Document:

EXHIBIT 10.23

                                    AMENDMENT
                                       TO
                          REGISTRATION RIGHTS AGREEMENT

      This AMENDMENT TO REGISTRATION RIGHTS AGREEMENT (this "Amendment") is made
and entered into effective as of December 31, 2005, by and among BIONOVO, INC.,
a Delaware corporation (formerly Lighten Up Enterprises International, Inc., a
Nevada corporation) ("Pubco"), and the other parties signatory hereto.

                                    RECITALS

      A. The parties hereto previously have entered into that certain
Registration Rights Agreement dated effective May 5, 2005, as amended by that
certain Acknowledgment and Amendment (such Registration Rights Agreement as so
amended, the "Original Agreement"), which Original Agreement provided for, among
other things, the mandatory registration (as more fully described in the
Original Agreement, the "Mandatory Registration") for resale of shares of common
stock of Pubco and shares of Pubco common stock underlying warrants (as more
fully described in the Original Agreement, the "Pubco Warrants") acquired by the
Purchasers (as defined in the Original Agreement) as of May 5, 2005 and
liquidated damages in the event such registration was not timely accomplished
and maintained (as more fully described in the Original Agreement, the
"Liquidated Damages");

      B. Pubco has registered such shares of Pubco common stock on a
registration statement on Form SB-2 (File No. 333-126399, the "Effective
Registration Statement"), declared effective by the Securities and Exchange
Commission ("SEC") on November 2, 2005;

      C. As a consequence of the Mandatory Registration obligations and
Liquidated Damages provisions, Pubco has been required under Generally Accepted
Accounting Principles to record a liability on its balance sheet relating to the
Pubco Warrants and an expense on its statement of operations reflecting the
change in fair value of such warrant liability;

      D. It is the belief of Pubco's management that such warrant liability and
expense relating to the Mandatory Registration obligation and Liquidated Damages
provisions limits Pubco's opportunity to be listed on either the American Stock
Exchange or the NASDAQ SmallCap Market; and

      E. In order to permit Pubco to reclassify the accounting treatment of the
Pubco Warrants to additional paid in capital and thereby remove the
above-referenced warrant liability and expense from its balance sheet and
statement of operations, the parties hereto agree to amend the Original
Agreement to delete the Mandatory Registration obligation and the Liquidated
Damages provisions and in partial consideration therefor grant "piggy-back"
registration rights to the Holders, all upon the terms and conditions of this
Amendment;

      NOW, THEREFORE, in consideration of the foregoing and of the mutual
promises and covenants hereinafter set forth and of other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties agree as follows:

      SECTION 1. Defined Terms. Capitalized terms used in this Amendment but not
otherwise defined herein shall have the meanings ascribed to them in the
Original Agreement.
<PAGE>

      SECTION 2. Amendments.

            (a) The obligation of Pubco to register the Registrable Securities
pursuant to Section 2(a) of the Original Agreement is hereby amended to delete
such obligation of Pubco;

            (b) The Original Agreement is hereby amended to delete Section 2(b)
(Filing Default Liquidation Damages) and Section 2(c) (Effectiveness Default
Liquidation Damages) of the Original Agreement.

            (c) Notwithstanding the foregoing amendments, Pubco agrees to use
its commercially reasonable best efforts to maintain the effectiveness of the
Effective Registration Statement for the period specified in the Original
Agreement and the Holders shall remain obligated to satisfy their respective
obligations under the Original Agreement relating to the Effective Registration
Statement.

            (d) The Original Agreement is hereby amended to add the following
two subsections to Section 2 of the Original Agreement:

