Document:

EX-10.2

 Exhibit 10.2 
 SECOND AMENDMENT TO AMENDED AND RESTATED DEVELOPMENT 
 AND MANUFACTURING
AGREEMENT 
 THIS SECOND AMENDMENT TO AMENDED AND RESTATED DEVELOPMENT AND MANUFACTURING AGREEMENT (“Second
Amendment”) is made and entered into this 27th day of February, 2013 (“Second Amendment Effective Date”) by and between BAXTER HEALTHCARE CORPORATION, a Delaware corporation (“Baxter”), and
CORNERSTONE THERAPEUTICS, a Delaware corporation (“Cornerstone”). 
 WHEREAS, Baxter and
Cornerstone are parties to an Amended and Restated Development and Manufacturing Agreement dated November 6, 2009 as first amended on July 12, 2010 (collectively, the “Original Agreement”); 

AND WHEREAS, Baxter and Cornerstone wish to amend certain provision(s) of the Original Agreement; 

NOW, THEREFORE, in consideration of the foregoing recitals and the mutual promises hereinafter set forth Baxter and Cornerstone
agree that the following amendment(s) shall be made to the Original Agreement, effective as of the Second Amendment Effective Date: 
 1. Section 6.4.1 shall be deleted in its entirety and replaced with the following: 
 “Annual Purchase Obligation. Cornerstone agrees to purchase from Baxter a minimum number of units of Product in each calendar year during the Term of this Agreement (the
“Annual Purchase Obligation”), which Annual Purchase Obligation shall be pro-rated for any partial calendar year. The Annual Purchase Obligation is set forth in Exhibit E. In the event Cornerstone orders and purchases
less than the Annual Purchase Obligation in any calendar year (the “Shortfall”), Cornerstone shall pay to Baxter [***] the [***] and the [***] of the [***] based on the following: 

 

	 	(a)	For the Shortfall in 2012, Cornerstone shall pay Baxter an amount equivalent to [***]; 

 

	 	(b)	If there is a Shortfall for 2013 or any remaining calendar year in the Initial Term or any Renewal Term, Cornerstone shall pay Baxter an amount equivalent to
[***].” 

 2. Sections 6.4.1.1, 6.4.1.2, 6.4.1.3 and 6.4.1.4 shall be deleted in their entirety and
intentionally left blank. 
  

[***] Confidential portions of the exhibit have been omitted and filed separately with the Securities and Exchange Commission. 

 3. In Section 7.1, the second, third and fourth sentences shall be deleted. 

4. In Section 7.2, the following new phrase shall be added at the beginning of the existing sentence: 

“Commencing in [***],” 
 5. Section 7.5 shall be deleted in its entirety and replaced with the following: 
 “Commencing with [***] the price per bag shall be increased to reflect an additional charge (“Surcharge”) of $[***] per bag. Baxter will provide no less than [***] written notice to
Cornerstone prior to the implementation of the Surcharge. The Surcharge of $[***] per bag will apply to all firm purchase orders submitted by Cornerstone to Baxter no less than [***] after receipt of notice in [***]. Commencing on [***], the
Surcharge per bag will be [***]; therefore, all firm purchase orders submitted by Cornerstone to Baxter in [***] shall reflect a Surcharge of $[***] per bag. Commencing on [***],[***] Surcharge will apply for [***] or for any calendar year in the
remainder of the Initial Term or any Renewal Term. Further, in the event of a Shortfall in [***] or [***], the Surcharge per bag shall apply to any Shortfall amount for that year.” 

6. In Section 17.1, “December 31, 2016” is hereby deleted in its entirety and replaced with the following: 

“December 31, 2019” 
 7. Section 17.1.1 and its subparts, 17.1.1.1, 17.1.1.2 and 17.1.1.3, shall be deleted in their entirety and intentionally left blank. 

8. Section 17.2.1.4 is hereby deleted in its entirety and intentionally left blank. 

9. Exhibit E shall be deleted in its entirety and replaced with the new Exhibit E attached to this Second Amendment. 

10. The phrase “this Agreement” as it appears in the Original Agreement or this Second Amendment shall be deemed to refer to
the Original Agreement, as modified by this Second Amendment. 
 11. Except as modified by this Second Amendment, the terms of
the Original Agreement shall continue in full force and effect. 
  
