Document:

Amended and Restated 1995 Stock Option Plan

 EXHIBIT 10.7 
  
 AMENDED & RESTATED 
  
 1995 STOCK OPTION PLAN 
  
 of 
  
 METROPCS, INC.  
  
 ARTICLE ONE 
  
 GENERAL PROVISIONS  
  
 I. PURPOSE OF
THE PLAN 
  
 This Plan is intended to promote the interests
of MetroPCS, Inc. (formerly General Wireless, Inc.), a Delaware corporation, by providing eligible persons with the opportunity to acquire a proprietary interest, or otherwise increase their proprietary interest, in the Corporation as an incentive
for them to remain in the service of the Corporation. 
  
 Capitalized terms herein shall have the meanings assigned to such terms in the attached Appendix A. 
  
 II. ADMINISTRATION OF THE PLAN 
  
 A. The Plan shall be administered by the Board. However, any or all administrative functions otherwise exercisable by the Board may be delegated to the
Committee. Members of the Committee shall serve for such period of time as the Board may determine and shall be subject to removal by the Board at any time. The Board may also at any time terminate the functions of the Committee and reassume all
powers and authority previously delegated to the Committee. 
  
 B.
The Plan Administrator shall have full power and authority (subject to the provisions of the Plan) to establish such rules and regulations as it may deem appropriate for proper administration of the Plan and to make such determinations under, and
issue such interpretations of, the Plan and any outstanding options as it may deem necessary or advisable. Decisions of the Plan Administrator shall be final and binding on all parties who have an interest in the Plan or any option or shares issued
thereunder. 
  
 III. ELIGIBILITY 
  
 A. The persons eligible to receive option grants under the Plan are as
follows: 
  
 (i) Employees, 
  
 (ii) non-employee members of the Board or the non-employee members of the
board of directors of any Parent or Subsidiary, and 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 1 

 (iii) consultants and other independent advisors who provide services to the Corporation (or any Parent
or Subsidiary). 
  
 B. The Plan Administrator shall have full
authority to determine which eligible persons are to receive option grants under the Plan, the time or times when such option grants are to be made, the number of shares to be covered by each such grant, the status of the granted option as either an
Incentive Option or a Non-Statutory Option, the time or times at which each option is to become exercisable, the vesting schedule (if any) applicable to the option shares and the maximum term for which the option is to remain outstanding.

  
 IV. STOCK SUBJECT TO THE PLAN 
  
 A. The stock issuable under the Plan shall be shares of authorized but
unissued or reacquired Class B Common Stock and Class C Common Stock. The maximum number of all shares of Common Stock of the Company which may be issued over the term of the Plan shall not exceed 24,643,000 shares (which has been adjusted for the
Company’s 60 for 1 stock split as of December 31, 2000) and the maximum number of shares of Class B Common Stock and Class C Common Stock which may be issued over the term of the Plan shall not exceed 18,500,000 shares and 6,143,000 shares,
respectively. The share reserve shall automatically increase from time to time so that the sum of (i) the Common Stock subject to outstanding options under the Plan and (ii) the total number of shares of Common Stock outstanding is at all times
equal to fifteen percent (15%) (or such other percentage as is then mandated by the FCC) of the total outstanding securities of the Corporation. Such adjustments are necessary in order to maintain the Corporation’s status as a Small Business.

  
 B. Shares of Common Stock subject to outstanding options shall
be available for subsequent issuance under the Plan to the extent (i) the options expire or terminate for any reason prior to exercise in full or (ii) the options are cancelled in accordance with the cancellation-regrant provisions of Article Two.
All shares of Common Stock issued under the Plan, whether or not those shares are subsequently repurchased by the Corporation pursuant to its repurchase rights under the Plan, shall reduce on a share-for-share basis the number of shares of the
related class of Common Stock available for subsequent issuance under the Plan. 
  
 C. Should any change be made to a class of Common Stock by reason of any stock split, stock dividend, recapitalization, combination of shares, exchange of shares or other change affecting the outstanding shares of
such class as a class without the Corporation’s receipt of consideration, appropriate adjustments shall be made to (i) the maximum number and/or classes of securities issuable under the Plan and (ii) the number and/or classes of securities and
the exercise price per share in effect under each outstanding option in order to prevent the dilution or enlargement of benefits thereunder. The adjustments determined by the Plan Administrator shall be final, binding and conclusive. In no event
shall any such adjustments be made in connection with the conversion of one or more outstanding shares of the Corporation’s preferred stock into shares of any class of Common Stock. 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 2 

 ARTICLE TWO 
  
 OPTION GRANT PROGRAM  
  

I. OPTION TERMS 
  
 Each option shall be evidenced by one or more documents in the form approved by the Plan Administrator, including without limitation the current form of
the “Notice of Grant of Stock Option” attached hereto as Appendix B, together with the exhibits attached thereto; provided, however, that each such document shall comply with the terms specified below. Each document evidencing an Incentive
Option shall, in addition, be subject to the provisions of the Plan applicable to such options. 
  
 A. Exercise Price. 
  
 1. The exercise price per share shall be fixed by the Plan Administrator and may be less than, equal to or greater than the Fair Market Value per share
of the related class of Common Stock on the option grant date. 
  
 2. The exercise price shall become immediately due upon exercise of the option and shall, subject to the provisions of Section I of Article Three and the documents evidencing the option, be payable in cash or check made payable to the
Corporation. Should the related class of Common Stock be registered under Section 12(g) of the 1934 Act at the time the option is exercised, then the exercise price may also be paid as follows: 
  
 (i) in shares of such Common Stock held for the requisite
period necessary to avoid a charge to the Corporation’ s earnings for financial reporting purposes and valued at Fair Market Value on the Exercise Date, or 
  
 (ii) to the extent the option is exercised for vested shares, through a special sale and remittance
procedure pursuant to which the Optionee shall concurrently provide irrevocable written instructions (A) to a Corporation designated brokerage firm to effect the immediate sale of the purchased shares and remit to the Corporation, out of the sale
proceeds available on the settlement date, sufficient funds to cover the aggregate exercise price payable for the purchased shares plus all applicable federal, state and local income and employment taxes required to be withheld by the Corporation by
reason of such exercise and (B) to the Corporation to deliver the certificates for the purchased shares directly to such brokerage firm in order to complete the sale. 
  
 Except to the extent such sale and remittance procedure is utilized, payment of the exercise price for the purchased shares
must be made on the Exercise Date. The exercise price of an option may also be paid by the Optionee electing to use any outstanding amounts credited to the Optionee under the Corporation’s 1999 deferred compensation plan. 
  
 B. Exercise and Term of Options. Each option shall be
exercisable at such time or times, during such period and for such number of shares as shall be determined by the 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 3 

 Plan Administrator and as set forth in the documents evidencing the option. However, no option shall have a term in
excess of fifteen (15) years measured from the option grant date. 
  
