Document:

Lease between Galena Biopharma, Inc. and LO 138, LLC

 Exhibit 10.43 
 RXi PHARMACEUTICALS CORP. 
 2,136 rentable sq. ft. 

“LAKE VIEW VILLAGE” 
 COMMERCIAL OFFICE LEASE 
 THIS LEASE, dated as of the 30th day of
June, 2011, between LO 138 LLC, an Oregon limited liability company as “Landlord” and RXi PHARMACEUTICALS CORPORATION, a Delaware corporation, as “Tenant”. 
 Section 1 PREMISES. Landlord hereby leases to Tenant and Tenant hereby leases from Landlord approximately 2,136 rentable Square feet of space shown on the floor plan attached hereto as
Exhibit A-1 (“the “Premises”) on the second floor of the building as shown crosshatched on the site plan attached as Exhibit A-2 (the “Building”) in the development known as Lakeview Village constructed or to be constructed
by Landlord on the real property described in attached Exhibit A-3 (the “Project”). Tenant’s lease of the Premises shall include the appurtenant right to use in common with others all common areas within the Project as Landlord may
from time to time designate. Tenant’s lease of the Premises shall also include the nonexclusive right to use in common with others the City of Lake Oswego public parking garage constructed or to be constructed as shown on the site plan attached
as Exhibit A-2 (the “Garage”). Such use shall be in accordance with the LORA Parking Facility Use, Maintenance and Operation Agreement between the Lake Oswego Redevelopment Agency and Gramor Development, Inc. (the “Parking
Agreement”). Landlord reserves the right to alter or relocate any common area. The Lease is subject to all easements, restrictions, agreements of record, mortgages and deeds of trust, and zoning and building laws. This Lease is subject to that
certain Agreement for the Disposition and Development of Block 138, City of Lake Oswego (“DDA”) dated April 17, 2001 between The Lake Oswego Redevelopment Agency (“LORA”) and Gramor Development, Inc. and any amendments
thereto 
 Section 2 TERM. The lease term shall commence on the Date of Commencement described below and continue for
twenty-four (24) full calendar months (plus the partial month, if any, in which the lease commences), unless sooner terminated. “Date of Commencement” shall be August 1, 2011. 

Section 3 RENT. 
 3.1 Minimum Rent. Tenant shall pay to Landlord, during the term of this Lease as minimum monthly rent the sum of Three Thousand Two Hundred Four and no/100 Dollars ($3,204.00) per month. Tenant
shall not be required to pay minimum rent during Month 1 of the Lease term. Tenant shall be required to pay additional rent, pursuant to Section 3.2 from the Date of Commencement. Rent will be paid in advance on the first day of each month at such
place as Landlord may designate. Minimum rent is uniformly apportionable day to day. Minimum rent for the partial month (if any) in which the lease term commences shall be prorated and paid at commencement of the lease term. Upon execution hereof,
Tenant shall pay to Landlord the sum of Three Thousand Two Hundred Four and no/100 Dollars ($3,204.00) to be applied to minimum and additional rent as it becomes due. 

 3.2 Additional Rent. 

(1) Operating Expenses. In addition to the minimum rent, Tenant shall pay as additional rent its share of all expenses for the
Project. As used herein “operating expenses” shall mean all costs of ownership, operation, maintenance and repair of the Project as determined by standard real estate accounting practice, including but not limited to: wages, salaries and
benefits of employees engaged in the operation, maintenance and repair of the Project; costs incurred by the Landlord under the Parking Agreement; the cost of all utilities for the Project including water, sewer, lighting, power, heating, air
conditioning and ventilating (excluding utilities separately metered and servicing tenant spaces exclusively); the cost of janitorial service and supplies, waste disposal service, window washing and her services furnished for the benefit of tenants
of the Project; costs of consumable supplies including without limitation cleaning supplies, restroom paper products, light bulbs, tubes and ballasts; costs of Project maintenance and service agreements; the cost of security, repair and replacement;
cost of materials, tools and equipment used in the operation, management and maintenance of the Project; common area utility costs including city or county road maintenance fees; the cost of all insurance relating to the Project, including but not
limited to the cost of casualty, rental abatement, boiler and machinery, earthquake, flood and liability insurance (and all deductibles); all accounting, legal and professional fees incurred in connection with the operation of the Project; the cost
of rental value of the Project office; and a management fee of four percent (4%) of the minimum rent 
 (2) Taxes and
Assessments. In addition to the minimum rent, Tenant shall pay as additional rent its share of all real property taxes and assessments of any public authority against the Project payable during or with respect to the Lease term, including
without limitation, Landlord’s cost incurred under the Parking Agreement and the cost of contesting any tax. Real property taxes and assessments shall include all real property taxes and assessments of any public authority assessed against the
Project and any rent tax, gross receipts tax, tax on Landlord’s interest under this Lease, or any tax in lieu of the foregoing, whether or not such tax is now in effect (excluding any tax based upon Landlord’s net income). If any portion
of the Project is occupied by a tax exempt tenant so that the Project has a partial tax exemption under ORS 307.112 or a similar statute, the real property taxes and assessments shall mean real property taxes and assessments computed as if such
partial exemption did not exist. 
 (3) Tenant’s Share. Tenant’s share of the operating expenses, taxes and
assessments of the Project shall be a percentage thereof equal to the percentage which the rentable square feet of the Premises bears to the total rentable square feet of the Project. Tenant’s share shall be based on the total rentable area of
the Project whether such area is occupied or not and shall not be adjusted to reflect vacancy in the Project, Notwithstanding the foregoing, Landlord shall be permitted to adjust Tenant’s percentage share of any item of operating expense to
allocate such operating expense among tenants in the Project in an equitable manner based upon the usage of and benefits afforded to such tenants, respectively. Landlord shall also be permitted to adjust Tenant’s share of any portion of any
real property taxes and assessments in the event a tenant within the Shopping Center is billed directly or separately assessed for such portion of real property taxes and assessments by the taxing authority. In such

  
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event, Landlord shall be permitted to exclude such tenant’s area from the total net rentable area of the Shopping Center for the purposes of determining Tenant’s share of such portion
of real property taxes and assessments. 
 (4) Payment. Upon commencement of the Lease term and at the beginning of each
calendar year during the term of the Lease, Landlord may reasonably estimate Tenant’s share of operating expenses and taxes and assessments for the ensuing calendar year or portion thereof, Landlord may revise the estimate during the course of
any year. Tenant will pay one-twelfth of Tenant’s estimated share of operating expenses and taxes and assessments on the first day of each calendar month during the term hereof. If Landlord bills on an estimated basis, Landlord shall, within
120-days (or as soon thereafter as possible) after the end of any calendar year give Tenant written notice of Tenant’s actual share of operating expenses and taxes and assessments. If Tenant’s payments of its estimated share for such
calendar year differ from Tenant’s actual share, an appropriate adjustment shall be made within 30-days after the giving of such notice. Any objections by Tenant to the annual statement shall be made in writing within thirty days after receipt
thereof. Otherwise, the annual statement shall be deemed conclusive and binding on the parties. If Landlord bills on an actual basis Tenant will pay Tenant’s actual share of operating expenses and taxes and assessments on the first day of the
first calendar month after such bill. 
 (5) Parking Facility Agreement. This Lease is subject to the Parking Agreement.

 (6) Reciprocal Easement. Landlord reserves the right to subject the Project to reciprocal easements, covenants and
restrictions to which this Lease shall automatically be subordinate. In such event, the operating expenses for the Project shall be deemed to include, without limitation, Landlord’s share of such costs under the reciprocal easements, covenants
and restrictions. 
 3.3 Interest and Late Charges. All rent and other payments not paid within thirty (30) days
when due shall bear interest from the due date until fully paid at the rate of twelve percent (12%) per annum, but not in any event at a rate greater than the maximum rate of interest permitted by law. In addition, Tenant acknowledges that late
payment of any rent or other payment required by this Lease from Tenant to Landlord will result in collection costs to Landlord, the extent of which additional costs is extremely difficult and economically impractical to ascertain. Tenant therefore
agrees that if Tenant fails to make any rent or other payment required by this Lease to be paid to Landlord within ten (10) days when it is due, Landlord may elect to impose a late charge of five cents (50) per dollar of the overdue
payment, to reimburse Landlord for the costs of collecting the overdue payment. Tenant shall pay the late charge upon demand by Landlord. Tenant agrees that the late charge is a reasonable estimate of the costs to Landlord of collecting the overdue
payment. Landlord may levy and collect a late charge in addition to all other remedies available for Tenant’s default, and collection of a late charge shall not waive the breach caused by the late payment. 

3.4 Net Lease Provision. All payments required to be paid by Tenant under this Lease, other than minimum rent, will constitute
additional rent. This is intended to be a net lease, meaning that Tenant shall pay all expenses of every type relating to the Premises after commencement of the lease term, all rent (including minimum and additional rent) shall be received by
Landlord without setoff, offset, abatement, or deduction of any kind. 

  
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 Section 4 BUSINESS PURPOSE. 

4.1 Permitted Use. Tenant shall use the Premises only for the purpose of a general office use which may include biotechnological,
pharmaceutical and medical office use and for no other purpose without the Landlord’s express written consent. 
 4.2
Compliance with Laws. In connection with its use, Tenant shall comply at its expense with all applicable laws, regulations and requirements of any public authority, including those regarding maintenance, operation and use of the Premises and
any appliances on the Premises (including signs), 
 4.3 Insurance. Tenant shall not conduct or permit any activities on
the Premises which will: increase the fire insurance rate upon the Project or cause a cancellation of the fire insurance policy; or create a nuisance or damage the reputation of the Project or be reasonably offensive to Landlord or other tenants

 4.4 Supervision. Tenant shall keep the Premises clean and orderly and will cause its employees on the Premises to be
well groomed and dressed in accordance with a first-class, professional operation of Tenant’s business. Tenant will supervise its employees and cause Tenant’s agents, independent contractors, employees, customers, suppliers and invitees to
conduct their activities in such a manner as to comply with the requirements of this Lease and the rules and regulations described herein. 
 4.5 Common Areas. All common areas within the Project shall be used in strict compliance with Landlord’s reasonable rules, regulations and requirements for such areas. 

4.6 Name of Business. The advertised name of the business operated in the Premises shall be RXi Pharmaceuticals or any other such
name the originally-named Tenant is legally identified as. 
 4.7 Parking. Tenant shall comply with the Garage rules,
regulations and requirements as adopted and published by Landlord from time to time and shall cause Tenant’s customers, employees and invitees to abide by such rules, regulations and requirements. Landlord reserves the right to restrict the use
of designated stalls or areas within the Garage. When requested by Landlord, Tenant shall give Landlord written notice of the license number of all vehicles parked in the Project by Tenant’s officers, employees, agents and contractors. If a
vehicle of Tenant’s or its officers, employees, agents or contractors is at any time parked in a part of the Project or Garage other than the designated area, Landlord shall have the right to have the vehicle towed and to collect towing and
storage charges as a condition of releasing the vehicle to its owner or to charge the owner of the vehicle a per diem fee for each vehicle so parked. 
 During the hours of 7:00 am — 5:00 pm Monday through Friday (“Office Hours”), Tenant shall have the exclusive right to use four (4) parking stalls for employee parking. 

  
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 4.8 Storage, Trash. Tenant shall not store anything outside except in areas approved
by Landlord. Tenant will use only trash and garbage receptacles approved by Landlord. Tenant shall dispose of trash and other matter in a manner acceptable to Landlord, at Tenant’s expense. 

Section 5 UTILITIES AND SERVICES. 
 5.1 Building Maintenance. Landlord shall maintain the public and common areas of the Project and the Building structure in good condition and repairs. 

5.2 Utility Service. Landlord shall supply the Premises with electricity for lighting and operation of normal office equipment,
heating ventilation and cooling to a standard of comfort customary in other comparable office buildings in the area, janitorial services and such other services as Landlord may elect during the times and in the manner that such services are
customarily furnished in comparable office buildings in the area. Landlord shall not be in default hereunder or be liable for any failure or interruption of utilities or services to the Premises. Landlord shall take reasonable steps to restore
service as soon as practical subject to causes beyond Landlord’s reasonable control. Gas, electricity, water and sewer used in the office portion of the Project shall be separately metered from gas, electricity, water and sewer used in the
retail portion of the Project. Tenant shall pay its proportionate share of all Project utilities including but not limited to parking area lighting, elevator electricity and landscape irrigation pursuant to Section 3.2 hereof. Landlord shall
reasonably allocate operating expenses of the Project based on projected and actual costs associated with each. All such costs and services incurred shall be an Operating Expense pursuant to Section 3.2 hereof. 

