Document:

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                           LAKEHEAD PIPE LINE COMPANY,

                               LIMITED PARTNERSHIP

                                     Issuer

                                       and

                            THE CHASE MANHATTAN BANK

                                     Trustee

                          THIRD SUPPLEMENTAL INDENTURE

                          Dated as of November 21, 2000

                           7.9% Senior Notes Due 2012

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                                TABLE OF CONTENTS

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<S>                   <C>                                                                             <C>
ARTICLE I             Relation to Indenture; Definitions................................................1

         Section 1.01          Relation to Indenture....................................................1

         Section 1.02          Definitions and References...............................................1

ARTICLE II            The Series of Securities..........................................................2

         Section 2.01          The Title of the Securities..............................................2

         Section 2.02          Limitation on Aggregate Principal Amount.................................3

         Section 2.03          Stated Maturity..........................................................3

         Section 2.04          Interest and Interest Rates..............................................3

         Section 2.05          Place of Payment.........................................................3

         Section 2.06          Place of Registration or Exchange; Notices and Demands With
                               Respect to the Notes.....................................................3

         Section 2.07          Percentage of Principal Amount...........................................4

         Section 2.08          Global Securities........................................................4

         Section 2.09          Form of Notes............................................................4

         Section 2.10          Securities Registrar.....................................................4

         Section 2.11          Defeasance and Discharge; Covenant Defeasance............................4

         Section 2.12          Optional Redemption......................................................4

         Section 2.13          Sinking Fund Obligations.................................................5

ARTICLE III           Miscellaneous.....................................................................5

         Section 3.01          Certain Trustee Matters..................................................5

         Section 3.02          Continued Effect.........................................................5

         Section 3.03          Governing Law............................................................5

         Section 3.04          Counterparts.............................................................5
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     THIRD SUPPLEMENTAL INDENTURE, dated as of November 21, 2000 (herein called
the "Third Supplemental Indenture"), between LAKEHEAD PIPE LINE COMPANY, LIMITED
PARTNERSHIP, a Delaware limited partnership (herein called the "Company"),
having its principal office at Lake Superior Place, 21 West Superior Street,
Duluth, Minnesota 55802 and THE CHASE MANHATTAN BANK, a banking corporation duly
organized and existing under the laws of the State of New York, as trustee under
the Indenture referred to below (herein called the "Trustee").

                             RECITALS OF THE COMPANY

     WHEREAS, the Company has heretofore executed and delivered to the Trustee
the Indenture, dated as of September 15, 1998 (herein called the "Indenture"),
providing for the issuance from time to time of one or more series of the
Company's unsecured senior debentures, notes or other evidences of indebtedness
(herein called the "Securities"); and

     WHEREAS, Section 301 of the Indenture provides that various matters with
respect to any series of Securities issued under the Indenture may be
established in an indenture supplemental to the Indenture; and

     WHEREAS, Section 901(4) of the Indenture provides that the Company and the
Trustee may enter into indentures supplemental to the Indenture for the purpose
of establishing the form or terms of the Securities of any series as permitted
in Sections 201 and 301 of the Indenture; and

     WHEREAS, the Company desires to create a series of the Securities in an
aggregate principal amount of up to $100,000,000, which series shall be
designated the 7.9% Senior Notes Due 2012 (the "Notes"), and all action on the
part of the Company necessary to authorize the issuance of the Notes under the
Indenture and this Third Supplemental Indenture has been duly taken; and

     WHEREAS, all acts and things necessary to make the Notes, when executed by
the Company and authenticated and delivered by the Trustee as provided in the
Indenture and this Third Supplemental Indenture, the valid and binding
obligations of the Company and to make this Third Supplemental Indenture a valid
and binding agreement in accordance with the Indenture have been done and
performed;

     NOW, THEREFORE, THIS THIRD SUPPLEMENTAL INDENTURE WITNESSETH:

     That in consideration of the premises and the issuance of the Notes, the
Company covenants and agrees with the Trustee, for the equal and proportionate
benefit of all holders of the Notes, as follows:

                                   ARTICLE I

                       RELATION TO INDENTURE; DEFINITIONS

SECTION 1.01 Relation to Indenture.

     This Third Supplemental Indenture constitutes an integral part of the
Indenture.

SECTION 1.02 Definitions and References.

     For all purposes of this Third Supplemental Indenture:

<PAGE>   4

     (1) Capitalized terms used herein shall have the meanings specified herein
or in the Indenture, as the case may be;

     (2) "Comparable Treasury Issue" means the United States Treasury security
or securities selected by an Independent Investment Banker as having an actual
or interpolated maturity comparable to the remaining term of the Notes to be
redeemed that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities
of a comparable maturity to the remaining term of the Notes;

     (3) "Comparable Treasury Price" means, for any Redemption Date relating to
the Notes, (A) the average of the Reference Treasury Dealer Quotations for such
Redemption Date, after excluding the highest and lowest such Reference Treasury
Dealer Quotations, or (B) if the Trustee obtains fewer than four such Reference
Treasury Dealer Quotations, the average of all such quotations;

     (4) "Independent Investment Banker" means one of the Reference Treasury
Dealers appointed by the Trustee after consultation with the Company;

     (5) "Reference Treasury Dealer" means each of Merrill Lynch, Pierce, Fenner
& Smith Incorporated, plus four other dealers selected by the Trustee, or their
affiliates that are primary U.S. government securities dealers, and their
respective successors;

     (6) "Reference Treasury Dealer Quotations" means, for each Reference
Treasury Dealer and any Redemption Date relating to the Notes, the average, as
determined by the Trustee, of the bid and asked prices for the Comparable
Treasury Issue (expressed in each case as a percentage of its principal amount)
quoted in writing to the Trustee by such Reference Treasury Dealer at 3:30 p.m.,
New York time, on the third Business Day preceding such Redemption Date;

     (7) "Treasury Rate" means, for any Redemption Date relating to the Notes,
the rate per annum equal to the semiannual equivalent yield to maturity or
interpolated (on a day count basis) of the Comparable Treasury Issue, assuming a
price for the Comparable Treasury Issue (expressed as a percentage of its
principal amount) equal to the Comparable Treasury Price for that Redemption
Date;

     (8) All references herein to Articles and Sections, unless otherwise
specified, refer to the corresponding Articles and Section of this Third
Supplemental Indenture; and

     (9) The term "herein", "hereof", "hereunder" and other words of similar
import refer to this Third Supplemental Indenture.

