Document:

Exhibit 4.1

                       [LOGO OF TDK MEDIACTIVE, INC.]

NUMBER       Incorporated Under the Laws of the State of Delaware    SHARES
              50,000,000 AUTHORIZED COMMON STOCK, $.001 PAR VALUE

                                                              SEE REVERSE FOR
                                                           CERTAIN DEFINITIONS

                                                           CUSIP 87236L 10 6

THIS CERTIFIES THAT

IS THE REGISTERED HOLDER OF

   FULLY PAID AND NON-ASSESSABLE SHARES OF COMMON STOCK, $.001 PAR VALUE OF

                             TDK MEDIACTIVE, INC.

transferable only on the books of the Corporation in person or by attorney
upon surrender of this Certificate properly endorsed.  This Certificate and
the shares represented hereby are issued and shall be subject to all the
provisions of the Certificate of Incorporation, to all of which the holder by
acceptance hereby assents.

     IN WITNESS WHEREOF, the Corporation has caused this Certificate to be
endorsed by the facsimile signatures of its duly authorized officers and to be
sealed with the facsimile seal of the Corporation.

     This Certificate is not valid unless duly countersigned by the Transfer
Agent and Registrar.

Dated:

/s/ Eugene L. Code               [CORPORATE SEAL]   /s/ Shin Tanabe
    Eugene L. Code, Secretary                           Shin Tanabe, President

                                             Countersigned and Registered:
                                             CORPORATE STOCK TRANSFER, INC.
                                             3200 Cherry Creek South Drive
                                             Suite 430, Denver, CO 80209

                                             By:
                                                 ---------------------------
                                                 Transfer Agent and Registrar
                                                 Authorized Officer

<PAGE>
<PAGE>
                          [REVERSE OF CERTIFICATE]

                           TDK MEDIACTIVE, INC.
                       Corporate Stock Transfer, Inc.
                         Transfer Fee: As Required

     The following abbreviations, when used in the inscription on the face of
this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

TEN COM - as tenants in common      UNIF GIFT MIN ACT -      Custodian
TEN ENT - as tenants by the                             -----          ------
            entireties                                 (Cust)         (Minor)
JT TEN - as joint tenants with right of          under Uniform Gifts to Minors
           survivorship and not as tenants       Act
           in common                                --------------------------
                                                         (State)

       Additional abbreviations may also be use though not in the above list.

     For value received,                          hereby sell, assign and
                        -------------------------
                Please insert social security or
               other identifying number of assignee
                ------------------------------------
transfer unto /                                    /
               ------------------------------------------------------------

---------------------------------------------------------------------------
(please print or typewrite name and address including postal zip code of
 assignee)

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                   Shares of the Common Stock represented by the within
------------------
Certificate, and do hereby irrevocably constitute and appoint
                                                              ----------------
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to transfer the said stock on the books of the within-named Corporation with
full power of substitution in the premises.

Dated,                         20
       -----------------------   ----

SIGNATURE GUARANTEED:                     X
                                            --------------------------------
                                          X
                                            --------------------------------

THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON
THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR
ENLARGEMENT OR ANY CHANGE WHATSOEVER.  THE SIGNATURE(S) MUST BE GUARANTEED BY
AN ELIGIBLE GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and Loan
Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED SIGNATURE
GUARANTEE MEDALLION PROGRAM.<PAGE>

                                                                    EXHIBIT 10.1

                             EMPLOYMENT AGREEMENT

     THIS AGREEMENT dated November 9, 2000, is made and entered into by and
between ZymoGenetics, Inc., a Washington corporation (the "Company") and Bruce
L.A. Carter (the "Executive").

     1.  Employment.  The Company hereby employs the Executive and the Executive
         ----------
hereby accepts employment by the Company upon the terms and conditions contained
in this Agreement and for the period (hereinafter called the "Term of
Employment') specified in Section 3 below.

