Document:

EX-10.1

 Exhibit 10.1 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT MARKED WITH [***] HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT, AS AMENDED. 
  

 
 EXECUTION
VERSION 
 AMENDED AND RESTATED LICENSE, DEVELOPMENT AND COMMERCIALIZATION 

AGREEMENT 

by and between 
 ALLOS THERAPEUTICS, INC., 
 a
Delaware corporation 
 and 
 MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED, 
 a Bermuda corporation 

 TABLE OF CONTENTS 

 

					
	 	  	Page	 
	 ARTICLE 1 DEFINITIONS
	  	 	2	  
	 ARTICLE 2 LICENSES
	  	 	16	  
	 2.1 Licenses to Mundipharma
	  	 	16	  
	 2.2 License to Allos
	  	 	19	  
	 2.3 Negative Covenant
	  	 	20	  
	 2.4 No Implied Licenses
	  	 	20	  
	 ARTICLE 3 GOVERNANCE
	  	 	20	  
	 3.1 Joint Product Committee
	  	 	20	  
	 3.2 Joint Manufacturing Committee
	  	 	23	  
	 3.3 Good Faith
	  	 	23	  
	 3.4 Scope of Governance
	  	 	23	  
	 ARTICLE 4 PRODUCT DEVELOPMENT
	  	 	23	  
	 4.1 Overview
	  	 	23	  
	 4.2 Development Plan
	  	 	24	  
	 4.3 Omitted
	  	 	25	  
	 4.4 Future Development Activities
	  	 	25	  
	 4.5 Development Costs
	  	 	29	  
	 4.6 Diligence
	  	 	29	  
	 4.7 Investigator Sponsored Studies
	  	 	29	  
	 4.8 Data Exchange and Use
	  	 	30	  
	 4.9 Development Reports
	  	 	30	  
	 4.10 Development Records
	  	 	31	  
	 4.11 Compliance with Laws
	  	 	31	  
	 4.12 Allos’ Other Licensees
	  	 	31	  
	 ARTICLE 5 REGULATORY MATTERS
	  	 	31	  
	 5.1 Regulatory Responsibilities in the Licensed Territory
	  	 	31	  
	 5.2 Regulatory Responsibilities in the Allos Territory
	  	 	33	  
	 5.3 Regulatory Costs
	  	 	34	  
	 5.4 Rights of Reference to Regulatory Materials
	  	 	34	  
	 5.5 No Harmful Actions
	  	 	35	  
	 5.6 Notification of Threatened Action
	  	 	35	  
	 5.7 Adverse Event Reporting and Safety Data Exchange
	  	 	35	  
	 5.8 Remedial Actions
	  	 	35	  

  
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 TABLE OF CONTENTS 

(Continued) 
  

					
	 	  	Page	 
	 ARTICLE 6 COMMERCIALIZATION
	  	 	36	  
	 6.1 Overview of Commercialization in the Licensed Territory
	  	 	36	  
	 6.2 Commercialization Plan for Licensed Territory
	  	 	36	  
	 6.3 Pricing
	  	 	37	  
	 6.4 Pricing Approval
	  	 	37	  
	 6.5 Reimbursement Approval
	  	 	37	  
	 6.6 Commercial Diligence
	  	 	37	  
	 6.7 Cross-Territorial Restrictions
	  	 	38	  
	 6.8 Territorial Coordination
	  	 	39	  
	 6.9 Reports
	  	 	40	  
	 ARTICLE 7 COMPENSATION
	  	 	40	  
	 7.1 Upfront Payment
	  	 	40	  
	 7.2 Reimbursement of Joint Development Costs
	  	 	40	  
	 7.3 Milestone Payments
	  	 	41	  
	 7.4 Royalties
	  	 	42	  
	 7.5 Blocked Currency
	  	 	44	  
	 7.6 Foreign Exchange
	  	 	44	  
	 7.7 Payment Method; Late Payments
	  	 	45	  
	 7.8 Records
	  	 	45	  
	 7.9 Audits
	  	 	45	  
	 7.10 Taxes
	  	 	46	  
	 ARTICLE 8 INTELLECTUAL PROPERTY MATTERS
	  	 	47	  
	 8.1 Ownership of Inventions
	  	 	47	  
	 8.2 Disclosure of Inventions; Patent Strategy Consultation
	  	 	48	  
	 8.3 Prosecution of Patents
	  	 	48	  
	 8.4 Patent Enforcement in the Licensed Territory
	  	 	49	  
	 8.5 Patent Enforcement in the Allos Territory
	  	 	50	  
	 8.6 PDX Patents
	  	 	51	  
	 8.7 Infringement of Third Party Rights in the Licensed Territory
	  	 	51	  
	 8.8 Patent Marking
	  	 	52	  
	 8.9 Trademark Matters
	  	 	52	  
	 ARTICLE 9 REPRESENTATIONS AND WARRANTIES; COVENANTS
	  	 	56	  
	 9.1 Mutual Representations and Warranties
	  	 	56	  
	 9.2 Additional Representations and Warranties of Allos
	  	 	57	  

  
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 TABLE OF CONTENTS 

(Continued) 
  

					
	 	  	Page	 
	 9.3 Additional Representations and Warranties of Mundipharma
	  	 	61	  
	 9.4 Covenants
	  	 	61	  
	 9.5 No Other Representations or Warranties
	  	 	63	  
	 ARTICLE 10 INDEMNIFICATION
	  	 	63	  
	 10.1 Indemnification by Allos
	  	 	63	  
	 10.2 Indemnification by Mundipharma
	  	 	63	  
	 10.3 Shared Claims
	  	 	64	  
	 10.4 Indemnification Procedures
	  	 	64	  
	 10.5 Limitation of Liability
	  	 	65	  
	 10.6 Insurance
	  	 	65	  
	 ARTICLE 11 CONFIDENTIALITY
	  	 	65	  
	 11.1 Confidentiality
	  	 	65	  
	 11.2 Authorized Disclosure
	  	 	66	  
	 11.3 Technical Publication
	  	 	66	  
	 11.4 Publicity; Terms of Agreement
	  	 	67	  
	 11.5 Prior Confidentiality Agreements
	  	 	68	  
	 11.6 Return of Confidential Information
	  	 	68	  
	 11.7 Unauthorized Use
	  	 	68	  
	 11.8 Exclusive Property
	  	 	68	  
	 ARTICLE 12 TERM AND TERMINATION
	  	 	69	  
	 12.1 Term
	  	 	69	  
	 12.2 Termination for Breach
	  	 	69	  
	 12.3 Termination for Patent Challenge
	  	 	69	  
	 12.4 Unilateral Termination by Mundipharma
	  	 	69	  
	 12.5 Termination for Bankruptcy
	  	 	71	  
	 12.6 Effect of Termination
	  	 	72	  
	 12.7 Survival
	  	 	75	  
	 ARTICLE 13 DISPUTE RESOLUTION
	  	 	76	  
	 13.1 Arbitration
	  	 	76	  
	 13.2 Referred from JPC
	  	 	76	  
	 13.3 Equitable Relief
	  	 	77	  
	 13.4 Governing Law
	  	 	77	  
	 13.5 Patent and Trademark Disputes
	  	 	77	  

  
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 TABLE OF CONTENTS 

(Continued) 
  

					
	 	  	Page	 
	 ARTICLE 14 MISCELLANEOUS
	  	 	77	  
	 14.1 Entire Agreement; Amendment
	  	 	77	  
	 14.2 Force Majeure
	  	 	78	  
	 14.3 Notices
	  	 	78	  
	 14.4 No Strict Construction; Interpretation; Headings
	  	 	79	  
	 14.5 Assignment
	  	 	80	  
	 14.6 Performance by Affiliates
	  	 	80	  
	 14.7 Further Actions
	  	 	80	  
	 14.8 Severability
	  	 	80	  
	 14.9 No Waiver
	  	 	80	  
	 14.10 Independent Contractors
	  	 	80	  
	 14.11 English Language
	  	 	81	  
	 14.12 Counterparts
	  	 	81	  
	 14.13 Non-Solicitation of Employees
	  	 	81	  
	 14.14 Expenses
	  	 	81	  
	 14.15 Intellectual Property
	  	 	81	  
	 14.16 Modification of Licensed Territory
	  	 	81	  
	 14.17 Switzerland Option
	  	 	82	  
	 14.18 Amendment and Restatement
	  	 	82	  

  
 iv 

 AMENDED AND RESTATED LICENSE, DEVELOPMENT AND COMMERCIALIZATION 

AGREEMENT 

This AMENDED AND RESTATED LICENSE,
DEVELOPMENT AND COMMERCIALIZATION AGREEMENT (this “Agreement”) is entered into as of May 29, 2013 (the
“Effective Date”) by and between ALLOS THERAPEUTICS, INC., a Delaware corporation having a place of business
at 11080 Circle Point Road, Suite 430, Westminster, Colorado 80020, U.S. (“Allos”), and MUNDIPHARMA INTERNATIONAL CORPORATION
LIMITED, a Bermuda corporation having a place of business at Mundipharma House, 14 Par-la-Ville Road, P.O. Box HM 2332, Hamilton HM JX, Bermuda
(“Mundipharma”). Allos and Mundipharma are sometimes referred to herein individually as a “Party” and collectively as the
“Parties”. 
 RECITALS 

WHEREAS, Allos has rights to a proprietary anti-folate product known as pralatrexate (tradename
Folotyn), which has received an accelerated regulatory approval in the U.S. for treatment of patients with relapsed or refractory peripheral T-cell lymphoma and for which a drug approval application has been submitted to the European Medicines
Agency for treatment of patients with relapsed or refractory peripheral T-cell lymphoma; 

WHEREAS, Mundipharma possesses resources and expertise in the development, manufacture, marketing
and commercialization of pharmaceutical products; 
 WHEREAS, Allos and Mundipharma entered
into that certain License, Development and Commercialization Agreement, dated as of May 10, 2011 (the “Original Agreement”), pursuant to which Allos and Mundipharma agreed to collaborate to pursue regulatory approval of Folotyn
for relapsed or refractory peripheral T-cell lymphoma by the EMA, and in other countries in the Licensed Territory, and to collaborate in the development of Folotyn in other Oncology Indications, all pursuant to a mutually agreed development plan,
with Mundipharma having exclusive rights to develop and commercialize Folotyn for all indications in the Licensed Territory, and Allos retaining all other Folotyn commercialization rights, all on the terms and conditions set forth herein;

 WHEREAS, Mundipharma or its designee and Allos also entered into a separate Supply Agreement, dated as
of May 10, 2011, as amended and restated as of the date hereof (the “Supply Agreement”), pursuant to which Mundipharma or its designee agreed to purchase its requirements of Folotyn from Allos and Allos agreed to supply Folotyn
to Mundipharma or its designee on the terms and conditions set forth therein; and 
 WHEREAS, the Parties
desire to amend and restate the Original Agreement in order to modify the scope of the Licensed Territory and the respective Development obligations of the Parties, as more particularly set forth herein. 

NOW, THEREFORE, in consideration of the foregoing premises and the mutual promises,
covenants and conditions contained in this Agreement, the Parties hereby agree as follows: 

 ARTICLE 1 
 DEFINITIONS 
 1.1 Omitted. 

1.2 “Acquiror” has the meaning set forth in Section 14.5. 

1.3 “Active Pharmaceutical Ingredient” or “API” means [***]. 

1.4 “Additional Study” has the meaning set forth in Section 4.4(b). 

1.5 Omitted. 
 1.6 “Affiliate” means, with respect to either Party, any person, firm, trust, corporation, partnership or other entity or combination thereof that directly or indirectly controls, is
controlled by or is under common control with such Party; the term “control” (including, with correlative meaning, the terms “controlled by” or “under common control with”) meaning direct or indirect ownership of fifty
percent (50%) or more, including ownership by trusts with substantially the same beneficial interests, of the voting and equity rights of such person, firm, trust, corporation, partnership or other entity or combination thereof, or the power to
direct the management of such person, firm, trust, corporation, partnership or other entity or combination thereof. 
 1.7
Omitted. 
 1.8 “Allos-Facilitated ISS” means an ISS that Allos authorizes or facilitates in
accordance with Section 4.7. 
 1.9 “Allos Indemnitees” has the meaning set forth in Section 10.2.

 1.10 “Allos ISS Technology” means (a) all Information that (i) is necessary or useful for the
Development or Commercialization of a Product in the Field, (ii) is Controlled by Allos or its Affiliates during the Term, and (iii) arises from an Allos-Facilitated ISS, and (b) any Patent (other than a Joint Patent) that
(x) claims the Product or the API or the manufacture or use in the Field of the Product or the API, (y) is Controlled by Allos or its Affiliates during the Term, and (z) claims an invention arising from an Allos-Facilitated ISS;
provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Allos after the Effective Date due to a Change of Control of Allos, except to the extent such Third Party’s Information or
Patents are Controlled by Allos (or its Acquiror) or any of its other Affiliates and are necessary for the Development or Commercialization of the Product and are utilized in respect of the Product or the API in the Allos Territory. 

1.11 “Allos Know-How” means all Information that (a) is necessary or useful for the Development or Commercialization
of a Product in the Field but is not directed to the manufacture of a Product and (b) (i) is Controlled by Allos or its Affiliates as of the Effective Date or (ii) is Controlled by Allos or its Affiliates during the Term and arises
from a Shared Study (including any Incremental Study that becomes an Additional Study upon Mundipharma’s exercise of the Opt-In 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 2 

 
Right under Section 4.4(c)(v)); provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Allos after the Original Effective
Date due to a Change of Control of Allos, except to the extent such Third Party’s Information is Controlled by Allos (or its Acquiror) or any of its other Affiliates and is necessary for the Development or Commercialization of the Product and
is utilized in respect of the Product or the API in the Allos Territory; and provided further that, “Allos Know-How” excludes (x) Information arising from any Incremental Study (with respect to which Mundipharma does not exercise its
Opt-In Right under Section 4.4(c)(v)) or Investigator-Sponsored Study, and (y) Allos Manufacturing Know-How. 
 1.12
“Allos Manufacturing Know-How” means all Information that is necessary or useful for the manufacture and quality testing of a Product in the Field and is Controlled by Allos or its Affiliates as of the Effective Date or during the
Term; provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Allos after the Original Effective Date due to a Change of Control of Allos, except to the extent such Third Party’s
Information is Controlled by Allos (or its Acquiror) or any of its other Affiliates and is necessary for the manufacture of, and is utilized by or on behalf of Allos in respect of, the Product or the API in the Allos Territory or the Licensed
Territory. 
 1.13 “Allos Patent” means any Patent (other than a Joint Patent) that (a) claims the
Product or the API or the manufacture or use in the Field of the Product or the API and (b) (i) is Controlled by Allos or its Affiliates during the Term, (ii) is Controlled by Allos or its Affiliates on or after the Original Effective
Date and claims priority to a Patent Controlled by Allos or its Affiliates as of the Original Effective Date, or (iii) is Controlled by Allos or its Affiliates during the Term and claims an invention arising from a Shared Study (including any
Incremental Study that becomes an Additional Study upon Mundipharma’s exercise of the Opt-In Right under Section 4.4(c)(v)); provided, each Allos Patent in existence on the Original Effective Date is set forth in Schedule 1 hereto;
and provided further that (i) the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Allos after the Original Effective Date due to a Change of Control of Allos, except to the extent such
Third Party’s Patents are Controlled by Allos (or its Acquiror) or any of its other Affiliates and are necessary for the Development, Commercialization or manufacture of the Product and are utilized in respect of the Product or the API in the
Allos Territory and (ii) “Allos Patent” excludes any Patent that claims an invention arising from an Incremental Study (with respect to which Mundipharma does not exercise its Opt-In Right under Section 4.4(c)(v)) or
Investigator-Sponsored Study. 
 1.14 “Allos Payment-Allos Withholding Tax Action” has the meaning set
forth in Section 7.10(d)(i). 
 1.15 “Allos Payment-Mundipharma Withholding Tax Action” has the meaning set
forth in Section 7.10(d)(ii). 
 1.16 “Allos Prosecuted Patents” has the meaning set forth in
Section 8.3(a). 
 1.16A “Allos Required Study” means those clinical trials and/or studies set forth
on the Allos Required Studies Schedule with the scope and manner of conducting such clinical trials and/or studies being that required by FDA for Regulatory Approval in the U.S. as of the Effective Date. 

  
 3 

 1.16B “Allos Required Studies Schedule” means the schedule containing those
clinical trials and/or studies, which Allos is required to conduct in order to maintain its U.S. Regulatory Approvals, which is set forth in the Second Letter Agreement and as may be amended from time to time to, among other things, remove
the clinical trials and/or studies that (a) are no longer required by the FDA for Regulatory Approval or maintenance of Regulatory Approval in the U.S., or (b) for Material Impact or Safety Reason. 

1.17 “Allos Share” means sixty percent (60%). 
 1.18 Omitted. 
 1.19 “Allos Studies” has the meaning
set forth in Section 4.2(b). 
 1.20 “Allos Technology” means the Allos Know-How, Allos Patents and
Allos’ interest in Joint Patents. 
 1.21 “Allos Territory” means the U.S., Canada, the European Countries
and Turkey and (i) any country(ies) that is/are removed from the Licensed Territory and transferred to Allos Territory in accordance with Section 6.6(b), and (ii) Switzerland, upon the exercise by Allos of the Switzerland Option.

 1.22 “Allos Territory Infringement” has the meaning set forth in Section 8.5(a). 

1.23 “Amended Development Plan” has the meaning set forth in Section 4.2(b). 

1.24 Omitted. 
 1.25 “Bankruptcy Code” means, as applicable, the U.S. Bankruptcy Code, as amended from time to time, and the rules and regulations and guidelines promulgated thereunder or the bankruptcy
laws of any Governmental Authority, as amended from time to time, and the rules and regulations and guidelines promulgated thereunder. 
 1.26 “Breaching Party” has the meaning set forth in Section 12.2. 
 1.27 “Bulk Product” has the meaning set forth in the Supply Agreement. 
 1.28 “Canada” means Canada, including all possessions and territories thereof. 
 1.29 “Change of Control” means, with respect to either Party, (i) the sale of all or substantially all of such Party’s assets or business relating to this Agreement; (ii) a
merger, consolidation, share exchange or other similar transaction involving such Party and any Third Party which results in the holders of the outstanding voting securities of such Party immediately prior to such merger, consolidation, share
exchange or other similar transaction ceasing to hold more than fifty percent (50%) of the combined voting power of the surviving, purchasing or continuing entity immediately after such merger, consolidation, share exchange or other similar
transaction, or (iii) the acquisition by a person or entity, or group of persons or entities acting in concert, of more than fifty percent (50%) of the outstanding voting equity securities of such Party; in all cases of clauses
(i)-(iii), where such transaction is to be entered into with any person or group of persons other than the other Party or its Affiliates. 
 1.30 “Claims” has the meaning set forth in Section 10.1. 

  
 4 

 1.31 “Clinical Proof of Concept” means availability of human clinical data
confirming that the concept of a new Indication is feasible and that further investigation is reasonably likely to be capable of Drug Approval and Commercialization; provided, such data, with respect to new Indications, shall include efficacy and
safety data from a Phase 1 Study, Phase 1/2 study and/or Phase 2 Study, or, with respect to new formulations or routes of administration, shall include pharmacokinetic data from Phase 1 Studies. 

1.32 “CMC Information” means Information related to the chemistry, manufacturing and controls of the Product, as
specified by the FDA, EMA and other applicable Regulatory Authorities. 
 1.33 “Commercialization”, with
a correlative meaning for “Commercialize” and “Commercializing”, means all activities undertaken before and after obtaining Regulatory Approvals relating specifically to the pre-launch, launch, promotion, detailing,
medical education and medical liaison activities, marketing, pricing, reimbursement, sale and distribution of the Product, including strategic marketing, sales force detailing, advertising, medical education and liaison, and market and Product
support, and all customer support, Product distribution, invoicing and sales activities; provided, however, “Commercialization” shall exclude any activities relating to the manufacture of the Product. 

1.34 “Commercialization Plan” has the meaning set forth in Section 6.2(a). 

1.35 Omitted. 
 1.36 “Conducting Party” has the meaning set forth in Section 4.4(c)(i). 
 1.37 “Confidential Information” of a Party means any and all Information of such Party or its Affiliates that is disclosed by such Party or its Affiliates to the other Party or its
Affiliates under this Agreement or the Supply Agreement, whether in oral, written, graphic, or electronic form. 
 1.38
“Consent” means the consent and agreement among Allos, the PDX Licensor and Mundipharma, dated as of the Original Effective Date. 
 1.39 “Control” means, with respect to any material, Information, or intellectual property right, that a Party (a) owns or (b) has a license (other than a license granted to such
Party under this Agreement) to such material, Information, or intellectual property right, and in each case, has the ability to grant to the other Party access, a license or a sublicense (as applicable) to the foregoing on the terms and conditions
set forth in this Agreement without violating the terms of any then-existing agreement or other arrangement with any Third Party. 
 1.40 Omitted. 
 1.41 “Current Third Party
Manufacturer” means [***] (each as defined in the Supply Agreement). 
 1.42 “Default Notice” has the
meaning set forth in Section 12.2. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 5 

 1.43 “Develop” or “Development” means all activities
relating to preparing and conducting non-clinical studies, clinical studies, and regulatory activities (e.g., preparation of regulatory applications) that are necessary or useful to obtain and maintain Drug Approval of the Product.

 1.44 Omitted. 
 1.45 “Development Plan” has the meaning set forth in Section 4.2(a). 
 1.46 “Dollars” means U.S. dollars, and “$” shall be interpreted accordingly. 
 1.47 “Drug Approval” means an approval granted by the appropriate Regulatory Authority to market the Product in the Field in any particular jurisdiction in the Licensed
Territory. 
 1.48 “Drug Approval Application” or “DAA” means an
application to the appropriate Regulatory Authority for approval to market the Product in the Field in any particular jurisdiction in the Licensed Territory. 
 1.49 “eCTD” has the meaning set forth in Section 5.1(c). 

1.50 Omitted. 
 1.51 “EMA” means the European Medicines Agency or any successor entity. 
 1.52 “European Countries” means Austria, Belgium, Bulgaria, Croatia, Cyprus, the Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy,
Latvia, Liechtenstein, Lithuania, Luxembourg, Macedonia, Malta, Monaco, Montenegro, the Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden, and the United Kingdom. 

1.53 Omitted. 
 1.54 Omitted. 
 1.55 Omitted. 

1.56 “Executive Officers” has the meaning set forth in Section 3.1(d). 

1.57 “Existing Studies” has the meaning set forth in Section 4.2(b). 

1.58 “Expert” has the meaning set forth in Section 6.6(b). 

1.59 “FD&C Act” means the U.S. Federal Food, Drug and Cosmetic Act, as amended. 

1.60 “FDA” means the U.S. Food and Drug Administration or any successor entity. 

1.61 “Field” means the diagnosis or treatment of [***]. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 6 

 1.62 Omitted. 

1.63 Omitted. 
 1.64 “First Commercial Sale” means, with respect to a particular Product, the first sale to a Third Party of such Product in a given regulatory jurisdiction after Drug Approval has been
obtained in such jurisdiction. 
 1.65 “First Confidentiality Agreement” means the confidentiality agreement
between Allos and Mundipharma dated [***]. 
 1.66 Omitted. 

1.67 Omitted. 
 1.68 “First Line PTCL” means treatment of previously undiagnosed PTCL patients or treatment of previously undiagnosed PTCL patients who achieved an objective response following initial
treatment with CHOP-based chemotherapy, where “PTCL” for this purpose is defined by the population included in the PDX-017 study or any subsets of such population. 
 1.69 “First Reimbursable Commercial Sale” means, with respect to a particular Product, the first sale to a Third Party of such Product in a given regulatory jurisdiction after all
relevant Regulatory Approvals have been obtained in such jurisdiction. 
 1.69A “FTE” means the equivalent of
the work of one or more full time qualified individuals (e.g., having the requisite education and/or skills in the appropriate scientific or technical discipline to fulfill Mundipharma’s obligations under this Agreement) at Mundipharma or its
Affiliates who spend time and effort on a specific project or task in connection with the registration and maintenance of any Regulatory Approvals for the Product in the Field in Switzerland, as measured by Mundipharma’s time allocation
practices. 
 1.70 “Generic Product” means any pharmaceutical product in a particular regulatory jurisdiction
that (a) contains the same active pharmaceutical ingredients as the Product; (b) is bioequivalent to the Product as determined by the applicable Regulatory Authority in such jurisdiction; (c) has one or more Regulatory
Authority-approved Indications in such jurisdiction equivalent to the Regulatory Authority-approved Indication for the Product in such jurisdiction; and (d) is sold in such jurisdiction by a Third Party that is not a Sublicensee of Mundipharma
or its Affiliates, and is not otherwise authorized by Mundipharma or any of its Affiliates, Sublicensees or distributors to sell such product. 
 1.71 “Good Clinical Practices” or “GCP” means the then-current standards, practices and procedures promulgated or endorsed by the FDA as set forth in the guidelines
entitled “Guidance for Industry E6 Good Clinical Practice: Consolidated Guidance,” including related regulatory requirements imposed by the FDA and comparable regulatory standards, practices and procedures promulgated by the EMA or other
Regulatory Authority applicable to the Licensed Territory and/or the Allos Territory, as such standards, practices and procedures may be updated from time to time, including applicable quality guidelines promulgated under the ICH. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 7 

 1.72 “Good Laboratory Practices” or “GLP” means the
then-current good laboratory practice standards promulgated or endorsed by the FDA as defined in 21 C.F.R. Part 58, and comparable regulatory standards promulgated by the EMA or other Regulatory Authority applicable to the Licensed Territory and/or
the Allos Territory, as such standards may be updated from time to time, including applicable quality guidelines promulgated under the ICH. 
 1.73 “Good Manufacturing Practices” or “GMP” means the standards relating to current Good Manufacturing Practices for fine chemicals, API, intermediates, bulk products or
finished pharmaceutical products set forth in (i) 21 U.S.C. 351(a)(2)(B), in FDA regulations at 21 C.F.R. Parts 210 and 211 and in The Rules Governing Medicinal Products in the European Community, Volume IV, Good Manufacturing Practice for
Medicinal Products, or (ii) the ICH Guidelines relating to the manufacture of API and finished pharmaceuticals, as such standards may be updated from time to time, including applicable quality guidelines promulgated under the ICH.

 1.74 “Governmental Authority” means any multi-national, federal, state, local, municipal, provincial or
other governmental authority of any nature (including any governmental division, prefecture, subdivision, department, agency, bureau, branch, office, commission, council, court or other tribunal). 

1.75 “Health Canada” means the Canadian federal government agency responsible for the administration of, inter
alia, the Canada Food and Drugs Act, or any successor agency with responsibilities comparable to those of Health Canada. 
 1.76 “ICH” means the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use. 

1.77 “ICH Guidelines” means the guidelines of the ICH. 

1.78 “Incremental Study” has the meaning set forth in Section 4.4(c)(i). 

1.79 “Indemnified Party” has the meaning set forth in Section 10.4. 

1.80 “Indemnifying Party” has the meaning set forth in Section 10.4. 

1.81 “Indication” means any disease or condition that can be diagnosed or treated. 

1.82 “Information” means any data, results, technology, business or financial information or information of any type
whatsoever, in any tangible or intangible form, including know-how, trade secrets, practices, techniques, methods, processes, inventions, developments, specifications, formulations, formulae, materials or compositions of matter of any type or kind
(patentable or otherwise), software, algorithms, marketing reports, expertise, technology, test data (including pharmacological, biological, chemical, biochemical, clinical test data and data resulting from non-clinical studies), CMC information,
stability data and other study data and procedures. 
 1.82A “Initial Development Plan” has the meaning
set forth in Section 4.2(b). 
 1.83 “Investigator-Sponsored Study” or “ISS” means a
clinical trial on the Product in the Field wherein a Third Party that is not a sublicensee or subcontractor of either Party holds the investigational new drug application or equivalent thereof (if any) for such trial and is solely responsible for
all aspects of the trial, including: trial design; ensuring appropriate institutional and 

  
 8 

 
regulatory approval; conducting such trial, including responsibility for ensuring appropriate medical safeguards, medical monitoring and medical supervision; analysis and interpretation of the
results of such trial; and communication (e.g., publications) of the results of such trial; provided, if either Party has any responsibility for any of the foregoing, then such trial shall not be considered an Investigator-Sponsored Study.

 1.84 “JAMS Rules” has the meaning set forth in Section 13.1. 

1.85 “Japan Milestones” has the meaning set forth in Section 4.6. 

1.86 “Japan Milestone Default Notice” has the meaning set forth in Section 12.4A. 

1.87 “Joint Development Costs” means all costs reasonably incurred by or on behalf of either Party after the Original
Effective Date, including out-of-pocket costs actually incurred by each Party, [***], all as calculated in accordance with U.S. generally accepted accounting principles consistently applied or international financial reporting standards, as
applicable, that are reasonably and directly allocable to such Party’s performance of its obligations under this Agreement with respect to any Shared Study (other than an Allos Study), to the extent that such costs do not exceed [***] of the
budget therefor as specified in the Initial Development Plan; provided, however, “Joint Development Costs” shall specifically exclude (i) all internal costs, and (ii) any and all costs associated with preparing and
filing any and all Regulatory Materials and communicating with any Regulatory Authorities, in each case for the purpose of obtaining and maintaining Regulatory Approval. 
 1.88 “Joint Inventions” has the meaning set forth in Section 8.1. 
 1.89 “Joint Manufacturing Committee” or “JMC” has the meaning set forth in Section 3.2. 
 1.90 “Joint Patents” has the meaning set forth in Section 8.1. 
 1.91 “Joint Product Committee” or “JPC” has the meaning set forth in Section 3.1. 
 1.92 “Knowledge” means, with respect to the Party to which such term is attributed, (i) the actual knowledge of: (a) for Allos: [***]; and (b) for Mundipharma, the
following executives of Mundipharma or its Affiliates: [***], or (ii) the knowledge that any of the foregoing individuals reasonably should have gained through operating in the ordinary course of business with a level of efforts and resources
consistent with the business practices of a similarly sized company with a similarly sized infrastructure to support and carry out its operations. 
 1.93 “Laws” means all laws, statutes, rules, regulations, ordinances and other pronouncements having the effect of law of any federal, national, multinational, state, provincial, county,
city or other political subdivision, domestic or foreign. 
 1.94 “Lead Indication” means the treatment of adult
patients with relapsed or refractory PTCL, where “PTCL” for this purpose is defined by the population included in the “PROPEL” study (PDX-008) or any subset(s) of such population. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 9 

 1.95 “Letter Agreement” means the letter agreement between Allos and
Mundipharma, dated as of the Original Effective Date, in respect of (i) the Initial Development Plan and (ii) Allos’ registered domain names. 
 1.96 “Licensed Marks” has the meaning set forth in Section 8.9(a). 
 1.97 “Licensed Territory” means all countries of the world excluding those in the Allos Territory. 
 1.98 “Licensed Territory Infringement” has the meaning set forth in Section 8.4(a). 
 1.99 “Major Market Countries” means [***]. 
 1.100
“Material Impact” means, with respect to a Party, a material adverse impact on the regulatory status or the commercial sales of the Product in such Party’s applicable territory. 

1.101 “MMCO” means Mundipharma Medical Company, a partnership organized under the laws of Bermuda, and an Affiliate of
Mundipharma. 
 1.102 “Mundipharma-Facilitated ISS” means an ISS that Mundipharma authorizes or facilitates in
accordance with Section 4.7. 
 1.103 “Mundipharma Indemnitees” has the meaning set forth in
Section 10.1. 
 1.104 “Mundipharma ISS Technology” means (a) all Information that (i) is
necessary or useful for the Development or Commercialization of a Product in the Field, (ii) is Controlled by Mundipharma or its Affiliates during the Term, and (iii) arises from a Mundipharma-Facilitated ISS, and (b) any Patent
(other than a Joint Patent) that (x) claims the Product or the API or the manufacture or use in the Field of the Product or the API, (y) is Controlled by Mundipharma or its Affiliates during the Term, and (z) claims an invention
arising from a Mundipharma-Facilitated ISS; provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Mundipharma after the Effective Date due to a Change of Control of Mundipharma,
except to the extent such Third Party’s Information or Patents are Controlled by Mundipharma (or its Acquiror) or any of its other Affiliates and are necessary for the Development or Commercialization of the Product and are utilized in respect
of the Product or the API in the Licensed Territory. 
 1.105 “Mundipharma Know-How” means all Information that
(a) is necessary or useful for the Development or Commercialization of a Product in the Field and (b) is Controlled by Mundipharma or its Affiliates during the Term and arises from a Shared Study (including any Incremental Study that
becomes an Additional Study upon Allos’ exercise of the Opt-In Right under Section 4.4(c)(v)); provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Mundipharma after the
Original Effective Date due to a Change of Control of Mundipharma, except to the extent such Third Party’s Information is Controlled by Mundipharma (or its Acquiror) or any of its other Affiliates and is necessary for the Development or
Commercialization of the Product and is utilized in respect of the Product or the API in the Licensed Territory; and provided further that “Mundipharma Know-How” excludes Information arising from any Incremental Study (with respect to
which Allos does not exercise its Opt-In Right under Section 4.4(c)(v)) or Investigator-Sponsored Study. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 10 

 1.106 “Mundipharma Patent” means any Patent (other than a Joint Patent)
that (a) claims the Product or the API or the manufacture or use in the Field of the Product or the API and (b) is Controlled by Mundipharma or its Affiliates during the Term and claims an invention arising from a Shared Study (including
any Incremental Study that becomes an Additional Study upon Allos’ exercise of the Opt-In Right under Section 4.4(c)(v)); provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate
of Mundipharma after the Original Effective Date due to a Change of Control of Mundipharma, except to the extent such Third Party’s Patents are Controlled by Mundipharma (or its Acquiror) or any of its other Affiliates and are necessary for the
Development or Commercialization of the Product and are utilized in respect of the Product or the API in the Licensed Territory; and provided further that “Mundipharma Patent” excludes any Patent that claims an invention arising from any
Incremental Study (with respect to which Allos does not exercise its Opt-In Right under Section 4.4(c)(v)) or Investigator-Sponsored Study. 
 1.107 “Mundipharma Payment-Allos Withholding Tax Action” has the meaning set forth in Section 7.10(c)(ii). 
 1.108 “Mundipharma Payment-Mundipharma Withholding Tax Action” has the meaning set forth in Section 7.10(c)(i). 

1.109 “Mundipharma Share” means forty percent (40%). 

1.110 “Mundipharma Sublicense Agreement” has the meaning set forth in Section 2.1(f)(ii). 

1.111 “Mundipharma Technology” means the Mundipharma Know-How, Mundipharma Patents and Mundipharma’s interest in
Joint Patents. 
 1.111A “Mundipharma Total Switzerland Costs” means the actual out-of-pocket and FTE costs and
expenses incurred by Mundipharma in connection with registering and maintaining any Regulatory Approvals for the Product in the Field in Switzerland. 
 1.112 “Net Sales” means, with respect to any Product, the total amount invoiced by Mundipharma, its Affiliates or Sublicensees to each Third Party receiving Product in an arms length
transaction, less: (a) [***]; (b) [***]; (c) [***]; and (d) [***]. 
 For purposes of this definition of “Net
Sales”, if Mundipharma, its Affiliate or sublicensee sells a Product in the form of a combination product containing one or more active ingredients in addition to Product, “Net Sales” for such combination product will be calculated by
multiplying actual Net Sales thereof by the fraction A/(A+B) where A is the invoice price of the Product if sold separately, and B is the total invoice price of the other active ingredient or ingredients in the combination, if sold separately. If,
on a country-by-country basis, the other active ingredient or ingredients in the combination are not sold separately in said country, “Net Sales” shall be calculated by multiplying 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 11 

 
actual Net Sales thereof by the fraction A/C where A is the invoice price of the Product if sold separately, and C is the invoice price of the combination product. If, on a country-by-country
basis, the Product is not sold separately in said country, “Net Sales” shall be determined by the Parties in good faith on the basis of the fair market value of the Product. With respect to any transfer of any Product in a given country
for any substantive consideration other than monetary consideration on arms length terms, for purposes of calculating “Net Sales” under this Agreement, such Product shall be deemed to be sold exclusively for money at the average Net Sales
price charged to Third Parties for cash sales in such country during the applicable reporting period (or if there were only de minimus cash sales in such country, at the fair market value as determined by comparable markets). 

1.113 “New Compound” means (i) any active pharmaceutical ingredient other than the API, or (ii) any
pharmaceutical product containing an active pharmaceutical ingredient other than the API (excluding any combination product containing the API). 
 1.114 “New Form” means a form of API (as defined in this Agreement) or Product that is different from API (as defined in the Supply Agreement) or Bulk Product, respectively. 

1.115 “Non-Breaching Party” has the meaning set forth in Section 12.2. 

1.116 “Non-Conducting Party” has the meaning set forth in Section 4.4(c)(i). 

1.117 “Non-Governmental Authority” means any public body (including the National Institute of Clinical Excellence and the
Scottish Medicines Consortium in the U.K.; the Institute for Quality and Efficiency in Healthcare in Germany; the Technical Scientific Commission in Italy; the Directorate of Pharmacy and Healthcare Products in Spain; and the National Union of
Health Insurance Funds and the National Authority of Health in France) or non-Governmental Authority (including “Sick Funds” in Germany) with the authority to control, approve, recommend or otherwise determine pricing and reimbursement of
pharmaceutical products, including those with authority to enter into risk sharing schemes and/or to impose retroactive price reductions, discounts, or rebates. 
 1.118 “Non-Oncology Indication” means any Indication that is not an Oncology Indication. 
 1.119 “Oncology Indication” means any Indication in the field of oncology, as defined by the American Cancer Society, including all Indications listed in Exhibit A. 

1.120 “Opt-In Estimate” has the meaning set forth in Section 4.4(c)(v). 

1.121 “Opt-In Option Date” has the meaning set forth in Section 4.4(c)(v). 

1.122 “Opt-In Payment” has the meaning set forth in Section 4.4(c)(v). 

1.123 “Opt-In Right” has the meaning set forth in Section 4.4(c)(v). 

1.123A “Original Effective Date” means May 10, 2011. 

1.124 “Other Committees” has the meaning set forth in Section 3.1(a)(xvi). 

  
 12 

 1.125 “Patents” means (a) pending patent applications, issued patents,
utility models and designs; (b) reissues, substitutions, confirmations, registrations, validations, re-examinations, additions, continuations, continued prosecution applications, continuations-in-part, or divisions of or to any of the
foregoing; (c) any other patent application claiming priority to any of the foregoing anywhere in the world; and (d) extension, renewal or restoration of any of the foregoing by existing or future extension, renewal or restoration
mechanisms, including supplementary protection certificates or the equivalent thereof. 
 1.126 “Payee” has the
meaning set forth in Section 7.7. 
 1.127 “PDX Breach” has the meaning set forth in
Section 12.4(c)(i). 
 1.128 “PDX License Agreement” means the License Agreement dated as of
December 23, 2002 by and among Allos, SRI International, Sloan-Kettering Institute for Cancer Research and Southern Research Institute, as amended. 
 1.129 “PDX Licensor” means, collectively, SRI International, Sloan-Kettering Institute for Cancer Research and Southern Research Institute, and any successors thereto. 

1.130 “PDX Patents” means the Allos Patents licensed by Allos from the PDX Licensor under the PDX License Agreement,
which Patents in existence on the Original Effective Date are shown in Schedule 1 with the PDX Licensor listed as the “Registered Proprietor”. 
 1.131 “Pediatric Studies” has the meaning set forth in Section 4.2(b). 
 1.132 “Percentage Market Penetration” means the percentage obtained by dividing [***] by the [***]. 
 1.133 “Percentage Price Reduction” means the percentage by which [***] is reduced, as compared to the [***], as a result of (x) [***] or (y) [***]. 

1.134 “Pharmacovigilance Agreement” has the meaning set forth in Section 5.7. 

1.135 “Phase 1 Study” means a human clinical trial of the Product with the endpoint of determining initial tolerance,
safety or pharmacokinetic information in single dose, single ascending dose, multiple dose and/or multiple ascending dose regimens, as described in 21 C.F.R. § 312.21(a) (or its successor regulation) or the equivalent thereof in any
jurisdiction outside the U.S. 
 1.136 “Phase 2 Study” means a human clinical trial of the Product, the
principal purpose of which is a preliminary determination of safety and efficacy in the target patient population over a range of doses and dose regimens, as described in 21 C.F.R. § 312.21(b) (or its successor regulation) or the equivalent
thereof in any jurisdiction outside the U.S. 
 1.137 “Pricing Approval” means the governmental approval,
agreement, determination or decision establishing prices for the Product that can be charged in regulatory jurisdictions where the applicable Governmental Authorities approve or determine the price of pharmaceutical products. 

1.138 “Primary Agreement” has the meaning set forth in Section 9.2(u). 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 13 

 1.139 “Product” means any pharmaceutical product containing the API, [***],
or any improvement made by Allos or Mundipharma to the API, [***] developed by Allos or Mundipharma pursuant to the terms of this Agreement; provided, however, that notwithstanding the foregoing, except as provided in
Section 9.4(m), Mundipharma shall have no rights or licenses under this Agreement in or to any New Compound that is Controlled by Allos or its Affiliates. 
 1.140 “Proposed Study” has the meaning set forth in Section 4.4(a). 
 1.141 “PSURs” has the meaning set forth in Section 5.1(b). 

1.142 “PTCL” means peripheral T-cell lymphoma. 
 1.143 “Publication” has the meaning set forth in Section 11.3. 
 1.144 “Reasonably Diligent Efforts” means, with respect to a Party’s obligations under this Agreement, the carrying out of such obligations with a level of efforts and resources
consistent with the commercially reasonable practices of a similarly sized company [***]; provided, “Reasonably Diligent Efforts” shall (i) [***]; and (ii) require that the Party: (a) [***], (b) [***]; and provided
further, that “Reasonably Diligent Efforts” (i) with respect to [***], requires that [***], or (ii) [***]. 

1.145 “Regulatory Approval” means (i) Drug Approval and all other approvals necessary for the commercial sale of the
Product in a given country or regulatory jurisdiction; (ii) Pricing Approval (but only in those countries or regulatory jurisdictions where Pricing Approval is required by applicable Law for commercial sale); and (iii) Reimbursement
Approval, but only in those countries or regulatory jurisdictions where Reimbursement Approval is required for the price paid for the Product to be reimbursed by a Governmental Authority or a Non-Governmental Authority with the authority to approve
reimbursement. 
 1.146 “Regulatory Authority” means, in a particular country or jurisdiction, any applicable
Governmental Authority or Non-Governmental Authority involved in granting Regulatory Approval in such country or jurisdiction. 

