Document:

EXHIBIT 10.58

                             LICENSE AGREEMENT***

      This License Agreement (this "Agreement"), dated as of June 1, 2002, is
made by and among Osteotech, Inc. a corporation organized and existing under the
laws of the State of Delaware, Osteotech Investment Corporation, a corporation
organized and existing under the laws of the State of New Jersey (collectively,
"Licensor"), Musculoskeletal Transplant Foundation ("MTF"), a non-profit
corporation organized under the laws of the District of Columbia, Biocon, Inc.,
a non-profit corporation organized under the laws of the District of Columbia
and the controlling parent corporation of MTF ("Biocon"; except as otherwise
provided in this Agreement, for purposes of this Agreement, the term "MTF" shall
include Biocon and all existing and future Affiliates of MTF and/or Biocon), and
Synthes Spine Company, L.P., a Delaware limited partnership ("Synthes"), MTF,
Biocon and Synthes being each a "Licensee").

      WHEREAS, Licensor and Licensees are parties to a certain litigation
relating to the parties' respective patent rights and have agreed to settle that
litigation; and

      WHEREAS, as part of such settlement, Licensor has agreed to grant certain
license rights to Licensees set forth herein in consideration for a commitment
on the part of MTF to make available to Licensor certain donor tissue for
processing under the Processing Agreement (as defined below); and

      WHEREAS, the purpose of the license rights granted by Licensor hereunder
is to allow Licensees to develop, make, use, sell and distribute Licensed
Products (as defined below) throughout the world, subject to the terms and
conditions set forth below; and

      WHEREAS, as part of such settlement, MTF has agreed to grant certain
license rights under certain MTF patents to Licensor, with the purpose of
allowing Licensor to develop, make, use, sell and distribute certain 558/655
Products (as defined below) covered by such MTF Patents throughout the world,
subject to the terms and conditions set forth below.

      In consideration of the mutual covenants contained herein, the receipt and
sufficiency of which is hereby acknowledged, the parties agree as follows:

                            ARTICLE I - DEFINITIONS

      As used in this Agreement, the following terms will have the meanings set
forth below:

            "558/655 Products" shall mean products covered by Licensor's United
States Patents 5,290,558 and 5,284,655 (or corresponding foreign patents).

            "Affiliate" shall mean any corporation or other entity that
directly, or indirectly through one or more intermediaries, controls, is
controlled by, or is under common control with the designated party but only for
so long as such relationship exists. For purposes of this definition, control
means ownership of at least fifty percent (50%) of the shares of stock entitled

----------

***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-61
<PAGE>

to vote for directors in the case of a corporation, and of at least fifty
percent (50%) of the interests in profits of a business entity other than a
corporation or the right by contract or otherwise to elect or appoint a majority
of the members of the board of directors or other governing body of a
corporation or other business entity.

            "Best Efforts" shall mean as to a party hereto, an undertaking by
such party to perform or satisfy an obligation or duty or otherwise act in a
manner reasonably calculated to obtain the intended result by action or
expenditure not disproportionate or unduly burdensome in the circumstances
without the requirement in any case to commence litigation or other legal
proceedings.

            "Bone Powder" shall mean a bone mixture in which the majority of any
bone particles have: (i) a length to width ratio of *** or less (where length is
the longest single dimension and width is the longest dimension measured
perpendicular to the length); and (ii) a length less than ***.

            "Customer" shall mean any (a) hospital, (b) physician or (c) MTF
member organization that recovers donors for MTF, that places one or more orders
for a Licensed Product in the Territory.

            "Designated Distributor" shall mean a distributor that has annual
sales of orthopedic products and a number of sales representatives representing
orthopedic products that are less than the corresponding annual sales and number
of sales representatives of Synthes.

            "Donor" shall mean a Standard Donor or a Non-Standard Donor from
whom Tissue is to be (or has been) procured and delivered by MTF in accordance
with the provisions of this Agreement or the Processing Agreement.

            "Donor Commitment" shall mean the "Donor Commitment" as defined in
the Processing Agreement.

            "Effective Date" shall mean the "Effective Date" as defined in the
Processing Agreement.

            "Licensed Patent Rights" shall mean the rights of Licensor in and to
the Osteotech Licensed Patents.

            "Licensed Products" shall mean MTF's or Biocon's bone filler
products that have all the following features:

            (a) comprised of demineralized and/or partially demineralized Bone
Powder in a carrier; and

            (b) the carrier is

----------

***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-62
<PAGE>

                  (i)   one or more of the following carriers: ***

                  (ii) derivatives or mixtures of any of the foregoing listed
            carriers (where derivative refers to a modification of the carrier
            molecule's backbone to include side-group, end-group or cross link
            modifications).

      (c) Without limiting the foregoing, Licensed Products shall also include:

                  (i) bone filler products as specified above that are
            supplemented with ***

                  (ii) the product identified under the mark DBX(R) as
            manufactured, formulated and commercialized by Licensees before the
            Effective Date, even if such product may fall within one or more of
            the exclusions listed under Osteotech Licensed Patents or future
            patent rights under Osteotech License Patents.

                  (iii) Notwithstanding the foregoing, except as set forth in
            clause (ii) above with respect to DBX(R), Licensed Products do not
            include:

                        (1) any product covered by U.S. Patents, 5,284,655 or
                  5,290,558 that is not a Licensed Product as described above;
                  or

                        (2) any implant containing a component that is
                  specifically added to act as a resorbable radiopaque marker.

            "MTF Tissue" shall mean Tissue obtained from MTF Donors (as defined
in the Processing Agreement).

            "Osteotech Tissue" shall mean Tissue obtained from Osteotech Donors
(as defined in the Processing Agreement).

            "Osteotech Licensed Patents" shall, subject to the exclusions set
forth below, mean:

            (a)    United States Patents 5,290,558 and 5,284,655, and any other
U.S. or foreign patent owned by or licensable by Licensor and issued as of the
Effective Date other than those listed in Schedule 1.0 attached; and

            (b)    the following future patent rights:

                        (i) U.S. and foreign patents owned by or licensable by
                  the Licensor that issue after the Effective Date on an
                  application owned by or

----------

***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-63
<PAGE>

                  licensable by Licensor and pending as of the Effective Date,
                  and any divisions, continuations and continuations-in-part
                  based on such applications (but only to the extent of claims
                  in such continuations-in-part enablingly disclosed in a patent
                  application pending as of the Effective Date); and

                        (ii) any other future U.S. or foreign patent right
                  granted to or acquired by Licensor on an application filed
                  after the Effective Date and owned by or licensable by
                  Licensor during the term of this Agreement ; and

            (c) any reissue or reexamination patent issued on a patent covered
by clause (a) or (b);

to the extent that such future patent rights under clauses (b) or (c) cover a
Licensed Product and Licensees demonstrate that their prior development work on
such Licensed Product covered by such future patent rights meets or exceeds, as
of the earliest publication date for the patent application leading to such
future patent rights, the Prior Development Threshold in accordance with the
prior development resolution provisions of Section 10.14 below. In the event
Licensees cannot satisfy the Prior Development Threshold, to the extent a future
patent right within clauses (b) or (c) above and owned or licensable by Licensor
includes a claim for which Licensor cannot, as of the date of issue of such
patent, show prior development work that meets the Prior Development Threshold,
Licensor agrees not to assert such claim against Licensees to the extent
Licensees are making a Licensed Product.

            A patent right is considered "licensable by" Licensor if Licensor is
permitted to grant a license or sublicense to Licensees but only if the grant
and use of such license or sublicense require no consideration to be paid by
Licensor. In no event are patent rights of any third party included as Osteotech
Licensed Patents, unless these are "licensable by" Licensor.

            The foregoing definition of Osteotech Licensed Patents specifically
excludes any claims in those patents listed in Schedule 1.0, except to the
extent they (i) cover any method or process actively used by Licensees for
Licensed Products commercialized before the Effective Date, or (ii) fall within
the provisions of Section 2.1(d).

            "Payment in Cash" shall mean: (a) a payment in the amount of
$500,000 in immediately available funds in the period on or after January 1,
2009 and not later than January 15, 2009; and (b) a payment in the amount of
$500,000 in immediately available funds in the period on or after January 1,
2010 and not later than January 15, 2010.

            "Prior Development Threshold" shall mean a level of product
development as defined in Section 10.14 below.

            "Processing Agreement" shall mean that certain Second Amended and
Restated Processing Agreement by and among Licensor, MTF and Biocon, dated as of
June 1, 2002, a copy of which is attached hereto as Exhibit A.

            "Settlement Agreement" shall mean that certain Settlement Agreement
a copy of which is attached hereto as Exhibit B.

                                                                            E-64
<PAGE>

            "Standard Donor" shall mean: (i) a human male not less than ***
years of age and not greater than *** years of age at date of death; or (ii) a
human female not less than *** years of age and not greater than *** years of
age at date of death. "Non-Standard Donor" shall mean: (i) a human male not less
than *** years of age and not greater than *** years of age at date of death; or
(ii) a human female not less than *** years of age and not greater than ***
years of age at date of death.

            "Synthes Agreements" shall mean the following agreements, including
the amendments thereto as of the date of this Agreement: ***

            "Territory" shall mean the world.

            "Tissue" shall mean human bone and related connective soft tissue.

      In this Agreement the singular includes the plural and the plural the
singular; references to statutes or regulations are to be construed as including
all statutory or regulatory provisions consolidating, amending or replacing the
statute or regulation referred to; references to "writing" including printing,
typing, lithography and other means of reproducing words in a tangible visible
form; references to articles, section (or subdivisions of sections), exhibits,
annexes or schedules are to this Agreement unless otherwise indicated;
references to agreements and other contractual instruments shall be deemed to
include all schedules and exhibits to such agreement and all subsequent
amendments and other modifications to such agreements and contractual
instruments, but only to the extent such amendments and other modifications are
not prohibited by the terms of this Agreement, unless otherwise indicated; and
references to persons or entities include their respective permitted successors
and assigns and, in the case of any governmental entity, governmental entities
succeeding to their respective functions and capacities. The headings used in
this Agreement are for convenience only and shall not be deemed to constitute a
part hereof.

                         ARTICLE II - GRANT OF LICENSE

      2.1 GRANT OF LICENSE. (a) In exchange for the consideration set forth in
Article III hereof and the due performance of all of the terms of this
Agreement, Licensor hereby grants to MTF and its Affiliates a non-exclusive,
worldwide license under the Osteotech Licensed Patents solely to make, use,
sell, offer to sell, distribute, import and/or export Licensed Products directly
to Customers of MTF and Customers of MTF's Affiliates in the Territory. MTF and
its Affiliates shall have no right to grant any sublicense or delegate any
rights whatsoever under the license granted to them herein, except that Licensed
Products made by MTF or its Affiliates may be sold or distributed directly by
(i) Synthes and its Affiliates, (ii) individual sales agents or local or
regional distributors retained by MTF to fill gaps in the coverage of its
employed sales force, (iii) Designated Distributors that will represent or
distribute Licensed Products that are not represented or distributed by Synthes
or its Affiliates, and are approved in writing by Osteotech (which approval will
not be unreasonably withheld, conditioned, or delayed), and (iv) any other

----------

***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-65
<PAGE>

distributors approved in writing by Osteotech in its sole discretion, in each
case solely to their respective Customers in the Territory; and Licensees' and
such distributors' Customers may use the Licensed Products in the Territory.
Notwithstanding the foregoing, in the event the agreement between MTF and
Synthes whereby Synthes shall have the right to distribute the Licensed Products
made by MTF shall terminate during the term of the license granted herein, MTF
shall have the right to (i) notify Osteotech of such termination, (ii) grant
another distributor, which has annual sales from orthopedic products and a
number of sales representatives representing orthopedic products that are
comparable to Synthes' annual sales of orthopedic products and the number of
sales representatives Synthes has representing orthopedic products as at the
time of such termination, the right to sell and distribute Licensed Products
directly to its Customers in the Territory and (iii) notify Osteotech of the
identity of such replacement distributor and provide Osteotech with such other
information as Osteotech shall request to verify that such replacement
distributor meets the qualifications set forth in clause (ii) above. Nothing in
this Section 2.1, or this Agreement generally, shall be deemed to reduce,
eliminate, or otherwise affect the relative rights and duties of MTF and Synthes
under their existing agreements, provided that Synthes has modified the
competitive restrictions in such agreements to the extent necessary to allow MTF
to perform its obligations under the Processing Agreement, including without
limitation MTF's obligation to deliver MTF Tissue and Osteotech Tissue to
Osteotech in accordance with the Processing Agreement. Synthes will take no
action to prevent or restrict MTF from performing its obligations under the
Processing Agreement.

            (b) In exchange for the consideration referred to in Article III
hereof and the due performance of all of the terms of this Agreement, Licensor
hereby grants to Synthes and its Affiliates a non-exclusive, worldwide license
under the Osteotech Licensed Patents solely to (i) use, and to sell, offer to
sell, distribute, import and/or export Licensed Products made by MTF or its
Affiliates solely and directly to Customers of MTF and Customers of MTF's
Affiliates and Customers of Synthes and Customers of Synthes' Affiliates in the
Territory and (ii) to make or have made Licensed Products to the extent and only
to the extent such Licensed Products are represented or distributed by Synthes
pursuant to the Synthes Agreements. Except as provided in the preceding
sentence, the license granted herein to Synthes and its Affiliates shall not
provide Synthes or its Affiliates with any right to make any Licensed Product or
have any Licensed Product made by any person other than MTF or MTF's Affiliates.
Synthes and its Affiliates shall have no right to grant any sublicense or
delegate any rights whatsoever under the license granted to them herein, except
that Licensed Products may be used by Licensees' Customers. Notwithstanding
anything to the contrary in this Agreement, all license rights granted to
Synthes and its Affiliates under this Agreement are for the sole purpose of
enabling Synthes to perform its obligations and enjoy its benefits under the
Synthes Agreements. Accordingly, the license rights granted to Synthes and its
Affiliates hereunder shall terminate and expire simultaneously with the
termination of the relevant Synthes Agreement unless such rights are earlier
terminated as provided in this Agreement. MTF shall notify Osteotech promptly
after any such termination shall occur.

            (c) In exchange for the consideration referred to in Article III
hereof and the due performance of all of the terms of this Agreement, Licensor
hereby grants to MTF a non-exclusive right to use in connection with Licensed
Products any know-how or confidential information of Licensor that is solely
related to the processing of Licensed Products and is in

                                                                            E-66
<PAGE>

MTF's possession as of the Effective Date and is the subject of the lawsuit
being settled pursuant to the Settlement Agreement, to the extent such know-how
or confidential information exists. The right to use know-how and confidential
information contained in this Section 2.1(c) shall not cover or relate to
know-how or confidential information of Licensor obtained by Licensees
subsequent to the date of this Agreement, unless such know-how or confidential
information: (1) was in the possession of Licensees prior to disclosure by
Licensor; or (2) is or becomes public knowledge through no fault or omission of
Licensees; or (3) is obtained by Licensees from a third party under no
obligation of confidentiality to Licensor.

            (d) The license to Licensees shall permit Licensees to develop,
make, have made, use, offer to sell, sell, distribute, and otherwise
commercialize those Licensed Products covered by the license as permitted in
Section 2.1 herein. In addition to the licenses granted in sections 2.1(a) and
(b), Licensor grants to MTF and Synthes licenses as set forth in sections 2.1(a)
and (b) above for: (i) U.S. Patent No. 5,676,146 and U.S. Reexam Patent No. B1
5,676,146, as listed in Schedule 1.0, to the extent the claims of these patents
cover Licensed Products that do not contain a component that is specifically
added to act as a resorbable radiopaque marker; provided that neither Licensee,
no Affiliate of a Licensee and no persons selling Licensed Products for a
Licensee or any Affiliate of a Licensee shall promote any Licensed Product as
having a resorbable radiopaque marker feature; and (ii) U.S. Patent No.
6,332,779 B1, as listed in Schedule 1.0, to the extent the claims of this patent
cover any Licensed Products; provided that neither Licensee, no Affiliate of a
Licensee and no persons selling Licensed Products for a Licensee or any
Affiliate of a Licensee shall promote any Licensed Product as usable in the
method claimed in this patent.

            (e) The only consideration or payments that will be due from
Licensees to Licensor in connection with the grant of licenses granted under
this Section 2.1 shall be the consideration referred to in Article III hereof
and the due performance of all of the terms of this Agreement.

      2.2 LIMITATION AS TO RIGHTS. (a) Except as otherwise provided in this
Agreement, no Licensee will, as a result of this Agreement, obtain any ownership
interest in or other rights to any technology, know-how, trade secrets, patent
applications or patents, or other intellectual property, products, or materials
of Licensor, and Licensor shall have no obligation whatsoever to supply to
either Licensee any such ownership interest or other rights.

            (b) Except as otherwise provided in this Agreement, the Licensor
will not, as a result of this Agreement, obtain any ownership interest in or
other rights to any technology, know-how, trade secrets, patent applications or
patents, or other intellectual property, products, or materials of Licensees,
and Licensees shall have no obligation whatsoever to supply Licensor any such
ownership interest or other rights.

      2.3 DISCLAIMER. OTHER THAN AS EXPRESSLY PROVIDED IN SECTION 4.5 HEREOF,
LICENSOR MAKES NO WARRANTIES, EXPRESS OR IMPLIED, REGARDING THE OSTEOTECH
LICENSED PATENTS OR THE LICENSED PATENT RIGHTS, AND LICENSOR ASSUMES NO
RESPONSIBILITY FOR INTELLECTUAL PROPERTY RIGHTS INFRINGEMENTS OR ANY OTHER
CLAIMS ARISING FROM OR WITH RESPECT TO THE EXERCISE OR USE OF THE LICENSED
PATENT RIGHTS OR

                                                                            E-67
<PAGE>

LICENSED PRODUCTS. LICENSOR WILL NOT BE LIABLE FOR ANY INDIRECT, INCIDENTAL,
SPECIAL OR CONSEQUENTIAL DAMAGES (INCLUDING WITHOUT LIMITATION LOSS OF PROFIT OR
LOSS OF USE) ARISING DIRECTLY OR INDIRECTLY OUT OF THIS AGREEMENT, INCLUDING AS
A RESULT OF ANY BREACH, DELAY OR DEFAULT ON THE PART OF LICENSOR. THE
LIMITATIONS ON AND EXCLUSIONS FROM LIABILITY HEREUNDER WILL APPLY WHETHER A
CLAIM ARISES IN CONTRACT, TORT, STRICT LIABILITY OR OTHERWISE, AND EVEN IF
LICENSOR HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES.

                          ARTICLE III - CONSIDERATION

      3.1 CONSIDERATION. In consideration for the grant of the licenses granted
herein MTF hereby agrees:

            (a) To deliver to Licensor, in full compliance with and subject to
the terms and conditions of the Processing Agreement, Tissue from Donors
constituting the Donor Commitment.

            (b) In addition to the obligations set forth above, MTF shall be
liable to pay to Licensor each Payment in Cash when and as due. In the event
that a cash payment due hereunder by MTF to Licensor is not made on or prior to
the date it is due hereunder, MTF shall pay to Licensor interest at the lower of
(i) the highest rate permitted by law or (ii) the prime rate charged by
CitiBank, N.A. as stated in The Wall Street Journal, New York edition, on the
date such payment is due (or the immediately preceding business date if such
payment date is not a business date) plus three percent (3%), in either case on
the outstanding balance until such balance, including such interest, is paid in
full to Licensor. The acceptance by Licensor of any such late payment will not
act as a waiver of any rights Licensor may have hereunder due to a breach by MTF
relating to such late payment.

                              ARTICLE IV - PATENTS

      4.1 FILING AND MAINTENANCE. Licensor will at all times own and have total
discretion and control over the filing of any patent applications and
prosecution and maintenance of any and all patents included within the Licensed
Patent Rights.

      4.2 MARKING. Each Licensee will place or cause to be placed, and will
require its distributors and sales agents to place or cause to be placed on or
in the packaging for each Licensed Product and not to remove from any Licensed
Product, a patent marking notice as follows: "Pat. nos. 5,290,558; 5,284,655",
if the Licensed Product is covered by such patents and if Licensor also marks
its comparable products covered by these patents and made from MTF Tissue in the
same or a similar manner (including Licensor's Grafton(R) Products distributed
by MTF), such marking to be for the purposes of 35 U.S.C. Section 287(a)
(subject to the requirements of the patent laws and regulations in the
jurisdictions where such Licensed Product is made or sold). In the event that
Licensor identifies any Licensed Product as covered by any additional patent
included in the Licensed Patent Rights, Licensor may give Licensee notice
identifying such additional patent and the number of that patent shall (absent a
good faith

                                                                            E-68
<PAGE>

dispute as to the coverage of that patent) be included in the above patent
marking notice for such covered Licensed Product.

      4.3 TIMING OF MARKING. Licensees shall take immediate steps following the
Effective Date of this Agreement to implement the required patent marking notice
for DBX(R), but shall have up to one year to use up any normal inventory of
packaging for DBX(R) that Licensees have on hand as of the Effective Date.
Future Licensed Products shall be marked from the date of Licensees' first sale
or, in the case of additional patents as to which Licensor has provided notice,
within a reasonable time following such notice.

      4.4 GRANT OF LICENSE TO LICENSOR. Subject to the exclusions set forth
below, MTF hereby grants to Licensor a worldwide, royalty-free, non-exclusive
license under:

            (a) except for U.S. Patent Nos. 6,030,635 and 6,326,018 and any
continuations, continuations-in-part, (but only to the extent of claims in such
continuations-in-part enablingly disclosed in a patent application pending as of
the Effective Date), divisionals, reissues or reexaminations of those patents or
foreign counterparts therof, any issued U.S. or foreign patent owned by or
licensable by MTF as of the Effective Date, to the extent such patent covers any
558/655 Product that is manufactured, formulated and commercialized by Licensor
before the Effective Date or covers any method or process actively used for such
558/655 Product before the Effective Date, even if such 558/655 Product may fall
within one or more of the exclusions listed below; and

            (b) the following future patent rights:

                  (i) U.S. and foreign patents owned by or licensable by MTF
            that issue after the Effective Date on an application owned or
            licensable by MTF and pending as of the Effective Date, and any
            divisions, continuations and continuations-in-part based on such
            applications (but only to the extent of claims in such
            continuations-in-part enablingly disclosed in a patent application
            pending as of the Effective Date); and

                  (ii) any other future U.S. or foreign patent right granted to
            or acquired by MTF on an application filed after the Effective Date
            and owned by or licensable by MTF during the term of this Agreement;
            and

            (c) any reissue or reexamination patent issued on a patent licensed
by clause (a) or (b);

to the extent such future patent rights under clauses (b) or (c) cover a 558/655
Product and Licensor demonstrates that its prior development work on such
558/655 Product covered by such future patent rights meets or exceeds, as of the
earliest publication date for the patent application leading to such future
patent rights, the Prior Development Threshold in accordance with the prior
development resolution provisions of Section 10.14 below. In the event Licensor
cannot satisfy the Prior Development Threshold, to the extent a future patent
right within clauses (b) and (c) above and owned or licensable by MTF includes a
claim for which MTF cannot, as of the date of issue of such patent, show prior
development work that meets the Prior Development

                                                                            E-69
<PAGE>

Threshold, MTF agrees not to assert such claim against Licensor to the extent
Licensor is making a 558/655 Product.

            The license to Licensor shall permit Licensor to develop, make, have
made, use, offer to sell, sell, distribute, and otherwise commercialize those
558/655 Products covered by the license of MTF's above-identified patents as
permitted in Section 4.4 herein.

            A patent right is considered "licensable by" MTF if MTF is permitted
to grant a license or sublicense to Licensor, but only if the grant and use of
such license or sublicense requires no consideration to be paid by MTF. In no
event are patent rights of any third party included as part of this license by
MTF, unless these are "licensable by" MTF.

            The foregoing grant to Licensor shall not provide Licensor any right
to grant any sublicense with respect to the subject matter thereof except to the
extent reasonably necessary to support use of 558/655 Products by Licensor's
customers.

            The following list of exclusions does not prevent Licensor from
making any product that is excluded from 558/655 Products; however, no such
excluded product will be authorized under any patents owned by or licensable by
MTF. In addition to the limitations set forth above, the foregoing limited
non-exclusive license from MTF to Licensor expressly excludes any right to make,
have made, use, offer to sell, sell, distribute, or otherwise commercialize the
product identified under the mark DBX(R) as manufactured, formulated and
commercialized by Licensees before the Effective Date, or any claim of any
patent or patent application owned by or licensable by MTF that covers:

            (x) any components of the Licensed Products; or

            (y) a method or process for making the Licensed Products, or a bone
filler product carrier, supplement or other component or any osteogenic
composition or implant or any osteoplasty material claimed in a patent owned by
or licensable by MTF; or any bone filler product or composition that is not
claimed or disclosed in United States Patents 5,290,558 or 5,284,655.

            The limited, non-exclusive license granted by MTF in this section
does not include any rights under any Synthes patents or patent applications.

      4.5 WARRANTIES REGARDING LICENSES.

            (a) Licensor represents and warrants that, as of the Effective Date,
Licensor has the legal right and authority to grant the license to Licensees set
forth herein.

            (b) MTF represents and warrants that, as of the Effective Date, MTF
has the legal right and authority to grant the license to Licensor set forth
herein.

