Document:

EXHIBIT 4.6

                             FORM OF PROMISSORY NOTE

                              Due: _________, 2002

$_______________                                                __________, 2002

           FOR VALUE RECEIVED, MERA PHARMACEUTICALS, INC., a Delaware
corporation (the "Company"), hereby promises to pay to the order of
______________, a Delaware limited liability company (the "Investor"), at the
place designated by the Investor, the principal amount of
_________________________________________ ($____________) in lawful money of the
United States of America, and to pay interest in like money in the amount and on
the terms set forth in Section 1 hereof.

1. PAYMENTS OF INTEREST AND PRINCIPAL. Payments of principal plus interest on
the unpaid principal balance hereof outstanding from time to time shall be
payable in accordance with the following:

     a)   The outstanding principal balance on this Note shall be due and
          payable to the Investor by the Company in full on ________________,
          2002 (the "Maturity Date").

     b)   From and after the date hereof, interest on the outstanding principal
          balance shall accrue at the rate of 6% per annum and be due and
          payable to the Investor on the Maturity Date.

     c)   Interest shall accrue and be payable until this Note is paid in full
          pursuant to the terms of this Note. All payments of principal,
          interest, fees and other amounts due hereunder shall be made by the
          Company in lawful money of the United States of America, by wire
          transfer or by any other method approved in advance by the Investor at
          the office of the Investor set forth in Section 6 hereof or at such
          other place designated by the Investor in writing to the Company in
          immediately available and freely transferable funds at such place of
          payment.

2. PREPAYMENT. This Note may be prepaid, in whole or in part at any time without
the prior written consent of the Investor and without premium or penalty, at the
election of the Company.

3. DEFAULT. Repayment of all principal and interest under this Note will be
accelerated and shall be immediately due in full at the election of the Investor
in the event of any of the following (each an "Event of Default"):

     a)   failure to pay any interest or principal due on this Note when and as
          the same shall become due and payable, either at maturity or by
          acceleration or otherwise;

     b)   the Company shall (i) apply for or consent to the appointment of a
          receiver, trustee or liquidator of the Company or any of its property,
          (ii) admit in writing its general inability to pay its debts as they
          mature, (iii) make a general assignment for the benefit of creditors,
          (iv) commence a voluntary case under the federal bankruptcy laws or
          file a petition or answer seeking reorganization or an arrangement
          with creditors to take advantage of any other bankruptcy,
          reorganization, insolvency, readjustment of debt, dissolution or
          liquidation law or statute, or file an answer admitting the material
          allegations of a petition filed against it in any proceeding under any
          such law, or (v) take corporate action for the purpose of effecting
          any of the foregoing; or an order, judgment or decree shall be
          entered, without the application, approval or consent of the Company,
          by any court of competent jurisdiction, approving a petition seeking
          reorganization of the Company or of all or a substantial part of the
          assets of the Company and such order, judgment or decree shall
          continue unstayed and in effect for a period of thirty (30) days;

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     c)   failure to observe and perform any of the terms, covenants,
          conditions, or agreements required to be observed and performed by the
          Company under this Note, and such failure shall remain unremedied for
          thirty (30) days after notice shall have been provided to the Company
          by the Investor of such default or for such longer period as shall be
          necessary if such default is not capable of being remedied within such
          thirty-day period and the Company is diligently proceeding to cure
          such default.

4. RIGHTS AND REMEDIES. Upon the occurrence of an Event of Default and at any
time thereafter, the holder hereof shall have the rights and remedies provided
herein and under applicable law.

5. GOVERNING LAW. This Note shall be governed by and construed in accordance
with the domestic substantive laws of the State of California, without giving
effect to any choice or conflict of law provision or rule that would cause the
application of the laws of any other jurisdiction.

