Document:

EX-10.57

 Exhibit 10.57 
 Quintiles Transnational Holdings Inc. 
 Annual Management Incentive Plan

  

	1.	Purpose of the Plan 

 The
purpose of the Plan is to enable the Company and its Affiliates to attract, retain, motivate and reward executive officers and members of senior management by providing them with the opportunity to earn competitive compensation directly linked to
the Company’s performance. The Plan is intended to be exempt from Section 162(m) of the Code (as hereinafter defined) until the first shareholder meeting occurring after the close of the third calendar year following the calendar year in
which the Company becomes publicly held. 
  

	2.	Definitions 

 The
following capitalized terms used in the Plan have the respective meanings set forth in this Section: 
  

	 	(a)	“Administrator” shall mean the Compensation and Nominations Committee of the Board or a subcommittee thereof or any successor thereto, or any other committee
designated by the Board to act as the Administrator under the Plan. 

  

	 	(b)	“Affiliate” shall mean, with respect to the Company, any entity directly or indirectly controlling, controlled by, or under common control with, the Company
or any other entity designated by the Board in which the Company or an Affiliate has an interest. 

  

	 	(c)	“Award” shall mean, with respect to each Participant, the award determined pursuant to Section 4 below for a Performance Period.

  

	 	(d)	“Board” shall mean the Board of Directors of the Company. 

  

	 	(e)	“Business Performance Factor” shall mean that factor attributable to the Company’s achievement of one or more Performance Goals, which may be used to
calculate a Participant’s Award. 

  

	 	(f)	“Code” shall mean the Internal Revenue Code of 1986, as amended from time to time. 

 

	 	(g)	“Company” shall mean Quintiles Holdings Transnational Inc. 

  

	 	(h)	“Individual Performance Factor” shall mean that factor attributable to a Participant’s individual achievement of one or more Performance Goals, which may
be used to calculate a Participant’s Award. 

  

	 	(i)	“Participant” shall mean each executive officer of the Company and any other member of senior management of the Company or an Affiliate whom the Administrator
designates as a participant under the Plan. 

	 	(j)	“Payout Formula” shall mean, as to any Performance Period, the formula or payout matrix established by the Administrator pursuant to Section 4 in order
to determine the Awards (if any) to be paid to Participants. The formula or matrix may differ from Participant to Participant, and may include a Business Performance Factor and an Individual Performance Factor. 

 

	 	(k)	“Performance Goals” shall mean performance goals based on criteria as determined by the Administrator in the Administrator’s sole discretion. To the
extent attributable to individual achievement, such criteria may vary from Performance Period to Performance Period and from one Participant to another and may be given different weightings, but they will generally relate to operational improvements
that are within the individual Participant’s area of responsibility, the Company’s strategic goals and enhancement of the Participant’s leadership and management skills. These objectives will typically be qualitative objectives, and
the Administrator shall apply its business judgment in assessing the extent to which the individual Participants met their objectives. To the extent attributable to Company achievement, such criteria may include one or more of the following as the
Administrator shall determine: 

  

	 	(1)	Net earnings or net income (before or after taxes); 

  

	 	(2)	Earnings per share; 

  

	 	(3)	Net new business; 

  

	 	(4)	Net sales or revenue growth; 

  

	 	(5)	Net operating profit (including, but not limited to, operating income and operating surplus); 

 

	 	(6)	Return measures (including, but not limited to, return on assets, capital, invested capital, equity, sales, or revenue); 

 

	 	(7)	Cash flow (including, but not limited to, operating cash flow, free cash flow, cash generation, cash flow return on equity, and cash flow return on investment);

  

	 	(8)	Earnings before or after taxes, interest, depreciation, and/or amortization; 

 

	 	(9)	Gross, contribution, or operating margins; 

  

	 	(10)	Share price (including, but not limited to, growth measures and total shareholder return); 

 

	 	(11)	Expense targets; 

  

	 	(12)	Operating efficiency (including, but not limited to, productivity measurements); 

 

	 	(13)	Market share; 

  

	 	(14)	Working capital targets and change in working capital; 

  

	 	(15)	 Economic value added or
EVA® (net operating profit after tax minus the sum of capital multiplied by the cost of capital) ; and

  

	 	(16)	Segment income from operations and income from operations. 

