Document:

Amended & Restated Consulting & Scientific Advisory Board Agmt, Kucherlapati

 Exhibit 10.16 
 AMENDED AND RESTATED CONSULTING AND 
 SCIENTIFIC
ADVISORY BOARD AGREEMENT 
 AMENDED AND RESTATED CONSULTING AND SCIENTIFIC ADVISORY BOARD
AGREEMENT (the “Consulting Agreement”) dated as of this 1st day of January 2008, between AVEO PHARMACEUTICALS, INC., a Delaware corporation with offices at 75 Sidney Street, 4th Floor, Cambridge, MA 02139 (the “Company”) and Raju Kucherlapati, PhD residing at 6 Wildflower
Lane, Weston, MA 02493 (“Consultant”). 
 Whereas, the Company and the Consultant entered into that
certain Consulting Agreement on April 1, 2007 (the “Original Agreement”) pursuant to which Consultant has provided consulting services to the Company and served as a member of the Company’s Scientific Advisory Board (the
“SAB”); 
 Whereas, the Company and the Consultant wish to amend and restate the Original Agreement to, among other
things, (i) amend the term of the Original Agreement, and (ii) revise the Consultant’s compensation for services hereunder; 
 Now, Therefore, in consideration of the promises and mutual agreements hereinafter set forth, effective the date hereof, the Company and the Advisor hereby agree as follows: 
 The Company desires to engage Consultant to perform consulting services for the Company and Consultant desires to perform such services, on the terms and
conditions hereinafter set forth. 
 1. Academic Responsibility 
 It is recognized that as a member of the faculty and/or professional staff of Brigham and Women’s Hospital
(“BWH”) Partners HealthCare Systems, Inc. and Harvard Medical School (collectively, the “Institute”), Consultant is responsible for a variety of duties at the Institute and is subject, as is this
Agreement, to all requirements of the Institute’s Faculty Policy on Integrity in Science/Financial Conflicts of Interest and the BWH Patent Policy, which requirements may constrain in one or more than one aspects the performance of consulting
services hereunder. 
 2. Term 
 The period during which Consultant is engaged in a consulting relationship with the Company hereunder is
hereafter referred to as the “Consulting Period.” The Company agrees to retain Consultant, and Consultant agrees to serve, on the terms and conditions of this Agreement for a period commencing on the date hereof and ending on
December 31st, 2009, subject to earlier termination
as provided herein. This Agreement may be renewed by mutual consent of both parties. 

 3. Duties and Services 
 Consultant is hereby engaged on a non-exclusive basis to act as a general consultant to the Company in the field identified
on Schedule A attached hereto. Consultant’s duties shall be those identified on Schedule A attached hereto. 
 Consultant shall devote such time and energies as is reasonably necessary to fulfill his obligations hereunder, subject to his commitments to the Institute. Notwithstanding the foregoing, Consultant shall
devote 10 days per year, to be reasonably distributed over the year as shall be determined in good faith by the Board of Directors of the Company (the “Board”) or the senior management of the Company that may be designated by
the Board (the “Senior Management”), fulfilling his obligations hereunder (the “Time Commitment”). Service by the Consultant on the Board and the scientific advisory board of the Company shall qualify
towards satisfaction of the Consultant’s Time Commitment. 
 Consultant agrees that he will be available on
a reasonable basis for meetings and interactions with the Company. It is understood that Consultant shall be an independent contractor who may be engaged in other employment or who shall render other consulting services during the period of this
Consulting Agreement, subject to the limitations of Section 7 hereof. Such consulting services shall not involve any use of Institute facilities, space, materials or other resources, provided that Consultant may use the library and the
Consultant’s office. 
 4. Compensation As compensation for his services hereunder, the Company shall
pay Consultant, during the Consulting Period, as follows: 
 (i) $10,000 for each full-day (at least 8-hours)
meeting of the SAB attended by Consultant; 
 (ii) $3,000 for each half-day meeting of the SAB attended by
Consultant; and 
 (iii) $10,000 for each meeting of the SAB in which Consultant leads a discussion of specified
topics for such day (as determined in advance at the Company’s discretion). 
 Consultant acknowledges that as an independent contractor he
is not entitled to participate in or receive any benefit or right offered to Consultants of the Company under any Consultant benefit plan, including without limitation, medical and health insurance. Consultant acknowledges that the Company will not
withhold taxes on any amounts paid to him hereunder and that Consultant is responsible for all tax withholding, social security, unemployment insurance and other similar payments. 
 5. Expenses 
 Consultant shall be entitled to reimbursement for all reasonable, appropriate or necessary travel and other out-of-pocket expenses necessarily incurred in the performance of his duties hereunder in
accordance with the then-regular procedures of the Company; provided that any expenses in excess of $2,500 in any calendar quarter shall require written approval, which approval shall not be unreasonably denied or withheld. 
  

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 6. Representations and Warranties of Consultant 
 Consultant represents and warrants to the Company that, to the best of his knowledge, Consultant is under no contractual
restriction or obligation which is inconsistent with the execution of this Agreement, the performance of his duties hereunder, or the other rights of the Company hereunder except as set forth in Section 1. Consultant represents and warrants
that the Time Commitment contained in Section 3 above is acceptable and consistent, in all respects, with his performance of contractual obligations for the Institute. Consultant represents and warrants that this Agreement has been reviewed by
the Institute and to the best of Consultant’s knowledge, the execution and performance of this Agreement is not inconsistent with and will not violate any policies or procedures of the Institute which are applicable to the Consultant.
Consultant represents and warrants that, to the best of his knowledge, the execution of this Agreement and the performance of his duties hereunder in no way conflicts with any non-disclosure or confidentiality agreement between the Consultant and
any third party. Consultant represents and warrants that Consultant has provided to the Company a list of all consulting agreements, confidentiality and non-disclosure agreements and assignment of inventions agreements to which Consultant is a
party. 
 7. No Conflict of Interest; Non-Competition. 
 (a) Consultant agrees not to incur any conflicting obligation without the prior written consent of AVEO. For the duration of
the Consultation Period and for two (2) years thereafter, Consultant will not engage in any activity that would compete with AVEO, including, becoming employed by, serving as a consultant for, or serving on an advisory board for another for-profit
enterprise that competes directly with AVEO, without the prior written consent of AVEO. Notwithstanding the foregoing, nothing in this Agreement is intended to limit or interfere with Consultant’s performance of his duties and responsibilities
to his employer. 
 Nothing in this Agreement shall be construed to restrict or limit the duties Consultant is
performing or may perform in the course of, or incidental to. Consultant’s appointment at the Institute, including but not limited to research sponsored by a third party commercial or governmental entity, nor shall anything in the agreement be
construed to restrict or limit Consultant’s right to serve as an advisor to any hospital, or to any governmental or not-for-profit organization. 
 (b) During the term of this Agreement and for a period of one (1) year commencing on the expiration or termination (if earlier) of this Agreement. Consultant will not solicit, entice, persuade or induce
any individual who is then, or has been within the preceding six-month period, an employee or consultant of the Company or any of its subsidiaries or affiliates to terminate his employment or consulting relationship with the Company or any of its
subsidiaries or affiliates or to become employed by or

