Document:

Exhibit 4.2

 

EXECUTION VERSION

ABBVIE INC.

 

SUPPLEMENTAL INDENTURE NO. 6

 

€750,000,000 0.750% Senior Notes due
2027

€650,000,000 1.250% Senior Notes due
2031

 

THIS SUPPLEMENTAL INDENTURE
NO. 6, dated as of September 26, 2019 (the “Supplemental Indenture”),
among ABBVIE INC., a Delaware corporation (the “Company”), U.S. BANK
NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”),
ELAVON FINANCIAL SERVICES DAC, U.K. Branch, as paying agent (the “Paying Agent”),
and U.S. BANK NATIONAL ASSOCIATION, as transfer agent and registrar (the “Transfer Agent”
and/or “Security Registrar”).

 

RECITALS OF THE COMPANY:

 

WHEREAS, the Company
has heretofore executed and delivered to the Trustee an Indenture, dated as of November 8, 2012 (as it may be supplemented or amended
from time to time, the “Indenture”), providing for the issuance from
time to time of one or more series of Securities (as defined in the Indenture);

 

WHEREAS, the Company
has duly determined to appoint the Paying Agent as the paying agent and the Transfer Agent and Security Registrar as the transfer
agent and registrar, each under the Agency Agreement, dated as of the date hereof (“Agency
Agreement”), and the Paying Agent and the Transfer Agent and Security Registrar are willing to accept such appointment
with respect to the Notes;

 

WHEREAS, Article Nine
of the Indenture provides for various matters with respect to any series of Securities issued under the Indenture to be established
in an indenture supplemental to the Indenture;

 

WHEREAS, Section 9.1(7)
of the Indenture provides that the Company and the Trustee may enter into an indenture supplemental to the Indenture to establish
the form or terms of Securities of any series as permitted by Sections 2.1 and 3.1 of the Indenture; and

 

WHEREAS, all the conditions
and requirements necessary to make this Supplemental Indenture, when duly executed and delivered, a valid and binding agreement
in accordance with its terms and for the purposes herein expressed, have been performed and fulfilled.

 

NOW THEREFORE, THIS
SUPPLEMENTAL INDENTURE WITNESSETH:

 

For and in consideration
of the premises and the issuance of the series of Securities provided for herein, the Company and the Trustee mutually covenant
and agree for the equal and proportionate benefit of the respective Holders (as defined in the Indenture) of the Securities of
each such series as follows:

 

    

     

    

 

Article
I

 

RELATION TO INDENTURE; DEFINITIONS; RULES OF CONSTRUCTION

 

Section 1.1           
Relation to Indenture. This Supplemental Indenture constitutes an integral part of the Indenture.

 

Section 1.2            Relation to Agency Agreement. The terms of this Supplemental Indenture are subject to the terms of the Agency Agreement
which shall be deemed incorporated herein. In the event of an inconsistency between the terms of the Indenture, this Supplemental
Indenture and the Agency Agreement, the terms of the Agency Agreement shall prevail, except that the rights, benefits, protections,
indemnities and immunities of the Trustee shall be governed by the Indenture and this Supplemental Indenture.

 

Section 1.3           
Definitions. For all purposes of this Supplemental Indenture, the following terms shall have the respective meanings
set forth in this Section.

 

“2027
Notes” means the 0.750% Senior Notes due 2027.

 

“2031
Notes” means the 1.250% Senior Notes due 2031.

 

“Business
Day” means any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The
City of New York or London are authorized or required by law or executive order to close and (2) on which the Trans-European Automated
Real-Time Gross Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open.

 

“Clearstream,
Luxembourg” means Clearstream Banking S.A.

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, Luxembourg, which
initially shall be Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an
Independent Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German
government bond”), whose maturity is closest to the maturity of the notes, or if the Independent Investment Bank
in its discretion determines that such similar bond is not in issue, such other German government bond as the Independent Investment
Bank may, with the advice of three brokers of, and/or market makers in, German government bonds selected by the Company, determine
to be appropriate for determining the Comparable Government Bond Rate.

 

“Comparable
Government Bond Rate” means the yield to maturity, expressed as a percentage (rounded to three decimal places,
with 0.0005 being rounded upwards), on the third Business Day prior to the date fixed for redemption, of the Comparable Government
Bond on the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business
Day as determined by an Independent Investment Bank.

 

    2

     

    

 

“Corporate
Trust Office of the Paying Agent” means, initially, the office of Elavon Financial Services DAC, U.K. Branch located
at 125 Old Broad Street, London, EC2N 1AR, United Kingdom.

 

“Corporate
Trust Office of the Registrar and Transfer Agent” means, initially, the office of U.S. Bank National Association
located at 190 South LaSalle Street, 10th Floor Chicago, IL 60603.

 

“Definitive
Note” means a certificated Note that does not include the Global Notes Legend and in a customary form agreed by
the Company, the Trustee and the Paying Agent and security printed in accordance with any applicable legal and stock exchange requirements.

 

“euro”
or “€” means the currency of the member states of the European
Monetary Union that have adopted or that adopt the single currency in accordance with the treaty establishing the European Community,
as amended by the Treaty on European Union.

 

“Euroclear”
means Euroclear Bank SA/NV.

 

“Global
Notes Legend” means the legend set forth in Exhibits A1 through A3 to this Supplemental Indenture.

 

“Independent
Investment Bank” means an independent investment bank selected by the Company.

 

“Notes”
means the 2027 Notes and the 2031 Notes.

 

“Par Call
Date” means (i) with respect to the 2027 Notes, August 18, 2027 (three months prior to the maturity date of the 2027
Notes) and (ii) with respect to the 2031 Notes, August 18, 2031 (three months prior to the maturity date of the 2031 Notes).

 

“U.S.
Dollar” or “$” means the lawful currency of the United
States of America.

 

Section 1.4           Amendment
to Section 4.1 of the Indenture. Solely as it relates to the Notes, Section 4.1 of the Indenture shall be amended by replacing
subsection (1)(B) with the following:

 

(B)          all
Securities of such series not theretofore delivered to the Trustee for cancellation

 

(i)            have
become due and payable, or

 

(ii)           will
become due and payable at their Stated Maturity within one year, or

 

(iii)          if
redeemable at the Company’s option, are to be called for redemption within one year under arrangements satisfactory to the
Trustee for the giving of notice of redemption by the Trustee in the name, and at the expense, of the Company,

 

    3

     

    

 

and the Company, in the case of
(i), (ii) or (iii) above, has irrevocably deposited or caused to be deposited with the Trustee funds in an amount sufficient to
pay and discharge the entire indebtedness on such Securities of such series not theretofore delivered to the Trustee for cancellation,
for principal of, premium, if any, and interest on the Securities of such series to the date of such deposit (in the case of Securities
which have become due and payable), or to their Stated Maturity or the Redemption Date, as the case may be (provided that in connection
with any discharge relating to any redemption that requires the payment of a premium, the amount deposited shall be sufficient
for purposes of the Indenture to the extent that an amount is deposited with the Trustee equal to the premium calculated as of
the date of the notice of redemption, with any deficit as of the Redemption Date only required to be deposited with the Trustee
on or prior to the Redemption Date), together with irrevocable instructions from the Company directing the Trustee to apply such
funds to the payment thereof at Maturity or the Redemption Date, as the case may be;

 

Section 1.5            Amendment
to Section 5.1 of the Indenture.

 

(a)           Solely as it relates to the Notes, Section 5.1 of the Indenture shall be amended by replacing subsection (4) with
the following:

 

		(4)	default in the performance, or breach, of any covenant or warranty of the Company in this Indenture
(other than a covenant or warranty a default in whose performance or whose breach is elsewhere in this Section specifically
dealt with or which has expressly been included in this Indenture solely for the benefit of series of Securities other than that
series), and continuance of such default or breach for a period of 90 days after the giving of written notice to the Company by
the Trustee or to the Company and the Trustee by the Holders of at least 25% in principal amount of the Outstanding Securities
of that series a written notice specifying such default or breach and requiring it to be remedied and stating that such notice
is a “Notice of Default” hereunder (provided that such notice may not be given with respect to any action taken, and
reported publicly or to Holders of the Securities, more than two years prior to such notice);

 

(b)          Solely
as it relates to the Notes, Section 5.1 of the Indenture shall be amended by adding the following paragraph at the end of Section
5.1:

 

Any time period in this Indenture
to cure any actual or alleged default or Event of Default may be extended or stayed by a court of competent jurisdiction.

 

Section 1.6            Amendment
to Section 13.4 of the Indenture.

 

(a)           Solely
as it relates to the Notes, Section 13.4 of the Indenture shall be amended by replacing subsections (5) and (6) with the following:

 

    4

     

    

 

		(5)	In the case of an election under Section 13.2, the Company shall have delivered to the Trustee
an Opinion of Counsel stating that (x) the Company has received from, or there has been published by, the Internal Revenue Service
a ruling, or (y) since the date of this Indenture there has been a change in the applicable Federal income tax law, in either case
to the effect that, and based thereon such opinion shall confirm that, the beneficial owners of the Outstanding Securities of such
series will not recognize income, gain or loss for Federal income tax purposes as a result of such defeasance and will be subject
to Federal income tax on the same amounts, in the same manner and at the same times as would have been the case if such defeasance
had not occurred.

 

		(6)	In the case of an election under Section 13.3, the Company shall have delivered to the Trustee
an Opinion of Counsel to the effect that the beneficial owners of the Outstanding Securities of such series will not recognize
income, gain or loss for Federal income tax purposes as a result of such covenant defeasance and will be subject to Federal income
tax on the same amounts, in the same manner and at the same times as would have been the case if such covenant defeasance had not
occurred.

 

(b)          Solely
with respect to the Notes, the term “U.S. Government Obligations,”
defined in Section 13.4 of the Indenture, shall be deleted and replaced with the following: “euro
denominated securities that are direct obligations (or certificates representing an ownership interest in such obligations) of
a member state of the European Union as of the Issue Date (including any agency or instrumentality thereof) for the payment of
which the full faith and credit of such government is pledged; provided that such member state has a long-term government debt
rating of “A1” or higher by Moody’s or “A+” or higher
by S&P or the equivalent rating category of another internationally recognized rating agency.”

 

Section 1.7           
Rules of Construction. For all purposes of this Supplemental Indenture:

 

(a)           capitalized
terms used herein without definition shall have the meanings specified in the Indenture;

 

(b)           all
references herein to Articles and Sections, unless otherwise specified, refer to the corresponding Articles and Sections of this
Supplemental Indenture;

 

(c)           the
terms “herein,” “hereof,”
“hereunder” and other words of similar import refer to this Supplemental
Indenture; and

 

(d)           in the event of a conflict with the definition of terms in the Indenture, the definitions in this Supplemental Indenture
shall control.

 

Section 1.8           References.
References to the Security Register in the Indenture will be deemed to refer to the register of Holders of the Notes as prescribed
by this Supplemental Indenture, and the provisions of the Notes and references to the Security Registrar in the Indenture will
be deemed to refer to the Registrar as defined in the Agency Agreement and the Notes.

 

    5

     

    

 

Article
II 

 

THE SECURITIES

 

Section 2.1           
Title of the Notes. There shall be (i) a series of Securities designated the 0.750% Senior Notes due 2027 and (ii)
a series of Securities designated the 1.250% Senior Notes due 2031.

 

Section 2.2           
Initial Principal Amount. The 0.750% Senior Notes due 2027 will be initially issued in an aggregate principal amount
of €750,000,000 and the 1.250% Senior Notes due 2031 will be initially issued in an aggregate principal amount of €650,000,000.

 

Section 2.3           
Interest. Interest on each series of Notes will be payable in arrears on November 18 of each year, beginning on
November 18, 2019, to the persons in whose names the Notes are registered at the close of business on the date that is (i) in
the case of Notes represented by a Global Note, the clearing system business day (which, for these purposes, is a day on which
Euroclear and Clearstream, Luxembourg settle payments in euro) immediately prior to the relevant interest payment date and (ii)
in all other cases, 15 calendar days prior to the relevant interest payment date (whether or not a Business Day) (such day, the
“Record Date”). Interest on the Notes shall be determined on the basis
of the actual number of days in the period for which interest is being calculated, and including the last date on which interest
was paid or duly provided for on the Notes (or from September 26, 2019, if no interest has been paid on the Notes), but excluding
the next following interest payment date. This payment convention is referred to as ACTUAL/ACTUAL (ICMA) as defined in the rulebook
of the International Capital Market Association.

 

Section 2.4           
Issuance in Euro. Initial Holders will be required to pay for the Notes in euro, and all payments of principal of,
and premium, if any, and interest on, the Notes, including payments made upon redemption of the Notes, shall be payable in euro.
If the Company is unable to obtain euro in amounts sufficient to make a required payment under the Notes due to the imposition
of exchange controls or other circumstances beyond the Company’s control (including the dissolution of the European Monetary
Union) or if the euro is no longer being used by the then member states of the European Monetary Union that have adopted the euro
as their currency or for the settlement of transactions by public institutions or within the international banking community,
then all payments in respect of the Notes shall be made in U.S. Dollars until the euro is again available to the Company or so
used. In such circumstances, the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated
by the U.S. Federal Reserve Board as of the close of business on the second business day prior to the relevant payment date, or
in the event the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro
exchange rate available on or prior to the second business day prior to the relevant payment date as determined by the Company
in its sole discretion. Any payment in respect of the Notes so made in U.S. Dollar shall not constitute an Event of Default under
the Notes or the Indenture. Neither the Trustee nor the Paying Agent shall have any responsibility for any calculation or conversion
in connection with the foregoing.

