Document:

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                                                                    EXHIBIT 10.1

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                      CHRONIC CARE SOLUTIONS HOLDING, INC.

                             STOCKHOLDERS' AGREEMENT

                         Dated as of September 30, 2005

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                                TABLE OF CONTENTS

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1.  Additional Offerings.................................................     1
    1.1.   Additional Offerings; Generally...............................     1
    1.2.   Exercise of Purchase Rights...................................     2
    1.3.   Sale of Unpurchased Securities................................     2
    1.4.   Future Additional Offerings...................................     3

2.  Restrictions on Transfers of Shares Held by the Employee
    Stockholders.........................................................     3
    2.1.   General Restrictions on Transfer..............................     3
    2.2.   Permitted Transferees.........................................     3

3.  Tag-Along Rights.....................................................     3

4.  Drag-Along Right.....................................................     4

5.  Rights to Purchase Shares from the Employee Stockholders.............     6
    5.1.   Repurchase Rights.............................................     6
    5.2.   Notice........................................................     6
    5.3.   Payment and Delivery of Certificates..........................     7

6.  Election of Directors; Committees....................................     7
    6.1.   Board Make-up.................................................     7
    6.2.   Post Qualified Public Offering Board Seats....................     7
    6.3.   Replacement Directors.........................................     8
    6.4.   Committees....................................................     8
    6.5.   Directors of Subsidiaries.....................................     8
    6.6.   Voting Rights.................................................     8

7.  Legends..............................................................     9

8.  Covenants, Representations and Warranties............................    10
    8.1.   Information Rights............................................    10
    8.2.   No Other Arrangements or Agreements...........................    10

9.  Amendment, Modification, Supplement and Waiver.......................    11

10. Termination of Rights and Obligations Under Certain Sections.........    11

11. Parties..............................................................    11
    11.1.  Assignment Generally..........................................    11
    11.2.  Termination...................................................    11
    11.3.  Agreements to Be Bound........................................    11

12. Recapitalizations, Exchanges, etc. Affecting the Shares..............    12
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<S>                                                                         <C>
13. Further Assurances...................................................    12

14. Governing Law........................................................    12

15. Invalidity of Provision..............................................    12

16. Notices..............................................................    12

17. Headings; Execution in Counterparts..................................    13

18. Entire Agreement.....................................................    13

19. Injunctive Relief....................................................    13

20. Defined Terms........................................................    14
    20.1.  Affiliate.....................................................    14
    20.2.  Awards........................................................    14
    20.3.  Change in Control.............................................    14
    20.4.  Closing Date..................................................    14
    20.5.  Common Stock..................................................    14
    20.6.  Convertible Securities........................................    14
    20.7.  Equity Securities.............................................    14
    20.8.  Exchange Act..................................................    14
    20.9.  Fair Market Value.............................................    14
    20.10. Investors.....................................................    15
    20.11. Majority Employee Stockholders................................    15
    20.12. Mandatory Conversion..........................................    15
    20.13. Other Shares..................................................    15
    20.14. Owns, Own or Owned............................................    15
    20.15. Permitted Assignee............................................    15
    20.16. Person........................................................    15
    20.17. Prime Rate....................................................    15
    20.18. Promissory Note...............................................    15
    20.19. Qualified Public Offering.....................................    16
    20.20. Registration Rights Agreement.................................    16
    20.21. Repurchase Price..............................................    16
    20.22. Requisite Institutional Investors.............................    16
    20.23. Stock Incentive Plan..........................................    16
    20.24. Securities Act................................................    16
    20.25. Shares........................................................    16
    20.26. SPA Shares....................................................    16
    20.27. Transfer......................................................    16
    20.28. Warburg Pincus................................................    17

21. Grant of Irrevocable Proxy...........................................    17
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                             STOCKHOLDERS' AGREEMENT

     This STOCKHOLDERS' AGREEMENT (this "Agreement") is dated as of September
30, 2005 and is entered into by and among Chronic Care Solutions Holding, Inc.,
a Delaware corporation (the "Company"), the institutional investor(s) whose
name(s) and address(es) are set forth from time to time on Schedule I hereto
(the "Institutional Investors") and those employees of the Company and certain
of its subsidiaries whose names and addresses are set forth on Schedule II
hereto (such employees and each of their respective Permitted Transferees are
hereinafter collectively referred to as the "Employee Stockholders").
Capitalized terms used herein without definition elsewhere in this Agreement are
defined in Section 20 hereof.

                                    RECITALS

     WHEREAS, on August 12, 2005, CCS Acquisition, Inc., a Delaware corporation
and an indirect wholly owned subsidiary of the Company ("CCSA"), entered into an
Agreement and Plan of Merger (the "MPTC Agreement") with MPTC Merger Sub, Inc.,
a Florida corporation ("MPTC Merger Sub"), and MPTC Holdings, Inc., a Florida
corporation ("MPTC"), pursuant to which MPTC Merger Sub will merge with and into
MPTC, with MPTC being the surviving corporation and a wholly owned subsidiary of
CCSA;

     WHEREAS, on August 30, 2005, CCSA entered into an Agreement and Plan of
Merger (the "CCS Agreement") with CCS Merger Sub, Inc., a Delaware corporation
("CCS Merger Sub"), and Chronic Care Solutions, Inc., a Delaware corporation
("CCS"), pursuant to which CCS Merger Sub will merge with and into CCS, with CCS
being the surviving corporation and a wholly owned subsidiary of CCSA;

     WHEREAS, in connection with the consummation of the transactions
contemplated by the MPTC Agreement and the CCS Agreement, the Investors have
entered into a Securities Purchase Agreement with the Company (the "Purchase
Agreement"), pursuant to which the Company has issued and sold to each Investor
and each Investor has purchased from the Company shares of Series A Convertible
Preferred Stock of the Company (the "Preferred Stock");

     WHEREAS, the powers, rights and preferences, restrictions and other matters
relating to the Common Stock and Preferred Stock are set forth in the Restated
Certificate of Incorporation of the Company (the "Restated Certificate"); and

     WHEREAS, the Investors and the Company desire to promote their mutual
interests by agreeing to certain matters relating to the operations of the
Company, the disposition and voting of the capital stock of the Company and
certain other matters set forth herein.

     NOW, THEREFORE, in consideration of the mutual covenants and obligations
set forth in this Agreement, and to implement the foregoing, the parties hereto
agree as follows:

1. Additional Offerings.

     1.1. Additional Offerings; Generally. If at any time after the date hereof,
the Company or any direct or indirect subsidiary of the Company (each a
"Subsidiary") proposes to

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issue any Equity Securities (other than the issuance of any Equity Securities
(i) pursuant to the public in a firm commitment underwriting pursuant to a
registration statement filed under the Securities Act, (ii) pursuant to the
acquisition of another Person by the Company or any Subsidiary (as consideration
for the acquisition and not for the purpose of financing an acquisition),
whether by purchase of stock, merger, consolidation, purchase of all or
substantially all of the assets of such Person or otherwise, (iii) pursuant to
an employee stock option plan, stock bonus plan, stock purchase plan or other
management equity program, including without limitation the Stock Incentive
Plan, approved by a majority of the members of the Board of Directors of the
Company (the "Board") (which majority shall include at least two (2) Warburg
Directors), (iv) by a Subsidiary to the Company or any other Subsidiary of the
Company or (v) in the form of warrants to purchase Common Stock issued to
lessors of property and/or equipment or to financial institutions or related
entities in connection with commercial credit or debt financing or other similar
arrangements which are approved by a majority of the members of the Board),
then, as to each Institutional Investor that Owns at least five percent (5%) of
the Common Stock (each such Person is hereinafter referred to, for purposes of
this Section 1, as a "Participating Investor" and collectively, such Persons are
referred to in this Section 1 as the "Participating Investors"), the Company
shall:

          (a) give written notice (the "Subscription Right Notice") setting
     forth in reasonable detail (i) the designation and all of the terms and
     provisions of the Equity Securities proposed to be issued (the "Proposed
     Securities"), including, where applicable, the voting powers, preferences
     and relative participating, optional or other special rights, and the
     qualification, limitations or restrictions thereof and interest rate and
     maturity; (ii) the price and other terms of the proposed sale of such
     Proposed Securities; and (iii) the amount of such Proposed Securities
     proposed to be issued; and

          (b) offer to issue to each Participating Investor that number of
     Proposed Securities equal to the number of Proposed Securities multiplied
     by such Participating Investor's Percentage Interest. For purposes hereof,
     "Percentage Interest" shall mean, in respect of any Participating Investor,
     the percentage determined by dividing (x) the number of shares of Common
     Stock Owned by such Participating Investor, by (y) the total number of
     shares of Common Stock Owned by the Investors.

     1.2. Exercise of Purchase Rights. Each Participating Investor may exercise
its purchase rights hereunder within twenty (20) business days after receipt of
the Subscription Right Notice. If all of the Proposed Securities offered to the
Participating Investors are not fully subscribed by such Participating
Investors, the remaining Proposed Securities will be reoffered to the
Participating Investors upon the terms set forth in this Section 1, until all
such Proposed Securities are fully subscribed for or until all such
Participating Investors have subscribed for all such Proposed Securities which
they desire to purchase, except that such Participating Investors must exercise
their purchase rights within ten (10) business days after receipt of all such
reoffers. To the extent that the Company or any Subsidiary, as the case may be,
offers two or more securities in units, the Participating Investor must purchase
such units as a whole and will not be given the opportunity to purchase only one
of the securities making up such unit.

     1.3. Sale of Unpurchased Securities. Upon the expiration of the offering
periods described above, the Company or any Subsidiary, as the case may be, will
be free to sell such

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Proposed Securities that the Participating Investors have not elected to
purchase during the ninety (90) calendar day period immediately following such
expiration on terms and conditions no more favorable to the purchasers thereof
than those offered to the Participating Investors. Any Proposed Securities
offered or sold by the Company or any Subsidiary, as the case may be, after such
ninety (90) calendar day period must be reoffered to the Participating Investor
pursuant to this Section 1.

     1.4. Future Additional Offerings. The election by the Participating
Investor not to exercise its subscription rights under this Section 1 in any one
instance shall not affect its right (other than in respect of a reduction in its
percentage holdings) as to any subsequent proposed issuance.

2. Restrictions on Transfers of Shares Held by the Employee Stockholders.

     2.1. General Restrictions on Transfer. No Shares owned by any Employee
Stockholder nor any interest therein nor any rights relating thereto may be
Transferred by such Employee Stockholder, except for Transfers of Shares (i) to
a Permitted Transferee or (ii) pursuant to Section 3, Section 4 or Section 5 of
this Agreement.

     2.2. Permitted Transferees. Subject to this Section 2 and Section 11, an
Employee Stockholder may Transfer any Shares owned by him or her or any interest
therein (i) for estate-planning purposes of such Employee Stockholder and with
the prior written consent of the Board, which consent shall not be unreasonably
withheld, to (w) a trust under which the distribution of the Shares Transferred
thereto may be made only to beneficiaries who are such Employee Stockholder, his
or her spouse, his or her parents, members of his or her immediate family or his
or her lineal descendants (collectively, "Permitted Family Members"), (x) a
corporation the stockholders of which are only such Employee Stockholder or
Permitted Family Members, (y) a limited liability company the members of which
are only such Employee Stockholder or Permitted Family Members or (z) a
partnership, or a limited liability partnership, the partners of which are only
such Employee Stockholder or Permitted Family Members or (ii) in case of the
death of an Employee Stockholder, by will or by the laws of intestate
succession, to his or her executors, administrators, testamentary trustees,
legatees or beneficiaries (each such Person to which a Transfer is permitted
pursuant to clauses (i) and (ii) immediately above is hereinafter referred to as
a "Permitted Transferee" and collectively, as the "Permitted Transferees");
provided, however, that in each such case, the Shares so Transferred shall be
subject to all provisions of this Agreement as though the transferring Employee
Stockholder were still the holder of such Shares; provided further, however,
that if a Permitted Transferee ceases to meet the foregoing definition of
Permitted Transferee, it shall immediately transfer any Shares held by it to the
Employee Stockholder that made the Transfer of such Shares or to another
Permitted Transferee designated by such Employee Stockholder.

