Document:

EX-10.5

 Exhibit 10.5 

CONFIDENTIAL 

EXECUTION VERSION 

Amended and Restated 

mRNA Cancer Vaccine Collaboration and License Agreement 

by and between 

MODERNATX, INC. 

and 

MERCK SHARP & DOHME CORP. 

April 17, 2018 

 List of Exhibits and Schedules 

Exhibit A-1: POC Plan for PCV Program 

Exhibit A-2: POC Plan for KRAS Program 

Exhibit A-3: Research Plan for [***] 

Exhibit B: Financial Definitions 
 Exhibit C: Relative Commercial
Value 
 Exhibit D: Exercise of Merck Participation Election – Profit & Loss Share 

Exhibit E: Economic Effects of Merck Non-Participation and Merck Cessation of Collaboration Activities

 Exhibit F: In-Licenses 

Exhibit G: Confidential CMC Document Review Procedures 
 Exhibit
H: Moderna Technology Transfer 
 Exhibit I: Form Press Release 

Exhibit J: Patent Prosecution and Maintenance; Patent Enforcement 

Exhibit K: Supply Terms 
 Exhibit L: Subcontractors and
Sublicensing 
 Exhibit L-1: Permitted Subcontractors 

Exhibit L-2: Certain Sublicensing/Subcontracting Examples 

Exhibit M: Terms for PCV Clinical Supply Agreement and SAV Clinical Supply Agreement 

Exhibit N: Supply Terms for Merck Internal SAV Programs 

Schedule 1.235: Moderna Background Patents 

Schedule 1.253: Moderna Pre-Existing In-Licenses 

Schedule 3.4(c)(ii): Initial KRAS Transition Plan 
 Schedule
6.1(d)(iv): Required Manufacturing Items 

 AMENDED AND RESTATED MRNA CANCER VACCINE COLLABORATION AND LICENSE AGREEMENT 

This Amended and Restated mRNA Cancer Vaccine Collaboration and License Agreement (this “Agreement”), dated
as of April 17, 2018 (the “Amended Effective Date”), is made by and between ModernaTX, Inc., a corporation organized and existing under the laws of Delaware (“Moderna”), and Merck Sharp & Dohme
Corp., a corporation organized and existing under the laws of New Jersey (“Merck”). Each of Moderna and Merck may be referred to herein as a “Party” or together as the “Parties”. 

WHEREAS, Moderna and its Affiliates have developed expertise and technology useful for the research, development, manufacture,
or commercialization of pharmaceutical products that function using mRNA; 
 WHEREAS, Moderna and its Affiliates are focused
on the advancement of mRNA cancer vaccines that are based on formulated mRNA Constructs that encode for neoantigens or other antigens using mRNA Technology; 

WHEREAS, Merck is a pharmaceutical company focused on researching, developing, manufacturing and commercializing innovative
therapeutic products; 
 WHEREAS, Merck and Moderna previously entered into that certain PCV Collaboration and License
Agreement dated as of June 28, 2016, as amended (the “Original Agreement” and such date, the “Effective Date”) pursuant to which the Parties established a broad research and development collaboration pursuant
to which Moderna would Research and Develop Collaboration PCV Products through proof of concept, and Merck would thereafter have the right to continue with Moderna in the Research, Development, Manufacture and Commercialization of Collaboration PCV
Products; and 
 WHEREAS, the Parties now desire to amend and restate the Original Agreement in its entirety and replace the
Original Agreement with this Agreement, to, among other things, expand the scope of the Collaboration to include SAVs in addition to PCVs. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the
amount and sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 
  

	1.	 DEFINITIONS 

The following terms and their correlatives will have the following meanings: 

1.1 “2015 Collaboration Agreement” means that certain Master Collaboration and License Agreement, by and
between Moderna and Merck, dated as of January 12, 2015, as amended or restated from time to time. 
 1.2 “2016
CSA” means that certain Pre-Clinical and Clinical Supply Agreement, by and between Moderna and Merck, dated on or about June 27, 2016, as amended or restated from time to time. 

  
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 1.3 “AAA” has the meaning set forth in Section 15.1(c).

 1.4 “Act” means, as applicable, the United States Federal Food, Drug and Cosmetic Act, 21 U.S.C.
§§ 301 et seq., and/or the Public Health Service Act, 42 U.S.C. §§ 262 et seq., as such may be amended from time to time, together with any rules, regulations and requirements promulgated thereunder (including all additions,
supplements, extensions, and modifications thereto). 
 1.5 “Additional Converted Program Research
Activities” has the meaning set forth in Section 3.1(e)(i)(1). 
 1.6 “Additional Moderna PCV POC Term
Study” has the meaning set forth in Section 3.3(d). 
 1.7 “Additional Research Plan” means a
written plan setting forth the Collaboration Activities of the Parties with respect to any Additional Research Program and the budget therefor that is approved by both of the Parties. 

1.8 “Additional Research Program” has the meaning set forth in Section 4.1(b). 

1.9 “Additional Regulatory Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.10 “Additional Study” means any Clinical Study (including any Phase IV Clinical Study) proposed by a Party
pursuant to Section 4.4(a)(i) to be conducted during the Merck Participation Term for a given Program to Develop any Collaboration Product from such Program as a monotherapy or in combination with one or more Other Components beyond any
Clinical Study(ies) contemplated by the then-current Joint Development Plan and Budget for the applicable Program. 
 1.11
“Additional Study Proposal” has the meaning set forth in Section 4.4(a)(i). 
 1.12 “Adverse
Event” per the International Conference on Harmonization (ICH), means any untoward medical occurrence in a patient or clinical investigation subject administered a pharmaceutical product and which does not necessarily have to have a causal
relationship with this treatment. An Adverse Event can therefore be any unfavorable and unintended sign (including an abnormal laboratory finding, for example), symptom, or disease temporally associated with the use of a medicinal product, whether
or not considered related to such medicinal product. 
 1.13 “Affiliate” of a Person means any other Person
which (directly or indirectly) is controlled by, controls or is under common control with such Person. A Person will be deemed to “control” another Person if it: (a) with respect to such other Person that is a corporation, owns,
directly or indirectly, beneficially or legally, more than fifty percent (50%) of the outstanding voting securities or capital stock (or such lesser percentage which is the maximum allowed to be owned by such Person in a particular jurisdiction) of
such other Person, or, with respect to such other Person that is not a corporation, has other comparable ownership interest; or (b) has the power, whether pursuant to contract, ownership of securities or otherwise, to direct the management and
policies of such other Person. 

  
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 1.14 “Agent Technology” means the Moderna Agent Technology and
the Merck Agent Technology. 
 1.15 “Agreement” has the meaning set forth in the Recitals. 

1.16 “Allowable Commercialization Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.17 “Allowable Development Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.18 “Amended Anticipated PCV POC Budget” means Two Hundred Forty-Three Million Dollars ($243,000,000), or
such other amount as the Parties may mutually agree in the POC Plan for the PCV Program. 
 1.19 “Amended Effective
Date” has the meaning set forth in the Recitals. 
 1.20 “Antitrust Clearance Date” has the meaning
set forth in Section 14.1. 
 1.21 [***] 

1.22 “Bankruptcy Code” has the meaning set forth in Section 10.5. 

1.23 “Batch Records” means, with respect to a batch of product Manufactured, (a) batch records (including
all attachments thereto), including pre-filtration Bioburden results, per process environmental monitoring reports, differential pressure alarm reports, CIP/SIP data,
in-process CTU temperature charts, reports and details of major investigations, and reports and details of product related change controls, in English, and (b) any investigation or deviation reports (and
details thereof) related to such product, in English, and (c) a release assay qualification summary report and a pre-campaign cleaning report, in English; in each case, for such batch. 

1.24 “Business Combination” means, with respect to a Party (or its Affiliate), any of the following events:
(a) any Third Party (or group of Third Parties acting in concert) acquires (including by way of a tender or exchange offer or issuance by such Party (or its Affiliate)), directly or indirectly, beneficial ownership or a right to acquire
beneficial ownership of shares of such Party (or its Affiliate) representing more than fifty percent (50%) of the voting shares (where voting refers to being entitled to vote for the election of directors) then outstanding of such Party (or its
Affiliate); (b) such Party (or its Affiliate) consolidates with or merges into another corporation or entity which is a Third Party, or any corporation or entity which is a Third Party consolidates with or merges into such Party (or its
Affiliate), in either event, pursuant to a transaction in which more than fifty percent (50%) of the voting shares of the acquiring or resulting entity outstanding immediately after such consolidation or merger is not held by the holders of the
outstanding voting shares of such Party (or its Affiliate) immediately preceding such consolidation or merger; or (c) such Party (or its Affiliate) sells, transfers, leases or otherwise disposes of all or substantially all of the assets to
which this Agreement relates to a Third Party. 

  
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 1.25 “Business Day” means any day other than a Saturday or
Sunday on which banking institutions in New York, NY are open for business. 
 1.26 “Calendar Quarter” means
the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30 and December 31; provided, however, that (a) the first Calendar Quarter of this Agreement shall commence on the
Effective Date and end at the end of the Calendar Quarter in which the Effective Date occurs and (b) the last Calendar Quarter of this Agreement shall commence at the commencement of such Calendar Quarter and end on the expiration of the Term.

 1.27 “Calendar Year” means each twelve (12) month period beginning on January 1st; provided,
however, that (a) the first Calendar Year of this Agreement shall commence on the Effective Date and end on December 31 of the same year and (b) the last Calendar Year of this Agreement shall commence on January 1 of the Calendar
Year in which this Agreement expires and end on the expiration of the Term. 
 1.28 “Cash Losses” has the
meaning set forth in the Financial Definitions Exhibit. 
 1.29 “Cash Profits” has the meaning set forth in
the Financial Definitions Exhibit. 
 1.30 “Cash Profits or Losses” has the meaning set forth in the
Financial Definitions Exhibit. 
 1.31 [***] 

1.32 “Cessation Transition Plan” has the meaning set forth in Section 10.10(b). 

1.33 “cGMP” means the then-current good manufacturing practices, standards, guidelines and regulations
promulgated and published by FDA, EMA or any other applicable Regulatory Authorities having jurisdiction over the Manufacture, Development or Commercialization of any product (and any precursor steps), as applicable, relating to the testing,
manufacturing, processing, packaging, holding or distribution of drug substances and finished drugs including any standards, guidelines and regulations as promulgated by, as applicable: (a) the FDA under and in accordance with the U.S. Federal
Food, Drug and Cosmetic Act and Title 21, Parts 210 and 211 of the U.S. Code of Federal Regulations, (b) the EMA and the EU Commission under European Directive 2003/94/EC, and/or (c) the ICH Harmonised Tripartite Good Manufacturing
Practice Guide For Active Pharmaceutical Ingredients (ICH Q7), as such standards, guidelines and regulations may be amended from time to time. 

1.34 “Clinical Data” means all information with respect to a Collaboration Product made, collected or
otherwise generated under or in connection with Clinical Studies for such Collaboration Product undertaken under the applicable POC Plan or Development Plan(s), including any data, reports and results with respect thereto. 

  
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 1.35 “Clinical Initiation Criteria” means, with respect to a
given Joint SAV Program (other than the KRAS Program), the criteria that are agreed upon by the Parties as part of, and set forth in, the POC Plan for such Joint SAV Program, which may be changed from time to time by written agreement of the Parties
and which, among other data and information, will be used by the Parties to determine the suitability of an SAV for (a) the filing of an IND for such SAV and (b) the conduct of Phase I Clinical Studies with such SAV under such Joint SAV
Program. The Clinical Initiation Criteria shall include criteria based upon [***]. 
 1.36 “Clinical Quality
Agreement” means a quality agreement entered into between the Parties with respect to the Manufacture of Collaboration Product for Development purposes during the Collaboration Term for the applicable Program, including pursuant to
Section 6.2(d), 6.2(e) or Exhibit K. 
 1.37 “Clinical Study” means a
clinical study (including a Post-Marketing Study or Phase IV Clinical Study) in humans the purpose of which is to obtain information regarding the product, including information relating to the safety, tolerability, pharmacological activity,
pharmacokinetics, dose ranging or efficacy of the product, as applicable. 
 1.38 [***] 

1.39 “CMC” means Chemistry and Manufacturing Controls, which includes (a) Manufacturing process
development records for products, (b) all chemistry, Manufacturing and control procedures necessary for Manufacture of products, and (c) sourcing and testing of all raw materials and components used in the Manufacture of products. 

1.40 “Co-Promotion” means those detailing and promotional activities
(including performing sales calls) with respect to a Collaboration Product undertaken by or on behalf of either Party to encourage appropriate prescribing of such Collaboration Product in the U.S. in accordance with Section 8 and any Co-Promotion Agreement. When used as a verb, “to Co-Promote” means to engage in Co-Promotion, and “Co-Promoted” has a corresponding meaning. 
 1.41 “Co-Promotion Agreement” has the meaning set forth in Section 8.5(b). 
 1.42
“Code” has the meaning set forth in Section 5.4. 
 1.43 “Collaboration” means each of
the programs for the Research, Development, Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) that is engaged in by or on behalf of one or more of the Parties under this Agreement during the applicable
Collaboration Term. 
 1.44 “Collaboration Activities” means the activities conducted by or on behalf of one
or more of the Parties or its Affiliates as part of the Collaboration. 
 1.45 [***] 

1.46 “Collaboration Know-How” means [***]. 

1.47 [***] 

  
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 1.48 [***] 

1.49 [***] 

1.50 “Collaboration Patents” means any and all Patents that claim or cover any of the Collaboration Know-How. 
 1.51 “Collaboration PCV Manufacturing Facility” means, with
respect to the PCV Program, the Manufacturing facilities, or portion thereof, established by or on behalf of Moderna [***] for the PCV Program that is intended to be used for the Manufacture of Collaboration PCV Products for the PCV Program during
the Collaboration Term for the PCV Program in accordance with this Agreement. 
 1.52 “Collaboration PCV
Product” means, with respect to the PCV Program, any [***]. At either Party’s request, the Parties will mutually identify the then-existing Collaboration PCV Products. [***] For the avoidance of doubt, Collaboration PCV Products shall
exclude Collaboration SAV Products; provided, however, that a Collaboration PCV Product for [***]. 
 1.53
“Collaboration Product” means any Collaboration PCV Product or Collaboration SAV Product, as applicable. 

1.54 “Collaboration SAV Manufacturing Facility” means, with respect to a given Joint SAV Program, the
Manufacturing facilities, or portion thereof, that are intended to be used for the Manufacture of Collaboration SAV Products for such Joint SAV Program during the Collaboration Term for such Joint SAV Program in accordance with this Agreement. 

1.55 “Collaboration SAV Product” means, with respect to a given Joint SAV Program, any [***]. For the
avoidance of doubt, Collaboration SAV Products shall exclude Collaboration PCV Products. 
 1.56 “Collaboration
Shared Neoepitope(s)” means, with respect to a given SAV Program, [***]. 
 1.57 “Collaboration
Technology” means, [***]. 
 1.58 “Collaboration Term” means, with respect to a given Program, the
Internal SAV Program Term (if any), the POC Term, the Merck Participation Election Period, and, if Merck exercises the Merck Participation Election, the Merck Participation Term, in each case for such Program. 

1.59 “Combination Product” means: 

(a) a single pharmaceutical formulation [***] containing, as its active ingredients, both (i) a Collaboration Product or
Financial PCV or Financial SAV, on the one hand, and (ii) one or more Other Component(s), on the other hand, or 

  
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 (b) a combination therapy comprised of (i) a Collaboration Product or
Financial PCV or Financial SAV, on one hand, and (ii) one or more Other Component(s), on the other hand, either when (1) priced and sold in a single package containing such multiple products, or (2) packaged separately but sold
together for a single price,  
 in each case, including all dosage forms,
formulations, presentations, and package configurations. Drug delivery vehicles, adjuvants and excipients will not be deemed to be “active ingredients”, except in the case where such delivery vehicle, adjuvant or excipient is recognized by
the FDA as an active ingredient in accordance with 21 C.F.R. 210.3(b)(7). 
 1.60 “Commencement” means,
together with all correlative meanings, [***] in a Clinical Study. 
 1.61 [***] 

1.62 “Commercial Grant” means a grant by a Selling Party of a license or sublicense of the Merck Technology or
Moderna Technology to a Third Party to Commercialize (which may also include Manufacture and Development to support any such Commercialization) any one or more Collaboration Products or Financial PCVs or Financial SAVs within one or more countries.

 1.63 “Commercial Liabilities” has the meaning set forth in the Financial Definitions Exhibit. 

1.64 “Commercial Quality Agreement” has the meaning set forth in Section 6.3(b). 

1.65 “Commercial Supply Agreement” has the meaning set forth in Section 6.3(b). 

1.66 “Commercialization” means any and all activities related to the import, export, transportation, storage,
marketing, detailing, promotion, distribution, sale or other disposition and/or other approved use of a product in a country or region in the Territory, including: (a) strategic marketing, sales force detailing (including Co-Promotion), advertising, Medical Affairs, reimbursement and market access activities and market and product support; and (b) all customer support, Distribution Matters, invoicing and sales activities. When
used as a verb, “to Commercialize” and “Commercializing” means to engage in Commercialization, and “Commercialized” has a corresponding meaning. For clarity, Commercialization excludes any Research, Development or
Manufacturing activities. 
 1.67 “Commercialization Activities” means, on a Collaboration Product-by-Collaboration Product basis, all global Commercialization activities undertaken with respect to such Collaboration Product. 

1.68 “Commercially Reasonable Efforts” means with respect to the efforts to be expended by a Party with
respect to any objective, [***]. 
 1.69 “Committee” means the POC Committee, [***], Joint Steering
Committee, Joint Development Committee, Joint Manufacturing Committee or Joint Commercialization Committee, or any other subcommittee, as applicable. 

  
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 1.70 “Competitive Infringement” has the meaning set forth in
Exhibit J. 
 1.71 “Competitive PCV Product”
means[***].  
 1.72 “Competitive SAV Product” means
[***]. 
 1.73 “Confidential CMC Data” means, with respect to a product, all [***] CMC-related data and information for such product. 
 1.74 “Confidential CMC
Documents” has the meaning set forth in Exhibit G. 
 1.75 “Confidential Information” has
the meaning set forth in Section 12.1(a). 
 1.76 “Contracting Party” has the meaning set forth in
Exhibit F. 
 1.77 “Control” or “Controlled” means, with respect to any Know-How, Patent or other intellectual property right, the possession (whether by ownership, license or sublicense, other than by a license, sublicense or other right granted (but not assignment) pursuant to this
Agreement) by a Party (or its Affiliate) of the ability to assign or grant to the other Party the licenses, sublicenses or rights to access and use such Know-How, Patent or other intellectual property right as
provided for in this Agreement, without violating the terms of any agreement or other arrangement with any Third Party in existence as of the time such Party would be required hereunder to grant such license, sublicense, or rights of access and use.
Know-How, Patents or other intellectual property rights that are licensed to a Party or its Affiliates or jointly owned by a Party or its Affiliates, on the one hand, and a Third Party, on the other hand, in
each case pursuant to an In-License are not “Controlled” by such Party or its Affiliates for purposes of this Agreement unless and only after such agreement is included hereunder as an Included In-License pursuant to Exhibit F. 
 1.78 “Cost of Goods Sold” has
the meaning set forth in the Financial Definitions Exhibit. 
 1.79 “Credit Against Profits Mechanism” has
the meaning set forth in Exhibit D. 
 1.80 “CTA” means an application to a Regulatory Authority for
purposes of requesting the ability to start or continue a Clinical Study, which CTA may consist of, or include, an IND. 

1.81 “Development” means any and all clinical drug development activities, Clinical Studies, statistical
analysis and report writing, the preparation and submission of Regulatory Filings, regulatory affairs with respect to the foregoing and all other activities necessary or reasonably useful or otherwise requested or required by a Regulatory Authority
as a condition or in support of obtaining or maintaining a Regulatory Approval for a product, and “Develop”, “Developed” and “Developing” will have corresponding meanings. For clarity, Development
excludes any Research, Commercialization or Manufacturing activities. 
 1.82 “Development Costs” has the
meaning set forth in the Financial Definitions Exhibit. 

  
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 1.83 “Development Plan(s)” means, with respect to a Program,
collectively, the Joint Development Plan and Budget and any Independent Additional Study Development Plan(s) for such Program. 

1.84 “Development Transition Plan” has the meaning set forth in Section 4.3(b). 

1.85 “DOJ” has the meaning set forth in Section 14.1. 

1.86 “Directed” means [***]. 

1.87 “Direct Manufacturing Costs” shall be calculated consistent with GAAP and include [***]. 

1.88 “Direct Marketing Expenses” has the meaning set forth in the Financial Definitions Exhibit. 

1.89 “Disclosing Party” has the meaning set forth in Section 12.1(a). 

1.90 “Dispute Proposal” has the meaning set forth in Section 15.1(c). 

1.91 “Disputes” has the meaning set forth in Section 15.1(a). 

1.92 “Distribution Expenses” has the meaning set forth in the Financial Definitions Exhibit. 

1.93 “Distribution Matters” means all issues and decisions regarding the distribution of products, including
decisions as to whether and with which wholesalers and distributors, if any, to contract, and the terms of contracts with such wholesalers and distributors. 

1.94 “Distributor” means a Third Party [***]. 

1.95 “DMF” means any drug master file, biologics master file (types 2, 3, 4, and 5) or For Further
Manufacturing Use (FFMU) BLA, as applicable, filed with the FDA, and any equivalent filing in other countries or regulatory jurisdictions, including active substance master files submitted to the EMA. 

1.96 “Effective Date” has the meaning set forth in the Recitals. 

1.97 “EMA” means the Regulatory Authority known as the European Medicines Agency and any successor agency
thereto. 
 1.98 “Equity Agreement” means the Series H Preferred Stock Purchase Agreement, dated as of the
Amended Effective Date, by and among Moderna Therapeutics, Inc. and the investors listed therein. 
 1.99 “ex-U.S. Antitrust Filing” has the meaning set forth in Section 15.19. 

1.100 “Exclusions Lists” has the meaning set forth in Section 1.403. 

  
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 1.101 “Executive Officer” means, for Moderna, [***], and for
Merck, [***]. Either Party may change its Executive Officer upon written notice to the other Party, provided that such replacement individual has decision-making authority on behalf of such Party in respect of this Agreement. 

1.102 “Expert” means a person with no less than [***] of pharmaceutical industry experience and expertise
having occupied at least one senior position within a large pharmaceutical company relating to commercialization and/or licensing but excluding any current or former employee or consultant of either Party or its Affiliates. Such person shall be
fluent in the English language. 
 1.103 “Expert Committee” has the meaning set forth in Exhibit C.

 1.104 “FDA” means the United States Food and Drug Administration and any successor agency thereto. 

1.105 [***] 

1.106 [***] 

1.107 “Financial Definitions Exhibit” means Exhibit B. 

1.108 “Financial PCV” has the meaning set forth in the Financial Definitions Exhibit. 

1.109 “Financial SAV” has the meaning set forth in the Financial Definitions Exhibit. 

1.110 “First Commercial Sale” means, with respect to any Collaboration Product or a Financial PCV or Financial
SAV in a country, the first commercial sale by a Selling Party to a Third Party on arm’s length terms for end use or consumption of such Collaboration Product or a Financial PCV or Financial SAV, as the case may be, in such country after all
required Regulatory Approvals for commercial sale of the applicable Collaboration Product or a Financial PCV or Financial SAV have been obtained in such country. Sales prior to receipt of Regulatory Approval for such Collaboration Product or a
Financial PCV or Financial SAV, such as so-called “treatment IND sales”, “named patient sales”, and “compassionate use sales” shall not be construed as a First Commercial Sale.

 1.111 “FTC” has the meaning set forth in Section 14.1. 

1.112 “FTE” means the equivalent of a full-time scientific or technical person’s work time over a twelve
(12) month period (including normal vacation, sick days and holidays) devoted to, and directly related to, conducting activities under this Agreement, in accordance with this Agreement, based on [***] person-hours or greater per year. In the
event that an individual devotes less than such full time to conducting activities under this Agreement in accordance with this Agreement during such twelve (12) month period, then for purposes of this Agreement, such individual shall only
count as a portion of an FTE which shall be determined by dividing the number of full days during the applicable twelve (12) month period devoted to, and directly related to, conducting activities under this Agreement in accordance with this
Agreement by the total number of working days during such twelve (12) month period. No individual may be charged at greater than one (1) FTE in a given Calendar Year. 

  
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 1.113 “FTE Costs” means, the actual FTEs employed by Moderna,
Merck or their respective Affiliates or Sublicensees in the conduct of any activities under this Agreement multiplied by the FTE Rate, which represents [***]. 

1.114 “FTE Rate” means [***] per one (1) full FTE per full twelve (12) month Calendar Year;
provided, that, starting [***], such rate shall adjust [***] of each Calendar Year by an amount equal to the change, if any, in [***]. Notwithstanding the foregoing, for any Calendar Year during the Term that is less than a full year, the above
referenced rate shall be proportionately reduced to reflect such portion of such full Calendar Year. 
 1.115
“GAAP” means U.S. generally accepted accounting principles or International Financial Reporting Standards, consistently applied, as designated and used by the applicable Party. 

1.116 “General PCV” means [***], but excluding any General SAV. 

1.117 “General SAV” means [***], but excluding any General PCV. 

1.118 “Global Commercialization Budget” has the meaning set forth in Section 8.4(b). 

1.119 “Global Commercialization Plan” means, with respect to a Collaboration Product, a written plan that
describes the plans for the Commercialization of such Collaboration Product in the Territory, including [***]. Each Global Commercialization Plan will be updated from time to time in accordance with Section 8.4(c). 

1.120 “Good Clinical Practice” or “GCP” means the applicable then-current Good Clinical
Practices as such term is defined from time to time by the FDA or other relevant Regulatory Authority having jurisdiction over the development, manufacture or sale of products pursuant to its regulations, guidelines or otherwise, as applicable. 

1.121 “Good Laboratory Practice” or “GLP” means the applicable then-current standards for
laboratory activities for pharmaceuticals (including biologicals) or vaccines, as applicable, as set forth in the Act, together with any similar standards of good laboratory practice as are required by any Regulatory Authority having jurisdiction
over the applicable activity. 
 1.122 “Gross Profit” has the meaning set forth in the Financial Definitions
Exhibit. 
 1.123 “HSR Act” means the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and
the rules promulgated thereunder. 
 1.124 “HSR Filing” means any filing with the United States Federal
Trade Commission and the Antitrust Division of the United States Department of Justice of a Notification and Report Form for Certain Mergers and Acquisitions (as that term is defined in the HSR Act) with respect to the subject matter of this
Agreement, together with all required documentary attachments thereto. 

  
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 1.125 “Human Materials” has the meaning set forth in
Section 5.2. 
 1.126 “IAS Costs” has the meaning set for in the Financial Definitions Exhibit. 

1.127 “IAS Party” has the meaning set forth in Section 7.1(b). 

1.128 [***] 

1.129 [***] 

1.130 [***] 

1.131 “In-License” means a Moderna
Pre-Existing In-License, Moderna New In-License or a Merck In-License. 

1.132 “In-License Upfront Payment” has the meaning set forth in
Section 2(a) of Exhibit F. 
 1.133 “Included
In-License” means an Included Moderna In-License or an Included Merck In-License. 

1.134 “Included In-License IP” means Patents and Know-How in-licensed by a Party from a Third Party pursuant to an Included In-License, including any extensions or expansions of the
scope thereof. 
 1.135 “Included In-License Payments” means, with
respect to a Contracting Party and an Included In-License, any amounts paid or payable during the Term by such Contracting Party under such Included In-License that are
or were incurred by or on behalf of such Contracting Party or its Affiliates as a result of (a) [***], (b) the grant of [***], (c) the grant or exercise [***] or (d) [***], in each case ((a)-(d)), under and in accordance with the terms of this
Agreement, but excluding in all cases [***]; provided, however, that the Parties will agree on [***]. 
 1.136
“Included Merck In-License” has the meaning set forth in Section 1(c) of Exhibit F. 

1.137 “Included Moderna In-License” means an Included
Moderna New In-License, an Included Moderna Pre-Existing In-License or an Included Permitted
In-License. 
 1.138 “Included Moderna New In-License” has the meaning set forth in Section 1(b)(ii) of Exhibit F. 

1.139 “Included Moderna Pre-Existing In-License” has the meaning set forth in Section 1(a) of Exhibit F. 

1.140 “Included Permitted In-License” has the meaning set forth in
Section 1(d) of Exhibit F. 
 1.141 [***] 

  
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 1.142 [***] 

1.143 [***] 

1.144 [***] 

1.145 “IND” means an Investigational New Drug Application filed with the FDA pursuant to 21 C.F.R. §312
before the commencement of human clinical trials involving a product, including all amendments and supplements to such application, or any equivalent filing with any Regulatory Authority outside the United States. 

1.146 “IND-Enabling Studies” means, for a given SAV Program, the non-clinical pharmacology studies (including pharmacokinetic and toxicology studies) identified in the POC Plan for such SAV Program that are intended to be performed prior to filing an IND/CTA with respect to the
SAVs that are being Researched for such SAV Program under the POC Plan. 
 1.147 “Indemnification Claim
Notice” has the meaning set forth in Section 13.6(c). 
 1.148 “Indemnified Party” has the
meaning set forth in Section 13.6(c). 
 1.149 “Independent Additional Study” has the meaning set forth
in Section 4.4(a)(ii). 
 1.150 “Independent Additional Study Development Plan” has the meaning set
forth in Section 4.4(a)(ii). 
 1.151 “Indirect Manufacturing Costs” shall be calculated consistent
with GAAP and include [***]. 
 1.152 “Indirect Marketing Expenses” has the meaning set forth in the
Financial Definitions Exhibit. 
 1.153 “Individualized Neoepitope(s)” means [***]. 

1.154 “Initial PCV POC Program Funding Amount” means Two Hundred Million Dollars ($200,000,000). 

1.155 “Initiation” of a Program means, (i) with respect to the PCV Program, [***], (ii) with respect to
the KRAS Program, [***], (iii) with respect to any Internal SAV Program, [***] and (iv) with respect to any other Joint SAV Program, [***]. 

1.156 “Internal SAV Program” means the Research by a Party or its Affiliates of SAVs Directed against a given
Target(s) under the Collaboration in accordance with an Internal SAV Program Plan for such Target(s), which the other Party [***] in accordance with Section 3.1(d)(i). 

1.157 “Internal SAV Program Plan” means a written plan that has been prepared by the Party conducting an
Internal SAV Program. 
 1.158 “Internal SAV Program Term” means, with respect to a given Internal SAV
Program, the period commencing on [***]. 

  
 13 

 1.159 “IP Committee” means the intellectual property advisory
committee as more fully described in Paragraph 1.1 of Exhibit J. 
 1.160 “ISP Party” means the Party
conducting a given Internal SAV Program pursuant to the applicable Internal SAV Program Plan. 
 1.161 “Issuing
Party” has the meaning set forth in Section 12.3(c). 
 1.162 “Joint Commercialization
Committee” or “JCC” has the meaning set forth in Section 2.7. 
 1.163 “Joint
Development Committee” or “JDC” has the meaning set forth in Section 2.5. 
 1.164
“Joint Development Plan and Budget” has the meaning set forth in Section 4.3(c)(i). 
 1.165
“Joint Development Program” has the meaning set forth in Section 4.1(c). 
 1.166 “Joint
Development Study” has the meaning set forth in Section 4.4(a)(i). 
 1.167 “Joint Know-How” means all Collaboration Know-How within [***] that is jointly owned by the Parties in accordance with Section 11.4. 

1.168 “Joint Manufacturing Committee” or “JMC” has the meaning set forth in
Section 2.6(a). 
 1.169 “Joint Patents” means all Collaboration Patents within [***] that are jointly
owned by the Parties in accordance with Section 11.4. 
 1.170 “Joint SAV Program” means the
collaborative Research, Development and Manufacture by the Parties or their respective Affiliates of SAVs (including Collaboration SAV Products) Directed against a given SAV Target(s) in accordance with the POC Plan for such SAV Target(s), and if
Merck exercises the applicable Merck Participation Election and pays the Participation Election Payment, the further Research of SAVs (including Collaboration SAV Products) Directed against such SAV Target(s) in accordance with an Additional
Research Plan, and the Development, Manufacture and Commercialization of Collaboration SAV Products Directed against such SAV Target(s) by or on behalf of one or more of the Parties under the Collaboration in accordance with this Agreement. [***]

 1.171 “Joint Steering Committee” or “JSC” has the meaning set forth in Section 2.4.

 1.172 “Joint Technology” means all Joint Know-How and Joint
Patents. 
 1.173 “Keytruda” means Merck’s human pharmaceutical product Keytruda® (pembrolizumab).  

  
 14 

 1.174 “Know-How” means
all non-public technical, scientific, and other know-how and information, trade secrets, knowledge, technology, means, methods, processes, practices, formulae,
instructions, skills, techniques, procedures, experiences, ideas, designs, drawings, assembly procedures, Software, computer programs, apparatuses, specifications, data, results and materials, including: biological, chemical, vaccine-related,
pharmacological, toxicological, pharmaceutical, physical and analytical, pre-clinical, clinical, safety, manufacturing and quality control data and information, including study designs and protocols, assays,
and biological methodology, in all cases, whether or not copyrightable or patentable, in written, electronic or any other form now known or hereafter developed. 

1.175 “Knowledge” means with respect to the matter in question, the knowledge of any [***]. 

1.176 “KRAS” means [***]. 

1.177 “KRAS POC Program” has the meaning set forth in Section 3.1(b). 

1.178 “KRAS Program” means the Research, Development and Manufacture of SAVs (including Collaboration SAV
Products) Directed against KRAS in accordance with the POC Plan for KRAS, and if Merck exercises the applicable Merck Participation Election and pays the applicable Participation Election Payment, the further Research of SAVs (including
Collaboration SAV Products) Directed against KRAS in accordance with an Additional Research Plan, and the Development, Manufacture and Commercialization of Collaboration SAV Products Directed against KRAS by or on behalf of one or more of the
Parties under the Collaboration in accordance with this Agreement. 
 1.179 “KRAS Transition Date” has the
meaning set forth in Section 3.4(c)(ii). 
 1.180 “KRAS Transition Plan” has the meaning set forth in
Section 3.4(c)(ii). 
 1.181 “Law” or “Laws” means all laws, statutes, enactments,
acts of legislature, rules, regulations, orders, judgments, guidelines, policies, directions, directives, or ordinances having the effect of law of any federal, national, multinational, state, provincial, county, city or other political subdivision
of any jurisdiction which are applicable to any of the Parties or their respective Affiliates in carrying out activities hereunder or to which any of the Parties or their respective Affiliates in carrying out the activities hereunder is subject,
including the Act and GLPs, GCPs and cGMPs. 
 1.182 “Lead Regulatory Party” means, for a given Program, the
POC Lead Regulatory Party or the Merck Participation Term Lead Regulatory Party, as applicable. 
 1.183 [***] 

1.184 [***] 

1.185 [***] 

1.186 “Losses” has the meaning set forth in Section 13.6(a). 

  
 15 

 1.187 “Manufacturing” means the production, manufacture,
synthesis, processing, filling, formulating, finishing, packaging, labeling, shipping and holding of product or any intermediate thereof (including with respect to a PCV, receipt of patient samples, sequencing, identifying and analyzing tumor
specific mutations (e.g., using sequencing or genomics tools)), process development, process qualification and validation, scale-up, commercial manufacture and analytic development, product
characterization, stability testing, quality assurance and quality control. “Manufacturing” refers to both pre-clinical and clinical Manufacturing for Research and Development, and Manufacturing for
Commercialization. “Manufacture” and “Manufactured” will have corresponding meanings. For clarity, “Manufacturing” excludes Research, Development or Commercialization activities. 

1.188 “Manufacturing Capacity Forecast” has the meaning set forth in Section 6.2(g)(i). 

1.189 “Manufacturing Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.190 “Manufacturing Subcontractor” means, with respect to Merck, any Third Party that, as a contract
manufacturer (for example, as of the Amended Effective Date, the Third Parties listed on Exhibit L-1) of Merck or any of its Affiliates, may Manufacture the applicable cGMP Collaboration Product in
connection with a technology transfer pursuant to this Agreement or the PCV Clinical Supply Agreement, the SAV Clinical Supply Agreement, Commercial Supply Agreement, [***] (as applicable), which Third Party is designated by Merck and is reasonably
acceptable to Moderna (and in all cases those listed on Exhibit L-1 are deemed acceptable); provided that Moderna may only determine that a Third Party selected by Merck to act as a contract
manufacturer of Merck (or its Affiliate) is not reasonably acceptable [***] if (a) such Third Party manufacturer or its Affiliate is a biotech or pharmaceutical company [***] that Researches, Develops or Commercializes (i) [***] (for example,
as of the Amended Effective Date, the Third Parties listed on Exhibit L-2), or (ii) [***] (for example, as of the Amended Effective Date, the Third Parties listed on Exhibit L-2), or (b) with respect to Third Party manufacturing in [***], Moderna has reasonable concerns [***] relating to [***]. 

1.191 “Material(s)” means any tangible chemical or biological material, including any compounds, DNA and RNA
(modified and unmodified), mRNA Constructs, polypeptides, clones, cells, plasmids, lipids, vectors, receptors, any other nucleic acids, proteins, peptides and any expression product, progeny, derivative or other improvement thereto, along with any
tangible chemical or biological material embodying any Know-How. 
 1.192
“Medical Affairs” means, with respect to a product, the performance of activities with respect to: continuing medical education therefor; development, publication and dissemination of publications; exhibiting and presenting at
seminars and conventions; conducting health economic studies; conducting speakers programs; conducting appropriate activities involving opinion leaders; engaging medical science liaisons and conducting medical science liaison activities; disease
education to health care professionals and consumers; conducting advisory board meetings or other consultant programs; and establishing clinical consumer and patient registries. 

1.193 “Medical Affairs Costs” has the meaning set forth in the Financial Definitions Exhibit. 

  
 16 

 1.194 “Merck” has the meaning set forth in the Recitals. 

1.195 “Merck Acquisition” has the meaning set forth in Section 10.8(d)(ii). 

1.196 “Merck Acquisition Program” has the meaning set forth in Section 10.8(d)(ii). 

1.197 “Merck Agent” means any [***] Controlled by Merck or its Affiliates (but not [***]). 

1.198 “Merck Agent Technology” has the meaning set forth in Section 11.3. 

1.199 “Merck Background Know-How” means, on a Program-by-Program basis, subject to Section 10.12, any and all Know-How Controlled by Merck or its Affiliates (a) as of the
date of Initiation of such Program, or (b) as to which Merck or its Affiliates obtains Control during the Collaboration Term for such Program, in each case ((a)-(b)) that [***], excluding [***] Merck’s rights in any Collaboration Know-How. 
 1.200 “Merck Background Patents” means, on a Program-by-Program basis, subject to Section 10.12, those Patents that are Controlled by Merck or its Affiliates (a) as of the date of Initiation of such Program, or
(b) as to which Merck or its Affiliates obtains Control during the Collaboration Term for such Program, in each case ((a)-(b)) that claim or cover the Merck Background Know-How for such Program, excluding
in each case ((a) and (b)) Merck’s rights in any Collaboration Patents. 
 1.201 “Merck Background
Technology” means Merck Background Know-How and Merck Background Patents. 

1.202 “Merck Business Combination Program” has the meaning set forth in Section 10.8(d)(i). 

1.203 “Merck Cessation Election” has the meaning set forth in Section 10.10. 

1.204 [***] 

1.205 [***] 

1.206 “Merck General Patents” means Merck Background Patents, excluding [***]. 

1.207 “Merck In-License” has the meaning set forth in
Section 1(c) of Exhibit F. 
 1.208 “Merck Indemnitees” has the meaning set
forth in Section 13.6(b). 
 1.209 “Merck Internal SAV Program” means an Internal SAV Program being
conducted by Merck or its Affiliates. 
 1.210 [***] 

1.211 “Merck Non-Participation” has the meaning set forth in
Section 3.7(a). 

  
 17 

 1.212 “Merck Participation Election” has the meaning set forth
in Section 3.5(b). 
 1.213 “Merck Participation Election Date” means, with respect to the PCV Program
or a given Joint SAV Program, [***]. 
 1.214 “Merck Participation Election Notice” has the meaning set
forth in Section 3.5(c). 
 1.215 “Merck Participation Election Period” means, with respect to the PCV
Program or a given Joint SAV Program, the period commencing on the date of Initiation of such Program and ending upon the earliest of [***]. 

1.216 “Merck Participation Term” means, for the PCV Program or a given Joint SAV Program, the period
commencing on the Merck Participation Election Date for such Program and ending upon [***]. 
 1.217 “Merck
Participation Term Lead Regulatory Party” means [***] with respect to the PCV Program or any Joint SAV Program, unless otherwise agreed to by the Parties in writing with respect to a given Program. 

1.218 “Merck Patents” means the Merck General Patents and the [***]. 

1.219 [***] 

1.220 “Merck Program Director” has the meaning set forth in Section 2.2. 

1.221 [***] 

1.222 [***] 

1.223 “Merck Reimbursement Cap” has the meaning set forth in Exhibit E. 

1.224 “Merck Representatives” has the meaning set forth in Exhibit G. 

1.225 [***] 

1.226 “Merck SAV Program Costs” means, [***]. 

1.227 [***] 

1.228 “Merck Technology” means collectively, Merck Background Technology and Merck’s interest in
Collaboration Technology. 
 1.229 “Moderna” has the meaning set forth in the Recitals. 

1.230 [***] 

1.231 [***] 

  
 18 

 1.232 “Moderna Agent” means any [***] Controlled by Moderna or
its Affiliates (but not Collaboration Products). 
 1.233 “Moderna Agent Technology” has the meaning
set forth in Section 11.2. 
 1.234 “Moderna Background
Know-How” means, on a Program-by-Program basis, subject to Section 10.12, any and all Know-How Controlled by Moderna or any of its Affiliates (a) as of the date of Initiation of such Program, including [***], or (b) as to which Moderna or any of its Affiliates obtains Control during the
Collaboration Term for such Program, in each case ((a)-(b)) that [***], excluding [***] Moderna’s rights in any Collaboration Know-How. 

1.235 “Moderna Background Patents” means, on a Program-by-Program basis, subject to Section 10.12, those Patents that are Controlled by Moderna or any of its Affiliates [***] that claim or cover the Moderna Background
Know-How for such Program, excluding [***] Moderna’s rights in any Collaboration Patents. 

1.236 “Moderna Background Technology” means Moderna Background
Know-How and Moderna Background Patents. 
 1.237 “Moderna Business
Combination Program” has the meaning set forth in Section 10.7(e)(i). 
 1.238 “Moderna CMC
Information” means, with respect to the PCV Program or a Joint SAV Program under this Agreement, the Confidential CMC Data of Moderna or its Affiliates with respect to a product that is Researched, Developed, Manufactured and/or
Commercialized under the PCV Program or such Joint SAV Program. 
 1.239 [***] 

1.240 [***] 

1.241 [***] 

1.242 “Moderna Commercialization Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.243 “Moderna Costs Report” has the meaning set forth in Exhibit E. 

1.244 “Moderna Development Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.245 [***] 

1.246 “Moderna General Patents” means [***]. 

1.247 “Moderna Indemnitees” has the meaning set forth in Section 13.6(a). 

1.248 “Moderna Internal SAV Program” means an Internal SAV Program being conducted by Moderna or its
Affiliates. 

  
 19 

 1.249 “Moderna New
In-License” has the meaning set forth in Section 1(b)(i) of Exhibit F. 

1.250 “Moderna Net Profits” has the meaning set forth in the Financial Definitions Exhibit. 

1.251 [***] 

1.252 “Moderna Patents” means the Moderna General Patents, [***] and the [***]. 

1.253 [***] 

1.254 “Moderna Pre-Existing
In-License” means, a license or other agreement between Moderna or its Affiliates and a Third Party in effect as of [***]pursuant to which a Third Party grants Moderna (or its Affiliates) a license
under any Patents or Know-How that are necessary or reasonably useful for the Research, Development, Manufacture or Commercialization of mRNA Cancer Vaccines. The Moderna
Pre-Existing In-License(s) shall be set forth on Schedule 1.254. 

1.255 [***] 

1.256 [***] 

1.257 “Moderna Program Director” has the meaning set forth in Section 2.2. 

1.258 [***] 

1.259 [***] 

1.260 [***] 

1.261 [***] 

1.262 [***] 

1.263 [***] 

1.264 “Moderna Technology” means collectively, Moderna Background Technology and Moderna’s interest in
Collaboration Technology. 
 1.265 “mRNA-5671” means mRNA-5671 as described in the POC Plan for the KRAS
Program. 
 1.266 “mRNA Cancer Vaccine” means any PCVs and/or SAVs, as applicable. 

1.267 “mRNA Cancer Vaccine Technology” means any [***]. 

 1.268 “mRNA Construct” means [***]. 

  
 20 

 1.269 “mRNA-PCV Field”
means Research, Development, Manufacture or Commercialization of any PCV. 
 1.270
“mRNA-SAV Field” means Research, Development, Manufacture or Commercialization of any SAV. 

1.271 “mRNA Technology” means [***]. 

1.272 “NDA” means a new drug application or a biologics license application (a “BLA”),
including all supplements and amendments thereto and all necessary documents, data, and other information concerning a product, required for Regulatory Approval of the product as a pharmaceutical product by the FDA or an equivalent application to
the equivalent agency in any other country or group of countries (e.g. the marketing authorization application (MAA) in the EU). 

1.273 “Net Residual Amount” means the difference between (a) the Upfront Payment and (b) the POC
Program Costs for the PCV Program incurred as of the earlier of (i) [***], or (ii) [***]. 
 1.274 “Net
Sales” means the gross invoice price (not including [***]) of a Collaboration Product or Financial PCV or Financial SAV sold by a Selling Party to the first Third Party after deducting, if not previously deducted, from the amount invoiced
or received: 
 (a) [***] 

(b) [***] 

(c) [***] 

(d) [***] 

(e) [***] 

(f) [***] 

(g) [***] 

wherein the foregoing actual deductions incurred in (a) through (g) shall be determined in a manner as [***], including such Financial
PCV or Financial SAV or Collaboration Product, and for the sake of clarity, where any charge or allowance as described above in this Section 1.274 shall be counted once only. [***] With respect to a Financial PCV or Financial SAV or
Collaboration Product that is sold as a Combination Product, Net Sales of such Financial PCV or Financial SAV or Collaboration Product shall be calculated in accordance with Exhibit C and shall not include the Relative Commercial Value of any
Other Component of such Combination Product in accordance with Exhibit C. 
 1.275 “New In-License” means a Moderna New In-License or a Merck In-License. 

1.276 “Non-Commercial Combination Activity” means [***]. 

  
 21 

 1.277 “Non-IAS Party”
has the meaning set forth in Section 7.1(b). 
 1.278 “Non-Participation
PCV Net Profit Share” has the meaning set forth in Exhibit E. 
 1.279 “Non-Participation SAV Net Profit Share” has the meaning set forth in Exhibit E. 

1.280 “Officials” has the meaning set forth in Section 5.5. 

1.281 “Original Agreement” has the meaning set forth in the Recitals. 

1.282 “Other Component” means any therapeutically or prophylactically active ingredients other than a PCV or
SAV. For clarity, an Other Component may include one or more of the following: Merck Agent, Moderna Agent, Third Party Agent or [***]. 

1.283 “Other Operating Income/Expense” has the meaning set forth in the Financial Definitions Exhibit. 

1.284 “Other SAV POC Program” has the meaning set forth in Section 3.1(c)(iv). 

1.285 “Out-of-Pocket Costs”
has the meaning set forth in the Financial Definitions Exhibit. 
 1.286 “P&L” has the meaning set forth
in Exhibit D. 
 1.287 “Participation Election Payment” has the meaning set forth in
Section 9.3(a)(ii). 
 1.288 “Parties” has the meaning set forth in the Recitals. 

1.289 “Party” has the meaning set forth in the Recitals. 

1.290 “Patent” means (a) a patent or a patent application, (b) any additions, priority applications,
divisions, continuations, and continuations-in-part of any of the foregoing and (c) all patents issuing on any of the foregoing patent applications, together with
all invention certificates, substitutions, reissues, reexaminations, registrations, supplementary protection certificates, confirmations, renewals and extensions of any of (a), (b) or (c), and foreign counterparts of any of the foregoing. 

1.291 “Patent and Trademark Expenses” has the meaning set forth in the Financial Definitions Exhibit. 

1.292 “Patent Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.293 “Payment” has the meaning set forth in Section 5.5. 

1.294 “PCV” means [***]. 

1.295 “PCV Cessation Net Profit Share” has the meaning set forth in Exhibit E. 

1.296 “PCV Clinical Supply Agreement” has the meaning set forth in Section 6.2(d). 

  
 22 

 1.297 “PCV Participation Election Payment” has the meaning set
forth in Section 9.3(a)(i). 
 1.298 “PCV POC Program” has the meaning set forth in
Section 3.1(a). 
 1.299 “PCV POC Term” has the meaning set forth in Section 3.2(a) 

1.300 “PCV Program” means the Research, Development and Manufacture of PCVs (including Collaboration PCV
Products) in accordance with the POC Plan for PCVs, and if Merck exercises the applicable Merck Participation Election, the further Research of PCVs (including Collaboration PCV Products) in accordance with an Additional Research Plan, and the
Development, Manufacture and Commercialization of Collaboration PCV Products by or on behalf of one or more of the Parties under the Collaboration in accordance with this Agreement. For clarity, the PCV Program shall be separate from each SAV
Program. 
 1.301 [***]. 

1.302 “Permitted In-License” has the meaning set forth in
Section 1(d) of Exhibit F. 
 1.303 [***] 

1.304 “Person” means any individual, partnership, joint venture, limited liability company, corporation, firm,
trust, association, unincorporated organization, governmental authority or agency, or any other entity not specifically listed herein. 

1.305 “Pharmacovigilance Agreement” has the meaning set forth in Section 7.3. 

1.306 “Phase I Clinical Study” shall mean a human clinical trial in any country that would satisfy the
requirements of 21 CFR 312.21(a). 
 1.307 “Phase II Clinical Study” shall mean a human clinical trial in
any country that would satisfy the requirements of 21 CFR 312.21(b). 
 1.308 “Phase III Clinical Study”
shall mean a human clinical trial in any country that would satisfy the requirements of 21 CFR 312.21(c). 
 1.309
“Phase IV Clinical Study” means (i) any human clinical trial (other than a Phase I Clinical Study, Phase II Clinical Study or Phase III Clinical Study) in any country which is conducted on a product after Regulatory Approval of
such product has been obtained from an appropriate Regulatory Authority, and includes clinical trials conducted voluntarily after Regulatory Approval for enhancing marketing or scientific knowledge of an approved indication or (ii) any REMS/RMP
related study of a product after Regulatory Approval. 
 1.310 “Plans” means, with respect to a given
Program, the Internal SAV Program Plan, the POC Plan, the Joint Development Plan and Budget and the Global Commercialization Plan for such Program. 

1.311 [***] 

  
 23 

 1.312 [***] 

1.313 “POC Committee” has the meaning set forth in Section 2.3(a). 

1.314 “POC Data Package” means, with respect to a given Program, the data package of data and information to
be generated and collected under a POC Plan for such Program, which data package will in any event include: [***]; provided that with respect to an SAV POC Program, [***]. 

1.315 “POC Lead Regulatory Party” means, for a given POC Program, [***]. 

1.316 [***] 

1.317 “POC Plan” has the meaning set forth in Section 3.3(a). 

1.318 “POC Pharmacovigilance Agreement” has the meaning set forth in Section 3.4(m). 

1.319 “POC Program” has the meaning set forth in Section 3.1(c)(iv). 

1.320 “POC Program Costs for the PCV Program” means, with respect to the PCV Program, the internal costs
(i.e., FTE Costs) and Out-of-Pocket Costs actually incurred by or on behalf Moderna (or its Affiliates) and that are [***] to the conduct of the POC Plan for the
PCV Program, including: 
 (a) [***] 

(b) [***] 

(c) [***] 

(d) [***] 

(e) [***] 

(f) [***] 

(g) [***] 

With respect to the foregoing, any internal costs shall be calculated based on the number of FTEs used to perform the
applicable activity multiplied by the FTE Rate. 
 1.321 “POC Term” has the meaning set forth in
Section 3.2(b). 
 1.322 “Post-Marketing Study” means a
non-human pre-clinical study or human Clinical Study of a product initiated after receipt of Regulatory Approval for such product in a country or territory, which is
required by the Regulatory Authority in such country or territory to maintain the Regulatory Approval for such product in such country or territory. 

  
 24 

 1.323 “Pre-Existing
Restriction” means [***]. 
 1.324 “Pre-GLP Tox Commitment
Date” means, with respect to a given Internal SAV Program, the earlier of (a) the date of the ISP Party’s selection of a Lead SAV Candidate for such Internal SAV Program, or (b) the effective date of expiration or termination
of the SAV Research Term. 
 1.325 “Pre-GLP Tox Data Package” means,
with respect to a given Internal SAV Program, the data package of data and information to be generated and collected for such Internal SAV Program, which data package will in any event include [***]. 

1.326 “Pre-GLP Tox Election” has the meaning set forth in
Section 3.1(d)(iv). 
 1.327 “Pre-GLP Tox Election Date” means,
with respect to a given Internal SAV Program, the date of the Pre-GLP Tox Election Notice for such Internal SAV Program. 

1.328 “Pre-GLP Tox Election Notice” has the meaning set forth in
Section 3.1(d)(v). 
 1.329 “Pricing Matters” means all issues and decisions regarding (a) price,
price terms and other contract terms with respect to Collaboration Product sales, including discounts, rebates, other price concessions and service fees to payors and purchasers and (b) reimbursement programs applicable to a Collaboration
Product. 
 1.330 “Primary POC PCV Funding Amount” has the meaning set forth in Section 3.4(g)(i)(2).

 1.331 “Product Specific Manufacturing Variances” has the meaning set forth in the Financial Definitions
Exhibit. 
 1.332 “Profit & Loss Share” has the meaning set forth in
Section 9.3(b). 
 1.333 “Profitability Date” has the meaning set forth in the Financial Definitions
Exhibit. 
 1.334 “Program” means the PCV Program or any SAV Program (including the KRAS Program), as
applicable. 
 1.335 “Program Directors” has the meaning set forth in Section 2.2. 

1.336 “Promotional Materials” means all sales representative training materials and all written, printed,
graphic, electronic, audio or video matter, including journal advertisements, sales visual aids, leave-behind items, formulary binders, reprints, direct mail,
direct-to-consumer advertising, internet postings and sites and broadcast advertisements intended for use or used by or on behalf of either Party or their respective
Affiliates in connection with any promotion of a Collaboration Product. 
 1.337 “Prosecution and
Maintenance” means, with regard to a particular Patent or claim within a Patent, the preparation, filing, prosecution and maintenance of such Patent or claim, as well as re-examinations, reissues and
the like with respect to such Patent or claim, together with the conduct of interferences, the defense of oppositions and other similar proceedings with respect to such Patent or claim. The term “Prosecute and Maintain” shall have a
corresponding meaning. 

  
 25 

 1.338 “Providers” has the meaning set forth in Section 5.2.

 1.339 “Qualification Standards” means the customary, reasonable standards and criteria to be applied
[***]. 
 1.340 “Quality Agreements” means the Clinical Quality Agreement(s) and the Commercial Quality
Agreement(s). 
 1.341 [***] 

1.342 “Receiving Party” has the meaning set forth in Section 12.1(a). 

1.343 “Reconciliation Report” has the meaning set forth in Exhibit D. 

1.344 “Registrational Study” means, with respect to the United States, a Clinical Study of a product on
sufficient numbers of patients that is designed to establish that such product is safe and efficacious for its intended use, and to define warnings, precautions and adverse reactions that are associated with such product in the dosage range to be
prescribed, and to support Regulatory Approval of such product or label expansion of such product, as described under 21 C.F.R. §312.21(c), or, with respect to a jurisdiction other than the United States, an equivalent clinical trial. 

1.345 “Regulatory Approval” means, with respect to a country or extra-national territory, any and all
approvals (including NDAs), licenses, registrations or authorizations of any Regulatory Authority necessary in order to commercially distribute, sell or market a product in such country or some or all of such extra-national territory, including any
pricing or reimbursement approvals. 
 1.346 “Regulatory Authority” means any national (e.g., the
FDA), supra-national (e.g., the EMA), regional, state or local regulatory agency, department, bureau, commission, council or other governmental entity, in any jurisdiction in the world, involved in the granting of Regulatory Approval or
otherwise involved in regulating the Research, Development, Manufacture or Commercialization of a product. 
 1.347
“Regulatory Filing” means any submission to a Regulatory Authority, including all applications, registrations, licenses, authorizations and approvals (including Regulatory Approvals), together with any related correspondence and
documentation submitted to or received from Regulatory Authorities (including minutes and official contact reports relating to any communications with any Regulatory Authority) and all supporting documents and all clinical studies and tests,
relating to a product and all data contained in any of the foregoing, including all INDs, NDAs, CTAs, regulatory drug lists, advertising and promotion documents, Clinical Data, Adverse Event files and complaint files, and include any submission to a
regulatory advisory board, marketing authorization application, and any supplement or amendment thereto. 

  
 26 

 1.348 “Relative Commercial Value” has the meaning set forth in
Exhibit C. 
 1.349 “Release” has the meaning set forth in Section 12.3(c). 

1.350 “Released Target” means [***]. 

1.351 [***] 

1.352 “Research” means activities related to the design, discovery, identification, research, pre-clinical development, preclinical toxicology studies, profiling, characterization, improvement or optimization of a product. For clarity, “Research” excludes Development, Commercialization or
Manufacturing activities. The term “Researched” has a corresponding meaning.  

1.353 [***] 

1.354 “Reviewing Party” has the meaning set forth in Section 12.3(c). 

1.355 “Right of Reference” means the “right of reference” defined in 21 CFR 314.3(b), including,
with respect to a Party, allowing the applicable Regulatory Authority in a country to have access to relevant information (by cross-reference, incorporation by reference or otherwise) contained in Regulatory Filings (and any data contained therein)
filed with such Regulatory Authority with respect to such Party’s product, only to the extent necessary for the conduct of Research, Development, Manufacturing or Commercialization activities for such product in such country or as otherwise
expressly permitted or required under this Agreement to enable the other Party to exercise its rights or perform its obligations hereunder. 

1.356 “Safety Issue” means, with respect to a given Collaboration Product or Other Component used in
combination with such Collaboration Product: [***]. 
 1.357 “SAV” means a messenger RNA-based therapeutic cancer vaccine intended to treat multiple patients and [***], including [***] but excluding PCVs. 

1.358 “SAV Cessation Net Profit Share” has the meaning set forth in Exhibit E. 

1.359 “SAV Clinical Supply Agreement” has the meaning set forth in Section 6.2(e). 

1.360 “SAV IND Data Package” means, for a given Joint SAV Program (other than the KRAS Program), an
information package regarding the SAVs for such Joint SAV Program that is submitted by Moderna to Merck following completion of the IND-Enabling Studies for the SAVs for such Joint SAV Program, which includes
[***]. 
 1.361 “SAV Participation Election Payment” has the meaning set forth in Section 9.3(a)(ii).

 1.362 “SAV POC Program” has the meaning set forth in Section 3.1(c)(iv). 

1.363 “SAV POC Term” has the meaning set forth in Section 3.2(b). 

  
 27 

 1.364 “SAV Program” means (a) a Joint SAV Program or
(b) an Internal SAV Program. For clarity, a given SAV Program will be separate from each other SAV Program, and each SAV Program shall also be separate from the PCV Program. If agreed to by the Parties, a given SAV Program may include more than
one Target. 
 1.365 “SAV Research Term” means the period from the Amended Effective Date until the earlier
of [***]. 
 1.366 [***] 

1.367 “SAV Target” means (a) for the KRAS Program, KRAS, or (b) for any other Joint SAV Program, any
Target(s) (other than KRAS) that the Parties mutually agree to include in such Joint SAV Program pursuant to the POC Plan for such Joint SAV Program. 

1.368 “SAV Target Notice” has the meaning set forth in Section 3.1(c)(i). 

1.369 “SEC” has the meaning set forth in Section 12.3(b). 

1.370 “Selling Expenses” has the meaning set forth in the Financial Definitions Exhibit. 

1.371 “Selling Party” means with respect to a Party, such Party and its Affiliates and Sublicensees, except as
otherwise provided in Exhibit D or Exhibit E. 
 1.372 [***] 

1.373 “Serious Adverse Event” or “SAE” means any untoward medical occurrence that at any
dose: results in death, is life-threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity or, is a congenital anomaly/birth defect. Medical and scientific
judgment should be exercised in deciding whether expedited reporting is appropriate in other situations, such as important medical events that may not be immediately life-threatening or result in death or hospitalization but may jeopardize the
patient or may require intervention to prevent one of the other outcomes listed in the definition above. These should also usually be considered serious. Examples of such events are intensive treatment in an emergency room or at home for allergic
bronchospasm; blood dyscrasias or convulsions that do not result in hospitalization; or development of drug dependency or drug abuse or transmission of an infectious agent via a medicinal product. 

1.374 “Shared Collaboration Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.375 “Shared Commercialization and Related Manufacturing Costs” has the meaning set forth in the Financial
Definitions Exhibit. 
 1.376 “Shared Costs Report” has the meaning set forth in Exhibit D. 

1.377 “Shared Development and Related Manufacturing Costs” has the meaning set forth in the Financial
Definitions Exhibit. 
 1.378 “Shared Neoepitope(s)” means [***]. 

  
 28 

 1.379 “Shared Losses” has the meaning set forth in the Financial
Definitions Exhibit. 
 1.380 “Shared Profits” has the meaning set forth in the Financial Definitions
Exhibit. 
 1.381 “Shared Profits or Losses” has the meaning set forth in the Financial Definitions Exhibit.

 1.382 “Significant Third Party” has the meaning set forth in Section 15.3. 

1.383 “Software” means any and all computer programs, operating systems, applications, firmware, middleware,
or software of any nature, whether operational, under development or inactive including all object code, source code, comment code, algorithms, tools, build, underlying components thereof, menu structures and arrangements, icons, operational
instructions, scripts, commands, syntax, screen designs, reports, designs, concepts, technical manuals, test scripts, user manuals and other documentation therefor, whether in machine-readable form, programming language or any other language or
symbols, and whether stored, encoded, recorded or written on disk, tape, film, memory device, paper or other media of any nature and all databases necessary or appropriate to operate any such computer programs, operating systems, applications,
firmware, middleware, or software. 
 1.384 “[***]” means [***]. 

1.385 “Special Arbitration” has the meaning set forth in Section 15.1(c). 

1.386 “Sublicense Income” means all consideration (including upfront payments, license fees, royalties and
milestone payments) [***] by a Selling Party [***], net of out-of-pocket expenses of a Selling Party incurred in connection with such [***]. 

1.387 “Sublicensee” means any Person that is granted a sublicense as permitted by Section 10.3, either
directly by a Party or indirectly by any other Sublicensee (including any Affiliate that is granted a sublicense hereunder but excluding, for clarity, any Distributors). 

1.388 “Supply Agreement” means any supply agreement entered into by the Parties pursuant to Section 6
(including the PCV Clinical Supply Agreement, SAV Clinical Supply Agreement and any Commercial Supply Agreement). For clarity, the 2016 CSA is not a Supply Agreement. 

1.389 “Supply Failure” means, with respect to the given PCV Clinical Supply Agreement, SAV Clinical Supply
Agreement, Commercial Supply Agreement or Exhibit K, the meaning given to such term in such PCV Clinical Supply Agreement, SAV Clinical Supply Agreement, Commercial Supply Agreement or Exhibit K, as applicable, for an event or
circumstance, [***]. 
 1.390 “Target” means [***]. 

1.391 “Tax” and “Taxation” means any form of tax or taxation, levy, duty, charge or
withholding (including any related fine, penalty, addition to tax, surcharge or interest) imposed by, or payable to, a governmental authority. 

  
 29 

 1.392 “Technical Failure” means with respect to a given Joint
SAV Program, [***]. 
 1.393 “Term” has the meaning set forth in Section 14.1. 

1.394 “Territory” means worldwide. 

1.395 “Testing Costs” has the meaning set forth in the Financial Definitions Exhibit. 

1.396 “Third Party” means any Person other than Moderna, Merck and their respective Affiliates. 

1.397 “Third Party Agent” means any clinical-stage compound or marketed product controlled by a Third Party
(but not any [***]). 
 1.398 “Third Party Claims” has the meaning set forth in Section 13.6(a). 

1.399 “Transparency Report” has the meaning set forth in Section 3.4(k)(vii). 

1.400 “United States” or “U.S.” means the United States of America, including its territories
and possessions, the District of Columbia and Puerto Rico. 
 1.401 “U.S. GAAP Standard Cost” has the
meaning set forth in the Financial Definitions Exhibit. 
 1.402 “Upfront Payment” has the meaning set forth
in Section 9.1. 
 1.403 “Violation” means, with respect to a Party, such Party or any of its officers
or directors or any other personnel of such Party (or other permitted agents of such Party performing activities hereunder) has been: (a) convicted of any of the felonies identified among the exclusion authorities listed on the U.S. Department
of Health and Human Services, Office of Inspector General (OIG) website, including 42 U.S.C. 1320a-7(a) (http://oig.hhs.gov/exclusions/authorities.asp); (b) identified in the OIG List of Excluded
Individuals/Entities (LEIE) database (http://exclusions.oig.hhs.gov/) or listed as having an active exclusion in the System for Award Management (http://www.sam.gov); or (c) listed by any US Federal agency as being suspended, proposed for
debarment, debarred, excluded or otherwise ineligible to participate in Federal procurement or non-procurement programs, including under 21 U.S.C. 335a (http://www.fda.gov/ora/compliance_ref/debar/) (each of
(a), (b) and (c) collectively the “Exclusions Lists”). 
  

