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Exhibit 10.2    
    

GENOPTIX, INC.

2001 EQUITY INCENTIVE PLAN

Adopted May 16, 2001

Approved By Stockholders July 31, 2001

Termination Date: May 15, 2011  

        1.    PURPOSES.    

         (a)    Amendment and Restatement.    The Plan amends and restates the Genoptix, Inc. 1999 Stock Incentive Plan
adopted March 21,
1999 (the "Prior Plan"). A Participant's outstanding options granted under the Prior Plan shall be governed by such Prior Plan, unless otherwise agreed to in writing by such Participant (in which
case, such options will be governed by the terms of this Plan). 

         (b)    Available Stock Awards.    The purpose of the Plan is to provide a means by which eligible recipients of Stock
Awards may be given an
opportunity to benefit from increases in value of the Common Stock through the granting of the following Stock Awards: (i) Incentive Stock Options, (ii) Nonstatutory Stock Options,
(iii) stock bonuses and (iv) rights to acquire restricted stock. 

        (c)    General Purpose.    The Company, by means of the Plan, seeks to retain the services of the group of persons
eligible to receive Stock
Awards, to secure and retain the services of new members of this
group and to provide incentives for such persons to exert maximum efforts for the success of the Company and its Affiliates. 

        2.    DEFINITIONS.    

        (a)   "Affiliate" means any parent corporation or subsidiary corporation of the Company, whether now or
hereafter existing, as those terms are defined in Sections 424(e) and (f), respectively, of the Code. 

        (b)   "Board" means the Board of Directors of the Company. 

        (c)   "Cause" means, with respect to a particular Participant, the occurrence of any of the following:
(i) such Participant's conviction of any felony or any crime involving fraud or dishonesty; (ii) such Participant's participation (whether by affirmative act or omission) in a fraud, act
of dishonesty or other act of misconduct against the Company and/or its Affiliates and which has a material adverse effect on the Company and/or its Affiliates; (iii) conduct by such
Participant which, based upon a good faith and reasonable factual investigation by the Company (or, if such Participant is an Officer, by the Board), demonstrates such Participant's unfitness to
serve; (iv) such Participant's material violation of any fiduciary duty, or duty of loyalty owed to the Company and/or its Affiliates; (v) such Participant's violation of state or
federal law in connection with such Participant's performance of his/her job which has a material adverse effect on the Company and/or its Affiliates; (vi) such Participant's breach of any
material term of any contract between such Participant and the Company and/or its Affiliates; and (vii) such Participant's violation of Company policy which has a material adverse effect on the
Company and/or its Affiliates. Notwithstanding the foregoing, such Participant's Disability shall not constitute Cause as set forth herein. The determination that a termination is for Cause shall be
made by the Board or the Committee in its sole and exclusive judgment and discretion. 

        (d)   "Change in Control" means: (i) a sale of all or substantially all of the assets of the
Company; (ii) a merger or consolidation in which the Company is not the surviving entity and in 

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which
the holders of the Company's outstanding voting stock immediately prior to such transaction own, immediately after such transaction, securities representing less than fifty percent (50%) of the
voting power of the entity surviving such transaction or, where the surviving entity is a wholly-owned subsidiary of another entity, the surviving entity's parent; (iii) a reverse merger in
which the Company is the surviving entity but the shares of Common Stock outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of
securities of the surviving entity's parent, cash or otherwise, and in which the holders of the Company's outstanding voting stock immediately prior to such transaction own, immediately after such
transaction, securities representing less than fifty percent (50%) of the voting power of the Company or, where the Company is a wholly-owned subsidiary of another entity, the Company's parent; or
(iv) after the Listing Date, an acquisition by any person, entity or group within the meaning of Section 13(d) or 14(d) of the Exchange Act, or any comparable successor provisions
(excluding any employee benefit plan, or related trust, sponsored or maintained by the Company or subsidiary of the Company or other entity controlled by the Company) of the beneficial ownership
(within the meaning of Rule 13d-3 promulgated under the Exchange Act, or comparable successor rule) of securities of the Company representing at least fifty percent (50%) of the
combined voting power entitled to vote in the election of Directors; provided, however, that nothing in this subsection 2(d) shall apply to a sale of assets, merger or other transaction effected
exclusively for the purpose of changing the domicile of the Company. 

        (e)   "Code" means the Internal Revenue Code of 1986, as amended. 

        (f)    "Committee" means a committee of one or more members of the Board appointed by the Board in
accordance with subsection 3(c). 

        (g)   "Common Stock" means the common stock of the Company. 

        (h)   "Company" means Genoptix, Inc., a Delaware corporation. 

        (i)    "Consultant" means any person, including an advisor, (i) engaged by the Company or an
Affiliate to render consulting or advisory services and who is compensated for such services or (ii) who is a member of the Board of Directors of an Affiliate. However, the term "Consultant"
shall not include either Directors who are not compensated by the Company for their services as Directors or Directors who are merely paid a director's fee by the Company for their services as
Directors. 

        (j)    "Continuous Service" means that the Participant's service with the Company or an Affiliate,
whether as an Employee, Director or Consultant, is not interrupted or terminated. The Participant's Continuous Service shall not be deemed to have terminated merely because of a change in the capacity
in which the Participant renders service to the Company or an Affiliate as an Employee, Consultant or Director or a change in the entity for which the Participant renders such service, provided that
there is no interruption or termination of the Participant's Continuous Service. For example, a change in status from an Employee of the Company to a Consultant of an Affiliate or a Director will not
constitute an interruption of Continuous Service. The Board or the chief executive officer of the Company, in that party's sole discretion, may determine whether Continuous Service shall be considered
interrupted in the case of any leave of absence approved by that party, including sick leave, military leave or any other personal leave. 

        (k)   "Covered Employee" means the chief executive officer and the four (4) other highest
compensated officers of the Company for whom total compensation is required to be reported to stockholders under the Exchange Act, as determined for purposes of Section 162(m) of the Code. 

        (l)    "Director" means a member of the Board of Directors of the Company. 

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        (m)  "Disability" means (i) before the Listing Date, the inability of a person, in the opinion
of a qualified physician acceptable to the Company, to perform the major duties of that person's position with the Company or an Affiliate of the Company because of the sickness or injury of the
person and (ii) after the Listing Date, the permanent and total disability of a person within the meaning of Section 22(e)(3) of the Code. 

        (n)   "Employee" means any person employed by the Company or an Affiliate. Mere service as a Director
or payment of a director's fee by the Company or an Affiliate shall not be sufficient to constitute "employment" by the Company or an Affiliate. 

        (o)   "Exchange Act" means the Securities Exchange Act of 1934, as amended. 

        (p)   "Fair Market Value" means, as of any date, the value of the Common Stock determined as follows: 

          (i)  If the Common Stock is listed on any established stock exchange or traded on the Nasdaq National Market or the Nasdaq
SmallCap Market, the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such
exchange or market (or the exchange or market with the greatest volume of trading in the Common Stock) on the last market trading day prior to the day of determination, as reported in  The Wall Street Journal or such other source as the Board deems reliable. 

         (ii)  In the absence of such markets for the Common Stock, the Fair Market Value shall be determined in good faith by the
Board. 

       (iii)  Prior to the Listing Date, the value of the Common Stock shall be determined in a manner consistent with
Section 260.140.50 of Title 10 of the California Code of Regulations. 

        (q)   "Good Reason" means, with respect to a particular Participant, the occurrence of any of the
following events, conditions or actions taken by the Company without Cause and without such Participant's consent: (i) if such Participant is an Officer, a reduction in such Participant's
title, (ii) a change in such Participant's employment responsibilities with the Company which represents a material reduction in such Participant's level of responsibility, (iii) a
reduction in such Participant's level of base salary, or (iv) a relocation of such Participant's place of employment by more than fifty (50) miles. 

        (r)   "Incentive Stock Option" means an Option intended to qualify as an incentive stock option within
the meaning of Section 422 of the Code and the regulations promulgated thereunder. 

        (s)   "Listing Date" means the first date upon which any security of the Company is listed (or approved
for listing) upon notice of issuance on any securities exchange or designated (or approved for designation) upon notice of issuance as a national market security on an interdealer quotation system if
such securities exchange or interdealer quotation system has been certified in accordance with the provisions of Section 25100(o) of the California Corporate Securities Law of 1968. 

        (t)    "Non-Employee Director" means a Director who either (i) is not a current
Employee or Officer of the Company or its parent or a subsidiary, does not receive compensation (directly or indirectly) from the Company or its parent or a subsidiary for services rendered as a
consultant or in any capacity other than as a Director (except for an amount as to which disclosure would not be required under Item 404(a) of Regulation S-K promulgated pursuant to
the Securities Act ("Regulation S-K")), does not possess an interest in any other transaction as to which disclosure would be required under Item 404(a) of
Regulation S-K and is not engaged in a business relationship as to which disclosure would be required under Item 404(b) of Regulation S-K; or (ii) is
otherwise considered a "non-employee director" for purposes of Rule 16b-3. 

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        (u)   "Nonstatutory Stock Option" means an Option not intended to qualify as an Incentive Stock Option. 

        (v)   "Officer" means (i) before the Listing Date, any person designated by the Board as an
executive officer and (ii) on and after the Listing Date, a person who is an officer of the Company within the meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder. 

        (w)  "Option" means an Incentive Stock Option or a Nonstatutory Stock Option granted pursuant to the
Plan. 

        (x)   "Option Agreement" means a written agreement between the Company and an Optionholder evidencing
the terms and conditions of an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of the Plan. 

        (y)   "Optionholder" means a person to whom an Option is granted pursuant to the Plan or, if
applicable, such other person who holds an outstanding Option. 

        (z)   "Outside Director" means a Director who either (i) is not a current employee of the
Company or an "affiliated corporation" (within the meaning of Treasury Regulations promulgated under Section 162(m) of the Code), is not a former employee of the Company or an "affiliated
corporation" receiving compensation for prior services (other than benefits under a tax-qualified pension plan), was not an officer of the Company or an "affiliated corporation" at any
time and is not currently receiving direct or indirect remuneration from the Company or an "affiliated corporation" for services in any capacity other than as a Director or (ii) is otherwise
considered an "outside director" for purposes of Section 162(m) of the Code. 

        (aa) "Participant" means a person to whom a Stock Award is granted pursuant to the Plan or, if
applicable, such other person who holds an outstanding Stock Award. 

        (bb) "Plan" means this Genoptix, Inc. 2001 Equity Incentive Plan. 

        (cc) "Rule 16b-3" means Rule 16b-3 promulgated under the
Exchange Act or any successor to Rule 16b-3, as in effect from time to time. 

        (dd) "Securities Act" means the Securities Act of 1933, as amended. 

        (ee) "Stock Award" means any right granted under the Plan, including an Option, a stock bonus and a
right to acquire restricted stock. 

        (ff)  "Stock Award Agreement" means a written agreement between the Company and a holder of a Stock
Award evidencing the terms and conditions of an individual Stock Award grant. Each Stock Award Agreement shall be subject to the terms and conditions of the Plan. 

        (gg) "Ten Percent Stockholder" means a person who owns (or is deemed to own pursuant to
Section 424(d) of the Code) stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or of any of its Affiliates. 

        3.    ADMINISTRATION.    

         (a)    Administration by Board.    The Board shall administer the Plan unless and until the Board delegates
administration to a Committee, as
provided in subsection 3(c). 

         (b)    Powers of Board.    The Board shall have the power, subject to, and within the limitations of, the express
provisions of the Plan: 

          (i)  To determine from time to time which of the persons eligible under the Plan shall be granted Stock Awards; when and how
each Stock Award shall be granted; what type or combination of types of Stock Award shall be granted; the provisions of each Stock Award 

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granted
(which need not be identical), including the time or times when a person shall be permitted to receive Common Stock pursuant to a Stock Award; and the number of shares of Common Stock with
respect to which a Stock Award shall be granted to each such person. 

         (ii)  To construe and interpret the Plan and Stock Awards granted under it, and to establish, amend and revoke rules and
regulations for its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Stock Award Agreement, in a manner and to the
extent it shall deem necessary or expedient to make the Plan fully effective. 

       (iii)  To amend the Plan or a Stock Award as provided in Section 12. 

        (iv)  Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the
best interests of the Company which are not in conflict with the provisions of the Plan. 

         (c)    Delegation to Committee.    

          (i)  General. The Board may delegate administration of the Plan to a Committee or Committees of one (1) or more
members of the Board, and the term "Committee" shall apply to any person or persons to whom such authority has been delegated. If administration is delegated to a Committee, the Committee shall have,
in connection with the administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is
authorized to exercise (and references in this Plan to the Board shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of
the Plan, as may be adopted from time to time by the Board. The Board may abolish the Committee at any time and revest in the Board the administration of the Plan. 

         (ii)  Committee Composition when Common Stock is Publicly Traded. At such time as the Common Stock is publicly traded, in the
discretion of the Board, a Committee may consist solely of two or more Outside Directors, in accordance with Section 162(m) of the Code, and/or solely of two or more Non-Employee
Directors, in accordance with Rule 16b-3. Within the scope of such authority, the Board or the Committee may (1) delegate to a committee of one or more members of the Board
who are not Outside Directors the authority to grant Stock Awards to eligible persons who are either (a) not then Covered Employees and are not expected to be Covered Employees at the time of
recognition of income resulting from such Stock Award or (b) not persons with respect to whom the Company wishes to comply with Section 162(m) of the Code and/or (2) delegate to a
committee of one or more members of the Board who are not Non-Employee Directors the authority to grant Stock Awards to eligible persons who are not then subject to Section 16 of
the Exchange Act. 

         (d)    Effect of Board's Decision.    All determinations, interpretations and constructions made by the Board in good
faith shall not be
subject to review by any person and shall be final, binding and conclusive on all persons. 

        4.    SHARES SUBJECT TO THE PLAN.    

        (a)    Share Reserve.    Subject to the provisions of Section 11 relating to adjustments upon changes in Common
Stock, the Common Stock
that may be issued pursuant to Stock Awards shall not exceed in the aggregate nine million three hundred sixty-three thousand six hundred sixty-seven (9,363,667) shares of Common Stock. 

         (b)    Reversion of Shares to the Share Reserve.    If any Stock Award shall for any reason expire or otherwise
terminate, in whole or in
part, without having been exercised in full, the shares 

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of
Common Stock not acquired under such Stock Award shall revert to and again become available for issuance under the Plan. 

         (c)    Source of Shares.    The shares of Common Stock subject to the Plan may be unissued shares or reacquired shares,
 bought on the market
or otherwise. 

        (d)    Share Reserve Limitation.    Prior to the Listing Date and to the extent then required by
Section 260.140.45 of Title 10 of the
California Code of Regulations, the total number of shares of Common Stock issuable upon exercise of all outstanding Options and the total number of shares of Common Stock provided for under any stock
bonus or similar plan of the Company shall not exceed the applicable percentage as calculated in accordance with the conditions and exclusions of Section 260.140.45 of Title 10 of the
California Code of Regulations, based on the shares of Common Stock of the Company that are outstanding at the time the calculation is made.(1) 

	(1)
	Section 260.140.45
generally provides that the total number of shares issuable upon exercise of all outstanding options (exclusive of certain rights) and the total number of
shares called for under any stock bonus or similar plan shall not exceed a number of shares which is equal to 30% of the then outstanding shares of the issuer (convertible preferred or convertible
senior common shares counted on an as if converted basis), exclusive of shares subject to promotional waivers under Section 260.141, unless a percentage higher than 30% is approved by at least
two-thirds of the outstanding shares entitled to vote. 

        5.    ELIGIBILITY.    

         (a)    Eligibility for Specific Stock Awards.    Incentive Stock Options may be granted only to Employees. Stock
Awards other than Incentive
Stock Options may be granted to Employees, Directors and Consultants. 

         (b)    Ten Percent Stockholders.    

          (i)  A Ten Percent Stockholder shall not be granted an Incentive Stock Option unless the exercise price of such Option is at
least one hundred ten percent (110%) of the Fair Market Value of the Common Stock at the date of grant and the Option is not exercisable after the expiration of five (5) years from the date of
grant. 

         (ii)  Prior to the Listing Date, a Ten Percent Stockholder shall not be granted a Nonstatutory Stock Option unless the
exercise price of such Option is at least (i) one hundred ten percent (110%) of the Fair Market Value of the Common Stock at the date of grant or (ii) such lower percentage of the Fair
Market Value of the Common Stock at the date of grant as is permitted by Section 260.140.41 of Title 10 of the California Code of Regulations at the time of the grant of the Option. 

       (iii)  Prior to the Listing Date, a Ten Percent Stockholder shall not be granted a restricted stock award unless the purchase
price of the restricted stock is at least (i) one hundred percent (100%) of the Fair Market Value of the Common Stock at the date of grant or (ii) such lower percentage of the Fair
Market Value of the Common Stock at the date of grant as is permitted by Section 260.140.42 of Title 10 of the California Code of Regulations at the time of the grant of the restricted stock
award. 

        (c)    Section 162(m) Limitation.    Subject to the provisions of Section 11 relating to adjustments upon
changes in the shares
of Common Stock, no Employee shall be eligible to be granted Options covering more than two million (2,000,000) shares of Common Stock during any calendar year. This subsection 5(c) shall not apply
prior to the Listing Date and, following the Listing Date, this subsection 5(c) shall not apply until (i) the earliest of: (1) the first material modification of the Plan (including any
increase in the number of shares of Common Stock reserved for issuance under the Plan in accordance with Section 4); (2) the issuance of all of the 

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shares
of Common Stock reserved for issuance under the Plan; (3) the expiration of the Plan; or (4) the first meeting of stockholders at which Directors are to be elected that occurs
after the close of the third calendar year following the calendar year in which occurred the first registration of an equity security under Section 12 of the Exchange Act; or (ii) such
other date required by Section 162(m) of the Code and the rules and regulations promulgated thereunder. 

         (d)    Consultants.    

          (i)  Prior to the Listing Date, a Consultant shall not be eligible for the grant of a Stock Award if, at the time of grant,
either the offer or the sale of the Company's securities to such Consultant is not exempt under Rule 701 of the Securities Act ("Rule 701") because of the nature of the services that the
Consultant is providing to the Company, or because the Consultant is not a natural person, or as otherwise provided by Rule 701, unless the Company determines that such grant need not comply
with the requirements of Rule 701 and will satisfy another exemption under the Securities Act as well as comply with the securities laws of all other relevant jurisdictions. 

         (ii)  From and after the Listing Date, a Consultant shall not be eligible for the grant of a Stock Award if, at the time of
grant, a Form S-8 Registration Statement under the Securities Act ("Form S-8") is not available to register either the offer or the sale of the Company's
securities to such Consultant because of the nature of the services that the Consultant is providing to the Company, or because the Consultant is not a natural person, or as otherwise provided by the
rules governing the use of Form S-8, unless the Company determines both (i) that such grant (A) shall be registered in another manner under the Securities Act
(e.g., on a Form S-3 Registration Statement) or (B) does not require registration under the Securities Act in order to comply
with the requirements of the Securities Act, if applicable, and (ii) that such grant complies with the securities laws of all other relevant jurisdictions. 

       (iii)  Rule 701 and Form S-8 generally are available to consultants and advisors only if
(i) they are natural persons; (ii) they provide bona fide services to the issuer, its parents, its majority-owned subsidiaries or majority-owned subsidiaries of the issuer's parent; and
(iii) the services are not in connection with the offer or sale of securities in a capital-raising transaction, and do not directly or indirectly promote or maintain a market for the issuer's
securities. 

        6.    OPTION PROVISIONS.    

        Each
Option shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. All Options shall be separately designated Incentive Stock Options or
Nonstatutory Stock Options at the time of grant, and, if certificates are issued, a separate certificate or certificates will be issued for shares of Common Stock purchased on exercise of each type of
Option. The provisions of separate Options need not be identical, but each Option shall include (through incorporation of provisions hereof by reference in the Option or otherwise) the substance of
each of the following provisions: 

        (a)    Term.    Subject to the provisions of subsection 5(b) regarding Ten Percent Stockholders, no Option granted
prior to the Listing Date
shall be exercisable after the expiration of ten (10) years from the date it was granted, and no Incentive Stock Option granted on or after the Listing Date shall be exercisable after the
expiration of ten (10) years from the date it was granted. 

         (b)    Exercise Price of an Incentive Stock Option.    Subject to the provisions of subsection 5(b) regarding Ten
Percent Stockholders, the
exercise price of each Incentive Stock Option shall be not less than one hundred percent (100%) of the Fair Market Value of the Common Stock subject to the Option on the date the Option is granted.
Notwithstanding the foregoing, an Incentive 

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Stock
Option may be granted with an exercise price lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a
manner satisfying the provisions of Section 424(a) of the Code. 

        (c)    Exercise Price of a Nonstatutory Stock Option.    Subject to the provisions of subsection 5(b) regarding Ten
Percent Stockholders, the
exercise price of each Nonstatutory Stock Option granted prior to the Listing Date shall be not less than eighty-five percent (85%) of the Fair Market Value of the Common Stock subject to
the Option on the date the Option is granted. The exercise price of each Nonstatutory Stock Option granted on or after the Listing Date shall be not less than eighty-five percent (85%) of
the Fair Market Value of the Common Stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, a Nonstatutory Stock Option may be granted with an exercise price
lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a manner satisfying the provisions of
Section 424(a) of the Code. 

         (d)    Consideration.    The purchase price of Common Stock acquired pursuant to an Option shall be paid, to the
extent permitted by
applicable statutes and regulations, either (i) in cash at the time the Option is exercised or (ii) at the discretion of the Board at the time of the grant of the Option (or subsequently
in the case of a Nonstatutory Stock Option) (1) by delivery to the Company of other Common Stock, (2) according to a deferred payment or other similar arrangement with the Optionholder
or (3) in any other form of legal consideration that may be acceptable to the Board. Unless otherwise specifically provided in the Option, the purchase price of Common Stock acquired pursuant
to an Option that is paid by delivery to the Company of other Common Stock acquired, directly or indirectly from the Company, shall be paid only by shares of the Common Stock of the Company that have
been held for more than six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting purposes). At any time that the Company is
incorporated in Delaware, payment of the Common Stock's "par value," as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 

        In
the case of any deferred payment arrangement, interest shall be compounded at least annually and shall be charged at the market rate of interest necessary to avoid a charge to
earnings for financial accounting purposes. 

         (e)    Transferability of an Incentive Stock Option.    An Incentive Stock Option shall not be transferable except by
will or by the laws of
descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing, the Optionholder may, by delivering written notice to
the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 

         (f)    Transferability of a Nonstatutory Stock Option.    A Nonstatutory Stock Option granted prior to the Listing
Date shall not be
transferable except by will or by the laws of descent and distribution and, to the extent provided in the Option Agreement, to such further extent as permitted by Section 260.140.41(d) of Title
10 of the California Code of Regulations at the time of the grant of the Option, and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. A Nonstatutory Stock Option
granted on or after the Listing Date shall be transferable to the extent provided in the Option Agreement. If the Nonstatutory Stock Option does not provide for transferability, then the Nonstatutory
Stock Option shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder.
Notwithstanding the foregoing, the Optionholder may, by delivering written notice to the Company, in a form satisfactory to the 

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Company,
designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 

        (g)    Vesting Generally.    The total number of shares of Common Stock subject to an Option may, but need not, vest
and therefore become
exercisable in periodic installments that may, but need not, be equal. The Option may be subject to such other terms and conditions on the time or times when it may be exercised (which may be based on
performance or other criteria) as the Board may deem appropriate. The vesting provisions of individual Options may vary. The provisions of this subsection 6(g) are subject to any Option provisions
governing the minimum number of shares of Common Stock as to which an Option may be exercised. 

        (h)    Minimum Vesting Prior to the Listing Date.    Notwithstanding the foregoing subsection 6(g), to the extent that
the following
restrictions on vesting are required by Section 260.140.41(f) of Title 10 of the California Code of Regulations at the time of the grant of the Option, then: 

          (i)  Options granted prior to the Listing Date to an Employee who is not an Officer, Director or Consultant shall provide for
vesting of the total number of shares of Common Stock at a rate of at least twenty percent (20%) per year over five (5) years from the date the Option was granted, subject to reasonable
conditions such as continued employment; and 

         (ii)  Options granted prior to the Listing Date to Officers, Directors or Consultants may provide for vesting at any time or
during any period established by the Company, subject to reasonable conditions such as continued employment. 

         (i)    Termination of Continuous Service.    In the event an Optionholder's Continuous Service terminates (other than
upon the Optionholder's
death or Disability), the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination) but only within such
period of time ending on the earlier of (i) the date three (3) months following the termination of the Optionholder's Continuous Service (or such longer or shorter period specified in
the Option Agreement, which period shall not be less than thirty (30) days for Options granted prior to the Listing Date unless such termination is for Cause), or (ii) the expiration of
the term of the Option as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option within the time specified in the Option Agreement, the Option
shall terminate. 

        (j)    Extension of Termination Date.    An Optionholder's Option Agreement may also provide that if the exercise of
the Option following the
termination of the Optionholder's Continuous Service (other than upon the Optionholder's death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock
would violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of (i) the expiration of the term of the Option set forth in subsection 6(a)
or (ii) the expiration of a period of three (3) months after the termination of the Optionholder's Continuous Service during which the exercise of the Option would not be in violation of
such registration requirements. 

        (k)    Disability of Optionholder.    In the event that an Optionholder's Continuous Service terminates as a result of
the Optionholder's
Disability, the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date of termination), but only within such period of
time ending on the earlier of (i) the date twelve (12) months following such termination (or such longer or shorter period specified in the Option Agreement, which period shall not be
less than six (6) months for Options granted prior to the Listing Date) or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the
Optionholder does not exercise his or her Option within the time specified herein, the Option shall terminate. 

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         (l)    Death of Optionholder.    In the event (i) an Optionholder's Continuous Service terminates as a result of
the Optionholder's
death or (ii) the Optionholder dies within the period (if any) specified in the Option Agreement after the termination of the Optionholder's Continuous Service for a reason other than death,
then the Option may be exercised (to the extent the Optionholder was entitled to exercise such Option as of the date of death) by the Optionholder's estate, by a person who acquired the right to
exercise the Option by bequest or inheritance or by a person designated to exercise the option upon the Optionholder's death pursuant to subsection 6(e) or 6(f), but only within the period ending on
the earlier of (1) the date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement, which period shall not be less than six
(6) months for Options granted prior to the Listing Date) or (2) the expiration of the term of such Option as set forth in the Option Agreement. If, after death, the Option is not
exercised within the time specified herein, the Option shall terminate. 

         (m)    Early Exercise.    The Option may, but need not, include a provision whereby the Optionholder may elect at any
time before the
Optionholder's Continuous Service terminates to exercise the Option as to any part or all of the shares of Common Stock subject to the Option prior to the full vesting of the Option. Subject to the
"Repurchase Limitation" in subsection 10(h), any unvested shares of Common Stock so purchased may be subject to a repurchase option in favor of the Company or to any other restriction the Board
determines to be appropriate. 

         (n)    Right of Repurchase.    Subject to the "Repurchase Limitation" in subsection 10(h), the Option may, but need
not, include a provision
whereby the Company may elect, prior to the Listing Date, to repurchase all or any part of the vested shares of Common Stock acquired by the Optionholder pursuant to the exercise of the Option. 

        (o)    Right of First Refusal.    The Option may, but need not, include a provision whereby the Company may elect,
prior to the Listing Date,
to exercise a right of first refusal following receipt of notice from the Optionholder of the intent to transfer all or any part of the shares of Common Stock received upon the exercise of the Option.
Except as expressly provided in this subsection [6(o)], such right of first refusal shall otherwise comply with any applicable
provisions of the Bylaws of the Company. 

        7.    PROVISIONS OF STOCK AWARDS OTHER THAN OPTIONS.    

         (a)    Stock Bonus Awards.    Each stock bonus agreement shall be in such form and shall contain such terms and
conditions as the Board shall
deem appropriate. The terms and conditions of stock bonus agreements may change from time to time, and the terms and conditions of separate stock bonus agreements need not be identical, but each stock
bonus agreement shall include (through incorporation of provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions: 

          (i)  Consideration. A stock bonus may be awarded in consideration for past services actually rendered to the Company or an
Affiliate for its benefit. 

         (ii)  Vesting. Subject to the "Repurchase Limitation" in subsection 10(h), shares of Common Stock awarded under the stock
bonus agreement may, but need not, be subject to a share repurchase option in favor of the Company in accordance with a vesting schedule to be determined by the Board. 

       (iii)  Termination of Participant's Continuous Service. Subject to the "Repurchase Limitation" in subsection 10(h), in the
event a Participant's Continuous Service terminates, the Company may reacquire any or all of the shares of Common Stock held by the Participant which have not vested as of the date of termination
under the terms of the stock bonus agreement. 

10

 

        (iv)  Transferability. For a stock bonus award made before the Listing Date, rights to acquire shares of Common Stock under
the stock bonus agreement shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Participant only by the Participant.
For a stock bonus award made on or after the Listing Date, rights to acquire shares of Common Stock under the stock bonus agreement shall be transferable by the Participant only upon such terms and
conditions as are set forth in the stock bonus agreement, as the Board shall determine in its discretion, so long as Common Stock awarded under the stock bonus agreement remains subject to the terms
of the stock bonus agreement. 

         (b)    Restricted Stock Awards.    Each restricted stock purchase agreement shall be in such form and shall contain
such terms and conditions
as the Board shall deem appropriate. The terms and conditions of the restricted stock purchase agreements may change from time to time, and the terms and conditions of separate restricted stock
purchase agreements need not be identical, but each restricted stock purchase agreement shall include (through incorporation of provisions hereof by reference in the agreement or otherwise) the
substance of each of the following provisions: 

          (i)  Purchase Price. Subject to the provisions of subsection 5(b) regarding Ten Percent Stockholders, the purchase price
under each restricted stock purchase agreement shall be such amount as the Board shall determine and designate in such restricted stock purchase agreement. For restricted stock awards made prior to
the Listing Date, the purchase price shall not be less than eighty-five percent (85%) of the Common Stock's Fair Market Value on the date such award is made or at the time the purchase is
consummated. For restricted stock awards made on or after the Listing Date, the purchase price shall not be less than eighty-five percent (85%) of the Common Stock's Fair Market Value on
the date such award is made or at the time the purchase is consummated. 

         (ii)  Consideration. The purchase price of Common Stock acquired pursuant to the restricted stock purchase agreement shall be
paid either: (i) in cash at the time of purchase; (ii) at the discretion of the Board, according to a deferred payment or other similar arrangement with the Participant; or
(iii) in any other form of legal consideration that may be acceptable to the Board in its discretion; provided, however, that at any time that the Company is incorporated in Delaware, then
payment of the Common Stock's "par value," as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 

       (iii)  Vesting. Subject to the "Repurchase Limitation" in subsection 10(h), shares of Common Stock acquired under the
restricted stock purchase agreement may, but need not, be subject to a share repurchase option in favor of the Company in accordance with a vesting schedule to be determined by the Board. 

        (iv)  Termination of Participant's Continuous Service. Subject to the "Repurchase Limitation" in subsection 10(h), in the
event a Participant's Continuous Service terminates, the Company may repurchase or otherwise reacquire any or all of the shares of Common Stock held by the Participant which have not vested as of the
date of termination under the terms of the restricted stock purchase agreement. 

         (v)  Transferability. For a restricted stock award made before the Listing Date, rights to acquire shares of Common Stock
under the restricted stock purchase agreement shall not be transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Participant only
by the Participant. For a restricted stock award made on or after the Listing Date, rights to acquire shares of Common Stock under the restricted stock purchase agreement shall be transferable by the
Participant only upon such terms and conditions as are set forth in the restricted stock purchase agreement, as the Board 

11

 

shall
determine in its discretion, so long as Common Stock awarded under the restricted stock purchase agreement remains subject to the terms of the restricted stock purchase agreement. 

        8.    COVENANTS OF THE COMPANY.    

         (a)    Availability of Shares.    During the terms of the Stock Awards, the Company shall keep available at all times
the number of shares of
Common Stock required to satisfy such Stock Awards. 

         (b)    Securities Law Compliance.    The Company shall seek to obtain from each regulatory commission or agency having
jurisdiction over the
Plan such authority as may be required to grant Stock Awards and to issue and sell shares of Common Stock upon exercise of the Stock Awards; provided, however, that this undertaking shall not require
the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any such Stock Award. If, after reasonable efforts, the Company is unable
to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of Common Stock under the Plan, the Company shall
be relieved from any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. 

        9.    USE OF PROCEEDS FROM STOCK.    

        Proceeds
from the sale of Common Stock pursuant to Stock Awards shall constitute general funds of the Company. 

        10.    MISCELLANEOUS.    

         (a)    Acceleration of Exercisability and Vesting.    The Board shall have the power to accelerate the time at which a
Stock Award may first
be exercised or the time during which a Stock Award or any part thereof will vest in accordance with the Plan, notwithstanding the provisions in the Stock Award stating the time at which it may first
be exercised or the time during which it will vest. 

         (b)    Stockholder Rights.    No Participant shall be deemed to be the holder of, or to have any of the rights of a
holder with respect to,
any shares of Common Stock subject to such Stock Award unless and until such Participant has satisfied all requirements for exercise of the Stock Award pursuant to its terms. 

        (c)    No Employment or other Service Rights.    Nothing in the Plan or any instrument executed or Stock Award granted
pursuant thereto shall
confer upon any Participant any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Stock Award was granted or shall affect the right of the Company or an
Affiliate to terminate (i) the employment of an Employee with or without notice and with or without Cause, (ii) the service of a Consultant pursuant to the terms of such Consultant's
agreement with the Company or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the
state in which the Company or the Affiliate is incorporated, as the case may be. 

        (d)    Incentive Stock Option $100,000 Limitation.    To the extent that the aggregate Fair Market Value (determined at
the time of grant) of
Common Stock with respect to which Incentive Stock Options are exercisable for the first time by any Optionholder during any calendar year (under all plans of the Company and its Affiliates) exceeds
one hundred thousand dollars ($100,000), the Options or portions thereof which exceed such limit (according to the order in which they were granted) shall be treated as Nonstatutory Stock Options. 

12

 

         (e)    Investment Assurances.    The Company may require a Participant, as a condition of exercising or acquiring
Common Stock under any Stock
Award, (i) to give written assurances satisfactory to the Company as to the Participant's knowledge and experience in financial and business matters and/or to employ a purchaser representative
reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of evaluating, alone or together with the purchaser
representative, the merits and risks of exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Participant is acquiring Common Stock
subject to the Stock Award for the Participant's own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and any assurances
given pursuant to such requirements, shall be inoperative if (1) the issuance of the shares of Common Stock upon the exercise or acquisition of Common Stock under the Stock Award has been
registered under a then currently effective registration statement under the Securities Act or (2) as to
any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in the circumstances under the then applicable securities laws. The Company may,
upon advice of counsel to the Company, place legends on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws,
including, but not limited to, legends restricting the transfer of the Common Stock. 

         (f)    Withholding Obligations.    To the extent provided by the terms of a Stock Award Agreement, the Participant may
satisfy any federal,
state or local tax withholding obligation relating to the exercise or acquisition of Common Stock under a Stock Award by any of the following means (in addition to the Company's right to withhold from
any compensation paid to the Participant by the Company) or by a combination of such means: (i) tendering a cash payment; (ii) authorizing the Company to withhold shares of Common Stock
from the shares of Common Stock otherwise issuable to the Participant as a result of the exercise or acquisition of Common Stock under the Stock Award, provided, however, that no shares of Common
Stock are withheld with a value exceeding the minimum amount of tax required to be withheld by law; or (iii) delivering to the Company owned and unencumbered shares of Common Stock. 

         (g)    Information Obligation.    Prior to the Listing Date, to the extent required by Section 260.140.46 of
Title 10 of the California
Code of Regulations, the Company shall deliver financial statements to Participants at least annually. This subsection 10(g) shall not apply to key Employees whose duties in connection with the
Company assure them access to equivalent information. 

         (h)    Repurchase Limitation.    The terms of any repurchase option shall be specified in the Stock Award and may be
either at Fair Market
Value at the time of repurchase or at not less than the original purchase price. To the extent required by Section 260.140.41 and Section 260.140.42 of Title 10 of the California Code of
Regulations at the time a Stock Award is made, any repurchase option contained in a Stock Award granted prior to the Listing Date to a person who is not an Officer, Director or Consultant shall be
upon the terms described below: 

          (i)  Fair Market Value. If the repurchase option gives the Company the right to repurchase the shares of Common Stock upon
termination of employment at not less than the Fair Market Value of the shares of Common Stock to be purchased on the date of termination of Continuous Service, then (i) the right to repurchase
shall be exercised for cash or cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of termination of Continuous Service (or in the case of shares
of Common Stock issued upon exercise of Stock Awards after such date of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the
Company and the Participant (for example, for purposes of satisfying the requirements of Section 1202(c)(3) 

13

 

of
the Code regarding "qualified small business stock") and (ii) the right terminates when the shares of Common Stock become publicly traded. 

         (ii)  Original Purchase Price. If the repurchase option gives the Company the right to repurchase the shares of Common Stock
upon termination of Continuous Service at the original purchase price, then (i) the right to repurchase at the original purchase price shall lapse at the rate of at least twenty percent (20%)
of the shares of Common Stock per year over five (5) years from the date the Stock Award is granted (without respect to the date the Stock Award was exercised or became exercisable) and
(ii) the right to repurchase shall be exercised for cash or cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of termination of
Continuous Service (or in the case of shares of Common Stock issued upon exercise of Options after such date of termination, within ninety (90) days after the date of the exercise) or such
longer period as may be agreed to by the Company and the Participant (for example, for purposes of satisfying the requirements of Section 1202(c)(3) of the Code regarding "qualified small
business stock"). 

        11.    ADJUSTMENTS UPON CHANGES IN STOCK.    

         (a)    Capitalization Adjustments.    If any change is made in the Common Stock subject to the Plan, or subject to any
Stock Award, without
the receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split,
liquidating dividend, combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company) (individually, a
"Capitalization Adjustment"), the Plan will be appropriately adjusted in the class(es) and maximum number of securities subject to the Plan pursuant to subsection 4(a) and the maximum number of
securities subject to award to any person pursuant to subsection 5(c), and the outstanding Stock Awards will be appropriately adjusted in the class(es) and number of securities and price per share of
Common Stock subject to such outstanding Stock Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. (The conversion of any convertible
securities of the Company shall not be treated as a transaction "without receipt of consideration" by the Company.) 

         (b)    Dissolution or Liquidation.    In the event of a dissolution or liquidation of the Company, then all
outstanding Stock Awards shall
terminate immediately prior to such event. 

         (c)    Asset Sale, Merger, Consolidation or Reverse Merger.    In the event of (i) a sale, lease or other
disposition of all or
substantially all of the assets of the Company, (ii) a merger or consolidation in which the Company is not the surviving corporation or (iii) a reverse merger in which the Company is the
surviving corporation but the shares of Common Stock outstanding immediately preceding the merger are converted by virtue of the merger into other property, whether in the form of securities, cash or
otherwise (individually, a "Corporate Transaction"), then any surviving corporation or acquiring corporation shall assume any Stock Awards outstanding under the Plan or shall substitute similar stock
awards (including an award to acquire the same consideration paid to the stockholders in the Corporate Transaction for those outstanding under the Plan). In the event any surviving corporation or
acquiring corporation refuses to assume such Stock Awards or to substitute similar stock awards for those outstanding under the Plan, then with respect to Stock Awards held by Participants whose
Continuous Service has not terminated, the vesting of such Stock Awards (and, if applicable, the time during which such Stock Awards may be exercised) shall be accelerated in full, and the Stock
Awards shall terminate if not exercised (if applicable) at or prior to the Corporate Transaction. With respect to any other Stock Awards outstanding under the Plan, such Stock Awards shall terminate
if not exercised (if applicable) prior to the Corporate Transaction. In addition to the foregoing, a Stock Award held by any Participant whose Continuous Service has not terminated as of the effective
date of a Change in Control may 

14

 

be
subject to additional acceleration of vesting and exercisability as set forth in such Stock Award or as set forth in any other applicable written agreement between the Participant and the Company
or any Affiliate. 

         (d)    Change in Control.    Notwithstanding any other provisions of the Plan to the contrary, if (i) a Change in
Control occurs and
(ii) within the period beginning as of the effective date of such Change in Control and ending thirteen (13) months after the effective date of such Change in Control the Participant's
Continuous Service terminates due to an involuntary termination (not including death or Disability) without Cause or due to a voluntary termination with Good Reason, then, as of the date of
termination of the Participant's Continuous Service, the vesting and exercisability of the Participant's Stock Awards shall be accelerated in full (and any reacquisition or repurchase rights held by
the Company with respect to the shares of Common Stock subject to such Stock Awards shall lapse in full, as appropriate); provided, however, that if
such potential acceleration of the vesting and exercisability of the Participant's Stock Awards (or lapse of reacquisition or repurchase rights held by the Company with respect to the shares of Common
Stock subject to such Stock Awards) would cause a contemplated Change in Control transaction that is intended to be accounted for as a "pooling-of-interests" transaction to
become ineligible for such accounting treatment under generally accepted accounting principles as determined by the Company's independent certified public accountants prior to the Change in Control,
such acceleration shall not occur. 

