Document:

EX-4.4

 Exhibit 4.4 
 THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), APPLICABLE STATE SECURITIES LAWS, OR
APPLICABLE LAWS OF ANY FOREIGN JURISDICTION. THIS WARRANT AND SUCH UNDERLYING SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE OFFERED, SOLD, PLEDGED, HYPOTHECATED, RENOUNCED OR OTHERWISE
TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT AND ANY APPLICABLE STATE SECURITIES LAWS AND IN THE ABSENCE OF COMPLIANCE WITH APPLICABLE LAWS OF ANY FOREIGN JURISDICTION, OR AN OPINION OF COUNSEL
SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED AND SUCH FOREIGN JURISDICTION LAWS HAVE BEEN SATISFIED. 

REGADO BIOSCIENCES, INC. 
 STOCK PURCHASE WARRANT 
 This Stock Purchase Warrant
is issued as of this 19th day of November, 2004, by Regado
Biosciences, Inc., a Delaware corporation (the “Company”), to University Medical Discoveries, Inc., or permitted assigns (the “Holder”). 
 1. Issuance of Warrant; Term; Price. 
 1.1 Issuance. The Company
hereby grants to Holder the right to purchase 41,500 shares of Common Stock of the Company (the “Warrant Stock”). 
 1.2 Term. The shares of Warrant Stock issuable upon exercise of this Warrant are hereinafter referred to as the “Shares.” This Warrant shall be exercisable at any time and from
time to time in whole or in part from the date hereof until November 19, 2014. 
 1.3. Exercise Price. The exercise
price (the “Warrant Price”) per share for which all or any of the Shares may be purchased pursuant to the terms of this Warrant shall be equal to $0.01, subject to adjustment as provided herein. 

2. Adjustment of Warrant Price, Number and Kind of Shares. The Warrant Price and the number and kind of securities issuable upon
the exercise of this Warrant shall be subject to adjustment from time to time and the Company agrees to provide notice upon the happening of certain events as follows. 
 2.1 Dividends in Stock Adjustment. In case at any time or from time to time on or after the date hereof the holders of the Common Stock of the Company (or any shares of stock or other securities at
the time receivable upon the exercise of this Warrant) shall have received, or, on or after the record date fixed for the determination of eligible stockholders, shall have become entitled to receive, without payment therefor, other or additional
securities or other property (other than cash) of the Company by way of dividend or distribution, then and in each case, the holder of 

 
this Warrant shall, upon the exercise hereof, be entitled to receive, in addition to the number of shares of Warrant Stock receivable thereupon, and without payment of any additional
consideration therefor, the amount of such other or additional securities or other property (other than cash) of the Company which such holder would hold on the date of such exercise had it been the holder of record of such Common Stock on the date
hereof and had thereafter, during the period from the date hereof to and including the date of such exercise, retained such shares and/or all other additional securities or other property receivable by it as aforesaid during such period, giving
effect to all adjustments called for during such period by this subsection 2.1 and subsections 2.2 and 2.3 of this Section 2. 
 2.2 Reclassification or Reorganization Adjustment. In case of any reclassification or change of the outstanding securities of the Company or of any reorganization of the Company (or any other
corporation the stock or securities of which are at the time receivable upon the exercise of this Warrant) on or after the date hereof, then and in each such case the Company shall give the holder of this Warrant at least thirty (30) days
notice of the proposed effective date of such transaction, and the holder of this Warrant, upon the exercise hereof at any time after the consummation of such reclassification, change or reorganization, shall be entitled to receive, in lieu of the
stock or other securities and property receivable upon the exercise hereof prior to such consummation, the stock or other securities or property to which such holder would have been entitled upon such consummation if such holder had exercised this
Warrant immediately prior thereto, all subject to further adjustment as provided in subsections 2.1 and 2.3 of this Section 2. 
 2.3 Stock Splits and Reverse Stock Splits. If at any time on or after the date hereof the Company shall subdivide its outstanding shares of Common Stock into a greater number of shares, the Warrant
Price in effect immediately prior to such subdivision shall thereby be proportionately reduced and the number of shares receivable upon exercise of this Warrant shall thereby be proportionately increased; and, conversely, if at any time on or after
the date hereof the outstanding number of shares of Common Stock shall be combined into a smaller number of shares, the Warrant Price in effect immediately prior to such combination shall thereby be proportionately increased and the number of shares
receivable upon exercise of this Warrant shall thereby be proportionately decreased. 
 3. No Fractional Shares. No
fractional shares of Warrant Stock will be issued in connection with any subscription hereunder. In lieu of any fractional shares that would otherwise be issuable, the Company shall pay cash equal to the product of such fraction multiplied by the
fair market value of one share of Warrant Stock on the date of exercise, as determined in good faith by the Company’s Board of Directors. 
 4. No Stockholder Rights. This Warrant as such shall not entitle its holder to any of the rights of a stockholder of the Company until the holder has exercised this Warrant in accordance with
Section 6 or Section 7 hereof. 
 5. Reservation of Stock. The Company covenants that during the period this
Warrant is exercisable, the Company will use its best efforts to reserve from its authorized and unissued Warrant Stock a sufficient number of shares to provide for the issuance of Warrant Stock upon the exercise of this Warrant. The Company agrees
that its issuance of this Warrant shall constitute full authority to its officers who are charged with the duty of executing stock certificates to execute and issue the necessary certificates for shares of Warrant Stock upon the exercise of this
Warrant. 