1.147 “Regulatory Materials” means regulatory applications, submissions, notifications, communications, correspondence,
registrations, drug approvals and/or other filings made to, received from or otherwise conducted with a Regulatory Authority in order to Develop, manufacture, market, sell or otherwise Commercialize the Product in a particular country or
jurisdiction. 
 1.148 “Regulatory Plan” means a plan regarding the timing and approach to preparing, submitting
or reviewing Regulatory Materials and obtaining and maintaining Drug Approval in the Licensed Territory. 
 1.149
“Reimbursement Approval” means the approval, agreement, determination or decision recommending or approving the Product for use and/or establishing the prices for the Product that can be reimbursed in regulatory jurisdictions where the
applicable Governmental Authority or Non-Governmental Authority approves, determines or recommends the reimbursement or use of pharmaceutical products. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 14 

 1.150 “Related Study” has the meaning set forth in Section 4.4(d).

 1.151 “Remedial Action” has the meaning set forth in Section 5.8. 

1.151A “Required Additional Study Election” has the meaning set forth in Section 5.2(d). 

1.152 “Royalty Term” has the meaning set forth in Section 7.4(b). 

1.153 “Safety Reason” has the meaning set forth in Section 13.2(a). 

1.154 “SEC” has the meaning set forth in Section 11.4(d). 

1.155 Omitted. 
 1.156 Omitted. 
 1.157 “Second Confidentiality
Agreement” means the confidentiality agreement between Allos and Mundipharma Pharmaceuticals Inc. dated [***]. 

1.158 “Second Letter Agreement” means the letter agreement between Allos and Mundipharma, dated [***]. 

1.159 Omitted. 
 1.160 Omitted. 
 1.161 “Shared Claims” has the
meaning set forth in Section 10.3. 
 1.162 “Shared Costs” has the meaning set forth in Section 10.3.

 1.163 “Shared Study” means any of the Existing Studies (including Allos Studies and Pediatric Studies) or
Additional Studies. 
 1.164 “Sole Inventions” has the meaning set forth in Section 8.1. 

1.165 “Sublicense Revenue” means [***], but excluding sums received: (a) [***], (b) [***]; (c) [***];
(d) [***]; (e) [***]; (f) [***]; or (g) [***]; provided, however, [***], then for purposes of calculating Sublicense Revenue arising from [***]. 

1.166 “Sublicensee” has the meaning set forth in Section 2.1(f)(ii). 

1.167 “Supply Agreement” has the meaning set forth in the Recitals. 

1.167A “Switzerland Option” has the meaning set forth in Section 14.17. 

1.168 “Technical Agreement” has the meaning set forth in the Supply Agreement. 

1.169 “Term” has the meaning set forth in Section 12.1. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 15 

 1.170 “Third Party” means any entity other than Allos or Mundipharma or an
Affiliate of either of them. 
 1.171 “Third Party Claim” has the meaning set forth in Section 8.7.

 1.172 “Transferred Countries” has the meaning set forth in Section 14.16. 

1.173 “Transition Date” means [***]. 
 1.174 “U.S.” means the United States of America, including all possessions and territories thereof. 
 ARTICLE 2 
 LICENSES 

2.1 Licenses to Mundipharma. 
 (a) Development License to Mundipharma. Subject to the terms and conditions of this Agreement, Allos hereby grants to Mundipharma an exclusive (even as to Allos except as provided in
Section 2.1(e)), milestone-bearing right and license, with the right to sublicense solely as provided in Section 2.1(f), under the Allos Technology and the Allos ISS Technology, to Develop the Product in the Field in accordance with the
Development Plan and for the purpose of obtaining or maintaining Regulatory Approvals in the Field in the Licensed Territory or otherwise exercising Mundipharma’s rights or performing Mundipharma’s obligations under the Development Plan
(including for the purpose of conducting any Additional Study pursuant to Section 4.4(a) or (b) or proceeding with an Incremental Study pursuant to Section 4.4(c) in the Licensed Territory or the Allos Territory). For clarity, the
foregoing license does not include a right for Mundipharma to manufacture or have manufactured Products for use in Development, and Mundipharma’s and its designees’ only rights under the Allos Technology to manufacture or have
manufactured Products are as expressly set forth in Section 2.1(c) and in the Supply Agreement. For further clarity, the foregoing license does not include a right for Mundipharma to make or have made any derivatives of the API. If
Mundipharma wishes to make any such derivatives, it shall inform Allos in writing and shall refrain from making or having made any such derivatives of the API unless and until it receives Allos’ prior written consent. 

(b) Commercial License to Mundipharma. Subject to the terms and conditions of this Agreement, Allos hereby grants to Mundipharma an
exclusive (even as to Allos except as provided in Section 2.1(e)), milestone- and royalty-bearing right and license, with the right to sublicense solely as provided in Section 2.1(f), under the Allos Technology and the Allos ISS
Technology, to use, sell, offer for sale, import, export, distribute, warehouse, market, promote, apply for and submit applications for Pricing Approval and Reimbursement Approval, and otherwise Commercialize Products in the Field in the Licensed
Territory. For clarity, the foregoing license does not include a right for Mundipharma to manufacture or have manufactured Products for use in Commercialization, and Mundipharma’s and its designees’ only rights under the Allos
Technology to manufacture or have manufactured Products are as expressly set forth in Section 2.1(c) and in the Supply Agreement. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 16 

 (c) Manufacturing Licenses. 

(i) With Respect to Bulk Product. Subject to the terms and conditions of this Agreement and the Supply Agreement,
Allos hereby grants to Mundipharma a non-exclusive, royalty-free limited right and license, with the right to sublicense in accordance with Section 2.1(f) to its Affiliates or, with the prior written consent of Allos to a Third Party
manufacturer (which consent shall not be unreasonably withheld, conditioned or delayed; provided, however, that with respect to a sublicense to the Current Third Party Manufacturer of Bulk Product, the terms of Section 2.1(f)(i)
shall govern), under the Allos Manufacturing Know-How and Allos Patents, to manufacture Bulk Product solely for use in accordance with this Agreement. 
 (ii) With Respect to API (as defined in the Supply Agreement). Subject to the terms and conditions of this Agreement and the Supply Agreement, Allos hereby grants to Mundipharma a
non-exclusive, royalty-free limited right and license, with the right to sublicense in accordance with Section 2.1(f) to its Affiliates or, with the prior written consent of Allos to a Third Party manufacturer (which consent shall not be
unreasonably withheld, conditioned or delayed; provided, however, that with respect to a sublicense to the Current Third Party Manufacturers of API (as defined in the Supply Agreement), the terms of Section 2.1(f)(i) shall
govern), under the Allos Manufacturing Know-How and Allos Patents, to manufacture API (as defined in the Supply Agreement) solely for use in non-clinical studies in accordance with this Agreement and for use by Mundipharma or its Affiliates or
permitted Third Party manufacturers in manufacturing Bulk Product in accordance with Section 2.1(c)(i). 
 (d) PDX
License Agreement. The licenses granted to Mundipharma in Sections 2.1(a), 2.1(b) and 2.1(c) include sublicenses under Allos Technology licensed to Allos under the PDX License Agreement. The licenses granted to Mundipharma in
Sections 2.1(a), 2.1(b) and 2.1(c) are subject to the license rights and restrictions associated with such rights under the PDX License Agreement, in each case to the extent applicable to the rights granted to Mundipharma hereunder. 

(e) Allos Retained Rights. Notwithstanding the exclusive rights granted to Mundipharma in Sections 2.1(a) and 2.1(b)
and without limiting the generality of Section 2.4, Allos retains the right to practice the Allos Technology to: (i) Develop the Product in the Field in accordance with the Allos Required Studies Schedule and for the purpose of exercising
Allos’ rights or performing Allos’ obligations under the Allos Required Studies Schedule (including for the purpose of conducting any Additional Study pursuant to Section 4.4(a) or (b) or proceeding with an Incremental Study
pursuant to Section 4.4(c)) in the Licensed Territory or the Allos Territory; (ii) Develop the Product for the purpose of obtaining or maintaining Regulatory Approval in the Allos Territory; (iii) use, sell, offer for sale, import,
export, distribute, warehouse, market, promote, apply for and submit applications for Pricing Approval and Reimbursement Approval, and otherwise Commercialize Products in the Field in the Allos Territory; (iv) manufacture or have manufactured
Products anywhere in the world; and (v) practice and license the Allos Technology in the Field in the Allos Territory. 

  
 17 

 (f) Sublicense Rights. 

(i) Mundipharma shall have the right to grant sublicenses (i) of the licenses granted in Sections 2.1(a), 2.1(b) and 2.1(c)
or (ii) to sell Products in the Licensed Territory in the Field, in each case without the prior approval of Allos, only to (A) its Affiliates, provided that such sublicense shall automatically terminate if such person, corporation,
partnership or entity ceases to be an Affiliate of Mundipharma, and (B) Third Party subcontractors that are performing part of Mundipharma’s obligations under this Agreement (excluding any Third Party manufacturers), and in each case
provided that Mundipharma shall at all times sell, offer for sale, import, export and otherwise Commercialize the Product in Mundipharma’s or its Affiliate’s name. Mundipharma shall not grant any sublicenses (i) of the licenses
granted in Sections 2.1(a), 2.1(b) and 2.1(c), or (ii) any rights to sell the Product in the Field in the Licensed Territory, to any Third Party (including any Third Party manufacturer but excluding any non-manufacturing Third Party
subcontractors as permitted in the preceding sentence) without the prior approval of Allos, which approval shall not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, the Parties agree it would be reasonable for Allos
to withhold consent [***], unless, at the time such consent is requested, (i) [***], and (ii) [***]. Mundipharma shall be solely responsible for all of its Sublicensees’, subcontractors’, agents’ and distributors’
activities and any and all failures by its Sublicensees, subcontractors, agents or distributors to comply with the terms of this Agreement. 
 (ii) Mundipharma shall, within [***] after granting any sublicense under Sections 2.1(a), 2.1(b) or 2.1(c) above, or rights to sell the Product in the Field in the Licensed Territory to a Third
Party, notify Allos of the grant of such sublicense to a Third Party and provide Allos with a true and complete copy of the agreement (a “Mundipharma Sublicense Agreement”) between Mundipharma and such Third Party (the
“Sublicensee”), pursuant to which such sublicense or rights were granted. Each Mundipharma Sublicense Agreement shall be consistent with the terms and conditions of this Agreement and shall include the following additional terms and
conditions: 
 (A) No Mundipharma Sublicense Agreement shall obligate (or purport to obligate) Allos without Allos’
express written consent; 
 (B) the Sublicensee shall provide Mundipharma with all Information, Regulatory Materials and
other documentation necessary for Mundipharma to comply with its obligations under this Agreement, including payment and reporting obligations hereunder, and shall include audit provisions substantially similar to those contained in this Agreement;

 (C) the Sublicensee shall be bound by non-use and non-disclosure obligations no less stringent than those set forth in
this Agreement; 
 (D) the Sublicensee shall not have any right to grant sublicenses to the Allos Technology or the
Mundipharma Technology; 
 (E) the Sublicensee shall not have any right to prosecute or maintain any Allos Patents, Joint
Patents or Mundipharma Patents; and 

  
 [***]: CONFIDENTIAL
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 18 

 (F) Mundipharma or, with prior written notice to Allos, its designated Affiliate
shall own and Control all Information and Patents relating to the Product or the API made and all Regulatory Materials prepared or filed by the Sublicensee in the course of conducting its activities under the Mundipharma Sublicense Agreement. Such
designated Affiliate of Mundipharma shall be subject to all applicable covenants, obligations, representations and warranties of Mundipharma under this Agreement. 
 (iii) With respect to any Mundipharma Sublicense Agreement that includes a sublicense under Allos Technology licensed to Allos under the PDX License Agreement: 

(A) Allos shall be permitted to provide SRI International, Sloan-Kettering Institute for Cancer Research and Southern Research
Institute, with a copy of such Mundipharma Sublicense Agreement; and 
 (B) the Sublicensee’s rights shall be
subject to the license rights and restrictions associated with such rights under the PDX License Agreement, in each case to the extent applicable to the rights granted to the Sublicensee. 

(iv) Mundipharma shall pay to Allos [***] of all Sublicense Revenue within [***] after the end of the calendar quarter in which
Mundipharma receives such Sublicense Revenue from a Third Party. 
 (g) Limited Incremental Study License to
Mundipharma. Subject to the terms and conditions of this Agreement, Allos hereby grants to Mundipharma a non-exclusive, fully paid, royalty-free limited right and license under any Patent Controlled by Allos during the Term that
claims the Product or the API or the manufacture or use in the Field of the Product or the API (other than an Allos Patent, Joint Patent or Patent within the Allos ISS Technology), to the extent necessary for the Development of Product in accordance
with the Development Plan (in the Allos Territory or the Licensed Territory) or for the Commercialization of the Product in the Field in the Licensed Territory. 
 2.2 License to Allos. 
 (a) Subject to the terms and
conditions of this Agreement, Mundipharma hereby grants to Allos (i) a co-exclusive, fully paid, royalty-free right and license (with the right to grant sublicenses) under the Mundipharma Technology and the Mundipharma ISS Technology, to
Develop Products in the Field in accordance with the Allos Required Studies Schedule or to otherwise exercise Allos’ rights or perform Allos’ obligations under the Allos Required Studies Schedule (including for the purpose of conducting
any Additional Study pursuant to Section 4.4(a) or (b) or proceeding with an Incremental Study pursuant to Section 4.4(c) in the Licensed Territory or the Allos Territory); and (ii) an exclusive (even as to Mundipharma), fully
paid, royalty-free right and license (with the right to grant sublicenses), under the Mundipharma Technology and the Mundipharma ISS Technology, to (A) Develop Products in the Field for the purpose of obtaining or maintaining Regulatory
Approval in the Allos Territory, and (B) use, sell, offer for sale, import, distribute, warehouse, market, promote, apply for and submit applications for Pricing Approval and Reimbursement Approval, and otherwise Commercialize Products in the
Field in the Allos Territory.  

  
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Notwithstanding the exclusive rights granted to Allos in this Section 2.2 and without limiting the generality of Section 2.4, Mundipharma retains the right to practice the Mundipharma
Technology for the purpose of performing Mundipharma’s obligations with respect to Shared Studies. 
 (b) Limited
Incremental Study License to Allos. Subject to the terms and conditions of this Agreement, Mundipharma hereby grants to Allos a non-exclusive, fully paid, royalty-free limited right and license under any Patent Controlled by Mundipharma that
claims the Product or the API or the manufacture or use in the Field of the Product or the API (other than a Mundipharma Patent, Joint Patent or Patent within the Mundipharma ISS Technology) to the extent necessary for the Development of Product in
accordance with the Allos Required Studies Schedule (in the Allos Territory or the Licensed Territory) or for the Commercialization of the Product in the Field in the Allos Territory. 

(c) Manufacturing License to Allos. Subject to the terms and conditions of this Agreement, Mundipharma hereby grants to Allos a
non-exclusive, fully paid, royalty-free, irrevocable limited right and license (with the right to grant sublicenses), under Information or inventions made, conceived, obtained or generated by or on behalf of Mundipharma or any of its Affiliates or
Third Party manufacturers in the course of manufacturing Product or API or any components thereof and any Patents claiming such Information or invention, to manufacture and have manufactured API and Product. Mundipharma shall use reasonable best
efforts to promptly disclose to Allos all Information and inventions made, conceived, obtained or generated by or on behalf of Mundipharma or any of its Affiliates or Third Party manufacturers in the course of manufacturing Product or API or any
components thereof. 
 2.3 Negative Covenant. Mundipharma covenants that it will not, and will not permit any of
its Affiliates or Sublicensees to, use or practice any Allos Technology or Allos ISS Technology outside the scope of the licenses granted to it under Sections 2.1(a), 2.1(b) and 2.1(c). Allos covenants that it will not, and will not permit any of
its Affiliates or sublicensees to, use or practice any Mundipharma Technology or Mundipharma ISS Technology outside the scope of the licenses granted to it under Section 2.2. 

2.4 No Implied Licenses. Except as explicitly set forth in this Agreement, neither Party shall be deemed by estoppel or implication
to have granted the other Party any license or other right to any intellectual property of such Party. 
 ARTICLE 3

 GOVERNANCE 
 3.1 Joint Product Committee. 
 (a) Formation and Role. Within
[***] after the Effective Date, the Parties will establish a joint product committee (the “Joint Product Committee” or “JPC”) for the overall oversight and coordination of the Parties’ activities under this
Agreement and for overseeing (i) the Development of the Product in the Field in the Licensed Territory, and (ii) the Commercialization of the Product in the Field in the Licensed Territory. The role of the JPC shall be: 

  
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 (i) to review, discuss and approve the overall strategy for the Development and Drug
Approval of the Product in the Field in the Licensed Territory; 
 (ii) to review and discuss the overall performance of
the Parties pursuant to this Agreement and to compare performance of the objectives outlined in the Development Plan and the Allos Required Studies Schedule to the diligence obligations set forth in Sections 4.6 and 5.2(d); 

(iii) to oversee the Development of the Product in the Field in the Licensed Territory; 

(iv) to review, discuss, prepare and approve amendments to the Development Plan, including the budget for each Development
activity and the design of each clinical trial or other study included or proposed to be included in the Development Plan pursuant to Section 4.4, and to review, discuss, prepare and approve amendments to the Regulatory Plan; 

(v) to agree on the requirements for Drug Approval and review and discuss overall strategy for Pricing Approval and Reimbursement
Approval of the Product in the Field in the Licensed Territory; 
 (vi) to establish general guidelines for
Investigator-Sponsored Studies with respect to a Product in the Field which, if complied with by a particular ISS, will allow a Party to authorize or facilitate such ISS on prior notice to the JPC but without the need for obtaining the other
Party’s approval; 
 (vii) to review any disputes between the Parties regarding a potential Material Impact of an
ISS that does not comply with the general guidelines established by the JPC; 
 (viii) to discuss the Parties’
activities with respect to the Product in the Field in the Licensed Territory in conjunction with Allos’ and its licensees’ activities with respect to the Product in the Field in the Allos Territory; 

(ix) to review, discuss and coordinate the Parties’ scientific presentation and publication strategy relating to Products in
the Field in the Licensed Territory; 
 (x) to discuss the Parties’ respective Development activities in the Field
as between the Licensed Territory and the Allos Territory, including Incremental Studies; 
 (xi) to review and discuss
the Commercialization Plan, as well as any amendments thereto; 
 (xii) to discuss the Parties’ respective
Commercialization activities in and as between the Licensed Territory and the Allos Territory; 
 (xiii) to oversee
implementation of the Commercialization Plan; 
 (xiv) to review any [***] after receipt of Regulatory Approval;

  
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 (xv) to review, discuss and coordinate the Parties’ attendance, Product
messaging and presentations (including “poster-board” presentations and industry booths) at international seminars and conferences at which the Product is being discussed; 

(xvi) to direct and oversee the JMC and any other operating committee (the “Other Committees”) established by the
JPC, on all significant issues that fall within the purview of such committees; 
 (xvii) to appoint Other
Committees, consisting of equal numbers of appropriately qualified members appointed by each Party, from time to time as it deems fit; 
 (xviii) to attempt to resolve, in a timely manner, issues presented to it by, and disputes within, the JMC and Other Committees; 

(xix) to facilitate the flow of Information between the Parties with respect to the Development of, obtaining Drug Approval for,
and the Commercialization of, Products in the Field; and 
 (xx) perform such other functions as appropriate to
further the purposes of this Agreement, as expressly set forth in this Agreement or as mutually determined by the Parties in writing. 
 The JPC shall have only the powers expressly assigned to it in this Section 3.1 and elsewhere in this Agreement. The JPC shall have no power to interpret, amend, modify, or waive compliance with this
Agreement. 
 (b) Members. Each Party shall initially appoint two (2) representatives to the JPC, each of whom will
be an officer or employee of such Party having sufficient seniority within the applicable Party to make decisions arising within the scope of the JPC’s responsibilities. The JPC may change its size from time to time by mutual consent of its
members and each Party may replace its representatives at any time upon written notice to the other Party; provided, however, that the JPC will at all times consist of equal numbers of members appointed by each Party. In the event a
JPC representative from either Party is unable to attend or participate in a meeting of the JPC, the Party who designated such representative may designate an appropriately qualified substitute representative for the meeting, in its sole discretion.
The JPC shall have a chairperson, who shall be elected, on an annual basis, alternatively by Allos or Mundipharma. The initial chairperson shall be selected by Allos. The role of the chairperson shall be to convene and preside at all meetings of the
JPC and to ensure the preparation of meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by other JPC representatives. 
 (c) Meetings. The JPC shall meet at least two (2) times per calendar year during the Term unless the Parties mutually agree in writing to a different frequency for such meetings. Either Party
may also call a special meeting of the JPC (by videoconference or teleconference) upon at least [***] prior written notice to the other Party in the event such Party reasonably believes that a significant matter must be addressed prior to the next
regularly scheduled meeting, and such Party shall provide the JPC no later than [***] prior to the special meeting with materials reasonably 

  
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adequate to enable an informed decision to be made by its members. The JPC may meet in person, by videoconference or by teleconference. Each Party shall be responsible for its own expenses
relating to such meetings. As appropriate, other employee representatives or agents of the Parties may attend JPC meetings as non-voting observers and/or presenters. The chairperson of the JPC shall be responsible for preparing reasonably detailed
written minutes of all JPC meetings that reflect and include all material decisions made at such meetings. The JPC chairperson shall send draft meeting minutes to each member of the JPC for review and approval within ten (10) business days
after each JPC meeting. Such minutes shall be deemed approved unless one or more members of the JPC objects to the accuracy of such minutes within ten (10) business days of receipt. 

(d) Decision Making. Actions to be taken by the JPC shall be taken only following unanimous vote, with each Party having one
(1) vote representing the views of its members. If the JPC fails to reach unanimous agreement on a matter before it for decision for a period in excess of [***], either Party may submit the matter in writing to the other, and the Parties shall
refer such dispute to the Chief Executive Officer or other designee of Allos and the General Manager of Mundipharma (or their respective designees) (the “Executive Officers”) for resolution in accordance with the decision-making
procedures described in Section 13.2; provided, however, that the following disputes shall not be submitted to the Executive Officers for resolution and instead shall be decided as follows: (i) for any dispute regarding
[***], the JPC members for [***]; (ii) for any dispute regarding the [***], the JPC members for [***]; (iii) for any dispute regarding [***], the JPC members for [***]; and (iv) for any dispute regarding [***]. 

3.2 Joint Manufacturing Committee. A joint manufacturing committee (the “Joint Manufacturing Committee” or
“JMC”) will be established pursuant to the Supply Agreement. The roles and responsibilities of the JMC shall be as specified in the Supply Agreement. 
 3.3 Good Faith. In conducting themselves on any committees, all representatives of both Parties shall consider diligently, reasonably and in good faith all input received from the other Party, and
shall use Reasonably Diligent Efforts to reach consensus on all matters before them. In exercising any decision-making authority granted to it under this Article 3, each Party shall conduct its discussions in good faith. Notwithstanding anything to
the contrary in this Agreement, neither Party nor any of their respective Affiliates shall be required to take, or shall be penalized for not taking, any action that is not in compliance with such Party’s ethical business practices and policies
or that such Party reasonably believes is not in compliance with applicable Laws. 
 3.4 Scope of Governance. The Parties
agree not to share or discuss any strategic or commercially sensitive information beyond the scope of the collaboration contemplated by this Agreement. 
 ARTICLE 4 
 PRODUCT DEVELOPMENT 

4.1 Overview. The Parties desire and intend to collaborate with respect to the Development of the Product in the Field, as and to
the extent set forth in this Agreement. As described in more detail in this Article 4 (with respect to the non-clinical and clinical aspects of 

  
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Development) and Article 5 (with respect to the regulatory aspects of Development), the Parties have already agreed that certain Development activities for the Product in the Field, up to and
including the Effective Date, pursuant to the Original Agreement, were to be jointly funded and others were to be solely funded by Allos. The Parties have also agreed upon a mechanism for proposing new studies in the Field and determining whether
the Parties wish to jointly fund such studies or if one of the Parties may conduct such study without funding from the other Party. 
 4.2 Development Plan. 
 (a) General. Development of the
Product with respect to the Field shall be conducted pursuant to a comprehensive written development plan (the “Development Plan”), which shall specify all Development activities for the Product in the Field by Mundipharma,
regardless of whether such activities are jointly funded by the Parties or funded by just one of the Parties, and shall include a detailed timeline for performing those activities necessary to obtain Regulatory Approval in the Field in each country
in the Licensed Territory (such timeline, the “Regulatory Plan”). For each Development activity specified in the Development Plan, the Development Plan shall specify the timeline for initiating and completing such activity, and the
budget for such activity. For each clinical trial specified in the Development Plan, the Development Plan shall specify the planned accrual for such trial, the sites at which the trial will be conducted and the lead investigator(s) for such trial.
For clarity, the Initial Development Plan and the Amended Development Plan shall each be considered iterations of the Development Plan, it being understood that neither party shall be obligated to perform trials and/or studies set forth in the
Initial Development Plan that are not included in the Amended Development Plan or the Allos Required Studies Schedule. 

(b) Initial Development Plan; Amended Development Plan. The Parties agreed upon an initial development plan, which was set forth in
the Letter Agreement (the “Initial Development Plan”). The studies set forth in Exhibit 1 to the Initial Development Plan, as amended from time to time (the “Existing Studies”) included: (i) studies that
were being conducted by or on behalf of Allos as of the Original Effective Date; (ii) activities that had not been initiated as of the Original Effective Date but were needed to generate Information that was required by the FDA as a condition
of the Product’s Regulatory Approval in the U.S. for the Lead Indication; (iii) certain medical affairs, and clinical and non-clinical studies that were identified in Exhibit 1 to the Initial Development Plan, as amended from time
to time, as “Allos Studies”; and (iv) those pediatric studies (and associated preclinical and CMC requirements) required by the EMA with respect to the Product in the Field (the “Pediatric Studies”). The
Initial Development Plan identified the Party with operational responsibility for the activities that formed a part of the Existing Studies. Each Party shall be responsible for such Party’s share (i.e., the Allos Share or the Mundipharma Share,
as applicable) of the costs associated with the Existing Studies incurred before the Transition Date, pursuant to the Original Agreement, except that Allos shall be solely responsible for all costs incurred before the Transition Date, pursuant to
the Original Agreement, with respect to the conduct of all Allos Studies. After the Transition Date, (i) no Development activities for the Product in the Field will be jointly funded (except for an Additional Study pursuant to
Section 4.4(b)), (ii) the cost of the Existing Studies (including any Existing Study relating to First Line PTCL Indications) will be solely funded by Allos, (iii) any Development activities for the Product in the Field in the
Licensed Territory conducted by Mundipharma will be solely funded by Mundipharma (except for an Additional Study pursuant to Section 4.4(b)), and (iv) any Incremental Studies pursuant to Section 4.4(c) shall be borne by the Party
conducting such study. For clarity, after the Transition Date, (i) neither Party shall have any Joint Development Cost payment obligations to the other Party, except as set forth in Section 7.2, and (ii) each Party, in addition to the
Development activities 

  
 24 

 
referenced in subsection (iii) of this Section 4.2(b), shall continue to rely on its right of access to data pursuant to Section 4.8, and right of reference to Regulatory Materials
pursuant to Section 5.4, for the purpose of Developing and Commercializing the Product in the Field in such Party’s territory. In connection with this amendment and restatement of the Original Agreement, the Parties have agreed upon an
amended Development Plan, which is set forth in the Second Letter Agreement (the “Amended Development Plan”). 

(c) Amendments. The JPC shall periodically review and approve, and, as required or requested by Mundipharma, prepare an amendment
to the then-current Development Plan. Such amended Development Plan shall reflect any changes (including additions) to the Development of the Product in the Field by Mundipharma. Once approved by the JPC, the amended Development Plan shall become
effective and supersede the previous Development Plan as of the date of such approval. Promptly after the Parties agree to conduct an Additional Study proposed by Mundipharma pursuant to Section 4.4(b), or Mundipharma decides to proceed with an
Incremental Study pursuant to Section 4.4(c), the JPC shall prepare, review and approve an amendment to the Development Plan that adds such Additional Study or Incremental Study to the Development Plan. 

(d) Performance. Each Party shall use Reasonably Diligent Efforts to conduct the Development activities allocated to such Party in
the Development Plan or the Allos Required Studies Schedule, as applicable, in a timely and effective manner. Each Party shall conduct its activities under the Development Plan or the Allos Required Studies Schedule, as applicable, in a good
scientific manner and comply in all material respects with all applicable Laws. 
 4.3 Omitted. 

4.4 Future Development Activities. 
 (a) Proposed Study. If either Party wishes to conduct and/or fund any additional Development activities in the Field (including company-sponsored studies to explore the utility of the Product in
the Field and/or to expand the label of the Product in such Party’s territory to include additional Indications and also including testing one or more New Forms) that are not already set forth in the Development Plan or the Allos Required
Studies Schedule (each of the foregoing activities, a “Proposed Study”), the proposing Party shall present to the other Party’s representatives on the JPC the proposed design and timeline for such Proposed Study and the
proposed budget for such Proposed Study. The JPC shall discuss such Proposed Study at its next meeting, whether regularly scheduled or specially requested under Section 3.1(c), and the proposing Party shall provide, within [***] after such JPC
meeting (or such longer period of time as agreed upon in writing by the Parties), any additional information reasonably requested by the other Party’s JPC representatives prior to or during such JPC meeting. 

(b) Additional Study. If within [***] after the JPC meeting at which a particular Proposed Study is
discussed (or such longer period of time as agreed upon in writing by the Parties) (i) the other Party notifies the proposing Party in writing that the other Party wishes to cooperate in such Proposed Study, and any Related Studies contemplated
at such time, on the terms (including design, budget and timeline) proposed by the proposing Party or (ii) the Parties agree in writing upon the terms (including design, budget, timeline and rights and obligations upon wind-down or

  
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termination) under which they will cooperate in such Proposed Study, then it will be deemed an “Additional Study.” If such Additional Study is
proposed by Mundipharma, the Development Plan shall be amended pursuant to Section 4.2(c) to include such Additional Study. The Parties shall have the diligence obligations with respect to such Additional Study as provided in
Section 4.2(d). The Parties shall share all Joint Development Costs incurred to conduct such Additional Study in accordance with the applicable budget and in the proportions mutually agreed by the Parties. All Information resulting from such
Additional Study will be available for use by each Party with respect to the Development and Commercialization of the Product in the Field in its respective territory in accordance with the licenses and rights granted or retained under Article 2 of
this Agreement. 
 (c) Incremental Studies. 

(i) If all information reasonably requested by the non-proposing Party has been provided by the proposing Party and by the [***]
after the JPC meeting at which a particular Proposed Study is discussed (or such longer period of time as agreed upon in writing by the Parties) under Section 4.4(b): (x) (1) the other Party has not notified the proposing Party in
writing that the other Party wishes to cooperate in such Proposed Study on the terms (including design, budget and timeline) proposed by the proposing Party, or (2) the Parties have not agreed in writing upon the terms (including design, budget
and timeline) under which they will cooperate in such Proposed Study, and (y) if Mundipharma is the proposing Party, Allos has not notified Mundipharma that it believes that such Proposed Study is substantially likely to create a Material
Impact, then such Proposed Study will be deemed an “Incremental Study”, the proposing Party shall be deemed the “Conducting Party” with respect to such Incremental Study, the other Party shall be deemed the
“Non-Conducting Party” with respect to such Incremental Study and, unless the Conducting Party notifies the JPC that it does not wish to proceed with such Incremental Study, (A) if Mundipharma is the Conducting Party, the
Development Plan shall be amended pursuant to Section 4.2(c) to include an Incremental Study and to specify Mundipharma as solely responsible for the conduct and costs of such Incremental Study, and (B) if Allos is the Conducting Party,
Allos shall be solely responsible for the conduct and costs of such Incremental Study. The Non-Conducting Party shall not be responsible for any costs, including milestones, unless such Non-Conducting Party opts-in to such Incremental Study pursuant
to Section 4.4(c)(v). Mundipharma as the Conducting Party may proceed with an Incremental Study only after an amendment to the Development Plan. If Allos believes that a Proposed Study is substantially likely to create a Material Impact and
Mundipharma disputes whether such belief is reasonable, the JPC shall discuss and decide whether such belief is reasonable. The Proposed Study shall be deemed an Incremental Study if the JPC decides that Allos’ belief is not reasonable. If the
JPC agrees that Allos’ belief is reasonable, then Mundipharma shall not proceed with the Proposed Study. If the JPC cannot agree whether Allos’ belief is reasonable, then such dispute shall be handled in accordance with
Section 13.2. 
 (ii) Notwithstanding each Party’s exclusive commercial rights to its respective
territory, Mundipharma shall have the right to conduct an Incremental Study in patients in the Allos Territory (subject to Section 4.4(c)(i) above), and Allos shall have the right to conduct an Incremental Study in patients in the Licensed
Territory. 

  
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 (iii) The Conducting Party shall promptly inform the JPC of any material changes it
wishes to make to an Incremental Study, including the budget therefor, and, if Mundipharma is the Conducting Party, the Development Plan shall be amended to address them unless, Allos believes that the amendment is substantially likely to have a
Material Impact, in which case the JPC shall review such amendment and approve it only if the JPC decides that Allos’ belief is not reasonable. If the JPC agrees that Allos’ belief is reasonable, Mundipharma shall proceed without such
material changes. If the JPC cannot agree whether Allos’ belief is reasonable, then such dispute shall be handled in accordance with Section 13.2. The Conducting Party may suspend or terminate an Incremental Study without obtaining
approval from the JPC if there is a Safety Reason or such suspension or termination is required by a Regulatory Authority or investigational review board; provided, the Conducting Party shall promptly notify the JPC of any such suspension or
termination. 
 (iv) Promptly following the availability of interim data from or completion of an
Incremental Study, the Conducting Party shall deliver to the JPC the top-line data summary from such Incremental Study. The Non-Conducting Party will have no rights to use any Information resulting from such Incremental Study in any filings with
Regulatory Authorities, for Commercialization in its territory, or otherwise, provided, however, that the Non-Conducting Party may file required safety information with the applicable Regulatory Authorities in its territory in
accordance with Section 4.8(b) and refer to the Regulatory Materials in accordance with Section 5.4. 
 (v)
Opt-In. 
 (A) Within [***] of the Conducting Party having obtained final results in an Incremental Study
establishing Clinical Proof of Concept, such Conducting Party shall deliver to the Non-Conducting Party the top-line data summary from such Incremental Study (the delivery date of such top-line data summary, the “Opt-In Option
Date”), and the Non-Conducting Party with respect to such Incremental Study shall have the right (the “Opt-In Right”) to convert such Incremental Study to an Additional Study by (1) making a payment to the Conducting
Party of a mutually agreeable amount as Non-Conducting Party’s share of the development costs already incurred by the Conducting Party (which amount shall take into account the cost incurred by the Conducting Party to perform such Incremental
Study and an appropriate premium to be paid by the Non-Conducting Party to exercise such Opt-In Right) (such payment, the “Opt-In Payment”), and (2) agreeing with the Conducting Party upon the budget, timeline, rights and
obligations upon wind-down or termination and allocation of operational responsibility for Development activities, if any, to be performed with respect to such Incremental Study and all Related Studies after the exercise of such Opt-In Right and
committing to pay its mutually agreed share of Joint Development Costs incurred with respect to such Incremental Study and Related Studies after the exercise of such Opt-In Right. 

(B) If the Non-Conducting Party with respect to such Incremental Study is considering exercising its Opt-In Right with respect to
such Incremental Study, it shall, no later than [***] after the Opt-In Option Date, notify the Conducting Party in writing and shall request that the Conducting Party provide: (1) an estimate for the Opt-In Payment (the “Opt-In
Estimate”), which estimate shall be based upon the development costs already incurred by the Conducting Party with respect to such Incremental Study together with those anticipated to be incurred by the Conducting Party (as contemplated by
Section 4.4(c)(v)(A)(1)), within [***] after the date of such notice (in each case, calculated as described in Section 4.4(c)(v)(A)(1)); and (2) a proposal to convert 

  
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an Incremental Study to an Additional Study, which amendment shall address the items specified in Section 4.4(c)(v)(A)(2), to the extent applicable to such Incremental Study. The Conducting
Party shall provide such estimate and proposal, together with reasonable documentation of the Conducting Party’s already incurred costs, within [***] after such notice (or such longer period of time as agreed upon in writing by the Parties).
The Conducting Party shall promptly answer all reasonable questions posed by, and provide all additional documents reasonably requested by, the Non-Conducting Party with respect to the Opt-In Estimate. The JPC shall discuss such proposed conversion
at its next meeting, whether regularly scheduled or specifically requested under Section 3.1(c). The Conducting Party shall provide, within [***] after such JPC meeting (or such longer period of time as agreed upon in writing by the Parties),
any additional information reasonably requested by the Non-Conducting Party’s JPC representatives prior to or during such JPC meeting. The Non-Conducting Party shall be deemed to have exercised its Opt-In Right with respect to such Incremental
Study if, within [***] after the JPC meeting at which such proposed amendment to the Development Plan is discussed (or such longer period of time as agreed upon in writing by the Parties), the Conducting Party receives payment of the Opt-In Estimate
amount and the JPC reviews and approves the proposal to convert such Incremental Study to an Additional Study, which proposal addresses the items specified in Section 4.4(c)(v)(A)(2), to the extent applicable to such Incremental Study.

 (C) Upon exercise of the Opt-In Right with respect to a particular study, such study shall cease to be an Incremental
Study and shall be deemed to be an Additional Study, the Parties shall share all future Joint Development Costs associated therewith as mutually agreed and the Parties shall have the diligence obligations with respect to such Additional Study as
provided in Section 4.2(d). 
 (d) Related Studies. The agreement by the Parties to any Additional Study
under this Section 4.4, whether from the outset of the study pursuant to Section 4.4(a) or (b), or through either Party’s exercise of its Opt-In Right to an Incremental Study pursuant to Section 4.4(c)(v), shall not be deemed an
agreement by the Parties to cooperate in any and all related studies necessary for the implementation of such Additional Study or to obtain Drug Approval in the U.S. and all Major Market Countries in the applicable new Indication or new formulation
that is the subject of such Additional Study (excluding any related studies that are required exclusively to obtain Drug Approval in the U.S. and not in any Major Market Country) (each such related study, a “Related
Study”). Upon the agreement by the Parties to any Additional Study under this Section 4.4, the Parties shall use good faith efforts to discuss and agree on the terms (including design, budget, timeline and rights and obligations upon
wind-down or termination) under which they will cooperate in any Related Studies that may be necessary. If, after discussion, the Parties cannot agree on the terms (including design, budget, timeline and rights and obligations upon wind-down or
termination) under which they will cooperate in such Related Study, (i) the conducting Party may conduct the Related Study and shall be solely responsible for such conduct and the costs of such Related Study, and (ii) the terms of
Section 4.4 shall apply to any such Related Study as if such Related Study is an Incremental Study. If the Parties agree on the terms of any Related Study, the terms of Section 4.4 shall apply to any Related Study in the same manner that
they apply to the Additional Study to which such Related Study relates. 

  
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 (e) Manufacture. With respect to any Additional Study or Incremental Study (for which
either Party is the Conducting Party) that involves a New Form, the Conducting Party shall offer the Non-Conducting Party the opportunity to be the supplier of such New Form. Unless the Non-Conducting Party informs the Conducting Party that it is
not interested in being, or is unable to be, the supplier of such New Form, the Parties shall negotiate in good faith and enter into a separate supply agreement that sets forth the terms and conditions under which the Non-Conducting Party will
supply such New Form to the Conducting Party (in the event of an Incremental Study) or one or both Parties (in the event of an Additional Study). If the Non-Conducting Party informs the Conducting Party that it is not interested in being, or is
unable to be, the supplier of such New Form, then the Non-Conducting Party shall grant to the Conducting Party a non-exclusive, royalty-free limited right and license, under the Allos Manufacturing Know-How and Allos Patents, or Mundipharma
Know-How, Mundipharma-Controlled manufacturing-related Information and Mundipharma Patents, as applicable, to manufacture such New Form, with (in the event Mundipharma is the Conducting Party) the right to sublicense in accordance with
Section 2.1(f) to its Affiliates or, with the prior written consent of the Non-Conducting Party, to a Third Party manufacturer (which consent shall not be unreasonably withheld, conditioned or delayed), solely for use in accordance with this
Agreement. 
 4.5 Development Costs. The Parties shall each be responsible for their respective share (i.e., the
Allos Share or the Mundipharma Share, as applicable) of all Joint Development Costs incurred up to and including the Transition Date pursuant to the Original Agreement. After the Effective Date, the Parties shall share all Joint Development Costs
incurred to conduct an Additional Study in the proportions mutually agreed by the Parties. Allos shall also be responsible for all costs and expenses of the Allos Studies. The Party conducting an Incremental Study shall be solely responsible for all
costs and expenses of such Incremental Study, unless the other Party exercises its Opt-In Right with respect to such study in accordance with Section 4.4(c)(v). 
 4.6 Diligence. Mundipharma and Allos shall each use Reasonably Diligent Efforts to Develop the Product in each country in the Licensed Territory in accordance with their respective activities under
the Development Plan and the Allos Required Studies Schedule, respectively; provided, that Mundipharma shall comply with the Development milestones in Japan (the “Japan Milestones”) set forth in the Amended Development Plan.

 4.7 Investigator Sponsored Studies. 
 (a) Before either Party authorizes or facilitates an investigator to conduct an ISS for the Product in the Field, such Party shall notify the other Party in writing, which notice shall provide a
reasonably detailed description of such ISS and shall provide the other Party a reasonable opportunity to review and comment upon such ISS. Such Party shall give reasonable consideration to the other Party’s comments. 

(b) If Mundipharma proposes to authorize or facilitate an investigator to conduct an ISS for the Product in the Field, Allos shall
have [***] after the notice required under Section 4.7(a) is given (or such longer period of time as agreed upon in writing by the Parties) to allege that the conduct of such ISS is substantially likely to create a Material Impact and if
Mundipharma disagrees with such allegation, then the JPC shall discuss and decide whether such 

  
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belief is reasonable. Mundipharma may proceed with the proposed ISS, if the JPC decides that Allos’ belief is not reasonable. If the JPC agrees that Allos’ belief is reasonable, then
Mundipharma shall not proceed with the ISS. If the JPC cannot agree whether Allos’ belief is reasonable, then such dispute shall be handled in accordance with Section 13.2. 

(c) ISSs shall not be included in the Development Plan or the Allos Required Studies Schedule. 

(d) A Party authorizing or facilitating an ISS pursuant to this Section 4.7 shall only receive disclosure, access or a license
to any Information or Patent arising from such ISS under terms that allow such Party to Control such Information or Patent, such that such Information or Patent shall be included in Allos ISS Technology if such Party is Allos or Mundipharma ISS
Technology if such Party is Mundipharma. Such Party shall disclose all such Information and Patents to the other Party promptly following its receipt of disclosure of or access to such Information or Patent. 

