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                                                                 EXHIBIT 10.22.a
                            FIRST AMENDMENT TO LEASE

         The First Amendment (the "FIRST AMENDMENT") to Lease is made as of July
21, 2000, by and between ARE-708 QUINCE ORCHARD, LLC, a Delaware limited
liability company (hereinafter called "LANDLORD") and GENE LOGIC INC., a
Delaware corporation (hereinafter called "TENANT").

                                    RECITALS

         A.       Landlord and Tenant have entered into that certain Lease (the
"LEASE") dated as of August 22, 1997 (the "LEASE"), wherein Landlord leased to
Tenant certain premises (the "PREMISES") located at 708 Quince Orchard Road,
Gaithersburg, Maryland 20878, and more particularly described in the Lease.

         B.       In connection with the negotiation of a lease by and between
Tenant and an affiliate of Landlord, Landlord and Tenant have agreed to amend
the Lease to provide to Tenant an option, on the conditions described herein, to
relocate from the Premises to other space which may, in Landlord's sole option,
be provided by Landlord or any affiliate of Landlord (the "RELOCATION RIGHT").

         C.       Landlord and Tenant desire to amend the Lease to, among other
things, add the Relocation Right to the Lease.

                                    AGREEMENT

         Now, therefore, the parties hereto agree that the Lease is amended as
follows:

         1.       RELOCATION RIGHT.

         (a)      RELOCATION OF THE PREMISES. Commencing as of the date hereof,
Tenant may at any time give Landlord notice that Tenant desires to lease not
less than 80,000 rentable square feet of laboratory and office space in the
general Gaithersburg, Maryland, area (the "RELOCATION SPACE"). Upon receipt of
such notice, Landlord shall have the option either to give Tenant written notice
that Landlord elects not to respond, or to give Tenant notice within 120 days of
receipt of Tenant's notice describing: (i) the available space(s), if any,
Landlord or any affiliate of Landlord (in either such event, the "RELOCATION
LANDLORD") may have or could construct which could be used for such Relocation
Space, (ii) the time period within which such space(s) could be available for
lease by Tenant, and (iii) the economic and other materials business terms of
any proposed lease thereof to Tenant (the "RELOCATION NOTICE"). The decision
whether to give a Relocation Notice and the terms thereof shall be determined by
Landlord in Landlord's sole and absolute discretion. Tenant shall have 60 days
following receipt of any Relocation Notice given by Landlord to deliver to
Landlord written notification of Tenant's acceptance of such Relocation Space
and agreement to lease such Relocation Space upon the business terms set forth
in the Relocation Notice.

         (b)      NEW LEASE. If the Relocation Landlord and Tenant thereafter
execute a lease (the "RELOCATION SPACE LEASE") for the Relocation Space, for a
term of not less than 10 years and otherwise on business and legal terms and
conditions acceptable to the Relocation

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Landlord and Tenant, respectively, in their sole and absolute discretion, as
such terms shall be set out in a new lease between the Relocation Landlord and
Tenant (the "RELOCATION SPACE LEASE"), then Tenant shall have the right to
terminate this Lease upon acceptance of such Relocation Space, and the
commencement of the payment of monthly rent (or rental abatement period, if any)
under such Relocation Space Lease. Upon any such termination of the Lease Tenant
shall be released from further liability thereunder, other than with respect to
any provision of the Lease which survives termination thereof.

         (c)      LIMITATIONS. Notwithstanding the above, Tenant's Relocation
Right shall not be in effect and may not be exercised by Tenant:

                  (i)      during any period of time that a Tenant Event of
         Default under any provision of the Lease exists; or

                  (ii)     if there have been 3 or more Tenant Events of Default
         under any provision of the Lease, whether or not such Events of Default
         are cured, during the 12 month period prior to the date on which Tenant
         seeks to exercise Tenant's Relocation Right.