     2.  Duties.  The Executive shall, during the Term of Employment, serve the
         ------
Company under the direction of the Board of Directors of the Company (the
"Board"), faithfully, diligently and competently and to the best of his ability,
and shall devote his full business time to his employment hereunder. The
Executive shall have the title and office of President and CEO of the Company in
which capacity he shall have responsibility for the business and affairs of the
Company, subject to the control of the Board. Executive also shall serve as a
director of the Company. Executive's duties as President and CEO of the Company
shall not be curtailed below those normally exercised by presidents and CEOs of
similar companies. Executive may devote reasonable periods of time to (a)
engaging in personal investment activities, (b) serving on the Board of
Directors of other corporations with the consent of the Compensation Committee
of the Board, if such service would not otherwise be prohibited by Section 9
hereof (it is understood and agreed that the Executive can continue to serve as
a member of the Board of Directors of the following companies: AVI, Trega and
Bioimage A/S), and (c) engaging in charitable or community service activities,
so long as none of the foregoing additional activities materially interfere with
Executive's duties under the agreement.

     3.  Terms of Employment; Termination.
         --------------------------------

         (a) The company shall employ the Executive, and the Executive shall
serve the Company, for a period commencing on the date hereof and terminating on
the earliest to occur of the following:

             (i)  four (4) years from the date hereby of this agreement with a
daily "evergreen" feature effective on the third anniversary, so that the
remaining term will always be at least one (1) year, subject to either party
being able, by written notice, to stop further operation of this evergreen
feature; or

             (ii) the date on which the Company gives written notice to the
Executive of termination due to the Executive's being unable, because of
physical or mental illness or disability, to perform his duties hereunder;
provided, however, that such notice may
<PAGE>

not be given by the Company unless the Executive has been unable, because of
such illness or disability, to perform his duties hereunder for an aggregate of
one hundred twenty (120) working days or ninety (90) consecutive working days
during the twelve calendar months preceding the month in which such notice is
given; or

               (iii)  the death of the Executive; or

               (iv)   the date on which the Company gives written notion to the
Executive of termination for Cause;

               (v)    thirty (30) days after the date on which the Company gives
Executive notice of termination without Cause; or

               (vi)   ninety (90) days after the date on which the Executive
gives written notice to the Company of termination for Good Reason.

          (b)  Where reference is made in this Agreement to termination being by
the Company for Cause, Cause shall be limited to the following:  Executive has
(a) been convicted of, or pleaded guilty or nolo contendere to, a felony
involving theft, moral turpitude or fraud, including fraud against the Company
or under federal or state security laws, or (b) engaged in gross neglect or
gross misconduct, or habitual misuse of drugs or alcohol, resulting in any case,
in material injury to the business, reputation or affairs of the Company.

          (c)  Where reference is made in this Agreement to termination being by
Executive for Good Reason, Good Reason shall mean (i) the assignment to
Executive of duties inconsistent in any respect with Executives position,
including status, offices, titles and reporting relationships, authority, duties
or responsibilities as contemplated by this Agreement, or any other action by
the Company which results in the significant diminution in such a position,
authority, duties or responsibilities, in both cases, excluding any isolated,
immaterial, or inadvertent action not taken in bad faith and which is remedied
by the Company promptly after receipt of a written notice thereof given by
Executive to the Board; (ii) any failure by the Company to provide compensation
and benefits to Executive described in this Agreement, other than an isolated,
immaterial, or inadvertent failure not taken in bad faith and which is remedied
by the Company promptly after receipt of written notice thereof given by
Executive to the Board; (iii) failure of the Company to obtain the assumption in
writing of its obligations under the Agreement by any successor to all or
substantially all of the assets of the Company within thirty (30) calendar days
after the consummation of a merger, consolidation, sale or similar transaction;
(iv) any other material breach by the Company of its obligations to Executive
under this Agreement which is not remedied by the Company promptly after receipt
of written notice thereof given by the Executive to the Board; (v) relocation of
the Company's headquarters more than 20 miles from its current headquarters in
Seattle without Executive's consent; (vi) following a Change in Control (as
defined in Section 5 hereof), the Executive ceases to hold the position of
President and Chief Executive Officer of the parent or combined entity resulting
from such Change in Control; or

                                      -2-
<PAGE>

(vii) even if there is no Change in Control, but the Company enters into a
merger, partnership or similar transaction, which results in a person other than
the Executive becoming President and CEO of the new combined entity.
Notwithstanding the foregoing, an event shall not constitute Good Reason
hereunder unless the Executive has given notice of termination pursuant to this
Section 3(c) within six (6) months of such event constituting Good Reason.