                                                                            E-70
<PAGE>

                    ARTICLE V - INFRINGEMENT BY THIRD PARTY

      5.1 NOTICE OF ALLEGED INFRINGEMENT BY THIRD PARTY. If either Licensee
believes that the Osteotech Licensed Patents as they pertain to Licensed
Products are infringed by a third party, such Licensee will promptly notify the
Licensor in writing, which notice will set forth the facts of such infringement
in reasonable detail as known to the notifying party. If Licensor believes that
the Osteotech Licensed Patents as they pertain to Licensed Products are
infringed by a third party, Licensor will promptly notify the Licensees in
writing, which notice will set forth the facts of such infringement in
reasonable detail as known to the notifying party.

      5.2 RESOLUTION OF THIRD-PARTY INFRINGEMENT DISPUTES. Licensor will have
the sole right, but not the obligation, to resolve disputes with respect to
infringement by a third party of Osteotech Licensed Patents. Licensees shall
have no right to enforce or defend the Osteotech Licensed Patents, to file or
institute any claims, suits or proceedings seeking to enforce or defend the
Osteotech Licensed Patents or otherwise in relation to the Osteotech Licensed
Patents or to otherwise resolve disputes with respect to the Osteotech Licensed
Patents.

                ARTICLE VI - EFFECTIVENESS; TERM AND TERMINATION

      6.1 TERM. This Agreement shall, when it has been executed by all the
Parties hereto, become effective as of the Effective Date and, unless earlier
terminated as provided herein, this Agreement will remain in effect until
February 28, 2011.

      6.2 SPECIAL RIGHTS AND REMEDIES OF LICENSOR. (a) Licensees agree and
acknowledge that the delivery to Licensor of the Donor Commitment referred to in
Article III hereof is fundamental to Licensor's business and that MTF's failure
to comply with its obligations to deliver to Licensor, in full compliance with
and subject to the terms and conditions of the Processing Agreement, Tissue from
Donors constituting the Donor Commitment in compliance with Section 3.1 hereof
will cause irrevocable harm to Licensor, and therefore Licensees hereby
irrevocably agree that: (A) Licensor shall be entitled to immediate preliminary
and final injunctive relief and to enforce specific performance in respect of
such obligations; and (B) in the event MTF's failure to comply with its
obligations under Section 3.1 hereof is due to the fact that MTF makes a
determination to permanently cease, and has ceased, procuring donors for all
purposes (specifically excluding temporary interruptions resulting from
regulatory, safety, market, or similar conditions), (i) Licensor shall be
entitled to, at its sole election, cause (via immediate preliminary and final
injunctive relief or otherwise, in its discretion) all Licensed Products to be
immediately withdrawn from all markets, and (ii) the licenses granted by
Licensor pursuant to Article II hereof may, at Licensor's sole discretion, be
terminated upon three (3) business-days' notice to Licensees at any time;
provided that if such licenses are terminated pursuant to this Section
6.2(a)(B)(ii), Licensees shall be entitled to distribute their inventory of
Licensed Products in existence on the date of such termination for a period of
three (3) months, after such date of termination.

            (b) Without limiting any other right or remedy of Licensor under
this Agreement, the parties agree that in the event all Licensed Products
marketed by Licensees are

                                                                            E-71
<PAGE>

voluntarily or involuntarily withdrawn from the market and commercialization by
Licensees of all Licensed Products has ceased:

                  (i) MTF shall continue for a period of 24 consecutive months
            commencing on the date of such withdrawal, to deliver to Licensor
            all Tissue required by the Donor Commitment under this Agreement and
            the Processing Agreement and to comply with its obligations under
            the Processing Agreement notwithstanding such withdrawal. Licensees
            may, after the expiration of such 24-month period and subject to
            compliance by MTF with its obligations set forth in the preceding
            sentence and upon 6 months prior written notice to Licensor,
            terminate this Agreement; and

                  (ii) if, after such termination, any Licensed Product is
            reintroduced into the market or either Licensee shall market in any
            fashion any Licensed Product, this Agreement shall be fully
            reinstated as of the date of such reintroduction or commencement of
            marketing as if this Agreement had not been terminated.

            (c) Licensees agree and acknowledge that this Agreement and the
Processing Agreement are entered into as part of a larger settlement as
referenced in Article IX below and that the invalidity of one or more claims of
any of the Osteotech Licensed Patents shall not affect Licensees' performance of
their obligations under this Agreement, the Processing Agreement or the
Settlement Agreement.

      6.3 TERMINATION FOR DEFAULT. (a) In addition to its other rights and
remedies, Licensor may terminate this Agreement:

                  (i) in the event any Licensee breaches any of its material
            obligations under this Agreement and Licensees fail to cure such
            breach within ninety (90) days after receipt of written notice from
            Licensor setting forth in reasonable detail the nature of such
            alleged breach; and

                  (ii) simultaneously with the termination of the Processing
            Agreement for any reason, except where the Processing Agreement is
            terminated by MTF pursuant to Sections 8.1(a), 8.4 or 8.5 thereof.

            (b) In addition to their other rights and remedies, Licensees may
terminate this Agreement in the event Licensor breaches any of its material
obligations under this Agreement and Licensor fails to cure such breach within
ninety (90) days after receipt of written notice from Licensees setting forth in
reasonable detail the nature of such alleged breach, provided that if this
Agreement is terminated by Licensees under this Section 6.3(b), the Processing
Agreement shall remain in effect in accordance with its terms, including without
limitation MTF's obligation to deliver to Osteotech the Tissue from Donors
constituting the Donor Commitment.

      6.4 TERMINATION FOR INSOLVENCY, ETC. Either Licensor or MTF may terminate
this Agreement effective upon written notice to the other party if (a) the
non-notifying party becomes insolvent or makes an assignment for the benefit of
creditors, (b) a receiver is appointed for the non-notifying party, or (c)
bankruptcy proceedings are instituted by or against the non-notifying party.
Without limiting any of any party's rights under any other provision of

                                                                            E-72
<PAGE>

this Agreement, each party's rights under this Agreement will include those
rights afforded by 11 U.S.C. ss.365(n) of the United States Bankruptcy Code and
any successor thereto (the "Code"). If the bankruptcy trustee of a party as a
debtor or such party as a debtor-in-possession rejects this Agreement under 11
U.S.C. ss.365(n) of the Code, either other party may elect to retain its rights
hereunder for the duration of this Agreement and avail itself of all rights and
remedies to the full extent contemplated by this Agreement, 11 U.S.C. Code
ss.365(n), and any other relevant sections of the Code or other relevant
non-bankruptcy law.

      6.5 ADVERSE CHANGE OF CONTROL. In the event that Regeneration Technologies
Inc. ("RTI") shall have acquired direct ownership of more than 50% of the voting
shares of Licensor or shall have directly caused the election of persons
nominated by it to membership on the board of directors of Licensor so that such
persons constitute a majority of the membership of such board, then Licensees
shall have the right, exercisable solely by delivery of written notice to
Licensor from both Licensees within 30 days of the occurrence of such event, to
terminate this Agreement effective upon payment to Licensor of the Termination
Fee (as defined below); provided that such right may only be exercised if the
Processing Agreement is simultaneously terminated pursuant to the provisions of
Section 8.5 thereof. The Termination Fee shall be the net present value to
Licensor, determined at the time of exercise of the rights referred to in this
Section 6.5, of the remaining obligations of Licensees under this Agreement for
the remainder of its term. Licensor and Licensees will negotiate in good faith
to agree on the Termination Fee, which the parties intend to be the net present
value to Licensor of the Processing Agreement at the time of termination. If
such agreement is not reached within 30 days after the occurrence of the change
in control event involving RTI, the Termination Fee shall be determined by an
appraiser jointly selected by Licensees and Licensor, which appraiser shall
submit to the parties a report within 30 days of its engagement setting forth
such determination. If the parties are unable to agree on an appraiser within 45
days after failing to reach agreement on the Termination Fee, within seven days
thereafter, each party shall submit the names of two nationally recognized firms
that are engaged in the business of valuing non-public securities, and each
party shall be entitled to strike one name from the other party's list of firms,
and the appraiser shall be selected by lot by the remaining two firms. The
expenses of such appraiser shall be shared equally by the Licensees, on the one
hand, and the Licensor, on the other hand. The determination of any such
appraiser as to the Termination Fee shall be final and binding on all parties.

      6.6 EFFECT OF TERMINATION. Termination of this Agreement for any reason,
other than for the reasons set forth in Section 6.1, Section 6.3(b) or Section
6.5 (in the event Licensees pay the Termination Fee), or as a result of the
termination of the Processing Agreement by MTF pursuant to Sections 8.1(a), 8.4
or 8.5 of the Processing Agreement, will result in automatic termination of the
licenses granted under Section 2.1 hereof and reversion of such licenses to
Licensor with neither Licensee having any residual rights with respect thereto
whatsoever and the license granted to Licensor under Section 4.4 hereof shall
convert to a fully-paid, non-exclusive license until the expiration of the last
to expire valid claim of the patents licensed by MTF in Section 4.4. In the
event this Agreement is terminated for the reasons set forth in Section 6.1,
Section 6.3(b) or Section 6.5 (in the event Licensees pay the Termination Fee),
or as a result of the termination of the Processing Agreement by MTF pursuant to
Sections 8.1(a), 8.4 or 8.5 of the Processing Agreement, each of the licenses
granted to Licensees under

                                                                            E-73
<PAGE>

Section 2.1 hereof shall convert to a fully-paid, non-exclusive license until
the expiration of the last to expire valid claim of the Osteotech Licensed
Patents, and each of the licenses granted to Licensor pursuant to Section 4.4
shall automatically terminate and revert to Licensees with Licensor having no
residual rights with respect thereto whatsoever. Termination of this Agreement
will not affect any rights or obligations of the parties accrued prior to the
effective date of such termination, including without limitation obligations
with respect to payments accrued hereunder prior to the effective date of such
termination, or any indemnity obligations of either party under this Agreement.

                            ARTICLE VII - PUBLICITY

      The parties shall cooperate in attempting to provide each other with
advance notice and the contents of any public announcement with respect to the
subject matter (or the fact of existence) of this Agreement. Nothing in this
Article VII shall prohibit a party from making any disclosure to the extent such
disclosure is deemed necessary under any applicable federal or state securities
laws or any rule or regulation of any nationally recognized securities exchange.
Once this Agreement has been filed with the SEC, any party may make public or
private announcements or statements with respect to the subject matter of this
Agreement, except such portions of this Agreement as have been designated as
confidential by the SEC. The party filing the Agreement with the SEC shall
consult with the other parties in determining the sections of this Agreement for
which such filing party shall request confidential treatment by the SEC, but
such filing party shall make the final determination in this regard.

                     ARTICLE VIII - INDEMNITY AND INSURANCE

      8.1 INDEMNIFICATION BY LICENSEES. Each Licensee will severally indemnify,
defend, and hold harmless Licensor and its Affiliates and their respective
directors, officers, employees and agents (collectively the "Indemnified
Parties") from and against any and all liabilities, claims (including product
liability claims), and suits asserted by a third party and all losses, damages,
costs, fees, and expenses (including without limitation attorneys' fees and
costs of litigation, regardless of outcome) suffered or incurred by the
Indemnified Parties, (collectively, "Liabilities") arising from actions or
inactions of the respective Licensee, relating to the Licensed Products,
including Liabilities resulting directly or indirectly from the (a) research,
development, manufacture, distribution, marketing, use or sale of Licensed
Products by or on behalf of the Licensee or its Affiliates, including without
limitation the shipment, handling, storage or distribution of Licensed Products,
or (b) the infringement or alleged infringement of any patents or intellectual
property rights arising from or related to the manufacture, use, sale or
distribution of Licensed Products, or (c) negligence, willful misconduct, breach
of this Agreement or violation of any law or regulation by the Licensee or any
of its Affiliates or any of their respective employees, agents or contractors.
If a court finds in an underlying action brought by a third party that Licensees
are jointly and severally liable to the third party, the Licensees shall be
jointly and severally responsible for the indemnification to the Indemnified
Parties provided under this Section 8.1. The foregoing obligation to defend,
indemnify and hold harmless will not apply to the extent any such Liabilities
result from gross negligence or willful misconduct by Licensor. The foregoing
provisions shall not apply to Licensed Products which are processed solely by
Licensor out of MTF Tissue and delivered to MTF under the Processing

                                                                            E-74
<PAGE>

Agreement, as to which the indemnification provisions of the Processing
Agreement shall govern.

      8.2 CONDITIONS. Licensees' indemnification obligations under Section 8.1
hereof are conditioned upon the Licensor:

            (a) Notice. Promptly notifying the Licensees in writing of the claim
or action against which indemnification is sought under Section 8.1 hereof,
provided, that failure to so notify the other parties will not eliminate
Licensees' obligation under this Article VIII, but will instead, entitle
Licensees to partial relief from such obligations only to the extent Licensees'
ability to satisfy such obligations are in fact directly limited or reduced by
such failure;

            (b) Opportunity. Providing the Licensees the opportunity to assume
the entire defense and settlement of such claim or action at Licensees' own cost
and expense; provided Licensor will have the right to be represented separately
by counsel of its own choosing at its own expense;

            (c) Cooperation. Cooperating with the Licensees (at Licensees'
expense) in the investigation and defense of such claim or action; and

            (d) Consent. Not settling or compromising such action or claim
without the prior written consent of Licensees; which consent will not be
unreasonably withheld or delayed.

      8.3 INSURANCE. Each Licensee will obtain, and maintain during the term of
this Agreement and for ten (10) years thereafter, product liability and general
liability insurance in commercially reasonable amounts as is customary for
similarly situated companies. There will be a thirty (30) day notice of
cancellation with respect to the required insurance coverage, with the provision
that Licensor be notified in the event of any cancellation, intention of insurer
not to renew, or any material change in the insurance contract or coverages
afforded. Such insurance will be placed with insurers having a Best's, Standard
and Poors, or similar rating of "A" or better. Each Licensee will be responsible
for the payment of any deductible or self-insured retention under such policies.
Within thirty (30) days after the Effective Date, each Licensee will furnish to
Licensor a customary certificate evidencing the insurance required under this
Section 8.3.

                   ARTICLE IX - SETTLEMENT OF PRIOR DISPUTES

      9.1 SETTLEMENT. This License Agreement has been entered into as part of
the settlement of litigation set forth in the Settlement Agreement.

      9.2 INVALIDITY OR UNENFORCEABILITY OF OSTEOTECH PATENTS. Notwithstanding
any terms of this Agreement, the Processing Agreement or the Settlement
Agreement; in the event in any action or proceeding any claim of any Osteotech
Licensed Patent is adjudged invalid or unenforceable against all persons and
such judgment becomes final with no further right of appeal, the claim(s)
invalidated or found unenforceable against all persons pursuant to such judgment
shall no longer be enforceable against Licensees. Nothing in this Agreement, the
Processing Agreement or the Settlement Agreement shall prevent Licensees from

                                                                            E-75
<PAGE>

challenging the validity or enforceability of any patent owned by Osteotech
other than U.S. Patent Nos. 5,290,558 or 5,284,655 as set forth in the
Settlement Agreement.

                           ARTICLE X - MISCELLANEOUS

      10.1 GOVERNING LAW. This Agreement will be governed by and interpreted in
accordance with the laws of the State of New Jersey, without regard for the
choice of law principles of such State or of any other jurisdiction.

      10.2 [Intentionally Omitted].

      10.3 REPRESENTATIONS AND WARRANTIES; FURTHER AGREEMENTS.

            (a) Each party hereby represents and warrants that: it has the full
legal authority to enter into this Agreement; this Agreement has been authorized
by all requisite action; and this Agreement constitutes its valid and binding
obligation and does not conflict with or violate any provision of any law, rule
or regulation or any contractual obligation applicable to it, and is enforceable
against it in accordance with its terms.

            (b) Licensees have read the Processing Agreement and hereby
acknowledge and agree that none of the provisions thereof conflict with or cause
a violation of any agreement by which either Licensee or any of its Affiliates
is bound, including without limitation, any agreement by and between the
Licensees, and agree that neither Licensee will, nor will it permit any of its
Affiliates to, enter into any agreement which creates any such conflict or
violation.

            (c) If Synthes shall have entered into an agreement with American
Red Cross Tissue Services ("ARCTS") providing, in form and substance reasonably
satisfactory to Osteotech, that ARCTS shall supply radius and ulna to either or
both Licensees from donors and in quantities reasonably acceptable to Osteotech,
Osteotech agrees to amend its agreement with ARCTS to eliminate supply by ARCTS
to Osteotech of radius and ulna except to the extent sufficient to process
Tissue for ARCTS' base tissue forms.

            (d) Licensor agrees not to assist any third party in initiating or
prosecuting any lawsuit against either of the Licensees or their respective
Affiliates, distributors, marketers, promoters and customers, relating to
alleged infringement of patents of such third parties involving Licensed
Products manufactured, used, sold, offered for sale, distributed, imported
and/or exported, by or on behalf of the Licensees and their respective
Affiliates; provided, that if Licensor is required, by subpoena or court order,
to testify or to otherwise provide information in connection with any lawsuit
brought by a third party, Licensor will so notify Licensees and will not be
deemed to be in violation of the foregoing in complying with such requirement.

            (e) Licensees acknowledge that the consideration to induce Licensor
to enter into this Agreement was the entering into the Processing Agreement by
MTF, and, therefore MTF hereby agrees that it will fully comply with its
obligations under the Processing Agreement and Licensees agree that material
failure of MTF to do so shall constitute a material breach of this Agreement.

                                                                            E-76
<PAGE>

      10.4 AMENDMENT. This Agreement may not be amended except by a written
agreement signed by all parties hereto.

      10.5 NOTICES. Any notice required by this Agreement will be sent by
registered or certified mail or delivered by courier or sent by facsimile to the
following:

       For Licensor:      Osteotech, Inc.
                          51 James Way
                          Eatontown, New Jersey 07724
                          Attention:  Chief Executive Officer
                          Facsimile:  (732) 935-0626

       For MTF:           Musculoskeletal Transplant Foundation
                          125 May Street
                          Edison, New Jersey 08837
                          Attention:  Chief Executive Officer
                          Facsimile:  (732) 661-2297

       For Biocon         Biocon, Inc.
                          125 May Street
                          Edison, New Jersey 08837
                          Attention:  Chief Executive Officer
                          Facsimile:  (732) 661-2297

       For Synthes        Synthes Spine Company, L.P.
                          1690 Russell Road
                          Paoli, Pennsylvania 19301
                          Attention:  Robert P. Donohue, Chief Financial Officer
                          Facsimile: (610)-251-2842

      10.6 INDEPENDENT CONTRACTORS. With respect to this Agreement, the parties
will be deemed independent contractors, and no party is, nor will be deemed to
be, an employee, agent, co-venturer, or legal representative of any other party
for any purpose. No party will be entitled to enter into any contracts in the
name of, or on behalf of, any other party, nor will any party be entitled to
pledge the credit of any other party in any way or hold itself out as having the
authority to do so.

      10.7 SEVERABILITY. If any provision of this Agreement is or becomes or is
deemed to be unenforceable under the laws or regulations of any country or other
jurisdiction in the Territory, then, as to such country or other jurisdiction:

            (a) Amendment. Such provision will be deemed, without further action
or signature required of either party hereto, to be automatically amended to
conform to the applicable laws of such jurisdiction so as to be valid and
enforceable, or, if it cannot be so amended without materially altering the
original intention of the parties, it will be stricken and a new provision will
be negotiated consistent with the purpose and intent of this Agreement;

                                                                            E-77
<PAGE>

            (b) No Impairment. The validity, legality and enforceability of such
provision will not in any way be affected or impaired thereby in any other
jurisdiction; and

            (c) Remainder of Agreement. The remainder of this Agreement will
remain in full force and effect.

      10.8 SURVIVAL. The provisions of Sections 5.2, 6.2, and 6.6 and of
Articles II (except for the licenses to Licensees, in the event of termination
of such licenses occurring as set forth in Section 6.6), IV (except for the
license to Licensor, in the event of termination of such license occurring as
set forth in Section 6.6), VII, VIII and X hereof will survive expiration or
termination, of this Agreement. The license rights granted in Articles II and IV
shall survive termination in accordance with Section 6.6.

      10.9 ASSIGNMENT. Neither Licensee may assign this Agreement or sublicense
or otherwise transfer any of its rights or obligations hereunder without the
prior written consent of Licensor, which consent may be withheld in Licensor's
sole discretion. Subject to the foregoing, this Agreement will inure to and be
binding upon the successors, legal representatives and permitted assigns of the
parties.

      10.10 NO WAIVER. No failure, delay, or single or partial exercise on the
part of either party in exercising any right hereunder will operate as a waiver
of, or impair, the exercise of any such right or any other right hereunder.

      10.11 ENTIRE AGREEMENT. This Agreement (together with all Schedules and
Exhibits hereto, if any, each of which is incorporated herein by reference)
constitutes the entire understanding between the parties with, respect to the
subject matter hereof and supersedes and replaces all prior discussions,
writings and agreements (oral or written) relating to the subject matter hereof.

      10.12 COUNTERPARTS. This Agreement may be executed in any number of
counterparts, each of which when so executed and delivered shall be deemed an
original, and all of such counterparts together shall constitute one and the
same instrument. Delivery of an executed counterpart of a signature page to this
Agreement by facsimile transmission shall be effective as delivery of a manually
executed counterpart of this Agreement.

      10.13 FORCE MAJEURE. No party will be liable to any other party for loss
or damage or will have any right to terminate this Agreement for any default or
delay attributable to any occurrence not within its control and which could not
have been avoided by commercially reasonable diligence, including, without
limitation, acts of God, acts of government, war, fire, flood, earthquake,
strike, labor dispute and other events beyond the reasonable control of such
party. The party affected shall give notice as promptly as is practicable of any
such cause to the other parties, and shall be excused from such of its
obligations hereunder (other than any cash payment obligations of a Licensee) as
it is thereby disabled from performing for so long as it is so disabled;
provided, however, that such affected party will commence and continue to take
reasonable and diligent actions to cure such default or delay.

                                                                            E-78
<PAGE>

      10.14 PRIOR DEVELOPMENT DISPUTES. In the event a prior development issue
arises with respect to rights under the Licensor's or MTF's respective future
patents as contemplated herein and one party desires to demonstrate or is
required to demonstrate with respect to a future patent right held by the other
party prior development occurring before a specified date and meeting or
exceeding the Prior Development Threshold, the following procedure shall be
used. The party asserting (a) that it has prior development occurring before a
specified date and meeting or exceeding the Prior Development Threshold and
entitling it to freedom of action as against a future patent of the other party
or (b) the party required to show prior development occurring before a specified
date and meeting or exceeding the Prior Development Threshold in order to assert
a future patent it owns, as applicable, shall present to the other party
documentary evidence demonstrating at least the following: that the prior
development work asserted to exist before the specified date includes the
following activities for the product(s) claimed to be the subject of prior
development:

            (a) a written description of design(s) or formulation(s)
constituting conception; and

            (b) defining clinical application(s) for said product(s); and

            (c) designing and making prototypes of said products(s); and

            (d) subjecting said prototypes to testing, for example, mechanical,
chemical, physical or biological testing

(such activities collectively comprising the "Prior Development Threshold"). The
activities shall be considered to meet or exceed the Prior Development Threshold
only if they have proceeded from the date of conception without any significant
period of abandonment.

      If the other party agrees, the parties shall create a memorandum
documenting the right of the party presenting the documentary evidence (A) to
have freedom of action as against a future patent of the other party or (B) to
assert a future patent it owns, as applicable, based on the demonstrated prior
development. If the parties do not agree on the prior development meeting or
exceeding the Prior Development Threshold, any dispute arising out of or
relating to such prior development issue shall be finally resolved by
arbitration. Either Licensor or MTF may initiate the arbitration process by
giving written notice to the other party. Such notice shall contain a statement
setting forth the patent rights affected and the nature of the priority claimed.
The arbitration shall be conducted in New York City in accordance with the
Commercial Arbitration Rules of the American Arbitration Association ("AAA") by
a suitable mutually agreed upon arbitrator with skill and knowledge in patents
and the relevant technology selected by the disputing parties from a panel
provided by the New York City office of the AAA, or if there is no agreed
arbitrator, then by a panel of three arbitrators selected by each party
selecting a single arbitrator with skill and knowledge in patents and the
relevant technology and these two selecting a third arbitrator with skill and
knowledge in patents and the relevant technology from a panel provided by the
New York City office of the AAA. The arbitrator(s) shall, where needed to
interpret the Prior Development Threshold standard, apply the substantive law of
priority of invention as it has been developed in interference cases before the
U.S. Patent and Trademark Office. The arbitral award shall be in writing and
shall be final and binding upon the parties, and

                                                                            E-79
<PAGE>

neither party shall appeal the award to any court or to the U.S. Patent and
Trademark Office. The parties shall each pay one-half (1/2) of the fee and costs
of the arbitrator(s), who shall not have the power to award the prevailing party
its attorneys' fees and related disbursements.

      10.15 LITIGATION OVER LICENSE SCOPE. In any action or proceeding to
interpret or enforce the terms of this Agreement that define the scope of the
licenses granted in Section 2.1 or Section 4.4 of this Agreement, the prevailing
party shall be entitled to recover its reasonable attorneys fees and costs from
the losing party or parties involved in such action or proceeding.

                  [Remainder of page intentionally left blank]

                                                                            E-80
<PAGE>

      IN WITNESS WHEREOF this Agreement has been duly executed by the duly
authorized representatives of the parties as of the date first above written.