4.8 Data Exchange and Use. Upon the Effective Date, Allos shall provide Mundipharma with access, free of charge, to all Allos
Know-How then in existence that constitutes pre-clinical or clinical data relating to the Product. For clarity, Allos does not have any obligation to disclose or provide access to any Information with respect to manufacture of the Product except in
the event the license under Section 2.1(c) becomes effective and then only in accordance with Section 2.1(c) and the Supply Agreement. In addition to its adverse event and safety data reporting obligations pursuant to Section 5.7,
each Party shall promptly provide the other Party with access to, at no additional charge: 
 (a) all safety,
clinical and other development Information (including, if requested, raw data) associated with the conduct of the Shared Studies, as reasonably necessary or useful to support such other Party’s Development or Commercialization of the Product in
the Field in accordance with this Agreement, including rights of access and reference to Regulatory Materials; and 

(b) all safety Information (including, if requested, raw data) generated pursuant to any Incremental Study which the
Non-Conducting Party is required by a Regulatory Authority in its territory to file with such Regulatory Authority to support safety disclosure requirements. The Non-Conducting Party shall have no rights to use any other Information arising from
such Incremental Study in any filings with Regulatory Authorities in its territory (i.e., in the Allos Territory where Allos is the Non-Conducting Party and in the Licensed Territory where Mundipharma is the Non-Conducting Party) unless and
until such Non-Conducting Party exercises its right, pursuant to Section 4.4(c)(v), to convert such Incremental Study to an Additional Study. 
 4.9 Development Reports. Each Party shall provide the JPC with written reports detailing its Development activities under this Agreement and the results of such
activities at least [***] in advance of each regularly scheduled JPC meeting; provided, subject to Section 4.4(c)(iv), such reports will not include the results of any Incremental Studies for which the other Party has not
exercised its Opt-In Right and made the payments required to be made under Section 4.4. The Parties shall discuss the status, progress and results of each Party’s Development activities under this Agreement at such regularly
scheduled JPC meetings. 

  
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 4.10 Development Records. Each Party shall maintain complete, current and accurate
records of all Development activities conducted by it hereunder, and all data and other Information resulting from such activities. Such records shall fully and properly reflect all work done and results achieved in the performance of the
Development activities in good scientific manner appropriate for regulatory and patent purposes. Each Party shall document all non-clinical studies and clinical trials in formal written study records according to applicable Laws, including
applicable national and international guidelines such as ICH, GCP and GLP. Each Party shall have the right to review and copy such records maintained by the other Party at reasonable times, and upon reasonable notice, to obtain access to the
original records to the extent such Party has a license to use the Information contained in such records. 
 4.11
Compliance with Laws. Each Party shall conduct its activities under this Agreement in a good scientific manner and comply in all material respects with all applicable Laws, including applicable national and international guidelines such as ICH,
GCP and GLP. 
 4.12 Allos’ Other Licensees. For clarity, if Allos grants a Third Party an exclusive license
to Develop and/or Commercialize a Product in any country in the Allos Territory, then such licensee may directly exercise Allos’ rights pursuant to this Agreement with respect to such Product in such country; provided, that a licensee in a
Transferred Country shall not have the right to enforce any provision of this Agreement against Mundipharma. 
 ARTICLE
5 
 REGULATORY MATTERS 
 5.1 Regulatory Responsibilities in the Licensed Territory. 

(a) Omitted. 
 (b) Commencing on the Original Effective Date with respect to all countries of the Licensed Territory, Mundipharma shall use Reasonably Diligent Efforts in respect of the Product as the primary
interface with and shall otherwise handle all correspondence, meetings and other interactions with the relevant Regulatory Authorities concerning regulatory activities related to the Product in the Field in the Licensed Territory, and Mundipharma
shall be responsible for preparing and filing any and all Regulatory Materials for the Product in the Field in the Licensed Territory at its sole expense. Allos shall assist and cooperate at its own expense with Mundipharma in connection with the
preparation and filing of such Regulatory Materials, as reasonably requested by Mundipharma, including preparation of ongoing clinical trials, study reports and Periodic Safety Update Reports (“PSURs”). Such cooperation will include
promptly responding within procedural timelines set by Regulatory Authorities to any reasonable request from Mundipharma for Allos Know-How needed for the Regulatory Materials. For clarity, Allos shall not be obligated to provide Mundipharma with
any Information that is not Allos Know-How. 

  
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 (c) Mundipharma shall keep Allos informed at JPC meetings of regulatory developments
relating to the Product in the Field in the Licensed Territory and shall promptly notify Allos in writing of any action or decision by any Regulatory Authority in the Licensed Territory regarding the Product in the Field. Mundipharma shall provide
Allos for review and comment all draft Regulatory Materials (other than routine correspondence such as IND and MAA annual reports, MAA reapproval, during the investigational phase minor protocol amendments, IND amendments for new investigators or
new clinical preclinical studies) at least [***] (or in the event of a shorter filing deadline, as soon as practicable) in advance of their intended date of submission to a Regulatory Authority in the Licensed Territory and shall consider in good
faith any comments thereto provided by Allos. Mundipharma shall promptly notify Allos of any Regulatory Materials (other than routine correspondence such as IND and MAA annual reports, MAA reapproval, during the investigational phase minor protocol
amendments, IND amendments for new investigators or new clinical preclinical studies) submitted to or received from any Regulatory Authority in the Licensed Territory and shall provide Allos with copies thereof, in electronic Common Technical
Document (“eCTD”) format, where applicable, within [***] after submission or receipt. Mundipharma shall provide Allos with reasonable advance notice of all meetings, conferences and discussions scheduled with any Regulatory
Authority in the Licensed Territory concerning the Product, and shall consider in good faith any input from Allos in preparing for such meetings, conferences or discussions. To the extent permitted by applicable Laws, Allos shall have the right to
participate in any such meetings, conferences or discussions and Mundipharma shall facilitate such participation. If Allos elects not to participate in such meetings, conferences or discussions, Mundipharma shall provide Allos with written summaries
of such meetings, conferences or discussions in English as soon as practicable after the conclusion thereof. 
 (d) Within
[***] of the Original Effective Date, Allos provided Mundipharma, in eCTD format, with a full copy of the DAA filed by Allos and validated by the EMA on December 15, 2010. 

(e) Allos shall be responsible for compiling and providing to Mundipharma the CMC Information that is required for Mundipharma to
obtain and maintain Regulatory Approval of the Product in the Licensed Territory. Mundipharma shall use the CMC Information provided to it by Allos for the purpose of obtaining and maintaining Regulatory Approval of the Product in the Licensed
Territory and in connection with the exercise of its license under section 2.1(c). At Mundipharma’s request, Allos shall provide reasonable assistance to Mundipharma with respect to communications with Regulatory Authorities in the Licensed
Territory regarding the manufacture of the Product or the CMC Information. 
 (f) Unless the Parties otherwise
agree in writing: (i) except as expressly contemplated by Sections 5.1(b) or 5.1(e), Allos shall not communicate with respect to the Product in the Field with any Regulatory Authority having jurisdiction in the Licensed Territory, or unless so
ordered by such Regulatory Authority, in which case Allos shall provide immediate notice to Mundipharma of such order; and (ii) Allos shall not submit any Regulatory Materials or seek Regulatory Approvals for the Product in the Field in the
Licensed Territory. 

  
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 5.2 Regulatory Responsibilities in the Allos Territory. 

(a) Allos shall own all Regulatory Materials (including Regulatory Approvals) for the Product in the Allos Territory, and shall be
responsible for preparing and filing any and all Regulatory Materials for the Product in the Allos Territory at its sole expense. Mundipharma shall assist and cooperate with Allos in connection with the preparation and filing of such Regulatory
Materials, as reasonably requested by Allos and at Allos’ sole expense. 
 (b) Allos shall keep Mundipharma informed
of regulatory developments relating to the Product in the Field in the Allos Territory through regular reports at the JPC meetings and shall promptly notify Mundipharma in writing of any action or decision by any Regulatory Authority in the Allos
Territory relating to the Product. Allos shall provide Mundipharma for review and comment all draft Regulatory Materials (other than routine correspondence such as IND and NDA annual reports, during the investigational phase minor protocol
amendments, IND amendments for new investigators or new clinical preclinical studies), at least [***] (or in the event of a shorter filing deadline, as soon as practicable) in advance of the intended date of submission to a Regulatory Authority in
the Allos Territory and shall consider in good faith any comments thereto provided by Mundipharma. Allos shall promptly notify Mundipharma of any Regulatory Materials (other than routine correspondence such as IND and NDA annual reports, during the
investigational phase minor protocol amendments, IND amendments for new investigators or new clinical preclinical studies) submitted to or received from any Regulatory Authorities in the Allos Territory and shall provide Mundipharma with copies
thereof, in eCTD format, within [***] after submission or receipt. 
 (c) Unless the Parties otherwise agree in
writing: (i) except as expressly contemplated by Section 5.2(a), Mundipharma shall not communicate with respect to the Product with any Regulatory Authority having jurisdiction in the Allos Territory, unless so ordered by such Regulatory
Authority, in which case Mundipharma shall provide immediate notice to Allos of such order; and (ii) Mundipharma shall not submit any Regulatory Materials or seek Regulatory Approvals for the Product in the Allos Territory. 

(d) Allos shall use Reasonably Diligent Efforts to maintain the existing Drug Approval for the Product in the Field in the U.S.,
including conducting the Allos Required Studies; provided, however, that Allos may discontinue a Allos Required Study (A) if such study is no longer required by the FDA for Drug Approval or maintenance of Drug Approval in the U.S., or
(B) for Material Impact or Safety Reason. Allos may not discontinue an Allos Required Study solely as a result of Allos’ development or commercialization efforts with respect to another product in the Field in the U.S.; provided, that if
Allos decides to discontinue an Allos Required Study for any reason (other than that such study is no longer required by the FDA for Drug Approval or maintenance of Drug Approval in the U.S. or for Material Impact or Safety Reason), (i) it
shall provide [***] prior written notice to Mundipharma of such decision; and (ii) within [***] after receipt of such written notice from Allos, Mundipharma may elect, by sending a written notice to Allos, to reimburse Allos for its approved
out-of-pocket costs and expenses incurred in connection with continuing such Allos Required Study (the “Required Additional Study Election”), as follows, and provided that such election, once made, shall be Mundipharma’s sole
and exclusive remedy for Allos’ discontinuance of an Allos Required Study: 
 (1) Within [***] after the
exercise of the Required Additional Study Election by Mundipharma, Allos will submit to Mundipharma a detailed budget showing the out-of-pocket costs and expenses that Allos expects to incur, from the date of Mundipharma’s exercise of the
Required Additional Study Election onwards, in connection with the completion of the Allos Required Additional Study. Allos will also update such budget on a [***] basis. 

  
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 (2) Mundipharma will have the right to review and approve such costs and expenses,
such approval not to be unreasonably withheld or delayed. 
 (3) Mundipharma agrees to reimburse Allos, on a [***]
basis, for all of Allos’ pre-approved and actual out-of-pocket costs and expenses incurred from the date of Mundipharma’s exercise of the Required Additional Study Election onwards, in connection with the continuation of the Allos Required
Additional Study. 
 (4) Within [***] following the end of each [***] after the exercise of the Required
Additional Study Election by Mundipharma, Allos shall submit a report showing such costs and expenses incurred by Allos in the preceding [***]. 
 (5) Mundipharma shall be entitled to deduct from royalties on Net Sales payable to Allos pursuant to Section 7.4(a), up to (a) [***] of any amounts reimbursed to Allos pursuant to this
Section 5.2(d), if the discontinuation of the study is due to Allos’ development or commercialization efforts with respect to another product in the Field in the U.S., and (ii) [***] of any amounts reimbursed to Allos pursuant to this
Section 5.2(d), if the discontinuation of the study is due to any other reason except that such study is no longer required by the FDA for Drug Approval or maintenance of Drug Approval in the U.S. or for Material Impact or Safety Reason.

 (6) Mundipharma may, upon written notice to Allos, and at any time after its exercise of the Required Additional
Study Election, cease reimbursing Allos for Allos’ out-of-pocket costs and expenses towards the completion of the Allos Required Additional Study. Should Mundipharma so elect to cease such reimbursement, Allos may discontinue the Allos Required
Additional Study without any liability towards Mundipharma. 
 5.3 Regulatory Costs. Commencing on the [***] with
respect to [***] shall be solely responsible for all of its costs and expenses related to the preparation, filing and maintenance of all Regulatory Materials and Regulatory Approvals for [***]. [***] shall be solely responsible for all costs and
expenses related to the preparation, filing and maintenance of all Regulatory Materials and Regulatory Approvals for [***]. 
 5.4 Rights of Reference to Regulatory Materials. Allos hereby grants to Mundipharma a right of reference to all Regulatory Materials filed by or on behalf of Allos
(including by its licensees), which right of reference Mundipharma may use for the sole purpose of seeking, obtaining and maintaining Regulatory Approvals and Developing and Commercializing the Product in the Field in the Licensed Territory.
Mundipharma hereby grants to Allos and Allos’ licensees in the Allos Territory a right of reference to all Regulatory Materials filed by or on behalf of Mundipharma, which right of reference Allos may use for the sole purpose of seeking,
obtaining and maintaining Regulatory Approvals and Developing and Commercializing the Product in the Field in the Allos Territory. Each Party shall support the other Party, as reasonably requested by such other Party, in obtaining Regulatory
Approvals in such other Party’s territory, including providing necessary documents or other materials required by applicable Laws to obtain Regulatory Approval in such territory, all in accordance with the terms and conditions of
this Agreement. 

  
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 5.5 No Harmful Actions. 

(a) If Allos reasonably believes that Mundipharma is taking or intends to take any action with respect to the Product that is
substantially likely to have a Material Impact in the Allos Territory, Allos shall give written notice to Mundipharma. If Mundipharma disputes whether Allos’ such belief is reasonable, the matter will be submitted to the JPC for its review and
determination as to whether such belief is reasonable. Mundipharma shall not proceed with any such action or alternative course of action until it is approved by Allos, or the JPC in writing, as applicable. If the JPC cannot agree whether
Allos’ belief is reasonable, then such dispute shall be handled in accordance with Section 13.2. 
 (b) If
Mundipharma reasonably believes that Allos is taking or intends to take any action with respect to the Product that is substantially likely to have a Material Impact in the Licensed Territory, Mundipharma shall have the right to bring the matter to
the attention of the JPC. Allos shall not proceed with any such action or alternative course of action until it is approved by the JPC in writing in accordance with Section 3.1(d). If the JPC cannot agree whether Mundipharma’s belief is
reasonable, then such dispute shall be handled in accordance with Section 13.2. 
 5.6 Notification of Threatened
Action. Each Party shall immediately notify the other Party of any information it receives regarding any threatened or pending action, inspection or communication by or from any Third Party, including a Regulatory Authority, which may affect the
Development, Commercialization or regulatory status of the Product. Upon receipt of such information, the Parties shall consult with each other in an effort to arrive at a mutually acceptable procedure for taking appropriate action.

 5.7 Adverse Event Reporting and Safety Data Exchange. Prior to the Effective Date, the Parties defined and
finalized the actions that the Parties shall employ with respect to Products to protect patients and promote their well-being in two written pharmacovigilance agreements (the “Pharmacovigilance Agreements”). The existing
Pharmacovigilance Agreement(s) shall be amended by the Parties within [***] of the Effective Date in order to align it/them with the provisions of this Agreement and the Supply Agreement. Each Party hereby agrees to comply with its respective
obligations under the Pharmacovigilance Agreement(s), as amended, and to cause its Affiliates and sublicensees to comply with such obligations. 
 5.8 Remedial Actions. Each Party will notify the other Party immediately, and promptly confirm such notice in writing, if it obtains information indicating that the
Product may be subject to any recall, corrective or other regulatory action taken by virtue of applicable Laws (a “Remedial Action”). The Parties will assist each other in gathering and evaluating such
information as is necessary to determine the necessity of conducting a Remedial Action. Each Party shall, and shall ensure that its Affiliates and sublicensees will, maintain adequate records to permit the Parties to trace the manufacture,
distribution and use of the Product. In the event Mundipharma determines that any Remedial Action with respect to the Product in the Field in the Licensed Territory should be commenced or is required by the applicable Regulatory Authority,
Mundipharma shall have the right 

  
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to control and coordinate all efforts necessary to conduct such Remedial Action; provided that, with respect to any such Remedial Action that is not imposed upon Mundipharma
by applicable Law or a Regulatory Authority, such Remedial Action shall have been reviewed and approved by the JPC. In the event Allos determines that any Remedial Action with respect to the Product in the Field in the Allos Territory should be
commenced or is required by the applicable Regulatory Authority, Allos shall have the right, at its expense, to control and coordinate all efforts necessary to conduct such Remedial Action; provided that, with respect to any such Remedial Action
that is not imposed upon Allos by applicable Law or a Regulatory Authority, such Remedial Action shall have been reviewed and approved by the JPC. If the JPC fails to approve a Remedial Action that is not imposed upon a Party by applicable Law or
Regulatory Authority within [***] after such Remedial Action is presented to the JPC for review and approval, then the Parties’ Executive Officers shall, within [***] thereafter, review and approve such Remedial Action or, in the event that the
Executive Officers fail to approve such Remedial Action within such time period, the Party that has the right to control and coordinate the efforts necessary to conduct such Remedial Action as provided above shall have the final decision-making
authority regarding such Remedial Action notwithstanding Section 13.1 or 13.2. Notwithstanding the foregoing, any Remedial Action that relates to the manufacture and supply of the Product by Allos to Mundipharma shall be governed by the terms
and conditions of the Supply Agreement. 
 ARTICLE 6 

COMMERCIALIZATION 
 6.1 Overview of Commercialization in the Licensed Territory. Subject to the terms and conditions of this Article 6, as between the Parties, Mundipharma will be responsible for all aspects of the
Commercialization of the Product in the Field in the Licensed Territory, including: (a) developing and executing a commercial launch and pre-launch plan, (b) negotiating with applicable Governmental Authorities regarding the price and
reimbursement status of the Product; (c) marketing and promotion; (d) booking sales, and distribution and performance of related services; (e) handling all aspects of order processing, invoicing and collection, inventory and
receivables; (f) providing customer support, including handling medical queries, and performing other related functions; and (g) conforming its practices and procedures to applicable Laws relating to the marketing, detailing and promotion
of the Product in the Field in the Licensed Territory. Mundipharma shall bear all of the costs and expenses incurred in connection with such Commercialization activities. 

6.2 Commercialization Plan for Licensed Territory. 
 (a) General. Mundipharma shall Commercialize the Product in the Field in the Licensed Territory pursuant to a detailed plan prepared by Mundipharma and submitted by
Mundipharma to the JPC for review, comment and discussion (the “Commercialization Plan”). The Commercialization Plan will include (i) a reasonably detailed description and timeline of
Mundipharma’s Commercialization activities in the Field in each of the Major Market Countries for the next year, including medical marketing activities, sales forecasts and projections, pricing, reimbursement, market research, sales training,
distribution channels, customer service and sales 

  
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force matters related to the launch and sale of the Product in such country in such year, (ii) an overview of Mundipharma’s Commercialization activities in the
Field in all other countries in the Licensed Territory for the next year and (iii) a strategic plan for Commercialization of the Product in the Field in the Licensed Territory for the following two (2) years. 

(b) Initial Plan and Amendments. The initial Commercialization Plan shall be delivered to the JPC no later than [***] after the
Original Effective Date or [***] before the anticipated launch of the Product in the Licensed Territory, whichever is later, for review, comment and discussion. On at least an annual basis, Mundipharma shall prepare an amendment, as
appropriate, to the then-current Commercialization Plan. Mundipharma shall submit all amendments to the Commercialization Plan to the JPC for review, comment and discussion. Once reviewed by the JPC, the amended Commercialization Plan shall become
effective and supersede the previous Commercialization Plan as of the date of such review. 
 6.3 Pricing.
Mundipharma shall have the sole right to determine all pricing of Products in the Field in the Licensed Territory. For the avoidance of doubt, Allos shall not have any right to direct, control, or approve Mundipharma’s pricing of Products in
the Field in the Licensed Territory. 
 6.4 Pricing Approval. On a country-by-country basis and subject to
Section 6.6(b), Mundipharma will use Reasonably Diligent Efforts to obtain and maintain Pricing Approval for the Product in the Field in each country in the Licensed Territory in which it has obtained Drug Approval for such Product in the
Field. Without limiting the foregoing, Mundipharma shall have the sole right to determine the Product’s launch sequence, subject to review and discussion by the JPC. 

6.5 Reimbursement Approval. On a country-by-country basis and subject to Section 6.6(b), Mundipharma will use Reasonably
Diligent Efforts to obtain and maintain Reimbursement Approval for the Product in the Field in each country in the Licensed Territory in which it has obtained Drug Approval for such Product in the Field. 

6.6 Commercial Diligence. 
 (a) Mundipharma shall use Reasonably Diligent Efforts to Commercialize the Product in the Field in each country in the Licensed Territory in which it receives Regulatory Approval. After the launch
of a Product, Mundipharma shall [***]. 
 (b) Mundipharma shall achieve First Reimbursable Commercial
Sale of each Product in a country within [***] after all Regulatory Approvals have been obtained to Commercialize the Product in the Field in such country; provided, however, that Mundipharma is not obligated to launch a particular
Product in a particular country in the Licensed Territory if [***] and provides Allos, within [***] of receipt of final Regulatory Approval in such country, with written notice [***]. Allos may, within a reasonable time after receiving such written
notice from Mundipharma, submit any dispute to the JPC for review and approval and, in the absence of such approval, the terms of Section 13.2 shall apply. Notwithstanding the foregoing or the terms of Section 13.1 or 13.2, if Allos
disputes [***] and if neither the JPC nor the Parties’ Executive Officers are able to resolve such dispute, such dispute shall be resolved by a mutually acceptable, disinterested, conflict-of-interest-free individual (the
“Expert”) as follows: 

  
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 (i) Upon the written request of either Party, the Parties shall promptly negotiate
in good faith to appoint an appropriate Expert who shall have such scientific, technical, regulatory and commercial experience as is necessary to resolve such dispute and who shall not be or have been during the preceding five (5) years an
Affiliate, employee, consultant, officer or director of either Party or any of their respective Affiliates. If the Parties are not able to agree upon an Expert within [***] after the receipt by a Party of the written request in the immediately
preceding sentence, each Party shall select one (1) Expert within [***] thereafter, and those two (2) Experts shall select a third Expert within [***] thereafter and such third Expert (selected by the first two Experts) shall be the
designated Expert for resolution of the dispute. The fees and costs of the Expert shall be borne equally (50-50) by Allos and Mundipharma. 
 (ii) Within [***] after the designation of the Expert, the Parties shall each submit to the Expert and to one another a written statement of their respective positions on whether [***]. Each Party
shall have [***] from receipt of the other Party’s submission to submit a written response thereto, which shall include any scientific, commercial and technical information in support thereof. The Expert shall have the right to meet with the
Parties, either alone or together, as necessary to make a determination. 
 (iii) No later than [***] after the
designation of the Expert, the Expert shall make a determination by selecting the position of one of the Parties that as a whole is the most fair and reasonable to the Parties in light of the totality of the circumstances and the Expert shall
provide the Parties with a written statement setting forth the basis of the determination in connection therewith. The Expert shall not have authority to render any substantive decision other than to select the position proposed by Allos or
Mundipharma. The determination of the Expert shall be final and conclusive. If the Expert determines that [***], Mundipharma shall promptly thereafter launch the Product and shall use Reasonably Diligent Efforts to Commercialize the Product in the
Field in such country. Failure by Mundipharma to launch the Product in such country in the Licensed Territory after the Expert determines that [***] shall (A) with respect to any Major Market Country, [***], and (B) with respect to any
country in the Licensed Territory other than a Major Market Country, [***]; provided that [***]. 
 (c)
Notwithstanding the foregoing provisions of this Section 6.6, if Allos ceases to maintain all Regulatory Approvals for the Product in the Field in the U.S., Mundipharma’s Commercialization obligations set forth in this Section 6.6
shall (as of the date, and for the duration, of such cessation) no longer apply to those countries in the Licensed Territory for which Regulatory Approval is revoked or cancelled as a result of the cessation of the Regulatory Approvals for the
Product in the Field in the U.S. 
 6.7 Cross-Territorial Restrictions. 

(a) Mundipharma hereby covenants and agrees that, insofar as permitted by applicable Law, it shall not,
and shall ensure that its Affiliates and Sublicensees will not, either directly or indirectly, knowingly promote, market, distribute, import, sell or have sold any Product, including via internet or mail order, into countries in the Allos Territory.
As to such countries in the Allos Territory, Mundipharma shall not, and shall ensure that its Affiliates and Sublicensees will not: (i) establish or maintain any branch, warehouse or distribution facility for any Product in such

  
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countries, (ii) engage in any advertising or promotional activities relating to any Product that are directed primarily to customers or other purchasers or users of such Product
located in such countries, (iii) solicit orders from any prospective purchaser located in such countries, or (iv) sell or distribute any Product to any person in the Licensed Territory who it knows intends to sell any Product in such
countries. If Mundipharma receives any order from a prospective purchaser located in a country in the Allos Territory, Mundipharma shall immediately refer that order to Allos, and Mundipharma shall not accept any such orders. Mundipharma shall not
deliver or tender (or cause to be delivered or tendered) any Product into a country in the Allos Territory. Mundipharma shall not, and shall ensure that its Affiliates and Sublicensees will not, restrict or impede in any manner Allos’ exercise
of its retained rights in the Allos Territory. 
 (b) Allos hereby covenants and agrees that, except with
respect to the named patient supply program in effect as of the Original Effective Date or any named patient supply program implemented after the Original Effective Date but prior to the Effective Date and approved by Mundipharma, insofar as
permitted by applicable Law, it shall not, and shall ensure that its Affiliates and sublicensees will not, either directly or indirectly, knowingly promote, market, distribute, import, sell or have sold any Product, including via internet or mail
order, into countries in the Licensed Territory. As to such countries in the Licensed Territory, Allos shall not, and shall ensure that its Affiliates and sublicensees will not: (i) except with respect to any such named patient supply program,
establish or maintain any branch, warehouse or distribution facility for any Product in such countries, (ii) engage in any advertising or promotional activities relating to any Product that are directed primarily to customers or other
purchasers or users of such Product located in such countries (but, for the avoidance of doubt, the foregoing shall not in any way restrict Allos from responding to medical information requests in connection with any such named patient supply
program), (iii) solicit orders from any prospective purchaser located in such countries, or (iv) except with respect to any such named patient supply program, sell or distribute any Product to any person in the Allos Territory who it knows
intends to sell any Product in such countries. If Allos receives any order from a prospective purchaser located in a country in the Licensed Territory except for orders in connection with any such named patient supply program, Allos shall
immediately refer that order to Mundipharma, and Allos shall not accept any such orders. Allos shall not deliver or tender (or cause to be delivered or tendered) any Product into a country in the Licensed Territory except in connection with any such
named patient supply program. Allos shall not, and shall ensure that its Affiliates and sublicensees will not, restrict or impede in any manner (other than with respect to any such named patient supply program) Mundipharma’s exercise of its
licensed rights in the Licensed Territory. For clarity, nothing in this Section 6.7(b) shall preclude or prohibit Allos, directly or indirectly, itself or through its Affiliates or any Third Party, from distributing, importing, selling or
having sold any Product in the Licensed Territory as part of or in connection with a named patient supply program in effect as of the Original Effective Date or a named patient supply program implemented after the Original Effective Date but prior
to the Effective Date and approved by Mundipharma. As soon as practicable after Effective Date, Mundipharma or its Affiliate shall take over the existing named patient supply program in the Licensed Territory (except Switzerland); provided, that
each Party shall use Reasonably Diligent Efforts in light of such Party’s existing contractual obligations to facilitate the expeditious transition of the named patient supply program from the existing named patient supply program distributor
to Mundipharma or its Affiliate. 
 6.8 Territorial Coordination. The Parties shall, where appropriate, coordinate
their Commercialization activities between the Allos Territory and the Licensed Territory, through the JPC, which coordination may include implementation of a global branding strategy for the Product. 

  
 39 

 6.9 Reports. Each Party shall update the JPC at each regularly scheduled JPC meeting
regarding its Commercialization activities with respect to Products in the Field in its applicable territory. Each such update shall be in a form to be agreed by the JPC and shall summarize such Party’s significant Commercialization activities
with respect to Products in the Field in its applicable territory pursuant to this Agreement, covering subject matter at a level of detail reasonably requested by the Parties and sufficient to enable each Party to assess the other Party’s
compliance with its obligations pursuant to Section 6.6. 
 ARTICLE 7 

COMPENSATION 
 7.1 Upfront Payment. In partial consideration of Allos’ investment in Development of the Product in the Field prior to the Original Effective Date, Allos’ provision to Mundipharma of
access to regulatory filings and clinical data generated by Allos with respect to the Product in the Field, and Allos’ grant of an exclusive license to Mundipharma under the Allos Technology, Mundipharma paid to Allos, pursuant to the Original
Agreement, a one-time upfront fee of fifty million Dollars ($50,000,000). Such fee was non-creditable and non-refundable. For the avoidance of doubt, Mundipharma has satisfied its obligations to Allos, and no additional amounts are payable by
Mundipharma to Allos, under this Section 7.1. 
 7.2 Reimbursement of Joint Development Costs.

 (a) Mundipharma shall be responsible for the Mundipharma Share of, and Allos shall be responsible for the Allos Share
of, all Joint Development Costs incurred prior to the Transition Date pursuant to the Original Agreement. Within [***] after the Transition Date, each Party shall submit to the other Party a reasonably detailed invoice setting forth the total Joint
Development Costs incurred by such Party up to and including the Transition Date pursuant to the Original Agreement, and invoicing the other Party for that Party’s share of such Joint Development Costs incurred up to and including the
Transition Date. Each Party shall pay to the other Party the amount invoiced within [***] after the receipt of such invoice. For clarity, subject to the Mundipharma Joint Development Payment provided for in Section 7.2(b) and other costs
specifically agreed to be shared by the parties as set forth Section 7.2(c), Mundipharma shall not be responsible for any Joint Development Costs incurred after the Effective Date. 

(b) Mundipharma shall pay Allos a one-time payment of seven million Dollars ($7,000,000) (the “Mundipharma Joint
Development Payment”) towards research and development costs incurred by Allos prior to and including the Effective Date. The Mundipharma Joint Development Payment shall be due and payable on the earlier of (i) [***] from the Effective
Date, or (ii) [***]. 
 (c) Except for the payment of the Mundipharma Joint Development Payment by
Mundipharma, the Parties shall share all Joint Development Costs incurred to conduct an Additional Study, and any other costs specifically agreed to be shared by the Parties pursuant to this Agreement, in the proportions mutually agreed by the
Parties. Within [***] after the end of each calendar quarter during which either Party has incurred any Joint Development Costs relating to an Additional Study, 

  
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such Party shall submit to the other Party a reasonably detailed invoice setting forth the total Joint Development Costs relating to such Additional Study incurred by such other Party in such
calendar quarter and invoicing such other Party for such Party’s mutually agreed share of such Joint Development Costs relating to such Additional Study. The invoiced Party shall pay to the invoicing Party the amount invoiced within [***] after
the receipt of such invoice. Such invoicing Party will also provide to the invoiced Party a monthly statement of account reflecting such Party’s mutually agreed share of Joint Development Costs relating to any Additional Study previously due
and owing that remains outstanding, if any. 
 (d) All payments made by a Party pursuant to this Section 7.2 shall be
non-refundable. 
 7.3 Milestone Payments. 
 (a) First Reimbursable Commercial Sale and Drug Approval. 

(i) Within [***] after the receipt of the first Drug Approval of the Product for the Lead Indication in Japan, Mundipharma shall
pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 
 (ii) Within [***] of the First
Reimbursable Commercial Sale of the Product for the Lead Indication in Japan, Mundipharma shall pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 

(iii) Within [***] after the receipt of the first Drug Approval of the Product for the First Line PTCL in Japan, Mundipharma shall
pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 
 (iv) Within [***] after receipt of
the first Drug Approval of the Product for the First Line PTCL in China, Mundipharma shall pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 
 (v) Within [***] after receipt of the first Drug Approval of the Product for the First Line PTCL in any country in Latin America (being all of South America, Central America and Mexico),
Mundipharma shall pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 
 (vi) Within
[***] after receipt of the first Drug Approval of the Product for the First Line PTCL in Australia, Mundipharma shall pay to Allos a one-time, non-refundable, non-creditable milestone payment of [***]. 

(b) Milestone Payment in Japan Relating to Solid Tumor and Hematology Indications. Milestone payments from Mundipharma to Allos in
respect of any of the solid tumor and hematology Indications listed in Exhibit A will be discussed and agreed between the Parties at the time any Proposed Studies in respect of such solid tumor and hematology Indications are discussed. If the
Parties are unable to agree on the milestones payments at the time any such Proposed Studies are discussed, Mundipharma shall not file applications for such Regulatory Approvals in respect of any of the solid tumor and hematology Indications listed
in Exhibit A, until such agreement on milestone payments is reached. 

  
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 41 

 (c) Net Sales Milestone Payments in the Licensed Territory. Mundipharma shall
make the following one-time, non-refundable, non-creditable milestone payments to Allos when the aggregate Net Sales of all Products in the Licensed Territory (adjusted for any rebates that are known to be required in respect of the calendar year in
question) first reach the specified amount listed in the “Milestone Event” column below in any calendar year. Mundipharma shall pay to Allos such amount within [***] after the end of the calendar quarter in which such Milestone Event is
achieved. For clarity, the milestone payments in this Section 7.3(c) shall each be paid only once and shall be additive such that if all five Milestone Events set forth below are achieved in the same calendar year, Mundipharma shall pay to
Allos a payment of [***]. 
  

					
	 Milestone Event
	  	Milestone
Payment	 
	 First achievement of aggregate annual Net Sales of all Products in the Licensed Territory equal to or exceeding
[***]
	  	$	[***]	  
	 First achievement of aggregate annual Net Sales of all Products in the Licensed Territory equal to or exceeding
[***]
	  	$	[***]	  
	 First achievement of aggregate annual Net Sales of all Products in the Licensed Territory equal to or exceeding
[***]
	  	$	[***]	  
	 First achievement of aggregate annual Net Sales of all Products in the Licensed Territory equal to or exceeding
[***]
	  	$	[***]	  
	 First achievement of aggregate annual Net Sales of all Products in the Licensed Territory equal to or exceeding
[***]
	  	$	[***]	  

 7.4 Royalties. 
 (a) Royalty Rates. Mundipharma shall pay to Allos non-refundable, non-creditable royalties on Net Sales of all Products in the Licensed Territory during the Royalty Term, as calculated by
multiplying the applicable royalty rate set forth below (subject to Sections 7.4(c), 7.4(d) and 7.4(e)) by the corresponding amount of incremental, aggregated Net Sales of all Products in the Licensed Territory in such calendar year [***].

  
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	 Annual Net Sales of all Products in the Licensed

Territory
	  	Royalty
Rate	 
	 For that portion of annual Net Sales less than or equal to [***]
	  	 	[***]	% 
	 For that portion of annual Net Sales greater than [***] but less than [***]
	  	 	[***]	% 
	 For that portion of annual Net Sales greater than [***]
	  	 	[***]	% 

 (b) Royalty Term. Royalties shall be paid under this Section 7.4 on a
country-by-country basis in the Licensed Territory for Net Sales of Product made during the period from the First Commercial Sale of such Product in such country until the later of: (i) the unappealable revocation of the last,
or expiration of the last to expire, PDX Patent in any country in the world; (ii) the expiration or revocation of the last Allos Patent (excluding the PDX Patents), Joint Patent (if such Joint Patent claims the Product or the API or the
manufacture or use in the Field of the Product or the API) or Mundipharma Patent in such country; and (iii) the [***] anniversary of the First Commercial Sale of such Product in such country (such period, the “Royalty Term”).

 (c) Royalty Reductions for Generic Products. The royalty rates then applicable (i.e., as set forth in
Section 7.4(a) and as such royalties may have been further reduced pursuant to Sections 7.4(d) and 7.4(e)) for Product sold in a particular country in the Licensed Territory during a particular calendar quarter shall be reduced, on a calendar
quarter-by-calendar quarter and country-by-country basis, in accordance with the following if, following the launch of a Generic Product in such country, the sum of the Percentage Price Reduction in such country plus the Percentage Market
Penetration in such country reaches the following percentage thresholds: (i) during any calendar quarter in which the sum of the Percentage Price Reduction and the Percentage Market Penetration in a country in the Licensed Territory is equal to
or greater than [***] but less than [***], the royalty rates for such calendar quarter for Product sold in such country shall be reduced to [***] of the royalty rates then applicable; (ii) during any calendar quarter in which the sum of the
Percentage Price Reduction and the Percentage Market Penetration in a country in the Licensed Territory is equal to or greater than [***] but less than [***], the royalty rates for such calendar quarter for Product sold in such country shall be
reduced to [***] of the royalty rates then applicable; (iii) during any calendar quarter in which the sum of the Percentage Price Reduction and the Percentage Market Penetration in a country in the Licensed Territory is equal to or greater than
[***] but less than [***], the royalty rates for such calendar quarter for Product sold in such country shall be reduced to [***] of the royalty rates then applicable; and (iv) during any calendar quarter in which the sum of the Percentage
Price Reduction and the Percentage Market Penetration in a country in the Licensed Territory is equal to or greater than [***], the royalty rates for such calendar quarter for Product sold in such country shall be reduced to [***]. For clarity, the
foregoing percentage thresholds shall apply on a calendar quarter-by-calendar quarter basis and the royalty reductions applicable to Net Sales in a particular country may fluctuate from one calendar quarter to the next depending upon the
then-existing sum of the Percentage Price Reduction and Percentage Market Penetration in such country; and, for further clarity, in the event that none of the foregoing 

  
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 43 

 
percentage thresholds is met in a country in a calendar quarter, each of (i), (ii), (iii) and (iv) shall cease to apply and the royalty rates payable pursuant to Section 7.4(a) (as
such royalties may have been further reduced pursuant to Sections 7.4(d) and 7.4(e)) shall be reinstated for Product sold in such country during such calendar quarter. 
 (d) Royalty Reduction Upon Reduction or Cessation of PDX License Royalties. In the event royalties cease to be payable by Allos under the PDX License Agreement, the royalty rates in
Section 7.4(a) of this Agreement shall be reduced to [***] for that portion of annual aggregated Net Sales of all Products in the Licensed Territory less than or equal to [***];[***] for that portion of annual aggregated Net Sales of all
Products in the Licensed Territory greater than [***] but less than or equal to [***]; and [***] for that portion of annual aggregated Net Sales of all Products in the Licensed Territory greater than [***]; provided, such royalty rates may be
further reduced pursuant to Sections 7.4(c) and 7.4(e). 
 (e) Royalty Reduction For Third Party License. If, during the
Term, Mundipharma deems it necessary to seek or obtain a license from any Third Party in order to Develop and Commercialize a Product in the Licensed Territory and provided that Allos is named as or otherwise obtains rights as a licensee or
sublicensee (in respect of the Licensed Territory) under such Third Party license, Mundipharma shall be entitled to offset against royalties otherwise due to Allos under this Agreement an amount equal to [***] of any royalties or other fees paid by
Mundipharma to such Third Party under such license; provided, however, in no event shall the reduction provided for in this Section 7.4(e) reduce the royalties payable to Allos during any calendar year by more than [***];
provided, such royalty rates may be further reduced pursuant to Sections 7.4(c) and 7.4(d). 
 (f) Royalty Reports and
Payments. Within [***] following the end of each calendar quarter, commencing with the calendar quarter in which the First Commercial Sale of the Product is made anywhere in the Licensed Territory, Mundipharma shall provide Allos with a report
containing the following information for such calendar quarter, on a country-by-country basis: (i) the amount of gross sales of Product in the Licensed Territory, (ii) an itemized calculation of Net Sales in the Licensed Territory showing
deductions provided for in the definition of “Net Sales” and any rebates that are known to be required in respect of the calendar year in question, (iii) the conversion of such Net Sales from the currency of sale into Dollars, and
(iv) the calculation of the royalty payment due on such sales, showing the application of the reduction, if any, made in accordance with the terms of Sections 7.4(c), 7.4(d) and 7.4(e). Concurrent with the delivery of the applicable quarterly
report, Mundipharma shall pay in Dollars all amounts due to Allos pursuant to this Section 7.4 with respect to Net Sales by Mundipharma, its Affiliates and their respective Sublicensees for such calendar quarter. 

7.5 Blocked Currency. In each country in the Licensed Territory where the local currency is blocked and cannot be removed
from the country, royalties accrued on Net Sales in such country shall be paid to Allos in the equivalent amount in Dollars. 

7.6 Foreign Exchange. Conversion of sales recorded in local currencies to Dollars shall be calculated, on a quarterly basis, using
the mid-point rate of exchange for the last business day of the calendar quarter as reported in the Financial Times (London edition) on the last business day of each calendar quarter in the quarter prior to the date of payment. 

  
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 44 

 7.7 Payment Method; Late Payments. All payments due hereunder shall be made in
Dollars by wire transfer of immediately available funds into an account designated by the Party that is owed such payment (such Party, the “Payee”). If the Payee does not receive payment of any sum due to it on or before the due
date, simple interest shall thereafter accrue on the sum due to the Payee until the date of payment at the per annum rate of [***] over the then-current prime rate as reported in The Wall Street Journal or the maximum rate allowable by applicable
Laws, whichever is lower. 
 7.8 Records. Each Party shall keep (and shall ensure that its Affiliates and
sublicensees keep) such records as are required to determine, in accordance with U.S. generally accepted accounting principles or international financial reporting standards, as applicable, and this Agreement, the sums or credits due under this
Agreement, including Joint Development Costs incurred through Effective Date and Net Sales. All such books, records and accounts shall be retained by such Party until the later of (a) three (3) years after the end of the period to which
such books, records and accounts pertain and (b) the expiration of the applicable tax statute of limitations (or any extensions thereof), or for such longer period as may be required by applicable Laws. Each Party shall require its sublicensees
to provide to it a report detailing the foregoing expenses and calculations incurred or made by such sublicensee, which report shall be made available to the other Party in connection with any audit conducted by such other Party pursuant to
Section 7.9. 
 7.9 Audits. Each Party shall have the right to have an independent certified public
accountant, reasonably acceptable to the audited Party, have access during normal business hours, and upon reasonable prior written notice, to examine only those records of the audited Party (and its Affiliates and sublicensees) as may be reasonably
necessary to determine, with respect to any calendar year ending not more than three (3) years prior to such Party’s request, the correctness or completeness of any report or payment made under this Agreement. The foregoing right of review
may be exercised only once per year and only once with respect to each such periodic report and payment. Reports of the results of any such examination shall be (a) limited to details of any discrepancies in the audited Party’s records
relating to the Product, (b) made available to both Parties and (c) subject to Article 11.If the audit report concludes that (i) additional amounts were owed by the audited Party, the audited Party shall pay the additional amounts,
with interest from the date originally due as provided in Section 7.7 or (ii) excess payments were made by the audited Party, the auditing Party shall reimburse such excess payments, with interest from the date when the original payment
was made, in either case ((i) or (ii)), within [***] after the date on which such audit report is delivered to both Parties. The Party requesting the audit shall bear the full cost of the performance of any such audit, unless such audit, which
covers the entire calendar year, discloses a variance to the detriment of the auditing Party of more than [***] from the amount of the original report, royalty or payment calculation, in which case the audited Party shall bear the full cost of the
performance of such audit. The results of such audit shall be final, absent manifest error. 

