Document:

Prepared by R.R. Donnelley Financial -- Amendment Certification of Designation 02/18/2000

  
  EXHIBIT 4.5 
  
 AMENDMENT TO THE CERTIFICATE OF DESIGNATION, 
 PREFERENCES AND RIGHTS OF 
 THE SERIES L PREFERRED STOCK OF 
 RIBOZYME PHARMACEUTICALS, INC. 
 DATED APRIL 30, 1999 
  
 Ribozyme Pharmaceuticals, Inc., a company organized and existing under the laws of the
State of Delaware (the “Corporation”), hereby certifies that the following resolutions were adopted by the Board of Directors of the Corporation pursuant to the authority of the Board of Directors as provided in the Corporation’s
Certificate of Incorporation, and by the sole holder of the Series L Preferred Stock of the Corporation pursuant to the General Corporation Law of Delaware: 
  
 RESOLVED, that the first sentence of Section E(5)(f) of the Certificate of Designations, Preferences and Rights of Series L Preferred Stock of the Corporation filed
with the Delaware Secretary of State on April 30, 1999, be deleted and replaced with the following sentence: 
  
 “RPI shall reserve and keep available from time to time such amount of its authorized but unissued shares of common stock as is reasonably sufficient to provide for the conversion of the Series L Preferred.” 

 
 RESOLVED FURTHER, that the Amendment to the Certificate of Designations, Preferences and Rights of Series L Preferred
Stock, in substantially the form attached hereto as Exhibit A (“Amendment”), is hereby authorized and approved and the appropriate officers of the Corporation are hereby authorized to execute, file and deliver such Amendment with the
Delaware Secretary of State; 
  
 RESOLVED FURTHER, that the officers of the Company be, and each of them hereby
is, authorized and directed, in the name and on behalf of the Company or otherwise, to make all such arrangements, to do and perform all such acts and things, and to execute and deliver all such officers’ certificates and such other instruments
and documents as they may deem necessary or appropriate in order to effectuate fully the purpose of each and all the foregoing resolutions (hereby ratifying and confirming any and all actions taken heretofore and hereafter to accomplish such
purposes, all or singular). 
  
 IN WITNESS WHEREOF, this Amendment to the Certificate of Designation, Preferences and Rights
of the Series L Preferred Stock of the Corporation dated April 30, 1999, is executed on behalf of the Corporation this 18th day of February, 2000. 
  

	 	. 
 

 
	 RIBOZYME PHARMACEUTICALS, INC
 
	 
	 By:
 	 	 /s/    LAWRENCE E. BULLOCK      
 

	  	 	 Lawrence E. Bullock, Vice President of Administration and Finance, CFO and SecretaryPrepared by R.R. Donnelley Financial -- Amendment to Certificate of Designation 05/01/2000

 EXHIBIT 4.6 
  
 AMENDMENT TO
THE CERTIFICATE OF DESIGNATION, 
 PREFERENCES AND RIGHTS OF 
 THE SERIES L PREFERRED STOCK OF

 RIBOZYME PHARMACEUTICALS, INC. 
 DATED APRIL 30, 1999, AS AMENDED FEBRUARY 18, 2000

  
 Ribozyme Pharmaceuticals, Inc., a company organized and existing under the laws of the State of Delaware (the
“Corporation”), hereby certifies that the following resolutions were adopted by the Board of Directors of the Corporation pursuant to the authority of the Board of Directors as provided in the Corporation’s Certificate of
Incorporation, and by the sole holder of the Series L Preferred Stock of the Corporation pursuant to Section 242 of the General Corporation Law of Delaware: 
  
 RESOLVED, that the first sentence of Section E(5)(f) of the Certificate of Designations, Preferences and Rights of Series L Preferred Stock of the Corporation filed
with the Delaware Secretary of State on April 30, 1999, as amended February 18, 2000, be deleted and replaced with the following sentence: 
  
 “RPI shall at all times reserve and keep available, out of its authorized but unissued shares of Common Stock, solely for the purpose of effecting the conversion of the shares of Series L Preferred at the time
outstanding, 1,500,000 shares of Common Stock.” 
  
