Document:

Amended and Restated Stock Incentive Plan

 Exhibit 10.1 

AMENDED AND RESTATED STOCK INCENTIVE PLAN 

OF VICAL INCORPORATED 

SECTION 1. ESTABLISHMENT AND PURPOSE. 

The Plan was adopted on October 14, 1992. The Plan was amended and restated effective as of January 7, 1993, was amended and
restated effective as of December 4, 1996, was amended and restated effective March 11, 1998, was amended and restated effective March 2, 1999, was amended and restated effective May 30, 2001, was amended and restated effective
June 14, 2002, was amended and restated effective May 21, 2003, was amended and restated effective May 10, 2004, was amended and restated effective March 30, 2006, was amended and restated effective May 19, 2006, was amended
and restated effective May 23, 2007, was amended and restated effective March 26, 2009, was amended effective May 24, 2010 and was amended and restated effective May 25, 2010. 

The purpose of the Plan is to offer Employees an opportunity to acquire a proprietary interest in the success of the Company, or to
increase such interest, by purchasing Shares of the Company’s Stock. The Plan provides both for the direct award or sale of Shares and for the grant of Options to purchase Shares. Options granted under the Plan may include NSOs as well as ISOs
intended to qualify under Section 422 of the Code. 
 The Plan is intended to comply in all respects with Rule 16b-3 (or
its successor) under the Exchange Act and shall be construed accordingly. 
 SECTION 2. DEFINITIONS. 

(a) “Board of Directors” shall mean the Board of Directors of the Company, as constituted from time to time. 

(b) “Change in Control” shall mean the occurrence of either of the following events: 

(i) A change in the composition of the Board of Directors, as a result of which fewer than one-half of the incumbent directors are
directors who either: 
 (A) Had been directors of the Company 24 months prior to such change; or 

(B) Were elected, or nominated for election, to the Board of Directors with the affirmative votes of at least a majority of the
directors who had been directors of the Company 24 months prior to such change and who were still in office at the time of the election or nomination; or (ii) Any “person” (as such term is used in Sections 13(d) and 14(d) of the
Exchange Act) by the acquisition or aggregation of securities is or becomes the beneficial owner, directly or indirectly, of securities of the Company representing 50 percent or more of the combined voting power of the Company’s then
outstanding securities ordinarily (and apart from rights accruing under special circumstances) having the right to vote at elections of directors (the “Base Capital Stock”); except that any change in the relative beneficial ownership of
the Company’s securities by any person resulting solely from a reduction in the aggregate number of outstanding shares of Base Capital Stock, and any decrease thereafter in such person’s ownership of securities, shall be disregarded until
such person increases in any manner, directly or indirectly, such person’s beneficial ownership of any securities of the Company. 

(c) “Code” shall mean the Internal Revenue Code of 1986, as amended. 

(d) “Committee” shall mean a committee of the Board of Directors, as described in Section 3(a). 

(e) “Common-Law Employee” means an individual paid from W-2 Payroll of the Company or a Subsidiary. If, during any period, the
Company (or a Subsidiary, as applicable) has not treated an individual as a Common-Law Employee and, for that reason, has not withheld employment taxes with respect to him or her, then that individual shall not be an Employee for that period, even
if any person, court of law or government agency determines, retroactively, that individual is or was a Common-Law Employee during all or any portion of that period. 

 (f) “Company” shall mean Vical Incorporated, a Delaware corporation. 

(g) “Employee” shall mean (i) any individual who is a Common-Law Employee of the Company or of a Subsidiary or (ii) an
Outside Director and (iii) a consultant or adviser who provides services to the Company or a Subsidiary as an independent contractor. Service as an Outside Director or as an independent contractor shall be considered employment for all purposes
of the Plan except as provided in Section 4(b). 
 (h) “Exchange Act” shall mean the Securities Exchange Act of 1934,
as amended. 
 (i) “Exercise Price” shall mean the amount for which one Share may be purchased upon exercise of an option,
as specified by the Committee in the applicable Stock Option Agreement. 
 (j) “Fair Market Value” shall mean the market
price of Stock, determined by the Committee as follows: 
 (i) If Stock was traded over-the-counter on the date in question
then the Fair Market Value shall be equal to the mean between the last reported representative bid and asked prices quoted for such date by the principal automated inter-dealer quotation system on which Stock is quoted; 

(ii) If Stock was traded on a stock exchange on the date in question, then the Fair Market Value shall be equal to the closing price
reported by the applicable composite transactions report for such date; and 
 (iii) If none of the foregoing provisions is
applicable, then the Fair Market Value shall be determined by the Committee in good faith on such basis as it deems appropriate. Whenever possible, the determination of Fair Market Value by the Committee shall be based on the prices reported in the
Western Edition of THE WALL STREET JOURNAL. Such determination shall be conclusive and binding on all persons. 
 (k) “Incentive
Stock Option” or “ISO” shall mean an employee incentive stock option described in Section 422(b) of the Code. 

(l) “Nonstatutory Option” or “NSO” shall mean an employee stock option not described in Sections 422(b) or 423(b)
of the Code. 
 (m) “Offeree” shall mean an individual to whom the Committee has offered the right to acquire Shares under
the Plan (other than upon exercise of an Option). 
 (n) “Option” shall mean an ISO or NSO granted under the Plan and
entitling the holder to purchase Shares. 
 (o) “Optionee” shall mean an individual who holds an Option. 

(p) “Outside Director” shall mean a member of the Board of Directors who is not a Common-Law Employee of the Company or of a
Subsidiary. 
 (q) “Plan” shall mean this Stock Incentive Plan of Vical Incorporated, formerly the 1992 Stock Plan of
Vical Incorporated. 
 (r) “Purchase Price” shall mean the consideration for which one Share may be acquired under the
Plan (other than upon exercise of an Option), as specified by the Committee. 
 (s) “Service” shall mean service as an
Employee. 
 (t) “Share” shall mean one share of Stock, as adjusted in accordance with Section 9 (if applicable).

 (u) “Stock” shall mean the Common Stock ($.01 par value) of the Company. 