	2.	 COLLABORATION OVERVIEW; GOVERNANCE 

2.1 Overview of Collaboration. The Parties intend and have agreed to undertake the Collaboration under this Agreement
with the primary goal to Research, Develop, Manufacture and Commercialize Collaboration Products in accordance with the Collaboration with the goal of expanding and enhancing the value of such Collaboration Products, consisting, in general, of the
following major components: 

  
 30 

 (a) a broad program to be conducted during the POC Term for the PCV Program for
the Research and Development of PCVs (including Collaboration PCV Products), pursuant to which Moderna will conduct Research and Development efforts with Merck’s participation with respect to such PCVs and establish Manufacturing capabilities
for Collaboration PCV Products, as described in the POC Plan for the PCV Program and further detailed in Section 3; 

(b) a broad program to be conducted during the POC Term for the KRAS Program, pursuant to which the Parties will conduct
Research and Development efforts with respect to SAVs Directed against KRAS (including Collaboration SAV Products Directed against KRAS) and identify Manufacturing capacity for such Collaboration SAV Products, as described in the POC Plan for the
KRAS Program and further detailed in Section 3; 
 (c) if during the SAV Research Term, the Parties do not agree to
collaborate on one or more additional Targets, then a Party and its Affiliates may conduct an Internal SAV Program, pursuant to which such Party and its Affiliates may conduct Research efforts with respect to one or more SAVs Directed against such
Target, as described in the Internal SAV Program Plan for such Internal SAV Program and further described in Section 3.1(d); 

(d) if during the SAV Research Term, the Parties mutually agree to collaborate on one or more additional SAV Targets (other
than KRAS) in accordance with Section 3.1(c), a broad program to be conducted during the POC Term for such Joint SAV Program, pursuant to which the Parties will conduct Research and Development efforts with respect to such SAVs Directed against
such SAV Target (including Collaboration SAV Products Directed against such SAV Target) and identify Manufacturing capacity for such Collaboration SAV Products, as described in the POC Plan for such Joint SAV Program and further detailed in
Section 3; 
 (e) for each given Program, Merck will have the right during the Merck Participation Election Period for
such Program to exercise the Merck Participation Election for such Program to further participate with Moderna in the further Research, Development, Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) with
respect to such Program, and to share equally the costs and benefits of, such Research, Development, Manufacture and Commercialization, subject to and in accordance with this Agreement; 

(f) for each given Program, if Merck exercises the Merck Participation Election for such Program, then, subject to Merck paying
the Participation Election Payment for such Program in accordance with Section 9.3(a), during the Merck Participation Term for such Program: 

(i) the Parties will conduct further Research and Development of mRNA Cancer Vaccines (including Collaboration Products) for
such Program through Regulatory Approval, with the activities to be jointly funded by the Parties in accordance with the terms of this Agreement; provided, however, that [***]; 

(ii) Merck shall have the sole right to Commercialize the Collaboration Products from such Program in the Territory (subject
to Moderna’s right to engage in Co-Promotion activities in the United States under and in accordance with Sections 8.5 and 8.6 and any Co-Promotion Agreement(s)); 

  
 31 

 (iii) the Parties will participate in profits or losses arising from the
Commercialization of such Collaboration Products, all as detailed and pursuant to Section 9; and 
 (iv) each Party
will grant appropriate cross-licenses to the other Party to Research, Develop, Manufacture and Commercialize such Collaboration Products pursuant to Section 10. 

(g) [***]. 

(i) During the SAV Research Term, the Parties may review and discuss the available Clinical Data that is generated in the
course of Developing Collaboration PCV Products to determine whether [***]. 
 (1) If, during the SAV Research Term, [***],
then the Parties may mutually agree to amend the applicable Plan to [***] in accordance with the Plan for such SAV Program. 

(2) If, during the SAV Research Term, [***], and the Parties wish to conduct Collaboration Activities for such [***], then the
Parties may mutually agree to initiate a new SAV Program with respect to such [***] in accordance with Section 3.1(c). 

(3) [***] 

(ii) From time to time after the end of the SAV Research Term and during any remaining portion of the Collaboration Term for
the PCV Program, the Parties may review and discuss the available Clinical Data that is generated in the course of Developing Collaboration PCV Products to determine whether [***]. During the discussion referenced above, a Party shall disclose to
the other Party if such Party (or any of its Affiliates) is engaged in a pre-existing bona fide active and sustained research, development or commercialization program (alone or with one or more Third
Parties) on any [***] based on [***]. 
 (1) If, after the end of the SAV Research Term and during any remaining portion of
the Collaboration Term for the PCV Program, a pre-existing bona fide active and sustained research, development or commercialization program with respect to an [***] based on [***], then following the
disclosure pursuant to clauses (ii) above in which the existence of such pre-existing program became known to both Parties, each Party shall [***]. 

(2) If, after the end of the SAV Research Term and during any remaining portion of the Collaboration Term for the PCV Program,
such [***], then the Parties may mutually agree to amend the applicable Plan to incorporate the Research, Development, Manufacture and Commercialization of [***] associated with [***] in accordance with the Plan for such [***]. 

(3) If, after the end of the SAV Research Term and during any remaining portion of the Collaboration Term for the PCV Program,
no such pre-existing program exists [***], at the written request of either Party, then any [***]s based on any such [***] shall automatically be treated [***], for so long as one or both of the Parties [***].

  
 32 

 (iii) For the avoidance of doubt, subject to this Section 2.1(g) and
Sections 10.7 and 10.8, nothing in this Agreement shall limit either Party’s (or its Affiliates’) ability to research, develop, manufacture or commercialize any [***], or grant licenses or otherwise enter into agreements with one or more
Third Parties for any of those activities. 
 2.2 Collaboration Management. Promptly after the Effective Date, each
Party will appoint a person who will oversee day-to-day contact between the Parties for all matters related to the management of the Collaboration Activities in between
meetings of the Committees and will have such other responsibilities as the Parties may agree in writing after the Effective Date. One person will be designated by Merck (the “Merck Program Director”) and one person will be
designated by Moderna (the “Moderna Program Director”) and together they will be the “Program Directors”. Each Party may replace its Program Director at any time by notice in writing to the other Party. Any
Program Director may designate a substitute to temporarily perform the functions of that Program Director by written notice to the other Party. Each Program Director also may serve as a representative of its respective Party on one or more
Committees. The initial Program Directors will be: 
 For Moderna: [***] 

For Merck: [***] 

2.3 POC Committee. 

(a) Formation and Membership. Pursuant to the Original Agreement, the Parties have established a joint committee to
oversee the POC Programs (the “POC Committee”), comprised of [***] representatives of Moderna (or its Affiliate) and [***] representatives of Merck (or its Affiliate). Each POC Committee member will be a senior development leader or
have similar experience and expertise as a senior development leader. Each Party may replace its representatives on the POC Committee at any time upon written notice to the other Party. With the consent of the other Party (such consent not to be
unreasonably withheld, delayed or conditioned), each Party may invite non-voting employees and consultants to attend meetings of the POC Committee, subject to their agreement to be bound to the same extent as
a permitted subcontractor under Section 10.4. 
 (b) Meetings. While in existence, the POC Committee will meet
[***] (or more frequently as may be determined by the POC Committee) and may hold meetings in person or by audio or video conference as determined by the POC Committee, but at a minimum, [***] of such meetings each Calendar Year will be in person
(which in-person meeting will be held at one of Moderna’s U.S. facilities, and the other held at Merck’s U.S. facilities). Meetings of the POC Committee will be effective only if at least [***]
representative of each Party is present or participating. Each Party will be responsible for all of its own expenses of participating in the meetings. The Parties will endeavor to schedule meetings of the POC Committee at least [***] months in
advance. The POC Committee will determine the POC Committee operating procedures, which shall in all cases be consistent with the terms of this Agreement, and will codify these operating procedures in the written minutes of the first meeting (or
subsequent meetings as such procedures are updated). The POC Committee will prepare and circulate a meeting agenda prior to each such meeting. For the purposes of this Section 2, “agenda” will include any relevant background
materials. The Parties will alternate in preparing written 

  
 33 

 
minutes of such meeting, and the preparing Party will circulate such minutes within [***] days after such meeting. The Parties will agree on the minutes of each meeting promptly, but in no event
later than the next meeting of the POC Committee. Each Party will designate one (1) of its [***] representatives who is empowered by such Party to make decisions regarding issues within the purview of the POC Committee as set forth below in
Section 2.3(c) to act as the co-chair of each POC Committee. The co-chairs will be responsible for overseeing the activities of its POC Committee members consistent
with the responsibilities set forth in Section 2.3(c). 
 (c) Responsibilities. The POC Committee will discuss
the Parties’ performance of Collaboration Activities under the Internal SAV Program Plans and POC Plans. The POC Committee may form project teams to oversee any
day-to-day activities necessary to execute the POC Plans. Without limiting the generality of the foregoing, within such scope, the POC Committee will have the following
responsibilities: 
 (i) discuss an ISP Party’s performance of any Internal SAV Program under an Internal SAV Program
Plan; 
 (ii) review each Party’s performance of Collaboration Activities under the POC Plans; 

(iii) review any proposed modifications or amendments to a given POC Plan (including the Data Sharing and Sample Testing
Schedule included therein); 
 (iv) review and discuss any Additional Moderna PCV POC Term Studies conducted in accordance
with Section 3.3(d); 
 (v) resolve any disputes related to the Additional Moderna PCV POC Term Study contemplated in
Section 3.3(d); 
 (vi) prioritize and oversee execution of specific activities to be performed under each POC Plan;

 (vii) review and discuss amendments to the KRAS Transition Plan (provided that any amendments to the KRAS Transition Plan
must be mutually agreed to by the Parties in writing) and oversee the activities to be performed for the transition of the KRAS Program (including transfer of the IND) under the POC Plan and KRAS Transition Plan for the KRAS Program; 

(viii) review data, reports or other information submitted by either Party with respect to Collaboration Activities under each
Internal SAV Program Plan or POC Plan; 
 (ix) review and discuss any actual or potential Safety Issue or Technical Failure;

 (x) review and discuss any Pre-GLP Tox Data Package for a given Internal SAV
Program; 

  
 34 

 (xi) review and discuss any SAV IND Data Package for a given Joint SAV Program;

 (xii) form such other subcommittees or project teams as the POC Committee may deem appropriate (including any project
teams to oversee the day-to-day activities necessary to execute the POC Plans) and oversee the activities of any subcommittees or project teams formed by the POC
Committee, including by receiving and reviewing reports and other information submitted by those subcommittees or project teams (if applicable); provided, that any such subcommittee or project team may make recommendations to the POC
Committee but may not be delegated POC Committee decision-making authority; 
 (xiii) [***]; 

(xiv) coordinate and oversee the Manufacturing activities under a POC Plan with respect to PCVs (including Collaboration PCV
Products) under the applicable Programs in the Territory, including CMC matters; 
 (xv) review and discuss Manufacturing
activities under a POC Plan with respect to SAVs (including Collaboration SAV Products) under the applicable Joint SAV Program in the Territory, including CMC matters; 

(xvi) discuss and resolve all disputes referred to the POC Committee by any subcommittee or project teams established by the
POC Committee; 
 (xvii) review proposed publications regarding the results of the Collaboration Activities proposed to be
published in accordance with Section 12.2; and 
 (xviii) attempt to resolve any disputes relating to this Agreement on
an informal basis. 
 (d) Decision-making. The [***] POC Committee representatives of each Party will collectively
have one (1) vote (i.e., all representatives of a Party vote as a single block). The POC Committee members will use diligent efforts to reach agreement on all matters. If, despite such efforts, agreement on a particular matter cannot be
reached by the POC Committee within [***] days after the POC Committee first considers such matter (or such shorter time as may be reasonable in the circumstances), then upon the written request of a Party, such matter will be referred to the
Executive Officers (or their designees, which designee is required to have decision-making authority on behalf of such Party), who will attempt in good faith to resolve such dispute by negotiation and consultation for a [***] day period following
receipt of such written notice. If, despite such efforts, agreement on a particular matter cannot be reached by the Executive Officers within such [***] day period, then with respect to the applicable POC Program (i) if such matter relates to
[***] such matter shall be determined by Moderna, in good faith and its sole discretion after due and reasonable consideration of Merck’s position, (ii) if such matter relates to [***], such matter shall be determined by Merck, in good
faith and its sole discretion after due and reasonable consideration of Moderna’s position [***] (iv) for any other matter, such matter shall be resolved in accordance with the provisions of Section 15.1(c); provided that the Amended
Anticipated PCV POC Budget (including any component thereof) may not be modified without the written consent of the Parties. 

  
 35 

 (e) POC Committee Term. The POC Committee will cease to exist upon the
later of (i) the expiration or termination of all Merck Participation Election Periods or (ii) the expiration of the SAV Research Term. 

2.4 Joint Steering Committee. Upon the first exercise of a Merck Participation Election, then within thirty
(30) days after the Merck Participation Election Date, the Parties will establish a joint steering committee (the “Joint Steering Committee” or “JSC”). During the Merck Participation Term for a given Program,
the JSC will oversee and facilitate Research activities under any Additional Research Program and the Development, Manufacturing and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) for such Program. For clarity, the JSC
will not have any responsibilities regarding, or oversight of, activities under the POC Plan for a given Program. 
 (a)
Composition of the Joint Steering Committee. The Joint Steering Committee shall be comprised of [***] representatives of Merck and [***] representatives of Moderna. Each Party may change its representatives to the Joint Steering Committee
from time to time in its sole discretion, effective upon notice to the other Party of such change. These representatives shall have appropriate technical credentials, experience and knowledge, and ongoing familiarity with the Collaboration
Activities. With the consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned), each Party may invite non-voting employees and consultants to attend meetings of the
Joint Steering Committee, subject to their agreement to be bound to the same extent as a permitted subcontractor under Section 10.4. The JSC may change its size from time to time by mutual consent of its members; provided that the JSC will
consist at all times of an equal number of representatives of each of Merck and Moderna. Each Party will designate one of its representatives who is empowered by such Party to make decisions regarding issues within the purview of the Joint Steering
Committee to act as the co-chair of the Joint Steering Committee. The co-chairs will be responsible for overseeing the activities of its Joint Steering Committee members
consistent with the responsibilities set forth in this Section 2.4. 
 (b) Function and Powers of the Joint Steering
Committee. During the Merck Participation Term for a given Program, the Joint Steering Committee shall have general strategic oversight of the Collaboration for such Program, and shall confer regarding the status of the Additional Research Plans
and the Development Plans and the Research, Development, Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) for such Program. Without limiting the generality of the foregoing, the JSC shall have the
following specific responsibilities during the Merck Participation Term for a given Program: 
 (i) review and discuss the
Joint Development Plan and Budget for such Program and all amendments thereto, and approve any such amendments for the Joint Development Plan and Budget for the PCV Program and annual budget updates for the Joint Development Plan and Budget for any
Program in accordance with Section 4.3(c)(ii), including to determine the resources and activities allocated by each Party thereto (which resources and activities will be set forth in the Joint Development Plan and Budget for such Program);

 (ii) review and approve the Development Transition Plan for such Program; 

  
 36 

 (iii) review and comment on any Independent Additional Study Development Plan
for such Program; 
 (iv) review and approve the Global Commercialization Plan, Global Commercialization Budget and global
Commercialization strategy for such Program pursuant to Section 8.3; 
 (v) [***]; 

(vi) review, discuss and coordinate the Parties’ scientific presentation and publication strategy relating to the
Collaboration Products in the Territory for such Program in accordance with Section 12.2; 
 (vii) [***] 

(viii) review and approve any Additional Research Program(s) for such Program proposed by either Party; 

(ix) oversee Research activities conducted pursuant to any Additional Research Plan for such Program; 

(x) review and discuss any actual or potential Safety Issue with respect to any Collaboration Product or any Other Component
used in a Combination Product; 
 (xi) provide guidance to the JDC, JMC or JCC and attempt to resolve issues for such
Program presented to it by any other Committee; and 
 (xii) perform such other functions as may be expressly delegated to
the JSC pursuant to this Agreement. 
 (c) Joint Steering Committee Decision-Making. Decisions of the Joint
Steering Committee shall be made unanimously with each Party having one (1) vote (i.e., all representatives of a Party must vote as a single block). The Joint Steering Committee members will use diligent efforts to reach agreement on all
matters. If, despite such efforts, agreement on a particular matter cannot be reached by the Joint Steering Committee within [***] days after the Joint Steering Committee first considers such matter (or such shorter time as may be reasonable in the
circumstances), then upon the written request of a Party, such matter will be referred to the Executive Officers (or their designees, which designee is required to have decision-making authority on behalf of such Party), who will attempt in good
faith to resolve such dispute by negotiation and consultation for a [***] day period following receipt of such written notice. If, despite such efforts, agreement on a particular matter cannot be reached by the Executive Officers within such [***]
day period, then the matter shall be resolved in accordance with the provisions of Section 15.1(c); provided, that: 

(i) [***], such matter shall be determined by Merck, in good faith and its sole discretion after due and reasonable
consideration of Moderna’s position; 

  
 37 

 (ii) [***], such matter shall be determined by Moderna, in good faith and its
sole discretion after due and reasonable consideration of Merck’s position; 
 (iii) [***], such matter shall be
determined by Merck, in good faith and its sole discretion after due and reasonable consideration of Moderna’s position; 

(iv) [***], then such matter shall be determined by Moderna, in good faith and its sole discretion after due and reasonable
consideration of Merck’s position; 
 (v) [***], such matter shall be determined by Merck, in good faith and its sole
discretion after due and reasonable consideration of Moderna’s position; provided, however, (A) decisions with respect to [***] shall be in accordance with [***] (B) with respect to the [***], Merck shall [***]; 

(vi) [***], such matter shall be determined by Merck, in good faith and its sole discretion after due and reasonable
consideration of Moderna’s position; and 
 (vii) the budget within a Joint Development Plan and Budget for the
applicable Program, Global Commercialization Budget or the budget within an Additional Research Plan may not be increased without the written consent of the Parties. 

(d) Joint Steering Committee Meetings. The Joint Steering Committee shall meet in accordance with a schedule established
by mutual written agreement of the Parties, but no less than [***] per Calendar Quarter, unless the Parties mutually agree in writing to a different frequency, with the location for such meetings alternating between Moderna and Merck facilities (or
such other location as may be determined unanimously by the Joint Steering Committee members). Alternatively, the Joint Steering Committee may meet by means of teleconference, videoconference or other similar communications equipment. Each Party
shall bear its own expenses related to the attendance of such meetings by its representatives. 
 (e) Joint Steering
Committee Agendas. The co-chairs of the Joint Steering Committee shall be responsible for distributing an agenda for each Joint Steering Committee meeting at least [***] days in advance of such meeting.
Each Party shall have the right to request that the chairs include any appropriate matter (i.e., additional topics) on the agenda, which requests shall be accommodated by the chairs. 

(f) Joint Steering Committee Minutes. The co-chairs shall be responsible for
generating and issuing reasonably detailed minutes of each Joint Steering Committee meeting that reflect material decisions made and action items identified at such meeting, and will circulate such minutes to the Joint Steering Committee
representatives of each Party for review within [***] days after such meeting. Any corrections or comments to such minutes must be provided to the co-chair within [***] days after the draft minutes are issued,
who shall then issue the approved (or, if no comments are provided within such [***] day period, deemed approved) minutes in final form to the Joint Steering Committee representatives of each Party. 

  
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 2.5 Joint Development Committee or JDC. Upon the first exercise of
a Merck Participation Election, then within [***] days after the Merck Participation Election Date, the Parties will establish a joint development committee (the “Joint Development Committee” or “JDC”).
During the Merck Participation Term for a given Program, the JDC will oversee the conduct of the Development of Collaboration Products. For clarity, the JDC will not have any responsibilities regarding, or oversight of, activities under the POC Plan
for a given Program. 
 (a) Composition of the JDC. The JDC shall comprise [***] representatives of Merck and
[***] representatives of Moderna. Each Party may change its representatives to the JDC from time to time in its sole discretion, effective upon notice to the other Party of such change. These representatives shall have expertise and operational
responsibilities for Development and/or registration of pharmaceutical products. With the consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned), each Party may invite
non-voting employees and consultants to attend meetings of the JDC, subject to their agreement to be bound to the same extent as a permitted subcontractor under Section 10.4. The JDC may change its size
from time to time by mutual consent of its members; provided that the JDC will consist at all times of an equal number of representatives of each of Merck and Moderna. The JDC shall be chaired by a representative of Merck. The chair shall have the
responsibilities set forth in Section 2.5(e), but shall have no additional powers or rights beyond those held by the other JDC representatives. 

(b) Function and Powers of the JDC. During the Merck Participation Term for a given Program, without limiting the
generality of this Section 2.5, the JDC shall oversee and facilitate the conduct of the Development of Collaboration Products during the Merck Participation Term for such Program, including to: 

(i) monitor and oversee the Development activities under the Development Plan, including timely sharing and discussion of any
material results or events relating to such Development activities and discussion of any anticipated cost overruns; 
 (ii)
oversee the conduct of and monitor progress of any Clinical Studies under the Joint Development Plan and Budget for such Program; 

(iii) decide whether and when to initiate or discontinue any Clinical Study under the Joint Development Plan and Budget for
such Program; 
 (iv) facilitate the flow of information between the Parties with respect to the Development of
Collaboration Products for such Program; 
 (v) discuss and review the overall strategy regarding Regulatory Approval of
Collaboration Products in the Territory for such Program; 
 (vi) provide a forum for discussion of any regulatory related
activities and maintenance of INDs or CTAs for Collaboration Products and initial Regulatory Approvals for Collaboration Products for such Program; 

(vii) review the Development Transition Plans for such Program; 

(viii) coordinate with the JMC regarding enrollment for Clinical Studies for Collaboration Products, including the forecast
for Manufacturing capacity and the applicable enrollment rate; 

  
 39 

 (ix) discuss any Additional Study(ies) proposed by either Party for such
Program; and 
 (x) until the formation of the JCC, discuss, when available to Merck, the applicable and relevant components
of the initial Global Commercialization Plan for such Program; provided that for clarity, the JDC will not oversee the Commercialization activities with respect to Collaboration Products, and such Commercialization activities shall be under the
purview of the JCC, as, and to the extent, applicable. 
 (c) Joint Development Committee Decision-Making. Decisions
of the Joint Development Committee shall be made unanimously with each Party having one vote (i.e., all representatives of a Party must vote as a single block). In the event that the Joint Development Committee cannot or does not, after good
faith efforts during a period of not more than [***] days, reach agreement on an issue that comes before the JDC and over which the JDC has oversight, then such matter shall be raised to the JSC for resolution in accordance with Section 2.4(c).

 (d) JDC Meetings. The JDC shall meet in accordance with a schedule established by mutual written agreement of the
Parties, but no less frequently than [***] per Calendar Quarter, with the location for such meetings alternating between Moderna and Merck facilities (or such other location as may be determined unanimously by the JDC members). Alternatively, the
JDC may meet by means of teleconference, videoconference or other similar communications equipment. Each Party shall bear its own expenses related to the attendance of such meetings by its representatives. 

(e) JDC Agendas. The chair of the JDC shall be responsible for distributing an agenda for each committee meeting at
least [***] days in advance of such meeting. Each Party shall have the right to request the chair to include any matter on the agenda, which requests shall be accommodated by the chair. 

(f) JDC Minutes. The chair shall be responsible for generating and issuing reasonably detailed minutes of each JDC
meeting, which shall include a summary of any actions agreed at the meeting and will circulate such minutes to the JDC representatives of each Party for review within [***] days after such meeting. Any corrections or comments to such minutes must be
provided to the chair within [***] days after the draft minutes are issued, who shall then issue the approved (or, if no comments are provided within such [***] day period, deemed approved) minutes in final form to the JDC representatives of each
Party. 
 2.6 Joint Manufacturing Committee or JMC. Upon the exercise of the Merck Participation Election for the
first Program, then within [***] days after the Merck Participation Election Date, subject to the oversight of, and without limiting the authority of, the Joint Steering Committee, the Parties will establish a committee to oversee and facilitate the
Manufacturing of Collaboration Products for the Programs. For clarity, the JMC will not have any responsibilities regarding, or oversight of, activities under the POC Plan for a given Program. 

  
 40 

 (a) Composition of the Joint Manufacturing Committee. The joint
manufacturing committee (the “Joint Manufacturing Committee” or “JMC”) shall comprise [***] representatives of Merck and [***] representatives of Moderna. Each Party may change its representatives to the JMC from
time to time in its sole discretion, effective upon notice to the other Party of such change. These representatives shall have appropriate technical credentials, experience and knowledge, and ongoing familiarity with Manufacturing activities. With
the consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned), each Party may invite non-voting employees and consultants to attend meetings of the JMC, subject to their
agreement to be bound to the same extent as a permitted subcontractor under Section 10.4. The JMC may change its size from time to time by mutual consent of its members; provided that the JMC will consist at all times of an equal number of
representatives of each of Merck and Moderna. The JMC shall be chaired by a representative of [***]. The chair shall have the responsibilities set forth in Section 2.6(e) but shall have no additional powers or rights beyond those held by other
JMC representatives. 
 (b) Function and Powers of the JMC. Without limiting the generality of this Section 2.6,
the JMC shall oversee and facilitate the Manufacturing of Collaboration Products for a Program during the Merck Participation Term for such Program, including to: 

(i) coordinate and oversee the Manufacturing activities under this Agreement with respect to Collaboration Products in the
Territory in accordance with any Supply Agreement (as applicable), including CMC matters; 
 (ii) discuss and coordinate
with the JDC to allocate appropriate amounts from the applicable budgets to Manufacturing activities; 
 (iii) [***] 

(iv) coordinate with the JDC regarding enrollment for Clinical Studies for Collaboration Products under the applicable
Programs, including [***] and the applicable enrollment rate; 
 (v) coordinate with the JCC regarding Manufacturing of
Collaboration Products under the applicable Programs for Commercialization, including [***]; 
 (vi) [***]; and 

(vii) discuss, coordinate and plan for Manufacturing technology transfers as set forth in Section 6.2(f), a Supply
Agreement, [***] (as applicable). 
 (c) Joint Manufacturing Committee Decision-Making. Decisions of the Joint
Manufacturing Committee shall be made unanimously with each Party having one vote (i.e., all representatives of a Party must vote as a single block). In the event that the Joint Manufacturing Committee cannot or does not, after good faith
efforts during a period of not more than [***] days, reach agreement on an issue that comes before the JMC and over which the JMC has oversight, then such matter shall be raised to the JSC for resolution in accordance with Section 2.4(c). 

(d) JMC Meetings. The JMC shall meet [***], or more frequently as the Parties may agree, in accordance with a schedule
established by mutual written agreement of the Parties, with the location for such meetings alternating between Moderna and Merck facilities (or such other location as may be determined unanimously by the JMC members). Alternatively, the JMC may
meet by means of teleconference, videoconference or other similar communications equipment. Each Party shall bear its own expenses related to the attendance of such meetings by its representatives. 

  
 41 

 (e) JMC Agendas. The chair of the JMC shall be responsible for
distributing an agenda for each JMC meeting at least [***] days in advance of such meeting. Each Party shall have the right to request the chair to include any appropriate matter on the agenda, which requests shall be accommodated by the chair. The
chair shall be responsible for generating and issuing minutes, in accordance with Section 2.6(f), of each JMC meeting, which shall include a summary of any actions agreed at the meeting. 

(f) JMC Minutes. The chair shall be responsible for generating and issuing reasonably detailed minutes of each JMC
meeting, which shall include a summary of any actions agreed at the meeting and will circulate such minutes to the JMC representatives of each Party for review within [***] days after such meeting. Any corrections or comments to such minutes must be
provided to the chair within [***] days after the draft minutes are issued, who shall then issue the approved (or, if no comments are provided within such [***] day period, deemed approved) minutes in final form to the JMC representatives of each
Party. 
 2.7 Joint Commercialization Committee or JCC. Upon the first exercise of a Merck Participation Election,
then within [***] days after the Merck Participation Election Date, subject to the oversight of, and without limiting the authority of, the Joint Steering Committee, the Parties hereby establish a joint commercialization committee (the
“Joint Commercialization Committee” or “JCC”). During the Merck Participation Term for a given Program, the JCC will oversee and facilitate the Commercialization of Collaboration Products for such Program as
follows: 
 (a) Composition of the JCC. The JCC shall comprise [***] representatives of Merck and [***]
representatives of Moderna. Each Party may change its representatives to the JCC from time to time in its sole discretion, effective upon notice to the other Party of such change. These representatives shall have appropriate technical credentials,
experience and knowledge, and ongoing familiarity with Commercialization activities. With the consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned), each Party may invite
non-voting employees and consultants to attend meetings of the JCC, subject to their agreement to be bound to the same extent as a permitted subcontractor under Section 10.4. The JCC may change its size
from time to time by mutual consent of its members; provided that the JCC will consist at all times of an equal number of representatives of each of Merck and Moderna. The JCC shall be chaired by a representative of [***]. The chair shall have the
responsibilities set forth in Section 2.7(e) but shall have no additional powers or rights beyond those held by other JCC representatives. 

(b) Function and Powers of the JCC. During the Merck Participation Term for a given Program, without limiting the
generality of this Section 2.7, the JCC shall have the following specific responsibilities for such Program: 
 (i)
review and comment on the global Commercialization strategy for such Program; 

  
 42 

 (ii) review and comment on the Global Commercialization Plan for such Program,
including the Global Commercialization Budget; 
 (iii) as necessary, periodically request a review of the overall
commercial strategy for such Program, and request Merck prepare and submit an updated global Commercialization strategy for such Program for review by the JCC; 

(iv) discuss the Commercialization activities under the Global Commercialization Plan for such Program; 

(v) facilitate the flow of information between the Parties with respect to the Commercialization of Collaboration Products for
such Program; 
 (vi) review and discuss strategies with respect to Medical Affairs and Pricing Matters for Collaboration
Products in the Territory for such Program to the extent not prohibited by applicable Law; and 
 (vii) [***], coordinating Co-Promotion in the U.S. in accordance with the terms and conditions of this Agreement and the Co-Promotion Agreement for such Program. 

(c) Joint Commercialization Committee Decision-Making. Decisions of the Joint Commercialization Committee shall
be made unanimously with each Party having one vote (i.e., all representatives of a Party must vote as a single block). In the event that the Joint Commercialization Committee cannot or does not, after good faith efforts during a period of
not more than [***] days, reach agreement on an issue that comes before the JCC and over which the JCC has oversight, then such matter shall be raised to the JSC for resolution in accordance with Section 2.4(c). 

(d) JCC Meetings. The JCC shall meet [***], provided that as of and after the beginning of the Calendar Year immediately
preceding the anticipated First Commercial Sale of a Collaboration Product, the JCC shall meet [***] per Calendar Quarter, or more frequently as the Parties may agree, in accordance with a schedule established by mutual written agreement of the
Parties, with the location for such meetings alternating between Moderna and Merck facilities (or such other location as may be determined unanimously by the JCC members). Alternatively, the JCC may meet by means of teleconference, videoconference
or other similar communications equipment. Each Party shall bear its own expenses related to the attendance of such meetings by its representatives. 

(e) JCC Agendas. The chair of the JCC shall be responsible for distributing an agenda for each JCC meeting at least
[***] days in advance of such meeting. Each Party shall have the right to request the chair to include any matter on the agenda, which requests shall be accommodated by the chair. 

(f) JCC Minutes. The chair shall be responsible for generating and issuing reasonably detailed minutes of each JCC
meeting, which shall include a summary of any actions agreed at the meeting, and will circulate such minutes to the JCC representatives of each Party for review within [***] days after such meeting. Any corrections or comments to such minutes must
be provided to the chair within [***] days after the draft minutes are issued, who shall then issue the approved (or, if no comments are provided within such [***] day period, deemed approved) minutes in final form to the JCC representatives of each
Party. 

  
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 2.8 Authority. Notwithstanding the foregoing, each Party will retain the
rights, powers and discretion granted to it under this Agreement and no such rights, powers, or discretion will be delegated to or vested in the applicable Committee unless such delegation or vesting of rights is expressly provided for in this
Agreement or the Parties expressly so agree in writing. No Committee will have the power to (a) amend, modify or waive compliance with this Agreement, (b) alter, increase or expand the Parties’ rights or obligations under this
Agreement beyond those explicitly set forth in this Agreement, (c) determine that a Party has fulfilled any obligations under this Agreement or that a Party has breached any obligation under this Agreement, (d) make a decision that is
expressly stated to require the Parties’ mutual agreement or a decision for which Merck or Moderna have final decision making authority, (e) change the Collaboration Activities in any manner that would alter the fundamental objectives of
the Collaboration Activities as described herein, or (f) impose additional costs or expenses on either Party beyond those explicitly set forth in this Agreement. Any dispute between the Parties regarding the issues set forth in this
Section 2.8 will be resolved pursuant to the procedures set forth in Section 15.1. 
 2.9 Interactions Between
the Committees and Personnel. The Parties recognize that each Party possesses an internal structure (including various committees, teams and review boards) that may be involved in administering such Party’s activities under this Agreement.
The JSC shall establish procedures to facilitate communications between the JSC and the relevant internal committee, team or board of each of the Parties in order to maximize the efficiency of the JSC and the performance of the Parties of their
respective obligations under this Agreement. 
 2.10 Amendment and Restatement. The Parties hereby agree and
acknowledge that this Agreement amends and restates the Original Agreement in its entirety and the Original Agreement is replaced with, and superseded by, this Agreement; provided that, for the avoidance of doubt, any activities conducted under the
Original Agreement shall be deemed to have been conducted under this Agreement. 
 3. PROGRAMS AND MERCK PARTICIPATION ELECTIONS 

3.1 Overview of Programs. 

(a) PCV POC Program. Subject to and in accordance with the terms of this Agreement, during the POC Term for the PCV
Program, Moderna will undertake Research and Development and such other activities as set forth in the POC Plan for the PCV Program with the goal of Researching and Developing PCVs (including Collaboration PCV Products) through the conduct of
preclinical studies and Clinical Studies with monotherapy PCVs (including Collaboration PCV Products) and Collaboration PCV Products in combination with Keytruda to create the POC Data Package for the PCV Program, all as more fully set forth in the
POC Plan for the PCV Program (the “PCV POC Program”). For clarity, as of the Amended Effective Date, Moderna consents to [***] in accordance with the POC Plan for the PCV Program; provided, however, that notwithstanding the
foregoing, [***]. 

  
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 (b) KRAS POC Program. Subject to and in accordance with the terms of this
Agreement and the KRAS Transition Plan, during the POC Term for the KRAS Program, the Parties will undertake Research and Development and such other activities as set forth in the POC Plan for the KRAS Program with the goal of Researching and
Developing SAVs (including Collaboration SAV Products) Directed against KRAS through the conduct of preclinical studies and Clinical Studies with monotherapy SAVs (including Collaboration SAV Products) Directed against KRAS and Collaboration SAV
Products in combination with Keytruda to create the POC Data Package for the KRAS Program, all as more fully set forth in the POC Plan for the KRAS Program (the “KRAS POC Program”). For clarity, (i) the Parties acknowledge and
agree that, as of the Amended Effective Date, [***], and (ii) Moderna consents to [***]. 
 (c) Other SAV
Programs. 
 (i) During the SAV Research Term, to the extent that either Party wishes to conduct Research and
Development for SAVs Directed against a Target (or multiple Targets), other than KRAS, that is not the subject of a then existing SAV Program, then such Party shall provide written notice to the other Party of each proposed Target(s) to be included
in a proposed SAV Program, which notice shall set forth [***] any Moderna Pre-Existing In-Licenses, Moderna New In-Licenses or
Merck In-Licenses, as applicable, relating to such proposed Target(s) (an “SAV Target Notice”). Notwithstanding the foregoing, an SAV Target Notice may not include [***]. 

(ii) If the Parties mutually agree in writing to the inclusion of a proposed Target(s), [***], then (A) each such Target
shall become an “SAV Target,” (B) the Parties shall conduct a “Joint SAV Program” for such SAV Target(s), and (C) the Parties shall promptly thereafter mutually prepare and approve in writing a POC Plan for a Joint SAV
Program for such SAV Target(s). Such POC Plan for such Joint SAV Program shall contain such other information as set forth in and be consistent with Section 3.3(b). For the avoidance of doubt, the Parties may agree to multiple separate POC
Plans for multiple Joint SAV Programs pursuant to this Section 3.1(c)(ii). 
 (iii) If the non-proposing Party does not approve the inclusion of a proposed Target in an SAV Target Notice, [***], it shall notify the proposing Party thereof in writing within [***] days of receipt of the applicable SAV
Target Notice. During the SAV Research Term, if Moderna [***] declines in writing to participate in a program for a Target(s) that is proposed by Merck pursuant to an SAV Target Notice pursuant to Section 3.1(c)(i), then Merck may elect, upon
written notice to Moderna within [***] after Moderna declines to participate in such program, to [***] (provided that [***]). 

(iv) During the POC Term for a given Joint SAV Program, subject to and in accordance with the terms of this Agreement, the
Parties will undertake Research and Development and such other activities as set forth in the applicable POC Plan for such Joint SAV Program (other than the KRAS Program, which is covered by the provisions of Section 3.1(b) above) with the goal
of Researching and Developing SAVs (including Collaboration SAV Products) Directed against such SAV Target under such POC Plan through the conduct of preclinical studies and Clinical Studies with [***] SAVs (including Collaboration SAV Products)
Directed against such SAV Target and, [***] (each, an “Other SAV POC Program”, and together with the KRAS POC Program, each an “SAV POC Program”). The PCV POC Program, KRAS POC Program and each Other SAV POC Program
shall each be referred to herein as a “POC Program”.  

  
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 (d) Internal SAV Programs. 

(i) During the SAV Research Term, if a non-proposing Party reasonably declines in
writing to participate in a program for a Target(s) that is proposed pursuant to an SAV Target Notice in accordance with Section 3.1(c)(iii), or fails to respond in writing to the proposing Party within [***] days of receipt of the applicable
SAV Target Notice, then the proposing Party may elect, in its sole discretion, to provide written notice, within [***] days after the date that the non-proposing Party declines in writing to participate (or
fails to respond, as applicable), to the non-proposing Party to conduct an Internal SAV Program for such proposed Target(s), and (A) upon the date of such written notice, the proposing Party shall conduct
an “Internal SAV Program” for such Target(s) and shall be the “ISP Party” for such Internal SAV Program, (B) the ISP Party shall promptly thereafter (and in any event within [***] days) prepare in writing and provide to the non-ISP Party an Internal SAV Program Plan for such Internal SAV Program consistent with the SAV Target Notice, with the goal of Researching SAVs Directed against such Target(s) under the Internal SAV Program Plan
through the selection of a Lead SAV Candidate, and (C) the Parties shall promptly discuss in good faith and agree upon the definition of [***] to be set forth in the Internal SAV Program Plan for such Internal SAV Program, [***]. 

(ii) The ISP Party for such Internal SAV Program, [***], will undertake Research and such other activities as set forth in the
applicable Internal SAV Program Plan for such Internal SAV Program to generate information to prepare the Pre-GLP Tox Data Package for such Internal SAV Program. If Merck is the ISP Party for such Merck
Internal SAV Program, Moderna will Manufacture and supply SAVs (including mRNA Constructs therefor) Directed against the applicable Target(s) for such Merck Internal SAV Program, all in accordance with the supply terms set forth in Exhibit N.
An ISP Party may terminate its Internal SAV Program for any reason upon [***] days written notice to the non-ISP Party. If an ISP Party does not actively conduct its Internal SAV Program [***], then the ISP
Party shall provide prompt written notice to the non-ISP Party of such discontinuation [***], and as of the date of such written notice, [***]. 

(iii) During the Internal SAV Program Term for a given Internal SAV Program, the Parties shall present and review, via the POC
Committee, the status of the Research activities for such Internal SAV Program and the data generated thereunder. Upon [***], the ISP Party will promptly (and in any event within [***] days) prepare and provide to the
non-ISP Party the Pre-GLP Tox Data Package for such Internal SAV Program. After the delivery of the Pre-GLP Tox Data Package and
for the remainder of the Internal SAV Program Term for such Internal SAV Program, the ISP Party shall, as reasonably requested by the non-ISP Party, meet with the
non-ISP Party to discuss such Pre-GLP Tox Data Package and any questions of the non-ISP Party with respect thereto, including
providing the non-ISP Party with certain additional information as the non-ISP Party may reasonably request to assist with interpretation of such Pre-GLP Tox Data Package. 

  
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 (iv) On an Internal SAV Program-by-Internal SAV Program basis, the ISP Party hereby grants to the non-ISP Party, during the Internal SAV Program Term for a given Internal SAV Program, the
exclusive right, exercisable at the non-ISP Party’s sole discretion in accordance with Section 3.1(d)(v) below, to elect to continue, in collaboration with the ISP Party, the Research, Development,
Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) for such Internal SAV Program (and the Target(s) thereunder) as a Joint SAV Program, and to exercise the licenses set forth in Section 10.1(a)(ii) or
10.2(a)(ii) (as applicable) with respect to such mRNA Cancer Vaccines (including Collaboration Products) for such Internal SAV Program as a Joint SAV Program, in each case, solely under the terms and conditions set forth in this Agreement (each such
election, a “Pre-GLP Tox Election”). During the Internal SAV Program Term for a given Moderna Internal SAV Program, Merck may terminate its Pre-GLP Tox
Election for such Moderna Internal SAV Program upon written notice to Moderna. In the event that Merck terminates its Pre-GLP Tox Election for a given Moderna Internal SAV Program, then the consequences set
forth in Section 3.1(d)(vi) shall apply with respect to such Moderna Internal SAV Program (mutatis mutandis); provided, however, [***]. 

(v) On an Internal SAV Program-by-Internal SAV
Program basis, the non-ISP Party may elect to exercise the Pre-GLP Tox Election for a given Internal SAV Program by delivering to the ISP Party written notice of such
exercise at any time during the Internal SAV Program Term for such Internal SAV Program (each, a “Pre-GLP Tox Election Notice”). Commencing on the
Pre-GLP Tox Election Date for a given Internal SAV Program, (A) each Target(s) for such Internal SAV Program shall become an “SAV Target”, (B) such Internal SAV Program shall be converted into a
“Joint SAV Program” and (C) the Parties shall engage in such Joint SAV Program for such SAV Target(s) in accordance with Section 3.1(c)(ii), including preparing a POC Plan for such Joint SAV Program as soon as reasonably
practicable (and in any event within [***] days) after such Pre-GLP Tox Election Date. 

(vi) For a given Moderna Internal SAV Program, if Moderna delivers a Pre-GLP Tox Data
Package for such Moderna Internal SAV Program and Merck does not exercise the Pre-GLP Tox Election for such Moderna Internal SAV Program during the Internal SAV Program Term, then, upon written notice
to Merck within [***] days after the Pre-GLP Tox Commitment Date for such Moderna Internal SAV Program, Moderna shall be entitled to [***], Development, Manufacturing and Commercialization program for the
Target(s) for such Moderna Internal SAV Program outside the Collaboration and without any further compensation to Merck, and (A) each such Target shall be deemed a Released Target and the Moderna Internal SAV Program shall be deemed
terminated for purposes of this Agreement, (B) the licenses set forth in Section 10.1(d) may not be exercised by Merck with respect to such Released Target(s) and (C) the exclusivity provisions set forth in Sections 10.7(c) and
10.8(b) shall terminate with respect to the Released Target(s) and the provisions set forth in Sections 10.7(d)(iv) and 10.8(c)(iv) shall terminate with respect to the Collaboration Shared Neoepitope(s) under such Moderna Internal SAV Program,
[***]. 
 (vii) For a given Merck Internal SAV Program, if Merck delivers a Pre-GLP
Tox Data Package for such Merck Internal SAV Program and Moderna does not exercise the Pre-GLP Tox Election for such Merck Internal SAV Program during the Internal SAV Program Term, then Merck may elect
upon written notice to Moderna within [***] days after the 

  
 47 

 
Pre-GLP Tox Commitment Date for such Merck Internal SAV Program to either (1) convert such Merck Internal SAV Program to a “Joint SAV
Program” and each such Target to an “SAV Target”; provided that (x) Merck will be [***]; provided, however, that at the request of Merck, the Parties will [***], or (2) terminate such Merck Internal SAV Program upon written
notice to Moderna, provided that if Merck elects to exercise its rights under this clause (2), then (A) each Target for such Merck Internal SAV Program [***], (B) the licenses set forth in [***], (C) in such case, [***]terminate with respect to
such Merck Internal SAV Program [***], (D) any outstanding purchase orders for mRNA Constructs to be delivered by Moderna to Merck in accordance with the supply terms set forth in Exhibit N will terminate with respect to such Merck Internal
SAV Program, and (E) Merck shall have no further rights under Exhibit J with respect to such Merck Internal SAV Program. 

(e) Clinical Studies Under a POC Plan for a Joint SAV Program. 

(i) Selection of Collaboration Products for IND Enabling Studies. 

(1) For any given Internal SAV Program that converts to a Joint SAV Program in accordance with Section 3.1(d), if either
Party has reasonably identified [***], then, at the request of such Party, the Parties, via the POC Committee, will discuss whether to conduct such activities. If the Parties mutually agree that the conduct of such additional pre-clinical Research activities is reasonably likely to [***], the Parties will amend the applicable POC Plan to include such Research activities and any [***] (the “Additional Converted Program Research
Activities”), and the Parties will reasonably agree as to which Party should conduct the Additional Converted Program Research Activities. If the Parties do not mutually agree to amend the POC Plan for such Joint SAV Program to include such
Additional Converted Program Research Activities during the [***] following the POC Committee’s discussion, then (A) [***] (B) a Party may, [***]. 

(2) During the POC Term for a given Joint SAV Program, the Parties shall discuss in good faith and mutually agree on the
specific SAV(s) under such Joint SAV Program that will be the subject of the IND-Enabling Studies under the POC Plan for such Joint SAV Program. As of the Amended Effective Date, the Parties acknowledge and
agree that (A) the IND-Enabling Studies for the KRAS Program have been completed [***], and (B) mRNA-5671 is a Collaboration SAV Product Directed against KRAS for the KRAS Program and will be the
subject of Clinical Studies under the POC Plan for the KRAS Program. 
 (ii) Clinical Studies. 

(1) (I) From time to time prior to the completion of the IND-Enabling Studies for a
given Joint SAV Program, the Parties may review, and may mutually agree to update, in good faith, the Clinical Initiation Criteria for such Joint SAV Program based on reasonable scientific rationale. Following completion of IND-Enabling Studies for a given Joint SAV Program, the Party that conducted such IND-Enabling Studies will promptly prepare and provide the other Party with the SAV IND Data
Package for such Joint SAV Program. Within [***] days after the date of delivery of the SAV IND Data Package for such Joint SAV Program, the POC Committee will review and discuss the SAV IND Data Package for such Joint SAV Program, including
determining if the Clinical Initiation Criteria has been met for such Joint SAV Program (provided if there is disagreement as to [***], such disagreement shall be referred to Section 15.1(c) for resolution (which the Parties agree shall be
conducted within [***] days or such other period of time as agreed to by the Parties)). 

  
 48 

 (II) Promptly (but in any event within [***] days following the determination as
to whether the Clinical Initiation Criteria has been met for such Joint SAV Program (regardless of whether or not the Clinical Initiation Criteria were met), the Parties shall meet to discuss if the Parties desire to continue to progress such Joint
SAV Program into Clinical Studies under the POC Plan. Subject to the provisions of this Section 3.1(e)(ii), the Parties must mutually agree to advance such Joint SAV Program into Clinical Studies under the POC Plan for such Joint SAV Program
prior to commencing the first Clinical Study under the POC Plan; provided, however [***]. If the Parties mutually agree to advance such Joint SAV Program into Clinical Studies, then Merck shall use Commercially Reasonable Efforts to file an IND or
CTA for such Program in accordance with the POC Plan as soon as reasonably practicable after the date of such agreement. 

(III) If, within [***] days following the meeting of the Parties pursuant to clause (II) above, the Parties do not
mutually agree to advance such Joint SAV Program into Clinical Studies under the current POC Plan for such Joint SAV Program, then the Parties may continue for a period of [***] days to discuss in good faith alternatives to continue the Research and
Development of SAVs (and Collaboration SAV Products) under such Joint SAV Program, which alternatives may include, if mutually agreed to by the Parties, [***]. If the Parties do not mutually agree to amendments to the then current POC Plan within
such [***] day period or such longer time as mutually agreed to by the Parties, then the matter shall be referred to Section 15.1(c) for resolution (which the Parties agree shall be conducted within [***]or such other period of time as agreed
to by the Parties). 
 (IV) Notwithstanding anything herein to the contrary, the Parties acknowledge and agree that this
Section 3.1(e)(ii) shall not apply to the KRAS Program. 
 (2) In the event that the Parties mutually agree in writing
not to advance a given Joint SAV Program into Clinical Studies under the POC Plan for such Joint SAV Program, then the POC Term for such Joint SAV Program shall terminate [***] days after the Parties’ decision in writing (which shall in any
event be within [***] days after the date of delivery of the SAV IND Data Package) not to commence Clinical Studies for such Joint SAV Program. 

(3) In the event that an SAV IND Data Package is delivered to Merck and Moderna wishes to advance a given SAV for a Joint SAV
Program under the POC Plan for such Joint SAV Program (as notified by Moderna to Merck in writing simultaneously with the delivery of the SAV IND Data Package), but Merck does not agree to advance such SAV into Clinical Studies under such POC Plan,
then (A) [***] (B) [***], in each case ((A) and (B)), [***] after Merck’s decision in writing not to commence Clinical Studies for such Joint SAV Program. In the event that Merck does not agree in writing to commence Clinical Studies for such
Joint SAV Program within [***]. 

  
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 (4) In the event that (A) an SAV IND Data Package is delivered to Merck,
(B) as part of the POC Committee discussion pursuant to Section 3.1(e)(ii), Merck wishes to advance a given SAV for a Joint SAV Program into Clinical Studies under the POC Plan for such Joint SAV Program, (C) as part of the POC
Committee discussion pursuant to Section 3.1(e)(ii), Moderna does not agree to advance such SAV into Clinical Studies under the POC Plan, and (D) Moderna determines in good faith that there is [***] and notifies Merck thereof during the
POC Committee discussion pursuant to Section 3.1(e)(ii), then [***] 
 (5) In the event that (A) an SAV IND Data
Package is delivered to Merck, (B) as part of the POC Committee discussion pursuant to Section 3.1(e)(ii), Merck wishes to advance a given Joint SAV Program into Clinical Studies under the POC Plan for such Joint SAV Program, (C) as
part of the POC Committee discussion pursuant to Section 3.1(e)(ii), Moderna does not agree to advance a given Joint SAV Program into Clinical Studies under the POC Plan for such Joint SAV Program, and (D) Moderna [***], then Merck may
[***] pursuant to this Section 3.1(e)(ii)(5), then the following shall apply:
 a. Merck shall [***] 

b. Moderna shall [***]; 

c. [***] 

d. [***] 

e. [***] 

Notwithstanding anything herein to the contrary, the Parties acknowledge and agree that this Section 3.1(e)(ii) shall not
apply to the KRAS Program. 
 (iii) Non-Commencement or Suspension of Clinical
Studies for Safety Issue under POC Plan for a Joint SAV Program by Lead Regulatory Party. Notwithstanding anything to the contrary herein or in the applicable POC Plan for a given SAV POC Program, if the Lead Regulatory Party reasonably believes
that there is a Safety Issue for such SAV POC Program, then the Lead Regulatory Party will immediately (and in any event within [***] Business Days after the date the Lead Regulatory Party determines there is a Safety Issue) provide written notice
to the other Party of such Safety Issue for such Program, following which [***]. In all cases, the Lead Regulatory Party shall have the right to cease or suspend the conduct of a given Clinical Study for a given SAV POC Program if the Lead
Regulatory Party reasonably believes there is a Safety Issue. 
 (iv) Suspension of SAV Program for Technical
Failure. For a given SAV Program, the Parties may suspend the conduct of activities under such SAV Program upon mutual written agreement that there is a Technical Failure with respect to the SAVs for such SAV Program, subject to the consequences
in Section 3.2(b). 
 3.2 POC Term. 

(a) Subject to this Agreement, unless (i) earlier terminated by mutual written agreement of the Parties, or
(ii) extended by mutual written agreement of the Parties, the term of the PCV POC Program will commence on the Effective Date and expire upon the earliest of [***] (“PCV POC Term”); [***]. 

  
 50 

 (b) Subject to this Agreement (including Section 3.2(c)), unless
(i) earlier terminated by mutual written agreement of the Parties, or (ii) extended by mutual written agreement of the Parties, the term of a given SAV POC Program will commence on the date of Initiation of such Joint SAV Program (provided
that for clarity, with respect to the KRAS Program, the term shall commence on the Amended Effective Date) and expire upon the earliest of [***] (each, an “SAV POC Term” for the applicable Joint SAV Program, and together with the
PCV POC Term, each, a “POC Term”). 
 (c) Notwithstanding anything to the contrary contained herein, in the
event that Merck delivers the Merck Participation Election Notice for a given Program in accordance with this Agreement, then the POC Term for such Program shall automatically continue until [***]. 

3.3 POC Plan. 

(a) Initial POC Plan. Each POC Program shall be conducted in accordance with a plan (and with respect to the PCV
Program, in accordance with a budget) that has been prepared and mutually agreed to by the Parties for such POC Program (each, a “POC Plan”). The amended POC Plan for the PCV Program, [***], is attached hereto as Exhibit A-1, and the POC Plan, [***], for the KRAS Program is attached hereto as Exhibit A-2. The initial POC Plan for each Joint SAV Program (other than the KRAS
Program) shall be prepared by the Parties in accordance with Sections 3.1(c) and 3.1(d)(iv). A given POC Plan may be amended or updated, to the extent applicable, pursuant to Section 3.3(c). For clarity, each POC Plan may, if applicable,
include a schedule for data sharing and sample testing (a “Data Sharing and Sample Testing Schedule”) for the applicable POC Program. In addition, Moderna will use Commercially Reasonable Efforts, at its sole cost and expense, to
conduct the experiments set forth on Exhibit A-3, unless otherwise agreed by the Parties in writing, and all Know-How conceived, discovered, developed or
otherwise made by or on behalf of a Party or any of its Affiliates or permitted subcontractors of any of the foregoing (solely or jointly by or on behalf of a Party or any of its Affiliates or permitted subcontractors of any of the foregoing) in the
course of performing such experiments shall be Moderna Background Know-How, and [***]. 

(b) Scope. Each POC Plan shall set forth [***]. Each POC Plan for a Joint SAV Program shall set forth the anticipated
tasks and responsibilities of each Party throughout the applicable POC Program, it being understood that, except as otherwise specifically set forth in such POC Plan, Moderna shall be responsible for
non-clinical activities and Manufacturing (including CMC development, with input from Merck) of SAVs (including Collaboration SAV Products) under such POC Plan, and supply of Moderna Agents for use in such
Clinical Studies under such POC Plan, and Merck will be responsible for the preparation and filing of INDs and CTAs for, and the conduct of, the Phase I Clinical Study and Phase II Clinical Study of Collaboration SAV Products and supply of Keytruda
and Merck Agents for use in such Clinical Studies under such POC Plan. The Parties generally anticipate that the POC Plan for a given POC Program may include the following activities for such POC Program: 

(i) [***] 

(ii) [***] 

  
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 (iii) [***] 

(iv) [***] 

(v) [***] 

(vi) [***] 

(vii) [***] 

(viii) [***] 

(ix) [***] 

(x) [***] 

(xi) [***] 

(c) Preparation and Amendment of a POC Plan. Each of Merck and Moderna will have the right to propose modifications or
amendments to a POC Plan; provided that any modifications or amendments to any POC Plan that are proposed by either Party will be subject to review by the POC Committee and written approval by the Parties [***]; provided that neither Party may
[***]. With respect to any amendment to the POC Plan for the PCV Program, such amendment shall also include a budget to the extent set forth in Section 3.4(g)(iii). [***] 

(d) Additional Moderna PCV POC Term Study. In addition to the Research and Development activities
set forth in the POC Plan for the PCV Program, following [***], for a given Collaboration PCV Product, based on [***] that is sufficient to enable the Parties to proceed to a Registrational Study for such Collaboration PCV Product, [***], until the
expiration of the Merck Participation Election Period for the PCV Program, Moderna shall be entitled to conduct a Registrational Study for such Collaboration PCV Product (the “Additional Moderna PCV POC Term Study”),
subject to the following terms and conditions: (i) Moderna shall [***]; (ii) Merck shall [***]; (iii) Moderna may not [***], (v) Merck shall have the right to [***], (vi) the performance of the Additional Moderna PCV POC Term Study shall not
[***], (vii) to the extent that there are any [***], (viii) if Merck exercises the Merck Participation Election for the PCV Program, then [***], (ix) if Merck does not exercise the Merck Participation Election for the PCV Program, then [***], and
(x) Moderna shall provide Merck [***]. 
 3.4 POC Program Performance. 

(a) Efforts. The Parties have agreed to engage in POC Programs on the terms and conditions set forth in this Agreement,
under the oversight of the POC Committee and in accordance with the applicable POC Plans. 
 (b) PCV Program. Unless
otherwise agreed to by the Parties or otherwise explicitly set forth in the POC Plan for the PCV Program, (i) Moderna will be responsible for performing and conducting the PCV Program in accordance with the POC Plan for the PCV Program
(including the Manufacture of PCVs (including Collaboration PCV Products), in 

  
 52 

 
accordance with Exhibit K, [***]), including [***], and for generating the POC Data Package for the PCV Program, and (ii) Merck shall be solely responsible for
Manufacturing and supplying all Keytruda necessary for any Clinical Studies involving Collaboration PCV Product(s) in combination with Keytruda, in accordance with the supply terms set forth on Exhibit K. 

(c) KRAS Program. 

(i) Unless otherwise agreed to by the Parties or otherwise explicitly set forth in the POC Plan for the KRAS Program,
(A) Moderna will be responsible for Manufacturing and supply of mRNA-5671 in accordance with Exhibit K, and (B) Merck shall be responsible for (x) after the KRAS Transition Date, the conduct of the Phase I Clinical Study and
Phase II Clinical Study for mRNA-5671, including [***], and (y) supply of Keytruda for use in such Clinical Studies under such POC Plan. 

(ii) KRAS Transition Plan. As of the Amended Effective Date, the initial written plan for the transition of Development
activities from Moderna to Merck for the KRAS Program (the “KRAS Transition Plan”) is set forth on Schedule 3.4(c)(ii). The KRAS Transition Plan may be reviewed by and amended by mutual written agreement of
the Parties. Each Party will use Commercially Reasonable Efforts to perform the obligations assigned to it under the KRAS Transition Plan in accordance with the timelines set forth therein. All costs and expenses incurred in connection with the
conduct of the KRAS Transition Plan shall be borne by the Party incurring such cost or expense. The date upon which activities set forth in the KRAS Transition Plan are complete shall be the “KRAS Transition Date”. 

(d) Other Joint SAV Programs. Unless otherwise agreed to by the Parties or otherwise explicitly set forth in the
applicable POC Plan, for any given Joint SAV Program (other than the KRAS Program), (i) Moderna shall be solely responsible for performing and conducting the activities assigned to Moderna for such Joint SAV Program in accordance with the applicable
POC Plan (including (A) [***]), and (ii) Merck shall be solely responsible for performing and conducting the activities assigned to Merck for such Joint SAV Program in accordance with the applicable POC Plan, including [***]. 

(e) Diligence. Each Party shall use its Commercially Reasonable Efforts to perform and conduct each POC Program in
accordance with the applicable POC Plan (including any applicable timelines set forth therein) and the terms of this Agreement and to achieve the goals and deliverables set forth in each POC Plan, including, for Moderna, [***]. Subject to the
foregoing and the terms and conditions of this Agreement (including compliance with the applicable POC Plan), each Party (and not the POC Committee) shall be responsible for managing its own Research and Development efforts within the scope of the
activities for a POC Program pursuant to the applicable POC Plan and making decisions with respect to its day-to-day conduct in support of such Research and Development
efforts. For clarity, to the extent the Parties do not agree to commence some or all of the Development activities involving [***], this Section 3.4(e) shall not apply to such Development activities involving [***]. 

(f) Personnel and Resources. Each Party shall dedicate to each POC Program appropriate resources and allocate personnel
with an appropriate level of education, experience and training in Researching and Developing mRNA Cancer Vaccines (including Collaboration Products) for such POC Program in order to perform its activities as part of the applicable POC Program
efficiently and expeditiously, which resources and personnel shall be consistent with the applicable POC Plan. 

  
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 (g) Costs for the POC Plan for the PCV Program. 

(i) Subject to Section 3.4(g)(iii) and Section 3(a) of Exhibit F, unless otherwise agreed to by the Parties
in writing, costs and expenses incurred in the conduct of the POC Plan for the PCV Program (including all POC Program Costs for the PCV Program) will be borne solely by Moderna; provided, however, that, subject to the remainder of this
Section 3.4(g), [***]: 
 (1) Up to [***] of the Initial PCV POC Program Funding Amount shall be allocated for
activities set forth under the [***], and in the event that the costs and expenses to be incurred in connection with the completion of the activities set forth in the [***] exceed the [***], then [***] shall be responsible for and directly cover any
excess costs or expenses up to [***]; provided, however, that (A) in the event that the costs and expenses to be incurred in connection with the completion of the activities set forth under the [***] are reasonably expected to exceed the amount
in the [***], then [***] may, at its sole discretion, elect to directly cover any such excess costs or expenses; provided that if [***] does not elect to provide for additional funding for activities set forth under the [***], the Parties shall use
good faith efforts to reach agreement on a reasonable solution with respect to such activities set forth under the [***], including the funding thereof and, if the Parties are unable to reach agreement, the [***]; and (B) in the event that the
costs and expenses incurred in connection with the completion of the activities set forth under the [***] are less than the [***], then any remaining amount will be [***]. If Merck exercises the Merck Participation Election for the PCV Program, then
as of the Merck Participation Election Date at Merck’s election, (i) [***] of any of the costs incurred by or on behalf of Moderna (or its Affiliates) under this Section 3.4(g)(i)(1) that are in excess of the [***] but less than the amount
set forth in the [***] will be (1) [***], or (2) [***]; provided that if Merck does not exercise the Merck Participation Election for the PCV Program, then [***]. 

(2) Up to [***] of the Initial PCV POC Program Funding Amount shall be allocated for all Collaboration Activities set forth
under the [***]; provided, however, that, in the event that the costs and expenses to be incurred in connection with the performance of such Collaboration Activities under the [***], [***] shall be solely responsible for and cover any excess costs
or expenses up to the amount in the [***]. In the event that the costs and expenses to be incurred in connection with the performance of such Collaboration Activities are reasonably expected to exceed [***], [***] may, at its sole discretion, elect
to directly cover any such excess costs or expenses, and [***] shall continue to [***]; provided, further, that if [***] does not elect to provide for additional funding for such Collaboration Activities, the Parties shall use good faith efforts to
reach agreement on a reasonable solution with respect to such Collaboration Activities, including the funding thereof and, if the Parties are unable to reach agreement, the [***]. If Merck exercises the Merck Participation Election for the PCV
Program, then as of the Merck Participation Election Date at Merck’s election, (i) [***] of any of the costs incurred by or on behalf of Moderna (or its Affiliates) under this Section 3.4(g)(i)(2) that are in excess of the [***] but less
than the amount set forth in the [***] will be (1) [***], or (2) [***]; provided that if Merck does not exercise the Merck Participation Election for the PCV Program, then [***]. 

  
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 (3) Up to [***] of the Initial PCV POC Program Funding Amount may be allocated
for [***] solely to the extent the costs and expenses of the Collaboration Activities set forth in the POC Plan for the PCV Program attached hereto as of the Amended Effective Date [***] are less than [***]. With respect to such difference up to the
[***], the Parties will endeavor to agree in good faith on [***]. However, if the Parties are unable to so agree, then, in accordance with Section 3.3(c), [***]. 

(ii) Subject to Section 3.4(g)(iii) and Section 3(a) of Exhibit F, unless otherwise agreed to by the Parties
in writing, costs and expenses incurred in the conduct of the portion of the POC Plan for the PCV Program involving [***] will be borne solely by [***]; provided that, once the Parties mutually agree to commence Development activities involving the
[***] under the PCV POC Program, in the event that there are any amounts from the [***] that have not been used or allocated for use in accordance with the POC Plan for the PCV Program, the costs and expenses of such activities shall be funded from
such remaining amounts; subject to the following: 
 (1) Up to [***] of the [***] shall be allocated for Collaboration
Activities set forth under the amended POC Plan for the PCV Program (as attached hereto as of the Amended Effective Date) for the portion of the PCV Program involving [***]; provided, however, that, in the event that the costs and expenses to be
incurred in connection with the performance of such Collaboration Activities are reasonably expected to exceed the [***], [***] may, at its sole discretion, elect to directly cover any such excess costs or expenses, and [***] shall continue to
[***]; provided, further, that if [***] for such Collaboration Activities, the Parties shall use good faith efforts to reach agreement on a reasonable solution with respect to such Collaboration Activities, including the funding thereof and, if the
Parties are unable to reach agreement, [***]. 
 (iii) In the event that the Parties mutually agree in writing to amend the
POC Plan for the PCV Program for additional activities [***], as part of the amendment to the POC Plan for the PCV Program, the Parties shall also mutually agree in writing on a budget for the conduct of such activities. With respect to such
activities, the Parties shall [***]; provided that, with respect to activities related to the [***] shall be responsible for all costs and expenses for such activities up to the [***]. Notwithstanding the foregoing, in the event that there are
amounts from the [***], as applicable, that have not been used or allocated for use in accordance with the POC Plan for the PCV Program, then prior to the Parties [***], the costs and expenses of such activities shall be funded from the remaining
portions of the [***], as applicable. 
 Notwithstanding anything to the contrary contained herein, unless otherwise agreed
to by the Parties in writing, [***] shall be solely responsible for any and all costs and expenses relating to Research involving the [***] and none of such costs or expenses shall count against the [***]. 

