Document:

<PAGE>
                                                                Exhibit 10.11

                               BIOMEDICINES, INC.
                           909 Marina Village Parkway
                            Alameda, California 94501

August 14, 1997

S. Mark Moran, M.D.
55 Orinda View Road
Orinda, CA 94563

Re: Employment Agreement

Dear Mark:

         BioMedicines, Inc. proposes to enter into the following employment
agreement ("Agreement") with you.

         I have incorporated the terms we have discussed regarding your
employment into this agreement and the proposed terms and conditions are set
forth below. If the terms of the Agreement are satisfactory, please indicate
your acceptance of the Agreement by executing this letter and returning it to
me.

         1. DEFINITIONS. The terms defined in this section shall have the
meanings set forth below for purposes of this Agreement.

            a. "Board of Directors" shall mean the Board of BioMedicines, Inc.

            b. "BioMedicines" or "Company" shall mean BioMedicines, Inc.

            c. "Employee" shall refer to you, S. Mark Moran, M.D.

            d. "Without Cause" shall mean that the Company has without "Cause,"
as defined below, and without the Employee's written consent:

               (1)  terminated the Employee's services with the Company;

               (2)  materially reduced the Employee's duties, responsibilities
                    and status with the Company;

               (3)  reduced the Employee's base salary by more than five percent
                    (except pursuant to Company mandated pay cuts or pay
                    reductions which are uniformly applied to the Company's
                    management, if and only if the Company employs at least
                    three (3) senior managers at that time (in such event,
                    "Management")); or

               (4)  materially reduced the benefits provided to Employee;

<PAGE>

               (5)  required that the Employee be based at a location more than
                    30 miles from Orinda, California.

            e. "Cause" shall mean one of the following:

               (1)  Employee's repeated failure or refusal to perform his duties
                    and responsibilities set forth herein;

               (2)  conviction of any felony or crime involving moral turpitude,
                    fraud or misrepresentation;

               (3)  any willful or intentional act having the effect of
                    substantially and materially injuring the reputation,
                    business or business relationships of the Company; and

               (4)  any material breach of any of the provisions of this
                    Agreement if such breach is not cured within 10 days after
                    written notice thereof to Employee.

            f. "Change of Control" solely for purposes of this Agreement shall
mean any transaction or series of related transactions in which (i)
substantially all of the assets of the Company are sold; or (ii) any merger,
reorganization or acquisition in which the stockholders of the Company
immediately prior to such transaction or series of related transactions hold
less than 50.1% of the equity securities of the surviving entity (or any parent
thereof) immediately after such transaction.

         2. DUTIES AND OBLIGATIONS.

            a. The Employee shall serve as the Company's President and Chief
Executive Officer, which title was approved by unanimous written consent of the
Company's Board of Directors (the "Board") on August 13, 1997. Employee's duties
shall include overseeing all corporate functions and directing the organization
to ensure the attainment of the goals and objectives set forth from time to time
by the Board of Directors.

            b. Employee agrees to abide by the terms and conditions of the
Company's standard Proprietary Information and Inventions Agreement between
Employee and the Company. Employee further agrees that at all times both during
his employment by the Company and after his Termination (hereinafter as defined
in Section 6(a)), he will keep in confidence and trust, and will not use or
disclose, except as directed by the Company, any confidential or proprietary
information of the Company.

            c. Employee represents that he has not entered into, and agrees not
to enter into, any agreement in conflict with the terms of this Agreement or his
employment with the Company.

                                       2.

<PAGE>

         3. DEVOTION OF TIME TO THE COMPANY'S BUSINESS.

            a. Employee shall devote substantially all of his business time,
attention, knowledge, skills and interests to the business of the Company and
the Company shall be appropriately entitled to the benefits and profits arising
from such work or services of Employee.

            b. During the term of this Agreement, Employee shall not, directly
or indirectly, engage or participate in any business that is in competition with
the business of the Company. The parties acknowledge that the purchase and/or
sale by Employee of securities of any public or private company shall not
constitute a violation of this covenant.

