Document:

Exhibit

Exhibit 4.1

SECOND AMENDMENT TO RIGHTS AGREEMENT

This SECOND AMENDMENT TO RIGHTS AGREEMENT (this “Amendment”) is dated as of March 27, 2018, by and between Spectrum Pharmaceuticals, Inc., a Delaware corporation (the “Company”) and Computershare Trust Company, N.A., a national banking association (the “Rights Agent”), and amends the Rights Agreement, dated as of December 13, 2010, by and between the Company and the Rights Agent (as amended to date, the “Rights Agreement”). Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Rights Agreement. All section and exhibit references herein are to sections and exhibits of the Rights Agreement.

WHEREAS, subject to certain limited exceptions, pursuant to Section 27 of the Rights Agreement, the Company and the Rights Agent may from time to time supplement or amend any provision of the Rights Agreement in accordance with the terms of such Section 27;

WHEREAS, the Board of Directors of the Company has determined to amend the Rights Agreement as set forth herein;

WHEREAS, this Amendment is permitted by Section 27 of the Rights Agreement; and 
WHEREAS, pursuant to Section 27 of the Rights Agreement, the Company hereby directs that the Rights Agreement be amended as set forth in this Amendment.
NOW, THEREFORE, in consideration of the foregoing premises and mutual agreements set forth in this Amendment, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

Section 1.Amendment to Section 7(a).  Section 7(a) of the Rights Agreement is hereby amended and restated in its entirety as follows:
“Subject to Section 7(e) hereof, at any time after the Distribution Date the registered holder of any Rights Certificate may exercise the Rights evidenced thereby (except as otherwise provided herein including, without limitation, the restrictions on exercisability set forth in Section 9(c), Section 11(a)(iii), and Section 23(a) hereof) in whole or in part upon surrender of the Rights Certificate, with the form of election to purchase and the certificate contained therein duly executed, to the Rights Agent at the principal office or offices of the Rights Agent designated for such purpose, together with payment of the aggregate Purchase Price with respect to the total number of one one-thousandths of a Preferred Share (or, following the occurrence of a Triggering Event, Common Shares, other securities, cash, or other assets, as the case may be) as to which such surrendered Rights are then exercisable, at or prior to the earliest of (i) the Close of Business on March 30, 2018 (“Final Expiration Date”), (ii) the time at which the Rights are redeemed as provided in Section 23 hereof, and (iii) the time at which the Rights are exchanged in full as provided in Section 24 hereof (the earliest of (i), (ii), and (iii) being herein referred to as the “Expiration Date”).”

Exhibit 4.1

Section 2.Amendment to Exhibits.
2.1    Exhibit B to the Rights Agreement is amended by deleting each reference to “December 13, 2020” in the Form of Rights Certificate and substituting therefor “March 30, 2018”.
2.2    Exhibit C to the Rights Agreement is amended by deleting each reference to “December 13, 2020” in the Form of Summary of Rights to Purchase Preferred Stock and substituting therefor “March 30, 2018”.
Section 3.    Benefits of the Rights Agreement.  Nothing in the Rights Agreement, as amended by this Amendment, shall be construed to give to any Person other than the Company, the Rights Agent, and the registered holders of the Rights Certificates (and, prior to the Distribution Date, of the Common Shares) any legal or equitable right, remedy, or claim under the Rights Agreement, as amended by this Amendment; but the Rights Agreement, as amended by this Amendment, shall be for the sole and exclusive benefit of the Company, the Rights Agent, and the registered holders of the Rights Certificates (and, prior to the Distribution Date, of the Common Shares).
Section 4.    Severability.  The terms, provisions, covenants or restrictions (or parts thereof) of this Amendment shall be deemed severable and the invalidity or unenforceability of any term, provision, covenant or restriction (or part thereof) shall not affect the validity or enforceability of the other term, provision, covenant or restriction (or part thereof) of this Amendment.  If any term, provision, covenant or restriction (or part thereof) of this Amendment, or the application thereof to any person or any circumstance, is invalid or unenforceable, (a) a suitable and equitable term, provision, covenant or restriction shall be substituted therefor in order to carry out, so far as may be valid and enforceable, the intent and purpose of such invalid or unenforceable term, provision, covenant or restriction (or part thereof) and (b) the remainder of this Amendment and the application of such term, provision, covenant or restriction (or part thereof) to other Persons or circumstances shall not be affected by such invalidity or unenforceability, nor shall such invalidity or unenforceability affect the validity or enforceability of such term, provision, covenant or restriction (or part thereof), or the application thereof, in any other jurisdiction.
Section 5.    Governing Law.  This Amendment shall be deemed to be a contract made under the laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the laws of such State applicable to contracts made and to be performed entirely within such State.
Section 6.    Effective Date; Certification. This Amendment shall be deemed effective as of the date first written above, as if executed on such date.  The officer of the Company executing this Amendment hereby certifies to the Rights Agent that the amendment to the Rights Agreement set forth in this Amendment is in compliance with Section 27 of the Rights Agreement and the certification contained in this Section 6 shall constitute the certification required by Section 27 of the Rights Agreement.
Section 7.    No Other Effect.  Except as expressly set forth herein, the Rights Agreement shall not by implication or otherwise be supplemented or amended by virtue of this Amendment, but shall remain in full force and effect, as amended hereby.
Section 8.    Notice.  The Rights Agent and the Company hereby waive any notice requirement with respect to each other under the Rights Agreement, if any, pertaining to the matters covered by this Amendment.