                  "(g) "Piggy-Back" Registration. If (but without any obligation
      to do so) Pubco proposes to register (including for this purpose a
      registration effected by Pubco for stockholders other than the Holders)
      any of its stock or other securities under the Securities Act in
      connection with the public offering of such securities solely for cash
      (other than a registration relating solely to the sale of securities to
      participants in Pubco stock plan, a registration with respect solely to a
      corporate reorganization or other transaction under Rule 145 of the
      Securities Act, a registration on any form which does not include
      substantially the same information as would be required to be included in
      a registration statement covering the sale of the Registrable Securities,
      or a registration in which the only Pubco Stock being registered is Pubco
      Stock issuable upon exercise of debt securities which are also being
      registered), Pubco shall, at such time, promptly give each Holder written
      notice of such registration. Upon the written request of each Holder given
      within twenty (20) days after mailing of such notice by Pubco, Pubco
      shall, subject to the provisions of Section 2(h), cause to be registered
      under the Securities Act all of the Registrable Securities that each such
      Holder has requested to be registered. The registration rights granted to
      a Holder pursuant to this paragraph shall terminate with respect to such
      Holder on the date when all of the Registrable Securities of such Holder
      covered by the Effective Registration Statement or an effective
      registration statement under this paragraph (a) have been sold pursuant to
      the Effective Registration Statement or such other registration statement
      or an exemption from the registration requirements of the Securities Act
      or (b) may be sold without any volume or other restrictions pursuant to
      Rule 144(k).

                  (h) Underwriting Requirements. In connection with any
      registered offering under Section 2 hereof involving an underwriting of
      shares of Pubco's capital stock, Pubco shall not be required to include
      any of the Holders' Registrable Securities in such underwriting unless
      they accept the terms of the underwriting as agreed upon between Pubco and
      the underwriters selected by it (or by other persons entitled to select
      the underwriters), and then only in such quantity as the underwriters
      determine in their sole discretion will not jeopardize the success of the
      offering by Pubco. If the total amount of securities, including
      Registrable Securities, requested by stockholders to be included in such
      offering exceeds the amount of securities that may be sold other than by
      Pubco that the underwriters determine in their sole discretion is

                                       2
<PAGE>

      compatible with the success of the offering, then Pubco shall be required
      to include in the offering only that number of such securities, including
      Registrable Securities, which the underwriters determine in their sole
      discretion will not jeopardize the success of the offering (the securities
      so included to be apportioned pro rata among the selling stockholders
      according to the total amount of securities entitled to be included
      therein owned by each selling stockholder or in such other proportions as
      shall mutually be agreed to by such selling stockholders, provided,
      however, that with respect to Pubco's IPO (defined below), all Registrable
      Securities may be excluded). For purposes of the preceding parenthetical
      concerning apportionment, for any selling stockholder which is a Holder of
      Registrable Securities and which is a partnership or corporation, the
      partners, retired partners and stockholders of such Holder, or the estates
      and family members of any such partners and retired partners and any
      trusts for the benefit of any of the foregoing persons shall be deemed to
      be a single "selling stockholder", and any pro-rata reduction with respect
      to such "selling stockholder" shall be based upon the aggregate amount of
      shares carrying registration rights owned by all entities and individuals
      included in such "selling stockholder", as defined in this sentence. The
      term "IPO" means the first underwritten public offering of Pubco's Stock
      registered under the Securities Act, other than a registration relating
      solely to a transaction under Rule 145 under the Securities Act or to an
      employee benefit plan of Pubco."

      SECTION 3. Effectiveness of Amendments. In accordance with Section 6(d) of
the Original Agreement, this Amendment shall not be effective unless and until
executed by Pubco and the Holders of at least sixty-six percent (66%) of the
outstanding Registrable Securities (assuming the exercise of all Pubco Warrants,
whether exercised or not).

      SECTION 4. Representations and Warranties.

            (a) Each of the undersigned parties (other than Pubco) hereby
affirms and remakes to Pubco all of the representations and warranties set forth
in the Subscription Agreement and in the Investor Questionnaire executed by such
party as of May 5, 2005.

            (b) Without limiting the generality of the foregoing, each of the
undersigned parties (other than Pubco) hereby represents and warrants to Pubco
that he, she or it is an "accredited investor" as that term is defined in Rule
501 of Regulation D promulgated under the Securities Act.

            (c) Each of the undersigned parties (other than Pubco) hereby
represents and warrants to Pubco that such party has read Pubco's Form SB-2 (SEC
File No. 333-126399), declared effective by the SEC on November 2, 2005, and the
prospectus contained therein as supplemented by Prospectus Supplement No. 1
dated November 14, 2005 and Prospectus Supplement No. 2 dated January 6, 2006,
and has been given the opportunity to ask any questions of and receive answers
from Pubco with respect thereto.