6. NOTICES. All notices and other communications given to any party hereto
pursuant to this Agreement shall be in writing and shall be hand delivered, or
sent either by (a) certified mail, postage prepaid, return receipt requested;
(b) a nationally reputable overnight express courier service that provides
written confirmation of delivery; or (c) facsimile transmission with written
confirmation by the sending machine or with telephone confirmation of receipt
(provided that a confirming copy is sent by a nationally reputable overnight
express courier service that provides written confirmation of delivery),
addressed as follows:

(a) If to the Company, to:

                    Mera Pharmaceuticals, Inc.
                    777 South Highway 101, Suite 215
                    Solana Beach, CA  92075
                    Fax #: 858-847-9090
                    Attention: Daniel P. Beharry

(b) If to the Investor, to:

Any communication given in conformity with this Section shall be effective upon
the earlier of actual receipt or deemed delivery. Delivery shall be deemed to
have occurred as follows: if hand delivered on the day so delivered; if mailed,
three business days after the same is deposited in the United States Mail; if
telecopied, upon written confirmation by the sending machine of effective
transmission or upon telephone confirmation of receipt; and if sent by overnight
express courier service, the next business day. Any party may at any time change
its address for receiving communications pursuant to this Section by giving
notice of a new address in the manner provided herein.

7. COMPANY'S WAIVERS. The Company, to the extent permitted by law, waives and
agrees not to assert or take advantage of any of the following: (a) any defense
based upon an election of remedies by the Investor which may destroy or
otherwise impair any subrogation or other rights of the Company or any partner
in the Company or any guarantor or endorser of this Note; (b) any duty on the
part of the Investor to disclose any facts or other data the Investor may now or
hereafter know; (c) acceptance or notice of acceptance of this Note by the
Company; (d) presentment and/or demand for payment of this Note or any
indebtedness or obligations hereby promised; and (e) protest and notice of
dishonor and acceleration with respect to this Note or any indebtedness or
performance of obligations arising hereunder.

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8. NO WAIVER OF RIGHTS. No failure on the part of the Investor in exercising any
right or remedy hereunder shall operate as a waiver thereof, nor shall any
single or partial exercise of any such right or remedy preclude any other or
future exercise thereof or the exercise of any other right or remedy hereunder.
No modification or waiver of any provision of this Note, nor any departure by
the Company therefrom, shall in any event be effective unless the same shall be
in writing, in accordance with this Note, and then such waiver or consent shall
be effective only in the specific instance and for the specific purpose given.

9. ASSIGNMENT. This Note may be transferred or assigned in whole or in part
without the consent of the Company by the Investor or a subsequent holder
hereof. The Investor or such holder hereof shall notify the Company of such
assignment forthwith upon the completion thereof and such assignment shall not
be effective insofar as the Company is concerned until it shall have been
notified thereof. The Company shall maintain a record of all such assignments.

10. TRANSFER. Upon the transfer or assignment of this Note, the holder hereof
may cause a new Note to be made and delivered by the Company, at the expense of
the Company, upon surrender of this Note, which new Note shall be payable to
such person, or persons, or order, as may be designated by such holder.

11. HEADINGS. The headings of the sections of this Note are inserted for
convenience only and do not constitute a part of this Note.

12. SERVICE OF PROCESS; CONSENT TO JURISDICTION. The Company hereby irrevocably
appoints each and every one of its officers as its attorney upon whom may be
served any notice, process or pleading in any action or proceeding against it
arising out of or in connection with this Note or any document executed or
action taken in connection therewith; and the Company hereby consents that any
action or proceeding against it be commenced and maintained in San Diego County,
California or in the United States District Court for the Southern District of
California by service of process on any such officer; and the Company agrees
that such courts shall have jurisdiction with respect to the subject matter
hereof and the Company.

IN WITNESS WHEREOF, Mera Pharmaceuticals, Inc. has caused this Note to be signed
and to be dated the day and year first above written.

                                           MERA PHARMACEUTICALS, INC.

                                           By: _________________________________
                                               Name:   Daniel P. Beharry
                                               Title:      Secretary

<PAGE>EXHIBIT 10.8

                                    SUBLEASE

This sublease (the "Sublease") is entered into as of this 1st day of August by
and between Ancile Pharmaceuticals, Inc. ("Ancile") and Mera Pharmaceuticals,
Inc. ("Mera").

