Document:

Exhibit 10.3 

Heska
Corporation 1997 Stock Incentive Plan

Stock
Option Agreement

(Outside
Directors)

 

	Tax Treatment	This option is intended to be a nonstatutory option.
	
        Vesting/

        Exercisability
	
        This option is immediately exercisable,
        but subject to vesting as indicated in the Notice of Stock Option Grant. In the event of termination of your service as an Outside
        Director of the Company, any unvested shares issued upon exercise are subject to repurchase by the Company at the same price as
        the original Exercise Price Per Share. The Company's right to repurchase such shares shall lapse as the shares become vested as
        indicated in the Notice of Stock Option Grant.

        In addition, this option becomes vested
        in full if one of the following events occurs:

        ·     
          Your service as an Outside Director of the Company terminates because of death, total and permanent disability, or
        retirement         at or after age 65, or

        ·        
        A Change in Control with respect to the Company occurs while you are an Outside Director of the Company.

        No additional shares become vested after
        your service as an Employee, Consultant or Outside Director of the Company or a Subsidiary has terminated for any reason other
        than those outlined herein.

	Term	This option expires in any event at the close of business at Company headquarters on the day before the 10th anniversary of the Date of Grant, as shown in the Notice of Stock Option Grant.  (It will expire earlier if your service terminates, as described below.)
	Regular

                                                                                Termination
	If your service as an Employee, Consultant or Outside Director of the Company or a Subsidiary terminates for any reason except death or total and permanent disability, then this option will expire at the close of business at Company headquarters on the date three months after your termination date.  The Company determines when your service terminates for this purpose.
	Death	If your service as an Employee, Consultant or Outside Director of the Company or a Subsidiary terminates because of your death, then this option will expire at the close of business at Company headquarters on the date 12 months after the date of death.
	Disability	If your service as an Employee, Consultant
        or Outside Director of the Company or a Subsidiary terminates because of your total and permanent disability, then this option
        will expire at the close of business at Company headquarters on the date 12 months after your termination date.
	 	 

    	 

    	 

    

 

		
        For all purposes under this Agreement,
“total and permanent disability” means that you are unable to engage in any substantial gainful activity by reason
of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted, or can
be expected to last, for a continuous period of not less than one year.

	Restrictions on

                                                                                Exercise
	The Company will not permit you to exercise this option if the issuance of shares at that time would violate any law or regulation.
	Notice of Exercise	
        When you wish to exercise this option,
        you must notify the Company by filing the proper “Notice of Exercise” form at the address given on the form. Your notice
        must specify how many shares you wish to purchase. The exercise will be effective when the Company receives the Notice of Exercise
        with the option exercise payment described herein.

        If someone else wants to exercise this
        option after your death, that person must prove to the Company's satisfaction that he or she is entitled to do so.

	Exercise of

                                                                                Unvested
                                         Shares
	Exercise of unvested shares is allowed under the Plan.  If you would like to exercise your option before it is vested, you must complete a Stock Repurchase Agreement, which provides for the repurchase of that portion of the shares that remain unvested at the time of your termination.  
	Form of Payment	
        When you submit your notice of exercise,
        you must include payment of the option exercise price for the shares you are purchasing. Payment may be made in one (or a combination
        of two or more) of the following forms:

        

        ·      
        Your personal check, a cashier's check or a money order.

        ·     
        Certificates for shares of Company stock that you own, along with any forms needed to affect a transfer of those shares
        to the Company. The value of the shares, determined as of the effective date of the option exercise, will be applied to the option
        exercise price. However, you may not surrender shares of Company stock in payment of the exercise price if your action would cause
        the Company to recognize compensation expense (or additional compensation expense) with respect to this option for financial reporting
        purposes.

        ·      
        Irrevocable directions to a securities broker approved by the Company to sell all or part of your option shares and to deliver
        to the Company proceeds from the sale in an amount sufficient to pay the option exercise price and any withholding taxes. (The
        balance of the sale proceeds, if any, will be delivered to you.) The directions must be given by signing a special “Notice
        of Exercise” form provided by the Company.

    	 

    	 

    

 

 

	Withholding Taxes

                                                                                and
                                         Stock

                                                                                Withholding
	You will not be allowed to exercise this option unless you make arrangements acceptable to the Company to pay any withholding taxes that may be due as a result of the option exercise.  These arrangements may include (with the Company’s approval) withholding shares of Company stock that otherwise would be issued to you when you exercise this option.  The value of these shares, determined as of the effective date of the option exercise, will be applied to the withholding taxes.
	Repurchase Rights	In the event that you exercise unvested shares through the execution of a Stock Repurchase Agreement, the Company will have 90 days to repurchase any shares that remain unvested at the time of your termination.  The terms of any such repurchase will be set forth in the Stock Repurchase Agreement.
	Restrictions on

                                                                                Resale
	By signing this Agreement, you agree not to sell any option shares at a time when applicable laws, Company policies or an agreement between the Company and its underwriters prohibit a sale.  This restriction will apply as long as you are an Employee, Consultant or Outside Director of the Company or a Subsidiary.
	Transfer of Option	
        Prior to your death, only you may exercise
        this option. You cannot transfer or assign this option. For instance, you may not sell this option or use it as security for a
        loan. You may, however, dispose of this option in your will, by the laws of descent and distribution or through a beneficiary designation.

        Regardless of any marital property settlement
        agreement, the Company is not obligated to honor a notice of exercise from your former spouse, nor is the Company obligated to
        recognize your former spouse's interest in your option in any other way.

	Retention Rights	Neither your option nor this Agreement give you the right to be employed or otherwise retained by the Company or a Subsidiary in any capacity.
	Stockholder Rights	You, or your estate or heirs, have no rights as a stockholder of the Company until you have exercised this option by giving the required notice to the Company and paying the exercise price.  

    	 

    	 

    

 

	Applicable Law	This Agreement will be interpreted and enforced under the laws of the State of Colorado (without giving effect to its conflict of laws provisions).
	The Plan and Other Agreements	
        The 1997 Stock Incentive Plan is incorporated
        in this Agreement by reference. Unless otherwise defined herein, all capitalized terms herein have the same defined meanings as
        in the 1997 Stock Incentive Plan.

        This Agreement and the Plan constitute
        the entire understanding between you and the Company regarding this option. Any prior agreements, commitments or negotiations concerning
        this option are superseded. This Agreement may be amended only by another written agreement, signed by both parties.

By
signing the Notice of Stock option Grant of this Agreement, you agree to all of the terms and conditions described above and in
the 1997 Stock Incentive Plan.EX-4.1

 Exhibit 4.1 

VWR FUNDING, INC. 
 as Issuer 

and 
 THE GUARANTORS PARTY HERETO

  
  

4.625% SENIOR NOTES DUE 2022 
  

 
 INDENTURE 

DATED AS OF MARCH 25, 2015 
  

 
 LAW DEBENTURE
TRUST COMPANY OF NEW YORK 
 as Trustee 

DEUTSCHE BANK AG, LONDON BRANCH 

as Paying Agent 
 DEUTSCHE BANK
LUXEMBOURG S.A. 
 as Registrar and Transfer Agent 

 TABLE OF CONTENTS 
  

					
	 	  	 	  	 Page

	
	ARTICLE I
	
	DEFINITIONS AND INCORPORATION BY REFERENCE
			
	 SECTION 1.1
	  	Definitions.	  	1
	 SECTION 1.2
	  	Other Definitions.	  	34
	 SECTION 1.3
	  	[Reserved].	  	35
	 SECTION 1.4
	  	Rules of Construction.	  	35
	
	ARTICLE II
	
	THE NOTES
			
	 SECTION 2.1
	  	Form and Dating.	  	35
	 SECTION 2.2
	  	Execution and Authentication.	  	37
	 SECTION 2.3
	  	Registrar; Transfer Agent and Paying Agent.	  	38
	 SECTION 2.4
	  	Paying Agent to Hold Money in Trust.	  	38
	 SECTION 2.5
	  	Holder Lists.	  	39
	 SECTION 2.6
	  	Book-Entry Provisions for Global Securities.	  	39
	 SECTION 2.7
	  	Replacement Notes.	  	41
	 SECTION 2.8
	  	Outstanding Notes.	  	41
	 SECTION 2.9
	  	Treasury Notes.	  	42
	 SECTION 2.10
	  	Temporary Notes.	  	42
	 SECTION 2.11
	  	Cancellation.	  	42
	 SECTION 2.12
	  	Defaulted Interest.	  	42
	 SECTION 2.13
	  	[Reserved].	  	43
	 SECTION 2.14
	  	Computation of Interest.	  	43
	 SECTION 2.15
	  	ISIN and Common Code Numbers.	  	43
	 SECTION 2.16
	  	Special Transfer Provisions.	  	43
	 SECTION 2.17
	  	Issuance of Additional Notes.	  	44
	
	ARTICLE III
	
	REDEMPTION AND PREPAYMENT
			
	 SECTION 3.1
	  	Notices to Trustee.	  	45
	 SECTION 3.2
	  	Selection of Notes to Be Redeemed.	  	45
	 SECTION 3.3
	  	Notice of Redemption.	  	46
	 SECTION 3.4
	  	Effect of Notice of Redemption.	  	47
	 SECTION 3.5
	  	Deposit of Redemption of Purchase Price.	  	47
	 SECTION 3.6
	  	Notes Redeemed in Part.	  	48
	 SECTION 3.7
	  	Optional Redemption.	  	48
	 SECTION 3.8
	  	Mandatory Redemption.	  	49
	 SECTION 3.9
	  	Offer to Purchase.	  	49

  
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	 	  	 	  	 Page

	
	ARTICLE IV
	
	COVENANTS
			
	 SECTION 4.1
	  	Payment of Notes.	  	50
	 SECTION 4.2
	  	Maintenance of Office or Agency.	  	51
	 SECTION 4.3
	  	Reports.	  	51
	 SECTION 4.4
	  	Compliance Certificate.	  	52
	 SECTION 4.5
	  	Taxes.	  	53
	 SECTION 4.6
	  	Stay, Extension and Usury Laws.	  	53
	 SECTION 4.7
	  	Limitation on Restricted Payments.	  	53
	 SECTION 4.8
	  	Limitation on Dividends and Other Payment Restrictions Affecting Subsidiaries.	  	60
	 SECTION 4.9
	  	Limitation on Incurrence of Indebtedness and Issuance of Preferred Stock.	  	62
	 SECTION 4.10
	  	Limitation on Asset Sales.	  	67
	 SECTION 4.11
	  	Limitation on Transactions with Affiliates.	  	69
	 SECTION 4.12
	  	Limitation on Liens.	  	70
	 SECTION 4.13
	  	Payments for Consent.	  	71
	 SECTION 4.14
	  	Offer to Purchase upon Change of Control.	  	71
	 SECTION 4.15
	  	Corporate Existence.	  	73
	 SECTION 4.16
	  	Business Activities.	  	73
	 SECTION 4.17
	  	Additional Guarantees.	  	73
	 SECTION 4.18
	  	Maintenance of Listing.	  	74
	 SECTION 4.19
	  	Further Instruments and Acts.	  	74
	 SECTION 4.20
	  	Fall Away Event.	  	74
	
	ARTICLE V
	
	SUCCESSORS
			
	 SECTION 5.1
	  	Merger, Consolidation or Sale of Assets.	  	74
	 SECTION 5.2
	  	Successor Corporation Substituted.	  	75
	
	ARTICLE VI
	
	DEFAULTS AND REMEDIES
			
	 SECTION 6.1
	  	Events of Default.	  	76
	 SECTION 6.2
	  	Acceleration.	  	77
	 SECTION 6.3
	  	Other Remedies.	  	79
	 SECTION 6.4
	  	Waiver of Past Defaults.	  	79
	 SECTION 6.5
	  	Control by Majority.	  	79
	 SECTION 6.6
	  	Limitation on Suits.	  	79
	 SECTION 6.7
	  	Rights of Holders of Notes to Receive Payment.	  	80
	 SECTION 6.8
	  	Collection Suit by Trustee.	  	80
	 SECTION 6.9
	  	Trustee May File Proofs of Claim.	  	80
	 SECTION 6.10
	  	Priorities.	  	81
	 SECTION 6.11
	  	Undertaking for Costs.	  	81

							
	 	  	 	  	Page	 
	
	ARTICLE VII	  
	
	TRUSTEE	  
			
	 SECTION 7.1
	  	Duties of Trustee.	  	 	81	  
	 SECTION 7.2
	  	Rights of Trustee.	  	 	82	  
	 SECTION 7.3
	  	Individual Rights of Trustee.	  	 	83	  
	 SECTION 7.4
	  	Trustee’s Disclaimer.	  	 	84	  
	 SECTION 7.5
	  	Notice of Defaults.	  	 	84	  
	 SECTION 7.6
	  	[Reserved].	  	 	84	  
	 SECTION 7.7
	  	Compensation and Indemnity.	  	 	84	  
	 SECTION 7.8
	  	Replacement of Trustee.	  	 	85	  
	 SECTION 7.9
	  	Successor Trustee by Merger, Etc.	  	 	86	  
	 SECTION 7.10
	  	Eligibility; Disqualification.	  	 	86	  
	 SECTION 7.11
	  	[Reserved].	  	 	86	  
	 SECTION 7.12
	  	Trustee’s Application for Instructions from the Company.	  	 	86	  
	
	ARTICLE VIII	  
	
	DEFEASANCE; DISCHARGE OF THE INDENTURE	  
			
	 SECTION 8.1
	  	Option to Effect Legal Defeasance or Covenant Defeasance.	  	 	86	  
	 SECTION 8.2
	  	Legal Defeasance.	  	 	86	  
	 SECTION 8.3
	  	Covenant Defeasance.	  	 	87	  
	 SECTION 8.4
	  	Conditions to Legal or Covenant Defeasance.	  	 	88	  
	 SECTION 8.5
	  	Deposited Money and Government Securities to Be Held in Trust; Other Miscellaneous Provisions.	  	 	89	  
	 SECTION 8.6
	  	Repayment to Company.	  	 	89	  
	 SECTION 8.7
	  	Reinstatement.	  	 	89	  
	 SECTION 8.8
	  	Discharge.	  	 	90	  
	
	ARTICLE IX	  
	
	AMENDMENT, SUPPLEMENT AND WAIVER	  
			
	 SECTION 9.1
	  	Without Consent of Holders of the Notes.	  	 	91	  
	 SECTION 9.2
	  	With Consent of Holders of Notes.	  	 	92	  
	 SECTION 9.3
	  	[Reserved].	  	 	93	  
	 SECTION 9.4
	  	Revocation and Effect of Consents.	  	 	93	  
	 SECTION 9.5
	  	Notation on or Exchange of Notes.	  	 	93	  
	 SECTION 9.6
	  	Trustee to Sign Amendments, Etc.	  	 	93	  
	
	ARTICLE X	  
	
	[RESERVED]	  

							
	 	  	 	  	Page	 
	
	ARTICLE XI	  
	
	NOTE GUARANTEES	  
			
	 SECTION 11.1
	  	Guarantees.	  	 	94	  
	 SECTION 11.2
	  	 Execution and Delivery of Guarantee.
	  	 	95	  
	 SECTION 11.3
	  	Severability.	  	 	95	  
	 SECTION 11.4
	  	Limitation of Guarantors’ Liability.	  	 	95	  
	 SECTION 11.5
	  	Guarantors May Consolidate, Etc., on Certain Terms.	  	 	96	  
	 SECTION 11.6
	  	Releases Following Sale of Assets.	  	 	97	  
	 SECTION 11.7
	  	Release of a Guarantor.	  	 	97	  
	 SECTION 11.8
	  	Benefits Acknowledged.	  	 	98	  
	
	ARTICLE XII	  
	
	MISCELLANEOUS	  
			
	 SECTION 12.1
	  	[Reserved].	  	 	98	  
	 SECTION 12.2
	  	Notices.	  	 	98	  
	 SECTION 12.3
	  	[Reserved].	  	 	99	  
	 SECTION 12.4
	  	Certificate and Opinion as to Conditions Precedent.	  	 	99	  
	 SECTION 12.5
	  	Statements Required in Certificate or Opinion.	  	 	100	  
	 SECTION 12.6
	  	Rules by Trustee and Agents.	  	 	100	  
	 SECTION 12.7
	  	No Personal Liability of Directors, Officers, Employees and Stockholders.	  	 	100	  
	 SECTION 12.8
	  	Governing Law.	  	 	100	  
	 SECTION 12.9
	  	No Adverse Interpretation of Other Agreements.	  	 	100	  
	 SECTION 12.10
	  	Successors.	  	 	101	  
	 SECTION 12.11
	  	Severability.	  	 	101	  
	 SECTION 12.12
	  	Counterpart Originals.	  	 	101	  
	 SECTION 12.13
	  	Table of Contents, Headings, Etc.	  	 	101	  
	 SECTION 12.14
	  	Acts of Holders.	  	 	101	  
	 SECTION 12.15
	  	Waiver of Jury Trial.	  	 	102	  
	 SECTION 12.16
	  	Force Majeure.	  	 	102	  
	 SECTION 12.17
	  	USA Patriot Act.	  	 	102	  
	 SECTION 12.18
	  	Judgment Currency.	  	 	102	  

 EXHIBITS 
  

			
	Exhibit A		FORM OF NOTE
	Exhibit B		FORM OF NOTATIONAL GUARANTEE
	Exhibit C		 FORM OF CERTIFICATE TO BE DELIVERED IN CONNECTION WITH TRANSFERS PURSUANT TO RULE 144A

	Exhibit D		 FORM OF CERTIFICATE TO BE DELIVERED IN CONNECTION WITH TRANSFERS PURSUANT TO REGULATION S

  
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 This Indenture, dated as of March 25, 2015 is by and among VWR Funding, Inc., a Delaware
corporation (the “Company”), each Guarantor (as defined herein), Law Debenture Trust Company of New York, as trustee (the “Trustee”), Deutsche Bank AG, London Branch, as Paying Agent, and Deutsche Bank Luxembourg
S.A., as Registrar and Transfer Agent. 
 Each party agrees as follows for the benefit of each other and for the equal and ratable benefit
of the holders of (i) the Company’s 4.625% Senior Notes due 2022 issued on the date hereof (the “Initial Notes”) and (ii) Additional Notes (as defined herein and, together with the Initial Notes, the
“Notes”). 
 ARTICLE I 

DEFINITIONS AND INCORPORATION BY REFERENCE 

SECTION 1.1 Definitions. 

“Acquired Debt” means, with respect to any specified Person: 

(a) Indebtedness of any other Person existing at the time such other Person is merged with or into or became a Restricted
Subsidiary of such specified Person, including Indebtedness incurred in connection with, or in contemplation of, or to provide all or any portion of the funds or credit support utilized in connection with, such other Person merging with or into, or
becoming a Restricted Subsidiary of, such specified Person; and 
 (b) Indebtedness secured by an existing Lien encumbering
any asset acquired by such specified Person. 
 “Additional Notes” means Notes (other than the Initial Notes) issued
pursuant to Article II hereof and otherwise in compliance with the provisions of this Indenture. 
 “Affiliate”
of any specified Person means any other Person directly or indirectly controlling or controlled by or under direct or indirect common control with such specified Person. For purposes of this definition, “control” (including, with
correlative meanings, the terms “controlling,” “controlled by” and “under common control with”), as used with respect to any Person, shall mean the possession, directly or indirectly, of the power to direct or cause the
direction of the management or policies of such Person, whether through the ownership of voting securities, by agreement or otherwise. 

“Agent” means any Registrar, Paying Agent, Transfer Agent or co-registrar. 

“Applicable Premium” means, with respect to any Note on any applicable redemption date, the excess of: 

(a) the present value at such redemption date of (i) the redemption price at April 15, 2018 (such redemption price
being set forth in Section 3.7) plus (ii) all required interest payments due on the Notes through April 15, 2018 (excluding accrued but unpaid interest to the date of redemption), computed using a discount rate equal to
the Bund Rate as of such redemption date plus 50 basis points; over 
 (b) the then outstanding principal amount of
the Notes. 
 “Asset Sale” means (i) the sale, conveyance, transfer, lease (as lessor) or other voluntary disposition
(whether in a single transaction or a series of related transactions) of property or assets (including by 

 
way of a Sale and Lease-Back Transaction) of the Company (other than the sale of Equity Interests of the Company) or any of its Restricted Subsidiaries (each referred to in this definition as a
“disposition”) or (ii) the issuance or sale of Equity Interests of any Restricted Subsidiary (whether in a single transaction or a series of related transactions), in each case, other than: 

(a) a disposition of Cash Equivalents or Investment Grade Securities or obsolete, damaged or worn out property or equipment in
the ordinary course of business or inventory (or other assets) held for sale in the ordinary course of business and dispositions of property no longer used or useful in the conduct of the business of the Company and its Restricted Subsidiaries or
the disposition of inventory in the ordinary course of business; 
 (b) the disposition of all or substantially all of the
assets of the Company in a manner permitted pursuant to Section 5.1 or any disposition that constitutes a Change of Control; 

(c) the making of any Restricted Payment or Permitted Investment that is permitted to be made, and is made, pursuant to
Section 4.7 or the granting of a Lien permitted by Section 4.12; 
 (d) any disposition of assets or
issuance or sale of Equity Interests of any Restricted Subsidiary (other than directors’ qualifying shares or shares required by applicable law to be held by a Person other than the Company or a Restricted Subsidiary) in any transaction or
series of transactions with an aggregate fair market value of less than $35.0 million; 
 (e) any disposition of property or
assets or issuance of securities by a Restricted Subsidiary to the Company or by the Company or a Restricted Subsidiary to another Restricted Subsidiary; 

(f) the lease, assignment, sublease, license or sublicense of any real or personal property in the ordinary course of business;

 (g) any issuance or sale of Equity Interests in, or Indebtedness or other securities of, an Unrestricted Subsidiary; 

(h) foreclosures on assets or transfers by reason of eminent domain; 

(i) disposition of an account receivable in connection with the collection or compromise thereof; 

(j) sales of accounts receivable, or participations therein, in connection with any Receivables Facility; 

(k) the issuance by a Restricted Subsidiary of Disqualified Stock or Preferred Stock that is permitted by
Section 4.9; 
 (l) any financing transaction with respect to property built or acquired by the Company or any
Restricted Subsidiary after the Issue Date, including Sale and Lease-Back Transactions and Receivables Facility financings permitted under this Indenture; 

(m) transfers of property subject to casualty or condemnation proceedings (including in lieu thereof) upon the receipt of the
net cash proceeds therefor; 

  
 -2- 

 (n) the abandonment of intellectual property rights in the ordinary course of
business, which in the reasonable good faith determination of the Company or a Restricted Subsidiary are not material to the conduct of the business of the Company and its Restricted Subsidiaries taken as a whole; 

(o) voluntary terminations of Hedging Obligations; 

(p) Dispositions permitted under this Indenture (including Sale and Lease-Back Transactions) by a Foreign Subsidiary designed
to generate foreign distributable reserves; 
 (q) any Permitted Asset Swap; and 

(r) Sale and Lease-Back Transactions involving (i) real property owned on the Issue Date, (ii) property acquired not
more than 180 days prior to such Sale and Lease-Back Transaction for cash in an amount at least equal to the cost of such property and (iii) other property for cash consideration if the sale is treated as an Asset Sale. 

“Asset Sale Offer” means an Offer to Purchase required to be made by the Company or a Restricted Subsidiary pursuant to
Section 4.10 to all Holders. 
 “Bankruptcy Law” means Title 11, U.S. Code or any similar Federal, state or
foreign law for the relief of debtors. 
 “Beneficial Owner” has the meaning assigned to such term in Rule 13d-3 and Rule 13d-5 under the Exchange Act, except that in calculating the beneficial ownership of any particular “person” (as that term is used in
Section 13(d)(3) of the Exchange Act), such “person” will be deemed to have beneficial ownership of all securities that such “person” has the right to acquire by conversion or exercise of other securities, whether such
right is currently exercisable or is exercisable only upon the occurrence of a subsequent condition. The terms “Beneficially Owns,” “Beneficially Owned” and “Beneficial Ownership” have a corresponding meaning. 

“Board of Directors” means: 

(a) with respect to a corporation, the board of directors of the corporation; 

(b) with respect to a partnership, the board of directors of the general partner of the partnership; and 

(c) with respect to any other Person, the board or committee of such Person serving a similar function. 

“Board Resolution” means a copy of a resolution certified by the Secretary or an Assistant Secretary of the Company or any
Restricted Subsidiary to have been duly adopted by the Board of Directors, unless the context specifically requires that such resolution be adopted by a majority of the Disinterested Directors, in which case by a majority of such directors, and to
be in full force and effect on the date of such certification and delivered to the Trustee. 

  
 -3- 

 “Bund Rate” means, as of any redemption date, the rate per annum equal to the
equivalent yield to maturity as of such redemption date of the Comparable German Bund Issue, assuming a price for the Comparable German Bund Issue (expressed as a percentage of its principal amount) equal to the Comparable German Bund Price for such
relevant date, where: 
 (1) “Comparable German Bund Issue” means the German Bundesanleihe security selected
by any Reference German Bund Dealer as having a fixed maturity most nearly equal to the period from such redemption date to April 15, 2018, and that would be utilized, at the time of selection and in accordance with customary financial
practice, in pricing new issues of euro-denominated corporate debt securities in a principal amount approximately equal to the then outstanding principal amount of the Notes and of a maturity most nearly equal to April 15, 2018; provided,
however, that, if the period from such redemption date to April 15, 2018 is less than one year, a fixed maturity of one year shall be used; 

(2) “Comparable German Bund Price” means, with respect to any relevant date, the average of all Reference
German Bund Dealer Quotations for such date (which, in any event, must include at least two such quotations), after excluding the highest and lowest such Reference German Bund Dealer Quotations, or if the Company obtains fewer than four such
Reference German Bund Dealer Quotations, the average of all such quotations; 
 (3) “Reference German Bund
Dealer” means any dealer of German Bundesanleihe securities appointed by the Company in good faith; and 
 (4)
“Reference German Bund Dealer Quotations” means, with respect to each Reference German Bund Dealer and any relevant date, the average as determined by the Company of the bid and offered prices for the Comparable German Bund Issue
(expressed in each case as a percentage of its principal amount) quoted in writing to the Company by such Reference German Bund Dealer at 3:30 p.m., Frankfurt, Germany time, on the third Business Day preceding the relevant date. 

“Business Day” means each day which is not a Saturday, a Sunday or a day on which commercial banking institutions are not
required to be open in the State of New York, Ireland, London, England or at the place of payment. 
 “Calculation Date”
has the meaning set forth in the definition of “Fixed Charge Coverage Ratio.” 
 “Capital Stock” means: 

(1) in the case of a corporation, capital stock; 

(2) in the case of an association or business entity, any and all shares, interests, participations, rights or other
equivalents (however designated) of capital stock; 
 (3) in the case of a partnership or limited liability company,
partnership or membership interests (whether general or limited); and 
 (4) any other interest or participation that confers
on a Person the right to receive a share of the profits and losses of, or distributions of assets of, the issuing Person. 

“Capitalized Lease Obligation” means, at the time any determination thereof is to be made, the amount of the liability in
respect of a capital lease that would at such time be required to be capitalized and reflected as a liability on a balance sheet (excluding the footnotes thereto) in accordance with GAAP (except for temporary treatment of construction-related
expenditures under EITF 97-10, “The Effect of Lessee Involvement in Asset Construction,” which will ultimately be treated as operating leases upon a Sale and Lease-Back Transaction). 

  
 -4- 

 “Cash Contribution Amount” means the aggregate amount of cash contributions made
to the capital of the Company or any other Guarantor described in the definition of “Contribution Indebtedness.” 
 “Cash
Equivalents” means: 
 (a) U.S. dollars; 

(b) (i) Sterling, Singapore Dollars, Swedish Kroner, Canadian Dollars, euro, or any national currency of any participating
member state of the economic and monetary union contemplated by the Treaty on European Union; or 
 (ii) in the case of the
Company or a Restricted Subsidiary, such local currencies held by them from time to time in the ordinary course of business; 

(c) securities issued or directly and fully and unconditionally guaranteed or insured by the U.S. government or any agency or
instrumentality thereof the securities of which are unconditionally guaranteed as a full faith and credit obligation of such government with maturities of 24 months or less from the date of acquisition; 

(d) certificates of deposit, time deposits and eurodollar time deposits with maturities of one year or less from the date of
acquisition, bankers’ acceptances with maturities not exceeding one year and overnight bank deposits, in each case with (i) any lender under the Credit Agreement or an Affiliate thereof or (ii) any commercial bank having capital and
surplus of not less than $250.0 million in the case of U.S. banks and $100.0 million (or the U.S. dollar equivalent as of the date of determination) in the case of non-U.S. banks; 

(e) repurchase obligations for underlying securities of the types described in clauses (c) and (d) above entered into
with any financial institution meeting the qualifications specified in clause (d) above; 
 (f) commercial paper rated
at least P-2 by Moody’s or at least A-2 by S&P and in each case maturing within 24 months after the date of creation thereof; 

(g) marketable short-term money market and similar securities having a rating of at least
P-2 or A-2 from either Moody’s or S&P, respectively (or, if at any time neither Moody’s nor S&P shall be rating such obligations, an equivalent rating
from another Rating Agency) and in each case maturing within 24 months after the date of creation thereof; 
 (h) investment
funds investing 95% of their assets in securities of the types described in clauses (a) through (g) above; 
 (i)
readily marketable direct obligations issued by any state, commonwealth or territory of the United States or any political subdivision or taxing authority thereof having an Investment Grade Rating from either Moody’s or S&P with maturities
of 24 months or less from the date of acquisition; 
 (j) Indebtedness or Preferred Stock issued by Persons with a rating of
“A” or higher from S&P or “A2” or higher from Moody’s with maturities of 24 months or less from the date of acquisition; 

  
 -5- 

 (k) Investments with average maturities of 12 months or less from the date of
acquisition in money market funds rated A- (or the equivalent thereof) or better by S&P or A3 (or the equivalent thereof) or better by Moody’s; 

(l) shares of investment companies that are registered under the Investment Company Act of 1940 and substantially all the
investments of which are one or more of the types of securities described in clauses (a) through (k) above; and 

(m) in the case of any Foreign Subsidiary, investments of comparable tenure and credit quality to those described in the
foregoing clauses (a) through (l) above or other high quality short term investments, in each case, customarily utilized in countries in which such Foreign Subsidiary operates for short term cash management purposes. 

Notwithstanding the foregoing, Cash Equivalents shall include amounts denominated in currencies other than those set forth in clauses
(a) and (b) above; provided that such amounts are converted into any currency listed in clauses (a) and (b) as promptly as practicable and in any event within ten Business Days following the receipt of such amounts. 

“Cash Pooling Arrangements” means a deposit account arrangement among a single depository institution, the Company and one or
more Foreign Subsidiaries involving the pooling of cash deposits in and overdrafts in respect of one or more deposit accounts (each located outside of the United States and any States and territories thereof) with such institution by the Company and
such Foreign Subsidiaries for cash management purposes. 
 “Certificated Notes” means Notes that are in the form of
Exhibit A attached hereto other than Global Notes. 
 “Change of Control” means the occurrence of any of the
following: 
 (a) the sale, lease, transfer or other conveyance, in one or a series of related transactions, of all or
substantially all of the assets of the Company and its Subsidiaries, taken as a whole, to any Person other than to a Permitted Holder; 

(b) the acquisition by any Person or group (within the meaning of Section 13(d)(3) or Section 14(d)(2) of
the Exchange Act, or any successor provision), including any group acting for the purpose of acquiring, holding or disposing of securities (within the meaning of Rule 13d-5(b)(1) under the Exchange
Act), other than the Permitted Holders, in a single transaction or in a related series of transactions, by way of merger, consolidation or other business combination or purchase of Beneficial Ownership, directly or indirectly, of 50% or more of the
total voting power of the Voting Stock of the Company or any of its direct or indirect parent entities, including, without limitation, Parent; or 

(c) the first day on which the majority of the Board of Directors of the Company then in office shall cease to consist of
Continuing Directors. 
 “Change of Control Offer” means an Offer to Purchase required to be made by the Company pursuant
to Section 4.14 to all Holders. 
 “Clearing System” means each of Euroclear and Clearstream. 

“Clearstream” means Clearstream Banking, Société Anonyme and any successor thereto. 

  
 -6- 

 “Code” means the United States Internal Revenue Code of 1986, as amended from
time to time, and the regulations promulgated and rulings issued thereunder. Section references to the Code are to the Code, as in effect on the Issue Date, and any subsequent provisions of the Code, amendatory thereof, supplemental thereto or
substituted therefor. 
 “Commission” means the U.S. Securities and Exchange Commission. 

“Common Depositary” means a depositary common to Euroclear and Clearstream and thereafter Common Depositary shall mean or
include such Person who is then a Common Depositary hereunder. 
 “Common Stock” of any Person means Capital Stock in such
Person that do not rank prior, as to the payment of dividends or as to the distribution of assets upon any voluntary or involuntary liquidation, dissolution or winding up of such Person, to Capital Stock of any other class in such Person. 

“Company” has the meaning set forth in the preamble hereto. 

“Consolidated Depreciation and Amortization Expense” means, with respect to any Person for any period, the total amount of
depreciation and amortization expense, including the amortization of deferred financing fees, and other non-cash charges (excluding any non-cash item that represents an accrual or reserve for a cash expenditure for a future period) of such Person
and its Restricted Subsidiaries for such period on a consolidated basis and otherwise determined in accordance with GAAP. 

“Consolidated Interest Expense” means, with respect to any Person for any period, without duplication, the sum of: 

(a) consolidated interest expense of such Person and its Restricted Subsidiaries for such period, to the extent such expense
was deducted (and not added back) in computing Consolidated Net Income (including (i) amortization of original issue discount resulting from the issuance of Indebtedness at less than par, (ii) all commissions, discounts and other fees and
charges owed with respect to letters of credit or bankers acceptances, (iii) non-cash interest expense (but excluding any non-cash interest expense attributable to the movement in the mark-to-market valuation of Hedging Obligations or other
derivative instruments pursuant to GAAP), (iv) the interest component of Capitalized Lease Obligations, (v) net payments, if any, pursuant to interest rate Hedging Obligations with respect to Indebtedness, (vi) net losses on Hedging
Obligations or other derivative instruments entered into for the purpose of hedging interest rate risk and (vii) costs of surety bonds in connection with financing activities, and excluding (x) amortization of deferred financing fees, debt
issuance costs, commissions, fees and expenses, (y) any expensing of bridge, commitment and other financing fees and (z) commissions, discounts, yield and other fees and charges (including any interest expense) related to any Receivables
Facility); plus 
 (b) consolidated capitalized interest of such Person and its Restricted Subsidiaries for such
period, whether paid or accrued; less 
 (c) interest income of such Person and its Restricted Subsidiaries for such
period. 
 For purposes of this definition, interest on a Capitalized Lease Obligation shall be deemed to accrue at an interest rate
reasonably determined by the Company to be the rate of interest implicit in such Capitalized Lease Obligation in accordance with GAAP. 

  
 -7- 

 “Consolidated Net Income” means, with respect to any Person for any period, the
aggregate of the Net Income of such Person and its Restricted Subsidiaries for such period, on a consolidated basis, and otherwise determined in accordance with GAAP; provided, however, that (without duplication): 

(a) any pro forma after-tax effect (using a reasonable estimate based on applicable tax rates) of extraordinary,
non-recurring or unusual gains or losses (less all fees and expenses relating thereto) or expenses, severance, integration costs, relocation costs and curtailments or modifications to pension and post-retirement employee benefit plans shall
be excluded, 
 (b) the Net Income for such period shall not include the cumulative effect of a change in accounting
principles during such period, 
 (c) any pro forma after-tax effect (using a reasonable estimate based on
applicable tax rates) of income (loss) from disposed or discontinued operations and any net after-tax gains or losses on disposal of disposed, abandoned or discontinued operations shall be excluded, 

(d) any pro forma after-tax effect (using a reasonable estimate based on applicable tax rates) of gains or losses
(less all accrued fees and expenses relating thereto) attributable to asset dispositions other than in the ordinary course of business, as determined in good faith by the Company, shall be excluded, 

(e) the Net Income for such period of any Person that is not a Subsidiary, or is an Unrestricted Subsidiary, or that is
accounted for by the equity method of accounting, shall be excluded; provided, that Consolidated Net Income of such Person shall be increased by the amount of dividends or distributions or other payments that are actually paid in cash (or to
the extent converted into cash) to such Person or a Subsidiary thereof that is the Company or a Restricted Subsidiary in respect of such period, 

(f) solely for the purpose of determining the amount available for Restricted Payments under clause (3) of the first
paragraph of Section 4.7, the Net Income for such period of any Restricted Subsidiary (other than any Guarantor) shall be excluded if the declaration or payment of dividends or similar distributions by that Restricted Subsidiary of its
Net Income is not at the date of determination wholly permitted without any prior governmental approval (which has not been obtained) or, directly or indirectly, by the operation of the terms of its charter or any agreement, instrument, judgment,
decree, order, statute, rule, or governmental regulation applicable to that Restricted Subsidiary or its stockholders, unless such restriction with respect to the payment of dividends or similar distributions has been legally waived;
provided, that Consolidated Net Income of the Company will be increased by the amount of dividends or other distributions or other payments actually paid in cash (or to the extent converted into cash) to the Company or a Restricted Subsidiary
thereof in respect of such period, to the extent not already included therein, 
 (g) effects of purchase accounting
adjustments (including the effects of such adjustments pushed down to such Person and such Subsidiaries) in component amounts required or permitted by GAAP, resulting from the application of purchase accounting in relation to any consummated
acquisition or the amortization or write-up, write-down or write-off of any amounts thereof, net of taxes, shall be excluded, 

(h) any pro forma after-tax effect (using a reasonable estimate based on applicable tax rates) of income (loss)
from the early extinguishment of Indebtedness or Hedging Obligations or other derivative instruments or any unrealized gains and losses from Hedging Obligations shall be excluded, 

  
 -8- 

 (i) any pro forma after-tax effect (using a reasonable estimate
based on applicable tax rates) impairment charge or asset write-off, write-up or write-down, in each case, pursuant to GAAP and the amortization of intangibles arising (including goodwill and organizational costs) pursuant to GAAP shall be excluded,

 (j) any pro forma after-tax effect (using a reasonable estimate based on applicable tax rates) non-cash
compensation expense recorded from grants of stock appreciation or similar rights, stock options, restricted stock or other rights shall be excluded, 

(k) any fees and expenses incurred during such period, or any amortization thereof for such period, in connection with any
acquisition, Investment, Disposition, dividend or similar Restricted Payments, issuance or repayment of Indebtedness, issuance of Equity Interests, refinancing or recapitalization transaction or amendment or modification of any debt instrument (in
each case, including any such transaction consummated prior to the Issue Date and any such transaction undertaken but not completed) and any charges or non-recurring merger costs incurred during such period as a result of any such transaction shall
be excluded, and 
 (l) any foreign currency translation gains or losses (including gains and losses relating to
market-to-market of Indebtedness denominated in foreign currencies) shall be excluded. 
 Notwithstanding the foregoing, for the purpose of
Section 4.7 only, there shall be excluded from Consolidated Net Income any income arising from any sale or other disposition of Restricted Investments made by the Company and its Restricted Subsidiaries, any repurchases and redemptions
of Restricted Investments made by the Company and its Restricted Subsidiaries, any repayments of loans and advances which constitute Restricted Investments made by the Company and any Restricted Subsidiary, any sale of the stock of an Unrestricted
Subsidiary or any distribution or dividend from an Unrestricted Subsidiary, in each case only to the extent such amounts increase the amount of Restricted Payments permitted under clause (3)(d) of the first paragraph of Section 4.7.

 “Contingent Obligations” means, with respect to any Person, any obligation of such Person guaranteeing or having the
economic effect of guaranteeing any leases, dividends or other obligations that do not constitute Indebtedness (“primary obligations”) of any other Person (the “primary obligor”) in any manner, whether directly or
indirectly, including, without limitation, any obligation of such Person, whether or not contingent, (i) to purchase any such primary obligation or any property constituting direct or indirect security therefor, (ii) to advance or supply
funds (A) for the purchase or payment of any such primary obligation or (B) to maintain working capital or equity capital of the primary obligor or otherwise to maintain the net worth or solvency of the primary obligor, or (iii) to
purchase property, securities or services primarily for the purpose of assuring the owner of any such primary obligation of the ability of the primary obligor to make payment of such primary obligation against loss in respect thereof or (iv) as
an account party with respect of any letter of credit, letter of guaranty or bankers’ acceptance. 
 “Continuing
Directors” means, as of any date of determination, individuals who (i) were members of such Board of Directors on the Issue Date or (ii) were either (x) nominated for election or elected to such Board of Directors with the
approval of a majority of the Continuing Directors who were members of such Board of Directors at the time of nomination or election, (y) appointed, approved or recommended by a majority of the then Continuing Directors or (z) designated
or appointed by a Permitted Holder. 

  
 -9- 

 “Contribution Indebtedness” means Indebtedness of the Company or any Guarantor
in an aggregate principal amount not greater than two times the aggregate amount of cash contributions (other than Excluded Contributions) made to the capital of the Company or such Guarantor after the Issue Date; provided that: 

(a) if the aggregate principal amount of such Contribution Indebtedness is greater than one times such cash contribution amount
to the capital of the Company or such Guarantor, as applicable, the amount of such excess shall be (i) Subordinated Indebtedness (other than Secured Indebtedness) and (ii) Indebtedness with a Stated Maturity later than the Stated Maturity
of the Notes, and 
 (b) such cash contribution amount is not applied to make Restricted Payments. 

“Corporate Trust Office of the Trustee” shall be at the address of the Trustee specified in Section 12.2 hereof
or such other address as to which the Trustee shall specify for receipt of notices under this Indenture. 
 “Credit
Agreement” means that certain Credit Agreement, dated as of June 29, 2007 (as amended by Amendment No. 1 to the Credit Agreement, dated June 4, 2012, and Amendment No. 2 to the Credit Agreement, dated January 29,
2014), among the Company, Bank of America, N.A. as Administrative Agent, Goldman Sachs Credit Partners L.P., as Syndication Agent, the agents and lenders party thereto and certain other parties specified therein, including any related notes,
guarantees, collateral documents, instruments and agreements executed in connection therewith, and in each case as amended, restated, supplemented, modified, renewed, refunded, replaced (whether at maturity or thereafter) or refinanced from time to
time in one or more agreements or indentures (in each case with the same or new agents, lenders or institutional investors), including any agreement adding or changing the borrower or any guarantor or extending the maturity thereof or otherwise
restructuring all or any portion of the Indebtedness thereunder or increasing the amount loaned or issued thereunder or altering the maturity thereof (provided that such increase in borrowings is permitted under Section 4.9). 

“Credit Facilities” means, with respect to the Company, one or more debt facilities (including, without limitation, the
Credit Agreement) or commercial paper facilities or Debt Issuances, in each case, with banks, investment banks, insurance companies, mutual funds and/or other institutional lenders or investors providing for revolving credit loans, term loans,
receivables or inventory financing (including through the sale of receivables or inventory to such lenders or to special purpose entities formed to borrow from (or sell receivables to) such lenders against such receivables or inventory) or letters
of credit or Debt Issuances, in each case, as amended, restated, modified, renewed, refunded, replaced, supplemented or refinanced, including refinancing with Debt Issuances, in whole or in part and without limitation as to amounts, terms,
conditions, covenants and other provisions, from time to time. Indebtedness under Credit Facilities outstanding on the date on which the Notes are first issued and authenticated under this Indenture (after giving effect to the use of proceeds
thereof) shall be deemed to have been incurred on such date in reliance on the exception provided by clause (1) of the second paragraph of Section 4.9. 