      SECTION 5. Ratification of Original Agreement. Except as modified by the
terms of this Amendment, the Original Agreement is hereby ratified and confirmed
in its entirety, and shall remain in full force and effect in accordance with
its terms.

      SECTION 6. Counterparts. This Amendment may be executed in one or more
counterparts, each of which shall be deemed an original, but all of which
together shall constitute one and the same instrument. Each party hereto
confirms that any facsimile copy of such party's executed counterpart of this
Amendment (or its signature page thereof) shall be deemed to be an executed copy
thereof.

                                       3
<PAGE>

      SECTION 7. Governing Law. This Amendment shall be governed by the laws of
the State of California (other than its rules of conflicts of law to the extent
that the application of the laws of another jurisdiction would be required
thereby).

      SECTION 8. Counsel. EACH OF THE UNDERSIGNED PARTIES ACKNOWLEDGES THAT HE,
SHE OR IT HAS BEEN ADVISED TO CONSULT SUCH PARTY'S LEGAL AND FINANCIAL ADVISORS
WITH RESPECT TO THE TERMS AND CONDITIONS OF THIS AMENDMENT AND HAS BEEN GIVEN
THE OPPORTUNITY TO DO SO.

      SECTION 9. Entire Agreement. The Original Agreement (including any and all
annexes, exhibits and schedules thereto), as amended by this Amendment,
constitute the entire agreement of the parties hereto with respect to the
subject matter thereof and hereof, and supersede all prior agreements and
understandings of the parties, oral and written, with respect to the subject
matter thereof and hereof.

      SECTION 10. Other General. The recitals hereto are a material part hereof
and are incorporated in this Amendment by reference as if fully set forth
herein. Captions and headings are for convenience only, are not deemed to be
part of this Amendment and shall not be used in the interpretation of this
Amendment.

                               [Signatures follow]

                                       4
<PAGE>

      IN WITNESS WHEREOF, the parties have executed this Amendment to
Registration Rights Agreement effective as of the date first set forth above.

                                  PUBCO:

                                  BIONOVO, INC.
                                  (a Delaware corporation)

                                  By:_____________________________
                                  Name:___________________________
                                  Title:__________________________

                                       5
<PAGE>

      IN WITNESS WHEREOF, the parties have executed this Amendment to
Registration Rights Agreement effective as of the date first set forth above.

                                  HOLDER:

                                  If Holder is an Entity:

                                  ______________________________________________
                                  Print Name of Entity

                                  By (signature):_______________________________
                                  Name (print):_________________________________
                                  Title:________________________________________

                                  If Holder(s) is an Individual(s):

                                  Signature:____________________________________
                                  Print Name:___________________________________

                                  Signature:____________________________________
                                  Print Name:___________________________________

                                       6[FORM OF] CONVERTIBLE NOTE

    THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
    UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES  ACT") OR
    APPLICABLE STATE SECURITIES LAWS, AND, ACCORDINGLY,  MAY NOT BE OFFERED
    OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH
    SECURITIES  UNDER THE SECURITIES ACT AND  APPLICABLE  STATE  SECURITIES
    LAWS OR PURSUANT TO AN OPINION OF COUNSEL  REASONABLY  SATISFACTORY  TO
    THE COMPANY THAT THERE IS AN AVAILABLE  EXEMPTION FROM THE REGISTRATION
    REQUIREMENTS OF THE SECURITIES ACT.

Principal Amount: $XXX.XX                                     Irvine, California
                                                             Date: March 1, 2006

      FOR VALUE RECEIVED, NUWAY MEDICAL, INC., a corporation organized under the
laws of the  state of  Delaware  ("Borrower"),  promises  to pay to the order of
"Investor",  as  that  term is  defined  below  (hereafter,  together  with  any
subsequent  holder  hereof,  called  "Holder"),  at its  office  at  "Investor's
Address",  as that term is defined  below,  or at such other place as Holder may
direct, the "Principal Amount", noted above (the "Loan"), payable on January 31,
2007,  or at an earlier  date as provided  herein (the  "Maturity  Date").  This
Convertible Note is duly authorized issue of the Borrower (the "Issuer"), issued
on March 1, 2006 (the "Issuance  Date"),  and designated as its Convertible Note
due January 31, 2007 (the "Note").