         (e)    Parachute Payments.    If any payment or benefit the Participant would receive pursuant to a Change in Control
from the Company or
otherwise ("Payment") would (i) constitute a "parachute payment" within the meaning of Section 280G of the Code, and (ii) but for this sentence, be subject to the excise tax
imposed by Section 4999 of the Code (the "Excise Tax"), then such Payment shall be reduced to the Reduced Amount. The "Reduced Amount" shall be either (x) the largest portion of the
Payment that would result in no portion of the Payment being subject to the Excise Tax or (y) the largest portion, up to and including the total, of the Payment, whichever amount, after taking
into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate), results in such Participant's receipt,
on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in payments or benefits
constituting "parachute payments" is necessary so that the Payment equals the Reduced Amount, reduction shall occur in the following order unless the Participant elects in writing a different order
(provided, however, that such election shall be subject to Company approval if made on or after the effective date of the event that triggers the
Payment): reduction of cash payments; cancellation of accelerated vesting of Stock Awards; reduction of employee benefits. In the event that acceleration of vesting of Stock Award compensation is to
be reduced, such acceleration of vesting shall be cancelled in the reverse order of the date of grant of the Participant's Stock Awards unless the Participant elects in writing a different order for
cancellation. 

        The
accounting firm engaged by the Company for general audit purposes as of the day prior to the effective date of the Change in Control shall perform the foregoing calculations. If the
accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the Change in Control, the Company shall appoint a nationally recognized
accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required to be made hereunder. 

        The
accounting firm engaged to make the determinations hereunder shall provide its calculations, together with detailed supporting documentation, to the Company and the Participant
within fifteen (15) calendar days after the date on which the Participant's right to a Payment is triggered (if requested at that time by the Company or the Participant) or such other time as
requested by the Company or 

15

 

the
Participant. If the accounting firm determines that no Excise Tax is payable with respect to a Payment, either before or after the application of the Reduced Amount, it shall furnish the Company
and the Participant with an opinion reasonably acceptable to the Participant that no Excise Tax will be imposed with respect to such Payment. Any good faith determinations of the accounting firm made
hereunder shall be final, binding and conclusive upon the Company and the Participant. 

        12.    AMENDMENT OF THE PLAN AND STOCK AWARDS.    

        (a)    Amendment of Plan.    The Board at any time, and from time to time, may amend the Plan. However, except as
provided in
Section 11 relating to adjustments upon changes in Common Stock, no amendment shall be effective unless approved by the stockholders of the Company to the extent stockholder approval is
necessary to satisfy the requirements of Section 422 of the Code, Rule 16b-3 or any Nasdaq or securities exchange listing requirements. 

         (b)    Stockholder Approval.    The Board may, in its sole discretion, submit any other amendment to the Plan for
stockholder approval,
including, but not limited to, amendments to the Plan intended to satisfy the requirements of Section 162(m) of the Code and the regulations thereunder regarding the exclusion of
performance-based compensation from the limit on corporate deductibility of compensation paid to certain executive officers. 

         (c)    Contemplated Amendments.    It is expressly contemplated that the Board may amend the Plan in any respect the
Board deems necessary or
advisable to provide eligible Employees with the maximum benefits provided or to be provided under the provisions of the Code and the regulations promulgated thereunder relating to Incentive Stock
Options and/or to bring the Plan and/or Incentive Stock Options granted under it into compliance therewith. 

        (d)    No Impairment of Rights.    Rights under any Stock Award granted before amendment of the Plan shall not be
impaired by any amendment of
the Plan unless (i) the Company requests the consent of the Participant and (ii) the Participant consents in writing. 

         (e)    Amendment of Stock Awards.    The Board at any time, and from time to time, may amend the terms of any one or
more Stock Awards;
provided, however, that the rights under any Stock Award shall not be impaired by any such amendment unless (i) the Company requests the consent of the Participant and (ii) the
Participant consents in writing. 

        13.    TERMINATION OR SUSPENSION OF THE PLAN.    

         (a)    Plan Term.    The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall
terminate on the day
before the tenth (10th) anniversary of the date the Plan is adopted by the Board or approved by the stockholders of the Company, whichever is earlier. No Stock Awards may be granted under the Plan
while the Plan is suspended or after it is terminated. 

        (b)    No Impairment of Rights.    Suspension or termination of the Plan shall not impair rights and obligations under
any Stock Award granted
while the Plan is in effect except with the written consent of the Participant. 

        14.    EFFECTIVE DATE OF PLAN.    

        The
Plan shall become effective as determined by the Board, but no Stock Award shall be exercised (or, in the case of a stock bonus, shall be granted) unless and until the Plan has been
approved by the stockholders of the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 

        15.    CHOICE OF LAW.    

        The
law of the State of California shall govern all questions concerning the construction, validity and interpretation of this Plan, without regard to such state's conflict of laws
rules. 

16

   GENOPTIX, INC.

2001 EQUITY INCENTIVE PLAN

STOCK OPTION AGREEMENT

(INCENTIVE STOCK OPTION OR NONSTATUTORY STOCK OPTION)  

        Pursuant to your Stock Option Grant Notice ("Grant Notice") and this Stock Option Agreement, Genoptix, Inc. (the "Company") has granted you an option under
its 2001 Equity Incentive Plan (the "Plan") to purchase the number of shares of the Company's Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Defined
terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan. 

        The
details of your option are as follows: 

        1.    VESTING.    Subject to the limitations contained herein, your option will vest as provided in your Grant Notice,
provided that vesting will cease upon the termination of your Continuous Service. 

        2.    NUMBER OF SHARES AND EXERCISE PRICE.    The number of shares of Common Stock subject to your option and your
exercise price per share referenced in your Grant Notice may be adjusted from time to time for Capitalization Adjustments, as provided in the Plan. 

        3.    EXERCISE PRIOR TO VESTING ("EARLY EXERCISE").    If permitted in your Grant Notice (i.e., the "Exercise
Schedule" indicates that "Early Exercise" of your option is permitted) and subject to the provisions of your option, you may elect at any time that is both (i) during the period of your
Continuous Service and (ii) during the term of your option, to exercise all or part of your option, including the nonvested portion of your option; provided, however, that: 

        (a)   a partial exercise of your option shall be deemed to cover first vested shares of Common Stock and then the earliest
vesting installment of unvested shares of Common Stock; 

        (b)   any shares of Common Stock so purchased from installments that have not vested as of the date of exercise shall be
subject to the purchase option in favor of the Company as described in the Company's form of Early Exercise Stock Purchase Agreement; 

        (c)   you shall enter into the Company's form of Early Exercise Stock Purchase Agreement with a vesting schedule that will
result in the same vesting as if no early exercise had occurred; and 

        (d)   if your option is an incentive stock option, then, as provided in the Plan, to the extent that the aggregate Fair Market
Value (determined at the time of grant) of the shares of Common Stock with respect to which your option plus all other incentive stock options you hold are exercisable for the first time by you during
any calendar year (under all plans of the Company and its Affiliates) exceeds one hundred thousand dollars ($100,000), your option(s) or portions thereof that exceed such limit (according to the order
in which they were granted) shall be treated as nonstatutory stock options. 

        4.    METHOD OF PAYMENT.    Payment of the exercise price is due in full upon exercise of all or any part of your
option. You may elect to make payment of the exercise price in cash or by check or in any other manner permitted by your Grant Notice, which may include
one or more of the following: 

        (a)   In the Company's sole discretion at the time your option is exercised and provided that at the time of exercise the
Common Stock is publicly traded and quoted regularly in The Wall Street Journal, pursuant to a program developed under Regulation T as
promulgated by the Federal Reserve Board that, prior to the issuance of Common Stock, results in either the receipt of cash (or check) by the Company or the receipt of irrevocable instructions to pay
the aggregate exercise price to the Company from the sales proceeds. 

        (b)   Provided that at the time of exercise the Common Stock is publicly traded and quoted regularly in  The Wall Street Journal, by delivery of
already-owned shares of Common Stock either that you have held for the period required to avoid a charge to the
Company's reported earnings 

1

 

(generally
six months) or that you did not acquire, directly or indirectly from the Company, that are owned free and clear of any liens, claims, encumbrances or security interests, and that are valued
at Fair Market Value on the date of exercise. "Delivery" for these purposes, in the sole discretion of the Company at the time you exercise your option, shall include delivery to the Company of your
attestation of ownership of such shares of Common Stock in a form approved by the Company. Notwithstanding the foregoing, you may not exercise your option by tender to the Company of Common Stock to
the extent such tender would violate the provisions of any law, regulation or agreement restricting the redemption of the Company's stock. 

        5.    WHOLE SHARES.    You may exercise your option only for whole shares of Common Stock. 

        6.    SECURITIES LAW COMPLIANCE.    Notwithstanding anything to the contrary contained herein, you may not exercise
your option unless the shares of Common Stock issuable upon such exercise are then registered under the Securities Act or, if such shares of Common Stock are not then so registered, the Company has
determined that such exercise and issuance would be exempt from the registration requirements of the Securities Act. The exercise of your option must also comply with other applicable laws and
regulations governing your option, and you may not exercise your option if the Company determines that such exercise would not be in material compliance with such laws and regulations. 

        7.    TERM.    You may not exercise your option before the commencement of its term or after its term expires. The
term of your option commences on the Date of Grant and expires upon the earliest of the following: 

        (a)   three (3) months after the termination of your Continuous Service for any reason other than your Disability or
death, provided that if during any part of such three- (3-) month period your option is not exercisable solely because of the condition set forth in the preceding paragraph relating to
"Securities Law Compliance," your option shall not expire until the earlier of the Expiration Date or until it shall have been exercisable for an aggregate period of three (3) months after the
termination of your Continuous Service; 

        (b)   twelve (12) months after the termination of your Continuous Service due to your Disability; 

        (c)   eighteen (18) months after your death if you die either during your Continuous Service or within three
(3) months after your Continuous Service terminates; 

        (d)   the Expiration Date indicated in your Grant Notice; or 

        (e)   the day before the tenth (10th) anniversary of the Date of Grant. 

        If
your option is an incentive stock option, note that, to obtain the federal income tax advantages associated with an "incentive stock option," the Code requires that at all times
beginning on the date of grant of your option and ending on the day three (3) months before the date of your option's exercise, you must be an employee of the Company or an Affiliate, except in
the event of your death or Disability. The Company has provided for extended exercisability of your option under certain circumstances for your benefit but cannot guarantee that your option will
necessarily be treated as an "incentive stock option" if you continue to provide services to the Company or an Affiliate as a
Consultant or Director after your employment terminates or if you otherwise exercise your option more than three (3) months after the date your employment terminates. 

        8.    EXERCISE.    

        (a)   You may exercise the vested portion of your option (and the unvested portion of your option if your Grant Notice so
permits) during its term by delivering a Notice of Exercise (in a form designated by the Company) together with the exercise price to the Secretary of the 

2

 

Company,
or to such other person as the Company may designate, during regular business hours, together with such additional documents as the Company may then require. 

        (b)   By exercising your option you agree that, as a condition to any exercise of your option, the Company may require you to
enter into an arrangement providing for the payment by you to the Company of any tax withholding obligation of the Company arising by reason of (1) the exercise of your option, (2) the
lapse of any substantial risk of forfeiture to which the shares of Common Stock are subject at the time of exercise, or (3) the disposition of shares of Common Stock acquired upon such
exercise. 

        (c)   If your option is an incentive stock option, by exercising your option you agree that you will notify the Company in
writing within fifteen (15) days after the date of any disposition of any of the shares of the Common Stock issued upon exercise of your option that occurs within two (2) years after the
date of your option grant or within one (1) year after such shares of Common Stock are transferred upon exercise of your option. 

        (d)   By exercising your option you agree that the Company (or a representative of the underwriter(s)) may, in connection with
the first underwritten registration of the offering of any securities of the Company under the Securities Act, require that you not sell, dispose of, transfer, make any short sale of, grant any option
for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale with respect to, any shares of Common Stock or other securities of the Company held by
you, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty (180) days) following the effective date of the registration statement of the Company filed under the
Securities Act. You further agree to execute and deliver such other agreements as may be reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that
are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to your shares of Common Stock
until the end of such period. The underwriters of the Company's stock are intended third party beneficiaries of this Section 8(d) and shall have the right, power and authority to enforce the
provisions hereof as though they were a party hereto. 

        9.    TRANSFERABILITY.    Your option is not transferable, except by will or by the laws of descent and distribution,
and is exercisable during your life only by you. Notwithstanding the foregoing, by delivering written notice to the Company, in a form satisfactory to the Company, you may designate a third party who,
in the event of your death, shall thereafter be entitled to exercise your option. 

        10.    RIGHT OF FIRST REFUSAL.    

        (a)   Shares of Common Stock that you acquire upon exercise of your option are subject to any right of first refusal that may
be described in the Company's bylaws in effect at such time the Company elects to exercise its right. 

        (b)   If there is no right of first refusal described in the Company's bylaws in effect at such time the Company elects to
exercise its right, then you may not validly transfer (as hereinafter defined) any of the shares of Common Stock that you acquire upon exercise of your option, or any interest in such shares, unless
such transfer is solely for cash consideration and is made in compliance with the following provisions (the Company's "Right of First Refusal"): 

          (i)  Before there can be a valid transfer of any shares or any interest therein, the record holder of the shares to be
transferred (the "Offered Shares") shall give written notice (by registered or certified mail) to the Company. Such notice shall specify the identity of the proposed transferee, the cash price offered
for the Offered Shares by the proposed transferee and the other terms and conditions of the proposed transfer. The date such notice is mailed shall be hereinafter referred to as the "notice date," and
the record holder of the Offered Shares shall be hereinafter referred to as the "Offeror." 

3

 

         (ii)  For a period of thirty (30) calendar days after the notice date, the Company shall have the option, but not the
obligation, to purchase all (or any part) of the Offered Shares at the purchase price and on the terms set forth in subsection 10(b)(iii). The Company may exercise its Right of First Refusal by
mailing (by registered or certified mail) written notice of exercise of its Right of First Refusal to the Offeror prior to the end of said thirty (30) days. 

       (iii)  The price at which the Company may purchase the Offered Shares pursuant to the exercise of its Right of First Refusal
shall be the cash price offered for the Offered Shares by the proposed transferee (as set forth in the notice required under subsection 10(b)(i)). The Company's notice of exercise of its Right of
First Refusal shall be accompanied by full payment for the Offered Shares and, upon such payment by the Company, the Company shall acquire full right, title and interest to all of the Offered Shares. 

        (iv)  If, and only if, the option given pursuant to subsection 10(b)(ii) is not exercised, the transfer proposed in the
notice given pursuant to subsection 10(b)(i) may take place; provided, however, that such transfer must, in all respects, be exactly as proposed in said notice except that such transfer may not
take place either before the tenth (10th) calendar day after the expiration of said 30-day option exercise period or after the ninetieth (90th) calendar day after the expiration of said
30-day option exercise period, and if such transfer has not taken place prior to said ninetieth (90th) day, such transfer may not take place without once again complying with this
subsection 10(b). 

         (v)  As used in this subsection 10(b), the term "transfer" means any sale, encumbrance, pledge, gift or other form of
disposition or transfer of shares of the Company's stock or any legal or equitable interest therein; provided, however, that the term "transfer" does not include a transfer of such shares or interests
by will or by the applicable laws of descent and distribution or a bona fide gift of such shares if the donee agrees to be bound by the provisions of this Stock Option Agreement. 

        (vi)  None of the shares of the Company's stock purchased upon exercise of your option shall be transferred on the Company's
books nor shall the Company recognize any such transfer of any such shares or any interest therein unless and until all applicable provisions of this subsection 10(b) have been complied with in all
respects. The certificates of stock evidencing shares of stock purchased upon exercise of your option shall bear an appropriate legend referring to the transfer restrictions imposed by this subsection
10(b). 

       (vii)  If, from time to time, there is any stock dividend, stock split or other change in the character or amount of any of
the outstanding stock of the corporation the stock of which is subject to the provisions of your option, then in such event any and all new, substituted or additional securities to which you are
entitled by reason of your ownership of the shares acquired under your option shall be immediately subject to the Company's Right of First Refusal with the same force and effect as the shares you
acquired pursuant to the exercise of your option. 

      (viii)  To ensure that shares subject to the Company's Right of First Refusal will be available for repurchase by the Company,
the Company may require you to deposit the certificate(s) evidencing the shares that you purchase upon exercise of your option with an escrow agent designated by the Company under the terms and
conditions of an escrow agreement approved by the Company. If the Company does not require such deposit as a condition of exercise of your option, the Company reserves the right at any time to require
you to so deposit the certificate(s) in escrow. As soon as practicable after the expiration of the Company's Right of First Refusal, the agent shall deliver to you the shares and any other property no
longer subject to such restriction. In the event the shares and any other property held in escrow are subject to the Company's exercise of its Right of First Refusal, the notices 

4

 

required
to be given to you shall be given to the escrow agent, and any payment required to be given to you shall be given to the escrow agent. Within thirty (30) days after payment by the
Company for the Offered Shares, the escrow agent shall deliver the Offered Shares that the Company has repurchased to the Company and shall deliver the payment received from the Company to you. 

        (c)   The Company's Right of First Refusal shall expire on the Listing Date. 

        11.    OPTION NOT A SERVICE CONTRACT.    Your option is not an employment or service contract, and nothing in your
option shall be deemed to create in any way whatsoever any obligation on your part to continue in the employ of the Company or an Affiliate, or of the Company or an Affiliate to continue your
employment. In addition, nothing in your option shall obligate the Company or an Affiliate, their respective stockholders, Boards of Directors, Officers or Employees to continue any relationship that
you might have as a Director or Consultant for the Company or an Affiliate. 

        12.    WITHHOLDING OBLIGATIONS.    

        (a)   At the time you exercise your option, in whole or in part, or at any time thereafter as requested by the Company, you
hereby authorize withholding from payroll and any other amounts payable to you, and otherwise agree to make adequate provision for (including by means of a "cashless exercise" pursuant to a program
developed under Regulation T as promulgated by the Federal Reserve Board to the extent permitted by the Company), any sums required to satisfy the federal, state, local and foreign tax
withholding obligations of the Company or an Affiliate, if any, which arise in connection with your option. 

        (b)   Upon your request and subject to approval by the Company, in its sole discretion, and compliance with any applicable
conditions or restrictions of law, the Company may withhold from fully vested shares of Common Stock otherwise issuable to you upon the exercise of your option a number of whole shares of Common Stock
having a Fair Market Value, determined by the Company as of the date of exercise, not in excess of the minimum amount of tax required to be withheld by law. If the date of
determination of any tax withholding obligation is deferred to a date later than the date of exercise of your option, share withholding pursuant to the preceding sentence shall not be permitted unless
you make a proper and timely election under Section 83(b) of the Code, covering the aggregate number of shares of Common Stock acquired upon such exercise with respect to which such
determination is otherwise deferred, to accelerate the determination of such tax withholding obligation to the date of exercise of your option. Notwithstanding the filing of such election, shares of
Common Stock shall be withheld solely from fully vested shares of Common Stock determined as of the date of exercise of your option that are otherwise issuable to you upon such exercise. Any adverse
consequences to you arising in connection with such share withholding procedure shall be your sole responsibility. 

        (c)   You may not exercise your option unless the tax withholding obligations of the Company and/or any Affiliate are
satisfied. Accordingly, you may not be able to exercise your option when desired even though your option is vested, and the Company shall have no obligation to issue a certificate for such shares of
Common Stock or release such shares of Common Stock from any escrow provided for herein. 

        13.    NOTICES.    Any notices provided for in your option or the Plan shall be given in writing and shall be deemed
effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five (5) days after deposit in the United States mail, postage prepaid, addressed to you at
the last address you provided to the Company. 

        14.    GOVERNING PLAN DOCUMENT.    Your option is subject to all the provisions of the Plan, the provisions of which
are hereby made a part of your option, and is further subject to all interpretations, amendments, rules and regulations which may from time to time be promulgated and adopted pursuant to the Plan. In
the event of any conflict between the provisions of your option and those of the Plan, the provisions of the Plan shall control. 

5

GENOPTIX, INC.

STOCK OPTION GRANT NOTICE

(2001 EQUITY INCENTIVE PLAN)

GENOPTIX, INC. (the "Company"), pursuant to its 2001 Equity Incentive Plan (the "Plan"), hereby grants to Optionholder an option to purchase the
number of shares of the Company's Common Stock set forth below. This option is subject to all of the terms and conditions as set forth herein and in the Stock Option Agreement, the Plan and the Notice
of Exercise, all of which are attached hereto and incorporated herein in their entirety. 

	Optionholder:	 	

	Date of Grant:	 	

	Vesting Commencement Date:	 	

	Number of Shares Subject to Option:	 	

	Exercise Price (Per Share):	 	

	Total Exercise Price:	 	

	Expiration Date:	 	

	Type of Grant:	 	o  Incentive Stock Option(1)	 	o  Nonstatutory Stock Option
	
Exercise Schedule:	
 	

[Same as Vesting Schedule]  [Early Exercise Permitted]
	
Vesting Schedule:	
 	

[1/4th of the shares vest one year after the Vesting Commencement Date.
	 	 	1/48th of the shares vest monthly thereafter over the next three years.]
	
Payment:	
 	

By one or a combination of the following items (described in the Stock Option Agreement):
	

 	
 	

               By cash or check

               Pursuant to a Regulation T Program if the Shares are publicly

               traded

               By delivery of already-owned shares if the Shares are publicly

               traded

               [By deferred payment]

Additional Terms/Acknowledgements: The undersigned Optionholder acknowledges receipt of, and understands and agrees to, this Grant Notice, the Stock
Option Agreement and the Plan. Optionholder further acknowledges that as of the Date of Grant, this Grant Notice, the Stock Option Agreement and the Plan set forth the entire understanding between
Optionholder and the Company regarding the acquisition of stock in the Company and supersede all prior oral and written agreements on that subject with the exception of (i) options previously
granted and delivered to Optionholder under the Plan, and (ii) the following agreements only: 

	          OTHER AGREEMENTS:	 	

	

 	
 	

	GENOPTIX, INC.	 	OPTIONHOLDER:
	

By:	
 	

 Signature	
 	

 Signature
	

Title:	
 	

	
 	

Date:	
 	

	

Date:	
 	

	
 	

 	
 	

 

ATTACHMENTS: (I) Stock Option Agreement, (II) 2001 Equity Incentive Plan and (III) Notice of Exercise 

	(1)
	If
this is an incentive stock option, it (plus your other outstanding incentive stock options) cannot be first  exercisable for more than $100,000 in any calendar year. Any excess over $100,000 is a
nonstatutory option. 

   NOTICE OF EXERCISE  

	Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121	 	Date of Exercise:	 	

Ladies
and Gentlemen: 

        This
constitutes notice under my stock option that I elect to purchase the number of shares for the price set forth below. 

	Type of option (check one):	 	Incentive  o	 	 	Nonstatutory  o
	

Stock option dated:	
 	

	

 	
 	

 
	

Number of shares as

to which option is

exercised:	
 	

	

 	
 	

 
	

Certificates to be

issued in name of:	
 	

	

 	
 	

 
	

Total exercise price:	
 	

$
	

 	
 	

 
	

Cash payment delivered

herewith:	
 	

$
	

 	
 	

 
	

[Promissory note delivered

herewith:	
 	

$
	

]	
 	

 
	

Value of            shares of

Genoptix, Inc. common

stock delivered herewith(1):	
 	

$
	

 	
 	

 

	(1)
	Shares
must meet the public trading requirements set forth in the option. Shares must be valued in accordance with the terms of the option being exercised, must have been owned for
the minimum period required in the option, and must be owned free and clear of any liens, claims, encumbrances or security interests. Certificates must be endorsed or accompanied by an executed
assignment separate from certificate. 

        By
this exercise, I agree (i) to provide such additional documents as you may require pursuant to the terms of the 2001 Equity Incentive Plan, (ii) to provide for the
payment by me to you (in the manner designated by you) of your withholding obligation, if any, relating to the exercise of this option, and (iii) if this exercise relates to an incentive stock
option, to notify you in writing within fifteen (15) days after the date of any disposition of any of the shares of Common Stock issued upon exercise of this option that occurs within two
(2) years after the date of grant of this option or within one (1) year after such shares of Common Stock are issued upon exercise of this option. 

1

 

        I
hereby make the following certifications and representations with respect to the number of shares of Common Stock of the Company listed above (the "Shares"), which are being acquired
by me for my own account upon exercise of the Option as set forth above: 

        I
acknowledge that the Shares have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), and are deemed to constitute "restricted securities" under
Rule 701 and "control securities" under Rule 144 promulgated under the Securities Act. I warrant and represent to the Company that I have no present intention of distributing or selling
said Shares, except as permitted under the Securities Act and any applicable state securities laws. 

        I
further acknowledge that I will not be able to resell the Shares for at least ninety (90) days after the stock of the Company becomes publicly traded
(i.e., subject to the reporting requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934) under Rule 701 and that more
restrictive conditions apply to affiliates of the Company under Rule 144. 

        I
further acknowledge that all certificates representing any of the Shares subject to the provisions of the Option shall have endorsed thereon appropriate legends reflecting the
foregoing limitations, as well as any legends reflecting restrictions pursuant to the Company's Certificate of Incorporation, Bylaws and/or applicable securities laws. 

        I
further agree that, if required by the Company (or a representative of the underwriters) in connection with the first underwritten registration of the offering of any securities of the
Company under the Securities Act, I will not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale with respect to, any Shares or other securities of the Company held by me, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty
(180) days) following the effective date of the registration statement of the Company filed under the Securities Act. I further agree to execute and deliver such other agreements as may be
reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary to give further effect thereto.
In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to my Shares until the end of such period. 

	 	 	Very truly yours,
	

 	
 	

2

GENOPTIX, INC.  

EARLY EXERCISE STOCK PURCHASE AGREEMENT

UNDER THE 2001 EQUITY INCENTIVE PLAN  

        THIS AGREEMENT is made by and between GENOPTIX, INC., a
Delaware corporation (the "Company"), and                        ("Purchaser"). 

WITNESSETH:  

        WHEREAS, Purchaser holds a stock option
dated                        to purchase shares of common stock ("Common Stock")
of the Company (the "Option") pursuant to the Company's 2001 Equity Incentive Plan (the "Plan"); and 

        WHEREAS, the Option consists of a Stock Option Grant Notice and a Stock Option Agreement; and 

        WHEREAS, Purchaser desires to exercise the Option on the terms and conditions contained herein; and 

        WHEREAS, Purchaser wishes to take advantage of the early exercise provision of the Purchaser's Option and therefore to enter into this
Agreement; 

        NOW, THEREFORE, IT IS AGREED between the parties as follows: 

        1.    INCORPORATION OF PLAN AND OPTION BY REFERENCE.    This Agreement is subject to all of the terms and conditions
as set forth in the Plan and the Option. If there is a conflict between the terms of this Agreement and/or the Option and the terms of the Plan, the terms of the Plan shall control. If there is a
conflict between the terms of this Agreement and the terms of the Option, the terms of the Option shall control. Defined terms not explicitly defined in this Agreement but defined in
the Plan shall have the same definitions as in the Plan. Defined terms not explicitly defined in this Agreement or the Plan but defined in the Option shall have the same definitions as in the Option. 

        2.    PURCHASE AND SALE OF COMMON STOCK.    

         (a)    Agreement to Purchase and Sell Common Stock.    Purchaser hereby agrees to purchase from the Company, and the
Company hereby agrees to
sell to Purchaser, shares of the Common Stock of the Company in accordance with the Notice of Exercise duly executed by Purchaser and attached hereto as Exhibit A. 

         (b)    Closing.    The closing hereunder, including payment for and delivery of the Common Stock, shall occur at the
offices of the Company
immediately following the execution of this Agreement, or at such other time and place as the parties may mutually agree; provided, however, that if
stockholder approval of the Plan is required before the Option may be exercised, then the Option may not be exercised, and the closing shall be delayed, until such stockholder approval is obtained. If
such stockholder approval is not obtained within the time limit specified in the Plan, then this Agreement shall be null and void. 

        3.    UNVESTED SHARE REPURCHASE OPTION.    

         (a)    Repurchase Option.    In the event Purchaser's Continuous Service terminates, then the Company shall have an
irrevocable option (the
"Repurchase Option") for a period of ninety (90) days after said termination (or in the case of shares issued upon exercise of the Option after such date of termination, within ninety
(90) days after the date of the exercise), or such longer period as may be agreed to by the Company and the Purchaser, to repurchase from Purchaser or Purchaser's personal representative, as
the case may be, those shares that Purchaser received pursuant to the exercise of the Option that have not as yet vested as of such termination date in accordance with the Vesting Schedule indicated
on Purchaser's Stock Option Grant Notice (the "Unvested Shares"). 

 

         (b)    Shares Repurchasable at Purchaser's Original Exercise Price.    The Company may repurchase all or any of the
Unvested Shares at a price
("Option Price") equal to the Purchaser's Exercise Price for such shares as indicated on Purchaser's Stock Option Grant Notice. 

        4.    EXERCISE OF REPURCHASE OPTION.    The Repurchase Option shall be exercised by written notice signed by an
officer of the Company and delivered or mailed as provided herein. Such notice shall identify the number of shares of Common Stock to be purchased and shall notify Purchaser of the time, place and
date for settlement of such purchase, which shall be scheduled by the Company within the term of the Repurchase Option set forth above. The Company shall be entitled to pay for any shares of Common
Stock purchased pursuant to its Repurchase Option at the Company's option in cash or by offset against any indebtedness owing to the Company by Purchaser (including without limitation any Note given
in payment for the Common Stock), or by a combination of both. Upon delivery of such notice and payment of the purchase price in any of the ways described above, the Company shall become the legal and
beneficial owner of the Common Stock being repurchased and all rights and interest therein or related thereto, and the Company shall have the right to transfer to its own name the Common Stock being
repurchased by the Company, without further action by Purchaser. 

        5.    CAPITALIZATION ADJUSTMENTS TO COMMON STOCK.    In the event of a "Capitalization Adjustment" affecting the
Company's outstanding Common Stock as a class as designated in the Plan, then any and all new, substituted or additional securities or other property to which Purchaser is entitled by reason of
Purchaser's ownership of Common Stock shall be immediately subject to the Repurchase Option and be included in the word "Common Stock" for all purposes of the Repurchase Option with the same force and
effect as the shares of the Common Stock presently subject to the Repurchase Option, but only to the extent the Common Stock is, at the time, covered by such Repurchase Option. While the total Option
Price shall remain the same after each such event, the Option Price per share of Common Stock upon exercise of the Repurchase Option shall be appropriately adjusted. 

        6.    CORPORATE TRANSACTIONS.    In the event of a Corporate Transaction described in subsection 11(c) of the Plan,
then the Repurchase Option may be assigned by the Company to the successor of the Company (or such successor's parent company), if any, in connection with such Corporate Transaction. To the extent the
Repurchase Option remains in effect following such Corporate Transaction, it shall apply to the new capital stock or other property received in exchange for the Common Stock in consummation of the
Corporate Transaction, but only to the extent the Common Stock was at the time covered by such right. Appropriate adjustments shall be made to the price per share payable upon exercise of the
Repurchase Option to reflect the Corporate Transaction upon the Company's capital structure; provided, however, that the aggregate Option Price shall remain the same. 

        7.    ESCROW OF UNVESTED COMMON STOCK.    As security for Purchaser's faithful performance of the terms of this
Agreement and to insure the availability for delivery of Purchaser's Common Stock upon exercise of the Repurchase Option herein provided for, Purchaser agrees, at the closing hereunder, to deliver to
and deposit with the Secretary of the Company or the Secretary's designee ("Escrow Agent"), as Escrow Agent in this transaction, three (3) stock assignments duly endorsed (with date and number
of shares blank) in the form attached hereto as Exhibit B, together with a certificate or certificates evidencing all of the Common Stock subject to the Repurchase Option; said documents are to
be held by the Escrow Agent and delivered by said Escrow Agent pursuant to the Joint Escrow
Instructions of the Company and Purchaser set forth in Exhibit C, attached hereto and incorporated by this reference, which instructions shall also be delivered to the Escrow Agent at the
closing hereunder. 

        8.    RIGHTS OF PURCHASER.    Subject to the provisions of the Option, Purchaser shall exercise all rights and
privileges of a stockholder of the Company with respect to the shares deposited in escrow. Purchaser shall be deemed to be the holder of the shares for purposes of receiving any 

2

 

dividends
that may be paid with respect to such shares and for purposes of exercising any voting rights relating to such shares, even if some or all of such shares have not yet vested and been
released from the Company's Repurchase Option. 

        9.    LIMITATIONS ON TRANSFER.    In addition to any other limitation on transfer created by applicable securities
laws, Purchaser shall not sell, assign, hypothecate, donate, encumber or otherwise dispose of any interest in the Common Stock while the Common Stock is subject to the Repurchase Option. After any
Common Stock has been released from the Repurchase Option, Purchaser shall not sell, assign, hypothecate, donate, encumber or otherwise dispose of any interest in the Common Stock except in compliance
with the provisions herein and applicable securities laws. Furthermore, the Common Stock shall be subject to any right of first refusal in favor of the Company or its assignees that may be contained
in the Company's Bylaws. 

        10.    RESTRICTIVE LEGENDS.    All certificates representing the Common Stock shall have endorsed thereon legends in
substantially the following forms (in addition to any other legend which may be required by other agreements between the parties hereto): 

        (a)   "THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO AN OPTION SET FORTH IN AN AGREEMENT BETWEEN THE COMPANY AND
THE REGISTERED HOLDER, OR SUCH HOLDER'S PREDECESSOR IN INTEREST, A COPY OF WHICH IS ON FILE AT THE PRINCIPAL OFFICE OF THIS COMPANY. ANY TRANSFER OR ATTEMPTED TRANSFER OF ANY SHARES SUBJECT TO SUCH
OPTION IS VOID WITHOUT THE PRIOR EXPRESS WRITTEN CONSENT OF THE COMPANY." 

        (b)   "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 AS AMENDED. THEY
MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED." 

        (c)   "THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A RIGHT OF FIRST REFUSAL OPTION IN FAVOR OF THE COMPANY AND/OR
ITS ASSIGNEE(S) AS PROVIDED IN THE COMPANY'S STOCK OPTION AGREEMENT." 

        (d)   Any legend required by appropriate blue sky officials. 

        11.    INVESTMENT REPRESENTATIONS.    In connection with the purchase of the Common Stock, Purchaser represents to the
Company the following: 

        (a)   Purchaser is aware of the Company's business affairs and financial condition and has acquired sufficient information
about the Company to reach an informed and knowledgeable decision to acquire the Common Stock. Purchaser is acquiring the Common Stock for investment for Purchaser's own account only and not with a
view to, or for resale in connection with, any "distribution" thereof within the meaning of the Securities Act. 

        (b)   Purchaser understands that the Common Stock has not been registered under the Securities Act by reason of a specific
exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Purchaser's investment intent as expressed herein. 

        (c)   Purchaser further acknowledges and understands that the Common Stock must be held indefinitely unless the Common Stock is
subsequently registered under the Securities Act or an exemption from such registration is available. Purchaser further acknowledges and understands that the Company is under no obligation to register
the Common Stock. Purchaser understands that the certificate evidencing the Common Stock will be imprinted with a legend that prohibits the transfer 

3

 

of
the Common Stock unless the Common Stock is registered or such registration is not required in the opinion of counsel for the Company. 

        (d)   Purchaser is familiar with the provisions of Rules 144 and 701, under the Securities Act, as in effect from time
to time, which, in substance, permit limited public resale of "restricted securities" acquired, directly or indirectly, from the issuer thereof (or from an affiliate of such issuer), in a
non-public offering subject to the satisfaction of certain conditions. Rule 701 provides that if the issuer qualifies under Rule 701 at the time of issuance of the
securities, such issuance will be exempt from registration under the Securities Act. In the event the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, the securities exempt under Rule 701 may be sold by Purchaser ninety (90) days thereafter, subject to the satisfaction of certain of the conditions
specified by Rule 144 and the market stand-off provision described in Purchaser's Stock Option Agreement. 

        (e)   In the event that the sale of the Common Stock does not qualify under Rule 701 at the time of purchase, then the
Common Stock may be resold by Purchaser in certain limited circumstances subject to the provisions of Rule 144, which requires, among other things: (i) the availability of certain public
information about the Company and (ii) the resale occurring following the required holding period under Rule 144 after the Purchaser has purchased, and made full payment of (within the
meaning of Rule 144), the securities to be sold. 

        (f)    Purchaser further understands that at the time Purchaser wishes to sell the Common Stock there may be no public market
upon which to make such a sale, and that, even if such a public market then exists, the Company may not be satisfying the current public current information requirements of Rule 144 or 701, and
that, in such event, Purchaser would be precluded from selling the Common Stock under Rule 144 or 701 even if the minimum holding period requirement had been satisfied. 

        (g)   Purchaser further warrants and represents that Purchaser has either (i) preexisting personal or business
relationships, with the Company or any of its officers, directors or controlling persons, or (ii) the capacity to protect his own interests in connection with the purchase of the Common Stock
by virtue of the business or financial expertise of the Purchaser or of professional advisors to Purchaser who are unaffiliated with and who are not compensated by the Company or any of its
affiliates, directly or indirectly. 

        12.    MARKET STAND-OFF AGREEMENT.    By exercising the Option Purchaser agrees that the Company (or a
representative of the underwriters) may, in connection with any underwritten registration of the offering of any securities of the Company under the Securities Act, require that the Purchaser not
sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale with respect to, any
shares of Common Stock or other securities of the Company held by Purchaser, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty (180) days) following the
effective date of the registration statement of the Company filed under the Securities Act. Purchaser further agrees to execute and deliver such other agreements as may be reasonably requested by the
Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary to give further effect thereto. In order to enforce the foregoing covenant, the Company may impose
stop-transfer instructions with respect to Purchaser's Common Stock until the end of such period. The underwriters of the Company's stock are intended third party beneficiaries of this
Section 12 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

        13.    SECTION 83(b) ELECTION.    Purchaser understands that Section 83(a) of the Code, taxes as
ordinary income the difference between the amount paid for the Common Stock and the fair market value of the Common Stock as of the date any restrictions on the Common Stock lapse. In this context, 

4

 

"restriction"
includes the right of the Company to buy back the Common Stock pursuant to the Repurchase Option set forth above. Purchaser understands that Purchaser may elect to be taxed at the time
the Common Stock is purchased, rather than when and as the Repurchase Option expires, by filing an election under Section 83(b) (an "83(b) Election") of the Code with the Internal Revenue
Service within thirty (30) days from the date of purchase. Even if the fair market value of the Common Stock at the time of the execution of this Agreement equals the amount paid for the Common
Stock, the 83(b) Election must be made to avoid income under Section 83(a) in the future. Purchaser understands that failure to file such an 83(b) Election in a timely manner may result in
adverse tax consequences for Purchaser. Purchaser further understands that Purchaser must file an additional copy of such 83(b) Election with his or her federal income tax return for the calendar year
in which the date of this Agreement falls. Purchaser acknowledges that the foregoing is only a summary of the effect of United States federal income taxation with respect to purchase of the Common
Stock hereunder, and does not purport to be complete. Purchaser further acknowledges that the Company has directed Purchaser to seek independent advice regarding the applicable provisions of the Code,
the income tax laws of any municipality, state or foreign country in which Purchaser may reside, and the tax consequences of Purchaser's death. Purchaser assumes all responsibility for filing an 83(b)
Election and paying all taxes resulting from such election or the lapse of the restrictions on the Common Stock. 

        14.    REFUSAL TO TRANSFER.    The Company shall not be required (a) to transfer on its books any shares of
Common Stock of the Company which shall have been transferred in violation of any of the provisions set forth in this Agreement or (b) to treat as owner of such shares or to accord the right to
vote as such owner or to pay dividends to any transferee to whom such shares shall have been so transferred. 

        15.    NO EMPLOYMENT RIGHTS.    This Agreement is not an employment contract and nothing in this Agreement shall
affect in any manner whatsoever the right or power of the Company (or a parent or subsidiary of the Company) to terminate Purchaser's employment for any reason at any time, with or without cause and
with or without notice. 

        16.    MISCELLANEOUS.    

         (a)    Notices.    Any notice required or permitted hereunder shall be given in writing and shall be deemed
effectively given upon personal
delivery or sent by telegram or fax or upon deposit in the United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to the other party hereto at such party's
address hereinafter shown below its signature or at such other address as such party may designate by ten (10) days' advance written notice to the other party hereto. 