 RESOLVED FURTHER, that the Amendment to the Certificate of Designations,
Preferences and Rights of Series L Preferred Stock, in substantially the form attached hereto as Exhibit A (“Amendment”), is hereby authorized and approved and the appropriate officers of the Corporation are hereby authorized to execute,
file and deliver such Amendment with the Delaware Secretary of State; 
  
 RESOLVED FURTHER, that the officers of the Company be,
and each of them hereby is, authorized and directed, in the name and on behalf of the Company or otherwise, to make all such arrangements, to do and perform all such acts and things, and to execute and deliver all such officers’ certificates
and such other instruments and documents as they may deem necessary or appropriate in order to effectuate fully the purpose of each and all the foregoing resolutions (hereby ratifying and confirming any and all actions taken heretofore and hereafter
to accomplish such purposes, all or singular). 
 

 1 

 IN WITNESS WHEROF, this Amendment to the certificate of Designation, Preferences and Rights of the Series L Preferred Stock of
the Corporation is executed on behalf of the Corporation this 27th day of April, 2000. 
  
 
	 RIBOZYME PHARMACEUTICALS, INC.
 
	 
	 By:
 	 	 /s/    LAWRENCE E. BULLOCK
        
 

	  	 	 Lawrence E. Bullock, Vice President of Administration and Finance, CFO and Secretary
 

 

	 	

  
 

 2Prepared by R.R. Donnelley Financial -- Amendment to Certificate of Designation

  
 EXHIBIT 4.7 
  
 CERTIFICATE OF AMENDMENT 
 OF 
 CERTIFICATE OF DESIGNATIONS,
PREFERENCES, AND RIGHTS 
 OF 
 SERIES A PREFERRED STOCK AND SERIES B PREFERRED STOCK

 OF 
 RIBOZYME PHARMACEUTICALS, INC. 
  

 
 Under Section 242 of the 
 Delaware General Corporation Law 
  
 
 
  
 RIBOZYME PHARMACEUTICALS, INC., a corporation organized and existing under and by virtue of the General Corporation Law of the State of Delaware (the “Corporation”), does
hereby certify that: 
  
 1.  The Board of Directors of the Corporation duly adopted the following
resolutions, pursuant to Section 242 of the Delaware General Corporate Law, setting forth certain amendments to the Certificate of Designations, Preferences, and Rights of Series A Preferred Stock and Series B Preferred Stock of Ribozyme
Pharmaceuticals, Inc. (the “Proposed Amendments”): 
  
 RESOLVED, that the Board of Directors of the
Corporation deems it advisable to amend the Certificate of Designations, Preferences, and Rights of Series A Preferred Stock and Series B Preferred Stock of the Corporation (the “Certificate of Designations”) in order to extend the first
date after which the Series A Preferred Stock may be converted into shares of Common Stock from the date that is 24 months after the issuance of the Series A Preferred Stock (January 7, 2002) to the date certain of October 7, 2002, by deleting the
first sentence of Section 4(a)(i) of the Certificate in its entirety and replacing it with the following: 
  
 “Each share of Series A Preferred Stock shall be convertible, at the option of the holder thereof, at any time after October 7, 2002, at the office of the Corporation or any transfer agent for such stock, into such number of fully paid
and non–assessable shares of Common Stock as is determined by dividing (x) the sum of the 

  
 Original Issue Price of such share of Series A Preferred Stock and all accrued and unpaid
dividends thereon by (y) the Series A Conversion Price (as defined below).” 
  
 RESOLVED, that the Board of
Directors of the Corporation also deems it advisable to amend the Certificate of Designations in order to extend the first date after which the holders of the Series A Preferred Stock may exercise the Exchange Right (as set forth in Section 5 of the
Certificate of Designations) from the date that is 24 months after the issuance of the Series A Preferred Stock (January 7, 2002) to the date certain of October 7, 2002, by deleting the second full paragraph of Section 5 of the Certificate and
replacing it with the following: 
  
 “The rights of the holders to exercise the Exchange Right shall
commence at any time after October 7, 2002 and shall terminate and be of no further force and effect on the date that is the later of (i) seven months thereafter and (ii) the completion of Newco’s development period, as agreed in the business
plan of Newco and as set forth in the Subscription, Joint Development and Operating Agreement dated as of January 7th, 2000, among Elan Pharmaceuticals Technologies, a division of Elan Corporation, plc, an Irish public limited company, EIS, Elan
Pharma International Limited, an Irish corporation, Newco and the Corporation (the “Exchange Termination Date”).” 
  
 RESOLVED, that, in accordance with Section 242 of the Delaware General Corporate Law, the proposed amendments be submitted to the holders of Series A Preferred Stock for their approval. 
  