(v) “Stock Option Agreement” shall mean the agreement between the Company and an Optionee, which contains the terms, conditions and
restrictions pertaining to the Optionee’s Option. 
 (w) “Stock Purchase Agreement” shall mean the agreement between
the Company and an Offeree who acquires Shares under the Plan, which contains the terms, conditions and restrictions pertaining to the acquisition of such Shares. 

 (x) “Subsidiary” shall mean any corporation if the Company and/or one or more other
Subsidiaries own not less than 50 percent of the total combined voting power of all classes of outstanding stock of such corporation. A corporation that attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered
a Subsidiary commencing as of such date. 
 (y) “Total and Permanent Disability” shall mean that the Optionee is unable to
engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted, or can be expected to last, for a continuous period of not less than one
year. 
 (z) “W-2 Payroll” shall mean whatever mechanism or procedure that the Company or a Subsidiary utilizes to pay any
individual which results in the issuance of a Form W-2 to the individual. “W-2 Payroll” does not include any mechanism or procedure which results in the issuance of any form other than a Form W-2 to an individual, including, but not
limited to, any Form 1099 which may be issued to an independent contractor, an agency employee or a consultant. Whether a mechanism or procedure qualifies as a “W-2 Payroll” shall be determined in the absolute discretion of the Company (or
Subsidiary, as applicable), and the Company or Subsidiary determination shall be conclusive and binding on all persons. 
 SECTION
3. ADMINISTRATION. 
 (a) Committee Composition. The Plan shall be administered by the Committee. Except as provided below,
the Committee shall consist exclusively of directors of the Company, who shall be appointed by the Board. In addition, the composition of the Committee shall satisfy: 

(i) Such requirements, if any, as the Securities and Exchange Commission may establish for administrators acting under plans intended
to qualify for exemption under Rule 16b-3 (or its successor) under the Exchange Act; and 
 (ii) Such requirements as the
Internal Revenue Service may establish for outside directors acting under plans intended to qualify for exemption under Section 162(m)(4)(C) of the Code. 

The Board may act on its own behalf with respect to Outside Directors and may also appoint one or more separate committees composed of
one or more officers of the Company, who need not be directors of the Company and who need not satisfy the foregoing requirements, who may administer the Plan with respect to Employees who are not “covered employees” under
Section 162(m)(3) of the Code and who are not required to report pursuant to Section 16(a) of the Exchange Act. 

(b) Committee Responsibilities. The Committee shall (i) select the Employees who are to receive Options and other rights to acquire
shares under the Plan, (ii) determine the type, number, vesting requirements and other features and conditions of such Options or other rights, (iii) interpret the Plan and (iv) make all other decisions relating to the operation of
the Plan. The Committee may adopt such rules or guidelines as it deems appropriate to implement the Plan. The Committee’s determinations under the Plan shall be final and binding on all persons. 

SECTION 4. ELIGIBILITY. 

(a) General Rules. Only Employees (including, without limitation, independent contractors who are not members of the Board) shall be eligible
for designation as Optionees or Offerees by the Committee. 
 (b) Incentive Stock Options. Only Employees who are Common-Law
Employees of the Company or a Subsidiary shall be eligible for the grant of ISOs. In addition, an Employee who owns more than 10% of the total combined voting power of all classes of outstanding stock of the Company or any of its Subsidiaries shall
not be eligible for the grant of an ISO unless the requirements set forth in Section 422(c)(5) of the Code are satisfied. 
 SECTION
5. STOCK SUBJECT TO PLAN. 
 (a) Basic Limitation. Shares offered under the Plan shall be authorized but unissued Shares or
treasury Shares. The aggregate number of Shares which may be issued under the Plan (upon exercise of Options or other rights to acquire Shares) shall not exceed 12,700,000 Shares (subject to adjustment pursuant to Section 9). Of the

 
Shares available hereunder, no more than 30% in the aggregate shall be available with respect to Outside Directors, subject to adjustment pursuant to Section 9. The number of Shares that are
subject to Options or other rights outstanding at any time under the Plan shall not exceed the number of Shares that then remain available for issuance under the Plan. The Company, during the term of the Plan, shall at all times reserve and keep
available sufficient Shares to satisfy the requirements of the Plan. Notwithstanding any other provision of the Plan, no Employee shall receive a grant of more than 1,300,000 Shares in any calendar year; provided that Shares subject to awards which
are not Options and which do not vest upon the satisfaction of performance goals shall be excluded from such limitation. 

(b) Additional Shares. In the event that any outstanding option or other right for any reason expires or is canceled or otherwise terminated,
the Shares allocable to the unexercised portion of such Option or other right shall again be available for the purposes of the Plan. In the event that Shares issued under the Plan are reacquired by the Company pursuant to any forfeiture provision,
right of repurchase or right of first refusal, such Shares shall again be available for the purposes of the Plan, provided, however, that no such reacquired Shares may be used for the grant of an ISO. 

SECTION 6. TERMS AND CONDITIONS OF AWARDS OR SALES. 

(a) Stock Purchase Agreement. Each award or sale of Shares under the Plan (other than upon exercise of an option) shall be evidenced by a
Stock Purchase Agreement between the Offeree and the Company. Such award or sale shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions which are not inconsistent with the Plan and
which the Committee deems appropriate for inclusion in a Stock Purchase Agreement. The provisions of the various Stock Purchase Agreements entered into under the Plan need not be identical. 

(b) Duration of Offers and Non-Transferability of Rights. Any right to acquire Shares under the Plan (other than an Option) shall
automatically expire if not exercised by the Offeree within 30 days after the grant of such right was communicated to the Offeree by the Committee. Such right shall not be transferable and shall be exercisable only by the Offeree to whom such right
was granted. 
 (c) Purchase Price. The Purchase Price of Shares to be offered under the Plan shall not be less than the par value
of such Shares. Subject to the preceding sentence, the Purchase Price shall be determined by the Committee in its sole discretion. The Purchase Price shall be payable in a form described in Section 8. 