          (d)  No termination of the Term of Employment by either the Company or
the Executive for any reason will affect in any way any accrued benefits to
which the Executive may be entitled as of the date of termination.

     4.   Events Triggering Severance Benefits.  Upon the termination of
          ------------------------------------
Executive's employment by the Company without Cause or by the Executive for Good
Reason, Executive will be entitled to receive the severance benefits described
in Section 5 below.

     5.   Severance Benefits.
          ------------------

     In the event of a termination of employment described in Section 4 above,
Executive will be entitled, in lieu of any other severance benefits (other than
those described elsewhere herein), to:

          (a) Continuation of Executive's then current annual salary for a
period of two (2) years.  If requested by executive, and agreed to by the
Company, the present value of such salary continuation will be paid in a lump
sum using a six percent (6%) annual discount factor.

          (b) Payment of a performance cash bonus at target for the year of
termination, prorated for the portion of the year elapsed through the date of
Executive's termination.

          (c) Payment of any benefits, in accordance with their terms, accrued
to the date of termination, but previously unpaid.

          (d) Continuation of health care benefits for Executive and his
dependents for two (2) years after the date of termination or until Executive
receives substantially the same health care benefits from another employer,
whichever occurs first.

          (e) Only if such termination occurs on or after a Change in Control
(as hereafter defined), full vesting of all stock options, restricted stock and
performance shares. Notwithstanding the foregoing, this provision will also
apply if Executive is terminated pursuant to Section 3(a)(ii) or 3(a)(iii)
hereof.

          (f) In the event such termination occurs prior to a Change in Control,
only with respect to the Executive's stock option grant referred to in Section
7(a) hereof, Executive shall be vested in a number of shares equal to the
greater of (i) 100,000 shares, or (ii) the number of shares that otherwise would
be vested on the date of Executive's

                                      -3-
<PAGE>

termination. The parties understand and agree that any future grants of stock
options that Executive may receive pursuant to the Company's stock-based bonus
program shall be entitled to the accelerated vesting described in the preceding
sentence.

          (g)  As used herein, a "Change in Control" shall mean:

               (i)  The acquisition by any individual, entity or group (within
the meaning of Section 13(d)(3) or 14(d)(2) of the Securities Exchange Act of
1934, as amended (the "Exchange Act")) (a "Person"), other than any one or more
Series B Investor (as defined in the ZymoGenetics Series B Preferred Stock
Purchase Agreement October 20, 2000), either directly or indirectly through one
or more affiliated entities (collectively "Series B Purchasers"), of beneficial
ownership (within the meaning of Rule 13d-3 promulgated under the Exchange Act)
of 50% or more of either (x) the then outstanding shares of common stock of the
Company (the "Outstanding Company Common Stock") or (y) the combined voting
power of the then outstanding voting securities of the Company entitled to vote
generally in the election of directors (the "Outstanding Company Voting
Securities"); provided, however, that for purposes of this subsection (f)(i),
the following acquisitions shall not constitute a Change in Control: (A) any
acquisition by any employee benefit plan (or related trust) sponsored or
maintained by the Company or (B) any acquisition by any corporation pursuant to
a transaction which complies with clauses (A), (B), and (C) of subsection
(f)(ii) of this Section 5; or