                                   ARTICLE II

                            THE SERIES OF SECURITIES

Section 2.01 The Title of the Securities.

     There shall be a series of Securities designated the 7.9% Senior Notes due
2012 (the "Notes"). The Notes shall be executed, authenticated and delivered in
accordance with the provisions of, and shall in all respects be subject to, the
terms, conditions and covenants of

                                      -2-

<PAGE>   5

the Indenture and this Third Supplemental Indenture (including the form of Note
set forth as Exhibit A hereto).

SECTION 2.02 Limitation on Aggregate Principal Amount.

     The aggregate principal amount of the Notes shall be limited to
$100,000,000, provided, however, that the Notes may be reopened, without the
consent of Holders of the Notes, for increases in the authorized aggregate
principal amount of the Notes and issuances of additional Notes.

SECTION 2.03 Stated Maturity.

     The Stated Maturity of the Notes shall be November 21, 2012.

SECTION 2.04 Interest and Interest Rates.

     The rate of interest on each Note shall be 7.9% per annum, accruing from
November 21, 2000 and interest shall be payable, semi-annually in arrears, on
May 21 and November 21, of each year (each such date, an "Interest Payment
Date"), commencing May 21, 2001 to the Persons in whose names the Notes are
registered at the close of business on the immediately preceding May 6 and
November 6 respectively, whether or not such day is a Business Day (each such
date, a "Regular Record Date"). The amount of interest payable for any period
shall be computed on the basis of twelve 30-day months and a 360-day year. The
amount of interest payable for any partial period shall be computed on the basis
of a 360-day year of twelve 30-day months and the days elapsed in any partial
month. In the event that any date on which interest is payable on a Note is not
a Business Day, then a payment of the interest payable on such date will be made
on the next succeeding day which is a Business Day (and without any interest or
other payment in respect of any such delay) with the same force and effect as if
made on the date the payment was originally payable. The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will be
paid to the Person in whose name such Note (or one or more Predecessor
Securities) is registered at the close of business on the Regular Record Date
for such interest. Any such interest not so punctually paid or duly provided for
shall forthwith cease to be payable to the Holder on such Regular Record Date
and shall either (i) be paid to the Person in whose name such Note (or one or
more Predecessor Securities) is registered at the close of business on the
Special Record Date for the payment of such Defaulted Interest to be fixed by
the Trustee, notice of which shall be given to Holders of the Notes not less
than 10 days prior to such Special Record Date, or (ii) be paid at such time in
any other lawful manner not inconsistent with the requirements of any securities
exchange or automated quotation system on which the Notes may be listed or
traded, and upon such notice as may be required by such exchange or automated
quotation system, all as more fully provided in the Indenture.

SECTION 2.05 Place of Payment.

     The Place of Payment where the Notes may be presented or surrendered for
payment shall initially be the Corporate Trust Office of the Trustee in the City
and State of New York.

SECTION 2.06 Place of Registration or Exchange; Notices and Demands With Respect
to the Notes.

     The place where the Holders of the Notes may present the Notes for
registration of transfer or exchange and may make notices and demands to or upon
the Company in respect of the Notes shall initially be the Corporate Trust
Office of the Trustee in the City and State of New York.

                                      -3-

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SECTION 2.07 Percentage of Principal Amount.

     The Notes shall be issued at 99.824% of their principal amount.

SECTION 2.08 Global Securities.

     The Notes shall initially be issuable in the form of one or more Global
Securities. Such Global Securities shall be deposited with, or on behalf of, The
Depository Trust Company, New York, New York, which shall act as Depositary with
respect to the Notes. Such Global Securities shall bear the legends set forth in
the form of Note attached as Exhibit A hereto.

SECTION 2.09 Form of Notes.

     The Notes shall be substantially in the form attached as Exhibit A hereto.
The Notes shall be registered in such names, shall be in such amounts and shall
have such other specific terms contemplated in the form of Note attached hereto
as Exhibit A, as shall be communicated by the Company to the Trustee in
accordance with the administrative procedures, as in effect from time to time,
established to provide for the issuance of the Notes.

SECTION 2.10 Securities Registrar.

     The Trustee shall serve as the initial Securities Registrar.

SECTION 2.11 Defeasance and Discharge; Covenant Defeasance.

     Article XIII of the Indenture, including without limitation, Sections 1302
and 1303 thereof, shall apply to the Notes.

SECTION 2.12 Optional Redemption.

     The Notes are subject to redemption upon not less than 30 nor more than 60
days' notice by mail, at the election of the Company at any time, as a whole or
in part, in principal amounts of $1,000 or any integral multiple thereof at any
time at a Redemption Price equal to the greater of (a) 100% of the principal
amount thereof and (b) the sum of the present values of the remaining scheduled
payments of principal and interest on the Notes, exclusive of interest accrued
to such Redemption Date, discounted to such Redemption Date on a semiannual
basis, assuming a 360-day year consisting of twelve 30-day months, at the
Treasury Rate plus 37.5 basis points, plus, in each case, accrued interest to
such Redemption Date; provided, that installments of interest on Notes that are
due and payable on any date on or prior to a Redemption Date shall be payable to
the registered Holders of such Notes (or one or more Predecessor Securities),
registered as such as of the close of business on the relevant Record Dates. The
Redemption Price shall be calculated and certified to the Trustee by the
Independent Investment Banker so appointed by it; provided that if the
institution so appointed has notified the Trustee in writing at least fifteen
days prior to the Redemption Date that it is unwilling or unable to make such
calculation, such calculation shall be made by another Independent Investment
Banker appointed by the Trustee at the cost and expense of the Company. The
Redemption Price included in the notice to the Holders shall state that the
Redemption Price as set forth therein has been calculated in accordance with
this Section 2.12.

