld.  [***] Compounds, if any, chosen for further development become Selected  [***] Compounds. 

        (E)  Senomyx's
obligations during the [***] Phase will be completed upon the earlier of
(i) Senomyx's submission of a written report to Kraft regarding [***] Compounds; or (ii) upon Senomyx's submission
of a written report to Kraft regarding [***] Compounds, provided that the Steering Committee determines that the identification
of [***] Compounds is reasonable. [***] If necessary,
Senomyx may provide additional optimization as agreed to in writing by the parties and approved by the Steering Committee. 

        3.3    Product Development and Commercialization.    

        (A)    Product Development.    Within  [***] of the selection of a Selected Compound, Kraft will
prepare a plan for Product Development for approval by the Steering
Committee, which will be attached as Appendix D to this Agreement, and incorporated into the Agreement by reference. Kraft will perform the Product Development outlined in Appendix D. 

        (B)    Product Commercialization.    Within  [***] of the completion of the Product Development plan,
Kraft will prepare a plan for Product Commercialization for approval by
the Steering Committee, which will be attached as Appendix D to this Agreement, and incorporated into the Agreement by reference. Kraft will perform the Product Commercialization outlined in
Appendix F. 

3

 

        (C)  Kraft
will be responsible, [***] for all formulation and regulatory approval of Products arising
out of this Agreement. [***] Senomyx will cooperate to the extent reasonably necessary to permit Kraft to perform the foregoing
activities. 

        (D)  If
Kraft elects to abandon, discontinue, or forgo development or commercialization of any Product or fails after a reasonable time to initiate development or
commercialization of any Product in any country pursuant to Appendix D, Kraft's licenses under Section 10 of this Agreement to such Product will terminate and the right to make, have
made, use, sell and have sold such Product in such particular country will revert to Senomyx. Kraft will have no obligation for the Product or country where Kraft's rights are terminated under this
Section 3.3. 

4.    Principal Scientists.    The principal scientists who will direct the
respective research and development responsibilities of each party will be designated in writing by the Parties at the first meeting of the Steering Committee. 

5.    Collaboration with an Affiliate or Third Party.    During the Term, Senomyx
will have the right to enter into the Collaborative Program with its Affiliates or with Third Parties including Collaborative Programs to discover compounds that  [***] Tastants and [***] Tastants for use outside the
applicable Field. 

6.    Law and Regulation.    The Compounds, Selected Compounds and Materials
provided by one party to the other under this Agreement must be used in compliance with all applicable laws and regulations. Senomyx and Kraft each certifies that it conducts tests  in vitro or other
tests that are only used for laboratory research purposes and that all Materials and chemicals that either party receives from the
other under this Agreement will actually be used for these purposes only. 

7.    Scientific and Management Authority.    Scientific and management authority
and responsibility for activities conducted under the Research Plan and Product Development and Commercialization will be governed by the Steering Committee; provided, however, that after the
Collaborative Period, the parties will agree in writing to appoint a new committee to manage the activities under this Agreement. 

8.    Reporting.    Each party will report to the other a written summary of results
of research and development work it carries out, if any, within [***]. Each party agrees to prepare and exchange written and
electronic reports concerning any results and data that must be used by either party as supporting information for any regulatory filings. The exchange of such report may be reasonably supplemented,
at the request of the party receiving a report, by correspondence and/or upon reasonable prior notice, visits to the other party's facilities. 

9.    Financial Terms.    

        9.1    Annual Research Support.    Each year during the Collaborative Period Kraft will pay Senomyx  [***] (which represents the full time equivalent of  [***] Senomyx scientists at an annual rate of [***] per
scientist based on [***] per year), such rate to be increased for inflation using the Aon Consulting/Radford Division report for
industry compensation each year; provided, however, that if in any calendar year the annual amount to be paid to Senomyx exceeds  [***], Kraft may elect, in its sole discretion, to decrease the number of
full time equivalents such that the annual amount to
be paid to Senomyx remains at [***]. These payments will be made in advance and, at a minimum, on an equal quarterly basis. The
first payment will be made within [***] following the Effective Date. These payments are inclusive of overhead, labor, and
supplies. These payments do not include (i) Kraft's costs associated with providing [***] Tastants and  [***] Tastants; (ii) the costs of any
unanticipated materials as requested and agreed to by the parties; or
(iii) the costs of high throughput screening over [***]. Additional funding, if any, will be proposed to the Steering
Committee and agreed to in writing by the parties. 

4

 

        9.2    Milestone Payments.    Kraft will pay Senomyx the following non-creditable,
non-refundable milestone payments within [***] of notification of the following milestone events: 

        (A)  [***]; 

        (B)  [***]; 

        (C)  [***]; and 

        (D)  [***]. 

        9.3    Royalty for [***] Products.    Kraft will pay to Senomyx the following earned royalties
during the Royalty Term: 

        (A)  With
respect to Net Sales during the first one year following the date of the first commercial sale of a  [***] Product(s), Kraft will pay Senomyx a royalty equal to  [***]
 on that portion of total annual Net Sales of  [***] Product(s) that is less than [***], adjusted
during the Royalty Term using the Consumer Price Index ("CPI"). The royalty rate of [***] for the first year will apply to each
Product Category, as described on Appendix C; 

        (B)  With
respect to Net Sales after the one year anniversary of the first commercial sale of a [***]
Product(s), Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net Sales of  [***] Product(s) that is less than [***], adjusted
during the Royalty Term using the CPI; and 

        (C)  At
any time, Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net
Sales of [***] Product(s) that is equal to or greater than  [***], adjusted during the Royalty Term using the CPI. 

        (D)  The
royalty rate for New Products will be negotiated at a future date and shall be separate and apart from the other royalty rates established for the  [***] Products. 

        9.4    Royalty for [***] Products.    Kraft will pay to Senomyx the following earned royalties
during the Royalty Term: 

        (A)  With
respect to Net Sales during the first one year following the date of the first commercial sale of a  [***] Product, Kraft will pay Senomyx a royalty equal to  [***] on that portion of total annual Net Sales of [***]
Product(s) that is less than [***], adjusted during the Royalty Term using the Consumer Price Index ("CPI"). The royalty rate of  [***] for the first year
will apply to each Product Category, as described on Appendix C; 

        (B)  With
respect to Net Sales after the one year anniversary of the first commercial sale of a [***]
Product, Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net Sales of  [***] Product(s) that is less than [***], adjusted
during the Royalty Term using the CPI; and 

        (C)  At
any time, Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net
Sales of [***] Product(s) that is equal to or greater than  [***], adjusted during the Royalty Term using the CPI. 

5

           9.5    Manufacturing and Capital Credits.    Kraft may in its sole discretion,
manufacture or enter into supply and
manufacturing agreements with a mutually agreed upon Third Party regarding Selected Compounds; provided however, Senomyx will have the first right of negotiation and refusal to manufacture any such
Selected Compounds, subject to provisions of cost, quality and quantity. If Kraft or a Third Party manufactures a Product(s)  [***]. 

        9.6    Payment Method.    The royalties due under Section 9 will be paid within thirty days after the end of
each calendar quarter period in which such royalties are earned during the Royalty Term for each Product. With each such quarterly payment, Kraft will furnish to Senomyx a royalty statement in
sufficient detail to permit confirmation of the accuracy of the royalty payment made, which sets forth on a country-by-country basis the relevant sales information, including
the total number of units of each such Product sold, Net Sales, the royalties payable in United States dollars, the method used to calculate the royalty, the exchange rate used and other information
employed to calculate Net Sales for such Product. 

        9.7    Currency of Payment.    All payments to be made under this Agreement, including the royalties payable to
Senomyx by Kraft, will be paid in United States dollars by wire transfer or other mutually acceptable means to a bank account designated by Senomyx. With respect to each quarter, for countries other
than the United States, whenever conversion of payments from any foreign currency are required, such conversion will be made at the rate of exchange reported in The Wall Street
Journal on the business day of the applicable reporting period. Translation of sales recorded in local currencies to United States dollars will be performed in a manner
consistent with Kraft's normal practices used to prepare its audited financial statements for internal and external reporting purposes, which uses a widely accepted published exchange rate. 