  

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enter into contractual relations with any other individual or entity, and the Consultant shall not approach any such employee or consultant for any such purpose or authorize or knowingly approve
the taking of any such actions by any other individual or entity. The term “affiliate” shall mean any person or entity that directly, or indirectly through one or more intermediaries, is controlled or is controlled by, or is
under common control of the Company. 
 (c) Since a breach of the provisions of this Section 7 could not
adequately be compensated by money damages, the Company shall be entitled, in addition to any other right and remedy available to it, to an injunction restraining such breach or a threatened breach, and in either case no bond or other security shall
be required in connection therewith. Consultant agrees that the provisions of this Section 7 are necessary and reasonable to protect the Company in the conduct of its business. If any restriction contained in this Section 7 shall be deemed
to be invalid, illegal, or unenforceable by reason of the extent, duration, or geographical scope thereof, or otherwise, then the court making such determination shall have the right to reduce such extent, duration, geographical scope, or other
provisions hereof, and in its reduced form such restriction shall then be enforceable in the manner contemplated hereby. 
 (d) The provisions of this Section 7 shall survive any termination or expiration of this Agreement. 
 8. Patent, etc. 
 Any interest in patents, patent
applications, inventions, technological innovations, copyrights, copyrightable works, developments, discoveries, designs, processes, formulas, know-how, data and analysis, whether patentable or not which Consultant may conceive or reduce to practice
or author in the direct performance of consulting services to the Company under this Agreement and in the Field (“Inventions”), shall belong to the Company; provided, however, that in accordance with the
Institute’s Patent Policy, the Company shall not obtain any right in or respecting any Invention or related ideas and discoveries which: (a) received direct or indirect financial support from the Institute, including funding from any
outside source awarded to or administered by the Institute, or (b) made use of any space, facilities, materials or other resources of the Institute including resources provided in-kind by outside sources. Consultant shall disclose to the
Institute’s Office of Corporate Sponsored Research and Licensing, in confidence, all Inventions which are related to Consultant’s research, clinical, or educational activities at the Institute in order to provide the Institute an
opportunity to assess, together with the Company, whether the invention is subject to the provisions of this Section 8. As soon as a Consultant conceives of, reduces to practice or authors any Invention, he agrees immediately to communicate
such fact in writing to the Company, and forthwith upon request of the Company. Consultant shall assist in the execution of all such assignments and other documents (including applications for patents, copyrights, trademarks, and assignments
thereof) and take all such other action as the Company may reasonably request in order to (a) vest in the Company all Consultant’s right, title, and interest in and to Inventions which are the sole property of the Company, and (b) if
patentable or copyrightable, to obtain at Company expense patents or copyrights (including extensions

  

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and renewals) thereof in any and all countries in such name as the Company shall determine. Time devoted by the Consultant to satisfying the foregoing obligations shall qualify toward
satisfaction of the Consultant’s Time Commitment. The provisions of this Section 8 shall survive any termination or expiration of this Agreement. 
 9. Confidential Information 
 (a) All confidential or
proprietary information concerning the conduct, affairs, products, Inventions, plans, or other aspects of the Company’s business, prospects or assets or other information relating to the business of the Company or of any customer or supplier of
the Company which Consultant may obtain from the Company during the Consulting Period shall not (except in compliance with Section 10 herein) be published, disclosed, or made accessible by him to any other person, firm or corporation either
during or after the Consulting Period or used by him, either directly or indirectly, except during the Consulting Period in the business and for the benefit of the Company, in each case without prior written permission of the Company. Consultant
shall return all physical evidence of such confidential information to the Company prior to or at termination of his retention as a Consultant by the Company. Notwithstanding the foregoing, the Consultant’s legal counsel may retain a single
copy of the confidential information for archival purposes only to provide a record of disclosure for a period of five (5) years following the expiration or termination of this Agreement. As used in this Section 9 “confidential
information” shall mean any information developed by or on behalf of, or otherwise acquired by, the Company and regarded by the Company as confidential, except that information which: (i) is generally known and available to the
public; (ii) was known to Consultant prior to being obtained from Company hereunder; (iii) was lawfully given to Consultant by an independent third party; (iv) was developed by or on behalf of Consultant independent of being obtained
from Company hereunder, (v) becomes public knowledge without breach by Consultant of any obligations of confidence to the Company, (vi) Consultant is obligated to produce by operation of law, or (vii) is necessary to disclose for the
protection of patient safety or prevention of imminent danger to the public. 
 (b) The provisions of this
Section 9 shall survive the expiration or termination of this Agreement for a period of five (5) years. 
 (c) The rights of the Company, and the obligations of the Consultant set forth in Sections 7(a), 8, and 9, including without limitation any interest in Inventions, are subject to and limited by rights of the Institute, including without
limitation any interest in Inventions, growing out of its relationship with Consultant. 
 10. Publications

 The Consultant shall provide the Company with an early draft copy of any proposed publication of research
results within the Field or any other such area that may be competitive with the business of the Company. If the Company informs the Consultant, within fifteen (15) days of receipt of an advance copy of a proposed publication which conveys the
content of a final

  

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publication that such publication in its reasonable judgment could be expected to have a material adverse effect on any of its intellectual properly, the Consultant shall, to the extent permitted
by the policies and procedures of the Institute and any agreements to which he is a party, delay or prevent such publication as proposed for a period not to exceed thirty (30) days to permit the timely preparation and filing of a patent
application(s) or application(s) for a certificate of invention on the information involved; provided that the Company will use its reasonable best efforts to review and prepare and file any such patent application(s) or application(s) for a
certificate of invention as quickly as quickly as possible. 
 11. Termination 
 (a) Notwithstanding anything herein contained, on or after the date hereof and prior to the end of the Consulting Period:

  

	 	(i)	either party may terminate this Agreement at any time without cause, upon 30 days written notice, or immediately upon Cause. 

  

	 	(ii)	this Agreement shall terminate automatically if Consultant shall be unable to discharge his duties hereunder by reason of any medically determinable physical or mental
impairment which can be expected to result in death or which has lasted for a period of not less than nine months in any eighteen month period. 

  

	 	(iii)	this Agreement shall terminate, if the Consultant shall die, on the date of Consultant’s death. 