         4. COMPENSATION AND BENEFITS.

            a. BASE COMPENSATION. Beginning August 1, 1997, the Company shall
pay to Employee an annual salary of two hundred thousand dollars ($200,000),
less all applicable withholdings, prorated for any partial employment period and
payable in equal monthly installments in accordance with the Company's payroll
schedule. The Compensation Committee of the Board shall annually review the
then-current level of Employee's salary to determine the amount, if any, of
salary change, provided that the foregoing shall not serve to exempt Employee
from any Company-mandated pay cuts or pay reductions which are uniformly applied
to the Company's Management (as defined above). Any pay increase or pay cut will
be effective as of the effective time determined by the Board and the Board
shall advise Employee of such adjustment, if any.

            b. BONUS. The Employee will be eligible to receive a cash bonus in
addition to the Employee's Current base salary. The Compensation Committee of
the Board shall annually review the contributions of the Employee to the Company
and determine the appropriate bonus, if any, to which the Employee shall be
entitled.

            c. BENEFITS. At the time of this Agreement or for such time as
otherwise provided in this Agreement, Employee shall be entitled to family
health insurance and short- and long-term disability insurance and shall also be
entitled to participate in benefits in the Company's benefit program as in
effect from time to time, which may include (without limitation): dental
insurance, group term life insurance, vacation pay, sick pay and 401(k) plan.
Employee will accrue vacation time during the term of this Agreement at a rate
equal to three weeks per annum. The vacation may be taken at times agreed upon
by Employee and the Company, and unused vacation for any annual period shall
carry over to the next two (2) subsequent years until used, but shall not carry
over more than two (2) years. During that vacation, Employee will receive
Employee's usual compensation.

            d. STOCK OPTIONS. Upon entering this Agreement, the Employee shall
be granted and receive non-qualified stock options (the "Options") to purchase
an aggregate of Five Hundred Thousand (500,000) shares of the Company's Common
Stock (as adjusted for any stock splits, stock dividends, combinations,
recapitalizations and the like with respect to the outstanding shares of capital
stock of the Company), which Options shall have an exercise price of $0.10 per
share. The Options shall expire on August 13, 2005. The Options shall vest in
six tranches upon the achievement of certain milestones as set forth in the
Vesting Schedule

                                       3.

<PAGE>

contained in clauses (i)-(vi) below. Any Options which vest on or after August
13, 2001 shall be immediately exercisable at the time of vesting. With respect
to milestones achieved, and Options which vest, prior to August 13, 2001, only a
certain portion of the number of the Options indicated in the vesting schedule
to be so vested upon the achievement of such milestone shall be immediately
exercisable, as follows: upon the achievement prior to August 13, 2001 of any of
the milestones set forth below (the date of each such achievement is referred to
herein as a "Pre-2001 Achievement Date"), the percentage ("P") of the Options
which are indicated to be so vested upon such milestone achievement which shall
be immediately exercisable on the Pre-2001 Achievement Date shall be determined
in accordance with the following formula:

                         P = 20 + ((Months Passed) * 80)
                         -------------------------------
                                       48

For purposes of this formula, "Months Passed" means the number of full monthly
periods which have elapsed between August 1, 1997 and the Pre-2001 Achievement
Date.

         The balance of the Options which have vested but which have not yet
become immediately exercisable shall become immediately exercisable in monthly
pro-rata installments, commencing 30 days following the Pre-2001 Achievement
Date and ending on August 13, 2001 until the Employee's termination of
employment with the Company for any reason or no reason. Upon such termination,
all options which are not vested and have not become immediately exercisable
pursuant to the terms hereof (whether pursuant to this paragraph or the last
paragraph of this Section 5) shall terminate in their entirety, subject to the
acceleration provisions of Section 8(a) hereof.

                    VESTING SCHEDULE

               (i)  Options shall vest as to 20,000 shares upon the execution
                    and delivery by the Company (or any corporate partner of the
                    Company) of a definitive licensing agreement covering any
                    product developed by the Company or any corporate partner of
                    the Company (a "Product"), irregardless of whether such
                    agreement is made with a United States party;

              (ii)  Options shall vest as to 20,000 shares upon FDA approval of
                    IND with respect to any Product;

             (iii)  Options shall vest as to 50,000 shares upon the successful
                    completion of a Phase I study conducted in the United States
                    with respect to any Product;

              (iv)  Options shall vest as to 125,000 shares upon the successful
                    completion of a Phase II study conducted in the United
                    States with respect to any Product;

               (v)  Options shall vest as to 150,000 shares upon the successful
                    completion of a Phase III study conducted in the United
                    States with respect to any Product; and

                                       4.