        (b)    Successors and Assigns.    This Agreement shall inure to the benefit of the successors and assigns of the
Company and, subject to the
restrictions on transfer herein set forth, be binding upon Purchaser, Purchaser's successors, and assigns. The Company may assign the Repurchase Option hereunder at any time or from time to time, in
whole or in part. 

         (c)    Attorneys' Fees; Specific Performance.    Purchaser shall reimburse the Company for all costs incurred by the
Company in enforcing the
performance of, or protecting its rights under, any part of this Agreement, including reasonable costs of investigation and attorneys' fees. It is the intention of the parties that the Company, upon
exercise of the Repurchase Option and payment of the Option Price, pursuant to the terms of this Agreement, shall be entitled to receive the Common Stock, in specie, in order to have such Common Stock
available for future issuance without dilution of the holdings of other stockholders. Furthermore, it is expressly agreed between the parties that money damages are inadequate to compensate the
Company for the Common Stock and that the Company shall, upon proper exercise of the Repurchase Option, be entitled to specific enforcement of its rights to purchase and receive said Common Stock. 

5

 

        (d)    Governing Law; Venue.    This Agreement shall be governed by and construed in accordance with the laws of the
State of California. The
parties agree that any action brought by either party to interpret or enforce any provision of this Agreement shall be brought in, and each party agrees to, and does hereby, submit to the jurisdiction
and venue of, the appropriate state or federal court for the district encompassing the Company's principal place of business. 

         (e)    Further Execution.    The parties agree to take all such further action(s) as may reasonably be necessary to
carry out and consummate
this Agreement as soon as practicable, and to take whatever steps may be necessary to obtain any governmental approval in connection with or otherwise qualify the issuance of the securities that are
the subject of this Agreement. 

         (f)    Independent Counsel.    Purchaser acknowledges that this Agreement has been prepared on behalf of the Company
by Cooley Godward llp,
counsel to the Company and that Cooley Godward llp does not represent, and is not acting on behalf of, Purchaser. Purchaser has been provided with an opportunity to consult with Purchaser's own
counsel with respect to this Agreement. 

        (g)    Entire Agreement; Amendment.    This Agreement constitutes the entire agreement between the parties with respect
to the subject matter
hereof and supersedes and merges all prior agreements or understandings, whether written or oral. This Agreement may not be amended, modified or revoked, in whole or in part, except by an agreement in
writing signed by each of the parties hereto. 

         (h)    Severability.    If one or more provisions of this Agreement are held to be unenforceable under applicable law,
the parties agree to
renegotiate such provision in good faith. In the event that the parties cannot reach a mutually agreeable and enforceable replacement for such provision, then (i) such provision shall be
excluded from this Agreement, (ii) the balance of the Agreement shall be interpreted as if such provision were so excluded and (iii) the balance of the Agreement shall be enforceable in
accordance with its terms. 

         (i)    Counterparts.    This Agreement may be executed in two or more counterparts, each of which shall be deemed an
original and all of which
together shall constitute one instrument. 

                IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of                        , 2001. 

	 	 	GENOPTIX, INC.
	

 	
 	

By	

 
	 	 	 	

	

 	
 	

Title	

 
	 	 	 	

	

 	
 	

Address:	

3398 Carmel Mountain Road

San Diego, CA 92121
	

 	
 	

 Purchaser
	

Address:	
 	

	

 	
 	

ATTACHMENTS:  

	Exhibit A	 	Notice of Exercise
	Exhibit B	 	Assignment Separate from Certificate
	Exhibit C	 	Joint Escrow Instructions

6

STOCK ASSIGNMENT SEPARATE FROM CERTIFICATE  

        FOR VALUE RECEIVED,                        hereby sells, assigns and transfers unto Genoptix, Inc., a Delaware
corporation (the "Company"), pursuant to the Repurchase Option under that certain Early Exercise Stock Purchase Agreement,
dated                        by and between the undersigned and the Company (the
"Agreement"),                        
(                        ) shares of Common Stock of the Company standing in the undersigned's name on the books of the Company
represented by Certificate No(s).                        
and does hereby irrevocably constitute and appoint the Company's Secretary as attorney to transfer said Common Stock on the books of the Company with full power of substitution in the premises. This
Assignment may be used only in accordance with and subject to the terms and conditions of the Agreement, in connection with the repurchase of shares of Common Stock issued to the undersigned pursuant
to the Agreement, and only to the extent that such shares remain subject to the Company's Repurchase Option under the Agreement. 

	Dated:	 	
	 	 
	

 	
 	

 	
 	

 (Signature)
	

 	
 	

 	
 	

 (Print Name)

(INSTRUCTION:    Please do not fill in any blanks other than the "Signature" line and the "Print Name"
line.)

   JOINT ESCROW INSTRUCTIONS  

Secretary

Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121 

Dear
Sir or Madam: 

        As
Escrow Agent for both GENOPTIX, INC., a Delaware corporation ("Company"), and the undersigned purchaser of Common Stock of the
Company ("Purchaser"), you are hereby authorized and directed to hold the documents delivered to you pursuant to the terms of that certain Early Exercise Stock Purchase Agreement ("Agreement"), dated
                        to which a copy of these Joint Escrow Instructions is attached as Exhibit C, in accordance with the
following instructions: 

        1.     In the event the Company or an assignee shall elect to exercise the Repurchase Option set forth in the Agreement, the
Company or its assignee will give to Purchaser and you a written notice specifying the number of shares of Common Stock to be purchased, the purchase price, and the time for a closing hereunder at the
principal office of the Company. Purchaser and the Company hereby irrevocably authorize and direct you to close the transaction contemplated by such notice in accordance with the terms of said notice. 

        2.     At the closing you are directed (a) to date any stock assignments necessary for the transfer in question,
(b) to fill in the number of shares being transferred, and (c) to deliver same, together with the certificate evidencing the shares of Common Stock to be transferred, to the Company
against the simultaneous delivery to you of the purchase price (which may include suitable acknowledgment of cancellation of indebtedness) of the number of shares of Common Stock being purchased
pursuant to the exercise of the Repurchase Option. 

        3.     Purchaser irrevocably authorizes the Company to deposit with you any certificates evidencing shares of Common Stock to be
held by you hereunder and any additions and substitutions to said shares as specified in the Agreement. Purchaser does hereby irrevocably constitute and appoint you as the Purchaser's
attorney-in-fact and agent for the term of this escrow to execute with respect to such securities and other property all documents of assignment and/or transfer and all stock
certificates necessary or appropriate to make all securities negotiable and complete any transaction herein contemplated. 

        4.     This escrow shall terminate upon expiration or exercise in full of the Repurchase Option, whichever occurs first. 

        5.     If at the time of termination of this escrow you should have in your possession any documents, securities, or other
property belonging to Purchaser, you shall deliver all of same to Purchaser and shall be discharged of all further obligations hereunder; provided,
however, that if at the time of termination of this escrow you are advised by the Company that the property subject to this escrow is the subject of a pledge or other security
agreement, you shall deliver all such property to the pledgeholder or other person designated by the Company. 

        6.     Except as otherwise provided in these Joint Escrow Instructions, your duties hereunder may be altered, amended, modified
or revoked only by a writing signed by all of the parties hereto. 

        7.     You shall be obligated only for the performance of such duties as are specifically set forth herein and may rely and shall
be protected in relying or refraining from acting on any instrument reasonably believed by you to be genuine and to have been signed or presented by the proper party or parties or their assignees. You
shall not be personally liable for any act you may do or omit to do hereunder as Escrow Agent or as attorney-in-fact for Purchaser while acting in good faith and any act 

1

 

done
or omitted by you pursuant to the advice of your own attorneys shall be conclusive evidence of such good faith. 

        8.     You are hereby expressly authorized to disregard any and all warnings given by any of the parties hereto or by any other
person or corporation, excepting only orders or process of courts of law, and are hereby expressly authorized to comply with and obey orders, judgments or decrees of any court. In case you obey or
comply with any such order, judgment or decree of any court, you shall not be liable to any of the parties hereto or to any other person, firm or corporation by reason of such compliance,
notwithstanding any such order, judgment or decree being subsequently reversed, modified, annulled, set aside, vacated or found to have been entered without jurisdiction. 

        9.     You shall not be liable in any respect on account of the identity, authority or rights of the parties executing or
delivering or purporting to execute or deliver the Agreement or any documents or papers deposited or called for hereunder. 

        10.   You shall not be liable for the outlawing of any rights under any statute of limitations with respect to these Joint
Escrow Instructions or any documents deposited with you. 

        11.   Your responsibilities as Escrow Agent hereunder shall terminate if you shall cease to be Secretary of the Company or if
you shall resign by written notice to each party. In the event of any such termination, the Company may appoint any officer or assistant officer of the Company as successor Escrow Agent and Purchaser
hereby confirms the appointment of such successor or successors as the Purchaser's attorney-in-fact and agent to the full extent of your appointment. 

        12.   If you reasonably require other or further instruments in connection with these Joint Escrow Instructions or obligations
in respect hereto, the necessary parties hereto shall join in furnishing such instruments. 

        13.   It is understood and agreed that should any dispute arise with respect to the delivery and/or ownership or right of
possession of the securities, you are authorized and directed to retain in your possession without liability to anyone all or any part of said securities until such dispute shall have been settled
either by mutual written agreement of the parties concerned or by a final order, decree or judgment of a court of competent jurisdiction after the time for appeal has expired and no appeal has been
perfected, but you shall be under no duty whatsoever to institute or defend any such proceedings. 

        14.   Any notice required or permitted hereunder shall be given in writing and shall be deemed effectively given upon personal
delivery, including delivery by express courier or five days after deposit in the United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to each of the
other parties hereunto entitled at the following addresses, or at such other addresses as a party may designate by ten days' advance written notice to each of the other parties hereto: 

	COMPANY:	 	Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121
	
PURCHASER:	
 	

	

 	
 	

	

 	
 	

	
ESCROW AGENT:	
 	

Secretary

Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121

2

 

        15.   By signing these Joint Escrow Instructions you become a party hereto only for the purpose of said Joint Escrow
Instructions; you do not become a party to the Agreement. 

        16.   You shall be entitled to employ such legal counsel and other experts (including without limitation the firm of Cooley
Godward llp) as you may deem necessary properly to advise you in connection with your obligations hereunder. You may rely upon the advice of such counsel, and may pay such counsel reasonable
compensation therefor. The Company shall be responsible for all fees generated by such legal counsel in connection with your obligations hereunder. 

        17.   This instrument shall be binding upon and inure to the benefit of the parties hereto and their respective successors and
permitted assigns. It is understood and agreed that references to "you" or "your" herein refer to the original Escrow Agent and to any and all successor Escrow Agents. It is understood and agreed that
the Company may at any time or from time to time assign its rights under the Agreement and these Joint Escrow Instructions in whole or in part. 

        18.   This Agreement shall be governed by and interpreted and determined in accordance with the laws of the State of
California, as such laws are applied by California courts to contracts made and to be performed entirely in California by residents of that state. 

	 	 	Very truly yours,
	

 	
 	
GENOPTIX, INC.
	

 	
 	

By	

 
	 	 	 	

	

 	
 	

Title	

 
	 	 	 	

	

 	
 	
PURCHASER:
	

 	
 	

	
ESCROW AGENT:	
 	

 	

 
	

	
 	

 	

 

3

   NOTICE OF EXERCISE  

	Genoptix, Inc.

3398 Carmel Mountain Road

San Diego, CA 92121	 	

Date of Exercise:	 
	 	 	 	

Ladies
and Gentlemen: 

        This
constitutes notice under my stock option that I elect to purchase the number of shares for the price set forth below. 

	Type of option (check one):	 	 	Incentive o	 	Nonstatutory o
	

Stock option dated:	
 	
 	

 	
 	

 
	

Number of shares as to which option is exercised:	
 	
 	

 	
 	

 
	

Certificates to be issued in name of:	
 	
 	

 	
 	

 
	

Total exercise price:	
 	
$	

 	
 	

 
	

Cash payment delivered herewith:	
 	
$	

 	
 	

 
	

[Promissory note delivered herewith:	
 	
$	

 	
]	

 
	

Value of                shares of Genoptix, Inc. common stock delivered herewith(1)	
 	
$	

 	
 	

 

	(1)
	Shares
must meet the public trading requirements set forth in the option. Shares must be valued in accordance with the terms of the option being exercised, must have been owned for
the minimum period required in the option, and must be owned free and clear of any liens, claims, encumbrances or security interests. Certificates must be endorsed or accompanied by an executed
assignment separate from certificate. 

        By
this exercise, I agree (i) to provide such additional documents as you may require pursuant to the terms of the 2001 Equity Incentive Plan, (ii) to provide for the
payment by me to you (in the manner designated by you) of your withholding obligation, if any, relating to the exercise of this option, and (iii) if this exercise relates to an incentive stock
option, to notify you in writing within fifteen (15) days after the date of any disposition of any of the shares of Common Stock issued upon exercise of this option that occurs within
two (2) years after the date of grant of this option or within one (1) year after such shares of Common Stock are issued upon exercise of this option. 

        I
hereby make the following certifications and representations with respect to the number of shares of Common Stock of the Company listed above (the "Shares"), which are being acquired
by me for my own account upon exercise of the Option as set forth above: 

        I
acknowledge that the Shares have not been registered under the Securities Act of 1933, as amended (the "Securities Act"), and are deemed to constitute "restricted securities" under
Rule 701 and "control securities" under Rule 144 promulgated under the Securities Act. I warrant and represent to the Company that I have no present intention of distributing or selling
said Shares, except as permitted under the Securities Act and any applicable state securities laws. 

        I
further acknowledge that I will not be able to resell the Shares for at least ninety (90) days after the stock of the Company becomes publicly traded
(i.e., subject to the reporting requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934) under Rule 701 and that more
restrictive conditions apply to affiliates of the Company under Rule 144. 

1

 

        I
further acknowledge that all certificates representing any of the Shares subject to the provisions of the Option shall have endorsed thereon appropriate legends reflecting the
foregoing limitations, as well as any legends reflecting restrictions pursuant to the Company's Certificate of Incorporation, Bylaws and/or applicable securities laws. 

        I
further agree that, if required by the Company (or a representative of the underwriters) in connection with the first underwritten registration of the offering of any securities of the
Company under the Securities Act, I will not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same
economic effect as a sale with respect to, any Shares or other securities of the Company held by me, for a period of time specified by the underwriter(s) (not to exceed one hundred eighty
(180) days) following the effective date of the registration statement of the Company filed under the Securities Act. I further agree to execute and deliver such other agreements as may be
reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary to give further effect thereto. In order to enforce the foregoing covenant,
the Company may impose stop-transfer instructions with respect to my Shares until the end of such period. 

	

 	

Very truly yours,
	

 	

 
	

 	

2

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Exhibit 10.8    
    

 
 

AMENDED AND RESTATED SUBLEASE AGREEMENT    
    

        This Amended and Restated Sublease Agreement ("Sublease") is made as of the 1st day of May, 2006, by and between
CancerVax Corporation, a Delaware corporation ("Sublandlord"), and Genoptix, Inc., a Delaware corporation
("Subtenant") and restates in their entirety the terms and provisions of that certain Sublease, dated April 26, 2006, by and between Sublandlord
and Subtenant. 

 
 

RECITALS    
    

        This Sublease is made with regard to the following facts: 

        A.    Sublandlord
is the tenant under that certain Standard Industrial/Commercial Single-Tenant Lease-Net dated August 31, 2001 (the
"Original Lease"), with Blackmore Airport Centre, a California limited partnership (the "Master
Landlord"), as amended by that certain Amendment of Lease dated August 16, 2002 ("First Amendment"), that certain
Amendment of Lease dated May 24, 2004 ("Second Amendment") and that certain Amendment of Lease dated May 1, 2006 (the
"Third Amendment") (the Original Lease as amended by the First Amendment, the Second Amendment and the Third Amendment is referred to as the
"Master Lease") A copy of the Master Lease is attached as Exhibit A hereto. 

        B.    Section 1.2
of the Master Lease provides that the entire square footage of the building (the "Building") located at
2110 Rutherford Road, Carlsbad, California, and leased by Sublandlord is approximately 57,365 square feet of space. Sublandlord constructed additional improvements on the second floor of the Building
which resulted in an increase in the rentable square footage of the Building leased by Sublandlord to approximately 61,618 rentable square feet of space (the
"Premises"). 

        C.    Subtenant
desires to sublease from Sublandlord a portion of the Premises (the "Subleased Premises"), which Subleased
Premises are more particularly described in Exhibit B attached to this Sublease. Sublandlord has agreed to sublease the Subleased Premises to
Subtenant on the terms, covenants and conditions stated in this Sublease. 

        NOW,
THEREFORE, in consideration of the mutual covenants contained in this Sublease, and for valuable consideration, the receipt and sufficiency of which are acknowledged by the parties,
the parties agree as follows: 

        1.    Sublease.    Sublandlord subleases to Subtenant and Subtenant subleases from Sublandlord the Subleased Premises,
subject to the terms, covenants, and conditions contained in this Sublease. Sublandlord and Subtenant agree that the Subleased Premises contain 46,527 rentable square feet of space on the ground floor
of the Building. 

        2.    Term.    Subject to the condition set forth in Section 14.6 below, the terms and provisions of this
Sublease shall be effective between Sublandlord and Subtenant as of the date of mutual execution of this Sublease. The term of this Sublease (the
"Term") will commence on May 1, 2006 (the "Sublease Commencement Date") and will expire, unless
sooner terminated as provided in the Master Lease, on June 30, 2012 (the "Expiration Date"). In no event shall the Expiration Date of the
Sublease exceed the termination date of the Master Lease. 

        3.    Base Rent.    Subtenant will pay monthly base rent ("Base Rent")
for the Subleased Premises during the Term in the amount set forth in Exhibit C attached hereto. Upon execution of this Sublease, Subtenant shall
pay Base Rent for August 2006 to Sublandlord. Furthermore, in the event that the Term begins or ends on a date that is not the first day of a month, Base Rent will be prorated as of that date.
Notwithstanding anything in this Section 3, Subtenant shall not be required to pay Base Rent 

1

 

for
the months of May 2006, June 2006 and July 2006, but shall pay all other amounts required to be paid by Subtenant hereunder. 

         3.1    Security Deposit.    Subtenant shall furnish Sublandlord with an irrevocable standby letter of credit
("Letter
of Credit") in a form reasonably acceptable to Sublandlord and Comerica Bank, naming Sublandlord, as beneficiary, from Comerica Bank or other institution reasonably acceptable
to Sublandlord ("Bank") (which institution shall be acceptable to Sublandlord if Sublandlord determines it is a bank of the size and quality of Comerica
Bank), in the original amount of Four Hundred Fifty Thousand and 00/100 Dollars ($450,000.00) to be used by Sublandlord as a security deposit to secure Subtenant's faithful performance of all terms,
provisions and conditions of this Sublease. Each Letter of
Credit shall: (a) have an initial term of at least one hundred twenty (120) days; (b) be drawable upon presentation of a sight draft at the Bank's office located in San Diego,
California; (c) be transferable at Sublandlord's election to any successor of Sublandlord at Subtenant's sole cost; and (d) permit partial draws and multiple presentations. Subtenant
shall furnish the Letter of Credit to Sublandlord within five (5) business days of the full execution of this Sublease. Subtenant may replace the Letter of Credit at any time with another
letter of credit that satisfies all of the requirements for the Letter of Credit. Subtenant shall so replace each Letter of Credit at least thirty (30) days before its date of expiration (as it
may have been extended), unless such date of expiration will occur at least sixty (60) days after the Expiration Date, in which case Subtenant shall have no obligation to replace such Letter
Credit. Sublandlord may draw upon a Letter of Credit if (x) Subtenant files a voluntary petition in bankruptcy, or an involuntary petition in bankruptcy is filed against Subtenant that is not
dismissed within sixty (60) days of such filing, or (y) before the thirtieth (30th) day after the Expiration Date, the Letter of Credit is due to expire within thirty (30) days
(after taking into account any extension of the Letter of Credit that may have then occurred). Upon any default under the Sublease after expiration of the applicable cure periods, Sublandlord shall be
permitted to draw upon the Letter of Credit and use the proceeds of the Letter of Credit on the same terms and provisions of Paragraph 5 of the Master Lease; provided,
however, that Sublandlord shall only draw down such amounts that do not exceed Sublandlord's good faith estimate of the sum of (a) damages suffered by Sublandlord
because of such default and (b) the cost to cure such default. 

        If
Sublandlord draws upon the Letter of Credit, then within fifteen (15) days following Sublandlord's written request therefor, Subtenant shall replace the Letter of Credit with a
new letter of credit which meets the criteria of the Letter of Credit under this Section 3. Upon receipt of such replacement Letter of Credit from Subtenant, Sublandlord shall promptly refund
to Subtenant any amounts drawn under the former Letter of Credit that exceed amounts used to cure Subtenant's default and the amount of damages Sublandlord suffered because of such default under the
Sublease. 

        Sublandlord
and Subtenant acknowledge that the required amount of the Letter of Credit will be reduced during the Term of the Sublease, and so long as Subtenant is not then, and during
the previous twelve (12) month period, has not been, in default under this Sublease beyond applicable notice and cure periods, the required amount of the Letter of Credit (and total required
security deposit) shall be reduced as follows: 

	1.
	On
June 30, 2008, the required Letter of Credit amount shall be reduced to Three Hundred Sixty Thousand and 00/100 Dollars ($360,000.00);

	2.
	On
June 30, 2009, the required Letter of Credit amount shall be reduced to Two Hundred Seventy Thousand and 00/100 Dollars ($270,000.00);

	3.
	On
June 30, 2010, the required Letter of Credit amount shall be reduced to One Hundred Eighty Thousand and 00/100 Dollars ($180,000.00); and 

2

 

	4.
	On
June 30, 2011, the required Letter of Credit amount shall be reduced to Ninety Thousand and 00/100 Dollars ($90,000.00). 

        If
the amount of the Letter of Credit is to be reduced, then Sublandlord shall, at Subtenant's sole cost and expense, extend reasonable cooperation and execute such reasonable and
customary documents as the Bank may require in issuing any modified or replacement Letter of Credit, and shall return the Letter of Credit it then holds promptly after it receives the replacement
Letter of Credit in the reduced amount. 

        4.    Reimbursable Expenses.    Subtenant shall pay to Sublandlord, as additional rent, seventy-six
percent (76%) ("Subtenant's Pro Rata Share") of the Reimbursable Expenses (as defined below) incurred by Sublandlord during the Term of the Sublease.
Subtenant's Pro Rata Share is determined by dividing 46,527 rentable square feet of the Subleased Premises by the 61,618 rentable square feet of the Premises. Subject to Section 4.2,
"Reimbursable Expenses" means and includes all expenses incurred by Sublandlord in the operation or maintenance of the Building, including all amounts
Sublandlord is required to pay to Master Landlord under Sections 8, 10, 11 and 52 of the Master Lease, and including (i) real property taxes; (ii) real property, liability, personal
property and business interruption insurance; (iii) landscape maintenance costs; (iv) common area maintenance fees (including, but not limited to, the costs of water, gas, electricity
and telephone service to the Building, maintenance of and improvements to parking areas, loading and unloading areas, trash areas, roadways, parkways, walkways, driveways, lighting facilities, fences
and gates, trash disposal, pest control services, property management, security services and the costs of any environmental inspections); (v) all costs of maintaining and repairing the
Building; (vi) costs of maintaining, operating or repairing the Building's mechanical, electrical and other systems, including the Building's heating, ventilation and air conditioning system
("HVAC System"); (vii) costs of fire sprinkler maintenance; monitoring, testing and certification; (viii) costs of roof inspections,
repair and maintenance; (ix) concrete sealer maintenance costs; (x) fossil filter maintenance costs; (xi) backflow maintenance costs; (xii) window washing costs;
(xiii) janitorial costs; and (xiv) internal and external Building structure, maintenance and repair costs. Any costs that are specifically attributable to or incurred at the request of
or for the benefit of, a specific tenant of the Building shall be allocated entirely to such tenant and shall be excluded from Reimbursable Expenses, and Subtenant shall have no obligation to pay any
such amounts. However, Subtenant shall pay Subtenant's Pro Rata Share of any Reimbursable Expenses which are not specifically attributable to a specific tenant to Sublandlord. 

         4.1    Partial Building Occupation.    If the occupancy of the Building during any part of the Term of this Sublease
is less than
ninety-five percent (95%), Sublandlord shall make an appropriate adjustment of the variable components of the Reimbursable Expenses during that time period, as reasonably determined by
Sublandlord using sound accounting and management principles, to determine the amount of Reimbursable Expenses that would have been incurred had the Building been ninety-five percent (95%)
occupied. This amount shall be considered to have been the amount of operating expenses for such time period. For purposes of this Section 4, variable components include only those components
that are affected by variations in occupancy levels. 

         4.2    Exclusions from Reimbursable Expenses.    Despite any other provisions of this Section 4, and
notwithstanding any provision in
this Sublease to the contrary, Reimbursable Expenses shall not include the following: (i) depreciation, amortization or interest payments, and interest, principal, points and fees on debts or
amortization on any mortgage or mortgages or any other debt instrument encumbering the Building; (ii) payments of base rent under the Master Lease; (iii) legal fees incurred in
negotiating and enforcing tenant leases, and any in-house legal or accounting fees; (iv) advertising and marketing costs, including, without limitation, real estate brokers' leasing
commissions, attorneys' fees in connection with the negotiation and preparation of letters, deal memos, letters of intent, leases, subleases and/or assignments, space planning costs, 

3

 

and
other costs and expenses incurred in connection with lease, sublease and/or assignment negotiations and transactions with present or prospective tenants, subtenant or other occupants of the
Building; (v) improvements or alterations to tenant spaces or any costs incurred in renovating or otherwise improving, decorating, painting or redecorating vacant space for tenants, subtenants
or other occupants of the Building; (vi) the cost of providing any service directly to and paid directly by any tenant; (vii) any costs expressly excluded from Reimbursable Expenses
elsewhere in this Sublease; (viii) costs of capital improvements, except for costs incurred in connection with the Building that are (a) intended as a labor-saving device or to effect
other economies in the maintenance or operation of, or stability of services to, all or part of the Building, or (b) are required under any government law or regulation but that were not
required in connection with the Building when permits for the construction of the Building were obtained, and all such costs shall be amortized over the useful life of the capital improvement in
accordance with generally accepted accounting principles; (ix) any ground lease rental; (x) costs incurred by Sublandlord for the repair of damage to the Building, to the extent that
Sublandlord is reimbursed by insurance proceeds; (xi) expenses in connection with services or other benefits which are not offered to or provided to Subtenant and which are offered or provided
to another tenant or occupant of the Building; (xii) costs incurred by Sublandlord due to the negligent or intentional violation by Sublandlord of the Master Lease unless caused by Subtenant;
(xiii) costs incurred in connection with upgrading the Building (but not the Premises) to comply with disability, life, fire and safety codes, ordinances, statutes, or other laws in effect
prior to the Commencement Date, including, without limitation, the Americans with Disabilities Act, including penalties or damages incurred due to such non-compliance; (xiv) tax
penalties incurred as a result of Sublandlord's negligence, inability or unwillingness to make payments and/or to file any tax or informational returns when due; (xv) any management fees in
excess of those management fees which are normally and customarily charged by landlords of buildings which are located in the vicinity of and are comparable to the Building
("Comparable Buildings"); (xvi) costs arising from the negligence or fault of other tenants or Sublandlord or its agents, or any vendors,
contractors, or providers of materials or services selected, hired or engaged by Sublandlord or its agents; and (xvii) notwithstanding any contrary provision of the Sublease, including, without
limitation, any provision relating to capital expenditures, any and all costs arising from the presence on the date hereof of hazardous materials or substances (as defined by applicable laws in effect
on the date the Sublease is executed) in or about the Subleased Premises or the Building, including, without limitation, Hazardous Substances in the ground water or soil, not placed on the Premises or
in the Building by Subtenant; and (xviii) costs arising from latent defects in the base, shell or core of the Building of which Sublandlord is aware on the date hereof. 

         4.3    Payment of Reimbursable Expenses.    Subtenant shall pay to Sublandlord: (a) Subtenant's Pro Rata Share of
Reimbursable Expenses
at least three (3) business days prior to the date Sublandlord must pay Sublandlord's share to the Master Landlord pursuant to the terms of the Master Lease if the Master Lease requires
Sublandlord to pay such amount to the Master Landlord, provided that Sublandlord shall have delivered a statement of estimated or actual Subtenant's Pro Rata Share to Subtenant; and (b) within
ten (10) days after the Sublandlord presents a reasonably detailed statement of actual expenses to Subtenant for all other Reimbursable Expenses. At Subtenant's reasonable request, Sublandlord
shall provide Subtenant with additional documentation relating to the actual Reimbursable Expenses set out in such statement. At Sublandlord's option, however, an amount may be estimated by
Sublandlord from time to time of Subtenant's actual share of Reimbursable Expenses and the same shall be payable monthly or quarterly as Sublandlord shall designate, during each twelve month period of
the Term, on the same day as Base Rent is due hereunder. Sublandlord shall deliver to Subtenant within sixty (60) days after the expiration of each calendar year a reasonably detailed statement
showing Subtenant's actual share of Reimbursable Expenses incurred during such calendar year 

4

 

("Reconciliation Statement"). If Subtenant's payments under this Section 4 during the preceding year exceed Subtenant's actual share of the
Reimbursable Expenses incurred during such year as indicated on the Reconciliation Statement, Sublandlord shall credit the amount of such overpayment against Subtenant's Pro Rata Share of the
Reimbursable Expenses next becoming due. If Subtenant's payments under this Section 4 during the preceding year were less than Subtenant's share as indicated on the Reconciliation Statement,
Subtenant shall pay to Sublandlord the amount of the deficiency within ten (10) days after delivery by Sublandlord to Subtenant of the Reconciliation Statement. Notwithstanding any provision to
the contrary in this Sublease, in the event that Sublandlord fails to deliver the Reconciliation Statement within three hundred sixty-five (365) days after the expiration of the
applicable calendar year, including the calendar year in which the Expiration Date or date of earlier termination of this Sublease falls, Sublandlord shall be conclusively deemed to have waived its
right to recover any amount of deficiency for such calendar year, and in no event shall Subtenant have any obligation to pay such amount. 

        4.4    Audit Right.    In the event of any dispute as to any amount due hereunder by Subtenant for Reimbursable
Expenses, Subtenant shall have
the right upon reasonable advance written notice to inspect Sublandlord's accounting records relative to Reimbursable Expenses at the office in the building in which Sublandlord maintains its records
during normal business hours at any time within ninety (90) days following the furnishing by Sublandlord to Subtenant of such statement, provided that such records shall be maintained in the
continental United States. Any outside consultant engaged by Subtenant in connection with such review shall be engaged only on a non-contingency fee basis and shall be a certified public
accountant. If Subtenant objects to Sublandlord's calculation by written notice delivered to Sublandlord within such ninety (90) day period, then a certification as to the proper amount of
Reimbursable Expenses shall be made by another independent Certified Public Accountant mutually agreed upon by the parties, which certification shall be final and conclusive. Subtenant agrees to pay
the cost of such certification unless it is determined that Sublandlord's original determination of Reimbursable Expenses was in error by more than five percent (5%) over Subtenant's actual
obligation, in which case Sublandlord shall pay the cost of such certification and all of Subtenant's audit costs. 

        5.    Right of First Refusal.    Subtenant shall have, during the Sublease Term and any extensions thereof, the
continuing right of first refusal (the "Right of First Refusal"), subject to consent by the Master Landlord, to lease the entire second floor of the
Building or portion thereof but only for office-related use (the "Second Floor Space") which Second Floor Space consists of approximately 15,091
rentable square feet. At such time as Sublandlord receives a bona fide offer from a third party to lease all or any portion of the Second Floor Space which Sublandlord is willing to accept,
Sublandlord shall provide Subtenant with written notice thereof (the "Notice"). The Notice shall specify all of the basic economic terms of
Sublandlord's proposed leasing of the Second Floor Space or portion hereof, including the term, rental rate, any tenant improvement allowance, free rent periods, any other material financial terms and
the portion of the Second Floor Space to be subleased. Upon receipt of the Notice, Subtenant's Right of First Refusal will be triggered and the following provisions shall control Subtenant's exercise
(or non-exercise) thereof. 

         5.1    Procedure.    Subtenant shall have five (5) business days from receipt of the Notice during which to
exercise Subtenant's Right
of First Refusal to lease the Second Floor Space (or portion thereof). Such election may only be made by Subtenant's delivery of written notice ("Exercise
Notice") to Sublandlord within such five (5) business day period. Subtenant's failure to timely provide the Exercise Notice to the Sublandlord shall constitute
Subtenant's deemed waiver of Subtenant's Right of First Refusal, and Sublandlord may thereafter sublease the Second Floor Space to any prospective tenant, subject to obtaining consent of the Master
Landlord, on all of the same terms as those set forth in the Notice. If no such sublease is executed with a subtenant within sixty (60) days after the expiration of the five (5) business
day period following receipt of 

5

 

the
Notice on the same terms as provided in the Notice, then Subtenant's Right of First Refusal will be reinstated on the terms and provisions of this Section 5, including reinstatement of
Subtenant's rights to receive an updated Notice. In the event that Sublandlord timely enters into a sublease with a third party for less than the entirety of the Second Floor Space, Subtenant's Right
of First Refusal shall apply to the balance of the Second Floor Space. 

         5.2    Exercise.    Upon exercise by the Subtenant of Subtenant's Right of First Refusal pursuant to delivery of the
Exercise Notice,
(i) Sublandlord shall use its good faith efforts and commercially reasonable diligence to obtain the consent of the Master Landlord within thirty (30) days of delivery of the Exercise
Notice, (ii) upon obtaining the consent of the Master Landlord, Subtenant and Sublandlord shall, within fifteen (15) days after obtaining the Master Landlord's consent, execute an
amendment to this Sublease to include the Second Floor Space as part of the Subleased Premises, (iii) the rental rate, rent increases, rent commencement, tenant improvement allowance (if any),
and other economic terms and conditions applicable to such additional space (other than the term) shall be those set forth in the applicable Notice delivered to Subtenant pursuant to this
Section 5, and (iv) all of the other terms and conditions of this Sublease shall apply to the Second Floor Space, as if originally included as part of the Subleased Premises. If the
Sublandlord is unable to obtain the consent of the Master Landlord to the Subtenant's exercise of the Right of First Refusal within forty-five (45) days of Subtenant's exercise of
the Right of First Refusal, then Subtenant's exercise of the Right of First Refusal shall be deemed null and void, and the Sublandlord may thereafter sublease the Second Floor Space to any prospective
subtenant on the same terms and conditions on which the Sublandlord could have offered the Second Floor Space if Subtenant had not exercised Subtenant's Right of First Refusal. 

        6.    Use.    Subtenant agrees to use the Subleased Premises in accordance with the provisions of the Master Lease and
this Sublease, and for no other purpose. 

        7.    Master Lease.    As applied to this Sublease, the words "Lessor" and "Lessee" in the Master Lease will be deemed
to refer to Sublandlord and Subtenant, respectively, under this Sublease. 

        Except
as otherwise expressly provided in Section 9 of this Sublease, the covenants, agreements, provisions, and conditions of the Master Lease, to the extent that they relate to
the Subleased Premises and to the extent that they are not inconsistent with the terms of this Sublease, are made a part of and incorporated into this Sublease as if recited in full in this Sublease. 

        Except
as otherwise provided herein, the rights and obligations of the Master Landlord, as "Lessor," and the Subtenant, as "Lessee," under the Master Lease will be deemed the rights and
obligations of Sublandlord and Subtenant, respectively, under this Sublease, and will inure to the benefit of, and be binding on, Sublandlord and Subtenant, respectively. As between the parties to
this Sublease only, in the event of a conflict between the terms of the Master Lease and the terms of this Sublease, the terms of this Sublease will control. For the avoidance of doubt, this means
that if Subtenant must obtain the Master Landlord's consent under the Master Lease for any matter, then under this Sublease, the Subtenant must obtain the consent of both Sublandlord and Master
Landlord. 

        8.    Performance by Sublandlord; Status of Master Lease.    

         8.1    Sublandlord's Performance Conditioned on Master Landlord's Performance. Subtenant recognizes that Sublandlord is not in a position
to render any
of the services or to perform any of the obligations required of Master Landlord by the terms of the Master Lease, except as otherwise provided in this Sublease. Therefore, despite anything to the
contrary in this Sublease, Subtenant agrees that performance by Sublandlord of its obligations under this Sublease is conditioned on performance by the Master Landlord of its corresponding obligations
under the Master Lease, and Sublandlord will not be liable to Subtenant for any default of the Master Landlord under the 

6

 

Master
Lease, except to the extent caused by Sublandlord's default under the Master Lease which is not caused by Subtenant's default hereunder. 

        Subtenant
will not have any claim against Sublandlord based on the Master Landlord's failure or refusal to comply with any of the provisions of the Master Lease unless that failure or
refusal is a result of Sublandlord's breach of the Master Lease. Despite the Master Landlord's failure or refusal to comply with any of those provisions of the Master Lease, this Sublease will remain
in full force and effect and Subtenant will pay the base rent and additional rent and all other charges provided for in this Sublease without any abatement, deduction or setoff. Except as expressly
provided in this Sublease, Subtenant agrees to be subject to, and bound by, all of the covenants, agreements, terms, provisions, and conditions of the Master Lease, as though Subtenant was Lessee
under the Master Lease. 

        8.2    Obtaining Master Landlord's Consent.    Whenever the consent of the Master Landlord is required under the Master
Lease, and whenever
the Master Landlord fails to perform its obligations under the Master Lease, Sublandlord agrees to use its good faith efforts to obtain, at Subtenant's sole cost and expense, that consent or
performance on behalf of Subtenant. Sublandlord covenants and agrees with Subtenant that Sublandlord will pay all fixed rent and additional rent payable by Sublandlord as Lessee pursuant to the Master
Lease. 

        8.3    No Existing Defaults. Sublandlord represents and warrants to Subtenant that the Master Lease is in full force and effect, and
Sublandlord has
neither given nor received a notice of default under the Master Lease, and to Sublandlord's knowledge, no event has occurred or condition exists, which, with the passage of time or giving of notice,
would constitute a default under the Master Lease. 

         8.4    Preservation of Master Lease.    Sublandlord agrees not to terminate the Master Lease voluntarily, or modify
the Master Lease in a
manner that increases Subtenant's obligations or adversely affects Subtenant's rights under this Sublease without Subtenant's prior written consent; provided,
however, Sublandlord shall give prior written notice to Subtenant of any proposed modifications to the Master Lease, and shall provide Subtenant with copies of any
modifications to the Master Lease promptly following execution by Sublandlord and Master Landlord. In the event of any Sublandlord Termination Event (as defined below), Sublandlord shall be liable
for, and Subtenant shall be entitled to recover, Subtenant's actual damages incurred due to the termination of this Sublease as a result of such Sublandlord Termination Event, including costs incurred
in securing alternative comparable space. "Sublandlord Termination Event" means a termination of the Master Lease where Subtenant is not permitted or
offered the opportunity to remain in the Subleased Premises on the same terms as this Sublease, and which termination is the result of: (i) a default of Sublandlord under the Master Lease, and
such Sublandlord default was not as a result of a Subtenant default under this Sublease; (ii) the result of any election or exercise of a right or option held by Sublandlord under the Master
Lease to effect such termination; or (iii) Sublandlord's mutual agreement with the Master Landlord to terminate the Master Lease outside the parameters of the Master Lease. Subtenant and
Sublandlord will each refrain from any act or omission that would result in the failure or breach of any of the covenants, provisions, or conditions of the Master Lease on the part of Lessee under the
Master Lease, provided that Subtenant's compliance with its obligations under this Sublease shall satisfy the foregoing requirement. Subtenant shall not have any claim against Master Landlord due to
Sublandlord's default under the Master Lease. If Sublandlord is in monetary default under the Master Lease, then Sublandlord hereby grants Subtenant the right to advance funds directly to Master
Landlord to cure a monetary default under the Master Lease so that Subtenant can remain in the Subleased Premises and Subtenant shall be entitled to recover such advanced funds from Sublandlord. 

7

 

        9.    Variations from Master Lease.    As between Sublandlord and Subtenant, only the terms and conditions of the
Master Lease are modified as stated below in this Section 9: 

         9.1    Base Rent; Term; Security Deposit.    Despite anything to the contrary stated in the Master Lease, the Term of
this Sublease and Base
Rent and the amount of the security deposit required of the Subtenant are as stated in Sections 2 and 3 above. 

        9.2    Brokers.    The parties to this Sublease warrant to each other that neither party dealt with any broker or
finder in connection with
the consummation of this Sublease other than Burnham Real Estate and Irving Hughes (the "Brokers"), and each party agrees to protect, defend, indemnify
and hold the other party harmless from and against any and all claims or liabilities for brokerage commissions or finder's fees arising out of that party's acts in connection with this Sublease to
anyone other than the Brokers. Sublandlord shall be solely responsible for payment of all fees and commissions to the Brokers payable in connection with this Sublease. The provisions of this
Section 9.2 will survive the expiration or earlier termination of this Sublease. 