 For the purposes of this Agreement, “Cause” for termination shall be deemed to exist upon (a) a good faith
finding by the Board, of the willful failure by the Consultant to perform the Time Commitment, (b) a good faith finding by the Board of material failure by the Consultant to perform Duties as requested the Board or Senior Management,
(c) Consultant’s intentional or reckless disregard of the rules or policies of the Company made known to him, or material breach of any agreement with the Company (including this Agreement), (d) a good faith finding by the Board,
material dishonesty, gross negligence, material misconduct or fraud on the part of the Consultant, or (e) the conviction of the Consultant of, or the entry of a pleading of guilty or nolo contendere by the Consultant to any crime involving
moral turpitude or any felony: provided that, in the case of clauses (a), (b) or (c) above, the Consultant shall be given written notice of such failure and a period of fifteen (15) business days to remedy such failure, with the
determination as to whether such remedy has occurred to be made solely by the Board, acting in good faith and exercising reasonable judgement. 
 12. Survival 
 Sections 7. 8. 9. 19. and 20 hereof
shall survive termination of this Agreement. 
  

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 13. Entire Agreement; Modification 
 This Agreement sets forth the entire understanding of the parties with respect to the subject matter hereof, supersedes all
existing agreements between them concerning such subject matter, and may be modified only by a written instrument duly executed by each party. 
 14. Notices 
 Any notice or other communication
required or permitted to be given hereunder shall be in writing and shall be mailed, return receipt requested, or delivered against receipt to the party to whom it is to be given at the address of such party set forth in the preamble to this
Agreement (or to such other address as the party shall have furnished in writing in accordance with the provisions of this Section 14). Notice to the estate of Consultant shall be sufficient if addressed to Consultant as provided in this
Section 14. Any notice or other communication given by certified mail shall be deemed given three days after the time of certification thereof, except for a notice changing a party’s address which shall be deemed given at the time of
receipt thereof. 
 15. Waiver 
 Any waiver by either party of a breach of any provision of this Agreement shall not operate as or be construed to be a waiver
of any other breach of such provision or of any breach of any other provisions of this Agreement. The failure of a party to insist upon strict adherence to any term of this Agreement on one or more occasions shall not be considered a waiver or
deprive that party of the right thereafter to insist upon strict adherence to that term or any other term of this Agreement. Any waiver must be in writing, signed by the party giving such waiver. 
 16. Binding Effect 
 Consultant’s rights and obligations under this Agreement shall not be transferable by assignments or otherwise. The provisions of this Agreement shall be binding upon and inure to the benefit of
Consultant and his heirs and personal representatives, and shall be binding upon and inure to the benefit of the Company and its successors and assigns. The term successors and assigns shall include any Company, partnership, association or other
entity which buys all or substantially all of the Company’s assets, stock or with which it merges or consolidates. 
 17. Headings 
 The headings in this Agreement are solely for the convenience of reference
and shall be given no effect in the construction or interpretation of this Agreement. 
  

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 18. Counterparts; Governing Law 
 This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. It shall be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts, without giving effect to the conflict of laws. 
 19. Use of Name 
 Neither the name of the Consultant nor that of BWH, nor Partners HealthCare System, nor any variation thereon nor any variation thereon nor adaptation thereof may be used in any advertising, promotional
or sales literature, or other publicity without the prior written approval of the party whose name is to be used, which approval shall not be unreasonably withheld. 
 20. Indemnification 
 The Company shall indemnify,
defend and hold harmless Consultant and Consultant’s successor, heirs and assigns and BWH and its trustees, employees and staff (“Indemnitees”) against any liability, damage, loss or expense (including reasonable
attorneys’ fees and expenses of litigation) incurred by or imposed upon the Indemnitees or any one of them in connection with any claims, suits, actions, demands other than any liability, damage, loss or expense resulting from Indemnitee’s
bad faith, wrongful misconduct or gross negligence or judgements arising from the good faith performance of the consulting services by Consultant. 
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 IN WITNESS WHEREOF, the parties have duly executed this Agreement as of the date
first above written. 
  

					
	AVEO PHARMACEUTICALS, INC.	 		 	CONSULTANT
			
	/s/ Tuan Ha-Ngoc	 		 	/s/ Raju Kucherlapati
	Name: Tuan Ha-Ngoc	 		 	Raju Kucherlapati, PhD
	 Title: President and Chief Executive Officer
	 		 	

  

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 Schedule A 
 For purposes of this Consulting Agreement, 
 “Field” shall mean to assist
the Company in the discovery and development of cancer therapeutics and diagnostics on a non-exclusive basis. 
 “Duties” shall mean: 
  

	 	(a)	Membership on the Company’s Scientific Advisory Board (“SAB”), including, but not limited to: 

  

	 	•	 	 attendance in person and participation in meetings at least twice per year; 

  

	 	•	 	 providing strategic scientific guidance to the Company regarding product and technology development programs; 

  

	 	•	 	 providing ideas and concepts for new product areas and make recommendations on future scientific directions; and 

  

	 	•	 	 providing contacts within the scientific community. 

  

	 	(b)	Attendance at outside meetings and participation in telephone discussions, including, but not limited to: 

  

	 	•	 	 regulatory discussions; 

  

	 	•	 	 corporate development meetings; and 

  

	 	•	 	 fund raising meetings. 

  

	 	(c)	Assistance with recruiting, including, but not limited to: 

  

	 	•	 	 suggest candidates for key positions in the Company; advisors and SAB members; and 

  

	 	•	 	 referencing on candidates. 

  

	 	(d)	Assistance with scientific matters, including, but not limited to: 

  

	 	•	 	 referring scientific information to the Company as appropriate. 

  

	 	(e)	Active participation in the recruiting of the Company’s principal research and development personnel, advisors and SAB members. 

  

	 	(f)	Provide scientific inspiration to the Company’s research and development personnel. 

  

	 	(g)	All such other matters as may be reasonably requested by the Board or Senior Management and agreed to by the Consultant from time to time. 

  

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 Exhibit 10.17 
 *LOAN 1000* 
 MASTER SECURITY AGREEMENT 
 dated as of December 8, 2003 (“Agreement”) 
 THIS AGREEMENT is between General Electric Capital Corporation (together with its successors and assigns, if any, “Secured
Party”) and Genpath Therapeutics, Inc. (“Debtor”). Secured Party has an office at 401 Merritt 7 Suite 23, Norwalk, CT 06851-1177. Debtor is a corporation organized and existing under the laws of the state of Delaware (“the
State”). Debtor’s mailing address and chief place of business is 300 Technology Drive, 7th Floor, Cambridge, MA 02139. 
  

	1.	CREATION OF SECURITY INTEREST. 

 Debtor grants to Secured Party, its successors and assigns, a security interest in and against all property listed on any collateral schedule and additional schedules now or in the future annexed to or made a part of this Agreement
(“Collateral Schedule”), and in and against all additions, attachments, accessories and accessions to such property, all substitutions, replacements or exchanges therefor, and all insurance and/or other proceeds thereof (all such property
is individually and collectively called the “Collateral”). This security interest is given to secure the payment and performance of all debts, obligations and liabilities of any kind whatsoever of Debtor to Secured Party, now existing or
arising in the future, including but not limited to the payment and performance of certain Promissory Notes from time to time identified on any Collateral Schedule (collectively “Notes” and each a “Note”), and any renewals,
extensions and modifications of such debts, obligations and liabilities (such Notes, debts, obligations and liabilities are called the “Indebtedness”). 
  