 C. Effect of Termination of Service. 
  
 1. The following provisions shall govern the exercise of any options held by the Optionee at the time of cessation of Service or death: 
  
 (i) Any option outstanding at the time of the Optionee’s cessation of Service for any reason shall remain exercisable for such
period of time thereafter as shall be determined by the Plan Administrator and set forth in the documents evidencing the option, but no such option shall be exercisable after the expiration of the option term. 
  
 (ii) Any option exercisable in whole or in part by the
Optionee at the time of death may be exercised subsequently by the personal representative of the Optionee’s estate or by the person or persons to whom the option is transferred pursuant to the Optionee’s will or in accordance with the
laws of descent and distribution. 
  
 (iii)
During the applicable post-Service exercise period, the option may not be exercised in the aggregate for more than the number of vested shares for which the option is exercisable on the date of the Optionee’s cessation of Service. Upon the
expiration of the applicable exercise period or (if earlier) upon the expiration of the option term, the option shall terminate and cease to be outstanding for any vested shares for which the option has not been exercised. However, the option shall,
immediately upon the Optionee’s cessation of Service, terminate and cease to be outstanding to the extent the option is not otherwise at that time exercisable for vested shares. 
  
 (iv) Should the Optionee’s Service be terminated for Misconduct, then all outstanding options held by
the Optionee shall terminate immediately and cease to be outstanding. 
  
 (v) In the event of an Involuntary Termination following a Corporate Transaction, the provisions of Section III of this Article Two shall govern the period for which the outstanding options are to remain exercisable
following the Optionee’s cessation of Service and shall supersede any provisions to the contrary in this section. 
  
 2. The Plan Administrator shall have the discretion, exercisable either at the time an option is granted or at any time while the option remains
outstanding, to: 
  
 (i) extend the period of
time for which the option is to remain exercisable following Optionee’s cessation of Service from the limited period otherwise in effect for that option to such greater period of time as the Plan Administrator shall deem appropriate, but in no
event beyond the expiration of the option term, and/or 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 4 

 (ii) permit the option to be exercised, during the applicable post-Service exercise
period, not only with respect to the number of vested shares of the class of Common Stock for which such option is exercisable at the time of the Optionee’s cessation of Service, but also with respect to one or more additional installments in
which the Optionee would have vested under the option had the Optionee continued in Service. 
  
 D. Stockholder Rights. The holder of an option shall have no stockholder rights with respect to the shares subject to the option until such person shall have exercised the option, paid the exercise price
and become a holder of record of the purchased shares. If any purchased shares are held as a result of the exercise of any options granted under the Plan, then such purchased shares and the holder thereof shall be subject to, and comply with, the
Stockholders Agreement. 
  
 E. Unvested Shares. The
Plan Administrator shall have the discretion to grant options which are exercisable for unvested shares of Common Stock. Should the Optionee cease Service while holding such unvested shares, the Corporation shall have the right to repurchase, at the
exercise price paid per share, all or, at the discretion of the Corporation and with the consent of the Optionee, any of those unvested shares. The terms upon which such repurchase right shall be exercisable (including the period and procedure for
exercise and the appropriate vesting schedule for the purchased shares) shall be established by the Plan Administrator and set forth in the document evidencing such repurchase right. 
  
 F. First Refusal Rights. Until such time as a class of Common Stock is first registered under Section 12(g) of
the 1934 Act, and subject to the provisions of the Stockholders Agreement, the Corporation shall have the right of first refusal with respect to any proposed disposition by the Optionee (or any successor in interest) of any shares of such class of
Common Stock issued under the Plan. Such right of first refusal shall be exercisable in accordance with the terms established by the Plan Administrator and set forth in the document evidencing such right. 
  
 G. Limited Transferability of Options. During the lifetime of
the Optionee, the option shall be exercisable only by the Optionee and shall not be assignable or transferable other than by will or by the laws of descent and distribution following the Optionee’s death. However, a Non-Statutory Option may be
assigned in whole or in part during Optionee’s lifetime in accordance with the terms of a Qualified Domestic Relations Order. The assigned portion may only be exercised by the person or persons who acquire a proprietary interest in the option
pursuant to such Qualified Domestic Relations Order. The terms applicable to the assigned option (or portion thereof) shall be the same as those in effect for the option immediately prior to such assignment and shall be set forth in such documents
issued to the assignee as the Plan Administrator may deem appropriate. In addition, Non-Statutory Options may also be assigned in accordance with such other terms and conditions as the Plan Administrator may deem appropriate at the time of the
option grant. 
  
 Notwithstanding anything in the Plan to the
contrary, to the extent specifically approved by the Plan Administrator, an option may be transferred by an Optionee, without consideration, to his or her immediate family members or related family trusts, or similar entities affiliated with such
Optionee, subject to such terms and conditions as the Plan Administrator may establish. 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 5 

 H. Trust Options. The Plan Administrator, in its sole discretion, may from time to time
grant options which shall be held in trust by the Optionee. The terms applicable to such option grants shall be set forth in the documents issued to the Optionee as trustee at the time of the option grant. 
  
 I. Withholding. The Corporation’s obligation to deliver
shares of Common Stock upon the exercise of any options granted under the Plan shall be subject to the satisfaction of all applicable federal, state and local income and employment tax withholding requirements. 
  
 II. INCENTIVE OPTIONS 
  
 The terms specified below shall be applicable to all Incentive Options.
Except as modified by the provisions of this Section II, all the provisions of the Plan shall be applicable to Incentive Options. Options which are specifically designated as Non-Statutory Options shall not be subject to the terms of this Section
II. 
  
 A. Eligibility. Incentive Options may only
be granted to Employees. 
  
 B. Exercise Price. The
exercise price per share shall not be less than one hundred percent (100%) of the Fair Market Value per share of the related class of Common Stock on the option grant date. 
  
 C. Dollar Limitation. The aggregate Fair Market Value of the shares of all classes of Common Stock (determined
as of the respective date or dates of grant) for which one or more options granted to any Employee under the Plan (or any other option plan of the Corporation or any Parent or Subsidiary) may for the first time become exercisable as Incentive
Options during any one (1) calendar year shall not exceed the sum of One Hundred Thousand Dollars ($100,000). To the extent the Employee holds two (2) or more such options which become exercisable for the first time in the same calendar year, the
foregoing limitation on the exercisability of such options as Incentive Options shall be applied on the basis of the order in which such options are granted. 
  
 D. 10% Stockholder. If any Employee to whom an Incentive Option is granted is a 10% Stockholder, then the exercise price per share shall not
be less than one hundred ten percent (110%) of the Fair Market Value per share of the related class of Common Stock on the option grant date and the option term shall not exceed five (5) years measured from the option grant date. 
  