“Debt Issuances” means, with respect to the Company or any Restricted Subsidiary, one or more issuances after the Issue Date
of Indebtedness evidenced by notes, debentures, bonds or other similar securities or instruments. 
 “Default” means any
event that is, or with the passage of time or the giving of notice or both would be, an Event of Default. 

  
 -10- 

 “Designated Non-cash Consideration” means the fair market value of non-cash
consideration received by the Company or any of its Restricted Subsidiaries in connection with an Asset Sale that is so designated as Designated Non-cash Consideration pursuant to an Officers’ Certificate setting forth the basis of such
valuation, less the amount of cash or Cash Equivalents received in connection with a subsequent sale of such Designated Non-cash Consideration. 

“Designated Preferred Stock” means Preferred Stock of the Company or any direct or indirect parent company of the Company
(other than Disqualified Stock of the Company), that is issued for cash (other than to Parent or any of its Subsidiaries or an employee stock ownership plan or trust established by the Company or any of its Subsidiaries) and is so designated as
Designated Preferred Stock, pursuant to an Officers’ Certificate, on the issuance date thereof, the cash proceeds of which are excluded from the calculation set forth in clause (3) of the first paragraph of Section 4.7. 

“Disqualified Stock” means, with respect to any Person, any Capital Stock of such Person which, by its terms (or by the terms
of any security into which it is convertible or for which it is putable or exchangeable), or upon the happening of any event, matures or is mandatorily redeemable (other than as a result of a change of control or asset sale), pursuant to a sinking
fund obligation or otherwise, or is redeemable at the option of the holder thereof (other than as a result of a change of control or asset sale), in whole or in part, in each case prior to the earlier of the final maturity date of the Notes or the
date the Notes are no longer outstanding; provided, however, that if such Capital Stock is issued to any plan for the benefit of employees of the Company or any of its Subsidiaries or by any such plan to such employees, such Capital
Stock shall not constitute Disqualified Stock solely because it may be required to be repurchased by the Company or any of its Subsidiaries in order to satisfy applicable statutory or regulatory obligations. 

“Domestic Subsidiaries” means, with respect to any Person, any subsidiary of such Person other than a Foreign Subsidiary.

 “EBITDA” means, with respect to any Person for any period, the Consolidated Net Income of such Person and its Restricted
Subsidiaries for such period 
 (a) increased (without duplication) by: 

(i) provision for taxes based on income or profits or capital (or any alternative tax in lieu thereof), including, without
limitation, foreign, state, franchise and similar taxes and foreign withholding taxes of such Person and such subsidiaries paid or accrued during such period deducted (and not added back) in computing Consolidated Net Income, including payments made
pursuant to any tax sharing agreements or arrangements among the Company, its Restricted Subsidiaries and any direct or indirect parent company of the Company (so long as such tax sharing payments are attributable to the operations of the Company
and its Restricted Subsidiaries); plus 
 (ii) Fixed Charges of such Person and such subsidiaries for such period to
the extent the same was deducted (and not added back) in calculating such Consolidated Net Income; plus 
 (iii)
Consolidated Depreciation and Amortization Expense of such Person and such subsidiaries for such period to the extent the same were deducted (and not added back) in computing Consolidated Net Income; plus 

  
 -11- 

 (iv) any fees, costs, commissions, expenses or other charges (other than
Depreciation or Amortization Expense) related to any Equity Offering, Permitted Investment, acquisition, disposition, recapitalization or the incurrence or repayment of Indebtedness permitted to be incurred under the Indenture (including a
refinancing thereof) (whether or not successful), including (v) any expensing of bridge, commitment or other financing fees, (w) such fees, costs, commissions, expenses or other charges related to the offering of the Notes and the other
Transactions, (x) such fees, costs, commissions, expenses or other charges related to the initial public offering of VWR Corporation (y) any such fees, costs (including call premium), commissions, expenses or other charges related to any
amendment or other modification of Indebtedness permitted to be incurred hereunder, including the Existing Notes, the Notes and the Credit Facilities and (z) commissions, discounts, yield and other fees and charges (including any interest
expense) related to any Receivables Facility, and, in each case, deducted (and not added back) in computing Consolidated Net Income; plus 

(v) the amount of any business optimization expense and restructuring charge or reserve deducted (and not added back) in such
period in computing Consolidated Net Income, including any restructuring costs incurred in connection with acquisitions after the Issue Date, costs related to the closure and/or consolidation of facilities, retention charges, contract termination
costs, future lease commitments, systems establishment costs, conversion costs and excess pension charges, consulting fees and any one-time expense relating to enhanced accounting function, or costs associated with becoming a stand-alone entity or
public company incurred in connection with any of the foregoing; provided that the aggregate amount of expenses added pursuant to this clause (v) shall not exceed an amount equal to 10% of EBITDA of the Company for the period of four
consecutive fiscal quarters most recently ended prior to the determination date (without giving effect to any adjustments pursuant to this clause (v) or clause (xii) below); plus 

(vi) any other non-cash charges, expenses or losses including any write-offs or write-downs and any non-cash expense relating
to the vesting of warrants, reducing Consolidated Net Income for such period (provided that if any such non-cash charges represent an accrual or reserve for potential cash items in any future period, the cash payment in respect thereof in
such future period shall be subtracted from EBITDA in such future period to the extent paid, and excluding amortization of a prepaid cash item that was paid in a prior period); plus 

(vii) the amount of any minority interest expense consisting of subsidiary income attributable to minority equity interests of
third parties in any non-Wholly Owned Subsidiary deducted (and not added back) in such period in calculating Consolidated Net Income; plus 

(viii) [reserved]; plus 

(ix) the amount of loss on sale of receivables and related assets to the Receivables Subsidiary in connection with a
Receivables Facility deducted (and not added back) in computing Consolidated Net Income; plus 
 (x) costs or expense
deducted (and not added back) in computing Consolidated Net Income by such Person or any such subsidiary pursuant to any management equity plan or stock option plan or any other management or employee benefit plan or

  
 -12- 

 
agreement or any stock subscription or shareholder agreement, to the extent that such cost or expenses are funded with cash proceeds contributed to the capital of the Company or net cash proceeds
of an issuance of Equity Interest of the Company (other than Disqualified Stock) solely to the extent that such net cash proceeds are excluded from the calculation of the amount available for Restricted Payments under clause (3) of the first
paragraph of Section 4.7; plus 
 (xi) [reserved]; plus 

(xii) the amount of net cost savings and acquisition synergies projected by the Company in good faith to be realized during
such period (calculated on a pro forma basis as though such cost savings had been realized on the first day of such period) as a result of specified actions taken or initiated in connection with any acquisition or disposition by the Company or any
Restricted Subsidiary, net of the amount of actual benefits realized during such period that are otherwise included in the calculation of EBITDA from such actions; provided that (A) such cost savings are reasonably identifiable and
factually supportable as evidenced in an Officers Certificate, (B) such actions are taken within 18 months after the Issue Date or the date of such acquisition or disposition and (C) the aggregate amount of cost savings added pursuant to
this clause (xii) shall not exceed an amount equal to the greater of (x) $45.0 million and (y) 10% of EBITDA of the Company for the period of four consecutive fiscal quarters most recently ended prior to the determination date
(without giving effect to any adjustments pursuant to clause (v) above or this clause (xii)); plus 
 (xiii) any
net after-tax non-recurring, extraordinary or unusual gains or losses (less all fees and expenses relating thereto) or expenses; plus 

(xiv) to the extent covered by insurance and actually reimbursed or otherwise paid, or, so long as the Company has made a
determination that there exists reasonable evidence that such amount will in fact be reimbursed or otherwise paid by the insurer and only to the extent that such amount is (A) not denied by the applicable carrier in writing within 180 days and
(B) in fact reimbursed or otherwise paid within 365 days of the date of such evidence (with a deduction for any amount so added back to the extent not so reimbursed or otherwise paid within such 365 days), expenses with respect to liability or
casualty events and expenses or losses relating to business interruption; plus 
 (xv) expenses to the extent covered
by contractual indemnification or refunding provisions in favor of the Company or a Restricted Subsidiary and actually paid or refunded, or, so long as the Company has made a determination that there exists reasonable evidence that such amount will
in fact be paid or refunded by the indemnifying party or other obligor and only to the extent that such amount is (A) not denied by the applicable indemnifying party or obligor in writing within 90 days and (B) in fact reimbursed within
180 days of the date of such evidence (with a deduction for any amount so added back to the extent not so reimbursed within such 180 days); plus 

(xvi) any non-cash increase in expenses resulting from the revaluation of inventory (including any impact of changes to
inventory valuation policy methods including changes in capitalization of variances); 
 (b) decreased by (without
duplication) (i) non-cash gains increasing Consolidated Net Income of such Person and such subsidiaries for such period, excluding any non-cash gains to 

  
 -13- 

 
the extent they represent the reversal of an accrual or reserve for a potential cash item that reduced EBITDA in any prior period and (ii) the minority interest income consisting of
subsidiary losses attributable to minority equity interests of third parties in any non-Wholly Owned Subsidiary to the extent such minority interest income is included in Consolidated Net Income; and 

(c) increased or decreased by (without duplication): 

(i) any net gain or loss resulting in such period from Hedging Obligations and the application of Statement of Financial
Accounting Standards No. 133 and International Accounting Standards No. 39 and their respective related pronouncements and interpretations; plus or minus, as applicable, 

(ii) any net gain or loss included in calculating Consolidated Net Income resulting in such period from currency translation
gains or losses related to currency remeasurements of indebtedness (including any net loss or gain resulting from hedge agreements for currency exchange risk). 

“Equity Interests” means Capital Stock and all warrants, options or other rights to acquire Capital Stock (but excluding any
debt security that is convertible into, or exchangeable for, Capital Stock). 
 “Equity Offering” means any public or
private sale of Common Stock or Preferred Stock of the Company or any of its direct or indirect parent companies (excluding Disqualified Stock of such entity), other than (i) public offerings with respect to Common Stock of the Company or of
any of its direct or indirect parent companies registered on Form S-4 or Form S-8, (ii) any such public or private sale that constitutes an Excluded
Contribution or (iii) an issuance to any Subsidiary of the Company. 
 “Euroclear” means Euroclear Bank SA/NV, as
operator of the Euroclear system and any successor thereto. 
 “Exchange Act” means the Securities Exchange Act of 1934, as
amended, and the rules and regulations of the Commission promulgated thereunder. 
 “Excluded Contribution” means net
cash proceeds, marketable securities or Qualified Proceeds, in each case received by the Company and its Restricted Subsidiaries from: 

(a) contributions to its common equity capital; and 

(b) the sale (other than to a Subsidiary or to any management equity plan or stock option plan or any other management or
employee benefit plan or agreement of the Company or any Subsidiary) of Capital Stock (other than Disqualified Stock and Designated Preferred Stock), 
 in
each case designated as Excluded Contributions pursuant to an Officers’ Certificate on the date such capital contributions are made or the date such Equity Interests are sold, as the case may be, which are excluded from the calculation set
forth in clause (3) of the first paragraph of Section 4.7. 
 “Existing Notes” means the Company’s
$750.0 million aggregate principal amount of 7.25% Senior Notes due 2017. 
 “Expiration Date” has the meaning set forth in
the definition of “Offer to Purchase.” 

  
 -14- 

 “Fall Away Event” means such time following the Issue Date as (i) the Notes
shall have an Investment Grade Rating by both Rating Agencies and the Company shall have delivered to the Trustee an officers’ certificate certifying that the foregoing condition has been satisfied and (ii) no Default has occurred and is
continuing under this Indenture. 
 “Fixed Charge Coverage Ratio” means, with respect to any Person for any period
consisting of such Person and its Restricted Subsidiaries’ most recently ended four fiscal quarters for which internal financial statements are available, the ratio of EBITDA of such Person for such period to the Fixed Charges of such Person
for such period. In the event that the Company or any Restricted Subsidiary incurs, assumes, guarantees or repays any Indebtedness or issues or redeems Disqualified Stock or Preferred Stock, in each case subsequent to the commencement of the period
for which the Fixed Charge Coverage Ratio is being calculated but prior to the event for which the calculation of the Fixed Charge Coverage Ratio is made (the “Calculation Date”), then the Fixed Charge Coverage Ratio shall be
calculated giving pro forma effect to such incurrence, assumption, guarantee or repayment of Indebtedness, or such issuance or redemption of Disqualified Stock or Preferred Stock, as if the same had occurred at the beginning of the applicable
four-quarter period and as if the Company or Restricted Subsidiary had not earned the interest income actually earned during such period in respect of such cash used to repay, repurchase, defease or otherwise discharge such Indebtedness; provided,
however, that the pro forma calculation shall not give effect to any Indebtedness incurred on such date of determination pursuant to the provisions described in the second paragraph of Section 4.9, other than clause (15) thereof.

 If Investments, acquisitions, dispositions, mergers or consolidations have been made by the Company or any Restricted Subsidiary during
the four-quarter reference period or subsequent to such reference period and on or prior to or simultaneously with the Calculation Date, then the Fixed Charge Coverage Ratio shall be calculated on a pro forma basis assuming that all such
Investments, acquisitions, dispositions, mergers or consolidations (and the change in any associated Fixed Charge obligations and the change in EBITDA resulting therefrom) had occurred on the first day of the four-quarter reference period. 

If since the beginning of such period any Person (that subsequently became a Restricted Subsidiary or was merged with or into the Company or
any Restricted Subsidiary since the beginning of such period) shall have made any Investment, acquisition, disposition, merger or consolidation that would have required adjustment pursuant to this definition, then the Fixed Charge Coverage Ratio
shall be calculated giving pro forma effect thereto for such period as if such Investment, acquisition, disposition, merger or consolidation had occurred at the beginning of the applicable four-quarter period. 

For purposes of this definition, whenever pro forma effect is to be given to an Investment, acquisition, disposition, merger or consolidation
and the amount of income or earnings relating thereto, the pro forma calculations shall be determined in good faith by a responsible financial or accounting Officer of the Company and shall comply with the requirements of Rule 11-02 of Regulation S-X promulgated by the Commission, except that such pro forma calculations may include operating expense reductions for such period resulting from the transaction which is being given
pro forma effect that (A) have been realized or (B) for which the steps necessary for realization have been taken (or are taken concurrently with such transaction) or (C) for which the steps necessary for realization are reasonably
expected to be taken within the 18-month period following such transaction and, in each case, including, but not limited to, (a) reduction in personnel expenses, (b) reduction of costs related to administrative functions,
(c) reduction of costs related to leased or owned properties and (d) reductions from the consolidation of operations and streamlining of corporate overhead; provided that, in each case, such adjustments are set forth in an
Officers’ Certificate signed by the Company’s chief financial officer and another Officer which states (i) the amount of such adjustment or adjustments, (ii) in the case of items (B) or (C) above, that such adjustment
or adjustments are based on the reasonable good faith beliefs of the Officers executing 

  
 -15- 

 
such Officers’ Certificate at the time of such execution and (iii) that any related incurrence of Indebtedness is permitted pursuant to this Indenture. If any Indebtedness bears a
floating rate of interest and is being given pro forma effect, the interest on such Indebtedness shall be calculated as if the rate in effect on the Calculation Date had been the applicable rate for the entire period (taking into account any Hedging
Obligations applicable to such Indebtedness if the related hedge has a remaining term in excess of twelve months). 
 Interest on a
Capitalized Lease Obligation shall be deemed to accrue at the interest rate reasonably determined by a responsible financial or accounting officer of the Company to be the rate of interest implicit in such Capitalized Lease Obligation in accordance
with GAAP. For purposes of making the computation referred to above, interest on any Indebtedness under a revolving credit facility computed on a pro forma basis shall be computed based upon the average daily balance of such Indebtedness during the
applicable period. Interest on Indebtedness that may optionally be determined at an interest rate based upon a factor of a prime or similar rate, a eurocurrency interbank offered rate, or other rate, shall be deemed to have been based upon the rate
actually chosen, or, if none, then based upon such optional rate chosen as the Company may designate. 
 “Fixed Charges”
means, with respect to any Person for any period, the sum of, without duplication, (a) Consolidated Interest Expense (excluding all non-cash interest expense and amortization/accretion of original issue discount (including any original issue
discount created by fair value adjustments to Indebtedness in existence as of the Issue Date as a result of purchase accounting)) of such Person for such period, (b) all cash dividends paid during such period (excluding items eliminated in
consolidation) on any series of Preferred Stock of such Person and its Subsidiaries and (c) all dividends paid during such period (excluding items eliminated in consolidation) on any series of Disqualified Stock of such Person and its
Subsidiaries. 
 “Foreign Subsidiary” means, with respect to any Person, (a) any subsidiary of such Person that is
organized and existing under the laws of any jurisdiction outside the United States of America or (b) any subsidiary of such Person that has no material assets other than the Capital Stock of one or more subsidiaries described in clause
(a) and other assets relating to an ownership interest in any such Capital Stock or subsidiaries. 
 “GAAP” means
generally accepted accounting principles in the United States in effect on the date of this Indenture, except for any reports required to be delivered pursuant to Section 4.3, which shall be prepared in accordance with GAAP in effect on
the date thereof, except as provided below. At any time after adoption of IFRS by the Company for its financial statements and reports for all financial reporting purposes, the Company may elect to apply IFRS for all purposes of this Indenture, in
lieu of United States GAAP, and, upon any such election, references herein to GAAP shall be construed to mean IFRS as in effect on the date of the election (except for any reports required to be delivered under Section 4.3, which shall
be prepared in accordance with IFRS in effect on the date thereof) from time to time; provided that (1) any such election once made shall be irrevocable (and shall only be made once), (2) all financial statements and reports
required to be provided after such election pursuant to this Indenture shall be prepared on the basis of IFRS and (3) from and after such election, all ratios, computations and other determinations (A) based on GAAP contained in this
Indenture shall be computed in conformity with IFRS and (B) in this Indenture that require the application of GAAP for periods that include fiscal quarters ended prior to the Company’s election to apply IFRS shall remain as previously
calculated or determined in accordance with GAAP. The Company shall give notice of any election to the Trustee and the holders of Notes with 15 days of such election. For the avoidance of doubt, solely making an election (without any other action)
referred to in this definition will not be treated as an incurrence of Indebtedness. For purposes of this Indenture, the term “consolidated” with respect to any Person means such Person consolidated with its Restricted Subsidiaries and
does not include any Unrestricted Subsidiary. 

  
 -16- 

 “Global Note Legend” means the legend identified as such in
Exhibit A hereto. 
 “Global Notes” means the Notes that are in the form of Exhibit A hereto issued
in global form and registered in the name of the Common Depositary or its nominee. Notwithstanding anything to the contrary contained herein, notices, delivery and payment with respect to the Global Notes will be through the Common Depositary. 

“Government Securities” means any security that is (1) a direct obligation of any country that is a member of the
European Monetary Union whose long-term debt is rated “A-1” or higher by Moody’s or “A+” or higher by S&P or the equivalent rating category of another internationally recognized rating agency on the date hereof, for the
payment of which the full faith and credit of such country is pledged or (2) an obligation of a person controlled or supervised by and acting as an agency or instrumentality of any such country the payment of which is unconditionally guaranteed
as a full faith and credit obligation by such country, which, in either case under the preceding clause (1) or (2), is not callable or redeemable at the option of the issuer thereof. 

“guarantee” means a guarantee other than by endorsement of negotiable instruments for collection in the ordinary course of
business, direct or indirect, in any manner including, without limitation, through letters of credit or reimbursement agreements in respect thereof, of all or any part of any Indebtedness or other obligations. When used as a verb,
“guarantee” shall have a corresponding meaning. 
 “Guarantee” means any guarantee of the obligations of the
Company under this Indenture and the Notes by a Guarantor in accordance with the provisions of this Indenture. When used as a verb, “Guarantee” shall have a corresponding meaning. 

“Guarantor” means any Person that incurs a Guarantee of the Notes; provided that upon the release and discharge of
such Person from its Guarantee in accordance with this Indenture, such Person shall cease to be a Guarantor. On the Issue Date, the Guarantors will be each Domestic Subsidiary of the Company that is a Restricted Subsidiary and a guarantor under the
Credit Agreement. 
 “Hedging Obligations” means, with respect to any Person, the obligations of such Person under: 

(a) currency exchange, interest rate or commodity swap agreements, currency exchange, interest rate or commodity cap agreements
and currency exchange, interest rate or commodity collar agreements; and 
 (b) other agreements or arrangements designed to
manage, hedge or protect such Person with respect to fluctuations in currency exchange, interest rates or commodity, raw materials, utilities and energy prices. 

“Holder” means a Person in whose name a Note is registered in the security register. 

“IFRS” means the International Financial Reporting Standards as issued by the International Accounting Standards Board. 

“Income Tax Receivable Agreement” means the Income Tax Receivable Agreement, dated as of October 7, 2014, by and between
VWR Corporation and Varietal Distribution Holdings, LLC. 

  
 -17- 

 “Indebtedness” means, with respect to any Person, 

(a) any indebtedness (including principal and premium) of such Person, whether or not contingent: 

(i) in respect of borrowed money, 

(ii) evidenced by bonds, notes, debentures or similar instruments, 

(iii) evidenced by letters of credit (or, without duplication, reimbursement agreements in respect thereof), 

(iv) Capitalized Lease Obligations, 

(v) representing the deferred and unpaid balance of the purchase price of any property (other than Capitalized Lease
Obligations), except (A) any such balance that constitutes a trade payable or similar obligation to a trade creditor in each case accrued in the ordinary course of business, (B) liabilities accrued in the ordinary course of business and
(C) earn-outs and other contingent payments in respect of acquisitions except to the extent that the liability on account of any such earn-outs or contingent payment becomes fixed, or 

(vi) representing any interest rate Hedging Obligations, 

if and to the extent that any of the foregoing Indebtedness (other than letters of credit and Hedging Obligations) would appear as a liability
upon a balance sheet (excluding the footnotes thereto) of such Person prepared in accordance with GAAP, 
 (b) to the extent
not otherwise included, any obligation by such Person to be liable for, or to pay, as obligor, guarantor or otherwise, the Indebtedness of another Person (other than by endorsement of negotiable instruments for collection in the ordinary course of
business), 
 (c) Disqualified Stock of such Person, and 

(d) to the extent not otherwise included, Indebtedness of another Person secured by a Lien on any asset (other than a Lien on
Capital Stock of an Unrestricted Subsidiary) owned by such Person (whether or not such Indebtedness is assumed by such Person); 
 provided,
however, that notwithstanding the foregoing, Indebtedness shall be deemed not to include (A) Contingent Obligations incurred in the ordinary course of business, (B) items that would appear as a liability on a balance sheet prepared
in accordance with GAAP as a result of the application of EITF 97-10, “The Effect of Lessee Involvement in Asset Construction,” and (C) obligations with respect to Receivables Facilities. The
amount of Indebtedness of any person under clause (d) above shall be deemed to equal the lesser of (x) the aggregate unpaid amount of such Indebtedness secured by such Lien and (y) the fair market value of the property encumbered
thereby as determined by such person in good faith. 
 “Indenture” means this Indenture, as amended or supplemented from
time to time. 
 “Independent Financial Advisor” means an accounting, appraisal or investment banking firm or consultant of
nationally recognized standing that is, in the good faith judgment of the Board of Directors of the Company, qualified to perform the task for which it has been engaged. 

  
 -18- 

 “Initial Notes” has the meaning set forth in the preamble hereto. 

“Investment Grade Rating” means a rating equal to or higher than Baa3 (or the equivalent) by Moody’s and BBB- (or the
equivalent) by S&P, or an equivalent rating by any other Rating Agency. 
 “Investment Grade Securities” means: 

(a) securities issued or directly and fully guaranteed or insured by the United States government or any agency or
instrumentality thereof (other than Cash Equivalents); 
 (b) debt securities or debt instruments with an Investment Grade
Rating, but excluding any debt securities or instruments constituting loans or advances among the Company and its Subsidiaries; 

(c) investments in any fund that invests exclusively in investments of the type described in clauses (a) and
(b) which fund may also hold immaterial amounts of cash pending investment or distribution; and 
 (d) corresponding
instruments in countries other than the United States customarily utilized for high quality investments. 
 “Investments”
means, with respect to any Person, all direct or indirect investments by such Person in other Persons (including Affiliates) in the forms of loans (including guarantees or other obligations), advances or capital contributions (including by means of
any transfer of cash or other property to others or any payment for property or services for the account or use of others, but excluding accounts receivable, trade credit, advances to customers, commission, travel, entertainment, relocation, payroll
and similar advances to officers and employees, in each case made in the ordinary course of business), purchases or other acquisitions for consideration of Indebtedness, Equity Interests or other securities issued by any other Person and investments
that are required by GAAP to be classified on the balance sheet (excluding the footnotes) of such Person in the same manner as the other investments included in this definition to the extent such transactions involve the transfer of cash or other
property. If the Company or any Subsidiary of the Company sells or otherwise disposes of any Equity Interests of any direct or indirect Restricted Subsidiary of the Company such that, after giving effect to any such sale or disposition, such Person
is no longer a Subsidiary of the Company, the Company will be deemed to have made an Investment on the date of any such sale or disposition equal to the fair market value of the Equity Interests of such Subsidiary not sold or disposed of in an
amount determined as provided in the third paragraph of Section 4.7. 
 For purposes of the definition of “Unrestricted
Subsidiary” and Section 4.7, (i) “Investments” shall include the portion (proportionate to the Company’s equity interest in such Subsidiary) of the fair market value of the net assets of a Subsidiary of the
Company at the time that such Subsidiary is designated an Unrestricted Subsidiary; provided, however, that upon a redesignation of such Subsidiary as a Restricted Subsidiary, the Company shall be deemed to continue to have a permanent
“Investment” in an Unrestricted Subsidiary in an amount (if positive) equal to (x) the Company’s “Investment” in such Subsidiary at the time of such redesignation less (y) the portion (proportionate to the
Company’s equity interest in such Subsidiary) of the fair market value of the net assets of such Subsidiary at the time of such redesignation; (ii) any property transferred to or from an Unrestricted Subsidiary shall be valued at its fair
market value at the time of such transfer, in each case as determined in good faith by the Board of Directors of the Company and (iii) any transfer of Capital Stock that results in an entity which became a Restricted Subsidiary after the Issue
Date ceasing to be a Restricted Subsidiary shall be deemed to be an Investment in an amount equal to the fair market value (as determined by the Board of Directors of the Company in good faith as of the date of initial acquisition) of the Capital
Stock of such entity owned by the Company and its Restricted Subsidiaries immediately after such transfer. 

  
 -19- 

 “Issue Date” means March 25, 2015. 

“Lien” means, with respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in
respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law, including any conditional sale or other title retention agreement, any lease in the nature thereof, and any agreement to give a security interest in
such asset; provided that in no event shall an operating lease be deemed to constitute a Lien. 
 “Moody’s”
means Moody’s Investors Service, Inc. and any successor to its rating business. 
 “Net Income” means, with
respect to any Person, the net income (loss) of such Person, determined in accordance with GAAP and before any reduction in respect of Preferred Stock dividends or accretion of any Preferred Stock. 

“Net Proceeds” means with respect to any Asset Sale, the proceeds thereof in the form of cash and Cash Equivalents (including
any such proceeds subsequently received (as and when received) in respect of deferred payments or noncash consideration initially received, net of any costs relating to the disposition thereof), net of (i) out-of-pocket expenses incurred
(including reasonable and customary brokers’ fees or commissions, investment banking, consultant, legal, accounting or similar fees, survey costs, title insurance premiums, and related search and recording charges, transfer, deed, recording and
similar taxes incurred by the Company and its Restricted Subsidiaries in connection therewith), and the Company’s good faith estimate of taxes paid or payable (including payments under any tax sharing agreement or arrangement), in connection
with such Asset Sale (including, in the case of any such Asset Sale in respect of property of any Foreign Subsidiary, taxes payable upon the repatriation of any such proceeds), (ii) amounts provided as a reserve, in accordance with GAAP,
against any (x) liabilities under any indemnification obligations or purchase price adjustment associated with such Asset Sale and (y) other liabilities associated with the asset disposed of and retained by the Company or any of its
Restricted Subsidiaries after such disposition, including pension and other post-employment benefit liabilities and liabilities related to environmental matters (provided that to the extent and at the time any such amounts are released from
such reserve, such amounts shall constitute Net Proceeds), (iii) the principal amount, premium or penalty, if any, interest and other amounts on any Indebtedness or other obligation which is secured by a Lien on the asset sold and (iv) in
the case of any such Asset Sale by a non-Wholly Owned Restricted Subsidiary, the pro rata portion of the Net Proceeds thereof (calculated without regard to this clause (iv)) attributable to minority interests and not available for distribution to or
for the account of the Company or a Wholly Owned Restricted Subsidiary as a result thereof. 
 “Notes” means the 4.625%
Senior Notes due 2022 of the Company issued on the date hereof and any Additional Notes. The Notes and the Additional Notes, if any, shall be treated as a single class for all purposes under this Indenture. 

“Obligations” means any principal, interest, premium, penalties, fees, indemnifications, reimbursements (including, without
limitation, reimbursement obligations with respect to letters of credit), costs, expenses, damages and other liabilities, and guarantees of payment of such principal, interest, premium, penalties, fees, indemnifications, reimbursements, costs,
expenses, damages and other liabilities, payable under the documentation governing any Indebtedness. 
 “Offer” has the
meaning set forth in the definition of “Offer to Purchase.” 

  
 -20- 

 “Offer to Purchase” means a written offer (the “Offer”) sent by
the Company by first class mail, postage prepaid, to each Holder at his address appearing in the security register on the date of the Offer, offering to purchase up to the aggregate principal amount of Notes set forth in such Offer at the purchase
price set forth in such Offer (as determined pursuant to this Indenture). Unless otherwise required by applicable law, the Offer shall specify an expiration date (the “Expiration Date”) of the Offer to Purchase which shall be,
subject to any contrary requirements of applicable law, not less than 30 days or more than 60 days after the date of mailing of such Offer and a settlement date (the “Purchase Date”) for purchase of Notes within five
(5) Business Days after the Expiration Date. The Company shall notify the Trustee at least 15 days (or such shorter period as is acceptable to the Trustee) prior to the mailing of the Offer of the Company’s obligation to make an Offer
to Purchase, and the Offer shall be mailed by the Company or, at the Company’s request, by the Trustee in the name and at the expense of the Company. The Offer shall contain all instructions and materials necessary to enable such Holders to
tender Notes pursuant to the Offer to Purchase. The Offer shall also state: 
 (1) the Section of this Indenture pursuant to
which the Offer to Purchase is being made; 
 (2) the Expiration Date and the Purchase Date; 

(3) the aggregate principal amount of the outstanding Notes offered to be purchased pursuant to the Offer to Purchase
(including, if less than 100%, the manner by which such amount has been determined pursuant to Section 4.10 hereof or Section 4.14 hereof) (the “Purchase Amount”); 

(4) the purchase price to be paid by the Company for each €1,000 principal amount of Notes accepted for payment (as
specified pursuant to this Indenture) (the “Purchase Price”); 
 (5) that the Holder may tender all or any
portion of the Notes registered in the name of such Holder and that any portion of a Note tendered must be tendered in denominations of €100,000 principal amount or integral multiples of €1,000 thereof; 

(6) the place or places where Notes are to be surrendered for tender pursuant to the Offer to Purchase, if applicable; 

(7) that, unless the Company defaults in making such purchase, any Note accepted for purchase pursuant to the Offer to Purchase
will cease to accrue interest on and after the Purchase Date, but that any Note not tendered or tendered but not purchased by the Company pursuant to the Offer to Purchase will continue to accrue interest at the same rate; 

(8) that, on the Purchase Date, the Purchase Price will become due and payable upon each Note accepted for payment pursuant to
the Offer to Purchase; 
 (9) that each Holder electing to tender a Note pursuant to the Offer to Purchase will be required
to surrender such Note or cause such Note to be surrendered at the place or places set forth in the Offer prior to the close of business on the Expiration Date (such Note being, if the Company or the Trustee so requires, duly endorsed by, or
accompanied by a written instrument of transfer in form satisfactory to the Company and the Trustee duly executed by, the Holder thereof or his attorney duly authorized in writing); 

(10) that Holders will be entitled to withdraw all or any portion of Notes tendered if the Company (or its Paying Agent)
receives, not later than the close of business on the Expiration 

  
 -21- 

 
Date, a telegram, telex, facsimile transmission or letter setting forth the name of the Holder, the aggregate principal amount of the Notes the Holder tendered, the certificate number of the Note
the Holder tendered and a statement that such Holder is withdrawing all or a portion of his tender; 
 (11) that (a) if
Notes having an aggregate principal amount less than or equal to the Purchase Amount are duly tendered and not withdrawn pursuant to the Offer to Purchase, the Company shall purchase all such Notes and (b) if Notes having an aggregate principal
amount in excess of the Purchase Amount are tendered and not withdrawn pursuant to the Offer to Purchase, the Company shall purchase Notes having an aggregate principal amount equal to the Purchase Amount on a pro rata basis (with such
adjustments as may be deemed appropriate so that only Notes in denominations of €100,000 principal amount or integral multiples of €1,000 thereof shall be purchased); and 

(12) if applicable, that, in the case of any Holder whose Note is purchased only in part, the Company shall execute, and the
Trustee shall authenticate and deliver to the Holder of such Note without service charge, a new Note or Notes, of any authorized denomination as requested by such Holder, in the aggregate principal amount equal to and in exchange for the unpurchased
portion of the aggregate principal amount of the Notes so tendered. 
 “Offering Circular” means the final offering
circular related to the issuance of the Notes on the Issue Date, dated March 19, 2015. 
 “Officer” means the Chief
Executive Officer, the President, the Chief Financial Officer, the Chief Operating Officer, principal accounting officer, controller, any Executive Vice President, Senior Vice President or Vice President, the Treasurer or Assistant Treasurer or the
Secretary or any Assistant Secretary of the Company. 
 “Officers’ Certificate” means a certificate signed on behalf
of the Company, by two Officers of the Company, one of whom is the principal executive officer, the principal financial officer, the treasurer or the principal accounting officer of the Company that meets the requirements set forth in this
Indenture. 
 “Opinion of Counsel” means an opinion from legal counsel who is reasonably acceptable to the Trustee. The
counsel may be an employee of or counsel to the Company or any Subsidiary of the Company. 
 “Parent” means VWR Corporation
and any successor. 
 “Participant” means, with respect to Euroclear or Clearstream, a Person who has an account with
Euroclear or Clearstream, respectively. 
 “Paying Agent” means any Person authorized by the Company to pay the principal
of, premium, if any, or interest on any Notes on behalf of the Company. 
 “Permitted Asset Swap” means, to the extent
allowable under Section 1031 of the Code, the concurrent purchase and sale or exchange of Related Business Assets or a combination of Related Business Assets (excluding any boot thereon) between the Company or any of its Restricted Subsidiaries
and another Person. 
 “Permitted Business” means the business and any services, activities or businesses incidental, or
directly related or similar to, or complementary to any line of business engaged in by the Company and its Subsidiaries as of the Issue Date or any business activity that is a reasonable extension, development or expansion thereof or ancillary
thereto. 

  
 -22- 

 “Permitted Debt” has the meaning assigned to such term in
Section 4.9. 
 “Permitted Holders” means (i) the Sponsor, (ii) any Person who is an Officer, a
director or otherwise a member of management of the Company or any of its Subsidiaries on the Issue Date, provided that if such Officers, directors and members of management beneficially own more shares of Voting Stock of either of the
Company or any of its direct or indirect parent entities than the number of such shares beneficially owned by all the Officers as of the Issue Date or issued within 90 days thereafter, such excess shall be deemed not to be beneficially owned by
Permitted Holders, (iii) any Related Party of any of the foregoing Persons and (iv) any “group” (within the meaning of Section 13(d)(3) or Section 14(d)(2) of the Exchange Act or any successor provision) of
which any of the foregoing are members, provided that in the case of such “group” and without giving effect to the existence of such “group” or any other “group,” such Persons specified in clause (i),
(ii) or (iii) above (subject, in the case of Officers, to the foregoing limitation), collectively, have beneficial ownership, directly or indirectly, of more than 50% of the total voting power of the Voting Stock of the Company or any of
its direct or indirect parent entities held by such “group,” and provided further, that, in no event shall the Sponsor own a lesser percentage of the Voting Stock than any other person or group referred to in
clauses (ii) or (iii). 
 “Permitted Investments” means: 

(1) any Investment by the Company in any Restricted Subsidiary or by a Restricted Subsidiary in the Company or another
Restricted Subsidiary; 
 (2) any Investment in cash and Cash Equivalents or Investment Grade Securities; 

(3) any Investment by the Company or any Restricted Subsidiary in a Person that is engaged in a Permitted Business if as a
result of such Investment (A) such Person becomes a Restricted Subsidiary or (B) such Person, in one transaction or a series of related transactions, is merged, consolidated or amalgamated with or into, or transfers or conveys
substantially all of its assets to, or is liquidated into, the Company or a Restricted Subsidiary, and, in each case, any Investment held by such Person; provided that such Investment was not acquired by such Person in contemplation of such
acquisition, merger, consolidation or transfer; 
 (4) any Investment in securities or other assets not constituting cash or
Cash Equivalents or Investment Grade Securities and received in connection with an Asset Sale made pursuant to Section 4.10 or any other disposition of assets not constituting an Asset Sale; 

(5) any Investment existing on the Issue Date or made pursuant to binding commitments in effect on the Issue Date or an
Investment consisting of any extension, modification, replacement, renewal of any Investment existing on the Issue Date; provided that the amount of any such Investment may be increased (x) as required by the terms of such Investment as
in existence on the Issue Date or (y) as otherwise permitted under this Indenture; 
 (6) loans and advances to, or
guarantees of Indebtedness of, directors, employees, officers and consultants not in excess of $20.0 million outstanding at any one time, in the aggregate; 

(7) any Investment acquired by the Company or any Restricted Subsidiary (A) in exchange for any other Investment or
accounts receivable held by the Company or Restricted Subsidiary in connection with or as a result of a bankruptcy, workout, reorganization or recapitalization 

  
 -23- 

 
of the issuer of such other Investment or accounts receivable or (B) as a result of a foreclosure by the Company or Restricted Subsidiary with respect to any secured Investment or other
transfer of title with respect to any secured Investment in default; 
 (8) Hedging Obligations permitted under clause
(10) of the definition of “Permitted Debt”; 
 (9) loans and advances to officers, directors and employees for
business-related travel expenses, moving expenses and other similar expenses, in each case incurred in the ordinary course of business; 

(10) any Investment by the Company or a Restricted Subsidiary having an aggregate fair market value, taken together with all
other Investments made pursuant to this clause (10) that are at that time outstanding not to exceed $100.0 million (with the fair market value of each Investment being measured at the time made and without giving effect to subsequent
changes in value); provided that if such Investment is in Capital Stock of a Person that subsequently becomes a Restricted Subsidiary, such Investment shall thereafter be deemed permitted under clause (1) above and shall not be included
as having been made pursuant to this clause (10); 
 (11) Investments the payment for which consists of Equity Interests of
the Company or any of its direct or indirect parent companies (exclusive of Disqualified Stock); provided that such Equity Interests will not increase the amount available for Restricted Payments under clause (3)(b) of the first
paragraph of Section 4.7; 
 (12) guarantees (including Guarantees) of Indebtedness permitted under
Section 4.9 and performance guarantees consistent with past practice, and the creation of liens on the assets of the Company or any of its Restricted Subsidiaries in compliance with Section 4.12; 

(13) Investments consisting of licensing of intellectual property pursuant to joint marketing arrangements with other Persons;

 (14) Investments relating to a Receivables Subsidiary that, in the good faith determination of the Company, are necessary
or advisable to effect a Receivables Facility; 
 (15) Investments consisting of earnest money deposits required in
connection with a purchase agreement or other acquisition; 
 (16) any transaction to the extent it constitutes an Investment
that is permitted and made in accordance with the provisions of the second paragraph of Section 4.11, except transactions permitted by clause (2), (6), (8), (10), (12) or (13); 

(17) Investments consisting of purchases and acquisitions of inventory, supplies, material or equipment; 

(18) Investments in the ordinary course of business consisting of endorsements for collection or deposit; 

(19) additional Investments in joint ventures in an aggregate amount not to exceed $27.0 million at any time outstanding; 

  
 -24- 

 (20) loans and advances relating to indemnification or reimbursement of any
officers, directors or employees in respect of liabilities relating to their serving in any such capacity or as otherwise permitted under Section 4.11; 

(21) Investments in the nature of pledges or deposits with respect to leases or utilities provided to third parties in the
ordinary course of business; 
 (22) Investments in industrial development or revenue bonds or similar obligations secured by
assets leased to and operated by the Company or any of its Subsidiaries that were issued in connection with the financing of such assets, so long as the Company or any such Subsidiary may obtain title to such assets at any time by optionally
canceling such bonds or obligations, paying a nominal fee and terminating such financing transaction; 
 (23) deposits made
by the Company and Foreign Subsidiaries in Cash Pooling Arrangements; 
 (24) [reserved]; 

(25) Investments in (i) new offshore finance companies, including, without limitation, non-Wholly-Owned Subsidiaries and
(ii) new Foreign Subsidiaries that would engage in transactions with other Foreign Subsidiaries to maximize tax efficiency and dividend capacity; and 

(26) extensions of trade credit in the ordinary course of business. 

