Document:

EX-4.2

 Exhibit 4.2 

SUPPLEMENTAL INDENTURE ESTABLISHING A SERIES OF 

EURO-DENOMINATED NOTES 
 WMG
ACQUISITION CORP. 
 as Issuer 

and 
 the Subsidiary Guarantors
from time to time party to the Indenture 
 and 

WELLS FARGO BANK, NATIONAL ASSOCIATION 

as Trustee 
  

 
 FIFTH
SUPPLEMENTAL INDENTURE 
 DATED AS OF AUGUST 16, 2021 

to the 
 INDENTURE 

DATED AS OF JUNE 29, 2020 

Providing for the Issuance of 

2.250% Senior Secured Notes Due 2031 
  

 FIFTH SUPPLEMENTAL INDENTURE, dated as of August 16, 2021 (this “Supplemental
Indenture”), among WMG Acquisition Corp. (together with its successors and assigns, the “Company”), as issuer, the Subsidiary Guarantors under the Indenture referred to below (the “Subsidiary Guarantors”),
and Wells Fargo Bank, National Association, as Trustee. 
 W I T N E S S E T H: 

WHEREAS, the Company, the Subsidiary Guarantors, the Trustee, the Notes Authorized Representative and the Collateral Agent are party to the
Indenture, dated as of June 29, 2020 (as amended, supplemented, waived or otherwise modified from time to time, the “Indenture”), which provides for the issuance from time to time of Notes by the Company; 

WHEREAS, Section 9.01(8) of the Indenture provides that the Company may provide for the issuance of Additional Notes in accordance with
the limitations set forth in the Indenture as of the Closing Date; 
 WHEREAS, in connection with the issuance of the 2031 Euro Notes (as
defined herein), the Company has duly authorized the execution and delivery of this Supplemental Indenture to establish the forms and terms of the 2031 Euro Notes as hereinafter described; and 

WHEREAS, pursuant to Section 9.01 of the Indenture, the parties hereto are authorized to execute and deliver this Supplemental Indenture
to amend the Indenture, without the consent of any Holder; 
 NOW, THEREFORE, in consideration of the foregoing and for other good and
valuable consideration, the receipt of which is hereby acknowledged, the Company, the Subsidiary Guarantors and the Trustee mutually covenant and agree for the benefit of the Holders as follows: 

1. Capitalized Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture. 

2. Title of Notes. There shall be a series of Notes of the Company designated the “2.250% Senior Secured Notes due 2031” (the
“2031 Euro Notes”), which Notes shall be Euro-denominated. 
 3. Maturity Date. The Maturity Date of the 2031 Euro
Notes shall be August 15, 2031. 

  
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 4. Interest and Interest Rates. Interest on the outstanding principal amount of 2031
Euro Notes will accrue at the rate of 2.250% per annum and will be payable semi-annually in arrears on February 15 and August 15 in each year, commencing on February 15, 2022, to holders of record on the immediately preceding
February 1 and August 1, respectively (each such February 1 and August 1, a “Record Date”). Interest on the 2031 Euro Notes will accrue from the most recent date to which interest has been paid or provided for
or, if no interest has been paid, from August 16, 2021, except that interest on any Additional 2031 Euro Notes (as defined below) issued on or after the first Interest Payment Date (and Exchange Notes issued in exchange therefor) will accrue
(or will be deemed to have accrued) from the most recent date to which interest has been paid or duly provided for or, if no interest has been paid, from August 16, 2021 (or if the date of issuance of such Additional 2031 Euro Notes is an
Interest Payment Date, from such date of issuance); provided that if any 2031 Euro Note and any Exchange Notes issued in exchange therefor are surrendered for exchange on or after a record date for an Interest Payment Date that will occur on or
after the date of such exchange, interest on such Note received in exchange thereof will accrue from such Interest Payment Date. 
 5. No
Limitation on Aggregate Principal Amount. The aggregate principal amount of 2031 Euro Notes that may be authenticated and delivered and outstanding under the Indenture is not limited. The aggregate principal amount of the 2031 Euro Notes shall
initially be €445 million. The Company may from time to time, without the consent of the Holders, create and issue Additional Notes having the same terms and conditions as the 2031 Euro Notes in all respects or in all respects except for
issue date, issue price and, if applicable, the first date on which interest accrues and the first payment of interest thereon. Additional Notes issued in this manner will be consolidated with, and will form a single series with, the 2031 Euro Notes
(any such Additional Notes, “Additional 2031 Euro Notes”), unless otherwise specified for Additional Notes in an applicable Notes Supplemental Indenture, or otherwise designated by the Company, as contemplated by Section 2.01
of the Indenture. 
 6. Redemption. (a) The 2031 Euro Notes may be redeemed, in whole or in part, at any time prior to
August 15, 2026, at the option of the Company, at a redemption price equal to 100% of the principal amount of the 2031 Euro Notes redeemed plus the Applicable Premium as of, and accrued and unpaid interest, if any, to, the applicable Redemption
Date (subject to the right of Holders on the relevant Record Date to receive interest due on the relevant interest payment date). 

