Document:

EX-10.7

 Exhibit 10.7 

EXECUTIVE EMPLOYMENT AGREEMENT 

for 
 David Renzi 

This Executive Employment Agreement (the “Agreement”) is made between Carbylan BioSurgery, Inc. (the
“Company”) and David Renzi (‘‘Executive”)(collectively, the ‘‘Parties”). 

WHEREAS, the Company desires for Executive to provide services to the Company, and wishes
to provide Executive with certain compensation and benefits in return for such employment services; and 

WHEREAS, Executive wishes to be employed by the Company and to provide personal services
to the Company in return for certain compensation and benefits; 
 NOW,
THEREFORE, in consideration of the mutual promises and covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Parties hereto agree
as follows: 
 1. Employment by the Company. 

1.1  Position.  Executive shall serve as the Company’s Chief Executive Officer and President.
During the term of Executive’s employment with the Company, Executive will devote Executive’s best efforts and substantially all of Executive’s business time and attention to the business of the Company, except for approved vacation
periods and reasonable periods of illness or other incapacities permitted by the Company’s general employment policies. Executive shall begin his employment with the Company on June 3, 2013. 

1.2  Board Position.  Executive shall serve as a director on the Company’s Board of Directors
(the “Board”) for so long as he remains employed in the position of President and Chief Executive Officer. If Executives ceases to serve in such positions for any reason, then Executive will resign from his position on the Board.

 1.3  Duties and Location.  Executive shall perform such duties as are required by the Board,
to whom Executive will report. Executive’s primary office location shall be the Company’s Palo Alto office. The Company reserves the right to reasonably require Executive to perform Executive’s duties at places other than
Executive’s primary office location from time to time, and to require reasonable business travel. 

1.3  Policies and Procedures.  The employment relationship between the Parties shall be governed
by the general employment policies and practices of the Company, except that when the terms of this Agreement differ from or are in conflict with the Company’s general employment policies or practices, this Agreement shall control. 

2. Compensation. 

2.1  Salary.  For services to be rendered hereunder, Executive shall receive a base salary at the
rate of Three Hundred Fifty Thousand dollars ($350,000) per year (the “Base Salary”), subject to standard 

 
payroll deductions and withholdings and payable in accordance with the Company’s regular payroll schedule. 

2.2  Bonus.  Executive will be eligible for an annual discretionary target bonus of Twenty Percent (20%) of
Executive’s Base Salary (the “Annual Bonus”). Whether Executive receives an Annual Bonus for any given year, and the amount of any such Annual Bonus, will be determined by the Board in its sole discretion based upon the
Company’s and Executive’s achievement of objectives and milestones to be determined on an annual basis by the Board in consultation with Executive. Executive must remain an active employee through the end of any given calendar year in
order to earn an Annual Bonus for that year and any such bonus will be paid prior to March 15 of the year following the year in which Executive’s right to such amount became vested. Executive will not be eligible for, and will not earn,
any Annual Bonus (including a prorated bonus) if Executive’s employment terminates for any reason before the end of the calendar year. 

2.3  Standard Company Benefits.  Executive shall be entitled to participate in all employee
benefit programs for which Executive is eligible under the terms and conditions of the benefit plans that may be in effect from time to time and provided by the Company to its employees. The Company reserves the right to cancel or change the benefit
plans or programs it offers to its employees at any time. 
 2.4  Option Grant.  Subject to
approval by the Board, Executive shall be granted an option to purchase 2,103,305 shares of Common Stock in the Company at the fair market value on the date of grant (the “Option”). The Option shall be governed in all respects by
the terms of the governing plan documents and option agreement between Executive and the Company, which shall provide for the following vesting schedule;
 1⁄4 of the shares subject to the Option shall vest one (1) year after grant, with the remaining shares vesting in equal monthly installments over
the three (3) years thereafter. The Option Agreement shall also provide, among other things, that all shares shall immediately vest in the event of a Change in Control in which the Option is not assumed by the acquiring company. Future option
grants may be offered by the Board to the Executive in its discretion. 
 3. Termination of Employment; Severance.

 3.1  At-Will Employment.  Executive’s employment relationship is at-will. Either
Executive or the Company may terminate the employment relationship at any time, with or without Cause or advance notice. 

3.2  Termination Without Cause. 

(i)  The Company may terminate Executive’s employment with the Company at any time without Cause (as defined
below). 
 (ii)  In the event Executive’s employment with the Company is terminated by the Company without
Cause, then provided such termination constitutes a “separation from service” (as defined under Treasury Regulation Section 1.409A-1(h), without regard to any alternative definition thereunder, a

  

 
“Separation from Service”), and Executive remains in compliance with the terms of this Agreement, the Company shall provide Executive with the following Severance Benefits: 

(a) The Company shall pay Executive, as severance, one (1) year of Executive’s base salary in effect as of the date
of Executive’s employment termination, subject to standard payroll deductions and withholdings (the “Severance”). The Severance will be paid in equal installments on the Company’s regular payroll schedule over the one
(1) year period following Executive’s Separation from Service; provided, however, that no payments will be made prior to the 60th day following Executive’s Separation from Service. On the 60th day
following Executive’s Separation from Service, the Company will pay Executive in a lump sum the Severance that Executive would have received on or prior to such date under the original schedule but for the delay while waiting for the 60th day
in compliance with Internal Revenue Code Section 409A and the effectiveness of the Separation Agreement referenced in Section 4 below, with the balance of the Severance being paid as originally scheduled. 

