Document:

EX-4.2

 Exhibit 4.2 

THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE
SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. INVESTORS SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN
OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 

G1 THERAPEUTICS, INC. 
 WARRANT TO
PURCHASE STOCK 
  

					
	Warrant No.    	 		  	Issued on                     
		 		  	Void after                     

 This certifies that in consideration of sums previously paid to G1 Therapeutics, Inc., a Delaware corporation
(the “Company”), receipt of which is hereby acknowledged, [                    ] is entitled, subject to the terms and conditions of
this Warrant, to purchase from the Company at any time after the issuance hereof and prior to 5:00 p.m. Pacific time on [            ,         ] (the
“Expiration Date”), up to [                ] shares of Common Stock of the Company (the “Warrant Stock”) for an exercise price of
$[        ] per share (the “Warrant Price”), upon surrender of this Warrant at the principal offices of the Company, together with a duly executed subscription form in the form attached hereto
as Exhibit 1 and, unless this Warrant is exercised pursuant to Section 2.6 below, simultaneous payment of the full Warrant Price for the shares of Warrant Stock so purchased in lawful money of the United States. The Warrant Price and the
number and character of shares of Warrant Stock are subject to adjustment as provided herein and the term “Warrant Stock” shall include stock and other securities and property at any time receivable or issuable upon exercise of this
Warrant in accordance with its terms. 
 1. DEFINITIONS. The following definitions shall apply for purposes
hereof. 
 1.1 “Acquisition” means: (a) any sale or exchange of the capital stock by the shareholders of the
Company in one transaction or series of related transactions where more than 50% of the outstanding voting power of the Company is acquired by a person or entity or group of related persons or entities; or (b) immediately prior to any
reorganization, consolidation or merger of the Company where the outstanding voting securities of the Company immediately before the transaction represent or are converted into less than fifty percent 50% of the outstanding voting power of the
surviving entity (or its parent corporation) immediately after the transaction; or (c) the consummation of any transaction or series of related transactions that results in the sale of all or substantially all of the assets of the Company,
followed by the distribution of the proceeds to the Company’s shareholders. 
 1.2 “Company” means the
“Company” as defined above and includes any corporation which shall succeed to or assume the obligations of the Company under this Warrant. 

1.3 “Holder” means any person who shall at the time be the registered holder of this Warrant. 

1.4 “Warrant” means this Warrant and any warrant(s) delivered in substitution or exchange therefor, as provided herein.

 2. EXERCISE. 

2.1 Method of Exercise. Subject to the terms and conditions of this Warrant, the Holder may exercise this Warrant in whole or in
part, at any time or from time to time, on any business day before the Expiration Date by surrendering this Warrant at the principal offices of the Company, with the subscription form attached hereto duly executed by the Holder, and by payment of an
amount equal to the product obtained by multiplying the number of shares of Warrant Stock to be purchased by the Holder by the Warrant Price or adjusted Warrant Price therefor, if applicable, as determined in accordance with the terms hereof. 

2.2 Form of Payment. Payment may be made by (a) a check payable to the Company’s order, (b) wire transfer of
funds to the Company, (c) cancellation of indebtedness of the Company to the Holder or (d) any combination of the foregoing. 

2.3 Partial Exercise. Upon a partial exercise of this Warrant: (a) the number of shares of Warrant Stock immediately prior
to such exercise shall be reduced by the aggregate number of shares so acquired upon such exercise of this Warrant, and (b) this Warrant shall be surrendered by the Holder and replaced with a new Warrant of like tenor representing the right to
purchase the shares of Warrant Stock that remain yet to be purchased. 
 2.4 No Fractional Shares. No fractional shares may be
issued upon any exercise of this Warrant, and any fractions shall be rounded down to the nearest whole number of shares. If upon any exercise of this Warrant a fraction of a share results, the Company will pay the cash value of any such fractional
share, calculated on the basis of the Warrant Price. 
 2.5 Restrictions on Exercise. This Warrant may not be exercised if the
issuance of the Warrant Stock upon such exercise would constitute a violation of any applicable federal or state securities laws or other laws or regulations. As a condition to the exercise of this Warrant, the Holder shall execute the subscription
form attached hereto as Exhibit 1, confirming and acknowledging that the representations and warranties of the Holder set forth in Section 6 hereof are true and complete as of the date of exercise. 

2.6 Net Exercise Election. The Holder may elect to convert all but not less than all of this Warrant, without the payment by the
Holder of any additional consideration, by the surrender of this Warrant to the Company, with the net exercise election selected in the subscription form attached hereto duly executed by the Holder, into the number of shares of Warrant Stock that is
obtained under the following formula: 
  

			
	 X = Y (A-B)

A

		
	Where:	  	X = the number of shares of Warrant Stock to be issued to the Holder pursuant to this Section 2.6.
		
		  	Y = the number of shares of Warrant Stock as to which this Warrant remains unexercised.

			
		  	A = the fair market value of one share of Warrant Stock, as determined in good faith by the Company’s Board of Directors, as at the time the net exercise election is made pursuant to this Section 2.6.
		
		  	B = the Warrant Price.