                                      -4-

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SECTION 2.13 Sinking Fund Obligations.

     The Company has no obligation to redeem or purchase any Notes pursuant to
any sinking fund or analogous requirement or upon the happening of a specified
event or at the option of a Holder thereof.

                                  ARTICLE III

                                  MISCELLANEOUS

SECTION 3.01 Certain Trustee Matters.

     The recitals contained herein shall be taken as the statements of the
Company, and the Trustee assumes no responsibility for their correctness.

     The Trustee makes no representations as to the validity or sufficiency of
this Third Supplemental Indenture or the proper authorization or the due
execution hereof by the Company.

SECTION 3.02 Continued Effect.

     Except as expressly supplemented and amended hereby, the Indenture shall
continue in full force and effect in accordance with the provisions thereof, and
the Indenture, as supplemented and amended hereby, is in all respects hereby
ratified and confirmed. This Third Supplemental Indenture and all its provisions
shall be deemed a part of the Indenture in the manner and to the extent herein
and therein provided.

SECTION 3.03 Governing Law.

     This Third Supplemental Indenture and the Notes shall be governed by and
construed in accordance with the laws of the State of New York.

SECTION 3.04 Counterparts.

     This instrument may be executed in any number of counterparts, each of
which shall be deemed to be an original, but all such counterparts shall
together constitute but one and the same instrument.

     IN WITNESS WHEREOF, the parties hereto have caused this Third Supplemental
Indenture to be duly executed, all as of the day and year first above written.

                                    LAKEHEAD PIPE LINE COMPANY,
                                    LIMITED PARTNERSHIP

                                    By:  Lakehead Pipe Line Company, Inc.
                                             Its General Partner

                                    By:
                                           ------------------------------------
                                    Name:
                                    Title:

                                      -5-

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                                    Attest:
                                           ------------------------------------
                                    Name:
                                    Title:

                                    THE CHASE MANHATTAN BANK,
                                        as Trustee

                                    By:
                                           ------------------------------------
                                    Name:
                                    Title:  Authorized Officer

                                    Attest:
                                           ------------------------------------
                                    Name:
                                    Title:

                                      -6-

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                                                                       EXHIBIT A

                             [FORM OF FACE OF NOTE]

     [If the Note is a Global Security, insert - THIS NOTE IS A GLOBAL SECURITY
WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN
THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS NOTE MAY NOT BE TRANSFERRED
TO, OR REGISTERED OR EXCHANGED FOR NOTES REGISTERED IN THE NAME OF, ANY PERSON
OTHER THAN THE DEPOSITARY OR A NOMINEE THEREOF AND NO SUCH TRANSFER MAY BE
REGISTERED, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE.
EVERY NOTE AUTHENTICATED AND DELIVERED UPON REGISTRATION OF TRANSFER OF, OR IN
EXCHANGE FOR OR IN LIEU OF, THIS NOTE SHALL BE A GLOBAL SECURITY SUBJECT TO THE
FOREGOING, EXCEPT IN SUCH LIMITED CIRCUMSTANCES.

     UNLESS THIS NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE
DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION, TO THE COMPANY OR ITS AGENT
FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY NOTE ISSUED IS
REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME AS IS REQUESTED BY AN
AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT IS
MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER
USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL IN AS MUCH AS
THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.]

                 LAKEHEAD PIPE LINE COMPANY, LIMITED PARTNERSHIP

                           7.9% SENIOR NOTES DUE 2012

NO.                                                            U.S.$___________
CUSIP No.

     LAKEHEAD PIPE LINE COMPANY, LIMITED PARTNERSHIP, a Delaware limited
partnership (herein called the "Company", which term includes any successor
Person under the Indenture hereinafter referred to), for value received, hereby
promises to pay to ____________, or registered assigns, the principal sum of
$_____________ United States Dollars on November 21, 2012, and to pay interest
thereon from November 21, 2000, or from the most recent Interest Payment Date to
which interest has been paid or duly provided for, semi-annually on May 21 and
November 21 in each year, commencing May 21, 2001, at the rate of 7.9% per
annum, until the principal hereof is paid or made available for payment, and at
a rate of 7.9% per annum on any overdue principal or Redemption Price, as
applicable, and on any overdue installment of interest. The amount of interest
payable for any period shall be computed on the basis of twelve 30-day months
and a 360-day year. The amount of interest payable for any partial period shall
be computed on the basis of a 360-day year of twelve 30-day months and the days
elapsed in any partial month. In the event that any date on which interest is
payable on this Note is not a Business Day, then a payment of the interest
payable on such date will be made on the next succeeding day which is a Business
Day (and without any interest or other payment in respect of any such delay)
with the same force and effect as if made on the date the payment was originally
payable. A "Business Day" shall mean, when used with respect to any Place of

                                      A-1

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Payment, each Monday, Tuesday, Wednesday, Thursday and Friday which is not a day
on which banking institutions in that Place of Payment are authorized or
obligated by law, executive order or regulation to close. The interest so
payable, and punctually paid or duly provided for, on any Interest Payment Date
will, as provided in such Indenture, be paid to the Person in whose name this
Note (or one or more Predecessor Securities) is registered at the close of
business on the Regular Record Date for such interest, which shall be the May 6
or November 6 (whether or not a Business Day), as the case may be, next
preceding such Interest Payment Date. Any such interest not so punctually paid
or duly provided for shall forthwith cease to be payable to the Holder on such
Regular Record Date and shall either (i) be paid to the Person in whose name
this Note (or one or more Predecessor Securities) is registered at the close of
business on a Special Record Date for the payment of such Defaulted Interest to
be fixed by the Trustee, notice of which shall be given to Holders of Notes not
less than 10 days prior to such Special Record Date, or (ii) be paid at such
time in any other lawful manner not inconsistent with the requirements of any
securities exchange or automated quotation system on which the Notes may be
listed or traded, and upon such notice as may be required by such exchange or
automated quotation system, all as more fully provided in such Indenture.