Section 6 INSURANCE; INDEMNITY. 
 6.1 Public Liability Insurance. Tenant shall continuously maintain at its expense comprehensive general liability insurance, with limits of not less than $2,000,000 per person, $2,000,000 per
occurrence for injury to, illness of, or death of persons occurring in, upon or about the Premises or Project, and $200,000 per occurrence for property damage occurring in, upon or about the Project with fire legal liability endorsement with limits
no less than $200,000. All such insurance shall insure the performance by Tenant of the indemnity agreement set forth in Section 6.5 hereof. 
 6.2 Fire Insurance of Tenant. Tenant, at its expense, shall maintain in effect; fire and extended coverage insurance on furnishings, leasehold improvements, fixtures, inventory and equipment
located on the Premises, for the full replacement value. The proceeds of such insurance, so long as this Lease remains in effect, shall be used to repair or replace the leasehold improvements, fixtures, equipment and plate glass so insured.

 6.3 Insurance Policies. All insurance policies shall name Landlord, its managers and members and any managing agent
and other designee as additional insureds and shall be with companies and with loss-payable clauses satisfactory to Landlord and with ratings no less than A+ by A.M. Best. Copies of all policies or certificates evidencing such insurance shall be
delivered to Landlord by Tenant prior to Tenant’s occupancy of the Premises. All policies shall be primary and noncontributing with any insurance which may be carried by Landlord. All policies shall bear endorsements requiring 30 days written
notice to Landlord prior to any change or cancellation. 

  
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 6.4 Waiver of Subrogation. Neither party shall be liable to the other for any loss or
damage caused by water damage or any of the risks covered by a standard fire insurance policy with extended coverage endorsements, and there shall be no subrogated claim by one party’s insurance carrier against the other party arising out of
any such loss. 
 6.5 Indemnity of Landlord. Tenant hereby waives all claims against Landlord for damage to any property
or injury, illness or death of any person in, upon, or about the Premises and/or Shopping Center arising at any time and from any cause whatsoever. Tenant shall defend, indemnify and hold harmless Landlord, its managers and members and any managing
agent or other designee from any and all claims or liability for any damage to any property or injury, illness, or death of any person occurring in or on the Premises or occurring elsewhere in the Shopping Center when such damage, injury, illness,
or death shall be caused in whole or in part by the act or failure to act of Tenant, its agents, servants, employees, invitees, contractors, or licensees. 
 Section 7 REPAIRS, MAINTENANCE AND ALTERATIONS. 
 7.1
Condition of Premises. By entry hereunder Tenant accepts the Premises as being in the condition in which Landlord is obligated to deliver the Premises. Tenant shall, at Tenant’s own expense, keep the Premises in good condition and
repair, including without limitation, the maintenance, replacement and repair of any walls, floors, ceilings, interior doors, interior windows and fixtures, interior plumbing (if any), electrical wiring and conduits. Tenant shall be responsible for
all repairs, interior and exterior, structural and non-structural, ordinary and extraordinary, in and to the Premises and the Project and the facilities and systems thereof, the need for which arises out of the performance or existence of the
Tenant’s alterations, the installation, use or operation of Tenant’s property in the Premises, the moving of Tenant’s property in or out of the Project, or the act, omission, misuse or neglect of Tenant, its agents, employees,
contractors or invitees. Tenant shall promptly make, at Tenant’s expense, all repairs in or to the Premises for which Tenant is responsible. Such work shall be performed only by contractor(s) designated or approved in writing by the Landlord.
Tenant shall, upon the termination of this Lease, surrender the Premises to Landlord, in good condition except for ordinary wear and tear and for damage covered by Landlord’s fire and extended coverage insurance. 

7.2 Climate Control. Landlord shall maintain and operate the heating, ventilating and air-conditioning systems serving the
Premises for occupancy of the Premises during Business Hours of Business Days, the expense of which shall be included in Operating Expense of the Project as defined in Section 3.2 hereof. As used herein, “Business Hours” shall mean
generally customary daytime business hours, but not before 7:30 a.m. or after 6 p.m. on weekdays and not before 7:30 a.m. or after 1 p.m. on Saturdays. “Business Days” shall mean all days except Sundays and days observed by the Federal or
State government as legal holidays. Tenant shall have the right to use and control the HVAC system within the Premises during hours outside Business Hours. 

  
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 7.3 Alterations. Tenant shall not make any alterations or improvements to the
Premises without the prior written consent of Landlord. Any alterations or improvements to the Premises (excluding trade fixtures installed by Tenant), shall become part of the Premises and belong to Landlord and shall be surrendered with the
Premises without disturbance upon the termination of the Lease. In the event Landlord consents to the making of any alterations or improvement, the same shall be made at Tenant’s sole expense. 

7.4 Trade Fixtures. Upon expiration or earlier termination of the Lease, Tenant shall remove all trade fixtures, movable furniture
and equipment located on the Premises which belong to the Tenant, and repair at its expense any damage caused to the Premises by such removal. If Tenant fails to remove such property, this shall be an abandonment of the property and Landlord may
retain the property and all rights of Tenant with respect to it shall cease or, by notice in writing given to Tenant within 20 days after removal was required, Landlord may elect to hold Tenant to its obligation of removal. If Landlord elects to
require Tenant to remove, Landlord may effect a removal and place the property in storage for Tenant’s account. Tenant shall be liable to Landlord for the cost or reasonable value of removal, restoration, transportation to storage and storage,
with interest on all such as expenses as provided in paragraph 13.3 below. 
 7.5 Compliance With The Laws. Tenant should
not use the Premises or permit anything to be done in or about the Premises which will conflict with any law or regulation. 

7.6 Entry and Inspection. With reasonable notice except in an emergency, Landlord or its agents may enter the Premises at any time
to determine Tenant’s compliance with this Lease, to make necessary repairs, or to show the Premises to prospective tenants or purchasers. 

Section 8 RECONSTRUCTION AND RESTORATION. 
 8.1 Minor Damage. If during the term hereof the Premises are destroyed or damaged by fire or other perils covered by Landlord’s fire and extended coverage insurance and such damage is not
“substantial,” Landlord shall promptly repair such damage to Landlord’s Work in the Premises and this Lease shall continue in full force and effect. 
 8.2 Substantial Damage. If during the term hereof the Premises are destroyed or damaged by fire or other perils covered by Landlord’s insurance in an amount exceeding twenty-five percent
(25%) of its full construction-replacement cost or other peril not covered by Landlord’s insurance, then Landlord may elect to terminate this Lease by giving Tenant written notice of such termination within 60 days after the date of such
damage. Otherwise, Landlord shall proceed to restore Landlord’s Work in the Premises to a condition comparable to that existing prior to the damage. Tenant shall cooperate with Landlord during the period of repair and vacate all or any part of
the Premises to the extent necessary for the performance of the required work. Landlord need not incur expenses for restoration in excess of the net insurance proceeds available to Landlord after payment of all reasonable costs, expenses and
attorneys’ fees incurred by Landlord in connection therewith. 
 8.3 Abatement of Rent. The minimum rent shall be
abated during the period and to the extent the Premises is not reasonably usable for Tenant’s use. if the damage does not cause any material interference with Tenant’s use, there shall be no rent abatement. 

  
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 8.4 Repair of Tenant’s Property. Repair, replacement, or restoration of any
fixtures, equipment and personal property owned by Tenant, and Tenant improvements shall be the responsibility of Tenant. 
 Section 9
ASSIGNMENT AND SUBLETTING. Tenant shall not (voluntarily or by operation of law) assign, mortgage, pledge, hypothecate or encumber the Premises or Tenant’s leasehold estate or sublet any portion of the Premises, or otherwise
transfer any interest in the Premises without Landlord’s prior written consent in each instance which consent shall not be unreasonably withheld or delayed. In determining whether to consent, Landlord may consider any reasonable factor
including without limitation, credit worthiness, business experience, general reputation and ability to perform the terms of this Lease of the proposed transferee. If Tenant is a corporation, transfer of a fifty percent (50%) or greater
interest in cumulative total in any 2-year period in the stock of Tenant shall be deemed an assignment within the meaning of this Section. If Tenant is a partnership, any change in the partners shall be deemed an assignment of this Lease. if Tenant
requests consent to a proposed transfer, Tenant shall pay a review fee of $200 at the time of the request for application to Landlord’s expenses in reviewing the request for consent to transfer. 

Section 10 CONDEMNATION. 
 10.1 Entire or Substantial Taking. If more than twenty-five percent (25%) of the Premises (notwithstanding restoration by Landlord as herein provided) shall be taken under the power of eminent
domain, this Lease shall automatically terminate on the date the condemning authority takes possession. 
 10.2 Partial
Taking. In the event of any taking under the power of eminent domain which does not so result in a termination of this Lease, the minimum rent payable hereunder shall be reduced, effective on the date the condemning authority takes possession,
in the same proportion as the reduction in rentable floor area of the Premises. Landlord shall promptly, at its sole expense, restore the portion of the Premises not taken to as near its former condition as is reasonably possible, and this Lease
shall continue in full force and effect. 
 10.3 Awards. Any award for taking of all or any part of the Premises under
the power or eminent domain shall be the property of the Landlord, whether such award shall be made as compensation for diminution in value of the leasehold or for taking of the fee. Nothing herein, however, shall be deemed to preclude Tenant from
obtaining, or to give Landlord any interest in, any award to Tenant for loss of or damage to or cost of removal of Tenant’s trade fixtures and removable personal property, or for damages for cessation or interruption of Tenant’s business.

 10.4 Sale Under Threat of Condemnation. A sale by Landlord to any authority with power of eminent domain, either under
threat of condemnation or while condemnation proceedings are pending, shall be deemed a taking under the power of eminent domain under this Section. Landlord need not incur expenses for restoration in excess of the amount of condemnation proceeds
received by Landlord after payment of all reasonable costs, expenses and attorneys’ fees paid or incurred by Landlord in connection with the condemnation. 

  
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 Section 11 SIGNS. Tenant shall not inscribe, post, place or in any manner display any
sign notice, picture, placard, or any advertising matter, anywhere in, on or about the Premises or the Project without first obtaining Landlord’s prior written consent. Tenant shall be permitted to place identification signage to the right of
the interior door to the Premises. Landlord shall produce and install said door signage in accordance with building standards and at Tenant’s expense. Any sign on the Premises will be designed and constructed in compliance with applicable sign
codes. Tenant shall be responsible for the removal of its sign(s) and the repair of any damage to the building as a result of the sign’s presence or removal. 
 Section 12 OTHER OBLIGATIONS OF PARTIES. 
 12.1 Liens.
Tenant shall pay as due all claims for work done on the Premises or for services rendered or materials furnished to the Premises and shall keep the Premises free from any liens other than liens created by Landlord. If Tenant fails to pay such claim
or to discharge any lien, Landlord may do so and collect such amount as additional rent. Amounts paid by Landlord shall bear interest and be repaid by Tenant as provided in paragraph 13.3 below. Such payment by Landlord shall not constitute a waiver
of any right or remedy Landlord may have because of Tenant’s default. 
 12.2 Holding Over. If Tenant does not
vacate the Premises at the time required, Landlord shall have the option to treat Tenant as a tenant from month to month, subject to all of the provisions of this Lease (except that the term will be month to month and the initial minimum monthly
rent will be one hundred fifty percent {150%) of the minimum monthly rent then being paid by Tenant), or to eject Tenant from the Premises and recover damages caused by wrongful hold over. 

12.3 Non merger. The voluntary or other surrender of this Lease by Tenant, or a mutual cancellation thereof, shall not work a
merger, and shall, at the option of the Landlord, terminate all and any existing subtenancies, or may, at the option of Landlord, operate as an assignment to it of any and all such subtenancies. 

12.4 Rights of Landlord. Landlord shall have the right to change the name or designation of the Project without notice or
liability to Tenant. Landlord shall also have the right to grant to anyone the exclusive right to conduct a particular business or undertaking in the Project. Landlord has entered into a Declaration of Restrictive Covenants with the Lake Oswego
Redevelopment Agency (the “Restrictive Covenants”) to which this lease is subordinate. Tenant shall not use the Premises for any use which violates such Restrictive Covenants. 

12.5 Priority of Lease. This Lease shall be subject and subordinated at all times to the lien of all mortgages and deeds of trust
subsequently placed upon the Project all without the necessity of having further instruments executed on the part of Tenant to effectuate such subordination. If any party providing financing or funding to Landlord requires, as a condition to such
financing or funding, that Tenant send such party written notice of any default by Landlord under this Lease, giving such party the right to cure such default until it has completed foreclosure and preventing Tenant from terminating this Lease
unless such default remains uncured after foreclosure has been completed, Tenant will execute and deliver any agreement required by such party in order to accomplish this purpose. 