 The Company will promptly respond in writing to an inquiry by the Holder as to the then current fair market value of one share
of Warrant Stock. For purposes of the above calculation, fair market value of one Share shall be determined by the Company’s Board of Directors in good faith; provided, however, that where there exists a public market for the Company’s
Common Stock at the time of such exercise, the fair market value per share shall be the product of (a) the average of the closing bid and asked prices of the Common Stock quoted in the Over-The-Counter Market Summary or the last reported sale
price of the Common Stock or the closing price quoted on the Nasdaq Global Market or on any exchange on which the Common Stock is listed, whichever is applicable, as published in the Western Edition of The Wall Street Journal for the five
trading days prior to the date of determination of fair market value and (b) the number of shares of Common Stock into which each Share is convertible, if applicable, at the time of such exercise. Notwithstanding the foregoing, in the event the
Warrant is exercised in connection with the Company’s initial public offering of Common Stock, the fair market value per share shall be the product of (i) the per share offering price to the public of the Company’s initial public
offering, and (ii) the number of shares of Common Stock into which each Share is convertible, if applicable, at the time of such exercise. 

3. ISSUANCE OF STOCK. Except as set forth in Section 4, this Warrant shall be deemed to have been exercised
immediately prior to the close of business on the date of its surrender for exercise as provided above, and the person entitled to receive the shares of Warrant Stock issuable upon such exercise shall be treated for all purposes as the holder of
record of such shares as of the close of business on such date. As soon as practicable on or after such date, the Company shall issue and deliver to the person or persons entitled to receive the same a certificate or certificates for the number of
whole shares of Warrant Stock issuable upon such exercise. 
 4. EARLY EXPIRATION OR ASSUMPTION. 

4.1 Assumption of Warrant. Upon the closing of any Acquisition where the consideration for the Acquisition to be received by the
Company’s stockholders consists solely of stock or securities of the acquirer or an entity affiliated with the acquirer, the successor entity shall assume the obligations of this Warrant, and this Warrant shall be exercisable for the same
securities as would be payable for the Shares issuable upon exercise of the unexercised portion of this Warrant as if such Shares were outstanding on the record date for the Acquisition and subsequent closing. The Warrant Price shall be adjusted
accordingly. 
 4.2 Termination of Warrant. In the case of (a) an Acquisition where the consideration for the Acquisition
to be received by the Company’s stockholders in return for their capital stock of the Company consists of cash or a combination of cash and other property or (b) the proposed liquidation and dissolution of the Company, the Company shall
give Holder at least 20 days advance written notice of such event (the “Company Notice”), which notice shall include the Company’s best estimate of the value of the Shares receivable upon exercise or conversion of this Warrant
and the proposed date upon which such event is expected to occur. During such notice period, Holder may exercise or convert this Warrant in accordance with its terms, whether or not exercise or conversion is contingent upon the happening of such
event an/or existence of a minimum value of the Shares receivable upon exercise or conversion as provided on Holder’s exercise notice; provided that such minimum value shall be no greater

 
than the per share price set forth in the Company Notice. Subject to prior exercise or conversion as provided in the preceding sentence, this Warrant will terminate at 5:00 p.m. Pacific time on
the day prior to the date such event is expected to occur as set forth in the Company Notice; provided that (a) the Company Notice of the proposed event is actually received by Holder, as evidenced by a return receipt of certified mail
delivery, a certificate of delivery by hand delivery or written verification of delivery from the overnight courier, or is waived by the Holders of the Warrants, and (b) the event actually occurs within 60 days after the date it is expected to
occur, as such date was specified in the Company Notice. 
 5. ADJUSTMENTS TO THE SHARES. 

5.1 Stock Dividends, Splits, Etc. If the Company declares or pays a dividend on the Warrant Stock payable in Warrant Stock or
other securities of the Company or subdivides the Warrant Stock in a transaction that increases the amount of Warrant Stock into which this Warrant may be exercised, or if the Company combines the Warrant Stock in a transaction that decreases the
amount of Warrant Stock into which this Warrant may be exercised, then upon exercise of this Warrant, for each share of Warrant Stock acquired, Holder shall receive, without cost to Holder, the total number and kind of securities to which Holder
would have been entitled had Holder owned the Warrant Stock of record as of the date the dividend, subdivision or combination occurred, unless the conversion ratio of such Warrant Stock already reflects such event. 

5.2 Reclassification, Exchange or Substitution. Unless the conversion ratio of the Warrant Stock already reflects such event,
upon any reclassification, exchange, substitution, or other event that results in a change of the number and/or class of the securities issuable upon conversion of this Note (other than a transaction described in Section 5.1 above), Holder
shall be entitled to receive, upon exercise of this Warrant, the number and kind of securities and property that Holder would have received for the Warrant Stock if this Warrant had been exercised immediately before such reclassification, exchange,
substitution or other event. By way of example, such an event shall include any automatic conversion of the outstanding or issuable securities of the Company of the same class or series as the Warrant Stock to Common Stock pursuant to the terms of
the Company’s Certificate of Incorporation upon the closing of a registered public offering of the Company’s Common Stock. The Company or its successor shall promptly issue to Holder a new Warrant for such new securities or other property.
The new Warrant shall provide for adjustments that shall be as nearly equivalent as may be practicable to the adjustments provided for in this Section 5 including, without limitation, appropriate adjustments to the Warrant Price and to the
number of securities or property issuable upon exercise of the new Warrant. 
 5.3 Adjustments of Warrant Price. Unless the
conversion ratio of the Warrant Stock already reflects such event: (a) if the outstanding shares of Warrant Stock are combined or consolidated, by reclassification or otherwise, into a lesser number of shares of Warrant Stock, the Warrant Price
shall be proportionately increased; and (b) if the outstanding shares of Warrant Stock are divided by reclassification or otherwise, into a greater number of shares of Warrant Stock, the Warrant Price shall be proportionately decreased. 

