Document:

Exclusive License Amending Agreement dated July 1, 2010

 Exhibit 10.15 
 EXCLUSIVE LICENSE AMENDING AGREEMENT 
 This Amending Agreement made the 1st
day of July 2010 (the “Amending Agreement”), 
 BETWEEN: 

UNIVERSITY OF VICTORIA INNOVATION AND DEVELOPMENT CORPORATION, a corporation owned by the University of Victoria,
having its principal office at R-Hut, McKenzie Avenue, Victoria, British Columbia, Canada, V8W 3W2 
 (“IDC”);

 AND: 

THE JOHNS HOPKINS UNIVERSITY, a non-profit corporation duly incorporated under the laws of Maryland, having an
office at 3400 N. Charles Street, Baltimore, Maryland, 21218, United States of America 
 (“JHU”); 

AND: 
 PROTOX
THERAPEUTICS INC., a corporation having its principal office at 1210 — 885 West Georgia Street, Vancouver, British Columbia Canada, V6C 3E8 
 (the “Licensee”). 
 WHEREAS: 

 

	A.	 pursuant to the terms and conditions of an exclusive license agreement, effective as of October 16, 2009 (the “Original
License”), a copy of which is annexed hereto as Schedule 1, IDC and JHU, as licensors, did grant to the Licensee an exclusive license to use certain Technology for use in certain Licensed Applications; 

 

	B.	 the Licensee has represented to IDC and JHU that it is not in breach of any material term of the Original License; and 

 

	C.	 the Licensee has requested, and IDC and JHU in reliance on the foregoing representation have agreed, to amend certain provisions of the Original
License, subject to the terms and conditions which follow. 

  
 1. 

 THEREFORE, for good and valuable consideration now paid the Licensee to each of IDC
and JHU, the receipt and sufficiency of which is hereby acknowledged, it is agreed as follows: 
  

	Section I	Definitions 

  

	1.	 Unless expressly provided elsewhere, capitalized terms in this Amending Agreement will have the meanings given to them in the Original License.

  

	Section II	Amendment 

  

	2.	 Article 2.7 of the Original License is deleted and replaced with the following: 

 

	 	2.7	 In the event that the Licensee sublicenses its rights to the Patent Rights in whole or in part, the Licensee shall provide to the Licensor a copy of
each sublicense granted within 45 days of it being signed by all parties to the sublicense. As a condition of its validity and enforceability, each sublicense agreement shall: 

 

	 	(a)	 incorporate, by reference, the terms and conditions of this Agreement 

 

	 	(b)	 be consistent with the terms and conditions and limitations of this Agreement; 

 

	 	(c)	 prohibit Sublicensee’s further sublicense of the rights delivered hereunder except in accordance with Article 2.9;

  

	 	(d)	 name Licensor as an intended third party beneficiary of the obligations of Sublicensee without imposition of obligation or liability on the part of
Licensor or Inventors to the Sublicensee; 

  

	 	(e)	 specifically incorporate the following Articles into the body of the sublicense agreement, and cause the terms therein to have the same meaning in
relation to the Sublicensee as in this Agreement in relation to the Licensee: Representation by Licensor, Indemnification, Use of Name, and Product Liability. 

To the extent that any terms, conditions or limitations of any sublicense agreement are inconsistent with this Agreement,
those terms, conditions and limitations are null and void against the Licensor. 
  

	3.	 The following is added as a new Article 2.9 of the Original License: 

 

	 	2.9	 The Licensee may permit a Sublicensee to further sublicense the Patent Rights through multiple tiers of sublicensees, provided that the
sub-sublicense agreement for each such sublicense shall: 

  

	 	(a)	 incorporate, by reference, the terms and conditions of this Agreement; 

  
 2. 

