Document:

Master Services Agreement

 Exhibit 10.4 
  
 ICON 
 MASTER SERVICES AGREEMENT 
  

			
	AGREEMENT:	  	made as of December 1, 2003 (“Effective Date”)
		
	BETWEEN:	  	ICON Clinical Research, L.P.,
	 	  	a Delaware Partnership, located at
	 	  	212 Church Road, North Wales, PA 19454
	 	  	(hereinafter called “ICON”)
		
	AND:	  	Neurobiological Technologies, Inc. located at
	 	  	3260 Blume Drive, Suite 500
	 	  	Richmond, CA 94806
	 	  	(hereinafter called “NTI”)

  
 RECITALS

  
 A. WHEREAS, ICON is a Delaware partnership and is a
Contract Research Organization engaged in the business of providing personnel and expertise to the Pharmaceutical and Biotechnology Industries worldwide in the areas of management of clinical trials, data management, statistical analysis and
reporting of clinical studies; and 
  
 B. WHEREAS, NTI is a
Delaware Corporation and is engaged in the development of pharmaceutical products; and 
  
 C. WHEREAS, NTI may wish to retain the services of ICON from time to time to perform clinical research and related services (the “Services”) in connection with certain clinical research projects
(individually, a “Project” and collectively “Projects”), as are specified in separate Project Contracts in accordance with the terms of this Master Agreement (“Project Contracts”) and the protocols
identified in the Project Contracts, to the extent that the obligations set forth in such protocols are transferred to ICON as set forth in the Project Contracts; and 
  
 D. WHEREAS, the parties hereto desire to agree upon various terms and conditions that will govern their business
relationship for the term specified herein in connection with the Projects. 
  
 NOW THEREFORE, THE PARTIES HERETO AGREE AS FOLLOWS: 
  

	1.	SERVICES & OBLIGATIONS OF THE PARTIES: 

  
 1.1 Purpose: The purpose of this document is to establish a Master Services Agreement between ICON and NTI for the provision of Services relating
to the management and conduct of clinical drug studies carried out by or on behalf of NTI, together with the provision of related Services as appropriate. 
  

 1.2 Competitive Bid: Whenever NTI wishes ICON to work on a Project under this Master Agreement,
NTI will invite ICON by means of a Request for Proposal (“RFP”), to bid competitively on the Project. NTI and ICON will subsequently meet to discuss the specifications, responsibilities, costs and other pertinent aspects of the
Project outlined in the RFP, and ICON will provide a competitive offer document, which shall include a cost proposal and assumptions applicable to that Project showing all direct ICON costs, as well as pass-through costs. 
  
 1.3 Contract Execution: In the event that the parties shall reach
agreement with respect to a particular Project, the parties shall execute a Project Contract substantially in the form of Attachment A hereto, Sample Project Contract, with respect to such Project. ICON shall not enter into any Project Contract with
respect to which it does not reasonably believe that the Services covered thereby will be accomplished within the budgeted costs therein. To the extent applicable, each Project Contract shall contain a detailed and specific transfer of obligations
to ICON as required by 21 C.F.R. 312.52. 
  
 1.4 Collective
Agreement: Upon execution of a Project Contract, that Project Contract shall be attached to this Master Agreement and shall collectively, independent from any other Project Contracts, constitute the entire agreement for the specific Project.
This Master Agreement shall be deemed to apply to each such Project Contract so executed as fully and with like effect as though this Master Agreement was re-executed at the time such Project Contract is executed. No Project Contract shall be
attached to this Master Agreement without first being executed by the parties hereto. 
  
 1.5 Master Agreement to Prevail: To the extent there is any conflict between the terms of this Master Agreement and a separate Project Contract, the terms of this Master Agreement shall govern unless such
Project Contract specifically identifies any modification to the Master Agreement. Any such modification shall apply only to the Project(s) pertaining to such Project Contract and shall not act as an amendment of this Master Agreement as it relates
to any prior or subsequent Project Contract. 
  
 1.6 Provision
of Services: ICON hereby agrees that it will use its best commercial efforts to perform all Services in accordance with any applicable deadlines set forth herein or any Project Contract, or as may be subsequently agreed between the parties. ICON
shall perform all Services diligently, in good faith and to the best of its ability. In performing the Services, ICON shall comply with the applicable Protocol (said “Protocol” to be attached as an Exhibit to the Project Contract),
as may be amended by NTI from time to time with advance written notice thereof to ICON, and all applicable (i) published guidelines and other generally accepted standards of good clinical practice and good medical practice; (ii) federal, state and
local laws, rules, regulations, guidance’s and guidelines, including ICH guidelines, relating to the conduct of clinical investigations, including, but not limited to, the Federal Food, Drug and Cosmetic Act, as amended; and (iii) other laws,
rules, regulations and guidelines pertaining to clinical investigations and the use of study drugs in humans, including, without limitation, 21 C.F.R. Parts 50, 54, 56 and 312 (the “Applicable Laws, Regulations, Guidelines and Standards”).
In the event of a conflict between any Applicable Laws, Regulations, Guidelines and Standards, ICON shall comply with the most appropriate law, regulation, guideline and/or standard. 
  

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 1.7 Antecedent Services: Within sixty (60) days of a written award of a Project to ICON from NTI,
ICON shall require the execution of a signed, written agreement, in the form of either a formalized Project Contract or Letter of Intent. In the event that ICON, in good faith and at the written request of NTI, provides Services to NTI prior to, or
in contemplation of, the formal execution of a Project Contract in respect of any Project intended by the parties to be governed by the terms of this Master Agreement, ICON shall be entitled to payment by NTI in respect of any Services so provided
notwithstanding that such Project Contract shall not have been formally executed by the parties. In the absence of agreement to the contrary, ICON shall invoice NTI monthly in respect of any such antecedent services and such invoices shall be due
and payable within thirty (30) days of receipt by NTI. Additionally, ICON will not guarantee the continued availability of the staff assigned to the Project beyond sixty (60) days of its award without the execution of a signed, written agreement as
contemplated above. 
  
 1.8 Drug and Device Supplies: In
the event that a particular Project Contract requires the delivery to ICON of any drugs or medical devices, NTI shall use reasonable efforts to supply sufficient clinical supplies of any Project drug and/or device necessary to conduct the Project.

  

	 	(a)	The Project drug and/or device will be shipped properly packaged and labeled by NTI or representative of NTI to ICON for distribution or directly to the investigators or
investigational sites or institutions (collectively “Investigators”). NTI represents and warrants that all necessary approvals under the United States Food, Drug and Cosmetic Act, the regulations promulgated thereunder and other
state and federal regulatory approvals shall be obtained prior to the shipment of any drugs or devices. 

  

	 	(b)	All Project drug supplied to ICON and to Investigators shall remain the exclusive property of NTI or its affiliates until administered or dispensed to patients during the course of
the Project. In no event shall any Project drug supplied to ICON for use in the Project be used by ICON for any purpose other than as contemplated by the Protocol, or be delivered to any person other than an Investigator participating in the
Project. For purposes of the Project, ICON shall use only such labeling for the Project drug as is contained in the Investigator’s brochure (including any amendments thereto) or otherwise provided by NTI. 

  

	 	(c)	At the completion of the Project, ICON will provide to NTI a written accounting of all clinical supplies used in the Project. ICON will use its best efforts to return all unused
Project drug or devices unless otherwise instructed. During the Project, ICON will ensure that the Investigators maintain records of (i) the dates and amounts of Project drug and devices received at the Project site, (ii) the dates, amounts and
subjects to whom the Project drug and device has been dispensed, (iii) the dates and amount of Project drug broken, spilled or lost, and (iv) the dates and amounts of Project drug and devices being returned. 

  

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 1.9 Records: All records, data, files, documents, samples, devices, products, equipment and other
materials, including copies, electronic media and computerized records (whether magnetic, optical or otherwise), that ICON controls, possesses or creates as a result of providing the Services, whether or not confidential (collectively,
“Records”), are the sole and exclusive property of NTI. ICON shall maintain all Records in a safe and secure manner and in compliance with all Applicable Laws, Regulations, Guidelines and Standards. Except as otherwise expressly
provided by any Applicable Laws, Regulations, Guidelines and Standards, ICON shall store all Records in compliance with the appropriate record retention regulations. Thereafter, prior to disposal of any Records, ICON shall give NTI not less than 60
days written notice, and, if NTI so requests prior to such disposal, ICON shall transfer such Records to NTI. ICON shall make any and all Records available for inspection or duplication by NTI’s authorized representatives during normal business
hours. At any time, NTI may request that ICON (i) deliver any or all Records to NTI or to a location specified by NTI, or (ii) dispose of Records as directed by NTI, unless such Records are required by applicable law or regulation to be stored or
maintained. 
  
 1.10 Regulatory Inspections: ICON shall
cooperate with NTI in accommodating any visits, investigations or inspections by regulatory authorities or other governmental authority, whether announced or unannounced. Upon notification of an impending inspection by any regulatory agency or other
governmental authority at ICON’s premises, or at any monitored site, ICON shall notify NTI immediately. 
  

	2.	RELATIONSHIP BETWEEN THE PARTIES: 

  
 2.1 Independent Contractor: In undertaking to perform Services hereunder, ICON is doing so as an independent contractor, and nothing in this Master
Agreement or any Project Contract shall be construed as creating any relationship of partnership, joint venture or agency as and between the parties hereto. No relationship of employer or employee shall arise or be created under this Master
Agreement or any Project Contract as and between NTI and ICON and/or any personnel engaged by ICON to perform the Services (“ICON Personnel”). ICON Personnel shall not be eligible for any NTI employee benefits, nor shall NTI be
obliged to make any deductions from ICON’S fees for taxes, such taxes being the sole responsibility of ICON. Neither party shall have any authority by virtue of this Master Agreement to contract or otherwise act on behalf of the other. Neither
party shall represent itself as an agent of the other. 
  
 2.2
Staffing Warranties: ICON shall be responsible for providing all ICON Personnel involved in the Project undertaken by it hereunder, as well as any necessary replacements. ICON represents, warrants and covenants that it shall provide
appropriately trained ICON Personnel, qualified by education and experience to manage and monitor the Project; that ICON Personnel have, and at all times during the term of this Master Agreement shall have, appropriate licenses, approvals and
certifications necessary to safely, adequately and lawfully perform the Services; and that neither ICON nor ICON Personnel is subject to any conflicting obligations or legal impediments that might interfere with the performance of the Project or
that might impair the acceptance of the resulting data by the FDA, and no such obligations or impediments will be incurred or permitted during the term of this Master Agreement without the prior written approval of NTI. 
  

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 2.3 Personnel Assigned: The initial Project team assigned to an applicable Project shall be
acceptable to and approved by NTI in advance of the start of the Project. The Services with respect to each Project shall be performed by ICON under the direction of the person identified as the Project Manager in the applicable Project Contract or
such other person acceptable to NTI as ICON may from time to time designate as the Project Manager. ICON shall be obligated at all times to use its best commercial efforts to provide a sufficient number of competent personnel on a given Project to
meet the demands of the Project. 
  
 2.4 Change of
Personnel: ICON agrees to use its best efforts to ensure the continuity of competent ICON Personnel assigned to provide services under this Master Agreement. Subject to Section 2.6, ICON reserves the right to change any assigned ICON Personnel
provided that: 
  

	 	(a)	at least two (2) weeks prior notice in writing of such proposed change is given to NTI; and 

  

	 	(b)	ICON Personnel proposed for replacement shall have substantially equivalent qualifications as the personnel being replaced; and 

  

	 	(c)	NTI shall have the right to meet and interview any replacement ICON Personnel prior to their appointment to a study provided that NTI hold the meeting/interview promptly.

  
 NTI shall have the right to require that any
ICON Personnel be removed from providing any Services with reasonable cause. 
  
 2.5 Corporate Affiliates of ICON Permissible: NTI agrees that ICON may use the services of corporate affiliates to fulfill ICON’S obligations under such Project Contract. Any affiliates so used shall sign
the Project Contract pursuant to which it is providing Services and be subject to all of the terms and conditions applicable to ICON under this Master Agreement; provided that ICON shall also be responsible for the acts and omissions of such
Corporate Affiliates as if the Services were performed by ICON. For the purposes of this provision a “Corporate Affiliate” of a party shall mean a company, which directly or indirectly, controls, is controlled by or is under common
control with one of the parties. Control means ownership of at least fifty percent (50%) of the capital stocks or the voting rights of the respective company. 
  

2.6 Key Personnel: So long as any persons designated as key ICON Personnel in a Project Contract (collectively, “Key
Personnel”) are employed by ICON, they shall be assigned to provide Services to NTI, and ICON shall make every effort that Key Personnel not be replaced nor have their responsibilities materially reduced or altered other than at the request
of NTI. In the event any Key Personnel should leave the employ of ICON, or change positions or responsibilities within ICON, their replacements shall be assigned to the Services only upon the written approval of NTI. 
  
 2.7 Staff Solicitation: During the term of each Project, and for one
year thereafter, NTI agrees not to solicit, directly or indirectly, any employee of ICON performing Services on such Project for employment with NTI, whether as an employee, independent contractor, or otherwise. 
  

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 2.8 Investigator Contract Format: If a particular Project Contract obliges ICON to contract with
Investigators or facilitate NTI’s contracting with Investigators (or other independent contractors such as central laboratories), then any such contract shall be in a form mutually acceptable to NTI and ICON, which contract shall include,
without limitation, provisions addressing the specific duties and standards of the parties, confidentiality, indemnification, ownership of intellectual property and debarment certification. 
  

	3.	TERM & TERMINATION: 

  
 3.1 Term of Master Agreement: This Master Agreement shall commence on the Effective Date hereof and shall continue for a period of five (5) years,
unless terminated prior to expiration as set forth herein. Notwithstanding the expiration of this Master Agreement, the terms and conditions of this Master Agreement and each applicable Project Contract shall continue to apply, and the parties shall
continue to perform in accordance with this Master Agreement and the applicable Project Contract with respect to each Project to which the parties shall have signed a Project Contract prior to the effective date of expiration of this Master
Agreement. 
  
 3.2 Agreement Renewable: This Master
Agreement shall be renewable upon terms and conditions mutually acceptable to the parties hereto. 
  
 3.3 Early Termination: This Master Agreement and/or any Project Contract promulgated hereunder is subject to earlier termination: 
  

	 	(a)	by mutual written consent of both parties hereto; 

  

	 	(b)	by either party if a party commits any breach of any of the provisions of this Master Agreement and/or any Project Contract, and, in the case of a breach capable of remedy, fails to
remedy the same within thirty (30) days after receipt of a written notice from the other party giving full particulars of the breach and confirming the intention to terminate if not remedied; 

  

	 	(c)	immediately, if either party shall become bankrupt or insolvent or if all or a substantial part of its business or assets shall be placed in the hands of a Receiver, Administrator,
Administrative Receiver, Trustee in Bankruptcy or similar or analogous officer or an insolvency practitioner, whether by its voluntary act or otherwise; 

  

	 	(d)	as to any Project Contract entered into pursuant to this Master Agreement, upon forty five (45) days prior written notice by NTI to ICON; provided however, that the Project may be
terminated by NTI for reasons of patient safety and in such an event the 45 day notice requirement shall not apply to the Project termination and Project termination shall be effective immediately upon written notification or notification by
telephone, which shall then be followed by written confirmation. 

  
 3.4 Survival of Rights on Termination: The expiration or earlier termination of this Master Agreement for whatever reason shall not affect the accrued rights of either NTI or ICON 

  

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arising under or out of this Master Agreement, and all provisions which are expressed to or by implication survive this Master Agreement shall remain in full
force and effect, including but not limited to Sections 1.5, 1.8,1.9, 2.1, 2.7, 3.4, 3.5, 3.6, 5, 6, 8 and 9. 
  
 3.5 Return of Materials on Termination: Upon termination of this Master Agreement for any reason, subject to ICON’s Record retention
obligations under Section 1.9 of this Master Agreement, ICON shall promptly deliver to NTI all documents, data and materials in whatever form (including any reproductions of same) of any nature pertaining to ICON’s provision of Services under
this Master Agreement and/or pertaining to any Confidential Information as described in Section 5. Notwithstanding the foregoing, ICON may retain, solely for the purpose of determining the scope of its obligations under this Master Agreement, one
(1) copy of documents, data or other materials generated hereunder. 
  
 3.6 Transition Upon Termination: Upon termination of any Project Contract or this Master Agreement, ICON agrees to (i) cooperate with NTI to provide for an orderly wind-down of the terminated Services provided by ICON, (ii) reduce or
eliminate further costs, and (iii) cancel, if permitted under the terms of any applicable agreements, any third party obligations or, at NTI’s request, promptly assign to NTI (or its designee) any subcontracts or other arrangements which ICON
may have entered into in connection with ICON’s provision of Services and to cooperate with NTI in good faith to facilitate the transition of such subcontracts or arrangements and the Services to be performed thereunder to NTI. NTI’s
obligation with respect to outstanding expenses and commitments shall be contingent upon receipt of proof satisfactory to NTI that such expenses have been paid and cannot be cancelled or recovered. Any funds held by ICON which are unearned at the
date of termination shall be returned to NTI within forty-five (45) days of the date of termination of the Master Agreement or Project Contract, as applicable. 
  

	4.	PAYMENT: 

  
 4.1 Budget/Schedule of Fees: A budget and schedule of fees and payments for the provision of the Services, as agreed between the parties, shall be
included in each Project Contract and shall be attached to this Master Agreement. NTI shall pay ICON in respect of Services provided in accordance with the terms and conditions set out in each applicable Project Contract and in accordance with the
terms and conditions of this Master Agreement. 
  