5.4 Adjustments Cumulative. The provisions of this Section 5 shall similarly apply to successive stock dividends, stock
splits or combinations, reclassifications, exchanges, substitutions, or other events. 
 5.5 No Impairment. The Company shall
not, by amendment of its Certificate of Incorporation or through a reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any other voluntary action, avoid or seek to avoid the observance or
performance of 

 
any of the terms to be observed or performed under this Warrant by the Company, but shall at all times in good faith assist in carrying out of all the provisions of this Section 5 and in
taking all such action as may be necessary or appropriate to protect Holder’s rights under this Section against impairment. 
 5.6
Fractional Warrant Stock. No fractional share of Warrant Stock shall be issuable upon exercise of this Warrant and the number of shares of Warrant Stock to be issued shall be rounded down to the nearest whole share. If a fractional share
interest arises upon any exercise of this Warrant, the Company shall eliminate such fractional share interest by paying Holder an amount by check computed by multiplying the fractional interest by the fair market value of a full share. 

5.7 Certificate as to Adjustments. Upon each adjustment of the Warrant Price and no later than 30 days after the event causing
the adjustment has occurred, the Company, at its expense, shall promptly compute such adjustment, and furnish Holder with a certificate of its Chief Financial Officer setting forth such adjustment and the facts upon which such adjustment is based.
The Company shall, upon written request, furnish Holder a certificate setting forth the Warrant Price in effect upon the date thereof and the series of adjustments leading to such Warrant Price. 

5.8 No Change Necessary. The form of this Warrant need not be changed because of any adjustment in the Warrant Price or in the
number of shares of Warrant Stock issuable upon its conversion. 
 5.9 Reservation of Stock. If at any time the number of
shares of Warrant Stock or other securities issuable upon exercise of this Warrant shall not be sufficient to effect the exercise of this Warrant, the Company will use reasonable, diligent efforts to take such corporate action as may, in the opinion
of its counsel, be necessary to increase its authorized but unissued shares of Warrant Stock or other securities issuable upon exercise of this Warrant as shall be sufficient for such purpose. 

6. INVESTMENT REPRESENTATIONS. 

6.1 Purchase for Own Account. This Warrant and the Warrant Stock (collectively, the “Securities”) are acquired
for investment for Holder’s own account, not as a nominee or agent, and not with a view to the public resale or distribution thereof within the meaning of the Securities Act, and Holder has no present intention of selling, granting any
participation in, or otherwise distributing the same. 
 6.2 No Solicitation. At no time was Holder presented with or
solicited by any publicly issued or circulated newspaper, mail, radio, television or other form of general advertising or solicitation in connection with the offer, sale and purchase of the Securities. 

6.3 Disclosure of Information. Holder has received or has had full access to all the information Holder considers necessary or
appropriate to make an informed investment decision with respect to the Securities. Holder further has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of the Securities and
to obtain additional information (to the extent the Company possessed such information or could acquire it without unreasonable effort or expense) necessary to verify any information furnished to Holder or to which Holder had access. 

 6.4 Investment Experience. Holder understands that the purchase of the Securities
involves substantial risk. Please check the correct response(s) below. 
  ̈ Holder has
experience as an investor in securities of companies in the development stage and acknowledges that Holder is able to fend for him, her or its self, can bear the economic risk of Holder’s investment in the Securities and has such knowledge and
experience in financial or business matters that Holder is capable of evaluating the merits and risks of this investment in the Securities and protecting Holder’s own interests in connection with this investment in the Securities. 

 ̈ Holder has a preexisting personal or business relationship with the Company and certain of
its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the character, business acumen and financial circumstances of such persons. 

 ̈ Holder is familiar with the definition of, and qualifies as, an “accredited
investor” within the meaning of Regulation D promulgated under the Securities Act because Holder meets one of the following requirements: (a) Holder is a natural person whose individual net worth, or joint net worth with that person’s
spouse, at the time of his or her purchase exceeds $1,000,000, (b) Holder is a natural person who had an individual income in excess of $200,000 in each of the two most recent years or joint income with that person’s spouse in excess of
$300,000 in each of those two years and has a reasonable expectation of reaching the same income level in the current year or (c) Holder is a corporation, limited liability company or partnership having total assets in excess of $5,000,000 that
was not formed for the purpose of investing in the Company or (d) by reason of the following. 
 6.5 Restricted
Securities. Holder understands that the Securities are characterized as “restricted securities” under the Securities Act and Rule 144 promulgated thereunder (“Rule 144”) since they are being acquired
from the Company in a transaction not involving a public offering, and that under the Securities Act and applicable regulations thereunder the Securities may be resold without registration under the Securities Act only in certain limited
circumstances. Holder further understands that the Company is under no obligation to register the Securities, and the Company has no present plans to do so. Furthermore, Holder is familiar with Rule 144, as presently in effect, and understands the
limitations imposed thereby and by the Securities Act on resale of the Securities without such registration. Holder understands that, whether or not the Securities may be resold in the future without registration under the Securities Act, no public
market now exists for any of the Securities and that it is uncertain whether a public market will ever exist for the Securities. 
 7.
RESTRICTIONS UPON TRANSFER. 
 7.1 Market Standoff. Holder agrees in connection with any registration of the
Company’s securities that, upon the request of the Company or the underwriters managing any public offering of the Company’s securities, Holder will not sell or otherwise dispose of any Shares without the prior written consent of the
Company or such underwriters, as the case may be, for such period of time (not to exceed one hundred eighty (180) days) after the effective date of such registration requested by such underwriters and subject to all restrictions as the Company
or the underwriters may specify. Further, if during the last seventeen (17) days of the restricted period the Company issues an earnings release or material news or a material event relating to the Company occurs, or prior to the expiration of
the restricted period the Company announces that it will release earnings results during the 16-day period beginning on the last day of the restricted period, then if required by the underwriters or the Company the restrictions imposed by
this Section shall continue to apply until the expiration of the 18-day period beginning on the issuance of the earnings release or the occurrence of the material news or material event. In no event will the restricted period extend beyond two
hundred fifteen (215) days after the effective date of the registration statement. Holder further agrees to enter into any agreement reasonably required by the underwriters to implement the foregoing. 

