Document:

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                                                                     EXHIBIT 4.3

                              PHARMION CORPORATION

                      SERIES C OMNIBUS AMENDMENT AGREEMENT

         This Series C Omnibus Amendment Agreement (the "Omnibus Agreement") is
made and entered into as of October 11, 2002 by and among Patrick Mahaffy and
Judith Hemberger (the "Founders"), Pharmion Corporation, a Delaware corporation
(the "Company"), the investors listed on Exhibit A hereto, each of which is
herein referred to as a "Series A Investor," the investors listed on Exhibit B
hereto, each of which is herein referred to as a "Series B Investor," the
investors listed on Exhibit C hereto, each of which is herein referred to as a
"Series C Investor" (together with the Series B Investors, the "Senior Preferred
Investors" and each such Series A Investor, Series B Investor and Series C
Investor further collectively being referred to as an "Investor"), who become
parties to this Agreement by executing and delivering a Financing Signature Page
(as defined in the Series C Purchase Agreement referred to below) and, solely
for the purposes of amending the Co-Sale Agreement (as defined below), the
individuals and entities listed on Exhibit C-1 hereto (each, an "Other
Stockholder" and collectively the "Other Stockholders").

                                    RECITALS

         In connection with the sale of the Series B Preferred Stock of the
Company (the "Series B Preferred Stock"), the Founders, the Company, the Series
A Investors and the Series B Investors entered into: (i) the Amended and
Restated Investors' Rights Agreement, dated as November 30, 2001 (the
"Investors' Rights Agreement"), (ii) the Amended and Restated Right of First
Refusal and Co-Sale Agreement, dated as of November 30, 2001 (the "Co-Sale
Agreement"), to which the Other Stockholders are additional parties thereto and
(iii) the Amended and Restated Voting Agreement, dated as of November 30, 2001
(the "Voting Agreement") (together, the "Series B Ancillary Agreements").

         The Company and the Series C Investors have entered into a Series C
Preferred Stock Purchase Agreement (the "Series C Purchase Agreement") of even
date herewith pursuant to which the Company desires to sell to the Series C
Investors, and the Series C Investors desire to purchase from the Company,
shares of the Company's Series C Preferred Stock (the "Series C Preferred Stock"
and, together with the Series B Preferred Stock, the "Senior Preferred Stock").
A condition to the Series C Investors' obligations under the Series C Purchase
Agreement is that the Founders, the Company, the Series A Investors, the Series
B Investors and the Series C Investors (and the Other Stockholders solely with
respect to amending the Co-Sale Agreement) enter into this Omnibus Agreement to
amend certain terms and conditions of each of the Series B Ancillary Agreements
in order to provide the Series C Investors with certain rights which are held by
the Series B Investors. The Founders, the Company, the Series A Investors and
the Series B Investors (and the Other Stockholders solely with respect to
amending the Co-Sale Agreement) each desire to induce the Series C Investors to
purchase shares of Series C Preferred Stock pursuant to the Series C Purchase
Agreement by entering into this Omnibus Agreement which amends each of the
Series B Ancillary Agreements as set forth herein.

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                                    AGREEMENT

         1.       AMENDMENT AND WAIVER OF THE INVESTORS' RIGHTS AGREEMENT.
Pursuant to the amendment and waiver provisions of the Investors' Rights
Agreement, the Company, the Founders, the holders of a majority of the Founders'
Stock, the holders of a majority of the Series A Registrable Securities and 55%
of the Series B Registrable Securities outstanding (as such terms are defined in
the Investors' Rights Agreement) hereby agree to amend the Investors' Rights
Agreement and waive certain rights as follows:

                  1.1.     DEFINITIONS. Section 1.1 of the Investors' Rights
         Agreement is hereby amended as follows:

                           (a)      By adding two new subclauses to the
         beginning of such section (further adjusting the lettering of the
         subsequent subclauses of such section accordingly) which will be and
         read as follows:

                                    "(a)     The term "Series C Preferred Stock"
                                    means the Company's Series C Preferred
                                    Stock; the term "Senior Preferred Stock"
                                    shall refer collectively to the Company's
                                    Series B Preferred Stock and Series C
                                    Preferred Stock; the term "Series C
                                    Investors" means investors in the Series C
                                    Preferred Stock, each of whom is listed on
                                    Exhibit C hereto; the term "Senior Preferred
                                    Investors" shall refer collectively to the
                                    Series B Investors and the Series C
                                    Investors; and the term "Series C Purchase
                                    Agreement" means the Series C Preferred
                                    Stock Purchase Agreement, dated October 11,
                                    2002, by and among the Company and the
                                    Series C Investors;

                                    (b)      Notwithstanding the definitions
                                    ascribed to such terms in the preamble and
                                    recitals to this Agreement, the following
                                    terms shall have the following meanings:
                                    "Preferred Stock" shall refer collectively
                                    to the Series A Preferred Stock, the Series
                                    B Preferred Stock and the Series C Preferred
                                    Stock; "Investor" shall refer to each of:
                                    (i) the Series A Investors, (ii) the Series
                                    B Investors and (iii) the Series C
                                    Investors;"

                           (b)      By amending and restating subclause (d)
         (formerly subclause (b)) of such section in its entirety as follows:

                                    "The term "Registrable Securities" means (i)
                                    the shares of Common Stock issuable or
                                    issued upon conversion of the Series A
                                    Preferred Stock and the Senior Preferred
                                    Stock, including any shares of Common Stock
                                    issuable or issued upon conversion of the
                                    Series B Preferred Stock issuable or issued
                                    to Celgene Corporation (together with its
                                    permitted successors and assigns, "Celgene")
                                    upon exercise of that certain Warrant to
                                    purchase shares of Series B Preferred Stock,
                                    (ii) the shares of Common Stock issued to
                                    the Founders (the "Founders' Stock"),
                                    provided, however, that for the

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                                    purposes of Section 1.2, 1.4 or 1.13 the
                                    Founders' Stock (other than any shares of
                                    Common Stock issued upon conversion of their
                                    shares of Series A Preferred Stock and
                                    Senior Preferred Stock held by them), shall
                                    not be deemed Registrable Securities and the
                                    Founders shall not be deemed Holders, and
                                    (iii) any other shares of Common Stock of
                                    the Company issued as (or issuable upon the
                                    conversion or exercise of any warrant, right
                                    or other security which is issued as) a
                                    dividend or other distribution with respect
                                    to, or in exchange for or in replacement of,
                                    the shares listed in (i) and (ii); provided,
                                    however, that the foregoing definition shall
                                    exclude in all cases any Registrable
                                    Securities sold by a person in a transaction
                                    in which his or her rights under this
                                    Agreement are not assigned. Notwithstanding
                                    the foregoing, Common Stock or other
                                    securities shall only be treated as
                                    Registrable Securities if and so long as
                                    they have not been (A) sold to or through a
                                    broker or dealer or underwriter in a public
                                    distribution or a public securities
                                    transaction, or (B) sold in a transaction
                                    exempt from the registration and prospectus
                                    delivery requirements of the Securities Act
                                    under Section 4(1) thereof so that all
                                    transfer restrictions, and restrictive
                                    legends with respect thereto, if any, are
                                    removed upon the consummation of such sale;"

                           (c)      By amending and restating subclause (e)
         (formerly subclause (c)) of such section in its entirety as follows:

                                    "The term "Series A Registrable Securities"
                                    means Registrable Securities consisting of
                                    Common Stock issuable or issued upon
                                    conversion of the Series A Preferred Stock,
                                    and the term "Senior Preferred Registrable
                                    Securities" means Registrable Securities
                                    consisting of Common Stock issuable or
                                    issued upon conversion of shares of Senior
                                    Preferred Stock;"

                  1.2.     AMENDMENT OF CERTAIN REFERENCES.

                           (a)      All references to the term "Series B
         Registrable Securities" in the Investors' Rights Agreement are hereby
         amended to be references to "Senior Preferred Registrable Securities."

                           (b)      The references in Sections 1.13 and 2.3(d)
         of the Investors' Rights Agreement to "Series B Preferred Stock" and
         "Purchase Agreement" are hereby amended to be references to "Series C
         Preferred Stock" and "Series C Purchase Agreement" respectively.

                           (c)      The reference in Section 3.3 of the
         Investors' Rights Agreement to "Series B Preferred Stock" is hereby
         amended to be a reference to "Senior Preferred Stock."

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                  1.3.     SELECTION OF UNDERWRITER. Section 1.5 of the
         Investors' Rights Agreement is hereby amended by adding a new subclause
         to the end of such section, which will be and read as follows:

                           "(j)     In the case of any public offering of equity
                           of the Company in which existing shareholders of the
                           Company are permitted to sell equity, the Company
                           will refrain from using a particular underwriter if
                           General Electric Pension Trust ("GEPT") provides the
                           Company with a written legal opinion, in form and
                           substance reasonably satisfactory to the Company,
                           concluding that the use of such underwriter in the
                           public offering would reasonably be expected to
                           result in a non-exempt prohibited transaction under
                           Section 406 of ERISA with respect to GEPT."