(d) Withholding Taxes. As a condition to the purchase of Shares, the Offeree shall make such arrangements as the Committee may require for
the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with such purchase. The Committee may permit the Offeree to satisfy all or part of his or her tax obligations related to such Shares by
having the Company withhold a portion of any Shares that otherwise would be issued to him or her or by surrendering any Shares that previously were acquired by him or her. The Shares withheld or surrendered shall be valued at their Fair Market Value
on the date when taxes otherwise would be withheld in cash. The payment of taxes by assigning Shares to the Company, if permitted by the Committee, shall be subject to such restrictions as the Committee may impose, including any restrictions
required by rules of the Securities and Exchange Commission. 
 (e) Restrictions on Transfer of Shares. Any Shares awarded or sold
under the Plan shall be subject to such special forfeiture conditions, rights of repurchase, rights of first refusal and other transfer restrictions as the Committee may determine. Such restrictions shall be set forth in the applicable Stock
Purchase Agreement and shall apply in addition to any restrictions that may apply to holders of Shares generally. 
 (f) Effect of
Change in Control. The Committee may set forth in an Offeree’s Stock Purchase Agreement, or in any subsequent written agreement between the Company and the Offeree, terms upon which the Shares shall become fully vested on an accelerated
basis in the event that a Change in Control occurs with respect to the Company; provided, however, that in the absence of any such terms, no such acceleration shall occur with respect to the Shares. 

 SECTION 7. TERMS AND CONDITIONS OF OPTIONS. 

(a) Stock Option Agreement. Each grant of an Option under the Plan shall be evidenced by a Stock Option Agreement between the Optionee and the
Company. Such Option shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions which are not inconsistent with the Plan and which the Committee deems appropriate for inclusion in a Stock
Option Agreement. The Stock Option Agreement shall specify whether the Option is an ISO or an NSO. The provisions of the various Stock Option Agreements entered into under the Plan need not be identical. 

(b) Number of Shares. Each Stock Option Agreement shall specify the number of Shares that are subject to the Option and shall provide for the
adjustment of such number in accordance with Section 9. 
 (c) Exercise Price. Each Stock Option Agreement shall specify the
Exercise Price; provided that the Exercise Price shall in no event be less than 100% of the Fair Market Value of a Share on the date of grant (except as a higher percentage may be required by Section 4(b)). Subject to the preceding sentence,
the Exercise Price under any Option shall be determined by the Committee at its sole discretion. The Exercise Price shall be payable in a form described in Section 8. 

(d) Withholding Taxes. As a condition to the exercise of an Option, the Optionee shall make such arrangements as the Committee may require
for the satisfaction of any federal, state, local or foreign withholding tax obligations that may arise in connection with such exercise. The Optionee shall also make such arrangements as the Committee may require for the satisfaction of any
federal, state, local or foreign withholding tax obligations that may arise in connection with the disposition of Shares acquired by exercising an Option. The Committee may permit the Optionee to satisfy all or part of his or her tax obligations
related to the Option by having the Company withhold a portion of any Shares that otherwise would be issued to him or her or by surrendering any Shares that previously were acquired by him or her. Such Shares shall be valued at their Fair Market
Value on the date when taxes otherwise would be withheld in cash. The payment of taxes by assigning Shares to the Company, if permitted by the Committee, shall be subject to such restrictions as the Committee may impose, including any restrictions
required by rules of the Securities and Exchange Commission. 
 (e) Exercisability. Each Stock Option Agreement shall specify the
date when all or any installment of the Option is to become exercisable. The vesting of any Option shall be determined by the Committee at its sole discretion. A Stock Option Agreement may provide for accelerated exercisability in the event of the
Optionee’s death, Total and Permanent Disability, retirement or other events. 
 (f) Effect of Change in Control. The Committee
may set forth in an Optionee’s Stock Option Agreement, or in any subsequent written agreement between the Company and the Optionee, terms upon which the Option grant shall become exercisable on an accelerated basis n the event that a Change in
Control occurs with respect to the Company provided, however, that in the absence of any such terms, no such acceleration shall occur with respect to the Option. 

(g) Term. The Stock Option Agreement shall specify the term of the Option. The term shall not exceed 10 years from the date of grant, except
as otherwise provided in Section 4(b). Subject to the preceding sentence, the Committee at its sole discretion shall determine when an Option is to expire. 

(h) Non-Transferability. An option granted under the Plan shall not be anticipated, assigned, attached, garnished, optioned, transferred or
made subject to any creditor’s process, whether voluntarily, involuntarily or by operation of law, except as approved by the Committee. Notwithstanding the foregoing, ISOs may not be transferable. However, this Section 7 shall not preclude
an Optionee from designating a beneficiary who will receive any outstanding Options in the event of the Optionee’s death, nor shall it preclude a transfer of Options by will or by the laws of descent and distribution. 

(i) Termination of Service (except by death). If an Optionee’s Service terminates for any reason other than the Optionee’s death,
then the Optionee’s Option(s) shall, except to the extent determined by the Committee, expire on the earliest of the following occasions: 

(i) The expiration date determined pursuant to Subsection (g) above; 

 (ii) The date 90 days (or such longer or shorter period as provided in Optionee’s
Stock Option Agreement) after the termination of the Optionee’s Service for any reason other than Total and Permanent Disability; or 

(iii) The date six months after the termination of the Optionee’s Service by reason of Total and Permanent Disability.

 The Optionee may exercise all or part of the Optionee’s Option(s) at any time before the expiration of such Option(s)
under the preceding sentence, but only to the extent that such Option(s) had become exercisable before the Optionee’s Service terminated. The balance of such Option(s) shall lapse when the Optionee’s Service terminates. In the event that
the Optionee dies after the termination of the Optionee’s Service but before the expiration of the Optionee’s Option(s), all or part of such Option(s) may be exercised (prior to expiration) by the executors or administrators of the
Optionee’s estate or by any person who has acquired such Option(s) directly from the Optionee by bequest, beneficiary designation or inheritance, but only to the extent that such Option(s) had become exercisable before the Optionee’s
Service terminated. 
 (j) Leaves of Absence. For purposes of Subsection (i) above, Service shall, except to the extent
determined by the Committee, be deemed to continue while the Optionee is on military leave, sick-leave or other bona fide leave of absence (as determined by the Committee). The foregoing notwithstanding, in the case of an ISO granted under the Plan,
Service shall not be deemed to continue beyond the first 90 days of such leave, unless the Optionee’s reemployment rights are guaranteed by statute or by contract. 