 2.  The Proposed Amendments were duly adopted in accordance with the provisions of Section 228 of the General Corporation
Law of the State of Delaware. 
  
 IN WITNESS WHEREOF, the Corporation has caused this Amendment to the Certificate of Designation
to be signed by its Chief Executive Officer and its Secretary this 21st day of December, 2001. 
  
 
	 RIBOZYME PHARMACEUTICALS, INC.
 
	 
	 /s/    HOWARD ROBIN 
 

	 Name: Howard Robin
 Title: Chief Executive Officer

	  	 	  
	 
	 /s/    LAWRENCE E. BULLOCK
 

	 Name: Lawrence E. Bullock
 Title: Secretary
 

 
 

 2<PAGE>

                                                                  Exhibit 10.30

                              AMENDMENT NO. 2 TO
        THE SECURITIES TRANSFER, RECAPITALIZATION AND HOLDERS AGREEMENT

          THIS AMENDMENT NO. 2 TO THE SECURITIES TRANSFER, RECAPITALIZATION
AND HOLDERS AGREEMENT, dated November 29, 2001 (the "Amendment"), is by and
among DELCO REMY INTERNATIONAL, INC., a Delaware corporation (the "Company"),
COURT SQUARE CAPITAL LIMITED, a Delaware corporation ("Court Square"), DRI GROUP
LLC, a Delaware limited liability company ("DRI Group"), BERKSHIRE HATHAWAY
INC., a Delaware corporation ("Berkshire"), the Individual Investors and
DRESDNER KLEINWORT CAPITAL PARTNERS 2001 LP, a Delaware limited partnership
(the "Purchaser"). The Company, Court Square, DRI Group, Berkshire, the
Individual Investors and the Purchaser are sometimes referred to herein
individually as a "Party"  and collectively as the "Parties."

                                   Background
                                   ----------

          A.   The Company, Court Square, DRI Group, World Equity Partners,
L.P., a Delaware limited partnership ("WEP"), DRI Acquisition Corporation, a
Delaware corporation ("DRI Acquisition") and the Individual Investors are
parties to that certain Securities Transfer, Recapitalization and Holders
Agreement, dated March 14, 2001 (the "Original Agreement").

          B.   The Original Agreement sets forth certain agreements and
understandings among the Parties thereto with respect to the stock of the
Company held by the Parties.

          C.   The Original Agreement was amended by Amendment No. 1 to the
Securities Transfer, Recapitalization and Holders Agreement dated June 27, 2001
by and among the Parties other than the Purchaser (the "First Amendment").

          C.   The Company, Court Square and the Purchaser have entered into
that certain Securities Purchase Agreement date of even date herewith (the
"Purchase Agreement"). Pursuant to the Purchase Agreement, Court Square shall
sell to the Purchaser, and the Purchaser shall purchase, 90,406.62 shares of
the Company's 12% Series A Cumulative Compounding Preferred Stock, par value
$.01 per share (the "Series A Preferred Stock") and 97,808.33 shares of the
Company's Class C Common Stock, par value $.001 per share.

          D.   In connection with, and as a condition to, the transactions
contemplated by the Purchase Agreement, the Parties now desire to further amend
the Original Agreement in accordance with Section 8.1 thereof, as provided in
this Amendment.

                                      Terms
                                      -----

          In consideration of the mutual covenants contained herein and
intending to be legally bound hereby, the Parties hereby agree as follows:
<PAGE>

     Section 1.     Defined Terms. Capitalized terms not otherwise defined
                    -----------
herein shall have the respective meanings ascribed to such terms in the
Original Agreement.

     Section 2.     Status of Purchaser. Upon execution and delivery of this
                    -------------------
Amendment, the Purchaser shall become a party to the Original Agreement, shall
constitute an "Investor"  for all purposes under Sections 3.5, Article IV,
Article VII, and Article VIII of the Original Agreement and shall constitute an
"Institutional Investor"  for purposes of Section 4.2 of the Original Agreement.

     Section 3.     Purchaser Permitted Transferees. The Original Agreement is
                    -------------------------------
hereby amended by adding a new Section 3.5(b)(ix) immediately after Section
3.5(b)(viii) of the Agreement as follows:

               "(ix)     in the case of Dresdner Kleinwort Capital Partners 2001
          L.P. ("Dresdner") or its Permitted Transferees, (a) Dresdner or any
          of its Affiliates, or (b) any limited partnership, limited liability
          company or other investment vehicle that is sponsored or managed
          (whether through the ownership of securities having a majority of
          the voting power, as general partner or through the management of
          investments) by Dresdner or its Affiliates or by present employees
          of Dresdner or its Affiliates."