  
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 7.10 Taxes. 

(a) Taxes on Income. Each Party shall be solely responsible for the payment of all taxes imposed on its share of income arising
directly or indirectly from the efforts of the Parties under this Agreement. 
 (b) Tax Cooperation. The Parties
agree to cooperate with one another and use reasonable efforts to reduce or eliminate tax withholding or similar obligations in respect of royalties, milestone payments, and other payments made by one Party to the other Party under this Agreement.
To the extent a Party is required to deduct and withhold taxes on any payment to the other Party, it shall pay the amounts of such taxes to the proper Governmental Authority in a timely manner and promptly transmit to the other Party an official tax
certificate or other evidence of such withholding sufficient to enable the other Party to claim such payment of taxes. The other Party shall provide the deducting Party any tax forms that may be reasonably necessary in order for it not to withhold
tax or to withhold tax at a reduced rate under an applicable bilateral income tax treaty. Each Party shall provide the other with reasonable assistance to enable the recovery, as permitted by applicable Laws, of withholding taxes, value added taxes,
or similar obligations resulting from payments made under this Agreement, such recovery to be for the benefit of the Party bearing such withholding tax or value added tax. Mundipharma shall require its Sublicensees in the Licensed Territory to
cooperate with Allos in a manner consistent with this Section 7.10(b). 
 (c) Mundipharma Payments.

 (i) Taxes Resulting From Mundipharma Action. If Mundipharma is required to make a payment to Allos that is subject to
a deduction or withholding of tax, then (A) if such withholding or deduction obligation arises as a result of any action by Mundipharma, including any assignment or sublicense, any performance by a Mundipharma Affiliate (pursuant to
Section 14.6), or any failure on the part of Mundipharma to comply with applicable Laws or filing or record retention requirements, that has the effect of modifying the tax treatment of the Parties hereto (a “Mundipharma
Payment-Mundipharma Withholding Tax Action”), then the sum payable by Mundipharma (in respect of which such deduction or withholding is required to be made) shall be increased to the extent necessary to ensure that Allos receives a
sum equal to the sum which it would have received had no such Mundipharma Payment-Mundipharma Withholding Tax Action occurred, and (B) otherwise, the sum payable by Mundipharma (in respect of which such deduction or withholding is required to
be made) shall be made to Allos after deduction of the amount required to be so deducted or withheld, which deducted or withheld amount shall be remitted to the proper Governmental Authority in accordance with applicable Laws. If Allos subsequently
receives a refund of any of the tax deducted by Mundipharma pursuant to (A) above, it shall pay such refunded amount to Mundipharma within [***] of receipt. 
 (ii) Taxes Resulting From Allos Action. If Mundipharma is required to make a payment to Allos that is subject to a deduction or withholding of tax, then if such
withholding or deduction obligation arises as a result of any action by Allos, including any assignment or sublicense, any performance by an Allos Affiliate (pursuant to Section 14.6), or any failure on the part of Allos to comply with
applicable Laws or filing or record retention requirements, that has the  

  
 [***]: CONFIDENTIAL
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effect of modifying the tax treatment of the Parties hereto (a “Mundipharma Payment-Allos Withholding Tax Action”), then Mundipharma shall be under no obligation to
increase the sum payable by Mundipharma (in respect of which such deduction or withholding is required to be made) and the sum payable by Mundipharma shall be net of any withholding obligations resulting from such Mundipharma Payment-Allos
Withholding Tax Action. 
 (d) Allos Payments. 

(i) Taxes Resulting From Allos Action. If Allos is required to make a payment to Mundipharma that is subject to a deduction
or withholding of tax, then (A) if such withholding or deduction obligation arises as a result of any action by Allos, including any assignment or sublicense, any performance by an Allos Affiliate (pursuant to Section 14.6), or any failure
on the part of Allos to comply with applicable Laws or filing or record retention requirements, that has the effect of modifying the tax treatment of the Parties hereto (an “Allos Payment-Allos Withholding Tax Action”), then the sum
payable by Allos (in respect of which such deduction or withholding is required to be made) shall be increased to the extent necessary to ensure that Mundipharma receives a sum equal to the sum which it would have received had no such Allos
Payment-Allos Withholding Tax Action occurred, and (B) otherwise, the sum payable by Allos (in respect of which such deduction or withholding is required to be made) shall be made to Mundipharma after deduction of the amount required to be so
deducted or withheld, which deducted or withheld amount shall be remitted to the proper Governmental Authority in accordance with applicable Laws. If Mundipharma subsequently receives a refund of any of the tax deducted by Allos pursuant to
(A) above, it shall pay such refunded amount to Allos within [***] of receipt. 
 (ii) Taxes Resulting From Mundipharma
Action. If Allos is required to make a payment to Mundipharma that is subject to a deduction or withholding of tax, then if such withholding or deduction obligation arises as a result of any action by Mundipharma, including any assignment
or sublicense, any performance by a Mundipharma Affiliate (pursuant to Section 14.6), or any failure on the part of Mundipharma to comply with applicable Laws or filing or record retention requirements, that has the effect of modifying the tax
treatment of the Parties hereto (an “Allos Payment-Mundipharma Withholding Tax Action”), then Allos shall be under no obligation to increase the sum payable by Allos (in respect of which such deduction or withholding is required to
be made) and the sum payable by Allos shall be net of any withholding obligations resulting from such Allos Payment-Mundipharma Withholding Tax Action. 
 ARTICLE 8 
 INTELLECTUAL PROPERTY MATTERS 

8.1 Ownership of Inventions. Each Party shall own any inventions, whether or not patentable, made solely by its own employees,
agents, or independent contractors in the course of conducting its activities under this Agreement, together with all intellectual property rights therein (“Sole Inventions”). The Parties shall jointly own any inventions that are
made jointly by employees, agents, or independent contractors of each Party in the course of performing activities under this Agreement, together with all intellectual property rights therein (“Joint Inventions”).

  
 [***]: CONFIDENTIAL
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Inventorship as between the Parties shall be determined in accordance with U.S. patent laws. All Patents claiming Joint Inventions shall be referred to herein as “Joint
Patents”. Except to the extent either Party is restricted by the licenses granted to the other Party under this Agreement or the other terms of this Agreement, each Party shall be entitled to practice and exploit the Joint Inventions
and Joint Patents without the duty of accounting or seeking consent from the other Party. 
 8.2 Disclosure of Inventions;
Patent Strategy Consultation. Each Party shall use reasonable best efforts to promptly disclose to the other Party all Sole Inventions and Joint Inventions, including any invention disclosures, or other similar documents, submitted to it
by its employees, agents or independent contractors describing inventions that are either Sole Inventions or Joint Inventions, and all Information relating to such inventions to the extent necessary or useful for the preparation, filing and
maintenance of any Patent with respect to such invention. From time to time, the Parties, through their respective patent practitioners or at meetings of the JPC, shall advise each other and consult regarding the patent strategy for the Allos
Prosecuted Patents. 
 8.3 Prosecution of Patents. 

(a) Subject to Section 8.3(b), as between the Parties, Allos shall have the sole right to prepare, file, prosecute and
maintain Allos Patents, Joint Patents and Mundipharma Patents (collectively, the “Allos Prosecuted Patents”). As between the Parties, [***] shall bear all costs incurred by Allos in connection with the preparation, filing,
prosecution or maintenance of any Allos Prosecuted Patents in the Allos Territory and Mundipharma shall bear all costs incurred by Allos in connection with the preparation, filing, prosecution or maintenance of any Allos Prosecuted Patents in the
Licensed Territory. Prior to any filing or extension, Allos shall provide Mundipharma reasonable opportunity to review and comment on such prosecution efforts regarding the Allos Prosecuted Patents (including the PDX Patents, to the extent the PDX
Licensor consults with Allos and provides Allos the right to review and comment on the same, in each case as is required pursuant to section 8.2 of the PDX License Agreement) as follows: Allos shall promptly provide Mundipharma with copies of all
material communications from any patent authority regarding the Allos Prosecuted Patents, and shall provide Mundipharma, for its review and comment, with drafts of any material filings or responses to be made to such patent authorities in a
reasonable amount of time in advance of submitting such filings or responses. Allos shall include any reasonable comments thereto provided by Mundipharma in connection with the prosecution of the Allos Prosecuted Patents. Each Party shall provide
the other Party all reasonable assistance and cooperation in the patent prosecution efforts provided in this Section 8.3(a), including executing any other required documents or instruments for such prosecution. 

(b) Except with respect to the PDX Patents, if Allos decides anywhere in the Licensed Territory to abandon any Allos Prosecuted
Patent or not to apply for an extension of any Allos Prosecuted Patent, including a supplementary protection certificate or equivalent thereof, Mundipharma shall have the right to assume Allos’ rights and responsibilities under this
Section 8.3 with respect to such Allos Prosecuted Patent, and in connection with assuming such rights and responsibilities, Mundipharma shall be entitled to apply for any such extension (including a supplementary protection certificate or
equivalent thereof) and Mundipharma shall thereafter become responsible for the prosecution and maintenance of such Allos Prosecuted Patent in the Licensed 

  
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Territory. With respect to any PDX Patent, the foregoing shall apply only if and to the extent that Allos assumes responsibility and control (after consultation with Mundipharma as to whether to
assume such responsibility or control) of the prosecution and maintenance of such PDX Patent in accordance with the PDX License Agreement. 
 8.4 Patent Enforcement in the Licensed Territory. 
 (a)
Notification. If either Party become aware of any existing or threatened infringement of the Allos Patents, Joint Patents or Mundipharma Patents in the Field in the Licensed Territory by a Third Party (“Licensed Territory
Infringement”), it shall promptly notify the other Party in writing to that effect and the Parties will consult with each other regarding any actions to be taken with respect to such Licensed Territory Infringement. 

(b) Enforcement Rights. For any Licensed Territory Infringement, each Party shall share with the other Party all Information
available to it regarding such actual or alleged infringement. As between the Parties, Mundipharma shall have the first right, but not the obligation, to bring an appropriate suit or other action against any person or entity engaged in such Licensed
Territory Infringement, at Mundipharma’s cost and expense. Mundipharma shall have a period of ninety (90) days after its receipt or delivery of notice under Section 8.4(a) to elect to so enforce the Joint Patents, Allos Patents or
Mundipharma Patents against such Licensed Territory Infringement (or to settle or otherwise secure the abatement of such Licensed Territory Infringement). If Mundipharma fails to commence a suit to enforce the applicable Joint Patents, Allos Patents
or Mundipharma Patents against such Licensed Territory Infringement or to settle or otherwise secure the abatement of such Licensed Territory Infringement within such period, then Allos shall have the right, but not the obligation, to commence a
suit or take action to enforce such Joint Patents, Allos Patents or Mundipharma Patents against such Licensed Territory Infringement at its own cost and expense. In this case, Mundipharma shall take appropriate actions in order to enable Allos to
commence a suit or take the actions set forth in the preceding sentence. If neither Mundipharma nor Allos commences a suit or takes action to enforce the PDX Patents, the PDX Licensor may elect to take such enforcement action. 

(c) Collaboration. Each Party shall provide to the enforcing Party reasonable assistance in such enforcement, at such enforcing
Party’s request and expense, including joining such action as a party plaintiff if required by applicable Laws to pursue such action. The enforcing Party shall keep the other Party regularly informed of the status and progress of such
enforcement efforts, shall reasonably consider the other Party’s comments on any such efforts, and shall seek consent of the other Party in any important aspects of such enforcement, including determination of litigation strategy and filing of
material papers to the competent court, which shall not be unreasonably withheld, conditioned or delayed. The non-enforcing Party shall be entitled to separate representation in such matter by counsel of its own choice and at its own expense, but
such Party shall at all times cooperate fully with the enforcing Party. 
 (d) Settlement. 

(i) Mundipharma shall not settle any claim, suit or action that it brought under Section 8.4(b) in any manner that would
negatively impact the applicable Allos Patents, Joint Patents or Mundipharma Patents or that would limit or restrict the ability of Allos to Develop, make, use, import, offer for sale, sell or otherwise Commercialize Products anywhere in the Field
in the Allos Territory or to make or have made Products anywhere in the world, without the prior written 

  
 49 

 
consent of Allos, which consent shall not be unreasonably withheld, conditioned or delayed. Nothing in this Article 8 shall require Allos to consent to any settlement that is reasonably
anticipated by Allos to have a substantially adverse impact upon any Allos Patent, Joint Patent or Mundipharma Patent in the Allos Territory, or to the Development, Commercialization, use, importation, offer for sale or sale of Products in the Field
in the Allos Territory, or to the manufacture of Products anywhere in the world. 
 (ii) Allos shall not settle any
claim, suit or action that it brought under Section 8.4(b) in any manner that would negatively impact the applicable Allos Patents, Joint Patents or Mundipharma Patents or that would limit or restrict the ability of Mundipharma to Develop,
make, use, import, offer for sale, sell or otherwise Commercialize Products anywhere in the Licensed Territory in the Field, without the prior written consent of Mundipharma, which consent shall not be unreasonably withheld, conditioned or delayed.
Nothing in this Article 8 shall require Mundipharma to consent to any settlement that is reasonably anticipated by Mundipharma to have a substantially adverse impact upon any Allos Patent, Joint Patent or Mundipharma Patent in the Licensed
Territory, or to the Development, manufacture, Commercialization, use, importation, offer for sale or sale of Products in the Licensed Territory in the Field. 
 (e) Expenses and Recoveries. The enforcing Party bringing a claim, suit or action under Section 8.4(b) shall be solely responsible for any expenses incurred by such Party as a result of
such claim, suit or action. If such Party recovers monetary damages in such claim, suit or action, such recovery shall be allocated first to the reimbursement of any expenses incurred by the Parties in such litigation, and any remaining amounts
shall be retained by the Party bringing suit, provided that, in the event Mundipharma is the Party bringing suit, such remaining amounts shall be deemed Net Sales and Mundipharma shall make a royalty payment to Allos with respect thereto in
accordance with Section 7.4(a). 
 8.5 Patent Enforcement in the Allos Territory. 

(a) Notification. If either Party becomes aware of any existing or threatened infringement of the Allos Patents, Joint
Patents or Mundipharma Patents in the Field in the Allos Territory by a Third Party (“Allos Territory Infringement”), it shall promptly notify the other Party in writing to that effect and the Parties will consult with
each other regarding any actions to be taken with respect to such Infringement. 
 (b) Enforcement Rights. For any
Allos Territory Infringement, each Party shall share with the other Party all Information available to it regarding such actual or alleged infringement. Allos shall have the sole right, but not the obligation, to bring an appropriate suit or other
action against any person or entity engaged in such Allos Territory Infringement, at Allos’ cost and expense, if such Allos Territory Infringement involves only Allos Patents. As between the Parties, Allos shall have the first right, but not
the obligation, to bring an appropriate suit or other action against any person or entity engaged in such Allos Territory Infringement, at Allos’ cost and expense, if such Allos Territory Infringement involves Joint Patents or Mundipharma
Patents. Allos shall have a period of ninety (90) days after its receipt or delivery of notice under Section 8.5(a) to elect to so enforce the Joint Patents or Mundipharma Patents against such Allos Territory Infringement (or to settle or
otherwise secure the abatement of such Allos Territory Infringement). If Allos fails to commence a suit to enforce the applicable Joint Patents or Mundipharma Patents against such Allos Territory Infringement or to settle or otherwise secure the
abatement of such Allos Territory Infringement within such period, then Mundipharma shall have the right, but not the 

  
 50 

 
obligation, to commence a suit or take action to enforce such Joint Patents or Mundipharma Patents against such Allos Territory Infringement at its own cost and expense. In this case, Allos shall
take appropriate actions in order to enable Mundipharma to commence a suit or take the actions set forth in the preceding sentence. If neither Allos nor Mundipharma commences a suit or takes action to enforce the PDX Patents, the PDX Licensor may
elect to take such enforcement action. 
 (c) Collaboration. Each Party shall provide to the enforcing Party reasonable
assistance in such enforcement, at such enforcing Party’s request and expense, including joining such action as a party plaintiff if required by applicable Laws to pursue such action. The enforcing Party shall keep the other Party regularly
informed of the status and progress of such enforcement efforts, shall reasonably consider the other Party’s comments on any such efforts, and shall seek consent of the other Party in any important aspects of such enforcement, including
determination of litigation strategy and filing of material papers to the competent court, which shall not be unreasonably withheld, conditioned or delayed. The non-enforcing Party shall be entitled to separate representation in such matter by
counsel of its own choice and at its own expense, but such Party shall at all times cooperate fully with the enforcing Party. 

(d) Settlement. Allos shall not settle any claim, suit or action that it brought under Section 8.5(b) in any manner that would
negatively impact the applicable Joint Patents or Mundipharma Patents or that would limit or restrict the ability of Mundipharma to Develop, make, use, import, offer for sale, sell or otherwise Commercialize Products anywhere in the Licensed
Territory, without the prior written consent of Mundipharma, which consent shall not be unreasonably withheld, conditioned or delayed. Nothing in this Article 8 shall require Mundipharma to consent to any settlement that is reasonably anticipated by
Mundipharma to have a substantially adverse impact upon any Joint Patent or Mundipharma Patent, or to the Development, Commercialization, use, importation, offer for sale or sale of Products in the Licensed Territory. 

(e) Expenses and Recoveries. The enforcing Party bringing a claim, suit or action under Section 8.5(b) shall be solely responsible
for any expenses incurred by such Party as a result of such claim, suit or action. If such Party recovers monetary damages in such claim, suit or action, such recovery shall be allocated first to the reimbursement of any expenses incurred by the
Parties in such litigation, and any remaining amounts shall be retained by the Party bringing suit. 
 8.6 PDX
Patents. Each Party’s rights under this Article 8 with respect to the prosecution, maintenance and enforcement of any PDX Patent shall be subject to the rights of the PDX Licensor to prosecute, maintain and enforce such PDX Patent.
Notwithstanding the foregoing, Allos shall provide Mundipharma reasonable opportunity to review and comment on prosecution efforts regarding the PDX Patents to the extent the PDX Licensor consults with Allos and provides Allos the right to review
and comment on the same, in each case as is required pursuant to section 8.2 of the PDX License Agreement. 
 8.7 Infringement
of Third Party Rights in the Licensed Territory. Subject to Article 10, if a Product used or sold by Mundipharma, its Affiliates or Sublicensees becomes the subject of a Third Party’s claim or assertion of infringement of a Patent granted
by a jurisdiction within the Licensed Territory (each such claim or assertion a “Third Party Claim”), Mundipharma shall promptly notify Allos and the Parties shall agree on and enter into a common interest agreement, pursuant to
which the Parties will agree to work toward their shared, mutual interest in the outcome of such potential dispute, and thereafter, the Parties shall promptly meet to consider the Third Party Claim and the appropriate course of action. Mundipharma
shall be solely responsible for the defense of any such Third Party Claim, at Mundipharma’s cost and expense; provided that the provisions of Section 8.4 shall govern the right of Mundipharma to assert a counterclaim of infringement of any
Allos Patents, Joint Patents or Mundipharma Patents. 

  
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 8.8 Patent Marking. Mundipharma and its Affiliates and Sublicensees shall mark
any Product marketed and sold by Mundipharma or its Affiliates or Sublicensee hereunder with appropriate patent numbers or indicia; provided, however, that Mundipharma shall only be required to so mark such Product to the extent such
markings or such notices would affect recoveries of damages or equitable remedies available under applicable Laws with respect to infringement of Patents in the Licensed Territory. 

8.9 Trademark Matters. 
 (a) Trademark License. Subject to the terms and conditions of this Agreement, Allos hereby grants to Mundipharma an exclusive, royalty-free right and license, with the right to sublicense
solely as provided in Section 8.9(b), to use the trademarks set forth on Exhibit B (the “Licensed Marks”) solely in connection with the Commercialization of Products in the Field in the Licensed Territory.

 (b) Sublicense Rights. Mundipharma shall have the right to grant sublicenses of the license granted in
Section 8.9(a) solely to a Sublicensee that has received a sublicense from Mundipharma of the license granted to Mundipharma in Section 2.1(b). Such sublicense shall be included in the applicable Mundipharma Sublicense Agreement, which
shall obligate such Sublicensee to comply with the terms and conditions of Section 8.9(c) through 8.9(f), Section 8.9(h) and Section 8.9(j) as if such Sublicensee were Mundipharma. 

(c) Ownership of the Licensed Marks. Mundipharma agrees and acknowledges that it has no interest, right, or title in the
Licensed Marks other than the license granted in Section 8.9(a) and that it will not obtain any rights in or to the Licensed Marks through its use in connection with the Products. Mundipharma further agrees that Allos is and will continue to be
the sole and exclusive owner of all rights, title and interest in and to each Licensed Mark in any form or embodiment thereof and agrees that all goodwill associated with or attached to the Licensed Marks arising out of the use thereof by
Mundipharma shall inure to the benefit of Allos. 
 (d) Registration; No Contest. Allos has registered, or has
filed applications for registration of, the Licensed Marks in those countries and jurisdictions in the Licensed Territory indicated in Exhibit B. Upon the written request of Mundipharma, Allos will register or attempt to register the Licensed
Marks in such other countries in the Licensed Territory in which Mundipharma reasonably expects to file a Drug Approval Application and seek to obtain Regulatory Approval. Mundipharma agrees that it will neither contest, oppose or challenge, nor
assist any party in contesting, opposing or challenging, Allos’ ownership of the Licensed Marks or the distinctiveness or validity of the Licensed Marks. Mundipharma agrees that it will not at any time do or suffer to be done any act or thing
that will in any way impair Allos’ ownership of or rights in and to the Licensed Marks or any registration thereof. Mundipharma will not register or attempt to register any Licensed Mark in any jurisdiction nor oppose Allos’ registration
of any Licensed Mark, alone or with other words or designs, in any jurisdiction; provided, however, Mundipharma shall have the right to register as domain names the Licensed Marks in any country in the Licensed Territory using any
country code domain names for such country, but specifically excluding the domain names set forth in the Letter Agreement. Mundipharma shall, on the reasonable request of Allos, give Allos or its

  
 52 

 
authorized representative necessary information as to the use of the Licensed Marks pursuant to this Agreement which Allos may require and will render any assistance reasonably required by Allos
in obtaining or maintaining the registrations of the Licensed Marks. Any costs incurred by Mundipharma in rendering such assistance shall be [***]. 
 (e) Compliance. The Licensed Marks may only be used on Products that are Commercialized in the Field in the Licensed Territory in accordance with applicable Law and current pharmaceutical
industry standards of quality, including the terms of all applicable Regulatory Approvals. 
 (f) Use of the Licensed
Marks. Mundipharma agrees to comply with all applicable Laws pertaining to the proper use and designation of the Licensed Marks. Additionally, Mundipharma shall: 
 (i) use the Licensed Marks upon or in relation to the Products only in such manner that the distinctiveness, reputation, and validity of the Licensed Marks shall not be impaired. Without prejudice
to the generality of the foregoing, Mundipharma shall use Reasonably Diligent Efforts to ensure in particular that each Licensed Mark is correctly spelled, is accompanied by words accurately describing the nature of the goods or services to which it
relates, and is displayed as set forth in Exhibit B and that any text, graphics or designs adjacent to any Licensed Mark does not put the Licensed Mark or Allos in a negative or derogatory light; 

(ii) comply with the reasonable requirements of Allos as to the form, manner, scale and context of use of the Licensed Marks, and
the use of the statements to accompany them; 
 (iii) the first time Mundipharma plans to use a particular Licensed Mark,
provide Allos with samples of the proposed packaging and related marketing and promotional materials to be used for the Products. Mundipharma shall consider in good faith any comments Allos may make regarding same; 

(iv) display the proper form of trademark and service mark notice associated with the Licensed Marks in accordance with reasonable
instructions received from Allos; 
 (v) include, on any item which bears a Licensed Mark, a statement identifying Allos
as the owner of such Licensed Mark and stating that Mundipharma is an authorized user of such Licensed Mark; 
 (vi) not
conduct, without the written consent of Allos, the whole or any part of its business under a business name or trading style which incorporates any of the Licensed Marks or which might materially impair the validity, reputation or distinctiveness of
any of the Licensed Marks; and 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 53 

 (vii) neither use nor display any of the Licensed Marks in such relation to any
other mark or marks owned by any Third Party or Mundipharma so as to suggest that the multiple marks constitute a single or composite trademark, service mark, or are under the same proprietorship. 

(g) Out-of-Pocket Costs. All out-of-pocket expenses incurred by Allos in connection with pursuit of registration and
maintenance of registered Licensed Marks in the Licensed Territory during the Term, including in connection with filing of necessary maintenance and use documents, applying for renewal, and payment of any required taxes or fees due in connection
with such applications or registrations, shall be [***]. 
 (h) Quality Control. The nature and quality of the
Products, and all advertising and promotional uses of the Licensed Marks by Mundipharma, shall conform to or exceed industry standards for products similar to the Products. Mundipharma shall, and shall at the request of Allos or its authorized
representative, furnish at Mundipharma’s expense such samples of the Products for inspection and analysis as may reasonably be requested. 
 (i) Enforcement of Licensed Marks. 
 (A) If either Party or
its Affiliate becomes aware of actual or threatened infringement in the Licensed Territory of any Licensed Mark or of a mark or name confusingly similar to any Licensed Mark, such Party shall promptly notify the other Party in writing. Mundipharma
shall have the first right, but not the obligation, to bring infringement or unfair competition actions in the Licensed Territory involving a Licensed Mark. Allos shall, at the request and expense of Mundipharma, cooperate and provide reasonable
assistance in any action described in this Section 8.9(i)(A) and, if required by Law, join such action. Mundipharma shall bear the entire cost and expense associated with such action, and any recovery resulting from such proceeding shall belong
entirely to Mundipharma. However, Mundipharma shall not settle or accept any settlement from any Third Party in connection with the adverse use of any Licensed Mark without the prior written consent of Allos (such consent not to be unreasonably
withheld, conditioned or delayed). 
 (B) If Mundipharma fails to terminate such threatened or actual infringement or to
bring and diligently prosecute an infringement or unfair competition action to terminate such threatened or actual infringement within ninety (90) days of notice pursuant to Section 8.9(i)(A), Allos may thereafter take such action as it
deems appropriate, including bringing, at its own expense, an infringement action or filing any other appropriate action or claim related to infringement of the Licensed Mark in the Licensed Territory against any Third Party. Mundipharma shall, at
the request and expense of Allos, cooperate and provide reasonable assistance in any action described in this Section 8.9(i)(B) and, if required by Law, join such action. Allos shall bear the entire cost and expense associated with such action,
and any recovery resulting from such proceeding shall belong entirely to Allos. 
 (j) Third Party Trademark
Litigation. In the event of the initiation of any suit by a Third Party against Mundipharma for trademark infringement involving Commercialization of Products in the Field in the Licensed Territory, Mundipharma shall promptly notify Allos
in writing. Mundipharma shall have the right, but not the obligation, to defend such suit at its expense. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 54 

 (k) Alternative Trademark. If (x) any of the events set forth in
Section 12.5(i)-(vi) shall have occurred with respect to Allos, (y) a Regulatory Authority in any country in the Licensed Territory refuses to permit Mundipharma to use a Licensed Mark in connection with the Commercialization of
Products in such country, or a Licensed Mark is found by a court of competent jurisdiction to infringe Third Party rights in such country, or (z) if Mundipharma determines in good faith that such Licensed Mark is not commercially viable in any
country in the Licensed Territory and Allos reasonably agrees in writing (not to be unreasonably withheld, conditioned or delayed), then Mundipharma may use an alternative trademark owned by Mundipharma and approved by the JPC, in lieu of such
Licensed Mark, in connection with the Commercialization of Products in such country. 
 (l) Assignment. As of the
Original Effective Date, Allos transferred and assigned to Mundipharma, its successors and assigns, Allos’ entire ownership interest and title in the trademark [***], for use in connection with Commercializing Products in the Field in the
Licensed Territory (as defined in the Original Agreement), together with any and all goodwill assigned therewith, to be held and enjoyed by Mundipharma, its successors and assigns, to the full end of the term thereof, as may be extended by Law as
fully and entirely as the same would have been held and enjoyed by Allos if this transfer and assignment had not been made. From and after the date of such assignment, Mundipharma agreed to pay all of the out-of-pocket costs and expenses associated
with registering and maintaining the [***] trademark in the Licensed Territory. The Parties executed and delivered, within [***] after the Original Effective Date, a trademark assignment agreement (or confirmation of trademark assignment) reflecting
the terms set forth in this Section 8.9(l). Mundipharma hereby transfers and assigns to Allos, its successors and assigns, Mundipharma’s entire ownership interest and title in the trademark [***], for use in connection with Commercializing
Products in the Field in the European Countries and Turkey, together with any and all goodwill assigned therewith, to be held and enjoyed by Allos, its successors and assigns, to the full end of the term thereof, as may be extended by Law as fully
and entirely as the same would have been held and enjoyed by Mundipharma if this transfer and assignment had not been made. From and after the Effective Date, Allos shall pay all of the out-of-pocket costs and expenses associated with registering
and maintaining the [***] trademark in the European Countries and Turkey. The Parties agree to execute and deliver, within [***] after the Effective Date, a trademark assignment agreement (or confirmation of trademark assignment) reflecting the
transfer back of the ownership rights from Mundipharma to Allos as set forth in this Section 8.9(l). The Parties shall coordinate use of the [***] trademark in their respective Commercialization activities between the Allos Territory and the
Licensed Territory as part of their territorial coordination pursuant to Section 6.8. 
 (m) Coexistence
Agreements. The Parties agree that, to the extent necessary or advisable, Mundipharma may request that Allos enter into one or more coexistence agreements with Third Parties in respect of trademarks that such Third Parties own and/or
utilize in the Licensed Territory, that are confusingly or otherwise substantially similar to the Licensed Mark. Allos agrees to cooperate with Mundipharma and provide such reasonable and timely assistance, at Mundipharma’s expense, as
Mundipharma may require in order that Allos and each such Third Party may consummate an appropriate coexistence agreement. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
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 ARTICLE 9 
 REPRESENTATIONS AND WARRANTIES; COVENANTS 
 9.1 Mutual Representations
and Warranties. Each Party hereby represents and warrants to the other Party as follows: 
 (a) Corporate
Existence. As of the Original Effective Date, and as of the Effective Date, it is a corporation duly organized, validly existing, and in good standing under the Laws of the jurisdiction in which it was incorporated; 

(b) Corporate Power, Authority and Binding Agreement. As of the Original Effective Date, and as of the Effective Date, (i) it
has the corporate power and authority and the legal right to enter into this Agreement and perform its obligations hereunder; (ii) it has taken all necessary corporate action on its part required to authorize the execution and delivery of this
Agreement and the performance of its obligations hereunder; and (iii) this Agreement has been duly executed and delivered on behalf of such Party, and constitutes a legal, valid, and binding obligation of such Party that is enforceable against
it in accordance with its terms, subject to enforcement of remedies under applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting generally the enforcement of creditors’ rights and subject to a court’s
discretionary authority with respect to the granting of a decree ordering specific performance or other equitable remedies; 
 (c) No Conflict. To such Party’s Knowledge, the execution and delivery of this Agreement, the performance of such Party’s obligations in the conduct of the Development Plan or the Allos
Required Studies Schedule, as applicable, and the licenses and sublicenses to be granted pursuant to this Agreement (i) do not and will not conflict with or violate any requirement of applicable Law existing as of the Original Effective Date,
and as of the Effective Date; (ii) do not and will not conflict with or violate the certificate of incorporation or by-laws of such Party; and (iii) do not and will not conflict with, violate, breach or constitute a material default under
any contractual obligations of such Party or any of its Affiliates existing as of the Original Effective Date, and as of the Effective Date; 
 (d) Other Rights. Neither Party nor any of their respective Affiliates is a party to or otherwise bound by any oral or written contract or agreement, other than the PDX License Agreement (only as
it relates to Allos), that will result in any other person obtaining any interest in, or that would give to any other person any right to assert any claim in or with respect to, any of such Party’s rights under this Agreement;

 (e) No Violation. Neither Party nor any of their respective Affiliates is under any obligation to any person,
contractual or otherwise, that is in violation of the terms of this Agreement or that would impede the fulfillment of such Party’s obligations hereunder; and 
 (f) No Debarment. As of the Original Effective Date, and as of the Effective Date, none of such Party’s employees or consultants: 

(i) is debarred under Section 306(a) or 306(b) of the FD&C Act or by the analogous Laws of any Regulatory Authority;

  
 56 

 (ii) has, to such Party’s Knowledge, been charged with, or convicted of, any
felony or misdemeanor within the ambit of 42 U.S.C. §§ 1320a-7(a), 1320a-7(b)(l)-(3), or pursuant to the analogous Laws of any Regulatory Authority, or is proposed for exclusion, or the subject of exclusion or debarment proceedings by a
Regulatory Authority; and 
 (iii) is excluded, suspended or debarred from participation, or otherwise ineligible to
participate, in any U.S. or non-U.S. health care programs (or has been convicted of a criminal offense that falls within the scope of 42 U.S.C. §1320a-7 but not yet excluded, debarred, suspended, or otherwise declared ineligible), or excluded,
suspended or debarred by a Regulatory Authority from participation, or otherwise ineligible to participate, in any procurement or nonprocurement programs. 
 9.2 Additional Representations and Warranties of Allos. Allos represents and warrants to Mundipharma as follows, as of the Original Effective Date, and as of the Effective Date: 

(a) Title; Encumbrances. It has (i) sufficient legal and/or beneficial title, ownership or license, free and clear from any
mortgages, pledges, liens, security interests, options, conditional and installment sale agreements, encumbrances, charges or claims of any kind, of or to the Allos Technology or the Allos Manufacturing Know-How or the Allos ISS Technology to grant
the licenses to Mundipharma as purported to be granted pursuant to this Agreement; and (ii) to Allos’ Knowledge, no Third Party (other than the PDX Licensor) has taken any action before the United States Patent and Trademark Office, or any
counterpart thereof outside the U.S., claiming legal and/or beneficial ownership of or license to any of the Allos Patents; 
 (b) PDX License Agreement. Allos is not in material breach of the PDX License Agreement, and has not received any notices from the PDX Licensor of any breaches of the PDX License Agreement within
the last three (3) years; 
 (c) Amendments to the PDX License Agreement. There have been no amendments to the PDX
License Agreement from and after the Original Effective Date. 
 (d) Notice of Infringement or Misappropriation. It
has not received any written notice from any Third Party asserting or alleging that (i) any research, Development, manufacture or Commercialization of the Product by Allos prior to the Effective Date infringed or misappropriated the
intellectual property rights of such Third Party or (ii) the exercise of Mundipharma’s rights granted under this Agreement infringes or would infringe any Third Party intellectual property rights; 

(e) Non-Infringement of Third Party Rights. To Allos’ Knowledge, without any investigation, the Development, manufacture and
Commercialization of the Product can be carried out in the manner reasonably contemplated as of the Original Effective Date, and as of the Effective Date, without infringing any issued patents owned or controlled by a Third Party; 

(f) Non-Infringement of Rights by Third Parties. To Allos’ Knowledge, without any investigation, no Third Party is infringing
or has infringed the Allos Technology or the Allos ISS Technology or is misappropriating the Allos Manufacturing Know-How existing as of the Original Effective Date, and as of the Effective Date; 

  
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 (g) Non-Assertion by Third Parties. To Allos’ Knowledge, no Third Party has
asserted in writing that the issued patents within the Allos Patents set forth in Schedule 1 are invalid or unenforceable in the Licensed Territory or the Allos Territory; 

(h) No Proceeding. There are no pending, and to Allos’ Knowledge, no threatened, adverse actions, claims, investigations,
suits or proceedings against Allos or any of its Affiliates, at Law or in equity, or before or by any Governmental Authority, involving the Allos Technology or the Product, nor to Allos’ Knowledge has any such adverse action, claim,
investigation, suit or proceeding been brought or threatened during the past three (3) years, in each case, which has been resolved in a manner that materially impairs any of Allos’ rights in and to any such Allos Technology or to the
Product; 
 (i) No Consents. No authorization, consent, approval of a Third Party, other than the PDX Licensor, nor to
Allos’ Knowledge, any license, permit, exemption of or filing or registration with or notification to any court or Governmental Authority is or will be necessary for the (i) valid execution and delivery of this Agreement by Allos;
(ii) the consummation by Allos of the transactions contemplated hereby; or (iii) prevention of the termination of any right, privilege, license or agreement relating to the Allos Technology or the continuation thereof following the
Original Effective Date; 
 (j) No Non-Competition Agreements. Neither Allos nor any of its Affiliates are bound by
any non-competition agreements related to the Product; provided that Allos and its Affiliates are parties to license agreements with respect to certain other products for same or overlapping indications as the Product, which may cause diversion of
resources but shall not be deemed to be non-competition agreements related to the Product; 
 (k) Compliance with
Laws. To Allos’ Knowledge, Allos has complied with all applicable Laws in connection with Allos’ prosecution of the Allos Patents other than the PDX Patents, including the duty of candor owed to any patent office pursuant to such
Laws; 
 (l) No Grant of Rights. Allos has not granted any rights with respect to the Product, the Allos
Technology, the Allos Manufacturing Know-How and/or the Allos ISS Technology in the Licensed Territory, in each case, to any person or entity other than Mundipharma, except pursuant to the PDX License Agreement or contracts with Third Parties in
connection with, and for the purpose of, the development and/or manufacture of the Product for or on behalf of Allos and in connection with any named patient supply program; 

(m) No Unauthorized Use. Neither Allos nor any of its Affiliates has received any written notice of any unauthorized use,
infringement, misappropriation, or dilution by any person, including any current or former employee or consultant of Allos or its Affiliates, of the Product or of any of the Allos Technology or the Allos Manufacturing Know-How or the Allos ISS
Technology, except as would not materially adversely affect the rights granted to Mundipharma under this Agreement; 

(n) Intellectual Property Rights. The Allos Technology and the Allos Manufacturing Know-How and the Allos ISS Technology includes
all intellectual property rights Controlled by Allos which are reasonably necessary for the Development and Commercialization of the Product by Mundipharma in accordance with the terms of this Agreement as contemplated on the Original Effective Date
and the Effective Date; 

  
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 (o) Allos Patents and Patent Applications. (i) The Allos Patents listed on
Schedule 1 are the only patents and patent applications relating to the Product, including the use and methods of manufacture of the Product, in which Allos has an interest either alone or jointly with any Third Party, and (ii) Allos
does not have Knowledge of any Information which leads it to believe that any issued patents included in the Allos Patents are invalid or unenforceable; 
 (p) Renewal and Maintenance Fees. To Allos’ Knowledge, all material renewal and maintenance fees due as of the Original Effective Date, and as of the Effective Date, with respect to the
prosecution and maintenance of the Allos Patents have been paid; 
 (q) Access to Information. Allos has, when
requested by Mundipharma to conduct its due diligence review, allowed Mundipharma access to all material information in Allos’ possession or control (i) containing the results of all preclinical testing and clinical testing of the Product;
(ii) concerning side effects, injury, toxicity or sensitivity reaction and incidents or severity thereof with respect to the Product; and (iii) in respect of the Allos Technology and the Product; 

(r) Inventors. To Allos’ Knowledge, the inventors named in the Allos Patents (excluding the PDX Patents) are all of the true
inventors for such Allos Patents and each of such inventors has assigned, or is under a written obligation to assign, to Allos or its Affiliates all of his or her right, title and interest to such Allos Patents (excluding the PDX Patents) and the
inventions described therein; 
 (s) Employee Confidentiality Agreements. All current and former employees and paid
consultants (in the case of academic consultants, those acting outside the scope of their academic affiliation) of Allos and its Affiliates who are or have been substantively involved in the conception, design, review, evaluation, reduction to
practice, or development of Allos Technology (excluding the Allos Technology licensed to Allos under the PDX License Agreement) or the Product have executed written contracts or are otherwise obligated to protect the confidential status and value
thereof and to vest in Allos exclusive ownership of the Allos Technology (excluding the Allos Technology licensed to Allos under the PDX License Agreement) and the Product; 

(t) Third Party Confidentiality. To Allos’ Knowledge, no Third Party has any Allos Know-How or Allos Manufacturing Know-How in
its possession or control which is not subject to continuing obligations of confidentiality owed to Allos or its Affiliates (except to the extent that Section 11.1(a), (b), (c), (d) or (e) applies) for at least the duration of the
term set forth in confidentiality agreements (or other agreements containing confidentiality provisions) between Allos and such Third Party; 
 (u) Provision of Primary Agreements. Allos has, when requested by Mundipharma to conduct its due diligence review, allowed Mundipharma access to all material license agreements, service agreements,
master services agreements, clinical trial agreements, supply agreements, distribution agreements, and substantially similar agreements to which Allos is a party (each, a “Primary Agreement”), and all related amendments and project
addenda or work orders (to the extent the terms of such project addenda or work orders control the corresponding terms of a Primary Agreement), that, to Allos’ Knowledge, relate to (i) the ownership of the Allos Technology,
(ii) conducting clinical studies and regulatory activities (e.g., preparation of regulatory applications) that are necessary or useful to obtain and maintain Drug Approval of the Product, and (iii) the manufacture,
supply and distribution of Raw Materials, API and Bulk Product (as each such term is defined in the Supply Agreement). 

  
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 (v) Omitted; 

(w) Safety and Efficacy. Allos has informed Mundipharma of all adverse drug reactions known to Allos relating to the Product or its
use and Allos has not received any written communication from any Regulatory Authority raising questions concerning the safety or efficacy of the Product (including any of its ingredients); 

(x) Good Practices. To Allos’ Knowledge, GLP, GCP and GMP (as applicable) have been followed in all material respects in the
Development and manufacture of the Product; 
 (y) Allos Improvements/New Technology. 

(i) There are no “Allos Improvements” (other than the Allos Patents, Allos Know-How and Allos Manufacturing Know-How) or
“New Technology” (as such terms are defined in the PDX License Agreement) under the PDX License Agreement; and 

(ii) All Allos Manufacturing Know-How used by [***] and/or [***] for the manufacture of API (as defined in the Supply Agreement)
and/or Bulk Product is owned exclusively by Allos; 
 (z) Regulatory Matters. 