3. Tag-Along Rights.

     3.1. Subject to the other terms of this Section 3, no Investor shall be
permitted to Transfer any Shares to one or more third parties unless each other
Investor is offered a right to participate in such Transfer for a purchase price
per Share equal to the purchase price to be received by such Investor then
proposing to sell the Shares (the "Selling Investor") and on other

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terms and conditions not less favorable to such other Investor than those
applicable to the Selling Investor. Any Investor who, in accordance with the
terms of Section 3.2 below, notifies the Selling Investor that it desires to
participate in any sale of Shares shall have the right to include in such sale
an amount of Shares equal to the amount of Shares the third party actually
proposes to purchase multiplied by the percentage obtained by dividing the
number of Shares (including shares of vested restricted Common Stock and
restricted Common Stock that would vest upon such sale) owned by such
participating Investor by the aggregate number of Shares (including shares of
vested restricted Common Stock and restricted Common Stock that would vest upon
such sale) owned by the Selling Investor and each other Investor exercising its
right to participate in such sale pursuant hereto. For the purposes of this
Section 3.1, a sale to a "third party" shall not include a sale to any Permitted
Transferee or Permitted Assignee or a sale pursuant to an effective registration
statement (a "Registration Statement"). Notwithstanding the foregoing, in the
event the Selling Investor is selling only shares of Preferred Stock, holders of
Common Stock shall not have the right to sell shares of Common Stock pursuant to
this Section 3.1. In calculating the percentage used to calculate the number of
shares of Stock that such holders are entitled to sell, the percentages for
Preferred Stock and Common Stock shall be separately calculated.

     3.2 In the event a Selling Investor is proposing to sell any Shares and,
pursuant to this Section 3, the Investors are entitled to participate in such
sale, such Selling Investor shall notify each Investor entitled to participate
therein in writing of such proposed sale and its terms and conditions (and shall
provide any other information regarding the proposed transfer that such other
Investor may reasonably request). Within fifteen (15) business days of the date
of such notice, each Investor entitled to participate therein shall notify such
Selling Investor if it elects to participate in such sale. Any Investor that
fails to notify the Selling Investor within such fifteen (15) business day
period shall be deemed to have waived its rights hereunder with respect to such
sale. Notwithstanding anything contained in this Section 3 to the contrary, in
the event that all or a portion of the purchase price for the Shares being
purchased consists of securities and the sale of such securities to any Investor
entitled to participate therein would, by virtue of the fact that such Investor
is not an "accredited investor" (within the meaning of Rule 501(a) under the
Securities Act), require either a registration under the Securities Act or the
preparation of a disclosure document pursuant to Regulation D under the
Securities Act (or any successor regulation) or a similar provision of any state
securities law, then, at the option of the Selling Investor, any one or more of
such Investors may receive, in lieu of such securities, the fair market value of
such securities in cash, as determined in good faith by the Board.

4. Drag-Along Right.

     4.1 If the Institutional Investors are proposing to sell to one or more
third parties in excess of fifty percent (50%) of the number of Shares owned by
them, the Institutional Investors shall have the right, but not the obligation,
to require each other Investor to sell, in accordance with the immediately
following sentence hereof, all or a portion of such other Investor's Shares
(including shares of vested restricted Common Stock and restricted Common Stock
that would vest upon such sale) in such sale. In the event the Institutional
Investors require the other Investors to sell all or a portion of their Shares
(including shares of vested restricted Common Stock and restricted Common Stock
that would vest upon such sale) pursuant to this Section 4.1 such other
Investors shall be required to include in such sale an amount of Shares
(including

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shares of vested restricted Common Stock and restricted Common Stock that would
vest upon such sale) equal to the aggregate number of Shares (including shares
of vested restricted Common Stock and restricted Common Stock that would vest
upon such sale) owned by such other Investor as of the date of the proposed sale
multiplied by a fraction, the numerator of which shall be the number of Shares
that the Institutional Investors are proposing to sell in such sale, and the
denominator of which is the aggregate number of Shares owned by the
Institutional Investors, in each case, as of the date of the proposed sale. An
Investor required to sell any Shares pursuant to this Section 4.1, shall be
entitled to receive in exchange therefor an amount per share equal to the
purchase price received per share of Common Stock Owned by the Institutional
Investors in connection with such sale; provided, however that, if the
Institutional Investors own Preferred Stock, such per share amount shall be
calculated after giving effect to the payment of the Liquidation Preference (as
defined in the Restated Charter) to all holders of Preferred Stock. Such
Investors shall otherwise participate in such transaction on other terms and
conditions not less favorable to such Investors than those applicable to the
Institutional Investors and, subject to Section 4.3 below, shall receive the
same type of consideration received by the Institutional Investors in such
transaction. In the event that any such transaction involves the merger of the
Company with or into a third party or, in the event that in lieu of the sale of
Shares, the transaction involves the sale by the Company of all or substantially
all of the Company's assets to any third party, or if such transaction otherwise
requires the vote of the Company's stockholders, each Investor hereby agrees to
vote all Shares then owned by such Investor in favor of such transaction, waive
any dissenter or appraisal right he, she or it may have in respect of such
transaction and to otherwise to take all steps necessary (including delivery of
certificates or other instruments evidencing the shares to be conveyed, duly
endorsed and in negotiable form with all the requisite documentary stamps
affixed thereto) to enable him, her or it to comply with the provisions of this
Section 4.1 to facilitate any such transaction. For the purposes of this Section
4, a sale to a "third party" shall not include a sale to any Permitted Assignee
or a sale pursuant to a Registration Statement.

     4.2. To exercise the rights granted under Section 4.1, the Institutional
Investors shall give each other Investor a written notice, not less than fifteen
(15) days prior to the proposed sale, containing (i) the name and address of the
proposed transferee(s) and (ii) the proposed purchase price with respect to the
Shares, terms of payment and other material terms and conditions of the offer of
the proposed transferee(s). Each Investor shall thereafter be obligated to sell
its Shares to the proposed transferee(s) or vote its Shares in favor of the
proposed transaction, as the case may be, in accordance with Section 4.1.

     4.3 Notwithstanding anything contained in this Section 4 to the contrary,
in the event that all or a portion of the purchase price for the Shares being
purchased consists of securities and the sale of such securities to an Investor
entitled to participate therein would, by virtue of the fact that such Investor
is not an "accredited investor" (within the meaning of Rule 501(a) under the
Securities Act), require either a registration under the Securities Act or the
preparation of a disclosure document pursuant to Regulation D under the
Securities Act (or any successor regulation) or a similar provision of any state
securities law, then, at the option of the Institutional Investors, any one or
more of such Investors may receive, in lieu of such securities, the fair market
value of such securities in cash, as determined in good faith by the Board.

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5. Rights to Purchase Shares from the Employee Stockholders.

     5.1. Repurchase Rights. Subject to Section 5.2, if, prior to the time that
the Company completes a Qualified Public Offering, an Employee Stockholder's
employment or service with the Company or any Subsidiary terminates for any
reason, during the period commencing on the date of such termination and ending
on the date that the Company completes a Qualified Public Offering, in addition
to any repurchase right of the Company or the Institutional Investors, as the
case may be, with respect to unvested shares of Restricted Stock (as defined in
the Stock Inventive Plan) as provided in the Stock Incentive Plan, the Company
and, to the extent the Company does not exercise such right, the Institutional
Investors, shall have the right, but not the obligation, to purchase from such
Employee Stockholder, and such Employee Stockholder shall have the obligation to
sell to the Company or the Institutional Investors, as the case may be, all, but
not less than all of the Shares (including Shares acquired pursuant to a stock
or option grant) owned by such Employee Stockholder as of the date of repurchase
at a per share price equal to the Repurchase Price (such right, the "Repurchase
Right").

          (a) If the Company or the Institutional Investors, as the case may be,
     exercises the Repurchase Right following such Employee Stockholder's
     termination of employment or service, as applicable, (i) by the Company or
     any Subsidiary without Cause (as defined in the Stock Incentive Plan) or
     (ii) as a result of death or permanent disability of the Employee
     Stockholder, the aggregate Repurchase Price for all SPA Shares and Other
     Shares so repurchased shall be paid in a lump-sum at the time of
     repurchase.

          (b) If the Company or the Institutional Investors, as the case may be,
     exercises the Repurchase Right following an Employee Stockholder's
     termination of employment or service, as applicable, by the Company or any
     Subsidiary for Cause (as defined in the Stock Incentive Plan), the
     aggregate Repurchase Price for such SPA Shares and Other Shares repurchased
     shall be paid in a lump-sum at the time of repurchase, or, in the sole
     discretion of the Company or the Institutional Investors, as the case may
     be, in the form of the Promissory Note.

          (c) If the Company or the Institutional Investors, as the case may be,
     exercises the Repurchase Right following an Employee Stockholder's
     termination of employment or service, as applicable, by the Employee
     Stockholder for any other reason, (i) the aggregate Repurchase Price for
     such SPA Shares repurchased shall be paid in a lump-sum at the time of
     repurchase, and (ii) the aggregate Repurchase Price for such Other Shares
     repurchased shall be paid in a lump-sum at the time of repurchase, or, in
     the sole discretion of the Company or the Institutional Investors, as the
     case may be, in the form of the Promissory Note.

     5.2. Notice. If the Company or the Institutional Investors, as the case may
be, desires to purchase any Shares from an Employee Stockholder pursuant to
Section 5.1, it shall notify such Employee Stockholder (or his or her a
Permitted Transferee) in writing at any time prior to the later of the 183rd day
following such termination and the date on which all non-competition covenants
applicable to such Employee Stockholder in respect of the Company or any
Subsidiary

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(including without limitation such restrictive covenants contained in an
Employee Stockholder's employment agreement) expire or otherwise terminate.

     5.3. Payment and Delivery of Certificates. Payment for any Shares purchased
by the Company or the Institutional Investors, as the case may be, by reason of
an event described in Section 5 shall be made on or prior to the date that is
thirty (30) days following the date of the receipt by the Employee Stockholder
or his or her Permitted Transferee, as the case may be, of the Company's or the
Institutional Investors', as the case may be, notice pursuant to Section 5.2. At
the closing, the Employee Stockholder or his or her Permitted Transferee, as the
case may be, shall deliver to the Company or the Institutional Investors, as the
case may be, the certificates or other instruments evidencing the Shares to be
conveyed, duly endorsed and in negotiable form with all the requisite
documentary stamps affixed thereto, and free and clear of any lien or other
encumbrance.

6. Election of Directors; Committees.

     6.1. Board Make-up. As of the date hereof (after giving effect to the
transactions contemplated by the Purchase Agreement), the Board shall consist of
Joel Ackerman, David Wenstrup, Howard Deutsch, and Joseph Capper. From and after
the date hereof, and until the time that the Company completes a Qualified
Public Offering, the Investors and the Company shall take all action within
their respective power, including, but not limited to, the voting of all Shares
Owned by them, required to cause the Board to consist of up to six (6) members
or such other number of members as requested from time to time by the
Institutional Investors, and at all times throughout the term of this Agreement,
to include:

          (a) for as long as the Institutional Investors Own at least twenty
     percent (20%) of the Common Stock Owned by Investors, four (4) members
     designated by Warburg Pincus and, for as long as the Institutional
     Investors Own at least five percent (5%) but less than twenty percent (20%)
     of the Common Stock Owned by Investors, one (1) member designated by
     Warburg Pincus (such members referred to herein as "Warburg Directors" and
     each a "Warburg Director"); and

          (b) two (2) other directors reasonably acceptable to the Institutional
     Investors (the "Other Directors").