 4.2 Payment
Terms: Any invoices submitted by ICON to NTI shall, at NTI’s request,- include documentation and/or detail acceptable to NTI and are due and payable within thirty (30) days of receipt. Invoices may reference milestones and/or deliverables
completed, including dates completed, as specified in the Project Contract. All pass-through costs shall be itemized in a form and in such detail as is agreed between the parties. Taxes (and any penalties thereon) imposed on any payment made by NTI
to ICON shall be the responsibility of ICON. Invoices will be submitted to NTI’s representative as specified in the Project Contract. 
  

	 	(a)	 Unless otherwise expressly provided in the applicable Project Contract, ICON shall submit to NTI an invoice describing in reasonable detail the Services provided
and costs incurred during a particular month on a monthly basis and NTI shall pay all invoiced amounts within thirty (30) 

  

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days of receipt of such invoice. Interest may be charged in the amount of 1% per month (or part thereof) in respect of all invoices paid later than thirty
(30) days after issue; provided, however, that interest shall not be charged on portions of payments withheld pending the resolution of a good faith dispute. 

  

	 	(b)	If any portion of an invoice is disputed, the parties shall use good faith efforts to reconcile differences or discrepancies with regard to any disputed amount as soon as
practicable. 

  
 4.3 Change Notices/Orders:
Any material change initiated by NTI in the details of a Project Contract promulgated under this Master Agreement or the assumptions upon which such Project Contract is based (including, but not limited to, changes in an agreed starting date for a
Project or suspension of such Project by NTI) or a delay in the provision of Project materials or information by NTI may require changes in the budget and/or timelines, and shall require a written amendment to the Project Contract (a “Change
Order”). Each Change Order shall detail the requested changes to the applicable task, responsibility, duty, budget, timeline or other matter. The Change Order will become effective as an amendment to the relevant Project Contract and this
Master Agreement upon the execution of the Change Order by both parties’ authorized representatives, and ICON will be given a reasonable period of time within which to implement the changes. ICON shall be under no obligation to provide
additional resources or Services, and NTI shall be under no obligation to pay for additional resources or Services, in the absence of agreement between the parties in respect of the costs of such additional resources or Services. Both parties agree
to act promptly and in good faith when considering a Change Order requested by the other party. 
  
 4.4 Reimbursement for Expenses: NTI agrees to pay ICON, for all reasonable and necessary out-of-pocket expenses incurred by ICON in performing the
Services; provided, however, that (a) all travel shall be subject to NTI’s travel policies as provided to ICON in advance of such travel, (b) any individual expense greater than $250 shall require NTI’s prior written approval and (c) each
Project Contract shall specify the maximum aggregate out-of-pocket expenses for such Project. NTI shall pay such expenses within thirty (30) days after ICON has provided to NTI, in form and content reasonably satisfactory to NTI, original receipts
and other appropriate documentation evidencing such expenses. The parties may agree in each Project Contract for the advance payment of estimated expenses so that ICON may remain cash neutral in respect of such expenses and payments. 
  
 4.5 Payment for Premature Termination: In the event that a Project
Contract is terminated prior to conclusion of the Project pursuant to Section 3.3(d), then in lieu of amounts otherwise payable under Section 4, NTI shall pay ICON the following amounts within thirty (30) days of receipt by NTI of ICON’s
itemized statement if the amount already paid by NTI to ICON in connection with the Project is less than the amount to which ICON is entitled hereunder: 
  

	 	(a)	 payment for all Services performed but not paid through the date of termination under the terminated Project in accordance with the budget and schedule set forth in
the Project Contract; provided however, that if the payment schedule for Services in the Project Contract is 

  

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milestone-based; payment shall be made on a pro rata basis based on the amount of Services provided by ICON through the effective date of termination
pursuant to the terms of the Project Contract; and 

  

	 	(b)	All non-cancelable pass-through payments payable to third parties pursuant to Section 4.4 and not yet paid by NTI. 

  
 If the amounts paid by NTI to ICON in connection with the Project exceeds the
amount to which ICON is entitled, then ICON shall promptly refund such excess to NTI. 
  
 4.6 Address for Payments: All payments required to be made to ICON by NTI shall be in the form of a check drawn on a U.S. bank, payable to ICON Clinical Research L. P. Checks shall be mailed to: 
  
 ICON Clinical Research, L.P. 
 P.O. Box 82-8268 
 Philadelphia, PA 19182-8268

 Attn: David Peters, Vice President of Finance 
 Tax Payer I.D. Number: 52-2133696 
  

	5.	CONFIDENTIALITY• INTELLECTUAL PROPERTY: 

  
 5.1 Confidential Information: In furtherance of the conduct of the Project Contracts conducted under this Master Agreement, it may be necessary or
desirable for the parties hereto to disclose proprietary, trade secret and/or other Confidential Information to one another or to Investigators participating in the Projects conducted under this Master Agreement. All such Confidential Information
shall remain the property of the party disclosing it. Each party hereto agrees that any such Confidential Information disclosed to it or learned, generated or derived by it or its employees, agents and contractors during the course of carrying out
the Services, shall only be used in connection with the legitimate purposes of this Master Agreement. Confidential Information of a party shall not be disclosed, publicized, disseminated, promoted, advertised or permitted to be disclosed by the
other party, except for disclosures to those employees, agents and contractors who have a need to know it in connection with the party’s obligations under this Master Agreement and who are obligated to keep same in confidence by written
agreement with the party on terms no less stringent than those set forth in this Section 5. Each party shall safeguard Confidential Information of the other party with all reasonable care. 
  
 5.2 Definition of Confidential Information: For the purposes of this
Master Agreement, “Confidential Information” shall mean any and all information in whatever form pertaining to all Inventions as defined hereinafter, trade secrets, ideas, processes, programs and all tangible and intangible information
relating to formulations, products, processes, know-how, designs, formulas, methods, developmental or experimental work, clinical data, improvements, discoveries, pending or potential patent claims and any information derived therefrom, plans for
research, new products, marketing and selling plans, business plans, budgets and unpublished financial statements, licenses, pricing and costing information, identities of suppliers, customers or clients and information regarding the skills and
compensation of employees or other consultants of NTI or ICON. 
  

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 5.3 Term of Confidentiality: Each party’s obligations of nondisclosure and nonuse under this
Section 5 shall apply at all times during the term of this Master Agreement and for a period of five (5) years thereafter. 
  
 5.4 ICON to Bind Other Parties: ICON shall be responsible for binding to the terms and conditions of this Master Agreement and, in accordance
herewith, shall be responsible for ensuring that any servants or agents, or any other persons who receive Confidential Information through it, are bound under the terms of this Master Agreement. 
  
 5.5 Exclusions: The confidentiality obligations of the parties in
Sections 5.1 to 5.4 shall not extend to any Confidential Information which: 
  

	 	(a)	is or becomes generally available to the public otherwise than by reason of a breach by the recipient of Sections 5.1 to 5.4 above; or 

  

	 	(b)	is known to the recipient party and is at its free disposal prior to its receipt from the other, as evidenced by written records or oral evidence; or 

  

	 	(c)	is subsequently disclosed to the recipient party by a third party who is not under any obligation of confidentiality with respect to such information; or 

 

	 	(d)	is disclosed by ICON to a third party to such extent only as is necessary for the purposes contemplated by this Master Agreement and subject to ICON using all reasonable endeavors
to ensure that the person in question keeps the same confidential and does not use the same except for the purposes for which the disclosure is made. 

  
 5.6 Disclosure by Law: Confidential Information may also be disclosed to the extent required by applicable law
provided that the party making such disclosure of the other party’s Confidential Information shall give maximum practical advance notice of same to the other party hereunder and shall request maximum protective or confidential treatment of such
disclosure from the recipient thereof as may be afforded by law. At the other party’s request and sole cost, the party obligated to disclose Confidential Information shall cooperate with and assist the other party in obtaining a protective
order or confidential treatment with respect to any Confidential Information required to be disclosed. 
  
 5.7 Inventions: Any inventions or discoveries (whether or not patentable), innovations, suggestions, ideas and reports (“Inventions”),
conceived, reduced to practice, made or developed by ICON as a result of performing the Services shall be promptly disclosed to NTI and shall be the sole and exclusive property of NTI. 
  
 5.8 Ownership of Data and Technology: All aspects of data processing and management systems prepared or developed by
ICON specifically for NTI’s use only pursuant to this Master Agreement and/or any of its addenda (including but not limited to hardware, software, written materials manifested in programs, documentation, design, discoveries or improvements)
shall be the sole and exclusive property of NTI and shall be considered Confidential Information of NTI. 
  

	 	(a)	The disks and/or tapes upon which the clinical data generated from the performance of the Projects conducted under this Master Agreement are entered and stored are the sole and
exclusive property of NTI. 

  

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	 	(b)	All data, documents, information, reports and other materials provided by NTI to ICON and all data, documents, information, reports or other materials generated by clinical
investigators for ICON and all data, documents, information, reports or other materials prepared by ICON in connection with the Projects conducted under this Master Agreement, shall be the sole and exclusive property of NTI.

  
 5.9 Cooperation by ICON to Prosecute
Protection: Upon NTI’s request and at NTI’s expense, ICON shall execute such documents and take such actions, as NTI deems necessary or appropriate to obtain patent or other proprietary protection in NTI’s name concerning any
Inventions. The obligations of Sections 5.1 to 5.8 inclusive shall apply to ICON’s employees, agents and representatives involved in the provision of the Services under this Master Agreement and ICON agrees to cause such parties to execute
agreements ensuring compliance with these Sections. 
  

	6.	LIABILITY & INDEMNITY: 

  
 6.1 Indemnification by ICON: ICON hereby agrees to indemnify NTI and its officers, directors, employees and agents from any loss, damage, cost or
expense (including reasonable attorney’s fees) (“Loss”) arising from any third party claim, demand, assessment, action, suit or proceeding (“Claim”) arising out of or occurring as a result of ICON’s
negligence, gross negligence, intentional misconduct or inaction in the performance of the Services, or otherwise relating to this Agreement or the parties, or breach of this Master Agreement or any Project Contract; provided that if such Loss or
Claim arises in whole or in part from NTI’s negligence, gross negligence, intentional misconduct or inaction, or breach of this Master Agreement or any Project Contract, then the amount of the Loss that ICON shall indemnify NTI for shall be
reduced by an amount in proportion to the percentage of NTI’s responsibilities for such Loss as determined by a court of competent jurisdiction in a final and non-appealable decision or in a binding settlement between the parties. 

 
 6.2 Indemnification by NTI: NTI hereby agrees to indemnify ICON and
its officers, directors, employees, agents and Approved Sub-Contractors from Loss arising from any Claim arising out of or occurring as a result of NTI’s negligence, gross negligence, intentional misconduct or inaction, or breach of this Master
Agreement or any Project Contract; provided that if such Loss or Claim arises in whole or in part from ICON’S negligence, gross negligence, intentional misconduct or inaction, or breach of this Master Agreement or any Project Contract, then the
amount of the Loss that NTI shall indemnify ICON for shall be reduced by an amount in proportion to the percentage of ICON’s responsibilities for such Loss as determined by a court of competent jurisdiction in a final and non-appealable
decision or in a binding settlement between the parries. 
  

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 6.3 Obligations of the Parties: Each party seeking indemnity under this Section must: 

 

	 	(a)	authorize and permit the indemnifying party to conduct and exercise sole control of the defense and disposition (including all decisions relative to litigation or appeal) of such
Claims (including access to pertinent records and documents and provision of relevant testimony); provided that the indemnifying party may not settle any Claims without the indemnitee’s prior written consent, which consent shall not be
unreasonably withheld or delayed. 

  

	 	(b)	subject to the foregoing, be permitted to participate in the defense of any such Claims at its own cost and expense. 

  
 6.4 Notice of Claim: A party seeking indemnification under this
Section 6 shall give the indemnifying party written notice of any Claim (including a copy of any such Claim served upon indemnitee), within ten (10) business days after such Claim was served upon the indemnitee; provided, however, that the failure
of a party to provide notice within the specified time period will not relieve the indemnifying party from its obligations hereunder except to the extent it has been prejudiced by the failure to give timely notice. The indemnifying party shall
defend the indemnitee from any Claim at its sole cost and expense and shall keep the indemnitee informed as to the progress of its defense and disposition (including without limitation, settlement, litigation or appeal) of any such Claims.

  
 6.5 Exclusion of Consequential Loss: Subject to the
provisions of Sections 6.1, 6.2 and 6.6, neither party shall be liable to the other for loss, damage, or liability in respect of loss of profits, business or revenue loss, special, indirect or consequential loss (even if foreseeable or in the
contemplation of either party). 
  
 6.6 Personal Injury:
Nothing herein shall purport to exclude or restrict liability of either party for death or personal injury howsoever occasioned. 
  
 6.7 Maintenance of Insurance: ICON and NTI shall at their own expense obtain and maintain insurance of a type and amount adequate to cover all
loss, damage, liability or costs in respect of which it is liable to indemnify the other under the provisions of this Section, to the extent commercially reasonable and shall not do or omit any act, matter or thing which may prejudice or render
voidable any such insurance. Each party will, forthwith on request by the other, provide the party requesting the same with evidence of the insurance as that party may reasonably require. 
  
 The insurance coverage required hereunder shall be continuously maintained during the performance of this Master Agreement
and, if on a “claims made” basis, for five years thereafter. Each party shall notify the other party at least 30 days prior to any cancellation, intent of insurer not to renew or any material change in the insurance contract or coverages
afforded. Each party shall be solely responsible for the payment of any deductible or self-insured retention under each of their respective policies. 
  

	7.	REGULATORY MATTERS: 

  
 7.1 Generic Drug Enforcement Act of 1992 Compliance: ICON hereby certifies to NTI that ICON is not and has not been debarred under the U.S. Generic
Drug Enforcement Act 

  

 12 

 
of 1992, 21 U.S.C. Sections 335(a) and (b), as amended (GDEA). ICON further represents and warrants that it has not used and will not knowingly use the
services, in any capacity or in connection with any of the Services performed pursuant to this Master Agreement of any individual, corporation, partnership or association which has been debarred. If at any time ICON becomes aware that it or any
individual, corporation, partnership or association providing services to it in connection with the Services has been or is in the process of being debarred, ICON shall immediately notify NTI in writing and if such debarment prejudices the
performance of any Project, NTI shall have the right to terminate this Master Agreement upon notice without penalty to NTI therefore. Upon request by NTI, ICON agrees to provide a list of persons used to perform the Services provided pursuant to
this Master Agreement who to ICON’s knowledge, within the five (5) years preceding the Effective Date, or subsequent to the Effective Date, were or are convicted of one of the criminal offenses required by the GDEA to be listed in any
application for approval or an abbreviated application for drug approval. 
  
 7.2 Securities Laws: The parties hereby acknowledge that ICON is publicly traded on the NASDAQ National Market System under the respective symbol “ICLR”. The parties are aware that the United States
and individual states’ securities laws prohibit any person who has material, nonpublic information concerning a company from purchasing or selling securities of that company or from communicating such information to any other person under
circumstances in which it is reasonably foreseeable that such person is likely to purchase or sell such securities. 
  

	8.	GENERAL PROVISIONS: 

  
 8.1 Assignment: This Master Agreement and subsequent Project Contracts may not be assigned by ICON without the prior written consent of to NTI.

  
 8.2 Subcontracting: ICON shall be entitled to use
agents and subcontractors in the provision of Services under this Master Agreement, provided that (i) all such agents and subcontractors shall be subject to the prior written approval of NTI, (ii) any agent or subcontractor shall be subject to the
same obligations as ICON hereunder and (iii) ICON will be responsible for the acts and omissions of such agents and subcontractors as if the Services were performed by ICON (“Approved Sub-Contractors”). No Approved Sub-Contractor
may further subcontract any rights or obligations hereunder or under any Project Contract without first obtaining NTI’s prior written approval. 
  
 8.3 Notices: Any notice or other communication to be given under this Master Agreement shall be in writing and shall be delivered personally or
sent by first- class pre-paid U.S. Mail, overnight delivery service or facsimile transmission (confirmed by first-class pre-paid U.S. Mail) addressed as follows: 
  

			
	If to NTI to:	  	Neurobiological Technologies, Inc.
	 	  	Attn: Heather McLaughlin
	 	  	Clinical Project Manager
	 	  	3260 Blume Drive, Suite 500
	 	  	Richmond, CA 94806
	 	  	Phone: 510-262-1730
	 	  	Fax: 510-262-0204
	 	  	Email: heatherm@ntii.com

  

 13 

			
	With copy to:	  	Neurobiological Technologies, Inc.
	 	  	Attn: Maureen Wesley
	 	  	Manager, Administration
	 	  	3260 Blume Drive, Suite 500
	 	  	Richmond, CA 94806
	 	  	Phone: 510-262-1730
	 	  	Fax: 510-262-0204
	 	  	Email: wesleym@ntii.com
		
	If to ICON to:	  	ICON Clinical Research, L.P.
	 	  	Attn: Katie Ruane
	 	  	Contract Associate - Business Development
	 	  	212 Church Road
	 	  	North Wales, PA 19454
	 	  	Phone: 215-616-3641
	 	  	Fax: 215-616-3095
	 	  	Email: ruanek@iconus.com
		
	With copy to:	  	ICON Clinical Research Limited
	 	  	Attn: Aislinn Fleming
	 	  	Legal Affairs Manager
	 	  	South County Business Park
	 	  	Leopardstown
	 	  	Dublin 18, Ireland
	 	  	Phone: +353 1 2912081
	 	  	Fax: +353 1 2955726
	 	  	Email: fleminga@iconirl.com

  
 or to such other designation as either
party may hereafter notify the other in accordance with other provisions in this Section. This Notices section is not intended to govern day-to-day business communications necessary for the performance of routine duties arising under a separate
Project Contract. 
  
 8.4 Delivery: All such notices or
other communications shall be deemed to have been served as follows: 
  

	 	(a)	if delivered personally, at the time of such delivery; or 

  

	 	(b)	if sent by first-class pre-paid U.S. Mail, three business days (Saturday, Sundays and Bank or other public holidays excluded) after being postmarked; or 

  

	 	(c)	if sent by overnight delivery service, the next business day; or 

  

 14 

	 	(d)	if sent by facsimile three business days after the postal confirmation has been postmarked. 