                                   OSTEOTECH, INC.
                                   (LICENSOR)

                                   By:      /s/ Richard W. Bauer
                                      ------------------------------------------
                                   Title:   President and CEO
                                         ---------------------------------------

                                   MUSCULOSKELETAL TRANSPLANT FOUNDATION
                                  (a LICENSEE)

                                   By:     /s/ Bruce Stroever
                                      ------------------------------------------
                                   Title:  President/CEO
                                         ---------------------------------------

                                  BIOCON, INC.
                                  (a LICENSEE)

                                  By:    /s/ Bruce Stroever
                                     -------------------------------------------
                                  Title: President/CEO
                                        ----------------------------------------

                                  SYNTHES SPINE COMPANY, L.P.
                                  (a LICENSEE)

                                  By:    /s/ Thomas B. Higgins
                                     -------------------------------------------
                                  Title: President
                                        ----------------------------------------

                                                                            E-81
<PAGE>

                                                                    SCHEDULE 1.0
                                                            to License Agreement

Schedule 1.0 -- Osteotech Patents Excluded from License

Patent Number                         Date of Patent

    4,844,259                         July 4, 1989
    4,863,473                         September 5, 1989
    4,946,792                         August 7, 1990
    4,994,030                         February 19, 1991
    5,061,286                         October 29, 1991
    5,073,373                         December 17, 1991
    5,118,512                         June 2, 1992
    5,120,656                         June 9, 1992
    5,147,401                         September 15, 1992
    5,236,456                         August 17, 1993
    5,298,222                         March 29, 1994
    5,298,254                         March 29, 1994
    5,314,476                         May 24, 1994
    5,333,626                         August 2, 1994
    5,405,390                         April 11, 1995
    5,439,684                         August 8, 1995
    5,480,436                         January 2, 1996
    5,484,601                         January 16, 1996
    5,507,810                         April 16, 1996
    5,507,813                         April 16, 1996
    5,508,036                         April 16, 1996
    5,510,396                         April 23, 1996
    5,513,662                         May 7, 1996
    5,585,116                         December 17, 1996
    5,607,269                         March 4, 1997
    5,607,476                         March 4, 1997
    5,632,747                         May 27, 1997
    5,676,146                         October 14, 1997
    5,683,392                         November 4, 1997
    5,702,677                         December 30, 1997
    5,846,484                         December 8, 1998
    5,895,426                         April  20, 1999
    5,899,939                         May 4, 1999
    5,928,238                         July 27, 1999
    5,980,948                         November 9, 1999
    6,045,580                         April 4, 2000
    5676146 RE                        April 18, 2000
    6,123,731                         September 26, 2000
    6,162,258                         December 19, 2000
    6,277,149                         August 21, 2001
    6,294,041                         September 25, 2001
    6,294,187                         September 25, 2001
    6,315,795 B1                      November 13, 2001
    D450,240                          November 13, 2001
    6,332,779                         December 25, 2001
    6,368,322 B1                      April 9, 2002
    6,383,221 B1                      May 7, 2002

                                                                            E-82
<PAGE>

                                   EXHIBIT [A]
                              to License Agreement

                              PROCESSING AGREEMENT

         [See Exhibit 10.57 to the Quarterly Report on Form 10-Q for the quarter
ended June 30, 2002]

                                                                            E-83
<PAGE>

                                                                     EXHIBIT [B]
                         SETTLEMENT AGREEMENT               to License Agreement

         [See Exhibit 10.56 to the Quarterly Report on Form 10-Q for the quarter
ended June 30, 2002]

                                                                            E-84Exhibit 10.59

CAM Acquisition B.V.***
Zernikedreef 6
2333 CL Leiden
The Netherlands

Amsterdam, 10 July 2002

Dear Sirs,

On behalf of CAM IMPLANTS B.V., I hereby confirm that we agree with the transfer
of all rights and obligations in relation to:

(i)   Euro bank account number: 67.89.12.866 in the name of CAM IMPLANTS B.V.
      with ING Bank in Leiden; and

(ii)  US Dollar bank account number: 02.15.44.980 in the name of CAM IMPLANTS
      B.V. with ING Bank in Leiden;

to CAM Acquisition B.V. as of 1 July 2002.

The balance on the bank account as it was on 30 June 2002 at 24.00 hours, will
not be transferred to CAM Acquisition B.V.

Please return one original copy of this letter to us, after you have signed
below for approval.

Yours sincerely

CAM IMPLANTS B.V.

/s/ Michael John Jeffries
---------------------------------------
by: Michael John Jeffries
title: Director

Approved by:

CAM Acquisition B.V.

/s/ Gerard Anton Kok
---------------------------------------
on behalf of G.A. Kok Beheer B.V.
by: Gerard Anton Kok
title: Director of G.A. Kok Beheer B.V.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-85
<PAGE>

                            ASSET PURCHASE AGREEMENT
                                     between
                                CAM IMPLANTS B.V.
                                       and
                              CAM Acquisition B.V.
                                      dated
                                  10 July 2002

TABLE OF CONTENTS

A.    Asset Purchase Agreement

B.    Schedules

     1.   Schedule 1  Equipment
     2.   Schedule 2  Stock
     3.   Schedule 3  Intellectual Property Rights
     4.   Schedule 4  Receivables
     5.   Schedule 5  Permits
     6.   Schedule 6  The rights and obligations arising from the Contracts
     7.   Schedule 7  Liabilities accounted for in the Preliminary Balance Sheet
     8.   Schedule 8  Terms and conditions of employment by the Seller of all
                      employees
     9.   Schedule 9  Draft intellectual property transfer deed
     10.  Schedule 10 Draft Security Agreements
     11.  Schedule 11 Preliminary Balance Sheet
     12.  Schedule 12 Disclosure Letter
     13.  Schedule 13 Osteotech patents
     14.  Schedule 14 Draft deed of assignment of Osteotech patents
     15.  Schedule 15 Other Current Assets
     16.  Schedule 16 Resolution by the shareholder of CAM IMPLANTS B.V.
     17.  Schedule 17 Resignation letter by Gerard Anton Kok

C.    Intellectual property transfer deed

D.    Deed of assignment of Osteotech patents

E.    Security Agreements

     1.   Deed of pledge of equipment
     2.   Deed of pledge of stock
     3.   Deed of pledge of receivables
     4.   Deed of pledge of intellectual property rights

                                                                            E-86
<PAGE>

                            ASSET PURCHASE AGREEMENT

                                     between

                                CAM IMPLANTS B.V.
                                 (as the Seller)

                                       and

                              CAM Acquisition B.V.
                               (as the Purchaser)

                                                                            E-87
<PAGE>

CONTENTS

Clause 1    -   Definitions
Clause 2    -   Assets and Liabilities to be sold
Clause 3    -   Purchase Price
Clause 4    -   Transfer of the Assets and Liabilities
Clause 5    -   Payment and security
Clause 6    -   Determination of the Closing Balance Sheet
Clause 7    -   Obligations of the Seller
Clause 8    -   Obligations of the Purchaser
Clause 9    -   Notices
Clause 10   -   Confidentiality and non-competition
Clause 11   -   Miscellaneous

                                                                            E-88
<PAGE>

TABLE OF SCHEDULES TO THE AGREEMENT

Schedule 1  - Equipment
Schedule 2  - Stock
Schedule 3  - Intellectual Property Rights
Schedule 4  - Receivables
Schedule 5  - Permits
Schedule 6  - The rights and obligations arising from the Contracts
Schedule 7  - Liabilities accounted for in the Preliminary Balance Sheet
Schedule 8  - Terms and conditions of employment by the Seller of all employees
Schedule 9  - Draft intellectual property transfer deed
Schedule 10 - Draft Security Agreements
Schedule 11 - Preliminary Balance Sheet
Schedule 12 - Disclosure Letter
Schedule 13 - Osteotech patents
Schedule 14 - Osteotech draft deed of assignment
Schedule 15 - Other Current Assets
Schedule 16 - Resolution by the shareholder of CAM IMPLANTS B.V.
Schedule 17 - Resignation letter by Gerard Anton Kok

                                                                            E-89
<PAGE>

                           ASSET PURCHASE AGREEMENT

THE UNDERSIGNED:

1.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries,
      (the "Seller");

and

2.    CAM Acquisition B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered office in and with its principal
      office at Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly
      represented by Gerard Anton Kok on behalf of G.A. Kok Beheer B.V., (the
      "Purchaser");

WHEREAS:

A.    The Seller carries on the business of conducting scientific research in
      the field of health care, particularly of biomedical products, the
      development of technologies for the production of biomedical products, the
      production, sale and purchase of materials in the field of health care,
      carried on, at or from its premises under the trade name CAM IMPLANTS B.V.
      (the "Business");

B.    Gerard Anton Kok is managing director of CAM IMPLANTS B.V. since 1 April
      1998, in which capacity he is responsible for the business and activities
      (as referred to under A above) carried on by CAM IMPLANTS B.V.;

C.    The Purchaser has decided to purchase certain of the Assets and
      Liabilities from the Seller and the Seller has decided to sell certain of
      the Assets and Liabilities to the Purchaser on the terms and conditions of
      this Agreement;

D.    The sole shareholder of the Seller has approved the sale of certain of its
      Assets and Liabilities by means of an appropriate resolution in writing. A
      copy of such resolution is attached to this Agreement as Schedule 16;

E.    On the Closing Date, after the Seller and the Purchaser have entered into
      this Agreement, Osteotech, Inc. will assign the patents as specified in
      Schedule 13 to this Agreement to the Purchaser, by means of the execution
      of the deed of assignment in the form attached to this Agreement as
      Schedule 14.

                                                                            E-90
<PAGE>

HAVE AGREED AS FOLLOWS:

Clause 1 - Definitions

1.1   In this Agreement, including all Schedules thereto, the following terms
      have the meaning set forth hereafter:

      "Additional Amount"               The additional amount referred to in
                                        clause 3 of this Agreement;

      "Agreement"                       the present agreement of sale and
                                        purchase of the Assets and Liabilities,
                                        including all Schedules thereto;

      "Annual Accounts ***"             the annual accounts of the Purchaser for
                                        the financial year ending on ***which
                                        will be drawn up in accordance with
                                        Dutch GAAP and as consistent with the
                                        policies and conventions applied in the
                                        Closing Balance Sheet;

      "Annual Accounts ***"             the annual accounts of the Purchaser for
                                        the financial year ending on ***which
                                        will be drawn up in accordance with
                                        Dutch GAAP and as consistent with the
                                        policies and conventions applied in the
                                        Closing Balance Sheet;

      "Assets"                          the assets referred to in clause 2.1
                                        through clause 2.4;

      "BW"                              Dutch Civil Code (Burgerlijk Wetboek);

      "Business"                        the business carried on by the Seller as
                                        referred to under A of the preamble of
                                        this Agreement;

      "Change of Control"               the sale and transfer by the Purchaser
                                        of at least 50% of: (i) its outstanding
                                        share capital, or (ii) the Assets,
                                        Liabilities and Business, to any other
                                        third party than Klaas de Groot as a
                                        private individual or a legal entity in
                                        which Klaas de Groot is directly or
                                        indirectly the sole shareholder;

      "Closing Balance Sheet"           the final survey of the Assets and
                                        Liabilities as at Effective Date, to be
                                        determined by the Seller and the
                                        Purchaser, in accordance with clause 6
                                        of this Agreement;

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-91
<PAGE>

      "Closing Date"                    the date, mutually agreed between the
                                        Parties, on which Parties enter into
                                        this Agreement and the Assets and
                                        Liabilities will be transferred from the
                                        Seller to the Purchaser;

      "Consent"                         a consent of a relevant authority
                                        necessary to authorize, approve or
                                        permit the full and complete transfers
                                        of the Permits as contemplated by this
                                        Agreement;

      "Contracts"                       the contracts specified in Schedule 6;

      "Disclosure Letter"               the letter from Gerard Anton Kok as
                                        managing director of CAM IMPLANTS B.V.
                                        to the Seller, dated on the Closing Date
                                        and attached to this Agreement as
                                        Schedule 12, which contains all
                                        liabilities, including the inter-company
                                        liabilities between the Seller and any
                                        other Group Company, that will be
                                        excluded from the sale and transfer
                                        contemplated by this Agreement;

      "Dutch GAAP"                      Dutch Generally Accepted Accounting
                                        Principles;

      "Effective Date"                  30 June 2002;

      "Equipment"                       the equipment, inventory (inventaris)
                                        and other movable assets excluding the
                                        Stock, as specified in Schedule 1;

      "Group Company"                   Osteotech, Inc., a company incorporated
                                        under the laws of the State of New
                                        Jersey, United States of America, and
                                        all companies or enterprises directly or
                                        indirectly owned by it, including,
                                        amongst others: Osteotech B.V., HC
                                        Implants B.V., Osteotech/CAM Services
                                        B.V. and CAM IMPLANTS B.V.;

      "Intellectual Property Rights"    including without limitation all
                                        trademarks, patents, trademarks, service
                                        marks, registered design rights,
                                        including any applications for any of
                                        the foregoing, trade and business names,
                                        service marks, logos, copyrights, rights
                                        in design invention, rights under
                                        licenses and rights of the same or
                                        similar nature in any part of the world
                                        relative to the Business, together with
                                        all know-how, being all information not
                                        present in the public domain owned by
                                        the Seller or used by the Seller in, or
                                        in connection with the Business held in
                                        any form (including drawings, data,
                                        formulae, specifications, component
                                        lists, instructions, manuals, brochures
                                        and catalogues) and, among

                                                                            E-92
<PAGE>

                                        other things and without limitation,
                                        relating to the manufacture or
                                        production of goods or the provision of
                                        services, all as specified in Schedule
                                        3;

      "Liabilities"                     the liabilities, debts and obligations
                                        referred to in clause 2.5;

      "Material Event of Default"       any material event of default from the
                                        Purchaser in the fulfillment of its
                                        obligations under this Agreement;

      "Other Current Assets"            the prepaid expenses and other current
                                        assets, as specified in Schedule 15;

      "Parties"                         the Purchaser and the Seller;

      "Permit"                          any permit, licence, consent,
                                        authorization and similar approval and
                                        exemption, including conditions attached
                                        thereto, which is required under any
                                        law, regulation or rule in order to
                                        carry on the Business, as specified in
                                        Schedule 5;

      "Preliminary Balance Sheet"       the preliminary survey of the Assets and
                                        Liabilities as at 31 March 2002, as
                                        specified in Schedule 11, determined and
                                        signed for approval by the Parties;

      "Purchaser"                       CAM Acquisition B.V.;

      "Purchase Price"                  the purchase price referred to in clause
                                        3 of this Agreement;

      "Receivables"                     the trade account receivables resulting
                                        from the invoice of products and
                                        services in the ordinary course of
                                        business, as specified in Schedule 4;

      "Schedule"                        a schedule to this Agreement;

      "Security Agreements"             the draft deeds of pledge of equipment,
                                        stock, receivables and intellectual
                                        property rights as set out in Schedule
                                        10;

      "Seller"                          CAM IMPLANTS B.V.;

      "Stock"                           the stock (voorraden) as specified in
                                        Schedule 2;

1.2   In this Agreement, unless otherwise specified:

      (a)   references to statutory provisions are to statutory provisions which
            are in force at the Closing Date;

      (b)   words denoting the singular include the plural and vice versa,
            except where the context requires otherwise.

                                                                            E-93
<PAGE>

1.3   Headings to clauses are for convenience only and do not affect the
      interpretation of this Agreement.

Clause 2 - Assets and Liabilities to be sold

2.1   The Seller as legal and beneficial owner (juridische en economische
      eigenaar) hereby sells and the Purchaser hereby purchases the Assets
      accounted for in the Preliminary Balance Sheet as described in clause 2.3
      and the Assets not accounted for in the Preliminary Balance Sheet as
      described in clause 2.4.

2.2   Upon agreement between the Parties with regard to the determination of the
      Closing Balance Sheet pursuant to clause 6.2 and clause 6.3 of this
      Agreement, the Closing Balance Sheet will replace the Preliminary Balance
      Sheet. Upon such replacement of Preliminary Balance Sheet by the Closing
      Balance Sheet, the Schedules 1 through 8 and Schedule 15 will be replaced
      in accordance with the Closing Balance Sheet and the state of the Assets
      and the Liabilities as of the Effective Date.

2.3   The Assets accounted for in the Preliminary Balance Sheet (and to be
      accounted for in the Closing Balance Sheet) are:

      (a)   the Equipment, which is either on the premises of the Seller or
            being used by the employees of the Seller, as far as they are owned
            by the Seller, all as specified in Schedule 1;

      (b)   the Stock, as specified in Schedule 2;

      (c)   the Intellectual Property Rights, as specified in Schedule 3;

      (d)   the Receivables (including amounts that still need to be invoiced),
            as specified in Schedule 4, but expressly excluding any and all
            inter-company receivables between the Seller, and any other Group
            Company;

      (e)   the Other Current Assets, as specified in Schedule 15.

      The Assets accounted for in the Preliminary Balance Sheet (and to be
      accounted for in the Closing Balance Sheet), which have neither been
      stated in this clause 2.3 nor in Schedules 1, 2, 3, 4 and Schedule 15 to
      this Agreement, will not be sold or transferred by the Seller to the
      Purchaser. Any cash in hand, balances on bank and giro accounts, bills of
      exchange and cheques are expressly excluded from this Agreement and will
      not be sold or transferred by the Seller to the Purchaser. Any fiscal net
      operating loss carry forwards (compensabele verliezen) are expressly
      excluded from this Agreement and will not be sold or transferred by the
      Seller to the Purchaser.

2.4   The Assets that have not been accounted for in the Preliminary Balance
      Sheet (and will not be accounted for in the Closing Balance Sheet) are:

      (a)   the books and accounts, customer files and data storage media,
            documents and data relating to the Business;

                                                                            E-94
<PAGE>

      (b)   the Permits granted to the Seller, as specified in Schedule 5;

      (c)   the rights arising from the Contracts, as specified in Schedule 6.

2.5   The Purchaser hereby also assumes from the Seller the Liabilities,
      consisting of:

      (a)   The liabilities accounted for in the Preliminary Balance Sheet (and
            to be accounted for in the Closing Balance Sheet), including the
            obligations towards the creditors, as specified in Schedule 7, but
            expressly excluding any and all intercompany liabilities between the
            Seller and any other Group Company;

      (b)   the obligations of the Seller arising from the Contracts, as
            specified in Schedule 6;

      (c)   the obligations of the Seller arising from the employment contracts,
            as specified in Schedule 8;

      (d)   all other liabilities attaching to the Assets as referred to in
            clause 2.3 and clause 2.4 above (other than those referred to under
            sub-clauses a, b and c above), and

      (e)   all other liabilities of the Seller in connection with the Business
            to be transferred under this Agreement to the Purchaser, which, in
            accordance with Dutch GAAP, should have been accounted for in the
            Preliminary Balance Sheet, but were excluded by Gerard Anton Kok as
            managing director of CAM IMPLANTS B.V. for whatever reason and which
            were not expressly excluded from this Agreement in the Disclosure
            Letter.

2.6   The sale and purchase of the Assets and Liabilities is effective as of the
      Effective Date.

2.7   The sale and purchase of the Assets and Liabilities of the Seller is the
      transfer of an enterprise within the meaning of sections 662 et seq. of
      book 7 BW, with the result that the rights and obligations of the Seller
      arising from the employment contracts with its employees shall be
      transferred to the Purchaser by operation of law.

Clause 3 - Purchase Price

3.1   The Purchase Price for the Assets and Liabilities amounts to USD 2,500,000
      (say two and a half million US Dollars). In determining the Purchase
      Price, the Parties have assumed that section 31 of the Value Added Tax Act
      (Wet op de Omzetbelasting) is applicable. If, notwithstanding the
      foregoing, the tax authorities levy value added tax on the sale and
      purchase of the Assets and Liabilities, the due amount of the value added
      tax shall be added to the Purchase Price, provided the Seller will make
      available an appropriate invoice to the Purchaser in due form. An
      Additional Amount of ***(***) will be paid by the Purchaser to the Seller
      in two instalments: (i) ***will be paid if the revenue of the

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-95
<PAGE>

      Purchaser in the year ending *** exceeds ***, and (ii) *** will be paid if
      the revenue of the Purchaser in the year ending *** exceeds ***.

3.2   Subject to clause 3.5, the Purchase Price shall be due and payable by the
      Purchaser to the Seller as follows:

      (a)   USD 1 million at the Closing Date;

      (b)   USD 250,000 in the year 2003, to be paid at the last day of each
            calendar quarter in four equal instalments of USD 62,500;

      (c)   USD 325,000 in the year 2004, to be paid at the last day of each
            calendar quarter in four equal instalments of USD 81,250;

      (d)   USD 425,000 in the year 2005, to be paid at the last day of each
            calendar quarter in four equal instalments of USD 106,250;

      (e)   USD 500,000 in the year 2006, to be paid at the last day of each
            calendar quarter in four equal instalments of USD 125,000;

      (f)   In the event of late payment by the Purchaser, the amounts due will
            be increased by statutory interest (wettelijke rente).

3.3   The Additional Amount shall be due and payable by the Purchaser to the
      Seller as follows:

      (a)   ***, if, according to the Annual Accounts *** the total revenue of
            the Purchaser exceeds the amount of ***, to be paid no later than
            ***;

      (b)   ***, if, according to the Annual Accounts *** the total revenue of
            the Purchaser exceeds the amount of ***, to be paid no later than
            ***;

      (c)   In the event of late payment by the Purchaser, the amounts due will
            be increased by statutory interest.

3.4   Upon the occurrence of a Change of Control, the Purchase Price and the
      Additional Amount shall be immediately due and payable by the Purchaser to
      the Seller, unless the Purchaser obtains written consent from the Seller
      prior to such Change of Control.

3.5   Prior to the signing of this Agreement, the Purchaser has paid the amount
      of the Purchase Price as specified in clause 3.2 (a), by means of a
      telephonic transfer to bank account number 47.47.94.032 with ABN Amro Bank
      N.V. in the name of Stibbe Derdengelden Notariaat (reference: 176880),
      Swift Code ABNANL2A.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                            E-96
<PAGE>

3.6   The payments stated under clause 3.2 (b) through clause 3.2 (e) are due
      and payable by the Purchaser to the Seller subject to the condition
      precedent that the Seller and all other Group Companies have fulfilled
      their obligation to accomplish all formalities (legal and otherwise)
      required on their behalf for a legally valid transfer of the full and
      unencumbered legal and beneficial ownership of the Assets as purchased by
      the Purchaser under this Agreement.

Clause 4 - Transfer of the Assets and Liabilities

4.1   On the Closing Date the transfer of the Assets and Liabilities shall take
      place in the following manner:

      (a)   the Intellectual Property Rights shall be transferred by means of a
            deed of transfer in the form of Schedule 9;

      (b)   all rights and obligations (het geheel aan rechtsverhoudingen)
            arising from the Contracts shall be assigned by the Seller to the
            Purchaser and acquired and assumed by the Purchaser by means of
            signing this Agreement. Within one week from the Closing Date, the
            Parties shall also give joint written notice of the assignment to
            the other parties to the Contracts who have given prior consent to
            the assignment. In the event and to the extent that the other
            parties to the Contracts have not granted prior consent to the
            assignment, the Parties shall give joint written notice of the
            assignment to these other parties within one week from the Closing
            Date and use their best efforts to obtain such parties' cooperation;

      (c)   the Assets that have not been mentioned under 4.1(a) or 4.1(b), as
            far as they are not held by third parties, shall be transferred by
            the signing of this Agreement by the Parties and by (i) giving the
            Purchaser access to the spaces in which the Assets are located, (ii)
            by the delivery of the keys, (iii) by the delivery of ownership
            documents (eigendomsbewijzen), (iv) with respect to the Permits by
            sending written notice to the authorities concerned and (v) with
            respect to the Receivables, by written notice by the joint Parties
            to the debtors concerned within one week from the Closing Date;

      (d)   the Assets that have not been mentioned under 4.1(a) or 4.1(b), as
            far as they are held by third parties, shall be transferred by the
            signing of this Agreement by the Parties and by giving notice of the
            transfer to the third party concerned. Such notice shall be given by
            the joint Parties within one week from the Closing Date;

      (e)   the Liabilities of which the transfer has already been approved by
            the creditors under these Liabilities beforehand, will be
            transferred by the signing of this Agreement by the Parties and
            through a written notice given by the joint Parties to the said
            creditors within one week from the Closing Date. In the event and to
            the extent that the creditors under certain Liabilities have not
            granted prior consent to the transfer of these Liabilities, the
            Parties shall, after signing this Agreement, send written notice of
            the intended transfer to the said creditors within one week

                                                                            E-97
<PAGE>

            from the Closing Date and use their best efforts to obtain their
            approval of the transfer.

4.2   On the Closing Date the following acts will be performed and the following
      agreements will be signed in the order as given below:

      (a)   the Purchaser shall pay the amount due as referred to in clause 3.2
            (a);

      (b)   the Parties shall sign this Agreement;

      (c)   the Parties shall sign the Security Agreements as referred to in
            clause 5.2.

4.3   The Seller shall undertake all actions that the Purchaser reasonably deems
      necessary in connection with the transfer of the Assets and Liabilities to
      the Purchaser. The Seller shall sign all documents that it is reasonably
      requested to sign by the Purchaser in connection with the transfer of one
      or more of the Assets and/or Liabilities.

4.4   As long as practicable after signing this Agreement, the Purchaser and the
      Seller shall jointly do all acts and sign such deeds as is reasonably
      necessary to obtain all required Consents. If any such Consent is not
      obtained, the Seller will cooperate with the Purchaser in any reasonable
      arrangement to provide the Purchaser with the economic benefits that it
      would have obtained if the relevant Consent had been obtained.