      The Borrower agrees to pay interest on the unpaid  principal amount of the
Loan from time to time  outstanding  hereunder at the following  rates per year,
compounded annually: (i) before maturity of the Loan, whether by acceleration or
otherwise,  at the rate per annum  equal to ten  percent  (10%);  (ii) after the
maturity of the Loan,  whether by  acceleration  or otherwise,  until paid, at a
rate per annum equal to fifteen percent (15%).

      Payments of both  principal  and  interest  are to be made in  immediately
available  funds in lawful money of the United  States of America,  or in Common
Stock of the Borrower as set forth below.

      Accrual of interest shall commence as of the Issuance Date. Interest shall
be payable by the Issuer,  at the Issuer's option,  in cash or in that number of
shares of Common stock of the Issuer (the "Common  Stock") (at a price per share
calculated pursuant to the conversion formula contained below), upon the earlier
to occur of (i) upon conversion of this Note pursuant to the conversion features
set forth below,  or (ii) upon an Event of Default as defined  below,  and if an
Event of Default occurs interest due hereunder shall be payable in cash or stock
as set forth  herein at the option of the  Holder.  Unless  otherwise  agreed in
writing by both  parties  hereto,  the  interest so payable  will be paid to the
person in whose name this Note (or one or more predecessor  Notes) is registered
on the records of the Issuer  regarding  registration  and transfers of the Note
(the "Note  Register"),  provided,  however,  that the Issuer's  obligation to a
transferee of this Note arises only if such transfer,  sale or other disposition
is made in accordance  with the terms and conditions  contained in the Agreement
and this Note.

      The Note is subject to the following additional provisions:

<PAGE>

      1. The Issuer shall be entitled to withhold from all payments of principal
and/or  interest  of this Note any amounts  required  to be  withheld  under the
applicable  provisions of the U.S. Internal Revenue Code of 1986, as amended, or
other applicable laws at the time of such payments.

      2. This Note has been issued subject to investment  representations of the
original  Holder hereof and may be  transferred  or exchanged only in compliance
with the Securities Act and applicable  state  securities laws and in compliance
with the  restrictions on transfer  provided in the Agreement.  Prior to the due
presentment  for such  transfer  of this  Note,  the Issuer and any agent of the
Issuer may treat the person in whose  name this Note is duly  registered  on the
Issuer's Note register as the owner hereof for the purpose of receiving  payment
as herein provided and all other purposes,  whether or not this Note is overdue,
and  neither  the Issuer nor any such agent  shall be  affected by notice to the
contrary.  The  transferee  shall be bound,  as the original  Holder by the same
representations and terms described herein and under the Agreement.

      3. The Holder or Issuer  may, at its  option,  subject to the  "Conversion
Contingencies"  (set forth below),  at any time convert the principal  amount of
this Note or any portion  thereof,  and any  accrued  interest  thereon,  into a
number  shares  of fully  paid and non  assessable  Common  Stock of the  Issuer
pursuant  to the  following  formula:  the  Principal  Amount  divided by $0.025
("Conversion  Shares").  The  right to  convert  the Note  may be  exercised  by
telecopying  an executed  and  completed  notice of  conversion  (the "Notice of
Conversion")  to the Holder or Issuer.  Each  business  day on which a Notice of
Conversion  is  telecopied in  accordance  with the  provisions  hereof shall be
deemed  a  "Conversion   Date".   The  Issuer  will  transmit  the  certificates
representing  Conversion  Shares  issuable  upon  such  conversion  of the  Note
(together with the  certificates  representing the Note not so converted) to the
Holder via express courier,  by electronic transfer (if applicable) or otherwise
within ten Business Days after the  Conversion  Date,  provided,  the Issuer has
received the original  Note being so converted  from the Holder.  If the Company
has not received the original Note being  converted  within three  Business Days
after   Conversion  Date,  then  the  Issuer  shall  transmit  the  certificates
representing  the Conversion  Shares  issuable upon such  conversion of the Note
(together with the  certificates  representing the Note not so converted) to the
Holder via express courier,  by electronic transfer (if applicable) or otherwise
within five business days after receipt of the original Notice of Conversion and
original Note being converted.  The Conversion of this note may require that the
Issuer amend its charter to increase the number of common shares  authorized and
therefore, the conversion may not take place prior to the Issuer's completion of
that  process.  Any  delay  due to such  circumstance  shall  not be an event of
default  under this Note.  Issuer  shall  promptly  take  action to affect  such
amendments to its charter.