        9.3    Maintenance of the Building.    Subject to Section 14.7 and 14.8, Sublandlord, subject to reimbursement
pursuant to
Section 4, shall keep in good order, condition and repair the foundations, exterior walls, interior bearing walls, exterior roof, fire sprinkler system, fire hydrants, parking lots, walkways,
parkways, driveways, landscaping, fences, signs and utility systems that serve the common areas or that serve both the Second Floor Space and the Premises and shall maintain and operate the HVAC
System. Sublandlord shall not be obligated to paint the exterior or interior surfaces of exterior walls nor shall Sublandlord be obligated to maintain, repair or replace windows, doors or plate glass
of the Premises. Subtenant expressly waives the benefit of any statute now or hereafter in effect to the extent it is inconsistent with the terms of this Sublease. 

         9.4    Notices.    Any notice that may or must be given by either party under this Sublease will be delivered
(i) personally,
(ii) by certified mail, return receipt requested, or (iii) by a nationally recognized overnight courier, addressed to the party to whom it is intended. Any notice given to Sublandlord or
Subtenant shall be sent to the respective address set forth on the signature page below, or to such other address as that party may designate for service of notice by a notice given in accordance with
the provisions of this Section 9.4. A notice sent pursuant to the terms of this Section 9.4 shall be deemed delivered (A) when delivery is attempted, if delivered personally,
(B) three (3) business days after deposit into the United States mail, or (C) the business day following deposit with a nationally recognized overnight courier. 

         9.5    Amounts Payable.    All amounts payable under this Sublease by Subtenant are payable directly to Sublandlord.

8

  

        9.6    Provisions of Master Lease Not Applicable.    The following
provisions of the Master Lease shall not apply to this Sublease: (a) Sections 1.1 through 1.7, inclusive, 1.10, 3, 10.1, 10.2, 15, 16.1 (provided that Subtenant shall execute any such statement
if so requested by Master Landlord), 22 (but only the last sentence thereof), 23, 50, 51, 54, 62 and 63, (b) Exhibits A, B, and C to the Master Lease, (c) the entire Second Amendment,
and (d) all references in the Master Lease to "Tenant Improvements" and "Letter of Credit." 

        9.7    "As-Is."    Sublandlord will deliver the Subleased
Premises to Subtenant in their current "as is" condition; provided, however, that the Subleased Premises shall be in broom-clean condition, and the
Sublandlord shall deliver all plumbing, mechanical, electrical lighting and other building systems in the Subleased Premises to the Subtenant in good working order. 

        Notwithstanding
the foregoing, Sublandlord, at Sublandlord's sole cost, shall use commercially reasonable efforts to, prior to the Commencement Date, (a) install additional key
card security readers in the Building for purposes of protecting the Subleased Premises against unauthorized access by the occupant of the Building's second floor (the "Second
Floor Occupant"), and to protect the second floor of the Building against unauthorized access, as set forth in greater detail in  Exhibit D-1, and (b) construct a
demising wall as set forth in greater detail in  Exhibit D-2. The Subtenant shall control, manage, operate and maintain the key card security access system of the Building. At the
direction of any Second Floor Occupant, the Subtenant shall issue key cards to such individuals designated by any Second Floor Occupant and shall manage the key card security access system so that
only such designated individuals are permitted access to the Second Floor Space and so that such designated individuals are not permitted access to the Subleased Premises. 

        9.8    Furniture, Fixtures and Equipment.    Sublandlord and Subtenant
agree that the Subleased Premises contain the furniture, fixtures and equipment listed on Exhibit E to this Sublease (the
"FF&E"). The FF&E shall not contain any furniture, fixtures or equipment currently located in the Second Floor Space. Subject to the last sentence of
this Section 9.8, Subtenant will not remove, and shall have no obligation to remove, any of the FF&E on the expiration of the Term of this Sublease. Subtenant shall have free use of all
existing FF&E during the Term, excluding any readily moveable scientific equipment (the "Moveable Equipment") which has been sold prior to May 1,
2006. Sublandlord shall not be permitted to remove any of the FF&E other than the Moveable Equipment from the Subleased Premises. Subtenant shall be entitled to an option to purchase the FF&E (other
than any Moveable Equipment sold by Sublandlord prior to May 1, 2006 as permitted hereunder) for the sum of $1.00 immediately following the thirty-sixth (36th) month of this
Sublease, which option may be exercised by written notice by Subtenant given to Sublandlord at any time thereafter during the Term. Following Subtenant's exercise of its option hereunder, the parties
shall execute all agreements, instruments and undertakings reasonably necessary to transfer Sublandlord's right, title and interest in, to and under such FF&E to Subtenant. Notwithstanding the
foregoing, at the expiration or earlier termination of the
Sublease, Subtenant shall return the Subleased Premises to the same condition they were in when Sublandlord delivered the Premises to Subtenant as set forth in Section 9.7 above. 

        9.9    Parking.    Subject to the terms of the Master Lease, Subtenant
shall have exclusive use of 159 unreserved parking spaces (Subtenant's Pro Rata Share of the 210 available parking spaces) on the Premises as designated by the Sublandlord from time to time. Subtenant
shall not service or store any vehicles on the Premises. 

        9.10    Common Areas.    The term "Common Areas" is defined as all
areas and facilities outside the Building and within the exterior boundary line of the Premises and interior utility raceways and installations within the Building that are provided and designated by
Sublandlord from time to time for the general non-exclusive use of Sublandlord, Subtenant and other tenants of the Building and their respective employees, suppliers, shippers, customers,
contractors and 

9

 

invitees,
including stairwells, elevator, parking areas, loading and unloading areas, trash areas, roadways, driveways, walkways, and landscaped areas. The Sublandlord grants the Subtenant, for the
benefit of Subtenant, its employees, suppliers, shippers, contractors, customer and invitees, during the Term of this Sublease, the nonexclusive right to use, in common with others entitled to such
use, the Common Areas as they exist from time to time, subject to any rights, powers and privileges reserved by Sublandlord or the Master Landlord under the terms of this Sublease or the Master Lease. 

        9.11    Reception.    Subtenant shall permit the Second Floor Occupant
and its officers, employees, contractors and invitees (collectively, "Second Floor Occupant Parties") to have access to the Second Floor Space
twenty-four (24) hours per day, seven (7) days per week through the Building's lobby and reception area portion of the Subleased Premises that is shown as shaded on  Exhibit F as attached
hereto (the "Reception Area"), and Sublandlord reserves such right herein;
provided, however, the Second Floor Occupant Parties shall comply with all reasonable security requirements and policies of Subtenant that do not
unreasonably restrict access to the Second Floor Space in connection with such access rights. 

        9.12    Signage.    Subject to Section 34 of the Master Lease,
Subtenant shall be allowed external monument signage as is approved by the Sublandlord and Master Landlord. The size of such external signage and directional signage shall be consistent with
Subtenant's Pro Rata Share. Subtenant shall also be allowed exclusive internal signage in the Reception Area of the Building as is approved by the Sublandlord and Master Landlord and the Second Floor
Occupant's internal signage rights shall be limited to the second floor of the Building; provided, however, the Second Floor Occupant shall be permitted
internal directional signage in the Reception Area consistent with its pro rata share of rentable square footage in the Building, which signage shall be subject to Subtenant's prior approval. 

        9.13    Improvements.    Subject to Section 7.3 of the
Sublease, Subtenant shall not make any improvements or alterations to the Subleased Premises without the prior written consent of Sublandlord and Master Landlord. Although consent shall be required
from the Master Landlord, no prior consent of Sublandlord shall be required for any alterations which are non-structural in nature, do not adversely affect the Building systems and do not
exceed $25,000.00 in any year. Subtenant shall present to Sublandlord in written form detailed plans for any proposed improvements or alterations. All consents given by Sublandlord shall be deemed
conditioned upon (i) the consent of the Master Landlord (including any conditions required by the Master Landlord), (ii) Subtenant's acquiring all applicable permits required by
governmental authorities, (iii) the furnishing of copies of such permits together with a copy of the plans and specifications for such improvements or alterations to Sublandlord prior to the
commencement of the work thereon, and (iv) the compliance by Subtenant with all conditions of said permits. Subtenant shall remove any alterations installed by Subtenant as directed by Master
Landlord (through Sublandlord) at the expiration or earlier termination of this Sublease. Any improvements or alterations done by Subtenant during the Term of this Sublease shall be done in a good and
workmanlike manner with good and sufficient materials and in compliance with all applicable laws. The Subtenant shall promptly upon the completion thereof furnish Sublandlord with as-built
plans and specifications therefor. Sublandlord may (but without obligation to do so) condition its consent to any requested improvement or alteration that costs $100,000.00 or more upon Subtenant's
providing Sublandlord with a lien and completion bond in an amount equal to one and one-half times the estimated cost of such improvement or alteration and/or upon Subtenant's posting an
additional security deposit with Sublandlord under Section 3 hereof. 

        10.    Indemnity.    Subtenant agrees to protect, defend, indemnify,
and hold Sublandlord harmless from and against any and all liabilities, claims, expenses, losses and damages (including reasonable attorney fees and costs), that may at any time be asserted against
Sublandlord by (a) the Master 

10

 

Landlord
for failure of Subtenant to perform any of the covenants, agreements, terms, provisions, or conditions contained in the Master Lease that Subtenant is obligated to perform under the
provisions of this Sublease; or (b) any person as a result of Subtenant's use or occupancy of the Subleased Premises, except to the extent any of the foregoing is caused by the gross negligence
or willful misconduct of Sublandlord. The provisions of this Section 10 will survive the expiration or earlier termination of this Sublease. 

        11.    Cancellation of Master Lease.    In the event the Master Lease
is canceled or terminated for any reason, or involuntarily surrendered by operation of law before the expiration date of this Sublease, Subtenant agrees, at the sole option of the Master Landlord,
either to attorn to the Master Landlord for the balance of the Term of this Sublease and on the then executory terms of this Sublease or immediately vacate the Premises. That attornment will be
evidenced by a non-disturbance agreement in form and substance reasonably satisfactory to the Master Landlord and Subtenant. Subtenant agrees to execute and deliver such an agreement at
any time within ten (10) business days after request by the Master Landlord. Subtenant waives the provisions of any law now or later in effect that may provide Subtenant any right to terminate
this Sublease or to surrender possession of the Subleased Premises in the event any proceeding is brought by the Master Landlord to terminate the Master Lease. Notwithstanding the foregoing,
Sublandlord shall allow Subtenant, upon Subtenant's monetary default under the Master Lease, to cure such monetary default under the Master Lease as described in Section 8.4 of this Sublease.
This Subtenant right to cure is designed to allow
Subtenant to remain in the Subleased Premises in the event of that Sublandlord experiences financial difficulties. 

        12.    Certificates.    Each party to this Sublease will, from time to
time as requested by the other party, on not less than twenty (20) days prior written notice, execute, acknowledge, and deliver to the other party a statement in writing certifying that this
Sublease is unmodified and in full force and effect (or if there have been modifications that this Sublease is in full force and effect as modified and stating the modifications). That statement will
certify the dates to which base rent, additional rent, and any other charges have been paid. That statement will also state whether, to the knowledge of the person signing the certificate, the other
party is in default beyond any applicable grace period provided in this Sublease in the performance of any of its obligations under this Sublease. If the other party is in default beyond any
applicable grace period, the statement will specify each default of which the signer then has knowledge. It is intended that this statement may be relied on by others with whom the party requesting
that certificate may be dealing. 

        13.    Assignment or Subleasing.    Subtenant may not assign this
Sublease or sublet all or any portion of the Subleased Premises; provided, however, Subtenant may assign this Sublease to any affiliate of Subtenant
with the prior written consent of the Sublandlord and the Master Landlord. 

        14.    General Provisions.    

        14.1    Severability.    If any provision of this Sublease or the
application of any provision of this Sublease to any person or circumstance is, to any extent, held to be invalid or unenforceable, the remainder of this Sublease or the application of that provision
to persons or circumstances other than those as to which it is held invalid or unenforceable, will not be affected, and each provision of this Sublease will be valid and be enforced to the fullest
extent permitted by law. 

        14.2    Entire Agreement; Waiver.    This Sublease constitutes the
final, complete and exclusive statement between the parties to this Sublease pertaining to the Subleased Premises, supersedes all prior and contemporaneous understandings or agreements of the parties,
and is binding on and inures to the benefit of their respective heirs, representatives, successors, and assigns. No party has been induced to enter into this Sublease by, nor is any party relying on,
any representation or warranty outside those expressly set forth in this Sublease. Any agreement made after the date of this Sublease is ineffective to modify, waive, release, terminate, or effect an
abandonment of this 

11

 

Sublease,
in whole or in part, unless that agreement is in writing, is signed by the parties to this Sublease, and specifically states that that agreement modifies this Sublease. 

        14.3    Captions.    Captions to the Sections in this Sublease are
included for convenience only and do not modify any of the terms of this Sublease. 

        14.4    Further Assurances.    Each party to this Sublease will at its
own cost and expense execute and deliver such further documents and instruments and will take such other actions as may be reasonably required or appropriate to evidence or carry out the intent and
purposes of this Sublease. 

        14.5    Governing Law.    This Sublease will be governed by and in all
respects construed in accordance with the laws of the State of California. 

        14.6    Consent of Landlord.    The Master Landlord's written consent
to this Sublease in accordance with the terms of Article 12 of the Master Lease is a condition subsequent to the validity of this Sublease. If the Master Landlord's consent has not been
obtained and a copy of that consent delivered to Subtenant by the thirtieth (30th) day following the date of this Sublease, each party shall thereafter have the ongoing right, subject to the terms of
this Section 14.6, to terminate this Sublease pursuant to a notice (the "Termination Notice") so stating delivered to Sublandlord. If Sublandlord
fails to deliver to Subtenant the consent of Master Landlord to this Sublease within ten (10) days following receipt of the Termination Notice (the "Termination
Date"), this Sublease shall automatically terminate and the parties shall be released from any further obligations under this Sublease. If, however, Sublandlord delivers to
Subtenant the consent of Master Landlord on or before the Termination Date, the condition subsequent set forth in this Section 14.6 shall be satisfied and this Sublease shall continue in full
force and effect. 

        14.7    Condemnation.    In the event that all of the Subleased
Premises are taken, this Sublease shall terminate in accordance with the terms of the Master Lease. If less than all of the entire Subleased Premises are taken, the provisions of the Master Lease
shall control with respect to whether this Sublease will be terminated as a result thereof, and with respect to restoration of the Subleased Premises. Subtenant shall have no right to share in any
condemnation proceeds received by Sublandlord; provided, however, Subtenant shall have the right to pursue any separate award for loss of its equipment,
trade fixtures and moving expenses. In no event will Sublandlord be in default under this Sublease or be liable to Subtenant or any other person for direct, indirect, or consequential damages, or
otherwise (except to the extent caused by Sublandlord's gross negligence or willful misconduct), for any termination of the Master Lease pursuant to such provisions, or for any failure of Master
Landlord to repair or restore the Subleased Premises or to otherwise perform any of its obligations under such condemnation provisions in the Master Lease. 

        14.8    Casualty.    In the event that the Subleased Premises shall be
damaged by fire or other casualty, Sublandlord shall have no responsibility for restoration of the Subleased Premises. The casualty provisions of the Master Lease shall control with respect to
termination of this Sublease and restoration of the Subleased Premises. In no event will Sublandlord be in default under this Sublease or be liable to Subtenant or any other person for direct,
indirect or consequential damages, or otherwise (except to the extent caused by Sublandlord's gross negligence or willful misconduct), for any termination of the Master Lease pursuant to such
provisions, or for any failure of Master Landlord to
repair or restore the Subleased Premises or to otherwise perform any of its obligations under such casualty provisions in the Master Lease. 

        14.9    Capitalized Terms.    All terms spelled with initial capital
letters in this Sublease that are not expressly defined in this Sublease will have the respective meanings given such terms in the Master Lease. 

12

 

        14.10    Word Usage.    Unless the context clearly requires otherwise,
(a) the plural and singular numbers will each be deemed to include the other; (b) the masculine, feminine, and neuter genders will each be deemed to include the others;
(c) "shall," "will," "must," "agrees," and "covenants" are each mandatory; (d) "may" is permissive; (e) "or" is not exclusive; and (f) "includes" and "including" are not
limiting. 

        14.11    "Including".    The term "including" as used herein shall be
interpreted to mean including without limitation. 

        14.12    Incorporation of Exhibits.    The various exhibits to this
Sublease are hereby incorporated by reference into this Sublease. 

        14.13    Venue; Counterparts.    In any action brought or arising out
of this Sublease, the parties hereto hereby consent to the jurisdiction of any federal or state court having proper venue within the State of California and also consent to the service of process by
any means authorized by California or federal law. The parties hereby agree that any proceeding relating to any dispute under this Sublease or with respect to the interpretation of any provision of
this Sublease shall be conducted in San Diego, California. This Sublease may be executed in one or more counterparts, all of which, taken together, shall constitute one and the same Sublease. 

13

 

        The
parties have executed this Sublease as of the date specified above. 

	 	 	SUBLANDLORD:
	 	 	 	 	 
	 	 	CANCERVAX CORPORATION,

a Delaware corporation
	 	 	 	 	 
	 	 	 	 	 
	 	 	By:	 	/s/  WILLIAM R. LARUE      

	

 	
 	

Name:	
 	

William R. LaRue

	

 	
 	

Title:	
 	

SVP—CFO

	 	 	 	 	 
	 	 	 	 	 
	 	 	SUBTENANT:
	 	 	 	 	 
	 	 	GENOPTIX, INC.

a Delaware corporation
	 	 	 	 	 
	 	 	 	 	 
	 	 	By:	 	/s/  TINA S. NOVA      

	

 	
 	

Name:	
 	

Tina S. Nova, Ph.D.

	

 	
 	

Title:	
 	

President & CEO

14

  

 
 

[GRAPHIC]    AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION    
    

 
 

STANDARD INDUSTRIAL/COMMERCIAL SINGLE-TENANT LEASE—NET
  (Do not use this form for Multi-Tenant Property)    
    

1.     Basic Provisions ("Basic Provisions")  

        1.1    Parties:    This Lease ("Lease"), dated for reference purposes
only, August 31, 2001, is made by and between BLACKMORE AIRPORT CENTRE, A CALIFORNIA LIMITED PARTNERSHIP ("Lessor") and CANCERVAX CORPORATION  ("Lessee"), (collectively the "Parties," or individually a  "Party"). 

        1.2    Premises:    That certain real property, including all improvements therein or to be provided by Lessor under
the terms of this Lease, and commonly known by the street address of 2110 Rutherford Road, Carlsbad located in the County of San Diego, State of California and generally described as (describe briefly
the nature of the property) an approximately 57,365 square foot freestanding, single-tenant, concrete tilt-up building to be built in shell condition situated on 3.693 acres of land with
210 onsite parking spaces ("Premises"). (See Paragraph 2 for further provisions.) 

        1.3    Term:    Ten (10) years and -0- months ("Original
Term") commencing July 1, 2002 ("Commencement Date") and ending June 30, 2012 ("Expiration
Date"). (See Paragraph 3 for further provisions.) 

        1.4    Early Possession:    Upon Substaintial Completion of the Tenant Improvement  [Illegible]
 ("Early Possession Date"). (See Paragraphs 3.2 and 3.3 for further provisions.) provided Lessor is in receipt
of first months rent and security deposit. 

        1.5    Base Rent:    $112,000.00 per month ("Base Rent"), payable on
the first day of each month commencing July 1, 2002 (See Paragraph 4 for further provisions.) 

	ý
	If
this box is checked, there are provisions in this Lease for the Base Rent to be adjusted. 

        1.6    Base Rent Due May 1, 2002:    $112,000.00 as Base Rent for the period July 1-31,
2002. 

        1.7    Security Deposit:    $    see Paragraph 51    ("Security
Deposit"), (See Paragraph 5 for further provisions.) 

        1.8    Permitted Use:    Corporate headquarters, R&D lab space and pilot manufacturing plant for a biotech company
and
other legal, related uses. (See Paragraph 6 for further provisions.) 

        1.9    Insuring Party:    Lessor is the "Insuring Party" unless
otherwise stated herein. (See Paragraph 8 for further provisions.) 

        1.10    Real Estate Brokers:    The following real estate brokers (collectively, the  "Brokers")
 and brokerage relationships exist in this transaction and are consented to by the Parties (check applicable boxes): 

	Blackmore & Associates, Inc.	 	represents
	
	 	 

	ý
	Lessor
exclusively ("Lessor's Broker");
o    both Lessor and Lessee, and 

	Burnham Real Estate Services	 	represents
	
	 	 

	ý
	Lessee
exclusively ("Lessee's Broker");
o    both Lessee and Lessor. (See Paragraph 15 for further provisions.) 

        1.11    Guarantor.    The obligations of the Lessee under this Lease are to be guaranteed
by     N/A    ("Guarantor"). (See Paragraph 37 for further provisions.) 

1

 

        1.12    Addenda.    Attached hereto is an Addendum or Addenda consisting of Paragraphs 49 through 64 and
Exhibits A-G all of which constitute a part of this Lease. 

2.     Premises.  

        2.1    Letting.    Lessor hereby leases to Lessee, and Lessee hereby leases from Lessor, the Premises, for the term,
at the rental, and upon all of the terms, covenants and conditions set forth in this Lease. Unless otherwise provided herein, any statement of square footage set forth in this Lease, or that may have
been used in calculating rental, is an approximation which Lessor and Lessee agree is reasonable and the rental based thereon is not subject to revision whether or not the actual square footage is
more or less. 

        2.2    Condition.    Lessor shall deliver the Premises to Lessee clean and free of debris and Hazardous Substance
Conditions on the Commencement Data and warrants to Lessee that the existing plumbing, fire sprinkler system, lighting, air conditioning, heating, and loading doors, if any, in the Premises, other
than those constructed by Lessee, shall be in good operating condition on the Commencement Date. If a non-compliance with said warranty exists as of the Commencement Date, Lessor shall,
except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee setting forth with specificity the nature and extent of such non-compliance, rectify same
at Lessor's expense. If Lessee does not give Lessor written notice of a non-compliance with this warranty within One (1) year after the Commencement Date, correction of that
non-compliance shall be the obligation of Lessee at Lessee's sole cost and expense. 

        2.3    Compliance with Covenants, Restrictions and Building Code.    Lessor warrants to Lessee that the improvements
on the Premises comply with all applicable covenants or restrictions of record and applicable building codes, regulations and ordinances in effect on the Commencement Date. Said warranty does not
apply to the use to which Lessee will put the Premises or to any Alterations or Utility installations (as defined in Paragraph 7.3(a)) made or to be made by Lessee. If the Premises do not
comply with said warranty, Lessor shall, except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee setting forth with specificity the nature and extent of such
non-compliance, rectify the same at Lessor's expense. If Lessee does not give Lessor written notice of a non-compliance with this warranty within six (6) months
following the Commencement Date, correction of that non-compliance shall be the obligation of Lessee at Lessee's sole cost and expense. 

        2.4    Acceptance of Premises.    Lessee hereby acknowledges: (a) that it has been advised by the Brokers to
satisfy itself with respect to the present and future suitability of the Premises for Lessee's intended use, (b) that Lessee has made such investigation as it deems necessary with reference to
such matters and assumes all responsibility therefor as the same relate to Lessee's occupancy of the Premises and/or the term of this Lease, and (c) that neither Leasor, nor any of Lessor's
agents, has made any oral or written representations or warranties with respect to the said matters other than as set forth in this Lease. 

        2.5    Lessee Prior Owner/Occupant.    The warranties made by Lessor in this Paragraph 2 shall be of no force
or effect if immediately prior to the date set forth in Paragraph 1.1 Lessee was the owner or occupant of the Premises. In such event, Lessee shall, at Lessee's sole cost and expense, correct
any non-compliance of the Premises with said warranties. 

3.     Term.  

        3.1    Term.    The Commencement Date, Expiration Date and Original Term of this Lease are as specified in
Paragraph 1.3. 

        3.2    Early Possession.    If Lessee totally or partially occupies the Premises prior to the Commencement Date, the
obligation to pay Base Rent shall be abated for the period of such early 

2

 

possession.
All other terms of this Lease, however, (including but not limited to the obligations to pay Real Property Taxes and Insurance premiums and to maintain the Premises) shall be in effect
during such period. Any such early possession shall not affect nor advance the Expiration Date of the Original Term. 

        3.3    Delay in Possession.    If for any reason Lessor cannot deliver possession of the Premises to Lessee as agreed
herein by the Early Possession Date, if one is specified in Paragraph 1.4, or, if no Early Possession Date is specified, by the Commencement Date, Lessor shall not be subject to any liability
therefor, nor shall such failure affect the validity of this Lease, or the obligations of Lessee hereunder, or extent the term hereof, but in such case, Lessee shall be obligated to pay rent and
perform any other obligation of Lessee under the terms of this Lease until Lessor delivers possession of the Premises to Lessee. (See Paragraph 49a.) 

4.     Rent.  

        4.1    Base Rent.    Subject to the terms and conditions of Paragraph 50 Lessee shall cause payment of Base
Rent and other rent or charges, as the same may be adjusted from time to time, to be received by Lessor in lawful money of the United States, without offset or deduction, on or before the day on which
it is due under the terms of this Lease. Base Rent and all other rent and charges for any period during the term hereof which is for less than one (1) full calendar month shall be prorated
based upon the actual number of days of the calendar month involved. Payment of Base Rent and other charges shall be made to Lessor at its address stated herein or to such other persons or at such
other addresses as Lessor may from time to time designate in writing to Lessee. 

        5.    Security Deposit.    Subject to the terms and conditions of Paragraph 51 Lessee shall deposit with Lessor
upon execution hereof the Security Deposit in the form of a Letter of Credit set forth in Paragraph 51, as security for Lessee's faithful performance of Lessee's obligations under this Lease.
If Lessee fails to
pay Base Rent or other rent or charges due hereunder, or otherwise Defaults under this Lease (as defined in Paragraph 13.1), Lessor may use, apply or retain all or any portion of said Security
Deposit for the payment of any amount due Lessor or to reimburse or compensate Lessor for any liability, cost, expense, loss or damage (including attorneys' fees) which Lessor may suffer or incur by
reason thereof. If Lessor uses or applies all or any portion of said Security Deposit, Lessee shall within ten (10) days after written request therefor deposit moneys with Lessor sufficient to
restore said Security Deposit to the full amount required by this Lease. Lessor shall not be required to keep all or any part of the Security Deposit separate from its general accounts. Lessor shall,
at the expiration or earlier termination of the term hereof and after Lessee has vacated the Premises, return to Lessee (or, at Lessor's option, to the last assignee, if any, of Lessee's interest
herein), that portion of the Security Deposit not used or applied by Lessor. Unless otherwise expressly agreed in writing by Lessor, no part of the Security Deposit shall be considered to be held in
trust, to bear interest or other increment for its use, or to be prepayment for any moneys to be paid by Lessee under this Lease. 

6.     Use.  

        6.1    Use.    Lessee shall use and occupy the Premises only for the purpose set forth in Paragraph 1.8, or any
other use which is comparable thereto, and for no other purpose. Lessee shall not use or permit the use of the Premises in a manner that creates waste or a nuisance, or that disturbs owners and/or
occupants of, or causes damage to, neighboring premises or properties. 

        6.2    Hazardous Substances.    

        (a)    Reportable Uses Require Consent.    The term "Hazardous
Substance" as used in this Lease shall mean any product, substance, chemical, material or waste whose presence, nature, quantity and/or intensity of existence, use, manufacture, disposal,
transportation, spill, release or effect, either by itself or in combination with other materials expected to be on the Premises, is 

3

 

either:
(i) potentially injurious to the public health, safety or welfare, the environment or the Premises, (ii) regulated or monitored by any governmental authority, or (iii) a
basis for liability of Lessor to any governmental agency or third party under any applicable statute or common law theory. Hazardous Substance shall include, but not be limited to, hydrocarbons,
petroleum, gasoline, crude oil or any products, by-products or fractions thereof. Lessee shall not engage in any activity in, on or about the Premises which constitutes a Reportable Use
(as hereinafter defined) of Hazardous Substances and shall comply in a timely manner (at Lessee's sole cost and expense) with all Applicable Law (as defined in Paragraph 6.3).  "Reportable Use"
shall mean (i) the installation or use of any above or below ground storage tank, (ii) the generation, possession,
storage, use, transportation, or disposal of a Hazardous Substance that requires a permit from, or with respect to which a report, notice, registration or business plan is required to be filed with,
any governmental authority. Reportable Use shall also include Lessee's being responsible for the presence in, on or about the Premises of a Hazardous Substance with respect to which any Applicable Law
requires that a notice be given to persons entering or occupying the Premises or neighboring properties. Notwithstanding the foregoing, Lessee may, without Lessor's prior consent, but in compliance
with all Applicable Law, use any ordinary and customary materials reasonably required to be used by Lessee in the normal course of Lessee's business permitted on the Premises, so long as such use is
not a Reportable Use and does not expose the Premises or neighboring properties to any meaningful risk of contamination or damage or expose Lessor to any liability therefor, in addition, Lessor may
(but without any obligation to do so) condition its consent to the use or presence of any Hazardous Substance, activity or storage tank by Lessee upon Lessee's giving Lessor such additional assurances
as Lessor, in its reasonable discretion, deems necessary to protect itself, the public, the Premises and the environment against damage, contamination or injury and/or liability therefrom or therefor,
including, but not limited to, the installation (and removal on or before Lease expiration or earlier termination) of reasonably necessary protective modifications to the Premises (such as concrete
encasements) and/or the deposit of an additional Security Deposit under Paragraph 5 hereof. 

        (b)    Duty to inform Lessor.    If Lessee knows, or has reasonable
cause to believe, that a Hazardous Substance, or a condition involving or resulting from same, has come to be located in, on, under or about the Premises, other than as previously consented to by
Lessor, Lessee shall immediately give written notice of such fact to Lessor. Lessee shall also immediately give Lessor a copy of any statement, report, notice, registration, application, permit,
business plan, license, claim, action or proceeding given to, or received from, any governmental authority or private party, or persons entering or occupying the premises, concerning the presence,
split, release, discharge of, or exposure to, any Hazardous Substance or contamination in, on, about the Premises, including but not limited to all such documents as may be involved in any Reportable
Uses involving the Premises or in violation of applicable laws. 

        (c)    Indemnification.    Lessee shall indemnify, protect, defend and
hold Lessor, its agents, employees, lenders and ground lessor, if any, and the Premises, harmless from and against any and all loss of rents and/or damages, liabilities, judgments, costs, claims,
liens, expenses, penalties, permits and attorney's
and consultant's fees arising out of or involving any Hazardous Substance or storage tank brought onto the Premises by or for Lessee or under Lessee's control. Lessee's obligations under this
Paragraph 6 shall include, but not be limited to, the effects of any contamination or injury to person, property or the environment created or suffered by Lessee, and the cost of investigation
(including consultant's and attorney's fees and testing), removal, remediation, restoration and/or abatement thereof, or of any contamination therein involved, and shall survive the expiration or
earlier termination of this Lease. No termination, cancellation or release agreement entered into by Lessor and Lessee shall release Lessee from its obligations under this Lease with respect to
Hazardous Substances or storage tanks, unless specifically so agreed by Lessor in writing at the time of such agreement. (See Paragraph 49b.) 

4

           6.3    Lessee's Compliance with Law.    Except as otherwise provided in this Lease,
Lessee, shall, at Lessee's sole
cost and expense, fully, diligently and in a timely manner, comply with all "Applicable Law," which term is used in this Lease to include all laws,
rules, regulations, ordinances, directives, convenants, easements and restrictions of record, permits, the requirements of any applicable fire insurance underwriter or rating bureau, and the
recommendations of Lessor's engineers and/or consultant, relating in any manner to the Premises (including but not limited to matters pertaining to (i) industrial hygiene,
(ii) environmental conditions on, in, under or about the premises, including soil and groundwater conditions, and (iii) the use, generation, manufacture, production, installation,
maintenance, removal, transportation, storage, spill or release of any Hazardous Substance or storage tank, now in effect or which may hereafter come into effect, and whether or not reflecting a
change in policy from any previously existing policy. Lessee shall, within five (5) days after receipt of Lessor's written request, provide Lessor with copies of all documents and information,
including, but not limited to, permits registrations, manifests, applications, reports and certificates, evidencing Lessee's compliance with any Applicable Law reasonably specified by Lessor, and
shall immediately upon receipt, notify Lessor in writing (with copies of any documents involved) of any threatened or actual claim, notice, citation, warning, complaint or report pertaining to or
involving failure by Lessee or the Premises to comply with any Applicable Law. 

        6.4    Inspection; Compliance.    Lessor and Lessor's Lender(s) (as defined in Paragraph 8.3(a)) shall have the
right to enter the Premises at any time, in the case of an emergency, and otherwise at reasonable times upon at least twenty-four (24) hours prior notice for the purpose of
inspecting the condition of the Premises and for verifying compliance by Lessee with this Lease and all Applicable Laws (as defined in Paragraph 6.3), and to employ experts and/or consultants
in connection therewith and/or to advise Lessor with respect to Lessee's activities, including but not limited to the installation, operation, use, monitoring, maintenance, or removal of any Hazardous
Substance or storage tank on or from the Premises. The costs and expenses of any such inspections shall be paid by the party requesting same, unless a Default or Breach of this Lease, violation of
Applicable Law or a contamination caused or materially contributed to by Lessee is found to exist or be imminent, or unless the inspection is requested or ordered by a governmental authority as the
result of any such existing or imminent violation or contamination. In any such case, Lessee shall upon request reimburse Lessor or Lessor's Lender, as the case may be, for the costs and expenses of
such inspections and a certified copy of such report shall be provided to Lessee. 

7.     Maintenance; Repairs; Utility Installation; Trade Fixtures and Alternations.  

        7.1    Lessee's Obligations.    

        (a)   Subject
to the provisions of Paragraphs 2.2 (Lessor's warranty as to condition), 2.3 (Lessor's warranty as to compliance with covenants, etc), 7.2 (Lessor's
obligations to repair), 9 (damage and destruction), and 14 (condemnation), Lessee shall, at Lessee's sole cost and expense and at all times, keep the Premises and every part thereof in good order,
condition and repair, structural and non-structural (whether or not such portion of the Premises requiring repair, or the means of repairing the same, are reasonably or readily accessible
to Lessee, and whether or not the need for such repairs occurs as a results of Lesser's use, any prior use, the elements or the age of such portion of the Premises), including, without limiting the
generality of the foregoing, all equipment or facilities serving the Premises, such as plumbing, heating, air conditioning, ventilating, electrical, lighting facilities, boilers, fired or unfired
pressure vessels, for sprinkler and/or standpipe and hose or other automatic fire extinguishing system, including fire alarm and/or smoke detection systems and equipment, fire hydrants, fixtures,
walls (interior and exterior), foundations, ceilings, roots, floors, windows, doors, plate glass, skylights, landscaping, driveways, parking lots, fences, retaining walls, signs, sidewalls and
parkways located in on about, or adjacent to the Premises. Lesses shall not cause or permit any Hazardous Substance to be spilled or 

6

 

released
in, on, under or about the Premises (including through the plumbing or sanitary sewer system) and shall promptly, at Lessees's expense, take all investigatory and/or remedial action
reasonably recommended, whether or not formally ordered or required, for the cleanup of any contamination of, and for the maintenance, security and/or monitoring of the Premises, the elements
surrounding same, or neighboring properties, that was caused or materially contributed to by Lessee, or pertaining to or involving any Hazardous Substance and/or storage tank brought onto the Premises
by or for Lessee or under its control. Lessee, in keeping the Premises in good order, condition and repair shall exercise and perform good maintenance practices. Lessee's obligations shall include
restorations, replacements or renewals when necessary to keep the Premises and all improvements thereon or a part thereof in good order, condition and state of repair. If Lessee occupies the Premises
for seven (7) years or more, Lessor may require Lessee to repaint the exterior of the buildings on the Premises as reasonably required, but not more frequently than once every seven (7)
years. 

        7.2    Lessor's Obligations.    Except for the warranties and agreements of Lessor contained in Paragraph 2.2
(relating to condition of the Premises), 2.3 (relating to compliance with convenants, restrictions and building code), 9 (relating to destruction of the Premises) and 14, (relating to condemnation of
the Premises), and Lessor's obligation to repair and maintain the structural portion of the building exterior walls, roof structure and foundations), it is intended by the Parties hereto that Lessor
have no obligation, in any manner whatsoever, to repair and maintain the Premises, the improvements located thereon, or the equipment therein, whether structural or non structural, all of which
obligations are intended to be that of the Lessee under Paragraph 7.1 hereof. It is the intention of the Parties that the terms of this Lease govern the respective obligations of the Parties as
to maintenance and repair of the Premises. Lessee and Lessor expressly waive the benefit of any statute now or hereafter in effect to the extent it is inconsistent with the terms of the Lease with
respect to, or which affords Lessee the right to make repairs at the expense of Lessor or to terminate this Lease by reason of, any needed repairs. (See Paragraph 49c.) 

7.3   Utility Installations; Trade Fixtures; Alterations.  

        (a)    Definitions; Consent Required.    The term  "Utility Installations"
is used in this Lease to refer to all carpeting, window coverings, air lines, power panels, electrical distribution, security,
fire protection systems, communication systems, lighting fixtures, heating, ventilating and air conditioning equipment, plumbing, and fencing in, on or about the Premises. The term  "Trade Fixtures"
shall mean Lessee's machinery and equipment that can be removed without doing material damage to the Premises. The term "Alterations"
shall mean any modification of the improvements on the Premises from that which are provided by Lessor under the terms of this Lease, other than Utility Installations or Trade Fixtures, whether by
addition or deletion. "Lessee Owned Alteration and/or Utility Installations" are defined as Alterations and/or Utility Installations made by Lessee that
are not yet owned by Lessor as defined in Paragraph 7.4 (a). Lessee shall not make any Alterations or Utility Installations in, on, under or about the Premises without Lessor's prior written
consent which shall not be unreasonably withheld, conditioned or delayed Lessee may, however, notifying Lessor in advance in writing make non-structural Utility Installations to the
interior of the Premises (excluding the roof), as long as they are not visible from the outside, do not involve puncturing, relocating or removing the roof or any existing walls, and the cumulative
cost thereof during the term of this Lease as extended does not exceed $100,000. (See Paragraph 49d.) 

        (b)    Consent.    Any Alterations or Utility Installations that
Lessee shall desire to make and which require the consent of the Lessor shall be presented to Lessor in written form with proposed detailed plans. All consents given by Lessor, whether by virtue of
Paragraph 7.3(a) or by subsequent specific consent, shall be deemed conditioned upon: (i) Lessee's acquiring all 

7

 

applicable
permits required by governmental authorities, (ii) the furnishing of copies of such permits together with a copy of the plans and specifications for the Alteration or Utility
Installation to Lessor prior to commencement of the work thereon, and (iii) the compliance by Lessee with all conditions of said permission in a prompt and expeditious manner. Any Alterations
or Utility Installations by Lessee during the term of this Lease shall be done in a good and workmanlike manner with good and sufficient materials, and in compliance with all Applicable Law. Lessee
shall promptly upon completion thereof furnish Lessor with as-built plans and specifications therefor. Lessor may (but without obligation to do so) condition its consent to any requested Alteration or
Utility Installation that costs $100,000 or more upon Lessee's providing Lessor with a lien and completion bond in an amount equal to one and one-half the estimated cost of such Alteration
or Utility Installation and/or upon Lessor's posting an additional Security Deposit with Lessor under Paragraph 36 hereof. 

        (c)    Indemnification.    Lessee shall pay, when due, all claims for
labor or materials furnished or alleged to have been furnished to or for Lessee at or for use on the Premises, which claims are or may be secured by any mechanics' or materialmen's lien against the
Premises or any interest therein. Lessee shall give
Lessor not less than ten (10) days' notice prior to the commencement of any work in, on or about the Premises, and Lessor shall have the right to post notices of non-responsibility
in or on the Premises as provided by law. If Lessee shall, in good faith, contest the validity of any such lien, claim or demand, then Lessee shall, at its sole expense defend and protect itself,
Lessor and the Premises against the same and shall pay and satisfy any such adverse judgment that may be rendered thereon before the enforcement thereof against the Lessor or the Premises. If Lessor
shall require, Lessee shall furnish to Lessor a surety bond satisfactory to Lessor in an amount equal to one and one-half times the amount of such contested lien, claim or demand,
indemnifying Lessor against liability for the same, as required by law for the holding of the Premises free from the effect of such lien or claim. In addition, Lessor may require Lessee to pay
Lessor's reasonable attorney's fees and costs in participating in such action if Lessor shall decide it is to its best interest to do so. 