 

    6

     

    

 

Section 2.5           
Form and Dating.

 

(a)           General.
The Notes shall initially be issued in the form of one or more global notes in fully registered, book-entry form (“Global
Securities”), duly executed by the Company and authenticated by the Trustee, which shall be deposited with the
Common Depositary and shall be registered in the name of USB Nominees (UK) Limited, as nominee of Elavon Financial Services DAC,
as common depositary for Euroclear and Clearstream, Luxembourg. The Notes shall be in substantially the forms of Exhibits A1,
A2, and A3, attached hereto. The Notes may have notations, legends or endorsements required by law, stock exchange rule or usage.
Each Note shall be dated the date of its authentication. The Notes shall be issued in fully registered form only in denominations
of €100,000 and integral multiples of €1,000 in excess thereof. The Notes of each series and any additional Notes of
such series subsequently issued under the Indenture will be treated as a single series or class for all purposes under the Indenture,
including, without limitation, waivers, amendments and redemptions, provided that if any such additional Notes are not fungible
with the existing Notes for Federal income tax purposes, such additional Notes will have a separate CUSIP number.

 

The terms and provisions
contained in the Notes shall constitute, and are hereby expressly made, a part of this Supplemental Indenture, and the Company
and the Trustee, by their execution and delivery of this Supplemental Indenture, expressly agree to such terms and provisions and
to be bound thereby. However, to the extent any provision of any Note conflicts with the express provisions of this Supplemental
Indenture, the provisions of this Supplemental Indenture shall govern and be controlling.

 

(b)           Book-Entry
Provisions. This Section 2.5(b) shall apply only to a Global Note deposited with the Common Depositary. The Company shall
execute and the Trustee shall, in accordance with this Section 2.5(b) and pursuant to an order of the Company, authenticate and
deliver initially one or more Global Notes that (a) shall be registered in the name of USB Nominees (UK) Limited, as nominee of
the Common Depositary for such Global Note or Global Notes and (b) shall be delivered by the Trustee to such Common Depositary.

 

(c)           Payment. The Company will make payments on the Notes in euro at the office of the Trustee (in the limited
circumstances specified in the Indenture), the Paying Agent or any paying agent the Company designates (which paying agent may
include the Company). At its option, the Company may make payments of interest by (i) check mailed to the address of the Person
entitled thereto as such address shall appear in the security register; or (ii) wire transfer as directed by the Holder of any
Note, in immediately available funds to an account maintained by the Common Depositary or its nominee with respect to a Global
Note, and to the Holder of any Note or its nominee with respect to a Definitive Note; provided further that in the case of a Definitive
Note (x) the Holder thereof shall have provided written wiring instructions to the Paying Agent on or before the related Record
Date and (y) if appropriate instructions for any such wire transfer are not received by the related Record Date, then such payment
shall be made by check mailed to the address of such Holder specified in the Security Register. The Company will make interest
payments to the Holder in whose name the Note is registered at the close of business on the Record Date for the interest payment.

 

    7

     

    

 

Payment of principal
in respect of the Notes and payment of accrued interest payable on redemption of the Notes (other than on an interest payment date)
will be made to the Persons shown in the Security Register at the close of business on the Record Date, subject to surrender (or
in the case of partial payment only, endorsement) of the relevant note, at the specified office of the Paying Agent. Payments of
interest due on any interest payment date will be made to the Persons shown in the Security Register at close of business on the
Record Date. Payments of all other amounts will be made as provided in the Indenture.

 

If the principal of
or any premium or interest on the Notes is payable on a day that is not a Payment Business Day, the payment will be made on the
following Payment Business Day without the accrual of any interest on that payment.

 

For these purposes
“Payment Business Day” means any day that is:

 

		a)	a day on which commercial banks and foreign exchange markets settle payments and are open for general
business (including dealing in foreign exchange and foreign currency deposits) in, in the case of Definitive Notes only, the relevant
place of presentation;

 

		b)	a day on which the TARGET 2 System is open, and

 

		c)	in the case of any payment in respect of a Global Note, a day on which Euroclear and/or Clearstream,
Luxembourg, as the case may be, settle(s) payments in euro.

 

For these purposes
“TARGET 2 System” means the Trans-European Automatic Real- Time Gross
Settlement Express Transfer (TARGET 2) System.

 

All payments of any
amounts paid to or the order of USB Nominees (UK) Limited as nominee for the Common Depositary for Euroclear and Clearstream, Luxembourg
shall be valid and, to the extent of the sums so paid, effectual to satisfy and discharge the liability of the Company for the
moneys payable on the Notes.

 

The Company has designated
the Paying Agent as its paying agent for payments on Notes. The Company may at any time designate additional paying agents or rescind
the designation of any paying agent or approve a change in the office through which any paying agent acts.

 

The Trustee or Paying
Agent, as applicable, will repay to the Company on the Company’s written request any funds they hold for payments on the
Notes that remain unclaimed for two years after the date upon which that payment has become due. After repayment to the Company,
Holders entitled to those funds must look only to it for payment.

 

(d)           Definitive
Notes. Except as provided in this Section 2.5, owners of a beneficial interest in the Global Notes will not have Notes registered
in their names, will not receive physical delivery of Definitive Notes and will not be considered the registered owners or “holders”
thereof under the Indenture for any purpose.

 

    8

     

    

 

Section 2.6            Transfer
and Exchange.

 

(a)          Transfer
and Exchange of Definitive Notes. When Definitive Notes are presented to the Security Registrar with a request:

 

(i)            to
register the transfer of such Definitive Notes; or

 

(ii)           to
exchange such Definitive Notes for an equal principal amount of Definitive Notes of other authorized denominations, the Security
Registrar shall register the transfer or make the exchange as requested if its reasonable requirements for such transaction are
met; provided, however, that the Definitive Notes surrendered for transfer or exchange:

 

(A)         shall
be duly endorsed or accompanied by a written instrument of transfer in form reasonably satisfactory to the Company and the Security
Registrar, duly executed by the Holder thereof or his attorney duly authorized in writing; and

 

(B)          are
accompanied by the following additional information and documents, as applicable:

 

(x)         if
such Definitive Notes are being delivered to the Security Registrar by a Holder for registration in the name of such Holder, without
transfer, a certification from such Holder to that effect (in the form set forth on the reverse side of the Note); or

 

(y)        if
such Definitive Notes are being transferred to the Company, a certification to that effect (in the form satisfactory to the Trustee).

 

(b)           Restrictions
on Transfer of a Definitive Note for a Beneficial Interest in a Global Note. A Definitive Note may not be exchanged for a
beneficial interest in a Global Note except upon satisfaction of the requirement set forth below. Upon receipt by the Trustee
of a Definitive Note, duly endorsed or accompanied by a written instrument of transfer in form reasonably satisfactory to the
Company and the Security Registrar, together with written instructions directing the Trustee to make an adjustment on its books
and records with respect to such Global Note to reflect an increase in the aggregate principal amount of the Notes represented
by the Global Note, such instructions to contain information regarding the Common Depositary account to be credited with such
increase, then the Trustee shall cancel such Definitive Note and cause the aggregate principal amount of Notes represented by
the Global Note to be increased by the aggregate principal amount of the Definitive Note to be exchanged and shall credit or cause
to be credited to the account of the Person specified in such instructions a beneficial interest in the Global Note equal to the
principal amount of the Definitive Note so canceled. If no Global Notes are then outstanding and the Global Note has not been
previously exchanged for certificated securities pursuant to this Section 2.6, the Company shall issue and the Trustee shall authenticate,
upon receipt of a Company Order, a new Global Note in the appropriate principal amount.

 

(c)           Exchange
of Global Notes for Definitive Notes. A Global Note shall be exchanged by the Company for Definitive Notes only if:

 

    9

     

    

 

(i)            an
Event of Default has occurred and is continuing; or

 

(ii)           either
Euroclear or Clearsteam, Luxembourg is closed for business for a continuous period of 14 days or more (other than by reason of
holiday, statutory or otherwise) or announces an intention permanently to cease business or does in fact do so and no alternative
clearing system satisfactory to the Trustee is available; or

 

(iii)          the
Company would suffer a disadvantage as a result of a change in laws or regulations (taxation or otherwise) or as a result of a
change in the practice of Euroclear and/or Clearstream, Luxembourg which would not be suffered were the Notes in definitive form
and a certificate to such effect signed by an authorized signatory of the Company is given to the Trustee.

 

In the case
of (i) or (ii) above, the Holder of a Global Note (acting on behalf of one or more of the accountholders) or the Trustee may give
notice to the Company and, in the case of (iii) above, the Company may give notice to the Trustee and the Holders of Notes, of
its intention to exchange a Global Note for Definitive Notes on or after the Exchange Date (as defined below).

 

On or after
the Exchange Date the Holder of the Global Note may, or in the case of (iii) above, shall surrender it to or to the order of the
Paying Agent. In exchange for the Global Note, the Company shall deliver, or procure the delivery of, an equal aggregate principal
amount of Definitive Notes, security printed in accordance with any applicable legal and stock exchange requirements. On exchange
of the Global Note, the Company will procure that it is cancelled and, if the Holder so requests, returned to the Holder together
with any relevant Definitive Notes.

 

For these
purposes, “Exchange Date” means a day specified in the notice requiring
exchange falling not less than 60 days after that on which the notice requiring exchange is given and being a day on which banks
are open for general business in London, the place in which the specified office of the Paying Agent is located and, except in
the case of exchange pursuant to (ii) above, in the place in which Euroclear and Clearstream, Luxembourg are located.

 

In all cases,
Definitive Notes delivered in exchange for any Global Note or beneficial interests in Global Notes will be registered in the names,
and issued in any approved denominations, requested by or on behalf of the Holder of the relevant Global Notes.

 

Neither the
Company nor the Trustee will be liable for any delay by the Holder of the relevant Global Notes in identifying the Holders of beneficial
interests in the Global Notes, and each such Person may conclusively rely on, and will be protected in relying on, instructions
from Euroclear or Clearstream, Luxembourg for all purposes (including with respect to the registration and delivery and the respective
principal amounts, of the Definitive Notes to be issued).

 

    10

     

    

 

(d)          Obligations
with Respect to Transfers and Exchanges of Notes.

 

(i)            To
permit registrations of transfers and exchanges, the Company shall execute and the Trustee shall authenticate Definitive Notes
and Global Notes at the Company’s request.

 

(ii)           No
service charge shall be made for any registration of transfer or exchange of the Notes, but the Company or the Security Registrar
may require payment of a sum sufficient to cover any transfer tax, assessments, or similar governmental charge payable in connection
therewith (other than any such transfer taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant
to Sections 9.6 or 11.7 of the Indenture).

 

(e)           Prior
to the due presentation for registration of transfer of any Note, the Company, the Trustee, the Paying Agent or the Security Registrar
may deem and treat the Person in whose name a Note is registered as the absolute owner of such Note for the purpose of receiving
payment of principal of and interest on such Note and for all other purposes whatsoever, whether or not such Note is overdue,
and none of the Company, the Trustee, the Paying Agent or the Security Registrar shall be affected by notice to the contrary.

 

(f)           The Company hereby appoints the Security Registrar as Security Registrar for the Notes. Neither the Company nor the
Security Registrar shall be required to register the transfer of or exchange Notes of any series (i) during a period beginning
at the opening of business 15 days before the day of the mailing of a notice of redemption of Notes of that series selected for
redemption under Section 11.3 of the Indenture and ending at the close of business on the day of such mailing, or (ii) so selected
for redemption in whole or in part, except the unredeemed portion of any Note being redeemed in part.

 

(g)          All
Notes issued upon any transfer or exchange pursuant to the terms of this Supplemental Indenture shall evidence the same Debt and
shall be entitled to the same benefits under the Indenture as the Notes surrendered upon such transfer or exchange.

 

(h)          No
Obligation of the Trustee.

 

(i)            The
Trustee shall have no responsibility or obligation to any beneficial owner of a Global Note, the Common Depositary or any other
Person with respect to the accuracy of the records of the Common Depositary or its nominee, with respect to any ownership interest
in the Notes or with respect to the delivery to any beneficial owner or other Person (other than the Common Depositary) of any
notice (including any notice of redemption or repurchase) or the payment of any amount, under or with respect to such Notes. All
notices and communications to be given to the Holders and all payments to be made to Holders under the Notes shall be given or
made only to the Holders (which shall be the Common Depositary or its nominee in the case of a Global Note). The rights of beneficial
owners in any Global Note shall be exercised only through the Common Depositary subject to the applicable rules and procedures
of the Common Depositary. The Trustee may rely and shall be fully protected in relying upon information furnished by the Common
Depositary with respect to any beneficial owners.

 

    11

     

    

 

(ii)           The
Trustee shall have no obligation or duty to monitor, determine or inquire as to compliance with any restrictions on transfer imposed
under this Supplemental Indenture or under applicable law with respect to any transfer of any interest in any Note (including
any transfers between or among beneficial owners in any Global Note) other than to require delivery of such certificates and other
documentation or evidence as are expressly required by, and to do so if and when expressly required by, the terms of this Supplemental
Indenture, and to examine the same to determine substantial compliance as to form with the express requirements hereof.