 [***] Confidential portions of the exhibit have been omitted and filed separately with the Securities and Exchange Commission. 

  
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 12. This Second Amendment may be executed in counterparts and all of such counterparts taken
together shall be deemed one and the same instrument. Any photocopy, facsimile, or pdf of the executed Second Amendment shall constitute an original. 
 IN WITNESS WHEREOF, the parties have caused this Second Amendment to be executed by their duly authorized representatives. 

 

									
	BAXTER HEALTHCARE CORPORATION	 		 	CORNERSTONE THERAPEUTICS
					
	By:	 	 /s/ Robert Felicelli
	 		 	By:	 	 /s/ Craig A. Collard

	Name:	 	 Robert Felicelli
	 		 	Name:	 	 Craig A. Collard

	Title:	 	 Global Franchise Head
	 		 	Title:	 	 CEO

  
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 EXHIBIT E 
 MANUFACTURING FEES AND ANNUAL PURCHASE OBLIGATION 
 Cornerstone will fulfill the Annual
Purchase Obligation by purchasing agreed upon batches from any of the four Cardene Presentations (1X RTU Saline, 1X RTU Dextrose, 2X RTU Saline, or 2X RTU Dextrose). 
 The Annual Purchase Obligation & pricing tiers per each unit of Product are set forth below: 
  

																	
	 	 	2013	 	2014	 	2015
Tiers**	 	2015	 	2016	 	2017	 	2018	 	2019
	 Price For First [***]
	 	*[***]	 	*$[***]	 	First [***]	 	$[***]	 	**$[***]	 	***See
note below.	 	***See
note below.	 	***See
note below.
	 >[***] Tier
	 	*$[***]	 	*[***]	 	>[***]Tier	 	$[***]	 	**$[***]	 	***See
note below.	 	***See
note below.	 	***See
note below.
	 Annual Purchase Obligation (000)
	 	[***]	 	[***]	 		 	[***]	 	[***]	 	[***]	 	[***]	 	[***]

 Notes: 
  

	*	The Manufacturing Fee per unit of Product shall also be subject to a Surcharge per Section 7.5. 

	**	Annual price adjustments shall commence in [***] in accordance with Section 7.2. 

	***	The Manufacturing Fee per unit of Product shall be based on the [***], and shall be subject to an annual price adjustment for the current year in accordance
with Section 7.2. 

  
 [***] Confidential portions of the exhibit have been omitted and filed separately with the Securities and Exchange Commission. 

  
 4EX-10.3

 Exhibit 10.3 
 CORNERSTONE THERAPEUTICS INC. 
 Restricted Stock Agreement

 Name of Recipient: 
 Number of shares of restricted common stock awarded: 
 Grant Date: 

Cornerstone Therapeutics Inc. (the “Company”) has selected you to receive the restricted stock award described above, which is
subject to the provisions of the Company’s 2004 Stock Incentive Plan (the “Plan”), and the terms and conditions contained in this Restricted Stock Agreement (the “Agreement”). Please confirm your acceptance of this
restricted stock award and of the terms and conditions of this Agreement by signing a copy of this Agreement where indicated below. 
  

			
	CORNERSTONE THERAPEUTICS INC.
		
	By:	 	  

	Name:	 	
	Title:	 	

  

	
	Accepted and Agreed:
	
	  

	[Name of Recipient]

  
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 CORNERSTONE THERAPEUTICS INC. 

Restricted Stock Agreement 
 The terms and conditions of the award of shares of restricted common stock of the Company (the “Restricted Shares”) made to the Recipient, as set forth on the cover page of this Agreement, are
as follows: 
  

	 	1.	Issuance of Restricted Shares. 

 (a) The Restricted Shares are issued to the Recipient, effective as of the Grant Date (as set forth on the cover page of this Agreement), in consideration of employment services rendered and to be
rendered by the Recipient to the Company. 
 (b) As promptly as practicable following the Grant Date, the
Company shall issue one or more certificates in the name of the Recipient for the Restricted Shares. Such certificate(s) shall initially be held on behalf of the Recipient by the [Secretary/Treasurer]1 of the Company. Following the vesting of any Restricted Shares
pursuant to Section 2 below, the [Secretary/Treasurer] shall, if requested by the Recipient, deliver to the Recipient a certificate representing the vested Restricted Shares. 