“Applicable Premium” means, with respect to any 2031 Euro Note on any applicable Redemption Date, the greater of: 

(1) 1.0% of the then outstanding principal amount of such 2031 Euro Note; and 

(2) the excess, if any, of: 

  
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 (a) the present value at such redemption date of (i) the redemption price of
the 2031 Euro Note at August 15, 2026 (such redemption price being set forth in the table appearing in Section 6(b)) plus (ii) all required remaining scheduled interest payments due on the 2031 Euro Note through August 15,
2026 (excluding accrued but unpaid interest to such redemption date), computed using a discount rate equal to the Bund Rate as of such redemption date plus 75.0 basis points; over 

(b) the then outstanding principal amount of the 2031 Euro Note. 

“Bund Rate” means, as of the applicable redemption date, the yield to maturity as of such redemption date of direct
obligations of the Federal Republic of Germany (Bunds or Bundesanleihen) with a constant maturity (as officially compiled and published in the most recent financial statistics that have become publicly available at least two business days (but not
more than five business days) prior to such redemption date (or, if such financial statistics are not so published or available, any publicly available source of similar market data selected by the Company in good faith)) most nearly equal to the
period from such redemption date to August 15, 2026; provided, however, that if the period from such redemption date to August 15, 2026 is not equal to the constant maturity of the direct obligation of the Federal Republic of Germany for
which a weekly average yield is given, the Bund Rate shall be obtained by linear interpolation (calculated to the nearest one-twelfth of a year) from the weekly average yields of direct obligations of the
Federal Republic of Germany for which such yields are given, except that if the period from such redemption date to August 15, 2026 is less than one year, the weekly average yield on actually traded direct obligations of the Federal Republic of
Germany adjusted to a constant maturity of one year shall be used; provided that if the Bund Rate determined in accordance with the foregoing shall be less than zero, the Bund Rate shall be deemed to be zero for all purposes of the Indenture. 

(b) On or after August 15, 2026, the Company may redeem all or a part of the 2031 Euro Notes, at its option, at the redemption prices
(expressed as percentages of principal amount) set forth below plus accrued and unpaid interest, if any, on the 2031 Euro Notes to be redeemed to the applicable Redemption Date, if redeemed during the twelve-month period beginning on August 15
of the years indicated below: 
  

					
	Year	  	Percentage	 
	 2026
	  	 	101.125	% 
	 2027
	  	 	100.563	% 
	 2028 and thereafter
	  	 	100.000	% 

  