(b) Provided Executive timely elects continued coverage under COBRA, the Company shall pay the COBRA premiums to continue
Executive’s coverage (including coverage for eligible dependents, if applicable) (“COBRA Premiums”) through the period (the “COBRA Premium Period”) starting on the Executive’s Separation from Service and
ending on the earliest to occur of: (i) one year following Executive’s Separation from Service; (ii) the date Executive becomes eligible for group health insurance coverage through a new employer; or (iii) the date Executive
ceases to be eligible for COBRA continuation coverage for any reason. In the event Executive becomes covered under another employer’s group health plan or otherwise cease to be eligible for COBRA during the COBRA Premium Period, Executive must
immediately notify the Company of such event. Notwithstanding the foregoing, if the Company determines, in its sole discretion, that it cannot pay the COBRA Premiums without a substantial risk of violating applicable law (including, without
limitation, Section 2716 of the Public Health Service Act), the Company instead shall pay to Executive, on the first day of each calendar month, a fully taxable cash payment equal to the applicable COBRA Premiums for that month, subject to
applicable tax withholdings, for the remainder of the COBRA Premium Period, which Executive may, but is not obligated to, use toward the cost of COBRA Premiums. 

(c) The vesting of Executive’s Option and any other options then held by Executive shall be accelerated such that the
shares subject thereto that would have vested in the one (1) year period following Executive’s Separation from Service had Executive’s employment not been terminated shall be deemed vested and exercisable as of Executive’s last
day of employment (the “Accelerated Vesting”); provided, however, that if the termination without Cause occurs either three (3) months prior to or within one (1) year after the effective
date of a Change in Control (as defined below), then 100% of the shares subject to the Option and any other options then held by Executive shall be deemed vested and exercisable as of Executive’s last day of employment. 

3.3 Resignation. 

(i)  Executive may resign from Executive’s employment with the Company at any time, with or without Good
Reason (as defined below). 

  

 (ii)  In the event Executive resigns for Good Reason, then provided
such termination constitutes a Separation from Service, and Executive remains in compliance with the terms of this Agreement, the Company shall provide Executive with the Severance set forth in Section 3.2(ii)(a) above, as well as the COBRA
Premiums set forth above in Section 3.2(ii)(b) and the accelerated vesting set forth above in Section 3.2(ii)(c). 

(iii)  In the event Executive resigns without Good Reason, then (i) Executive will no longer vest in the
Option, (ii) all payments of compensation by the Company to Executive hereunder will terminate immediately (except as to amounts already earned), and (c) Executive will not be entitled to any severance benefits, including (without
limitation) the Severance, COBRA Premiums, or Accelerated Vesting. 
 3.4 Termination for Cause; Death or
Disability. 
 (i)  The Company may terminate Executive’s employment with the Company at any time
for Cause. Executive’s employment with the Company may also be terminated due to Executive’s death or disability. 

(ii)  If the Company terminates Executive’s employment for Cause, or upon Executive’s death or
disability, then (i) Executive will no longer vest in the Option, (ii) all payments of compensation by the Company to Executive hereunder will terminate immediately (except as to amounts already earned), and (c) Executive will not be
entitled to any severance benefits, including (without limitation) the Severance, COBRA Premiums, or Accelerated Vesting. 

4. Conditions to Receipt of Severance, COBRA Premiums, and Accelerated Vesting. The receipt of the Severance, COBRA
Premiums, and Accelerated Vesting will be subject to Executive signing and not revoking a separation agreement and release of claims in a form reasonably satisfactory to the Company (the “Separation Agreement”). No
Severance, COBRA Premiums, or Accelerated Vesting will be paid or provided until the Separation Agreement becomes effective. As a further condition to the receipt of any severance benefits set forth in this Agreement, Executive shall also be
required to resign from all positions and terminate any relationships as an employee, advisor, officer or director with the Company and any of its affiliates, each effective on the date of termination. 

5. Section 409A.    It is intended that all of the severance benefits and other
payments payable under this Agreement satisfy, to the greatest extent possible, the exemptions from the application of Code Section 409A provided under Treasury Regulations 1.409A1(b)(4), 1.409A1(b)(5) and 1.409A1(b)(9), and this Agreement will
be construed to the greatest extent possible as consistent with those provisions, and to the extent no so exempt, this Agreement (and any definitions hereunder) will be construed in a manner that complies with Section 409A. For purposes of Code
Section 409A (including, without limitation, for purposes of Treasury Regulation Section 1.409A2(b)(2)(iii)), Executive’s right to receive any installment payments under this Agreement (whether severance payments, reimbursements or
otherwise) shall be treated as a right to receive a series of separate payments and, accordingly, each installment payment hereunder shall at all times be considered a separate and distinct payment. 