      4. Conversion  Contingencies:  Notwithstanding anything else herein to the
contrary,  the Holder shall not have the right,  and the Company  shall not have
the  obligation,  to convert all or any  portion of this Note,  unless and until
each of the following events has first occurred:  (i) the Company's stockholders
have approved an increase in the number of shares of common stock  authorized by
the Company's Certificate of Incorporation in an amount not less than the amount
required  to permit all  warrants  issued in this  series to be  converted  into
shares of the  Company's  Common  Stock as provided  herein,  at a validly  held
meeting of stockholders at which a quorum is present and acting throughout;  and
(ii) the  Company has filed with the  Secretary  of State of State of Delaware a
Certificate of Amendment to the Company's  Certificate of Incorporation to amend
its  Certificate  of  Incorporation  to increase  the number of shares of common
stock authorized by the Company's Certificate of Incorporation.

                                      -2-
<PAGE>

      5. The principal  amount of this Note, and any accrued  interest  thereon,
shall be  reduced  as per that  principal  amount  indicated  on the  Notice  of
Conversion upon the proper receipt by the Holder of such  Conversion  Shares due
upon such Notice of Conversion.

      6. The number of Conversion Shares shall be adjusted as follows:

            a. If the Issuer shall at any time subdivide its outstanding  shares
      of Common  Stock  into a greater  number  of shares of Common  Stock,  the
      number  of  Conversion   Shares  in  effect   immediately  prior  to  such
      subdivision shall be proportionately  increased,  and conversely,  in case
      the  outstanding  shares of Common Stock shall be combined  into a smaller
      number  of  shares  of  Common  Stock,  the  Conversion  Price  in  effect
      immediately prior to such combination shall be proportionately reduced.

      7. No provision of this Note shall alter or impair the  obligation  of the
Issuer,  which is  absolute  and  unconditional,  upon an Event of  Default  (as
defined below), to pay the principal of, and interest on this Note at the place,
time, and rate, and in the coin or currency herein prescribed.

      8. Events Of Default.  Each of the following occurrences is hereby defined
as an "Event of Default":

            a.  Nonpayment.  The  Borrower  shall  fail to make any  payment  of
      principal,  interest,  or other amounts payable hereunder when and as due;
      or

            b.  Dissolutions,  etc. The Borrower or any subsidiary shall fail to
      comply with any  provision  concerning  its  existence or any  prohibition
      against dissolution, liquidation, merger, consolidation or sale of assets;
      or

            c.  Noncompliance  with this  Agreement.  The Borrower shall fail to
      comply in any material  respect with any provision  hereof,  which failure
      does not otherwise  constitute an Event of Default, and such failure shall
      continue for ten (10) days after the occurrence of such failure; or

            d.   Bankruptcy.   Any   bankruptcy,   insolvency,   reorganization,
      arrangement,   readjustment,    liquidation,   dissolution,   or   similar
      proceeding,  domestic or foreign, is instituted by or against the Borrower
      or any of its  subsidiaries,  or the  Borrower or any of its  subsidiaries
      shall take any step toward, or to authorize, such a proceeding; or

            e. Insolvency.  The Borrower shall make a general assignment for the
      benefit of its  creditors,  shall  enter into any  composition  or similar
      agreement,  or  shall  suspend  the  transaction  of all or a  substantial
      portion of its usual business.