4.5   If the assignment of one or more of the Contracts to (contractsoverneming
      door) the Purchaser has not taken place in accordance with clause 4.1
      above within two months as from the Closing Date (whether this is due to a
      lack of cooperation by the other party or parties to these Contracts or
      for any other reason) the Seller shall, provided it is legally entitled to
      do so, as soon as practicable transfer the rights arising from the
      Contract(s) concerned to the Purchaser and the Purchaser shall fulfil the
      obligations arising from the Contract(s) concerned in the Seller's name,
      but for the Purchaser's own account. In this manner the said rights will
      be exercised for the benefit of the Purchaser and the said obligations
      will be fulfilled for the Purchaser's account, as if the Contracts
      concerned had been assigned under clause 4.1 above. Under the condition
      precedent (opschortende voorwaarde) that the Seller does not transfer the
      said rights to the Purchaser after the expiry of the above-mentioned two
      month period or that it is not legally entitled to transfer the above
      rights, the Purchaser is hereby granted a power of attorney (een volmacht)
      to exercise these rights in the Seller's name but for the Purchaser's
      account.

Clause 5 - Payment and security

5.1   Prior to the signing of this Agreement the Purchaser shall pay the
      Purchase Price in part (as specified in clause 3.2 (a)) by means of a
      telephonic transfer by the Purchaser to bank account number 47.47.94.032
      with the ABN Amro Bank N.V. in the name of Stibbe Derdengelden Notariaat
      (reference: 176880), Swift Code ABNANL2A.

5.2   As security for its payment obligations under clauses 3.2 and 3.3, the
      Purchaser shall grant to the benefit of the Seller on the Closing Date,
      security interests over all its assets by entering into the Security
      Agreements in the form attached to this Agreement as

                                                                            E-98
<PAGE>

      Schedule 10. These security interests will be subordinated in ranking to
      any security interests that will be granted by the Purchaser to its bank
      in order to finance the ongoing Business as of the Closing Date.

5.3   As security for its payment obligations under clauses 3.2 and 3.3, the
      Purchaser shall grant to the benefit of the Seller within one week after
      the Closing Date, a second right of mortgage over the perpetual ground
      lease of the land owned by the Municipality of Leiden, with the right of
      the leaseholder of the building constructed thereon, locally known as
      Zernikedreef 6, Leiden, known at the Land Registry Office as Municipality
      Leiden section X number 4003, measuring 28 are and 40 centiare. This
      security interest will be subordinated in ranking to the mortgage that has
      been granted by the Purchaser to ING Bank N.V. in order to finance the
      acquisition of the ground lease as described in this clause. This clause
      5.3 has been agreed upon between the Parties on the condition precedent
      that ING Bank N.V. approves the granting by the Purchaser of the
      above-mentioned second right of mortgage. In the event that the Purchaser
      has not granted the above-mentioned second right of mortgage for the
      benefit of the Seller within one month after the Closing Date, the
      Purchase Price and the Additional Amount shall be immediately due and
      payable by the Purchaser to the Seller, unless the Purchaser obtains
      written consent from the Seller for such delay. In the event that the
      Purchaser is desirous to sell the ground lease as described in this clause
      to any third party, the Seller shall release the Purchaser for the
      above-mentioned second right of mortgage, unless the Purchaser has not
      fulfilled its payment obligations pursuant to clause 3.1 through clause
      3.4 of this Agreement.

Clause 6 - Determination of the Closing Balance Sheet

6.1   The Parties have drawn up the Preliminary Balance Sheet as specified in
      Schedule 11. The Preliminary Balance Sheet has been drawn up in accordance
      with Dutch GAAP and as consistent with the policies and conventions
      applied by the Seller in the financial year 2001. Both Parties have signed
      the Preliminary Balance Sheet for approval. The Purchaser shall draw up
      the Closing Balance Sheet. The Closing Balance Sheet will be the balance
      sheet as at the Effective Date. The Closing Balance Sheet will be
      delivered to the Seller not later than 31 July 2002, and will be drawn up
      in accordance with Dutch GAAP and as consistent with the policies and
      conventions applied by the Seller in the financial year 2001.

6.2   After delivery of the Closing Balance Sheet to the Seller, the Seller may
      audit the Closing Balance Sheet for a period of fifteen days. The
      Purchaser shall fully cooperate with this audit, including the provision
      of all explanations and the delivery of any documents reasonably desired
      by the Seller. If the Seller gives notice of its non-approval of the
      Closing Balance Sheet within the said period of fifteen days, the Parties
      shall use their best efforts to reach an agreement with respect to the
      Closing Balance Sheet. If the Parties reach an agreement with respect to
      the desired adjustments in the Closing Balance Sheet, the adjusted Closing
      Balance Sheet shall replace the original Closing Balance Sheet that has
      been drawn up by the Purchaser.

                                                                            E-99
<PAGE>

6.3   If the Parties cannot reach an agreement with respect to the Closing
      Balance Sheet pursuant to the provisions of clause 6.2, each of the
      Parties shall be entitled to apply to the President of the Netherlands
      Institute of Registeraccountants (NIVRA) with the request to appoint an
      independent expert to settle the dispute regarding the Closing Balance
      Sheet. Any decision by the independent expert shall be incorporated in the
      Closing Balance Sheet, which shall then be deemed to be approved by the
      Seller and the Purchaser. The expert's costs shall be shared equally
      between the Parties, unless the expert decides otherwise, whether at the
      request of one of the Parties or on his own initiative.

Clause 7 - Obligations of the Seller

7.1   The Seller shall change its address so that it is no longer registered at
      the address Zernikedreef 6, 2333 CL, Leiden, the Netherlands, as soon as
      possible and by no later than three months after the Closing Date.

7.2   the Seller procures that its sole shareholder, HC Implants B.V., shall
      discharge Gerard Anton Kok in respect of the fulfillment of his tasks as
      managing director of the Seller until the Closing Date.

Clause 8 - Obligations of the Purchaser

8.1   Prior to, or ultimately on the Closing Date, Gerard Anton Kok shall
      deliver a letter to the Seller in which he:

      (a)   resigns as member of the management board of the Seller on the
            Closing Date prior to the signing of this Agreement;

      (b)   states that he will waive any claims that he will have in the future
            in connection with the performance of his duties as managing
            director of the Seller.

      A copy of this letter is attached to this Agreement as Schedule 17.

8.2   The Purchaser will use its best efforts to:

      (a)   cooperate with the Seller and any of the other Group Companies to
            make available on a timely basis whatever records and/or assistance
            that may be necessary to file any application for tax return for the
            benefit of the Seller for the years 2001 and 2002 with the tax
            authorities, and

      (b)   cooperate with the Seller and any of the other Group Companies to
            make available on a timely basis whatever records and/or assistance
            that may be necessary to file the annual accounts or any other
            report that has to be filed by the Seller pursuant to the laws of
            the Netherlands for the years 2001 and 2002.

Clause 9 - Notices

                                                                           E-100
<PAGE>

Any notice required to be delivered to the Parties pursuant to this Agreement
shall be in writing and sent by regular mail and telefax to the addresses set
forth below:

To the Purchaser:
Name                           CAM Acquisition B.V
Address                        Zernikedreef 6, 2333 CL, Leiden, the Netherlands
For the attention of           Gerard Anton Kok
Telephone/telefax              +31 71 524 06 24/+31 71 524 06 96

To the Seller
Name:                          Osteotech, Inc.
Address                        51 James Way, Eatontown, New Jersey, 07724,
                               United States of America
For the attention of           Michael John Jeffries
Telephone / telefax            +1 732 544 6205/+1 732 935 0626

or to such other address or representative as a Party may notify the other Party
of in the manner set forth above. A copy of every notice shall be sent at the
same time to the fax number of the other Party. A statement which does not
comply with this clause shall have no effect. This clause shall also apply to
notices given in connection with agreements which are connected with this
Agreement, unless the relevant agreement expressly provides otherwise.

Clause 10 - Confidentiality and non-competition

10.1  The Seller undertakes that none of the Group Companies shall provide to
      any third party any information that has come to its knowledge regarding:
      (i) the Business, or (ii) the Purchaser, or (iii) any of the Purchaser's
      subsidiaries or participations, or (iv) the rights and obligations arising
      from the Contracts as specified in Schedule 6, of which the Seller knows
      or should have known that it is of a confidential nature, unless the
      Seller is allowed to do so pursuant to the Security Agreements as
      specified in Schedule 10, or is required to do so by law or the
      regulations of the SEC or by any applicable stock exchange regulation.

10.2  None of the Parties shall, without the prior written consent of the other
      Party, inform any person about the contents of this Agreement or any of
      the transactions effectuated pursuant to this Agreement, unless any of the
      Parties is required to do so by law or the regulations of the SEC or by
      any applicable stock exchange regulation.

10.3  All publicity with respect to this Agreement, internally as well as
      externally, shall be agreed upon between the Parties, with respect to the
      contents as well as with regard to the form and the time of the
      publication, unless any of the Parties is required by law or the
      regulations of the SEC or by any applicable stock exchange regulation to
      do such publication(s).

                                                                           E-101
<PAGE>

10.4  Unless a Material Event of Default has occurred, the Seller undertakes
      that none of the Group Companies shall, without the prior written consent
      of the Purchaser, for a period of five years after the Closing Date in any
      region of the world, either directly or indirectly:

      (a)   conduct an enterprise, in whatever form, equal or comparable to that
            of the Business at the Closing Date excluding the development,
            production, marketing, sale and distribution of human tissue
            material or products containing human tissue material, also if mixed
            with any bio-materials;

      (b)   have a financial interest in such an enterprise, in whatever form,
            or have a share or other interests in it, whether potential or not,
            with the exception of shares in a company listed on the stock
            exchange not exceeding a percentage of [ten] percent;

      (c)   aid or assist such an enterprise in whatever form, with or without
            compensation;

      (d)   engage or procure third parties to engage in any form of commercial
            or other activities, equal or comparable to those of the Business at
            the Closing Date.

Clause 11 - Miscellaneous

11.1  The Purchaser agrees for a period of 3 years, to sell under normal
      business conditions, and if available in the ordinary course of business,
      to the Seller, at its request, calcium phosphate and calcium phosphate
      products at prices no less favourable then the best price offered to
      comparable customers of the Purchaser for such quantities.

11.2  Within one month after the Closing Date, the Seller shall change its
      articles of association and rename the company in order to delete the
      words "CAM IMPLANTS", or dissolve the company. After signing of the
      Agreement, the Group Companies shall in any event no longer be authorised
      to use the trade name "CAM IMPLANTS". As of the Closing Date the Purchaser
      will be authorised to use the trade name "CAM IMPLANTS".

11.3  This Agreement contains the entire Agreement between the Parties with
      respect to the sale and purchase of the Assets and Liabilities and this
      Agreement supersedes all earlier agreements, either verbally or in
      writing, between the Parties.

11.4  The Schedules to this Agreement form an integral part of this Agreement.
      Any references to this Agreement include a reference to the aforesaid
      Schedules and vice versa.

11.5  This Agreement can only be amended by a written agreement of the Parties.

11.6  At the request of the Purchaser, the Seller shall sign all documents and
      execute all other instruments and undertake and perform all acts necessary
      for the fulfilment of its obligations arising from this Agreement.

11.7  Each of the Parties shall bear its own costs and expenses made or incurred
      with respect to this Agreement.

                                                                           E-102
<PAGE>

11.8  If any provision of this Agreement should be invalid or in any other way
      unenforceable, such provision shall be ineffective only to the extent of
      such unenforceability or invalidity and shall in no way affect the
      enforceability or validity of the remainder of such provision nor of the
      other provisions of this Agreement. In such event the Parties shall after
      mutual consultation amend such provision insofar as necessary and replace
      the provision that is invalid or unenforceable by a provision that
      resembles the invalid or unenforceable provision as closely as possible.

11.9  The Parties explicitly waive all their rights to rescind (ontbinden) or
      avoid (vernietigen) this Agreement after the Closing Date, except for
      their right to invoke section 44 of book 3 BW (in the highly unlikely
      event that this would be necessary). The Parties also explicitly waive
      their right to invoke section 258 of book 6 BW after the Closing Date.

11.10 The Seller may transfer its rights and obligations jointly under this
      Agreement, to one of its subsidiaries or participations and/or procure
      that one of its subsidiaries or participations substitute(s) the Seller as
      a Party to this Agreement.

11.11 This Agreement and the rights and obligations arising from it shall be
      governed by and construed in accordance with the laws of the Netherlands.

11.12 All disputes arising out of or in connection with this Agreement and/or
      any agreement arising out of the same, shall -- unless any imperative rule
      of law dictates otherwise -- be settled with the exclusion of all other
      judicial authorities by the (President of the) District Court in
      Amsterdam, without prejudice to the right of appeal and that of appeal to
      the Supreme Court.

THUS AGREED AND EXECUTED IN TWO ORIGINAL COPIES IN AMSTERDAM ON 10 JULY 2002:

--------------------------------         -------------------------------
CAM IMPLANTS B.V.                        CAM Acquisition B.V.

by: Michael John Jeffries                on behalf of G.A. Kok Beheer B.V.

title: Director                          by: Gerard Anton Kok

                                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-103
<PAGE>

SCHEDULE 1 - EQUIPMENT

             Date Acquired                   Description
             -------------                   -----------

             Computers

             01-07-88                        Zenith Computer
             01-01-89                        Computer
             01-03-89                        Printer
             01-05-89                        Computer software
             10-01-91                        Laser Computer AT3
             27-04-92                        Mega Shitec Comp
             12-01-93                        Amstrad
             15-10-91                        Label printer
             20-02-92                        Harvard Graphics
             21-02-92                        Icon 386-40Mhz
             18-01-93                        HP Laserjet printer
             05-05-94                        Compac
             26-08-94                        Compac
             17-02-95                        Compac
             01-07-88                        Laser XT Computer
             01-07-88                        Laser AT Computer
             01-07-88                        Software
             01-07-88                        Laser Printer
             01-09-89                        Brunet software
             11-01-90                        Nec Pinwriter P6+
             07-07-91                        Comp+Print+Software
             10-03-92                        Laser Comp. 386 SXE
             16-06-92                        Icon Computer
             12-08-92                        Monitor+Keybord
             01-09-92                        Nec Pinwriter P7
             29-10-92                        Amstrad Computer
             20-01-93                        HP LaserJet printer
             19-05-93                        Compaq Deskpro
             08-09-93                        Compac
             01-12-93                        Compac
             02-03-94                        Compac Deskpro 386S
             17-06-94                        MS Works+Windows
             09-08-94                        Lantastic Netwerk
             05-08-94                        Compac
             29-08-94                        Grote Beer Netwerk
             10-09-94                        ATS/Lantastic
             06-09-94                        lnmac/Dataperfect
             06-09-94                        ATS/Articom Software
             03-01-95                        ATS/Server+toebeh.
             17-02-95                        ATS/2xCompac
             17-03-95                        Inmac/Epson printer

                                                                           E-104
<PAGE>

             Date Acquired                 Description
             -------------                 -----------

             Computers (continued)

             10-05-95                      Etherlink+Adapter
             19-05-95                      Adv.Ethernet 12 port
             19-05-95                      Compaq k1. monitor
             31-05-95                      10 users lantastic
             08-08-95                      Etherlink III
             03-05-96                      Update Eticad
             11-07-91                      Laser Computer
             06-12-90                      Printer
             01-01-89                      Computer
             11-02-91                      Computer LT3230
             30-01-92                      Printer
             23-11-92                      Memo Pocket
             08-01-93                      Amstrad
             26-02-93                      Mini Tower
             29-04-94                      Compaq
             16-05-95                      Brother Laserprinter
             07-07-95                      Assy.Interface Dual
             01-05-88                      Computer+ Printer
             01-05-93                      ATS/Compaq+Monitor
             17-09-93                      INMAC/Epson printer
             12-11-93                      ATS/Compaq+Monitor
             31-08-94                      lnmac/Laserprinter
             24-01-95                      Computer Lok + softw
             30-01-95                      Computer Kl.Kast
             01-05-95                      Compac computer
             09-05-95                      ATS/Computers
             19-05-95                      Batterijvoeder
             03-09-95                      3 Pentiums
             03-03-96                      Gateway comp.(WD)
             02-05-96                      Scanjet+Laserjets
             28-05-96                      Multipay
             31-03-96                      PS/Ross/Nw system
             07-08-96                      Statgraphics plus
             03-03-97                      Printer G.N.
             17-04-97                      Matlab
             23-04-97                      Backup-systeem
             12-09-97                      CD-Rom software
             01-07-97                      Laptop G.N.
             20-10-97                      Prened apparatuur
             29-05-98                      Business Objects
             22-06-98                      Laserjet HP

                                                                           E-105
<PAGE>

             Date Acquired                 Description
             -------------                 -----------

             Computers (continued)

             17-07-98                      Gateway computers
             28-09-98                      App.+Progr.+Oracle
             05-10-98                      Aansl.Kleurenprinter
             16-10-98                      Datamonitor/CD-roms
             17-11-98                      Ross/Apparatuur+Prog
             11-12-98                      Wingate Pro 10
             06-07-99                      NTS/Printers
             03-08-99                      Gateway/Computers
             09-09-99                      OASIS/Software
             28-09-99                      Ross/Uitbreiding
             30-09-99                      Speed CD-Writer
             28-10-99                      Laptop
             31-12-99                      MS Office
             26-01-00                      Notebook
             01-02-00                      Gateway Computers
             29-02-00                      Faxmodem
             10-03-00                      Cartridges
             14-03-00                      Software Labelpr.
             24-03-00                      Matlab software
             27-03-00                      Upgrade Markets
             28-04-00                      Eprom Software
             18-01-01                      Digitale camera
             23-05-01                      Gateway / 2 computers
             05-07-01                      Epson EMP projector
             11-07-01                      Demo model Genesis Il
             28-09-01                      Alphaserver 9.1 GB
             17-10-01                      Dell / computer dim 100
             18-12-01                      Autocad 2002
             23-01-02                      Latitude Pentium L400

             Date Acquired                 Description
             -------------                 -----------

             Office Equipment

             15-07-87                      Kantoren
             01-07-88                      Fax/Kopieer/div.
             01-01-89                      Meubelen
             01-02-89                      Meubelen
             01-02-89                      Meubelen
             01-03-89                      Meubelen
             01-04-89                      Inventaris
             01-04-89                      Meubelen
             01-07-89                      Meubelen
             01-09-89                      Recorder+Bijbehoren

                                                                           E-106
<PAGE>

          Date Acquired                   Description
          -------------                   -----------

          Office Equipment (Continued)

          06-03-90                        Vox 3200 (PTT)
          23-08-90                        Recorder DR4500
          31-12-90                        Beveiligingsinstall.
          22-02-91                        Lanier Telefax
          11-03-91                        Handpallettruck
          15-04-91                        2Werkbanken
          24-06-91                        Bureaus+stoelen
          08-01-92                        Overhead Projector
          29-01-92                        Tijdklok+kaartenbak
          06-04-92                        Kast + Oblique
          16-04-92                        Tafels
          26-06-92                        Stoelen+Kasten
          29-06-92                        Pocket memo
          16-07-92                        Projektor
          17-07-92                        Videorecorder
          28-07-92                        Koffiemachine
          28-07-92                        Tweedeurskast
          31-07-92                        Koelkast
          21-08-92                        Tweedeurskast
          23-11-92                        20Werkplekken
          11-01-93                        Oki Telefax
          13-01-93                        Diaprojektor
          25-01-93                        Private binder
          29-01-93                        Kast+Legbord
          29-01-93                        Stoelen+Tafels
          09-02-93                        Kantoorkast
          15-03-93                        Grijze kast
          25-03-93                        Televisie
          14-01-94                        Fax-modem
          18-03-94                        Kast+Legborden
          15-04-94                        2 Kantoorkasten
          11-05-94                        Ladenkast+slot
          03-06-94                        Werkplaatskasten
          12-08-94                        Papiervernietiger
          29-08-94                        Archiefstellingen
          28-09-94                        Stellingen
          12-10-94                        Werkplaatskasten
          18-11-94                        Kast Techn.Dienst
          11-01-95                        Kast+Hang/Legborden
          17-02-95                        Kasten + inhoud
          30-03-95                        Overtieadprojector
          01-05-95                        Vergaderruimte
          27-06-95                        Modem

                                                                           E-107
<PAGE>

          Date Acquired                   Description
          -------------                   -----------

          Office Equipment (Continued)

          27-07-95                        Koelkast
          20-02-96                        Overtoom/Kasten
          14-03-96                        Wilhelm/Kasten
          20-03-96                        Werkplaats Hal boven
          13-05-96                        Faxapp.+Toner
          08-11-96                        Okifax-apparaat
          01-10-88                        Meubelen
          20-03-90                        Paktafel
          10-01-94                        Verduist. gordijn
          17-11-94                        Stelling + Kast P.H.
          29-03-95                        Kast+Legborden
          25-04-95                        Vergaderruimtemeub.
          17-08-95                        Stoelen Lab.
          18-09-95                        Werkdraaistoelen
          30-09-95                        Diaprojector
          08-01-96                        Powerpoint (HB)
          22-01-96                        Transword woordboek
          13-02-96                        Nilfisk Stofzuiger
          20-02-96                        Overtoom/Kasten
          20-02-96                        Pathworks 5.1
          05-03-96                        Bureaustoel (LB)
          14-03-96                        Wilhelm/Kasten
          20-03-96                        Werkplaats Hal boven
          19-06-96                        Ladenkastjes
          27-08-96                        Vrieskast
          27-03-97                        Serverkast
          17-04-97                        Papiervernietigers
          24-04-97                        Basisstellingen
          08-07-97                        Dweilautomaat
          20-08-97                        Rekenmachines
          20-11-97                        Kast+Legborden
          29-01-98                        Burodraaistoelen
          30-01-98                        Tweedeurskast
          16-02-98                        Stofzuiger
          16-02-98                        2 Bureau's
          11-06-98                        Koelkast+Kasten
          28-05-99                        Brandblussers
          05-10-99                        Stansmes
          30-11-99                        Kantoor G.Kok
          31-12-99                        Multifunct.Koffer
          26-01-00                        Schoonmaakequipment
          29-02-00                        Mixers R&D
          23-03-00                        Draaistoel
          30-06-00                        Vaatwasser

                                                                           E-108
<PAGE>

          Date Acquired                   Description
          -------------                   -----------

          Office Equipment (Continued)

          31-08-00                        Bureau Werkruimte
          12-04-01                        Voetbaltafel
          20-07-01                        Archiefkast de Raat
          31-12-01                        overname vanuit APS
          03-01-02                        Koelkast kantineruimte
          18-01-02                        Inventaris sales

          Date Acquired                   Description
          -------------                   -----------

          Production/Lab Equipment

          01-03-88                        Drilmolen
          01-03-89                        Furnace
          01-06-89                        Weegschaal
          01-06-89                        Furnace
          01-04-89                        Powder Mill
          01-11-89                        Electric Furnace
          04-01-90                        Primixer
          08-01-90                        Wheel With Nut
          08-01-90                        Rotary Mobil Minor
          23-01-90                        Primixer
          05-03-90                        Membraampomp
          15-03-90                        Electr.Hydraul.Pers
          16-03-90                        Persmal
          01-05-90                        Alsint Kroezen
          25-07-90                        Naber Electr.Furnace
          04-10-90                        Membraampomp
          17-10-90                        Membraampomp
          16-11-90                        Slangenpomp
          23-11-90                        Filters Irac-24
          21-01-91                        Alsint Kroezen
          31-01-91                        Dubbel Thermokoppel
          01-02-91                        Plunjer voor Persmal
          08-02-91                        Primixer
          12-02-91                        Membraampomp
          19-02-91                        Aluminium Kroezen
          01-03-91                        Compressor+Dryer
          31-03-91                        Spray Dryer
          12-04-91                        Desktop X-Ray
          10-06-91                        Thermokoppels
          09-10-91                        Slangpompaandrijving
          25-10-91                        2 Primixers
          05-11-91                        2 Alsint Schalen
          07-12-91                        Mengapparaat

                                                                           E-109
<PAGE>

           Date Acquired                   Description
           -------------                   -----------

           Production/Lab Equipment
                         (Continued)

           07-01-92                        X-Ray Tube
           16-01-92                        Bovenplunjer
           04-05-92                        Heating Elements
           17-06-92                        Dubbelmembraanpomp
           23-06-92                        Granulaatdroger
           01-07-92                        Thermowell,-Koppel
           13-07-92                        Pellmix PL 1/8
           11-09-92                        Atomizing Nozzle
           21-09-92                        Primixer
           02-10-92                        Persmal
           09-11-92                        Kip recorder
           26-11-92                        Atomizer Wheel
           23-02-93                        Afzuigkappen
           21-03-94                        Objectief
           21-03-94                        Meetprojector
           06-06-94                        Datalogger
           20-12-94                        Uitbr.Sproeidroger
           09-10-97                        Technex/trekdrukbank
           31-10-97                        Visser/Granulaatmete
           24-02-98                        Alsint kroezen
           05-10-98                        Element Sinteroven
           06-11-98                        Trekdrukbank
           17-11-98                        Poederfilters
           18-08-99                        Revisie Sproeidroger
           27-08-99                        Filterkaarsen
           27-10-99                        Sinteroven revisie
           10-11-99                        Trekdrukbank
           02-12-99                        Alsint kroezen
           19-01-00                        Powder Cartridge
           31-01-00                        Powder Feed Assembly
           02-03-00                        Zeefmachine
           22-03-00                        Microwave processor
           21-09-00                        Filters
           01-01-87                        Roughnessmeter
           01-02-89                        Blaster
           20-02-91                        Blaster
           08-07-92                        Meetsonde
           15-12-94                        Blaster
           21-04-98                        Blaster
           01-07-86                        Plasma Unit
           01-10-87                        Turntable
           01-08-89                        Transformator

