Document:

EX-10.10

 Exhibit 10.10 

Execution Copy 
 FOIA CONFIDENTIAL
TREATMENT REQUESTED 
 Confidential Materials omitted and filed separate with the Securities and Exchange Commission 

Triple asterisks denote omissions 

LICENSE AGREEMENT 
 by and
between 
 KINEX PHARMACEUTICALS, LLC 

and 
 PHARMAESSENTIA CORP

 8 December, 2011 
  

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 

FOIA CONFIDENTIAL TREATMENT REQUESTED 

Confidential Materials omitted and filed separate with the Securities and Exchange Commission 

Triple asterisks denote omissions 

TABLE OF CONTENTS 
  

					
	 	  	Page	 
	 ARTICLE 1 DEFINITIONS
	  	 	2	  
		
	 ARTICLE 2 GRANT OF RIGHTS
	  	 	13	  
		
	 ARTICLE 3 INFORMATION TRANSFER; DEVELOPMENT AND COMMERCIALIZATION; REGULATORY MATTERS
	  	 	14	  
		
	 ARTICLE 4 PAYMENTS AND STATEMENTS
	  	 	23	  
		
	 ARTICLE 5 REPRESENTATIONS AND WARRANTIES
	  	 	29	  
		
	 ARTICLE 6 PATENT MATTERS
	  	 	32	  
		
	 ARTICLE 7 CONFIDENTIALITY AND PUBLICITY
	  	 	41	  
		
	 ARTICLE 8 TERM AND TERMINATION
	  	 	45	  
		
	 ARTICLE 9 INDEMNIFICATION AND INSURANCE
	  	 	49	  
		
	 ARTICLE 10 MISCELLANEOUS
	  	 	53	  

  

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 THIS LICENSE AGREEMENT (this “Agreement”) is made as of 8th December, 2011
(“Effective Date”), by and between KINEX PHARMACEUTICALS, LLC, a limited liability company organized and existing under the laws of the State of New York and having its principal office at 701 Ellicott Street, Buffalo, New York
14203, USA (“Kinex”) and PHARMAESSENTIA CORP, a privately-held company existing under the laws of the Taiwan and having its principal office at 13F, No. 3 YuanQu Street, Nankang District, Taipei 115, TAIWAN
(“PharmaEssentia”). 
 B A C K G R O U N D: 

Kinex owns or Controls the Kinex Intellectual Property of KX01 (also known as KX2-391) and KX02 (also
known as KX2-361) and is developing the Compounds for oncology and other indications; 
 PharmaEssentia and its Affiliates have experience
in the development, marketing, promotion and sale of topical pharmaceutical products for dermatology conditions predominately in Asia; and PharmaEssentia desires to obtain the exclusive right and license in the Territory to further develop and
thereafter commercialize a Licensed Product for indications in the Field (as such capitalized terms are hereinafter defined); and Kinex desires to grant to PharmaEssentia such exclusive right and license in the Territory, all on the terms and
conditions set forth below. 

  

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 NOW, THEREFORE, in consideration of the mutual representations, warranties and covenants
herein contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 

ARTICLE 1 
 DEFINITIONS

 Unless specifically set forth to the contrary herein, the following terms, whether used in the singular or plural, shall have the
respective meanings set forth below: 
 1.1 “Act” means the United States Food, Drug, and Cosmetic Act of 1938, as amended,
and the rules and regulations promulgated thereunder, or any successor act, as the same shall be in effect from time to time. 
 1.2
“Affiliate” means with respect to a Party (a) any corporation or business entity of which more than fifty percent (50%) of the securities or other ownership interests representing the equity, the voting stock or general
partnership interest are owned, controlled or held, directly or indirectly, by a Party; (b) any corporation or business entity which, directly or indirectly, owns, controls or holds more than fifty percent (50%) (or the maximum ownership
interest permitted by law) of the securities or other ownership interests representing the equity, voting stock or general partnership interest of a Party; (c) any corporation or business entity of which, directly or indirectly, an entity
described in the immediately preceding subsection (b) controls or holds more than fifty percent (50%) (or the maximum ownership interest permitted by law) of the securities or other ownership interests representing the equity, voting stock
or general partnership interest of such corporation or entity; or (d) any corporation or business entity of which a Party has the right to acquire, directly or indirectly, more than fifty percent (50%) of the securities or other ownership
interests representing the equity, voting stock or general partnership interest thereof. 
 1.3 “Agreement Term” has the
meaning set forth in Section 8.1(a). 
 1.4 “Breaching Party” has the meaning set forth in Section 8.2(b). 

  
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 1.5 “Business Day” means any calendar day, except that if an activity to be
performed or an event to occur falls on a Saturday, Sunday or a day which is recognized as a national holiday in the place of performance of an applicable activity or occurrence of an applicable event, then the activity may be performed or the event
may occur on the next day that is not a Saturday, Sunday or nationally recognized holiday. 
 1.6 “Calendar Quarter” means
for each Calendar Year, each of the three (3) month periods ending on March 31, June 30, September 30 and December 31; provided, however, that the first Calendar Quarter of any period specified under this
Agreement shall extend from the commencement of such period to the end of the first complete Calendar Quarter thereafter; and the last Calendar Quarter shall end upon the expiration or termination of this Agreement. 

1.7 “Calendar Year” means, for the first Calendar Year, the period commencing on the Effective Date and ending on
December 31, 2011, and for each year thereafter, each successive period beginning on January 1 and ending twelve (12) consecutive calendar months later on December 31. 

1.8 “CFR” means the United States Code of Federal Regulations. 

1.9 “cGMP” means current good manufacturing practices. 

1.10 “Claims” has the meaning set forth in Section 9.2. 

1.11 “Clinical Studies” means any clinical studies of a Licensed Product conducted on humans. 

1.12 “Commercialize” or “Commercialization” means promotion, marketing, sale, supply, manufacture, import,
export and distribution of Licensed Products, including any educational or pre-launch activities. 

  
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 1.13 “Commercially Reasonable Efforts” means exerting such efforts and
employing such resources as would normally be exerted or employed by a Party for its other drug candidates and pharmaceutical products of a comparable stage of development and commercial potential; and for this Agreement, with respect to Regulatory
Approval and First Commercial Sale of Licensed Product, means completion of a proof of concept study by December 31, 2013, commencement of a Phase III Clinical Study by September 30, 2015, filing an application for Regulatory Approval in
either Taiwan or Mainland China by December 31, 2016, and achieving First Commercial Sale of Licensed Product in each country in the Territory within 60 days of the Regulatory Approval in such country in the Territory; provided, however,
Kinex shall grant a six month extension on the foregoing timelines at the reasonable request of PharmaEssentia. 
 1.14
“Completion” means, with respect to any Clinical Study, the completion of treatment for the necessary number of patients required by the applicable protocol and completion of the statistical analysis of the study data. 

1.15 “Compound(s)” means singly and collectively the Src/tubulin inhibitors, KX-01 (also known as KX2-391) and KX-02 (also
known as KX2- 361), both as diagrammed on Schedule 1.1 attached hereto, and any pharmaceutically acceptable salts, hydrates, solvates, amides, prodrugs and esters of the foregoing, or mixtures thereof. 

1.16 “Control” means possession of the ability to grant the rights and licenses as provided for herein without violating the
terms of any agreement or arrangement with any Third Party. 
 1.17 “Copyright” means the right granted to an author or
creator of an original work fixed in any tangible medium of expression, including without limitation, books, literary works, computer programs, and pictorial, graphic, dramatic and sculptured works, as well as derivative works and translations. 

  
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 1.18 “Data” means any and all research data, pharmacology data, preclinical
data, clinical data, chemistry, manufacturing and control (“CMC”) data and/or all other similar documentation necessary or useful for the Development or Commercialization of the Compounds or Licensed Products. 

1.19 “Develop” or “Development” means those activities undertaken with respect to the Compounds or Licensed
Products which are devoted to the progression of a potential pharmaceutical product in Clinical Studies and any other activities directed toward quality issues, publication, Regulatory Approval, formulation, production or CMC of the Compounds or
Licensed Products, including any other pre-launch activities. 
 1.20 “Disputed Claim” has the meaning set forth in
Section 9.4(b). 
 1.21 “Dollar” or “$” means the lawful currency of the United States. 

1.22 “Drug Approval Application” means an application for Regulatory Approval of a Licensed Product as a pharmaceutical
product in a regulatory jurisdiction. 
 1.23 “Effective Date” has the meaning set forth in the Preamble hereof. 

1.24 “Field” means psoriasis and other non-malignant skin conditions. 

1.25 “First Commercial Sale” means, with respect to any Licensed Product, the first sale to a Third Party for end use or
consumption of such Licensed Product in a country in the Territory by PharmaEssentia, its Affiliates or sublicensees after receipt of Regulatory Approval in such country or, where Regulatory Approval is not required, then the first sale for end use
or consumption of a Licensed Product to a Third Party in that country in the Territory in connection with the nationwide introduction of such Licensed Product in that country in the Territory by PharmaEssentia, its Affiliates or sublicensees. 

  
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 1.26 “Generic Competition” shall be deemed to exist for a specific Licensed
Product in a particular country as of any date if, during the two (2) immediately preceding Calendar Years, (a) Generic Products have a market share in the applicable country of at least thirty percent (30%) of the then combined unit
volume of the applicable Licensed Product and Generic Products, or (b) at least one Generic Product is commercially introduced in such country and the Net Sales by PharmaEssentia of the applicable Licensed Product in the applicable country
decrease by at least thirty percent (30%) with each of (a) and (b) measured as an average taken over such two (2) Calendar Years and compared to the Calendar Year immediately preceding the beginning of such two (2) Calendar
Year period. 
 1.27 “Generic Product” means any pharmaceutical product that is (i) sold by a Third Party that is not
a licensee or Sublicensee of PharmaEssentia or its Affiliates or sublicensees, under a marketing authorization granted by a Regulatory Authority to such Third Party, (ii) contains one of the Compounds as an active pharmaceutical ingredient, and
(iii) is approved in reliance on the prior approval of a Licensed Product as determined by the applicable Regulatory Authority in the applicable country. 

1.28 “IFRS” means International Financial Reporting Standards as adopted by the International Accounting Standard Board,
consistently applied. 
 1.29 “Improvements” means all inventions and Know-How, patentable or otherwise, made, created,
developed, conceived or reduced to practice by or on behalf of a Party and/or any of its Affiliates pursuant to activities relating to or contemplated by this Agreement during the Agreement Term, that are necessary or useful for the Development or
Commercialization of the Compounds or Licensed Product for use in the Field including developments in the manufacture, formulation, ingredients, preparation, presentation, means of delivery or administration, dosage, indication, methods of use or
packaging and/or sale of the Compounds or Licensed Product. 

  
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 1.30 “IND” means an Investigational New Drug application, this carries the
same meaning in each of the countries in the Territory similar to what is described in the United States in 21 C.F.R. Section 312.23, obtained for purposes of conducting Clinical Studies in accordance with the requirements of the Act and the
regulations promulgated thereunder, including all supplements and amendments thereto relating to the use of the Compounds or Licensed Product in the Field. 

1.31 “Insurance” has the meaning set forth in Section 9.6(a). 

1.32 “Intellectual Property” means Patent Rights, Know-How, Copyrights and Trademarks collectively, that are necessary or
useful for the Development or Commercialization of the Compounds or Licensee Products, including any Improvements thereto. 
 1.33
“Kinex Indemnified Parties” has the meaning set forth in Section 9.1. 
 1.34 “Kinex Intellectual
Property” means the Kinex Patent Rights, Kinex Know-How and other Intellectual Property owned or Controlled by Kinex or any of its Affiliates. 

1.35 “Kinex Know-How” means all Know-How that are owned or Controlled by Kinex or any of its Affiliates. 

1.36 “Kinex Patent Rights” means all Patent Rights that are owned or Controlled by Kinex or any of its Affiliates, including
the Patent Rights listed in Schedule 1.2 and as provided in Section 6.1. 
 1.37 “Know-How” means all proprietary
information and technology, including trade secret information, developments, discoveries, methods, techniques, formulations, Data, and other information, whether or not patentable, that are necessary or useful for the Development or
Commercialization of the Compounds or Licensed Product, or any Improvement thereto, in the Field. 

  
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 1.38 “Law(s)” means all laws, statutes, rules, regulations, ordinances and
other pronouncements having the binding effect of law of any governmental authority. 
 1.39 “Licensed Product(s)” means
any topical product(s) (creams, lotions, sprays, etc.) that contain at least one of the Compounds as an active pharmaceutical ingredient for use in the Territory. 

1.40 “Losses” means any and all damages, awards, deficiencies, settlement amounts, defaults, assessments, fines, dues,
penalties (including penalties imposed by any governmental authority), costs, fees, liabilities, obligations, taxes, liens, losses, lost profits and expenses (including court costs, interest and reasonable fees of attorneys, accountants and other
experts) awarded or otherwise paid or payable to Third Parties. 
 1.41 “NDA” means a new drug application in any of the
countries in the Territory similar to the NDA submitted to the FDA to obtain approval for the marketing of a Licensed Product in the United States, together with all subsequent submissions, supplements and amendments thereto. 