 The foregoing criteria may relate to the Company, one or more of its Subsidiaries or one or more of its divisions or units, or any combination of the foregoing, and may be applied on an absolute basis
and/or be relative to one or more peer group companies or indices, or any combination thereof, all as the Administrator shall determine. The foregoing criteria may also vary from Performance Period to Performance Period and from Participant to
Participant and have different weightings. The Administrator 

  
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shall have the authority to make equitable adjustments to the Performance Goals in recognition of unusual or non-recurring events affecting the Company or any Affiliate thereof or the financial
statements of the Company or any Affiliate thereof, in response to changes in applicable laws or regulations, or to account for items of gain, loss or expense determined to be extraordinary or unusual in nature or infrequent in occurrence or related
to the disposal of a segment of a business or related to a change in accounting procedures. These adjustments may also include the following: restructuring costs, impairment charges, transaction expenses, share based compensation and cash bonus
expenses, operating income and transaction costs associated with acquisitions, and the impact of foreign currency fluctuations. 
  

	 	(l)	“Performance Period” shall mean each fiscal year of the Company or shorter period if determined by the Administrator; the initial Performance Period shall be
fiscal year 2013. 

  

	 	(m)	“Person” shall mean a “person,” as such term is used for purposes of Section 13(d) or 14(d) of the Securities Exchange Act of 1934, as amended
(or any successor section thereto). 

  

	 	(n)	“Plan” shall mean the Quintiles Transnational Corp. Annual Management Incentive Plan as set forth herein and as may be amended from time to time.

  

	 	(o)	“Subsidiary” shall mean a subsidiary corporation, as defined in Section 424(f) of the Code (or any successor section thereto). 

 

	 	(p)	“Target Award” shall mean, with respect to any Participant, their target annual bonus opportunity with respect to a Performance Period expressed as a
percentage of their base salary or a specific dollar amount or as determined by the Administrator in accordance with Section 4(b). 

  

	3.	Administration 

 The Plan
shall be administered and interpreted by the Administrator. The Administrator shall have such powers as may be necessary to discharge its duties hereunder, including but not limited to the discretionary authority (i) to establish Performance
Goals, Payout Formulae and Target Awards for any Performance Period and certify whether and to what extent such Performance Goals have been satisfied in accordance with Section 4, (ii) to determine eligibility and the amount, manner and
time of payment of any Awards hereunder and (iii) to construe and interpret the terms of the Plan. Any determination made by the Administrator under the Plan shall be final and conclusive. The Administrator may employ such legal counsel,
consultants and agents (including counsel or agents who are employees of the Company or an Affiliate) as it may deem desirable for the administration of the Plan and may rely upon any opinion received from any such counsel or consultant or agent and
any computation received from such consultant or agent. All expenses incurred in the administration of the Plan, including, without limitation, for the engagement of any counsel, consultant or agent, shall be paid by the Company. No member or former
member of the Board or the Administrator shall be liable for any act, omission, 

  
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interpretation, construction or determination made in connection with the Plan other than as a result of such individual’s willful misconduct. 

 

	4.	Bonuses 

 (a)
Performance Goals and Payout Formula. In the beginning of each Performance Period (and generally within the first 90 days of each fiscal year, or the first 25 percent of the Performance Period if the Performance Period is shorter than a
year), the Administrator shall establish the Performance Goals and Payout Formula with respect to the applicable Performance Period. The Performance Goals and Payout Formula established by the Administrator and the Administrator’s
determinations and interpretations with respect thereto need not be the same with respect to each Participant (whether or not the Participants are similarly situated.) 
 (b) Target Awards. In the beginning of each Performance Period (and generally within the first 90 days of each fiscal year, or the first 25 percent of the Performance Period if the Performance
Period is shorter than a year), the Administrator shall establish the Target Award for each Participant with respect to the applicable Performance Period. 
 (c) Maximum Amount Payable. As soon as practicable after a Performance Period ends, the Administrator shall determine (i) whether and to what extent any of the Performance Goals established
for the relevant Performance Period under Section 4(a) have been satisfied, and (ii) for each eligible Participant, the actual Award to which such Participant shall be entitled, taking into consideration the extent to which the Performance
Goals have been met and such other factors as the Administrator may deem appropriate. Any provision of this Plan notwithstanding, in no event shall any Participant receive an Award under this Plan in respect of any fiscal year of the Company in
excess of six million dollars ($6,000,000). 
 (d) Negative Discretion/Waiver. Notwithstanding anything else contained in
Section 4 to the contrary, the Administrator shall have the right, in its absolute discretion, (i) to reduce or eliminate the amount otherwise payable to any Participant under Section 4(c) based on individual performance or any other
factors that the Administrator, in its discretion, shall deem appropriate, (ii) to establish rules or procedures in the beginning of each Performance Period (and generally within the first 90 days of each fiscal year) that have the effect of
limiting the amount payable to each Participant to an amount that is less than the maximum amount otherwise authorized under Section 4(c), and (iii) to waive any applicable Performance Goals for any Participant or group of Participants
under the Plan and pay the amount that would otherwise have become payable had the applicable Performance Goals been achieved, in whole or in part. 
 (e) Termination of Employment. Unless otherwise determined by the Administrator or as specified in the Participant’s employment agreement with the Company or any of its Affiliates, a
Participant shall not be entitled to the payment of any bonuses hereunder with respect to a Performance Period in the event of the termination of the Participant’s employment with the Company and its Affiliates for any reason prior to the date
Awards are to be paid. 
  