                  1.4.     WAIVER OF RIGHT OF FIRST OFFER UNDER THE INVESTORS'
         RIGHTS AGREEMENT. Section 2.3 of the Investors' Rights Agreement as to
         the right of first offer with respect to the sale of the shares of the
         Series C Preferred Stock pursuant to the Series C Purchase Agreement is
         hereby waived in its entirety, such waiver to be effective as of the
         date hereof and only with respect to such sale of Series C Preferred
         Stock.

                  1.5.     FIRPTA COVENANT. The Investors' Rights Agreement is
         hereby amended by adding a new clause after Section 2.4, identified as
         Section 2.5, which will be and read as follows:

                           "2.5     FIRPTA COVENANT. The Company shall provide
                           prompt notice to each Investor following any
                           "determination date" (as defined in Treasury
                           Regulation Section 1.897-2(c)(1)) on which the
                           Company becomes a United States real property holding
                           corporation. In addition, upon a written request by
                           any Investor, the Company shall provide such Investor
                           with a written statement informing such Investor
                           whether its interest in the Company constitutes a
                           United States real property interest. The Company's
                           determination shall comply with the requirements of
                           Treasury Regulation Section 1.897-2(h)(1) or any
                           successor regulation, and the Company shall provide
                           timely notice to the Internal Revenue Service, in
                           accordance with and to the extent required by
                           Treasury Regulation Section 1.897-2(h)(2) or any
                           successor regulation, that such statement has been
                           made. The Company's written statement to any request
                           by an Investor pursuant to this Section 2.5 shall be
                           delivered to such Investor within 10 days of such
                           Investor's written request therefor. The Company's
                           obligation to furnish such written statement shall
                           continue notwithstanding the fact that a class of the
                           Company's stock may be regularly traded on an
                           established securities market or the fact that there
                           is no preferred stock then outstanding."

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                  1.6.     SUBORDINATION OF CLAIMS. Section 3.2 of the
         Investors' Rights Agreement is hereby amended and restated in its
         entirety as follows:

                           "Series A Investors hereby agree that to the extent
                           they may have any claim against the Company for
                           breach of a representation or warranty in connection
                           with the purchase by them of the shares of Series A
                           Preferred Stock from the Company which is based on
                           facts similar to facts underlying a claim that the
                           Series B Investors and/or Series C Investors may have
                           against the Company for breach of a representation or
                           warranty by the Company in connection with the
                           purchase by the Series B Investors of the shares of
                           Series B Preferred Stock and/or the purchase by the
                           Series C Investors of the shares of Series C
                           Preferred Stock from the Company, all such rights
                           they may have with respect to any such claim shall be
                           subordinated to the rights of the Series B Investors
                           and/or Series C Investors."

                  1.7.     AMENDMENTS AND WAIVERS. Section 3.4 of the Investors'
         Rights Agreement is hereby amended and restated in its entirety as
         follows:

                           "Any term of this Agreement may be amended or waived
                           only with the written consent of the Company and the
                           holders of a majority of the Series A Registrable
                           Securities and 55% of the Senior Preferred
                           Registrable Securities then outstanding, not
                           including the Founders' Stock; provided that (a) if
                           such amendment has the effect of affecting the
                           Founders' Stock (i) in a manner different than
                           securities issued to the Investors and (ii) in a
                           manner adverse to the interests of the holders of the
                           Founders' Stock, then such amendment shall require
                           the consent of the holder or holders of a majority of
                           the Founders' Stock; or (b) if such amendment has the
                           effect of affecting holders of the Series C Preferred
                           Stock (i) in a manner different than the holders of
                           the Series B Preferred Stock and (ii) in a manner
                           adverse to the interests of the holders of the Series
                           C Preferred Stock, then such amendment shall require
                           the consent of the holders of at least eighty percent
                           (80%) of the then outstanding shares of the Series C
                           Preferred Stock. Any amendment or waiver effected in
                           accordance with this paragraph shall be binding upon
                           each party to the Agreement, whether or not such
                           party has signed such amendment or waiver, each
                           future holder of all such Registrable Securities, and
                           the Company. Notwithstanding the foregoing, this
                           Agreement may be further amended for Celgene to join
                           in, and be bound by, this Agreement as a holder of
                           Senior Preferred Registrable Securities hereunder,
                           whereupon the Company shall amend Exhibit B to
                           include Celgene and deliver the amended Exhibit B to
                           each Investor no later than ten (10) days after
                           Celgene becomes a party."

                  1.8.     ADDITION OF EXHIBIT. The Investors' Rights Agreement
         is hereby amended by adding thereto a new exhibit, identified as
         Exhibit C, which shall be the same as Exhibit C to this Omnibus
         Agreement.

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                  1.9.     ADDITION OF SERIES C INVESTORS AS PARTIES TO THE
         INVESTORS' RIGHTS AGREEMENT. By their signature to this Omnibus
         Agreement, each of the Series C Investors is hereby added as a party to
         the Investors' Rights Agreement, effective as of the date hereof.

         2.       AMENDMENT AND WAIVER OF THE CO-SALE AGREEMENT. Pursuant to the
amendment and waiver provisions of the Co-Sale Agreement, the Company, the
Founders (who are the Key Employees and holders of a majority of the Shares held
by the Key Employees), holders of a majority of the Series A Preferred Stock,
holders of 55% of the Series B Preferred Stock held by the Series B Investors
and a majority (by number of Shares held) of the Other Stockholders (as such
terms are defined in the Co-Sale Agreement) hereby agree to amend the Co-Sale
Agreement as follows:

                  2.1.     PREAMBLE AND RECITALS. The Preamble and Recitals to
         the Co-Sale Agreement are hereby amended and restated in their entirety
         as follows:

                           "This Amended and Restated Right of First Refusal and
                           Co-Sale Agreement (the "Agreement") is made and
                           entered into as of October 11, 2002 by and among
                           Patrick Mahaffy and Judith Hemberger (the
                           "Founders"), Pharmion Corporation, a Delaware
                           corporation (the "Company"), the investors listed on
                           Exhibit A hereto, each of which is herein referred to
                           as a "Series A Investor," the investors listed on
                           Exhibit B hereto, each of which is herein referred to
                           as a "Series B Investor," the investors listed on
                           Exhibit D hereto, each of which is herein referred to
                           as a "Series C Investor" (together with the Series B
                           Investors, the "Senior Preferred Investors" and each
                           such Series A Investor, Series B Investor and Series
                           C Investor further collectively being referred to as
                           an "Investor"), who become parties to this Agreement
                           by executing and delivering a Financing Signature
                           Page (as defined in the Purchase Agreement referred
                           to below); and the individuals or entities listed on
                           Exhibit C-1 hereto who become parties to this
                           Agreement by executing and delivering a signature
                           page substantially in the form of Exhibit C-2 hereto
                           (each, an "Other Stockholder" and collectively the
                           "Other Stockholders"); and the individuals listed on
                           Exhibit C-3 who become parties to this Agreement by
                           executing and delivering a signature page
                           substantially in the form of Exhibit C-4 hereto
                           (each, a "Key Employee" and collectively, with the
                           Founders, the "Key Employees"). The terms
                           "Stockholder" and "Stockholders" shall include,
                           individually or collectively, as the case may be, the
                           Investors, Other Stockholders and Key Employees.

                                                  RECITALS

                           The Founders, the Company and the Series A Investors
                           entered into a Right of First Refusal and Co-Sale
                           Agreement, dated January 5, 2000, in connection with
                           the sale of Series A-1 Preferred Stock and Series A-2
                           Preferred Stock of the Company (collectively, the
                           "Series A Preferred

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                           Stock") to the Series A Investors (the "Original
                           Agreement"). Pursuant to the Original Agreement, the
                           Founders granted to the Company, first, and then to
                           the Series A Investors, a right of first refusal on
                           any transfers of shares by either Founder. In the
                           event neither the Company nor the Series A Investors
                           exercised that right of first refusal, each of the
                           Series A Investors had the right to participate, on a
                           pro rata basis, with the Founder transferring his or
                           her shares.

                           The Founders, the Company, the Series A Investors,
                           the Series B Investors, the Other Stockholders and
                           the Key Employees entered into an Amended and
                           Restated Right of First Refusal and Co-Sale Agreement
                           (the "Amended Agreement"), dated as of November 30,
                           2001, in connection with the sale of Series B
                           Preferred Stock of the Company (the "Series B
                           Preferred Stock") to the Series B Investors, which
                           granted the Series B Investors certain "co-sale"
                           rights and provided the Series A Investors and Series
                           B Investors certain participation rights in
                           subsequent sales by all of the parties thereto of
                           shares of the Company's capital stock.