  
 8.5 Modification & Waiver: No modification of this Master Agreement or any Project Contract shall be deemed
effective unless in writing and signed by each of the parties hereto, and no waiver of any right set forth herein shall be deemed effective unless in writing and signed by the party against whom enforcement of the waiver is sought. 
  
 8.6 Severability: If any provision of this Master Agreement or any
Project Contract or portion thereof is held to be unenforceable or invalid by a court of competent jurisdiction, the validity and enforceability of the enforceable portion of any such provision and/or the remaining provisions shall not be affected
thereby. 
  
 8.7 Integration of Master Agreement: This
Master Agreement represents the entire agreement between the parties and supersedes all prior negotiations, representations or agreements, written or oral, regarding the terms described herein. All exhibits and addenda attached hereto shall be
deemed to be fully incorporated into this Master Agreement. Additionally, each Project Contract negotiated pursuant to this Master Agreement is incorporated into and made part of this Master Agreement by reference. 
  
 8.8 Descriptive Headings: The descriptive headings of the sections of
this Master Agreement and all Project Contracts are inserted for convenience only and shall not control or affect the meaning or construction of any provision hereof. 
  
 8.9 Force Majeure: Neither party shall be liable for any failure to perform or delay in performing any obligations
under this Master Agreement if such failure or delay is due to fire, flood, earthquake, strike or any other industrial disturbance, war (declared or undeclared), embargo, blockade, legal prohibition, riot, insurrection or any other cause beyond the
control of such defaulting party preventing or delaying the performance of such obligations; provided that such obligations shall be performed immediately upon the termination of such cause and provided further that in the event of such failure or
delay continuing for more than forty five (45) days either party may, without incurring liability to the other, terminate this Master Agreement or the applicable Project Contract immediately by written notice to the other party. 
  
 8.10 Use of Name: Each party, on behalf of itself, its employees and
agents, agrees not to use the name of the other party or its employees or agents in any publication, promotional material or other written or oral statement for public distribution, relative to the subject matter or existence of this Master
Agreement or any Project Contract, except as otherwise required by applicable law, regulations, guidelines and standards, as previously consented to in writing by the other party, or for NTI’s regulatory filings or correspondence with respect
to product the subject of Services provided by ICON. 
  
 8.11
Governing Law: This Master Agreement and all Project Contracts shall in all respects (including the formation thereof and performance thereunder), be governed by and construed in accordance with the laws in force in New York. 
  
 8.12 Counterparts: This Master Agreement may be executed in two (2)
counterparts each of which shall be deemed an original, but both of which together shall constitute one and 

  

 15 

 
the same instrument. This Master Agreement shall not be binding until ICON receives a signed original from NTI. 
  

	9.	DISPUTE RESOLUTION: 

  
 9.1 Dispute Resolution: The appropriate contract managers or other designated individuals representing both parties shall meet and attempt in good
faith to settle any dispute, claim or controversy arising out of or relating to the interpretation, performance or breach of this Master Agreement (the “Dispute”). However, if the contract managers fail to resolve the Dispute within
ten (10) business days (the “Initial Period”), then such Dispute shall be referred for resolution to a designated senior executive of each party who has the authority to settle the Dispute but who is not directly involved in the
Dispute. The designated senior executive of each party shall attempt in good faith to settle such Dispute within thirty (30) days from the date the disputing party receives the above written response. Notwithstanding anything herein to the contrary,
nothing in this section shall preclude either party from seeking interim or provisional relief, including, without limitation, a temporary restraining order, preliminary injunction or other interim equitable relief concerning a Dispute if necessary
to protect the interests of such party. 
  
 9.2
Arbitration: All Disputes between ICON and NTI arising from their dealings under this Master Agreement (either during or after the term of this Master Agreement) and not resolved by the methods defined in Section 9.1 of this Master Agreement,
shall be settled by binding Arbitration in New York City, under the rules of the American Arbitration Association. 
  
 IN WITNESS WHEREOF, the parties hereto have caused this Master Agreement to be duly executed by their authorized representatives as of the dates
written below. 
  

									
	ICON Clinical Research, L.P.	 	 	 	Neurobiological Technologies, Inc.
					
	 Signed: 
	 	 /s/ Richard D. Malcolm
	 	 	 	 Signed: 
	 	 /s/ Lisa Carr

	 	 	 Richard D. Malcolm, Ph.D.
 Vice President, Business Development
	 	 	 	 	 	 Lisa Carr, M.D., Ph.D.
 Vice President, Medical Affairs

					
	 Date:
	 	 4/19/04
	 	 	 	 Date:
	 	 4/27/04

  

 16 

  
 SAMPLE PROJECT CONTRACT

  
 ATTACHMENT A 
  
 This Project Contract is entered into between Neurobiological Technologies,
Inc. (“NTI”) and ICON Clinical Research [            ], (“ICON”) as of the          day of
                    ,200   (the “Effective Date”) pursuant to the Master Services Agreement between the
parties dated as of the _,._ day of            , 2003 (the “Master Agreement”). Except as modified by this Project Contract, the terms and conditions of the Master
Agreement are incorporated herein by reference and shall govern the performance of the parties’ duties under this Project Contract. Capitalized terms used herein and not otherwise defined are used as defined in the Master Agreement. 

 
 1. Protocol. The study to be performed is entitled “_______,
Protocol Number _______” (the “Study”) and is set forth in the Protocol attached as Exhibit A and incorporated herein by reference. For purposes of this Project Contract, the Study Drug for the Study is defined as __________.

  
 2. ICON Proposal. The services to be performed by ICON
for the Study (“Services”) are set forth in the proposal attached as Exhibit B and incorporated herein by reference. 
  
 3. Costs and Payment Schedule. In consideration for ICON’s Services under this Project Contract, NTI agrees to pay ICON in accordance with the
budget set forth in the attached Exhibit C and incorporated herein by reference. The total amount payable by NTI to ICON in respect of professional fees, exclusive of pass-through expenses under this Project Contract for direct labor costs shall in
no way exceed MAXIMUM COMPENSATION ($XXXXX) without prior written consent of both parties. Pass through expenses under this Project Contract are estimated to be
$                    . 
  
 4. Transfer of Obligations. Pursuant to 21 CFR §312.52, NTI hereby transfers to ICON and ICON hereby assumes all the obligations of NTI as
sponsor of the Study as set forth in Exhibit D attached and incorporated herein by reference and included on Form FDA 1571, Section 13. NTI shall retain the right to assume any of the duties delegated to ICON at any time and the Services and Exhibit
C shall be adjusted accordingly. 
  
 5. Key Personnel. Key
Personnel under this Project Contract are named in the attached Exhibit E. 
  
 6. Term. This Project Contract shall begin as of the Effective Date and shall be completed by DATE / when all of the Services are fully performed in accordance with this Project Contract, unless terminated
earlier pursuant to the Master Agreement. 
  
 [Note: Include any
other terms and conditions that may be required which are specific to this study.] 
  

 17 

 7. Notices. Unless otherwise directed in writing by the receiving party, day-to-day correspondence
relating to this Project Contract shall be delivered in accordance with the Master Agreement and addressed as follows: 
  

			
	If to NTI:	  	Neurobiological Technologies, Inc.
	 	  	Attn: Heather McLaughlin
	 	  	Clinical Project Manager
	 	  	3260 Blume Drive, Suite 500
	 	  	Richmond, CA 94806
	 	  	Phone: 510-262-1730
	 	  	Fax: 510-262-0204
	 	  	Email: heatherm@ntii.com
		
	If to ICON:	  	ICON Clinical Research, L.P.
	 	  	Katie Ruane
	 	  	Contract Associate - Business Development
	 	  	212 Church Road
	 	  	North Wales, PA 19454
	 	  	Phone: 215-616-3641
	 	  	Fax: 215-616-3095
	 	  	Email: ruanek@iconus.com
		
	With a copy to:	  	ICON Clinical Research, L.P.
	 	  	Claudia Kunzler
	 	  	Director, Business Development
	 	  	555 Twin Dolphin Drive, Suite 400
	 	  	Redwood City, CA 94065
	 	  	Phone: (650) 369-8399
	 	  	Fax: (650) 591-0611
	 	  	Email: kunzlerc@iconus.com

  
 8. Invoices and
Payments. All ICON invoices should be forwarded to NTI NAME as follows: 
  

			
	 	  	Attn: Heather McLaughlin
	 	  	Clinical Project Manager
	 	  	3260 Blume Drive, Suite 500
	 	  	Richmond, CA 94806
	 	  	Phone: 510-262-1730
	 	  	Fax: 510-262-0204
	 	  	Email: heatherm@ntii.com

  
 All payments should be
forwarded to ICON pursuant to Project Specific Details to be Entered Here. 
  

			
	 	  	ICON Clinical Research, L.P.
	 	  	Attn.: David Peters, Vice President of Finance
	 	  	P.O. Box 82-8268
	 	  	Philadelphia, PA 19182-8268
	 	  	Tax I.D. Number: 52-2133696

  

 18 

 9. Exhibits. The Exhibits attached hereto form an integral part of this Project Contract and are
hereby incorporated by reference. 
  
 10. Entire Agreement.
With respect to the Services performed under this Project Contract, this Project Contract, including the attached Exhibits, and the Master Agreement contain the entire agreement of the parties. Any modifications to this Project Contract must be in
writing and signed by the parties. 
  
 IN WITNESS WHEREOF, the
parties hereto have executed this Project Contract as of the dates stated below. 
  

									
	ICON Clinical Research, L.P.	 	 	 	Neurobiological Technologies, Inc.
					
	 By:
	 	 	 	 	 	 By:
	 	 
	 	 	 Richard D. Malcolm, Ph.D.
	 	 	 	 Printed Name:
	 	 
	 	 	 Vice President, Business Development
	 	 	 	 Title:
	 	 
	 	 	 	 	 	 	 	 	 
					
	 Date:
	 	 	 	 	 	 Date:
	 	 

  

 19 

  
 Exhibit A

 Protocol 
  
 Exhibit B 
 Proposal 

 
 Exhibit C 
 Cost and Payment Schedule 
  
 Exhibit D 
 Transfer of
Obligations 
  
 Neurobiological Technologies, Inc., as sponsor of
the Protocol/ Project Contract, hereby transfers responsibilities for the following obligations and ICON Clinical Research, L. P. hereby assumes such obligations, in accordance with 21 C.F.R. section 312.52. 
  
 Exhibit E 
 Key PersonnelOffice Lease

 Exhibit 10.5 
  
 WATERGATE OFFICE TOWERS 
 EMERYVILLE TOWER III 
 EMERYVILLE, CALIFORNIA 
  
 OFFICE LEASE AGREEMENT 
  
 BETWEEN 
  
 CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership 
 (“LANDLORD”) 
  
 AND NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware 
 corporation

 (“TENANT”) 
  

 OFFICE LEASE AGREEMENT 
  
 THIS OFFICE LEASE AGREEMENT (the “Lease”) is made and entered into as of the 22nd day of April, 2005, by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited
partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware corporation (“Tenant”). The following exhibits and attachments are incorporated into and made a part of the Lease:
Exhibit A (Outline and Location of Premises), Exhibit B (Expenses and Taxes), Exhibit C (Work Letter), Exhibit D (Commencement Letter), Exhibit E (Building Rules and Regulations), Exhibit F (Additional
Provisions) and Exhibit G (Parking Agreement). 
  

	1.	Basic Lease Information. 

  

	 	1.01	“Building” shall mean the building located at 2000 Powell Street, Emeryville, California, commonly known as Emeryville Tower III. “Rentable Square Footage
of the Building” is deemed to be 367,793 square feet. 

  

	 	1.02	“Premises” shall mean the area shown on Exhibit A to this Lease. The Premises is located on the 8th floor and known as suite 800. If the Premises include one
or more floors in their entirety, all corridors and restroom facilities located on such full floor(s) shall be considered park of the Premises. The “Rentable Square Footage of the Premises” is deemed to be 9,650 square feet.
Landlord and Tenant stipulate and agree that the Rentable Square Footage of the Building and the Rentable Square Footage of the Premises are correct. 

  

	 	1.03	“Base Rent”: 

  

							
	 Period or Months of Term

	  	 Annual Rate Per
 Square Foot

	  	Monthly Base Rent

	 1 – 12
	  	$	22.80	  	$	18,335.00
	 13 – 24
	  	$	23.52	  	$	18,914.00
	 25 – 36
	  	$	24.24	  	$	19,493.00
	 37 – 48
	  	$	24.96	  	$	20,072.00
	 49 – 60
	  	$	25.68	  	$	20,651.00
	 61 – 63
	  	$	26.40	  	$	21,230.00

  
 Notwithstanding
anything contained in the Lease to the contrary, as long as Tenant is not in default beyond any applicable cure period under the terms of the Lease, Tenant shall be entitled to an abatement of Base Rent in the amount of $18,335.00 per month for 3
consecutive full calendar months of the Lease Term, beginning with the 1st full calendar month of the Lease Term
(the “Initial Base Rent Abatement Period”). The total amount of Base Rent abated during the Initial Base Rent Abatement Period shall equal $55,005.00 (the “Initial Abated Base Rent”). In the event Tenant is
in default beyond any applicable cure period 
  

 at any time during the Lease Term or any extensions thereof, all Initial Abated Base Rent shall
immediately become due and payable. The payment by Tenant of the Initial Abated Base Rent in the event of a default shall not limit or affect any of Landlord’s other rights, pursuant to this Lease or at law or in equity. During the Initial Base
Rent Abatement Period, only Base Rent shall be abated, and all Additional Rent and other costs and charges specified in this Lease shall remain as due and payable pursuant to the provisions of this Lease. 
  
 Notwithstanding anything contained in the Lease to the contrary, as long as
Tenant is not in default beyond any applicable cure period under the terms of the Lease, Tenant shall be entitled to an additional abatement of Base Rent in the amount of $18,914.00 per month for 2 consecutive full calendar months of the Lease Term,
beginning with the 13th full calendar month of the Lease Term (the “Second Base Rent
Abatement Period”). The total amount of Base Rent abated during the Second Base Rent Abatement Period shall equal $37,828.00 (the “Second Abated Base Rent”). In the event Tenant is in default beyond any applicable
cure period at any time during the Lease Term or any extensions thereof, the Second Abated Base Rent shall immediately become due and payable. The payment by Tenant of the Second Abated Base Rent in the event of a default shall not limit or affect
any of Landlord’s other rights, pursuant to this Lease or at law or in equity. During the Second Base Rent Abatement Period, only Base Rent shall be abated, and all Additional Rent and other costs and charges specified in this Lease shall
remain as due and payable pursuant to the provisions of this Lease. 
  

	 	1.04	“Tenant’s Pro Rata Share”: 2.6237%. 

  

	 	1.05	“Base Year” for Taxes (defined in Exhibit B): 2005; “Base Year” for Expenses (defined in Exhibit B): 2005.

  

	 	1.06	“Term”: A period of 63 months and 0 days. Subject to Section 3, the Term shall commence on July 1, 2005 (the “Commencement Date”) and, unless
terminated early in accordance with this Lease, end on September 30, 2010 (the “Termination Date”). 

  

	 	1.07	“Allowance(s)”: None. 

  

	 	1.08	“Security Deposit”: $52,000.00, subject to reduction as more fully described in Section 6. 

  

	 	1.09	“Guarantor(s)”: There are no Guarantors at this time. 

  

	 	1.10	“Broker(s)”: Alan Bernier of Aegis Realty Partners. 

  

	 	1.11	“Permitted Use”: General office use; provided that in no event shall the Premises, or any portion of the Premises, be used for the operation of (i) a quick printing
business; and (ii) a full table service, sit-down restaurant selling Mexican food and/or South American style food. 

  

 3 

  

	 	1.12	“Notice Address(es)”: 

  

			
	Landlord:	  	Tenant:
		
	CA-Emeryville Properties Limited Partnership	  	(The Premises)
	c/o Equity Office Management, L.L.C.	  	 
	One Market, Spear Tower, Suite 600	  	 
	San Francisco. California 94105	  	 
	Attn: Property Manager	  	 

  
 A copy of any notices
to Landlord shall be sent to Equity Office, One Market, Spear Tower, Suite 600, San Francisco, California 94105, Attn: San Francisco Regional Counsel. 
  

	 	1.13	“Business Day(s)” are Monday through Friday of each week, exclusive of New Year’s Day, Presidents Day, Memorial Day, Independence Day, Labor Day, Thanksgiving
Day and Christmas Day (“Holidays”). Landlord may designate additional Holidays that are commonly recognized by other office buildings in the area where the Building is located. “Building Service Hours” are 8:00 a.m.
to 6:00 p.m. on Business Days. 

  

	 	1.14	“Landlord Work” means the work, if any, that Landlord is obligated to perform in the Premises pursuant to a separate agreement (the “Work Letter”),
if any, attached to this Lease as Exhibit C. 

  

	 	1.15	“Property” means the Building and the parcel(s) of land on which it is located and, at Landlord’s discretion, the parking facilities and other improvements, if
any, serving the Building and the parcel(s) of land on which they are located. 

  

	2.	Lease Grant. 

  
 The Premises are hereby leased to Tenant from Landlord, together with the right to use any portions of the Property that are designated by Landlord for
the common use of tenants and others (the “Common Areas”). 
  