     [If the Note is a Global Security, insert - Payment of the principal or
Redemption Price (as applicable) of and interest on this Note will be made by
transfer of immediately available funds to a bank account in the City and State
of New York designated by the Holder in such coin or currency of the United
States of America as at the time of payment is legal tender for payment of
public and private debts.]

     [If the Note is a Definitive Security, insert - Payment of the principal or
Redemption Price (as applicable) and interest on this Note will be made at the
office or agency of the Company maintained for that purpose in the City and
State of New York or at such other offices or agencies as the Company may
designate, in such coin or currency of the United States of America as at the
time of payment is legal tender for payment of public and private debts, or
subject to any laws or regulations applicable thereto, at the option of the
Company, by United States Dollar check drawn on, or transfer to a United States
Dollar account maintained by the payee with, a bank in the City and State of New
York (so long as the applicable Paying Agent has received proper transfer
instructions in writing by the Record Date prior to the applicable payment
date); provided, however, that payment at maturity will only be made against
presentation and surrender of this Note; and provided, further, that any Holder
of this Note who is the Holder of at least $1.0 million aggregate principal
amount of Notes may request to have any payment of interest on this Note be made
by transfer to a United States Dollar account maintained by the payee with a
bank in the United States (so long as the applicable Paying Agent has received
proper transfer instructions in writing by the Record Date prior to the
applicable Interest Payment Date).]

     Reference is hereby made to the further provisions of this Note set forth
on the reverse hereof, which further provisions shall for all purposes have the
same effect as if set forth at this place.

     Unless the certificate of authentication hereon has been executed by the
Trustee referred to on the reverse hereof by manual signature, this Note shall
not be entitled to any benefit under the Indenture or be valid or obligatory for
any purpose.

                                      A-2

<PAGE>   11

     IN WITNESS WHEREOF, the Company has caused this instrument to be duly
executed.

Dated:
       ----------------------
                                     LAKEHEAD PIPE LINE COMPANY,
                                        LIMITED PARTNERSHIP

                                     By:   Lakehead Pipe Line Company, Inc.,
                                                Its General Partner

                                     By:
                                           -----------------------------------
                                     Name:
                                     Title:

                     TRUSTEE'S CERTIFICATE AND AUTHORIZATION

         This is one of the Notes designated therein referred to in the
                          within-mentioned Indenture.

                                     THE CHASE MANHATTAN BANK,
                                        As Trustee

                                     By:
                                           -----------------------------------
                                                   Authorized Officer

                                      A-3

<PAGE>   12

                            [FORM OF REVERSE OF NOTE]

     This Note is one of a duly authorized issue of Securities of the Company
(the "Notes"), issued and to be issued in one or more series under an Indenture
dated as of September 15, 1998 (the "Indenture"), between the Company and The
Chase Manhattan Bank, as Trustee (the "Trustee", which term includes any
successor trustee under the Indenture), to which Indenture and all indentures
supplemental thereto reference is hereby made for a statement of the respective
rights, limitations of rights, obligations, duties and immunities thereunder of
the Company, the Trustee and the Holders of the Notes and of the terms upon
which the Notes are, and are to be, authenticated and delivered. As provided in
the Indenture, the Securities may be issued in one or more series, which
different series may be issued in various aggregate principal amounts, may
mature at different times, may bear interest, if any, a different rates, may be
subject to different redemption provisions, if any, may be subject to different
sinking, purchase or analogous funds, if any, may be subject to different
covenants and Events of Default and may otherwise vary as in the Indenture
provided or permitted. This Note is one of a series of Securities designated on
the face hereof limited in aggregate principal amount to U.S. $100,000,000;
provided, however, that the Notes may be reopened, without the consent of
Holders of the Notes, for increases in the authorized aggregate principal amount
of the Notes and issuances of additional Notes.

     The Notes are subject to redemption upon not less than 30 nor more than 60
days' notice by mail, at the election of the Company at any time, as a whole or
in part, in principal amounts of $1,000 or any integral multiple thereof at any
time at a Redemption Price equal to the greater of (a) 100% of the principal
amount thereof and (b) the sum of the present values of the remaining scheduled
payments of principal and interest on the Notes, exclusive of interest accrued
to such Redemption Date, discounted to such Redemption Date on a semiannual
basis, assuming a 360-day year consisting of twelve 30-day months, at the
Treasury Rate plus 37.5 basis points, plus, in each case, accrued interest to
such Redemption Date; provided, that installments of interest on Notes that are
due and payable on any date on or prior to a Redemption Date shall be payable to
the registered Holders of such Notes (or one or more Predecessor Securities),
registered as such as of the close of business on the relevant Record Dates
referred to on the face hereof, all as provided in the Indenture.

     Capitalized terms used herein shall have the meanings specified herein or
in the Indenture, as the case may be;

     "Comparable Treasury Issue" means the United States Treasury security or
securities selected by an Independent Investment Banker as having an actual or
interpolated maturity comparable to the remaining term of the Notes to be
redeemed that would be utilized, at the time of selection and in accordance with
customary financial practice, in pricing new issues of corporate debt securities
of a comparable maturity to the remaining term of the Notes;

     "Comparable Treasury Price" means, for any Redemption Date relating to the
Notes, (1) the average of the Reference Treasury Dealer Quotations for such
Redemption Date, after excluding the highest and lowest such Reference Treasury
Dealer Quotations, or (2) if the Trustee obtains fewer than four such Reference
Treasury Dealer Quotations, the average of all such quotations;

     "Independent Investment Banker" means one of the Reference Treasury Dealers
appointed by the Trustee after consultation with the Company;

                                      A-4

<PAGE>   13

     "Reference Treasury Dealer" means each of Merrill Lynch, Pierce, Fenner &
Smith Incorporated, plus four other dealers selected by the Trustee, or their
affiliates that are primary U.S. government securities dealers, and their
respective successors;

     "Reference Treasury Dealer Quotations" means, for each Reference Treasury
Dealer and any Redemption Date relating to the Notes, the average, as determined
by the Trustee, of the bid and asked prices for the Comparable Treasury Issue
(expressed in each case as a percentage of its principal amount) quoted in
writing to the Trustee by such Reference Treasury Dealer at 3:30 p.m., New York
time, on the third Business Day preceding such Redemption Date; and

     "Treasury Rate" means, for any Redemption Date relating to the Notes, the
rate per annum equal to the semiannual equivalent yield to maturity or
interpolated (on a day count basis) of the Comparable Treasury Issue, assuming a
price for the Comparable Treasury Issue (expressed as a percentage of its
principal amount) equal to the Comparable Treasury Price for that Redemption
Date.