1.42 “Net Sales” means the gross sales amount of Licensed Products invoiced to Third Parties by PharmaEssentia, its
Affiliates and sublicensees, less the following deductions (to the extent included in such gross sales amount): 
 (a) quantity and/or cash
discounts therefor; 
 (b) customs, duties, sales and similar taxes; 

(c) amounts allowed or credited by reason of rejections, return of goods (including as a result of recalls, market withdrawals and other
corrective actions), and retroactive price reductions or allowances specifically identifiable as relating to a Licensed Product including allowances and credits related to inventory management or similar agreements with wholesalers; 

  
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 (d) amounts incurred resulting from government (or any agency thereof) mandated rebate
programs in the Territory; 
 (e) Third Party rebates, patient discount programs, administrative fees and chargebacks or similar price
concessions related to the sale of a Licensed Product; 
 (f) bad debt actually included on PharmaEssentia’s financial statements,
provided that PharmaEssentia has made Commercially Reasonable Efforts to collect on such debts; 
 (g) the expenses for insurance, freight,
packing, shipping and transportation; 
 (h) commissions paid to agents or distributors to secure tender offers or other purchases by local
authorities; and 
 (i) as agreed by the Parties, such agreement not to be unreasonably withheld, any other specifically identifiable
amounts included in a Licensed Product’s gross sales amount that were or ultimately will be credited and that are similar to those listed above, all in accordance with IFRS. 

All such discounts, allowances, credits, rebates and other deductions shall be fairly and equitably allocated to the Licensed Product, and, to the extent
applicable, other products or services of PharmaEssentia or its Affiliates such that the Licensed Products do not bear a disproportionate portion of such deductions. For the avoidance of doubt, Net Sales shall not include sales by PharmaEssentia to
its Affiliates or sublicensees for resale; provided that, if PharmaEssentia sells a Licensed Product to an Affiliate or sublicensee for resale, then the Net Sales calculation shall based on the higher of (i) the amount invoiced
PharmaEssentia to such Affiliate or sublicensee or 

  
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(ii) the amount invoiced by such Affiliate or sublicensee to the Third Parties on the resale of such Licensed Product. For purposes of this Agreement, “sale” shall not include
transfers or other distributions or dispositions of a Licensed Product, at r10 charge, for regulatory purposes, clinical trials, samples, free products or in connection with patient assistance programs or other charitable purposes or to physicians
or hospitals for promotional purposes. A Licensed Product shall be considered “sold” only when billed or invoiced. 
 1.43
“Ongoing Clinical Studies” means Clinical Studies with enrolled patients that are in the process of being conducted. For the avoidance of doubt, this does not include Clinical Studies where no patient dosing has occurred. 

1.44 “Party” means Kinex or PhannaEssentia, as the context may require. 

1.45 “Parties’ Patent Rights” has the meaning set forth in Section 6.3(a). 

1.46 “Patent Rights” means any patents, patent applications, certificates of invention, or applications for certificates of
invention and any supplemental protection certificates, together with any extensions, registrations, confirmations, reissues, substitutions, divisions, continuations or continuations-in-part, reexaminations or renewals thereof that claim or cover
either of the Compounds, Licensed Product or any Improvement, including methods of development, manufacture, formulation, preparation, presentation, means of delivery or administration, dosage, packaging, sale or use thereof. 

1.47 “PharmaEssentia Indemnified Parties” has the meaning set forth in Section 9.1. 

1.48 “PharmaEssentia Know-How” means all Know-How that are owned or Controlled by PharmaEssentia as of the Effective Date and
during the Agreement Term. 

  
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 1.49 “PharmaEssentia Patent Rights” means all Patent Rights that are owned
or Controlled by PharmaEssentia as of the Effective Date and during the Agreement Term, including as provided in Section 6.1. 
 1.50
“Phase I Clinical Study(ies)” means a Clinical Study that is intended to initially evaluate the safety or pharmacological effect of a Licensed Product in the Field in subjects or that would otherwise satisfy requirements of 21 CFR
312.2(a), or its foreign equivalent. 
 1.51 “Phase II Clinical Study(ies)” means a Clinical Study that is intended to
initially evaluate the effectiveness of a Licensed Product in the Field in subjects or that would otherwise satisfy requirements of 21 CFR 312.21(b), or its foreign equivalent. 

1.52 “Phase III Clinical Study(ies)” means a pivotal Clinical Study, the results of which could be used to establish safety
and efficacy of a Licensed Product in the Field as a basis for Regulatory Approval or that would otherwise satisfy requirements of 21 CFR 312.21(c), or its foreign equivalent. 

1.53 “Prime Rate” means the rate announced from time to time by HSBC Bank, N.A. as its “prime rate” in New York,
New York USA which is the base rate upon which other rates charged at such bank are based, and is the best rate available to premium customers at such bank. 

1.54 “Product Label(ing)” shall have the same meaning as defined in the Act and as interpreted by the Regulatory Authority in
each country in the Territory. 
 1.55 “Proprietary Information” means any and all scientific, clinical, technological,
regulatory, marketing, financial and commercial information or data, whether communicated in writing, orally or by any other means, which is owned and under the protection of one Party and is provided by that Party to the other Party in connection
with this Agreement, and shall include Kinex Know-How and PharmaEssentia Know-How, as applicable, and the Data. 

  
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 1.56 “Regulatory Approval” means approval by the relevant Regulatory
Authority of an NDA or other Drug Approval Application, health registration, common technical document, regulatory submission, notice of compliance and any other license or permit required to be approved for the supply, manufacture, use, storage,
distribution, import, export, transport, promotion, marketing and sale of a Licensed Product in a country, region or other regulatory jurisdiction. 

1.57 “Regulatory Authority” means any governmental authority in a country, region or other regulatory jurisdiction that
regulates the supply, manufacture, use, storage, distribution, import, export, transport, promotion, marketing and sale of a Licensed Product. 

1.58 “SEC” means the United States Securities and Exchange Commission and any successor agency having substantially the same
functions. 
 1.59 “Substantial Level Generic Competition” shall be deemed to exist for a Licensed Product in a particular
country as of any date if, during the two (2) immediately preceding Calendar Years, (a) Generic Products have a market share in the applicable country of at least sixty percent (60%) of the then combined unit volume of the applicable
Licensed Product and Generic Products, or (b) at least one Generic Product is commercially introduced in such country and Net Sales of the applicable Licensed Product by PharmaEssentia in the applicable country decrease by at least sixty
percent (60%) with each of (a) and (b) measured as an average taken over such two (2) Calendar Years and compared to the Calendar Year immediately preceding the beginning of such two (2) Calendar Year period. 

1.60 “Territory” means the following designated countries only: Greater China (including Mainland China, Taiwan, Macau, and
Hong Kong), Singapore and Malaysia. All other countries are expressly excluded and retained by Kinex. 

  
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 1.61 “Third Party(ies)” means a person or entity who or which is neither a
Party nor an Affiliate of a Party. 
 1.62 “Trademark” means the trademark(s) for which either Party has sought
registration and all related service marks, domain names and other trademark related rights that are necessary or useful for the Development or Commercialization of the Licensed Products in the Field. 

1.63 “Valid Claim” means any claim in an active patent application or issued in an unexpired patent which has not been held
unenforceable, unpatentable or invalid by a decision of a court or other governmental agency of competent jurisdiction following exhaustion of all possible appeal processes, and which has not been admitted to be invalid or unenforceable through
reissue, reexamination or disclaimer and has not been terminated for failure to pay maintenance fees. 
 ARTICLE 2 

GRANT OF RIGHTS 
 2.1
Grants by Kinex. Subject to the terms and conditions of this Agreement, Kinex hereby grants to PhammEssentia an exclusive right and license throughout the Territory (and with the right to grant sublicenses, with the prior written permission
of Kinex which consent may not be unreasonably withheld) in and to the Kinex Intellectual Property, to develop, label, package, import, export, promote, distribute, make, use, sell, offer for sale, register, commercialize and otherwise exploit the
Licensed Product(s) in the Field and a non-exclusive right to manufacture the Compounds in the Territory but solely for use in the Licensed Products; provided, however, that, notwithstanding the exclusive rights granted to
PharmaEssentia hereunder, Kinex shall retain the right to use the Kinex Intellectual Property in the Territory other than for the promotion, distribution, sale, offer for sale, registration, or commercialization

  
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of Licensed Product(s) in the Field. Any Affiliates of PharmaEssentia exercising any rights of PharmaEssentia under this Agreement shall be located within the Territory; provided, however, that
PharmaEssentia may use Affiliates or Third Parties located outside the Territory to assist in the development of Licensed Products with the prior written consent of Kinex. With respect to sales to Third Party distributors or other parties purchasing
Licensed Product for resale, PharmaEssentia shall use Commercially Reasonable Efforts to restrict such resales to within the Territory, including termination of sales to such parties if required by Kinex. 

2.2 Retained Rights; No Implied Licenses. All rights not specifically granted to PharmaEssentia under this Agreement are reserved and
retained by Kinex. Nothing in this Agreement shall be deemed to constitute the grant of any license or other right to PharmaEssentia, to or in respect of any product, patent, trademark, Proprietary Information, trade secret or other data or any
other Intellectual Property of the other Party, except as set forth under this Agreement (including, but not limited to, the Mimetica and Opal discovery platforms or any compound or molecule in the Kinex libraries other than the Compounds). Kinex
expressly reserves and retains the right to develop or manufacture Licensed Products within the Territory for sale outside the Territory. 

ARTICLE 3 
 INFORMATION
TRANSFER; DEVELOPMENT AND COMMERCIALIZATION; 
 REGULATORY MATTERS 

3.1 Information and Transfer of Kinex Intellectual Property. As soon as practicable, but in no event later than thirty (30) days
after the Effective Date, Kinex shall disclose and deliver to PharmaEssentia electronic copies (or, upon PharmaEssentia ‘s request, copy of the originals) of all Data for continued Development and Commercialization in the Territory. In addition
to the foregoing, Kinex shall provide PharmaEssentia with such assistance as PharmaEssentia may reasonably request (at PharmaEssentia’s cost and expenses) in connection 

  
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with the foregoing disclosures, including making available at their place of employment (or such other location as the Parties may mutually agree upon) the assistance of such persons that were
involved with the Kinex Intellectual Property. 
 3.2 Development and Commercialization. 

(a) General. PharmaEssentia shall be responsible for and shall itself, or through its Affiliates or sublicensees, conduct Development
and Commercialization in the Territory in the Field during the Agreement Term as described by this Agreement. Within 60 days after the Effective Date, PharmaEssentia shall prepare a draft plan and budget (in English) for Development and
Commercialization in each of the countries within the Territory and submit such draft plan to the Development and Commercialization Steering Committee (as defined in Section 3.4) which will agree on and oversee the plan for Development and
Commercialization during the Agreement Tenn. If PharmaEssentia fails to (i) prepare the draft plan and budget within 60 days of the Effective Date, (ii) complete a proof of concept study by December 31, 2013, (iii) commence
a Phase III Clinical Study in the Territory by September 30, 2015, (iv) file an application for Regulatory Approval in either Taiwan or Mainland China by December 31, 2016, or (v) achieve First Commercial Sale of Licensed Product
in each country in the Territory within 60 days of the Regulatory Approval in such country in the Territory, all rights and licenses under this Agreement shall immediately terminate, provided, however, Kinex shall grant a six month extension on
any of the foregoing timelines at the reasonable request of PharmaEssentia prior to any termination of this Agreement. 
 (b) Summary
Reports. Upon Kinex’s sixty (60) day prior written request, made within thirty (30) days of the end of the first Calendar Year following the Effective Date and each year thereafter during the Agreement Term, PharmaEssentia shall
provide Kinex with a written summary of Development and Commercialization undertaken on a country by country basis during the then current Calendar Year consistent with written reports issued by PharmaEssentia in the ordinary course of its business.

  
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 (c) Clinical Studies. PharmaEssentia will be responsible for, and conduct and
administer at its sole cost and expense, all the studies required for Regulatory Approval in each of countries within the Territory. Specifically, PharmaEssentia will: 

(i) Select the lead Compound for development (KX01 or KX02); 

(ii) Complete all formulation studies, skin penetration tests, skin irritation tests and skin sensitization tests necessary for
submission of an IND; 
 (iii) Conduct at least one proof of concept study before December 31, 2013 (projected to have
the first study completed as early as late 2012); 
 (iv) Conduct all Clinical Studies in the Territory in support of the
clinical strategy for psoriasis indications as identified in the Development Plan approved by the Development and Commercialization Steering Committee; and 

(v) Participate in the global Phase III Studies in such a manner in conjunction with Kinex that will support the approval of
Licensed Product in each of the countries within the Territory. 
 Any failure to comply with the foregoing will be considered a breach of
this Agreement. 
 (d) Referencing Data. The Data and results of any Clinical Studies or other studies conducted by a Party or its
ex-Territory partners shall be made available to the other Party for referencing at no cost to the requesting Party for regulatory filing purposes, and each party hereby grants to the other Party a right of reference to use such Data for the
Development 

  
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and Commercialization of the Compounds and Licensed Products, provided, however, that with respect to the right granted to PharmaEssentia, such right shall be limited to the Development and
Commercialization of the Compounds and the Licensed Products in the Field in the Territory. 
 (e) Payment of Development and
Commercialization Costs. PharmaEssentia shall be responsible for all costs associated with Development and Commercialization of Licensed Products in the Territory. Notwithstanding the generality of the foregoing, PharmaEssentia shall reimburse
Kinex for the direct costs incurred by Kinex in carrying out any Development within the Territory that was authorized or approved in writing in advance by PharmaEssentia. 