     The parties hereto acknowledge that the four (4) representatives to be
designated by Warburg Pincus are initially the directors that the holders of
Preferred Stock are entitled to elect under the Restated Certificate. The
parties hereto further acknowledge that two of the initial Warburg Directors
shall be Joel Ackerman and David Wenstrup and the initial Other Directors shall
be Howard Deutsch, as Executive Chairman, and Joseph Capper, as Chief Executive
Officer. The parties hereto further acknowledge that Warburg Pincus may
designate the other Warburg Directors at anytime as contemplated hereby.

     6.2. Post Qualified Public Offering Board Seats. From the date on which the
Company completes a Qualified Public Offering, and (x) for as long as the
Institutional Investors together with any Affiliate thereof beneficially own
(within the meaning of Rule 13d-3 under the Exchange Act) at least ten percent
(10%) of the outstanding shares of Common Stock, the

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Company will nominate and use its best efforts to have elected to the Board two
(2) individuals designated by Warburg Pincus and (y) for as long as the
Institutional Investors together with any Affiliate thereof beneficially own
(within the meaning of Rule 13d-3 under the Exchange Act) at least five percent
(5%) but less than ten percent (10%) of the outstanding shares of Common Stock,
the Company will nominate and use its best efforts to have elected to the Board
one (1) individual designated by Warburg Pincus (it being understood that the
foregoing is not a limitation on the number of directors that the Institutional
Investors may have the right to nominate to the Board).

     6.3. Replacement Directors. In the event that any Warburg Director (each, a
"Withdrawing Director") designated in the manner set forth in Section 6.1 hereof
is unable to serve, or once having commenced to serve, is removed or withdraws
from the Board, such Withdrawing Director's replacement (the "Substitute
Director") will be designated by Warburg Pincus. The Investors and the Company
agree to take all action within their respective power, including, but not
limited to, the voting of all Shares Owned by them (i) to cause the election of
such Substitute Director promptly following his or her nomination pursuant to
this Section 6.3 and (ii) upon the written request of Warburg Pincus to remove,
with or without cause, any of the Warburg Directors.

     6.4. Committees. Subject to applicable law and any rules or regulations of
any stock exchange or automated dealer quotation system on which the Common
Stock is listed, in the event the Board shall at any time create a committee of
the Board, any such committee shall have at least one (1) Warburg Director so
long as Warburg Pincus is entitled to elect at least one (1) member of the
Board; provided, however, that the foregoing shall not apply to any committee
formed to consider a transaction between the Company and Warburg Pincus or its
Affiliates.

     6.5. Directors of Subsidiaries. Subject to applicable law and any rules or
regulations of any stock exchange or automated dealer quotation system on which
the Common Stock is listed, for so long as Warburg Pincus is entitled to elect
at least one (1) member of the Board, Warburg Pincus shall be entitled to
designate one (1) director (which director shall be one of the Warburg
Directors) to the board of directors of each Subsidiary. In the event that
Warburg Pincus exercises its right pursuant to this Section 6.5, the Company
shall take all action within its power to cause such designee to be appointed to
such boards.

     6.6. Voting Rights. Without the approval of the Board, which approval must
include the affirmative vote of at least two (2) Warburg Directors (or in the
event that there is only one (1) Warburg Director, the affirmative vote of such
Warburg Director), the Company will not, and will not permit any Subsidiary to:

          (a) sell, lease, or dispose of assets in excess of $2,000,000 outside
     of the ordinary course of business;

          (b) incur indebtedness for borrowed money in excess of $10,000,000 in
     any fiscal year;

                                        8

<PAGE>

          (c) make capital expenditures in any fiscal year in excess of an
     amount equal to 110% of the capital expenditures described in the operating
     plan of the Company approved by the Board (the "Operating Plan") for such
     fiscal year;

          (d) engage in any material business or activity other than that
     described in the Operating Plan;

          (e) materially change its accounting methods or policies or change its
     auditors;

          (f) hire or terminate, or materially amend or modify the employment
     term (including compensation) of the executive chairman, chief executive
     officer or chief financial officer of the Company;

          (g) enter into any transaction, other than employment agreements on a
     basis consistent with past practice, with any officer, director or
     beneficial owner of five percent (5%) or more of the Common Stock or any
     affiliate of any of the foregoing other than on terms and conditions not
     less favorable to the Company than could be obtained on an arm's-length
     basis from unrelated third parties;

          (h) increase the compensation of its senior executives other than as
     described in the Operating Plan;

          (i) approve the Operating Plan; or

          (j) take, agree to take or resolve to take any actions in furtherance
     of any of the foregoing.

7. Legends. A copy of this Agreement shall be filed with the Secretary of the
Company and kept with the records of the Company. Each certificate or other
instrument representing Shares owned by any Investor shall bear upon its face
the following legends, as appropriate:

          (i) THE SECURITIES EVIDENCED BY THIS CERTIFICATE HAVE BEEN ACQUIRED
     FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
     1933, AS AMENDED (THE "ACT"), OR ANY STATE SECURITIES LAW AND MAY NOT BE
     OFFERED, SOLD, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF
     UNLESS AND UNTIL REGISTERED UNDER THE ACT AND ANY APPLICABLE STATE
     SECURITIES LAWS UNLESS, IN THE OPINION OF COUNSEL TO THE HOLDER OF SUCH
     SECURITIES, WHICH COUNSEL MUST BE, AND THE FORM AND SUBSTANCE OF WHICH
     OPINION ARE, REASONABLY SATISFACTORY TO CHRONIC CARE SOLUTIONS HOLDING,
     INC. (THE "COMPANY"), SUCH OFFER, SALE, ASSIGNMENT, PLEDGE, HYPOTHECATION,
     TRANSFER OR OTHER DISPOSITION IS EXEMPT FROM REGISTRATION OR IS OTHERWISE
     IN COMPLIANCE WITH THE ACT, SUCH LAWS AND THE STOCKHOLDERS' AGREEMENT DATED
     AS OF SEPTEMBER 30, 2005, BY AND AMONG THE COMPANY, WARBURG PINCUS PRIVATE
     EQUITY IX, L.P. AND THOSE OTHER PARTIES NAMED THEREIN (THE "STOCKHOLDERS'
     AGREEMENT").

                                        9

<PAGE>

          (ii) THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO
     RESTRICTIONS ON TRANSFER AND OTHER CONDITIONS, AS SPECIFIED IN THE
     STOCKHOLDERS' AGREEMENT, COPIES OF WHICH ARE ON FILE AT THE OFFICE OF THE
     COMPANY AND WILL BE FURNISHED WITHOUT CHARGE TO THE HOLDER OF SUCH
     SECURITIES UPON WRITTEN REQUEST.

In addition, certificates representing Shares shall bear any legends required by
the applicable laws of any states.

8. Covenants, Representations and Warranties.

     8.1. Information Rights. At any time that the Company is not required to
file periodic reports pursuant to the Exchange Act, or, if required and the
Company fails to file such required periodic reports with the Securities and
Exchange Commission (the "SEC") for any reason whatsoever, the Company shall
provide to each Investor that Owns at least fifteen percent (15%) of the
outstanding shares of Common Stock by electronic means or otherwise, essentially
the same financial statements that would be contained in Annual Reports on Form
10-K and in Quarterly Reports on Form 10-Q, if the Company were required to
file, or did not fail to file, such periodic reports, it being understood and
agreed that such information shall (a) be provided to the Investors no later
than the date on which the Company would have been required to file such report
with the SEC and (b) include, without limitation, annual audited financial
statements and unaudited quarterly financial statements, each prepared in
accordance with generally accepted accounting principles. Without limiting the
foregoing, from and after the date hereof, on reasonable prior written notice,
the Company and any Subsidiary shall make their respective representatives
reasonably available to each Investor that Owns at least 15% of the Common Stock
Owned by all Investors to discuss the business, results of operations and other
matters pertaining to the Company and any Subsidiary. Any and all information
provided to any Investor pursuant to the terms of this Agreement (other than any
information that is generally available to the public through no breach of the
terms of this Agreement) shall be treated as confidential information by such
Investor and such Investor shall use its reasonable best efforts to ensure that
such information is not disclosed or otherwise divulged to any third party
(other than such Investor's counsel, accountants and other professional advisors
in connection with services being performed by any such professional for such
Investor and to the members, partners and limited partners of the Investors
entitled to information under this Section 8.1).

     8.2. No Other Arrangements or Agreements. Each Employee Stockholder hereby
represents and warrants to the Company and each other Investor that, except as
set forth in this Agreement and except for (a) the Registration Rights
Agreement, (b) any written agreement between such Employee Stockholder and the
Company or any Subsidiary, and (c) any Award Agreement between such Employee
Stockholder and the Company, each as amended from time to time, he or she has
not entered into or agreed to be bound by any other arrangements or agreements
of any kind with any other party with respect to any Shares of the Company,
including, but not limited to, arrangements or agreements with respect to the
acquisition, disposition or voting of any Shares of the Company or any interest
therein (whether or not such arrangements and agreements are with the Company,
any Subsidiary, other Investors or holders of capital stock of the Company that
are not parties to this Agreement).

                                       10

<PAGE>

9. Amendment, Modification, Supplement and Waiver. This Agreement may be
amended, modified or supplemented, and the enforcement of any provision hereof
may be waived, with, and only with, the prior written consent of the Company and
the Requisite Institutional Investors; provided, however, that the terms of
Sections 2.2, 3, 5 and 10 hereof and the terms of this proviso may be amended,
modified, supplemented or waived with, and only with, the prior written consent
of the Company, the Requisite Institutional Investors and the Majority Employee
Stockholders. Subject to the terms of the proviso contained in the immediately
preceding sentence hereof, if the Company and the Requisite Institutional
Investors shall have so agreed, any such amendment, modification, supplement or
waiver shall be effective with respect to all of the Investors hereunder,
whether or not such Investor shall have agreed to such amendment, modification,
supplement or waiver, and the Company shall promptly notify all other Investors
who have not so agreed of the material terms of such amendment, modification,
supplement or waiver and the effective date thereof.

10. Termination of Rights and Obligations Under Certain Sections. All rights and
obligations pursuant to Sections 1, 2, 3, 4, 5, 6.1, 6.3, 6.4, 6.5, 6.6, 11, 12
and 21 of this Agreement shall terminate upon the earlier of the closing of a
Qualified Public Offering and a Change in Control. Without limiting the
foregoing, this Agreement or any portion thereof shall terminate upon the
written consent of the Company and the Requisite Institutional Investors;
provided, however, that except as contemplated by the first sentence of this
Section 10, the written consent of the Company, the Requisite Institutional
Investors and the Majority Employee Stockholders shall be required to terminate
or otherwise eliminate any of the terms of Sections 2, 3 or 5 hereof or this
proviso of this Section 10.

11. Parties.

     11.1. Assignment Generally. The provisions of this Agreement shall be
binding upon and inure to the benefit of the parties hereto and their respective
heirs, legal representatives, successors and assigns; provided, that no Investor
shall be permitted to assign any of his, her or its obligations pursuant to this
Agreement without the prior written consent of the Company and the Institutional
Investors, unless such assignment is in connection with a Transfer explicitly
permitted by this Agreement and, prior to such assignment, such assignee
complies with the requirements of Section 11.3 hereof.

     11.2. Termination. Any party to, or Person who is subject to, this
Agreement that ceases to Own any Shares shall cease to be a party to, or Person
who is subject to, this Agreement and thereafter shall have no rights or
obligations hereunder; provided, however, that a Transfer of Shares not
explicitly permitted under this Agreement shall not relieve any Investor of any
of his, her or its obligations hereunder.