  
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 (h) Costs for the POC Plans for the Joint SAV Programs. 

(i) Subject to Section 3(a) of Exhibit F, Section 3.1(e)(ii)(5) and this Section 3.4(h), unless
otherwise agreed to by the Parties in writing, each Party shall bear and be responsible for the costs and expenses incurred by or on behalf of such Party (or its Affiliates) in the conduct of each POC Plan for the applicable Joint SAV Program. 

(ii) For any Merck Internal SAV Program that converts into a Joint SAV Program in accordance with Section 3.1(d)(v), and
for which Moderna conducts IND-Enabling Studies and Merck subsequently initiates a Clinical Study for a Collaboration SAV Product for such Joint SAV Program, then within [***] days after [***]. 

(iii) For any Merck Internal SAV Program that converts into a Joint SAV Program in accordance with Section 3.1(d)(vii),
if Merck subsequently exercises the Merck Participation Election for such Joint SAV Program, then an amount equal to [***] of the amount of the costs that are incurred by or on behalf of Merck [***] shall be [***]. 

(i) Records. Each Party will maintain, or cause to be maintained, records of its activities under each POC Program in
sufficient detail and in good scientific manner appropriate for scientific, Patent and regulatory purposes, that will properly reflect all work performed therein, for a period consistent with such Party’s record retention policies, but in no
event less than required by applicable Laws. Subject to Section 6.1(e), each Party will have the right to reasonably request a copy of the other Party’s records for the applicable POC Program upon providing reasonable rationale for needing
such records. 
 (j) Reports. Each Party shall provide to the POC Committee reasonable progress updates at each
Calendar Quarter meeting of the POC Committee on the status of the POC Program activities conducted by such Party, including [***]. For clarity, all such reports shall be considered Confidential Information of both Parties. Each Party agrees that it
will also provide updates from time to time between such meetings as the other Party may reasonably request. 
 (k)
Regulatory Matters. For a given POC Program, during the applicable POC Term: 
 (i) The POC Lead Regulatory Party
shall be primarily responsible for regulatory matters with respect to the Collaboration Products in connection with the performance of the applicable POC Program. The POC Lead Regulatory Party shall ensure that all directions from any Regulatory
Authority, ethics committees or institutional review boards with jurisdiction over any Clinical Studies are followed. Further, the POC Lead Regulatory Party shall ensure that all necessary approvals, licenses, registrations or authorizations
(including any IND or CTA) from any Regulatory Authority, ethics committees or institutional review boards with jurisdiction over the Clinical Study are obtained prior to initiating performance of such Clinical Study. 

(ii) Subject to POC Committee oversight on the overall regulatory strategy for the Collaboration Products, including oversight
of the initial IND or CTA filings for a given Collaboration Product, the POC Lead Regulatory Party shall have primary responsibility with respect to submitting Regulatory Filings for the applicable Collaboration Products (other than DMFs) and all
communications with, and submissions to, Regulatory Authorities in connection with such Collaboration Products, with the other Party’s support and input, which 

  
 56 

 
support shall be provided by the other Party upon reasonable request by the POC Lead Regulatory Party [***]. The POC Lead Regulatory Party shall also be responsible for all routine maintenance of
all INDs or CTAs (other than DMFs) for the applicable Collaboration Products. Without limiting the foregoing, Moderna shall provide such information and assistance as Merck may reasonably request in connection with the completion of and submission
of, and maintenance of, Regulatory Filings (other than DMFs), including INDs and CTAs, and responses to inquiries from Regulatory Authorities, provided that (A) to the extent Moderna CMC Information is [***] or (B) in the event disclosure
of Moderna CMC Information [***], Merck will notify Moderna [***], provided further that in the event that the Parties are unable to agree [***], then such matter shall be referred to the Executive Officers (or their designees), and if the Executive
Officers (or their designees) are unable to agree on such course of action within such time frame, then [***]. In the event additional Moderna CMC Information not currently contained within regulatory documents [***], the Parties shall mutually
agree [***]. Moderna will be reasonable [***]. 
 (iii) If Moderna is the POC Lead Regulatory Party for any Clinical Studies
involving Keytruda, Moderna shall act as the sponsor of such Clinical Study under its existing IND or CTA for the applicable Collaboration Product and have a Right of Reference to the IND or CTA of Keytruda; provided, however, that in no event shall
Moderna file an additional IND or CTA for any Clinical Study involving Keytruda unless required by Regulatory Authorities to do so. If a Regulatory Authority requests an additional IND or CTA for a Clinical Study involving Keytruda, the Parties
shall meet and mutually agree on an approach to address such requirement. Merck shall provide reasonable support and input to enable Moderna to prepare and file an amendment solely to the extent required. 

(iv) The POC Lead Regulatory Party shall, subject to applicable Law, (1) allow subject matter experts from the other
Party to [***], (2) through the POC Committee, allow the other Party a reasonable opportunity to review and comment upon all material Regulatory Filings (other than DMFs or portions of such Regulatory Filings containing Moderna CMC Information) to
Regulatory Authorities for the applicable Collaboration Products, and the POC Lead Regulatory Party [***], (3) [***], and (4) promptly provide to individuals in the other Party’s regulatory group copies of any material correspondence or
other documents received from Regulatory Authorities with respect to the applicable Collaboration Products. In all cases, Merck shall have the right (but not the obligation) to participate in any discussions with a Regulatory Authority regarding
matters related to Keytruda or any Merck Agent. In all cases, Moderna shall have the right (but not the obligation) to participate in any discussions with a Regulatory Authority regarding matters related to [***]. 

(v) If Moderna is the POC Lead Regulatory Party for any Clinical Studies involving Keytruda, Merck shall provide to Moderna,
as necessary, a cross-reference letter or similar communication to the applicable Regulatory Authority to effectuate the Right of Reference for Keytruda. Notwithstanding anything to the contrary in this Agreement, neither Party shall have any right
to access the other Party’s CMC data with respect to a Moderna Agent, Merck Agent or Keytruda, as applicable. Merck shall authorize the FDA and other applicable Regulatory Authorities to cross-reference the applicable Merck INDs and CTAs for
Keytruda to provide data access to Moderna sufficient to support conduct of any Clinical Study sponsored by Moderna involving Keytruda. If Merck’s IND or CTA is not available in a given country, Merck will file its CMC data with the applicable
Regulatory Authority for such country, referencing Moderna’s IND or CTA as appropriate (however, Moderna shall have no right to directly access the CMC data for Keytruda). 

  
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 (vi) If Moderna is the POC Lead Regulatory Party for any Clinical Studies
involving Keytruda, Moderna shall (a) track and collect financial disclosure information from all “clinical investigators” involved in any Clinical Studies involving Keytruda and (b) prepare and submit the certification or
disclosure of the same in accordance with all applicable Law, including Part 54 of Title 21 of the United States Code of Federal Regulations (Financial Disclosure by Clinical Investigators) and related FDA Guidance Documents. Prior to the initiation
of clinical activities under any Clinical Study sponsored by Moderna involving Keytruda, the Parties shall determine, in writing, whether Moderna shall track and collect separate certification or disclosure forms for each of Merck and Moderna or one
(1) “combined” certification or disclosure form for both Merck and Moderna. For purposes of this Section 3.4(k)(vi), the term “clinical investigators” shall have the meaning set forth in Part 54.2(d) of Title 21 of the
United States Code of Federal Regulations. 
 (vii) With respect to any annual reporting period in which Moderna is not an
entity that is required to make a Transparency Report under applicable Law, Moderna will: (a) notify Merck, in writing, within [***] days after the commencement of such reporting period that Moderna is not so required; and (b) during such
reporting period Moderna will track and provide to Merck data regarding “indirect” payments or other transfers of value by Moderna to such health care professionals to the extent such payments or other transfers of value were required,
instructed, directed or otherwise caused by Merck pursuant to this Agreement in the format requested by Merck and provided on a basis to be agreed upon by both Parties. Moderna represents and warrants that any data provided by Moderna to Merck
pursuant to part (b) above will be complete and accurate to the best of Moderna’s knowledge. With respect to any such annual reporting period in which Moderna is required to make a Transparency Report under applicable Law, Moderna will
provide to Merck, in writing, Moderna’s point of contact for purposes of receiving information from Merck pursuant to this Section 3.4(k)(vii), along with such contact’s full name, email address, and telephone number. Moderna may
update such contact from time to time by notifying Merck in writing pursuant to Section 15.15. Where applicable, Merck will provide to such Moderna contact all information regarding [***] provided for use in a Clinical Study required for such
reporting. In the event that the [***] provided pursuant to this Section 3.4(k)(vii) changes, Merck shall notify Moderna of such revised value and the effective date thereof. For purposes of this Section 3.4(k)(vii), “Transparency
Report” means a transparency report in connection with reporting payments and other transfers of value made to health care professionals, including investigators, steering committee members, data monitoring committee members, and
consultants in connection with a Clinical Study in accordance with reporting requirements under applicable Law, including the Physician Payment Sunshine Act and state gift laws, and the European Federation of Pharmaceutical Industries and
Associations Disclosure Code, or a Party’s applicable policies. 
 (viii) Moderna shall be responsible for filing all
DMFs for Collaboration Products during the POC Term and in connection therewith the provisions of Section 7.2(b) shall apply mutatis mutandis. 

  
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 (l) Ownership of Regulatory Filings. 

(i) For a given POC Program, the POC Lead Regulatory Party or its Affiliates shall own, maintain, file and hold in its name,
all Regulatory Filings (other than DMFs), including INDs or CTAs, for the applicable Collaboration Products. The POC Lead Regulatory Party shall provide the POC Committee with regular updates regarding the status of Regulatory Filings and
correspondences for the applicable Collaboration Products, and such Regulatory Filings and correspondences shall be reviewed by the POC Committee. If Merck pays the Participation Election Payment for a given Program, Moderna shall assign and
transfer ownership of all relevant INDs or CTAs and Regulatory Filings (other than DMFs) then held by Moderna (or any of its Affiliates) for Collaboration Products for such Program to Merck in accordance with Section 4.3(b). 

(ii) The Parties agree and acknowledge that Moderna has filed an IND for a Clinical Study for mRNA-5671 under the KRAS Program
prior to the Amended Effective Date, and such IND shall be transferred to Merck in accordance with the KRAS Transition Plan. Notwithstanding the foregoing, in all cases, [***]. 

(1) In addition to the provisions of Section 12 and other provisions of this Agreement regarding treatment of Moderna CMC
Information, Merck recognizes that maintaining the confidentiality of [***], requires a higher level of vigilance than certain other Confidential Information, and agrees to (x) maintain in confidence the [***] with the same degree of care that
Merck uses to protect its own like sensitive information and (y) without limiting Section 3.4(k)(ii), strictly limit the use and disclosure of any such [***] solely for the purpose of preparing, filing and maintaining Regulatory Filings
and maintaining Regulatory Approvals and related quality purposes with respect to the applicable Collaboration Product and no other purpose.

(m) Adverse Event Reporting. For a given POC Program, during the applicable POC Term, the POC Lead Regulatory Party
shall be responsible for maintaining the global safety database for the Collaboration Products from such POC Program and reporting all Adverse Events related to the clinical activities under such POC Program to the appropriate Regulatory Authorities
in the countries in which the applicable Collaboration Products are being Developed, in accordance with the applicable Laws of the relevant countries and Regulatory Authorities. Without limiting the foregoing, upon the other Party’s request,
and for the PCV Program if Merck exercises the Merck Participation Election for the PCV Program, in all cases prior to IND/CTA transfer, the POC Lead Regulatory Party shall provide copies of any Serious Adverse Event and applicable non-serious Adverse Event reports with respect to any Collaboration Products from such Program and any details related thereto in accordance with Section 4.3(b)(ii). Within [***] days prior to the Commencement
of any Clinical Studies for any Collaboration Products during the applicable POC Term, the Parties will execute a pharmacovigilance agreement or update to the current pharmacovigilance agreement (“POC Pharmacovigilance Agreement”)
to ensure the exchange of relevant safety data within appropriate timeframes and in an appropriate format to enable the Parties to fulfill local and international regulatory reporting obligations and to facilitate appropriate safety reviews. The POC
Pharmacovigilance Agreement will include [***]. Such guidelines and procedures shall be in accordance with, and enable the Parties and their respective Affiliates to fulfill, local and international regulatory reporting obligations to Regulatory
Authorities. [***] 

  
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 (i) [***] 

(ii) [***] 

(n) Sample Testing. 

(i) For the PCV Program, Moderna shall provide samples of biological material collected from subjects participating in a
Clinical Study performed under the POC Plan for the PCV Program, including blood and/or tissue samples, to Merck as specified in the applicable protocol or as agreed to by the POC Committee. 

(ii) For a given Program, the Parties shall conduct testing on such samples in accordance with the Data Sharing and Sample
Testing Schedule (if set forth in the applicable POC Plan) and the applicable protocol. Solely to the extent intended to be shared between the Parties, as specified on the Data Sharing and Sample Testing Schedule in the applicable POC Plan, the
Party conducting the sample testing shall provide to the other Party the results of such sample testing in electronic form, or other mutually agreeable alternate form, on the timelines specified in the Data Sharing and Sample Testing Schedule or as
otherwise mutually agreed. [***] 
 3.5 Merck Participation Election Rights. 

(a) POC Data Package. Promptly following the expiration of the POC Term for a given SAV POC Program, Merck will provide
Moderna with the information listed in [***] of the definition of POC Data Package in Section 1.314 for such SAV POC Program that is generated by or on behalf of Merck or its Affiliates in the course of conducting Collaboration Activities for
such SAV POC Program. In addition, in no event more than [***] days following the earlier of (x) the completion of the Collaboration Activities set forth in the POC Plan for such POC Program and (y) the expiration of the POC Term for such
POC Program, Moderna shall provide the POC Data Package for such Program to Merck; provided, however, (A) to the extent Merck has [***] (B) with respect to the PCV Program, to the extent the Parties do not mutually agree to undertake
Development activities set forth in the POC Plan for the PCV Program involving the [***] pursuant to Section 3.1(a), Moderna shall not be required to include any information regarding [***] in the POC Data Package. After the delivery of the POC
Data Package and for the remainder of the Merck Participation Election Period for the applicable Program, Moderna shall, as reasonably requested by Merck, meet with Merck to discuss such POC Data Package and any questions of Merck with respect
thereto, including [***]. 
 (b) Grant of Merck Participation Election. On a Program-by-Program basis, Moderna hereby grants to Merck during the Merck Participation Election Period for a given Program the exclusive right, exercisable at Merck’s sole discretion, to continue, in
collaboration with Moderna, the Research, Development, Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) for such Program, and to exercise the licenses set forth in Section 10.1(c) with respect to such
mRNA Cancer Vaccines (including Collaboration Products) for such Program, in each case, solely under the terms and conditions set forth in this Agreement (each, a “Merck Participation Election”). 

  
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 (c) Merck Participation Election Period, Participation Election. On a Program-by-Program basis, Merck may elect to exercise the Merck Participation Election for a given Program by delivering to Moderna written notice of exercise at any time
during the Merck Participation Election Period for such Program (each, a “Merck Participation Election Notice”). Commencing on the Merck Participation Election Date for a given Program, the Parties shall engage in the Joint
Development Program for such Program in accordance with Section 4. For the avoidance of doubt, Merck may deliver the Merck Participation Election Notice for one or more Programs (or no Programs) at its discretion, and such determination may be
made by Merck on a Program-by-Program basis. 

(d) Net Residual Amount. Following the Merck Participation Election for the PCV Program, the Net Residual Amount (if
any) will be fully committed towards future Shared Collaboration Costs incurred by or on behalf of the Parties (or their Affiliates) during the Merck Participation Term for the PCV Program; provided, however, that notwithstanding the foregoing, if
Merck exercises the Merck Participation Election for the PCV Program prior to the completion of the activities set forth in the then-current POC Plan for the PCV Program, within [***] days after the Merck Participation Election Date for the PCV
Program, Moderna will provide Merck with [***] and, unless the Parties otherwise agree, such Net Residual Amount will be fully committed towards [***], and the remainder shall be fully committed towards future Shared Collaboration Costs for the PCV
Program incurred by or on behalf of the Parties (or their Affiliates) during the Merck Participation Term for the PCV Program. 

3.6 [***] Notwithstanding anything herein to the contrary, in the event that the [***] is incorporated [***] in a
given Program, the following terms and conditions of this Agreement as they apply to [***] as incorporated [***] for such Program will be modified as follows: 

(a) [***] 

(b) [***] 

(c) [***] 

(d) [***] 

(e) [***] 

(f) [***] 

(g) [***] 

(h) [***] 

(i) [***] 

(j) [***] 

  
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 (k) [***] 

(l) [***] 

(m) [***] 

(n) [***] 

3.7 Non-Exercise of Merck Participation Election. 

(a) Effects. For a given Program (other than for an Internal SAV Program), if: 

(i) Merck does not exercise the Merck Participation Election for such Program during the Merck Participation Election Period
for such Program; 
 (ii) [***] 

(iii) [***] 

(iv) [***], a “Merck Non-Participation”), then: 

(A) if for the PCV Program, the Merck Participation Election Period, the POC Term, the Collaboration Term and the
Collaboration shall terminate solely for the PCV Program, and all Collaboration PCV Products then in existence will be treated as “PCVs” under this Agreement thereafter (other than for purposes of this Section 3.7(a)); provided that
[***]; 
 (B) if for a Joint SAV Program, the Merck Participation Election Period, the POC Term, the Collaboration Term and
the Collaboration shall terminate solely for such Joint SAV Program and all Collaboration SAV Products then in existence from such Program will be treated as “SAVs” under this Agreement thereafter (other than for purposes of this
Section 3.7(a)); 
 (C) Merck shall no longer have any licenses or other rights under this Agreement (except [***]) to
Research, Develop, Manufacture and Commercialize any Collaboration Products from such Program under this Agreement; 
 (D)
Sections 10.7 and 10.8 shall terminate with respect to such Program [***]; 
 (E) (I) If Merck had initiated activities to
conduct a Clinical Study under the applicable Joint SAV Program, Merck will prepare and provide to Moderna [***]. 
 (II) If
Merck had Commenced a Clinical Study under the applicable Joint SAV Program [***]; 
 (F) [***]; 

(G) [***]; 

  
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 (H) Moderna will make the payments set forth in Section 9.2 and Exhibit
E in connection with (1) Moderna Net Profits allocated to sales of any Financial PCVs, or (2) Moderna Net Profits allocated to sales of any Financial SAVs up to an aggregate amount equal to [***]; 

(I) [***] 

(J) [***]; and 

(K) in all cases, if Moderna is conducting a Clinical Study involving Keytruda, the provisions of Section 3.4(m) shall
apply mutatis mutandis. For purposes of clause (H)(2) of this Section 3.7, within [***] after the date of the Merck Non-Participation for a given Joint SAV Program, Merck shall provide to Moderna
[***]. Additionally, in the event of a Merck Non-Participation for the PCV Program, then subject to the remainder of this Section 3.7, during [***] period following the effective date of the Merck Non-Participation for the PCV Program, [***]. 
 [***] 

In the event that Merck exercises the Merck Non-Participation with respect to a Joint SAV Program
before the date of [***], then (1) Merck shall, [***]. 
 In addition, the Parties’ rights and obligations under [***] shall
terminate in full with respect to such Program [***]. In addition, on a Program-by-Program basis, if, as of the date of the Merck
Non-Participation for such Program, a Party is granting a sublicense to the other Party under an Included In-License for such Program, and such sublicense under such
Included In-License survives the Merck Non-Participation for such Program pursuant to this Section 3.7(a), then, (i) the Party receiving such sublicense under
such Included In-License shall [***] and (ii) such Party’s rights under such Included In-License will be subject to the terms of such Included In-License; provided that in each case of (i) and (ii), the licensor Party promptly informs the other Party of any [***]. 

(b) Remaining Activities under the POC Plan for the PCV Program. If (i) Merck exercises the Merck Non-Participation for the PCV Program and (ii) the activities set forth in the then-current POC Plan for the PCV Program are not completed prior to the expiration or termination of the PCV POC Term, then
Moderna will retain the Net Residual Amount (if any) and will use the Net Residual Amount for the continued Research, Development, Manufacture or Commercialization of PCVs (including any Collaboration PCV Products then in existence). 

 

	4.	 ADDITIONAL RESEARCH PROGRAM AND JOINT DEVELOPMENT PROGRAM 

4.1 Overview. 

(a) General. If Merck exercises the Merck Participation Election for a given Program, during the Merck Participation
Term for such Program, the Parties shall mutually conduct a Research and Development program with the goal of furthering the Research and Development of mRNA Cancer Vaccines (including Collaboration Products) for such Program and conducting Clinical
Studies with the goal of obtaining Regulatory Approvals for one or more Collaboration Products for such Program all subject to and in accordance with this Agreement. 

  
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 (b) Additional Research Programs. During the Merck Participation Term for
a given Program, the Parties may conduct one or more Additional Research Programs focused on advancing the Research and Manufacturing of mRNA Cancer Vaccines (including Collaboration Products) for such Program, subject to and in accordance with the
terms of this Agreement and the applicable Additional Research Plan (each, an “Additional Research Program”). 

(c) Clinical Studies. 

(i) During the Merck Participation Term for a given Program, the Parties shall conduct Clinical Studies of Collaboration
Products from such Program either as a monotherapy or in combination with Other Components, including as a part of clinical development partnerships with Third Parties by either Party or its Affiliates, subject to and in compliance with this
Agreement (including the exclusivity provisions hereunder) and the applicable Joint Development Plan and Budget for the applicable Program (the “Joint Development Program” for such Program), as well as Independent Additional Studies
for such Program pursuant to Section 4.4 in compliance with this Agreement (including the exclusivity provisions hereunder). In all cases, the Merck Participation Term Lead Regulatory Party shall have the right to cease or suspend the conduct
of a given Clinical Study if the Merck Participation Term Lead Regulatory Party reasonably believes there is a Safety Issue. 

(ii) If the Merck Participation Term Lead Regulatory Party suspends the conduct of a Clinical Study for a given Joint SAV
Program as a result of a Safety Issue, then the Merck Participation Term Lead Regulatory Party shall provide immediate (and in any event within [***] Business Days of the determination by the Lead Regulatory Party of such Safety Issue) written
notice to the other Party of such determination, and the Parties will discuss in good faith whether to initiate a new Joint Development Plan and Budget to resolve the Safety Issue for such Joint SAV Program. If the Parties mutually agree upon a new
Joint Development Plan and Budget for such Joint SAV Program, then the Parties will perform the Collaboration Activities (including any nonclinical studies or Clinical Studies) under the new Joint Development Plan and Budget for such Joint SAV
Program in accordance with this Agreement. If the Merck Participation Term Lead Regulatory Party provides written notice of a Safety Issue for such Joint SAV Program, and as a result thereof the Parties do not recommence Collaboration Activities to
resolve the Safety Issue under such Joint Development Plan and Budget (or amended Joint Development Plan and Budget) for a period of [***], then upon the expiration of such [***] period, then Merck will be deemed to have exercised the Merck
Cessation Election for such Joint SAV Program pursuant to Section 10.10. For clarity, if Merck proposes a reasonable Joint Development Plan and Budget to resolve such Safety Issue within such [***] period, (A) Moderna shall [***] and
(B) the preparation and initiation of activities under such Joint Development Plan and Budget shall be deemed [***]. 

  
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 4.2 Additional Research Programs. 

(a) General. During the Merck Participation Term for a given Program, in the event that a Party proposes to conduct an
Additional Research Program for such Program, then such Party shall propose the Additional Research Program to the JSC and such Party will prepare an Additional Research Plan for such Additional Research Program, setting forth such activities and
budget therefor and, solely to the extent the Parties mutually agree and approve such Additional Research Plan, [***], the Parties shall conduct such Additional Research Program in accordance with the terms of this Agreement and such Additional
Research Plan. All costs and expenses incurred by or on behalf of the Parties (or their Affiliates) in connection with the conduct of any Additional Research Program(s) shall be considered Allowable Development Costs. The Parties acknowledge and
agree that Research activities under an Additional Research Plan may be [***]. 
 (b) Additional Research Plans.
Either Party may propose at any meeting of the JSC amendments to any Additional Research Plan. Notwithstanding the foregoing, at a minimum, no later than [***] days prior to the start of a given Calendar Year, the Parties shall propose an updated
budget for any ongoing studies or Manufacturing activities under any then-current Additional Research Plans for the Additional Research Programs for the upcoming Calendar Year for the JDC’s review and JSC’s approval. Additional Research
Plans that incorporate Manufacturing activities (e.g., process development) for Collaboration Products should also be presented to the JMC for review and comment. 

(c) Efforts. The Parties will conduct each Additional Research Program on the terms and conditions set forth in this
Agreement, under the oversight of the JDC, JSC, and JMC, as applicable, and in accordance with the applicable Additional Research Plan. Each Party shall use its respective Commercially Reasonable Efforts to perform the activities allocated to it
pursuant to the applicable Additional Research Plan for a given Additional Research Program in accordance with the terms of this Agreement and within the timelines set forth in such Additional Research Plan, and to achieve the goals and deliverables
set forth in such Additional Research Plan. Subject to the foregoing and the terms and conditions of this Agreement (including compliance with the applicable Additional Research Plan), each Party (and not the Joint Steering Committee) shall be
responsible for managing its own Research and Manufacturing efforts within the scope of the activities allocated to it pursuant to the applicable Additional Research Plan for a given Additional Research Program and for making decisions with respect
to its day-to-day conduct in support of such Research and Manufacturing efforts in connection therewith. 

4.3 Joint Development Program. 

(a) General. During the Merck Participation Term for a given Program, it is the expectation of the Parties that
(i) Merck will be the Party solely responsible for conducting the clinical Development activities for the Collaboration Products under the Joint Development Plan and Budget for the applicable Program, (ii) with respect to the PCV Program,
each Party will be solely responsible for conducting an Independent Additional Study proposed by such Party under the applicable Independent Additional Study Development Plan, (iii) with respect to a given Joint SAV Program, [***], (iv) subject
to Section 6.2, Moderna will be responsible for conducting Manufacturing activities, including [***], under the Joint Development Plan and Budget for the applicable Program, and (v) Merck will be primarily responsible for pre-approval Commercialization activities (all subject to Section 8), in each case, unless the Parties otherwise agree. 

  
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 (b) Development Transition Plan. Promptly following the Merck
Participation Election Date for a given Program, Moderna will prepare and provide to Merck a draft plan for the transition of any Development activities then being conducted by or on behalf of Moderna or its Affiliates from Moderna to Merck for such
Program (including with respect to the PCV Program, Clinical Studies for Collaboration PCV Products) (a “Development Transition Plan”), which Development Transition Plan will be reviewed by the JDC and subject to the approval of the
JSC. If and to the extent applicable, the Development Transition Plan will require Moderna to perform the following activities (provided that, for clarity, the Development Transition Plan shall not include any obligations for Moderna to provide to
Merck any information or materials previously provided to Merck or to re-perform any activities that have already been transitioned to Merck), on the timeline set forth in the Development Transition Plan: 

(i) transfer and assign to Merck or its designee [***]; 

(ii) transfer to Merck [***]; 

(iii) deliver to Merck copies of all [***]; 

(iv) (A) with respect to the PCV Program, to the extent it is determined pursuant to [***] that [***] should be [***], at
Merck’s request, reasonably assist Merck in [***] and (B) with respect to each Joint SAV Program, to the extent it is determined pursuant to [***] that [***] should be [***], at Merck’s request, reasonably assist Merck in [***]; and

 (v) deliver to Merck, in an electronic format (the form of which shall be agreed upon by the Parties), [***]. 

Each Party will use Commercially Reasonable Efforts to perform the obligations assigned to it under the Development Transition Plan in
accordance with the timelines set forth therein. All costs and expenses incurred by or on behalf of the Parties (or their Affiliates) in connection with the conduct of the Development Transition Plan shall be considered Allowable Development Costs.

 (c) Joint Development Plans. 

(i) Within (x) [***] days after the Merck Participation Election Date for the PCV Program, or (y) subject to the last
sentence of this Section 4.3(c)(i), [***] days after the date of the Merck Participation Election Notice for a given Joint SAV Program, the Parties shall agree on the Collaboration Activities of the Parties with respect to the applicable Joint
Development Program and set forth such activities and a [***] year rolling budget therefor (such budget to be on a study-by-study or activity-by-activity basis) in a joint development plan (each, a “Joint Development Plan and Budget”), the initial draft of which shall be prepared by [***]. The purpose of the Joint
Development Plan and Budget for the applicable Program is to set forth the specific Development activities to be performed by the Parties in support of such Joint Development Program, [***]. Each Joint Development Plan and Budget for the applicable
Program shall set forth activities that are similar in nature to those contained in the applicable POC Plan. Notwithstanding anything herein to the contrary, if the Parties fail to mutually agree on a Joint Development Plan and Budget for a given
Joint SAV Program within [***] days after 

  
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the date of the Merck Participation Election Notice for such Joint SAV Program, then Moderna shall deliver written notice (together with an invoice) to Merck that the SAV Participation Election
Payment for such Joint SAV Program is due and either (1) Merck may pay the SAV Participation Election Payment for such Joint SAV Program within [***] Business Days after receipt of such notice, and the Parties will continue to diligently work
to mutually agree on a Joint Development Plan and Budget for such Joint SAV Program, or (2) if Merck does not make such payment under clause (1), then [***]. 

(ii) Either Party may propose at any meeting of the JDC amendments to the Joint Development Plan and Budget for the applicable
Program; provided, however, if such amendments involve an Additional Study or series of related Additional Studies, the inclusion of such Additional Study(ies) shall be in accordance with Section 4.4. Notwithstanding the foregoing, at a
minimum, no later than [***] days prior to the start of a Calendar Year, the Parties shall propose an updated budget for any ongoing studies or activities under the then-current Joint Development Plan and Budget for the applicable Joint Development
Program for the upcoming Calendar Year for the JDC’s review and JSC’s approval.  

(iii) The Parties have agreed to engage in the Joint Development Programs on the terms and conditions set forth in this
Agreement, under the oversight of the JDC and JSC and in accordance with the applicable Development Plans. Each Party shall use its respective Commercially Reasonable Efforts to perform the activities allocated to it pursuant to the Development
Plans [***] in accordance with the terms of this Agreement and within the timelines set forth in the Development Plans and [***], respectively, and to achieve the goals and deliverables set forth in the Development Plans and [***], including [***].
Subject to the foregoing and the terms and conditions of this Agreement (including compliance with the Development Plans and [***] and any applicable Clinical Supply Agreement), each Party (and not the JSC) shall be responsible for managing its own
Development and Manufacturing efforts within the scope of the activities allocated to it pursuant to the Development Plans and [***] and for making decisions with respect to its
day-to-day conduct in support of such Development efforts. 

4.4 Additional Studies. 

(a) Proposal of Additional Studies. 

(i) To the extent that either Party wishes to conduct an Additional Study or related series of Additional Studies of a
Collaboration Product ([***]) that is not set forth in the Joint Development Plan and Budget for the applicable Program for the purpose of seeking Regulatory Approval for such Collaboration Product, such Party shall prepare a [***] year
rolling Development plan and budget for such Additional Study(ies) and propose such Additional Study(ies) to the JDC. Such proposed Development plan and budget shall identify the applicable Collaboration Product, [***] (an “Additional Study
Proposal”). Following receipt of the Additional Study Proposal from the proposing Party, the non-proposing Party shall have [***] days to decide whether or not to
co-fund such Additional Study, and if such non-proposing Party elects to so co-fund, then such Additional Study will be
considered a “Joint Development Study”, and the Parties shall amend and update the Joint Development Plan and Budget for the applicable Program to include such Additional Study as a Joint Development Study as part of the Joint
Development Program. 

  
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 (ii) If the non-proposing Party fails to
elect to co-fund a proposed Additional Study within such [***] day period, then (1) with respect to such proposed Additional Study for the PCV Program, [***] (2) with respect to a proposed Additional
Study for a Joint SAV Program, [***], may independently conduct such Additional Study (an “Independent Additional Study”) subject to the terms and conditions of this Section 4.4 and in accordance with such Additional Study
Proposal (thereafter, an “Independent Additional Study Development Plan”); provided, however, that if (A) the Independent Additional Study would involve a Collaboration Product in combination with a Moderna Agent when Moderna
is the non-proposing Party or a Merck Agent [***] when Merck is the non-proposing Party, then [***], or (B) the
non-proposing Party reasonably and in good faith believes that [***], then the proposing Party shall [***].

(b) Costs. The Party sponsoring or conducting an Independent Additional Study under an Independent Additional Study
Development Plan shall be responsible for [***], in connection with such Independent Additional Study(ies) and such costs shall be borne in accordance with this Section 4.4 and Exhibit D. 

(c) Recording of Costs. All Development Costs pursuant to this Section 4.4 shall be recorded and reported
consistent with Exhibit D. Each Party shall keep records associated with Development Costs incurred through performance of an Independent Additional Study Development Plan strictly separate from records associated with Development Costs
incurred through performance of the applicable Joint Development Program. 
 4.5 Records, Reports, Resources.

 (a) Personnel and Resources. Each Party shall dedicate to the Additional Research Programs, Joint Development
Programs and Independent Additional Studies (as applicable) appropriate resources and allocate personnel with an appropriate level of education, experience and training in Researching and Developing mRNA Cancer Vaccines (including Collaboration
Products) for such Programs in order to achieve the objectives of the Additional Research Programs, Joint Development Programs and Independent Additional Studies (as applicable) efficiently and expeditiously, which resources and personnel shall be
consistent with the Additional Research Plans or Development Plans (as applicable). 
 (b) Research and Development
Costs. Development Costs incurred in the conduct of the Additional Research Programs and Joint Development Programs will be borne in accordance with Exhibit D. Development Costs incurred in the conduct of the Independent Additional
Study Development Plan(s) (as applicable) will be borne in accordance with Exhibit D. 
 (c)
Records. Each Party will maintain, or cause to be maintained, records of its activities under the Additional Research Programs, Joint Development Programs and Independent Additional Studies (as applicable) in sufficient detail and in good
scientific manner appropriate for scientific, Patent and regulatory purposes, that will properly reflect all work performed therein, for a period consistent with such Party’s record retention policies, but in no event less than required by
applicable Laws. Each Party will have the right to reasonably request a copy of any such records upon providing reasonable rationale for needing such records; provided, however, Moderna shall have no right to directly access the CMC data for [***],
and Merck shall have no right to directly access the CMC data for [***]. 

  
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 (d) Reports. Each Party shall provide to the JDC a summary written report
at each Calendar Quarter meeting of the JDC, describing its progress under the Additional Research Plans or Development Plans (as applicable) during the prior Calendar Quarter, which summary report shall include [***]. Each Party agrees that it will
promptly respond to the other Party’s reasonable questions regarding any of the other Party’s reports. For clarity, all such reports shall be considered Confidential Information of each Party. Each Party shall also provide updates from
time –to -time between such meetings as the other Party may reasonably request. 
  

	5.	 COMPLIANCE 

5.1 General. Each Party shall conduct the Internal SAV Programs, POC Programs, Additional Research Programs, Joint
Development Programs and Independent Additional Studies and other activities under the Internal SAV Program Plans, POC Plans, Additional Research Plans, Joint Development Plan and Budget for the applicable Program or Independent Additional Study
Development Plans in compliance with all applicable Laws. Each Party shall promptly notify the other Party in writing of any deviations from applicable Laws, including, each if and to the extent applicable to the respective Party or its activities
hereunder, the Act, the Anti-Kickback Statute (42 U.S.C. §1320a-7b), Civil Monetary Penalty Statute (42 U.S.C. §1320a-7a), the False Claims Act (31 U.S.C.
§ 3729 et seq.), comparable state statutes, the regulations promulgated under all such statutes, and the regulations issued by the FDA. In addition, each Party hereby certifies that it has not employed or otherwise used in any capacity and will
not employ or otherwise use in any capacity, the services of any person debarred under United States law, including Section 21 USC 335a, or any foreign equivalent thereof, in performing any portion of the Internal SAV Programs, POC Programs,
Additional Research Programs, Joint Development Programs or Independent Additional Studies or other activities under the Internal SAV Program Plans, POC Plans, Additional Research Plans, Joint Development Plan and Budget for the applicable Program
or Independent Additional Study Development Plans. Each Party shall notify the other Party in writing immediately if any such debarment occurs or comes to its attention, and shall, with respect to any person or entity so debarred promptly remove
such person or entity from performing activities under the Internal SAV Programs, POC Programs, Additional Research Programs, Joint Development Program or Independent Additional Studies or other activities under the Internal SAV Program Plans, POC
Plans, Additional Research Plans, Joint Development Plan and Budget for the applicable Program or Independent Additional Study Development Plans, function or capacity related thereto. Without limiting the foregoing, if animals are used in Research
hereunder, the applicable Party will comply with the Animal Welfare Act and any other applicable Laws relating to the care and use of laboratory animals. Merck encourages Moderna to use the highest standards, such as those set forth in the Guide for
the Care and Use of Laboratory Animals (NRC, 1996), for the humane handling, care and treatment of such research animals. Any animals which are used in the course of the Internal SAV Programs, POC Programs, Additional Research Programs, Joint
Development Programs or Independent Additional Studies or other activities under the Internal SAV Program Plans, POC Plans, Additional Research Plans, Joint Development Plan and Budget for the applicable Program or Independent Additional Study
Development Plans, or products derived from those animals, such as eggs or milk, will not be used for food purposes, nor will these animals be used for commercial breeding purposes. 

  
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 5.2 Use of Human Materials. Without limiting the provisions of
Section 5.1, if any human cell lines, tissue, human clinical isolates or similar human-derived materials (“Human Materials”) are to be collected or used in the Internal SAV Programs, POC Programs, Additional Research Programs,
Joint Development Program or Independent Additional Studies and other activities under the Internal SAV Program Plans, POC Plans, Additional Research Plans, Joint Development Plan and Budget for the applicable Program and Independent Additional
Study Development Plans, the applicable Party represents and warrants (i) that it shall comply, with all applicable Laws relating to the collection and/or use of the Human Materials and (ii) that it has obtained or shall obtain, all
necessary approvals and appropriate informed consents, in writing, for the collection or use of such Human Materials. Each Party shall provide documentation of such approvals and consents upon the other Party’s request. The applicable Party
further represents and warrants that such Human Materials may be used as contemplated in this Agreement without any obligations to the individuals or entities (“Providers”) who contributed the Human Materials, including any
obligations of compensation to such Providers or any other Third Party for the intellectual property associated with, or commercial use of, the Human Materials for any purpose. 

5.3 Compliance with Corporate Policy. Each Party acknowledges that the other Party’s corporate policies require
that business must be conducted within the letter and spirit of the law. By signing this Agreement, each Party agrees to conduct the activities contemplated herein in a manner which is consistent with both law and good business ethics. Consistent
with the ‘Compliance Program Guidance for Pharmaceutical Manufacturers’ published by the Office of Inspector General, U.S. Department of Health and Human Services, each Party agrees to maintain a compliance program and policies and
adequate internal audit program with respect to its detailing and other Commercialization activities in the United States pursuant to this Agreement containing all the elements described in such guidance document, as well as completing any required
reporting to any Regulatory Authority. Each Party shall, promptly following the Effective Date, have in place and enforce, and at all times during the Term thereafter will have in place and will enforce, for its (and its Affiliates) employees, a
code of conduct and compliance program, including as provided under each Party’s respective corporate policies. 
 5.4
Business Partner Code of Conduct. Each Party endeavors to hold itself and its business partners to the highest performance, ethical and compliance standards, including basic human rights, encouraging fair and equal treatment for all persons,
the provision of safe and healthy working conditions, respect for the environment, the adoption of appropriate management systems and the conduct of business in an ethical manner. In performing its duties under this Agreement, each Party
acknowledges the value and importance of performance and ethical behavior in its performance under this Agreement. Without limiting any of Moderna’s other obligations hereunder, Merck expects that Moderna will abide by the letter and spirit of
Merck’s Supplier Performance Expectations and Business Partner Code of Conduct (the “Code”), a copy of which is available at http://www.merck.com/about/how-we-operate/code-of-conduct/values.html, in its performance of this Agreement. Moderna is also expected to follow the Pharmaceutical Supply Chain Initiative (PSCI)
principles, a copy of which is available at http://www.pharmaceuticalsupplychain.org/. In the event of a conflict or inconsistency between the Code and the express terms of this Agreement, this Agreement shall govern and prevail. 

  
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 5.5 Governments and International Public Organizations. Without limitation
of the foregoing, each Party warrants that none of its employees, agents, officers or other members of its management are officials, officers, agents, representatives of any government or international public organization. Each Party agrees that it
shall not make any payment, either directly or indirectly, of money or other assets, including the compensation derived from this Agreement (hereinafter collectively referred as a “Payment”), to government or political party
officials, officials of international public organizations, candidates for public office, or representatives of other businesses or persons acting on behalf of any of the foregoing (hereinafter collectively referred as “Officials”)
where such Payment would constitute a violation of any Law. In addition, regardless of legality, no Party shall make any Payment either directly or indirectly to Officials if such Payment is for the purpose of influencing decisions or actions with
respect to the subject matter of this Agreement or any other aspect of a Party’s businesses. 
 5.6 No Authority.
Each Party acknowledges that no employee of the other Party or its Affiliates shall have authority to give any direction, either written or oral, relating to the making of any commitment by such Party or its agents to any Third Party in violation of
terms of this or any other provisions of this Agreement. 
 5.7 Exclusions Lists. Each Party certifies to the other
Party that, as of the Effective Date and the Amended Effective Date, such Party has screened itself, and its officers and directors, against the Exclusions Lists and that it has informed the other Party whether such Party, or any of its officers or
directors has been in Violation. After the execution of this Agreement, each Party shall notify the other Party in writing immediately if any Violation occurs or comes to its attention, and shall, with respect to any person or entity in Violation,
promptly remove such person or entity from performing any Internal SAV Programs, POC Program, Joint Development Program, or and other activities hereunder, function or capacity related thereto. 

 

	6.	 MANUFACTURING AND SUPPLY 

6.1 During POC Program. 

(a) mRNA Cancer Vaccines and Collaboration Products. To the extent supply of mRNA Cancer Vaccines (including
Collaboration Products) or mRNA Constructs (formulated or unformulated) is required to perform the activities under a POC Plan for a given Program, Moderna shall be solely responsible (except as set forth in the applicable POC Plan, Exhibit
K, or as otherwise mutually agreed to by the Parties in writing) for Manufacturing such mRNA Cancer Vaccines (including Collaboration Products) or mRNA Constructs (formulated or unformulated) in accordance with such POC Plan for such Program and
this Agreement and the supply terms set forth in Exhibit K or pursuant to Section 10.13, as applicable. 

(b) Keytruda. To the extent supply of Keytruda is required to perform the Clinical Studies under a POC Plan for a given
Program, Merck shall be solely responsible for supplying such requirements of Keytruda in accordance with such POC Plan for such Program, this Agreement and the supply terms set forth in Exhibit K. 

  
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 (c) Manufacturing Capabilities. Pursuant to the POC Plan for a given
Program [***], Moderna will [***] to establish [***] for use as part of such POC Plan (and the Development Plans, if applicable) for such Program, which will include [***], in accordance with the Development Plans (or POC Plans, if applicable) and
this Agreement. [***] 
 (d) Inspections by Merck During POC Term. 

(i) During the SAV POC Term, to the extent Merck has not already conducted a quality audit and an EHS audit of the
Collaboration SAV Manufacturing Facility(ies) identified by Moderna pursuant to Section 6.1(c) in the preceding [***] period, Merck shall have a reasonable opportunity to conduct a quality audit and EHS audit of such Collaboration SAV
Manufacturing Facility(ies) prior to initiation of cGMP Manufacturing; provided, however, such [***] limitation shall not apply in the event that [***]. Quality audits under this Section may include an audit of [***]. 

(ii) At least [***] days prior to the anticipated expiration of the POC Term for a given Program, Merck, in each such
instance, shall have the right, during normal business hours [***] and with reasonable advance notice, to [***] with respect to the applicable Collaboration Products, solely for the purposes of assisting Merck in determining [***]; [***]. Moderna
will support such [***] by Merck by making appropriate resources available to provide the information, data, and records, and to answer questions from Merck. In connection with such [***]. With respect to any SAV Program, if Merck identifies any
audit observations in connection with any audits under this Section 6.1(d)(ii), the Parties will discuss in good faith suitable approaches for correcting such observations and will prepare a plan for correcting such observations for such SAV
Program; [***]. 
 (iii) With respect to an SAV Program and an audit by Merck of Collaboration SAV Manufacturing
Facility(ies) in accordance with Section 6.1(d)(i), if Merck identifies any audit observations, the Parties will discuss in good faith suitable approaches for correcting such observations and the Parties will prepare a plan for correcting such
observations for such SAV Program, [***]. 
 (iv) Notwithstanding Section 6.1(d)(i) and Section 6.1(d)(iii), the
Parties hereby acknowledge and agree that Merck has conducted, as of the Amended Effective Date, a quality audit and EHS audit with respect to the Collaboration SAV Manufacturing Facility(ies) designated to date for the Manufacture of Collaboration
SAV Products for the KRAS Program. As of the Amended Effective Date, as set forth on Schedule 6.1(d)(iv), Moderna and Merck have agreed to the timing and scope of the required corrective actions resulting from such quality and EHS audits.
[***] Merck acknowledges that the batches of mRNA-5671 Manufactured by Moderna in such Collaboration SAV Manufacturing Facility(ies) are suitable, as of the Amended Effective Date, for use in Clinical Studies for the KRAS Program, subject to [***].

 (e) Confidential CMC Documents. Notwithstanding anything in this Agreement to the contrary, during the POC
Term for a given Program, except with respect [***], Moderna may redact from documents provided or made available to Merck or its Affiliates, and otherwise decline to disclose or provide Merck access to, Moderna CMC Information and proprietary
manufacturing processes relating to Moderna CMC Information from such Program. 

  
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 6.2 Manufacture for Development During Merck Participation Term for a given
Program. 
 (a) mRNA Cancer Vaccines and Collaboration Products. To the extent supply of mRNA Cancer
Vaccines (including Collaboration Products) or mRNA Constructs (formulated or unformulated) is required to perform the activities under any Additional Research Plan for a given Program, Moderna shall be solely responsible (except as mutually agreed
by the Parties in writing or as set forth in the applicable Joint Development Plan and Budget) for Manufacturing such mRNA Cancer Vaccines (including Collaboration Products) or mRNA Constructs (formulated or unformulated) in accordance with such
Additional Research Plan for such Program and this Agreement. 
 (b) Merck’s Exercise of a Merck
Participation Election for SAV Programs. Subject to the remainder of this Section 6.2(b), to the extent supply of Collaboration SAV Products (including mRNA Constructs therefor) is anticipated to be required to perform the activities under
any Joint Development Plan and Budget, concurrent with Merck’s review of Moderna’s Manufacturing operations and the Parties’ preparation of a plan for correcting observations for such SAV Program as set forth in
Section 6.1(d)(ii), the Parties shall discuss in good faith and mutually agree on [***]. After receipt of [***], the Parties shall discuss in good faith [***]. After such joint discussion and evaluation, if the Parties are not able to agree
[***], then [***] shall have the right to make the final determination [***]. For the avoidance of doubt, the discussions and determination as set forth in this Section 6.2(b) for an SAV Program may take place during the POC Term for such SAV
Program as well as during the Merck Participation Term for such SAV Program. If the Parties mutually agree, or if [***], that [***], then [***] shall have a reasonable amount of time following such determination to [***]. 

(c) Merck’s Exercise of a Merck Participation Election for the PCV Program.  

(i) With respect to the PCV Program, if Merck identifies any audit observations in connection with any audits under
Section 6.1(d)(ii), the Parties will discuss in good faith suitable approaches for correcting such observations and, following the exercise of the Merck Participation Election for the PCV Program [***], will prepare a plan and a budget for
correcting such observations for the PCV Program, any resulting corrective action plan and budget must [***], and Moderna shall have a reasonable amount of time following such consultation with, and approval by, Merck to make appropriate
corrections. Moderna shall bear all of its own costs and expenses in connection with taking any such corrective actions in accordance with such plan and budget up to [***]. In the event that Moderna incurs costs and expenses in excess of [***] in
connection with taking such corrective actions in accordance with such plan and budget, such excess costs shall be treated as Shared Collaboration Costs with respect to the PCV Program under Exhibit D. 

(ii) [***] Merck, [***], shall purchase from Moderna up to such capacity ([***]), Collaboration PCV Product for use in
Development in connection with the performance of Collaboration Activities during the Merck Participation Term for the PCV Program until [***]. Following [***], upon [***] prior written notice to Moderna, [***]. 

  
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 (d) PCV Clinical Supply Agreement and Clinical Quality Agreements. At
least [***] days prior to the anticipated expiration of the POC Term for the PCV Program, the Parties shall initiate good faith discussions with respect to, and within [***] days after Merck exercises the Merck Participation Election for the PCV
Program enter into, a supply agreement and a Clinical Quality Agreement with respect to the Manufacture of Collaboration PCV Products for Development purposes during the Merck Participation Term for the PCV Program (if and to the extent Merck
exercises the Merck Participation Election), which supply agreement (the “PCV Clinical Supply Agreement”) and Clinical Quality Agreement will include mutually agreed terms and conditions in accordance with Exhibit M, and
shall otherwise include terms and conditions consistent with supply and quality agreements that are customary for agreements of this type which Merck utilizes with other non-affiliated Third Party
manufacturers. 
 (e) SAV Clinical Supply Agreement and Clinical Quality Agreements. At least [***] days prior to the
anticipated expiration of the SAV POC Term for the first SAV Program for which [***], the Parties shall initiate good faith discussions with respect to, and within [***] days after Merck exercises the Merck Participation Election for such SAV
Program, enter into a supply agreement and a Clinical Quality Agreement with respect to the Manufacture of Collaboration SAV Products for Development purposes during the Merck Participation Term for such SAV Program (if and to the extent
Merck exercises the Merck Participation Election for a given SAV Program), which supply agreement (the “SAV Clinical Supply Agreement”) and Clinical Quality Agreement will include mutually agreed terms and conditions in accordance
with Exhibit M, and shall otherwise include terms and conditions consistent with supply and quality agreements that are customary for agreements of this type [***]. In the event that [***], the Parties may mutually agree to amend the
existing SAV Clinical Supply Agreement to include Collaboration SAV Products from such subsequent SAV Program or enter into a new SAV Clinical Supply Agreement for such Collaboration SAV Products. 

(f) [***]; Supply Failure; Selection of Alternative Supplier. 

(i) If ([***], then Merck would have the right to cause Moderna to effect, and Moderna shall effect a technology transfer in
accordance with Exhibit H and the applicable Clinical Supply Agreement to Merck (or its Affiliate) or to a Manufacturing Subcontractor in order to permit Merck (or its Affiliate) or such Manufacturing Subcontractor to Manufacture the
applicable Collaboration Product to meet Merck’s requirements for Development activities under the applicable Program under this Agreement. All costs and expenses incurred by or on behalf of the Parties (or their Affiliates) in connection with
effecting such technology transfer in accordance with Exhibit H will be Shared Collaboration Costs. Without limiting the foregoing, Moderna shall keep Merck reasonably apprised [***]. Should a technology transfer as expressly set forth in
this Section 6.2(f)(i) be required or determined pursuant to Section 6.2(f)(ii), then [***]. During any technology transfer for a Collaboration PCV Product [***]. Following a successful technology transfer to Merck (or its Affiliate) or to
a Manufacturing Subcontractor in accordance with Exhibit H, Merck shall assume responsibility for the supply of Collaboration PCV Product for Development and Commercialization activities under the PCV Program, unless
otherwise agreed to by the Parties in writing. During any technology transfer for a Collaboration SAV Product[***]. 

  
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 (ii) Notwithstanding the terms of the SAV Clinical Supply Agreement, immediately
upon [***], the Parties, through the JMC, will review and discuss [***]. If the Parties reasonably determine (based on the considerations above) that the best available course of action [***] is for Moderna to [***], Moderna will, with Merck’s
input, [***]. If the Parties determine that it is in the best interests of the applicable Program for [***], then Moderna [***], and in such case the Parties will prepare an appropriate plan for review by the JMC and approval by the Parties,
including [***]. If the Parties determine that the best available remedy for ensuring that the foregoing requirements are met is some other approach, the Parties will prepare an appropriate plan to reflect such approach for review by the JMC and
approval by the Parties, including [***]. Notwithstanding the preceding provisions of this Section 6.2(f)(ii), if the Parties cannot agree on the best available course of [***], the matter will be resolved in accordance with [***]. During the
pendency of any such dispute resolution procedure, [***]. 
 (iii) If following a Supply Failure, there is a dispute as to
the best approach for ensuring [***], then the costs and expenses incurred by or on behalf of a Party or its Affiliates in connection with [***], shall be considered [***]. 

(g) Management of Development Manufacturing Capacity. 

(i) With respect to the Collaboration Products (except for any Collaboration SAV Product for which Moderna is not responsible
to supply [***]), Moderna, in consultation with Merck, shall prepare and maintain a quarterly forecast (each, a “Manufacturing Capacity Forecast”) of the supply of such Collaboration Products, [***]. The Manufacturing Capacity
Forecast for each applicable Program is to be updated [***]. The Manufacturing Capacity Forecast for each applicable Program is to be reviewed [***] by the JMC and used by the JMC in coordination with the JDC to inform plans for [***]. 

(ii) Should the addition or amendment of a Clinical Study to the Manufacturing Capacity Forecast for a given Program result in
the need to obtain additional Manufacturing capabilities (including [***], as determined by the JMC [***], the JMC shall jointly evaluate options to increase Manufacturing capabilities [***] with the goal of [***]. All [***] are subject to review by
the JMC [***], with respect to Collaboration PCV Products, and [***], with respect to Collaboration SAV Products (provided that [***]); provided that no such [***] shall require a Party to establish [***] without such Party’s prior written
consent. Any disputed matter with respect to Collaboration SAV Products pursuant to this Section 6.2(g)(ii) will be resolved in accordance with [***]. 

(h) To the extent there is a technology transfer pursuant to Section 6.2(f) as a result of [***], any costs and expenses
associated with establishing [***] that are incurred by or on behalf of [***], including [***], shall be considered [***]. 

(i) To the extent supply of Keytruda is required to perform the activities under a Development Plan, Merck shall be responsible
for supplying such requirements of Keytruda in accordance with such Development Plan and the supply terms set forth on Exhibit K. 

(j) To the extent supply of a Merck Agent is required to perform the activities under a Development Plan, Merck shall be
responsible for supplying such requirements of such Merck Agent in accordance with such Development Plan and the supply terms set forth on Exhibit K. To the extent supply of a Moderna Agent is required to perform the
activities under a Development Plan, Moderna shall be responsible for supplying such requirements of such Moderna Agent in accordance with such Development Plan and the supply terms set forth on Exhibit K. 

  
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 (k) To the extent supply of a Third Party Agent is required to perform the
activities under a Development Plan, the Party who has contracted with such Third Party for such Third Party Agent shall be responsible for supplying such requirements of such Third Party Agent in accordance with such Development Plan. 

6.3 Manufacture for Commercialization During Merck Participation Term for a given Program. 

(a) Manufacturing for Commercialization during Merck Participation Term for a given Program. With respect to a given
Program, considering the forecasted commercial volume requirements for the applicable Collaboration Product, the Parties shall jointly evaluate options to [***]. Notwithstanding the foregoing, with respect to any Collaboration SAV Product, [***].
The [***] with respect to the PCV Program is subject to review by the JMC and approval by [***] is subject to review by the JMC and approval by Parties, [***]; provided that if the Parties do not approve the [***] pursuant to this
Section 6.3(a), such dispute will be resolved in accordance with [***] neither Party’s plan [***]shall include a proposal requiring the other Party to [***]. The initial discussions regarding commercial supply of Collaboration SAV Products
may take place at the same time discussions are taking place pursuant to Section 6.2, and if commercial supply may be sourced at the same time [***], then the selection criteria under Section 6.2(b) shall also include [***]. If there is a
dispute regarding the Commercial Capacity Buildup Plan for a Joint SAV Program and the Parties resolve the dispute through [***], then the determination [***] and the Party responsible for [***] shall be responsible for payment of the costs and
expenses incurred in [***]; provided that such Party shall be entitled to [***]. 
 (b) Commercial Supply Agreements and
Commercial Quality Agreements. If Moderna [***], the Parties shall enter into a supply agreement and quality agreement with respect to Manufacture of the applicable Collaboration Product for commercial purposes, which supply agreement (the
“Commercial Supply Agreement”) and quality agreement (the “Commercial Quality Agreement”) shall contain terms and conditions consistent with supply and quality agreements that are customary for agreements of this
type that Merck utilizes with other non-affiliated Third Party manufacturers, including, [***]. 

6.4 Allocation of Capacity. Allocation of capacity for Collaboration Products among Exhibit K, the PCV Clinical
Supply Agreement, SAV Clinical Supply Agreement and the Commercial Supply Agreement will be prioritized, in descending order of priority, as follows: [***]. 

  
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	7.	 REGULATORY RESPONSIBILITIES DURING THE MERCK PARTICIPATION TERM FOR A GIVEN PROGRAM

 7.1 Merck Participation Term Lead Regulatory Party. 

(a) During the Merck Participation Term for a given Program, subject to Section 7.1(b), unless otherwise agreed to by the
Parties in writing, [***] shall be the Lead Regulatory Party and primarily responsible for regulatory matters with respect to the applicable Joint Development Program and the Collaboration Products for such Program. Subject to JDC oversight on the
overall regulatory strategy for the Collaboration Products for such Program, [***] shall have primary responsibility with respect to submitting Regulatory Filings (other than DMFs) for such Program. [***] shall be primarily responsible for all
communications with, and submissions to, Regulatory Authorities in connection therewith, provided that [***] shall have a reasonable opportunity to review and comment on the subject matter of all material Regulatory Filings (other than DMFs)
(including all material correspondence). At the reasonable request of [***], [***] shall prepare, or otherwise provide assistance in the preparation of, certain portions of Regulatory Filings ([***]) for such Program. In the event additional [***]
not currently contained within regulatory documents [***], the Parties shall mutually agree on the [***]. Subject to Section 7.1(b), [***] shall also be responsible for all routine maintenance of all INDs or CTAs for Collaboration Products for
such Program. [***] shall, subject to applicable Law, [***] shall provide such information and assistance as [***] may reasonably request in connection with the completion of and submission of and maintenance of Regulatory Filings for such Program,
including applications for Regulatory Approvals, and responses to agency inquiries (which information [***] shall provide in a timely manner to respond to the agency), for such Collaboration Products for such Program, and the maintenance thereof. In
the event [***] receives a request from a Regulatory Authority with respect to such Program for which disclosure of [***] will notify [***] promptly after receiving such request and the Parties shall discuss a course of action within a time frame
consistent with the time period requested by such Regulatory Authority, provided that in the event that the Parties are unable to agree on such course of action within such time frame, then such matter shall be referred to [***]. 

(b) During the Merck Participation Term for a given Program, notwithstanding Section 7.1(a), the Party sponsoring or
conducting an Independent Additional Study under an Independent Additional Study Development Plan for such Program (the “IAS Party”) shall be responsible for regulatory matters with respect to such Independent Additional Study for
such Program and the Collaboration Products thereunder, including filing and maintaining the IND or CTA for the conduct of such Independent Additional Study and communications with, and submissions to, Regulatory Authorities in connection with such
Independent Additional Study; provided, however, that if a Regulatory Authority requires that an Independent Additional Study be conducted under an IND or CTA held by the other Party (the “Non-IAS
Party”), then the Parties shall discuss in good faith an alternative approach if reasonably available. The non-IAS Party shall provide other information and assistance as the IAS Party may reasonably
request in connection with the completion of and submission of INDs or CTAs for Independent Additional Studies for such Program; provided, however, Moderna shall have no right to directly access the CMC data for [***]. In addition to the foregoing,
if [***]; provided that, if the applicable Regulatory Authority requires [***]. Without limiting the foregoing, the Parties agree to grant each other such Rights of Reference as are necessary, and to otherwise cooperate in good faith, to enable the
conduct of Independent Additional Studies in accordance with the terms of this Agreement, including to with respect to submission of Regulatory Filings, applications for Regulatory Approvals and the maintenance thereof. 

  
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 7.2 Ownership of Regulatory Filings. 

(a) Subject to Section 7.1(b) and Section 7.2(b), during the Merck Participation Term for a given Program, all
applications for Regulatory Approval, the Regulatory Approvals, and other Regulatory Filings (other than DMFs) (including all INDs and CTAs) relating to the applicable Collaboration Products will be the property of [***] and held in the name of
[***] or its designees. [***] shall provide the JDC with regular updates regarding the status of Regulatory Filings and correspondences for Collaboration Products, and such Regulatory Filings and correspondences shall be reviewed by the JDC or a
working group established by such committee. 
 (b) With respect to the Collaboration Products, if not previously prepared
and filed, Moderna will, at Merck’s request, prepare, file and maintain with all applicable Regulatory Authorities a DMF for the Collaboration Products and, subject to the remainder of this Section 7.2(b), Moderna shall also provide such
other information and assistance as Merck may reasonably request in connection with the completion of and submission of applications for Regulatory Approvals for Collaboration Products and the maintenance thereof. Merck and its Affiliates and
Sublicensees may refer to such DMF in any filing made in connection with obtaining or maintaining a Regulatory Approval for a Collaboration Product and [***] hereby grants such a Right of Reference. [***] will be responsible for assuring that during
the Term, such [***] will be in the form appropriate for filing with all applicable Regulatory Authorities, including those in [***], and [***] shall be maintained in full force and effect by [***] during the Term and will not be amended without the
consent of [***], other than with respect to amendments that [***] will, on written request by [***], provide to the requesting party and to any specified Regulatory Authority [***]. If [***] has not filed [***], then any and all [***] required to
be included in any Regulatory Filing [***] shall be provided by [***] to the appropriate individuals [***]. To the extent that [***], then [***] will first notify and discuss with the appropriate representatives at [***]; provided that such [***]
employees [***]. 
 (c) With respect to any Independent Additional Study, upon the IAS Party’s completion of an
Independent Additional Study for a given Program, the IAS Party will provide the data and related information and documents with respect thereto to the non-IAS Party, and the Parties will meet in person to
review and discuss the results and data of such study, the safety and efficacy profile of the proposed Collaboration Product or label expansion with respect to such Collaboration Product that could be requested via a filing for a Regulatory
Approval. [***] shall be responsible for filing, and, subject to [***] shall be obligated to file the application for Regulatory Approval for a given Collaboration Product following receipt of clinical data from the conduct of an Independent
Additional Study upon the request of the IAS Party for such Independent Additional Study; provided further that if not already assigned [***]. 

7.3 Adverse Event Reporting. During the Merck Participation Term for a given Program, prior to [***] shall be
responsible for individual and aggregate safety reporting for any Clinical Studies involving the applicable Collaboration Product for such Program (as applicable), [***] shall provide [***] an electronic copy of the [***]. Upon receipt of completion
of [***] shall assume responsibility for the individual and aggregate safety reporting (as applicable) [***]. Until [***], each Party agrees to notify the other Party of any information of which such Party becomes aware concerning any Adverse Events
with respect to such Collaboration Product for such Program. Such notice shall be provided in English in the form of a processed CIOMS I within [***] days of such Party receiving such information where such potential Adverse Events is a SAE and
associated with the clinical uses, Clinical Studies, investigations, tests or marketing of such Collaboration Product for such Program. Adverse Event reports of unexpected and fatal 

  
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or life-threatening events which are possibly, probably, definitely related or of unknown relationship to the use of a given Collaboration Product for such Program must be forwarded to the other
Party within [***] after receipt of such information. It is understood and agreed that these Adverse Events reporting requirement provisions are based on the respective policies and procedures of the Parties and applicable regulatory reporting
requirements. In the event of changes to applicable regulatory requirements for Adverse Events reporting, the Parties agree to comply with any such required revised notification requirements. At this same time, Moderna and Merck shall enter into
discussions regarding one or more pharmacovigilance agreements (or updates to the current pharmacovigilance agreement) for the Collaboration Product for such Program, as applicable (the “Pharmacovigilance Agreement”). In all cases,
[***]. For the avoidance of doubt, [***]. 
 7.4 Right of Reference During Merck Participation Term for a given
Program. During the Merck Participation Term for a given Program, each Party shall provide to the other, as necessary, a cross-reference letter or similar communication to the applicable Regulatory Authority to effectuate the Right of Reference
such other Party’s Other Component(s) that are included in a Development Plan. Notwithstanding anything to the contrary in this Agreement, neither Party shall have any right to access the other Party’s CMC data with respect to a Moderna
Agent, Merck Agent or Keytruda, as applicable. Each Party shall authorize FDA and other applicable Regulatory Authorities to cross-reference the applicable INDs and CTAs for any Collaboration Product, Moderna Agent, Merck Agent or Keytruda, as
applicable, used in the conduct of a Clinical Study for such Program under a Development Plan to provide data access to the other Party sufficient to support conduct of any Clinical Study sponsored by such other Party involving such
Collaboration Product for such Program, Moderna Agent, Merck Agent or Keytruda, as applicable. If a Party’s IND or CTA for such Program is not available in a given country, subject to [***], such Party will file its CMC data for such Program
with the applicable Regulatory Authority for such country, referencing the other Party’s IND or CTA for such Program as appropriate (however, [***]. The Party conducting a Clinical Study under a Right of Reference shall (a) track and
collect financial disclosure information from all “clinical investigators” involved in such Clinical Study for such Program and (b) prepare and submit the certification or disclosure of the same in accordance with all applicable Law,
including Part 54 of Title 21 of the United States Code of Federal Regulations (Financial Disclosure by Clinical Investigators) and related FDA Guidance Documents. Prior to the initiation of clinical activities under any Clinical Study for such
Program sponsored by (a) Moderna involving a Collaboration Product for such Program, Keytruda or a Merck Agent or (b) Merck involving a Moderna Agent, the Parties shall determine, in writing, whether the Party conducting such Clinical
Study for such Program shall track and collect separate certification or disclosure forms for each of Merck and Moderna or one (1) “combined” certification or disclosure form for both Merck and Moderna. For purposes of this
Section 7.4, the term “clinical investigators” shall have the meaning set forth in Part 54.2(d) of Title 21 of the United States Code of Federal Regulations. 