(f) Records. Under this Agreement, PharmaEssentia shall maintain records, in sufficient detail and in good scientific manner
appropriate for patent and regulatory purposes and in accordance with good industry practice, which shall be complete and accurate in all material respects and shall fully and properly reflect all work done and results achieved, including all
Know-How and including individual case report forms, in the form required by applicable Laws. 
 (g) Promotional Materials and
Activities. PharmaEssentia shall create and develop the advertising and promotional materials for the Licensed Products in the Territory with the written approval of Kinex (which shall not be unreasonably withheld) with respect to all such
materials. As holder of the Regulatory Approvals in the Territory, PharmaEssentia shall be responsible for all submissions and interactions with the Regulatory Authorities regarding approval of all Licensed Product-related promotional materials that
require Regulatory Approval. 
 (h) Ownership of Copyrights and Trademarks. Kinex retains all rights to establish a global brand for
each Licensed Product and shall own all Copyrights and Trademarks 

  
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for the Licensed Product in the Territory. PharmaEssentia shall be responsible for searching, clearing and filing applications for registration of all such Copyrights, Trademarks and trade dress
at its sole cost in accordance with Kinex’s global branding strategy. Kinex shall execute all documents and take all actions as are reasonably requested by PharmaEssentia with respect to such filings and registrations. 

(i) Sales of Licensed Products. All sales of Licensed Products shall be made, recorded, invoiced and collected by PharmaEssentia. All
terms regarding Licensed Product sales, including terms respecting credit, pricing, cash discounts, rebates, chargebacks, bad debt write-offs, and other fees and charges, and returns and allowances shall be set solely by PharmaEssentia. 

(j) Compliance with Laws. PharmaEssentia shall in all respects comply with all applicable laws and applicable guidelines concerning the
advertising, sales and marketing of prescription drug products in Commercializing Licensed Products in the Territory under this Agreement, including without limitation, the US Foreign Corrupt Practices Act of 1977, as amended (“FCPA”) and
any applicable local anti-bribery laws. PharmaEssentia represents and warrants to Kinex that, (a) as of the Effective Date, PharmaEssentia and its Affiliates have a system of internal accounting controls in place that are sufficient to provide
reasonable assurances of compliance as required by the FCPA, and (b) PharmaEssentia shall obligate any sublicensees that it or its Affiliates may engage with respect to Licensed Products to do the same; to bring any non-compliance therewith
(should it ever occur) by any of the foregoing entities to PharmaEssentia’s attention; and to promptly remedy any such non-compliance. PharmaEssentia and its Affiliates shall maintain such procedures throughout the Agreement Term and shall
promptly notify Kinex in writing with respect to any material non-compliance (other than non-compliance of the FCPA which shall be without regard to materiality) regarding Commercialization of Licensed Products. 

  
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 3.3 Regulatory Matters. 

(a) PharmaEssentia Responsibility. 

From and after the Effective Date: 

(i) PharmaEssentia shall have sole authority and responsibility for the timely preparation, filing and prosecution of all
filings, submissions, authorizations or approvals with Regulatory Authorities, and shall own and control all such filings, submissions, authorizations and approvals, including any IND, NDA or other Drug Approval Application in the Territory.
PharmaEssentia shall provide copies of all such filings, submissions, authorizations and approvals upon reasonable request from Kinex, at PharmaEssentia’s sole cost and expense. 

(ii) PharmaEssentia shall be the primary contact with each Regulatory Authority in the Territory and shall be solely
responsible for all communications with each Regulatory Authority that relate to any IND, NDA, or other Drug Approval Application in the Territory, provided, however, that upon the reasonable request of PharmaEssentia, Kinex shall
provide appropriate personnel to participate in discussions with a Regulatory Authority regarding the regulatory review process and shall assist and consult with PharmaEssentia in applying for Regulatory Approval at PharmaEssentia’s cost and
expense. 
 (iii) From and after receipt of each Regulatory Approval, PharmaEssentia shall have exclusive authority and
responsibility to submit all reports or amendments necessary to maintain Regulatory Approvals and to seek revisions of the conditions of each such Regulatory Approval in the Territory and shall keep Kinex promptly informed of any such actions.
PharmaEssentia shall have sole authority and responsibility to seek and/or obtain any necessary approvals of any Product Label, or 

  
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prescribing information, package inserts, monographs and packaging used in connection with a Licensed Product, as well as promotional material used in connection with a Licensed Product, and for
determining whether the same requires Regulatory Approval in the Territory. 
 (b) Regulatory Cooperation. Each Party is responsible
concerning adverse drug reactions, safety information and compliance with regulatory requirements. PharmaEssentia is responsible for providing any such data to Kinex that is required by the United States Regulatory Authority. The Parties hereby
agree that they will each make Commercially Reasonable Efforts in coordinating their respective regulatory, Development and Commercialization efforts. 

(c) Pharmocovigilence. During the Agreement Term, each of the Parties will notify appropriate Regulatory Authorities in accordance with
applicable law, and the other Party, promptly after receipt of information with respect to any serious adverse event (as defined by the ICH Harmonized Tripartite Guideline on Clinical Safety Data Management), directly or indirectly attributable to
the use or application of any Compound or Licensed Product. 
 (d) Product Recalls. If any Regulatory Authority having jurisdiction
in the Territory requires or reasonably requests to recall a Licensed Product due to a defect in the manufacture, processing, packaging or labeling of such Licensed Product or for any other reason whatsoever, PharmaEssentia shall immediately notify
Kinex. PharmaEssentia shall have the sole right and responsibility, at its expense, to initiate all recall procedures required or requested by any such Regulatory Agency. PharmaEssentia shall have be responsible, at its expense, for carrying out any
such recall as expeditiously as possible and in such a way as to cause the lease disruption to the sales of the Licensed Product and to preserve the goodwill and reputation attached to the Licensed Product and to the names of PharmaEssentia and
Kinex. PharmaEssentia agrees to maintain the appropriate record and procedures to permit the recall of the Licensed Product. 

  
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 3.4 Appointment and Administration of Development and Commercialization Steering Committee
for the Territory. 
 (a) As soon as practicable after the execution of this Agreement and in no event later than thirty (30) days
after the Effective Date, the Parties will establish a four (4) person steering committee to oversee and review the Development and Commercialization of the Products in the Territory, which will include two (2) representatives of each of
PharmaEssentia and Kinex (the Development and Commercialization Steering Committee) and will be chaired by one of the representatives of PharmaEssentia. All actions, decisions and approvals of the Development and Commercialization
Steering Committee shall be unanimous. One member appointed by each Party will be a senior officer of such Party who is either (i) responsible for product development or (ii) has substantial experience in product development for similar
products who is acceptable to the other Party. Each Party, at its sole discretion, may at any time during the Term of this Agreement replace a member it has the right to designate upon prior written notice to the other Party. Each Party will use
reasonable efforts to cause its respective representatives to attend all meetings of the Development and Commercialization Steering Committee. Each Party will bear the travel and out-of-pocket expenses incurred by its members or representatives in
connection with the Development and Commercialization Steering Committee’s meetings. 
 (b) The Development and Commercialization
Steering Committee will meet at least once every Calendar Quarter, or more or less frequently as the Parties mutually deem appropriate, on dates and at times and places as agreed by the Parties. The Development and Commercialization Steering
Committee may also convene or be polled or consulted from time to time by means of telecommunications, video conferences or correspondence, as deemed by the Parties to be necessary or appropriate. 

  
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 (c) If there is a disagreement within the Development and Commercialization Steering
Committee, the members of the Development and Commercialization Steering Committee shall promptly present the disagreement to the executive of each of PharmaEssentia and Kinex who has the principal responsibility for his respective company’s
work under this Agreement. Once infollued, such executives shall meet to discuss each party’s view and to explain the basis for such disagreement. If such executives are unable to resolve such dispute with thirty (30) days of such meeting,
then (a) if the disagreement is within the framework of this Agreement, then the disagreement shall be submitted to arbitration, or (b) if the disagreement is not within the framework of this Agreement and is applicable only to issues in
the Territory, then PharmaEssentia’s decision will be final and binding. Any arbitration shall be conducted in Hong Kong in accordance with commercial arbitration rules of the International Chamber of Commerce. 

(d) The Development Steering and Commercialization Committee will have final decision making authority in the Territory concerning
(i) approval and amendment, from time to time, of the plan for Development and Commercialization, (ii) the protocols for Clinical Trials of Licensed Products, (ii) approval of all contracts relating to the Development of Licensed
Product, (iii) the formulation used in respect of Licensed Product, and (iv) contracts relating to the Commercialization of Licensed Product. 

  
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 ARTICLE 4 

PAYMENTS AND STATEMENTS 

4.1 Milestone Fees. In consideration of the rights granted by Kinex hereunder, PharmaEssentia shall pay Kinex the following milestone
fees, contingent upon occurrence of the specified event, with each milestone fee to be paid no more than once with respect to the achievement of such milestone event (but payable the first time such milestone event is achieved): 

 

							
	 (a)
	  	Effective Date	  	 	US$40,000	  
			
	 (b)
	  	Completion of a proof of concept study that meets the criteria established by the Development and Commercialization Steering Committee	  	 	US$***	  
			
	 (c)
	  	Completion anywhere in the Territory of one Phase II Clinical Study that achieves the primary clinical endpoint set forth in the protocol	  	 	US$***	  
			
	 (d)
	  	Completion anywhere in the Territory of one Phase III Clinical Study that achieves the primary clinical endpoint set forth in the protocol	  	 	US$***	  
			
	 (e)
	  	Regulatory Approval in any country in the Territory	  	 	US$***	  

 Each milestone fee shall be deemed earned as of the achievement of the related milestone event and shall be
paid by PharmaEssentia within thirty (30) Business 

  
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Days after the achievement of each milestone event. Once a Licensed Product achieves a milestone, it will be deemed to have achieved also all earlier milestones, and any payment for such earlier
milestones shall be due and payable to the extent they have not already been paid. 
 With respect to the US $*** milestone fee under
(e) above, Kinex will consider and decide, in its sole discretion, whether it will agree to receive one-half in cash and one-half in shares of the capital stock of PharmaEssentia upon the written request of PharmaEssentia made at the time such
milestone fee is due and payable. 
 4.2 Royalties. 

(a) During each Calendar Quarter that royalties are due and payable to Kinex, PharmaEssentia shall, pursuant to Section 4.3(a), pay to
Kinex a royalty on annual (Calendar Year) aggregate Net Sales of Licensed Product by PharmaEssentia and it Affiliates (“Royalties”) based upon the following rates (annual Net Sales is the aggregated total of all sales in the Territory):

  

					
	(i)	  	For the amount of such annual Net Sales <US $50M	  	***%
			
	(ii)	  	For the amount of such annual Net Sales > US $50M	  	***%

 (b) The tiered royalty rates set forth above shall be reduced by forty percent (40%) for a Licensed
Product sold in any country in which Generic Competition exists for such Licensed Product; provided, however, that if Substantial Level Generic Competition exists for such Licensed Product in a country, no further Royalties shall be
payable by PharmaEssentia to Kinex with respect to such Licensed Product in the subject country. 
 (c) During each Calendar Quarter during
the Agreement Term, PharmaEssentia shall, pursuant to Section 4.3(a), pay to Kinex (i) a royalty on annual (Calendar 

  
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Year) aggregate Net Sales of all Licensed Products by all sublicensees equal to the lesser of (A) Fifty Percent (50%) of all royalties payable by the sublicensees to PharmaEssentia
based on Net Sales (or a comparable definition) of the sublicensee as provided for in the applicable sublicense agreement or (B) the amount payable if such sublicensee royalty is calculated under Section 4.2(a) based on the Net Sales of
the sublicensee, plus (ii) an amount equal to Fifty Percent (50%) of all payments received by PharmaEssentia from all sublicensees during the applicable Calendar Quarter that are not calculated based on Net Sales (or a comparable
definition) (“Sublicensee Royalties and Payments”). 
 4.3 Royalty Reports and Payments. 