     Section 4.     Financial Statements and Other Information. The first
                    ------------------------------------------
paragraph of Section 4.2 of the Original Agreement is hereby stricken and
replaced in its entirety with the following:

               "Financial Statements and Other Information. After the Merger
                ------------------------------------------
          and so long as: (a) (i) any Institutional Investor, (ii) any
          Permitted Transferee of such Institutional Investor who owns or has
          the right to acquire 10% or more of the Common Stock outstanding, or
          (iii) Continuing Investor, as the case may be, owns any of the
          Securities, or (b) Dresdner Kleinwort Capital Partners 2001, L.P., a
          Delaware limited partnership ("Dresdner"), and its Permitted
          Transferees own, in the aggregate, 2% of the Common Stock
          outstanding calculated on a fully diluted basis, the Company shall
          deliver to such Institutional Investor, such Permitted Transferee,
          such Continuing Investor, and/or Dresdner, as applicable:"

     Section 5.     Amendment and Modification. Section 8.1 of the Original
                    --------------------------
Agreement is hereby stricken and replaced in its entirety with the following:

          "This Agreement may be amended or modified, or any provision hereof
          may be waived, provided that such amendment or waiver is set forth
          in a writing executed by (i) the Company, (ii) the holders of a
          majority of the Common Stock held by Court Square and its Permitted
          Transferees (so long as Court Square and its Permitted Transferees
          own in the aggregate at least 10% of the outstanding Common Stock

                                      - 2 -
<PAGE>

          on a fully diluted basis), (iii) the holders of a majority of the
          outstanding Common Stock on a fully diluted basis (including Shares
          owned by Court Square and its Affiliates), (iv) only with respect to
          amendments of Sections 4.5 and 6.3 hereof, the holders of a majority
          of the Common Stock held by the Management Investors if such
          amendment would materially adversely affect such Management
          Investors, (v) only with respect to any amendment, modification or
          waiver that would materially adversely affect rights or obligations
          of Berkshire Hathaway Inc. ("Berkshire") or its Permitted
          Transferees, Berkshire (so long as Berkshire and its Permitted
          Transferees own in the aggregate at least 10% of the outstanding
          Common Stock on a fully diluted basis) and (vi) only with respect to
          amendments of Sections 3.4, 4.2, 4.4, 4.5 and 8.1 hereof, the
          holders of a majority of the Common Stock held by Dresdner and its
          Permitted Transferees (so long as Dresdner and its Permitted
          Transferees own in the aggregate at least 2% of the outstanding
          Common Stock on a fully diluted basis) if such amendment would
          materially adversely affect the rights and obligations of Dresdner
          and its Permitted Transferees. Notwithstanding the foregoing, no
          amendment to this Agreement that joins any transferee(s) of Shares
          as an "Investor"  and/or an "Institutional Investor"  for all purposes
          hereunder shall be deemed to materially adversely affect the rights
          or obligations of the Management Investors, Berkshire and its
          Permitted Transferees or Dresdner and its Permitted Transferees by
          reason of such joinder. No course of dealing between or among any
          persons having any interest in this Agreement will be deemed
          effective to modify, amend or discharge any part of this Agreement
          or any rights or obligations of any person under or by reason of
          this Agreement."

     Section 6.     Continued Effect of Original Agreement. Except as
                    --------------------------------------
specifically amended herein, all other terms and provisions of the Original
Agreement, as amended by the First Amendment, shall remain unchanged and in
full force and effect.

     Section 7.     Incorporation of Amendment. On and after the date hereof
                    --------------------------
each reference in the Original Agreement to "this Agreement," "hereunder,"
"hereof," "herein" or words of like import shall be a reference to the Original
Agreement as amended by the First Amendment and hereby.

     Section 8.     Effectiveness. This Amendment shall be effective when
                    -------------
executed by the Company, Court Square, Berkshire and the Purchaser.

     Section 9.     Miscellaneous.
                    -------------

                    Section 9.1.    Entire Agreement. The agreement of the
                                    ----------------
Parties, which is comprised of this Amendment, the First Amendment and the
Original Agreement (including the

                                      - 3 -
<PAGE>

exhibits thereto), sets forth the entire agreement and understanding between
the Parties and supersedes any prior agreement or understanding, written or
oral, relating to the subject matter of this Amendment, the First Amendment and
the Original Agreement.