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Exhibit 4.1

Section 9.    Counterparts.  This Amendment may be executed in any number of counterparts and each of such counterparts shall for all purposes be deemed to be an original, and all such counterparts shall together constitute but one and the same instrument.  A facsimile or .pdf signature delivered electronically shall constitute an original signature for all purposes.
[Signature Page Follows]

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Exhibit 4.1

IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the date first written above.

	
		
	SPECTRUM PHARMACEUTICALS, INC.

	 
	 

	By:
	/s/ Kurt A. Gustafson

	Name:
	Kurt A. Gustafson

	Title:
	EVP & Chief Financial Officer

	 
	 

	 
	 

	 
	 

	COMPUTERSHARE TRUST COMPANY, N.A.,

	as Rights Agent

	 
	 

	By:
	/s/ Dennis V. Moccia

	Name:
	Dennis V. Moccia

	Title:
	Manager, Contract Administration

SIGNATURE PAGE TO SECOND AMENDMENT TO RIGHTS AGREEMENTEX-10.2

 Exhibit 10.2 

AMENDMENT 
 TO SALE AND
SERVICING AGREEMENTS 
 This AMENDMENT TO SALE AND SERVICING AGREEMENTS, dated as of March 27, 2018 (this
“Amendment”), is by and between NISSAN AUTO RECEIVABLES CORPORATION II, a Delaware corporation (the “Seller”) and NISSAN MOTOR ACCEPTANCE CORPORATION (“NMAC”), a California corporation, as Servicer
(in such capacity, the “Servicer,” and together with the Seller, the “Parties”). 
 RECITALS: 

WHEREAS, separate and discrete Delaware statutory trust issuers (each, an “Issuer,” collectively, the
“Issuers”), certain indenture trustees (each as identified on Schedule A to this Amendment, an “Indenture Trustee”), the Seller, the Servicer and NMAC, in its individual capacity, have entered into Sale and
Servicing Agreements for each of the transactions listed on Schedule A to this Amendment (collectively the “Sale and Servicing Agreements”); 

WHEREAS, the Parties desire to amend Section 5.02(a) of each of the Sale and Servicing Agreements to modify the requirements of
the Monthly Remittance Condition (as such term is defined therein); and 
 WHEREAS, the Parties desire to implement such amendments
as of the Effective Date (as defined below) in accordance with the terms and conditions set forth below pursuant to Section 10.01(a) of each of the Sale and Servicing Agreements. 

NOW, THEREFORE, in consideration of the mutual agreements herein contained and other good and valuable consideration, receipt of which
is acknowledged, the Parties hereto agree as follows: 
 ARTICLE I 

RECITALS AND DEFINITIONS 

Section 1.1 Definitions. Capitalized terms used and not defined herein have the respective meanings assigned such
terms in the applicable Sale and Servicing Agreement. 
 ARTICLE II 

AMENDMENTS 

Section 2.1 Amendments to Group A Sale and Servicing Agreements. As of the Effective Date, the third sentence of
Section 5.02(a) of each Sale and Servicing Agreement for a Group A transaction (as identified in Schedule A) is hereby amended to replace the reference to “F1” therein with “F2”. 

Section 2.2 Amendments to Group B Sale and Servicing Agreements. As of the Effective Date, the second sentence of
Section 5.02(a) of each Sale and Servicing Agreement for a Group B transaction (as identified in Schedule A) is hereby amended to replace the reference to “F1” therein with “F2”. 

  

					
	 	 	 	 	 Amendment to

Sale and Servicing Agreements

 Section 2.3 Amendment to Group C Sale and Servicing Agreement. As of the
Effective Date, the second sentence of Section 5.02(a) of the Sale and Servicing Agreement for the Group C transaction (as identified in Schedule A) is hereby amended and restated in full to read as follows: 

“The “Monthly Remittance Condition” shall be deemed to be satisfied if (i) NMAC is the Servicer and
(ii) NMAC’s short-term unsecured debt obligations are rated at least “P-1” by Moody’s and at least “F2” by Fitch (so long as Moody’s and Fitch are Rating
Agencies).” 
 ARTICLE III 

EFFECTIVE DATE 

Section 3.1 Effective Date. Upon satisfaction of the following conditions this Amendment shall become effective
immediately (such date, the “Effective Date”) without further action by any Party: 
 (a) receipt by the Servicer of an
executed counterpart of this Amendment from each Party hereto; 
 (b) satisfaction of the Rating Agency Condition with respect to this
Amendment in accordance with Section 10.01(a)(ii) of each Sale and Servicing Agreement; and 
 (c) receipt by the Owner Trustee and
each Indenture Trustee of an Opinion of Counsel, as required pursuant to Section 10.01(d) of each Sale and Servicing Agreement, stating that the execution of such amendment is authorized or permitted by such Sale and Servicing Agreements. 