For purposes of this definition, in the event that a proposed Investment (or portion thereof) meets the criteria of more than one of the
categories of Permitted Investments described in clauses (1) through (18) above, or is otherwise entitled to be incurred or made pursuant to Section 4.7, the Company will be entitled to classify, or later reclassify, such
Investment (or portion thereof) in one or more of such categories set forth above or under Section 4.7. 
 “Permitted
Liens” means the following types of Liens: 
 (1) deposits of cash or government bonds made in the ordinary course
of business to secure surety or appeal bonds to which such Person is a party; 
 (2) Liens in favor of issuers of stay,
customs, performance, surety, bid, indemnity, warranty, release, appeal or similar bonds or with respect to other regulatory requirements or letters of credit or bankers’ acceptance issued, and completion guarantees provided for, in each case
pursuant to the request of and for the account of such Person in the ordinary course of its business or consistent with past practice; 

(3) Liens on property or shares of stock of a Person at the time such Person becomes a Subsidiary; provided,
however, that such Liens are not created or incurred in connection with, or in contemplation of, or to provide all or any portion of the funds or credit support utilized in connection with, such other Person becoming such a Subsidiary;
provided further, however, that such Liens may not extend to any other property owned by the Company or any Restricted Subsidiary; 

(4) Liens on property at the time the Company or a Restricted Subsidiary acquired the property, including any acquisition by
means of a merger or consolidation with or into the Company or any of its Restricted Subsidiaries; provided, however, that such Liens are not created 

  
 -25- 

 
or incurred in connection with, or in contemplation of, or to provide all or any portion of the funds or credit support utilized for, such acquisition; provided further,
however, that such Liens may not extend to any other property owned by the Company or any Restricted Subsidiary; 

(5) Liens securing Hedging Obligations so long as the related Indebtedness is permitted to be incurred under this Indenture and
is secured by a Lien on the same property securing such Hedging Obligation; 
 (6) Liens on specific items of inventory or
other goods and proceeds of any Person securing such Person’s obligations in respect of bankers’ acceptances or letters of credit issued or created for the account of such Person to facilitate the purchase, shipment or storage of such
inventory or other goods and pledges or deposits in the ordinary course of business securing inventory purchases from vendors; 

(7) Liens in favor of the Company or any Restricted Subsidiary; 

(8) Liens to secure any Indebtedness that is incurred to refinance any Indebtedness that has been secured by a Lien existing on
the Issue Date or referred to in clauses (3), (4) and (l9)(B) of this definition; provided, however, that such Liens (x) are no less favorable to the Holders of the Notes taken as a whole and (y) do not extend to or
cover any property or assets of the Company or any of its Restricted Subsidiaries not securing the Indebtedness so refinanced; 

(9) Liens on accounts receivable and related assets incurred in connection with a Receivable Facility incurred pursuant to
clause (18) of the definition of “Permitted Debt”; 
 (10) Liens for taxes, assessments or other governmental
charges or levies not overdue by more than forty-five (45) days or the nonpayment of which in the aggregate would not reasonably be expected to result in a material adverse effect, or which are being contested in good faith by appropriate
proceedings promptly instituted and diligently conducted or for property taxes on property that the Company or one of its Subsidiaries has determined to abandon if the sole recourse for such tax, assessment, charge, levy or claim is to such
property; 
 (11) judgment liens in respect of judgments that do not constitute an Event of Default; 

(12) pledges, deposits or security under workmen’s compensation, unemployment insurance and other social security laws or
regulations, or deposits to secure the performance of tenders, contracts (other than for the payment of Indebtedness) or leases, or deposits to secure public or statutory obligations, or deposits as security for contested taxes or import or customs
duties or for the payment of rent, or deposits or other security securing liabilities to insurance carriers under insurance or self-insurance arrangements or earnest money deposits required in connection with a purchase agreement or other
acquisition, in each case incurred in the ordinary course of business or consistent with past practice; 
 (13)
carriers’, warehousemen’s, mechanics’, materialmen’s, repairmen’s and other like Liens imposed by applicable law, (i) arising in the ordinary course of business and securing obligations that are not overdue by more than
sixty (60) days, (ii) (A) that are being contested in good faith by appropriate proceedings and (B) the Company or a Restricted Subsidiary has set aside on its books adequate reserves with respect thereto in accordance with GAAP
or (iii) the existence of which would not reasonably be expected to result in a material adverse effect; 

  
 -26- 

 (14) minor survey exceptions, encumbrances, ground leases, easements or
reservations of, or rights of others for, licenses, rights of way, sewers, electric lines, telegraph and telephone lines and other similar purposes, or zoning, building codes or other restrictions (including, without limitation, minor defects or
irregularities in title and similar encumbrances) as to the use of real properties or Liens incidental to the conduct of business or to the ownership of properties that do not in the aggregate materially adversely affect the value of said properties
or materially impair their use in the operation of the business; 
 (15) leases, licenses, subleases or sublicenses
(including, without limitation, licenses and sublicenses of intellectual property) granted to others in the ordinary course of business that do not interfere in any material respect with the business of the Company or any of its material Restricted
Subsidiaries or which do not by their own terms secure any Indebtedness; 
 (16) the rights reserved or vested in any Person
by the terms of any lease, license, franchise, grant or permit held by the Company or any of its Restricted Subsidiaries or by a statutory provision, to terminate any such lease, license, franchise, grant or permit, or to require annual or periodic
payments as a condition to the continuance thereof; 
 (17) banker’s Liens, rights of set-off or similar rights and
remedies as to deposit accounts or other funds maintained with a depositary institution; 
 (18) Liens arising from Uniform
Commercial Code financing statement filings regarding operating leases or consignments entered into by the Company and its Restricted Subsidiaries in the ordinary course of business; 

(19) (A) other Liens securing Indebtedness for borrowed money or other obligations with a principal amount not exceeding
$50.0 million at any time and (B) Liens securing Indebtedness incurred to finance the construction, purchase or lease of, or repairs, improvements or additions to, property of such Person; provided, however, that (x) the Lien
may not extend to any other property (except for accessions to such property) owned by such Person or any of its Restricted Subsidiaries at the time the Lien is incurred, (y) such Liens attach concurrently with or within 270 days after the
acquisition, repair, replacement, construction or improvement (as applicable) of the property subject to such Liens and (z) with respect to Capitalized Lease Obligations, such Liens do not at any time extend to or cover any assets (except for
accessions to such assets) other than the assets subject to such Capitalized Lease Obligations; provided that individual financings of property provided by one lender may be cross-collateralized to other financings of equipment provided by
such lender; 
 (20) Liens (i) of a collection bank arising under
Section 4-210 of the Uniform Commercial Code on items in the course of collection, (ii) attaching to commodity trading accounts or other commodities brokerage accounts incurred in the ordinary course
of business and (iii) in favor of a banking institution arising as a matter of law encumbering deposits (including the right of set-off) and which are within the general parameters customary in the banking industry; 

(21) Liens encumbering reasonable customary initial deposits and margin deposits and similar Liens attaching to commodity
trading accounts or other brokerage accounts incurred in the ordinary course of business and not for speculative purposes; 

(22) Liens that are contractual rights of set-off (i) relating to the establishment of depository relations with banks not
given in connection with the issuance of Indebtedness, (ii) relating to pooled deposit or sweep accounts of the Company or any Restricted Subsidiary to 

  
 -27- 

 
permit satisfaction of overdraft or similar obligations incurred in the ordinary course of business of the Company and its Restricted Subsidiaries or (iii) relating to purchase orders and
other agreements entered into by the Company or any Restricted Subsidiary in the ordinary course of business; 
 (23) Liens
solely on any cash earnest money deposits made by the Company or any of its Restricted Subsidiaries in connection with any letter of intent or purchase agreement permitted under this Indenture; 

(24) Liens with respect to the assets of a Restricted Subsidiary that is not a Guarantor securing Indebtedness of such
Restricted Subsidiary incurred in accordance with Section 4.9; 
 (25) Liens to secure Indebtedness incurred
pursuant to clauses (21) and (27) of the definition of “Permitted Debt”; 
 (26) Liens arising by
operation of law under Article 2 of the Uniform Commercial Code in favor of a reclaiming seller of goods or buyer of goods; 

(27) security given to a public or private utility or any governmental authority as required in the ordinary course of
business; 
 (28) landlords’ and lessors’ Liens in respect of rent not in default for more than sixty days or the
existence of which, individually or in the aggregate, would not reasonably be expected to result in a material adverse effect; 

(29) Liens in favor of customs and revenues authorities imposed by applicable law arising in the ordinary course of business in
connection with the importation of goods and securing obligations (i) with respect to customs duties in the ordinary course of business, (ii) that are not overdue by more than sixty (60) days, (iii) (A) that are being
contested in good faith by appropriate proceedings and (B) the Company or Restricted Subsidiary has set aside on its books adequate reserves with respect thereto in accordance with GAAP or (iv) the existence of which would not reasonably
be expected to result in a material adverse effect; 
 (30) Liens on securities which are the subject of repurchase
agreements incurred in the ordinary course of business; 
 (31) Liens on the Capital Stock of Unrestricted Subsidiaries; 

(32) Liens on inventory or equipment of the Company or any of its Restricted Subsidiaries granted in the ordinary course of
business to the Company’s or such Restricted Subsidiary’s clients or customers at which such inventory or equipment is located; 

(33) pledges or deposits made in the ordinary course of business to secure liability to insurance carriers and Liens on
insurance policies and the proceeds thereof (whether accrued or not), rights or claims against an insurer or other similar asset securing insurance premium financings permitted under clause (22) of the definition of “Permitted Debt”;

 (34) Liens on cash deposits of the Company and Foreign Subsidiaries subject to a Cash Pooling Arrangement or otherwise
over bank accounts of the Company and Foreign Subsidiaries maintained as part of the Cash Pooling Arrangement, in each case securing liabilities for overdrafts of the Company and Foreign Subsidiaries participating in such Cash Pooling Arrangements;

  
 -28- 

 (35) any encumbrance or retention (including put and call agreements and rights
of first refusal) with respect to the Equity Interests of any joint venture or similar arrangement pursuant to the joint venture or similar agreement with respect to such joint venture or similar arrangement; 

(36) Liens on property subject to Sale and Lease-Back Transactions permitted hereunder and general intangibles related thereto;
and 
 (37) Liens consisting of customary contractual restrictions on cash and Cash Equivalents. 

“Person” means any individual, corporation, partnership, joint venture, association, joint stock company, trust,
unincorporated organization, limited liability company or government or other entity. 
 “Preferred Stock” means any Equity
Interest with preferential rights of payment of dividends upon liquidation, dissolution or winding up. 
 “Purchase Amount”
has the meaning set forth in the definition of “Offer to Purchase.” 
 “Purchase Date” has the meaning set forth
in the definition of “Offer to Purchase.” 
 “Purchase Price” has the meaning set forth in the definition of
“Offer to Purchase.” 
 “Qualified Proceeds” means assets that are used or useful in, or Capital Stock of any
Person engaged in, a Permitted Business; provided that the fair market value of any such assets or Capital Stock shall be determined by the Board of Directors of the Company in good faith. 

“Rating Agencies” means (1) S&P and Moody’s or (2) if S&P or Moody’s or both of them are not
making ratings publicly available, a nationally recognized statistical rating organization within the meaning of Rule 15c3-1(c)(2) under the Exchange Act, as the case may be, selected by the Company,
which will be substituted for S&P or Moody’s or both, as the case may be. 
 “Receivables Facility” means any of
one or more receivables financing facilities as amended, supplemented, modified, extended, renewed, restated or refunded from time to time, the obligations of which are non-recourse (except for customary representations, warranties, covenants and
indemnities made in connection with such facilities) to the Company or any of its Restricted Subsidiaries (other than a Receivables Subsidiary) pursuant to which the Company or any of its Restricted Subsidiaries sells their accounts receivable to
either (A) a Person that is not a Restricted Subsidiary or (B) a Receivables Subsidiary that in turn sells its accounts receivable to a Person that is not a Restricted Subsidiary. 

“Receivables Fees” means distributions or payments made directly or by means of discounts with respect to any accounts
receivable or participation interest therein issued or sold in connection with, and other fees paid to a Person that is not a Restricted Subsidiary in connection with, any Receivables Facility. 

“Receivables Subsidiary” means any subsidiary formed for the purpose of, and that solely engages only in one or more
Receivables Facilities and other activities reasonably related thereto. 

  
 -29- 

 “Record Date” for the interest, if any, payable on any applicable Interest
Payment Date means April 1 or October 1 (whether or not on a Business Day) next preceding such Interest Payment Date. 

“Redemption Price,” when used with respect to any Note to be redeemed, means the price at which it is to be redeemed pursuant
to this Indenture. 
 “Refunding Capital Stock” has the meaning ascribed to such term in clause (2) of the second
paragraph of Section 4.7. 
 “Registration Rights Agreement” means the Registration Rights Agreement, dated as
of October 7, 2014, by and between VWR Corporation and Varietal Distribution Holdings, LLC. 
 “Regulation S Global
Note” means a Regulation S Temporary Global Note or Regulation S Permanent Global Note, as applicable. 
 “Regulation S
Permanent Global Note” means a permanent Global Note in the form of Exhibit A hereto bearing the Global Note Legend and the Restricted Notes Legend, issued in a denomination equal to the outstanding principal amount of the Regulation
S Temporary Global Note upon expiration of the applicable Restricted Period. 
 “Regulation S Temporary Global Note” means
a temporary Global Note in the form of Exhibit A hereto bearing the Global Note Legend, the Restricted Notes Legend and the Regulation S Temporary Global Note Legend and deposited with or on behalf of, and registered in the name of, the
Common Depositary or its nominee, issued in a denomination equal to the outstanding principal amount of the Notes initially sold in reliance on Rule 903. 

“Regulation S Temporary Global Note Legend” means the legend set forth in Exhibit A. 

“Related Business Assets” means assets (other than cash or Cash Equivalents) used or useful in a Permitted Business,
provided that any assets received by the Company or a Restricted Subsidiary in exchange for assets transferred by the Company or a Restricted Subsidiary shall not be deemed to be Related Business Assets if they consist of securities of a
Person, unless upon a receipt of the securities of such Person, such Person would become a Restricted Subsidiary. 
 “Related
Party” means (a) with respect to each of Madison Dearborn Partners, LLC and Avista Capital Partners, L.P., (i) any investment fund controlled by or under common control with such Sponsor, any officer, director or person performing
an equivalent function of the foregoing persons, or any entity controlled by any of the foregoing Persons and (ii) any spouse or lineal descendant (including by adoption and stepchildren) of the officers and directors referred to clause (a)(i);
and (b) with respect to any officer of the Company or its Subsidiaries, (i) any spouse or lineal descendant (including by adoption and stepchildren) of the officer and (ii) any trust, corporation or partnership or other entity, in
each case to the extent not an operating company, of which an 80% or more controlling interest is held by the beneficiaries, stockholders, partners or owners who are the officer, any of the persons described in clause (i) above or any
combination of these identified relationships. 
 “Resale Restriction Termination Date” means for any Transfer Restricted
Note (or beneficial interest therein), that is (a) not a Regulation S Global Note (or Certificated Note issued in respect thereof pursuant to Section 2.6(b)), two years) from the Issue Date or, if any Additional Notes that are
Transfer Restricted Notes have been issued before the Resale Restriction Termination Date for any Transfer Restricted Notes, from the latest such original issue date of such Additional Notes, and (b) a Regulation S Global Note (or
Certificated Note issued in respect thereof pursuant to Section 2.6(b)), the date on or after 

  
 -30- 

 
the 40th consecutive day beginning on and including the later of (i) the day on which any Notes represented thereby are offered to persons other than distributors (as defined in
Regulation S) pursuant to Regulation S and (ii) the issue date for such Notes. 
 “Responsible Officer”
means, when used with respect to the Trustee, any officer assigned to the Corporate Trust Office of the Trustee having direct responsibility for the administration of this Indenture. 

“Restricted Investment” means an Investment other than a Permitted Investment. 

“Restricted Notes Legend” means the legend identified as such in Exhibit A hereto. 

“Restricted Payment” has the meaning ascribed thereto in Section 4.7. 

“Restricted Period” means, in respect of any Note issued pursuant to Regulation S, the 40-day distribution compliance period
as defined in Regulation S applicable to such Note. 
 “Restricted Subsidiary” means, at any time, any direct or indirect
Subsidiary of the Company (including any Foreign Subsidiary) that is not then an Unrestricted Subsidiary; provided, however, that upon the occurrence of an Unrestricted Subsidiary ceasing to be an Unrestricted Subsidiary, such
Subsidiary shall be included in the definition of Restricted Subsidiary. 
 “Retired Capital Stock” has the meaning
ascribed to such term in clause (2) of the second paragraph of Section 4.7. 
 “S&P” means Standard
and Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc., and any successor to its rating business. 
 “Sale
and Lease-Back Transaction” means any arrangement with any Person providing for the leasing by the Company or any Restricted Subsidiary of any real or tangible personal property, which property has been or is to be sold or transferred by
the Company or such Restricted Subsidiary to such Person in contemplation of such leasing. 
 “Secured Indebtedness” means
any Indebtedness secured by a Lien permitted to be incurred by this Indenture. 
 “Secured Indebtedness Leverage Ratio”
means, with respect to any Person, at any date the ratio of (i) Secured Indebtedness of such Person and its Restricted Subsidiaries as of such date of calculation (determined on a consolidated basis in accordance with GAAP) to (ii) EBITDA
of such Person for the four full fiscal quarters for which internal financial statements are available immediately preceding such date on which such additional Indebtedness is incurred. In the event that the Company or any of its Restricted
Subsidiaries incurs or redeems any Indebtedness subsequent to the commencement of the period for which the Secured Indebtedness Leverage Ratio is being calculated but prior to the event for which the calculation of the Secured Indebtedness Leverage
Ratio is made (the “Secured Leverage Calculation Date”), then the Secured Indebtedness Leverage Ratio shall be calculated giving pro forma effect to such incurrence or redemption of Indebtedness as if the same had
occurred at the beginning of the applicable four-quarter period. The Secured Indebtedness Leverage Ratio shall be calculated in a manner consistent with the definition of “Fixed Charge Coverage Ratio,” including any pro forma
calculations to EBITDA (including for acquisitions). 
 “Secured Leverage Calculation Date” has the meaning set forth in
the definition of “Secured Indebtedness Leverage Ratio.” 

  
 -31- 

 “Securities Act” means the Securities Act of 1933, as amended, and the rules and
regulations of the Commission promulgated thereunder. 
 “Significant Subsidiary” means any Restricted Subsidiary that
would be “significant subsidiary” as defined in Article 1, Rule 1-02 of Regulation S-X, promulgated pursuant to the Securities Act, as such Regulation is in effect on the date hereof. 

“Sponsor” means Madison Dearborn Partners, LLC, Avista Capital Partners, L.P. and their respective Affiliates (other than any
portfolio company thereof). 
 “Stated Maturity” means, with respect to any installment of interest or principal on any
series of Indebtedness, the date on which the payment of interest or principal was scheduled to be paid in the original documentation governing such Indebtedness, and will not include any contingent obligations to repay, redeem or repurchase any
such interest or principal prior to the date originally scheduled for the payment thereof. 
 “Subordinated Indebtedness”
means (a) with respect to the Company, any Indebtedness of the Company that is by its terms subordinated in right of payment to the Notes and (b) with respect to any Guarantor of the Notes, any Indebtedness of such Guarantor that is by its
terms subordinated in right of payment to its Guarantee of the Notes. 
 “Subsidiary” means, with respect to any specified
Person: 
 (a) any corporation, association or other business entity, of which more than 50% of the total voting power of
shares of Capital Stock entitled (without regard to the occurrence of any contingency) to vote in the election of directors, managers or trustees thereof is at the time owned or controlled, directly or indirectly, by that Person or one or more of
the other Subsidiaries of that Person (or a combination thereof); and 
 (b) any partnership, joint venture, limited
liability company or similar entity of which (x) more than 50% of the capital accounts, distribution rights, total equity and voting interests or general or limited partnership interests, as applicable, are owned or controlled, directly or
indirectly, by such Person or one or more of the other Subsidiaries of that Person or a combination thereof whether in the form of membership, general, special or limited partnership or otherwise and (y) such Person or any Wholly Owned
Restricted Subsidiary of such Person is a controlling general partner or otherwise controls such entity. 
 “Temporary Regulation S
Notes Legend” means the legend identified as such in Exhibit A hereto. 
 “TIA” means the Trust
Indenture Act of 1939 (15 U.S. Code §§ 77aaa-77bbbb), as amended, as in effect on the date hereof. 
 “Total
Assets” means total assets of the Company and its Restricted Subsidiaries on a consolidated basis prepared in accordance with GAAP, shown on the most recent balance sheet of the Company and its Restricted Subsidiaries as may be expressly
stated. 
 “Total Net Tangible Assets” means total assets of the Company and its Restricted Subsidiaries, less all
goodwill, trade names, trademarks, patents and any other like intangibles, all on a consolidated basis prepared in accordance with GAAP, shown on the most recent balance sheet of the Company and its Restricted Subsidiaries as may be expressly
stated. 

  
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 “Transaction Expenses” means any fees or expenses incurred or paid by the
Company or any Restricted Subsidiary in connection with the Transactions. 
 “Transactions” means the issuance of the Notes
and the provision of Guarantees by the Guarantors and the related transactions described under “Use of Proceeds” in the Offering Circular. 

“Transfer Restricted Notes” means Notes that bear or are required to bear the Restricted Notes Legend. 

“Trustee” has the meaning set forth in the preamble to this Indenture. 

“Unrestricted Subsidiary” means (i) any Subsidiary of the Company that at the time of determination is an Unrestricted
Subsidiary (as designated by the Board of Directors of the Company, as provided below) and (ii) any Subsidiary of an Unrestricted Subsidiary. The Board of Directors of the Company may designate any Subsidiary of the Company (including any
existing Subsidiary and any newly acquired or newly formed Subsidiary) to be an Unrestricted Subsidiary unless such Subsidiary or any of its Subsidiaries owns any Equity Interests or Indebtedness of, or owns or holds any Lien on, any property of,
the Company or any Subsidiary of the Company (other than any Unrestricted Subsidiary of the Subsidiary to be so designated); provided that (a) any Unrestricted Subsidiary must be an entity of which shares of the Capital Stock or other
equity interests (including partnership interests) entitled to cast at least a majority of the votes that may be cast by all shares or equity interests having ordinary voting power for the election of directors or other governing body are owned,
directly or indirectly, by the Company, (b) such designation complies with Section 4.7 and (c) each of (I) the Subsidiary to be so designated and (II) its Subsidiaries has not at the time of designation, and does not
thereafter, create, incur, issue, assume, guarantee or otherwise become directly or indirectly liable with respect to any Indebtedness pursuant to which the lender has recourse to any of the assets of the Company or any Restricted Subsidiary (other
than the Capital Stock of such Subsidiary to be so designated). The Board of Directors of the Company may designate any Unrestricted Subsidiary to be a Restricted Subsidiary; provided that, immediately after giving effect to such designation,
no Event of Default shall have occurred and be continuing and any Indebtedness assumed or otherwise incurred in connection with such designation shall have been permitted to have been incurred by the Company pursuant to Section 4.9. Any
such designation by the Board of Directors of the Company shall be notified by the Company to the Trustee by promptly filing with such Trustee a copy of the Board Resolution giving effect to such designation and an Officers’ Certificate
certifying that such designation complied with the foregoing provisions. 
 “U.S. Dollar Equivalent” means with respect to
any monetary amount in a currency other than U.S. dollars, at any time for determination thereof, the amount of U.S. dollars obtained by converting such foreign currency involved in such computation into U.S. dollars at the spot rate for the
purchase of U.S. dollars with the applicable foreign currency as published in The Wall Street Journal in the “Exchange Rates” column under the heading “Currency Trading” on the date two (2) Business Days prior to such
determination. 
 Except as described in Section 4.9, whenever it is necessary to determine whether the Company has complied
with any covenant in this Indenture or a Default has occurred and an amount is expressed in a currency other than U.S. dollars, such amount will be treated as the U.S. Dollar Equivalent determined as of the date such amount is initially
determined in such currency. 
 “Voting Stock” of any Person as of any date means the Capital Stock of such Person that is
at the time entitled to vote in the election of the Board of Directors of such Person. 

  
 -33- 

 “Weighted Average Life to Maturity” means, when applied to any Indebtedness at
any date, the number of years obtained by dividing: 
 (1) the sum of the products obtained by multiplying (a) the
amount of each then remaining installment, sinking fund, serial maturity or other required payments of principal, including payment at final maturity, in respect of the Indebtedness, by (b) the number of years (calculated to the nearest
one-twelfth) that will elapse between such date and the making of such payment; by 
 (2) the then outstanding principal
amount of such Indebtedness. 
 “Wholly Owned Restricted Subsidiary” is any Wholly Owned Subsidiary that is a Restricted
Subsidiary. 
 “Wholly Owned Subsidiary” of any Person means a Subsidiary of such Person, 100% of the outstanding Capital
Stock or other ownership interests of which (other than directors’ qualifying shares and shares issued to foreign nationals under applicable law) shall at the time be owned by such Person or by one or more Wholly Owned Subsidiaries of such
Person or by such Person and one or more Wholly Owned Subsidiaries of such Person. 
 SECTION 1.2 Other Definitions. 

 

			
	Term	  	Defined in
Section
		
	 “Acceleration Notice”
	  	6.2
	 “Act”
	  	12.14(a)
	 “Affiliate Transaction”
	  	4.11
	 “Agent Members”
	  	2.6(a)
	 “Change of Control Payment”
	  	4.14
	 “Change of Control Payment Date”
	  	4.14
	 “Covenant Defeasance”
	  	8.3
	 “Event of Default”
	  	6.1
	 “Excess Proceeds”
	  	4.10
	 “incur”
	  	4.9
	 “Interest Payment Date”
	  	Exhibit A
	 “Legal Defeasance”
	  	8.2
	 “Limited Non-Guarantor Debt Exceptions”
	  	4.9
	 “Offer Amount”
	  	3.9
	 “QIBs”
	  	2.1(b)
	 “QIB Global Note”
	  	2.1(b)
	 “Refinancing Indebtedness”
	  	4.9
	 “Registrar”
	  	2.3
	 “Regulation S”
	  	2.1(b)
	 “Rule 144A”
	  	2.1(b)
	 “Successor Company”
	  	5.1
	 “Successor Guarantor”
	  	11.5(a)
	 “Terminated Covenants”
	  	4.20

  
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 SECTION 1.3 [Reserved]. 

SECTION 1.4 Rules of Construction. 

Unless the context otherwise requires: 

(1) a term has the meaning assigned to it herein; 

(2) an accounting term not otherwise defined herein has the meaning assigned to it in accordance with GAAP; 

(3) “or” is not exclusive; 

(4) words in the singular include the plural, and in the plural include the singular; 

(5) “will” shall be interpreted to express a command; 

(6) unless otherwise specified, any reference to Section or Article refers to such Section or Article of this Indenture; 

(7) provisions apply to successive events and transactions; and 

(8) references to sections of or rules under the Securities Act or the Exchange Act shall be deemed to include substitute,
replacement or successor sections or rules adopted by the Commission from time to time. 
 ARTICLE II 

THE NOTES 
 SECTION 2.1 Form
and Dating. 
 The Notes and the Trustee’s certificate of authentication shall be substantially in the form of Exhibit A
attached hereto. The Notes may have notations, legends or endorsements required by law, stock exchange rule or usage; provided, that the text of any such notations, legends or endorsements shall be delivered to the Trustee in writing by the Company.
Each Note shall be dated the date of its authentication. The Notes initially shall be issued only in minimum denominations of €100,000 and integral multiples of €1,000 in excess thereof. The terms and provisions contained in the Notes
shall constitute, and are hereby expressly made, a part of this Indenture and each party hereto, by their execution and delivery of this Indenture, expressly agree to such terms and provisions and to be bound thereby. However, to the extent any
provision of any Note conflicts with the express provisions of this Indenture, the provisions of this Indenture shall govern and be controlling. 

(a) The Notes shall be issued initially in the form of one or more Global Notes substantially in the form attached as Exhibit A
hereto, which shall be deposited on behalf of the purchasers of the Notes represented thereby with the Common Depositary, and registered in the name of the Common Depositary or a nominee of the Common Depositary, duly executed by the Company and
authenticated by the Trustee as hereinafter provided. 
 Each Global Note shall represent such of the outstanding Notes as shall be
specified therein and each shall provide that it shall represent the aggregate principal amount of outstanding Notes from time to 

  
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time endorsed thereon and that the principal aggregate amount of outstanding Notes represented thereby may from time to time be reduced or increased, as appropriate, to reflect exchanges,
redemptions and transfers of interests. Any endorsement of a Global Note to reflect the amount of any increase or decrease in the aggregate principal amount of outstanding Notes represented thereby shall be made by the Registrar in accordance with
instructions given by the Holder thereof as required by Section 2.6 hereof. The aggregate amount outstanding of any Global Note shall be reflected on the books and records of the Trustee. 

Except as set forth in Section 2.6 hereof, the Global Notes may be transferred, in whole and not in part, only to another nominee
of the Common Depositary or to a successor of the Common Depositary or its nominee. 
 (b) The Initial Notes are being issued by the Company
only (i) to “qualified institutional buyers” (as defined in Rule 144A under the Securities Act (“Rule 144A”)) (“QIBs”) and (ii) in reliance on Regulation S under the Securities Act
(“Regulation S”). After such initial offers, Initial Notes that are Transfer Restricted Notes may be transferred to QIBs, in reliance on Rule 144A or outside the United States pursuant to Regulation S or to the
Company, in accordance with certain transfer restrictions. Initial Notes that are offered in reliance on Rule 144A shall be issued in the form of one or more permanent Global Notes substantially in the form set forth in Exhibit A
(the “QIB Global Note”) deposited with the Common Depositary, duly executed by the Company and authenticated by the Trustee as hereinafter provided. 

Notes offered and sold in reliance on Regulation S shall be issued initially in the form of the Regulation S Temporary Global Note, duly
executed by the Company and authenticated by the Trustee as hereinafter provided. Following (i) the termination of the applicable Restricted Period, (ii) receipt by the Company of any certificate or other evidence in a form reasonably
acceptable to it as required pursuant to Rule 903(b)(3)(ii)(B) of Regulation S and (iii) the receipt by the Trustee of an Officers’ Certificate from the Company, certifying that the Trustee shall remove the Regulation S Temporary Global
Note Legend from the Regulation S Temporary Global Note, following which temporary beneficial interests in the Regulation S Temporary Global Note shall automatically become beneficial interests in the Regulation S Permanent Global Note pursuant to
the Applicable Procedures. 
 The Regulation S Global Note shall be in the form set forth in Exhibit A and deposited with the
Common Depositary, duly executed by the Company and authenticated by the Trustee as hereinafter provided. The QIB Global Note and the Regulation S Global Note shall each be issued with separate Common Code/ISIN numbers. The aggregate principal
amount of each Global Note may from time to time be increased or decreased by adjustments made on the records of the Trustee, as Note Custodian. Transfers of Notes between QIBs and to or by purchasers pursuant to Regulation S shall be
represented by appropriate increases and decreases to the respective amounts of the appropriate Global Notes, as more fully provided in Section 2.16. 

(c) Section 2.1(b) shall apply only to Global Notes deposited with or on behalf of the Common Depositary. 

The Company shall execute and the Trustee shall, in accordance with Section 2.1(b) and this Section 2.1(c),
authenticate and deliver the Global Notes that (i) shall be registered in the name of the Common Depositary or the nominee of the Common Depositary and (ii) shall be delivered by the Trustee to the Common Depositary or pursuant to the
Common Depositary’s instructions. 
 Participants shall have no rights either under this Indenture with respect to any Global Note held
on their behalf by the Common Depositary or under such Global Note, and the Common Depositary will be treated by the Company, the Trustee and any agent of the Company or the Trustee as the absolute 

  
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owner of such Global Note for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company, the Trustee or any Agent or other agent of the Company or the
Trustee from giving effect to any written certification, proxy or other authorization furnished by the Common Depositary or impair, as between the Common Depositary and its Participants, the operation of customary practices of such Common Depositary
governing the exercise of the rights of an owner of a beneficial interest in any Global Note. 
 The Trustee shall have no responsibility or
obligation to any Beneficial Owner that is a member of (or a participant in) any Clearing System or any other Person with respect to the accuracy of the records of such Clearing System (or its nominee) or of any participant or member thereof, with
respect to any ownership interest in the Notes or with respect to the delivery of any notice (including any notice of redemption) or the payment of any amount or delivery of any Notes (or other security or property) under or with respect to the
Notes. The Trustee may rely (and shall be fully protected in relying) upon information furnished by such Clearing System with respect to its members, participants and any beneficial owners in the Notes. 

(d) Notes issued in certificated form shall be substantially in the form of Exhibit A attached hereto. 

(e) The Paying Agent (in lieu of the Trustee) shall be responsible for: (i) paying sums due on the Notes; and (ii) as long as the
Notes are in global form, arranging on behalf of and at the expense of the Company for notices to be communicated to Holders in accordance with the terms of this Indenture. Each reference in this Indenture to the performance of duties set forth in
clauses (i) and (ii) above by the Trustee includes performance of such duties by the Paying Agent. 
 SECTION 2.2 Execution and
Authentication. 
 An Officer shall sign the Notes for the Company by manual or facsimile signature. 

If an Officer whose signature is on a Note no longer holds that office at the time a Note is authenticated, the Note shall nevertheless be
valid. 
 A Note shall not be valid until authenticated by the manual signature of a Responsible Officer of the Trustee. The signature shall
be conclusive evidence that the Note has been authenticated under this Indenture. 
 The Trustee shall, upon a written order of the Company
signed by one Officer directing the Trustee to authenticate the Notes and certifying that all conditions precedent to the issuance of the Notes contained herein have been complied with and receipt of an Opinion of Counsel, authenticate Notes for
original issue up to the aggregate principal amount stated in paragraph 4 of the Notes. The aggregate principal amount of Notes outstanding at any time may not exceed the aggregate principal amount in paragraph 4 of the Notes except as
provided in Section 2.8 hereof. 
 The Company may appoint an authenticating agent reasonably acceptable to the Trustee to
authenticate Notes. Unless limited by the terms of such appointment, an authenticating agent may authenticate Notes whenever the Trustee may do so. Each reference in this Indenture to authentication by the Trustee includes authentication by such
agent. An authenticating agent has the same rights as an Agent to deal with Holders or the Company or an Affiliate of the Company. 

  
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 SECTION 2.3 Registrar; Transfer Agent and Paying Agent. 

The Company shall maintain (i) an office or agency where Notes may be presented for registration of transfer or for exchange
(“Registrar”), (ii) an office or agency where Notes may be transferred or exchanged (the “Transfer Agent”) and (iii) an office or agency where Notes may be presented for payment to a Paying Agent. The
Registrar shall keep a register of the Notes and of their transfer and exchange. The Registrar and the Transfer Agent will maintain a register reflecting ownership of definitive registered notes outstanding from time to time and will make payments
on and facilitate transfers of definitive registered Notes on behalf of the Company. The Company may appoint one or more co-registrars, one or more transfer agents and one or more additional paying agents. The term “Registrar” includes any
co-registrar, the term “Transfer Agent” includes any additional transfer agent and the term “Paying Agent” includes any additional paying agent. The Company may change any Paying Agent or Registrar without notice to any Holder.
So long as the Notes are listed on the Official List of the Irish Stock Exchange and the rules of such exchange so require, the Company will publish a notice of any change of Paying Agent, Registrar or Transfer Agent in a newspaper having a general
circulation in Ireland (which is expected to be The Irish Times) or, to the extent and in the manner permitted by such rules, posted on the website of the Irish Stock Exchange at http://www.ise.ie or otherwise in accordance with the
requirements of the rules of the Irish Stock Exchange. 
 The Company shall promptly notify the Trustee in writing, and the Trustee shall
notify the Holders, of the name and address of any Agent not a party to this Indenture. The Company shall enter into an appropriate agency agreement with any Agent not a party to this Indenture. The agreement shall implement the provisions of this
Indenture that relate to such Agent. If the Company fails to appoint or maintain a Registrar or Paying Agent, or fails to give the foregoing notice, the Trustee shall act as such, and shall be entitled to appropriate compensation in accordance with
Section 7.7 hereof. The Company or any of its Restricted Subsidiaries may act as Paying Agent, Transfer Agent or Registrar; provided, however, that in no event may the Company appoint a Paying Agent in any member state of the European
Union where the Paying Agent would be obliged to withhold or deduct tax in connection with any payment made by it in relation to the Notes unless the Paying Agent would be so obliged if it were located in all other member states. 

The Company shall maintain a Paying Agent in a European Union member state that will not be obligated to withhold or deduct tax pursuant to
the European Union Directive 2003/48/EC, as amended or supplemented from time to time, including European Council Directive 2014/48/EU, or any other directive implementing the conclusions of the ECOFIN meeting of 26 and 27 November 2000
regarding the taxation of savings income (the “Savings Directive”), or any law implementing or complying with or introduced in order to conform to, such Savings Directive. 

The Company initially appoints Deutsche Bank AG, London Branch to act as the Paying Agent with respect to the Global Notes. The Company
initially appoints Deutsche Bank Luxembourg S.A. to act as the Registrar and Transfer Agent with respect to the Global Notes. 
 SECTION 2.4
Paying Agent to Hold Money in Trust. 
 The Company shall require each Paying Agent not a party to this Indenture to agree in writing
that such Paying Agent shall hold in trust for the benefit of the Holders or the Trustee all money held by the Paying Agent for the payment of principal, premium, if any, or interest on the Notes, and shall notify the Trustee of any default by the
Company in making any such payment. While any such default continues, the Trustee may require a Paying Agent not a party to this Indenture to pay all money held by it to the Trustee. The Company at any time may require a Paying Agent not a party to
this Indenture to pay all 

  
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money held by it to the Trustee. Upon payment over to the Trustee, the Paying Agent (if other than the Company or a Restricted Subsidiary) shall have no further liability for the money. If the
Company or a Restricted Subsidiary acts as Paying Agent, it shall segregate and hold in a separate trust fund for the benefit of the Holders all money held by it as Paying Agent. Upon the occurrence of events specified in Section 6.1(7)
hereof, the Trustee shall serve as Paying Agent for the Notes. 
 SECTION 2.5 Holder Lists. 

The Registrar shall preserve in as current a form as is reasonably practicable the most recent list available to it of the names and addresses
of all Holders. If the Paying Agent is not the Registrar, the Company shall furnish, or cause the Registrar to furnish, to the Paying Agent and the Trustee in writing at least seven (7) Business Days before each interest payment date and at
such other times as the Trustee and Paying Agent may request in writing, a list in such form and as of such date as the Trustee and Paying Agent may reasonably require of the names and addresses of the Holders, including the aggregate principal
amount of the Notes held by each Holder thereof. 
 SECTION 2.6 Book-Entry Provisions for Global Securities. 

(a) Each Global Note shall (i) be registered in the name of the Common Depositary for such Global Notes or the nominee of such Common
Depositary, (ii) be delivered to the Trustee as custodian for such Common Depositary and (iii) bear legends as required by Section 2.6(e). 

Members of, or participants in, the Common Depositary (“Agent Members”) shall have no rights under this Indenture with
respect to any Global Note held on their behalf by the Common Depositary, or the Trustee as Note Custodian, or under the Global Note, and the Common Depositary will be treated by the Company, the Trustee Note Custodian and any agent of the Company
or the Trustee as the absolute owner of such Global Note for all purposes whatsoever. Notwithstanding the foregoing, nothing herein shall prevent the Company, the Trustee Note Custodian or any agent of the Company or the Trustee, from giving effect
to any written certification, proxy or other authorization furnished by the Common Depositary or impair, as between the Common Depositary and its Agent Members, the operation of customary practices governing the exercise of the rights of a Holder of
any Note. 
 (b) Transfers of a Global Note shall be limited to transfers of such Global Note in whole, but not in part, to the Common
Depositary, its successors or their respective nominees. Interests of beneficial owners in a Global Note may be transferred in accordance with Section 2.16 and the rules and procedures of the Common Depositary. In addition, Certificated
Notes shall be transferred to all beneficial owners (or the requesting beneficial owners, in the case of clause (ii)) in exchange for their beneficial interests only if (i) the Clearing System notifies the Company that it is unwilling or
unable to continue as a Clearing System for the Global Notes or the Common Depositary ceases to be a “clearing agency” registered under the Exchange Act and a successor Clearing System is not appointed by the Company within 90 days of
such notice or (ii) an Event of Default of which a Responsible Officer of the Trustee has received actual written notice at the Corporate Trust Office of the Trustee has occurred and is continuing and the Registrar has received a request from
any beneficial owner of an interest in the Global Note (subject to the fourth paragraph of Section 2.1(c) hereof) to issue such Certificated Notes. 

(c) In connection with the transfer of the entire Global Note to beneficial owners pursuant to clause (b) of this
Section 2.6, such Global Note shall be deemed to be surrendered to the Trustee for cancellation, and the Company shall execute, and the Trustee shall authenticate and deliver, to each beneficial owner identified by the Common Depositary
in exchange for its beneficial interest in such Global Note an equal aggregate principal amount of Certificated Notes of authorized denominations. 

  
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 (d) The registered holder of a Global Note may grant proxies and otherwise authorize any person,
including Agent Members and persons that may hold interest through Agent Members, to take any action which a Holder is entitled to take under this Indenture or the Notes. 

(e) (i) Each Global Note shall bear the Global Note Legend on the face thereof and (ii) Notes offered and sold in reliance on Regulation
S shall be issued initially in the form of one or more temporary Global Notes bearing the Temporary Regulation S Notes Legend. 
 (f)
At such time as all beneficial interests in Global Notes have been exchanged for Certificated Notes, redeemed, repurchased or cancelled, all Global Notes shall be returned to or retained and cancelled by the Trustee in accordance with
Section 2.11 hereof. At any time prior to such cancellation, if any beneficial interest in a Global Note is exchanged for Certificated Notes, redeemed, repurchased or cancelled, the principal amount of Notes represented by such Global
Note shall be reduced accordingly and an endorsement shall be made on such Global Note, by the Trustee or the Note Custodian, at the direction of the Trustee, to reflect such reduction. 

(g) General Provisions Relating to Transfers and Exchanges. 

(1) To permit registrations of transfers and exchanges, the Company shall execute and the Trustee shall authenticate Global Notes and
Certificated Notes upon receipt of a written order by the Company signed by one Officer of the Company in accordance with Section 2.2 (although Regulation S Temporary Global Notes at the Company’s election pursuant to this clause
may not be exchanged for Certificated Notes prior to (1) the expiration of the applicable Restricted Period and (2) the receipt by the Company of any certificate or other evidence in a form reasonably acceptable to it as required pursuant
to Rule 903(b)(3)(ii)(B) of Regulation S). 
 (2) No service charge shall be made to a Holder for any registration of transfer or exchange,
but the Company may require payment of a sum sufficient to cover any stamp or transfer tax or similar governmental charge payable in connection therewith (other than any such stamp or transfer taxes or similar governmental charge payable upon
exchange or transfer pursuant to Sections 2.2, 2.10, 3.7, 4.10, 4.14 and 9.5 hereto). 
 (3)
All Global Notes and Certificated Notes issued upon any registration of transfer or exchange of Global Notes or Certificated Notes shall be the valid obligations of the Company, evidencing the same debt, and entitled to the same benefits under this
Indenture, as the Global Notes or Certificated Notes surrendered upon such registration of transfer or exchange. 
 (4) The Registrar shall
not be required (A) to issue, to register the transfer of or to exchange Notes during a period beginning at the opening of 15 days before the day of any selection of Notes for redemption under Section 3.2 hereof and ending at
the close of business on the day of selection, (B) to register the transfer of or to exchange any Note so selected for redemption in whole or in part, except the unredeemed portion of any Note being redeemed in part, or (C) to register the
transfer of or to exchange a Note between a record date and the next succeeding interest payment date. 
 (5) Prior to due presentment for
the registration of a transfer of any Note, the Trustee, any Agent and the Company may deem and treat the Person in whose name any Note is registered as the absolute owner of such Note for the purpose of receiving payment of principal of, premium,
if any, and interest on such Notes and for all other purposes, and none of the Trustee, any Agent or the Company shall be affected by notice to the contrary. 

  
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 (6) The Trustee shall authenticate Global Notes and Certificated Notes in accordance with the
provisions of Section 2.2 hereof. Except as provided in Section 2.6(b), neither the Trustee nor the Registrar shall authenticate or deliver any Certificated Note in exchange for a Global Note. 