7.4   Ownership; Removal; Surrender; and Restoration.  

        (a)    Ownership.    Subject to Lessor's right to require their
removal or become the owner thereof as hereinafter provided in this Paragraph 7.4, all Alterations and Utility Additions made to the Premises by Lessee shall be the property of and owned by
Lessee, but considered a part of the Premises. Lessor may, at any time and at its option, elect in writing to Lessee to be the owner of all or any specified part of the Lessee Owned Alterations, and
Utility Installations. Unless otherwise instructed per subparagraph 7.4(b) hereof, all Lessee Owned Alterations and Utility Installations shall, at the expiration or earlier termination of this
Lease, become the property of Lessor and remain upon and be surrendered by Lessee with the Premises. 

        (b)    Removal.    Unless otherwise agreed in writing, Lessor may (at
the time Lessor gives its consent to the installation) require that any or all Lessee Owned Alterations or Utility Installations be removed by the expiration or earlier termination of this Lease,
notwithstanding their installation may have been consented to by Lessor. Lessor may require the removal at any time of all or any part of any Lessee Owned Alterations or Utility Installations made
without the required consent of Lessor. 

        (c)    Surrender/Restoration.    Lessee shall surrender the Premises
by the end of the last day of the Lease term or any earlier termination date, with all of the improvements, parts and surfaces thereof clean and free of debris and in good operating order, condition
and state of repair, ordinary wear and tear excepted and subject to Paragraph 9 hereof. "Ordinary wear and tear" shall not include any damage or
deterioration that would have been prevented by good maintenance practice or by Lessee performing all of its obligations under this Lease. Except as 

8

 

otherwise
agreed or specified in writing by Lessor, the Premises, as surrendered, shall include the Utility Installations. The obligation of Lessee shall include the repair of any damage occasioned by
the installation, maintenance or removal of Lessee's Trade Fixtures, furnishings, equipment, and Alterations and/or Utility Installations, as well as the removal of any storage tank installed by or
for Lessee, and the removal, replacement, or remediation of any soil, material or ground water contaminated by Lessee, all as may then be required by Applicable Law and/or good practice. Lessee's
Trade Fixtures shall remain the property of Lessee and shall be removed by Lessee subject to its obligation to repair and restore the Premises per this Lease. (See Paragraph 49(e).) 

8.     Insurance; Indemnity.  

        8.1    Payment For Insurance.    Regardless of whether the Lessor or Lessee is the insuring Party, Lessee shall pay
for all insurance required under this Paragraph 8 except to the extent of the cost attributable to liability insurance carried by Lessor in excess of $1,000,000 per occurrence. Premiums for
policy periods commencing prior to or extending beyond the Lease term shall be prorated to correspond to the Lease term. Payment shall be made by Lessee to Lessor within ten (10) days following
receipt of an invoice for any amount due. 

        8.2    Liability Insurance.    

        (a)    Carried by Lessee.    Lessee shall obtain and keep in force
during the term of this Lease a Commercial General Liability policy of insurance protecting Lessee and Lessor (as an additional insured) against claims for bodily injury, personal injury and property
damage based upon, involving or arising out of the ownership, use, occupancy or maintenance of the Premises and all areas appurtenant thereto. Such insurance shall be on an occurrence basis providing
single limit coverage in an amount not less than $1,000,000 per occurrence with an "Additional Insured-Managers or Lessors of Premises" Endorsement and contain the "Amendment of the Pollution
Exclusion" for damage caused by heat, smoke or fumes from a hostile fire. The policy shall not contain any intra-insured exclusions as between insured persons or organizations, but shall include
coverage for liability assumed under this Lease as an "insured contract" for the performance of Lessee's indemnity obligations under this Lease. The limits of said insurance required by this Lease or
as carried by Lessee shall not, however, limit the liability of Lessee
nor relieve Lessee of any obligation hereunder. All insurance to be carried by Lessee shall be primary to and not contributory with any similar insurance carried by Lessor, whose insurance shall be
considered excess insurance only. 

        (b)    Carried By Lessor.    In the event Lessor is the Insuring
Party, Lessor shall also maintain liability insurance described in Paragraph 8.2(a), above, in addition to, and not in lieu of, the insurance required to be maintained by Lessee. Lessee shall
not be named as an additional insured therein. 

        8.3    Property Insurance—Building, Improvements and Rental Value.    

        (a)    Building and Improvements.    The Insuring Party shall obtain
and keep in force during the term of this Lease a policy or policies in the name of Lessor, with loss payable to Lessor and to the holders of any mortgages, deeds of trust or ground leases on the
Premises ("Lender(s)"), insuring loss or damage to the Premises. The amount of such insurance shall be equal to the full replacement cost of the Premises, as the same shall exist from time to time, or
the amount required by Lenders, but in no event more than the commercially reasonable and available insurable value thereof if, by reason of the unique nature or age of the improvements involved, such
latter amount is less than full replacement cost. If Lessor is the Insuring Party, however, Lessee Owned Alterations and Utility Installations shall be insured by Lessee under Paragraph 8.4
rather than by Lessor. If the coverage is available and commercially appropriate, such policy or policies shall insure against all risks of direct physical loss or damage (except the perils of flood
and/or earthquake unless required by a Lender), including coverage for any additional costs 

9

 

resulting
from debris removal and reasonable amounts of coverage for the enforcement of any ordinance or law regulating the reconstruction or replacement of any undamaged sections of the Premises
required to be demolished or removed by reason of the enforcement of any building, zoning, safety or land uses laws as the result of a covered cause of loss. Said policy or policies shall also contain
an agreed valuation provision in lieu of any coinsurance clause, waiver of subrogation, and inflation guard protection causing an increase in the annual property insurance coverage amount by a factor
of not less than the adjusted U.S. Department of Labor Consumer Price Index for All Urban Consumers for the city nearest to where the Premises are located. If such insurance coverage has a deductible
clause, the deductible amount shall not exceed $1,000 per occurrence, and Lessee shall be liable for such deductible amount in the event of an Insured Loss, as defined in Paragraph 9.1(c). 

        (b)    Rental Value.    The Insuring Party shall, in addition, obtain
and keep in force during the term of this Lease a policy or policies in the name of Lessor, with loss payable to Lessor and Lender(s), insuring the loss of the full rental and other charges payable by
Lessee to Lessor under this Lease for one (1) year (including all real estate taxes, insurance costs, and any scheduled rental increases). Said Insurance shall provide that in the event the
Lease is terminated by reason of an insured loss, the period of indemnity for such coverage shall be extended beyond the date of the completion of repairs or replacement of the Premises, to provide
for one full year's loss of rental revenues from the date of any such loss. Said insurance shall contain an agreed valuation provision in lieu of any coinsurance
clause, and the amount of coverage shall be adjusted annually to reflect the projected rental income, property taxes, insurance premium costs and other expenses, if any, otherwise payable by Lessee
for the next twelve (12) month period. Lessee shall be liable for any deductible amount in the event of such loss. 

        (d)    Tenant's Improvement's.    If the Lessor is the Insuring Party,
the Lessor shall not be required to insure Lessee Owned Alterations and Utility Installations unless the item in question has become the property of Lessor under the terms of this Lease. If Lessee is
the Insuring Party, the policy carried by Lessee under this Paragraph 8.3 shall insure Lessee Owned Alterations and Utility Installations. 

        8.4    Lessee's Property Insurance.    Subject to the requirements of Paragraph 8.5, Lessee at its cost shall
either by separate policy or, at Lessor's option, by endorsement to a policy already carried, maintain insurance coverage on all of Lessee's personal property, Lessee Owned Alterations and Utility
Installations in, on, or about the Premises similar in coverage to that carried by the Insuring Party under Paragraph 8.3. Such Insurance shall be full replacement cost coverage with a
deductible of not to exceed $50,000 per occurrence. The proceeds from any such insurance shall be used by Lessee for the replacement of personal property or the restoration of Lessee Owned Alterations
and Utility Installations. Lessee shall be the Insuring Party with respect to the insurance required by this Paragraph 8.4 and shall provide Lessor with written evidence that such insurance is
in force. 

        8.5    Insurance Policies.    Insurance required hereunder shall be in companies duly licensed to transact business in
the state where the Premises are located, and maintaining during the policy term a "General Policyholders Rating" of at least B+, V, or such other rating as may be required by a Lender having a lien
on the Premises, as set forth in the most current issue of "Best's Insurance Guide." Lessee shall not do or permit to be done anything which shall invalidate the insurance policies referred to in this
Paragraph 8. If Lessee is the Insuring Party, Lessee shall cause to be delivered to Lessor certified copies of policies of such insurance or certificates evidencing the existence and amounts of
such insurance with the insureds and loss payable clauses as required by this Lease. No such policy shall be cancellable or subject to modification except after thirty (30) days prior written notice
to Lessor. Lessee shall at least thirty (30) days prior to the expiration of such policies, furnish Lessor with evidence of renewals or "insurance binders" evidencing renewal thereof, or Lessor may
order such insurance and charge the cost thereof to Lessee, which amount shall be payable by Lessee to Lessor 

10

 

upon
demand. If the Insuring Party shall fail to procure and maintain the insurance required to be carried by the Insuring Party under this Paragraph 8, the other Party may, but shall not be
required to, procure and maintain the same, but at Lessee's expense. 

        8.6    Waiver of Subrogation.    Without affecting any other rights or remedies Lessee and Lessor  ("Waiving Party") each hereby release and relieve the other, and waive their entire right to recover damages (whether in contract or in tort) against
the other, for loss of or damage to the Waiving Party's property arising out of or incident to the perils required to be insured against under Paragraph 8. The effect of
such releases and waivers of the right to recover damages shall not be limited by the amount of insurance carried or required, or by any deductibles applicable thereto. 

        8.7    Indemnity.    Except for Lessor's negligence and/or breach of express warranties, Lessee shall indemnify,
protect, defend and hold harmless the Premises, Lessor and its agents, Lessor's master or ground lessor, partners and Lenders, from and against any and all claims, loss of rents and/or damages, costs,
liens, judgments, penalties, permits, attorney's and consultant's fees, expenses and/or liabilities arising out of, involving, or in dealing with, the occupancy of the Premises by Lessee, the conduct
of Lessee's business, any act, omission of neglect of Lessee, its agents, contractors, employees or invitees, and out of any Default or Breach by Lessee in the performance in a timely manner of any
obligation on Lessee's part to be performed under this Lease. The foregoing shall include, but not be limited to, the defense or pursuit of any claim or any action or proceeding involved therein, and
whether or not (in the case of claims made against Lessor) litigated and/or reduced to judgment, and whether well founded or not. In case any action or proceeding be brought against Lessor by reason
of any of the foregoing matters, Lessee upon notice from Lessor shall defend the same at Lessee's expense by counsel reasonably satisfactory to Lessor and Lessor shall cooperate with Lessee in such
defense. Lessor need not have first paid any such claim in order to be so indemnified. (See Paragraph 49f.) 

        8.8    Exemption of Lessor from Liability.    Lessor shall not be liable for injury or damage to the person or goods,
wares, merchandise or other property of Lessee, Lessee's employees, contractors, invitees, customers, or any other person in or about the Premises, whether such damage or injury is caused by or result
from fire, steam, electricity, gas, water or rain, or from the breakage, leakage, obstruction or other defects of pipes, fire sprinklers, wires, appliances, plumbing, air conditioning or lighting
fixtures, or from any other cause, whether the said injury or damage results from conditions arising upon the Premises or upon other portions of the building of which the Premises are a part, or from
other sources or places, and regardless of whether the cause of such damage or injury or the means of repairing the same is accessible or not. Lessor shall not be liable for any damages arising from
any act or neglect of any other tenant of Lessor. Notwithstanding Lessor's negligence or breach of this Lease, Lessor shall under no circumstances be liable for injury to Lessee's business or for any
loss of income or profit therefrom. 

9.     Damage or Destruction.  

        9.1    Definitions.    

        (a)   "Premises Partial Damage" shall mean damage or destruction to the improvements on the Premises, other than Lessee Owned
Alterations and Utility Installations, the repair cost of which damage or destruction is less than 50% of the then Replacement Cost of the Premises immediately prior to such damage or destruction,
excluding from such calculation the value of the land and Lessee Owned Alterations and Utility Installations. 

        (b)   "Premises Total Destruction" shall mean damage or destruction to the Premises, other than Lessee Owned Alterations and
Utility Installations the repair cost of which damage or destruction is 50% or more of the then Replacement Cost of the Premises immediately prior to such damage or destruction, excluding from such
calculation the value of the land and Lessee Owned Alterations and Utility Installations. 

11

  

        (c)   "Insured Loss" shall mean damage or destruction to improvements on the Premises, other than Lessee Owned Alterations and
Utility Installations, which was caused by an event required to be covered by the Insurance described in Paragraph 8.3(a), irrespective of any deductible amounts or coverage limits involved. 

        (d)   "Replacement Cost" shall mean the cost to repair or rebuild the improvements owned by Lessor at the time of the
occurrence to their conditions existing immediately prior thereto, including demotion, debris removal and upgrading required by the operation of applicable building codes, ordinances or laws, and
without deduction for depreciation. 

        (e)   "Hazardous Substance Condition" shall mean the occurrence or discovery of a condition involving the presence of or a
contamination by, a Hazardous Substances as defined in Paragraph 5.2(a), in, on, or under the Premises. 

        9.2    Partial Damage—Insured Loss.    If a Premises Partial Damage that is an Insured Loss occurs, then
Lessor shall, at Lessor's expense, repair such damage (but not Lessee's Trade Fixtures or Lessee Owned Alterations and Utility Installations) as soon as reasonably possible and this Lease shall
continue in full force and effect; provided, however, that Lessee shall, at Lessor's election, make the repair of any damage or destruction the total cost to repair of which is $10,000 or less, and in
such event, Lessor shall make the insurance proceeds available to Lessee on a reasonable basis for that purpose. Notwithstanding the foregoing, if the required insurance was not in force or the
insurance proceeds are not sufficient to effect such repair, the insuring Party shall promptly contribute the shortage in proceeds (except as to the deductible which is Lessee's responsibility) as and
when required to complete said repairs, in the event, however, the shortage in proceeds was due to the fact that, by reason of the unique nature of the improvements, full replacement costs insurance
coverage was not commercially reasonable and available. Lessor shall have no obligation to pay for the shortage in insurance proceeds or to fully restore the unique aspects of the Premises unless
Lessee provides Lessor with the funds to cover same, or adequate assurance thereof, within thirty 30 days following receipt of written notice of such shortage and request therefor. If Lessor
receives said funds or adequate assurance thereof within said thirty 30 day period, the party responsible for making the repairs shall complete them as soon as reasonably possible and this
Lease shall remain in full force and effect. If Lessor does not receive such funds or assurance within said period, Lessor may nevertheless elect by written notice to Lessee within ten
(10) days thereafter to make such restoration and repair as is commercially reasonable with Lessor paying any shortage in proceeds. In which case this Lease shall remain in full force and
effect. If in such case Lessor does not so elect, then this Lease shall terminate sixty (60) days following the occurrence of the damage or destruction, Unless otherwise agreed, Lessee shall in
no event have any right to reimbursement from Lessor for any funds contributed by Leasee to repair any such damage or destruction. Premises Partial Damage due to food or earthquake shall be subject to
Paragraph 9.3 rather than Paragraph 9.2, notwithstanding that there may be some insurance
coverage, but the net proceeds of any such insurance shall be made available for the repairs if made by either Party. (See Paragraph 49g.) 

        9.3    Partial Damage—Uninsured Loss.    If a Premises Partial Damage that is not an insured Loss occurs,
unless caused by a negligent or willful act of Lessee (in which event Lessee shall make the repairs at Lessee's expense and this Lease shall continue in full force and effect, but subject to Lessor's
rights under Paragraph 13), Lessor may at Lessor's option, either: (i) repair such damage as soon as reasonably possible at Lessor's expense, in which event this Lease shall continue in
full force and effect, or (ii) give written notice to Lessee within thirty (30) days after receipt by Lessor of knowledge of the occurrence of such damage of Lessor's desire to terminate this
Lease as of the date sixty (60) days following the giving of such notice. In the event Lessor elects to give such notice of Lessor's intention to terminate this Lease. Lessee shall have the right
within ten (10) days after the receipt of such notice to give written notice to Lessor of Lessee's commitment to pay for the repair of such damage totally at Lessee's expense and without reimbursement
from Lessor. Lessee shall provide 

12

 

Lessor
with the required funds or satisfactory assurance thereof within thirty (30) days following Lessee's said commitment. In such event this Lease shall continue in full force and effect, and
Lessor shall proceed to make such repairs as soon as reasonably possible and the required funds are available, if Lessee does not give such notice and provide the funds or assurance thereof within the
times specified above, this Lease shall terminate as of the date specified in Lessor's notice of termination. 

        9.4    Total Destruction.    Notwithstanding any other provision hereof, if a Premises Total Destruction occurs
(including any destruction required by any authorized public authority), this Lease shall terminate sixty (60) days following the date of such Premises Total Destruction, whether or not the damage or
destruction is an insured Loss or was caused by a negligent or willful act of Lessee. In the event, however, that the damage or destruction was caused by Lessee, Lessor shall have the right to recover
Lessor's damages from Lessee except as released and walved in Paragraph 8.8. (See Paragraph 40h.) 

        9.5    Damage Near End of Term.    If at any time during the last six (6) months of the term of this Lease (as
extended by Lessee pursuant to any of Lessee's exercised renewal options), there is damage for which the cost to repair exceeds one (1) month's Base Rent, whether or not an insured Loss, Lessor
may, at Lessor's option, terminate this Lease effective sixty (60) days following the date of occurrence of such damage by giving written notice to Lessee of Lessor's election to do so within thirty
(30) days after the date of occurrence of such damage. Provided, however, if Lessee at that time has an exercisable option to extend this Lease or to purchase the Premises, then Lessee may preserve
this Lease by, within twenty (20) days following the occurrence of the damage, or before the expiration of the time provided in such option for its exercise, whichever is either ("Exercise Period"),
(i) exercising such option and (ii) providing Lessor with any shortage in Insurance proceeds (or adequate assurance thereof) needed to make the repairs. If Lessee duly exercises such
option during said Exercise Period and provides Lessor with funds (or adequate assurance thereof) to cover any shortage in insurance proceeds, Lessor shall, at Lessor's expense repair such damage as
soon as reasonably possible and this Lease shall continue in full force and effect. If Lessee fails to exercise such option and provide such funds or assurance during said Exercise Period, then Lessor
may at Lessor's option terminate this Lease as of the expiration of said sixty (60) day period following the occurrence of such damage by giving written notice to Lessee of
Lessor's election to do so within ten (10) days after the expiration of the Exercise Period, notwithstanding any term or provision in the grant of option to the contrary. 

        9.6    Abatement of Rent; Lessee's Remedies.    

        (a)   In
the event of damage described in Paragraph 9.2 (Partial Damage—Insured), whether or not Lessor or Lessee repairs or restores the Premises, the Base
Rent, Real Property Taxes, insurance premiums, and other charges, if any, payable by Lessee hereunder for the period during which such damage, its repair or the restoration continues (not to exceed
the period for which rental value insurance is required under Paragraph 8.3(b)), shall be abated in proportion to the degree to which Lessee's use of the Premises is impaired. Except for
abatement of Base Rent, Real Property Taxes, insurance premiums, and other charges, if any, as aforesaid, all other obligations of Lessee hereunder shall be performed by Lessee, and Lessee shall have
no claim against Lessor for any damage suffered by reason of any such repair or restoration. 

        (b)   If
Lessor shall be obligated to repair or restore the Premises under the provisions of this Paragraph 9 and shall not commence, in a substantial and meaningful
way, the repair or restoration of the Premises within ninety (90) days after such obligation shall accrue, Lessee may, at any time prior to the commencement of such repair or restoration, give written
notice to Lessor and to any Lenders of which Lessee has actual notice of Lessee's election to terminate this Lease on a date not less than sixty (60) days following the giving of such notice. If
Lessee gives such notice to Lessor and such Lenders and such repair or restoration is not commenced within thirty (30) days after receipt of such notice, this Lease shall terminate as of the date
specified in said 

13

 

notice.
If Lessor or a Lender commences the repair or restoration of the Premises within thirty (30) days after receipt of such notice, this Lease shall continue in full force and effect, "Commence"
as used in this Paragraph shall mean either the unconditional authorization of the preparation of the required plans, or the beginning of the actual work on the Premises, whichever first occurs. 

        9.7    Hazardous Substance Conditions.    If a Hazardous Substance Condition occurs, unless Lessee is legally
responsible therefore (in which case Lessee shall make the investigation and remediation thereof required by Applicable Law and this Lease shall continue in full force and effect, but subject to
Lessor's rights under Paragraph 13), Lessor may at Lessor's option either (i) investigate and remediate such Hazardous Substance Condition, if required, as soon as reasonably possible at
Lessor's expense, in which event this Lease shall continue in full force and effect, or (ii) if the estimated cost to investigate and remediate such condition exceeds twelve (12) times
the then monthly Base Rent of $100,000, whichever is greater, give written notice to Lessee within thirty (30) days after receipt by Lessor of knowledge of the occurrence of such Hazardous Substance
Condition of Lessor's desire to terminate this Lease as of the date sixty (60) days following the giving of such notice. In the event Lessor elects to give such notice of Lessor's intention to
terminate this Lease, Lessee shall have the right within ten (10) days after the receipt of such notice to give written notice to Lessor of Lessee's commitment to pay for the investigation and
remediation of such Hazardous Substance Condition totally at Lessee's
expense and without reimbursement from Lessor except to the extent of an amount equal to twelve (12) times the then monthly Base Rent or $100,000, whichever is greater. Lessee shall provide Lessor
with the funds required of Lessee or satisfactory assurance thereof within thirty (30) days following Lessee's said commitment. In such event this Lease shall continue in full force and effect, and
Lessor shall proceed to make such investigation and remediation as soon as reasonably possible and the required funds are available. If Lessee does not give such notice and provide the required funds
or assurance thereof within the times specified above, this Lease shall terminate as of the date specified in Lessor's notice of termination. If a Hazardous Substance Condition occurs for which Lessee
is not legally responsible, there shall be abatement of Lessee's obligations under this Lease to the same extend as provided in Paragraph 9.8(a) for a period of not to exceed twelve months. 

        9.8    Termination—Advance Payments.    Upon termination of this Lease pursuant to this
Paragraph 9, an equitable adjustment shall be made concerning advance Base Rent and any other advance payments made by Lessee to Lessor. Lessor shall, in addition, return to Lessee so much of
Lessee's Security Deposit as has not been, or is not then required to be, used by Lessor under the terms of this Lease. 

        9.9    Waive Statutes.    Lessor and Lessee agree that the terms of this Lease shall govern the effect of any damage
to or destruction of the Premises with respect to the termination of this Lease and hereby waive the provisions of any present or future statues to the extent inconsistent herewith. 

10.   Real Property Taxes.  

        10.1    (a)    Payment of Taxes.    Lessee shall pay the Real Property Taxes, as defined in
Paragraph 10.2, applicable to the Premises during the term of this Lease. Subject to Paragraph 10.1(b), all such payments shall be made at least ten (10) days prior to the delinquency
date of the applicable installment. Lessee shall promptly furnish Lessor with satisfactory evidence that such taxes have been paid. If any such taxes to be paid by Lessee shall cover any period of
time prior to or after the expiration or earlier termination of the term hereof, Lessee's share of such taxes shall be equaitably prorated to cover only the period of time within the tax fiscal year
this Lease is in effect, and Lessor shall reimburse Lessee for any over payment after such proration. If Lessee shall fall to pay any Real Property Taxes required by this Lease to be paid by Lessee,
Lessor shall have the right to pay the same, and Lessee shall reimburse Lessor therefore upon demand. 

14

 

        (b)    Advance Payment.    In order to insure payment when due and
before delinquency of any or all Real Property Taxes, Lessor reserves the right, at Lessor's option, to estimate the current Real Property Taxes applicable to the Premises, and to require such current
year's Real. Property Taxes to be paid in advance to Lessor by Lessee, monthly, in advance with the payment of the Base Rent If Lessor effects to require payment monthly in advance, the monthly
payment shall be that equal monthly amount which, over the number of months remaining before the month in which the applicable tax installment would become delinquent (and without interest thereon),
would provide a fund large enough to fully discharge before delinquency the estimated installment of taxes to be paid. When the actual amount of the applicable tax bill is known, the amount of such
equal monthly advance payment shall be adjusted as required to provide the fund needed to pay the applicable taxes before delinquency. If the amounts paid to Lessor by Lessee under the provisions of
this Paragraph are insufficient to discharge the obligations of Lessee to pay such Real Property Taxes as the same become due, Lessee shall pay to Lessor, upon Lessor's demand, such additional sums as
are necessary to pay such obligations. All moneys paid to Lessor under this Paragraph may be intermingled with other moneys of Lessor and shall not bear interest. In the event of a Breach by Lessee in
the performance of the obligations of Lessee under this Lease, then any balance of funds paid to Lessor under the provisions of this Paragraph may, subject to proration as provided in
Paragraph 10.1(a), at the option of Lessor, be treated as an additional Security Deposit under Paragraph 5. 

        10.2    Definition of "Real Property."    As used herein, the term "Real Property Taxes" shall include any form of
real estate tax of assessment, general, special, ordinary or extraordinary, and any license fee, commercial rental tax, improvement bond or bonds, levy or tax (other than inheritance, personnel income
or estate taxes) imposed upon the Premises by any authority having the direct or indirect power to tax, including any city, state or lederal government, or any school, agricultural, sanitary, fire,
street, drainage or other improvement district thereof, levied against any legal or equitable interest of Lessor in the Premises or in the real property of which the Premises are a part Lessor's right
to rent or other income therefrom, and/or Lessor's business of leasing the Premises. The term "Real Property Taxes" shall also include any tax fees, levy, assessment or charge, or any increase
therein, imposed by reason of events occurring, or charges in applicable law taking effect, during the term of this Lease, including but not limited to a change in the ownership of the Premises or in
the improvements thereon after the first two (2) years of the original Lease term only the execution of this Lease, or any modification, amendment or transfer thereof, and whether or not
contemplated by the Parties. (See Paragraph 49l) 

        10.4    Personal Property Taxes.    Subject to Lessee's legal right to contest the amount or applicability of such
taxes, Lessee shall pay prior to delinquency all taxes assessed against and levied upon Lessee Owned Alterations, Utility Installations, Trade Fixtures, furnishings, equipment and all personal
property of Lessee contained in the Premises or elsewhere. When possible, Lessee shall cause its Trade Fixtures, furnishings, equipment and all other personal property to be assessed and billed
separately from the real property of Lessor. If any of Lessee's said personal property shall be assessed with Lessor's real property, Lessee shall pay Lessor the taxes attributable to Lessee within
ten (10) days after receipt of a written statement setting forth the taxes applicable to Lessee's property or, at Lessor's option, as provided in Paragraph 10.1(b). 

11.    Utilities.    Lessee shall pay for all water, gas, heat, light, power,
telephone, trash disposal and other utilities and services supplied to the Premises, together with any taxes thereon. If any such services are not separately metered to Lessee, Lessee shall pay a
reasonable proportion, to be determined by Lessor, of all charges jointly metered with other premises. 

15

   12.   Assignment and Subletting.  

        12.1    Lessor's Consent Required.    

        (a)   Lessee
shall not voluntarily or by operation of law assign, transfer, mortgage or otherwise transfer or encumber (collectively,  "assignment") or sublet all or any part of Lessee's interest in this Lease or in
the Premises without Lessor's prior written consent given under and
subject to the terms of Paragraph 36. 

        (b)   A
change in the control of Lessee shall constitute an assignment requiring Lessor's consent. The transfer, on a cumulative basis, of twenty-five percent
(25%) or more of the voting control of Lessee shall constitute a change in control for this purpose. (See Paragraph 49j.) 

        (c)   The
involvement of Lessee or its assets in any transaction, or series of transactions (by way of merger, sale, acquisition, financing, refinancing, transfer, leveraged
buy-out or otherwise), whether or not a formal assignment or hypothecation of this Lease or Lessee's assets occurs, which results or will result in a reduction of the Net Worth of Lessee,
as hereinafter defined, by an amount equal to or greater than twenty-five percent (25%) of such Net Worth of Lessee as it was represented to Lessor at the time of the execution by Lessor
of this Lease or at the time of the most recent assignment to which Lessor has consented, or as it exists immediately prior to said transaction or transactions constituting such reduction, at
whichever time said Net Worth of Lessee was or is greater, shall be considered an assignment of this Lease by Lessee to which Lessor may reasonably withhold its consent. "Net Worth of Lessee" for
purposes of this Lease shall be the net worth of Lessee established under generally accepted accounting principles consistently applied. 

        (d)   An
assignment or subletting of Lessee's interest in this Lease without Lessor's specific prior written consent shall at Lessor's option, be a Default curable after
notice per Paragraph 13.1(c), or a noncurable Breach without the necessity of any notice and grace period. If Lessor elects to treat such unconsented to assignment or subletting as a noncurable
Breach, Lessor shall have the right to either: (i) terminate this Lease, or (ii) upon thirty (30) days written notice ("Lessor's Notice"), increase the monthly Base Rent to fair market
rental value or one hundred ten percent (110%) of the Base Rent then in effect, whichever in greater. Pending determination of the new fair market rental value, if
disputed by Lessee, Lessee shall pay the amount set forth in Lessor's Notice, with any overpayment credited against the next installment(s) of Base Rent coming due, and any underpayment for the period
retroactively to the effective date of the adjustment being due and payable immediately upon the determination thereof. Further, in the event of such Breach and market value adjustment, (i) the
purchase price of any option to purchase the Premises held by Lessee shall be subject to similar adjustment to the then fair market value (without the Lessee being considered an encumbrance or any
deduction for depreciation or obsolescence, and considering the Premises at its highest and best use and in good condition), or one hundred ten percent (110%) of the price previously in effect,
whichever is greater, (ii) any index-oriented rental or price adjustment formulas contained in this Lease shall be adjusted to require that the base Index be determined with reference to the
index applicable to the time of such adjustment, and (iii) any fixed rental adjustments scheduled during the remainder of the Lease term shall be increased in the same ratio as the new market
rental bears to the Base Rent in effect immediately prior to the market value adjustment. 

        12.2    Terms and Conditions Applicable to Assignment and Subletting.    

        (a)   Regardless
of Lessor's consent, any assignment or subletting shall not: (i) be effective without the express written assumption by such assignee or sublessee of
the obligations of Lessee under this Lease, (ii) release Lessee of any obligations hereunder, or (iii) after the primary liability of Lessee for the payment of Base Rent and other sums
due Lessor hereunder or for the performance of any other obligations to be performed by Lessee under this Lease. 

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        (b)   Lessor
may accept any rent or performance of Lessee's obligations from any person other than Lessee pending approval or disapproval of an assignment. Neither a delay in
the approval or disapproval of such assignment nor the acceptance of any rent or performance shall constitute a waiver or estoppel of Lessor's right to exercise its remedies for the Default or Breach
by Lessee of any of the terms, covenants of conditions of this Lease. 

        (c)   The
consent of Lessor to any assignment or subletting shall not constitute a consent to any subsequent assignment or subletting by Lessee or to any subsequent or
successive assignment or subletting by the sublessee. However, Lessor may consent to subsequent sublettings and assignments of the sublease or any amendments or modifications thereto without notifying
Lessee or anyone else liable on the Lease or sublease and without obtaining their consent, and such action shall not relieve such persons from liability under this Lease or sublease. 

        (d)   In
the event of any Default or Breach of Lessee's obligations under this Lease, Lessor may proceed directly against Lessee, any Guarantors or any one else responsible
for the performance of the Lessee's obligations under this Lease, including the sublessee, without first exhausting Lessor's remedies against any other person or entity responsible therefor to Lessor,
or any security held by Lessor or Lessee. 

        (e)   Each
request for consent to an assignment or subletting shall be in writing, accompanied by information relevant to Lessor's determination as to the financial and
operational responsibility and appropriateness of the proposed assignee or sublessee, including but not limited to the intended use and/or required modification of the Premises, if any, together with
a deposit of $2,000 for actual costs not to exceed such amount, as reasonable consideration for Lessor's considering and processing the request for consent. Lessee agrees to provide Lessor with such
other or additional information and/or documentation as may be reasonably requested by Lessor. 

        (f)    Any
assignee of, or sublessee under, this Lease shall, by reason of accepting such assignment or entering into such sublease, be deemed, for the benefit of Lessor, to
have assumed and agreed to conform and comply with each and every term, covenant, condition and obligation herein to be observed or performed by Lessee during the term of said assignment or sublease,
other than such obligations as are contrary to or inconsistent with provisions of an assignment or sublease to which Lessor has specifically consented in writing. 

        (h)   Lessor,
as a condition to giving its consent to any assignment or subletting of the entire Premises, may require that the amount and adjustment structure of the rent
payable under this Lease be adjusted to what is then the market value and/or adjustment structure for property similar to the Premises as then constituted. 

        12.3    Additional Terms and Conditions Applicable to Subletting.    The following terms and conditions shall apply to
any subletting by Lessee of all or any part of the Premises and shall be deemed included in all subleases under this Lease whether or not expressly incorporated therein. 

        (a)   Lessee
hereby assigns and transfers to Lessor all of Lessee's interest in all rentals and income arising from any sublease of all or a portion of the Premises heretofore
or hereafter made by Lessee, and Lessor may collect such rent and income and apply same toward Lessee's obligations under this Lease; provided, however, that until a Breach (as defined in
Paragraph 13.1)) shall occur in the performance of Lessee's obligations under this Lease, Lessee may, except as otherwise provided in this Lease, receive, collect and enjoy the rents accruing
under such sublease. Lessor shall not, by reason of this or any other assignment of such sublease to Lessor, nor by reason of the collection of the rents from a sublessee, be deemed liable to the
sublessee for any failure of Lessee to perform and comply with any of Lessee's obligations to such sublessee under such sublease. Lessee hereby irrevocably authorizes and directs any such sublessee,
upon uncured Breach in the performance of Lessee's obligations under this Lease, to pay to 

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Lessor
the rents and other charges due and to become due under the sublease. Sublessee shall pay such rents and other charges to Lessor notwithstanding any notice from or claim from Lessee to the
contrary. Lessee shall have no right or claim against said sublessee, or, until the Breach has been cured, against Lessor, for any such rents and other charges so paid by said sublessee to Lessor. 

        (b)   In
the event of a Breach by Lessee in the performance of its obligations under this Lease, Lessor, at its option and without any obligation to do so, may require any
subleased to attorn to Lessor, in which event Lessor shall undertake the obligations of the sublessor under such sublease from the time of the exercise of said option to the expiration of such
sublease; provided, however, Lessor shall not be liable for any prepaid rents or security deposit paid by such sublessee to such sublessor or for any other prior Defaults or Breaches of such sublessor
under such sublease. 

        (c)   Any
matter or thing requiring the consent of the sublessor under a sublease shall also require the consent of Lessor herein. 

        (d)   No
sublessee shall further assign or sublet all or any part of the Premises without Lessor's and Lessee's prior written consent. 

        (e)   Lessor
shall deliver a copy of any notice of Default or Breach by Lessee to the sublessee, who shall have the right to cure the Default of Lessee within the grace
period, if any, specified in such notice. The sublessee shall have a right of reimbursement and offset from and against Lessee for any such Defaults cured by the sublessee. 

13.   Default; Breach; Remedies.  

        13.1    Default; Breach.    Lessor and Lessee agree that if an attorney is consulted by Lessor in connection with a
Lessee Default or Breach (as hereinafter defined) $350.00 is a reasonable minimum sum per such occurrence for legal services and costs in the preparation and service of a notice of Default, and that
Lessor may include the cost of such services and costs in said notice as rent due and payable to cure said Default. A "Default" is defined as a failure,
by the Lessee to observe, comply with or perform any of the terms, covenants, conditions or rules applicable to Lessee under this Lease. A "Breach" is
defined as the occurrence of any one or more of the following Defaults, and, where a grace period for cure after notice is specified herein, the failure by Lessee to cure such Default prior to the
expiration of the applicable grace period, and shall entitle Lessor to pursue the remedies set forth in Paragraphs 13.2 and/or 13.3: 

        (a)   The
vacating of the Premises without a Lessor-authorized assignee or sublessee, or without the intention to reoccupy same, or the abandonment of the Premises. 

        (b)   Except
as expressly otherwise provided in this Lease, the failure by Lessee to make any payment of Base Rent or any other monetary payment required to be made by Lessee
hereunder, whether to Lessor or to a third party, as and when due, the failure by Lessee to provide Lessor with reasonable evidence of insurance or surety bond required under this Lease, or the
failure of Lessee to fulfill any obligation under this Lease which endangers or threatens life or property, where such failure continues for a period of three (3) days following written notice thereof
by or on behalf of Lessor to Lessee. 

        (c)   Except
as expressly otherwise provided in this Lease, the failure by Lessee to provide Lessor with reasonable written evidence in duly executed original form, if
applicable) of (i) compliance with applicable law per Paragraph 6.3, (ii) the inspection, maintenance and service contracts required under Paragraph 7.1(b),
(iii) the recission of an unauthorized assignment or subletting per Paragraph 12.1(b), (iv) a Tenancy Statement per Paragraphs 16 or 37, (v) the subordination or
non-subordination of this Lease per Paragraph 30, (vi) the guaranty of the performance of Lessee's obligations under this Lease if required under Paragraphs 1.11 and
37, 

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(vii) the
execution of any document requested under Paragraph 42 (easements), or (viii) any other documentation or information which Lessor may reasonably require of Lessee under
the terms of this Lease, where any such failure continues for a period of ten (10) days following written notice by or on behalf of Lessor to Lessee. 

        (d)   A
Default by Lessee as to the terms, covenants, conditions or provisions of this Lease, or of the rules adopted under Paragraph 40 hereof, that are to be
observed, compiled with or performed by Lessee, other than these described in subparagraphs (a), (b) or (c), above, where such Default continues for a period of thirty (30) days after written
notice thereof by or on behalf of Lessor to Lessee; provided, however, that if the nature of Lessee's Default is such that more than thirty (30) days are reasonably required for its cure, then it
shall not be deemed to be a Breach of this Lease by Lessee if Lessee commences such cure within said thirty (30) day period and thereafter diligently prosecutes such cure to completion. 

        (e)   The
occurrence of any of the following events: (i) The making by Lessee of any general arrangement or assignment for the benefit of creditors;
(ii) Lessee's becoming a "debtor" as defined in 11 U.S.C. Section 101 or any successor statute thereto (unless, in the case of a petition filed against Lessee, the same is
dismissed within one hundred twenty (120) days); (iii) the appointment of a trustee or receiver to take possession of substantially all of Lessee's assets located at the Premises or of Lessee's
interest in this Lease, where possession is not restored to Lessee within thirty (30) days; or (iv) the attachment, execution or other judicial seizure of substantially all of Lessee's assets
located at the Premises or of Lessee's interest in this Lease, where such seizure is not discharged within thirty (30) days; provided, however, in the event that any provision of this
subparagraph (e) is contrary to any applicable law such provision shall be of no force or effect, and not affect the validity of the remaining provisions. 

        (f)    The
discovery by Lessor that any financial statement given to Lessor by Lessee or any Guarantor of Lessee's obligations hereunder was materially false. 

        13.2    Remedies.    If Lessee fails to perform any affirmative duty or obligation of Lessee under this Lease, within
ten (10) days after notice to Lessee (or in case of an emergency, without notice), Lessor may at its option (but without obligation to do so), perform such duty or obligation on Lessee's behalf,
including but not limited to the obtaining of reasonably required bonds, insurance policies, or governmental licenses, permits or approvals. The costs and expenses of any such performance by Lessor
shall be due and payable by Lessee to Lessor upon invoice therefor. If any three (3) checks given to Lessor by Lessee shall not be honored by the bank upon which it is drawn, Lessor, at its option,
may require all future payments to be made under this Lease by Lessee to be made only by cashier's check. In the event of a Breach of this Lease by Lessee, as defined in Paragraph 13.1, with or
without further notice or demand, and without limiting Lessor in the exercise of any right or remedy which Lessor may have by reason of such Breach, Lessor may: 

        (a)   Terminate
Lessee's right to possession of the Premises by any lawful means, in which case this Lease and the term hereof shall terminate and Lessee shall immediately
surrender possession of the Premises to Lessor. In such event Lessor shall be entitled to recover from Lessee: (i) the worth at the time of the award of the unpaid rent which had been earned at
the time of termination; (ii) the worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time of award exceeds the amount of
such rental loss that the Lessee proves could have been reasonably avoided; (iii) the worth at the time of award of the amount by which the unpaid rent for the balance of the term after the
time of award exceeds the amount of such rental loss that the Lessee proves could be reasonably avoided; and (iv) any other amount necessary to compensate Lessor for all the detriment
proximately caused by the Lessee's failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom, including but not limited to the
cost of 

19

 

recovering
possession of the Premises, expenses of reletting, including necessary renovation and alteration of the Premises, to a condition required by subparagraph 7.4(c), reasonable
attorneys' fees, and that portion of the leasing commission paid by Lessor applicable to the unexpired term of this Lease. The worth at the time of award of the amount referred to in provision
(iii) of the prior sentence shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent. Efforts by
Lessor to mitigate damages caused by Lessee's Default or Breach of this Lease shall not waive Lessor's right to recover damages under this Paragraph. If termination of this Lease is obtained through
the provisional remedy of unlawful detainer, Lessor shall have the right to recover in such proceeding the unpaid rent and damages as are recoverable therein, or Lessor may reserve therein the right
to recover all or any part thereof in a separate suit for such rent and/or damages. If a notice and grace period required under subparagraphs 13.1(b), (c) or (d) was not previously given a
notice to pay rent or quit, or to perform or quit, as the case may be, given to Lessee under any statute authorizing the forfeiture of leases for unlawful detainer shall also constitute the applicable
notice for grace period purposes required by subparagraphs 13.1(b), (c) or (d). In such case, the applicable grace period under subparagraphs 13.1(b), (c) or (d) and under the unlawful
detainer statute shall run concurrently after the one such statutory notice, and the failure of Lessee to cure the Default within the greater of the two such grace periods shall constitute both an
unlawful detainer and a Breach of this Lease entitling Lessor to the remedies provided for in this Lease and/or by said statute. 