               (ii) Consummation of a reorganization, merger or consolidation or
sale or other disposition of all or substantially all of the assets of the
Company (a "Business Combination"), in each case, unless, following such
Business Combination: (A) all or substantially all of the individuals and
entities who were the beneficial owners, respectively, of the Outstanding
Company Common Stock and Outstanding Company Voting Securities immediately prior
to such business Combination beneficially own, directly or indirectly, more than
50% of, respectively, the then outstanding shares of common stock and the
combined voting power of the then outstanding voting securities entitled to vote
generally in the election of directors, as the case may be, of the corporation
resulting from such Business Combination (including, without limitation, a
corporation which as a result of such transaction owns the Company or all or
substantially all of the Company's assets either directly or through one or more
subsidiaries), (B) no Person (excluding (1) any one ore more Series B
Purchasers, (2) any corporation resulting from such Business Combination, or (3)
any employee benefit plan (or related trust) of the Company or such corporation
resulting from such Business Combination) beneficially owns, directly or
indirectly, 50% or more of, respectively, the then outstanding shares of common
stock of the corporation resulting from such Business Combination or the
combined voting power of the then outstanding voting securities of such
corporation except to the extent that such ownership existed prior to the
Business Combination and (C) at least a majority of the members of the board of
directors of the corporation resulting from such Business Combination were
members of the incumbent board of the Company at the time of the execution of
the initial agreement, or of the action of the Board, providing for such
Business Combination; or

                                      -4-
<PAGE>

               (iii) Approval by the shareholders of the Company of a complete
liquidation or dissolution of the Company.

     6.  Compensation and Fringe Benefits
         --------------------------------

         (a) The Company shall, during the Term of Employment, pay to the
Executive as compensation for the performance of his duties and obligations
hereunder a salary at the rate of no less than Five Hundred Thousand Dollars
($500,000) per annum, which amount shall be reviewed annually on the date
hereof. The compensation payable pursuant to this Section 4(a) shall be payable
in equal biweekly installments on the last day of each such pay period.
Executive's salary shall be increased each year by at least an amount equal to
the percentage increase in the Consumer Price Index for all Urban Wage Earners
in the Seattle-Tacoma area.  In addition to the annual salary, the Executive
will be eligible for an annual performance bonus applicable to executive
personnel of the Company and as agreed by the Compensation Committee of the
Board of Directors of the Company.

         (b) The Executive shall be enrolled and participate in any retirement,
group insurance and other fringe benefit plans and arrangements which are
applicable to the executive personnel of the Company and in effect from time to
time, if he is eligible therefore, in each case in accordance with and subject
to the provisions thereof.  Without limiting the generality of the foregoing,
the Company shall provide Executive with the following benefits:

             (i)     The use of an automobile of Executive's choice which
generally is offered for retail sale at a cost not to exceed $60,000 (not
including taxes and license fees). The Company shall be responsible for all
costs associated with operating such automobile, including, but not limited to
insurance, repairs and maintenance, taxes, license fees and gasoline. Such
automobile shall be replaced with a comparable automobile after four years or
60,000 miles, whichever occurs first. Subject to the terms of any applicable
auto lease, Executive shall have the right to purchase such automobile from the
company upon termination of Executive's employment for a price equal to the
depreciated book value of such automobile;

             (ii)    Reimbursement for the cost of telephone, telefax, and
cellular phone charges, and the acquisition of telephone service and telephone
calls;

             (iii)   A family membership in the Washington Athletic Club,
Seattle, Washington, including monthly dues, up to an annual maximum of $5,000;

             (iv)    Reimbursement for expenses incurred for financial planning
and tax preparation and advice up to a maximum of $25,000;

             (v)     Five (5) weeks of vacation annually;

                                      -5-
<PAGE>

               (vi)   Term life insurance in the amount of $500,000 payable to
beneficiary of Executives choice;

               (vii)  Medical and dental benefits no less favorable than those
offered to other senior executives of the Company as they may be changed from
time to time; and

               (viii) Annual medical check-up.

     7.   Equity-Based Compensation.
          -------------------------

          (a)  Executive has been granted a ten-year stock option under the
Company's Amended and Restated 2000 Stock Incentive Plan, dated August 23, 2000,
which allows Executive to purchase 200,000 shares of the Company's common stock.

          (b)  Executive shall be eligible to receive future grants of stock
options pursuant to the Company's stock-based bonus program consistent with
awards granted to other senior executives of the Company as determined in the
sole discretion of the Compensation Committee of the Board of Directors.