  
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 6. Exercise of Warrant. This Warrant may be exercised by Holder by the surrender of
this Warrant at the principal office of the Company, accompanied by payment in full of the purchase price of the shares purchased thereby, as described above. This Warrant shall be deemed to have been exercised immediately prior to the close of
business on the date of its surrender for exercise as provided above, and the person or entity entitled to receive the shares or other securities issuable upon such exercise shall be treated for all purposes as the holder of such shares of record as
of the close of business on such date. As promptly as practicable, the Company shall issue and deliver to the person or entity entitled to receive the same a certificate or certificates for the number of full shares of Warrant Stock issuable upon
such exercise, together with cash in lieu of any fraction of a share as provided above. The shares of Warrant Stock issuable upon exercise hereof shall, upon their issuance, be fully paid and nonassessable. Upon exercise of this Warrant, the Holder
will execute and become a party to the Shareholders Agreement, dated as of the date hereof, by and among Company and certain of Company’s shareholders. 
 7. Net Issue Election. 
 7.1 Right to Convert. In addition to and
without limiting the rights of the Holder under the terms of this Warrant, the Holder shall have the right to convert this Warrant or any portion hereof (the “Conversion Right”) into shares of Warrant Stock as provided in this
Section 7. Upon exercise of the Conversion Right with respect to a particular number of shares subject to this Warrant (the “Converted Warrant Shares”), the Company shall deliver to the Holder (without payment by the Holder of
any cash or other consideration) that number of shares of Common Stock equal to the quotient obtained by dividing (x) the value of this Warrant (or the specified portion hereof) on the Conversion Date (as defined in subsection 7.2 hereof),
which value shall be determined by subtracting (A) the aggregate Warrant Price of the Converted Warrant Shares immediately prior to the exercise of the Conversion Right from (B) the aggregate fair market value of the Converted Warrant
Shares issuable upon exercise of this Warrant (or the specified portion hereof) on the Conversion Date (as herein defined) by (y) the fair market value of one share of Common Stock on the Conversion Date (as herein defined). No fractional
shares shall be issuable upon exercise of the Conversion Right, and if the number of shares to be issued determined in accordance with the foregoing formula is other than a whole number, the Company shall pay to the Holder an amount in cash equal to
the fair market value of the resulting fractional share on the Conversion Date (as herein defined). 
 7.2 Method of
Exercise. The Conversion Right may be exercised by the Holder by the surrender of this Warrant at the principal office of the Company together with a written statement specifying that the Holder thereby intends to exercise the Conversion Right
and indicating the number of shares subject to this Warrant that are being surrendered (referred to in subsection 7.1 hereof as the Converted Warrant Shares) in exercise of the Conversion Right. Such conversion shall be effective upon such surrender
of this Warrant (the “Conversion Date”). Certificates for the shares of Common Stock issuable upon exercise of the Conversion Right (or any other securities deliverable in lieu thereof under Section 2) shall be issued as of the
Conversion Date and shall be delivered to the Holder immediately following the Conversion Date, or, if requested at the time of surrender of this Warrant, held for pick-up by the Holder at the Company’s principal office. 