	3.	Adjustment of Commencement Date; Possession. 

  

	 	3.01	If Landlord is required to perform Landlord Work prior to the Commencement Date: (a) the date set forth in Section 1.06 as the Commencement Date shall instead be defined as the
“Target Commencement Date”; (b) the actual Commencement Date shall be the date on which the Landlord Work is Substantially Complete (defined below); and (c) the Termination Date will be the last day of the Term as determined based
upon the actual Commencement Date. Landlord’s failure to Substantially Complete the Landlord Work by the Target Commencement Date shall not be a default by Landlord or otherwise render 

  

 4 

 Landlord liable for damages. Promptly after the determination of the Commencement Date, Landlord and
Tenant shall enter into a commencement letter agreement in the form attached as Exhibit D. Tenant’s failure to execute and return the commencement letter, or to provide written objection to the statements contained in the letter, within
30 days after the date of the letter shall be deemed an approval by Tenant of the statements contained therein. If the Termination Date does not fall on the last day of a calendar month, Landlord and Tenant may elect to adjust the Termination Date
to the last day of the calendar month in which the Termination Date occurs by the mutual execution of a commencement letter agreement setting forth such adjusted date. The Landlord Work shall be deemed to be “Substantially Complete”
on the date that all Landlord Work has been performed, other than any details of construction, mechanical adjustment or any other similar matter, the non-completion of which does not materially interfere with Tenant’s use of the Premises. If
Landlord is delayed in the performance of the Landlord Work as a result of the acts or omissions of Tenant, the Tenant Related Parties (defined in Section 13) or their respective contractors or vendors, including, without limitation, changes
requested by Tenant to approved plans, Tenant’s failure to comply with any of its obligations under this Lease, or the specification of any materials or equipment with long lead times (a “Tenant Delay”), the Landlord Work shall
be deemed to be Substantially Complete on the date that Landlord could reasonably have been expected to Substantially Complete the Landlord Work absent any Tenant Delay. 
  

	 	3.02	If the Commencement Date has not occurred on or before the Outside Completion Date (defined below), Tenant shall be entitled to a rent abatement following the Commencement Date of
$611.60 for every day in the period beginning on the Outside Completion Date and ending on the Commencement Date. The “Outside Completion Date” shall mean the date which is 120 days after the later of the date this Lease is properly
executed and delivered by Tenant, the date all prepaid rental, and Security Deposits and Guaranties required sunder this Lease are delivered to Landlord. Landlord and Tenant acknowledge and agree that: (i) the determination of the Commencement Date
shall take into consideration the effect of any Tenant Delays by Tenant; and (ii) the Outside Completion Date shall be postponed by the number of days the Commencement Date is delayed due to events of Force Majeure. 

  

	 	3.03	Subject to Landlord’s obligation, if any, to perform Landlord Work, the Premises are accepted by Tenant in “as is” condition and configuration without any
representations or warranties by Landlord. By taking possession of the Premises, Tenant agrees that the Premises are in good order and satisfactory condition. Landlord shall not be liable for a failure to deliver possession of the Premises or any
other space due to the holdover or unlawful possession of such space by another party, however Landlord shall use reasonable efforts to obtain possession of the space. The commencement date for the space, in such event, shall be postponed until the
date Landlord delivers possession of the Premises to Tenant free from occupancy by any party. If Tenant takes possession of the Premises before the Commencement Date, such possession shall be subject to the terms and 

  

 5 

 conditions of this Lease and Tenant shall pay Rent (defined in Section 4.01) to Landlord for each day of
possession before the Commencement Date. However, except for the cost of services requested by Tenant (e.g., freight elevator usage), Tenant shall not be required to pay Rent for any days of possession before the Commencement Date during which
Tenant, with the approval of Landlord, is in possession of the Premises for the sole purpose of performing improvements or installing furniture, equipment or other personal property. 
  

	4.	Rent. 

  

	 	4.01	Tenant shall pay Landlord, without any setoff or deduction, unless expressly set forth in this Lease, all Base Rent and Additional Rent due for the Term (collectively referred to as
“Rent”). “Additional Rent” means all sums (exclusive of Base Rent) that Tenant is required to pay Landlord under this Lease. Tenant shall pay and be liable for all rental, sales and use taxes (but excluding income
taxes), if any, imposed upon or measured by Rent. Base Rent and recurring monthly charges of Additional Rent shall be due and payable in advance on the first day of each calendar month without notice or demand, provided that the installment of Base
Rent for the fourth full calendar month of the Term, and the first monthly installment of Additional Rent for Expenses and Taxes, shall be payable upon the execution of this Lease by Tenant. All other items of Rent shall be due and payable by Tenant
on or before 30 days after billing by Landlord. Rent shall be made payable to the entity, and sent to the address, Landlord designates and shall be made by good and sufficient check or by other means acceptable to Landlord. Tenant shall pay Landlord
an administration fee equal to 5% of all past due Rent, provided that Tenant shall be entitled to a grace period of 5 days for the first 2 late payments of Rent in a calendar year. In addition, past due Rent shall accrue interest at 12% per annum.
Landlord’s acceptance of less than the correct amount of Rent shall be considered a payment on account of the earliest Rent due. Rent for any partial month during the Term shall be prorated. No endorsement or statement on a check or letter
accompanying payment shall be considered an accord and satisfaction. Tenant’s covenant to pay Rent is independent of every other covenant in this Lease. 

  

	 	4.02	Tenant shall pay Tenant’s Pro Rata Share of Taxes and Expenses in accordance with Exhibit B of this Lease. 

  

	5.	Compliance with Laws; Use. 

  
 The Premises shall be used for the Permitted Use and for no other use whatsoever. Tenant shall comply with all statutes, codes, ordinances, orders, rules
and regulations of any municipal or governmental entity whether in effect now or later, including the Americans with Disabilities Act (“Law(s)”), regarding the operation of Tenant’s business and the use, condition,
configuration and occupancy of the Premises. in addition, Tenant shall, at its sole cost and expense, promptly comply with any Laws that relate to the “Base Building” (defined below), but only to the extent such obligations are triggered
by Tenant’s use of the Premises, other than for general office use, or Alterations or improvements in the Premises performed or requested by 
  

 6 

 Tenant. “Base Building” shall include the structural portions of the Building, the public restrooms and
the Building mechanical, electrical and plumbing systems and equipment located in the internal core of the Building on the floor or floors on which the Premises are located. Tenant shall promptly provide Landlord with copies of any notices it
receives regarding an alleged violation of Law. Tenant shall comply with the rules and regulations of the Building attached as Exhibit E and such other reasonable rules and regulations adopted by Landlord from time to time, including rules
and regulations for the performance of Alterations (defined in Section 9). 
  

	6.	Security Deposit. 

  
 The Security Deposit shall be delivered to Landlord upon the execution of this Lease by Tenant and held by Landlord without liability for interest (unless
required by Law) as security for the performance of Tenant’s obligations. The Security Deposit is not an advance payment of Rent or a measure of damages. Landlord may use all or a portion of the Security Deposit to satisfy past due Rent, to
cure any Default (defined in Section 18) by Tenant, or to satisfy any other loss or damage resulting from Tenant’s Default as provided in Section 19. if Landlord uses any portion of the Security Deposit, Tenant shall, within 5 days after
demand, restore the Security Deposit to its original amount. Landlord shall return any unapplied portion of the Security Deposit to Tenant within 45 days after the later to occur of: (a) determination of the final Rent due from Tenant; or (b) the
later to occur of the Termination Date or the date Tenant surrenders the Premises to Landlord in compliance with Section 25. Landlord may assign the Security Deposit to a successor or transferee and, following the assignment, Landlord shall have no
further liability for the return of the Security Deposit. Landlord shall not be required to keep the Security Deposit separate from its other accounts. Tenant hereby waives the provisions of Section 1950.7 of the California Civil Code, or any
similar or successor Laws now or hereinafter in effect. 
  

	 	6.01	Subject to the remaining terms of this Section 6, and provided Tenant has timely paid all Rent due under this Lease during the 12 month period immediately preceding the effective
date of any reduction of the Security Deposit and can demonstrate a net worth equal to or greater than Tenant’s net worth as of the date of this Lease (with evidence reasonably satisfactory to Landlord), Tenant shall have the right to reduce
the amount of the Security Deposit so that the new Security Deposit amount will be $35,000.00 effective as of the first anniversary of the Commencement Date. Notwithstanding anything to the contrary contained herein, if Tenant has been in
default at any time prior to the effective date of any reduction and has failed to cure such default within any applicable cure period, then Tenant shall have no further right to reduce the amount of the Security Deposit as described herein.

  

	 	6.02	If Tenant is entitled to a reduction in the Security Deposit, Tenant shall provide Landlord with written notice requesting that the Security Deposit be reduced as provided above
(the “Reduction Notice”). If Tenant provides Landlord with a Reduction Notice, and Tenant is entitled to reduce the Security Deposit as provided herein, Landlord shall refund the applicable portion of the Security Deposit to Tenant
within 45 days after the later to occur of (a) Landlord’s receipt of the Reduction Notice, or (b) the date upon which Tenant is entitled to a reduction is the Security Deposit as provided above. 

  

 7 

	7.	Building Services. 

  

	 	7.01	Landlord shall furnish Tenant with the following services: (a) water for use in the Base Building lavatories; (b) customary heat and air conditioning in season during Building
Service Hours, although Tenant shall have the right to receive HVAC service during hours other than Building Service Hours by paying Landlord’s then standard charge for additional HVAC service and providing such prior notice as is reasonably
specified by Landlord; (c) standard janitorial service on Business Days; (d) elevator service; (a) electricity in accordance with the terms and conditions in Section 7.02; (f) access to the Building for Tenant and its employees 24 hours per day/7
days per week, subject to the terms of this Lease and such protective services or monitoring systems, if any, as Landlord may reasonably impose, including, without limitation, sign-in procedures and/or presentation of identification cards; and (g)
such other services as Landlord reasonably determines are necessary or appropriate for the Property. As of the date hereof, landlord’s charge for after hours heating and air conditioning service is $35.00 per hour, subject to change from time
to time. 

  

	 	7.02	Electricity used by Tenant in the Premises shall, at Landlord’s option, be paid for by Tenant either: (a) through inclusion in Expenses (except as provided for excess usage);
(b) by u separate charge payable by Tenant to Landlord; or Q by separate charge billed by the applicable utility company and payable directly by Tenant. Without the consent of Landlord, Tenant’s use of electrical service shall not exceed,
either in voltage, rated capacity, use beyond Building Service Hours or overall !8&d’ that which Landlord reasonably deems to be standard for the Building. Landlord shall have the right to measure electrical usage by commonly accepted
methods, including the installation of measuring devices such as submeters and check meters. If it is determined that Tenant is using excess electricity, Tenant shall pay Landlord Additional Rent for 1h8 cost of such excess electrical usage and for
the cost of purchasing and installing the measuring device(s). 

  

	 	7.03	Landlord’s failure to furnish, or any interruption, diminishment or termination of services due to the application of Laws, the failure of any equipment, the performance of
repairs, improvement or alternations, utility interruptions r the occurrence of an event of Force Majeure (defined in Section 26.03) (collectively a “Service Failure”) shall not render Landlord liable to Tenant, constitute a
constructive eviction of Tenant, give rise to an abatement of Rent, nor relieve Tenant from the obligation to fulfill any covenant or agreement. However, if the Premises, or a material portion of the Premises, are made untenantable for a period in
excess of 3 consecutive Business Days as a result of a Service Failure that is reasonably within the control of Landlord to correct, then Tenant, as its sole remedy, shall be entitled to receive an abatement of Rent payable hereunder during the
period beginning on the 4th consecutive Business 

  

 8 

 Day of the Service Failure and ending on the day the service has been restored. If the entire Premises
have not been rendered untenantable by the Service Failure, the amount of abatement shall be equitably prorated. 
  

	8.	Leasehold Improvements. 

  
 All improvements in and to the Premises, including any Alterations (defined in Section 9.03) (collectively, “Leasehold Improvements”)
shall remain upon the Premises at the end of the Term without compensation to Tenant, provided that Tenant, at its expense, in compliance with the National Electric Code or other applicable Law, shall remove any Cable (defined in Section 9.01
below). In addition, Landlord, by written notice to Tenant at least 30 days prior to the Termination Date, may require Tenant, at its expense, to remove any Landlord Work or Alterations that, in Landlord’s reasonable judgment, are of a nature
that would require removal and repair costs that are materially in excess of the removal and repair costs associated with standard office improvements (the Cable and such other items collectively are referred to as “Required
Removables”). Required Removables shall include, without limitation, internal stairways, raised floors, personal baths and showers, vaults, rolling file systems and structural alterations and modifications. The Required Removables shall be
removed by Tenant before the Termination Date. Tenant shall repair damage caused by the installation or removal of Required Removables. If Tenant fails to perform its obligations in a timely manner, Landlord may perform such work at Tenant’s
expense. Tenant, at the time it requests approval for a proposed Alteration, including any Initial Alterations or Landlord Work, as such terms may be defined in the Work Letter attached as Exhibit C, may request in writing that Landlord
advise Tenant whether the Alteration, including any Initial Alterations or Landlord Work, or any portion thereof, is a Required Removable. Within 10 days after receipt of Tenant’s request, Landlord shall advise Tenant in writing as to which
portions of the alteration or other improvements are Required Removables. Notwithstanding the foregoing, Tenant shall not be required to remove any portion of the Landlord Work shown on the Plans as of the date of this Lease, as such terms are
defined in Exhibit C. 
  

	9.	Repairs and Alterations. 

  

	 	9.01	Tenant shall periodically inspect the Premises to identify any conditions that are dangerous or in need of maintenance or repair. Tenant shall promptly provide Landlord with notice
of any such conditions. Tenant shall, at its sole cost and expense, perform all maintenance and repairs to the Premises that are not Landlord’s express responsibility under this Lease, and keep the Premises in good condition and repair,
reasonable wear and tear excepted. Tenant’s repair and maintenance obligations include, without limitation, repairs to: (a) floor covering; (b) interior partitions; (c) doors; (d) the interior side of demising walls; (e) electronic, fiber,
phone and data cabling and related equipment that is installed by or for the exclusive benefit of Tenant (collectively, “Cable”); (f) supplemental air conditioning units, kitchens, including hot water heaters, plumbing, and similar
facilities exclusively serving Tenant; and (g) Alterations. Subject to the terms of Section 15 below, to the extent Landlord is not reimbursed by insurance proceeds, Tenant shall reimburse Landlord for the cost of repairing damage to the Budding
caused by the act of Tenant, Tenant Related Parties and their respective 

  

 9 

 contractors and vendors. If Tenant fails to make any repairs to the Premises for more than 15 days after
notice from Landlord (although notice shall not be required in an emergency), Landlord may make the repairs, and Tenant shall pay the reasonable cost of the repairs, together with an administrative charge in an amount equal to 10% of the cost of the
repairs. 
  

	 	9.02	Landlord shall keep and maintain in good repair and working order and perform maintenance upon the: (a) structural elements of the Building; (b), mechanical (including HVAC),
electrical, plumbing and fire/life safety systems serving the Building in general; (c) Common Areas; (d) roof of the Building; (e) exterior windows of the Building; and (f) elevators serving the Building, Landlord shall promptly make repairs [or
which Landlord is responsible. Tenant hereby waives any and all rights under and benefits of subsection 1 of Section 1932, and Sections 1941 and 1942 of the California Civil Code, or any similar or successor Laws now or hereinafter in effect.

  

	 	9.03	Tenant shall not make alterations, repairs, additions 0[improvements 0[install any Cable (collectively referred to as “Alterations”) without first obtaining the
written consent of Landlord in each instance, which consent shall not be unreasonably withheld or delayed. However, Landlord’s consent shall not he required for any Alteration that satisfies all of the following criteria (a “Cosmetic
Alteration”): (a) is of a cosmetic nature such as painting, wallpapering, hanging pictures and installing carpeting; (b) is not visible from the exterior of the Premises or Building; (c) will not affect the Base Building; and (d) does not
require work to be performed inside the walls or above the ceiling of the Premises. Cosmetic Alterations shall he subject to all the other provisions of this Section 9.03. Prior to starting work, Tenant shall furnish Landlord with plans and
specifications; names of contractors reasonably acceptable to Landlord (provided that Landlord may designate specific contractors with respect to Base Building); required permits and approvals; evidence of contractor’s and subcontractor’s
insurance in amounts reasonably required by Landlord and naming Landlord as an additional insured; and any security for performance in amounts reasonably required by Landlord. Changes to the plans and specifications must also be submitted to
Landlord for its approval. Alterations shall be constructed in a good and workmanlike manner using materials of a quality reasonably approved by Landlord. Tenant shall reimburse Landlord for any sums paid by Landlord for third-party examination of
Tenant’s plans for non-Cosmetic Alterations. In addition, Tenant shall pay Landlord a fee for Landlord’s oversight and coordination of any non-Cosmetic Alterations equal to 10% of the cost of the non-Cosmetic Alterations. Upon completion,
Tenant shall furnish “as-built” plans for non-Cosmetic alterations, completion affidavits and full and final waivers of lien. Landlord’s approval of an Alteration shall not be deemed a representation by Landlord that the Alteration
complies with the Law. 

  

 10 

	10.	Entry by Landlord. 

  
 Landlord may enter the Premises to inspect, show or clean the Premises or to perform or facilitate the performance of repairs, alterations or additions to
the Premises or any portion of the Building. Except in emergencies or to provide Building services, Landlord shall provide Tenant with reasonable prior verbal notice of entry and shall use reasonable efforts to minimize any interference with
Tenant’s use of the Premises. If reasonably necessary, Landlord may temporarily close all or a portion of the Premises to perform repairs, alterations and additions. However, except in emergencies, Landlord will not close the Premises if the
work can reasonably be completed on weekends and after Building Service Hours. Entry by Landlord shall not constitute a constructive eviction or entitle Tenant to an abatement or reduction of Rent. 
  