     11.3. Agreements to Be Bound.

          (a) Notwithstanding anything to the contrary contained in this
Agreement, any Transfer (other than pursuant to Section 3, Section 4 or Section
5 of this Agreement) of Shares by an Employee Stockholder shall be permitted
under the terms of this Agreement only if the transferee (i) shall agree in
writing to be bound by the terms and conditions of this Agreement and shall
evidence such agreement by executing a joinder agreement, the form of which is

                                       11

<PAGE>

attached as Exhibit A hereto (the "Joinder Agreement") and (ii) shall cause his
or her spouse, if any, to execute a spousal waiver in form and substance
satisfactory to the Board, if such transferee is an individual who resides in a
state with a community property system. Upon the execution of the joinder
agreement and, if applicable, the spousal waiver by the spouse of such
transferee, such transferee shall be deemed to be an Employee Stockholder, and
all Shares so Transferred shall be deemed Shares for all purposes of this
Agreement, except as otherwise provided in the joinder agreement.

          (b) Notwithstanding anything to the contrary contained in this
Agreement, as a condition precedent to the effectiveness of any Transfer of
Shares by any Institutional Investor, the transferee thereof shall be required
to agree in writing to be bound by the terms and conditions of this Agreement
pursuant to an instrument of assumption reasonably satisfactory in substance and
form to the Board.

12. Recapitalizations, Exchanges, etc. Affecting the Shares. Except as otherwise
provided herein, the provisions of this Agreement shall apply to the fullest
extent set forth herein with respect to (a) the Shares and (b) any and all
Equity Securities of the Company or any successor or assign of the Company
(whether by merger, consolidation, sale of assets or otherwise) which may be
issued in respect of, in exchange for, or in substitution for the Shares, by
reason of any stock dividend, split, reverse split, combination,
recapitalization, reclassification, merger, consolidation or otherwise. Except
as otherwise expressly provided herein, this Agreement is not intended to
confer, and does not confer, upon any Person, except for the parties hereto, any
rights or remedies hereunder.

13. Further Assurances. Each party hereto or Person subject hereto shall do and
perform or cause to be done and performed all such further acts and things and
shall execute and deliver all such other agreements, certificates, instruments
and documents as any other party hereto or Person subject hereto may reasonably
request in order to carry out the intent and accomplish the purposes of this
Agreement and the consummation of the transactions contemplated hereby.

14. Governing Law. This Agreement and the rights and obligations of the parties
hereunder and the Persons subject hereto shall be governed by, and construed and
interpreted in accordance with, the laws of the State of Delaware, without
giving effect to the choice of law principles thereof.

15. Invalidity of Provision. The invalidity or unenforceability of any provision
of this Agreement in any jurisdiction shall not affect the validity or
enforceability of the remainder of this Agreement in that jurisdiction or the
validity or enforceability of this Agreement, including that provision, in any
other jurisdiction.

16. Notices. All notices, requests, demands, waivers and other communications
required or permitted to be given under this Agreement shall be in writing and
shall be deemed to have been duly given if (a) delivered personally, (b) mailed,
certified or registered mail with postage prepaid, (c) sent by next-day or
overnight mail or delivery or (d) sent by telecopy (including facsimile), as
follows:

          (i) If to the Company, to it at:

                                       12

<PAGE>

               c/o Warburg Pincus Private Equity IX, L.P.
               466 Lexington Avenue
               New York, New York  10017
               Facsimile No.: (212) 878-9100
               Attention: David Wenstrup

          (ii) If to any Institutional Investor or any Employee Stockholder, to
     such Institutional Investor or Employee Stockholder, as the case may be, at
     the address or facsimile number listed on Schedule I and Schedule II
     hereto, respectively, or as such Institutional Investor or Employee
     Stockholder shall designate to the Company in writing in accordance with
     the terms hereof, with a copy to the Company and the Investors at their
     respective addresses indicated herein;

or, in each case, to such other Person or address as any party shall specify by
notice in writing to the Company and the Investors. Any notice so addressed
shall be deemed to be given: if delivered personally or by telecopy (including
facsimile), on the date of such delivery, if a business day, otherwise on the
first business day thereafter; if mailed by certified or registered mail with
postage prepaid, on the third business day after the date of such mailing; and
if sent by next-day or overnight mail or delivery, on the first business day
following the date of such mailing or delivery.

17. Headings; Execution in Counterparts. The headings and captions contained
herein are for convenience only and shall not control or affect the meaning or
construction of any provision hereof. This Agreement may be executed in any
number of counterparts, each of which shall be deemed to be an original and
which together shall constitute one and the same instrument.

18. Entire Agreement. This Agreement, together with the Purchase Agreement, the
Registration Rights Agreement, the Stock Incentive Plan, any employment
agreement between the Company or any Subsidiary and any party hereto and the
other agreements and documents referenced herein, including in the recitals
hereto (collectively, the "Other Agreements"), embodies the entire agreement and
understanding of the parties hereto in respect of the subject matter contained
herein. There are no restrictions, promises, representations, warranties,
covenants or undertakings relating to the Shares, other than those expressly set
forth or referred to herein and other than those set forth in the Other
Agreements. This Agreement and the Other Agreements supersede all prior
agreements and understandings among the parties with respect to such subject
matter, and it is the understanding of all parties hereto that any such prior
agreement is hereby terminated, null and void as of the Closing Date.

19. Injunctive Relief. The Shares cannot readily be purchased or sold in the
open market, and for that reason, among others, the Company and the Investors
will be irreparably damaged in the event this Agreement is not specifically
enforced. Each of the parties therefore agrees that in the event of a breach of
any provision of this Agreement, the aggrieved party may elect to institute and
prosecute proceedings in any court of competent jurisdiction to enforce specific
performance or to enjoin the continuing breach of this Agreement. Such remedies
shall, however, be cumulative and not exclusive, and shall be in addition to any
other remedy which the Company or the Investors may have. Each party hereto
hereby irrevocably submits to the non-exclusive jurisdiction of the state and
federal courts in New York, New York for the

                                       13

<PAGE>

purposes of any suit, action or other proceeding arising out of or based upon
this Agreement or the subject matter hereof. Each party hereto hereby consents
to service of process by mail made in accordance with Section 16 hereof.

20. Defined Terms. As used in this Agreement, the following terms shall have the
meanings ascribed to them below:

     20.1. Affiliate. "Affiliate" shall mean, with respect to any Person, a
Person directly or indirectly, through one or more intermediaries, controlling,
controlled by, or under common control with, such Person.

     20.2. Awards. "Awards" shall have the meaning ascribed to such term in the
Stock Incentive Plan.

     20.3. Change in Control. "Change in Control" shall mean (i) the sale or
disposition, in one or a series of related transactions, of all or substantially
all of the assets of the Company to any "person" or "group" (as such terms are
defined in Sections 13(d)(3) and 14(d)(2) of the Exchange Act) other than the
Institutional Investors or their Affiliates; (ii) any person or group (together
with their Affiliates), other than the Institutional Investors or their
Affiliates, is or becomes the "beneficial owner" (as defined in Rules 13d-3 and
13d-5 under the Exchange Act), directly or indirectly, of more than fifty
percent (50%) of the total voting power of the voting stock of the Company and
the Institutional Investors or their Affiliates cease to control the Board; or
(iii) any merger, consolidation or similar transaction pursuant to which the
stockholders of the Company immediately prior to such merger, consolidation or
similar transaction own, in the aggregate, less than fifty percent (50%) of the
voting securities of the Company outstanding immediately after such merger,
consolidation or similar transaction and the Institutional Investors or their
Affiliates cease to control the Board.

     20.4. Closing Date. The "Closing Date" shall mean the date on which the
transactions contemplated by the Purchase Agreement close.

     20.5. Common Stock. "Common Stock" shall mean common stock, par value $0.01
per share, of the Company.

     20.6. Convertible Securities. "Convertible Securities" shall mean any
warrants, options or other rights to acquire, and any equity and debt securities
convertible into, capital stock of the Company or any Subsidiary.

     20.7. Equity Securities. "Equity Securities" shall mean any equity
securities of any kind of the Company or any Subsidiary, including any
Convertible Securities.

     20.8. Exchange Act. "Exchange Act" shall mean the Securities Exchange Act
of 1934, as amended.

     20.9. Fair Market Value. "Fair Market Value", for purposes of the
Repurchase Rights set forth in Section 5 of this Agreement, shall mean, at any
time, the amount per Share of

                                       14

<PAGE>

Common Stock or Preferred Stock, as the case may be, that the holder thereof
would be entitled to receive if the Company were sold or liquidated at such
time, based on the fair market value of the Company at such time, which amount
and fair market value shall be determined in good faith by the Board without
regard to a minority discount or discount due to any transfer restrictions.

     20.10. Investors. "Investors" shall mean the Institutional Investors, the
Employee Stockholders and their respective transferees and assigns that become
parties to this Agreement pursuant to Section 11.3 hereof.

     20.11. Majority Employee Stockholders. "Majority Employee Stockholders" as
of any date of determination shall mean those Employee Stockholders who Own a
majority of the total combined voting power of all Shares then held by the
Employee Stockholders.

     20.12. Mandatory Conversion. "Mandatory Conversion" shall have the meaning
ascribed to such term in the Restated Certificate.

     20.13. Other Shares. "Other Shares" shall mean Shares (including Shares
acquired pursuant to an Award) other than the SPA Shares.

     20.14. Owns, Own or Owned. "Owns," "Own," or "Owned" shall mean beneficial
ownership within the meaning of Rule 13d-3 under the Exchange Act, assuming the
conversion (whether or not then convertible) of all outstanding Preferred Stock
(which for purposes hereof shall mean assuming the conversion (whether or not
then convertible) of all outstanding Preferred Stock into the number of shares
of Common Stock into which such Preferred Stock is convertible at the then
applicable Conversion Rate in accordance with, and as adjusted from time to time
by, the Restated Certificate without giving effect to Article IV, Section 5,
subclauses (a)(i)(B)(2) and (a)(ii)(B)(2) of the Restated Certificate).

     20.15. Permitted Assignee. A "Permitted Assignee" shall mean, with respect
to each Investor, any Affiliate of such Investor and any member, general partner
or limited partner of such Investor (or any Person holding an equity interest in
any such member, general partner or limited partner); provided, that in each
instance, any such transferee agrees to be bound by the provisions of this
Agreement in accordance with the terms of Section 11.3 hereof.

     20.16. Person. "Person" shall mean an individual, partnership, corporation,
limited liability company, limited liability partnership, business trust, joint
stock company, trust, unincorporated association, joint venture, governmental
authority or other entity of whatever nature.

     20.17. Prime Rate. "Prime Rate" shall mean the rate from time to time
published in the "Money Rates" section of The Wall Street Journal as being the
"Prime Rate" (or, if more than one rate is published as the Prime Rate, then the
highest of such rates).

     20.18. Promissory Note. "Promissory Note" shall mean a promissory note in a
form reasonably acceptable to the Company with a maturity date that does not
exceed three (3) years from the date of such repurchase, bearing simple interest
of not less than the Prime Rate in effect on the date of such repurchase, and
payable as to interest in equal monthly installments during the term of the note
and as to principal on the maturity date.

                                       15

<PAGE>

     20.19. Qualified Public Offering. "Qualified Public Offering" shall have
the meaning ascribed to such term in the Restated Certificate.

     20.20. Registration Rights Agreement. "Registration Rights Agreement" shall
mean that certain Registration Rights Agreement, dated as of the date hereof, by
and among the Company and the investors ascribed thereto.