 7.2 Further Limitations on Disposition. Without in any way limiting the
representations set forth above, Holder further agrees not to make any disposition of all or any portion of the Securities unless and until: 

(a) there is then in effect a registration statement under the Securities Act covering such proposed disposition and such
disposition is made in accordance with such effective registration statement; or 
 (b) Holder shall have notified the
Company of the proposed disposition and shall have furnished the Company with a statement of the circumstances surrounding the proposed disposition and, at the expense of Holder or its transferee, with an opinion of counsel reasonably satisfactory
in form and substance to the Company that such disposition will not require registration of such Securities under the Securities Act or under the blue sky laws of any State of the United States. 

7.3 Legends. Holder understands and agrees that the certificates evidencing the Securities will bear legends substantially
similar to those set forth below in addition to any other legend that may be required by applicable law, the Company’s Certificate of Incorporation or Bylaws, this Agreement or any other agreement between the Company and Holder: 

(a) THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR UNDER THE SECURITIES LAWS OF APPLICABLE STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES
LAWS, PURSUANT TO REGISTRATION UNDER SUCH LAWS OR AN EXEMPTION FROM SUCH REGISTRATION REQUIREMENT. INVESTORS SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE ISSUER OF
THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE WITH THE ACT AND ALL APPLICABLE STATE SECURITIES LAWS. 

(b) THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A MARKET STAND-OFF RESTRICTION AS SET FORTH IN A CERTAIN
AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THESE SHARES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE ISSUER. AS A RESULT OF SUCH AGREEMENT, THESE SHARES MAY NOT BE TRADED DURING A SPECIFIED PERIOD AFTER THE EFFECTIVE
DATE OF ANY PUBLIC OFFERING OF THE COMMON STOCK OF THE ISSUER HEREOF. SUCH RESTRICTION IS BINDING ON TRANSFEREES OF THESE SHARES. 

(c) Any legend required by the laws of the State of the Company’s formation, or any state securities laws. 

The legend set forth in (a) above shall be removed by the Company from any certificate evidencing the Securities upon delivery to the Company of an
opinion of counsel, reasonably satisfactory in form and substance to the Company, that either (i) a registration under the Securities Act and applicable state securities laws is at that time in effect with respect to the legended security or
(ii) such security can be freely transferred in a public sale (other than pursuant to Rule 144, Rule 144A or Rule 145 promulgated under the Securities Act) without such registrations being in effect and that such transfer will not jeopardize
the exemption or exemptions from registration pursuant to which the Company issued the Securities. 

 8. NO RIGHTS OR LIABILITIES AS SHAREHOLDER. This Warrant does not by itself entitle
the Holder to any voting rights or other rights as a shareholder of the Company. In the absence of affirmative action by the Holder to purchase Warrant Stock by exercise of this Warrant, no provisions of this Warrant, and no enumeration herein of
the rights or privileges of the Holder, shall cause the Holder to be a shareholder of the Company for any purpose. 
 9. GENERAL
PROVISIONS. 
 9.1 Attorneys’ Fees. In the event any party is required to engage the services of any
attorneys for the purpose of enforcing this Warrant, or any provision thereof, the prevailing party shall be entitled to recover its reasonable expenses and costs in enforcing this Warrant, including attorneys’ fees. 

9.2 Transfer. Neither this Warrant nor any rights hereunder may be assigned, conveyed or transferred, in whole or in part,
without the Company’s prior written consent, which the Company may withhold in its sole discretion. The rights and obligations of the Company and the Holder under this Warrant shall be binding upon and benefit their respective permitted
successors, assigns, heirs, administrators and transferees. 
 9.3 Governing Law. This Warrant shall be governed by and
construed under the internal laws of the state of Washington as applied to agreements among Washington residents entered into and to be performed entirely within Washington, without reference to principles of conflict of laws or choice of laws. 

9.4 Headings. The headings and captions used in this Warrant are used only for convenience and are not to be considered in
construing or interpreting this Warrant. All references in this Warrant to sections and exhibits shall, unless otherwise provided, refer to sections hereof and exhibits attached hereto, all of which exhibits are incorporated herein by this
reference. 
 9.5 Notices. Unless otherwise provided, any notice required or permitted under this Warrant shall be
given in writing and shall be deemed effectively given: (a) at the time of personal delivery, if delivery is in person; (b) one business day after deposit with an express overnight courier for United States deliveries, or two business days
after such deposit for deliveries outside of the United States, with proof of delivery from the courier requested; or (c) three business days after deposit in the United States mail by certified mail (return receipt requested) for United States
deliveries when addressed to the Holder to be notified at Holder’s address at Fenwick & West LLP 1191 Second Avenue, 10th Floor, Seattle, Washington 98101 Attn: Alan Smith or, in the
case of the Company, at G-Zero Therapeutics, Inc., 450 West Drive, Chapel Hill, North Carolina 27599-7295, Attn: President, or at such other address as any party may designate by giving 10 days’ advance written notice to the other party hereto.

 9.6 Amendment; Waiver. Any term of the Warrants may be amended and the observance of any term of the Warrants may be
waived (either generally or in a particular instance and either retroactively or prospectively), with the written consent of the Company and the Holder of record hereof. 

