Document:

Exhibit 10.10

     

  	
          womblebonddickinson.com

        	

   

  1 July 2019

   

  Deed Of Variation

  Relating To

  Lease of Suite 8, First Floor, The Queen Mary Bioenterprises Innovation 

  Centre, 42 New Road, London 

   

  Queen Mary Bioenterprises Limited (1) and

  ADC Therapeutics (UK) Limited (2)

   

  Womble Bond Dickinson (UK) LLP

  Tel+44(0)345 415 0000

  www.womblebonddickinson.com

   

  
    
      
 

  

  CONTENTS

   

  	Clause	Page
	 	 	 
	1.	INTERPRETATION	1
	2.	VARIATIONS TO THE LEASE	2
	3.	TENANT’S COVENANT	2
	4.	ENDORSEMENT	2
	5.	GOVERNING LAW	2
	6.	JURISDICTION	2
	7.	THIRD PARTY RIGHTS	2
	SCHEDULE 1	3
	 	Variations to the Lease	3

   

  
    
      
 

  

  
  PARTIES 

   

  		(1)	Queen Mary Bioenterprises Limited incorporated and registered in England and Wales with company number 04324033 whose registered office is at Queen
          Mary University of London, 327 Mile End Road, London, E1 4NS (Landlord).

   

  		(2)	ADC Therapeutics (UK) Limited incorporated and registered in England and Wales with company number 09353055 whose registered office is at 4th Floor, Reading Bridge House, George Street, Reading, Berkshire, RG1 8LS (Tenant).

   

  BACKGROUND

   

  	(A)	This deed is supplemental and collateral to the Lease.

   

  	(B)	The Landlord and the Tenant have agreed to vary the Lease on the terms set out in this deed. 

   

  	(C)	The Landlord is entitled to the immediate reversion to the Lease.

   

  	(D)	The residue of the term granted by the Lease is vested in the Tenant.

   

  AGREED TERMS 

   

  	1.	INTERPRETATION 

   

  The following definitions and rules of interpretation apply in this deed.

   

  	1.1	Definitions:

   

  	 	Lease	a lease of the Property dated 9 July 2018 and made between (1) Queen Mary Bioenterprises Limited and (2) ADC Therapeutics (UK) Limited.
	 	 	 
	 	Property	Suite 8, First Floor of the Queen Mary Bioenterprises Innovation Centre as more particularly described in and demised by the Lease.

   

  	1.2	References to the Landlord include a reference to the person entitled for the time being to the immediate reversion to the Lease. References to the Tenant
          include a reference to its respective successors in title and assigns.

   

  	1.3	A reference to the Lease includes any deed, licence, consent, approval or other instrument supplemental to it.

   

  	1.4	A reference to a statute or statutory provision is a reference to it as amended, extended or re-enacted from time to time.

   

  	1.5	A reference to a statute or statutory provision shall include all subordinate legislation made from time to time under that statute or statutory provision.

   

  	1.6	A person includes a natural person, corporate or unincorporated body (whether or not having separate legal personality).

   

  	1.7	The expression tenant covenant has the meaning given to it by the Landlord and Tenant (Covenants) Act 1995.

   

  	1.8	Unless the context otherwise requires, words in the singular shall include the plural and in the plural shall include the singular.

   

  
    1

    
      
 

  

  	1.9	Unless the context otherwise requires, a reference to the Property is to the whole and any part of it.

   

  	1.10	Except where a contrary intention appears, references to clauses and Schedules are to the clauses and Schedules of this deed and references to paragraphs are
          to paragraphs of the relevant Schedule.

   

  	1.11	Clause, Schedule and paragraph headings shall not affect the interpretation of this deed.

   

  	1.12	Except to the extent that they are inconsistent with the definitions and interpretations in Clause 1 of this deed, the definitions and interpretations in
          clause 1 of the Lease shall apply to this deed.

   

  	2.	VARIATIONS TO THE LEASE 

   

  	2.1	Variations made

   

  		From and including the date of this deed, the Lease shall be read and construed as varied by the provisions set out in the Schedule.

   

  	2.2	Lease remains in force

   

  		The Lease shall remain fully effective as varied by this deed and the terms of the Lease shall have effect as though the provisions contained in this deed
          had been originally contained in the Lease.

   

  	3.	TENANT’S COVENANT

   

  The Tenant covenants to observe and perform the tenant’s covenants in the Lease as varied by this deed.