WHEREAS, Ancile is a subtenant of certain office and laboratory space located at
9381 Judicial Drive, San Diego, CA (the "Premises"), which is more completely
and specifically described in the sublease dated April 10, 2002 between Ancile
and Triad Therapeutics, Inc. ("Triad"), a copy of which is attached hereto as
APPENDIX A (together with the Operating Services Agreement between Ancile and
Triad dated April 10, 2002, the "Triad Sublease"); and

WHEREAS, Triad is the prime tenant of the Premises (plus additional space at the
same location) under a lease between Triad and University Center East, LLC (the
"Prime Lease"), a copy of which is attached hereto as APPENDIX B;

WHEREAS, Ancile wishes to sublet to Mera, and Mera wishes to sublet from Ancile,
a portion of the Premises, which is shown on the floor plan attached hereto as
APPENDIX C (the "Mera Premises") on the terms and conditions set forth in this
Sublease;

NOW, THEREFORE, Ancile and Mera agree as follows:

     1.   SUBLEASE. Ancile hereby sublets to Mera and Mera hereby sublets from
          Ancile the Mera Premises, consisting of approximately 3414 square
          feet, 1860 square feet of which is laboratory, 1045 square feet of
          which is the Initial Office Area and 509 square feet of which
          constitutes a pro rata portion of common areas and shared space. Mera
          may restrict access by Ancile to any portion of the Mera Premises that
          is not designated shared space on APPENDIX C (the "Mera Space") to
          Mera personnel only, and Ancile may restrict access to any portion of
          the Premises that is not the Mera Premises (the "Ancile Space") to
          Ancile personnel only, in each case the use of connecting corridors or
          passageways to move between the Mera Space and shared space on the one
          hand and the Ancile Space and shared space on the other is not to be
          restricted at any time. The use of the main ground floor conference
          room shall be on a reservation basis. Ancile and Mera shall cooperate
          to resolve any scheduling conflicts for the conference room.

     2.   MOVE TO THE LONG-TERM OFFICE SPACE. Mera may, upon not less than 30
          days prior notice, elect to move from the Initial Office Area into the
          Long-Term Office Area, or on such lesser notice, as Ancile may accept.
          Upon the move into the Long-Term Office Area, the total area of the
          Mera premises shall be increased to 4977 square feet, and the rent
          payable under paragraph 3, below, shall be adjusted accordingly. Each
          party shall bear its own expenses associated with Mera's move from the
          Initial Office Area into the Long-Term Office Area.

     3.   RENT. Subject to the adjustment provide for in paragraph 2, above,
          Mera shall pay to Ancile rent equal to $3.00 per square foot, or a
          monthly rent of $10,578, NNN. The rent shall increase by 3.5% (to
          $3.105 per square foot) on June 1, 2003, and by an additional 3.5%
          each year thereafter, for as long as Mera continues to occupy the Mera
          Premises. Rent shall be due and payable in advance on the first day of
          each month during the term of this Sublease.

     4.   OPERATING EXPENSES AND UTILITIES. In addition to the rent, Mera shall
          be responsible for the per square foot charges for operating expenses
          and utilities, as assessed against Ancile under the Triad sublease,
          pursuant to the Operating Services Agreement attached as part of
          APPENDIX A. Any separate additional charges incurred by either Ancile
          or Mera shall be the responsibility of that party alone.

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     5.   USE OF THE MERA PREMISES. Mera shall be entitled to use the Mera
          Premise for the purposes set forth in the Triad Sublease and for no
          other purpose.

     6.   TERM. The term of this Sublease shall commence on June 1, 2002 and
          continue for a period of not less than twelve (12) months thereafter.
          Mera shall have the right to continue occupying the Mera Premises
          month-to-month commencing June 1, 2003 provided Ancile continues to
          occupy the Premises under the Triad Sublease. After May 31, 2003, Mera
          shall have the right to give Ancile not less than 60 days notice of
          Mera's intention to terminate the Sublease and vacate the Mera
          Premises. Beginning March 31, 2004, Ancile shall have the right to
          terminate the Sublease with not less than 60 days notice to Mera.
          [Note: this provides Mera with 2 years total guaranteed occupancy, if
          so desired.]