 

Article
III 

 

TRUSTEE AND PAYING AGENT

 

Section 3.1           
Appointments. The Paying Agent for the Notes shall initially be Elavon Financial Services DAC, U.K. Branch. The
Company hereby initially designates the Corporate Trust Office of the Paying Agent as the office to be maintained by it where
Notes may be presented for payment and where notices to or demands upon the Company in respect of the Notes or the Indenture may
be served. The Security Registrar and Transfer Agent for the Notes shall initially be U.S. Bank National Association and the Company
hereby initially designates the Corporate Trust Office of the Security Registrar and Transfer Agent as the office to be maintained
by it where Notes may be presented for registration of transfer or exchange. The Company reserves the right at any time to vary
or terminate the appointment of the Paying Agent or Security Registrar, to appoint additional or other paying agents or another
security registrar and to approve any change in the office through which any paying agent or security registrar acts. In furtherance
of such appointment, the Trustee is hereby authorized and directed to execute and deliver the Agency Agreement. The Trustee shall
not be liable for any act or omission of the Paying Agent, Security Registrar, Transfer Agent, Common Depositary, Euroclear or
Clearstream, Luxembourg. In considering the interests of Holders of the Notes while any relevant Global Notes are held on behalf
of Euroclear and Clearstream, Luxembourg, the Trustee may have regard to any information provided to it by such clearing systems
as to the identity (either individually or by category) of their accountholders and may consider such interests as if such accountholders
were Holders of the relevant Global Notes and interests therein.

 

Article
IV 

 

REDEMPTION

 

Section 4.1           
Optional Redemption.

 

(a)           At
any time prior to the Par Call Date applicable to a series of Notes, the Company may redeem some or all of the Notes of such series,
in each case at the Company’s option, at a redemption price equal to the greater of:

 

(i)            100%
of the principal amount of the Notes of that series to be redeemed; and

 

    12

     

    

 

(ii)           the sum of the present values of the remaining scheduled payments (through the Par Call Date with respect to such
Notes assuming for such purpose that such Notes matured on the applicable Par Call Date) of principal and interest on the Notes
to be redeemed (exclusive of interest accrued to the date of redemption) discounted to the date of redemption on an annual basis
(ACTUAL/ACTUAL (ICMA)) at the applicable Comparable Government Bond Rate (as defined herein) plus 25 basis points for the 2027
Notes and 30 basis points for the 2031 Notes.

 

In each case, the Company will
pay accrued and unpaid interest on the principal amount being redeemed to, but excluding, the date of redemption.

 

(b)           In
addition, at any time on or after the Par Call Date applicable to a series of Notes, the Company may redeem some or all of the
Notes of such series, in each case at the Company’s option, at a redemption price equal to 100% of the principal amount
of the Notes of such series to be redeemed, plus, in each case, accrued and unpaid interest on the principal amount being redeemed
to, but excluding, the date of redemption.

 

(c)           Notice
of redemption will be mailed at least 30 but not more than 60 days before the redemption date (i) in the case of Notes represented
by a Global Note, to and through Euroclear or Clearstream, Luxembourg for communication by them to the holders of interests in
the Notes, or (ii) in the case of Definitive Notes, to each Holder of the Notes to be redeemed at its registered address. The
notice of redemption for the Notes will state, among other things, the series and amount of Notes to be redeemed, the redemption
date, the redemption price and the place or places that payment will be made upon presentation and surrender of Notes to be redeemed.
Unless the Company defaults in the payment of the redemption price, interest will cease to accrue on any Notes that have been
called for redemption at the redemption date. If fewer than all of the Notes of a series are to be redeemed at any time (i) in
the case of Notes represented by a Global Note, the Notes will be selected in accordance with the rules of Euroclear and/or Clearstream,
Luxembourg (to be reflected in the records of Euroclear and Clearstream, Luxembourg as either a pool factor or a reduction in
nominal amount, at their discretion), or (ii) in the case of Definitive Notes, the Trustee will select, not more than 45 days
prior to the redemption date, the particular Notes or portions thereof for redemption from the outstanding Notes not previously
redeemed by random lot.

 

Section 4.2           
Redemption for Tax Reasons. If, as a result of any change in, or amendment to, the laws (or any regulations or rulings
promulgated under the laws) of the United States (or any taxing authority in the United States), or any change in, or amendment
to, an official position or judicial precedent regarding the application or interpretation of such laws, regulations or rulings,
which change or amendment is announced or becomes effective on or after the date of this prospectus supplement, the Company becomes
or, based upon a written opinion of independent counsel selected by it, will become obligated to pay additional amounts (as described
in Article V hereunder) with respect to a series of Notes, then the Company may at any time at its option redeem, in whole, but
not in part, the Notes of such series on not less than 30 nor more than 60 days’ prior notice, (i) in the case of Notes
represented by a Global Note, to and through Euroclear or Clearstream, Luxembourg for communication by them to the holders of
interests in the Notes to be so redeemed, or (ii) in the case of Definitive Notes, to each Holder of the Notes to be redeemed
at its registered address, at a redemption price equal to 100% of their principal amount plus accrued and unpaid interest to the
redemption date.

 

    13

     

    

 

Article
V 

 

PAYMENT OF ADDITIONAL AMOUNTS

 

Section 5.1           
General. The Company will, subject to the exceptions and limitations set forth below, pay as additional interest
on each series of the Notes such additional amounts (the “Additional Amounts”)
as are necessary in order that the net amount of the principal of, and premium, if any, and interest on such Notes received by
a beneficial owner who is not a U.S. person (as defined below), after withholding or deduction for any future tax, assessment
or other governmental charge imposed by the United States or a taxing authority in the United States, will not be less than the
amount provided in the Notes to be then due and payable; provided, however, that the foregoing obligation to pay Additional Amounts
shall not apply:

 

(a)           to
any tax, assessment or other governmental charge that would not have been imposed but for the Holder (or the beneficial owner
for whose benefit such Holder holds such Note), or a fiduciary, settlor, beneficiary, member or shareholder of the Holder if the
Holder is an estate, trust, partnership or corporation, or a Person holding a power over an estate or trust administered by a
fiduciary holder, being considered as:

 

(i)            being
or having been engaged in a trade or business in the United States or having or having had a permanent establishment in the United
States;

 

(ii)           having
a current or former connection with the United States (other than a connection arising solely as a result of the ownership of
the Notes, the receipt of any payment or the enforcement of any rights thereunder), including being or having been a citizen or
resident of the United States;

 

(iii)          being
or having been a personal holding company, a passive foreign investment company or a controlled foreign corporation for U.S. federal
income tax purposes or a corporation that has accumulated earnings to avoid U.S. federal income tax;

 

(iv)          being
or having been a “10-percent shareholder” of the Company within the meaning
of Section 871(h)(3) of the U.S. Internal Revenue Code of 1986, as amended (the “Code”),
or any successor provision; or

 

(v)           being
a bank receiving payments on an extension of credit made pursuant to a loan agreement entered into in the ordinary course of its
trade or business;

 

(b)           to
any Holder that is not the sole beneficial owner of the Notes, or a portion of the Notes, or that is a fiduciary, partnership
or limited liability company, but only to the extent that a beneficial owner with respect to the Holder, a beneficiary or settlor
with respect to the fiduciary, a beneficial owner or member of the partnership or limited liability company would not have been
entitled to the payment of an Additional Amount had the beneficiary, settlor, beneficial owner or member received directly its
beneficial or distributive share of the payment;

 

    14

     

    

 

(c)           to
any tax, assessment or other governmental charge that would not have been imposed but for the failure of the Holder or beneficial
owner or any other Person to comply with certification, identification or information reporting requirements concerning the nationality,
residence, identity or connection with the United States of the Holder or beneficial owner of the Notes, if compliance is required
by statute, by regulation of the United States or any taxing authority therein or by an applicable income tax treaty to which
the United States is a party as a precondition to exemption from such tax, assessment or other governmental charge;

 

(d)          to
any tax, assessment or other governmental charge that is imposed otherwise than by withholding by the Company or a paying agent
from the payment;

 

(e)           to
any tax, assessment or other governmental charge that would not have been imposed but for a change in law, regulation, or administrative
or judicial interpretation that becomes effective more than 15 days after the payment becomes due or is duly provided for, whichever
occurs later;

 

(f)           to
any estate, inheritance, gift, sales, excise, transfer, wealth, capital gains or personal property tax or similar tax, assessment
or other governmental charge;

 

(g)          to any tax, assessment or other governmental charge required to be withheld by any paying agent from any payment
of principal of or interest on any Note, if such payment can be made without such withholding by at least one other paying agent;

 

(h)          to
any tax, assessment or other governmental charge that would not have been imposed but for the presentation by the Holder of any
Note, where presentation is required, for payment on a date more than 30 days after the date on which payment became due and payable
or the date on which payment thereof is duly provided for, whichever occurs later;

 

(i)            to
any tax, assessment or other governmental charge that would not have been imposed or withheld but for the beneficial owner being
a bank (i) purchasing the Notes in the ordinary course of its lending business or (ii) that is neither (A) buying the Notes for
investment purposes only nor (B) buying the Notes for resale to a third-party that either is not a bank or holding the Notes for
investment purposes only;

 

(j)            to
any tax, assessment or other governmental charge imposed under Sections 1471 through 1474 of the Code (or any amended or successor
provisions), any current or future regulations or official interpretations thereof, any agreement entered into pursuant to Section
1471(b) of the Code, any intergovernmental agreement entered into in connection with the implementation of such sections of the
Code or any fiscal or regulatory legislation, rules or practices adopted pursuant to any such intergovernmental agreement; or

 

(k)           in
the case of any combination of items (a) through (j).

 

Section 5.2           No
Other Requirements. The Notes are subject in all cases to any tax, fiscal or other law or regulation or administrative or
judicial interpretation applicable to the Notes. Except as specifically provided under this Article V, the Company shall not be
required to make any payment for any tax, duty, assessment or governmental charge imposed by any government or a political subdivision
or taxing authority of or in any government or political subdivision.

 

    15

     

    

 

Section 5.3           Definition.
As used in this Article V, the term ‘‘United States’’ means the United States of America, the states of
the United States, and the District of Columbia, and the term ‘‘U.S. person’’ means any individual who
is a citizen or resident of the United States for U.S. federal income tax purposes, a corporation, partnership or other entity
created or organized in or under the laws of the United States, any state of the United States or the District of Columbia, or
any estate or trust the income of which is subject to U.S. federal income taxation regardless of its source.

 

Article
VI 

 

MISCELLANEOUS PROVISIONS

 

Section 6.1          
Ratification. The Indenture, as supplemented and amended by this Supplemental Indenture, is in all respects hereby
adopted, ratified and confirmed.

 

Section 6.2          
Counterparts. This Supplemental Indenture may be executed in any number of counterparts and the signatories of all
parties need not appear on the same counterpart. Each counterpart, when executed and delivered, shall be deemed an original, but
all such counterparts when taken together shall constitute a single instrument. The delivery of signed counterparts by facsimile
or email transmission that includes a copy of the sending party’s signature is as effective as signing and delivering the
counterpart in person.

 

Section 6.3          Governing
Law. THIS SUPPLEMENTAL INDENTURE AND EACH NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE
OF NEW YORK.

 

Section 6.4           Conflict with Trust Indenture Act. If any provision hereof limits, qualifies or conflicts with a provision of the
Trust Indenture Act that is required under such Act to be a part of and govern this Supplemental Indenture, the latter provision
shall control. If any provision of this Supplemental Indenture modifies or excludes any provision of the Trust Indenture Act that
may be so modified or excluded, the latter provision shall be deemed to apply to this Supplemental Indenture as so modified or
to be excluded, as the case may be.

 

Section 6.5           The Trustee. The recitals contained herein and in the Securities, except the Trustee’s certificates of authentication,
shall be taken as the statements of the Company, and the Trustee assumes no responsibility for their correctness. The Trustee
makes no representations as to the validity or sufficiency of this Supplemental Indenture or of the Securities.

 

[signature page follows]

 

    16

     

    

 

IN WITNESS WHEREOF,
the parties hereto have caused this Supplemental Indenture No. 6 to be duly executed as of the day
and year first above written.

 

	 	ABBVIE INC.
	 	 
	 	By:	/s/ Tabetha A. Skarbek
	 	 	 	Name: Tabetha A. Skarbek
 Title: Vice President and Treasurer
	 	 	 	 
	 	U.S. BANK NATIONAL ASSOCIATION,

 as Trustee
	 
	 	By:	/s/ Linda E. Garcia
	 	 	 	Name: Linda E. Garcia
 Title: Vice President
	 	 	 	 
	 	ELAVON FINANCIAL SERVICES DAC,

 U.K. Branch, as Paying Agent
	 
	 	By:	/s/ David Harnett
	 	 	 	Name: David Harnett
 Title: Authorised Signatory
	 	 	 	 
	 	By:	/s/ Michael Leong
	 	 	 	Name: Michael Leong
 Title: Authorised Signatory
	 	 	 	 
	 	US BANK NATIONAL ASSOCIATION,

 as Transfer Agent and Registrar
	 	 
	 	By:	/s/ Linda E. Garcia
	 	 	 	Name: Linda E. Garcia
 Title: Vice President

 

[Signature Page to Supplemental Indenture No. 6]

 

    17

     

    

 

 

EXHIBIT A1 – Form of 0.750% Senior
Notes due 2027

 

ABBVIE INC.