  
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 (c) At any time prior to August 15, 2026, the Company may on any one or more occasions
redeem up to 40% of the aggregate principal amount of 2031 Euro Notes (including the aggregate principal amount of any Additional 2031 Euro Notes) issued under the Indenture, at its option, at a redemption price equal to 102.250% of the principal
amount of the 2031 Euro Notes redeemed, plus accrued and unpaid interest thereon, if any, to the date of redemption (subject to the rights of Holders on the relevant Record Date to receive interest on the relevant interest payment date) (each, a
“Note Equity Offering Redemption”), with funds in an aggregate amount not exceeding the net cash proceeds of one or more Equity Offerings by the Company or any contribution to the Company’s common equity capital made with the
net cash proceeds of one or more Equity Offerings by the Company’s direct or indirect parent; provided that: 
 (i) at least 50%
of the aggregate principal amount of 2031 Euro Notes originally issued under the Indenture (including the aggregate principal amount of any Additional 2031 Euro Notes) remains outstanding immediately after the occurrence of such redemption (unless
all such 2031 Euro Notes are otherwise repurchased or redeemed substantially concurrently with the corresponding Note Equity Offering Redemption); and 

(ii) notice of such redemption is given no more than 180 days after the date of, and may be conditioned upon, the closing of such Equity
Offering. 
 (d) In addition, during any twelve-month period prior to August 15, 2026, the Company may redeem up to 10% of the original
aggregate principal amount of the 2031 Euro Notes (including the principal amount of any Additional 2031 Euro Notes) at a redemption price equal to 101.125% of the aggregate principal amount thereof, plus accrued and unpaid interest thereon, if any,
to the Redemption Date (subject to the right of Holders of record on the relevant Record Date to receive interest due on the relevant Interest Payment Date). 

(e) The Company may acquire 2031 Euro Notes by means other than a redemption, whether by tender offer, open market purchases, negotiated
transactions or otherwise, in accordance with applicable securities laws, so long as such acquisition does not otherwise violate the terms of the Indenture. 

(f) Any redemption or notice of any redemption may, at the Company’s discretion, be subject to one or more conditions precedent,
including, but not limited to, completion of an Equity Offering, other offering or other corporate transactions or event. Notice of any redemption in respect of an Equity Offering may be given prior to the completion thereof. 

7. Modifications to Indenture. The following terms of the Indenture are hereby amended solely with respect to the 2031 Euro Notes and
not with respect to any Original Notes or Additional Notes other than the 2031 Euro Notes as follows: 
 (a) Section 1.01 is amended by
replacing clause (26) of the definition of “Permitted Liens” with the following: 

  
 5 

 (26) Liens securing (i) First Lien Indebtedness in an aggregate principal amount (as of
the date of incurrence of any such Indebtedness and after giving pro forma effect to the incurrence thereof and the application of the net proceeds therefrom (or as of the date of the initial borrowing of such Indebtedness after giving pro
forma effect to the incurrence of the entire committed amount of such Indebtedness)), not exceeding the greater of (A) $3,600 million and (B) the maximum aggregate principal amount of First Lien Indebtedness that could be incurred
without exceeding a First Lien Indebtedness to EBITDA Ratio for the Issuer of 4.50 to 1.00, (ii) Senior Secured Indebtedness that is not First Lien Indebtedness in an aggregate principal amount (as of the date of incurrence of any such Indebtedness
and after giving pro forma effect to the incurrence thereof and the application of the net proceeds therefrom (or as of the date of the initial borrowing of such Indebtedness after giving pro forma effect to the incurrence of the entire committed
amount of such Indebtedness)) not exceeding the maximum aggregate principal amount of Senior Secured Indebtedness that could be incurred without exceeding a Senior Secured Indebtedness to EBITDA Ratio for the Issuer of 5.00 to 1.00, (iii) Revolving
Credit Agreement Indebtedness not to exceed at any time outstanding the greater of $400 million and 50% of EBITDA (for the Measurement Period applicable at the time such Revolving Credit Agreement Indebtedness is committed) and
(iv) Indebtedness in an amount not to exceed the greater of $450 million and 60.0% of EBITDA (for the Measurement Period applicable at the time of the incurrence of such Indebtedness) pursuant to Section 2.6 of the Senior Term Loan
Agreement as in effect on January 31, 2018; 
 8. Form. The 2031 Euro Notes shall be issued substantially in the form set forth,
or referenced, in Article Two of the Indenture, and Exhibit A-2 or Exhibit C-2 attached to the Indenture, in each case as provided for in Section 2.02 of the
Indenture (as such form may be modified in accordance with Section 2.01 of the Indenture). 
 9. Governing Law. THE INTERNAL LAW
OF THE STATE OF NEW YORK SHALL GOVERN AND BE USED TO CONSTRUE THIS SUPPLEMENTAL INDENTURE WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED
THEREBY. 
 10. Ratification of Indenture; Supplemental Indentures Part of Indenture. Except as expressly amended hereby, the
Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder
heretofore or hereafter authenticated and delivered shall be bound hereby. The Trustee makes no representation or warranty as to the validity or sufficiency of this Supplemental Indenture or as to the accuracy of the recitals to this Supplemental
Indenture. 