7.5 Regulatory Costs. During the Merck Participation Term for a given Program, the reasonable and documented costs and
expenses of the Parties in performing its respective regulatory obligations pursuant to this Section 7 prior to receipt of Regulatory Approval for a given Collaboration Product for such Program shall be considered Development Costs. 

  
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	8.	 COMMERCIALIZATION RESPONSIBILITIES 

8.1 Overview. On a Collaboration Product-by-Collaboration Product basis, subject to the oversight of the JSC and JCC and
the remainder of this Section 8, Merck will plan Commercialization Activities with respect to such Collaboration Product in the Territory, including discussing such plans with Moderna and the Co-Promotion of such Collaboration Products by
Moderna in the U.S. Merck will be solely responsible for all Commercialization Activities relating to such Collaboration Product in the Territory, including the booking of all sales of Collaboration Products, subject to Moderna’s right to
perform certain Co-Promotion activities (with Merck) in the United States as specified in Sections 8.5 and 8.6 and any Co-Promotion Agreement. 

8.2 Commercialization Efforts. 

(a) United States. On a Collaboration Product-by-Collaboration Product basis, Merck (itself or through one or more
Affiliates) will use Commercially Reasonable Efforts to Commercialize such Collaboration Product in the U.S., and to carry out the tasks specified under the Global Commercialization Plan for such Collaboration Product in the U.S. in a timely and
effective manner and in compliance in all material respects with applicable Law. 
 (b) Ex-U.S. On a Collaboration
Product-by-Collaboration Product basis, Merck (itself or through one or more Affiliates) will use Commercially Reasonable Efforts to Commercialize such Collaboration Product ex-U.S., and to carry out the tasks specified under the Global
Commercialization Plan for Merck for such Collaboration Product ex-U.S. in a timely and effective manner and in compliance in all material respects with applicable Law. 

8.3 Global Commercialization Strategy. Before the Commencement of the first Registrational Study for any Collaboration
Product following the exercise of the Merck Participation Election for the applicable Program, Merck shall provide, and within [***] days after such provision the JCC will review and update for approval by the JSC, a written summary of the global
Commercialization strategy for all Collaboration Products included in the Joint Development Plan and Budget for the applicable Program in the Territory. Such strategy should include [***]. For clarity, any and all such communications and strategy
involving the Commercialization of a Collaboration Product will be limited to those permitted under applicable Law, including antitrust Laws. 

8.4 Global Commercialization Plan(s). 

(a) Initial Global Commercialization Plan(s). For each Collaboration Product, an initial high-level Global
Commercialization Plan shall be prepared by Merck and submitted to the JCC for review and JSC approval no later than [***] prior to the anticipated date of first filing for Regulatory Approval for such Collaboration Product. The JCC will set the
required form and contents of such Global Commercialization Plan, which will include activities relating to [***]; provided that, for clarity, the JCC may determine that not all of the foregoing elements are appropriate for inclusion in the initial
Global Commercialization Plan or updates thereto prior to Collaboration Product launch. 

  
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 (b) Global Commercialization Budget(s). At such times as the JCC
will deem appropriate, but in no event later than [***] prior to the anticipated date of first filing for Regulatory Approval for a Collaboration Product, and concurrently with the preparation of the initial Global Commercialization Plan, on a
Collaboration Product-by-Collaboration Product basis, Merck will prepare an initial budget for the Global Commercialization Plan for such Collaboration Product, that outlines the financial resources and expenses to be incurred by or on behalf of the
Parties (or their Affiliates) in execution of the Global Commercialization Plan, with input from Moderna on costs associated with activities assigned to Moderna in the associated Global Commercialization Plan (each a “Global
Commercialization Budget”). The JCC will review and comment on and the JSC will approve such Global Commercialization Budget; provided that the Global Commercialization Budget may not be increased by more than [***] of the anticipated
Allowable Commercialization Costs in such Global Commercialization Budget within a Calendar Year without submitting an amended Global Commercialization Budget for review and comment by the JCC and approval by the JSC; provided that, Merck shall have
the right to incur Commercialization costs in excess of [***] of the anticipated Allowable Commercialization Costs in such Global Commercialization Budget within a Calendar Year to the extent that such Commercialization costs that are not previously
approved by the JSC shall be solely borne by Merck for the purposes of calculating each Party’s share of the Cash Profits or Losses for such Calendar Year. Thereafter, Merck, with input from Moderna, will update the Global Commercialization
Budget at least [***] per Calendar Year (and in any event at any time the Global Commercialization Plan is updated or amended with respect to any Commercialization Activities), and the JCC will review and comment on and the JSC shall approve any
such update or any other amendment to the Global Commercialization Budget. The JCC will set the required form and contents of the Global Commercialization Budget, but at a minimum the contents shall include [***].  

(c) Updated Global Commercialization Plan(s) and Global Commercialization Budget(s). Not later than [***] of each
Calendar Year, or more often as the Parties mutually deem appropriate, Merck shall submit to the JCC for review and comment updated Global Commercialization Plans and Global Commercialization Budgets for the following Calendar Year, which the JCC
shall review and comment on, and the JSC shall approve, no later than [***] of such Calendar Year and attach to the minutes of the meeting of the JSC at which any Global Commercialization Plan, Global Commercialization Budget or any amendment,
modification or update to either or both is approved by the JSC. 
 8.5 Co-Promotion of Collaboration Products in U.S.

 (a) Co-Promotion. Except as otherwise set forth in this Agreement, the Parties intend that the Parties will share
in the Co-Promotion of Collaboration Products in the U.S. on the terms and conditions set forth in this Section 8.5 and Section 8.6. 

(b) Co-Promotion Agreements. On a Collaboration Product-by-Collaboration Product basis, prior to the submission of the
first Global Commercialization Plan for such Collaboration Product to the JCC, the Parties will enter into a co-promotion agreement (the “Co-Promotion Agreement”) setting forth the terms and conditions of the Parties’
Co-Promotion of such Collaboration Product in the U.S. Each Co-Promotion Agreement will be consistent with this Section 8.5 and Section 8.6, and will contain additional reasonable and customary terms and

  
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conditions, including an equitable allocation of responsibilities for the Co-Promotion of such Collaboration Product and the promotional efforts in the U.S. The Parties may commence negotiating
the terms and conditions of the Co-Promotion Agreement at any time after the commencement of the Merck Participation Term for a given Program. 

8.6 Co-Promotion Terms. Each Co-Promotion Agreement entered into pursuant to Section 8.5 will reflect the
principles set forth in this Section 8.6, unless otherwise expressly agreed by the Parties. 
 (a) Team Building and
Training. Merck will direct the standards for job descriptions, qualifications, roles, responsibilities and training of Moderna’s sales representatives and key account managers and Moderna will prepare and implement, consistent in all
material respects with the Global Commercialization Plan, a training program and training materials for such sales representatives, to which Merck may contribute, at its election. In addition, Merck will specify the conduct and content of details
(including detail scripts) for a Collaboration Product. Moderna will cause each of its sales representatives and key account managers assigned to a Collaboration Product to attend and complete the training program developed by Merck for such
Collaboration Product in the U.S. to assure a consistent, focused promotional strategy and message as and to the extent consistent with applicable Law. 

(b) Responsibilities. Subject to Section 8.6(c) below, each Party will be solely responsible for recruiting, hiring
and maintaining its sales force of sales representatives and key account managers for promotion of a Collaboration Product in accordance with its standard procedures and the requirements of this Agreement. Each Party will be responsible for the
activities of its sales representatives and key account managers, including compliance by its sales representatives and key account managers with training and detailing requirements. In particular, each Party will provide its sales representatives
and key account managers assigned to a Collaboration Product with the level of oversight, management, direction and sales support with respect to the promotion of such Collaboration Product necessary to effectively and efficiently promote such
Collaboration Product in accordance with the terms of this Agreement and applicable Law. 
 (c) Sales Force Matters.

 (i) Number of Representatives. Moderna will have the right, but not the obligation, to provide no less than [***]
but no more than [***] of the total sales representatives and of the total key account managers used by both Parties for promotion of a Collaboration Product in the U.S. The Global Commercialization Plan for a Collaboration Product that is intended
to be Co-Promoted in the U.S. will set forth the precise number of Moderna sales representatives and key account managers consistent with the foregoing and Moderna shall [***]s. Each Party agrees that any of its sales representatives or key account
managers involved in the promotion of a Collaboration Product will not have any legal or regulatory disqualifications, bars or sanctions. 

(ii) Establishment; Launch Readiness. No later than [***] prior to the estimated date of the launch of the first
Collaboration Product in the U.S., Moderna will present its sales representative and key account manager capabilities to Merck. If Merck identifies [***], then Merck shall have the right to [***]. 

  
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 (iii) Hiring. Moderna will be solely responsible for recruiting, hiring
and maintaining its sales representatives and key account managers in accordance with [***], if any, and shall have sole control over such sales representatives and key account managers. Notwithstanding the foregoing, however, upon Moderna’s
reasonable request, Merck will assist Moderna in the establishment of the sales representatives and key account managers by providing assistance with the profiling of personnel during hiring. 

(iv) Use of Contract Sales Organizations. [***]. 

(v) Compensation Programs for Sales Representatives. Each Party shall be solely responsible for any compensation that
is payable to its sales representatives and key account managers consistent with the applicable Global Commercialization Plan. Each Party represents and warrants to the other Party that its compensation programs for its sales representatives and key
account managers do not, and will not, provide financial incentives that, to its knowledge, facilitate the promotion, sales, and marketing of the Collaboration Product in violation of applicable Laws. 

(d) Promotional Materials. In the United States, to the extent Moderna is Co-Promoting, each Party’s sales
representatives and key account managers assigned to a Collaboration Product will utilize only Promotional Materials that have been approved by the JCC. All detailing activities conducted by each Party’s sales representatives will be consistent
in all material respects with the Promotional Materials so approved. Each Party will train and instruct their respective sales representatives to make only those statements and claims regarding such Collaboration Product, including as to efficacy
and safety, which are consistent with such Collaboration Product labeling and accompanying inserts and the approved Promotional Materials. 

(e) JCC Reports. Each of Merck and Moderna will provide the JCC with a report, as soon as practicable but in no event
later than [***] days following the end of each Calendar Quarter during the Term following the Regulatory Approval of a Collaboration Product to be Commercialized in the U.S., setting forth the number of details made by its sales representatives of
such Collaboration Product in the U.S. during such Calendar Quarter. Costs and expenses for sales representatives and key account managers will be charged to the Profit & Loss Share as in Exhibit D. 

(f) Records. Each Party will maintain records and otherwise establish procedures to ensure compliance with all
applicable Laws and professional requirements that apply to the promotion and marketing of the Collaboration Products. 
 8.7
Branding. To the extent permitted by applicable Law and applicable Regulatory Authorities, all Collaboration Products sold in or distributed for the Territory will have the corporate brands of each Party displayed on an equally prominent
basis. At such time as the JCC will deem appropriate, the Parties will enter into appropriate trademark licensing agreements to achieve the foregoing. 

8.8 Promotional Materials. Merck will be responsible for the creation, preparation, production, reproduction and filing
with the applicable Regulatory Authorities, of relevant Promotional Materials relating to each Collaboration Product for use in the Territory. All such Promotional Materials will be compliant with applicable Law and, if applicable, consistent in all
material respects with the Global Commercialization Plan for such Collaboration Product and, if applicable, consistent in all material respects with the branding strategy for such Collaboration Product. 

  
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 8.9 Sales and Distribution. 

(a) Collaboration Products. Merck will be solely responsible for booking of sales, handling all returns, recalls, order
processing, invoicing and collection, inventory and receivables, and, subject to the good faith consideration by Merck of input from Moderna, Distribution Matters relating to each Collaboration Product in the Territory. Moderna will not accept
orders for Collaboration Products or make sales for its own account or for Merck’s account, and if Moderna receives any order for Collaboration Products in the Territory, it will refer such orders to Merck for acceptance or rejection. Merck
will be solely responsible for negotiating and contracting with managed care entities, hospitals, integrated systems, pharmacies, long term care organizations, group purchasing organizations, pharmacy benefit managers, and governments, consistent in
all material respects with the Global Commercialization Plan. 
 (b) Keytruda and Merck Agents. Merck will be solely
responsible for all Commercialization activities for Keytruda and for all Merck Agents in the Territory, in each case including handling all returns, recalls, order processing, invoicing and collection, booking of sales, inventory and receivables,
government pricing programs and medical affairs, including negotiating and contracting with managed care entities, hospitals, integrated systems, pharmacies, long term care organizations, group purchasing organizations, pharmacy benefit managers,
and governments. Moderna will not accept orders for Keytruda or for Merck Agents, or make sales for its own account or for Merck’s account, and if Moderna receives any order for Keytruda or a Merck Agent (as applicable) in the Territory, it
will refer such orders to Merck for acceptance or rejection. For clarity, Moderna shall have no rights to any revenue from any Merck Agent or Keytruda. 

(c) Moderna Agents. Moderna will be solely responsible for all Commercialization activities for all Moderna Agents in
the Territory, in each case including handling all returns, recalls, order processing, invoicing and collection, booking of sales, inventory and receivables, government pricing programs and medical affairs, including negotiating and contracting with
managed care entities, hospitals, integrated systems, pharmacies, long term care organizations, group purchasing organizations, pharmacy benefit managers, and governments. Merck will not accept orders for Moderna Agents or make sales for its own
account or for Moderna’s account, and if Merck receives any order for Moderna Agents in the Territory, it will refer such orders to Moderna for acceptance or rejection. For clarity, Merck shall have no rights to any revenue from any Moderna
Agent. 

  
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 (d) Third Party Agents. With respect to any Third Party Agent to be used
in combination with any Collaboration Product, the Parties will discuss in good faith and agree upon the allocation of responsibilities for Commercialization activities for such Third Party Agent in combination with a Collaboration Product in the
Territory, if and to the extent either Party has any rights in or to such Third Party Agent. 
 8.10 Commercialization
Reports. Each Party will keep the JCC fully informed regarding the progress and results of Commercialization activities for Collaboration Products in the U.S., including [***]. Merck will provide the JCC on a [***] basis a rolling annual
forecast of projected unit sales, revenue and market share for Collaboration Products ex-U.S. The Parties will work together to provide such forecast for Collaboration Products in the U.S. 

8.11 [***]  

(a) [***] 

(b) [***] 

(c) [***] 

8.12 [***] 
  

	9.	 PAYMENTS 

9.1 Program Funding. The Parties agree and acknowledge that pursuant to the terms of the Original Agreement, Merck has
previously paid Moderna a one-time payment of Two Hundred Million Dollars (U.S. $200,000,000) (the “Upfront Payment”), which payment will be non-refundable, non-creditable, not subject to set-off, and not be reduced by any
withholding or similar taxes. Subject to Sections 3.5(d) and 3.7(b) and Exhibit D, Moderna shall utilize the Upfront Payment for the performance of Collaboration Activities for the PCV Program under this Agreement. 

9.2 Non-Exercise of Merck Participation Election. If Merck does not exercise the Merck Participation Election for a
given Program, (a) [***], no further payments shall be due under this Agreement from Merck to Moderna with respect to such Program or the Collaboration Products thereunder (other than with respect to any payment obligations that have accrued
prior to the Merck Participation Election Period expiry for such Program, Merck’s indemnification obligations under Section 13.6(a) or for supply of the applicable Collaboration Products in accordance with Section 3.7) and
(b) Moderna shall pay to Merck for a given Calendar Quarter its share of (1) Moderna Net Profits allocated to sales of any Financial PCVs or (2) the Moderna Net Profits allocated to sales of any Financial SAVs up to an aggregate
amount equal to the Merck SAV Program Costs (at which point, such SAVs shall cease to be Financial SAVs) in accordance with Exhibit E. 

  
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 9.3 Exercise of Merck Participation Election. 

(a) Participation Election Payment.  

(i) If Merck exercises the Merck Participation Election for the PCV Program, then within [***] Business Days after the
exercise of the Merck Participation Election for the PCV Program, and receipt of an invoice from Moderna, Merck will pay to Moderna a one-time payment of Two Hundred Fifty Million Dollars (U.S. $250,000,000) (the “PCV Participation Election
Payment”), which payment will be non-refundable, non-creditable, not subject to set-off, and not be reduced by any withholding or similar taxes. 

(ii) If Merck exercises the Merck Participation Election for a given Joint SAV Program, then within [***] Business Days after
the Parties agree to the initial Joint Development Plan and Budget for such Joint SAV Program in accordance with Section 4.3(c)(i), Moderna will send an invoice to Merck, and within [***] Business Days after receipt of such invoice, Merck will
pay to Moderna a one-time payment of, as applicable, (i) with respect to the exercise of the Merck Participation Election for the KRAS Program, [***], or (ii) for a Joint SAV Program other than the KRAS Program, (A) if prior to the
Merck Participation Election for such Joint SAV Program, Merck has not previously exercised the Merck Participation Election for any Joint SAV Program, [***], (B) if prior to the Merck Participation Election for such Joint SAV Program, Merck
has exercised the Merck Participation Election for any Joint SAV Program, [***], or (C) thereafter for any other Joint SAV Program, [***] (each, an “SAV Participation Election Payment”, and together with the PCV Participation
Election Payment, each a “Participation Election Payment”), which payment will be non-refundable, non-creditable, not subject to set-off, and not be reduced by any withholding or similar taxes. 

(b) Profit & Loss Share. If Merck pays the Participation Election Payment for a given Program, then, subject
to [***] and Exhibit E with respect to a Joint SAV Program, the Parties will share in Cash Profits or Losses with respect to Collaboration Products from such Program as follows: Moderna will bear (and be entitled to) fifty percent (50%), and
Merck will bear (and be entitled to) fifty percent (50%) (the “Profit & Loss Share”). [***] Procedures for Calendar Quarter reporting of actual results and review and discussion of potential discrepancies, quarterly
reconciliation, reasonable forecasting, and other finance and accounting matters, are set forth on Exhibit D, and to the extent not set forth in Exhibit D, will be established by the JSC, subject to Section 2.7(b). 

9.4 Payments for In-Licenses. The Parties will make payments for In-Licenses in accordance with Exhibit D, Exhibit
E and Exhibit F. 
 9.5 Payment Terms. 

(a) Manner of Payment. All payments to be made by a Party hereunder will be made in U.S. dollars by wire transfer to
such bank account as the other Party may designate. 
 (b) Reports and Payments of Cash Profits or Losses. For as long
as payments are due under this Section 9, Merck or Moderna will furnish to the other Party, as applicable, a written report, after the end of each Calendar Quarter, showing the amount of Cash Profits or Losses and each Party’s allocation
of the Cash Profits or Losses in accordance with Exhibit D and Exhibit E, and any other payments accrued during such Calendar Quarter. 

  
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 (c) Records; Audits. Each Party will keep, and will cause each of their
other Selling Parties, as applicable, to keep adequate books and records of accounting for the purpose of calculating all amounts payable by either Party to the other Party hereunder and ensuring each Party’s compliance hereunder. For the [***]
following the end of the Calendar Year to which each will pertain, such books and records of accounting (including those of its Affiliates, as applicable) will be kept at each of their principal place of business. At the request of either Party, the
other Party will permit (and procure its Affiliates, to permit) an independent certified public accounting firm of internationally recognized standing selected by the auditing Party and reasonably acceptable to the other Party to have access during
normal business hours to such of the records as may be reasonably necessary to verify the accuracy of the payments due hereunder for any Calendar Year ending not more than [***] following the end of any Calendar Year. Such examinations may not be
conducted more than [***] in any Calendar Year or be repeated for any Calendar Year. The accounting firm shall disclose to the auditing Party only whether the reports are correct or incorrect and the amount of any discrepancy. No other Confidential
Information shall be provided. If such accounting firm correctly identifies a discrepancy made during such period, the appropriate Party shall pay the other Party the amount of the discrepancy within [***] days of the date of delivery of such
accounting firm’s written report so correctly concluding, or as otherwise agreed upon by the Parties. The fees charged by such accounting firm shall be paid by the auditing Party, provided that if the underpayment or overcharge exceeds [***],
the audited Party shall pay the fees. Upon the expiration of [***] following the end of any Calendar Year, absent willful misconduct or fraud by a Party (its Affiliates, as applicable) the calculation of amounts payable with respect to such Calendar
Year shall be binding and conclusive upon the Parties, and the Parties shall be released from any liability or accountability with respect to amounts payable for such Calendar Year. The auditing Party shall treat all financial information subject to
review under this Section 9.5(c) in accordance with the confidentiality and non-use provisions of this Agreement, and shall cause its accounting firm to enter into an acceptable confidentiality agreement with the audited Party obligating it to
retain all such Confidential Information in confidence pursuant to such confidentiality agreement. 
 (d) Taxes.
Subject to Section 9.1 and Section 9.3, a Party may deduct or withhold from any payments due to the other Party amounts for payment of any withholding Tax that is required by Law to be paid to any tax authority with respect to such
payments. To the extent that any such amounts are so deducted or withheld, such amounts will be treated for all purposes of this Agreement as having been paid to the other Party. The paying Party will give written notice of its intent to withhold
any amounts under this Section 9.5(d) at least [***] days in advance of any payment being made. The paying Party will give proper evidence as to the payment of any such Tax within a reasonable amount of time, but in any event within [***] days
of payment. The receiving Party will provide the paying Party all necessary documents and correspondence, and will also use commercially reasonable efforts to provide to the paying Party any other cooperation or assistance on a reasonable basis as
may be necessary to enable the paying Party to claim exemption from such deduction or withholding Taxes. The Parties will reasonably cooperate with each other in seeking relief or reduction in the deduction or withholding of any Tax under any double
Taxation or other similar treaty or agreement from time to time in force and in seeking to receive a refund of any withholding Tax or to claim a foreign Tax credit. 

  
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 (e) Currency Exchange. With respect to Net Sales invoiced in U.S. dollars, the
Net Sales and the amounts due hereunder will be expressed in U.S. dollars. In the case of sales outside the United States, the rate of exchange to be used in computing the monthly amount of currency equivalent in United States Dollars due a Party
shall be made at [***]. 
 (f) Blocked Payments. In the event that, by reason of applicable Law in any country, it becomes
impossible or illegal for the paying Party (or any other Selling Party) to transfer, or have transferred on its behalf, payments owed the other Party hereunder, the paying Party will promptly notify the other Party of the conditions preventing such
transfer and such payments will be deposited in local currency in the relevant country to the credit of the other Party in a recognized banking institution designated by the other Party or, if none is designated by the other Party within a period of
[***] days, in a recognized banking institution selected by the paying Party or another Selling Party, as the case may be, and identified in a written notice given to the other Party. 

(g) Interest Due. If any payment due to either Party under this Agreement is overdue (and is not subject to a good faith
dispute), then such paying Party will pay interest thereon (before and after any judgment) at an annual rate [***] of the lesser of [***] after payment of such sum became due until payment thereof in full together with such interest. 

9.6 Equity Investment. Moderna and Merck will enter into the Equity Agreement as of the Amended Effective Date. 

 

	10.	 LICENSES; EXCLUSIVITY 

10.1 Grants to Merck. 

(a) Licenses During Internal SAV Program Term and POC Term.  

(i) Subject to the terms of this Agreement, solely to the extent Merck conducts any Research activities under a given Internal
SAV Program Plan for a Merck Internal SAV Program, during the Internal SAV Program Term for such Merck Internal SAV Program, Moderna, on behalf of itself and its Affiliates, hereby grants to Merck a sublicensable (subject to Section 10.3(a)),
worldwide, co-exclusive license (with Moderna and its Affiliates), under the Moderna Technology to perform Research activities under such Internal SAV Program Plan. 

(ii) Subject to the terms of this Agreement, solely to the extent Merck has any Research, Development or Manufacturing
obligations under a given POC Plan, during the POC Term for such Program, Moderna, on behalf of itself and its Affiliates, hereby grants to Merck a sublicensable (subject to Section 10.3(a)), worldwide, co-exclusive license (with Moderna and
its Affiliates), under the Moderna Technology to perform Research or Development under such POC Plan, or to perform such Manufacturing activities set forth in such POC Plan, Supply Agreement, or Exhibit K, or as mutually agreed by the Parties
in writing; provided, for clarity, Merck will exercise its rights to Manufacture solely (A) as set forth in the applicable POC Plan, Supply Agreement, or Exhibit K, or as mutually agreed by the Parties in writing or (B) after the
occurrence of an event that obligates Moderna to effect a technology transfer to Merck for such POC Plan hereunder. 

  
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 (b) Licenses in the Event of a Merck Non-Participation. Subject to
the terms of this Agreement, in the event a Merck Non-Participation for the PCV Program occurs, then, Moderna, on behalf of itself and its Affiliates, hereby grants to Merck [***]. 

(c) Licenses Following the Merck Participation Election Date. Subject to the terms of this Agreement, including Sections
10.8, 10.10 and [***], during the Merck Participation Term for a given Program, Moderna, on behalf of itself and its Affiliates, hereby grants to Merck sublicensable (subject to Section 10.3(a)), worldwide licenses, under the Moderna
Technology, to: 
 (i) Research mRNA Cancer Vaccines for such Program, only under and in accordance with any applicable
Additional Research Plan for such Program; provided, however, that [***]; 
 (ii) Develop Collaboration Products from such
Program, under and in accordance with any applicable Joint Development Plan and Budget for such Program or Independent Additional Study Development Plan for such Program; 

(iii) Commercialize Collaboration Products from such Program in the Territory; and 

(iv) subject to Section 10.1(e), Manufacture Collaboration Products from such Program; provided, for clarity, Merck will
exercise its rights to Manufacture any Collaboration Product solely [***]; 
 Subject to Section 10.1(e), the licenses set forth in
clauses (i), (ii) and (iv) will be co-exclusive (with Moderna and its Affiliates), and the license set forth in clause (iii) will be exclusive (even as to Moderna and its Affiliates but subject to Sections 8.5 and 8.6). 

(d) Additional Licenses. Subject to the ter ms of this Agreement (including Section 3.1(d), 10.8, 10.10 and
[***] and without limiting Section 10.1(b)), Moderna, on behalf of itself and its Affiliates, hereby grants to Merck, [***]: 

(i) under [***] 

(ii) under [***] 

(iii) under [***]. 

(e) Retained Rights; Limitations. Notwithstanding the co-exclusive or exclusive licenses set forth in
Section 10.1(a) or Section 10.1(c), Moderna retains rights under the Moderna Technology to perform and to have its Affiliates, Sublicensees and Third Party subcontractors, and Third Party licensees (and Moderna will be responsible for
ensuring the performance and compliance by such Third Party licensee with the applicable terms of this Agreement as if such Third Party were “Moderna” hereunder), perform Moderna’s assigned obligations and responsibilities and
exercise its rights under this Agreement (including any Internal SAV Program Plan, POC Plan, any Additional Research Plan or any Development Plan), any Supply Agreement and any Co-Promotion Agreement, provided Moderna complies with Section 10.4
for any such Third Party subcontractors. 

  
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 10.2 Grants to Moderna. 

(a) Licenses During Internal SAV Program Term and POC Term.  

(i) Subject to the terms of this Agreement, solely to the extent Moderna conducts Manufacturing activities in accordance with
the supply terms set forth in Exhibit N for a given Merck Internal SAV Program, during the Internal SAV Program Term for such Merck Internal SAV Program, Merck, on behalf of itself and its Affiliates, hereby grants to Moderna a sublicensable
(subject to Section 10.3(a)), worldwide, co-exclusive license (with Merck and its Affiliates), under the Merck Technology to perform Manufacturing activities on SAVs in accordance with the terms set forth in Exhibit N for such Merck Internal
SAV Program. 
 (ii) Subject to the terms of this Agreement, solely with respect to Moderna’s Research, Development and
Manufacturing activities under a given POC Plan or, to the extent permitted pursuant to Section 3.3(d), during the POC Term for such Program, Merck, on behalf of itself and its Affiliates, hereby grants to Moderna a sublicensable (subject to
Section 10.3(b)), worldwide, co-exclusive license (with Merck and its Affiliates), under the Merck Technology, to perform Research, Development and Manufacturing activities under the applicable POC Plan or as otherwise provided by
Section 3.3(d). 
 (b) Licenses in the Event of a Merck Non-Participation. Subject to the terms of this
Agreement, in the event a Merck Non-Participation occurs for a given Program [***] then Merck, on behalf of itself and its Affiliates, hereby grants to Moderna [***]. 

(c) Licenses Following the Merck Participation Election Date. Subject to the terms of this Agreement, including Sections
10.7, 10.10 and [***], during the Merck Participation Term for a given Program, Merck, on behalf of itself and its Affiliates, hereby grants to Moderna a sublicensable (subject to Section 10.3(b)), worldwide licenses, under the Merck
Technology, to: 
 (i) Research mRNA Cancer Vaccines for such Program, solely under and in accordance with any applicable
Additional Research Plan for such Program; provided, however, that [***]; 
 (ii) Develop Collaboration Products from such
Program, under and in accordance with any applicable Joint Development Plan and Budget for such Program or Independent Additional Study Development Plan for such Program; and 

(iii) subject to Sections 6.2 and 6.3, Manufacture Collaboration Products from such Program in accordance with the applicable
Supply Agreements. 
 Subject to Section 10.2(e), the licenses set forth in clauses (i), (ii) and (iii) will be co-exclusive
(with Merck and its Affiliates). 

  
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 (d) Additional Licenses. Subject to the terms of this Agreement (including
Section 10.7), Merck, on behalf of itself and its Affiliates, hereby grants to Moderna [***]: 
 (i) under [***]; 

(ii) under [***]. 

(iii) under [***]. 

(e) Retained Rights; Limitations. Notwithstanding the co-exclusive licenses set forth in Section 10.2(a) or
Section 10.2(c), Merck retains rights under the Merck Technology to perform and to have its Affiliates, Sublicensees and Third Party subcontractors, and Third Party licensees (and Merck will be responsible for ensuring the performance and
compliance by such Third Party licensee with the applicable terms of this Agreement as if such Third Party were “Merck” hereunder), perform Merck’s assigned obligations and responsibilities and exercise its rights under this Agreement
(including any Internal SAV Program Plan, POC Plan, any Additional Research Plan or any Development Plan) or any Supply Agreement, provided Merck complies with Section 10.4 for any such Third Party subcontractors. 

10.3 Sublicensing. 

(a) Merck Sublicensing. Merck may grant sublicenses under any of the licenses granted to Merck by Moderna under
Section 10.1 or to the Rights of Reference granted under this Agreement, (1) to one or more Affiliates (with the right to sublicense through multiple tiers in accordance with this Agreement) without requiring Moderna’s prior written
consent, (2) to one or more Third Party subcontractors (in accordance with Section 10.4) of Merck (or its Affiliate) to perform the subcontracted activities, [***]; provided that[***], the grant of any such sublicense to an Affiliate or
Third Party shall not relieve Merck of its obligations under this Agreement, and Merck will be responsible for ensuring the performance and compliance by such Affiliate or Third Party with the applicable terms this Agreement as if such Affiliate or
Third Party were “Merck” and any [***] as if such Affiliate or Third Party were “Merck”, in each case, to the extent applicable to such Sublicensee; provided, further, that, as a condition precedent to and requirement of any such
sublicense to a Third Party under the foregoing clauses [***]: 
 (i) such sublicense is set forth in a written agreement;

 (ii) Merck will provide Moderna with a copy of any such sublicense agreement and each material amendment thereto within
[***] days of execution thereof, which may be redacted as necessary to protect confidential information and other commercially sensitive information; and 

(iii) such sublicense agreement shall be consistent with and subject to the applicable terms and conditions of this Agreement.

 (b) Moderna Sublicensing. Moderna may grant sublicenses under any of the licenses granted to Moderna by Merck under
Section 10.2 or Section 10.10 or to the Rights of Reference granted under this Agreement (1) to one or more Affiliates (with the right to sublicense through multiple tiers in accordance with this Agreement) without requiring
Merck’s 

  
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prior written consent, (2) to one or more Third Party subcontractors (in accordance with Section 10.4) of Moderna (or its Affiliate) to perform the subcontracted activities, [***];
provided that, [***], the grant of any such sublicense to an Affiliate or Third Party shall not relieve Moderna of its obligations under this Agreement, and Moderna will be responsible for ensuring the performance and compliance by such Affiliate or
Third Party with the applicable terms this Agreement as if such Affiliate or Third Party were “Moderna” and any Included Merck In-License as if such Affiliate or Third Party were “Moderna”, in each case, to the extent applicable
to such Sublicensee; provided, further, that, as a condition precedent to and requirement of any such sublicense to a Third Party under the foregoing clauses [***]: 

(i) such sublicense is set forth in a written agreement; 

(ii) Moderna will provide Merck with a copy of any such sublicense agreement and each material amendment thereto within [***]
days of execution thereof, which may be redacted as necessary to protect confidential information and other commercially sensitive information; and 

(iii) such sublicense agreement shall be consistent with and subject to the applicable terms and conditions of this Agreement.

 10.4 Subcontractors. Each Party may subcontract any of its Research, Development or Manufacturing activities to be
performed hereunder to an Affiliate or, solely with the prior written consent of the other Party (such consent not to be unreasonably withheld), to a Third Party; provided, however, that in all cases, such Party shall ensure that any such Third
Party permitted subcontractor will have entered into a written agreement with such Party that includes terms and conditions protecting and limiting use and disclosure of Confidential Information and Know-How at least to the same extent as under this
Agreement, and such Party shall require any such Affiliate or Third Party and its personnel to assign to such Party all right, title and interest in and to any Patents or Know-How created, conceived or discovered in connection with the performance
of any subcontracted activities; provided, however, that a Party shall be entitled to [***]. Notwithstanding the foregoing, each Party shall be permitted to (x) utilize Third Party permitted subcontractors that are identified on Exhibit
L-1 with respect to such Party, which exhibit lists the identity of the applicable Third Party subcontractor and a description of the activities that such Third Party subcontractor is authorized to perform hereunder and also with respect to
Merck any other Manufacturing Subcontractor, and (y) subcontract or otherwise agree to perform any Development activities to be performed under an Independent Additional Study Development Plan to any Third Party, in each case, without requiring
the prior written consent of the other Party, subject to Section 10.12 and also allowing for customary and reasonable provisions for the treatment of sharing of resulting data and the performance of the Independent Additional Study (other than
to any Third Party that is a direct competitor in the mRNA therapeutic/vaccine field (for example, as of the Amended Effective Date, the Third Parties listed on Exhibit L-2), which subcontract will require such other Party’s prior
written consent, such consent not to be unreasonably withheld, conditioned or delayed) and (z) Merck may subcontract any of its Commercialization activities to be performed hereunder to (1) an Affiliate or (2) a Third Party. Each
Party shall oversee the performance by any of its Affiliate or Third Party permitted subcontractors, and shall remain responsible and primarily liable for the performance of such activities in accordance with this Agreement. Each Party hereby
expressly waives any requirement that the other Party exhaust any right, power or remedy, or proceed against any subcontractor for any obligation or performance hereunder, prior to proceeding directly against the Party engaging the subcontractor.

  
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 10.5 Section 365(n) of the Bankruptcy Code. All rights and licenses
granted under or pursuant to any section of this Agreement, are, and will be deemed to be for all purposes of Section 365(n) of Title 11 of the United States Code and of any similar provisions of applicable Laws under any other jurisdiction
(the “Bankruptcy Code”), rights and licenses to “intellectual property” (as defined in Section 101(35A) of the Bankruptcy Code). Each Party agrees that the other Party, as a licensee of rights and licenses under this
Agreement, will retain and may fully exercise all of its rights and elections under the Bankruptcy Code. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under the Bankruptcy Code or
analogous provisions of applicable Law outside the U.S., the other Party will be entitled to a complete duplicate of, or complete access to (as appropriate), any intellectual property licensed to such other Party held by such first Party and its
successors and assigns (including all embodiments thereof), which, if not already in such other Party’s possession, will be promptly delivered to it (a) upon any such commencement of a bankruptcy proceeding upon such other Party’s
written request therefor, unless such first Party elects to continue to perform all of its obligations under this Agreement, or (b) if not delivered under clause (a), following the rejection of this Agreement by such first Party in the
bankruptcy proceeding upon written request therefor by such other Party. 
 10.6 Third Party In-Licenses. The terms
and conditions for the inclusion and treatment under the Collaboration of Patents and Know-How in-licensed by a Party pursuant to Third Party In-Licenses are set forth on Exhibit F. 

10.7 Moderna Exclusivity. 

(a) [***]  

(i) [***] 

(ii) [***] 

(b) mRNA-PCV Field.  

(i) During the POC Term for the PCV Program, Moderna will not, [***]. 

(ii) During the Merck Participation Term for the PCV Program, Moderna will not, [***]. 

(c) SAV Research Term Exclusivity. During the SAV Research Term, Moderna will not, [***]. 

(d) [***] Exclusivity. 

  
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 (i) On a Joint SAV Program-by-Joint SAV Program basis, during the POC Term for
such Joint SAV Program, [***]. 
 (ii) [***], during the Merck Participation Term for such Joint SAV Program, [***]. 

(iii) [***], during the POC Term and any Merck Participation Term (as applicable) [***]. 

(iv) [***] 

(e) Exception for Business Combination.  

(i) Notwithstanding Sections [***], if a Business Combination occurs with respect to Moderna or its parent Affiliate with a
Third Party, and the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than Moderna and its Affiliates as of the Business Combination) has as of
the Business Combination, or later has, a program (or rights thereto) that would otherwise violate any of [***] “Moderna Business Combination Program”), then [***]; provided that [***]. In addition, upon any such Business
Combination of Moderna or its parent Affiliate, the following shall apply: 
 (1) At Merck’s written election within
[***] after the closing date of such Business Combination of Moderna or its parent Affiliate, [***]; 
 (2) If, within the
period from [***] after the closing of such Business Combination until [***] of such closing, [***]. 
 (ii) In addition to
the other provisions of this Section 10.7(e), Merck shall have the right to [***]. 
 (iii) In addition,
notwithstanding [***], if (A) Moderna or its Affiliate acquires a Third Party (by merger, consolidation or otherwise) so that such Third Party becomes an Affiliate over which Moderna or its Affiliate has control (as defined in
Section 1.13), or (B) Moderna or its Affiliate acquires all or substantially all of the assets of a Third Party (including any subsidiaries or divisions thereof) (each of (A) and (B), a “Moderna Acquisition”), and, in
each case, the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than Moderna and its Affiliates as of the Moderna Acquisition) already has, or the
acquired assets contain, as applicable, a program that existed prior to, or was substantially in the process of being implemented prior to such Moderna Acquisition and is in fact implemented shortly after such Moderna Acquisition, the Moderna
Acquisition that would otherwise violate any of [***] (a “Moderna Acquisition Program”), then Moderna or such Affiliate will, within thirty (30) days after the closing of such Moderna Acquisition, provide written notice to
Merck that Moderna or such Affiliates has rights to a Moderna Acquisition Program as a result of a Moderna Acquisition, which written notice will [***]. Alternatively, [***]. 

  
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 (f) Non-Restricted Activities. 

(i) The Parties hereby acknowledge and agree that Moderna’s obligations under [***] will not apply to any Research,
Development, Manufacture or Commercialization of [***]; provided that Moderna will ensure that during the Collaboration Term for the PCV Program, [***]. 

(ii) The Parties hereby acknowledge and agree that Moderna’s obligations under [***] will not apply to any of
Moderna’s or its Affiliates’ (1) internal Research activities, (2) Research activities with academic collaborators or non-profit institutions, or (3) Non-Commercial Combination Activities, in each case ((1)-(3)) that
[***]; provided that, in each case ((1)-(3)), Moderna will ensure that during the Collaboration Term for a given SAV Program, (A) [***], (B) Merck Confidential Information is [***], (C) Merck Background Technology is [***], and
(D) the licenses granted under Section 10.2(d)(i) or 10.2(d)(ii) shall not be used in the conduct of the above-referenced activities relating to [***]. 

10.8 Merck Exclusivity. 

(a) mRNA-PCV Field.  

(i) During the POC Term for the PCV Program, Merck will not, [***]). 

(ii) During the Merck Participation Term for the PCV Program, Merck will not, [***]. 

(b) SAV Research Term Exclusivity. During the SAV Research Term, [***]. 

(c) [***] Exclusivity. 

(i) [***], during the POC Term for such Joint SAV Program, [***]. 

(ii) [***], during the Merck Participation Term for such Joint SAV Program, [***]. 

(iii) [***], during the POC Term and any Merck Participation Term (as applicable[***]. 

(iv) [***] 

(d) Exception for Business Combination.  

(i) Notwithstanding Section [***], if (i) a Business Combination occurs with respect to Merck or its Affiliate with a
Third Party, and the Third Party (or any of such Third Party’s Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than Merck and its Affiliates as of the Business Combination) has as of the
Business Combination, or later has, a program (or rights thereto) that would otherwise violate any of [***] (each, a “Merck Business Combination Program”), then [***]; provided that [***]. 

  
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 (ii) In addition, notwithstanding Section [***], if (A) Merck or its
Affiliate acquires a Third Party (by merger, consolidation or otherwise) so that such Third Party becomes an Affiliate over which Merck or its Affiliate has control (as defined in Section 1.12), or (B) Merck or its Affiliate acquires all
or substantially all of the assets of a Third Party (including any subsidiaries or divisions thereof) (each of (A) and (B), a “Merck Acquisition”), and, in each case, the Third Party (or any of such Third Party’s
Affiliates or any successors or assigns of such Third Party or such Third Party’s Affiliates, other than Merck and its Affiliates as of the Merck Acquisition) already has, or the acquired assets contain, as applicable, a program that existed
prior to, or was substantially in the process of being implemented prior to such Merck Acquisition and is in fact implemented shortly after such Merck Acquisition, the Merck Acquisition that would otherwise violate any of [***] (a “Merck
Acquisition Program”), then Merck or such Affiliate will, within thirty (30) days after the closing of such Merck Acquisition, provide written notice to Moderna that Merck or such Affiliates has rights to a Merck Acquisition Program as
a result of a Merck Acquisition, which written notice will [***]. Alternatively, [***]. 
 (e) Non-Restricted
Activities.  
 (i) The Parties hereby acknowledge and agree that Merck’s obligations under [***] will not
apply to any Research, Development, Manufacture or Commercialization of [***]; provided that Merck will ensure that during the Collaboration Term for the PCV Program, [***]. 

(ii) The Parties hereby acknowledge and agree that Merck’s obligations under [***] will not apply to any of Merck’s
or its Affiliates’ (1) internal Research activities, (2) Research activities with academic collaborators or non-profit institutions, or (3) Non-Commercial Combination Activities, in each case ((1)-(3)) that [***]; provided
that, in each case ((1)-(3)), Merck will ensure that during the Collaboration Term for a given SAV Program, (A) [***], (B) Moderna Confidential Information is [***], (C) Moderna Background Technology is [***], and (D) the
licenses granted under Section 10.1(d) shall not be used in the conduct of the above-referenced activities relating [***]. 

10.9 No Grant of Inconsistent Rights. Neither Party nor its Affiliates shall assign, transfer, convey or otherwise grant
to any Person or otherwise encumber (including through lien, charge, security interest, mortgage, encumbrance or otherwise, but excluding liens in connection with financings) any rights to any Moderna Technology or Merck Technology (or any rights to
any intellectual property that would otherwise be included in the Moderna Technology or Merck Technology), as applicable, in any manner that is inconsistent with or would interfere with the grant of the rights or licenses to Merck or Moderna
hereunder. For the avoidance of doubt, the Parties understand and agree that the Merck Participation Election right for a given Program, as described herein, shall be [***]. 

10.10 Merck Cessation of Collaboration Activities. Notwithstanding anything to the contrary set forth herein, on a
Program-by-Program basis, at any time during the Merck Participation Term for a given Program, Merck shall have the right, but not the obligation, to elect to cease performance of activities under the Collaboration with respect to such Program upon
delivery of [***] prior written notice to Moderna (each, a “Merck Cessation Election”). Each Merck Cessation Election for a given Program shall clearly identify [***]. Subject to the terms of this Agreement, upon the exercise of a
Merck Cessation Election for a given Program, the following shall apply: 

  
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 (a) The Merck Participation Term, the Collaboration Term and the Collaboration
for such Program shall terminate, and all Collaboration Products from such Program then in existence will be treated thereafter as “PCVs” or “SAVs”, as applicable, under this Agreement (other than [***]). Merck shall no longer
have any licenses or other rights under this Agreement (without limiting the license grants in Section 10.1(d)) to Research, Develop, Manufacture and Commercialize Collaboration Products from such Program under this Agreement. [***] 

(b) Merck will prepare and provide to Moderna a draft plan for the transition of Collaboration Activities with respect to such
Program from Merck to Moderna (a “Cessation Transition Plan”), which Cessation Transition Plan will be reviewed and approved by the Parties. Each Party will use Commercially Reasonable Efforts to perform the obligations assigned to
it under the Cessation Transition Plan in accordance with the timelines set forth therein. 
 (c) The license grants to Merck
under Section 10.1(b) with respect to such Program shall terminate. Each sublicense granted by Merck to any rights licensed to it under Section 10.1(c) with respect to such Program shall terminate. The license grants set forth in
Section 10.1(d) shall continue in full force and effect. 
 (d) The license grants to Moderna under Section 10.2(c)
with respect to such Program shall terminate, and each sublicense granted by Moderna to any rights licensed under Section 10.2(c) shall terminate. Effective as of the date of the Merck Cessation Election for such Program, Merck shall grant, and
hereby does grant (without any further action on the part of either Party), on behalf of itself and its Affiliates, to Moderna a sublicensable (subject to Section 10.3(b)), worldwide, perpetual, irrevocable exclusive license under the Merck
Technology, to Research, Develop, Manufacture and Commercialize the Collaboration Products from such Program in the Territory, and the license grants set forth in Section 10.2(d) shall continue in full force and effect. 

(e) In the event of a Merck Cessation Election for the PCV Program, the exclusivity provisions in Sections [***] shall
terminate for the PCV Program. 
 (f) In the event of a Merck Cessation Election for a given Joint SAV Program, then the
exclusivity provisions in Sections [***] shall terminate with respect to such Joint SAV Program. 
 (g) At Moderna’s
election, Merck will responsibly wind-down, in accordance with accepted pharmaceutical industry norms and ethical practices, any on-going Clinical Studies with respect to Collaboration Products from such Program then in existence in [***] or, if
requested by Moderna, Merck will transfer responsibility for any such Clinical Study to Moderna, in each case in accordance with the Cessation Transition Plan. Merck will be responsible for payment of any costs associated with such wind-down or
transfer. [***]. 

  
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 (h) As promptly as practicable after the date of the Merck Cessation Election for
a given Program, Merck and its Affiliates shall, to the extent Merck and its Affiliates have the right to do so under applicable Law, assign and transfer to Moderna or Moderna’s designee possession and ownership of all material Regulatory
Filings, Regulatory Approvals, all final pre-clinical and Clinical Study reports and clinical study protocols, and all data, including non-clinical and Clinical Data, in each case, in Merck’s possession and Control and to the extent solely
related to Collaboration Products from such Program then in existence. All data and other information shall be transferred in the form and format in which it is maintained by Merck or its Affiliate. Original paper copies shall only be transferred,
if required by applicable Law. Merck and its Affiliates shall not be required to [***]. At Merck’s election, for such Program, Merck shall either [***]. In the event of failure to obtain assignment of any of the items required to be assigned
under this Section 10.10(h), Merck hereby consents and grants to Moderna or its designee the right to access and reference (without any further action required on the part of Merck, whose authorization to file this consent with any Regulatory
Authority is hereby granted) any such item to the extent solely related to Collaboration Products from such Program. 
 (i)
Subject to the terms of the applicable Cessation Transition Plan, Merck and its Affiliates shall [***]. 
 (j) Merck will
promptly transfer and assign to Moderna all of Merck’s and its Affiliates’ rights, title and interests in and to the trademark(s) solely used to identify the Collaboration Products from such Program then in existence (but not any house
marks, or logos or any trademark of Merck or its Affiliates, containing the word “Merck” or any such Affiliate) owned by Merck and used for the Collaboration Products from such Program then in existence. 

(k) Subject to the applicable Cessation Transition Plan, Merck will transfer to Moderna any finished goods inventory of
Collaboration Products from such Program then in existence Controlled by Merck or its Selling Parties as of the date of the Merck Cessation Election for such Program (if any) at cost for such supply. [***] [***] 

(l) For any Collaboration Product from such Program then being Developed in a Clinical Study pursuant to this Agreement in
combination with [***] or any Merck Agent that is commercially available: 
 (i) Merck will grant to Moderna a Right of
Reference [***] to continue the Development of such Collaboration Products from such Program in combination with [***]or such Merck Agent (as applicable) under appropriate Regulatory Filings or Regulatory Approvals. 

(ii) Merck shall supply [***] or such Merck Agent (as applicable) to Moderna in accordance with Exhibit K for further
Clinical Studies of such Collaboration Products from such Program in combination with [***] or such Merck Agent until Regulatory Approval for such Collaboration Product, but in any event [***]. Moderna shall provide Merck with a copy of any data
generated from any such Clinical Study for Merck’s use in connection with [***] or such Merck Agent, and in all cases, if Moderna is conducting a Clinical Study involving [***], the provisions of Section 3.4(m) shall apply mutatis
mutandis. 

  
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 (m) The Parties’ rights and obligations under [***] shall terminate in full
with respect to such Program and the Collaboration Products thereunder (provided that for clarity, this Agreement shall remain in full force and effect for all other Programs and Collaboration Products). [***]. In addition, on a Program-by-Program
basis, if, as of the date of the Merck Cessation Election for such Program, a Party is granting a sublicense to the other Party under an Included In-License for such Program, and such sublicense under such Included In-License survives the Merck
Cessation Election for such Program pursuant to this Section 10.10, then, (i) the Party receiving such sublicense under such Included In-License shall [***] and (ii) such Party’s rights under such Included In-License will be
subject to the terms of such Included In-License; provided that in each case of (i) and (ii), the licensor Party promptly informs the other Party of any [***]. 

(n) [***] 

10.11 [***]. 

(a) [***] 

(b) [***] 

10.12 Exclusion of Agent Intellectual Property. 

(a) Notwithstanding any other provision of this Agreement, “Moderna Background Know-How”, “Moderna Background
Patents”, “Merck Background Know-How” and “Merck Background Patents” shall not include any Know-How, Patents or other rights, and no licenses shall or are granted hereunder, with respect to [***] or any Moderna Agent, Merck
Agent or Third Party Agent, including any Agent Technology, other than [***]. 
 (b) Further, notwithstanding Sections 11.2
through 11.4, [***]. 
 10.13 Supply and Use of Materials; Cooperation. At the reasonable request of the other Party,
a Party will supply the other Party Materials Controlled by such Party for Research consistent with and in furtherance of the POC Plan, Joint Development Plan and Budget or Additional Research Plan for a given Program, as applicable. Each Party will
use any Materials provided by the other Party hereunder only in accordance with the POC Plan, Joint Development Plan and Budget or Additional Research Plan for the applicable Program, and otherwise in accordance with the terms and conditions of this
Agreement (including for clarity in connection with activities conducted by the Parties during the Merck Participation Election Period for a given Program in connection with the Research, Development, Manufacture or Commercialization of the
Collaboration Products from such Program), the use limitations agreed to by the Parties and any reasonable instructions provided by the Party furnishing the Materials. Except with the prior written consent of the supplying Party (such consent not to
be unreasonably withheld, delayed or conditioned), the Party receiving any Materials will not distribute or otherwise allow the release of such Materials to any Third Party, except for subcontracting as permitted hereunder or otherwise in connection
with the Research, Manufacture, Development and Commercialization of Collaboration Products by the Parties hereunder, to the extent consistent with the use limitations agreed to by the Parties. All Materials delivered to the receiving Party will be
used in compliance with all applicable Law. The 

  
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Materials supplied under this Agreement will be used with prudence and appropriate caution in any experimental work because not all of their characteristics may be known. The receiving Party
shall not reverse engineer, reverse compile, disassemble or otherwise attempt to derive the composition or underlying information, structure or ideas of the provider’s Materials, and in particular shall not analyze the provider’s Materials
by physical, chemical or biochemical means except as necessary to perform its obligations under this Agreement. 
  

	11.	 OWNERSHIP OF TECHNOLOGY 

11.1 Disclosure. Subject to Section 6.1(e), each Party will promptly disclose to the other Party in writing, and
will cause its Affiliates and subcontractors to so disclose, the conception, creation or discovery of any Collaboration Know-How. 

11.2 Ownership of Moderna Agent Technology[***]. Subject to the license grants to Merck under this Agreement, as
between the Parties, Moderna will own and retain all right, title and interest in and to all (a) improvements, modifications, developments, enhancements and inventions arising in the performance of activities hereunder from the use of, and
specifically relating to, any Moderna Agent or their use (collectively “Moderna Agent Technology”), [***] conceived, created or discovered during the performance of Collaboration Activities. Accordingly, Merck will promptly disclose
to Moderna in writing, the conception, creation, or the discovery, of any Moderna Agent Technology, [***] by or on behalf of Merck or its Affiliates. Merck, for itself and on behalf of its Affiliates, hereby assigns (and to the extent such
assignment can only be made in the future hereby agrees to assign) to Moderna all its right, title and interest in and to any Moderna Agent Technology, [***]. Merck will cooperate, and will cause the foregoing persons and entities to cooperate, with
Moderna to effectuate and perfect the foregoing ownership, including by promptly executing and recording assignments and other documents consistent with such ownership. 

11.3 Ownership of Merck Agent Technology [***]. Subject to the license grants to Moderna under this Agreement, as
between the Parties, Merck will own and retain all right, title and interest in and to all (a) improvements, modifications, developments, enhancements and inventions arising in the performance of activities hereunder from the use of, and
specifically relating to, Keytruda or any Merck Agent or their use (collectively, “Merck Agent Technology”) [***] conceived, created or discovered during the performance of Collaboration Activities. Accordingly, Moderna will
promptly disclose to Merck in writing, the conception, creation or discovery of any Merck Agent Technology [***] by or on behalf of Moderna or its Affiliates. Moderna, for itself and on behalf of its Affiliates, hereby assigns (and to the extent
such assignment can only be made in the future hereby agrees to assign), to Merck all its right, title and interest in and to any Merck Agent Technology [***]. Moderna will cooperate, and will cause the foregoing persons and entities to cooperate,
with Merck to effectuate and perfect the foregoing ownership, including by promptly executing and recording assignments and other documents consistent with such ownership. 

11.4 Ownership of [***]; Joint Technology. Subject to the license grants by one Party to the other under this Agreement,
as between the Parties, all [***] conceived, created or discovered, by or on behalf of either Party or its Affiliates either alone or jointly with Third Party(ies), or by the Parties or their Affiliates jointly under or in connection with this
Agreement, 

  
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whether or not conceived, created or discovered at a facility owned or controlled by such Party and whether or not patented or patentable (including any and all Patents and other intellectual
property rights with respect thereto), will be owned in accordance with inventorship and in accordance with applicable Law in the United States. For the avoidance of doubt, subject to Section 11.6, and to the license grants in this Agreement,
the Parties will each own an equal, undivided interest in any and all Joint Technology. Each Party will, and does hereby, assign, and will cause its Affiliates and subcontractors to so assign, to the other Party, without additional compensation,
such right, title and interest in and to any Joint Technology as well as any intellectual property rights with respect thereto, as is necessary to fully effect the joint ownership provided for in the foregoing sentence of this Section 11.4.

 11.5 United States Law. The determination of whether Know-How and Patents are conceived, created or discovered by a
Party for the purpose of allocating proprietary rights (including Patent, copyright or other intellectual property rights) therein, in accordance with Section 11.4, will, for purposes of this Agreement, be made in accordance with applicable Law
in the United States. In the event that United States Law does not apply to the conception, creation or discovery of any Know-How or Patents hereunder, each Party will, and does hereby, assign, and will cause its Affiliates to so assign, to the
other Party, without additional compensation, such right, title and interest in and to any Know-How and Patents as well as any intellectual property rights with respect thereto, as is necessary to fully effect ownership as would have been determined
under U.S. Law. 
 11.6 Exploitation of Joint Technology. Each Party will exercise its ownership rights in and to the
Joint Technology, including the right to license and sublicense or otherwise to exploit, transfer or encumber its ownership interest, without an accounting or obligation to, or consent required from, the other Party, but subject to Section 12
and the license grants under this Agreement. At the reasonable written request of a Party, the other Party will in writing grant such consents and confirm that no such accounting is required to effect the foregoing regarding Joint Technology. 

11.7 No Implied Rights. No license, sublicense or other right is or will be created or granted hereunder by implication,
estoppel or otherwise. Any licenses, sublicenses or rights will be granted only as expressly provided in this Agreement. Neither Party nor any of its Affiliates will use or practice any Know-How or Patents licensed or provided to such Party or any
of its Affiliates outside the scope of or otherwise not in compliance with the rights and licenses granted to such Party and its Affiliates under this Agreement. 

11.8 Patent Prosecution, Maintenance and Enforcement. Provisions regarding the Prosecution and Maintenance of Patents,
and enforcement of Patents, are set forth in Exhibit J.  
  

	12.	 CONFIDENTIALITY 

12.1 Confidential Information. 

(a) Confidential Information. Each Party (“Disclosing Party”) may have disclosed or will disclose to
the other Party (“Receiving Party”), and Receiving Party may acquire during the course and conduct of activities under this Agreement, certain proprietary or confidential information of Disclosing Party. The term
“Confidential Information” means (i) all 

  
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proprietary tangible samples of, and confidential information about, Materials and (ii) all confidential ideas and information of any kind, whether in written, oral, graphical,
machine-readable or other form, whether or not marked as confidential or proprietary, which are transferred, disclosed or made available to Receiving Party by Disclosing Party or at the request of Receiving Party. Without limiting the foregoing, all
confidential information about (1) the Moderna Technology will be considered Confidential Information of Moderna, (2) the Merck Technology will be considered Confidential Information of Merck, (3) Joint Technology will be treated as
Confidential Information of both Parties, and (4) the Collaboration Products from a given Program will be treated as Confidential Information of both Parties during the Collaboration Term for such Program. For the avoidance of doubt, the
restrictions and limitations set forth in this Section 12 shall not limit any other restrictions or limitations set forth herein with respect to the use and disclosure of information. 

(b) Restrictions. During the Term and for [***] thereafter, Receiving Party will, and will cause its Affiliates and
their respective officers, directors, employees and agents to, keep all Disclosing Party’s Confidential Information in confidence with the same degree of care with which Receiving Party holds its own confidential information (though no less
than reasonable care). Receiving Party will not use, and will cause its Affiliates and their respective officers, directors, employees and agents not to use, Disclosing Party’s Confidential Information except for in connection with the
performance of its obligations and exercise of its rights under this Agreement. Subject to the terms of this Agreement, Receiving Party has the right to disclose Disclosing Party’s Confidential Information without Disclosing Party’s prior
written consent, to the extent and only to the extent reasonably necessary or useful, to Receiving Party’s Affiliates and their employees, subcontractors, Sublicensees, consultants or agents who have a need to know such Confidential Information
in order to perform its obligations and exercise its rights under this Agreement and who are required to comply with restrictions on use and disclosure similarly restrictive as those in this Section 12.1(b). Receiving Party will use [***] to
cause those entities and persons to comply with such restrictions on use and disclosure. Notwithstanding the foregoing sentence, Receiving Party assumes responsibility for those entities and persons maintaining Disclosing Party’s Confidential
Information in confidence and using same only for the purposes described herein. 
 (c) Exceptions. Receiving
Party’s obligation of nondisclosure and the limitations upon the right to use the Disclosing Party’s Confidential Information set forth in Section 12.1(b) will not apply to the extent that Receiving Party can demonstrate that the
Disclosing Party’s Confidential Information: (i) was known to Receiving Party or any of its Affiliates prior to the time of disclosure; (ii) is or becomes public knowledge through no fault or omission of Receiving Party or any of its
Affiliates; (iii) is obtained by Receiving Party or any of its Affiliates from a Third Party under no obligation of confidentiality to Disclosing Party; or (iv) has been independently developed by employees, subcontractors, consultants or
agents of Receiving Party or any of its Affiliates without the aid, application or use of Disclosing Party’s Confidential Information, as evidenced by contemporaneous written records. Notwithstanding the foregoing, (A) any Confidential
Information will not be deemed to be within the foregoing exceptions merely because such information is embraced by more general information in the public domain or in the possession of the Receiving Party or any of its Affiliates, and (B) any
combination of features will not be deemed to be within the foregoing exceptions merely because individual features are in the public domain or in the possession of the Receiving Party or any of its Affiliates, but only if the combination itself and
its principle of operation are in the public domain or in the possession of the Receiving Party or any of its Affiliates. 

  
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 (d) Permitted Disclosures. Receiving Party may disclose Disclosing
Party’s Confidential Information to the extent (and only to the extent) such disclosure is reasonably necessary in the following instances: 

(i) in order to comply with applicable Law or with a legal or administrative proceeding; 

(ii) in connection with (a) prosecuting or defending litigation or (b) the Prosecution and Maintenance of Patents in
accordance with this Agreement; 
 (iii) in connection with exercising any rights or other licenses under this Agreement,
including [***]; 
 (iv) in the case of Merck, [***]; and 

(v) in the case of Moderna, [***]. 

In the case of a disclosure pursuant to (A) Sections [***], where reasonably possible, Receiving Party will notify Disclosing Party of
Receiving Party’s intent to make any disclosure pursuant thereto sufficiently prior to making such disclosure [***], and (B) with respect to [***], each of those named people and entities are required to comply [***], the Receiving Party
assumes responsibility for those entities and persons maintaining Disclosing Party’s Confidential Information in confidence and using same only for the purposes described herein. 

12.2 Publications. The Parties may desire to publish in scientific journals and present at scientific conferences the
results of the Collaboration Activities, subject to the following process. Notwithstanding anything to the contrary herein, either Party may propose publication of the results of the Collaboration Activities following scientific review by the JSC
(if in force); provided, that no such publication will be made without written approval by Moderna and Merck. After receipt of the proposed publication by both Merck and Moderna, such written approval or disapproval will be provided within
[***] days. Both Parties understand that a reasonable commercial strategy may require delay of publication of information or filing of Patent applications, therefore the Parties agree to review and consider delay of publication and filing of patent
applications under certain circumstances for a reasonably limited period of time. Once publications have been reviewed by each Party and have been approved for publication, the same publications do not have to be provided again to the other Party
for review for a later submission for publication. Expedited reviews for abstracts or poster presentations may be arranged if mutually agreeable to the Parties. Each Party will acknowledge the other Party’s technical, non-financial
contributions in any such publication. 

  
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 12.3 Terms of this Agreement; Publicity. 

(a) Restrictions. The Parties agree that the terms of this Agreement and the Equity Agreement will be treated as
Confidential Information of both Parties, and thus may be disclosed only as permitted by Section 12.1(d). Each Party will also be permitted to disclose the terms of this Agreement and any Supply Agreement (including the exhibits hereto and
thereto), in each case under appropriate confidentiality provisions, on a need to know basis, to a Party’s (and its Affiliates’) existing investors and equity holders and to [***], provided that (1) the disclosing Party agrees to
redact information that it reasonably believes is not relevant to the proposed transaction, and (2) [***]. Except as required by applicable Law, each Party agrees not to issue any press release or public statement disclosing information
relating to this Agreement, the transactions contemplated hereby or any of the terms hereof without the prior written consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned), or as such consent may be
obtained in accordance with Section 12.1(c), or as permitted by Section 12.1(d). 
 (b) Securities Filings; Law.
Each Party acknowledges and agrees that the other Party may submit this Agreement (including for clarity, the Exhibits and Schedules hereto) to the United States Securities and Exchange Commission (the “SEC”) or any other securities
exchange and if a Party does submit this Agreement to the SEC or any other securities exchange, such Party agrees to consult with the other Party with respect to the preparation and submission of, a confidential treatment request for this Agreement.
If a Party is required by applicable Law to make a disclosure of the terms of this Agreement in a filing with or other submission to the SEC or any other securities exchange or otherwise to comply with Law, and (i) such Party has provided
copies of the disclosure to the other Party as far in advance of such filing or other disclosure as is reasonably practicable under the circumstances, (ii) such Party has promptly notified the other Party in writing of such requirement and any
respective timing constraints, and (iii) such Party has given the other Party a reasonable amount of time under the circumstances from the date of notice by such Party of the required disclosure to comment upon, request confidential treatment
or approve such disclosure, then such Party will have the right to make such public disclosure at the time and in the manner reasonably determined by its counsel to be required by Law. [***] 

(c) Press Releases. Neither Party may issue any press release or make any other public announcement or statement
concerning this Agreement, the transactions contemplated hereby or the terms hereof, without the prior written approval of the other Party, except as may be required by applicable Law. In the event either Party (the “Issuing Party”)
desires to issue a press release or other public statement disclosing information relating to this Agreement, the transactions contemplated hereby or the terms hereof, the Issuing Party will provide the other Party (the “Reviewing
Party”) with a copy of the proposed press release or public statement (the “Release”) and seek the Reviewing Party’s prior written consent; provided that no such consent shall be required for press releases or other
public statements required by Law (but the Issuing Party shall still provide the Reviewing Party with a copy of the Release for comment in accordance with this Section 12.3(c)). The Issuing Party will specify with each such Release, taking into
account the urgency of the matter being disclosed, a reasonable period of time within which the Receiving Party may provide any comments on such Release and if the Receiving Party fails to provide any comments during the response period called for
by the Issuing Party, the Reviewing Party will be deemed to have not consented to the issuance of such Release. If the Receiving Party provides any comments, the Parties will consult on such Release and work in good faith to prepare a mutually
acceptable Release. Either Party may subsequently publicly disclose any information previously contained in any Release so consented to. 