         (d)      TERMINATION OF RELOCATION RIGHT. If for any reason whatsoever,
(i) Landlord elects not to give a Relocation Notice, (ii) Tenant fails to timely
deliver notice accepting the terms of a Relocation Notice, or (iii) Replacement
Landlord and Tenant are unable, within 6 months of Landlord's delivery of any
Relocation Notice, to agree on the business and legal terms and conditions for
any Relocation Space Lease, Tenant's rights hereunder shall terminate and be of
no further force or effect and Tenant shall have no right to lease the
Relocation Space, if any, proposed by Relocation Landlord.

         (e)      RIGHTS PERSONAL. Tenant's Relocation Right is personal to
Tenant and is not assignable without Landlord's consent, which may be granted or
withheld in Landlord's sole discretion (except that these rights shall inure to
the benefit of any assignee as a result of an assignment described in Sections
25.2 and/or 25.3 of the Lease to which Landlord consents as described therein).

         (f)      NO EXTENSIONS. The period of time within which the Relocation
Right may be exercised shall not be extended or enlarged by reason of the
Tenant's inability to exercise the Relocation Right.

         2.       MISCELLANEOUS.

         (a)      This First Amendment is the entire agreement between the
parties with respect to the subject matter hereof and supersedes all prior and
contemporaneous oral and written agreements and discussions. This First
Amendment may be amended only by an agreement in writing, signed by the parties
hereto.

         (b)      This First Amendment is binding upon and shall inure to the
benefit of the parties hereto, their respective agents, employees,
representatives, officers, directors, divisions, subsidiaries, affiliates,
assigns, heirs, successors in interest and shareholders.

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         (c)      This First Amendment may be executed in any number of
counterparts, each of which shall be deemed an original, but all of which when
taken together shall constitute one and the same instrument. The signature page
of any counterpart may be detached therefrom without impairing the legal effect
of the signature(s) thereon provided such signature page is attached to any
other counterpart identical thereto except having additional signature pages
executed by other parties to this First Amendment attached thereto.

         (d)      Landlord and Tenant each represent and warrant that it has not
dealt with any broker, agent or other person (collectively "BROKER") in
connection with this transaction, and that no Broker, brought about this
transaction. Landlord and Tenant each hereby agree to indemnify and hold the
other harmless from and against any claims by any Broker claiming a commission
or other form of compensation by virtue of having dealt with Tenant or Landlord,
as applicable, with regard to this leasing transaction.

         (e)      Except as amended and/or modified by this First Amendment, the
Lease is hereby ratified and confirmed and all other terms of the Lease shall
remain in full force and effect, unaltered and unchanged by this First
Amendment. In the event of any conflict between the provisions of this First
Amendment and the provisions of the Lease, the provisions of this First
Amendment shall prevail. Whether or not specifically amended by this First
Amendment, all of the terms and provisions of the Lease are hereby amended to
the extent necessary to give effect to the purpose and intent of this First
Amendment.

         IN WITNESS WHEREOF, the parties hereto have executed this First
Amendment as of the day and year First above written.

                                     TENANT:

                                     GENE LOGIC INC., a Delaware corporation

                                     By:  /s/ Philip L. Rohrer, Jr.
                                        ---------------------------------
                                     Its: Chief Financial Officer
                                        ---------------------------------

                                     LANDLORD:

                                     ARE - 708 QUINCE ORCHARD, LLC, a Delaware
                                     limited liability company

                                        ARE - QRS CORP., a Maryland corporation

                                        By:   /s/ Joel S. Marcus
                                           ---------------------------
                                        Its:   Chief Executive Officer
                                            --------------------------
                                        Name:   Joel S. Marcus
                                             -------------------------

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                                                                   EXHIBIT 10.68

                              EMPLOYMENT AGREEMENT

        THIS EMPLOYMENT AGREEMENT (the "Agreement") is made and entered into as
of September 7, 1996 by and between GENE LOGIC INC., a Delaware corporation (the
"Company") and ERIC M. EASTMAN, a Texas resident ("Eastman").

                                    RECITAL:

        The Company desires to secure the services of Eastman and Eastman
desires to perform such services for the Company on the terms and conditions as
set forth in this Agreement.