9.7 Severability. If one or more provisions of this Warrant are held to be unenforceable under applicable law, such
provision(s) shall be excluded from this Warrant and the balance of the Warrant shall be interpreted as if such provision(s) were so excluded and shall be enforceable in accordance with its terms. 

 9.8 Terms Binding. By acceptance of this Warrant, the Holder accepts and agrees to
be bound by all the terms and conditions of this Warrant. 
 [signature page follows] 

 In Witness Whereof, the parties hereto have executed this Warrant to Purchase Stock as of
the date first written above. 
  

			
	G-1 THERAPEUTICS, INC.:
		
	By:	 	  

	Name:	 	
	Title:	 	

  

			
	THE HOLDER:
		
	By:	 	  

	Name:	 	  

	Title:	 	  

 EXHIBIT 1 

FORM OF SUBSCRIPTION 

(To be signed only upon exercise of Warrant) 

To: G-Zero Therapeutics, Inc. or Successor 

(1) Cash Exercise Election. The undersigned Holder hereby elects to
purchase                 shares of Common Stock of G1 Therapeutics, Inc. (the “Warrant Stock”), pursuant to the terms of the attached Warrant,
and tenders herewith payment of the purchase price for such shares in full. This exercise             [is]             [is not]
contingent upon the closing of the Acquisition or other event specified in the Company Notice to Holder in accordance with Section 4 of the Warrant received by Holder
on                     and            
[is]             [is not] contingent upon a sale price or fair market value for the Company’s Warrant Stock in the Acquisition or other event of no less than the lesser of
(a)                 per share or (b) the per share price set forth in the Company Notice. 

(1) Net Exercise Election. The undersigned Holder elects to convert the Warrant into shares of Warrant Stock by net exercise
election pursuant to Section 2.6 of the Warrant. This conversion is exercised with respect to                 shares of Common Stock of G1 Therapeutics, Inc. (the
“Warrant Stock”) covered by the Warrant. This exercise             [is]             [is not] contingent
upon the closing of the Acquisition or other event specified in the Company Notice to Holder in accordance with Section 4 of the Warrant received by Holder
on                     and            
[is]             [is not] contingent upon a sale price or fair market value for the Company’s Warrant Stock in the Acquisition or other event of no less than the lesser of
(a) $         per share or (b) the per share price set forth in the Company Notice. 

[STRIKE PARAGRAPH ABOVE THAT DOES NOT APPLY] 

(2) In exercising the Warrant, the undersigned Holder hereby confirms and acknowledges that the representations and warranties set
forth in Section 6 of the Warrant as they apply to the undersigned Holder continue to be true and complete as of this date. 

(3) Please issue a certificate or certificates representing said Shares in the name of the undersigned Holder. 

 

							
	Date:	 	  
	 		 	  

		 		 		 	(Name)
				
		 		 		 	  

		 		 		 	  

		 		 		 	  

		 		 		 	Address
				
		 		 		 	  

		 		 		 	(Signature of Holder)
				
		 		 		 	  

		 		 		 	(Tax Identification Number)EX-4.3

 Exhibit 4.3 

THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR
HYPOTHECATED TAI THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO SUCH SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 

 
  

STOCK WARRANT 
  

			
	Issue Date:                     	  	Expiration Date:                     

 THIS CERTIFIES that, for value received,
                                         (the
“Holder”) is entitled to subscribe for and purchase from G-Zero Therapeutics, Inc. (the “Company”)
                 shares of the company’s common stock (the “Common Stock”), subject to adjustment, as set forth herein, at a price per share of $0.01 (the
“Exercise Price”), subject to adjustment as set forthherein. 
 Section 1. Method of Exercise and Expiration.

 1.1 Term and Expiration. Subject to the terms and conditions set forth in this Warrant, this Warrant may be exercised in whole or in part at
any lime and from time to time from the date hereof through the Expiration Date (the “Exercise Period”), If this Warrant is exercised in part front time to time during the Exercise Period, it shall be exercised hi minimum quantities of
Shares equal to 100 shares (or such lesser number of shares which may then constitute the maximum number purchasable; such number being subject to adjustment as set forth herein). 

1.2 Deliverables by the Holder Upon Exercise. This Warrant shall be exercised by delivery of the following to the Company at the address of the Company
in the Holder’s records, Attention: President / CEO (or at such other agency or office of the Company as it may designate by notice in writing to the Holder at the Fatless of the Holder appearing in the books of the Company); 

(a) an executed Notice of Exercise in the form attached hereto as Exhibit A; 

(b) payment of the Exercise Price for the aggregate amount of Shares being purchased (i) in cash or by cashier’s check, (ii) by
cancellation by the Holder of indebtedness or other obligations of the Company to the Holder, (iii) by a combination of (i) and (ii), or (iv) pursuant to Section 1.4 below; and 

(c) this Warrant. 
 1.3 Deliverables by the
Company Upon Exercise. In the event of any exercise of the rights represented by this Warrant, a certificate or certificates for the Shares so purchased, registered in the name of the person or entity entitled to receive the same, shall be
delivered to the Holder within thirty (30) days (or such later time agreed to in writing by the Holder) after the rights represented by this Warrant shall have been so exercised; provided, that if the Company does not customarily issue share
certificates, an appropriate and binding entry in the stock ledger of the 

  
 Page 1 of 9 

 
Company may be made in lieu of the certificates called for by this Section 1.3 and the Company shall deliver to the Holder a copy of such stock ledger certified by an appropriate officer of
the Company. Unless this Warrant has expired or been fully exercised, a new warrant representing the Shares, if any, with respect to which this Warrant shall not then have been exercised shall also be issued to the Holder within such time,
containing the same terms and conditions specified herein. The person or entity in whose name any certificate or certificates for Shares arc to be issued upon exercise of this Warrant shall for all purposes be deemed to have become the holder of
record of such Shares on the date on which this Warrant was surrendered and payment of the Exercise Price was made, irrespective of the date of delivery of such certificate or certificates, except that, if the date of such surrender and payment is a
date when the stock transfer books of the Company are closed, such person or entity shall be deemed to have become the holder of record of such Shares at the close of business on the next succeeding date on which the stock transfer hooks are open.