  
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 (d) Joint Press Release. The Parties agree to issue the joint press
release in Exhibit I promptly following Antitrust Clearance Date; provided that (i) if either Party reasonably believes that there should be revisions to the form of press release in Exhibit I as a result of events or
circumstances occurring after the Amended Effective Date but prior to the issuance of such press release, then prior to the issuance of the joint press release, the Parties will work in good faith and mutually agree on revisions to the joint press
release in Exhibit I to reflect such events or circumstances and (ii) prior to the issuance of the joint press release in Exhibit I, either Party shall have the right, upon notice to the other Party, to propose revisions to any
quotes from such Party’s personnel in the press release set forth in Exhibit I, and the other Party shall not unreasonably withhold consent to such revisions. 
  

	13.	 REPRESENTATIONS AND WARRANTIES; LIMITATIONS OF LIABILITY; INDEMNIFICATION; COVENANTS

 13.1 Representations and Warranties of Each Party. Each Party represents and warrants to the
other as of the Effective Date and as of the Amended Effective Date that: 
 (a) Such Party is duly organized, validly
existing and in good standing under the laws of the jurisdiction in which it is organized. 
 (b) Such Party (i) has the
legal right and power to enter into this Agreement, to extend the rights granted or to be granted to the other in this Agreement, and to fully perform its obligations hereunder, including to grant the licenses set forth herein, and (ii) has
taken all requisite action on its part to authorize the execution and delivery of this Agreement and the performance of its obligations hereunder. This Agreement has been duly executed and delivered on behalf of such Party, and constitutes a legal,
valid and binding obligation, enforceable against such Party in accordance with its terms, except as may be limited by bankruptcy, insolvency, reorganization or other laws affecting creditors’ rights generally and by general equitable
principles. 
 (c) Neither such Party nor its Affiliates has been debarred or is subject to debarment. Neither it nor its
Affiliates will use in any capacity, in connection with the services to be performed under this Agreement, any person who has been debarred pursuant to Section 306 of the Act, or who is the subject of a conviction described in such section. In
addition, neither it nor its Affiliates has used in any capacity, in connection with any Research or Development activities with respect to the mRNA Technology or any Collaboration Product included hereunder carried out prior to the Amended
Effective Date, any person who has been debarred or was the subject of a conviction described in Section 306 of the Act. Such Party agrees to inform the other Party in writing immediately if it or any person who is performing services under
this Agreement is debarred or is the subject of a conviction described in Section 306 of the Act, or if any action, suit, claim, investigation or legal or administrative proceeding is pending or, to the best of such Party’s or its
Affiliates’ Knowledge, is threatened, relating to the debarment or conviction of such Party or any person performing services under this Agreement. 

(d) All necessary consents, approvals and authorizations of all governmental authorities and other Persons required to be
obtained by such Party to enter into, or perform its obligations under, this Agreement have been obtained. 

  
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 (e) The execution and delivery of this Agreement and the performance of such
Party’s obligations hereunder (i) will not conflict with or violate any requirement of applicable Law or orders of governmental bodies, (ii) do not conflict with, or constitute a default under, any contractual obligation of such Party
and (iii) do not conflict with or violate any provision of the corporate charter, by-laws or other organizational documents of such Party. 

13.2 Additional Representations of Moderna. Moderna represents and warrants to Merck that as of the Effective Date and
the Amended Effective Date; provided, for clarity, that Moderna has made representations and warranties with respect to SAVs solely as of the Amended Effective Date: 

(a) there are no actions, judgments or settlements against or owed by Moderna (or any of its Affiliates) and to Moderna’s
Knowledge, no threatened claims or litigation relating to the Moderna Background Patents and/or Moderna Background Know-How; 

(b) Schedule 1.235 sets forth a true, correct and complete list of Moderna Background Patents and such schedule contains
all application numbers and filing dates, registration numbers and dates, jurisdictions and owners. [***] 
 (c) to
Moderna’s Knowledge (i) all Patents within the Moderna Background Patents have been procured or are being procured from the respective patent offices in accordance with applicable Law, and (ii) the issued Patents within the Moderna
Background Patents are not invalid or unenforceable, in whole or in part; 
 (d) it (and its Affiliates) has not prior to the
Amended Effective Date (i) assigned, transferred or conveyed its right, title and/or interest in Moderna Background Patents or Moderna Background Know-How, or (ii) otherwise granted any rights to any Third Parties that would, in the case
of clauses (i) and/or (ii), conflict with the rights granted to Merck hereunder, and, to Moderna’s Knowledge, there is no unauthorized use, infringement or misappropriation of any Moderna Background Patent or Moderna Background Know-How;

 (e) it or its Affiliate is the sole and exclusive owner of the Moderna Background Patents and Moderna Background Know-How,
all of which are as of the Amended Effective Date free and clear of any liens, charges and encumbrances (excluding those entered into the ordinary course of financing its business), and no other Person has as of the Amended Effective Date any claim
of ownership whatsoever with respect to the Moderna Background Patents and Moderna Background Know-How; 
 (f) [***] 

(g) [***] 

(h) there are no agreements to which Moderna or its Affiliates are a party (including any licenses), granting any licenses or
other rights to (or from) Moderna (or any of its Affiliates) relating to the Research, Development, Manufacture and Commercialization of mRNA Cancer Vaccines (including Collaboration Products) as contemplated hereunder; and 

(i) [***] 

(j) [***] 

  
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 13.3 Additional Representations of Merck. Merck represents and warrants to
Moderna that as of the Effective Date and the Amended Effective Date; provided, for clarity, that Merck has made representations and warranties with respect to SAVs solely as of the Amended Effective Date: 

(a) there are no actions, judgments or settlements against or owed by Merck (or any of its Affiliates) and to Merck’s
Knowledge, no threatened claims or litigation relating to the Merck Background Patents and/or Merck Background Know-How; 

(b) [***] 

(c) [***] 

(d) there are no agreements to which Merck or its Affiliates are a party (including any licenses), granting any licenses or
other rights to (or from) Merck (or any of its Affiliates) relating to the Research, Development, Manufacture or Commercialization of mRNA Cancer Vaccines (including Collaboration Products) as contemplated hereunder. 

13.4 Disclaimers. WITHOUT LIMITING THE RESPECTIVE RIGHTS AND OBLIGATIONS OF THE PARTIES EXPRESSLY SET FORTH HEREIN, EACH
PARTY SPECIFICALLY DISCLAIMS ANY GUARANTEE THAT THE COLLABORATION ACTIVITIES OR ANY MRNA CANCER VACCINE OR COLLABORATION PRODUCT WILL BE SUCCESSFUL, IN WHOLE OR IN PART. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN THIS AGREEMENT OR ANY SUPPLY
AGREEMENT, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED (AND EACH PARTY HEREBY EXPRESSLY DISCLAIMS ANY AND ALL REPRESENTATIONS AND WARRANTIES NOT EXPRESSLY PROVIDED IN THIS AGREEMENT), INCLUDING
WITH RESPECT TO ANY MRNA TECHNOLOGY, MRNA CANCER VACCINE TECHNOLOGY, PATENTS OR KNOW-HOW, MRNA CANCER VACCINES OR COLLABORATION PRODUCTS, INCLUDING WARRANTIES OF VALIDITY OR ENFORCEABILITY OF ANY PATENTS, TITLE, QUALITY, MERCHANTABILITY, FITNESS FOR
A PARTICULAR USE OR PURPOSE, PERFORMANCE, AND NONINFRINGEMENT OF ANY THIRD PARTY PATENTS OR OTHER INTELLECTUAL PROPERTY RIGHTS. 

13.5 No Consequential Damages. NOTWITHSTANDING ANYTHING IN THIS AGREEMENT, EXCEPT FOR DAMAGES DUE TO THE FRAUD OR
WILLFUL MISCONDUCT OR GROSS NEGLIGENCE OF THE LIABLE PARTY, NEITHER PARTY WILL BE LIABLE TO THE OTHER OR ANY THIRD PARTY WITH RESPECT TO ANY SUBJECT MATTER OF THIS AGREEMENT FOR ANY INDIRECT, PUNITIVE, SPECIAL OR CONSEQUENTIAL DAMAGES, EVEN IF SUCH
PARTY HAS BEEN INFORMED OR SHOULD HAVE KNOWN OF THE POSSIBILITY OF SUCH DAMAGES; PROVIDED, THAT THIS SECTION 13.5 WILL NOT APPLY TO THE PARTIES’ INDEMNIFICATION RIGHTS AND OBLIGATIONS UNDER SECTION 13.6. 

  
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 13.6 Indemnification and Liability. 

(a) Indemnification by Merck. Merck will indemnify Moderna, its Affiliates and their respective directors, officers,
employees and agents, and their respective successors, heirs and assigns (collectively, “Moderna Indemnitees”), and defend and save each of them harmless, from and against any and all losses, damages, liabilities, costs and expenses
(including reasonable attorneys’ fees and expenses) (collectively, “Losses”) in connection with any and all suits, investigations, claims or demands of Third Parties (collectively, “Third Party Claims”) arising
from or occurring as a result of: [***], except in each case [***] for those Losses and Third Party Claims for which Moderna has an obligation to indemnify Merck pursuant to Section 13.6(b) (or would have had such Third Party Claim been made
against Merck under this Agreement), as to which Losses each Party will indemnify the other to the extent of their respective liability; provided, that Merck will not be obligated to indemnify Moderna Indemnitees for any Losses or Third Party Claims
to the extent that such Losses or Third Party Claims arise as a result of gross negligence or willful misconduct on the part of a Moderna Indemnitee or breach of this Agreement by Moderna. 

(b) Indemnification by Moderna. Moderna will indemnify Merck, its Affiliates and their respective directors, officers,
employees and agents, and their respective successors, heirs and assigns (collectively, “Merck Indemnitees”), and defend and save each of them harmless, from and against any and all Losses in connection with any and all Third Party
Claims arising from or occurring as a result of: [***] except in each case ((i)-(vii)) for those Losses and Third Party Claims for which Merck has an obligation to indemnify Moderna pursuant to Section 13.6(a) (or would have had such Third
Party Claim been made against Moderna under this Agreement), as to which Losses each Party will indemnify the other to the extent of their respective liability for the Losses; provided, that Moderna will not be obligated to indemnify Merck
Indemnitees for any Losses or Third Party Claims to the extent that such Losses or Third Party Claims arise as a result of gross negligence or willful misconduct on the part of an Merck Indemnitee or breach of this Agreement by Merck. 

(c) Notice of Claim. All indemnification claims provided for in Section 13.6(a) and Section 13.6(b) will be
made solely by such Party to this Agreement (the “Indemnified Party”). The Indemnified Party will promptly notify the indemnifying Party (an “Indemnification Claim Notice”) of any Losses or the discovery of any fact
upon which the Indemnified Party intends to base a request for indemnification under Section 13.6(a) or Section 13.6(b), but in no event will the indemnifying Party be liable for any Losses that result from any delay in providing such
notice. Each Indemnification Claim Notice must contain a description of the claim and the nature and estimated amount of such Loss (to the extent that the nature and amount of such Loss is known at such time). The Indemnified Party will furnish
promptly to the indemnifying Party copies of all papers and official documents received in respect of any Losses and Third Party Claims. Notwithstanding the foregoing, any delay or failure to provide any notices or copies pursuant to this
Section 13.6(c) shall not constitute a waiver or release of, or otherwise limit, the Indemnified Party’s rights to indemnification under this Section 13.6 except to the extent that such delay or failure materially prejudices the
indemnifying Party’s ability to defend against the relevant claims. 

  
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 (d) Defense, Settlement, Cooperation and Expenses. 

(i) At its option, the indemnifying Party may assume the defense of any Third Party Claim by giving written notice to the
Indemnified Party within [***] days after the indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed as an acknowledgment that the
indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor will it constitute a waiver by the indemnifying Party of any defenses it may assert against the Indemnified Party’s claim for
indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party (the indemnifying Party will consult
with the Indemnified Party with respect to a possible conflict of interest of such counsel retained by the indemnifying Party). In the event the indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party will immediately
deliver to the indemnifying Party all original notices and documents (including court papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the defense of a Third Party Claim, except
as provided in Section 13.6(d)(ii), the indemnifying Party will not be liable to the Indemnified Party for any legal costs or expenses subsequently incurred by such Indemnified Party in connection with the analysis, defense or settlement of the
Third Party Claim. [***] 
 (ii) Without limiting Section 13.6(d)(i), any Indemnified Party will be entitled to
participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, that such employment will be at the Indemnified Party’s own cost and expense unless [***]. 

(iii) With respect to any Third Party Claims that relate solely to the payment of money damages in connection with a Third
Party Claim and that will not result in the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified Party in any manner, and as to which the indemnifying Party will
have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, the indemnifying Party will have the sole right to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss, on such
terms as the indemnifying Party, in its sole discretion, will deem appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has assumed the defense of the Third Party Claim in accordance with
Section 13.6(d)(i), the indemnifying Party will have authority to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss provided it obtains the prior written consent of the Indemnified Party (such
consent not to be unreasonably withheld, delayed or conditioned). The indemnifying Party will not be liable for any settlement or other disposition of a Loss by an Indemnified Party that is reached without the prior written consent of the
indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party will admit any liability with respect to or settle, compromise or discharge, any Third Party Claim without
the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld, delayed or conditioned. 

  
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 (iv) If the indemnifying Party chooses to defend or prosecute any Third Party
Claim, the Indemnified Party will, and will cause each other Indemnified Party to, cooperate in the defense or prosecution thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences,
discovery proceedings, hearings, trials and appeals as may be reasonably requested in connection therewith. Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the
Indemnified Party of, records and information that are reasonably relevant to such Third Party Claim, and making Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and
explanation of any material provided hereunder, and the indemnifying Party will reimburse the Indemnified Party for all its reasonable out-of-pocket costs and expenses in connection therewith. 

(v) Except as provided above in this Section 13.6(d), the reasonable and verifiable costs and expenses, including
attorneys’ fees and expenses, incurred by the Indemnified Party in connection with any claim will be reimbursed on a Calendar Quarter basis by the indemnifying Party, without prejudice to the indemnifying Party’s right to contest the
Indemnified Party’s right to indemnification and subject to refund in the event the indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 

13.7 Insurance. Each Party will maintain at its sole cost and expense, an adequate liability insurance or self-insurance
program (including product liability insurance) to protect against potential liabilities and risk arising out of activities to be performed under this Agreement, and any agreement related hereto and upon such terms (including coverages, deductible
limits and self-insured retentions) as are customary in the U.S. pharmaceutical industry, or, if such activities are conducted outside the U.S., as are customary in such country, for the activities to be conducted by such Party under this Agreement.
The coverage limits set forth herein will not create any limitation on a Party’s liability to the other under this Agreement. Each Party shall provide the other Party with written evidence of such insurance upon request. Each Party shall
provide the other Party with written notice at least [***] days prior to the cancellation, non-renewal or material change in such insurance or self-insurance which materially adversely affects the rights of the other Party hereunder. 

13.8 Covenants of Moderna. Moderna hereby covenants that Moderna shall throughout the Term: 

(a) [***] 

(b) [***] 
  

	14.	 TERM AND TERMINATION 

14.1 Term. This Agreement shall commence as of the Effective Date and, unless sooner terminated by mutual written
consent, will continue on a Program-by-Program basis (a) if Merck exercises the Merck Participation Election for such Program, until the date on which both Parties cease Researching, Developing, Manufacturing or Commercializing mRNA Cancer
Vaccines (including the Collaboration Products) from such Program without the intention to resume, and (b) if Merck does not exercise the Merck Participation Election for such Program or 

  
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if Merck exercises the Merck Cessation Election for such Program, until the date on which Moderna and its Affiliates cease Researching, Developing, Manufacturing or Commercializing Financial PCVs
or Financial SAVs, as applicable, with respect to such Program without the intention to resume (each, a “Program Term”). This Agreement shall expire in full upon the later of (i) the end of the SAV Research Term and
(ii) the expiration of all Program Terms (the “Term”). Notwithstanding the foregoing, the Parties shall make an HSR Filing under the Equity Agreement, and this Agreement shall terminate and the Original Agreement shall be
reinstated in full without any amendments or modifications (A) at the election of either Party, immediately upon notice to the other Party, in the event that the FTC or the DOJ obtains a preliminary injunction under the HSR Act against the
Parties to enjoin the transactions contemplated by the Equity Agreement or (B) at the election of either Party, immediately upon notice to the other Party, in the event that the Antitrust Clearance Date has not occurred on or prior to ninety
(90) days after the submission of the HSR Filing. As used herein: (1) “FTC” means the United States Federal Trade Commission, (2) “DOJ” means the Antitrust Division of the United States of America
Department of Justice, and (3) “Antitrust Clearance Date” means the earliest date on which the Parties have actual knowledge that all applicable waiting periods under the HSR Act with respect to the transactions contemplated by
this Agreement have expired or have been terminated. 
 14.2 No Termination; Right to Seek Damages. 

(a) In further consideration of the payments by Merck and the significant contributions by each Party, neither Party shall have
any right to terminate this Agreement except as expressly set forth herein and the Parties hereby agree and acknowledge that the foregoing is reasonable and necessary to protect the legitimate interests of each Party. 

(b) Notwithstanding anything to the contrary in this Agreement (including Sections 14.2(a) and [***]), in addition to all
rights and remedies of the Parties under this Agreement, each Party shall be entitled to seek damages (including reasonable attorneys’ fees and expenses) or other equitable remedies (including pursuant to Section 15.2), at Law or
otherwise, with respect to any material breach of this Agreement by the other Party. 
 14.3 [***]  

14.4 [***] 

14.5 Certain Additional Consequences. For the avoidance of doubt, notwithstanding anything to the contrary contained
herein (other than to the extent of the exclusive licenses granted by Merck to Moderna with respect to Collaboration Products, and without any licenses or other rights in or to any Moderna Technology or Confidential Information of Moderna (except as
set forth in Sections 10.1(b) and 10.1(d))), (i) in the event of a Merck Non-Participation or Merck Cessation Election, in each case, with respect to a given Program, Merck and Affiliates [***]. 

  
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 14.6 Return of Confidential Information. Except as otherwise necessary to
continue exercising any ongoing licenses under this Agreement, with respect to a given Program, upon the Merck Non-Participation, the [***], the Merck Cessation Election, or the end of the Program Term, in each case, with respect to such Program,
the Parties will return (or destroy or erase, as directed by the other Party) all data, files, records and other materials containing or comprising the other Party’s Confidential Information with respect to such Program [***]. In addition,
except as otherwise necessary to continue exercising any ongoing licenses under this Agreement, upon expiration of this Agreement, the Parties will return (or destroy or erase, as directed by the other Party) all data, files, records and other
materials containing or comprising the other Party’s Confidential Information. Notwithstanding the foregoing, (i) in respect of physical embodiments of information, the Parties will be permitted to retain one copy of such data, files,
records, and other materials for non-commercial archival purposes, and (ii) in respect of any information stored electronically or in other non-physical media, it will be sufficient for such Party to procure that access to such information is
restricted to non-commercial archiving purposes only. 
 14.7 Survival. In addition to [***], as applicable, the
following provisions will survive expiration of this Agreement: [***]. Expiration of this Agreement will not relieve the Parties of any liability or obligation which accrued hereunder prior to the effective date of such termination or expiration nor
preclude either Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Agreement. All other rights and obligations will terminate upon expiration of this Agreement. 

 

	15.	 GENERAL PROVISIONS 

15.1 Dispute Resolution. 

(a) Disputes. Disputes of any nature arising under, relating to, or in connection with this Agreement
(“Disputes”) will be resolved pursuant to this Section 15.1. 
 (b) Dispute Escalation. In the event
of a Dispute between the Parties, the Parties will first attempt to resolve such dispute by negotiation and consultation between themselves or the JSC. In the event that such dispute is not resolved on an informal basis within [***] days from
receipt of the written notice of a Dispute, any Party may, by written notice to the other (or with respect to a Dispute arising at the JSC, by the JSC within [***] days after the JSC first considers such Dispute in accordance with
Section 2.4(c)), have such dispute referred to the Executive Officers (or their designee, which designee is required to have decision-making authority on behalf of such Party), who will attempt to resolve such Dispute by negotiation and
consultation for a [***] day period following receipt of such written notice. 
 (c) Full Arbitration. 

(i) In the event the Parties have not resolved such Dispute within [***] of receipt of the written notice referring such
Dispute to the Executive Officers, either Party may at any time after such [***] period submit such Dispute to be finally settled by arbitration administered in accordance with the procedural rules of the American Arbitration Association
(“AAA”) in effect at the time of submission, as modified by this Section 15.1(c). The arbitration will be governed by the Laws of the state of New York. The arbitration will be heard and determined by three (3) arbitrators
who are retired judges or attorneys with at least [***] of relevant experience in the pharmaceutical and biotechnology industry, each of whom will be impartial and independent. Each Party will appoint one (1) arbitrator and the third (3rd) arbitrator will be selected by the two (2) Party-appointed arbitrators, or, failing agreement within [***] following appointment of the second arbitrator, by AAA. Such arbitration will
take place 

  
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in [***]. The arbitration award so given will be a final and binding determination of the dispute, will be fully enforceable in any court of competent jurisdiction, and will not include any
damages expressly prohibited by Section 13.5. Fees, costs and expenses of arbitration are to be divided by the Parties in the following manner: Merck will pay for the arbitrator it chooses, Moderna will pay for the arbitrator it chooses, and
the Parties will share payment for the third arbitrator. Except in a proceeding to enforce the results of the arbitration or as otherwise required by applicable Law, neither Party nor any arbitrator may disclose the existence, content or results of
any arbitration hereunder without the prior written consent of both Parties (each such consent not to be unreasonably withheld, delayed or conditioned). 

(ii) In addition to the foregoing provisions of this Section 15.1(c), in the event that a provision of this Agreement
requires “Special Arbitration”, then the following rules will apply with respect to the Dispute that is subject to Special Arbitration: Within [***] of the appointment of the third (3rd) arbitrator, each Party will submit to
the arbitrators in writing its final proposal for resolving the matter that is the subject of such Dispute (“Dispute Proposal”) and any relevant background information and materials it deems appropriate. In connection with reaching
its decision, the arbitrators may (A) order the Parties to produce any documents or other information that are relevant to the arbitrators’ decision, and (B) if the arbitrators deem it necessary, set a date for a hearing no later than
[***] Business Days (or such other period of time as agreed to by the Parties) after submission of the last Dispute Proposal, to be attended by both Parties with each Party having the right to be represented by counsel of its choice. The arbitrators
will determine which of the two Dispute Proposals submitted by the Parties will prevail in the Special Arbitration in the best interest of the applicable Collaboration Product(s), and will not have authority to render any other substantive decision.
The Dispute Proposal selected by the arbitrators shall be binding on the Parties (and, to the extent such Dispute Proposal amends a Plan or budget for a given Program, such Plan or budget shall be deemed amended to the effect of such selected
Dispute Proposal, as applicable). Such decision will be rendered by the arbitrators no later than [***] Business Days after the later of (x) receipt by the arbitrators of the Parties’ Dispute Proposals as set forth in this
Section 15.1(c), or (y) the conclusion of any hearing conducted pursuant to clause (B) above. The Parties will use diligent efforts to cause the completion of any such arbitration within [***] following the initiating Party’s
written notice to submit the Dispute to Special Arbitration (or such longer period of time as the Parties may mutually agree). 

(d) Injunctive Relief. Notwithstanding the dispute resolution procedures set forth in this Section 15.1, in the
event of an actual or threatened breach of this Agreement, the aggrieved Party may seek provisional equitable relief (including restraining orders, specific performance or other injunctive relief), without first submitting to any dispute resolution
procedures hereunder. 
 (e) Tolling. The Parties agree that all applicable statutes of limitation and time-based
defenses (such as estoppel and laches) will be tolled while the dispute resolution procedures set forth in this Section 15.1 are pending, and the Parties will cooperate in taking all actions reasonably necessary to achieve such a result. 

  
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 15.2 Cumulative Remedies and Irreparable Harm. All rights and remedies of
the Parties hereunder will be cumulative and in addition to all other rights and remedies provided hereunder or available by agreement, at law or otherwise. Each Party acknowledges and agrees that breach of any of the terms or conditions of this
Agreement may cause irreparable harm and damage to the other and that such damage may not be ascertainable in money damages and that as a result thereof the non-breaching Party would be entitled to seek on an interim basis from a court and on a
permanent basis from an arbitral tribunal equitable or injunctive relief restraining any breach or future violation of the terms contained herein by the breaching Party without the necessity of proving actual damages or posting bond. Such right to
equitable relief is in addition to whatever remedies either Party may be entitled to as a matter of law or equity, including money damages. 

15.3 Business Combination. Notwithstanding anything to the contrary herein, in the event of an acquisition of a Party by
a Significant Third Party as part of a Business Combination, then for purposes of this Agreement, [***]. “Significant Third Party” means a Third Party [***]. 

15.4 Relationship of Parties. Nothing in this Agreement is intended or will be deemed to constitute a partnership,
agency, employer-employee or joint venture relationship between the Parties. No Party will incur any debts or make any commitments for the other, except to the extent, if at all, specifically provided herein. There are no express or implied Third
Party beneficiaries hereunder. 
 15.5 Compliance with Law. Each Party will perform or cause to be performed any and
all of its obligations or the exercise of any and all of its rights hereunder in good scientific manner and in compliance with all applicable Law. 

15.6 Force Majeure. Neither Party will be liable to the other for failure of or delay in performing obligations set
forth in this Agreement, and neither will be deemed in breach of such obligations, if such failure or delay is due to natural disasters or any causes reasonably beyond the control of such Party; provided, that the Party affected will promptly notify
the other of the force majeure condition and will exert reasonable efforts to eliminate, cure or overcome any such causes and to resume performance of its obligations as soon as possible. 

15.7 Governing Law. This Agreement will be governed by and construed in accordance with the Laws of the state of New
York, without respect to its conflict of laws rules or principles that might otherwise refer construction or interpretation of this Agreement to the substantive Law of another jurisdiction; provided, that any dispute relating to the scope,
validity, enforceability or infringement of any Patents will be governed by, and construed and enforced in accordance with, the substantive Laws of the jurisdiction in which such Patents apply. The Parties agree to exclude the application to this
Agreement of the United Nations Convention on Contracts for the International Sale of Goods. 
 15.8 Counterparts;
Facsimiles. This Agreement may be executed in one or more counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the same instrument. Facsimile or PDF execution and delivery of this
Agreement by either Party will constitute a legal, valid and binding execution and delivery of this Agreement by such Party. 

15.9 Headings. All headings in this Agreement are for convenience only and will not affect the meaning of any provision
hereof. 

  
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 15.10 Waiver of Rule of Construction. Each Party has had the opportunity
to consult with counsel in connection with the review, drafting and negotiation of this Agreement. Accordingly, the rule of construction that any ambiguity in this Agreement will be construed against the drafting party will not apply. 

15.11 Interpretation. Whenever any provision of this Agreement uses the term “including” (or
“includes”), such term will be deemed to mean “including without limitation” (or “includes without limitations”). “Herein,” “hereby,” “hereunder,” “hereof” and other equivalent
words refer to this Agreement as an entirety and not solely to the particular portion of this Agreement in which any such word is used. Except where the context otherwise requires, whenever used, the singular will include the plural, the plural the
singular, the use of any gender will be applicable to all genders and the word “or” is used in the inclusive sense (and/or). Unless otherwise provided, all references to Sections, Schedules and Exhibits in this Agreement are to Sections,
Schedules and Exhibits of this Agreement. References to any Sections include Sections and subsections that are part of the related Section (e.g., a section numbered “Section 2.1” would be part of “Section 2”, and references to
“Section 2.1” would also refer to material contained in the subsection described as “Section 2.1(a)”). Citations to a statute or regulation will be deemed to mean such statute or regulation and any amendment or supplement thereto
or any replacement thereof. As used herein “$” or “dollars” means United States Dollars. 
 15.12
Binding Effect. This Agreement will inure to the benefit of and be binding upon the Parties, their Affiliates, and their respective lawful successors and assigns. 

15.13 Assignment. 

(a) Generally. This Agreement may not be assigned by either Party, nor may either Party delegate its obligations or
otherwise transfer any licenses granted herein or other rights created by this Agreement, except as expressly permitted hereunder, without the prior written consent of the other Party, which consent will not be unreasonably withheld, delayed or
conditioned; provided, that either Party may assign this Agreement (i) in whole or in part, to an Affiliate (provided that the Party assigning to an Affiliate will remain fully liable for any acts or omissions, including financial liabilities,
of such Affiliate) or (ii) in whole to such Party’s successor in connection with the merger, consolidation, sale of all or substantially all of its assets or that portion of its business pertaining to the subject matter of this Agreement,
or any Business Combination of such Party, in each case, without the consent of the other Party. The rights and obligations of the Parties under this Agreement will be binding upon and inure to the benefit of the successors and permitted assigns of
the Parties, and the name of a Party appearing herein will be deemed to include the name of such Party’s successors and permitted assigns to the extent necessary to carry out the intent of this Section 15.13. Any attempted assignment not
in accordance with this Section 15.13(a) will be void. 
 (b) Additional Confidentiality Procedures. In
the event Moderna or any Affiliate of Moderna that does work hereunder or is in possession of Confidential Information of Merck undergoes a Business Combination, neither Merck nor any Affiliate of Merck shall be required to assign to Moderna any
right, title or interest in or to any [***] conceived, created or discovered following such Business Combination.  

  
 115 

 15.14 Extension to Affiliates. Each Party shall have the right to extend
the rights, licenses, immunities and obligations granted or imposed in this Agreement to one or more of its Affiliates to perform certain activities hereunder. All applicable terms and provisions of this Agreement shall apply to any such
Affiliate to which this Agreement has been extended to the same extent as such terms and provisions apply to such Party. Each Party shall remain fully liable for any acts or omissions, including financial liabilities, of such
Affiliates. To the extent that this Agreement imposes obligations on any Affiliates of a Party, such Party agrees to cause its Affiliates to perform such obligations. 

15.15 Notices. All notices, requests, demands and other communications required or permitted to be given pursuant to
this Agreement will be in writing and will be deemed to have been duly given upon the date of receipt if delivered by hand, recognized international overnight courier, confirmed facsimile transmission, or registered or certified mail, return receipt
requested, postage prepaid to the following addresses or facsimile numbers: 
  

			
	 If to Moderna:
	  	 ModernaTX, Inc.

200 Technology Square
 Cambridge,
MA 02139
 Attention: Chief Executive Officer

		
	 With a copy to:
	  	 ModernaTX, Inc.

200 Technology Square
 Cambridge, MA
02139
 Attention: General Counsel

		
	 If to Merck:
	  	 Merck Sharp & Dohme Corp.

One Merck Drive
 Whitehouse Station, NJ
08889-0100
 Attention: Office of Secretary
 Facsimile No.:
(908) 735-1246

		
	 With a copy to:
	  	 Merck Sharp & Dohme Corp.

2000 Galloping Hill Road
 PO Box 539

Mailstop K-1-4161
 Kenilworth, NJ 07033-1310

Attention: Senior Vice President, Business Development

 Either Party may change its designated address and facsimile number by notice to the other Party in the
manner provided in this Section 15.15. 
 15.16 Amendment and Waiver. This Agreement may be amended,
supplemented, or otherwise modified only by means of a written instrument signed by both Parties; provided, that any unilateral undertaking or waiver made by one Party in favor of the other will be enforceable if undertaken in a writing
signed by the Party to be charged with the undertaking or waiver. Any waiver of any rights or failure to act in a specific instance will relate only to such instance and will not be construed as an agreement to waive any rights or fail to act in any
other instance, whether or not similar. 

  
 116 

 15.17 Severability. In the event that any provision of this Agreement
will, for any reason, be held to be invalid or unenforceable in any respect, and if the rights or obligations of either Party under this Agreement will not be materially and adversely affected thereby, (a) such provisions will be given no
effect by the Parties and will not form part of this Agreement, (b) all other provisions of this Agreement will remain in full force and effect, and (c) the Parties will negotiate in good faith to modify this Agreement to preserve (to the
extent possible) their original intent. 
 15.18 Entire Agreement. This Agreement, together with any other agreement
executed or to be executed in connection herewith, including the Equity Agreement, Supply Agreements, Quality Agreements, Co-Promotion Agreements (if any), POC Pharmacovigilance Agreement and the Pharmacovigilance Agreement, sets forth the complete,
final and exclusive agreement with respect to the subject matter hereof and supersedes all other agreements and understandings between the Parties with respect to the subject matter hereof (including the Mutual Confidential Disclosure Agreement
(dated February 27, 2013, as amended on December 10, 2015)) as it relates to cancer vaccines using mRNA. For the avoidance of doubt, this Agreement and the transactions contemplated hereby do not amend, restate, supplement or otherwise
modify any of the terms or conditions of any other agreement between the Parties, including the 2015 Collaboration Agreement, the 2016 CSA and any other agreements entered into pursuant to the 2015 Collaboration Agreement or 2016 CSA. The 2015
Collaboration Agreement and the 2016 CSA shall remain in full force and effect in accordance with their respective terms and conditions. 

15.19 HSR Act. Each of Merck and Moderna shall prior to the election of any rights set forth in Section 3.5(c) if
legally required submit to the United States Federal Trade Commission and the Antitrust Division of the United States Department of Justice, any HSR Filing required of it under the HSR Act, which forms shall specifically request early termination of
the initial HSR Act waiting period; provided further that each of Merck and Moderna shall, prior to the election of any rights set forth in Section 3.5(c) if legally required, make any other applicable competition or antitrust law filing with
any other governmental authority (“ex-U.S. Antitrust Filing”). The Parties will cooperate with one another to the extent necessary in the preparation of any such HSR Filing and ex-U.S. Antitrust Filing. The Parties hereto commit to
instruct their respective counsel to cooperate with each other and use good faith, diligent efforts to facilitate and expedite the identification and resolution of any such issues and, consequently, the expiration of the applicable HSR Act waiting
period or applicable clearances or approvals under any other applicable non-U.S. antitrust or competition law, such good faith diligent efforts to include counsel’s undertaking: (i) to keep each other appropriately informed of
communications received from and submitted to personnel of the reviewing antitrust authority; and (ii) to confer with each other regarding appropriate contacts with and response to personnel of the United States Federal Trade Commission and the
Antitrust Division of the United States Department of Justice or other applicable competition or antitrust governmental authority. Each Party will be responsible for its own costs, expenses and filing fees associated with any HSR Filing or other
ex-U.S. Antitrust Filing. In respect of any HSR Filing or ex-U.S. Antitrust Filing, each of Merck and Moderna will use its good faith, diligent efforts to eliminate any concern on the part of any 

  
 117 

 
court or governmental authority regarding the legality of the proposed transaction, including cooperating in good faith with any government investigation and the prompt production of documents,
information and witnesses requested in the course of any such investigation, including those contained in a Request for Additional Information and Documentary Materials (as that term is defined in the HSR Act) or equivalent legal requirements under
any other non-U.S. competition or antitrust law. Nothing in this Section shall require either Party to consent to the divestiture or other disposition of any of its or its Affiliates’ assets or to consent to any other structural or conduct
remedy, and each Party and its Affiliates shall have no obligation to contest, administratively or in court, any ruling, order or other action of the United States Federal Trade Commission and the Antitrust Division of the United States Department
of Justice, any non-US antitrust or competition law authority or any Third Party respecting the transactions contemplated by this Agreement. The Parties shall not make any election described in Section 3.5(c) of this Agreement until all
applicable competition or antitrust approvals, clearances or decision (including under the HSR Act and any other applicable competition or antitrust laws) are obtained or any applicable waiting periods have expired or terminated. 

[Remainder of this Page Intentionally Left Blank] 

  
 118 

 IN WITNESS WHEREOF, the Parties have caused this Amended and Restated mRNA Cancer
Vaccine Collaboration and License Agreement to be executed by their respective duly authorized officers as of the Amended Effective Date. 
  

			
	MODERNATX, INC.
		
	By:	 	/s/ Stéphane Bancel
		 	 (Signature)

	Name:	 	 Stéphane Bancel

	 Title:
	 	 CEO

  

			
	MERCK SHARP & DOHME CORP.
		
	By:	 	/s/ Benjamin Thorner
		 	 (Signature)

	Name:	 	 Benjamin Thorner

	Title:	 	 SVP & Head of BD&L

 EXHIBIT A-1 

POC Plan for PCV Program 
 [***]

  
 A-1 

 EXHIBIT A-2 

POC Plan for KRAS Program 

[***] 
  

			
	 [***]
	  	 [***]

	 [***]
	  	 [***]

	 [***]
	  	 [***]

 [***] 
  

			
	 [***]

	 [***]
	  	
	 [***]
	  	
	 [***]
	  	 [***]

	 •  [***]
	  	 •   [***]

	 •   [***]
	  	 •   [***]

	 •   [***]
	  	 [***]

	 [***]
	  	 [***]

	 •   [***]
	  	 •  [***]

	 •   [***]
	  	 •   [***]

	 •  [***]
	  	 •   [***]

	 •  [***]
	  	 •   [***]

 [***] 

  
 A-1 

 EXHIBIT A-3 

Research Plan for [***] 
 [***]

  
 A-1 

 EXHIBIT B 

Financial Definitions 

“Additional Regulatory Costs” means costs incurred: [***]. 
  

	 	a)	 “Allowable Commercialization Costs” means the internal costs (i.e. FTE Costs) and
Out-of-Pocket Costs actually incurred by or on behalf of a Party or its Affiliates or Sublicensees, that are [***] including [***]: [***] 

  

	 	b)	 [***] 

  

	 	c)	 [***] 

  

	 	d)	 [***] 

  

	 	e)	 [***] 

  

	 	f)	 [***] 

  

	 	g)	 [***], 

in each case (except in the case of [***] to the extent such costs are consistent with, during the Merck Participation Term for a given Joint
SAV Program or the PCV Program, the Global Commercialization Plan and the Global Commercialization Budget for such Joint SAV Program or the PCV Program or otherwise approved by the JSC, plus Permitted Overages. [***]The Parties agree that Allowable
Commercialization Costs will not include costs or expenses of a Party or its Affiliates or Sublicensees to the extent: [***]. 
 No expense
included in an Allowable Commercialization Cost shall also be included in other costs in the calculations of Moderna Net Profits or Cash Profits or Losses. 

“Allowable Development Costs” means, with respect to a Joint Development Plan and Budget, or Additional Research Plan, in
each case for a given Joint SAV Program or the PCV Program, the Development Costs actually incurred by or on behalf of a Party or its Affiliates or Sublicensees with respect to such Joint Development Plan and Budget or Additional Research Plan that
are consistent with the applicable budget [***] or otherwise approved by the JSC, plus Permitted Overages. Allowable Development Costs shall not include costs or expenses of a Party or its Affiliates or Sublicensees to the extent: [***]. 

“Cash Profits or Losses” has the meaning set forth in Exhibit D. In the case where Cash Profits or Losses is positive,
it shall be referred to as “Cash Profits”, and in the case where Cash Profits or Losses is negative, it shall be referred to as “Cash Losses”. 

“Commercial Liabilities” means, on a country-by-country basis, any Losses incurred by or on behalf of a Party or its
Affiliates or Sublicensees in connection with a Third Party Claim in connection with the Research, Development, Commercialization or Manufacture of a Collaboration Product, including [***]. For purposes of Exhibit E, Commercial Liabilities
shall also apply to Losses incurred by or on behalf of Moderna or its Affiliates or Sublicensees mutatis mutandis with respect to each Financial PCV or Financial SAV, as applicable. 

“Cost of Goods Sold” with respect to each mRNA Cancer Vaccine (including a Collaboration Product), means [***].
Notwithstanding the foregoing, with respect to each mRNA Cancer Vaccine (including a Collaboration Product), to the extent there [***]. 

  
 B-2 

 “Credit Against Profits Mechanism” means each mechanism detailed in
(a) Paragraph 4 of Section B of Exhibit D, with respect to the Profit & Loss Share and (b) Paragraph 11 of Exhibit E, with respect to the Non-Participation PCV Net Profit Share, Non-Participation SAV Net
Profit Share, PCV Cessation Net Profit Share or SAV Cessation Net Profit Share, as applicable. 
 “Development Costs” means
all internal costs (i.e. FTE Costs) and Out-of-Pocket Costs actually incurred by or on behalf of a Party (or its Affiliates or Sublicensees) and that [***], to the extent set forth in the budget within the Additional Research Plan, the Joint
Development Plan and Budget or an Independent Additional Study Development Plan, in each case for a given Joint SAV Program or the PCV Program, including: 
  

	 	(a)	 [***] 

  

	 	(b)	 [***] 

  

	 	(c)	 [***] 

  

	 	(d)	 [***] 

  

	 	(e)	 [***] 

  

	 	(f)	 [***] 

(g) those Patent and Trademark Expenses incurred for the Prosecution and Maintenance of Patents (which shall not be subject to
the budget requirements above); 
 (h) [***] 

[***]With respect to the foregoing, any internal costs shall be calculated based on the number of FTEs used to perform the applicable activity
multiplied by the FTE Rate. For purposes of Exhibit E, Development Costs shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees mutatis mutandis with respect to each Financial PCV or Financial
SAV, as applicable. 
 “Direct Marketing Expenses” means all internal costs (i.e. FTE Costs) and Out-of-Pocket Costs
actually incurred by or on behalf of a Party [***]: 
  

	 	(a)	 [***] 

  

	 	(b)	 [***] 

  

	 	(c)	 [***] 

  

	 	(d)	 [***] 

  

	 	(e)	 [***] 

  

	 	(f)	 [***] 

  

	 	(g)	 [***] 

  

	 	(h)	 [***] 

  

	 	(i)	 [***] 

  

	 	(j)	 [***] 

  

	 	(k)	 [***] 

  
 B-3 

	 	(l)	 [***] 

  

	 	(m)	 [***] 

  

	 	(n)	 [***] 

  

	 	(o)	 [***] 

  

	 	(p)	 [***] 

  

	 	(q)	 [***] 

  

	 	(r)	 [***] 

Direct Marketing Expenses shall not include any Selling Expenses and the costs of activities that promote a Party’s business as a whole
without being product specific (e.g., corporate image advertising). For purposes of Exhibit E, Direct Marketing Expenses shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees mutatis
mutandis with respect to each Financial PCV or Financial SAV, as applicable. 
 “Distribution Expenses” with respect to
each Collaboration Product, means [***]. For purposes of Exhibit E, Distribution Expenses shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees mutatis mutandis with respect to each Financial
PCV or Financial SAV, as applicable. 
 “Financial PCV” means [***].  

“Financial SAV” means, [***]. 

“Gross Profit” means, with respect to a Collaboration Product, Net Sales of a Collaboration Product less Cost of Goods Sold
for such Collaboration Product. For purposes of Exhibit E, Gross Profit shall apply mutatis mutandis with respect to each Financial PCV or Financial SAV, as applicable. 

“IAS Costs” means Development Costs incurred with respect to any Independent Additional Study for a Collaboration Product
subject to the applicable Independent Additional Study Plan. 
 [***] 

[***] 
 [***] 

“Indirect Marketing Expenses” with respect to each Collaboration Product, means [***]. For purposes of Exhibit E,
Indirect Marketing Expenses shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees with respect to each Financial PCV or Financial SAV, as applicable, mutatis mutandis. 

[***] 
 [***] 

  
 B-4 

 “Manufacturing Costs” shall consist of “U.S. GAAP Standard Cost” and
“Product Specific Manufacturing Variances” as defined below. Notwithstanding the foregoing, for purposes of Exhibit D and Exhibit E as used in Cost of Goods Sold, Manufacturing Costs will not include [***]. For purposes of
Exhibit E, Manufacturing Costs shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees with respect to each Financial PCV or Financial SAV, as applicable, mutatis mutandis. 

“Medical Affairs Costs” means all internal costs (i.e. FTE Costs) and Out-of-Pocket Costs actually incurred by or on
behalf of a Party [***]. For purposes of Exhibit E, Medical Affairs Costs shall also apply to costs incurred by or on behalf of Moderna or its Affiliates or Sublicensees with respect to each Financial PCV or Financial SAV, as applicable,
mutatis mutandis. 
 [***] 
 “Merck
Reimbursement Cap” has the meaning set forth in Exhibit E. 
 “Moderna Commercialization Costs” means, on a
Program-by-Program basis for a given Joint SAV Program or the PCV Program, all Shared Commercialization and Related Manufacturing Costs [***], including [***]. All provisions and principles set forth in the definition of Allowable Commercialization
Costs and [***] shall apply to Moderna Commercialization Costs, mutatis mutandis. 
 “Moderna Costs Report” has the meaning set
forth in Exhibit E. 
 “Moderna Development Costs” means, on a Program-by-Program basis for a given Joint SAV
Program or the PCV Program, all Shared Development and Related Manufacturing Costs [***], including [***]. All provisions and principles set forth in the definition of Allowable Development Costs and [***] shall apply to Moderna Development Costs,
mutatis mutandis. 
 “Moderna Net Profits” means, with respect to Financial PCVs or Financial SAV, as applicable,
Gross Profits from such Financial PCVs or Financial SAV, as applicable, less the Moderna Commercialization Costs and Moderna Development Costs for such Financial PCVs or Financial SAV, as applicable. For clarity, costs that are included in one
category of costs shall not be deducted a second time in calculating any other costs that are deducted in calculating Moderna Net Profits. 
 [***] 

“Non-Participation PCV Net Profit Share” shall have the meaning set forth in Exhibit E. 

“Non-Participation SAV Net Profit Share” shall have the meaning set forth in Exhibit E. 

“Other Operating Income/Expense” means the following items, [***]: 
  

	(a)	 [***] 

  

	(b)	 [***] 

  
 B-5 

	 	(c)	 [***] 

  

	 	(d)	 [***] 

  

	 	(e)	 [***] 

  

	 	(f)	 [***] 

  

	 	(g)	 [***] 

“Out-of-Pocket Costs” means costs and expenses paid to Third Parties by or on behalf of Moderna or its Affiliates or
Sublicensees or Merck or its Affiliates or Sublicensees [***] in accordance with the budget set forth in, the POC Plans (including POC Capacity PCV Buildup Plan), Development Plan(s), Additional Research Plans, Global Commercialization Plan(s),
Incremental Capacity Buildup Plans or Commercial Capacity Buildup Plans, as applicable. 
 “Patent and Trademark Expenses”
means the reasonable, documented, out of pocket fees and expenses of outside counsel [***], and filing and maintenance expenses, [***] incurred in connection with (i) the Prosecution and Maintenance of [***]; and (ii) any trademark
applications or registered trademarks used in connection with the Commercialization of any Collaboration Product, including [***]. For purposes of Exhibit E, Patent and Trademark Expenses shall also apply to costs incurred by or on behalf of
Moderna or its Affiliates or Sublicensees mutatis mutandis with respect to each Financial PCV or Financial SAV, as applicable. 
 “PCV
Cessation Net Profit Share” has the meaning set forth in Exhibit E. 
 [***] 

“Product Specific Manufacturing Variances” means [***]. 

“Profitability Date” means, with respect to a given Joint SAV Program or the PCV Program, the last day of the Calendar
Quarter during which the quarterly Cash Profits or Losses (as defined in Exhibit D) from such Program are positive (i.e., greater than zero, [***] or the Moderna Net Profits for such Program are positive (i.e., greater than
zero), as applicable. 
 [***] 
 “Reconciliation
Report” has the meaning set forth in Exhibit D. 
 “SAV Cessation Net Profit Share” has the meaning set forth in Exhibit
E. 
 “Selling Expenses” means, with respect to a Collaboration Product, all costs and expenses associated with [***]. 

“Shared Commercialization and Related Manufacturing Costs” means Allowable Commercialization Costs and [***]. 

  
 B-6 

 “Shared Collaboration Costs” means the Shared Development and Related
Manufacturing Costs and the Shared Commercialization and Related Manufacturing Costs. 
 “Shared Costs Report” has the
meaning set forth in Exhibit D. 
 “Shared Development and Related Manufacturing Costs” means Allowable Development
Costs and [***]. 
 “Shared Profits or Losses” has the meaning set forth in Exhibit D. In the case where Shared
Profits or Losses is positive, it shall be referred to as “Shared Profits”, and in the case where Shared Profits or Losses is negative, it shall be referred to as “Shared Losses”. 

“Sublicensee” as used in this Exhibit B, and Exhibit D and Exhibit E, means [***]. 

“Testing Costs” means the costs that are [***]. For purposes of Exhibit E, Testing Costs shall apply to costs incurred
by or on behalf of Moderna or its Affiliates or Sublicensees with respect to each Financial PCV or Financial SAV, as applicable, mutatis mutandis. 

“U.S. GAAP Standard Cost” means, if applicable, the following with respect to such product: 

 

	 	(a)	 [***] 

  

	 	(b)	 [***] 

  

	 	(c)	 [***] 

  

	 	(i)	 [***] 

  

	 	(ii)	 [***] 

  

	 	(iii)	 [***] 

  

	 	(iv)	 [***] 

	 	(v)	 [***] 

  

	 	(vi)	 [***] 

  

	 	(vii)	 [***] 

  

	 	(viii)	 [***] 

  

	 	(ix)	 [***] 

  

	 	(d)	 [***] 

  

	 	(i)	 [***] 

  

	 	(ii)	 [***] 

  

	 	(iii)	 [***] 

  

	 	(iv)	 [***] 

	 	(v)	 [***] 

  

	 	(vi)	 [***] 

  

	 	(vii)	 [***] 

  

	 	(viii)	 [***] 

  

	 	(ix)	 [***] 

[***] 

The U.S. GAAP Standard Cost will be established each Calendar Year for the upcoming year according to the forecast for
requirements for such product. 

  
 B-7 

 EXHIBIT C 

Relative Commercial Value 

If a Selling Party intends to sell a Combination Product, then the following shall apply: 

1. With respect to sales of Combination Products, Net Sales shall be calculated on a country-by-country basis as follows: 

 

							
		 	 [***]
	  	 [***]
	  	
				
	             
	 	 [***]
	  	 [***]
	  	
				
		 	 [***]
	  	 [***]
	  	

  

	 	2.	 [***] 

  

	 	3.	 [***] 

(a) The Parties shall meet approximately [***] prior to the anticipated First Commercial Sale of such Combination Product in
the Territory to negotiate in good faith and agree to [***] (the “Relative Commercial Value”). [***] 
  

	 	(b)	 [***]. 

  
 C-1 

 EXHIBIT D 

Exercise of Merck Participation Election – Profit & Loss Share 

This Exhibit D to the Agreement covers financial planning, accounting policies and procedures to be followed in
determining the Profit & Loss Share and the cost sharing between the Parties. The Profit & Loss Share shall be calculated on a Program-by-Program basis for a given Joint SAV Program or the PCV Program. The Profit & Loss
Share is not a legal entity and has been defined for identification purposes only.  
 A. Profit & Loss Share

  

	1.	 Principles of Reporting. 

1.1 The presentation of results of operations of the Parties will include each of the following line items (as each is
defined in Exhibit B or elsewhere in the Agreement) be based on each Party’s respective financial information presented separately and on a consolidated basis in the reporting format depicted as follows (the
“P&L”): 
  

							
		  	 [***]
	  	 [***]
	  	 [***]

	 [***]
	  		  		  	
	 [***]
	  		  		  	
	 [***]
	  		  		  	
	 [***]
	  		  		  	
	 [***]
	  		  		  	
	 [***]
	  		  		  	
	 [***]
	  		  		  	

 1.2 Effect of Commercial Grants. 

1.2.1 In connection with a Commercial Grant: (a) such Third Party receiving the Commercial Grant [***], and
(b) Sublicense Income received by such Party and its Affiliates from such Third Party will [***], unless [***]. 

1.2.2 The treatment of a Commercial Grant under [***] pursuant to the foregoing Paragraph 1.2.1 of this Section A of
Exhibit D with respect to Commercial Grants by a Party or any of its Affiliates in [***] will require the prior written consent of the other Party, [***]. 

1.2.3 Any Commercial Grant may include rights to Manufacture and Develop to support Commercialization in the country(ies) of
such Commercial Grant, but the Parties do not intend for Commercial Grants to be used to Develop or Manufacture the applicable Collaboration Product(s) more generally. 

  
 D-1 

 1.3 It is the intention of the Parties to interpret definitions to be consistent
with this Exhibit D and GAAP (except for Cost of Goods Sold given the exclusion of depreciation of certain assets in the calculation of Manufacturing Costs). Where costs included in the foregoing calculation are determined based on either
Party’s system of cost or project accounting, each Party agrees to provide reasonable supporting documentation, as may be requested by the other Party, to ensure that each Party’s methodologies are reasonable and consistently applied. To
the extent that such costs are not readily determinable based on the respective Party’s system of cost or project accounting, the JSC will develop a reasonable methodology for determining such costs. Reasonable methodologies may include a
standard rate or some other appropriate basis for allocating costs. For reconciliation, billing and reporting hereunder, any costs included in the P&L incurred in a currency other than U.S. dollars will be translated into U.S. dollars in
accordance with Section 9.5(e) of the Agreement. 
 1.4 If necessary, a Party will make the appropriate
adjustments to the financial information it supplies under this Exhibit D to conform to the above format of reporting results of operation. 

1.5 Principles: 

1.5.1 In calculating the revenues and costs in this Exhibit D, the following principles shall apply: 

(a) There shall be no double counting of any costs or expenses or of any revenues, and to the extent a cost or expense has
been included in one category or sub-category, it shall not be included in another; similarly, to the extent any revenue has been taken into account in one category or sub-category it shall not be taken into account in another. 

(b) To the extent an item of income or revenue is received by a Party or a cost or expense is incurred in a given Calendar
Quarter by a Party, and can be demonstrated [***]. 
 (c) To the extent any cost by a Party has applicability to both
the Collaboration Product and to any other product, a portion of such costs will be [***] allocated by such Party to the Collaboration Product in good faith; provided the other Party shall have the right to dispute such allocation in good faith and
request additional information prior to including such cost as a Shared Collaboration Cost under this Exhibit D. In addition, to the extent any cost by a Party has applicability to more than one Program, a portion of such costs will be [***]
allocated by such Party to each applicable Program in good faith; provided the other Party shall have the right to dispute such allocation in good faith and request additional information prior to including such cost as a Shared Collaboration Cost
for the applicable Program under this Exhibit D. 
 (d) All costs and expenses shall be determined, and all
calculations shall be made, in accordance with GAAP, as applicable, and consistent with the Parties internal cost allocation practices used in connection with pharmaceutical products owned or controlled solely by each Party without requirement to
share profits or significant royalties with any Third Party, and further consistent with the same policies and principles as it utilizes consistently within its group and business units when making internal cost allocations. 

  
 D-2 

 Without limiting the foregoing, if either Party in good faith believes that the
methodology set forth herein does not accurately reflect the revenues and costs for a Collaboration Product, Program or otherwise for the Collaboration, upon request of such Party, the Parties shall in good faith discuss such concerns and, if the
Parties mutually agree upon acceptable revisions to the methodologies set forth herein, they shall amend Exhibit B, Exhibit D or Exhibit E, as appropriate. For clarity, the foregoing principles shall also apply to the costs and
expenses calculated in Exhibit E mutatis mutandis. 
  

	2.	 Cash Profits or Losses and Shared Collaboration Costs. 

2.1 If Merck elects the Merck Participation Election for a given Program, each Party is entitled to fifty percent
(50%) of the Cash Profits or Losses from such Program for a given [***] subject to this Exhibit D. 

2.2 Certain Exclusions from Shared Collaboration Costs. To the extent any Manufacturing Costs are incurred by a
Party due to [***] by such Party, then such Manufacturing Costs shall be borne solely by such Party and shall not be included in Cost of Goods Sold to be included in the Shared Costs Report hereunder.  

3. Audits. The record keeping and audit provisions set forth in Section 9.5(c) of the Agreement will apply with respect to all
amounts payable by either Party to the other Party under the Profit & Loss Share. 
 4. Reporting of Shared Costs. Within
[***] days after the end of [***], each Party shall provide the other Party with a detailed activity-based summary statement (with supporting documentation [***] of the Shared Collaboration Costs and Costs of Goods Sold incurred by or on behalf of
such Party (or its Affiliate or Sublicensee) in such [***], as applicable (each, a “Shared Costs Report”). [***] 
 5.
Reporting of Net Sales. On a [***] basis, Merck will provide to Moderna an estimate of gross sales and Net Sales of such Collaboration Product in U.S. dollars during the prior [***] and units of such Collaboration Product sold during such
period according to Merck’s sales reporting system, which will be consistent with the financial planning, accounting and reporting procedures set forth in this Exhibit D. Each such report will be provided as early as possible, but no
later than [***] days after the last day of the [***] in question, and will separately provide [***] figures. The Parties understand that all Net Sales of Collaboration Products will be booked in accordance with GAAP and otherwise in accordance with
the definition of Net Sales. 
 6. Reconciliation. Subject to the remainder of this Exhibit D, within [***] days after the end
of [***], each Party will provide to the other a written report setting forth the calculations of aggregate Net Sales and aggregate costs under the Shared Costs Report for such [***] received or funded by such Party. Within [***] days after receipt
of such reports, the Parties will agree on a consolidated written report (the “Reconciliation Report”) setting forth the calculations of each Party’s share of such aggregate Net Sales and aggregate costs under the Shared Costs
Report and the net amount that would be owed from one Party to the other Party to effectuate, subject to Paragraph 6.1 of this Section A of Exhibit D, an equal share of the resulting Cash Profits or Losses between the Parties. Such net
amount would then be adjusted in accordance with Paragraph 17 of Section B of this Exhibit D. 

  
 D-3 

 6.1 [***] 

[***] 
  

									
	 [***]
	  	 [***]

	 	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
		  	  
	 	  
	 	  
	 	  

	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
		  	  
	 	  
	 	  
	 	  

	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
		  	  
	 	  
	 	  
	 	  

	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  		 		 		 	
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
	 [***]
	  	[***]	 	[***]	 	[***]	 	[***]
		  	  
	 	  
	 	  
	 	  

 7. Payment. Any undisputed net payment owed from one Party to the other Party in order for the Parties
to share equally all such costs in the Shared Costs Report, other than [***], shall be paid within [***] days following completion of such Reconciliation Report and an invoice therefor [***]; provided, that [***]. 

8. Budgets and Overages. Each Party shall use Commercially Reasonable Efforts to ensure that the actual costs associated with the
performance of activities allocated to it in the Additional Research Plan, Joint Development Plan and Budget, Global Commercialization Plan, Incremental Capacity Buildup Plan and Commercial Capacity Buildup Plan (if applicable), in each case for the
applicable Program, in a Calendar Year do not exceed [***] of the budgeted costs allocated to such Party for such Calendar Year as set forth in the budget for each applicable plan. Costs for the performance of all activities described in the
applicable plan and budget and allocated to a given Party that exceed the estimated allocated costs therefor as set forth in the budget by up to [***] shall be referred to herein as the “Permitted Overage”, and such costs shall be
included as Shared Development and Related Manufacturing Costs or Shared Commercialization and Related Manufacturing Costs, as applicable. If either Party believes that the actual costs in relation to its activities allocated to a given Party in a
Calendar Year will exceed the allocated budget as set forth in the applicable plan and budget (plus the Permitted Overage) for all such activities allocated to such Party during such Calendar Year, such Party may request the JSC to review and
approve such activities and the costs thereof before undertaking such excess cost. In the event that the JSC does not approve an increase in the 

  
 D-4 

 
budget for such activity, then [***]. For clarity, any costs incurred by or on behalf of a Party (or its Affiliates) that are in excess of the budget (plus the Permitted Overage) for such costs
as set forth in the applicable Joint Development Plan and Budget, Global Commercialization Plan, Incremental Capacity Buildup Plan, Additional Research Plan or Commercial Capacity Buildup Plan, in each case, for the applicable Program, shall be
[***]. 
 9. Recording of Costs; Reports. Each Party shall keep records associated with Development Costs incurred through performance
of the Joint Development Plan and Budget for the applicable Program strictly separate from records associated with Development Costs incurred through performance of an Independent Additional Study Development Plan. Unless otherwise agreed by the
JSC, the financial data in the Shared Costs Report will include calculations in local currency and United States Dollars (converted into United States Dollars in accordance with Section 9.5(e) of the Agreement). The JSC shall approve the form
of any necessary documentation relating to any payments hereunder in connection with the Joint Development Program, Additional Study Development Plan, Global Commercialization Plan, Incremental Capacity Buildup Plan, or Commercial Capacity Buildup
Plan, as applicable, so as to afford the Parties appropriate accounting treatment in relation to any of the transactions or payments contemplated hereunder. 

10. Expense Reduction. The Parties agree to cooperate in identifying and implementing opportunities to reduce the costs incurred in the
conduct of each Joint Development Plan and Budget, Additional Study Development Plan, Global Commercialization Plan or Incremental Capacity Buildup Plan or Commercial Capacity Buildup Plan, as applicable, including costs of equipment, consumables
such as laboratory supplies and Third Party services such as toxicology, clinical studies or manufacturing services, provided such cooperation does not unduly delay or hamper a Party in the performance of its activities thereunder. 

11. Effective Accounting Date Termination. The Profit & Loss Share for a given Program shall continue until the earlier of the
last day of the month following the effective date of (a) the expiration of the Agreement with respect to such Program, or (b) the exercise of the Merck Cessation Election for such Program pursuant to Section 10.10 of the Agreement.
For clarity, following the discontinuation of the Profit & Loss Share for a given Program pursuant to subsection (b) above, the terms of Exhibit E shall apply. Termination of the Profit & Loss Share shall not relieve
either Party from its obligation to share Shared Collaboration Costs (including any Commercial Liabilities) relating to the period up to the date of termination or expiration. 
  

	12.	             [***] 

 

	 	            12.1	 [***] 

  

	13.	 [***] 

  

	            [***]	  

  

	14.	             [***] 

 

	 	            (a) [***]	 

  
 D-5 

 (b) [***]  

i. [***] 

ii. [***] 

iii. [***] 

iv. [***] 

(c) [***] 
  

	15.	 [***] 

  

																	
	 [***]
	  	[***]	 	 	[***]	 	 	[***]	 	 	[***]	 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 

  

	16.	 [***] 

16.1 [***] 

16.2 [***] 
 17.
Credit Against Profits Mechanism. The Credit Against Profits Mechanism with respect to the Profit & Loss Share shall operate as follows: 

17.1 [***] 

17.1.1 [***] 

17.1.2 [***] 

17.2 [***] 

17.2.1 [***] 

  
 D-6 

	 	17.2.2  	 [***] 

  

	 	17.3	 [***]  

 

	 	17.4	 [***] 

	18.	 [***]  

  

	 	18.1	 [***] 

  

	 	18.1.1	   [***] 

 

	 	18.1.2	   [***] 

 

	 	18.2	 [***] 

  

	 	18.2.1	   [***] 

 

	 	18.2.2	   [***] 

 

	19.	 [***] 

  

	20.	 [***]. 

  
 D-7 

 EXHIBIT E 

Economic Effects of Merck Non-Participation and 

Merck Cessation of Collaboration Activities 

This Exhibit E to the Agreement covers financial planning, accounting policies and procedures to be followed in
determining the economic effects and the cost sharing between the Parties in the following situations: (i) a Merck Non-Participation for a given Joint SAV Program or the PCV Program or (ii) a Merck Cessation Election for a given Joint SAV
Program or the PCV Program. For the avoidance of doubt, this Exhibit E shall apply and be calculated on a Program-by-Program basis.  

A. Merck Non-Participation for the PCV Program 

    The provisions of this Section A of Exhibit E (i.e., Paragraphs 1-13 of this Exhibit E) shall apply only to
Financial PCVs. 
 1. Allocation of Moderna Net Profits and Costs. 

1.1 In the event of a Merck Non-Participation for the PCV Program pursuant to Section 3.7(a) of the Agreement, subject to
[***]this Exhibit E, Merck shall be entitled to [***] (the “Non-Participation PCV Net Profit Share”). 

1.2 [***] 
 2.
Principles of Reporting. 
 2.1 The presentation of results of operations of Moderna with respect to Financial
PCVs will include each of the following line items (as each is defined in Exhibit B or elsewhere in the Agreement) be based on Moderna’s financial information presented separately and on a consolidated basis in the reporting format
depicted as follows: 
  

					
	 	  	[***]	 
	 [***]
	  			
	 [***]
	  			
	 [***]
	  			
	 [***]
	  			
	 [***]
	  			
	 [***]
	  			

 2.2 Effect of Commercial Grants. With respect to Financial PCVs, the following shall
apply: 
 2.2.1 In connection with a Commercial Grant: (a) such Third Party receiving the Commercial Grant [***], and
(b) [***] shall apply, unless [***]. 

  
 E-1 

 2.2.2 The treatment of a Commercial Grant under [***] pursuant to the
foregoing Paragraph 2.2.1 of this Exhibit E with respect to Commercial Grants by a Party or any of its Affiliates in [***] will require the prior written consent of the other Party, [***]t. 

2.2.3 Any Commercial Grant may include rights to Manufacture and Develop to support Commercialization in the country(ies) of
such Commercial Grant, but the Parties do not intend for Commercial Grants to be used to Develop or Manufacture the applicable Collaboration PCV Product(s) more generally. 