(k) Death of Optionee. If an Optionee dies while the Optionee is in Service, then the Optionee’s Option(s) shall, except to the extent
determined by the Committee, expire on the earlier of the following dates: 
 (i) The expiration date determined pursuant to
Subsection (g) above; or 
 (ii) The date six months (or such longer or shorter period as provided in Optionee’s
Stock Option Agreement) after the Optionee’s death. 
 All or part of the Optionee’s Option(s) may be exercised at any
time before the expiration of such Option(s) under the preceding sentence by the executors or administrators of the Optionee’s estate or by any person who has acquired such Option(s) directly from the Optionee by bequest, beneficiary
designation or inheritance, but only to the extent that such Option(s) had become exercisable before the Optionee’s death. The balance of such Option(s) shall lapse when the Optionee dies. 

(l) No Rights as a Stockholder. An Optionee, or a transferee of an Optionee, shall have no rights as a stockholder with respect to any Shares
covered by the Optionee’s Option until such person is entitled, pursuant to the terms of such Option, to receive such Shares. No adjustments shall be made, except as provided in Section 9. 

(m) Modification, Extension and Assumption of Options. Within the limitations of the Plan, the Committee may modify, extend or assume
outstanding Options; provided that the Committee may not (i) amend the Exercise Price of outstanding Options granted by the Company, (ii) accept the cancellation of outstanding Options granted by the Company in return for the grant of new
Options for the same or a different number of Shares and at the same or a different Exercise Price or (iii) accept in return for cash payments the cancellation of outstanding Options granted by the Company having an Exercise Price greater than
the then existing Fair Market Value. The foregoing notwithstanding, no modification of an Option shall, without the consent of the Optionee, impair the Optionee’s rights or increase the Optionee’s obligations under such Option. 

(n) Restrictions on Transfer of Shares. Any Shares issued upon exercise of an Option shall be subject to such special forfeiture conditions,
rights of repurchase, rights of first refusal and other transfer restrictions as the Committee may determine. Such restrictions shall be set forth in the applicable Stock Option Agreement and shall apply in addition to any restrictions that may
apply to holders of Shares generally. 
 SECTION 8. PAYMENT FOR SHARES. 

(a) General Rule. The entire Purchase Price or Exercise Price of Shares issued under the Plan shall be payable in lawful money of the United
States of America at the time when such Shares are purchased, except as provided in Subsections (b), (c), (d) and (e) below. The foregoing notwithstanding, no portion of the Exercise Price or Purchase Price (as the case may be) of Shares
issued under the Plan may be paid with a promissory note. 

 (b) Surrender of Stock. To the extent that a Stock Option Agreement so provides, payment may be
made all or in part with Shares which have already been owned by the Optionee or the Optionee’s representative for more than six months and which are surrendered to the Company in good form for transfer. Such Shares shall be valued at their
Fair Market Value on the date when the new Shares are purchased under the Plan. 
 (c) [Reserved]. 

(d) Exercise/Sale. To the extent that a Stock Option Agreement so provides, payment may be made all or in part by the delivery (on a form
prescribed by the Company) of an irrevocable direction to a securities broker approved by the Company to sell Shares and to deliver all or part of the sales proceeds to the Company in payment of all or part of the Exercise Price and any withholding
taxes. 
 (e) Exercise/Pledge. To the extent that a Stock Option Agreement so provides, payment may be made all or in part by the
delivery (on a form prescribed by the Company) of an irrevocable direction to pledge Shares to a securities broker or lender approved by the Company, as security for a loan, and to deliver all or part of the loan proceeds to the Company in payment
of all or part of the Exercise Price and any withholding taxes. 
 SECTION 9. ADJUSTMENT OF SHARES. 

(a) General. In the event of a subdivision of the outstanding Stock, a declaration of a dividend payable in Shares, a declaration of a
dividend payable in a form other than Shares in an amount that has a material effect on the value of Shares, a combination or consolidation of the outstanding Stock into a lesser number of Shares, a recapitalization, a spinoff, a reclassification or
a similar occurrence, the Committee shall make appropriate adjustments in one or more of (i) the number of Shares available for future grants under Section 5a, (ii) the number of Shares covered by each outstanding Option or
(iii) the Exercise Price under each outstanding Option. 
 (b) Mergers and Consolidations. In the event that the Company is a
party to a merger or consolidation, outstanding Options shall be subject to the agreement of merger or consolidation. Such agreement may provide for the assumption of outstanding Options by the surviving corporation or its parent or for their
continuation by the Company (if the Company is the surviving corporation). In the event the Company is not the surviving corporation and the surviving corporation will not assume the outstanding Options, the agreement of merger or consolidation may
provide for payment of a cash settlement for exercisable options equal to the difference between the amount to be paid for one Share under such agreement and the Exercise Price and for the cancellation of Options not exercised or settled, in either
case without the Optionees’ consent. 
 (c) Reservation of Rights. Except as provided in this Section 9, an Optionee or
Offeree shall have no rights by reason of (i) any subdivision or consolidation of shares of stock of any class, (ii) the payment of any dividend or (iii) any other increase or decrease in the number of shares of stock of any class.
Any issue by the Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall not affect, and no adjustment by reason thereof shall be made with respect to, the number or Exercise Price of Shares
subject to an Option. The grant of an Option pursuant to the Plan shall not affect in any way the right or power of the Company to make adjustments, reclassifications, reorganizations or changes of its capital or business structure, to merge or
consolidate or to dissolve, liquidate, sell or transfer all or any part of its business or assets. 
 SECTION 10. SECURITIES LAWS. 