  
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 7.3 Determination of Fair Market Value. For purposes of this Section 7, fair
market value (the “Market Price”) of a share of Common Stock as of a particular date (the “Determination Date”) shall mean the average of the closing prices of such security’s sales on the principal securities
exchanges on which such security may at the time be listed, or, if there has been no sales on any such exchange on any day, the average of the highest bid and lowest asked prices on all such exchanges at the end of such day, or, if on any day such
security is not so listed, the average of the last sale prices quoted in the NASDAQ System, or if on any day such security is not quoted in the NASDAQ System, the average of the highest bid and lowest asked prices on such day in the domestic
over-the-counter market as reported by the National Quotation Bureau, Incorporated, or any similar successor organization, in each such case averaged over a period of five (5) days consisting of the day prior to the day as of which “Market
Price” is being determined and the five (5) consecutive business days prior to such day. If at any time such security is not listed on any securities exchange or quoted in the NASDAQ System or the over-the-counter market, the “Market
Price” shall be the fair value thereof as determined in good faith by the Company’s Board of Directors. 
 8.
Certificate of Adjustment. Whenever the Warrant Price or number or type of securities issuable upon exercise of this Warrant is adjusted, as herein provided, the Company shall promptly deliver to the record holder of this Warrant a
certificate of an officer of the Company setting forth the nature of such adjustment and a brief statement of the facts requiring such adjustment. 
 9. Notice of Proposed Transfers. This Warrant is transferable by the Holder hereof subject to compliance with this Section 9. Prior to any proposed transfer of this Warrant or the shares of
Warrant Stock received on the exercise of this Warrant (the “Securities”), unless there is in effect a registration statement under the Securities Act of 1933, as amended (the “Securities Act”), covering the
proposed transfer, the Holder thereof shall give written notice to the Company of such Holder’s intention to effect such transfer. Each such notice shall describe the manner and circumstances of the proposed transfer in sufficient detail, and
shall, if the Company so requests, be accompanied (except in transactions in compliance with Rule 144) by an unqualified written opinion of legal counsel who shall be reasonably satisfactory to the Company addressed to the Company and reasonably
satisfactory in form and substance to the Company’s counsel, to the effect that the proposed transfer of the Securities may be effected without registration under the Securities Act or any other applicable foreign law, whereupon the Holder of
the Securities shall be entitled to transfer the Securities in accordance with the terms of the notice delivered by the Holder to the Company; provided, however, no such registration statement or opinion of counsel shall be necessary
for a transfer by a Holder to any affiliate of such Holder, or a transfer by a Holder which is a partnership to a partner of such partnership or a retired partner of such partnership who retires after the date hereof, or to the estate of any such
partner or retired partner or the transfer by gift, will or intestate succession of any partner to his spouse or lineal descendants or ancestors, if the transferee agrees in writing to be subject to the terms hereof to the same extent as if such
transferee were the original Holder hereunder. Each certificate evidencing the Securities transferred as above provided shall bear the appropriate restrictive legend set forth above, except that such certificate shall not bear such restrictive
legend if in the opinion of counsel for the Company such legend is not required in order to establish compliance with any provisions of the Securities Act or other applicable foreign law. 