     All references herein to Articles and Sections, unless otherwise specified,
refer to the corresponding Articles and Section of this Third Supplemental
Indenture.

     The term "herein", "hereof", "hereunder" and other words of similar import
refer to this Third Supplemental Indenture.

     In the event of redemption of this Note in part only, a new Note or Notes
of like tenor for the unredeemed portion hereof will be issued in the name of
the Holder hereof upon the cancellation hereof.

     If an Event of Default with respect to the Notes shall occur and be
continuing, the principal of the Notes may be declared due and payable in the
manner and with the effect provided in the Indenture.

     The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the
Company and the rights of the Holders of the Notes to be affected under the
Indenture at any time by the Company and the Trustee with the consent of not
less than the Holders of a majority in aggregate principal amount of the
Outstanding Securities of all series to be affected (voting as one class). The
Indenture also contains provisions permitting the Holders of a majority in
aggregate principal amount of the outstanding securities of all affected series
(voting as one class), on behalf of the Holders of all Securities of such
series, to waive compliance by the Company with certain provisions of the
Indenture. The Indenture permits, with certain exceptions as therein provided,
the Holders of a majority in principal amount of Notes then Outstanding to waive
past defaults under the Indenture with respect to the Notes and their
consequences. Any such consent or waiver by the Holder of this Note shall be
conclusive and binding upon such Holder and upon all future Holders of this Note
and of any Note issued upon the registration of transfer hereof or in exchange
herefor or in lieu hereof, whether or not notation of such consent or waiver is
made upon this Note.

     As provided in and subject to the provisions of the Indenture, the Holder
of this Note shall not have the right to institute any proceeding with respect
to the Indenture or for the appointment of a receiver or trustee or for any
other remedy thereunder, unless such Holder shall have previously given the
Trustee written notice of a continuing Event of Default with respect to the
Notes, the Holders of not less than 25% in principal amount of the Notes at the
time Outstanding shall have made written request to the Trustee to institute
proceedings in respect of such Event of Default as Trustee and offered the
Trustee reasonable indemnity and the Trustee

                                      A-5

<PAGE>   14

shall not have received from the Holders of a majority in principal amount of
the Notes at the time Outstanding a direction inconsistent with such request,
and shall have failed to institute any such proceeding, for 60 days after
receipt of such notice, request and offer of indemnity. The foregoing shall not
apply to any suit instituted by the Holder of this Note for the enforcement of
any payment of principal, premium, if any, or interest hereon on or after the
respective due dates expressed herein.

     No reference herein to the Indenture and no provision of this Note or of
the Indenture shall alter or impair the obligation of the Company, which is
absolute and unconditional, to pay the principal of, premium, if any, and
interest on this Note at the times, place(s) and rate, and in the coin or
currency, herein prescribed.

     [If the Note is a Global Security, insert - This Global Security or portion
hereof may not be exchanged for Definitive Securities except in the limited
circumstances provided in the Indenture.

     The holders of beneficial interests in this Global Security will not be
entitled to receive physical delivery of Definitive Securities except as
described in the Indenture and will not be considered the Holders thereof for
any purpose under the Indenture.]

     [If the Note is a Definitive Security, insert - As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of
this Note is registrable in the Security Register, upon surrender of this Note
for registration of transfer at the office or agency of the Company in the City
and State of New York or at such other offices or agencies as the Company may
designate, duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Company and the Security Registrar duly executed by,
the Holder hereof or his attorney duly authorized in writing, and thereupon one
or more new Notes and of like tenor, of authorized denominations and for the
same aggregate principal amount, will be issued to the designated transferee or
transferees.]

     The Notes are issuable only in registered form, without coupons, in
denominations of U.S. $1,000 and any integral multiple thereof. As provided in
the Indenture and subject to certain limitations therein set forth, the Notes
are transferable and exchangeable at the office of the Registrar and any
co-registrar for a like aggregate principal amount of Notes and of like tenor of
a different authorized denomination, as requested by the Holder surrendering the
same.

     No service charge shall be made for any such registration of transfer or
exchange, but the Company may require payment of a sum sufficient to cover any
transfer tax or other similar government charge payable in connection with
certain transfers and exchanges.

     Prior to due presentment of this Note for registration of transfer, the
Company, the Trustee and any agent of the Company or the Trustee may treat the
Person in whose name this Note is registered as the owner hereof for all
purposes, whether or not this Note be overdue, and neither the Company, the
Trustee nor any such agent shall be affected by notice to the contrary.

     Obligations of the Company under the Indenture and the Securities
thereunder, including this Note, are non-recourse to Lakehead Pipe Line Company,
Inc. (the "General Partner") and Lakehead Pipe Line Partners, L.P. ("Lakehead")
and their respective Affiliates (other than the Company), and payable only out
of cash flow and assets of the Company. The Trustee, and each Holder of a Note
by its acceptance hereof, will be deemed to have agreed in the Indenture that
(1) neither the General Partner nor its assets nor Lakehead nor its assets (nor
any of their respective Affiliates other than the Company, nor their respective
assets) shall be liable for any of

                                      A-6

<PAGE>   15

the obligations of the Company under the Indenture or such Securities, including
this Note, and (2) no director, officer, employee, stockholder or unitholder, as
such, of the Company, the Trustee, the General Partner, Lakehead or any
Affiliate of any of the foregoing entities shall have any personal liability in
respect of the obligations of the Company under the Indenture or such Securities
by reason of his, her or its status. Notwithstanding the foregoing, nothing in
this paragraph shall be construed to modify or supersede any obligation of
Lakehead or the General Partner to restore any negative balance in their
respective capital accounts (maintained by the Company pursuant to the Company's
Amended and Restated Agreement of Limited Partnership) upon liquidation of their
respective interests in the Company.