	11.	Assignment and Subletting. 

  

	 	11.01	Except in connection with a Permitted Transfer (defined in Section 11.04), Tenant shall not assign, sublease, transfer or encumber any interest in this Lease or allow any third
party to use any portion of the Premises (collectively or individually, a “Transfer”) without the prior written consent of Landlord, which consent shall not be unreasonably withheld, conditioned or delayed if Landlord does not
exercise its recapture rights under Section 11.02. If the entity(ies) which directly or indirectly controls the voting shares/rights of Tenant changes at any time, such change of ownership or control shall constitute a Transfer unless Tenant is an
entity whose outstanding stock is listed on a recognized securities exchange or if at least 80% of its voting stock is owned by another entity, the voting stock of which is so listed. Tenant hereby waives the provisions of Section 1995.310 of the
California Civil Code, or any similar or successor Laws, now or hereinafter in effect, and all other remedies, including, without limitation, any right at law or equity to terminate this Lease, on its own behalf and, to the extent permitted under
all applicable Laws, on behalf of the proposed transferee. Any Transfer in violation of this Section shall, at Landlord’s option, be deemed a Default by Tenant as described in Section 18, and shall be voidable by Landlord. In no event shall any
Transfer, including a Permitted Transfer, release or relieve Tenant from any obligation under this Lease. 

  

	 	11.02	Tenant shall provide Landlord with financial statements for the proposed transferee, a fully executed copy of the proposed assignment, sublease or other Transfer documentation and
such other information as Landlord may reasonably request. Within 15 Business Days after receipt of the required information and documentation, Landlord shall either: (a) consent to the Transfer by execution of a consent agreement in a form
reasonably designated by Landlord; (b) reasonably refuse to consent to the Transfer in writing; or (c) in the event of an assignment of this Lease or subletting of more than 20% of the Rentable Square Footage of the Premises for more than 50% of the
remaining Term (excluding unexercised options), recapture the portion of the Premises that Tenant is proposing to Transfer. If Landlord exercises its right to recapture, this Lease shall automatically be amended (or terminated if the entire Premises
is being assigned or sublet) to delete the applicable portion of the Premises effective on the 

  

 11 

 proposed effective date of the Transfer, although Landlord may require Tenant to execute a reasonable
amendment or other document reflecting such reduction or termination. Tenant shall pay Landlord a review fee of $1,500.00 for Landlord’s review of any Permitted Transfer or requested Transfer. 
  

	 	11.03	Tenant shall pay Landlord 50% of all rent and other consideration which Tenant receives as a result of a Transfer that is in excess of the Rent payable to Landlord for the portion
of the Premises and Term covered by the Transfer. Tenant shall pay Landlord for Landlord’s share of the excess within 30 days after Tenant’s receipt of the excess. Tenant may deduct from the excess, on a straight-line basis, all reasonable
and customary expenses directly incurred by Tenant attributable to the Transfer. If Tenant is in Default, Landlord may require that all sublease payments be made directly to Landlord, in which case Tenant shall receive a Credit against Rent in the
amount of Tenant’s share of payments received by Landlord. 

  

	 	11.04	Tenant may assign this Lease t8 8 successor to Tenant by purchase, merger, consolidation or reorganization (an “Ownership Change”) or assign this Lease or sublet
all or a portion of the Premises to an Affiliate without the consent of Landlord, provided that all of the following conditions are satisfied (a “Permitted Transfer”): (a) Tenant is not in Default; (b) in the event of an Ownership Change,
Tenant’s successor shall own substantially all of the assets of Tenant and have a net worth which is at least equal to Tenant’s net worth as of the day prior to the proposed Ownership Change, or in the event of a Transfer to an Affiliated
(defined below), Tenant continues to have a net worth equal or greater than Tenant’s net worth at the date of this Lease or the Affiliate has a net worth equal to Tenant’s net worth at the date of this Lease; (c) the Permitted Use does not
allow the Premises to be used for retail purposes; and (d) Tenant shall give Landlord written notice at least 15 Business Days prior to the effective date of the Permitted Transfer. Tenant’s notice to Landlord shall include information and
documentation evidencing the Permitted Transfer and showing that each of the above conditions has been satisfied. If requested by Landlord, Tenant’s successor shall sign a commercially reasonable form of assumption agreement.
“Affiliate” shall mean an entity controlled by, controlling or under common control with Tenant. 

  

	12.	Liens. 

  
 Tenant shall not permit mechanics’ or other liens to be placed upon the Property, Premises or Tenant’s leasehold interest in connection with any
work or service done or purportedly done by or for the benefit of Tenant or its transferees. Tenant shall give Landlord notice N least 15 days prior to the commencement of any work in the Premises to afford Landlord the opportunity, where
applicable, to post and record notices of non-responsibility. Tenant, within 10 days of notice from Landlord, shall fully discharge any lien by settlement, by bonding or by insuring over the lien in the manner prescribed by the applicable lien Law
and, if Tenant fails to do so, Tenant shall be deemed in Default under this Lease and, in addition to any other remedies available to Landlord as a result of such Default by Tenant, Landlord, at its option, may bond, insure over or otherwise
discharge the lien. Tenant shall reimburse Landlord for any amount paid by Landlord, including, without limitation, reasonable attorneys’ fees. 
  

 12 

	13.	Indemnity and Waiver of Claims. 

  
 Except to the extent caused by the negligence or willful misconduct of Landlord or any Landlord Related Parties (defined below), Tenant shall indemnify,
defend and hold Landlord and Landlord Related Parties harmless against and from all liabilities, obligations, damages, penalties, claims, actions, costs, charges and expenses, including, without limitation, reasonable attorneys’ fees and other
professional fees (if and to the extent permitted by Law) (collectively referred to as “Losses”), which may be imposed upon, incurred by or asserted against Landlord or any of the Landlord Related Parties by any third party and
arising out of or in connection with any damage or injury occurring in the Premises or any acts or omissions (including violations of Law) of Tenant, the Tenant Related Parties (defined below) or any of Tenant’s transferees, contractors or
licensees. Except to the extent caused by the negligence or willful misconduct of Tenant or any Tenant Related Parties, Landlord shall indemnify, defend and hold Tenant, its trustees, members, principals, beneficiaries, partners, officers,
directors, employees and agents (“Tenant Related Parties”) harmless against and from all Losses which may be imposed upon, incurred by or asserted against Tenant or any of the Tenant Related Parties by any third party and arising
out of or in connection with the acts or omissions (including violations of Law) of Landlord or the Landlord Related Parties. Tenant hereby waives all claims against and releases Landlord and its trustees, members, principals, beneficiaries,
partners, officers, directors, employees, Mortgagees (defined in Section 23) and agents (the “Landlord Related Parties”) from all claims for any injury to or death of persons, damage to property or business loss in any manner
related to (a) Force Majeure, (b) acts of third parties, (c) the bursting or leaking of any tank, water closet, drain or other pipe, (d) the inadequacy or failure of any security or protective services, personnel or equipment, or (e) any matter not
within the reasonable control of Landlord. 
  

	14.	Insurance. 

  
 Tenant shall maintain the following insurance (“Tenant’s Insurance”): (a) Commercial General Liability Insurance applicable to the
Premises and its appurtenances providing, on an occurrence basis, a minimum combined single limit of $2,000,000; (b) Property/Business Interruption Insurance written on an All Risk or Special Cause of Loss Form, including earthquake sprinkler
leakage, at replacement cost value and with a replacement cost endorsement covering all of Tenant’s business and trade fixtures, equipment, movable partitions, furniture, merchandise and other personal property within the Premises
(“Tenant’s Property”) and any Leasehold Improvements performed by or for the benefit of Tenant; (c) Workers’ Compensation Insurance in amounts required by Law; and (d) Employers Liability Coverage of at lease $1,000,000.00 per
occurrence. Any company writing Tenant’s Insurance shall have an A.M. Best rating of not less than A-VIII. All Commercial General Liability Insurance policies shall name as additional insureds Landlord (or its successors and assignees), the
managing agent for the Building (or any successor), EOP Operating Limited Partnership, Equity Office Properties Trust and their respective members, principals, beneficiaries, partners, officers, directors, employees, and agents, and other designees
Landlord and its successors as the interest of such designees shall appear. In addition, Landlord shall be named as a loss payee with respect to 
  

 13 

 Property/Business Interruption Insurance on the Leasehold Improvements. All policies of Tenant’s Insurance shall
contain endorsements that the insurer(s) shall give Landlord and its designees at least 30 days’ advance written notice of any cancellation, termination, material change or lapse of insurance. Tenant shall provide Landlord with a certificate of
insurance evidencing Tenant’s Insurance prior to ‘the earlier to occur of the Commencement Date or the date Tenant is provided with possession of the Premises, and thereafter as necessary to assure that Landlord always has current
certificates evidencing Tenant’s Insurance. So long as the same is available at commercially reasonable rates, Landlord shall maintain so called All Risk property insurance on the Building at replacement cost value as reasonably estimated by
Landlord, together with such other insurance coverage as Landlord, in its reasonable judgment, may elect to maintain. 
  

	15.	Subrogation. 

  
 Landlord and Tenant hereby waive and shall cause their respective insurance carriers to waive any and all rights of recovery, claims, actions or causes of
action against the other for any loss or damage with respect to Tenant’s Property, Leasehold Improvements, the Building, the Premises, or any contents thereof, including rights, claims, actions and causes of action based on negligence, which
loss or damage is (or would have been, had the insurance required by this Lease been carried) covered by insurance. For the purposes of this waiver, any deductible with respect to a party’s insurance shall be deemed covered by and recoverable
by such party under valid and collectable policies of insurance. 
  

	16.	Casualty Damage. 

  

	 	16.01	If all or any portion of the Premises becomes untenantable by fire or other casualty to the Premises (collectively a “Casualty”), Landlord, with reasonable
promptness, shall cause a general contractor selected by Landlord to provide Landlord and Tenant with a written estimate of the amount of time required using standard working methods to Substantially Complete the repair and restoration of the
Premises and any Common Areas necessary to provide access to the Premises (“Completion Estimate”). If the Completion Estimate indicates that the Premises or any Common Areas necessary to provide access to the Premises cannot be made
tenantable within 270 days from the date the repair is started, then either party shall have the right to terminate this Lease upon written notice to the other within 10 days after receipt of the Completion Estimate. Tenant, however, shall not have
the right to terminate this Lease if the Casualty was caused by the negligence or intentional misconduct of Tenant or any Tenant Related Parties. In addition, Landlord, by notice to Tenant within 90 days after the date of the Casualty, shall have
the right to terminate this Lease if: (1) the Premises have been materially damaged and there is less than 2 years of the Term remaining on the date of the Casualty; (2) any Mortgagee requires that the insurance proceeds be applied to the payment of
the mortgage debt; or (3) a material uninsured loss to the Building or Premises occurs. 

  

	 	16.02	If this Lease is not terminated, Landlord shall promptly and diligently, subject to reasonable delays for insurance adjustment or other matters beyond Landlord’s

  

 14 

 reasonable control, restore the Premises and Common Areas. Such restoration shall be to substantially
the same condition that existed prior to the Casualty, except for modifications required by Law or any other modifications to the Common Areas deemed desirable by Landlord. Upon notice from Landlord, Tenant shall assign or endorse over to Landlord
(or to any party designated by Landlord) all property insurance proceeds payable to Tenant under Tenant’s Insurance with respect to any Leasehold Improvements performed by or for the benefit of Tenant; provided if the estimated cost to repair
such Leasehold Improvements exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance carrier, the excess cost of such repairs shall be paid by Tenant to Landlord prior to Landlord’s commencement of repairs.
Within 15 days of demand, Tenant shall also pay Landlord for any additional excess costs that are determined during the performance of the repairs. In no event shall Landlord be required to spend more for the restoration than the proceeds received
by Landlord, whether insurance proceeds or proceeds from Tenant. Landlord shall not be liable for any inconvenience to Tenant, or injury to Tenant’s business resulting in any way from the Casualty or the repair thereof. Provided that Tenant is
not in Default, during any period of time that all or a material portion of the Premises is rendered untenantable as a result of a Casualty, the Rent shall abate for the portion of the Premises that is untenantable and not use by Tenant. 

 

	 	16.03	The provisions of this Lease, including this Section 16, constitute an express agreement between Landlord and Tenant with respect to any and all damage to, or destruction of, all or
any part of the Premises or the Property, and any Laws, including, without limitation, Sections 1932(2) and 1933(4) of the California Civil Code, with respect to any rights or obligations concerning damage or destruction in the absence of an express
agreement between the parties, and any similar or successor Laws now or hereinafter in effect, shall have no application to this Lease or any damage or destruction to all or any part of the Premises or the Property. 

  

	17.	Condemnation. 

  
 Either party may terminate this Lease if any material part of the Premises is taken or condemned for any public or quasi-public use under Law, by eminent
domain or private purchase in lieu thereof (a “Taking”). Landlord shall also have the right to terminate this Lease if there is a Taking of any portion of the Building or Property which would have a material adverse effect on
Landlord’s ability to profitably operate the remainder of the Building. The terminating party shall provide written notice of termination to the other party within 45 days after it first receives notice of the Taking. The termination shall be
effective as of the effective date of any order granting possession to, or vesting legal title in, the condemning authority. If this Lease is not terminated, Base Rent and Tenant’s Pro Rata Share shall be appropriately adjusted to account for
any reduction in the square footage of the Building or Premises. All compensation awarded for a Taking shall be the property of Landlord. The right to receive compensation or proceeds are expressly waived by Tenant, however. Tenant may file a
separate claim for Tenant’s Property and Tenant’s reasonable relocation expenses, provided the filing of the claim does not diminish the amount of Landlord’s award. If only apart of the Premises is 
  

 15 

 subject to a Taking and this Lease is not terminated, Landlord, with reasonable diligence, will restore the remaining
portion of the Premises as nearly as practicable to the condition immediately prior to the Taking. Tenant hereby waives any and all rights it might otherwise have pursuant to Section 1265.130 of the California Code of Civil Procedure, or any similar
or successor Laws. 
  

	18.	Events of Default. 

  
 In addition to any other default specifically described in this Lease, each of the following occurrences shall in a “Default”: (a)
Tenant’s failure to pay any portion of Rent when due, if the failure continues for 3 days after written notice to Tenant (“Monetary Default”); (b) Tenant’s failure (other than a Monetary Default) to comply with any term,
provision, condition or covenant of this Lease, if the failure is not cured within 10 days after written notice to Tenant provided, however, if Tenant’s failure to comply cannot reasonably he cured within 10 days, Tenant shall be allowed
additional time (not to exceed 60 days) as is reasonably necessary to cure the failure so long as Tenant begins the cure within 10 days and diligently pursues the cure to completion; (c) Tenant permits a Transfer without Landlord’s required
approval or otherwise in violation of Section 11 of this Lease; (d) Tenant or any Guarantor becomes insolvent, makes a transfer in fraud of creditors, makes an assignment for the benefit of creditors, admits in writing its inability to pay its debts
when due or forfeits or loses its right to conduct business; (e) the leasehold estate is taken by process or operation of Law; (f) in the case of any ground floor or retail Tenant, Tenant does not take possession of or abandons or vacates all or any
portion of the Premises; or (g) Tenant is in default beyond any notice and cure period under any other lease or agreement with Landlord at the Building or Property. If Landlord provides Tenant with notice of Tenant’s failure to comply with any
specific provision of this Lease on 3 separate occasions during any 12-month period, Tenant’s subsequent violation of such provision shall, at Landlord’s option, be an incurable Default by Tenant. All notices sent under this Section shall
be in satisfaction of, and not in addition to, notice required by Law. 
  

	19.	Remedies. 

  

	 	19.01	Upon the occurrence of any Default under this Lease, whether enumerated in Section 18 or not, Landlord shall have the option to pursue any one or more of the following remedies
without any notice (except as expressly prescribed herein) or demand whatsoever (and without limiting the generality of the foregoing, Tenant hereby specifically waives notice and demand for payment of Rent or other obligations, except for those
notices specifically required pursuant to the terms of Section 18 or this Section 19, and waives any and all other notices or demand requirements imposed by applicable Law): 

  
 (a) Terminate this Lease and Tenant’s right to possession of the
Premises and recover from Tenant an award of damages equal to the sum of the following: 
  
 (i) The Worth at the Time of Award of the unpaid Rent which had been earned at the time of termination; 
  

 16 

 (ii) The Worth at the Time of Award of the amount by which the unpaid Rent which would have been earned
after termination until the time of award exceeds the amount of such Rent loss that Tenant affirmatively proves could have been reasonably avoided; 
  
 (iii) The Worth at the Time of Award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds the amount of
such Rent loss that Tenant affirmatively proves could be reasonably avoided; 
  
 (iv) Any other amount necessary to compensate Landlord for all the detriment either proximately caused by Tenant’s failure to perform Tenant’s obligations under this Lease or which in the ordinary course of
things would be likely to result therefrom; and 
  
 (v) All such
other amounts in addition to or in lieu of the foregoing as may be permitted from time to time under applicable law. 
  
 The “Worth at the Time of Award” of the amounts referred to in parts (i) and (ii) above, shall be computed by allowing interest at the
lesser of a per annum rate equal to: (A) the greatest per annum rate of interest permitted from time to time under applicable law, or (B) the Prime Rate plus 5%. For purposes hereof, the “Prime Rate” shall be the per annum interest
rate publicly announced as its prime or base rate by a federally insured bank selected by Landlord in the State of California. The “Worth at the Time of Award” of the amount referred to in part (iii) above, shall be computed by
discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus 1%; 
  
 (b) Employ the remedy described in California Civil Code §1951.4 (Landlord may continue this Lease in effect after Tenant’s breach and
abandonment and recover Rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations); or 
  
 (c) Notwithstanding Landlord’s exercise of the remedy described in California Civil Code §1951.4 in respect of an event or events of default,
at such time thereafter as Landlord may elect in writing, to terminate this Lease and Tenant’s right to possession of the Premises and recover an award of damages as provided above in Paragraph 19.01(a). 
  

	 	19.02	The subsequent acceptance of Rent hereunder by Landlord shall not be deemed to be a waiver of any preceding breach by Tenant of any term, covenant or condition of this Lease other
than the failure of Tenant to pay the particular Rent so accepted, regardless of Landlord’s knowledge of such preceding breach at the time of acceptance of such Rent. No waiver by Landlord of any breach hereof shall be effective unless such
waiver is in writing and signed by Landlord. 