(i) Allos has provided or made available, when requested by Mundipharma to conduct its due diligence review, any and all documents
and communications in its possession from and to any Governmental Authority, or prepared by any Governmental Authority, related to the Product, that may bear on compliance with the requirements of any Governmental Authority, including any notice of
inspection, inspection report, warning letter, deficiency letter, or similar communication; 
 (ii) Neither Allos
nor any of its Affiliates has received, with respect to the Product, written communication (including any warning letter, untitled letter, or similar notices) from any Governmental Authority and, to Allos’ Knowledge, there is no action pending
or threatened (including any prosecution, injunction, seizure, civil fine, suspension or recall), in each case alleging that with respect to the Product, Allos or any of its Affiliates is not currently materially in compliance with any and all
applicable Laws implemented by such Governmental Authority. Neither Allos nor any of its Affiliates has received any written notice from any Governmental Authority claiming that the research, development, manufacture, use, offer for sale, sale, or
import of the Product is not in material compliance with all applicable Laws and permits; and 
 (iii) To
Allos’ Knowledge, none of Allos, any of its Affiliates or any of their respective officers, employees or agents has made, with respect to the Product, an untrue statement of a material fact to any Governmental Authority or failed to disclose a
material fact required to be disclosed to such Governmental Authority; and 
 (aa) New Compound. Allos is not
developing any New Compound. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 60 

 9.3 Additional Representations and Warranties of Mundipharma. Mundipharma represents
and warrants to Allos as follows, as of the Original Effective Date, and as of the Effective Date: 
 (a) Ability to
Perform. Mundipharma has the liquidity to meet and comply with its foreseeable payment obligations under this Agreement and it has sufficient resources to perform (or have performed on its behalf) all of its obligations and activities, including
all of its Development, Commercialization and diligence obligations, as applicable, under this Agreement. 
 9.4
Covenants. 
 (a) No Debarment. In the course of the Development and Commercialization of the Product, neither
Party shall utilize any employee or consultant: 
 (i) who has been debarred under Section 306(a) or 306(b)
of the FD&C Act or pursuant to the analogous Laws of any Regulatory Authority; 
 (ii) who, to such
Party’s Knowledge, has been charged with, or convicted of, any felony or misdemeanor within the ambit of 42 U.S.C. §§ 1320a-7(a), 1320a-7(b)(l)-(3), or otherwise pursuant to the analogous Laws of any Regulatory Authority, or is
proposed for exclusion, or the subject of exclusion or debarment proceedings by a Regulatory Authority, during the employee’s or consultant’s employment or contract term with such Party; and 

(iii) who is excluded, suspended or debarred from participation, or otherwise ineligible to participate, in any U.S. or non-U.S.
health care programs (or who has been convicted of a criminal offense that falls within the scope of 42 U.S.C. §1320a-7 but has not yet been excluded, debarred, suspended, or otherwise declared ineligible), or excluded, suspended or debarred by
a Regulatory Authority from participation, or otherwise ineligible to participate, in any procurement or nonprocurement programs. 
 (b) Each Party shall notify the other Party promptly, but in no event later than five (5) business days, upon becoming aware that any of its employees or consultants has been excluded,
debarred, suspended or is otherwise ineligible, or is the subject of exclusion, debarment or suspension proceedings by any Regulatory Authority. 
 (c) Conduct of Activities. Each Party shall use Reasonably Diligent Efforts to conduct Development of the Product in a manner consistent with the following: (i) in the case of Mundipharma, not
materially adversely impacting Allos’ or its Affiliates’ or Third Party partner’s Development or Commercialization efforts for the Product in the Field in the Allos Territory; and (ii) in the case of Allos, not materially
adversely impacting Mundipharma’s or its Affiliates’ or Sublicensees’ Development or Commercialization efforts for the Product in the Field in the Licensed Territory; 

(d) Compliance. Each Party and its Affiliates shall comply in all material respects with all applicable Laws in the Development and
Commercialization of the Product and the performance of its obligations under this Agreement, including where applicable the statutes, regulations and written directives of the FDA, Health Canada, the EMA and any Regulatory Authority having
jurisdiction in the Licensed Territory, the FD&C Act, the Prescription Drug Marketing Act, the Federal Health Care Programs Anti-Kickback Law, 42 U.S.C. 1320a-7b(b), the statutes, regulations and written directives of Medicare, Medicaid
and all other health care programs, as defined in 42 U.S.C. § 1320a-7b(f), and the Foreign Corrupt Practices Act of 1977, each as may be amended from time to time and each to the extent applicable; 

  
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 (e) Inventors. If and to the extent required by applicable Law, each Party shall be
responsible to reimburse the inventors named in such Party’s Patents; 
 (f) No Violation. Neither Party nor any of
its Affiliates will enter into or otherwise have any obligation to any person or entity, contractual or otherwise, that is in violation of the terms of this Agreement or that would impede the fulfillment of such Party’s obligations hereunder;

 (g) Third Party Confidentiality. Each Party shall maintain the confidentiality of the Allos Know-How, Allos
Manufacturing Know-How and the Mundipharma Know-How, and shall ensure that no Third Party has any Allos Know-How, Allos Manufacturing Know-How or Mundipharma Know-How in its possession or control which is not subject to continuing obligations of
confidentiality owed to such Party or its Affiliates pursuant to the terms of agreements containing confidentiality provisions, except to the extent that Section 11.1(a), (b), (c), (d) or (e) applies to such Allos Know-How, Allos
Manufacturing Know-How or Mundipharma Know-How; 
 (h) Performance under the PDX License Agreement. Except if a breach by
Allos of the PDX License Agreement is due to Mundipharma’s breach of this Agreement, Allos shall continue to fulfill its obligations under the PDX License Agreement and covenants that it shall not materially breach the PDX License Agreement.
Allos shall notify Mundipharma, within [***] of the following occurrences: (i) its receipt from the PDX Licensor of written notice of any material breach or potential material breach by Allos under the PDX License Agreement; or (ii) any
disputes it has with the PDX Licensor pursuant to Section 13 of the PDX License Agreement; 
 (i) Enforcement of Rights
under the PDX License Agreement. Allos shall enforce its rights under the PDX License Agreement that are relevant to Mundipharma’s rights under this Agreement; 
 (j) New Technology. Allos shall notify Mundipharma if it is offered or it acquires any “New Technology” under the PDX License Agreement; 

(k) Performance under Agreements with Current Third Party Manufacturers. Allos shall fulfill its obligations under its agreements
with its Current Third Party Manufacturers and covenants that it shall not materially breach such agreements. Allos shall notify Mundipharma within [***] of its receipt of written notice from any Current Third Party Manufacturer of any material
breach or potential material breach by Allos under its agreement with such Current Third Party Manufacturer; 
 (l) MMCO
Affiliate. Mundipharma represents and covenants that MMCO is, as of the Original Effective Date, and as of the Effective Date, and shall at all times during the Term remain, an Affiliate of Mundipharma, provided, however, that if
MMCO (or its permitted Affiliate assignee) is no longer an Affiliate of Mundipharma, MMCO (or its permitted Affiliate assignee) shall transfer any rights and obligations relating to this Agreement or the Supply Agreement to another Affiliate of
Mundipharma. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 62 

 9.5 No Other Representations or Warranties. EXCEPT AS EXPRESSLY STATED IN THIS
AGREEMENT, NO REPRESENTATIONS OR WARRANTIES WHATSOEVER, WHETHER EXPRESS OR IMPLIED, INCLUDING WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, NON-INFRINGEMENT, OR NON-MISAPPROPRIATION OF THIRD PARTY INTELLECTUAL PROPERTY RIGHTS, ARE
MADE OR GIVEN BY OR ON BEHALF OF A PARTY, AND ALL REPRESENTATIONS AND WARRANTIES, WHETHER ARISING BY OPERATION OF LAW OR OTHERWISE, ARE HEREBY EXPRESSLY EXCLUDED. 
 ARTICLE 10 
 INDEMNIFICATION 

10.1 Indemnification by Allos. Allos shall, at its sole expense, defend, indemnify, and hold Mundipharma and its Affiliates
and their respective officers, directors, employees, and agents (the “Mundipharma Indemnitees”) harmless from and against any and all Third Party claims, suits, proceedings, damages, losses, liabilities, costs,
expenses (including court costs and reasonable attorneys’ fees and expenses) and recoveries (collectively, “Claims”) to the extent that such Claims arise out of, are based on, or result from (a) Development
of the Product by or on behalf of Allos or its Affiliates or its or their sublicensees (other than Mundipharma and its Affiliates) prior to the Original Effective Date, or after the Original Effective Date pursuant to an Incremental Study for which
Allos is the Conducting Party or pursuant to an Allos Study, or Allos’ conduct of an Existing Study, an Incremental Study or an Allos Required Study after the Effective Date, (b) Commercialization of the Product by or on behalf of Allos or
its Affiliates or its or their sublicensees (other than Mundipharma and its Affiliates), (c) the breach of any of Allos’ obligations under this Agreement, including Allos’ representations and warranties, covenants and agreements set
forth herein, or (d) the willful misconduct or negligent acts of Allos, its Affiliates, or the officers, directors, employees, or agents of Allos or its Affiliates. The foregoing indemnity obligation shall not apply (i) to the extent that
(x) the Mundipharma Indemnitees fail to comply with the indemnification procedures set forth in Section 10.4 and Allos’ defense of the relevant Claims is prejudiced by such failure or (y) such Claims arise out of or result from
the gross negligence or willful misconduct of Mundipharma or its Affiliates, or any related breach by Mundipharma of its representations, warranties and/or covenants hereunder; or (ii) to Claims for which Mundipharma has an obligation to
indemnify Allos pursuant to Section 10.2, as to which Claims each Party shall indemnify the other to the extent of its respective liability for such Claims. 
 10.2 Indemnification by Mundipharma. Mundipharma shall, at its sole expense, defend, indemnify, and hold Allos and its Affiliates and their respective officers, directors, employees, and
agents (the “Allos Indemnitees”) harmless from and against any and all Claims to the extent that such Claims arise out of, are based on, or result from (a) Development of the Product by or on behalf of Mundipharma
or its Affiliates or its or their Sublicensees pursuant to an Incremental Study for which Mundipharma is the Conducting Party, (b) Commercialization of the Product by or on behalf of Mundipharma or its Affiliates or its or their Sublicensees,
(c) the breach of any of Mundipharma’s obligations under this Agreement, including Mundipharma’s representations and warranties, covenants and agreements set forth herein, or (d) the willful misconduct or negligent

  
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acts of Mundipharma, its Affiliates, or the officers, directors, employees, or agents of Mundipharma or its Affiliates. The foregoing indemnity obligation shall not apply (i) to the extent
that (x) the Allos Indemnitees fail to comply with the indemnification procedures set forth in Section 10.4 and Mundipharma’s defense of the relevant Claims is prejudiced by such failure or (y) such Claims arise out of or result
from the gross negligence or willful misconduct of Allos or its Affiliates, or any related breach by Allos of its representations, warranties and/or covenants hereunder; or (ii) to Claims for which Allos has an obligation to indemnify
Mundipharma pursuant to Section 10.1, as to which Claims each Party shall indemnify the other to the extent of its respective liability for such Claims. 
 10.3 Shared Claims. Notwithstanding the foregoing, any Claims brought against either Party that directly or indirectly arise out of, are based on, or result from, the performance of any
(i) Shared Study (other than an Allos Study) in accordance with the Development Plan (including the Initial Development Plan), or (ii) an Allos-Facilitated ISS or Mundipharma-Facilitated ISS, and that (in the case of both (i) and
(ii)) are not otherwise subject to indemnity under Sections 10.1 or 10.2 (“Shared Claims”) shall be shared by the Parties; provided, that for the purposes of this Section 10.3 only, “Shared Study” means
(i) up to and including the Effective Date, any of the Existing Studies (other than an Allos Study) or Additional Studies, and (ii) after the Effective Date, Additional Studies. For clarity, any Claims brought against either Party that
directly or indirectly arise out of, are based on, or result from the performance of any Existing Study after the Effective Date shall be subject to Allos’ indemnity under Section 10.1 and any Claim that is brought after the Effective Date
but arises out of, is based on, or results from the conduct of any Existing Study prior to the Effective Date shall be a Shared Claim. Any and all damages, losses, liabilities, costs, expenses (including court costs and reasonable attorneys’
fees and expenses) and recoveries paid to a Third Party or incurred by the Parties in connection with Shared Claims (“Shared Costs”) shall be equally shared and paid for by the Parties, and each Party shall reimburse the other as
required to give effect to this Section 10.3. The Parties shall confer through the JPC how to respond to Shared Claims and how to handle Shared Claims in an efficient manner (including which Party will have the right to assume the defense of
Shared Claims). In the absence of such an agreement, each Party shall have the right to take such action with respect to Shared Claims as it deems appropriate. Notwithstanding the foregoing, the obligations set forth in this Section 10.3 shall
not apply to the extent a Shared Claim arises out of or results from the gross negligence or willful misconduct of a Party or such Party’s Affiliates, or any related breach by such Party of its representations, warranties and/or covenants
hereunder. 
 10.4 Indemnification Procedures. The Party claiming indemnity under this Article 10 (the
“Indemnified Party”) shall give written notice to the Party from whom indemnity is being sought (the “Indemnifying Party”) promptly after learning of such Claim. The Indemnified Party
shall provide the Indemnifying Party with reasonable assistance, at the Indemnifying Party’s expense, in connection with the defense of the Claim for which indemnity is being sought. The Indemnified Party may participate in and monitor such
defense with counsel of its own choosing at its sole expense; provided, however, the Indemnifying Party shall have the right to assume and conduct the defense of the Claim with counsel of its choice. The Indemnifying Party shall not
settle any Claim without the prior written consent of the Indemnified Party, not to be unreasonably withheld, unless the settlement involves only the payment of money. So long as the Indemnifying Party is actively defending the Claim in good faith,
the Indemnified Party shall not settle or compromise any such Claim without the prior written consent of the Indemnifying Party. If the Indemnifying Party does not assume and conduct the defense of the Claim as provided above, (a) the
Indemnified Party may defend against, consent to the entry of any judgment, or enter into any 

  
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settlement with respect to such Claim in any manner the Indemnified Party may deem reasonably appropriate (and the Indemnified Party need not consult with, or obtain any consent from, the
Indemnifying Party in connection therewith), and (b) the Indemnifying Party shall remain responsible to indemnify the Indemnified Party as provided in this Article 10. 
 10.5 Limitation of Liability. NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, PUNITIVE, OR INDIRECT DAMAGES ARISING FROM OR RELATING TO ANY BREACH OF
THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. NOTWITHSTANDING THE FOREGOING, NOTHING IN THIS SECTION 10.5 IS INTENDED TO OR SHALL LIMIT OR RESTRICT THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF ANY PARTY UNDER SECTION
10.1 OR 10.2, OR DAMAGES AVAILABLE FOR A PARTY’S BREACH OF CONFIDENTIALITY OBLIGATIONS IN ARTICLE 11. 
 10.6
Insurance. Each Party shall procure and maintain insurance, including product liability insurance, or shall self-insure, in each case in a manner adequate to cover its obligations hereunder and consistent with normal business practices of
prudent companies similarly situated at all times during which any Product is being clinically tested or commercially distributed or sold by such Party. Each Party shall procure insurance or self-insure at its own expense, except for clinical trial
insurance specifically obtained for any Shared Study, the costs of which shall be shared as mutually agreed by the Parties. It is understood that such insurance shall not be construed to create a limit of either Party’s liability with respect
to its indemnification obligations under this Article 10. Each Party shall provide the other Party with written evidence of such insurance or self-insurance upon request. Each Party shall provide the other Party with written notice at least thirty
(30) days prior to the cancellation, non-renewal or material change in such insurance. 
 ARTICLE 11 
 CONFIDENTIALITY 

11.1 Confidentiality. Each Party agrees that, during the Term and for a period of five (5) years thereafter, it and its
Affiliates shall keep confidential and shall not publish or otherwise disclose and shall not use for any purpose other than as provided for in this Agreement or the Supply Agreement (which includes the exercise of any rights or the performance of
any obligations hereunder or thereunder) any Confidential Information furnished to it or its Affiliate by the other Party or its Affiliate pursuant to this Agreement or the Supply Agreement, except to the extent expressly authorized by this
Agreement or the Supply Agreement or as otherwise agreed to in writing by the Parties. The foregoing confidentiality and non-use obligations shall not apply to any portion of the other Party’s Confidential Information that the receiving Party
can demonstrate by competent written proof: 
 (a) was already known to the receiving Party or its Affiliate, other than
under an obligation of confidentiality, at the time of disclosure by the other Party or its Affiliate; 
 (b) was
generally available to the public or otherwise part of the public domain at the time of its disclosure to the receiving Party or its Affiliate; 

  
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 (c) became generally available to the public or otherwise part of the public domain
after its disclosure and other than through any act or omission of the receiving Party or its Affiliate in breach of this Agreement; 
 (d) was disclosed to the receiving Party or its Affiliate by a Third Party who had a legal right to make such disclosure and who did not obtain such information directly or indirectly from the
other Party or its Affiliate; or 
 (e) was independently discovered or developed by the receiving Party or its Affiliate
without access to or aid, application or use of the other Party’s Confidential Information, as evidenced by a contemporaneous writing. 
 11.2 Authorized Disclosure. Notwithstanding the obligations set forth in Section 11.1, a Party or its Affiliate may disclose the other Party’s Confidential Information and the
terms of this Agreement to the extent: 
 (a) such disclosure is reasonably necessary (i) for the filing or
prosecuting of Patent rights as contemplated by this Agreement or the Supply Agreement; (ii) to comply with the requirements of Regulatory Authorities with respect to obtaining and maintaining Regulatory Approval of the Product; or
(iii) for prosecuting or defending litigation as contemplated by this Agreement or the Supply Agreement; 
 (b) such
disclosure is reasonably necessary to its officers, directors, employees, agents, consultants, contractors, licensees, sublicensees, attorneys, accountants, lenders, insurers or licensors on a need-to-know basis for the sole purpose of performing
its obligations or exercising its rights under this Agreement or the Supply Agreement; provided that in each case, the disclosees are bound by obligations of confidentiality and non-use no less stringent than those contained in this Agreement;

 (c) such disclosure is reasonably necessary to any bona fide potential or actual investor, acquiror, merger partner, or
other financial or commercial partner for the sole purpose of evaluating an actual or potential investment, acquisition or other business relationship; provided that in each case, the disclosees are bound by written obligations of confidentiality
and non-use having a minimum term of five (5) years; or 
 (d) such disclosure is reasonably necessary to comply with
applicable Laws, including regulations promulgated by applicable security exchanges, court order, administrative subpoena or other order. 

Notwithstanding the foregoing, in the event a Party or its Affiliate is required to make a disclosure of the other Party’s Confidential Information
pursuant to Section 11.2(a) or 11.2(d), such Party shall promptly notify the other Party of such required disclosure and, upon the other Party’s request, such Party and its Affiliates shall use reasonable efforts to obtain, or to assist
the other Party in obtaining, a protective order preventing or limiting the required disclosure. 
 11.3 Technical
Publication. All publications, and other forms of public disclosure such as abstracts and presentations, of results of studies carried out under this Agreement or otherwise relating to the Product (each of the foregoing, a
“Publication”) shall comply with the strategy established by the JPC pursuant to Section 3.1(a)(i). Neither Party nor their Affiliates may submit 

  
 66 

 
for publication, publish or present a Publication without the opportunity for prior review by the other Party, except to the extent required by applicable Laws. A Party seeking, or whose
Affiliate is seeking, to submit, publish or present a Publication shall provide the other Party the opportunity to review and comment on the proposed Publication at least fifteen (15) days prior to its intended submission for publication or
presentation. The other Party shall provide the Party seeking, or whose Affiliate is seeking, to publish or present with its comments in writing, if any, within ten (10) days after receipt of such proposed Publication. The Party seeking, or
whose Affiliate is seeking, to publish or present shall consider in good faith any comments thereto provided by the other Party and shall comply with the other Party’s request to remove any and all of such other Party’s Confidential
Information from the proposed Publication; provided, however, that Information arising from a Shared Study shall not be considered the other Party’s Confidential Information for purposes of this Section 11.3. In addition, the
Party seeking, or whose Affiliate is seeking, to publish or present shall delay the submission for a period of up to thirty (30) days in the event that the other Party can demonstrate reasonable need for such delay in order to prepare and file
a patent application for which it has prosecution control pursuant to this Agreement. If the other Party fails to provide its comments to the Party seeking, or whose Affiliate is seeking, to publish or present within such ten (10)-day period, such
other Party shall be deemed not to have any comments, and the Party seeking, or whose Affiliate is seeking, to publish or present shall be free to submit for publication or present in accordance with this Section 11.3 after the fifteen (15)-day
period has elapsed. The Party seeking, or whose Affiliate is seeking, to publish or present shall provide the other Party a copy of the manuscript, abstract or presentation at the time of the submission or presentation, as applicable. Each Party
agrees to acknowledge the contributions of the other Party and its Affiliates and their employees in all publications, as scientifically appropriate. 
 11.4 Publicity; Terms of Agreement. 
 (a) The Parties agree
that the material terms of this Agreement are the Confidential Information of both Parties, subject to the special authorized disclosure provisions set forth in this Section 11.4. 

(b) Omitted. 
 (c) If either Party or its Affiliate desires to make a public announcement concerning the material terms of this Agreement, or any clinical or regulatory announcements, such Party shall give
reasonable prior advance notice of the proposed text of such announcement to the other Party for its prior review and approval (except as otherwise provided herein), such approval not to be unreasonably withheld. A Party commenting on such a
proposed announcement shall provide its comments, if any, within five (5) business days after receiving the announcement for review, or such shorter period as may be reasonably required in order for the proposing Party to comply with any
applicable deadline for making such announcement (as such deadline is communicated by the proposing Party to the commenting Party). In addition, where required by applicable Laws, including regulations promulgated by applicable security exchanges,
such Party or its Affiliate shall have the right to make a press release announcing the achievement of each milestone under this Agreement as it is achieved, the achievements of Regulatory Approvals in the Licensed Territory as they occur, or any
other material event with respect to this Agreement or the Parties’ performance thereof, subject only to the review procedure set forth in the preceding sentence; provided that the review period shall be reduced to two (2) business days
(or such shorter period as may be reasonably required in order for the proposing Party to comply with any applicable deadline for making such press release, as such deadline is communicated by the proposing Party to the commenting Party) if

  
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the deadline for making such disclosure is five (5) or fewer business days after such achievement or event. In relation to the other Party’s review of such an announcement, such other
Party may make specific, reasonable comments on such proposed press release within the prescribed time for commentary, but shall not withhold its consent to disclosure of the information that the relevant milestone or Regulatory Approval has been
achieved or material event has occurred. Neither Party nor their Affiliates shall be required to seek the permission of the other Party to repeat any information regarding the terms of this Agreement that has already been publicly disclosed by such
Party or its Affiliate, or by the other Party or its Affiliate, in accordance with this Section 11.4, provided such information remains accurate as of such time. 
 (d) The Parties acknowledge that either or both Parties may be obligated to file under applicable Laws a copy of this Agreement with the U.S. Securities and Exchange Commission
(“SEC”) or other Governmental Authorities. Each Party shall be entitled to make such a required filing, provided that it requests confidential treatment of the commercial terms and sensitive technical terms hereof and thereof to the
extent such confidential treatment is reasonably available to such Party. In the event of any such filing, each Party will provide the other Party with a copy of this Agreement marked to show provisions for which such Party intends to seek
confidential treatment and shall reasonably consider and incorporate the other Party’s comments thereon to the extent consistent with the legal requirements, with respect to the filing Party, governing disclosure of material agreements and
material information that must be publicly filed. 
 11.5 Prior Confidentiality Agreements. The First
Confidentiality Agreement and the Second Confidentiality Agreement remain in full force and effect and are not superseded by this Agreement. All Information disclosed by a Party or its Affiliate to the other Party or its Affiliate pursuant to the
First Confidentiality Agreement or the Second Confidentiality Agreement shall be deemed to be such Party’s Confidential Information disclosed hereunder and the other Party and its Affiliates and disclosees shall have the confidentiality,
non-use and non-disclosure obligations set forth in this Article 11. In the event that any such obligations conflict with the obligations set forth in the First Confidentiality Agreement or the Second Confidentiality Agreement, then the other Party
and its Affiliates and disclosees shall comply with the obligations set forth in this Article 11. 
 11.6 Return of
Confidential Information. Except as otherwise set forth in this Agreement, upon termination of this Agreement, the receiving Party will promptly return all of the disclosing Party’s Confidential Information, including all
reproductions and copies thereof in any medium, except that the receiving Party may retain one copy for its legal files. 

11.7 Unauthorized Use. If either Party becomes aware or has Knowledge of any unauthorized use or disclosure of the other
Party’s Confidential Information, it will promptly notify the other Party of such unauthorized use or disclosure. 
 11.8
Exclusive Property. All Confidential Information is the sole and exclusive property of the disclosing Party and the permitted use thereof by the receiving Party for purposes of its performance hereunder will not be deemed a license or
other right of the receiving Party to use any such Confidential Information for any other purpose. 

  
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 ARTICLE 12 
 TERM AND TERMINATION 
 12.1 Term. This Agreement shall become
effective on the Effective Date and, unless earlier terminated pursuant to this Article 12, shall remain in effect on a country-by-country basis until the expiration of the Royalty Term for the Product in such country (the “Term”).
Upon the expiration of the Royalty Term for a Product in a particular country, the licenses granted by Allos to Mundipharma under Sections 2.1(a) and 2.1(b) in such country shall become fully-paid and royalty free and, except for the sublicenses
granted thereunder to the Allos Technology licensed to Allos under the PDX License Agreement, such licenses shall remain exclusive. Upon the expiration of the Royalty Term for a Product in a particular country pursuant to Section 7.4(b)(i) or
Section 7.4(b)(iii), the sublicenses granted under Sections 2.1(a) and 2.1(b) to the Allos Technology licensed to Allos under the PDX License Agreement in such country shall become non-exclusive. 

12.2 Termination for Breach. Each Party (the “Non-Breaching Party”) shall have the right to
terminate this Agreement in its entirety or on a country-by-country basis immediately upon written notice to the other Party (the “Breaching Party”) if the Breaching Party materially breaches its obligations under this
Agreement and, after receiving written notice identifying such material breach in reasonable detail (a “Default Notice”), fails to cure such material breach within [***] after delivery of the Default Notice (or within
[***] after delivery of the Default Notice in the event such material breach is solely based on the Breaching Party’s failure to pay any amounts due hereunder). For the avoidance of doubt, in addition to any other failure to pay any amounts due
hereunder, failure by either Party to pay any portion of its Joint Development Costs under this Agreement shall constitute a material breach of such non-paying Party’s obligations under this Agreement. 

12.3 Termination for Patent Challenge. Mundipharma will provide written notice to Allos at least [***] prior to Mundipharma
or its Affiliates or Sublicensees (individually or in association with any other person or entity) bringing an action to challenge the validity, enforceability or scope of any Allos Patents or Joint Patents anywhere in the world. In the event that
Mundipharma or its Affiliates or Sublicensees (individually or in association with any other person or entity) brings an action to challenge the validity, enforceability or scope of any Allos Patents or Joint Patents anywhere in the world, Allos
shall have the right to terminate this Agreement in its entirety immediately upon written notice to Mundipharma. 
 12.4
Unilateral Termination by Mundipharma. 
 (a) Termination Upon Written Notice. Notwithstanding any other
provision of this Agreement, Mundipharma may terminate this Agreement in its entirety upon ninety (90) days prior written notice to Allos at any time. 
 (b) Termination by Regulatory Authority. Should any serious and unexpected events or issues occur with respect to the safety of any Product as a result of which (i) Regulatory Approval for
such Product is terminated or suspended in one or more regulatory jurisdictions in the Licensed Territory, or (ii) a Regulatory Authority directs or requests discontinuance of development, use or sale of such Product in one or more countries in
the Licensed Territory, then Mundipharma’s 

  
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obligations under this Agreement with respect to such Product will be suspended in such regulatory jurisdiction(s) and/or country(ies) (as applicable) until such serious safety event is resolved
and Regulatory Approval for such Product is no longer terminated or suspended or the Regulatory Authority has given approval again to distribute or sell such Product (as applicable) in such regulatory jurisdiction(s) and/or country(ies). Mundipharma
may, upon written notice to Allos, terminate this Agreement pursuant to this Section 12.4(b) if Mundipharma’s obligations under this Agreement are suspended pursuant to this Section 12.4(b) for a period in excess of twelve
(12) months. 
 (c) Breach or Termination of PDX License Agreement. 

(i) Within [***] of receiving written notice from the PDX Licensor that Allos is in material breach of the PDX License Agreement
(a “PDX Breach”), Allos shall provide Mundipharma with written notice of such PDX Breach. To the extent that Allos is unable or unwilling to cure the PDX Breach within the applicable cure period, and provided that Allos does not
dispute the PDX Breach within the applicable cure period, the Parties hereby agree that Mundipharma shall have the right, but not the obligation, to cure such PDX Breach (or cause such PDX Breach to be cured) on behalf of Allos. To the extent that
Allos disputes the PDX Breach, Mundipharma will not proceed to cure or cause such PDX Breach to be cured in accordance with this Section 12.4(c)(i) unless and until Allos is unsuccessful in defending against such PDX Breach. In the event
Mundipharma proceeds to cure or causes such PDX Breach to be cured on behalf of Allos in accordance with this Section 12.4(c)(i), any payments owed by Mundipharma to Allos under this Agreement shall immediately be reduced by the amount so
expended by Mundipharma to cure such PDX Breach (or cause such PDX Breach to be cured) on behalf of Allos. 
 (ii)
Notwithstanding the provisions of Section 12.4(c)(i), Mundipharma may terminate this Agreement immediately on written notice to Allos in the event that the PDX License Agreement terminates for any reason unless Mundipharma has consented in
writing to such termination. 
 (d) Omitted. 

12.4A Unilateral Termination by Allos. Notwithstanding any other provision of this Agreement, Allos shall have the right to
terminate this Agreement solely with respect to the territory of Japan immediately upon written notice to Mundipharma if (i) Mundipharma fails to achieve a Japan Milestone, and (ii) after receiving written notice identifying such failure
to meet a Japan Milestone (a “Japan Milestone Default Notice”), Mundipharma fails to thereafter meet such Japan Milestone within a revised period of time, to be agreed as follows: 

(e) If, within [***] after delivery of the Japan Milestone Default Notice, Mundipharma fails to meet a Japan Milestone, the matter
shall be submitted to the JPC for its review, and the JPC shall determine a revised timetable for Mundipharma to achieve such Japan Milestone. 

  
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 (f) If the JPC is unable to agree on a revised timetable for Mundipharma’s
achievement of such Japan Milestone within [***] after such matter is submitted to the JPC, then an Expert shall determine such revised timetable for Mundipharma’s achievement of such Japan Milestone as follows: 

(i) Upon the written request of either Party, the Parties shall promptly negotiate in good faith to appoint an appropriate Expert
who shall have such scientific, technical, regulatory and commercial experience as is necessary to resolve such dispute and who shall not be or have been during the preceding five (5) years an Affiliate, employee, consultant, officer or
director of either Party or any of their respective Affiliates. If the Parties are not able to agree upon an Expert within [***] after the receipt by a Party of the written request in the immediately preceding sentence, each Party shall select one
(1) Expert within [***] thereafter, and those two (2) Experts shall select a third Expert within [***] thereafter and such third Expert (selected by the first two Experts) shall be the designated Expert for resolution of the dispute. The
fees and costs of the Expert shall be borne [***]. 
 (ii) Within [***] after the designation of the Expert, the Parties
shall each submit to the Expert and to one another a written statement of their respective positions on the reason for Mundipharma’s failure to achieve such Japan Milestone and the appropriate revised timetable for Mundipharma’s
achievement of such Japan Milestone. Each Party shall have [***] from receipt of the other Party’s submission to submit a written response thereto, which shall include any scientific, commercial and technical information in support thereof. The
Expert shall have the right to meet with the Parties, either alone or together, as necessary to make a determination. 

(iii) No later than [***] after the designation of the Expert, the Expert shall make a determination by selecting the revised
timetable for Mundipharma’s achievement of such Japan Milestone of one of the Parties that as a whole is the most fair and reasonable to the Parties in light of the totality of the circumstances resulting in Mundipharma’s failure to
achieve such Japan Milestone (such circumstances as may include actions taken by any Regulatory Authorities in Japan as it relates to Mundipharma’s achievement of such Japan Milestone, and any correspondence, meetings and other interactions
between Mundipharma and such Regulatory Authorities in Japan (as the same shall be disclosed to the Expert and Allos together with Mundipharma’s written statement in support of its position)), and the Expert shall provide the Parties with a
written statement setting forth the basis of the determination in connection therewith. The Expert shall not have authority to render any substantive decision other than to select the position proposed by Allos or Mundipharma. The determination of
the Expert shall be final and conclusive. 
 12.5 Termination for Bankruptcy. Each Party shall have the right to terminate
this Agreement in its entirety immediately upon written notice to the other Party if the other Party (i) applies for or consents to the appointment of, or the taking of possession by, a receiver, custodian, trustee or liquidator of itself or of
all or a substantial part of its property, (ii) makes a general assignment for the benefit of its creditors, (iii) commences a voluntary case under the Bankruptcy Code, (iv) files a petition seeking to take advantage of any applicable
Laws relating to bankruptcy, insolvency, reorganization, winding-up, or composition or readjustment of debts, (v) has a proceeding or case commenced against it in any court of competent jurisdiction (which proceeding or case is not discharged
within sixty (60) days of the filing thereof), seeking (A) its liquidation, reorganization, dissolution or winding-up, or the composition or readjustment of its debts, (B) the 

  
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appointment of a trustee, receiver, custodian, liquidator or the like of all or any substantial part of its assets, or (C) similar relief under the Bankruptcy Code, or an order, judgment or
decree approving any of the foregoing is entered and continues unstayed for a period of sixty (60) days, or (vi) has an order for relief against it entered in an involuntary case under the Bankruptcy Code. 

12.6 Effect of Termination. 
 (a) Upon the early termination of this Agreement pursuant to Sections 12.2, (except as otherwise provided in Section 12.6(c)), 12.3, 12.4 (other than Section 12.4(c)(ii)), 12.4A or 12.5,
all licenses granted to Mundipharma under Section 2.1 shall terminate throughout (i) the Licensed Territory, upon the early termination of this Agreement pursuant to Sections 12.2 (except as otherwise provided in Section 12.6(c)),
12.3, 12.4 (other than Section 12.4(c)(ii)) or 12.5, or (ii) the territory of Japan, upon the early termination of this Agreement pursuant to Section 12.4A (save, in the case of both (i) and (ii), to the extent required to enable
Mundipharma to sell its inventory of Product which Allos does not purchase pursuant to Section 12.6(a)(v)) and the following shall apply (in addition to any other rights and obligations under this Agreement with respect to such termination):

 (i) Regulatory Materials; Data; Domain Names. To the extent permitted by applicable Laws, Mundipharma shall transfer
and assign to Allos: (A) all Regulatory Materials, Regulatory Approvals, and related data relating to the Product throughout the Licensed Territory, or solely with respect to the territory of Japan, as applicable, except for Incremental Studies
where Mundipharma is the Conducting Party and Allos has not exercised its Opt-In Right pursuant to Section 4.4(c)(v), and (B) all domain names registered by Mundipharma in accordance with Section 8.9(d), and, in connection with the
preceding, Mundipharma shall cooperate as reasonably requested by Allos to effect such transfer on the applicable domain name registries. 
 (ii) Mundipharma License. Mundipharma hereby grants to Allos, effective upon such termination, a non-exclusive, fully paid, royalty-free, irrevocable license (with the right to grant sublicenses
through multiple tiers), under the Mundipharma Technology, to Develop, make, have made, use, sell, offer for sale, import and otherwise Commercialize the Products throughout the Licensed Territory, or solely with respect to the territory of Japan,
as applicable. 
 (iii) Transition Assistance. Mundipharma shall provide such reasonable assistance as may be reasonably
necessary or useful for Allos to continue activities Mundipharma is then performing or having performed, including assigning or amending as appropriate, upon request of Allos, any agreements or arrangements with Third Party vendors to Develop,
distribute, sell or otherwise Commercialize the Product. To the extent that any such contract between Mundipharma and a Third Party is not assignable to Allos, Mundipharma shall reasonably cooperate with Allos to arrange to continue to provide such
services for a reasonable time after termination. 
 (iv) Omitted. 

  
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 (v) Inventories. Allos shall have the right to purchase from Mundipharma any and all
of the inventory of Product held by Mundipharma as of the date of termination at a price equal to the transfer price paid by Mundipharma to Allos for such inventory. Allos shall notify Mundipharma within [***] after the date of termination whether
Allos elects to exercise such right. Until Allos exercises such right, or if Allos does not exercise such right within such [***] period, then Mundipharma shall be entitled to continue selling such remaining inventory of Product subject to a
continuing obligation to pay royalties pursuant to Section 7.4(a) on Net Sales arising from such sales. 
 (vi)
Mundipharma Sublicense Agreements. Allos shall have the option, at its sole discretion, to (a) assume Mundipharma’s rights and obligations under any Mundipharma Sublicense Agreement, or (b) terminate the Mundipharma Sublicense
Agreement in its entirety. 
 (b) Upon the early termination of this Agreement by Mundipharma pursuant to
Section 12.4(c)(ii), Mundipharma may choose, in its sole discretion, (x) to take those actions and permit Allos to exercise those rights set forth in Section 12.6(a)(i), (iii), (v) and (vi), or (y) have any or all of the
following apply and, in the event that Mundipharma elects to have the following apply, the following shall be Mundipharma’s sole and exclusive remedy for or relating to Mundipharma’s termination of this Agreement pursuant to
Section 12.4(c)(ii): 
 (i) Transfer to Mundipharma. All of Mundipharma’s rights under Section 2.1 of this
Agreement shall continue, and Mundipharma shall require that Allos promptly takes, and Allos hereby agrees to take, such actions as Mundipharma may reasonably request, in order to transfer to Mundipharma or its Affiliates or Sublicensees, free of
charge, in respect of the Licensed Territory only, all of the rights, title and interest retained by Allos pursuant to Section 2.1(e). In the event of such an assignment, Allos will, at its expense and at Mundipharma’s request, deliver,
execute and/or deliver or cause to be delivered, all such assignments, consents, documents or further instruments of transfer or license, and take or cause to be taken all such actions as may be reasonably necessary to effectuate such transfer.
Allos will further reconvey and release to Mundipharma all rights and privileges originally granted to Allos by Mundipharma under this Agreement (including those granted under Section 8.9), including those co-exclusive rights, such that all
such rights and privileges will vest exclusively with Mundipharma. Mundipharma will, in such circumstances not be required to pay any further milestones required under Section 7.3 of this Agreement, but shall pay to Allos the royalties on all
Net Sales of Products in the Licensed Territory set forth in Section 7.4, after deducting (A) royalty payments made to the PDX Licensor (with respect to the same Net Sales) in accordance with Mundipharma’s assumption of the rights and
responsibilities of the PDX License Agreement pursuant to Section 12.6(b)(iii); and (B) [***] of Mundipharma’s costs (if any) of curing the consequences of Allos’ breach or actions that resulted in termination under
Section 12.4(c)(ii). Such other provisions hereof as are necessary to administer the calculation and payment of such royalties will also survive such termination, including any audit, payment and record retention provisions. Mundipharma will
thereafter be free to exercise its rights to all Product in the Licensed Territory, as reconveyed and released pursuant to this Section 12.6(b)(i) in the Licensed Territory as it may see fit, and Allos will not take any actions or make any
omissions to prevent Mundipharma therefrom; 

  
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 (ii) Transition Assistance. Allos shall provide such reasonable assistance, at no
cost to Mundipharma, as may be reasonably necessary or useful for Mundipharma to continue Developing the Product throughout the Licensed Territory to the extent Allos is then performing or having performed such activities, including assigning or
amending as appropriate, upon request of Mundipharma, any agreements or arrangements with Third Party vendors to Develop the Product. To the extent that any such contract between Allos and a Third Party is not assignable to Mundipharma, Allos shall
reasonably cooperate with Mundipharma to arrange to continue to provide such services for a reasonable time after termination; and 
 (iii) Assumption of PDX License Agreement. Provided that Mundipharma is not in breach of this Agreement at the time the PDX License Agreement terminates, in exercising its rights under
Section 12.6(b)(y), Mundipharma will assume all rights and responsibilities of Allos under the PDX License Agreement, including the royalties, milestones and sublicense fees provisions [***], to the extent applicable to the rights granted to
Mundipharma under this Agreement (i.e., in respect of the Licensed Territory only). 
 (c) Upon the early
termination of this Agreement by Mundipharma pursuant to Section 12.4(d), Mundipharma may choose, in its sole discretion, (x) to take those actions and permit Allos to exercise those rights set forth in Section 12.6(a)(i), (iii),
(v) and (vi), or (y) have any or all of the following apply and, in the event that Mundipharma elects to have the following apply, the following shall be Mundipharma’s sole and exclusive remedy for or relating to Mundipharma’s
termination of this Agreement pursuant to Section 12.4(d): 
 (i) Transfer to Mundipharma. All of Mundipharma’s
rights under Section 2.1 of this Agreement shall continue, and Mundipharma shall require that Allos promptly takes, and Allos hereby agrees to take, such actions as Mundipharma may reasonably request, in order to transfer to Mundipharma or its
Affiliates or Sublicensees, free of charge, in respect of the Licensed Territory only, all of the rights, title and interest retained by Allos pursuant to Section 2.1(e), excluding the rights, title and interest of Allos under the PDX License
Agreement unless, and only to the extent, the PDX Licensor consents to the assignment of such rights, title and interest (and assumption of the obligations) under the PDX License Agreement in respect of the Licensed Territory. In the event of such
an assignment, Allos will, at its expense and at Mundipharma’s request, deliver, execute and/or deliver or cause to be delivered, all such assignments, consents, documents or further instruments of transfer or license, and take or cause to be
taken all such actions as may be reasonably necessary to effectuate such transfer (excluding any transfer of the rights, title and interest of Allos under the PDX License Agreement unless, and only to the extent, the PDX Licensor consents to the
transfer of such rights, title and interest (and assumption of the obligations) under the PDX License Agreement in respect of the Licensed Territory). Allos will further reconvey and release to Mundipharma all rights and privileges originally
granted to Allos by Mundipharma under this Agreement (including those granted under Section 8.9), including those co-exclusive rights, such that all such rights and privileges will vest exclusively with Mundipharma; provided,
however, Mundipharma hereby grants to Allos, effective upon termination under Section 12.4(d), a non-exclusive, fully paid, royalty-free limited right and license under any Patent Controlled by Mundipharma that claims the Product or the API
or the manufacture or use in the Field 

  
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of the Product or the API to Develop, make, have made, use, sell, offer for sale, import and otherwise Commercialize the Products throughout the Allos Territory. Mundipharma will, in such
circumstances not be required to pay any further milestones required under Section 7.3 of this Agreement, but shall pay to Allos the royalties on all Net Sales of Products in the Licensed Territory set forth in Section 7.4, after deducting
(A) royalty payments made to the PDX Licensor (with respect to the same Net Sales) in accordance with Mundipharma’s assumption of the rights and responsibilities of the PDX License Agreement pursuant to Section 12.6(c)(iii) and
(B) [***] of Mundipharma’s costs (if any) of curing the consequences of Allos’ breach or actions that resulted in termination. Such other provisions hereof as are necessary to administer the calculation and payment of such royalties
will also survive such termination, including any audit, payment and record retention provisions. Mundipharma will thereafter be free to exercise its rights to all Product in the Licensed Territory, as reconveyed and released pursuant to this
Section 12.6(c)(i) in the Licensed Territory as it may see fit, and Allos will not take any actions or make any omissions to prevent Mundipharma therefrom; 
 (ii) Transition Assistance. Allos shall provide such reasonable assistance, at no cost to Mundipharma, as may be reasonably necessary or useful for Mundipharma to continue Developing the Product
throughout the Licensed Territory to the extent Allos is then performing or having performed such activities, including assigning or amending as appropriate, upon request of Mundipharma, any agreements or arrangements with Third Party vendors to
Develop the Product.To the extent that any such contract between Allos and a Third Party is not assignable to Mundipharma, Allos shall reasonably cooperate with Mundipharma to arrange to continue to provide such services for a reasonable time after
termination; and 
 (iii) Assumption of PDX License Agreement. Provided that Mundipharma is not in breach of this
Agreement on the effective date of termination of this Agreement pursuant to Section 12.4(d), in exercising its rights under Section 12.6(c)(y), Mundipharma will assume all rights and responsibilities of Allos under the PDX License
Agreement, including the royalties, milestones and sublicense fees provisions [***], to the extent applicable to the rights granted to Mundipharma under this Agreement (i.e., in respect of the Licensed Territory only). 