  

 
Notwithstanding any provision to the contrary in this Agreement, if Executive is deemed by the Company at the time of Executive’s Separation from Service to be a “specified
employee” for purposes of Code Section 409A(a)(2)(B)(i), and if any of the payments upon Separation from Service set forth herein and/or under any other agreement with the Company are deemed to be “deferred compensation”, then to
the extent delayed commencement of any portion of such payments is required in order to avoid a prohibited distribution under Code Section 409A(a)(2)(B)(i) and the related adverse taxation under Section 409A, such payments shall not be
provided to Executive prior to the earliest of (i) the expiration of the six-month period measured from the date of Executive’s Separation from Service with the Company, (ii) the date of Executive’s death or (iii) such
earlier date as permitted under Section 409A without the imposition of adverse taxation. Upon the first business day following the expiration of such applicable Code Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this
Paragraph shall be paid in a lump sum to Executive, and any remaining payments due shall be paid as otherwise provided herein or in the applicable agreement. No interest shall be due on any amounts so deferred. 

6. Definitions. 

(i)  Cause.  For purposes of this Agreement, “Cause” for termination will mean:
(a) commission of any felony or crime involving dishonesty; (b) participation in any fraud against the Company; (c) material breach of Executive’s duties to the Company; (d) persistent and material unsatisfactory performance
of job duties after detailed written notice from the Board and a reasonable opportunity to cure; or (e) material misconduct or other violation of Company policy that causes material harm to the Company. 

(ii)  Good Reason.  For purposes of this Agreement, Executive shall have “Good
Reason” for resignation from employment with the Company if any of the following actions are taken by the Company without Executive’s prior written consent: (a) a material reduction in Executive’s base salary, which the
parties agree is a reduction of at least 10% of Executive’s base salary; (b) a material reduction in Executive’s duties (including responsibilities and/or authorities), provided, however, that a change in job
position (including a change in title) shall not be deemed a “material reduction” in and of itself unless Executive’s new duties are materially reduced from the prior duties; or (c) relocation of Executive’s principal place
of employment to a place that increases Executive’s one-way commute by more than thirty-five (35) miles as compared to Executive’s then-current principal place of employment immediately prior to such relocation. In order to resign for
Good Reason, Executive must provide written notice to the Company’s Chairman within 45 days after he first has knowledge of the occurrence of the event giving rise to Good Reason setting forth the basis for Executive’s resignation, allow
the Company at least 45 days from receipt of such written notice to cure such event, and if such event is not reasonably cured within such period, Executive must resign from all positions Executive then holds with the Company not later than 45 days
after the expiration of the cure period. 
 6.2  Change in Control.  For purposes of this
Agreement, “Change in Control” shall have the definition set forth in the Carbylan BioSurgery, Inc. Amended and Restated 2004 Stock Option Plan. 

  

 7. Proprietary Information Obligations. 

7.1  Confidential Information Agreement.  As a condition of employment, Executive shall
execute and abide by the Company’s standard form of Employee Proprietary Information and Inventions Agreement (the “Confidentiality Agreement”). 

7.2  Third-Party Agreements and Information.  Executive represents and warrants that
Executive’s employment by the Company does not conflict with any prior employment or consulting agreement or other agreement with any third party, and that Executive will perform Executive’s duties to the Company without violating any such
agreement. Executive represents and warrants that Executive does not possess confidential information arising out of prior employment, consulting, or other third party relationships, that would be used in connection with Executive’s employment
by the Company, except as expressly authorized by that third party. During Executive’s employment by the Company, Executive will use in the performance of Executive’s duties only information which is generally known and used by persons
with training and experience comparable to Executive’s own, common knowledge in the industry, otherwise legally in the public domain, or obtained or developed by the Company or by Executive in the course of Executive’s work for the
Company. 
 8. Outside Activities During Employment. 

8.1  Non-Company Business.  Except with the prior written consent of the Board, Executive will not
during the term of Executive’s employment with the Company undertake or engage in any other employment, occupation or business enterprise, other than ones in which Executive is a passive investor. Executive may engage in civic and
not-for-profit activities so long as such activities do not materially interfere with the performance of Executive’s duties hereunder. Executive may also serve on the Board of Directors of one (1) for-profit company (and be compensated in
equity and cash for such service), provided such company is determined by the Board to not be directly competitive with the Company. 

8.2  No Adverse Interests.  Executive agrees not to acquire, assume or participate in, directly or
indirectly, any position, investment or interest known to be materially adverse to the Company, its business or prospects, financial or otherwise. 

9. Non-Solicitation.  Executive agree that during the period of employment with the Company and for twelve
(12) months after the date Executive’s employment is terminated for any reason, Executive will not, either directly or through others, solicit or encourage or attempt to solicit or encourage any employee, independent contractor, or
consultant of the Company to terminate his or her relationship with the Company in order to become an employee, consultant or independent contractor to or for any other person or entity. 