  

	 	19.03	TENANT HEREBY WAIVES ANY AND ALL RIGHTS CONFERRED BY SECTION 3275 OF THE CIVIL CODE OF CALIFORNIA AND BY SECTIONS 1174(c) AND 1179 OF THE CODE OF CIVIL PROCEDURE OF CALIFORNIA AND
ANY AND ALL OTHER LAWS AND RULES OF LAW FROM TIME TO TIME !N EFFECT DURING THE LEASE TERM PROVIDING THAT TENANT SHALL HAVE ANY RIGHT TO REDEEM, REINSTATE OR RESTORE THIS LEASE FOLLOWING ITS TERMINATION 

  

 17 

 BY REASON OF TENANT’S BREACH. TENANT ALSO HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW,
THE RIGHT TO TRIAL BY JURY IN ANY LITIGATION ARISING OUT OF OR RELATING TO THIS LEASE. 
  

	 	19.04	No right or remedy herein conferred upon or reserved to Landlord is intended to be exclusive of any other right or remedy, and each and every right and remedy shall be cumulative
and in addition to any other right or remedy given hereunder or now or hereafter existing by agreement, applicable law or in equity. In addition to other remedies provided in this Lease, Landlord shall be entitled, to the extent permitted by
applicable law, to injunctive relief, or to a decree compelling performance of any of the covenants, agreements, conditions or provisions of this Lease, or to any other remedy allowed to Landlord at law or in equity. Forbearance by Landlord to
enforce one or more of the remedies herein provided upon an event of default shall not be deemed or construed to constitute a waiver of such default. 

  

	 	19.05	If Tenant is in Default of any of its non-monetary obligations under the Lease, Landlord shall have the right to perform such obligations. Tenant shall reimburse Landlord for the
cost of such performance upon demand together with an administrative charge equal to 10% of the cost of the work performed by Landlord. 

  

	 	19.06	This Section 19 shall be enforceable to the maximum extent such enforcement is not prohibited by applicable law, and the unenforceability of any portion thereof shall not thereby
render unenforceable any other portion. 

  

	20.	Limitation of Liability. 

  
 NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS LEASE, THE LIABILITY OF LANDLORD (AND OF ANY SUCCESSOR LANDLORD) SHALL BE LIMITED TO THE LESSER
OF (A) THE INTEREST OF LANDLORD IN THE PROPERTY, OR (B) THE EQUITY INTEREST LANDLORD WOULD HAVE IN THE PROPERTY IF THE PROPERTY WERE ENCUMBERED BY THIRD PARTY DEBT IN AN AMOUNT EQUAL TO 70% OF THE VALUE OF THE PROPERTY. TENANT SHALL LOOK SOLELY TO
LANDLORD’S INTEREST IN THE PROPERTY FOR THE RECOVERY OF ANY JUDGMENT OR AWARD AGAINST LANDLORD OR ANY LANDLORD RELATED PARTY. NEITHER LANDLORD NOR ANY LANDLORD RELATED PARTY SHALL BE PERSONALLY LIABLE FOR ANY JUDGMENT OR DEFICIENCY, AND IN NO
EVENT SHALL LANDLORD OR ANY LANDLORD RELATED PARTY BE LIABLE TO TENANT FOR ANY LOST PROFIT, DAMAGE TO OR LOSS OF BUSINESS OR ANY FORM OF SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGE. BEFORE FILING SUIT FOR AN ALLEGED DEFAULT BY LANDLORD, TENANT SHALL
GIVE LANDLORD AND THE MORTGAGEE(S) WHOM TENANT HAS BEEN NOTIFIED HOLD MORTGAGES (DEFINED IN SECTION 23 BELOW), NOTICE AND REASONABLE TIME TO CURE THE ALLEGED DEFAULT. 
  

 18 

	21.	Intentionally Omitted. 

  

	22.	Holding Over. 

  
 If Tenant fails to surrender all or any part of the Premises at the termination of this Lease, occupancy of the Premises after termination shall be that
of a tenancy at sufferance. Tenant’s occupancy shall be subject to all the terms and provisions of this Lease, and Tenant shall pay an amount (on a per month basis without reduction for partial months during the holdover) equal to 150% of the
sum of the Base Rent and Additional Rent due for the period immediately preceding the holdover. No holdover by Tenant or payment by Tenant after the termination of this Lease shall be construed to extend the Term or prevent Landlord from immediate
recovery of possession of the Premises by summary proceedings or otherwise. If Landlord is unable to deliver possession of the Premises to a new tenant or to perform improvements for a new tenant as a result of Tenant’s holdover and Tenant
fails to vacate the Premises within 15 days after notice from Landlord, Tenant shall be liable for all damages that Landlord suffers from the holdover. 
  

	23.	Subordination to Mortgages; Estoppel Certificate. 

  
 Tenant accepts this Lease subject and subordinate to any mortgage(s), deed(s) of trust, ground lease(s) or other lien(s) now or subsequently arising upon
the Premises, the Building or the Property, and to renewals, modifications, refinancings and extensions thereof (collectively referred to as a “Mortgage”). The party having the benefit of a Mortgage shall be referred to as a
“Mortgagee”. This clause shall be self-operative, but upon request from a Mortgagee, Tenant shall execute a commercially reasonable subordination agreement in favor of the Mortgagee. As an alternative, a Mortgagee shall have the
right at any time to subordinate its Mortgage to this Lease. Upon request, Tenant, without charge, shall attorn to any successor to Landlord’s interest in this Lease. Landlord and Tenant shall each, within 10 days after receipt of a written
request from the other, execute and deliver a commercially reasonable estoppel certificate to those parties as are reasonably requested by the other (including a Mortgagee or prospective purchaser). Without limitation, such estoppel certificate may
include a certification as to the status of this Lease, the existence of any defaults and the amount of Rent that is due and payable. 
  

	24.	Notice. 

  
 All demands, approvals, consents or notices (collectively referred to as a “notice”) shall be in writing and delivered by hand or sent by
registered or certified mail with return receipt requested or sent by overnight or same day courier service at the party’s respective Notice Address(es) set forth in Section 1. Each notice shall be deemed to have been received on the earlier to
occur of actual delivery or the date on which delivery is refused, or, if Tenant has vacated the Premises or any other Notice Address of Tenant without providing a new Notice Address, 3 days after notice is deposited in the U.S. mail or with a
courier service in the manner described above. Either party may, at any time, change its Notice Address (other than to a post office box address) by giving the other party written notice of the new address. 
  

 19 

	25.	Surrender of Premises. 

  
 At the termination of this Lease or Tenant’s right of possession, Tenant shall remove Tenant’s Property from the Premises, and quit and
surrender the Premises to Landlord, broom clean, and in good order, condition and repair, ordinary wear and tear and damage which Landlord is obligated to repair hereunder excepted. If Tenant fails to remove any of Tenant’s Property within 2
days after termination of this Lease or Tenant’s right to possession, Landlord, at Tenant’s sole cost and expense, shall be entitled (but not obligated) to remove and store Tenant’s Property. Landlord shall not be responsible for the
value, preservation or safekeeping of Tenant’s Property. Tenant shall pay Landlord, upon demand, the expenses and storage charges incurred. If Tenant fails to remove Tenant’s Property from the Premises or storage, within 30 days after
notice, Landlord may deem all or any part of Tenant’s Property to be abandoned and title to Tenant’s Property shall vest in Landlord. 
  

	26.	Miscellaneous. 

  

	 	26.01	This Lease shall be interpreted and enforced in accordance with the Laws of the State of California and Landlord and Tenant hereby irrevocably consent to the jurisdiction and proper
venue of such state or commonwealth. If any term or provision of this Lease shall to any extent be void or unenforceable, the remainder of this Lease shall not be affected. If there is more than one Tenant or if Tenant is comprised of more than one
party or entity, the obligations imposed upon Tenant shall be joint and several obligations of all the parties and entities, and requests or demands from any one person or entity comprising Tenant shall be deemed to have been made by all such
persons or entities. Notices to any one person or entity shall be deemed to have been given to all persons and entities. Tenant represents and warrants to Landlord that each individual executing this Lease on behalf of Tenant is authorized to do so
on behalf of Tenant and that Tenant is not, and the entities or individuals constituting Tenant or which may own or control Tenant or which may be owned or controlled by Tenant are not, (i) in violation of any laws relating to terrorism or money
laundering, or (ii) among the individuals or entities identified on any list compiled pursuant to Executive Order 13224 for the purpose of identifying suspected terrorists or on the most current list published by the U.S. Treasury Department Office
of Foreign Assets Control at its official website, http://www.treas.gov/ofac/tllsdn.pdf, or any replacement website or other replacement official publication of such list. 

  

	 	26.02	If either party institutes a suit against the other for violation of or to enforce any covenant, term or condition of this Lease, the prevailing party shall be entitled to
reimbursement of all of its costs and expenses, including, without limitation, reasonable attorneys’ fees. Landlord and Tenant hereby waive any right to trial by jury in any proceeding based upon a breach of this Lease. Either party’s
failure to declare a default immediately upon its occurrence, or delay in taking action for a default, shall not constitute a waiver of the default, nor shall it constitute an estoppel. 

  

 20 

	 	26.03	Whenever a period of time is prescribed for the taking of an action by Landlord or Tenant (other than the payment of the Security Deposit or Rent), the period of time for the
performance of such action shall be extended by the number of days that the performance is actually delayed due to strikes, acts of God, shortages of labor or materials, war, terrorist acts, civil disturbances and other causes beyond the reasonable
control of the performing party (“Force Majeure”). 

  

	 	26.04	Landlord shall have the right to transfer and assign, in whole or in part, all of its rights and obligations under this Lease and in the Building and Property. Upon transfer
Landlord shall be released from any further obligations hereunder and Tenant agrees to look solely to the successor in interest of Landlord for the performance of such obligations, provided that, any successor pursuant to a voluntary, third party
transfer (but not as part of an involuntary transfer resulting from a foreclosure or deed in lieu thereof) shall have assumed Landlord’s obligations under this Lease. 

  

	 	26.05	Landlord has delivered a copy of this Lease to Tenant for Tenant’s review only and the delivery of it does not constitute an offer to Tenant or an option. Tenant represents
that it has deal directly with and only with the Broker as a broker in connection with this Lease. Tenant shall indemnify and hold Landlord and the Landlord Related Parties harmless from all claims of any other brokers claiming to have represented
Tenant in connection with this Lease. Landlord shall indemnify and hold Tenant and the Tenant Related Pates harmless from all claims of any brokers claiming to have represented Landlord in connection with this Lease. Equity Office Properties
Management Corp. (“EOPMC”) is an affiliate of Landlord and represents only the Landlord in this transaction. Any assistance rendered by any agent or employee of EOPMC in connection with this Lease or any subsequent amendment or
modification hereto has been or will be made as an accommodation to Tenant solely in furtherance of consummating the transaction on behalf of Landlord, and not as agent for Tenant. 

  

	 	26.06	Time is of the essence with respect to Tenant’s exercise of any expansion, renewal or extension rights granted to Tenant. The expiration of the Term, whether by lapse of time,
termination or otherwise, shall not relieve either party of any obligations which accrued prior to or which may continue to accrue after the expiration or termination of this Lease. 

  

	 	26.07	Tenant may peacefully have, hold and enjoy the Premises, subject to the terms of this Lease, provided Tenant pays the Rent and fully performs all of its covenants and agreements.
This covenant shall be binding upon Landlord and its successors only during its or their respective periods of ownership of the Building. 

  

	 	26.08	This Lease does not grant any rights to light or air over or about the Building. Landlord excepts and reserves exclusively to itself any and all rights not specifically granted to
Tenant under this Lease. This Lease constitutes the entire agreement between the parties and supersedes all prior agreements and understandings related to the Premises, including all lease proposals, letters of 

  

 21 

 intent and other documents. Neither party is relying upon any warranty, statement or representation not
contained in this Lease. This Lease may be modified only by a written agreement signed by an authorized representative of Landlord and Tenant. 
  
 Landlord and Tenant have executed this Lease as of the day and year first above written. 
  
 LANDLORD: 
  
 CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a 
 Delaware limited partnership 
  

					
	By:	 	EOM GP, L.L.C., a Delaware limited liability company,
its general partner
			
	 	 	 By:
	 	Equity Office Management, L.L.C., a Delaware limited liability company, its non-member manager
			
	 	 	 By:
	 	 /s/ Kenneth J. Churich

	 	 	 Name:
	 	Kenneth J. Churich
	 	 	 Title:
	 	Vice President-Leasing

  
 TENANT: 
  
 NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware 
 corporation 
  

			
	By:	 	 /s/ Paul E. Freiman

	Name:	 	Paul E. Freiman
	Title:	 	President & CEO
		
	By:	 	 /s/ Jonathan R. Wolter

	Name:	 	Jonathan R. Wolter
	Title:	 	VP & CFO

  
 Tenant Tax ID Number (SSN or FEIN):                           
                                         

  

 22 

 EXHIBIT A 
 OUTLINE AND LOCATION OF PREMISES 
  
 This Exhibit is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a
Delaware corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  
 [PROPERTY MAP] 
  

 23 

 EXHIBIT B 
 EXPENSES AND TAXES 
  
 This
Exhibit is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware
corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  

	1.	Payments. 

  

	 	1.01	Tenant shall pay Tenant’s Pro Rata Share of the amount, if any, by which Expenses (defined below) for each calendar year during the Term exceed Expenses for the Base Year (the
“Expense Excess”) and also the amount, if any, by which Taxes (defined below) for each calendar year during the Term exceed Taxes for the Base Year (the “Tax Excess”). If Expenses or Taxes in any calendar year
decrease below the amount of Expenses or Taxes for the Base Year, Tenant’s Pro Rata Share of Expenses or Taxes, as the case may be, for that calendar year shall be $0. Landlord shall provide Tenant with a good faith estimate of the Expense
Excess and of the Tax Excess for each calendar year during the Term. On or before the first day of each month, Tenant shall pay to Landlord a monthly installment equal to one-twelfth of Tenant’s Pro Rata Share of Landlord’s estimate of
both the Expense Excess and Tax Excess. After its receipt of the revised estimate, Tenant’s monthly payments shall be based upon the revised estimate. If Landlord does not provide Tenant with an estimate of the Expense Excess or the Tax Excess
by January 1 of a calendar year, Tenant shall continue to pay monthly installments based on the previous year’s estimate(s) until Landlord provides Tenant with the new estimate. 

  

	 	1.02	As soon as is practical following the end of each calendar year, Landlord shall furnish Tenant with a statement of the actual Expenses and Expense Excess and the actual Taxes and
Tax Excess for the prior calendar year. If the estimated Expense Excess or estimated Tax Excess for the prior calendar year is more than the actual Expense Excess or actual Tax Excess, as the case may be, for the prior calendar year, Landlord shall
either provide Tenant with a refund or apply any overpayment by Tenant against Additional Rent due or next becoming due, provided if the Term expires before the determination of the overpayment, Landlord shall refund any overpayment to Tenant after
first deducting the amount of Rent due. If the estimated Expense Excess or estimated Tax Excess for the prior calendar year is less than the actual Expense Excess or actual Tax Excess, as the case may be, for such prior year, Tenant shall pay
Landlord, within 30 days after its receipt of the statement of Expenses or Taxes, any underpayment for the prior calendar year. 

	2.	Expenses. 

  

	 	2.01	“Expenses” means all costs and expenses incurred in each calendar year in connection with operating, maintaining, repairing, and managing the Building and the
Property. Expenses include, without limitation: (a) all labor and labor related costs, including wages, salaries, bonuses, taxes, insurance, uniforms, training, retirement plans, pension plans and other employee benefits; (b) management fees; (c)
the cost of equipping, staffing and operating an on-site and/or off-site management office for the Building, provided if the management office services one or more other buildings or properties, the shared costs and expenses of equipping, staffing
and operating such management office(s) shall be equitably prorated and apportioned between the Building and the other buildings or properties; (d) accounting costs; (e) the cost of services; (f) rental and purchase cost of parts, supplies, tools
and equipment; (g) insurance premiums and deductibles; (h) electricity, gas and other utility costs: and (I) the amortized cost of capital improvements (as distinguished from replacement parts or components installed in the ordinary course of
business) made subsequent to the Base Year which are: (1) performed primarily to reduce current or future operating expense costs, upgrade Building security or otherwise improve the operating efficiency of the Property; or (2) required to comply
with any Laws that are enacted, or first interpreted to apply to the Property, after the date of this Lease. Landlord, by itself or through an affiliate, shall have the right to directly perform or provide any services under this Lease (including
management services as outlined above). However, in no event shall the management fees for the Building (expressed as a percentage of gross receipts for the Building) exceed the prevailing market management fees (expressed as a percentage of gross
receipts), plus 1% of such fees, for comparable third party management companies offering comparable management services in office buildings similar to the Building in class, size, age and location. The cost of capital improvements shall be
amortized by Landlord over the lesser of the Payback Period (defined below) or the useful life of the capital improvement as reasonably determined by Landlord. The amortized cost of capital improvements may, at Landlord’s option, include actual
or imputed interest at the rate that Landlord would reasonably he required to pay to finance the cost of the capital improvement. “Payback Period” means the reasonably estimated period of time that it takes for the cost savings
resulting from a capital improvement to equal the total cost of the capital improvement. Landlord, by itself or through an affiliate, shall have the right to directly perform, provide and be compensated for any services under this Lease. If Landlord
incurs Expenses for the Building or Property together with one or more other buildings or properties, whether pursuant to a reciprocal easement agreement, common area agreement or otherwise, the shared costs and expenses shall be equitably prorated
and apportioned between the Building and Property and the other buildings or properties. 