   

  	4.	ENDORSEMENT

   

  Promptly following completion of this deed both the Landlord and the Tenant shall each endorse a memorandum of variation upon the Lease and its counterpart
    in the following terms:

   

  “This Lease has been varied by a Deed of Variation dated [                    ] 2019 and made between (1) Queen Mary Bioenterprises Limited and (2) ADC
    Therapeutics (UK) Limited.

   

  	5.	GOVERNING LAW

   

  This deed and any dispute or claim arising out of or in connection with it or its subject matter or formation (including non-contractual disputes or claims)
    shall be governed by and construed in accordance with the law of England and Wales.

   

  	6.	JURISDICTION 

   

  Each party irrevocably agrees that the courts of England and Wales shall have exclusive jurisdiction to settle any dispute or claim arising out of or in
    connection with this deed or its subject matter or formation (including non-contractual disputes or claims).

   

  	7.	THIRD PARTY RIGHTS 

   

  A person who is not a party to this deed shall not have any rights under the Contracts (Rights of Third Parties) Act 1999 to enforce any term of this deed.
    This does not affect any right or remedy of a third party which exists or is available apart from that Act.

   

  This Deed has been entered into on the date stated at the beginning of it. 

  
    2

    
      
 

  

  SCHEDULE 1

   

  Variations to the Lease

   

  REPLACEMENT OF EXISTING DEFINITIONS

   

  The definition of “Break Date” shall be deleted and replaced with the following:-

   

  “Break Date” 1 July 2020 and 1 January 2022

  

  

  
    3

    
      
 

  

  
    	
            Executed as a deed by Queen Mary Bioenterprises

          	 
	
            Limited acting by a director and its secretary

          	
            Director  /s/ [Illegible]

          
	 	
            

            

          
	 	
            Director/Secretary  /s/ R. Richmond

          

  

  

  

  
    4

    
      
 

  

  
  
    	
            Executed as a deed by ADC Therapeutics (UK)

          	 
	
            Limited acting by a director and its secretary

          	
            Director  /s/ Michael Forer

          
	 	
            

            

          
	 	
            Director/Secretary 

            

          

  

   

  5Exhibit 10.11

    

     

    

    
      FORM OF INDEMNITY AGREEMENT

       

      

      made as of [Date]

       

      

      between

       

      

      ADC Therapeutics SA

       

      

      Biopôle

        Route de la Corniche 3B

        1066 Epalinges

        Switzerland

      (the “Company”)

      

      

      and

      

      

      [Covered Person]

       

      

      [Address]

      (the “Covered Person”)

       

      

      (collectively the “Parties”)

      
        
          

      

      
      PREAMBLE

       

      

      WHEREAS

       

      

      
        	
                A.

              	
                The Covered Person has been elected as a member of the Board of Directors (a “Director”) or appointed as member of the management (an “Officer”) of ADC Therapeutics SA, a company constituted under the laws of Switzerland, having its corporate seat in Epalinges. For the avoidance of doubt, for purposes of this agreement, the functions
                  and activities or omissions of the Covered Person as a member of a committee of the Board of Directors shall also be deemed functions, activities or omissions of such Covered Person as a Director.

              

      

      
         

        

        	
                B.

              	
                ADC Therapeutics SA is a biotechnology company, and its shares are listed on the New York Stock Exchange in the United States.

              

      

      
         

        

        	
                C.

              	
                The Covered Person is exposed to litigation risks arising from claims that may be brought against him or her in connection with his or her function as a Director or Officer.

              

      

      
         

        

        	
                D.

              	
                The articles of association of the Company (“Articles of Association”) provide that the Company shall indemnify and advance expenses to all
                  Directors and Officers in the manner set forth therein and to the fullest extent permitted by applicable law.

              

      

      
         

        

        	
                E.

              	
                It is reasonable, prudent and necessary for the Company, in due consideration of the risks related to its activity and its position as a US stock-exchange listed company, to enter
                  into this indemnity agreement (the “Agreement”) to contractually indemnify persons serving as Directors or Officers to the fullest extent permitted by the Articles of Association of the Company and
                  the applicable law so that they will serve, or continue to  serve, in such capacity free from undue concern that they will not be so indemnified.

              

      

       

      

      NOW, THEREFORE, the Company and the Covered Person hereby agree as follows:

      
         

        

        	
                1.