 1.4 Net Issue Exercise. Notwithstanding any provisions herein to the contrary, if the fair market value of one (1) Share is greater than the
Exercise Price (at the date of calculation as set forth below), in lieu of exercising this Warrant for cash, the Holder may elect to receive shares equal to the value (as determined below) of this Warrant (or the portion thereof being exercised)
(such election being referred to herein as a “Net Issue Exercise Election”) by surrender of this Warrant at the principal office of the Company together with the properly endorsed Notice of Exercise and. notice of such election in which
event the Company shall issue to Holder a number of Shares computed using the following formula: 
 X = Y(A-B) 

    A 
  

					
	Where	    	X =	  	the number of Shores to he issued to the Holder.
			
		    	Y =	  	the number of Shares purchasable under this Warrant or, if only a portion of the Warrant is being exercised, the portion of the Warrant being exercised.
			
		    	A	  	the “fair market value” (as defined below) of one (1) Share.
			
		    	B	  	the Exorcise Price per Share (as adjusted to the date of such calculation).

 For purposes of this Section 1.4, the fair market value per Share shall be the product of (i) the average of
the closing bid and asked prices of the Shares quoted in any applicable over the counter market summary or the last reported sale price of the Shares or the average closing price quoted on any exchange on which the Shares are listed, whichever is
applicable, for thirty (30) trading days prior to the date of determination of fair market value and (ii) the number of Shares into which each Share is convertible at the time of such exercise. If the Shares are not traded over the counter
or on an exchange, the fair market value shall be the price per Share which the Company could obtain from a willing buyer for Shares sold by the Company from authorized but unissued shares, as such price shall be agreed in good faith by the Company
and the Holder. If the Company and the Holder are unable to agree on the “fair market value” of the Shares within 

  
 Page 2 of 9 

 
ten (10) days of receipt of the Notice of Exercise required under Section 1.2(a) above, then the fair market value shall be determined by an independent valuation expert selected by the
Company and reasonably acceptable to the Holder. Notwithstanding the foregoing, in the event the Warrant is exercised in connection with the Company’s initial public offering of Shares, the fair market value per Share shall be the product of
(i) the per Share offering price to the public of the Company’s initial public offering, and (ii) the number of Shares into which each Share is convertible at the time of exercise. 

In the event that the Holder makes a Net Issue Exercise Election pursuant to this Section 1.4, the provisions of Section 1.2 regarding certain
delivery obligations of the Holder, and Section 1.3 regarding certain delivery obligations of the Company, shall be fully applicable upon such election, 

Section 2. Representations and Warranties of Company. 

2.1 Organization. The Company is duly organized, validly existing and in good standing under the laws of die jurisdiction in which it is incorporated
and is duly qualified and is in good standing as a foreign Company in those jurisdictions where the conduct of its business or ownership of its property requires qualification. The Company has the corporate power to carry out the business in which
it is engaged. 
 2.2 Valid Obligation. The execution and delivery of this Warrant and any related documents have been duly authorized by all
necessary action of the Board of Directors and shareholders of the Company under applicable law, and are not and will not be in contravention of any provision of law, nor in contravention of any certificate of authority, bylaw or other applicable
corporate documents of the Company, nor result in the breach of any agreement, indenture, or undertaking to which the Company is a party or by which it is bound. 

2.3 Shares. All Shares which may be issued upon the exercise of the rights represented by this Warrant will, upon issuance, be validly issued and
outstanding, fully paid and nonassessable, with no personal liability attaching to the ownership thereof, and free from all taxes, liens and charges with respect to the issuance thereof. 

Section 3. Covenants of Company. 

3.1 Covenants as to Shares. The Company covenants and agrees that the Company shall authorize and reserve a sufficient number of Shares to provide for
all permitted exercises of the rights represented by this Warrant. If at any time the number of authorized but unissued Shares shall not be sufficient to effect any permitted exercise of this Warrant, the Company shall take such corporate action as
may, in the opinion of its counsels be necessary to increase its authorized but unissued Shares to such number of shares as shall be sufficient for such purposes. The Company shall give the Holder at least thirty (30) days prior written notice
of the filing of a registration statement under the Securities Act of 1933, as amended (the “Act”), covering the offering and Rale of the Company’s securities. 

3.2 No Impairment. Except and to the extent waived or consented to by the Holder In writing, the Company will not, by amendment of its charter or
through any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other 

  
 Page 3 of 9 

 
action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but will at all times in good faith assist in the carrying
out of all the provisions in this Warrant and in the taking of all such action as may be necessary or appropriate in order to protect from impairment the rights of the Holder to purchase the Shares hereunder. 