10. Dispute Resolution.  To ensure the timely and economical resolution of disputes that may arise in
connection with Executive’s employment with the Company, Executive and the Company agree that any and all disputes, claims, or causes of action arising from or relating to the enforcement, breach, performance, negotiation, execution, or
interpretation of this Agreement, Executive’s employment, or the termination of Executive’s employment, including but not limited to statutory claims, shall be 

  

 
resolved to the fullest extent permitted by law by final, binding and confidential arbitration, by a single arbitrator, in Santa Clara County, California, conducted by JAMS, Inc.
(“JAMS”) under the then applicable JAMS rules. By agreeing to this arbitration procedure, both Executive and the Company waive the right to resolve any such dispute through a trial by jury or judge or administrative
proceeding. The Company acknowledges that Executive will have the right to be represented by legal counsel at any arbitration proceeding. The arbitrator shall: (a) have the authority to compel adequate discovery for the resolution of the
dispute and to award such relief as would otherwise be permitted by law; and (b) issue a written arbitration decision, to include the arbitrator’s essential findings and conclusions and a statement of the award. The arbitrator shall be
authorized to award any or all remedies that Executive or the Company would be entitled to seek in a court of law. The Company shall pay all JAMS’ arbitration fees in excess of the amount of court fees that would be required of the Executive if
the dispute were decided in a court of law. Nothing in this Agreement is intended to prevent either Executive or the Company from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion of any such arbitration. Any
awards or orders in such arbitrations may be entered and enforced as judgments in the federal and state courts of any competent jurisdiction. 

11. General Provisions. 

11.1  Notices.  Any notices provided must be in writing and will be deemed effective upon
the earlier of personal delivery (including personal delivery by fax or email) or the next day after sending by overnight carrier, to the Company at its primary office location, fax number or email address of an officer or Chairman of the Board of
the Company, and to Executive at the address, fax number or personal email address as listed on the Company payroll or HR records. 

11.2  Severability.  Whenever possible, each provision of this Agreement will be
interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any applicable law or rule in any jurisdiction, such
invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction to the extent possible in keeping with the intent of the
parties. 
 11.3  Waiver.  Any waiver of any breach of any provisions of this Agreement
must be in writing to be effective, and it shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 

11.4  Complete Agreement.  This Agreement, together with the Confidentiality Agreement and
Option Agreement, constitutes the entire agreement between Executive and the Company with regard to this subject matter and is the complete, final, and exclusive embodiment of the Parties’ agreement with regard to this subject matter. This
Agreement is entered into without reliance on any promise or representation, written or oral, other than those expressly contained herein, and it supersedes any other such promises, warranties or representations. It is entered into without reliance
on any promise or representation other than those expressly 

  

 
contained herein, and it cannot be modified or amended except in a writing signed by a duly authorized officer of the Company. 

11.5  Counterparts.  This Agreement may be executed in separate counterparts, any one of which
need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 

11.6  Headings.  The headings of the paragraphs hereof are inserted for convenience only and shall
not be deemed to constitute a part hereof nor to affect the meaning thereof. 
 11.7  Successors and
Assigns.  This Agreement is intended to bind and inure to the benefit of and be enforceable by Executive and the Company, and their respective successors, assigns, heirs, executors and administrators, except that Executive may
not assign any of his duties hereunder and he may not assign any of his rights hereunder without the written consent of the Company, which shall not be withheld unreasonably. 

11.8  Tax Withholding and Indemnification.  All payments and awards contemplated or made pursuant
to this Agreement will be subject to withholdings of applicable taxes in compliance with all relevant laws and regulations of all appropriate government authorities. Executive acknowledges and agrees that the Company has neither made any assurances
nor any guarantees concerning the tax treatment of any payments or awards contemplated by or made pursuant to this Agreement. Executive has had the opportunity to retain a tax and financial advisor and fully understands the tax and economic
consequences of all payments and awards made pursuant to the Agreement. 
 11.9  Choice of
Law.  All questions concerning the construction, validity and interpretation of this Agreement will be governed by the laws of the State of California. 

IN WITNESS WHEREOF, the Parties have executed this
Agreement on the day and year written below. 
  

									
		 		 	 CARBYLAN BIOSURGERY, INC.

				
		 		 	 By:
	 	 /s/ Albert Cha

		 		 		 		 	 Albert Cha, Director

				
		 		 	 Date:
	 	 May 30, 2013

		 	 EXECUTIVE
	 		 		 	
				
		 	 David Renzi
	 		 	 /s/ David Renzi

				
		 		 	 Date:
	 	 May 30, 2013EX-10.8

 Exhibit 10.8 
  

 
 June 26, 2014 

Mr. Thomas Michael White 
 [Home Address] 

 
 Re:  Employment Agreement 

 
  
 Dear Michael: 

 
 We are pleased to extend you this offer of employment with Carbylan Therapeutics, Inc. (the
“Company”), contingent upon the conditions outlined in Section 8 below. This letter (the “Agreement”) contains the terms of our employment offer. 

 

	1.	 Position. 

  

	 	a.	 You will fill the position of Vice President of Finance and Chief Financial Officer, with an assigned work location of the Company’s corporate
headquarters. You will report to the Company’s President and Chief Executive Officer. This is a full-time position, and you agree to the best of your ability and experience that you will at all times loyally and conscientiously perform all of
the duties and obligations required of and from you pursuant to the express and implicit terms hereof, and to the satisfaction of the Company. During the term of your employment, you further agree that you will devote your full business time and
best professional efforts exclusively to the performance of your duties and responsibilities for the Company, and you will not directly or indirectly engage or participate in any business that is competitive in any manner with the business of the
Company. The Company retains the discretion to modify your position, duties, reporting relationship, and work location from time to time. 

  

	 	b.	 Subject to your fulfillment of the conditions outlined in Section 8 below, your employment with the Company will commence on July 7, 2014 (your
“Start Date”), or on such other date as mutually agreed by you and the Company. 