	2.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 

 Debtor represents, warrants and covenants as of the date of this Agreement and as of the date of each Collateral Schedule that: 
 (a) Debtor’s exact legal name is as set forth in the preamble of this Agreement and Debtor is, and will remain, duly organized,
existing and in good standing under the laws of the State set forth in the preamble of this Agreement, has its chief executive offices at the location specified in the preamble, and is, and will remain, duly qualified and licensed in every
jurisdiction wherever necessary to carry on its business and operations; 
 (b) Debtor has adequate power and capacity to enter
into, and to perform its obligations under this Agreement, each Note and any other documents evidencing, or given in connection with, any of the Indebtedness (all of the foregoing are called the “Debt Documents”); 
 (c) This Agreement and the other Debt Documents have been duly authorized, executed and delivered by Debtor and constitute legal, valid and
binding agreements enforceable in accordance with their terms, except to the extent that the enforcement of remedies may be limited under applicable bankruptcy and insolvency laws; 

 (d) No approval, consent or withholding of objections is required from any governmental
authority or instrumentality with respect to the entry into, or performance by Debtor of any of the Debt Documents, except any already obtained; 
 (e) The entry into, and performance by, Debtor of the Debt Documents will not (i) violate any of the organizational documents of Debtor or any judgment, order, law or regulation applicable to Debtor,
or (ii) result in any breach of or constitute a default under any contract to which Debtor is a party, or result in the creation of any lien, claim or encumbrance on any of Debtor’s property (except for liens in favor of Secured Party)
pursuant to any indenture, mortgage, deed of trust, bank loan, credit agreement, or other agreement or instrument to which Debtor is a party; 
 (f) There are no suits or proceedings pending in court or before any commission, board or other administrative agency against or affecting Debtor which could, in the aggregate, have a material adverse
effect on Debtor, its business or operations, or its ability to perform its obligations under the Debt Documents, nor does Debtor have reason to believe that any such suits or proceedings are threatened; 
 (g) All financial statements delivered to Secured Party in connection with the Indebtedness have been prepared in accordance with generally
accepted accounting principles, and since the date of the most recent financial statement, there has been no material adverse change in Debtors financial condition; 
 (h) The Collateral is not, and will not be, used by Debtor for personal, family or household purposes; 
 (i) The Collateral is, and will remain, in good condition and repair and Debtor will not be negligent in its care and use; 
 (j) Debtor is, and will remain, the sole and lawful owner, and in possession of, the Collateral, and has the sole right and lawful authority to grant the security interest described in this Agreement;

 (k) The Collateral is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever, except
for (i) liens in favor of Secured Party, (ii) liens for taxes not yet due or for taxes being contested in good faith and which do not involve, in the judgment of Secured Party, any risk of the sale, forfeiture or loss of any of the
Collateral, and (iii) inchoate materialmen’s, mechanic’s, repairmen’s and similar liens arising by operation of law in the normal course of business for amounts which are not delinquent (all of such liens are called
“Permitted Liens”); and 
 (l) Debtor is and will remain in full compliance with all laws and regulations applicable
to it including, without limitation, (i) ensuring that no person who owns a controlling interest in or otherwise controls Debtor is or shall be (Y) listed on the Specially Designated Nationals and Blocked Person List maintained by the
Office of Foreign Assets Control (“OFAC”), Department of the Treasury, and/or any other similar lists maintained by OFAC pursuant to any authorizing statute, Executive Order or regulation or (Z) a person designated under Section l(b),
(c) or (d) of Executive Order No. 13224 (September 23, 2001), any related enabling legislation or any other similar Executive Orders, and (ii) compliance with all applicable Bank Secrecy Act (“BSA”) laws, regulations
and government guidance on BSA compliance and on the prevention and detection of money laundering violations. 

	3.	COLLATERAL. 

 (a) Until
the declaration of any default, Debtor shall remain in possession of the Collateral; except that Secured Party shall have the right to possess (i) any chattel paper or instrument that constitutes a part of the Collateral, and (ii) any
other Collateral in which Secured Party’s security interest may be perfected only by possession. Secured Party may inspect any of the Collateral during normal business hours after giving Debtor reasonable prior notice. If Secured Party asks,
Debtor will promptly notify Secured Party in writing of the location of any Collateral. 
 (b) Debtor shall (i) use the
Collateral only in its trade or business, (ii) maintain all of the Collateral in good operating order and repair, normal wear and tear excepted, (iii) use and maintain the Collateral only in compliance with manufacturers recommendations
and all applicable laws, and (iv) keep all of the Collateral free and clear of all liens, claims and encumbrances (except for Permitted Liens). 
 (c) Secured Party does not authorize and Debtor agrees it shall not (i) part with possession of any of the Collateral (except to Secured Party or for maintenance and repair), (ii) remove any of
the Collateral from the continental United States, or (iii) sell, rent, lease, mortgage, license, grant a security interest in or otherwise transfer or encumber (except for Permitted Liens) any of the Collateral. 
 (d) Debtor shall pay promptly when due all taxes, license fees, assessments and public and private charges levied or assessed on any of the
Collateral, on its use, or on this Agreement or any of the other Debt Documents. At its option, Secured Party may discharge taxes, liens, security interests or other encumbrances at any time levied or placed on the Collateral and may pay for the
maintenance, insurance and preservation of the Collateral and effect compliance with the terms of this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on demand, all reasonable costs and expenses incurred by
Secured Party in connection with such payment or performance and agrees that such reimbursement obligation shall constitute Indebtedness. 
 (e) Debtor shall, at all times, keep accurate and complete records of the Collateral, and Secured Party shall have the right to inspect and make copies of all of Debtor’s books and records relating
to the Collateral during normal business hours, after giving Debtor reasonable prior notice. 
 (f) Debtor agrees and
acknowledges that any third person who may at any time possess all or any portion of the Collateral shall be deemed to hold, and shall hold, the Collateral as the agent of, and as pledge holder for, Secured Party. Secured Party may at any time give
notice to any third person described in the preceding sentence that such third person is holding the Collateral as the agent of, and as pledge holder for, the Secured Party. 

	4.	INSURANCE. 

 (a) Debtor
shall at all times bear the entire risk of any loss, theft, damage to, or destruction of, any of the Collateral from any cause whatsoever. 
 (b) Debtor agrees to keep the Collateral insured against loss or damage by fire and extended coverage perils, theft, burglary, and for any or all Collateral which are vehicles, for risk of loss by
collision, and if requested by Secured Party, against such other risks as Secured Party may reasonably require. The insurance coverage shall be in an amount no less than the full replacement value of the Collateral, and deductible amounts, insurers
and policies shall be reasonably acceptable to Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance evidencing such coverage. Each policy shall name Secured Party as a loss payee, shall provide for coverage to
Secured Party regardless of the breach by Debtor of any warranty or representation made therein, shall not be subject to co-insurance, and shall provide that coverage may not be canceled or altered by the insurer except upon thirty (30) days
prior written notice to Secured Party. Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance and adjustments with insurers, and to receive payment of and execute or endorse all documents, checks or drafts
in connection with insurance payments. Secured Party shall not act as Debtor’s attorney-in-fact unless Debtor is in default. Proceeds of insurance shall be applied, at the reasonable option of the Debtor, to repair or replace the Collateral or
to reduce any of the Indebtedness. 
  