<PAGE>

              (vi)  Options shall vest as to 135,000 shares upon the successful
                    completion of NDA approval of any Product.

         The share numbers contained in the vesting schedule set forth above
shall be appropriately adjusted in the event of any stock splits, stock
dividends, combinations, recapitalizations and the like with respect to the
outstanding shares of capital stock of the Company.

         As used in clauses (iii)-(vi) of the Vesting Schedule, the term
"successful" shall mean the achievement of clinical results with respect to a
Product such that the Board of Directors approves a plan for a Product to move
into the next phase level of clinical testing for the indication in the United
States. Upon the in-licensing of any Product, Options shall vest in proportion
to the stage of development of the Product at the time of inlicensing in
accordance with the above vesting schedule.

         In the event that any of the milestones set forth above (other than the
execution of a licensing agreement reflected in (i) above) shall be achieved
outside of the United States, the vesting schedule set forth above with respect
to each milestone shall apply with following modification (and subject to the
exercisability principles set forth in the introduction to the vesting
schedule): 60% of the number of Options allocated for vesting upon the
achievement of the relevant milestone shall vest upon such achievement. In the
event the corresponding milestone is subsequently achieved in the United States,
the remaining 40% of such Options shall vest at that time.

         In the event of the death of Employee or a Change in Control, all
vested Options which have not yet become immediately exercisable pursuant to the
formula above shall become immediately exercisable and shall remain exercisable
for a period of twelve (12) months thereafter. In addition, in the event of the
Termination (as defined in Section 8) of Employee Without Cause, the
exercisability of vested options shall accelerate as provided in Section 8.

         5. REIMBURSEMENT OF EXPENSES. As of the date hereof, and during the
term of this Agreement, the Company realizes that the Employee, in performing
Employee's duties hereunder, may be required to spend sums of money in
connection with those duties on behalf of or for the benefit of the Company
including, without limitation, in connection with the establishment of a home
office. Employee may present to the Company, on a weekly basis, an itemized
voucher listing all sums of money reasonably paid or expenses reasonably
incurred by Employee in the performance of Employee's duties on behalf of or for
the benefit of the Company, and on presentation of that itemized voucher and
appropriate receipts for such expenses the Company will reimburse Employee or
pay the expense incurred in conformity with the Company policy for all such
reasonable expenses including, but not limited to, a home office,
telecommunications, travel, meals, lodging, entertainment and promotion. The
Company agrees and acknowledges that Employee shall be reimbursed for up to
$38,000 of expenses incurred by Employee on behalf of and for the benefit of the
Company prior to the date of this Agreement, which expenses have been paid by
Employee.

                                       5.

<PAGE>

         6. PURCHASE OPTION.

            a. The parties acknowledge that the Employee is the owner of
1,000,000 shares of the common stock of the Company (the "Stock"). The Employee
agrees that, in the event the Employee ceases to be continuously employed by the
Company, or a parent or subsidiary of the Company, for any reason, with or
Without Cause, the Company shall have an option (the "Purchase Option") to
repurchase from the Employee up to 80% of the shares of Stock now owned by the
Employee (800,000 shares), as more fully described below. The number of shares
of Stock subject to the Purchase Option shall decrease from month to month
during the term of this Agreement as set forth below in subsection (b) of this
Section 6. For the purposes of this Section 6, Employee's "continuous
employment" shall cease when Employee ceases to be actively employed by the
Company or a parent or subsidiary of the Company. A leave of absence (regardless
of the reason therefor) shall be deemed to constitute the cessation of
Employee's active employment unless such leave is authorized by the Company in
writing and Employee returns to work within the time specified in such
authorization or in any amendment thereto. The date when continuous employment
ceases is hereinafter referred to as the Termination Date.