  

	2.	 Proof of Right to Work. 

  

	 	a.	 To comply with the Immigration Reform and Control Act, you will be required to provide to the

 

 
  

	 	 
Company documentary evidence of your identity and eligibility for employment in the United States. Such documentation must be provided within three business days of your date of hire, or the
Company will not be able to employ you. 

  

	3.	 Compensation. 

  

	 	a.	 Base Salary. You will be paid a base salary at the annual rate of $275,000, subject to payroll withholdings and deductions. Your base salary will be
paid in two equal payments per month in accordance with the Company’s regular payroll practices. As an exempt salaried employee, you will be expected to work the Company’s standard business hours, and such additional hours as required by
the nature of your work assignments and job responsibilities, and you will not be eligible for overtime compensation. The Company retains the discretion to modify your compensation terms (including the bonus program) from time to time.

  

	 	b.	 Bonus. You will be eligible for consideration by the Company’s Board of Directors (the “Board”) for an annual bonus of up to
twenty-five percent (25%) of your annual base salary, with the bonus determination to be made by the Board within its sole discretion. Payment of the bonus will be based on the level of achievement of the applicable objectives and milestones,
as such objectives and milestones are set by the Board in its sole discretion, and as such achievement is evaluated by the Board in its sole discretion, and the bonus is not guaranteed. As a condition precedent to earning and receiving any bonus,
you must remain an active employee with the Company through the date the bonus otherwise is scheduled to be paid; and if your employment has been terminated for any reason, regardless of whether the termination is by you or the Company, you will not
earn or be entitled to receive any bonus which has not been paid prior to the termination date. 

  

	4.	 Stock Options. 

In connection with the commencement of your employment, the Company will recommend that the Company’s Board of Directors grant you
an option to purchase 422,026 shares of the Company’s Common Stock (“Option Shares”) with an exercise price equal to the fair market value on the date of the grant. One quarter (12/48) of these option shares will vest on the
12-month anniversary of your Vesting Commencement Date (as defined in your Stock Option Agreement, which date will be your Start Date, as defined above) and the remaining Option Shares will vest one-forty-eighth (1/48) per month thereafter
until all such remaining Option Shares have become fully vested (approximately four years from your Start Date). Vesting will, of course, depend on your continued employment with the Company. The option will be subject to the terms of the
Company’s 2004 Stock Plan and a stock option agreement between you and the Company in the form reasonably determined by the Company. 
  

	5.	 Benefits. 

  

	 	a.	 Insurance Benefits. You will be eligible to participate in the Company’s standard medical and dental

 

 
  

	 	 
insurance benefits, subject to the terms and conditions of these benefit plans, as in effect from time to time. 

 

	 	b.	 Paid Time Off. You will be eligible to accrue paid vacation, and be eligible for paid sick time and paid holidays, under the terms of the
Company’s applicable policies, as in effect from time to time. 

 You will be eligible to participate in any
other benefits offered by the Company generally to its employees from time to time, subject to the terms and conditions of these benefit plans and the Company’s policies, as in effect from time to time. The Company reserves the right to add to,
change, or terminate any or all of its benefit programs and related policies in its sole discretion. 
  

	6.	 Compliance with Company Policies and Confidential Information and Invention Assignment Agreement. 

As a condition of your employment with the Company, you will be required to abide by the Company’s policies and procedures,
including but not limited to the policies contained in the Company’s Employee Handbook, as may be in effect from time to time. In addition, your acceptance of this offer and commencement of employment with the Company is contingent upon your
execution and delivery to an officer of the Company the Company’s Employee Proprietary Information and Invention Agreement, a copy of which is enclosed for your review and execution (the “Confidentiality Agreement”), on
or prior to your Start Date. 
  

	7.	 Prior Confidentiality Obligations. 

In your work for the Company, you will be expected not to use or disclose any confidential information, including trade secrets, of any
former employer or other person to whom you have an obligation of confidentiality. Rather, you will be expected to use only that information which is generally known and used by persons with training and experience comparable to your own, which is
common knowledge in the industry or otherwise legally in the public domain, or which is otherwise provided or developed by the Company. You agree that you will not bring onto Company premises, any unpublished documents or property belonging to any
former employer or other person to whom you have an obligation of confidentiality. You hereby represent that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company. 

 

	8.	 Conditional Offer. 

This offer is contingent upon: 
  

	 	a.	 your producing documents required under the Immigration Reform and Control Act verifying your identity and eligibility for employment in the United States as
outlined in Section 3 above; 

  

	 	b.	 [favorable pre-employment reference checks, criminal background check, education verification, and drug screening results (with necessary services to be
provided by and at the Company’s cost);] and 

 

 
  

	 	c.	 your execution of the Confidentiality Agreement, as well as other necessary employment documents that will be provided to you. 

 

	9.	 At-Will Employment. 

Your employment with the Company will be on an “at will” basis, meaning that either you or the Company may terminate your
employment at any time, with or without cause, and with or without advance notice. In addition, the Company may also change any term or condition of your employment with or without cause. This “at will” relationship can only be changed by
an agreement in writing signed by an expressly authorized officer of the Company. 
  