(a) Royalty Payments. Within sixty (60) days following the end of each Calendar Quarter that Royalties or Sublicensee Royalties
and Payments are payable by PharmaEssentia to Kinex, PharmaEssentia shall submit to Kinex a written report containing, with respect to such Calendar Quarter and for the then-current Calendar Year through the end of such Calendar Quarter, an
accounting on a country-by-country basis of gross sales, Net Sales of PharmaEssentia, its Affiliates and sublicensees, Royalties, and Sublicensee Royalties and Payments payable in accordance with Section 4.2(a) and (c) for such Calendar
Quarter, with a breakdown of all deductions taken in any such calculations, in accordance with the definition of “Net Sales”. Any conversion to United States Dollars shall be calculated in accordance with Section 4.4(c). In the event
of any royalty reduction during any Calendar Quarter due to Generic Competition in any country in the Territory, the report for such Calendar Quarter shall also show the basis for the determination of such Generic Competition. Royalties and
Sublicensee Royalties and Payments shown to have accrued by each report shall be due and payable on the date such report is due. 
 (b)
Following the expiration of all Royalties and Sublicensee Royalties and Payments payable to Kinex on any Licensed Product in a country, PharmaEssentia shall continue 

  
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to furnish Kinex a written report on a country-by-country basis for the next four Calendar Quarters following expiration of all royalties and payments with respect to such Licensed Product, and
shall state the basis for Net Sales then being free of royalty obligations hereunder. PharmaEssentia shall thereafter have no further obligation to include in a report the Net Sales of such Licensed Product in such country for purposes of the
royalty calculation for any Calendar Quarter. This obligation shall survive the termination or expiration of this Agreement in any country. 

(c) Each Party shall keep and shall require its Affiliates to keep complete and accurate records in sufficient detail to permit accurate
determination of all amounts necessary for calculation and verification of all payment obligations set forth in this Article 4 for a period of 36 months from the end of the relevant Calendar Quarter. 

4.4 General Payment Provisions. 

(a) Payment Method. All payments under this Agreement shall be made in United States Dollars by bank wire transfer in immediately
available funds to an account designated by Kinex. 
 (b) Withholding Taxes. With respect to the milestone fees, PharmaEssentia shall
act as the tax agent of Kinex and make all required withholding or other tax payments to, and file all appropriate tax form with, the Taiwanese taxing authority(ies) at its expense on behalf of Kinex without any reduction in the foregoing milestone
fee payments to Kinex. PharmaEssentia shall indemnify, hold harmless and defend Kinex with respect to any claim made against Kinex by any Taiwanese taxing authority(ies) for unpaid taxes with respect to the milestone fees. 

With respect to all other payments under this Agreement, PharmaEssentia may deduct the amount of any taxes imposed on Kinex which are required
to be withheld or collected by 

  
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PharmaEssentia, its Affiliates or sublicensees under the laws, rules or regulations of any country on amounts owing from PharmaEssentia to Kinex hereunder. Any such taxes required to be withheld
or collected shall be an expense of Kinex. 
 Kinex shall provide PharmaEssentia any tax forms that may be reasonably necessary in order for
PharmaEssentia to not withhold tax or to withhold tax at a reduced rate and PharmaEssentia shall apply the reduced rate of withholding, or dispense with withholding, as the case may be. Each Party shall provide the other with reasonable assistance
to enable the recovery, as permitted by applicable laws, of withholding taxes, value added taxes, and similar obligations resulting form payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding
tax or value added tax. To the extent PharmaEssentia, its Affiliates or sublicensees pay such withholding taxes to the appropriate governmental authority on behalf of Kinex; PharmaEssentia shall promptly deliver to Kinex proof of payment of such
taxes. 
 (c) Currency Exchange. For purposes of computing royalties on Net Sales in any country outside the United States, the Net
Sales shall be converted to United States Dollars using the year-to-date average rate of exchange for United States Dollars used by PharmaEssentia for its internal financial accounting purposes; provided, however, that if for any
reason conversion into United States Dollars cannot be made in a country in the Territory, then notwithstanding the provisions of Section 4.4(a), payment may be made in the currency of such country by deposit in the name of Kinex in a bank
account designated by Kinex in such country. 
 (d) Except as otherwise defined herein, all financial calculations by either Party under
this Agreement shall be calculated in accordance with IFRS. In addition, all calculations shall give pro rata effect to and shall proportionally adjust (by giving effect to the number of applicable days in such Calendar Quarter) (i) for
any Calendar Quarter that is shorter than a standard Calendar Quarter or any Calendar Year that is shorter than four consecutive full 

  
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Calendar Quarters, or (ii) as a result of a determination, in accordance with the terms of this Agreement, that the first or last day of such Calendar Quarter (including as a result of
termination of this Agreement) shall be deemed other than the actual first or last day of such Calendar Quarter, or that the first or last day of such Calendar Year shall be deemed other than the actual first or last day of such Calendar Year. 

4.5 Audits. Upon the written request of Kinex, PharmaEssentia shall permit an independent certified public accounting firm of
recognized standing, selected by Kinex and reasonably acceptable to PharmaEssentia (provided that such accounting firm shall not be retained or compensated on a contingency basis and shall have entered into a confidentiality agreement
with PharmaEssentia in form and substance reasonably satisfactory to PharmaEssentia), to have access not more than once in any Calendar Year, during normal business hours, to such of the records of PharmaEssentia as may be reasonably necessary to
verify the accuracy of the reports under Section 43 hereof for any year ending not more than twenty-four (24) months prior to the date of such request. The accounting firm shall disclose to Kinex whether the reports are correct or
incorrect, the specific details concerning any discrepancies (including the accuracy of the calculation of Net Sales and the resulting effect of such calculations on the amounts payable by PharmaEssentia under this Agreement) and such other
information that should properly be contained in a report required under this Agreement (the “Audit Report”) 
 (a) If such
accounting firm concludes that additional amounts were owed during such year, and PharmaEssentia agrees with such conclusion, then the PharmaEssentia shall pay the additional payments, together with interest at the Prime Rate on the amount of such
additional payments, within thirty (30) days of the date Kinex delivers the Audit Report to PharmaEssentia. If such accounting firm concludes that amounts were overpaid by PharmaEssentia during such period, Kinex shall repay PharmaEssentia the
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overpayment, together with interest at the Prime Rate on the amount of such overpayment, within thirty (30) days of the date Kinex delivers the Audit Report to PharmaEssentia. The fees
charged by such accounting firm shall be paid by Kinex; provided, however, that if an error in favor of Kinex of more than five percent (5%) of the payments due hereunder for the period being reviewed is discovered, then the fees
and expenses of the accounting firm shall be paid by PharmaEssentia. 
 (b) Upon the expiration of twenty-four (24) months following
the end of any year for which PharmaEssentia or Kinex has made payment in full of amounts payable with respect to such year, and in the absence of negligence or willful misconduct of PharmaEssentia or Kinex or a contrary finding by an accounting
firm pursuant to Section 4.5(a), such calculation shall be binding and conclusive upon PharmaEssentia or Kinex, and PharmaEssentia or Kinex, as applicable, shall be released from any liability or accountability with respect to royalties or
other payments for such year. 
 ARTICLE 5 

REPRESENTATIONS AND WARRANTIES 

5.1 General Representations. Each Party hereby represents and warrants to the other Party as follows: 

(a) Such Party is a corporation duly organized, validly existing and is in good standing under the laws of the jurisdiction of its
incorporation, is qualified to do business and is in good standing as a foreign corporation in each jurisdiction in which the conduct of its business or the ownership of its properties requires such qualification and failure to have such would
prevent it from performing its obligations under this Agreement; 
 (b) The execution, delivery and performance by such Party of this
Agreement has been duly authorized by all necessary corporate action and do not and will not (i) violate any 

  
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provision of any law, rule, regulation, order, writ, judgment, injunction, decree, determination or award presently in effect having applicability to it or any provision of its charter or bylaws;
or (ii) conflict with or constitute a default under any other agreement to which such Party is a party; 
 (c) This Agreement has been
duly executed and is a legal, valid and binding obligation of such Party, enforceable against it in accordance with the terms and conditions hereof, except as enforceability may be limited by (i) any applicable bankruptcy, insolvency,
reorganization, moratorium or similar law affecting creditor’s rights generally, or (ii) general principles of equity, whether considered in a proceeding in equity or at law; 

(d) Such Party is not under any obligation to any person or entity, contractual or otherwise, that is in conflict with the terms of this
Agreement, nor shall such Party undertake any such obligation during the Agreement Term; 
 (e) Such Party has obtained all authorizations,
consents and approvals, governmental or otherwise, necessary for the execution and delivery of this Agreement, and to otherwise perform such Party’s obligations under this Agreement; 

(f) Neither Party, nor any of its Affiliates, are a party to, or are otherwise bound by, any oral or written contract that will result in any
person or entity obtaining any interest in, or that would give to any Third Party any right to assert any claim in or with respect to, any of such Party’s or the other Party’s rights under this Agreement; and 

(g) Such Party shall perform its obligations hereunder in accordance with all applicable Laws. 

  
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 5.2 Additional Representations and Warranties of Kinex. Kinex represents and warrants
to PharmaEssentia that: 
 (a) As of the Effective Date in the Territory, to the knowledge of Kinex, (i) there is no Third Party
infringement of any of the Kinex Intellectual Property; and (ii) the Kinex Intellectual Property is in full force where filed; (iii) the Kinex Patent Rights where filed are not subject to any pending or threatened re-examination, re-issue,
opposition, interference, challenge, litigation proceeding or other claim, and (iv) Kinex has only filed or prosecuted patent applications with respect to the Kinex Intellectual Property in the countries in the Territory as set forth on
Schedule 1.2 to this Agreement; 
 (b) To the knowledge of Kinex, Kinex has not committed any act, or omitted to commit any act, that
may cause the Kinex Patent Rights where filed to expire prematurely or be declared invalid or unenforceable, or that stops Kinex from enforcing the Kinex Patent Rights where filed against any Third Party; 

(c) As of the Effective Date in the Territory, (i) Kinex has the right to use and disclose and to enable PharmaEssentia to use and
disclose (in each case under appropriate conditions of confidentiality) the Kinex Know-How; and (ii) the Kinex Intellectual Property is not subject to any encumbrance, lien, license or claim of ownership by any Third Party that would conflict
with the terms of this Agreement; 
 (d) At no time during the Agreement Term shall Kinex assign, transfer, encumber or grant rights in or
with respect to the Kinex Intellectual Property inconsistent with the rights granted to PharmaEssentia under this Agreement; and 
 (e) The
Data and information provided to PharmaEssentia or its Affiliates prior to the Effective Date relating to pre-clinical studies in the Field related to Compounds has been accurate in all respects and Kinex has made no misrepresentation or omission in
connection with such Data and information. Kinex has also provided PharmaEssentia or its Affiliates with access to summaries of all adverse events known to Kinex relating to the Compounds. 

  
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 5.3 Additional Representations and Warranties of PharmaEssentia. PharmaEssentia
represents and warrants to Kinex that: 
 (a) At no time during the Agreement Term shall PharmaEssentia assign, transfer, encumber or grant
rights in or with respect to the PharmaEssentia Intellectual Property inconsistent with the rights granted to Kinex under this Agreement including under Section 8.3(d). 

ARTICLE 6 
 PATENT
MATTERS 
 6.1 Ownership of Inventions. 

(a) Except as otherwise provided in and subject to the terms of this Agreement, as between the Parties: 

(i) Kinex shall have and retain all right, title and interest in or Control over, as applicable, all Intellectual Property (and
Patent Rights arising thereunder) existing, owned or Controlled by it on the Effective Date, subject to the licenses and other rights for the specified Territory granted to PharmaEssentia under this Agreement. For all countries outside the
Territory, Kinex will also have all right, title and interest in or Control over all Intellectual Property (and Patent Rights arising thereunder) which is discovered, made, first conceived, reduced to practice or generated (whether solely or jointly
by employees, agents or other persons of Kinex or PharmaEssentia) under this Agreement as a result of Development or otherwise during the Agreement Term that are necessary or useful for Development or Commercialization of the Licensed Products. 

(ii) For all countries within the Territory, PharmaEssentia shall have and retain all right, title and interest in or Control
over all Intellectual Property (and 

  
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Patent Rights arising thereunder) which is discovered, made, first conceived, reduced to practice or generated (whether solely or jointly by employees, agents or other persons of Kinex or
PharmaEssentia) under this Agreement in the Territory as a result of Development or otherwise during the Agreement Term that are necessary or useful for the Development or Commercialization of the Licensed Products. 

(b) Employees and Agents. Each of Kinex and PharmaEssentia shall require all of its and its Affiliates’ employees to assign all
inventions and corresponding patent applications and that are discovered, made, first conceived, reduced to practice or generated by such employees during the Agreement Term to Kinex or PharmaEssentia according to the ownership principles described
in Section 6.1(a). Each Party shall use Commercially Reasonable Efforts to require any Third Parties working on any Clinical Study or any Development under the Agreement or who receive materials relating to Licensed Product or Know-How from a
Party, to assign ownership or grant a sublicenseable exclusive license on a fully paid-up, royalty-free basis to all inventions and corresponding Patent Rights that are developed, made or conceived by such Third Parties during the Agreement Term to
Kinex or PharmaEssentia according to the ownership principles described in Section 6.1(a). 
 6.2 Maintenance and Prosecution.