  
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 10. Replacement of Warrants. Upon receipt by the Company of evidence reasonably
satisfactory to the Company of the loss, theft, destruction or mutilation of the Warrant, and in the case of any such loss, theft or destruction of the Warrant, on delivery of an indemnity agreement or security reasonably satisfactory in form and
amount to the Company, and reimbursement to the Company of all reasonable expenses incidental thereto, and upon surrender and cancellation of the Warrant if mutilated, the Company will execute and deliver, in lieu thereof, a new Warrant of like
tenor. 
 11. Dividends and Distributions. For so long as any part of this Warrant remains outstanding and unexercised,
the Company will, upon the declaration of a cash dividend upon its Common Stock or other distribution to the Holders of its Common Stock and at least ten (10) days prior to the record date, notify the Holder hereof of such declaration, which
notice will contain, at a minimum, the following information: (i) the date of the declaration of the dividend or distribution, (ii) the amount of such dividend or distribution, (iii) the record date of such dividend or distribution,
and (iv) the payment date or distribution date of such dividend or distribution. The Holder shall, upon the exercise hereof, be entitled to receive, in addition to the number of shares of Common Stock receivable thereupon, and without payment
of any additional consideration therefor, the amount of such other or additional securities or other property (other than cash) of the Company which such Holder would hold on the date of such exercise had it been the holder of record of such Common
Stock on the date hereof and had thereafter, during the period from the date hereof to and including the date of such exercise, retained such shares and/or all other additional securities or other property receivable by it as aforesaid during such
period, giving effect to all adjustments pursuant to Section 2. 
 12. Miscellaneous. This Warrant shall be governed
by the laws of the State of Delaware. The headings in this Warrant are for purposes of convenience of reference only, and shall not be deemed to constitute a part hereof. The invalidity or unenforceability of any provision hereof shall in no way
affect the validity or enforceability of any other provisions. All notices and other communications from the Company to the holder of this Warrant shall be delivered personally or mailed by first class mail, postage prepaid, to the address furnished
to the Company in writing by the last holder of this Warrant who shall have furnished an address to the Company in writing, and if mailed shall be deemed given three (3) days after deposit in the U.S. Mail. 

13. Taxes. The Company shall pay all issue taxes and other governmental charges (but not including any income taxes of a Holder)
that may be imposed in respect of the issuance or delivery of the Shares or any portion thereof. 
 14. Amendment. Any
term of this Warrant may be amended with the written consent of the Company and the Holder. Any amendment effected in accordance with this Section 14 shall be binding upon the Holder of this Warrant, each future holder of such Warrant, and the
Company. 
 15. Remedies. In the event of any default or threatened default by the Company in the performance of or
observance with any of the terms of this Warrant, it is agreed that remedies at law 

  
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are not and will not be adequate for the Holder and that such terms may be specifically enforced by a decree for the specific performance of any agreement contained herein or by an injunction
against a violation of any of the terms hereof or otherwise. 
 IN WITNESS WHEREOF, the undersigned officer of the Company has
set his hands as of the date first above written. 
  

			
	REGADO BIOSCIENCES, INC.
		
	By:	 	/s/ Douglas Gooding
		 	Douglas Gooding, Chief Executive Officer

  
 6EX-4.5

 Exhibit 4.5 
 THIS WARRANT AND THE SHARES OF STOCK ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN
STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT AS PERMITTED UNDER THE ACT AND THE APPLICABLE STATE SECURITIES LAWS, PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM.
INVESTOR SHOULD BE AWARE THAT THEY MAY BE REQUIRED TO BEAR THE FINANCIAL RISKS OF THIS INVESTMENT FOR AN INDEFINITE PERIOD OF TIME. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER TO
THE EFFECT THAT ANY PROPOSED TRANSFER OR RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 
  

			
	Warrant No. W-2	 	[                    ]

 WARRANT TO PURCHASE
[                ] SHARES OF 

CAPITAL STOCK OF REGADO 
 BIOSCIENCES, INC. 
 The transferability of this Warrant 