	 	(b)	 be consistent with the terms and conditions and limitations of this Agreement; 

 

	 	(c)	 prohibit any party to whom the Patent Rights are sub-sublicensed from assigning its rights or obligations thereunder; 

 

	 	(d)	 prohibit any party to whom the Patent Rights are sub-sublicensed from further sublicensing the Patent Rights or entering into other agreements
purporting to sell, lease, or license the Patent Rights, except in accordance with this Article 2.9; 

  

	 	(e)	 specifically incorporate the following Articles into the body of the sub-sublicense agreement, and cause the terms therein to have the same meaning
in relation to the Sublicensee as in this Agreement in relation to the Licensee: Representation by Licensor, Indemnification, Use of Name, and Product Liability, 

and provided further that: 
  

	 	(f)	 the Licensee provides notice to the Licensor of any proposed sub-sublicense by a Sublicensee not less than fifteen (15) business days prior to
commencement of the same; 

  

	 	(g)	 the Licensor has not, within fifteen (15) days following receipt of notice in accordance with Article 2.9 (f) above, provided the Licensee
with written notice that the Licensor does not consent to such sub-sublicense; 

  

	 	(h)	 at the time of such sub-sublicense, the Sublicensee is not in breach of any obligation arising under the sublicense agreement to which it is a
party. 

 To the extent that any terms, conditions or limitations of any sub-sublicense
agreement are inconsistent with this Agreement, those terms, conditions and limitations are null and void against the Licensor. 
  

	4.	 Article 3.4 of the Original License is deleted and replaced with the following: 

 

	 	3.4	 Payments for all running royalties are due on, and payable to the Licensor within sixty (60) days of, each respective Royalty and Other
Consideration Payment Due Date and will be calculated with respect to the Gross Sales in the three month period immediately preceding the applicable Royalty and Other Consideration Payment Due Date. 

  
 3. 

	5.	 Article 3.7 of the Original License is deleted and replaced with the following: 

 

	 	3.7	 Other Consideration does not include revenues or consideration associated with Gross Sales (as identified in Article 3.4). Similar to Article 3.5,
the payment of any Other Consideration will be due on, and payable to the Licensor within sixty (60) days of, each respective Royalty and Other Consideration Payment Due Date, and will be calculated with respect to the three month period
immediately preceding the applicable Royalty and Other Consideration Payment Due Date. 

  

	Section III	Continuation of Original License 

  

	6.	 The Original License will be deemed to be amended by this Amending Agreement with all necessary changes being made to incorporate and give effect to
the foregoing provisions from and after the date first written above. Except as amended herein, the Parties acknowledge and agree that the Original License will survive the execution and delivery of this Amending Agreement, will continue in full
force and effect, and will not merge in or with this Amending Agreement. 

  

	7.	 For clarity, but without limiting the generality of the foregoing, any reference to “Agreement” in the Original License as amended by this
Amending Agreement will be deemed to be a reference to the Original License as amended by this Amending Agreement. 

 IN WITNESS WHEREOF this Amending Agreement has been executed as of the day and year first above written. 
  

									
	UNIVERSITY OF VICTORIA	 		 		 	
	INNOVATION AND DEVELOPMENT CORPORATION	 		 	
					
	 Per:
	 		 		 		 	 Witness:

					
		 	 /s/ Brent Sternig
	 		 		 	 /s/ S. Keenlyside

		 	 Brent Sternig, President and CEO
	 		 		 	 (Print Name): S. Keenlyside

					
	 Date:
	 	 7/5/2010
	 		 		 	

  
 4. 

									
				
	THE JOHNS HOPKINS UNIVERSITY	 		 		 	
					
	 Per:
	 		 		 	 Witness:
	 	
					
		 	 /s/ Wesley D. Blakeslee
	 		 		 	 /s/ Jacqueline M. Flood

		 	 Wesley D. Blakeslee, Executive Director
	 		 		 	 (Print Name): Jacqueline M. Flood

		 	 John Hopkins Technology Transfer
	 		 		 	
					
	 Date:
	 	 8/10/2010
	 		 		 	
				
	PROTOX THERAPEUTICS INC.	 		 		 	
					
	 Per:
	 		 		 	 Witness:
	 	
					
		 	 /s/ Fahar Merchant
	 		 		 	 /s/ Shafique Eidai

		 	 Fahar Merchant, President and CEO
	 		 		 	 (Print Name): Shafique Eidai

					
	 Date:
	 	 6/28/2010
	 		 		 	

 SCHEDULE A 
 ORIGINAL LICENSE 

  
 6Office Service Agreement

 Exhibit 10.16 

 

			
	

	  	Office Service Agreement

  

									
	Agreement Date (dd/mm/yy):	 	February 22, 2011	 	Reference No.:	 	    8192-116029
			
	Business Centre Address:	 		 	Client Address (not a Regus Centre Address):
				
	HSBC Business Center	 		 	Company Name:	 	Protox Therapeutics Inc.
				