  
 6 

 11. Counterparts. The parties may sign any number of copies of this Supplemental
Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 
 12. Effect of Headings.
The Section headings herein are for convenience only and shall not affect the construction hereof. 
 13. Electronic Execution of
Documents. The words “execution”, “signed”, “signature”, and words of like import in any amendment, supplement or other modification hereof (including waivers and consents) shall be deemed to include electronic
signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity or enforceability as a manually executed signature or the use of a paper-based recordkeeping system, as the case may be, to the extent
and as provided for in any applicable law, including the Federal Electronic Signatures in Global and National Commerce Act, the New York State Electronic Signatures and Records Act, or any other similar state laws based on the Uniform Electronic
Transactions Act. Without limitation to the foregoing, and anything in this Supplemental Indenture to the contrary notwithstanding, (a) any Officers’ Certificate, company order, Opinion of Counsel, Note, amendment, notice, direction,
certificate of authentication appearing on or attached to any Note, supplemental indenture or other certificate, opinion of counsel, instrument, agreement or other document delivered pursuant to the Indenture or this Supplemental Indenture may be
executed, attested and transmitted by any of the foregoing electronic means and formats and (b) all references to the execution, attestation or authentication of any Note or any certificate of authentication appearing on or attached to any Note
by means of a manual or facsimile signature shall be deemed to include signatures that are made or transmitted by any of the foregoing electronic means or formats. The Trustee shall have no duty to inquire into or investigate the authenticity or
authorization of any such electronic signature and shall be entitled to conclusively rely on any such electronic signature without any liability with respect thereto. 

  
 7 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written. 
  

					
	WMG ACQUISITION CORP.
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	 Executive Vice President,
 General Counsel and
Secretary

 [Signature Page to Fifth Supplemental Indenture] 

 
	
	Guarantors:
	
	A.P. SCHMIDT CO.
	ARTS MUSIC INC.
	ATLANTIC RECORDING CORPORATION
	ATLANTIC/MR VENTURES INC.
	AUDIO PROPERTIES/BURBANK, INC.
	BIG BEAT RECORDS INC.
	CAFÉ AMERICANA INC.
	CHAPPELL MUSIC COMPANY, INC.
	COTA MUSIC, INC.
	COTILLION MUSIC, INC.
	CRK MUSIC INC.
	E/A MUSIC, INC.
	ELEKSYLUM MUSIC, INC.
	ELEKTRA ENTERTAINMENT GROUP INC.
	ELEKTRA GROUP VENTURES INC.
	ELEKTRA MUSIC GROUP INC.
	ELEKTRA/CHAMELEON VENTURES INC.
	FHK, INC.
	FIDDLEBACK MUSIC PUBLISHING COMPANY, INC.
	FOSTER FREES MUSIC, INC.
	GENE AUTRY’S WESTERN MUSIC PUBLISHING CO.
	GOLDEN WEST MELODIES, INC.
	INSOUND ACQUISITION INC.
	INTERSONG U.S.A., INC.
	J. RUBY PRODUCTIONS, INC.
	JADAR MUSIC CORP.
	LEM AMERICA, INC.
	LONDON-SIRE RECORDS INC.
	MAVERICK PARTNER INC.
	MCGUFFIN MUSIC INC.
	MELODY RANCH MUSIC CO., INC.
	MIXED BAG MUSIC, INC.
	NONESUCH RECORDS INC.
	NON-STOP MUSIC HOLDINGS, INC.
	OCTA MUSIC, INC.
	PEPAMAR MUSIC CORP.
	REP SALES, INC.