                           The Company and the Series C Investors have entered
                           into a Series C Preferred Stock Purchase Agreement
                           (the "Purchase Agreement") of even date herewith
                           pursuant to which the Company desires to sell to the
                           Series C Investors, and the Series C Investors desire
                           to purchase from the Company, shares of the Company's
                           Series C Preferred Stock (the "Series C Preferred
                           Stock" and, together with the Series B Preferred
                           Stock, the "Senior Preferred Stock"). A condition to
                           the Series C Investors' obligations under the Series
                           C Purchase Agreement is that the Company and the
                           Stockholders enter into this Agreement in order to
                           provide the Series C Investors with certain "co-sale"
                           rights and to provide all of the Investors the
                           opportunity to purchase and/or participate, upon the
                           terms and conditions set forth in this Agreement, in
                           subsequent sales by all of the parties hereto of
                           shares of the Company's capital stock.

                           Additionally, each of the parties to the Amended
                           Agreement desires to induce the Series C Investors to
                           purchase shares of Series C Preferred Stock pursuant
                           to the Purchase Agreement by entering into this
                           Agreement."

                  2.2.     NOTICE OF SALES; RIGHT OF FIRST REFUSAL.

                           (a)      All references to the term "Series B
         Preferred Stock" in Section 1.1 of the Co-Sale Agreement are hereby
         amended to be references to "Senior Preferred Stock."

                           (b)      The reference in the final sentence of
         Section 1.1 of the Co-Sale Agreement to the "Series B Investors" is
         hereby amended to be a reference to "Senior Preferred Investors."

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                  2.3.     CO-SALE RIGHTS. Section 1.2 of the Co-Sale Agreement
         is hereby amended and restated in its entirety as follows:

                           "If the Investor Rights of First Refusal are not
                           exercised in full by the Investors, each Senior
                           Preferred Investor shall have the right (the "Co-Sale
                           Right"), exercisable upon written notice to the
                           Company within fifteen (15) business days after the
                           Determination Notice Date to participate in such
                           Selling Stockholder's sale of Shares pursuant to the
                           specified terms and conditions of such Purchase
                           Offer. To the extent a Senior Preferred Investor
                           exercises such Co-Sale Right in accordance with the
                           terms and conditions set forth below, the number of
                           Offered Shares which such Selling Stockholder may
                           sell pursuant to such Purchase Offer shall be
                           correspondingly reduced. The Co-Sale Right of each
                           Senior Preferred Investor shall be subject to the
                           following terms and conditions:

                                    (a)      CALCULATION OF SHARES. Each Senior
                           Preferred Investor may sell all or any part of that
                           number of shares of Common Stock of the Company
                           issued or issuable upon conversion of shares of the
                           Senior Preferred Stock held by such Senior Preferred
                           Investor, or Common Stock received in connection with
                           any stock dividend, stock split or other
                           reclassification of shares of Senior Preferred Stock
                           and Common Stock issued upon conversion of shares of
                           Senior Preferred Stock (the "Senior Preferred
                           Conversion Shares") equal to the product obtained by
                           multiplying (i) the aggregate number of Offered
                           Shares covered by the Purchase Offer by (ii) a
                           fraction, the numerator of which is the number of
                           Senior Preferred Conversion Shares at the time owned
                           by such Senior Preferred Investor and the denominator
                           of which is the sum of (A) the total number of Senior
                           Preferred Conversion Shares at the time owned by all
                           Senior Preferred Investors participating in such sale
                           plus (B) the total number of Shares at the time owned
                           by such Selling Stockholder, including shares
                           transferred by such Selling Stockholder to Permitted
                           Transferees (as defined below) in accordance with
                           this Agreement.

                                    (b)      DELIVERY OF CERTIFICATES. Each
                           Senior Preferred Investor may effect its
                           participation in the sale by delivering to the
                           Selling Stockholder for transfer to the prospective
                           purchaser one or more certificates, properly endorsed
                           for transfer, which represent the Senior Preferred
                           Conversion Shares which such Senior Preferred
                           Investor elects to sell."

                  2.4.     TRANSFER. Section 1.3 of the Co-Sale Agreement is
         hereby amended and restated in its entirety as follows:

                           "The stock certificate or certificates which a Senior
                           Preferred Investor delivers to the Selling
                           Stockholder pursuant to Section 1.2 shall be
                           delivered by such Selling Stockholder to the
                           prospective purchaser in consummation of the sale
                           pursuant to the terms and conditions specified in

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                           the Notice, and such Selling Stockholder shall
                           promptly thereafter remit to such Senior Preferred
                           Investor that portion of the sale proceeds to which
                           such Senior Preferred Investor is entitled by reason
                           of its participation in such sale. To the extent that
                           any prospective purchaser or purchasers prohibits
                           such assignment or otherwise refuses to purchase
                           Senior Preferred Conversion Shares from a Senior
                           Preferred Investor exercising its Co-Sale Right
                           hereunder, the Selling Stockholder shall not sell to
                           such prospective purchaser or purchasers any Shares
                           unless and until, simultaneously with such sale, the
                           Selling Stockholder shall purchase such Senior
                           Preferred Conversion Shares from such Senior
                           Preferred Investor for the same consideration and on
                           the same terms and conditions as the proposed
                           transfer described in the Notice (which terms and
                           conditions shall be no less favorable than those
                           governing the sale to the purchaser by the Selling
                           Stockholder)."

                  2.5.     PERMITTED TRANSACTIONS. Section 1.5 of the Co-Sale
         Agreement is hereby amended and restated in its entirety as follows:

                           "The provisions of Section 1 of this Agreement shall
                           not pertain or apply to any transfer (i) to a
                           Stockholder's ancestors, descendants or spouse or to
                           a trust for their benefit; (ii) to an affiliate (as
                           such term is defined under the Securities Act of
                           1933, as amended (the "Securities Act")) of a
                           Stockholder (in the case of a Stockholder that is an
                           entity) or, if such investor is an investment fund,
                           to an investment fund under common management; (iii)
                           to a successor trustee or successor fiduciary (in the
                           case of a Stockholder that is an employee benefit
                           plan); or (iv) to a partner, a retired partner,
                           member or retired member or shareholder of a
                           Stockholder, or to the estate of any such partner or
                           member or shareholder (in the case of a Stockholder
                           that is a partnership or limited liability company or
                           corporation), provided, that (i) the Stockholder(s)
                           shall inform the Company and the Investors of any
                           such transfer prior to effecting it, and (ii) the
                           transferee (each a "Permitted Transferee") shall
                           furnish the Company and the Investors with a written
                           agreement to be bound by and comply with all
                           provisions of this Agreement applicable to the
                           transferring Stockholder."

                  2.6.     DRAG-ALONG RIGHT. Section 1.7 of the Co-Sale
         Agreement is hereby amended as follows:

                           (a)      By deleting the last sentence of Section
         1.7(a) and replacing it with the following:

                           "For purposes of this Agreement, "Drag-Along Holders"
                           shall mean (i) from the date of this Agreement
                           through the second anniversary of this Agreement (the
                           "Second Anniversary"), Investors holding a majority
                           of the then outstanding shares of Series A Preferred
                           Stock and 55% of the Senior Preferred Stock (treating
                           them on an as converted basis and as

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                           separate classes) and (ii) after the Second
                           Anniversary, shall mean Investors holding a majority
                           of the then outstanding shares of Series A Preferred
                           Stock and Senior Preferred Stock (treating them on an
                           as converted basis and as a single class)."

                           (b)      By adding a new subclause to the end of such
         section, which will be and read as follows:

                           "(e)     Notwithstanding anything to the contrary
                           herein, no Stockholder that is subject to Title I of
                           the Employee Retirement Income Security Act of 1974,
                           as amended ("ERISA"), shall be required to sell his
                           or its Shares if there is a reasonable likelihood
                           that such sale would constitute a non-exempt
                           prohibited transaction under Section 406 of ERISA,
                           provided that such stockholder shall have availed
                           itself of any applicable prohibited transaction class
                           exemptions."

                  2.7.     AMENDMENT OF CERTAIN REFERENCES. The references in
         Section 2.1 of the Co-Sale Agreement to "Series B Preferred Stock" are
         hereby amended to be references to "Senior Preferred Stock."