	Suite 1500 885 West Georgia Street	 		 	Contact Name:	 	John Parkinson
				
	Vancouver BC Canada V6C 3E8	 		 	Address:	 	1210 – 885 West Georgia Street
				
	Phone: 604 683 8144	 		 	Address:	 	Vancouver, BC Canada V6C 3E8
				
	Fax: 604 683 8125	 		 	Phone & Email:	 	604 688 0199 info@protoxtherapeutics.com

 Office Payment Detail (excluding local tax and excluding services) 

 

													
	Office Number	  	No. of People	  	Monthly Office Fee	 	  	Currency	 	 	 
					
	 1503
	  	8	  	 	6,125	  	  	 	CAD	  	 	
					
	 Total Per month
	  	8	  	 	6,125	  	  	 	CAD	  	 	
					
	 Initial Payment
	  	First Month’s Fee	  				  	 	—  	  	 	
					
		  	Service Retainer	  	 	2	  	  	 	12,250	  	 	
					
		  	Total Initial payment	  				  	 	12,250	  	 	
					
	 Monthly Payment
	  	Total monthly payment thereafter	  				  	 	6,125	  	 	
					
	 Length of Agreement
	  	Start Date	  	 	1 April 2011	  	  	 	End Date*	  	 	31 March 2013

  

	*	All agreements end on the last calendar day of the month. 

 Comments: 
 Regus agrees to waive the Monthly Office and Service fee (telecom, Internet,
kitchen amenities), for April 2011. Regus agrees to waive the office set up fee. The Client will have free services for the month of May 2011 to cover the cost of telecom/Internet activation. In addition to the Monthly Office Fee the client will pay
$1,080 monthly for 8 telecom service, 8 Internet connectivity, and 8 kitchen amenities. Regus will provide the client with $11,000 in free meeting room vouchers that can be used at any Regus location worldwide for half day and full day bookings.
Based on availability the Client may use the Galliano meeting room for one hour per day at no additional cost. If the Galliano Room is not available the hour may not be carried to subsequent days. 

We are RGN Management LP, (“Regus”). This Agreement incorporates our terms of business set out on attached Terms of Business which you confirm
you have read and understood. We both agree to comply with those terms and our obligations as set out in them. This agreement is binding from the agreement start date and may not be terminated once it is made, except in accordance with its terms.
Note that the Agreement does not come to an end automatically. See “Bringing your Agreement to an end” 
  

											
	Name (printed):	  	John Parkinson	  		  	Name (printed):	  	Kevin Foran	  	
						
	Title (printed):	  	CFO	  		  	Title (printed):	  	Area Sales Manager	  	
						
	Date:	  		  	February 22, 2011	  	Date:	  		  	February 22, 2011
				
	SIGNED on your behalf (Client)	  		  	SIGNED on your behalf	  	

  

									
	 /s/ John Parkinson
	 		 		 	 /s/ Kevin Foran
	 	

  

	 ̈	We would like to keep you informed of the latest product news, special offers and other marketing information from preferred partners. If you would like to receive this
information then select this box. 

  
 [Page 1 of 3]

 

 
 February 28, 2011 
 Addendum to Service Agreement 
 This addendum to the RGN Management
Limited Partnership Service Agreement (“your agreement”) dated February 22, 2011, between Protox Therapeutics Inc. (“the client’) and RGN Management Limited Partnership (“HSBC Business Center”), is entered into as
of this 28th day of February, 2011. 

WHEREAS the parties have entered into your agreement described above; 
 WHEREAS the parties agree to modify and add to certain terms of your agreement as described herein with effect from February 28, 2011 in the Regus HSBC business centre in Vancouver, BC; 

NOW WHEREFORE, the parties agree as follows: 
 Regus agrees that after April 1st 2012 the Client may downsize from suite 1503 with 90 days written notice. The financial obligation of the new premises rental rate and term shall be at least as much as the remainder for this Office
Service Agreement. Should the Client wish to end their tenancy after 15 months Regus will use every viable commercial option to re-lease the suite to another party. 
 All other terms and conditions of the client’s agreement shall remain the same. 
  