	5.	REPORTS. 

 (a) Debtor
shall reasonably promptly notify Secured Party of (i) any change in the name of Debtor, (ii) any change in the state of its incorporation or registration, (iii) any relocation of its chief executive offices, (iv) any relocation
of any of the Collateral, (v) any of the Collateral being lost, stolen, missing, destroyed, materially damaged or worn out, or (vi) any lien, claim or encumbrance other than Permitted Liens attaching to or being made against any of the
Collateral. 
 (b) Debtor will deliver to Secured Party Debtor’s complete financial statements, certified by a recognized
firm of certified public accountants, within ninety (90) days of the close of each fiscal year of Debtor. If Secured Party requests, Debtor will deliver to Secured Party copies of Debtor’s quarterly financial reports certified by
Debtor’s chief financial officer, within ninety (90) days after the close of each of Debtor’s fiscal quarters. Debtor will deliver to Secured Party copies of all Forms 10-K and 10-Q, if any, within 30 days after the dates on which
they are filed with the Securities and Exchange Commission. 
  

	6.	FURTHER ASSURANCES. 

 (a)
Debtor shall, upon request of Secured Party, furnish to Secured Party such further information, execute and deliver to Secured Party such documents and instruments (including, without limitation, Uniform Commercial Code financing statements) and
shall do such other acts and things as Secured Party may at any time reasonably request relating to the perfection or protection of the security interest created by this Agreement or for the purpose of carrying out the intent of this Agreement.
Without limiting the foregoing, Debtor shall cooperate and do all acts deemed necessary or advisable by Secured Party to continue in Secured Party a

 
perfected first security interest in the Collateral, and shall obtain and furnish to Secured Party any subordinations, releases, landlord waivers, lessor waivers, mortgagee waivers, or control
agreements, and similar documents as may be from time to time reasonably requested by, and in form and substance reasonably satisfactory to, Secured Party. 
 (b) Debtor authorizes Secured Party to file a financing statement and amendments thereto describing the Collateral and containing any other information required by the applicable Uniform Commercial Code.
Debtor irrevocably grants to Secured Party the power to sign Debtor’s name and generally to act on behalf of Debtor to execute and file applications for title, transfers of title, financing statements, notices of lien and other documents
pertaining to any or all of the Collateral; this power is coupled with Secured Party’s interest in the Collateral. Debtor shall, if any certificate of title be required or permitted by law for any of the Collateral, obtain and promptly deliver
to Secured Patty such certificate showing the lien of this Agreement with respect to the Collateral. Debtor ratifies its prior authorization for Secured Party to file financing statements and amendments thereto describing the Collateral and
containing any other information required by the Uniform Commercial Code if filed prior to the date hereof. 
 (c) Debtor shall
indemnify and defend the Secured Party, its successors and assigns, and their respective directors, officers and employees, from and against all claims, actions and suits (including, without limitation, related reasonable attorneys’ fees) of
any kind whatsoever arising, directly or indirectly from the actions or failure to act of the Debtor, in connection with any of the Collateral, except as caused by Secured Party’s gross negligence or willful misconduct 
  

	7.	DEFAULT AND REMEDIES. 

 (a) Debtor shall be in default under this Agreement and each of the other Debt Documents if: 
 (i)
Debtor breaches its obligation to pay when due any installment or other amount due or coming due under any of the Debt Documents; 
 (ii) Debtor, without the prior written consent of Secured Party, attempts to or does sell, rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or encumber (except for
Permitted Liens) any of the Collateral; 
 (iii) Debtor breaches any of its insurance obligations under
Section 4; 
 (iv) Debtor breaches any of its other obligations under any of the Debt Documents and fails to
cure that breach within thirty (30) days after written notice from Secured Party; 
 (v) Any warranty,
representation or statement made by Debtor in any of the Debt Documents or otherwise in connection with any of the Indebtedness shall be false or misleading in any material respect; 

 (vi) Any of the Collateral is subjected to attachment, execution, levy,
seizure or confiscation in any legal proceeding or otherwise, or if any legal or administrative proceeding is commenced against Debtor or any of the Collateral, which in the good faith judgment of Secured Party subjects any of the Collateral to a
material risk of attachment, execution, levy, seizure or confiscation and no bond is posted or protective order obtained to negate such risk; 
 (vii) Debtor breaches or is in default under any other agreement between Debtor and Secured Party; 
 (viii) Debtor or any guarantor or other obligor for any of the Indebtedness (collectively “Guarantor”) dissolves, terminates its existence, becomes insolvent or ceases to do business as a going
concern; 
 (ix) If Debtor or any Guarantor is a natural person, Debtor or any such Guarantor dies or becomes
incompetent; 
 (x) A receiver is appointed for all or of any part of the property of Debtor or any Guarantor, or
Debtor or any Guarantor makes any assignment for the benefit of creditors; 
 (xi) Debtor or any Guarantor files
a petition under any bankruptcy, insolvency or similar law, or any such petition is filed against Debtor or any Guarantor and is not dismissed within forty-five (45) days; or 
 (xii) Debtor’s improper filing of an amendment or termination statement relating to a filed financing statement
describing the Collateral. 
 (b) If Debtor is in default under Section 7(a)(i) of this Agreement and such Default is not
cured within 30 days, the Secured Party, at its option, may declare any or all of the Indebtedness to be immediately due and payable, without demand or notice to Debtor or any Guarantor. The accelerated obligations and liabilities shall bear
interest (both before and after any judgment) until paid in full at the lower of eighteen percent (18%) per annum or the maximum rate not prohibited by applicable law. 
 (c) After default, Secured Party shall have all of the rights and remedies of a Secured Party under the Uniform Commercial Code, and under
any other applicable law. Without limiting the foregoing. Secured Party shall have the right to (i) notify any account debtor of Debtor or any obligor on any instrument which constitutes part of the Collateral to make payment to the Secured
Party, (ii) with or without legal process, enter any premises where the Collateral may be and take possession of and remove the Collateral from the premises or store it on the premises, (iii) sell the Collateral at public or private sale,
in whole or in part, and have the right to bid and purchase at said sale, or (iv) lease or otherwise dispose of all or part of the Collateral, applying proceeds from such disposition to the obligations then in default. If requested by Secured
Party, Debtor shall promptly assemble the Collateral and make it available to Secured Party at a place to be designated by Secured Party which is reasonably convenient to both parties. Secured Party may also render any or all of the Collateral
unusable at the Debtor’s premises and may dispose of such Collateral on such premises without liability for rent or costs. Any notice that Secured Party is required to give to Debtor under the Uniform Commercial Code of the time and place of
any public sale or the time after which any private sale or other intended disposition of the Collateral is to be made shall be deemed to constitute reasonable notice if such notice is given to the last known address of Debtor at least ten
(10) days prior to such action. 