     20.21. Repurchase Price. "Repurchase Price" mean shall:

          (a) on or following an Employee Stockholder's termination of
     employment or service, as applicable, other than (i) by the Company or any
     Subsidiary for Cause (as defined in the Stock Incentive Plan) or (ii) in
     the event such Employee Stockholder materially violates any non-competition
     or similar restrictive covenant with the Company or any Subsidiary
     (including without limitation such restrictive covenants contained in an
     Employee Stockholder's employment agreement) prior to the date of
     repurchase, an amount equal to the Fair Market Value of the Shares on the
     date of repurchase;

          (b) on or following an Employee Stockholder's termination of
     employment or service, as applicable, by the Company or any Subsidiary for
     Cause (as defined in the Stock Incentive Plan), the lesser of (i) the
     original purchase price paid for such Shares, and (ii) the Fair Market
     Value of the Shares on the date of repurchase; or

          (c) in the event such Employee Stockholder materially violates any
     non-competition or similar restrictive covenant with the Company or any
     Subsidiary (including without limitation any such restrictive covenants
     contained in an Employee Stockholder's employment agreement) prior to the
     date of repurchase, the lesser of (i) the original purchase price paid for
     such Shares, and (ii) the Fair Market Value of the Shares on the date of
     repurchase.

     20.22. Requisite Institutional Investors. "Requisite Institutional
Investors" shall mean the Institutional Investors who Own a majority of the
total combined voting power of all Shares then held by the Institutional
Investors.

     20.23. Stock Incentive Plan. "Stock Incentive Plan" shall mean the Chronic
Care Solutions Holding, Inc. Stock Incentive Plan.

     20.24. Securities Act. "Securities Act" shall mean the Securities Act of
1933, as amended.

     20.25. Shares. "Shares" shall mean shares of Common Stock and Convertible
Securities (including Preferred Stock) convertible into Common Stock.

     20.26. SPA Shares. "SPA Shares" shall mean Shares acquired pursuant to the
Purchase Agreement.

     20.27. Transfer. "Transfer" (or any variation thereof used herein) shall
mean any direct or indirect sale, assignment, mortgage, transfer, pledge,
hypothecation or other disposal.

                                       16

<PAGE>

     20.28. Warburg Pincus. "Warburg Pincus" shall mean Warburg Pincus Private
Equity IX, L.P.

21. Grant of Irrevocable Proxy. Notwithstanding anything to the contrary in
Section 6, each Employee Stockholder hereby grants to Warburg Pincus such
Employee Stockholder's proxy, and appoints Warburg Pincus as such Employee
Stockholder's attorney-in-fact (with full power of substitution and
resubstitition), for and in its name, place and stead, to (i) vote or act by
written consent with respect to the Shares now or hereafter owned by such
Employee Stockholder (including the right to sign its name to any consent,
certificate or other document relating to the Company that Delaware law may
require) in connection with any and all matters, including, without limitation,
matters set forth hereunder as to which any vote or actions may be requested or
required (other than with respect to the consents required by Section 9 or 10
hereof), (ii) if requested by the underwriters managing any public offering of
securities of the Company, execute a lock-up agreement containing terms
consistent with those contained in any such lock-up agreement entered into by
the Institutional Investors with such underwriter and (iii) take any and all
action necessary to sell or otherwise Transfer such Employee Stockholder's
Shares as contemplated by Section 4 hereof. This proxy is coupled with an
interest and shall be irrevocable, and each Employee Stockholder will take such
further action or execute such other instruments as may be reasonably necessary
to effectuate the intent of this proxy and hereby revokes any proxy previously
granted by him with respect to his or her Shares.

                            [signature pages follow]

                                       17

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first above written.

                                        CHRONIC CARE SOLUTIONS HOLDING, INC.

                                        By: /s/ Alok Sanghvi
                                            ------------------------------------
                                        Name: Alok Sanghvi
                                        Title: President

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first above written.

                                        WARBURG PINCUS PRIVATE EQUITY IX, L.P.

                                        By: Warburg Pincus IX LLC, General
                                            Partner

                                        By: /s/ David Wenstrup
                                            ------------------------------------
                                        Name: David Wenstrup
                                        Title: Managing Director

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first set forth above.

                                        /s/ Howard Deutsch
                                        ----------------------------------------
                                        Name: Howard Deutsch
                                        Title: Executive Chairman

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first above written.

                                        /s/ Joseph Capper
                                        ----------------------------------------
                                        Name: Joseph Capper
                                        Title: Chief Executive Officer

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first set forth above.

                                        /s/ Ronald Drabik
                                        ----------------------------------------
                                        Name: Ronald Drabik
                                        Title: Chief Financial Officer

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first set forth above.

                                        /s/ Michael Geldart
                                        ----------------------------------------
                                        Name: Michael Geldart
                                        Title: Chief Operating Officer

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first set forth above.

                                        /s/ Daniel Wisniewski
                                        --------------------------------------
                                        Name: Daniel Wisniewski
                                        Title: Chief Information Officer

                    [Stockholders' Agreement Signature Page]

<PAGE>

     IN WITNESS WHEREOF, the undersigned has executed this Stockholders'
Agreement as of the date first set forth above.

                                        /s/ David Quick
                                        ----------------------------------------
                                        Name: David Quick
                                        Title: Executive Vice President,
                                               Sales and Marketing

                    [Stockholders' Agreement Signature Page]

<PAGE>

                                   SCHEDULE I

                             INSTITUTIONAL INVESTORS

WARBURG PINCUS PRIVATE EQUITY IX, L.P.
466 Lexington Avenue
New York, New York 10017
Facsimile No.: (212) 878-9100
Attention: David Wenstrup

with a copy to:

Willkie Farr & Gallagher LLP
787 Seventh Avenue
New York, New York 10019
Facsimile No.: (212) 728-9222
Attention: Steven J. Gartner, Esq.

<PAGE>

                                   SCHEDULE II

                              EMPLOYEE STOCKHOLDERS

HOWARD DEUTSCH
19 Tanglewood Drive
Titusville, NJ 08560

JOSEPH CAPPER
5139 Jasmine Way
Palm Harbor, FL 34685

RONALD DRABIK
915 Lumsden Reserve Drive
Brandon, FL 33511

MICHAEL GELDART
1407 Maple Forest Road
Clearwater, FL 33674

DANIEL WISNIEWSKI
2895 Armadillo Drive
Palm Harbor, FL 34683

DAVID QUICK
3902 First Street East
Palmetto, FL 34221

<PAGE>

                                    EXHIBIT A

                                     FORM OF

                                JOINDER AGREEMENT

     THIS JOINDER AGREEMENT (the "Agreement") is made as of the ____ day of
____________ by _________________, having an address at
____________________________ (the "Joining Party").

                                   WITNESSETH

     WHEREAS, Chronic Care Solutions Holding, Inc., a Delaware corporation (the
"Company"), is a party to that certain Stockholders' Agreement, dated as of
September 30, 2005 (as the same may be amended from time to time, the
"Stockholders' Agreement") (Capitalized terms used but not defined herein shall
have the meanings ascribed to them in the Stockholders' Agreement);

     WHEREAS, the Stockholders' Agreement provides that as a condition to
becoming an Investor, a Person must execute and deliver to the Company a Joinder
Agreement pursuant to which such Person agrees to be bound by the terms and
conditions of the Stockholders' Agreement;

     WHEREAS, the Joining Party desires to become an Employee Stockholder of the
Company by executing a copy of this Agreement; and

     WHEREAS, the Joining Party has determined that it is desirable and in the
Joining Party's best interests to execute this Joinder Agreement.

     NOW, THEREFORE, the Joining Party hereby agrees as follows:

     1. Joinder of Operating Agreement. By executing this Joinder Agreement, the
Joining Party accepts and agrees to be bound by all of the terms and provisions
of the Stockholders' Agreement as if he, she or it were an original signatory
thereto and shall be deemed to be, and entitled to all of the rights and subject
to all of the obligations of, an Employee Stockholder thereunder, such Joining
Party hereby acknowledges its grant of an irrevocable proxy pursuant to Section
21 of the Stockholders' Agreement and such Joining Party shall be added to
Schedule I of the Stockholders' Agreement.

     2. Full Force and Effect. Except as expressly modified by this Agreement,
all of the terms, covenants, agreements, conditions and other provisions of the
Stockholders' Agreement shall remain in full force and effect in accordance with
its terms.

     3. Notices. All notices provided to the Joining Party shall be sent or
delivered to the Joining Party at the address set forth on the signature page
hereto unless and until the Company and the Institutional Investor have received
written notice from the Joining Party of a changed address.

<PAGE>

     4. Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of Delaware applicable to contracts made
and to be performed entirely within such state.

                            [Signature page follows]

                                       -2-

<PAGE>

     IN WITNESS WHEREOF, the Joining Party has executed and delivered this
Agreement as of the date first above written.

                                        JOINING PARTY

                                        ----------------------------------------
                                        Name:
                                              ----------------------------------

                      [Signature Page to Joinder Agreement]<PAGE>

                                                                    EXHIBIT 10.2

                      CHRONIC CARE SOLUTIONS HOLDING, INC.

                          REGISTRATION RIGHTS AGREEMENT

          REGISTRATION RIGHTS AGREEMENT, dated as of September 30, 2005, among
the institutional investor(s) listed on Schedule I hereto (the "Institutional
Investors"), those employees listed on Schedule II hereto (the "Employee
Investors" and together with the Institutional Investors, the "Investors") and
Chronic Care Solutions Holding, Inc., a Delaware corporation (the "Company").

                                    RECITALS

          WHEREAS, the Investors have, pursuant to the terms of the Securities
Purchase Agreement, dated as of September 30, 2005, by and among the Company and
the Investors (the "Purchase Agreement"), agreed to purchase shares of Series A
Convertible Preferred Stock, par value $0.01 per share, of the Company (the
"Preferred Stock"); and

          WHEREAS, the shares of Preferred Stock are convertible into shares of
common stock, par value $0.01 per share, of the Company (the "Common Stock");
and

          WHEREAS, the Institutional Investors hold 10 shares of Common Stock;
and

          WHEREAS, the Company has agreed, as a condition precedent to the
Investors' obligations under the Purchase Agreement, to grant the Investors
certain Registration rights; and

          WHEREAS, the Company and the Investors desire to define the
Registration rights of the Investors on the terms and subject to the conditions
herein set forth.

          NOW, THEREFORE, in consideration of the foregoing premises and for
other good and valuable consideration, the parties hereby agree as follows:

     SECTION 1. DEFINITIONS

          As used in this Agreement, the following terms have the respective
meanings set forth below:

          Agreement: shall mean this Registration Rights Agreement among the
Investors and the Company;

          Commission: shall mean the Securities and Exchange Commission or any
other federal agency at the time administering the Securities Act;

          Exchange Act: shall mean the Securities Exchange Act of 1934, as
amended (or any successor act), and the rules and regulations promulgated
thereunder;

          Holder: shall mean any holder of Registrable Securities;

<PAGE>

          Initial Public Offering: shall mean the initial public offering of
shares of Common Stock pursuant to a Registration under the Securities Act;

          Initial Qualified Public Offering: shall mean the consummation of the
Company's initial Qualified Public Offering;

          QPO Registration: shall mean any Registration in connection with the
Initial Qualified Public Offering or any Registration prior to such Initial
Qualified Public Offering;

          Initiating Holder(s): shall mean the Institutional Investors who in
the aggregate are the Holders of more than 50% of all then outstanding
Registrable Securities held by the Institutional Investors;

          Person: shall mean an individual, partnership, joint-stock company,
corporation, limited liability company, trust or unincorporated organization,
and a government or agency or political subdivision thereof;

          Qualified Public Offering: shall have the meaning set forth in the
Restated Certificate;

          Register, Registered and Registration: shall mean a registration
effected by preparing and filing a registration statement in compliance with the
Securities Act (and any post-effective amendments filed or required to be filed)
and the declaration or ordering of effectiveness of such registration statement;

          Registrable Securities: shall mean (A) shares of Common Stock issuable
upon conversion of the shares of Preferred Stock, (B) any other shares of Common
Stock held or hereafter acquired by the Investors, including any shares of
Common Stock issuable upon exchangeable securities, and (C) any stock of the
Company issued as a dividend or other distribution with respect to, or in
exchange for or in replacement of, the shares of Preferred Stock or Common Stock
referred to in clause (A) or (B);

          Registration Expenses: shall mean all expenses incurred by the Company
in compliance with Section 2(a), (b) and (c) hereof, including, without
limitation, all registration and filing fees, printing expenses, fees and
disbursements of counsel for the Company, fees and expenses of one counsel for
all the Holders, which counsel shall be chosen by the Initiating Holder, blue
sky fees and expenses and the expense of any special audits incident to or
required by any such Registration (but excluding the compensation of regular
employees of the Company, which shall be paid in any event by the Company);

          Restated Certificate: shall have the meaning set forth in that certain
Stockholders' Agreement, dated as of the date hereof, by and among the Company
and the Investors;

          Security, Securities: shall have the meaning set forth in Section 2(1)
of the Securities Act;

          Securities Act: shall mean the Securities Act of 1933, as amended (or
any successor act), and the rules and regulations promulgated thereunder; and

                                      -2-

<PAGE>

          Selling Expenses: shall mean all underwriting discounts and selling
commissions applicable to the sale of Registrable Securities and all fees and
disbursements of counsel for each of the Holders other than fees and expenses of
one counsel.