(7) Each Holder agrees to provide reasonable indemnity to the Company and the Trustee against any liability that may result from the transfer,
exchange or assignment of such Holder’s Note in violation of any provision of this Indenture and/or applicable United States federal or state securities law. 

(8) Neither the Trustee nor any Agent have any obligation or duty to monitor, determine or inquire as to compliance with any restrictions on
transfer imposed under this Indenture or under applicable law with respect to any transfer of any interest in any Note (including any transfers between or among Agent Members or beneficial owners of interests in any Global Note) other than to
require delivery of such certificates and other documentation or evidence as are expressly required by, and to do so if and when expressly required by the terms of, this Indenture, and to examine the same to determine substantial compliance as to
form with the express requirements hereof. 
 (h) The Trustee and the Agents shall have no responsibility for any actions taken or not taken
by Euroclear or Clearstream, as the case may be. 
 SECTION 2.7 Replacement Notes. 

If any mutilated Note is surrendered to the Trustee, or the Company and the Trustee receive evidence to their satisfaction of the destruction,
loss or theft of any Note, the Company shall issue and the Trustee, upon the written order of the Company signed by one Officer of the Company, shall authenticate a replacement Note if the Trustee’s requirements are met. In connection with the
replacement of a Note, the Company and the Trustee will require an indemnity bond from the Holder that is sufficient in the judgment of the Trustee and the Company to protect the Company, the Trustee, any Agent and any authenticating agent from any
loss that any of them may suffer if a Note is replaced. The Company and the Trustee may charge for their expenses in replacing a Note. 

Every replacement Note is an additional obligation of the Company and shall be entitled to all of the benefits of this Indenture equally and
proportionately with all other Notes duly issued hereunder. 
 SECTION 2.8 Outstanding Notes. 

The Notes outstanding at any time are all the Notes authenticated by the Trustee except for those cancelled by it, those delivered to it for
cancellation, those reductions in the interest in a Global Note effected by the Trustee in accordance with the provisions hereof, and those described in this Section 2.8 as not outstanding. Except as set forth in Section 2.9
hereof, a Note does not cease to be outstanding because the Company or an Affiliate of the Company holds the Note. 
 If a Note is replaced
pursuant to Section 2.7 hereof, it ceases to be outstanding unless the Trustee receives proof satisfactory to it that the replaced Note is held by a bona fide purchaser. 

If the principal amount of any Note is considered paid under Section 4.1 hereof, it ceases to be outstanding and interest on it
ceases to accrue. 
 If the Paying Agent (other than the Company, a Restricted Subsidiary or an Affiliate of any thereof) holds, on a
redemption date or maturity date, money sufficient to pay Notes payable on that date, then on and after that date such Notes shall be deemed to be no longer outstanding and shall cease to accrue interest. 

  
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 SECTION 2.9 Treasury Notes. 

In determining whether the Holders of the required aggregate principal amount of Notes have concurred in any direction, waiver or consent,
Notes owned by the Company or by any Affiliate of the Company shall be considered as though not outstanding, except that for the purposes of determining whether the Trustee shall be protected in relying on any such direction, waiver or consent, only
Notes shown on the register or identified by the Company in an Officers’ Certificate as being owned shall be so disregarded. Notwithstanding the foregoing, Notes that are to be acquired by the Company or an Affiliate of the Company pursuant to
an exchange offer, tender offer or other agreement shall not be deemed to be owned by such entity until legal title to such Notes passes to such entity. 

SECTION 2.10 Temporary Notes. 

Until Certificated Notes are ready for delivery, the Company may prepare and the Trustee shall authenticate temporary Notes upon a written
order of the Company signed by one Officer of the Company in accordance with Section 2.2. Temporary Notes shall be substantially in the form of Certificated Notes but may have variations that the Company considers appropriate for
temporary Notes. Without unreasonable delay, the Company shall prepare and the Trustee shall upon receipt of a written order of the Company signed by one Officer authenticate Certificated Notes in exchange for temporary Notes. 

Holders of temporary Notes shall be entitled to all of the benefits of this Indenture. 

SECTION 2.11 Cancellation. 

The Company at any time may deliver to the Trustee for cancellation any Notes previously authenticated and delivered hereunder or which the
Company may have acquired in any manner whatsoever, and all Notes so delivered shall be promptly cancelled by the Trustee. All Notes surrendered for registration of transfer, exchange or payment, if surrendered to any Person other than the Trustee,
shall be delivered to the Trustee. The Trustee and no one else shall cancel all Notes surrendered for registration of transfer, exchange, payment, replacement or cancellation. Subject to Section 2.7 hereof, the Company may not issue new
Notes to replace Notes that it has redeemed or paid or that have been delivered to the Trustee for cancellation. All cancelled Notes held by the Trustee shall be disposed of in accordance with its customary practice, and certification of their
disposal delivered to the Company. 
 SECTION 2.12 Defaulted Interest. 

If the Company defaults in a payment of interest on the Notes, it shall pay the defaulted interest in any lawful manner plus, to the
extent lawful, interest payable on the defaulted interest, to the Persons who are Holders on a subsequent special record date, which date shall be at the earliest practicable date but in all events at least five (5) Business Days prior to the
payment date, in each case at the rate provided in the Notes and in Section 4.1 hereof. The Company shall fix or cause to be fixed each such special record date and payment date and shall promptly thereafter notify the Trustee of any
such date. At least 15 days before the special record date, the Company (or the Trustee, in the name and at the expense of the Company) shall mail or cause to be mailed to Holders a notice that states the special record date, the related
payment date and the amount of such interest to be paid. 

  
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 SECTION 2.13 [Reserved]. 

SECTION 2.14 Computation of Interest. 

Interest on the Notes shall be computed on the basis of a 360-day year comprised of twelve 30-day months. 

SECTION 2.15 ISIN and Common Code Numbers. 

The Company in issuing the Notes may use ISIN and/or Common Code numbers, and if it does so, the Trustee and the Agents shall use the ISIN
and/or Common Code numbers in notices of redemption or exchange as a convenience to Holders; provided that any such notice may state that no representation is made as to the correctness or accuracy of the ISIN and/or Common Code numbers
printed in the notice or on the Notes and that reliance may be placed only on the other identification numbers printed on the Notes. The Company shall promptly notify the Trustee and the Agents of any change in the ISIN and/or Common Code numbers.

 SECTION 2.16 Special Transfer Provisions. 

Each Initial Note and Additional Note issued pursuant to an exemption from registration under the Securities Act will constitute a Transfer
Restricted Note and be required to bear the Restricted Notes Legend until the expiration of the Resale Restriction Termination Date therefor, unless and until such Transfer Restricted Note is transferred or exchanged pursuant to an effective
registration statement under the Securities Act. The following provisions shall apply to the transfer of a Transfer Restricted Note: 

(a) Transfers to QIBs. The following provisions shall apply with respect to the registration of any proposed transfer of
a Transfer Restricted Note (other than pursuant to Regulation S): 
 (i) The Registrar shall register the transfer of a
Transfer Restricted Note by a Holder to a QIB if such transfer is being made by a proposed transferor who has provided the Registrar with (a) an appropriately completed certificate of transfer in the form attached to the Note and (b) a
letter substantially in the form set forth in Exhibit C hereto. 
 (ii) If the proposed transferee is an Agent
Member and the Transfer Restricted Note to be transferred consists of an interest in the Regulation S Global Note, upon receipt by the Registrar of (x) the items required by paragraph (i) above and (y) instructions given in
accordance with the Common Depositary’s and the Registrar’s procedures therefor, the Registrar shall reflect on its books and records the date and an increase in the principal amount of the QIB Global Note in an amount equal to the
principal amount of the beneficial interest in the Regulation S Global Note to be so transferred, and the Registrar shall reflect on its books and records the date and an appropriate decrease in the principal amount of such Regulation S
Global Note. 
 (b) Transfers Pursuant to Regulation S. The following provisions shall apply with respect to
registration of any proposed transfer of a Transfer Restricted Note pursuant to Regulation S: 
 (i) The Registrar shall
register any proposed transfer of a Transfer Restricted Note pursuant to Regulation S by a Holder upon receipt of (a) an appropriately completed certificate of transfer in the form attached to the Note and (b) a letter substantially
in the form set forth in Exhibit D hereto from the proposed transferor. 

  
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 (ii) If the proposed transferee is an Agent Member holding a beneficial interest
in a QIB Global Note and the Transfer Restricted Note to be transferred consists of an interest in a QIB Global Note, upon receipt by the Registrar of (x) the letter, if any, required by paragraph (i) above and (y) instructions in
accordance with the Common Depositary’s and the Registrar’s procedures therefor, the Registrar shall reflect on its books and records the date and an increase in the principal amount of the Regulation S Global Note in an amount equal
to the principal amount of the beneficial interest in the QIB Global Note to be transferred, and the Registrar shall reflect on its books and records the date and an appropriate decrease in the principal amount of the QIB Global Note. 

(c) Restricted Notes Legend. Upon the transfer, exchange or replacement of Notes not bearing the Restricted Notes
Legend, the Registrar shall deliver Notes that do not bear the Restricted Notes Legend. Upon the transfer, exchange or replacement of Notes bearing the Restricted Notes Legend, the Registrar shall deliver only Notes that bear the Restricted Notes
Legend unless there is delivered to the Registrar an Opinion of Counsel reasonably satisfactory to the Company and the Trustee to the effect that neither such legend nor the related restrictions on transfer are required in order to maintain
compliance with the provisions of the Securities Act. 
 (d) General. By its acceptance of any Note bearing the
Restricted Notes Legend, each Holder of such a Note acknowledges the restrictions on transfer of such Note set forth in this Indenture and in the Restricted Notes Legend and agrees that it shall transfer such Note only as provided in this Indenture.
A transfer of a beneficial interest in a Global Note that does not involve an exchange of such interest for a Certificated Note or a beneficial interest in another Global Note shall be subject to compliance with applicable law and the applicable
procedures of the Common Depositary, but is not subject any procedure required by this Indenture. 
 The Registrar shall retain copies of
all letters, notices and other written communications received pursuant to this Section 2.16. 
 In no event shall Certificated
Notes be issued upon the transfer or exchange of beneficial interests in a Regulation S Temporary Global Note prior to (A) the expiration of the applicable Restricted Period therefor and (B) the receipt by the Company of any certificate or
other evidence in a form reasonably acceptable to it as required pursuant to Rule 903(b)(3)(ii)(B) of Regulation S, except in the case of a transfer pursuant to an exemption from the registration requirements of the Securities Act other than
Rule 903 or Rule 904. 
 SECTION 2.17 Issuance of Additional Notes. 

The Company shall be entitled to issue Additional Notes under this Indenture that shall have identical terms as the Initial Notes, other than
with respect to the date of issuance, issue price and amount of interest payable on the first interest payment date applicable thereto (and, if such Additional Notes shall be issued in the form of Transfer Restricted Notes, other than with respect
to transfer restrictions, any registration rights agreement and additional interest with respect thereto); provided that such issuance is not prohibited by the terms of this Indenture, including Section 4.9 and
Section 4.12. 
 The Initial Notes and any Additional Notes subsequently issued under this Indenture will be treated as a single
class for all purposes under this Indenture, including waivers, amendments, redemptions and offers to purchase. Unless the context requires otherwise, references to “Notes” for all purposes of this Indenture include any Additional Notes.
Any Additional Notes shall be issued with the benefit of an indenture supplemental to this Indenture. 

  
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 With respect to any Additional Notes, the Company shall set forth in a Board Resolution and in an
Officers’ Certificate, a copy of each of which shall be delivered to the Trustee, the following information: 
 (1) the
aggregate principal amount of such Additional Notes to be authenticated and delivered pursuant to this Indenture; 
 (2) the
issue price, the issue date, the Common Code and/or ISIN number of such Additional Notes, the first interest payment date and the amount of interest payable on such first interest payment date applicable thereto and the date from which interest
shall accrue; and 
 (3) whether such Additional Notes shall be Transfer Restricted Notes. 

ARTICLE III 
 REDEMPTION AND
PREPAYMENT 
 SECTION 3.1 Notices to Trustee. 

If the Company elects to redeem Notes pursuant to the optional redemption provisions of Section 3.7 hereof, it shall furnish to
the Trustee, at least 30 days or such shorter period as is acceptable to the Trustee before a redemption date, an Officers’ Certificate setting forth (i) the Section of this Indenture pursuant to which the redemption shall occur,
(ii) the redemption date, (iii) the principal amount of Notes to be redeemed and (iv) the Redemption Price. 
 If the Company
is required to make an offer to purchase Notes pursuant to Sections 4.10 or 4.14 hereof, it shall furnish to the Trustee and the Agents, at least 30 days or such shorter period as is acceptable to the Trustee before the
scheduled purchase date, an Officers’ Certificate setting forth (i) the Section of this Indenture pursuant to which the offer to purchase shall occur, (ii) the terms of the offer, (iii) the principal amount of Notes to be
purchased, (iv) the purchase price and (v) the purchase date and further setting forth a statement to the effect that (a) the Company or one of its Subsidiaries has effected an Asset Sale and there are Excess Proceeds aggregating more
than $25.0 million or (b) a Change of Control has occurred, as applicable. 
 The Company will also provide the Trustee and the
Agents with any additional information that the Trustee or Agents reasonably request in connection with any redemption or offer. 
 SECTION
3.2 Selection of Notes to Be Redeemed. 
 If less than all of the Notes are to be redeemed at any time, the Registrar will select
Notes for redemption as follows: 
 (1) if the Notes are listed on any national securities exchange, in compliance with the
requirements of the principal national securities exchange on which such Notes are listed; or 
 (2) if the Notes are not
listed on any national securities exchange, on a pro rata basis to the extent practicable or in accordance with customary procedures of any Clearing System. 

  
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 No Notes of €100,000 or less shall be redeemed in part. Except as otherwise provided herein,
notices of redemption shall be mailed by first class mail at least 30 but not more than 60 days before the redemption date to each Holder of Notes to be redeemed at its registered address, except that redemption notices may be mailed more than 60
days prior to a redemption date if the notice is issued in connection with Sections 8.2, 8.3 or 8.8 hereof. Notices of redemption may, at the Company’s discretion, be conditioned on the satisfaction of one or more
conditions, including the consummation of any acquisition or financing transaction. 
 If any Note is to be redeemed in part only, the
notice of redemption that relates to such Note will state the portion of the principal amount thereof that is to be redeemed. A new Note in principal amount equal to the unredeemed portion of the original Note will be issued in the name of the
Holder thereof upon cancellation of the original Note (or appropriate adjustments to the amount and beneficial interests in a Global Note will be made, as appropriate). Notes called for redemption become due on the date fixed for redemption. 

On and after the redemption date, interest will cease to accrue on Notes or portions of them called for redemption. The Registrar shall make
the selection from the Notes outstanding and not previously called for redemption as long as the Company has deposited with the Paying Agent funds in satisfaction of the applicable Redemption Price pursuant to this Indenture and shall promptly
notify the Company in writing of the Notes selected for redemption. The Registrar may select for redemption portions (equal to €100,000 or any integral multiples of €1,000 thereof) of the principal of the Notes that have denominations
larger than €100,000. 
 SECTION 3.3 Notice of Redemption. 

Subject to the provisions of Section 3.9, at least 30 days but not more than 60 days before a redemption date, the
Company shall mail or cause to be mailed by first class mail, a notice of redemption to the Trustee, the Registrar and each Holder whose Notes are to be redeemed. 

The notice shall identify the Notes to be redeemed and shall state: 

(1) the redemption date; 

(2) the Redemption Price; 

(3) if any Note is being redeemed in part, the portion of the principal amount of such Notes to be redeemed and that, after the
redemption date, upon surrender of such Note, a new Note or Notes in principal amount equal to the unredeemed portion shall be issued upon cancellation of the original Note; 

(4) the name, telephone number and address of the Paying Agent; 

(5) that Notes called for redemption must be surrendered to the Paying Agent to collect the Redemption Price; 

(6) that, on the redemption date and, if applicable, upon the satisfaction of any conditions to such redemption set forth in
such notice of redemption, the redemption price will become due and payable upon each such Note or portion thereof, and that, unless the Company defaults in making such redemption payment, interest, if any, on Notes called for redemption ceases to
accrue on and after the redemption date; 

  
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 (7) the paragraph of the Notes and/or Section of this Indenture pursuant to which
the Notes called for redemption are being redeemed; and 
 (8) that no representation is made as to the correctness or
accuracy of the Common Code and/or ISIN number, if any, listed in such notice or printed on the Notes. 
 In addition, if such redemption is
subject to satisfaction of one or more conditions precedent, such notice of redemption shall describe each such condition, and if applicable, shall state that, in the Company’s discretion, the redemption date may be delayed until such time as
any or all such conditions shall be satisfied, or such redemption may not occur and such notice may be rescinded in the event that any or all such conditions shall not have been satisfied by the redemption date as stated in such notice, or by the
redemption date as so delayed. In no event shall such redemption be delayed for longer than 60 days following the date of the original redemption notice. In the event the Company delays such redemption, the Company shall notify the Trustee of the
new redemption date at least two (2) Business Days prior to such new redemption date. 
 At the Company’s request, the Trustee
shall give the notice of redemption in the Company’s name and at the Company’s expense; provided, however, that the Company shall have delivered to the Trustee, at least 45 days prior to the redemption date (or such
shorter period as is acceptable to the Trustee), an Officers’ Certificate requesting that the Trustee give such notice and setting forth the information to be stated in the notice as provided in the preceding paragraph. The notice mailed in the
manner herein provided shall be conclusively presumed to have been duly given whether or not the Holder receives such notice. In any case, failure to give such notice by mail or any defect in the notice to the Holder of any Note shall not affect the
validity of the proceeding for the redemption of any other Note. 
 For Notes which are represented by global certificates held on behalf of
Euroclear or Clearstream, notices may be given by delivery of the relevant notices to Euroclear and Clearstream, as applicable, for communication to entitled account holders in substitution of any mailing. So long as any Notes are listed on the
Irish Stock Exchange or any other securities exchange and admitted for trading on the Global Exchange Market of the Irish Stock Exchange, and to the extent required by the Irish Stock Exchange or such other securities exchange, the Company will
publish notices of redemption in a newspaper having general circulation in Ireland (which is expected to be The Irish Times) or, to the extent and in the manner permitted by such rules, posted on the official website of the Irish Stock
Exchange (www.ise.ie) or through other methods permitted by such rules. In addition, from the date of the listing particulars relating to the listing of the Notes on the Irish Stock Exchange, copies of the following documents will be
available for inspection during usual business hours at the specified office of the Listing Agent: (a) the Indenture (including the form of Notes); (b) the organizational documents of the Company and each of the Guarantors and (c) any
documents furnished to the Trustee under Section 4.3. 
 SECTION 3.4 Effect of Notice of Redemption. 

Except with respect to notices of redemption given in accordance with Section 3.7(d) hereof, once notice of redemption is mailed
in accordance with Section 3.3 hereof, Notes called for redemption become irrevocably due and payable on the redemption date at the Redemption Price plus accrued and unpaid interest, if any, to such date, subject to the
satisfaction of any conditions precedent provided in such notice. 
 SECTION 3.5 Deposit of Redemption of Purchase Price. 

On or before 10:00 a.m. (London time) on each redemption date or the date on which Notes must be accepted for purchase pursuant to
Section 4.10 or 4.14, the Company shall deposit with the Paying 

  
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Agent (other than the Company or an Affiliate of the Company) money sufficient to pay the Redemption Price of and accrued and unpaid interest, if any, on all Notes to be redeemed or purchased on
that date. The Paying Agent shall promptly return to the Company any money deposited with the Paying Agent by the Company in excess of the amounts necessary to pay the Redemption Price of (including any applicable premium), and accrued interest, if
any, on, all Notes to be redeemed or purchased. The Company shall no later than 10:00 a.m. (London time) on the Business Day prior to the day on which the Paying Agent is to receive payment, procure that the bank effecting payment for it confirms
via fax or tested SWIFT MT 100 message to the Paying Agent the payment instructions relating to such payment. 
 If Notes called for
redemption or tendered in an Asset Sale Offer or Change of Control Offer are paid or if the Company has deposited with the Paying Agent money sufficient to pay the redemption or purchase price of, and unpaid and accrued interest, if any, on, all
Notes to be redeemed or purchased, on and after the redemption or purchase date, interest, if any, shall cease to accrue on the Notes or the portions of Notes called for redemption or tendered and not withdrawn in an Asset Sale Offer or Change of
Control Offer (regardless of whether certificates for such securities are actually surrendered). If a Note is redeemed or purchased on or after an interest record date but on or prior to the related interest payment date, then any accrued and unpaid
interest, if any, shall be paid to the Person in whose name such Note was registered at the close of business on such record date. If any Note called for redemption shall not be so paid upon surrender for redemption because of the failure of the
Company to comply with the preceding paragraph, interest shall be paid on the unpaid principal from the redemption or purchase date until such principal is paid, and to the extent lawful on any interest not paid on such unpaid principal, in each
case, at the rate provided in the Notes and in Section 4.1 hereof. If any Note called for redemption or tendered in an Asset Sale Offer or Change of Control Offer shall not be so paid upon surrender for redemption because of the failure
of the Company to comply with the preceding paragraph, interest, if any, shall be paid on the unpaid principal, from the redemption date until such principal is paid, and to the extent lawful on any interest not paid on such unpaid principal. 

Any and all interest payable upon any redemption shall be payable in cash. 

SECTION 3.6 Notes Redeemed in Part. 

Upon surrender and cancellation of a Note that is redeemed in part, the Company shall issue and, upon the written request of an Officer of the
Company, the Trustee shall authenticate for the Holder at the expense of the Company a new Note equal in principal amount to the unredeemed portion of the Note surrendered and cancelled; provided that each such new Note will be in a principal
amount of €100,000 or integral multiples of €1,000 in excess thereof. 
 SECTION 3.7 Optional Redemption. 

(a) The Notes may be redeemed, in whole or in part, at any time prior to April 15, 2018, at the option of the Company upon not less than
30 nor more than 60 days’ prior notice via the Clearing System to each Holder’s registered address, at a redemption price equal to 100% of the principal amount of the Notes redeemed plus the Applicable Premium as of, and accrued and unpaid
interest, if any, to, the applicable redemption date (subject to the right of Holders on the relevant record date to receive interest due on the relevant interest payment date). 

(b) The Notes are subject to redemption, at the option of the Company, in whole or in part, at any time on or after April 15, 2018, upon
not less than 30 nor more than 60 days’ notice, at the following Redemption Prices (expressed as a percentage of the principal amount to be redeemed) set forth below, plus accrued and unpaid interest, if any, to, but not including, the
redemption date (subject to the right of Holders of record on the relevant regular record date to receive interest due on an interest payment date that is on or prior to the redemption date) if redeemed during the twelve-month period beginning on
April 15 of the years indicated below: 
  

					
	 Year
	  	Percentage	 
	 2018
	  	 	102.3125	% 
	 2019
	  	 	101.1563	% 
	 2020 and thereafter
	  	 	100.0000	% 

  
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 (c) In addition to the optional redemption of the Notes in accordance with the provisions of the
preceding paragraph, prior to April 15, 2018, the Company may on one or more occasions, with the net cash proceeds of one or more Equity Offerings, redeem up to 35% of the aggregate principal amount of the outstanding Notes at a Redemption
Price of 104.625% of the principal amount thereof, plus accrued and unpaid interest, if any, thereon to the date of redemption (provided that if the Equity Offering is an offering by Parent or any of its direct or indirect parent companies, a
portion of the net cash proceeds thereof equal to the amount required to redeem any such Notes is contributed to the equity capital of the Company); provided that at least 65% of the aggregate principal amount of Notes issued under this
Indenture (including any Additional Notes) remains outstanding immediately after the occurrence of any such redemption and that any such redemption occurs within 90 days following the closing of any such Equity Offering. 

(d) Notice of any redemption upon an Equity Offering may be given prior to the completion of the related Equity Offering. Notice of any
redemption, including, without limitation, upon an Equity Offering, may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to, completion of the related Equity Offering. 

(e) The Company shall have the option at any time and from time to time purchase Notes in the open market by tender offer, negotiated
transactions or otherwise, in accordance with applicable securities laws. 
 (f) If the Company effects an optional redemption of the Notes,
it will, for so long as the Notes are listed on the Official List of the Irish Stock Exchange and admitted for trading on the Global Exchange Market thereof and the rules of the Irish Stock Exchange so require, inform the Irish Stock Exchange of
such optional redemption and confirm the aggregate principal amount of the Notes that will remain outstanding immediately after such redemption. 

SECTION 3.8 Mandatory Redemption. 

Except as set forth under Sections 3.9, 4.10 and 4.14 hereof, the Company shall not be required to make mandatory
redemption or sinking fund payments with respect to the Notes. 
 SECTION 3.9 Offer to Purchase. 

In the event that the Company shall be required to commence an Offer to Purchase pursuant to an Asset Sale Offer or a Change of Control Offer,
the Company shall follow the procedures specified below. 
 On the Purchase Date, the Company shall purchase the aggregate principal amount
of Notes required to be purchased pursuant to Section 4.10 hereof or Section 4.14 hereof (the “Offer Amount”), or if less than the Offer Amount has been tendered, all Notes tendered in response to the Offer
to Purchase. Payment for any Notes so purchased shall be made in the same manner as interest payments are made. If the Purchase Date is on or after the interest record date and on or before the related interest payment date, any accrued and unpaid
interest, if any, shall be paid to the Person in whose name a Note is registered at 

  
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the close of business on such record date, and no additional interest, if any, shall be payable to the Holders who tender Notes pursuant to the Offer to Purchase. The Company shall notify the
Trustee at least 15 days (or such shorter period as is acceptable to the Trustee) prior to the mailing of the Offer of the Company’s obligation to make an Offer to Purchase, and the Offer shall be mailed by the Company or, at the
Company’s request, by the Trustee in the name and at the expense of the Company. The Offer shall contain all instructions and materials necessary to enable such Holders to tender Notes pursuant to the Offer to Purchase. 

On or before 10:00 a.m. (London time) on each Purchase Date, the Company shall irrevocably deposit with the Paying Agent (other than the
Company or an Affiliate of the Company) in immediately available funds the aggregate purchase price equal to the Offer Amount, together with accrued and unpaid interest, if any, thereon, to be held for payment in accordance with the terms of this
Section 3.9. On the Purchase Date, the Company shall, to the extent lawful, (i) accept for payment, on a pro rata basis to the extent necessary, the Offer Amount of Notes or portions thereof tendered pursuant to the
Offer to Purchase, or if less than the Offer Amount has been tendered, all Notes tendered, (ii) deliver or cause the Paying Agent or Common Depositary, as the case may be, to deliver to the Trustee Notes so accepted and (iii) deliver to
the Trustee an Officers’ Certificate stating that such Notes or portions thereof were accepted for payment by the Company in accordance with the terms of this Section 3.9. The Company, the Common Depositary or the Paying Agent, as
the case may be, shall promptly mail or deliver to each tendering Holder an amount equal to the purchase price of the Notes tendered by such Holder and accepted by the Company for purchase, plus any accrued and unpaid interest thereon, and the
Company shall promptly issue a new Note, and the Trustee, at the written request of the Company, shall authenticate and mail or deliver (or cause to be transferred by book entry) at the expense of the Company such new Note to such Holder, equal in
principal amount to any unpurchased portion of such Holder’s Notes surrendered, if any; provided that each new Note will be in a minimum principal amount of €100,000 or integral multiples of €1,000 in excess thereof. Any Note
not so accepted shall be promptly mailed or delivered by the Company to the Holder thereof. The Company shall publicly announce in a newspaper of general circulation or in a press release provided to a nationally recognized financial wire service
the results of the Offer to Purchase on the Purchase Date. 
 Other than as specifically provided in this Section 3.9, any
purchase pursuant to this Section 3.9 shall be made pursuant to the provisions of Sections 3.1 through 3.6 hereof. 

ARTICLE IV 
 COVENANTS 

SECTION 4.1 Payment of Notes. 

(a) The Company shall pay or cause to be paid the principal of, premium, if any, and interest on the Notes on the dates and in the manner
provided in the Notes. Principal, premium, if any, and interest, if any, shall be considered paid for all purposes hereunder on the date the Paying Agent, if other than the Company or a Subsidiary thereof, holds, as of 10:00 a.m. (London time),
money deposited by the Company in immediately available funds and designated for and sufficient to pay all such principal, premium, if any, and interest then due. 

(b) The Company shall no later than 10:00 a.m. (London time) on the Business Day prior to the day on which the Paying Agent is to receive
payment, procure that the bank effecting payment for it confirms via fax or tested SWIFT MT 100 message to the Paying Agent the payment instructions relating to such payment. 

  
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 (c) The obligation of the Paying Agent to make payments is subject to the Company’s
compliance with this Section 4.1. 
 (d) The Company will make payments of all such amounts without deduction or withholding
for, or on account of, any present or future taxes, duties, assessments or governmental charges of whatever nature, except as may be required by law. 

(e) The Company shall pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue principal at the
rate equal to 1% per annum in excess of the then applicable interest rate on the Notes to the extent lawful; it shall pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue
installments of interest (without regard to any applicable grace period), at the same rate to the extent lawful. 
 SECTION 4.2
Maintenance of Office or Agency. 
 The Company shall maintain the office or agency (which may be an office of the Trustee or an
Affiliate of the Trustee or Registrar) required under Section 2.3 where Notes may be surrendered for registration of transfer or for exchange and where notices and demands to or upon the Company in respect of the Notes and this Indenture
may be served. The Company shall give prompt written notice to the Trustee of the location, and any change in the location, of such office or agency. If at any time the Company shall fail to maintain any such required office or agency or shall fail
to furnish the Trustee with the address thereof, such presentations, surrenders, notices and demands may be made or served at the address of the Paying Agent set forth in Section 12.2. 

The Company may also from time to time designate one or more other offices or agencies where the Notes may be presented or surrendered for any
or all such purposes and may from time to time rescind such designations; provided, however, that no such designation or rescission shall in any manner relieve the company of its obligation to maintain an office or agency as required
under Section 2.3. The Company shall give prompt written notice to the Trustee of any such designation or rescission and of any change in the location of any such other office or agency. 

The Company hereby designates the Corporate Trust Office of the Trustee as one such office or agency of the Company in accordance with
Section 2.3 hereof. If the Notes are listed on the Official List of the Irish Stock Exchange and the rules of the Irish Stock Exchange so require, the Company will publish a notice of any change of paying agent, registrar or transfer
agent in a newspaper having a general circulation in Ireland (which is expected to be The Irish Times) or, to the extent and in the manner permitted by such rules, posted on the website of the Irish Stock Exchange at http://www.ise.ie or otherwise
in accordance with the requirements of the rules of the Irish Stock Exchange. 
 SECTION 4.3 Reports. 

Whether or not required by the Commission, so long as any Notes are outstanding, if not filed electronically with the Commission through the
Commission’s Electronic Data Gathering, Analysis, and Retrieval System (or any successor system), the Company will furnish to the Holders of Notes, within the time periods specified in the Commission’s rules and regulations for a filer
that is a “non-accelerated filer”: 
 (1) substantially the same quarterly and annual financial information that
would be required to be contained in a filing with the Commission on Forms 10-Q and 10-K, if the Company were required to file such forms, including a “Management’s Discussion and Analysis of Financial Condition and Results of
Operations” and, with respect to the annual information only, a report on the annual financial statements by the Company’s certified independent accountants; and 

(2) substantially the same current reports that would be required to be filed with the Commission on Form 8-K if the Company
were required to file such reports. 

  
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 To the extent any such information is not so filed or furnished, as applicable, within the time
periods specified above and such information is subsequently filed or furnished, as applicable, the Company will be deemed to have satisfied its obligations with respect thereto at such time and any Default or Event of Default with respect thereto
shall be deemed to have been cured; provided, that such cure shall not otherwise affect the rights of the Holders pursuant to Article VI if holders of at least 25% in principal amount of the then total outstanding Notes have declared
the principal, premium, if any, interest and any other monetary obligations on all the then outstanding Notes to be due and payable immediately and such declaration shall not have been rescinded or cancelled prior to such cure. In addition, the
Company has agreed that, for so long as any Notes remain outstanding, it will furnish to the Holders of the Notes and to securities analysts and prospective investors, upon their request, the information required to be delivered pursuant to Rule
144A(d) (4) under the Securities Act. 
 In addition, at any time a direct or indirect parent company of the Company is subject to the
reporting requirements of Section 13 or 15(d) of the Exchange Act or otherwise report on an annual and quarterly basis on forms provided for such annual and quarterly reporting pursuant to rules and regulations promulgated by the Commission,
the reports, information and other documents required to be filed and furnished to Holders of the Notes pursuant to this Section 4.3 may, at the option of the Company, be filed by and be those of such parent company rather than the
Company; provided that the same is accompanied by consolidating information that explains in reasonable detail any material differences between the information relating to such parent company, on the one hand, and the information relating to
the Company and its Restricted Subsidiaries on a standalone basis, on the other hand. 
 The Company will also make available copies of all
reports required by the first paragraph of this Section 4.3, if and so long as the Notes are listed on the Irish Stock Exchange and admitted for trading on the Global Exchange Market thereof, at the offices of the Listing Agent in
Ireland or, to the extent and in the manner permitted by such rules, post such reports on the website of the Company or the official website of the Irish Stock Exchange (www.ise.ie). 

The Company shall provide the Trustee with a sufficient number of copies of all reports and other documents and information and, if requested
by the Company, at its expense, the Trustee will deliver such reports to the Holders under this Section 4.3. 
 SECTION 4.4
Compliance Certificate. 
 The Company shall deliver to the Trustee, within 120 days after the end of each fiscal year beginning
with the fiscal year ended December 31, 2015, an Officers’ Certificate stating that a review of the activities of the Company and its Subsidiaries during the preceding fiscal year has been made under the supervision of the signing Officers
with a view to determining whether a Default or Event of Default shall have occurred and, if a Default or Event of Default shall have occurred, describing all such Defaults or Events of Default of which he or she may have knowledge and what action
the Company is taking or proposes to take with respect thereto. 
 The Company shall, so long as any of the Notes are outstanding, deliver
to the Trustee, forthwith upon any Officer becoming aware of any Default or Event of Default, an Officers’ Certificate specifying such Default or Event of Default (unless such Default or Event of Default has been cured prior to such time) and
what action the Company is taking or proposes to take with respect thereto. 

  
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 SECTION 4.5 Taxes. 

The Company shall pay, and shall cause each of its Subsidiaries to pay, prior to delinquency, all material taxes, charges, assessments and
governmental levies, except such as are contested in good faith and by appropriate proceedings and with respect to which appropriate reserves have been taken in accordance with GAAP or where the failure to effect such payment is not adverse in any
material respect to the Holders of the Notes. 
 SECTION 4.6 Stay, Extension and Usury Laws. 

The Company and each of the Guarantors covenant (to the extent that it may lawfully do so) that it shall not at any time insist upon, plead,
or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, that may affect the covenants or the performance of this Indenture; and the Company and
each of the Guarantors (to the extent that it may lawfully do so) hereby expressly waives all benefit or advantage of any such law, and covenants that it shall not, by resort to any such law, hinder, delay or impede the execution of any power herein
granted to the Trustee, but shall suffer and permit the execution of every such power as though no such law has been enacted. 
 SECTION 4.7
Limitation on Restricted Payments. 
 The Company will not, and will not permit any of its Restricted Subsidiaries to, directly or
indirectly: 
 (a) declare or pay any dividend or make any other distribution on account of the Company’s or any of its
Restricted Subsidiaries’ Equity Interests, including any dividend or distribution payable in connection with any merger or consolidation (other than (i) dividends or distributions by the Company payable in Equity Interests (other than
Disqualified Stock) of the Company or in options, warrants or other rights to purchase such Equity Interests (other than Disqualified Stock), (ii) dividends or distributions by a Restricted Subsidiary payable to the Company or any other
Restricted Subsidiary or (iii), in the case of any dividend or distribution payable on or in respect of any class or series of Equity Interests issued by a Restricted Subsidiary other than a Wholly Owned Subsidiary, pro rata dividends
or distributions to minority stockholders of such Restricted Subsidiary (or owners of an equivalent interest in the case of a Subsidiary that is an entity other than a corporation); provided that the Company or one of its Restricted
Subsidiaries receives at least its pro rata share of such dividend or distribution in accordance with its Equity Interests in such class or series of securities); 

(b) purchase, redeem or otherwise acquire or retire for value any Equity Interests of the Company or any direct or indirect
parent entity of the Company held by any Person (other than by a Restricted Subsidiary), including in connection with any merger or consolidation; 

(c) make any principal payment on, or redeem, repurchase, defease or otherwise acquire or retire for value, in each case prior
to any scheduled repayment, sinking fund payment or maturity, any Subordinated Indebtedness (other than (x) Indebtedness permitted under clause (8) of the definition of “Permitted Debt” or (y) the purchase, repurchase or
other acquisition or retirement of Subordinated Indebtedness purchased in anticipation of satisfying a sinking fund obligation, principal installment or final maturity, in each case due within one year of the date of purchase, repurchase,
acquisition or retirement); or 
 (d) make any Restricted Investment; 

  
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 (all such payments and other actions set forth in these clauses (a) through (d) being collectively
referred to as “Restricted Payments”), unless, at the time of and after giving effect to such Restricted Payment: 

(1) no Default or Event of Default has occurred and is continuing or would occur as a consequence of such Restricted Payment;

 (2) the Company would, at the time of such Restricted Payment and after giving pro forma effect thereto as if such
Restricted Payment had been made at the beginning of the applicable four-quarter period, have been permitted to incur at least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test set forth in the first paragraph of
Section 4.9; and 
 (3) such Restricted Payment, together with the aggregate amount of all other Restricted
Payments made by the Company and its Restricted Subsidiaries after the Issue Date (excluding Restricted Payments permitted by clauses (2), (3), (4), (5), (6), (7), (9), (10), (11), (13), (14), (15), (16), (17) and (18) of the next
succeeding paragraph; provided that the calculation of Restricted Payments shall also exclude the amounts paid or distributed pursuant to clause (1) of the next paragraph to the extent that the declaration of such dividend or other
distribution shall have previously been included as a Restricted Payment), is less than the sum, without duplication, of: 

(a) 50% of the Consolidated Net Income of the Company for the period (taken as one accounting period) beginning on the first
day of the fiscal quarter in which the Issue Date occurs to the end of the Company’s most recently ended fiscal quarter for which internal financial statements are available at the time of such Restricted Payment (or, in the case such
Consolidated Net Income for such period is a deficit, minus 100% of such deficit), plus 
 (b) 100% of the aggregate
net cash proceeds and the fair market value, as determined in good faith by the Board of Directors of the Company, of property and marketable securities received by the Company after the Issue Date from the issue or sale of (x) Equity Interests
of the Company (including Retired Capital Stock (as defined below) but excluding (i) cash proceeds received from the sale of Equity Interests of the Company and, to the extent actually contributed to the Company, Equity Interests of any direct
or indirect parent company of the Company to members of management, directors or consultants of the Company, any direct or indirect parent company of the Company and the Subsidiaries of the Company after the Issue Date, in each case to the extent
such amounts have been applied to Restricted Payments made in accordance with clause (4) of the next succeeding paragraph, (ii) cash proceeds received from the sale of Refunding Capital Stock (as defined below) to the extent such amounts
have been applied to Restricted Payments made in accordance with clause (2) of the next succeeding paragraph, (iii) Designated Preferred Stock, (iv) the Cash Contribution Amount and (v) Disqualified Stock) or (y) debt
securities or Disqualified Stock of the Company that have been converted into or exchanged for Equity Interests of the Company (other than Refunding Capital Stock or Equity Interests or convertible debt securities of Parent or any other direct or
indirect parent company sold to a Restricted Subsidiary or Parent and other than Disqualified Stock or Designated Preferred Stock or debt securities that have been converted into Disqualified Stock or Designated Preferred Stock), plus 

  
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 (c) 100% of the aggregate amount of cash and the fair market value, as determined
in good faith by the Board of Directors of the Company, of property and marketable securities contributed to the capital of the Company after the Issue Date (other than (i) by a Restricted Subsidiary, (ii) any Excluded Contributions,
(iii) any Disqualified Stock, (iv) any Refunding Capital Stock, (v) any Designated Preferred Stock, (vi) the Cash Contribution Amount and (vii) cash proceeds applied to Restricted Payments made in accordance with clause
(4) of the next succeeding paragraph), plus 
 (d) to the extent not already included in Consolidated Net Income,
100% of the aggregate amount received in cash and the fair market value, as determined in good faith by the Board of Directors of the Company, of property and marketable securities received after the Issue Date by means of (A) the sale or other
disposition (other than to the Company or a Restricted Subsidiary) of, or interest, return, profits, distribution, income or similar amounts in respect of, Restricted Investments made by the Company or its Restricted Subsidiaries and repurchases and
redemptions of such Restricted Investments from the Company or its Restricted Subsidiaries and repayments of loans or advances which constitute Restricted Investments of the Company or its Restricted Subsidiaries or (B) the sale (other than to
the Company or a Restricted Subsidiary) of the Capital Stock of an Unrestricted Subsidiary or a distribution from an Unrestricted Subsidiary (other than, in each case, to the extent the Investment in such Unrestricted Subsidiary was made by a
Restricted Subsidiary pursuant to clause (10) of the next succeeding paragraph or to the extent such Investment constituted a Permitted Investment) or a dividend or other distribution from an Unrestricted Subsidiary, plus 

(e) in the case of the redesignation of an Unrestricted Subsidiary as a Restricted Subsidiary or the merger or consolidation of
an Unrestricted Subsidiary into the Company or a Restricted Subsidiary or the transfer of assets of an Unrestricted Subsidiary to the Company or a Restricted Subsidiary, the fair market value of the Investment in such Unrestricted Subsidiary, as
determined by the Board of Directors of the Company in good faith at the time of the redesignation of such Unrestricted Subsidiary as a Restricted Subsidiary or at the time of such merger, consolidation or transfer of assets (other than an
Unrestricted Subsidiary to the extent the Investment in such Unrestricted Subsidiary was made by a Restricted Subsidiary pursuant to clause (10) of the next succeeding paragraph or to the extent such Investment constituted a Permitted
Investment), plus 
 (f) $100.0 million. 