  
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 12.6 Landlord’s Liability; Sale. The liability of Landlord under this Lease will
be limited to Landlord’s interest in the Project, and any judgment against Landlord will be enforceable solely against Landlord’s interest in the Project. In the event the original Landlord hereunder, or any successor owner of the Project,
shall sell or convey the Project, all liabilities and obligations on the part of the original Landlord, or such successor owner, under this Lease accruing thereafter shall terminate, and thereupon all such liabilities and obligations shall be
binding upon the new owner. Tenant agrees to attorn to such new owner. 
 12.7 Estoppel Certificate. Within 10 days after
Landlord’s written request, Tenant shall deliver a written statement stating the date to which the rent and other charges have been paid, whether the Lease is unmodified and in full force and effect, and any other matters that may reasonably be
requested by Landlord. 
 12.8 Rules and Regulations. Tenant agrees to comply with any rules and regulations for the
Project adopted and published by Landlord from time to time and to cause Tenant’s customers, employees and invitees to abide by such rules and regulations. Tenant agrees that Landlord shall not be responsible to Tenant for the noncompliance by
any other tenant or occupancy of the Project with such rules and regulations. 
 12.9 Financial Statements. Upon written
notice from Landlord, Tenant agrees to provide current financial statements for the Tenant and/or Guarantor. Landlord hereby agrees to maintain the confidentiality of all such statements; however Landlord may disclose such to its attorneys,
accountants or other professional advisors and any current or potential mortgagee or purchaser of the Property, and in connection with any proceeding to enforce the terms of this Lease. 
 Section 13 DEFAULTS; REMEDIES. 
 13.1 Default. The
following shall be events of default: 
 (1) Payment Default. Failure of Tenant to make any base, percentage or
additional rent or other payment under this Lease for a period of ten (10) days after it becomes due and payable. 
 (2)
Unauthorized Transfer. Any transfer by Tenant without Landlord’s prior written consent as required under Section 9. 
 (3) Abandonment of Premises. Tenant fails to occupy or use the Premises for the purposes permitted by this Lease for a total of ten (10) consecutive business days or more during the lease
term, unless such failure is excused under other provisions of this Lease. 
 (4) Default In Other Covenant. Failure of
Tenant to comply with any other term or condition or fulfill any other obligation of this Lease within 20-days after written notice by Landlord specifying the nature of the default with reasonable particularity. No notice and no opportunity to cure
shall be required if Landlord has previously given Tenant notice of failure to comply with such term or condition or fulfill such other obligation of this Lease during the term hereof. 

  
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 (5) Insolvency Defaults. Dissolution, termination of existence, insolvency on a
balance sheet basis or business failure of Tenant; the commencement by Tenant of a voluntary case under the federal bankruptcy laws or under any other federal or state law relating to insolvency or debtor’s relief; the entry of a decree or
order for relief against Tenant in an involuntary case under the federal bankruptcy laws or under any other applicable federal or state law relating to insolvency or debtor’s relief; the appointment of or the consent by Tenant to the
appointment of a receiver, trustee or custodian of Tenant or of any of Tenant’s property; an assignment for the benefit of creditors by Tenant; Tenant’s failure generally to pay its debts as such debts become due; the making or suffering
by Tenant of a fraudulent transfer under applicable federal or state law; concealment by Tenant of any of its property in fraud of creditors; the making or suffering by Tenant of a preference within the meaning of federal bankruptcy law; or the
imposition of a lien through legal proceedings or distraint upon any of the property of Tenant which is not discharged or bonded. During any period in which there is a Guarantor(s) of this Lease, each reference to “Tenants” in this
paragraph shall be deemed to refer to “Guarantor or Tenant,” separately. 
 13.2 Remedies on Default. Upon
default, Landlord may exercise any one or more of the following remedies, or any other remedy available under applicable law: 

(1) Retake Possession. With or without terminating the Lease, to the extent permitted by law, Landlord may re-enter and retake
possession of the Premises and terminate Tenant’s tenancy, without notice, either by summary proceedings, force, any other applicable action or proceeding, or otherwise. Landlord may use the Premises for Landlord’s own purposes or relet it
upon any reasonable terms without prejudice to any other remedies that Landlord may have by reason of Tenant’s default. None of these actions will be deemed an acceptance of surrender by Tenant. To the extent permitted by law, Tenant expressly
waives the service of any notice of intention to terminate Tenant’s tenancy or Tenant’s right to possession or to retake the Premises, and waives service of any demand for payment of rent or for possession, and of any and every other
notice or demand required or permitted under applicable law. 
 (2) Relet the Premises. Landlord at its option may relet
the whole or any part of the Premises, from time to time, either in the name of Landlord or otherwise, to such tenants, for such terms ending before, on, or after the expiration date of the lease term, at such reasonable rentals and upon such other
reasonable conditions (including concessions and free rent periods) as Landlord, in its sole discretion, may reasonably determine to be appropriate. Landlord shall have no obligation to relet the Premises or any part and shall not be liable for
refusal or failure to relet the Premises, or in the event of any such reletting, for refusal or failure to collect any rent due upon such reletting. No such refusal or failure shall operate to relieve Tenant of any liability under this Lease or
otherwise affecting such liability. Landlord at its option may make such physical changes to the Premises as Landlord, in its sole discretion, considers advisable or necessary in connection with any such reletting or proposed reletting without
relieving Tenant of any liability under this Lease or otherwise affecting Tenant’s liability. If there is other comparable unleased space in the Project, Landlord shall have no obligation to attempt to relet the Premises prior to leasing other
space in the Project. 
 (3) Damages for Default. Whether or not Landlord retakes possession or relets the Premises,
Landlord may recover all damages caused by the default (including but not 

  
 11 

 
limited to unpaid rent, attorneys’ fees relating to the default, and costs of reletting). Landlord may sue periodically to recover damages as they accrue during the remainder of the lease
term without barring a later action for further damages. Landlord may at any time bring an action for accrued damages plus damages for the remaining lease term equal to the difference between the rent specified in this Lease and the reasonable
rental value of the Premises for the remainder of the term, discounted to the time of judgment at the rate of six percent (6%) per annum. 
 (4) Continuation after Default. Even though Tenant is in default under this Lease, this Lease shall continue in effect so long as Landlord does not terminate this Lease, and Landlord may enforce
all its rights and remedies under this Lease, including the right to recover the rent as it becomes due under the Lease. Upon default, Landlord may terminate this Lease by giving written notice of termination of this Lease to Tenant. Termination of
Tenant’s tenancy or Tenant’s right to possession, acts of maintenance or preservation or efforts to relet the Premises or the appointment of a receiver upon initiative of Landlord to protect Landlord’s interest under this Lease shall
not constitute a termination of this Lease unless written notice of termination of this Lease is given by Landlord to Tenant. 

13.3 Cure of Tenant’s Default. Without prejudice to any other remedy for default, Landlord may perform any obligation or make
any payment required to cure a default by Tenant. The cost of performance, including attorneys’ fees and all disbursements, shall immediately be repaid by Tenant upon demand, together with interest from the date of expenditure until fully paid
at the rate of fourteen percent (14%) per annum, but not in any event at a rate greater than the maximum rate of interest permitted by law. 
 13.4 Cumulative Remedies. The remedies provided for in this Lease are cumulative and not intended to be exclusive of any other remedy to which Landlord may lawfully be entitled at any time, and
Landlord may invoke any such remedy, including, without limitation, termination of the tenancy under ORS 91.090, as if specific remedies were not provided for herein. 
 Section 14 SECURITY DEPOSITS. Tenant shall upon execution hereof deposit with the Landlord the sum of Three Thousand Two Hundred Four and no/100 Dollars ($3,204.00), as security for the
full and faithful performance by Tenant of every provision of this Lease. If Tenant violates any provision of this Lease, Landlord may, but shall not be obligated to, apply all or any part of this security deposit to remedy such violation. If any
portion of said deposit is so applied, Tenant shall immediately deposit with Landlord cash in an amount sufficient to restore the security deposit to its original amount. Landlord may commingle this deposit with Landlord’s funds and Tenant
shall not be entitled to interest on such deposit. If Tenant shall fully and faithfully perform every provision of this Lease, the security deposit or any balance thereof shall be returned to Tenant within 10 days after the expiration of the lease
term. 
 Section 15 LANDLORD’S AND TENANT’S WORK. 

15.1 By Landlord. Landlord shall perform the work described as Landlord’s Work in attached Exhibit B. 

  
 12 

 15.2 By Tenant. Tenant shall perform all other work required to ready the Premises
for Tenant’s use and occupancy in accordance with attached Exhibit B. 
 Section 16 MISCELLANEOUS. 

16.1 Waivers. No waiver by Landlord of performance of any provision of this Lease shall be deemed to be a waiver of nor prejudice
Landlord’s right to otherwise require performance of the same provision or any other provision. 
 16.2 Recording.
Tenant shall not record this Lease. 
 16.3 Notices. All notices under this Lease shall be in writing effective when
delivered in person, or if mailed, upon deposit in the United States Mail, certified and postage prepaid and addressed to the address of Tenant or Landlord shown below or at such other address as may be designated by either party by notice to the
other. 
 16.4 Exhibits and Riders. Exhibits and riders, if any, initialed or signed by Landlord and Tenant, and attached
or affixed to this Lease, are a part hereof as if set forth in full herein. 
 16.5 Construction. (a) This Lease
shall be construed and governed by the laws of the State of Oregon; (b) the invalidity or unenforceability of any provision hereof shall not affect or impair any other provisions hereof; (c) this Lease constitutes the entire agreement of
the parties and supersedes all prior agreements or understandings between the parties with respect to the subject matter hereof; (d) this Lease may not be modified or amended except by written agreement signed and acknowledged by both parties;
(e) if there be more than one tenant, the obligations hereunder imposed upon Tenant shall be joint and several; (f) time is of the essence of this Lease in each and every provision hereof; and (g) nothing contained herein shall create
the relationship of principal and agent or of partnership or of joint venture between the parties hereto and no provisions contained herein shall be deemed to create any relationship other than that of landlord and tenant. 

16.6 Successor. Subject to any limitations on assignments herein, all of the provisions of this Lease shall inure to the benefit
of and be binding upon the successors and assigns of the parties hereto. 
 16.7 Attorneys’ Fees. In the event suit
or action is instituted to interpret or enforce the terms of this Lease, the prevailing party shall be entitled to recover from the other party such sum as the court may adjudge reasonable as attorneys’ fees at trial, on petition for review, or
on appeal, in addition to all other sums provided by law. 
 16.8 Hazardous Substances. Tenant shall not use, generate
transport, treat, store, dispose of or otherwise handle Hazardous Substances on the Leased Premises without the prior written consent of Landlord, except Hazardous Substances and in quantities commonly used in business offices, provided such
Hazardous Substances are maintained and used in accordance with applicable laws relating thereto, Landlord may withhold such consent in its sole discretion or may condition such consent upon Tenant’s agreement to comply with requirements
designated by Landlord. The term “Hazardous Substances” shall mean any and all hazardous, toxic, infectious or radioactive substances, wastes or materials as defined or listed by any federal, state or local statute, regulation or ordinance
pertaining to the protection of human health or the environment and shall specifically include petroleum oil and its fractions. 

  
 13 

 16.9 No Offer. This Lease is submitted to Tenant on the understanding that it will
not be considered an offer and will not bind Landlord in any way until (a) Tenant has duly executed and delivered duplicated originals to Landlord and (b) Landlord has executed and delivered one of such originals to Tenant. 

16.10 Consent. Unless Landlord’s consent or approval is required by the express terms of this Lease not to be unreasonably
withheld, such approval or consent may be withheld, delayed or conditioned by Landlord in its sole and arbitrary discretion. 
  

							
	LANDLORD:	 	TENANT:
		
	LO 138 LLC,	 	RXi PHARMACEUTICALS CORPORATION
	an Oregon limited liability company	 	a Delaware corporation
				
	By:	 	Gramor 138 LLC,	 		 	
		 	an Oregon limited liability company	 		 	
		 	Manager	 		 	
				
	By:	 	Gramor Investments, Inc.,	 		 	
		 	an Oregon Corporation	 		 	
		 	Manager	 		 	
				
	By:	 	 /s/ Barry A. Cain
	 	By:	 	 /s/ Mark J. Ahn

		 	Barry A. Cain, President	 		 	Mark J. Ahn, President/CEO
				
	Date:	 	 7/18/11
	 	Date:	 	 7/18/11

		
	Landlord Address:	 	Tenant Address:
	19767 SW 72nd Avenue, Suite 100	 	60 Prescott Street
	Tualatin, OR 97062	 	Worcester, MA 01605
	(503) 245-1976	 	(503) 961-4465

  

			
	and a copy to:	 	Thomas R. Page
		 	Stoel Rives
		 	900 S.W. Fifth Avenue Suite 2600
		 	Portland, OR 97204

  
 14 

					
	STATE OF OREGON            	 	)	 	
		 	)	 	ss
	County of Washington	 	)	 	

 On this day personally appeared before me MARK J. AHN, to me known to be the PRESIDENT/CEO, of the
corporation described as Tenant in the foregoing instrument, and acknowledged the said instrument to be the free and voluntary act and deed of said corporation for the uses and purposes therein mentioned, and on oath stated that they were authorized
to execute the said instrument on behalf of the corporation. 
 GIVEN under my hand and official seal this 18th day of July,
2011. 
  