  

	 	2.02	Expenses shall not include: the cost of capital improvements (except as set forth above); depreciation; principal payments of mortgage and other non-operating debts of Landlord; the
cost of repairs or other work to the extent Landlord is 

  

 25 

 reimbursed by insurance or condemnation proceeds; costs in connection with leasing space in the
Building, including brokerage commissions; lease concessions, rental abatements and construction allowances granted to specific tenants; costs incurred in connection with the sale, financing or refinancing of the Building; fines, interest and
penalties incurred due to the late payment of Taxes or Expenses; organizational expenses associated with the creation and operation of the entity which constitutes Landlord; or any penalties or damages that Landlord pays to Tenant under this Lease
or to other tenants in the Building under their receptive leases. 
  

	 	2.03	If at any time during a calendar year the Building is not at least 95% occupied or Landlord is not supplying services to at least 95% of the total Rentable Square Footage of the
Building, Expenses shall, at Landlord’s option, be determined as if the Building had been 95% occupied and Landlord had been supplying services to 95% of the Rentable Square Footage of the Building. If Expenses for a calendar year are
determined as provided in the prior sentence, Expenses for the Base Year shall also be determined in such manner. Notwithstanding the foregoing, Landlord may calculate the extrapolation of Expenses under this Section based on 100% occupancy and
service so long as such percentage is used consistently for each year of the Term. The extrapolation of Expenses under this Section shall be performed in accordance with the methodology specified by the Building Owners and Managers Association.

  

	3.	“Taxes” shall mean: (a) all real property taxes and other assessments on the Building and/or Property, including, but not limited to, gross receipts taxes,
assessments for special improvement districts and building improvement districts, governmental charges, fees and assessments for police, fire, traffic mitigation or other governmental service of purported benefit to the Property, taxes and
assessments levied in substitution or supplementation in whole or in part of any such taxes and assessments and the Property’s share of any real estate taxes and assessments under any reciprocal easement agreement, common area agreement or
similar agreement as to the Property; (b) all personal property taxes for property that is owned by Landlord and used in connection with the operation, maintenance and repair of the Property; and (c) all costs and fees incurred in connection with
seeking reductions in any tax liabilities described in (a) and (b), including, without limitation, any costs incurred by Landlord for compliance, review and appeal of tax liabilities. Without limitation, Taxes shall not include any income, capital
levy, transfer, capital stock, gift, estate or inheritance tax. If a change in Taxes is obtained for any year of the Term during which Tenant paid Tenant’s Pro Rata Share of any Tax Excess, then Taxes for that year will be retroactively
adjusted and Landlord shall provide Tenant with a credit, if any, based on the adjustment. Likewise, if a change is obtained for Taxes for the Base Year, Taxes for the Base Year shall be restated and the Tax Excess for all subsequent years shall be
recomputed. Tenant shall pay Landlord the amount of Tenant’s Pro Rata Share of any such increase in the Tax Excess within 30 days after Tenant’s receipt of a statement from Landlord. 

  

	4.	Audit Rights. Tenant, within 365 days after receiving Landlord’s statement of Expenses, may give Landlord written notice (“Review Notice”) that Tenant
intends to review 

  

 26 

 Landlord’s records o[ the Expenses for the calendar year to which the statement applies. Within a
reasonable time after receipt of the Review Notice, Landlord shall make all pertinent records available for inspection that are reasonably necessary for Tenant to conduct its review. If any records are maintained at a location other than the
management office for the Building, Tenant may either inspect the records at such other location or pay for the reasonable cost of copying and shipping the records. If Tenant retains an agent to review Landlord’s records, the agent must be with
a CPA firm licensed to do business in the state or commonwealth where the Property is located. Tenant shall be solely responsible for all costs, expenses and fees incurred for the audit. Within 90 days after the records are made available to Tenant,
Tenant shall have the right to give Landlord written notice (an “Objection Notice”) stating in reasonable detail any objection to Landlord’s statement of Expenses for that year. If Tenant fails to give Landlord an Objection
Notice within the 90-day period or fails to provide Landlord with a Review Notice within the 365-day period described above, Tenant shall be deemed to have approved Landlord’s statement of Expenses and shall be barred from raising any claims
regarding the Expenses for that year. If Tenant provides Landlord with a timely Objection Notice, Landlord and Tenant shall work together in good faith to resolve any issues raised in Tenant’s Objection Notice. If Landlord and Tenant determine
that Expenses for the calendar year are less than reported, Landlord shall provide Tenant with a credit against the next installment of Rent in the amount of the overpayment by Tenant. Likewise, if Landlord and Tenant determine that Expenses for the
calendar year are greater than reported, Tenant shall pay Landlord the amount of any underpayment within 30 days. The records obtained by Tenant shall be treated as confidential. In no event shall Tenant be permitted to examine Landlord’s
records or to dispute any statement of Expenses unless Tenant has paid and continues to pay all Rent when due. 
  

 27 

 EXHIBIT C 
 WORK LETTER 
  
 This
Exhibit is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware
corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  
 As used in this Work Letter, the “Premises” shall be deemed to mean the Premises, as initially defined in the attached Lease. 

 

	 	1.	Landlord shall perform improvements to the Premises in accordance with the plans prepared by Brereton Architects, dated March 24, 2005, 2005 (the “Plans”). The
improvements to be performed by Landlord in accordance with the Plans are hereinafter referred to as the “Landlord Work.” It is agreed that construction of the Landlord Work will be completed at Landlord’s sole cost and expense
(subject to the terms of Section 2 below) using Building standard methods, materials and finishes. Landlord shall enter into a direct contract for the Landlord Work with a general contractor selected by Landlord. In addition, Landlord shall have the
right to select and/or approve of any subcontractors used in connection with the Landlord Work. Landlord’s supervision or performance of any work for or on behalf of Tenant shall not be deemed a representation by Landlord that such Plans or the
revisions thereto comply with applicable insurance requirements, building codes, ordinances, laws or regulations, or that the improvements constructed in accordance with the Plans and any revisions thereto will be adequate for Tenant’s use, it
being agreed that Tenant shall be responsible for all elements of the design of Tenant’s plans (including, without limitation, compliance with law, functionality of design, the structural integrity of the design, the configuration of the
premises and the placement of Tenant’s furniture, appliances and equipment). 

  

	 	2.	If Tenant shall request any revisions to the Plans, Landlord shall have such revisions prepared at Tenant’s sole cost and expense and Tenant shall reimburse Landlord for the
cost of preparing any such revisions to the Plans, plus any applicable state sales or use tax thereon, upon demand. Promptly upon completion of the revisions, Landlord shall notify Tenant in writing of the increased cost in the Landlord Work, if
any, resulting from such revisions to the Plans. Tenant, within one Business Day, shall notify Landlord in writing whether it desires to proceed with such revisions. in the absence of such written authorization, Landlord shall have the option to
continue work on the Premises disregarding the requested revision. Tenant shall be responsible for any Tenant Delay in completion of the Premises resulting from any revision to the Plans. If such revisions result in an increase in the cost of
Landlord Work, such increased costs, plus any applicable state sales or use tax thereon, shall be payable by Tenant upon demand. Notwithstanding anything herein to the contrary, all revisions to the Plans shall be subject to the approval of
Landlord. 

  

	 	3.	This Exhibit shall not be deemed applicable to any additional space added to the Premises at any time or from time to time, whether by any options under the Lease or otherwise, or
to any portion of the original Premises or any additions to the Premises in the event of a renewal or extension of the original Term of the Lease, whether by any options under the Lease or otherwise, unless expressly so provided in the Lease or any
amendment or supplement to the Lease. 

  

 29 

 EXHIBIT D 
 COMMENCEMENT LETTER 
  
 (EXAMPLE) 
  
 This Exhibit is attached to and made a part
of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware corporation (“Tenant”) for space
in the Building located at 2000 Powell Street, Emeryville, California. 
  

			
	Date	 	_____________________________
		
	Tenant	 	NEUROBIOLOGICAL TECHNOLOGIES, INC.
		
	Address	 	_____________________________
	 	 	_____________________________
	 	 	_____________________________

  

	Re:	Commencement Letter with respect to that certain Lease dated as of the      day of
            , 2005, by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership, as Landlord, and NEUROBIOLOGICAL TECHNOLOGIES, INC., a
Delaware corporation, as Tenant, for 9,650 rentable square feet on the 8th floor of the Building located at 2000 Powell Street, Emeryville, California. 

  

	    	Lease Id:
                                        
                         

 Business Unit Number:
                                        

  
 Dear
                             , 
  
 In accordance with the terms and conditions of the above referenced Lease, Tenant accepts possession of the Premises and
agrees: 
  
 1. The Commencement Date of the Lease is
                             . 
  
 2. The Termination Date of the Lease is
                                    . 
  
 Please acknowledge your acceptance of possession and agreement to the terms
set forth above by signing all 3 counterparts of this Commencement Letter in the space provided and returning 2 fully executed counterparts to my attention. Tenant’s failure to execute and return this letter, or to provide written objection to
the statements contained in this letter, within 30 days after the date of this letter shall be deemed an approval by Tenant of the statements contained herein. 
  

			
	Sincerely,
	  

	 Authorized Signatory

	
	 Agreed and Accepted:

		
	Tenant:	 	NEUROBIOLOGICAL TECHNOLOGIES, INC.,
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

  

 31 

 EXHIBIT E 
 BUILDING RULES AND REGULATIONS 
  
 This Exhibit is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC., a Delaware
corporation (“Tenant”) for in the Building located at 2000 Powell Street, Emeryville, California. 
  
 The following rules and regulations shall apply, where applicable, to the Premises, the Building, the parking facilities (if any), the Property and the
appurtenances. In the event of a conflict between the following rules and regulations and the remainder of the terms of the Lease, the remainder of the terms of the Lease shall control. Capitalized terms have the same meaning as defined in the
Lease. 
  
 1. Sidewalks, doorways, vestibules, halls, stairways
and other similar areas shall not be obstructed by Tenant or used by Tenant for any purpose other than ingress and egress to and from the Premises. No rubbish, litter, trash, or material shall be placed, emptied, or thrown in those areas. At no time
shall Tenant permit Tenant’s employees to loiter in Common Areas or elsewhere about the Building or Property. 
  
 2. Plumbing fixtures and appliances shall be used only for the purposes for which designed and no sweepings, rubbish, rags or other unsuitable material
shall be thrown or placed in the fixtures or appliances. 
  
 3. No
signs, advertisements or notices shall be painted or affixed to windows, doors or other parts of the Building, except those of such color, size, style and in such places as are first approved in writing by Landlord. All tenant identification and
suite numbers at the entrance to the Premises shall be installed by Landlord, at Tenant’s cost and expense, using the standard graphics for the Building. Except in connection with the hanging of lightweight pictures and wall decorations, no
nails, hooks or screws shall be inserted into any part of the Premises or Building except by the Building maintenance personnel without Landlord’s prior approval, which approval shall not be unreasonably withheld. 
  
 4. Landlord may provide and maintain in the first floor (main lobby) of the
Building an alphabetical directory board or other directory device listing tenants and no other directory shall be permitted unless previously consented to by Landlord in writing. 
  
 5. Tenant shall not place any lock(s) on any door in the Premises or Building without Landlord’s prior written consent,
which consent shall not be unreasonably withheld, and Landlord shall have the right at all times to retain and use keys or other access codes or devices to all locks within and into the Premises. A reasonable number of keys to the locks on the entry
doors in the Premises shall be furnished by Landlord to Tenant at Tenant’s cost and Tenant shall not make any duplicate keys. All keys shall be returned to Landlord at the expiration or early termination of the Lease. 
  
 6. All contractors, contractor’s representatives and installation
technicians performing work in the Building shall be subject to Landlord’s prior approval, which approval shall not be unreasonably withheld, and shall be required to comply with Landlord’s standard rules, regulations, policies and
procedures, which may be revised from time to time. 
  

 7. Movement in or out of the Building of furniture or office equipment, or dispatch or receipt by Tenant
of merchandise or materials requiring the use of elevators, stairways, lobby areas or loading dock areas, shall be restricted to hours reasonably designated by Landlord. Tenant shall obtain Landlord’s prior approval by providing a detailed
listing of the activity, which approval shall not be unreasonably withheld. If approved by Landlord, the activity shall be under the supervision of Landlord and performed in the manner required by Landlord. Tenant shall assume all risk for damage to
articles moved and injury to any persons resulting from the activity. If equipment, property, or personnel of Landlord or of any other party is damaged or injured as a result of or in connection with the activity, Tenant shall be solely liable for
any resulting damage, loss or injury. 
  
 8. Landlord shall have
the right to approve the weight, size, or location of heavy equipment or articles in and about the Premises, which approval shall not be unreasonably withheld. Damage to the Building by the installation, maintenance, operation, existence or removal
of Tenant’s Property shall be repaired at Tenant’s sole expense. 
  
 9. Corridor doors, when not in use, shall be kept closed. 
  
 10. Tenant shall not: (1) make or permit any improper, objectionable or unpleasant noises or odors in the Building, or otherwise interfere in any way with other tenants or persons having business with them; (2)
solicit business or distribute or cause to be distributed, in any portion of the Building, handbills, promotional materials or other advertising; or (3) conduct or permit other activities in the Building that might, in Landlord’s sole opinion,
constitute a nuisance. 
  
 11. No animals, except those assisting
handicapped persons, shall be brought into the Building or kept in or about the Premises. 
  
 12. No inflammable, explosive or dangerous fluids or substances shall be used or kept by Tenant in the Premises, Building or about the Property, except for those substances as are typically found in similar premises
used for general office purposes and are being used by Tenant in a safe manner and in accordance with all applicable Laws. Tenant shall not, without Landlord’s prior written consent, use, store, install, spill, remove, release or dispose of,
within or about the Premises or any other portion of the Property, any asbestos-containing materials or any solid, liquid or gaseous material now or subsequently considered toxic or hazardous under the provisions of 42 U.S.C. Section 9601 et seq. or
any other applicable environmental Law which may now or later be in effect, Tenant shall comply with all Laws pertaining to and governing the use of these materials by Tenant and shall remain solely liable for the costs of abatement and removal.

  
 13. Tenant shall not use or occupy the Premises in any manner
or for any purpose which might injure the reputation or impair the present or future value of the Premises or the Building. Tenant shall not use, or permit any part of the Premises to be used for lodging, sleeping or for any illegal purpose.

  

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 14. Tenant shall not take any action which would violate Landlord’s labor contracts or which would
cause a work stoppage, picketing, labor disruption or dispute or interfere with Landlord’s or any other tenant’s or occupant’s business or with the rights and privileges of any person lawfully in the Building (“Labor
Disruption”). Tenant shall take the actions necessary to resolve the Labor Disruption, and shall have pickets removed and, at the request of Landlord, immediately terminate any work in the Premises that gave rise to the Labor Disruption,
until Landlord gives its written consent for the work to resume. Tenant shall have no claim for damages against Landlord or any of the Landlord Related Pates nor shall the Commencement Date of the Term be extended as a result of the above actions.

  
 15. Tenant shall not install, operate or maintain in the
Premises or in any other area of the Building, electrical equipment that would overload the electrical system beyond its capacity for proper, efficient and safe operation as determined solely by Landlord. Tenant shall not furnish cooling or heating
to the Premises, including, without limitation, the use of electric or gas heating devices, without Landlord’s prior written consent. Tenant shall not use more than its proportionate share of telephone lines and other telecommunication
facilities available to service the Building. 
  
 16. Tenant shall
not operate or permit to the operated n coin or token operated vending machine or similar device (including, without limitation, telephones, lockers, toilets, scales, amusement devices and machines for sale of beverages, foods, candy, cigarettes and
other goods), except for machines for the exclusive use of Tenant’s employees and invitees. 
  
 17. Bicycles and other vehicles are not permitted inside the Building or on the walkways outside the Building, except in areas designated by Landlord.

  
 18. Landlord may from time to time adopt systems and
procedures for the security and safety of the Building and Property, its occupants, entry, use and contents. Tenant, its agents, employees, contractors, guests and invitees shall comply with Landlord’s systems and procedures. 
  
 19. Landlord shall have the right to prohibit the use of the name of the
Building or any other publicity by Tenant that in Landlord’s sole opinion may impair the reputation of the Building or its desirability. Upon written notice from Landlord, Tenant shall refrain from and discontinue such publicity immediately.

  
 20. Neither Tenant nor its agents, employees, contractors,
guests or invitees shall smoke or permit smoking in the Common Areas, unless a portion of the Common Areas have been declared a designated smoking area by Landlord, nor shall the above parties allow smoke from the Premises to emanate into the Common
Areas or any other part of the Building. Landlord shall have the right to designate the Building (including the Premises) as a non-smoking building. 
  
 21. Landlord shall have the right to designate and approve standard window coverings for the Premises and to establish rules to assure that the Building
presents a uniform exterior appearance. Tenant shall ensure, to the extent reasonably practicable, that window coverings are closed on windows in the Premises while they are exposed to the direct rays of the sun. 
  

 34 

 22. Deliveries to and from the Premises shall be made only at the times in the areas and through the
entrances and exits reasonably designated by Landlord. Tenant shall not make deliveries to or from the Premises in a manner that might interfere with the use by any other tenant of its premises or of the Common Areas, any pedestrian use, or any use
which is inconsistent with good business practice. 
  
 23. The
work of cleaning personnel shall not be hindered by Tenant after 5:30 p.m., and cleaning work may be done at any time when the offices are vacant. Windows, doors and fixtures may be cleaned at any time. Tenant shall provide adequate waste and
rubbish receptacles to prevent unreasonable hardship to the cleaning service. 
  