     7.   NOTIFICATION OF INTENT TO TERMINATE. In the event Ancile elects to
          terminate the Triad Sublease for any reason, Ancile will provide Mera
          with written notice of its intent to terminate no later than 60 days
          prior to termination of the Triad Sublease.

     8.   SECURITY DEPOSIT. Upon its occupancy of the Mera Premises, Mera will
          deliver to Ancile a refundable security deposit of $30,000, to be held
          in a trust account identifying Mera as the beneficiary. So much of the
          security deposit as is needed shall be credited toward the payment by
          Mera of the last month of rent due from it under this Sublease. The
          remainder shall be held as security for the repair of any damages
          caused by Mera to the Premises during its occupancy of the Mera
          Premises under this Sublease, and it shall be refunded to Mera on the
          same terms as Ancile is entitled to receive a refund of its security
          deposit under the Triad Sublease. In the event that the Triad Sublease
          terminates prior to May 31, 2003 for any reason, Ancile shall return
          the entire security deposit then remaining to Mera upon the effective
          date of termination, less any amount necessary to restore the Mera
          Premises to suitable condition.

     9.   SIGNAGE. Mera shall be entitled to affix a sign at the entrance to the
          Premises indicating its occupancy of the Mera Premises, subject to any
          consents required under the Triad Sublease. Such sign shall be of a
          size and in a style that complies with the requirements and
          limitations therefor applicable under the Triad Sublease.

     10.  SUBLETTING. Mera may not assign this Sublease or further sublet all or
          any part of the Mera Premises without the prior written consent of
          Ancile and, if required under the Triad Sublease, the prior written
          consent of Triad and Master Landlord (as defined in the Triad
          Sublease).

     11.  APPLICABILITY OF TRIAD SUBLEASE. All of the terms and provisions of
          the Triad Sublease are incorporated into and made a part of this
          Sublease, with Ancile substituted for Triad in the Triad Sublease, and
          Mera substituted for Ancile in the Triad Sublease. Notwithstanding the
          foregoing, in the event of any conflict between the terms of this
          Sublease and the terms of the Triad Sublease, then as between Ancile
          and Mera, the terms of this Sublease shall control.

     12.  AGENCY DISCLOSURE. Ancile and Mera each warrants that it has not dealt
          with any real estate broker or agent in connection with this Sublease
          and that none of them is obligated to pay any commission to any third
          party by virtue of this transaction.

<PAGE>

     13.  INDEMNIFICATION. Mera and Ancile each shall hold the other harmless
          from any loss, cost, damage, claim or liability resulting from their
          respective use of the Premises.

     14.  INSURANCE. Mera shall be responsible for compliance with the insurance
          provisions of the Triad Sublease. Mera shall name Ancile, Triad and
          Master Landlord (as such term is defined in the Triad Sublease) as
          additional insureds on such policy(ies).

     15.  NOTICES. All notices required or permitted to be given to any party
          under this Sublease shall be in writing, and shall be delivered either
          by hand delivery, facsimile, overnight delivery service or via First
          Class U.S. Mail, postage prepaid, to the addresses set forth below or
          to such other address as any party may, in writing, specify by notice
          to the other parties:

                     If to Ancile:
                     Ancile Pharmaceuticals, Inc.
                     9381 Judicial Drive, Suite 160
                     San Diego, CA  92121
                     Attn:     Chief Executive Officer
                     Facsimile:858 677 2180

                     If to Mera:
                     777 South Highway 101, Suite 215
                     Solana Beach, CA  92075
                     Attn:     Richard D. Propper, MD
                     Facsimile:858 847 9090

ANCILE PHARMACEUTICALS, INC.              MERA PHARMACEUTICALS, INC.

By:                                      By:
      ------------------------------           ------------------------------

Name:                                    Name:
      ------------------------------           ------------------------------

Its:                                     Its:
      ------------------------------           ------------------------------

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