 (a) Kinex Patent Rights. Kinex shall have the first right to file, prosecute and maintain the Kinex Patent Rights in Kinex’s
name, using patent counsel selected by Kinex and shall be responsible for the payment of all patent prosecution and maintenance costs. Kinex will inform PharmaEssentia on the patent applications in the Territory. As of the Effective Date, the Kinex
Patent Rights in the Territory include only those applications set forth in Schedule 1.2 to this Agreement and Kinex retains the right to determine whether to file for patents in any additional countries within the Territory. If Kinex elects
not to prosecute or maintain a patent application or patent included in the Kinex Patent Rights in the Territory, it shall provide 

  
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PharmaEssentia with no less than forty-five (45) days’ written advance notice sufficient to avoid any loss or forfeiture, and subject to Kinex’s prior written consent,
PharmaEssentia shall then have the right, but not the obligation, at its sole expense, to maintain such Patent Right in the Territory. 

(b) PharmaEssentia Patent Rights. PharmaEssentia shall have the first right to file, prosecute and maintain the PharmaEssentia Patent
Rights in PharmaEssentia’s name, using patent counsel selected by PharmaEssentia and shall be responsible for the payment of all patent prosecution and maintenance costs. PharmaEssentia will inform Kinex on the patent applications in the
Territory. If PharmaEssentia elects not to file, prosecute or maintain a patent application or patent included in the PharmaEssentia Patent Rights, it shall provide Kinex with no less than forty-five (45) days’ written advance notice
sufficient to avoid any loss or forfeiture, and subject to PharmaEssentia’s prior written consent, Kinex shall then have the right, but not the obligation, at its sole expense, to file, prosecute or maintain such Patent Right. 

(c) The responsible Party under this Section 6.2 shall solicit the other Party’s review of the nature and text of any patent
applications within the Territory resulting from Development or otherwise during the Agreement Term that are necessary or useful for the Development or Commercialization of the Licensed Products and important prosecution matters related thereto in
reasonably sufficient time prior to the filing thereof, and the responsible Party shall take into account the other Party’s reasonable comments related thereto. Each Party shall execute all documents and take all actions as are reasonably
requested by the other Party with respect to any filings and registrations. 
 6.3 Third Party Infringement. 

(a) Each Party shall promptly give the other Party notice of any actual or suspected infringement by a Third Party in the Territory of any
patent included in the Kinex 

  
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Patent Rights or PharmaEssentia Patent Rights relating to the Compounds or Licensed Products (collectively, the “Parties’ Patent Rights”), which comes to such Party’s
attention. In addition, PharmaEssentia shall promptly give Kinex notice of any actual or suspected infringement by a Third Party outside the Territory of any patent included in the Kinex Patent Rights. The Parties shall thereafter consult and
cooperate to determine a course of action, including the commencement of legal action with respect to any infringement within the Territory. 

(b) Kinex shall have the first right, either directly or through its Affiliates or licensees, to initiate and prosecute such legal action in
the Territory at its own expense and in the name of Kinex and/or PharmaEssentia, or to control the defense of any declaratory judgment action in the Territory relating to the Parties’ Patent Rights, and Kinex shall provide PharmaEssentia with
reasonable notice of any such action it commences and keep PharmaEssentia reasonably informed of any significant developments in such action. PharmaEssentia shall render, at its expense (including reasonable attorneys’ fees), all assistance
reasonably requested in connection with any action taken by Kinex or to prevent such infringement. However, the control of such action, including whether to initiate any legal proceeding and/or the settlement thereof, shall solely be under the
control of Kinex; provided that Kinex shall not settle any such claim or proceeding in a manner that materially adversely affects PharmaEssentia’s rights under this Agreement or which results in any material monetary payment by or
financial loss to PharmaEssentia, without the prior written consent of PharmaEssentia, which consent shall not be unreasonably withheld. 

(c) If Kinex elects not to initiate and prosecute an infringement or defend a declaratory judgment action in any country in the Territory as
provided in Section 6.3(b) within sixty (60) days after having become aware of such potential infringement, then PharmaEssentia may elect, which election shall be subject to the prior written consent of Kinex to take such action that is
reasonably necessary and appropriate to terminate or prevent such infringement, 

  
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including instituting an infringement proceeding, provided, however, that PharmaEssentia shall not enter into any settlement or compromise of any claim relating to the Parties’
Patent Rights licensed hereunder or which results in any material monetary payment by or financial loss to Kinex, without Kinex’s prior written consent, which consent shall not be unreasonably withheld. 

(d) Kinex shall have the sole right, either directly or through its Affiliates or licensees to initiate and prosecute any legal action outside
the Territory with respect to the Kinex Patent Rights at its own expense or to control the defense of any declaratory judgment action outside the Territory. PharmaEssentia shall render, at its expense, all assistance reasonably requested in
connection with any action taken by Kinex or to prevent such infringement. However, the control of such action, including whether to initiate any legal proceeding and/or the settlement thereof, shall solely be under the control of Kinex. 

(e) For any legal action or defense contemplated by this Section 6.3, in the event that any Party is unable to initiate, prosecute, or
defend such action solely in its own name, the other Party will join such action voluntarily and will execute all documents necessary for the Party to prosecute, defend and maintain such action. In connection with any such action, the Parties will
cooperate fully and will provide each other with any information or assistance that either reasonably may request. Any recovery or award obtained by either Party as a result of any action or settlement commenced with respect to infringement within
the Territory shall be shared as follows: 
 (i) the Party that initiated and prosecuted, or maintained the defense of, the
action shall recoup all of its costs and expenses (including reasonable attorneys’ fees) incurred in connection with the action, whether the recovery is by settlement or otherwise; 

  
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 (ii) the other Party then shall, to the extent funds remain after payment set
forth in subsection (i) has been made, recover its reasonably documented costs and expenses (including reasonable outside attorneys’ fees) incurred in connection with the action; 

(iii) if Kinex initiated and prosecuted, or maintained the defense of, the action outside the Territory, the amount of any
recovery remaining then shall be retained by Kinex; and 
 (iv) if PharmaEssentia or Kinex initiated and prosecuted, or
maintained the defense of, the action in the Territory, the amount of any recovery remaining then shall be shared equally by the parties. 

6.4 Third Party Intellectual Property. 

(a) In the event that a Party becomes aware of any claim that the development, manufacture, import, use, marketing or sale of Licensed Product
hereunder infringes the intellectual property rights of any Third Party in the Territory, such Party shall promptly notify the other Party. The Parties shall thereafter discuss the situation, and to the extent reasonably necessary, attempt to agree
on a course of action. 
 (b) If within ten (10) Business Days the Parties fail to agree upon an appropriate course of action in the
Territory, Kinex shall have the first right, but not the obligation, either directly or through its Affiliates or licensees to defend any action in the Territory related to the intellectual property rights of any Third Party or to initiate and
prosecute legal action in the Territory related to the intellectual property rights of any Third Party in the name of PharmaEssentia and/or Kinex. Kinex shall keep PharmaEssentia reasonably informed as to the progress of any such action.
PharmaEssentia shall render, at its expense, all assistance reasonably requested in connection with any action taken by Kinex. However, the control of 

  
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such action, including whether to initiate any legal proceeding and/or the settlement thereof, shall solely be under the control of Kinex; provided that Kinex shall not settle any such
claim or proceeding in a manner that materially adversely affects PharmaEssentia’s rights under this Agreement or which results in any material monetary payment by or financial loss to PharmaEssentia, without PharmaEssentia’s written
consent, which consent shall not be unreasonably withheld. Kinex shall pay for all costs and expenses incurred in such defense. In addition, Kinex shall pay all damages awarded or settlement payments made (including future royalty or similar
payments) to such Third Party. 
 (c) If Kinex elects not to defend an infringement action in any country in the Territory as provided in
Section 6.4(b), and PharmaEssentia elects to do so, which election shall be subject to the prior written consent of Kinex, the cost of any agreed-upon course of action, including the costs of any legal action commenced or any infringement
action defended, shall be borne solely by PharmaEssentia, provided, however, that PharmaEssentia shall not enter into any settlement or compromise of any claim without the prior written consent of Kinex, which consent shall not be
unreasonably withheld. 
 (d) For any such legal action or defense, in the event that any Party is unable to initiate, prosecute, or defend
such action solely in its own name, the other Party will join such action voluntarily and will execute all documents necessary for the Party to prosecute, defend and maintain such action. In connection with any such action, the Parties will
cooperate fully and will provide each other with any information or assistance that either reasonably may request. 
 (e) Kinex shall have
the sole right, but not the obligation, either directly or through its Affiliates or licensees to defend any action related to the intellectual property rights outside the Territory of any Third Party or to initiate and prosecute legal action
outside the Territory related to the intellectual property rights of any Third Party in the name of 

  
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PharmaEssentia and/or Kinex. PharmaEssentia shall render, at its expense, all assistance reasonably requested in connection with any action taken by Kinex. However, the control of such action,
including whether to initiate any legal proceeding and/or the settlement thereof, shall solely be under the control of Kinex. 
 6.5
Patent Term Extensions. The Parties shall cooperate with each other in obtaining patent term extensions or restorations or supplemental protection certificates or their equivalents in any country in the Territory where applicable and where
desired by PhammEssentia. Elections with respect to obtaining such extension or supplemental protection certificates shall be made in the same manner and with the same relative priorities between the Parties as is applicable to the prosecution and
maintenance of Patent Rights pursuant to Section 6.2. 
 6.6 Patent Marking. PharmaEssentia shall mark, and shall require its
Affiliates and sublicensees to mark, all Licensed Products sold or distributed pursuant to this Agreement in accordance with the applicable patent statutes or regulations in the country or countries of manufacture and/or sale thereof. 

6.7 Third Party Agreements. (a) If any licensee of the Compounds from Kinex (“Third Party Licensee”) develops a
pharmaceutical preparation in final form (“Third Party Drug”) that is (i) delivered through oral dosing, (ii) contains either of the Compounds as an active pharmaceutical ingredient, (iii) is approved for use in any country
in the Territory for indications other than psoriasis, and (iv) is offered for sale as a treatment for psoriasis which is outside the scope of Regulatory Approval and outside the Third Party Licensee’s field of use for the Compounds under
its license with Kinex (“Off Label Sales”), Kinex shall have the first right, either directly or through its Affiliates, to initiate and prosecute legal action in the Territory at its own expense and in the name of Kinex to prevent Off
Label Sales of the Third Party Drug for psoriasis in the Territory, or to control the defense of any declaratory judgment action in the Territory relating to the Third Party Licensee’s field of use under its license with Kinex, and

  
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Kinex shall provide PharmaEssentia with reasonable notice of any such action it commences and keep PharmaEssentia reasonably informed of any significant developments in such action.
PharmaEssentia shall render, at its expense (including reasonable attorneys’ fees), all assistance reasonably requested in connection with any such action taken by Kinex. However, the control of such action, including whether to initiate any
legal proceeding and/or the settlement thereof, shall solely be under the control of Kinex; provided that Kinex shall not settle any such claim or proceeding in a manner that materially adversely affects PharmaEssentia’s rights under
this Agreement or which results in any material monetary payment by or financial loss to PharmaEssentia, without the prior written consent of PharmaEssentia, which consent shall not be unreasonably withheld. 

(b) If Kinex elects not to initiate and prosecute an action to prevent Off Label Sales of a Third Party Drug for psoriasis, or defend a
declaratory judgment action in any country in the Territory as provided in Section 6.7(a) within sixty (60) days after having become aware of such Off Label Sales for the treatment of psoriasis by the Third Party Licensee, then
PharmaEssentia may elect, which election shall be subject to the prior written consent of Kinex to take such action in the Territory that is reasonably necessary and appropriate to prevent such sales by the Third Party Licensee by instituting a
proceeding to enforce the limitations of the field of use contained in the license between Kinex and the Third Party Licensee, provided, however, that PharmaEssentia shall not enter into any settlement or compromise of any claim or
which results in any material monetary payment by or financial loss to Kinex or termination of its license with the Third Party Licensee, without Kinex’s prior written consent, which consent shall not be unreasonably withheld. 