 35 

 EXHIBIT F 
 ADDITIONAL PROVISIONS 
  
 This Exhibit is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL TECHNOLOGIES, INC,, a Delaware
corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  

	1.	RENEWAL OPTION. 

  

	 	A.	Grant of Option Conditions. Tenant shall have the right to extend the Term (the “Renewal Option”) for one additional period of 5 years commencing on the day
following the Termination Date of the initial Term and ending on the 5th anniversary of the Termination Date (the “Renewal Term”), if: 

  

	 	1.	Landlord receives notice of exercise (“Initial Renewal Notice”) not less than 9 full calendar months prior to the expiration of the initial Term and not more than
12 full calendar months prior to the expiration of the initial Term; and 

  

	 	2.	Tenant is not in default under the Lease beyond any applicable cure periods at the time that Tenant delivers its Initial Renewal Notice or at the time Tenant delivers its Binding
Notice (as defined below); and 

  

	 	3.	No part of the Premises is sublet (other than pursuant to a Permitted Transfer, as defined in Section 11 of the Lease) at the time that Tenant delivers its Initial Renewal Notice or
at the time Tenant delivers its Binding Notice; and 

  

	 	4.	The Lease has not been assigned (other than pursuant to a Permitted Transfer, as defined in Section 11 of the Lease) prior to the date that Tenant delivers its Initial Renewal
Notice or prior to the date Tenant delivers its Binding Notice. 

  

	 	B.	Terms Applicable to Premises During Renewal Term. 

  

	 	1.	The initial Base Rent rate per rentable square foot for the Premises during the Renewal Term shall equal the Prevailing Market (hereinafter defined) rate per rentable square foot
for the Premises. Base Rent during the Renewal Term shall increase, if at all, in accordance with the increases assumed in the determination of Prevailing Market rate. Base Rent attributable to the Premises shall be payable in monthly installments
in accordance with the terms and conditions of Section 4 of the Lease. 

  

	 	2.	Tenant shall pay Additional Rent (i.e., Taxes and Expenses) for the Premises during the Renewal Term in accordance with Section 4 of the Lease, and the manner and method in which
Tenant reimburses Landlord 

  

	 	    	for Tenant’s share of Taxes and Expenses and the Base Year, if any, applicable to such matter, shall be some of the factors considered in determining the Prevailing Market rate
for the Renewal Term. 

  
 C. Procedure for
Determining Prevailing Market. Within 30 days after receipt of Tenant’s Initial Renewal Notice, Landlord shall advise Tenant of the applicable Base Rent rate for the Premises for the Renewal Term. Tenant, within 15 days after the date on
which Landlord advises Tenant of the applicable Base Rent rate for the Renewal Term, shall either (i) give Landlord final binding written notice (“Binding Notice”) of Tenant’s exercise of its Renewal Option, or (ii) if Tenant
disagrees with Landlord’s determination, provide Landlord with written notice of rejection (the “Rejection Notice”). If Tenant fails to provide Landlord with either a Binding Notice or Rejection Notice within such 15 day
period, Tenant’s Renewal Option shall be null and void and of no further force and effect. If Tenant provides Landlord with a Binding Notice, Landlord and Tenant shall enter into the Renewal Amendment (as defined below) upon the terms and
conditions set forth herein. If Tenant provides Landlord with a Rejection Notice, Landlord and Tenant shall work together in good faith to agree upon the Prevailing Market rate for the Premises during the Renewal Term. When Landlord and Tenant have
agreed upon the Prevailing Market rate for the Premises, such agreement shall be reflected in a written agreement between Landlord and Tenant, whether in a letter or otherwise, and Landlord and Tenant shall enter into the Renewal Amendment in
accordance with the terms and conditions hereof. Notwithstanding the foregoing, if Landlord and Tenant 8F8 unable t0 agree upon the Prevailing Market rate for the Premises within 30 days after the date Tenant provides Landlord with the Rejection
Notice, Tenant’s Renewal Option shall be deemed to be null and void and of no force and effect. 
  
 D. Renewal Amendment. If Tenant is entitled to and properly exercises its Renewal Option, Landlord shall prepare an amendment (the “Renewal
Amendment”) to reflect changes in the Base Rent, Term, Termination Date and other appropriate terms. The Renewal Amendment shall be sent to Tenant within a reasonable time after Landlord’s receipt of the Binding Notice or other written
agreement by Landlord and Tenant regarding the Prevailing Market rate, and Tenant shall execute and return the Renewal Amendment to Landlord within 15 days after Tenant’s receipt of same, but, upon final determination of the Prevailing Market
rate applicable during the Renewal Term as described herein, an otherwise valid exercise of the Renewal Option shall be fully effective whether or not the Renewal Amendment is executed. 
  
 E. Definition of Prevailing Market. For purposes of this Renewal Option, “Prevailing Market” shall
mean the arms length fair market annual rental rate per rentable square foot under renewal leases and amendments entered into on or about the date on which the Prevailing Market is being determined hereunder for space comparable to the Premises in
the Building and office buildings comparable to the Building in the Emeryville, California area. The determination of Prevailing Market shall take into account any material economic differences between the terms of this Lease and any comparison
lease or amendment, such as rent abatements, construction costs and other concessions and the manner, if any, in which the landlord under any such lease is reimbursed for operating expenses and taxes. The determination of Prevailing Market shall
also take into consideration any reasonably anticipated changes in the Prevailing Market rate from the time such Prevailing Market rate is being determined and the time such Prevailing Market rate will become effective under this Lease. 

 

 37 

 F. Subordination. Notwithstanding anything herein to the contrary, Tenant’s Renewal Option is
subject and subordinate to the expansion rights (whether such rights an designated as a right of first offer, right of first refusal, expansion option or otherwise) of any tenant of the Building existing on the date hereof. 
  

	2.	RIGHT OF FIRST OFFER. 

  
 A. Grant of Option: Conditions. Tenant shall have the one time right of first offer (the “Right of First Offer”)with respect to
the 2,596 rentable square feet on the 8th floor of the Building as shown on the demising plan attached hereto as Exhibit F-1 (the “Offering Space”). Tenant’s Right of First Offer shall be exercised as follows: at any
time after Landlord has determined that the existing tenant in the Offering Space will not extend or renew the term of its lease for the Offering Space (but prior to leasing such Offering Space to a party other than the existing tenant), Landlord
shall advise Tenant (the “Advice”) of the terms under which Landlord is prepared to lease the Offering Space to Tenant for the remainder of the Term, which terms shall reflect the Prevailing Market (hereinafter defined) rate for
such Offering Space as reasonably determined by Landlord, Tenant may lease such Offering Space in its entirety only, under such terms, by delivering written notice of exercise to Landlord (the “Notice of Exercise”) within 5 days
after the date of the Advice, except that Tenant shall have no such Right of First Offer and Landlord need not provide Tenant with an Advice, if: 
  

	 	1.	Tenant is in default under the Lease beyond any applicable cure periods at the time that Landlord would otherwise deliver the Advice; or 

  

	 	2.	the Premises, or any portion thereof, is sublet (other than pursuant to a Permitted Transfer, as defined in Section 11 of the Lease) at the time Landlord would otherwise deliver the
Advice; or 

  

	 	3.	the Lease has been assigned (other than pursuant to a Permitted Transfer, as defined in Section 11 of the Lease) prior to the date Landlord would otherwise deliver the Advice; or

  

	 	4.	Tenant is not occupying the Premises on the date Landlord would otherwise deliver the Advice; or 

  

	 	5.	the Offering Space is not intended for the exclusive use of Tenant during the Term; or 

  

	 	6.	the existing tenant in the Offering Space is interested in extending or renewing its lease for the Offering Space or entering into a new lease for such Offering Space.

  

	 	B.	Terms for Offering Space. 

  

	 	1.	The term for the Offering Space shall commence upon the commencement date stated in the Advice and thereupon such Offering Space shall be considered a part of the Premises, provided
that all of the terms stated in the Advice shall govern Tenant’s leasing of the Offering Space and only to the extent that they do not conflict with the Advice, the terms and conditions of this Lease shall apply to the Offering Space.

  

 38 

	 	2.	Tenant shall pay Base Rent and Additional Rent for the Offering Space in accordance with the terms and conditions of the Advice, which terms and conditions shall reflect the
Prevailing Market rate for the Offering Space as determined in Landlord’s reasonable judgment. 

  

	 	3.	The Offering Space (including improvements and personality, if any) shall be accepted by Tenant in its condition and as-built configuration existing on the earlier of the date
Tenant takes possession of the Offering Space or as of the date the term for such Offering Space commences, unless the Advice specifies any work to be performed by Landlord in the Offering Space, in which case Landlord shall perform such work in the
Offering Space. If Landlord is delayed delivering possession of the Offering Space due to the holdover or unlawful possession of such space by any party, Landlord shall use reasonable efforts to obtain possession of the space, and the commencement
of the term for the Offering Space shall be postponed until the date Landlord delivers possession of the Offering Space to Tenant free from occupancy by any party. 

  
 C. Termination of Right of First Offer. The rights of Tenant hereunder with respect to the Offering Space shall
terminate on the earlier to occur of: (i) August 2, 2009; (ii) Tenant’s failure to exercise its Right of First Offer within the 5-day period provided in Section A above; and (iii) the date Landlord would have provided Tenant an Advice if Tenant
had not been in violation of one or more of the conditions set forth in Section A above. In addition, if Landlord provides Tenant with an Advice for any portion of the Offering Space that contains expansion rights (whether such rights are described
as an expansion option, right of first refusal, right of first offer or otherwise) with respect to any other portion of the Offering space (such other portion of the Offering Space subject to such expansion rights is referred to herein as (the
“Encumbered Offering Space”) and Tenant does not exercise its Right of First Offer to lease the Offering Space described in the Advice, Tenant’s Right of First Offer with respect to the Encumbered Offering Space shall be
subject and subordinate to all such expansion rights contained in the Advice. 
  
 D. Offering Amendment. If Tenant exercises its Right of First Offer, Landlord shall prepare an amendment (the “Offering Amendment”) adding the Offering space to the Premises on the terms set
forth in the Advice and reflecting the changes in the Base Rent, Rentable Square Footage of the Premises, Tenant’s Pro Rata Share and other appropriate terms. A copy of the Offering Amendment shall be sent to Tenant within a reasonable time
after Landlord’s receipt of the Notice of Exercise executed by Tenant, and Tenant shall execute and return the Offering Amendment to Landlord within 15 days thereafter, but an otherwise valid exercise of the Right of First Offer shall be fully
effective whether or not the Offering Amendment is executed. 
  
 E. Definition of Prevailing Market. For purposes of this Right of First Offer provision, “Prevailing Market” shall mean the annual rental rate per square foot for space comparable to the Offering Space in the
Building and office buildings comparable to the 
  

 39 

 Building in the Emeryville, California area under leases and renewal and expansion amendments being entered into at or
about the time that Prevailing Market is being determined, giving appropriate consideration to tenant concessions, brokerage commissions, tenant improvement allowances, existing improvements in the space in question, and the method of allocating
operating expenses and taxes. Notwithstanding the foregoing, space leased under any of the following circumstances shall not be considered to be comparable for purposes hereof: (i) the lease term is for less than the lease term of the Offering
Space, (ii) the space is encumbered by the option rights of another tenant, or (iii) the space has a lack of windows and/or an awkward or unusual shape or configuration. The foregoing is not intended to be an exclusive list of space that will not be
considered to be comparable. 
  
 F. Subordination.
Notwithstanding anything herein to the contrary, Tenant’s Right of First Offer is subject and subordinate to the expansion rights (whether such rights are designated as a right of first offer, right of first refusal, expansion option or
otherwise) of any tenant of the Building existing on the date hereof. 
  

 40 

 EXHIBIT F-1 
 OFFERING SPACE 
  
 This
Exhibit (the “Offering Space”) is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL
TECHNOLOGIES, INC., a Delaware corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  
 [PROPERTY MAP] 
  
  

 EXHIBIT G 
 PARKING AGREEMENT 
  
 This
Exhibit (the “Parking Agreement”) is attached to and made a part of the Lease by and between CA-EMERYVILLE PROPERTIES LIMITED PARTNERSHIP, a Delaware limited partnership (“Landlord”) and NEUROBIOLOGICAL
TECHNOLOGIES, INC., a Delaware corporation (“Tenant”) for space in the Building located at 2000 Powell Street, Emeryville, California. 
  

	1.	During the initial Term, Tenant agrees to lease from Landlord and Landlord agrees to lease to Tenant a total of 29 non-reserved parking spaces and 0 reserved parking spaces in the
parking facility servicing the Building (“Parking Facility”). During the initial Term, Tenant shall pay in advance, concurrent with Tenant’s payment of monthly Base Rent, the prevailing monthly charges established from time to
time for parking in the Parking Facility. Such charges shall be payable to Landlord or such other entity as designated by Landlord, and shall be sent to the address Landlord designates from time to time. The initial charge for such parking spaces is
$60.00 per non-reserved parking pass, per month, and $0 per reserved parking pass, per month. Except as otherwise set forth herein below, no deductions from the monthly charge shall be made for days on which the Parking Facility is not used by
Tenant. Tenant may, from time to time request additional parking spaces, and if Landlord shall provide the same, such parking spaces shall be provided and used on a month-to-month basis, and otherwise on the following terms and provisions, and at
such prevailing monthly parking charges as shall be established from time to time. 

  

	2.	Tenant shall at all times comply with all applicable ordinances, rules, regulations, codes, laws, statutes and requirements of all federal, state, county and municipal governmental
bodies or their subdivisions respecting the use of the Parking Facility. Landlord reserves the right to adopt, modify and enforce reasonable rules (“Rules”) governing the use of the Parking Facility from time to time including any
key-card, sticker or other identification or entrance system and hours of operation. Landlord may refuse to permit any person who violates such Rules to park in the Parking Facility, and any violation of the Rules shall subject the car to removal
from the Parking Facility. Tenant shall comply with and cause its employees to comply with all the Rules as well as all reasonable additions and amendments thereto. 

  

	3.	Unless specified to the contrary above, the parking spaces hereunder shall be provided on a non-designated “first-come, first-served” basis. Subject to Tenant’s
rights to the reserved spaces set forth above, if any, Landlord reserves the right to assign other specific parking spaces, and to reserve other parking spaces for visitors, small cars, handicapped persons and for other tenants, guests of tenants or
other parties, which assignment and reservation or spaces may be relocated as determined by Landlord from time to time, and Tenant and persons designated by Tenant hereunder shall not park in any such location designated for such assigned or
reserved parking spaces. Tenant acknowledges that the Parking Facility may be closed entirely or in part in order to make repairs or perform maintenance services, or to alter, modify, re-stripe or renovate the Parking Facility, or if required by
casualty, strike, condemnation, act of God, governmental law or requirement or other reason beyond the operator’s reasonable control; and in such events, Landlord shall refund any prepaid parking fee hereunder, prorated on a per diem basis.

  

	4.	Tenant shall not store or permit its employees to store any automobiles in the Parking Facility without the prior written consent of the operator. Except for emergency repairs,
Tenant and its employees shall not perform any work on any automobiles while located in the Parking Facility, or on the Property. If it is necessary for Tenant or its employees to leave an automobile in the Parking Facility overnight, Tenant shall
provide the operator with prior notice thereof designating the license plate number and model of such automobile. 

  

	5.	LANDLORD SHALL NOT BE LIABLE FOR ANY LOSS, INJURY OR DAMAGE TO PERSONS USING THE PARKING FACILITY OR AUTOMOBILES OR OTHER PROPERTY THEREIN, IT BEING AGREED THAT, TO THE FULLEST
EXTENT PERMITTED BY LAW, THE USE OF THE SPACES SHALL BE AT THE SOLE RISK OF TENANT AND ITS EMPLOYEES. WITHOUT LIMITING THE FOREGOING, TENANT HEREBY VOLUNTARILY RELEASES, DISCHARGES, WAIVES AND RELINQUISHES ANY AND ALL ACTIONS OR CAUSES OF ACTION FOR
PERSONAL INJURY OR PROPERTY DAMAGE OCCURRING TO TENANT ARISING AS A RESULT OF PARKING IN THE PARKING FACILITY, OR ANY ACTIVITIES INCIDENTAL THERETO, WHEREVER OR HOWEVER THE SAME MAY OCCUR, AND FURTHER AGREES THAT TENANT WILL NOT PROSECUTE ANY CLAIM
FOR PERSONAL INJURY OR PROPERTY DAMAGE AGAINST LANDLORD OR ANY OF THE LANDLORD RELATED EVENTS, THEN LOOK FIRST TO ITS INSURANCE CARRIER AND TO REQUIRE THAT TENANT’S EMPLOYEES LOOK FIRST TO THEIR RESPECTIVE INSURANCE CARRIERS FOR PAYMENT OF ANY
LOSSES SUSTAINED IN CONNECTION WITH ANY USE OF THE PARKING FACILITY. TENANT HEREBY WAIVES ON BEHALF OF ITS INSURANCE CARRIERS ALL RIGHTS OF SUBROGATION AGAINST LANDLORD OR LANDLORD RELATED PARTIES. Notwithstanding the foregoing, but except as
provided in Section 15 of the Lease (Subrogation) and Section 20 of the Lease (Limitation of Liability) to the contrary, Tenant shall not be required to waive any claims against Landlord (other than for loss or damage to Tenant’s business)
where such loss or damage is due to the negligence or willful misconduct of Landlord or any Landlord Related Parties. 

  

	6.	Tenant shall not assign its rights under this Parking Agreement or sublease any of the parking spaces without the consent of Landlord. Landlord shall have the right to terminate
this Parking Agreement with respect to any parking spaces that Tenant desires to sublet or assign its rights thereto. 

  

	7.	Landlord hereby reserves the right to enter into a management agreement or lease with another entity for the operation of the Parking Facility (“Operator”). In such
event, Tenant, upon request of Landlord, shall enter into a parking agreement upon substantially the same terms hereunder with the Operator and pay the Operator the monthly charge established hereunder, and Landlord shall have no liability for
claims arising through acts or omissions of the Operator. It is understood and agreed that the identity of the Operator may change from time to time during the Term. In connection therewith, any parking lease or agreement entered into between Tenant
and any Operator shall be freely assignable by such Operator or any successors thereto. 

  

 43

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