            b. For so long as the Employee remains continuously employed by the
Company, and subject to the provisions of Section 8 herein, the Purchase Option
shall lapse and no longer be exercisable in monthly allotments, as equal in
amount as is possible, over a period of forty-eight (48) months. Accordingly,
for so long as the Employee remains continuously employed by the Company and
subject to the provisions of Section 8 herein, (i) the Purchase Option shall
lapse and no longer be exercisable as to 16,667 shares of Stock (as adjusted for
any stock splits, combinations, recapitalizations and the like with respect to
the outstanding shares of capital stock of the Company) on the first day of each
month commencing September 1, 1997 and continuing thereafter through August 1,
2001, and (ii) the Purchase Option shall lapse and no longer be exercisable as
to the final 16,651 shares of Stock (as adjusted for any stock splits,
combinations, recapitalizations and the like with respect to the outstanding
shares of capital stock of the Company) subject to the Purchase Option on
September 1, 2001. The death of the Employee and a Change in Control shall be
deemed to constitute events resulting in the cessation of continuous employment
of the Employee for purposes of this Section 6. In the event of the death of the
Employee or a Change in Control prior to any other Termination Date, the
Purchase Option shall lapse and no longer be exercisable as to 50% of the shares
of Stock which remain subject to the Purchase Option as of the date of
Employee's death or the Change in Control, as the case may be; PROVIDED,
HOWEVER, upon a Change in Control, in the event that the Employee is not offered
a position to remain with the Company (or the successor thereto) at a level of
responsibility (with respect to the business conducted by the Company) and
compensation that is equivalent to or greater than the level of responsibility
and compensation of Employee with the Company immediately prior to the Change in
Control, the Purchase Option shall fully lapse and shall no longer be
exercisable as to the remainder of the shares of Stock which remain subject to
the Purchase Option as of the date of the Change in Control.

            c. The Purchase Option, if exercised by the Company, shall be
exercised by written notice signed by an officer of the Company and delivered to
Employee within sixty (60) days of the Termination Date. The purchase price for
the shares of Stock which are subject to the Purchase Option, which shall be
specified in the written notice of the Company to Employee,

                                       6.

<PAGE>

shall be the original purchase price for such shares of Stock; provided,
however, that the Purchase Option shall continue for a period of up to one year
from the Termination Date to the extent that the Company reasonably determines
that such an extension of time is necessary to prevent the repurchase of
Employee's shares of Stock from causing other capital stock of the Company to
not qualify as "small business stock" under Section 1202 of the Internal Revenue
Code of 1986, as amended.

            d. In the event the Company does not deliver written notice of its
election to exercise the Purchase Option within sixty (60) days following the
Termination Date or such one (1) year period provided above, the Company shall
be deemed to have declined to exercise the Purchase Option and the Purchase
Option shall expire as to all shares of Stock subject to the Purchase Option as
of the Termination Date.

            e. Subject to the terms of this Section 6, Employee shall have all
the rights of a stockholder with respect to the shares of Stock which are
subject to the Purchase Option, including without limitation the right to vote
the shares of Stock and receive any cash dividends declared thereon.

            f. In the event of any stock splits, combinations, recapitalizations
and the like with respect to the outstanding shares of capital stock of the
Company, the number of shares subject to the Purchase Option and the purchase
price shall be accordingly adjusted. In addition, if at any time or from time to
time, there is (i) a dividend of any security, stock split or other change in
the character or amount of any of the outstanding securities of the Company, or
(ii) any consolidation, merger or sale of all, or substantially all, of the
assets of the Company, 80% of any and all new, substituted or additional
securities or other property (the "New Securities") to which Employee is
entitled by reason of his ownership of the Stock shall be subject to the
Purchase Option; provided, however, in accordance with the "lapse of repurchase
rights" principles and schedule provided for in subsection (b) above, (i) a
pro-rata portion of such New Securities shall not become subject to the Purchase
Option based on the proportion which the number of shares of Stock with respect
to which the Purchase Option has already lapsed bears to the number of New
Securities distributed, and (ii) repurchase rights with respect to any such New
Securities shall lapse on a pro-rata basis in accordance with the principles and
schedule set forth in subsection (b) above.

            g. The Employee agrees and acknowledges that certificates
representing up to 800,000 shares of Stock of the Company owned by the Employee
which are subject to the provisions of this Section 6 shall have endorsed
thereon the following legend:

         "THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO THE
         TERMS AND CONDITIONS OF A CERTAIN EMPLOYMENT AGREEMENT WHICH INCLUDES
         THE RIGHT OF THE CORPORATION TO REPURCHASE THESE SECURITIES. COPIES OF
         THE AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF
         THE CORPORATION."

                                       7.