 III. CORPORATE TRANSACTION 
  
 A. In the event of any Corporate Transaction, each outstanding option shall
automatically accelerate so that each such option shall, immediately prior to the effective date of the Corporate Transaction, become fully exercisable for all of the shares of the related class of Common Stock at the time subject to such option and
may be exercised for any or all of those shares as fully-vested shares of such class of Common Stock. 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 6 

 B. All outstanding repurchase rights shall also terminate automatically, and the shares of Common Stock
subject to those terminated rights shall immediately vest in full, in the event of any Corporate Transaction. 
  
 C. Immediately following the consummation of the Corporate Transaction, all outstanding options shall terminate and cease to be outstanding, except to the
extent assumed by the successor corporation (or parent thereof). 
  
 D. Each option which is assumed in connection with a Corporate Transaction shall be appropriately adjusted, immediately after such Corporate Transaction, to apply to the number and class of securities which would have been issuable to the
Optionee in consummation of such Corporate Transaction, had the option been exercised immediately prior to such Corporate Transaction. Appropriate adjustments shall also be made to (i) the number and class of securities available for issuance under
the Plan following the consummation of such Corporate Transaction and (ii) the exercise price payable per share under each outstanding option, provided the aggregate exercise price payable for such securities shall remain the same. 
  
 E. In the event the Optionee’s Service should terminate by reason of an
Involuntary Termination within eighteen (18) months following the effective date of such Corporate Transaction, any options shall remain exercisable for fully-vested shares until the earlier of (i) the expiration of the option term or (ii) the
expiration of the one (1) year period measured from the effective date of the Involuntary Termination. 
  
 F. The Plan Administrator shall have the discretion to grant options with terms different from those described in this Section III. 
  
 G. The portion of any Incentive Option accelerated in connection with a
Corporate Transaction shall remain exercisable as an Incentive Option only to the extent the applicable One Hundred Thousand Dollar limitation is not exceeded. To the extent such dollar limitation is exceeded, the accelerated portion of such option
shall be exercisable as a Non-Statutory Option under the federal tax laws. 
  
 H. The grant of options under the Plan shall in no way affect the right of the Corporation to adjust, reclassify, reorganize or otherwise change its capital or business structure or to merge, consolidate, dissolve,
liquidate or sell or transfer all or any part of its business or assets. 
  
 IV. REPRICING, CANCELLATION AND REGRANT OF OPTIONS 
  
 The Plan Administrator shall have the authority to effect, at any time and from time to time, with the consent of the affected option holders, the re-pricing or cancellation of any or all outstanding options under the
Plan and, if repriced or canceled, to grant in substitution new options covering the same or different number of shares of the same class of Common Stock, in either case, with an exercise price per share as determined by the Plan Administrator, in
its discretion. 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 7 

 ARTICLE THREE 
  
 MISCELLANEOUS 
  
 I. [RESERVED] 
  
 II. EFFECTIVE DATE AND TERM OF PLAN 
  
 A. This amendment and restatement of the Plan shall become effective when adopted by the Board, but no options that have been granted for Class C Common
Stock pursuant to the terms of this amendment and restatement of the Plan may be exercised until this amendment and restatement of the Plan is approved by the Corporation’s stockholders. If such stockholder approval is not obtained within
twelve (12) months after the date of the Board’s adoption of this amendment and restatement of the Plan, then all options that have been previously granted for Class C Common Stock pursuant to the terms of this amendment and restatement of the
Plan shall terminate and cease to be outstanding and no further options shall be granted pursuant to the terms of this amendment and restatement of the Plan; provided, however, that all options previously granted under the Plan (other than those for
Class C Common Stock) shall remain in full force and effect and not be terminated or cease as a result of such approval not being obtained. Subject to such limitation, the Plan Administrator may grant options under the Plan at any time after the
effective date of the Plan and before the date fixed herein for termination of the Plan. 
  
 B. The Plan shall terminate upon the earliest of (i) the expiration of ten (10) years following the date the Plan was adopted by the Board, (ii) the date on which all shares available for issuance under the Plan shall
have been issued or (iii) the termination of all outstanding options in connection with a Corporate Transaction. Upon such Plan termination, all options and unvested stock issuances outstanding under the Plan shall continue to have full force and
effect in accordance with the provisions of the documents evidencing such options or issuances. 
  
 III. AMENDMENT OF THE PLAN 
  
 A. The Board shall have complete and exclusive power and authority to amend or modify the Plan in any or all respects. However, no such amendment or
modification shall, without the consent of the Optionees, adversely affect their rights and obligations under their outstanding options. In addition, the Board shall not, without the approval of the Corporation’ s stockholders, (i) increase the
maximum number of shares issuable under the Plan, except for permissible adjustments in the event of certain changes in the Corporation’s capitalization, (ii) materially modify the eligibility requirements for Plan participation or (iii)
materially increase the benefits accruing to Plan participants. 
  
 B. Options may be granted under the Plan to purchase shares of any class of Common Stock in excess of the number of shares then available for issuance under the Plan, provided any such options actually granted may not be exercised until
there is obtained stockholder approval of an amendment sufficiently increasing the number of shares of such class of Common Stock available for issuance under the Plan. If such stockholder approval is not 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 8 

 obtained within eighteen (18) months after the date the excess grants are first made, then any options granted on the
basis of such excess shares shall terminate and cease to be outstanding. 
  
 IV. USE OF PROCEEDS 
  
 Any
cash proceeds received by the Corporation from the sale of shares of Common Stock under the Plan shall be used for general corporate purposes. 
  
 V. REGULATORY APPROVALS 
  
 The implementation of the Plan, the granting of any option under the Plan and the issuance of any shares of Common Stock upon the exercise of any option
shall be subject to the Corporation’s procurement of all approvals and permits required by regulatory authorities having jurisdiction over the Plan, the options granted under it and the shares of Common Stock issued pursuant to it. 

 
 VI. NO EMPLOYMENT OR SERVICE RIGHTS 
  
 Nothing in the Plan shall confer upon the Optionee any right to continue in
Service for any period of specific duration or interfere with or otherwise restrict in any way the rights of the Corporation (or any Parent or Subsidiary employing or retaining the Optionee) or of the Optionee, which rights are hereby expressly
reserved by each, to terminate the Optionee’s Service at any time for any reason, with or without cause. 
  

 Amended & Restated 1995 Stock Option Plan as of 12/16/03 – Page 9 

 APPENDIX A  
  
 The following definitions shall be in effect under the Plan: 
  
 A. Board shall mean the Corporation’s Board of Directors. 
  
 B. Class B Common Stock shall mean the Corporation’s Class
B common stock. 
  
 C. Class C Common Stock shall
mean the Corporation’s Class C common stock. 
  
 D.
Code shall mean the Internal Revenue Code of 1986, as amended. 
  
 E. Committee shall mean a committee of two (2) or more Board members appointed by the Board to exercise one or more administrative functions under the Plan. 
  