 

0.750% Senior Notes due 2027

 

	No. [001]	 	€750,000,000

 

CUSIP: U0029Q AK2 

 

ISIN: XS2055646918

 

COMMON CODE: 205564691

 

This Security is a
Security in a global form within the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common
Depositary”) for Euroclear Bank SA/NV (“Euroclear”)
and Clearstream Banking S.A. (“Clearstream, Luxembourg”), unless and
until this Security is exchanged in whole or in part for Securities in definitive, certificated form, this Security may not be
transferred except as a whole by the Common Depositary to a nominee thereof or by a nominee thereof to the Common Depositary or
another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary to a successor Common
Depositary or a nominee of such successor Common Depositary. This global Security is exchangeable for Securities registered in
the name of a Person other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture,
and no transfer of this Security (other than a transfer of this Security as a whole as described above) may be registered except
in such limited circumstances.

 

    A-1-1

     

    

 

ABBVIE INC.

 

ABBVIE INC., a corporation
duly organized and existing under the laws of Delaware (herein called the “Company,”
which term includes any successor Person under the Indenture and Supplemental Indenture hereinafter referred to), for value received,
hereby promises to pay to USB Nominees (UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common
Depositary”) for Euroclear Bank SA/NV (“Euroclear”)
and Clearstream Banking S.A. (“Clearstream, Luxembourg”), or registered
assigns, the principal sum of Seven Hundred Fifty Million Euro (€750,000,000), or such other principal sum as may be indicated
on the Schedule of Exchanges attached hereto, on November 18, 2027 and to pay interest thereon from September 26, 2019 or from
the most recent Interest Payment Date to which interest has been paid or duly provided for, annually in arrears on November 18
in each year, commencing November 18, 2019, at the rate of 0.750% per annum, until the principal hereof is paid or made available
for payment.

 

Interest on the Notes
shall be determined on the basis of the actual number of days in the period for which interest is being calculated, and including
the last date on which interest was paid or duly provided for on the Notes (or September 26, 2019, if no interest has been paid
on the Notes) to but excluding the next following Interest Payment Date. This payment convention is referred to as ACTUAL/ACTUAL
(ICMA) (as defined in the rulebook of the International Capital Market Association.)

 

The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person
in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is
the clearing system business day (which for these purposes, is a day on which Euroclear and Clearstream, Luxembourg settle payments
in euro) immediately prior to the relevant interest payment date (such day, the “Record
Date”). For purposes of this Note, “Business Day”
means any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The City of New York or
London are authorized or required by law or executive order to close and (2) on which the Trans-European Automated Real-Time Gross
Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open.

 

Payments of principal
of, and premium, if any, and interest on, this Note, including payments made upon any redemption of this Note, shall be made by
wire transfer of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange
controls or other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or
if the euro is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their
currency or for the settlement of transactions by public institutions of or within the international banking community, then all
payments in respect of this Note shall be made in U.S. Dollars until the euro is again available to the Company or so used. In
such circumstances, the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S.
Federal Reserve Board as of the close of business on the second business day prior to the relevant payment date, or in the event
the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange
rate available on or prior to the second business day prior to the relevant payment date as determined by the Company in its sole
discretion. Any payment in respect of this Note so made in U.S. Dollars shall not constitute an Event of Default under this Note
or the Indenture. Neither the Trustee nor the Paying Agent (as defined below) shall have any responsibility for any calculation
or conversion in connection with the foregoing.

 

    A-1-2

     

    

 

Reference is hereby
made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes
have the same effect as if set forth at this place.

 

Unless the certificate
of authentication hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled
to any benefit under the Indenture or be valid or obligatory for any purpose.

 

    A-1-3

     

    

 

IN WITNESS WHEREOF,
the Company has caused this instrument to be duly executed.

 

	Dated: September 26, 2019
	 
	 	ABBVIE INC.
	 
	 	By:	 
	 	 	 	Name: Tabetha A. Skarbek
	 	 	 	Title: Vice President and Treasurer

 

    A-1-4

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the
Securities designated therein referred to in the within-mentioned Indenture.

 

	Dated: September 26, 2019	
	 	 
	 	U.S. BANK NATIONAL ASSOCIATION, as Trustee
	 	 
	 	By:	 
	 	 	 	Name:
	 	 	 	Title:

 

    A-1-5

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one
of a duly authorized issue of securities of the Company (herein called the “Securities”),
issued and to be issued in one or more series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended
from time to time (herein called the “Base Indenture”), between the
Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture) and Supplemental Indenture No. 6, dated as of September 26, 2019
(herein called the “Supplemental Indenture”), among the Company, the
Trustee, Elavon Financial Services DAC, U.K. Branch (the “Paying Agent”)
and U.S. Bank National Association, as transfer agent and registrar (the “Transfer
Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 6”, and together with the Base Indenture, the “Indenture”) to which Indenture and all
supplemental indentures thereto reference is hereby made for a statement of the respective rights, limitations of rights, duties
and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series and of the terms upon which
the Securities of this series are, and are to be, authenticated and delivered. This Security is one of the series designated on
the face hereof, in an initial aggregate principal amount of €750,000,000.

 

At any time prior to
the Par Call Date, the Company may redeem some or all of the Securities of this series, in each case at the Company’s option,
at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed;
and (ii) the sum of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose
that such Securities matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive
of interest accrued to the date of redemption) discounted to the date of redemption on an annual basis (ACTUAL/ACTUAL (ICMA)) at
the applicable Comparable Government Bond Rate plus 25 basis points, plus, accrued and unpaid interest on the principal amount
being redeemed to, but excluding, the date of redemption.

 

In addition, at any
time on or after the Par Call Date, the Company may redeem some or all of the Securities of this series, in each case at the Company’s
option, at a redemption price equal to 100% of the principal amount of the Securities of such series to be redeemed, plus, in each
case, accrued and unpaid interest on the principal amount being redeemed to, but excluding, the Redemption Date.

 

If the Company has
given notice as provided in the Indenture and funds for the redemption of any Securities of this series called for redemption have
been made available on the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the
date fixed for redemption. Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption
price.

 

The Company will give
notice of any optional redemption to and through Euroclear or Clearstream, Luxembourg for communication by them to the holders
of interests in this Security, not more than 60 nor less than 30 days prior to the date fixed for redemption. The notice of redemption
will specify, among other items, the Redemption Date, redemption price, the principal amount of the Securities of this series to
be redeemed and the place or places that payment will be made upon surrender of the Securities of this series to be redeemed.

 

    A-1-6

     

    

 

The Company will notify
the Trustee at least 45 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the
Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their relevant Redemption Date.
If less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance
with the rules of Euroclear and/or Clearstream, Luxembourg (to be reflected in the records of Euroclear and Clearstream, Luxembourg
as either a pool factor or a reduction in nominal amount, at their discretion).

 

“Business
Day” means any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The
City of New York or London are authorized or required by law or executive order to close and (2) on which the Trans-European Automated
Real-Time Gross Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open.

 

“Clearstream,
Luxembourg” means Clearstream Banking S.A.

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, Luxembourg, which
initially shall be Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an
Independent Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German
government bond”), whose maturity is closest to the maturity of the notes, or if the Independent Investment Bank
in its discretion determines that such similar bond is not in issue, such other German government bond as the Independent Investment
Bank may, with the advice of three brokers of, and/or market makers in, German government bonds selected by the Company, determine
to be appropriate for determining the Comparable Government Bond Rate.

 

“Comparable
Government Bond Rate” means the yield to maturity, expressed as a percentage (rounded to three decimal places,
with 0.0005 being rounded upwards), on the third business day prior to the date fixed for redemption, of the Comparable Government
Bond on the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business
Day as determined by an Independent Investment Bank.

 

“Corporate
Trust Office of the Paying Agent” means, initially, the office of Elavon Financial Services DAC, U.K. Branch located
at 125 Old Broad Street, London, EC2N 1AR, United Kingdom.

 

“Definitive
Note” means a certificated Note that does not include the Global Notes Legend.

 

“euro”
or “€” means the currency of the member states of the European
Monetary Union that have adopted or that adopt the single currency in accordance with the treaty establishing the European Community,
as amended by the Treaty on European Union.

 

“Euroclear”
means Euroclear Bank SA/NV.

 

“Global
Notes Legend” means the legend set forth in Exhibits A1 through A3 to this Supplemental Indenture.

 

    A-1-7

     

    

 

“Independent
Investment Bank” means an independent investment bank selected by the Company.

 

“Notes”
means the 2027 Notes and the 2031 Notes.

 

“Par Call
Date” means August 18, 2027 (three months prior to the maturity date of the 2027 Notes).

 

“U.S.
Dollar” or “$” means the lawful currency of the United
States of America.

 

The Securities of this
series do not provide for a sinking fund.

 

If an Event of Default
with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be
declared due and payable in the manner and with the effect provided in the Indenture.

 

The Indenture contains
provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of
Default with respect to this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and
13.3 of the Indenture apply to the Securities of this series.

 

The Indenture permits,
with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company
and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding
of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal
amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive
compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.
Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future
Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu
hereof, whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein
to the Indenture or Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall
alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and
interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register,
upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal
of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized
in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the
same aggregate principal amount, will be issued to the designated transferee or transferees.

 

    A-1-8

     

    

 

The Securities of this
series are issuable in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in
excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are
exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination,
as requested by the Holder surrendering the same.

 

No service charge shall
be made for any registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require
payment of a sum sufficient to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith
(other than any such transfer taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections
9.6 or 11.7 of the Indenture).

 

Prior to due presentment
of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat
the Person in whose name this Security is registered as the owner hereof for the purpose of receiving payments and for all other
purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.

 

All terms used in this
Security which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture
and Supplemental Indenture.

 

THIS SECURITY SHALL
BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a
Book-Entry Security within the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK)
Limited, as nominee of the Common Depositary for Euroclear and Clearstream, Luxembourg. This Security is exchangeable for Securities
registered in the name of a person other than the nominee of the Common Depositary only in the limited circumstances described
in the Indenture and may not be transferred except as a whole by the Common Depositary to a nominee of the Common Depository or
by a nominee of the Common Depositary to the Common Depositary or another nominee of the Common Depositary or by the Common Depositary
or a nominee of the Common Depositary to a successor Common Depositary or a nominee of such successor Common Depositary.

 

	*	 	*	 	*

 

    A-1-9

     

    

 

CERTIFICATE TO BE DELIVERED UPON EXCHANGE

OR REGISTRATION OF TRANSFER OF SECURITIES

 

This Certificate relates
to €___________ principal amount of Securities held in (check applicable space) ___ book-entry or ___ definitive form by ____________________
____________________________ (the “Transferor”).

 

The Transferor (check
one box below):

 

		[_]	has requested the Trustee by written order to deliver in exchange for its beneficial interest in
the global Security held by the Common Depository a Security or Securities in definitive, registered form of authorized denominations
in an aggregate principal amount equal to its beneficial interest in such global Security (or the portion thereof indicated above);
or

 

		[_]	has requested the Trustee by written order to exchange or register the transfer of a Security or
Securities.

 

	 	
	 	[INSERT NAME OF TRANSFEROR]

 

	Dated:
	 
	 	By:	 	 

 

    A-1-10

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges,
redemptions or purchases of a part of this Book-Entry Security have been made:

 

	Date of Exchange/

 Redemption/ 

Repurchase	 	Amount of

                                                                                decrease in 

Principal Amount

 of this Book-Entry

 Security
	 	Amount of

 increase in 

Principal Amount 

of this Book-Entry 

Security	 	Principal Amount 

of this Book-Entry

 Security following

 such decrease (or

 increase)	 	Signature of

 authorized

 signatory of 

Trustee
	 	 	 	 	 	 	 	 	 

 

    A-1-11

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form
below:

 

I or we assign and transfer this Security
to

 

	 
	(Print or type assignee’s name, address and zip code)
	 

	 
	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint _______________________________
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

	Date:	 	 
	 
	Your Signature:

 

	By:	 	 
	Name:	 	 
	Title:	 	 

 

Sign exactly as your name appears on the
other side of this Security.

 

    A-1-12

     

    

 

EXHIBIT A2 – Form of 1.250% Senior
Notes due 2031

 

ABBVIE INC.

 

1.250% Senior Notes due 2031

 

	No. [001]	 	€650,000,000

 

CUSIP: U0029Q AJ5 

 

ISIN: XS2055647213

 

COMMON CODE: 205564721

 

This Security is a
Security in a global form within the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees
(UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common
Depositary”) for Euroclear Bank SA/NV (“Euroclear”)
and Clearstream Banking S.A. (“Clearstream, Luxembourg”), unless and
until this Security is exchanged in whole or in part for Securities in definitive, certificated form, this Security may not be
transferred except as a whole by the Common Depositary to a nominee thereof or by a nominee thereof to the Common Depositary or
another nominee of the Common Depositary or by the Common Depositary or a nominee of the Common Depositary to a successor Common
Depositary or a nominee of such successor Common Depositary. This global Security is exchangeable for Securities registered in
the name of a Person other than the nominee of the Common Depositary only in the limited circumstances described in the Indenture,
and no transfer of this Security (other than a transfer of this Security as a whole as described above) may be registered except
in such limited circumstances.

 

    A-2-1

     

    

 

ABBVIE INC.