 Shares shall not be issued under the Plan unless the issuance and delivery of such Shares comply with (or are exempt from) all
applicable requirements of law, including (without limitation) the Securities Act of 1933, as amended, the Exchange Act, the rules and regulations promulgated thereunder, state securities laws and regulations, and the regulations of any stock
exchanges on which the Company’s securities may then be listed. 
 SECTION 11. NO EMPLOYMENT RIGHTS. 

No provision of the Plan, nor any right or Option granted under the Plan, shall be construed to give any person any right to become, to be
treated as, or to remain an Employee. The Company and its Subsidiaries reserve the right to terminate any person’s Service at any time and for any reason. 

 SECTION 12. DURATION AND AMENDMENTS. 

(a) Term of the Plan. The Plan, as set forth herein, shall become effective as of the date indicated herein. The Plan shall terminate
automatically 10 years after its amendment and restatement by the Board of Directors to read as set forth herein and may be terminated on any earlier date pursuant to Subsection (b) below. 

(b) Right to amend or Terminate the Plan. The Board of Directors may at any time and for any reason, amend, suspend or terminate the Plan. An
amendment of the Plan shall be subject to the approval of the Company’s stockholders only to the extent required by applicable laws, regulations and rules, including the rules of any applicable exchange. 

(c) Effect of Amendment or Termination. No Shares shall be issued or sold under the Plan after the termination thereof, except upon
(i) the exercise of an Option granted prior to such termination or (ii) the issuance of Shares pursuant to a Stock Purchase Agreement executed prior to such termination. The termination of the Plan, or any amendment thereof, shall not
affect any Share previously issued or any Option previously granted under the Plan. 
 SECTION 13. EXECUTION. 

To record the amendment and restatement of the Plan by the Board of Directors, effective May 25, 2010, the Company has caused its
authorized officer to execute the same. 
  

			
	VICAL INCORPORATED
		
	By:	 	 /s/ Vijay B. SamantFirst Amendment

 Exhibit 10.19.1 

FIRST AMENDMENT TO AMENDED AND RESTATED  

LOAN AND SECURITY AGREEMENT 

This First Amendment to Amended and Restated Loan and Security Agreement (“Amendment”) is dated as of July 1, 2010,
by and among C&F FINANCE COMPANY and such other Persons joined to the Loan Agreement as Borrowers from time to time (collectively, the “Borrowers” and each a “Borrower”), WELLS FARGO PREFERRED CAPITAL, INC., as
agent for Lenders (in such capacity, “Agent”), and the financial institutions a party hereto as lenders (collectively, the “Lenders” and each is a “Lender”). 

BACKGROUND 

A. Borrowers, Lenders and Agent are parties to a certain Amended and Restated Loan and Security Agreement dated as of August 25,
2008 (as amended or modified from time to time, the “Loan Agreement”). Capitalized terms used but not otherwise defined in this Amendment shall have the meanings respectively ascribed to them in the Loan Agreement. 

B. Borrowers have requested and Agent and Lenders have agreed to amend the Loan Agreement in certain respects, all on the terms and
conditions set forth herein. 
 NOW, THEREFORE, the parties hereto, intending to be legally bound, hereby promise and agree as
follows: 
 1. Amendments. Upon the effectiveness of this Amendment, the Loan Agreement shall be amended as follows:

 (a) New Definitions. The following new definitions are hereby added to Section 1.1 of the Loan Agreement as
follows: 
 “Advance Rate” means the following percentage based upon the Collateral Performance Indicator as of
the end of each month then most recently ended for which monthly reports have been delivered to Agent pursuant to Section 6.2 (it being acknowledged that as of the date hereof, the Advance Rate is 85%): 

 

				
	 Collateral Performance Indicator
	  	Advance
Rate	 
	 Less than 9%
	  	85	% 
		
	 Greater than or equal to 9% but less than 11%
	  	84	% 
		
	 Greater than or equal to 11% but less than 13%
	  	83	% 
		
	 Greater than or equal to 13% but less than 15%
	  	82	% 
		
	 Greater than or equal to 15%
	  	81	% 

 “Applicable Margin” shall mean (a) initially, 2.00% and
(b) commencing with Agent’s receipt of the monthly financial statements and other documentation and reports required pursuant to Section 6.2 for the calendar month ending May 31, 2010, the following percentage as set forth in the
matrix below (no downward rate adjustment being permitted if an Event of Default or Default is outstanding): 
  

			
	 EBITDA Ratio
	  	 Applicable
Margin

	 Less than 1.65 to 1.0
	  	225 basis points
	 Greater than or equal to 1.65 to 1.0
	  	200 basis points

 For
purposes of the foregoing (i) the Applicable Margin shall be adjusted monthly in accordance with the matrix above, based upon Agent’s receipt of monthly financial statements and other documentation and reports required pursuant to
Section 6.2, and effective the 1st day of the month of the delivery of such financial statements and other documentation and reports and (ii) if Borrowers fail to timely deliver the applicable financial statements, documentation and
reports or any other Event of Default then exists, then at Agent’s option, the Applicable Margin will be increased to the highest rate of interest pursuant to the above matrix, which rate of interest shall continue in effect until the
applicable financial statements are delivered. In the event that any financial statement, covenant compliance certificate, documentation and reports delivered pursuant to Section 6.2 is shown to be inaccurate (regardless of whether this
Agreement is in effect when such inaccuracy is discovered), and such inaccuracy, if corrected, would have led to the application of a higher Applicable Margin for any period (an “Applicable Period”) than the Applicable Margin
applied for such Applicable Period, and only in such case, then Borrowers shall immediately (i) deliver to Agent a corrected covenant compliance certificate for such Applicable Period, (ii) determine the Applicable Margin for such
Applicable Period based upon the corrected covenant compliance certificate, and (iii) immediately pay to Agent, for the benefit of Lenders, the accrued additional interest owing as a result of such increased Applicable Margin for such
Applicable Period. 
 “Collateral Performance Indicator” means as of the end of each testing period the sum of:

 (a) the 61+ day delinquency percentage (the percentage defined as (x) Receivables for which payment is 61
or more days contractually past due, divided by (y) total Receivables at such date), plus 
  

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 (b) (i) net charge-offs for the 12 month period ending on such date
divided by (ii) average Principal Receivables during the 12 month period ending on such date. 
 “First
Amendment” shall mean that certain First Amendment to Amended and Restated Loan and Security Agreement by and among Borrowers, Agent and Lenders dated July 1, 2010. 