        9.8    Taxes Withheld.    Any income or other tax that Kraft, or any of its Affiliates is required by a government
agency to withhold and pay on behalf of Senomyx with respect to the royalties payable under this Agreement will be deducted from and offset against such royalties prior to remittance to Senomyx;
provided, however, that in regard to any tax so deducted, Kraft will give or cause to be given to Senomyx such assistance as may reasonably be necessary to enable Senomyx to claim exemption from or
credit for the tax so deducted, and in each case will promptly furnish to Senomyx proper evidence of the taxes paid on Senomyx's behalf. 

        9.9    Late Payment.    In the event that any payment, including royalty payments, due hereunder is not made when due,
the payment will accrue interest from that date due at the rate of [***]; provided, however, that in no event will such rate
exceed the maximum legal annual interest rate. The payment of such interest will not limit Senomyx from exercising any other rights it may have as a consequence of the lateness of any payment. 

        9.10    Records of Net Sales and Royalty Calculations.    During the Royalty Term and for a period of three years
thereafter, Kraft will keep complete and accurate records of sales and all other information necessary to calculate Net Sales of each Product in sufficient detail to allow the accrued royalties to be
determined accurately in accordance with United States generally accepted accounting principles. Senomyx, with reasonable written notice to Kraft, will have the right to cause Senomyx's nationally
recognized independent, certified public accountant to audit such records at the place or places of business where such records are customarily kept in order to verify the accuracy of the reports of
Net Sales and royalty payments. Such accountant must execute a confidentiality agreement prior to entering Kraft's premises, obligating such accountant to keep all information disclosed to it
confidential and will only be permitted to disclose to Senomyx the extent of any discrepancy between royalty payments made by Kraft under this Agreement and the actual royalty required to be so paid.
Senomyx will bear the full cost of such audit unless such audit discloses a variance of more than [***] from the amount of the
royalties due under this Agreement, in which event, Kraft will bear the full cost of such audit. In all events, Kraft will pay any underpayment with interest in accordance with 

6

 

Section 9.9.
Senomyx agrees not to disclose Confidential Information concerning royalty payments reports, and all other information learned in the course of an audit or inspection, except to
the extent necessary for Senomyx to enforce its rights under this Agreement or if disclosure is required by law. 

10.    Grants.    Subject to the terms and conditions of this Agreement, Senomyx
hereby grants to Kraft the following rights: 

        10.1    Grant of Rights regarding [***] Compounds and [***]
Products:    

        (A)  Senomyx
hereby grants to Kraft a non-exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the
Senomyx Technology solely to evaluate [***] Compound(s) in Field I; 

        (B)  Senomyx
hereby grants to Kraft a non-exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the
Senomyx Technology solely to use Selected [***] Compound(s) for non-commercial development; and 

        (C)  Senomyx
hereby grants to Kraft an exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the Senomyx Technology
to make, have made, use, sell, have sold, import and export [***] Products. 

        10.2    Grant of Rights regarding [***] Compounds and [***]
Products:    

        (A)  Senomyx
hereby grants to Kraft a non-exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the
Senomyx Technology solely to evaluate [***] Compound(s) in Field II; 

        (B)  Senomyx
hereby grants to Kraft a non-exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the
Senomyx Technology solely to use Selected [***] Compound(s) for non-commercial development; and 

        (C)  Senomyx
hereby grants to Kraft an exclusive, nontransferable (except as permitted under Section 10.4 and 18.12), worldwide license, under the Senomyx Technology
to make, have made, use, sell, have sold, import and export [***] Products. 

        10.3    Right to Negotiate License for New Products.    At any time, Kraft will have the right to negotiate an
exclusive, nontransferable, worldwide, royalty-bearing license under the Senomyx's Patents and Know-How to make, have made, use, sell, have sold, import and export New Products. The
parties will negotiate language in good faith for such license including the royalties on such New Products. 

        10.4    Limitations to Licenses.    Kraft may not sublicense its rights under Section 10 to Third Parties,
except for the purpose of entering into collaborative development agreements between any such Third Party and Kraft that provide the support, as is appropriate at the time, for research, development
or commercialization of Product, and as agreed to by Senomyx in writing. All rights granted by Senomyx to Kraft under Section 10 shall be subject to the timely payment by Kraft under
Section 9 of the Agreement. 

        10.5    Grant of Rights from Kraft to Senomyx.    For the sole purpose of conducting research under this Agreement,
Kraft hereby grants to Senomyx a fully paid, non-exclusive, worldwide, fully-transferable license, to use the Kraft Technology pursuant to the Research Plan, with the right to grant
sublicenses; provided, however, that any such sublicense shall be subject to the prior written approval of Kraft, which shall not be unreasonably withheld. 

        10.6    Notwithstanding the provisions contained within this Agreement, Kraft may, at any time, negotiate a license for the use
of Selected [***] Compounds outside the Field. However, the parties understand that any such license will be subject to Third
Party agreements entered into by Senomyx and the final decision to enter into such license shall be made by Senomyx, in its sole discretion. 

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11.   Ownership of Intellectual Property.  

        11.1    Transfer of Rights.    Senomyx retains all rights not expressly licensed or assigned in this Agreement. Except
as otherwise expressly provided in this Agreement, nothing in this Agreement is intended to convey or transfer ownership or the grant of any license or sublicense by one party to the other party of
any rights in any Confidential Information, Patent Rights or Know-How Controlled by a party. Except as expressly set forth in this Agreement, nothing in this Agreement will be construed to
grant manufacturing rights. 

        11.2    Senomyx Inventions.    Senomyx will own all Inventions and other Know-How made solely by its
employees and agents and all Patent Rights claiming such Inventions and other Know-How. Senomyx hereby irrevocably assigns to Kraft all interest in and to any such Inventions and other
Know-How that consist of improvements to Kraft Technology, subject to the licenses granted to Senomyx under Section 10. The parties will look to the definition of Kraft Technology
in order to determine whether any such Invention and Know-How is an improvement to Kraft Technology. In the event that Senomyx is legally unable to assign such rights to Kraft, then
Senomyx agrees either to waive the enforcement of such rights against Kraft and any sublicensees and assignees, or to grant Kraft an exclusive, irrevocable, perpetual, worldwide,
fully-paid license, with right to sublicense through multiple tiers of sublicense, to such rights. 

        11.3    Kraft Inventions.    Kraft will own all Inventions and other Know-How made solely by its employees
and agents, and all Patent Rights claiming such Inventions and other Know-How. Kraft hereby irrevocably assigns to Senomyx all interest in and to any such Inventions and other
Know-How that consist of improvements to Senomyx Technology, Compounds, or Selected Compounds, subject to the licenses granted to Kraft under Section 10. The parties will look to
the definition of Senomyx Technology in order to determine whether any such Invention and Know-How is an improvement to Senomyx Technology. In the event that Kraft is legally unable to
assign such rights to Senomyx, then Kraft agrees either to waive the enforcement of such rights against Senomyx and any sublicensees and assignees, or to grant Senomyx
an exclusive, irrevocable, perpetual, worldwide, fully-paid license, with right to sublicense through multiple tiers of sublicense, to such rights. 

        11.4    Joint Inventions.    All Inventions conceived jointly by employees or agents of Senomyx and employees or
agents of Kraft (the "Joint Inventions") and all Joint Patent Rights will be owned jointly by Kraft and Senomyx. Kraft hereby irrevocably assigns to Senomyx all interest in and to any Joint Inventions
that consist of improvement to Senomyx Technology, Compounds, or Selected Compounds and uses thereof, and all Joint Patent Rights claiming such Joint Inventions, subject to the licenses granted to
Kraft under Section 10. Senomyx hereby irrevocably assigns to Kraft all interest in and to any such Inventions and other Know-How that consist of improvements to Kraft Technology,
subject to the licenses granted to Senomyx under Section 10. In the event that Kraft is legally unable to assign such rights to Senomyx, then Kraft agrees either to waive the enforcement of
such rights against Senomyx and any sublicensees and assignees, or to grant Senomyx an exclusive, irrevocable, perpetual, worldwide, fully-paid license, with right to sublicense through
multiple tiers of sublicense, to such rights. In the event that Senomyx is legally unable to assign such rights to Kraft, then Senomyx agrees either to waive the enforcement of such rights against
Kraft and any sublicensees and assignees, or to grant Kraft an exclusive, irrevocable, perpetual, worldwide, fully-paid license, with right to sublicense through multiple tiers of
sublicense, to such rights. 

        11.5    Other Inventions.    Any Inventions not included in Sections 11.1, 11.2, 11.3, or 11.4 will be owned by their
inventors. 