ARTICLE IV 

MISCELLANEOUS 

Section 4.1 Sale and Servicing Agreements Unaffected. Except as modified herein, the Parties acknowledge that the
provisions of each of the Sale and Servicing Agreements remain in full force and effect and are hereby ratified and confirmed by the Parties hereto. After the Effective Date all references in the applicable Basic Documents to a Sale and Servicing
Agreement shall mean such Sale and Servicing Agreement as modified hereby. 
 Section 4.2 Governing Law. This
Amendment shall be construed in accordance with the laws of the State of New York, without reference to its conflict of law provisions (other than Section 5-1401 of the General Obligations Law of the
State of New York), and the obligations, rights and remedies of the Parties hereunder shall be determined in accordance with such laws. 

  

					
	 	 	2	 	 Amendment to

Sale and Servicing Agreements

 Section 4.3 Captions. The various captions in this Amendment are
included for convenience only and shall not affect the meaning or interpretation of any provision of this Amendment or any provision hereof. 

Section 4.4 Severability. Whenever possible, each provision of this Amendment shall be interpreted in such manner as
to be effective and valid under applicable law, but if any provision of this Amendment shall be prohibited by or invalid under the laws of any applicable jurisdiction, such provision, as to jurisdiction, shall be ineffective to the extent of such
prohibition or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Amendment as to such jurisdiction or any other jurisdiction. 

Section 4.5 Binding Effect. This Amendment shall be binding upon and inure to the benefit of the parties hereto and
their respective successors and assigns. 
 Section 4.6 Counterparts. This Amendment may be executed in any number
of counterparts and by the parties hereto on separate signature pages, each such executed counterpart constituting an original but all together only one Amendment. 

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed and delivered as of the date first above written. 

 

			
	NISSAN AUTO RECEIVABLES CORPORATION II, as Seller
		
	By:	 	/s/ Riley A. McAndrews
	Name: Riley A. McAndrews
	Title:   Assistant Treasurer
	
	NISSAN MOTOR ACCEPTANCE CORPORATION, Servicer
		
	By:	 	/s/ Riley A. McAndrews
	Name: Riley A. McAndrews
	Title:   Assistant Treasurer

  

					
	 	 	3	 	 Amendment to

Sale and Servicing Agreements

 SCHEDULE A 

Group A: 
  

	 	        1.	    Nissan Auto Receivables Owner Trust Series 2013-C 

i.   Indenture Trustee: U.S. Bank National Association 

 

	 	        2.	    Nissan Auto Receivables Owner Trust Series 2014-A 

i.   Indenture Trustee: Citibank, N.A. 
  

	 	        3.	    Nissan Auto Receivables Owner Trust Series 2014-B 

i.   Indenture Trustee: Wells Fargo Bank, National Association 

 

	 	        4.	    Nissan Auto Receivables Owner Trust Series 2015-A 

i.   Indenture Trustee: Wells Fargo Bank, National Association 

 

	 	        5.	    Nissan Auto Receivables Owner Trust Series 2015-B 

i.   Indenture Trustee: U.S. Bank National Association 

 

	 	        6.	    Nissan Auto Receivables Owner Trust Series 2015-C 

i.   Indenture Trustee: U.S. Bank National Association 

Group B: 
  

	 	        7.	    Nissan Auto Receivables Owner Trust Series 2016-A 

i.   Indenture Trustee: U.S. Bank National Association 

 

	 	        8.	    Nissan Auto Receivables Owner Trust Series 2016-B 

i. Indenture Trustee: U.S. Bank National Association 
  

	 	        9.	    Nissan Auto Receivables Owner Trust Series 2016-C 

i.   Indenture Trustee: U.S. Bank National Association 

 

	 	        10.	    Nissan Auto Receivables Owner Trust Series 2017-A 

i.   Indenture Trustee: U.S. Bank National Association 

 

	 	        11.	    Nissan Auto Receivables Owner Trust Series 2017-B 

i.   Indenture Trustee: U.S. Bank National Association 

Group C: 
  

	 	        12.	    Nissan Auto Receivables Owner Trust Series 2017-C 

i.   Indenture Trustee: U.S. Bank National Association 

  

					
	 	 	4	 	 Amendment to

Sale and Servicing Agreements

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