“Permitted Lien” shall mean the junior subordinated Lien granted by Borrowers to Citizens and Farmers Bank to secure the
Subordinated Debt owing to Citizens and Farmers Bank pursuant to the Citizens and Farmers Subordinated Debt Documents (as defined in the First Amendment); provided, however, the maximum amount of Subordinated Debt secured by such Lien shall not at
any time exceed $36,000,000. 
 “Principal Receivables” means as of the date of determination Receivables, net
of unearned finance charges and insurance commissions. 
 (b) Definitions. The following definitions contained in
Section 1.1 of the Loan Agreement are hereby amended and restated in their entirety as follows: 
 “Borrowing
Base” means, as of the date of determination and subject to change from time to time as described below, an amount equal to the Advance Rate multiplied by the aggregate balance of outstanding Eligible Receivables net of unearned interest,
fees, commissions, discounts and reserves. 
 “Maturity Date” means July 31, 2014, as such date may be
extended from time to time in accordance with the provisions of Section 2.4 of this Agreement. 
 (c) Interest.
Section 2.6(a) of the Loan Agreement is amended and restated in its entirety as follows: 
 (a) In the
absence of an Event of Default or Default hereunder, and prior to the Termination Date, the outstanding balance of the Loans will bear interest at an annual rate at all times equal to the LIBOR Rate plus the Applicable Margin; provided,
however, (i) if average borrowings from Lenders during any calendar month are in an amount less than $75,000,000, then the Loans shall bear interest for such calendar month at an annual rate at all times equal to the sum of (A) the LIBOR
Rate plus (B) the Applicable Margin plus (C) 25 basis points, (ii) during each period that the average outstanding principal balance of the Loan during any calendar month is less than $50,000,000 (“Minimum
Balance”), Borrowers shall pay interest for such calendar month at such rate per annum based upon the Minimum Balance; and (iii) Agent shall at all 

 

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times be entitled to retain, solely for its own account, and not remit to Lenders from such monthly interest payment an interest payment in an amount equal to interest on the outstanding balance
of the Loan at an annual rate at all times equal to 10 basis points. 
 (d) Optional Prepayments. Section 2.8(a) of
the Loan Agreement is amended and restated in its entirety as follows: 
 (a) Optional Prepayments.
Borrowers may prepay the Loan from time to time, in full or in part not to exceed $5,000,000 without notice, and, in part, in excess of $5,000,000 upon 5 Business Day’s prior notice to Agent without premium or penalty, provided that (i) in
the event Borrowers repay the Loan in full prior to the date which is six (6) months before the Maturity Date or the Obligations are accelerated prior to the date which is six (6) months before the Maturity Date, Borrower shall pay the sum
equal to 0.25% of the Commitment as a prepayment fee; (ii) prepayments shall be in a minimum amount of $10,000 and $10,000 increments in excess thereof; and (iii) partial prepayments prior to the Termination Date shall not reduce
Lenders’ Commitments under this Agreement and may be reborrowed, subject to the terms and conditions hereof for borrowing, and partial prepayments will be applied first to accrued interest and fees and then to outstanding Advances. Each
Borrower acknowledges that the above described fee is an estimate of Lenders’ damages in the event of early termination and is not a penalty. In the event of termination of the credit facility established pursuant to this Agreement, all of the
Obligations shall be immediately due and payable upon the termination date stated in any notice of termination. All undertakings, agreements, covenants, warranties and representations of Borrowers contained in the Credit Documents shall survive any
such termination, and Agent shall retain its liens in the Collateral and all of its rights and remedies under the Credit Documents notwithstanding such termination until Borrowers have paid the Obligations to Agent and Lenders, in full, in
immediately available funds, together with the applicable termination fee, if any. Notwithstanding anything to the contrary contained herein, Borrowers shall not be obligated to pay the above described prepayment fee if Borrowers repay the Loan in
full as a result of Agent making a demand for payment under Section 2.10 hereof and Borrowers have not exercised their rights under Section 2.14 hereof as a result of such demand. 

(e) Financial Covenants. Effective as the calendar month ending June 30, 2010, Section 6.4 of the Loan Agreement is
amended and restated in its entirety as follows: 
 Section 6.4 Financial Covenants. At all times
Borrowers shall maintain the following financial covenants (based on consolidated financial statements of Borrowers and their consolidated Subsidiaries unless otherwise indicated): 

(a) EBITDA Ratio. As of the end of each calendar month, an EBITDA Ratio of not less than 1.50 to 1. 

 

 4 

 (b) Collateral Performance Indicator. At all times the Collateral
Performance Indicator shall be less than 17%. 
 (c) Allowance for Loan Losses. At all times the aggregate
value of Borrowers’ allowance for loan losses, as calculated in accordance with GAAP, in an amount not less than the greater of (a) 5.0% of the total net outstanding Receivables or (b) net outstanding Receivables multiplied by the rolling
twelve month ratio of the net charge-offs to average net Receivables outstanding during such twelve month period or (c) an amount pursuant to the recommendation of the independent certified public accountant auditing Borrowers’ financial
statements. 
 (d) Senior Debt to Capital Base Ratio. At all times, a ratio of Senior Debt to Capital Base
of not more than 3.25 to 1.0. 
 (e) Charge-off Policy. Receivables must be charged off (on a monthly
basis) with respect to which no payment due and owing thereunder hereunder has been made for a period that is equal to or greater than 180 days, as determined on a contractual basis. 

Borrowers’ failure to comply with Section 6.4(c) or Section 6.4(e) shall not, in itself, constitute an Event of Default so
long as such shortfalls or losses are deducted, as contemplated by the terms of this Agreement, in the determination of the other financial covenants contained herein. 