                  2.8.     AMENDMENTS AND WAIVERS. Section 4.2 of the Co-Sale
         Agreement is hereby amended and restated in its entirety as follows:

                           "Any term of this Agreement may be amended or waived
                           only with the written consent of the Company, the Key
                           Employees holding at least a majority of the Shares
                           held by all Key Employees, holders of at least a
                           majority of the Series A Preferred Stock and holders
                           of at least 55% of the Senior Preferred Stock held by
                           the Senior Preferred Investors. Any amendment or
                           waiver effected in accordance with this Section 4.2
                           shall be binding upon the Company and the
                           Stockholders and each of their respective successors
                           and assigns; provided that no such amendment shall be
                           effective (a) with respect to the Other Stockholders
                           that purports to alter any obligations of the Other
                           Stockholders hereunder without the written consent of
                           a majority (by number of Shares held) of the Other
                           Stockholders, or (b) with respect to the holders of
                           the Series C Preferred Stock if such amendment has
                           the effect of affecting the holders of the Series C
                           Preferred Stock (i) in a manner different than the
                           holders of the Series B Preferred Stock and (ii) in a
                           manner adverse to the interests of the holders of the
                           Series C Preferred Stock without the written consent
                           of the holders of at least eighty percent (80%) of
                           the then outstanding shares of the Series C Preferred
                           Stock. Notwithstanding the foregoing, Exhibit C-1 and
                           Exhibit C-3 may be amended by the Company solely to
                           add new parties as Other Stockholders and/or Key
                           Employees, as the case may be, without the consent of
                           any other party hereto, and in each such case, the
                           Company shall promptly notify each other party hereto
                           with respect to the addition of such new party or
                           parties and the number and types of Shares held by
                           such new party or parties."

                                       10

<PAGE>

                  2.9.     OTHER STOCKHOLDER AND KEY EMPLOYEE SIGNATURE PAGES.
         The first sentence of the first paragraph of the "Other Stockholder"
         Signature Page and the "Key Employee" Signature Page, as set forth on
         Exhibit C-2 and Exhibit C-4, respectively, to the Co-Sale Agreement, is
         hereby amended in its entirety to read as follows:

                           "By execution and delivery of this signature page,
                           the undersigned hereby agrees to become an [Other
                           Stockholder/Key Employee (as applicable)], as defined
                           in that certain Amended and Restated Right of First
                           Refusal and Co-Sale Agreement by and among Pharmion
                           Corporation, a Delaware corporation (the "Company"),
                           the Founders, the Investors, the Other Stockholders
                           and the Key Employees (as defined therein), dated as
                           of October 11, 2002, and as may have otherwise been
                           amended prior to the date hereof (as amended, the
                           "Co-Sale Agreement")."

                  2.10.    ADDITION OF EXHIBIT. The Co-Sale Agreement is hereby
         amended by adding thereto a new exhibit, identified as Exhibit D, which
         shall be the same as Exhibit C to this Omnibus Agreement.

                  2.11.    ADDITION OF SERIES C INVESTORS AS PARTIES TO THE
         CO-SALE AGREEMENT. By their signature to this Omnibus Agreement, each
         of the Series C Investors is hereby added as a party to the Co-Sale
         Agreement, effective as of the date hereof.

         3.       AMENDMENT AND WAIVER OF THE VOTING AGREEMENT. Pursuant to the
amendment and waiver provisions of the Voting Agreement, the Company, the
Founders, holders of a majority of the Series A Preferred Stock, holders of 55%
of the Series B Preferred Stock, Nomura International plc ("Nomura"), ProQuest
Investments II, L.P. ("ProQuest") and New Enterprise Associates 10, Limited
Partnership ("NEA") hereby agree to amend the Voting Agreement as follows:

                  3.1.     PREAMBLE AND RECITALS. The Preamble and Recitals to
         the Voting Agreement are hereby amended and restated in their entirety
         as follows:

                           "This Amended and Restated Voting Agreement (the
                           "Agreement") is made as of the 11th day of October
                           2002, by and among Pharmion Corporation, a Delaware
                           corporation (the "Company"), Patrick Mahaffy and
                           Judith Hemberger (the "Founders"), the investors
                           listed on Exhibit A hereto, each of which is herein
                           referred to as a "Series A Investor," the investors
                           listed on Exhibit B hereto, each of which is herein
                           referred to as a "Series B Investor," the investors
                           listed on Exhibit C hereto, each of which is herein
                           referred to as a "Series C Investor" (together with
                           the Series B Investors, the "Senior Preferred
                           Investors" and each such Series A Investor, Series B
                           Investor and Series C Investor further collectively
                           being referred to as an "Investor"), who become
                           parties to this Agreement by executing and delivering
                           a Financing Signature Page (as defined in the
                           Purchase Agreement referred to below).

                                       11

<PAGE>

                                                RECITALS

                           The Company, the Founders and the Series A Investors
                           entered into a Voting Agreement, dated January 5,
                           2000, in connection with the sale of Series A-1
                           Preferred Stock and Series A-2 Preferred Stock of the
                           Company (collectively, the "Series A Preferred
                           Stock") to the Series A Investors (the "Original
                           Agreement").

                           The Company, the Founders, the Series A Investors and
                           the Series B Investors entered into an Amended and
                           Restated Voting Agreement (the "Amended Agreement"),
                           dated as of November 30, 2001, in connection with the
                           sale of Series B Preferred Stock of the Company (the
                           "Series B Preferred Stock") to the Series B
                           Investors. In accordance with the Amended Agreement,
                           the Board of Directors of the Company presently
                           consists of two (2) Directors designated by the
                           Series A Investors, two (2) Directors designated by
                           the Founders, three (3) Directors designated by the
                           Series B Investors and one (1) non-employee Director.

                           The Company and the Series C Investors have entered
                           into a Series C Preferred Stock Purchase Agreement
                           (the "Purchase Agreement") dated as of even date
                           hereof pursuant to which the Company desires to sell
                           to the Series C Investors, and the Series C Investors
                           desire to purchase from the Company, shares of the
                           Company's Series C Preferred Stock (the "Series C
                           Preferred Stock" and, together with the Series B
                           Preferred Stock, the "Senior Preferred Stock"). A
                           condition to the Series C Investors' obligations
                           under the Purchase Agreement is that the Company, the
                           Founders and the Investors enter into this Agreement
                           for the purpose of maintaining the present structure
                           of the Board of Directors of the Company. The
                           Company, the Series A Investors and the Series B
                           Investors each desire to induce the Series C
                           Investors to purchase shares of Series C Preferred
                           Stock pursuant to the Purchase Agreement by agreeing
                           to enter into this Agreement."

                  3.2.     DEFINITION OF PARTIES. The definition of the
         "Parties" in Section 1.1 of the Voting Agreement is hereby amended to
         further include the Series C Investors.

                  3.3.     AMENDMENT OF CERTAIN REFERENCES. The references in
         Sections 1.2, 3.1(c) and 4.2 of the Voting Agreement to the "Series B
         Preferred Stock" are hereby amended to be references to "Senior
         Preferred Stock."

                  3.4.     ADDITION OF EXHIBIT. The Voting Agreement is hereby
         amended by adding thereto a new exhibit, identified as Exhibit C, which
         shall be the same as Exhibit C to this Omnibus Agreement.

                  3.5.     ADDITION OF SERIES C INVESTORS AS PARTIES TO THE
         VOTING AGREEMENT. By their signature to this Omnibus Agreement, each of
         the Series C Investors is hereby added as a party to the Voting
         Agreement, effective as of the date hereof.

                                       12

<PAGE>

         4.       MISCELLANEOUS.

                  4.1.     SEVERABILITY. If one or more provisions of this
         Omnibus Agreement are held to be unenforceable under applicable law,
         the parties agree to renegotiate such provision in good faith. In the
         event that the parties cannot reach a mutually agreeable and
         enforceable replacement for such provision, then (a) such provision
         shall be excluded from this Omnibus Agreement, (b) the balance of the
         Omnibus Agreement shall be interpreted as if such provision were so
         excluded and (c) the balance of the Omnibus Agreement shall be
         enforceable in accordance with its terms.

                  4.2.     GOVERNING LAW. This Omnibus Agreement and all acts
         and transactions pursuant hereto and the rights and obligations of the
         parties hereto shall be governed, construed and interpreted in
         accordance with the laws of the State of Delaware, without giving
         effect to principles of conflicts of law.

                  4.3.     COUNTERPARTS. This Omnibus Agreement may be executed
         in any number of counterparts, each of which shall be deemed an
         original and all of which together shall constitute one and the same
         instrument. The signature by a stockholder of the Company executing
         this Omnibus Agreement shall be deemed the signature of such person in
         his, her or its capacity as the holder of all such shares of capital
         stock of the Company held by such person on the date hereof. This
         Omnibus Agreement may be signed by facsimile signatures.

                  4.4.     TITLES AND SUBTITLES. The titles and subtitles used
         in this Omnibus Agreement are used for convenience only and are not to
         be considered in construing or interpreting this Omnibus Agreement.

                  4.5.     EFFECTIVENESS OF AGREEMENT. This Omnibus Agreement
         shall become effective when signed by the Company, the Founders, the
         holders of a majority of the Series A Preferred Stock, the holders of
         55% of the Series B Preferred Stock, Nomura, ProQuest, NEA and the
         Series C Investors holding shares of Series C Preferred Stock on the
         date first recited above.