 [Signature Page to Fifth Supplemental Indenture] 

 
	
	(cont-d):
	
	REVELATION MUSIC PUBLISHING CORPORATION
	RHINO ENTERTAINMENT COMPANY
	RICK’S MUSIC INC.
	RIDGEWAY MUSIC CO., INC.
	RIGHTSONG MUSIC INC.
	ROADRUNNER RECORDS, INC.
	RYKO CORPORATION
	RYKODISC, INC.
	RYKOMUSIC, INC.
	SEA CHIME MUSIC, INC.
	SIX-FIFTEEN MUSIC PRODUCTIONS, INC.
	SR/MDM VENTURE INC.
	SUMMY-BIRCHARD, INC.
	SUPER HYPE PUBLISHING, INC.
	THE ALL BLACKS U.S.A., INC.
	TOMMY VALANDO PUBLISHING GROUP, INC.
	UNICHAPPELL MUSIC INC.
	W.C.M. MUSIC CORP.
	WALDEN MUSIC INC.
	WARNER ALLIANCE MUSIC INC.
	WARNER BRETHREN INC.
	WARNER MUSIC PUBLISHING INTERNATIONAL INC.
	WARNER RECORDS INC.
	WARNER CUSTOM MUSIC CORP.
	WARNER DOMAIN MUSIC INC.
	WARNER MUSIC DISCOVERY INC.
	WARNER MUSIC LATINA INC.
	WARNER MUSIC SP INC.
	WARNER SOJOURNER MUSIC INC.
	WARNER SPECIAL PRODUCTS INC.
	WARNER STRATEGIC MARKETING INC.
	WARNER CHAPPELL MUSIC SERVICES, INC.
	WARNER CHAPPELL MUSIC, INC.
	WARNER CHAPPELL PRODUCTION MUSIC, INC.
	WARNER-ELEKTRA-ATLANTIC CORPORATION

 [Signature Page to Fifth Supplemental Indenture] 

 
	
	(cont-d):
	
	WARNERSONGS, INC.
	WARNER-TAMERLANE PUBLISHING CORP.
	WARPRISE MUSIC INC.
	WC GOLD MUSIC CORP.
	W CHAPPELL MUSIC CORP.
	WCM/HOUSE OF GOLD MUSIC, INC.
	WARNER RECORDS/QRI VENTURE, INC.
	WARNER RECORDS/RUFFNATION VENTURES, INC.
	WEA EUROPE INC.
	WEA INC.
	WEA INTERNATIONAL INC.
	WIDE MUSIC, INC.
	WMG RHINO HOLDINGS INC.
	ARTIST ARENA LLC
	ASYLUM LLC
	ASYLUM RECORDS LLC
	ASYLUM WORLDWIDE LLC
	ATLANTIC MOBILE LLC
	ATLANTIC PIX LLC
	ATLANTIC PRODUCTIONS LLC
	ATLANTIC RECORDING LLC
	ATLANTIC SCREAM LLC
	ATLANTIC/143 L.L.C.
	BB INVESTMENTS LLC
	BULLDOG ISLAND EVENTS LLC
	BUTE SOUND LLC
	CORDLESS RECORDINGS LLC
	EAST WEST RECORDS LLC
	ELEKTRA MUSIC LLC
	ELEKTRA RECORDS LLC
	FERRET MUSIC HOLDINGS LLC
	FERRET MUSIC LLC
	FERRET MUSIC MANAGEMENT LLC
	FERRET MUSIC TOURING LLC
	FOZ MAN MUSIC LLC
	FUELED BY RAMEN LLC
	LAVA RECORDS LLC
	MM INVESTMENT LLC
	P & C PUBLISHING LLC