                                                                           E-110
<PAGE>

           Date Acquired                   Description
           -------------                   -----------

           Production/Lab Equipment
                         (Continued)

           23-01-90                        Kneefixtures
           09-03-90                        Tibial Kneefixtures
           14-02-90                        Powder Feed Unit
           24-08-90                        Stikstofinstallatie
           25-09-90                        Minitest 2000+Probe
           22-01-91                        Cup Fixtures
           31-03-91                        Plasma Gun
           16-09-91                        Hopper Assembly
           11-10-91                        Afzuigkast vd Robot
           11-11-91                        1 RVS Fixture
           31-12-91                        Fixtures
           19-12-91                        13 Fixtures
           09-01-92                        Permascope+Probe
           01-02-92                        Robotarm
           07-02-92                        8 Fixtures
           01-01-93                        Procesbank+Lab.tafel
           01-01-93                        Turntabel
           23-02-93                        Magnet. schakelaar
           26-04-94                        Koudwatermachine
           07-06-94                        Lasapparaat
           12-10-94                        Hipfixtures
           12-10-94                        Draaibank
           31-10-94                        Div. Fixtures
           31-12-94                        2 Amplifiers
           11-01-95                        Div. Fixtures
           24-04-95                        Plasma Spray Gun
           09-05-95                        Plasma Spray Gun
           17-08-95                        Power supply unit
           28-12-95                        Waterpomp
           08-04-97                        Revisie Gun
           29-05-97                        Houder Plasma Gun
           21-07-97                        Gun water ch.head
           31-08-97                        New Robot
           07-01-98                        Fixtures
           07-07-98                        AC-Regler IRT 1410
           07-08-98                        Water pomp
           26-08-98                        Air-pomp
           31-10-98                        Waterpomp
           21-01-99                        Fixtures
           29-04-99                        RVS Frames
           01-08-99                        Revisie Robot
           02-08-99                        Div.Fixtures
           13-12-99                        Div.Assembly's

                                                                           E-111
<PAGE>

           Date Acquired                   Description
           -------------                   -----------

           Production/Lab Equipment
                         (Continued)

           14-03-00                        Div.Nozzles
           20-03-00                        Div.Fixtures
           10-04-00                        Fixture
           13-04-00                        Coatingassen
           28-04-00                        Draaicilinder
           13-06-00                        Fixtures
           10-07-00                        Div.Nozzles
           25-08-00                        Gun Water Chan.Head
           01-11-89                        Ultrasonic Cleaner
           15-05-90                        Reinigingsapparaat
           24-06-91                        2 Sets Sealmallen
           31-05-91                        Spraytank + wagen
           16-04-91                        Sealmachine
           22-10-91                        Sealapparaat
           01-03-91                        Schrijvende meter
           07-02-91                        3Ultrareinigers
           12-04-91                        Clean Room div.
           13-02-92                        Sealmaster Magneta
           24-04-92                        Ultrasone Rein.Bad
           15-12-93                        Niro nylon filter
           10-02-93                        Vacuum Oven
           03-02-94                        Elfa/Reserve pomp
           19-07-99                        Ultrasonic Cleaner
           24-11-99                        RVS Frames
           01-07-88                        Compressor
           01-09-89                        Design Cube
           07-02-91                        Transformator T.380
           19-09-91                        Water Cool Assembly
           28-04-92                        Meetgereedschap
           22-06-92                        Micretain Filter
           24-06-92                        Beschermkappen
           10-11-92                        Droger/Compressor
           31-12-92                        Control Unit
           01-06-93                        Co2 blussers
           28-03-95                        Ovenonderdelen
           22-08-95                        Stansvormen Tape
           03-01-97                        Linn Element
           30-06-97                        Frequentieregelaar
           01-09-97                        Vacuum-cleaner
           25-02-98                        Hunter/Tumbler
           10-09-98                        Robot disc drive
           31-01-99                        Ampere meter
           09-03-99                        Oven XL124

                                                                           E-112
<PAGE>

           Date Acquired                   Description
           -------------                   -----------

           Production/Lab Equipment
                         (Continued)

           15-10-99                        Boor-Freesmachine
           10-11-99                        Display 300-plus
           24-11-99                        Statische menger
           23-03-00                        Opbergbakken
           04-05-00                        Boohr Albrecht
           08-06-00                        Verwarmingselementen
           31-08-00                        Ineste Ovenparts
           15-02-91                        Microscoop
           16-05-91                        Sealbalk
           22-08-95                        Testostor
           01-07-88                        Installation Lab.
           01-01-90                        Transformator
           09-03-90                        Nat Doorslijpmachine
           12-06-90                        Weegschaal
           10-09-90                        Standard V-Kast
           06-02-91                        Electric Furnace
           19-03-91                        Alum. Oxyde Kroezen
           31-03-92                        Polijstmachine
           07-07-92                        Luftstrahlsieb
           02-02-93                        Laboratoriummeubels
           18-07-94                        Airb. Part. Counter
           30-06-94                        Metco waterpomp
           22-08-94                        ARO Test-a-pack
           03-03-95                        Plasma waterzuiver.
           04-05-95                        Gloeischaal
           17-05-95                        Zeefmachine
           01-09-95                        Temperatuur Calibr.
           23-09-96                        Microscoop
           31-01-97                        Bovenweger
           30-07-97                        Linn Elements
           31-07-97                        Interface Balance
           26-08-97                        Linn Elements
           29-10-97                        2xPLGEL Kolommen
           11-11-97                        Vleugelrandsonde M/S
           21-11-97                        Jumbo regelaar
           12-12-97                        Alum. Oxide Plaat
           31-12-97                        Meetapp.Granulaat
           28-01-98                        Druksonde
           31-03-98                        Kogelset Convatec
           02-12-99                        Digital Viscometer
           31-01-00                        X-Raylube
           01-03-00                        Digitale Camera
           26-06-00                        Linn Element

                                                                           E-113
<PAGE>

           Date Acquired                   Description
           -------------                   -----------

           Production/Lab Equipment
                         (Continued)

           17-10-00                        afvalcontainers
           17-10-00                        algemeen december2000
           15-09-00                        Donaldson Torit
           30-10-00                        Electrische oven
           05-12-00                        Ruwheidsmeter
           29-12-00                        Diaphragm pomp
           23-01-01                        Statische menger
           26-01-01                        Glascentrale
           04-02-01                        Donaldson Torit
           12-03-01                        Sulzer / vibrator assy
           29-03-01                        Rep. RD-installatie
           30-03-01                        CTA water pomp
           20-04-01                        Alkemade / diverse platen
           27-04-01                        Vacuum pomp
           23-05-01                        Elect. aangedreven trilgoot
           11-06-01                        Zeefschudmachine
           01-06-01                        Blokkenpers
           07-08-01                        Microscoop adapter
           17-08-01                        Koelerblok
           19-09-01                        Vacuum standaard
           12-10-01                        Technex krachtopnemer
           03-04-01                        Vibrator Assy
           29-03-01                        Sealmallen
           11-05-01                        Koelerblok
           20-12-01                        Breekmolen
           31-12-01                        Inventans CAM/APS
           17-04-02                        Snijstaal Sinteroven
           08/02/02                        Thickness meter Titanium

The above includes all Equipment of the Seller as of March 31, 2002 as reflected
in the Preliminary Balance Sheet with a net book value of ***.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-114
<PAGE>

SCHEDULE 2 - STOCK

            Stock as of March 31, 2002:

               Raw Materials                     ***
               Finished Goods                    ***
               Total
----------
******Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-115
<PAGE>

SCHEDULE 3 - INTELLECTUAL PROPERTY RIGHTS

1.    The product names, including all their registrations and pending
      applications, "CAMCERAM" and "TAM".

2.    The company name "CAM Implants BV.", including its registration
      certificate at the "Benelux Merkenbureau" (CAM document nr. 23)

3.    The CE registration for "CAMCERAM", consisting of certificates G1 01 06
      43847 001 and G7 00 12 20268 005

4.    THE ISO 9001-1994/EN 46001:1093 certificate Q1Z 00 01 20268 004

5.    The FDA Master File 298

6.    The registration of the existing internet domain www.camimplants.nl and
      all rights and obligations adhering to it.

                                                                           E-116
<PAGE>

SCHEDULE 4 - RECEIVABLES

Customer Number                                Customer Name
---------------                                -------------

***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***
***                           ***

The above includes all customers of the Seller as of March 31, 2002 whom owe the
Seller for services performed or product delivered as reflected in the
Preliminary Balance Sheet in the aggregrate amount, net of allowances, of ***.

All amounts due from any other Group Company as detailed on the Preliminary
Balance Sheet are expressly excluded from this Agreement and will not be sold or
transferred by the Seller to the Purchaser.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-117
<PAGE>

                               45: CAM Implants BV
                          Aged Debt Report by Due Date
                          Division: 45 CAM Implants BV.
                      in Base Currency: EUR: Euro Currency

<TABLE>
<CAPTION>
                      Total         1-Jun-2002 to         1-May to       1-Apr to       1-Mar to           Before           In
                   Outstanding       9-JUL-2002         31-May 2002    30-Apr 2002      31-Mar 20        28-Feb 2002      Dispute
<S>                <c>              <C>                         <C>            <C>            <C>               <C>              <C>
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***

TOTAL for
Currency: EUR      ***                                          ***            ***            ***               ***              ***
</TABLE>

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-118
<PAGE>

SCHEDULE 5 - PERMITS

1.    Oprichtingsvergunning nr.18616/92 d.d. 26 maart 1993

2.    Uitbreidingsvergunning nr. 18841/94 d.d.2 dec 1994

3.    Artikel 8.19 melding nr.22172/96 d.d.12 nov 1996

4.    Uitbreidingsvergunning nr.20093/98 d.d.27 nov 1998

5.    Uitbreidingsvergunning nr.23008/98 d.d.29 jan 1999

6.    Artikel 8.19 melding nr.21506/99 d.d.27 nov 1999

7.    Definitieve beschikking nr.266/03 d.d. 12 april 2001

8.    I-linderwetvergunning + bijlagen (CAM document 100 and 101)

9.    Bouwvergunning (CAM document 295)

NOTE:

Items 1-9 all concern the construction of the office building at Zernikedreef 6
in Leiden. In the course of time, cleanroom extensions to the building have been
made. Item 8, "Hinderwetvergunning", recognizes CAM's operations to comply with
environmental regulations and as such allows CAM to operate its facility.

                                                                           E-119
<PAGE>

SCHEDULE 6 - THE RIGHTS AND OBLIGATIONS ARISING FROM THE CONTRACTS

CAM Nr                        Description                                Party

None          ***                                        ***
406           ***                                        ***
498           ***                                        ***
27            ***                                        ***
515           ***                                        ***
31            ***                                        ***
34            ***                                        ***
33            ***                                        ***
500           ***                                        ***
467           ***                                        ***
72            ***                                        ***
69            ***                                        ***
70            ***                                        ***
71            ***                                        ***
512           ***                                        ***
519           ***                                        ***
447           ***                                        ***
80            ***                                        ***
79            ***                                        ***
80            ***                                        ***
90            ***                                        ***
513           ***                                        ***
506           ***                                        ***
96            ***                                        ***
360           ***                                        ***
470           ***                                        ***
408           ***                                        ***
518           ***                                        ***
453           ***                                        ***
501           ***                                        ***
451           ***                                        ***
483           ***                                        ***
127           ***                                        ***
128           ***                                        ***
499           ***                                        ***

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-120
<PAGE>

CAM Nr                        Description                                Party

412           ***                                        ***
156           ***                                        ***
516           ***                                        ***
352           ***                                        ***
497           ***                                        ***
339           ***                                        ***
184           ***                                        ***
464           ***                                        ***
211           ***                                        ***
212           ***                                        ***
213           ***                                        ***
223           ***                                        ***
453           ***                                        ***
224           ***                                        ***
246           ***                                        ***
247           ***                                        ***
478           ***                                        ***
445           ***                                        ***
257           ***                                        ***
459           ***                                        ***
493           ***                                        ***
462           ***                                        ***
511           ***                                        ***
268           ***                                        ***
487           ***                                        ***
288           ***                                        ***
472           ***                                        ***
290           ***                                        ***
291           ***                                        ***
526           ***                                        ***
446           ***                                        ***
None          ***                                        ***
None          ***                                        ***

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-121
<PAGE>

SCHEDULE 7 - LIABILITIES ACCOUNTED FOR IN THE PRELIMINARY BALANCE SHEET

                                                                    As Of
                                                               March 3l, 2002
                                                               --------------

Accounts payable                                                    ***
Payroll taxes                                                       ***
Social security charges                                             ***
Holiday allowance                                                   ***
Year-end bonus allowance                                            ***
Accrued Insurance                                                   ***
Accrued legal fees                                                  ***
Accrued severance                                                   ***
Accrued accounting fees                                             ***
Accrued consulting fees                                             ***
Accrued other liabilities                                           ***
                                                                    ***

All amounts due to any other Group Company as detailed on the Preliminary
Balance Sheet are expressly excluded from this Agreement and will not be sold or
transferred by the Seller to the Purchaser. In addition, all income tax
liabilities and related valuation reserves are expressly excluded from this
Agreement and will not be sold or transferred by the Seller to the Purchaser.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-122
<PAGE>

SCHEDULE 8 - TERMS AND CONDITIONS OF EMPLOYMENT BY THE SELLER OF ALL EMPLOYEES

All amounts are in euros

<TABLE>
<CAPTION>
--------------------------------------------------------------------------------------------------------

          NAME
---------------------------      DATE OF     MALE/                           ENGAGEMENT     GROSS SALARY
LAST                  FIRST       BIRTH     FEMALE         FUNCTION             DATE         PER MONTH
--------------------------------------------------------------------------------------------------------
<S>                     <C>        <C>        <C>     <C>                    <C>                 <C>
AZIER                   M.         ***        ***     PROD.MEDEWERKER        04/01/1997          ***
--------------------------------------------------------------------------------------------------------
BOKHORST                R.         ***        ***     OPERATIONS MGR.        06/16/1989          ***
--------------------------------------------------------------------------------------------------------
CHARDONNENS             J.L.       ***        ***     PROD.MEDEWERKER        10/15/2001          ***
--------------------------------------------------------------------------------------------------------
COX                     A.G.       ***        ***     STUDENT (TEMP.)        11/01/2001          ***
--------------------------------------------------------------------------------------------------------
DOUIDI                  M.B.B.     ***        ***     PROD.MEDEWERKER        12/10/1997          ***
--------------------------------------------------------------------------------------------------------
DOUZ                    L.         ***        ***     PROD.MEDEWERKER        09/22/1999          ***
--------------------------------------------------------------------------------------------------------
DRIESSEN                A.A.       ***        ***     MANAGER R & D          04/26/1995          ***
--------------------------------------------------------------------------------------------------------
GROEN                   R.         ***        ***     TEAMLEIDER PROD.       09/13/1995          ***
--------------------------------------------------------------------------------------------------------
HILGERS                 Y.D.       ***        ***     PROD.MEDEWERKER        04/05/2002          ***
--------------------------------------------------------------------------------------------------------
HOEVEN TEN              C.         ***        ***     MARKETING MGR.         05/01/2001          ***
--------------------------------------------------------------------------------------------------------
HOOG DE                 M.         ***        ***     ASS.CUSTOM SERVICE     06/16/1999          ***
--------------------------------------------------------------------------------------------------------
JOHNSON                 P.A.       ***        ***     ANALIST                03/19/2001          ***
--------------------------------------------------------------------------------------------------------
KOK                     G.A.       ***        ***     GENERAL MANAGER        04/01/1998          ***
--------------------------------------------------------------------------------------------------------
KOOPMANS                P.R.       ***        ***     ENGINEER               04/01/1990          ***
--------------------------------------------------------------------------------------------------------
KRUIDHOF                R.S.       ***        ***     RECEPTION              06/01/2000          ***
--------------------------------------------------------------------------------------------------------
KUS                     F.         ***        ***     PROD.MEDEWERKER        04/17/2000          ***
--------------------------------------------------------------------------------------------------------
LALE                    S.         ***        ***     PROD. ANALIST          06/01/1992          ***
--------------------------------------------------------------------------------------------------------
LEER VAN-SCHLAGHECK     K.S.       ***        ***     CUSTOMER SERVICE       06/01/1993          ***
--------------------------------------------------------------------------------------------------------
MEI VAN DER             F.B.       ***        ***     PROD.MEDEWERKER        09/10/2001          ***
--------------------------------------------------------------------------------------------------------
NIEUWENHUIZEN           L.M.F.     ***        ***     PROD.MEDEWERKER        11/01/2001          ***
--------------------------------------------------------------------------------------------------------
OUSHOORN                P.J.       ***        ***     SYSTEM BEHEERDER       11/01/1988          ***
--------------------------------------------------------------------------------------------------------
ROBBERS                 E.G.P.     ***        ***     TEAMLEIDER PROD.       04/01/1995          ***
--------------------------------------------------------------------------------------------------------
SCHIE VAN               J.         ***        ***     R&D MEDEWERKER         05/01/2002          ***
--------------------------------------------------------------------------------------------------------
TAMIMI AL               A.         ***        ***     PROD.MEDEWERKER        10/01/2000          ***
--------------------------------------------------------------------------------------------------------
VIELE                   B.         ***        ***     PROD.MEDEWERKER        05/01/2000          ***
--------------------------------------------------------------------------------------------------------
VLIET                   M.         ***        ***     PROD.MEDEWERKER        04/02/2002          ***
--------------------------------------------------------------------------------------------------------
WIERS                   G.A.       ***        ***     Q&A MANAGER            01/01/2001          ***
--------------------------------------------------------------------------------------------------------

<CAPTION>
-----------------------------------------------------------------------------------------------------------
                                                                                          NET
          NAME                     GROSS                                                EXPENSE
---------------------------        SALARY        CODE      ZKV     GROSS       CAR         S        SUNDRY
LAST                  FIRST       PER YEAR       +++       PER    EXPENSES  (LESS NET)  TRAVEL       GROSS
-----------------------------------------------------------------------------------------------------------
<S>                     <C>         <C>         <C>         <C>       <C>        <C>      <C>          <C>
AZIER                   M.          ***               A
-----------------------------------------------------------------------------------------------------------
BOKHORST                R.          ***         A-C-P-S     ***       ***        ***                   ***
-----------------------------------------------------------------------------------------------------------
CHARDONNENS             J.L.        ***               A                                   ***
-----------------------------------------------------------------------------------------------------------
COX                     A.G.        ***               A
-----------------------------------------------------------------------------------------------------------
DOUIDI                  M.B.B.      ***               A
-----------------------------------------------------------------------------------------------------------
DOUZ                    L.          ***               A
-----------------------------------------------------------------------------------------------------------
DRIESSEN                A.A.        ***               A     ***       ***        ***
-----------------------------------------------------------------------------------------------------------
GROEN                   R.          ***               A                                   ***
-----------------------------------------------------------------------------------------------------------
HILGERS                 Y.D.        ***               A
-----------------------------------------------------------------------------------------------------------
HOEVEN TEN              C.          ***         A-C-P-S     ***       ***        ***                   ***
-----------------------------------------------------------------------------------------------------------
HOOG DE                 M.          ***               A
-----------------------------------------------------------------------------------------------------------
JOHNSON                 P.A.        ***           A-P-S                                   ***
-----------------------------------------------------------------------------------------------------------
KOK                     G.A.        ***           C-P-S     ***                  ***
-----------------------------------------------------------------------------------------------------------
KOOPMANS                P.R.        ***           A-P-S     ***                           ***          ***
-----------------------------------------------------------------------------------------------------------
KRUIDHOF                R.S.        ***             A-S
-----------------------------------------------------------------------------------------------------------
KUS                     F.          ***             A-S
-----------------------------------------------------------------------------------------------------------
LALE                    S.          ***           A-P-S
-----------------------------------------------------------------------------------------------------------
LEER VAN-SCHLAGHECK     K.S.        ***               A
-----------------------------------------------------------------------------------------------------------
MEI VAN DER             F.B.        ***               A
-----------------------------------------------------------------------------------------------------------
NIEUWENHUIZEN           L.M.F.      ***               A                                   ***
-----------------------------------------------------------------------------------------------------------
OUSHOORN                P.J.        ***           A-P-S     ***                                        ***
-----------------------------------------------------------------------------------------------------------
ROBBERS                 E.G.P.      ***               A
-----------------------------------------------------------------------------------------------------------
SCHIE VAN               J.          ***               A
-----------------------------------------------------------------------------------------------------------
TAMIMI AL               A.          ***               A                                   ***
-----------------------------------------------------------------------------------------------------------
VIELE                   B.          ***               A
-----------------------------------------------------------------------------------------------------------
VLIET                   M.          ***               A
-----------------------------------------------------------------------------------------------------------
WIERS                   G.A.        ***           A-P-S     ***       ***                 ***
-----------------------------------------------------------------------------------------------------------
</TABLE>

+++   GENERAL AND CODES:

ALL EMPLOYEES PAY PENSIONPREMIUM (50%) AND "WAD-GAT" INSURANCE (50%)

A = INCLUDING HOLIDAY ALLOWANCE (8%) AND 13E MONTH

C = COMPANY CAR

P = PREMIESPAAR

S = SPAARLOON

PARTIMERS:

COX                             30% FTE
HOOG DE                         70% FTE
KRUDHOF                         75% FTE
LEER VAN-SCHLAGHECK             60% FTE

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-123
<PAGE>

                                                                   Exhibit 10.59

SCHEDULE 9 - DEED OF ASSIGNMENT

This Deed is made and entered into by and between the following Parties:

1.    CAM IMPLANTS B.V., a company duly organized and existing under the laws of
      the Netherlands, having its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, duly represented by Michael John Jeffries,
      hereinafter referred to as the "Assignor";

and

2.    CAM ACQUISITION B.V., a company duly organized and existing under the laws
      of the Netherlands, having its registered office at Zernikedreef 6, 2333
      CL, Leiden, the Netherlands, duly represented by Gerard Anton Kok on
      behalf of G.A. Kok Beheer B.V., hereinafter referred to as the "Assignee";

WHEREAS:

-     Assignor is the proprietor of copyrights, database rights, designs,
      internet domain names, licensee rights, patents, trademarks, tradenames
      and/or trade secrets, along with any and all income, royalties, damages
      and payments at any time due or payable to Assignor with respect thereto,
      including without limitation damages and payments for past or future
      infringements or misappropriations thereof, in any state or country,
      (hereinafter the "IP Rights"). The IP Rights include, but are not limited
      to, the rights and/or items as set forth in Annex I;

-     Assignor is the proprietor of any and all rights in the registrations as
      set forth in Annex II (hereinafter the "Registration Rights" and together
      with the IP Rights jointly referred to as the "Rights")

-     The Assignee has entered into an Asset Purchase Agreement with Assignor in
      connection with which the Assignee is entitled to obtain any and all
      rights, title and interest in the Rights;

NOW THEREFORE, in consideration of the mutual covenants, promises and
undertakings set forth herein, the Parties hereby agree as follows:

Transfer and assignment

1.    The Assignor hereby assigns and transfers to the Assignee any and all
      rights, title and interest in the Rights, free and unencumbered. Assignee
      hereby accepts such rights, title and interest in the Rights.

2.    The Assignee acquires the Rights from the Assignor for a total
      consideration of EUR 1,-.

3     The Assignor shall make, do or execute all documents, acts, matters or
      writings which the Assignee deems necessary or desirable to give full
      effect to the provisions of this Deed.

                                                                           E-124
<PAGE>

                                                                        10/07/02

      For that purpose this Deed or extracts thereof may be registered with the
      relevant registration office(s).

      For the event that for any part of any of the IP Rights this Deed would
      not fully constitute full transfer and assignment of any and all rights,
      title and interest and additional requirements would apply to that effect,
      the Assignor hereby grants to Assignee, and Assignee hereby accepts, the
      unlimited, worldwide, perpetual, royalty-free exclusive license to use and
      exploit such IP Rights as of the date of undersigning this Deed until any
      and all such additional requirements for full transfer and assignment have
      been executed and effectuated.

      Miscellaneous

4.    The Assignor warrants that it is the owner of the Rights and that third
      parties do not have any direct or indirect rights, titles or interests in
      the Rights or in relation thereto.

5.    The Assignor states to its best knowledge that it is not aware of any
      wrongful use by any third party of the Rights and the Assignor furthermore
      states that to its best knowledge the Rights are not infringing any rights
      of third parties.

6.    The Assignor shall render to the Assignee, at the Assignee's first
      request, any reasonable assistance which the Assignee deems necessary or
      desirable to defend or prosecute any of the Rights, provided that any and
      all reasonable costs and expenses of the Assignor shall be reimbursed by
      the Assignee.

7.    This Deed shall in all respects be exclusively governed by and deemed to
      have been construed in accordance with the laws of the Netherlands.

8.    Any dispute or claim arising out of or in connection with this Deed shall
      be referred to and exclusively and finally settled by the competent court
      in The Hague, the Netherlands.

This Deed has been signed in two original copies on 10 July 2002.

--------------------------------        ----------------------------------------
CAM IMPLANTS B.V.                       CAM Acquisition B.V.

by: Michael John Jeffries               on behalf of G.A. Kok Beheer B.V.

title: Director                         by: Gerard Anton Kok

                                        title: Director of G.A. Kok Beheer B.V.