        11.6    Inventorship and Assignment.    United States patent law will determine inventorship of patentable inventions.
Senomyx and Kraft agree to execute all documentation necessary to perfect all assignments of Inventions, Know-How and Patent Rights contemplated in this Agreement. 

8

 

        11.7    Markings.    At least [***] prior to
commercialization of the first Product, Kraft will consider whether Kraft will mark any Product with a Senomyx trademark or Senomyx patent. However, the parties understand that Kraft will make the
final decision in Kraft's sole discretion. 

12.   Treatment of Confidential Information; Publicity.  

        12.1    Confidentiality.    Subject to the terms and conditions of this Agreement, Senomyx and Kraft each agree that,
during the Term and for a period of [***] thereafter, it will keep confidential, and will cause its Affiliates to keep
confidential, all Confidential Information that is disclosed to it or to any of its Affiliates by the other party. Neither Senomyx nor Kraft nor any of their respective Affiliates will use the other
party's Confidential Information except as expressly permitted in this Agreement. 

        12.2    Disclosure to Related Parties.    Senomyx and Kraft each agree that any disclosure of the other party's
Confidential Information to any officer, employee, contractor, consultant, sublicensee or agent of the other party or to any of its Affiliates will be made only if and to the extent necessary to carry
out its responsibilities under this Agreement and to exercise the rights granted to it hereunder, will be limited to the extent consistent with such responsibilities and rights, and will be provided
only to such persons or entities who are under an obligation of confidentiality no less stringent than as set forth in this Agreement. Each party will use reasonable efforts to take such action, and
to cause its Affiliates to take such action, to preserve the confidentiality of each other's Confidential Information, which will be the same efforts as it would customarily take to preserve the
confidentiality of its own Confidential Information. 

        12.3    Return of Confidential Material Upon Termination.    Upon termination of this Agreement, each party, upon the
other party's request, will return or destroy all Confidential Information received from the other party pursuant to this Agreement, including all copies and extracts of documents, within thirty days
of the request of the other party; provided, however, one copy of the Confidential Information may be retained for legal purposes. 

        12.4    Exceptions to Confidential Information.    Confidential Information will not include any information, which
the receiving party can prove by competent written evidence: 

        (A)  is
now, or hereafter becomes, through no act or failure to act on the part of the receiving party, generally known or available; 

        (B)  is
known by the receiving party at the time of receiving such information, as evidenced by its records; 

        (C)  is
hereafter furnished to the receiving party without restriction as to disclosure or use by a Third Party lawfully entitled to furnish such information; 

        (D)  is
independently developed by the employees, agents or contractors of the receiving party without the aid, application or use of the disclosing party's Confidential
Information; or 

        (E)  is
the subject of a written permission to disclose provided by the disclosing party. 

        A
party may also disclose Confidential Information of the other party where required to do so by law or legal process; provided, however, that, in such event, the party required to
disclose such information must give advance written notice of such disclosure to the other party and must cooperate with the other party's efforts to seek, at the request and expense of the other
party, all confidential treatment and protection for such disclosure as is permitted by applicable law. 

9

           12.5    Confidential Financial Information.    The parties agree that the material
financial terms of this Agreement
will be considered Confidential Information of both parties. Notwithstanding the foregoing, either party may disclose such terms in legal proceedings or as are required to be disclosed in its
financial statements, by law, or under an obligation of confidentiality to bona fide potential sublicensees. Either party will have the further right to disclose the material financial terms of this
Agreement under an obligation of confidentiality to any potential acquirer, merger partner, bank, venture capital firm, or other financial institution to obtain financing. Notwithstanding the
foregoing, the parties will mutually agree upon a press release consistent, in form and content, with the draft press release attached as Appendix E. Thereafter, Kraft and Senomyx may each
disclose to Third Parties the information contained in such press release without the need for further approval by the other party. 

        12.6    Confidential Research Information.    Each party agrees that all results and data generated from the research
under the Collaborative Program will be owned exclusively by the generating party and considered Confidential Information of the generating party subject to the confidentiality requirements of
Section 12. Neither Kraft nor Senomyx will provide to a Third Party any Materials provided by the other party. 

        12.7    Permitted Use and Disclosures.    Each party may use or disclose Confidential Information disclosed to it by
the other party to the extent such information is included in the Kraft Technology, Senomyx Technology or Joint Patent Rights, and to the extent such use or disclosure is reasonably necessary and
permitted in the exercise of the rights granted hereunder in filing or prosecuting patent applications, prosecuting or defending litigation, complying with applicable governmental regulations, or
court orders or otherwise submitting information to tax or other governmental authorities, conducting clinical trials, submitting information for food additive approval applications, or making a
permitted sublicense or otherwise exercising rights expressly granted to the other party pursuant to the terms of this Agreement; provided, however, that if a party is required to make any such
disclosure of the other party's Confidential Information, other than pursuant to a confidentiality agreement, it will give reasonable advance notice of such disclosure to the other party where
reasonably possible and, save to the extent inappropriate in the case of patent applications, will use its reasonable efforts to secure confidential treatment of such Confidential Information in
consultation with the other party prior to such disclosure (whether through protective orders or otherwise) and disclose only the minimum necessary to comply with such requirements. 

        12.8    Use of Data for Promotional Purposes.    Either party may (i) make public statements regarding
Compounds, Selected Compounds or Products, following consultation with the other party and with the written consent of the other party to the form and content of the public statement. Such public
statement shall be consistent with the press release attached as Appendix E. 

        12.9    Publication of Results.    Subject to this Section 12, results and data obtained by either party in the
course of the collaboration may be submitted for publication by Senomyx in accordance with Senomyx's customary practices. Senomyx will send a copy of the proposed publication to Kraft and will allow
Kraft [***] from the date of receipt in which to determine whether such publication contains subject matter for which patent
protection should be sought prior to disclosure, or otherwise contains Kraft Confidential Information. If no answer is received from Kraft within  [***] of receipt of the proposed publication, Senomyx
will be free to submit such proposed publication. 

        12.10    Publicity.    Except as required by law and as provided in this Section 12, neither party may make any
public announcement or otherwise disclose the terms of this Agreement without the prior written consent of the other party, which consent will not be unreasonably withheld. 

10

 

13.   Intellectual Property Enforcement and Defense of Claims.  

        13.1    Intellectual Property Enforcement.    Subject to the Third Party obligations of Senomyx, each party will have
the right, but not the obligation, to bring proceedings against any Third Party for the inappropriate use, including patent infringement, of Patent Rights solely Controlled by it, at its own risk and
expense. If either party brings such an action, such party will be entitled to control such action, hire and retain counsel, make decisions, settle on any terms, and retain any and all awards or
damages obtained in any such proceeding. At the request and expense of either party, the other party will give the requesting party all reasonable assistance required to file and conduct any such
proceeding. 

        13.2    Defense of Infringement Claims for Senomyx Technology.    Kraft will cooperate with Senomyx, at Senomyx's
expense, in the defense of any suit, action or proceeding against Kraft or Senomyx or Senomyx's Affiliates alleging the infringement of the intellectual property rights of a Third Party by reason of
Kraft's or Senomyx's use of any Senomyx Technology licensed to Kraft under this Agreement. The parties must notify each other promptly in writing of the commencement of any such suit, action,
proceeding or claim of infringement. At the expense of Senomyx, Kraft will give to Senomyx full and sole authority, information and assistance necessary to defend, hire counsel, make decisions or
settle on any terms any such suit, action or proceeding and Kraft will execute all documents, provide pertinent records, and take all other actions, including requiring persons within its control to
give testimony, which may be reasonably required in connection with the defense or settlement of such litigation. 

        13.3    Defense of Infringement Claims for Kraft Technology.    Senomyx will cooperate with Kraft, at Kraft's expense,
in the defense of any suit, action or proceeding against Senomyx or Kraft or Kraft's affiliates alleging the infringement of the intellectual property rights of a Third Party by reason of Kraft's or
Senomyx's use of any Kraft Technology licensed to Senomyx under this Agreement. The parties must notify each other promptly in writing of the commencement of any such suit, action, proceeding or claim
of infringement. At the expense of Kraft, Senomyx will give to Kraft full and sole authority, information and assistance necessary to defend, hire counsel, make decisions or settle on any terms any
such suit, action or proceeding and Senomyx will execute all documents, provide pertinent records, and take all other actions, including requiring persons within its control to give testimony, which
may be reasonably required in connection with the defense or settlement of such litigation. 