			
	Official Seal	 	 /s/ Kristin Jennifer Woods

	 Kristin Jennifer Woods
 Notary
Public – Oregon
 Commission No. 447699
 My Commission Expires May 19, 2014
	 	Notary Public in and for the State of Oregon

  

					
	STATE OF OREGON            	 	)	 	
		 	)	 	ss
	County of Washington	 	)	 	

 On this day personally appeared before me BARRY A. CAIN, to me known to be the President of Gramor
Investments, Inc., that executed the foregoing instrument, and acknowledged the said instrument to be the free and voluntary act and deed of said corporation for the uses and purposes therein mentioned, and on oath stated that he was authorized to
execute the said instrument on behalf of the corporation and Landlord. 
 GIVEN under my hand and official seal this 18th day of
July, 2011. 
  

			
	Official Seal	 	 /s/ Kristin Jennifer Woods

	 Kristin Jennifer Woods
 Notary
Public – Oregon
 Commission No. 447699
 My Commission Expires May 19, 2014
	 	Notary Public in and for the State of Oregon

 LIST OF EXHIBITS AND RIDERS 

ATTACHED HERETO AND MADE A PART HEREOF 
 “LAKE VIEW VILLAGE” 
  

			
		
	EXHIBIT “A-1”	  	Premises
		
	EXHIBIT “A-2”	  	Site Plan
		
	EXHIBIT “A-3”	  	Legal Description of the Project
		
	EXHIBIT “B”	  	Construction Exhibit
		
	EXHIBIT “C”	  	Shopping Center Rules and Regulations
		
	RIDER:	  	Option to Extend

 EXHIBIT “A-2” 

SITE PLAN 

LAKE VIEW VILLAGE 
  

 

 EXHIBIT “A-2” 

SITE PLAN 

LAKE VIEW VILLAGE 
  

 

 EXHIBIT “A-3” 

LEGAL DESCRIPTION OF THE PROJECT 
 “LAKE VIEW VILLAGE” 
 Parcel 2 of PARTITION PLAT NO 2002-076, a duly filed plat,
in the City of Lake Oswego, County of Clackamas, State of Oregon. 

 EXHIBIT “B” 

DESCRIPTION OF LANDLORD’S WORK AND TENANT’S WORK 
 “LAKE VIEW VILLAGE” 
 RXi PHARMACEUTICALS 

Page 1 of 1 

CONSTRUCTION OF TENANT’S PREMISES: 

Landlord agrees that it will, at its sole cost and expense, commence and pursue to completion the construction of the improvements as stated in
“Description of Landlord’s Work” herein. 
 DESCRIPTION OF LANDLORD’S WORK: 

Landlord shall paint the interior of the Premises in a color(s) mutually agreeable to Tenant and Landlord. Other than outlined herein, Landlord shall
deliver the Premises to Tenant in “as is” condition. 
 DESCRIPTION OF TENANT’S WORK: 

Except as provided under “Description of Landlord’s Work”, all work in the Premises shall be provided by or for Tenant at Tenant’s
expense. This work shall include, but not be limited to the following: 
  

	1.	In the event Tenant plans to make alternations to the Premises which require a building permit, Tenant shall within twenty (20) days after receipt of
Landlord’s floor plan, submit to Landlord two (2) prints and one (1) reproducible set of full dimensioned 1/8 inch scale or larger drawings on 24” x 36” sheets plus specifications prepared by Tenant’s architect or
designed at Tenant’s expense if Landlord’s architect is used, which drawings shall indicate the specific requirement of Tenant’s space showing clearly the storefront, interior partitions, colors, materials, trade fixtures plans,
lighting and electrical outlets all in conformity with the provision of this Exhibit “B” and which shall be suitable for submittal for issuance of required permits. 

 

	2.	Any special or decorative lighting including any additional service panel capacity that may be required as a result. 

 

	3.	Special furred, covered or dropped ceiling areas. 

  

	4.	All interior painting, floor covering and other finishes not included in Landlord’s work. 

 

	5.	Al partitions and doors not included under Landlord’s work. 

  

	6.	If the Landlord performs any of Tenant’s work, then the cost of said work shall be paid in the following manner: Fifty percent (50%) prior to commencement of
construction and the balance immediately following completion. Payment is due upon receipt of invoice. The entire payment of the invoice must be received by landlord prior to Tenant occupying the Premises and issuance of keys.

	7.	If Tenant penetrates roof membrane, Tenant shall, at its expense, use Landlord’s roofing contractor to repair all such penetrations. Al repairs shall comply with
the requirements under the roof warranty. 

  

	8.	Tenant’s licensed general contractor must be approved by Landlord prior to Tenant issuing a contract. 

  
 2 

 EXHIBIT “C” 

TO OFFICE LEASE AGREEMENT 
 RULES AND REGULATIONS 
 “LAKE VIEW VILLAGE” 

Page 1 of 4 
  

	1.	The entrance, halls, corridors, stairways and elevator shall not be obstructed by any of the tenants or used for any purpose other than for ingress and egress from
their respective premises. The entrances, halls, corridors, stairways, walkways, and the elevator are not intended for use by the general public but for the tenant and its employees, licensees and invitees. Landlord reserves the right to control and
operate the public portions of the building in which the Premises are located (the “Building”), the Project, and the public facilities as well as facilities furnished for the common use of the tenants, in such manner as it in its
reasonable judgment deems best for the benefit of the tenants generally. No tenant shall invite to the tenant’s premises, or permit the visit of persons in such numbers or under such conditions as to interfere with the use and enjoyment of any
of the entrances, corridors, elevator and other facilities of the Building or Project by any other tenants. 

  

	2.	No awnings or other projections shall be attached to the outside walls of the Building. No curtains, blinds, shades or screens, if any, which are different from the
standards adopted by Landlord for the Project shall be attached to or hung in any exterior window or door or the premises of any tenant without the prior written consent of Landlord, which consent shall not be unreasonably withheld.

  

	3.	Tenant may mark, drive nails or screw or drill on or into the partitions, woodwork or plaster of the Premises; provided, however, that any damage caused thereby shall
be repaired by Tenant, at Tenant’s expense, prior to the expiration of the lease term. Tenant shall not penetrate the ceiling or floor of the Premises without the prior written consent of Landlord. 

 

	4.	No sign, placard, picture, name lettering, advertisement, notice or object visible from the exterior of any tenant’s premises shall be displayed in or on the
exterior windows or doors, or on the outside of any tenant’s premises, or at any point inside any tenant’s premises where the same might be visible outside of such premises, without the prior written consent of Landlord, which consent
shall not be unreasonably withheld. All approved signs or lettering shall be prepared, printed, affixed, or inscribed at the expense of the tenant and shall be of a size, color and style acceptable to Landlord. 

 

	5.	The windows that reflect or admit light and air into the halls, passageways or other public places in the Building shall not be covered or obstructed by any tenant, nor
shall any bottles, parcels or other articles be placed on the window sills. 

  

	6.	No showcases or other articles shall be put in front of or affixed to any part of the exterior of the Building, nor placed in the halls, corridors or vestibules.

			
	Exhibit “C”	  	Lake View Village

  

	7.	No bicycles, skateboard, vehicles, animals or birds of any kind shall be brought into or kept in or about the Building; however, bicycles may be kept in a bike rack
installed by the Landlord on the Building exterior. 

  

	8.	No noise, including, but not limited to, music or the playing of musical instruments, recordings, radio, television or similar audio or video device which, in the
judgment of Landlord, might disturb other tenants in the Building, shall be made or permitted by any tenant. 

  

	9.	No tenant, nor any tenant’s contractors, employees, agents, visitors, invitees, or licensees, shall at any time bring into or keep upon the premises or the
Building any inflammable, combustible, explosive, environmentally hazardous or otherwise dangerous fluid, chemical or substance. 

  

	10.	Additional locks or bolts of any kind which shall not be operable by the grand master key for the Building shall not be placed upon any of the doors or windows by any
tenant, nor shall any changes be made in locks or mechanism thereof which shall make such locks inoperable by such grand master key. Additional keys for a tenant’s premises and toilet rooms shall be procured only from the Landlord who may make
a reasonable charge therefore. 

  

	11.	All movement of freight, furniture, packages, boxes, crates or any other object or matter of any description must take place during such hours and in such elevators,
and in such manner as Landlord or its agents may determine from time to time. Any labor and engineering costs incurred by Landlord in connection with any moving herein specified, shall be paid by Tenant to Landlord, on demand.

  

	12.	Landlord shall have the right to prescribe the weight and position of safes and other objects of excessive weight, and no safe or other object whose weight exceeds the
lawful load for the area upon which it would stand shall be brought into or kept upon any tenant’s premises. If, in the judgment of Landlord, it is necessary to distribute the concentrated weight of any heavy object, the work involved in such
distribution shall be done at the expense of the tenant and in such manner as Landlord shall determine. 

  

	13.	No machinery or mechanical equipment other than ordinary portable business machines may be installed or operated in any tenant’s premises without Landlord’s
prior written consent which consent shall not be unreasonably withheld or delayed, and in no case shall any machines or mechanical equipment be so placed or operated as to disturb other tenants. Machines and mechanical equipment which may be
permitted to be installed and used in tenant’s premises shall be equipped, installed and maintained so as to prevent any disturbing noise, vibration or electrical or other interference from being transmitted from such premises to any other area
of the Building. 

  

	14.	Landlord, its contractors, and their respective employees, shall have the right to use, without charge therefor, electricity and water in the premises of any tenant
while making repairs or alterations in the premises of such tenant. 

			
	Exhibit “C”	  	Lake View Village

  

	15.	No premises of any tenant shall be used for lodging or sleeping or for any immoral or illegal purpose. 

 

	16.	The requirements of tenants for any services by Landlord will be attended to only upon prior application to the Landlord. Employees of Landlord shall not perform any
work or do anything outside of their regular duties, unless under special instructions from Landlord. 

  

	17.	Canvassing, soliciting and peddling in the Building are prohibited and each tenant shall cooperate to prevent the same. 

 

	18.	Without the prior written consent of Landlord, no tenant shall sell newspapers, magazines, periodicals, theater or travel tickets or other goods or merchandise to the
general public in or on tenant’s premises nor shall any tenant use or permit the use of any sidewalk for any similar purposes. 

  

	19.	Each tenant shall store its trash and garbage within its premises. No material shall be placed in the trash boxes or receptacles if such material is of such nature that
it may not be disposed of in the ordinary and customary manner of removing and disposing of office building trash and garbage in the City of Lake Oswego without being in violation of any law or ordinance governing such disposal. All garbage and
refuse disposal shall be made only through entryways provided for such purposes and at such times as Landlord shall designate. No tenant shall cause or permit any unusual or objectionable odors to emanate from its premises which would annoy other
tenants or create a public or private nuisance. No cooking shall be done in the premises of any tenant except as is expressly permitted in such tenant’s lease; and in any event said cooking shall not cause objectionable odors to permeate from
its premises which would annoy other tenants. Tenant’s operation of an employee kitchen containing a microwave and refrigeration shall not be considered a violation of this regulation. 

 

	20.	No coin vending machine, video game, coin or token operated amusement device or similar machine shall be used or installed in any tenant’s premises without
Landlord’s prior written consent. 

  

	21.	No bankruptcy, going out of business, liquidation or other form of distress sale shall be held in any of tenant’s premises. No sales shall be held outside of any
tenant’s premises. No advertisement shall be done by loudspeaker, barkers, flashing lights or displays or other methods not consistent with the character of a high-quality office building. 

 

	22.	Nothing shall be done or permitted in any tenant’s premises, and nothing shall be brought into or kept in any tenant’s premises, which would impair or
interfere with the economic heating, cleaning or other servicing of the Building or the premises, or the use or enjoyment by any other tenant of any other premises, nor shall there be installed by any tenant any ventilating, air conditioning,
electrical or other equipment of any kind which, in the reasonable judgment of Landlord, might cause any such impairment or interference. 

			
	Exhibit “C”	  	Lake View Village

  

	23.	No acids, vapors or other similar caustic materials shall be discharged or permitted to be discharged into the waste lines, vents or flues of the Building. The water
and wash closets and other plumbing fixtures in or serving any tenant’s premises shall not be used for any purpose other than the purposes for which they were designed or constructed, and no sweepings, rubbish, rages, acids or other foreign
substances shall be deposited therein. All damages resulting from any misuse of the fixtures shall be borne by the tenant who, or whose employees, agents, invitees, visitors or licensees shall have caused the same. 

 

	24.	All entrance doors in each tenant’s premises and windows shall be left locked when the tenant is not occupying the premises. Entrance doors to the tenant’s
premises shall not be blocked open at any time. Each tenant, before closing and leaving its premises at any time, shall turn out all lights. 

  

	25.	Hand trucks not equipped with rubber tires and side guards shall not be used within the Building. 

 

	26.	Tenant’s employees shall park only in those areas of the Project designated in writing by Landlord from time to time for such purpose. If requested, Tenant shall
furnish to Landlord in writing license numbers of vehicle of Tenant and employees. Any vehicle improperly parked by an employee of Tenant may be towed or otherwise removed by Landlord at Tenant’s expense and Tenant shall indemnify Landlord from
any liability in connection with such removal. 