      9. If one or more "Events of Default"  shall occur,  then,  or at any time
thereafter,  and in each and every such case, unless such Event of Default shall
have been waived in writing by the Holder  (which  waiver shall not be deemed to
be a waiver of any  subsequent  default)  or cured as  provided  herein,  at the
option of the Holder, and in the Holder's sole discretion,  the Holder may elect
to consider this Note (and all interest  through such date)  immediately due and
payable.  In order to so elect,  the Holder must deliver  written  notice of the
election and the amount due to the Borrower via certified  mail,  return receipt
requested,  at the Borrower's  address as set forth herein (or any other address
provided to the Holder),  and  thereafter  the Borrower  shall have ten business
days upon  receipt to cure the Event of  Default,  pay the Note,  or convert the
amount due on the Note pursuant to the conversion formula set forth above. It is
agreed  that in the event of such  action,  such  Holder  shall be  entitled  to

                                      -3-
<PAGE>

receive all reasonable  fees,  costs and expenses  incurred,  including  without
limitation  such  reasonable  fees  and  expenses  of  attorneys.   The  parties
acknowledge  that a change in control of the Issuer shall not be deemed to be an
Event of Default as set forth herein.

      10. In case any  provision  of this  Note is held by a court of  competent
jurisdiction  to be excessive in scope or  otherwise  invalid or  unenforceable,
such provision shall be adjusted rather than voided, if possible,  so that it is
enforceable to the maximum extent possible,  and the validity and enforceability
of the  remaining  provisions  of this Note will not in any way be  affected  or
impaired thereby.

      11. This Note does not entitle the Holder  hereof to any voting  rights or
other rights as a stockholder of the Issuer prior to the conversion  into Common
Stock thereof, except as provided by applicable law. If, however, at the time of
the surrender of this Note and conversion the Holder hereof shall be entitled to
convert this Note, the Conversion  Shares so issued shall be and be deemed to be
issued to such  holder  as the  record  owner of such  shares as of the close of
business on the Conversion Date.

      12. The Borrower,  in its sole and absolute discretion,  may elect, at any
time and from  time to time,  to  prepay  all or some of the  principal  of,  or
accrued interest on, the Note,  without  penalty,  prior to the Maturity Date (a
"Prepayment");  provided,  however, that the Borrower may not elect a Prepayment
until the  conversion  contingencies  specified  in  Paragraph 4 above have been
removed.  In the event of a Prepayment,  the Borrower  shall give written notice
(the "Prepayment  Notice") not less than 15 days prior to the Prepayment to each
Holder.  Notwithstanding  anything  contained  herein to the contrary,  a Holder
shall have the sole and absolute right, within 10 days following the date of the
Prepayment  Notice, to elect to convert the Note into Conversion Shares pursuant
to Paragraph 3 above,  by executing and delivering to the Borrower the Notice of
Conversion. If the Holder has not delivered to the Borrower a copy of the Notice
of Conversion by the date referred to in the previous sentence, the Holder shall
be deemed  irrevocably to have consented to the Prepayment and shall  thereafter
not be entitled to receive any Conversion Shares to the extent of the Prepayment
specified in the Prepayment  Notice. The calculation of the number of Conversion
Shares  subject  to any such  election  by the  Holder  shall be  subject to the
applicable  provisions of this Note,  including without  limitation  Paragraph 6
above.

      IN WITNESS WHEREOF, the Issuer has caused this Note to be duly executed by
an officer thereunto duly authorized.

NUWAY MEDICAL, INC.                ACKNOWLEDGED AND ACCEPTED:

                                   Investor Name (print):
By /s/                                                   -----------------------
  -------------------
Name: Dennis Calvert,
      its President

                                   Investor Signature:
                                                      --------------------------

                                   Address:
                                                  ------------------------------

                                                  ------------------------------

                                      -4-
<PAGE>

                              NOTICE OF CONVERSION

      (To be Executed by the Registered Holder in order to Convert the Note)

      The undersigned hereby  irrevocably  elects to convert  ___________ of the
principal  amount of the above Note into  ___________  Shares of Common Stock of
NuWay Medical,  Inc.  according to the conditions hereof, as of the date written
below.

Date of Conversion:
                    ---------------------------------

Signature:
           ------------------------------------------

Name:
     ------------------------------------------------

Address:
        ------------------------------------

        ------------------------------------

Date of Conversion:
                    ---------------------------------

Signature:
           ------------------------------------------

Name:
     ------------------------------------------------

Address:
        ------------------------------------

        ------------------------------------

                                      -1-

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