12.7 Survival. Termination or expiration of this Agreement shall not affect rights or obligations of the Parties under this
Agreement that have accrued prior to the date of termination or expiration. Notwithstanding anything to the contrary, the following provisions shall survive any expiration or termination of this Agreement: (i) Articles 1 (to the extent defined
terms are contained in the following surviving Articles and Sections), 10, 11 (other than Section 11.3) and 13 (other than Section 13.2); (ii) Sections 2.4, 4.10 (for a period of five (5) years after such expiration or
termination), 7.2, 7.4, 7.5, 7.6, 7.7, 7.8, 7.9, 7.10 (provided that the preceding Sections of Article 7 shall survive only with respect to any payment incurred or accrued prior to such expiration or termination), 8.1, 8.9(l), 9.5, 12.6, 12.7, 14.1,
14.3, 14.4, 14.7, 14.8, 14.9, 14.11 and 14.15; and (iii) solely with respect to Joint Patents, Sections 8.3, 8.4 and 8.5. 

  
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 ARTICLE 13 
 DISPUTE RESOLUTION 
 13.1 Arbitration. In the event of any disputes,
controversies or differences which may arise between the Parties (except for disputes arising from the JPC, which shall be handled pursuant to Section 13.2 and only handled pursuant to this Section 13.1 as provided in Section 13.2),
out of or in relation to or in connection with this Agreement, including any alleged failure to perform, or breach, of this Agreement, or any issue relating to the interpretation or application of this Agreement, then upon the request of either
Party, the Parties agree to meet and discuss in good faith a possible resolution thereof, which good faith efforts shall include at least one in-person meeting between the Executive Officers of each Party. If the matter is not resolved within [***]
following the request for discussions, either Party may then invoke arbitration under this Section 13.1. Any dispute, controversy or claim arising out of or relating to the validity, construction, interpretation, enforceability, breach,
performance, application or termination of this Agreement that is not resolved pursuant to Section 13.2 or by the Parties meeting in good faith to resolve such dispute, controversy or claim as outlined above, except for a dispute, claim or
controversy under Section 13.5, shall be settled by binding arbitration administered by JAMS pursuant to its Comprehensive Arbitration Rules and Procedures then in effect (the “JAMS Rules”), except as otherwise provided herein.
The arbitration will be conducted in New York, New York and the Parties consent to the personal and subject matter jurisdiction of the state and federal courts in New York, New York, for any case arising out of or otherwise related to this
arbitration, its conduct and its enforcement. Any situation not expressly covered by this Agreement shall be decided in accordance with the JAMS Rules. 
 13.2 Referred from JPC. With respect to disputes arising from matters delegated or referred to the JPC pursuant to the terms of this Agreement, either Party may, by written notice to the other
Party, have such dispute referred to each Party’s Executive Officers for attempted resolution by good faith negotiations within [***] after such notice is received. If the Executive Officers of the Parties are not able to resolve a dispute
within the [***] period described above, then the Executive Officer of Allos or Mundipharma, as the case may be, shall have the unilateral right to cast the deciding vote for the JPC as provided in Section 13.2(a) or 13.2(b). If neither Party
has the right to cast the deciding vote for the JPC pursuant to Section 13.2(a) or 13.2(b) (e.g., where Section 13.2(a) or 13.2(b) provides for exceptions to the Executive Officer’s right to make the final decision), then
either Party may submit the dispute for resolution pursuant to Section 13.1. 
 (a) Allos Decisions. The Executive
Officer of Allos shall have the right to make the final decision with respect to: (i) any decision regarding Development of the Product for the Field in the Allos Territory or an Incremental Study being conducted by Allos; (ii) any
decision regarding Commercialization of the Product in the Field in the Allos Territory; or (iii) all Development studies (clinical and pre-clinical) where Allos reasonably believes either that the studies pose a substantial and unwarranted
safety risk (a “Safety Reason”) or that such decision is substantially likely to cause a Material Impact (in accordance with Section 4.4(c)). Nothing in this Section 13.2(a) shall be construed to limit Allos’
(A) ability to carry out day-to-day decisions related to its Development activities as set forth in the Allos Required Studies Schedule, (B) compliance with applicable Laws or reporting requirements to Regulatory Authorities, or
(C) sole discretion with respect to pricing decisions with respect to the Product in the Allos Territory. 

  
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 (b) Mundipharma Decisions. The Executive Officer of Mundipharma shall have the right
to make the final decision with respect to: (i) any decision regarding Development of the Product for the Field in the Licensed Territory (except for a decision involving an Additional Study or a decision described in Section 13.2(a)(ii))
or an Incremental Study being conducted by Mundipharma, except where Allos reasonably believes either that there is a Safety Reason or that such decision is substantially likely to cause a Material Impact; or (ii) any decision regarding
Commercialization of the Product in the Field in the Licensed Territory. Nothing in this Section 13.2(b) shall be construed to limit Mundipharma’s (A) ability to carry out day-to-day decisions related to its Development activities as
set forth in the Development Plan, (B) compliance with applicable Laws or reporting requirements to Regulatory Authorities, or (C) sole discretion with respect to pricing decisions with respect to the Product in the Field in the Licensed
Territory. 
 13.3 Equitable Relief. Notwithstanding Sections 13.1 and 13.2, each Party acknowledges that its breach of
Article 11 may cause irreparable harm to the other Party, which cannot be reasonably or adequately compensated by damages in an action at law. By reason thereof, each Party agrees that the other Party shall be entitled, in addition to any other
remedies it may have under this Agreement or otherwise, to seek preliminary and permanent injunctive and other equitable relief from any state or federal court of competent jurisdiction in New York, New York to prevent or curtail any actual or
threatened breach of Article 11 that is reasonably likely to cause it irreparable harm. In addition, notwithstanding Sections 13.1 and 13.2, to the fullest extent provided by Law, either Party may bring an action in any court of competent
jurisdiction for injunctive relief (or any other provisional remedy) to protect a Party’s rights or enforce a Party’s obligations under this Agreement pending final resolution of any claims related thereto pursuant to the dispute
resolution procedure set forth in Section 13.1. 
 13.4 Governing Law. This Agreement and all disputes arising
out of or related to this Agreement or any breach hereof shall be governed by and construed under the laws of the State of New York, without giving effect to any choice of law principles that would require the application of the laws of a different
state. 
 13.5 Patent and Trademark Disputes. Notwithstanding Section 13.1, any dispute, controversy or claim
relating to the scope, validity, enforceability or infringement of any Patent or trademark rights outside the U.S. covering the manufacture, use, importation, offer for sale or sale of the Product shall be submitted to a court of competent
jurisdiction in the country in which such Patent or trademark rights were granted or arose. 
 ARTICLE 14 

MISCELLANEOUS 
 14.1 Entire Agreement; Amendment. This Agreement amends and restates in full the Original Agreement. This Agreement, including the Exhibits and Schedules hereto, together with the Amended
Development Plan, the Allos Required Studies Schedule, the Supply Agreement, the Consent, the Letter Agreement, the Second Letter Agreement, the Pharmacovigilance Agreements, as amended, and the Technical Agreement, as amended, sets forth the
complete, final and exclusive agreement and all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties hereto with respect to the subject matter hereof and supersedes, as of the Effective
Date, all prior and contemporaneous agreements and understandings between the Parties with respect to the subject matter hereof. There are no covenants, promises, agreements, 

  
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warranties, representations, conditions or understandings, either oral or written, between the Parties with respect to the subject matter of this Agreement other than as are set forth in this
Agreement, the Amended Development Plan, the Allos Required Studies Schedule, the Supply Agreement, the Pharmacovigilance Agreement and the Technical Agreement. No subsequent alteration, amendment, change or addition to this Agreement shall be
binding upon the Parties unless reduced to writing and signed by an authorized officer of each Party. 
 14.2 Force
Majeure. Both Parties shall be excused from the performance of their obligations under this Agreement to the extent that such performance is prevented by force majeure and the non-performing Party promptly provides notice of the
prevention to the other Party. Such excuse shall continue for so long as the condition constituting force majeure continues and the non-performing Party takes reasonable efforts to remove the condition. For purposes of this Agreement, force majeure
shall include conditions beyond the control of the Parties, including an act of God, war, civil commotion, terrorist act, epidemic, failure or default of public utilities or common carriers, destruction of production facilities or materials by fire,
earthquake, storm or like catastrophe, and failure of plant or machinery (provided that such failure could not have been prevented by the exercise of skill, diligence, and prudence that would be reasonably and ordinarily expected from a skilled and
experienced person engaged in the same type of undertaking under the same or similar circumstances). Notwithstanding the foregoing, a Party shall not be excused from making payments owed hereunder because of a force majeure affecting such Party. If
a force majeure persists for more than ninety (90) days, then the Parties will discuss in good faith the modification of the Parties’ obligations under this Agreement in order to mitigate the delays caused by such force majeure.

 14.3 Notices. Any notice required or permitted to be given under this Agreement shall be in writing, shall specifically
refer to this Agreement, and shall be addressed to the appropriate Party at the address specified below or such other address as may be specified by such Party in writing in accordance with this Section 14.3, and shall be deemed to have been
given for all purposes (a) when received, if hand-delivered or sent by confirmed facsimile or a reputable courier service, or (b) five (5) business days after mailing, if mailed by first class certified or registered airmail, postage
prepaid, return receipt requested. 
  

	 	If to Allos:	Allos Therapeutics, Inc. 

 11080
Circle Point Road, 
 Suite 430 
 Westminster, Colorado 80020 
 Attn: President and Secretary 

Fax: (303) 426-4731 
 With copies to (which shall not constitute notice): 
 Allos Therapeutics, Inc.

 11080 Circle Point Road, 
 Suite 430 
 Westminster, Colorado 80020 

Attn: Legal Department 
 Fax: (303) 426-4731 
 Stradling Yocca Carlson & Rauth 

660 Newport Center Dr., Suite 1600 

  
 78 

 
Newport Beach, CA 92660 
 Attn: Shivbir S. Grewal 

Fax: (949) 823-5119 
  

	 	If to Mundipharma:	Mundipharma International Corporation Limited 

 Mundipharma House, 14 Par-la-Ville Road 
 P.O. Box HM 2332, Hamilton HM JX

 Bermuda 
 Attn: Douglas Docherty, General Manager 
 Fax: (441) 292-1472 

With a copy to (which shall not constitute notice): 
 Chadbourne & Parke LLP 
 30 Rockefeller Plaza 

New York, New York 10112 
 Attn: Stuart D. Baker 
 Fax: (212) 489-7130 

14.4 No Strict Construction; Interpretation; Headings. In the event an ambiguity or a question of intent or interpretation
arises, this Agreement will be construed as if drafted jointly by the Parties and no presumption or burden of proof will arise favoring or disfavoring either Party by virtue of the authorship of any provisions of this Agreement. The language in this
Agreement is to be construed in all cases according to its fair meaning. The definitions of the terms herein apply equally to the singular and plural forms of the terms defined. Whenever the context may require, any pronoun will include the
corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” will be deemed to be followed by the phrase “without limitation.” Unless the context requires otherwise,
(i) any definition of or reference to any agreement, instrument or other document herein will be construed as referring to such agreement, instrument or other document as from time to time amended, supplemented or otherwise modified (subject to
any restrictions on such amendments, supplements or modifications set forth herein or therein), (ii) any reference to any Laws herein will be construed as referring to such Laws as from time to time enacted, repealed or amended, (iii) any
reference herein to any person will be construed to include the person’s successors and permitted assigns, (iv) the words “herein”, “hereof” and “hereunder”, and words of similar import, will be construed to
refer to this Agreement in its entirety and not to any particular provision hereof, (v) any reference herein to the words “mutually agree” or “mutual written agreement” will not impose any obligation on either Party to agree
to any terms relating thereto or to engage in discussions relating to such terms except as such Party may determine in such Party’s sole discretion, (vi) all references herein to Sections or Exhibits will be construed to refer to Sections
and Exhibits to this Agreement, (vii) the word “days” means calendar days unless otherwise specified, (viii) except as otherwise expressly provided herein all references to “$” or “dollars” refer to the lawful
money of the U.S., and (ix) the words “copy” and “copies” and words of similar import when used in this Agreement include, to the extent available, electronic copies, files or databases containing the information, files,
items, documents or materials to which such words apply. The headings of each Article and Section in this Agreement have been inserted for convenience of reference only and are not intended to limit or expand on the meaning of the language contained
in the particular Article or Section. 

  
 79 

 14.5 Assignment. Neither Party may assign or transfer this Agreement or any
rights or obligations hereunder without the prior written consent of the other Party, except that a Party may make such an assignment without the other Party’s consent to its Affiliates or to a Third Party successor to substantially all of the
business of such Party to which this Agreement relates (such Third Party, an “Acquiror”), whether in a merger, sale of stock, sale of assets or other transaction. Any successor or assignee of rights and/or obligations
permitted hereunder shall, in writing to the other Party, expressly assume performance of such rights and/or obligations. The Allos Technology, in the case of Allos as assignor or transferor, or the Mundipharma Technology, in the case of Mundipharma
as assignor or transferor, shall exclude any Patents and Information Controlled by any Acquiror (or any Affiliate thereof, excluding a Party hereto as a result of such transaction) except to the extent such Acquiror’s Information or Patents are
Controlled by Allos or Mundipharma, as applicable, or any of Allos’ or Mundipharma’s, as applicable, Affiliates, and are necessary for the Development or Commercialization of Product and utilized in respect of the Product or the API in the
Licensed Territory or the Allos Territory, as applicable. Any assignment or transfer of this Agreement must be done together with an assignment or transfer of the Supply Agreement. Any permitted assignment shall be binding on the successors of the
assigning Party. Any assignment or attempted assignment by either Party in violation of the terms of this Section 14.5 shall be null, void and of no legal effect. 
 14.6 Performance by Affiliates. Each Party may discharge any obligations and exercise any right hereunder through any of its Affiliates. Each Party hereby guarantees the performance by its
Affiliates of such Party’s obligations under this Agreement, and shall cause its Affiliates to comply with the provisions of this Agreement in connection with such performance. Any breach by a Party’s Affiliate of any of such Party’s
obligations under this Agreement shall be deemed a breach by such Party, and the other Party may proceed directly against such Party without any obligation to first proceed against such Party’s Affiliate. 

14.7 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments, and to do all such
other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement. 
 14.8
Severability. If any one or more of the provisions of this Agreement is held to be invalid or unenforceable by any court of competent jurisdiction from which no appeal can be or is taken, the provision shall be considered severed from
this Agreement and shall not serve to invalidate any remaining provisions hereof. The Parties shall make a good faith effort to replace any invalid or unenforceable provision with a valid and enforceable one such that the objectives contemplated by
the Parties when entering this Agreement may be realized. 
 14.9 No Waiver. Any delay in enforcing a Party’s
rights under this Agreement or any waiver as to a particular default or other matter shall not constitute a waiver of such Party’s rights to the future enforcement of its rights under this Agreement, except with respect to an express written
and signed waiver relating to a particular matter for a particular period of time. 
 14.10 Independent
Contractors. Each Party shall act solely as an independent contractor, and nothing in this Agreement shall be construed to give either Party the power or authority to act for, bind, or commit the other Party in any way. Nothing herein
shall be construed to create the relationship of partners, principal and agent, or joint-venture partners between the Parties. 

  
 80 

 14.11 English Language. This Agreement was prepared in the English language,
which language shall govern the interpretation of, and any dispute regarding, the terms of this Agreement. 
 14.12
Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Each Party may execute this Agreement by
facsimile transmission or in AdobeTM Portable Document Format (PDF) sent by electronic mail. In addition, facsimile or PDF signatures of authorized signatories of any Party will be deemed to be original signatures and will be valid and binding,
and delivery of a facsimile or PDF signature by any Party will constitute due execution and delivery of this Agreement. 

14.13 Non-Solicitation of Employees. During the Term, neither Party may, directly or indirectly, recruit or solicit any
employee of the other Party who became known to the other Party through contact or interactions for the purposes of negotiating or performing this Agreement, without the prior consent of the other Party. For purposes of the foregoing,
“recruit” or “solicit” shall not include: (a) circumstances where an employee of a Party initiates contact with the other Party solely on its own with regard to possible employment without being encouraged, suggested, or
otherwise induced to make such contact by the other Party; or (b) general solicitations of employment not specifically targeted at employees of a Party, including responses to general advertisements. 

14.14 Expenses. Each of the Parties will bear its own direct and indirect expenses incurred in connection with the
negotiation and preparation of this Agreement and, except as set forth in this Agreement, the performance of the obligations contemplated hereby and thereby. 
 14.15 Intellectual Property. The Parties acknowledge and agree that the licenses granted by the Parties pursuant to Sections 2.1, 2.2 and 8.9 and all other rights granted under or pursuant
to this Agreement are and shall otherwise be deemed to be, for purposes of Section 365(n) of the Bankruptcy Code (or analogous provisions of the bankruptcy laws of any Governmental Authority), licenses of rights to “intellectual
property” as defined under Section 101(35A) of the Bankruptcy Code (or analogous foreign provisions), and that this Agreement is an executory contract governed by Section 365(n) of the Bankruptcy Code (or analogous foreign provisions)
in the event that a bankruptcy proceeding is commenced involving either Party (as licensor hereunder). Mundipharma, as the licensee of such rights under Section 2.1 and Allos, as the licensee of such rights under Section 2.2, shall retain
and may fully exercise all of its rights and elections under the Bankruptcy Code. The foregoing provisions of this Section 14.15 are without prejudice to any rights the Parties may have arising under the Bankruptcy Code or other applicable
Laws. 
 14.16 Modification of Licensed Territory. As of the Effective Date, those countries in the Licensed
Territory (as defined in the Original Agreement) that are no longer part of the Licensed Territory (as defined in this Agreement) (the “Transferred Countries”) have been removed from the Licensed Territory hereunder and
transferred to the Allos Territory, and all of Mundipharma’s obligations under the Original Agreement and this Agreement shall be deemed terminated with respect to such Transferred Countries, save for (i) any unpaid obligations of
Mundipharma accrued prior to the Effective Date, (ii) any indemnification obligations of Mundipharma under Section 10.2 with respect to Claims in the Transferred Countries brought after the Effective Date but arising out of, based on, or
resulting from Mundipharma’s conduct prior to the Effective Date, and (iii) the transition assistance provisions of this Section 14.16. With respect to the Transferred Countries, Mundipharma shall, at its expense, cooperate with Allos
and/or its designee to effect a smooth and orderly transition of the regulatory responsibilities and Development activities in the Transferred 

  
 81 

 
Countries to the extent Mundipharma is then performing or having performed such activities. Mundipharma shall provide Allos copies of all Regulatory Materials filed in the Transferred Countries,
all correspondence exchanged with the Regulatory Authorities in the Transferred Countries and other information relating to the Development or Commercialization of the Product in the Transferred Countries.From and after the Effective Date, upon the
request of Allos, Mundipharma will, and will cause its Affiliates to, do, execute, acknowledge and deliver all such further acts, assurances, deeds, assignments, transfers, conveyances and other instruments and papers as may be reasonably required
or appropriate to effect a smooth and orderly transition in the on-going Development activities of the Product in the Transferred Countries. For clarity, each party’s indemnification obligations are set forth in Section 10. 

14.17 Switzerland Option. [***] the Term, Allos will have the option to remove the territory of Switzerland from the
Licensed Territory and transfer it to the Allos Territory, which option may be exercised or terminated, at any time, by Allos by sending a written notice to Mundipharma (the “Switzerland Option”). Until such time as
the Switzerland Option is exercised, Mundipharma will have the same obligations and responsibilities to conduct Development and Commercialization activities with respect to the Product in Switzerland as Mundipharma has for any other country in the
Licensed Territory under this Agreement. Set forth in the Second Letter Agreement is (i) [***], and (ii) [***]. Mundipharma agrees to update such [***] on a [***] basis. Allos will have the right to review and approve such [***] updates to
such [***], such approval not to be unreasonably withheld or delayed. Allos agrees to reimburse Mundipharma, (A) [***], and (B) [***]. Within [***] following the end of each [***] after the Effective Date, Mundipharma shall [***].

 14.18 Amendment and Restatement. This Agreement amends and restates the Original Agreement in its entirety.
Notwithstanding such amendment and restatement of the Original Agreement, each Party will retain all rights and obligations under the Original Agreement to the extent such rights and obligations have not been specifically amended by this Agreement
and have (i) accrued prior to the Effective Date, or (ii) have not yet accrued by the Effective Date, but arise out of, are based on, or result from a Party’s conduct or an event occurring prior to the Effective Date. 

[***]: CONFIDENTIAL PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 

[Remainder of this page intentionally left blank] 

  
 82 

 IN WITNESS WHEREOF, the
Parties hereto have caused this Amended and Restated License, Development and Commercialization Agreement to be executed by their duly authorized officers as of the Effective Date. 

 

									
	MUNDIPHARMA INTERNATIONAL CORPORATION LIMITED	 		 	ALLOS THERAPEUTICS, INC.
					
	By:	 	 	 		 	By:	 	 

									
	Name:	 	Douglas Docherty	 		 	Name:	 	Abraham N. Oler
	Title:	 	General Manager	 		 	Title:	 	President and Secretary

 EXHIBIT A 
 [***] 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
 A-1 

 EXHIBIT B 

LICENSED MARKS 
  

															
	 COUNTRY
	 	 REFERENCE#
	 	 FILED
	 	 APPL#
	 	 REGDT
	 	 REG#
	 	 STATUS
	 	 CLASSES

[***] 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
 B-1 

 SCHEDULE 1 

ALLOS PATENTS 
 [***]

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
 Schedule 1 - 1EX-10.2

 Exhibit 10.2 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT MARKED WITH [***] HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT, AS AMENDED. 
  

 
 Execution Version 

ALLOS THERAPEUTICS, INC. 
 and 
 MUNDIPHARMA MEDICAL COMPANY 

AMENDED AND RESTATED SUPPLY AGREEMENT 

 TABLE OF CONTENTS 

 

							
	 Section
	 	 Title
	  	 Page
	 
	 1.
	 	DEFINITIONS	  	 	1	  
	 2.
	 	TERM	  	 	10	  
	 3.
	 	MANUFACTURE AND SUPPLY	  	 	10	  
	 4.
	 	SUPPLY SHORTFALL; SUPPLY INTERRUPTION	  	 	22	  
	 5.
	 	PRICE AND PAYMENT TERMS	  	 	23	  
	 6.
	 	REGULATORY MATTERS	  	 	26	  
	 7.
	 	INSURANCE	  	 	28	  
	 8.
	 	INDEMNIFICATION	  	 	28	  
	 9.
	 	REPRESENTATIONS AND WARRANTIES; COVENANTS	  	 	29	  
	 10.
	 	TERMINATION	  	 	33	  
	 11.
	 	CONFIDENTIALITY	  	 	34	  
	 12.
	 	DISPUTE RESOLUTION	  	 	36	  
	 13.
	 	INDEPENDENT CONTRACTOR	  	 	37	  
	 14.
	 	MISCELLANEOUS	  	 	37	  

 Exhibit A – Bulk Product Specifications and API Specifications 

Exhibit B – Technical Agreement 
 Exhibit C
– Spreadsheet with Sample Calculation of Bulk Product Actual Direct Cost or Bulk Product Anticipated Direct Cost 

 AMENDED AND RESTATED SUPPLY AGREEMENT 

THIS AMENDED AND RESTATED SUPPLY AGREEMENT (this “Agreement”), dated this 29th day of May, 2013 (the “Amendment Effective Date”),
is by and between Allos Therapeutics, Inc., a Delaware corporation having a place of business at 11080 Circle Point Road, Suite 430, Westminster, Colorado 80020 (“Allos”), and Mundipharma Medical Company, a partnership organized
under the laws of Bermuda, having a place of business at 14 Par-la-Ville Road, P.O. Box HM 2332, Hamilton HM JX, Bermuda (“MMCO”). 
 RECITALS: 
 WHEREAS, Mundipharma International Corporation
Limited, a Bermuda corporation (“MICL”), and Allos have entered into a license, development and commercialization agreement dated as of May 10, 2011, and amended and restated of even date herewith, pursuant to which MICL has exclusive
rights to develop and commercialize certain pharmaceutical products (including the Product (as defined below)) in the Licensed Territory (as defined below) (the “License Agreement”); 

WHEREAS, Allos has agreed to supply MMCO with Bulk Product (as defined below) and API (as defined below), to enable the Bulk
Product to be developed and the resulting Product to be commercialized in the Licensed Territory and to enable the API to be utilized in non-clinical studies, in each case in accordance with the License Agreement; and 

WHEREAS, MMCO and Allos entered into an agreement governing the supply arrangement between them in respect of Bulk Product and
API, providing, inter alia, for forecasting, ordering, shipping and other matters, all as more fully set forth herein, dated as of May 10, 2011, which the Parties now desire to amend and restate, as set forth herein. 

NOW, THEREFORE, the Parties agree as follows: 
 1. DEFINITIONS. 
 1.1 For purposes hereof, the following terms have the
meanings set forth below: 
 “Acquiror” has the meaning set forth in Section 14.2. 

“Adulterated” has the meaning set forth in the FD&C Act. 

“Affiliate” means, with respect to either Party, any person, firm, trust, corporation, partnership or other entity or
combination thereof that directly or indirectly controls, is controlled by or is under common control with such Party; the term “control” (including, with correlative meaning, the terms “controlled by” or “under common
control with”) meaning direct or indirect ownership of fifty percent (50%) or more, including ownership by trusts with substantially the same beneficial interests, of the voting and equity rights of such person, firm, trust, corporation,
partnership or other entity or combination thereof, or the power to direct the management of such person, firm, trust, corporation, partnership or other entity or combination thereof. 

 “Agreement” means this Supply Agreement, as it may be amended or modified
from time to time. 
 “Allos” has the meaning set forth in the first paragraph of this Agreement. 

“Allos Indemnitees” has the meaning set forth in Section 8.2. 

“Allos Manufacturing Know-How” means all Information that is necessary or useful for the manufacture and quality testing
of the Bulk Product in the Field and is Controlled by Allos or its Affiliates as of the Effective Date or during the Term; provided, the use of “Affiliate” in this definition shall exclude any Third Party that becomes an Affiliate of Allos
after the Effective Date due to a Change of Control of Allos, except to the extent such Third Party’s Information is Controlled by Allos (or its Acquiror) or any of its other Affiliates and is necessary for the manufacture of, and is utilized
by or on behalf of Allos in respect of, the Bulk Product or the API in the Allos Territory or the Licensed Territory.  

“Allos Share” means sixty percent (60%). 
 “Allos Territory” means the U.S., Canada, the European Countries and Turkey and (i) any country(ies) that is/are removed from the Licensed Territory and transferred to Allos
Territory in accordance with Section 6.6(b), and (ii) Switzerland, upon the exercise by Allos of the Switzerland Option in accordance with Section 14.17 of the License Agreement. 

“Amendment Effective Date” has the meaning set forth in the preamble to this Agreement. 

“[***]” means [***], a Delaware corporation with its principal offices at [***]. 

“API” means [***]; provided, that any and all references to “API” hereunder shall mean API for use in [***],
and not API that is otherwise [***], unless the context otherwise requires or unless otherwise noted. 
 “API Actual
Direct Cost” means, with respect to API made in a particular Calendar Year, the sum of (i) [***] and (ii) [***], in each case of (i) and (ii) allocated [***], and (iii) [***]. 

“API Anticipated Direct Cost” means, with respect to API made in a particular Calendar Year, the sum of (i) [***]
and (ii) [***], in each case of (i) and (ii) allocated [***], and (iii) [***]. 
 “API
Specifications” means those specifications for API set forth in Exhibit A attached hereto as may be amended or supplemented from time to time in accordance with Sections 6.1 and 6.2. 

“API Supply Amendment” has the meaning set forth in Section 3.5(c). 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 2 

 “Audited Party” has the meaning set forth in Section 5.5(b).

 “Auditing Party” has the meaning set forth in Section 5.5(b). 

“Bankruptcy Code” means, as applicable, the U.S. Bankruptcy Code, as amended from time to time, and the rules and
regulations and guidelines promulgated thereunder or the bankruptcy laws of any Governmental Authority, as amended from time to time, and the rules and regulations and guidelines promulgated thereunder. 

“[***]” means [***] corporation with its principal offices at [***]. 

“[***] Supply Agreement” means that certain clinical and commercial supply agreement, entered into effective as of
[***], between Allos and [***]. 
 “Breaching Party” has the meaning set forth in Section 10.2.

 “Bulk Product” means the pharmaceutical product that is (i) currently being sold in the Allos Territory
as Folotyn, which product contains volumes of [***] or [***] of the API in its current formulation and at a concentration of [***], or as subsequently changed, in accordance with the terms of this Agreement, to comply with any Drug Approval in the
Licensed Territory, and (ii) currently utilized in clinical trials with [***],[***] or [***] of the API in its current formulation and at a concentration of [***], in each case delivered in unlabeled vials, in its current presentation.

 “Bulk Product Actual Direct Cost” means, for each presentation of Bulk Product for a particular Calendar
Year, the sum of (i) [***], and (ii) [***], and (iii) [***], in each case of (i)-(iii) [***], and (iv) [***]. 
 “Bulk Product Anticipated Direct Cost” means, for each presentation of Bulk Product for a particular Calendar Year, the sum of (i) [***], and (ii) [***], and (iii) [***],
in each case of (i)-(iii) allocated [***], and (iv) [***]. 
 “Bulk Product Specifications” means
those specifications for Bulk Product set forth in Exhibit A attached hereto as may be amended or supplemented from time to time in accordance with Sections 6.1 and 6.2. 

“Calendar Quarter” means each of the three month periods ending March 31st, June 30th, September 30th and December 31st. 

“Calendar Year” means the 12 month period from January 1st through December 31st. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 3 

 “Change of Control” means, with respect to either Party, (i) the sale
of all or substantially all of such Party’s assets or business relating to this Agreement; (ii) a merger, consolidation, share exchange or other similar transaction involving such Party and any Third Party which results in the holders of
the outstanding voting securities of such Party immediately prior to such merger, consolidation, share exchange or other similar transaction ceasing to hold more than fifty percent (50%) of the combined voting power of the surviving, purchasing
or continuing entity immediately after such merger, consolidation, share exchange or other similar transaction, or (iii) the acquisition by a person or entity, or group of persons or entities acting in concert, of more than fifty percent
(50%) of the outstanding voting equity securities of such Party; in all cases of clauses (i)-(iii), where such transaction is to be entered into with any person or group of persons other than the other Party or its Affiliates. 

“Claims” has the meaning set forth in Section 8.1. 

“CMC Information” means Information related to the chemistry, manufacturing and controls of the Bulk Product, as
specified by the FDA, EMA and other applicable Regulatory Authorities. 
 “Confidential Information” of a Party
means any and all Information of such Party or its Affiliates that is disclosed by such Party or its Affiliates to the other Party or its Affiliates under this Agreement, whether in oral, written, graphic, or electronic form. 

“Consent” means the consent and agreement among Allos, the PDX Licensor (as defined in the License Agreement) and MICL,
dated of the Effective Date. 
 “Contracting Party” has the meaning set forth in Section 3.12(b)(i).

 “Control” means, with respect to any material, Information, or intellectual property right, that a Party
(a) owns or (b) has a license (other than a license granted to such Party under this Agreement) to such material, Information, or intellectual property right, and in each case, has the ability to grant to the other Party access, a license
or a sublicense (as applicable) to the foregoing on the terms and conditions set forth in this Agreement without violating the terms of any then-existing agreement or other arrangement with any Third Party. 

“Default Notice” has the meaning set forth in Section 10.2. 

“Drug Approval” means an approval granted by the appropriate Regulatory Authority to market the Product in the Field in
any particular jurisdiction in the Licensed Territory. 
 “Effective Date” means May 10, 2011. 

“EMA” means the European Medicines Agency or any successor entity. 

“European Countries” means Austria, Belgium, Bulgaria, Croatia, Cyprus, the Czech Republic, Denmark, Estonia, Finland,
France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Liechtenstein, Lithuania, Luxembourg, Macedonia, Malta, Monaco, Montenegro, the Netherlands, Norway, Poland, Portugal, Romania, Serbia, Slovakia, Slovenia, Spain, Sweden and the
United Kingdom. 
 “Excess Orders” has the meaning set forth in Section 3.4(d). 

  
 4 

 “Executive Officers” means the Chief Executive Officer of Allos and the
Regional Director, Europe of Mundipharma International Limited, an Affiliate of MMCO (or their designees). 
 “FD&C
Act” means the U.S. Federal Food, Drug and Cosmetic Act, as amended. 
 “FDA” means the U.S. Food and
Drug Administration or any successor entity. 
 “[***]” means [***], a corporation [***], with its principal
offices at [***]. 
 “Field” means the diagnosis or treatment of [***]. 

“Firm Order” means a written irrevocable firm purchase order for Bulk Product or API, which order must include a
delivery schedule specifying the delivery date for the Bulk Product or API ordered and must be submitted and accepted in accordance with Sections 3.4(a), (b) and (c) or 3.5(a) and (b), respectively. 

“First Commercial Sale” means, with respect to a particular Product, the first sale to a Third Party of such Product in
a given regulatory jurisdiction in the Licensed Territory after Drug Approval has been obtained in such jurisdiction. 

“First Confidentiality Agreement” means the confidentiality agreement between Allos and MICL dated [***]. 

“GMPs” means the standards relating to the then-current Good Manufacturing Practices for fine chemicals, API,
intermediates, bulk products or finished pharmaceutical products set forth (i) in 21 U.S.C. 351(a)(2)(B), in U.S. FDA regulations at 21 C.F.R. Parts 210 and 211 and in The Rules Governing Medicinal Products in the European Community, Volume IV,
Good Manufacturing Practice for Medicinal Products, each as may be amended from time to time, (ii) in ICH Guidelines relating to the manufacture of API and finished pharmaceuticals as may be amended from time to time, or (iii) applicable
Laws promulgated by any Governmental Authority having jurisdiction over the manufacture of compounds or products or any components of either of the foregoing in the countries in which the Bulk Product or API, as applicable, will be used or sold.

 “Governmental Authority” means any multi-national, federal, state, local, municipal, provincial or other
governmental authority of any nature (including any governmental division, prefecture, subdivision, department, agency, bureau, branch, office, commission, council, court or other tribunal). 

“ICH” means the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals
for Human Use. 
 “ICH Guidelines” means the guidelines of the ICH. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 5 

 “Indemnified Party” has the meaning set forth in Section 8.3.

 “Indemnifying Party” has the meaning set forth in Section 8.3. 

“Indication” means any disease or condition that can be diagnosed or treated. 

“Information” means any data, results, technology, business or financial information or information of any type
whatsoever, in any tangible or intangible form, including know-how, trade secrets, practices, techniques, methods, processes, inventions, developments, specifications, formulations, formulae, materials or compositions of matter of any type or kind
(patentable or otherwise), software, algorithms, marketing reports, expertise, technology, test data (including pharmacological, biological, chemical, biochemical, clinical test data and data resulting from non-clinical studies), CMC information,
stability data and other study data and procedures. 
 “JAMS Rules” has the meaning set forth in
Section 12.1. 
 “Joint Manufacturing Committee” or “JMC” has the meaning set forth in
Section 3.2(a). 
 “Joint Manufacturing Costs” means all costs, including out-of-pocket costs, reasonably
incurred by or on behalf of either Party (excluding internal costs) after the Effective Date, under Sections 3.12(b)(i), 3.14, 5.2 and 6.2. 
 “Joint Product Committee” or “JPC” has the meaning set forth in the License Agreement. 
 “Knowledge” means, with respect to the Party to which such term is attributed, (i) the actual knowledge of: (a) for Allos, [***]; and (b) for MMCO, the following executives
of MMCO or its Affiliates: [***], or (ii) the knowledge that any of the foregoing individuals reasonably should have gained through operating in the ordinary course of business with a level of efforts and resources consistent with the business
practices of a similarly sized company with a similarly sized infrastructure to support and carry out its operations. 

“Laws” means all laws, statutes, rules, regulations, ordinances and other pronouncements having the effect of law of any
federal, national, multinational, state, provincial, county, city or other political subdivision, domestic or foreign. 

“License Agreement” has the meaning set forth in the recitals. 

“Licensed Territory” means all countries of the world excluding those in the Allos Territory. 

“MICL” has the meaning set forth in the recitals. 

“Misbranded” has the meaning set forth in the FD&C Act. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
 6 

 “MMCO” has the meaning set forth in the first paragraph of this Agreement.

 “MMCO Indemnitees” has the meaning set forth in Section 8.1. 

“MMCO Share” means forty percent (40%). 
 “Non-Breaching Party” has the meaning set forth in Section 10.2. 
 “Non-Governmental Authority” means any public body (including the National Institute of Clinical Excellence and the Scottish Medicines Consortium in the UK; the Institute for Quality and
Efficiency in Healthcare in Germany; the Technical Scientific Commission in Italy; the Directorate of Pharmacy and Healthcare Products in Spain; and the National Union of Health Insurance Funds and the National Authority of Health in France) or
non-Governmental Authority (including “Sick Funds” in Germany) with the authority to control, approve, recommend or otherwise determine pricing and reimbursement of pharmaceutical products, including those with authority to enter into risk
sharing schemes and/or to impose retroactive price reductions, discounts, or rebates. 
 “Packaging” means all
labels, labeling, inserts, containers, including cartons, shipping cases and other like matter used in packaging or accompanying the Bulk Product, including sample packaging. 
 “Party” means Allos or MMCO and, when used in the plural, means Allos and MMCO. 
 “Permits” has the meaning set forth in Section 9.4(c). 

“Person” means an individual, corporation, limited liability company, partnership, Regulatory Authority or other entity.

 “Pharmacovigilance Agreements” means the written pharmacovigilance agreements entered into by Allos and
MICL, dated as of [***], and [***], respectively, and as may be amended from time to time, pursuant to which the parties defined and finalized the actions that the parties shall employ with respect to the Product to protect patients and promote
their well-being. The Parties agree to amend and restate the Pharmacovigilance Agreements within [***] of the Amendment Effective Date in order to align them with the provisions of this Agreement and the License Agreement. 

“Pricing Approval” means the governmental approval, agreement, determination or decision establishing prices for the
Product that can be charged in regulatory jurisdictions where the applicable Governmental Authorities approve or determine the price of pharmaceutical products. 
 “Product” means the Bulk Product in its finished packing presentation for sale in the Licensed Territory. 

  
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 “Raw Materials” means all bulk pharmaceutical ingredients (active and
inactive) and other related items necessary or used in Allos’, [***],[***],[***] or Third Party Contractors’ manufacture and supply of the Bulk Product or API in accordance herewith. 

“Recall Procedures” means the Product and Bulk Product recall procedures set forth in the Technical Agreement.

 “Regulatory Approval” means (i) Drug Approval and all other approvals necessary for the commercial sale
of the Product in a given country or regulatory jurisdiction; (ii) Pricing Approval (but only in those countries or regulatory jurisdictions where Pricing Approval is required by applicable Law for commercial sale); and (iii) Reimbursement
Approval, but only in those countries or regulatory jurisdictions where Reimbursement Approval is required for the price paid for the Product to be reimbursed by a Governmental Authority or a Non-Governmental Authority with the authority to approve
reimbursement. 
 “Regulatory Authority” means, in a particular country or jurisdiction, any applicable
Governmental Authority or Non-Governmental Authority involved in granting Regulatory Approval in such country or jurisdiction. 

“Reimbursement Approval” means the approval, agreement, determination or decision recommending or approving the Product
for use and/or establishing the prices for the Product that can be reimbursed in regulatory jurisdictions where the applicable Governmental Authority or Non-Governmental Authority approves, determines or recommends the reimbursement or use of
pharmaceutical products. 
 “Second Confidentiality Agreement” means the confidentiality agreement between
Allos and Mundipharma Pharmaceuticals Inc. dated [***]. 
 “Shelf Life Schedule” has the meaning set forth in
Section 3.3(d). 
 “Specifications” means, collectively, the API Specifications and the Bulk Product
Specifications. 
 “Sublicensee” means a Third Party to which MICL grants a sublicense of the rights granted to
MICL under the License Agreement. 
 “Supply Interruption” has the meaning set forth in Section 4.2.

 “Technical Agreement” means the agreement entered into by the Parties as of [***], and appended hereto as
Exhibit B, as may be amended by the Parties from time to time. The Parties agree to amend and restate the Technical Agreement within [***] of the Amendment Effective Date in order to align it with the provisions of this Agreement and the
License Agreement. 
 “Term” has the meaning set forth in Section 2. 

  
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 “Testing Laboratory” means [***], or such other independent testing
facility approved in the appropriate jurisdiction in the Licensed Territory as may be agreed by the Parties through the JMC. 

“Third Party” means any entity other than Allos or MMCO or an Affiliate of either of them. 

“Third Party Contractor” has the meaning set forth in Section 3.12(b). 

“Transfer Price” means, with respect to a particular Calendar Year, the price established by Allos for Bulk Product or
API in accordance with Section 5.3(a). 
 “Year-End Actual Direct Cost” means, with respect to a
particular Calendar Year, the price established by Allos for Bulk Product or API in accordance with Section 5.3(b). 
 1.2
In the event an ambiguity or a question of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the Parties and no presumption or burden of proof will arise favoring or disfavoring either Party by virtue of the
authorship of any provisions of this Agreement. The language in this Agreement is to be construed in all cases according to its fair meaning. The definitions of the terms herein apply equally to the singular and plural forms of the terms defined.
Whenever the context may require, any pronoun will include the corresponding masculine, feminine and neuter forms. The words “include”, “includes” and “including” will be deemed to be followed by the phrase
“without limitation.” Unless the context requires otherwise, (i) any definition of or reference to any agreement, instrument or other document herein will be construed as referring to such agreement, instrument or other document as
from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein); (ii) any reference to any applicable Laws herein will be construed as
referring to such applicable Laws as from time to time enacted, repealed or amended; (iii) any reference herein to any person will be construed to include the person’s successors and permitted assigns; (iv) the words
“herein”, “hereof” and “hereunder”, and words of similar import, will be construed to refer to this Agreement in its entirety and not to any particular provision hereof; (v) any reference herein to the words
“mutually agree” or “mutual written agreement” will not impose any obligation on either Party to agree to any terms relating thereto or to engage in discussions relating to such terms except as such Party may determine in such
Party’s sole discretion; (vi) all references herein to Sections or Exhibits will be construed to refer to Sections and Exhibits to this Agreement; (vii) the word “days” means calendar days unless otherwise specified;
(viii) except as otherwise expressly provided herein all references to “€” or “euros” refer to the lawful money of most of the European Countries; and (ix) the words “copy” and “copies” and
words of similar import when used in this Agreement include, to the extent available, electronic copies, files or databases containing the information, files, items, documents or materials to which such words apply. The headings of each Article and
Section in this Agreement have been inserted for convenience of reference only and are not intended to limit or expand on the meaning of the language contained in the particular Article or Section. 