 [Signature Page to Fifth Supplemental Indenture] 

 
	
	(cont-d):
	
	RHINO NAME & LIKENESS HOLDINGS, LLC
	RHINO ENTERTAINMENT LLC
	RHINO FOCUS HOLDINGS LLC
	RHINO/FSE HOLDINGS, LLC
	SODATONE USA LLC
	T-BOY MUSIC, L.L.C.
	T-GIRL MUSIC, L.L.C.
	THE BIZ LLC
	UPPED.COM LLC
	UPROXX LLC
	WARNER MUSIC DISTRIBUTION LLC
	WARNER MUSIC NASHVILLE LLC
	WARNER RECORDS/SIRE VENTURES LLC
	WARNER RECORDS LLC
	WMG COE, LLC
	WMG PRODUCTIONS LLC
	WRONG MAN DEVELOPMENT LIMITED LIABILITY COMPANY
	COMEDY TECHNOLOGIES, INC.
	DAQUAN MEDIA LLC
	SO SATISFYING LLC
	SOCIAL ACES, LLC
	ATLANTIC RECORDS GROUP LLC

  

					
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary of each of the above named entities listed under the heading Guarantors and signing this agreement in such capacity on behalf of each such entity

 [Signature Page to Fifth Supplemental Indenture] 

 
					
	WARNER MUSIC INC.
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	 Executive Vice President,
 General
Counsel & Secretary

	
	615 MUSIC LIBRARY, LLC
	
	By: Six-Fifteen Music Productions, Inc., its Sole Member
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary
	
	ARTIST ARENA INTERNATIONAL, LLC
	
	By: Artist Arena LLC, its Sole Member
	
	By: Warner Music Inc., its Sole Member
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	 Executive Vice President,
 General
Counsel & Secretary

 [Signature Page to Fifth Supplemental Indenture] 

 
					
	ALTERNATIVE DISTRIBUTION ALLIANCE
	
	By: Warner Music Distribution LLC, its Managing Partner
	
	By: Rep Sales, Inc., its Sole Member and Manager
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary
	
	MAVERICK RECORDING COMPANY
	
	By: SR/MDM Venture Inc., its Managing Partner
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary
	
	NON-STOP CATACLYSMIC MUSIC, LLC
	NON-STOP INTERNATIONAL PUBLISHING, LLC
	NON-STOP OUTRAGEOUS PUBLISHING, LLC
	
	By: Non-Stop Music Publishing, LLC, their Sole Member
	
	By: Non-Stop Music Holdings, Inc., its Sole Member
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary

 [Signature Page to Fifth Supplemental Indenture] 

 
					
	NON-STOP MUSIC LIBRARY, L.C.
	NON-STOP MUSIC PUBLISHING, LLC
	NON-STOP PRODUCTIONS, LLC
	
	By: Non-Stop Music Holdings, Inc., their Sole Member
		
	By:	 	 /s/ Paul M. Robinson

		 	Name:	 	Paul M. Robinson
		 	Title:	 	Vice President & Secretary

 [Signature Page to Fifth Supplemental Indenture] 

 
			
	WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee
		
	By:	 	 /s/ Linda Lopez

		 	Authorized Signatory

 [Signature Page to Fifth Supplemental Indenture]EX-10.1

 Exhibit 10.1 

FIFTH AMENDMENT TO LEASE 

THIS FIFTH AMENDMENT TO LEASE (this “Fifth Amendment”) is made as of August 11, 2021, by and between ARE-TECH SQUARE, LLC, a Delaware limited liability company (“Landlord”), and EPIZYME, INC., a Delaware corporation (“Tenant”). 