        14.    Patent Prosecution and Maintenance.    The control and expense of the filing, prosecution (including an
opposition or interference) and maintenance of Patent Rights or other intellectual property rights claiming Inventions made solely by a party will be the sole responsibility of the party that made
such Invention, and the party not filing the patent application will cooperate in such filing, prosecution and maintenance. Senomyx and Kraft will determine by mutual agreement which party will be
responsible for, and will cooperate in, the filing, prosecution and maintenance of Joint Patent Rights and will share equally in the expenses incurred with respect thereto. 

15.   Term and Termination.  

        15.1    Term.    The term of this Agreement will begin on the Effective Date and will continue through the end of the
Royalty Term, unless terminated earlier in accordance with the provisions of Section 15.2, 15.3 or 15.4 hereof (the "Term"). 

        15.2    Termination by Kraft.    Kraft will have the right to terminate this Agreement without cause at any time upon
sixty days written notice, provided, however, if such termination occurs prior to the end of the Collaborative Period Kraft must provide research funding in accordance with Section 9.1 for a
period of [***] from the date of written notice of termination. 

        15.3    Termination By Mutual Agreement.    The parties may terminate this Agreement at any time, in whole or in part,
by mutual written agreement executed by both parties. 

11

 

        15.4    Termination for Breach.    Either party has the right to terminate this Agreement at any time for a material
breach of this Agreement by the other party, provided that the breaching party has not cured such breach within sixty days after written notice thereof by the non-breaching party. The
non-breaching party, upon termination of this Agreement, may seek actual or general damages and remedies available to it at law or in equity. NEITHER PARTY WILL SEEK PUNITIVE OR
CONSEQUENTIAL DAMAGES. 

16.   Effect of Termination.  

        16.1    Upon termination of this Agreement pursuant to Section 15, Kraft will have no right to practice within or use of
the Senomyx Technology, and all rights, title and interest in and to the Senomyx Technology will revert to and become the sole property of Senomyx, unless otherwise agreed upon in writing by the
parties on or before the effective date of such termination. 

        16.2    Expiration or termination of this Agreement will not relieve the parties of any obligation accruing prior to such
expiration or termination. 

        16.2    Survival.    The obligations and rights of the parties under Sections 9.10, 11.2 through 11.7, 12, 16,
17.2(B), 17.3, 17.4(B), 17.5, 18, and Appendix A, will survive termination or expiration of this Agreement. 

17.   Warranties and Indemnification.  

        17.1    Mutual Representations and Warranties.    The parties make the following representations and warranties to
each other: 

        (A)    Corporate Power.    Each party hereby represents and warrants that as of the Effective
Date such party (i) is duly organized and validly existing under the laws of the state of its incorporation and has full corporate power and authority to enter into this Agreement and to carry
out the provisions hereof; (ii) has the requisite power and authority and the legal right to own and operate its property and assets, to lease the property and assets it operates under lease,
and to carry on its business as it is now being conducted; and (iii) is in compliance with all requirements of applicable law, except to the extent that
any noncompliance would not have a material adverse effect on its ability to perform its obligations under this Agreement. 

        (B)    Due Authorization.    Each party hereby represents and warrants that as of the
Effective Date such party (i) has the requisite power and authority and the legal right to enter into this Agreement and to perform its obligations hereunder; and (ii) has taken all
necessary action on its part to authorize the execution and delivery of this Agreement and to authorize the performance of its obligations hereunder and the grant of rights extended by it hereunder. 

        (C)    Binding Agreement.    Each party hereby represents and warrants to the other that as of
the Effective Date (i) this Agreement has been duly executed and delivered on its behalf and is a legal and valid obligation binding upon it and is enforceable in accordance with its terms;
(ii) the execution, delivery and performance of this Agreement by such party does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by
which it may be bound, nor violate any law or regulation of any court, governmental body or administrative or other agency having authority over it; and (iii) all necessary consents, approvals
and authorizations of all governmental authorities and other persons required to be obtained by it in connection with the Agreement have been obtained. 

12

 

        17.2    Warranties Regarding Senomyx Technology.    Senomyx warrants to Kraft as of the Effective Date the following:

        (A)  To
the best knowledge of Senomyx as of the Effective Date: (i) Senomyx has the lawful right to use the Senomyx Technology for the purpose of discovering Compounds
to be licensed to Kraft in accordance with the terms of this Agreement; and (ii) no Third Party suit exists relating to the Senomyx Patent Rights. 

        (D)  EXCEPT
AS EXPRESSLY SET FORTH IN THIS AGREEMENT, SENOMYX (INCLUDING ITS OFFICERS, EMPLOYEES AND AGENTS) EXPRESSLY DISCLAIMS ANY REPRESENTATIONS AND WARRANTIES, WHETHER
EXPRESS OR IMPLIED, RELATING TO SENOMYX TECHNOLOGY. SENOMYX FURTHER DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY (i) OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF SENOMYX TECHNOLOGY OR
SENOMYX PATENT RIGHTS; (ii) THAT THE PRACTICE OF SENOMYX TECHNOLOGY WILL NOT INFRINGE A PATENT, COPYRIGHT, TRADEMARK OR OTHER RIGHT OF A THIRD PARTY; AND (iii) REGARDING THE
PATENTABILITY OF ANY SENOMYX TECHNOLOGY, INCLUDING SENOMYX TECHNOLOGY CLAIMED IN PATENT APPLICATIONS AS PART OF SENOMYX PATENT RIGHTS. 

        17.3    Senomyx Indemnification.    Senomyx hereby agrees to defend and indemnify Kraft, and its respective officers,
directors, employees, and agents (collectively, the "Kraft Indemnitees") from and against all damages or other amounts payable to a Third Party, including reasonable attorneys' fees and costs of
litigation, resulting from a claim, demand, action, suit or other proceeding brought or threatened by a Third Party against a Kraft Indemnitee based on Senomyx's gross negligence or willful misconduct
(but not patent infringement) relating to Senomyx's performance or failure to perform under this Agreement. IN NO EVENT WILL SENOMYX BE LIABLE FOR ANY INCIDENTAL OR CONSEQUENTIAL DAMAGES SUFFERED BY
KRAFT RESULTING FROM THIS AGREEMENT. 

        17.4    Warranties Relating to Kraft Technology.    Kraft represents and warrants to Senomyx as of the Effective Date
the following: 

        (A)  To
the best knowledge of Kraft: (i) Kraft has the lawful right to license (or sublicense, as the case may be) the Kraft Technology to Senomyx in accordance with
the terms of this Agreement; and (ii) no Third Party suits against Kraft exist relating to the Kraft Patent Rights. 

        (B)  EXCEPT
AS EXPRESSLY SET FORTH IN THIS AGREEMENT, KRAFT (INCLUDING ITS OFFICERS, EMPLOYEES AND AGENTS) EXPRESSLY DISCLAIMS ANY REPRESENTATIONS AND WARRANTIES OF ANY KIND,
WHETHER EXPRESS OR IMPLIED, RELATING TO KRAFT TECHNOLOGY. KRAFT FURTHER (C) DISCLAIMS ANY EXPRESS OR IMPLIED WARRANTY (i) OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF KRAFT
TECHNOLOGY, (ii) THAT THE PRACTICE OF KRAFT TECHNOLOGY WILL NOT INFRINGE A PATENT, COPYRIGHT, TRADEMARK, OR OTHER RIGHT OF A THIRD PARTY, AND (iii) REGARDING THE PATENTABILITY OF ANY
KRAFT TECHNOLOGY, INCLUDING KRAFT TECHNOLOGY CLAIMED IN PATENT APPLICATIONS AS PART OF KRAFT PATENT RIGHTS. 