(f) Indebtedness. Section 7.3 of the Loan Agreement is amended and restated in its entirety as follows 

Section 7.3 Indebtedness. Borrow any monies or create any Debt except: (a) borrowings from Agent and
Lenders hereunder; (b) Subordinated Debt; (c) trade indebtedness in the normal and ordinary course of business for value received; (d) indebtedness and obligations incurred to purchase or lease fixed or capital assets; (e) unsecured
indebtedness and obligations owing to Citizens and Farmers Bank and (f) Bank Products. 
 (g) Negative Pledge.
Section 7.6 of the Loan Agreement is amended and restated in its entirety as follows: 
 Section 7.6
Negative Pledge. Assign, discount, pledge, sell, grant a Lien in or otherwise dispose of or encumber any 
  

 5 

 
Receivables or the Collateral except (i) as contemplated by this Agreement and (ii) the Permitted Lien. Notwithstanding the foregoing, Borrowers shall be permitted to sell Receivables
in an amount not to exceed Five Million Dollars ($5,000,000.00) per fiscal quarter and Agent shall release its interest in such Receivables, provided, that (i) Borrowers provide Agent and Lenders with at least ten days prior
written notice of any sale of Receivables, (ii) no Default or Event of Default has occurred and is continuing and (iii) the proceeds of such sale are paid directly to Agent by wire transfer to be applied against the Obligations, as
determined by Agent, in its sole and absolute discretion. 
 (h) Subordinated Debt. For the avoidance of doubt,
Subordinated Debt shall include the Additional Subordinated Debt, and any reference in the Loan Agreement or any other Credit Document to Subordinated Debt shall include the Additional Subordinated Debt. 

2. Consent — Additional Subordinated Debt. 

(a) Borrowers have advised Agent that they intend to (i) incur Thirty Million Dollars ($30,000,000) of additional Subordinated Debt
from Citizens and Farmers Bank on a secured basis (the “Additional Subordinated Debt”) and (ii) grant liens to Citizens and Farmers Bank to secure the existing Six Million Dollars ($6,000,000) of Subordinated Debt owing to
Citizens and Farmers Bank (the “Existing Subordinated Debt”), pursuant to the documents, instruments and agreements attached hereto as Exhibit I (collectively, the “Citizens and Farmers Subordinated Debt
Documents”). Borrowers have agreed not to incur any Debt, grant any Liens or amend any documents evidencing the Subordinated Debt other than as expressly permitted under the Loan Agreement. In the absence of a written consent by Lenders as
to Borrowers (i) incurring the Additional Subordinated Debt, (ii) granting Liens to secure the Additional Subordinated Debt and the Existing Subordinated Debt and (iii) entering into the Citizens and Farmers Subordinated Debt
Documents (collectively, the “Consent Events” and each individually referred to as a “Consent Event”), one or more of the Events of Default would exist under the Loan Agreement. 

(b) In reliance upon the representations and warranties contained herein and the documentation and information provided to Agent and
Lenders regarding the Additional Subordinated Debt, the Existing Subordinated Debt and the Citizens and Farmers Subordinated Debt Documents, upon the effectiveness of this Amendment, Agent and Lenders consent to each Consent Event. 

(c) This consent shall be effective only as to the Consent Events. This consent shall not be deemed a consent to the breach by Borrowers
of other covenants or agreements contained in any Credit Document with respect to any other transaction or matter. Borrowers agree that the consent set forth in the preceding paragraph shall be limited to the precise meaning of the words as written
therein and shall not be deemed (i) to be a consent to any waiver or modification of any other term or condition of any Credit Document, or (ii) to prejudice any right or remedy that Agent or any Lender may now have or may in the future
have or in connection with any Credit Document other than with respect to the matters for which the consent in the preceding paragraph has been provided. Except as expressly set forth herein, the consent described in the preceding paragraph shall
not alter, affect, release or prejudice in any way any of Borrowers’ obligations under the Credit Documents (including, without limitation, the Obligations). 

 

 6 

 3. Effectiveness Conditions. This Amendment shall be effective upon the completion of
the following conditions precedent (all agreements, documents and instruments to be in form and substance satisfactory to Agent and Agent’s counsel): 

(a) Execution and delivery by Borrowers and Lenders of this Amendment to Agent; 

(b) Execution and delivery of the Second Amended and Restated Subordination Agreement by and among Citizens and Farmers Bank, Borrowers
and Agent; 
 (c) Receipt by Agent of the fully executed Citizens and Farmers Subordinated Debt Documents; 

(d) Delivery to Agent of a certified copy of resolutions of each Borrower’s directors, members or managers, as applicable,
authorizing the execution, delivery and performance of this Amendment and the Citizens and Farmers Subordinated Debt Documents; and 

(e) Execution and/or delivery by the parties of all other agreements, instruments and documents requested by Agent to effectuate and
implement the terms hereof and the Credit Documents. 
 4. Representations and Warranties. Each Borrower represents and
warrants to Agent and Lenders that: 
 (a) All warranties and representations made to Agent under the Loan Agreement and the
Credit Documents are true and correct as to the date hereof. 
 (b) The execution and delivery by Borrowers of this Amendment
and the performance by each of them of the transactions herein contemplated (i) are and will be within such party’s powers, (ii) have been authorized by all necessary organizational action, and (iii) are not and will not
(1) be in contravention of any order of any court or other agency of government, of law or any other indenture, agreement or undertaking to which Borrowers, or any of them, is a party or by which the property of Borrowers, or any of them, is
bound, or (2) be in conflict with, result in a breach of, or constitute (with due notice and/or lapse of time) a default under any such indenture, agreement or undertaking or result in the imposition of any lien, charge or encumbrance of any
nature on any of the properties of Borrowers, or any of them. 
 (c) This Amendment and any assignment, instrument, document, or
agreement executed and delivered in connection herewith will be valid, binding and enforceable in accordance with its respective terms. 