 F. Common Stock shall mean the Corporation’s Class B
Common Stock and Class C Common Stock. 
  
 G. Corporate
Transaction shall mean either of the following stockholder-approved transactions to which the Corporation is a party: 
  
 (i) a merger or consolidation in which securities possessing more than fifty percent (50%) of the total combined voting power of the Corporation’s
outstanding securities are transferred to a person or persons different from the persons holding those securities immediately prior to such transaction, or 
  
 (ii) the sale, transfer or other disposition of all or substantially all of the Corporation’s assets in complete liquidation or dissolution of the
Corporation. 
  
 H. Corporation shall mean MetroPCS,
Inc., a Delaware corporation. 
  
 I. Domestic Relations
Order shall mean any judgment, decree or order (including approval of a property settlement agreement) which provides or otherwise conveys, pursuant to applicable state domestic relations laws (including community property laws), marital
property rights to any spouse or former spouse of the Optionee. 
  
 J. Employee shall mean an individual who is in the employ of the Corporation (or any Parent or Subsidiary), subject to the control and direction of the employer entity as to both the work to be performed and the manner and
method of performance. 
  
 K. Exercise Date shall
mean the date on which the Corporation shall have received written notice of the option exercise. 
  
 L. Fair Market Value per share of any class of Common Stock on any relevant date shall be determined in accordance with the following
provisions: 
  
 (i) If such class of Common Stock is at the time
traded on the Nasdaq National Market, then the Fair Market Value shall be the closing selling price per share of such class of Common Stock on the date in question, as such price is reported by the National 
  

 A-1 

 Association Securities Dealers on the Nasdaq National Market or any successor system. If there is no closing selling
price for such class of Common Stock on the date in question, then the Fair Market Value shall be the closing selling price on the last preceding date for which such quotation exists. 
  
 (ii) If such class of Common Stock is at the time listed on any Stock Exchange, then the Fair Market Value shall be the
closing selling price per share of such class of Common Stock on the date in question on the Stock Exchange as determined by the Plan Administrator to be the primary market for such class of Common Stock, as such price is officially quoted in the
composite tape of transactions on such exchange. If there is no closing selling price for such class of Common Stock on the date in question, then the Fair Market Value shall be the closing selling price on the last preceding date for which such
quotation exists. 
  
 (iii) If such class of Common Stock is at
the time neither listed on any Stock Exchange nor traded on the Nasdaq National Market, then the Fair Market Value shall be determined by the Plan Administrator after taking into account such factors as the Plan Administrator shall deem appropriate.

  
 M. FCC shall mean the Federal Communications
Commission. 
  
 N. Incentive Option shall mean an
option which satisfies the requirements of Code Section 422. 
  
 O. Involuntary Termination shall mean the termination of the Service of any individual which occurs by reason of: 
  
 (i) such individual’s involuntary dismissal or discharge by the Corporation for reasons other than Misconduct, or 
  
 (ii) such individual’s voluntary resignation following (A) a change in
his or her position with the Corporation which materially reduces his or her level of responsibility, (B) a reduction in his or her level of compensation (including base salary, fringe benefits and participation in corporate-performance based bonus
or incentive programs) by more than fifteen percent (15%) or (C) a relocation of such individual’s place of employment by more than fifty (50) miles, provided and only if such change, reduction or relocation is effected without the
individual’s consent. 
  
 P. Misconduct shall
mean the commission of any act of fraud, embezzlement or dishonesty by the Optionee, any unauthorized use or disclosure by such person of confidential information or trade secrets of the Corporation (or any Parent or Subsidiary), or any other
intentional misconduct by such person adversely affecting the business or affairs of the Corporation (or any Parent or Subsidiary) in a material manner. The foregoing definition shall not be deemed to be inclusive of all the acts or omissions which
the Corporation (or any Parent or Subsidiary) may consider as grounds for the dismissal or discharge of any Optionee or other person in the Service of the Corporation (or any Parent or Subsidiary). 
  
 Q. 1934 Act shall mean the Securities Exchange Act of 1934, as
amended. 
  

 A-2 

 R. Non-Statutory Option shall mean an option not intended to satisfy the requirements of
Code Section 422. 
  
 S. Optionee shall mean any
person to whom an option is granted under the Plan. 
  
 T.
Parent shall mean any corporation (other than the Corporation) in an unbroken chain of corporations ending with the Corporation, provided each corporation in the unbroken chain (other than the Corporation) owns, at the time of the
determination, stock possessing fifty percent (50%) or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. 
  
 U. Permanent Disability shall mean the inability of the Optionee to engage in any substantial gainful activity
by reason of any medically determinable physical or mental impairment expected to result in death or to be of continuous duration of twelve (12) months or more. 
  

V. Plan shall mean the Amended & Restated 1995 Stock Option Plan of MetroPCS, Inc., as set forth in this document, and as the same
may be further amended or supplemented from time to time. 
  
 W.
Plan Administrator shall mean either the Board or the Committee, to the extent the Committee is at the time responsible for the administration of the Plan. 
  
 X. Qualified Domestic Relations Order shall mean a Domestic Relations Order which substantially complies with
the requirements of Code Section 414(p). The Plan Administrator shall have the sole discretion to determine whether a Domestic Relations Order is a Qualified Domestic Relations Order. 
  
 Y. Service shall mean the provision of services to the Corporation (or any Parent or Subsidiary) by a person
in the capacity of an Employee, a non-employee member of the board of directors or a consultant or independent advisor, except to the extent otherwise specifically provided in the documents evidencing the option grant. 
  
 Z. Stockholders Agreement shall mean the Amended and Restated
Stockholders Agreement dated as of July 17, 2000, as amended by Amendment No. 1 thereto dated as of November 13, 2000, and as further as amended by Amendment No. 2 thereto dated as of January 4, 2001, by and among the Company, the Class A
Stockholders (consisting of Roger D. Linquist and C. Boyden Gray), the Class B Stockholders listed on Schedule 1 thereto, the Class C Stockholders listed on Schedule 2 thereto, the Series C Preferred Stockholders listed on Schedule 3 thereto, and
the Series D Preferred Stockholders listed on Schedule 4 thereto, as the same may be further amended or supplemented from time to time. 
  
 AA. Small Business shall mean a small business, as such term is defined under FCC rules and regulations. 
  
 BB. Stock Exchange shall mean either the American Stock
Exchange or the New York Stock Exchange. 
  

 A-3 

 CC. Subsidiary shall mean any corporation (other than the Corporation) in an unbroken chain
of corporations beginning with the Corporation, provided each corporation (other than the last corporation) in the unbroken chain owns, at the time of the determination, stock possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock in one of the other corporations in such chain. 
  