                            [Signature Pages Follow]

                                       13

<PAGE>

         The parties have executed this Omnibus Agreement as of the date first
written above.

                                        COMPANY:

                                        PHARMION CORPORATION

                                        By: /s/ Patrick J. Mahaffy
                                            -----------------------
                                        Name: /s? Patrick J. Mahaffy
                                        ----------------------------
                                        Title: President & CEO

                                        Address: 2525 28th Street
                                                 Boulder, Colorado 80301

                                        Fax Number: (303) 449-0569

                                        FOUNDERS:

                                        /s/ Patrick J. Mahaffy
                                        ----------------------------------------
                                        Patrick J. Mahaffy

                                        Address: 2525 28th Street
                                                 Boulder, Colorado 80301

                                        Fax Number: (303) 449-0569

                                        /s/ Judith A. Hemberger
                                        ----------------------------------------
                                        Judith A. Hemberger

                                        Address: 2525 28th Street
                                                 Boulder, Colorado 80301

                                        Fax Number: (303) 449-0569

<PAGE>

                                        INVESTORS:

                                        VERSANT VENTURE CAPITAL I, L.P.

                                        By: Versant Ventures I, LLC

                                        By: /s/ Brian Atwood
                                            ------------------------------------

                                        Name: Brian Atwood
                                                      (print)
                                        Title: Managing Director

                                        Address: 3000 Sand Hill Road
                                                 BLDG. 1 - Suite 260
                                                 Menlo Park, CA 94025

                                        VERSANT SIDE FUND I, L.P.

                                        By: Versant Ventures I, LLC

                                        By: /s/ Brian Atwood
                                            ------------------------------------

                                        Name:  Brian Atwood
                                                       (print)
                                        Title: Managing Director

                                        Address: 3000 Sand Hill Road
                                                 BLDG. 1 - Suite 260
                                                 Menlo Park, CA 94025

                                        VERSANT AFFILIATES FUND 1-A, L.P.

                                        By: /s/ Brian Atwood
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Brian Atwood
                                                      (print)
                                        Title: Managing Director

                                        Address: 3000 Sand Hill Road
                                                 BLDG. 1 - Suite 260
                                                 Menlo Park, CA 94025

<PAGE>

                                        VERSANT AFFILIATES FUND 1-B, L.P.

                                        By: /s/ Brian Atwood
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Brian Atwood
                                                 (print)
                                        Title: Managing Director

                                        Address: 3000 Sand Hill Road
                                                 BLDG. 1 - Suite 260
                                                 Menlo Park, CA 94025

                                        DOMAIN PARTNERS IV, L.P.

                                        By: One Palmer Square Associates IV,
                                            L.L.C., its General Partner

                                        By: /s/ James C. Blair
                                            ------------------------------------
                                                James C. Blair

                                        Title: Managing Member

                                        Address: One Palmer Square
                                                 Princeton, NJ 08542

                                        DP IV ASSOCIATES, L.P.

                                        By: One Palmer Square Associates IV,
                                            L.L.C., its General Partner

                                        By: /s/ James C. Blair
                                            ------------------------------------
                                                James C. Blair

                                        Title: Managing Member

                                        Address: One Palmer Square
                                                 Princeton, NJ 08542

<PAGE>

                                        DOMAIN ASSOCIATES, L.L.C.

                                        By: /s/ James C. Blair
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: James C. Blair
                                                        (print)
                                        Title: Managing Member

                                        Address:

                                        ABERDARE VENTURES, L.P.

                                        By: Aberdare GP, L.L.C., its General
                                            Partner

                                        By: /s/ Paul H. Klingenstein
                                            ------------------------------------
                                                Paul H. Klingenstein

                                        Title: Managing Partner

                                        Address: One Embarcadero Center, #4000
                                                 San Francisco, CA
                                                 94111

                                        ABINGWORTH BIOVENTURES II
                                        SICAV

                                        By: /s/ Genevieve BLAUEN
                                            ------------------------------------

                                        By: /s/ Gerard MULLER
                                            ------------------------------------

                                        Name: Genevieve BLAUEN
                                              -----------------
                                              /s/ Gerard MULLER
                                                        (print)
                                        Title: Company Secretary Mandatory

                                        Address: 231 Val Des Bous Malade
                                                 Kirchberg - 2121
                                                 LUXEMBOURG

<PAGE>

                                        ROGER G. KENNEDY

                                        /s/ Roger G. Kennedy
                                        ----------------------------------------

                                        Address: 855 El Caminito
                                                 Santa Fe, New Mexico 87505

                                        TECHNOGEN ENTERPRISES LLC

                                        By: /s/ Isaac Stein
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Isaac Stein
                                                         (print)
                                        Title: Member

                                        Address: P.O. Box 2088
                                                 Menlo Park, CA 94026

                                        JAMES C. YOUNG

                                        /s/ James C. Young
                                        ----------------------------------------

                                        Address: 118 East Platte Avenue
                                                 Colorado Springs, CO 80903

                                        ANN YOUNG

                                        /s/ Ann H. Young
                                        ----------------------------------------

                                        Address: 118 East Platte Avenue
                                                 Colorado Springs, CO 80903

                                        CAM GARNER

                                        /s/ Cam Garner
                                        ----------------------------------------

                                        Address: 6363 Greenwich Dr.
                                                 San Diego, CA 92122

<PAGE>

                                        PETER H. JAKES and KAREN S. JAKES

                                        /s/ Peter H. Jakes  /s/ Karen S. Jakes
                                        ----------------------------------------

                                        Address: 520 East 86th Street, Apt 13-C
                                                 13-C New York, New York 10028

                                        ORRICK, HERRINGTON & SUTCLIFFE LLP

                                        By: /s/ Peter Cohn
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Peter Cohn
                                                       (print)
                                        Title: Partner

                                        Address: 1020 Marsh Road
                                                 Menlo Park, CA 94025

                                        PETER COHN, AS TRUSTEE, OR THE
                                        SUCCESSOR TRUSTEE OR TRUSTEES,
                                        U/A/D, DATED AUGUST 29, 1995, AS
                                        AMENDED, CREATING THE PETER COHN
                                        REVOCABLE TRUST.

                                        /s/ Peter Cohn
                                        ----------------------------------------
                                        Peter Cohn, Trustee

<PAGE>

                                        NOMURA INTERNATIONAL PLC

                                        By: /s/ Denise Pollard-Knight
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Denise Pollard-Knight
                                                        (print)
                                        Title: Head of Healthcare Private
                                               Equity

                                        Address:

                                        PROQUEST INVESTMENTS II, L.P.

                                        By: /s/ Pasquale DeAngelis
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Pasquale DeAngelis
                                                        (print)
                                        Title: Chief Financial Officer

                                        Address: 600 Alexander Park, Suite
                                                 204 Princeton, NJ 08540

                                        PROQUEST INVESTMENTS II
                                        ADVISORS FUND, L.P.

                                        By: /s/ Pasquale DeAngelis
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Pasquale DeAngelis
                                                        (print)
                                        Title:  Chief Financial Officer

                                        Address: 600 Alexander Park, Suite
                                                 204 Princeton, NJ 08540

<PAGE>

                                        BAY CITY CAPITAL FUND III, L.P.

                                        By: Bay City Capital Management III,
                                            LLC

                                        By: /s/ Sandy Zweifach
                                            ------------------------------------

                                        Name: Sandy Zweifach
                                                      (print)
                                        Title: Manager & Managing Director

                                        Address: 750 Battery St., Suite 600
                                                 San Francisco, CA 94111

                                        NEOMED INNOVATION III, L.P.

                                        By: Neomed Innovation III Limited,
                                            its General Partner

                                        By: /s/ Simon Christopher Young
                                            ------------------------------------

                                        Name: Simon Christopher Young
                                                      (print)
                                        Title: Director

                                        Address: P.O. Box 539, No. 1
                                                 WesleyStreet St. Helier,
                                                 Jersey L.I. JE4 SUT

<PAGE>

                                        NEW ENTERPRISE ASSOCIATES 10,
                                        LIMITED PARTNERSHIP

                                        By: NEA Partners 10, Limited
                                            Partnership, its General Partner

                                        By: /s/ Eugene A. Trainer, III
                                            ------------------------------------

                                        Name: Eugene A. Trainer, III
                                                        (print)
                                        Title: Administrative General Partner

                                        Address: 1119 St. Paul Street
                                                 Baltimore, MD 21202

                                        NEA VENTURES 2001, L.P.

                                        By:

                                        By: /s/ Pamela J. Clark
                                            ------------------------------------

                                        Name: Pamela J. Clark
                                                        (print)
                                        Title: General Partner

                                        Address: 1119 St. Paul Street
                                                 Baltimore, MD 21202

                                        PAMINA S.a.

                                        By: PAMINA S.a.