(d) No Event of Default or Default has occurred under the Loan Agreement or any of the other Credit Documents. 

5. Business Operations. Each Borrower hereby agrees to continue to operate its business and operations in a manner consistent with
its past business practice, continue to meet the standards generally observed by prudent finance companies and conform to its policies as have been previously disclosed to Agent in writing. 

 

 7 

 6. Representations and Release of Claims. Except as otherwise specified herein, the
terms and provisions hereof shall in no manner impair, limit, restrict or otherwise affect the obligations of any Borrower or any third party to Agent and Lenders as evidenced by the Credit Documents. Each Borrower hereby acknowledges, agrees, and
represents that (a) as of the date of this Amendment, there are no claims or offsets against, or defenses or counterclaims to, the terms or provisions of the Credit Documents or the other obligations created or evidenced by the Credit
Documents; (b) as of the date of this Amendment, no Borrower has any claims, offsets, defenses or counterclaims arising from any of Agent’s acts or omissions with respect to the Credit Documents or Agent’s performance under the Credit
Documents; and (c) each Borrower promises to pay to the order of Agent and Lenders the indebtedness evidenced by the Notes according to the terms thereof. In consideration of the modification of certain provisions of the Credit Documents, all
as herein provided, and the other benefits received by Borrowers hereunder, each Borrower hereby RELEASES, RELINQUISHES and forever DISCHARGES Agent and Lenders, and their predecessors, successors, assigns, shareholders, principals, parents,
subsidiaries, agents, officers, directors, employees, attorneys and representatives (collectively, the “Released Parties”), of and from any and all present claims, demands, actions and causes of action of any and every kind or
character, whether known or unknown, which Borrowers, or any of them, has or may have against Released Parties arising out of or with respect to any and all transactions relating to the Loan Agreement, the Notes and the other Credit Documents
occurring prior to the date hereof. 
 7. Collateral. As security for the payment of the Obligations and satisfaction by
Borrowers of all covenants and undertakings contained in the Loan Agreement and the Credit Documents, each Borrower reconfirms the prior security interest and lien on, upon and to, its Collateral, whether now owned or hereafter acquired, created or
arising and wherever located. Borrowers each hereby confirm and agree that all security interests and Liens granted to Agent for the ratable benefit of Lenders and WFPC Affiliates continue in full force and effect and shall continue to secure the
Obligations. All Collateral remains free and clear of any Liens other than Permitted Liens. Nothing herein contained is intended to in any manner impair or limit the validity, priority and extent of Agent’s existing security interest in and
Liens upon the Collateral. 
 8. Acknowledgment of Indebtedness and Obligations. Borrowers hereby acknowledge and confirm
that, as of June 28, 2010, Borrowers are indebted to Agent and Lenders, without defense, setoff or counterclaim, under the Loan Agreement (in addition to any other indebtedness or obligations owed by Borrowers to WFPC Affiliates) in the
aggregate principal amount of $77,463,666.02, plus continually accruing interest and all fees, costs, and expenses, including reasonable attorneys’ fees, incurred through the date hereof. 

9. Ratification of Credit Documents. This Amendment shall be incorporated into and deemed a part of the Loan Agreement. Except as
expressly set forth herein, all of the terms and conditions of the Loan Agreement and Credit Documents are hereby ratified and confirmed and continue unchanged and in full force and effect. All references to the Loan Agreement shall mean the Loan
Agreement as modified by this Amendment. 
 10. APPLICABLE LAW. THIS AMENDMENT AND ALL DOCUMENTS EXECUTED IN CONNECTION
HEREWITH SHALL BE DEEMED TO HAVE BEEN 
  

 8 

 
MADE AND TO BE PERFORMABLE IN THE STATE OF IOWA AND SHALL BE GOVERNED AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF IOWA. 

11. Counterparts. This Amendment may be executed in any number of counterparts, each of which when so executed shall be deemed to
be an original, and such counterparts together shall constitute one and the same respective agreement. Signature by facsimile or PDF shall also bind the parties hereto. 

12. WAIVER OF JURY TRIAL. EACH PARTY HERETO HEREBY WAIVES TRIAL BY JURY IN ANY JUDICIAL PROCEEDING INVOLVING, DIRECTLY OR
INDIRECTLY, ANY MATTER (WHETHER SOUNDING IN TORT, CONTRACT OR OTHERWISE) IN ANY WAY ARISING OUT OF OR RELATED TO THIS AMENDMENT OR ANY CREDIT DOCUMENT OR THE RELATIONSHIP ESTABLISHED HEREUNDER. THIS PROVISION IS A MATERIAL INDUCEMENT FOR AGENT AND
LENDERS TO ENTER INTO THIS AMENDMENT. 
 [SIGNATURES ON FOLLOWING PAGES] 

 

 9 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed by their
respective duly authorized officers as of the date first above written. 
  

					
	BORROWER:	 	C&F FINANCE COMPANY
			
		 	By:	 	 /s/ Thomas Cherry

		 	Name:	 	 Thomas Cherry

		 	Title:	 	 Treasurer

[SIGNATURE PAGE TO FIRST AMENDMENT] 
  

 S-1 

					
	AGENT:	 	WELLS FARGO PREFERRED CAPITAL, INC.
			
		 	By:	 	 /s/ William M Laird

		 	Name:	 	 William M Laird

		 	Title:	 	 SVP

[SIGNATURE PAGE TO FIRST AMENDMENT] 
  

 S-2 

					
	LENDERS:	 	WELLS FARGO PREFERRED CAPITAL, INC.
			
		 	By:	 	 /s/ William M Laird

		 	Name:	 	 William M Laird

		 	Title:	 	 SVP

[SIGNATURE PAGE TO FIRST AMENDMENT] 
  

 S-3 

			
	FIRST TENNESSEE BANK, NATIONAL ASSOCIATION
		
	By:	 	 /s/ Pamela S. Sullivan

	Name:	 	 Pamela S. Sullivan

	Title:	 	 Vice President

[SIGNATURE PAGE TO FIRST AMENDMENT] 
  

 S-4

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