 

ABBVIE INC., a corporation
duly organized and existing under the laws of Delaware (herein called the “Company,”
which term includes any successor Person under the Indenture and Supplemental Indenture hereinafter referred to), for value received,
hereby promises to pay to USB Nominees (UK) Limited, as nominee of Elavon Financial Services DAC, as common depositary (the “Common
Depositary”) for Euroclear Bank SA/NV (“Euroclear”)
and Clearstream Banking S.A. (“Clearstream, Luxembourg”), or registered
assigns, the principal sum of Six Hundred Fifty Million Euro (€650,000,000), or such other principal sum as may be indicated
on the Schedule of Exchanges attached hereto, on November 18, 2031 and to pay interest thereon from September 26, 2019 or from
the most recent Interest Payment Date to which interest has been paid or duly provided for, annually in arrears on November 18,
in each year, commencing November 18, 2019, at the rate of 1.250% per annum, until the principal hereof is paid or made available
for payment.

 

Interest on the Notes
shall be determined on the basis of the actual number of days in the period for which interest is being calculated, and including
the last date on which interest was paid or duly provided for on the Notes (or September 26, 2019, if no interest has been paid
on the Notes) to but excluding the next following Interest Payment Date. This payment convention is referred to as ACTUAL/ACTUAL
(ICMA) (as defined in the rulebook of the International Capital Market Association.)

 

The interest so payable,
and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person
in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the date that is
the clearing system business day (which for these purposes, is a day on which Euroclear and Clearstream, Luxembourg settle payments
in euro) immediately prior to the relevant interest payment date (such day, the “Record
Date”). For purposes of this Note, “Business Day”
means any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The City of New York or
London are authorized or required by law or executive order to close and (2) on which the Trans-European Automated Real-Time Gross
Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open.

 

Payments of principal
of, and premium, if any, and interest on, this Note, including payments made upon any redemption of this Note, shall be made by
wire transfer of immediately available funds in euro. If the euro is unavailable to the Company due to the imposition of exchange
controls or other circumstances beyond the Company’s control (including the dissolution of the European Monetary Union) or
if the euro is no longer being used by the then member states of the European Monetary Union that have adopted the euro as their
currency or for the settlement of transactions by public institutions of or within the international banking community, then all
payments in respect of this Note shall be made in U.S. Dollars until the euro is again available to the Company or so used. In
such circumstances, the amount payable on any date in euro shall be converted into U.S. Dollars at the rate mandated by the U.S.
Federal Reserve Board as of the close of business on the second business day prior to the relevant payment date, or in the event
the U.S. Federal Reserve Board has not mandated a rate of conversion, on the basis of the then most recent U.S. Dollar/euro exchange
rate available on or prior to the second business day prior to the relevant payment date as determined by the Company in its sole
discretion. Any payment in respect of this Note so made in U.S. Dollars shall not constitute an Event of Default under this Note
or the Indenture. Neither the Trustee nor the Paying Agent (as defined below) shall have any responsibility for any calculation
or conversion in connection with the foregoing.

 

    A-2-2

     

    

 

Reference is hereby
made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all purposes
have the same effect as if set forth at this place.

 

Unless the certificate
of authentication hereon has been executed by the Trustee referred to herein by manual signature, this Security shall not be entitled
to any benefit under the Indenture or be valid or obligatory for any purpose.

 

    A-2-3

     

    

 

IN WITNESS WHEREOF,
the Company has caused this instrument to be duly executed.

 

	Dated: September 26, 2019
	 
	 	ABBVIE INC.
	 
	 	By:	 
	 	 	 	Name: Tabetha A. Skarbek
	 	 	 	Title: Vice President and Treasurer

 

    A-2-4

     

    

 

TRUSTEE’S CERTIFICATE OF AUTHENTICATION

 

This is one of the
Securities designated therein referred to in the within-mentioned Indenture.

 

	Dated: September 26, 2019
	 
	 	U.S. BANK NATIONAL ASSOCIATION, as Trustee
	 
	 	By:	 
	 	 	 	Name:
	 	 	 	Title:

 

    A-2-5

     

    

 

[FORM OF REVERSE OF SECURITY]

 

This Security is one
of a duly authorized issue of securities of the Company (herein called the “Securities”),
issued and to be issued in one or more series under an Indenture, dated as of November 8, 2012, as it may be supplemented or amended
from time to time (herein called the “Base Indenture”), between the
Company and U.S. Bank National Association, as Trustee (herein called the “Trustee,”
which term includes any successor trustee under the Indenture) and Supplemental Indenture No. 6, dated as of September 26, 2019
(herein called the “Supplemental Indenture”), among the Company, the
Trustee, Elavon Financial Services DAC, U.K. Branch (the “Paying Agent”)
and U.S. Bank National Association, as transfer agent and registrar (the “Transfer
Agent” and “Security Registrar”) (the “Supplemental
Indenture No. 6”, and together with the Base Indenture, the “Indenture”) to which Indenture
and all supplemental indentures thereto reference is hereby made for a statement of the respective rights, limitations of rights,
duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities of this series and of the terms
upon which the Securities of this series are, and are to be, authenticated and delivered. This Security is one of the series designated
on the face hereof, in an initial aggregate principal amount of €650,000,000.

 

At any time prior to
the Par Call Date, the Company may redeem some or all of the Securities of this series, in each case at the Company’s option,
at a redemption price equal to the greater of: (i) 100% of the principal amount of the Securities of this series to be redeemed;
and (ii) the sum of the present values of the remaining scheduled payments (through the Par Call Date assuming for such purpose
that such Securities matured on the Par Call Date) of principal and interest on the Securities of this series to be redeemed (exclusive
of interest accrued to the date of redemption) discounted to the date of redemption on an annual basis (ACTUAL/ACTUAL (ICMA)) at
the applicable Comparable Government Bond Rate plus 30 basis points, plus, accrued and unpaid interest on the principal amount
being redeemed to, but excluding, the date of redemption.

 

In addition, at any
time on or after the Par Call Date, the Company may redeem some or all of the Securities of this series, in each case at the Company’s
option, at a redemption price equal to 100% of the principal amount of the Securities of such series to be redeemed, plus, in each
case, accrued and unpaid interest on the principal amount being redeemed to, but excluding, the Redemption Date.

 

If the Company has
given notice as provided in the Indenture and funds for the redemption of any Securities of this series called for redemption have
been made available on the Redemption Date in accordance with the Indenture, such Securities will cease to bear interest on the
date fixed for redemption. Thereafter, the only right of the Holders of such Securities will be to receive payment of the redemption
price.

 

The Company will give
notice of any optional redemption to and through Euroclear or Clearstream, Luxembourg for communication by them to the holders
of interests in this Security, not more than 60 nor less than 30 days prior to the date fixed for redemption. The notice of redemption
will specify, among other items, the Redemption Date, redemption price, the principal amount of the Securities of this series to
be redeemed and the place or places that payment will be made upon surrender of the Securities of this series to be redeemed.

 

    A-2-6

     

    

 

The Company will notify
the Trustee at least 45 days prior to the Redemption Date fixed by the Company (or such shorter period as is satisfactory to the
Trustee) of the aggregate principal amount of the Securities of this series to be redeemed and their relevant Redemption Date.
If less than all of the Securities of this series are to be redeemed at any time, the Securities will be selected in accordance
with the rules of Euroclear and/or Clearstream, Luxembourg (to be reflected in the records of Euroclear and Clearstream, Luxembourg
as either a pool factor or a reduction in nominal amount, at their discretion).

 

“Business
Day” means any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The
City of New York or London are authorized or required by law or executive order to close and (2) on which the Trans-European Automated
Real-Time Gross Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open.

 

“Clearstream,
Luxembourg” means Clearstream Banking S.A.

 

“Common
Depositary” means any Person acting as the common depositary for Euroclear and Clearstream, Luxembourg, which
initially shall be Elavon Financial Services DAC.

 

“Comparable
Government Bond” means, in relation to any Comparable Government Bond Rate calculation, at the discretion of an
Independent Investment Bank, a bond that is a direct obligation of the Federal Republic of Germany (“German
government bond”), whose maturity is closest to the maturity of the notes, or if the Independent Investment Bank
in its discretion determines that such similar bond is not in issue, such other German government bond as the Independent Investment
Bank may, with the advice of three brokers of, and/or market makers in, German government bonds selected by the Company, determine
to be appropriate for determining the Comparable Government Bond Rate.

 

“Comparable
Government Bond Rate” means the yield to maturity, expressed as a percentage (rounded to three decimal places,
with 0.0005 being rounded upwards), on the third business day prior to the date fixed for redemption, of the Comparable Government
Bond on the basis of the middle market price of the Comparable Government Bond prevailing at 11:00 a.m. (London time) on such Business
Day as determined by an Independent Investment Bank.

 

“Corporate
Trust Office of the Paying Agent” means, initially, the office of Elavon Financial Services DAC, U.K. Branch located
at 125 Old Broad Street, London, EC2N 1AR, United Kingdom.

 

“Definitive
Note” means a certificated Note that does not include the Global Notes Legend.

 

“euro”
or “€” means the currency of the member states of the European
Monetary Union that have adopted or that adopt the single currency in accordance with the treaty establishing the European Community,
as amended by the Treaty on European Union.

 

“Euroclear”
means Euroclear Bank SA/NV.

 

“Global
Notes Legend” means the legend set forth in Exhibits A1 through A3 to this Supplemental Indenture.

 

    A-2-7

     

    

 

“Independent
Investment Bank” means an independent investment bank selected by the Company.

 

“Notes”
means the 2027 Notes and the 31 Notes.

 

“Par Call
Date” means August 18, 2031 (three months prior to the maturity date of the 2031 Notes).

 

“U.S.
Dollar” or “$” means the lawful currency of the United
States of America.

 

The Securities of this
series do not provide for a sinking fund.

 

If an Event of Default
with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be
declared due and payable in the manner and with the effect provided in the Indenture.

 

The Indenture contains
provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and Events of
Default with respect to this Security, in each case upon compliance with certain conditions set forth therein. Sections 13.2 and
13.3 of the Indenture apply to the Securities of this series.

 

The Indenture permits,
with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company
and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and
the Trustee with the consent of the Holders of not less than a majority in principal amount of the Securities at the time Outstanding
of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal
amount of the Securities at the time Outstanding of any series, on behalf of the Holders of all Securities of such series, to waive
compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences.
Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future
Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu
hereof, whether or not notation of such consent or waiver is made upon this Security.

 

No reference herein
to the Indenture or Supplemental Indenture and no provision of this Security or of the Indenture or Supplemental Indenture shall
alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and
interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed.

 

As provided in the
Indenture and subject to certain limitations therein set forth, the transfer of this Security is registerable in the Security Register,
upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal
of and any premium and interest on this Security are payable, duly endorsed by, or accompanied by a written instrument of transfer
in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized
in writing, and thereupon one or more new Securities of this series and of like tenor, of authorized denominations and for the
same aggregate principal amount, will be issued to the designated transferee or transferees.

 

    A-2-8

     

    

 

The Securities of this
series are issuable in fully registered form only in denominations of €100,000 and any integral multiple of €1,000 in
excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are
exchangeable for a like aggregate principal amount of Securities of this series and of like tenor of a different authorized denomination,
as requested by the Holder surrendering the same.

 

No service charge shall
be made for any registration of transfer or exchange of the Notes, but the Company or the Security Registrar may require
payment of a sum sufficient to cover any transfer tax, assessments, or similar governmental charge payable in connection therewith
(other than any such transfer taxes, assessments or similar governmental charge payable upon exchange or transfer pursuant to Sections
9.6 or 11.7 of the Indenture).

 

Prior to due presentment
of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee will treat
the Person in whose name this Security is registered as the owner hereof for the purpose of receiving payments and for all other
purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by
notice to the contrary.

 

All terms used in this
Security which are defined in the Indenture and Supplemental Indenture shall have the meanings assigned to them in the Indenture
and Supplemental Indenture.

 

THIS SECURITY SHALL
BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK.

 

This Security is a
Book-Entry Security within the meaning of the Indenture hereinafter referred to and is registered in the name of USB Nominees (UK)
Limited, as nominee of the Common Depositary for Euroclear and Clearstream, Luxembourg. This Security is exchangeable for Securities
registered in the name of a person other than the nominee of the Common Depositary only in the limited circumstances described
in the Indenture and may not be transferred except as a whole by the Common Depositary to a nominee of the Common Depository or
by a nominee of the Common Depositary to the Common Depositary or another nominee of the Common Depositary or by the Common Depositary
or a nominee of the Common Depositary to a successor Common Depositary or a nominee of such successor Common Depositary.

 

	*	 	*	 	*

 

    A-2-9

     

    

 

CERTIFICATE TO BE DELIVERED UPON EXCHANGE

OR REGISTRATION OF TRANSFER OF SECURITIES

 

This Certificate relates
to €___________ principal amount of Securities held in (check applicable space) ___ book-entry or ___ definitive form by ____________________
____________________________ (the “Transferor”).

 

The Transferor (check
one box below):

 

		[_]	has requested the Trustee by written order to deliver in exchange for its beneficial interest in
the global Security held by the Common Depository a Security or Securities in definitive, registered form of authorized denominations
in an aggregate principal amount equal to its beneficial interest in such global Security (or the portion thereof indicated above);
or

 

		[_]	has requested the Trustee by written order to exchange or register the transfer of a Security or
Securities.