        17.5    Kraft Indemnification.    

        (A)    Of Senomyx.    Kraft hereby agrees to indemnify, defend and hold Senomyx, and its
respective officers, directors, employees and agents (collectively, the "Senomyx Indemnitees") harmless from and against all damages, losses, liabilities, expenses and costs or other amounts payable
to a Third Party, including reasonable attorneys' fees and costs of litigation, resulting from a claim, demand, action, suit or other proceeding brought or threatened by a Third Party against a 

13

 

Senomyx
Indemnitee based on (i) any development, manufacture, use, handling, storage, sale, or other disposition of a Selected Compound or Product by or through Kraft or its Affiliates or its
permitted sublicensees (ii) the practice by Kraft of any license granted hereunder, or (iii) infringement by Kraft of Patent Rights of any Third Party; except to the extent such damages
or other amounts payable are attributable to: (a) a violation of any contractual or fiduciary duty owed by any Senomyx Indemnitee to a Third Party, (b) any breach of this Agreement by a
Senomyx Indemnitee or a misrepresentation by Senomyx in this Agreement, or (c) trade secret misappropriation or patent infringement by Senomyx covered by a Third Party's Patent Rights. IN NO
EVENT WILL KRAFT BE LIABLE FOR ANY INCIDENTAL OR CONSEQUENTIAL DAMAGES SUFFERED BY SENOMYX RESULTING FROM THE EXERCISE OF ANY RIGHTS GRANTED IN ACCORDANCE WITH THIS AGREEMENT. 

        (B)    Of Certain Senomyx Licensors.    Kraft hereby agrees to indemnify, defend and hold  [***] and its respective officers,
sponsors, directors, employees, and agents (collectively, the "IP Indemnitees") harmless from
and against all damages or other amounts payable to a Third Party, including reasonable attorneys' fees and costs of litigation, resulting or arising from the exercise of rights under the licenses
granted from Senomyx to Kraft provided for under Section 10 and pursuant to any agreement between [***] and Senomyx,
including product liability. 

18.   Miscellaneous.  

        18.1    Force Majeure.    Neither party will lose any rights hereunder or be liable to the other party for damages or
losses on account of failure of performance by the defaulting party (other than a payment default) if the failure is occasioned by war, fire, explosion, flood, (e.g. El Niño),
earthquake, strike, lockout, embargo, act of God, or any other similar cause beyond the control of the defaulting party; provided, however, that the party claiming force majeure has exerted all
reasonable efforts to avoid or remedy such force majeure and thereafter takes all reasonable steps to mitigate any such delay in performance hereunder and any damages that may be incurred by the other
party thereby. 

        18.2    Governing Law and Jurisdiction.    This Agreement will be governed by the laws of the State of California, as
such laws are applied to contracts entered into and to be performed entirely within such state. 

        18.3    Binding Effect.    This Agreement will be binding upon and inure to the benefit of the successors and
permitted assigns of the parties. Any assignment not in accordance with this Agreement will be void. 

        18.4    Dispute Resolution.    The parties recognize that disputes as to certain matters may from time to time arise
during the Term, which relate to either party's rights and/or obligations hereunder. It is the objective of the parties to establish procedures to facilitate the resolution of disputes arising under
this Agreement in an expedient manner by mutual cooperation and without resort to arbitration. The parties agree that prior to any arbitration concerning this Agreement, Senomyx's head of R&D and
Kraft's head of R&D will meet in person or by video-conferencing in a good faith effort to resolve any disputes concerning this Agreement. Within thirty days of a formal request by either party to the
other party, either party may, by written notice to the other party, have such dispute referred to their respective officers designated or their successors, for attempted resolution by good faith
negotiations, such good faith negotiations to begin within thirty days after such notice is received. Any dispute arising out of or relating to this Agreement which is not resolved between the parties
or the designated officers of the parties pursuant to this Section 18.4 will be resolved by final and binding arbitration conducted in San Diego, California (unless the parties mutually agree
to another location) in accordance with Sections 1282 through 1288 of the California Code of Civil Procedure. The arbitration will be conducted by three arbitrators who are knowledgeable in the
subject matter at issue in the dispute. One arbitrator will be selected by Senomyx, and one arbitrator will be selected by Kraft. The 

14

 

third
arbitrator will be selected by mutual agreement of the two arbitrators selected by the parties. In conducting the arbitration, the arbitrators will (i) determine what discovery will be
permitted, consistent with the goal of limiting the cost and time which the parties must expend for discovery (and provided that the arbitrators will permit such discovery they deem necessary to
permit an equitable resolution of the dispute), (ii) ensure that the total time of the arbitration from filing to a final decision or executed settlement agreement is less than six months, and
(iii) be able to decree any and all relief of an equitable nature, including, but not limited to, such relief as a temporary restraining order, a preliminary injunction, a permanent injunction,
specific performance or repletion of property. The arbitrators will also be able to award actual or general damages, but will not award any other form of damage (e.g., consequential, punitive or
exemplary damages). The parties will share equally the arbitrator's fees and expenses pending the resolution of the arbitration, unless the arbitrators, pursuant to their its right but not their
obligations, requires the non-prevailing party to bear all or any portion of the costs of the prevailing party. The decision of the arbitrators will be final and binding on the parties and
may be sued on or enforced by the party in whose favor it runs in any court of competent jurisdiction at the option of such party. Notwithstanding anything to the contrary in this Section 18.4,
either party may seek immediate injunctive or other interim relief from any court of competent jurisdiction with respect to any breach of Sections 10 or 12 hereof, or otherwise to enforce and protect
the Patent Rights, copyrights, trademarks, or other intellectual property rights Controlled by such party. In addition, arbitration will not be used to resolve disputes concerning Patent Rights.
Disputes concerning Patent Rights, including, but not limited to, disputes concerning patent ownership, claim language, claim scope and issues of validity will be settled in a court of law. Any
arbitration ruling that relies on an interpretation of Patent Rights will have no binding effect in a court of law on any Patent Rights related to this Agreement, unless such Patent Rights have been
adjudicated in a court of law. In no event will a demand for arbitration be made after the date when the institution of a legal or equitable proceeding based on such claim, dispute or other matter in
question would be barred by the applicable statute of limitations. 

        18.5    Severability.    If any term, covenant or condition of this Agreement or the application thereof to any party
or circumstance is, to any extent, held to be invalid or unenforceable, then the remainder of this Agreement, or the application of such term, covenant or condition to parties or circumstances other
than those as to which it is held invalid or unenforceable, will not be affected thereby and each term, covenant or condition of this Agreement will be valid and enforced to the fullest extent
permitted by law; the parties covenant and agree to renegotiate any such term, covenant or condition or the application thereof in good faith in order to provide a reasonably acceptable alternative to
the term, covenant or condition of this Agreement or the application thereof that is invalid or unenforceable, it being the intent of the parties that the basic purposes of this Agreement are to be
effectuated. 

        18.6    Independent Contractors.    It is expressly agreed that Kraft and Senomyx will be independent contractors and
that the relationship between the parties will not constitute a partnership or agency of any kind. Neither Kraft nor Senomyx will have the authority to make any statements, representations or
commitments of any kind, or to take any action, which will be binding on the other party, without the prior written authorization of the other party to do so. 

15

           18.7    Entire Agreement; Amendment.    This Agreement sets forth all of the
covenants, promises, agreements,
warranties, representations, conditions and understandings between the parties, and supersedes and terminates all prior agreements and understandings between the parties, with respect to the subject
matter hereof. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the parties other than as set forth in this
Agreement. No subsequent alteration, amendment, change or addition to this Agreement will be binding upon the parties unless reduced to writing and signed by the respective authorized officers of the
parties. This Agreement will not be strictly construed against either party. Any conflict between the terms set forth in the text of this Agreement and the terms of any Appendix hereto will be
resolved in favor of the text of this Agreement. 

        18.8    Waiver.    Except as specifically provided for in this Agreement, the waiver from time to time by either of
the parties of any rights or the failure to exercise any remedy will not operate or be construed as a continuing waiver of the same right or remedy or any of the other of such party's rights or
remedies provided in this Agreement. 

        18.9    Construction.    The term "Article" or "Section" can refer to any single paragraph level found in this
Agreement or any collection of multiple paragraphs thereunder. 

        18.10    No Third Party Beneficiaries.    No Third Party, including any employee of any party to this Agreement
(except as specifically provided in this Agreement), will have or acquire any rights by reason of this Agreement. Nothing contained in this Agreement will be deemed to constitute the parties partners
with each other or any Third Party. 

        18.11    Notices.    Any notices or communications provided for in this Agreement to be made by either party to the
other party must be in writing, in English, and will be made by prepaid air mail or overnight carrier with return receipt addressed to the other party at its address set forth below. Any such notice
or communication may also be given by hand, or facsimile to the appropriate designation. Notices will be sent: 

	If to Senomyx, to:	 	Senomyx, Inc.