     The Indenture contains provisions that relieve the Company from the
obligation to comply with certain restrictive covenants in the Indenture and for
satisfaction and discharge at any time of the entire indebtedness upon
compliance by the Company with certain conditions set forth in the Indenture.

     This Note shall be governed by and construed in accordance with the laws of
the State of New York.

     All term used in this Note which are defined in the Indenture shall have
the meanings assigned to them in the Indenture.

     [If the Note is a Definitive Security, insert as a separate page -

     FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and
transfer(s) unto ____________________________ (Please Print or Typewrite Name
and Address of Assignee) the within instrument of LAKEHEAD PIPE LINE COMPANY,
LIMITED PARTNERSHIP and does hereby irrevocably constitute and appoint
_________________________ Attorney to transfer said instrument on the books of
the within-named Company, with full power of substitution in the premises.

Please Insert Social Security or
Other Identifying Number of Assignee:

Dated:                           (Signature)
      -----------------------                -----------------------------------

NOTICE: The signature to this assignment must correspond with the name as
written upon the face of the within instrument in every particular, without
alteration or enlargement or any change whatever.]

                                      A-7<PAGE>
                                                                    Exhibit 10.1
                               -------------------------------------------------
[LOGO OF FIRSTAR]              For Bank Use Only     Reviewed by
                               -------------------------------------------------
                               Due  DECEMBER 31, 2002
                                    --------------------
                               Customer                      Loan
                                         -----------------       ---------------

                          STAND-ALONE REVOLVING NOTE

$ 6,000,000.00                                      NOVEMBER 17, 2000
 -----------------------                            ----------------------------

     FOR VALUE RECEIVED, the undersigned borrower (the "Borrower"), promises to
pay to the order of FIRSTAR BANK, N.A. (the "Bank"), the principal sum of SIX
                    ------------------                                    ---
MILLION AND NO/100 Dollars ($6,000,000.00), payable 12/31/02.
------------------          -------------           --------

     The Bank will make advances to the Borrower from time to time up to the
aggregate amount of $6,000,000.00. The Borrower may, prior to the maturity date
                    -------------
or termination as described below, borrow, repay and reborrow such amount from
the Bank. Each advance shall be in the minimum amount of $5,000.

  1. Interest.

  The unpaid principal balance will bear interest at an annual rate equal to
  the prime rate announced by the Bank.

  The interest rate hereunder will be adjusted each time that the prime rate
  changes.

  2. Payment Schedule.

  Interest is payable beginning DECEMBER 31, 2000, and on the same date of each
  CONSECUTIVE month thereafter (except that if a given month does not have such
  a date, the last day of such month), plus a final interest payment with the
  final payment of principal.

  3. Paid-in-Full Period. [_] If checked here, all revolving loans under this
Note must be paid in full for a period of at least     consecutive days during
                                                   ---
each fiscal year.

  4. Closing Fee. [_] If checked here, the Borrower will pay the Bank a one-time
closing fee of $ n/a contemporaneously with execution of this Note. This fee
               -----
is in addition to all other fees, expenses and other amounts due hereunder.

  5. Late Payment Fee. Subject to applicable law, if any payment is not made on
or before its due date, the Bank may collect a delinquency charge of 0.00% of
                                                                     -----
the unpaid amount. Collection of the late payment fee shall not be deemed to be
a waiver of the Bank's right to declare a default hereunder.

  6. Calculation of Interest. Interest will be computed for the actual number of
days principal is unpaid, using a daily factor obtained by dividing the stated
interest rate by 360.

  7. Default Interest Rate. Principal amounts remaining unpaid after the
maturity thereof, whether at fixed maturity or by reason of acceleration of
maturity, shall bear interest from and after maturity until paid at a rate of 3%
per annum plus the rate otherwise payable hereunder.

  8. Maximum Rate. In no event will the interest rate hereunder exceed that
permitted by applicable law. If any interest or other charge is finally
determined by a court of competent jurisdiction to exceed the maximum amount
permitted by law, the interest or charge shall be reduced to the maximum
permitted by law, and the Bank may credit any excess amount previously collected
against the balance due or refund the amount to the Borrower.

                                  Page 1 of 4
<PAGE>

  9. Financial Information. The Borrower will (i) maintain accounting records in
accordance with generally recognized and accepted principles of accounting
consistently applied throughout the accounting periods involved; (ii) provide
the Bank with such information concerning its business affairs and financial
condition (including insurance coverage) as the Bank may reasonably request; and
(iii) without request, provide the Bank with annual financial statements
prepared by an accounting firm acceptable to the Bank within 120 days of the end
of each fiscal year.

  10. Credit Balances; Setoff. As additional security for the payment of the
obligations described in this Note or any document securing or related to the
loan evidenced by this Note (collectively the "Loan Documents"), and any other
obligations of the Borrower to the Bank of any nature whatsoever (collectively
the "Obligations"), the Borrower hereby grants to the Bank a security interest
in, a lien on and an express contractual right to set off against all depository
account balances, cash and any other property of the Borrower now or hereafter
in the possession of the Bank and the right to refuse to allow withdrawals from
any account (collectively "Setoff"). The Bank may, at any time upon the
occurrence of a default hereunder (notwithstanding any notice requirements or
grace/cure periods under this or other agreements between the Borrower and the
Bank) Setoff against the Obligations whether or not the Obligations (including
future installments) are then due or have been accelerated, all without any
advance or contemporaneous notice or demand of any kind to the Borrower, such
notice and demand being expressly waived.

  11. Advances and Paying Procedure. The Bank is authorized and directed to
credit any of the Borrower's accounts with the Bank (or to the account the
Borrower designates in writing) for all loans made hereunder, and the Bank is
authorized to debit such account or any other account of the Borrower with the
Bank for the amount of any principal or interest due or other amount due
hereunder on the due date with respect thereto.