					
	Agreed to by:	 		 	
			
	John Parkinson	 		 	Kevin Foran
	Protox Therapeutics Inc.	 		 	Regus HSBC
			
	 /s/ John Parkinson
	 		 	 /s/ Kevin Foran

	(Signature)	 		 	(Signature)
			
	 Chief Financial Officer
	 		 	 ASM

	(Title)	 		 	(Title)
			
	 March 4 / 2011
	 		 	 March 4 / 2011

	(Date)	 		 	(Date)

  

					
		  	[Page 2 of 3]	  	

 TERMS AND CONDITIONS 

 

 1. This Agreement 
 1.1 Nature of the agreement: This agreement is the commercial equivalent of an agreement for accommodation(s) in a hotel. The whole of the Centre remains in Regus’ possession and control. THE CLIENT
ACCEPTS THAT THIS AGREEMENT CREATES NO TENANCY INTEREST, LEASEHOLD ESTATE OR OTHER REAL PROPERTY INTEREST IN THE CLIENT’S FAVOUR WITH RESPECT TO THE ACCOMMODATION(S). Regus is giving the Client the right to share with Regus the use of the
Centre on these terms and conditions, as supplemented by the House Rules, so that Regus can provide the service to the Client. This agreement is personal to the Client and cannot be transferred to anyone else. This agreement is composed of the front
page describing the accommodation(s), the present terms and conditions and the House Rules. 
 1.2 Comply with House Rules: The Client must
comply with any House Rules which Regus imposes generally on users of the Centre. The House Rules vary from country to country and from Centre to Centre and these can be requested locally. 
 1.3 Duration: This agreement lasts for period stated in it and then will be extended automatically for successive periods equal to the current term but no less than 3 months (unless legal renewal term
limits apply) until brought to an end by the Client or Regus. All periods shall run to the last day of the month in which they would otherwise expire. The fees on any renewal will be at the then prevailing market rate. 

1.4 Bringing the agreement to an end: Either Regus or the Client can terminate this agreement at the end date stated in it, or at the end of any
extension or renewal period, by giving at least three months written notice to the other. However, if this agreement, extension or renewal is for three months or less and either Regus or the Client wishes to terminate it, the notice period is two
months or (if shorter) one week less than the period stated in the agreement. 
 1.5 Ending this agreement immediately: To the maximum extent
permitted by applicable law, Regus may put an end to this agreement immediately by giving the Client notice and without need to follow any additional procedure if (a) the Client becomes insolvent, goes into liquidation or becomes unable to pay
its debts as they fall due, or (b) the Client is in breach of one of its obligations which cannot be put right or which Regus have given the Client notice to put right and which the Client has failed to put right within fourteen (14) days
of that notice, or (c) its conduct, or that of someone at the Centre with its permission or invitation, is incompatible with ordinary office use. 
 If Regus puts an end to this agreement for any of these reasons it does not put an end to any outstanding obligations, including additional services used and the monthly office fee for the remainder of
the period for which this agreement would have lasted if Regus had not ended it. 
 1.6 If the Centre is no longer available: In the event that
Regus is permanently unable to provide the service and accommodation(s) at the Centre stated in this agreement then this agreement will end and the Client will only have to pay monthly office fees up to the date it ends and for the additional
services the Client has used. Regus will try to find suitable alternative accommodation(s) for the Client at another Regus Centre. 
 1.7 When
this agreement ends the Client is to vacate the accommodation(s) immediately, leaving the accommodation(s) in the same condition as it was when the Client took it. Upon the Client’s departure or if the Client, at its option, chooses to relocate
to different rooms within the Centre, Regus will charge an Office Restoration Service fee to cover normal cleaning and testing and to return the accommodation(s) to its original state. The fee will differ by country and is listed in the House Rules.
Regus reserves the right to charge additional reasonable fees for any repairs needed above and beyond normal wear and tear. If the Client leaves any property in the Centre Regus may dispose of it at the Client’s cost in anyway Regus chooses
without owing the Client any responsibility for it or any proceeds of sale. When a Client vacates its accommodation(s) invariably Regus continues to receive the Client’s mail, faxes, telephone calls and visitors. In order to professionally
manage the redirection of the Client’s calls, mail, faxes and visitors Regus charges a one-time Business Continuity Service. This fee is located in the House Rules. 
 If the Client continues to use the accommodation(s) when this agreement has ended the Client is responsible for any loss, claim or liability Regus incurs as a result of the Client’s failure to vacate
on time. Regus may, at its discretion, permit the Client an extension subject to a surcharge on the monthly office fee. 
 1.8 Employees: While
this agreement is in force and for a period of six months after it ends, neither Regus nor the Client may knowingly solicit or offer employment to any of the other’s staff employed in the Centre. This obligation applies to any employee employed
at the Centre up to that employee’s termination of employment, and for three months thereafter. It is stipulated that the breaching party shall pay the non-breaching party the equivalent of one year’s salary for any employee concerned.
Nothing in this clause shall prevent either party from employing an individual who responds in good faith and independently to an advertisement which is made to the public at large. 
 1.9 Client Representation of Regus Employees: Throughout the duration of this agreement, Client agrees that neither Client, nor any of Client’s partners, members, officers or employees will
represent, or otherwise provide legal counsel to, any of Regus’ current or former employees in any dispute with, or legal proceeding against, Regus, or any of Regus’ affiliates, members, officers or employees. 