(c) In lieu of the procedure in Section 1(b), at the Company’s option, the Restricted Shares may be transferred electronically
by the Treasurer of the Company to the Company’s transfer agent to hold as custodian on behalf of Recipient in the transfer agent’s restricted stock ledger. Following the vesting of any Restricted Shares pursuant to Section 2 below,
the Treasurer shall notify the transfer agent to transfer such vested shares from its restricted stock ledger to its general stock ledger. 
 (d) The Recipient agrees that the Restricted Shares shall be subject to the forfeiture provisions set forth in Section 3 of this Agreement and the restrictions on transfer set forth in Section 4
of this Agreement. 
  

	 	2.	Vesting. 

 (a) Vesting
Schedule. Unless otherwise provided in this Agreement or the Plan, the restrictions covering the Restricted Shares shall lapse, and the Restricted Shares shall vest, in four equal installments on each of the first four (4) anniversaries of
the Grant Date. 
 (b) Acceleration of Vesting. Unless otherwise provided under the terms of any employment agreement
between the Recipient and the Company (any such agreement, as amended, restated or superseded, the “Employment Agreement”), any acceleration of vesting with respect to the Restricted Shares shall be subject to the vesting provisions in the
Plan. In the event of any conflict between the Plan and the Employment Agreement, the provisions of the Employment Agreement shall control. 

 

	1 	 Officer specified generally should be the Secretary except that the Treasurer should be specified for restricted stock awards to the Secretary.

  
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	 	3.	Forfeiture of Unvested Restricted Shares Upon Employment Termination. 

 In the event that the Recipient ceases to be employed by the Company for any reason or no reason, with or without cause, except as provided in Section 2(b) above, all of the Restricted Shares that
are unvested as of the time of such employment termination shall be forfeited immediately and automatically to the Company, without the payment of any consideration to the Recipient, effective as of such termination of employment. The Recipient
hereby authorizes the Company to take any actions necessary or appropriate to cancel any certificate(s) representing forfeited Restricted Shares and transfer ownership of such forfeited Restricted Shares to the Company; and if the Company or its
transfer agent requires an executed stock power or similar confirmatory instrument in connection with such cancellation and transfer, the Recipient shall promptly execute and deliver the same to the Company. The Recipient shall have no further
rights with respect to any Restricted Shares that are so forfeited. If the Recipient is employed by a subsidiary of the Company, any references in this Agreement to employment with the Company shall instead be deemed to refer to employment with such
subsidiary. 
  

	 	4.	Transfer of Restricted Shares. 

 (a) Restrictions on Transfer. The Recipient shall not sell, assign, transfer, pledge, hypothecate or otherwise dispose of, by operation of law or otherwise (collectively “transfer”) any
Restricted Shares, or any interest therein, until such Restricted Shares have vested, except that the Recipient may transfer such Restricted Shares: (a) to or for the benefit of any spouse, children, parents, uncles, aunts, siblings,
grandchildren and any other relatives approved by the Board (as defined below) (collectively, “Approved Relatives”) or to a trust established solely for the benefit of the Recipient and/or Approved Relatives, provided that such
Restricted Shares shall remain subject to this Agreement (including without limitation the forfeiture provisions set forth in Section 3 and the restrictions on transfer set forth in this Section 4) and such permitted transferee shall, as a
condition to such transfer, deliver to the Company a written instrument confirming that such transferee shall be bound by all of the terms and conditions of this Agreement; or (b) as part of the sale of all or substantially all of the shares of
capital stock of the Company (including pursuant to a merger or consolidation). The Company shall not be required (i) to transfer on its books any of the Restricted Shares which have been transferred in violation of any of the provisions of
this Agreement or (ii) to treat as owner of such Restricted Shares or to pay dividends to any transferee to whom such Restricted Shares have been transferred in violation of any of the provisions of this Agreement. 