  12. Defaults. Notwithstanding any cure periods described below, the Borrower
shall immediately notify the Bank in writing when the Borrower obtains
knowledge of the occurrence of any default specified below. Regardless of
whether the Borrower has given the required notice, the occurence of one or more
of the following shall constitute a default:

  (a) Nonpayment. The Borrower shall fail to pay (i) any interest due on this
      Note or any fees, charges, costs or expenses under the Loan Documents by 5
      days after the same becomes due; or (ii) any principal amount of this Note
      when due.

  (b) Nonperformance. The Borrower or any guarantor of the Borrower's
      Obligations to the Bank ("Guarantor") shall fail to perform or observe any
      agreement, term, provision, condition, or covenant (other than a default
      occurring under (a), (c), (d), (e), (f) or (g) of this paragraph 12)
      required to be performed or observed by the Borrower or any Guarantor
      hereunder or under any other Loan Document or other agreement with or in
      favor of the Bank.

  (c) Misrepresentation. Any financial information, statement, certificate,
      representation or warranty given to the Bank by the Borrower or any
      Guarantor (or any of their representatives) in connection with entering
      into this Note or the other Loan Documents and/or any borrowing
      thereunder, or required to be furnished under the terms thereof, shall
      prove untrue or misleading in any material respect (as determined by the
      Bank in the exercise of its judgment) as of the time when given.

  (d) Default on Other Obligations. The Borrower or any Guarantor shall be in
      default under the terms of any loan agreement, promissory note, lease,
      conditional sale contract or other agreement, document or instrument
      evidencing, governing or securing any indebtedness owing by the Borrower
      or any Guarantor to the Bank or any indebtedness in excess of $10,000
      owing by the Borrower to any third party, and the period of grace, if any,
      to cure said default shall have passed.

  (e) Judgments. Any judgment shall be obtained against the Borrower or any
      Guarantor which, together with all other outstanding unsatisfied judgments
      against the Borrower (or such Guarantor), shall exceed the sum of $10,000
      and shall remain unvacated, unbonded or unstayed for a period of 30 days
      following the date of entry thereof.

  (f) Inability to Perform; Bankruptcy/Insolvency. (i) The Borrower or any
      Guarantor shall die or cease to exist; or (ii) any Guarantor shall attempt
      to revoke any guaranty of the Obligations described herein, or any
      guaranty becomes unenforcable in whole or in part for any reason; or (iii)
      any bankruptcy, insolvency or receivership proceedings, or an assignment
      for the benefit of creditors, shall be commenced under any Federal or
      state law by or against the Borrower or any Guarantor; or (iv) the
      Borrower or any Guarantor shall become the subject of any out-of-court
      settlement with its creditors; or (v) the Borrower or any Guarantor is
      unable or admits in writing its inability to pay its debts as they mature.

  13. Termination of Loans; Additional Bank Rights. Upon the occurence of any of
the events identified in paragraph 12, the Bank may at any time (notwithstanding
any notice requirements or grace/cure periods under this or other agreements
between the Borrower and the Bank); (ii) Setoff; and/or (iii) take such other
steps to protect or preserve the Bank's interest in any collateral, including
without limitation, notifying account debtors to make payments directly to the
Bank, advancing funds to protect any collateral and insuring collateral at the
Borrower's expense; all without demand or notice of any kind, all of which are
hereby waived.

                                  Page 2 of 4

<PAGE>

  14. Acceleration of Obligations. Upon the occurrence of any of the events
identified in paragraph 12(a) through 12(e) and the passage of any applicable
cure periods, the Bank may at any time thereafter, by written notice to the
Borrower, declare the unpaid principal balance of any Obligations, together with
the interest accrued thereon and other amounts accrued hereunder and under the
other Loan Documents, to be immediately due and payable; and the unpaid balance
shall thereupon be due and payable, all without presentation, demand, protest or
further notice of any kind, all of which are hereby waived, and notwithstanding
anything to the contrary contained herein or in any of the other Loan Documents.
Upon the occurrence of any event under paragraph 12(f), the unpaid principal
balance of any Obligations, together with all interest accrued thereon and other
amounts accrued hereunder and under the other Loan Documents, shall thereupon be
immediately due and payable, all without presentation, demand, protest or notice
of any kind, all of which are hereby waived, and notwithstanding anything to the
contrary contained herein or in any of the other Loan Documents. Nothing
contained in paragraph 12 or 13 of this paragraph shall limit the Bank's right
to Setoff as provided in this Note.

  15. Collateral. This Note is secured by any and all security interests,
pledges, mortgages or liens now or hereafter in existence granted to the Bank to
secure indebtedness of the Borrower to the Bank (unless prohibited by law),
including, without limitation, as described in the following documents:
                                                                        --------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------

 16. Guaranties. This Note is guaranteed by
                                            ------------------------------------
RICHARD B MAZESS
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------
--------------------------------------------------------------------------------

  17. Additional Bank Rights. Without affecting the liability of any Borrower,
endorser, surety or guarantor, the Bank may, without notice, renew or extend the
time for payment, accept partial payments, release or impair any collateral
security for the payment of this Note, or agree not to sue any party liable on
it.

  18. Warranties. The Borrower makes the following warranties: (A) If the
Borrower is a corporation or partnership, it is a validly existing corporation
or partnership (as applicable), in good standing under the laws of its state of
organization, and has all requisite power and authority, corporate or otherwise,
and possesses all licenses necessary, to conduct its business and own its
properties. (B) The execution, delivery and performance of this Note and all
other Loan Documents (i) are within the Borrower's power; (ii) have been duly
authorized by proper corporate or partnership action (as applicable); (iii) do
not require the approval of any governmental agency; and (iv) will not violate
any law, agreement or restriction by which the Borrower is bound. (C) This Note
and the other Loan Documents are the legal, valid and binding obligations of the
Borrower, enforceable against the Borrower in accordance with their terms.