	10.	 Severance Benefits for Qualifying Terminations. 

  

	 	a.	 General Severance Benefits. You shall be entitled to receive the General Severance Benefits (as defined below), as your sole severance benefits, if
your employment is terminated by the Company without Cause (as defined below) and if: (i) such termination of employment is not due to your death or disability; (ii) your termination constitutes a “separation from service” (as
defined under Treasury Regulation Section 1.409A-1(h)); and (iii) within the timing required by the Company, you sign, date and return to the Company a general release of all known and unknown claims (the “Release”)
substantially in the form attached hereto as Exhibit A, and such Release becomes effective in accordance with its terms, including through the expiration of any applicable revocation period. 

For purposes of this Section 10(a), the “General Severance Benefits” shall consist of the following:
(i) continued payment of your final base monthly salary for a period of six (6) months following the termination date; (ii) accelerated vesting of any outstanding stock options such that the additional number of shares that would have
vested if your employment had continued for six (6) additional months following the termination date will become vested and exercisable effective as of the termination date; and (iii) if you timely elect continued group health insurance
coverage pursuant to federal COBRA law or, if applicable, state insurance laws (collectively, “COBRA”), the Company will pay your COBRA premiums to continue your group health insurance coverage (including the cost of dependent
coverage) through the earliest of (A) six (6) months following the termination date, (B) the date that you become eligible for group health insurance coverage through a new employer, or (C) the date you cease to be eligible for
COBRA coverage. Notwithstanding the foregoing, the General Severance Benefits will immediately expire in the event that you obtain new full-time employment (or full-time consulting or similar arrangement) within six (6) months after the
termination date, provided, however, that the Company will thereafter continue to pay you, through the six-month severance payment period, the excess, if any, of your Company base salary on the date of termination over the base salary for
your new employment relationship. You agree to notify the Company of your acceptance of any employment within the six-month severance payment period. In the event of your death during the six (6) month severance period, the remaining General

 

 
  

 
Severance Benefits shall be paid to your estate. Any severance payments made under this Agreement will be made in the form of salary continuation, and will begin on the next regular Company
payday which is at least five (5) business days following the later of the effective date of the Release or the date on which the Release, signed by you, is received by the Company. The first payment, however, will be retroactive to the next
business day following the termination date. 
  

	 	b.	 Change of Control Severance Benefits. You shall be entitled to receive the Change of Control Severance Benefits (as defined below), as your sole
severance benefits, if, on or within twelve (12) months after a Change of Control (as defined below), your employment is terminated by the Company without Cause or you terminate your employment for Good Reason (as defined below) and if;
(i) such termination of employment is not due to your death or disability; (ii) your termination constitutes a “separation from service” (as defined under Treasury Regulation Section 1.609A-1(h)); and (iii) within the
timing required by the Company, you sign, date and return to the Company the Release substantially in the form attached hereto as Exhibit A, and such Release becomes effective in accordance with its terms, including through the
expiration of any applicable revocation period. 

 For the purposes of Section 10(b), the “Change of
Control Severance Benefits” shall consist of the following: (i) you shall receive the General Severance Benefits as provided above, except that the continued salary payments will not be terminated or reduced in the event that you
obtain new employment during the six-month severance payment period; (ii) you will also be eligible to receive a prorated bonus payment for the year in which your employment terminates (notwithstanding that you otherwise would not be eligible
for payment of such bonus due to termination of employment prior to the bonus payment date), with such prorated bonus amount to be based on the achievement of the bonus objectives prior to such termination or resignation (provided that, no prorated
bonus will be owed if the Board determines that there has been no achievement of such bonus objectives), and (iii) you will be eligible for the Full Acceleration as provided in Section 11 hereof. 

 

	 	c.	 For purposes of this Agreement, “Cause” for termination of employment shall mean: (i) your failure to substantially perform the
principal duties and obligations of your position with the Company; (ii) any act of personal dishonesty, fraud or misrepresentation by you which was intended to or does result in your substantial gain or personal enrichment at the expense of
the Company; (iii) your violation of a federal or state law or regulation applicable to the Company’s business or any of the Company’s policies, which violation was or is reasonably likely to be injurious to the Company or its
business or reputation; (iv) your conviction of a felony or a plea of nolo contendere under the laws of the United States or any State; or (v) your material breach of the terms of any agreement or contract between you and the Company. The
determination that a termination is for Cause shall be made in good faith by the Board in its sole discretion. 

 

 
  

	 	d.	 You may voluntarily terminate your employment for “Good Reason” under Section 10(b) of this Agreement by notifying the Company in
writing, within thirty (30) days after the first occurrence of one of the following events taken without your consent, that you intend to terminate your employment for Good Reason on a date not later than the ninetieth (90th) day following such event, if the Company has not cured that event within thirty (30) days after its receipt of your written notice. The events that may give rise to a Good Reason
termination are: (i) a material and substantial reduction in the scope of your duties and responsibilities (provided, however, that a change in job position (including a change in title) shall not be deemed a “material reduction”
unless your new duties are substantially reduced from your prior duties); (ii) relocation of your principal office that results in a one-way increase in your commute distance of more than 30 miles; or (iii) a reduction in your base salary
by more than twenty (20%) percent (provided that an across-the-board reduction in the salary level of all Vice Presidents of the Company by the same (or a greater) percentage amount shall not constitute Good Reason). 