(c) For any legal action or defense contemplated by this Section 6.7, in the event that any Party is unable to initiate, prosecute, or
defend such action solely in its own name, the other Party will join such action voluntarily and will execute all documents necessary for the 

  
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Party to prosecute, defend and maintain such action. In connection with any such action, the Parties will cooperate fully and will provide each other with any information or assistance that
either reasonably may request. Any recovery or award obtained by either Party as a result of any action or settlement commenced with respect to infringement within the Territory shall be shared as follows: 

(i) the Party that initiated and prosecuted, or maintained the defense of, the action shall recoup all of its costs and
expenses (including reasonable attorneys’ fees) incurred in connection with the action, whether the recovery is by settlement or otherwise; 

(ii) the other Party then shall, to the extent funds remain after payment set forth in subsection (i) has been made,
recover its reasonably documented costs and expenses (including reasonable outside attorneys’ fees) incurred in connection with the action; 

(iii) if Kinex initiated and prosecuted, or maintained the defense of, the action, the amount of any recovery remaining then
shall be shared 30% to Kinex and 70% to PhannaEssentia; and 
 (iv) if PharmaEssentia initiated and prosecuted, or maintained
the defense of, the action, the amount of any recovery remaining then shall be shared 10% to Kinex and 90% to PharmaEssentia. 
 ARTICLE 7

 CONFIDENTIALITY AND PUBLICITY 

7.1 Non-Disclosure and Non-Use Obligations. All Proprietary Information disclosed by one Party to the other Party hereunder shall be
maintained in confidence and shall not be 

  
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disclosed to any Third Party or used for any purpose except as expressly permitted herein without the prior written consent of the Party that disclosed the Proprietary Information to the other
Party during the term of this Agreement and for a period of ten (10) years thereafter. The foregoing nondisclosure and non-use obligations shall not apply to the extent that such Proprietary Information: 

(a) is known by the receiving Party at the time of its receipt, and not through a prior disclosure by the disclosing Party, as documented by
records; 
 (b) is or becomes properly in the public domain or knowledge without breach by either Party; 

(c) is subsequently disclosed to a receiving Party by a Third Party who may lawfully do so and is not under an obligation of confidentiality
to the disclosing Party; or 
 (d) is developed by the receiving Party independently of Proprietary Information received from the disclosing
Party, as documented by contemporary written records. 
 7.2 Permitted Disclosure of Proprietary Information. Notwithstanding
Section 7.1, a Party receiving Proprietary Information of another Party may disclose such Proprietary Information: 
 (a) to
governmental or other regulatory agencies in order to obtain patents pursuant to this Agreement, or to gain approval to conduct Clinical Studies or to market Licensed Product, but such disclosure may be only to the extent reasonably necessary to
obtain such patents or authorizations and in accordance with the terms of this Agreement or as otherwise requested by the Regulatory Authorities; 

(b) by PharmaEssentia to its agents, consultants, sublicensees or Affiliates in connection with the Development or Commercialization, or to
otherwise enable PharmaEssentia to fulfill its obligations and responsibilities under this Agreement, on the condition that such entities agree to be bound by confidentiality obligations consistent with this Agreement; or 

  
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 (c) if required to be disclosed by law or court order, provided that notice is
promptly delivered to the non-disclosing Party in order to provide an opportunity to challenge or limit the disclosure obligations. 
 (d)
Certain Disclosures. Except as set forth in this Agreement or as required by law, neither Party shall make any press release or other public announcement or other public disclosure to a Third Party concerning the existence of or terms of this
Agreement, the subject matter of this Agreement or the activities contemplated hereunder, without the prior written consent of the other Party, which consent shall include agreement upon the nature and text of such release, announcement or other
disclosure and shall not be unreasonably withheld or delayed. Each Party agrees to provide to the other Party a copy of any such press release or other public announcement or disclosure as soon as reasonably practicable under the circumstances prior
to its scheduled release. Each Party shall have the right to expeditiously (but in any event within forty-eight (48) hours) review and recommend changes to any such press release or other public announcement or disclosure; provided,
however, that such right of review and recommendation shall only apply for the first time that specific information is to be disclosed, and shall not apply to the subsequent disclosure of substantially similar information that has previously
been disclosed unless there have been material developments relating to Licensed Product since the date of the previous disclosure; provided, further, that each Party shall provide to the other Party reasonable advance notice of any
such subsequent disclosure. Without limiting the generality of any of the foregoing, it is understood that the Parties or their Affiliates may make disclosure of this Agreement and the terms hereof in accordance with the rules and regulations of the
SEC, other governmental authority, or securities exchange, may file this Agreement as an exhibit to any filing with the SEC, other governmental authority, or securities 

  
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exchange, and may distribute any such filing in the ordinary course of its business, provided, further, that to the maximum extent allowable by the rules and regulations of the SEC,
other governmental authority, or securities exchange, and except as required by applicable Laws, Kinex and PharmaEssentia shall seek to redact any confidential information set forth in such filings, and each Party shall provide a draft of the
redacted version of this Agreement to the other Party no less than five (5) Business Days prior to filing with the SEC, other governmental authority, or securities exchange, and give reasonable consideration to the other Party’s comments
regarding any proposed redaction. 
 7.3 Publications. PharmaEssentia shall not submit for written or oral publication any
manuscript, abstract or the like relating to the Compounds or Licensed Products, without the prior approval or written request of Kinex. If PharmaEssentia desires to submit such publication, it shall first deliver to Kinex, for Kinex’s prior
written consent, the proposed publication or an outline of the oral disclosure at least sixty (60) days prior to planned submission or presentation. 

7.4 Publicity. Except as otherwise provided in this Agreement or required by law or regulation, no Party will originate any news
release or other public announcement, written or oral, whether in the public press, stockholders’ reports or otherwise, relating to this Agreement or to any sublicense under this Agreement, or to the performance under this Agreement or under
any sublicense under this Agreement, without the prior written approval of the other Party, which approval will not be unreasonably withheld or delayed; provided that the foregoing shall not restrict disclosures made in connection with any filing of
information or materials with a stock exchange or the U.S. Securities and Exchange Commission or any stockholders’ letter to private investors. 

  
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 ARTICLE 8 

TERM AND TERMINATION 
 8.1
Term and Expiration. This Agreement shall be binding on the Parties as of the Effective Date. Thereafter, unless terminated earlier pursuant to Section 8.2 below, this Agreement shall extend for a period which may expire on a country by
country basis upon the earliest to occur of either (i) the expiration of the Kinex Patent Rights or (ii) invalidation of the Kinex Patent Rights (the “Agreement Term”). Notwithstanding the foregoing, after the occurrence
of (i) or (ii) above, the Agreement Term shall automatically be extended for consecutive one (1) year periods subject to the same terms and conditions set forth herein (unless agreed otherwise) unless either Party gives written notice
of its intention not to extend the Agreement Term: (i) at least ninety (90) days prior to the expiration date of the Kinex Patent Rights; or (ii) as soon as practically possible in the case of an invalidation claim; and
(iii) thereafter, at least ninety (90) days prior to the then current annual expiration date of the Agreement. 
 8.2 Early
Termination of Agreement Term. 
 (a) This Agreement may be terminated upon mutual agreement of the Parties. 

(b) Termination by PharmaEssentia. 

PharmaEssentia may terminate this Agreement in its sole discretion upon not less than six (6) months prior written notice of
termination provided anytime after the Effective Date (provided, however, that no such termination shall be effective until the completion of any then Ongoing Clinical Studies). The cost involved during the six-month notice period plus
any period needed for completion of any Ongoing Clinical Studies will also be borne by PharmaEssentia. In addition, if any milestone is met PharmaEssentia prior to the termination date, PharmaEssentia will also be responsible for the milestone
payment. 

  
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 (c) Termination by Either Party. 

Either Party may, without prejudice to any other remedies available to it under this Agreement or at law or in equity, terminate this
Agreement prior to expiration of the Agreement Term in the event that the other Party (as used in this subsection, the “Breaching Party”) shall have materially breached or defaulted in the performance of any of its material
obligations hereunder, and has not cured such breach within (i) thirty (30) days after notice of such breach is provided to the Breaching Party in case the breach is a non-payment of any amount due under this Agreement that is not being
disputed in good faith (which shall be deemed a material breach of a material obligation) and (ii) sixty (60) days after notice of such breach is provided to the Breaching Party for other cases of breach (or, if such default cannot be
cured within such 60-day period, if the Breaching Party does not commence and diligently continue actions to cure such default during such 60-day period). The termination shall become effective at the end of the (i) 30-day period in case the
breach is a non-payment of any amount due under this Agreement that is not being disputed in good faith if the Breaching Party has not cured such breach by such date, or (ii) for other cases of breach, 60-day period unless (a) the
Breaching Party cures such breach during such 60-day period, or (b) if such breach is not susceptible to cure within such 60-day period, the Breaching Party has commenced and is diligently pursuing a cure
(unless such breach, by its nature, is incurable, in which case the Agreement may not be terminated unless the Breaching Party fails to use its best commercially reasonable efforts to prevent a similar subsequent breach). The right of either Kinex
or PharmaEssentia to terminate this Agreement as provided in this Section 8.2(c) shall not be affected in any way by such Party’s waiver or failure to take action with respect to any previous breach or default. 

8.3 Effect of Expiration or Termination; Survival. 

(a) Expiration or termination of this Agreement shall not relieve the Parties of any obligation accruing prior to such expiration or
termination, including all accrued payment obligations arising under Article 4 hereof. In addition to any other provisions of this Agreement 

  
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which by their terms continue after the expiration of this Agreement, the provisions of Article 3.2(f), 4.3(b), 7 and 9 shall survive the expiration or termination of this Agreement and
shall continue in effect after the date of expiration or termination for the longer of (i) five (5) years after the last sale of Licensed Product in the Territory, or (ii) the respective periods specified therein. In addition,
any other provisions required interpreting and enforcing the Parties’ rights and obligations under this Agreement shall also survive, but only to the extent required for the full observation and performance of this Agreement. Any expiration or
early termination of this Agreement shall be without prejudice to the rights of any Party against the other accrued or accruing under this Agreement prior to termination. Except as expressly set forth herein, the rights to terminate as set forth
herein shall be in addition to all other rights and remedies available under this Agreement, at law, or in equity, or otherwise. 
 (b)
Payments of amounts owing to Kinex under this Agreement as of its expiration or termination shall be due and payable either (i) to the extent such amounts can be calculated and a fixed sum determined at the time of expiration or termination of
this Agreement, thirty (30) days after the date of such expiration or termination, or (ii) to the extent such amounts cannot be calculated and a fixed sum determined at the time of expiration or termination of this Agreement, thirty
(30) days after the date at which such amounts can be calculated and a fixed sum determined. 
 (c) Subject to the payment of all
amounts required hereunder, PharmaEssentia and its Affiliates shall have the right to sell or otherwise dispose of the stock of any Licensed Product subject to this Agreement on hand or in process of manufacture as of the expiration or termination
of this Agreement. Within thirty (30) days after the effective date of termination or expiration of this Agreement, PharmaEssentia shall notify Kinex of the amount of Licensed Product PharmaEssentia, its Affiliates and sublicensees then have on
hand or in the process of manufacture and shall have the right to sell in the Territory (except with respect to any country in 

  
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the Territory in which Licensed Product has been withdrawn or there is no Regulatory Approval), its remaining stock of Licensed Product for a period ending upon the earlier of:
(i) PharmaEssentia’s, its Affiliates’ and sublicensees’ sale of all such remaining Licensed Product, or (ii) six (6) months after such termination or expiration, and terms and conditions of this Agreement shall apply to
such Licensed Product so sold. Kinex hereby grants a non-exclusive license under the Kinex Intellectual Property to PharmaEssentia solely to sell such Licensed Product in the Territory, subject to payment of all related amounts due under this
Agreement. Any remaining quantities of Licensed Product not sold during this period shall, at Kinex’s election, either be destroyed by PharmaEssentia at PharmaEssentia’s cost or sold to Kinex at PharmaEssentia’s procurement cost for
such Licensed Product. 
 (d) Upon the termination or expiration of this Agreement, the following shall also be applicable: (i) at
Kinex’s request, PharmaEssentia shall promptly transfer and return to Kinex copies of all Data, reports, records and materials in PharmaEssentia’s possession or control that relate to Compound or Licensed Products and return to Kinex all
relevant records and materials in PharmaEssentia’s possession or control containing Proprietary Information of Kinex (provided that PharmaEssentia may keep one copy of such Proprietary Information of Kinex for archival purposes
only); (ii) PharmaEssentia shall transfer to Kinex all right, title and interest in and Control over all Intellectual Property owned and Controlled of PharmaEssentia and arising from inventions during the Agreement Term as described in
Section 6.1(a) (ii) of this Agreement, (iii) PharmaEssentia shall transfer to Kinex any and all INDs, Regulatory Approvals, Drug Approval Applications and any other regulatory filings or submissions made or filed for Licensed Product
by PhannaEssentia or its designees; and (iv) Kinex shall promptly return to PharmaEssentia all relevant records and materials in Kinex’s possession or control containing Proprietary Information of PharmaEssentia (provided
that Kinex may keep one copy of such Proprietary Information of PharmaEssentia for archival purposes only). 