11099 North Torrey Pines Road

La Jolla, CA 92037

Facsimile number: (858) 404-0750

Attention: Corporate Counsel with a copy to the President
	

If to KRAFT, to:	
 	

KRAFT Foods

Three Lakes Drive

Northfield, IL 60096

Facsimile number: 847-646-4431

Attention: Patent Counsel with a copy to VP of Research

        By
like notice, either party may specify or change an address to which notices and communications must be thereafter sent. Notices sent by mail, facsimile or overnight carrier will be
effective upon receipt and notices given by hand will be effective when delivered. 

        18.12    Assignment.    Notwithstanding any provision of this Agreement to the contrary, neither party may assign any
of its rights or obligations under this Agreement in any country to any Third Party without the prior written consent of the non-assigning party, which consent will not be unreasonably
withheld; provided, however, that either party may assign its rights and obligations under this Agreement without the consent of the other party (i) in connection with the transfer or sale of
all or substantially all of its assets, or (ii) to any Affiliate. In the event of such transaction, however, 

16

 

intellectual
property rights (including Know-How) of a party to such transaction other than one of the parties to this Agreement will not be included in the technology licensed under this
Agreement. Notwithstanding the foregoing, any such assignment to an Affiliate will not relieve the assigning party of its responsibilities for performance of its obligations under this agreement. This
Agreement will survive any merger or consolidation of either party with or into another party and no consent for any such merger, consolidation or similar reorganization will be required hereunder. 

        18.13    Counterparts.    This Agreement may be executed in two or more counterparts, each of which will be deemed an
original, but all of which together will constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties, through their authorized officers, have executed this Agreement as of the Effective Date. 

	KRAFT FOODS, INC.	 	 
	

By:	
 	

/s/  [***]      
	
 	

 
	

Title:	
 	

Senior V.P. R&D Quality
	
 	

 
	

Date:	
 	

December 6, 2000
	
 	

 
	
SENOMYX, INC.	
 	

 
	

By:	
 	

/s/  PAUL A. GRAYSON      
	
 	

 
	

Title:	
 	

President & CEO
	
 	

 
	Date:	 	December 6, 2000
	 	 

17

 
COLLABORATIVE RESEARCH AGREEMENT  

 APPENDIX A—DEFINITIONS  

        "Affiliate" means any corporation, company, partnership, joint venture, association or other entity, which directly or indirectly controls, is controlled by or is
under common control with a party. As used in this definition, the term "control" means direct or indirect beneficial ownership of more than fifty percent (or such lesser percentage which is the
maximum allowed to be owned by a foreign corporation in a particular jurisdiction) of the outstanding securities having voting rights for the election of directors in a corporation or of the
comparable equity interest in any other type of entity. 

        "Agreement"
means this agreement, together with all appendices attached hereto, as it may be amended or supplemented from time to time hereafter by a written agreement executed by
authorized representatives of both parties. 

        "[***] Compound(s)" means [***],
discovered in the course of the Collaborative Program that [***] Tastants that may be optimized and further tested for  [***] by Senomyx and for which
Senomyx will prepare a written report of data to be reviewed by Kraft. 

        "[***] Phase" means that part of the Collaborative Program wherein Senomyx will pursue the identification of  [***] Compounds. 

        "[***] Product(s)" means product(s) in Field II that incorporate Selected  [***] Compound(s). 

        "[***] Tastant(s)" means [***] is a
primary ingredient and that are provided by Kraft to Senomyx under this Agreement. 

        "Collaborative
Period" means the period beginning on the Effective Date and ending three years thereafter, unless terminated earlier in accordance with Section 3 or 15. The 

        Collaborative
Period will terminate after three years regardless of whether the Compound Research has been completed. 

        "Collaborative
Program" means a research program during the Collaborative Period to discover molecules that [***]
taste in Fields to be conducted pursuant to the Research Plan. 

        "Compound(s)"
means [***] Compound(s) and/or  [***] Compound(s). 

        "Confidential
Information" means all information, Inventions and Know-How disclosed by one party to the other party pursuant to this Agreement, including, without limitation,
information and material (whether or not patentable) regarding technology, products, research, development, manufacturing, marketing, finances, personnel or other business information or objectives
which is designated as confidential in writing by the disclosing party, whether by letter or by the use of an appropriate stamp or legend, prior to or at the time any such material, trade secret or
other information is disclosed by the disclosing party to the other party. Notwithstanding the foregoing to the contrary, Inventions, Know-How or other information which is orally,
electronically or visually disclosed by a party, or is disclosed in writing without an appropriate letter, stamp or legend, will constitute Confidential Information of a party if the disclosing party,
within thirty days after such disclosure, delivers to the other party a written document or documents describing the Inventions, Know-How or other information and referencing the place and
date of such oral, visual, electronic or written disclosure and the names of the persons to whom such disclosure was made. 

        "Control"
or "Controlled" means, with respect to intellectual property, possession by a party, as of the Effective Date or during the Collaborative Period, of the ability to grant a
license or sublicense in accordance with the terms of this Agreement, without violating the terms of any agreement by such party with any Third Party that is in effect on the Effective Date. 

        "Effective
Date" means the date that this Agreement is signed by the last party to sign below. 

18

 

        "Field
I" means the Product Category of [***]. 

        "Field
II" means the category of products containing [***] as a primary ingredients. 

        "Fields"
means collectively Field I and Field II. 

        "Invention"
means any invention, including any new and useful process, method, or composition of matter, or improvement thereto, whether or not patentable, made in the course of the
Collaborative Program. 

        "Joint
Invention" has the meaning set forth in Section 11.4. 

        "Joint
Patent Rights" means all Patent Rights containing one or more claims to a Joint Invention. 

        "Know-How"
means information and data, whether or not patentable, which is not generally known to the public, including, without limitation, designs, concepts, formulae,
software, techniques, practices, processes, methods, knowledge, skill, experience, expertise, technical information, Materials and data, including pharmacological, toxicological and clinical test
data, analytical and quality control data, patent and legal data or marketing, sales and manufacturing data. 

        "Kraft
Know-How" means, to the extent necessary for purposes of the activities to be conducted under this Agreement, all Know-How Controlled by Kraft, including,
but not limited to, formulations in which Selected Compounds are used, [***] and methods of incorporating and/or processing
Selected Compounds into Products. 

        "Kraft
Patent Rights" means, to the extent necessary for purposes of the activities to be conducted under this Agreement, all Patent Rights Controlled by Kraft, including, without
limitation, any Patent Rights containing one or more claims to an Invention made solely by employees or agents of Kraft, but excluding any Joint Patent Rights. 

        "Kraft
Technology" means Kraft Patent Rights and Kraft Know-How. 

        "Materials"
[***] including without limitation, Compounds and Selected Compounds. 

        "Net
Sales" means, with respect to a Product, the gross amount invoiced by Kraft and its Affiliates and/or permitted sublicensees on any sales or other transfer of the Product, less the
following items: 

           i)  trade,
quantity and cash discounts or rebates actually allowed with respect to such sales; 

          ii)  credits,
rebates, charge-back rebates, reimbursements or similar payments actually granted or given to wholesalers and other distributors, buying groups,
governmental agencies and other institutions, but only to the extent actually allowed; 

         iii)  credits
or allowances actually granted for rejection or return of Products previously sold; and 

          iv)  any
tax, tariff, duty or other governmental charge (other than an income tax) levied on the sale, transportation or delivery of a Product that is borne by the seller
thereof and deducted from sales under United States generally accepted accounting principles. 

        Net
Sales will be determined from the books and records of Kraft, its Affiliates and/or its permitted sublicensees, maintained in accordance with United States generally accepted
accounting principles. 

        "New
Product(s)" means any products outside those listed on Appendix C that incorporate Selected [***]
Compounds in Field I. 

        "Patent
Rights" means all rights associated with all U.S. or foreign (including regional authorities such as the European Patent Office) regular or provisional patents or patent
applications, including any continuation, continuation-in-part, or division thereof or any substitute application therefor or 

19

 

equivalent
thereof, and any patent issuing thereon, including any reissue, reexamination or extension thereof and any confirmation patent or registration patent or patent of additions based on any
such patent. 

        "Product(s)"
means [***] Product(s) and/or  [***] Product(s). 

        "Product
Category(ies)" means each category of [***] Products listed on Appendix C. 

        "Product
Development and Commercialization" means the program for development of a Product conducted during the term of this Agreement as provided under Section 3.5. 