1.10 Notices: All formal notices must be in writing to the address first written above. 
 1.11 Confidentiality: The terms of this agreement are confidential. Neither Regus nor the Client must disclose them without the other’s consent unless required to do so by law or an official
authority. This obligation continues after this agreement ends. 
 1.12 Applicable law: This agreement is interpreted and enforced in accordance
with the laws of the place where the relevant Centre is located. Regus and the Client both accept the exclusive jurisdiction of the courts of such jurisdiction. If any provision of these terms and conditions is held void or unenforceable under the
applicable law, the other provisions shall remain in force. I the case of Japan all agreements will be interpreted and enforced by the Tokyo District Court. 
 1.13 Enforcing this agreement: The Client must pay any reasonable and proper costs including legal fees that Regus incurs in enforcing this agreement. 

2. Services and Obligations 
 2.1
Furnished office accommodation(s): Regus is to provide the number of services and furnished office accommodation(s) for which the Client has agreed to pay in the Centre stated in the agreement. This agreement lists the accommodation(s) Regus has
initially allocated to the Client’s use. The Client will have a non-exclusive right to the rooms allocated to it. Occasionally Regus may need to allocate different accommodation(s), but these accommodation(s) will be of reasonably equivalent
size and Regus will notify the Client with respect to such different accommodation(s) in advance. 
 2.2 Officer Services: Regus is to provide
during normal opening hours the services, if requested, described in the relevant service description (which is available on request). If Regus decides that a request for any particular service is excessive, it reserves the right to charge an
additional fee. 
 2.3 RegusNET: REGUS DOES NOT MAKE ANY REPRESENTATIONS AS TO THE SECURITY OF REGUS’ NETWORK (OR THE INTERNET) OR OF ANY
INFORMATION THAT THE CLIENT PLACES ON IT. The Client should adopt whatever security measures (such as encryption) it believes are appropriate to its circumstances. Regus cannot guarantee that a particular degree of availability will be attained in
connection with the Client’s use of Regus’ network (or the internet). The Client’s sole and exclusive remedy shall be the remedy of such failure by Regus within a reasonable time after written notice. 

3. Providing the Services 
 3.1
Access to the accommodation(s): Regus may need to enter the Client’s accommodation(s) and may do so at any time. However, unless there is an emergency or the Client has given notice to terminate, Regus will attempt to notify the Client verbally
or electronically in advance when Regus needs access to carry out testing, repair or works other than routine inspection, cleaning and maintenance. Regus will also endeavour to respect reasonable security procedures to protect the confidentiality of
the Client’s business. 
 3.2 Availability at the start of this agreement: If for any reason Regus cannot provide the accommodation(s)
stated in this agreement by the date when this agreement is due to start it has no liability to Client for any loss or damage but the Client may cancel this agreement without penalty. Regus will not charge the Client the monthly office fee for
accommodation(s) the Client cannot use until it becomes available. Regus may delay the start date of the agreement provided it provides to the Client alternative accommodation(s) that shall be at least of equivalent size to the accommodation(s)
stated in this agreement. 
 4. Accommodation(s) 
 4.1 The Client must not alter any part of its accommodation and must take good care of all parts of the centre, its equipment, fixtures, fittings and furnishings which the Client uses. The Client is
liable for any damage caused by it or those in the Centre with the Client’s permission or at the Client’s invitation whether express or implied, including but not limited to all employees, contractors, agents or other persons present in
the premises. 