                                                                           E-125
<PAGE>

                                                                        10/07/02

ANNEX I

1.    The product names, including all their registrations and pending
      applications, "CAMCERAM" and "TAM".

2.    The company name "CAM Implants B.V.", including its registration
      certificate at the "Benelux Merkenbureau" (CAM document nr. 23).

ANNEX II

1.    The CE registration for "CAMCERAM", consisting of certificates G1 01 06
      43847 001 and G7 00 12 20268 005.

2     THE ISO 9001-1994/ EN 46001:1093 certificate Q1Z 00 01 20268 004.

3.    The FDA Master File 298.

4.    The registration of the existing internet domain www.camimplants.nl and
      all rights and obligations adhering to it.

                                                                           E-126
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 10 - DEED OF PLEDGE OF EQUIPMENT

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

NOW THEREFORE the parties hereto have agreed as follows:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement.

      "Goods" means all of the Pledgor's present and future machinery, equipment
      and inventory, including without limitations, fittings, furnishings,
      office equipment, automobiles and other rolling assets, as well as
      goods/movables forming part thereof or appurtenant thereto, all in the
      broadest sense of the word.

                                                                           E-127
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Default" has the meaning as defined in clause 7 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, all its Goods regardless of their condition and
      location, which pledge the Pledgee hereby accepts.

2.2   The Pledgee is entitled, at its discretion, to have this deed registered
      or to have the right of pledge recorded in a notarial deed. The Pledgor
      hereby grants irrevocable power of attorney to the Pledgee to have the
      pledge recorded in a notarial deed at any time, whether before or after
      registration of this deed, if the Pledgee so desires. For that purpose the
      Pledgee is authorised to execute such notarial deed on behalf of the
      Pledgor.

3.    Representations and Warranties

3.1   The Pledgor represents and warrants to the Pledgee that:

      (i)   it has power ("beschikkingsbevoegdheid") to pledge the Goods;

      (ii)  to the best of its knowledge, the Goods are not subject to any
            attachments ("beslag"), nor are any limited rights ("beperkte
            rechten") levied thereon or vested therein for the benefit of third
            parties, other than in accordance with clause 5.2 of the Agreement,
            nor are they subject to any right of retention ("retentierecht");

      (iii) it has not previously and/or in advance transferred or created or
            promised to transfer or create, limited property rights on or
            against any of the Goods, or any part thereof, to or in favour of
            third parties, other than in accordance with clause 5.2 of the
            Agreement;

      (iv)  the Goods are capable of being pledged in the manner set out herein.

4.    Ranking

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Covenants

                                                                           E-128
<PAGE>

                                                           Stibbe Draft 10/07/02

5.1   The Pledgor undertakes to ensure that, upon its acquisition of the Goods,
      no limited rights are retained therein by the transferor. To the extent
      that its acquisition of any Goods is subject to a retention of title, the
      Pledgor further undertakes to perform its obligations to the transferor in
      a timely and proper manner.

5.2   The Pledgor shall use the Goods in its Business only and in a manner
      consistent with their ordinary nature and purpose. The Pledgor will
      maintain the Goods in good repair and condition and do all that is
      necessary and/or deemed desirable by the Pledgee for this purpose. It
      shall neither take nor fail to take any action reasonably acquired in
      relation to the Goods, which could prejudice the interests of the Pledgee.
      If the Pledgor is in default of these obligations, the Pledgee shall be
      entitled to do whatever is reasonably necessary at the Pledgor's expense,
      without prejudice to its other rights.

5.3   The Pledgor undertakes to provide to the Pledgee, forthwith upon the
      latter's request to that effect at any time, a further specification of
      the Goods and/or the locations where they are situated. The failure to
      provide any such specification or the omission therefrom of any one or
      more of the Goods, shall not in any way detract from all Goods being
      pledged. The Pledgee and/or its appointees for this purpose shall be
      granted free access to the locations where the Goods are situated, in
      order to verify their presence and condition, during normal business
      hours. The refusal by a third party to grant such access shall be deemed a
      refusal by the Pledgor.

5.4   If at any time the Goods or any part thereof is held on its behalf by a
      third party, the Pledgor shall give immediate notice to such third party
      of the pledge of such Goods to the Pledgee. The Pledgor hereby grants
      irrevocable power of attorney to the Pledgee to do so itself, on its own
      and the Pledgor's behalf, if it so desires. To the extent any documents of
      storage or transportation are issued in respect of the Goods, such
      documents shall be immediately delivered and pledged to the Pledgee (in
      the case of endorsable commercial paper by way of endorsement).

5.5   The Pledgor shall, at its expense, have and hold the Goods insured on the
      usual conditions. It shall produce the policies of the relevant insurances
      to the Pledgee for review at the latter's first request. If the Pledgor is
      in default of this obligation, the Pledgee shall be entitled to arrange
      for insurance to its satisfaction at the Pledgor's expense. Upon the
      creation of a pledge as referred to in Article 3:229 of the Netherlands
      Civil Code ("NCC"), the Pledgee shall be entitled to give notice thereof
      to those held to indemnify.

5.6   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Goods, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

                                                                           E-129
<PAGE>

                                                           Stibbe Draft 10/07/02

5.7   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the Goods,
      failing which the Pledgee shall be entitled to give such notice.

6.    Alienation, Use

      Subject to clause 5.2 of the Agreement, the Pledgor may not alienate,
      encumber, lease or otherwise grant the use of the Goods to third parties
      without the prior written consent of the Pledgee, unless the price to be
      paid for such Goods by third parties does not exceed an aggregate amount
      of USD 15,000 quarterly. Upon the alienation of any Goods, the Pledgor
      shall replace such Goods in order to maintain the interests of the
      Pledgee.

7.    Possessory Pledge

      The Pledgee may require at any time when the Pledgor has not fulfilled or
      paid its Secured Obligations ("Event of Default"), all or a part of the
      Goods to be brought into its possession or that of a third party jointly
      appointed by it for this purpose.

8.    Enforcement

8.1   In case of an Event of Default, the Pledgee shall be entitled to sell the
      Goods and to recover the outstanding amount from the proceeds of sale.

8.2   In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties who have limited rights in or who have levied an
      attachment on any of the Goods, nor shall the Pledgee be obliged to give
      notice that a sale has occurred. The Pledgor hereby waives its right to
      apply to the President of the District Court for an order that the Goods
      be sold in a manner different from that provided for in Article 3:250 NCC
      and, if applicable, its rights under Article 3:234 NCC.

9.    Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Goods, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

10.   Release of Pledge

      The Pledgee shall only be held to release its pledge if, it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

11.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

                                                                           E-130
<PAGE>

                                                           Stibbe Draft 10/07/02

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Goods or the exercise of any rights vested in the Pledgee.

12.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

13.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

14.   Powerof Attorney

14.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Goods or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Goods or under or in connection with this
            deed.

14.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

15.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

16.   Amendments and Waivers

                                                                           E-131
<PAGE>

                                                           Stibbe Draft 10/07/02

16.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

16.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

17.   Governing Law and Jurisdiction

17.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

17.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

                                        --------------------------------------
                                         CAM Acquisition B.V.
--------------------------------
CAM IMPLANTS B.V.                       on behalf of G.A. Kok Beheer B.V.

by: Michael John Jeffries               by: Gerard Anton Kok

title: Director                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-132
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 10 - DEED OF PLEDGE OF STOCK

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property forthe benefit
      of the Pledgee;

NOW THEREFORE the parties hereto have agreed as follows:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Stock" means all of the Pledgor's present and future stock, including raw
      materials, ancillary materials and semi-finished products, as woll as
      packaging material, all in the broadest sense of the word.

                                                                           E-133
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Default" has the meaning as defined in clause 7 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, all its Stock regardless of their condition and
      location, which pledge the Pledgee hereby accepts.

2.2   The Pledgee is entitled, at its discretion, to have this deed registered
      or to have the right of pledge recorded in a notarial deed. The Pledgor
      hereby grants irrevocable power of attorney to the Pledgee to have the
      pledge recorded in a notarial deed at any time, whether before or after
      registration of this deed, if the Pledgee so desires. For that purpose the
      Pledgee is authorised to execute such notarial deed on behalf of the
      Pledgor.

3.    Representations and Warranties

3.1   The Pledgor represents and warrants to the Pledgee that:

      (i)   it has power ("beschikkingsbevoegdheid") to pledge the Stock;

      (ii)  the Stock is not subject to any attachments ("beslag"), nor are any
            limited rights ("beperkte rechten") levied thereon or vested therein
            for the benefit of third parties, other than in accordance with
            clause 5.2 of the Agreement, or any right of retention
            ("retentierecht");

      (iii) it has not previously and/or in advance transferred or created or
            promised to transfer or create, limited property rights on or
            against any of the Stock, or any part thereof, to or in favour of
            third parties, other than in accordance with clause 5.2 of the
            Agreement;

      (iv)  the Stock is capable of being pledged in the manner set out herein.

4.    Ranking

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Covenants

                                                                           E-134
<PAGE>

                                                           Stibbe Draft 10/07/02

5.1   The Pledgor undertakes to ensure that, upon its acquisition of the Stock,
      no limited rights are retained therein by the transferor. To the extent
      that its acquisition of any Stock is subject to a retention of title, the
      Pledgor further undertakes to perform its obligations to the transferor in
      a timely and proper manner.

5.2   The Pledgor shall use the Stock in its Business only and in a manner
      consistent with their ordinary nature and purpose. The Pledgor will
      maintain the Stock in good repair and condition and do all that is
      necessary and/or deemed desirable by the Pledgee for this purpose. It
      shall neither take nor fail to take any action reasonably required in
      relation to the Stock, which could prejudice the interests of the Pledgee.
      If the Pledgor is in default of these obligations, the Pledgee shall be
      entitled to do whatever is reasonably necessary at the Pledgor's expense,
      without prejudice to its other rights.

5.3   The Pledgor undertakes to provide to the Pledgee, forthwith upon the
      latter's request to that effect at any time, a further specification of
      the Stock and/or the locations where they are situated. The failure to
      provide any such specification or the omission therefrom of any one or
      more of the Stock, shall not in any way detract from all Stock being
      pledged. The Pledgee and/or its appointees for this purpose shall be
      granted free access to the locations where the Stock are situated, in
      order to verify their presence and condition, during normal business
      hours. The refusal by a third party to grant such access shall be deemed a
      refusal by the Pledgor.

5.4   If at any time the Stock or any part thereof are held on its behalf by a
      third party, the Pledgor shall give immediate notice to such third party
      of the pledge of such Stock to the Pledgee. The Pledgor hereby grants
      irrevocable power of attorney to the Pledgee to do so itself, on its own
      and the Pledgor's behalf, if it so desires. To the extent any documents of
      storage or transportation are issued in respect of the Stock, such
      documents shall be immediately delivered and pledged to the Pledgee (in
      the case of endorsable commercial paper by way of endorsement).

5.5   The Pledgor shall, at its expense, have and hold the Stock insured on the
      usual conditions. It shall produce the policies of the relevant insurances
      to the Pledgee for review at the latter's first request. If the Pledgor is
      in default of this obligation, the Pledgee shall be entitled to arrange
      for insurance to its satisfaction at the Pledgor's expense. Upon the
      creation of a pledge as referred to in Article 3:229 of the Netherlands
      Civil Code ("NCC"), the Pledgee shall be entitled to give notice thereof
      to those held to indemnify.

5.6   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Stock, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

                                                                           E-135
<PAGE>

                                                           Stibbe Draft 10/07/02

5.7   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the Stock,
      failing which the Pledgee shall be entitled to give such notice.

6.    Alienation, Use

      Subject to clause 5.2 of the Agreement and other than in the ordinary
      course of business, the Pledgor may not alienate, encumber, lease or
      otherwise grant the use of the Stock to third parties without the prior
      written consent of the Pledgee. Upon the alienation of any Stock, the
      Pledgor shall replace such Stock in order to maintain the interests of the
      Pledgee.

7.    Possessory Pledge

      The Pledgee may require at any time when the Pledgor has not fulfilled or
      paid its Secured Obligations ("Event of Default"), all or a part of the
      Stock to be brought into its possession or that of a third party appointed
      by it for this purpose.

8.    Enforcement

8.1   In case of an Event of Default, the Pledgee shall be entitled to sell the
      Stock and to recover the outstanding amount from the proceeds of sale.

8.2   In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties who have limited rights in or who have levied an
      attachment on any of the Stock, nor shall the Pledgee be obliged to give
      notice that a sale has occurred. The Pledgor hereby waives its right to
      apply to the President of the District Court for an order that the Stock
      be sold in a manner different from that provided for in Article 3:250 NCC
      and, if applicable, its rights under Article 3:234 NCC.

9.    Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Stock, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

10.   Release of Pledge

      The Pledgee shall only be held to release its pledge if it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

11.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

                                                                           E-136
<PAGE>

                                                           Stibbe Draft 10/07/02

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Stock or the exercise of any rights vested in the Pledgee.

12.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

13.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

14.   Power of Attorney

14.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Stock or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Stock or under or in connection with this
            deed.

14.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

15.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

16.   Amendments and Waivers

                                                                           E-137
<PAGE>

                                                           Stibbe Draft 10/07/02

16.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

16.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

17.   Governing Law and Jurisdiction

17.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

17.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

                                         ---------------------------------------
                                         CAM Acquisition B.V.
--------------------------------
CAM IMPLANTS B.V.                        on behalf of G.A. Kok Beheer B.V.

by: Michael John Jeffries                by: Gerard Anton Kok

title: Director                          title: Director of G.A. Kok Beheer B.V.

                                                                           E-138
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 10 - DEED OF PLEDGE OF RECEIVABLES

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

NOW THEREFORE the parties hereto agree as follows:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Receivables" means all receivables ("vorderingen op naam") of the Pledgor
      on third parties, whether for goods delivered, services performed or for
      any other reason whatsoever;

                                                                           E-139
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Default" has the meaning as defined in clause 8 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, which pledge the Pledgee hereby accepts, the
      Receivables, insofar as these are capable of being pledged on the date of
      signing this deed, and undertakes to pledge to the Pledgee the Receivables
      which become capable of being pledged after the date of signing this deed
      as soon as such Receivables shall be capable of being so pledged.

2.2   For the first time upon the signing of this deed, and thereafter as soon
      as any Receivables are capable of being pledged at three monthly
      intervals, the Pledgor shall deliver to the Pledgee pledge lists in the
      form of Annex A hereto, duly signed and completed, and identifying all
      Receivables which are then capable of being pledged. By accepting delivery
      of any pledge list, the Pledgee accepts the pledge to it of the
      Receivables identified thereon. The Pledgee may, at its discretion,
      register or have registered this deed together with the pledge lists, or
      have such deed and lists recorded in a notarial deed. In the latter event,
      the Pledgee is authorised to execute the notarial deed on behalf of the
      Pledgor.

2.3   The first pledge list shall be attached to this deed, and the Pledgor
      shall thereafter deliver pledge lists to the Pledgee at its first request
      at least once every three months (i.e. end of February, end of May, end of
      August and end of November) or as often as the Pledgee shall reasonably
      require. A more frequent delivery of pledge lists shall be deemed to occur
      at the Pledgee's request.

3.    Representations and Warranties

      The Pledgor represents and warrants to the Pledgee that:

      (i)   it has power ("beschikkingsbevoegdheid") to pledge the Receivables;

      (ii)  the Receivables are duly and validly existing;

      (iii) the Receivables are not subject to any attachments ("beslag"), nor
            are there any limited rights ("beperkte rechten") levied thereon or
            vested therein for the benefit of third parties, other than in
            accordance with clause 5.2 of the Agreements;

      (iv)  it has not previously and/or in advance transferred or created or
            promised to transfer or create, limited property rights on or
            against any of the Receivables, or any part thereof, to or in favour
            of third parties, other than in accordance with clause 5.2 of the
            Agreements;

      (v)   the Receivables are capable of being pledged in the manner set out
            herein.

4.    Ranking

                                                                           E-140
<PAGE>

                                                           Stibbe Draft 10/07/02

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Ancillary Rights

      The Receivables are pledged together with all rights, including dependent
      and ancillary rights, privileges and rights of actions attached thereto.
      Insofar as necessary, the Pledgor hereby irrevocably authorises the
      Pledgee to exercise these rights on its behalf. The Pledgee is released
      from the formality of protesting endorsable commercial paper.

6.    Covenants

6.1   The Pledgor shall at all times supply and provide to the Pledgee at its
      first request all evidence and documents relating to the Receivables and
      all information and assistance which the Pledgee may deem reasonably
      necessary for the exercise of its rights pursuant hereto.

6.2   The Pledgor shall, if so requested, allow the Pledgee regular examination
      of its debtor administration and all documents related thereto.

6.3   Insofar as the pledge relates to Receivables from non-Dutch debtors or
      governed by foreign law, the Pledgor further undertakes to perform all
      such acts and render all such assistance as the Pledgee may deem
      reasonably necessary based on applicable rules and regulations.

6.4   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Receivables, or an event analogous to any of the above occurring under the
      laws of any other jurisdiction.

6.5   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the
      Receivables, failing which the Pledgee shall be entitled to give such
      notice.

7.    Assignment

                                                                           E-141
<PAGE>

                                                           Stibbe Draft 10/07/02

      Subject to clause 5.2 of the Agreement, the Pledgor may not assign,
      encumber or otherwise alienate or transfer any rights in relation to the
      Receivables to third parties without the prior written consent of the
      Pledgee.

8.    Notification of Pledge

      In case the Pledgor has not fulfilled its Secured Obligations ("Event of
      Default") the Pledgee shall be entitled at all times to give notice of the
      pledge to the debtors of the Receivables.

9.    Authority to Collect

9.1   After having given notice of the pledge, the Pledgee shall be entitled to
      collect the Receivables by judicial or extrajudicial proceedings, to grant
      discharge in respect thereof, to enter into compromises, settlements and
      other agreements with the debtors of the Receivables, and to exercise all
      other rights of the Pledgor in this respect.

9.2   The Pledgee shall not, on any account whatsoever, be liable to the Pledgor
      or its successors in title for any failure to collect or to collect in
      full any of the Receivables.

9.3   All costs incurred in the collection of the Receivables shall be for the
      account of the Pledgor, even if the Pledgee for whatever reason fails to
      collect any of the Receivables or fails to do so in full.

10.   Enforcement

10.1  In case of an Event of Default, the Pledgee shall, in addition to its
      rights pursuant to clauses 8 and 9 above, be entitled to sell the
      Receivables and to recover the outstanding amount from the proceeds of
      collection pursuant to clause 9 above and/or the proceeds of sale.

10.2  In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties having limited rights in or levied attachment on any of
      the Receivables, nor shall the Pledgee be obliged to give notice of any
      sale subsequent thereto. The Pledgor hereby waives its right to apply to
      the President of the District Court for an order that the Receivables be
      sold in a manner different from that provided for in Article 3:250 of the
      Netherlands Civil Code ("NCC") and, if applicable, its rights under
      Article 3:234 of the NCC.

11.   Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Receivables, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

12.   Release of Pledge

                                                                           E-142
<PAGE>

                                                           Stibbe Draft 10/07/02

      The Pledgee shall only be held to release its pledge if, it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

13.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Receivables or the exercise of any rights vested in the Pledgee.

14.   Costs

      All cost related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

15.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

16.   Power of Attorney

16.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the
            Receivables or any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Receivables or under or in connection
            with this deed.

16.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 16.1 hereof.

17.   Severability

                                                                           E-143
<PAGE>

                                                           Stibbe Draft 10/07/02

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

18.   Amendments and Waivers

18.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

18.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

19.   Governing Law and Jurisdiction

19.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

19.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

                                         ---------------------------------------
                                         CAM Acquisition B.V.
--------------------------------
CAM IMPLANTS B.V.                        on behalf of G.A. Kok Beheer B.V.

by: Michael John Jeffries                by: Gerard Anton Kok

title: Director                          title: Director of G.A. Kok Beheer B.V.

                                                                           E-144
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX A

To:CAM IMPLANTS B.V.

                                   PLEDGE LIST

The undersigned, CAM AQCUISITION B.V., established in Zernikedreef 6, 2333 CL
Leiden, the Netherlands, pledges pursuant to the deed of pledge of receivables
dated 10 July 2002 between the undersigned and the addressee (the "Deed of
Pledge of Receivables") to you all Receivables set out in the list attached as
Schedule I to this pledge list to you. The details of this list are set out
below:

date: 9 July 2002
number of pages: 2
first debtor's name: ***
amount first Receivable:***
date first contract/number of invoice: unknown
last debtor's name: ***
amount last Receivable:***
date last contract/number of invoice: unknown
total Receivables:***
outstanding as per before 9 July 2002

Capitalized terms used in this pledge list have, unless expressly defined
otherwise herein, the same meaning as in the Deed of the Pledge of Receivables.

The undersigned hereby represents and warrants that the matters set out in
Clause 3 of the Deed of Pledge of Receivables are true and correct as at the
date hereof with regard to the Receivables pledged hereby.

Copies of invoices, contracts, and/or other relevant documentation such as
delivery receipts associated with these receivables are held at your disposal.

--------------------------------------
CAM Acquisition B.V.

on behalf of G.A. Kok Beheer B.V.

by: Gerard Anton Kok

title: Director of G.A. Kok Beheer B.V.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-145
<PAGE>

                                                           Stibbe Draft 10/07/02

                               45: CAM Implants BV
                          Aged Debt Report by Due Date
                          Division: 45 CAM Implants BV.
                      in Base Currency: EUR: Euro Currency

<TABLE>
<CAPTION>
                      Total           1-Jun-2002 to       1-May to       1-Apr to       1-Mar to           Before           In
                   Outstanding         9-JUL-2002       31-May 2002    30-Apr 2002      31-Mar 20        28-Feb 2002      Dispute
                   -----------         ----------       -----------    -----------      ---------        -----------      -------
<S>                <C>               <C>                        <C>            <C>            <C>               <C>              <C>
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***

TOTAL for
Currency: EUR      ***                                          ***            ***            ***               ***              ***
</TABLE>

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-146
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 10 - DEED OF PLEDGE OF INTELLECTUAL PROPERTY RIGHTS

This deed is entered into on the 10th day of July 2002

BETWEEN:

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

HAVE AGREED AS FOLLOWS:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Existing IP Rights" means the Copyrights, Database Rights, Designs,
      Licensee Rights, Internet Domain Names, Patents, Trade Marks and/or Trade
      Secrets, along with any and all income, royalties, damages and payments at
      any time due or payable to Pledgor with respect thereto, including without
      limitation damages and payments for past or future infringements or
      misappropriations thereof, in any state or country, and all including,
      without limitation, the (pending) trademarks attached hereto as Annex A,
      all rights with respect to the patents and patent applications listed in
      Annex B, the internet domain name

                                                                           E-147
<PAGE>

                                                           Stibbe Draft 10/07/02

      as set out attached hereto as Annex C, or otherwise existing at the time
      of execution of this Agreement;

      "Future IP Rights" means any and all Copyrights, Database Rights, Designs,
      Licensee Rights, Internet Domain Names, Patents, Trade Marks and/or Trade
      Secrets, along with any and all income, royalties, damages and payments at
      any time due or payable to Pledgor with respect thereto, including without
      limitation damages and payments for past or future infringements or
      misappropriations thereof, in any state or country, applied for, granted
      to, acquired or owned by Pledgor subsequent to the execution of this
      Agreement;

      "Copyrights" means any and all copyrights, whether registered or not,
      within the meaning of (i) the Dutch Copyright Act (Auteurswet), (ii) the
      Convention of Bern, (iii) the Universal Copyright Convention, or (iv) any
      similar, present or future, legal regime, and including any pending
      applications for such rights (to the extent relevant under Applicable
      Law), in The Netherlands and/or in any other state or country, owned by
      Pledgor;

      "Database Rights" means any and all rights, whether registered or not, in
      databases within the meaning of (i) the Dutch Database Act
      (Databankenwet), (ii) the Directive 96/9/EC of the European Parliament and
      of the Council of 11 March 1996 on the legal protection of databases or
      (iii) any similar, present or future, legal regime, and including any
      pending applications for such rights (to the extent relevant under
      Applicable Law), in The Netherlands and/or in any other state or country,
      owned by Pledgor;

      "Designs" means any and all rights, whether registered or not, in designs
      within the meaning of (i) the Uniform Benelux Designs Act (Eenvormige
      Beneluxwet inzake Tekeningen of Modellen), (ii) the Directive 98/71/EC of
      the European Parliament and of the Council of 13 October 1998 on the legal
      protection of designs or (iii) any similar, present or future, legal
      regime, and including any pending applications for such rights (to the
      extent relevant under Applicable Law), in The Netherlands, the Benelux
      and/or any other state or country, owned by Pledgor;

      "Internet Domain Names" means any and all rights, whether registered or
      not, in internet domain names, and including any pending applications for
      such rights (to the extent relevant under Applicable Law), in the name of
      Pledgor, in The Netherlands and/or in any other state or country;

      "Licensee Rights" means any and all rights of Pledgor, whether registered
      or not, pursuant to any licence agreements, whether written or oral, with
      third parties by which Pledgor has obtained rights (of whatever nature) to
      use, copy, distribute, market, sub-license, sell or otherwise exploit or
      apply any and all Copyrights, Database Rights, Designs, Patents, Trade
      Marks and/or Trade Secrets, in The Netherlands and/or in any other state
      or country, as well as any rights or permits of Pledgor in connection with
      any Internet Domain Names, all to the extent that such licence agreements
      do not prohibit Pledgor to grant a right of pledge on their respective
      rights thereunder;

                                                                           E-148
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Patents" means any and all rights, whether registered or not, in patents
      within the meaning of (i) the Dutch Patent Acts of 1910 or 1995,
      respectively, (Rijksoctrooiwet 1910 of Rijksoctrooiwet 1995), (ii) the
      European Patent Convention of 1973, (iii) the Patent Cooperation Treaty of
      1970 or (iv) any similar, present or future, legal regime, whether
      registered or not, and including any pending applications for such rights
      (to the extent relevant under Applicable Law), in The Netherlands and/or
      in any other state or country, owned by the Pledgor;

      "Trade Marks" means any and all rights, whether registered or not, in
      trade marks and trade names and all goodwill associated therewith, within
      the meaning of (i) the Benelux Trade Mark Act (Benelux Merkenwet), (ii)
      the Dutch Trade Names Act (Handelsnaamwet), (iii) EU Council Regulation
      (EC) No 40/94 on the Community trade mark or (iv) any similar, present or
      future, legal regime, whether registered or not, and including any pending
      applications for such rights (to the extent relevant under Applicable Law,
      in The Netherlands and/or in any other state or country, owned by Pledgor;

      "Trade Secrets" means any and all rights, whether registered or not, in
      trade secrets and all non-public information or confidential information,
      (including, without limitation, inventions, discoveries, improvements,
      customer lists, know-how and ideas) whether registered or not, and
      including any pending applications for such rights (to the extent relevant
      under Applicable Law), in The Netherlands and/or in any other state or
      country, owned by Pledgor;

      "Pledge Confirmation" has the meaning as defined in clause 2.2 of this
      deed of pledge;

      "Rights" means collectively the Existing IP Rights and the Future IP
      Rights;

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Event of Default" has the meaning as defined in clause 2.3 of this deed
      of pledge.