        NOW, THEREFORE, in consideration of these premises and the mutual
promises and conditions contained in this Agreement, the parties hereto hereby
agree as follows:

        1. Employment and Duties. Subject to the terms and conditions of this
Agreement, the Company shall employ Eastman as Vice President, Scientific
Operations and Eastman hereby accepts such employment and such position. Eastman
shall devote his full time, ability, attention, knowledge and skill to
performing all duties as Vice President, Scientific Operations, as lawfully
assigned or delegated to him by the Chief Executive Officer of the Company.

        2. Base Salary. In consideration for Eastman's services to the Company
during the term of his employment under this Agreement, Eastman shall receive an
annual base salary of $140,000 during 1996, $160,000 during 1997, and thereafter
in such amounts as may be mutually agreed by the Company and Eastman. Base
salary shall be paid in equal, bi-weekly installments from which the Company
shall withhold and deduct all applicable federal and state income, social
security, disability and other taxes as required by applicable laws.

        3. Incentive Stock.  In addition to the salary specified above, the
Company shall provide Eastman with stock incentives as follows:

               3.1    Incentive Stock Options. Upon commencement of the term of
employment engaged by this Agreement, the Company shall grant to Eastman
incentive stock options to purchase 75,000 shares of the Company's common stock
at a purchase price of $0.15 per share. While this Agreement remains in force,
such options shall become exercisable according to the following schedule:
twenty-five percent (25%) upon the date of commencement and thereafter at a rate
of 1/36th each month for 36 months beginning upon the first anniversary of such
date. Any unexercisable options held by Eastman pursuant to this Subsection 3.1
shall automatically become exercisable upon the date upon which a registration
statement for the sale of securities of the Company to the public becomes
effective, or upon any merger of the Company or sale of the Company or all or
substantially all of its assets.

               3.2    Effect of Termination by Eastman. In the event Eastman
terminates this Agreement prior to its first anniversary, all vested stock shall
become unvested and the Company shall have the right to repurchase any shares of
the Company's stock acquired by Eastman under Subsection 3.1 above, such
repurchase to occur at a purchase price equal to Eastman's original purchase
price for such shares.

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        4.     Additional Compensation and Benefits.

               4.1    Signing Bonus.  Upon the execution of this Agreement, the
Company shall pay to Eastman a cash signing bonus in the amount of $20,000.

               4.2    Annual Performance Bonus. During each calendar year while
this Agreement remains in force, commencing with 1996, Eastman shall receive, in
addition to the base salary specified in Section 2 above, a performance bonus
based upon achievement of goals mutually agreed by Eastman and the Chief
Executive Officer of the Company. The amount of such bonus for 1996 shall be
$20,000 in cash; thereafter any annual bonus shall be in such amount as may be
mutually agreed by the Company and Eastman, but not less than $20,000 for
calendar year 1997.

               4.3    Relocation Expenses and Allowances. The Company shall
reimburse Eastman on a tax grossed-up basis for all reasonable moving expenses,
temporary accommodation and house-hunting expenses and other costs related to
his relocation to the vicinity of the Company's headquarters, including seller's
closing costs on the sale of Eastman's existing house and purchaser's closing
costs on the purchase of a new home, including up to three (3) points on the new
mortgage for such purchase.

               4.4    Medical Benefits, Vacation and Sick Leave. Eastman shall
be entitled to participate in such medical, health and life insurance plans as
the Company may from time to time implement, and to receive twenty (20) days of
paid vacation per year and sick leave on the same basis as the Company's other
senior executives.

               4.5    Pension Plan. Eastman shall be entitled to participate as
a beneficiary under such pension plan(s) as the Company may from time to time
adopt, on the same basis as the Company's other senior executives.

        5.     Confidentiality and Proprietary Inventions Agreement. Upon the
commencement of the term of this Agreement. Eastman shall enter into the
Company's standard form of agreement relating to the treatment of the Company's
confidential information and ownership of proprietary inventions.