	5.	Payment 

 (a) In
General. Except as otherwise provided hereunder, payment of any Award determined under Section 4 shall be made to each Participant as soon as practicable after the 

  
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Administrator certifies that one or more of the applicable Performance Goals have been attained or, in the case of any bonus payable under the provisions of Section 4(d), after the
Administrator determines the amount of any such bonus; but in any event, no later than two and one-half months (2  1/2 months) following the end of the Performance Period to which such bonus relates. Awards under the Plan are
intended to qualify for exemption from, or to comply with the requirements of, Section 409A, and the Plan will be interpreted in a manner consistent with such intent. 

(b) Form of Payment. All bonuses hereunder shall be paid in cash or such other form (including shares of the Company’s common
stock or stock units) as the Administrator may determine in its discretion. To the extent the bonuses hereunder are paid in shares of the Company’s common stock or stock units, such shares or units will be issued pursuant to the Company’s
2013 Stock Incentive Plan or other appropriate equity compensation plan in effect at such time and be subject to the terms and conditions thereof. 
 (c) Recoupment. A Participant will be obligated to return to the Company payments received with respect to Awards in the event of an overpayment to the Participant of incentive compensation due to
inaccurate financial data, in accordance with any applicable Company clawback or recoupment policy, as such policy may be amended and in effect from time to time, or as otherwise required by law or applicable stock exchange listing standards,
including, without limitation Section 10D of the Securities Exchange Act of 1934, as amended. Each Participant, by accepting an Award pursuant to the Plan, agrees to return the full amount required under this Section 5(c) at such time and
in such manner as the Administrator shall determine in its sole discretion and consistent with applicable law. 
  

	6.	General Provisions 

 (a)
Effectiveness of the Plan. The Plan shall be effective as of January 1, 2013 (the “Effective Date”). The Plan shall expire on the tenth anniversary of the Effective Date. 

(b) Amendment and Termination. The Board or the Administrator may at any time amend, suspend, discontinue or terminate the Plan.

 (c) No Right to Continued Employment or Awards. Nothing in this Plan shall be construed as conferring upon any
Participant any right to continue in the employment of the Company or any of its Affiliates. There is no obligation for uniformity of treatment of Participants or beneficiaries. The terms and conditions of awards and the Administrator’s
determinations and interpretations with respect thereto need not be the same with respect to each Participant (whether or not the Participants are similarly situated). 
 (d) No Limitation on Corporate Actions. Nothing contained in the Plan shall be construed to prevent the Company or any Affiliate from taking any corporate action which is deemed by it to be
appropriate or in its best interest, whether or not such action would have an adverse effect on any awards made under the Plan. No employee, beneficiary or other person shall have any claim against the Company or any Affiliate as a result of any
such action. 
 (e) Nonalienation of Benefits. Except as expressly provided herein, no Participant or beneficiary shall
have the power or right to transfer, anticipate, or otherwise encumber the 

  
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Participant’s interest under the Plan. The Company’s obligations under this Plan are not assignable or transferable except to (i) a corporation which acquires all or substantially
all of the Company’s assets, or (ii) any corporation into which the Company may be merged or consolidated. The provisions of the Plan shall inure to the benefit of each Participant and the Participant’s beneficiaries, heirs,
executors, administrators or successors in interest. 
 (f) Withholding. A Participant may be required to pay to the
Company or any Affiliate and the Company or any Affiliate shall have the right and is hereby authorized to withhold from any payment due under this Plan or from any compensation or other amount owing to the Participant, applicable withholding taxes
with respect to any payment under this Plan and to take such action as may be necessary in the opinion of the Company to satisfy all obligations for the payment of such withholding taxes. 

(g) Severability. If any provision of this Plan is held unenforceable, the remainder of the Plan shall continue in full force and
effect without regard to such unenforceable provision and shall be applied as though the unenforceable provision were not contained in the Plan. 
 (h) Governing Law. The Plan shall be governed by and construed in accordance with the laws of the State of North Carolina without regard to conflicts of laws. 