 

	11.	 Change of Control. 

For purposes of this Agreement, “Change of Control” shall mean the consummation of a transaction or series of
transactions that results in: (i) any sale or other disposition of all or substantially all of the assets of the Company. that occurs over a period of not more than twelve (12) months; or (ii) any person, or more than one person
acting as a group, acquiring ownership of stock of the Company, that together with the stock held by such person or group, constitutes more than fifty percent (50%) of the total fair market value or total voting power of the stock of such
corporation. However, a Change of Control shall not include (x) any consolidation or merger effected exclusively to change the domicile of the Company, or (y) any transaction or series of transactions principally for bona fide equity
financing purposes in which cash is received by the Company or any successor or indebtedness of the Company is cancelled or converted or a combination thereof. This definition of Change of Control is intended to conform to the definitions of
“change in ownership of a corporation” and “change in ownership of a substantial portion of a corporations assets” provided in Treasury Regulation Sections 1.409A-3(i)(5)(v) and (vii). 

In the event that, on or within twelve (12) months after the consummation of a Change of Control of the Company, your employment
with the Company (or its successor, as applicable) is terminated by the Company (or its successor, as applicable) without Cause or you terminate your employment for Good Reason, 100% of the shares subject to any outstanding stock options held by you
will be immediately vested and exercisable in full effect as of the employment termination date (the “Full Acceleration”). Notwithstanding the foregoing, as a pre-condition of the Full Acceleration, within the timing required by the
Company, you must sign, date and return to the Company the Release substantially in the form attached hereto as Exhibit A, and such Release becomes effective in accordance with its terms, including through the expiration of any
applicable revocation period. 
  

	12.	 Deferred Compensation.  

 

 
  

 It is intended that (i) each installment of any amounts or benefits payable under
Section 10 of this Agreement be regarded as a separate “payment” for purposes of Treasury Regulations Section 1.409A-2(b)(2)(i) (and each such installment is hereby designated as separate for such purpose), (ii) all payments
of any such amounts or benefits satisfy, to the greatest extent possible, the exemptions from the application of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations and other guidance
thereunder and any state law of similar effect (collectively “Section 409A”), as provided under Treasury Regulations Sections 1.409A-1(b)(4) and 1.409A-1(b)(9)(iii); and (iii) any such amounts or benefits consisting of premiums
payable under COBRA also satisfy, to the greatest extent possible, the exemption from the application of Section 409A provided under Treasury Regulations Section 1.409A-1(b)(9)(v). However, if any such amounts or benefits constitute
“deferred compensation” under Section 409A and if you are a “specified employee” of the Company, as such term is defined in Section 409A(a)(2)(B)(i), then, solely to the extent necessary to avoid the imposition of the
adverse personal tax consequences under Section 409A, the timing of any such benefit payments as to which you are entitled shall be delayed as follows: on the earlier to occur of (a) the date that is six (6) months and one
(1) day after your separation from service and (b) the date of your death (such applicable date, the “Delayed Initial Payment Date”), the Company shall (1) pay you a lump sum amount equal to the sum of the benefit
payments that you would otherwise have received through the Delayed Initial Payment Date if the commencement of the payment of the benefits had not been delayed pursuant to this Section 12 and (2) commence paying the balance, if any, of
the benefits in accordance with the applicable payment schedule. 
 This Agreement, together with the Confidentiality Agreement, sets for the entire
agreement and understanding between you and the Company relating to your employment and supersedes all prior agreements, understandings and discussions between you and the Company. This letter may not be modified or amended except by a written
agreement, signed by the Chief Executive Officer of the Company, although the Company reserves the right to modify unilaterally your compensation, benefits, job title and duties, reporting relationships and other terms of your employment. 

Michael, we are pleased to offer you these employment terms and would appreciate your acceptance by signing and returning this document to me no later
than the end of day Monday June 30, 2014. 
  

	
	Sincerely,
	
	 /s/ David M. Renzi

	 David M. Renzi

	 President and CEO

 

 
  

 UNDERSTOOD, ACCEPTED AND AGREED: 

T. Michael White 
  

	
	 /s/ Michael White

	 Signature

	
	 6/27/2014

	 Date

 

 
  

 EXHIBIT A 

RELEASE AGREEMENT 
 In
exchange for the General Severance Benefits, the Change of Control Severance Benefits, and/or the Full Acceleration, as applicable, to be provided to me pursuant to the Employment Agreement dated June 27, 2014 (the “Agreement”)
between me and Carbylan Therapeutics, Inc. (the “Company”), I hereby provide the following release of claims (the “Release”). 