  

	27.	Tenant shall be responsible for the observance of all of the foregoing rules and regulations by Tenant’s employees, agents, clients, customers, invitees, and
guests. 

  

	28.	Landlord reserves the right to rescind, modify, alter or waive any rule or regulation at any time prescribed for the Project when, in its reasonable judgment, it deems
it necessary, desirable or proper for the Project’ s best interest and for the best interests of the tenants generally, and no alteration or waiver of any rule or regulation in favor of one tenant shall operate as an alteration or waiver in
favor of any other tenant. Landlord shall not be responsible to any tenant for the non-observance or violation by any other tenant of any of the rules and regulations at any time prescribed for the Building. 

 

	29.	Landlord reserves the right to add to, modify or otherwise change these Rules and Regulations. Such changes shall become effective when written notice thereof is
provided tenants of the Building. 

  

	30.	These rules and regulations are in addition to, and shall not be construed in any manner to modify or amend, in whole or in part, the terms of any written lease for
space in the Project. 

 Lake View Village 

 

 RIDER: OPTION TO EXTEND 
 Terms of Option: 
 Tenant shall have an option to extend the term of this Lease
for one (1) additional period of one (1) year upon the same terms and conditions set forth herein; provided Tenant shall have delivered written notice to Landlord of the exercise of the option not more than 365 days nor less than 120 days
prior to the end of the initial Lease term and provided further that: 
  

	 	(a)	Tenant is not in default hereunder in the payment of rent or any other term or condition hereof at the time it gives such notice to Landlord or at the time the extended
term begins; and 

  

	 	(b)	The minimum monthly rent, as specified in Section 3.1 hereof, for such extended term shall be modified as follows: 

Months 25-36 $3,300.00 per month 
  

							
	LANDLORD:	 	TENANT:
		
	LO 138 LLC,	 	RXi PHARMACEUTICALS CORPORATION,
	an Oregon limited liability company	 	a Delaware corporation
				
	 By:
	 	 Gramor 138 LLC,
 an Oregon
limited liability company
 Manager
	 		 	
				
	By:	 	Gramor Investments, Inc.,	 		 	
		 	 an Oregon Corporation

Manager
	 		 	
				
	By:	 	 /s/ Barry A. Cain
	 	By:	 	 /s/ Mark J. Ahn

		 	Barry A. Cain, President	 		 	Mark J. Ahn, President/CEOLease Agreement, effective as of April 30, 2009

 Exhibit 10.45 
 TEXT MARKED BY [* * *] HAS BEEN OMITTED PURSUANT TO A REQUEST
FOR CONFIDENTIAL TREATMENT AND WAS FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION. 
  
 

 
 LICENSE AGREEMENT 
 THIS LICENSE AGREEMENT (this “Agreement”) is made and entered into by and between Apthera, Inc., a Delaware corporation having its principal offices at 8418 E. Shea Boulevard, Suite 100,
Scottsdale, Arizona 85260 USA (the “Licensor”), and Kwangdong Pharmaceutical Co., Ltd., a company incorporated in Korea having its principal offices at 1577-4 Seocho-Dong, Seoul, Republic of Korea (the “Licensee”),
with such foregoing entities also referred to hereafter individually as a “Party” or collectively as the “Parties.” The Agreement shall be effective as of the Effective Date. 

WHEREAS, the Licensor is the owner of or otherwise controls the Licensed Intellectual Property (as defined below); 

WHEREAS, Licensee desires to use, sell, offer for sale, and otherwise commercialize the products using the Licensed Intellectual Property
within the Licensed Fields (as defined below); 
 WHEREAS, Licensee desires to acquire and the Licensor desires to grant to
Licensee a license under the Licensed Intellectual Property; and 
 NOW, THEREFORE, in consideration of the mutual promises and
covenants contained in this Agreement and other valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties agree as follows: 
 1. Definitions. 
 1.1 Certain Definitions. The following terms shall
have the following respective meanings: 
 “Affiliates” shall mean, with respect to any specified Person, a
Person that directly or indirectly through one or more intermediaries, controls, or is controlled by, or is under common control with, the Person specified. 
 “Agreement” shall have the meaning set forth in the Introduction hereof. 
 “Bankruptcy” of either Party shall mean any of the following events: 
 (a) Such Party is unable to pay its debts as they come due or such Party fails to have assets (both tangible and intangible) with a fair salable value in excess of the amount required to pay the probable
liability on its respective existing debts for a period of more than ninety (90) days (“Insolvency”); 

 (b) The institution by such Party of proceedings to be adjudicated as bankrupt, or
insolvent or the consent by such Party to the institution of bankruptcy or Insolvency proceedings against such Party or the filing by such Party of a petition or answer or consent seeking reorganization or release under any applicable law, or the
consent by such Party to the filing of any such petition or the appointment of a receiver, liquidator, assignee, trustee, or other similar official of such Party, or of any substantial part of such Party’s property, or the making by such Party
of an assignment for the benefit of creditors, or the taking of action by such Party in furtherance of any such action; or 8418 E. Shea Blvd., Suite 100, Scottsdale, AZ 85260 www.apthera.com 

(c) The institution, consent, or the filing by (or against) such Party of any composition, reorganization, or bankruptcy liquidation
proceedings under applicable law. 
 “Claims” shall mean any claim, action, arbitration, proceeding, review,
audit, hearing, investigation, litigation, or suit (whether civil, criminal, administrative, investigative, informal, or threatened). 
 “Confidential Information” shall have the meaning set forth in the Mutual Confidential Disclosure Agreement. 
 “Disclosing Party” shall have the meaning set forth in the Mutual Confidential Disclosure Agreement. 
 “Effective Date” shall mean the date on which this Agreement is signed by the last Party to sign it. 
 “EMEA” shall mean the European Medicines Agency, and any successor thereto. 
 “FDA” shall mean the United States Food and Drug Administration, and any successor thereto. 
 “Field of Use” shall mean for the treatment of breast cancer. 

“Indemnified Party” shall mean the Party seeking indemnification. 

“Indemnifying Party” shall mean the Party indemnifying the Indemnified Party. 

“Infringes” shall mean impairs, dilutes, misappropriates, or otherwise violates. 

“Insolvency” shall have the meaning set forth in the definition of Bankruptcy hereof. 

“Intellectual Property” shall mean all intellectual property rights of any nature or form of protection of a similar
nature or having equivalent or similar effect to any of the foregoing, including, without limitation: (a) inventions, discoveries, processes, designs, techniques, developments, technology, and related improvements, whether or not patentable;
(b) United States patents, patent applications, divisional s, continuations, reissues, renewals, registrations, confirmations, re-examinations, certificates of inventorship, extensions, and the like, and any provision applications of any such
patents or patent applications, and any foreign or international equivalent of any of the foregoing; (c) any word, name, symbol, color, designation, or device or 

  
 2 

 
any combination thereof, including, without limitation, any United States or pending trademark, trade dress, service mark, service name, trade name, brand name, logo, domain name, or business
symbol, and any foreign or international equivalent of any of the foregoing and all goodwill associated therewith; (d) any work, whether or not registered in the United States or elsewhere, that incorporate, is based upon, derived from, or
otherwise uses any intellectual property, including, without limitation, mechanical and electronic design drawings (including, without limitation, computer-aided design files), specification, software (including, without limitation, documentation
and object and source code listing), processes, technical or engineering data, test procedures, schematics, writings, materials, products, artwork, packaging and advertising materials; and (e) technical, scientific, and other know-how and
information, trade secrets, knowledge, technology, means, methods, processed, practices, formulas, assembly procedures, computer programs, apparatuses, specifications, books, records, production data, publications, databases, reports, manuals, data
and results, in written, electronic, or any other form not known or hereafter developed. 
 “KFDA” shall mean
the Korea Food & Drug Administration and any successor thereto. 
 “Licensee” shall have the meaning
set forth in the Introduction hereof. 
 “Licensee Financial Records” shall have the meaning set forth in
Section 3.4 hereof. 
 “Licensee Indemnities” shall mean Licensee and its directors, officers, employees,
Affiliates and agents. 
 “Licensed Intellectual Property” shall mean any and all Intellectual Property related
to the Licensed Products as set forth on Exhibit B attached hereto, as may be amended from time to time by the mutual written agreement of the Parties. 
 “Licensed Products” shall mean any product which: (a) in the absence of the license granted in Section 2 hereof would infringe any of the Licensed Intellectual Property; or
(b) is made, at least in part, using any of the Licensed Intellectual Property. 
 “Licensed Territory”
shall mean the Republic of Korea. 
 “Licensor” shall have the meaning set forth in the Introduction hereof.

 “Licensor Indemnitees” shall mean the Licensor and its directors, officers, employees, Affiliates and
agents. 
 “Losses” shall mean all Claims, losses, liabilities, damages, costs, obligations, assessments,
penalties and interest, demands and expenses (including, without limitation, actual attorneys’ fees), whether direct or indirect, known or unknown, absolute or contingent (including, without limitation, settlement costs and any legal,
accounting and other expenses for investigation or defending any Claims). 
 “Mutual Confidential Disclosure
Agreement” shall mean that certain Mutual Confidential Disclosure Agreement entered into by and between the Licensor and Licensee, dated April 2, 2009 attached hereto as Exhibit A. 

  
 3 

 “Net Sales” shall mean Licensee’s invoice price for the sale of all
Licensed Products, less those taxes, duties, refunds, exchanges, promotional give-aways and shipping charges actually incurred by Licensee and separately stated on such invoice. 

“Party” or “Parties” shall have the meaning set forth in the Introduction hereof. 

“Persons” shall mean any individual, partnership, firm, corporation, association, trust, unincorporated organization, or
other entity, as well as any syndicate or group that would be deemed to be a person under Section 13(d) of the Securities Exchange Act of 1934, as amended. 
 “Phase III Clinical Trial” shall mean a clinical trial as defined in 21 C.F.R. 312.21(c), as may be amended from time to time, or any foreign equivalent thereto. A Phase III Clinical
Trial shall be deemed to have been initiated when the first patient is dosed in such Phase III Clinical Trial. 

“Quarterly Net Sales Report” shall have the meaning set forth in Section 3.5 hereof. 

“Receiving Party” shall have the meaning set forth in the Mutual Confidential Disclosure Agreement. 

“Regulatory Authority” shall mean, with respect to any particular country, territory or union, the governmental
authority, body, commission, agency or other instrumentality of such country, territory or union with the primary responsibility for the evaluation or approval of pharmaceutical products before such pharmaceutical product may be tested, marketed,
promoted, distributed or sold in such country, including such governmental bodies that have jurisdiction over the pricing of such pharmaceutical product. The term “Regulatory Authority” includes the KFDA, the FDA, and the European Agency
for the Evaluation of Medicinal Products or EMEA 
 “Reimbursement approval” shall mean the approval received
for any Licensed Product to be reimbursed by insurance. Once a Licensed Product is approved for reimbursement by insurance, the royalty rate for Reimbursable Net Sales shall apply to the Licensed Product. 

“Reimbursable Net Sales” shall mean the Net Sales for any Licensed Products that have been approved for reimbursement by
insurance. 
 “Non-reimbursable Net Sales” shall mean the Net Sales for any Licensed Products that have not
been approved for reimbursement by insurance. 
 “Royalties” shall have the meaning set forth in
Section 3.3 hereof. 
 “Term” shall have the meaning set forth in Section 12.1 hereof. 

2. License Grant. 
 2.1 Grant of License. Subject to the terms and conditions of this Agreement, the Licensor grants to Licensee and its Affiliates an exclusive, non-transferable license, limited to the Licensed
Territory and Field of Use, to the Licensed Intellectual Property to use, sell, offer for sale, or otherwise commercially exploit the Licensed Products supplied by Licensee within the Licensed Territory and Field of Use for the Term of this
Agreement. 

  
 4 

 2.2 Right to Sub-license. Licensee shall not have the right to sub-license any of the
Licensed Intellectual Property in accordance with Section 2.1 hereof without Licensor’s prior written consent and Licensor’s consent shall not be unreasonably withheld. 