  
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 2. TERM. This Agreement will commence on the Effective Date and, unless sooner
terminated as set forth in this Agreement, will continue until the expiration or termination of the License Agreement (the “Term”). 
 3. MANUFACTURE AND SUPPLY. 
 3.1 Manufacture and Supply
Obligations. Allos or its designee will manufacture, test and supply MMCO’s orders for the Bulk Product and API, in accordance with the terms hereof. 
 3.2 Joint Manufacturing Committee. 
 (a) Formation and Role.
The Parties have established a joint manufacturing committee (the “Joint Manufacturing Committee” or “JMC”) for the coordination and oversight of certain of the Parties’ activities under this Agreement. The
role of the JMC shall be to: 
 (i) coordinate forecasting, ordering and other supply-related logistics;

 (ii) discuss supply-related issues, including shortfalls and quality issues; 

(iii) no later than six months prior to the First Commercial Sale in any country in the Licensed Territory, devise, agree
upon and begin implementing a strategy for requirements of safety supplies of necessary Raw Materials and/or other materials to be utilized in the manufacture of Bulk Product, which strategy will be reviewed on an annual basis; 

(iv) discuss supply-related issues regarding other forms of drug substance or finished product (if any) being pursued
jointly by Allos and MMCO or by MMCO independently; 
 (v) discuss and coordinate manufacturing-related
complaints, recalls and any other supply related issues; 
 (vi) review and discuss proposals to engage, qualify
and maintain Third Party Contractors; 
 (vii) discuss the content and scope of any quality audit undertaken, or
to be undertaken, by Allos as it relates to its Third Party manufacturers; 
 (viii) review and agree on
Allos’ budget amounts (including agreeing on the applicable FTE rates) for performing the technical assistance contemplated under Section 3.14; 

  
 10 

 (ix) discuss whether Allos can meet the combined MMCO and Allos requirements
for Bulk Product (including by increasing batch sizes and/or capacity or through additional sources) when (A) MMCO’s rolling good faith forecast for required quantities of Bulk Product for the Licensed Territory together with Allos’
rolling good faith forecast for required quantities of Bulk Product for the Allos Territory equals or exceeds, in the aggregate, three batches (when converted to batch quantities and based on [***] then current batch size) for a four Calendar
Quarter period, as contemplated under Section 3.3(c); or (B) MMCO’s rolling good faith forecast for required quantities of Bulk Product for the Licensed Territory together with Allos’ good faith rolling forecast for required
quantities of Bulk Product for the Allos Territory equals or exceeds, in the aggregate, two batches (when converted to batch quantities and based on [***] then current batch size) for any Calendar Quarter, as contemplated under Section 3.3(c);
and 
 (x) perform such other functions as may be appropriate to further the purposes of this Agreement, with
respect to the manufacture of the Bulk Product or API, as directed by the JPC. 
 The JMC shall have only the powers expressly
assigned to it in this Section 3.2 and elsewhere in this Agreement. The JMC shall have no power to interpret, amend, modify, or waive compliance with this Agreement. 
 (b) Members. Each Party shall initially appoint three representatives to the JMC, each of whom will be an officer or employee of such Party having sufficient seniority within the applicable Party
to make decisions arising within the scope of the JMC’s responsibilities. The JMC may change its size from time to time by mutual consent of its members and each Party may replace its representatives at any time upon written notice to the other
Party. In the event a JMC representative from either Party is unable to attend or participate in a meeting of the JMC, the Party who designated such representative may designate an appropriately qualified substitute representative for the meeting,
in its sole discretion. The JMC shall have a chairperson, who shall be elected, on an annual basis, alternatively by Allos or MMCO. The initial chairperson shall be selected by Allos. The role of the chairperson shall be to convene and preside at
all meetings of the JMC and to ensure the preparation of meeting minutes, but the chairperson shall have no additional powers or rights beyond those held by other JMC representatives. 

(c) Meetings. The JMC shall meet at least twice per Calendar Year during the Term unless the Parties mutually agree in writing to a
different frequency for such meetings. Either Party may also call a special meeting of the JMC (by videoconference or teleconference) upon at least [***] prior written notice to the other Party in the event such Party reasonably believes that a
significant matter must be addressed prior to the next regularly scheduled meeting, and such Party shall provide the JMC no later than [***] prior to the special meeting with materials reasonably adequate to enable an informed decision to be made by
its members. The JMC may meet in person, by videoconference or by teleconference. Each Party shall be responsible for its own expenses relating to such meetings. As appropriate, other employee representatives or agents of the Parties may attend JMC
meetings as non-voting observers and/or presenters. The chairperson of the JMC shall be responsible for preparing reasonably detailed written minutes of all JMC meetings that reflect, without limitation, all material decisions made

  
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at such meetings. The JMC chairperson shall send draft meeting minutes to each member of the JMC for review and approval within 10 business days after each JMC meeting. Such minutes shall be
deemed approved unless one or more members of the JMC objects to the accuracy of such minutes within 10 business days of receipt. 
 (d) Decision Making. Actions to be taken by the JMC shall be taken only following unanimous vote, with each Party having one vote representing the views of its members. If the JMC fails to reach
unanimous agreement on a matter before it for decision for a period in excess of [***] from the date first presented to the JMC in writing, then either Party may submit the dispute for resolution pursuant to Section 12.2. 

3.3 Forecasts; Excess Orders; Capacity.  
 (a) At least [***] prior to the first delivery date for Bulk Products hereunder, and at least [***] before the end of each Calendar Quarter thereafter, MMCO will provide Allos with a rolling forecast of
MMCO’s best, good faith estimate of the quantities of Bulk Product to be ordered by MMCO from Allos for the next four Calendar Quarters to meet its and its Affiliates’ and Sublicensees’ reasonably anticipated requirement for Bulk
Product, with the forecast for the first Calendar Quarter in the first forecast accounting for the remainder of the Calendar Quarter during which the first delivery takes place. 

(b) Each forecast contemplated in subsection (a) above, will include a separate section for Bulk Product for clinical use and Bulk
Product for commercial use and, within each section, will specify the quantity for each presentation (e.g., quantity of [***] or [***] volumes for commercial use and quantity of [***],[***] or [***] volumes for clinical use). Allos will include such
forecasted amount in the forecasts it submits to its Third Party manufacturer(s) of Bulk Product. 
 (c) The first Calendar
Quarter of each forecast shall be binding, shall not be greater than [***] of the amount previously forecasted for such Calendar Quarter (when it was the second Calendar Quarter in the forecast) or less than [***] of the amount previously forecasted
for such Calendar Quarter (when it was the second Calendar Quarter in the forecast), and shall constitute a binding obligation: (i) for MMCO to place orders for, in the aggregate with respect to such Calendar Quarter, quantities of Bulk Product
equal to such forecasted quantity for such first Calendar Quarter; and (ii) for Allos to accept orders for, in the aggregate with respect to such Calendar Quarter, such forecasted quantity of Bulk Product for such Calendar Quarter, provided
that if MMCO’s rolling good faith forecast for required quantities of Bulk Product for the Licensed Territory for the next [***] Calendar Quarters together with Allos’ good faith rolling forecast for required quantities of Bulk Product for
the Allos Territory for the next [***] Calendar Quarters equals or exceeds, in the aggregate, [***] batches (when converted to batch quantities and based on [***] then current batch size) or if MMCO’s rolling good faith forecast for required
quantities of Bulk Product for the Licensed Territory for any Calendar 

  
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Quarter together with Allos’ good faith rolling forecast for required quantities of Bulk Product for the Allos Territory for such Calendar Quarter equals or exceeds, in the aggregate, [***]
batches (when converted to batch quantities and based on [***] then current batch size), then the following shall apply: 
 (i) Allos shall promptly notify MMCO that the aggregated rolling forecasts for Allos’ and MMCO’s required quantities of Bulk Product for the next [***] Calendar Quarters equals or exceeds, in
the aggregate, [***] batches (when converted to batch quantities and based on [***] then current batch size) or that MMCO’s rolling good faith forecast for required quantities of Bulk Product for the Licensed Territory for any Calendar Quarter
together with Allos’ good faith rolling forecast for required quantities of Bulk Product for the Allos Territory for such Calendar Quarter equals or exceeds, in the aggregate, [***] batches (when converted to batch quantities and based on [***]
then current batch size). Within [***] of receipt of MMCO’s rolling forecast, the JMC shall meet and discuss how the Parties will continue to obtain Bulk Product for their respective territories without interruption, and Allos shall discuss
with [***] its willingness to scale up the size of its batches or to otherwise increase capacity, and the costs and time involved, in order to meet the Parties’ combined anticipated requirements for Bulk Product. The JMC shall also consider
whether an additional Third Party manufacturer of Bulk Product needs to be engaged and, if they decide an additional Third Party manufacturer should be engaged, the Parties shall proceed in accordance with Section 3.12. 

(ii) Notwithstanding the outcome of such aforementioned meeting and activities of the JMC, if [***] rejects any purchase
order for Bulk Product in respect of a Calendar Quarter placed by Allos, and such rejection is because fulfillment of such purchase order would require [***] to supply Bulk Product in excess of [***] batches for such Calendar Quarter and/or would
require [***] to supply Bulk Product in excess of [***] batches for the applicable four Calendar Quarters, Allos may reject the corresponding purchase order placed by MMCO in respect of such Calendar Quarter, provided that Allos shall: 

(A) provide to MMCO written confirmation from [***] of the rejection of Allos’ order and the quantities of Bulk
Product (if any) that [***] is willing and able to supply for such Calendar Quarter in respect of all orders for Bulk Product for MMCO and Allos; 
 (B) provide to MMCO written confirmation of the quantities of Bulk Product that Allos is able to supply to MMCO for such Calendar Quarter, from safety supplies held by Allos pursuant to
Section 3.3(d) or excess inventory of Bulk Product that was not ordered by Allos for its own supply or the supply of its licensee in the Allos Territory, in order that MMCO can submit a replacement order for the quantity that Allos has
indicated it can supply; and 

  
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 (C) cooperate with MMCO to find an additional Third Party manufacturer of
Bulk Product and if Allos does not supply pursuant to Section 3.3(c)(ii)(B) the quantity originally ordered by MMCO (when combined with MMCO’s share of any amount that [***] specified pursuant to Section 3.3(c)(ii)(A) that it was
willing and able to supply) and if Bulk Product is available from an additional Third Party Contractor jointly funded by the Parties pursuant to Section 3.12(b)(i), the quantity of Bulk Product that is supplied by such additional Third Party
Contractor shall, for the remainder of the period during which [***] is unable or unwilling to supply Bulk Product, be allocated on a Calendar Quarter by Calendar Quarter basis between MMCO (for the Licensed Territory) and Allos (for the Allos
Territory) based upon the volume ratio of units of Bulk Product ordered by Allos from [***] and such additional Third Party Contractor for such Calendar Quarter for MMCO (for the Licensed Territory) and units of Bulk Product ordered by Allos from
[***] and such additional Third Party Contractor for such Calendar Quarter for itself and its licensee in the Allos Territory. 
 (iii) If Allos rejects, in accordance with Section 3.3(c)(ii), a purchase order placed by MMCO and Allos fails to deliver to MMCO, by the delivery date specified in such purchase order for Bulk
Product, the quantities of Bulk Product set forth in such purchase order, then the Minimum Quantity obligation set forth in Section 3.4(e) shall not apply until Allos resumes delivery of Bulk Product. 

Such binding obligation may be amended only by the written agreement of both MMCO and Allos, or by MMCO at its discretion in the event of a supply
shortfall as set forth in Section 4.1, provided that MMCO will pay any fees or other penalties incurred by Allos and payable to its Third Party manufacturer in connection with such amendment to the corresponding obligation. The second Calendar
Quarter of each forecast will establish minimum and maximum quantities for such Calendar Quarter in the next forecast (when such Calendar Quarter will be the first Calendar Quarter in the forecast). MMCO’s next forecast for such Calendar
Quarter (when such Calendar Quarter will be the first Calendar Quarter in the forecast) shall not be greater than [***] of the amount previously forecasted or less than [***] of the amount previously forecasted. The forecast for the third and fourth
Calendar Quarters of each forecast shall be MMCO’s good faith estimate provided to Allos for planning purposes only, with no obligation on either Party to order or supply or to reserve manufacturing capacity or Raw Materials for, the forecasted
amount for such Calendar Quarters. Notwithstanding the foregoing, during the first four Calendar Quarters after the First Commercial Sale, forecasts will not be binding and MMCO may revise its forecasts based upon market conditions. Allos will use
commercially reasonable efforts to fulfill such forecasted orders. 
 (d) Allos or its Third Party manufacturers will maintain,
at no charge to MMCO, a safety supply of [***] units in the aggregate of Bulk Product for the countries where Regulatory Approval for the Product has been obtained. Such supply of Bulk Product shall have a shelf life as required by the Regulatory
Authorities in the country where such product is to be 

  
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supplied; provided, that the shelf life of Bulk Product shall not be required to exceed [***]. Mundipharma shall provide a schedule setting forth the Bulk Product shelf life required by
Regulatory Authorities in different countries (the “Shelf Life Schedule”) within [***] of the Amendment Effective Date, which shall be incorporated into this Agreement through a side letter agreement between the Parties. If Allos
uses any of the quantities of Bulk Product that it was maintaining pursuant to this Section 3.3(d) to accept or fill an order placed by MMCO because Allos’ Third Party manufacturer did not deliver the amount ordered by Allos by the
delivery date specified in Allos’ order, then Allos will use commercially reasonable efforts to replenish (to the extent necessary to comply with the first sentence of this Section 3.3(d)) such quantities of Bulk Product within [***].

 3.4 Bulk Product Purchase Orders; Firm Orders; Requirements. 

(a) MMCO shall provide to Allos written purchase orders, each of which shall specify (i) the quantity of Bulk Product ordered for
each presentation, which quantity shall be the same as the quantity specified in the binding forecast submitted in accordance with Section 3.3, and (ii) the requested delivery date for such order, which shall be no less than [***] after
the date of such purchase order. Each order by MMCO for Bulk Product shall be (i) from the Amendment Effective Date until the [***], for at least [***] of Bulk Product, and (ii) after the [***], for at least [***] of Bulk Product.

 (b) Allos shall include the quantities specified by MMCO pursuant to subsection (a) above, in the purchase orders Allos
submits to its Third Party manufacturers of Bulk Product. 
 (c) Allos will promptly (but in no case more than [***] after its
receipt of a purchase order placed pursuant to this Section 3.4), acknowledge in writing its receipt of such Bulk Product purchase order. Within [***] after such acknowledgment of receipt, Allos must confirm in writing either (i) its
acceptance of such Bulk Product purchase order, whereupon it shall become a Firm Order, (ii) its acceptance of such Bulk Product purchase order but specifying an alternative delivery date that is no later than [***] after the date requested by
MMCO in such Bulk Product purchase order, whereupon it shall become a Firm Order, or (iii) its rejection of such Bulk Product purchase order, provided, however, that Allos may only reject Bulk Product purchase orders that either
fail to adhere to the forecast variance agreed to under Section 3.3(c) or are rejected by [***] in accordance with, and as more fully described under, Section 3.3(c). If no such order confirmation is received by MMCO within [***] after
Allos’ receipt of such purchase order, then Allos shall have been deemed to have accepted such purchase order, whereupon it shall become a Firm Order. Any purchase orders for Bulk Product submitted by MMCO shall reference this Agreement and
shall be governed exclusively by the terms contained herein. If there is any inconsistency or conflict between the terms and conditions of this Agreement and any provisions in any Bulk Product purchase order, invoice or similar document furnished by
MMCO or Allos to the other Party, the terms and conditions of this Agreement shall control except for matters of quality, in which case the Technical Agreement shall control. 

  
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 (d) In addition to the foregoing, if MMCO, in any Calendar Quarter, submits Bulk Product
purchase orders in excess of [***] of the applicable binding forecast for the Bulk Product in such Calendar Quarter (“Excess Orders”), Allos will use commercially reasonable efforts to fill the excess portion of such Excess Orders
as promptly as practicable, but will not be in breach hereof if, notwithstanding such efforts, it will be unable to fill such excess portion. For clarity, Allos shall not have any obligation to incur any fees or other penalties to fill the excess
portion of such Excess Orders or to supply to MMCO any quantities of Bulk Product that Allos had forecasted, ordered or obtained for its own account or the account of another licensee in the Allos Territory. If Allos would incur fees to fill the
excess portion of such Excess Orders, it shall bring this to MMCO’s attention and if MMCO agrees to reimburse Allos for such fees, then Allos shall fill such excess portion unless it would otherwise not be commercially reasonable to do so.

 (e) For so long as the [***] Supply Agreement is in full force and effect, MMCO shall purchase from Allos a minimum of [***]
of the requirements of MMCO and its Affiliates and their Sublicensees for Bulk Product for each Calendar Year (the “Minimum Quantity”); provided that, in the event that there is a supply shortfall under Section 4.1(a), such
Minimum Quantity shall have no further effect and MMCO shall not be obligated to purchase any Minimum Quantity from Allos until such shortfall is cured. In the event that MMCO’s orders and purchases hereunder are less than the Minimum Quantity
in any Calendar Year, at the end of such Calendar Year, other than due to a supply shortfall under Section 4.1(a), MMCO shall have up to [***] to remedy the deficiency through the purchase of additional Bulk Product. In the event that a
deficiency still exists after such [***] period, other than due to a supply shortfall under Section 4.1(a), MMCO will pay to Allos an amount equal to the cost of Bulk Product purchased by Allos from its Third Party manufacturer to avoid the
penalty payment associated with Allos’ failure to meet its Minimum Quantity (as defined in the [***] Supply Agreement) obligations under the [***] Supply Agreement. Within [***] of the end of each Calendar Year, MMCO shall provide to Allos a
report, certified by its Chief Financial Officer, of the amount of Bulk Product and API purchased by MMCO in such Calendar Year from all sources, and the amount purchased from Allos or its designee. 

(f) All orders placed by MMCO pursuant to this Section 3.4 will be sent by MMCO to Allos via courier, e-mail or facsimile, to the
address, email address or facsimile number supplied by Allos. 
 3.5 API Purchase Orders; Firm Orders; Requirements.

 (a) If MMCO desires to purchase from Allos API to be used by MMCO or its Affiliates for non-clinical use, it will submit a
purchase order to Allos upon terms to be mutually agreed by the Parties (including delivery amounts, delivery dates and acceptance and cancellation of purchase orders), provided that the cost for such API ordered by MMCO shall be equal to
Allos’ Year-End Actual Direct Cost. Any API purchase orders submitted by MMCO shall reference this Agreement and shall be governed exclusively as between this Agreement and the applicable API purchase order by the terms contained herein. If
there is any inconsistency or 

  
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conflict between the terms and conditions of this Agreement and any provisions in any API purchase order, invoice or similar document furnished by MMCO or Allos to the other Party, the terms and
conditions of this Agreement shall control except for matters of quality, in which case the Technical Agreement shall control. 

(b) If MMCO desires to purchase from Allos API to be used by MMCO or its Affiliates or Third Party manufacturer in the manufacture of Bulk
Product for use in the Licensed Territory pursuant to its license under Section 2.1(c) of the License Agreement, then MMCO and Allos shall amend this Agreement in good faith in order to enable Allos to supply MMCO and its Affiliates and their
Sublicensees with API for such use in manufacturing Bulk Product (such amendment the “API Supply Amendment”). The API Supply Amendment shall include terms and conditions covering all aspects of such supply including forecasting,
ordering, acceptance, rejection and price for such API ordered by MMCO, which shall be equal to Allos’ Year-End Actual Direct Cost. 
 3.6 Batch Samples. As more specifically set forth in the Technical Agreement, Allos will retain or cause to be retained a sample of each batch tested for at least the shelf life of the applicable
Bulk Product plus one year, or such longer period as may be required by the Bulk Product Specifications or GMPs, provided that MMCO informs Allos in writing of any applicable retention requirement of an applicable Regulatory Authority in the
Licensed Territory that exceeds the period required by the Bulk Product Specifications and Allos will use commercially reasonable efforts to retain or cause to be retained samples for such longer period. 

3.7 Order Storage. MMCO may request that Allos store Bulk Product ordered by MMCO for up to [***] after the delivery date by
providing Allos with at least [***] written notice prior to the delivery date of such Bulk Product purchase order in accordance with Section 3.4 with no additional payment obligations. Allos will use commercially reasonable efforts to comply
with MMCO’s requests under this Section 3.7. For clarity, such compliance will not change the delivery date for such Bulk Product, the shelf life of such Bulk Product on such delivery date pursuant to Section 3.8(a), or the timing for
MMCO’s acceptance of such Bulk Product pursuant to Section 3.11 or the timing of payment for such Bulk Product pursuant to Section 5.4. 
 3.8 Delivery. 
 (a) Allos will use commercially reasonable efforts to
deliver the Bulk Product ordered by MMCO in accordance with the quantities and delivery dates specified in the applicable Firm Order. Notwithstanding the foregoing provisions of this Section 3.8(a), Bulk Product (i) in the [***]
configuration for clinical use, (ii) in the [***] configuration for clinical use, and (iii) for commercial use (whether in the [***] configuration), will each have a shelf life from the delivery date of the Bulk Product (as specified in
the Firm Order for such Bulk Product) as required by the Regulatory Authorities in the country where such Bulk Product is to be supplied, as set forth in the Shelf Life Schedule; provided, that the shelf life of such Bulk Product shall not be
required to exceed [***]. 

  
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 (b) The Bulk Product will be delivered to MMCO [***] (Incoterms 2010) at [***] facility in
[***] or at the manufacturing facility or Allos’ other supplier of Bulk Product, at Allos’ discretion, subject to the relevant local laws and regulations; provided, that the delivery terms for any Bulk Product delivered to MMCO in the U.S.
shall be agreed in writing by the Parties at the time the applicable purchase order for such Bulk Product is placed and, subject to the provisions in Section 3.4(c), will become a Firm Order only upon the parties’ agreement on such
delivery terms. The API will be delivered to MMCO [***] (Incoterms 2010) at the shipping dock of [***] storage facility in [***] or of Allos’ API supplier, at Allos’ discretion. MMCO will arrange for and be responsible for the cost of all
freight, insurance charges, taxes, import and export duties, inspection fees and other charges applicable to the transport of Bulk Product or API purchased by MMCO hereunder. Allos will include in each shipment of Bulk Product or API hereunder an
itemized packing list and all other documentation as required to be included by the Technical Agreement, and if Bulk Product or API is shipped under quarantine, the written consent thereto of one of MMCO’s Quality representatives. 

3.9 Subsequent Export. MMCO will be responsible for the export or re-export of Bulk Product or API from the country of
delivery, and will comply with all applicable Laws and regulations relating to the export or re-export of Bulk Product or API, including the prohibition against unlawful transshipments. Where Bulk Product or API are destined for export or re-export
from the country of delivery, MMCO agrees and accepts that it shall act as the exporter of record, and warrants that as the exporter of record, it will duly authorize and retain an agent who will act on its behalf, assuming all attendant
responsibilities associated with the export or re-export, including obtaining any necessary export licenses. MMCO’s responsibilities as the exporter of record include cooperating with its agent in providing a detailed description and accurate
valuation and classification of the goods on the export commercial invoice, bills of lading, and all other required documentation. MMCO further agrees to defend Allos against any civil action, civil or criminal, private or public, in connection with
the subsequent export or re-export by or on behalf of MMCO or its Affiliates or Sublicensees of such goods. 
 3.10 Bulk
Product Release. The Technical Agreement contains provisions relating to the release of Bulk Product. 
 3.11
Acceptance and Rejection. 
 (a) API. Prior to delivering API ordered by MMCO pursuant to Section 3.5,
Allos will provide MMCO with the Certificate of Analysis it received from its Third Party manufacturer with respect to such API. MMCO will notify Allos, within the longer of [***] or the period in which Allos has the right under its agreement with
such Third Party manufacturer to reject such API, if its review of such Certificate of Analysis demonstrates that such API does not conform to the API Specifications or was not manufactured in accordance with GMP or is Adulterated or Misbranded. If
MMCO provides such notice in a timely manner and Allos does not dispute in good faith MMCO’s review of such Certificate of Analysis or such dispute is resolved in MMCO’s favor pursuant to Section 3.11(c), then Allos will not deliver
such API to MMCO and will use commercially reasonable efforts to obtain or identify substitute conforming 

  
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API for delivery to MMCO in accordance with this Section 3.11 and Section 3.8(b). If MMCO does not provide such notice in a timely manner then such API shall be considered accepted upon
delivery by Allos in accordance with Section 3.8(b) and MMCO shall not have a right to reject it except with respect to a latent defect which existed at the time of delivery and was not discoverable by exercise of reasonable care and for which
[***]. 
 (b) Bulk Product. Within [***] after delivery of Bulk Product to MMCO in accordance with Section 3.8(b), if
for any reason MMCO becomes aware that such Bulk Product did not conform to the Bulk Product Specifications, master batch record or relevant Bulk Product SOPs at the time of delivery, then MMCO will have the right to reject such defective shipment
of the Bulk Product by giving written notice of rejection to Allos and specify the grounds for such rejection within such [***] period. If MMCO provides such notice within such period and Allos does not dispute in good faith such rejection or such
dispute is resolved in MMCO’s favor pursuant to Section 3.11(c), then at Allos’ option, the defective shipment of the Bulk Product will be disposed of by MMCO or will be returned to Allos, in each case at Allos’ expense, MMCO
will not be obligated to pay the invoice therefor in accordance with Section 5.4 and MMCO may, at its option, (i) require Allos to use its commercially reasonable efforts to promptly replace the shipment of the defective Bulk Product with
conforming Bulk Product as soon as reasonably practicable or (ii) inform Allos that it does not wish to receive replacement therefor, in which case the relevant Firm Order will be deemed cancelled. If MMCO does not provide such notice within
such [***] period then such Bulk Product shall be considered accepted and MMCO shall not have a right to reject it except with respect to a latent defect which existed at the time of delivery and was not reasonably discoverable at the time of
delivery and for which [***]. 
 (c) If Allos disputes MMCO’s grounds for rejecting all or part of any shipment of the Bulk
Product or API as set forth above, and such dispute is not resolved by mutual agreement of the Parties within [***] of MMCO’s notice of rejection, such dispute will be resolved by the Testing Laboratory. The final written determination of the
Testing Laboratory with respect to all or part of any shipment will be final and binding upon each Party, but only as to reasons given by MMCO in rejecting the shipment or portion thereof and will have no effect on any matter for which the Testing
Laboratory did not render a determination. The Testing Laboratory will render such determination within [***] of its appointment by the Parties. The fees and expenses of the Testing Laboratory will be paid by the Party against which the
determination is made. 
 3.12 Third Party Contractors. The Parties acknowledge that Allos currently has a supply
agreement with (i) [***], Allos’ Third Party manufacturer, for the manufacturing and supply of the Bulk Product, and (ii) [***], Allos’ Third Party manufacturer, for the manufacturing and supply of API. The Parties also
acknowledge that Allos has qualified and validated [***] to manufacture and supply API and has a master services agreement with [***]. 
 (a) The Parties further acknowledge that each of Allos’ supply agreements with [***] and [***] (i) have an initial term that will expire in [***] and (ii) contain provisions for automatic
extension for [***] additional [***] terms unless either Party gives notice of intent to terminate. Allos will consult with MMCO with respect to any extension of, and engage in good 

  
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 19 

 
faith negotiations in consultation with MMCO, to improve the current terms of its supply agreements with [***] or [***]. Allos will also provide written notice to MMCO within [***] of any
decision by Allos or any receipt of notice by [***] and/or [***] to not extend Allos’ supply agreement with [***] and/or its supply agreement with [***], respectively, in accordance with their respective terms. 

(b) If either Party wishes to engage a Third Party manufacturer (a “Third Party Contractor”) to provide Bulk Product
and/or API for its territory in addition to or in lieu of [***],[***] and [***], the proposing Party shall present to the other Party’s representatives on the JMC a proposal regarding such Third Party Contractor. The JMC shall discuss such
proposed Third Party Contractor at its next meeting, whether regularly scheduled or specially requested under Section 3.2(c), and the proposing Party shall provide, within [***] after such JMC meeting (or such longer period of time as agreed
upon in writing by the Parties), any additional information reasonably requested by the other Party’s JMC representatives prior to or during such JMC meeting. 

(i) If within [***] after the JMC meeting at which a particular proposed Third Party Contractor is discussed (or such
longer period of time as agreed upon in writing by the Parties) the other Party notifies the proposing Party in writing that the other Party wishes to obtain supply of API or Bulk Product, as applicable, from such proposed Third Party Contractor,
then the costs associated with engaging, qualifying and maintaining such Third Party Contractor to supply Bulk Product or API, as applicable, for the Allos Territory and Licensed Territory will be [***] and will be [***], provided that if a proposed
Third Party Contractor for the manufacture of Bulk Product or API is [***] or [***], then [***] shall be solely responsible for the costs associated with engaging, qualifying and maintaining such Third Party Contractor to supply Bulk Product or API.
The proposing Party (such Party, the “Contracting Party”) may then negotiate in good faith and enter into an agreement with the Third Party Contractor; provided, however, (A) that the Contracting Party will
provide the other Party with an opportunity to review and provide comments upon versions of the draft agreements with such Third Party Contractor and the other Party must consent to the final version of the contract; and (B) the Parties shall
amend this Agreement as necessary to make it consistent with the relevant terms of such new supply agreement, including providing Allos with the ability to obtain supply from MMCO with terms consistent with those in this Agreement if MMCO is the
Contracting Party. Without limiting the foregoing, the Parties shall amend this Agreement to permit Allos to reject orders placed by MMCO pursuant to this Agreement if the Third Party Contractor has the right under the new supply agreement to reject
an order placed by Allos that includes the amounts ordered by MMCO and the Third Party Contractor rejects such order. For clarity, if the other Party does not consent to the final version of the contract, then Section 3.12(b)(ii) shall apply
instead of this Section 3.12(b)(i). 
 (ii) If (A) within [***] after the JMC meeting at which a
particular proposed Third Party Contractor is discussed (or such longer period of time as agreed 

  
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 20 

 
upon in writing by the Parties) the other Party (1) has not notified the proposing Party in writing that it wishes to obtain supply of API or Bulk Product, as applicable, from the proposed
Third Party Contractor or (2) has notified the proposing Party in writing that it does not wish to obtain supply of API or Bulk Product, as applicable, from such proposed Third Party Contractor; or (B) the other Party does not consent to
the agreement with the proposed Third Party Contractor pursuant to Section 3.12(b)(i) above, then the proposing Party may engage such proposed Third Party Contractor independently in its sole discretion, at its own cost and without any further
obligation to consult with or provide agreement drafts or information to the other Party, and the other Party shall not have any right to obtain supply of Bulk Product or API, as applicable, from such Third Party Contractor. 

(c) Notwithstanding the provisions of this Section 3.12, and for the avoidance of doubt, the non-Contracting Party will have no
liability of any kind to any Third Party Contractor for any breach by the Contracting Party or failure by the Contracting Party to satisfy its obligations to such Third Party Contractor under any contract, agreement or understanding that the
Contracting Party has, may have or will have with such Third Party Contractor. 
 3.13 Records; Inspection; Quality
Audits. 
 (a) Allos will maintain true and complete books and records of its data and all data provided by Allos’ Third
Party manufacturers relating to the manufacture and supply of the Bulk Product delivered to MMCO hereunder. Upon at least [***] prior written notice, and during normal business hours, MMCO will have the right to inspect and review such books and
records to the extent in Allos’ possession (including as set forth in the attached Technical Agreement) as may be necessary to ensure Allos’ compliance with the terms and conditions set forth above. To the extent Allos’ books and
records do not contain certain data relating to the manufacture and supply of the Bulk Product delivered to MMCO hereunder and such data is in possession of Allos’ Third Party manufacturer, then upon MMCO’s reasonable request, Allos will
use commercially reasonable efforts to assist MMCO in obtaining a copy of or access to such data from such Third Party manufacturer. 
 (b) Allos will provide MMCO with copies of the reports from its quality audits of [***],[***],[***] and its Third Party Contractors’ facilities with respect to the manufacture of Bulk Product or API,
as more fully set forth in the Technical Agreement. 
 (c) Allos will allow MMCO one quality audit of Allos’ manufacturing
records per Calendar Year to be carried out by MMCO’s employees or its designees upon reasonable notice and in accordance with Section 3.13(a). 
 3.14 Technical Assistance. Allos will furnish MMCO with such technical bulletins and data relative to the Bulk Product and API as reasonably appropriate from time to time. At MMCO’s
request, Allos shall make available, to MICL or its Affiliate or its Third Party manufacturer who is a Sublicensee approved by Allos under the License Agreement, all Allos 

  
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 21 

 
Manufacturing Know-How, and shall provide such other reasonable assistance, as is required to enable such entity to manufacture API and/or Bulk Product, as applicable, and take such other
reasonably necessary actions in furtherance thereof in accordance with Section 2.1(c) of the License Agreement. If such request is: (i) the result of [***], then [***]; (ii) [***], then [***]; and (iii) [***], then [***] shall be
solely responsible for all of its costs under this Section 3.14. [***]. MMCO shall pay such invoice within [***]. 
 4.
SUPPLY SHORTFALL; SUPPLY INTERRUPTION. 
 4.1 Supply Shortfall; Bulk Product Shortfall. 

(a) A supply shortfall shall be deemed to have taken place if: (i) Allos fails to deliver to MMCO by the delivery date specified in
the Firm Order for Bulk Product the quantities of Bulk Product ordered by MMCO under such Firm Order; or (ii) MMCO rejects a shipment pursuant to Section 3.11 due to non-conformity of the Bulk Product to the Bulk Product Specifications.
Allos shall use commercially reasonable efforts to cure any such supply shortfall as soon as practicable. 
 (b) Notwithstanding
the provisions of subsection (a) above, if Allos’ Third Party manufacturer of Bulk Product is not able to supply the full quantity of Bulk Product set forth in purchase orders placed by Allos during a Calendar Quarter that includes either
(i) Bulk Product for both MMCO and Allos, (ii) Bulk Product only for Allos or (iii) Bulk Product only for MMCO, then the quantity of Bulk Product that is supplied by such Third Party manufacturer on account of such purchase orders
shall be allocated between MMCO and Allos based upon the volume ratio of units of Bulk Product ordered by each Party for the Calendar Quarter during which the shortfall occurred. 

(c) For the avoidance of doubt, this Section 4.1 will not supersede or otherwise limit Allos’ obligations to supply Bulk Product
as set forth in this Agreement. 
 4.2 Supply Interruption.  

(a) In the event that (i) Allos is unable to fully deliver ordered Bulk Product to MMCO within [***] of the specified delivery date
in the relevant Firm Order (including meeting Specifications) or (ii) a supply shortfall under Section 4.1(a) has occurred in [***] Calendar Quarters (each, a “Supply Interruption”), then the Parties will meet to discuss
possible solutions and (i) Allos will use commercially reasonable efforts to supply the undelivered Bulk Product at a future date agreed upon by the Parties (as to which a failure to deliver will be deemed to be an additional Supply
Interruption), and (ii) if available, Allos will use commercially reasonable efforts to obtain Bulk Product necessary to meet MMCO’s requirements from a different Third Party Contractor of Allos (provided such Bulk Product has not already
been ordered by Allos for its own supply or the supply of its licensee in the Allos Territory). For so long as a Supply Interruption remains uncured, MMCO will have the right, at its sole election, to purchase all of its requirements for Bulk
Product directly from any Third Party Contractor of MMCO. 

  
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 5. PRICE AND PAYMENT TERMS. 

5.1 Price. For API or Bulk Product delivered to MMCO, MMCO will pay to Allos, during the term of this Agreement, the applicable
Transfer Price for the Calendar Year in which such delivery occurs; provided, however, that within [***] after the end of each Calendar Year, the Parties will perform an accounting, in respect of each unit of Bulk Product or API sold
during such calendar year, to determine the difference between (x) the applicable Transfer Price and (y) the applicable Year-End Actual Direct Cost, in each case for such Bulk Product or API delivered to MMCO during such Calendar Year (the
“Cost Differential”). If the Cost Differential shows an overpayment by MMCO, then Allos shall refund and remit to MMCO, within [***] of the determination of the Cost Differential, an amount equal to such overpayment. If the Cost
Differential shows an underpayment by MMCO, then MMCO shall pay to Allos, within [***] of the determination of the Cost Differential, an amount equal to such underpayment. 
 5.2 Reimbursement of Joint Manufacturing Costs 
 (a) MMCO
shall be responsible for the MMCO Share of all Joint Manufacturing Costs. Within [***] after the end of each Calendar Quarter during which Allos has incurred any Joint Manufacturing Costs, Allos shall submit to MMCO a reasonably detailed invoice
setting forth the total Joint Manufacturing Costs incurred by Allos in such Calendar Quarter and invoicing MMCO for the MMCO Share of such Joint Manufacturing Costs. MMCO shall pay to Allos the amount invoiced within [***] after the receipt of such
invoice. 
 (b) Allos shall be responsible for the Allos Share of all Joint Manufacturing Costs. Within [***]
after the end of each Calendar Quarter during which MMCO has incurred any Joint Manufacturing Costs, MMCO shall submit to Allos a reasonably detailed invoice setting forth the total Joint Manufacturing Costs incurred by MMCO in such calendar quarter
and invoicing Allos for the Allos Share of such Joint Manufacturing Costs. Allos shall pay to MMCO the amount invoiced within [***] after the receipt of such invoice. 

(c) All payments made by a Party pursuant to this Section 5.2 shall be non-refundable. 

5.3 Calculation of Transfer Price and Actual Direct Cost. 
 (a) Transfer Price. For each Calendar Year during the Term, Allos will calculate a Transfer Price for API and a Transfer Price for each presentation of Bulk Product for such Calendar Year. Such
calculation shall be made by Allos based upon anticipated worldwide volumes of API or Bulk Product from Allos’ suppliers, as applicable, for such Calendar Year. Such Transfer Price shall be (i) for each presentation of Bulk Product, the
Bulk Product Anticipated Direct Cost for such presentation, plus [***] and (ii) for API, the API Anticipated 

  
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Direct Cost, plus [***], in the case of (i), as exemplified in the sample calculation shown in the spreadsheet attached as Exhibit C, which is provided for informational purposes and does
not establish any obligations or reflect any expectations with respect to the amount of any Transfer Price. Allos shall give written notice to MMCO of the Transfer Price for each Calendar Year (other than 2011) no later than [***] before the
beginning of such Calendar Year. Allos shall provide MMCO with written documentation showing the basis for such Transfer Price calculations. 
 (b) Year-End Actual Direct Cost. After the end of each Calendar Year during the Term, Allos will calculate the Year-End Actual Direct Cost for API and each presentation of Bulk Product for such
Calendar Year. Such calculation shall be made by Allos based upon actual worldwide volumes of API or Bulk Product from Allos’ suppliers, as applicable, for such Calendar Year. Such Year-End Actual Direct Cost shall be (i) for each
presentation of Bulk Product, the Bulk Product Actual Direct Cost for such presentation, plus [***] and (ii) for API, the API Actual Direct Cost, plus [***], in the case of (i), as exemplified in the sample calculation shown in the spreadsheet
attached as Exhibit C, which is provided for informational purposes and does not establish any obligations or reflect any expectations with respect to the amount of any Year-End Actual Direct Cost. Allos shall give written notice to MMCO of
the Year-End Actual Direct Cost for each Calendar Year no later than [***] after the end of such Calendar Year. Allos shall provide MMCO with written documentation showing the basis for such Year-End Actual Direct Cost calculations. In the event
that a Year-End Actual Direct Cost for such Calendar Year is not determinable because no Bulk Product or API was purchased by Allos in such year, the [***] from [***] shall apply. 

5.4 Payment. Upon delivery of the Bulk Product or API to MMCO, Allos will invoice MMCO therefor. MMCO will pay each invoice in full
within [***] after the receipt of each invoice, unless delivery is validly rejected by MMCO in accordance with this Agreement. 