        (b)   Continue
the Lease and Lessee's right to possession in effect (in California under California Civil Code Section 1951.4) after Lessee's Breach and abandonment and
recover the rent as it becomes due, provided Lessee has the right to sublet or assign, subject only to reasonable limitations. See Paragraphs 12 and 38 for the limitations on assignment and
subletting which limitations Lessee and Lessor agree are reasonable. Acts of maintenance or preservation, efforts to relet the Premises, or the appointment of a receiver to protect the Lessor's
interest under the Lease, shall not constitute a termination of the Lessee's right to possession. 

        (c)   Pursue
any other remedy now or hereafter available to Lessor under the laws or judicial decisions of the state wherein the Premises are located. 

        (d)   The
expiration or termination of this Lease and/or the termination of Lessee's right to possession shall not relieve Lessee from liability under any indemnity provisions
of this Lease as to matters occurring or accruing during the term hereof or by reason of Lessee's occupancy of the Premises. 

        13.3    Inducement Recapture in Event of Breach.    Any agreement by Lessor for free or abated rent or other charges
applicable to the Premises, or for the giving or paying by Lessor to or for Lessee of any cash or other bonus, inducement or consideration for Lessee's entering into this Lease, all of which
concessions are hereinafter referred to as "Inducement Provisions" shall be deemed conditioned upon Lessee's full and faithful performance of all of the
terms, covenants and conditions of this Lease to be performed or observed by Lessee during the term hereof as the same may be extended. Upon the occurrence of an uncured Breach of this Lease by
Lessee, as defined in Paragraph 13.1, any such Inducement Provision shall automatically be deemed deleted from this Lease and of no further force or effect, and any rent, other charge, bonus,
Inducement or consideration theretofore abated, given or paid by Lessor under such an Inducement Provision shall be immediately due and payable by Lessee to Lessor, and recoverable by Lessor as
additional rent due under this Lease if such Breach remains uncured after the applicable period available for its cure. 

20

           13.4    Late Charges.    Lessee hereby acknowledges that late payment by Lessee to
Lessor of rent and other sums due
hereunder will cause Lessor to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult to ascertain. Such costs include, but are not limited to, processing
and accounting charges, and late charges which may be imposed upon Lessor by the terms of any ground lease, mortgage or trust deed covering the Premises. Accordingly, if any installment of rent or any
other sum due from Lessee shall not be received by Lessor or Lessor's designee within ten (10) days after such amount shall be due, then, without any requirement for notice to Lessee, Lessee shall pay
to Lessor a late charge equal to six percent (6%) of such overdue amount. The parties hereby agree that such late charge represents a fair and reasonable estimate of the costs Lessor will incur by
reason of late payment by Lessee. Acceptance of such late charge by Lessor shall in no event constitute a waiver of Lessee's Default or Breach with respect to such overdue amount, nor prevent Lessor
from exercising any of the other rights and remedies granted hereunder. In the event that a late charge is payable hereunder, whether or not collected, for three (3) consecutive installments of Base
Rent, then notwithstanding Paragraph 4.1 or any other provision of this Lease to the contrary, Base Rent shall, at Lessor's option, become due and payable quarterly in advance. 

        13.5    Breach by Lessor.    Lessor shall not be deemed in breach of this Lease unless Lessor fails within a
reasonable time to perform an obligation required to be performed by Lessor. For purposes of this Paragraph 13.5, a reasonable time shall in no event be less than thirty (30) days after receipt
by Lessor, and by the holders of any ground lease, mortgage or deed of trust covering the Premises whose name and address shall have been furnished Lessee in writing for such purpose, of written
notice specifying wherein such obligation of Lessor has not been performed; provided, however, that if the nature of Lessor's obligation is such that more than thirty (30) days after such notice are
reasonably required for its performance, then Lessor shall not be in breach of this Lease if performance is commenced within such thirty (30) day period and thereafter diligently pursued to
completion. 

14.    Condemnation.    If the Premises or any portion thereof are taken under the
power of eminent domain or sold under the threat of the exercise of said power (all of which are herein called "condemnation"), this Lease shall
terminate as to the part so taken as of the date the condemning authority takes title or possession, whichever first occurs. If more than ten percent (10%) of the floor area of the Premises, or more
than twenty-five percent (25%) of the land area not occupied by any building, is taken by condemnation, Lessee may, at Lessee's option, to be exercised in writing within thirty (30) days
after Lessor shall have given Lessee written notice of such taking (or in the absence of such notice, within thirty (30) days after the condemning authority shall have taken possession) terminate this
Lease as of the date the condemning authority takes such possession. If Lessee does not terminate this Lease in accordance with the foregoing, this Lease shall remain in full force and effect as to
the portion of the Premises remaining, except that the Base Rent shall be reduced in the same proportion as the rentable floor area of the Premises taken bears to the total rentable floor area of the
building located on the Premises. No reduction of Base Rent shall occur if the only portion of the Premises taken is land on which there is no building. Any award for the taking of all or any part of
the Premises under the power of eminent domain or any payment made under threat of the exercise of such power shall be the property of Lessor, whether such award shall be made as compensation for
diminution in value of the leasehold or for the taking of the fee, or as severance damages; provided, however, that Lessee shall be entitled to any compensation, separately awarded to Lessee for
Lessee's relocation expenses and/or loss of Lessee's Trade Fixtures and Lessee owned Alterations or Utility Installations which Lessee would otherwise be entitled to remove. In the event that this
Lease is not terminated by reason of such condemnation, Lessor shall be to the extent of its net severance damages received, over and above the legal and other expenses incurred by Lessor in the
condemnation matter, repair any damage to the Premises caused by such condemnation, except to the extent that Lessee has been reimbursed thereof by the condemning authority. Lessee shall be
responsible for the payment of any amount in excess of such net severance damages required to complete such repair. 

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15.   Broker's Fee.  

        15.1 The Brokers named in Paragraph 1.10 are the procuring causes of this Lease. 

        15.5 Lessee and Lessor each represent and warrant to the other that it has had no dealings with any person, firm, broker or
finder (other than the Brokers, if any named in Paragraph 1.10) in connection with the negotiation of this Lease and/or the consummation of the transaction contemplated hereby, and that no
broker or other person, firm or entity other than said named Brokers is entitled to any commission of finder's fee in connection with said transaction. Lessee and Lessor do each hereby agree to
indemnify, protect, defend and hold the other harmless from and against liability for compensation or charges which may be claimed by any such unnamed broker, finder or other similar party by reason
of any dealings or actions of the indemnifying Party, including any costs, expenses, attorneys' fees reasonably incurred with respect thereto. 

        15.6 Lessor and Lessee hereby commit to and approve all agency relationships, including any dual agencies, indicated in
Paragraph 1.10. 

16.   Tenancy Statement.  

        16.1 Each Party (as "Responding Party") shall within ten (10) days after written notice from the other Party (the
"Requesting Party") execute, acknowledge and deliver to the Requesting Party a statement in writing in form similar to the then most current "Tenancy Statement" form published by the American
Industrial Float Estate Association, plus such additional information, confirmation and/or statements as may be reasonably requested by the Requesting Party. 

        16.2 If Lessor desires to finance, refinance, or sell the Premises, any part thereof, or the building of which the Premises
are a part, Lessee and all Guarantors of Lessee's performance hereunder shall deliver to any potential lender or purchaser designated by Lessor such financial statements of Lessee and such Guarantors
as may be reasonably required by such lender or purchaser, including but not limited to Lessee's financial statements for the past three (3) years. All such financial statements shall be received by
Lessor and such lender or purchaser in confidence and shall be used only for the purposes herein set forth. 

17.    Lessor's Liability.    The term "Lessor" as used herein shall mean the owner
or owners at the time in question of the fee title to the Premises, or, if this is a sublease, of the lessee's interest in the prior lease, in the event of a transfer of Lessor's title or interest in
the Premises or in this Lease. Lessor shall deliver to the transferee or assignee (in cash or by credit) any unused Security Deposit held by Lessor at the time of such transfer or assignment. Except
as provided in Paragraph 15, upon such transfer or assignment and delivery of the Security Deposit, as aforesaid, the prior Lessor shall be relieved of all liability with respect to the
obligations and/or covenants under this Lease thereafter to be performed by the Lessor. Subject to the foregoing, the obligations and/or covenants in this Lease to be performed by the Lessor shall be
binding only upon the Lessor as hereinabove defined. 

18.    Severability.    The invalidity of any provision of this Lease, as determined
by a court of competent jurisdiction, shall in no way affect the validity of any other provision hereof. 

19.    Interest on Past-Due Obligations.    Any monetary payment due
Lessor hereunder, other than late charges, not received by Lessor within thirty (30) days following the date on which it was due, shall bear interest from the thirty-first (31st) day after it was due
at the rate of 12% per annum, but not exceeding the maximum rate allowed by law, in addition to the late charge provided for in Paragraph 13.4. 

20.    Time of Essence.    Time is of the essence with respect to the performance of
all obligations to be performed or observed by the Parties under this Lease. 

21.    Rent Defined.    All monetary obligations of Lessee to Lessor under the terms
of this Lease are deemed to be rent. 

22

 

22.    No Prior or Other Agreements; Broker Disclaimer.    This Lease contains all
agreements between the Parties with respect to any matter mentioned herein, and no other prior or contemporaneous agreement or understanding shall be effective. Lessor and Lessee each represents and
warrants to the Brokers that it has made, and is relying solely upon, its own investigation as to the nature, quality, character and financial responsibility of the other Party to this Lease and as to
the nature, quality and character of the Premises. Brokers have no responsibility with respect thereto or with respect to any default or breach hereof by either Party. 

23.   Notices.  

        23.1 All notices required or permitted by this Lease shall be in writing and may by delivered in person (by hand or by
messenger or courier service) or may by sent by regular, certified or registered mail or U.S. Postal Service Express Mail, with postage prepaid, or by facsimile transmission, and shall be deemed
sufficiently given if served in a manner specified in this Paragraph 23. The addresses noted adjacent to a Party's signature on this Lease shall be that Party's address for delivery or mailing
of notice purposes. Either Party may by written notice to the other specify a different address for notice purposes, except that upon Lessee's taking possession of the Premises, the Premises shall
constitute Lessee's address for the purpose of mailing or delivering notices to Lessee. A copy of all notices required or permitted to be given to either party hereunder shall be concurrently
transmitted to such party or parties at such addresses as such party may from time to time hereafter designate by written notice to either party. 

        23.2 Any notice sent by registered or certified mail, return receipt requested, shall be deemed given on the date of delivery
shown on the receipt card, or if no delivery date is shown, the postmark thereon. If sent by regular mail the notice shall be deemed given seventy-two (72) hours after the same is
addressed as required herein and mailed with postage prepaid. Notices delivered by United States Express Mail or overnight courier that guarantees next day delivery shall be deemed given
twenty-four (24) hours after delivery of the same to the United States Postal Service or courier. If any notice is transmitted by facsimile transmission or similar means, the same
shall be deemed served or delivered upon telephone confirmation of receipt of the transmission thereof, provided a copy is also delivered via delivery or mail. If notice is received on a Sunday or
legal holiday, it shall be deemed received on the next business day. 

24.    Waivers.    No waiver by Lessor of the Default or Breach of any term,
covenant or condition hereof by Lessee, shall be deemed a waiver of any other term, covenant or condition hereof, or of any subsequent Default or Breach by Lessee of the same or of any other term,
covenant or condition hereof. Lessor's consent to, or approval of, any act shall not be deemed to render unnecessary the obtaining of Lessor's consent to, or approval of, any subsequent or similar act
by Lessee, or be construed as the basis of an estoppel to enforce the provision or provisions of this Lease requiring such consent. Regardless of Lessor's knowledge of a Default or Breach at the time
of accepting rent, the acceptance of rent by Lessor shall not be a waiver of any preceding Default or Breach by Lessee of any provision hereof, other than the failure of Lessee to pay the particular
rent so accepted. Any payment given Lessor by Lessee may be accepted by Lessor on account of moneys or damages due Lessor, notwithstanding any qualifying statements or conditions made by Lessee in
connection therewith, which such statements and/or conditions shall be of no force or effect whatsoever unless specifically agreed to in writing by Lessor at or before the time of deposit of such
payment. 

25.    Recording.    Either Lessor or Lessee shall, upon request of the other,
execute, acknowledge and deliver to the other a short form memorandum of this Lease for recording purposes. The Party requesting recordation shall be responsible for payment of any fees or taxes
applicable thereto. 

26.    No Right To Holdover.    Lessee has no right to retain possession of the
Premises or any part thereof beyond the expiration or earlier termination of this Lease. 

23

   27.    Cumulative Remedies.    No remedy or election hereunder shall be
deemed
exclusive but shall, wherever possible, be cumulative with all other remedies at law or in equity. 

28.    Covenants and Conditions.    All provisions of this Lease to be observed or
performed by Lessee are both covenants and conditions. 

29.    Binding Effect; Choice of Law.    This Lease shall be binding upon the
parties, their personal representatives, successors and assigns and be governed by the laws of the State in which the Premises are located. Any litigation between the Parties hereto concerning this
Lease shall be initiated in the county in which the Premises are located. 

30.   Subordination; Attornment; Non-Disturbance. 

        30.1    Subordination.    This Lease and any Option granted hereby shall be subject and subordinate to any ground
lease, mortgage, deed of trust, or other hypothecation or security device (collectively, "Security Device"), now or hereafter placed by Lessor upon the real property of which the Premises are a part,
to any and all advances made on the security thereof, and to all renewals, modifications, consolidations, replacements and extensions thereof. Lessee agrees that the Lenders holding any such Security
Device shall have no duty, liability or obligation to perform any of the obligations of Lessor under this Lease, but that in the event of Lessor's default with respect to any such obligation, Lessee
will give any Lender whose name and address have been furnished Lessee in writing for such purpose notice of Lessor's default and allow such Lender thirty (30) days following receipt of such notice
for the cure of said default before invoking any remedies Lessee may have by reason thereof. If any Lender shall elect to have this Lease and/or any Option granted hereby superior to the lien of its
Security Device and shall give written notice thereof to Lessee, this Lease and such Options shall be deemed prior to such Security Device, notwithstanding the relative dates of the documentation or
recordation thereof. 

        30.2    Attornment.    Subject to the non-disturbance provisions of Paragraph 30.3, Lessee agrees
to attorn to a Lender or any other party who acquires ownership of the Premises by reason of a foreclosure of a Security Device, and that in the event of such foreclosure, such new owner shall not
(i) be liable for any act or omission of any prior lessor or with respect to events occurring prior to acquisition of ownership, (ii) be subject to any offsets or defenses which Lessee
might have against any prior lessor, or (iii) be bound by prepayment of more than one month's rent. 

        30.3    Non-Disturbance.    With respect to Security Devices entered into by Lessor after the execution of
this Lease, Lessee's subordination of this Lease shall be subject to receiving assurance in a form generally in use by commercial lenders (a "non-disturbance agreement") from the Lender
that Lessee's possession and this Lease, including any options to extend the term hereof, will not be disturbed so long as Lessee is not in Breach hereof and attorns to the record owner of the
Premises. 

        30.4    Self-Executing.    The agreements contained in this Paragraph 30 shall be effective without
the execution of any further documents; provided, however, that upon written request from Lessor as a Lender in connection with a sale, financing or refinancing of the Premises, Lessee and Lessor
shall execute such further writings as may be reasonably required to separately document any such subordination or non-subordination, attornment and/or non-disturbance
agreement as is provided for herein. 

31.    Attorney's Fees.    If any Party or Broker brings an action or proceeding to
enforce the terms hereof or declare rights hereunder, the Prevailing Party (as hereafter defined) or Broker in any such proceeding, action, or appeal thereon, shall be entitled to reasonable
attorney's fees. Such fees may be awarded in the same suit or recovered in a separate suit, whether or not such action or proceeding is pursued to decision or judgment. The term, "Prevailing Party"
shall include, without limitation, a Party or Broker who substantially obtains or defeats the relief sought, as the case may be, whether by 

24

 

compromise,
settlement, judgment, or the abandonment by the other Party or Broker of its claim or defense. The attorney's fee award shall not be computed in accordance with any court fee schedule, but
shall be such as to fully reimburse all attorney's fees reasonably incurred. Lessor shall be entitled to attorney's fees, costs and expenses incurred in the preparation and service of notices of
Default and consultations in connection therewith, whether or not a legal action is subsequently commenced in connection with such Default or resulting Breach. 

32.    Lessor's Access; Showing Premises; Repairs.    Lessor and Lessor's agents
shall have the right to enter the Premises at any time, in the case of an emergency, and otherwise at reasonable times upon twenty-four (24) hours' prior notice for the purpose of showing the
same to prospective purchasers, lenders, or (during the last nine (9) months of the Lease term) lessees, and making such alterations, repairs, improvements or additions to the Premises or to the
building of which they are a part, as Lessor may reasonably deem necessary. Lessor may at any time place on or about the Premises or building any ordinary "For Sale" signs and Lessor may at any time
during the last one hundred twenty (120) days of the term hereof place on or about the Premises any ordinary "For Lease" signs. All such activities of Lessor shall be without abatement of rent
or liability to Lessee. (See Paragraph 40k) 

33.    Auctions.    Lessee shall not conduct, nor permit to be conducted, either
voluntarily or involuntarily, any auction upon the Premises without first having obtained Lessor's prior written consent. Notwithstanding anything to the contrary in this Lease, Lessor shall not be
obligated to exercise any standard of reasonableness in determining whether to grant such consent. 

34.    Signs.    Lessee shall not place any sign upon the Premises, except that
Lessee may, with Lessor's prior written consent install (but not on the roof) such signs as are reasonably required to advertise Lessee's own business. The installation of any sign on the Premises by
or for Lessee shall be subject to the provisions of Paragraph 7 (Maintenance, Repairs, Utility Installations, Trade Fixtures and Alterations). (See Paragraph 40l) 

35.    Termination; Merger.    Unless specifically stated otherwise in writing by
Lessor, the voluntary or other surrender of this Lease by Lessee, the mutual termination or cancellation hereof, or a termination hereof by Lessor for Breach by Lessee, shall automatically terminate
any sublease or lesser estate in the Premises; provided, however, Lessor shall, in the event of any such surrender, termination or cancellation, have the option to continue any one or all of any
existing subtenancies. Lessor's failure within ten (10) days following any such event to make a written election to the contrary by written notice to the holder of any such lesser interest,
shall constitute Lessor's election to have such event constitute the termination of such interest. 

36.   Consents. 

        (a)   Except
for Paragraph 33 hereof (Auctions) or as otherwise provided herein, wherever in this Lease the consent of a Party is required to an act by or for the other
Party, such consent shall not be unreasonably withheld or delayed. Lessor's actual reasonable costs and expenses (including but not limited to architects', attorneys', engineers' or other consultants'
fees) incurred in the consideration of, or response to a request by Lessee for any Lessor consent pertaining to this Lease or the Premises, including but not limited to consents to an assignment, a
subletting or the presence or use of a Hazardous Substance, practice or storage tank, shall be paid by Lessee to Lessor upon receipt of an invoice and supporting documentation therefor. Subject to
Paragraph 12.2(c) (applicable to assignment or subletting), Lessor may, as a condition to considering any such request by Lessee, require that Lessee deposit with Lessor an amount of money (in
addition to the Security Deposit held under Paragraph 5) reasonably calculated by Lessor to represent the cost Lessor will incur in considering and responding to Lessee's request. Except as
otherwise provided, any unused portion of said deposit shall be refunded to Lessee 

25

 

without
interest. Lessor's consent to any act, assignment of this Lease or subletting of the Premises by Lessee shall not constitute an acknowledgment that no Default or Breach by Lessee of this Lease
exists, nor shall such consent be deemed a waiver of any then existing Default or Breach, except as may be otherwise specifically stated in writing by Lessor at the time of such consent. 

        (b)   All
conditions to Lessor's consent authorized by this Lease are acknowledged by Lessee as being reasonable. The failure to specify herein any particular condition to
Lessor's consent shall not preclude the imposition by Lessor at the time of consent of such further or other conditions as are then reasonable with reference to the particular matter for which consent
is being given. 

38.    Quiet Possession.    Upon payment by Lessee of the rent for the Premises and
the observance and performance of all of the covenants, conditions and provisions on Lessee's part to be observed and performed under this Lease, Lessee shall have quiet possession of the Premises for
the entire term hereof subject to all of the provisions of this Lease. 

39.   Options. 

        39.1    Definition.    As used in this Paragraph 39 the word "Option" has the following meaning: (a) the
right to extend the term of this Lease or to renew this Lease or to extend or renew any lease that Lessee has on other property of Lessor; (b) the right of first refusal to lease the Premises
or the right of first offer to lease the Premises or the right of first refusal to lease other property of Lessor or the right of first offer to lease other property of Lessor; (c) the right to
purchase the Premises, or the right of first refusal to purchase the Premises, or the right of first offer to purchase the Premises, or the right to purchase other property of Lessor, or the right of
first refusal to purchase other property of Lessor, or the right of first offer to purchase other property of Lessor. 

        39.2    Options Personal To Original Lessee.    Each Option granted to Lessee in this Lease is personal to the
original Lessee named in Paragraph 1.1 hereof, and cannot be voluntarily or involuntarily assigned or exercised by any person or entity other than said original Lessee while the original Lessee
is in full and actual possession of the Premises and without the intention of thereafter assigning of subletting. The Options, if any, herein granted to Lessee are not assignable, either as a part of
an assignment of this Lease or separately or apart thereform, and no Option may be separated from this Lease in any manner, by reservation or otherwise provided, however, that the Options may be
assigned to and exercised by any Lessee Affiliate. 

        39.3    Multiple Options.    In the event that Lessee has any multiple Options to extend or renew this Lease, a later
option cannot be exercised unless the prior Options to extend or renew this Lease have been validity exercised. 

        39.4    Effect of Default on Options.    

        (a)   Lessee
shall have no right to exercise an Option, notwithstanding any provision in the grant of Option to the contrary: (i) during the period commencing with the
giving of any notice of Default under Paragraph 13.1 and continuing until the noticed Default is cured, or (ii) during the period of time any monetary obligation due Lessor from Lessee
is unpaid (without regard to whether notice thereof is given Lessee), or (iii) during the time Lessee is in Breach of this Lease, or (iv) in the event that Lessor has given to Lessee
three (3) or more notices of Default under Paragraph 13.1, whether or not the Defaults are cured, during the twelve (12) month period immediately preceding the exercise of the
Option. 

        (b)   The
period of time within which an Option may be exercised shall not be extended or enlarged by reason of Lessee's inability to exercise an Option because of the
provisions of Paragraph 39.4(a). 

        (c)   All
rights of Lessee under the provisions of an Option shall terminate and be of no further force or effect, notwithstanding Lessee's due and timely exercise of the
Option, if, after 

26

 

such
exercise and during the term of this Lease, (i) Lessee fails to pay to Lessor a monetary obligation of Lessee for a period of thirty (30) days after such obligation becomes due (without
any necessity of Lessor to give notice thereof to Lessee), or (ii) Lessor gives to Lessee three or more notices of Default under Paragraph 13.1 during any twelve month period, whether or
not the Defaults are cured, or (iii) if Lessee commits a Breach of this Lease. 

40.    Multiple Buildings.    If the Premises are part of a group of buildings
controlled by Lessor, Lessee agrees that it will abide by, keep and observe all reasonable rules and regulations which Lessor may make from time to time for the management, safety, care, and
cleanliness of the grounds, the parking and unloading of vehicles and the preservation of good order, as well as for the convenience of other occupants or tenants of such other buildings and their
invitees, and that Lessee will pay its fair share of common expenses incurred in connection therewith. 

41.    Security Measures.    Lessee hereby acknowledges that the rental payable to
Lessor hereunder does not include the cost of guard service or other security measures, and that Lessor shall have no obligation whatsoever to provide same. Lessee assumes all responsibility for the
protection of the Premises, Lessee, its agents and invitees and their property from the acts of third parties. 

42.    Reservations.    Lessor reserves to itself the right, from time to time, to
grant, without the consent or joinder of Lessee, such easements, rights and dedications that Lessor deems necessary, and to cause the recordation of parcel maps and restrictions, so long as such
easements, rights, dedications, maps and restrictions do not unreasonably interfere with the use of the Premises by Lessee. Lessee agrees to sign any documents reasonably requested by Lessor to
effectuate any such easement rights, dedication, map or restrictions. 

43.    Performance Under Protest.    If at any time a dispute shall arise as to any
amount or sum of money to be paid by one Party to the other under the provisions hereof, the Party against whom the obligation to pay the money is asserted shall have the right to make payment "under
protest" and such payment shall not be regarded as a voluntary payment and there shall survive the right on the part of said Party to institute suit for recovery of such sum. If it shall be adjudged
that there was no legal obligation on the part of said Party to pay such sum or any part thereof, said Party shall be entitled to recover such sum or so much thereof as it was not legally required to
pay under the provisions of this Lease. 

44.    Authority.    If either Party hereto is a corporation, trust or general or
limited partnership, each individual executing this Lease on behalf of such entity represents and warrants that he or she is duly authorized to execute and deliver this Lease on its behalf. If Lessee
is a corporation, trust or partnership, Lessee shall, within thirty (30) days after request by Lessor, deliver to Lessor evidence satisfactory to Lessor of such authority. 

45.    Conflict.    Any conflict between the printed provisions of this Lease and
the typewritten or handwritten provisions shall be controlled by the typewritten or handwritten provisions. 

46.    Offer.    Preparation of this Lease by Lessor or Lessor's agent and
submission of same to Lessee shall not be deemed an offer to lease to Lessee. This Lease is not intended to be binding until executed by all Parties hereto. 

47.    Amendments.    This Lease may be modified only in writing, signed by the
parties in interest at the time of the modification. The parties shall amend this Lease from time to time to reflect any adjustments that are made to the Base Rent or other rent payable under this
Lease. As long as they do not materially change Lessee's obligations hereunder, Lessee agrees to make such reasonable non-monetary modifications to this Lease as may be reasonably required
by an institutional, insurance company, or pension plan Lender in connection with the obtaining of normal financing or refinancing of the property of which the Premises are a part. 

27

 

48.    Multiple Parties.    Except as otherwise expressly provided herein, if more
than one person or entity is named herein as either Lessor or Lessee, the obligations of such multiple parties shall be the joint and several responsibility of all persons or entities named herein as
such Lessor or Lessee. 

LESSOR
AND LESSEE HAVE CAREFULLY READ AND REVIEWED THIS LEASE AND EACH TERM AND PROVISION CONTAINED HEREIN, AND BY THE EXECUTION OF THIS LEASE SHOW THEIR INFORMED AND VOLUNTARY CONSENT THERETO. THE
PARTIES HEREBY AGREE THAT, AT THE TIME THIS LEASE IS EXECUTED, THE TERMS OF THIS LEASE ARE COMMERCIALLY REASONABLE AND EFFECTUATE THE INTENT AND PURPOSE OF LESSOR AND LESSEE WITH RESPECT TO THE
PREMISES. 

IF
THIS LEASE HAS BEEN FILLED IN, IT HAS BEEN PREPARED FOR SUBMISSION TO YOUR ATTORNEY FOR HIS APPROVAL. FURTHER, EXPERTS SHOULD BE CONSULTED TO EVALUATE THE CONDITION OF THE PROPERTY AS TO THE
POSSIBLE PRESENCE OF ASBESTOS, STORAGE TANKS OR HAZARDOUS SUBSTANCES. NO REPRESENTATION OR RECOMMENDATION IS MADE BY THE AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION OR BY THE REAL ESTATE BROKER(S) OR
THEIR AGENTS OR EMPLOYEES AS TO THE LEGAL SUFFICIENCY, LEGAL EFFECT, OR TAX CONSEQUENCES OF THIS LEASE OR THE TRANSACTION TO WHICH IT RELATES: THE PARTIES SHALL RELY SOLELY UPON THE ADVICE OF THEIR
OWN COUNSEL AS TO THE LEGAL AND TAX CONSEQUENCES OF THIS LEASE. IF THE SUBJECT PROPERTY IS LOCATED IN A STATE OTHER THAN CALIFORNIA, AN ATTORNEY FROM THE STATE WHERE THE PROPERTY IS LOCATED SHOULD BE
CONSULTED. 

28

 

The
parties hereto have executed this Lease at the place on the dates specified above to their respective signatures. 

	Executed at	Carlsbad CA	 	Executed at	San Diego, CA
	 	
	 	 	

	on	September 19, 2001	 	on	SEPTEMBER 19, 2001
	 	
	 	 	

	by LESSOR:	 	by LESSEE:
	BLACKMORE AIRPORT CENTRE, A CALIFORNIA LIMITED PARTNERSHIP	 	CANCERVAX CORPORATION
	
	 	

	

By	

/s/ Blackmore Family Partners, a California General Partnership,	
 	

By:	

/s/ DAVID F. HALE
	 	
	 	 	

	Name Printed:	 	 	Name Printed:	David F. Hale
	 	
	 	 	

	Title:	General Partner	 	Title:	President & CEO
	 	
	 	 	

	

By:	

/s/ ALLEN JOSEPH BLACKMORE	
 	

By:	

/s/ WILLIAM R. LARUE
	 	
	 	 	

	Name Printed:	Allen Joseph Blackmore, Trustee of the Blackmore Family Trust, restated 1995,	 	Name Printed:	

William R. LaRue
	 	
	 	 	

	Title:	General Partner	 	Title:	Vice President & CFO
	 	
	 	 	

	Address:	1530 Faraday Ave, Suite 170,	 	Address:	5931 DARWIN CT
	 	
	 	 	

	 	Carlsbad, CA 92008	 	 	CARLSBAD, CA 92008
	 	
	 	 	

	Tel. No. (760) 804-9600 Fax No. (760) 804-9607	 	Tel. No. (760) 431-1550 Fax No. (760) 431-9980

	Mailing Address:	Post Office Box 1810

Rancho Santa Fe, CA 92067	 

NET

	NOTICE:	These forms are often modified to meet changing requirements of law and industry needs. Always write or call to make sure you are utilizing the most current form: American Industrial Real Estate Association,
345 South Figueroa Street, Suite M-1, Los Angeles, CA 90071. (213) 687-6777. Fax No. (213) 687-8816.

[Illegible]

29

  

 
 

ADDENDUM TO STANDARD INDUSTRIAL/COMMERCIAL SINGLE-TENANT LEASE—NET
  BY AND BETWEEN
  BLACKMORE AIRPORT CENTRE, A CALIFORNIA LIMITED PARTNERSHIP, LESSOR
  AND
  CANCERVAX CORPORATION, LESSEE
  DATED
AUGUST 31, 2001    
    

49.    LEASE INSERTIONS:.    The following inserts are hereby incorporated into the Lease where indicated in the
Lease:

	a.)
	Paragraph 3.3.—Delay in Possession. Add the following at the end of Paragraph 3.3: 

If
an event of damage or destruction to the Tenant improvements shall occur during construction of the Tenant improvements (as provided in Exhibit B), then the Rent due hereunder shall be
abated for the period of time that the completion of the Tenant Improvements is delayed due to such damage or destruction. 

	b.)
	Paragraph 6.2 Hazardous Substances.
	i.
	Subparagraph 6.2(c)—Indemnification.    Add the following at the end of Subparagraph 6.2(c): 

Notwithstanding
any other provision of this Lease, Lessor represents that it is unaware of any Hazardous Substances, including but not limited to any solvents, metals, petroleum,
lead-based paint, PCBs, or asbestos in the Building or Premises. Notwithstanding this representation, and in addition to the indemnity provided in Paragraph 6.2(c), Lessor shall
indemnify
and hold Lessee harmless against and from all liability and claims of any kind for loss or damage to Lessee, its employees or agents, and for expenses and fees of Lessee (including but not limited to
costs, expenses and attorneys' fees), incurred, directly or indirectly, as a result of the existence of Hazardous Substances in, on, under or about the Premises as of the commencement of this Lease 

	ii.
	Paragraph 6.2 Clarification of Intent.    Lessor acknowledges that it is not the intent of this Paragraph 6.2
to prohibit Lessee from operating its business for the permitted uses described in Paragraph 1.8. Notwithstanding the fact that the Lessee's use of a Hazardous Substance in the Premises is a
Reportable Use, Lessee may operate it business so long as the use or presence of Hazardous Substances is strictly and properly monitored according to all applicable laws. As a material inducement to
Lessor to allow Tenant to store and use Hazardous Substances in connection with its business, which constitute a Reportable Use, Lessee agrees to deliver to Lessor prior to allowing any such Hazardous
Substances to be located on or about the Premises, a list identifying each type of Hazardous Substances constituting a Reportable Use which will be present on or about the Premises and setting forth
any and all governmental approvals or permits required in connection with the presence of such Hazardous Substances on or about the Premises ("Hazardous Materials List"). Lessee shall deliver to
Lessor an updated Hazardous Materials List at least once a year and shall also deliver an updated list before any new Hazardous Substances are brought onto the Premises or on or before the date Lessee
obtains any additional permits or approvals.  

 

	c.)
	 Paragraph 7.2—Lessor's Obligations.    Add the following at the end of Paragraph 7.2: 

Notwithstanding
the foregoing, Lessee shall be responsible for any damages caused by Lessee's use of the Premises or the design and installation of Lessee's Tenant Improvements. 

	d.)
	 Subparagraph 7.3 (a)—Definitions; Consent Required.    Add the following to the end of Subparagraph 7.3 (a): 

"Alterations"
shall not include the Tenant Improvements as described in Exhibit B. 

30

 
	e.)
	Subparagraph 7.4(c)—Surrender/Restoration.    Add the following at the end of Subparagraph 7.4.(c): 

Any
Trade Fixtures and Equipment purchased by Lessee and installed in the Premises, which Lessee intends to remove from the Premises upon the expiration or earlier termination of this Lease, shall be
separately identified on a list ("Equipment List") to be compiled by Lessee and acknowledged by Lessor prior to installation. The Trade Fixtures and Equipment on the Equipment List shall be and remain
the sole property of Lessee. Said Fixtures and Equipment may be removed from the Premises by Lessee at any time during the term of this Lease and Lessee shall restore the Premises as required in this
Paragraph 7.4. 

	f.)
	 Paragraph 8.7—Indemnity.    Add the following at the end of Paragraph 8.7: 

Lessor
shall indemnify, protect, defend and hold Lessee harmless from and against any and all claims, damages, costs, liens, judgments, penalties, permits, attorney's and consultant's fees, expenses
and/or liabilities (but not including injuries to Lessee's business or for any loss of income or profit therefrom) arising out of the gross negligence or willful misconduct of Lessor or out of any
Default or Breach by Lessor in the performance of any obligation on Lessor's part to be performed under this Lease. 

	g.)
	Paragraph 9.2—Partial Damage—Insured Loss.    Add the following at the end of
Paragraph 9.2: 

Notwithstanding
the foregoing, if Lessor does not receive insurance proceeds because of Lessor's failure to maintain the insurance required pursuant to Paragraph 8.3, Lessor shall have no right
to terminate this Lease as a result of Lessor's failure to receive funds to cover repairs to the Premises. Further, if an event of Partial Damage occurs that is an Insured Loss and Lessor reasonably
estimates that the repair cannot be completed within one year from the commencement of such repair, then prior to the commencement of repair of the damage Lessor shall send a notice to Lessee
indicating that the estimated time to repair the Partial Damage exceeds one (1) year. Upon receipt of such notice, Lessee shall have an option, which option expires five (5) business
days after Lessee's receipt of such notice, in which to give Lessor notice that Lessee has elected to terminate this Lease. If elected, such termination shall become effective at the end of such five
(5) business day period. However, once Lessor commences the repair of the damage following the end of the five (5) business day period, Lessee shall have no further right to terminate
the Lease, regardless of the actual amount of time the repair of the damage actually takes. 

	h.)
	 Paragraph 9.4—Total Destruction:    Add the following to the end of Paragraph 9.4: 

In
the event of a Premises Total Destruction, Lessor shall promptly notify Lessee in writing of its determination that the destruction constitutes Premises Total Destruction and Lessee may,
notwithstanding such notice, elect to preserve this Lease by delivering timely notification thereof to Lessor, given within ten (10) business days following receipt of Lessor's notice, whereby
Lessee commits to pay to Lessor any shortage in proceeds of insurance in accordance with Paragraph 9.2 or Paragraph 9.3, as applicable; provided that such preservation right shall be
subject to Lessor's right to terminate this Lease as provided in Paragraph 9.5. 

	i.)
	Paragraph 10.2—Definition of "Real Property Taxes".    Add the following at the end of
Paragraph 10.2: 

Notwithstanding
the foregoing, Real Property Taxes shall not include (a) inheritance, estate or franchise taxes imposed upon or assessed against the Premises. 

	j.)
	Paragraph 12.1(b).    Add the following at the end of Paragraph 12.1(b): 

Notwithstanding
anything to the contrary contained herein, Lessor's consent shall not be required for any of the following transfers (each of which shall be a "Permitted Transfer"): (1) to any
entity resulting from the merger, consolidation or other reorganization of Lessee, whether or not Lessee 

31

 

is
the surviving entity; or (2) to any person or legal entity which acquires all or substantially all of the assets or stock of Lessee (each of the foregoing is referred to as a "Lessee
Affiliate"), provided such Lessee Affiliate has a net worth in excess of $25,000,000.00; or (3) following Lessee's execution of a guaranty of the Lease in a form reasonably acceptable to
Lessor, to any entity which in which Lessee holds both at least 50% of the ownership interests and voting control of the entity. 

	k.)
	Paragraph 32—Lessor's Access.    Add the following at the end of Paragraph 32: 

Lessor
shall not permit such activities to unreasonably interfere with Lessee's (or any sublessee's) use of the Premises. 

	l.)
	Paragraph 34—Signs.    Add the following at the end of Paragraph 34: 

Lessee
shall not be entitled to install building and monument signs for the Premises as part of the proceeds of the Tenant Improvement Allowance. Such signs shall be installed in conformance with all
sign ordinances and regulations of all governmental agencies and the Carlsbad Research Center's CC&R's. All such signage shall be reviewed and approved by Lessor, the City of Carlsbad and the
Architectural Review Committee of the Carlsbad Research Center and permitted by the City of Carlsbad prior to manufacture and installation. Lessor's approval of signage shall not be unreasonably
withheld. 

50.    BASE RENT INCREASES:    

On
July 1, 2003, the monthly base rent shall be increased to $116,480.00 per month plus Operating Expenses;

On July 1, 2004, the monthly base rent shall be increased to $121,140.00 per month plus Operating Expenses;

On July 1, 2005, the monthly base rent shall be increased to $125,950.00 per month plus Operating Expenses;

On July 1, 2006, the monthly base rent shall be increased to $131,025.00 per month plus Operating Expenses;

On July 1, 2007, the monthly base rent shall be increased to $138,260.00 per month plus Operating Expenses;

On July 1, 2008, the monthly base rent shall be increased to $141,710.00 per month plus Operating Expenses;

On July 1, 2009, the monthly base rent shall be increased to $147,380.00 per month plus Operating Expenses;

On July 1, 2010, the monthly base rent shall be increased to $153,275.00 per month plus Operating Expenses;

On July 1, 2011, the monthly base rent shall be increased to $159,400.00 per month plus Operating Expenses; 

51.    SECURITY DEPOSIT:    

	a.
	In
lieu of a cash Security Deposit as provided in Paragraph 1.7 of this Lease, Lessee shall furnish Lessor with an Irrevocable Standby Letter of Credit ("Letter of Credit") in a
form reasonably acceptable to Lessor, terminating no earlier than 30 days beyond the expiration date of the Lease or any extension thereof, naming Blackmore Airport Centre, a California limited
partnership, as beneficiary, from an institution acceptable to Lessor (which institution shall be acceptable to Lessor if it is a bank of the size and quality of Bank of America, Wells Fargo,
Citibank, Union Bank of California, US Bank or similar "money center" banks) in the original amount of $1,350,000 to be used by Lessor to secure Lessee's faithful performance of all terms, provisions
and conditions of this Lease. Lessee shall furnish the Letter of Credit to Lessor within five (5) business days of the execution of this Lease. If during the course of this Lease or any
extension 

32

 

thereof,
Lessor is notified by the bank issuing said Letter of Credit that it will not be renewed, then such notification shall constitute a Default and material breach of this Lease and allow Lessor
to draw upon such Letter of Credit, unless fifteen (15) days prior to the expiration of such Letter of Credit, Lessee delivers to Lessor another Letter of Credit in the required amount by an
institution and in form reasonably approved by Lessor. Upon any Default under the Lease (after expiration of the applicable cure periods defined in Paragraph 13), Lessor shall be permitted to
draw upon the Letter of Credit and use the proceeds of the Letter of Credit as provided in Paragraph 5 of the Lease. Upon the cure of Lessee's Default resulting in a draw upon the Letter of
Credit, as long as Lessee is not in default under the Lease, Lessee shall have the right to replace the cash security deposit held by Lessor with a new letter of credit which meets the criteria of the
Letter of Credit under this Paragraph 51. 