2.3 Reservation of Rights. All rights in any Licensed Intellectual Property not granted by the Licensor to Licensee in Sections
2.1 and 2.2 hereof are expressly reserved to the Licensor and no additional licenses are granted or implied hereunder. 
 3.
Consideration and Reporting. 
 3.1 Equity Investment. Licensee shall make a [***] U.S. dollar
($[***]) equity investment in Licensor payable as follows: 
 (a) a [***] U.S. dollar
($[***]) investment in Series B-1 Preferred Equity Offering to be paid within fifteen (15) days after the Effective Date of the Agreement, and 
 (b) a four hundred thousand U.S. dollar ($400,000.00) investment to be paid within thirty (30) days from the date that the first patient is dosed in a Phase III clinical study with the investment to
be made in Licensor’s then current preferred equity offering; provided that the conditions of the aforesaid preferred equity offering shall be at least senior to or on parity with the conditions of the Licensor’s most senior preferred
equity at that time. 
 3.2 Milestone Payments. Licensee agrees to pay Licensor the following milestone payments:

 (a) [***] U.S. dollars ($[***]) to be paid within thirty (30) days of receiving
reimbursement approval in the Licensed Territory, 
 (b) [***] U.S. dollars ($[***]) to be paid
within thirty (30) days after Licensee achieves [***] U.S. dollars ($[***]) in Net Sales of all Licensed Products, and 
 (c) [***] U.S. dollars ($[***]) to be paid within thirty (30) days after Licensee achieves [***] U.S. dollars ($[***]) in Net Sales of all
Licensed Products. 
 3.3 Royalties. Licensee shall pay and the Licensor shall receive the following percents of the Net
Sales of all Licensed Products in the Licensed Territory for the Term of this Agreement (the “Royalties”): 

(a) for the first [***] U.S. dollars ($[***]) in Net Sales, Licensor shall receive [***]
([***]%) of Reimbursable Net Sales and [***] ([***]%) of Non-reimbursable Net Sales, 

(b) for Net Sales over [***] U.S. dollars ($[***]) and up to [***] U.S. dollars
($[***]), Licensor shall receive [***] percent ([***]%) of Reimbursable Net Sales and [***] percent ([***]%) of Non-reimbursable Net Sales, 

(c) for Net Sales over [***] U.S. dollars ($[***]), Licensor shall receive [***] percent
([***]%) of Reimbursable Net Sales and [***] percent ([***]%) of Non-reimbursable Net Sales. 
 The Royalties due under this Section 3.3 shall be paid within sixty (60) days after the end of the then-current quarter. 
 3.4 Financial Records and Auditing. Licensee shall, during the Term of this Agreement and for a period of one (1) fiscal year thereafter, keep and maintain financial statements and records
relating 

  
 5 

 
exclusively to the subject matter of this Agreement solely for the purposes of confirming the Net Sales of the Licensed Products to be reported according to Section 3.5 hereof (the
“Licensee Financial Records”). The Licensor, through an independent certified public accountant (provided that such independent certified public accountant is not compensated on a contingency basis), subject to a written
non-disclosure agreement with Licensee, shall have the right, during normal business hours and upon ten (10) days advance written notice to Licensee, and no more often than once per calendar year, to inspect the Licensee Financial Records.
Licensee shall have the right to have a representative present at all such inspections. The Licensor warrants that all such audits shall be carried out in a manner calculated not to unreasonably interfere with Licensee’s conduct of business.
Further, such certified public accountant agrees to comply with all of Licensee’s safety and security requirements during any visits to Licensee’s facilities. The cost of such inspection or audit shall be borne by the Licensor, unless such
inspection or audit reflects a discrepancy adverse to the Licensor of five percent (5%) or more in the Net Sales reported by Licensee. In the event that the inspection or audit reveals a discrepancy adverse to the Licensor of five percent
(5%) or more in the Net Sales reported by Licensee in accordance with this Agreement, Licensee shall be responsible for the reasonable costs of such inspection or audit. The Licensor acknowledges that the Licensee’s Financial Records
contain confidential trade information. Neither the Licensor nor its representatives shall at any time communicate to others or use any facts or information obtained as a result of such inspection or audit of the Licensee Financial Records. Under no
circumstances shall such independent certified public accountant provide the Licensor with any information regarding the identity of Licensee’s customers or provide the Licensor with any copies of Licensee’s customer lists. The
Licensor’s right to inspect the Licensee Financial Records shall be limited to the current year for which Net Sales of the Licensed Products are to be reported are payable and the immediately preceding one (1) fiscal year period.
Notwithstanding anything in this Agreement to the contrary, such audit right shall extend only one (1) fiscal year beyond termination of this Agreement. 
 3.5 Quarterly Reports. During the Term of this Agreement and for any calendar quarter in which Licensee or its Affiliates have made any sales of the Licensed Products, Licensee shall, within thirty
(30) days after the end of each such calendar quarter, furnish to the Licensor a written report showing the Net Sales of the Licensed Products during such quarter (the “Quarterly Net Sales Report”) including the following
specific information: (a) total Net Sales of the Licensed Products broken down into Reimbursable Net Sales and Non-reimbursable Net Sales categories as may be reasonably requested by the Licensor, and sufficient documentation to demonstrate the
calculation of such Net Sales; (b) the exchange rates used in determining the Net Sales in United States dollars; and (c) a comparison of forecast to actual sales of the Licensed Products, as customarily done by Licensee. 

3.6 Payments. All payments due pursuant to this Agreement shall be made in United States dollars. Any payments due pursuant to
this Agreement unpaid within the time period set forth in the corresponding Section shall bear interest at the rate of one and one-half percent (1.5%) per month or the highest amount permitted by law, whichever is lower, from the date when such
payment was due until payment in full, with interest, is made. 
 3.7 Withholding Taxes. Licensee shall make the payment
of the milestone and royalty payments owed to Licensor (defined in Sections 3.2 and 3.3) after deduction of withholding taxes that are imposed on such payments under the laws of the Licensed Territory and any of the bi-lateral tax treaties to which
the government of the Licensed Territory is a party. Licensee shall notify Licensor of any such withholding taxes and the Parties shall cooperate to receive any benefits under any double taxation treaty. 

4. Ownership of Intellectual Property. 
 4.1 Ownership of Licensed Intellectual Property. Licensee acknowledges and agrees, by and between the Parties, that the Licensor shall own all right, title and interest in and to the Licensed
Intellectual Property and Licensee shall have no rights thereto beyond the licenses granted in Sections 2.1 and 2.2 hereof. 

  
 6 

 4.2 Ownership of Improvements to Licensed Intellectual Property. Licensee
acknowledges and agrees, by and between the Parties, that Licensor shall own all right, title and interest in and to any improvements in the Licensed Intellectual Property regardless of which Party contributed to the improvements. Licensor agrees to
grant to Licensee and its Affiliates an exclusive, non-transferable license, limited to the Licensed Territory and Field of Use, to any such improvements in the Licensed Intellectual Property in accordance with the same terms and conditions that
apply to the licensed Intellectual Property. 
 5. Prosecution and Maintenance of Intellectual Property. 

5.1 Prosecution and Maintenance of Licensed Intellectual Property. The Licensor shall prosecute and maintain the Licensed
Intellectual Property. The Licensor shall be responsible for all costs, fees and other expenses related to such prosecution and maintenance (including, without limitation, outside counsel fees, patent, trademark and copyright office fees, annuities
and maintenance fees) with respect to any Licensed Intellectual Property. The Licensor shall file, prosecute and maintain the Licensed Intellectual Property, at the Licensor’s sole cost. The Licensor shall keep Licensee advised as to all
material developments with respect to all registrations and applications filed, prosecuted and maintained under this Section 5.1. 
 6. Product Development and Clinical Trials. 
 6.1 Costs and
Participation. Licensor shall be responsible for all product development costs and all costs for clinical trials, and recruit enough patients for filing with Regulatory Authorities in the Licensed Territory. Licensee shall advise on regulatory
aspects related to clearance of the sale of any Licensed Product in the Licensed Territory and Licensee shall participate in Phase III clinical trials in the Licensed Territory at sites mutually agreed upon by the Parties. 

6.2 Information and Data used for Regulatory Purposes. Licensor shall deliver to Licensee documents, information and data which
are and will remain in Licensor’s possession and owned or controlled by Licensor and its Affiliates, which Licensor deems may be reasonably needed by Licensee in developing, registering, and marketing the Licensed Product in the Licensed
Territory. During the term of this Agreement, Licensor shall from time to time inform Licensee of new information which Licensor may deem to be useful for Licensee in the development and sale of the Licensed Product in the Licensed Territory.

 7. Cost and Supply of Licensed Product. 
 7.1 Cost. Licensor shall supply Licensee with Licensed product known as the commercial product NeuVax (E75 peptide in combination with GM-CSF) as a packaged finished product at a price not to
exceed [***] U.S. dollars ($[***]) per dose under the terms of a Supply Agreement to be agreed upon by both Parties after the Licensed Product NeuVax is approved for sale in the Licensed Territory. This price can be
adjusted for inflation on an annual basis based on rates set by the U.S. Bureau of Labor Statistics. If an adjuvant biologically similar to GM-CSF becomes available and approved to be packaged with E75, Licensor will supply such packaged product to
Licensee at Licensor’s cost plus [***] ([***]%) of Licensor’s costs, provided that the sale of the commercial product NeuVax has been launched by Licensee in the Licensed Territory for a period of at least five
(5) years. 
 7.2 Supply. Licensor agrees to supply Licensee with the Licensed Product having more than 90% of shelf
life remaining, within 3 months after its acceptance of the orders. Licensor shall guarantee the Licensed Product was manufactured in a qualified GMP facility of Licensor or any of its subcontractors. 

  
 7 

 8. Representations, Warranties and Covenants. 

8.1 Representations and Warranties. 
 (a) The Licensor’s Representations and Warranties. The Licensor represents and warrants as follows: 
 (i) The Licensor has all necessary legal power, right and authority to enter into and perform its obligations under this Agreement and has taken all necessary corporate action under the laws of the State
of Delaware and its certificate of incorporation and bylaws to authorize the execution of this Agreement and the consummation of the transactions contemplated hereunder. 
 (ii) No Claim has been brought or is threatened by any third party with respect to any Licensed Intellectual Property that alleges that such Licensed Intellectual Property Infringes the rights of any
third party. 
 (iii) The Licensor has not threatened or initiated any Claim against any third party alleging that such third
party Infringes any Licensed Intellectual Property. 
 (iv) The Licensor has taken all reasonable measures to protect and
preserve the security, confidentiality and value of all Licensed Intellectual Property, including, without limitation, trade secrets and other Confidential Information. 
 (v) The Licensor has not previously granted any rights to any third party that are inconsistent with the rights granted to Licensee under this Agreement. 

(b) Licensee’s Representations and Warranties. Licensee represents and warrants that Licensee has all necessary legal power to
enter into and perform its obligations under this Agreement and has taken all necessary corporate action under all applicable Korean laws and its certificate of incorporation and bylaws to authorize the execution of this Agreement and the
consummation of the transactions contemplated hereunder. 
 8.2 Covenants. 

(a) The Licensor’s Covenants. The Licensor covenants as follows: 

(i) The Licensor will comply with all applicable laws and regulations with respect to the Licensed Intellectual Property, the Licensed
Products, and this Agreement. 
 (ii) The Licensor will take every reasonable action to preserve the security, confidentiality
and value of all Licensed Intellectual Property. 
 (iii) The Licensor will ensure that all of its employees, consultants, or
agents involved in creation of the Licensed Intellectual Property on behalf of the Licensor shall assign to the Licensor all of their right, title and interest in and to such Licensed Intellectual Property. 

(iv) The Licensor will not grant for the Term of this Agreement any rights to any third party that are inconsistent with the rights
granted to Licensee under this Agreement. 
 (v) The Licensor will collaborate with the Licensee in good faith if the Licensee
requests any supports for the successful marketing of the Licensed Products in the Licensed Territory. 
 (b) Licensee’s
Covenants. Licensee covenants that it will comply with all applicable laws and regulations with respect to the Licensed Intellectual Property and the Licensed Products. 

  
 8 

 8.3 DISCLAIMER. EXCEPT AS EXPRESSLY SET FORTH IN THIS ARTICLE 8 HEREOF, NO PARTY
MAKES ADDITIONAL WARRANTIES, REPRESENTATIONS, OR COVENANTS EXPRESS, IMPLIED, OR STATUTORY AS TO ANY OTHER MATTER WHATSOEVER. 

9. Infringement. 
 9.1 Notice of Infringement. Each Party shall immediately notify the other Party in writing of any known or alleged infringement(s) of the Licensed Intellectual Property and the Licensed Products
and shall immediately inform the other Party of any evidence of any such infringement(s). 
 9.2 Enforcement of Licensed
Intellectual Property. The Licensor shall have the first right, but not the obligation, to enforce any of the Licensed Intellectual Property against any third party. Licensee agrees to join as a party plaintiff in any Claim initiated by the
Licensor if requested by the Licensor, at the sole cost of the Licensor, and Licensee shall provide the Licensor all assistance the Licensor may reasonably request in any such Claim, at the sole cost of the Licensor. In the event that the Licensor
fails or decides not to enforce such Licensed Intellectual Property within thirty (30) days after written notice of such possible infringement, the Licensor shall give Licensee written notice of the decision or failure to take action and
Licensee shall have the right, but not the obligation to undertake such Claim in its own name, on its own behalf, and at its own cost; provided, however, that the Licensor shall join as a party plaintiff in any such Claim initiated by Licensee if
requested by Licensee, at the equal share of the cost of Licensor and Licensee, and the Licensor shall provide Licensee all assistance Licensee may reasonably request in any such Claim, at the equal share of the cost of Licensor and Licensee.