          (c)  If Executive leaves the Company before it becomes a public
company, the Company will not exercise its repurchase rights, under Section 13.1
of the Amended and Restated 2000 Stock Incentive Plan (the "Plan"), to buy back
shares of common stock issued to the Executive pursuant to any awards which were
vested at the time of termination.  Except as otherwise provided in Section
5(e), all unvested awards under the Plan shall immediately expire on any
termination of the Executive's employment for any reason.

     8.   Expenses.  All reasonable and necessary travel and other reasonable
          --------
expenses incident to the rendering of services by the Executive hereunder will
be paid by the Company subject to Company policy.  If such expenses are paid in
the first instance by the Executive, the Company will reimburse him therefor on
presentation of proper expense accounts.

     9.   Noncompetition; Non-Raid.
          ------------------------

          (a)  For a period of one year from the date he ceases to be an
employee of the Company for any reason, the Executive shall not, unless released
from such prohibition by the Company Board of Directors (and consistent with
such conditions as the Board of Directors may impose on any such release),
within North America, Western Europe (as defined in Exhibit A attached hereto)
or Japan, directly or indirectly, be employed by, own, manage, operate, join,
control or participate in the ownership, management, operation or control of or
be connected with in any manner:

               (i)    Any business, whose commercial or research and development
efforts are in competition with the products manufactured or marketed by the
Company, or the Company's products manufactured or marketed by its co-marketing,
co-promotion,

                                      -6-
<PAGE>

licensing or joint venture partners during Executive's employment with the
Company or the products or projects under research or development by the Company
during Executive's employment with the Company (and on which the Company has
expended at least $500,000); or

               (ii) Any research institution whose research efforts are in
competition with products then manufactured or marketed by the Company, or the
Company's products manufactured or marketed by its co-marketing, co-promotion,
licensing or joint venture partners during Executive's employment with the
Company or under research or development by the Company during Executive's
employment with the Company (and on which the Company has expended at least
$500,000), unless the Executive is not involved in any manner in the design,
conduct or supervision of such research efforts, or unless such research is
being conducted solely for scientific and not for commercial purposes. The
executive shall be deemed to be connected with a business if such business is
carried on by partnership in which he is a general or limited partner,
consultant or employee, or a corporation or association of which he is a
shareholder, officer, director, employee, member, consultant or agent; provided,
that nothing herein shall prevent the purchase or ownership by the Executive of
shares of less than 1% of the outstanding shares in a publicly or privately held
corporation.

          (b)  The Executive acknowledges that the covenants set for in Sections
9(a), 9(d) and 9(e) hereof are essential to the Company and that the Company
would not enter into this Agreement if it did not include such covenants.

          (c)  The Executive acknowledges that any violation by him of this
Section 9 will cause the Company irreparable harm.  Therefore, the Executive
agrees that the Company shall be entitled, in addition to any remedies it may
have under this Agreement or at law, to injunctive and other equitable relief to
prevent any breach of this Section 9 by the Executive.

          (d)  During the Term of Employment and for a period of two (2) years
after the employment of the Executive is terminated for any reason, he will not
directly or indirectly, either for his account or as representative agent for
any other person, firm or corporation, solicit the services of, or entice away,
any employee of the Company, or the employee of any company affiliated with the
Company.

          (e)  During the Term of Employment and for a period of two (2) years
after termination of Executive's employment for any reason, Executive shall not,
directly or indirectly, recruit, solicit or induce any advisor, consultant,
customer or business partner of the Company to terminate such party's
relationship with the Company or to engage in activities competitive with the
Company.

     10.  No Duty to Mitigate.  After a termination of employment, Executive
          -------------------
will not be obligated to mitigate his damages by seeking other comparable
employment, and any

                                      -7-
<PAGE>

severance benefits payable to Executive will not be subject to reduction for any
compensation received from other employment.

     11.  Fees and Expenses.  The Company will pay all reasonable professional
          -----------------
fees and related expenses incurred by Executive in connection with the
preparation of this Agreement, not to exceed $10,000.