If
Lessor draws upon the Letter of Credit, Lessor shall hold any amounts not used to cure Lessee's Default under the Lease as a cash Security Deposit and Lessee shall have the obligation to deposit
additional cash with Lessor so that the cash Security Deposit is at least equal to the amount of the Letter of Credit that Lessee would otherwise be required to maintain pursuant to the provisions
below. 

	b.
	Lessor
and Lessee acknowledge that the amount of the Letter of Credit may fluctuate during the Term of the Lease. On or before the 20th day of every month of the Lease
Term, Lessee shall provide the Lessor (x) a financial statement for the immediately preceding month certified as true, complete and correct by the CFO of Lessee that includes an accurate cash
balance of the Lessee and (y) supporting bank statements also certified by the CFO to be true, complete and correct (such statements as of a date no earlier than the last day of the immediately
preceding month) which indicate the balance of cash held by the Lessor in such institution(s) as of that date. Lessor shall be required to maintain the following amount of Letter of Credit based on
the amount of cash shown on the certified financial statements and certified bank statements:

	1.
	If
the cash balance is less than $5,000,000, then Lessee shall deliver to Lessor with the financial statements and bank statements a replacement Letter of Credit in the amount of
$1,900,000;

	2.
	If
the cash balance is between $5,000,000 and $50,000,000, then the amount of the Letter of Credit shall be $1,350,000 and if Lessor was at that time holding a Letter of Credit in the
amount of $350,000, then Lessee shall deliver to Lessor together with the financial statements and bank statements a replacement Letter of Credit in the amount of $1,350,000; and

	3.
	If
the cash balance is greater than $50,000,000, then the amount of the Letter of Credit shall be reduced to $350,000. 

If
the amount of the Letter of Credit at the time of delivery of the financial statements and bank statements is to be modified, then Lessor shall cooperate in returning the Letter of Credit it then
holds as soon as it receives the replacement Letter of Credit in the modified amount. 

52.    OPERATING EXPENSES:    Notwithstanding anything to the contrary contained herein, in addition to the monthly base rent,
Lessee shall reimburse Lessor for the following: 

	a)
	Property Taxes: Estimated to be $116,667.00 per year;

	b)
	Property Insurance: Estimated to be $7,800.00 per year;

	c)
	Landscape Maintenance: Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, it is understood by the
parties hereto that Lessor shall maintain the landscaping for the Building at Lessee's expense. Lessor shall employ a landscaping contractor to maintain the landscaping to include fertilizing,
changing of annual colored flowers at entrance, tree trimming and replacing of dead plants for the Building, and Lessee shall reimburse Lessor 

33

 

monthly
in addition to rent for such maintenance. Such maintenance is estimated to be $6,300.00 per year, subject to increase. 

CRC Common Area Maintenance Fees:    Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, it is
understood by the parties hereto that there exists a monthly common area maintenance fee changed by Carlsbad Research Center (CRC). Said maintenance for the Building is currently $4,850.00 per year,
subject to increase. 

	d)
	HVAC Maintenance: Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, Lessor shall procure and
maintain, at Lessee's expense, an air conditioning system maintenance contract, providing for quarterly service. Such maintenance is estimated to be $10,000.00 per year, subject to increase.

	e)
	Water: Lessee acknowledges that the Building is equipped with three (3) water meters (Building, Landscape and Fire Sprinkler).
Lessor shall maintain the three water meter accounts in its name and Lessee shall reimburse Lessor for the cost thereof.

	f)
	Fire Sprinkler Maintenance/Monitoring: Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, it is
understood by the parties hereto that the Building is equipped with a fire sprinkler alarm system for which Lessee shall be responsible. Upon substantial completion of the tenant improvements, the
contract with ADT Security shall be transferred into Cancer Vax's name. The current cost of the basic service is estimated to be $800.00 per year. Lessor shall have no liability to Lessee with respect
to the fire sprinkler maintenance and monitoring equipment.

	g)
	Fire Sprinkler Testing and Certification: It is understood by the parties hereto that the building is equipped with an automatic fire
sprinkler system, which according to state law, must be serviced and inspected quarterly and certified every five (5) years. Notwithstanding anything to the contrary contained in
Paragraph 7 of this lease, Lessor shall procure and maintain a fire sprinkler maintenance contract providing for the required quarterly inspections and service and five (5) year
certifications. Annual fire sprinkler testing is estimated to be $900.00 per year, subject to increase. Lessee shall reimburse Lessor for these services.

	h)
	Roof Inspections: Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, Lessor shall procure and
maintain, at Lessee's expense, a roof inspection contract, providing for bi-annual inspections of the roof. Such inspection is currently $75.00 per inspection, subject to increase.

	i)
	Exposed Aggregate Concrete Sealer Maintenance: It is understood by the parties hereto that the exposed aggregate paving areas located at
the front entrance and side walkways of the Premises have been treated with a clear concrete sealer. Said sealer must be reapplied a minimum of two times per year, or as needed, in order to protect
these areas from automobile oils and deterioration. Notwithstanding anything to the contrary contained in Paragraph 7 of this Lease, Lessor shall use its good faith efforts to determine when it
is appropriate to have the sealer reapplied to these areas and Lessee shall reimburse Lessor upon demand for these costs. It is estimated that the cost to install the sealer will be $3,000.00 per
year, subject to increase.

	j)
	Fossil Filter Maintenance: The on-site storm drain system is equipped with one or more 6" continuous Storm Water
Filtration System ("SWFS") to effectively prohibit non-storm water discharges into the storm sewer. Notwithstanding anything to the contrary continued in Paragraph 7 of this Lease,
Lessor shall procure and maintain, at Lessee's expense, a preventative maintenance contract to inspect, service and maintain the fossil filter three (3) times per year. The cost of this service
is estimated to be $200.00 per year per SWFS, subject to increase. 

34

 
	k)
	Backflow Maintenance: Each water meter is equipped with a blackflow maintenance device that must be tested annually to prevent any water
from flowing back into the public water supply. The annual backflow maintenance testing is currently $300.00, subject to increase.

	l)
	Window Washing: It is understood by the parties hereto that Lessor shall procure and maintain a contract providing for interior and
exterior window washing on a quarterly basis and Lessee shall reimburse Lessor monthly in addition to rent for such maintenance. Such maintenance is estimated to be $2,800.00 per year, subject to
increase.

	m)
	Elevator Maintenance: It is understood by the parties hereto that if Lessee elects to install an elevator to service the Building as
part of its Tenant improvements, said elevator must be inspected, serviced and adjusted monthly in accordance with the manufacturer's specifications. The estimated cost for the inspections, excluding
repairs, is $1,800.00 per year, subject to increase. 

The
initial annual budget cap for the Operating Expenses shall be determined prior to the commencement date of the lease. If at any time during the term of the Lease, the Operating Expenses exceed the
budget cap (which budget cap shall increase by 4% each year), then Lessee shall have the
option, but not the obligation, to propose to Lessor different lower cost vendors to perform the services listed in 52 c, e, g, h, j, k, m and n above. If Lessor approves a vendor proposed by Lessee
(such approval not be unreasonably withheld), then Lessor shall contract with the vendor proposed by Lessee to perform such services. 

53.    REASONABLE EXPENDITURES:    Any expenditure by a party permitted or required under the Lease, for which such party is
entitled to demand and does demand reimbursement from the other party, shall be limited to the fair market value of the goods and services involved, shall be reasonably incurred and shall be
substantiated by documentary evidence available for inspection and review by the other party or its representatives by appointment during normal business hours. 

54.    YEAR END OPERATING EXPENSE RECONCILIATION:    The adjustments to the annual Operating expenses amount shall be made in
accordance with the following procedures: 

        (i)    On
or before December 15 of each Calendar Year, Lessor shall endeavor to provide Lessee notice of its reasonable estimate of the amounts payable under this Lease
for the ensuing Calendar year. 

        (ii)   As
soon as reasonably possible following the close of each Calendar Year of this Lease, Lessor shall deliver to Lessee a statement reconciling Lessee's estimated
monthly operating budget payments with the actual operating expenses for the preceding Calendar Year. Lessor shall include in this statement a reasonably detailed description of the Operating
Expenses. If, on the basis of such statement, Lessee owes an amount that is less than the estimated payments for such Calendar Year previously made by Lessee, Lessor shall credit such excess to
Lessee's next monthly payment of Rent or, if applicable, Extended Term Rent. If no further Rent is due or payable under this Lease, Lessor shall refund such excess to Lessee along with its delivery of
such statement. The Lessor's obligations under this Paragraph 54 shall survive the expiration of this Lease. If, on the basis of such statement, Lessee owes an amount that is more than the
estimated payments for such Calendar Year previously made by Lessee, Lessee shall pay the deficiency to Lessor within ten (10) days after delivery of the statement. 

        (iii)  With
respect to any Operating Expenses incurred by Lessor on behalf of Lessee that are not included in the estimate Lessor provides to Lessee on or before
December 1 of each Calendar Year, including, without limitation, non-recurring repair expenses, Lessor shall provide notice to Lessee of such additional Operating Expenses and
Lessee shall reimburse such expenses to Lessor within ten (10) days of its receipt of such notice. 

35

 

55.    PARKING:    Lessee shall have the exclusive use of the parking lot on the Premises, which lot shall have a minimum of
two-hundred (210) on site parking spaces. Said parking areas of the Premises shall be used only for parking of automobiles, and the loading and unloading of trucks. The use by
Lessee of those areas for storage of materials (including pallets) is expressly prohibited. All material shall be stored within the freestanding main building. 

56.    ROOF MAINTENANCE:    Lessee shall not take any action to cause the GAF Materials Corporation Liberty
Guarantee attached hereto and made a part hereof as Exhibit E of the Lease to become ineffective including, without limitation, those actions described in
items 5-8 in the "Exclusions From Coverage" in such guarantee. 

57.    ROOFTOP RIGHTS:    Subject to the provisions of Paragraph 56, after receipt of approval by Lessor, and in compliance
with all applicable laws, regulations and Carlsbad Research Center CC&R's, Lessee shall have the right, at Lessee's sole cost, to reasonably access and use the building's (i) roof to install,
repair and maintain upon the building's roof, telecommunication devices, such as satellite dishes and antennae or other similar devices, for the purpose of receiving and sending radio, television,
computer, telephone or other communications signals and (ii) internal passageways, shafts, utility connections, risers and conduits in order to connect such telecommunication devices to the
Premises. Tenant will be responsible for any damage to the building caused by installing or removing such devices including, if necessary replacement of the roof. 

58.    LIEN WAIVER:    Lessor acknowledges Lessee's right to finance and to secure under the Uniform Commercial Code, inventory,
furnishings, furniture, equipment, machinery, leasehold improvements and other personal property located in or at the Premises, and Lessor agrees, upon Lessee's request, to execute the waiver forms
attached hereto as Exhibit G releasing liens in favor of any purchase money seller, lessor or lender who has financed or may finance in the future such items. Without limiting the effectiveness
of the foregoing, provided that no default shall have occurred and be continuing, Lessor shall, upon the request of Lessee, and at the Lessee's sole cost and expense (including Lessor's reasonable
attorney fees incurred in relation thereto), execute and deliver any commercially reasonable instruments necessary or appropriate to confirm any such grant, release, dedication, transfer, annexation
or amendment to any person or entity permitted under this paragraph including Lessor waivers with respect to any of the foregoing. 

59.    BIOHAZARD WASTE STORAGE:    Lessee shall have the right to install and operate, in accordance with all applicable laws, a
biohazard waste disposal bin for Lessee's exclusive use on the Premises, for the temporary storage of biohazardous waste. Notwithstanding anything to the contrary contained in the Lease, Lessee shall
be responsible for all fees and costs (including, without limitation, licensing and permitting fees) of keeping such units in good order, condition and repair (including, without limitation, repairing
and maintaining all safety and security systems associated with such disposal bin) in accordance with all applicable laws. Lessee shall provide Lessor with copies of all reports and applications
related to such disposal bin simultaneously with submission. At the earlier of the termination of the Lease or Lessee's termination of its such biohazardous waste disposal bin, Lessee will retain a
qualified environmental consultant, at its sole cost, who is acceptable to Lessor, to perform and exit assessment of those portions of the Common Areas: (a) where the biohazard waste disposal
bin was located prior to its removal, and (b) over which the path of access between the Premises and the units was located and will remedy, at Lessee's sole cost and expense, all items
identified in such assessment. 

60.    GENERATOR RIGHTS:    Subject to Lessor's approval as to the location and plans and specifications for the design, operation,
installation and maintenance therefore, Lessee may, install an emergency backup diesel-powered generator on the Premises. Lessor may require as a condition of installation of the emergency generator
that Lessee install such protective modifications as Lessor reasonably deems necessary to prevent or contain any release or spill of Hazardous Materials, and 

36

 

Lessee
shall ensure that the backup generator dose not result in any Hazardous Materials being released to the Premises. Lessee shall install, repair, maintain and operate the backup generator at its
sole cost and expense in a good workmanlike manner in accordance with all applicable laws. Prior to commencement of installation of the backup generator, Lessee shall obtain and provide Lessor with
copies of all permits and other government approvals required for installation and operation of the backup generator, which shall be obtained by Lessee at its sole cost and expense. 

61.    ENTRANCE/EXIT ASSESSMENTS:    

        (a)    Entrance Assessment.    No earlier than 30 days prior to substantial completion of the Tenant
Improvements, but prior to the Commencement Date, Lessor shall conduct an "Entrance Assessment," consisting of a Phase I Environmental Assessment and such other tests as may be necessary including the
following studies and assessments: 

	A.
	Phase I
Environment Assessment.

	B.
	The
following additional assessments, inspections and monitoring plans: 

        1.     Interior
Site Assessment consisting of a visual inspection of all bench and hood sinks and readily accessible drain lines provided as part of the Tenant Improvements for
signs of loss of integrity and leakage. The Interior Site Assessment shall include detailed written documentation of all observations and dated photos to document the existing condition thereof. 

        2.     Wastewater
Collection System Assessment consisting of a flush and clean-out of all discharge piping and traps with observation of effluent during the
clean-out. Videotaping of the Wastewater Collection System shall be required if the flush is observed to contain constituents which could indicate a break in said System. 

        3.     Laboratory
Hoods and Exhaust System Inspection consisting of an inspection of the laboratory hoods and exhaust system provided as part of the Tenant Improvements for
signs of loss of integrity and leakage. Such inspection shall include inspection of the roof area. 

        4.     Sampling
and Analysis Plan to be developed if the consultant, based on the foregoing assessments and the Phase I Environmental Assessment performed pursuant to
this Entrance Assessment recommends further sampling and analysis. Any such Sampling and Analysis Plan, and the results thereof, shall be included in the Exit Assessment. 

Lessee
shall receive a copy of the report(s) of the Lessor's Entrance Assessment, and said report(s) shall be deemed to be the baseline physical condition of the Premises upon Lessee's occupancy. The
cost of the Phase I portion of the Lessor's Entrance Assessment shall be paid by Lessor and the remainder, including items B 1-4 shall be paid for by Lessee. The
Entrance Assessment shall be performed by an independent laboratory and consultant with expertise in performing environmental analyses of biotechnology laboratory facilities. 

        (b)    Exit Assessment.    No earlier than 30 days prior to the expiration or earlier termination of the Lease,
but prior to Lessee's surrender of the Premises to Lessor, Lessee shall conduct an "Exit Assessment," consisting of a Phase I Environmental Assessment and such other tests as may be necessary
including the following studies and assessments: 

	A.
	Phase I
Environmental Assessment.

	B.
	The
following additional assessments, inspections and monitoring plans: 

        1.     Interior
Site Assessment consisting of a visual inspection of all surfaces (floors, walls, ceiling tiles, benches, interior of cabinets and fume hoods) for signs of
contamination and deterioration. Visual inspection of all bench and hood sinks and readily accessible drain lines for signs of deterioration, loss of integrity and leakage. The Interior Site
Assessment shall include 

37

 

detailed
written documentation of all observations and dated photos to document the existing condition thereof. 

        2.     Wastewater
Collection System Assessment consisting of a flush and clean-out of all discharge piping and traps with operation of effluent during the
clean-out. Videotaping of the Wastewater Collection System shall be required if the flush is observed to contain constituents which could indicate a break in said System. 

        3.     Laboratory
Hoods and Exhaust System Inspection consisting of an inspection of the laboratory hoods and exhaust system with detailed documentation of all observances,
including without limitation, observed solids, liquids, odors or Hazardous Materials entrapment. Such inspection shall include inspection of the roof area to determine the existence of any
deterioration from condensation of hazardous materials in the exhaust system. Recommendations are to be developed for further sampling based upon a visual observation of stacks, exhaust fans and the
roof. 

        Lessor
shall receive a copy of the report(s) of the Lessee's Exit Assessment, and said report(s) shall be deemed to be the baseline physical condition of the Premises upon Lessee's
surrender of the Premises. The cost of the Lessee's Exit Assessment and all costs associated with restoring the Premises to its condition recommended by the consultant conducting the Exit Assessment
shall be paid by Lessee. The Exit Assessment shall be performed by an independent laboratory and consultant, acceptable to Lessor and Lessor's Lender, with expertise in performing environmental
analyses of biotechnology laboratory facilities. 

62.    OPTION TO EXTEND:    Provided that Lessee is not then in default under any of the terms, covenants and conditions of the
Lease, Lessor hereby grants to Lessee, subject to the conditions hereinafter set forth, two (2), five (5) year options to extend the term of this Lease. These options shall be exclusive to
CancerVax Corporation or its Lessee Affiliates but not to assignees or subtenants. Provided that as long as CancerVax is occupying at least 25,000 square feet of the premises at the time it exercises
such options, Lessee shall be permitted to similarly extend any or all subleases of the Premises for all or a portion of the extended term of this Lease. The option shall be on such terms and
conditions as this Lease, except for Base Rent, which shall be adjusted as set forth below. This grant of an option shall be of no force and effect unless Lessee gives Lessor written notification of
Lessee's intent to exercise the option by at least January 1, 2012 and not sooner than October 1, 2011. 

63.    BASE RENT INCREASES DURING OPTION PERIOD:    July 1, 2012, and if the first option is exercised, again on
July 1, 2017, the monthly base rent due hereunder shall be increased to the fair market rental value of the Premises as of January 1, 2012 and January 1, 2017, respectively.
Lessor shall determine fair market rental value by using its best good faith judgement. As used herein "fair market rental value" shall mean the projected prevailing rental rate as of
January 1, 2012 and January 1, 2017 respectively for generally similar sized and improved R&D space (but without consideration for Trade Fixtures and Equipment purchased by Lessee and
included on the Equipment List compiled by Lessee and acknowledged by Lessor prior to installation) situated in the area of Carlsbad, California, but not taking into account prevailing rental
concessions, tenant improvement allowances and any other concessions offered for such similar space as of such date. Lessor shall use its best efforts to provide written notice of such amount not
later then three (3) months prior to the expiration of the original lease term. Lessee shall thereafter have fifteen (15) days ("Lessee's Review Period") after receipt of Lessor's notice
of the fair market rental value within which to accept such fair market rental value or to reasonably object thereto in writing. 

In
the event Lessee objects to the fair market rental value submitted by Lessor, Lessor and Lessee shall attempt in good faith to agree upon such fair market rental value, using their best good faith
efforts. If Lessor and Lessee fail to reach agreement on such fair market rental value within fifteen (15) days following Lessee's Review Period (the "Outside Agreement Date"), then the
determination of 

38

 

fair
market rental value shall be submitted to arbitration under the provisions of the American Arbitration Association. The cost of arbitration shall be paid by Lessor and Lessee equally. 

During
the remainder of each option term, the monthly base rent shall be increased annually on July 1 of each year by one hundred and four percent (104%) times the rent in effect immediately
preceding the date of the rent adjustment. 

"NOTICE:
BY INITIALING THE SPACE BELOW YOU ARE AGREEING TO HAVE ANY DISPUTE ARISING OUT OF THE MATTERS INCLUDED IN THE "ARBITRATION OF DISPUTES" PROVISION CONTAINED IN THIS PARAGRAPH 63 OF THIS
ADDENDUM
DECIDED BY NEUTRAL BINDING ARBITRATION BEFORE A SINGLE ARBITRATOR AS PROVIDED BY CALIFORNIA LAW AND YOU ARE GIVING UP ANY RIGHTS YOU MAY POSSESS TO HAVE THE DISPUTE LITIGATED IN A COURT OR JURY TRIAL.
BY INITIALING IN THE SPACE BELOW YOU ARE GIVING UP YOUR JUDICIAL RIGHTS TO DISCOVERY AND APPEAL, UNLESS SUCH RIGHTS ARE SPECIFICALLY INCLUDED IN THE "ARBITRATION OF DISPUTES" PROVISION. IF YOU REFUSE
TO SUBMIT TO ARBITRATION AFTER AGREEING TO THIS PROVISION, YOU MAY BE COMPELLED TO ARBITRATE UNDER THE AUTHORITY OF THE CALIFORNIA CODE OF CIVIL PROCEDURE. YOUR AGREEMENT TO THIS ARBITRATION PROVISION
IS VOLUNTARY." "WE HAVE READ AND UNDERSTAND THE FOREGOING AND AGREE TO SUBMIT DISPUTES ARISING OUT OF THE MATTERS INCLUDED IN THE "ARBITRATION OF DISPUTES" PROVISION TO NEUTRAL BINDING ARBITRATION." 

	"Lessor"	 	"Lessee"
	/s/ AJB
 Initials	 	/s/ DFH
 Initials

64.    EXHIBITS:    The following exhibits are attached hereto and made a part hereof: 

Exhibit A—"For
Construction" Shell Building Plans;

Exhibit B—Tenant Improvement Agreement;

Exhibit C—Proposed Lessor Designed Tenant Improvement Space Plans;

Exhibit D—Site Plan;

Exhibit E—Roof Guarantee;

39

 

Exhibit F—Condition
of Building Upon Possession.

Exhibit G—Landlord Waiver and Consent Form. 

	LESSOR:	 	LESSEE:
	

BLACKMORE AIRPORT CENTRE,

A CALIFORNIA LIMITED PARTNERSHIP	
 	

CANCERVAX CORPORATION
	

By:	
 	

Blackmore Family Partners,

A California General Partnership,

General Partner	
 	

 	
 	

 
	

By:	
 	

/s/  ALLEN JOSEPH BLACKMORE      
 Allen Joseph Blackmore, Trustee

of the Blackmore Family Trust

Restated 1995, General Partner	
 	

By:	
 	

/s/  DAVID F. HALE      
 David F. Hale,

President and CEO
	

Date:	
 	

September 19, 2001
	
 	

Date:	
 	

September 19, 2001

	

 	
 	

 	
 	

By:	
 	

/s/  WILLIAM R. LARUE      
 William R. LaRue,

Vice President and CFO
	

 	
 	

 	
 	

Date:	
 	

September 19, 2001

40

  

 
 

EXHIBIT A
  
    "FOR CONSTRUCTION" SHELL BUILDING PLANS
  DELIVERED TO CANCER VAX
  ON AUGUST 31, 2001    
    

41

 
 
 

EXHIBIT "B"
  
    TENANT IMPROVEMENT AGREEMENT    
    

        This Tenant Improvement Agreement ("Agreement") is entered into as of August 31, 2001 between Blackmore Airport Centre, a California limited partnership
("Lessor") and CancerVax Corporation, a Delaware corporation ("Lessee"), in connection with the execution of the Lease between Lessor and Lessee executed simultaneously with this Agreement ("Lease"),
who agree as follows: 

1.    General.    

	a.
	The
purpose of this Agreement is to set forth how the interior improvements in the Premises, including additional mezzanine space, offices, employee services facilities, restroom
facilities, laboratory facilities and warehouse areas ("Tenant Improvements") are to be constructed, who will perform the construction of the Tenant Improvements and who will pay for the construction
of the Tenant Improvements.

	b.
	Lessor
has commenced construction of the shell of the premises ("Shell") in accordance with those certain architectural drawings prepared by Smith Consulting Architects ("SCA") dated
February 22, 1997 (the "Shell Architectural Drawings"), which shall be a "cold" shell and Lessee has approved and accepted the Shell Architectural Drawings. Lessor shall proceed to complete the
construction of the Shell within a commercially reasonable period in accordance with the Shell Architectural Drawings. Lessor shall be responsible for the costs of construction of the Shell, but any
improvements requested by Tenant which are not contained in the Shell Architectural Drawings as of August 10, 2001, shall be considered part of the Tenant Improvements (including any
modifications made to the Shell to the extent necessary to accommodate the Tenant Improvements).

	c.
	Lessee
has requested that Lessor expand the Shell, the cost of which shall be deducted from the Allowance (as defined below). These improvements ("Mezzanine Improvements") shall
consist of adding approximately 5,400 square feet of mezzanine space to the Shell. SCA or another architect selected by Lessor shall prepare the Mezzanine Improvements plans, which, if approved by
Lessee, shall be attached to the Shell Architectural Drawings, and Reno Contracting, Inc. shall construct the Mezzanine Improvements.

	d.
	The
parties anticipate that after completion of the Mezzanine Improvements, the Tenant Improvements may be installed in two phases. The improvement of approximately 30,400 square feet
of office area and approximately 25,000 square feet of laboratory space in the Premises shall constitute the first phase of the remaining Tenant Improvements ("Phase 1"). If Tenant so elects,
Tenant may, without obligation to do so, install the second phase of the Tenant Improvements, consisting of a pilot manufacturing facility ("Phase 2"), following completion of the
Phase 1 portion of the Tenant Improvements. However, Lessee may elect to have the Phase 1 and Phase 2 portions of the Tenant Improvements constructed simultaneously.

	e.
	Except
as defined in this Agreement to the contrary, all terms utilized in this Agreement shall have the same meaning as the defined terms in the Lease.

	f.
	The
provisions of the Lease, except where clearly inconsistent or inapplicable to this Agreement, are incorporated into this Agreement. 

42

 

2.    Designer/Architect.    The plans for Phase 1 of Tenant Improvements shall be prepared by McGraw/Baldwin Architects or
such other architect approved by Lessor and Lessee ("Designer") who is familiar with all applicable laws, statutes, codes, rules and regulations applicable to construction of Phase 1 of the
Tenant Improvements (collectively "Laws"). The plans for Phase 2 of Tenant Improvements, if Tenant elects to install such additional Tenant Improvements, may be prepared by either the Designer,
or such other designer as may be approved by Lessor (which approval shall not be unreasonably withheld) who is familiar with all Laws applicable to construction of Phase 2 of the Tenant
Improvements. The cost of the space planning, architectural and engineering services (including "value engineering" services) relating to the preparation of the plans for the Phase 1 and
Phase 2 Tenant Improvements shall be included in the cost the Tenant Improvements. 

3.    Preparation of Plans and Construction Schedule for Tenant Improvements.    Lessor shall (A) contract with the Designer
(with Lessee named as third party beneficiary in such contract) to design the Phase 1 Tenant Improvements and, if Lessee so requests, contract with Designer or such other designer approved by
Lessor to design the Phase 2 Tenant Improvements (each, a "Design Contract"), (B) provide instructions and the Shell Architectural Drawings to the Designer to complete the plans and
specifications, (C) contract (with Lessee named as Owner in the contract for construction of the Tenant Improvements) for the construction of Phase 1 and, if Lessee so requests,
Phase 2 of the Tenant Improvements and (D) supervise the Contractor in the construction of the Tenant Improvements: 

	a.
	Lessee
shall provide Designer with sufficient information to allow Designer to prepare preliminary schematic layouts for the Phase 1 Tenant Improvements. Immediately after
Lessor and Lessee have approved the preliminary schematic layout for the Phase 1 Tenant Improvements, Designer shall be directed to prepare Working Drawings for Phase 1 ("Phase 1
Working Drawings") which shall be delivered to Lessor and Lessee. Lessee recognizes that Lessor is providing the Allowance in the expectation that the office portion of the Tenant Improvements will be
useable by the type of tenant that usually occupies buildings in the Carlsbad Research Center. Consequently the quality of the Tenant Improvements (in terms of design and materials) shall be no less
than the quality of the office portion of the tenant improvements contained in those buildings developed by entities controlled by Allen Blackmore in the Carlsbad Research Center. Lessor and Lessee
shall cooperate to reduce the costs of the Tenant Improvements as reasonably requested by Lessee, but not below the standard of quality provided herein. Lessee may select different materials of equal
or greater value in place of Lessor's standard building materials provided such selection is indicated on the Plans. The Working Drawings may be submitted in one or more stages.

	b.
	Lessee
shall approve such Phase 1 Working Drawings or designate by notice to Lessor the specific changes required to be made to the Phase 1 Working Drawings, which Lessor
shall direct to Designer as soon as reasonably possible. Upon receipt of Lessee's approval of the Phase 1 Working Drawings, Lessor shall cause the Designer to submit them to the appropriate
municipal authorities and design review boards of the Carlsbad Research Center for all applicable building permits and approvals necessary to allow Contractor to commence and fully complete the
construction of the Phase 1 Tenant Improvements. Lessor shall be responsible for obtaining any building permit or certificate of occupancy for the Premises; provided that Lessee shall cooperate
with Lessor in executing permit applications and performing other ministerial acts reasonably necessary to enable Lessor to obtain any such permit or certificate of occupancy. 

43

 

	c.
	After
Lessee has approved the Phase 1 Working Drawings, Lessor shall cause the Designer to submit to Lessee final Phase 1 plans ("Phase 1 Plans") which shall be
defined as, and shall consist of, complete architectural plans (inclusive of Working Drawings) and specifications necessary to allow the Contractor to build the Phase 1 Tenant Improvements in
accordance with the final Phase 1 Plans. The term "Phase 1 Tenant Improvements" shall mean all improvements shown on the final Phase 1 Plans as finally approved by Lessee.

	d.
	Lessee
shall approve such Phase 1 Plans or designated by notice to Lessor the specific changes required to be made to such Phase 1 Plans, which Lessor shall direct to
Designer as soon as reasonably possible. No changes, modifications or alterations in the Phase 1 Plans approved by Lessee and Lessor may be made without the prior written consent of both Lessee
and Lessor, which shall not be unreasonably withheld, conditioned or delayed.

	e.
	After
Lessee's approval of the Phase 1 Plans, Lessor shall submit to Lessee a detailed written estimate of the Total Costs of the Tenant Improvements covered by the
Phase 1 Plans ("Work Cost Estimate"). Lessee shall approve the Work Cost Estimate or designate by notice the specific portions of the Work Cost Estimate which Lessee disapproves or desires
"value engineering" services to be performed to reduce the cost thereof. If Lessee reasonably disapproves all or any portion of the Work Cost Estimate, or requests value engineering services to be
performed, the parties shall immediately meet in order to revise the Work Cost Estimate to an amount which is acceptable to Lessee, but shall maintain the quality of Tenant Improvements described
above in any such revisions.

	f.
	Once
the Phase 1 Plans have been approved, Lessee shall provide Designer with sufficient information to allow Designer to prepare a schematic layout of the Phase 2 Tenant
Improvements. Lessor and Lessee recognize and agree that Lessee may elect to delay or forego the design and construction of the Phase 2 Tenant Improvements for an undetermined period of time
after the Substantial Completion of the Phase 1 Tenant Improvements. After Lessor and Lessee have approved the preliminary schematic layout, Designer shall be directed to prepare Working
Drawings for Phase 2 ("Phase 2 Working Drawings") which shall be delivered to Lessor and Lessee. The Phase 2 Working Drawings and the Phase 2 Plans shall be approved
according to the same procedures as the Phase 1 Working Drawings and Phase 1 Plans as described in subparagraphs 3 b-e above.

	g.
	The
Phase 1 Working Drawings and the Phase 2 Working Drawings are sometimes collectively referred to herein as the "Working Drawings." Similarly, the Phase 1 Plans
and the Phase 2 Plans are sometimes collectively referred to herein as the "Plans" and the Phase 1 Tenant Improvements and the Phase 2 Tenant Improvements are sometimes
collectively referred to herein as the "Tenant Improvements." 

4.    Construction of Tenant Improvements.    

	a.
	Lessor
shall make arrangements for Reno Contracting, Inc. or such other contractor selected by Lessor ("Contractor") to construct the Phase 1 Tenant Improvements as
indicated on the Phase 1 Plans in a good and workmanlike manner as soon as reasonably possible and consistent with industry custom and practice. Although Lessor will enforce the contract with
Contractor to have the Tenant Improvements completed as soon as reasonably possible, Lessor shall not be liable for delay in the construction of the Tenant Improvements except to the extent that such
delay is caused by Lessor's failure to respond to Working Drawings or Plans within three business days of their submission to Lessor and such delay directly causes a delay in the Substantial
Completion of the proposed Tenant Improvements. 

44

 

	b.
	The
construction contract for the Phase 1 Tenant Improvements with Contractor (the "Construction Contract") shall be in form and substance acceptable to Lessor and reasonably
approved by Lessee and shall include, without limitation, requirements (i) that Contractor carry such insurance as Lessor and Lessee may reasonably require, (ii) that the Contractor
provide a commercially reasonable construction warranty, which may be enforced by Lessee, (iii) that the Contractor's fee shall be calculated on a "cost plus a fee" basis where the fee for
overhead and profit shall not exceed five percent (5%) of cost and the fee for liability insurance shall not exceed .60% (with the amount charged for general conditions and supervision competitive
with the current market for similar tenant improvement projects in the Carlsbad Research Center, and (iv) that Contractor secure independent sealed bids from three (3) subcontractors
mutually acceptable to Lessor and Lessee (to the extent that such bids are reasonably available) for each trade (except for roofing and fire safety, which subcontractors Lessor shall select) whose
costs are in excess of five percent (5%) of the Work Cost Estimate. Lessee may designate that the lowest bidding subcontractor be selected. Both Lessor and Lessee shall have the full benefit of all
contractor warranties in connection with the Phase 1 Tenant Improvements. Lessor shall direct and authorize Contractor to keep Lessee's representative fully informed of the construction process
for the Phase 1 Tenant Improvements and to provide Lessee's representative with access to all documentation and other information in Contractor's possession or control regarding construction of
the Phase 1 Tenant Improvements. The Construction Contract shall not require the Contractor to post a completion bond if the premium therefor will be included in the Total Cost without the
Lessee's express prior written consent.

	c.
	If
Lessor and Lessee elect to construct the Tenant Improvements in two phases, then following the issuance of a certificate of occupancy for the Phase 1 Tenant Improvements and
Lessee's deposit of the amount by which the Total Cost exceeds the remaining Allowance as described in paragraph 5 below, Lessor shall make arrangements for Contractor to construct the
Phase 2 Tenant Improvements. Lessor and Lessee shall cooperate with Contractor and Designer to cause the Phase 2 Tenant Improvements to be completed as soon as reasonably possible after
the completion and approval of the Phase 2 Working Drawings as described in Section 3.e above.

	d.
	Lessee
shall designate a representative who shall attend all planning and construction meetings related to the Tenant Improvements. Lessor shall designate a representative to
participate in the Tenant Improvement process. However, Lessor shall not receive a separate fee in connection with Lessor's reviewing the design and construction of the Tenant Improvements for the
Premises and supervising Contractor in the construction of the Tenant Improvements.

	e.
	Lessor
shall complete construction of the Shell within a commercially reasonable period in accordance with the Shell Architectural Drawings. However, if Lessor delays completion of the
Shell (other than delays related to the Mezzanine Improvements or other changes requested by Lessee) and such delay causes a corresponding delay in the completion of the Tenant Improvements, then the
Commencement Date shall be pushed forward by the number of days in delay of the completion of the Shell that caused a corresponding delay in the completion of the Tenant Improvements.

	f.
	Prior
to execution of the contracts with the Designer and the Contractor, Lessor and Lessee shall agree upon a schedule for design and construction of the Tenant Improvements
("Completion Schedule"), broken down by number of days to complete certain milestones and attach it to this Agreement as Schedule I. If either Designer or Contractor fall behind more than
fourteen (14) days in the completion of any milestone in the Completion Schedule, then Lessee may 

45

 

provide
Lessor with a notice that the Completion Schedule is not being met. Lessor shall use commercially reasonable efforts to cause Designer or Contractor, as the case may be, to remedy the
failure to proceed pursuant to the Construction Schedule. If within five (5) business days after receipt of such notice Lessor is unable to cause Designer or Contractor, as the case may be, to
provide reasonably acceptable assurances that there will be no further delay in the identified portion of the Completion Schedule or that the identified delay otherwise will be remedied and the other
portions of the Completion Schedule will be met, then Lessee shall have the right to enforce its third party beneficiary rights under the contract with the Designer or Contractor, as applicable, and
take any action Lessee deems reasonably necessary to cause completion of the Tenant Improvements as soon as reasonably possibly, including, without limitation, termination of the applicable contract
with Designer or Contractor. Notwithstanding the foregoing, any action Lessee may take pursuant to this subparagraph 4.f shall be deemed a Change Order for purposes of this Agreement and Lessee
shall comply with the provisions of Paragraph 7 of this Agreement with respect to any action that Lessee may take that increases the cost of completing the Tenant Improvements, including,
without limitation, the cost of terminating any contracts. Lessor shall have no liability with respect to any delays in completion of the Tenant Improvements in connection with such circumstances. 

5.    Tenant Improvement Allowance.    The planning and construction of the Mezzanine Improvements and the Tenant Improvements shall
be at Lessee's sole and entire cost except for the Allowance. Lessor will provide a tenant improvement allowance of $4,300,000 ("Allowance") toward the cost of the design and construction of the
Mezzanine Improvements and the Tenant Improvements ("Total Cost"). The Total Cost shall include all direct and indirect costs and expenses incurred by Lessor relating to the Mezzanine Improvements and
the Tenant Improvements as indicated by the Plans and the Work Cost Estimate, as modified, including, without limitation, all direct and indirect costs related to the architectural, engineering and
inspection fees, the costs of the Working Drawings and the Plans, payments made under all construction contracts, premiums for all bonds and insurance, all sales, use or similar taxes relating to the
construction of the Mezzanine Improvements and the Tenant Improvement, permit fees and other governmental fees, losses and expenses not compensated by insurance or otherwise sustained by Lessor,
blueprinting expenses and all other ordinary and reasonable expenses incurred by Lessor applicable to the construction of the Mezzanine Improvements and the Tenant Improvements. If the estimated Total
Cost of the Mezzanine Improvements and the Tenant Improvements exceeds the Allowance, then Lessee shall pay the estimated overage to Lessor at the time a construction contract is signed for
Phase 1 or Phase 2 of the Tenant Improvements that, together with all previous amounts spent for Mezzanine Improvements and Tenant Improvements through that date, is estimated to exceed
the Allowance. Lessor shall have no obligation to cause commencement of a contract for the Phase 1 Tenant Improvements until after Lessee has paid the amount of the overage related thereto to
Lessor. Similarly, Lessor shall have no obligation to cause commencement of a contract for the Phase 2 Tenant Improvements until after Lessee has paid the amount of the overage related thereto
to Lessor. After the Allowance has been exhausted, Lessor shall have no further obligation to expend Lessor's funds on Tenant Improvements. Lessor shall place the overage paid by Lessee in an
interest-bearing account with the interest accruing to the benefit of Lessee. Lessor shall perform the services of fund control with respect to the construction costs and shall disburse Lessee's funds
in equal monthly installments based on the estimated number of months of construction for the corresponding portion of the Tenant Improvements. 