 9.3 No Settlement. Notwithstanding anything in this Agreement to the contrary, under no circumstances shall either
Party settle or resolve any Claims of or by the Licensed Intellectual Property and/or the Licensed Products without the express written consent of the other Party, of which such consent shall not be unreasonably withheld, delayed, or conditioned.

 10. Indemnification. 
 10.1 Indemnification by Licensor. The Licensor shall defend, indemnify and hold harmless Licensee Indemnitees from and against any and all Losses which any Licensee Indemnitee may suffer or incur
by reason of: 
 (a) Any breach by the Licensor of any of its representations, warranties, agreements, or covenants contained
in this Agreement or by the willful misconduct of the Licensor, including, without limitation, by way of any misappropriation, willful misstatement, or fraud on any government authority; 

(b) Any third party Claim of harm or injury arising out of, related to, or in connection with a product recall or the manufacture of the
Licensed Products that is attributable to any Licensed Product provided by Licensor. 
 10.2 Indemnification by Licensee.
Licensee shall defend, indemnify and hold harmless the Licensor Indemnitees from and against any and all Losses, which any Licensor Indemnitee may suffer or incur by reason of: 

(a) Any breach by Licensee of its representations, warranties, agreements, or covenants contained in this Agreement or by the willful
misconduct of Licensee, including, without limitation, by way of any misappropriation, willful misstatement, or fraud on any government authority. 

  
 9 

 10.3 Indemnification Procedures. 

(a) The Indemnified Party pursuant to this Article 10 shall promptly notify the Indemnifying Party, in writing, of such Claim describing
such Claim in reasonable detail; provided, however, that the failure to provide such written notice shall not affect the obligations of the Indemnifying Party unless and only to the extent it is actually prejudiced thereby. 

(b) The Indemnifying Party shall have a right within thirty (30) days after receipt of such written notice to take control, through
counsel of its own choosing (but reasonably acceptable to the Indemnified Party) and at its own cost, the settlement, or defense thereof unless: (i) the Indemnifying Party is also a party to the proceeding and the Indemnified Party determines
in good faith that joint representation would be inappropriate; or (ii) the Indemnifying Party fails to provide reasonable assurance to the Indemnified Party of its financial capacity to defend such proceeding, and provide indemnification with
respect thereto. The Indemnifying Party shall not, without the written consent of the Indemnified Party (which consent shall not be unreasonably withheld, delayed, or conditioned), settle or compromise any Claim, unless such settlement or compromise
includes an unconditional release of the Indemnified Party. If the Indemnifying Party does not notify the Indemnified Party within thirty (30) days after the receipt of written notice of a Claim of indemnity hereunder that it elects to
undertake the defense thereof, the Indemnified Party shall have the right to contest, settle, or compromise the Claim but shall not pay or settle any such Claim without the consent of the Indemnifying Party (which consent shall not be unreasonably
withheld, delayed, or conditioned). 
 (c) The Indemnifying Party and the Indemnified Party shall cooperate fully in all
aspects of any investigation, defense, pre-trial activities, trial, compromise, settlement, or discharge of any Claim in respect of which indemnity is sought pursuant to this Article 10, including, without limitation, providing the other Party with
reasonable access to employees and officers (including, without limitation, as witnesses) and other information. The remedies provided in this Article 10 shall not be exclusive of or limit any other remedies that may be available to the Indemnified
Parties. 
 (d) The Indemnifying Party shall reimburse the Indemnified Party for all Losses within five (5) days of
receipt of written notice from the Indemnified Party setting forth the amount of such Losses. The Indemnified Party shall also have a right to offset such Losses against any payment due to the Indemnifying Party. 

11. Confidential Information. 
 11.1 Confidential Information Generally. The existence and terms and conditions of this Agreement are confidential, and neither Party may make any disclosures regarding this Agreement without the
express prior written consent of the other Party, except: 
 (a) As may be required by law or legal process; 

(b) During the course of litigation so long as the disclosure of such terms and conditions are restricted in the same manner as is the
confidential information of other litigating parties and so long as: (i) the restrictions are embodied in a court-entered protective order; and (ii) the Disclosing Party informs the Receiving Party in writing in advance of the disclosure;
or 
 (c) In confidence to its legal counsel, accountants, banks and financing sources and their advisors solely in connection
with complying with financial transactions. 
 11.2 Restrictions on Confidential Information. 

(a) The Receiving Party agrees not to disclose any Confidential Information of the Disclosing Party and to maintain such Confidential
Information in strictest confidence, to take all reasonable precautions to prevent its unauthorized dissemination and to refrain from sharing any or all of the 

  
 10 

 
information with any third party for any reason whatsoever except as required by court order, both during and after the Term of this Agreement. Without limiting the scope of this duty, the
Receiving Party agrees to limit its internal distribution of the Confidential Information of the Disclosing Party only on a “need to know” basis solely in connection with the performance of this Agreement, and to take steps to ensure that
the dissemination is so limited. 
 (b) The Receiving Party agrees not to use the Confidential Information of the Disclosing
Party for its own benefit or for the benefit of any third party other than in accordance with the terms and conditions of this Agreement. 
 (c) All the Licensor’s Confidential Information remains the sole property of the Licensor and all Licensee’s Confidential Information remains the sole property of Licensee. 

(d) Upon written request of the Disclosing Party, or upon the expiration or other termination of this Agreement for any reason
whatsoever, the Receiving Party agrees to return to the Disclosing Party all such provided Confidential Information, including, without limitation, all copies thereof. 
 11.3 Survival. The obligations set forth in this Article 11 shall apply throughout the Term of this Agreement and for a period of five (5) years after the termination or expiration of this
Agreement or any extensions hereof. 
 12. Term and Termination. 

12.1 Term. This Agreement shall commence on the Effective Date, and, unless extended by the mutual written agreement of the Parties
(and then only upon the terms and conditions set forth herein) or sooner terminated in accordance with Section 12.2 hereof, shall continue for a period of 15 years from the launch of the sale of any Licensed Product in the Licensed Territory or
until the expiration or invalidation of the last valid claim in the Licensed Intellectual Property in the Licensed Territory, whichever occurs later (the “Term”). This Agreement shall be automatically renewed thereafter on a yearly
basis, unless terminated pursuant to the terms of this Agreement. 
 12.2 Early Termination. Upon the occurrence of any
of the following, this Agreement may be terminated by: 
 (a) Either Party immediately upon written notice to the other Party
if the other Party breaches any material provision of this Agreement and such breach is: (i) incapable of cure; or (ii) capable of cure, but not cured within ninety (90) days of the breaching Party’s receipt of written notice of
such default from the non-breaching Party. 
 (b) Either Party immediately upon the Bankruptcy of the other Party. 

(c) The Licensor immediately if Licensee does not pay the Consideration as described in Article 3 hereof within ninety (90) days of
the Licensor’s written notice of such non-payment. 
 (d) The Licensee if no Licensed Product is approved for sale in the
Licensed Territory. 
 (e) Mutual written agreement of the Parties. 

12.3 Effect of Early Termination: Upon expiration or early termination of this Agreement by the Licensor or Licensee pursuant to
Section 12.2 hereof, the rights granted hereunder shall immediately terminate; provided, however, that Licensee shall be permitted to use the Licensed Intellectual Property for a 

  
 11 

 
period of three (3) months to complete deliveries on contracts in force as of the date of termination, to sell and to otherwise dispose of any existing inventory of the Licensed Products
provided under this Agreement. 
 12.4 Survival. Expiration or early termination of this Agreement shall not relieve
either Party of its obligations incurred prior to the expiration or early termination. The following provisions shall survive expiration or early termination of this Agreement or of any extensions thereof for a period of five (5) years or for
such period of time as indicated in the surviving provision: Sections 4, 8, 10, 11, 13 hereof, Section 12.3 hereof and this Section 12.4. 
 13. Miscellaneous. 
 13.1 Notices. All notices, requests, demands and
other communications required to or permitted to be given under this Agreement shall be in writing and shall be conclusively deemed to have been delivered: (a) when hand delivered to the other Party; (b) when received when sent by
facsimile at the address and number set forth below (provided, however, any notice given by facsimile shall be deemed received on the next business day if such notice is received after 5:00 p.m. recipient’s time, or on a non-business day);
(c) three (3) business days after the same have been deposited in a United States post office with first class or certified mail return receipt requested postage prepaid and addressed to the Parties as set forth below; or (d) the next
business day after the same have been deposited with a nationally recognized overnight delivery service (i.e., Federal Express, DHL, or United Parcel Service) postage prepaid, addressed to the Parties as set forth below with next business-day
delivery guaranteed. For the purposes of this Agreement, the delivery addresses of the Parties are: 
 If to the Licensor:

 Apthera, Inc. 
 8418 E. Shea Boulevard 
 Suite 100 

Scottsdale, Arizona 85260 
 USA 
 Attention: Robert E. Kennedy, CFO 

Phone: (480) 348-9705 
 Facsimile: (480) 348-9709 
 If to Licensee: 

Kwangdong Pharmaceutical Co., Ltd. 
 1577-4 Seocho-Dong 
 Seoul, Republic of Korea 

Attention: [Bo Hyung Lee, Director] 
 Phone: [82-2-2025-1360] 
 Facsimile: [82-2-2025-1350] 

Each Party shall make an ordinary, good faith effort to ensure that it will accept or receive notices that are given in accordance with
this Section 11.1, and to ensure that the receiving Party actually receives such notice. A Party may change or supplement the addresses given above, or designate additional addresses by giving the other Party written notice of the new address
in the manner set forth above. Any correctly addressed notice that is refused, unclaimed, or undeliverable because of an act or omission of the Party to be notified shall be deemed effective as of the first date that said notice was refused,
unclaimed, or deemed undeliverable by the postal authorities, messenger, or overnight delivery service. 
 13.2 Entire
Agreement. This Agreement, together with any exhibits and schedules attached hereto and incorporated herein by this reference, and any other agreements entered into pursuant to 

  
 12 

 
this Agreement, constitute the entire agreement between the Parties pertaining to the subject matter contained herein, and supersede all prior or contemporaneous agreements, representations and
understandings of the Parties. 
 13.3 Delays or Omissions. No delay or omission to exercise any right, power, or remedy
accruing to either Party upon any breach or default under this Agreement shall impair any such right, power, or remedy of such Party, nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any
similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. Any waiver, permit, consent, or approval of any kind or
character on the part of either Party of any breach or default under this Agreement, or any waiver on the part of either Party of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent
specifically set forth in such writing or as provided in this Agreement. All remedies, either under this Agreement or by law or otherwise afforded to either Party, shall be cumulative and not alternative. 

13.4 Severability. This Agreement shall be deemed severable, and the invalidity or unenforceability of any term or provision
hereof shall not affect the validity or enforceability of this Agreement or of any other term or provision hereof. Furthermore, in lieu of any such invalid or unenforceable term or provision, the Parties intend that there shall be added as a part of
this Agreement a provision as similar in terms to such invalid or unenforceable provision as may be possible to be valid and enforceable. 
 13.5 Governing Law. This Agreement shall be governed by, and construed and enforced in accordance with the internal laws of the State of Arizona without regard to its conflict of laws provisions.
The Parties expressly and irrevocably consent to the exclusive personal jurisdiction and venue of the federal courts sitting within the County of Maricopa, Arizona, unless no federal subject matter jurisdiction exists, in which case the Parties
consent to the exclusive jurisdiction and venue in the Superior Court of Maricopa County, Arizona. The Parties expressly waive all defenses of lack of personal jurisdiction and forum non conveniens with respect to the federal and state courts
sitting within the County of Maricopa, Arizona. 
 13.6 Commercial Impracticability. No Party shall be liable for any
failure to perform its obligations in connection with any action described in this Agreement, only if such failure directly results from and is caused by any act of God, riot, war, terrorist attack, civil unrest, flood, earthquake, or other causes
beyond such Party’s reasonable control, excluding a Party’s financial condition or negligence. 
 13.7 Successors
and Assigns; No Third Party Beneficiaries. Neither this Agreement nor any of the rights or obligations arising under this Agreement may be assigned or transferred by either Party, in whole or in part, without the prior written consent of the
other Party, and any attempted assignment or transfer without such written consent shall be of no force or effect. 
 13.8
Entire Agreement; Amendment. Neither this Agreement nor any term hereof may be amended, waived, discharged, or terminated other than by a written instrument signed by the Party against whom enforcement of any such amendment, waiver,
discharge, or termination is sought. 
 13.9 Construction; Headings. The article, section and subsection headings in this
Agreement are inserted for convenience only and will not affect in any way the meaning or interpretation of this Agreement. The language of this Agreement shall be construed simply and according to its fair meaning, and shall not be construed for or
against any Party hereto as a result of the source of its draftsmanship. 
 13.10 Counterparts. This Agreement may be
executed in any number of counterparts, each of which will be deemed an original, but all of which together will constitute one instrument. Signatures transmitted electronically or by facsimile will be deemed original signatures. 