 DD. 10% Stockholder shall mean the owner of stock (as determined under Code Section 424(d)) possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Corporation (or any Parent or
Subsidiary). 
  

 A-4 

 APPENDIX B  
  
 Notice of Grant of Stock Option 
  
 [Begins on next page] 
  

 B-1AMNDMT #4 TO CONTRACT CLINICAL RESEARCH AGMT WITH CROMEDICA GLOBAL, 8/18/2003

 EXHIBIT 10.45 
  
 AMENDMENT #4 
  
 Protocol # V1T—02-08961X 
  
 PRA Project ID #1600 
  
 THIS AMENDMENT #4 (“Amendment #4”), dated as of the 18th day of August, 2003 (the “Effective Date”), by and between CroMedica Global, Inc. (“CroMedica”) and ISTA Pharmaceuticals (formerly known
as Advanced Corneal Systems, Inc. (hereinafter “Sponsor”). 
  
 W I T N E S S E T H: 
  
 WHEREAS,
under the terms of a certain Contract for Clinical Research Agreement (the “Agreement”), dated the 8th
day of September, 1998 as amended by Amendment #1, dated October 11, 2000, Amendment #2, dated February 21, 2001, and Amendment #3, dated December 5, 2001 by and between the parties, Sponsor agreed to retain CroMedica, and CroMedica agreed to be
retained by Sponsor, to perform the Services as more particularly described in the Agreement pursuant to the terms of the Agreement; and 
  
 WHEREAS, the parties hereto have entered into certain additional agreements with respect to modification of the Agreement, and which they desire to
memorialize in this Amendment #4; 
  
 NOW, THEREFORE, in
consideration of the premises and of the following mutual promises, covenants and conditions hereinafter set forth, the parties hereto agree as follows: 
  
 1. Change in Name of CroMedica. The parties acknowledge that CroMedica Global Inc. is now doing business as Pharmaceutical Research Associates,
Inc. (“PRA”), and that this change of name does not alter the terms and conditions set forth in the Agreement. All references to CroMedica in the Agreement shall now be construed to mean references to PRA. The terms of the Agreement are
only modified to the extent of the amendments set forth below. 
  
 2. Payment and Performance Schedule. The Services to be provided by PRA pursuant to the Agreement are hereby amended to reflect that Sponsor has assumed responsibility for monitoring certain investigative sites, and to reflect
PRA’s monitoring visits and safety reporting through December 2002. These changes to the Services are described in the revised Attachment 2, which is attached hereto and incorporated herein by reference. 
  
 3. Ratification of Balance of Agreement. In all other respects, the
terms of the Agreement are hereby ratified and affirmed by each of the parties hereto. 
  
 4. Headings. The headings in this Amendment #4 are for convenience of reference only and shall not affect its interpretation. 
  

 Page 1 of 15 

 IN WITNESS WHEREOF, the parties hereto, each by a duly authorized representative, have executed this
Amendment #4 as of the date first written above. 
  

									
	 PHARMACEUTICAL RESEARCH
 ASSOCIATES, INC.
	 	 	 	ISTA PHARMACEUTICALS
					
	 By:
	 	 /s/ Greg A. Johnson
	 	 	 	By:	 	 /s/ Risa L. Grillone

	 	 	
	 	 	 	 	 	

	 	 	 Greg A. Johnson
	 	 	 	 	 	 Authorized Signature

	 	 	 	 	 	 	 	 	 
	 Title: Vice President, Operations
	 	 	 	 Title: Vice President, Clinical Research

	 Date: 22 Aug 2003
	 	 	 	 Date: 16 Sept 03

  

 Page 2 of 15 

 REVISED ATTACHMENT 2 
 AMENDED PROJECT SPECIFICATIONS 
  

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	 	 	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	 Up front (20%)
	  	 	  	563,525.00	  	 	  	563,525.00	  	 	  	 	  	563,525.00	  	 	 	 	563,525.00
	Australia Regulatory Submission	  	10,000.00	  	10,000.00	  	 	  	10,000.00	  	 	  	 	  	10,000.00	  	 	 	 	10,000.00
	 CRF Finalization
	  	8,580.00	  	8,580.00	  	 	  	8,580.00	  	 	  	 	  	8,580.00	  	 	 	 	8,580.00
	 Site Recruitment:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	200.00	  	2,400.00	  	 	  	2,400.00	  	 	  	 	  	2,400.00	  	(2,400.00	)	 	0.00
	 U.S.
	  	240.00	  	2,880.00	  	 	  	2,880.00	  	 	  	 	  	2,880.00	  	(2,880.00	)	 	0.00
	 Australia
	  	240.00	  	2,400.00	  	 	  	2,400.00	  	 	  	 	  	2,400.00	  	(2,400.00	)	 	0.00
	 AMENDMENT #4 ADJUSTMENT: Revised based on actual number of site identifications performed:
 5 Canadian, 12 US, 8 Australian.
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	200.00	  	 	  	 	  	 	  	 	  	 	  	 	  	1,000.00	 	 	1,000.00
	 U.S.
	  	240.00	  	 	  	 	  	 	  	 	  	 	  	 	  	2,880.00	 	 	2,880.00
	 Australia
	  	240.00	  	 	  	 	  	 	  	 	  	 	  	 	  	1,920.00	 	 	1,920.00
	 Initiation Visits:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	600.00	  	7,200.00	  	 	  	7,200.00	  	 	  	 	  	7,200.00	  	(7,200.00	)	 	0.00
	 U.S.
	  	720.00	  	18,720.00	  	 	  	18,720.00	  	 	  	 	  	18,720.00	  	(18,720.00	)	 	0.00
	 Australia
	  	1,080.00	  	10,800.00	  	 	  	10,800.00	  	 	  	 	  	10,800.00	  	(10,800.00	)	 	0.00
	AMENDMENT #4 ADJUSTMENT: Revised based on actual number of initiations performed: 9 Canadian, 31 US, 8 Australian.	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	600.00	  	 	  	 	  	 	  	 	  	 	  	 	  	5,400.00	 	 	5,400.00
	 U.S.
	  	720.00	  	 	  	 	  	 	  	 	  	 	  	 	  	22,320.00	 	 	22,320.00
	 Australia
	  	1,080.00	  	 	  	 	  	 	  	 	  	 	  	 	  	8,640.00	 	 	8,640.00

  