 (d) Proceeds from any sale or lease or other disposition shall be applied: first, to all
reasonable costs of repossession, storage, and disposition including without limitation reasonable attorneys’, appraisers’, and auctioneers’ fees; second, to discharge the obligations then in default; third, to discharge any other
Indebtedness of Debtor to Secured Party, whether as obligor, endorser, guarantor, surety or indemnitor; fourth, to expenses incurred in paying or settling liens and claims against the Collateral; and lastly, to Debtor, if there exists any surplus.
Debtor shall remain fully liable for any deficiency. 
 (e) Debtor agrees to pay all reasonable attorneys’ fees and other
costs incurred by Secured Party in connection with the enforcement, assertion, defense or preservation of Secured Party’s rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be permitted. Debtor further
agrees that such fees and costs shall constitute Indebtedness. 
 (f) Secured Party’s rights and remedies under this
Agreement or otherwise arising are cumulative and may be exercised singularly or concurrently. Neither the failure nor any delay on the part of the Secured Party to exercise any right, power or privilege under this Agreement shall operate as a
waiver, nor shall any single or partial exercise of any right, power or privilege preclude any other or farther exercise of that or any other right, power or privilege. SECURED PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS
AGREEMENT OR UNDER ANY OTHER AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND SIGNED BY SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or waiver of any right or remedy on
any future occasion. 
 (g) DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF
ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY OF THE OTHER DEBT DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED
TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN DEBTOR AND SECURED PARTY. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES ARISING OUT OF THE AGREEMENT THAT MAY BE FILED IN ANY COURT. THIS
WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER
DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT. 
  

	8.	MISCELLANEOUS. 

 (a) This
Agreement, any Note and/or any of the other Debt Documents may be assigned, in whole or in part, by Secured Party without notice to Debtor, and Debtor agrees not to assert against any such assignee, or assignee’s assigns, any defense, set-off,
recoupment claim or counterclaim which Debtor has or may at any time have against Secured Party for any reason whatsoever.

 
Debtor agrees that if Debtor receives written notice of an assignment from Secured Party, Debtor will pay all amounts payable under any assigned Debt Documents to such assignee or as instructed
by Secured Party. Debtor also agrees to confirm in writing receipt of the notice of assignment as may be reasonably requested by Secured Party or assignee. 
 (b) All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective addresses set forth in this Agreement (unless and until a different
address may be specified in a written notice to the other party), and shall be deemed given (i) on the date of receipt if delivered in hand or by facsimile transmission, (ii) on the next business day after being sent by express mail, and
(iii) on the fourth business day after being sent by regular, registered or certified mail. As used herein, the term “business day” shall mean and include any day other than Saturdays, Sundays, or other days on which commercial banks
in New York, New York are required or authorized to be closed. 
 (c) Secured Party may correct patent errors and fill in all
blanks in this Agreement or in any Collateral Schedule consistent with the agreement of the parties. 
 (d) This Agreement shall
be binding, jointly and severally, upon ail parties described as the “Debtor” and their respective heirs, executors, representatives, successors and assigns, and shall inure to the benefit of Secured Party, its successors and assigns.

 (e) This Agreement and its Collateral Schedules constitute the entire agreement between the parties with respect to the
subject matter of this Agreement and supersede all prior understandings (whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND ITS COLLATERAL SCHEDULES SHALL NOT BE CHANGED OR TERMINATED ORALLY OR BY COURSE OF
CONDUCT, BUT ONLY BY A WRITING SIGNED BY BOTH PARTIES. Section headings contained in this Agreement have been included for convenience only, and shall not affect the construction or interpretation of this Agreement. 
 (f) This Agreement shall continue in full force and effect until all of the Indebtedness has been paid in full to Secured Party or its
assignee. The surrender, upon payment or otherwise, of any Note or any of the other documents evidencing any of the Indebtedness shall not affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then exist or as
it may be reasonably contemplated will exist in the future. This Agreement shall automatically be reinstated if Secured Party is ever required to return or restore the payment of all or any portion of the Indebtedness (all as though such payment had
never been made). 
 (g) THIS AGREEMENT AND THE RIGHTS AND OBLIGATIONS OF THE PARTIES HEREUNDER SHALL IN ALL RESPECTS BE
GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF CONNECTICUT (WITHOUT REGARD TO THE CONFLICT OF LAWS PRINCIPLES OF SUCH STATE), INCLUDING ALL MATTERS OF CONSTRUCTION, VALIDITY AND PERFORMANCE, REGARDLESS OF THE
LOCATION OF THE COLLATERAL. 

 IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have
duly executed this Agreement in one or more counterparts, each of which shall be deemed to be an original, as of the day and year first aforesaid. 
  

									
	SECURED PARTY:	 		 	DEBTOR:
			
	General Electric Capital Corporation	 		 	Genpath Therapeutics, Inc.
					
	By:	 	/s/ John Edel	 		 	By:	 	/s/ Peter Courossi
	Name:	 	John Edel	 		 	Name:	 	Peter Courossi
	Title:	 	Senior Vice President	 		 	Title:	 	Acting CFO

 AMENDMENT 
 THIS AMENDMENT is made as of the 23rd day of Dec., 2003, between General Electric Capital Corporation (“Secured Party”) and
GENPATH THERAPEUTICS, INC. (“Debtor”) in connection with that certain Master Security Agreement, dated as of December 8, 2003 (“Agreement”). The terms of this Amendment are hereby incorporated into the Agreement as though
fully set forth therein. Section references below refer to the section numbers of the Agreement. The Agreement is hereby amended as follows: 
  

	2.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 

 Subsection (m) is hereby added to and made a part of the Agreement and reads as follows: 
 “(m) Debtor’s Intellectual Property, as defined in Section 7 below, is and will remain free and clear of all liens, claims and encumbrances of any kind whatsoever, except for Permitted Liens as defined in subsection
(k) of this Section.” 
  

	5.	REPORTS. 

 Subsection (b) is
hereby amended by substituting the following: 
 “(b) Debtor will deliver to Secured Party financial statements as follows. If Debtor is a
privately held company, then Debtor agrees to provide monthly financial statements, certified by Debtor’s president or chief financial officer including a balance sheet, statement of operations and cash flow statement within 30 days of each
month end and its complete audited annual financial statements, certified by a recognized firm of certified public accountants, within 120 days of fiscal year end or at such time as Debtor’s Board of Directors receives the audit. If Debtor is a
publicly held company, then Debtor agrees to provide quarterly unaudited statements and annual audited statements, certified by a recognized firm of certified public accountants, within 10 days after the statements are provided to the Securities and
Exchange Commission (“SEC”). All such statements are to be prepared using generally accepted accounting principles (“GAAP”) and, if Debtor is a publicly held company, are to be in compliance with SEC requirements.”