The preceding provisions will not prohibit: 

(1) the payment of any dividend or other distribution within 60 days after the date of declaration thereof, if at the date of
declaration such payment would have complied with the provisions of this Indenture; 
 (2) (A) the redemption, repurchase,
retirement or other acquisition of any Equity Interests of the Company or any direct or indirect parent of the Company (“Retired Capital Stock”) or Subordinated Indebtedness in exchange for or out of the net cash proceeds of the
substantially concurrent sale (other than to a Restricted Subsidiary or the Company) of Equity Interests of the Company or contributions to the equity capital of the Company (in each case, other than Disqualified Stock and the Cash Contribution
Amount) (“Refunding Capital Stock”) and (B) the declaration and payment of dividends on the Retired Capital Stock out of the net cash proceeds of the 

  
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substantially concurrent sale (other than to a Subsidiary of the Company or to an employee stock ownership plan or any trust established by the Company or any of its Subsidiaries) of Refunding
Capital Stock; 
 (3) the redemption, repurchase or other acquisition or retirement of Subordinated Indebtedness made by
exchange for, or out of the proceeds of the substantially concurrent sale of, new Indebtedness of the borrower thereof which is incurred in compliance with Section 4.9 so long as (A) such new Indebtedness is subordinated to the
Notes and any Guarantees thereof at least to the same extent as such Subordinated Indebtedness so redeemed, repurchased, acquired or retired, (B) such new Indebtedness has a final scheduled maturity date equal to or later than the final
scheduled maturity date of the Subordinated Indebtedness being so redeemed, repurchased, acquired or retired and (C) such new Indebtedness has a Weighted Average Life to Maturity equal to or greater than the remaining Weighted Average Life to
Maturity of the Subordinated Indebtedness being so redeemed, repurchased, acquired or retired; 
 (4) a Restricted Payment to
pay for the repurchase, retirement, redemption or other acquisition or retirement for value of Equity Interests of the Company or any of its direct or indirect parent companies held by any future, present or former employee, director or consultant
of the Company, any Subsidiary or any of its direct or indirect parent companies (or their permitted transferees, assigns, estates or heirs) pursuant to any management unit purchase agreement, management equity plan or stock option plan or any other
management or employee benefit agreement, agreement or arrangement (including, for the avoidance of doubt, any principal and interest payable on any notes issued by the Company or any direct or indirect parent company in connection with any such
repurchase, retirement or other acquisition or retirement); provided, however, that the aggregate amount of Restricted Payments made under this clause (4) does not exceed in any calendar year $35.0 million, with any unused amounts
in any calendar year being carried over to the two immediately succeeding calendar years subject to a maximum of $70.0 million in any calendar year; and provided, further, that such amount in any calendar year may be increased by an
amount not to exceed (A) the cash proceeds from the sale of Equity Interests (other than Disqualified Stock) of the Company and, to the extent contributed to the Company, Equity Interests of any of its direct or indirect parent companies, in
each case to members of management, directors or consultants of the Company, any of its Subsidiaries or any of its direct or indirect parent companies that occurs after the Issue Date plus (B) the cash proceeds of “key man” life
insurance policies received by the Company or its Restricted Subsidiaries after the Issue Date (provided that the Company may elect to apply all or any portion of the aggregate increase contemplated by clauses (A) and (B) above in
any calendar year) (it being understood that the forgiveness of any debt by such Person shall not be a Restricted Payment hereunder) less (C) the amount of any Restricted Payments previously made pursuant to clauses (A) and (B) of
this clause (4); 
 (5) the declaration and payment of dividends to holders of any class or series of Disqualified Stock of
the Company or any Restricted Subsidiary issued or incurred in accordance with Section 4.9 to the extent such dividends are included in the definition of “Fixed Charges” for such entity; 

(6) the declaration and payment of dividends or distributions to holders of any class or series of Designated Preferred Stock
(other than Disqualified Stock) issued after the Issue Date and the declaration and payment of dividends to any direct or indirect parent company of the Company the proceeds of which will be used to fund the payment of dividends to holders of any
class or series of Designated Preferred Stock (other than Disqualified Stock) of any direct or indirect parent company of the Company issued after the Issue Date; provided, however, that (A) for

  
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the most recently ended four full fiscal quarters for which internal financial statements are available immediately preceding the date of issuance of such Designated Preferred Stock, after giving
effect to such issuance (and the payment of dividends or distributions thereon) on a pro forma basis, the Company would have had a Fixed Charge Coverage Ratio of at least 2.0 to 1.0 and (B) the aggregate amount of dividends declared and paid
pursuant to this clause (6) does not exceed the net cash proceeds actually received by the Company from any such sale of Designated Preferred Stock (other than Disqualified Stock) issued after the Issue Date; 

(7) repurchases of Equity Interests deemed to occur upon exercise of stock options, warrants or similar stock-based instruments
if such Equity Interests represent a portion of the exercise price of such options, warrants or stock-based instrument or in connection with a gross-up or tax withholding related to such Equity Interests; 

(8) the payment of dividends on the Company’s common stock (or the payment of dividends to any direct or indirect parent
company of the Company, as the case may be, to fund the payment by any such parent company of the Company of dividends on such entity’s common stock) following the first public offering of the Company’s common stock or the common stock of
any of its direct or indirect parent companies after the Issue Date, of up to 6% per annum of the net cash proceeds received by or contributed to the Company after the Issue Date in any such public offering, other than public offerings of
common stock of the Company (or any direct or indirect parent company of the Company) registered on Form S-4 or Form S-8 and other than any public sale constituting an Excluded Contribution; 

(9) Investments that are made with Excluded Contributions; 

(10) other Restricted Payments after the Issue Date in an aggregate amount not to exceed $35.0 million; 

(11) distributions or payments of Receivables Fees and purchase of any assets in connection with a Receivables Facility; 

(12) the repurchase, redemption or other acquisition or retirement for value of any Subordinated Indebtedness or Disqualified
Stock pursuant to provisions similar to those described in Sections 3.9, 4.10 and 4.14; provided that a Change of Control Offer or Asset Sale Offer, as applicable, has been made and all Notes tendered by Holders of the
Notes in connection with a Change of Control Offer or Asset Sale Offer, as applicable, have been repurchased, redeemed or acquired for value; 

(13) the declaration and payment of dividends or the payment of other distributions by the Company to, or the making of loans
or advances to, any of their respective direct or indirect parents or the equity interest holders thereof in amounts required for any direct or indirect parent companies or the equity interest holders thereof to pay, in each case without
duplication, 
 (i) franchise taxes and other fees, taxes and expenses required to maintain their corporate existence; 

(ii) consolidated, combined or similar federal, foreign, state and/or local income or franchise taxes (or any alternative tax
in lieu thereof); provided, that, in each taxable year, the amount of such payments shall be equal to the amount that the Company and its Subsidiaries would have been required to pay in respect of such federal, foreign, state and/or local income or
franchise taxes if such entities were corporations paying such 

  
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taxes separately from any parent entity at the highest combined applicable federal, foreign, state, local or franchise tax rate for the applicable taxable year, but, for the avoidance of doubt,
taking into account any net operating loss carryforwards, AMT credit carryforwards or other available tax attributes of the Company and its applicable Subsidiaries; provided that any payments in respect of an Unrestricted Subsidiary shall be limited
to the amount of any cash payment made by such Unrestricted Subsidiary to the Company or any Restricted Subsidiary for such purpose; 

(iii) customary salary, bonus, severance, indemnification obligations and other benefits payable to officers and employees of
any direct or indirect parent company of the Company and any payroll, social security or similar taxes thereof to the extent such salaries, bonuses, severance, indemnification obligations and other benefits are reasonably attributable to the
ownership or operation of the Company and its Restricted Subsidiaries; 
 (iv) general corporate operating and overhead costs
and expenses of any direct or indirect parent company of the Company to the extent such costs and expenses are reasonably attributable to the ownership or operation of the Company and its Restricted Subsidiaries; 

(v) any payments required to be made by VWR Corporation to Varietal Distribution Holding, LLC pursuant to the Income Tax
Receivable Agreement; 
 (vi) fees and expenses other than to Affiliates of the Company related to (1) any equity or
debt offering of such parent entity (whether or not successful), (2) any Investment otherwise permitted under this Section 4.7 (whether or not successful) and (3) any transaction of the type described in under
Section 5.1; 
 (vii) cash payments in lieu of issuing fractional shares in connection with the exercise of
warrants, options or other securities convertible into or exchangeable for Equity Interests of the Company or any direct or indirect parent; 

(viii) amounts to finance Investments otherwise permitted to be made pursuant to this Indenture; provided, that
(1) such Restricted Payment shall be made substantially concurrently with the closing of such Investment and (2) such direct or indirect parent company shall, immediately following the closing thereof, cause (x) all property acquired
(whether assets or Equity Interests) to be contributed to the capital of the Company or one of its Restricted Subsidiaries or (y) the merger of the Person formed or acquired into the Company or one of its Restricted Subsidiaries (to the extent
not prohibited Section 5.1 in order to consummate such Investment; (3) such direct or indirect parent company and its Affiliates (other than the Company or a Restricted Subsidiary) receives no consideration or other payment in
connection with such transaction, (4) any property received by the Company shall not increase amounts available for Restricted Payments pursuant to clause (3) of the first paragraph of this Section 4.7 and (5) such Investment
shall be deemed to be made by the Company or such Restricted Subsidiary by another paragraph of this paragraph (other than pursuant to clause (9) hereof) or pursuant to the definition of “Permitted Investments” (other than clause (11)
thereof); 
 (ix) registration expenses and indemnities payable under the Registration Rights Agreement as in effect on the
Issue Date; 

  
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 (x) reasonable and customary fees payable to any directors of any direct or
indirect parent of the Company and reimbursement of reasonable out-of-pocket costs of the directors of any direct or indirect parent of the Company in the ordinary course of business, to the extent reasonably attributable to the ownership or
operation of the Company and its Restricted Subsidiaries; and 
 (xi) reasonable and customary indemnities to directors,
officers and employee of any direct or indirect parent of the Company in the ordinary course of business, to the extent reasonably attributable to the ownership or operation of the Company and its Restricted Subsidiaries; 

(14) cash payments in lieu of the issuance of fractional shares in connection with the exercise of warrants, options or other
securities convertible into or exchangeable for Equity Interests of the Company; provided, however, that any such cash payment shall not be for the purpose of evading the limitation of this Section 4.7 (as determined in
good faith by the Board of Directors of the Company); 
 (15) distributions, by dividends or otherwise, of Capital Stock of,
or Indebtedness owed to the Company or a Restricted Subsidiary by, Unrestricted Subsidiaries; 
 (16) cash dividends or other
distributions on the Company’s or any Restricted Subsidiary’s Capital Stock used to, or the making of loans the proceeds of which will be used to, fund the payment of fees and expenses, including indemnification obligations, incurred in
connection with this offering, in each case to the extent permitted (to the extent applicable) by Section 4.11; 

(17) payments or distributions in connection with an AHYDO “catch-up” payment with respect to Indebtedness permitted
to be incurred hereunder; 
 (18) any Restricted Payment used to fund the Transactions and the Transaction Expenses; 

(19) Investments in Unrestricted Subsidiaries having an aggregate fair market value, taken together with all other Investments
made pursuant to this clause (19) that are at the time outstanding, without giving effect to any distribution pursuant to clause (15) of this paragraph or the sale of an Unrestricted Subsidiary to the extent the proceeds of such sale do
not consist of cash or marketable securities, not to exceed 1.5% of Total Net Tangible Assets at the time of such Investment (with the fair market value of each Investment being measured at the time made and without giving effect to subsequent
changes in value); and 
 (20) payments and distributions to dissenting stockholders pursuant to applicable law, pursuant to
or in connection with a consolidation, merger or transfer of all or substantially all of the assets of the Company and its Restricted Subsidiaries taken as a whole that complies with the terms of this Indenture, including Section 5.1;

 provided, however, that at the time of, and after giving effect to, any Restricted Payment permitted under clauses (5), (6), (8), (10),
(12), (13)(v) and (vi) and (19) above, no default which, with the passage of time would be an Event of Default, or an Event of Default shall have occurred and be continuing or would occur as a consequence thereof. 

The amount of all Restricted Payments (other than cash) will be the fair market value on the date of the Restricted Payment of the asset(s) or
securities proposed to be transferred or issued by the Company 

  
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or such Subsidiary, as the case may be, pursuant to the Restricted Payment. The fair market value of any assets or securities that are required to be valued by this Section 4.7 will
be determined in good faith by the Board of Directors of the Company. 
 As of the Issue Date, all of the Company’s Subsidiaries will
be Restricted Subsidiaries. The Company will not permit any Unrestricted Subsidiary to become a Restricted Subsidiary except pursuant to the second to last sentence of the definition of “Unrestricted Subsidiary.” For purposes of
designating any Restricted Subsidiary as an Unrestricted Subsidiary, all outstanding investments by the Company and the Restricted Subsidiaries (except to the extent repaid) in the Subsidiary so designated will be deemed to be Restricted Payments in
an amount determined as set forth in the second paragraph of the definition of “Investments.” Such designation will be permitted only if a Restricted Payment in such amount would be permitted at such time under this Section 4.7
or the definition of “Permitted Investments” and if such Subsidiary otherwise meets the definition of an Unrestricted Subsidiary. Unrestricted Subsidiaries will not be subject to any of the restrictive covenants of this Indenture. 

For the avoidance of doubt, any dividend or distribution otherwise permitted pursuant to this Section 4.7 may be in the form of a
loan. 
 SECTION 4.8 Limitation on Dividends and Other Payment Restrictions Affecting Subsidiaries. 

The Company will not, and will not permit any of its Restricted Subsidiaries to, directly or indirectly, create or permit to exist or become
effective any consensual encumbrance or restriction on the ability of any such Restricted Subsidiary to: 
 (1) pay dividends
or make any other distributions on its Capital Stock to the Company or any of its Restricted Subsidiaries, or with respect to any other interest or participation in, or measured by, its profits, or pay any Indebtedness owed to the Company or any of
its Restricted Subsidiaries; 
 (2) make loans or advances to the Company or any of its Restricted Subsidiaries; or 

(3) sell, lease or transfer any of its properties or assets to the Company or any of its Restricted Subsidiaries. 

However, the preceding restrictions will not apply to encumbrances or restrictions existing under or by reason of: 

(1) contractual encumbrances or restrictions in effect (x) pursuant to a Credit Facility or related documents as in effect
on the Issue Date or (y) on the Issue Date, including, without limitation, pursuant to Indebtedness in existence on the Issue Date; 

(2) this Indenture, the Notes and Guarantees; 

(3) [reserved]; 

(4) purchase money obligations or other obligations described in clause (5) of the second paragraph of
Section 4.9 that, in each case, impose restrictions of the nature discussed in clause (3) above in the first paragraph of this Section 4.8 on the property so acquired; 

(5) applicable law or any applicable rule, regulation or order; 

  
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 (6) any agreement or other instrument of a Person acquired by the Company or any
Restricted Subsidiary in existence at the time of such acquisition or at the time a Restricted Subsidiary is first designated as a Restricted Subsidiary (but not created in connection therewith or in contemplation thereof or to provide all or a
portion of the funds or credit support utilized to consummate such acquisition), which encumbrance or restriction is not applicable to any Person, or the properties or assets of any Person, other than the Person, or the property or assets of the
Person, so acquired; 
 (7) contracts for the sale of assets, including without limitation, customary restrictions with
respect to a Subsidiary pursuant to an agreement that has been entered into for the sale or disposition of all or substantially all of the Capital Stock or assets of such Subsidiary; 

(8) Secured Indebtedness otherwise permitted to be incurred pursuant to Sections 4.9 and 4.12 that limits the
right of the debtor to dispose of the assets securing such Indebtedness; 
 (9) restrictions on cash or other deposits or net
worth imposed by customers under contracts entered into in the ordinary course of business; 
 (10) other Indebtedness or
Preferred Stock of any Restricted Subsidiary (i) that is a Guarantor that is incurred subsequent to the Issue Date pursuant to Section 4.9 or (ii) that is incurred by a Foreign Subsidiary of the Company subsequent to the Issue
Date pursuant to Section 4.9; 
 (11) customary provisions in joint venture agreements and other similar
agreements entered into in the ordinary course of business; 
 (12) customary provisions contained in leases, subleases,
licenses or asset sale agreements and other agreements; 
 (13) restrictions and conditions by the terms of the documentation
governing any Receivables Facility that in the good faith determination of the Company are necessary or advisable to effect such Receivables Facility; 

(14) negative pledges and restrictions on Liens in favor of any holder of Indebtedness permitted under this Indenture; and 

(15) any encumbrances or restrictions of the type referred to in clauses (1), (2) and (3) of the first paragraph of
this Section 4.8 imposed by any amendments, modifications, restatements, renewals, increases, supplements, refundings, replacements or refinancings of the contracts, instruments or obligations referred to in clauses (1) through
(14) above; provided that the encumbrances or restrictions imposed by such amendments, modifications, restatements, renewals, increases, supplements, refundings, replacements or refinancings are, in the good faith judgment of the Board
of Directors of the Company, not materially less favorable to the Holders of the Notes than encumbrances and restrictions contained in such predecessor agreements and do not affect the Company’s and Guarantors’ ability, taken as a whole,
to make payments of interest and scheduled payments of principal in respect of the Notes, in each case as and when due; provided further, however, that with respect to agreements existing on the Issue Date, any
refinancings or amendments thereof contain such encumbrances or restrictions that are not materially less favorable to the Holders of the Notes than the encumbrances or restrictions contained in such agreements as in effect on the Issue Date. 

  
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 SECTION 4.9 Limitation on Incurrence of Indebtedness and Issuance of Preferred Stock. 

The Company will not, and will not permit any of its Restricted Subsidiaries to, directly or indirectly, create, incur, issue, assume,
guarantee or otherwise become directly or indirectly liable, contingently or otherwise, with respect to (collectively “incur”) any Indebtedness (including Acquired Debt) and will not permit any of its Restricted Subsidiaries to
issue any shares of Preferred Stock; provided, however, that the Company and any Restricted Subsidiary may incur Indebtedness (including Acquired Debt) and any Restricted Subsidiary may issue Preferred Stock if the Fixed Charge
Coverage Ratio of the Company and its Restricted Subsidiaries (on a consolidated basis) for the Company’s most recently ended four full fiscal quarters for which internal financial statements are available immediately preceding the date on
which such additional Indebtedness is incurred or such Preferred Stock is issued would have been at least 2.0 to 1.0 determined on a pro forma basis (including a pro forma application of the net proceeds therefrom), as if the additional Indebtedness
had been incurred or the Preferred Stock had been issued, as the case may be, and the application of proceeds therefrom had occurred at the beginning of such four-quarter period; provided further, that any incurrence of Indebtedness or
issuance of Preferred Stock by a Restricted Subsidiary that is not a Guarantor pursuant to this paragraph is subject to the limitations of set forth in the sixth paragraph of this Section 4.9. 

The first paragraph of this Section 4.9 will not prohibit the incurrence of any of the following (collectively, “Permitted
Debt”): 
 (1) the incurrence by the Company or a Restricted Subsidiary of Indebtedness under Credit Facilities
together with the incurrence by the Company or any Restricted Subsidiary of the guarantees thereunder and the issuance and creation of letters of credit and bankers’ acceptances thereunder (with letters of credit and bankers’ acceptances
being deemed to have a principal amount equal to the face amount thereof), up to an aggregate principal amount, equal to (A) $2,420 million minus (B) the aggregate principal amount of Indebtedness incurred by a Receivables
Subsidiary and then outstanding pursuant to clause (18) of this paragraph or by a Foreign Subsidiary and then outstanding pursuant to clause (27)(B) of this paragraph that was used to permanently reduce commitments under a Credit Facility,
minus (C) the amount of all mandatory principal payments actually made by the borrower thereunder in respect of Indebtedness thereunder with Net Proceeds from Asset Sales; 

(2) the incurrence by the Company and the Guarantors of Indebtedness represented by the Notes (including any Guarantee thereof)
on the Issue Date; 
 (3) [reserved]; 

(4) any Indebtedness of the Company and its Restricted Subsidiaries in existence on the Issue Date (including the Existing
Notes) (other than Indebtedness described in clauses (1) or (2) above); 
 (5) Indebtedness (including Capitalized
Lease Obligations) incurred by the Company or any Restricted Subsidiary to finance the purchase, construction, lease or improvement of property (real or personal) or equipment that is used or useful in a Permitted Business (whether through the
direct purchase of assets or the Capital Stock of any Person owning such assets) in an aggregate principal amount that, when aggregated with the principal amount of all other Indebtedness then outstanding and incurred pursuant to this clause
(5) does not exceed $70.0 million; 
 (6) Indebtedness incurred by the Company or any Restricted Subsidiary constituting
reimbursement obligations with respect to letters of credit issued in the ordinary course of business, 

  
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including without limitation letters of credit in respect of workers’ compensation claims, health, disability or other employee benefits or property, casualty or liability insurance or
self-insurance or other Indebtedness with respect to reimbursement-type obligations regarding workers’ compensation claims; provided, however, that upon the drawing of such letters of credit or the incurrence of such Indebtedness,
such obligations are reimbursed within 45 days following such drawing or incurrence; 
 (7) Indebtedness arising from
agreements of the Company or a Restricted Subsidiary providing for indemnification, adjustment of purchase price, earn-outs or similar obligations, in each case, incurred or assumed in connection with the disposition or acquisition of any business,
assets or a Subsidiary, other than guarantees of Indebtedness incurred by any Person acquiring all or any portion of such business, assets or a Subsidiary for the purpose of financing such acquisition; provided, however, that such
Indebtedness is not reflected on the balance sheet (other than by application of FIN 45 as a result of an amendment to an obligation in existence on the Issue Date) of the Company or any Restricted Subsidiary (contingent obligations referred to in a
footnote to financial statements and not otherwise reflected on the balance sheet will not be deemed to be reflected on such balance sheet for purposes of this clause (7)); 

(8) Indebtedness of the Company owed to and held by any Restricted Subsidiary or Indebtedness of a Restricted Subsidiary owed
to and held by the Company or any other Restricted Subsidiary; provided, however, that (A) any subsequent issuance or transfer of any Capital Stock or any other event that results in any such Restricted Subsidiary ceasing to be a
Restricted Subsidiary or any subsequent transfer of any such Indebtedness (except to the Company or a Restricted Subsidiary or any pledge of such Indebtedness constituting a Permitted Lien) shall be deemed, in each case, to constitute the incurrence
of such Indebtedness not permitted by this clause (8) and (B) if the Company or a Guarantor is the obligor on such Indebtedness, such Indebtedness is expressly subordinated in right of payment to all obligations of the Company or such
Guarantor with respect to the Notes; 
 (9) shares of Preferred Stock of a Restricted Subsidiary issued to the Company or a
Restricted Subsidiary; provided that any subsequent issuance or transfer of any Capital Stock or any other event which results in any such Restricted Subsidiary ceasing to be a Restricted Subsidiary or any other subsequent transfer of any
such shares of Preferred Stock (except to the Company or a Restricted Subsidiary) shall be deemed in each case to be an issuance of such shares of Preferred Stock not permitted by this clause (9); 

(10) Hedging Obligations of the Company or any Restricted Subsidiary (excluding Hedging Obligations entered into for
speculative purposes); 
 (11) obligations in respect of customs, stay, bid, appeal, performance and surety bonds, appeal
bonds and other similar types of bonds and performance and completion guarantees and other obligations of a like nature provided by the Company or any Restricted Subsidiary or obligations in respect of letters of credit related thereto, in each case
in the ordinary course of business or consistent with past practice; 
 (12) Indebtedness of the Company or any Restricted
Subsidiary or Preferred Stock of any Restricted Subsidiary not otherwise permitted hereunder in an aggregate principal amount or liquidation preference which, when aggregated with the principal amount and liquidation preference of all other
Indebtedness and Preferred Stock then outstanding and incurred pursuant to this clause (12) does not at any one time outstanding exceed $135.0 million; provided, that any Indebtedness 

  
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or Preferred Stock incurred pursuant to this clause (12) shall cease to be deemed incurred or outstanding for purposes of this clause (12) but shall be deemed incurred for the purposes
of the first paragraph of this Section 4.9 from and after the first date on which the Company or such Restricted Subsidiary could have incurred such Indebtedness or issued such Disqualified Stock or Preferred Stock under the first
paragraph of this Section without reliance on this clause (12); 
 (13) (x) any guarantee by the Company or a Restricted
Subsidiary of Indebtedness or other obligations of any Restricted Subsidiary so long as the incurrence of such Indebtedness incurred by such Restricted Subsidiary is permitted under the terms of this Indenture; provided that if such
Indebtedness is by its express terms subordinated in right of payment to the Notes or the Guarantee of such Restricted Subsidiary or the Company, as applicable, any such guarantee of such Guarantor with respect to such Indebtedness shall be
subordinated in right of payment to such Guarantor’s Guarantee with respect to the Notes substantially to the same extent as such Indebtedness is subordinated to the Notes or the Guarantee of such Restricted Subsidiary, as applicable, and
(y) any guarantee by a Restricted Subsidiary of Indebtedness of the Company incurred in accordance with the terms of this Indenture; 

(14) the incurrence by the Company or any Restricted Subsidiary of Indebtedness or Preferred Stock that serves to refund,
replace or refinance any Indebtedness incurred as permitted under the first paragraph of this Section 4.9 and clauses (2) and (4) above, this clause (14) and clauses (15) and (20) below or any Indebtedness issued
to so refund, replace or refinance such Indebtedness including additional Indebtedness incurred to pay premiums and fees in connection therewith (the “Refinancing Indebtedness”) prior to its respective maturity; provided,
however, that such Refinancing Indebtedness (A) has a Weighted Average Life to Maturity at the time such Refinancing Indebtedness is incurred which is not less than the Weighted Average Life to Maturity of the Indebtedness being refunded
or refinanced, (B) to the extent such Refinancing Indebtedness refinances Subordinated Indebtedness or Indebtedness pari passu to the Notes or the Guarantees, such Refinancing Indebtedness is subordinated or pari
passu to the Notes or the Guarantees at least to the same extent as the Indebtedness being refinanced or refunded, (C) shall not include (x) Indebtedness or Preferred Stock of a Subsidiary that is not a Guarantor that refinances
Indebtedness or Preferred Stock of the Company or a Guarantor or (y) Indebtedness or Preferred Stock of the Company or a Restricted Subsidiary that refinances Indebtedness or Preferred Stock of an Unrestricted Subsidiary, and (D) shall not
be in a principal amount in excess of the principal amount of, premium, if any, deemed interest on, and related fees and expenses of, the Indebtedness being refunded, replaced or refinanced; 

(15) (i) Indebtedness or Preferred Stock of a Person incurred and outstanding on or prior to the date on which such Person was
acquired by, the Company or any Restricted Subsidiary or merged into the Company or a Restricted Subsidiary in accordance with the terms of this Indenture or (ii) Indebtedness of the Company or any Restricted Subsidiary incurred in connection
with or in contemplation of, or to provide all or any portion of the funds or credit support utilized to consummate, the acquisition by the Company or such Restricted Subsidiary of property used or useful in a Permitted Business (whether through the
direct purchase of assets or the purchase of Capital Stock of, or merger or consolidation with, any Person owning such assets); provided, that after giving effect to such incurrence of Indebtedness either (A) the Company would be
permitted to incur at least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test set forth in the first paragraph of this Section 4.9 or (B) the Fixed Charge Coverage Ratio would be at least equal to or
greater than such Fixed Charge Coverage Ratio immediately prior to such acquisition; 

  
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 (16) Indebtedness arising from the honoring by a bank or financial institution of
a check, draft or similar instrument drawn against insufficient funds in the ordinary course of business; provided that such Indebtedness is extinguished within five Business Days of its incurrence; 

(17) Indebtedness of the Company or any of its Restricted Subsidiaries supported by a letter of credit issued pursuant to a
Credit Facility in a principal amount not in excess of the stated amount of such letter of credit; 
 (18) Indebtedness
incurred by a Receivables Subsidiary in connection with a Receivables Facility; 
 (19) Indebtedness consisting of promissory
notes issued by the Company or any Guarantor to current or former officers, directors, consultants and employees, their respective estates, spouses, former spouses, heirs or family members to finance the purchase or redemption of Equity Interests of
Company or any of its direct or indirect parent companies permitted by Section 4.7; 
 (20) Contribution
Indebtedness (it being understood that any Contribution Indebtedness issued pursuant to this clause (20) shall cease to be deemed incurred or outstanding for purposes of this clause (20) but shall be deemed incurred for the purposes of the
first paragraph of this Section 4.9 from and after the first date on which the Company or such Restricted Subsidiary could have incurred such Contribution Indebtedness under the first paragraph of this Section 4.9 without
reliance on this clause (20)); 
 (21) Indebtedness of the Company or any Restricted Subsidiary to the extent the proceeds of
such Indebtedness are deposited and used to defease the Notes as described in Article VIII hereof; 
 (22)
Indebtedness of the Company or any Restricted Subsidiary consisting of (i) the financing of insurance premiums or (ii) take or pay obligations contained in supply agreements, in each case incurred in the ordinary course of business; 

(23) [reserved]; 

(24) cash management obligations and Indebtedness in respect of netting services, overdraft facilities, employee credit card
programs, Cash Pooling Arrangements or similar arrangements in connection with cash management and deposit accounts; provided that, with respect to any Cash Pooling Arrangements, the total amount of all deposits subject to any such Cash
Pooling Arrangement at all times equals or exceeds the total amount of overdrafts that may be subject to such Cash Pooling Arrangements; 

(25) Indebtedness of the Company or any of its Restricted Subsidiaries in respect of Sale and Lease-Back Transactions; 

(26) Indebtedness representing deferred compensation to employees of the Company or any Restricted Subsidiary incurred in the
ordinary course of business; and 
 (27) Indebtedness or Preferred Stock of any Foreign Subsidiary: (A) incurred under
local credit facilities for general corporate purposes not exceeding, as to all such Foreign Subsidiaries, $70.0 million in the aggregate at any one time outstanding or (B) which serves to refund or refinance any Indebtedness incurred under
clause (1) or (2) of this paragraph or the payment of any dividend to the Company or any Restricted Subsidiary in a principal amount not to exceed $250.0 million in the aggregate at any one time outstanding. 

  
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 For purposes of determining compliance with this Section 4.9 in the event that an
item of proposed Indebtedness meets the criteria of more than one of the categories of Permitted Debt described in clauses (1) through (27) above, or is entitled to be incurred pursuant to the first paragraph of this
Section 4.9, the Company will be permitted to classify and later reclassify such item of Indebtedness in any manner that complies with this Section 4.9, and such item of Indebtedness will be treated as having been incurred
pursuant to only one of such categories. Accrual of interest or dividends, the accretion of accreted value and the payment of interest or dividends in the form of additional Indebtedness or Preferred Stock will not be deemed to be an incurrence of
Indebtedness or Preferred Stock for purposes of this Section 4.9 and Section 4.12. Notwithstanding the foregoing, Indebtedness under the Credit Agreement outstanding on the Issue Date will be deemed to have been incurred on
such date in reliance on the exception provided by clause (1) of the definition of “Permitted Debt” and any such Indebtedness that was outstanding under the Credit Agreement as of the Issue Date may not later be reclassified.
Additionally, all or any portion of any other item of Indebtedness may later be reclassified as having been incurred pursuant to the first paragraph of this Section 4.9 or under any category of Permitted Debt described in clauses
(1) through (27) above so long as such Indebtedness is permitted to be incurred pursuant to such provision at the time of reclassification. 

For purposes of determining compliance with any U.S. dollar restriction on the incurrence of Indebtedness where the Indebtedness incurred is
denominated in a different currency, the amount of such Indebtedness will be the U.S. Dollar Equivalent determined on the date of the incurrence of such Indebtedness; provided, however, that if any such Indebtedness denominated in
a different currency is subject to a currency agreement with respect to U.S. dollars covering all principal, premium, if any, and interest payable on such Indebtedness, the amount of such Indebtedness expressed in U.S. dollars will be as provided in
such currency agreement. The principal amount of any refinancing Indebtedness incurred in the same currency as the Indebtedness being refinanced will be the U.S. Dollar Equivalent of the Indebtedness being refinanced, except to the extent that
(1) such U.S. Dollar Equivalent was determined based on a currency agreement, in which case the refinancing Indebtedness will be determined in accordance with the preceding sentence, and (2) the principal amount of the refinancing
Indebtedness exceeds the principal amount of the Indebtedness being refinanced, in which case the U.S. Dollar Equivalent of such excess will be determined on the date such refinancing Indebtedness is incurred. The maximum amount of Indebtedness
that the Company and its Restricted Subsidiaries may incur pursuant to this Section 4.9 shall not be deemed to be exceeded, with respect to any outstanding Indebtedness, solely as a result of fluctuations in the exchange rate of
currencies. 
 The Company shall not, and shall not permit any Restricted Subsidiary that is a Guarantor to, directly or indirectly, incur
any Indebtedness that is or purports to be by its terms (or by the terms of any agreement governing such Indebtedness) contractually subordinated or junior in right of payment to any Indebtedness (including Acquired Debt) of the Company or such
Restricted Subsidiary, as the case may be, unless such Indebtedness is also by its terms (or by the terms of any agreement governing such Indebtedness) made expressly subordinate to the Notes to the extent and in the same manner as such Indebtedness
is subordinated to other Indebtedness of the Company or such Guarantor’s Guarantee of the Notes (as applicable). Indebtedness shall not be considered subordinate or junior in right of payment by virtue of being secured to a greater or lesser
extent or with different priority. 
 Notwithstanding anything to the contrary contained in the first paragraph of this
Section 4.9 or in the definition of Permitted Debt, no Restricted Subsidiary of the Company that is not a Guarantor shall incur any Indebtedness or issue any Preferred Stock in reliance on the first paragraph of this
Section 4.9 

  
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or clause (15) of the definition of “Permitted Debt” (the “Limited Non-Guarantor Debt Exceptions”) if the amount of such Indebtedness or Preferred Stock, when
aggregated with the amount of all other Indebtedness or Preferred Stock outstanding under such Limited Non-Guarantor Debt Exceptions, together with any Refinancing Indebtedness in respect thereof, would exceed $135.0 million; provided, that
in no event shall any Indebtedness or Preferred Stock of any Restricted Subsidiary that is not a Guarantor (x) existing at the time it became a Restricted Subsidiary or (y) assumed in connection with any acquisition, merger or acquisition
of minority interests of a non-Wholly Owned Subsidiary (and in the case of clauses (x) and (y), not created in contemplation of such Person becoming a Restricted Subsidiary or such acquisition, merger or acquisition of minority interests) be
deemed to be Indebtedness outstanding under the Limited Non-Guarantor Debt Exceptions for purposes of this paragraph. 
 SECTION 4.10
Limitation on Asset Sales. 
 The Company will not, and will not permit any of its Restricted Subsidiaries to, consummate an Asset
Sale unless: 
 (1) the Company (or such Restricted Subsidiary, as the case may be) receives consideration at the time of the
Asset Sale at least equal to the fair market value of the assets or Equity Interests issued or sold or otherwise disposed of; and 

(2) at least 75% of the consideration received in the Asset Sale by the Company or such Restricted Subsidiary is in the form of
cash or Cash Equivalents. 
 For purposes of clause (2) above, the amount of (i) any liabilities other than contingent liabilities
(as shown on the Company’s or the applicable Restricted Subsidiary’s most recent balance sheet or in the notes thereto) of the Company or any Restricted Subsidiary (other than liabilities that are by their terms subordinated to the Notes
or the Guarantees) that are assumed by the transferee of any such assets and from which the Company and all Restricted Subsidiaries have been validly released by the applicable creditor(s) in writing, (ii) any securities received by the Company
or such Restricted Subsidiary from such transferee that are converted by the Company or Restricted Subsidiary into cash (to the extent of the cash received) within 180 days following the closing of such Asset Sale, (iii) any assets described in
clauses (2) or (3) below, and (iv) any Designated Non-cash Consideration received by the Company or any of its Restricted Subsidiaries in such Asset Sale having an aggregate fair market value (as determined in good faith by the Board
of Directors of the Company), taken together with all other Designated Non-cash Consideration received pursuant to this clause (iv) that is at that time outstanding, not to exceed the greater of (x) $100.0 million and (y) an amount
equal to 2% of Total Assets of the Company on the date on which such Designated Non-cash Consideration is received (with the fair market value of each item of Designated Non-cash Consideration being measured at the time received without giving
effect to subsequent changes in value), shall be deemed to be cash for purposes of this paragraph and for no other purpose. 
 Within 365
days after the receipt of any Net Proceeds from an Asset Sale, the Company or such Restricted Subsidiary, as the case may be, may apply those Net Proceeds at its option: 

(1) (i) to reduce Obligations under Secured Indebtedness of the Company or any Restricted Subsidiary, (ii) to reduce
Obligations under Indebtedness of a Restricted Subsidiary that is not a Guarantor (other than Indebtedness owed to the Company or another Restricted Subsidiary), (iii) to reduce Obligations under any Indebtedness outstanding under the Credit
Facilities (other than Subordinated Indebtedness) or (iv) to reduce Indebtedness of the Company that ranks pari passu with the Notes or Indebtedness of a Guarantor that ranks pari passu with such Guarantor’s
Guarantee of the Notes (provided that if the Company shall so reduce Obligations under Indebtedness that ranks pari passu with the Notes (other than Indebtedness specified in clauses
(i)

  
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through (iii) above), it will equally and ratably reduce Obligations under the Notes through open-market purchases (to the extent such purchases are at or above 100% of the principal amount
thereof) or by causing the Company to make an offer (in accordance with the procedures set forth below in this Section 4.10) to all Holders of Notes to purchase at a purchase price equal to 100% of the principal amount thereof, plus
accrued and unpaid interest on the pro rata principal amount of Notes), in each case other than Indebtedness owed to Parent or any Restricted Subsidiary; 

(2) to an investment in (A) any one or more businesses; provided that such investment in any business is in the
form of the acquisition of Capital Stock and results in the Company or a Restricted Subsidiary owning an amount of the Capital Stock of such business such that such business constitutes a Restricted Subsidiary, (B) capital expenditures or
(C) other non-current assets, in each of (A), (B) and (C), used or useful in a Permitted Business; and/or 
 (3) to
an investment in (A) any one or more businesses; provided that such investment in any business is in the form of the acquisition of Capital Stock and results in the Company or a Restricted Subsidiary owning an amount of the Capital Stock
of such business such that such business constitutes a Restricted Subsidiary, (B) properties or (C) assets that, in each of (A), (B) and (C), replace the businesses, properties and assets that are the subject of such Asset Sale. 

Any Net Proceeds from an Asset Sale not applied or invested in accordance with the preceding paragraph within 365 days from the date of the
receipt of such Net Proceeds shall constitute “Excess Proceeds”; provided that if during such 365-day period the Company or a Restricted Subsidiary enters into a definitive binding agreement committing it to apply such Net
Proceeds in accordance with the requirements of clause (2) or (3) of the immediately preceding paragraph after such 365th day, such 365-day period will be extended with respect to the amount of Net Proceeds so committed for a period not to
exceed 180 days until such Net Proceeds are required to be applied in accordance with such agreement (or, if earlier, until termination of such agreement). 

When the aggregate amount of Excess Proceeds exceeds $25.0 million, the Company or the applicable Restricted Subsidiary will make an offer (an
“Asset Sale Offer”) to all Holders of Notes and Indebtedness that ranks pari passu with the Notes and contains provisions similar to those set forth in this Indenture with respect to offers to purchase with the
proceeds of sales of assets to purchase, on a pro rata basis, the maximum principal amount of Notes and such other Indebtedness that ranks pari passu with the Notes that may be purchased out of the Excess Proceeds. The
offer price in any Asset Sale Offer will be equal to 100% of the principal amount thereof, plus accrued and unpaid interest, if any, to the date of purchase, and will be payable in cash. 

Pending the final application of any Net Proceeds, the Company or the applicable Restricted Subsidiary may temporarily reduce revolving credit
borrowings or otherwise invest the Net Proceeds in any manner that is not prohibited by this Indenture. 
 If any Excess Proceeds remain
after consummation of an Asset Sale Offer, the Company or the applicable Restricted Subsidiary may use those Excess Proceeds for any purpose not otherwise prohibited by this Indenture. If the aggregate principal amount of Notes tendered into such
Asset Sale Offer exceeds the amount of Excess Proceeds, the Registrar will select the Notes to be purchased on a pro rata basis. Upon completion of each Asset Sale Offer, the amount of Excess Proceeds will be reset at zero. 

The Company or the applicable Restricted Subsidiary will comply with the requirements of Rule 14e-1 under the Exchange Act and any other
securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with each repurchase of Notes pursuant to an Asset Sale Offer. To the extent that the provisions of any securities laws or regulations
conflict with the Asset Sale 

  
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provisions of this Indenture, the Company or the applicable Restricted Subsidiary will comply with the applicable securities laws and regulations and will not be deemed to have breached its
obligations under the Asset Sale provisions of this Indenture by virtue of such conflict. 
 SECTION 4.11 Limitation on Transactions with
Affiliates. 
 The Company will not, and will not permit any of its Restricted Subsidiaries to, make any payment to, or sell, lease,
assign, transfer or otherwise dispose of any of its properties or assets to, or purchase any property or assets from, or enter into or make or amend any transaction, contract, agreement, understanding, loan, advance or guarantee with, or for the
benefit of, any Affiliate (each, an “Affiliate Transaction”) involving aggregate consideration in excess of $15.0 million, unless: 

(1) the Affiliate Transaction is on terms that are not materially less favorable to the Company or the relevant Restricted
Subsidiary than those that would have been obtained in a comparable transaction by the Company or Restricted Subsidiary with an unrelated Person; and 

(2) with respect to any Affiliate Transaction or series of related Affiliate Transactions involving aggregate consideration in
excess of $35.0 million, a majority of the Board of Directors of the Company (and, if any, a majority of the disinterested members of the Board of Directors of the Company with respect to such Affiliate Transaction) have determined in good faith
that the criteria set forth in the immediately preceding clause (1) are satisfied and have approved the relevant Affiliate Transaction as evidenced by a Board Resolution. 

The following items will not be deemed to be Affiliate Transactions and, therefore, will not be subject to the provisions of the prior
paragraph: 
 (1) any transaction with the Company, a Restricted Subsidiary or joint venture or similar entity which would
constitute an Affiliate Transaction solely because the Company or a Restricted Subsidiary owns an equity interest in or otherwise controls such Restricted Subsidiary, joint venture or similar entity; 

(2) Restricted Payments and Permitted Investments permitted by this Indenture; 

(3) [reserved]; 

(4) payments in respect of employment, severance and any other compensation arrangements with, and fees and expenses paid to,
and indemnities provided on behalf of (and entering into related agreements with) officers, directors, employees or consultants of the Company, any of its direct or indirect parent companies, or any Restricted Subsidiary, in the ordinary course of
business; 
 (5) payments made by the Company or any Restricted Subsidiary to the Sponsor for any financial advisory,
financing, underwriting or placement services or in respect of other investment banking activities, including, without limitation, in connection with acquisitions or divestitures, which payments are approved by majority of the Board of Directors of
the Company (and, if any, a majority of the disinterested members of the Board of Directors of the Company with respect to such Affiliate Transaction) in good faith; 

(6) transactions in which the Company or any Restricted Subsidiary delivers to the Trustee a letter from an Independent
Financial Advisor stating that such transaction is fair to the Company or such Restricted Subsidiary from a financial point of view or meets the requirements of clause (1) of the first paragraph of this Section 4.11; 

  
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 (7) payments or loans (or cancellations of loans) to employees or consultants of
the Company or any of its direct or indirect parent companies or any Restricted Subsidiary which are approved by the Board of Directors of the Company in good faith and which are otherwise permitted under this Indenture; 

(8) payments made or performance under any agreement as in effect on the Issue Date that are disclosed in the Offering Circular
(including the Registration Rights Agreement), including with additional parties that may be added subsequent to the Issue Date and any amendment thereto to the extent such an amendment is not adverse to the interests of the Holders of the Notes in
any material respect; 
 (9) transactions with customers, clients, suppliers, or purchasers or sellers of goods or services
(including Parent and its Subsidiaries), in each case in the ordinary course of business and otherwise in compliance with the terms of this Indenture that are fair to the Company or its Restricted Subsidiaries, in the reasonable determination of the
members of the Board of Directors of the Company or the senior management thereof, or are on terms at least as favorable as would reasonably have been entered into at such time with an unaffiliated party; 

(10) if otherwise permitted hereunder, the issuance of Equity Interests (other than Disqualified Stock) of the Company to any
Permitted Holder, any director, officer, employee or consultant of the Company or its Subsidiaries or any other Affiliates of the Company (other than a Subsidiary); 

(11) any transaction permitted by Section 5.1; 

(12) any transaction with a Receivables Subsidiary effected as part of a Receivables Facility; 

(13) the Transactions and the payment of the Transaction Expenses; 

(14) payments by the Company and its Restricted Subsidiaries to each other pursuant to tax sharing agreements or arrangements
among Parent and its subsidiaries on customary terms (including, without limitation, transfer pricing initiatives); and 

(15) transactions among Foreign Subsidiaries for tax planning and tax efficiency purposes. 