2.3 It is the intention of the Parties to interpret definitions to be consistent with this Exhibit E and GAAP
(except for Cost of Goods Sold given the exclusion of depreciation of certain assets in the calculation of Manufacturing Costs). Where costs included in the foregoing calculation are determined based on Moderna’s system of cost or project
accounting, Moderna agrees to provide reasonable supporting documentation, as may be requested by Merck, to ensure that Moderna’s methodologies are reasonable and consistently applied. To the extent that such costs are not readily determinable
based on Moderna’s system of cost or project accounting, the Parties will mutually develop a reasonable methodology for determining such costs. Reasonable methodologies may include a standard rate or some other appropriate basis for allocating
costs. For reconciliation, billing and reporting hereunder, any costs included in the above table incurred in a currency other than U.S. dollars will be translated into U.S. dollars in accordance with Section 9.5(e) of the Agreement.

 2.4 If necessary, Moderna will make the appropriate adjustments to the financial information it supplies under
this Exhibit E to conform to the above format of reporting results of operation. 
 3. Audits. The record keeping and
audit provisions set forth in Section 9.5(c) of the Agreement will apply with respect to all amounts payable by Moderna to Merck under this Exhibit E. 

4. Reporting of Moderna Costs. Within [***] days after the end of [***], Moderna shall provide Merck with a [***] summary statement
(with supporting documentation [***] of the Moderna Development Costs, Moderna Commercialization Costs and Costs of Goods Sold incurred by or on behalf of Moderna (or its Affiliate or Sublicensee) in such [***], as applicable for Financial PCVs
(each, a “Moderna Costs Report”). [***] 
 5. Reporting of Net Sales. On a [***] basis, Moderna will provide to Merck
an estimate of gross sales and Net Sales in U.S. dollars during the prior [***] of such Financial PCVs and units of such Financial PCV sold during such period according to Moderna’s sales reporting system, which will be consistent with the
financial planning, accounting and reporting procedures set forth in this Exhibit E. Each such report will be provided as early as possible, but no later than [***] days after the last day of the [***] in question, and will separately provide
[***] figures. The Parties understand that all Net Sales of Financial PCVs will be booked in accordance with GAAP and otherwise in accordance with the definition of Net Sales. 

  
 E-2 

 6. Recording of Costs; Reports. All Moderna Development Costs, Cost of Goods Sold and
Moderna Commercialization Costs pursuant to this Exhibit E shall be recorded and reported consistent with GAAP (except [***]), consistently applied. 

7. [***]. 

[***] 
 8.
[***] 
 (a) [***] 

(b) [***] 

(c) [***] 

(d) [***] 

(e) [***]  

(f) [***]  

9. [***] 
  

																	
	 	  	[***]	 	 	[***]	 	 	[***]	 	 	[***]	 
	 [***]
	  	 	[	***] 	 	 	[	***] 	 	 	[	***] 	 	 	[	***] 

 10. [***] 

10.1 [***] 

10.2 [***] 
 11.
Credit Against Profits Mechanism. The Credit Against Profits Mechanism with respect to the Non-Participation PCV Net Profit Share shall operate as follows: 

11.1 [***] 

11.2 [***] 

11.3 [***] 
 12.
[***]  
 12.1 [***] 

12.1.1 [***] 

12.1.2 [***] 

  
 E-3 

 13. [***] 

13.1 [***] 
 B.
Merck Cessation of Collaboration Activities for the PCV Program 
 The provisions of this Section B of Exhibit E
(i.e., Paragraphs 14-15 of this Exhibit E) shall apply only to Financial PCVs. 
 14. Allocation of Moderna Net Profits
and Costs. 
 14.1 In the event of a Merck Cessation Election for the PCV Program pursuant to Section 10.10 of the
Agreement, subject to the remainder of this Exhibit E[***], for each [***] following the effective date of the Merck Cessation Election for the PCV Program, Merck shall be entitled to [***] (the “PCV Cessation Net Profit
Share”). 
 14.2 [***]  

14.2.1 [***] 

14.2.2 [***] 

14.2.3 [***] 

14.3 [***]  

15. General. The provisions of Paragraphs 2 through 13 of this Exhibit E shall apply to the PCV Cessation Net Profit Share,
mutatis mutandis; [***]. 
 C. Merck Non-Participation for a Given Joint SAV
Program 
 The provisions of this Section C of Exhibit E (i.e., Paragraph 16 of this
Exhibit E) shall apply only to Financial SAVs and shall be calculated on a Joint SAV Program-by-Joint SAV Program basis. 
 16.
Allocation of Moderna Net Profits and Costs. 
 16.1 In the event of a Merck Non-Participation for a given Joint SAV
Program pursuant to Section 3.7(a) of the Agreement, subject to [***] this Exhibit E, Merck shall be entitled to [***] of Moderna Net Profits of Financial SAVs for a given [***] up to an aggregate amount equal to the Merck SAV Program
Costs for such Joint SAV Program (at which point, such SAVs for such Joint SAV Program shall cease to be Financial SAVs with no further action required by either Party)[***] (the “Non-Participation SAV Net Profit Share”). 

16.2 General. Paragraphs 2 through 13 of this Exhibit E shall apply to a given Joint SAV Program and the
Financial SAVs, mutatis mutandis. 

  
 E-4 

 D. Merck Cessation of Collaboration Activities for a Given SAV Program 

The provisions of this Section D of Exhibit E (i.e., Paragraph 17 of this Exhibit E)
shall apply only to Financial SAVs and shall be calculated on a Joint SAV Program-by-Joint SAV Program basis. 
 17. Allocation of
Moderna Net Profits and Costs 
 17.1 In the event of a Merck Cessation Election for a given Joint SAV Program pursuant
to Section 10.10 of the Agreement [***], then, for each [***] following the effective date of the Merck Cessation Election for such Joint SAV Program, Merck shall be entitled to [***] of Moderna Net Profits of Financial SAVs for a given [***]
up to an aggregate amount equal to the Merck SAV Program Costs (at which point, such SAVs for such Joint SAV Program shall cease to be Financial SAVs with no further action required by either Party); [***] (the “SAV Cessation [***] Capped
Net Profit Share”). 
 17.2 In the event of a Merck Cessation Election for a given Joint SAV Program pursuant to
Section 10.10 of the Agreement [***], Merck shall be entitled to [***] of Moderna Net Profits of Financial SAVs for a given [***] (each “SAV Cessation [***] Net Profit Share”). 

17.3 In the event of a Merck Cessation Election for a given Joint SAV Program pursuant to Section 10.10 of the Agreement
[***], then, for each [***] following the effective date of the Merck Cessation Election for such Joint SAV Program, Merck shall be entitled to [***] of Moderna Net Profits of Financial SAVs for a given [***] (each, a “SAV Cessation [***]
Net Profit Share”, and together with each SAV Cessation [***] Capped Net Profit Share and each SAV Cessation [***] Net Profit Share, the “SAV Cessation Net Profit Share”). 

17.4 SAV Cessation Net Profit Share Term. Payments to Merck related to the Moderna Net Profits of Financial SAVs under
Paragraphs 17.1, 17.2 or 17.3 of this Exhibit E will be payable following the effective date of the Merck Cessation Election, on the Moderna Net Profits of Financial SAVs and shall continue until the last day of the month following the
effective date of the expiration of the Agreement. 
 17.5 General. Paragraph 2-13, 14.2 of this Exhibit E
shall apply to a given Joint SAV Program and the Financial SAVs, mutatis mutandis; [***]. 
 E. Business
Combination.  
 [***] 

  
 E-5 

 EXHIBIT F 

In-Licenses 

1 Third Party In-Licenses. 

(a) Moderna Pre-Existing In-Licenses. Promptly following the Amended Effective Date, the Parties shall discuss in
good faith whether any Patents or Know-How in-licensed under a Moderna Pre-Existing In-License should be made available for use by the Parties, on a Program-by-Program basis, for the performance of Collaboration Activities under this Agreement,
including the Research, Development, Manufacture or Commercialization of a Collaboration Product with respect to such Program pursuant to the terms of this Agreement and, if the Parties mutually agree in writing, then, subject to and in accordance
with the terms of this Agreement and to the extent permitted under the applicable Moderna Pre-Existing In-License, the Patents and Know-How in-licensed under such Moderna Pre-Existing In-License shall be deemed to be Moderna Technology with respect
to such Program and such Moderna Pre-Existing In-License shall be deemed an “Included Moderna Pre-Existing In-License” with respect to such Program. 

(b) Moderna New In-Licenses. 

(i) Negotiation and Disclosure of Moderna New In-Licenses. After the Amended Effective Date, if Moderna identifies any
Patents or Know-How of a Third Party to which Moderna (and its Affiliates) does not have rights and that may be[***] for the performance of existing or future Collaboration Activities under this Agreement, including for the Research, Development,
Manufacture or Commercialization of mRNA Cancer Vaccines pursuant to the terms of this Agreement, Moderna may independently negotiate and enter into an agreement to obtain a license or other rights to such Patents or Know-How (each such agreement, a
“Moderna New In-License”); provided that (1) Moderna will [***] and (2) Moderna will use [***]. If Moderna (or its Affiliate) enters into such a Moderna New In-License, Moderna will disclose to Merck the terms of such
Moderna New In-License (including by providing a copy of such Moderna New In-License to Merck), subject to applicable confidentiality obligations and reasonable redaction of provisions that do not relate to the potential use of Patents and Know-How
in-licensed under such Moderna New In-License for the performance by the Parties of such existing or future Collaboration Activities, including the Research, Development, Manufacture or Commercialization of any mRNA Cancer Vaccines, and otherwise
provide Merck with [***] to assess whether or not any Patents or Know-How in-licensed under such Moderna New In-License should made available for use as set forth herein. 

(ii) Included Moderna New In-Licenses. Subject to Section 1(d) of this Exhibit F, if the Parties mutually
agree in writing that any Patents or Know-How in-licensed under a given Moderna New In-License should be made available for use by the Parties for the performance of any Collaboration Activities under this Agreement with respect to any Program,
including for the Research, Development, Manufacture or Commercialization of any Collaboration Product subject to and in accordance with the terms of this Agreement and to the extent permitted under such Moderna New In-License, then such Patents or
Know-How, as applicable, will be deemed Moderna Technology with respect to such Program (but subject to 

  
 F-1 

 
[***]) and such Moderna New In-License shall be deemed an “Included Moderna New In-License” with respect to such Program. If the Parties cannot agree whether any Patent or
Know-How licensed to Moderna or its Affiliate pursuant a Moderna New In-License should be made available for use by either Party for the performance of Collaboration Activities, or made available for the Research, Development, Manufacture or
Commercialization of any Collaboration Product, in each case, pursuant to the terms of this Agreement then (1) the Patents and Know-How in-licensed under such Moderna New In-License [***], (2) such Moderna New In-License [***],
(3) [***], (4) Merck will not [***], and (5) Merck will have no [***]. 
 (c) Merck In-Licenses.
In the event that, during the Collaboration Term for a given Program, Merck identifies any Patents or Know-How of a Third Party to which Merck (and its Affiliates) does not have rights and that may be [***] for the performance of Collaboration
Activities under this Agreement for such Program, including the Research, Development, Manufacture or Commercialization of any Collaboration Product as a part of such Program pursuant to this Agreement, Merck may independently negotiate and enter
into an agreement to obtain a license or other rights to such Patents or Know-How (each such agreement, a “Merck In-License”) provided that (1) Merck will [***] and (2) Merck will use [***]. In addition, if Merck (or its
Affiliates) has other Patents or Know-How that may be [***] for the performance of Collaboration Activities for a given Program under this Agreement, including the Research, Development, Manufacture or Commercialization of any Collaboration Product
pursuant to this Agreement and that Merck desires to bring into the Collaboration for such Program, but such Patents or Know-How are licensed to Merck (or its Affiliate) from a Third Party pursuant to an agreement between Merck (or its Affiliate)
and such Third Party (even if the agreement with the Third Party was entered into prior to the Effective Date), then, such agreement shall also be considered a “Merck In-License”. Solely to the extent Merck determines that the rights
in-licensed under a Merck In-License should be made available for use by the Parties for the performance of Collaboration Activities for a given Program under this Agreement, including for the Research, Development, Manufacture or Commercialization
of any Collaboration Product, then Merck will provide Moderna written notice thereof, which written notice shall include the terms of such Merck In-License, subject to applicable confidentiality obligations and reasonable redaction of provisions
that do not relate to the potential use of Patents and Know-How in-licensed under such Merck In-License for the performance by the Parties of such Collaboration Activities with respect to a Program, including the Research, Development, Manufacture
or Commercialization of any Collaboration Product as a part of such Program, and otherwise provide Moderna with [***] to assess whether or not any Patents or Know-How in-licensed under such Merck In-License should be made available for use as set
forth herein. Following Moderna’s receipt of such notice from Merck disclosing a given Merck In-License, the Parties shall discuss in good faith whether any Patents or Know-How in-licensed under such Merck In-License should be made available
for use by the Parties for the performance of Collaboration Activities with respect to a Program under this Agreement, including for the Research, Development, Manufacture or Commercialization of any Collaboration Product as a Party of such Program
and, if the Parties mutually agree in writing, then, in each case, pursuant to the terms of this Agreement and to the extent permitted under the applicable Merck In-License, then such Patents and Know-How, as applicable, shall be deemed to be Merck
Technology and such Merck In-License shall be deemed an “Included Merck In-License”. 

  
 F-2 

 (d) Permitted In-Licenses. Notwithstanding anything to the contrary
set forth herein, in the event that, during the POC Term for a given Program, to the extent Moderna reasonably determines that any Patents or Know-How in-licensed under a given Moderna New In-License [***] (such Moderna New In-License, a
“Permitted In-License”) should be made available for use by either Party for the performance of Collaboration Activities for such Program, including for the Research, Development, Manufacture or Commercialization of any
Collaboration Product as a part of such Program under this Agreement, subject to and in accordance with the terms of this Agreement and to the extent permitted under such Permitted In-License, then Moderna shall notify Merck in writing, which notice
shall include a copy of the applicable Permitted In-License (subject to confidentiality obligations and reasonable redaction) and specifically identify the applicable Patents or Know-How to be made available for use by the Parties for such use and,
upon Merck’s receipt of such notice, then such Patents or Know-How (as applicable) will be deemed Moderna Technology (subject to any limitations set forth in such Permitted In-License as disclosed by Moderna in such notice to Merck) with
respect to such Program and such Permitted In-License shall be deemed an “Included Permitted In-License” with respect to such Program, unless [***]. 

(e) Included In-License Requirements. 

(i) Scope. The sublicenses granted under any Included In-License (and further rights to sublicense) shall be [***].

 (ii) Sublicense Party. Each Party will abide, and will cause all its Affiliates and applicable Sublicensees to
abide, by all requirements of each Included In-License under which it is granted a sublicense hereunder (including with respect to the Research, Development, Manufacture or Commercialization of any Collaboration Products) in all material respects
[***], to the extent applicable to sublicensees thereunder and to the extent disclosed by the contracting Party to the other Party pursuant to Section 1(b), Section 1(c) or Section 1(d) of this Exhibit F, as applicable, prior
to the Parties’ determination as to whether such In-License should be an Included In-License, with the understanding that disclosure by a Party of any In-License to the other Party will be deemed disclosure of such requirements of such
In-License so disclosed to such other Party. 
 (iii) Maintenance of Included In-Licenses. The contracting Party to
any Included In-License (the “Contracting Party”) (A) will duly perform and observe all of its obligations under such Included In-Licenses in all material respects and maintain in full force and effect such Included In-License
and (B) will not, without the other Party’s prior written consent (such consent not to be unreasonably withheld, conditioned or delayed), [***] in each case ((A) and (B)) to the extent such action [***] would reasonably be expected to
materially adversely affect the Research, Development, Manufacture or Commercialization of any Collaboration Product hereunder or the rights of the other Party under this Agreement. The Contracting Party to any Included In-License will provide the
other Party with written notice as promptly as practicable after becoming aware of any of the following: [***]. If the Contracting Party fails to pay any amounts due under such Included In-License and if such nonpayment would permit the counterparty
to such Included In-License to terminate or suspend the same or any rights thereunder, then, to the extent permitted under the Included In-License, the other Party will have the right, but not the obligation, in its sole discretion, to pay such
amounts on the 

  
 F-3 

 
Contracting Party’s behalf, and any amounts so paid by the other Party may, to the extent that, as between the Parties, the Contracting Party is responsible for payment of such amounts in
accordance with Section 2 and Section 3 of this Exhibit F, be taken by such other Party as [***]. 
  

	 	(f)	 [***] 

 

	 	(g)	 [***] 

2 Upfront Payments for New In-Licenses. 

(a) [***] The Parties acknowledge that if the Contracting Party to a given New In-License has, prior to the date
that such New In-License becomes an Included In-License hereunder, paid to the licensor party thereto an upfront fee or other license fee to acquire rights to the applicable Included In-License IP (an “In-License Upfront Payment”),
then, prior to including such New In-License as an Included In-License hereunder, the Parties will agree on [***] of such In-License Upfront Payment [***]. 

(b) [***] In addition to [***] set forth in Section 2(a) of this Exhibit F, prior to including such
In-License as an Included In-License hereunder, the Parties will agree on [***]. 
 3 Included In-License Payments.
Except as set forth above in Section 2 of this Exhibit F: 
 (a) POC Program. With respect to a
given POC Program, if and to the extent that any Included In-License Payments become due during the POC Term for such POC Program, the Contracting Party will pay the same; provided that, (1) if Merck exercises the Merck Participation Election
for such POC Program, then the amount(s) of any [***], will, in each case [***], as of the Merck Participation Election Date for such Program at Merck’s election, be deemed [***], unless the non-Contracting Party elects to [***], and
(2) if Merck does not exercise the Merck Participation Election for such POC Program, then [***] Program will, in each case [***]. 

(b) Joint Development Programs – Allowable Development Costs. If and to the extent that any Included
In-License Payment becomes due with respect to activities under a Joint Development Program or an Additional Research Plan, the Contracting Party will pay the same, and such amount will be [***]. 

(c) Independent Additional Studies. If and to the extent that any Included In-License Payment becomes due with
respect to activities under an Independent Additional Study Development Plan, the Party sponsoring or conducting such Independent Additional Study will pay the same, and such amount will be [***]. 

(d) Commercialization. If and to the extent that any Included In-License Payment becomes due with respect to the
performance of Commercialization Activities in the Territory, the Contracting Party will pay the same and such payment will be treated as [***]. 

(e) Manufacturing. If and to the extent that any Included In-License Payment becomes due with respect to
Manufacturing activities undertaken pursuant to the activities described in clause (a), (b), (c) or (d) above, then the Parties’ respective responsibilities for such Included In-License Payment will be as set forth in such clause (a),
(b), (c) or (d), as applicable. 

  
 F-4 

 EXHIBIT G 

Confidential CMC Document Review Procedures 

1. In connection with any review conducted pursuant to Section 6.1(d), the Merck Representatives (as defined below) shall have the right
to review [***] (i) Confidential CMC Data or (ii) [***] (collectively, “Confidential CMC Documents”), solely for the purposes of assisting Merck in determining [***]. Merck’s participation in any such review of
Confidential CMC Documents is strictly limited to the Merck Representatives. In no event will Merck permit any Merck personnel other than the Merck Representatives to participate in any such review of any Confidential CMC Documents. For the purposes
of this Exhibit G, “Merck Representatives” shall mean Merck employees that [***]. 
 2. At Merck’s election,
Confidential CMC Documents [***] for review pursuant to this Exhibit G will be made available for review by the Merck Representatives either in [***]. 

3. [***] 
 4. Except as
otherwise set forth herein, in no event will (a) the Merck Representatives disclose or make available (directly or indirectly) any information learned from such review of, or otherwise pertaining to, the Confidential CMC Documents to anyone
other than providing to Merck’s (or its Affiliate’s) employees that [***], and (b) any Merck personnel who have received or who have access to (directly or indirectly) any such information pursuant to this Exhibit G use such
information for any purpose other than to [***]. Merck will ensure that any such individual having access to such information will be made aware of its highly confidential nature and will cause such individuals to comply with this Exhibit G.
 

  
 G-1 

 EXHIBIT H 

Moderna Technology Transfer 
 To
the extent there is a technology transfer, such technology transfer shall include the following: [***] 

  
 H-1 

 EXHIBIT I 

Form Press Release 

(See attached) 

  
 I-1 

 

 
 CONFIDENTIAL 
 Not For
Distribution 
 Moderna and Merck Expand mRNA Cancer Vaccines Collaboration 

Expansion Includes the Joint Development of Moderna’s KRAS Oncogene Program and Other 

Potential mRNA Cancer Vaccines; Merck Makes Equity Investment in Moderna 

CAMBRIDGE, Mass. and KENILWORTH N.J. April __, 2018 — Moderna Therapeutics and Merck (NYSE:MRK), known as MSD outside
the United States and Canada, today announced an expansion of their 2016 collaboration to develop and commercialize novel personalized messenger RNA (mRNA) cancer vaccines to now include shared antigen mRNA cancer vaccines including mRNA-5671,
Moderna’s mRNA KRAS cancer vaccine. 
 Moderna developed mRNA-5671 starting in 2017. The two companies will now advance jointly
mRNA-5671 in human studies and plan to conduct combination studies with additional immuno-oncology therapies. 
 “Augmentation of
immune responses offers great promise in cancer therapy, as our work with the PD-1-specific antibody KEYTRUDA has shown,” said Dr. Roger M. Perlmutter, President, Merck Research Laboratories. “We now look forward to expanding our
exploration of mRNA cancer vaccines, working in concert with our colleagues at Moderna.” 
 Under the expanded agreement, Merck will be
responsible for clinical development of mRNA-5671 and associated costs while Moderna will be responsible for clinical supply and associated costs. Following the completion of human proof-of-concept (hPOC) studies, Merck may opt-in on further
development and commercialization of mRNA-5671 upon payment of an undisclosed fee to Moderna. Following opt-in, the parties will share equally the global net profits and costs associated with mRNA-5671. As part of this agreement, the parties may
also initiate and collaborate on other shared antigen mRNA cancer vaccines programs. In addition, Merck made a $125 million investment in preferred equity in a newly priced series H round of financing. Moderna closed a $500 million series G round
earlier this year. 
 “We are excited to advance our novel mRNA KRAS cancer vaccine approach with Merck, which further extends our mRNA
platform in immuno-oncology,” said Stephane Bancel, Moderna’s Chief Executive Officer. “Along with our initial collaboration to take on the challenge of transforming the treatment of cancer by combining Merck’s KEYTRUDA with
Moderna’s mRNA-based personalized cancer vaccines, we believe there is a real opportunity to also pursue a shared cancer vaccine to specifically target patients with KRAS mutations.” 

  
 I-1 

 KRAS is one of the most frequently mutated oncogenes in human cancer, occurring in approximately
30 percent of certain cancer types. KRAS mutations are found principally in non-small cell lung cancer (NSCLC), colorectal cancer and pancreatic cancer, and are associated with worse outcomes. Hotspots of KRAS mutations are found in different tumor
types and can serve as tumor rejection epitopes. Presentation of these epitopes to the immune system may elicit an anti-tumor response. mRNA-5671 encodes for the four most commonly found KRAS mutations, and is designed to target most of the KRAS
mutations that occur in NSCLC, colorectal cancer and pancreatic cancer. 
 The Moderna KRAS mRNA program utilizes tumor sequencing to
identify suitable patients with specific mutations in KRAS in order to personalize their therapy, and complements the other personalized mRNA cancer vaccines in the collaboration. 

About the Updated Collaboration 
 The
alliance further builds on an initial strategic collaboration agreed to in June 2016 to jointly develop personalized mRNA cancer vaccines, combining Merck’s established leadership in immuno-oncology with Moderna’s pioneering mRNA
vaccine platform and GMP manufacturing capabilities, to advance individually tailored cancer vaccines for patients across a spectrum of cancers. Merck made an upfront cash payment to Moderna of $200 million, which Moderna is using to lead all
research and development efforts through proof of concept. 
 In November, 2017 the companies announced a key milestone with the
first-in-human dosing of mRNA-4157, an mRNA personalized cancer vaccine. The Phase 1 open-label, dose escalation, multicenter study in the United States (KEYNOTE-603) will assess the safety, tolerability and immunogenicity of mRNA-4157 alone in
subjects with resected solid tumors and in combination with KEYTRUDA® (pembrolizumab), an anti-PD-1 therapy, in subjects with unresectable solid tumors. 

About KEYTRUDA® (pembrolizumab) Injection 100mg 

KEYTRUDA is an anti-PD-1 therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells.
KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. 

Merck has the industry’s largest immuno-oncology clinical research program, which currently involves more than 700 trials studying
KEYTRUDA across a wide variety of cancers and treatment settings. The KEYTRUDA clinical program seeks to understand the role of KEYTRUDA across cancers and the factors that may predict a patient’s likelihood of benefitting from treatment with
KEYTRUDA, including exploring several different biomarkers. 
 KEYTRUDA® (pembrolizumab)
Indications and Dosing 
 Melanoma 

KEYTRUDA is indicated for the treatment of patients with unresectable or metastatic melanoma at a fixed dose of 200 mg every
three weeks until disease progression or unacceptable toxicity. 
 Lung Cancer 

KEYTRUDA, as a single agent, is indicated for the first-line treatment of patients with metastatic non-small cell lung cancer
(NSCLC) whose tumors have high PD-L1 expression [tumor proportion score (TPS) 350%] as determined by an FDA-approved test, with no EGFR or ALK genomic tumor aberrations. 

  
 I-2 

 KEYTRUDA, as a single agent, is also indicated for the treatment of patients with
metastatic NSCLC whose tumors express PD-L1 (TPS 31%) as determined by an FDA-approved test, with disease progression on or after platinum-containing chemotherapy. Patients with EGFR or ALK genomic tumor
aberrations should have disease progression on FDA-approved therapy for these aberrations prior to receiving KEYTRUDA. 

KEYTRUDA, in combination with pemetrexed and carboplatin, is indicated for the first-line treatment of patients with
metastatic nonsquamous NSCLC. This indication is approved under accelerated approval based on tumor response rate and progression-free survival. Continued approval for this indication may be contingent upon verification and description of clinical
benefit in the confirmatory trials. 
 In metastatic NSCLC, KEYTRUDA is administered at a fixed dose of 200 mg every three
weeks until disease progression, unacceptable toxicity, or up to 24 months in patients without disease progression. 
 When
administering KEYTRUDA in combination with chemotherapy, KEYTRUDA should be administered prior to chemotherapy when given on the same day. See also the Prescribing Information for pemetrexed and carboplatin. 

Head and Neck Cancer 

KEYTRUDA is indicated for the treatment of patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)
with disease progression on or after platinum-containing chemotherapy. This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for this indication may be contingent upon
verification and description of clinical benefit in the confirmatory trials. In HNSCC, KEYTRUDA is administered at a fixed dose of 200 mg every three weeks until disease progression, unacceptable toxicity, or up to 24 months in patients without
disease progression. 
 Classical Hodgkin Lymphoma 

KEYTRUDA is indicated for the treatment of adult and pediatric patients with refractory classical Hodgkin lymphoma (cHL), or
who have relapsed after three or more prior lines of therapy. This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for this indication may be contingent upon verification
and description of clinical benefit in the confirmatory trials. In adults with cHL, KEYTRUDA is administered at a fixed dose of 200 mg every three weeks until disease progression or unacceptable toxicity, or up to 24 months in patients without
disease progression. In pediatric patients with cHL, KEYTRUDA is administered at a dose of 2 mg/kg (up to a maximum of 200 mg) every three weeks until disease progression or unacceptable toxicity, or up to 24 months in patients without disease
progression. 
 Urothelial Carcinoma 

KEYTRUDA is indicated for the treatment of patients with locally advanced or metastatic urothelial carcinoma who are not
eligible for cisplatin-containing chemotherapy. This indication is approved under accelerated approval based on tumor response rate and duration of response. Continued approval for this indication may be contingent upon verification and description
of clinical benefit in the confirmatory trials. 
 KEYTRUDA is also indicated for the treatment of patients with locally
advanced or metastatic urothelial carcinoma who have disease progression during or following platinum-containing chemotherapy or within 12 months of neoadjuvant or adjuvant treatment with platinum-containing chemotherapy. 

  
 I-3 

 In locally advanced or metastatic urothelial carcinoma, KEYTRUDA is administered
at a fixed dose of 200 mg every three weeks until disease progression or unacceptable toxicity, or up to 24 months in patients without disease progression. 

Microsatellite Instability-High (MSI-H) Cancer 

KEYTRUDA is indicated for the treatment of adult and pediatric patients with unresectable or metastatic microsatellite
instability-high (MSI-H) or mismatch repair deficient (dMMR) 
  

	 	•	 	 solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment
options, or 

  

	 	•	 	 colorectal cancer that has progressed following treatment with fluoropyrimidine, oxaliplatin, and irinotecan.

 This indication is approved under accelerated approval based on tumor response rate and durability of
response. Continued approval for this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials. The safety and effectiveness of KEYTRUDA in pediatric patients with MSI-H central nervous system
cancers have not been established. 
 In adult patients with MSI-H cancer, KEYTRUDA is administered at a fixed dose of 200
mg every three weeks until disease progression, unacceptable toxicity, or up to 24 months in patients without disease progression. In children with MSI-H cancer, KEYTRUDA is administered at a dose of 2 mg/kg (up to a maximum of 200 mg) every three
weeks until disease progression or unacceptable toxicity, or up to 24 months in patients without disease progression. 
 Gastric Cancer 

KEYTRUDA is indicated for the treatment of patients with recurrent locally advanced or metastatic gastric or gastroesophageal
junction (GEJ) adenocarcinoma whose tumors express PD-L1 [Combined Positive Score (CPS) 31] as determined by an FDA-approved test, with disease progression on or after two or more prior lines of therapy
including fluoropyrimidine- and platinum-containing chemotherapy and if appropriate, HER2/neu-targeted therapy. This indication is approved under accelerated approval based on tumor response rate and durability of response. Continued approval for
this indication may be contingent upon verification and description of clinical benefit in the confirmatory trials. The recommended dose of KEYTRUDA is 200 mg every three weeks until disease progression, unacceptable toxicity, or up to 24 months in
patients without disease progression. 
 Selected Important Safety Information for KEYTRUDA®  
 KEYTRUDA can cause immune-mediated pneumonitis, including fatal
cases. Pneumonitis occurred in 94 (3.4%) of 2799 patients receiving KEYTRUDA, including Grade 1 (0.8%), 2 (1.3%), 3 (0.9%), 4 (0.3%), and 5 (0.1%) pneumonitis, and occurred more frequently in patients with a history of prior thoracic radiation
(6.9%) compared to those without (2.9%). Monitor patients for signs and symptoms of pneumonitis. Evaluate suspected pneumonitis with radiographic imaging. Administer corticosteroids for Grade 2 or greater pneumonitis. Withhold KEYTRUDA for
Grade 2; permanently discontinue KEYTRUDA for Grade 3 or 4 or recurrent Grade 2 pneumonitis. 
 KEYTRUDA can cause
immune-mediated colitis. Colitis occurred in 48 (1.7%) of 2799 patients receiving KEYTRUDA, including Grade 2 (0.4%), 3 (1.1%), and 4 (<0.1%) colitis. Monitor patients for signs and symptoms of colitis. Administer corticosteroids for Grade 2
or greater colitis. Withhold KEYTRUDA for Grade 2 or 3; permanently discontinue KEYTRUDA for Grade 4 colitis. 
 KEYTRUDA
can cause immune-mediated hepatitis. Hepatitis occurred in 19 (0.7%) of 2799 patients receiving KEYTRUDA, including Grade 2 (0.1%), 3 (0.4%), and 4 (<0.1%) hepatitis. Monitor patients for changes in liver function. Administer corticosteroids for
Grade 2 or greater hepatitis and, based on severity of liver enzyme elevations, withhold or discontinue KEYTRUDA. 

  
 I-4 

 KEYTRUDA can cause hypophysitis. Hypophysitis occurred in 17 (0.6%) of 2799
patients receiving KEYTRUDA, including Grade 2 (0.2%), 3 (0.3%), and 4 (<0.1%) hypophysitis. Monitor patients for signs and symptoms of hypophysitis (including hypopituitarism and adrenal insufficiency). Administer corticosteroids and hormone
replacement as clinically indicated. Withhold KEYTRUDA for Grade 2; withhold or discontinue for Grade 3 or 4 hypophysitis. 

KEYTRUDA can cause thyroid disorders, including hyperthyroidism, hypothyroidism, and thyroiditis. Hyperthyroidism occurred in
96 (3.4%) of 2799 patients receiving KEYTRUDA, including Grade 2 (0.8%) and 3 (0.1%) hyperthyroidism. Hypothyroidism occurred in 237 (8.5%) of 2799 patients receiving KEYTRUDA, including Grade 2 (6.2%) and 3 (0.1%) hypothyroidism. The
incidence of new or worsening hypothyroidism was higher in patients with HNSCC, occurring in 28 (15%) of 192 patients with HNSCC, including Grade 3 (0.5%) hypothyroidism. Thyroiditis occurred in 16 (0.6%) of 2799 patients receiving KEYTRUDA,
including Grade 2 (0.3%) thyroiditis. Monitor patients for changes in thyroid function (at the start of treatment, periodically during treatment, and as indicated based on clinical evaluation) and for clinical signs and symptoms of thyroid
disorders. Administer replacement hormones for hypothyroidism and manage hyperthyroidism with thionamides and beta-blockers as appropriate. Withhold or discontinue KEYTRUDA for Grade 3 or 4 hyperthyroidism. 

KEYTRUDA can cause type 1 diabetes mellitus, including diabetic ketoacidosis, which have been reported in 6 (0.2%) of 2799
patients. Monitor patients for hyperglycemia or other signs and symptoms of diabetes. Administer insulin for type 1 diabetes, and withhold KEYTRUDA and administer antihyperglycemics in patients with severe hyperglycemia. 

KEYTRUDA can cause immune-mediated nephritis. Nephritis occurred in 9 (0.3%) of 2799 patients receiving KEYTRUDA, including
Grade 2 (0.1%), 3 (0.1%), and 4 (<0.1%) nephritis. Monitor patients for changes in renal function. Administer corticosteroids for Grade 2 or greater nephritis. Withhold KEYTRUDA for Grade 2; permanently discontinue KEYTRUDA for Grade 3 or 4
nephritis. 
 Immune-mediated rashes, including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) (some cases
with fatal outcome), exfoliative dermatitis, and bullous pemphigoid, can occur. Monitor patients for suspected severe skin reactions and based on the severity of the adverse reaction, withhold or permanently discontinue KEYTRUDA and administer
corticosteroids. For signs or symptoms of SJS or TEN, withhold KEYTRUDA and refer the patient for specialized care for assessment and treatment. If SJS or TEN is confirmed, permanently discontinue KEYTRUDA. 

KEYTRUDA can cause other clinically important immune-mediated adverse reactions. These immune-mediated reactions may occur in
any organ system. For suspected immune-mediated adverse reactions, ensure adequate evaluation to confirm etiology or exclude other causes. Based on the severity of the adverse reaction, withhold KEYTRUDA and administer corticosteroids. Upon
improvement to Grade 1 or less, initiate corticosteroid taper and continue to taper over at least 1 month. Based on limited data from clinical studies in patients whose immune-related adverse reactions could not be controlled with corticosteroid
use, administration of other systemic immunosuppressants can be considered. Resume KEYTRUDA when the adverse reaction remains at Grade 1 or less following corticosteroid taper. Permanently discontinue KEYTRUDA for any Grade 3 immune-mediated adverse
reaction that recurs and for any life-threatening immune-mediated adverse reaction. 
 The following clinically significant
immune-mediated adverse reactions occurred in less than 1% (unless otherwise indicated) of 2799 patients: arthritis (1.5%), uveitis, myositis, Guillain-Barré syndrome, myasthenia gravis, vasculitis, pancreatitis, hemolytic anemia, and partial
seizures arising in a patient with inflammatory foci in brain parenchyma. In addition, myelitis and myocarditis were reported in other clinical trials, including classical Hodgkin lymphoma, and postmarketing use. 

  
 I-5 

 Solid organ transplant rejection has been reported in postmarketing use of
KEYTRUDA. Treatment with KEYTRUDA may increase the risk of rejection in solid organ transplant recipients. Consider the benefit of treatment with KEYTRUDA vs the risk of possible organ rejection in these patients. 

KEYTRUDA can cause severe or life-threatening infusion-related reactions, including hypersensitivity and anaphylaxis, which
have been reported in 6 (0.2%) of 2799 patients. Monitor patients for signs and symptoms of infusion-related reactions, including rigors, chills, wheezing, pruritus, flushing, rash, hypotension, hypoxemia, and fever. For Grade 3 or 4 reactions, stop
infusion and permanently discontinue KEYTRUDA. 
 Immune-mediated complications, including fatal events, occurred in
patients who underwent allogeneic hematopoietic stem cell transplantation (HSCT) after being treated with KEYTRUDA. Of 23 patients with cHL who proceeded to allogeneic HSCT after treatment with KEYTRUDA on any trial, 6 patients (26%) developed
graft-versus-host disease (GVHD), one of which was fatal, and 2 patients (9%) developed severe hepatic veno-occlusive disease (VOD) after reduced-intensity conditioning, one of which was fatal. Cases of fatal hyperacute GVHD after allogeneic
HSCT have also been reported in patients with lymphoma who received a PD-1 receptor–blocking antibody before transplantation. 

These complications may occur despite intervening therapy between PD-1 blockade and allogeneic HSCT. Follow patients closely
for early evidence of transplant-related complications such as hyperacute GVHD, severe (Grade 3 to 4) acute GVHD, steroid-requiring febrile syndrome, hepatic VOD, and other immune-mediated adverse reactions, and intervene promptly. 

In clinical trials in patients with multiple myeloma, the addition of KEYTRUDA to a thalidomide analogue plus dexamethasone
resulted in increased mortality. Treatment of these patients with a PD-1 or PD-L1 blocking antibody in this combination is not recommended outside of controlled clinical trials. 

Based on its mechanism of action, KEYTRUDA can cause fetal harm when administered to a pregnant woman. If used during
pregnancy, or if the patient becomes pregnant during treatment, apprise the patient of the potential hazard to a fetus. Advise females of reproductive potential to use highly effective contraception during treatment and for 4 months after the last
dose of KEYTRUDA. 
 In KEYNOTE-006, KEYTRUDA was discontinued due to adverse reactions in 9% of 555 patients with advanced
melanoma; adverse reactions leading to discontinuation in more than one patient were colitis (1.4%), autoimmune hepatitis (0.7%), allergic reaction (0.4%), polyneuropathy (0.4%), and cardiac failure (0.4%). Adverse reactions leading to interruption
of KEYTRUDA occurred in 21% of patients; the most common (31%) was diarrhea (2.5%). The most common adverse reactions with KEYTRUDA vs ipilimumab were fatigue (28% vs 28%), diarrhea (26% with KEYTRUDA),
rash (24% vs 23%), and nausea (21% with KEYTRUDA). Corresponding incidence rates are listed for ipilimumab only for those adverse reactions that occurred at the same or lower rate than with KEYTRUDA. 

In KEYNOTE-010, KEYTRUDA monotherapy was discontinued due to adverse reactions in 8% of 682 patients with metastatic NSCLC.
The most common adverse event resulting in permanent discontinuation of KEYTRUDA was pneumonitis (1.8%). Adverse reactions leading to interruption of KEYTRUDA occurred in 23% of patients; the most common
(31%) were diarrhea (1%), fatigue (1.3%), pneumonia (1%), liver enzyme elevation (1.2%), decreased appetite (1.3%), and pneumonitis (1%). The most common adverse reactions (occurring in at least 20% of
patients and at a higher incidence than with docetaxel) were decreased appetite (25% vs 23%), dyspnea (23% vs 20%), and nausea (20% vs 18%). 

In KEYNOTE-021(G1), when KEYTRUDA was administered in combination with carboplatin and pemetrexed (carbo/pem) in advanced
nonsquamous NSCLC, KEYTRUDA was discontinued in 10% of 59 patients. The most common adverse reaction resulting in discontinuation of KEYTRUDA (32%) was acute kidney injury (3.4%). Adverse reactions
leading to interruption of KEYTRUDA occurred in 39% of 

  
 I-6 

 
patients; the most common (32%) were fatigue (8%), neutrophil count decreased (8%), anemia (5%), dyspnea (3.4%), and pneumonitis (3.4%). The most
common adverse reactions (320%) with KEYTRUDA compared to carbo/pem alone were fatigue (71% vs 50%), nausea (68% vs 56%), constipation (51% vs 37%), rash (42% vs 21%), vomiting (39% vs 27%), dyspnea (39%
vs 21%), diarrhea (37% vs 23%), decreased appetite (31% vs 23%), headache (31% vs 16%), cough (24% vs 18%), dizziness (24% vs 16%), insomnia (24% vs 15%), pruritus (24% vs 4.8%), peripheral edema (22% vs 18%), dysgeusia (20% vs 11%), alopecia (20%
vs 3.2%), upper respiratory tract infection (20% vs 3.2%), and arthralgia (15% vs 24%). This study was not designed to demonstrate a statistically significant difference in adverse reaction rates for KEYTRUDA as compared to carbo/pem alone for any
specified adverse reaction. 
 In KEYNOTE-012, KEYTRUDA was discontinued due to adverse reactions in 17% of 192 patients
with HNSCC. Serious adverse reactions occurred in 45% of patients. The most frequent serious adverse reactions reported in at least 2% of patients were pneumonia, dyspnea, confusional state, vomiting, pleural effusion, and respiratory failure. The
most common adverse reactions (reported in at least 20% of patients) were fatigue, decreased appetite, and dyspnea. Adverse reactions occurring in patients with HNSCC were generally similar to those occurring in patients with melanoma or NSCLC, with
the exception of increased incidences of facial edema (10% all Grades; 2.1% Grades 3 or 4) and new or worsening hypothyroidism. 

In KEYNOTE-087, KEYTRUDA was discontinued due to adverse reactions in 5% of 210 patients with cHL, and treatment was
interrupted due to adverse reactions in 26% of patients. Fifteen percent (15%) of patients had an adverse reaction requiring systemic corticosteroid therapy. Serious adverse reactions occurred in 16% of patients. The most frequent serious
adverse reactions (31%) included pneumonia, pneumonitis, pyrexia, dyspnea, GVHD, and herpes zoster. Two patients died from causes other than disease progression; one from GVHD after subsequent
allogeneic HSCT and one from septic shock. The most common adverse reactions (occurring in 320% of patients) were fatigue (26%), pyrexia (24%), cough (24%), musculoskeletal pain (21%), diarrhea (20%), and
rash (20%). 
 In KEYNOTE-052, KEYTRUDA was discontinued due to adverse reactions in 11% of 370 patients with locally
advanced or metastatic urothelial carcinoma. The most common adverse reactions (in 320% of patients) were fatigue (38%), musculoskeletal pain (24%), decreased appetite (22%), constipation (21%), rash
(21%), and diarrhea (20%). Eighteen patients (5%) died from causes other than disease progression. Five patients (1.4%) who were treated with KEYTRUDA experienced sepsis which led to death, and 3 patients (0.8%) experienced pneumonia which
led to death. Adverse reactions leading to interruption of KEYTRUDA occurred in 22% of patients; the most common (31%) were liver enzyme increase, diarrhea, urinary tract infection, acute kidney injury,
fatigue, joint pain, and pneumonia. Serious adverse reactions occurred in 42% of patients, the most frequent (32%) of which were urinary tract infection, hematuria, acute kidney injury, pneumonia, and
urosepsis. 
 In KEYNOTE-045, KEYTRUDA was discontinued due to adverse reactions in 8% of 266 patients with locally advanced
or metastatic urothelial carcinoma. The most common adverse reaction resulting in permanent discontinuation of KEYTRUDA was pneumonitis (1.9%). Adverse reactions leading to interruption of KEYTRUDA occurred in 20% of patients; the most common (31%) were urinary tract infection (1.5%), diarrhea (1.5%), and colitis (1.1%). The most common adverse reactions (320%) in patients who received KEYTRUDA vs
those who received chemotherapy were fatigue (38% vs 56%), musculoskeletal pain (32% vs 27%), pruritus (23% vs 6%), decreased appetite (21% vs 21%), nausea (21% vs 29%), and rash (20% vs 13%). Serious adverse reactions occurred in 39% of
KEYTRUDA-treated patients, the most frequent (32%) of which were urinary tract infection, pneumonia, anemia, and pneumonitis. 

  
 I-7 

 It is not known whether KEYTRUDA is excreted in human milk. Because many drugs
are excreted in human milk, instruct women to discontinue nursing during treatment with KEYTRUDA and for 4 months after the final dose. 

There is limited experience in pediatric patients. In a study, 40 pediatric patients (16 children aged 2 years to younger than 12 years and 24
adolescents aged 12 years to 18 years) with advanced melanoma, lymphoma, or PD-L1–positive advanced, relapsed, or refractory solid tumors were administered KEYTRUDA 2 mg/kg every 3 weeks. Patients received KEYTRUDA for a median of 3 doses
(range 1–17 doses), with 34 patients (85%) receiving KEYTRUDA for 2 doses or more. The safety profile in these pediatric patients was similar to that seen in adults treated with KEYTRUDA. Toxicities that occurred at a higher rate (315% difference) in these patients when compared to adults under 65 years of age were fatigue (45%), vomiting (38%), abdominal pain (28%), hypertransaminasemia (28%), and hyponatremia (18%). 

About Merck 
 For more than a century,
Merck, a leading global biopharmaceutical company known as MSD outside of the United States and Canada, has been inventing for life, bringing forward medicines and vaccines for many of the world’s most challenging diseases. Through our
prescription medicines, vaccines, biologic therapies and animal health products, we work with customers and operate in more than 140 countries to deliver innovative health solutions. We also demonstrate our commitment to increasing access to health
care through far-reaching policies, programs and partnerships. Today, Merck continues to be at the forefront of research to advance the prevention and treatment of diseases that threaten people and communities around the world—including cancer,
cardio-metabolic diseases, emerging animal diseases, Alzheimer’s disease and infectious diseases including HIV and Ebola. For more information, visit www.merck.com and connect with us
on Twitter, Facebook, Instagram, YouTube and LinkedIn. 
 About Moderna
Therapeutics Moderna pioneers the discovery and development of messenger RNA (mRNA) therapeutics and vaccines, an entirely new class of medicines that directs the body’s cells to produce intracellular or secreted proteins that can have a
therapeutic or preventive benefit for both patients and healthy individuals. With its breakthrough platform, Moderna is creating mRNA medicines for a wide range of diseases and conditions, in many cases by addressing currently undruggable targets or
underserved areas of medical need. Moderna is developing its innovative mRNA medicines for infectious diseases, immuno-oncology, rare diseases, and cardiovascular diseases, through solely controlled programs and collaborations with strategic
partners. 
 Headquartered in Cambridge, Mass., privately held Moderna currently has strategic relationships with AstraZeneca, Plc. (AZ),
Merck (MRK) and Vertex Pharmaceuticals (VRTX), as well as the Defense Advanced Research Projects Agency (DARPA), an agency of the U.S. Department of Defense; the Biomedical Advanced Research and Development Authority (BARDA), a division of the
Office of the Assistant Secretary for Preparedness and Response (ASPR) within the U.S. Department of Health and Human Services (HHS); and the Bill & Melinda Gates Foundation. In 2017 Moderna was ranked a top biopharma industry employer
by Science Magazine and a Top Places to Work by the Boston Globe. To learn more, visit www.modernatx.com. 

  
 I-8 

 Forward-looking Statement of Merck & Co., Inc., Kenilworth, N.J., USA 

This news release of Merck & Co., Inc., Kenilworth, N.J., USA (the “company”) includes “forward-looking statements” within the
meaning of the safe harbor provisions of the U.S. Private Securities Litigation Reform Act of 1995. These statements are based upon the current beliefs and expectations of the company’s management and are subject to significant risks and
uncertainties. There can be no guarantees with respect to pipeline products that the products will receive the necessary regulatory approvals or that they will prove to be commercially successful. If underlying assumptions prove inaccurate or risks
or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. 
 Risks and
uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and health care
legislation in the United States and internationally; global trends toward health care cost containment; technological advances, new products and patents attained by competitors; challenges inherent in new product development, including obtaining
regulatory approval; the company’s ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of the
company’s patents and other protections for innovative products; and the exposure to litigation, including patent litigation, and/or regulatory actions. 

The company undertakes no obligation to publicly update any forward-looking statement, whether as a result of new information, future events
or otherwise. Additional factors that could cause results to differ materially from those described in the forward-looking statements can be found in the company’s 2017 Annual Report on Form 10-K and the company’s other filings with the
Securities and Exchange Commission (SEC) available at the SEC’s Internet site (www.sec.gov). 

  
 I-9 

 EXHIBIT J 

Patent Prosecution and Maintenance; Patent Enforcement 

1. Patent Committee. 

1.1 Composition. The IP Committee shall comprise [***] representatives of Merck and [***] representatives of Moderna.
Each Party may change its representatives to the IP Committee from time to time in its sole discretion, effective upon notice to the other Party of such change. These representatives shall have appropriate expertise, seniority, decision-making
authority and ongoing familiarity with the Collaboration, and each Party’s representatives collectively will have relevant expertise in intellectual property portfolio management and licensing matters. With the consent of the other Party (such
consent not to be unreasonably withheld, delayed or conditioned), each Party may invite employees and consultants to attend meetings of the IP Committee, subject to their agreement to be bound to the same extent as a permitted subcontractor under
Section 10.4. The IP Committee may change its size from time to time by mutual consent of its members; provided that the IP Committee will consist at all times of an equal number of representatives of each of Merck and Moderna. 

1.2 Meetings. The IP Committee will meet as necessary to carry out its duties under Paragraph 1.1, but at least [***] per
Calendar Quarter during the Collaboration Term, unless otherwise agreed by its members. The IP Committee will meet in-person at Moderna or Merck or, alternatively, by means of teleconference, videoconference or other similar communications
equipment. 
 1.3 IP Committee Responsibilities. The IP Committee will provide input regarding the strategy of
Prosecuting and Maintaining [***] with respect to a given Program, including the following activities:  
 1.3.1
[***] 
 1.3.2 [***] 

1.3.3 [***] 

1.3.4 [***] 

1.3.5 [***] 

1.3.6 [***] 

1.3.7 [***] 

1.3.8 [***] 

1.3.9 [***] 

1.3.10 [***] 

  
 J-1 

 1.3.11 [***] 

1.4 Decision-Making Authority. The IP Committee will be an advisory committee for the Collaboration and to the
Parties and will make recommendations by consensus. The IP Committee will not have any final decision-making power, and its discussions with not be subject to review or approval by the JSC. 

2. Prosecution and Maintenance. 

2.1 Moderna Patents. 

2.1.1 Moderna General Patents and Moderna Agent Technology. Moderna shall have the sole right, but not the
obligation, at its own expense and through counsel of its own choosing, to Prosecute and Maintain the Moderna General Patents and any Patents within the Moderna Agent Technology worldwide. 

2.1.2 [***] 

2.1.3 [***] 

2.1.4 [***] 

2.2 Merck Patents. 

2.2.1 Merck General Patents and Merck Agent Technology. Merck shall have the sole right, but not the obligation,
at its own expense and using counsel of its own choosing, to Prosecute and Maintain the Merck General Patents and any Patents within the Merck Agent Technology worldwide. 

2.2.2 [***]  

2.3 Patent Costs. Patent and Trademark Expenses incurred by the prosecuting Party in connection with Prosecuting and
Maintaining [***], as applicable (but not any [***]), shall be treated in accordance with this Exhibit J or Exhibit D or Exhibit E, as follows: 

2.3.1 for such Patent and Trademark Expenses accrued by the Parties during the applicable POC Term, if (a) Merck
exercises the Merck Participation Election for a given Program, then [***], and (b) if Merck does not exercise the Merck Participation Election for the PCV Program, then [***]; 

2.3.2 such Patent and Trademark Expenses incurred by or on behalf of each Party (or its Affiliates) during the Merck
Participation Term for a given Program will be treated as [***]; 
 2.3.3 such Patent and Trademark Expenses incurred by or
on behalf of each Party (or its Affiliates) in the event of a Merck Non-Participation for the PCV Program or a Merck Cessation Election for the PCV Program will be treated as [***] 

  
 J-2 

 2.3.4 such Patent and Trademark Expenses incurred by or on behalf of a Party (or
its Affiliates) in the event of a Merck Non-Participation for a given SAV Program or a Merck Cessation Election for a given SAV Program will be [***]. 

2.4 Cooperation. The Parties agree to cooperate fully in the Prosecution and Maintenance of the Moderna Patents and
Merck Patents in the Territory under this Agreement. Cooperation shall include: 
 2.4.1 executing all papers and
instruments, or requiring its employees or contractors to execute such papers and instruments, so as to (a) effectuate the ownership of intellectual property set forth in Section 11; (b) enable the other Party to apply for and to
prosecute Patent applications in the Territory; and (c) obtain and maintain any Patent extensions, supplementary protection certificates, and the like with respect to the Moderna Patents and Merck Patents in the Territory, in each case, to the
extent provided for in this Agreement; 
 2.4.2 consistent with this Agreement, assisting in any license registration
processes with applicable governmental authorities that may be available in the Territory for the protection of a Party’s interests in this Agreement; and 

2.4.3 promptly informing the other Party of any matters coming to such Party’s attention that may materially affect the
Prosecution and Maintenance of any such Moderna Patents or Merck Patents in the Territory. 
 3. Patent Extensions. With respect to
any election for patent term restoration or extension, supplemental protection certificate or any of their equivalents, (a) Merck will have the sole right to make any such decision relating to the Merck Patents; provided that [***];
(b) Moderna will have the right to make any such decision relating to the Moderna Patents; provided that, [***] and (c) if either Party requests that the other Party make any election for patent term restoration or extension, supplemental
protection certificate or any of their equivalents with respect to which such other Party has sole decision making authority pursuant to this Paragraph 2, the Parties shall discuss and such other Party shall consider in good faith any such request.

 4. Patent Listings. With respect to any filings made to Regulatory Authorities with respect to the Moderna Patents or Merck Patents
for any Collaboration Product, including as required or allowed in connection with in the United States, the FDA’s Orange Book, if applicable, or outside the United States, other international equivalents, [***] will have the sole right to make
any such decision. Upon the request by [***], [***] will reasonably cooperate in the implementation of decisions regarding the filing and listing pursuant to this Paragraph 3. 

5. Patent Enforcement and Defense. 

5.1 Notice. With respect to a given Program, each Party will promptly notify the other Party, in writing, upon learning
of any [***] (in each case [***], a “Competitive Infringement”), or of [***], would amount to Competitive Infringement, and will, along with such notice, provide any evidence in its possession pertaining thereto, subject to Third
Party confidentiality obligations. 

  
 J-3 

 5.2 Competitive Infringement. 

5.2.1 [***]  

5.2.2 General Patents. [***]  

5.2.3 [***]  

5.2.4 Neither Party will exercise any of its enforcement rights under Paragraph 5.2.1 without first consulting with the other
Party, provided that this consultation requirement will not limit either Party’s rights under this Paragraph 5.2. 
 5.3
Defense. 
 5.3.1 [***] 

5.3.2 [***] 

5.3.3 [***] 

5.4 Withdrawal, Cooperation and Participation. With respect to any infringement or defensive action identified above in
Paragraphs 5.2 or 5.3: 
 5.4.1 If the controlling Party ceases to pursue or withdraws from such action, it will promptly
notify the other Party (in sufficient time to enable the other Party to meet any deadlines by which any action must be taken to preserve any rights in such infringement or defensive action) and such other Party may substitute itself for the
withdrawing Party and proceed under the terms and conditions of [***]. 
 5.4.2 The non-controlling Party will cooperate
with the Party controlling any such action (as may be reasonably requested by the controlling Party), including [***]. The Party controlling any such action will keep the non-controlling Party updated with respect to any such action, including
providing copies of all documents received or filed in connection with any such action. 
 5.4.3 Each Party will have the
right to participate or otherwise be involved in any such action controlled by the other Party, in each case at the non-controlling Party’s sole cost and expense. If a Party elects to so participate or be involved, the controlling Party will
provide the non-controlling Party and its counsel with an opportunity to consult with the controlling Party and its counsel regarding the prosecution of such action (including reviewing the contents of any correspondence, legal papers or other
documents related thereto), and the controlling Party will take into account reasonable requests of the non-controlling Party regarding such enforcement or defense. 

5.4.4 In all cases, prior to the commencement of any infringement or defensive action identified above in Paragraphs 5.2 or
5.3, the Parties shall reasonably consult with respect thereto, including a discussion of the relevant Patents to be included in any such action. 

  
 J-4 

 5.5 Damages. Unless otherwise agreed by the Parties, [***], all monies
recovered upon the final judgment or settlement of any such action will be [***]. Unless otherwise agreed by the Parties, [***], all monies recovered upon the final judgment or settlement of any such action shall be treated [***]. 

5.6 Agent Technology. Notwithstanding anything in this Agreement to the contrary, Moderna has the sole right to enforce
and defend all Patents within the Moderna Agent Technology, and Merck has the sole right to enforce and defend all Patents within the Merck Agent Technology. 

5.7 [***] 

6. Third Party Rights. Notwithstanding the foregoing provisions of this Exhibit J, each Party’s rights and obligations under
this Exhibit J will be subject to the Third Party rights and obligations under any Included In-License. 
 7. Matters involving
General Patents and Agent Technology. Notwithstanding anything in this Agreement to the contrary, as between the Parties and irrespective of Committee involvement or otherwise, (a) Moderna shall have final decision making authority with
respect to any and all matters involving the Moderna General Patents and any Patents within the Moderna Agent Technology, and (b) Merck shall have final decision making authority with respect to any and all matters involving Merck General
Patents and any Patents within the Merck Agent Technology. 
 8. Third Party Rights. To the extent that a Third Party licensor under a
Moderna Included In-License has retained any right to [***], Moderna will use Commercially Reasonable Efforts to cause such Third Party licensor to take the actions specified by this Exhibit J in a manner consistent with the Moderna Included
In-License applicable thereto, but Moderna will not be deemed to be in breach of its obligations under this Exhibit J if, after using such Commercially Reasonable Efforts, it is unable to comply with such obligations because of actions taken or not
taken by such Third Party licensor. 
 9. Matters involving Joint Patents. The Prosecution and Maintenance, and the enforcement and
defense, of any Joint Patents shall be [***]. 
 10. Immune Potentiator Patent Application. [***] 

  
 J-5 

 EXHIBIT K 

Supply Terms 

[***] 

  
 K-1 

 EXHIBIT L 

Subcontractors and Sublicensing 

  
 L-1 

 EXHIBIT L-1 

Permitted Subcontractors 
  

					
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 L-6 

 EXHIBIT L-2 

Certain Sublicensing/Subcontracting Examples 

[***] 

  
 L-7 

 EXHIBIT M 

Terms for PCV Clinical Supply Agreement and SAV Clinical Supply Agreement 

 

			
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 M-1 

 EXHIBIT N 

Supply Terms for Merck Internal SAV Programs 

a. [***] 
  

									
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		  	[***]	  		  	

  
 N-1 

 SCHEDULE 1.235 

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 SCHEDULE 1.253 

Moderna Pre-Existing In-Licenses 

[***] 

 SCHEDULE 3.4(c)(ii) 

Initial KRAS Transition Plan 

[***] 

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 SCHEDULE 6.1(d)(iv) 

Required Manufacturing Items 
  

					
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	  	 [***]EX-10.6

 Exhibit 10.6 

A&R Option Agreement 

Confidential 
 Amended and
Restated Option Agreement 
 by and between 

ModernaTx, Inc., 
 and

 AstraZeneca AB 

June 15, 2018 

 A&R OPTION AGREEMENT 

 

 Table of Contents 

 

									
	 	 	 	  	 	  	Page	 
			
	 1.
	 	Definitions	  	 	1	 
			
	 2.
	 	Selection of Research Polypeptides and Research Targets	  	 	7	 
				
		 	2.1.	  	Research Targets as of the Amendment Effective Date	  	 	7	 
		 	2.2	  	Discontinuation of Research Targets	  	 	8	 
		 	2.3.	  	Expiration of Services Program with respect to certain Targets	  	 	9	 
			
	 3.
	 	License Grants	  	 	9	 
				
		 	3.1.	  	Licenses by Moderna	  	 	9	 
		 	3.2	  	Development License by AstraZeneca	  	 	10	 
		 	3.3	  	AstraZeneca [***] Technology Licenses by AstraZeneca	  	 	10	 
		 	3.4	  	Licenses to Discontinued Targets by AstraZeneca	  	 	11	 
		 	3.5	  	[***]	  	 	11	 
		 	3.6	  	Sublicenses	  	 	12	 
		 	3.7	  	Third-Party Agreements; Third-Party Payment Obligations	  	 	12	 
		 	3.8	  	AstraZeneca Rights in Bankruptcy	  	 	13	 
		 	3.9	  	No Implied Rights	  	 	13	 
		 	3.10	  	Distributors	  	 	13	 
			
	 4.
	 	Development Activities	  	 	14	 
				
		 	4.1	  	Designation of Product Candidates	  	 	14	 
		 	4.2	  	Development Pool Limit	  	 	14	 
		 	4.3	  	Development Pool Diligence	  	 	15	 
		 	4.4	  	Products Containing [***] Product Candidates and Product Candidates Addressing [***]	  	 	15	 
		 	4.5	  	Development Pool Meetings and Reports	  	 	16	 
		 	4.6	  	Permitted Subcontracting	  	 	17	 
			
	 5.
	 	Exclusivity	  	 	17	 
				
		 	5.1	  	[***] AstraZeneca Exclusive Target	  	 	17	 
		 	5.2	  	AstraZeneca CV Targets and the AstraZeneca Oncology Target	  	 	17	 
		 	5.4	  	Nomination of Exclusive Indications and Exclusive Routes of Administration	  	 	18	 
		 	5.5	  	Exploitation of mRNA Constructs	  	 	18	 
			
	 6.
	 	Options for Development Pool Candidates and Exercise Price	  	 	18	 
				
		 	6.1.	  	Grants of Options	  	 	18	 
		 	6.2.	  	Definition of Options	  	 	18	 
		 	6.3	  	Option Purchase Price	  	 	18	 

 A&R OPTION AGREEMENT 

 

									
		 	6.4	  	Option Exercise Period	  	 	19	 
		 	6.5	  	Option Exercise Price	  	 	19	 
		 	6.6	  	Option Exercise	  	 	19	 
		 	6.7.	  	Purchasing a Product Candidate	  	 	20	 
		 	6.8	  	Commercialization Provisions	  	 	20	 
		 	6.9	  	Application of the Put Agreement	  	 	21	 
		 	6.10	  	Option Termination on [***] Anniversary	  	 	21	 
			
	 7.
	 	Tax Matters	  	 	21	 
				
		 	7.1	  	Payments Exempt from Withholding Tax	  	 	21	 
		 	7.2	  	Payments Reduced by Withholding Taxes	  	 	21	 
		 	7.3	  	Indirect Taxes	  	 	21	 
			
	 8.
	 	Regulatory Responsibilities	  	 	21	 
				
		 	8.1	  	In General	  	 	21	 
		 	8.2	  	Regulatory Filings	  	 	21	 
		 	8.3	  	Interactions with Regulatory Authorities	  	 	21	 
		 	8.4	  	Moderna Regulatory Responsibilities Related to Manufacture	  	 	22	 
			
	 9.
	 	Intellectual Property	  	 	22	 
			
	 10.
	 	Patent Prosecution, Maintenance, Enforcement and Defense	  	 	22	 
				
		 	10.1	  	Joint Patent Committee	  	 	22	 
		 	10.2	  	Prosecution and Maintenance	  	 	23	 
		 	10.3	  	Patent Extensions	  	 	25	 
		 	10.4	  	Patent Listings	  	 	25	 
		 	10.5	  	Enforcement and Defense	  	 	25	 
		 	10.6	  	Third Party Rights	  	 	27	 
		 	10.7	  	AstraZeneca Collaboration Technology	  	 	27	 
			
	 11.
	 	Confidentiality	  	 	27	 
			
	 12.
	 	Representations and Warranties; Covenants; Limitations of Liability; Indemnification	  	 	27	 
				
		 	12.1.	  	Representations and Warranties of Each Party	  	 	27	 
		 	12.2.	  	Representations and Warranties of Moderna	  	 	28	 
		 	12.3.	  	Moderna Corporate Covenants	  	 	30	 
		 	12.4	  	Disclaimers	  	 	30	 
		 	12.5	  	No Consequential Damages	  	 	31	 
		 	12.6	  	Indemnification	  	 	31	 

 A&R OPTION AGREEMENT 

 

									
			
	 13.
	 	Term and Termination	  	 	33	 
				
		 	13.1	  	Option Agreement Term	  	 	33	 
		 	13.2	  	Termination by Moderna	  	 	33	 
		 	13.3	  	Termination by AstraZeneca	  	 	34	 
		 	13.4	  	Alternative to Termination Under Section 13.3(a)	  	 	34	 
		 	13.5	  	Effects of Termination or Expiration	  	 	35	 
		 	13.6	  	Survival	  	 	35	 
		 	13.7	  	Integrated Agreements	  	 	35	 
			
	 14.
	 	General Provisions	  	 	36	 
				
		 	14.1	  	Dispute Resolution	  	 	36	 
		 	14.2	  	Cumulative Remedies and Irreparable Harm	  	 	36	 
		 	14.3	  	Business Combination and Exclusivity	  	 	36	 
		 	14.4	  	Relationship of Parties	  	 	36	 
		 	14.5	  	Anti-Bribery and Corruption Compliance	  	 	36	 
		 	14.6	  	Compliance with Law	  	 	36	 
		 	14.7	  	Governing Law	  	 	36	 
		 	14.8	  	Counterparts; Facsimiles	  	 	37	 
		 	14.9	  	Headings	  	 	37	 
		 	14.10	  	Waiver of Rule of Construction	  	 	37	 
		 	14.11	  	Interpretation	  	 	37	 
		 	14.12	  	Binding Effect	  	 	37	 
		 	14.13	  	Assignment	  	 	37	 
		 	14.14	  	Amendment and Waiver	  	 	38	 
		 	14.15	  	Severability	  	 	38	 
		 	14.16	  	Entire Agreement	  	 	38	 

 A&R OPTION AGREEMENT 

 

 List of Exhibits and Schedules 

 

			
	Exhibit A	  	AstraZeneca CV Targets
		
	Exhibit B	  	The AstraZeneca Exclusive Target
		
	Exhibit C	  	The AstraZeneca Oncology Target
		
	Exhibit D	  	Discontinued Targets
		
	Schedule A	  	Schedule of Exercise Price Payable for each Optioned Product Candidate for each Option Exercise
		
	Schedule B	  	 Product Commercialization Schedule

 Amended and Restated Option Agreement 

This Amended and Restated Option Agreement (this “A&R Option Agreement”) is made on the Amendment Effective Date by and
between ModernaTx, Inc., a Delaware corporation (“Moderna”) and AstraZeneca AB, a company incorporated in Sweden under no. 556011-7482 with offices at SE-431 83 Mölndal, Sweden
(“AstraZeneca”). Each of Moderna and AstraZeneca may be referred to herein as a “Party” or together as the “Parties.” 