  

	7.	DEFAULT AND REMEDIES. 

 Subsection
(a) is hereby amended by substituting the following: 
 “(a) Debtor shall be in default under this Agreement and each of the other
Debt Documents if: 
 (i) Debtor breaches its obligation to pay when due any installment or other amount due or coming due under any of the Debt
Documents and fails to cure the breach within ten (10) 
 days; 
 (ii) Debtor, without the prior consent of Secured Party, attempts to or does sell, rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or encumber (except for Permitted
Liens) any of the Collateral; 

 (iii) Debtor breaches any of its material insurance obligations under Section 4; 
 (iv) Debtor materially breaches any of its other material obligations under any of the Debt Documents and fails to cure that breach within thirty
(30) days after written notice from Secured Party; 
 (v) Any warranty, representation or statement made by Debtor in any of the Debt
Documents or otherwise in connection with any of the Indebtedness shall be false or misleading in any material respect; 
 (vi) Any of the
Collateral is subjected to attachment, execution, levy, seizure or confiscation in any legal proceeding or otherwise, or if any legal or administrative proceeding is commenced against Debtor or any of the Collateral, which in the good faith judgment
of Secured Party after notice to the Debtor subjects any of the Collateral to a material risk of attachment, execution, levy, seizure or confiscation and no bond is posted or protective order obtained to negate such risk; 
 (vii) Debtor materially breaches or is in material default under any other agreement between Debtor and Secured Party; 
 (viii) Debtor or any guarantor or other obligor for any of the Indebtedness (collectively “Guarantor”) dissolves, terminates
its existence, becomes insolvent or ceases to do business as a going concern; 
 (ix) If Debtor or any Guarantor is a natural person, Debtor or
any such Guarantor dies or becomes incompetent; 
 (x) A receiver is appointed for all or of any part of the property of Debtor or any
Guarantor, or Debtor or any Guarantor makes any assignment for the benefit of creditors; 
 (xi) Debtor or any Guarantor files a petition under
any bankruptcy, insolvency or similar law, or any such petition is filed against Debtor or any Guarantor and is not dismissed within forty-five (45) days; 
 (xii) Debtor’s improper filing of an amendment or termination statement relating to a filed financing statement describing the Collateral; 
 (xiii) Debtor materially defaults under any other material obligation for (A) borrowed money, (B) the deferred purchase price of property or
(C) payments due under any material lease agreement; 
 (xiv) At any time during the term of this Agreement Debtor sells more than 50% of
its interest in the company to another corporation or business or all or substantially all of its assets without Secured Party’s prior written consent; 
 (xv) There is a material adverse change in the Debtor’s financial condition. “Material Adverse Change” shall be defined as any adverse change in the Debtor’s balance sheet which, in
the sole reasonable judgement of the Secured Party, materially impairs Debtor’s ability to repay the Indebtedness. 

 (xvi) Debtor or any guarantor or other obligor for any of the Indebtedness sells, transfers, assigns,
mortgages, pledges, leases, grants a security interest in or encumbers any or all of Debtor’s Intellectual Property now existing or hereafter acquired. Intellectual Property shall consist of but not be limited to any and all owned or licensed
patents, trademarks and copyrights. For purposes of this paragraph xvi, licenses or sublicenses by the Debtor of its material Intellectual Property as part of a research and development or similar arrangement shall be excluded. Debtor shall provide
Lessor with a listing of licenses and sublicenses granted to third parties within ten (10) days of receipt of written request.” 
 TERMS USED, BUT NOT OTHERWISE DEFINED HEREIN SHALL HAVE THE MEANINGS GIVEN TO THEM IN THE AGREEMENT. EXCEPT AS EXPRESSLY AMENDED HEREBY, THE AGREEMENT SHALL REMAIN IN FULL FORCE AND EFFECT. IF THERE IS
ANY CONFLICT BETWEEN THE PROVISIONS OF THE AGREEMENT AND THIS AMENDMENT, THEN THIS AMENDMENT SHALL CONTROL. 
 IN WITNESS
WHEREOF, the parties hereto have executed this Amendment simultaneously with the Agreement by signature of their respective authorized representative set forth below. 
  

									
	General Electric Capital Corporation	 		 	Genpath Therapeutics, Inc.
					
	By:	 	/s/ John Edel	 		 	By:	 	/s/ Peter Courossi
	Name:	 	John Edel	 		 	Name:	 	Peter Courossi
	Title:	 	SVP	 		 	Title:	 	Acting CFO

 General Electric Capital Corporation 
 AMENDMENT TO 
 MASTER SECURITY AGREEMENT DATED DECEMBER 8, 2003 
 BY AND BETWEEN 
 GENPATH PHARMACEUTICALS, INC., AS DEBTOR 
 AND 
 GENERAL ELECTRIC CAPITAL CORPORATION, AS SECURED PARTY

 Debtor and Secured Party hereby amend Master Security Agreement dated December 8, 2003, all Collateral Schedules thereunder and all
Promissory Notes and other related documents (herein collectively referred to as the “Agreements”) to reflect Debtor’s name change from GENPATH THERAPEUTICS, INC. to GENPATH PHARMACEUTICALS, INC. 
 Debtor and Secured party acknowledge, agree and consent that the Pay Proceeds Letter dated December 18, 2003 associated with the Promissory Note dated
December 23, 2003 is hereby amended as follows: 
  

			
	$162,720.95	  	To: GenPath Pharmaceuticals, Inc.
	$1,398,147.76	  	To: Comerica Bank (loan payoff #3073514778)

 All other terms and conditions of the Agreements remain the same. 
 IN WITNESS WHEREOF, Debtor and Secured Party have each caused this Amendment to be duly executed in their respective names. 
  

									
	 DEBTOR:
 GenPath
Pharmaceuticals, Inc.
	 		 	 SECURED PARTY:
 General Electric Capital Corporation

					
	By:	 	/s/ Peter Courossi	 		 	By:	 	/s/ John Edel
	 Title:
 Date:
	 	 Peter Courossi, Chief Financial Officer
 February 6, 2004
	 		 	 Title:
 Date:
	 	 SVP

 General Electric Capital Corporation 
 AMENDMENT TO MASTER SECURITY AGREEMENT DATED DECEMBER 8, 2003. 
 BY AND BETWEEN 
 GENPATH PHARMACEUTICALS, INC., AS DEBTOR 
 AND 
 GENERAL ELECTRIC CAPITAL CORPORATION, AS SECURED PARTY

 Debtor and Secured Party hereby amend Master Security Agreement dated December 8,2003, all Collateral Schedules thereunder and all
Promissory Notes and other related documents (herein collectively referred to as the “Agreements”) to reflect Debtor’s name change from GenPath Pharmaceuticals, Inc. to AVEO Pharmaceuticals, Inc. 
 All other terms and conditions of the Agreements remain the same. 
 IN WITNESS WHEREOF, Debtor and Secured Party have each caused this Amendment to be duly executed in their respective names. 
  