<PAGE>

         7. ELIGIBILITY FOR SEVERANCE BENEFITS.

            a. GENERAL RULE. Except as otherwise provided in this Agreement,
should the employment of the Employee be terminated Without Cause, the Employee
shall be entitled to the severance benefits as set forth in Section 8.

            b. DEATH OR DISABILITY. If the Employee dies after he has ceased to
be an Employee but prior to receiving full payment of his severance benefits as
provided in Section 8(a)(1), (2) or (3), if any, the portion of the severance
benefits that remains to be paid shall be paid to the surviving spouse of the
Employee, or, if there is no surviving spouse, to the Employee's estate.

         8. TERMINATION OF EMPLOYMENT.

            a. The Company may terminate Employee's employment under this
Agreement at any time, for any reason, with or Without Cause by giving written
notice of its intent to terminate the employment (a "Termination"). Upon
Termination Without Cause, the Employee shall be entitled to the following
severance benefits:

               (i)  Should the Employee be terminated Without Cause prior to
                    August 13, 1998, the Company will thereafter pay to Employee
                    six (6) months' base salary and the Company shall continue
                    to provide to Employee all benefits which Employee is
                    receiving prior to such termination for a period of six (6)
                    months after such termination. In addition, upon the
                    Termination of Employee Without Cause prior to August 13,
                    1998, (x) the number of vested Options which are at such
                    time immediately exercisable shall be increased to the
                    aggregate number of vested Options which would be
                    immediately exercisable six (6) months following the date of
                    such Termination Without Cause and (y) the number of shares
                    of Stock as to which the Purchase Option shall have lapsed
                    as of the date of such Termination Without Cause shall be
                    increased to the aggregate number of shares of Stock as to
                    which the Purchase Option would otherwise have lapsed as of
                    the first day of the month subsequent to the date which is
                    six (6) months following the date of such Termination
                    Without Cause (the number of vested Options shall include
                    Options that, had Employee not been terminated, would
                    otherwise have vested on the Company's achievement during
                    such six (6) -month period [or after such six (6) -month
                    period if the Company shall have unreasonably from a
                    corporate business perspective or in bad faith delayed such
                    achievement until after the end of such six (6) -month
                    period] of any milestone(s) (as described in Section 4) in
                    which Employee substantially participated prior to his
                    termination; subject to the preceding clause, the number of
                    shares of Stock as to which the Purchase Option shall lapse
                    and the number of vested Options that are

                                       8.

<PAGE>

                    exercisable shall be based solely upon the passage of time
                    through the end of such six (6) -month period).

               (ii) Should the Employee be terminated Without Cause after August
                    13, 1998 and prior to August 13, 1999, the Company will
                    thereafter pay to Employee nine (9) months base salary and
                    the Company shall continue to provide to Employee all
                    benefits which Employee is receiving prior to such
                    termination for a period of nine (9) months after such
                    termination. In addition, upon the Termination of Employee
                    Without Cause after August 13, 1998 and prior to August 13,
                    1999, (x) the number of vested Options which are at such
                    time immediately exercisable shall be increased to the
                    aggregate number of vested Options which would be
                    immediately exercisable nine (9) months following the date
                    of such Termination Without Cause and (y) the number of
                    shares of Stock as to which the Purchase Option shall have
                    lapsed as of the date of such Termination Without Cause
                    shall be increased to the aggregate number of shares of
                    Stock as to which the Purchase Option would otherwise have
                    lapsed as of the first day of the month subsequent to the
                    date which is nine (9) months following the date of such
                    Termination Without Cause (the number of vested Options
                    shall include Options that, had Employee not been
                    terminated, would otherwise have vested on the Company's
                    achievement during such nine (9) -month period [or after
                    such nine (9) -month period if the Company shall have
                    unreasonably from a corporate business perspective or in bad
                    faith delayed such achievement until after the end of such
                    nine (9) -month period] of any milestone(s) (as described in
                    Section 4) in which Employee substantially participated
                    prior to his termination; subject to the preceding clause,
                    the number of shares of Stock as to which the Purchase
                    Option shall lapse and the number of vested Options that are
                    exercisable shall be based solely upon the passage of time
                    through the end of such nine (9) -month period).