  
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 ARTICLE 9 

INDEMNIFICATION AND INSURANCE 

9.1 Indemnity. For purposes of this Article 9, “Kinex Indemnified Parties” refers to Kinex, its Affiliates and
the officers, directors, employees, shareholders, agents and successors and assigns of Kinex and its Affiliates, and “PharmaEssentia Indemnified Parties” refers to PharmaEssentia, its Affiliates and officers, directors, employees,
shareholders, agents and successors and assigns of PharmaEssentia and its Affiliates. 
 9.2 PharmaEssentia Indemnification.
PharmaEssentia shall defend the Kinex Indemnified Parties from and against all suits, claims, actions, demands, complaints, lawsuits or other proceedings, (collectively, “Claims”), that are brought by a Third Party, and shall
indemnify and hold harmless to the fullest extent permitted by law the Kinex Indemnified Parties from and against any and all Losses, that arise out of or are attributable to, (i) PharmaEssentia’s negligence, recklessness or willful
misconduct in exercising or performing any of its rights or obligations under this Agreement; or (ii) a material breach by PharmaEssentia of any of its obligations, representations, warranties or covenants under this Agreement; provided,
however, that PharmaEssentia shall not be obligated under this Section 9.2, to the extent it is shown by evidence acceptable in a court of law having jurisdiction over the subject matter and meeting the appropriate degree of proof for
such Claim that the Claim arose out of the negligence or wrongdoing on the part of Kinex. 
 9.3 Kinex Indemnification. Kinex shall
defend the PharmaEssentia Indemnified Parties from and against all Claims, in each case that are brought by a Third Party, and shall indemnify and hold harmless to the fullest extent permitted by law the PharmaEssentia Indemnified Parties from and
against any and all Losses that arise out of such Claims that are attributable to, (i) Kinex’s negligence, recklessness or willful misconduct in exercising or performing any of its rights or obligations under this Agreement; or (ii) a
material breach by 

  
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Kinex of any of its obligations, representations, warranties or covenants under this Agreement; provided, however, that Kinex shall not be obligated under this Section 9.3, to
the extent it is shown by evidence acceptable in a court of law having jurisdiction over the subject matter and meeting the appropriate degree of proof for such Claim that the Claim arose out of the negligence or wrongdoing on the part of
PharmaEssentia. 
 9.4 Indemnification Procedure. 

(a) Each Party shall promptly notify the other Party in writing of any Claim. Concurrent with the provision of notice pursuant to this
Section 9.4(a), the Indemnified Party shall provide to the other Party copies of any complaint, summons, subpoena or other court filings or correspondence related to such Claim and will give such other information with respect thereto as the
other Party shall reasonably request. The Indemnifying Party and Indemnified Party shall meet to discuss how to respond to such Claim. Failure to provide prompt notice shall not relieve any Party of the duty to defend or indemnify unless such
failure materially prejudices the defense of any matter. Each Party agrees that it will take reasonable steps to minimize the burdens of the litigation on witnesses and on the ongoing business of the Indemnified Parties including making reasonable
accommodations to witnesses’ schedules when possible and seeking appropriate protective orders limiting the duration and/or location of depositions. 

(b) Should either Party dispute that any Claim or portion of a Claim (“Disputed Claim”) of which it receives notice pursuant
to Section 9.4(a), is an indemnified Claim, it shall so notify the other Party providing written notice in sufficient time to permit such other Party to retain counsel and timely appear, answer and/or move in any such action. In such event,
such other Party shall defend against such Claim; provided, however, that such other Party shall not settle any Claim which it contends is an indemnified Claim without providing the Indemnifying Party ten (10) Business Days’
notice prior to any such settlement and an opportunity to assume the defense and indemnification of such Claim pursuant to this 

  
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Agreement. If it is determined that a Disputed Claim is subject to indemnification, the Indemnifying Party will reimburse the costs and expenses, including reasonable attorneys’ fees, of the
Indemnified Party. 
 9.5 Settlement of Indemnified Claims. The Indemnifying Party under Sections 9.2 or 9.3, as applicable,
shall have the sole authority to settle any Indemnified Claim without the consent of the other Party, provided, however, that an Indemnifying Party shall not, without the written consent of the other Party, as part of any settlement or
compromise (i) admit to liability on the part of the other Party; (ii) agree to an injunction against the other Party; or (iii) settle any matter in a manner that separately apportions fault to the other Party. The Parties further
agree that as part of the settlement of any Indemnified Claim, an Indemnifying Party shall obtain a full, complete and unconditional release from the claimant on behalf of the Indemnified Parties. 

9.6 Insurance. 
 (a)
PharmaEssentia shall maintain in the Territory, commencing as of the Effective Date, commercial general liability insurance (including coverage for product liability, contractual liability, bodily injury, property damage and personal injury), in
form and substance reasonably satisfactory to the other Party, with minimum limits of $5,000,000 per occurrence or, in case of Clinical Studies, $5,000,000 per occurrence during the period when such Clinical Studies are being conducted (the
“Insurance”). If such Insurance is written on a claims-made form, it shall continue for three (3) years following the last sale of Licensed Product by PharmaEssentia. The Insurance shall have retroactive date to or coinciding
with the Effective Date. Notwithstanding the foregoing, PharmaEssentia may satisfy the foregoing obligation with respect to the Insurance through self-insurance. 

(b) Such Insurance shall insure against all liability arising out of the manufacture, use, sale, distribution, or marketing of Licensed
Product in and for the Territory. 

  
 51 

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 Execution Copy 
  

 
During the Agreement Term, PharmaEssentia shall not permit such Insurance to be reduced, expired, materially amended or canceled during the period of the Insurance and/or the Agreement without
reasonable prior written notice that shall be sent by registered mail to Kinex. Upon request PharmaEssentia shall provide certificates of insurance to Kinex evidencing the coverage specified herein. 

(c) Except as expressly stated herein, a Party’s liability to the other is in no way limited to the extent of the Party’s insurance
coverage. 
 (d) The Insurance shall contain an explicit clause, stating that each Party and its insurer waive their rights of subrogation
against the other Party and its directors, employees and/or any one on its behalf with respect to the Insurance. Such waiver shall not apply in the event of a malicious act. 

(e) The Insurance shall be primary to any other insurance maintained by each Party and each Party hereby waives any claim or demand as to
participation in any such other insurance. 
 (f) The Insurance shall be valid in any location worldwide regarding the activities performed
by each Party hereunder (including worldwide jurisdictions) for any destination or lawsuit which will be served against the other Party. 

9.7 Limitation of Liability. IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER OR ANY OF ITS AFFILIATES FOR ANY CONSEQUENTIAL,
INCIDENTAL, INDIRECT, SPECIAL, PUNITIVE OR EXEMPLARY DAMAGES (INCLUDING LOST PROFITS, BUSINESS OR GOODWILL) SUFFERED OR INCURRED BY SUCH OTHER PARTY OR ITS AFFILIATES, WHETHER BASED UPON A CLAIM OR ACTION OF CONTRACT, WARRANTY, NEGLIGENCE, STRICT
LIABILITY OR OTHER TORT, OR OTHERWISE, ARISING OUT OF THIS AGREEMENT. THE FOREGOING SENTENCE SHALL NOT LIMIT THE OBLIGATIONS OF EITHER PARTY TO INDEMNIFY THE OTHER PARTY FROM AND AGAINST THIRD PARTY CLAIMS UNDER THIS ARTICLE 

  
 52 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 
  

 ARTICLE 10 

MISCELLANEOUS 
 10.1
Force Majeure. Neither Party shall be held liable or responsible to the other Party nor be deemed to have defaulted under or breached the Agreement for failure or delay in fulfilling or performing any term of the Agreement during the period
of time when such failure or delay is caused by or results from events beyond the reasonable control of a Party, including fire, flood, earthquake, explosion, storm, blockage, embargo, war, acts of war (whether war be declared or not), terrorism,
insurrection, riot, civil commotion, strike, lockout or other labor disturbance, failure of public utilities or common carriers, act of God or act, omission or delay in acting by any governmental authority or the other Party. The affected Party
shall notify the other Party of such force majeure circumstances as soon as reasonably practicable. 
 10.2 Assignment. The Agreement
may not be assigned or otherwise transferred without the prior written consent of the other Party; provided, however, that either Party may assign this Agreement to an Affiliate or in connection with the transfer or sale of its
business or all or substantially all of its assets or in the event of a merger, consolidation, change in control or similar corporate transaction, without such consent; provided further, that such assignment shall not relieve the Party
of its responsibilities for performance of its obligations under this Agreement. This Agreement shall be binding upon and inure to the benefit of the successors and permitted assigns of the Parties. Any assignment not in accordance with this
Agreement shall be void. 

  
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 Execution Copy 
  

 10.3 Severability. In the event that any of the provisions contained in this Agreement
are held invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired thereby, unless the absence of the invalidated
provision(s) adversely affects the substantive rights of the Parties. In such event, the Parties covenant and agree to renegotiate any such term, covenant or application thereof in good faith in order to provide a reasonably acceptable alternative
to the term, covenant or condition of this Agreement or the application thereof that is invalid or unenforceable, it being the intent of the Parties that the basic purposes of this Agreement are to be effectuated. 

10.4 Notices. 
 (a)
Correspondence, reports, documentation, and any other communication in writing between the Parties in the course of ordinary implementation of this Agreement (but not including any notice required by this Agreement) shall be in writing and delivered
by hand, sent by email, or by overnight express mail (e.g., FedEx) to any one (1) representative designated by the Party which is to receive such written communication. 

(b) Extraordinary notices and communications (including but not limited to notices of termination, force majeure, material breach, change of
address, or any other notices required by this Agreement) shall be in writing and shall be deemed to have been given when delivered in person, or sent by overnight courier service (e.g., FedEx), postage prepaid, or by facsimile confirmed by
prepaid registered or certified air mail letter or by overnight express mail (e.g., FedEx), or sent by prepaid certified or registered air mail, return receipt requested, to the following addresses of the Parties (or to such other address or
addresses as may be specified from time to time in a written notice), and shall be deemed to have been properly served to the addressee upon receipt of such written communication, to the following addresses of the Parties: 

if to Kinex to: 
 KINEX
PHARMACEUTICALS, LLC 
 701 Ellicott Street 

Buffalo, New York 14203 USA 

Attention: Chief Executive Officer 

Fax No.: 716-849-6651 

  
 54 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 
  

 if to PharmaEssentia to: 

PHARMAESSENTIA CORP 
 13F,
No. 3 YuanQu Street 
 Nankang District, Taipei 115, TAIWAN 

Attention: Chief Executive Officer 

Fax No.: +886-2-2655-7626 
 or to such other
address as the Party to whom notice is to be given may have furnished to the other Parties in writing in accordance herewith. Any such communication shall be deemed to have been given when delivered if personally delivered or sent by facsimile on a
Business Day, upon confirmed delivery by nationally-recognized overnight courier if so delivered, and on the third Business Day following the date of mailing if sent by registered or certified mail. 

10.5 Specific Performance. Each of the Parties acknowledges and agrees that the other Party may suffer irreparable and continuing
damage for which there is no adequate remedy at law in the event of a breach or threatened breach of this Agreement. Accordingly, and 

  
 55 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 
  

 
notwithstanding anything herein to the contrary, each of the Parties agrees that the other Party shall be entitled to seek injunctive relief to prevent breaches of the provisions of this
Agreement, and/or to enforce specifically this Agreement and the terms and provisions hereof, in any action instituted in any court or tribunal having jurisdiction over the Parties and the matter, without posting any bond or other security, and that
such injunctive relief shall be in addition to any other remedies to which such Party may be entitled, at law or in equity. 
 10.6
Further Assurances. Each of the Parties shall take such further actions as shall be necessary or desirable in order to effectuate the respective rights and obligations hereunder. 

10.7 Applicable Law, Venue and Dispute Resolution. This Agreement shall be governed by the laws of the State of New York without regard
to its conflict of laws principles. The United Nations Convention on Contracts for the International Sale of Goods shall not apply in any action, suit or proceeding arising out of or relating to this Agreement. Except as provide in
Section 10.5, with regard to actions of specific performance, all disputes which arise in connection with this Agreement and its interpretation shall be settled amicably between the Parties. If the dispute cannot be settled in an amicable
manner, it will be settled by arbitration to be held in Hong Kong in conformity with commercial arbitration rules of the International Chamber of Commerce. The award rendered by arbitration shall be final and binding upon the Parties hereto. 

10.8 Entire Agreement. This Agreement, including the exhibits and schedules hereto, contains the entire understanding of the Parties
with respect to the subject matter. All express or implied agreements and understandings, either oral or written, heretofore made, including any offering letters, letters of intent, or term sheets, are expressly superseded by this Agreement. This
Agreement may be amended, or any term hereof modified, only by a written instrument duly executed by all Parties hereto. 

  
 56 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 
  

 10.9 Independent Contractors. It is expressly agreed that the Parties shall be
independent contractors and that the relationship between the Parties shall not constitute a partnership, joint venture or agency. Neither Party shall have the authority to make any statements, representations or commitments of any kind, or to take
any action, which shall be binding on the other Party, without the prior consent of such other Party. 
 10.10 Waiver. The waiver by
a Party hereto of any right hereunder or the failure to perform or of a breach by another Party shall not be deemed a waiver of any other right hereunder or of any other breach or failure by said other Party whether of a similar nature or otherwise.

 10.11 Headings; References. The captions to the several Articles and Sections hereof are not a part of the Agreement, but are
merely guides or labels to assist in locating and reading the several Articles and Sections hereof. Any reference in this Agreement to an Article, Exhibit, Schedule or Section shall, unless otherwise specifically provided, be to an Article, Exhibit,
Schedule or Section of this Agreement. The words “including”, “includes” and “such as” are used in their non-limiting sense and have the same meaning as “including without limitation” and “including but
not limited to.” “Hereunder” and “hereto” means under or pursuant to any provision of this Agreement. 
 10.12
Interpretation. Both Parties have had the opportunity to have this Agreement reviewed by an attorney; therefore, neither this Agreement nor any provision hereof shall be construed against the drafter of this Agreement. 