2.    Pledge

2.1   As additional security for the fulfilment of the Secured Obligations and
      subject to clause 5.2 of the Agreement, the Pledgor hereby pledges
      ("Verpandt") to the Pledgee, whether or not in advance, all the Rights,
      which pledge the Pledgee hereby accepts.

2.2   Immediately after the Pledgor will have acquired Future IP Rights he will
      notify the Pledgee thereof in writing, specifying the details of such
      Future IP Rights. The Pledgor will then also execute a notice of
      confirmation substantially in the form of Annex D hereto (the "Pledge
      Confirmation") to confirm that such Future IP Rights are thereby pledged
      to the Pledgee on the terms and conditions set out in this deed of pledge.
      The Pledgee will accept the pledge of the Future IP Rights specified in
      the Pledge Confirmation by signing the Pledge Confirmation for acceptance
      and returning it to the Pledgor. The Pledgor shall upon receipt of the
      signed Pledge Confirmation from the Pledgee submit it to the relevant
      authorities to obtain registration of the pledge.

                                                                           E-149
<PAGE>

                                                           Stibbe Draft 10/07/02

2.3   The Rights are pledged to the Pledgee with all privileges connected
      therewith and all other rights ancillary thereto ("afhankelijke en
      nevenrechten"). Insofar necessary the Pledgor hereby irrevocably
      authorises and gives power of attorney to the Pledgee to exercise such
      rights on behalf of the Pledgor following the occurrence and during the
      continuation of a situation that the Pledgor has not fulfilled or paid its
      Secured Obligations ("Event of Default").

3.    Registration

3.1   The creation of the rights of pledge on the Rights created hereby or to be
      created under or pursuant to this deed of pledge in accordance with clause
      2.2 above is effected by the fact that the parties hereto sign this deed.

3.2   The rights of pledge on the IP Rights and the Future IP Rights created
      hereunder will have effect against third parties by the subsequent
      registration of this deed of pledge and the relevant Pledge Confirmations
      at the relevant national and international authorities.

3.3   The Pledgor hereby irrevocably appoints the Pledgee and any person
      nominated by the Pledgee in its name and on its behalf and expense to
      register, record or file this deed of pledge and Pledge Confirmations with
      the relevant authorities and any further registers or offices where the
      right of pledge created hereby, in the reasonable opinion of the Pledgee,
      requires to be registered, recorded or filed.

3.4   For purposes of Article 40 (2) of the Netherlands Patent Act 1910 and of
      Article 67 (2) of The Netherlands Patent Act 1995 the Pledgee hereby
      chooses domicile at the Bureau Industriele Eigendom, The Hague, the
      Netherlands, or at such office as may be designated in the future in the
      Netherlands Patent Act for similar purposes.

4.    Protection of Rights

4.1   Without prejudice to the Pledgor's obligations under this deed of pledge,
      the Pledgor hereby authorises the Pledgee (such authorisation not meaning
      that the Pledgee is obliged to take any of the following actions), and for
      the purposes thereof the Pledgor hereby gives, on the condition precedent
      of the occurrence of an Event of Default, full power of attorney to the
      Pledgee and any person nominated by the Pledgee, to take in the Pledgor's
      name and on the Pledgor's behalf and expense, all actions deemed necessary
      by the Pledgee to fully protect or perfect the rights of pledge granted
      hereunder and to take in the Pledgor's name and on the Pledgor's behalf
      and expense, all actions deemed necessary by the Pledgee to fully protect
      the Rights and to fully protect or perfect the rights of pledge granted
      hereunder, including but not limited to timely renewing the Rights in the
      registers, paying the fees of registration and instituting legal
      proceedings and the signing, at any time, on its behalf of Pledge
      Confirmations substantially in the form of Annex D hereto. The Pledgor
      shall promptly notify the Pledgee in writing of any issues that arise with
      regard to the protection of the Rights and provide any assistance the
      Pledgee reasonably requests. In connection with the power of attorney
      contained in this clause the Pledgor waives his rights pursuant to Article
      3:68 of the Netherlands Civil Code ("NCC"), which waiver the Pledgee
      hereby accepts.

                                                                           E-150
<PAGE>

                                                           Stibbe Draft 10/07/02

4.2.  The Pledgor hereby covenants at the Pledgee's first request (i) to execute
      such other instruments, deeds, forms or agreements, choice of domicile,
      (ii) make or cause to be made such further recordings, registrations or
      filings, or (iii) take or cause to be taken such further action as the
      Pledgee will deem necessary or advisable to (further) perfect or protect
      the rights of pledge of the Rights created hereby in all countries where
      the Rights are registered or effective from time to time.

4.3   The Pledgor shall retain possession of evidence of the normal, adequate
      and proper use that was made or is being made of the trademarks listed in
      Annex A. This evidence includes, but is not limited to, samples of
      products, packaging, promotional material and copies of some invoices to
      customers, containing the registered trademark. The Pledgor shall forward
      this evidence of use to the Pledgee upon the Pledgee's first request.

5.    Representations and Warranties

5.1   The Pledgor hereby represents, warrants and declares to the Pledgee that:

      (i)   to the best of its knowledge, it is the exclusive proprietor of, and
            has power ("beschikkingsbevoegdheid") to pledge, the Rights and that
            there are no attachments ("beslagen") and there are not and will not
            be any security interests or limited rights ("beperkte rechten")
            levied thereon or vested therein for the benefit of third parties
            other than in accordance with clause 5.2 of the Agreement, nor any
            right of retention ("retentierecht") on or against the Rights;

      (ii)  it makes and will make normal use of the trademarks listed in Annex
            A and will continue to use all trademarks in conformity with the
            registration thereof;

      (iii) it has not previously and/or in advance transferred or created
            limited rights ("beperkte rechten") in or against the Rights either
            in whole or in part, to or in favour of third parties other than in
            accordance with clause 5.2 of the Agreement;

      (iv)  to the best of its knowledge, this deed of pledge constitutes the
            legal, valid and binding obligations of the Pledgor; and;

      (v)   it has full power, authority and legal right to execute, deliver and
            perform his obligations under this deed of pledge and to pledge the
            Rights pursuant to this deed of pledge, and the execution, delivery
            and performance hereof and the pledge of and grant of a security
            interest in the Rights hereunder have been duly authorised by all
            necessary corporate or other action and do not contravene any law,
            rule or regulation or any provision of the Pledgor's charter
            documents or by-laws or of any judgment, decree or order of any
            tribunal or of any agreement or instrument to which the Pledgor is a
            party or by which it or any of its property is bound or affected or
            constitute a default thereunder.

5.2   The representations and warranties in clause 5.1 above shall be deemed to
      be repeated by the Pledgor on each of the dates on which a Pledge
      Confirmation is executed by the Pledgor, as if made with reference to the
      facts and circumstances then existing and with reference to the Rights
      contained in all Pledge Confirmations.

                                                                           E-151
<PAGE>

                                                           Stibbe Draft 10/07/02

6.    Ranking

      Subject to clause 5.2 of the Agreement, the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge

7.    Covenants

7.1   Subject to clause 3.6 of the Agreement, the The Pledgor has submitted or
      shall submit respectively declares to have submitted all necessary
      documents to the relevant registers to achieve proper and valid
      registration of the Rights in his name.

7.2   The Pledgor undertakes to timely renew the registrations of the Rights in
      order to prevent the lapsing or expiration of these rights and the
      registration thereof at the relevant authorities.

7.3   The Pledgor shall notify the Pledgee immediately of all circumstances that
      could affect the Pledgee's interests. Such circumstances shall include,
      without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes and social security premiums or planning to notify to the relevant
      authorities thereof, an attachment being levied on some or all of the
      Rights, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

7.4   The Pledgor declares that, after the occurrence and during the
      continuation of an Event of Default, in all actual or legal disputes,
      concerning the Rights, it will act in accordance with instructions to be
      given by the Pledgee.

7.5   The Pledgor shall defend the rights and security interests of the Pledgee
      in the Rights against any claims and demands of any third parties.

8.    Alienation, Use

8.1   Subject to clause 5.2 of the Agreement, the Pledgor may not alienate,
      encumber, license or otherwise grant the use of the Rights to third
      parties without the prior written consent of the Pledgee.

9.    Enforcement

                                                                           E-152
<PAGE>

                                                           Stibbe Draft 10/07/02

9.1   Without prejudice to the rights and remedies provided to the Pledgee by
      law and subject to the mandatory rules of law, the Pledgee shall be
      entitled, in case of an Event of Default, to take all measures, whether
      judicial or extra-judicial, which a Pledgee may take in the event of
      execution of the pledged rights and which are permitted by law and which
      in his opinion are required in his interests, including without
      limitation, the sale of the Rights and the recovery of the outstanding
      amount from the proceeds of the sale.

9.2   In case of an Event of Default, the Pledgee shall be under no obligation
      to inform the Pledgor, or any third party having limited rights ("beperkte
      rechten") in or levied attachment on or against all or any part of the
      Rights, of its intention to collect or foreclose thereon. The Pledgor
      hereby waives its right to apply to the President of the District Court
      for an order that the Rights be sold in a manner different from that
      provided for in Article 3:250 NCC, and, if applicable, its rights under
      Article 3:234 NCC, which waiver is hereby accepted by the Pledgee.

9.3   The Pledgee shall not be liable to the Pledgor or its successors in
      interest for any damages caused by the sale of the Rights, gross
      negligence and wilful misconduct excepted.

10.   Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Rights, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

11.   Release of Pledge

      The Pledgee shall only be held to release its pledge if it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

12.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Rights or the exercise of any rights vested in the Pledgee.

13.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extra-judicial exercise by the Pledgee of its rights hereunder
      (i.e. foreclosure), including legal fees and costs of litigation, shall be
      borne by the Pledgor.

                                                                           E-153
<PAGE>

                                                           Stibbe Draft 10/07/02

14.   No nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

15.   Power of Attorney

15.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Rights or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Rights or under or in connection with
            this deed.

15.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

16.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

17.   Amendments and Waivers

17.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

17.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

18.   Governing Law and Jurisdiction

18.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

                                                                           E-154
<PAGE>

                                                           Stibbe Draft 10/07/02
18.2  All disputes arising out of this deed of pledge shall be submitted to the
      competent court in Amsterdam, the Netherlands. Nothing in the preceding
      sentence shall limit the Pledgee's right to bring proceedings against the
      Pledgor in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

--------------------------------         ---------------------------------------
CAM IMPLANTS B.V.                        CAM Acquisition B.V.

by: Michael John Jeffries                on behalf of G.A. Kok Beheer B.V.

title: Director                          by: Gerard Anton Kok

                                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-155
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX A - Trademarks and Trademark Applications

1.    The product names, including all their registrations and pending
      applications, "CAMCERAM" and "TAM".

2.    The company name "CAM Implants B.V.", including its registration
      certificate at the "Benelux Merkenbureau" (CAM document nr. 23).

                                                                           E-156
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX B - Patents and Pending Patent Applications

<TABLE>
<CAPTION>
Atty Case#          Title                          Owner         Issued Patent #    Issue Date
-------------------------------------------------------------------------------------------------
<S>                 <C>                            <C>           <C>                <C>
525400-153          Spherical Hydroxyapatite       CAM           5,702,677          12/30/1997
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-183          Spherical Hydroxyapatite       CAM           001032             8/28/2000
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-182          Spherical Hydroxyapatite       CAM           69708870.7-08      5/12/2001

PCT Germany         Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-175          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-181          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-182          Spherical Hydroxyapatite       CAM           0910546            12/5/2001
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-185          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

285-144             Calcium Phosphate Graft        CAM           0
                    Material, Process for Making   Acquisition
                    Same and Osteoimplant          B.V.
                    Fabricated From Same

285-144 PCT         Calcium Phosphate Graft        CAM           0
                    Material, Process for Making   Acquisition
                    Same and Osteoimplant          B.V.
                    Fabricated From Same

<CAPTION>
Atty Case#              Filing Date   Serial Number           Inventors           Country
--------------------------------------------------------------------------------------------
<S>                     <C>           <C>                     <C>                 <C>
525400-153              7/10/1996     679,611                 Shimp, Renkema      U.S.

525400-183              6/20/1997     199900055               Shimp, Renkema      Eurasia

525400-182              6/20/1997     35175                   Shimp, Renkema      Germany

PCT Germany

525400-175              6/20/1997     PCT/US97/16031          Shimp, Renkema      PCT

525400-181              12/03/1998    2,257,290               Shimp, Renkema      Canada

525400-182              6/20/1997     97941008.1              Shimp, Renkema      EPO

525400-185              6/20/1997     PCT 710915/98           Shimp, Renkema      Korea

285-144                 12/15/2000    09/737,369              Shimp               U.S.

285-144 PCT             12/15/2000    PCT/US00/33985          Shimp               PCT
</TABLE>

                                                                           E-157
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX C - Internet Domain Names

The registration of the existing Internet domain www.camimplants.nl and all
rights and obligations adhering to it.

                                                                           E-158
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX D - Pledge Confirmation

[Patent or Trade Mark Register]
[Address]
[Place]
[Date]

Dear Sirs,

Pledge of IP rights

We hereby inform you that pursuant to the deed of pledge of IP Rights dated 9
July 2002 (the "Deed of Pledge") a first-ranking right of pledge on all of its
present and future intellectual property rights was created by CAM Acquisition
B.V. in favour of CAM IMPLANTS B.V. (hereinafter referred to as the Pledgee), a
corporation incorporated and existing under the laws of the Netherlands, with
corporate seat and having its registered office at Zernikedreef 6, 2333 CL,
Leiden, the Netherlands, the Netherlands.

This is to confirm that on [date] CAM Acquisition B.V. has acquired IP Rights,
particulars of which are set forth in the annex to this letter. CAM Acquisition
B.V., in order to secure the prompt performance and payment in full of the
Secured Obligations, hereby pledges ("verpandt") these IP Rights listed in the
annex to this letter to CAM IMPLANTS B.V. on the terms and conditions as set out
in the Deed of Pledge.

For purposes of Article 40 (2) of the Netherlands Patent Act 1910 and of Article
67 (2) of The Netherlands Patent Act 1995 the Pledgee, insofar necessary, hereby
chooses domicile at the Bureau lndustriele Eigendom in The Hague.

Yours sincerely,

CAM Acquisition B.V. (authorised signatories)

                                                                           E-159
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 11 - PRELIMINARY BALANCE SHEET

Current Assets:
Cash                                                                        ***
Accounts Receivable, Net                                                    ***
Inventories                                                                 ***
Prepaid Expenses and Other Current Assets                                   ***
                                                                 ---------------
Total Current Assets                                                        ***

Due from Any Other Group Company                                            ***
Due from Any Other Group Company                                            ***

Property and Equipment, Net                                                 ***
Intangible Assets, Net                                                      ***
                                                                 ---------------
Total Assets                                                                ***
                                                                 ===============
Current Liabilities
Accounts Payable and Accrued Liabilities                                    ***

Due to Any Other Group Company                                              ***
                                                                 ---------------
Total Liabilities                                                           ***

Total Stockholder's Equity                                                  ***
                                                                 ---------------
Total Liabilities And Stockholder's Equity                                  ***
                                                                 ===============

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-160
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 12 - DISCLOSURE LETTER

CAM IMPLANTS B.V.
Zernikedreef 6
2333 CL Leiden
The Netherlands

Bilthoven, 10 July 2002

Re: Disclosure Letter

Dear Sirs,

This letter is addressed to you as the "Disclosure Letter" pursuant to clause
2.5 (e) of the Asset Purchase Agreement. Please sign this letter on behalf of
CAM IMPLANTS B.V. for approval.

The following liabilities are excluded from the sale and transfer contemplated
by the Asset Purchase Agreement of which this letter is a Schedule:

      1.    Any and all liabilities of the Seller to any other Group Companies
            already existing or yet to arise.

      2.    Any and all product liabilities ensuing from claims filed or to be
            filed by one or more Group Companies or one or more third parties
            against the Seller, including but not limited to the existing claim
            filed by former customer the "O' Company".

      3.    Any and all liability for or in connection with corporate income tax
            paid or payable by Seller or any other entity over the period prior
            to the Closing Date.

      4.    Any and all liabilities and / or claims made against Seller, arising
            from or in regard of any action, occurrence, or otherwise during the
            period prior to the date of appointment of Gerard Anton Kok as
            director of CAM IMPLANTS B.V.

Yours sincerely,

---------------------------------------
Gerard Anton Kok

Approved on behalf of CAM IMPLANTS B.V.

---------------------------------------
Michael John Jeffries

                                                                           E-161
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 13 - OSTEOTECH PATENTS

<TABLE>
<CAPTION>
Atty Case#          Title                          Owner         Issued Patent #
-----------------------------------------------------------------------------------
<S>                 <C>                            <C>           <C>
525400-153          Spherical Hydroxyapatite       Osteotech     5,702,677
                    Particles and Process for
                    the Production Thereof

525400-183          Spherical Hydroxyapatite       Osteotech     001032
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     69708870.7-08

PCT Germany         Particles and Process for
                    the Production Thereof

525400-175          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-181          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     0910546
                    Particles and Process for
                    the Production Thereof

525400-185          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

285-144             Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

285-144 PCT         Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

<CAPTION>
Atty Case#           Issue Date    Filing Date   Serial Number           Inventors           Country
-------------------------------------------------------------------------------------------------------
<S>                  <C>           <C>           <C>                     <C>                 <C>
525400-153           12/30/1997    7/10/1996     679,611                 Shimp, Renkema      U.S.

525400-183           8/28/2000     6/20/1997     199900055               Shimp, Renkema      Eurasia

525400-182           5/12/2001     6/20/1997     35175                   Shimp, Renkema      Germany

PCT Germany

525400-175                         6/20/1997     PCT/US97/16031          Shimp, Renkema      PCT

525400-181                         12/03/1998    2,257,290               Shimp, Renkema      Canada

525400-182           12/5/2001     6/20/1997     97941008.1              Shimp, Renkema      EPO

525400-185                         6/20/1997     PCT 710915/98           Shimp, Renkema      Korea

285-144                            12/15/2000    09/737,369              Shimp               U.S.

285-144 PCT                        12/15/2000    PCT/US00/33985          Shimp               PCT

</TABLE>

                                                                           E-162
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 14 - DEED OF ASSIGNMENT AND LICENSE

This Deed is made and entered into by and between the following Parties:

1.    OSTEOTECH INC, a company duly organized and existing under the laws of the
      State of New Jersey, having its registered office at 51 James Way, Eaton
      Town, New Jersey, USA, hereinafter referred to as "the Assignor";

and

2.    CAM ACQUISITION B.V., a company duly organized and existing under the laws
      of The Netherlands, having its registered office at Zernikedreef 6, 2333
      CL, Leiden, the Netherlands, hereinafter referred to as "the Assignee";

WHEREAS:

-     Assignor is the proprietor of the patents and patent applications as set
      forth in Annex I hereto (hereinafter "the Patents");

-     The Assignee has entered into an Asset Purchase Agreement with CAM
      Implants B.V., in connection with which the Assignee is interested in
      obtaining rights, title and interest in the Patents;

-     The Assignor has agreed to assign the Patents to Assignee for 1 US$, but
      to remain entitled, under a royalty free license, to exclusively use the
      Patents in developing and marketing bone tissue products in combination
      with calcium phosphate for application in orthopaedic procedures.

NOW THEREFORE, in consideration of the mutual covenants, promises and
undertakings set forth herein, the Parties hereby agree as follows:

      Transfer and assignment

1.    The Assignor hereby assigns and transfers to the Assignee any and all
      rights, title and interest in the Patents, free and unencumbered. Assignee
      hereby accepts such rights, title and interest in the Patents.

2.    The Assignee acquires the Patents from the Assignor for a total
      consideration of 1 US$.

3.    The Assignor shall make, do or execute all documents, acts, matters or
      writings which the Assignee deems necessary or desirable to give full
      effect to the provisions of this Deed. For that purpose this Deed or
      extracts thereof may be registered with the relevant patent office(s).

      For the event that for any part of any of the Patents this Deed would not
      fully constitute full transfer and assignment of any and all rights, title
      and interest and additional requirements would apply to that effect, the
      Assignor hereby grants to Assignee, and Assignee hereby accepts, the
      unlimited, worldwide, perpetual, royalty-free exclusive

                                                                           E-163
<PAGE>

                                                           Stibbe Draft 10/07/02

      license to use and exploit such Patents as of the date of undersigning
      this Deed until any and all such additional requirements for full transfer
      and assignment have been executed and effectuated.

      License

4.    The Assignee hereby grants the Assignor a worldwide, royalty free and
      exclusive license, with the right to sub-license, under the Patents to
      develop, manufacture, have manufactured, market, sell, offer to sell and
      import bone tissue products in combination with calcium phosphate for
      application in orthopaedic procedures (hereinafter referred to as: the
      License). The Assignor hereby accepts the License.

5.    The License covers the entire duration of the period during which any
      right could or can be derived from the Patents, and cannot be prematurely
      terminated.

6.    During the term of the License, the Assignee shall not be entitled to use
      the Patents to develop, manufacture, have manufactured, market, sell,
      offer to sell and import bone tissue products in combination with calcium
      phosphate for application in orthopaedic procedures.

7.    The parties hereto agree to execute such formal documents as may be
      required for the purpose of registering the abovementioned licence in the
      relevant countries.

8.    The Assignee agrees, for the duration of the License, to sell under normal
      business conditions, and if available in the ordinary course of business,
      to the Assignor, at its request, calcium phosphate and calcium phosphate
      products, at prices no less favourable then the best price offered to
      comparable customers of the Purchaser for such quantities.

9.    The assignee agrees and warrants that it shall pay any and all applicable
      fees and that it shall do and omit all such other acts as may from time to
      time be necessary and/or appropriate to have the Patents issued
      and/orfully maintained for the designated territories as set forth in
      Annex I hereto (including but not limited to defending and prosecuting the
      Patents).

10.   Without any prejudice to clause 11, the License includes the right of the
      Assignor to -- at its own discretion -- defend and prosecute the Patents
      against claims of third parties and/or possible infringements by third
      parties, including but not limited to the right to initiate proceedings
      against such third parties in its own name and/or -- if the Assignor deems
      it necessary or desirable -- in the name of the Assignee.

11.   The Assignee shall procure and warrants that the License shall survive any
      assignment and/or encumberment of the Patents.

      Miscellaneous

12.   The Assignor shall render to the Assignee, at the Assignee's first
      request, any reasonable assistance which the Assignee deems necessary or
      desirable to defend or prosecute any of

                                                                           E-164
<PAGE>

                                                           Stibbe Draft 10/07/02

      the Patents, provided that any and all reasonable costs and expenses of
      the Assignor shall be reimbursed by the Assignee.

13.   Parties must inform each other immediately of any actions by third parties
      suspected of infringing the Patents, and in the event third parties claim
      infringement by the Patents.

14.   Each Party shall use and exploit the Patents for its own risk and account,
      and indemnifies and holds the other Party harmless against any and all
      claims, losses, damages, liabilities and expenses arising out of or
      relating to any claim of third parties in that respect.

15.   This Deed shall in all respects be exclusively governed by and deemed to
      have been construed in accordance with the laws of The Netherlands.

16.   Any dispute or claim arising out of or in connection with this Deed shall
      be referred to and exclusively and finally settled by the competent court
      in The Hague, The Netherlands.