              (iii) Should the Employee be terminated Without Cause at any time
                    after August 13, 1999, the Company will thereafter pay to
                    Employee twelve (12) months base salary and the Company
                    shall continue to provide to Employee all benefits which
                    Employee is receiving prior to such termination for a period
                    of twelve (12) months after such termination. In addition,
                    upon the Termination of Employee Without Cause at any time
                    after August 13, 1999, (x) the number of vested Options
                    which are at such time immediately exercisable shall be
                    increased to the aggregate number of vested Options which
                    would be immediately exercisable twelve (12) months
                    following the date of such Termination Without Cause and (y)
                    the number of shares of Stock as to which the Purchase
                    Option shall have lapsed as of the date of such Termination
                    Without Cause

                                       9.

<PAGE>

                    shall be increased to the aggregate number of shares of
                    Stock as to which the Purchase Option would otherwise have
                    lapsed as of the first day of the month subsequent to the
                    date which is twelve (12) months following the date of such
                    Termination Without Cause (the number of vested Options
                    shall include Options that, had Employee not been
                    terminated, would otherwise have vested on the Company's
                    achievement during such twelve (12) -month period [or after
                    such twelve (12) -month period if the Company shall have
                    unreasonably from a corporate business perspective or in bad
                    faith delayed such achievement until after the end of such
                    twelve (12) -month period] of any milestone(s) (as described
                    in Section 4) in which Employee substantially participated
                    prior to his termination; subject to the preceding clause,
                    the number of shares of Stock as to which the Purchase
                    Option shall lapse and the number of vested Options that are
                    exercisable shall be based solely upon the passage of time
                    through the end of such twelve (12) -month period).

            b. The Employee shall not be entitled to receive severance benefits
during any period in which he remains an employee of the Company. The Employee
may elect to have his severance benefits paid in one of the following ways:

               (i)  A single lump sum distribution paid upon, or as soon as
                    reasonably practicable after the Termination of his
                    employment; or

              (ii)  A deferred lump sum distribution paid in January of the year
                    following the year his employment terminates; or

             (iii)  Two installments, which do not have to be of equal amounts,
                    with the first paid upon, or as soon as reasonably
                    practicable after, the Termination of his employment and the
                    second paid in January of the year following the year his
                    employment terminates.

         Election of one of the above methods is accomplished by providing
written notice to the Company of such election within fifteen calendar days of
the Employee's Termination. If no election is made within that period, the
severance benefits will automatically be paid pursuant to Section 8(b)(i).
Without regard to the payment method elected, no interest shall accrue or be
paid with respect to the amount of the Employee's severance benefits.

         Except for any payments for earned salary, accrued but unused and
unexpired vacation, 401(k) Plan distributions, and the above mentioned severance
benefits, if applicable, neither party will be obligated to pay the other any
payment as a result of, or in connection with, the Termination of Employee's
employment with the Company (including but not limited to any salary or benefits
following the date of Termination).

         Notwithstanding any other provision of this Section 8, with regard to
severance payments in respect of salary, the Company shall not be obligated to
pay Employee more than one-half

                                      10.

<PAGE>

(1/2) of such amount in a lump sum upon, or as soon as reasonably practicable
after the Termination of his employment and the remainder shall be paid in equal
pro rata monthly installments over the applicable six (6), nine (9) or twelve
(12) month severance period.

         9. MISCELLANEOUS.

            a. GOVERNING LAW. This Agreement shall be interpreted, construed,
governed and enforced according to the laws of the State of California.

            b. ARBITRATION. Any dispute or claim arising out of or in connection
with this Agreement will be finally settled by binding arbitration in any of the
following California counties -Santa Clara, San Mateo, San Francisco, Alameda or
Contra Costa - and in accordance with the rules of the American Arbitration
Association, by one (1) arbitrator appointed in accordance with such rules. The
arbitrator shall apply California law, without reference to rules of conflicts
of law or rules of statutory arbitration, to the resolution of any dispute.
Judgment on the award rendered by the arbitrator may be entered in any court
having jurisdiction thereof. Notwithstanding the foregoing, the parties may
apply to any court of competent jurisdiction for preliminary or interim
equitable relief or to compel arbitration in accordance with this paragraph,
without breach of this arbitration provision.

            c. ATTORNEYS' FEES. In the event of any controversy, claim or
dispute between the parties, arising out of or relating to this Agreement or the
breach hereof, or the interpretation hereof, each party shall bear its own legal
fees and expenses. Notwithstanding the foregoing, in the event of a finding by
any properly appointed arbitrator or a court having jurisdiction over such
matter that any party initiating an action under this Agreement failed to have a
reasonable prospect of prevailing on its claim, the arbitrator or court shall
have discretion to award the prevailing party attorneys' fees and costs incurred
by it with respect to such claim or action. The "prevailing party" means the
party determined by the court to have most nearly prevailed, even if such party
did not prevail in all matters, not necessarily the one in whose favor a
judgment is rendered.