(b) Buy-Out Transaction. If there is a “Buy Out Transaction,” which for purposes of this Agreement shall mean
(i) any transaction or series of transactions is consummated whereby Chiesi Farmaceutici S.p.A. or any of its affiliates (collectively, “Chiesi”) acquires all or substantially all of the outstanding capital stock of the Company
(regardless of whether such transaction or series of transactions constitutes a Business Combination) or (ii) a Business Combination that would constitute a Change in Control Event and that the Board, or the Compensation Committee thereof,
determines in its discretion will be treated for purposes of this Agreement as a Buy Out Transaction and so notifies the Recipient, then any Restricted Shares 

  
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that remain unvested at the time of the consummation of the Buy-Out Transaction (either because such shares were not vested immediately prior to consummation of the transaction or because the
vesting of such shares was not accelerated in connection with consummation of the transaction) shall, at the time the Buy-Out Transaction is consummated, be converted into a right to receive an amount equal to the consideration otherwise payable in
respect of such Restricted Shares in the Buy-Out Transaction, including any right to receive additional consideration based on future contingencies, with respect to such number of shares (the “Restricted Cash”), which amount shall
be retained and paid out by the acquirer to the Recipient in accordance with the vesting provisions described in paragraph 2 above; provided, however, if the Recipient’s employment is involuntarily terminated by the Company (or
any successor entity) other than for Cause or if the Recipient’s employment is constructively terminated as a result of the Recipient’s compensation, authority, duties, or responsibilities being materially reduced, or as a result of a
material change in the Recipient’s location of employment, then all Restricted Cash not previously paid to the Recipient shall be paid to the Recipient in a lump sum within ten (10) calendar days following the date of termination.

  

	 	5.	Restrictive Legends. 

 All
certificates representing Restricted Shares shall have affixed thereto a legend in substantially the following form, in addition to any other legends that may be required under applicable law: 

“These shares of stock are subject to forfeiture provisions and restrictions on transfer set forth in a certain Restricted Stock
Agreement between Cornerstone Therapeutics Inc. (the “Corporation”) and the registered owner of these shares (or his or her predecessor in interest), and such Agreement is available for inspection without charge at the office of the
Secretary of the Corporation.” 
  

	 	6.	Rights as a Shareholder. 

 Except as otherwise provided in this Agreement, for so long as the Recipient is the registered owner of the Restricted Shares, the Recipient shall have all rights as a shareholder with respect to the
Restricted Shares, whether vested or unvested, including, without limitation, any rights to vote the Restricted Shares and act in respect of the Restricted Shares at any meeting of shareholders and to receive dividends and distributions with respect
to such Restricted Shares; provided, however, that if any such dividends or distributions are paid in shares, or consist of a dividend or distribution to holders of Common Stock other than an ordinary cash dividend, the shares, cash or other
property will be subject to the same restrictions on transferability and forfeitability as the shares of Restricted Stock with respect to which they were paid. Each dividend payment will be made no later than the end of the calendar year in which
the dividends are paid to shareholders of that class of stock or, if later, the 15th day of the third month following the date the dividends are paid to shareholders of that class of stock. 

  
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	 	7.	Provisions of the Plan. 

This Agreement is subject to the provisions of the Plan, a copy of which is furnished to the Recipient with this Agreement. 

 

	 	8.	Tax Matters. 

 (a)
Acknowledgments; Section 83(b) Election. The Recipient acknowledges that he or she is responsible obtaining the advice of the Recipient’s own tax advisors with respect to the acquisition of the Restricted Shares and the Recipient is
relying solely on such advisors and not on any statements or representations of the Company or any of its agents with respect to the tax consequences relating to the Restricted Shares. The Recipient understands that the Recipient (and not the
Company) shall be responsible for the Recipient’s tax liability that may arise in connection with the acquisition, vesting and/or disposition of the Restricted Shares. The Recipient acknowledges that he or she has been informed of the
availability of making an election under Section 83(b) of the Internal Revenue Code, as amended, with respect to the issuance of the Restricted Shares and that the Recipient has decided not to file a Section 83(b) election. 