 4.2 Office furniture and equipment: The Client must not install any cabling, IT or telecom connections
without Regus’ consent, which Regus may refuse at its absolute discretion. As a condition to Regus’ consent, the Client must permit Regus to oversee any installations (for example IT or electrical systems) and to verify that such
installations do not interfere with the use of the accommodation(s) by other Clients or Regus or any landlord of the building. 
 4.3 Insurance:
It is the Client’s responsibility to arrange insurance for its own property which it brings in to the Centre and for its own liability to its employees and to third parties. Regus strongly recommends that the Client put such insurance in place.

 5. Use 
 5.1 The
Client must only use the accommodation(s) for office purposes. Office use of a “retail” or “medical” nature, involving frequent visits by members of the public, is not permitted. 

5.2 The Client must not carry on a business that competes with Regus’ business of providing serviced office accommodation(s). 

5.3 The Client’s name and address: The Client may only carry on that business in its name or some other name that Regus previously agrees.

 5.4 Use of the Centre Address: The Client may use the Centre address as its business address. Any other uses are prohibited without
Regus’ prior written consent. 
 6. Compliance 
 6.1 Comply with the law: The Client must comply with all relevant laws and regulations in the conduct of its business. The Client must do nothing illegal in connection with its use of the Business Centre.
The Client must not do anything that may interfere with the use of the Centre by Regus or by others, cause any nuisance or annoyance, increase the insurance premiums Regus has to pay, o cause loss or damage to Regus (including damage to reputation)
or to the owner of any interest in the building which contains the Centre the Client is using. The Client acknowledges that (a) the terms of the foregoing sentence are a material inducement in Regus’ execution of this agreement and
(b) any violation by the Client of the foregoing sentence shall constitute a material default by the Client hereunder, entitling Regus to terminate this agreement, without further notice or procedure. 

6.2 The Client’s personal data may be transferred outside the European Union where Regus has a Centre for the purpose of providing the services
herein. Regus has adopted internal rules to ensure data protection in accordance with European regulations. 
 7. Regus’ Liability

 7.1 The extent of Regus’ liability: To the maximum extent permitted by applicable law, Regus is not liable to the Client in
respect of any loss or damage the Client suffers in connection with this agreement, with the services or with the Client’s accommodation(s) unless Regus has acted deliberately or negligently in causing that loss or damage. Regus is not liable
for any loss as a result of Regus’ failure to provide a service as a result of mechanical breakdown, strike, termination of Regus’ interest in the building containing the Centre or otherwise unless Regus does so deliberately or
negligently. In no event shall Regus be liable for any loss or damage until the Client provides Regus written notice and gives Regus a reasonable time to put it right. If Regus is liable for failing to provide the Client with any service under this
agreement then subject to the exclusion and limits set out immediately below Regus will pay any actual and reasonable expenses the Client has incurred in obtaining that service from an alternative source. If the Client believes Regus has failed to
deliver a service consistent with these terms and conditions the Client shall provide Regus written notice of such failure and give Regus a reasonable period to put it right. 
 7.2 EXCLUSION OF CONSEQUENTIAL LOSSES ETC.: REGUS WILL NOT IN ANY CIRCUMSTANCES HAVE ANY LIABILITY FOR LOSS OF BUSINESS, LOSS OF PROFITS, LOSS OF ANTICIPATED SAVINGS, LOSS OF OR DAMAGE TO DATA, THIRD
PARTY CLAIMS OR ANY CONSEQUENTIAL LOSS UNLESS REGUS OTHERWISE AGREES IN WRITING. REGUS STRONGLY ADVISES THE CLIENT TO INSURE AGAINST ALL SUCH POTENTIAL LOSS, DAMAGE, EXPENSE OR LIABILITY. 
 7.3 Financial limits to Regus’ liability: In all cases, Regus’ liability to the Client is subject to the following limits: 

 

	•	 	 Without limit for personal injury or death; 

  

	•	 	 Up to a maximum of £1 million / USD$2 million / €1.3 million (or local equivalent) for any one event or series of connected events
for damage to the Client’s personal property; 

  

	•	 	 Up to a maximum equal to 125% of the total fees paid between the date the Client moved into its accommodation(s) and the date on which the claim in
question arises or £50,000 / USD$100,000 / €66,000 (or local equivalent) whichever is the higher, in respect of any other loss or damage. 