 

	 	 
	 	[INSERT NAME OF TRANSFEROR]

 

	Dated:
	 
	 	By:	 	 

 

    A-2-10

     

    

 

SCHEDULE OF EXCHANGES

 

The following exchanges,
redemptions or purchases of a part of this Book-Entry Security have been made:

 

	Date of Exchange/

 Redemption/

 Repurchase	 	Amount of

 decrease in

 Principal Amount

 of this Book-Entry

 Security	 	Amount of 

increase in 

Principal Amount

 of this Book-Entry 

Security	 	Principal Amount 

of this Book-Entry

 Security following 

such decrease (or

 increase)	 	Signature of 

authorized 

signatory of 

Trustee
	 	 	 	 	 	 	 	 	 

 

    A-2-11

     

    

 

ASSIGNMENT FORM

 

To assign this Security, fill in the form
below:

 

I or we assign and transfer this Security
to

 

	 
	(Print or type assignee’s name, address and zip code)
	 

	 
	(Insert assignee’s soc. sec. or tax I.D. No.)

 

and irrevocably appoint _______________________________
as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

 

	Date:	 	 
	 
	Your Signature:

 

	By:	 	 
	Name:	 	 
	Title:	 	 

 

Sign exactly as your name appears on the
other side of this Security.

 

    A-2-12Exhibit 4.3

 

EXECUTION VERSION 

 

Dated
September 26, 2019

 

 

 

ISSUER

 

 

PAYING AGENT

 

  

TRANSFER AGENT

 

  

REGISTRAR

 

 

  

- AND-

 

 

  

TRUSTEE

 

 

 

 

 

 

 

 

 

 

  

AGENCY AGREEMENT

 

relating to Notes issued under a

prospectus dated September 13, 2018, as supplemented by the prospectus supplement dated

September 17, 2019

 

     

     

    

 

CONTENTS

 

	CLAUSE	PAGE
	 	 
	1.	Interpretation	4
	2.	Appointment Of The Registrar	4
	3.	Appointment Of The Transfer Agent	4
	4.	Appointment Of Paying Agent	4
	5.	Authentication And Delivery Of Notes	5
	6.	Payment	5
	7.	Repayment	6
	8.	Prepayment; Notice Of Withholding Or Deduction	6
	9.	Duties Of The Paying Agent In Connection With Optional Redemption And Redemption For Taxation Reasons	7
	10.	Cancellation Of Notes	7
	11.	Issue Of Replacement Notes	7
	12.	Records	7
	13.	Fees And Expenses	8
	14.	Indemnity	8
	15.	Conditions Of Appointment	8
	16.	Changes In Paying Agent Or Registrar And Specified Offices	11
	17.	Notices	12
	18.	Communications	12
	19.	Amendments	14
	20.	Taxes	14
	21.	Regulatory Matters	14
	22.	Governing Law And Jurisdiction	16
	23.	COUNTERPARTS	16
	APPENDIX 1	18

 

     

     

    

 

THIS AGREEMENT is made on September 26, 2019

 

BETWEEN:

 

		(1)	ABBVIE INC., a Delaware corporation, registered number 32-0375147, with its registered office at
1 North Waukegan Road, North Chicago, Illinois 60064, USA (the “Issuer”);

 

		(2)	ELAVON FINANCIAL SERVICES DAC, a designated activity company registered in Ireland with the Companies
Registration Office, registered number 418442, with its registered office at 2nd Floor, Block E, Cherrywood Science & Technology
Park, Loughlinstown, Co. Dublin, Ireland, acting through its UK Branch (registered number BR009373) from its offices at 125 Old
Broad Street, Fifth Floor, London EC2N 1AR under the trade name U.S. Bank Global Corporate Trust Services, as Paying Agent (the
“Paying Agent” which expression shall include any successor paying agent appointed in accordance with this Agreement);

 

		(3)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York, as Transfer Agent (the “Transfer
Agent” which expression shall include any successor transfer agent appointed in accordance with this Agreement);

 

		(4)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York, as Registrar (the “Registrar”
which expression shall include any successor registrar appointed in accordance with this Agreement); and

 

		(5)	U.S. BANK NATIONAL ASSOCIATION, a national banking association chartered under the federal laws
of the United States of America with its main office at 100 Wall Street, New York, New York as Trustee (the “Trustee”).

 

WHEREAS:

 

		(A)	The Issuer has agreed to issue 0.750% Senior Notes due 2027 (the “2027 Notes”)
and 1.250% Senior Notes due 2031 (the “2031 Notes” and, together with the 2027 Notes, the “Notes”).
The Notes will initially be represented by one or more global notes in registered form (the “Global Notes”).

 

		(B)	The Notes are to be constituted by an indenture dated November 8, 2012 (the “Base Indenture”),
as supplemented by the Supplemental Indenture No. 6 dated September 26, 2019 (the “Supplemental Indenture,”
and together with the Base Indenture, the “Indenture”), as set out in Appendix 1.

 

		(C)	The Issuer hereby appoints the Paying Agent, the Transfer Agent and the Registrar in accordance
with the terms of this Agreement and the Indenture.

 

     

     

    

 

IT IS AGREED:

 

		1.	Interpretation

 

		1.1	Unless the context otherwise requires:

 

		1.2	References in this Agreement to the payment of principal or interest in respect of any Note shall
be deemed to include any additional amounts which may become payable in respect thereof pursuant to the Notes and the Indenture.

 

		1.3	All references in this Agreement to an agreement, instrument or other document (including this
Agreement, the Indenture and the Notes) shall be construed as a reference to that agreement, instrument or document as the same
may be amended, modified, varied, supplemented or novated from time to time.

 

		1.4	Except as specifically set forth in this Agreement, this Agreement is for the exclusive benefit
of the parties to this Agreement and their respective permitted successors, and shall not be deemed to give, either expressly or
implicitly, any legal or equitable right, remedy, or claim to any other entity or person whatsoever.

 

		2.	Appointment of the Registrar

 

		2.1	The Issuer hereby appoints the Registrar, and the Registrar hereby agrees to act at its specified
office as registrar in relation to the Notes in accordance with the provisions of this Agreement and the Indenture and upon the
terms and subject to the conditions contained in this Agreement and the Indenture.

 

		2.2	On the date of this Agreement, the Registrar shall provide to the Paying Agent a complete and correct
copy of the register maintained by the Registrar in respect of the holders of Notes and the outstanding principal amount of Notes
held by each holder of Notes.

 

		2.3	The Registrar shall from time to time provide to the Paying Agent a complete and correct copy of
the register of Notes maintained by it as soon as reasonably practicable following any transfer or exchange of any Notes, and promptly
on request therefor by the Paying Agent.

 

		2.4	The Paying Agent shall be entitled to treat as conclusive the most recent copy of the register
provided to it by the Registrar in accordance with this Agreement.

 

		3.	Appointment of the Transfer Agent

 

		3.1	The Transfer Agent is hereby appointed as the agent of the Issuer, to act as Transfer Agent for
the purposes specified in this Agreement, the Indenture and the Notes, including, inter alia, completing, authenticating, holding
and delivering Notes, upon the terms and subject to the conditions specified herein, the Indenture and in the Notes, and the Transfer
Agent hereby accepts such appointment.

 

		4.	Appointment of Paying Agent

 

		4.1	The Issuer hereby appoints the Paying Agent, and the Paying Agent hereby agrees, to act at its
specified office as paying agent in relation to the Notes in accordance with the provisions of this Agreement and the Indenture
and upon the terms and subject to the conditions contained in this Agreement and the Indenture.

 

		4.2	The Paying Agent is appointed hereunder for the purposes of:

 

		(a)	paying sums due on the Notes referred to in the Supplemental Indenture; and

 

		(b)	otherwise fulfilling its duties and obligations as set out in this Agreement and the Indenture.

 

    4

     

    

 

		5.	Authentication and Delivery of Notes

 

		5.1	If a Global Note is to be exchanged in accordance with its terms for definitive notes, the Issuer
undertakes that it will deliver to, or to the order of, the Paying Agent, as soon as reasonably practicable and in any event not
later than 15 days before the relevant exchange is due to take place, definitive Notes in an aggregate principal amount of €1.4
billion or such lesser amount as is the principal amount of Notes represented by the Global Note to be issued in exchange for the
Global Note. Each definitive Note so delivered shall be duly executed on behalf of the Issuer.

 

		5.2	The Issuer authorises and instructs the Trustee to authenticate the Global Notes and any definitive
notes delivered pursuant to subclause 5.1 subject to and in accordance with Section 3.3 of the Indenture.

 

		5.3	The Issuer authorises and instructs the Paying Agent to cause interests in a Global Note to be
exchanged for definitive notes in accordance with their respective terms. Following the exchange of the last interest in a Global
Note, the Paying Agent shall deliver the relevant Global Note to the Trustee for cancellation in accordance with Section 3.9 of
the Indenture.

 

		6.	Payment

 

Subject always to the Indenture
and, in particular, any restrictions on the Issuer following delivery of a notice of an Event of Default:

 

		(a)	The Issuer shall, not later than 10.00 am (London time) on a day on which any payment in respect
of the Notes becomes due, pay to such account of the Paying Agent as the Paying Agent shall specify in Euros in immediately available
funds on each due date for the payment of principal and/or interest and/or other amounts referred to in Section 3.1 of the Indenture
in respect of the Notes, an amount sufficient (together with any funds then held by the Paying Agent and available for the purpose)
to pay all principal and interest and/or other amounts referred to in Section 3.1 of the Indenture due in respect of the Notes
on such date.

 

		(b)	The Issuer hereby authorises and directs the Paying Agent from funds so paid to the Paying Agent
to make payment of all amounts due on the Notes in accordance with the terms of the Notes, the Indenture and the provisions of
this Agreement. If any payment provided for in clause 6(a) is made late but otherwise in accordance with the provisions of this
Agreement, the Paying Agent shall nevertheless make payments in respect of the Notes as aforesaid following receipt by the Paying
Agent of such payment.

 

		(c)	If the Paying Agent has not, on the date on which any payment is due to be made to the Paying Agent
pursuant to clause 6(a), received the full amount payable in respect thereof on such date but receives such full amount later,
together with accrued interest (if any) in accordance with the Indenture, it shall forthwith so notify the Issuer and the Trustee.
Unless and until the full amount of any such principal or interest payment has been made to it, the Paying Agent will not be bound
to make such payments.

 

		(d)	Without prejudice to clause 6(b), if the Paying Agent pays out on or after the due date therefor
to persons entitled thereto, or becomes liable to pay out, any amounts on the assumption (which is not negated by reasonable evidence
to the contrary) that the corresponding payment by the Issuer has been or will be made, the Issuer shall on demand reimburse the
Paying Agent for the relevant amount, and pay interest to the Paying Agent on such amount from (and including) the date on which
it is paid out to (but excluding) the date of reimbursement at the rate per annum equal to the cost to the Paying Agent of funding
the amount paid out, as certified by the Paying Agent and expressed as a rate per annum.

 

    5

     

    

 

		(e)	Payment of only part of the amount payable in respect of a Note may only be made at the discretion
of the relevant Noteholder(s) (except as the result of a withholding or deduction for or on account of any taxes permitted by the
Indenture). If at any time a Paying Agent makes a partial payment in respect of any Note presented to it, it shall inform the Registrar
of the same such that the Registrar may record the same on the register of Notes.

 

		7.	Repayment

 

Any sums paid by, or by arrangement
with the Issuer to the Paying Agent pursuant to the terms of this Agreement shall not be required to be repaid to the Issuer unless
and until the Notes in respect of which such sums were paid shall have been purchased by the Issuer or any other subsidiary of
the Issuer and cancelled, but in any of these events the Paying Agent shall (provided that all other amounts due under this Agreement
shall have been duly paid) upon written request by the Issuer forthwith repay to the Issuer sums equivalent to the amounts which
would otherwise have been payable on the relevant Notes together with any fees previously paid to the Paying Agent in respect of
such Notes. Notwithstanding the foregoing, the Paying Agent shall not be obliged to make any repayment to the Issuer so long as
any amounts which under this Agreement should have been paid to or to the order of the Paying Agent by the Issuer shall remain
unpaid. The Paying Agent shall not, however, be otherwise required or entitled to repay any sums properly received by it under
this Agreement.

 

		8.	Prepayment; Notice of Withholding or Deduction

 

		8.1	The Issuer shall provide to the Paying Agent a copy of all notices of redemption delivered under
the Indenture in respect of the Notes that it serves on the holders of the Notes including, without limitation, details of the
date(s) on which such redemptions in respect of the Notes are to be made, all amounts required to be paid by the Issuer in respect
thereof in accordance with the Indenture and the manner in which such redemption will be effected.

 

		8.2	If:

 

		(a)	the Issuer, in respect of any payment; or

 

		(b)	the Paying Agent, in respect of any payment of principal of or any premium or interest on the Notes,
is required to withhold or deduct any amount for or on account of Tax,

 

		(c)	the Issuer shall give notice thereof to the Paying Agent and the Trustee as soon as it becomes
aware of such requirement and shall give to the Paying Agent such information as the Paying Agent requires to enable it to make
such deduction or withholding; and

 

		(d)	except where such requirement arises as a result of prepayment of the Notes in accordance with
the Indenture or by virtue of the relevant holder failing to satisfy any certification or other requirement in respect of its Notes,
the Paying Agent shall give notice thereof to the Issuer and the Trustee as soon as it becomes aware of the requirement to withhold
or deduct.