 Page 3 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	 	 	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	 Interim Visits:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	1,200.00	  	183,600.00	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 U.S.
	  	1,440.00	  	1,156,680.00	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Australia
	  	1,280.00	  	124,800.00	  	 	  	124,800.00	  	 	  	 	  	 	  	 	 	 	 
	 AMENDMENT 2 ADD:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	7 additional monitoring visits per site related to 3 interim analyses and resolution of clinical review queries not originally contracted:	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 11 sites x 7 visits
	  	 	  	 	  	92,400.00	  	276,000.00	  	 	  	 	  	 	  	 	 	 	 
	 AMENDMENT #2
 ADJUSTMENT: Per visit rate
adjusted to $1800/visit for visits occurring post-March, 2001 due to increased patient population, extensive CRF changes, increased on site effort
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	   58 x $1,200 =     69,600
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	   38 x $1,800 =     68,400
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 134 x $1,800 =   241,200
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Total                          $379,200
	  	 	  	 	  	 	  	 	  	22,800.00	  	80,400.00	  	379,200.00	  	(379,200.00	)	 	0.00
	 U.S.
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 58 sites x 7 visits
	  	 	  	 	  	584,640.00	  	1,741,320.00	  	 	  	 	  	 	  	 	 	 	 
	 AMENDMENT #2
 ADJUSTMENT: Per visit rate
adjusted to $2160/visit for visits occurring post-March, 2001 due to increased patient population, extensive CRF changes, increased on site effort
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 608 x $1,440 =     875,520
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 

  

 Page 4 of 15 

																				
	 	  	Unit Cost

	  	 Original
 Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	 	 	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	 212 x $2,160 =      457,920
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 389 x $2,160 =      840,240
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Total                          $2,173,680
	  	 	  	 	  	 	  	 	  	152,640.00	  	279,720.00	  	2,173,680.00	  	(2,173,680.00	)	 	0.00
	 AMENDMENT 3 ADD:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	North America: 2.25 visits per site to take total visits per site to 22 over life of study Australia: 5 visits per site to take total visits per site to 16 over life of study	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 11 sites x 2.25 visits
	  	1,800.00	  	 	  	 	  	 	  	 	  	44,550.00	  	44,550.00	  	(44,550.00	)	 	0.00
	 U.S.
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 58 sites x 2.25 visits
	  	2,160.00	  	 	  	 	  	 	  	 	  	281,880.00	  	281,880.00	  	(281,880.00	)	 	0.00
	 Australia
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 9 sites x 5 visits
	  	1,280.00	  	 	  	 	  	 	  	 	  	57,600.00	  	182,400.00	  	(182,400.00	)	 	0.00

  

 Page 5 of 15 

																			
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	 AMENDMENT #4
 ADJUSTMENT: North American
interim per visit rate increased by 4 hours/visit for visits occurring between Sept 11, 2001 and Nov 30, 2002 due to increased travel time related to airport security measures.
  
 Effective Dec 1, 2002 CRAs reallocated to reduce travel time to pre-Sept 11, 2001 allowance of 4 hours/visit, with ISTA assuming
responsibility for visits to sites requiring additional travel. PRA will monitor 9 Canadian sites, 8 US sites, and 5 Australian sites to June 2003. Per visit rate increased to include 1.5 hours per visit as discussed with Lisa Grillone December 9,
2002, to reflect additional in-house effort by CRAs for telephone query resolution in order to accommodate less frequent visit schedule.
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	Canada: 92 visits pre-Sept 11/01 (58 @ $1200, 34 @ $1800); 29 visits post-Sept 11/01 to Dec 31/02 @ $2100; 11 - one day visits projected to Jun 30, 2003 @$1912/visit based on assumption
that CRA allocations can be revised to reduce travel time to four hours/visit.	  	1,200.00
1,800.00
2,100.00  
  
 1,912.00
	  	 	  	 	  	 	  	 	  	 	  	 	  	69,600.00
61,200.00
60,900.00  
  
 21,032.00
	  	69,600.00
61,200.00
60,900.00  
  
 21,032.00

  

 Page 6 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	 	 	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	Revised
Study Total
($US)

	 	  	  	  	 	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	Canada: 2 day visits from Jan 1, 2003 to June 30, 2003: 7 @ $2,625 per visit	  	2,625.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	18,375.00	  	18,375.00
	 U.S. 754 visits pre-Sept
 11/01 (608 @ $1440, 146
@ $2160); 207 visits post-Sept 11/01 to Dec 31/02 @ $2520; 11 - one day visits projected to June 30, 2003 @ $2300/visit based on assumption that CRA allocations can be revised to reduce travel time to four hours/visit.
	  	1,440.00
2,160.00
2,520.00  
 2,300.00
	  	 	  	 	 	 	 	  	 	  	 	  	 	  	875,520.00
315,360.00
521,640.00  
 25,300.00
	  	875,520.00
315,360.00
521,640.00  
 25,300.00

	U.S.: 2 day visits from Jan 1, 2003 to June 30, 2003: 1 @ $3,150 per visit	  	3,150.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	3,150.00	  	3,150.00
	Australia: 62 visits to Sept 30/02 (not including unmasked monitoring visits); 8 more to Apr 30, 2003; Estimated remaining visits: 3 total to be done May and June 2003.	  	1,280.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	93,440.00	  	93,440.00
	REMOVE: Unmasked Visits North America:	  	 	  	 	  	 	 	 	 	  	 	  	 	  	 	  	 	  	 
	 Canadian
	  	900.00	  	10,800.00	  	(10,800.00	)	 	0.00	  	 	  	 	  	0.00	  	 	  	 
	 U.S.
	  	1,080.00	  	68,040.00	  	(68,040.00	)	 	0.00	  	 	  	 	  	0.00	  	 	  	 

  

 Page 7 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	 	 	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	AMENDMENT 3 Umasked Visits Australia - initial 6 visits for 6 sites performed and billed at regular monitoring rate for Australia (same rate of $1280). ADD Add’l 6
visits for 6 sites requested by ISTA	  	1,280.00	  	 	  	 	  	 	  	7,680.00	  	 	  	7,680.00	  	 	 	 	7,680.00
	 AMENDMENT 3
 ADD: Staff Training
Australia - Unmasked Monitoring Procedures:
	  	1,000.00	  	 	  	 	  	 	  	1,000.00	  	 	  	1,000.00	  	 	 	 	1,000.00
	Close Out Visits:	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	 Canadian
	  	900.00	  	10,800.00	  	 	  	10,800.00	  	 	  	 	  	10,800.00	  	(10,800.00	)	 	0.00
	 U.S.
	  	1,080.00	  	81,000.00	  	 	  	81,000.00	  	 	  	 	  	81,000.00	  	(81,000.00	)	 	0.00
	 Australia
	  	960.00	  	9,600.00	  	 	  	9,600.00	  	 	  	 	  	9,600.00	  	(9,600.00	)	 	0.00
	 AMENDMENT #4
 ADJUSTMENT: Close-out per
visit rate increased by 4 hours/visit for visits occurring between Sept 11, 2001 and Nov 30, 2002 due to increased travel time related to airport security measures. Number of units adjusted to reflect actual close-outs required.
 Effective Dec 1, 2002 CRAs reallocated to reduce travel time to pre-Sept 11, 2001 allowance of 4 hours/visit, with ISTA assuming responsibility for visits to sites
requiring additional travel. PRA will monitor 9 Canadian sites, 8 US sites, and 5 Australian sites to June 30, 2003.
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 

  

 Page 8 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	 	 	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	Revised
Study Total
($US)

	 	  	  	  	 	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	 Canada: 0 pre-Sept 11/01; 1 post-Sept 11/01 to Nov 30/02 @$1200; 9 remaining to be charged at $900/visit based on assumption that CRA
allocations can be revised to reduce travel time to four hours/visit.
  