  
 13 

 13.11 Independent Contractor. Each Party is an independent contractor and is not and
shall not be deemed to be the legal representative or agent of the other Party for any purpose whatsoever, and neither Party is authorized by the other Party to transact business, incur obligations (express or implied), bill goods, or otherwise act
in any manner, in the name or on behalf of the other Party, or to make any promise, warranty, or representation in the name or on behalf of the other Party except as permitted in this Agreement. 

13.12 Injunctive Relief and Equitable Relief. The Parties acknowledge that a breach of any of the provisions set forth in Article
11 hereof shall result in irreparable and continuing damage for which there shall be no adequate remedy at law, and the non-breaching Party shall be entitled to injunctive relief and/or a decree for specific performance, and such other relief as may
be proper (including, without limitation, monetary damages if appropriate). 
 13.13 Further Assurances. Each Party
hereto shall promptly execute and deliver such further instruments and take such further actions as any other Party hereto may reasonably require or request in order to carry out the intent of this Agreement and to consummate the transactions
contemplated hereby. 
 [The remainder of this page has been intentionally left blank; signature page follows.] 

  
 14 

 IN WITNESS WHEREOF, the Parties hereto have duly executed this Agreement as of the Effective
Date. 
  

			
	APTHERA, INC.
		
	By:	 	 /s/ Robert E. Kennedy

	Name:	 	Robert E. Kennedy
	Title:	 	CFO
	Date:	 	April 22, 2009
	
	KWANGDONG
	PHARMACEUTICAL CO., LTD.
		
	By:	 	 /s/ Soo Boo Choi

	Name:	 	Soo Boo Choi
	Title:	 	Chairman
	Date:	 	April 30, 2009

  
 15 

 EXHIBIT A 
 Non-Disclosure Agreement 

 MUTUAL CONFIDENTIAL DISCLOSURE AGREEMENT 

This MUTUAL CONFIDENTIAL DISCLOSURE AGREEMENT (hereinafter referred to as “Agreement”), effective as of the 2nd day of April, 2009 (the
“Effective Date”), is made by and between: 
 Kwangdong Pharmaceutical Co., Ltd., a Korean corporation having its principal
offices at 1577-4 Seocho-Dong, Seoul, Republic of Korea, hereinafter referred to as “COMPANY” 
 and 

Apthera, Inc., a Delaware corporation having its principal place of business at 8418 Shea Blvd., Suite 100, Scottsdale, Arizona 85260-6667,
hereinafter referred to as “Apthera” 
 Hereinafter sometimes individually referred to as ‘Party’ and collectively as
‘Parties’. The party disclosing the Information shall hereinafter referred to as the ‘Disclosing Party’ and the party receiving such Information shall be referred to as the ‘Receiving Party’ 

WITNESSETH 
 WHEREAS, Apthera and COMPANY
wish to discuss a potential business, scientific and/or technical relationship between them (hereinafter referred to as the “Purpose”); and 
 WHEREAS, during the course of such discussions, it may become desirable or necessary for the Parties hereto to disclose to each other certain technical, commercial or business information of a
proprietary or confidential nature (hereinafter referred to as “Confidential Information”); and 
 WHEREAS, Parties hereto are
willing to provide for the conditions of such disclosure of Confidential Information and the rules governing the use and the protection thereof; 
 NOW, THEREFORE, Apthera and COMPANY, intending to be legally bound, hereby agree as follows: 
  

	1.	As used in this Agreement the term “Confidential Information” shall mean all information including, where appropriate and without limitation, licenses,
business plans and data (including financial, manufacturing, marketing, operations and strategic information), other data (including engineering, scientific and technical information), patent disclosures, patent applications, unpublished findings,
know how, techniques, processes, structures, methods, models, specifications, designs, drawings, algorithms, formulae, programs, samples, compositions, biological material, and compounds relating to the same disclosed by the Disclosing Party to the
Receiving Party or obtained by the Receiving Party through observation or examination of information or any means of disclosing such Proprietary Information that the Disclosing Party hereto may select to use during the life of this Agreement, but
only to the extent that such information is maintained as confidential by the Disclosing Party and is marked or otherwise identified as “Confidential” when disclosed to the Receiving Party. In the case of information given verbally, such
Confidential Information must be reduced to written form within 30 days of disclosure and likewise marked “Confidential”. 

  

	2.	During the period in which this Agreement is effective and also during the period stated in Section 13 below, each Party is obliged to treat all Confidential
Information supplied or disclosed by the Disclosing Party as strictly confidential and secret. Each Party shall use such Confidential Information only for the Purpose and shall safeguard any such Confidential Information as it safeguards its own
confidential information and shall refrain from unauthorized use by or disclosing it to third parties or disclosing it in any other way. Furthermore, Parties will ensure every reasonable precaution to prevent the unauthorized disclosure of said
Confidential Information. 

	3.	Parties may only disclose or reveal the Confidential Information to the minimum number of employees of Parties who have a need to know and solely for the Purpose or,
with prior written approval of the Disclosing Party, to the minimum of employees of companies associated with the other Party or its advisors who are actually engaged in the execution of activities requiring access to the Confidential Information,
on the condition that the Receiving Party has in force an appropriate confidentiality agreement with such advisors and associated company and their employees have signed appropriate agreements requiring them to treat the Confidential Information as
strictly confidential, and treat such Confidential Information in accordance with this Agreement. 

  

	4.	The Confidential Information of each Party, or any part thereof, whether capable of being copyrighted, patented, or otherwise registered by law, or not, is for the
purpose of this Agreement acknowledged by the Receiving Party as being the sole property of the Disclosing Party. Upon termination or expiration as set forth in Section 13 below, or at such earlier time as it appears that the Confidential
Information is no longer required, each Party shall, at its own expense, return to the other Party the originals and all copies of such Confidential Information within a reasonable time or, if requested by the Disclosing Party, shall destroy or
return the originals and all copies of such Confidential Information and certify to the destruction or return in writing within thirty (30) days of the request thereto. Notwithstanding any contrary foregoing provision, the Receiving Party may
retain one copy of Confidential Information in a secure location with appropriately restricted access for evidentiary purposes. The parties acknowledge that it may not be feasible to remove copies of information in electronic systems, such as email
and system archives and certain electronic media, and their continued presence shall not be a breach of this obligation so long as such copies are treated as confidential. 

 

	5.	The Receiving Party shall not analyze, copy, reverse engineer, or otherwise attempt to derive the composition or underlying information of any Confidential Information.

  

	6.	The Receiving Party shall have no obligations or restrictions with respect to any Confidential Information, which the Receiving Party can prove:

  

	 	a.	is or has become publicly and generally available or ascertainable prior to, or after the disclosure thereof and in such case through no wrongful act of the Receiving
Party; or 

  

	 	b.	is already known to the Receiving Party, as evidenced by written documentation in its files; or 

 

	 	c.	has been lawfully received at any time from a third party that the Receiving Party reasonably believes possesses such information lawfully and has the right to disclose
such information; or 

  

	 	d.	has been or is published without violation of this Agreement; or 

  

	 	e.	is independently developed in good faith by employees of the Receiving Party who did not have access to, nor had knowledge of the Confidential Information; or

  

	 	f.	is approved for release or use by written authorization of the Disclosing Party; or 

 

	 	g.	is required to be disclosed by applicable law, regulations or order of a governmental authority, agency or court of competent jurisdiction provided that the Receiving
Party takes reasonable steps to avoid disclosure or minimize its extent and promptly notifies the other Party of such order to provide that Party sufficient time to seek a protective order or other remedy to protect such Confidential Information.
The Receiving Party may disclose only the minimum Confidential Information required to be disclosed, whether or not a protective order or other remedy is in place. 

  
 2 

 The Confidential Information shall not be deemed to be within one of the foregoing
exceptions merely because it is embraced by more general information within the exception. In addition, any combination of features shall not be deemed to be within one of the foregoing exceptions merely because individual features are within the
exception but only if the combination itself is within the exception. The Receiving Party shall have the burden of proof in establishing any of the above-mentioned exceptions. 

 

	7.	Nothing contained in this Agreement shall be construed as granting or conferring any rights by license or otherwise to the Receiving Party, expressed or implied, for
any patent, trademark, copyright, know-how, invention or other intellectual property, discovery or improvement prior to or after the date of this Agreement, whether or not related to the subject matter of the Agreement. All Confidential Information
disclosed by one Party to the other shall remain the intellectual property of the Disclosing Party. Furthermore while each Party hereto agrees to act in good faith in disclosing information, which is accurate and adequate for the purpose set forth
herein, neither Party provides any warranty as to the accuracy and completeness of the information disclosed by it hereunder. 

  

	8.	Nothing in this Agreement may be construed as compelling either Party hereto to disclose any Confidential Information to the other, or to enter into any further
contractual relationship relating to the subject matter of this Agreement. 

  

	9.	Each Party hereto, to the extent of its right to do so, shall disclose to the other Party only such Confidential Information, which the Disclosing Party deems
appropriate to fulfill the objectives of this Agreement. Any information or data in whatever form disclosed by either Party hereto to the other shall be subject to the relevant terms and conditions of this Agreement. 

 

	10.	The Receiving Party shall be liable to Disclosing Party for any and all damages suffered by Disclosing Party arising out of or in relation to any breach of the
Receiving Party undertakings herein. The Receiving Party understands that any violation of this Agreement may cause immediate and irreparable harm to the Disclosing Party, which monetary damages cannot adequately remedy. Without prejudice to rights
and remedies available to the Disclosing Party, Receiving Party agrees that injunctive relief may be sought against it, in order to remedy, or to prevent a violation hereof. 

 

	11.	For each and every breach of this Agreement the Disclosing Party shall have the right to seek specific performance and other injunctive and equitable relief.

  

	12.	The execution, existence and performance of this Agreement shall be kept confidential by the Parties hereto and shall not be disclosed by either Party without the prior
written consent of the other. 

  

	13.	In consideration of the Purpose, Parties shall exchange Confidential Information within one (1) year of signing this Agreement. That if, on whatever grounds, an
agreement between Parties would not be entered into, this Agreement shall be terminated automatically after one (1) year and the obligations set forth in this Agreement are continuing and shall survive the termination of any discussions,
evaluations, negotiations or this Agreement and remain in full effect for a period of five (5) years from the date of termination. In the event the Parties enter into an agreement related to the Purpose, this Agreement shall continue in full
effect until the longer of one (1) year of signing this Agreement or the expiration of such agreement related to the Purpose, and the obligations set forth in this Agreement are continuing and shall survive the termination of this Agreement and
remain in full effect for a period of five (5) years from the date of termination. 

  
 3 

	14.	The Agreement shall be governed by and construed in accordance with the laws of the State of Arizona, USA, without regard to the conflict of law principles thereof.

  

	15.	None of the terms of this Agreement shall be amended or modified except in writing and signed by persons authorized to bind Parties. 

 

	16.	This Agreement shall be binding upon and inure to the benefit of each of the Parties, their successors, legal representatives, and assigns. A Party may assign this
Agreement only to a successor of that Party to that portion of its business relating to the subject matter of this Agreement and only after written approval of the contracting Party under this Agreement. However, such assignment shall not relieve
said Party of any of the obligations of confidentiality set forth above. 

  

	17.	This Agreement may be rendered effective through facsimile or other electronic transmission and/or may be executed in counterparts, each of which shall be deemed an
original, and all of which together shall constitute one and the same instrument. 

 IN WITNESS WHEREOF,
the Parties hereto have executed this Agreement as of the Effective Date. 
  

			
	APTHERA, INC.	  	Kwangdong Pharmaceuticals, Co., Ltd.
		
	 /s/ Robert E. Kennedy
	  	 /s/ Bo-Hyung Lee

	Signature	  	Signature
		
	 Robert E. Kennedy
	  	 Bo-Hyung Lee

	Name	  	Name
		
	 CFO
	  	 Director, Business Development

	Title	  	Title

  
 4 

 EXHIBIT B 
 Licensed Intellectual Property 
 PATENTS 

Issued Patents 
  

							
	 Patent Number
	  	 Title of Patent
	  	Jurisdiction	  	Filing Date
	 6,514,942
	  	Methods And Compositions For Stimulating T-Lymphocytes	  	U.S.	  	3/14/95
	 6,096,313
	  	Compositions Containing Immunogenic Molecules and Granulocyte-Macrophage Colony Stimulating Factor, as an Adjuvant	  	U.S.	  	2/9/96

 Pending Patent Applications 

 

							
	 Application Number
	  	 Title of Patent
	  	Jurisdiction	  	Filing Date
	 10/507,009
	  	Controlled modulation of amino acid side chain length of peptide antigens	  	U.S.	  	3/28/05
	 60/941,524
	  	Vaccine for the Prevention of Breast Cancer Relapse	  	U.S.	  	6/1/07
	 PCT/US08/60044
	  	Vaccine for the Prevention of Breast Cancer Relapse	  	PCT	  	4/11/08

 TRADEMARKS 
 U.S. Serial No. 77/107,771 filed February 14, 2007 for the mark “NEUVAX”.

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