In exchange for the severance pay and benefits provided to me under the Agreement, to which I acknowledge I would not otherwise be
entitled, and for other good and valuable consideration, the receipt and sufficiency of which I hereby acknowledge, I hereby generally and completely release the Company, its parent and subsidiary entities, and their respective directors, officers,
employees, shareholders, stockholders, partners, agents, attorneys, predecessors, successors, insurers, employee benefit plans, affiliates, and assigns (collectively, the “Released Parties”) of and from any and all claims,
liabilities and obligations, both known and unknown, arising out of or in any way related to events, acts, conduct, or omissions occurring at any time prior to or at the time that I sign this Release (collectively, the “Released
Claims”). The Released Claims include, but are not limited to: (1) all claims arising out of or in any way related to my employment with the Company (or its successor) or the termination of that employment; (2) all claims related
to my compensation or benefits, including salary, bonuses, commissions, vacation pay, expense reimbursements, severance pay, fringe benefits, stock, stock options, or any other ownership or equity interests in the Company; (3) all claims for
breach of contract, wrongful termination, and breach of the implied covenant of good faith and fair dealing (including, but not limited to, any claims based on or arising from the Agreement); (4) all tort claims, including claims for fraud,
defamation, emotional distress, and discharge in violation of public policy; and (5) all federal, state, and local statutory claims, including claims for discrimination, harassment, retaliation, attorneys’ fees, or other claims arising
under the federal Civil Rights Act of 1964 (as amended), the federal Americans with Disabilities Act of 1990, the federal Age Discrimination in Employment Act (as amended) (“ADEA”), the federal Family and Medical Leave Act (as
amended) (“FMLA”), the California Family Rights Act (“CFRA”), the California Labor Code (as amended), and the California Fair Employment and Housing Act (as amended). 

Notwithstanding the foregoing, the following are not included in the Released Claims (the “Excluded Claims”):
(1) any rights or claims for indemnification I may have pursuant to any written indemnification agreement with the Company to which I am a party, the charter, bylaws, or operating agreements of the Company, applicable law, or applicable
directors and officers liability insurance; (2) any rights or claims which are not waivable as a matter of law; and (3) any claims for breach of the Agreement arising after the date that I sign this Release. In addition, nothing in this
Release prevents me from filing, cooperating with, or participating in any proceeding before the Equal Employment Opportunity Commission, the Department of Labor, the California Department of Fair Employment and Housing, or any other government
agency, except that I acknowledge and agree that I am hereby waiving my right to any monetary benefits in connection with any such claim, charge or proceeding. I represent that I have no lawsuits, claims or actions pending in my name, or on behalf
of any other person or entity, against any of the Released Parties. 

 

 
  

 The following paragraph shall apply to me only if I am forty (40) years old
or older as of the date that I sign this Release: I acknowledge that I am knowingly and voluntarily waiving and releasing any rights I may have under the ADEA, and that the consideration given for the waiver and release in the preceding
paragraph is in addition to anything of value to which I am already entitled. I further acknowledge that I have been advised by this writing that: (1) my waiver and release do not apply to any rights or claims that may arise after the date I
sign this Release; (2) I have been advised to consult with an attorney prior to signing this Release (although I may choose voluntarily not to do so) and I have had sufficient opportunity to do so; (3) I have twenty-one (21) days to
consider this Release (although I may choose voluntarily to sign it earlier); (4) I have seven (7) days following the date I sign this Release to revoke it by providing written notice of revocation to the Company’s Board of Directors;
and (5) this Release will not be effective until the date upon which the revocation period has expired, which will be the eighth calendar day after the date I sign it if I do not revoke it (such date, the “Effective Date”).

 The following paragraph shall apply to me only if I am less than forty (40) years old as of the date that I sign this
Release: I understand that I have fourteen (14) days to consider this Release (although I may choose voluntarily to sign it earlier), the Release will become effective as of the date that I sign it (such date, the “Effective
Date”), and I do not have the right to revoke this Release after signing it. 
 I UNDERSTAND THAT THIS RELEASE AGREEMENT
INCLUDES A RELEASE OF ALL KNOWN AND UNKNOWN CLAIMS. I acknowledge that I have read and understand Section 1542 of the California Civil Code which reads as follows: “A general release does not extend to claims which the creditor does not
know or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor.” I hereby expressly waive and relinquish all rights and
benefits under that section and any law or legal principle of similar effect in any jurisdiction with respect to my release of claims herein, including but not limited to the release of unknown and unsuspected claims. 

I hereby represent that I have been paid all compensation owed and for all time worked, I have received all the leave and leave benefits
and protections for which I am eligible, pursuant to FMLA, CFRA, any Company policy or applicable law, and I have not suffered any on-the-job injury or illness for which I have not already filed a workers’ compensation claim. 

I further agree: (1) not to disparage the Company, or any of the other Released Parties, in any manner likely to be harmful to its
or their business, business reputation, or personal reputation (although I may respond accurately and fully to any question, inquiry or request for information as required by legal process); (2) not to voluntarily (except in response to legal
compulsion) assist any third party in bringing or pursuing any proposed or pending litigation, arbitration, administrative claim or other formal proceeding against the Company, its parent or subsidiary entities, affiliates, officers, directors,
employees or agents; and (3) to cooperate fully with the Company, by voluntarily (without legal compulsion) providing accurate and complete information, in connection with the Company’s actual or contemplated defense, prosecution, or
investigation of any claims or demands by or against third parties, or other matters, arising from events, acts, or failures to act that occurred during the period of my employment by the Company or any successor thereto. 

 

 
  

 I understand that, upon the Effective Date, this Release will take effect as a legally
binding agreement between me and the Company. This Release sets for the entire agreement and understanding between the Company and me relating to the matters set forth herein and supersedes all prior and contemporaneous agreements, understandings
and discussions concerning such matters, whether express or implied. This Release may not be modified or amended except by a written agreement, signed by the Chief Executive Officer of the Company and me. 

 

			
	By:	 	/s/ Michael White
		 	[Name]

 
			
		 	
	Date:	 	 6/27/14

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