 US: 5 pre-Sept 11/01 @ $1080; 6 post-Sept 11/01 to Nov 30/02 @ $1440; 8 remaining to be charged at $1080/visit based on assumption that CRA allocations can be revised to reduce travel time to four hours/visit.
  
 Australia: 3 close-outs to Nov 30/02; 5 remaining.
	  	 	  	 	  	 	 	 	 	  	 	  	 	  	 	  	 	  	 
	 Canadian:
	  	1,200.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	1,200.00	  	1,200.00
	 	  	900.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	8,100.00	  	8,100.00
	 U.S.
	  	1,080.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	5,400.00	  	5,400.00
	 	  	1,440.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	8,640.00	  	8,640.00
	 	  	1,080.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	8,640.00	  	8,640.00
	 Australia
	  	960.00	  	 	  	 	 	 	 	  	 	  	 	  	 	  	7,680.00	  	7,680.00
	 REMOVE: Site Audits
	  	2,500.00	  	125,000.00	  	(125,000.00	)	 	0.00	  	 	  	 	  	0.00	  	 	  	 
	 Australia Investigator Meeting
	  	12,000.00	  	12,000.00	  	 	 	 	12,000.00	  	 	  	 	  	12,000.00	  	 	  	12,000.00
	 Study Training
	  	24,550.00	  	24,550.00	  	 	 	 	24,550.00	  	 	  	 	  	24,550.00	  	 	  	24,550.00
	ADD: Training for Protocol Amendment, new CRFs, rescue data – CRAs and at sites – 2 hours per site.	  	 	  	 	  	 	 	 	 	  	 	  	 	  	 	  	 	  	 

  

 Page 9 of 15 

																			
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	 ($75x 2hr x 11 sites) Canadian
	  	150.00	  	 	  	1,650.00	  	1,650.00	  	 	  	 	  	1,650.00	  	 	  	1,650.00
	 ($90x 2 hr x 58 sites) U.S.
	  	180.00	  	 	  	10,440.00	  	10,440.00	  	 	  	 	  	10,440.00	  	 	  	10,440.00
	 AMENDMENT 4
 ADD: Additional training,
previously invoiced July 1999.
	  	6,300.00	  	 	  	 	  	 	  	 	  	 	  	 	  	6,300.00	  	6,300.00
	 SAE Management
	  	300.00	  	81,600.00	  	 	  	81,600.00	  	 	  	 	  	81,600.00	  	 	  	81,600.00
	 AMENDMENT 2
 ADD: SAE Management Estimate
of 272 additional SAEs representing an overall 80% SAE rate for the study.
	  	500.00	  	 	  	136,000.00	  	136,000.00	  	 	  	 	  	136,000.00	  	 	  	136,000.00
	 AMENDMENT 4
 ADD: SAE Management: 687
additional SAEs processed to April 30, 2003 (1231 total to April 30, 2003, less 544 included up to and including amendment 2) plus 19 projected to occur to end of study (estimated study total = 1250).
	  	500.00	  	 	  	 	  	 	  	 	  	 	  	 	  	353,000.00	  	353,000.00
	 Database Design
	  	13,500.00	  	13,500.00	  	 	  	13,500.00	  	 	  	 	  	13,500.00	  	 	  	13,500.00
	 AMENDMENT 2
 ADD: Additional 50 hours at
$75/hr for creation & distribution of new CRF forms (BCVA & Efficacy)
	  	 	  	 	  	3,750.00	  	3,750.00	  	 	  	 	  	3,750.00	  	 	  	3,750.00
	 Data Entry:
	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 1/3 Data Entered
	  	50,000.00	  	50,000.00	  	 	  	50,000.00	  	 	  	 	  	50,000.00	  	 	  	50,000.00
	 2/3 Data Entered
	  	50,000.00	  	50,000.00	  	 	  	50,000.00	  	 	  	 	  	50,000.00	  	 	  	50,000.00
	 3/3 Data Entered
	  	50,000.00	  	50,000.00	  	 	  	50,000.00	  	 	  	 	  	50,000.00	  	 	  	50,000.00

  

 Page 10 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	 	 	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	 AMENDMENT 2
 ADD: Data Management Services relating to extra visit, all pts, at 18 months Original contract per page value of $4/pg x 8 pgs x 1190 pts. May 15 03: 3,015 pgs in house, expecting 500 more, total 3,515 @ $4
	  	4.00	  	 	  	38,080.00	  	38,080.00	  	 	  	 	  	38,080.00	  	(38,080.00	)	 	 
	AMENDMENT 4: At May 15, 2003, 3,015 pgs inhouse; expecting 500 more for a total of 3,515 pgs @ $4/page	  	4.00	  	 	  	 	  	 	  	 	  	 	  	 	  	14,060.00	 	 	14,060.00
	 AMENDMENT 3
 ADD: Additional Data
Management Services based on 5 add’l pt. Visits x 9 pages x 1190 pts x $10 per page.
 AMENDMENT 4: ADJUST 2003 CRF PAGES EXPECTED: Data
management services for projected 10,500 pages to be received in 2003 (3 patient visits x 5 pages/visit x 700 patients) x $10 per page. May 15/03: Now 3,852 pgs in house. 3,000 more expected total: 6852 @ $10
	  	10.00	  	 	  	 	  	 	  	12,610.00	  	522,890.00	  	535,500.00	  	(466,980.00	)	 	68,520.00
	ADD: Additional Coding Requirements “Other Procedures” performed to date (Nov/01): Clinical Review Dept & Physician : 48 hours x $95/hr plus 2 hrs x $250/hr	  	5,060.00	  	 	  	 	  	 	  	5,060.00	  	 	  	5,060.00	  	 	 	 	5,060.00

  

 Page 11 of 15 

																			
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	Revised
Study Total
($US)