WHEREAS, Moderna has developed technology useful for the discovery, development, Manufacture, characterization, or use of therapeutic products
that function using mRNA; 
 WHEREAS, AstraZeneca is a biopharmaceutical company focused on identifying, Developing and Commercializing
innovative therapeutic products; 
 WHEREAS, AstraZeneca and Moderna entered into an Option Agreement made as of March 20, 2013 as
amended on January 10, 2015, April 10, 2018 and May 14, 2018 (the “Original Option Agreement”), pursuant to which AstraZeneca has exclusive options (but not obligations) to purchase the rights to certain mRNA Constructs
[***] up to forty (40) Polypeptides for certain Targets; 
 WHEREAS, further, pursuant to the Original Option Agreement Moderna granted
AstraZeneca certain licenses under Moderna’s intellectual property, to assist AstraZeneca in determining whether or not to exercise Options under the Original Option Agreement; 

WHEREAS, there is one Optioned Product Candidate under the Original Option Agreement; and 

WHEREAS, the Parties wish to amend and restate the Original Option Agreement as set forth herein. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein, and for other good and valuable consideration, the amount and
sufficiency of which are hereby acknowledged, the Parties hereby agree as follows: 
  

	1.	 Definitions. 

The following terms and their correlatives will have the following meanings. Capitalized terms used but not defined herein have the meanings ascribed to such
terms in the other Transaction Agreements. 
 1.1    “Activity” means with respect to a Target and a
particular indication, that there is [***]. 
 1.2    “A&R Services and Collaboration Agreement”
means that Amended and Restated Services and Collaboration Agreement entered into by the Parties as of the Amendment Effective Date. 

1.3    “AstraZeneca” has the meaning set forth in the Preamble. 

  
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 A&R OPTION AGREEMENT 

 

 1.4    “AstraZeneca CV Target” means each Target listed
on Exhibit A, unless it becomes a Discontinued Target. 
 1.5    “AstraZeneca Exclusive Target”
means the Target listed on Exhibit B [***], unless it becomes a Discontinued Target. 
 1.6    “AstraZeneca
Exclusive Target Development Polypeptide” means the Polypeptide [***] the [***] Optioned Product Candidate. 

1.7    “AstraZeneca Field” means: 

(a)    for [***] AstraZeneca Exclusive Target, [***]; 

(b)    for [***] AstraZeneca CV Target and any Collaboration mRNA Construct [***] a Research Polypeptide or a Development
Polypeptide for an AstraZeneca CV Target, the CV Field; and 
 (c)    for [***] AstraZeneca Oncology Target and any
Collaboration mRNA Construct [***] a Research Polypeptide or a Development Polypeptide for the AstraZeneca Oncology Target, the Oncology Field. 

1.8     “AstraZeneca Expanded Field Target” means [***] AstraZeneca CV Targets other than [***]. 

1.9    “AstraZeneca Oncology Target” means the Target listed on Exhibit C [***], unless it becomes
a Discontinued Target. 
 1.10    “AstraZeneca Indemnitees” has the meaning set forth in
Section 12.6(b). 
 1.11    [***] 

1.12    “AstraZeneca Option Notice” has the meaning set forth in Section 6.6. 

1.13    “Bankruptcy Code” has the meaning set forth in Section 3.8. 

1.14    “Biosimilar Application” means an application submitted to the FDA under subsection (k) of
Section 351 of the PHSA, or any analogous application submitted to a Regulatory Authority in the United States or in another country in the Territory. 

1.15    “CMC” has the meaning set forth in Section 8.4. 

1.16    “[***] Product” means a Product that contains a [***] Product Candidate. 

1.17     “[***] Product Candidate” means a product candidate that [***] For clarity, upon nomination of a
[***] Product Candidate as a Product Candidate pursuant to Section 4.1, such Product Candidate will continue to be a [***] Product Candidate for all purposes under the Transaction Agreements. 

  
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 1.18    “[***] Target” with respect to a [***] Product
Candidate, means the [***]. For clarity, [***]. 
 1.19     “Commercialization” means (a) any and
all activities directed to the Manufacturing, marketing, detailing, promotion and securing of reimbursement of a product after Regulatory Approval has been obtained (including making, having made, using, importing, selling and offering for sale such
product), and will include post-approval clinical studies, post-launch marketing, promoting, detailing, marketing research, distributing, customer service, administering commercially selling, having sold or otherwise disposing or offering to dispose
of such product, importing, exporting or transporting such product for commercial sale, and all regulatory compliance with respect to the foregoing, and (b) otherwise marketing, selling or exploiting commercially a product. 

1.20    “Commercialization Schedules” means Schedule A and the Product Commercialization Schedule,
together. 
 1.21    “Competitive Infringement” means [***]. 

1.22    “Contingent Deferred Option Purchase Payment” has the meaning set forth in Section 6.3(b).

 1.23    “Contingent Event” has the meaning set forth in Paragraph 2.2 (Schedule A). 

1.24    “Contingent Event Option Exercise Payment” has the meaning set forth in Paragraph 2.2 (Schedule
A). 
 1.25    “CV Field” means (a) the treatment, prevention, palliation, or prophylaxis in
humans of cardiovascular and cardiometabolic diseases, including [***]. The CV Field does not include vaccines.    Notwithstanding the foregoing, the Parties acknowledge and agree that, solely for the Exploitation of [***]
Product Candidates and [***] Products [***]. 
 1.26    “Development Pool” has the meaning set forth in
Section 4.1(a). 
 1.27    “Development Pool Candidate” means with respect to a Development
Polypeptide that AstraZeneca has designated for inclusion in the Development Pool in accordance with Section 4.1(a), all Collaboration mRNA Constructs [***] such Development Polypeptide, and that is not a Discontinued Product Candidate. 

1.28    “Development Polypeptide” means a Polypeptide for which a Product Candidate has been selected in
accordance with Section 4.1, and that is not a Discontinued Polypeptide. A Polypeptide will cease to be a Research Polypeptide on becoming a Development Polypeptide. 

1.29    “Distributor” has the meaning set forth in Section 3.10. 

1.30    “EU” has the meaning set forth in Paragraph 1.1 (Schedule A). 

1.31    [***] 

  
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 1.32    “Exempt Payments” has the meaning set forth in
Section 7.1. 
 1.33    “Exercise Price” means, for each Option exercise for an Optioned Product
Candidate, the Initial Payment plus the payments to be made by AstraZeneca to Moderna pursuant to Schedule A. 

1.34    “Existing Know-How” has the meaning set forth in
Section 12.2(b). 
 1.35    “Existing Patents” has the meaning set forth in Section 12.2(a).

 1.36    “FIM Date” means with respect to each Research Target and Development Polypeptide, the date
of the [***] in the first Phase 1 Study for the first Product incorporating a Collaboration mRNA Construct [***] such Development Polypeptide for such Research Target. 

1.37     “First Commercial Sale” has the meaning set forth in Paragraph 1.2 (Schedule A). 

1.38     “Generic Product” has the meaning set forth in Paragraph 1.3 (Schedule A). 

1.39    “Included Payments” has the meaning set forth in Section 7.2. 

1.40    “[***] Option Agreement Effective Date” means, with respect to a Product Candidate (or any other
associated Development Pool Candidate), the date of [***], or, if earlier, [***] such Product Candidate, in either case by or on behalf of AstraZeneca or any of its Affiliates or Sublicensees. 

1.41    “IND” means an investigational new drug application as defined in 21 U.S.C. § 312 (as
amended or replaced), or any foreign equivalent thereof. 
 1.42    “Indemnification Claim Notice” has
the meaning set forth in Section 12.6(c). 
 1.43    “Indemnified Party” has the meaning set forth
in Section 12.6(c). 
 1.44    “Indirect Taxes” means VAT, sales taxes, consumption taxes and
other similar taxes required by law to be disclosed on the invoice. 
 1.45    “Initial Options Purchase
Price” has the meaning set forth in Section 6.3(a). 
 1.46    “Initial Payment” has the
meaning set forth in Section 6.5(b). 
 1.47    “In-License
Payments” means any amounts paid or payable under any Moderna Collaboration In-License that are incurred by Moderna as a result of the grant of [***] under this A&R Option Agreement. Any such
payments will include (a) any amounts paid or payable under any Moderna Collaboration In-License as a result of the grant of [***], but excluding (i) any payments resulting from [***], (ii) any
payment based on any payments [***], and (iii) any payments based on [***], and (b) costs of [***]. 

1.48    “IP Matters” has the meaning set forth in Section 10.1(a). 

  
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 1.49    [***] 

1.50    “Joint Patent Committee” or “JPC” has the meaning set forth in
Section 10.1(a). 
 1.51    “Losses” has the meaning set forth in Section 12.6(a). 

1.52    [***] 

1.53    [***] 

1.54     “Moderna” has the meaning set forth in the Preamble. 

1.55    “Moderna General Background Patents” means any and all Moderna Background Patents that are not
[***]. 
 1.56    [***] 

1.57    “Moderna Indemnitees” has the meaning set forth in Section 12.6(a). 

1.58    [***] 

1.59    [***] 

1.60    [***] 

1.61    [***] 

1.62    [***] 

1.63    “Net Sales” has the meaning set forth in Paragraph 1.4 (Schedule A). 

1.64    “Nominated CV Field” means with respect to each Product Candidate [***] Development Polypeptide
for an AstraZeneca CV Target (and all associated Development Pool Candidates), the indications in the CV Field identified by AstraZeneca for such Product Candidate in accordance with Section 4.1(a), [***]. 

1.65     “Nominated Oncology Field” means with respect to each Product Candidate [***] Development
Polypeptide for the AstraZeneca Oncology Target (and all associated Development Pool Candidates), the indications in the Oncology Field identified by AstraZeneca for such Product Candidate in accordance with Section 4.1(a), [***]. 

1.66    “Nominated ROA” means with respect to each Product Candidate (and all associated Development Pool
Candidates), the route(s) of administration (as defined by [***] for such Product Candidate identified by AstraZeneca in accordance with Section 4.1(a), in each case, [***]. 

  
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 A&R OPTION AGREEMENT 

 

 1.67    “Oncology Field” means (a) the treatment,
prevention, palliation, or prophylaxis in humans of cancer, and (b) companion diagnostics specific to any Product Candidate or Product. The Oncology Field does not include vaccines. 

1.68    “Option” has the meaning set forth in Section 6.2. 

1.69     “Option Exercise Earn-Out” has the meaning set forth in
Paragraph 2.3(a) (Schedule A) 
 1.70    “Option Agreement Term” has the meaning set forth in
Section 13.1. 
 1.71    “Option Exercise Period” has the meaning set forth in Section 6.4.

 1.72    “Optioned Product Candidate” means a Product Candidate (including any [***] Product
Candidate) for which AstraZeneca has (i) properly provided Moderna an AstraZeneca Option Notice in the proper form, and (ii) properly paid Moderna the Initial Payment. 

1.73    “Option Purchase Price” has the meaning set forth in Section 6.3(b)(ii). 

1.74    “Original Option Agreement” has the meaning set forth in the Preamble. 

1.75    “Party” and “Parties” has the meaning set forth in the Preamble. 

1.76    “Phase 1 Study” means a clinical trial of a product, the principal purpose of which is
preliminary determination of safety in healthy individuals or patients as described under 21 C.F.R. §312.21(a) (as amended or any replacement thereof), or a similar clinical study prescribed by the Regulatory Authorities in a foreign country.

 1.77    “Phase 2 Study” has the meaning set forth in Paragraph 1.5 (Schedule A). 

1.78    “Phase 3 Study” has the meaning set forth in Paragraph 1.6 (Schedule A). 

1.79    “PHSA” has the meaning set forth in Paragraph 1.7 (Schedule A). 

1.80    [***] 

1.81     “Product Candidate” means with respect to a Polypeptide, the Collaboration mRNA Construct
constituting a Development Pool Candidate and [***] such Polypeptide that has been selected for further Development pursuant to Section 4.1(a) and that is not a Discontinued Product Candidate. For clarity, subject to the adjustments provided
for in Section 4.4, upon nomination of a [***] Product Candidate as a Product Candidate pursuant to Section 4.1, such [***] Product Candidate will be a Product Candidate (but will continue to be a [***] Product Candidate). 

1.82    “Regulatory Exclusivity Period” means with respect to a Product in a country, the period of time
during which (a) AstraZeneca or any of its Affiliates or Sublicensees has been granted the exclusive legal right by a Regulatory Authority (or is otherwise entitled to the exclusive legal right by operation of Law) in such country to market and
sell the Product, or (b) the data and 

  
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 A&R OPTION AGREEMENT 

 

 
information submitted by AstraZeneca or any of its Affiliates or Sublicensees to the relevant Regulatory Authority in such country for purposes of obtaining Regulatory Approval may not be
disclosed, referenced or relied upon in any way by such Regulatory Authority (including by relying upon the Regulatory Authority’s previous findings regarding the safety or effectiveness of the Product) to support the Regulatory Approval or
marketing of any product by a Third Party in such country. 
 1.83    “Research Polypeptide” means any
Polypeptide for a Research Target that has been selected for evaluation as a part of the Services Program in accordance with Section 2 of the A&R Services and Collaboration Agreement, and that is not a Development Polypeptide or a
Discontinued Polypeptide. 
 1.84    “Research Targets” means the AstraZeneca CV Targets, the
AstraZeneca Oncology Target and the AstraZeneca Exclusive Target, and will not include any Discontinued Targets (and further, any Target definitions that underlie the definitions of the AstraZeneca Exclusive Target, the AstraZeneca CV Targets or the
AstraZeneca Oncology Target will not include any Discontinued Targets). 
 1.85    “Research Tool”
means any technology which is designed, developed and used solely for performing research and drug discovery activities, excluding (a) research and drug discovery activities directed to mRNA Technology and (b) the diagnosis, treatment,
prevention, palliation, or prophylaxis of human diseases and conditions. 
 1.86    “Selling Party” has
the meaning set forth in Paragraph 1.8 (Schedule A). 
 1.87    “Tax” and “Taxation”
means any form of tax or taxation, levy, duty, charge, social security charge, contribution, or withholding of whatever nature (including any related fine, penalty, addition to tax, surcharge or interest) imposed by, or payable to, a Tax Authority.
Notwithstanding anything herein to the contrary, Taxes will not include any Indirect Taxes. 
 1.88    “Tax
Authority” or “Tax Authorities” means any government, state or municipality, or any local, state, federal or other fiscal, revenue, customs, or excise authority, body or official anywhere in the world, authorized to levy
tax. 
 1.89    “Territory” means worldwide. 

1.90    “Third Party Claims” has the meaning set forth in Section 12.6(a). 

1.91    “Valid Claim” has the meaning set forth in Paragraph 1.9 (Schedule A). 

1.92    “[***] Optioned Product Candidate” means the Optioned Product Candidate [***] for a Polypeptide
for [***] existing as of the Amended Effective Date. 
  

	2.	 Research Targets. 

2.1    Research Targets as of the Amendment Effective Date. 

(a)    The AstraZeneca Exclusive Target. [***] AstraZeneca Exclusive Target as of the Amendment Effective Date is
set forth in Exhibit B. 
 (b)    AstraZeneca CV Targets. [***] AstraZeneca CV Targets as of the Amendment
Effective Date are set forth on Exhibit A. 
 (c)    AstraZeneca Oncology Target. [***] AstraZeneca
Oncology Target as of the Amendment Effective Date is set forth on Exhibit C. 
 (d)    Research Targets.
As of the Amendment Effective Date, there are [***] Research Targets: the AstraZeneca Exclusive Target, [***] AstraZeneca CV Targets and the AstraZeneca Oncology Target. Each of these Targets will remain a Research Target unless and until it becomes
a Discontinued Target in accordance with the Transaction Agreements. Following the Amendment Effective Date AstraZeneca does not have any rights to nominate (or re-nominate) any other Target as a Research
Target. For certain purposes in connection with [***] Product Candidates, [***] Research Targets will be treated as [***] Research Targets as set out in Section 4.4. 

  
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 2.2    Discontinuation of Research Targets. 

(a)    Subject as provided in Section 4.4, a Research Target may become a Discontinued Target under the Transaction
Agreements as follows (as well as otherwise expressly provided in any of the Transaction Agreements, including Section 2.2(c) of the A&R Services & Collaboration Agreement), with the consequences set forth in Section 3.4 and
elsewhere in the Transaction Agreements: 
 (i)    If a Research Target is excluded from the scope of the Services
Program before [***] pursuant to Section 2.2(c) of the A&R Services & Collaboration Agreement, such Research Target will automatically become a Discontinued Target (and all Research Polypeptides for such Discontinued Target will
become Discontinued Polypeptides and all Collaboration mRNA Constructs [***] such Research Polypeptides for such Discontinued Target will become Discontinued Product Candidates); and 

(ii)    If (A) no Product Candidate [***] a Research Polypeptide for a Research Target is included by AstraZeneca in
the Development Pool before the [***], or (B) a Development Polypeptide for a Research Target is no longer included in the Development Pool, then in each case ((A) and (B)), such Research Target will automatically become a Discontinued
Target (and all Research Polypeptides or Development Polypeptides, as applicable, for such Discontinued Target will become Discontinued Polypeptides and all Collaboration mRNA Constructs, Product Candidates, Development Pool Candidates [***] such
Research Polypeptide or Development Polypeptide, as applicable, will become Discontinued Product Candidates), unless for such Research Target there is (1) a different Research Polypeptide then in the Services Program; (2) another
Development Polypeptide then in the Development Pool or (3) an Optioned Product Candidate. 
 (b)    The license
grants set forth in Section 3.1(a) and 3.1(b) will no longer apply with respect to any Discontinued Target, Discontinued Polypeptide or Discontinued Product Candidate and Moderna will be free to Exploit any and all mRNA Constructs and
associated products for any Polypeptide for a Discontinued Target alone or with others with no obligation to AstraZeneca. 

  
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 A&R OPTION AGREEMENT 

 

 (c)    For clarity, notwithstanding the provisions of this
Section 2.2, nothing in the Transaction Agreements is intended to prevent AstraZeneca from Exploiting any Discontinued Target or Discontinued Polypeptide or any mRNA Construct (other than a Collaboration mRNA Construct) coding for a
Discontinued Polypeptide (subject to Sections 5.2(a) and 5.2(b)), or any other Polypeptide for such Discontinued Target outside of the Transaction Agreements; provided, that any such Exploitation does not use Moderna Technology except as expressly
permitted by the Transaction Agreements. 
 2.3    Expiration of Services Program with respect to certain
Targets. The Parties hereby acknowledge and agree that the Services Program with respect to the Targets listed in Exhibit D has been prior to the Amendment Effective Date or will be with effect on the Amendment Effective Date,
terminated and that each such Target is a Discontinued Target (and, for clarity, all Research Polypeptides for such Discontinued Targets are Discontinued Polypeptides and all Collaboration mRNA Constructs [***] such Research Polypeptides are
Discontinued Product Candidates); provided that the Parties agree that they wish to continue collaborating with respect to the Discontinued Targets [***] that until the earlier to occur of (a) [***] and (b) the expiration of the Services
Program Term, notwithstanding such Targets are Discontinued Targets, each Party will not (1) and will ensure that its Affiliates will not, itself or with or for any Third Party, or (2) [***]. 

 

	3.	 License Grants.  

3.1    Licenses by Moderna.  

(a)    Subject to the terms and conditions of this A&R Option Agreement, including Section 4.4, Moderna hereby
grants to AstraZeneca a [***] (except as set forth in Section 13.5), worldwide, royalty-bearing right and license, with the right to grant sublicenses pursuant to Section 3.6 only, under the Moderna Technology, to Exploit: 

(i)    with respect to the AstraZeneca Exclusive Target, mRNA Constructs [***] any and all Polypeptides for the
AstraZeneca Exclusive Target for use in the applicable AstraZeneca Field; 
 (ii)    on a Target-by-Target basis, with respect to each AstraZeneca CV Target (and separately with respect to any [***] Target) and the AstraZeneca Oncology Target, Collaboration mRNA
Constructs [***] Research Polypeptides for such Target for use in the applicable AstraZeneca Field; and 
 (iii)    on
a Product Candidate-by-Product Candidate basis, Collaboration mRNA Constructs comprising such Product Candidate (and all associated Development Pool Candidates) for use
in the AstraZeneca Field for such Product Candidate. 
 The licenses set forth in Section 3.1(a) are
(A) co-exclusive with Moderna (solely to the extent necessary for Moderna to exercise its retained rights pursuant to Section 3.1(b) with respect to the Manufacture of such Collaboration mRNA
Constructs), and (B) exclusive (including with respect 

  
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 A&R OPTION AGREEMENT 

 

 
to Moderna and its Affiliates) with respect to all other Exploitation of such Collaboration mRNA Constructs, in each case in the applicable AstraZeneca Field. For clarity, Discontinued Targets,
Discontinued Polypeptides and Discontinued Product Candidates are excluded from the scope of the licenses set forth in this Section 3.1(a). 

(b)    Notwithstanding the exclusive licenses granted to AstraZeneca pursuant to Section 3.1(a), Moderna retains
rights under the [***] to perform the Services, to Manufacture pursuant to the Transaction Agreements and the Master Supply Agreements and to undertake the Development activities as set forth in Sections 5.1 and 5.2.    For
clarity, (i) subject to the exclusive licenses granted to AstraZeneca pursuant to Section 3.1(a) and subject to Section 5, Moderna may Exploit (alone or with other(s) by license or otherwise) any mRNA Constructs other than
Collaboration mRNA Constructs outside the scope of the Transactions Agreements, and (ii) Moderna may Manufacture under the co-exclusive license grant only (A) for AstraZeneca and (B) to exercise
its rights pursuant to this Section 3.1(b). 
 (c)    With respect to the foregoing grants under the [***],
AstraZeneca agrees that: 
 (i)    it will not, and will not sublicense or otherwise authorize its Affiliates or
Sublicensees to, Commercialize any Collaboration mRNA Construct [***] a Polypeptide for a Research Target (including Manufacture of such Collaboration mRNA Constructs for Commercialization) unless and until AstraZeneca has (x) identified a
Product Candidate [***] such Polypeptide in a properly provided AstraZeneca Option Notice in the proper form, and (y) properly paid Moderna ten million dollars (US$ 10,000,000) whereupon the Commercialization Schedules will apply to the
Commercialization of such Product Candidate (and associated Products) and the other items specified thereon; 

(ii)    it will not, and it will not sublicense or otherwise authorize its Affiliates or Sublicensees to, clinically
Develop any Collaboration mRNA Construct for a Research Polypeptide; and 
 (iii)    it will not, and it will not
sublicense or otherwise authorize its Affiliates or Sublicensees to, practice the license to Manufacture Moderna mRNA API except in the circumstances described in Section 4.1 of the A&R Services and Collaboration Agreement. 

(d)    [***] 

3.2    Development License by AstraZeneca. Subject to the terms and conditions of the Transaction Agreements,
AstraZeneca hereby grants to Moderna a [***], non-exclusive, worldwide, royalty-free right and license in the applicable AstraZeneca Field, with the right to grant sublicenses pursuant to Section 3.6,
under the AstraZeneca Background Technology and AstraZeneca Collaboration Technology, solely to perform the Services and Development Pool Services in accordance with the terms of the Transaction Agreements. 

3.3    AstraZeneca [***] Technology Licenses by AstraZeneca. Subject to the terms and conditions of the Transaction
Agreements, AstraZeneca hereby grants to Moderna a [***], non-exclusive, worldwide right and license, with the right to grant sublicenses pursuant to Section 3.6 only, under the AstraZeneca [***]
Technology, to Exploit any mRNA Constructs other than any mRNA Construct [***] a Polypeptide for a Research Target. If Moderna grants a sublicense to a Third Party, Moderna will [***]. 

  
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 3.4    Data and Results for Discontinued Targets; Assignments and
Licenses to Discontinued Targets by AstraZeneca. 
 (a)    With respect to each Discontinued Target as of the
Amendment Effective Date or, with respect to any Target that becomes a Discontinued Target after the Amendment Effective Date, promptly (but in any event within [***] Business Days) following the Amendment Effective Date, or the date on which such
Discontinued Target becomes a Discontinued Target, respectively, AstraZeneca will, to the extent it has not done so previously, provide Moderna with a copy of all data and results generated by or on behalf of AstraZeneca in the course of
AstraZeneca’s performance of the Services Program with respect to such Discontinued Target and the applicable Discontinued Polypeptides. With respect to each Discontinued Target as of the Amendment Effective Date and, with respect to any Target
that becomes a Discontinued Target after the Amendment Effective Date, AstraZeneca does hereby assign and will assign to Moderna all right, title and interest in and to any Patents within the AstraZeneca Collaboration Technology that relate solely
to such Discontinued Target (including the data and results that relate solely to such Discontinued Target provided pursuant to this Section 3.4(a)), to the extent it has not done so previously. 

(b)    With respect to each Discontinued Target (and subject to Section 2.2(b)), AstraZeneca will grant (and does
hereby grant), to Moderna a [***], non-exclusive, worldwide, royalty-free right and license, with the right to grant sublicenses pursuant to Section 3.6 only, under the AstraZeneca Collaboration
Technology (other than the AstraZeneca Collaboration Technology assigned pursuant to Section 3.4(a), but including all other data and results with respect to such Discontinued Target provided pursuant to Section 3.4(a) and under the
AstraZeneca [***] Technology, to Exploit any mRNA Construct for a Polypeptide to such Discontinued Target (including any Discontinued Product Candidates or Discontinued Polypeptides for such Discontinued Target) in any field. 

3.5    [***] 

(a)    [***] 

(b)    [***] 

(c)    [***] 

(d)    [***] 

  
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 3.6    Sublicenses. 

(a)    Sublicensing Rights. Each Party will have the right to grant sublicenses, through multiple tiers of
sublicensees, under the licenses granted in Sections 3.1, 3.2, 3.3, and 3.4, in full or in part, to its Affiliates or a Third Party, provided, that as a condition precedent to and requirement of any such sublicense: 

(i)    In the case of a sublicense to a Third Party, any such sublicense to a Third Party must be pursuant to a written
agreement. The Party granting the sublicense will provide the other Party with a redacted copy of any sublicense agreement with a Sublicensee within [***] days of execution thereof; 

(ii)    The Party granting the sublicense will remain responsible for (i) its obligations under the Transaction
Agreements (including with respect to the Commercialization Schedules) even if such obligations are to be performed by a Sublicensee and (ii) adherence by such Sublicensee of any provisions of the Transaction Agreements applicable to the
activities of such Third Party as a sublicensee of such Party; 
 (iii)    Any such Sublicensee will agree in writing
to be bound by substantially similar obligations as the Party granting the sublicense hereunder with respect to the activities of such Sublicensee within the scope of the license to such Party hereunder (and not with respect to any other
activities), including Know-How disclosure obligations of such Party hereunder with respect to the activities of such Sublicensee hereunder; and 

(iv)    To the extent that a Party grants a sublicense under any intellectual property subject to a Third Party in-license, such sublicense (and such sublicensee) will be subject to such Third Party in-license. 

(b)    Transfer. The licenses granted in Sections 3.1, 3.2, 3.3, 3.4 and 3.5 are transferable only upon a
permitted assignment of this A&R Option Agreement in accordance with Section 14.13. 
 3.7    Third-Party
Agreements; Third-Party Payment Obligations. 
 (a)    [***] 

(b)    [***] 

  
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 A&R OPTION AGREEMENT 

 

 3.8    AstraZeneca Rights in Bankruptcy. All rights and licenses
granted pursuant to any section of this A&R Option Agreement are, and will be deemed to be, licenses of rights to “intellectual property” (as defined in Section 101(35A) of title 11 of the United States Code, 11 U.S.C.
§ 101, et seq (the “Bankruptcy Code”)) and of any similar provisions of applicable Laws under any other jurisdiction. Moderna agrees that AstraZeneca, as a licensee of such rights and licenses under this A&R
Option Agreement, will retain and may fully exercise all of its rights and elections under the Bankruptcy Code (including under Section 365(n) of the Bankruptcy Code). 

(a)    Embodiments of Intellectual Property. AstraZeneca will have all rights to embodiments of the intellectual
property licensed to AstraZeneca under this A&R Option Agreement, as set forth in Section 365(n) of the Bankruptcy Code. 

(b)    Effect of Bankruptcy Filing. The Parties further agree that, in the event of the commencement of a
bankruptcy proceeding by or against Moderna under the Bankruptcy Code or analogous provisions of applicable Law outside of the United States, then unless or until this A&R Option Agreement is rejected or deemed rejected, Moderna or its trustee,
pursuant to Section 365(n) of the Bankruptcy Code and upon the written request of AstraZeneca: 
 (i)    will
perform this A&R Option Agreement; or 
 (ii)    [***] 

(c)    Reservation of Rights. Nothing in this Section 3.8 will limit or restrict, or will be construed to
limit or restrict, the rights of AstraZeneca under Section 365(n) of the Bankruptcy Code, all of which rights are hereby expressly reserved. 

3.9    No Implied Rights. No license, sublicense or other right is or will be created or granted hereunder by
implication, estoppel or otherwise. Any licenses, sublicenses or rights will be granted only as expressly provided in the Transaction Agreements. Neither Party nor any of its Affiliates will use or practice any
Know-How, Materials or Patents licensed or provided to such Party or any of its Affiliates outside the scope of or otherwise not in compliance with the rights and licenses granted to such Party and its
Affiliates under the Transaction Agreements. For clarity, neither Party will be subject to any non-use or non-disclosure obligations with respect to Know-How or Materials if and to the extent that Section 7.1(c) of the A&R Services and Collaboration Agreement applies to such Know-How or Materials. 

3.10    Distributors. AstraZeneca will have the right, in its sole discretion, to appoint its Affiliates, and
AstraZeneca and its Affiliates will have the right, in their sole discretion, to appoint any other Persons in the Territory or in any country of the Territory, to distribute, market and sell the Products (with or without packaging rights), in
circumstances where the Person purchases its requirements of Products from AstraZeneca or its Affiliates but does not otherwise make any royalty or other payment to AstraZeneca with respect to its intellectual property rights or Products (including
Moderna Technology). Where AstraZeneca or its Affiliates appoints such a Person and such Person is not an Affiliate of AstraZeneca, that Person will be a “Distributor” for purposes of the Transaction Agreements. The term
“packaging rights” in this Section 3.10 will mean the right for the Distributor to package Products supplied in unpackaged bulk form into individual
ready-for-sale packs and a Distributor for Moderna will have a corresponding meaning. 

  
 13 

 A&R OPTION AGREEMENT 

 

	4.	 Development Activities. 

4.1    Designation of Product Candidates. 

(a)    Subject to Section 4.2, and Section 4.4 with respect to [***] Product Candidates, on a Research Polypeptide-by-Research Polypeptide basis, prior to the expiration of the Services Period for such Research Polypeptide, AstraZeneca may elect by written notice to Moderna to
designate one Collaboration mRNA Construct [***] such Research Polypeptide as a Product Candidate for further Development under this A&R Option Agreement, provided that such Collaboration mRNA Construct has satisfied the applicable [***]
Criteria for such Research Polypeptide, and on such designation such Research Polypeptide will cease to be a Research Polypeptide and will become a Development Polypeptide. Such designation will identify the (i) Product Candidate (including
[***]), (ii) Research Target, (iii) Development Polypeptide, (iv) the indications in the CV Field or Oncology Field, as applicable, which have Activity with respect to the applicable Research Target and for which AstraZeneca reasonably
believes could be addressed by a Product incorporating such Product Candidate (or any associated Development Pool Candidate), and (v) the route(s) of administration (as defined [***] for which AstraZeneca intends on Developing a Product
incorporating such Product Candidate. Upon any such designation, each such Product Candidate, and all other Collaboration mRNA Constructs [***] such Development Polypeptide, will each be a “Development Pool Candidate”
hereunder, and all Development Polypeptides, Product Candidates and other Development Pool Candidates existing at any one time until the [***] anniversary of the Implementation Date are collectively referred to herein as
the “Development Pool.” If for a Research Polypeptide, a Product Candidate [***] such Research Polypeptide is not included by AstraZeneca in the Development Pool before the end of the applicable Services Period for such
Research Polypeptide, then such Research Polypeptide will automatically become a Discontinued Polypeptide and all mRNA Constructs [***] such Research Polypeptide will automatically become Discontinued Product Candidates. 

(b)    Upon termination of this A&R Option Agreement or the [***] anniversary of the Implementation Date, (i) the
Development Pool will end and any Development Pool Candidates remaining therein and their associated Development Polypeptides will automatically become Discontinued Product Candidates and Discontinued Polypeptides, respectively, and (ii) those
Research Targets having a Development Polypeptide in the Development Pool will become Discontinued Targets, except for any such Research Target that has an Optioned Product Candidate. 

4.2    Development Pool Limit. 

(a)    The number of Development Polypeptides (and the number of Product Candidates therefor) in the Development Pool each
may not exceed [***] at any one time unless otherwise agreed by Moderna. 

  
 14 

 A&R OPTION AGREEMENT 

 

 (b)    During the Services Program Term, AstraZeneca may, on written
notice to Moderna, (i) elect to [***], or (ii) elect to [***]. If AstraZeneca makes an election under the preceding clause (ii), subject to Section 4.2(a), AstraZeneca can [***]. 

4.3    Development Pool Diligence. On a Development
Polypeptide-by-Development Polypeptide basis, for as long as such Development Polypeptide is in the Development Pool, AstraZeneca, directly or through one or more of its
Affiliates or permitted subcontractors, will use Commercially Reasonable Efforts to Develop a Product Candidate for such Development Polypeptide so as to achieve the [***] Option Agreement Effective Date. The Parties acknowledge that the principal
Development activities with respect to each Development Polypeptide during such period will be [***]. 

4.4    Products [***] Collaboration mRNA Constructs and Product Candidates [***]. 

This Section 4.4 will modify how the terms of the Transaction Agreements, including the Options and Schedule A, are applied with respect to certain
Research Targets, Research Polypeptides, Development Polypeptides, Collaboration mRNA Constructs, Products and Product Candidates. 

(a)    Prior to the expiration of the Services Program Term, AstraZeneca may elect to Exploit a [***] Product Candidate
that contains [***] Collaboration mRNA Constructs, [***], as follows: 
 (i)    AstraZeneca may elect to Develop [***]
as a [***] Product Candidate by providing written notice to Moderna of same, which notice will include the Collaboration mRNA Constructs to be included in such [***] Product Candidate, which may be [***]. 

(ii)    Each [***] a Collaboration mRNA Construct in such [***] Product Candidate will be treated as [***] Research
Polypeptide for all purposes under the Transaction Agreements, (including [***]). 
 (iii)    [***] must be a Research
Target but with respect to a [***] Product Candidate, the [***] addressed by such [***] Product Candidate will be a [***] Target and treated as [***] Research Target for all purposes under the Transaction Agreements (except [***]). For example,
[***], provided that if [***]. Development Pool Candidates will be used in connection with [***] Product Candidate for [***] AstraZeneca Exclusive Target. 

(iv)    If AstraZeneca selects for Development a [***] Product Candidate comprised of [***], on and following the
selection of such [***], (A) [***] and (B) [***]. 
 (v)    If AstraZeneca elects to Develop a [***] Product Candidate
comprised of [***], upon such [***] Product Candidate [***], (A) the [***] and (B) the [***]. 
 (b)    AstraZeneca
may elect to [***], as follows: 
 (i)    [***] 

(ii)    [***] 

  
 15 

 A&R OPTION AGREEMENT 

 

 (c)    With respect to any [***] Product Candidate or [***] Product, the
following will apply: 
 (i)    Subject to clause (iv) below, to have the right to Develop and Commercialize a
[***] Product Candidate and [***] Product after the [***] Option Agreement Effective Date, AstraZeneca will be required to [***]. 

(ii)    Subject to clause (iv) below, the Contingent Event Option Exercise Payments under Paragraph 2.2
(Schedule A) and the Option Exercise Earn-Out payments under Paragraph 2.3 (Schedule A) after Option exercise will be [***]; and 

(iii)    Subject to clause (iv) below, the exclusivity obligations in Section 5, and the license grants in
Section 3.1 will be [***]; 
 (iv)    If AstraZeneca wishes to Develop a [***] Product Candidate, but also wishes
to [***], AstraZeneca may by written notice to Moderna [***], elect to [***] under the Transaction Agreements, [***], the following will apply: 

(A)    To have the right to Develop and Commercialize after the [***] Option Agreement Effective Date, a [***] Product
Candidate comprised [***], AstraZeneca will be required to exercise an Option (and for clarity, pay the Initial Payment for such Option exercise as provided in this A&R Option Agreement) for [***], but will not be required to exercise an Option
for [***] Product Candidate [***]. 
 (B)    Each Contingent Event Option Exercise Payment under Paragraph 2.2
(Schedule A) will be payable for each [***], provided that [***]. For example, [***]. 
 (C)    With respect to
[***], the license grants and exclusivity obligations under the Transaction Agreements for [***] will apply to [***].    With respect to [***], the license grants and exclusivity obligations under the Transaction Agreements [***]
will apply only to the [***] Product Candidate. 
 4.5    Development Pool Meetings and Reports. 

(a)    [***] during each Contract Year until the end of the [***] Contract Year, within [***] days of Moderna’s
written request, the Parties will meet in person [***] for AstraZeneca to provide Moderna with an update on the Development of Product Candidates in the Development Pool. During such meeting, AstraZeneca will disclose to Moderna a summary of all
material information regarding such Development. 
 (b)    AstraZeneca will prepare and maintain, and will cause its
Affiliates to prepare and maintain, reasonably complete and accurate records regarding the Development of Product Candidates in the Development Pool. AstraZeneca will provide to Moderna a reasonably detailed report regarding such efforts at least
[***] each Calendar Quarter every Contract Year from the Implementation Date while the Development Pool is in existence. Such report will contain sufficient detail to enable Moderna to assess AstraZeneca’s compliance with its Development
obligations in Section 4.3, including summary information relating to [***]. In addition to the foregoing, AstraZeneca will provide Moderna with interim information regarding any such activities as Moderna may reasonably request from time to
time 

  
 16 

 A&R OPTION AGREEMENT 

 

 4.6    Permitted Subcontracting. Subject to the other terms of the
Transaction Agreements, including Section 2.12 of the A&R Services and Collaboration Agreement, Moderna may subcontract the Development Pool Services (if any) to a Third Party, AstraZeneca may subcontract any Development activities to a
Third Party, and each Party may otherwise subcontract any of its activities to be performed under this A&R Option Agreement to an Affiliate, in each case provided that (a) no such permitted subcontracting shall relieve the subcontracting
Party of any of its obligations (except to the extent satisfactorily performed by such subcontractor) and (b) any such Third Party will have entered into a written agreement with such Party that includes terms and conditions protecting and
limiting use and disclosure of Confidential Information and Materials and Know-How at least to the same extent as under this A&R Option Agreement and the A&R Services and Collaboration Agreement, and
requiring such Third Party and its personnel to assign to such Party all right, title and interest in and to any Patents, Know-How and Materials created, conceived or developed in connection with the
performance of subcontracted activities to the extent required to Develop and Commercialize Product Candidates. Any such subcontracting activities will be [***]. To the extent that any subcontractor needs a sublicense to perform the Development Pool
Services, Section 3.6 will apply. 
  

	5.	 Exclusivity. 

5.1    [***] AstraZeneca Exclusive Target. From the Implementation Date until the earlier of (a) [***] and
(b) the date on which [***] AstraZeneca Exclusive Target becomes a Discontinued Target, Moderna will not [***]. This Section 5.1 will not preclude Moderna (alone or by or with other(s) by license or otherwise) from conducting such assays
or other research as reasonably necessary to maintain compliance with this Section 5.1. 
 5.2    AstraZeneca CV
Targets and the AstraZeneca Oncology Target. 
 (a)    On an AstraZeneca CV Target-by-AstraZeneca CV Target basis or with respect to the AstraZeneca Oncology Target, until the earlier to occur of (i) [***] with respect to a Product Candidate [***] a Development Polypeptide for such
Target and (ii) the date on which such Target becomes a Discontinued Target, each Party will not [***] for such Research Target for use in the CV Field (with respect to AstraZeneca CV Targets) or the Oncology Field (with respect to the
AstraZeneca Oncology Target), in each case other than, with respect to Moderna, as a part of the Services, Development Pool Services (if applicable) and Manufacturing activities and, with respect to AstraZeneca, as a part of the Exploitation of
Collaboration mRNA Constructs, in each case as provided for in the Transaction Agreements. 
 (b)    On an AstraZeneca
CV Target-by-AstraZeneca CV Target basis or with respect to the AstraZeneca Oncology Target, from [***] with respect to a Product Candidate [***] a Development
Polypeptide for such Target until the earlier to occur of (i) [***] and (ii) the date on which such Target becomes a Discontinued Target, each Party will not [***] for [***] AstraZeneca CV Target or AstraZeneca Oncology Target, as applicable
for use in (A) the Nominated CV Field (with respect to AstraZeneca CV Targets) or the Nominated Oncology Field (with respect to the 

  
 17 

 A&R OPTION AGREEMENT 

 

 
AstraZeneca Oncology Target), or (B) the applicable AstraZeneca Field using the Nominated ROA, in each case ((A) or (B)) other than, with respect to Moderna, as a part of the Services,
Development Pool Services (if applicable) and Manufacturing activities and, with respect to AstraZeneca, as a part of the Exploitation of Collaboration mRNA Constructs, in each case as provided for in the Transaction Agreements. 

5.3    Development Polypeptides. On a
Polypeptide-by- Polypeptide basis, from the date on which a Polypeptide becomes a Development Polypeptide, until the earlier to occur of (i) [***] and (ii) the date
on which such Development Polypeptide becomes a Discontinued Polypeptide, each Party will not [***] such Development Polypeptide for use in any field, in each case other than, with respect to Moderna, as a part of the Services, Development Pool
Services (if applicable) and Manufacturing activities and, with respect to AstraZeneca, as a part of the Exploitation of Collaboration mRNA Constructs, in each case as provided for in the Transaction Agreements. 

5.4    [***].    For each Research Target (other than the AstraZeneca Exclusive Target),
AstraZeneca will, on or before (but no earlier than [***] days before) [***] for any Product [***] a Development Polypeptide for such Target [***]. At Moderna’s request AstraZeneca will provide Moderna with such information and data as is
necessary for Moderna to [***]. If there is a dispute as to [***], Moderna shall provide AstraZeneca with written notice thereof within [***] after Moderna’s receipt of AstraZeneca’s update and the Parties will discuss and attempt to
resolve the dispute at the next meeting of the JSC. In the event the JSC is unable to resolve the dispute, [***] shall apply. 

5.5    [***] 
  

	6.	 Options for Development Pool Candidates and Exercise Price. 

6.1    Grant of Options. On the Implementation Date, Moderna granted to AstraZeneca pursuant to the Original
Option Agreement, forty (40) identical Options to purchase a Product Candidate (and all associated Development Pool Candidates) in exchange for the Option Purchase Price for each such Option. 

6.2    Definition of Options. AstraZeneca will have the right to Develop and Commercialize up to forty
(40) Product Candidates (and all associated Development Pool Candidates) in the applicable AstraZeneca Field if (i) AstraZeneca provides Moderna with the AstraZeneca Option Notice and (ii) AstraZeneca pays Moderna the Exercise Price
pursuant to Section 6.5, whereupon the Commercialization Schedules will apply (each an “Option” and collectively the “Options”). As of the Amendment Effective Date, AstraZeneca has exercised one
Option to purchase a Product Candidate for [***] and there are thirty-nine remaining Option under this A&R Option Agreement. 

6.3    Option Purchase Price. 

(a)    Initial AstraZeneca Payment for the Options. Under the Original Option Agreement, AstraZeneca paid to
Moderna, a one-time payment of [***] for each of the forty (40) Options, for an aggregate amount equal to [***] (such aggregate amount, the “Initial Options Purchase Price”). Such
payments are non-refundable and non-creditable and not subject to set-off. 

  
 18 

 A&R OPTION AGREEMENT 

 

 (b)    Contingent Deferred Option Purchase Payments. 

(i)    AstraZeneca has made two payments to Moderna totaling One Hundred Twenty Million Dollars (U.S.$120,000,000) upon
the occurrence of two Development Events (as defined and pursuant to the Original Option Agreement) related to [***] (each such payment, a “Contingent Deferred Option Purchase Payment”). 

(ii)    Definition. The “Option Purchase Price” for each of the forty (40) Options will be
equal to the sum of (1) [***] plus (2) the fair market value of the right to receive [***] of the Contingent Deferred Option Purchase Payments paid under the Original Option Agreement. 

6.4    Option Exercise Period. With respect to any Development Polypeptide, each Option may be exercised by
AstraZeneca during the period commencing on the date that a Development Polypeptide and associated Product Candidate is included in the Development Pool until [***] days after the [***] Option Agreement Effective Date for the first Product Candidate
(or any other Collaboration mRNA Construct) [***] such Development Polypeptide (the applicable “Option Exercise Period” for such Development Polypeptide), subject to Section 6.9. 

6.5    Option Exercise Price. 

(a)    Exercise Price. AstraZeneca will pay to Moderna the Exercise Price upon the exercise of each Option, as
further set forth in Section 6.5(b) and Schedule A for the Optioned Product Candidate (and associated other Development Pool Candidates) subject to such Option. 

(b)    Initial Payment of the Exercise Price. For each Option, within [***] of AstraZeneca’s issuance of an
AstraZeneca Option Notice, AstraZeneca will pay to Moderna Ten Million Dollars (U.S.$10,000,000) (the “Initial Payment” for each Option exercised). Such payment will be non-refundable and
non-creditable and not subject to set-off, subject to Section 11.16 of the A&R Services and Collaboration Agreement. As of the Amendment Effective Date,
AstraZeneca has paid Moderna [***] in connection with the exercise of [***] to purchase [***] (and associated other Development Pool Candidates) for the AstraZeneca Exclusive Target. 

6.6    Option Exercise. Upon AstraZeneca (a) providing notice to Moderna in writing which Product Candidate is
being selected by AstraZeneca to be an Optioned Product Candidate hereunder (along with all associated Development Pool Candidates), and identifying the applicable Product Candidate and Development Polypeptide and the applicable AstraZeneca
Field (“AstraZeneca Option Notice”), and (b) paying to Moderna the Initial Payment, whereupon the Commercialization Schedules will apply to the Commercialization of such Product Candidate and the other items specified
thereon, an Option will be exercised. Moderna will only have the right to object to an AstraZeneca Option Notice if the Product Candidate selected by AstraZeneca does not satisfy the definition of a Product Candidate in Section 1.81 or the
AstraZeneca Option Notice does not otherwise comply with the notice requirements in this Section 6.6. If Moderna properly objects to such AstraZeneca Option Notice in writing within [***] of receipt thereof, the Parties will discuss
Moderna’s objections. If Moderna fails to properly object to such AstraZeneca Option Notice in writing within [***] of receipt thereof, AstraZeneca may proceed with the Product Candidate selected. A separate AstraZeneca Option Notice and
payment of the Initial 

  
 19 

 A&R OPTION AGREEMENT 

 

 
Payment will be required for each Development Polypeptide and the first Product Candidate with respect thereto optioned by AstraZeneca pursuant to this Section 6.6. If AstraZeneca does not
issue an AstraZeneca Option Notice and pay the Initial Payment with respect to a Product Candidate [***] a Development Polypeptide during the Option Exercise Period for such Development Polypeptide, the right to exercise an Option and other rights
granted to AstraZeneca under this A&R Option Agreement and the other Transaction Agreements with respect to such Product Candidate will terminate in full and will no longer be exercisable and such Development Polypeptide and the Product
Candidate and other Development Pool Candidates for such Development Polypeptide will be automatically re-designated as a Discontinued Polypeptide and Discontinued Product Candidates, respectively. 

6.7    Purchasing a Product Candidate. If AstraZeneca wishes to file an IND for a Product Candidate but at the time
of such filing forty (40) Product Candidates [***] forty (40) Development Polypeptides are being further Developed or Commercialized in accordance with the Commercialization Schedules, the Parties will discuss in good faith how AstraZeneca
may purchase the right to continue to Develop and Commercialize an additional Product Candidate for a purchase price equal to the fair market value of such Product Candidate (which purchase price will include at a minimum an initial payment of
[***])). There will not be more than [***] of such purchases. 
 6.8    Commercialization Provisions. 

(a)    Immediately upon AstraZeneca’s delivery of an AstraZeneca Option Notice with respect to a Development Pool
Candidate, and AstraZeneca paying Moderna the Initial Payment with respect to a Product Candidate, AstraZeneca (or an Affiliate designated by AstraZeneca) will have the right to Commercialize such Optioned Product Candidate (and all associated
Development Pool Candidates) in accordance with the Commercialization Schedules. If an Option is exercised for a Development Polypeptide, the Development Polypeptide and Development Pool Candidates [***] such Development Polypeptide will cease to be
in the Development Pool, but the applicable Research Target will not become a Discontinued Target. AstraZeneca will not have the right to Commercialize a Product Candidate or any other mRNA Construct for a Polypeptide under any of the Transaction
Agreements unless and until AstraZeneca has (x) properly provided an AstraZeneca Option Notice in the proper form identifying a Collaboration mRNA Construct [***] such Polypeptide, and (y) properly paid Moderna the Initial Payment with
respect to such Product Candidate. 
 (b)    Prior to selection of a Product Candidate for the AstraZeneca Oncology
Target, the Parties will negotiate in good faith on reaching agreement and will update this A&R Option Agreement to address the following: 

(i)    For those Products [***] a Polypeptide for the AstraZeneca Oncology Target, the Contingent Event Option Exercise
Payments in Paragraph 2.2 of Schedule A as of the Signing Date assume that [***]. Consequently, for those Products [***] a Polypeptide for the AstraZeneca Oncology Target that will not be [***]: 

(A)    [***] 

(B)    [***] 

(C)    [***] 

  
 20 

 A&R OPTION AGREEMENT 

 

 6.9    [***] Internal Revenue Code of 1986, as amended (the
“Code”) [***] 
 6.10    Option Termination on [***] Anniversary. Notwithstanding anything in
any of the Transaction Agreements to the contrary, all unexercised Options, and the right to exercise any and all Options if not previously exercised, will automatically terminate on the [***] anniversary of the Implementation Date. 

 

	7.	 Tax Matters. 

7.1    [***] 

7.2    [***] 

7.3    Indirect Taxes. Notwithstanding anything to the contrary contained in Section 7.2 or elsewhere in this
A&R Option Agreement, the following will apply with respect to Indirect Taxes. All payments hereunder are exclusive of Indirect Taxes. If any Indirect Taxes are chargeable in respect of any such payments, AstraZeneca will pay such Indirect Taxes
at the applicable rate in respect of any such payments following the receipt, where applicable, of an Indirect Taxes invoice issued by Moderna in respect of those payments, such Indirect Taxes to be payable on the due date of the payment of the
payments to which such Indirect Taxes relate or at the time such Indirect Taxes are required to be collected by Moderna, in the case of payment of Indirect Taxes to Moderna. The Parties will issue invoices for all goods and services supplied under
this A&R Option Agreement consistent with Indirect Tax requirements, and to the extent any invoice is not initially issued in an appropriate form, AstraZeneca will promptly inform Moderna and will cooperate with Moderna to provide such
information or assistance as may be necessary to enable the issuance of such invoice consistent with Indirect Tax requirements. 
  

	8.	 Regulatory Responsibilities. 

8.1    In General. As set forth in greater detail below in this Section 8, AstraZeneca will lead and have sole
control of all regulatory efforts for Collaboration mRNA Constructs, Product Candidates, and Products worldwide, including with respect to preparing and filing the relevant Regulatory Filings and all communications with Regulatory Authorities. 

8.2    Regulatory Filings . AstraZeneca will be responsible for preparing and submitting all Regulatory Filings
related to Collaboration mRNA Constructs, Product Candidates, and Products, including all applications for Regulatory Approval. All applications for Regulatory Approval, the Regulatory Approvals, and other Regulatory Filings (including all INDs)
relating to Collaboration mRNA Constructs, Product Candidates, and Products will be the property of AstraZeneca and held in the name of AstraZeneca or its designees. 

8.3    Interactions with Regulatory Authorities.    AstraZeneca will have the sole right to
conduct all communications with the Regulatory Authorities, including all meetings, conferences and discussions (including advisory committee meetings), with regard to Collaboration mRNA Constructs, Product Candidates, and Products in the Territory.

  
 21 

 A&R OPTION AGREEMENT 

 

 8.4    Moderna Regulatory Responsibilities Related to Manufacture.
Consistent with the provisions of Section 4.10 of the A&R Services and Collaboration Agreement, Moderna will, at its sole cost and expense, obtain and maintain all approvals, licenses, registrations, or authorizations (other than the
Regulatory Approval for a Product) that are necessary or useful in connection with the Manufacture of Collaboration mRNA Constructs, Product Candidates, and Products by or on behalf of Moderna. In addition, [***], Moderna will, when and as requested
by AstraZeneca, prepare the Chemistry, Manufacturing, and Controls (“CMC”) and other Manufacturing provisions with respect to all Regulatory Filings for, or that are otherwise necessary to obtain and maintain, Regulatory Approvals
for the Products, including with respect to any Manufacture and supply of Collaboration mRNA Constructs, Product Candidates, and Products by or on behalf of Moderna pursuant to Section 4 of the A&R Services and Collaboration Agreement,
including any amendments with respect thereto as AstraZeneca may request from time to time. As set forth in greater detail in Section 4.10 of the A&R Services and Collaboration Agreement, the CMC section of a Regulatory Approval for a
Product may reference Moderna’s DMF for such Product. 
  

	9.	 Intellectual Property. 

The Parties acknowledge and agree that the provisions of Section 2.5 of the A&R Services and Collaboration Agreement will govern the ownership of
Patents, Know-How and other intellectual property generated by or on behalf of a Party under or in connection with this A&R Option Agreement. 

 

	10.	 Patent Prosecution, Maintenance, Enforcement and Defense.  

10.1    Joint Patent Committee. 

(a)    As soon as practicable (but not later than [***] days) following the Implementation Date, the Parties will establish
a joint patent committee (the “Joint Patent Committee” or “JPC”), comprised of an equal number of members from each Party of which (i) at least one member from each Party will have experience in the
prosecution, enforcement and defense of intellectual property rights in the biopharmaceutical field, and (ii) one or members may be consultants or counsel to a Party. The JPC will serve as the primary contact and forum for discussion between
the Parties with respect to the [***] Collaboration Technology and have the particular responsibilities set forth in this Section 10 (“IP Matters”). Without limitation, the JPC will: 

(i)    (A) oversee and coordinate the Prosecution and Maintenance of [***]; (B) facilitate the extension of
[***]; (C) facilitate the listing of [***]; and (D) facilitate and coordinate [***]; 
 (ii)    determine
whether [***]; for clarity, it is understand and agreed that [***]; 
 (iii)    seek to resolve disputes between the
Parties regarding [***]; 

  
 22 

 A&R OPTION AGREEMENT 

 

 (iv)    implement procedures in order to comply with applicable Law in
any country in the Territory with respect to actions taken by the Parties with respect to Biosimilar Applications under Section 10.5, including procedures necessary to comply with more rigorous timing requirements than those set forth in
Section 10.5(b)(ii); 
 (v)    consider ownership and Prosecution and Maintenance of jointly owned Collaboration
Technology; 
 (vi)    keep the JSC reasonably informed of all material matters relating to IP Matters; and 

(vii)    [***]. 

(b)    The JPC will meet as often as agreed by them (and at least [***]) to enable the Parties to carry out their rights
and obligations under this Section 10.1. The JPC will determine by unanimous consent the JPC operating procedures at its first meeting, including the JPC’s policies for replacement of JPC members, and the location of meetings. Such
procedures will be recorded in the written minutes of the first JPC meeting and will be updated as agreed by the JPC. 

(c)    The JPC members will use reasonable efforts to reach agreement on all IP Matters, but if a matter within the
jurisdiction of the JPC cannot be reached by the JPC within [***] after the JPC first considers such matter (or such shorter period as may be reasonable in the circumstances), then, upon the written request of a Party, such matter will be referred
to the Executive Officers (or their designees, which designee is required to have decision-making authority on behalf of such Party), who will attempt in good faith to resolve such dispute by negotiation and consultation for a [***] period following
receipt of such written notice. If, despite such efforts, agreement on a particular matter cannot be reached by the Executive Officers within such [***] period, the matter will be resolved pursuant to [***]. 

(d)    With respect to any IP Matter not resolved pursuant to Section 10.1(c), either Party may elect to have such
dispute be finally settled by [***]. 
 10.2    Prosecution and Maintenance. 

(a)    Moderna General Background Patents. 

(i)    Moderna will have the sole right, but not the obligation, in consultation with the JPC and using counsel of its
choosing, to Prosecute and Maintain all Moderna General Background Patents throughout the Territory. 
 (ii)    [***]

 (iii)    Moderna will be solely responsible for the Patent Costs incurred by Moderna in connection with this
Section 10.2(a). 

  
 23 

 A&R OPTION AGREEMENT 

 

 (b)    [***] 

(i)    [***] 

(ii)    [***] 

(iii)    [***] 

(c)    [***] 

(i)    [***] 

(ii)    [***] 

(iii)    [***] 

(iv)    [***] 

(d)    [***] 

(i)    [***] 

(ii)    [***] 

(iii)    [***] 

(e)    [***] 

(i)    [***] 

(ii)    [***] 

(iii)    [***] 

(f)    [***] 

(i)    [***] 

(ii)    [***] 

(iii)    [***] 

(g)    [***] 

(h)    [***] 

  
 24 

 A&R OPTION AGREEMENT 

 

 10.3    Patent Extensions. With respect to any election for patent
term restoration or extension, supplemental protection certificate or any of their equivalents, (a) AstraZeneca will have the sole right to make any such decision relating to the [***]; (b) Moderna will have the right to make any such
decision relating to the [***] and (c) AstraZeneca will have the right to make any such decision relating to the [***]. Upon the request by a Party, such other Party through the JPC will reasonably cooperate in the implementation of such
requesting Party’s decisions under this Section 10.3. 
 10.4    Patent Listings. With respect to any
filings made to Regulatory Authorities with respect to the [***] for any Product, including as required or allowed in connection with in the United States, the FDA’s Orange Book, if applicable, or outside the United States, other international
equivalents: (a) AstraZeneca will have the sole right to make all decisions regarding such filings relating to the [***]; and (b) each Party may make such listings regarding any [***] as each Party deems is appropriate. Upon the request by
a Party, such other Party will reasonably cooperate in the implementation of such requesting Party’s decisions regarding the filing and listing of [***] pursuant to this Section 10.4. 

10.5    Enforcement and Defense. 

(a)    Notice. Each Party will promptly notify, in writing, the other Party through the JPC upon learning of any
actual or suspected Competitive Infringement by a Third Party, [***], and will, along with such notice, supply Moderna with any evidence in its possession pertaining thereto, and, subject to the terms of this Section 10.5, the JPC will discuss
in good faith strategies for abating such Competitive Infringement. 
 (b)    Enforcement. 

(i)    As between the Parties, [***]. 

(ii)    If either Party receives a copy of a Biosimilar Application naming a Product as a reference product or otherwise
becomes aware that such a Biosimilar Application has been filed (such as in an instance described in Section 351(1)(9)(C) of the PHSA), if the Exploitation of such Product as described in such Biosimilar Application would amount to Competitive
Infringement, the remainder of this Section 10.5(b)(ii) will apply; otherwise, Section 10.5(b)(iv) will apply. [***] Such Party will, within [***], notify the other Party through the JPC. Moderna will then seek permission to view the
application and related confidential information from the filer of the Biosimilar Application under Section 351(l)(1)(B)(iii) of the PHSA. If either Party receives any equivalent or similar certification or notice in the United States or any
other jurisdiction, either Party will, within [***], notify and provide the other Party through the JPC copies of such communication. Regardless of the Party that is the “reference product sponsor” for purposes of such Biosimilar
Application: 
 (A)    [***] 

(B)    [***] 

(C)    [***] 

(D)    [***] 

(E)    [***] 

  
 25 

 A&R OPTION AGREEMENT 

 

 (iii)    The Parties recognize that procedures other than those set
forth above in Section 10.5(b)(ii) may be applicable to Biosimilar Applications that are not governed by the PHSA. As a result, in the event that the JPC determines that certain provisions of Law in the United States or in any other country in
the Territory are applicable to actions taken by the Parties with respect to Biosimilar Applications under Section 10.5(b)(ii) in such country, the Parties will comply with any such applicable Law in such country (and any relevant and
reasonable procedures established by the JPC) in exercising their rights and obligations with respect to Biosimilar Applications under Section 10.5(b)(ii). 

(iv)    For that Competitive Infringement that is field limited per the definition thereof, if [***] is not [***] then
[***]. 
 (c)    Defense. As between the Parties, [***]. 

(d)    Withdrawal, Cooperation and Participation. With respect to any infringement or defensive action identified
above in this Section 10.5 and subject to the terms of this Section 10.5: 
 (i)    If the controlling Party
ceases to pursue or withdraws from such action, it will promptly notify the other Party through the JPC (in sufficient time to enable the other Party to meet any deadlines by which any action must be taken to preserve any rights in such infringement
or defensive action (including any such period of time as is required to comply with the provisions of Section 10.5(b)(ii)) and such other Party may substitute itself for the withdrawing Party and proceed under the terms and conditions of this
Section 10.5. 
 (ii)    The non-controlling Party will cooperate with the
Party controlling any such action (as may be reasonably requested by the controlling Party), including [***]. The Party controlling any such action will keep the other Party updated with respect to any such action, including providing copies of all
documents received or filed in connection with any such action. 
 (iii)    Each Party will have the right to
participate or otherwise be involved in any such action controlled by the other Party, in each case at the participating Party’s sole cost and expense and by counsel of its choosing. If a Party elects to so participate or be involved, the
controlling Party will provide the participating Party and its counsel with an opportunity to consult with the controlling Party and its counsel regarding the prosecution of such action (including reviewing the contents of any correspondence, legal
papers or other documents related thereto), and the controlling Party will take into account reasonable requests of the participating Party regarding such enforcement or defense. 

(e)    Settlement. With respect to any infringement or defensive action identified above in this Section 10.5,
the Party controlling such action will have the right to settle or otherwise dispose of such action on such terms as such Party will determine in its sole discretion, including, [***]; provided that, notwithstanding the foregoing, no such
settlement or other disposition will (i) impose any restriction or obligation on or admit fault of the other Party and (ii) adversely affect the scope, validity or enforcement of any [***], in each case ((i) and (ii) without the prior
written consent of the other Party (such consent not to be unreasonably withheld, delayed or conditioned). 

  
 26 

 A&R OPTION AGREEMENT 

 

 (f)    Damages. Unless otherwise agreed by the Parties, all monies
recovered upon the final judgment or settlement of any action described in Section 10.5(b) or any action described in Section 10.5(c) will be used first to reimburse each of the Parties on a pro rata basis for each of their out-of-pocket costs and expenses relating to the action, with the balance of any such recovery to be divided as follows: 

(i)    To the extent such recovery reflects [***]; 

(ii)    To the extent such recovery reflects [***]; and 

(iii)    For the remainder of any such recovery, [***]. 

10.6    Third Party Rights. Notwithstanding the foregoing provisions of this Section 10, each Party’s
rights and obligations with respect to the [***] will be subject to the Third Party rights and obligations under any Third Party agreements under which either Party enters into pursuant to Section 2.6 of the A&R Services &
Collaboration Agreement or is otherwise applicable to the [***]; provided, however, that, [***]. 

10.7    [***] 
  

	11.	 Confidentiality. 

The Parties acknowledge and agree that terms of this A&R Option Agreement and all Confidential Information transferred, disclosed or made available by a
Disclosing Party to a Receiving Party (or behalf of the Receiving Party to its Affiliates or a Third Party) under this A&R Option Agreement will be subject to the provisions of Section 7 of the A&R Services and Collaboration Agreement.

  

	12.	 Representations and Warranties; Covenants; Limitations of Liability; Indemnification. 

 12.1    Representations and Warranties of Each Party. Each Party represents, warrants and
covenants to the other as of the Signing Date and the Amendment Effective Date that: 
 (a)    Such Party is duly
organized, validly existing and in good standing under the laws of the jurisdiction in which it is organized. 