              	
                THIRD PARTY PROCEEDINGS

              

      

      
         

        

        	
                1.1

              	
                In connection with any threatened, pending or completed action, suit or proceeding, whether civil, criminal or administrative, to which he or she was, is or is threatened to be made
                  a party, or is otherwise involved, whether conducted by the Company or any other party, whether civil, criminal, administrative, investigative or other and whether formal or informal except for one initiated by the Covered Person to
                  enforce the Covered Person’s rights under the Agreement (a “Proceeding”) involving the Covered Person, the Company shall indemnify the Covered Person if:

              

      

      
         

        

        	
                a)

              	
                he or she was or is a party or is threatened to be made a party to any Proceeding by reason of the fact that he or she is or was a Director or an Officer or a member of the Board of
                  Directors or management of a direct or indirect subsidiary of the Company (an “Affiliate”); and

              

      

      
         

        

        	
                b)

              	
                he or she is a party or is threatened to be made a party to any Proceeding by reason of the fact that he or she is or was an employee, agent or consultant of the Company or an
                  Affiliate, or is or was serving at the request of the Company as a Director or Officer,

              

      

       

      

      against any expenses, including reasonable attorneys’ fees, court and administrative fees, related taxes and obligations of any nature whatsoever actually and reasonably
        incurred by him or her in any Proceeding, including judgments, damages, fines, other liability or claims, and amounts paid in connection with a settlement incurred by the Covered Person in connection with such Proceeding (the “Expenses”).

       

      

      
        	
                1.2

              	
                Any indemnification under this Agreement, other than advance payments (unless ordered by a court), shall be made by the Company only as authorized in the specific case upon a
                  determination that indemnification of the Covered Person is not excluded pursuant to Section 3.

              

      

      
         

        

        	
                2.

              	
                PROCEEDING IN THE RIGHT OF THE COMPANY

              

      

      
         

        

        	
                2.1

              	
                The Company shall indemnify the Covered Person against any Expenses if the Covered Person was or is a party or is threatened to be made a party to any Proceeding by or in the right
                  of the Company to procure a judgment in favor of the Company by reason of the fact that the Covered Person is or was a Director, Officer, employee, consultant or agent of the Company or its Affiliates or is or was serving at the request
                  of the Company as a Director, Officer, employee, consultant or agent of, or participant in, another corporation, partnership, joint venture, trust, or other enterprise.

              

      

      
        
          2

          
            

        

        	
                2.2

              	
                As far as is permissible under applicable law, Expenses incurred in defending any Proceeding for which indemnification is permitted pursuant to this Agreement shall be paid by the
                  Company in advance of the final disposition of such proceeding upon receipt by the Board of Directors of an undertaking by or on behalf of the Covered Person to repay such amount if it shall ultimately be determined that he or she is not
                  entitled to be indemnified by the Company under this Agreement.

              

      

      
         

        

        	
                3.

              	
                NO INDEMNIFICATION

              

      

      
         

        

        	
                3.1

              	
                Section 1 and 2 above shall not apply, and any advanced Expenses shall be reimbursed by the Covered Person to the Company if:

              

      

      
         

        

        	
                a)

              	
                a competent court holds the Covered Person to be liable and concludes that the relevant actions or omissions giving rise to the Proceeding constitute fraud, dishonesty or an
                  intentional or grossly negligent breach of the duties of the Covered Person under applicable law or under his terms of office or agreements with the Company including the obligation to act honestly and in good faith with a view to the
                  best interests of the Company; or

              

      

      
         

        

        	
                b)

              	
                absent a judgment by a competent court as set forth under Section 3.1(a) above, it is prima facie apparent that the relevant actions or omissions giving rise to the Proceeding
                  constitute fraud, dishonesty or an intentional or grossly negligent breach of the duties of the Covered Person under applicable law or under his terms of office or agreements with the Company.

              

      

      
         

        

        	
                3.2

              	
                Any determination shall be made, with respect to a Covered Person:

              

      

      
         

        

        	
                a)

              	
                by a majority vote of the members of the Board of Directors who are not parties to such proceeding, even though less than a quorum; or

              

      

      
         

        

        	
                b)

              	
                by a committee of members of the Board of Directors designated by a majority vote of the members of the Board of Directors who are not parties to such proceeding, even though less
                  than a quorum; or

              

      

      
         

        

        	
                c)

              	
                if there are no such member of the Board of Directors, or if such member of the Board of Directors so direct, by independent legal counsel in a written opinion; or

              

      

      
         

        

        	
                d)

              	
                by the General Meeting of Shareholders.

              

      

       

      

      To the extent that any Covered Person has been successful on the merits or otherwise in defense of any proceeding, or in defense of any claim, issue or matter therein, such
        Covered Person shall be indemnified against Expenses irrespective of any such prior determination.