	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	ADD: Clinical Data Review Process: 1 hour per pt x approx. 1013 pts x $95/hour	  	96,235.00	  	 	  	 	  	 	  	96,235.00	  	 	  	96,235.00	  	 	  	96,235.00
	ADD: SAE Page QC Review: 150 hours x $95/hour	  	14,250.00	  	 	  	 	  	 	  	12,825.00	  	1,425.00	  	14,250.00	  	 	  	14,250.00
	 AMENDMENT 4: ADD:
 Scanning support provided April
2002, invoiced previously.
	  	2,352.00	  	 	  	 	  	 	  	 	  	 	  	 	  	2,352.50	  	2,352.50
	AMENDMENT 4: ADD: Out of scope CRF Printing services performed January 2001 - April 2003.	  	7,035.00	  	 	  	 	  	 	  	 	  	 	  	 	  	7,035.00	  	7,035.00
	 AMENDMENT 4: ADD: Additional Clinical Review Queries written by ISTA, processed by CroMedica:
 120 hours x $95/hr.
	  	11,400.00	  	 	  	 	  	 	  	 	  	 	  	 	  	11,400.00	  	11,400.00
	AMENDMENT: 4 ADD: Processing “True Copy” pages: Estimated 5,000 pages will require individual manual check against pages in file and DCFs in file, and data cleaning,
projected to June 30, 2003.	  	Incremental
effort over
normal
processing =
$13.50/page.	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	  	13.50	  	 	  	 	  	 	  	 	  	 	  	 	  	67,500.00	  	67,500.00
	Project Management Fees	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	(per month for 25 months - rate reflects absorption of fees in up front payment)	  	5,566.00	  	139,150.00	  	 	  	139,150.00	  	 	  	 	  	139,150.00	  	 	  	139,150.00
	ADD: 15 add’l months (extended to September, 2002)	  	18,075.00	  	 	  	271,125.00	  	271,125.00	  	 	  	 	  	271,125.00	  	 	  	271,125.00
	AMENDMENT 3 ADD: 39 months	  	10,000.00	  	 	  	 	  	 	  	 	  	390,000.00	  	390,000.00	  	 	  	390,000.00

  

 Page 12 of 15 

																					
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment 4

	 	 	Revised
Study Total
($US)

	 
	 	  	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	 	Amendment
#4

	 
	October, 2002 - March, 2005 and monthly payment to be revisited to establish continued level of effort for Project Management (study extended to December, 2005)	  	10,000.00	  	 	  	 	  	 	  	 	  	 	  	 	  	(370,000.00	)	 	(370,000.00	)
	AMENDMENT 4 REMOVE: Project Management beyond December 2003. ADJUST: Project Management fees for December 2002 to 12,307.69 (based on original agreement with Lisa Grillione of $160,000
for 13 months, Dec 02 to Dec 03)	  	12,307.69	  	 	  	 	  	 	  	 	  	 	  	 	  	12,307.69	 	 	12,307.69	 
	Amendment 4 adj: remove Jan 03 to Dec 03 @ 12,037.69. Should be @ $15,000 per month to July 31/03 as agreed with Lisa Grillione Dec 9 2002 if study wrapped up.	  	12,307.69	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 	 
	Note: It was also agreed that should ISTA opt to close out study in April 2003 instead of December, monthly project management fees of $15,000 will apply from January 1, 2003 to July 31, 2003.
Should the study extend beyond July 31, 2003 additional charges to be determined at that time will apply. Work will not extend beyond July 31, 2003 without a signed change order in place.	  	15,000.00	  	 	  	 	  	 	  	 	  	 	  	 	  	105,000.00	 	 	105,000.00	 

  

 Page 13 of 15 

																				
	 	  	Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	Revised Study
Total ($US)

	  	Adjustment
Amendment
3 Occurring
to Nov. 2001

	  	Adjustment
Amendment 3
Occurring post
Nov. 2001

	  	Revised Study
Total ($US)

	  	Adjustment
Amendment 4

	 	 	Revised Study
Total ($US)

	 	  	  	  	  	Amendment 2

	  	  	  	Amendment #3

	  	 	Amendment #4

	AMENDMENT 3 ADD: Senior Management Services - Dr. Wayne Davis 6 hrs/ wk x 19 weeks to end of 2001 x $250/hour	  	28,500.00	  	 	  	 	  	 	  	28,500.00	  	 	  	28,500.00	  	 	 	 	28,500.00
	Enrollment Tracking:	  	2,519.71	  	120,946.00	  	 	  	120,946.00	  	 	  	 	  	120,946.00	  	 	 	 	120,946.00
	Effective October, 2000 - $2,519.71 per month for 48 months. All work has been completed. Total Invoiced to Mar 31/03: 75,591.30. Balance of $45,354.70 to be invoiced upon execution of Amendment
4	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	 	 	 
	AMENDMENT 4 ADD: Enrollment tracking only for 25 weeks extended enrollment @$655/week.	  	16,375.00	  	 	  	 	  	 	  	 	  	 	  	 	  	16,375.00	 	 	16,375.00
	AMENDMENT 3 ADD: Australia 38 hours to May, 2001 to address Drug & Saline Expiration Issue	  	3,760.00	  	 	  	 	  	 	  	3,760.00	  	 	  	3,760.00	  	 	 	 	3,760.00
	AMENDMENT 4 Add: SAE Hard Copy, based on total estimated SAEs of 1,250. Calculated as: Drug Safety: .08 hrs per SAE plus 16 hours @ US$120/hr for Drug Safety personnel and .08 hrs per SAE
@ US$68/hr for Project Assistant or $16.58 per SAE	  	16.58	  	 	  	 	  	 	  	 	  	 	  	 	  	20,725.00	 	 	20,725.00
	 AMENDMENT 4 Add: 1.5
 hrs CD @ $102/hr and 1.5 hrs
DP @ $128/hr for updating validation checks to include “V 12 done/Patient Completion” check.
	  	345.00	  	 	  	 	  	 	  	 	  	 	  	 	  	345.00	 	 	345.00
	 Total Contract
	  	 	  	2,938,571.00	  	934,245.00	  	3,872,816.00	  	343,110.00	  	1,658,465.00	  	5,874,391.00	  	(1,318,832.81	)	 	4,555,558.19

  

 Page 14 of 15 

																	
	 Unit Cost

	  	Original
Study Total

	  	Adjustment
Amendment
2

	  	 Revised
 Study Total
($US)

	  	Adjustment
Amendment
3 Occurring
to Nov.
2001

	  	Adjustment
Amendment
3 Occurring
post Nov.
2001

	  	Revised
Study Total
($US)

	  	Adjustment
Amendment
4

	  	 Revised
 Study Total
($US)

	  	  	  	Amendment
2

	  	  	  	Amendment
#3

	  	  	Amendment
#4

	Pass-through Costs: SPONSOR shall reimburse CONTRACTOR for reasonable pass-through costs (e.g., travel, lodging, meals) at net thirty (30) days term upon
receipt of original receipt(s)/invoice. Interest at 15% shall apply if net thirty (30) days terms are not satisfied.
	Additional Service Fees: This amendment includes estimated services up to July 31, 2003. PRA will not undertake further work beyond July 31, 2003 without a signed
changeorder.

  

 Page 15 of 15

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