5.5 Audit Request.  
 (a) Year-End Actual Direct Cost. Allos will keep complete, true and accurate books and records for the purpose of determining Year-End Actual Direct Cost for API or Bulk Product delivered to MMCO
hereunder. Allos will permit an independent certified public accountant chosen by MMCO and reasonably acceptable to Allos, which acceptance will not be unreasonably withheld, to conduct audits of such books and records related to the determination
of such Year-End Actual Direct Cost that the independent certified public accountant in its judgment considers relevant, in order to verify such Year-End Actual Direct Cost. Such books and records will be kept at the principal place of business of
Allos for at least three years following the end of the calendar month to which they pertain. Such inspections may be made no more than once each calendar year, at reasonable times and on reasonable notice, and shall not include books and records
that were previously inspected. Allos will be required to respond to the independent auditor’s data requests within [***]. If, as a result of any audit of the books and records of Allos, it is shown that there is a variance in the amount paid
by MMCO under 

  
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Section 5.1 of this Agreement after calculation and payment of the Cost Differential with respect to the period of time audited as compared to the amount that should have been paid under
Section 5.1, then (i) if such variance shows an overpayment by MMCO, then Allos will, within [***] after MMCO’s demand therefor, pay to MMCO the amount of such overpayment, together with interest on such overpaid amount at the rate of
[***] over the prime rate of interest per annum reported in The Wall Street Journal for the date such amount was due (and which interest on such overpaid amount will continue to accrue during any resolution of a dispute regarding payment hereunder),
and (ii) if such variance shows an underpayment by MMCO, then MMCO will, within [***] after Allos’ demand therefor, pay to Allos the amount of such overpayment, together with interest on such overpaid amount at the rate of [***] over the
prime rate of interest per annum reported in The Wall Street Journal for the date such amount was due (and which interest on such underpaid amount will continue to accrue during any resolution of a dispute regarding payment hereunder). Inspections
conducted under this Section 5.5(a) will be at the expense of MMCO, unless a variation or error producing an overpayment of amounts payable under Section 5.1 exceeding [***] of the amount paid for the period covered by the inspection is
established in the course of such inspection, whereupon all reasonable out-of-pocket costs and expenses relating to the inspection for such period will also be paid by Allos to MMCO. If the independent certified public accountant finds a variation
or error producing an overpayment amounts payable under Section 5.1 exceeding [***] of the amount paid for any period covered by the inspection, MMCO will have the additional right to make inspections twice per year for the next two years. The
independent certified public accountant will present both Parties with a preliminary report of its findings and provide both Parties with an opportunity to respond to any questions raised or issues identified before issuing any final reports. Such
reports shall be deemed the Confidential Information of Allos. 
 (b) Joint Manufacturing Costs. Each Party will keep
complete, true and accurate books and records for the purpose of determining Joint Manufacturing Costs incurred by such Party hereunder. Each Party will permit an independent certified public accountant chosen by the other Party (such Party, in such
case, the “Auditing Party”) and reasonably acceptable to such audited Party (such Party, in such case, the “Audited Party”), which acceptance will not be unreasonably withheld, to conduct audits of such books and
records related to the determination of such Joint Manufacturing Costs that the independent certified public accountant in its judgment considers relevant, in order to verify such Joint Manufacturing Costs. Such books and records will be kept at the
principal place of business of the Audited Party for at least three years following the end of the calendar month to which they pertain. Such inspections may be made no more than once each Calendar Year, at reasonable times and on reasonable notice,
and shall not include books and records that were previously inspected. The Audited Party will be required to respond to the independent auditor’s data requests within [***]. If, as a result of any audit of the books and records of the Audited
Party, it is shown that there is a variance in the amount paid by the Auditing Party under Section 5.2 of this Agreement with respect to the period of time audited as compared to the amount that should have been paid under Section 5.2,
then (i) if such variance shows an overpayment by the Auditing Party, then the Audited Party will, within [***] after the Auditing Party’s demand therefor, pay to the Auditing 

  
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Party the amount of such overpayment, together with interest on such overpaid amount at the rate of [***] over the prime rate of interest per annum reported in The Wall Street Journal for the
date such amount was due (and which interest on such overpaid amount will continue to accrue during any resolution of a dispute regarding payment hereunder), and (ii) if such variance shows an underpayment by the Auditing Party, then the
Auditing Party will, within [***] after the Audited Party’s demand therefor, pay to the Auditing Party the amount of such overpayment, together with interest on such overpaid amount at the rate of [***] over the prime rate of interest per annum
reported in The Wall Street Journal for the date such amount was due (and which interest on such underpaid amount will continue to accrue during any resolution of a dispute regarding payment hereunder). Inspections conducted under this
Section 5.5(b) will be at the expense of the Auditing Party, unless a variation or error producing an overpayment of amounts payable under Section 5.2 exceeding [***] of the amount paid for the period covered by the inspection is
established in the course of such inspection, whereupon all reasonable out-of-pocket costs and expenses relating to the inspection for such period will also be paid by the Audited Party to the Auditing Party. If the independent certified public
accountant finds a variation or error producing an overpayment amounts payable under Section 5.2 exceeding [***] of the amount paid for any period covered by the inspection, the Auditing Party will have the additional right to make inspections
twice per year for the next two years. The independent certified public accountant will present both Parties with a preliminary report of its findings and provide both Parties with an opportunity to respond to any questions raised or issues
identified before issuing any final reports. Such reports shall be deemed the Confidential Information of the Audited Party. 

5.6 Late Payments. If Allos does not receive payment of any sum due to it on or before the due date, simple interest shall
thereafter accrue on the sum due to Allos until the date of payment at the per annum rate of [***] over the then-current prime rate as reported in The Wall Street Journal or the maximum rate allowable by applicable Laws, whichever is lower. In
addition to other remedies available to Allos in the event that MMCO fails to make any payment within [***] of the date due hereunder, Allos may refuse to accept all future purchase orders and refuse to deliver Bulk Product or API pursuant to
pending Firm Orders until MMCO’s account is paid in full. 
 6. REGULATORY MATTERS. 

6.1 Specification Approval. The Specifications attached hereto as Exhibit A for API and Bulk Product delivered to MMCO are
the same as the specifications for API and Bulk Product procured by Allos as of the Effective Date for its own use. Changes made to such Specifications in accordance with this Section 6.1 or Section 6.2 shall retain such consistency with
the then-current specifications for API and Bulk Product procured by Allos at such time for its own use, except to the extent any changes are required by Regulatory Authorities in the Licensed Territory. Allos agrees to make no changes to the API
Specifications or the Bulk Product Specifications without following the procedures set forth in this Section 6.1 or Section 6.2. Allos will notify MMCO in writing at least [***] prior to filing any planned changes in the

  
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manufacturing process that are reportable to a Regulatory Authority or any planned changes in Specifications. MMCO will have the right to review and approve or reject such changes; provided,
however, that MMCO will not have the right to reject any such changes which are mandated by applicable Laws or changes thereto. If Allos decides to implement a change to the manufacturing process for API or Bulk Product and such change is not
required to be reported to a Regulatory Authority and does not change the applicable Specifications, then Allos shall notify MMCO in writing of such change promptly after Allos’ decision to implement such change. For clarity, MMCO will not have
the right to approve or reject such change. 
 6.2 Required Specification Changes. Allos will maintain a system
(consistent with standard industry practice) to control and implement changes to API Specifications and Bulk Product Specifications, manufacturing processes and qualification procedures, in accordance with GMPs and other applicable Laws in the
United States, the European Countries or under ICH Guidelines. Each Party will provide written notice in a timely manner to the other Party of any other applicable Laws in their respective territories that require any such changes. Any costs
associated with changes to the Specifications required by Regulatory Authorities in the Licensed Territory that are not also required in the U.S. or Canada will be [***]. Any costs associated with changes to the API Specifications and Bulk Product
Specifications procured by Allos for its own use required by Regulatory Authorities in the U.S. or Canada will be [***] unless such changes are also required by Regulatory Authorities in the Licensed Territory, in which case [***]. 

6.3 Communications with Regulatory Authorities. The Technical Agreement contains provisions relating to reporting and filing
obligations to Regulatory Authorities with respect to manufacture of Bulk Product. As more fully set forth in the Technical Agreement, both Parties will promptly provide to each other copies of correspondence to and from any Regulatory Authority
relating to or impacting the manufacture of any Bulk Product, including correspondence to, from or among [***], any Third Party Contractors and any Regulatory Authority with respect to the Bulk Product. 

6.4 Complaints. The Technical Agreement contains provisions relating to complaints. 

6.5 Adverse Drug Experience Information. The Pharmacovigilance Agreements contain provisions relating to adverse drug experiences.

 6.6 Good Manufacturing Practices. The Technical Agreement contains provisions relating to GMPs. If Allos’ failure
to comply with applicable Laws causes a Supply Interruption, Section 4 of this Agreement will apply. 
 6.7 Bulk Product
or Product Recalls or Seizure. As more fully described in the Technical Agreement, the Parties will discuss all manufacturing-related recalls through the JMC. Allos will handle all such recalls except that MMCO will handle any recalls in the
event that the manufacturing issues that are the basis for such recall are specific to the Licensed Territory and do not have any effect on the Allos Territory. 

  
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 7. INSURANCE. 

7.1 Each Party shall procure and maintain insurance, including product liability insurance, or shall self-insure, in each case in a manner
adequate to cover its obligations hereunder and consistent with normal business practices of prudent companies similarly situated at all times during which any Bulk Product or the labeled, packaged version thereof is being manufactured, clinically
tested or commercially distributed or sold by such Party. It is understood that such insurance shall not be construed to create a limit of either Party’s liability with respect to its indemnification obligations under Section 8 of this
Agreement. Each Party shall provide the other Party with written evidence of such insurance or self-insurance upon request. Each Party shall provide the other Party with written notice at least 30 days prior to the cancellation, non renewal or if
there is a material change in or to such insurance. 
 8. INDEMNIFICATION. 

8.1 Indemnification by Allos. Allos shall, at its sole expense, defend, indemnify, and hold MMCO and its Affiliates and their
respective officers, directors, employees, and agents (the “MMCO Indemnitees”) harmless from and against any and all Third Party claims, suits, proceedings, damages, losses, liabilities, costs, expenses (including court costs and
reasonable attorneys’ fees and expenses) and recoveries involving property damage or personal injury (including death) (collectively, “Claims”) to the extent that such Claims arise out of, are based on, or result from
(a) the breach of any of Allos’ representations and warranties set forth in Sections 9.1 or 9.3 and covenants under Sections 9.4(b)-(d) and 9.5, and (b) the willful misconduct or negligent acts of Allos, its Affiliates, or the
officers, directors, employees, or agents of Allos or its Affiliates. The foregoing indemnity obligation shall not apply (x) to the extent that (i) the MMCO Indemnitees fail to comply with the indemnification procedures set forth in
Section 8.3 and Allos’ defense of the relevant Claims is prejudiced by such failure or (ii) such Claims arise out of or result from the gross negligence or willful misconduct of the MMCO Indemnitees, or any related breach by MMCO of
its representations, warranties and/or covenants hereunder; or (y) to Claims for which MMCO has an obligation to indemnify Allos pursuant to Section 8.2, as to which Claims each Party shall indemnify the other to the extent of its
liability for such Claims. 
 8.2 Indemnification by MMCO. MMCO shall, at its sole expense, defend, indemnify, and hold
Allos and its Affiliates and their respective officers, directors, employees, and agents (the “Allos Indemnitees”) harmless from and against any and all Claims to the extent that such Claims arise out of, are based on, or result
from (a) the breach of any of MMCO’s representations and warranties set forth in Sections 9.2 or 9.3 and covenants under Section 9.5, and (b) the willful misconduct or negligent acts of MMCO, its Affiliates, or the officers,
directors, employees, or agents of MMCO or its Affiliates. The foregoing indemnity obligation shall not apply (x) to the extent that (i) the Allos Indemnitees fail to comply with the indemnification procedures set forth in Section 8.3
and MMCO’s defense of the relevant Claims is prejudiced by such failure or (ii) such Claims arise out of or result from the gross negligence or willful misconduct of the Allos Indemnitees, or any related breach by Allos of its
representations, warranties and/or covenants hereunder; or (y) to Claims for which Allos has an obligation to indemnify MMCO pursuant to Section 8.1, as to which Claims each Party shall indemnify the other to the extent of its liability
for such Claims. 

  
 28 

 8.3 Indemnification Procedures. The Party claiming indemnity under this
Section 8 (the “Indemnified Party”) shall give written notice to the Party from whom indemnity is being sought (the “Indemnifying Party”) promptly after learning of such Claim. The Indemnified Party shall
provide the Indemnifying Party with reasonable assistance, at the Indemnifying Party’s expense, in connection with the defense of the Claim for which indemnity is being sought. The Indemnified Party may participate in and monitor such defense
with counsel of its own choosing at its sole expense; provided, however, the Indemnifying Party shall have the right to assume and conduct the defense of the Claim with counsel of its choice. The Indemnifying Party shall not settle any
Claim without the prior written consent of the Indemnified Party, not to be unreasonably withheld, unless the settlement involves only the payment of money. So long as the Indemnifying Party is actively defending the Claim in good faith, the
Indemnified Party shall not settle or compromise any such Claim without the prior written consent of the Indemnifying Party. If the Indemnifying Party does not assume and conduct the defense of the Claim as provided above, (a) the Indemnified
Party may defend against, consent to the entry of any judgment, or enter into any settlement with respect to such Claim in any manner the Indemnified Party may deem reasonably appropriate (and the Indemnified Party need not consult with, or obtain
any consent from, the Indemnifying Party in connection therewith), and (b) the Indemnifying Party shall remain responsible to indemnify the Indemnified Party as provided in this Article 8. 

8.4 Allos’ Third Party Manufacturers. If a Third Party brings a Claim against an MMCO Indemnitee on account of
(i) failure of Bulk Product supplied by Allos pursuant to this Agreement to comply with GMP, (ii) Bulk Product supplied by Allos pursuant to this Agreement being Adulterated or Misbranded or (iii) the negligence, recklessness or
willful misconduct of Allos’ Third Party manufacturer, and such MMCO Indemnitee is not entitled to indemnification by Allos pursuant to Section 8.1 but Allos is entitled, pursuant to its supply agreement with the Third Party manufacturer
that produced such Bulk Product, to indemnification from such Third Party manufacturer on account of such non-compliance, Adulteration, Misbranding, negligence, recklessness or willful misconduct, then Allos shall, at MMCO’s request, pursue its
claim for indemnification from such Third Party manufacturer and shall pay to MMCO any amounts that Allos receives from such Third Party manufacturer on account of such indemnification claim, after deducting all legal fees and other reasonable
out-of-pocket costs incurred by Allos with respect to such pursuit. 
 9. REPRESENTATIONS AND WARRANTIES;
COVENANTS. 
 9.1 Representations and Warranties of Allos: Allos hereby represents and warrants to MMCO as
follows: 
 (a) As of the Effective Date, and as of the Amendment Effective Date, it is a company or corporation duly organized,
validly existing, and in good standing under the Laws of the jurisdiction in which it is incorporated or formed; 

  
 29 

 (b) As of the Effective Date, and as of the Amendment Effective Date, (i) it has the
corporate power and authority and the legal right to enter into this Agreement and perform its obligations hereunder; (ii) it has taken all necessary corporate action on its part required to authorize the execution and delivery of this
Agreement and the performance of its obligations hereunder; and (iii) this Agreement has been duly executed and delivered on behalf of Allos, and constitutes a legal, valid, and binding obligation of Allos that is enforceable against it in
accordance with its terms, subject as to enforcement of remedies to applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting generally the enforcement of creditors’ rights and subject to a court’s
discretionary authority with respect to the granting of a decree ordering specific performance or other equitable remedies; 

(c) To Allos’ Knowledge as of the Effective Date, and as of the Amendment Effective Date, the execution and performance of
Allos’ obligations hereunder do not and will not conflict with any material obligation it may have to any Third Party, and Allos does not and will not need the consent or approval of any Third Party or judicial or governmental agency to execute
this Agreement or perform any of its obligations hereunder; 
 (d) To Allos’ Knowledge as of the Effective Date, and as of
the Amendment Effective Date, there are no current investigations or claims against Allos in any court or by or before any governmental body or agency, with respect to manufacture or Allos’ commercial release of the Bulk Product or API, the
manufacturing facilities in which the Bulk Product or API is manufactured which may materially adversely affect Allos’ ability to perform its obligations under this Agreement; and 

(e) To Allos’ Knowledge as of the Effective Date, and as of the Amendment Effective Date, neither the Bulk Product nor the API is
currently the subject of any pending action, suit or other legal proceeding, or any written claim of infringement of the intellectual property rights of any Third Party. 
 9.2 Representations and Warranties of MMCO: MMCO represents and warrants to Allos as follows: 
 (a) As of the Effective Date, and as of the Amendment Effective Date, it is a partnership duly organized, validly existing, and in good standing under the Laws of the jurisdiction in which it is
incorporated or formed; 
 (b) As of the Effective Date, and as of the Amendment Effective Date, (i) it has the partnership
power and authority and the legal right to enter into this Agreement and perform its obligations hereunder; (ii) it has taken all necessary partnership action on its part required to authorize the execution and delivery of this Agreement and
the performance of its obligations hereunder; and (iii) this Agreement has been duly executed and delivered on behalf of MMCO, and constitutes a legal, valid, and binding obligation of MMCO that is enforceable against it in accordance with its
terms, subject as to enforcement of remedies to applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting generally the enforcement of creditors’ rights and subject to a court’s discretionary authority with
respect to the granting of a decree ordering specific performance or other equitable remedies; and 

  
 30 

 (c) To MMCO’s Knowledge, as of the Effective Date, and as of the Amendment Effective
Date, the execution and performance of MMCO’s obligations hereunder do not and will not conflict with any material obligation it may have to any Third Party, and MMCO does not and will not need the consent or approval of any Third Party or
judicial or governmental agency to execute this Agreement or perform any of its obligations hereunder. 
 9.3 Representations
and Warranties of the Parties. Each Party hereby represents and warrants to the other Party that, as of the Effective Date, and as of the Amendment Effective Date, none of such Party’s employees or consultants (i) are debarred under
Section 306(a) or 306(b) of the FD&C Act or by the applicable Laws of any Regulatory Authority; (ii) have, to such Party’s Knowledge, been charged with, or convicted of, any felony or misdemeanor within the ambit of 42 U.S.C.
§§ 1320a-7(a), 1320a-7(b)(l)-(3), or pursuant to the applicable Laws of any Regulatory Authority, or are proposed for exclusion, or the subject of exclusion or debarment proceedings by a Regulatory Authority, during the employee’s or
consultant’s employment or contract term; and (iii) are excluded, suspended or debarred from participation, or otherwise ineligible to participate, in any U.S. or non-U.S. health care programs (or have, to such Party’s Knowledge, been
convicted of a criminal offense that falls within the scope of 42 U.S.C. §1320a-7 but not yet excluded, debarred, suspended, or otherwise declared ineligible), or excluded, suspended or debarred by a Regulatory Authority from participation, or
otherwise ineligible to participate, in any procurement or nonprocurement programs. 
 9.4 Covenants of Allos. 

(a) Allos agrees that the Bulk Product and API delivered to MMCO under this Agreement (i) will meet the applicable Bulk Product
Specifications and API Specifications at the time of delivery, (ii) will remain in compliance with the Bulk Product Specifications and API Specifications throughout the shelf-life of the Bulk Product or API, as applicable, provided that it is
stored in strict compliance with the applicable long term storage conditions, it is not tampered with, damaged, modified, mishandled or used in a manner other than as intended, and (iii) will have been manufactured and stored by or for Allos in
conformity with GMPs and will not be Adulterated or Misbranded. 
 (b) Allos will use commercially reasonable efforts to ensure
the requisite manufacturing capacity to manufacture the Bulk Product and API under the terms of this Agreement. 
 (c) Prior to
the delivery of Bulk Product and API hereunder, Allos will have received, will be in current compliance with, and will use reasonable commercial efforts to maintain throughout the Term, all permits, licenses, registrations, and other forms of
governmental authorizations and approvals (“Permits”) required to be obtained and maintained by Allos in order for Allos to execute and deliver this Agreement and to perform its obligations hereunder in accordance with all
applicable Laws and will otherwise perform its obligations hereunder in a manner which complies in all material respects with applicable Laws. 
 (d) Allos shall be responsible for all process development and manufacturing scale-up activities, itself or through one or more of Allos’ Third Party manufacturers, required to produce commercial
quantities of the Bulk Product for eventual sale in the Licensed Territory. 

  
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 9.5 Covenants of the Parties.  

(a) During the Term, neither Party will utilize any employee or consultant (i) who has been debarred under Section 306(a) or
306(b) of the FD&C Act or pursuant to the applicable Laws of any Regulatory Authority; (ii) who, to such Party’s Knowledge, has been charged with, or convicted of, any felony or misdemeanor within the ambit of 42 U.S.C. §§
1320a-7(a), 1320a-7(b)(l)-(3), or otherwise pursuant to the applicable Laws of any Regulatory Authority, or is proposed for exclusion, or the subject of exclusion or debarment proceedings by a Regulatory Authority, during the employee’s or
consultant’s employment or contract term; or (iii) who is excluded, suspended or debarred from participation, or otherwise ineligible to participate, in any U.S. or non-U.S. health care programs (or who, to such Party’s Knowledge, has
been convicted of a criminal offense that falls within the scope of 42 U.S.C. §1320a-7 but has not yet been excluded, debarred, suspended, or otherwise declared ineligible), or excluded, suspended or debarred by a Regulatory Authority from
participation, or otherwise ineligible to participate, in any procurement or nonprocurement programs. Each Party shall notify the other Party promptly, but in no event later than five business days, upon becoming aware that any employee or
consultant it is using has been excluded, debarred, suspended or otherwise ineligible, or is the subject of exclusion, debarment or suspension proceedings by any Regulatory Authority. 

(b) Each Party will own all intellectual property it or its Affiliates or designees create in the course of performing this Agreement.

 9.6 Limitation on Liability. EXCEPT AS EXPRESSLY STATED IN THIS AGREEMENT (E.G., SECTIONS 9.1, 9.2 AND 9.3), NEITHER
PARTY MAKES ANY REPRESENTATIONS OR WARRANTIES WHATSOEVER TO THE OTHER, WHETHER EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, INCLUDING WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE,
NON-INFRINGEMENT, OR NON-MISAPPROPRIATION OF THIRD PARTY INTELLECTUAL PROPERTY RIGHTS, AND ALL REPRESENTATIONS AND WARRANTIES, WHETHER ARISING BY OPERATION OF LAW OR OTHERWISE, ARE HEREBY EXPRESSLY EXCLUDED. UNDER NO CIRCUMSTANCES SHALL MMCO HAVE
ANY LIABILITY TO ALLOS’ THIRD PARTY MANUFACTURERS OF BULK PRODUCT OR API UNDER THIS AGREEMENT. EXCEPT WITH RESPECT TO THIRD PARTY CLAIMS FOR PERSONAL INJURY ARISING OUT OF (I) ALLOS’ SOLE NEGLIGENCE OR WILLFUL MISCONDUCT UNDER
SECTION 8.1, OR (II) THE RIGHTS OR OBLIGATIONS OF ANY PARTY UNDER SECTION 8.4 (FOR PURPOSES OF CLARITY, ALLOS DOES NOT HAVE ANY OBLIGATION UNDER SECTION 8.4 TO PROVIDE TO MMCO ANY AMOUNTS THAT ARE NOT RECEIVED BY ALLOS FROM THE APPLICABLE THIRD
PARTY MANUFACTURER), UNDER NO CIRCUMSTANCES WILL ALLOS’ AGGREGATE LIABILITY TO MMCO OR ITS AFFILIATES WITH RESPECT TO THIS AGREEMENT EXCEED THE TOTAL PAYMENTS MADE BY MMCO IN THE CALENDAR YEAR IN WHICH THE ACTION OCCURRED. 

 9.7 DISCLAIMER. NEITHER PARTY SHALL BE LIABLE TO THE OTHER FOR ANY SPECIAL, CONSEQUENTIAL, INCIDENTAL, PUNITIVE, OR
INDIRECT DAMAGES ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. 

  
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NOTWITHSTANDING THE FOREGOING, NOTHING IN THIS SECTION 9.7 IS INTENDED TO OR SHALL LIMIT OR RESTRICT THE INDEMNIFICATION RIGHTS OR OBLIGATIONS OF ANY PARTY UNDER SECTION 8.1 OR 8.2 OR THE RIGHTS
OR OBLIGATIONS OF ANY PARTY UNDER SECTION 8.4 (FOR PURPOSES OF CLARITY, ALLOS DOES NOT HAVE ANY OBLIGATION UNDER SECTION 8.4 TO PROVIDE TO MMCO ANY AMOUNTS THAT ARE NOT RECEIVED BY ALLOS FROM THE APPLICABLE THIRD PARTY MANUFACTURER). 

9.8 Sole Remedy. Allos’ sole liability and MMCO’s sole remedy for any breach of the representations set forth in
Section 9.4(a) shall be as set forth in Section 3.11. Allos’ sole liability and MMCO’s sole remedy for any failure of Allos to deliver any Bulk Product or API set forth in any Firm Order therefor shall be as set forth in Sections
4.1 and 4.2. Notwithstanding the foregoing, nothing in this Section 9.8 is intended to or shall limit or restrict the indemnification rights or obligations of any Party under Section 8.1 or 8.2 or the rights or obligations of any Party
under Section 8.4 (For purposes of clarity, Allos does not have any obligation under Section 8.4 to provide to MMCO any amounts that are not received by Allos from the applicable Third Party manufacturer). 

10. TERMINATION. 
 10.1 Cross-Termination. This Agreement will terminate automatically upon the termination of the License Agreement or upon the signed written agreement of the Parties. 

10.2 Termination for Breach. Each Party (the “Non-Breaching Party”) shall have the right to terminate this
Agreement in its entirety immediately upon written notice to the other Party (the “Breaching Party”) if the Breaching Party materially breaches its obligations under this Agreement and, after receiving written notice identifying
such material breach in reasonable detail (a “Default Notice”), fails to cure such material breach within [***] after delivery of the Default Notice. 
 10.3 Termination for Bankruptcy. Each Party shall have the right to terminate this Agreement in its entirety immediately upon written notice to the other Party if the other Party (i) applies
for or consents to the appointment of, or the taking of possession by, a receiver, custodian, trustee or liquidator of itself or of all or a substantial part of its property, (ii) makes a general assignment for the benefit of its creditors,
(iii) commences a voluntary case under the Bankruptcy Code, (iv) files a petition seeking to take advantage of any applicable Laws relating to bankruptcy, insolvency, reorganization, winding-up, or composition or readjustment of debts,
(v) has a proceeding or case commenced against it in any court of competent jurisdiction (which proceeding or case is not discharged within 60 days of the filing thereof), seeking (A) its liquidation, reorganization, dissolution or
winding-up, or the composition or readjustment of its debts, (B) the appointment of a trustee, receiver, custodian, liquidator or the like of all or any substantial part of its assets, or (C) similar relief under the Bankruptcy Code, or an
order, judgment or decree approving any of the foregoing is entered and continues unstayed for a period of 60 days, or (vi) has an order for relief against it entered in an involuntary case under the Bankruptcy Code. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
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 10.4 Post-Termination. Expiration or termination of this Agreement will not relieve
the Parties of any obligations accruing prior to such expiration or termination. 
 11. CONFIDENTIALITY.

 11.1 Confidentiality. Each Party agrees that, for the longer of the Term or the term of the License Agreement and for a
period of five years thereafter, it shall keep confidential and shall not publish or otherwise disclose and shall not use for any purpose other than as provided for in this Agreement (which includes the exercise of any rights or the performance of
any obligations hereunder or thereunder) any Confidential Information furnished to it by the other Party pursuant to this Agreement, except to the extent expressly authorized by this Agreement or as otherwise agreed to in writing by the Parties. The
foregoing confidentiality and non-use obligations shall not apply to any portion of the other Party’s Confidential Information that the receiving Party can demonstrate by competent written proof: 

(a) was already known to the receiving Party or its Affiliate, other than under an obligation of confidentiality, at the time of
disclosure by the other Party; 
 (b) was generally available to the public or otherwise part of the public domain at the time of
its disclosure to the receiving Party; 
 (c) became generally available to the public or otherwise part of the public domain
after its disclosure and other than through any act or omission of the receiving Party in breach of this Agreement; 
 (d) was
disclosed to the receiving Party or its Affiliate by a Third Party who had a legal right to make such disclosure and who did not obtain such information directly or indirectly from the other Party; or 

(e) was independently discovered or developed by the receiving Party or its Affiliate without access to or aid, application or use of the
other Party’s Confidential Information, as evidenced by a contemporaneous writing. 
 11.2 Authorized Disclosure.
Notwithstanding the obligations set forth in Section 11.1, a Party may disclose the other Party’s Confidential Information and the terms of this Agreement to the extent: 

(a) such disclosure is reasonably necessary (i) to comply with the requirements of Regulatory Authorities with respect to obtaining
and maintaining Regulatory Approval of the Bulk Product or the API; or (ii) for prosecuting or defending litigation as contemplated by this Agreement or the License Agreement; 

(b) such disclosure is reasonably necessary to its officers, directors, employees, agents, consultants, contractors, licensees,
sublicensees, attorneys, accountants, lenders, insurers or licensors on a need-to-know basis for the sole purpose of performing its obligations or exercising its rights under this Agreement; provided that in each case, the disclosees are bound by
obligations of confidentiality and non-use no less stringent than those contained in this Agreement; 

  
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 (c) such disclosure is reasonably necessary to any bona fide potential or actual investor,
acquiror, merger partner, or other financial or commercial partner for the sole purpose of evaluating an actual or potential investment, acquisition or other business relationship; provided that in each case, the disclosees are bound by written
obligations of confidentiality and non-use having a minimum term of five years; or 
 (d) such disclosure is reasonably necessary
to comply with applicable Laws, including regulations promulgated by applicable security exchanges, court order, administrative subpoena or other order. 
 Notwithstanding the foregoing, in the event a Party is required to make a disclosure of the other Party’s Confidential Information pursuant to Section 11.2(a) or 11.2(d), such Party shall
promptly notify the other Party of such required disclosure and, upon the other Party’s request, shall use reasonable efforts to obtain, or to assist the other Party in obtaining, a protective order preventing or limiting the required
disclosure. 
 11.3 Prior Confidentiality Agreements. The First Confidentiality Agreement and the Second
Confidentiality Agreement remain in full force and effect and are not superseded by this Agreement. All Information disclosed by a Party or its Affiliate to the other Party or its Affiliate pursuant to the First Confidentiality Agreement or the
Second Confidentiality Agreement shall be deemed to be such Party’s Confidential Information disclosed hereunder and the other Party and its Affiliates and disclosees shall have the confidentiality, non-use and non-disclosure obligations set
forth in this Article 11. In the event that any such obligations conflict with the obligations set forth in the First Confidentiality Agreement or the Second Confidentiality Agreement, then the other Party and its Affiliates and disclosees shall
comply with the obligations set forth in this Article 11. 
 11.4 Return of Confidential Information. Except as otherwise
set forth in this Agreement, upon termination of this Agreement, the receiving Party will promptly return all of the disclosing Party’s Confidential Information, including all reproductions and copies thereof in any medium, except that the
receiving Party may retain one copy for its legal files. 
 11.5 Unauthorized Use. If either Party becomes aware or has
Knowledge of any unauthorized use or disclosure of the other Party’s Confidential Information, it will promptly notify the other Party of such unauthorized use or disclosure. 

11.6 Exclusive Property. All Confidential Information is the sole and exclusive property of the disclosing Party and the
permitted use thereof by the receiving Party for purposes of its performance hereunder will not be deemed a license or other right of the receiving Party to use any such Confidential Information for any other purpose. 

11.7 Terms of Agreement. The Parties agree that the material terms of this Agreement are the Confidential Information of both
Parties. 

  
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 12. DISPUTE RESOLUTION. 

12.1 Arbitration. In the event of any disputes, controversies or differences which may arise between the Parties (except for
disputes arising from the JMC, which shall be handled pursuant to Section 12.2 and only handled pursuant to this Section 12.1 as provided in Section 12.2), out of or in relation to or in connection with this Agreement, including any
alleged failure to perform, or breach, of this Agreement, or any issue relating to the interpretation or application of this Agreement, then upon the request of either Party, the Parties agree to meet and discuss in good faith a possible resolution
thereof, which good faith efforts shall include at least one in-person meeting between the Executive Officers of each Party. If the matter is not resolved within [***] following the request for discussions, either Party may then invoke arbitration
under this Section 12.1. Any dispute, controversy or claim arising out of or relating to the validity, construction, interpretation, enforceability, breach, performance, application or termination of this Agreement that is not resolved pursuant
to Section 12.2 or by the Parties meeting in good faith to resolve such dispute, controversy or claim as outlined above, shall be settled by binding arbitration administered by JAMS pursuant to its Comprehensive Arbitration Rules and Procedures
then in effect (the “JAMS Rules”), except as otherwise provided herein. The arbitration will be conducted in New York, New York and the Parties consent to the personal and subject matter jurisdiction of the state and federal courts
in New York, New York, for any case arising out of or otherwise related to this arbitration, its conduct and its enforcement. Any situation not expressly covered by this Agreement shall be decided in accordance with the JAMS Rules. 

12.2 Referred from JMC. With respect to disputes arising from matters delegated or referred to the JMC pursuant to the terms of
this Agreement, such dispute shall be automatically referred to the JPC. If the JPC fails to reach unanimous agreement on such matter within [***], then either Party may, by written notice to the other Party, have such dispute referred to each
Party’s Executive Officers for attempted resolution by good faith negotiations within [***] after such notice is received. If the Executive Officers of the Parties are not able to resolve a dispute within the [***] period described above, then
the Executive Officers of Allos will have the unilateral right to cast the deciding vote for the JMC as provided in Section 12.2(a): 
 (a) Allos Decisions. Solely with respect to Bulk Product or API supplied by or on behalf of Allos, the Executive Officers of Allos shall have the right to make the final decision with respect to
any decision regarding manufacture of the Bulk Product or API (including matters related to CMC, process development, scale up, or regulatory matters or aspects related to manufacture of the Bulk Product), except where MMCO reasonably believes
either that such decision is substantially likely to cause a material adverse impact on the regulatory status or the commercial sales of the Bulk Product in the Licensed Territory and would not have a similar effect in the Allos Territory or that
such decision poses a substantial and unwarranted safety risk. 
 If the Executive Officers of Allos do not have the right to
cast the deciding vote for the JMC pursuant to this Section 12.2, then either Party may submit the dispute for resolution pursuant to Section 12.1. 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  
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 12.3 Equitable Relief. Notwithstanding Sections 12.1 and 12.2, each Party
acknowledges that its breach of Article 11 of this Agreement may cause irreparable harm to the other Party, which cannot be reasonably or adequately compensated by damages in an action at law. By reason thereof, each Party agrees that the other
Party shall be entitled, in addition to any other remedies it may have under this Agreement or otherwise, to seek preliminary and permanent injunctive and other equitable relief from any state or federal court of competent jurisdiction in New York,
New York to prevent or curtail any actual or threatened breach of Article 11 that is reasonably likely to cause it irreparable harm. In addition, notwithstanding Sections 12.1 and 12.2, to the fullest extent provided by Law, either Party may bring
an action in any court of competent jurisdiction for injunctive relief (or any other provisional remedy) to protect a Party’s rights or enforce a Party’s obligations under this Agreement pending final resolution of any claims related
thereto pursuant to the dispute resolution procedure set forth in Sections 12.1 and 12.2. 
 13. INDEPENDENT CONTRACTOR.
Each Party shall act solely as an independent contractor, and nothing in this Agreement shall be construed to give either Party the power or authority to act for, bind, or commit the other Party in any way. Nothing herein shall be construed to
create the relationship of partners, principal and agent, or joint-venture partners between the Parties. 
 14.
MISCELLANEOUS. 
 14.1 Force Majeure. Both Parties shall be excused from the performance of their
obligations under this Agreement to the extent that such performance is prevented by force majeure and the non-performing Party promptly provides notice of the prevention to the other Party. Such excuse shall continue for so long as the condition
constituting force majeure continues and the non-performing Party takes reasonable efforts to remove the condition. For purposes of this Agreement, force majeure shall include conditions beyond the control of the Parties, including an act of God,
war, civil commotion, terrorist act, epidemic, failure or default of public utilities or common carriers, destruction of production facilities or materials by fire, earthquake, storm or like catastrophe, and failure of plant or machinery (provided
that such failure could not have been prevented by the exercise of skill, diligence, and prudence that would be reasonably and ordinarily expected from a skilled and experienced person engaged in the same type of undertaking under the same or
similar circumstances). If a force majeure persists for more than 90 days, then the Parties will discuss in good faith the modification of the Parties’ obligations under this Agreement in order to mitigate the delays caused by such force
majeure. 
 14.2 Assignment. Neither Party may assign or transfer this Agreement or any rights or obligations hereunder
without the prior written consent of the other Party, except that a Party may make such an assignment without the other Party’s consent to its Affiliates or to a Third Party successor to substantially all of the business of such Party to which
this Agreement relates (such Third Party, an “Acquiror”), whether in a merger, sale of stock, sale of assets or other transaction. Any successor or assignee of rights and/or obligations permitted hereunder shall, in writing to the
other Party, expressly assume performance of such rights and/or obligations. Unless to an Affiliate, any assignment or transfer of this Agreement must be done together with an assignment or transfer of the License Agreement. Any permitted assignment
shall be binding on the successors of the assigning Party. Any assignment or attempted assignment by either Party in violation of the terms of this Section 14.2 shall be null, void and of no legal effect. 

  
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 14.3 Governing Law. This Agreement and all disputes arising out of or related to this
Agreement or any breach hereof shall be governed by and construed under the laws of the State of New York, without giving effect to any choice of law principles that would require the application of the laws of a different state. 

14.4 Notices. Any notice required or permitted to be given under this Agreement shall be in writing, shall specifically refer to
this Agreement, and shall be addressed to the appropriate Party at the address specified below or such other address as may be specified by such Party in writing in accordance with this Section 14.4, and shall be deemed to have been given for
all purposes (a) when received, if hand-delivered or sent by confirmed facsimile or a reputable courier service, or (b) five business days after mailing, if mailed by first class certified or registered airmail, postage prepaid, return
receipt requested. 
 If to Allos: 
 Allos Therapeutics, Inc. 
 11080 Circle Point Road, 

Suite 430 

Westminster, Colorado 80020 
 Attn: President and Secretary 
 Fax: (303) 426-4731 

With copies to (which shall not constitute notice): 
 Allos Therapeutics, Inc. 
 11080 Circle Point Road, 

Suite 430 

Westminster, Colorado 80020 
 Attn: Legal Department 
 Fax: (303) 426-4731 

Stradling Yocca Carlson & Rauth 
 660 Newport Center Drive, Suite 1600 
 Newport Beach, CA 92660 

Attn: Shivbir S. Grewal 
 Fax: (949) 823-5119 
 If to MMCO: 

Mundipharma Medical Company 
 14 Par-la-Ville Road 
 P.O. Box HM 2332 

Hamilton HM JX, Bermuda 
 Attn: Douglas Docherty, General Manager 
 Fax: (441) 292-1472 

  
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 With copies to (which shall not constitute notice): 

Chadbourne & Parke LLP 
 30 Rockefeller Plaza 
 New York, NY 10112 

Attention: Stuart D. Baker 
 Fax: (212) 489-7130 
 or to such other fax number and address as such Party receiving such
notice will have communicated to the other Party hereto by notice given as aforesaid. 
 14.5 Counterparts. This Agreement
may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Each Party may execute this Agreement by facsimile transmission or in AdobeTM
Portable Document Format (PDF) sent by electronic mail. In addition, facsimile or PDF signatures of authorized signatories of any Party will be deemed to be original signatures and will be valid and binding, and delivery of a facsimile or PDF
signature by any Party will constitute due execution and delivery of this Agreement. 
 14.6 Entire Agreement; Amendment.
This Agreement, as amended and restated as of the Amendment Effective Date, including the Exhibits hereto, together with the License Agreement, the Consent, the Technical Agreement and the Pharmacovigilance Agreements, sets forth the complete, final
and exclusive agreement and all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties hereto with respect to the subject matter hereof and supersedes, as of the Amendment Effective Date,
all prior and contemporaneous agreements and understandings between the Parties with respect to the subject matter hereof. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or
written, between the Parties with respect to the subject matter of this Agreement other than as are set forth in this Agreement, the License Agreement, the Technical Agreement or the Pharmacovigilance Agreements. No subsequent alteration, amendment,
change or addition to this Agreement shall be binding upon the Parties unless reduced to writing and signed by an authorized officer of each Party. 
 14.7 Survival. Termination or expiration of this Agreement shall not affect rights or obligations of the Parties under this Agreement that have accrued prior to the date of termination or
expiration. Notwithstanding anything to the contrary contained in this Agreement, the provisions of those Sections which by their nature are meant to survive termination will survive any expiration or termination of this Agreement. 

14.8 Further Actions. Each Party agrees to execute, acknowledge and deliver such further instruments, and to do all such other
acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement. 

  
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 14.9 Severability. If any one or more of the provisions of this Agreement is held to
be invalid or unenforceable by any court of competent jurisdiction from which no appeal can be or is taken, the provision shall be considered severed from this Agreement and shall not serve to invalidate any remaining provisions hereof. The Parties
shall make a good faith effort to replace any invalid or unenforceable provision with a valid and enforceable one such that the objectives contemplated by the Parties when entering this Agreement may be realized. 

14.10 No Waiver. Any delay in enforcing a Party’s rights under this Agreement or any waiver as to a particular default or
other matter shall not constitute a waiver of such Party’s rights to the future enforcement of its rights under this Agreement, except with respect to an express written and signed waiver relating to a particular matter for a particular period
of time. 
 14.11 Expenses. Each of the Parties will bear its own direct and indirect expenses incurred in connection with
the negotiation and preparation of this Agreement and, except as set forth in this Agreement, the performance of the obligations contemplated hereby and thereby. 
 14.12 Currency. All payment amounts set forth herein, and all obligations of Allos and MMCO relating to the payment or receipt of money, are expressed in and will be paid in Euros by wire transfer
of immediately available funds into an account designated by Allos. 
 14.13 Performance by Affiliates. Each Party may
discharge any obligations and exercise any right hereunder through any of its Affiliates. Each Party hereby guarantees the performance by its Affiliates of such Party’s obligations under this Agreement, and shall cause its Affiliates to comply
with the provisions of this Agreement in connection with such performance. Any breach by a Party’s Affiliate of any of such Party’s obligations under this Agreement shall be deemed a breach by such Party, and the other Party may proceed
directly against such Party without any obligation to first proceed against such Party’s Affiliate. 
 [remainder of this
page intentionally left blank] 

  
 40 

 IN WITNESS WHEREOF, the Parties hereto have caused this Amended and Restated Supply
Agreement to be executed by their duly authorized representatives as of the Amendment Effective Date. 
  

			
	MUNDIPHARMA MEDICAL COMPANY
		
	 By:
	 	 /s/ Douglas Docherty

		 	 Name: Douglas Docherty

		 	 Title: General Manager

	
	ALLOS THERAPEUTICS, INC.
		
	 By:
	 	 /s/ Abraham N. Oler

		 	 Name: Abraham N. Oler

		 	 Title: President and Secretary

 EXHIBIT A 
 BULK PRODUCT SPECIFICATIONS AND API SPECIFICATIONS 
 Bulk Product Specification

 [***] 
 API Specification

 [***] 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  

 EXHIBIT B 
 TECHNICAL AGREEMENT 
 [***] 

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION. 
  

 EXHIBIT C 

SPREADSHEET WITH SAMPLE CALCULATION OF BULK PRODUCT ACTUAL 

DIRECT COST OR BULK PRODUCT ANTICIPATED DIRECT COST 
 SAMPLE CALCULATION OF ANTICIPATED OR ACTUAL BULK PRODUCT TRANSFER PRICE (ALL FIGURES ILLUSTRATIVE) 
  

					
	 	  	Estimated	 
	 Total vials actually or anticipated to be made and available for commercial or clinical supply
	  			
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
		  	  
	  
	 
	 Total Units
	  	 	[***]	  
		  	  
	  
	 
	 Other Direct Costs
	  			
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
		  	  
	  
	 
	 Total Other Direct
	  	$	[***]	  
		  	  
	  
	 
	 Other direct per unit
	  	$	[***]	  
		  	  
	  
	 
	 [***] Direct (Purchased) Cost per Actually or Anticipated to be Made and Available Unit
	  			
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
	 - Total Direct Cost / [***]
	  	$	[***]	  
	 [***] Direct (Purchased) Cost per Actually or Anticipated to be Made and Available Unit
	  			
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
	 [***]
	  	$	[***]	  
	 - Total Direct Cost / [***]
	  	$	[***]	  
	 Assumes all units shipped are billed upon shipment terms [***]
	  			

  
 [***]: CONFIDENTIAL
PORTIONS OMITTED AND FILED SEPARATELY WITH THE COMMISSION.

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