10.13 Counterparts. The Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument. Signatures to the Agreement transmitted by fax, by email in “portable document format” (“.pdf) or by any other electronic means intended to preserve the original graphic and
pictorial appearance of the Agreement shall have the same effect as physical delivery of the paper document bearing an original signature. 

  
 57 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 Execution Copy 
  

 10.14 No Third Party Beneficiaries. Except as specifically set forth herein, none of
the provisions of this Agreement shall be for the benefit of or enforceable by any Third Party, including any creditor of either Party hereto. No such Third Party shall obtain any right under any provision of this Agreement or shall by reasons of
any such provision make any claim in respect of any debt, liability or obligation (or otherwise) against either Party hereto. 

  
 58 

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 Execution Copy 
  

 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first set forth
above. 
  

			
	KINEX PHARMACEUTICALS, LLC
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	PHARMAESSENTIA CORP
		
	By:	 	  

	Name:	 	
	Title:	 	

  
 59 

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

			
	SCHEDULE 1.1	  	SCHEDULE DIAGRAM OF COMPOUND
		
	SCHEDULE 1.2	  	SCHEDULE KINEX PATENT RIGHTS

  

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 SCHEDULE 1.1 

DIAGRAM OF COMPOUNDS 
 *** 

*** 

  

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

 SCHEDULE 1.2 

PATENT RIGHTS 
 Kinex Patent
Chart 
 (August 15, 2011) 
 (1a) 28856-503
(Composition of Matter & Use) 
  

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
 Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	 ***
	 	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***	 	***	 	 	***	 	***
	 ***
	 	***	 	***	 	 		 	***

 (1b) 28856-503CIP (Composition of Matter & Use) 

 

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
Publication

No.
	 	 Comments
	 	 Expected
Expiration

Date

	 ***
	 	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	 		 	***
	 ***
	 	***	 	***	 	***	 	***	 	***	 	 	***	 	***

 (2) 26856-505001 (Method of Synthesis and purity of KX01 and its dichloride salt) 

 

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
 Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***
	***	 	***	 	***	 	***	 	***	 	***	 	 	***	 	***
	***	 	***	 	***	 	 		 	***
	***	 	***	 	***	 	***	 	***	 	***	 		 	***	 	***

 (3) 28856-506002 (Method of Synthesis and purity of mesylate salt of KX01) 

 

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
 Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***
	***	 	***	 	***	 	***	 	***	 	***	 	 	***	 	***
	***	 	***	 	***	 	 		 	***

  

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. 

Continued on Next Page 

  

 Kinex Patent Chart 

(August 15, 2011) 
 (4) 28856-508003 (Polymorph of
pure KX01) 
  

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	***	 	***	 	***	 	***	 	***	 	***
	***	 	***	 	***	 	 	 	***
	***	 	***	 	***	 	 	 	***

 (5) 28856-514 (Dosage of KX01) 
  

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
 Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***	 	***
	***	 	***	 	***	 	***	 	***	 	***	 	 	***	 	***
	***	 	***	 	***	 	 		 	***

 (6) 28856-506 (Dosage of KX02 and immunoprotection) 
  

																	
	 Country

Code
	 	 Country
	 	 Status
	 	 Application

No.
	 	 Application

Data
	 	 National

Entry
 Data
	 	 Related

WIPO
 Publication

No.
	 	 Comments
	 	 Expected

Expiration

Date

	***	 	***	 	***	 	***	 	***	 	***
	***	 	***	 	***	 	 	 	***
	***	 	***	 	***	 	 	 	***

  

	*** =	Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission.EX-10.10.1

 Exhibit 10.10.1 

FIRST AMENDMENT TO LICENSE AGREEMENT 

This FIRST AMENDMENT TO LICENSE AGREEMENT (this “First Amendment”) is made and entered into as of this 23rd day of December,
2016 (“Effective Date”) by and between Athenex, Inc., formerly known as Kinex Pharmaceuticals, LLC, a corporation organized and existing under the laws of the state of Delaware, USA, with a principal place of business at 1001 Main Street,
Suite 600, Buffalo, New York 14203 (“Athenex”), and PharmaEssentia Corp., a publicly traded company organized and existing under the laws of Taiwan with a principal place of business at 13F., No. 3 YuanQu Street, Nankang District,
Taipei 115, Taiwan (“PharmaEssentia”). 
 WITNESSETH: 

WHEREAS, Athenex and PharmaEssentia entered into a License Agreement on December 8, 2011 for the license by Athenex to
PharmaEssentia of rights in the Athenex KX01 and 10(02 Compounds (“License”); 
 WHEREAS, Athenex and PharmaEssentia wish
to amend the terms of the License Agreement to amend the definition of “Field”; 
 NOW, THEREFORE, 

 

	 	1.	All capitalized terms used in this First Amendment and not defined herein shall have the meaning given to them in the License. Except as amended by this First Amendment, the License shall continue in full force and
effect. 

  

	 	2.	The following sentence shall be added to the end of Section 1.24, “Field”: 

“For all countries in the Territory except for Taiwan, Athenex hereby takes back the rights to the dermatologic indication of Actinic
Keratosis and therefore “Field” does not include the dermatologic indication of Actinic Keratosis for any country in the Territory except Taiwan.” 
  

	 	3.	In consideration for this First Amendment, Athenex shall contemporaneously enter into an amendment of a separate and distinct license agreement between Athenex and PharmaEssentia dated December 16, 2013, in the
form as attached hereto as Exhibit “A”. 

  

	 	4.	The parties acknowledge that the non-binding term sheet attached hereto as Exhibit “B” (“Non-Binding Term Sheet”)
forms, in part, the basis for this First Amendment. 

 IN WITNESS WHEREOF, Athenex and PharmaEssentia have executed this First
Amendment as of the date first set forth above. 
  

											
		 	ATHENEX, INC.	 		 	PHARMAESSENTIA CORP.
				
		 	  
	 		 	  

		 	By:	 		 		 	By:	 	
		 	Title:	 		 		 	Title:	 	

 EXHIBIT A 

 FIRST AMENDMENT TO LICENSE AGREEMENT 

This FIRST AMENDMENT TO LICENSE AGREEMENT (this “First Amendment”) is made and entered into as of this 23rd day of December,
2016 (“Effective Date”) by and between Athenex, Inc., formerly known as Kinex Pharmaceuticals, Inc., a corporation organized and existing under the laws of the state of Delaware, USA, with a principal place of business at 1001 Main Street,
Suite 600, Buffalo, New York 14203 (“Athenex”), and PharmaEssentia Corp., a publicly traded company organized and existing under the laws of Taiwan with a principal place of business at 13F., No. 3 YuanQu Street, Nangang District,
Taipei 115, Taiwan (“PharmaEssentia”). 
 WITNESSETH: 

WHEREAS, Athenex and PharmaEssentia entered into a License Agreement on December 16, 2013 for the license by Athenex to
PharmaEssentia of rights in Oraxol and Oratecan (“License”); 
 WHEREAS, Athenex and PharmaEssentia wish to amend the terms
of the License Agreement to amend the definition of “Territory” to add Vietnam and to make other related amendments; 
 NOW,
THEREFORE, 
  

	 	1.	All capitalized terms used in this First Amendment and not defined herein shall have the meaning given to them in the License. Except as amended by this First Amendment, the License shall continue in full force and
effect. 

  

	 	2.	Section 1.67 of the License is amended and restated in its entirety to read as follows: 

“1.67 “Territory” means Taiwan, Singapore and Vietnam. All other countries are expressly excluded and retained by
Athenex.” 
  

	 	3.	A new Section 3.2(1) of the License is added to the License as follows: 

 “(1)
Registration in Vietnam. Notwithstanding any other provision of this License, if PharmaEssentia has not completed a registration submission for Regulatory Approval of any of the Compounds or the Licensed Products in Vietnam by the year 2021
through no fault of Athenex, all rights and clinical data of PharmaEssentia in Vietnam under this License shall be returned to Athenex, except that PharmaEssentia would be permitted to retain one copy of the Clinical Studies data for its use and
purposes in the Territory (for the avoidance of doubt, the Territory of Taiwan and Singapore). Athenex may extend PharmaEssentia’s period for registration under this Section 3.2(1) by one year.” 

 

	 	4.	In consideration for this First Amendment, Athenex shall contemporaneously enter into an amendment of a separate and distinct license agreement between Athenex and PharmaEssentia dated December 8, 2011, in the form
as attached hereto as Exhibit “A”. 

  

	 	5.	The parties acknowledge that the non-binding term sheet attached hereto as Exhibit “B” (“Non-Binding Term Sheet”)
forms, in part, the basis for this First Amendment. 

 IN WITNESS WHEREOF, Athenex and PharmaEssentia have executed this First
Amendment as of the date first set forth above. 
  

											
		 	ATHENEX, INC.	 		 	PHARMAESSENTIA CORP.
				
		 	  
	 		 	  

		 	By:	 		 		 	By:	 	
		 	Title:	 		 		 	Title:	 	

 EXHIBIT B 

 STRICTLY CONFIDENTIAL 

PHARMAESSENTIA NON-BINDING TERM SHEET – 

December 5, 2016 
  

					
	ORAXOL AND ORATECAN VIETNAM RIGHTS - LICENSING TRANSACTION
			
	 OVERVIEW
	 	 -
	  	PharmaEssentia proposes a licensing transaction regarding development and marketing rights of the Oraxol and Oratecan (based on HM30181 as part of the Orascovery program, including IP, all know how and the use of the clinical
studies data) in Vietnam. PharmaEssentia already owns the rights of Taiwan and Singapore from Athenex in a previous transaction.
			
	FIELD	 	-	  	Development and commercialization of the Oraxol and Oratecan for oncology indications.
			
	TERRITORY	 	-	  	Vietnam
			
	LICENSED RIGHTS	 	-	  	A license of the product’s rights and know-how sufficient to enable PharrnaEssentia to develop, label, package, use, import, promote, distribute, offer for sale and sell the Licensed
Product in the Field of use in the Territory as part of the extension of the current existing licensing agreement between Athenex/Kinex and PharmaEssentia on Oraxol and Oratecan.
			
	FINANCIAL TERMS	 	-	  	For the upfront payment, this will consist of
(a) a return of the KX01 and KX02 rights for the dermatologic indication of Actinic Keratosis of their Territory of China and Hong Kong (but PharmaEssentia will keep the Taiwan
Territory) as part of the upfront value contribution
			
		 	-	  	Milestones and Royalty: same as the Agreement between PharmaEssentia and Athenex/Kinex on Oraxol and Oratecan in Taiwan/Singapore
			
		 	-	  	Research and development funding for Taiwan: PharmaEssentia to cover the cost of the studies required for registration in the territory
		
		 	If PharmaEssentia has not completed registration submission in 2021 in Vietnam (with Athenex able to extend the time for one more year) through no fault of Athenex, the product rights and all clinical data in this
territory will be returned to Athenex. However, PharmaEssentia is allowed to retain one copy of the clinical data for the purpose/use solely in the Territory (for the avoidance of doubt, Taiwan and Singapore).
			
	GOVERNANCE	 	-	  	The current Joint Steering Committee (JSC) between the two companies to oversee the development
			
		 	-	  	JSC shall be responsible for the development plan
			
	DEVELOPMENT	 	-	  	PharmaEssentia shall work to create a development plan and budget consistent with regional development requirements
			
	REGULATORY & COMMERCIALIZATION	 	-	  	PharmaEssentia shall have sole responsibility for the commercialization and regulatory filings in the Territory
			
		 	-	  	Athenex shall have sole responsibility for the commercialization and regulatory filings outside the Territories.
			
		 	-	  	The clinical trials that conducted by PharmaEssentia, Athenex or its ex Territory partners shall be made available for referencing for regulatory filings at no cost to either Athenex, PharmaEssentia or its ex Territory partners for
this indication
			
		 	-	  	Athenex and PharmaEssentia shall coordinate their respective regulatory and commercialization efforts to the extent practicable

  
 -1- 

					
			
	TERM	 	-	  	Term shall be the date of patent expiration
			
	TIMING	 	-	  	The parties shall complete the amendment of the licensing agreement with a signing date of no later than December 30, 2016. Amendment of the Oraxol and Oratecan Agreement between Athenex and PharmaEssentia will to add the
Vietnam Territory. Amendment of the KX01 for non-oncology skin indication will be to return the Actinic Keratosis indication back to Athenex.
			
	CONFIDENTIALITY	 	-	  	This term sheet and the contents hereof are subject to the existing confidentiality agreement between the parties
			
		 	-	  	This term sheet does not constitute a legally binding document and does not create any legal obligation on the part of, or any rights in favor of, any parties.

 Accepted: 

PharmaEssentia: Dr. Chingleou Teng, Chairperson of the Board 

Accepted: 
 Athenex: Dr. Johnson Lau,
Chairman and CEO of Athenex 

  
 -2-

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