(i) Headings. Headings are inserted in this Plan for convenience of reference only and are to be ignored in a construction of the
provisions of the Plan. 

  
 6EX-10.58

 Exhibit 10.58 
 AMENDMENT NO. 1 TO 
 MANAGEMENT AGREEMENT 

AMENDMENT NO. 1 TO MANAGEMENT AGREEMENT, dated as of [            ],
2013 (the “Amendment”), by and among Quintiles Transnational Corp., a North Carolina corporation (the “Company”), Bain Capital Partners, LLC, a Delaware limited liability company (“Bain”), GF
Management Company, LLC, a North Carolina limited liability company (“GFM”), TPG Capital, L.P., a Texas limited partnership (“TPG”), Cassia Fund Management Pte Ltd., a Singapore corporation
(“Cassia”), 3i Corporation, a Massachusetts corporation (“3i,” and, together with Bain, GFM, TPG, 3i and Cassia, the “Managers”) and Aisling Capital, LLC (“Aisling”). Capitalized
terms used herein but not defined shall have the meaning ascribed to such terms in the Management Agreement, dated as of January 22, 2008, by and among the Company, the Managers and Aisling (the “Management Agreement”). Except
as provided herein, all other terms, conditions and provisions of the Management Agreement shall remain in full force and effect. 
 RECITALS 
 WHEREAS, Section 8.2 of the Management Agreement provides that the
Management Agreement may be amended by a written instrument signed by each of the parties to the Management Agreement; 

WHEREAS, the parties to this Amendment desire to amend the Management Agreement in connection with a proposed initial public offering of
Quintiles Transnational Holdings Inc. (“Holdings”), of which the Company is a wholly-owned subsidiary; and 

WHEREAS, contemporaneously with and in consideration of the execution of this Amendment, (i) Holdings is adopting the Second Amended
and Restated Certificate of Incorporation, (ii) Holdings and certain shareholders identified therein are entering into the Second Amended and Restated Registration Rights Agreement, (iii) Holdings and certain shareholders identified
therein are entering into Amendment No. 1 to the Shareholders Agreement and (iv) the Company and Dennis B. Gillings, Ph.D., an affiliate of GFM, are entering into the Fifth Amendment to Executive Employment Agreement to, among other
things, limit certain expense reimbursements to GFM contained therein. 
 AGREEMENT 

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and agreements contained herein, and intending to be legally
bound hereby, the Company, the Managers and Aisling hereby agree as follows: 
  

	 	1.	A new Section 6.3 of the Management Agreement shall be inserted as follows: 

“6.3 Upon the termination of this Agreement immediately prior to the effective date of a Qualifying Offering pursuant
to clause (b) of Section 6.1, the Company shall pay termination fees, equal to USD $25.0 million in the aggregate, to Bain, GFM, TPG, 

 
3i, Cassia and Aisling, which fees shall be allocated as follows: (i) $5,934,402 to Bain, (ii) $5,934,402 to GFM, (iii) $5,934,402 to TPG, (iv) $3,921,006 to 3i,
(v) $2,525,788 to Cassia and (vi) $750,000 to Aisling.” 
  

	 	2.	A new Section 6.4 of the Management Agreement shall be inserted as follows: 

“6.4 Upon the termination of this Agreement immediately prior to the effective date of a Qualifying Offering pursuant
to clause (b) of Section 6.1, the Company shall pay to GFM an additional fee equal to USD $1,500,000, which shall be payable within ten (10) days following such Qualifying Offering.” 

This Amendment may be executed in any number of counterparts, each of which will be deemed an original, but all of which together
will constitute one and the same instrument.
 [Signature Pages Follow] 

  
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 [Signature Page to Amendment No. 1 to Management Agreement] 

 

 IN WITNESS WHEREOF, the Company, the Managers listed below and Aisling have executed and
delivered this Amendment No. 1 to the Management Agreement as of the date first above written. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	  

		 	Name:
		 	Title:
	
	BAIN CAPITAL PARTNERS, LLC
		
	By:	 	  

		 	Name:
		 	Title:
	
	GF MANAGEMENT COMPANY, LLC
		
	By:	 	  

		 	Name:
		 	Title:
	
	TPG CAPITAL, LP
		
	By:	 	  

		 	Name:
		 	Title:
	
	CASSIA FUND MANAGEMENT PTE LTD.
		
	By:	 	  

		 	Name:
		 	Title:

 [Signature Page to Amendment No. 1 to Management Agreement] 

 

			
	
	3i CORPORATION
		
	By:	 	  

		 	Name:
		 	Title:
	
	AISLING CAPITAL, LLC
		
	By:	 	  

		 	Name:
		 	Title:

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