        6.     Term of Employment. Subject to the provisions of Section 7, the
term of the employment engaged by this Agreement shall be a period of four (4)
years commencing on September 23, 1996 and ending on September 22, 2000,
whereupon the term shall automatically renew for successive one (1) year periods
unless one of the parties to the Agreement shall have given notice of its
intention to terminate the Agreement not later than ninety (90) days prior to
the end of such initial term or any such renewal term.

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        7.     Terminiation of Employment.

               7.1    For Cause. The Company may terminate this Agreement,
effective immediately upon written notice to Eastman, if at any time, in the
reasonable opinion of the Company's Board of Directors, (a) Eastman commits any
material act of dishonesty, fraud or embezzlement with respect to the Company or
any subsidiary or affiliate thereof, (b) is convicted of a crime of moral
turpitude, or (c) breaches any material obligation under this Agreement. The
Company's total liability to Eastman in the event of termination of Eastman's
employment under this Subsection 7.1 shall be limited to the payment of
Eastman's salary and benefits through the effective date of termination.

               7.2    Without Cause. The Company may terminate this Agreement
without cause upon thirty (30) days' written notice to Eastman. Upon any
termination of this Agreement without cause by the Company, the Company shall
pay to Eastman as severance pay in one lump sum an amount equal to three (3)
months of his then current salary in addition to such other compensation to
which Eastman may be entitled prior to the date of termination.

               7.3    By Eastman. Eastman reserves the right to terminate his
employment hereunder for any reason upon thirty (30) days' written notice to the
Company. The Company's total liability to Eastman in the event of termination of
Eastman's employment under this Subsection 7.3 shall be limited to the payment
of Eastman's salary and benefits through the effective date of termination and
the provisions of Subsection 7.2 shall not apply.

        8.     Miscellaneous.

               8.1    Modification. Any modification of this Agreement shall be
effective only if reduced to writing and signed by the parties to be bound
thereby.

               8.2    Entire Agreement. This Agreement constitutes the entire
agreement between the Company and Eastman pertaining to the subject matter
hereof and supersedes all prior or contemporaneous written or verbal agreements
and understandings between the parties in connection with the subject matter
hereof.

               8.3    Severability. If any provision of this Agreement is held
by a court of competent jurisdiction to be invalid, void or unenforceable, the
remaining provisions shall, nevertheless, continue in full force and effect
without being impaired or invalidated in any way.

               8.4    Waiver. The parties hereto shall not be deemed to have
waived any of their respective rights under this Agreement unless the waiver is
in writing and signed by the waiving party. No delay in exercising any right
shall be a waiver of such right nor shall a waiver of any right on one occasion
operate as a waiver of such right on a future occasion.

               8.5    Costs of Enforcement. If any action or proceeding shall
be  commenced to enforce this Agreement or any right arising in connection with
this Agreement, each party shall initially bear its own costs and legal fees
associated with such action or proceeding. The prevailing party in any such
action or proceeding shall be entitled to recover from the other party the
reasonable attorneys' fees, costs and expenses incurred by such prevailing
party in connection with such action or proceeding.

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               8.6    Notices. All notices provided for herein shall be in
writing and delivered personally or sent by United States mail, registered or
certified, postage paid or by Federal Express, addressed as follows:

           To the Company:   Gene Logic Inc.
                             10150 Old Columbia Road
                             Columbia, MD 20146

           To Eastman:       Eric M. Eastman
                             47 E. Greywing Circle
                             The Woodlands, TX 77382

or to such other addresses as either of such parties may from time to time
designate in writing. Any notice given under this Agreement shall be deemed to
have been given on the date of actual receipt, or, if not received during normal
business hours, on the next business day.

        IN WITNESS WHEREOF, the parties have executed this Agreement by their
duly authorized officers or agents as of the date first written above.

"Company"                                        "Employee"

GENE LOGIC INC.                               By: /S/ ERIC M. EASTMAN
a Delaware corporation                           -----------------------------
                                                 Eric M. Eastman

By: /s/ MICHAEL J. BRENNAN
   -----------------------------------------

Name: Dr. Michael J. Brennan
      --------------------------------------

Title: President and Chief Executive Officer
       -------------------------------------

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