SECTION 4.12 Limitation on Liens. 

The Company will not, and will not permit any of its Restricted Subsidiaries that are Guarantors to, directly or indirectly, create, incur,
assume or suffer to exist any Lien that secures obligations under any Indebtedness ranking pari passu with or subordinated to the Notes or, if applicable, any related Guarantee on any asset or property of the Company or any Restricted
Subsidiary, or any income or profits therefrom, or assign or convey any right to receive income therefrom, unless: 
 (1) in
the case of Liens securing Subordinated Indebtedness, the Notes and any related Guarantees are secured by a Lien on such property, assets or proceeds that is senior in priority to such Liens; or 

  
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 (2) in all other cases, the Notes and any related Guarantees are equally and
ratably secured, except that the foregoing shall not apply to: 
 (i) Liens existing on the Issue Date to the extent and in
the manner such Liens are in effect on the Issue Date; 
 (ii) (A) Liens securing the Notes and the related Guarantees and
secured by a Lien (in each case in accordance with the terms of this Indenture) and the related Guarantees, (B) Liens securing Indebtedness and related Obligations permitted to be incurred pursuant to clauses (1) and (5) of the
definition of “Permitted Debt” and (C) Liens securing Indebtedness and related Obligations permitted to be incurred pursuant to Section 4.9; provided that with respect to clause (C), at the time of incurrence such
secured Indebtedness does not exceed the maximum principal amount of Indebtedness that, as of such date, and after giving effect to the incurrence of such Indebtedness and the application of the proceeds therefrom on such date, would not cause the
Secured Indebtedness Leverage Ratio of the Company to exceed 5.0 to 1.0; or 
 (iii) Permitted Liens. 

Any Lien created for the benefit of the Holders of the Notes pursuant to this Section 4.12 shall be deemed automatically and
unconditionally released and discharged upon the release and discharge of each of the Liens described in clauses (1) and (2) above. 

For purposes of determining compliance with this Section 4.12, (A) a Lien securing an item of Indebtedness need not be
permitted solely by reference to one category of Permitted Liens described in clauses (1) through (37) of the definition of “Permitted Liens” or pursuant to the first paragraph of this Section 4.12 but may be
permitted in part under any combination thereof and (B) in the event that a Lien securing an item of Indebtedness (or any portion thereof) meets the criteria of one or more of the categories of Permitted Liens described in clauses
(1) through (37) of the definition of “Permitted Liens” or pursuant to the first paragraph of this Section 4.12, the Company shall, in its sole discretion, classify or reclassify, or later divide, classify or
reclassify, such Lien securing such item of Indebtedness (or any portion thereof) in any manner that complies with this Section 4.12 and will only be required to include the amount and type of such Lien or such item of Indebtedness
secured by such Lien in one of the clauses of the definition of “Permitted Liens” and such Lien securing such item of Indebtedness will be treated as being incurred or existing pursuant to only one of such clauses or pursuant to the first
paragraph of this Section 4.12. 
 SECTION 4.13 Payments for Consent. 

The Company will not, and will not permit any of its Subsidiaries to, directly or indirectly, pay or cause to be paid any consideration to or
for the benefit of any Holder of Notes for or as an inducement to any consent, waiver or amendment of any of the terms or provisions of this Indenture or the Notes unless such consideration is offered to be paid and is paid to all Holders of the
Notes that so consent, waive or agree to amend in the time frame set forth in the solicitation documents relating to such consent, waiver or agreement. 

SECTION 4.14 Offer to Purchase upon Change of Control. 

If a Change of Control occurs, unless the Company at such time has given notice of redemption under Section 3.7 with respect to
all outstanding Notes, each holder of Notes will have the right to require the Company to repurchase all or any part (equal to €100,000 or integral multiples of €1,000 in excess 

  
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thereof) of that Holder’s Notes pursuant to a Change of Control Offer on the terms set forth in this Indenture. In the Change of Control Offer, the Company will offer a payment (a
“Change of Control Payment”) in cash equal to 101% of the aggregate principal amount of Notes repurchased plus accrued and unpaid interest, if any, on the Notes repurchased, to the date of purchase. Within 30 days following any
Change of Control, unless the Company at such time has given notice of redemption under Section 3.7 with respect to all outstanding Notes, or, at the Company’s option, in advance of a Change of Control, the Company will
(i) mail a notice to each Holder, with a copy to the Trustee and each Agent, describing the transaction or transactions that constitute the Change of Control and offering to repurchase Notes on the date of such Change of Control Payment
specified in the notice, which date shall be no earlier than 30 days and no later than 60 days from the date such notice is mailed (the “Change of Control Payment Date”), pursuant to the procedures required by this Indenture and
described in such notice and (ii) if at the time of such notice the Notes are listed on the Irish Stock Exchange, or any other securities exchange, and admitted for trading on the Global Exchange Market of the Irish Stock Exchange, to the
extent the rules of the Irish Stock Exchange or such other securities exchange so require, cause a notice of the Change of Control Offer to be published in a leading newspaper of general circulation in Ireland (which is expected to be The Irish
Times) or, to the extent and in a manner permitted by such rules, post such notice on the official website of the Irish Stock Exchange (www.ise.ie) or through other methods permitted by such rules. The Company will comply with the
requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control. To
the extent that the provisions of any securities laws or regulations conflict with the Change of Control provisions of this Indenture, the Company will comply with the applicable securities laws and regulations and will not be deemed to have
breached its obligations under the Change of Control provisions of this Indenture by virtue of such conflict. 
 On the Change of Control
Payment Date, the Company will, to the extent lawful: 
 (1) accept for payment all Notes or portions of Notes properly
tendered pursuant to the Change of Control Offer; 
 (2) deposit with the Paying Agent an amount equal to the Change of
Control Payment in respect of all Notes or portions of Notes properly tendered; and 
 (3) deliver or cause to be delivered
to the Trustee the Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes or portions of Notes being purchased by the Company. 

The Paying Agent will promptly mail to each holder of Notes properly tendered the Change of Control Payment for such Notes, and the Trustee
will promptly authenticate and mail (or cause to be transferred by book entry) to each holder a new Note equal in principal amount to any unpurchased portion of the Notes surrendered, if any; provided that each new Note will be in a minimum
principal amount of €100,000 or integral multiples of €1,000 in excess thereof. 
 If at the time of any such Change of Control,
the Notes are listed on the Irish Stock Exchange or any other securities exchange, to the extent required by the Irish Stock Exchange or such other securities exchange, the Company will notify the Irish Stock Exchange or such other securities
exchange, as applicable, that a Change of Control has occurred and any relevant details relating to such Change of Control. 
 The Company
will not be required to make a Change of Control Offer upon a Change of Control if (i) a third party makes the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this Indenture
applicable to a Change of Control Offer made by 

  
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the Company and purchases all Notes properly tendered and not withdrawn under the Change of Control Offer, (ii) a notice of redemption has been given pursuant to Section 3.9 of
this Indenture unless and until there is a default in the payment of the applicable redemption price or (iii) if the Company’s obligations under this Indenture are defeased as described under Section 8.8 on or promptly
following the Change of Control. A Change of Control Offer may be made in advance of a Change of Control and may be conditional upon the occurrence of a Change of Control if a definitive agreement is in place for the Change of Control at the time
the Change of Control Offer is made. 
 The provisions described above that require the Company to make a Change of Control Offer following
a Change of Control, and the related provision of Section 3.9, will be applicable whether or not any other provisions of this Indenture are applicable. 

SECTION 4.15 Corporate Existence. 

Subject to Section 4.14 and Article V hereof, as the case may be, the Company shall do or cause to be done all things
necessary to preserve and keep in full force and effect its corporate existence and the corporate, partnership, limited liability company or other existence of each of its Subsidiaries in accordance with the respective organizational documents (as
the same may be amended from time to time) of the Company or any such Subsidiary and the rights (charter and statutory), licenses and franchises of the Company and its Subsidiaries; provided that the Company shall not be required to preserve
any such right, license or franchise, or the corporate, partnership or other existence of any of its Subsidiaries, if the Board of Directors of the Company shall determine that the preservation thereof is no longer desirable in the conduct of the
business of the Company and its Subsidiaries, taken as a whole, and that the loss thereof is not adverse in any material respect to the Holders. 

SECTION 4.16 Business Activities. 

The Company will not, and will not permit any Restricted Subsidiary to, engage in any business other than a Permitted Business, except to such
extent as would not be material to the Company and its Subsidiaries taken as a whole. 
 SECTION 4.17 Additional Guarantees. 

After the Issue Date, the Company will cause (i) each of its Domestic Subsidiaries (other than any Unrestricted Subsidiary) that incurs
any Indebtedness in excess of $35.0 million (other than Indebtedness permitted to be incurred pursuant to clauses (6), (7), (8), (9), (10), (11), (16) and (18) of the second paragraph of Section 4.9) and (ii) each
Restricted Subsidiary that guarantees any Indebtedness of the Company or any of the Guarantors, in each case, within ten (10) Business Days of such incurrence of any such Indebtedness or guarantee of such Indebtedness, to execute and deliver to
the Trustee a Guarantee pursuant to which such Restricted Subsidiary will unconditionally Guarantee, on a joint and several basis, the full and prompt payment of the principal of, premium, if any, and interest on the Notes and all other obligations
under this Indenture on the same terms and conditions as those set forth in this Indenture. 
 Each Guarantee will be limited to an amount
not to exceed the maximum amount that can be guaranteed by that Restricted Subsidiary without rendering the Guarantee, as it relates to such Restricted Subsidiary, voidable under applicable law relating to fraudulent conveyance or fraudulent
transfer or similar laws affecting the rights of creditors generally. 
 Each Guarantee shall automatically be released in accordance with
the provisions of this Indenture described under Article XI. 

  
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 SECTION 4.18 Maintenance of Listing. 

The Company will use its commercially reasonable efforts to obtain and maintain the listing of the Notes on the Irish Stock Exchange for so
long as the Notes are outstanding; provided that if the Company is unable to obtain admission to listing of the Notes on the Irish Stock Exchange or if at any time the Company determines that it will not maintain such listing, it will use its
commercially reasonable efforts to obtain and maintain a listing of the Notes on another recognised stock exchange. 
 SECTION 4.19
Further Instruments and Acts. 
 Upon request by the Trustee, the Company shall execute and deliver such further instruments and do
such further acts as may be reasonably necessary or proper to carry out more effectively the purposes of this Indenture. 
 SECTION 4.20
Fall Away Event. 
 In the event of the occurrence of a Fall Away Event (and notwithstanding any subsequent changes in the ratings of
the Notes or the occurrence of any Default), then, beginning on that day, the covenants under Section 4.7, 4.8, 4.9, 4.10, 4.11, 4.17 and 5.1(a)(4) (collectively, the “Terminated
Covenants”) shall each no longer be in effect for the remaining term of the Notes. 
 No Default, Event of Default or breach of any
kind will be deemed to exist under this Indenture or the Notes with respect to the Terminated Covenants based on, and none of the Company or any of its Subsidiaries will bear any liability for, any actions taken or events occurring after the Fall
Away Event, regardless of whether such actions or events would have been permitted if the applicable Terminated Covenants had remained in effect. 

ARTICLE V 
 SUCCESSORS 

SECTION 5.1 Merger, Consolidation or Sale of Assets. 

(a) The Company may not, directly or indirectly: (1) consolidate or merge with or into another Person (whether or not the Company is the
surviving corporation); or (2) sell, assign, transfer, convey, lease or otherwise dispose of all or substantially all of the properties or assets of the Company and its Restricted Subsidiaries, taken as a whole, in one or more related
transactions, to another Person; unless: 
 (1) (a) the Company is the surviving corporation; or (b) the Person formed
by or surviving any such consolidation or merger (if other than the Company) or to which such sale, assignment, transfer, conveyance, lease or other disposition has been made is a corporation or limited liability company organized or existing under
the laws of the United States, any state of the United States, the District of Columbia or any territory thereof (the Company or such Person, including the Person to which such sale, assignment, transfer, conveyance, lease or other disposition has
been made, as the case may be, being herein called the “Successor Company”); 
 (2) the Successor Company
(if other than the Company) assumes all the obligations of the Company under the Notes and this Indenture pursuant to agreements reasonably satisfactory to the Trustee; 

  
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 (3) immediately after such transaction, no Event of Default exists; 

(4) immediately after giving pro forma effect to such transaction and any related financing transactions, as if
the same had occurred at the beginning of the applicable four-quarter period, either (a) the Successor Company would be permitted to incur at least $1.00 of additional Indebtedness pursuant to the Fixed Charge Coverage Ratio test set forth in
the first paragraph of Section 4.9 or (b) the Fixed Charge Coverage Ratio for the Successor Company and its Restricted Subsidiaries would be at least equal to or greater than such ratio for the Company and its Restricted
Subsidiaries immediately prior to such transaction; and 
 (5) each Guarantor (except if it is the other party to the
transactions described above in which case clause (2) above shall apply) shall have by supplemental indenture confirmed that its Guarantee shall apply to such Person’s obligations under the Notes and the Indenture. 

(b) Notwithstanding the foregoing, clauses (4) and (5) above will not be applicable to (a) any Restricted Subsidiary
consolidating with, merging into or selling, assigning, transferring, conveying, leasing or otherwise disposing of all or part of its properties and assets to the Company or to another Guarantor; (b) the Company merging with an Affiliate solely
for the purpose of reincorporating the Company, as the case may be, in another jurisdiction; and (c) any Foreign Subsidiary may consolidate with or merge into or transfer all or part of its properties and assets to any other Foreign Subsidiary;
provided that if the Foreign Subsidiary so consolidating, merging or transferring all or part of its properties and assets is a Foreign Subsidiary that is a Guarantor, such Foreign Subsidiary shall, substantially simultaneously with such
merger, transfer or disposition, terminate its Guarantee and otherwise be in compliance with the terms of this Indenture. 
 (c) For
purposes of this Section 5.1, the sale, lease, conveyance, assignment, transfer or other disposition of all or substantially all of the properties and assets of one or more Restricted Subsidiaries of the Company, which properties and
assets, if held by the Company instead of such Restricted Subsidiaries, would constitute all or substantially all of the properties and assets of the Company on a consolidated basis, shall be deemed to be the sale, lease, conveyance, assignment,
transfer or other disposition of all or substantially all of the properties and assets of the Company. 
 (d) The predecessor company will
be released from its obligations under this Indenture and the Notes and the Successor Company will succeed to, and be substituted for, and may exercise every right and power of, the Company under this Indenture and the Notes, but, in the case of a
lease of all or substantially all its assets, the predecessor company will not be released from the obligation to pay the principal of and interest on the Notes. 

(e) In connection with any consolidation or merger or any sale, assignment, transfer, lease, conveyance or other disposition of all or
substantially all of the assets of the Company contemplated by this Section 5.1, the Company shall expressly assume the obligations under this Indenture and Notes by supplemental indenture and shall execute and deliver to the
Trustee a supplemental indenture, in form and substance reasonably satisfactory to the Trustee, evidencing such succession. 
 SECTION 5.2
Successor Corporation Substituted. 
 Upon any consolidation or merger, or any sale, assignment, transfer, lease, conveyance or other
disposition of all or substantially all of the assets of the Company in accordance with Section 5.1 hereof, the successor corporation formed by such consolidation or into or with which the Company is merged or to which such sale,
assignment, transfer, lease, conveyance or other disposition is made shall succeed to, and be substituted for (so that from and after the date of such consolidation, merger, sale, lease, 

  
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conveyance or other disposition, the provisions of this Indenture referring to the “Company” shall refer instead to the successor corporation and not to the Company), and shall exercise
every right and power of, the Company under this Indenture with the same effect as if such successor Person had been named as the Company herein. 

ARTICLE VI 
 DEFAULTS AND REMEDIES

 SECTION 6.1 Events of Default. 

Each of the following constitutes an “Event of Default”: 

(1) the Company defaults in payment when due and payable, upon redemption, acceleration or otherwise, of principal of, or
premium, if any, on the Notes; 
 (2) the Company defaults in the payment when due of interest on or with respect to the
Notes and such default continues for a period of 30 days; 
 (3) the Company defaults in the performance of, or breaches any
covenant, warranty or other agreement contained in, this Indenture (other than a default in the performance or breach of a covenant, warranty or agreement which is specifically dealt with in clauses (1) or (2) above) and such default or
breach continues for a period of 60 days after the notice specified below or 90 days if such default or breach is with respect to the covenant described under Section 4.3; 

(4) a default under any mortgage, indenture or instrument under which there is issued or by which there is secured or evidenced
any Indebtedness for money borrowed by the Company or any Restricted Subsidiary or the payment of which is guaranteed by the Company or any Restricted Subsidiary (other than Indebtedness owed to the Company or a Restricted Subsidiary), whether such
Indebtedness or guarantee now exists or is created after the Issue Date, if (A) such default either (1) results from the failure to pay any such Indebtedness at its stated final maturity (after giving effect to any applicable grace
periods) or (2) relates to an obligation other than the obligation to pay principal of any such Indebtedness at its stated final maturity and results in the holder or holders of such Indebtedness causing such Indebtedness to become due prior to
its stated maturity and (B) the principal amount of such Indebtedness, together with the principal amount of any other such Indebtedness in default for failure to pay principal at stated final maturity (after giving effect to any applicable
grace periods), or the maturity of which has been so accelerated, aggregate $65.0 million (or its foreign currency equivalent) or more at any one time outstanding; 

(5) the failure by the Company or any Significant Subsidiary to pay final judgments aggregating in excess of $65.0 million
(other than any judgments covered by indemnities or insurance policies as to which liability coverage has not been denied by the insurance company or indemnifying party), which final judgments remain unpaid, undischarged and unstayed for a period of
more than 60 days after the applicable judgment becomes final and non-appealable; 
 (6) the Guarantee of a Significant
Subsidiary that is a Guarantor or any group of Subsidiaries that are Guarantors and that, taken together as of the date of the most recent audited financial statements of the Company, would constitute a Significant Subsidiary ceases to be in full
force and effect (except as contemplated by the terms hereof) or any Guarantor denies or disaffirms its obligations under this Indenture or any Guarantee, other than by reason of the release of the Guarantee in accordance with the terms of this
Indenture; or 

  
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 (7) (i) the Company, any Restricted Subsidiary that is a Significant Subsidiary
or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary, pursuant to or within the meaning of any Bankruptcy Law: 

(a) commences a voluntary case, 

(b) consents to the entry of an order for relief against it in an involuntary case, 

(c) consents to the appointment of a custodian of it or for all or substantially all of its property, 

(d) makes a general assignment for the benefit of its creditors, or 

(e) generally is not paying its debts as they become due; 

(ii) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(a) is for relief against the Company or any Restricted Subsidiary that is a Significant Subsidiary or any group of Restricted
Subsidiaries that, taken together, would constitute a Significant Subsidiary, in an involuntary case; 
 (b) appoints a
custodian of the Company or any Restricted Subsidiary that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken together, would constitute a Significant Subsidiary or for all or substantially all of the property of the
Company or any of its Restricted Subsidiaries; or 
 (c) orders the liquidation of the Company or any Restricted Subsidiary
that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken together, would constitute a Significant Subsidiary and the order or decree remains unstayed and in effect for 60 consecutive days. 

SECTION 6.2 Acceleration. 

If an Event of Default (other than an Event of Default specified in clause (7) above with respect to the Company) shall occur and be
continuing, the Trustee acting at the written direction of the Holders or the Holders of at least 25% in aggregate principal amount of the outstanding Notes may declare the principal of the Notes and any accrued interest on the Notes to be due and
payable by notice in writing to the Company and the Trustee specifying the respective Event of Default and that it is a “notice of acceleration” (the “Acceleration Notice”), and the same shall become immediately due and
payable. 
 Upon such declaration of acceleration, the aggregate principal amount of, and accrued and unpaid interest, if any, on all of the
outstanding Notes shall ipso facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder of the Notes. After such acceleration, but before a judgment or decree based on
acceleration, the Holders of a majority in aggregate principal amount of such outstanding Notes may, under certain circumstances, rescind and annul such acceleration if all Events of Default, other than the nonpayment of accelerated principal of or
interest on such Notes, have been cured or waived as provided in this Indenture. 

  
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 The Holders of a majority in aggregate principal amount of the Notes then outstanding by written
notice to the Trustee may on behalf of the Holders of all of the Notes waive any existing Default or Event of Default and its consequences under this Indenture and its consequences: 

(1) if the rescission would not conflict with any judgment or decree; 

(2) if all existing Events of Default have been cured or waived except nonpayment of principal or interest that has become due
solely because of the acceleration; 
 (3) to the extent the payment of such interest is lawful, interest on overdue
installments of interest and overdue principal, which has become due otherwise than by such declaration of acceleration, has been paid; 

(4) if the Company has paid the Trustee its reasonable compensation and reimbursed the Trustee for its expenses, disbursements
and advances; and 
 (5) in the event of the cure or waiver of an Event of Default of the type described in clause (5)
of Section 6.1, the Trustee shall have received an Officers’ Certificate and an Opinion of Counsel that such Event of Default has been cured or waived. 

No such rescission shall affect any subsequent Default or impair any right consequent thereto. 

In the event of any Event of Default specified in clause (4) of Section 6.1, such Event of Default and all consequences
thereof (excluding, however, any resulting payment default) will be annulled, waived and rescinded, automatically and without any action by the Trustee or the Holders of the Notes, if within 30 days after such Event of Default arose the Company
delivers an Officers’ Certificate to the Trustee stating that (x) the Indebtedness or guarantee that is the basis for such Event of Default has been discharged, (y) the holders thereof have rescinded or waived the acceleration, notice
or action (as the case may be) giving rise to such Event of Default or (z) the default that is the basis for such Event of Default has been cured, it being understood that in no event shall an acceleration of the principal amount of the Notes
as described above be annulled, waived or rescinded upon the happening of any such events. 
 If an Event of Default specified in
clause (7) above with respect to the Company occurs and is continuing, then all unpaid principal of, and premium, if any, and accrued and unpaid interest, if any, on all of the outstanding Notes shall ipso facto become and be immediately
due and payable without any declaration or other act on the part of the Trustee or any holder of the Notes. 
 No Holder of any Note
will have any right to institute any proceeding with respect to this Indenture or for any remedy thereunder, unless such Holder shall have previously given to the Trustee written notice of a continuing Event of Default and unless also the Holders of
at least 25% in aggregate principal amount of the then outstanding Notes shall have made written request, and offered reasonable indemnity, to the Trustee to institute such proceeding as Trustee, and the Trustee shall not have received from the
Holders of a majority in aggregate principal amount of the outstanding Notes a direction inconsistent with such request and shall have failed to institute such proceeding within 60 days. Such limitations do not apply, however, to a suit
instituted by a Holder of a Note for enforcement of payment of the principal of (and premium, if any) or interest on such Note on or after the respective due dates expressed in such Note. 

In the case of any Event of Default occurring by reason of any willful action (or inaction) taken (or not taken) by or on behalf of the
Company with the intention of avoiding payment of the premium that the Company would have had to pay if the Company then had elected to redeem the Notes pursuant to Section 3.7, an equivalent premium shall also become and be immediately
due and payable to the extent permitted by law upon the acceleration of the Notes. 

  
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 SECTION 6.3 Other Remedies. 

If an Event of Default occurs and is continuing, the Trustee may pursue any available remedy to collect the payment of principal, premium, if
any, and interest on the Notes or to enforce the performance of any provision of the Notes or this Indenture. 
 The Trustee may maintain a
proceeding even if it does not possess any of the Notes or does not produce any of them in the proceeding. A delay or omission by the Trustee or any Holder in exercising any right or remedy accruing upon an Event of Default shall not impair the
right or remedy or constitute a waiver of or acquiescence in the Event of Default. All remedies are cumulative to the extent permitted by law. 

SECTION 6.4 Waiver of Past Defaults. 

The Holders of a majority in principal amount of the Notes issued and then outstanding under this Indenture by notice to the Trustee may on
behalf of the Holders of all of the Notes waive any existing Default or Event of Default under this Indenture, and its consequences, except a default in the payment of the principal of or interest on Notes (other than as a result of an
acceleration), which shall require the consent of all of the Holders of the Notes then outstanding. 
 SECTION 6.5 Control by
Majority. 
 The Holders of a majority in aggregate principal amount of the then outstanding Notes may direct the time, method and place
of conducting any proceeding for any remedy available to the Trustee or exercising any trust or power conferred on the Trustee. However, (i) the Trustee may refuse to follow any direction that conflicts with law or this Indenture, that the
Trustee determines may be unduly prejudicial to the rights of other Holders or that may involve the Trustee in personal liability, and (ii) the Trustee may take any other action deemed proper by the Trustee which is not inconsistent with such
direction. In case an Event of Default shall occur (which shall not be cured), the Trustee will be required, in the exercise of its power, to use the degree of care of a prudent man in the conduct of his own affairs. Notwithstanding any provision to
the contrary in this Indenture, the Trustee is under no obligation to exercise any of its rights or powers under this Indenture at the request, order or direction of any Holder, unless such Holder shall offer to the Trustee security and indemnity
satisfactory to it against any loss, liability or expense. 
 SECTION 6.6 Limitation on Suits. 

A Holder may pursue a remedy with respect to this Indenture or the Notes only if: 

(a) the Holder gives to the Trustee written notice of a continuing Event of Default or the Trustee receives such notice from
the Company; 
 (b) the Holders of at least 25% in aggregate principal amount of the then outstanding Notes make a written
request to the Trustee to pursue the remedy; 
 (c) such Holder or Holders offer and, if requested, provide to the Trustee
indemnity or security reasonably satisfactory to the Trustee against any loss, liability or expense; 

  
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 (d) the Trustee does not comply with the request within 60 days after
receipt of the request and the offer and, if requested, the provision of such indemnity or security; and 
 (e) during such 60-day period the Holders of a majority in aggregate principal amount of the then outstanding Notes do not give the Trustee a direction inconsistent with the request. 

A Holder may not use this Indenture to prejudice the rights of another Holder or to obtain a preference or priority over another Holder. 

SECTION 6.7 Rights of Holders of Notes to Receive Payment. 

Notwithstanding any other provision of this Indenture, the right of any Holder to receive payment of principal, premium, if any, and interest
on or after the respective due dates expressed in the Note (including in connection with an offer to purchase), or to bring suit for the enforcement of any such payment on or after such respective dates, shall not be impaired or affected without the
consent of such Holder. 
 SECTION 6.8 Collection Suit by Trustee. 

If an Event of Default specified in Section 6.1(1) or (2) hereof occurs and is continuing, the Trustee is authorized
to recover judgment in its own name and as trustee of an express trust against the Company for the whole amount of principal of, premium and interest remaining unpaid on the Notes and interest on overdue principal and, to the extent lawful, interest
and such further amount as shall be sufficient to cover the costs and expenses of collection, including the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel. 

SECTION 6.9 Trustee May File Proofs of Claim. 

The Trustee is authorized to file such proofs of claim and other papers or documents as may be necessary or advisable in order to have the
claims of the Trustee (including any claim for the reasonable compensation, expenses, disbursements and advances of the Trustee, its agents and counsel), the Agents and the Holders allowed in any judicial proceedings relative to the Company (or any
other obligor upon the Notes), its creditors or its property and shall be entitled and empowered to collect, receive and distribute any money or other securities or property payable or deliverable upon the conversion or exchange of the Notes or on
any such claims and any custodian in any such judicial proceeding is hereby authorized by each Holder to make such payments to the Trustee, and in the event that the Trustee shall consent to the making of such payments directly to the Holders, to
pay to the Trustee and the Agents any amount due to them for the reasonable compensation, expenses, disbursements and advances of the Trustee, the Agents, their agents and counsel, and any other amounts due the Trustee and the Agents under
Section 7.7 hereof. To the extent that the payment of any such compensation, expenses, disbursements and advances of the Trustee, the Agents, their agents and counsel, and any other amounts due the Trustee and the Agents under
Section 7.7 hereof out of the estate in any such proceeding, shall be denied for any reason, payment of the same shall be secured by a Lien on, and shall be paid out of, any and all distributions, dividends, money, securities and other
properties that the Holders may be entitled to receive in such proceeding whether in liquidation or under any plan of reorganization or arrangement or otherwise. Nothing herein contained shall be deemed to authorize the Trustee to authorize or
consent to or accept or adopt on behalf of any Holder any plan of reorganization, arrangement, adjustment or composition affecting the Notes or the rights of any Holder, or to authorize the Trustee to vote in respect of the claim of any Holder in
any such proceeding. 

  
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 SECTION 6.10 Priorities. 

If the Trustee collects any money or property pursuant to this Article VI, it shall pay out the money and property in the following
order: 
 First: to the Trustee, the Agent, their agents and attorneys for amounts due under Section 7.7 hereof,
including payment of all reasonable compensation, expense and liabilities incurred, and all advances made, by the Trustee and the Agents and the costs and expenses of collection; 

Second: to Holders of Notes for amounts due and unpaid on the Notes for principal, premium, if any, and interest ratably,
without preference or priority of any kind, according to the amounts due and payable on the Notes for principal, premium, if any, and interest, respectively; 

Third: without duplication, to the Holders for any other Obligations owing to the Holders under this Indenture and the Notes;
and 
 Fourth: to the Company or to such party as a court of competent jurisdiction shall direct. 

The Trustee may fix a record date and payment date for any payment to Holders pursuant to this Section 6.10. 

SECTION 6.11 Undertaking for Costs. 

In any suit for the enforcement of any right or remedy under this Indenture or in any suit against the Trustee for any action taken or omitted
by it as a Trustee, a court in its discretion may require the filing by any party litigant in the suit of an undertaking to pay the costs of the suit, and the court in its discretion may assess reasonable costs, including reasonable attorneys’
fees and expenses, against any party litigant in the suit, having due regard to the merits and good faith of the claims or defenses made by the party litigant. This Section 6.11 does not apply to a suit by the Trustee, a suit by a Holder
pursuant to Section 6.7 hereof, or a suit by Holders of more than 10% in principal amount of the then outstanding Notes. 

ARTICLE VII 
 TRUSTEE 

SECTION 7.1 Duties of Trustee. 

(a) If an Event of Default has occurred and is continuing, the Trustee shall exercise such of the rights and powers vested in it by this
Indenture and use the same degree of care and skill in its exercise, as a prudent person would exercise or use under the circumstances in the conduct of such person’s affairs. 

(b) Except during the continuance of an Event of Default: 

(i) the duties of the Trustee shall be determined solely by the express provisions of this Indenture and the Trustee need
perform only those duties that are specifically set forth in this Indenture and no others, and no implied covenants or obligations shall be read into this Indenture against the Trustee; and 

(ii) in the absence of bad faith on its part, the Trustee may conclusively rely, as to the truth of the statements and the
correctness of the opinions expressed therein, upon certificates or opinions furnished to the Trustee and conforming to the requirements of this Indenture (but need not confirm or investigate the accuracy of mathematical calculations or other facts
stated therein). 

  
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 However, the Trustee shall examine the certificates and opinions furnished to it to determine whether or not they
conform to the requirements of this Indenture. 
 (c) The Trustee may not be relieved from liabilities for its own negligent action, its own
negligent failure to act, or its own willful misconduct, except that: 
 (i) this paragraph does not limit the effect of
paragraph (b) of this Section 7.1; 
 (ii) the Trustee shall not be liable for any error of judgment made in
good faith by a Responsible Officer, unless it is proved that the Trustee was negligent in ascertaining the pertinent facts; and 

(iii) the Trustee shall not be liable with respect to any action it takes or omits to take in good faith in accordance with a
direction received by it pursuant to Section 6.5 hereof. 
 (d) Whether or not therein expressly so provided, every provision of
this Indenture that in any way relates to the Trustee is subject to paragraphs (a), (b) and (c) of this Section 7.1. 

(e) No provision of this Indenture shall require the Trustee to expend or risk its own funds or incur any liability. The Trustee shall be
under no obligation to exercise any of its rights and powers under this Indenture at the request of any Holders, unless such Holder shall have offered to the Trustee security and indemnity satisfactory to it against any loss, liability or expense.

 (f) The Trustee shall not be liable for interest on any money received by it except as the Trustee may agree in writing with the Company.
Money held in trust by the Trustee need not be segregated from other funds except to the extent required by law. 
 SECTION 7.2 Rights of
Trustee. 
 (a) The Trustee may conclusively rely and shall be fully protected in acting or refraining from acting on any document
(whether in original or facsimile form) believed by it to be genuine and to have been signed or presented by the proper Person. The Trustee need not investigate any fact or matter stated in the document. 

(b) Before the Trustee acts or refrains from acting, it may require an Officers’ Certificate or an Opinion of Counsel or both. The
Trustee shall not be liable for any action it takes or omits to take in good faith in reliance on such Officers’ Certificate or Opinion of Counsel. Prior to taking, suffering or admitting any action, the Trustee may consult with counsel of the
Trustee’s own choosing and the Trustee shall be fully protected from liability in respect of any action taken, suffered or omitted by it hereunder in good faith and in conclusive reliance on the advice or opinion of such counsel. 

(c) The Trustee may act through its attorneys and agents and shall not be responsible for the misconduct or negligence of any attorney or
agent appointed with due care. 
 (d) The Trustee shall not be liable for any action it takes or omits to take in good faith that it
believes to be authorized or within the rights or powers conferred upon it by this Indenture. Any request 

  
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or direction of the Company mentioned herein shall be sufficiently evidenced by an Officers’ Certificate and any resolution of the Board of Directors may be sufficiently evidenced by a Board
Resolution. Whenever in the administration of this Indenture the Trustee shall deem it desirable that a matter be proved or established prior to taking, suffering or omitting any action hereunder, the Trustee (unless other evidence be herein
specifically prescribed) may, in the absence of bad faith on its part, conclusively rely upon an Officers’ Certificate. 
 (e) Unless
otherwise specifically provided in this Indenture, any demand, request, direction or notice from the Company shall be sufficient if signed by an Officer of the Company. 

(f) The Trustee shall be under no obligation to exercise any of the rights or powers vested in it by this Indenture at the request or
direction of any of the Holders unless such Holders shall have offered to the Trustee reasonable security or indemnity satisfactory to the Trustee against the costs, expenses and liabilities that might be incurred by it in compliance with such
request or direction. 
 (g) The Trustee shall not be bound to make any investigation into the facts or matters stated in any resolution,
certificate, statement, instrument, opinion, report, notice, request, direction, consent, order, bond, debenture, note, other evidence of indebtedness or other paper or documents, but the Trustee, in its discretion, may make such further inquiry or
investigation into such facts or matters as it may see fit, and, if the Trustee shall determine to make such further inquiry or investigation, it shall be entitled to examine during normal business hours the books, records and premises of the
Company, personally or by agent or attorney at the sole cost of the Company, and shall incur no liability or additional liability of any kind by reason of such inquiry or investigation. 

(h) The rights, privileges, protections and benefits given to the Trustee, including, without limitation, its rights to compensation and to be
indemnified, are extended to, and shall be enforceable by, the Trustee in each of its capacities hereunder, the Paying Agent and the Registrar, and to each other agent, custodian and other Persons employed to act hereunder. 

(i) The Trustee may request that the Company deliver an Officers’ Certificate setting forth the names of individuals and/or titles of
officers authorized at such time to take specified actions pursuant to this Indenture, which Officers’ Certificate may be signed by any person authorized to sign an Officers’ Certificate, including any person specified as so authorized in
any such certificate previously delivered and not superseded. 
 (j) The Trustee shall not be deemed to have notice or be charged with
knowledge of any Default or Event of Default unless the Trustee shall have received from the Company or any other obligor upon the Notes or from any Holder written notice thereof at its address set forth in Section 12.2 hereof, and such
notice references the Notes and this Indenture. In the absence of any such notice, the Trustee may conclusively assume that no such Default or Event of Default exists. 

SECTION 7.3 Individual Rights of Trustee. 

The Trustee in its individual or any other capacity may become the owner or pledgee of Notes and may otherwise deal with the Company or any
Affiliate of the Company with the same rights it would have if it were not Trustee. However, in the event that the Trustee acquires any conflicting interest it must eliminate such conflict within 90 days, apply to the Commission for permission
to continue as Trustee or resign. Any Agent may do the same with like rights and duties. The Trustee is also subject to Sections 7.10 hereof. 

  
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 SECTION 7.4 Trustee’s Disclaimer. 

The Trustee shall not be responsible for and makes no representation as to the validity or adequacy of this Indenture or the Notes or the
Offering Circular, it shall not be accountable for the Company’s use of the proceeds from the Notes or any money paid to the Company or upon the Company’s direction under any provision of this Indenture, it shall not be responsible for the
use or application of any money received by any Paying Agent other than the Trustee, and it shall not be responsible for any statement or recital herein or any statement in the Notes or the Offering Circular, any statement or recital on any
Officers’ Certificate delivered to the Trustee under Article IV or Section 8.4 hereof, or any other document in connection with the sale of the Notes or pursuant to this Indenture other than its certificate of
authentication. 
 SECTION 7.5 Notice of Defaults. 

If a Default or Event of Default occurs and is continuing and if it is actually known to a Responsible Officer, the Trustee shall mail to
Holders a notice of the Default or Event of Default within 90 days after it occurs. Except in the case of a Default or Event of Default in payment of principal of, premium, if any, or interest on any Note, the Trustee may withhold the notice if
and so long as the board of directors, the executive committee or a trust committee of directors or Responsible Officers of the Trustee in good faith determines that withholding the notice is in the interests of the Holders. 

SECTION 7.6 [Reserved]. 

SECTION 7.7 Compensation and Indemnity. 

The Company shall pay to the Trustee from time to time compensation for its acceptance of this Indenture and services hereunder as agreed upon
in writing. The Trustee’s compensation shall not be limited by any law on compensation of a trustee of an express trust. The Company shall reimburse the Trustee promptly upon request for all reasonable disbursements, advances and expenses
incurred or made by it in addition to the compensation for its services. Such expenses shall include the reasonable compensation, disbursements and expenses of the Trustee’s agents and counsel. 

The Company and the Guarantors, jointly and severally, shall indemnify the Trustee (which for purposes of this Section 7.7 shall
include its officers, directors, employees and agents) against any and all claims, damage, losses, liabilities or expenses incurred by it arising out of or in connection with the acceptance or administration of its duties under this Indenture,
including the costs and expenses of enforcing this Indenture against the Company (including this Section 7.7) and defending itself against any claim (whether asserted by the Company or any Holder or any other Person) or liability in
connection with the exercise or performance of any of its powers or duties hereunder except to the extent any such loss, claim, damage, liability or expense may be attributable to its negligence or bad faith. The Trustee shall notify the Company
promptly of any claim for which it may seek indemnity. Failure by the Trustee to so notify the Company shall not relieve the Company of its obligations hereunder. The Company shall defend the claim and the Trustee shall cooperate in the defense. The
Trustee may have separate counsel and the Company shall pay the reasonable fees and expenses of one such counsel. The Company need not pay for any settlement made without its consent, which consent shall not be unreasonably withheld. Under no
circumstances shall the Trustee be liable for any consequential or punitive damages of any kind. 
 The obligations of the Company and the
Guarantors under this Section 7.7 shall survive the satisfaction and discharge of this Indenture or the resignation or removal of the Trustee, including any termination under any Bankruptcy Law. 

  
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 To secure the Company’s payment obligations in this Section 7.7, the Trustee
shall have a Lien prior to the Notes on all money or property held or collected by the Trustee, except that held in trust to pay principal or interest, if any, on particular Notes. Such Lien shall survive the satisfaction and discharge of this
Indenture and the resignation or removal of the Trustee, including any termination under any Bankruptcy Law. 
 When the Trustee incurs
expenses or renders services after an Event of Default specified in Section 6.1(7) hereof occurs, the expenses and the compensation for the services (including the fees and expenses of its agents and counsel) are intended to constitute
expenses of administration under any Bankruptcy Law. 
 SECTION 7.8 Replacement of Trustee. 

A resignation or removal of the Trustee and appointment of a successor Trustee shall become effective only upon the successor Trustee’s
acceptance of appointment as provided in this Section 7.8. 
 The Trustee may resign in writing at any time and be discharged
from the trust hereby created by so notifying the Company. The Holders of a majority in principal amount of the then outstanding Notes may remove the Trustee by so notifying the Trustee and the Company in writing. The Company may remove the Trustee
if: 
 (a) the Trustee fails to comply with Section 7.10 hereof; 

(b) the Trustee is adjudged a bankrupt or an insolvent or an order for relief is entered with respect to the Trustee under any
Bankruptcy Law; 
 (c) a custodian or public officer takes charge of the Trustee or its property; or 

(d) the Trustee becomes incapable of acting. 

If the Trustee resigns or is removed or if a vacancy exists in the office of Trustee for any reason, the Company shall promptly appoint a
successor Trustee. Within one year after the successor Trustee takes office, the Holders of a majority in principal amount of the then outstanding Notes may appoint a successor Trustee to replace the successor Trustee appointed by the Company. 

If a successor Trustee does not take office within 60 days after the retiring Trustee resigns or is removed, the retiring Trustee, the
Company or the Holders of at least 10% in principal amount of the then outstanding Notes may, at the expense of the Company, petition any court of competent jurisdiction for the appointment of a successor Trustee. 

If the Trustee, after written request by any Holder who has been a Holder for at least six months, fails to comply with
Section 7.10 hereof, such Holder may, at the expense of the Company, petition any court of competent jurisdiction for the removal of the Trustee and the appointment of a successor Trustee. 

A successor Trustee shall deliver a written acceptance of its appointment to the retiring Trustee and to the Company. Thereupon, the
resignation or removal of the retiring Trustee shall become effective, and the successor Trustee shall have all the rights, powers and the duties of the Trustee under this Indenture. The successor Trustee shall mail a notice of its succession to the
Holders. The retiring Trustee shall promptly transfer all property held by it as Trustee to the successor Trustee, provided that all sums owing to the Trustee hereunder have been paid and subject to the Lien provided for in
Section 7.7 hereof. Notwithstanding replacement of the Trustee pursuant to this Section 7.8, the Company’s and the Guarantors’ obligations under Section 7.7 hereof shall continue for the benefit of the
retiring Trustee. 

  
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 SECTION 7.9 Successor Trustee by Merger, Etc. 

If the Trustee consolidates, merges or converts into, or transfers all or substantially all of its corporate trust business (including the
administration of this Indenture) to, another corporation, the successor corporation without any further act shall be the successor Trustee. 

SECTION 7.10 Eligibility; Disqualification. 