                                        By: /s/ Stephane Carnot
                                            ------------------------------------

                                        Name: Stephane Carnot
                                                        (print)
                                        Title:

                                        Address: 14 Willow Road
                                                 London
                                                 NW3 1TJ
                                                 United Kingdom

<PAGE>

                                        MONTAGU NEWHALL GLOBAL
                                        PARTNERS, L.P.

                                        By: Montagu Newhall General
                                            Partners, LP

                                        By: /s/ C. Ashton Newhall
                                            ------------------------------------

                                        Name: C. Ashton Newhall
                                                        (print)
                                        Title: General Partner

                                        Address: 4750 Owings Mills Blvd.
                                                 Owings Mills, MD 21117

                                        HFM CHARITABLE REMAINDER
                                        TRUST

                                        By:

                                        By: /s/ Roy M. Jones
                                            ------------------------------------

                                        Name: Roy M. Jones
                                                        (print)
                                        Title: Authorized Agent

                                        Address: 3060 Peachtree Road NW,
                                                 19th Floor Atlanta, GA
                                                 30305

                                        AEOW 2000 LP

                                        By:

                                        By: /s/ Bernard Osher
                                            ------------------------------------

                                        Name: Bernard Osher
                                                        (print)
                                        Title: Member Manager

                                        Address: 909 Montgomery Street,
                                                 Suite 600 San Francisco,
                                                 CA 94133

<PAGE>

                                        MERLIN BIOMED PRIVATE EQUITY FUND, L.P.

                                        By: /s/ Dominique Semon
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Dominique Semon
                                                        (print)
                                        Title: Fund Manager

                                        Address: 230 Park Avenue
                                                 Suite 928
                                                 New York, NY 10169

                                        INVEMED FUND, L.P.

                                        By: /s/ John Baran
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: John Baran
                                                        (print)
                                        Title: CFO

                                        Address: 375 Park Avenue
                                                 Suite 2205
                                                 New York, NY 10152

                                        HEALTHCAP 1999 KB

                                        By: Healthcap 1999 GP AB
                                            ------------------------------------

                                        By: /s/ Per Samuelson
                                            /s/ Staffan Lindstrand
                                            ------------------------------------

                                        Name: Per Samuelson Staffan Lindstrand
                                                        (print)
                                        Title:  Partner            Partner

                                        Address:

<PAGE>

                                        OFCO CLUB

                                        By: Odlander, Fredrikson & Co. AB

                                        By: /s/ Per Samuelson
                                            /s/ Staffan Lindstrand
                                            ------------------------------------

                                        Name: Per Samuelson Staffan Lindstrand
                                                        (print)
                                        Title:   Partner             Partner

                                        Address:

                                        HEALTHCAP 1999 GBR

                                        By: /s/ Jurgen Busch
                                            ------------------------------------

                                        By: ____________________________________

                                        Name: Jurgen Busch
                                                        (print)
                                        Title:  Managing Director of the General
                                        Partner Healthcap 1999 GBR

                                        Address: Kurfurstendamm 48-49
                                                 10707 Berlin, GERMANY

<PAGE>

                                        OTHER STOCKHOLDERS:

                                        KEVIN A. STANLEY

                                        ________________________________________

                                        Address: 4112 NE Pembroke Lane
                                                 Lee's Summit, MO 64064

                                        FMR CORPORATION

                                        By: ____________________________________

                                        By: ____________________________________

                                        Name:___________________________________
                                                        (print)
                                        Title:

                                        Address:

                                        ROBERT A. CONERLY

                                         /s/ Robert Conerly
                                        ----------------------------------------

                                        Address:

                                        BARRIE ALIOTH

                                         /s/ Barrie Lea Alioth
                                        ----------------------------------------

                                        Address: 926 Champion Circle
                                                 Longmont, Co 80803

                                        WILLIAM PONCY

                                         /s/ William Poncy
                                        ----------------------------------------

                                        Address: 1251 North Vire Drive
                                                 Erie, CO 80516

<PAGE>

                                        JEFFREY DAVIS

                                         /s/ Jeff Davis
                                        ----------------------------------------

                                        Address: 4939 Sundance Square
                                                 Boulder, CO 80301

                                        PAMELA HERRIOTT

                                         /s/ Pamela Herriott
                                        ----------------------------------------

                                        Address: 582 Brainard Circle
                                                 Lafayette, CO 80026

                                        DAVE KATTERHENRICH

                                         /s/ Dave Katterhenrich
                                        ----------------------------------------

                                        Address: 4984 Somerset Drive
                                                 Prairie Village, KS 66207

                                        TERRY SHELTON

                                         /s/ Terry Shelton
                                        ----------------------------------------

                                        Address: 3404 Thornbird Street
                                                 Blue Springs, MO 64015

                                        LINDA ZIMMERMAN

                                         /s/ Linda Zimmerman
                                        ----------------------------------------

                                        Address:

                                        KATHLEEN PIEKARSKI

                                        ________________________________________

                                        Address:

<PAGE>

                                        LINNEA TANNER

                                         /s/ Linnea Tanner
                                        ----------------------------------------

                                        Address:

                                        CATHY S. INOUYE

                                         /s/ Cathy S. Inouye
                                        ----------------------------------------

                                        Address: 2734 Meadow Mountain Trail
                                                 Lafayette, CO 80026

                                        ANDREE MICHELLE MERILEES

                                         /s/ Andree Michelle Merilees
                                        ----------------------------------------

                                        Address: 1895 Dover Street
                                                 Broomfield, CO 80020

                                        BOB REYNOLDS

                                        ________________________________________

                                        Address:

<PAGE>

                                   EXHIBIT C-1

                               OTHER STOCKHOLDERS

                                Domain Associates, L.L.C.

                                FMR Corporation

                                HealthCap 1999 GBR

                                Aberdare Ventures, L.P.

                                Kevin A. Stanley

                                Robert A. Conerly

                                Barrie Alioth

                                William Poncy

                                Jeffrey Davis

                                Pamela Herriott

                                Dave Katterhenrich

                                Terry Shelton

                                Linda Zimmerman

                                Kathleen Piekarski

                                Cathy Inouye

                                Linnea Tanner

                                Andree Michelle Merilees

                                Bob Reynolds<PAGE>

                                                                     EXHIBIT 4.4

                              PHARMION CORPORATION

                                    AMENDMENT

                  This Amendment (the "Amendment") is made and entered into as
of April 8, 2003 by and among Patrick Mahaffy and Judith Hemberger (the
"Founders"), Pharmion Corporation, a Delaware corporation (the "Company"),
Celgene Corporation, a Delaware corporation ("Celgene"), Penn Pharmaceuticals
Holdings Limited, a corporation organized under the laws of England and Wales
("Penn"), and the preferred stockholders of the Company listed on the signature
pages that follow this Amendment.

                                    RECITALS

                  WHEREAS, the Company, the Founders and the holders of the
Company's Series A Preferred Stock and Series B Preferred Stock entered into an
Amended and Restated Investors' Rights Agreement, dated as of November 30, 2001
(the "Agreement"), which provided such holders with certain registration rights;

                  WHEREAS, in connection with the issuance of a warrant to
Celgene to purchase shares of the Company's Series B Preferred Stock, the
Company and Celgene entered into a letter agreement, dated September 20, 2002,
pursuant to which Celgene became a party to the Agreement;

                  WHEREAS, in connection with the sale of the Company's Series C
Preferred Stock, the Agreement was further amended by the Series C Omnibus
Amendment Agreement, dated as of October 11, 2002, by and among the Company, the
Founders and the stockholders of the Company (the Agreement as so amended, the
"Investors' Rights Agreement");

                  WHEREAS, the Company wishes to sell to each of Celgene and
Penn a promissory note convertible into shares of the Company's common stock and
a warrant to purchase shares of the Company's common stock; and

                  WHEREAS, to induce Celgene and Penn to purchase such notes and
warrants, the Company, the Founders and the preferred stockholders of the
Company wish to provide Celgene and Penn with the registration rights under the
Investors' Rights Agreement with respect to the shares of the Company's common
stock issuable upon conversion or exercise of such notes and warrants;

                  NOW, THEREFORE, pursuant to the amendment and waiver
provisions of the Investors' Rights Agreement, the Company, the Founders,
Celgene, Penn and the holders of a majority of the Series A Registrable
Securities and 55% of the Senior Preferred Registrable Securities outstanding
(not including the Founders' Stock) (as such terms are defined in the Investors'
Rights Agreement) hereby agree to amend the Investors' Rights Agreement as
follows:

                                       1

<PAGE>

                                    AGREEMENT

                  1.       DEFINITIONS. Section 1.1 of the Investors' Rights
Agreement is hereby amended as follows:

                           (a)      By amending and restating clause (i) of
subsection (d) of such section in its entirety as follows:

                                    "(i) the shares of Common Stock issuable or
                                    issued upon (A) conversion of the Series A
                                    Preferred Stock and the Senior Preferred
                                    Stock, including any shares of Common Stock
                                    issuable or issued upon conversion of the
                                    Series B Preferred Stock issuable or issued
                                    to Celgene Corporation (together with its
                                    permitted successors and assigns, "Celgene")
                                    upon exercise of that certain Warrant to
                                    purchase shares of Series B Preferred Stock,
                                    or (B) conversion or exercise of the New
                                    Securities (as defined below),"

                           (b)      By amending and restating the definition of
"Senior Preferred Registrable Securities" in subsection (e) of such section in
its entirety as follows:

                                    "Senior Preferred Registrable Securities"
                                    means Registrable Securities consisting of
                                    Common Stock issuable or issued upon
                                    conversion or exercise of shares of Senior
                                    Preferred Stock or New Securities;

                           (c)      By adding a new subsection to the end of
such section, which will be and read as follows:

                                    "(k) The term "New Securities" means that
                                    certain (i) five year senior convertible
                                    promissory note issued to Celgene in the
                                    principal amount of $12,000,000, convertible
                                    into shares of Common Stock at an initial
                                    conversion price of $2.75 per share, (ii)
                                    five year warrant issued to Celgene to
                                    purchase 1,454,545 shares of Common Stock at
                                    an initial exercise price of $2.75 per
                                    share, (iii) five year convertible
                                    promissory note issued to Penn
                                    Pharmaceuticals Holdings Limited (together
                                    with its permitted successors and assigns,
                                    "Penn") in the principal amount of
                                    $2,000,000, convertible into shares of
                                    Common Stock at an initial conversion price
                                    of $2.75 per share, (iv) five year warrant
                                    issued to Penn to purchase 242,424 shares of
                                    Common Stock at an initial exercise price of
                                    $2.75 per share and (v) any and all
                                    continuations, extensions, modifications,
                                    refinancings, replacements and renewals
                                    thereof."

                  2.       ADDITION OF PENN AS A PARTY TO THE INVESTORS' RIGHTS
AGREEMENT. By its signature to this Amendment, Penn is hereby added as a party
to the Investors' Rights Agreement, effective as of the date hereof.

                                       2
<PAGE>

                  3.       AMENDMENT OF EXHIBIT B TO THE INVESTORS' RIGHTS
AGREEMENT. Pursuant to Section 3.4 of the Investors' Rights Agreement, Exhibit B
to the Investors' Rights Agreement is hereby amended, as set forth on the
Exhibit hereto, to reflect the addition of Celgene as a party to the Investors'
Rights Agreement as a Series B Investor, and that such amendment shall satisfy
the requirement of the last sentence of such Section 3.4.

                  4.       ACKNOWLEDGEMENT OF CELGENE AND PENN AS PARTIES TO THE
INVESTORS' RIGHTS AGREEMENT. By its signature to this Amendment, each preferred
stockholder agrees and acknowledges that each of Celgene and Penn is a party to
the Investors' Rights Agreement.

                  5.       GOVERNING LAW. This Amendment shall be governed,
construed and interpreted in accordance with the laws of the State of Delaware,
without giving effect to principles of conflicts of law.

                  6.       COUNTERPARTS. This Amendment may be executed in any
number of counterparts, each of which shall be deemed an original and all of
which together shall constitute one and the same instrument. The signature by a
stockholder of the Company executing this Amendment shall be deemed the
signature of such person in his, her or its capacity as the holder of all such
shares of capital stock of the Company held by such person on the date hereof.
This Amendment may be signed by facsimile sig natures.

                  7.       TITLES AND SUBTITLES. The titles and subtitles used
in this Amendment are used for convenience only and are not to be considered in
construing or interpreting this Amendment.

                            [Signature Pages Follow]

                                       3
<PAGE>

The parties have executed this Amendment as of the date first written above.

                                       PHARMION CORPORATION

                                       By:    /s/ Patrick J. Mahaffy
                                             -----------------------------------
                                              Patrick J. Mahaffy
                                              President and CEO

                                       CELGENE CORPORATION

                                       By:    /s/ Robert J. Hugin
                                             -----------------------------------
                                              Name: Robert J. Hugin
                                              Title: Senior Vice President & CFO

                                       PENN PHARMACEUTICALS HOLDINGS LIMITED

                                       By:    /s/ Craig R. Rennie
                                             -----------------------------------
                                              Name: Craig R. Rennie
                                              Title: Chief Executive

                                       By:    /s/ D. G. Henderson
                                             -----------------------------------
                                              Name: D. G. Henderson
                                              Title: Finance Director

                                        /s/ Patrick J. Mahaffy
                                       -----------------------------------------
                                       Patrick J. Mahaffy

                                       Address:     2525 28th Street
                                                    Boulder, CO 80301

                                        /s/ Judith A. Hemberger
                                       -----------------------------------------
                                       Judith A. Hemberger

                                       Address:     2525 28th Street
                                                    Boulder, CO 80301

                                       4
<PAGE>

                                       PREFERRED STOCKHOLDERS:

                                       VERSANT VENTURE CAPITAL I, L.P.

                                       By:  Versant Ventures I, LLC

                                       By:   /s/ Brian Atwood
                                            ------------------------------------

                                       Name:        Brian Atwood
                                       Title:       Managing Director

                                       Address:     3000 Sand Hill Road
                                                    BLDG. 1 - Suite 260
                                                    Menlo Park, CA 94025

                                       VERSANT SIDE FUND I, L.P.

                                       By:  Versant Ventures I, LLC

                                       By:   /s/ Brian Atwood
                                            ------------------------------------

                                       Name:        Brian Atwood
                                       Title:       Managing Director

                                       Address:     3000 Sand Hill Road
                                                    BLDG. 1 - Suite 260
                                                    Menlo Park, CA 94025

                                       VERSANT AFFILIATES FUND 1-A, L.P.

                                       By:  Versant Ventures I, LLC

                                       By:   /s/ Brian Atwood
                                            ------------------------------------

                                       Name:        Brian Atwood
                                       Title:       Managing Director

                                       Address:     3000 Sand Hill Road
                                                    BLDG. 1 - Suite 260
                                                    Menlo Park, CA 94025

                                       5
<PAGE>

                                       VERSANT AFFILIATES FUND 1-B, L.P.

                                       By:  Versant Ventures I, LLC

                                       By:   /s/ Brian Atwood
                                            ------------------------------------

                                       Name:        Brian Atwood
                                       Title:       Managing Director

                                       Address:     3000 Sand Hill Road
                                                    BLDG. 1 - Suite 260
                                                    Menlo Park, CA 94025

                                       ABERDARE VENTURES, L.P.

                                       By:  Aberdare GP, L.L.C., its
                                            General Partner

                                       By:   /s/ Paul H. Klingenstein
                                            ------------------------------------

                                       Name:       Paul H. Klingenstein
                                       Title:      Managing Partner

                                       Address:    One Embarcadero Center, #4000
                                                   San Francisco, CA 94111

                                       ABINGWORTH BIOVENTURES II
                                       SICAV

                                       By:  /s/ Genevieve Blauen Gerard Muller
                                            ------------------------------------

                                       Name:    Genevieve Blauen   Gerard Muller
                                       Title:   Company Secretary  Mandatory

                                       Address:    231, Val des Bons-Malades
                                                   L-2121 Luxembourg

                                       TECHNOGEN ENTERPRISES LLC

                                       By:   /s/ Isaac Stein
                                            ------------------------------------

                                       Name:        Isaac Stein
                                       Title:       Member

                                       Address:     P.O. Box 2088
                                                    Menlo Park, CA 94026

                                       6
<PAGE>

                                       DOMAIN PARTNERS IV, L.P.

                                       By:  One Palmer Square Associates IV,
                                            L.L.C., its General Partner

                                       By:   /s/ Kathleen Schoemaker
                                            ------------------------------------

                                       Name:     Kathleen Schoemaker
                                       Title:    Managing Member

                                       Address:     One Palmer Square
                                                    Princeton, NJ 08542

                                       DP IV ASSOCIATES, L.P.

                                       By:  One Palmer Square Associates IV,
                                            L.L.C., its General Partner

                                       By:   /s/ Kathleen Schoemaker
                                            ------------------------------------

                                       Name:     Kathleen Schoemaker
                                       Title:    Managing Member

                                       Address:     One Palmer Square
                                                    Princeton, NJ 08542

                                       DOMAIN ASSOCIATES, L.L.C.