RECITALS 

A.    Landlord and Tenant are parties to that certain Lease Agreement dated as of June 15, 2012, as amended by
that certain First Amendment to Lease dated as of September 30, 2013, that certain Second Amendment to Lease dated as of May 18, 2016, that certain Third Amendment to Lease dated May 18, 2017 and that certain Fourth Amendment to Lease
dated May 18, 2017 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises commonly known as Suites 402, 501 and 601 containing approximately 43,066 rentable square feet (“Premises”),
in that certain building located at 400 Technology Square, Cambridge, Massachusetts. The Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the
Lease. 
 B.    Subject to the terms set forth in the Lease, the Base Term of the Lease is scheduled to expire on
November 30, 2022. 
 C.    Landlord and Tenant desire, subject to the terms and conditions set forth below
to amend the Lease to extend the Term of the Lease through November 30, 2024 (the “Extended Expiration Date”). 

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and
conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	 Term. The Term of the Lease is hereby extended through the Extended Expiration Date.
Tenant has accepted and occupies the Premises and Tenant’s continued occupancy of the Premises through the Extended Expiration Date shall be on an “as-is” basis, subject to the terms and
conditions of the Lease, and, except as expressly provided in Section 3 below, Landlord shall have no obligation to provide any tenant improvement allowance or make any improvements or alterations to the Premises.

  

	2.	 Base Rent. Tenant shall continue to pay Base Rent in accordance with the terms and
conditions of the Lease through November 30, 2022. In addition to all of its other obligations under the Lease, (i) commencing on December 1, 2022, Tenant shall pay Base Rent in the amount of $105.00 per rentable square foot of the
Premises per year (for clarity, in the aggregate amount of $4,521,930 per year) in equal monthly installments in accordance with the terms and conditions of the Lease, and (ii) commencing on December 1, 2023, Base Rent shall be increased
by 3% ($108.15 per rentable square foot per year, in the aggregate amount of $4,657,587.90 per year) through the Extended Expiration Date, payable in equal monthly installments in accordance with the terms and conditions of the Lease.

  

	3.	 Premises Improvements. Landlord shall make available to Tenant a tenant improvement
allowance in the amount of $10.00 per rentable square foot of the Premises, or $430,660.00 in the aggregate (the “Improvement Allowance”), for the design and construction of fixed and permanent improvements desired by and performed
by Tenant and reasonably acceptable to Landlord in the Premises (the “Premises Improvements”), which Premises Improvements shall 

  

	
	

	1

	 	
be constructed pursuant to a scope of work reasonably acceptable to Landlord and Tenant. Landlord’s failure to timely respond within 5 business days after a second written request to
Landlord regarding Tenant’s requested plans for the Premises Improvements shall be deemed an approval for purposes of this Fifth Amendment. The Improvement Allowance shall be available only for the design, construction, installation or
renovation of the Premises Improvements. Tenant acknowledges that upon the expiration of the Term of the Lease, the Premises Improvements shall become the property of Landlord and may not be removed by Tenant. Except for the Improvement Allowance,
Tenant shall be solely responsible for all costs of the Premises Improvements. The Premises Improvements shall be treated as Alterations and shall be undertaken pursuant to Section 12 of the Lease. The contractor for the
Premises Improvements shall be selected by Tenant, subject to Landlord’s approval, which approval shall not be unreasonably withheld, conditioned, or delayed. Prior to the commencement of the Premises Improvements, Tenant shall deliver to
Landlord a copy of any contract with Tenant’s contractors, and certificates of insurance from any contractor performing any part of the Premises Improvements evidencing the minimum coverage amounts specified in the Lease for commercial general
liability, automotive liability, “builder’s risk”, and workers’ compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and
Landlord’s lender (if any) as additional insureds for the general contractor’s liability coverages required above. 