 8. Fees 
 8.1 Taxes and duty charges: The Client agrees to pay promptly (i) all
sales, use, excise, consumption and any other taxes and license fees which it is required to pay to any governmental authority (and, at Regus’ request, will provide to Regus evidence of such payment) and (ii) any taxes paid by Regus to any
governmental authority that are attributable to the accommodation(s), including, without limitation, any gross receipts, rent and occupancy taxes, tangible personal property taxes, stamp tax or other documentary taxes and fees. 

8.2 Service Retainer/Deposit: The Client will be required to pay a service retainer/deposit equivalent to two months’ of the monthly office fee
(plus VAT/Tax where applicable) upon entering into this agreement unless a greater amount is specified on the front of this agreement. This will be held by Regus without generating interest as security for performance of all the Client’s
obligations under this agreement. The service retainer/ deposit or any balance after deducting fees, the Business Continuity and Office Restoration Service and other costs due to Regus, will be returned to the Client after the Client has settled its
account with Regus and funds have been cleared. 
 8.3 Regus may require the client to pay an increased retainer if outstanding fees exceed the
service retainer/ deposit held and/or the Client frequently fails to pay Regus when due. 
 8.4 The Client will be charged an office set up fee
per occupant. Fee amounts are located in the House Rules which can be requested at any time. 
 8.5 Payment: Regus is continually striving to
reduce its environmental impact and supports its clients in doing the same. Therefore Regus will send all invoices electronically (where allowed by law) and the Client will make payments via an automated method such as Direct Debt or Credit Card,
wherever local banking systems permit. 
 8.6 Late payment: If the Client does not pay fees when due, a fee will be charged on all overdue
balances. The fee will differ by country and is listed in the House Rules. If the Client disputes any part of an invoice the Client must pay the amount not in dispute by the due date or be subject to late fees. Regus also reserves the right to
withhold services (including for the avoidance of doubt, denying the Client access to accommodation(s)) while there are outstanding fees and/or interest or the Client is in breach of this agreement. 

8.7 Insufficient Funds: The Client will pay a fee for any returned cheque or any other declined payments due to insufficient funds. This fee will differ
by country and is listed in the House Rules. 
 8.8 Regus will increase the monthly office fee each and every anniversary of the start date of
this agreement by a percentage amount equal to the increase in the All items Retail Price Index, or such other broadly equivalent index which Regus substitutes provided that if the foregoing increase is not permitted by applicable law, then the
monthly office fee shall be increased as specified in the House Rules. This will only apply to agreements that have an original start and end date constituting more than a 12 month term. Renewals will be renewed as per clause1.3 above and only those
renewals with a start and end date constituting a term of over 12 months will have the same increase applied. 
 8.9 Standard services: The
monthly office fee and any recurring services requested by the Client are payable monthly in advance. Unless otherwise agreed in writing, these recurring services will be provided by Regus at the specified rates for the duration of this Agreement
(including any renewal). Specific due dates will differ by country and are listed in the House Rules. Where a daily rate applies, the charge for any such month will be 30 times the daily fee. For a period of less than a month the fee will be applied
on a daily basis. 
 8.10 Pay-as-you-use and Additional Variable Services: Fees for pay-as-you-use services, plus applicable taxes, in
accordance with Regus’ published rates which may change from time to time, are invoiced in arrears and payable the month following the calendar month in which the additional services were provided. Specific due dates will differ by country and
are listed in the House Rules. 
 8.11 Discounts, Promotions and Offers: If the Client benefitted from a special discount, promotion or offer,
Regus may discontinue that discount, promotion or offer without notice if the Client breaches these terms and conditions or becomes past due on two or more occasions.

 

  

					
		  	[Page 3 of 3]	  	

 

 
 ADDENDUM TO OFFICE SERVICE AGREEMENT 

This Addendum to Office Service Agreement (“Addendum”) is made and entered into effective as of May 11,
2012, by and between Sophiris Bio, Inc. / Protox Therapeutics, Inc. (“Client”) and REGUS MANAGEMENT GROUP, LLC (“Regus”). 
 Recitals 
  

	 	A.	WHEREAS, Client and Regus are parties to that certain Office Service Agreement (“Agreement”) dated February 22, 2011, pursuant to which
Regus provides certain services to Client; and 

  

	 	B.	WHEREAS, Client has requested certain amendments to its Agreement, and Regus, solely as an accommodation to Client, has agreed to such amendments under the following
terms and conditions. 