                                       By:   /s/ Kathleen Schoemaker
                                            ------------------------------------

                                       Name:     Kathleen Schoemaker
                                       Title:    Managing Member

                                       Address:     One Palmer Square
                                                    Princeton, NJ 08542

                                       7
<PAGE>

                                       ROGER G. KENNEDY

                                       _________________________________________

                                       Address:     855 El Caminito
                                                    Santa Fe, New Mexico 87501

                                       JAMES C. YOUNG

                                       _________________________________________

                                       Address:     118 East Platte Avenue
                                                    Colorado Springs, CO 80903

                                       ANN YOUNG

                                       _________________________________________

                                       Address:     118 East Platte Avenue
                                                    Colorado Springs, CO 80903

                                       CAM GARNER

                                       /s/ Cam Garner
                                       -----------------------------------------

                                       Address:     6363 Greenwich Dr.
                                                    San Diego, CA 92122

                                       PETER H. JAKES AND KAREN S. JAKES

                                       /s/ Peter H. Jakes /s/ Karen S. Jakes
                                       -----------------------------------------

                                       Address:  520 East 86th Street, Apt. 13-C
                                                 New York, NY 10028

                                       NOMURA INTERNATIONAL PLC

                                       By:   /s/ Denise Pollard-Knight
                                            ------------------------------------

                                       Name:        Denise Pollard-Knight
                                       Title:       Head of Healthcare Private
                                                    Equity

                                       Address:     1 St. Martin's-le-Grand
                                                    London EC1A 4NP

                                       8
<PAGE>

                                       ORRICK, HERRINGTON & SUTCLIFFE, LLP

                                       By:  ____________________________________

                                       Name:        Peter Cohn
                                       Title:       Member

                                       Address:     1020 Marsh Road
                                                    Menlo Park, CA 94025

                                       ORRICK INVESTMENTS 2002 LLC

                                       By: _____________________________________

                                       Name:        Peter Cohn
                                       Title:       Member

                                       Address:     1020 Marsh Road
                                                    Menlo Park, CA 94025

                                       PETER COHN, AS TRUSTEE, OR THE
                                       SUCCESSOR TRUSTEE OR TRUSTEES,
                                       U/A/D, DATED AUGUST 29, 1995,
                                       AS AMENDED, CREATING THE PETER
                                       COHN REVOCABLE TRUST.

                                       By: _____________________________________

                                       Name:        Peter Cohn
                                       Title:       Trustee

                                       Address:     1020 Marsh Road
                                                    Menlo Park, CA 94025

                                       9
<PAGE>

                                      PROQUEST INVESTMENTS II, L.P.

                                      By: /s/ Pasquale DeAngelis
                                          --------------------------------------

                                      Name:      Pasquale DeAngelis
                                      Title:     Chief Financial Officer

                                      Address:   600 Alexander Park, Suite 204
                                                 Princeton, NJ 08540

                                      PROQUEST INVESTMENTS II ADVISORS FUND,
                                      L.P.

                                      By: /s/ Pasquale DeAngelis
                                          --------------------------------------

                                      Name:      Pasquale DeAngelis
                                      Title:     Chief Financial Officer

                                      Address:   600 Alexander Park, Suite 204
                                                 Princeton, NJ 08540

                                      NEOMED INNOVATION III, L.P.

                                      By:  Neomed Innovation III Limited, its
                                           General Partner

                                      By: /s/ Simon Young
                                          --------------------------------------

                                      Name:    Simon Young
                                      Title:   Director

                                      Address: P.O. Box 539, No. 1 Wesley Street
                                               St. Helier, Jersey L.I. JE4 SUT

                                      MERLIN BIOMED PRIVATE EQUITY FUND, L.P.

                                      By:  _____________________________________

                                      Name       Dominique Semon
                                      Title:     Fund Manager

                                      Address:   230 Park Avenue, Suite 928
                                                 New York, NY 10169

                                       10

<PAGE>

                                       THE BAY CITY CAPITAL FUND III, L.P.

                                       By: Bay City Capital Management III, LLC

                                       By: /s/ Carl Goldfischer
                                           -------------------------------------

                                       Name:      Carl Goldfischer
                                       Title:     Manager and Managing Director
                                       General Partner of: The Bay City Capital
                                       Fund III, L.P.

                                       Address:   750 Battery St., Suite 600
                                                  San Francisco, CA 94111

                                       THE BAY CITY CAPITAL FUND III
                                       CO-INVESTMENT FUND, L.P.

                                       By:  Bay City Capital Management III, LLC

                                       By: /s/ Carl Goldfischer
                                           -------------------------------------

                                       Name:      Carl Goldfischer
                                       Title:     Manager and Managing Director
                                       General Partner of: The Bay City Capital
                                       Fund III Co-Investment, L.P.

                                       Address:   750 Battery St., Suite 600
                                                  San Francisco, CA 94111

                                       PAMINA S.A.

                                       By: _____________________________________

                                       Name:      Stephane Carnot
                                       Title:     Chairman

                                       Address:   14 Willow Road
                                                  London
                                                  NW3 1TJ
                                                  United Kingdom

                                       11

<PAGE>

                                       NEW ENTERPRISE ASSOCIATES 10, LIMITED
                                       PARTNERSHIP

                                       By: NEA Partners 10, Limited Partnership,
                                           its General Partner

                                       By: /s/ Eugene Trainor, III
                                           -------------------------------------

                                       Name:    Eugene Trainor, III
                                       Title:   Administrative General Partner &
                                                Chief Operating Officer

                                       Address:     1119 St. Paul Street
                                                    Baltimore, MD 21202

                                       NEA VENTURES 2001, L.P.

                                       By: /s/ Pamela J. Clark
                                           -------------------------------------

                                       Name:    Pamela J. Clark
                                       Title:   General Partner

                                       Address:     1119 St. Paul Street
                                                    Baltimore, MD 21202

                                       MONTAGU NEWHALL GLOBAL PARTNERS, L.P.

                                       By:  Montagu Newhall General Partner, LP

                                       By: /s/ C. Ashton Newhall
                                           -------------------------------------

                                       Name:        C. Ashton Newhall
                                       Title:       General Partner

                                       Address:     4750 Owings Mills Blvd.
                                                    Owings Mills, MD 21117

                                       12

<PAGE>

                                       HFM CHARITABLE REMAINDER TRUST

                                       By: /s/ Roy Jones
                                           -------------------------------------

                                       Name:      Roy M. Jones
                                       Title:     Authorized Agent

                                       Address:   3060 Peachtree Road NW, 19th
                                                  Floor Atlanta, GA 30305

                                       AEOW 2000 LP

                                       By: _____________________________________

                                       Name:      Bernard M. Osher
                                       Title:

                                       Address:   909 Montgomery Street, Suite
                                                  600 San Francisco, CA 94133

                                       INVEMED FUND, L.P.

                                       By: /s/ John Baran
                                           -------------------------------------

                                       Name:      John Baran
                                       Title:     Chief Financial Officer

                                       Address:   375 Park Avenue, Suite 2205
                                                  New York, NY 10152

                                       13

<PAGE>

                                       HEALTHCAP 1999 KB

                                       By: HealthCap 1999 GP AB

                                       By: /s/ Per Samuelson
                                           /s/ A. Hulton Forsberg
                                           -------------------------------------

                                       Name: Per Samuelson A. Hulton Forsberg
                                                         (print)
                                       Title: Partner            Partner
                                       Address:

                                       OFCO CLUB

                                       By: Odlander, Fredrikson & Co. AB

                                       By: /s/ Per Samuelson
                                           -------------------------------------

                                       Name:  Per Samuelton
                                       Title: Partner

                                       Address:

                                       HEALTHCAP 1999 GBR

                                       By: /s/ Jurgen Busch
                                           -------------------------------------

                                       Name:      Jurgen Busch
                                       Title:     Managing Director

                                       Address:   Kurfurstendamm 48-49
                                                  10707 Berlin, Germany

                                       14

<PAGE>

                                       SCHWEIZERHALL INVESTMENT LIMITED

                                       By: /s/ P.A. Bolton
                                           -------------------------------------

                                       Name:  P.A. Bolton
                                       Title: Alternate Director to PGF Newbald

                                       Address: N(degree)1 Seaton Place
                                                PO Box 641
                                                St. Helier
                                                Jersey JE4 8YJ
                                                Channel Islands

                                       GENERAL ELECTRIC PENSION TRUST
                                       By: GE Asset Management Incorporated,
                                           Its Investment Manager

                                       By: /s/ Patrick J. McNeel
                                           -------------------------------------

                                       Name:  Patrick J. McNeel
                                       Title: VP - Private Equity

                                       Address:  3003 Summer Street
                                                 Stamford, CT 06905

                                       MICHAEL AND DEANNE BORER
                                       FAMILY TRUST DATED
                                       DECEMBER 7, 2001

                                       By: _____________________________________

                                       Name:     Michael Borer
                                       Title:    Trustee

                                       Address:  806 North Rios Avenue
                                                 Solana Beach, CA 92075

                                       15

<PAGE>

                                       ERLE MAST

                                       /s/ Erle Mast
                                       -----------------------------------------

                                       Address:   8417 Strawberry Lane
                                                  Niwot, CO 80503

                                       WEBB BURNS

                                       _________________________________________

                                       Address:

                                       16

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