During the course of design and construction of the Premises Improvements, Landlord shall reimburse Tenant for the cost of the Premises
Improvements once a month against a draw request in Landlord’s standard form, containing evidence of payment of the applicable costs and such certifications, lien waivers (including a conditional lien release for each progress payment and
unconditional lien releases for the prior month’s progress payments), inspection reports and other matters as Landlord customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days following receipt
of such draw request. Upon completion of the Premises Improvements (and prior to any final disbursement of the remaining Improvement Allowance) Tenant shall deliver to Landlord the following items: (i) sworn statements setting forth the names
of all contractors and subcontractors who did work on the Premises Improvements and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for the Premises Improvements. Notwithstanding the foregoing, if
the cost of the Premises Improvements exceeds the Improvement Allowance, Tenant shall be required to pay such excess in full prior to Landlord having any obligation to fund any remaining portion of the Improvement Allowance. The Improvement
Allowance shall only be available for use by Tenant in connection with the Premises Improvements to the extent requested by Tenant beginning on or after the date of execution of this Fifth Amendment through the date that is 12 months after the date
of execution of this Fifth Amendment (the “Outside Improvement Allowance Date”). Any portion of the Improvement Allowance which has not been properly requested by Tenant from Landlord on or before the Outside Improvement Allowance
Date shall be forfeited and shall not be available for use by Tenant. 
  

	4.	 Storage. The parties’ agreement regarding the storage space shall be governed by the
terms of that certain Storage Lease Agreement between the parties dated December 1, 2014. 

  

	5.	 Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any
broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected in this Fifth Amendment and that no Broker brought about this Fifth Amendment, other than CBRE and Newmark Knight Frank, which
parties will be compensated solely by Landlord pursuant to separate agreements. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from and against any claims by any Broker, other than CBRE and Newmark Knight Frank,
claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this Fifth Amendment. 

  

	
	

	2

	6.	 OFAC. Tenant and all beneficial owners of Tenant are currently (a) in compliance with
and shall at all times during the Term of the Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation
relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the Term of the Lease be listed on, the Specially Designated Nationals and Blocked Persons List maintained by OFAC and/or on any other
similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC
Rules. 

  

	7.	 Miscellaneous. 

a.    This Fifth Amendment, together with the Lease, is the entire agreement between the parties with respect to the
subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Fifth Amendment may be amended only by an agreement in writing, signed by authorized representatives of the parties hereto. 

b.    This Fifth Amendment is binding upon and shall inure to the benefit of the parties hereto and their respective
agents, employees, representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 

c.    This Fifth Amendment may be executed in 2 or more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic signature process complying with the U.S. federal ESIGN Act of 2000) or other
transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. Electronic signatures shall be deemed original signatures for purposes of this Fifth Amendment
and all matters related thereto, with such electronic signatures having the same legal effect as original signatures. 

d.    Except as amended and/or modified by this Fifth Amendment, the Lease (as amended) is hereby ratified and
confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Fifth Amendment. In the event of any conflict between the provisions of this Fifth Amendment and the provisions of the Lease, the
provisions of this Fifth Amendment shall prevail. Whether or not specifically amended or addressed by this Fifth Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and
intent of this Fifth Amendment. 
 [Signatures are on the next page] 

  

	
	

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 IN WITNESS WHEREOF, Landlord and Tenant have executed this Fifth Amendment as of the
day and year first above written. 
  

			
	TENANT:
	
	EPIZYME, INC.,
	a Delaware corporation
		
		 	/s/ John Weidenbruch
		
	By:	 	 John Weidenbruch

	Its:	 	General Counsel

  

									
	LANDLORD:
	
	ARE-TECH SQUARE, LLC,
	a Delaware limited liability company
		
	By:	  	 ARE-MA REGION NO. 31, LLC,

a Delaware limited liability company,
 its manager

			
		  	By:	  	ALEXANDRIA REAL ESTATE EQUITIES, L.P., a Delaware limited partnership, managing member
				
		  		  	By:	  	 ARE-QRS CORP.,

a Maryland corporation,
 general partner

					
		  		  		  		  	/s/ Kristen Childs
					
		  		  		  	 By:
	  	 Kristen Childs

		  		  		  	Its:	  	Senior Vice President, 
		  		  		  		  	RE Legal Affairs

  

	
	

	4

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