is restricted as provided in Section 5 and in the 
 Exercise Notice hereof. 
 THIS CERTIFIES THAT for value received,
                , (together with successors and assigns, the “Holder”), is entitled to subscribe for and purchase
                 fully paid and non-assessable shares (as adjusted pursuant to the provisions hereof, the “Shares”) of common stock, par value
$0.001 per share (the “Common Stock”), of Regado Biosciences, Inc., a Delaware corporation (the “Company”), at an exercise price of $0.01 per share (such exercise price, as adjusted from time to time pursuant to the
provisions hereof, the “Exercise Price”) subject to the provisions and upon the terms and conditions set forth herein. This Warrant is being issued pursuant to that certain Note and Warrant Purchase Agreement dated as of the date
hereof (the “Purchase Agreement”) and is subject to its terms. Capitalized terms used herein and not otherwise defined shall have the respective meanings ascribed thereto in the Convertible Promissory Note issued to the Holder on
the date hereof (the “Note”) pursuant to the Purchase Agreement. 
 1. Term. This Warrant is exercisable
at any time after the closing of an Equity Financing (as defined in the Note) and prior to                      (the “Exercise
Period”). 
 2. Exercise of Warrant. This Warrant is exercisable at the option of the Holder hereof, in whole or
in part, at any time and from time to time during the Exercise Period by the surrender hereof (with the annexed Exercise Notice duly executed) at the principal office of the 

 
Company, together with payment to the Company, in cash or by certified or official bank check, of an amount equal to the Exercise Price multiplied by the number of Shares then being purchased.
Upon the purchase of less than all of the Shares purchasable hereunder, the Company shall cancel this Warrant upon the surrender hereof and shall execute and deliver to the Holder hereof a new Warrant of like tenor for the balance of the Shares
purchasable hereunder. 
 3. Net Issue Exercise. In lieu of exercising this Warrant pursuant to Section 2 above, the
Holder shall have the right to require the Company to convert this Warrant, in whole or in part, at any time and from time to time during the Exercise Period, into Shares (the “Conversion Right”) by the surrender of the Warrant,
together with written notice of intent to convert, at the principal office of the Company. Upon exercise of the Conversion Right, the Company shall deliver to the Holder (without payment by the Holder of any Exercise Price) that number of Shares
which is equal to the quotient obtained by dividing (x) the value of the number of Shares with respect to which the Conversion Right is being exercised (determined by subtracting the aggregate Exercise Price for the Shares with respect to which
the Conversion Right is being exercised from a number equal to the product of (i) the fair market value per Share (as determined in good faith by the Company’s Board of Directors) at such time, multiplied by (ii) the number of Shares
with respect to which the Conversion Right is being exercised), by (y) such fair market value per share. Any references in this warrant to the “exercise” of this Warrant, and the use of the term “exercise” herein, shall be
deemed to include (without limitation) any exercise of the Conversion Right. 
 4. Issuance of Certificates. Upon the
exercise of this Warrant, the issuance of certificates for Shares underlying this Warrant shall be made forthwith, and such certificates shall be issued (subject to the provisions of Section 5 hereof) in the name of, or in such names as may be
directed by, the Holder hereof; provided, however, that the Company shall not be required to pay any tax which may be payable in respect of any transfer involved in the issuance and delivery of any such certificates in a name other than that of the
Holder, and the Company shall not be required to issue or deliver such certificates unless or until the person or persons requesting the issuance thereof shall have paid to the Company the amount of such tax or shall have established to the
satisfaction of the Company that such tax has been paid. The person or persons in whose name(s) any certificate(s) representing Shares shall be issued upon exercise hereof shall be deemed to have become the holder(s) of record of, and shall be
treated for all purposes as the record holder(s) of, the Shares represented thereby, and such Shares shall be deemed to have been issued, immediately prior to the close of business on the date(s) upon which this Warrant is exercised. 

5. Restrictions on Exercise and Transfer. 
 5.1 Exercise. As a condition to the exercise hereof, the Holder shall make any truthful representation or warranty reasonably required to facilitate the application of any exemption(s) from federal
and state registration requirements in connection therewith. 
 5.2 Holder’s Intent. The Holder of this Warrant, by
acceptance hereof, represents and warrants to the Company that such Holder is acquiring this Warrant and the Shares for investment for the Holder’s own account and not with a view to, or for resale in connection with, any distribution thereof.

 5.3 Transfer. Neither this Warrant nor the Shares have been registered under the Act,
and none of the foregoing may be sold or transferred in whole or in part unless the Holder shall have first given notice to the Company describing such sale or transfer and furnished to the Company an opinion of counsel (which counsel and opinion
(in form and substance) shall be reasonably satisfactory to the Company) to the effect that the proposed sale or transfer may be made without registration under the Securities Act of 1933, as amended (the “Act”). 