(b)    Such Party (i) has the legal right and power to enter into this A&R Option Agreement, to extend the rights
granted or to be granted to the other in this A&R Option Agreement, and to fully perform its obligations hereunder, and (ii) has taken all requisite action on its part to authorize the execution and delivery of this A&R Option Agreement
and the performance of its obligations hereunder. This A&R Option Agreement has been duly executed and delivered on behalf of such Party, and constitutes a legal, valid and binding obligation, enforceable against such Party in accordance with
its terms, except as may be limited by bankruptcy, insolvency, reorganization or other laws affecting creditors’ rights generally and by general equitable principles. 

  
 27 

 A&R OPTION AGREEMENT 

 

 (c)    Neither such Party nor its Affiliates has been debarred or is
subject to debarment. Neither it nor its Affiliates will use in any capacity, in connection with the services to be performed under the Transaction Agreements, any person who has been debarred pursuant to Section 306 of the FFDCA, or who is the
subject of a conviction described in such section. In addition, neither it nor its Affiliates has used in any capacity, in connection with any Development activities with respect to the mRNA Technology or any Polypeptide carried out prior to the
Signing Date, any person who has been debarred or was the subject of a conviction described in Section 306. Such Party agrees to inform the other Party in writing immediately if it or any person who is performing services under the Transaction
Agreements is debarred or is the subject of a conviction described in Section 306, or if any action, suit, claim, investigation or legal or administrative proceeding is pending or, to the best of such Party’s or its Affiliates’
Knowledge, is threatened, relating to the debarment or conviction of such Party or any person performing services under the Transaction Agreements, or if such Party becomes aware that it or any person performing Development activities with respect
to an mRNA Construct, Polypeptide, Product Candidate or Product carried out prior to the Signing Date was debarred or was the subject of a conviction described in Section 306. 

(d)    All necessary consents, approvals and authorizations of all governmental authorities and other Persons required to
be obtained by such Party to enter into, or perform its obligations under, this A&R Option Agreement have been obtained. 

(e)    The execution and delivery of this A&R Option Agreement and the performance of such Party’s obligations
hereunder (i) will not conflict with or violate any requirement of applicable Law or orders of governmental bodies except as individually or in the aggregate would not be reasonably expected to have a material adverse effect on or a material
adverse change in the ability of such Party to perform its obligations under or with respect to this A&R Option Agreement, and (ii) do not conflict with, or constitute a default under, any contractual obligation of such Party, except as
individually or in the aggregate would not have a material adverse effect on or a material adverse change in the ability of such Party to perform its obligations under or with respect to this A&R Option Agreement. 

(f)    Each Party covenants to the other Party that it will conduct its business in the ordinary course, consistent with
past practices, during the period from the Signing Date until the Implementation Date. Each Party covenants to the other Party that it will use its reasonable efforts to ensure that its representations and warranties set forth in this
Section 12.1 remain true and correct at and as of the Implementation Date as if such representations and warranties were made at and as of the Signing Date. 

12.2    Representations and Warranties of Moderna. Moderna hereby represents, warrants and covenants to AstraZeneca
as follows: 
 (a)    All Patents which are owned or in which Moderna has an ownership interest existing as of the
Signing Date (the “Existing Patents”) are listed on Schedule 1.101 of the A&R Services and Collaboration Agreement and all Existing Patents are owned solely or jointly by Moderna and are Controlled to
the extent owned by Moderna; Existing Patents that are jointly owned are marked on such Schedule. 

  
 28 

 A&R OPTION AGREEMENT 

 

 (b)    Moderna is the sole and exclusive owner of, or is solely and
exclusively licensed to, the entire right, title and interest in all the Know-How (other than (i) [***], (ii) [***], and (iii) [***]) used by Moderna in connection with the Exploitation of mRNA
Constructs as of the Signing Date (the “Existing Know-How”), and all Existing Know-How is Controlled by Moderna. 

(c)    As of the Signing Date, Moderna is entitled to grant the rights and licenses set forth in the Transaction
Agreements. As of the Signing Date, the Existing Patents and the Existing Know-How are not subject to any encumbrance or lien or, or to the Knowledge of Moderna, claim of ownership by any Third Party. Neither
Moderna nor any of its Affiliates has before the Signing Date entered into any agreement, whether written or oral, with respect to, or otherwise assigned, transferred, licensed, conveyed, or otherwise encumbered its right, title, or interest in or
to [***], and it will not after the Signing Date enter into any such agreements, grant any such right, title, or interest to any Person that is in conflict with the rights and licenses granted to AstraZeneca under the Transaction Agreements. 

(d)    To the Knowledge of Moderna, (i) the Existing Patents are subsisting as of the Signing Date; and (ii) the
conception, development and reduction to practice of the Existing Know-How and the Existing Patents, in each case as of the Signing Date, [***]. 

(e)    The pending applications included in the Existing Patents are as of the Signing Date being diligently prosecuted in
good faith before the respective patent offices in accordance with applicable Law, and Moderna and its Affiliates have presented to the extent required as of the Signing Date all relevant references, documents and information of which it and the
inventors are aware to the respective patent offices. As of the Signing Date, the Existing Patents have been filed and maintained and all applicable fees have been paid on or before the due date for payment. [***] 

(f)    As of the Signing Date, to the Knowledge of Moderna, there is [***]. The trade secrets used by Moderna as of the
Signing Date has been kept confidential or has been disclosed to Third Parties only under terms of confidentiality and, to the Knowledge of Moderna and its Affiliates, no breach of such confidentiality has been committed by any Third Party. 

(g)    As of the Signing Date, no Third Party claim or litigation has been brought or threatened by any Person alleging
that (i) the Existing Patents or the Existing Know-How are invalid or unenforceable, or (ii) the conception, development, reduction to practice, disclosing, copying, making, assigning, or licensing
of the Existing Patents or the Existing Know-How, or the Exploitation of mRNA Constructs, Product Candidates or Products as contemplated in the Transaction Agreements, violates, infringes, constitutes
misappropriation or otherwise conflicts or interferes with, or would violate, infringe, or otherwise conflict or interfere with, any intellectual property or proprietary right of any Person. 

(h)    [***] 

(i)    All current and former officers, employees, agents and consultants of Moderna or any of its Affiliates who are
inventors of or have otherwise contributed in a material manner to the creation or development of any Existing Patent or Existing Know-How or who are or will be performing activities on behalf of Moderna
hereunder or who otherwise have access to any 

  
 29 

 A&R OPTION AGREEMENT 

 

 
Confidential Information of AstraZeneca have executed and delivered to Moderna an obligation to assign or an assignment of rights (or are bound [***]) to any and all Patents, Know-How or other information that relate to mRNA Constructs and are generated pursuant to and during the time of such person’s relationship with Moderna or its Affiliate, such that AstraZeneca will, by virtue
of the Transaction Agreements, receive from Moderna, without payments beyond those required by the Transaction Agreements, the licenses and other rights granted to AstraZeneca under the Transaction Agreements. To Moderna’s Knowledge, as of the
Signing Date, no current officer, employee, agent, or consultant of Moderna or any of its Affiliates is in violation of any term of any assignment or other agreement regarding the protection of Patents or other intellectual property or proprietary
information of Moderna or such Affiliate or of any employment contract or any other contractual obligation relating to the relationship of any such Person with Moderna. 

(j)    The inventions claimed or covered by the Existing Patents (i) were not discovered, developed, or otherwise
made in connection with any research activities funded, in whole or in part, by [***], and (ii) [***], and (c) are not [***]. 

(k)    There are no license agreements or other agreements as of the Signing Date pursuant to which Moderna is
sublicensing the [***] to AstraZeneca. 
 (l)    As of the Signing Date, neither Moderna nor any of its Affiliates, nor
any of its or their respective officers, employees, consultants or agents has made an untrue statement of material fact or fraudulent statement to the FDA or any other Regulatory Authority with respect to the mRNA Technology or the Development of
mRNA Constructs, failed to disclose a material fact required to be disclosed to the FDA or any other Regulatory Authority with respect to the mRNA Technology or the Development of mRNA Constructs. 

(m)    [***] 

12.3    Moderna Corporate Covenants. 

(a)    [***] 

(b)    [***] 

(c)    [***] 

(d)    This Section 12.3 will terminate, and be of no further force or effect (a) immediately before the
consummation of Moderna’s (or its Affiliate’s) first underwritten public offering of its Common Stock under the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder, (b) when Moderna first becomes
subject to the periodic reporting requirements of Section 12(g) or 15(d) of the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder, or (c) immediately before a Business Combination of Moderna.

 12.4    Disclaimers. Without limiting the respective rights and obligations of the Parties expressly set forth
herein, each Party specifically disclaims any guarantee that an Optioned Product Candidate will be successful, in whole or in part. EXCEPT AS OTHERWISE EXPRESSLY 

  
 30 

 A&R OPTION AGREEMENT 

 

 
PROVIDED IN THIS A&R OPTION AGREEMENT, THE PARTIES MAKE NO REPRESENTATIONS AND EXTEND NO WARRANTY OF ANY KIND, EITHER EXPRESS OR IMPLIED, WITH RESPECT TO ANY MODERNA TECHNOLOGY, PRODUCT
CANDIDATES, OR MATERIALS, INCLUDING WARRANTIES OF VALIDITY OR ENFORCEABILITY OF ANY PATENTS, TITLE, QUALITY, MERCHANTABILITY, FITNESS FOR A PARTICULAR USE OR PURPOSE, PERFORMANCE, AND NONINFRINGEMENT OF ANY THIRD PARTY PATENTS OR OTHER INTELLECTUAL
PROPERTY RIGHTS. 
 12.5    No Consequential Damages. NOTWITHSTANDING ANYTHING IN THIS A&R OPTION AGREEMENT,
EXCEPT FOR DAMAGES DUE TO THE FRAUD OR WILLFUL MISCONDUCT OF THE LIABLE PARTY, NEITHER PARTY WILL BE LIABLE TO THE OTHER OR ANY THIRD PARTY WITH RESPECT TO ANY SUBJECT MATTER OF THIS A&R OPTION AGREEMENT FOR ANY INDIRECT, PUNITIVE, SPECIAL OR
CONSEQUENTIAL DAMAGES, EVEN IF SUCH PARTY HAS BEEN INFORMED OR SHOULD HAVE KNOWN OF THE POSSIBILITY OF SUCH DAMAGES; PROVIDED THAT THIS SECTION 12.5 WILL NOT APPLY TO THE PARTIES’ INDEMNIFICATION RIGHTS AND OBLIGATIONS UNDER THE A&R
SERVICES AND COLLABORATION AGREEMENT. 
 12.6    Indemnification. 

(a)    Indemnification by AstraZeneca. AstraZeneca will indemnify Moderna, its Affiliates and their respective
directors, officers, employees, Third Party licensors under the Existing In-License Agreements and agents, and their respective successors, heirs and assigns (collectively, “Moderna
Indemnitees”), and defend and save each of them harmless, from and against any and all losses, damages, liabilities, costs and expenses (including reasonable attorneys’ fees and expenses) (collectively, “Losses”) in
connection with any and all suits, investigations, claims or demands of Third Parties (collectively, “Third Party Claims”) arising from or occurring as a result of: [***], except in each case for those Losses for which Moderna
has an obligation to indemnify AstraZeneca pursuant to Section 12.6(b), the A&R Services and Collaboration Agreement or the Original Agreements (or would have had such Third Party Claim been made against AstraZeneca), as to which Losses
each Party will indemnify the other to the extent of their respective liability; provided, however, that AstraZeneca will not be obligated to indemnify Moderna Indemnitees for any Losses to the extent that such Losses arise as a result of
gross negligence or willful misconduct on the part of a Moderna Indemnitee. 
 (b)    Indemnification by Moderna.
Moderna will indemnify AstraZeneca, its Affiliates and their respective directors, officers, employees and agents, and their respective successors, heirs and assigns (collectively, “AstraZeneca Indemnitees”), and defend and
save each of them harmless, from and against any and all Losses in connection with any and all Third Party Claims arising from or occurring as a result of: [***], except in each case for those Losses for which AstraZeneca has an obligation to
indemnify Moderna pursuant to Section 12.6(a), the A&R Services and Collaboration Agreement or the Original Agreements (or would have had such Third Party Claim been made against Moderna), as to which Losses each Party will indemnify the
other to the extent of their respective liability for the Losses; provided, however, that Moderna will not 

  
 31 

 A&R OPTION AGREEMENT 

 

 
be obligated to indemnify AstraZeneca Indemnitees for any Losses to the extent that such Losses arise as a result of (1) gross negligence or willful misconduct on the part of an AstraZeneca
Indemnitee or (2) [***]. 
 (c)    Notice of Claim. All indemnification claims provided for in
Section 12.6(a) and 12.6(b) will be made solely by such Party to this A&R Option Agreement (the “Indemnified Party”). The Indemnified Party will promptly notify the indemnifying Party (an “Indemnification Claim
Notice”) of any Losses or the discovery of any fact upon which the Indemnified Party intends to base a request for indemnification under Section 12.6(a) or 12.6(b), but in no event will the indemnifying Party be liable for any Losses
that result from any delay in providing such notice. Each Indemnification Claim Notice must contain a description of the claim and the nature and estimated amount of such Loss (to the extent that the nature and amount of such Loss is known at such
time). The Indemnified Party will furnish promptly to the indemnifying Party copies of all papers and official documents received in respect of any Losses and Third Party Claims. 

(d)    Defense, Settlement, Cooperation and Expenses. 

(i)    Control of Defense. At its option, the indemnifying Party may assume the defense of any Third Party Claim by
giving written notice to the Indemnified Party within [***] days after the indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the indemnifying Party will not be construed as
an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor will it constitute a waiver by the indemnifying Party of any defenses it may assert against the Indemnified
Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party (the
indemnifying Party will consult with the Indemnified Party with respect to a possible conflict of interest of such counsel retained by the indemnifying Party). In the event the indemnifying Party assumes the defense of a Third Party Claim, the
Indemnified Party will immediately deliver to the indemnifying Party all original notices and documents (including court papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the
defense of a Third Party Claim, except as provided in Section 12.6(d)(ii), the indemnifying Party will not be liable to the Indemnified Party for any legal costs or expenses subsequently incurred by such Indemnified Party in connection with the
analysis, defense or settlement of the Third Party Claim. [***] 
 (ii)    Right to Participate in Defense.
Without limiting Section 12.6(d)(i), any Indemnified Party will be entitled to participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, however, that such employment
will be at the Indemnified Party’s own cost and expense unless [***]. 
 (iii)    Settlement. With respect
to any Third Party Claims that relate solely to the payment of money damages in connection with a Third Party Claim and that will not result in the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely
affecting the business of the Indemnified Party in any manner, and as to which the indemnifying Party will have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, the

  
 32 

 A&R OPTION AGREEMENT 

 

 
indemnifying Party will have the sole right to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its
sole discretion, will deem appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has assumed the defense of the Third Party Claim in accordance with Section 12.6(d)(i), the
indemnifying Party will have authority to agree to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss provided it obtains the prior written consent of the Indemnified Party (such consent not to be unreasonably
withheld, delayed or conditioned). The indemnifying Party will not be liable for any settlement or other disposition of a Loss by an Indemnified Party that is reached without the prior written consent of the indemnifying Party. Regardless of whether
the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party will admit any liability with respect to or settle, compromise or discharge, any Third Party Claim without the prior written consent of the
indemnifying Party, such consent not to be unreasonably withheld, delayed or conditioned. 

(iv)    Cooperation. If the indemnifying Party chooses to defend or prosecute any Third Party Claim, the
Indemnified Party will, and will cause each other Indemnified Party to, cooperate in the defense or prosecution thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery
proceedings, hearings, trials and appeals as may be reasonably requested in connection therewith. Such cooperation will include access during normal business hours afforded to indemnifying Party to, and reasonable retention by the Indemnified Party
of, records and information that are reasonably relevant to such Third Party Claim, and making Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any
material provided hereunder, and the indemnifying Party will reimburse the Indemnified Party for all its reasonable out-of-pocket costs and expenses in connection
therewith. 
 (v)    Costs and Expenses. Except as provided above in this Section 12.6(d), the reasonable
and verifiable costs and expenses, including attorneys’ fees and expenses, incurred by the Indemnified Party in connection with any claim will be reimbursed on a Calendar Quarter basis by the indemnifying Party, without prejudice to the
indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 

 

	13.	 Term and Termination. 

13.1    Option Agreement Term. This A&R Option Agreement will commence as of the Amendment Effective Date and on
such date will replace and supersede the Original Option Agreement in its entirety; provided that [***]. The term of this A&R Option Agreement, unless sooner terminated in accordance with the terms hereof or by mutual written consent, will be
deemed to have commenced on the Signing Date and will continue until the entire Exercise Price for each Optioned Product Candidate (and associated Development Pool Candidates) is paid in full (the “Option Agreement Term”). 

13.2    Termination by Moderna. Moderna will have the right to terminate this A&R Option Agreement in full upon
delivery of written notice to AstraZeneca in the event of any material breach by AstraZeneca of any terms and conditions of this A&R Option Agreement [***], 

  
 33 

 A&R OPTION AGREEMENT 

 

 
provided, that to the extent that any such breach is limited to Collaboration mRNA Constructs [***] a particular Research Polypeptide or Development Polypeptide, Moderna will have the
right to terminate this A&R Option Agreement only with respect to such Collaboration mRNA Constructs, and (a) such Collaboration mRNA Constructs will become Discontinued Product Candidates, (b) the Polypeptide [***] such Collaboration
mRNA Constructs will become a Discontinued Polypeptide and (c) the Research Target [***] such Discontinued Polypeptide will become a Discontinued Research Target unless for such Research Target there is an Optioned Product Candidate [***] a
Development Polypeptide for such Research Target. For clarity, for the purposes of such discontinuance, [***]. Notwithstanding the foregoing, any such termination under this Section 13.2 will not be effective if such breach has been cured
within [***] days after written notice thereof is given by Moderna to AstraZeneca specifying the nature of the alleged breach (or, if such default cannot be cured within such [***]-day period, such longer
period as reasonably required to cure such breach, provided that AstraZeneca commences actions to cure such default within such [***]-day period and thereafter diligently continues such actions); provided,
that to the extent such material breach involves the failure to make an undisputed payment when due, such breach must be cured within [***] days after written notice thereof is given by Moderna to AstraZeneca. [***] 

13.3    Termination by AstraZeneca. 

(a)    Breach. AstraZeneca will have the right to terminate this A&R Option Agreement in full upon delivery of
written notice to Moderna in the event of any material breach by Moderna of any terms and conditions of this A&R Option Agreement [***], provided, that to the extent that any such breach is limited to a particular Polypeptide (and
Collaboration mRNA Constructs [***] such Polypeptide), AstraZeneca will have the right to terminate this A&R Option Agreement only with respect to such Polypeptide (and Collaboration mRNA Constructs [***] such Polypeptide). Notwithstanding the
foregoing, any such termination under this Section 13.3(a) will not be effective if such breach has been cured within [***] days after written notice thereof is given by AstraZeneca to Moderna specifying the nature of the alleged breach (or, if
such default cannot be cured within such [***]-day period, such longer period as reasonably required to cure such breach, provided that Moderna commences actions to cure such default within such [***] period
and thereafter diligently continues such actions); provided, that to the extent such material breach involves the failure to make an undisputed payment when due, such breach must be cured within [***] days after written notice thereof is
given by AstraZeneca to Moderna. [***] 
 (b)    Discretionary Termination. AstraZeneca will have the right to
terminate this A&R Option Agreement in full ninety (90) days after delivery of written notice to Moderna if the Executive Officer of AstraZeneca concludes due to scientific, technical, regulatory or commercial reasons, including [***]. 

13.4    Alternative to Termination Under Section 13.3(a). If AstraZeneca has the right to
terminate this A&R Option Agreement or this A&R Option Agreement with respect to a particular Polypeptide that is [***] an Optioned Product Candidate (or Subject Construct or Product) under Section 13.3(a) (including expiration of all
applicable cure periods thereunder), in lieu of exercising such termination right, AstraZeneca may elect once by written notice to Moderna before the end of such applicable cure period to have this A&R Option Agreement continue in full force and
effect, in which case the following will apply: 

  
 34 

 A&R OPTION AGREEMENT 

 

 (a)    Starting immediately after the end of such applicable cure period,
any payments for Contingent Event Option Exercise Payment and Option Exercise Earn-Out payments hereunder payable following such date that AstraZeneca has the right to terminate this A&R Option Agreement
under Section 13.3(a) will be reduced by [***], provided that such reduction will not apply if and to the extent [***]; provided that if such right of termination is limited to a particular Optioned Product, Subject Construct or Product,
then such [***] reduction will apply to such Optioned Product Candidate, Subject Construct or Product and will not apply more generally. 

(b)    The following provisions will cease to apply: [***] of the Product Commercialization Schedule; provided that [***].

 13.5    Effects of Termination or Expiration. Upon termination or expiration of this A&R Option Agreement
for any reason: 
 (a)    The license grants (including Section 3.1) will terminate, other than [***]; 

(b)    Any unpaid Exercise Price attributable to those Optioned Product Candidate (and associated Development Pool
Candidates) will remain due and payable to Moderna, pursuant to the applicable Schedule A; and 

(c)    All unexercised Options will automatically terminate; 

Provided that, in the event that either Party terminates this A&R Option Agreement with respect to a particular Optioned Product Candidate, Subject
Construct or Product, the provisions of Section 6.3 of the Product Commercialization Schedule will apply. 

13.6    Survival. In addition to the termination consequences set forth in Section 13.5, the following
provisions will survive termination or expiration of this A&R Option Agreement: [***]. Termination or expiration of this A&R Option Agreement will not relieve the Parties of any liability or obligation which accrued hereunder prior to the
effective date of such termination or expiration nor preclude either Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this A&R Option Agreement nor prejudice either
Party’s right to obtain performance of any obligation. All other rights and obligations will terminate upon expiration of this A&R Option Agreement. 

13.7    Integrated Agreements. The Parties acknowledge that the Transaction Agreements, together, constitute an
integrated set of agreements entered into as part of the same transaction that collectively govern the subject matter covered by the Transaction Agreements. Early termination of any one of the Transaction Agreements without the others would
fundamentally alter the intended allocation of rights and obligations intended by the Parties in entering into the Transaction Agreements. Thus, if a Party (or its bankruptcy trustee) has the right to reject any of the Transaction Agreements under
the U.S. Bankruptcy Code or any analogous provision under any other law in any country outside the United States, such Party (or the applicable bankruptcy trustee) will either reject all of the Transaction Agreements or assume all of the Transaction
Agreements, but may not reject one Transaction Agreement without rejecting the others. 

  
 35 

 A&R OPTION AGREEMENT 

 

	14.	 General Provisions. 

14.1    Dispute Resolution. Disputes arising under or in connection with this A&R Option Agreement will be
resolved in accordance with Section 11.1 of the A&R Services and Collaboration Agreement. 

14.2    Cumulative Remedies and Irreparable Harm. All rights and remedies of the Parties hereunder will be
cumulative and in addition to all other rights and remedies provided hereunder or available by agreement, at law or otherwise. Each Party acknowledges and agrees that breach of any of the terms or conditions of this A&R Option Agreement would
cause irreparable harm and damage to the other and that such damage may not be ascertainable in money damages and that as a result thereof the non-breaching Party would be entitled to seek on an interim basis
from a court and on a permanent basis from an arbitral tribunal equitable or injunctive relief restraining any breach or future violation of the terms contained herein by the breaching Party without the necessity of proving actual damages or posting
bond. Such right to equitable relief is in addition to whatever remedies either Party may be entitled to as a matter of law or equity, including money damages. 

14.3    Business Combination and Exclusivity. The Parties acknowledge and agree that the provisions of 11.3 of the
A&R Services and Collaboration Agreement will govern the Parties rights and obligations with respect to a Business Combination under this A&R Option Agreement. 

14.4    Relationship of Parties. Nothing in this A&R Option Agreement is intended or will be deemed to
constitute a partnership, agency, employer-employee or joint venture relationship between the Parties. No Party will incur any debts or make any commitments for the other, except to the extent, if at all, specifically provided therein. There are no
express or implied third party beneficiaries hereunder. 
 14.5    Anti-Bribery and Corruption Compliance. The
Parties acknowledge and agree that the provisions of Section 11.4 of the A&R Services and Collaboration Agreement will govern anti-bribery and corruption compliance under this A&R Option Agreement. 

14.6    Compliance with Law. Each Party will perform or cause to be performed any and all of its obligations or the
exercise of any and all of its rights hereunder in good scientific manner and in compliance with all applicable Law. 

14.7    Governing Law. This A&R Option Agreement will be governed by and construed in accordance with the Laws
of the state of New York, without respect to its conflict of laws rules or principles that might otherwise refer construction or interpretation of this A&R Option Agreement to the substantive Law of another jurisdiction; provided,
however, that any dispute relating to the scope, validity, enforceability or infringement of any Patents will be governed by, and construed and enforced in accordance with, the substantive Laws of the jurisdiction in which such Patents apply.
The Parties agree to exclude the application to this A&R Option Agreement of the United Nations Convention on Contracts for the International Sale of Goods. 

  
 36 

 A&R OPTION AGREEMENT 

 

 14.8    Counterparts; Facsimiles. This A&R Option Agreement
may be executed in one or more counterparts, each of which will be deemed an original, and all of which together will be deemed to be one and the same instrument. Facsimile or PDF execution and delivery of this A&R Option Agreement by either
Party will constitute a legal, valid and binding execution and delivery of this A&R Option Agreement by such Party. 

14.9    Headings. All headings in this A&R Option Agreement are for convenience only and will not affect the
meaning of any provision hereof. 
 14.10    Waiver of Rule of Construction. Each Party has had the opportunity
to consult with counsel in connection with the review, drafting and negotiation of this A&R Option Agreement. Accordingly, the rule of construction that any ambiguity in this A&R Option Agreement will be construed against the drafting party
will not apply. 
 14.11    Interpretation. Whenever any provision of this A&R Option Agreement uses the term
“including” (or “includes”), such term will be deemed to mean “including without limitation” (or “includes without limitations”). “Herein,” “hereby,” “hereunder,”
“hereof” and other equivalent words refer to this A&R Option Agreement as an entirety and not solely to the particular portion of this A&R Option Agreement in which any such word is used. Except where the context otherwise
requires, whenever used, the singular will include the plural, the plural the singular, the use of any gender will be applicable to all genders and the word “or” is used in the inclusive sense (and/or). Unless otherwise provided, all
references to Sections, Exhibits and Schedules in this A&R Option Agreement are to Sections, Exhibits and Schedules of this A&R Option Agreement. References to any Sections include Sections and subsections that are part of the related
Section (e.g., a section numbered “Section 2.1” would be part of “Section 2”, and references to “Section 2.1” would also refer to material contained in the subsection described
as “Section 2.1(a)”). 
 14.12    Binding Effect. This A&R Option Agreement will inure to
the benefit of and be binding upon the Parties, their Affiliates, and their respective lawful successors and assigns. 

14.13    Assignment. This A&R Option Agreement may not be assigned by either Party, nor may either Party
delegate its obligations or otherwise transfer any rights created by this A&R Option Agreement, except as expressly permitted hereunder or otherwise without the prior written consent of the other Party, which consent will not be unreasonably
withheld, delayed or conditioned; provided that either Party may assign this A&R Option Agreement to an Affiliate or to such Party’s successor in connection with the merger, consolidation, sale of all or substantially all of its
assets or that portion of its business pertaining to the subject matter of this A&R Option Agreement, or any Business Combination of such Party. Notwithstanding the foregoing, neither Party may assign this A&R Option Agreement unless such
assignment also includes an assignment of all of the Transaction Agreements to the same Affiliate or Third Party successor, as applicable. The rights and obligations of the Parties under this A&R Option Agreement will be binding upon and inure
to the benefit of the successors and permitted assigns of the Parties, and the name of a Party appearing herein will be deemed to include the name of such Party’s successors and permitted assigns to the extent necessary to carry out the intent
of this Section 14.13. 

  
 37 

 A&R OPTION AGREEMENT 

 

 14.14    Amendment and Waiver. This A&R Option Agreement may
be amended, supplemented, or otherwise modified only by means of a written instrument signed by both Parties; provided that any unilateral undertaking or waiver made by one Party in favor of the other will be enforceable if undertaken in a
writing signed by the Party to be charged with the undertaking or waiver. Any waiver of any rights or failure to act in a specific instance will relate only to such instance and will not be construed as an agreement to waive any rights or fail to
act in any other instance, whether or not similar. 
 14.15    Severability. In the event that any provision of
this A&R Option Agreement will, for any reason, be held to be invalid or unenforceable in any respect, and if the rights or obligations of either Party under this A&R Option Agreement will not be materially and adversely affected thereby,
(a) such provisions will be given no effect by the Parties and will not form part of this A&R Option Agreement, (b) all other provisions of this A&R Option Agreement will remain in full force and effect, and (c) the Parties
will negotiate in good faith to modify this A&R Option Agreement to preserve (to the extent possible) their original intent. 

14.16    Entire Agreement. This A&R Option Agreement, along with the other Transaction Agreements (and any
agreements entered into pursuant to the Original Agreements), are the sole agreements with respect to the subject matter hereof and except as provided in Section 13.1, supersedes all other agreements and understandings between the Parties with
respect to same (including the Confidentiality Agreement). 
 [Remainder of this Page Intentionally Left Blank] 

  
 38 

 A&R OPTION AGREEMENT 

 

 IN WITNESS WHEREOF, the Parties have caused this A&R Option Agreement to be executed by
their respective duly authorized officers as of the Amendment Effective Date. 
  

			
	MODERNATX, INC.
		
	By:	 	 /s/ Stéphane Bancel

		 	(Signature)
	Name:	 	 Stéphane Bancel

	Title:	 	 CEO

	Date:	 	 June 15, 2018

 A&R OPTION AGREEMENT 

 

			
	ASTRAZENECA AB
		
	By:	 	 /s/ Jesper Bergkvist

		 	(Signature)

			
	Name:	 	 Jesper Bergkvist

	Title:	 	 Legal Director

	Date:	 	 June 15, 2018

 A&R OPTION AGREEMENT 

Exhibit A 
 The
AstraZeneca CV Targets 
 [***] 
  

			
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

 A&R OPTION AGREEMENT 

Exhibit B 

The AstraZeneca Exclusive Target 

[***] 
  

			
	[***]	  	[***]

 A&R OPTION AGREEMENT 

Exhibit C 

The AstraZeneca Oncology Target 

[***] 
  

			
	[***]	  	[***]

 A&R OPTION AGREEMENT 

 

 Exhibit D 

Discontinued Targets as of the Amendment Effect Date 

Discontinued Targets (CV) 
  

			
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	
		
	[***]	  	
		
	[***]	  	
		
	[***]	  	
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

  
 1 

 A&R OPTION AGREEMENT 

 

 Discontinued Targets (Oncology) 

 

			
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

  
 2 

 A&R OPTION AGREEMENT 

 

 Schedule A 

Schedule of Exercise Price Payable for each Optioned Product Candidate 

for each Option Exercise 
 This
Schedule A will apply to each Optioned Product Candidate (and all associated Development Pool Candidates) on an Optioned Product Candidate-by-Optioned Product
Candidate and Product-by-Product basis in all respects. For each such Optioned Product Candidate, Development Pool Candidates and Products, the Product Commercialization
Schedule will also apply. 
 The following terms and their correlatives will have the meanings set forth below. Capitalized terms used, but not defined,
herein will have the meanings ascribed to such terms in the body of the Option Agreement and the other Transaction Agreements. 
  

	1.	 Definitions. 

1.1    “EU” means the organization of member states of the European Union as it may be constituted from
time to time. 
 1.2    “First Commercial Sale” means the first arm’s length sale by AstraZeneca,
its Affiliates, or its Sublicensees to a Third Party for end use or consumption by the general public of a Product in a country after all required Regulatory Approvals for commercial sale of such Product have been obtained by AstraZeneca, its
Affiliates or its Sublicensees in such country; provided, however, that in no event will any sale or distribution of such Product for use in clinical trial or otherwise any sales prior to receipt of all Regulatory Approvals necessary to
commence regular commercial sales (including so-called “treatment IND sales” and “compassionate use sales”) be deemed a First Commercial Sale. 

1.3    “Generic Product” means, with respect to a Product in a given country, any generic or biosimilar
product sold by a Third Party not licensed or otherwise authorized by or on behalf of AstraZeneca or any of its Affiliates or Sublicensees (a) that is a “biological product” (as defined in Section 351(i)(1) of the PHSA) that is
subject to a license for administration to humans under Section 351(a) or 351(k) of the PHSA and (i) contains an active ingredient that is the same as the active ingredient of such Product (including any mRNA Constructs therein) or
(ii) is “biosimilar” (as defined in Section 351(i)(2) of the PHSA) or “interchangeable” (as defined in Section 351(i)(3) of the PHSA) to the Product; or (b) that has received analogous Regulatory Approval from
the applicable Regulatory Authority by referencing Regulatory Filings (and data therein) of such Product. 

1.4    “Net Sales” means the gross invoiced amount on sales of a Product by AstraZeneca and its
Affiliates and its Sublicensees to Third Parties (which will include Distributors but not Sublicensees) after deduction of the following amounts: 

(a)    [***] 

(b)    [***] 

  
 1 

 A&R OPTION AGREEMENT 

 

 (c)    [***] 

(d)    [***] 

(e)    [***] 

(f)    [***] 

(g)    [***] 

(h)    [***] 

(i)    [***] 

(j)    [***] 
 In the event
that a Product is sold in any country in the form of a combination Product containing one or more therapeutically active ingredient(s), in addition to the applicable Optioned Product Candidate or any related Subject Constructs, (such product
containing such other active ingredient, if sold separately, the “Other Product”), Net Sales of such combination Product will be determined as follows: 
  

			
	[***]	  	[***]
		
	[***]	  	[***]
		
	[***]	  	[***]

 [***] 
 Net Sales will be
calculated using AstraZeneca’s internal audited systems used to report such sales as adjusted for any of items [***] above not taken into account in such systems. [***]. 

[***]. Sales and other transfer of Product between any of AstraZeneca, its Affiliates and Sublicensees will not give rise to Net Sales, but rather the
subsequent sale of Product to Third Parties. 
 1.5    “Phase 2 Study” means a clinical trial of a
Product the principal purpose of which is a determination of safety and an assessment of its efficacy in the target patient population as described under 21 C.F.R. §312.21(b) (as amended or any replacement thereof), or a similar clinical study
prescribed by the Regulatory Authorities in a foreign country. 
 1.6    “Phase 3 Study” means a
clinical trial of a Product on a sufficient number of subjects that is designed to establish that a Product is safe and efficacious for its intended use, and to determine warnings, precautions, and adverse reactions that are associated with such
Product in the dosage range to be prescribed, which trial is intended to support Regulatory Approval of such Product, as described in 21 C.F.R. 312.21(c) (as amended or any replacement thereof), or a similar clinical study prescribed by the
Regulatory Authorities in a foreign country. 

  
 2 

 A&R OPTION AGREEMENT 

 

 1.7    “PHSA” means the United States Public Health
Service Act, as amended. 
 1.8    “Selling Party” means AstraZeneca and its Affiliates and
Sublicensees (excluding Distributors). 
 1.9    “Valid Claim” means, with respect to a particular
country, [***]. 
  

	2.	 Exercise Price. 

2.1    Initial Payment. The Initial Payment is payable by AstraZeneca to Moderna pursuant to Section 6.5(b) of
the Option Agreement. 
 2.2    Contingent Event Option Exercise Payments. 

AstraZeneca will make a payment to Moderna upon the occurrence of each of the events (each, a “Contingent Event”) as set
forth below in this Paragraph 2.2 (Schedule A) (each such payment, a “Contingent Event Option Exercise Payment”). AstraZeneca will give Moderna written notice within [***] days of the first achievement of each Contingent Event
set forth below, whether achieved by or on behalf of AstraZeneca, its Affiliate, or Sublicensee. After receiving such written notice, Moderna will submit an invoice to AstraZeneca for the amount of the Contingent Event Option Exercise Payment, and
AstraZeneca will pay Moderna the applicable Contingent Event Option Exercise Payment within [***][***] days after AstraZeneca’s receipt of such invoice. [***][***] 
  

					
	 Contingent Event
	  	 Contingent Event Option Exercise
Payment

			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]

 2.3    Option Exercise Earn-Out Payments.

 (a)    Rates. Subject to the remainder of this Paragraph 2.3(a) (Schedule A), AstraZeneca will pay to
Moderna an earn-out (the “Option Exercise Earn-Out”), [***], based on the total aggregate annual worldwide Net Sales by Selling Parties of such
Product in a given calendar year at the following Option Exercise Earn-Out rates: 
  

					
	 Annual Worldwide Net Sales of each
Product
	  	 Earn Out Rate

			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	[***]
			
	[***]	  	[***]	  	Twelve Percent (12%)

  
 3 

 A&R OPTION AGREEMENT 

 

 Annual worldwide Net Sales will be calculated by taking the aggregate sum of Net Sales of Products for all
countries worldwide. 
 By way of example, in a given calendar year, if the aggregate annual worldwide Net Sales for a Product is [***], the following
Option Exercise Earn-Out payment would be payable for those Net Sales under this Paragraph 2.3(a) (Schedule A): [***]. 

(b)    Option Exercise Earn-Out Term. The Option Exercise Earn-Out under Paragraph 2.3(a) (Schedule A) will be payable, [***], on the Net Sales of such Product from the date of First Commercial Sale of such Product in such country for so long as at least one of the
following [***] conditions apply: 
 (i)    if one or more Valid Claims within [***]; 

(ii)    Such Product in such country is covered by a Regulatory Exclusivity Period; 

(iii)    [***] 

(iv)    for [***] from the First Commercial Sale of such Product in such country. 

(c)    Option Exercise Earn-Out Reductions. 

(i)    Option Exercise Earn-Out Reduction. If a Product used to treat
patients is subject to an Option Exercise Earn-Out payment only on account of [***], but not [***] or [***], then the Option Exercise Earn-Out rates set forth in
Paragraph 2.3(a) (Schedule A) with respect to Net Sales attributable to Product will be reduced by [***]. 

(ii)    Third-Party Payments. If, during the applicable Earn-Out Term,
AstraZeneca [***], then, upon [***], and thereafter during the remainder of the period during which AstraZeneca owes Option Exercise Earn-Out payments to Moderna hereunder, AstraZeneca will have the right to
deduct from the Option Exercise Earn-Out payments due to Moderna under Paragraph 2.3(a) (Schedule A) [***] of [***] (including [***]) by AstraZeneca to such Third Party; provided, however, that
in no event will the Option Exercise Earn-Out amounts payable to Moderna in a particular Calendar Quarter be reduced as a result of this Paragraph 2.3(c)(ii) (Schedule A) to a rate lower than [***]; and
provided, further, that [***]. 
 (iii)    Generic Product Competition. If, at any time, in a particular
country in the Territory, with respect to a Product being sold in such country, (i) a Generic Product of such Product is sold by any Third Party in such country and (ii)[***], then for the purposes of calculating the Earn-Own payment of such Product owed to Moderna under Paragraph 2.3(a) (Schedule A), [***] will be disregarded for such Calendar Quarter. The calculation of the reduction under this Paragraph 2.3(c)(iii) (Schedule
A) will be conducted separately for each Product in each country. 

  
 4 

 A&R OPTION AGREEMENT 

 

 (iv)    Compulsory Licenses. In the event that a court or a
governmental agency of competent jurisdiction requires AstraZeneca or an AstraZeneca Affiliate or Sublicensee to grant a compulsory license to a Third Party permitting such Third Party to make and sell the Product in a country in the Territory, then
for the purposes of calculating the Option Exercise Earn-Out payments of such Product under Paragraph 2.3(a) (Schedule A), [***] will be disregarded. The calculation of the Option Exercise Earn-Out reduction under this Paragraph 2.3(c)(iv) will be conducted separately for each Product. 

(v)    In-License Payments. 

(A)    Moderna Collaboration In-Licenses. If any In-License Payment becomes due under any Moderna Collaboration In-License with respect to the applicable Optioned Product Candidate prior to expiration of the Earn-Out Term for such Optioned Product Candidate, Moderna will pay same and, subject to [***] and Section 2.8(b) of the A&R Services and Collaboration Agreement, AstraZeneca will reimburse Moderna for
[***] of [***] within [***] days of receipt of Moderna’s written invoice therefor. To the extent that any grant of a sublicense by AstraZeneca or any Sublicensees under an Moderna Collaboration In-License
triggers a payment obligation under such Moderna Collaboration In-License, Moderna will pay same and AstraZeneca will reimburse Moderna for [***] of [***] within [***] days of receipt of Moderna’s written
invoice therefor. 
 (B)    Moderna [***] In-Licenses. Notwithstanding
Paragraph 2.3(c)(v)(A), if during the Option Agreement Term, any In-License Payments become due under any Moderna Collaboration In-License that is [***] as a result
of the grant of a sublicense thereunder to AstraZeneca or any further Sublicensees of AstraZeneca (including of AstraZeneca’s Affiliates that are granted sublicenses), (i) AstraZeneca will reimburse Moderna for [***] of [***] within [***]
days of receipt of Moderna’s written invoice therefor, and (ii) any such In-License Payments (excluding [***]) will be subject to Paragraph 2.3(c)(ii) (Schedule A) to the extent applicable
thereunder. Notwithstanding the foregoing, [***]. To the extent that any grant of a sublicense by AstraZeneca or any Sublicensees under an Moderna Collaboration In-License that is a [***] triggers a payment
obligation under such Moderna Collaboration In-License, Moderna will pay same and AstraZeneca will reimburse Moderna for [***] of [***] within [***] days of receipt of Moderna’s written invoice therefor.

 (d)    Payment Floor. In no event will any credits, deductions or reductions permitted to be taken under this
Schedule A, the Option Agreement or any other Transaction Agreement against any particular Contingent Event Option Exercise Payment or Option Exercise Earn-Out payment owed to Moderna
under this Schedule A (including pursuant to Paragraph 2.3(c) (Schedule A))act to reduce such payment by more than [***]; provided, that [***]. 

(e)    Additional Option Exercise Earn-Out Provisions. The Option Exercise Earn-Out payable under Paragraph 2.3(a) (Schedule A) will be subject to the following: 

(i)    only one Option Exercise Earn-Out will be payable under this
Schedule A with respect to each Product unit; 

  
 5 

 A&R OPTION AGREEMENT 

 

 (ii)    except as otherwise expressly provided in this
Schedule A, the Option Agreement and the other Transaction Agreements, the Option Exercise Earn-Out when owed or paid under this Schedule A will be nonrefundable and non-creditable and not subject to set-off; and 

(iii)    except as expressly set forth in Paragraph 2.3(c) (Schedule A), no other Option Exercise Earn-Out credits, reductions or deductions are permitted under this Schedule A. 

2.4    Payment Terms. 

(a)    Manner of Payment. All payments to be made by AstraZeneca to Moderna under this
Schedule A will be made in U.S. dollars. All payments to be made by AstraZeneca to Moderna under this Schedule A will be made by wire transfer in immediately available funds to such bank account as
Moderna may designate by written notice to AstraZeneca. 
 (b)    Reports and Payments. For as long as any Earn-Out payments are due under this Schedule A, AstraZeneca will furnish to Moderna a written report, after the end of each Calendar Quarter, showing the amount of Net Sales due for such
Product, which report will be furnished within [***] days of the end of the Calendar Quarter for which the Earn-Out payments are due. Earn-Out payments for each Calendar
Quarter will be due at the same time as such written reports for the Calendar Quarter. The reports will include, at a minimum, [***]. After receiving such written report, Moderna will submit an invoice to AstraZeneca for all Earn-Out payments, if requested by AstraZeneca (and any request or delivery of any such invoice will not extend the payment deadline specified above). AstraZeneca will provide to Moderna a form invoice for use by
Moderna in issuing any invoice under the Transaction Agreements. 
 (c)    Records and Audits. AstraZeneca will
keep, and will cause each of the other Selling Parties, as applicable, to keep, and Moderna will keep, adequate books and records of accounting for the purpose of calculating all Exercise Price payable by Moderna to AstraZeneca under this
Schedule A and ensuring Moderna’s compliance under this Schedule A. Such books and records will be maintained by AstraZeneca for at least [***] from the date of creation. During the Option
Agreement Term, such books and records of accounting (including those of the other Selling Parties, as applicable) will be kept at each of their principal places of business. At the request of Moderna, AstraZeneca will, and AstraZeneca will cause
each of the other Selling Parties to, permit an independent certified public accounting firm of nationally recognized standing selected by Moderna and reasonably acceptable to AstraZeneca, during normal business hours and upon reasonable notice, to
examine the books and records maintained pursuant to this Paragraph 2.4(c) (Schedule A). Such examinations may not (i) be conducted for any calendar year after the end of the Option Agreement Term (except that the books and records relating to
the last year of the Option Agreement Term may be examined for [***] after the end of the Option Agreement Term), (ii) be conducted more than [***] in any [***] period and going back no more than [***] after receipt of the respective invoice and
report or (iii) be repeated for any calendar year. Moderna will provide AstraZeneca with a copy of the accounting firm’s written report within [***] of completion of such report. Except as provided below, the cost of this examination will
be borne by Moderna, unless the audit reveals a variance of more than [***] from the reported amounts for a calendar year, in which case AstraZeneca will bear the reasonable
out-of-pocket cost of the audit, 

  
 6 

 A&R OPTION AGREEMENT 

 

 
provided such variance exceeds [***]. Unless disputed as described below, if such audit concludes that additional payments were owed or that excess payments were made during such period,
AstraZeneca will pay the additional amounts or Moderna will reimburse such excess payments, with interest from the date originally due as provided in Paragraph 2.4(f) (Schedule A), within [***] days after the date on which a written report of such
audit is delivered to the Parties. In the event of a dispute regarding such books and records, including the amount owed to Moderna under this Paragraph 2.4(c) (Schedule A), Moderna and AstraZeneca will work in good faith to resolve the
disagreement. If the Parties are unable to reach a mutually acceptable resolution of any such dispute within [***] days, such dispute will be resolved in accordance with the dispute resolution procedures set forth in Section 11.1 of the A&R
Services and Collaboration Agreement. The receiving Party will treat all information subject to review under this Paragraph 2.4(c) (Schedule A) in accordance with the confidentiality provisions of Section 11 of the Option Agreement, and
AstraZeneca will cause any accounting firm, auditor or arbitrator to enter into a reasonably acceptable confidentiality agreement with AstraZeneca obligating such firm to retain all such financial information in confidence pursuant to such
confidentiality agreement. Moderna may provide Third Parties to which Moderna owes payments on Products information in such audit report that are relevant and required to comply with such Third Party’s audit rights under the applicable license
agreement between Moderna and such Third Party, provided that such Third Party is obligated to keep such information confidential. 

(d)    Currency Exchange. With respect to Net Sales invoiced in U.S. dollars, the Net Sales and the amounts due to
Moderna under this Schedule A will be expressed in U.S. dollars. With respect to Net Sales invoiced in a currency other than U.S. dollars, payments will be converted from local currency to U.S. dollars by AstraZeneca in
accordance with the rates of exchange for the relevant month for converting such other currency into U.S. dollars used by AstraZeneca’s internal accounting systems, which are independently audited on an annual basis and which are in accordance
with generally accepted accounting principles, fairly applied and as employed on a consistent basis throughout AstraZeneca’s operations. 

(e)    Blocked Payments. In the event that, by reason of applicable Law in any country, it becomes impossible or
illegal for AstraZeneca (or any other Selling Party) to transfer, or have transferred on its behalf, payments owed Moderna under this Schedule A, AstraZeneca will promptly notify Moderna of the conditions preventing such
transfer and such payments will be deposited in local currency in the relevant country to the credit of Moderna in a recognized banking institution designated by Moderna or, if none is designated by Moderna within a period of [***] days, in a
recognized banking institution selected by AstraZeneca or another Selling Party, as the case may be, and identified in a written notice given to Moderna. 

(f)    Interest Due. If any payment due to either Party under this Schedule A is overdue
(and is not subject to a good faith dispute), then such paying Party will pay interest thereon [***] at an annual rate [***] of the lesser of (i) [***] and (ii) [***], such interest to run from the date upon which payment of such sum became due
until payment thereof in full together with such interest. 

  
 7 

 A&R OPTION AGREEMENT 

 

 2.5    Mutual Convenience of the Parties. The Exercise Price
payment obligations set forth under this Schedule A have been agreed to by the Parties for the purpose of reflecting and advancing their mutual convenience, including the ease of calculating and paying amounts to Moderna.
AstraZeneca hereby stipulates to the fairness and reasonableness of such payments obligations and covenants not to allege or assert, nor to allow any of its Sublicensees or Affiliates to allege or assert, nor further to cause or support any other
Third Parties to allege or assert, that any such payments obligations are unenforceable or illegal in any way. 

  
 8 

 A&R OPTION AGREEMENT 

 

 Schedule B 

Product Commercialization Schedule 
 This
Product Commercialization Schedule will apply to each Optioned Product Candidate (and all associated Development Pool Candidates) on an Optioned Product
Candidate-by-Optioned Product Candidate and Product-by-Product basis in all respects. For
each such Optioned Product Candidate, Development Pool Candidates and Products, Schedule A will also apply. 
  

	1.	 Definitions. 

The following terms will have the meanings set forth below. Capitalized terms used, but not defined herein, will have the meanings ascribed to such terms in
the Option Agreement and the other Transaction Agreements. 
 1.1    “AstraZeneca
Development & Commercialization Program” means a Development and Commercialization program for Product and the related Subject Constructs in the Subject Field. 

1.2    “Earn-Out Term” has the meaning set forth in
Section 6.1. 
 1.3    “Product Schedule Date” means the date on which a Product Candidate becomes
an Optioned Product Candidate. 
 1.4    “Subject Constructs” means the Optioned Product Candidate and
the Subject Development Pool Candidates. 
 1.5    “Subject Development Polypeptide” means the
Polypeptide [***] by the Optioned Product Candidate, as set forth in the AstraZeneca Option Notice. 

1.6    “Subject Development Pool Candidates” means, other than the Optioned Product Candidate, those
Development Pool Candidates [***] the Subject Development Polypeptide, as set forth in the AstraZeneca Option Notice. 

1.7    “Subject Field” means the applicable AstraZeneca Field, as set forth in the AstraZeneca Option
Notice. 
 1.8    “Subject Research Target” means the Research Target for the Subject Development
Polypeptide, as set forth in the AstraZeneca Option Notice. 
  

	2.	 Development and Commercialization Activities. 

2.1    Subject Research Target. The Subject Research Target will continue as a Research Target under the Transaction
Agreements unless AstraZeneca’s rights to Product and the related Subject Constructs are terminated in accordance with Section 13.2 or Section 13.3 of the A&R Option Agreement or Section 2.2(c) or Section 6.2 hereof.

  
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 A&R OPTION AGREEMENT 

 

 2.2    Diligence. 

(a)    As of and after the Product Schedule Date, AstraZeneca will have sole responsibility for, and control of, Exploiting
Product and the related Subject Constructs in the Subject Field worldwide, and will establish an AstraZeneca Development & Commercialization Program for that purpose. Except as provided in the A&R Services and Collaboration Agreement or
the Master Supply Agreements, as of and after the Product Schedule Date, AstraZeneca will have sole responsibility for all costs and expenses arising from Exploiting Product and the related Subject Constructs in the Subject Field worldwide. 

(b)    As of and after the Product Schedule Date, AstraZeneca, directly or through one or more of its Affiliates or
Sublicensees, will use Commercially Reasonable Efforts (i) to Develop [***] in the Subject Field and to obtain Regulatory Approval therefor; and (ii) on obtaining Regulatory Approval, to Commercialize a Product in the Subject Field
worldwide, provided that AstraZeneca will not be deemed to be in breach of its Commercially Reasonable Efforts under this clause (b) if [***]; provided, further, that [***]. 

(c)    During the Earn-Out Term, AstraZeneca may, by advance written notice to
Moderna of at least [***], elect to terminate all current and planned Development and Commercialization of Product and the related Subject Constructs with respect to a Subject Research Target, in which case Section 6.3 will apply with respect
to such Product and the related Subject Constructs. 
 2.3    Meetings and Reports. 

(a)    [***] during each Contract Year from the Product Schedule Date until the first approval of a BLA (or equivalent
Regulatory Approval) for Product, within [***] days of Moderna’s written request, the Parties will meet in person [***] for AstraZeneca to provide Moderna with an update on the Development and Commercialization of Product and the related
Subject Constructs. During such meeting, AstraZeneca will disclose to Moderna a summary of all material information regarding such Development and Commercialization. 

(b)    AstraZeneca will prepare and maintain, and will cause its Affiliates and Sublicensees to prepare and maintain,
reasonably complete and accurate records regarding the Development of Product and the related Subject Constructs, and the Commercialization of Product in the Subject Field worldwide after Regulatory Approval therefor. AstraZeneca will provide to
Moderna a reasonably detailed report regarding such efforts at least [***] each Contract Year during the Earn-Out Term. Such report will contain sufficient detail to enable Moderna to assess AstraZeneca’s
compliance with its Development and Commercialization obligations in Section 2.2, including [***]. AstraZeneca’s obligation to provide the information described in Section 2.3(b) to Moderna will terminate upon a Business Combination
of Moderna. 
  

	3.	 Regulatory Responsibilities. 

3.1    In General. AstraZeneca will lead and have sole control of all regulatory efforts for Product and the related
Subject Constructs worldwide, including with respect to preparing and filing the relevant Regulatory Filings and all communications with Regulatory Authorities. 

  
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 A&R OPTION AGREEMENT 

 

 3.2    Information Disclosure. Moderna will, and will cause its
Affiliates to, without additional compensation, disclose and make available to AstraZeneca [***] not otherwise provided to AstraZeneca under the Transaction Agreements, provided that Moderna and its Affiliates will not be required to disclose
or make available information relating to any mRNA Construct (other than a Collaboration mRNA Construct) being Developed or Commercialized by Moderna (alone or with other(s) by license or otherwise). 

3.3    Regulatory Filings. AstraZeneca will be responsible for preparing and submitting all Regulatory Filings
related to Product and the related Subject Constructs for use in the Subject Field, including all applications for Regulatory Approval. All applications for Regulatory Approval, the Regulatory Approvals, and other Regulatory Filings (including all
INDs) relating to Product and the related Subject Constructs will be the property of AstraZeneca and held in the name of AstraZeneca or its designees. 

3.4    Interactions with Regulatory Authorities. AstraZeneca will have the sole right to conduct all communications
with the Regulatory Authorities, including all meetings, conferences and discussions (including advisory committee meetings), with regard to Product and the Related Subject Constructs in the Territory. 

3.5    Cooperation. Without limiting the provisions of Section 3.4 of the A&R Option Agreement, for a
period of [***] after the Product Schedule Date, Moderna will cooperate with any reasonable requests for assistance from AstraZeneca with respect to obtaining any Regulatory Approval of Product and the related Subject Constructs and maintaining any
Regulatory Approval of Product and the related Subject Constructs that is held by AstraZeneca, including by: [***]. Assistance provided by Moderna to AstraZeneca pursuant to this Section 3.5 [***], as agreed in advance by AstraZeneca. An
estimate of such costs and expenses will be provided to AstraZeneca before the initiation of any agreed work. 

3.6    Adverse Event Reporting. Unless otherwise agreed by the Parties, the rights and obligations of the Parties
with respect to safety and related reporting activities with respect to Product and the related Subject Constructs will be set forth in a safety agreement to be entered into between the Parties (or their respective Affiliates) no later than the
[***] of the Product Schedule Date (or such later date as the Parties may agree). Such agreement will set forth terms and conditions with respect to such activities that are reasonable and customary in the industry for agreements of that nature, and
will be based on AstraZeneca’s standard form of safety agreement. Pursuant to the safety agreement, AstraZeneca will be responsible for adverse event reporting relating to Product and the related Subject Constructs to applicable Regulatory
Authorities in the Territory, and will be responsible for maintaining the global safety database with respect to Product and the related Subject Constructs. Moderna will assist AstraZeneca by reporting and providing to AstraZeneca all information
relating to adverse events to the extent that Moderna has any such data. Such data and other information will be provided in such a manner, time and format, and to such person(s) or department(s), as may be designated by AstraZeneca from time to
time, so as to enable AstraZeneca to comply with applicable Law. Moderna and AstraZeneca will reasonably cooperate to ensure that Moderna’s adverse event reporting processes will efficiently communicate such adverse event information in such
manner, time and format. 

  
 11 

 A&R OPTION AGREEMENT 

 

 3.7    Product Recalls. 

(a)    In the event that any government agency or authority issues or requests a recall or takes similar action in
connection with Product and the related Subject Constructs, or in the event either Party determines that an event, incident, or circumstance has occurred that may result in the need for a recall or market withdrawal, the Party notified of or
desiring such recall or market withdrawal will promptly advise the other Party thereof by telephone or facsimile. 

(b)    With respect to Product and the related Subject Constructs, AstraZeneca will decide and have control of whether to
conduct a recall or market withdrawal (except in the case of a government-mandated recall or withdrawal) in the Territory and the manner in which any such recall or market withdrawal will be conducted. The allocation of costs for any such recall or
market withdrawal will be set forth in the Master Supply Agreements. 
  

	4.	 Intellectual Property. 

4.1    Ownership. All Know-How, Materials and Patents conceived, discovered,
developed or otherwise made, by or on behalf of either Party (or its Affiliates or Sublicensees) either alone or jointly with Third Party(ies) or by the Parties or their Affiliates jointly under or in connection with this Product Commercialization
Schedule, whether or not conceived, discovered, developed or otherwise made at a facility owned or controlled by such Party and whether or not patented or patentable, and any and all Patent and other intellectual property rights with respect thereto
will be owned in accordance with inventorship and in accordance with applicable law in the United States. 

4.2    Patent Marking. AstraZeneca will mark, and will cause its Affiliates and Sublicensees to mark, Product with
all Patents within the [***] in accordance with applicable Law, which marking obligation will continue for as long as (and only for as long as) required under applicable Law. 
  

	5.	 Insurance. 

5.1    Insurance. Each Party will maintain at its sole cost and expense, an adequate liability insurance or
self-insurance program (including product liability insurance) to protect against potential liabilities and risk arising out of activities to be performed under this Product Commercialization Schedule, and any agreement related hereto and upon such
terms (including coverages, deductible limits and self-insured retentions) as are customary in the U.S. pharmaceutical industry for the activities to be conducted by such Party under this Product Commercialization Schedule. Subject to the preceding
sentence, such liability insurance or self-insurance program will insure against all types of liability, including personal injury, physical injury or property damage arising out of the Manufacture, sale, use, distribution or marketing of Product
and the related Subject Constructs. The coverage limits set forth herein will not create any limitation on a Party’s liability to the other under this Product Commercialization Schedule. 

  
 12 

 A&R OPTION AGREEMENT 

 

	6.	 Term and Termination. 

6.1    Term. This Product Commercialization Schedule will continue to apply to Product and the related Subject
Constructs, unless the A&R Option Agreement is sooner terminated with respect to such Product and the related Subject Constructs in accordance with Section 13.2 or Section 13.3 of the Option Agreement or Section 2.2 or
Section 6.2 hereof, on a country-by-country basis until there are no more Exercise Price payments owed Moderna on Product or the related Subject Constructs in such
country based on the applicable Schedule A to the Option Agreement (the longest such period of time for the Product hereunder, the “Earn-Out Term”). Upon there being
no more such payments hereunder for Product in such country, (a) the licenses contained in Section 3.1 of the A&R Option Agreement will become fully paid up, [***] and for clarity will remain exclusive with respect to Product and the
related Subject Constructs in such country; and (b) this Product Commercialization Schedule will expire with respect to such Product and the related Subject Constructs in such country. 

6.2    Termination for IP Challenge. Moderna will have the right to terminate this Product Commercialization
Schedule with respect to a Product and the related Subject Constructs upon written notice to AstraZeneca in the event that AstraZeneca or any of its Affiliates or Sublicensees challenges or directs a Third Party to challenge in a legal or
administrative proceeding the patentability, enforceability or validity of any Patents within the [***] covering such Product or the related Subject Constructs (a “Patent Challenge”); provided that Moderna will not have the
right to terminate this Product Commercialization Schedule under this Section 6.2 for any such Patent Challenge by any Sublicensee if such Patent Challenge is dismissed within [***] days of Moderna’s notice to AstraZeneca under this
Section 6.2 and not thereafter continued. 
 6.3    Effects of Termination or Expiration. Upon termination
(but not expiration pursuant to Section 6.1) of this Product Commercialization Schedule with respect to a Product and the related Subject Constructs for any reason: 

(a)    Wind Down. AstraZeneca will responsibly wind-down, in accordance with accepted pharmaceutical industry norms
and ethical practices, any on-going clinical trials with respect to such Product and the related Subject Constructs for which it has responsibility hereunder in which patient dosing has commenced or, if
reasonably practicable and requested by Moderna, AstraZeneca will transition such trials to Moderna or its designee. [***]. 

(b)    Schedule A. Any unpaid yet accrued Exercise Price attributable to such Product or the
related Subject Constructs will remain due and payable to Moderna, pursuant to Schedule A. Thereafter, the applicable Schedule A will immediately terminate and no further payments will be due
thereunder with respect to such Product or the related Subject Constructs. 
 (c)    Sublicenses. A termination
of this Product Commercialization Schedule will not automatically terminate any sublicense or rights to use or reference granted by AstraZeneca pursuant to Section 3.6 of the A&R Option Agreement for Development or Commercialization rights
with respect to a non-Affiliated Sublicensee, provided that (i) such Sublicensee is not then in material breach of any provision of this Product Commercialization Schedule or the applicable sublicense
agreement and (ii) [***]. AstraZeneca will include in any sublicense agreement that relates to the Moderna Technology a provision in which said Sublicensee acknowledges its obligations to Moderna under this Section 6.3(c). 

  
 13 

 A&R OPTION AGREEMENT 

 

 (d)    Cessation of Rights. Except as otherwise expressly provided
in Section 6.2, all rights and licenses granted by Moderna to AstraZeneca in Section 3.1 of the A&R Option Agreement with respect to such Product and the related Subject Constructs will terminate, and AstraZeneca and its Affiliates and
Sublicensees will, except as otherwise provided herein or in the Transaction Agreements, cease all Exploitation of Product and the related Subject Constructs and the use of the Moderna Technology in connection therewith. In addition, (i) the
Subject Constructs, the Subject Development Polypeptide, and Product will automatically become Discontinued Product Candidates, Discontinued Polypeptide and no longer a Product based on the definition thereof, respectively, and (ii) the Subject
Research Target will automatically become a Discontinued Target, unless for such Subject Research Target there [***]. In addition, AstraZeneca will promptly return to Moderna (or as directed by Moderna, destroy and certify to Moderna in writing as
to such destruction) all of Moderna’s Confidential Information that is solely related to Product or the related Subject Constructs and, provided Moderna reimburses AstraZeneca for the fully-burdened cost thereof, any inventory or samples of
Product or related Subject Constructs that are in AstraZeneca’s or its Affiliates’ or Sublicensees’ possession or control, save that AstraZeneca will have the right to retain (A) one (1) copy of such tangible Confidential
Information for legal purposes, and (B) any of the foregoing that AstraZeneca retains any license or other right hereunder or under the Option Agreement. 

(e)    Regulatory. Unless this Product Commercialization Schedule is terminated by AstraZeneca pursuant to
Section 13.3(a) of the A&R Option Agreement, to the extent permitted by applicable Law, all Regulatory Approvals and other regulatory filings and communications to the extent Controlled by AstraZeneca and its Affiliates for such Product or
the related Subject Constructs, as such items exist as of the effective date of such termination (including all completed and ongoing clinical trials that are solely related to such Product or the related Subject Constructs) will be assigned to
Moderna, and AstraZeneca will provide to Moderna one (1) copy of the foregoing, together with the raw and summarized data for any clinical trials (and where reasonably available, electronic copies thereof) in such form as it is then in
AstraZeneca’s possession. In the event of failure to obtain assignment, AstraZeneca hereby consents and grants to Moderna the right to access and reference (without any further action required on the part of AstraZeneca, whose authorization to
file this consent with any Regulatory Authority is hereby granted) any such item. 
 (f)    Licenses. Unless this
Product Commercialization Schedule is terminated by AstraZeneca pursuant to Section 13.3(a) of the Option Agreement with respect to a Product and the related Subject Constructs, AstraZeneca will grant to Moderna and its Affiliates, a worldwide,
[***], royalty-free and fully paid-up, nontransferable (except in connection with a permitted assignment of this Product Commercialization Schedule in accordance with Section 14.13 of the A&R Option
Agreement and the terms of this Product Commercialization Schedule), exclusive license, with the right to grant sublicenses through multiple tiers (subject to Section 3.6 of the A&R Option Agreement), under [***] to Exploit such
Product, the related Subject Constructs and any other mRNA Constructs [***] the related Subject Development Polypeptide. [***]; provided that [***]. 

  
 14 

 A&R OPTION AGREEMENT 

 

 (g)    Trademarks. Unless this Product Commercialization Schedule
is terminated by AstraZeneca pursuant to Section 13.3(a) of the A&R Option Agreement with respect to a Product and the related Subject Constructs, AstraZeneca will exclusively license to Moderna any registered or unregistered trademarks or
internet domain names that are specific to and solely used for such Product worldwide (it being understood that the foregoing will not include any trademarks or internet domain names that contain the corporate or business name(s) or other trademark
of AstraZeneca). 
 6.4    Survival. In addition to the termination consequences set forth in Section 6.3,
the following provisions will survive termination or expiration of this Product Commercialization Schedule: [***]. Termination or expiration of this Product Commercialization Schedule will not relieve the Parties of any liability or obligation which
accrued hereunder prior to the effective date of such termination or expiration nor preclude either Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Product Commercialization
Schedule nor prejudice either Party’s right to obtain performance of any obligation. All other rights and obligations with respect to such Product and the related Subject Constructs will terminate upon expiration of this Product
Commercialization Schedule with respect to such Product and the related Subject Constructs. 
  

	7.	 Assignment. 

[***] 

  
 15

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