There shall at all times be a Trustee hereunder that is a corporation organized and doing business under the laws of the United States of
America or of any state thereof that is authorized under such laws to exercise corporate trustee power and that is subject to supervision or examination by federal or state authorities. The Trustee together with its affiliates shall at all times
have a combined capital surplus of at least $50.0 million as set forth in its most recent published annual report of condition. 
 This
Indenture shall always have a Trustee who satisfies the requirements of TIA §§ 310(a)(5). 
 SECTION 7.11 [Reserved].

 SECTION 7.12 Trustee’s Application for Instructions from the Company. 

Any application by the Trustee for written instructions from the Company may, at the option of the Trustee, set forth in writing any action
proposed to be taken or omitted by the Trustee under this Indenture and the date on and/or after which such action shall be taken or such omission shall be effective. The Trustee shall not be liable for any action taken by, or omission of, the
Trustee in accordance with a proposal included in such application on or after the date specified in such application (which date shall not be less than 20 Business Days after the date any officer of the Company actually receives such application,
unless any such officer shall have consented in writing to any earlier date) unless prior to taking any such action (or the effective date in the case of an omission), the Trustee shall have received written instructions in response to such
application specifying the action to be taken or omitted. 
 ARTICLE VIII 

DEFEASANCE; DISCHARGE OF THE INDENTURE 

SECTION 8.1 Option to Effect Legal Defeasance or Covenant Defeasance. 

The Company may, at the option of its Board of Directors and evidenced by a Board Resolution set forth in an Officers’ Certificate, at
any time, elect to have either Section 8.2 or 8.3 hereof applied to all outstanding Notes upon compliance with the conditions set forth below in this Article VIII. 

SECTION 8.2 Legal Defeasance. 

Upon the Company’s exercise under Section 8.1 hereof of the option applicable to this Section 8.2, The Company
shall, subject to the satisfaction of the conditions set forth in Section 8.4 hereof, be deemed to have been discharged from its obligations with respect to all outstanding Notes on the date the conditions set forth below are satisfied
(hereinafter, “Legal Defeasance”) except for (i) the rights of Holders of outstanding Notes to receive payments in respect of the principal of, premium, if any, and interest on, such Notes when such payments are due from the
trust referred to below, (ii) the Company’s 

  
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obligations with respect to the Notes concerning issuing temporary Notes, registration of Notes, mutilated, destroyed, lost or stolen Notes and the maintenance of an office or agency for payment
and money for security payments held in trust, (iii) the rights, powers, trusts, duties and immunities of the Trustee, and the Company’s obligations in connection therewith and (iv) the Legal Defeasance provisions of this Indenture.
For this purpose, Legal Defeasance means that the Company shall be deemed to have paid and discharged the entire Indebtedness represented by the outstanding Notes, which shall thereafter be deemed to be “outstanding” only for the purposes
of Section 8.5 hereof and the other Sections of this Indenture referred to in (a) and (b) below, and to have satisfied all of its other obligations under such Notes and this Indenture (and the Trustee, on demand of and at the
expense of the Company, shall execute proper instruments acknowledging the same), except for the following provisions which shall survive until otherwise terminated or discharged hereunder: (a) the rights of Holders of outstanding Notes to
receive payments in respect of the principal of, premium, if any, and interest, if any, on such Notes when such payments are due from the trust referred to in Section 8.4(1); (b) the Company’s obligations with respect to such
Notes under Sections 2.2, 2.3, 2.4, 2.5, 2.6, 2.7, 2.10 and 4.2 hereof; (c) the rights, powers, trusts, duties and immunities of the Trustee, including without limitation thereunder,
under Sections 7.7, 8.5 and 8.7 hereof and the Company’s obligations in connection therewith; (d) the Company’s rights pursuant to Section 3.7; and (e) the provisions of this
Article VIII. Subject to compliance with this Article VIII, the Company may exercise its option under this Section 8.2 notwithstanding the prior exercise of its option under Section 8.3 hereof. 

SECTION 8.3 Covenant Defeasance. 

Upon the Company’s exercise under Section 8.1 hereof of the option applicable to this Section 8.3, the Company
shall, subject to the satisfaction of the conditions set forth in Section 8.4 hereof, be released from its obligations under the covenants contained in Sections 4.3, 4.7, 4.8, 4.9, 4.10, 4.11,
4.12, 4.13, 4.14, 4.15, 4.16, 4.17, 4.18, and 5.1 hereof and the operation of Sections 6.1(3), 6.1(4) and 6.1(5) with respect to the outstanding Notes on and after the date
the conditions set forth below are satisfied (hereinafter, “Covenant Defeasance”), and the Notes shall thereafter be deemed not “outstanding” for the purposes of any direction, waiver, consent or declaration or act of
Holders (and the consequences of any thereof) in connection with such covenants, but shall continue to be deemed “outstanding” for all other purposes hereunder (it being understood that such Notes shall not be deemed outstanding for
accounting purposes). For this purpose, Covenant Defeasance means that, with respect to the outstanding Notes, the Company or any of its Subsidiaries may omit to comply with and shall have no liability in respect of any term, condition or limitation
set forth in any such covenant, whether directly or indirectly, by reason of any reference elsewhere herein to any such covenant or by reason of any reference in any such covenant to any other provision herein or in any other document and such
omission to comply shall not constitute a Default or an Event of Default under Section 6.1 hereof, but, except as specified above, the remainder of this Indenture and such Notes shall be unaffected thereby. In addition, upon the
Company’s exercise under Section 8.1 hereof of the option applicable to this Section 8.3, subject to the satisfaction of the conditions set forth in Section 8.4 hereof, Sections 6.1(4),
(5), (6) and (7) hereof shall not constitute Events of Default. 
 Notwithstanding any discharge or release
of any obligations pursuant to Section 8.2 or 8.3, the Company’s obligations in Sections 2.5, 2.6, 2.7, 2.8, 7.7, 8.6 and 8.7 shall survive until the Notes are no longer
outstanding pursuant to the last paragraph of Section 2.8. After the Notes are no longer outstanding, the Company’s obligations in Sections 7.7, 8.6 and 8.7 shall survive. 

  
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 SECTION 8.4 Conditions to Legal or Covenant Defeasance. 

The following shall be the conditions to the application of either Section 8.2 or 8.3 hereof to the outstanding Notes: 

(1) the Company must irrevocably deposit with the Trustee, in trust, for the benefit of the Holders of the Notes issued
hereunder, cash in euros, non-callable Government Securities, or a combination of cash in euros and non-callable Government Securities, in amounts as will be sufficient, in the opinion of a nationally recognized investment bank, appraisal firm or
firm of independent public accountants, to pay the principal of, or interest and premium, if any, on the outstanding Notes issued hereunder on the Stated Maturity or on the applicable redemption date, as the case may be, and the Company must specify
whether the Notes are being defeased to maturity or to a particular redemption date; 
 (2) in the case of Legal Defeasance,
the Company shall have delivered to the Trustee an Opinion of Counsel reasonably acceptable to the Trustee confirming that (a) the Company has received from, or there has been published by, the Internal Revenue Service a ruling or
(b) since the date of this Indenture, there has been a change in the applicable federal income tax law, in either case to the effect that, and based thereon such Opinion of Counsel will confirm that, the holders of the outstanding Notes will
not recognize income, gain or loss for federal income tax purposes as a result of such Legal Defeasance and will be subject to federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such Legal
Defeasance had not occurred; 
 (3) in the case of Covenant Defeasance, the Company shall have delivered to the Trustee an
Opinion of Counsel reasonably acceptable to the Trustee confirming that the holders of the outstanding Notes will not recognize income, gain or loss for federal income tax purposes as a result of such Covenant Defeasance and will be subject to
federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such Covenant Defeasance had not occurred; 

(4) no Event of Default shall have occurred and be continuing on the date of such deposit (other than an Event of Default
resulting from the borrowing of funds to be applied to such deposit and the grant of any Lien securing such borrowings); 

(5) such Legal Defeasance or Covenant Defeasance will not result in a breach or violation of, or constitute a default under any
material agreement or instrument (other than this Indenture) to which the Company or any Guarantor are a party or by which the Company or any Guarantor is bound; 

(6) the Company shall deliver to the Trustee an Officers’ Certificate stating that the deposit was not made by the Company
with the intent of preferring the Holders of Notes over the other creditors of the Company or any Guarantor or with the intent of defeating, hindering, delaying or defrauding creditors of the Company or any Guarantor or others; and 

(7) the Company shall deliver to the Trustee an Officers’ Certificate and an Opinion of Counsel (which may be subject to
certain limitations), each stating that all conditions precedent provided for or relating to the Legal Defeasance or the Covenant Defeasance have been complied with. 

  
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 Notwithstanding the foregoing, the requirements of clause (2) above with respect to a Legal
Defeasance or clause (3) above with respect to a Covenant Defeasance need not be complied with if all Notes not theretofore delivered to the Trustee for cancellation (x) have become due and payable or (y) will become due and payable
on the maturity date within one year under arrangements satisfactory to the Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company. 

SECTION 8.5 Deposited Money and Government Securities to Be Held in Trust; Other Miscellaneous Provisions. 

Subject to Section 8.6 hereof, all money and non-callable Government Securities (including the proceeds thereof) deposited with
the Trustee (or other qualifying trustee, collectively for purposes of this Section 8.5, the “Trustee”) pursuant to Section 8.4 hereof in respect of the outstanding Notes shall be held in trust, shall not be
invested, and applied by the Trustee, in accordance with the provisions of such Notes and this Indenture, to the payment, either directly or through any Paying Agent (including the Company or any Subsidiary acting as Paying Agent) as the Trustee may
determine, to the Holders of such Notes of all sums due and to become due thereon in respect of principal, premium, if any, and interest but such money need not be segregated from other funds except to the extent required by law. 

The Company shall pay and indemnify the Trustee against any tax, fee or other charge imposed on or assessed against the cash or non-callable
Government Securities deposited pursuant to Section 8.4 hereof or the principal and interest received in respect thereof other than any such tax, fee or other charge which by law is for the account of the Holders of the outstanding
Notes. 
 Anything in this Article VIII to the contrary notwithstanding, the Trustee shall deliver or pay to the Company from time to
time upon the written request of the Company and be relieved of all liability with respect to any money or non-callable Government Securities held by it as provided in Section 8.4 hereof which, in the opinion of a nationally recognized
firm of independent public accountants expressed in a written certification thereof delivered to the Trustee (which may be the opinion delivered under Section 8.4(a) hereof), are in excess of the amount thereof that would then be
required to be deposited to effect an equivalent Legal Defeasance or Covenant Defeasance. 
 SECTION 8.6 Repayment to Company. 

Any money deposited with the Trustee or any Paying Agent, or then held by the Company, in trust for the payment of the principal of, premium,
if any, or interest on any Note and remaining unclaimed for one year after such principal and premium, if any, or interest has become due and payable shall be paid to the Company on its written request or (if then held by the Company) shall be
discharged from such trust; and the Holder of such Note shall thereafter, as an unsecured general creditor, look only to the Company for payment thereof, and all liability of the Trustee or such Paying Agent with respect to such trust money, and all
liability of the Company as trustee thereof, shall thereupon cease; provided, however, that the Trustee or such Paying Agent, before being required to make any such repayment, may at the expense of the Company cause to be published once, in
The New York Times and The Wall Street Journal (national edition), notice that such money remains unclaimed and that, after a date specified therein, which shall not be less than 30 days from the date of such notification or
publication, any unclaimed balance of such money then remaining shall be repaid to the Company. 
 SECTION 8.7 Reinstatement. 

If the Trustee or Paying Agent is unable to apply any euros or non-callable Government Securities in accordance with Section 8.2,
8.3 or 8.8 hereof, as the case may be, by reason of any order or judgment 

  
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of any court or governmental authority enjoining, restraining or otherwise prohibiting such application, then the obligations of the Company under this Indenture and the Notes shall be revived
and reinstated as though no deposit had occurred pursuant to Section 8.2, 8.3 or 8.8 hereof until such time as the Trustee or Paying Agent is permitted to apply all such money in accordance with Section 8.2,
8.3 or 8.8 hereof, as the case may be; provided, however, that, if the Company makes any payment of principal of, premium, if any, or interest on any Note following the reinstatement of its obligations, the Company shall
be subrogated to the rights of the Holders of such Notes to receive such payment from the money held by the Trustee or Paying Agent. 

SECTION 8.8 Discharge. 

The Company and the Guarantors may terminate the obligations under this Indenture and the Notes when: 

(1) either: 

(a) all Notes that have been authenticated, except lost, stolen or destroyed Notes that have been replaced or paid and Notes
for whose payment money has been deposited in trust and thereafter repaid to the Company, have been delivered to the Trustee for cancellation; or 

(b) all Notes that have not been delivered to the Trustee for cancellation have become due and payable by reason of the mailing
of a notice of redemption or otherwise or will become due and payable by reason of the mailing of a notice of redemption or otherwise within one year and the Company has irrevocably deposited or caused to be deposited with the Trustee as trust funds
in trust solely for the benefit of the Holders of the Notes, cash in euros, non-callable Government Securities, or a combination thereof, in amounts as will be sufficient without consideration of any reinvestment of interest, to pay and discharge
the entire Indebtedness on the Notes not delivered to the Trustee for cancellation for principal, premium and accrued interest to the date of maturity or redemption; 

(2) no Event of Default shall have occurred and be continuing on the date of the deposit or will occur as a result of the
deposit (other than a Default resulting from borrowing of funds to be applied to such deposit and the grant of any Lien securing such borrowing) and the deposit will not result in a breach or violation of, or constitute a default under, any other
material instrument to which the Company is a party or by which the Company is bound; 
 (3) the Company shall have paid or
caused to be paid all sums payable by it under this Indenture; 
 (4) the Company shall have delivered irrevocable
instructions to the Trustee under this Indenture to apply the deposited money toward the payment of the Notes issued thereunder at maturity or the redemption date, as the case may be; and 

(5) the Company shall have delivered an Officers’ Certificate and an Opinion of Counsel (which may be subject to certain
qualifications) to the Trustee stating that all conditions precedent to satisfaction and discharge have been satisfied. 
 In the case of
clause (1)(b) of this Section 8.8, and subject to the next sentence and notwithstanding the foregoing paragraph, the Company’s obligations in Sections 2.5, 2.6, 2.7, 2.8, 4.1, 4.2,
4.15 (as to 

  
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legal existence of the Company only), 7.7, 8.6 and 8.7 shall survive until the Notes are no longer outstanding pursuant to the last paragraph of Section 2.8.
After the Notes are no longer outstanding, the Company’s obligations in Sections 7.7, 8.6 and 8.7 shall survive any discharge pursuant to Section 8.8. 

After such delivery or irrevocable deposit, the Trustee upon request shall acknowledge in writing the discharge of the Company’s
obligations under the Notes and this Indenture except for those surviving obligations specified above. 
 In connection with a discharge, in
the event the Company becomes insolvent within the applicable preference period after the date of deposit, monies held for the payment of the Notes may be part of the bankruptcy estate of the Company, disbursement of such monies may be subject to
the automatic stay of the Bankruptcy Law and monies disbursed to Holders may be subject to disgorgement in favor of the Company’s estate. 

ARTICLE IX 
 AMENDMENT, SUPPLEMENT
AND WAIVER 
 SECTION 9.1 Without Consent of Holders of the Notes. 

Notwithstanding Section 9.2, without the consent of any Holders, the Company, the Guarantors, if any, and the Trustee, at any time
and from time to time, may amend or supplement this Indenture, the Notes or the Guarantees for any of the following purposes: 

(1) to cure any ambiguity, mistake, defect or inconsistency; 

(2) to provide for uncertificated Notes in addition to or in place of certificated Notes; 

(3) to provide for the assumption by a Successor Company or a successor company of a Guarantor, as applicable, of the
Company’s or such Guarantor’s obligations under this Indenture, the Notes or any Guarantee; 
 (4) to make any
change that would provide any additional rights or benefits to the Holders of Notes or that does not adversely affect the legal rights under this Indenture of any such Holder; 

(5) to secure the Notes; 

(6) [reserved]; 

(7) to add a Guarantee of the Notes; 

(8) to release a Guarantor upon its sale or designation as an Unrestricted Subsidiary or other permitted release from
its Guarantee; provided that such sale, designation or release is in accordance with the applicable provisions of this Indenture; or 

(9) to conform the text of this Indenture, Notes or Guarantees to any provision of the “Description of Notes” in the
Offering Circular. 

  
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 SECTION 9.2 With Consent of Holders of Notes. 

With the consent of the Holders of not less than a majority in aggregate principal amount of the outstanding Notes, the Company, the
Guarantors, if any, and the Trustee may amend or supplement this Indenture and the Notes for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of this Indenture or the Notes or of modifying in any
manner the rights of the Holders under this Indenture or the Notes, including the definitions herein; provided, however, that no such amendment or supplement shall, without the consent of the Holder of each outstanding Note affected
thereby: 
 (1) reduce the principal amount of Notes issued thereunder whose Holders must consent to an amendment, supplement
or waiver; 
 (2) reduce the principal of or change the fixed maturity of any Note or alter the provisions with respect to
the redemption of such Notes issued thereunder (other than provisions relating to Sections 3.9, 4.10 and 4.14 except as set forth in clause (10) below); 

(3) reduce the rate of or change the time for payment of interest on any Note issued thereunder; 

(4) waive a Default or Event of Default in the payment of principal of, or interest or premium on, the Notes issued thereunder
(except a rescission of acceleration of such Notes issued thereunder by the holders of at least a majority in aggregate principal amount of such Notes issued thereunder with respect to a nonpayment default and a waiver of the payment default that
resulted from such acceleration); 
 (5) make any Note payable in money other than that stated in the Notes; 

(6) make any change in the provisions of this Indenture relating to waivers of past Defaults or the rights of Holders of Notes
to receive payments of principal of, or interest or premium on, such Notes issued thereunder or impair the right of any holder of Notes to institute suit for the enforcement of any payment on or with respect to such Holder’s Notes; 

(7) waive a redemption payment with respect to any Note issued thereunder (other than a payment required by
Sections 3.9, 4.10 and 4.14 except as set forth in clause (10) below); 
 (8) make any change
in the ranking or priority provisions of any Note that would adversely affect the Holders of such Notes; 
 (9) modify the
Guarantees in any manner adverse to the Holders of the Notes; 
 (10) amend, change or modify in any material respect the
obligation of the Company to make and consummate a Change of Control Offer in respect of a Change of Control that has occurred or make and consummate an Asset Sale Offer in respect of an Asset Sale that has been consummated after a requirement to
make an Asset Sale Offer has arisen; or 
 (11) make any change in the preceding amendment and waiver provisions. 

  
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 The Holders of not less than a majority in principal amount of the outstanding Notes may on
behalf of the Holders of all the Notes waive any past Default under this Indenture and its consequences, except a Default: 

(1) in any payment in respect of the principal of (or premium, if any) or interest on any Notes (including any Note which is
required to have been purchased pursuant to an Offer to Purchase which has been made by the Company), or 
 (2) in respect of
a covenant or provision hereof which under this Indenture cannot be modified or amended without the consent of the Holder of each outstanding Note affected. 

It shall not be necessary for the consent of the Holders of Notes under this Section 9.2 to approve the particular form of any
proposed amendment or waiver, but it shall be sufficient if such consent approves the substance thereof. 
 After an amendment, supplement
or waiver under this Section 9.2 becomes effective, the Company shall mail to the Holders of Notes affected thereby a notice briefly describing the amendment, supplement or waiver. Any failure of the Company to mail such notice, or any
defect therein, shall not, however, in any way impair or affect the validity of any such amended or supplemental Indenture or waiver. 

SECTION 9.3 [Reserved]. 

SECTION 9.4 Revocation and Effect of Consents. 

Until an amendment, supplement or waiver becomes effective, a consent to it by a Holder of a Note is a continuing consent by the Holder and
every subsequent Holder of that Note or portion of the Note that evidences the same debt as the consenting Holder’s Note, even if notation of the consent is not made on the Note. However, any such Holder or subsequent Holder may revoke the
consent as to its Note if the Trustee receives written notice of revocation before the date the waiver, supplement or amendment becomes effective. When an amendment, supplement or waiver becomes effective in accordance with its terms, it thereafter
binds every Holder. 
 The Company may, but shall not be obligated to, fix a record date for determining which Holders consent to such
amendment, supplement or waiver. If the Company fixes a record date, the record date shall be fixed at (i) the later of 30 days prior to the first solicitation of such consent or the date of the most recent list of Holders furnished for
the Trustee prior to such solicitation pursuant to Section 2.5 hereof or (ii) such other date as the Company shall designate. 

SECTION 9.5 Notation on or Exchange of Notes. 

The Trustee may place an appropriate notation about an amendment, supplement or waiver, the text of which shall be provided by the Company, on
any Note thereafter authenticated. The Company, in exchange for all Notes, may issue and the Trustee shall authenticate new Notes that reflect the amendment, supplement or waiver. 

Failure to make the appropriate notation or issue a new Note shall not affect the validity and effect of such amendment, supplement or waiver.

 SECTION 9.6 Trustee to Sign Amendments, Etc. 

The Trustee, the Paying Agent and the Registrar shall sign any amended or supplemental indenture authorized pursuant to this
Article IX if the amendment or supplement does not adversely affect the rights, duties, liabilities or immunities of the Trustee, the Paying Agent and the Registrar. The Company and the Guarantors may not sign an amendment or
supplemental indenture until their respective Boards of Directors approve it. In signing or refusing to sign any amendment or supplemental indenture the Trustee, 

  
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the Paying Agent and the Registrar shall be entitled to receive and (subject to Section 7.1 hereof) shall be fully protected in relying upon an Officers’ Certificate and an
Opinion of Counsel stating that the execution of such amendment or supplemental indenture is authorized or permitted by this Indenture, that all conditions precedent thereto have been met or waived, that such amendment or supplemental indenture is
not inconsistent herewith, and that it will be valid and binding upon the Company in accordance with its terms. 
 ARTICLE X 

[RESERVED] 
 ARTICLE XI 

NOTE GUARANTEES 
 SECTION 11.1
Guarantees. 
 (a) Each Guarantor hereby jointly and severally, fully, unconditionally and irrevocably guarantees the Notes and
obligations of the Company hereunder and thereunder, and guarantees to each Holder of a Note authenticated and delivered by the Trustee and to the Trustee on behalf of such Holder, that: (i) the principal of and premium, if any, and interest on
the Notes shall be paid in full when due, whether at Stated Maturity, by acceleration, call for redemption or otherwise (including, without limitation, the amount that would become due but for the operation of the automatic stay under
Section 362(a) of the Bankruptcy Law), together with interest on the overdue principal, if any, and interest on any overdue interest, if any, to the extent lawful, and all other obligations of the Company to the Holders or the Trustee hereunder
or thereunder shall be paid in full or performed, all in accordance with the terms hereof and thereof; and (ii) in case of any extension of time of payment or renewal of any Notes or of any such other obligations, the same shall be paid in full
when due or performed in accordance with the terms of the extension or renewal, whether at Stated Maturity, by acceleration or otherwise. Each of the Guarantees shall be a guarantee of payment and not of collection. 

(b) Each Guarantor hereby agrees that its obligations hereunder shall be unconditional, irrespective of the validity, regularity or
enforceability of the Notes or this Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder with respect to any provisions hereof or thereof, the recovery of any judgment against the Company, any action to
enforce the same or any other circumstance which might otherwise constitute a legal or equitable discharge or defense of a Guarantor. 
 (c)
Each Guarantor hereby waives the benefits of diligence, presentment, demand for payment, filing of claims with a court in the event of insolvency or bankruptcy of the Company, any right to require a proceeding first against the Company or any other
Person, protest, notice and all demands whatsoever and covenants that the Guarantee of such Guarantor shall not be discharged as to any Note except by complete performance of the obligations contained in such Note and such Guarantee or as provided
for in this Indenture. Each of the Guarantors hereby agrees that, in the event of a default in payment of principal or premium, if any or interest on such Note, whether at its Stated Maturity, by acceleration, call for redemption, purchase or
otherwise, legal proceedings may be instituted by the Trustee on behalf of, or by, the Holder of such Note, subject to the terms and conditions set forth in this Indenture, directly against each of the Guarantors to enforce such Guarantor’s
Guarantee without first proceeding against the Company or any other Guarantor. Each Guarantor agrees that if, after the occurrence and during the continuance of an Event of Default, the Trustee or any of the Holders are prevented by applicable law
from exercising their respective rights to accelerate the maturity of the Notes, to collect interest on the Notes, 

  
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or to enforce or exercise any other right or remedy with respect to the Notes, such Guarantor shall pay to the Trustee for the account of the Holders, upon demand therefor, the amount that would
otherwise have been due and payable had such rights and remedies been permitted to be exercised by the Trustee or any of the Holders. 
 (d)
If any Holder or the Trustee is required by any court or otherwise to return to the Company or any Guarantor, or any custodian, trustee, liquidator or other similar official acting in relation to the Company or any Guarantor, any amount paid by any
of them to the Trustee or such Holder, the Guarantee of each of the Guarantors, to the extent theretofore discharged, shall be reinstated in full force and effect. This paragraph (d) shall remain effective notwithstanding any contrary action
which may be taken by the Trustee or any Holder in reliance upon such amount required to be returned. This paragraph (d) shall survive the termination of this Indenture. 

(e) Each Guarantor further agrees that, as between each Guarantor, on the one hand, and the Holders and the Trustee, on the other hand,
(x) the maturity of the obligations guaranteed hereby may be accelerated as provided in Article VI hereof for the purposes of the Guarantee of such Guarantor, notwithstanding any stay, injunction or other prohibition preventing such
acceleration in respect of the obligations guaranteed hereby, and (y) in the event of any acceleration of such obligations as provided in Article VI hereof, such obligations (whether or not due and payable) shall forthwith become
due and payable by each Guarantor for the purpose of the Guarantee of such Guarantor. 
 SECTION 11.2 Execution and Delivery of
Guarantee. 
 To evidence its Guarantee set forth in Section 11.1, each Guarantor agrees that a notation of such Guarantee
substantially in the form attached hereto as Exhibit B shall be endorsed on each Note authenticated and delivered by the Trustee. Such notation of Guarantee shall be signed on behalf of such Guarantor by an officer of such Guarantor (or,
if an officer is not available, by a board member or director) on behalf of such Guarantor by manual or facsimile signature. In case the officer, board member or director of such Guarantor who shall have signed such notation of Guarantee shall cease
to be such officer, board member or director before the Note on which such Guarantee is endorsed shall have been authenticated and delivered by the Trustee, such Note nevertheless may be authenticated and delivered as though the Person who signed
such notation of Guarantee had not ceased to be such officer, board member or director. 
 Each Guarantor agrees that its Guarantee set
forth in Section 11.1 shall remain in full force and effect and apply to all the Notes notwithstanding any failure to endorse on each Note a notation of such Guarantee. The delivery of any Note by the Trustee, after the authentication
thereof hereunder, shall constitute due delivery of any Guarantee set forth in this Indenture on behalf of the Guarantors. 
 SECTION 11.3
Severability. 
 In case any provision of any Guarantee shall be invalid, illegal or unenforceable, the validity, legality, and
enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 SECTION 11.4 Limitation of
Guarantors’ Liability. 
 Each Guarantor and by its acceptance hereof each Holder confirms that it is the intention of all such
parties that the Guarantee of such Guarantor not constitute a fraudulent transfer or conveyance for purposes of the Federal Bankruptcy Law, the Uniform Fraudulent Conveyance Act, the Uniform Fraudulent Transfer Act or any similar federal
or state law or the provisions of its local law relating 

  
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to fraudulent transfer or conveyance. To effectuate the foregoing intention, the Trustee, the Holders and Guarantors hereby irrevocably agree that the obligations of such Guarantor under its
Guarantee shall be limited to the maximum amount that will not, after giving effect to all other contingent and fixed liabilities of such Guarantor and after giving effect to any collections from, rights to receive contribution from or payments made
by or on behalf of any other Guarantor in respect of the obligations of such other Guarantor under its Guarantee, result in the obligations of such Guarantor under its Guarantee constituting a fraudulent transfer or conveyance. 

SECTION 11.5 Guarantors May Consolidate, Etc., on Certain Terms. 

(a) Except as otherwise provided in this Section 11.5(a), a Guarantor may not (1) consolidate with or merge with or into
(whether or not such Guarantor is the surviving Person) another Person; or (2) sell, assign, transfer, convey, lease or otherwise dispose of all or substantially all of its properties or assets; unless: 

(1) (a) such Guarantor is the surviving corporation; or (b) the Person formed by or surviving any such consolidation or
merger (if other than such Guarantor) or to which such sale, assignment, transfer, conveyance, lease or other disposition has been made is a corporation or limited liability company organized or existing under the laws of the United States, any
state of the United States or the District of Columbia (such Guarantor or such Person, including the Person to which such sale, assignment, transfer, conveyance, lease or other disposition has been made, as the case may be, being herein called the
“Successor Guarantor”); 
 (2) the Successor Guarantor (if other than such Guarantor) assumes all the
obligations of such Guarantor under the Guarantee and the Indenture pursuant to agreements reasonably satisfactory to the Trustee; 

(3) immediately after such transaction, no Event of Default exists; and 

(4) the Net Proceeds of any such sale or other disposition of a Guarantor are applied in accordance with the provisions of
Section 4.10 hereof. 
 In case of any such consolidation, merger, sale or conveyance and upon the assumption by the successor
Person, by supplemental indenture, executed and delivered, together with an Opinion of Counsel to the effect that such consolidation, merger, sale or conveyance was made in accordance with the provisions of this Indenture, to the Trustee and
satisfactory in form to the Trustee , of the Guarantee and the due and punctual performance of all of the covenants and conditions of this Indenture to be performed by the Guarantor, such successor Person shall succeed to and be substituted for the
Guarantor with the same effect as if it had been named herein as a Guarantor. All the Guarantees so issued shall in all respects have the same legal rank and benefit under this Indenture as the Guarantees theretofore and thereafter issued in
accordance with the terms of this Indenture as though all such Guarantees had been issued at the date of the execution hereof. 
 Upon
delivery to the Trustee of an Officers’ Certificate and an Opinion of Counsel to the effect that such sale or other disposition was made by the Company in accordance with the provisions of this Indenture, including without limitation
Section 4.10, the Trustee shall execute any documents reasonably required in order to evidence the release of any Guarantor from its obligations under its Guarantee 

Notwithstanding the foregoing, any Guarantor (A) may consolidate with, merge into or sell, assign, transfer, convey, lease or otherwise
dispose of all or part of its properties and assets to the Company or to another Guarantor or (B) dissolve, liquidate or wind up its affairs if at that time it does not hold any material assets. 

  
 -96- 

 SECTION 11.6 Releases Following Sale of Assets. 

Any Guarantor shall be released and relieved of any obligations under this Guarantee in the event that: 

(a) the sale, disposition or other transfer (including through merger or consolidation) of (x) Capital Stock of the
applicable Guarantor if after such sale, disposition or other transfer such Guarantor is no longer a Restricted Subsidiary, or (y) all or substantially all the assets of the applicable Guarantor; provided that, in each case, such sale,
disposition or other transfer is made in compliance with the provisions of this Indenture; 
 (b) the Company designates any
Restricted Subsidiary that is a Guarantor as an Unrestricted Subsidiary in accordance with the provisions of this Indenture; 

(c) in the case of any Restricted Subsidiary which after the Issue Date is required to guarantee the Notes pursuant to
Section 4.17 the release or discharge of the guarantee by such Restricted Subsidiary of all of the Indebtedness of the Company or any Restricted Subsidiary or the repayment of all of the Indebtedness which resulted in the obligation to
guarantee the Notes; 
 (d) the Company exercises its legal defeasance option or its covenant defeasance option pursuant to
Sections 8.2 or 8.3 or if its obligations under this Indenture are discharged in accordance with the terms of this Indenture; or 

(e) such Guarantor is also a guarantor or borrower under the Credit Agreement as in effect on the Issue Date and, at the time
of release of its Guarantee, (x) has been released from its guarantee of, and all pledges and security, if any, granted in connection with the Credit Agreement (which may be conditioned on the concurrent release hereunder), (y) is not an
obligor under any Indebtedness (other than Indebtedness permitted to be incurred pursuant to clause (8), (9), (11) or (16) of the definition of “Permitted Debt” and (z) does not guarantee any Indebtedness of the Company or
any Restricted Subsidiaries (other than any guarantee that will be released upon the release of the Guarantee hereunder). 
 Upon delivery
to the Trustee of an Officers’ Certificate and an Opinion of Counsel to the effect that such sale or other disposition was made by the Company in accordance with the provisions of this Indenture, including without limitation
Section 4.10, the Trustee shall execute any documents reasonably required in order to evidence the release of any Guarantor from its obligations under its Guarantee. 

Any Guarantor not released from its obligations under this Guarantee shall remain liable for the full amount of principal of and interest on
the Notes and for the other obligations of any Guarantor under this Indenture as provided in this Article XI. 
 SECTION 11.7
Release of a Guarantor. 
 Any Guarantor that is designated by the Board of Directors of the Company as an Unrestricted Subsidiary in
accordance with the terms of this Indenture shall, at such time, be deemed automatically and unconditionally released and discharged of its obligations under its Guarantee without any further action on the part of the Trustee or any Holder. The
Trustee shall deliver an appropriate instrument evidencing such release upon receipt of the Company’s request for such release accompanied by an Officers’ Certificate 

  
 -97- 

 
and an Opinion of Counsel certifying as to the compliance with this Section 11.7. Any Guarantor not so released shall remain liable for the full amount of principal of and interest on
the Notes as provided in its Guarantee. 
 SECTION 11.8 Benefits Acknowledged. 

Each Guarantor acknowledges that it will receive direct and indirect benefits from the financing arrangements contemplated by this Indenture
and that its guarantee and waivers pursuant to its Guarantee are knowingly made in contemplation of such benefits. 
 ARTICLE XII 

MISCELLANEOUS 
 SECTION 12.1
[Reserved]. 
 SECTION 12.2 Notices. 

Any notice or communication by the Company, any Guarantor or the Trustee to the others is duly given if in writing and delivered in Person or
mailed by first class mail (registered or certified, return receipt requested), telecopier or overnight air courier guaranteeing next day delivery, to the others’ address: 

If to the Company: 
 VWR Funding,
Inc. 
 Radnor Corporate Center 

Building One, Suite 200 
 100
Matsonford Road 
 Radnor, Pennsylvania 19087 

Attention: Treasurer 
 With a copy
to: 
 Kirkland & Ellis LLP 

300 North LaSalle 
 Chicago,
Illinois 60654 
 Facsimile: (312) 862-2232 

Attention: Dennis Myers, P.C. 
 If
to the Trustee: 
 Law Debenture Trust Company of New York 

400 Madison Avenue, 4th Floor 

New York, New York 10017 

Facsimile: (212) 750-1361 

Attention: Corporate Trust Services 

If to the Paying Agent: 
 Deutsche
Bank AG, London Branch 
 Winchester House 

1 Great Winchester Street 
 London
EC2N 2DB 
 United Kingdom 

Attention: Trust & Securities Services 

  
 -98- 

 If to the Registrar and Transfer Agent: 

Deutsche Bank Luxembourg S.A. 
 2,
Boulevard Konrad Adenauer, 
 1115 Luxembourg, Luxembourg 

The Company or the Trustee, by notice to the other, may designate additional or different addresses for subsequent notices or communications.

 All notices and communications (other than those sent to Holders) shall be deemed to have been duly given: at the time delivered by hand,
if personally delivered; five (5) Business Days after being deposited in the mail, postage prepaid, if mailed; when receipt acknowledged, if telecopied; and the next Business Day after timely delivery to the courier, if sent by overnight air
courier guaranteeing next Business Day delivery. 
 Any notice or communication to a Holder shall be mailed by first class mail, certified
or registered, return receipt requested, or by overnight air courier guaranteeing next Business Day delivery to its address shown on the register kept by the Registrar. Failure to mail a notice or communication to a Holder or any defect in it shall
not affect its sufficiency with respect to other Holders. 
 If a notice or communication is mailed in the manner provided above within the
time prescribed, it is duly given, whether or not the addressee receives it, except in the case of notices or communications given to the Trustee, which shall be effective only upon actual receipt. 

If the Company mails a notice or communication to Holders, it shall mail a copy to the Trustee and each Agent at the same time. 

SECTION 12.3 [Reserved] 

SECTION 12.4 Certificate and Opinion as to Conditions Precedent. 

Upon any request or application by the Company to the Trustee to take any action under this Indenture (other than the initial issuance of the
Notes), the Company shall furnish to the Trustee upon request: 
 (a) an Officers’ Certificate (which shall include the
statements set forth in Section 12.5 hereof) stating that, in the opinion of the signers, all conditions precedent and covenants, if any, provided for in this Indenture relating to the proposed action have been satisfied; and 

(b) an Opinion of Counsel (which shall include the statements set forth in Section 12.5 hereof) stating that, in
the opinion of such counsel, all such conditions precedent and covenants have been satisfied; 
 provided that no Opinion of Counsel
as set forth in clause (2) above shall be required in connection with the order of the Issuer to authenticate and deliver the Initial Notes in the aggregate principal amount of €503.8 million on the date hereof pursuant to
Section 2.2 hereof. 

  
 -99- 

 SECTION 12.5 Statements Required in Certificate or Opinion. 

Each certificate or opinion with respect to compliance with a condition or covenant provided for in this Indenture shall include: 

(a) a statement that the Person making such certificate or opinion has read such covenant or condition; 

(b) a brief statement as to the nature and scope of the examination or investigation upon which the statements or opinions
contained in such certificate or opinion are based; 
 (c) a statement that, in the opinion of such Person, he or she has
made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such covenant or condition has been satisfied; and 

(d) a statement as to whether or not, in the opinion of such Person, such condition or covenant has been satisfied. 

In giving such Opinion of Counsel, counsel may rely as to factual matters on an Officer’s Certificate or on certificates of public
officials. 
 SECTION 12.6 Rules by Trustee and Agents. 

The Trustee may make reasonable rules for action by or at a meeting of Holders. The Registrar or Paying Agent may make reasonable rules and
set reasonable requirements for its functions. 
 SECTION 12.7 No Personal Liability of Directors, Officers, Employees and
Stockholders. 
 No director, officer, employee, incorporator, stockholder, unitholder or member of the Company, any of its Subsidiaries
or any of its direct or indirect parent companies, as such, will have any liability for any obligations of the Company or any Guarantor under the Notes, this Indenture, the Guarantees, or for any claim based on, in respect of, or by reason of, such
obligations or their creation. Each holder of Notes by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for issuance of the Notes. The waiver may not be effective to waive liabilities
under the federal securities laws, and it is the view of the Commission that such waiver is against public policy. 
 SECTION 12.8
Governing Law. 
 THE INTERNAL LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO CONFLICTS OF LAWS PRINCIPLES THEREOF, SHALL GOVERN
AND BE USED TO CONSTRUE THIS INDENTURE, THE NOTES AND THE GUARANTEES. 
 SECTION 12.9 No Adverse Interpretation of Other Agreements.

 This Indenture may not be used to interpret any other indenture, loan or debt agreement of the Company or its Subsidiaries or of any
other Person. Any such indenture, loan or debt agreement may not be used to interpret this Indenture. 

  
 -100- 

 SECTION 12.10 Successors. 

All agreements of the Company and the Guarantors in this Indenture and the Notes and the Guarantees, as applicable, shall bind their
respective successors and assigns. All agreements of the Trustee in this Indenture shall bind its successors and assigns. 
 SECTION 12.11
Severability. 
 In case any provision in this Indenture or in the Notes shall be invalid, illegal or unenforceable, the validity,
legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 
 SECTION 12.12
Counterpart Originals. 
 The parties may sign any number of copies of this Indenture. Each signed copy shall be an original, but all
of them together represent the same agreement. 
 SECTION 12.13 Table of Contents, Headings, Etc. 

The Table of Contents, Cross-Reference Table and Headings of the Articles and Sections of this Indenture have been inserted for convenience of
reference only, are not to be considered a part of this Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 

SECTION 12.14 Acts of Holders. 

(a) Any request, demand, authorization, direction, notice, consent, waiver or other action provided by this Indenture to be given or taken by
Holders may be embodied in and evidenced by one or more instruments of substantially similar tenor signed by such Holders in person or by agent duly appointed in writing; and, except as herein otherwise expressly provided, such action shall become
effective when such instrument or instruments are delivered to the Trustee and, where it is hereby expressly required, to the Company. Such instrument or instruments (and the action embodied therein and evidenced thereby) are herein sometimes
referred to as the “Act” of Holders signing such instrument or instruments. Proof of execution of any such instrument or of a writing appointing any such agent shall be sufficient for any purpose of this Indenture and conclusive in
favor of the Trustee and the Company, if made in the manner provided in this Section 12.14. 
 (b) The fact and date of the
execution by any Person of any such instrument or writing may be proved by the affidavit of a witness of such execution or by a certificate of a notary public or other officer authorized by law to take acknowledgments of deeds, certifying that the
individual signing such instrument or writing acknowledged to such officer the execution thereof. Where such execution is by a signer acting in a capacity other than such signer’s individual capacity, such certificate or affidavit shall also
constitute sufficient proof of such signer’s authority. The fact and date of the execution of any such instrument or writing, or the authority of the Person executing the same, may also be proved in any other manner which the Trustee deems
sufficient. 
 (c) The ownership of Notes shall be proved by the Holder list maintained under Section 2.5 hereunder. 

(d) Any request, demand, authorization, direction, notice, consent, waiver or other Act of the Holder of any Note shall bind every future
Holder of the same Note and the holder of every Note issued upon the registration of transfer thereof or in exchange therefor or in lieu thereof in respect of anything done, omitted or suffered to be done by the Trustee or the Company in reliance
thereon, whether or not notation of such action is made upon such Note. 

  
 -101- 

 (e) If the Company shall solicit from the Holders any request, demand, authorization, direction,
notice, consent, waiver or other Act, the Company may, at its option, by or pursuant to a Board Resolution, fix in advance a record date for the determination of Holders entitled to give such request, demand, authorization, direction, notice,
consent, waiver or other Act, but the Company shall have no obligation to do so. If such a record date is fixed, such request, demand, authorization, direction, notice, consent, waiver or other Act may be given before or after such record date, but
only the Holders of record at the close of business on such record date shall be deemed to be Holders for the purposes of determining whether Holders of the requisite proportion of outstanding Notes have authorized or agreed or consented to such
request, demand, authorization, direction, notice, consent, waiver or other Act, and for that purpose the outstanding Notes shall be computed as of such record date; provided that no such authorization, agreement or consent by the Holders on
such record date shall be deemed effective unless it shall become effective pursuant to the provisions of this Indenture not later than six months after the record date. 

SECTION 12.15 Waiver of Jury Trial. 

EACH OF PARTIES HERETO HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY
LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 
 SECTION 12.16 Force
Majeure. 
 In no event shall the Trustee be responsible or liable for any failure or delay in the performance of its obligations under
this Indenture arising out of or caused by, directly or indirectly, forces beyond its reasonable control, including without limitation strikes, work stoppages, accidents, acts of war or terrorism, civil or military disturbances, nuclear or natural
catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software, or hardware) services. 

SECTION 12.17 USA Patriot Act. 