5.4 Legends. Each certificate representing Shares purchased hereunder shall bear the following legends: 

(a) The following legend under the Act: 
 THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER
SUCH ACT, OR UNLESS THE CORPORATION HAS RECEIVED AN OPINION OF COUNSEL OR OTHER EVIDENCE, SATISFACTORY TO THE COMPANY AND ITS COUNSEL, THAT SUCH REGISTRATION IS NOT REQUIRED. 
 (b) Any legend imposed or required by the Company’s Bylaws or applicable state securities laws. 
 6. Adjustment of Exercise Price and Number of Shares for Subdivision or Combination of Common Stock. 
 6.1 Adjustments. 
 (1) Subdivision. In the event that the Company
at any time or from time to time after the date of this Warrant shall declare or pay any dividend on the shares of Common Stock payable in shares of Common Stock or in any right to acquire shares of Common Stock, or shall effect a subdivision of the
outstanding shares of Common Stock into a greater number of shares of Common Stock (by stock split, reclassification or otherwise), then the Exercise Price in effect immediately prior to such event shall, concurrently with the effectiveness of such
event, be decreased proportionately. 
 (2) Combination. In the event that at any time or from time to time after the
date of this Warrant the outstanding shares of Common Stock shall be combined or consolidated into a lesser number of shares of Common Stock (by reclassification or otherwise), then the Exercise Price in effect immediately prior to such event shall,
concurrently with the effectiveness of such event, be increased proportionately. 

 6.2 Adjustment for Reclassification. Exchange, or Substitution. In the event of any
reorganization or any reclassification of the capital stock of the Company, any consolidation or merger of the Company with or into another corporation or corporations or the conveyance of all or substantially all of the Company’s assets to
another corporation (except for any such transaction which is treated as a liquidation, dissolution or winding up of the Company), this Warrant shall thereafter be exercisable for the number of shares of stock or other securities or property
(including cash) to which a holder of the number of remaining Shares purchasable hereunder would have been entitled upon the record date of (or date of, if no record date is fixed) such reorganization, reclassification, consolidation, merger or
conveyance; and, in any case, appropriate adjustment (as determined by the Board of Directors) shall be made in the application of the provisions herein set forth with respect to the rights and interests thereafter of the Holder of this Warrant to
the end that the provisions set forth herein shall thereafter be applicable, as nearly as equivalent as is practicable, in relation to any shares of stock or the securities or property (including cash) thereafter deliverable upon the exercise of
this Warrant. 
 6.3 Notice to Holder. In the event the Company shall propose at any time during the term of this Warrant
to take any action described in Section 6.1 or 6.2 above, the Company shall notify the Holder not less than ten (10) calendar days in advance of the anticipated occurrence of such event or any earlier related record date. 

6.4 Adjustment to Number of Shares Purchasable Hereunder. Upon each adjustment of the Exercise Price pursuant to the provisions of
this Section 6, the number of Shares purchasable upon the exercise hereof shall be adjusted to the nearest whole number of Shares calculated by multiplying the Exercise Price in effect immediately prior to such adjustment by the number of
Shares purchasable upon the exercise hereof immediately prior to such adjustment and dividing the product so obtained by the Exercise Price in effect immediately after such adjustment; provided, however, that no such adjustment in the number of
Shares shall be made prior to a Financing. 
 6.5 Certificate as to Adjustments. Upon the occurrence of each adjustment
or readjustment of the Exercise Price and the number of Shares purchasable hereunder pursuant to this Section 6, the Company at its expense shall promptly compute such adjustments or readjustments in accordance with the terms hereof, and the
Company shall prepare and furnish to the Holder hereof a certificate executed by the Company’s President or principal financial officer setting forth such adjustments or readjustments and showing in detail the facts upon which such adjustments
or readjustments are based. The Company shall, upon the written request at any time of the Holder, furnish or cause to be furnished to such Holder a like certificate setting forth (i) such adjustments and readjustments, (ii) the applicable
Exercise Price at the time in effect, and (iii) the number of Shares and the amount, if any, of other property which at the time would be received upon the exercise hereof. 