     The Company will be required to have any successor to all or substantially
all of its business and/or assets expressly assume and agree to perform this
Agreement in the same manner and to the same extent that the Company would be
required to perform if no such succession had taken place.

     12.  Taxes.  The Company may deduct and withhold from any payments to be
          -----
made to Executive hereunder any amounts required to be deducted and withheld by
the Company under the provisions of any statute, law, regulation or ordinance
now or hereafter enacted.  Executive will work reasonably with the Company to
structure any salary, bonus or other compensation in such a fashion to qualify
for tax deductibility under Section 162(m) of the Internal Revenue Code while
preserving the economic benefit intended to be received by Executive.

     13.  Indemnification.  Except to the extent inconsistent with the Company's
          ---------------
Certification of Corporation or Bylaws, the Company will indemnity and hold
harmless Executive to the fullest extent permitted by law with respect to
Executive's service as an officer and director of the Company.

     14.  Governing Law.  This Agreement shall be governed by and construed in
          -------------
accordance win the laws of the State of Washington.

     15.  Entire Agreement.  This Agreement and the Employee Inventions and
          ----------------
Proprietary Information Agreement, dated November 9, 2000, sets forth the entire
agreement and understanding between Executive and the Company and supersedes and
cancels any prior understanding, agreements or representations by or between the
parties and between the Executive and Novo Nordisk A/S, written or oral
including, without limitation, the Services Agreement between the Company and
the Executive, dated September 5, 1997, in its entirety.  This Agreement may not
be amended, modified, changed or discharged in any respect except as agreed in
writing signed by the parties.

     16.  No Conflict.  Executive represents and warrants that this Agreement
          -----------
and his performance hereunder does not and will not breach or conflict with any
agreement to which Executive is or becomes a party.

     17.  Successors and Assigns.  The services and duties to be performed by
          ----------------------
Executive hereunder are personal and may not be assigned.  This Agreement shall
be binding upon and inure to the benefit of the Company, its successors and
assigns and Executive, his heirs and representatives.

                                      -8-
<PAGE>

     18.  Waiver.  Failure by either party to insist upon strict adherence to
          ------
any one or more of the provisions of this Agreement on one or more occasions
shall not be construed as a waiver, nor shall it deprive that party of the right
to require strict compliance thereafter.

     19.  Severability.  Whenever possible, such provision of this Agreement
          ------------
shall be interpreted in such manner as to be effective and valid under
applicable law.  If any provision of this Agreement is held to be invalid,
illegal or unenforceable in any respect under any applicable law in any
jurisdiction, such invalidity, illegality or unenforceability will not effect
any other provision or the interpretation of this Agreement in any other
jurisdiction.

     20.  Notices.  Any notice required or desired to be given hereunder shall
          -------
be in writing and shall be deemed sufficiently given when delivered or when
mailed by first class certified or registered mail, postage prepaid, to the
party for whom intended at the following address:

     The Company

          Chairman of the Board
          Zymo Genetics, Inc.
          1201 Eastlake Avenue East
          Seattle, Washington  98102

     With a Copy to:

          James Lisbakken, Esq.
          Perkins Coie LLP
          1201 Third Avenue, 48th Floor
          Seattle, Washington  98101-3099

     The Executive

          Dr. Bruce L.A. Carter
          1642 Federal Avenue East
          Seattle, Washington 98120

or to such other address, as to either party, as such party shall from time to
time designate by like notice to the other.

     21   Counterparts.  This Agreement may be executed in two or more
          ------------
counterparts, of like tenor and effect, each of which shall be deemed an
original but all of which together shall constitute one and the same
instruments.

                                      -9-
<PAGE>

     IN WITNESS THEREOF, the parties hereto have executed this Agreement as of
the first date written above.

                              ZYMOGENETICS, INC.

                              By: /s/ Shinko Campos
                                  --------------------------------------------
                                  Its:  Chief Business and Operations Officer
                                      ----------------------------------------

                              /s/ Bruce L.A. Carter
                              ------------------------------------------------
                              Bruce L.A. Carter

                                      -10-

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