      
         

        

        	
                3.3

              	
                Notwithstanding the preceding sentence, this section shall not extend to any person holding the office of auditor or special auditor of the Company.

              

      

      
         

        

        	
                4.

              	
                NON-EXCLUSIVITY

              

      

      
         

        

        	
                4.1

              	
                The Agreement shall supplement the Covered Person’s terms of office and/or employment agreement with the Company as separately agreed with the Company.

              

      

      
         

        

        	
                4.2

              	
                The Agreement shall not limit the Covered Person’s reimbursement rights provided under statutory law and the Articles of Association.

              

      

      
         

        

        	
                5.

              	
                INDEMNIFICATION PROCEDURE

              

      

      
         

        

        	
                5.1

              	
                Should the Covered Person become aware of any Proceeding which could give rise to any entitlements under the Agreement, the Covered Person shall:

              

      

      
         

        

        	
                a)

              	
                as promptly as practicable (but in no event later than 20 business days of becoming so aware), notify the Company in writing of the existence of such a Proceeding, giving, as
                  reasonably available at the time of such notice, reasonable details relating to the Proceeding, including the person(s) making (or threatening to make) the respective Proceeding, the circumstances leading to such a Proceeding, the cause
                  of action for the Proceeding and the possible costs associated with the Proceeding;

              

      

      
        
          3

          
            

        

        	
                b)

              	
                give to the Company and its professional advisers information and access to documents and records as the Company may reasonably request, except where such access would result in a
                  loss of privilege, or would be adverse to the Covered Person’s interests or where the Covered Person is prevented by law from providing such access. In this connection, the Company shall be entitled to require the Covered Person to take
                  such actions and give such information and assistance in order to avoid, mitigate, settle or defend the Proceeding as the Company may reasonably request;

              

      

      
         

        

        	
                c)

              	
                allow the Company upon its request, and following regular consultation with the Covered Person, to conduct such actions as the Company may deem appropriate in connection with any
                  such Proceeding (including assuming the defense of such Proceeding). In this connection, the Covered Person shall give to the Company all assistance as the Company may reasonably require in the conduct of such actions (except in cases
                  where taking such action is adverse to his legitimate and personal interests);

              

      

      
         

        

        	
                d)

              	
                make no admission of liability or enter into settlement discussions with any person in relation to any Proceeding without the prior written consent of the Company (which shall not
                  be unreasonably withheld); and

              

      

      
         

        

        	
                e)

              	
                take all reasonable actions to mitigate any potential loss which may incur as a result of a Proceeding.

              

      

      
         

        

        	
                5.2

              	
                The Company shall be entitled to settle any Proceeding at its sole discretion and without the Covered Person’s prior written consent, except where the terms of the settlement would
                  (i) impose any costs, expense, loss liability, damage, penalty or limitation on the Covered Person or (ii) cause damage to the Covered Person’s image or reputation. In each case of (i) and (ii) above, the Company may settle such
                  Proceeding, provided that the Company obtains the Covered Person’s prior written consent, which the Covered Person shall not unreasonably delay or withhold. In all cases, the Company shall not settle any Proceeding before notifying the
                  Covered Person of its intention and consulting with the Covered Person as to the terms of the proposed settlement. The Covered Person and the Company shall take all actions as may be necessary or advisable to effect such a settlement.

              

      

      
         

        

        	
                5.3

              	
                Notwithstanding the foregoing, the Covered Person and the Company shall take all actions as may be required to comply with the terms of any policy of a directors’ and officers’
                  liability insurance pursuant to Section 6.

              

      

      
         

        

        	
                5.4

              	
                Notwithstanding any provision of the Agreement to the contrary, and subject to reimbursement pursuant to Section 3, the Company shall advance to the Covered Person or pay directly,
                  at the Company’s sole discretion, any Expenses actually and reasonably incurred by the Covered Person in connection with any Proceeding pursuant to Section 1 and 2 of the Agreement within 30 calendar days after the receipt by the Company
                  of each statement requesting such advance from time to time, whether prior to or after final disposition of any Proceeding. Advances shall be unsecured and interest free.

              

      

      
         

        

        	
                6.

              	
                LIABILITY INSURANCE

              

      

      
         

        

        	
                6.1

              	
                To the extent the Company maintains an insurance policy or policies providing directors’ and officers’ liability insurance, the Covered Person shall be covered by such policy or
                  policies in accordance with its or their terms to the maximum extent of the coverage in place for any Director or Officer.