3.3 Notice of Record Date. In the event the Company establishes a record date in order to determine the holders of any class of securities of the
Company as of such record date; (1) for the purpose of determining the holders thereof who are entitled to receive any dividend (other than a cash dividend which is the same as cash dividends paid in the previous two (2) quarters) or any
other distribution as regards any securities of the Company (whether in cash, in securities, or pursuant to any spin-off, split-off or distribution of the Company’s assets); (ii) for the purpose of entitling them to subscribe for or
purchase any shares of any class of securities or to receive any other rights; (iii) for any classification, reclassification, or other reorganization of the securities which the Company is now or hereafter authorized to issue, the
consolidation or merger of the Company with or into another Company, or the conveyance of all or substantially all of the assets of the Company; or (iv) for a voluntary or involuntary dissolution, liquidation or winding up of the Company; then,
the Company shall provide written notice to the Holder, at least thirty (30) days prior to the proposed record date, specifying the record date. 
 3.4
Adjustment Due to Change in Number of Outstanding Shares. In any of the following events (each, a “Triggering Event”), appropriate adjustment shall be made in the minim of Shares which may be purchased by the Holder upon the
exercise of this Warrant or in the Exercise Price per Share to be paid, so as to maintain the proportional interest of the Holder in the ownership, on a fully diluted basis, of the Company, as follows: 

(a) If the Company shall at any time subdivide any class of its equity securities by split-up or otherwise, or combine its outstanding equity
securities, or issue additional shares of its equity securities in payment of a dividend in respect of its equity securities, the number of Shares underlying this. Warrant shall be proportionately increased and the Exercise Price proportionately
decreased in the case of a subdivision or stock dividend, and the number of Shares underlying this Warrant shall he proportionately decreased and the Exercise Price proportionally increased in the case of a combination. 

(b) In case of any reclassification or change of the outstanding equity securities of the Company (other than as a result of a subdivision,
combination or dividend), or in case of any consolidation of the Company with, or merger of the Company into, another company or other business organization (other than a consolidation or merger in which the Company is the continuing Company and
which does not result in any reclassification or change of the outstanding equity securities of the Company or in the issuance of any other securities of the Company), or in the case of any sale or conveyance to another Company or other business
organization of the property of the Company as an entirety or substantially as an entirety, then the Holder or other holder of this Warrant shall have the right to acquire the kind and amount of shares of capital stock and other securities and
property receivable upon such reclassification, change, consolidation, merger, sale or conveyance by a holder of the number of Shares of the Company which might have been acquired by the Holder upon exercise of this Warrant immediately prior to such
reclassification, change, consolidation, merger, sale or conveyance. 

  
 Page 4 of 9 

 (c) If the Company shall, after the date hereof, at any time or from time to time issue, or is
deemed to have been issued (as defined below), any Shares for a purchase price per Share less than the then-current Exercise Price, then the Exercise Price shall immediately be reduced to the price determined using the following formula, on a fully
diluted basis: 
  

			
	X =	  	((AxB) -1- CI
		  	          Y

  

					
	Where	  	X =	  	the reduced Exercise Price.
			
		  	A =	  	the number of Shares outstanding or deemed outstanding immediately prior to such issuance.
			
		  	B =	  	the Exercise Price in effect immediately prior to such issuance.
			
		  	C =	  	the aggregate fair value of the consideration, if any, received or receivable by the Company upon each and every issuance or deemed issuance of additional Shares (including without limitation consideration receivable upon the
issuance of securities underlying any other securities).
			
		  	Y =	  	the aggregate number of Shares outstanding or deemed outstanding immediately after such issuance.

 Upon termination of rights to purchase or acquire Shares, by lapse or otherwise, the Shares theretofore issuable, but
not issued, shall cease to be included in the formula set forth above, and the Exercise Price shall be readjusted to reflect such termination, Notwithstanding the foregoing, there shall be no adjustment to the Exercise Nice or the number of Shares
obtainable upon exercise of this Warrant with respect to a Permitted Issuance. A “Permitted Issuance” means (i) the granting of options to purchase Shares, or other stock-based benefits, to employees, directors or consultants of the
Company or the exercise thereof, pursuant to any reservation under any employee benefit plan to the extent and as in effect on the date of this Warrant, or approved thereafter by the Board of Direct of the Company, in an aggregate amount not to
exceed five percent (5%) of the Shares deemed outstanding as of the date hereof, or (ii) the issuance of Shares pursuant to the exercise of options, convertible equity securities, or other rights to acquire Shares that are outstanding on
the date of this Warrant. 
 For purposes of this Warrant, additional Shares shall be “deemed to have been issued”, “deemed issued”, or
“deemed outstanding”, if the Company shall at any time issue any of its Shares or other securities, or other rights, warrants, or options to subscribe for or purchase Shares or other securities, which, in any such case, ranks at an equal
priority with the Shares, or which includes an option to acquire or a right to convert to Shares or other securities ranking at an equal priority with the Shares at a price per share after such acquisition or conversion less than the Exercise Price.

 Upon any Triggering Event, adequate provision shall be made whereby the Holder or other holder of this Warrant shall have the right to receive and
acquire (upon exercise of this Warrant) such Shares, securities, cash, or other property as would have been issuable or payable (as part of 