     SECTION 2. REGISTRATION RIGHTS

          (a)  Requested Registration.

               (i) Request for Registration. If the Company shall receive a
     written request that the Company effect any Registration with respect to
     all or a part of the Registrable Securities from the Initiating Holder, (x)
     at any time prior to the Initial Qualified Public Offering or (y) at any
     time after 180 days after the Initial Qualified Public Offering, the
     Company will:

                    (1) promptly give written notice of the proposed
          Registration, qualification or compliance to all other Holders (other
          than the Employee Investors if in connection with any QPO
          Registration); and

                    (2) as soon as practicable, use its diligent best efforts to
          effect such Registration (including, without limitation, the execution
          of an undertaking to file post-effective amendments, appropriate
          qualification under applicable blue sky or other state securities laws
          and appropriate compliance with applicable regulations issued under
          the Securities Act) as may be so requested and as would permit or
          facilitate the sale and distribution of all or such portion of such
          Registrable Securities as are specified in such request, together with
          all or such portion of the Registrable Securities of any Holder or
          Holders (other than the Employee Investors if in connection with any
          QPO Registration) joining in such request as are specified in a
          written request received by the Company within ten (10) business days
          after written notice from the Company is given under Section
          2(a)(i)(1) above; provided that the Company shall not be obligated to
          effect, or take any action to effect:

                         (A) any such Registration pursuant to this Section 2(a)
               in any particular jurisdiction in which the Company would be
               required to execute a general consent to service of process in
               effecting such Registration, qualification or compliance, unless
               the Company is already subject to service in such jurisdiction
               and except as may be required by the Securities Act or applicable
               rules or regulations thereunder;

                         (B) any such Registration pursuant to clause (y) of
               this Section 2(a)(i), if the Company has effected two (2) such
               Registrations pursuant to requests under clause (y) of this
               Section 2(a)(i) and such Registrations have been declared or
               ordered effective and the sales of all such Registrable
               Securities requested to be so Registered shall have closed;

                         (C) any such Registration pursuant to this Section
               2(a), if the Registrable Securities requested by the Initiating
               Holder to be

                                      -3-

<PAGE>

               Registered pursuant to such request do not have an anticipated
               aggregate public offering price (before deduction of Selling
               Expenses) of at least $25,000,000;

                         (D) any such Registration pursuant to this Section 2(a)
               during the period starting with the date sixty (60) days prior to
               the Company's good faith estimate of the date of filing of, and
               ending on the date six (6) months immediately following the
               effective date of, any registration statement pertaining to
               securities of the Company (other than a Registration of
               securities in a Rule 145 transaction under the Securities Act,
               with respect to an employee benefit plan or with respect to the
               Initial Public Offering), provided that the Company is actively
               employing in good faith all reasonable efforts to cause such
               registration statement to become effective; provided, however,
               that the Company may only delay an offering pursuant to this
               Section 2(a)(i)(2)(D) for a period of not more than sixty (60)
               days, if a filing of any other registration statement is not made
               within that period and the Company may only exercise this right
               once in any twelve (12)-month period; or

                         (E) any such Registration pursuant to this Section
               2(a), if the Company shall furnish to the Initiating Holder a
               certificate signed by the President of the Company stating that
               in the good faith judgment of the Board of Directors of the
               Company it would be seriously detrimental to the Company or its
               stockholders for a registration statement to be filed in the near
               future, in which case the Company's obligation to use its
               diligent best efforts to comply with this Section 2(a) shall be
               deferred for a period not to exceed sixty (60) days from the date
               of receipt of the written request from such Initiating Holder;
               provided, however, that the Company shall not exercise such right
               more than once in any twelve (12)-month period.

          The registration statement filed pursuant to the request of the
Initiating Holder may, subject to the provisions of Section 2(a)(ii) below,
include other securities of the Company which are held by Persons who, by virtue
of agreements with the Company, are entitled to include their securities in any
such Registration ("Other Stockholders"). In the event that the Institutional
Investors request a Registration pursuant to this Section 2(a) in connection
with a distribution of Registrable Securities to its partners or members, the
Registration shall provide for the resale by such partners or members, if
requested by such Institutional Investors.

               (ii) Underwriting. If the Initiating Holder intends to distribute
     the Registrable Securities covered by its request (including, subject to
     the terms hereof, such Registrable Securities of any Holder joining such
     request pursuant to, and in accordance with, Section 2(a)(i)(2) hereof) by
     means of an underwriting, it shall so advise the Company as a part of its
     request made pursuant to Section 2(a)(i).

          If Other Stockholders request inclusion of their securities in the
underwriting, the Holders shall offer to include the securities of such Other
Stockholders in the underwriting and may condition such offer on their
acceptance of the further applicable provisions of this Section

                                      -4-

<PAGE>

2. The Holders whose shares of Common Stock are to be included in such
Registration and the Company shall (together with all Other Stockholders
proposing to distribute their securities through such underwriting) enter into
an underwriting agreement in customary form with the representative of the
underwriter or underwriters selected for such underwriting by the Initiating
Holder and reasonably acceptable to the Company; provided, however, that such
underwriting agreement shall not provide for indemnification or contribution
obligations on the part of the Holders materially greater than the obligations
of the Holders under Section 2(f)(ii). Notwithstanding any other provision of
this Section 2(a), if the representative advises the Holders in writing that
marketing factors require a limitation on the number of shares of Common Stock
to be underwritten, the securities of the Company held by Other Stockholders
shall be excluded from such Registration to the extent so required by such
limitation. If, after the exclusion of such shares, further reductions are still
required, the number of Registrable Securities included in the Registration by
each Holder shall be reduced on a pro rata basis (based on the number of shares
held by such Holder), by such minimum number of shares as is necessary to comply
with such request. No Registrable Securities or any other securities excluded
from the underwriting by reason of the underwriter's marketing limitation shall
be included in such Registration. If any Other Stockholder who has requested
inclusion in such Registration as provided above disapproves of the terms of the
underwriting, such Person may elect to withdraw therefrom by providing written
notice to the Company, the underwriter and the Initiating Holder. The securities
so withdrawn shall also be withdrawn from Registration. If the underwriter has
not limited the number of Registrable Securities or other securities to be
underwritten, the Company and officers and directors of the Company (to the
extent such Persons are not otherwise Holders) may include its or their
securities for its or their own account in such Registration if the
representative so agrees and if the number of Registrable Securities and other
securities which would otherwise have been included in such Registration and
underwriting will not thereby be limited.

          (b) Company Registration.

               (i) If the Company shall determine to Register any of its equity
     securities either for its own account or for the account of the
     Institutional Investors, any Holder or any Other Stockholder, other than a
     Registration relating solely to employee benefit plans, or a Registration
     relating solely to a Rule 145 transaction under the Securities Act, or a
     Registration on any registration form which does not permit secondary sales
     or does not include substantially the same information as would be required
     to be included in a registration statement covering the sale of Registrable
     Securities, the Company will:

                    (1) promptly give to each of the Holders (other than the
          Employee Investors if in connection with any QPO Registration) a
          written notice thereof (which notice shall include a list of the
          jurisdictions in which the Company intends to attempt to qualify such
          securities under the applicable blue sky or other state securities
          laws); and

                    (2) include in such Registration (and any related
          qualification under blue sky laws or other compliance), and in any
          underwriting involved therein, all the Registrable Securities (other
          than Registrable Securities held by

                                      -5-
<PAGE>

          the Employee Investors if in connection with any QPO Registration)
          specified in a written request or requests, made by the Holders within
          fifteen (15) days after receipt of the written notice from the Company
          described in clause (1) above, except as set forth in Section 2(b)(ii)
          below. Such written request may specify to include in such
          registration all or a part of the Holders' Registrable Securities. In
          the event any Holder requests inclusion in a Registration pursuant to
          this Section 2(b) in connection with a distribution of Registrable
          Securities to its partners or members, the Registration shall provide
          for the resale by such partners or members, if requested by such
          Holder.

               (ii) Underwriting. If the Registration of which the Company gives
     notice is for a Registered public offering involving an underwriting, the
     Company shall so advise each of the Holders (other than the Employee
     Investors if in connection with the Initial Qualified Public Offering or
     Registrations prior to such Initial Qualified Public Offering) as a part of
     the written notice given pursuant to Section 2(b)(i)(1) above. In such
     event, the right of each of the Holders (other than the Employee Investors
     if in connection with the Initial Qualified Public Offering or
     Registrations prior to such Initial Qualified Public Offering) to
     Registration pursuant to this Section 2(b) shall be conditioned upon such
     Holders' participation in such underwriting and the inclusion of such
     Holders' Registrable Securities in the underwriting to the extent provided
     herein. The Holders whose shares are to be included in such Registration
     shall (together with the Company and the Other Stockholders distributing
     their securities through such underwriting) enter into an underwriting
     agreement in customary form with the representative of the underwriter or
     underwriters selected for underwriting by the Company; provided, however,
     that such underwriting agreement shall not provide for indemnification or
     contribution obligations on the part of the Holders materially greater than
     the obligations of the Holders under Section 2(f)(ii). Notwithstanding any
     other provision of this Section 2(b), if the representative determines that
     marketing factors require a limitation on the number of shares to be
     underwritten, and (x) if such Registration is the Initial Public Offering,
     the representative may (subject to the allocation priority set forth below)
     exclude from such Registration and underwriting some or all of the
     Registrable Securities which would otherwise be underwritten pursuant
     hereto, and (y) if such Registration is other than the Initial Public
     Offering, the representative may (subject to the allocation priority set
     forth below) limit the number of Registrable Securities to be included in
     the Registration and underwriting to not less than twenty-five percent
     (25%) of the shares included therein (based on the number of shares). The
     Company shall so advise all Holders of securities requesting Registration,
     and the number of shares of securities that are entitled to be included in
     the Registration and underwriting shall be allocated in the following
     manner: The securities of the Company held by officers, directors and Other
     Stockholders of the Company (other than Registrable Securities and other
     than securities held by holders who by contractual right demanded such
     Registration ("Demanding Holders")) shall be excluded from such
     Registration and underwriting to the extent required by such limitation,
     and, if a limitation on the number of shares is still required, the number
     of shares that may be included in the Registration and underwriting by each
     of the Holders and Demanding Holders shall be reduced, on a pro rata basis
     (based on the number of shares held by such Holder or Demanding Holder), by
     such minimum number of shares as is necessary to

                                      -6-

<PAGE>

     comply with such limitation. If any of the Holders or any officer, director
     or Other Stockholder disapproves of the terms of any such underwriting, he,
     she or it may elect to withdraw therefrom by providing written notice to
     the Company and the underwriter. Any Registrable Securities or other
     securities excluded or withdrawn from such underwriting shall be withdrawn
     from such Registration.