              

      

      
         

        

        	
                6.2

              	
                If, at the time the Company receives notice from any source of a Proceeding to which the Covered Person is a party or a participant (as a witness or otherwise), the Company has
                  director and officer liability insurance in effect, the Company shall give prompt notice of such proceeding to the insurers in accordance with the procedures set forth in the respective policies. The Company shall thereafter take all 
                  necessary or desirable action to cause such insurers to pay, on behalf of the Covered Person, all amounts payable as a result of such Proceeding in accordance with the terms of such policies.

              

      

      
         

        

        	
                6.3

              	
                The Company shall indemnify the Covered Person for Expenses incurred by Covered Person in connection with any reasonable action brought by Covered Person for recovery under any
                  insurance policy referred to in this Section 6 and shall advance to the Covered Person any Expenses actually and reasonably incurred by the Covered Person in connection with such action.

              

      

      
         

        

        	
                7.

              	
                SUBROGATION

              

      

      
         

        

        	
                7.1

              	
                In the event of payment under the Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of the Covered Person, who shall execute
                  all papers required and shall do everything that may be necessary to secure such rights, including the execution of such documents necessary to enable the Company effectively to bring suit to enforce such rights.

              

      

      
        
          4

          
            

        

        	
                8.

              	
                NO DUPLICATION OF PAYMENTS

              

      

      
         

        

        	
                8.1

              	
                The Company shall not be liable under the Agreement to make any payment in connection with any Proceeding made against the Covered Person to the extent the Covered Person has
                  otherwise actually received payment (under an insurance policy or otherwise) of the amounts otherwise indemnifiable hereunder.

              

      

      
         

        

        	
                9.

              	
                EFFECT OF TERMINATION OF SERVICE

              

      

      
         

        

        	
                9.1

              	
                The indemnification provided by this Agreement shall continue for any person who has ceased to be a Covered Person.

              

      

      
         

        

        	
                10.

              	
                BINDING EFFECT

              

      

      
         

        

        	
                10.1

              	
                The Agreement shall be binding upon and inure to the benefit of and be enforceable by the Parties hereto and their respective successors, assigns, including any direct or indirect
                  successor by purchase, merger, amalgamation, consolidation or otherwise to all or substantially all of the business or assets of the Company, spouse, heirs, and personal and legal representatives. The Agreement shall continue in effect
                  regardless of whether Covered Person continues to serve as a Director or Officer of the Company or of any other legal entity at the Board of Directors’ request.

              

      

      
         

        

        	
                10.2

              	
                The obligations of the Company under this Agreement are subject to applicable laws and the Articles of Association.

              

      

      
         

        

        	
                11.

              	
                AMENDMENTS

              

      

      
         

        

        	
                11.1

              	
                The Agreement may only be modified or amended by a document signed by all Parties. Any provision contained in the Agreement may only be waived by a document signed by the party
                  waiving such provision.

              

      

      
         

        

        	
                12.

              	
                SEVERABILITY

              

      

      
         

        

        	
                12.1

              	
                If any part or provision of the Agreement or the application of any such part or provision to any person or circumstance shall be held to be invalid, illegal or unenforceable on any
                  respect by any competent arbitral tribunal, court, governmental or administrative authority, (a) such invalidity, illegality or unenforceability shall not affect any other part or provision of the Agreement or the application of such part
                  or provision to any other person or circumstances, and (b) the Parties shall endeavor to negotiate a substitute provision that best reflects the economic intentions of the Parties without being invalid, illegal or unenforceable, and shall
                  execute all agreements and documents required in this connection.

              

      

      
         

        

        	
                13.

              	
                APPLICABLE LAW AND JURISDICTION

              

      

      
         

        

        	
                13.1

              	
                The Agreement shall be governed by and construed in accordance with the substantive laws of Switzerland, excluding the provisions on conflict-of-laws.

              

      

      
         

        

        	
                13.2

              	
                All disputes arising out of or in connection with the Agreement, including disputes on its conclusion, binding effect, amendment and termination, shall be resolved exclusively by
                  the courts at the domicile of the Company.

              

      

      
        5

        
          

      

      SIGNATURES

      

      

      	
              ADC Therapeutics SA

            	 
	 	 	 
	
              By:

            	 	 
	 	
              Name:

            	 
	 	
              Title:

            	 

      

      

      

      

      

      

      

      

      

      

      	
              [Covered Person]

            	 
	 	 	 
	
              By:

            	 	 
	 	
              Name:

            	 
	 	
              Title:

            	 

       

      

      
        

    

  

  6

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