 NOW, THEREFORE, for and in consideration of the mutual covenants and conditions contained
herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties agree as follows: 
  

	1.	Amendment. The Agreement is hereby amended as follows: 

  

	 	a.	Effective July 1, 2012, the client will be downsized and relocated to office 1499 and adhere to payment Schedule A attached. 

 

	2.	Term. This Addendum shall automatically terminate concurrently with the termination of the Agreement. 

 

	3.	Control. Except as specifically modified or amended by the terms of this Addendum, the Agreement will remain in full force and effect. In the event of a
conflict between this Addendum and the Agreement or any attachment thereto, this Addendum shall control. 

  

	4.	Capitalized Terms. All capitalized terms not otherwise defined in this Addendum shall have their respective meanings set forth in the Agreement.

  

	5.	Counterparts. This Addendum may be executed in one or more counterparts, by original or by or through such other electronic form in which a party may
place or evidence its signature hereon, each of which will be deemed an original, but which collectively will constitute one and the same instrument. 

  

	6.	Interpretation. This Addendum and the Agreement together constitute the entire agreement between the parties with respect to the subject matter hereof and
thereof and supersede any and all prior and contemporaneous oral or written agreements between Parties with respect to the subject matter hereof and thereof. The parties each acknowledge and agree that they have carefully read this Addendum; that,
if they desire to do so, they have reviewed this Addendum with an attorney of their own choosing; that they fully understand that this Addendum is final and binding; and that they are voluntarily executing and delivering this Addendum to the other
party. The parties each acknowledge and agree that they participated equally in the preparation of this Addendum, and accordingly, if any provision of this Addendum requires judicial interpretation, the court interpreting such provision shall not
construe such provision or this Addendum against any party. If any provision of this Addendum shall be held to be illegal, invalid, or unenforceable, such provision will be enforced to the maximum extent permissible so as to effect the intent of the
parties, and the validity, legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

  
 1. 

  
 

 
 In Witness Whereof, the parties have executed this Addendum as of the date first above written. 

 

									
			
	CLIENT:	 		 	REGUS:
			
	Sophiris Bio, Inc.	 		 	REGUS MANAGEMENT GROUP, LLC
					
	By:	 	 /s/ Alexander Casdin
	 		 	By:	 	 /s/ Hegumi Mirazato

					
	Name:	 	 Alexander Casdin
	 		 	Name	 	 Hegumi Mirazato

					
	Title:	 	 CFO
	 		 	Title:	 	 Centre Manager

  
 2 

 Schedule A 

 

																					
	 	  	Office Fee	 	  	BoD	 	  	All other services	 	  	Dilap	  	ExitVO	  	Totals	 
	 May
	  	$	6,370.00	  	  	$	550.00	  	  	$	1,089.00	  	  		  		  	$	8,009.00	  
	 June
	  	 	6,370.00	  	  	 	550.00	  	  	 	1,089.00	  	  		  		  	$	8,009.00	  

  

																							
	Option 2 - Downsize to smaller office	  	 	 	  	Services	 	  	Dilap	 	  	Exit	 	  	 	 	  	 
							
	 July
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Aug
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Sept
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Oct
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Nov
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Dec
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Jan-13
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Feb
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744,00	  	  	
	 Mar
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Apr
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 May
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 Jun
	  	 	3,200.00	  	  	 	544.00	  	  				  				  	 	3,744.00	  	  	
	 July 4% anniversary increase
	  	 	3,328.00	  	  	 	544.00	  	  				  				  	 	3,872.00	  	  	
	 Aug
	  	 	3,328.00	  	  	 	544.00	  	  				  				  	 	3,872.00	  	  	
	 Sept
	  	 	3,328.00	  	  	 	544.00	  	  				  				  	 	3,872.00	  	  	
	 Oct
	  	 	3,328.00	  	  	 	544.00	  	  				  				  	 	3,872.00	  	  	
	 Nov
	  	 	3,328.00	  	  	 	544.00	  	  	 	3,540.00	  	  				  	 	7,412,00	  	  	Office1503
	 Dec – Remaining amount from initial agreement
	  	 	2,290.00	  	  	 	544.00	  	  	 	537.00	  	  	 	987.00	  	  	 	4,358.00	  	  	Office1499
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	
		  	 	57,330.00	  	  	 	9,792.00	  	  	 	4,077.00	  	  	 	987.00	  	  	 	72,186.00	  	  	plus tax

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00212-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00212-of-00352.parquet"}]]