        "Receptor"
or "Receptors" means [***].

        "Research
Plan" means the plan outlining the research to be performed during the Collaborative Program agreed to by the Steering Committee at the first meeting thereof within thirty days
of the Effective Date. 

        "Royalty
Term" means, in the case of any Product and as to any country, the period of time commencing on the first commercial sale for use or consumption of such Product in such country
and ending upon the date that is ten years after the date of such first commercial sale for use or consumption of such Product in such country. 

        "Selected
[***] Compound(s)" means those  [***] Compound(s) selected by Kraft for development, which are subject to certain payment and diligence provisions.

        "Selected
Compound(s)" means Selected [***] Compound(s) and/or Selected  [***] Compound(s). 

        "Selected
[***] Compound(s)" means those  [***] Compound(s) selected by Kraft for development, which are subject to certain payment and diligence provisions.

        "Senomyx
Know-How" means all Know-How related to the Collaborative Program, which is not covered by the Senomyx Patent Rights, but is necessary or appropriate for
purposes of the activities to be conducted under this Agreement, and which is Controlled by Senomyx as of the Effective Date or developed by Senomyx in the course of the Collaborative Program. 

        "Senomyx
Patent Rights" mean all Patent Rights that are necessary or appropriate for purposes of the activities to be conducted under this Agreement, and which are Controlled by Senomyx
as of the Effective Date or developed by Senomyx in the course of the Collaborative Program, but excluding any Joint Patent Rights. 

        "Senomyx
Technology" means the Senomyx Patent Rights, and Senomyx Know-How. 

        "[***] Compounds" means [***], discovered
in the course of the Collaborative Program that [***] Tastants  [***] and for which Senomyx will prepare a written report of data to be reviewed by Kraft.

        "[***] Phase" means that part of the Collaborative Program wherein Senomyx will pursue the identification of  [***] Compounds. 

        "[***] Product(s)" means any product(s) listed on Appendix C that incorporate Selected  [***] Compound(s). 

        "[***] Tastants" means molecules contained in  [***] provided by Kraft to Senomyx under this Agreement. 

        "Steering
Committee" has the meaning set forth in Section 2. 

        "Term"
has the meaning set forth in Section 15.1. 

        "Third
Party(ies)" means any party other than a party to this Agreement or an Affiliate of Senomyx or Kraft. 

20

 
COLLABORATIVE RESEARCH AGREEMENT  

 APPENDIX C—PRODUCT CATEGORIES  

[***]  

21

  

***Text Omitted and Filed Separately

with the Securities and Exchange Commission.

Confidential Treatment Requested

Under 17 C.F.R. Sections 200.80(b)(4),

200.83 and 230.406.  

 
 

FIRST AMENDMENT
  TO THE COLLABORATIVE
  RESEARCH AND LICENSE AGREEMENT
  BETWEEN SENOMYX AND KRAFT    
    

        THIS FIRST AMENDMENT TO THE COLLABORATIVE RESEARCH AND LICENSE AGREEMENT (the "First Amendment") is made by and
between SENOMYX, INC. ("Senomyx"), a Delaware corporation, having a principal place of business at 11099 North Torrey Pines Road,
La Jolla, California 92037, and KRAFT FOODS, INC ("Kraft"), a Delaware corporation, having offices at 801 Waukegan Road, Glenview, IL
60025. 

        WHEREAS,
Senomyx and Kraft entered into that certain Collaborative Research and License Agreement dated December 6, 2000 (the
"Agreement") to collaborate in a research program to (i) discover compounds that  [***]; and (ii) discover compounds that [***]
(capitalized terms used but not otherwise defined in this First Amendment shall have the meanings given such terms in the Agreement); and 

        WHEREAS,
Senomyx and Kraft wish to amend the Agreement in the manner set forth in this First Amendment. 

        NOW,
THEREFORE, in consideration of the foregoing premises and of the covenants, representations and agreements set forth below, the parties hereby agree to amend the Agreement as
follows: 

        I.    The first paragraph of Article 3 of the Agreement is hereby amended
and restated its entirety as follows: 

         "Collaborative Program.    The parties will collaborate in the conduct of the Collaborative
Program in
accordance with the Research Plan and the Product Development Plan during the Collaborative Period." 

        II.    Section 3.1 of the Agreement is hereby amended to include a new  Subsection 3.1.1 as stated herein. The numbering of all other sections of Article 3 will
remain unchanged. 

        "3.1.1.    [***] Phase.    

        (A)  Senomyx
will perform the activities outlined in the Research Plan using reasonable efforts and the resources provided under Section  9.1 of the Agreement as allocated in Section 3.2 (A). 

        (B)  Within
[***] of receipt of the report regarding the  [***] Compounds, Kraft will perform sensory testing and other evaluations on  [***]
 Compounds and may select a [***] Compound(s) for
further development by notifying Senomyx of such selection in writing by the end of such [***] period. Such  [***] period may be extended by agreement; such
agreement will not be unreasonably withheld.  [***] Compounds, if any, chosen for further development become Selected  [***] Compounds. 

        (C)  Senomyx's
obligations during the [***] Phase will be completed upon the earlier of
(i) Senomyx's submission of a written report to Kraft regarding [***] Compounds; or 

1

 

(ii) upon
Senomyx's submission of a written report to Kraft regarding [***] Compounds, provided that the Steering
Committee determines that the identification of [***] Compounds is reasonable.  [***] If necessary, Senomyx may provide additional optimization as agreed to
in writing by the parties and approved by the
Steering Committee." 

        III.    Section 3.3 of the Agreement is hereby amended and restated in
its entirety as follows: 

"Product Development and Commercialization.

        (A)    Product Development Plan.    The Steering Committee will approve a detailed Product
Development Plan which will be prepared by Senomyx within [***] of the selection of a Selected Compound under the applicable
Phase of the Collaborative Program. The Product Development Plan, which will outline the responsibilities of the parties, will be attached as Appendix D
to the Agreement, and incorporated into the Agreement by reference. 

        (B)    Product Commercialization Plan.    Within  [***] of selection of the Selected Compound, Kraft will prepare a plan for Product
Development for approval by the Steering
Committee. The Product Commercialization Plan, attached as Appendix F to the Agreement and incorporated by reference thereto, will include commercially
reasonable timelines and levels of diligence necessary for Kraft to maintain the co-exclusive license, as provided for under Section 10.1(A)
of this First Amendment herein. 

        (C)  Senomyx
will be responsible for all regulatory approval of all Selected Compounds, Product Compounds and Products arising out of this Agreement.  [***] Senomyx will perform all regulatory activities relating to
the manufacture, use or sale of any Product. All regulatory
filings made or filed by Senomyx for any Compound, Selected Compound, or Product will be owned exclusively by Senomyx. Kraft will cooperate to the extent reasonably necessary to permit Senomyx to
perform the foregoing activities. 

        (D)  If
Kraft elects to abandon, discontinue, or forgo development or commercialization of any Product or fails after a reasonable time to initiate development or
commercialization of any Product in any country pursuant to Appendix D, Kraft's licenses under Section 10 of the Agreement to such Product
will terminate and the right to make, have made, use, sell and have sold such Product in such particular country will revert to Senomyx. Kraft will have no obligation for the Product or country where
Kraft's rights are terminated under this Section 3.3." 

        IV.    Section 9.1 of the Agreement is hereby amended and restated in its
entirety as follows: 

         "Annual Research Funding.    Beginning on the First Amendment Effective Date (i) with
respect to
the [***] Phase and [***] Phase, collectively, Kraft
must pay Senomyx at an annual rate of [***] through December 5, 2003, and (ii) with respect to the  [***] Phase, Kraft must pay Senomyx at an
annual rate of  [***] through December 5, 2003, and commencing on December 6, 2003 Kraft must pay Senomyx at an annual rate of  [***] through
May 1, 2005, unless the parties enter into written agreement to extend research funding under the  [***] Phase or [***] Phase beyond December 5,
2003. Annual research funding rates must be increased for inflation using the Aon Consulting/Radford Division report for industry compensation each year; provided, however, that if in any calendar
year the annual amount to be paid to Senomyx exceeds [***], Kraft may elect, in its sole discretion, to decrease the number of
full time equivalents such that the annual amount to be paid to Senomyx remains at [***]. These payments will be made in advance
and, at a minimum, on an equal quarterly basis. The first payment for the [***] Phase will be made within ten days following the
First Amendment Effective Date. The first payment for the [***] Phase and  [***] Phase will be made within ten days following the First Amendment Effective
Date. These payments are inclusive of overhead,
labor, and supplies. These payments do not include (i) Kraft's 

2

 

costs
associated with providing [***] Tastants and [***]
Tastants; (ii) the costs of any unanticipated materials as requested and agreed to by the parties; or (iii) the costs of high throughput screening over  [***]. Additional funding, if any, will
be proposed to the Steering Committee and agreed to in writing by the parties." 