                    Section 9.2.    Governing Law. The validity, performance,
                                    -------------
construction and effect of this Amendment shall be governed by and construed in
accordance with the internal law of Delaware, without giving effect to
principles of conflicts of law.

                    Section 9.3.    Headings. The headings in this Amendment
                                    --------
are for convenience of reference only and shall not constitute a part of this
Amendment, nor shall they affect their meaning, construction or effect.

                    Section 9.4.    Counterparts. This Amendment may be
                                    ------------
executed in two or more counterparts and by the Parties in separate
counterparts, each of which when so executed shall be deemed to be an original,
and all of which taken together shall constitute one and the same instrument.

                            [Signature Pages Follow]

                                      - 4 -
<PAGE>

          IN WITNESS WHEREOF, the Parties have executed this Amendment upon
the day and year first above written.

                                           DELCO REMY INTERNATIONAL, INC.

                                           By: /s/ Thomas J. Snyder
                                              ------------------------------
                                              Name: Thomas J. Snyder
                                              Title: President and Chief
                                                     Executive Officer

                                           COURT SQUARE CAPITAL LIMITED

                                           By: /s/ Joseph Silvestri
                                              ------------------------------
                                              Name: Joseph Silvestri
                                              Title: Vice President

                                           DRI GROUP LLC

                                           By:
                                              ------------------------------
                                              Name:
                                              Title:

                                           BERKSHIRE HATHAWAY INC.

                                           By: /s/ Marc D. Hamburg
                                              ------------------------------
                                              Name: Marc D. Hamburg
                                              Title: Vice President
<PAGE>

          IN WITNESS WHEREOF, the Parties have executed this Amendment upon
the day and year first above written.

                                           MANAGEMENT INVESTORS:

                                           ____________________________________
                                           Thomas J. Snyder
                                           984 North 500 West
                                           Anderson, IN  46011

                                           ____________________________________
                                           J. Timothy Gargaro
                                           3245 Morningview Terrace
                                           Bloomfield Hills, Michigan 48301

                                           ____________________________________
                                           Joseph P. Felicelli
                                           10189 Summerlin Way
                                           Fishers, IN 46038

                                           ____________________________________
                                           Richard L. Stanley
                                           3028 West 53rd Street
                                           Anderson, IN 46011

                                           ____________________________________
                                           Susan E. Goldy
                                           11448 Lake Stonebridge Lane
                                           Fishers, IN 46038

                                           ____________________________________
                                           Roderick English
                                           205 South Creedmore Way
                                           Anderson, IN 46011

                                           ____________________________________
                                           Patrick C. Mobouck
                                           Grez-Doiceau, Belgium
                                           Alee De La Ferme Du Bercuit 5A
                                           B-1390, Hungary
<PAGE>

          IN WITNESS WHEREOF, the Parties have executed this Amendment upon
the day and year first above written.

                                           MANAGEMENT INVESTORS:

                                           ____________________________________
                                           Richard Keister
                                           110 Carolyn Drive
                                           Cross Junction, VA 22625

                                           DAISY FARM LIMITED PARTNERSHIP

                                           By:_________________________________
                                              Name:
                                              Title:

                                           ____________________________________
                                           Sandra M. Stanley
                                           3028 West 53rd Street
                                           Anderson, IN 46011
<PAGE>

          IN WITNESS WHEREOF, the Parties have executed this Amendment upon
the day and year first above written.

                                           CONTINUING INVESTORS:

                                           JAMES R. GERRITY LIVING TRUST DATED
                                           MARCH 6, 1990

                                           By:_________________________________
                                              Name:
                                              Title:

                                           SUSAN GERRITY LIVING TRUST DATED
                                           MARCH 6, 1990

                                           By:_________________________________
                                              Name:
                                              Title:
<PAGE>

          IN WITNESS WHEREOF, the Parties have executed this Amendment upon
the day and year first above written.

                                           PURCHASER:

                                           DRESDNER KLEINWORT CAPITAL
                                           PARTNERS 2001 LP

                                           By:   Dresdner Kleinwort Capital
                                                 2001 LLC
                                           Its:  General Partner
                                           By:   Private Equity Employees II LLC
                                           Its:  Managing Member

                                           By: /s/ Adam Lichtenstein
                                              ------------------------------
                                              Name: Adam Lichtenstein
                                              Its:  Authorized Person

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