            d. AMENDMENTS. No amendment or modification of the terms or
conditions of this Agreement shall be valid unless in writing and signed by the
parties hereto.

            e. SEVERABILITY. All agreements and covenants contained herein are
severable, and in the event any of the above shall be held to be invalid or
unenforceable, this Agreement shall be interpreted as if such invalid agreements
or covenants were not contained herein.

            f. SUCCESSORS AND ASSIGNS. The rights and obligations of the Company
under this Agreement shall inure to the benefit of and shall be binding upon the
successors and assigns of the Company. The Employee shall not be entitled to
assign any of his rights or obligations under this Agreement.

            g. ENTIRE AGREEMENT. This Agreement, along with any other Agreements
set forth herein, including without limitation, the Proprietary Information and
Inventions Agreement, constitutes the entire agreement between the parties with
respect to the employment of Employee.

                                      11.

<PAGE>

         If you have any questions, please do not hesitate to call me at (650)
854-7691.

                               Very truly yours,

                               BIOMEDICINES, INC.

                               By:
                                  ------------------------------------
                                  Chairman of the Board of Directors

AGREED TO AND ACCEPTED BY:

--------------------------------
S. Mark Moran, M.D.
Employee

                                      12.<PAGE>
                                                                Exhibit 10.12

November 23, 1999

S. Mark Moran, M.D.
55 Orinda View Road
Orinda, CA  94563

RE:      EMPLOYMENT AGREEMENT

Dear Mark:

This letter will serve to memorialize certain actions taken pursuant to, and
modifications of, that certain Employment Agreement dated August 14, 1997,
between you and BioMedicines, Inc. (the "Employment Agreement"). The capitalized
terms used herein have the meanings given to them in the Employment Agreement.

         1. Salary/Bonus. Employee's current annual base salary, effective as of
January 1, 1999, is $240,000. Employee will be considered for a bonus of up to
$25,000 in December of 1999. The actual timing and amount of any bonus shall be
at the discretion of the Board of Directors.

         2. Stock Purchase. The Company hereby agrees to sell to you 500,000
shares of Common Stock, which are in addition to the 1,500,000 shares currently
owned by you, at a price of $0.225 per share pursuant to the terms and
conditions contained in the stock purchase agreement hereto as Exhibit A.

         3. Interest Forgiveness. In connection with the promissory note in the
principal amount of $50,000 given by you in connection with your early exercise
Stock Purchase Agreement dated November 23, 1998, the Company agrees to forgive
interest accrued under such note, through November 23, 1999. The Company further
agrees to give due consideration to a similar forgiveness of interest at the
time of your 2000 review and in subsequent years for so long as such note
remains outstanding. It is our understanding that there will be no tax liability
to you associated with said interest forgiveness. However, in the event this
understanding proves to be incorrect, the Company agrees to make additional
payments to you as necessary to hold you harmless from any such liability on an
after tax basis.

         4. Principal Forgiveness on a Public Offering or Change of Control. In
the event of an initial public offering of the Company's stock or in the event
of a Change of Control, the Company agrees that, if you remain as an employee of
the Company up to the date on which such offering or Change of Control takes
place, the Company will forgive the unpaid principal balance of all loans made
by the Company to you in connection with the purchase of Company Stock and, in
addition, make a "tax gross up" payment to you equal to 94% of the principal
amount so forgiven.

<PAGE>

         5. No Other Effect. Except as expressly provided for herein, the terms
and conditions of the Employment Agreement, including without limitation the
obligation of the Company to continue to provide support for your home office on
the same basis as it is currently provided, are not intended to be modified by
this letter agreement and shall remain in full force and effect.

Very truly yours,

BioMedicines, Inc.

By: /s/ Brian G. Atwood
   -------------------------------------------
         Chairman of the Board of Directors

AGREED TO AND ACCEPTED BY:

/s/ S. Mark Moran, M.D.
----------------------------------------------
S. Mark Moran, M.D.
Employee

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00016-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00016-of-00352.parquet"}]]