          (c) Form S-3. Following the Initial Public Offering, the Company shall
use its best efforts to qualify for Registration on Form S-3 for secondary
sales. After the Company has qualified for the use of Form S-3, the Initiating
Holder shall have the right to request an unlimited number of Registrations on
Form S-3 (such requests shall be in writing and shall state the number of shares
of Registrable Securities to be disposed of and the intended method of
disposition of shares by such Initiating Holder), provided that the Company
shall not be obligated to effect, or take any action to effect, any such
Registration pursuant to this Section 2(c):

               (i) unless the Holders requesting Registration propose to dispose
     of shares of Registrable Securities having an aggregate price to the public
     (before deduction of Selling Expenses) of more than $10,000,000;

               (ii) within one hundred eighty (180) days of the effective date
     of the most recent Registration pursuant to this Section 2(c) in which
     securities held by the Initiating Holder could have been included for sale
     or distribution;

               (iii) in any particular jurisdiction in which the Company would
     be required to execute a general consent to service of process in effecting
     such Registration, qualification or compliance, unless the Company is
     already subject to service in such jurisdiction and except as may be
     required by the Securities Act or applicable rules or regulations
     thereunder;

               (iv) during the period starting with the date sixty (60) days
     prior to the Company's good faith estimate of the date of filing of, and
     ending on the date six (6) months immediately following the effective date
     of, any registration statement pertaining to securities of the Company
     (other than a Registration of securities in a Rule 145 transaction under
     the Securities Act or with respect to an employee benefit plan), provided
     that the Company is actively employing in good faith all reasonable efforts
     to cause such registration statement to become effective; provided,
     however, that the Company may only delay an offering pursuant to this
     Section 2(c)(iv) for a period of not more than sixty (60) days, if a filing
     of any other registration statement is not made within that period and the
     Company may only exercise this right once in any twelve (12)-month period;
     or

               (v) if the Company shall furnish to the Initiating Holder a
     certificate signed by the President of the Company stating that in the good
     faith judgment of the Board of Directors of the Company it would be
     seriously detrimental to the Company or its stockholders for a registration
     statement to be filed in the near future, in which case the Company's
     obligation to use its best efforts to comply with this Section 2(c) shall
     be deferred for a period not to exceed sixty (60) days from the date of
     receipt of a written

                                      -7-

<PAGE>

     request from the Initiating Holder; provided, however, that the Company
     shall not exercise such right more than once in any twelve (12)-month
     period.

          The Company shall give written notice to all Holders of the receipt of
a request for Registration pursuant to this Section 2(c) and shall provide a
reasonable opportunity for other Holders to participate in the Registration,
provided that if the Registration is for an underwritten offering, the terms of
Section 2(a)(ii) above shall apply to all participants in such offering. Subject
to the foregoing, the Company will use its best efforts to effect promptly the
Registration of all shares of Registrable Securities on Form S-3 to the extent
requested by the Initiating Holder holding such shares for purposes of
disposition. In the event the Initiating Holder requests a Registration pursuant
to this Section 2(c) in connection with a distribution of Registrable Securities
to its partners or members, the Registration shall provide for the resale by
such partners or members, if requested by such Initiating Holder.

          (d) Expenses of Registration. All Registration Expenses incurred in
connection with any Registration, qualification or compliance pursuant to this
Section 2 shall be borne by the Company, and all Selling Expenses shall be borne
by the Holders of the securities so Registered pro rata on the basis of the
number of their shares so Registered other than fees and expenses of counsel,
which, to the extent not included in Registration Expenses, shall be borne by
the Holder incurring such fees and expenses of counsel (or, if incurred by a
Holder or Holders on behalf of one or more other Holders, pro rata on the basis
of the number of their shares so Registered).

          (e) Registration Procedures. In the case of each Registration effected
by the Company pursuant to this Section 2, the Company will keep the Holders, as
applicable, advised in writing as to the initiation of each Registration and as
to the completion thereof. At its expense, the Company will:

               (i) keep such Registration effective for a period of one hundred
     twenty (120) days or until the Holders (or in the case of a distribution to
     the partners or members of such Holder, such partners or members), as
     applicable, have completed the distribution described in the registration
     statement relating thereto, whichever first occurs; provided, however, that
     (1) such one hundred twenty (120)-day period shall be extended for a period
     of time equal to the period during which the Holders, partners or members,
     as applicable, refrain from selling any securities included in such
     Registration in accordance with the provisions in Section 2(i) hereof; and
     (2) in the case of any Registration of Registrable Securities on Form S-3
     which are intended to be offered on a continuous or delayed basis, such one
     hundred and twenty (120)-day period shall be extended until all such
     Registrable Securities are sold, provided that Rule 415, or any successor
     rule under the Securities Act, permits an offering on a continuous or
     delayed basis; and provided further that applicable rules under the
     Securities Act governing the obligation to file a post-effective amendment
     permit, in lieu of filing a post-effective amendment which (x) includes any
     prospectus required by Section 10(a) of the Securities Act or (y) reflects
     facts or events representing a material or fundamental change in the
     information set forth in the registration statement, the incorporation by
     reference of information required to be included in (x) and (y) above to be
     contained in periodic

                                      -8-

<PAGE>

     reports filed pursuant to Section 12 or 15(d) of the Exchange Act in the
     registration statement;

               (ii) furnish such number of prospectuses and other documents
     incident thereto as each of the Holders, as applicable, from time to time
     may reasonably request;

               (iii) notify each Holder of Registrable Securities covered by
     such Registration at any time when a prospectus relating thereto is
     required to be delivered under the Securities Act of the happening of any
     event as a result of which the prospectus included in such registration
     statement, as then in effect, includes an untrue statement of a material
     fact or omits to state a material fact required to be stated therein or
     necessary to make the statements therein not misleading, in the light of
     the circumstances then existing; and

               (iv) furnish, on the date that such Registrable Securities are
     delivered to the underwriters for sale, if such securities are being sold
     through underwriters or, if such securities are not being sold through
     underwriters, on the date that the registration statement with respect to
     such securities becomes effective, (1) an opinion, dated as of such date,
     of the counsel representing the Company for the purposes of such
     Registration, in form and substance as is customarily given to underwriters
     in an underwritten public offering and reasonably satisfactory to a
     majority in interest of the Holders participating in such Registration,
     addressed to the underwriters, if any, and to the Holders participating in
     such Registration and (2) a letter, dated as of such date, from the
     independent certified public accountants of the Company, in form and
     substance as is customarily given by independent certified public
     accountants to underwriters in an underwritten public offering and
     reasonably satisfactory to a majority in interest of the Holders
     participating in such Registration, addressed to the underwriters, if any,
     and if permitted by applicable accounting standards, to the Holders
     participating in such Registration.

          (f) Indemnification.

               (i) The Company will indemnify each of the Holders, as
     applicable, each of its officers, directors, partners and members, and each
     Person controlling each of the Holders, with respect to each Registration
     which has been effected pursuant to this Section 2, and each underwriter,
     if any, and each Person who controls any underwriter, against all claims,
     losses, damages and liabilities (or actions in respect thereof) arising out
     of or based on any untrue statement (or alleged untrue statement) of a
     material fact contained in any prospectus, offering circular or other
     document (including any related registration statement, notification or the
     like) incident to any such Registration, qualification or compliance, or
     based on any omission (or alleged omission) to state therein a material
     fact required to be stated therein or necessary to make the statements
     therein not misleading, or any violation by the Company of the Securities
     Act or the Exchange Act or any rule or regulation thereunder applicable to
     the Company and relating to action or inaction required of the Company in
     connection with any such Registration, qualification or compliance, and
     will reimburse each of the Holders, each of its officers, directors,
     partners and members, and each Person controlling each of the

                                      -9-

<PAGE>

     Holders, each such underwriter and each Person who controls any such
     underwriter, for any legal and any other expenses reasonably incurred in
     connection with investigating and defending any such claim, loss, damage,
     liability or action, provided that the Company will not be liable in any
     such case to the extent that any such claim, loss, damage, liability or
     expense arises out of or is based on any untrue statement or omission based
     upon written information furnished to the Company by the Holders or
     underwriter and stated to be specifically for use therein.

               (ii) Each of the Holders will, if Registrable Securities held by
     it are included in the securities as to which such Registration,
     qualification or compliance is being effected, indemnify the Company, each
     of its directors and officers and each underwriter, if any, of the
     Company's securities covered by such a registration statement, each Person
     who controls the Company or such underwriter, each Other Stockholder and
     each of their respective officers, directors, partners and members, and
     each Person controlling such Other Stockholder against all claims, losses,
     damages and liabilities (or actions in respect thereof) arising out of or
     based on any untrue statement (or alleged untrue statement) of a material
     fact contained in any such registration statement, prospectus, offering
     circular or other document made by such Holder about such Holder, or any
     omission (or alleged omission) to state therein a material fact required to
     be stated therein or necessary to make the statements by such Holder about
     such Holder therein not misleading, and will reimburse the Company and such
     Other Stockholders, directors, officers, partners, members, Persons,
     underwriters or control Persons for any legal or any other expenses
     reasonably incurred in connection with investigating and defending any such
     claim, loss, damage, liability or action, in each case to the extent, but
     only to the extent, that such untrue statement (or alleged untrue
     statement) or omission (or alleged omission) is made in such registration
     statement, prospectus, offering circular or other document in reliance upon
     and in conformity with written information furnished to the Company by such
     Holder and stated to be specifically for use therein; provided, however,
     that the obligations of each of the Holders hereunder shall be limited to
     an amount equal to the net proceeds to such Holder of securities sold as
     contemplated herein.

               (iii) Each party entitled to indemnification under this Section
     2(f) (the "Indemnified Party") shall give notice to the party required to
     provide indemnification (the "Indemnifying Party") promptly after such
     Indemnified Party has actual knowledge of any claim as to which indemnity
     may be sought, and shall permit the Indemnifying Party to assume the
     defense of any such claim or any litigation resulting therefrom; provided
     that counsel for the Indemnifying Party, who shall conduct the defense of
     such claim or any litigation resulting therefrom, shall be approved by the
     Indemnified Party (whose approval shall not unreasonably be withheld) and
     the Indemnified Party may participate in such defense at such party's
     expense (unless the Indemnified Party shall have reasonably concluded that
     there may be a conflict of interest between the Indemnifying Party and the
     Indemnified Party in such action, in which case the fees and expenses of
     counsel shall be at the expense of the Indemnifying Party); and provided
     further that the failure of any Indemnified Party to give notice as
     provided herein shall not relieve the Indemnifying Party of its obligations
     under this Section 2(f) unless the Indemnifying Party is materially
     prejudiced thereby. No Indemnifying Party, in the defense of any such claim
     or litigation shall, except with the consent of each Indemnified

                                      -10-

<PAGE>

     Party, consent to entry of any judgment or enter into any settlement which
     does not include as an unconditional term thereof the giving by the
     claimant or plaintiff to such Indemnified Party of a release from all
     liability in respect to such claim or litigation. Each Indemnified Party
     shall furnish such information regarding itself or the claim in question as
     an Indemnifying Party may reasonably request in writing and as shall be
     reasonably required in connection with the defense of such claim and
     litigation resulting therefrom.

               (iv) If the indemnification provided for in this Section 2(f) is
     held by a court of competent jurisdiction to be unavailable to an
     Indemnified Party with respect to any loss, liability, claim, damage or
     expense referred to herein, then the Indemnifying Party, in lieu of
     indemnifying such Indemnified Party hereunder, shall contribute to the
     amount paid or payable by such Indemnified Party as a result of such loss,
     liability, claim, damage or expense in such proportion as is appropriate to
     reflect the relative fault of the Indemnifying Party on the one hand and of
     the Indemnified Party on the other in connection with the statements or
     omissions which resulted in such loss, liability, claim, damage or expense,
     as well as any other relevant equitable considerations. The relative fault
     of the Indemnifying Party and of the Indemnified Party shall be determined
     by reference to, among other things, whether the untrue (or alleged untrue)
     statement of a material fact or the omission (or alleged omission) to state
     a material fact relates to information supplied by the Indemnifying Party
     or by the Indemnified Party and the parties' relative intent, knowledge,
     access to information and opportunity to correct or prevent such statement
     or omission.