									
	DEBTOR:	 		 	SECURED PARTY:
			
	 GenPath Pharmaceuticals, Inc.
 fka AVEO Pharmaceuticals, Inc.
	 		 	General Electric Capital Corporation
					
	By:	 	/s/ Peter Courossi	 		 	By:	 	/s/ John Edel
	Title:	 	Chief Financial Officer	 		 	Title:	 	SVP
			
	Date: 7-Mar-2005	 		 	Date: 4-8-05

 AMENDMENT NO. 2 
 THIS AMENDMENT NO. 2 is made as of the 23rd day of March 2006, between General Electric Capital Corporation (“Secured Party”) and
AVEO PHARMACEUTICALS, INC. (“Debtor”) in connection with that certain Master Security Agreement, dated as of December 8, 2003, as amended by Amendment dated as of December 23, 2003 and Name Change Amendment dated March 7,
2005 (the “Agreement”). The terms of this Amendment No. 2 are hereby incorporated into the Agreement as though fully set forth therein. Secured Party and Debtor mutually desire to amend the Agreement as set forth below. Section
references below refer to the section numbers of the Agreement. 
 A. Deletion of existing provisions. 
 2. REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 
 Subsection (m) is hereby deleted in its entirety. 
 7. DEFAULT AND REMEDIES. 
 Subsection (a)(xvi) is hereby deleted in
its entirety. 
 B. Financial Covenants Addendum. Addendum No. 001 (Financial Covenants) is incorporated by
reference and made part of the Agreement. 
 C. Partial Release of Collateral. Upon the execution and
delivery of this Amendment No. 2 and the Financial Covenants Addendum No. 001, (i) the Secured Party hereby releases any and all liens, claims or other security interests in all assets of the Debtor except for the equipment financed
by the Secured Party pursuant to the Agreement under specific Collateral Schedules (the “Financed Assets”), (ii) the Agreement shall be deemed modified and amended such that (X) the security interest granted pursuant to
Section 1 of the Agreement shall be limited to the Financed Assets and (Y) the Additional Collateral Rider shall be terminated and no longer of force or effect and (iii) the Secured Party authorizes the Debtor to file a UCC-3
Amendment. 
 TERMS USED, BUT NOT OTHERWISE DEFINED HEREIN SHALL HAVE THE MEANINGS GIVEN TO THEM IN THE AGREEMENT. EXCEPT AS
EXPRESSLY AMENDED HEREBY, THE AGREEMENT SHALL REMAIN IN FULL FORCE AND EFFECT. IF THERE IS ANY CONFLICT BETWEEN THE PROVISIONS OF THE AGREEMENT AND THIS AMENDMENT NO. 2, THEN THIS AMENDMENT NO. 2 SHALL CONTROL. 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment No. 2
by-signature of their respective authorized representative set forth below. 
  

									
	General Electric Capital Corporation	 		 	Aveo Pharmaceuticals, Inc.
					
	By:	 	/s/ Diane Earle	 		 	By:	 	/s/ Tuan Ha-Ngoc
	Name:	 	Diane Earle	 		 	Name:	 	Tuan Ha-Ngoc
	Title:	 	Duly Authorized Signatory	 		 	Title:	 	President & CEO

 FINANCIAL COVENANTS 
 ADDENDUM NO. 001 
 TO MASTER SECURITY AGREEMENT 

 DATED AS OF DECEMBER 8, 2003 
 THIS ADDENDUM NO. 001 (this “Addendum No. 001”) made as of the 23rd day of March, 2006, amends and supplements the above referenced agreement (the
“Agreement”), between General Electric Capital Corporation (together with its successors and assigns, if any, “Secured Party”) and Aveo Pharmaceuticals, Inc. (“Debtor”) and is hereby
incorporated into the Agreement as though fully set forth therein. Capitalized terms not otherwise defined herein shall have the meanings set forth in the Agreement. 
 The Agreement is hereby amended by adding the following: 
 FINANCIAL
COVENANTS. 
 (a) Debtor shall, at all times during the term of the Agreement, comply with the following: 
 Maintain minimum Unrestricted Cash (as defined below) equal to the greater of $12,000,000.00 or 9 months of Monthly Cash Burn (as defined
below). 
 Unrestricted Cash shall be defined as cash on hand plus investments in marketable securities with maturities of less
than thirty-six (36) months, less such cash pledged to other parties and any contingent liability associated with similar cash covenants under leases, loans or other financial arrangements. 
 Monthly Cash Burn shall be defined as the sum of net income plus non-cash charges plus the change in deferred revenue for the most recent 6
months ended divided by 6, minus current portions of long-term debt divided by 12. Long-term debt shall include indebtedness for borrowed money. 
 If this covenant is violated it shall not be an event of default provided Debtor provides Secured Party within ten (10) days of such occurrence an irrevocable non-declining Letter of Credit or cash
Security Deposit (which shall be held pursuant to the terms of the agreement attached as Exhibit A) in the amount of 70% of the total outstanding balance of Secured Party’s loan as of the date of the violation; provided that any such Letter of
Credit or Security Deposit shall be returned or released and the Letter of Credit be terminated if the Debtor thereafter provides financial statements that demonstrate that Debtor has an amount of Unrestricted Cash equal to 18 months of Monthly Cash
Burn. In no event, will the Letter of Credit or Security Deposit held be greater than the outstanding balance of the Secured Party’s loan. 

 (b) COMPLIANCE REPORTS. Debtor’s Authorized Representative shall certify
periodically that Debtor is in compliance with the requirements of subsection (a) above. Such notification and certification shall be provided within thirty (30) days after the end of each fiscal quarter (the “Compliance
Date”), reflecting such information as of the end of such fiscal quarter. If Debtor fails timely to provide such notification and compliance certificates, within fifteen (15) days after the Compliance Date, such failure shall be deemed
a default under the Agreement if not cured within two (2) business days after written notice from Secured Party. The reports required under this section are in addition to and not a substitute for the reports required under the REPORTS Section
of the Agreement. 
 Except as expressly modified hereby, all terms and provisions of the Agreement shall remain in full force and effect. This
Addendum No. 001 is not binding or effective with respect to the Agreement until executed on behalf of Secured Party and Debtor by authorized representatives of Secured Party and Debtor. 
 IN WITNESS WHEREOF, Debtor and Secured Party have caused this Addendum No. 001 to be executed by their duly authorized representatives as of the
date first above written. 
  

									
	Secured Party:	 		 	Debtor:
					
	By:	 	/s/ Diane Earle	 		 	By:	 	/s/ Tuan Ha-Ngoc
	Name: 	 	Diane Earle	 		 	Name: 	 	Tuan Ha-Ngoc
	Title:	 	Duly Authorized Signatory	 		 	Title:	 	President & CEO
				
	Attest:	 		 		 	
					
	By:	 	 	 		 		 	
					
	Name:

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