 7. Exchange and Replacement of Certificate. 

7.1 This Warrant is exchangeable without expense, upon the surrender hereof by the registered Holder at the principal office of the
Company, for a new Warrant of like tenor and date representing in the aggregate the right to purchase the same number of Shares as are purchasable hereunder in such denominations as shall be designated by the Holder hereof at the time of such
surrender. 
 7.2 Upon receipt by the Company of evidence reasonably satisfactory to the Company of the loss, theft, destruction
or mutilation of this Warrant, and, in case of loss, theft or destruction, of indemnity or security reasonably satisfactory to the Company, and return and cancellation of this Warrant, if mutilated, the Company will make and deliver a new Warrant of
like tenor, in lieu of this Warrant. 
 8. Elimination of Fractional Interests. The Company shall not be required to
issue certificates representing fractions of Shares on the exercise of this Warrant, nor shall it be required to issue scrip or pay cash in lieu of fractional interests, it being the intent of the parties that all fractional interests shall be
eliminated. 
 9. Withholding Taxes. 
 9.1 Whenever Shares are to be issued upon the exercise of this Warrant, the Company shall have the right to require the Holder to remit to the Company in cash an amount sufficient to satisfy U.S. federal,
state and local withholding tax requirements, if any, prior to the delivery of any certificate or certificates for such Shares. 

9.2 Notwithstanding Section 9.1, at the election of a Holder, subject to the approval of the Board of Directors of the Company, when
Shares are to be issued upon the exercise of this Warrant, the Holder may tender to the Company a number of Shares, or the Company shall withhold a number of such Shares, the fair market value of which is sufficient to satisfy the tax requirements,
if any, attributable to such exercise or occurrence. 
 10. Reservation of Securities. The Company shall at all times
reserve and keep available out of its authorized but unissued shares of Common Stock, solely for the purpose of issuance upon the exercise of this Warrant, such number of shares of Common Stock as shall be issuable upon the exercise hereof. The
Company covenants and agrees that, upon exercise of this Warrant and payment of the Exercise Price therefore, all Shares issuable upon such exercise shall be duly and validly issued, fully paid and non-assessable. 

11. No Rights as Shareholders. Nothing contained in this Warrant confers or shall be construed as conferring upon the Holder
hereof the right to vote or to consent or to receive notice as a shareholder in respect of any meetings of shareholders for the election of directors or any other matter, or as having any rights whatsoever as a shareholder of the Company.

 12. Notices. All notices, requests, consents and other communications hereunder shall be in writing and shall be
deemed to have been duly made when delivered, when sent by a nationally recognized overnight courier or when mailed by registered or certified mail, return receipt requested: 
 (a) If to the registered Holder of this Warrant, to the address of such Holder as shown on the books of the Company; or 

 (b) If to the Company, to Regado Biosciences, Inc., P.O. Box 14688, Research Triangle Park,
NC 27709 or to such other address as the Company may designate by notice to the Holder. 
 13. Successors. All of the
covenants, agreements, representations and warranties contained in this Warrant shall bind the parties hereto and their respective heirs, executors, administrators, distributees, successors and assigns. 

14. Headings. The headings in this Warrant are intended for convenience only and shall have no substantive effect. 

15. Law Governing. This Warrant shall be construed and enforced in accordance with, and governed by, the laws of the State of
North Carolina, without giving effect to conflict of law principles. 
 16. Amendment. The provisions of this Warrant may
be waived, amended, supplemented or modified (either prospectively or retroactively) by the written agreement of the Company and the Holders of the right to purchase at least a majority of the remaining Shares purchasable hereunder or in accordance
with the Purchase Agreement. 
 [signature page to follow] 

 [signature page to Warrant] 

 

			
	 REGADO BIOSCIENCES, INC.

		
	By:	 	
	Name:	 	Douglas Gooding
	Title:	 	President

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