        V.    Section 9.2 of the Agreement is hereby amended and restated in its
entirety as follows: 

         "Milestone Payments.    Kraft will pay Senomyx the following non-creditable (unless
otherwise stated herein), non-refundable milestone payments within thirty days of notification of the following milestone events: 

        (A)  [***]; 

        (B)  [***]; 

        (C)  [***]; and 

        (D)  [***]." 

        VI.    Section 9.3 of the Agreement is hereby amended to include a new  Subsection 9.3.1 as stated herein. The numbering of all other sections of Article 9 will
remain unchanged. 

         "Royalty for [***] Products.    Kraft will pay to Senomyx the following earned
royalties during the Royalty Term: 

        (A)  With
respect to Net Sales during the first one year following the date of the First Commercial Sale of a  [***] Product(s), Kraft will pay Senomyx a royalty equal to  [***]
 on that portion of total annual Net Sales of [***]
Product(s) that is less than [***] million, adjusted during the Royalty Term using the Consumer Price Index
("CPI"). The royalty rate of [***] for the first year will apply to each
Product; 

        (B)  With
respect to Net Sales after the one year anniversary of the First Commercial Sale of a [***]
Product(s), Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net Sales of  [***] Product(s) that is less than [***], adjusted
during the Royalty Term using the CPI; and 

        (C)  At
any time, Kraft will pay Senomyx a royalty equal to [***] on that portion of total annual Net
Sales of [***] Product(s) that is equal to or greater than  [***], adjusted during the Royalty Term using the CPI." 

        VII.    Section 10.1(A) of the Agreement is hereby amended and restated
in its entirety as follows: 

"License Grants

        Senomyx
will grant to Kraft under the Target IP (i) a non-exclusive, nontransferable, worldwide license to evaluate  [***] Compound(s) in Field III; (ii) a non-exclusive, nontransferable,
worldwide license, subject to
payment and diligence provisions, to make or have made [***] Products in Field III; and (iii) a
co-exclusive, with one collaborator of Senomyx, nontransferable, worldwide license, subject to payment and diligence provisions, to use, sell,  [***] Products in the Field III." 

        VIII.    Section 15.2 of the Agreement is hereby amended and restated in its entirety as follows: 

         "Termination by Kraft.    Kraft will have the right to terminate this Agreement without
cause at any
time upon sixty days written notice, provided, however if such termination occurs prior to the end of the Collaborative Period Kraft must provide research funding in accordance with section 9.1
for [***] from the date of written notice of termination, provided that if the agreement is terminated by Kraft under this
Section 15.2 less than [***] from the end of the Collaborative 

3

 

Period
then Kraft must provide research funding in accordance with section 9.1 through the end of the Collaborative Period." 

        IX.    The following definitions of Appendix A of the Agreement are
hereby amended and restated herein. All other definitions in the Agreement will remain unchanged. 

        "First Amendment Effective Date" means the date below that the last party to this First Amendment signs this First Amendment. 

        "Collaborative Period" means (i) in the case of the [***]
Phase the period beginning on the Effective Date and ending three years thereafter, unless terminated earlier in accordance with Section 15; (ii) in the case of the  [***] Phase the period
beginning on the Effective Date and ending three years thereafter, unless terminated earlier in
accordance with Section 15; and (iii) in the case of the [***] Phase, the period beginning on the First Amendment
Effective Date and ending three years thereafter, unless terminated earlier in accordance with Section 15. 

        "Collaborative Program" means the program during the Collaborative Period to discover and develop Compounds. 

        "Compound(s)" means any one or all combinations of the following:  [***] Compound(s), [***] Compound(s), and  [***] Compound(s). 

        "Field III" means [***]. 

        "Fields" means collectively Field I, Field II and Field III. 

        "First Commercial Sale" means the first sale to a Third Party purchaser. 

        "Phase or Phases" means one of the three phases of the Collaborative Program, or
collectively the [***] Phase, the [***] Phase, and the  [***] Phase. 

        "Product Development and Commercialization" has the meaning set forth in
Section 3.3 of the Agreement wherein the parties' responsibilities for the activities under the Product Development Plan and the Product
Commercialization Plan are incorporated by reference. 

        "Product Commercialization Plan" has the meaning set forth in Section 3.3(B) of
this First Amendment. 

        "Product Development Plan" has the meaning set forth in Section 3.3(A) of this First
Amendment. 

        "Product(s)" means any one or all combinations of the following:  [***] Product(s), [***] Product(s), and  [***] Product(s). 

        "Research Plan" means a plan that outlines the research to be performed during each of the Phases of the Collaborative Program, to be
agreed to by the Steering Committee within thirty days of the initiation of each of the Phases of the Collaborative Program and will be completed upon the earlier of the end of the Collaborative
Period or the selection of the first Selected Compound for each of the Phases. 

        "Royalty Term" means (i) in the case of a [***] Product and
as to any country, the period of time commencing on the First Commercial Sale for use or consumption of such [***] Product in
such country and ending upon the date that is 10 years after the date of such First Commercial Sale for use or consumption of such  [***] Product in such country; (ii) in the case of a 
[***] Product and as to any country, the period of time commencing on the First Commercial Sale for use or consumption of such  [***] Product in such country and
ending upon the date that is 10 years after the date of such First Commercial Sale for
use or consumption of such [***] Product in such country; and (iii) in the case of  [***] Product(s) the earlier of the date that 

4

 

(a) there
no longer exists a Valid Claim in a Patent Right Controlled by Senomyx or its Affiliates covering the manufacture, use or sale of such  [***] Product in any country in which the Product is sold; or
(b) the date that is seventeen years after the date of such
First Commercial Sale for use or consumption of such Product. 

        "Selected Compound(s)" means any one or all combinations of the following: Selected  [***] Compound(s), Selected [***]
Compound(s), and
Selected [***] Compound(s). 

        "Selected [***] Compound(s)" means those  [***] Compound(s) selected by Kraft for development, which are subject to certain payment and diligence provisions. 

        "[***] Compound(s)" means [***] compounds
Controlled by Senomyx, discovered in the course of the [***] Phase of the Collaborative Program that may be optimized and
further tested for selectivity and in vitro toxicity by Senomyx and for which Senomyx will prepare a written report of data to be reviewed by Kraft. 

        "[***] Phase" means that part of the Collaborative Program wherein Senomyx will pursue the identification of  [***] Compounds. 

        "[***] Product(s)" means any product listed under Category A on
Appendix C of the Agreement that incorporates Selected [***] Compounds. 

        "Target IP" means the Senomyx Patent Rights and Senomyx Know-How on the composition of matter and use of Compounds, Selected
Compounds and Products. 

        "Valid Claim" means an issued claim under an issued patent within the Patent Rights, which has not (i) expired or been canceled,
(ii) been declared invalid by an unreversed and unappealable decision of a court or other appropriate body of competent jurisdiction, (iii) been admitted to be invalid or unenforceable
through reissue, disclaimer or otherwise, and/or (iv) been abandoned." 

        X.    Miscellaneous.

         (1)    Except as specifically amended by this First Amendment, the terms and conditions of the Agreement shall remain in full force and
effect. 

        (2)    This First Amendment shall be governed by the laws of the State of California, as such laws are applied to contracts entered into
and to be
performed entirely within such state. 

         (3)    This First Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which
together shall
constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties have executed this First Amendment effective as of May 2, 2002. 

	SENOMYX, INC.	 	KRAFT FOODS, INC.
	

/s/  PAUL A. GRAYSON      
 Paul A. Grayson
 Chairman and CEO	
 	

/s/[***]

5

QuickLinks

COLLABORATIVE RESEARCH AND LICENSE AGREEMENT BETWEEN SENOMYX, INC. AND KRAFT FOODS, INC.

FIRST AMENDMENT TO THE COLLABORATIVE RESEARCH AND LICENSE AGREEMENT BETWEEN SENOMYX AND KRAFT

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