(b) Withholding. The Recipient acknowledges and agrees that the Company has the right to deduct from payments of any kind
otherwise due to the Recipient any federal, state, local or other taxes of any kind required by law to be withheld with respect to the vesting of the Restricted Shares. On each date on which Restricted Shares vest, the Company shall deliver written
notice to the Recipient of the amount of withholding taxes due with respect to the vesting of the Restricted Shares that vest on such date; provided, however, that the total tax withholding cannot exceed the Company’s minimum statutory
withholding obligations (based on minimum statutory withholding rates for federal and state tax purposes, including payroll taxes, that are applicable to such supplemental taxable income). The Recipient shall satisfy such tax withholding obligations
by making a cash payment to the Company on the date of vesting of the Restricted Shares, in the amount of the Company’s withholding obligation in connection with the vesting of such Restricted Shares. The Recipient may, if the Board, in its
sole discretion, so approves in writing in advance of the applicable vesting date, satisfy such tax withholding obligations by transferring to the Company, on each date on which Restricted Shares vest under this Agreement, such number of Restricted
Shares that vest on such date as have a fair market value (calculated using the last reported sale price of the common stock of the Company on the NASDAQ Capital Market on the trading date immediately prior to such vesting date) equal to the amount
of the Company’s tax withholding obligation in connection with the vesting of such Restricted Shares. In the event that the Board approves such method of satisfying the tax withholding, to effect such delivery of Restricted Shares, the
Recipient shall be required to authorize the Company to take any actions necessary or appropriate to cancel any certificate(s) representing such Restricted Shares and transfer ownership of such Restricted Shares to the Company; and if the Company or
its transfer agent requires an executed stock power or similar confirmatory instrument in connection with such cancellation and transfer, the Recipient shall promptly execute and deliver the same to the Company. 

  
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	 	9.	Miscellaneous. 

 (a)
Authority of the Board. In making any decisions or taking any actions with respect to the matters covered by this Agreement, the Board of Directors of the Company or a designated committee of the Board, including, but not limited to, the
Compensation Committee of the Board (collectively, the “Board”) shall have all of the authority and discretion, and shall be subject to all of the protections, provided for in the Plan. All decisions and actions by the Board with respect
to this Agreement shall be made in the Board’s discretion and shall be final and binding on the Recipient. 
 (b) No
Right to Continued Employment. The Recipient acknowledges and agrees that, notwithstanding the fact that the vesting of the Restricted Shares is contingent upon his or her continued employment by the Company, this Agreement does not constitute
an express or implied promise of continued employment or confer upon the Recipient any rights with respect to continued employment by the Company. 
 (c) Governing Law. This Agreement shall be construed, interpreted and enforced in accordance with the internal laws of the State of Delaware without regard to any applicable conflicts of laws
provisions. 
 (d) Recipient’s Acknowledgments. The Recipient acknowledges that he or she has read this Agreement,
has received and read the Plan, and understands the terms and conditions of this Agreement and the Plan. 
 (e) Defined
Terms. Capitalized terms not defined in this Agreement shall have the meaning ascribed to them in the Employment Agreement or the Plan. If any such term is defined both in the Employment Agreement and the Plan, the definition of such term
included in the Employment Agreement shall control. 
 (f) Section 409A. Notwithstanding anything to the contrary in
this Agreement, if the Recipient is a “specified employee” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (“Section 409A”) at the time of the Recipient’s termination (other than due
to death), then the lump sum cash payment of Restricted Cash, if any, to be paid pursuant to Section 4(b) of this Agreement, together with any other severance payments or separation benefits that are considered deferred compensation under
Section 409A (collectively, the “Deferred Compensation Separation Benefits”), that are payable within the first six (6) months following the Recipient’s termination of employment will become payable on the first regular
payroll date that occurs on or after the date six (6) months and one (1) day following the date of the Recipient’s termination of employment. All subsequent Deferred Compensation Separation Benefits, if any, will be payable in
accordance with the payment schedule applicable to each payment or benefit. Notwithstanding anything herein to the contrary, if the Recipient dies following the Recipient’s termination but prior to the six (6) month anniversary of the
Recipient’s termination, then any payments delayed in accordance with this subsection will be payable in a lump sum as soon as administratively practicable after the date of the Recipient’s death and all other Deferred Compensation
Separation Benefits will be payable in accordance with the payment schedule applicable to each payment or benefit. Each payment and benefit 

  
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payable under this Agreement is intended to constitute separate payments for purposes of Section 1.409A-2(b)(2) of the Treasury Regulations. Furthermore, any amount paid under this Agreement
that satisfies the requirements of the “short-term deferral” rule set forth in Section 1.409A-1(b)(4) of the Treasury Regulations shall not constitute Deferred Compensation Separation Benefits for purposes of this subsection.

  
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