 

In the event that the Issuer determines
in its sole discretion that withholding will be required by applicable law in connection with any payment due to the Paying Agent
on any Notes, then the Issuer will be entitled to redirect or reorganise any such payment in any way that it sees fit in order
that the payment may be made without such withholding provided that, any such redirected or reorganised payment is made through
a recognised institution of international standing and otherwise made in accordance with this Agreement and the Indenture. The
Issuer will promptly notify the Paying Agent and the Trustee of any such redirection or reorganisation.

 

    6

     

    

 

		9.	Duties of the Paying Agent in Connection With Optional Redemption and Redemption for Taxation Reasons

 

		9.1	If the Issuer decides to redeem all or some only of the Notes for the time being outstanding under
the Indenture, it shall give notice of the decision and of the relevant redemption date and of the principal amount of Notes which
it has decided to redeem, to the Paying Agent, and the Trustee at least 45 days (unless a shorter notice shall be satisfactory
to the Paying Agent and the Trustee) before the relevant redemption date.

 

		9.2	The Issuer (or, as the case may be, the Trustee) shall before or at the same time it notifies holders
of the Notes, notify the Registrar, the Transfer Agent and the Paying Agent of the serial numbers of any Notes drawn for redemption
and shall notify the Registrar, the Transfer Agent and the Paying Agent of the date fixed for redemption subject to and in accordance
with Section 11.4 of the Indenture.

 

		10.	Cancellation of Notes

 

		10.1	All Notes which are surrendered in connection with redemption or purchase shall be cancelled by
the Trustee in accordance with Section 3.9 of the Indenture.

 

		11.	Issue of Replacement Notes

 

		11.1	The Trustee shall, on issuing any replacement definitive note, forthwith inform the Issuer and
the Transfer Agent of the serial number of the replacement definitive note issued and (if known) of the serial number of the definitive
note in place of which the replacement definitive note has been issued.

 

		11.2	Whenever a definitive note for which a replacement definitive note has been issued is presented
to the Paying Agent for payment of principal or a Transfer Agent for transfer, the relevant agent shall immediately send notice
to the Issuer and (if it is not itself the Paying Agent) the Paying Agent.

 

		12.	Records

 

The Paying Agent shall:

 

		(a)	keep a full and complete record of all payments made by it in respect of the Notes; and

 

		(b)	make such records available at all reasonable times to the Issuer and any persons authorised by
it, and the Trustee for inspection and for the taking of copies thereof.

 

    7

     

    

 

		13.	Fees And Expenses

 

		13.1	The Issuer will pay to the Paying Agent, Transfer Agent and Registrar such fees and expenses in
respect of the Paying Agent, Transfer Agent and Registrar’s services under this Agreement as agreed to in the fee letter
dated September 16, 2019 from the Paying Agent, Transfer Agent and Registrar to, and countersigned by, the Issuer.

 

		13.2	The Issuer will also pay on demand, against presentation of such invoices and receipts as it may
reasonably require, all out-of-pocket expenses (including necessary advertising, facsimile and telex transmission, postage and
insurance expenses and, subject to prior approval by the Issuer as set forth below, the fees and expenses of legal advisers) properly
incurred by the Paying Agent, Transfer Agent and Registrar in connection with the services under this Agreement, together with
any applicable value added tax or similar tax properly chargeable thereon. Payment by the Issuer to the Paying Agent, Transfer
Agent and Registrar of such out-of-pocket expenses shall be a good discharge of the obligations of the Issuer in respect thereof.
Where the advice of legal counsel is sought by the Paying Agent, Transfer Agent or Registrar, the fees of any such counsel shall
be agreed to by the Issuer (acting reasonably) in advance.

 

		14.	Indemnity

 

		14.1	The Issuer undertakes to indemnify and hold harmless, the Paying Agent, Transfer Agent, Registrar
and each of its respective directors, officers, employees or agents (each an “Indemnified Party”) on demand
by such Indemnified Party against any losses, liabilities, costs, fees, expenses, claims, actions, damages or demands (including,
but not limited to, all reasonable costs, charges and expenses paid or incurred in disputing or defending the foregoing and the
properly incurred fees and expenses of legal advisers) which such Indemnified Party may incur or which may be made against it,
as a result of or in connection with the appointment or the exercise of or performance of its powers and duties under this Agreement,
except such as may result from its own gross negligence, wilful misconduct or fraud or that of its directors, officers, employees
or agents.

 

		14.2	The indemnity contained in clause 14.1 above shall survive the termination and expiry of this Agreement.

 

		15.	Conditions of Appointment

 

		15.1	The Paying Agent shall (a) hold all sums receives from Issuer in accordance with this Agreement
and the Indenture for payment of principal of or any premium or interest on the Notes in trust for the benefit of the Trustee until
such sums shall be paid to such persons or otherwise disposed of as provided in this Agreement and the Indenture; (b) give the
Trustee notice of any default by the Issuer (or any other obligor upon the Notes) in the making of any payment of principal of
or premium or interest on the Notes; and (c) at any time during the continuance of any such default, upon the written request of
the Trustee, forthwith pay to the Trustee all sums held by it in trust for payment in respect of the Notes.

 

		15.2	No monies held by the Paying Agent need be segregated except as required by law.

 

		15.3	In acting under this Agreement and in connection with the Notes, the Paying Agent, Transfer Agent
and Registrar shall act solely as agent of the Issuer and, save solely in respect of its obligations under clause 15.1 hereof,
shall not have any obligations towards or relationship of agency or trust with any of the holders of the Notes or the Trustee.

 

    8

     

    

 

		15.4	The Paying Agent, Transfer Agent and Registrar shall be obliged to perform such duties and only
such duties as are specifically set out in this Agreement. No implied duties or obligations shall be read into such document. The
Paying Agent, Transfer Agent and Registrar shall not be obliged to perform any duties additional to or different from such duties
resulting from any modification or supplement after the date hereof to any relevant documents (including, without limitation, the
Indenture), unless it shall have previously agreed to perform such duties. The Paying Agent, Transfer Agent and Registrar shall
not be under any obligation to take any action hereunder which either party expects, and has thus notified the Issuer in writing,
will result in any expense or liability of such Paying Agent, Transfer Agent or Registrar, the payment of which within a reasonable
time is not, in its opinion, assured to it.

 

		15.5	Except as ordered by a court of competent jurisdiction or as required by law, the Paying Agent
shall be entitled to treat the holder of any Note (as evidenced by the register of Notes maintained by the Registrar) as the absolute
owner thereof for all purposes (whether or not it is overdue and notwithstanding any notice to the contrary or any notice of ownership,
trust or any interest in it, any writing on it, or its theft or loss) and shall not be required to obtain any proof thereof or
as to the identity of the bearer or holder.

 

		15.6	The Paying Agent, Transfer Agent and Registrar may consult with any legal or other professional
advisers (who may be an employee of or legal adviser to the Issuer) selected by it, at the cost of the Issuer, provided that the
fees of any such counsel shall be agreed to by the Issuer (acting reasonably) in advance, and the opinion of such advisers shall
be full and complete protection in respect of any action taken, omitted or suffered hereunder in accordance with the written opinion
of such advisers.

 

		15.7	The Paying Agent, Transfer Agent and Registrar shall be protected and shall incur no liability
for or in respect of any action taken, suffered or omitted by it in reliance upon any instruction, request or order from the Issuer
or upon any Note, notice, resolution, direction, consent, certificate, affidavit, statement, telex, facsimile transmission or other
document or information from any electronic or other source reasonably believed by it to be genuine and to have been signed or
otherwise given or disseminated by the proper party or parties, even if it is subsequently found not to be genuine or to be incorrect.

 

		15.8	The Paying Agent, Transfer Agent and Registrar, whether acting for itself or in any other capacity,
will not be precluded from becoming the owner of, or acquiring any interest in, holding or disposing of any Note or any shares
or other securities of the Issuer or any of its subsidiaries, holding or associated companies (each a “Connected Company”),
with the same rights as it would have had if it were not acting as Paying Agent or from entering into or being interested in any
contracts or transactions with any Connected Company or from acting on, or as depositary, trustee or agent for, any committee or
body of holders of any securities of any Connected Company and will not be liable to account for any profit.

 

		15.9	The Paying Agent shall not be required to make any payments to any holder of a Note if under any
laws or regulations affecting the Paying Agent, such payment is not permitted. In the event of any such laws or regulations affecting
the Paying Agent coming to the attention of the Paying Agent it shall forthwith notify the Issuer and the Trustee.

 

		15.10	The Issuer shall do or cause to be done all such acts, matters and things and shall make available
all such documents as shall be necessary or desirable to enable the Paying Agent, Transfer Agent and Registrar to fully comply
with and carry out its respective duties and obligations hereunder.

 

    9

     

    

 

		15.11	In no event shall the Paying Agent, Transfer Agent or Registrar or any of its affiliates or any
of their respective officers, directors, employees, agents, advisors or representatives (collectively, “Agent Parties”)
have any liability for damages of any kind, including, without limitation, direct or indirect, special, incidental or consequential
damages, losses or expenses (whether in tort, contract or otherwise), except to the extent the liability of the Paying Agent, Transfer
Agent or Registrar is found in a final non-appealable judgment by a court of competent jurisdiction to have resulted primarily
from the gross negligence, wilful misconduct or fraud of the Paying Agent, Transfer Agent or Registrar or their Agent Parties.

 

		15.12	Notwithstanding anything contained in this Agreement to the contrary, the Paying Agent, Transfer
Agent and the Registrar shall not incur any liability for not performing any act or fulfilling any obligation hereunder by reason
of any occurrence beyond its control including, without limitation, (i) any governmental activity (whether de jure or de facto),
act of authority (whether lawful or unlawful), compliance with any governmental or regulatory order, rule, regulation or direction,
curfew restriction, expropriation, compulsory acquisition, seizure, requisition, nationalisation or the imposition of currency
or currency control restrictions; (ii) any failure of or the effect of rules or operations of any funds transfer, settlement or
clearing system, interruption, loss or malfunction of utilities, communications or computer services or the payment or repayment
of any cash or sums arising from the application of any law or regulation in effect now or in the future, or from the occurrence
of any event in the country in which such cash is held which may affect, limit, prohibit or prevent the transferability, convertibility,
availability, payment or repayment of any cash or sums until such time as such law, regulation or event shall no longer affect,
limit, prohibit or prevent such transferability, convertibility, availability, payment or repayment (and in no event, other than
as provided in the Notes, shall the Paying Agent be obliged to substitute another currency for a currency whose transferability,
convertibility or availability has been affected, limited, prohibited or prevented by such law, regulation or event or be obliged
to pay any penalty interest); (iii) any strike or work stoppage, go slow, occupation of premises, other industrial action or dispute
or any breach of contract by any essential personnel; (iv) any equipment or transmission failure or failure of applicable banking
or financial systems; (v) any war, armed conflict including but not limited to hostile attack, hostilities, or acts of a foreign
enemy; (vi) any riot, insurrection, civil commotion or disorder, mob violence or act of civil disobedience; (vii) any act of terrorism
or sabotage; (viii) any explosion, fire, destruction of machines, equipment or any kind of installation, prolonged breakdown of
transport, radioactive contamination, nuclear fusion or fission or electric current; (ix) any epidemic, natural disaster (such
as but not limited to violent storm, hurricane, blizzard, earthquake, landslide, tidal wave, flood, damage or destruction by lightning,
or drought); or (x) any other act of God.

 

		15.13	Pursuant to and in accordance with the procedures set forth in Section 10.3 of the Indenture (i)
the Issuer may at any time, for the purpose of obtaining the satisfaction and discharge of the Indenture or for any other purpose,
direct the Paying Agent to pay to the Trustee all sums held in trust by the Paying Agent, such sums to be held by the Trustee upon
the same trusts as those upon which such sums were held by the Paying Agent; and, upon such payment by the Paying Agent to the
Trustee, the Paying Agent shall be released from all further liability with respect to such money and (ii) any money deposited
with the Paying Agent in trust for the payment of the principal of or any premium or interest on the Notes remaining unclaimed
for two years after such principal, premium or interest has become due and payable shall be paid to the Issuer on the Issuer’s
request and all liability of the Paying Agent with respect to such trust money shall thereupon cease.

 

    10

     

    

 

		16.	Changes in Paying Agent or Registrar and Specified Offices

 

		16.1	The Issuer may at any time vary or terminate the appointment of the Paying Agent, Transfer Agent
or the Registrar and appoint additional or other paying agents or registrars.

 

Any variation or termination
shall be made by giving to the Paying Agent, Transfer Agent or Registrar and (if different) to the paying agent, transfer agent
or registrar whose appointment is to be varied or terminated not less than 30 days’ written notice to that effect, which
notice shall expire not less than 30 days before or after any due date for any payment in respect of Notes.

 

		16.2	Subject to clause 16.1, the Paying Agent, Transfer Agent or Registrar may resign its appointment
hereunder at any time by giving to the Issuer not less than 60 days’ written notice to that effect, which notice shall expire
not less than 30 days before or after any due date for any payments in respect of any Notes.

 

		16.3	Notwithstanding clauses 16.1 and 16.2 no such termination of the appointment of, or resignation
by, the Paying Agent, Transfer Agent or Registrar shall take effect until a successor has been appointed on terms approved by the
Issuer or the Issuer has otherwise approved such resignation without a successor being appointed.