  19. Waivers; Relationship to Other Documents. All Borrowers, endorsers,
sureties and guarantors waive presentment, protest, demand, and notice of
dishonor. The warranties, covenants and other obligations of the Borrower (and
rights and remedies of the Bank) in this Note and all related documents are
intended to be cumulative and to supplement each other.

  20. Expenses and Attorneys' Fees. The Borrower will reimburse the Bank and any
participant in the Obligations ("Participant") for all attorneys' fees and all
other costs, fees and out-of-pocket disbursements (including fees and
disbursements of both inside counsel and outside counsel) incurred by the Bank
or any Participant in connection with the preparation, execution, delivery,
administration, defense and enforcement of this Note or any of the other Loan
Documents, including fees and costs related to any waivers or amendments with
respect thereto (examples of costs and fees include but are not limited to fees
and costs for filing, perfecting or confirming the priority of the Bank's lien,
title searches or insurance, appraisals, environmental audits and other reviews
related to the Borrower, any collateral or the loans, if requested by the Bank).
The Borrower will also reimburse the Bank and any Participant for all costs of
collection before and after judgement, and the costs of preservation and/or
liquidation of any collateral (including fees and disbursements of both inside
and outside counsel).

  21. Applicable Law and Jurisdiction; Interpretation; Joint Liability. This
Note and all other Loan Documents shall be governed by and interpreted in
accordance with the internal laws of the State of Wisconsin, except to the
extent superseded by Federal law. Invalidity of any provisions of this Note
shall not affect any other provision. THE BORROWER HEREBY CONSENTS TO THE
EXCLUSIVE JURISDICTION OF ANY STATE OR FEDERAL COURT SITUATED IN THE COUNTY OR
FEDERAL JURISDICTION OF THE BANK'S BRANCH WHERE THE LOAN WAS ORIGINATED, AND
WAIVES ANY OBJECTION BASED ON FORUM NON CONVENIENS, WITH REGARD TO ANY ACTIONS,
CLAIMS, DISPUTES, OR PROCEEDINGS RELATING TO THIS NOTE, THE COLLATERAL, ANY
OTHER LOAN DOCUMENT, OR ANY TRANSACTIONS ARISING THEREFROM, OR ENFORCEMENT
AND/OR INTERPRETATION OF ANY OF THE FOREGOING. Nothing herein shall affect the
Bank's rights to serve process in any manner permitted by law, or limit the
Bank's right to bring proceedings against the Borrower in the competent courts
of any other jurisdiction or jurisdictions. This Note, the other Loan Documents
and any amendments hereto (regardless of when executed) will be deemed effective
and accepted only upon the Bank's receipt of the executed originals thereof. If
there is more than one Borrower, the liability of the Borrowers shall be joint
and several, and the reference to "Borrower" shall be deemed to refer to all
Borrowers.

  22. Copies; Entire Agreement; Modification. The Borrower hereby acknowledges
the receipt of a copy of this Note and all other Loan Documents.

                                  Page 3 of 4
<PAGE>

  IMPORTANT: READ BEFORE SIGNING. THE TERMS OF THIS AGREEMENT SHOULD BE READ
CAREFULLY BECAUSE ONLY THOSE TERMS IN WRITING ARE ENFORCEABLE. NO OTHER TERMS OR
ORAL PROMISES NOT CONTAINED IN THIS WRITTEN CONTRACT MAY BE LEGALLY ENFORCED.
THE TERMS OF THIS AGREEMENT MAY ONLY BE CHANGED BY ANOTHER WRITTEN AGREEMENT.
THIS NOTICE SHALL ALSO BE EFFECTIVE WITH RESPECT TO ALL OTHER CREDIT AGREEMENTS
NOW IN EFFECT BETWEEN BORROWER AND THE BANK. A MODIFICATION OF ANY OTHER CREDIT
AGREEMENTS NOW IN EFFECT BETWEEN BORROWER AND THE BANK, WHICH OCCURS AFTER
RECEIPT BY BORROWER OF THIS NOTICE, MAY BE MADE ONLY BY ANOTHER WRITTEN
INSTRUMENT. ORAL OR IMPLIED MODIFICATIONS TO SUCH CREDIT AGREEMENTS ARE NOT
ENFORCEABLE AND SHOULD NOT BE RELIED UPON.

  23. Waiver of Jury Trial. THE BORROWER AND THE BANK HEREBY JOINTLY AND
SEVERALLY WAIVE ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY ACTION OR PROCEEDING
RELATING TO ANY OF THE LOAN DOCUMENTS, THE OBLIGATIONS THEREUNDER, ANY
COLLATERAL SECURING THE OBLIGATIONS, OR ANY TRANSACTION ARISING THEREFROM OR
CONNECTED THERETO. THE BORROWER AND THE BANK EACH REPRESENTS TO THE OTHER THAT
THIS WAIVER IS KNOWINGLY, WILLINGLY AND VOLUNTARILY GIVEN.

  24. Attachments. All documents attached hereto, including any appendices,
schedules, riders, and exhibits to this Stand-Alone Revolving Note, are hereby
expressly incorporated by reference.

(Individual Borrower)        BONE CARE INTERNATIONAL, INC.
                             ---------------------------------------------------
                             Borrower Name (Organization)

                  (SEAL)     a WISCONSIN Corporation
------------------           ---------------------------------------------------

Borrower Name      N/A       By /s/ Robert A. Beckman
------------------------     ---------------------------------------------------

                  (SEAL)     Name and Title Robert A. Beckman, Acting VP Finance
------------------           ---------------------------------------------------

                             By
                             ---------------------------------------------------

Borrower Name      N/A       Name and Title
------------------------     ---------------------------------------------------

Borrower Address: ONE SCIENCE CT. MADISON, WI 53711-1055
                  --------------------------------------------------------------

Borrower Telephone No.: 608-236-2500
                        ----------------

ACKNOWLEDGE:
FIRSTAR BANK, N.A.
By: /s/ Douglas A. Rahn, Jr., V.P.
Douglas A. Rahn, Jr., Vice President

                                  Page 4 of 4

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