46

 

When
all the Tenant Improvements are Substantially Complete, either (1) if the Total Cost of the Mezzanine Improvements and the Tenant Improvements exceeds the sum of the Allowance plus any
amounts Lessee paid to Lessor upon the execution of the Construction Contract (plus accrued interest on Lessee's funds), then Lessee shall pay Lessor such shortfall immediately upon Lessor's request
(and Lessee's failure to make such payment shall constitute a default under the Lease), or (2) if the Total Cost of the Mezzanine Improvements and the Tenant Improvements is less than the sum
of the Allowance plus any amounts Lessee paid to Lessor upon execution of the Construction Contract (plus accrued interest on Lessee's funds), then Lessor shall refund the excess overage paid by
Lessee to Lessee. All items of Tenant Improvements shall be the property of Lessor. 

6.    Substantially Complete.    

	a.
	For
purposes hereof, (i) the Shell shall be deemed "substantially complete" at such time as Lessor has completed work in accordance with the Shell Architectural Drawings subject
to completion and correction of items on SCA's punch list, and certain other items which will not be completed until substantial completion of the Phase 1 Tenant Improvements (such as items
necessary to modify the sprinklers in accordance with the Phase 1 Tenant Improvement package and certain landscaping), and (ii) the Phase 1 Tenant Improvements shall be deemed
"substantially complete" at such time as Contractor has completed work in accordance with the Phase 1 Plans, as certified by Designer (which certification shall be obtained promptly by Lessor
upon such substantial completion), and Lessee has obtained a final or temporary certificate of occupancy from the City of Carlsbad, subject only to the completion or correction of items on the
Designer's punch list. The Premises shall be deemed Substantially Complete even though certain portions of the Premises which do not interfere with Lessee's efficient conduct of its business in the
Premises have not been fully completed, and even though Lessee's furniture, telephones, telexes, telecopiers, photocopy machines, computers and other office machines or equipment have not been
installed, the purchase and installation of which shall be Lessee's sole responsibility; provided, however, that Lessor shall permit Lessee reasonable access to the Premises prior to the substantial
completion of the Phase 1 Tenant Improvements to install such equipment and trade fixtures. Lessor shall cause the Punchlist items to be corrected as soon as reasonably possible and practical.
Lessor shall direct Contractor to clean the Premises prior to the Commencement Date, including removal of all rubbish and debris to leave the Premises in a manner consistent with the commencement of
business from first-class office premises, the cost of which shall be part of the Total Cost.

	b.
	If
Lessee delays the date of Substantial Completion due to Change Orders or the non-timely response to clarification or direction requested by the Designer, Contractor or
Lessor, such delays shall not cause any delay in the Commencement Date of the Lease nor shall it delay Lessee's obligation to pay rent for the Premises.

	c.
	Whenever
possible and practical, Lessor will cause to be utilized, for the construction of the Tenant Improvements, the items and materials designated in the Plans. However, whenever
Lessor determines in its judgment that it is not practical or efficient to use such materials, Lessor shall have the right, upon receipt of Lessee's consent, which consent shall not be unreasonably
withheld or delayed, to cause Contractor to substitute comparable items and materials. If Lessee refuses to grant such consent, and Lessor is delayed in causing the Tenant Improvements to be
Substantially Complete because of Lessee's failure to permit the substitution of comparable items and materials, such delay shall not delay the Commencement Date or Lessee's obligation to pay rent for
the Premises. 

47

  

7.    Change Orders.    If Lessee requests any changes to the Tenant Improvement Plans other than those due to acts or omissions of
Lessor or the Designer ("Change Order"), Lessor shall not unreasonably withhold its consent to any such Change Order, provided the Change Order does not materially affect the Premises' structure,
systems, equipment or appearance and does not result in the use of materials in the construction of the Tenant Improvements of a lesser quality than the materials previously approved for the Building.
Lessee shall request Change Orders in writing and if the Change Order increases the cost of the Tenant Improvements, as well as increases the amount of the construction contract, then to the extent
such Change Order increases the amount of the construction contract, Lessee shall pay such increased costs to Lessor at such time as the request is approved by Lessor and Lessor shall have no
obligation to cause the Change Order to be implemented (and the Change Order shall be of no force or effect) until Lessee pays the increased costs of the Change Order to Lessor. Any Change Order which
results in a cost savings to Lessee shall be credited to the Owner's Contingency portion of the construction contract. 

8.    No Lessor Liability.    Lessor shall not be liable for any loss, cost, damage, or expense incurred or claimed by Lessee or any
other person or party on account of the construction or installation of the Tenant Improvements or any improvements to the Premises made by Lessee, except to the extent caused by Lessor's gross
negligence, recklessness or intentional acts. As much of the Tenant Improvements for the Premises are of a very specialized and technical nature, Lessee agrees and understands that Lessor shall not be
the guarantor of, nor responsible for, the correctness or accuracy of any Plans, the compliance of such Plans with applicable laws or the operation of the Tenant Improvements in the Premises.
Notwithstanding the foregoing, Lessor hereby covenants to diligently pursue and to cooperate with Lessee in pursuing all of Lessor's warranty rights and remedies under the Construction Contract and
each Design Contract, including Lessor's rights with respect to subcontractors and vendors, as necessary to compensate Lessee for any loss, cost, damage or expense incurred or claimed by Lessee, or
any other person claiming through Lessee, on account of any defect in the construction, design or installation of the Tenant Improvements or any breach of the Construction Contract by Contractor, or
any Design Contract by the designer party thereto. The Lessor assumes no liability or responsibility resulting from the failure of the Lessee to comply with applicable governmental laws, codes and
regulations or for any defect in any of the Tenant Improvements or other alteration to the Premises made by Lessee. Lessee further agrees to indemnify, defend, and hold harmless Lessor from any
liability, loss, cost, damage or expense incurred, claimed, asserted or arising in connection with any of the foregoing. 

9.    Future Improvements by Lessee to the Premises.    In the event that Lessee shall desire to perform future improvements to the
Premises during the term of the Lease or any extension thereof, Lessee shall construct such improvements in accordance with the terms and conditions of the Lease. 

10.    Default.    Any default by Lessee or Lessor under the terms of this Agreement shall constitute a default under the Lease and
shall entitle the other to exercise all remedies set forth in the Lease. The defaulting party shall have all rights to remedy such default pursuant to the provisions of the Lease. 

11.    Reasonable Diligence.    Both Lessor and Lessee agree to use reasonable diligence in performing all of their respective
obligations and duties under this Agreement and in proceeding with the construction and completion of all Tenant Improvements in the Premises. 

12.    Dispute Resolution Procedures.    

Lessor
and Lessee agree that, except for any claim within the jurisdiction of the small claims court (which small claims court shall be the sole court of competent jurisdiction), any controversy,
dispute, or claim of whatever nature arising out of, in connection with or in relation to the interpretation, performance or breach of this Work Letter, including any claim based on contract, tort, or
statute, shall be resolved at the request of any party to this agreement through a two-step dispute resolution process administered by J.A.M.S. or another judicial mediation service
mutually acceptable to the parties 

48

 

located
in San Diego County, California. The dispute resolution process shall involve first, mediation, followed, if necessary, by final and binding arbitration administered by and in accordance with
the then existing rules and practices of J.A.M.S. or other judicial mediation service selected. In the event of any dispute subject to this provision, either party may initiate a request for mediation
and the parties shall use reasonable efforts to promptly select a J.A.M.S. mediator with experience in resolving construction disputes and commence the mediation. In the event the parties are not able
to agree on a mediator within thirty (30) days, J.A.M.S. or another judicial mediation service mutually acceptable to the parties shall appoint a mediator. The mediation shall be confidential
and in accordance with California Evidence Code § 1119 et. seq. The mediation shall be held in San Diego County, California and in accordance with the existing rules and practice of
J.A.M.S. (or other judicial and mediation service selected). The parties shall use reasonable efforts to conclude the mediation within sixty (60) days of the date of either party's request for
mediation. The mediation shall be held prior to any arbitration or court action (other than a claim within the jurisdiction of the small claims court which are not subject to this
mediation/arbitration provision and may be filed directly with a court of competent jurisdiction). Should the prevailing party in any dispute subject to this Paragraph attempt an arbitration or a
court action before attempting to mediate, the prevailing party shall not be entitled to attorney's fees that might otherwise be available to them in a court action or arbitration and in addition
thereto, the party who is determined by the arbitrator to have resisted mediation, shall be sanctioned by the arbitrator or judge. 

IF
A MEDIATION IS CONDUCTED BUT IS UNSUCCESSFUL, IT SHALL BE FOLLOWED BY FINAL AND BINDING ARBITRATION ADMINISTERED BY AND IN ACCORDANCE WITH THE THEN EXISTING RULES AND PRACTICES OF J.A.M.S. OR THE
OTHER JUDICIAL AND MEDIATION SERVICE SELECTED, AND JUDGMENT UPON ANY AWARD RENDERED
BY THE ARBITRATOR(S) MAY BE ENTERED BY ANY STATE OR FEDERAL COURT HAVING JURISDICTION THEREOF AS PROVIDED BY CALIFORNIA CODE OF CIVIL PROCEDURE SECTION 1280 ET. SEQ, AS SAID STATUTES THEN
APPEAR, INCLUDING ANY AMENDMENTS TO SAID STATUTES OR SUCCESSORS TO SAID STATUTES OR AMENDED STATUTES, EXCEPT THAT IN NO EVENT SHALL THE PARTIES BE ENTITLED TO PROPOUND INTERROGATORIES OR REQUEST FOR
ADMISSIONS DURING THE ARBITRATION PROCESS. THE ARBITRATOR SHALL BE A RETIRED JUDGE OR A LICENSED CALIFORNIA ATTORNEY. THE VENUE FOR ANY SUCH ARBITRATION OR MEDIATION SHALL BE IN SAN DIEGO COUNTY,
CALIFORNIA. 

NOTICE:
BY INITIALING IN THE SPACE BELOW YOU ARE AGREEING TO HAVE ANY DISPUTE ARISING OUT OF THE MATTERS INCLUDED IN THE "MEDIATION AND ARBITRATION OF DISPUTES" PROVISION DECIDED BY NEUTRAL BINDING
ARBITRATION AS PROVIDED BY CALIFORNIA LAW AND YOU ARE GIVING UP ANY RIGHTS YOU MIGHT POSSESS TO HAVE THE DISPUTE LITIGATED IN A COURT OR JURY TRIAL. BY INITIALING IN THE SPACE BELOW YOU ARE GIVING UP
YOUR JUDICIAL RIGHTS TO DISCOVERY AND APPEAL, UNLESS THOSE RIGHTS ARE SPECIFICALLY INCLUDED IN THE "MEDIATION AND ARBITRATION OF DISPUTES" PROVISION. IF YOU REFUSE TO SUBMIT TO BINDING ARBITRATION
AFTER AGREEING TO THIS PROVISION, YOU MAY BE COMPELLED TO ARBITRATE UNDER THE AUTHORITY OF THE CALIFORNIA CODE OF CIVIL PROCEDURE. YOUR AGREEMENT TO THIS ARBITRATION PROVISION IS VOLUNTARY. 

WE
HAVE READ AND UNDERSTAND THE FOREGOING AND AGREE TO SUBMIT DISPUTES ARISING OUT OF THE MATTERS INCLUDED IN THE "MEDIATION AND ARBITRATION OF DISPUTES" PROVISION TO NEUTRAL BINDING ARBITRATION. 

	LESSOR:	 	/s/ AJB
	 	LESSEE:	 	/s/ [Illegible]

49

 

	LESSOR:	 	LESSEE:
	

BLACKMORE AIRPORT CENTRE

California limited partnership	
 	

CANCERVAX CORPORATION

a Delaware corporation
	

By:	
 	

Blackmore Family Partners,

a California general partnership,

General Partner	
 	

By:	
 	

/s/  DAVID HALE      
 David Hale,

President and CEO
	

 	
 	

By:	
 	

/s/  ALLEN JOSEPH BLACKMORE      
 Allen Joseph Blackmore, Trustee

of the Blackmore Family Trust

Restated 1995, General Partner	
 	

By:	
 	

/s/  WILLIAM R. LARUE      
 William R. LaRue,

Vice President and CFO

50

 
 
 

EXHIBIT C
  
    PROPOSED LESSOR DESIGNED
  TENANT IMPROVEMENT SPACE PLANS    
    

51

 
 
 

EXHIBIT D
  2110 RUTHERFORD ROAD, CARLSBAD    
    

[MAP]

52

 
  
 

    EXHIBIT E    
    

	[LOGO]	 	No.	 	WFGL 10-3304

	

 	
 	
LIBERTY GUARANTEE

	

TYPE OF GUARANTEE:	
 	

    GAFGLAS LIBERTY
	
 	

PERIOD OF COVERAGE	
 	

10 YEAR
	
 	

YEARS
	

 	
 	

 	
 	

 	
 	

 	
 	

 

	

OWNER:	
 	

    BLACKMORE AIRPORT, SAN DIEGO, CA

	

 	
 	

 

	

NAME AND TYPE OF BUILDING:	
 	

    CARLSBAD RESEARCH CENTRE—LOT 80

	

 	
 	

 

	

ADDRESS OF BUILDING:	
 	

    6820 PASTEUR COURT, CARLSBAD, CA

	

 	
 	

 

	

SPECIFICATION:	
 	

    NB4M/P6
	
 	

AREA OF ROOF:	
 	

280.00
	
 	

SQUARES
	

 	
 	

 	
 	

 	
 	

 	
 	

 

	

TYPE OF FLASHING:	
 	

    1XM
	
 	

LENGTH OF FLASHING:	
 	

450
	
 	

LINEAL FEET
	

 	
 	

 	
 	

 	
 	

 	
 	

 

	

APPLIED BY:	
 	

    SUPERIOR ROOFING

	

 	
 	

 

	

DATE OF COMPLETION:	
 	

    08/15/1998
	
 	

EXPIRATION DATE:	
 	

08/15/2000

THE GUARANTEE  

        GAF MATERIALS CORPORATION ('GAFMC') guarantees to the Building Owner that, subject to the terms and conditions set forth below, GAFMC will make those repairs to
the GAFMC roofing membrane, base flashing, insulation, expansion joint covers and pre-flashed accessories (the 'GAFMC Roofing Materials') used in the construction of the above described roof as are
necessary to correct leaks while this Guarantee is in effect. This Guarantee covers such repairs to the GAFMC Roofing Materials (excluding repair or replacement of roof deck, insulation, or other
materials used in conjunction with the roofing system not sold by GAFMC) as shall be necessary solely in order to correct leaks resulting from any of the causes listed below. These repairs will be
made at no cost to the Building Owner provided that the Owner gives timely written notice to GAFMC (see below). 

Scope of Coverage—Leaks Caused by:  

	1.
	Natural
deterioration of the GAFMC Roofing Materials

	2.
	Blisters

	3.
	Bare
spots

	4.
	Fish-mouths

	5.
	Ridges

	6.
	Splits
not caused by structural failure or movement of or cracks in substrate roof base or non-GAFMC, insulation over which the GAFMC Roofing Materials are applied

	7.
	Buckles
and wrinkles

	8.
	Workmanship
In applying the GAFMC Roofing Materials

	9.
	Slippage
of membrane or base flashing 

OWNER'S RESPONSIBILITIES  

        In the event of a leak through the GAFMC Roofing Materials, the Owner must notify the GAFMC Technical Services Department, 1361 Alps Road, Bldg. 2-1, Wayne, New
Jersey 07470 In writing within thirty days after discovery of the leak. The roofing contractor is NOT an agent of GAFMC; notice to the roofing contractor is NOT notice to GAFMC. 

        The
Owner shall, at its expense, (a) perform regular inspections and maintenance during this Guarantee, (b) keep records of all inspections and maintenance performed, and
(c) perform repairs to this roof or to other building components identified during inspections by GAFMC as being necessary to preserve the integrity of the GAFMC Roofing Materials. Failure of
the Owner to
perform this work promptly following written notification by GAFMC may result in cancellation of this guarantee if the Owner's failure results in damage to the GAFMC Roofing Materials. 

        The
Owner shall, at its expense, remove (and, if desired, subsequently replace) any materials and equipment that impede inspection and repair of the GAFMC Roofing Materials, such as HVAC
units and satellite dishes mounted so that there is no 

53

 

functional
access to the roof system, and precast concrete or rubber pavers, wood decking and steel grating that are installed over the GAFMC Roofing Materials. 

        In
an emergency, the Owner may authorize or perform temporary repairs to minimize damage to the building or its contents. Such work will not result in the cancellation of this Guarantee
provided that the temporary repairs are reasonable and customary, and do not result in permanent damage to the GAFMC Roofing Materials. The Owner is responsible for all expenses associated with
temporary repairs. 

EXCLUSIONS FROM COVERAGE  

        This Guarantee shall NOT cover the following conditions or any damages which may arise therefrom. 

	1.
	Roof
maintenance or correction to conditions other than leaks.

	2.
	Unusual
weather conditions or natural disasters including, but not limited to, windstorms, hall, floods, hurricanes, lightning, tornados, and earthquakes.

	3.
	Damage
to the roof constructed of the GAFMC Roofing Materials due to: (a) settlement, distortion, movement, failure or cracking of the roof deck, walls, or foundations to the
building; (b) Improper installation to non-GAFMC insulation or defects or failure of any material used in any roof base or insulation not manufactured by GAFMC over which the GAFMC Roofing
Materials are applied; (c) infiltration or condensation of moisture in, through or around the walls, copings, building structure, or underlying or surrounding materials including tie-ins to
adjacent roof systems; (d) defects in design; (e) the performance, design, or application of non-GAFMC materials such as roof decks, metal work, expansion and control joints, pitch
pockets, walkways, work platforms and recreational surfacings; (f) expansion or contraction of any metal flashing or other metal work; (g) underlying materials or structures having
failed or ceased to conform to GAFMC's or other applicable specifications as to roof slopes or other requirements; (h) chemical attack on the membrane; (i) vandalism; or
(j) negligence by the Owner in maintaining the GAFMC Roofing Materials.

	4.
	Damage
to the building or its contents.

	5.
	Changes
in usage of the building unless approved in writing in advance by GAFMC.

	6.
	Damage
resulting from any new installations on or through the GAFMC Roofing Materials or from traffic of any nature on the roof.

	7.
	Temporary
repairs to the GAFMC Roofing Materials authorized by the Owner.

	8.
	Any
repairs or other applications to the GAFMC Roofing Materials after the date to completion, unless performed in a manner acceptable to and approved by GAFMC in writing in advance.
NOTE: In no event shall new penetrations be covered under the terms of guarantee.

	9.
	Any
damage occurring more than thirty days after the discovery by the Owner or its agent of a leak, unless GAFMC is notified of such leak within thirty days of its discovery.

	10.
	Areas
of roof which pond water. 

        No
representative, employee, or agent of GAFMC, or any other person, has any authority to assume for GAFMC any additional or other liability or responsibility in connection with the roof
described above. GAFMC shall not be responsible for or liable for any change or amendment to the GAFMC roof specifications in regard to the construction of the roof described above, unless the change
or amendment to the specifications is approved in writing by an authorized GAFMC Technical Services Manager. 

        This
Guarantee is assignable to another owner of the building for the remaining term ONLY if the following conditions are met: 1) The request is in writing within 30 days after
ownership transfer; 2) The membrane is inspected and any required repairs are completed at Owner's expense; 3) The proposed assignment is approved in writing by an authorized GAFMC
Technical Services Manager; and 4) An assignment fee of $500 is paid to GAFMC. This Guarantee is NOT otherwise assignable, directly or Indirectly. 

        CANCELLATION
OF THIS GUARANTEE WILL RESULT IF THE ROOF IS DAMAGED BY ANY CAUSE LISTED ABOVE UNDER "EXCLUSIONS FROM COVERAGE" IF THE DAMAGE AFFECTS THE INTEGRITY OR WATERTIGHTNESS OF THE
ROOF, AND THE OWNER DOES NOT PROMPTLY MAKE REPAIRS FOLLOWING WRITTEN NOTIFICATION BY GAFMC TO RECTIFY THE DAMAGE AND PRESERVE THE INTEGRITY OF THE ROOF. 

        THIS
GUARANTEE IS EXPRESSLY IN LIEU OF ANY OTHER GUARANTEES AND/OR WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING ANY IMPLIED WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR
PURPOSE, AND OF ANY OTHER OBLIGATIONS OR LIABILITY ON THE PART OF GAF MATERIALS CORPORATION, whether any claim against it is based upon strict liability, negligence, breach of warranty or any other
theory or cause of notion. In NO event shall GAF Materials Corporation be liable for any CONSEQUENTIAL OR INCIDENTAL DAMAGES of any kind. 

NOTE:
This Guarantee becomes effective only when bills for installation and supplies have been paid in full to the roofing contractor and materials suppliers, and the Guarantee charge has been paid to
GAF Materials Corporation. 

GAFMC
MATERIALS CORPORATION

1301 ALPS ROAD

WAYNE, NJ 07470 

FORM
COMTS581 

	 	 	By	 	/s/ [Illegible]

	 	 	 	 	Authorized Signature
	 	 	Date March 18, 1999

54

  

 
 

EXHIBIT F    
    
    CONDITION OF BUILDING UPON POSSESSION    
    

	DATE:	 	August 31, 2001
	LOCATION:	 	2110 Rutherford Road, Carlsbad
	TENANT:	 	CancerVax Corporation

	OFFICE AREA
 
	 	COMMENTS

	CARPET	 	 
	CEILING	 	 
	DOORS	 	 
	HVAC	 	 
	LIGHTS	 	 
	WINDOW COVERINGS	 	 
	WALLS	 	 
	WINDOWS	 	 
	
BATHROOMS
	
 	

 
	DOORS	 	 
	FANS	 	 
	FIXTURES	 	 
	FLOOR	 	 
	LIGHTS	 	 
	MIRRORS	 	 
	PLUMBING	 	 
	WALLS	 	 
	
WAREHOUSE
	
 	

 
	CEILING	 	 
	FLOOR	 	 
	LIGHTS	 	 
	MAN DOORS	 	 
	SKYLIGHTS	 	 
	TRUCK DOORS	 	 
	WALLS	 	 
	
MISCELLANEOUS
	
 	

 
	KITCHEN AREA	 	 
	SIGNAGE	 	 

[SEAL]

55

 
 
 

EXHIBIT G    
    
    LANDLORD'S WAIVER AND CONSENT (OWNER)    
    

        THIS LANDLOARD'S WAIVER AND CONSENT is made by Blackmore Airport Centre, a California Limited Partnership
("Owner") whose address is P.O. Box 1810, Rancho Santa Fe, California 92067 in favor of                  (hereinafter referred to as "Lender") with an
address of                  and affects the
real property commonly know as 2110 Rutherford Road, Carlsbad, California 92008 (hereinafter referred to as the "Real Property" or the "Premises") in connection with the Lender entering into the
following agreements dated                  and other agreements related thereto (hereinafter collectively referred to as the "Agreements") with CancerVax
Corporation (hereinafter jointly and severally
referred to as "Borrower"), which Agreements, among other things were given by Borrower to Lender for the purpose of securing the repayment of all obligations and the performance of all duties now or
hereafter owing by Borrower to Lender, of every kind and description (collectively the "Obligations"). Borrower is a tenant of Owner for the Premises pursuant to that certain lease agreement dated
                  ("Lease"). This Waiver does not amend any of the terms of the Agreements and reference is made to the Agreements for further information as to
their terms. 

        Pursuant
to the Agreements, Lender has loaned or may hereafter loan monies to Borrower secured by, among other collateral, Borrower's now-owned and hereafter acquired goods,
merchandise, inventory, equipment, furniture, furnishings, fixtures, trade fixtures, machinery and tools, together with all additions, substitutions, replacements, and improvements to the same
(hereafter referred to as "Goods"), which Goods are or are to be located on and may be affixed to the Premises or improvements thereon. 

        Owner
agrees as follows: 

        1.    Goods Remain Personal Property    The Goods shall at all times be and remain personal property, and the Goods
shall not be deemed a fixture or part of the Real Property. Owner disclaims any interest in the Goods and will not assert any statutory or possessory lien against any of the Goods. 

        2.    Notice of Default    Owner will send to Lender by certified mail, at its address above, a copy of any written
notice Owner sends to Borrower, at the same time as it sends such notice to Borrower, of a default by Borrower under the Lease, and allow Lender at Lender's option, thirty (30) days from
Lender's receipt of such notice in which to cure or request Borrower to cure such default or to take possession of the Premises in accordance with Paragraph 3 below. 

        3.    License to Lender    Conditioned upon Lender's performance of the items described in Paragraph 4, Owner
grants Lender the option, as set forth below, to enter into possession of the Premises to do any or all of the following with respect to the Goods: inspect them, assemble them, have them appraised,
display them, sever them, remove them, maintain them, prepare them for sale or lease, repair them, lease them, and transfer and/or sell them at one or more public auctions or private sales. Lender
shall have the foregoing rights for a period of up to thirty (30) days (at Lender's discretion and with Owner's prior approval), following Lender obtaining possession of the Premises either by
Borrower or Owner placing Lender in possession of the Premises or abandonment of the Premises by Borrower to Lender or otherwise, but in no event shall Lender be under any obligation to take
possession of the Premises. Any extensions of the foregoing period shall be with the written consent of Owner. Lender shall repair prior to vacating the Premises, at its cost, any structural or
cosmetic damage to the Premises caused by the removal of the Goods by Lender. In the event Lender does not remove said Goods from the Premises within the thirty (30) days period, or Lender
fails to take possession of the Premises within ten (10) days after Owner's notice of availability, Lender shall have no further right to said inventory and Owner will execute the right to
distrain on the Goods as Owner deems necessary. 

56

 

        4.    Rent Payable By Lender    If the rent payable from the Borrower to the Owner has not been paid for a period
during which Lender may take possession of the Premises pursuant to Paragraph 3 above, then Owner shall condition Lender's right to take or keep possession of the Premises upon Lender agreeing
(within ten (10) days of Landlord's request), in writing, to pay in advance such rent which is payable to Owner (prorated on a daily basis) for the actual number of days Lender is in possession
of the Premises, up to 60 days or such longer period as may be agreed to in writing between Owner and Lender. Lender shall have no obligation to remedy any defaults of Borrower or to pay any
share of real property taxes or other taxes, insurance, maintenance costs, or other sums payable by Borrower (whether or not denominated as "rent" in the Lease) for any period prior to Lender taking
possession. No agreement by Lender to pay such rent shall be binding on Lender unless set forth in a written agreement signed by Lender. Lender's failure to agree to pay such rent within ten
(10) days of Landlord's request shall cause this waiver and consent to terminate immediately. 

        5.    General    This Waiver and Consent shall continue until the earlier of such time as all Obligations have been
paid and performed in full and Lender's failure to take possession of the Premises within ten (10) days after Owner notifying Lender that it may take possession of the Premises. This Waiver and
Consent shall be governed and controlled by, and interpreted under, the laws of the State of California and shall inure to the benefit of, and be binding upon, the successors, heirs and assigns of
Owner and Lender. 

	DATED:	 	    
	 	OWNER:	 	BLACKMORE AIRPORT CENTRE,

A CALIFORNIA LIMITED PARTNERSHIP
	

 	
 	

 	
 	

By:	
 	

Blackmore Family Partners,

A California General Partnership,

General Partner
	

 	
 	

 	
 	

By:	
 	

    
 Allen Joseph Blackmore, Trustee

of the Blackmore Family Trust

Restated 1995, General Partner

[SEAL]

57

 
 
 

AMENDMENT OF LEASE
  August 16, 2002    

That
certain Lease dated August 31, 2001, by and between Blackmore Airport Centre, a California limited partnership, Lessor, and CancerVax Corporation, Lessee, in connection with the property
located at 2110 Rutherford Road, Carlsbad, California, is hereby amended with respect to the following provisions: 

	65.
	(NEW)
GENERATOR MAINTENANCE AND LOAD TESTING:    It is understood by the parties hereto that the building is equipped with a
300KW Standby Generator which requires quarterly maintenance and service. Notwithstanding anything contrary contained in Paragraph 7 of the lease, Lessor shall procure and maintain a generator
maintenance contract providing for quarterly service. Lessee shall reimburse Lessor for this service. Such service shall be $420.00 per quarter, subject to increase and shall be included in the annual
operating expense budget for the building. 

In
addition, the generator must be load tested on an annual basis. Such service shall be $445.00 per year, subject to increase, and shall be included in the annual operating expense budget for the
building. 

All
other terms and conditions of the Lease, as amended, shall remain unchanged and in full force and effect. 

	LESSOR:	 	LESSEE:
	

BLACKMORE AIRPORT CENTRE, A CALIFORNIA LIMITED PARTNERSHIP	
 	

CANCERVAX CORPORATION
	

By:	

Blackmore Family Partners,

A California General Partnership,

General Partner	
 	

 	

 
	

By:	

/s/  ALLEN JOSEPH BLACKMORE      
 Allen Joseph Blackmore,

Trustee of the Blackmore

Family Trust, restated 1995,

General Partner	
 	

By:	

/s/  DAVID F. HALE      
 David F. Hale,

President and CEO
	

Date	

9-3-02
	
 	

Date	

8/26/02

	

 	

 	
 	

By:	

/s/  WILLIAM R. LARUE      
 William R. LaRue

Vice President and CFO
	

 	

 	
 	

Date:	

8/26/02

58

 
 
 

AMENDMENT OF LEASE
  May 24, 2004    

That
certain Lease dated August 31, 2001, as amended, by and between Blackmore Airport Centre, a California limited partnership, Lessor, and CancerVax Corporation, Lessee, in connection with
the property located at 2110 Rutherford Road, Carlsbad, California, is hereby amended with respect to the following provisions: 

        Subparagraph
51 (b) is hereby deleted in its entirety and shall be replaced with the following: 

SECURITY DEPOSIT:  

	b.
	Lessor
and Lessee acknowledge that the amount of the Letter of Credit may fluctuate during the Term of the Lease. On or before the 45th day
following the end of each quarter of the Lease Term, Lessee shall provide to Lessor (x) a financial statement for the immediately preceding  quarter certified as true,
complete and correct by the CFO of Lessee that includes an accurate cash balance of the Lessee and (y) supporting bank
statements also certified by the CFO to be true, complete and correct (such statements as of a date no earlier than the last day of the immediately preceding  quarter) which indicate the balance of cash
held by the Lessor in such institution(s) as of that date. Lessor shall be required to maintain the
following amount of Letter of Credit, based on the amount of cash shown on the certified financial statements and certified bank statements: 

All
other terms and conditions of the Lease, as amended, shall remain unchanged and in full force and effect. 

	LESSOR:	 	LESSEE:
	

BLACKMORE AIRPORT CENTRE,

A CALIFORNIA LIMITED PARTNERSHIP	
 	

CANCERVAX CORPORATION
	

By:	

Blackmore Family Partners,

A California General Partnership,

General Partner	
 	

 	

 
	

By:	

/s/  ALLEN JOSEPH BLACKMORE      
 Allen Joseph Blackmore,

Trustee of the Blackmore

Family Trust, restated 1995,

General Partner	
 	

By:	

/s/  DAVID F. HALE      
 David F. Hale,

President and CEO
	

Date	

July 7, 2004
	
 	

Date	

June 25, 2004

	

 	

 	
 	

By:	

/s/  WILLIAM R. LARUE      
 William R. LaRue

Vice President and CFO
	

 	

 	
 	

Date:	

June 25, 2004

59

  

 
 

EXHIBIT B    
    
    DESCRIPTION OF SUBLEASED PREMISES    
    

        The ground floor (consisting of 46,527 square feet) of the office building located at 2110 Rutherford Road, Carlsbad, California. 

60

 
 
 

EXHIBIT C    
    
    BASE RENT SCHEDULE    
    

        Beginning on August 1, 2006, the Base Rent to be paid by the Subtenant to Sublandlord shall be as follows: 

	May 1, 2006 through July 31, 2006	 	—	 	No Base Rent
	August 1, 2006 through June 30, 2007	 	—	 	$81,422.25 ($1.75 per rentable square foot) per month
	July 1, 2007 through June 30, 2008	 	—	 	$83,864.92 ($1.80 per rentable square foot) per month
	July 1, 2008 through June 30, 2009	 	—	 	$86,380.87 ($1.86 per rentable square foot) per month
	July 1, 2009 through June 30, 2010	 	—	 	$88,972.29 ($1.91 per rentable square foot) per month
	July 1, 2010 through June 30, 2011	 	—	 	$91,641.46 ($1.97 per rentable square foot) per month
	July 1, 2011 through June 30, 2012	 	—	 	$94,390.70 ($2.03 per rentable square foot) per month

        Subtenant
agrees to pay to Sublandlord the Base Rent according to the terms and conditions set forth in Section 3 of this Sublease. 

61

 
 
 

EXHIBIT D-1    
    
    CARD ACCESS PLAN    
    

62

 
 
 

EXHIBIT D    
    

[MAP]

63

 
 
 

EXHIBIT D-2    
    
    DEMISING WALL IMPROVEMENTS    
    

64

 
[MAP]

65

 
 
 

EXHIBIT E    
    
    LIST OF FURNITURE AND EQUIPMENT    
    

(12) Square
tables with 48 chairs

(1) 6' conference table and (6) chairs

(1) 8' conference table and 8 chairs

(9) 30 × 60 conference table and 22 chairs

(51) cubicles

(28) sets of office furniture

(2) sets mail slots and (6) base storage cabinets

(7) ducted fume hoods

Server racks

Telephones

(1) lot of file cabinets

(1) lot of fire proof files

All attached casework and cabinetry 

66

 
 
 

EXHIBIT F    
    
    SECOND FLOOR OCCUPANT ACCESS AREAS    
    

67

 
 
 

EXHIBIT F    
    

[MAP]

68

  

 
 

CONSENT TO SUBLEASE    
    

	1.
	Master Landlord's Consent. Master Landlord hereby consents to the attached Amended and Restated Sublease Agreement between Cancervax
Corporation and Genoptix, Inc., dated May 1, 2006. This consent is granted only on the terms and conditions stated in Paragraph 2 below. Master Landlord is not bound by any of the
terms, covenants, or conditions of the Sublease. The Sublease is subject and subordinate to the Master Lease and does not in any way modify the Master Lease.

	2.
	Conditions and Limits to Consent; Nonrelease of Sublandlord; Further Transfers; Recapture Rights. Neither the Sublease nor this Consent
will:

	(a)
	release
Sublandlord from any liability, whether past present or future, under the Master Lease;

	(b)
	alter
the primary liability of Sublandlord to pay the rent and perform all of the Lessee's obligations under the Master Lease (including the payment of all bills rendered by Master
Landlord for charges incurred by Subtenant for services and materials supplied to the Subleased Premises);

	(c)
	be
construed as a waiver of Master Landlord's right to consent to any proposed transfer after the date hereof by Sublandlord under the Master Lease or Subtenant under the Sublease, or
as a consent to any portion of the Subleased Premises being used or occupied by any other party;

	(d)
	grant
any rights to Subtenant greater than those rights granted to Sublandlord under the Master Lease;

	(e)
	be
deemed consent to any other transfer;

	(f)
	be
construed as consent by Master Landlord to a term in the Sublease beyond the term of the Master Lease;

	(g)
	require
Master Landlord to recognize Subtenant in the event of a default in the Master Lease by Sublandlord;

	(h)
	enlarge
or in any manner increase Master Landlord's obligations or duties under the Master Lease;

	(i)
	create
obligations or costs to Master Landlord with regard to the Sublease;

	(j)
	require
Master Landlord to proceed any action under the Master Lease or this Agreement against either Sublandlord or Subtenant without first exhausting Master Landlord's remedy
against the other; or 

69

 

	(k)
	modify,
waive, amend, or otherwise affect any provision of the Master Lease. 

	MASTER LANDLORD:

BLACKMORE AIRPORT CENTRE,

A California limited partnership	 	 
	

By:	
 	

Blackmore Family Partners,

a California General Partnership,

General Partner	
 	

 
	

By:	
 	

/s/ Allen Joseph Blackmore
 Allen Joseph Blackmore,

Trustee of the Blackmore

Family Trust, restated 1995,

General Partner	
 	

 

70

 
 
 

AMENDMENT OF LEASE
  May 3, 2006    
    

That
certain Lease dated August 31, 2001, as previously amended, by and between Blackmore Airport Centre, a California limited partnership, Lessor, and CancerVax Corporation, Lessee, in
connection with the property located at 2110 Rutherford Road, Carlsbad, California, is hereby amended with respect to the following provisions: 

A.    No Alterations without Lessor's Prior Written Consent.    Notwithstanding the provisions of Subparagraph 7.4 of the Lease,
Lessee shall not make any further improvements, alterations, additions or changes to the Premises without Lessor's prior written consent. Lessor may withhold or condition its consent if Lessor
determines in its sole and absolute discretion that the requested alterations may negatively impact the value of the Premises or future lease or sale of the Premises, may affect the structure of the
Premises, result in Lessor being required to perform additional work on the Premises that Lessor could otherwise avoid or defer, cause an increase in the premiums for hazard or liability insurance or
overload the floor load capacity or unduly burden the installed systems (including, without limitation, plumbing, HVAC, electrical, fire/life safety and elevator) in the Premises. 

B.    Fixed Letter of Credit Amount.    Subparagraph 51(b) is hereby deleted in its entirety and shall be replaced with the
following: 

"Lessor
and Lessee acknowledge that the amount of the Letter of Credit may fluctuate during the Term of the Lease. On or before the 45th day following the end of each quarter of the Lease Term, Lessee
shall provide to Lessor (x) a financial statement of the immediately preceding quarter certified as true, compete and correct by the CFO of Lessee that includes an accurate cash balance of the
Lessee and (y) supporting bank statements also certified by the CFO to be true, complete and correct (such statements as of a date no earlier than the last day of the immediately preceding
quarter) which indicate the balance of cash held by the Lessee in such institution(s) as of that date. Lessee shall be required to maintain the following amount of Letter of Credit, based on the
amount of cash shown on the certified financial statements and certified bank statements: 

1.
If the cash balance is less than $5,000,000, then Lessee shall deliver to Lessor with the financial statements and bank statements a replacement Letter of Credit in the amount of $1,900,000; 

2.
If the cash balance is greater than or equal to $5,000,000, then the amount of the Letter of Credit shall be $1,350,000. 

If
the amount of the Letter of Credit at the time of delivery of the financial statements and bank statements is to be modified, than Lessor shall cooperate in returning the Letter of Credit it then
holds as soon as it receives the replacement Letter of Credit in the modified amount." 

71

 

All
other terms and conditions of the Lease, as amended, shall remain unchanged and in full force and effect. To the extent that there is any conflict between the Lease, as previously amended, and
this Amendment of Lease, this Amendment shall control. 

	LESSOR:	 	LESSEE:
	

BLACKMORE AIRPORT CENTRE,

A California limited partnership	
 	

CANCERVAX CORPORATION
	

By:	
 	

Blackmore Family Partners,

a California General Partnership,

General Partner	
 	

By:	
 	

/s/ William R. LaRue
 William R. LaRue,

Vice President and CFO
	

 	
 	

By:	
 	

/s/ Allen Joseph Blackmore
 Allen Joseph Blackmore,

Trustee of the Blackmore

Family Trust, restated 1995,

General Partner	
 	

 	
 	

 

72

QuickLinks

Exhibit 10.8

AMENDED AND RESTATED SUBLEASE AGREEMENT

RECITALS

[GRAPHIC]  AMERICAN INDUSTRIAL REAL ESTATE ASSOCIATION

STANDARD INDUSTRIAL/COMMERCIAL SINGLE-TENANT LEASE—NET (Do not use this form for Multi-Tenant Property)

ADDENDUM TO STANDARD INDUSTRIAL/COMMERCIAL SINGLE-TENANT LEASE—NET BY AND BETWEEN BLACKMORE AIRPORT CENTRE, A CALIFORNIA LIMITED PARTNERSHIP, LESSOR AND CANCERVAX CORPORATION, LESSEE DATED AUGUST 31,
2001

EXHIBIT A "FOR CONSTRUCTION" SHELL BUILDING PLANS DELIVERED TO CANCER VAX ON AUGUST 31, 2001

EXHIBIT "B" TENANT IMPROVEMENT AGREEMENT

EXHIBIT C PROPOSED LESSOR DESIGNED TENANT IMPROVEMENT SPACE PLANS

EXHIBIT D 2110 RUTHERFORD ROAD, CARLSBAD

EXHIBIT E

EXHIBIT F CONDITION OF BUILDING UPON POSSESSION

EXHIBIT G LANDLORD'S WAIVER AND CONSENT (OWNER)

AMENDMENT OF LEASE August 16, 2002

AMENDMENT OF LEASE May 24, 2004

EXHIBIT B DESCRIPTION OF SUBLEASED PREMISES

EXHIBIT C BASE RENT SCHEDULE

EXHIBIT D-1 CARD ACCESS PLAN

EXHIBIT D

EXHIBIT D-2 DEMISING WALL IMPROVEMENTS

EXHIBIT E LIST OF FURNITURE AND EQUIPMENT

EXHIBIT F SECOND FLOOR OCCUPANT ACCESS AREAS

EXHIBIT F

CONSENT TO SUBLEASE

AMENDMENT OF LEASE May 3, 2006

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