 

		16.4	Notwithstanding any other provisions of clause 16.1, the appointment of the Paying Agent, Transfer
Agent or Registrar shall forthwith terminate if at any time such Paying Agent, Transfer Agent or Registrar becomes incapable of
acting, or is adjudged bankrupt or insolvent, or files a voluntary petition in bankruptcy or makes an assignment for the benefit
of its creditors or consents to the appointment of a receiver, administrator or other similar official of it or of all or any substantial
part of its property or admits in writing its inability to pay or meet its debts as they mature or suspends payment thereof, or
if a resolution is passed or an order made for its winding up or dissolution, or if a receiver, administrator or other similar
official of it or of all or any substantial part of its property is appointed, or if any order of any court is entered approving
any petition filed by or against it under the provisions of any applicable bankruptcy or insolvency law, or if any public officer
takes charge or control of such Paying Agent, Transfer Agent or Registrar or its property or affairs for the purpose of rehabilitation,
conservation, administration or liquidation or there occurs any analogous event under any applicable law.

 

		16.5	On the date on which any such termination or resignation takes effect, the Paying Agent, Transfer
Agent or Registrar shall (i) pay to or to the order of its successor (or, if none, the Issuer) any amounts held by it in respect
of the Notes which have become due and payable but which have not been presented for payment; and (ii) deliver to its successor
(or, if none, the Issuer), or as it may direct, all records maintained by it, pursuant hereto. Following such termination or resignation
and pending such payment and delivery, the Paying Agent, Transfer Agent or Registrar shall hold such amounts, records and documents
in trust for and subject to the order of its successor or, as the case may be, the Issuer.

 

		16.6	Any corporation into which any Paying Agent, Transfer Agent or Registrar may be merged or converted
or any corporation with which such Paying Agent, Transfer Agent or Registrar may be consolidated or any corporation resulting from
any merger, conversion or consolidation to which such Paying Agent, Transfer Agent or Registrar shall be a party, or any corporation,
including affiliated corporations, to which the Paying Agent, Transfer Agent or Registrar shall sell or otherwise transfer: (a)
all or substantially all of its assets or (b) all or substantially all of its corporate trust business shall, on the date when
the merger, conversion, consolidation or transfer becomes effective and to the extent permitted by any applicable laws, be the
successor Paying Agent, Transfer Agent or Registrar under this Agreement without any further formality, and after such effective
date all references in this Agreement to such Paying Agent, Transfer Agent or Registrar shall be deemed to be references to such
corporation. Notice of any such merger, conversion, consolidation or transfer shall forthwith be given by the Paying Agent, Transfer
Agent or Registrar to the Issuer and the Trustee.

 

    11

     

    

 

		16.7	The Paying Agent, Transfer Agent or Registrar may change its specified office to another office
in London at any time by giving to the Issuer and the Trustee not less than 60 days’ prior written notice to that effect,
which notice shall expire not less than 30 days before or after any due date for any payments in respect of any Notes, and which
notice shall specify the address of the new specified office and the date upon which such change is to take effect.

 

		17.	Notices

 

		17.1	If the Issuer arranges publication of any notice to the holders of the Notes, it shall at or before
the time of such publication, send copies of each notice so published to the Paying Agent.

 

		17.2	Notwithstanding the above and on behalf of and at the request and expense of the Issuer, the Paying
Agent shall cause to be published all notices required to be given by the Issuer under the Indenture.

 

		17.3	The Paying Agent, Transfer Agent and Registrar shall promptly forward any written notice received
by it from any holders of the Notes to the Issuer and the Trustee.

 

		18.	Communications

 

		18.1	For the purposes of this clause, the address of each party at the date of this Agreement shall
be the address set out below (including, where applicable, the details of the facsimile number, the person for whose attention
the notice or communication is to be addressed and the email address): the Issuer:

 

	AbbVie Inc.	 
	
        1 North Waukegan Road

        North Chicago, Illinois 60064

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: +1 847-598-1431

        Attention: Treasurer

        Email:   tabetha.skarbek@abbvie.com

 

the Paying Agent:

 

	Elavon Financial Services DAC, UK Branch	 
	
        125 Old Broad Street

        London

        EC2N 1AR

        United Kingdom

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: +44 (0)207 365 2577

        Attention: MBS Relationship Management

        Email:    mbs.relationship.management@usbank.com

 

the Transfer Agent:

 

 

    12

     

    

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email:     linda.garcia@usbank.com

 

the Registrar:

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with this
        Agreement.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email: linda.garcia@usbank.com

 

the Trustee:

 

	U.S. Bank National Association	 
	
        Global Corporate Trust Services MK-IL-SLTR

        Attn Corporate Trust Administrator for AbbVie Inc.

        190 S. LaSalle

        Chicago, IL 60603

         

        as may be amended from time to time in accordance with the Indenture
        and notified by the Issuer to the Paying Agent.
	
        Fax: + (1) 312-332-8008

        Attention: Linda Garcia

        Email: linda.garcia@usbank.com

 

    13

     

    

 

		19.	Amendments

 

		19.1	For the avoidance of doubt, this Agreement may be amended in writing by the parties hereto.

 

		19.2	The Issuer shall provide to the Paying Agent a copy of any amendment to the Indenture as soon as
reasonably practicable following such amendment taking effect. Where reference is made in this Agreement to the Indenture, such
reference shall, for the purposes of the Paying Agent’s rights and obligations under this Agreement only, be deemed to refer
to the most recent version of such document provided to the Paying Agent by the Issuer.

 

		20.	Taxes

 

		20.1	The Issuer agrees to pay any and all stamp and other documentary taxes or duties which may be payable
in connection with the execution, delivery, performance and enforcement of this Agreement.

 

		21.	Regulatory Matters

 

		21.1	The Paying Agent is authorised and regulated by the Central Bank of Ireland (“CBOI”)
and its activities in the UK are subject to limited regulation by the UK Prudential Regulation Authority (“PRA”)
and the UK Financial Conduct Authority (“FCA”).

 

		21.2	In connection with the worldwide effort against the funding of terrorism and money laundering activities,
the Paying Agent, Transfer Agent and Registrar may be required under various national laws and regulations to which they are subject
to obtain, verify and record information that identifies each person who opens an account with it. For a non-individual person
such as a business entity, a charity, a Trust or other legal entity the Paying Agent,

 

Transfer Agent and Registrar
shall be entitled to ask for documentation to verify such entity’s formation and legal existence as well as financial statements,
licenses, identification and authorisation documents from individuals claiming authority to represent the entity or other relevant
documentation.

 

		21.3	The parties to this Agreement acknowledge and agree that the obligations of the Paying Agent, Transfer
Agent and Registrar under this Agreement are limited by and subject to compliance by them with EU and US Federal anti-money laundering
statutes and regulations. If the Paying Agent, Transfer Agent and Registrar or any of their directors know or suspect that a payment
is the proceeds of criminal conduct, such person is required to report such information pursuant to the applicable authorities
and such report shall not be treated as a breach by such person of any confidentiality covenant or other restriction imposed on
such person under this Agreement, by law or otherwise on the disclosure of information. The Paying Agent, Transfer Agent and Registrar
shall be indemnified and held harmless by the Issuer from and against all losses suffered by them that may arise as a result of
the agents being prevented from fulfilling their obligations hereunder due to the extent doing so would not be consistent with
applicable statutory anti-money laundering requirements.

 

    14

     

    

 

		21.4	Notwithstanding anything to the contrary in this Agreement or in any other agreement, arrangement
or understanding among any such parties, each party hereto acknowledges that any liability of any party arising under this Agreement
or any such other document, to the extent such liability is unsecured or not otherwise exempted, may be subject to the write-down
and conversion powers of a Resolution Authority and agrees and consents to, and acknowledges and agrees to be bound by:

 

		(a)	the application of any Write-Down and Conversion Powers by a Resolution Authority to any such liabilities
arising hereunder which may be payable to it by any party hereto; and

 

		(b)	the effects of any Bail-in Action on any such liability, including, if applicable:

 

		1.	a reduction in full or in part or cancellation of any such liability;

 

		2.	a conversion of all, or a portion of, such liability into shares or other instruments of ownership
in such party, its parent undertaking, or a bridge institution that may be issued to it or otherwise conferred on it, and that
such shares or other instruments of ownership will be accepted by it in lieu of any rights with respect to any such liability under
this Agreement or any other agreement; or

 

		3.	the variation of the terms of such liability in connection with the exercise of the Write-Down
and Conversion Powers of any Resolution Authority.

 

For the purpose of this sub-clause 21.4
the following terms shall have the following meanings:

 

“Bail-In Action” means
the exercise of any Write-Down and Conversion Powers by the applicable Resolution Authority.

 

“Bail-In Legislation”
means, with respect to any EEA Member Country implementing Article 55 of Directive 2014/59/EU of the European Parliament and of
the Council of the European Union, the implementing law for such EEA Member Country from time to time which is described in the
EU Bail-In Legislation Schedule and in relation to any other state, any analogous law or regulation from time to time which requires
contractual recognition of any Write-down and Conversion Powers contained in that law or regulation.

 

“EEA Member Country”
means any of the member states of the European Union, Iceland, Liechtenstein, and Norway.

 

“EU Bail-In Legislation Schedule”
means the EU Bail-In Legislation Schedule published by the Loan Market Association (or any successor person), as in effect from
time to time.

 

“Resolution Authority”
means any public administrative authority or any person entrusted with public administrative authority to exercise any Write-down
and Conversion Powers.

 

“Write-Down and Conversion Powers”
means,

 

		(a)	in relation to any Bail-In Legislation described in the EU Bail-In Legislation Schedule from time
to time, the powers described as such in relation to that Bail-In Legislation in the EU Bail-In Legislation Schedule; and

 

		(b)	any powers under the Bail-In Legislation to cancel, transfer or dilute shares issued by a person
that is a bank or investment firm or other financial institution or affiliate of a bank, investment firm or other financial institution,
to cancel, reduce, modify or change the form of a liability of such a person or any contract or instrument under which that liability
arises, to convert all or part of that liability into shares, securities or obligations of that person or any other person, to
provide that any such contract or instrument is to have effect as if a right had been exercised under it or to suspend any obligation
in respect of that liability or any of the powers under that Bail-In Legislation that are related to or ancillary to any of those
powers; and any similar or analogous powers under that Bail-In Legislation.

 

    15

     

    

 

		22.	Governing Law and Jurisdiction

 

		22.1	This Agreement shall be construed and enforced in accordance with, and the rights of the parties
shall be governed by, the law of the State of New York.

 

		22.2	Each of the Paying Agent, the Transfer Agent, the Registrar and the Issuer irrevocably submits
to the non-exclusive jurisdiction of any New York State or federal court sitting in the Borough of Manhattan, The City of New York,
over any suit, action or proceeding arising out of or relating to this Agreement. To the fullest extent permitted by applicable
law, each of the Paying Agent , the Transfer Agent, the Registrar and the Issuer irrevocably waives and agrees not to assert, by
way of motion, as a defense or otherwise, any claim that it is not subject to the jurisdiction of any such court, any objection
that it may now or hereafter have to the laying of the venue of any such suit, action or proceeding brought in any such court and
any claim that any such suit, action or proceeding brought in any such court has been brought in an inconvenient forum.

 

		22.3	Each of the Paying Agent, the Transfer Agent, the Registrar and the Issuer agrees, to the fullest
extent permitted by applicable law, that a final judgment in any suit, action or proceeding of the nature referred to in clause
22.2 brought in any such court shall be conclusive and binding upon it subject to rights of appeal, as the case may be, and may
be enforced in the courts of the United States of America or the State of New York (or any other courts to the jurisdiction of
which it or any of its assets is or may be subject) by a suit upon such judgment.

 

		22.4	THE PARTIES HERETO HEREBY WAIVE TRIAL BY JURY IN ANY ACTION BROUGHT ON OR WITH RESPECT TO THIS
AGREEMENT.

 

		23.	COUNTERPARTS

 

This Agreement may be executed
in any number of counterparts and the signatories of all parties need not appear on the same counterpart. Each counterpart, when
executed and delivered, shall be an original, but all of which when taken together shall constitute a single instrument. The delivery
of signed counterparts by facsimile or email transmission that includes a copy of the sending party’s signature is as effective
as signing and delivering the counterpart in person.

 

    16

     

    

 

AS WITNESS the hands of the parties
or their duly authorised agents the day and year first above written.

 

	ABBVIE INC., AS ISSUER
	 
	By:	 /s/ Tabetha A. Skarbek	 
	Name:	 Tabetha A. Skarbek	 
	Title:	 Vice President and Treasurer	 
	 	 
	 	 
	ELAVON FINANCIAL SERVICES DAC, U.K. BRANCH, AS PAYING AGENT
	 
	By:	 /s/ David Harnett	 
	Name:	David Harnett	 
	Title:	 Authorised Signatory	 
	 	 
	By:	 /s/ Michael Leong	 
	Name:	Michael Leong	 
	Title:	 Authorised Signatory	 
	 	 
	 	 
	U.S. BANK NATIONAL ASSOCIATION, AS TRANSFER AGENT AND REGISTRAR
	 
	By:	/s/ Linda E. Garcia	 
	Name:	 Linda E. Garcia	 
	Title:	Vice President	 
	 	 	 
	 	 
	U.S. BANK NATIONAL ASSOCIATION, AS TRUSTEE
	 
	By:	 /s/ Linda E. Garcia	 
	Name:	 Linda E. Garcia	 
	Title:	Vice President	 

 

    

     

    

 

APPENDIX
1

 

Indenture

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00300-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00300-of-00352.parquet"}]]