               (v) Notwithstanding the foregoing, to the extent that the
     provisions on indemnification and contribution contained in the
     underwriting agreement entered into in connection with any underwritten
     public offering contemplated by this Agreement are in conflict with the
     foregoing provisions, the provisions in such underwriting agreement shall
     be controlling.

               (vi) The foregoing indemnity agreement of the Company and Holders
     is subject to the condition that, insofar as they relate to any loss,
     claim, liability or damage arising out of a statement made in or omitted
     from a preliminary prospectus but eliminated or remedied in the amended
     prospectus on file with the Commission at the time the registration
     statement in question becomes effective or the amended prospectus filed
     with the Commission pursuant to Rule 424(b) under the Securities Act (the
     "Final Prospectus"), such indemnity or contribution agreement shall not
     inure to the benefit of any underwriter or Holder if a copy of the Final
     Prospectus was furnished to the underwriter and was not furnished to the
     Person asserting the loss, liability, claim or damage at or prior to the
     time such action is required by the Securities Act.

          (g) Information by the Holders.

               (i) Each of the Holders holding securities included in any
     Registration shall furnish to the Company such information regarding such
     Holder and the distribution proposed by such Holder as the Company may
     reasonably request in writing and as shall

                                      -11-

<PAGE>

     be reasonably required in connection with any Registration, qualification
     or compliance referred to in this Section 2.

               (ii) In the event that, either immediately prior to or subsequent
     to the effectiveness of any registration statement, any Holder shall
     distribute Registrable Securities to its partners or members, such Holder
     shall so advise the Company and provide such information as shall be
     necessary to permit an amendment to such registration statement to provide
     information with respect to such partners or members, as selling security
     holders. Promptly following receipt of such information, the Company shall
     file an appropriate amendment to such registration statement reflecting the
     information so provided. Any incremental expense to the Company resulting
     from such amendment shall be borne by such Holder.

          (h) Rule 144 Reporting.

          With a view to making available the benefits of certain rules and
regulations of the Commission which may permit the sale of restricted securities
to the public without Registration, the Company agrees to:

               (i) make and keep public information available as those terms are
     understood and defined in Rule 144 under the Securities Act ("Rule 144"),
     at all times from and after ninety (90) days following the effective date
     of the first Registration under the Securities Act filed by the Company for
     an offering of its securities to the general public;

               (ii) use its best efforts to file with the Commission in a timely
     manner all reports and other documents required of the Company under the
     Securities Act and the Exchange Act at any time after it has become subject
     to such reporting requirements; and

               (iii) so long as a Holder owns any Registrable Securities,
     furnish to such Holder upon request, a written statement by the Company as
     to its compliance with the reporting requirements of Rule 144 (at any time
     from and after ninety (90) days following the effective date of the first
     registration statement filed by the Company for an offering of its
     securities to the general public), and of the Securities Act and the
     Exchange Act (at any time after it has become subject to such reporting
     requirements), a copy of the most recent annual or quarterly report of the
     Company, and such other reports and documents so filed as such Holder may
     reasonably request in availing itself of any rule or regulation of the
     Commission allowing such Holder to sell any such securities without
     Registration.

          (i) "Market Stand-off" Agreement. Each of the Holders agrees, if
requested by the Company and an underwriter of equity securities of the Company,
not to sell or otherwise transfer or dispose of any Registrable Securities held
by such Holder during the one hundred eighty (180)-day period immediately
following the effective date of a registration statement of the Company filed
under the Securities Act or, if the Initiating Holder agrees to be subject to
such restriction for a period longer than such one hundred eighty (180)-day
period, such longer period; provided that:

                                      -12-

<PAGE>

               (i) such agreement only applies to the Initial Public Offering;
     and

               (ii) all officers and directors of the Company enter into similar
     agreements.

          If requested by the underwriters, the Holders shall execute a separate
agreement to the foregoing effect. The Company may impose stop-transfer
instructions with respect to the shares (or securities) subject to the foregoing
restriction until the end of said restricted period. The provisions of this
Section 2(i) shall be binding upon any transferee who acquires Registrable
Securities.

          (j) Additional Registration Rights. The Company shall not, without
first obtaining the written consent of the Holders who are Holders of more than
50% of the then outstanding Registrable Securities, grant future Registration
rights on terms more favorable than the Registration rights granted pursuant to
this Agreement.

          (k) Termination. The Registration rights set forth in this Section 2
shall not be available to any Holder if, (i) in the opinion of counsel to the
Company, all of the Registrable Securities then owned by such Holder could be
sold in any ninety (90)-day period pursuant to Rule 144 (without giving effect
to the provisions of Rule 144(k)) or (ii) all of the Registrable Securities held
by such Holder have been sold in a Registration pursuant to the Securities Act
or pursuant to Rule 144.

     SECTION 3. MISCELLANEOUS

          (a) Directly or Indirectly. Where any provision in this Agreement
refers to action to be taken by any Person, or which such Person is prohibited
from taking, such provision shall be applicable whether such action is taken
directly or indirectly by such Person.

          (b) Governing Law. This Agreement shall be governed by and construed
in accordance with the laws of the State of New York applicable to contracts
made and to be performed entirely within such State.

          (c) Section Headings. The headings of the sections and subsections of
this Agreement are inserted for convenience only and shall not be deemed to
constitute a part thereof.

          (d) Notices.

               (i) All notices, requests, demands, waivers and other
     communications required or permitted to be given under this Agreement shall
     be in writing and shall be deemed to have been duly given if (a) delivered
     personally, (b) mailed, certified or registered mail with postage prepaid,
     (c) sent by next-day or overnight mail or delivery or (d) sent by telecopy
     (including facsimile), as follows:

                    (1) if to the Company, to Chronic Care Solutions Holding,
          Inc. c/o Warburg Pincus Private Equity IX, L.P., 466 Lexington Avenue,
          New York, New York 10017, Attention: David Wenstrup (facsimile: (212)
          878-9100), or at such other address as it may have furnished in
          writing to the Company and

                                      -13-

<PAGE>

          Holders, with a copy to Willkie Farr & Gallagher LLP, 787 Seventh
          Avenue, New York, NY 10019, Attention: Steven J. Gartner, Esq.
          (facsimile: (212) 728-9222).

                    (2) if to the Institutional Investors or the Employee
          Investors, at the address or facsimile number listed on Schedule I or
          Schedule II, respectively, or at such other address or facsimile
          number as the Institutional Investors or the Employee Investors may
          have furnished in writing to the Company and the Holders.

               (ii) Any notice so addressed shall be deemed to be given: if
     delivered personally or by telecopy (including facsimile), on the date of
     such delivery, if a business day, otherwise on the first business day
     thereafter; if mailed by certified or registered mail with postage prepaid,
     on the third business day after the date of such mailing; and if sent by
     next-day or overnight mail or delivery, on the first business day following
     the date of such mailing or delivery.

          (e) Reproduction of Documents. This Agreement and all documents
relating hereto, including, without limitation, any consents, waivers and
modifications which may hereafter be executed may be reproduced by the Holders
by any photographic, photostatic, microfilm, microcard, miniature photographic
or other similar process and the Holders may destroy any original document so
reproduced. The parties hereto agree and stipulate that any such reproduction
shall be admissible in evidence as the original itself in any judicial or
administrative proceeding (whether or not the original is in existence and
whether or not such reproduction was made by the Holders in the regular course
of business) and that any enlargement, facsimile or further reproduction of such
reproduction shall likewise be admissible in evidence.

          (f) Successors and Assigns. This Agreement shall inure to the benefit
of and be binding upon the successors and assigns of each of the parties. The
registration rights set forth in Section 2 of this Agreement may be assigned, in
whole or in part, to any transferee of Registrable Securities (who shall be
bound by all obligations of this Agreement); provided, however, that no
transferee of Registrable Securities shall have any rights under this Agreement
unless (i) the transferee is expressly granted rights under this Agreement and
such rights are set forth in a writing executed by the transferor and the
Company and (ii) such transferee's Registrable Securities represent at least
five percent (5%) of the outstanding Common Stock on a fully-diluted basis.

          (g) Entire Agreement; Amendment and Waiver. This Agreement constitutes
the entire understanding of the parties hereto relating to the subject matter
hereof and supersedes all prior understandings among such parties. This
Agreement may be amended, and the observance of any term of this Agreement may
be waived, with (and only with) the written consent of the Company and the
Institutional Investors holding a majority of the then outstanding Registrable
Securities then held by the Institutional Investors.

          (h) Severability. In the event that any part or parts of this
Agreement shall be held illegal or unenforceable by any court or administrative
body of competent jurisdiction, such

                                      -14-

<PAGE>

determination shall not affect the remaining provisions of this Agreement which
shall remain in full force and effect.

          (i) Counterparts. This Agreement may be executed in two or more
counterparts (including by facsimile), each of which shall be deemed an original
and all of which together shall be considered one and the same agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -15-

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first above written.

                                        CHRONIC CARE SOLUTIONS HOLDING, INC.

                                        By: /s/ Alok Sanghvi
                                            ------------------------------------
                                        Name:  Alok Sanghvi
                                        Title: President

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first above written.

                                        WARBURG PINCUS PRIVATE EQUITY IX, L.P.

                                        By: Warburg Pincus IX LLC, General
                                            Partner

                                        By: /s/ David Wenstrup
                                            ------------------------------------
                                        Name:  David Wenstrup
                                        Title: Managing Director

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ Howard Deutsch
                                        ----------------------------------------
                                        Name: Howard Deutsch
                                        Title: Executive Chairman

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ Joseph Capper
                                        ----------------------------------------
                                        Name: Joseph Capper
                                        Title: Chief Executive Officer

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ Ronald Drabik
                                        -------------------------------------
                                        Name: Ronald Drabik
                                        Title: Chief Financial Officer

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ Michael Geldart
                                        ----------------------------------------
                                        Name: Michael Geldart

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ Daniel Wisniewski
                                        ----------------------------------------
                                        Name: Daniel Wisniewski

                 [Registration Rights Agreement Signature Page]

<PAGE>

          IN WITNESS WHEREOF, the undersigned has executed this Registration
Rights Agreement as of the date first set forth above.

                                        EMPLOYEE INVESTOR:

                                        /s/ David Quick
                                        ----------------------------------------
                                        Name: David Quick

                 [Registration Rights Agreement Signature Page]

<PAGE>

                                   Schedule I

                            "Institutional Investors"

INVESTOR NAME AND ADDRESS

Warburg Pincus Private Equity IX, L.P.
466 Lexington Avenue
New York, NY 10017
Facsimile: (212) 878-9100
Attention: David Wenstrup

with a copy to:

Willkie Farr & Gallagher LLP
787 Seventh Avenue
New York, NY 10019
Facsimile: (212) 728-9222
Attention: Steven J. Gartner, Esq.

<PAGE>

                                   Schedule II

                              "Employee Investors"

INVESTOR NAME AND ADDRESS

HOWARD DEUTSCH
19 Tanglewood Drive
Titusville, NJ 08560

JOSEPH CAPPER
5139 Jasmine Way
Palm Harbor, FL 34685

RONALD DRABIK
915 Lumsden Reserve Drive
Brandon, FL 33511

MICHAEL GELDART
1407 Maple Forest Road
Clearwater, FL 33674

DANIEL WISNIEWSKI
2895 Armadillo Drive
Palm Harbor, FL 34683

DAVID QUICK
3902 First Street East
Palmetto, FL 34221

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