  
 Page 5 of 9 

 
the Triggering Event) with respect to or in exchange for such number of outstanding Shares as would have been received had this Warrant been exercised immediately prior to such Triggering Event
(as set forth more specifically above), and the number of shares reserved by the Company for purposes of this Warrant shall he adjusted by the same proportion. In the event of a proportional adjustment under subparagraphs (a), (b) or
(c) of this Section 3.4, no adjustment shall be made in the aggregate purchase price of the Shares then covered by this Warrant, and the per-Share Exercise Price shall be adjusted accordingly, All null adjustments shall be made by the
Company, whose determination upon the same shall be subject to review and approval by the Holder. No fractional Shares shall be issued; and any fractional Share resulting from the computations pursuant to this Section 3.4 shall be rounded up to
the next whole share. The Company shall provide thirty (30) days’ prior written notice to the Holder of a Triggering Event (to the extent legally permissible, but in no case later than five (5) days after the occurrence of a
Triggering Event), its effective date, and the proposed adjustment for such Triggering Event. 
 Section 4. Shareholder Rights.
Until the valid exercise of this Warrant, the Holder shall not be entitled to any rights of a stockholder with regard to the Shares, but immediately upon the exercise of this Warrant and upon payment of the Exercise Price as provided herein, the
Holder shall be deemed to be a record holder of the Company’s Shares. Notwithstanding the foregoing, and provided (he Holder agrees in a manner reasonably satisfactory to the Company to maintain in confidence confidential and proprietary
information of the Company, the Company shall provide financial and operating information regarding the Company to the Holder annually. In addition, the Holder may request financial and operating information regarding the Company with thirty
(30) days after its receipt of the each of the notices the Company is required to provide pursuant to Sections 3.3 and 14 above, 

Section 5. Transfer of Warrant. 
 5.1
Transfer. Subject to compliance with applicable state and federal securities laws, and the terms of this Warrant, this Warrant shall be transferable, in whole or in part, by the Holder or other holder of record upon surrender of this Warrant
properly endorsed. 
 5.2 Transferee Obligations. Any transferee shall represent and warrant to the Company that it will hold this Warrant (or any
portion thereof) subject to the provisions and upon the conditions specified herein. 
 5.3 New Warrants. On any transfer referenced in this
Section 5, the Company shall issue (as applicable) a new Warrant or Warrants to the transferee (who shall then become a holder of record for all purposes under the terms of this Warrant) and to the Holder (in the event the Warrant is only
partially transferred) containing the same terms and conditions specified herein, The surrendered Warrant shall thereafter he canceled. Each such transferee shall succeed to all of the rights and assume all obligations of the Holder under this
Warrant. 
 Section 6. Lost, Stolen, Mutilated or Destroyed Warrant. If this Warrant is lost, stolen, mutilated, or destroyed, the
Company shall, on delivery of art indemnity agreement reasonably satisfactory to the Company (and, in the case of a mutilated Warrant, the surrender thereof), issue a new Warrant of like denomination and tenor as the Warrant so lost, stolen,
mutilated or destroyed. 

  
 Page 6 of 9 

 Section 7. Notice, etc.. All notices and other communications required or permitted
hereunder shall be in writing and shall be (i) personally delivered, (ii) sent by facsimile (with a copy sent the same day by certified mail, postage prepaid), or (iii) sent Federal Express or other express service addressed:
(a) if to the Holder, to the Holder’s address appearing in the records of the Company or such other address as the Holder shall have furnished to the Company in writing, (b) if to any other holder of the Warrant, to such address as
such holder shall have furnished the Company in writing, or, until any such holder so furnishes an address to the Company, then to and at the address of the last holder of the Warrant who has so furnished an address to the Company, or (e) if to
the Company, to the Company’s address appearing in the records of the Holder, or at such other address as the Company shall have furnished to the Holder and each such other holder in writing. Notice shall be deemed effective on the date
dispatched if by personal delivery, on the date transmitted by facsimile (if confirmed by mail pursuant to this Section 7) or two (2) days after mailing if by Federal Express or express service. 

Section 8. General Provisions. The headings in this Warrant are for purposes of reference only and shall not limit or otherwise
affect the meaning hereof, The provisions of this Warrant are deemed by the parties to be severable, and the unenforceability of any one or more provisions shall not invalidate or make unenforceable the other provisions. The rights, duties, and
obligations of the parties shall inure to the benefit of and be binding on their respective successors and assigns. Neither this Warrant nor any term hereof may be changed, waived, discharged, or terminated orally, but only by an instrument in
writing signed by the party against which enforcement of change, waiver, discharge, or termination is sought. 
 Section 9. Choice of
Law. This Warrant shall be construed and governed by the laws of the State of North Carolina, excepting only its conflict of law principles. 

Section 10. Acceptance. Receipt of this Warrant by the Holder shall constitute acceptance of and agreement to the foregoing terms
and conditions by the parties hereto. 
 Section 11. Entire Agreement. This Warrant reflects the complete understanding of the
parties and constitutes their entire agreement regarding the subject matter hereof, all prior negotiations, representations, agreements and understanding having been merged herein. 

  
 Page 7 of 9 

 IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its duly authorized
officers. 
  

			
	G-ZERO THERAPEUTICS, INC.
		
	By:	 	  

 
			
		
	Printed Name:	 	  

 
			
		
	Title:	 	  

  
 Page 8 of 9 

 Exhibit A 

NOTICE OF EXERCISE OF WARRANT 

(To be signed only upon exercise of Warrant) 

The undersigned, the holder of the within Warrant, hereby (i) irrevocably elects to exercise the right of purchase represented by such Warrant for, and
to purchase thereunder,                 Shares (as that term is defined in the within Warrant) pursuant to the terms of the Warrant, and (ii) hereby elects to make
payment in full for the number of Shares so purchased by (a) payment of $            cash or cashier’s check or, hereby serves notice that
$            has been credited as payment in principal of the Company’s loan from the Holder in full payment of the aggregate purchase price for such Shares, or (b) in lieu of the
payment of cash, the exchange of the Warrant for a lesser number of Shares, as provided in the within Warrant. 
 The undersigned requests that the
certificates for such Shares be issued in the name of, and be delivered to,
                                        whose
address is
                                        . 

 

			
	Dated:	 	  

 

			
	[HOLDER]
		
	By:	 	  

 
			
		
	Printed Name:	 	  

 
			
		
	Tide:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00269-of-00352.parquet"}]]