The parties hereto acknowledge that in accordance with Section 326 of the USA Patriot Act (the “Patriot Act”), the
Trustee, like all financial institutions and in order to help fight the funding of terrorism and money laundering, is required to obtain, verify and record information that identifies each person or legal entity that establishes a relationship or
opens an account with the Trustee. The parties to this Indenture agree that they will provide the Trustee with such information as it may reasonably request in order for the Trustee to satisfy the requirements of the Patriot Act. 

SECTION 12.18 Judgment Currency. 

Any payment on account of an amount that is payable in euros (the “Required Currency”), which is made to or for the account
of any holder of the Notes or the Trustee in lawful currency of any other jurisdiction (the “Judgment Currency”), whether as a result of any judgment or order or the enforcement thereof or the liquidation of the Company or a
Guarantor, shall constitute a discharge of the Company or the Guarantor’s obligation under this Indenture and the Notes or Guarantee, as the case may be, only to the extent of the amount of the Required Currency with such Holder or the Trustee,
as the case may be, could purchase in the London foreign exchange markets with the amount of the Judgment Currency in accordance with normal banking procedures at the rate of exchange prevailing on the first Business Day following receipt of the
payment in the Judgment Currency. If the amount of the Required Currency that 

  
 -102- 

 
could be so purchased is less than the amount of the Required Currency originally due to such Holder or the Trustee, as the case may be, the Company shall indemnify and hold harmless the Holder
or the Trustee, as the case may be, from and against all loss or damage arising out of, or as a result of, such deficiency. This indemnity shall constitute an obligation separate and independent from the other obligations contained in this Indenture
or the Notes, shall give rise to a separate and independent cause of action, shall apply irrespective of any indulgence granted by any Holder or the Trustee from time to time and shall continue in full force and effect notwithstanding any judgment
or order for a liquidated sum in respect of an amount due hereunder or under any judgment or order. 
 [Signatures on following page] 

  
 -103- 

 IN WITNESS WHEREOF, the parties hereto have caused this Indenture to be duly executed as of the
day and year first above written. 
  

					
	VWR FUNDING, INC.
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Corporate Treasurer
	
	VWR INTERNATIONAL, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Corporate Treasurer
	
	VWR CHEMICALS, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	VWR MANAGEMENT SERVICES, LLC
		
	By:		VWR International, LLC
	Its:		Sole Member
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Corporate Treasurer
	
	AMRESCO, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer

  
 S-1 

 
					
	UNITED BIOCHEMICALS, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	BIOEXPRESS, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	TEK PRODUCTS, INC.
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	STI COMPONENTS, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	INTEGRA COMPANIES, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer
	
	NATIONAL BIOCHEMICALS, LLC
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer

  
 S-2 

 
					
	VWR GLOBAL HOLDINGS, INC.
		
	By:		 /s/ James M. Kalinovich

			Name:		James M. Kalinovich
			Title:		Vice President and Treasurer

  
 S-3 

 
			
	LAW DEBENTURE TRUST COMPANY OF NEW YORK, as Trustee
		
	By:		 /s/ Frank Godino

			Name:  Frank Godino
			Title:    Vice President
	
	 DEUTSCHE BANK AG, LONDON BRANCH,
 as
Paying Agent

		
	By:		 /s/ Tracey Dean

			Name:  Tracey Dean
			Title:    AVP
		
	By:		 /s/ Mahen Surnam

			Name:  Mahen Surnam
			Title:    VP
	
	 DEUTSCHE BANK LUXEMBOURG S.A.,
 as
Registrar and Transfer Agent

		
	By:		 /s/ Tracey Dean

			Name:  Tracey Dean
			Title:    Attorney
		
	By:		 /s/ Mahen Surnam

			Name:  Mahen Surnam
			Title:    Attorney

  
 S-4 

 EXHIBIT A 

FORM OF NOTE 
 (Face of 4.625%
Note due 2022) 
 [Global Note Legend] 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE COMMON DEPOSITARY, TO THE COMPANY OR ITS AGENT FOR REGISTRATION OR
TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF THE COMMON DEPOSITARY OR A NOMINEE OF THE COMMON DEPOSITARY OR TO SUCH OTHER ENTITY AS IS REQUIRED BY AN AUTHORIZED REPRESENTATIVE OF THE COMMON DEPOSITARY OR
SUCH OTHER REPRESENTATIVE OF THE COMMON DEPOSITARY OR SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE COMMON DEPOSITARY (AND ANY PAYMENT HEREON IS MADE TO THE COMMON DEPOSITARY OR A NOMINEE OF THE COMMON DEPOSITARY OR TO SUCH
OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE COMMON DEPOSITARY) ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF, A NOMINEE OF THE COMMON
DEPOSITARY, HAS AN INTEREST HEREIN. 
 TRANSFERS OF THIS GLOBAL SECURITY SHALL BE LIMITED TO TRANSFERS IN WHOLE, BUT NOT IN PART, TO THE
COMMON DEPOSITARY OR A NOMINEE OF THE COMMON DEPOSITARY OR TO A SUCCESSOR THEREOF OR SUCH SUCCESSOR’S NOMINEE. 
 [Restricted Notes
Legend] 
 THIS NOTE AND THE RELATED GUARANTEES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES
ACT”), OR THE SECURITIES LAWS OF ANY STATE OR OTHER JURISDICTION. NEITHER THIS NOTE NOR THE RELATED GUARANTEES NOR ANY INTEREST OR PARTICIPATION HEREIN MAY BE OFFERED, SOLD, ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN
THE ABSENCE OF SUCH REGISTRATION OR UNLESS SUCH TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT. THE HOLDER OF THIS NOTE AND THE RELATED GUARANTEES BY ITS ACCEPTANCE HEREOF AGREES TO OFFER, SELL OR
OTHERWISE TRANSFER SUCH NOTE, PRIOR TO THE DATE (THE “RESALE RESTRICTION TERMINATION DATE”) WHICH IS [IN THE CASE OF RULE 144A NOTES: ONE YEAR AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF, THE ORIGINAL ISSUE DATE OF THE ISSUANCE OF
ANY ADDITIONAL NOTES AND THE LAST DATE ON WHICH THE ISSUER OR ANY AFFILIATE OF THE ISSUER WAS THE OWNER OF THIS NOTE AND THE RELATED GUARANTEES (OR ANY PREDECESSOR OF THIS NOTE AND THE RELATED GUARANTEES)] [IN THE CASE OF REGULATION S NOTES: 40 DAYS
AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF AND THE DATE ON WHICH THIS NOTE (OR ANY PREDECESSOR OF THIS NOTE AND THE RELATED GUARANTEES) WAS FIRST OFFERED TO PERSONS OTHER THAN DISTRIBUTORS (AS DEFINED IN RULE 902 OF REGULATION S) IN RELIANCE
ON REGULATION S] ONLY (A) TO THE ISSUER OR ANY SUBSIDIARY THEREOF. (B) PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT, (C) FOR SO LONG AS THE NOTES ARE ELIGIBLE FOR RESALE PURSUANT TO RULE 144A UNDER THE

  
 A-1 

 
SECURITIES ACT (“RULE 144A”), TO A PERSON IT REASONABLY BELIEVES IS A “QUALIFIED INSTITUTIONAL BUYER” AS DEFINED IN RULE 144A THAT PURCHASES FOR ITS OWN ACCOUNT OR FOR THE
ACCOUNT OF A QUALIFIED INSTITUTIONAL BUYER TO WHOM NOTICE IS GIVEN THAT THE TRANSFER IS BEING MADE IN RELIANCE ON RULE 144A, (D) PURSUANT TO OFFERS AND SALES TO NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF
REGULATION S UNDER THE SECURITIES ACT OR (E) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, SUBJECT TO THE ISSUER’S AND THE TRUSTEE’S RIGHT PRIOR TO ANY SUCH OFFER, SALE OR TRANSFER
PURSUANT TO CLAUSES (C), (D) OR (E) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATION AND/OR OTHER INFORMATION SATISFACTORY TO EACH OF THEM. [IN THE CASE OF REGULATION S NOTES’ BY ITS ACQUISITION HEREOF, THE HOLDER
HEREOF REPRESENTS THAT IT IS NEITHER A U.S. PERSON NOR IS IT PURCHASING FOR THE ACCOUNT OF A U.S. PERSON AND IS ACQUIRING THE THIS NOTE IN AN OFFSHORE TRANSACTION IN ACCORDANCE WITH REGULATION S UNDER THE SECURITIES ACT.] THIS LEGEND WILL BE REMOVED
UPON THE REQUEST OF A HOLDER ONLY AT THE DIRECTION AND IN THE ABSOLUTE DISCRETION OF THE ISSUER AFTER THE RESALE RESTRICTION TERMINATION DATE, AS APPLICABLE. 

[Temporary Regulation S Notes Legend] 

THE RIGHTS ATTACHING TO THIS REGULATION S TEMPORARY GLOBAL NOTE, AND THE CONDITIONS AND PROCEDURES GOVERNING ITS EXCHANGE FOR CERTIFICATED
NOTES, ARE AS SPECIFIED IN THE INDENTURE (AS DEFINED HEREIN). 

  
 A-2 

 VWR FUNDING, INC. 

4.625% Senior Notes due 2022 
  

			
	No.		€
			COMMON CODE
			ISIN NO.

 VWR Funding, Inc. (the “Company”, which includes any successor entity) promises to pay to
             or registered assigns, the principal sum of      (€    ) on April 15, 2022. 

Interest Payment Dates: April 15 and October 15, beginning October 15, 2015 

Record Dates: April 1 and October 1 

Reference is made to further provisions of this Note set forth on the reverse hereof, which further provisions shall for all purposes have the
same effect as set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the Trustee referred to on
the reverse hereof by manual signature, this Note shall not be entitled to any benefits under the Indenture referred to on the reverse hereof or be valid or obligatory for any purpose. 

  
 A-3 

 IN WITNESS WHEREOF, the Company has caused this Note to be signed manually or by facsimile by its
duly authorized officers. 
 Dated: 
  

			
	VWR FUNDING, INC.
		
	By:		  

			Name:
			Title:

  
 A-4 

 This is one of the Notes referred to in the within-mentioned Indenture: 

Dated: 
  

			
	LAW DEBENTURE TRUST COMPANY OF NEW YORK, as Trustee
		
	By:		  

			Name:
			Title:

  
 A-5 

 (Back of 4.625% Note) 

4.625% Senior Notes due 2022 

Capitalized terms used herein shall have the meanings assigned to them in the Indenture referred to below unless otherwise indicated. 

(1) Interest. VWR Funding, Inc., a Delaware corporation (the “Company,” which includes any successor entity) promises
to pay interest on the principal amount of this Note at 4.625% per annum from March 25, 2015 until maturity. 
 The Company will
pay interest in euros (except as otherwise provided herein) semiannually in arrears on April 15 and October 15, commencing on October 15, 2015 or if any such day is not a Business Day, on the next succeeding Business Day (each an
“Interest Payment Date”). Interest on the Notes shall accrue from the most recent date to which interest has been paid or, if no interest has been paid, from March 25, 2015; provided that if there is no existing Default
or Event of Default in the payment of interest, and if this Note is authenticated between a record date referred to on the face hereof and the next succeeding Interest Payment Date (but after March 25, 2015), interest shall accrue from such
next succeeding Interest Payment Date, except in the case of the original issuance of Notes, in which case interest shall accrue from the date of authentication. The Company shall pay interest (including post-petition interest in any proceeding
under any Bankruptcy Law) on overdue principal to the extent lawful; it shall pay interest (including post-petition interest in any proceeding under any Bankruptcy Law) on overdue installments of interest (without regard to any applicable grace
period) to the extent lawful. Interest shall be computed on the basis of a 360-day year comprised of twelve 30-day months. The interest rate on the Notes will in no
event be higher than the maximum rate permitted by New York law as the same may be modified by United States law of general application. 

(2) Method of Payment. The Company will pay Interest on the Notes (except defaulted interest) on the applicable Interest Payment Date
to the Persons who are registered Holders of Notes at the close of business on the April 1 and October 1 preceding the Interest Payment Date, even if such Notes are cancelled after such record date and on or before such Interest Payment
Date, except as provided in Section 2.12 of the Indenture with respect to defaulted interest. The Notes shall be payable as to principal, premium, if any, and interest at the office or agency of the Company maintained for such purpose,
or, at the option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of immediately available funds shall be required
with respect to principal of, premium, if any, and interest on, all Global Notes and all other Notes the Holders of which shall have provided, at least three Business Days prior to the applicable payment date, written wire transfer instructions to
the Company and the Paying Agent. Such payment shall be in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts. 

Any payments of principal of this Note prior to Stated Maturity shall be binding upon all future Holders of this Note and of any Note issued
upon the registration of transfer hereof or in exchange hereof or in lieu hereof, whether or not noted hereon. The amount due and payable at the maturity of this Note shall be payable only upon presentation and surrender of this Note at an office of
the Trustee or the Trustee’s agent appointed for such purposes. 
 (3) Paying Agent, Transfer Agent and Registrar. Initially,
Deutsche Bank AG, London Branch shall act as Paying Agent and Deutsche Bank Luxembourg S.A. shall act as Registrar and Transfer Agent. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its
Restricted Subsidiaries may act in any such capacity. 

  
 A-6 

 (4) Indenture. The Company issued the Notes under an Indenture, dated as of March 25,
2015 (the “Indenture”), by and among the Company, the Guarantors, the Paying Agent, the Registrar and Transfer Agent and the Trustee. The terms of the Notes include those stated in the Indenture. To the extent the provisions of this
Note are inconsistent with the provisions of the Indenture, the Indenture shall govern. The Notes are subject to all such terms, and Holders are referred to the Indenture and such Act for a statement of such terms. The Notes issued on the Issue Date
are senior obligations of the Company limited to €503,800,000 in aggregate principal amount, plus amounts, if any, sufficient to pay premium and interest on outstanding Notes as set forth in Paragraph 2 hereof. The Indenture permits
the issuance of Additional Notes subject to compliance with certain conditions. 
 The payment of principal and interest on the Notes is
unconditionally guaranteed on a senior basis by the Guarantors. 
 (5) Optional Redemption. 

(a) The Notes may be redeemed in whole or in part, at any time prior to April 15, 2018, at the option of the Company upon not less than
30 nor more than 60 days’ prior notice mailed by first-class mail to each Holder’s registered address, at a redemption price equal to 100% of the principal amount of the Notes redeemed plus the Applicable Premium as of, and
accrued and unpaid interest, if any, to, the applicable redemption date (subject to the right of Holders on the relevant record date to receive interest due on the relevant interest payment date). 

(b) The Notes are subject to redemption, at the option of the Company, in whole or in part, at any time on or after April 15, 2018, upon
not less than 30 nor more than 60 days’ notice, at the following Redemption Prices (expressed as a percentage of the principal amount to be redeemed) set forth below, plus accrued and unpaid interest, if any, to, but not including, the
redemption date (subject to the right of Holders of record on the relevant regular record date to receive interest due on an interest payment date that is on or prior to the redemption date) if redeemed during the twelve-month period beginning on
April 15 of the years indicated below: 
  

					
	 Year
	  	Percentage	 
	 2018
	  	 	102.3125	% 
	 2019
	  	 	101.1563	% 
	 2020 and thereafter
	  	 	100.0000	% 

 (c) In addition to the optional redemption of the Notes in accordance with the provisions of the preceding
paragraph, prior to April 15, 2018, the Company may on one or more occasions, with the net cash proceeds of one or more Equity Offerings, redeem up to 35% of the aggregate principal amount of the outstanding Notes at a Redemption Price of
104.625% of the principal amount thereof, plus accrued and unpaid interest, if any, thereon to the date of redemption (provided that if the Equity Offering is an offering by Parent or any of its direct or indirect parent companies, a
portion of the net cash proceeds thereof equal to the amount required to redeem any such Notes is contributed to the equity capital of the Company); provided that at least 65% of the aggregate principal amount of Notes issued under the
Indenture (including any Additional Notes) remains outstanding immediately after the occurrence of any such redemption and that any such redemption occurs within 90 days following the closing of any such Equity Offering. 

(d) Notice of any redemption upon an Equity Offering may be given prior to the completion of the related Equity Offering. Notice of any
redemption, including, without limitation, upon an Equity Offering, may, at the Company’s discretion, be subject to one or more conditions precedent, including, but not limited to completion of the related Equity Offering. 

  
 A-7 

 (e) The Company may at any time and from time to time purchase Notes in the open market by tender
offer, negotiated transactions or otherwise, in accordance with applicable securities laws. 
 (f) If the Company effects an optional
redemption of the Notes, it will, for so long as the Notes are listed on the Official List of the Irish Stock Exchange and admitted for trading on the Global Exchange Market thereof and the rules of the Irish Stock Exchange so require, inform the
Irish Stock Exchange of such optional redemption and confirm the aggregate principal amount of the Notes that will remain outstanding immediately after such redemption. 

(6) Mandatory Redemption. The Company shall not be required to make mandatory redemption or sinking fund payments with respect to the
Notes. 
 (7) Repurchase at Option of Holder. 

(a) Upon the occurrence of a Change of Control, each Holder will have the right to require the Company to repurchase all or any part (equal to
€100,000 or integral multiples of €1,000 in excess thereof) of such Holder’s Notes pursuant to the offer described below (the “Change of Control Offer”) at an offer price in cash equal to 101% of the aggregate
principal amount thereof plus accrued and unpaid interest, if any, thereon to the date of purchase. Within 30 days following any Change of Control, the Company will (i) mail a notice to each Holder describing the transaction or
transactions that constitute the Change of Control setting forth the procedures governing the Change of Control Offer required by the Indenture and (ii) if at the time of such notice the Notes are listed on the Irish Stock Exchange, or any
other securities exchange, and admitted for trading on the Global Exchange Market of the Irish Stock Exchange, to the extent the rules of the Irish Stock Exchange or such other securities exchange so require, cause a notice of the Change of Control
Offer to be published in a leading newspaper of general circulation in Ireland (which is expected to be The Irish Times) or, to the extent and in a manner permitted by such rules, post such notice on the official website of the Irish Stock
Exchange (www.ise.ie) or through other methods permitted by such rules. 
 (b) Upon the occurrence of certain Asset Sales, the
Company may be required to offer to purchase Notes. 
 (c) Holders of the Notes that are the subject of an offer to purchase will receive
notice of an Offer to Purchase pursuant to an Asset Sale or a Change of Control from the Company prior to any related purchase date and may elect to have such Notes purchased by completing the form titled “Option of Holder to Elect
Purchase” appearing below. 
 (8) Notice of Redemption. Notice of redemption shall be mailed by first-class mail at least
30 days but not more than 60 days before the redemption date to each Holder whose Notes are to be redeemed at its registered address. Notes in denominations larger than €100,000 may be redeemed in part but only in minimum
denominations of €100,000 and integral multiples of €1,000 thereof, unless all of the Notes held by a Holder are to be redeemed. On and after the redemption date, interest will cease to accrue on the Notes or portions hereof called for
redemption. 
 (9) Successor Entity. When a successor entity assumes, in accordance with the Indenture, all of the obligations of its
predecessor under the Notes and Indenture, and immediately before and after such transaction, no Event of Default Exists and certain other conditions are satisfied, the predecessor entity will be released from those obligations. 

  
 A-8 

 (10) Denominations, Transfer, Exchange. The Notes are in registered form without coupons
in initial denominations of €100,000 and integral multiples of €1,000 thereof. The transfer of the Notes may be registered and the Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder,
among other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of
any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part. Also, it need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to
be redeemed or during the period between a record date and the corresponding Interest Payment Date. 
 (11) Persons Deemed Owners.
The registered holder of a Note may be treated as its owner for all purposes. 
 (12) Amendment, Supplement and Waiver. Subject to
the following paragraphs, the Indenture and the Notes may be amended or supplemented with the consent of the Holders of at least a majority in aggregate principal amount of the outstanding Notes, and any existing Default or Event of Default or
compliance with any provision of the Indenture or the Notes may be waived with the consent of the Holders of a majority in aggregate principal amount of the outstanding Notes. 

Notwithstanding Section 9.2 of the Indenture, without the consent of any Holders, the Company, the Guarantors, if any, and the
Trustee upon receipt of an Officers’ Certificate of no material adverse effect to the Holders and an Opinion of Counsel, at any time and from time to time, may amend or supplement the Indenture for any of the following purposes: 

(1) to cure any ambiguity, mistake, defect or inconsistency; 

(2) to provide for uncertificated Notes in addition to or in place of certificated Notes; 

(3) to provide for the assumption by a Successor Company or a successor company of a Guarantor, as applicable, of the
Company’s or such Guarantor’s obligations under the Indenture, the Notes or any Guarantee; 
 (4) to make any
change that would provide any additional rights or benefits to the Holders of Notes or that does not adversely affect the legal rights under the Indenture of any such Holder; 

(5) to secure the Notes; 

(6) [reserved]; 

(7) to add a Guarantee of the Notes; 

(8) to release a Guarantor upon its sale or designation as an Unrestricted Subsidiary or other permitted release from its
Guarantee; provided that such sale, designation or release is in accordance with the applicable provisions of the Indenture; or 

(9) to conform the text of the Indenture, Notes or Guarantees to any provision of the “Description of Notes” in the
Offering Circular. 
 With the consent of the Holders of not less than a majority in aggregate principal amount of the outstanding Notes,
the Company, the Guarantors, if any, and the Trustee may amend or supplement the 

  
 A-9 

 
Indenture for the purpose of adding any provisions to or changing in any manner or eliminating any of the provisions of the Indenture or the Notes or of modifying in any manner the rights of the
Holders under the Indenture or the Notes, including the definitions herein; provided, however, that no such amendment or supplement shall, without the consent of the Holder of each outstanding Note affected thereby: 

(1) reduce the principal amount of Notes issued thereunder whose Holders must consent to an amendment, supplement or waiver;

 (2) reduce the principal of or change the fixed maturity of any Note or alter the provisions with respect to the
redemption of such Notes issued thereunder (other than provisions relating to Sections 3.9, 4.10 and 4.14 except as set forth in clause (10) below); 

(3) reduce the rate of or change the time for payment of interest on any Note issued thereunder; 

(4) waive a Default or Event of Default in the payment of principal of, or interest or premium on the Notes issued thereunder
(except a rescission of acceleration of such Notes issued thereunder by the holders of at least a majority in aggregate principal amount of such Notes issued thereunder with respect to a nonpayment default and a waiver of the payment default that
resulted from such acceleration); 
 (5) make any Note payable in money other than that stated in the Notes; 

(6) make any change in the provisions of the Indenture relating to waivers of past Defaults or the rights of Holders of Notes
to receive payments of principal of, or interest or premium on, such Notes issued thereunder or impair the right of any holder of Notes to institute suit for the enforcement of any payment on or with respect to such Holder’s Notes; 

(7) waive a redemption payment with respect to any Note issued thereunder (other than a payment required by
Sections 3.9, 4.10 and 4.14 except as set forth in clause (10) below); 
 (8) make any change
in the ranking, priority or subordination provisions of any Note that would adversely affect the Holders of such Notes; 

(9) modify the Guarantees in any manner adverse to the Holders of the Notes; 

(10) amend, change or modify in any material respect the obligation of the Company to make and consummate a Change of Control
Offer in respect of a Change of Control that has occurred or make and consummate an Asset Sale Offer in respect of an Asset Sale that has been consummated after a requirement to make an Asset Sale Offer has arisen; or 

(11) make any change in the preceding amendment and waiver provisions. 

The Holders of not less than a majority in aggregate principal amount of the outstanding Notes may on behalf of the Holders of all the Notes
waive any past Default under the Indenture and its consequences, except a Default: 
 (1) in any payment in respect of the
principal of (or premium, if any) or interest on any Notes (including any Note which is required to have been purchased pursuant to an Offer to Purchase which has been made by the Company), or 

(2) in respect of a covenant or provision hereof which under the Indenture cannot be modified or amended without the consent of
the Holder of each outstanding Note affected. 

  
 A-10 

 It shall not be necessary for the consent of the Holders of Notes under Section 9.2
of the Indenture to approve the particular form of any proposed amendment or waiver, but it shall be sufficient if such consent approves the substance thereof. 

After an amendment, supplement or waiver under Section 9.2 of the Indenture becomes effective, the Company shall mail to the
Holders of Notes affected thereby a notice briefly describing the amendment, supplement or waiver. Any failure of the Company to mail such notice, or any defect therein, shall not, however, in any way impair or affect the validity of any such
amended or supplemental Indenture or waiver. 
 (13) Defaults and Remedies. Events of Default include: 

(1) the Company defaults in payment when due and payable, upon redemption, acceleration or otherwise, of principal of, or
premium, if any, on the Notes; 
 (2) the Company defaults in the payment when due of interest on or with respect to the
Notes and such default continues for a period of 30 days; 
 (3) the Company defaults in the performance of, or breaches
any covenant, warranty or other agreement contained in, the Indenture (other than a default in the performance or breach of a covenant, warranty or agreement which is specifically dealt with in clause (1) or (2) above) and such default or
breach continues for a period of 60 days after the notice specified below or 90 days if such default is with respect to the covenant described under Section 4.3; 

(4) a default under any mortgage, indenture or instrument under which there is issued or by which there is secured or evidenced
any Indebtedness for money borrowed by the Company or any Restricted Subsidiary or the payment of which is guaranteed by the Company or any Restricted Subsidiary (other than Indebtedness owed to the Company or a Restricted Subsidiary), whether such
Indebtedness or guarantee now exists or is created after the Issue Date, if (A) such default either (1) results from the failure to pay any such Indebtedness at its stated final maturity (after giving effect to any applicable grace
periods) or (2) relates to an obligation other than the obligation to pay principal of any such Indebtedness at its stated final maturity and results in the holder or holders of such Indebtedness causing such Indebtedness to become due prior to
its stated maturity and (B) the principal amount of such Indebtedness, together with the principal amount of any other such Indebtedness in default for failure to pay principal at stated final maturity (after giving effect to any applicable
grace periods), or the maturity of which has been so accelerated, aggregate $65.0 million (or its foreign currency equivalent) or more at any one time outstanding; 

(5) the failure by the Company or any Significant Subsidiary to pay final judgments aggregating in excess of $65.0 million
(other than any judgments covered by indemnities or insurance policies issued by reputable and creditworthy companies), which final judgments remain unpaid, undischarged and unstayed for a period of more than 60 days after the applicable
judgment becomes final and non-appealable; 
 (6) the Guarantee of Parent or a Significant Subsidiary that is a Guarantor or
any group of Subsidiaries that are Guarantors and that, taken together as of the date of the most recent audited financial statements of the Company, would constitute a Significant Subsidiary ceases to

  
 A-11 

 
be in full force and effect (except as contemplated by the terms hereof) or Parent or any Guarantor denies or disaffirms its obligations under the Indenture or any Guarantee, other than by reason
of the release of the Guarantee in accordance with the terms of the Indenture; or 
 (7) (i) the Company, any Restricted
Subsidiary that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary, pursuant to or within the meaning of any Bankruptcy Law: 

(a) commences a voluntary case, 

(b) consents to the entry of an order for relief against it in an involuntary case, 

(c) consents to the appointment of a custodian of it or for all or substantially all of its property, 

(d) makes a general assignment for the benefit of its creditors, or 

(e) generally is not paying its debts as they become due; 

(ii) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(a) is for relief against the Company or any Restricted Subsidiary that is a Significant Subsidiary or any group of Restricted
Subsidiaries that, taken together, would constitute a Significant Subsidiary, in an involuntary case; 
 (b) appoints a
custodian of the Company or any Restricted Subsidiary that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken together, would constitute a Significant Subsidiary or for all or substantially all of the property of the
Company or any of its Restricted Subsidiaries; or 
 (c) orders the liquidation of the Company or any Restricted Subsidiary
that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken together, would constitute a Significant Subsidiary and the order or decree remains unstayed and in effect for 60 consecutive days. 

If an Event of Default (other than an Event of Default specified in clause (7) above with respect to the Company) shall occur and be
continuing, the Trustee or the Holders of at least 25% in aggregate principal amount of the outstanding Notes may declare the principal of the Notes and any accrued interest on the Notes to be due and payable by notice in writing to the Company and
the Trustee specifying the respective Event of Default and that it is a “notice of acceleration” (the “Acceleration Notice”) and the same shall become immediately due and payable. 

Upon such declaration of acceleration, the aggregate principal amount of, and accrued and unpaid interest and, if any, on all of the
outstanding Notes shall ipso facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any Holder of Notes. After such acceleration, but before a judgment or decree based on
acceleration, the Holders of a majority in aggregate principal amount of such outstanding Notes may, under certain circumstances, rescind and annul such acceleration if all Events of Default, other than the nonpayment of accelerated principal of or
interest on such Notes, have been cured or waived as provided in the Indenture. 

  
 A-12 

 In the event of any Event of Default specified in clause (4) above, such Event of Default
and all consequences thereof (excluding, however, any resulting payment default) will be annulled, waived and rescinded, automatically and without any action by the Trustee or the Holders of the Notes, if within 30 days after such Event of
Default arose the Company delivers an Officers’ Certificate to the Trustee stating that (x) the Indebtedness or guarantee that is the basis for such Event of Default has been discharged, (y) the holders thereof have rescinded or
waived the acceleration, notice or action (as the case may be) giving rise to such Event of Default or (z) the default that is the basis for such Event of Default has been cured, it being understood that in no event shall an acceleration of the
principal amount of the Notes as described above be annulled, waived or rescinded upon the happening of any such events. 
 If an Event of
Default specified in clause (7) above with respect to the Company occurs and is continuing, then all unpaid principal of, and premium, if any, and accrued and unpaid interest, if any, on all of the outstanding Notes shall ipso
facto become and be immediately due and payable without any declaration or other act on the part of the Trustee or any holder of the Notes. 

(14) Trustee Dealings with the Company. The Trustee, in its individual or any other capacity, may make loans to, accept deposits from,
and perform services for the Company, the Guarantors or their respective Affiliates, and may otherwise deal with the Company, the Guarantors or their respective Affiliates, as if it were not the Trustee. 

(15) No Recourse Against Others. No director, officer, employee, stockholder, unitholder, member, general or limited partner or
incorporator, past, present or future, of the Company, any of its Subsidiaries or any of its direct or indirect parent companies as such or in such capacity, shall have any personal liability for any obligations of the Company or any Guarantor under
the Notes, any Guarantee or the Indenture by reason of his, her or its status as such director, officer, employee, stockholder, unitholder, member, general or limited partner or incorporator. 

(16) Authentication. This Note shall not be valid until authenticated by the manual signature of the Trustee or an authenticating
agent. 
 (17) Abbreviations. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants
in common), TENENT (= tenants by the entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

(18) ISIN and/or Common Code Numbers. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification
Procedures, the Company has caused ISIN and/or Common Code numbers to be printed on the Notes and the Trustee may use ISIN and/or Common Code numbers in notices of redemption as a convenience to the Holders. No representation is made as to the
accuracy of such numbers either as printed on the Notes or as contained in any notice of redemption and reliance may be placed only on the other identification numbers placed thereon. 

The Company shall furnish to any Holder upon written request and without charge a copy of the Indenture. Requests may be made to: 

VWR Funding, Inc. 

Radnor Corporate Center 
 Building
One, Suite 200 
 100 Matsonford Road 

Radnor, Pennsylvania 19087 

Attention: Treasurer 

  
 A-13 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: (I) or (we) assign and transfer this Note to 

 
  
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  
  

 
  
  

 
  

(Print or type assignee’s name, address and zip code) 

and irrevocably appoint 
  

			
	 		
	to transfer this Note on the books of the Company. The agent may substitute another to act for him.		

  

									
	Date:		  
						
							Your Signature:		  

									(Sign exactly as your name appears on the face of this Note)

  

			
	Signature guarantee:		  

  

  
 A-14 

 OPTION OF HOLDER TO ELECT PURCHASE 

If you want to elect to have this Note purchased by the Company pursuant to Section 4.10 or 4.14 of the Indenture, check
the box below: 
 [    ] Section 4.10     [    ]
Section 4.14 
 If you want to elect to have only part of the Note purchased by the Company pursuant to Section 4.10
or Section 4.14 of the Indenture, state the amount you elect to have purchased: € 
  
  

									
	Date:		  
						
							Your Signature		  

									(Sign exactly as your name appears on the Note)

 Tax Identification No.: 

Signature guarantee: 

  
 A-15 

 CERTIFICATE TO BE DELIVERED UPON 

EXCHANGE OF TRANSFER RESTRICTED NOTES 
 VWR
Funding, Inc. 
 Radnor Corporate Center 
 Building One, Suite
200 
 100 Matsonford Road 
 Radnor, Pennsylvania 19087 

Attention: Treasurer 
 Law Debenture Trust Company of New York

 400 Madison Avenue, 4th Floor 
 New York, New York 10017 

Facsimile: (212) 750-1361 
 Attention: Corporate Trust
Services 
  

	 	Re:	Common Code/ISIN # 

 Reference is hereby made to that certain Indenture dated March 25,
2015 (the “Indenture”) by and among VWR Funding, Inc., a Delaware corporation (the “Company”), the Guarantors party thereto, DEUTSCHE BANK AG, LONDON BRANCH, as Paying Agent, DEUTSCHE BANK LUXEMBOURG S.A., as
Registrar and Transfer Agent, and LAW DEBENTURE TRUST COMPANY OF NEW YORK, as trustee (the “Trustee”). Capitalized terms used but not defined herein shall have the meanings set forth in the Indenture. 

This certificate relates to €         principal amount of Notes held in (check applicable space)
         book-entry or          definitive form by the undersigned. 

The undersigned          (transferor) (check one box below): 

 ̈ hereby requests the Registrar to deliver in exchange for its beneficial interest in the Global Note held by
the Common Depositary a Note or Notes in definitive, registered form of authorized denominations and an aggregate principal amount equal to its beneficial interest in such Global Note (or the portion thereof indicated above), in accordance with
Section 2.6 of the Indenture; 
  ̈ hereby requests the Trustee to exchange a Note or Notes to
        (transferee). 
 In connection with any transfer of any of the Notes evidenced by this
certificate occurring prior to the expiration of the two-year period after the Issue Date, the undersigned confirms that such Notes are being transferred in accordance with its terms: 

CHECK ONE BOX BELOW: 
 (1)     ̈     to the Company or any of its subsidiaries; or 
 (2)     ̈     inside the United States to a “qualified institutional buyer” (as defined in Rule 144A under the Securities Act of 1933, as amended) that purchases for its own
account or for the account of a qualified institutional buyer to whom notice is given that such transfer is being made in reliance on Rule 144A under the Securities Act of 1933, as amended, in each case pursuant to and in compliance with
Rule 144A thereunder; or 
 (3)      ̈     outside the United
States in an offshore transaction within the meaning of Regulation S under the Securities Act of 1933, as amended, in compliance with Rule 904 thereunder. 

  
 A-16 

 Unless one of the boxes is checked, the Registrar will refuse to register any of the Notes
evidenced by this certificate in the name of any person other than the registered holder thereof. 
  

	
	  

	Signature

  

					
	Signature Guarantee:		  
		
			(Signature must be guaranteed by a participant in a recognized signature guarantee medallion program)

 TO BE COMPLETED BY PURCHASER IF (2) ABOVE IS CHECKED. 

The undersigned represents and warrants that it is purchasing this Note for its own account or an account with respect to which it exercises
sole investment discretion and that it and any such account is a “qualified institutional buyer” within the meaning of Rule 144A under the Securities Act of 1933, as amended (“Rule 144A”), and is aware that the
sale to it is being made in reliance on Rule 144A and acknowledges that it has received such information regarding the Company as the undersigned has requested pursuant to Rule 144A or has determined not to request such information and
that it is aware that the transferor is relying upon the undersigned’s foregoing representations in order to claim the exemption from registration provided by Rule 144A. 

 

									
							[Name of Transferee]
				
							  

	Dated:		  
				NOTICE:		To be executed by an executive officer

  
 A-17 

 SCHEDULE OF EXCHANGES OF INTERESTS IN THIS GLOBAL NOTE 

The following exchanges of a part of this Global Note for other Notes have been made: 

 

									
	 Date of Exchange
	  	Amount of
Decrease in
Principal
Amount of this
Global Note	  	Amount of
Increase in
Principal
Amount of this
Global Note	  	Principal
Amount of this
Global Note
Following such
Decrease (or
Increase)	  	Signature of
Authorized
Officer of
Trustee of
Note Custodian
		  		  		  		  	
		  		  		  		  	
		  		  		  		  	

  
 A-18 

 EXHIBIT B 

FORM OF NOTATIONAL GUARANTEE 

The Guarantors listed below (hereinafter referred to as the “Guarantors,” which term includes any successors or assigns under
that certain Indenture, dated as of March 25, 2015 (as amended and supplemented from time to time, the “Indenture”), by and among VWR Funding, Inc., a Delaware corporation (the “Company”), the Guarantors party
thereto, the Paying Agent, the Registrar and Transfer Agent and the Trustee, have guaranteed the Notes and the obligations of the Company under the Indenture, which include (i) the due and punctual payment of the principal of, premium, if any,
and interest on the 4.625% Senior Notes due 2022 (the “Notes”) of the Company, whether at stated maturity, by acceleration or otherwise, the due and punctual payment of interest on the overdue principal and premium, if any, and (to
the extent permitted by law) interest on any interest, if any, on the Notes, and the due and punctual performance of all other obligations of the Company to the Holders or the Trustee all in accordance with the terms set forth in
Article XI of the Indenture, and (ii) in case of any extension of time of payment or renewal of any Notes or any such other obligations, that the same will be promptly paid in full when due or performed in accordance with the terms
of the extension or renewal, whether at stated maturity, by acceleration or otherwise. 
 The obligations of each Guarantor to the Holders
and to the Trustee pursuant to this Guarantee and the Indenture are expressly set forth in Article XI of the Indenture and reference is hereby made to such Indenture for the precise terms of this Guarantee. 

No stockholder, employee, officer, director, unitholder, member or incorporator, as such, past, present or future of each Guarantor shall have
any liability under this Guarantee by reason of his or its status as such stockholder, employee, officer, director, unitholder, member or incorporator. 

This is a continuing Guarantee and shall remain in full force and effect and shall be binding upon each Guarantor and its successors and
assigns until full and final payment of all of the Company’s obligations under the Notes and Indenture or until released in accordance with the Indenture and shall inure to the benefit of the successors and assigns of the Trustee and the
Holders, and, in the event of any transfer or assignment of rights by any Holder or the Trustee, the rights and privileges herein conferred upon that party shall automatically extend to and be vested in such transferee or assignee, all subject to
the terms and conditions hereof. This is a Guarantee of payment and not of collection. 
 This Guarantee shall not be valid or obligatory
for any purpose until the certificate of authentication on the Note upon which this Guarantee is noted shall have been executed by the Trustee under the Indenture by the manual signature of one of its authorized officers. The Obligations of each
Guarantor under its Guarantee shall be limited to the extent necessary to insure that it does not constitute a fraudulent conveyance under applicable law. 

THE TERMS OF ARTICLE XI OF THE INDENTURE ARE INCORPORATED HEREIN BY REFERENCE. 

  
 B-1 

 Capitalized terms used herein have the same meanings given in the Indenture unless otherwise
indicated. 
  
  

									
	Dated as of		  
						
				
							[Guarantor]
					
							By:		  

									Name:
									Title:

  
 B-2 

 EXHIBIT C 

[FORM OF CERTIFICATE TO BE DELIVERED 

IN CONNECTION WITH TRANSFERS PURSUANT TO RULE 144A] 

VWR Funding, Inc. 
 Radnor Corporate Center 

Building One, Suite 200 
 100 Matsonford Road 

Radnor, Pennsylvania 19087 
 Attention: Treasurer 

Law Debenture Trust Company of New York 
 400 Madison Avenue, 4th
Floor 
 New York, New York 10017 
 Facsimile:
(212) 750-1361 
 Attention: Corporate Trust Services 
  

	 	Re:	VWR Funding, Inc. (the “Company”) 4.625% Senior Notes due 2022 (the “Notes”) 

Ladies and Gentlemen: 
 In connection with our
proposed sale of €         aggregate principal amount at maturity of the Notes, we hereby certify that such transfer is being effected pursuant to and in accordance with Rule 144A
(“Rule 144A”) under the United States Securities Act of 1933, as amended (the “Securities Act”), and, accordingly, we hereby further certify that the Notes are being transferred to a person that we reasonably believe
is purchasing the Notes for its own account, or for one or more accounts with respect to which such person exercises sole investment discretion, and such person and each such account is a “qualified institutional buyer” within the meaning
of Rule 144A in a transaction meeting the requirements of Rule 144A and such Notes are being transferred in compliance with any applicable blue sky securities laws of any state of the United States. 

You and the Company are entitled to rely upon this letter and are irrevocably authorized to produce this letter or a copy hereof to any
interested party in any administrative or legal proceedings or official inquiry with respect to the matters covered hereby. 
  

			
	Very truly yours,
	
	  

	[Name of Transferor]
		
	By:		  

			Authorized Signature

  
 C-1 

 EXHIBIT D 

[FORM OF CERTIFICATE TO BE DELIVERED 

IN CONNECTION WITH TRANSFERS 

PURSUANT TO REGULATION S] 
 VWR Funding, Inc.

 Radnor Corporate Center 
 Building One, Suite 200 

100 Matsonford Road 
 Radnor, Pennsylvania 19087 

Attention: Treasurer 
 Law Debenture Trust Company of New York

 400 Madison Avenue, 4th Floor 
 New York, New York 10017 

Facsimile: (212) 750-1361 
 Attention: Corporate Trust
Services 
  

	 	Re:	VWR Funding, Inc. (the “Company”) 4.625% Senior Notes due 2022 (the “Notes”) 

Ladies and Gentlemen: 
 In connection with our
proposed sale of €         aggregate principal amount of the Notes, we confirm that such sale has been effected pursuant to and in accordance with Regulation S under the U.S. Securities Act of 1933,
as amended (the “Securities Act”), and, accordingly, we represent that: 
 (1) the offer of the Notes was
not made to a person in the United States; 
 (2) either (a) at the time the buy order was originated, the transferee
was outside the United States or we and any person acting on our behalf reasonably believed that the transferee was outside the United States or (b) the transaction was executed in, on or through the facilities of a designated off-shore
securities market and neither we nor any person acting on our behalf knows that the transaction has been pre-arranged with a buyer in the United States; 

(3) no directed selling efforts have been made in the United States in contravention of the requirements of Rule 903(b) or
Rule 904(b) of Regulation S, as applicable; and 
 (4) the transaction is not part of a plan or scheme to evade the
registration requirements of the Securities Act. 
 In addition, if the sale is made during a restricted period and the provisions of
Rule 903(b) or Rule 904(b) of Regulation S are applicable thereto, we confirm that such sale has been made in accordance with the applicable provisions of Rule 903(b) or Rule 904(b), as the case may be. 

  
 D-1 

 The Company and you are entitled to rely upon this letter and are irrevocably authorized to
produce this letter or a copy hereof to any interested party in any administrative or legal proceedings or official inquiry with respect to the matters covered hereby. Terms used in this certificate have the meanings set forth in Regulation S.

  

			
	Very truly yours,
	
	  

	[Name of Transferor]
		
	By:		  

			Authorized Signature

  
 D-2

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