--------------------------------         ---------------------------------------
CAM IMPLANTS B.V.                        CAM Acquisition B.V.

by: Michael John Jeffries                on behalf of G.A. Kok Beheer B.V.

title: Director                          by: Gerard Anton Kok

                                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-165
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX I - Patents and Pending Patent Applications

<TABLE>
<CAPTION>
Atty Case#          Title                          Owner         Issued Patent #
-----------------------------------------------------------------------------------
<S>                 <C>                            <C>           <C>
525400-153          Spherical Hydroxyapatite       Osteotech     5,702,677
                    Particles and Process for
                    the Production Thereof

525400-183          Spherical Hydroxyapatite       Osteotech     001032
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     69708870.7-08

PCT Germany         Particles and Process for
                    the Production Thereof

525400-175          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-181          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     0910546
                    Particles and Process for
                    the Production Thereof

525400-185          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

285-144             Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

285-144 PCT         Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

<CAPTION>
Atty Case#              Issue Date    Filing Date   Serial Number           Inventors           Country
-------------------------------------------------------------------------------------------------------------
<S>                     <C>           <C>           <C>                     <C>                 <C>
525400-153              12/30/1997    7/10/1996     679,611                 Shimp, Renkema      U.S.

525400-183              8/28/2000     6/20/1997     199900055               Shimp, Renkema      Eurasia

525400-182              5/12/2001     6/20/1997     35175                   Shimp, Renkema      Germany

PCT Germany

525400-175                            6/20/1997     PCT/US97/16031          Shimp, Renkema      PCT

525400-181                            12/03/1998    2,257,290               Shimp, Renkema      Canada

525400-182              12/5/2001     6/20/1997     97941008.1              Shimp, Renkema      EPO

525400-185                            6/20/1997     PCT 710915/98           Shimp, Renkema      Korea

285-144                               12/15/2000    09/737,369              Shimp               U.S.

285-144 PCT                           12/15/2000    PCT/US00/33985          Shimp               PCT

</TABLE>

                                                                           E-166
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 15 - OTHER CURRENT ASSETS

Prepaid expenses and other assets as of March 31, 2002:

          Prepaid Insurance                                                  ***
          Prepaid rent/lease                                                 ***
          Prepaid maintenance                                                ***
          Prepaid freight                                                    ***
          Prepaid Pension                                                    ***
          Prepaid Wao/ ZW                                                    ***
          Prepaid Other                                                      ***
                                                                     -----------
                   Total                                                     ***
                                                                     ===========

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-167
<PAGE>

                                                           Stibbe Draft 10/07/02

SHAREHOLDERS' RESOLUTION

CAM IMPLANTS B.V.

The undersigned:

HC Implants B.V., a corporation duly organized and existing under the laws of
the Netherlands, having its registered office at Zernikedreef 6, 2333 CL,
Leiden, the Netherlands, which is being represented by a member of its
management board:

first name:                         Michael John
surname:                            Jeffries
address:                            Shrewbury Avenue 1151 E
postal code and city/town:          07702 Shrewbury, New Jersey, USA

whereas:

o     the undersigned is holder of the entire issued capital of the company with
      limited liability (besloten vennootschap met beperkte aansprakelijkheid)
      CAM IMPLANTS B. V., having its seat in Leiden, its address at Zernikedreef
      6, 2333 CL, Leiden, the Netherlands (the `Company');

o     the Management Board of the Company has been given the opportunity to cast
      its advisory vote with regard to the proposal as referred to hereinafter,
      in accordance with article 19;

o     article 17 sub 6 of the articles of association of the Company authorises
      shareholders to adopt resolutions outside a formal meeting;

o     the Company intends sell and transfer certain of its assets and certain of
      its liabilities to Cam Acquisition B. V. in accordance with the draft
      Asset Purchase Agreement, dated 3 July 2002, of which a copy is attached
      to this Shareholders' Resolution.

resolve herewith:

to approve the execution by the Company of the Asset Purchase Agreement
including the Schedules thereto and the performance of the Company's obligations
there under.

Signed in: Amsterdam on _____________

HC Implants B.V.

--------------------------
By: Michael John Jeffries

                                                                           E-168
<PAGE>

                                                           Stibbe Draft 10/07/02

SCHEDULE 17

CAM IMPLANTS B.V.
Zernikedreef 6
2333 CL Leiden
The Netherlands

Bilthoven, 10 July 2002

Re:   Resignation as director of CAM IMPLANTS B.V.

Dear Sirs,

Please be informed that, in view of the pending sale and transfer of the
majority of the assets and liabilities CAM IMPLANTS B.V. to CAM Acquisitions
B.V., I hereby resign as statutory director and as member of the management
board of CAM IMPLANTS B.V. as per the end of business on 9 July 2002.

Kindly arrange for my resignation to be filed with the trade register of the
Chamber of Commerce.

In view of the discharge to be granted by HC Implants B.V. as shareholder of CAM
IMPLANTS B.V. in relation to the fulfilment of my tasks as a director of CAM
IMPLANTS B.V., I waive any claims that I may have in the future in connection
with the past performance of my duties as managing director of CAM IMPLANTS B.V.

Yours sincerely,

G.A. Kok

                                                                           E-169
<PAGE>

                                                           Stibbe Draft 10/07/02

                               DEED OF ASSIGNMENT

This Deed is made and entered into by and between the following Parties:

1.    CAM IMPLANTS B.V., a company duly organized and existing under the laws of
      the Netherlands, having its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, duly represented by Michael John Jeffries,
      hereinafter referred to as the "Assignor";

and

2.    CAM ACQUISITION B.V., a company duly organized and existing under the laws
      of the Netherlands, having its registered office at Zernikedreef 6, 2333
      CL, Leiden, the Netherlands, duly represented by Gerard Anton Kok on
      behalf of G.A. Kok Beheer B.V., hereinafter referred to as the "Assignee";

WHEREAS:

-     Assignor is the proprietor of copyrights, database rights, designs,
      internet domain names, licensee rights, patents, trademarks, tradenames
      and/or trade secrets, along with any and all income, royalties, damages
      and payments at any time due or payable to Assignor with respect thereto,
      including without limitation damages and payments for past or future
      infringements or misappropriations thereof, in any state or country,
      (hereinafter: the "IP Rights"). The IP Rights include, but are not limited
      to, the rights and/or items as set forth in Annex I;

-     Assignor is the proprietor of any and all rights in the registrations as
      set forth in Annex II (hereinafter: the "Registration Rights" and together
      with the IP Rights jointly referred to as the "Rights")

-     The Assignee has entered into an Asset Purchase Agreement with Assignor in
      connection with which the Assignee is entitled to obtain any and all
      rights, title and interest in the Rights;

NOW THEREFORE, in consideration of the mutual covenants, promises and
undertakings set forth herein, the Parties hereby agree as follows:

      Transfer and assignment

1.    The Assignor hereby assigns and transfers to the Assignee any and all
      rights, title and interest in the Rights, free and unencumbered. Assignee
      hereby accepts such rights, title and interest in the Rights.

2.    The Assignee acquires the Rights from the Assignor for a total
      consideration of EUR 1,-.

3.    The Assignor shall make, do or execute all documents, acts, matters or
      writings which the Assignee deems necessary or desirable to give full
      effect to the provisions of this Deed.

                                                                           E-170
<PAGE>

                                                           Stibbe Draft 10/07/02

      For that purpose this Deed or extracts thereof may be registered with the
      relevant registration office(s).

      For the event that for any part of any of the IP Rights this Deed would
      not fully constitute full transfer and assignment of any and all rights,
      title and interest and additional requirements would apply to that effect,
      the Assignor hereby grants to Assignee, and Assignee hereby accepts, the
      unlimited, worldwide, perpetual, royalty-free exclusive license to use and
      exploit such IP Rights as of the date of undersigning this Deed until any
      and all such additional requirements for full transfer and assignment have
      been executed and effectuated.

      Miscellaneous

4.    The Assignor warrants that it is the owner of the Rights and that third
      parties do not have any direct or indirect rights, titles or interests in
      the Rights or in relation thereto.

5.    The Assignor states to its best knowledge that it is not aware of any
      wrongful use by any third party of the Rights and the Assignor furthermore
      states that to its best knowledge the Rights are not infringing any rights
      of third parties.

6.    The Assignor shall render to the Assignee, at the Assignee's first
      request, any reasonable assistance which the Assignee deems necessary or
      desirable to defend or prosecute any of the Rights, provided that any and
      all reasonable costs and expenses of the Assignor shall be reimbursed by
      the Assignee.

7.    This Deed shall in all respects be exclusively governed by and deemed to
      have been construed in accordance with the laws of the Netherlands.

8.    Any dispute or claim arising out of or in connection with this Deed shall
      be referred to and exclusively and finally settled by the competent court
      in The Hague, the Netherlands.

This Deed has been signed in two original copies on 10 July 2002.

--------------------------------         ---------------------------------------
CAM IMPLANTS B.V.                        CAM Acquisition B.V.

by: Michael John Jeffries                on behalf of G.A. Kok Beheer B.V.

title: Director                          by: Gerard Anton Kok

                                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-171
<PAGE>

                                                           Stibbe Draft 10/07/02

Annex I

1.    The product names, including all their registrations and pending
      applications, "CAMCERAM" and "TAM".

2.    The company name "CAM Implants B.V.", including its registration
      certificate at the "Benelux Merkenbureau" (CAM document nr. 23).

Annex II

1.    The CE registration for "CAMCERAM", consisting of certificates G1 01 06
      43847 001 and G7 00 12 20268 005.

2.    THE ISO 9001-1994/ EN 46001:1093 certificate QIZ 00 01 20268 004.

3.    The FDA Master File 298.

4.    The registration of the existing internet domain www.camimplants.nl and
      all rights and obligations adhering to it.

                                                                           E-172
<PAGE>

                                                           Stibbe Draft 10/07/02

                         DEED OF ASSIGNMENT AND LICENSE

This Deed is made and entered into by and between the following Parties:

1.    OSTEOTECH INC, a company duly organized and existing under the laws of the
      State of New Jersey, having its registered office at 51 James Way, Eaton
      Town, New Jersey, USA, hereinafter referred to as "the Assignor";

and

2.    CAM ACQUISITION B.V., a company duly organized and existing under the laws
      of The Netherlands, having its registered office at Zernikedreef 6, 2333
      CL, Leiden, the Netherlands, hereinafter referred to as "the Assignee";

WHEREAS:

-     Assignor is the proprietor of the patents and patent applications as set
      forth in Annex I hereto (hereinafter: "the Patents');

-     The Assignee has entered into an Asset Purchase Agreement with CAM
      Implants B.V., in connection with which the Assignee is interested in
      obtaining rights, title and interest in the Patents;

-     The Assignor has agreed to assign the Patents to Assignee for 1 US$, but
      to remain entitled, under a royalty free license, to exclusively use the
      Patents in developing and marketing bone tissue products in combination
      with calcium phosphate for application in orthopaedic procedures.

NOW THEREFORE, in consideration of the mutual covenants, promises and
undertakings set forth herein, the Parties hereby agree as follows:

      Transfer and assignment

1.    The Assignor hereby assigns and transfers to the Assignee any and all
      rights, title and interest in the Patents, free and unencumbered. Assignee
      hereby accepts such rights, title and interest in the Patents.

2.    The Assignee acquires the Patents from the Assignor for a total
      consideration of 1 US$.

3.    The Assignor shall make, do or execute all documents, acts, matters or
      writings which the Assignee deems necessary or desirable to give full
      effect to the provisions of this Deed. For that purpose this Deed or
      extracts thereof may be registered with the relevant patent office(s).

      For the event that for any part of any of the Patents this Deed would not
      fully constitute full transfer and assignment of any and all rights, title
      and interest and additional requirements would apply to that effect, the
      Assignor hereby grants to Assignee, and Assignee hereby accepts, the
      unlimited, worldwide, perpetual, royalty-free exclusive

                                                                           E-173
<PAGE>

                                                           Stibbe Draft 10/07/02

      license to use and exploit such Patents as of the date of undersigning
      this Deed until any and all such additional requirements for full transfer
      and assignment have been executed and effectuated.

      License

4.    The Assignee hereby grants the Assignor a worldwide, royalty free and
      exclusive license, with the right to sub-license, under the Patents to
      develop, manufacture, have manufactured, market, sell, offer to sell and
      import bone tissue products in combination with calcium phosphate for
      application in orthopaedic procedures (hereinafter referred to as: the
      License). The Assignor hereby accepts the License.

5.    The License covers the entire duration of the period during which any
      right could or can be derived from the Patents, and cannot be prematurely
      terminated.

6.    During the term of the License, the Assignee shall not be entitled to use
      the Patents to develop, manufacture, have manufactured, market, sell,
      offer to sell and import bone tissue products in combination with calcium
      phosphate for application in orthopaedic procedures.

7.    The parties hereto agree to execute such formal documents as may be
      required for the purpose of registering the abovementioned licence in the
      relevant countries.

8.    The Assignee agrees, for the duration of the License, to sell under normal
      business conditions, and if available in the ordinary course of business,
      to the Assignor, at its request, calcium phosphate and calcium phosphate
      products, at prices no less favourable then the best price offered to
      comparable customers of the Purchaser for such quantities.

9.    The assignee agrees and warrants that it shall pay any and all applicable
      fees and that it shall do and omit all such other acts as may from time to
      time be necessary and/or appropriate to have the Patents issued and/or
      fully maintained for the designated territories as set forth in Annex I
      hereto (including but not limited to defending and prosecuting the
      Patents).

10.   Without any prejudice to clause 11, the License includes the right of the
      Assignor to -- at its own discretion -- defend and prosecute the Patents
      against claims of third parties and/or possible infringements by third
      parties, including but not limited to the right to initiate proceedings
      against such third parties in its own name and/or -- if the Assignor deems
      it necessary or desirable -- in the name of the Assignee.

11.   The Assignee shall procure and warrants that the License shall survive any
      assignment and/or encumberment of the Patents.

      Miscellaneous

12.   The Assignor shall render to the Assignee, at the Assignee's first
      request, any reasonable assistance which the Assignee deems necessary or
      desirable to defend or prosecute any of

                                                                           E-174
<PAGE>

                                                           Stibbe Draft 10/07/02

      the Patents, provided that any and all reasonable costs and expenses of
      the Assignor shall be reimbursed by the Assignee.

13.   Parties must inform each other immediately of any actions by third parties
      suspected of infringing the Patents, and in the event third parties claim
      infringement by the Patents.

14.   Each Party shall use and exploit the Patents for its own risk and account,
      and indemnifies and holds the other Party harmless against any and all
      claims, losses, damages, liabilities and expenses arising out of or
      relating to any claim of third parties in that respect.

15.   This Deed shall in all respects be exclusively governed by and deemed to
      have been construed in accordance with the laws of The Netherlands.

16.   Any dispute or claim arising out of or in connection with this Deed shall
      be referred to and exclusively and finally settled by the competent court
      in The Hague, The Netherlands.

This Deed has been signed in two original copies on 10 July 2002.

                                        ---------------------------------------
                                        CAM Acquisition B.V.

                                        on behalf of G.A. Kok Beheer B.V.

----------------------------------      by: Gerard Anton Kok
CAM IMPLANTS B.V.
                                        title: Director of G.A. Kok Beheer B.V.
by: Michael John Jeffries

title: Director

                                                                           E-175
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX I - Patents and Pending Patent Applications

<TABLE>
<CAPTION>
Atty Case#          Title                          Owner         Issued Patent #
------------------------------------------------------------------------------------
<S>                 <C>                            <C>           <C>
525400-153          Spherical Hydroxyapatite       Osteotech     5,702,677
                    Particles and Process for
                    the Production Thereof

525400-183          Spherical Hydroxyapatite       Osteotech     001032
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     69708870.7-08

PCT Germany         Particles and Process for
                    the Production Thereof

525400-175          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-181          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

525400-182          Spherical Hydroxyapatite       Osteotech     0910546
                    Particles and Process for
                    the Production Thereof

525400-185          Spherical Hydroxyapatite       Osteotech     0
                    Particles and Process for
                    the Production Thereof

285-144             Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

285-144 PCT         Calcium Phosphate Graft        Osteotech     0
                    Material, Process for Making
                    Same and Osteoimplant
                    Fabricated From Same

<CAPTION>
Atty Case#             Issue Date    Filing Date   Serial Number           Inventors           Country
----------------------------------------------------------------------------------------------------------
<S>                    <C>           <C>           <C>                     <C>                 <C>
525400-153             12/30/1997    7/10/1996     679,611                 Shimp, Renkema      U.S.

525400-183             8/28/2000     6/20/1997     199900055               Shimp, Renkema      Eurasia

525400-182             5/12/2001     6/20/1997     35175                   Shimp, Renkema      Germany

PCT Germany

525400-175                           6/20/1997     PCT/US97/16031          Shimp, Renkema      PCT

525400-181                           12/03/1998    2,257,290               Shimp, Renkema      Canada

525400-182             12/5/2001     6/20/1997     97941008.1              Shimp, Renkema      EPO

525400-185                           6/20/1997     PCT 710915/98           Shimp, Renkema      Korea

285-144                              12/15/2000    09/737,369              Shimp               U.S.

285-144 PCT                          12/15/2000    PCT/US00/33985          Shimp               PCT

</TABLE>

                                                                           E-176
<PAGE>

                                                           Stibbe Draft 10/07/02

                           DEED OF PLEDGE OF EQUIPMENT

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

NOW THEREFORE the parties hereto have agreed as follows:

1     Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement.

      "Goods" means all of the Pledgor's present and future machinery, equipment
      and inventory, including without limitations, fittings, furnishings,
      office equipment, automobiles and other rolling assets, as well as
      goods/movables forming part thereof or appurtenant thereto, all in the
      broadest sense of the word.

                                                                           E-177
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Default" has the meaning as defined in clause 7 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, all its Goods regardless of their condition and
      location, which pledge the Pledgee hereby accepts.

2.2   The Pledgee is entitled, at its discretion, to have this deed registered
      or to have the right of pledge recorded in a notarial deed. The Pledgor
      hereby grants irrevocable power of attorney to the Pledgee to have the
      pledge recorded in a notarial deed at any time, whether before or after
      registration of this deed, if the Pledgee so desires. For that purpose the
      Pledgee is authorised to execute such notarial deed on behalf of the
      Pledgor.

3.    Representations and Warranties

3.1   The Pledgor represents and warrants to the Pledgee that:

(i)   it has power ("beschikkingsbevoegdheid") to pledge the Goods;

(ii)  to the best of its knowledge, the Goods are not subject to any attachments
      ("beslag"), nor are any limited rights ("beperkte rechten") levied thereon
      or vested therein for the benefit of third parties, other than in
      accordance with clause 5.2 of the Agreement, nor are they subject to any
      right of retention ("retentierecht");

(iii) it has not previously and/or in advance transferred or created or promised
      to transfer or create, limited property rights on or against any of the
      Goods, or any part thereof, to or in favour of third parties, other than
      in accordance with clause 5.2 of the Agreement;

(iv)  the Goods are capable of being pledged in the manner set out herein.

4.    Ranking

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Covenants

5.1   The Pledgor undertakes to ensure that, upon its acquisition of the Goods,
      no limited rights are retained therein by the transferor. To the extent
      that its acquisition of any Goods is

                                                                           E-178
<PAGE>

                                                           Stibbe Draft 10/07/02

      subject to a retention of title, the Pledgor further undertakes to perform
      its obligations to the transferor in a timely and proper manner.

5.2   The Pledgor shall use the Goods in its Business only and in a manner
      consistent with their ordinary nature and purpose. The Pledgor will
      maintain the Goods in good repair and condition and do all that is
      necessary and/or deemed desirable by the Pledgee for this purpose. It
      shall neither take nor fail to take any action reasonably acquired in
      relation to the Goods, which could prejudice the interests of the Pledgee.
      If the Pledgor is in default of these obligations, the Pledgee shall be
      entitled to do whatever is reasonably necessary at the Pledgor's expense,
      without prejudice to its other rights.

5.3   The Pledgor undertakes to provide to the Pledgee, forthwith upon the
      latter's request to that effect at any time, a further specification of
      the Goods and/or the locations where they are situated. The failure to
      provide any such specification or the omission therefrom of any one or
      more of the Goods, shall not in any way detract from all Goods being
      pledged. The Pledgee and/or its appointees for this purpose shall be
      granted free access to the locations where the Goods are situated, in
      order to verify their presence and condition, during normal business
      hours. The refusal by a third party to grant such access shall be deemed a
      refusal by the Pledgor.

5.4   If at any time the Goods or any part thereof is held on its behalf by a
      third party, the Pledgor shall give immediate notice to such third party
      of the pledge of such Goods to the Pledgee. The Pledgor hereby grants
      irrevocable power of attorney to the Pledgee to do so itself, on its own
      and the Pledgor's behalf, if it so desires. To the extent any documents of
      storage or transportation are issued in respect of the Goods, such
      documents shall be immediately delivered and pledged to the Pledgee (in
      the case of endorsable commercial paper by way of endorsement).

5.5   The Pledgor shall, at its expense, have and hold the Goods insured on the
      usual conditions. It shall produce the policies of the relevant insurances
      to the Pledgee for review at the latter's first request. If the Pledgor is
      in default of this obligation, the Pledgee shall be entitled to arrange
      for insurance to its satisfaction at the Pledgor's expense. Upon the
      creation of a pledge as referred to in Article 3:229 of the Netherlands
      Civil Code ("NCC"), the Pledgee shall be entitled to give notice thereof
      to those held to indemnify.

5.6   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Goods, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

                                                                           E-179
<PAGE>

                                                           Stibbe Draft 10/07/02

5.7   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the Goods,
      failing which the Pledgee shall be entitled to give such notice.

6.    Alienation, Use

      Subject to clause 5.2 of the Agreement, the Pledgor may not alienate,
      encumber, lease or otherwise grant the use of the Goods to third parties
      without the prior written consent of the Pledgee, unless the price to be
      paid for such Goods by third parties does not exceed an aggregate amount
      of USD 15,000 quarterly. Upon the alienation of any Goods, the Pledgor
      shall replace such Goods in order to maintain the interests of the
      Pledgee.

7.    Possessory Pledge

      The Pledgee may require at any time when the Pledgor has not fulfilled or
      paid its Secured Obligations ("Event of Default"), all or a part of the
      Goods to be brought into its possession or that of a third party jointly
      appointed by it for this purpose.

8.    Enforcement

8.1   In case of an Event of Default, the Pledgee shall be entitled to sell the
      Goods and to recover the outstanding amount from the proceeds of sale.

8.2   In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties who have limited rights in or who have levied an
      attachment on any of the Goods, nor shall the Pledgee be obliged to give
      notice that a sale has occurred. The Pledgor hereby waives its right to
      apply to the President of the District Court for an order that the Goods
      be sold in a manner different from that provided for in Article 3:250 NCC
      and, if applicable, its rights under Article 3:234 NCC.

9.    Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Goods, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

10.   Release of Pledge

      The Pledgee shall only be held to release its pledge if, it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

11.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

                                                                           E-180
<PAGE>

                                                           Stibbe Draft 10/07/02

(i)   for perfecting, preserving or protecting the security created hereunder or
      the priority thereof; and

(ii)  for facilitating the collection, recovery and enforcement of the Goods or
      the exercise of any rights vested in the Pledgee.

12.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

13.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

14.   Power of Attorney

14.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Goods or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Goods or under or in connection with this
            deed.

14.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

15.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

16.   Amendments and Waivers

                                                                           E-181
<PAGE>

                                                           Stibbe Draft 10/07/02

16.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

16.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

17.   Governing Law and Jurisdiction

17.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

17.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

/s/ Michael John Jeffries               /s/ Gerard Anton Kok
--------------------------------        ----------------------------------------
CAM IMPLANTS B.V.                       CAM Acquisition B.V.

by: Michael John Jeffries               on behalf of G.A. Kok Beheer B.V.

title: Director                         by: Gerard Anton Kok

                                        title: Director of G.A. Kok Beheer B.V.

                                                                           E-182
<PAGE>

                                                           Stibbe Draft 10/07/02

                             DEED OF PLEDGE OF STOCK

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

NOW THEREFORE the parties hereto have agreed as follows:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Stock" means all of the Pledgor's present and future stock, including raw
      materials, ancillary materials and semi-finished products, as well as
      packaging material, all in the broadest sense of the word.

                                                                           E-183
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Defaulf" has the meaning as defined in clause 7 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, all its Stock regardless of their condition and
      location, which pledge the Pledgee hereby accepts.

2.2   The Pledgee is entitled, at its discretion, to have this deed registered
      or to have the right of pledge recorded in a notarial deed. The Pledgor
      hereby grants irrevocable power of attorney to the Pledgee to have the
      pledge recorded in a notarial deed at any time, whether before or after
      registration of this deed, if the Pledgee so desires. For that purpose the
      Pledgee is authorised to execute such notarial deed on behalf of the
      Pledgor.

3.    Representations and Warranties

3.1   The Pledgor represents and warrants to the Pledgee that:

(i)   it has power ("beschikkingsbevoegdheid") to pledge the Stock;

      (ii)  the Stock is not subject to any attachments ("beslag"), nor are any
            limited rights ("beperkte rechten") levied thereon or vested therein
            for the benefit of third parties, other than in accordance with
            clause 5.2 of the Agreement, or any right of retention
            ("retentierecht");

      (iii) it has not previously and/or in advance transferred or created or
            promised to transfer or create, limited property rights on or
            against any of the Stock, or any part thereof, to or in favour of
            third parties, other than in accordance with clause 5.2 of the
            Agreement;

      (iv)  the Stock is capable of being pledged in the manner set out herein.

4.    Ranking

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Covenants

                                                                           E-184
<PAGE>

                                                           Stibbe Draft 10/07/02

5.1   The Pledgor undertakes to ensure that, upon its acquisition of the Stock,
      no limited rights are retained therein by the transferor. To the extent
      that its acquisition of any Stock is subject to a retention of title, the
      Pledgor further undertakes to perform its obligations to the transferor in
      a timely and proper manner.

5.2   The Pledgor shall use the Stock in its Business only and in a manner
      consistent with their ordinary nature and purpose. The Pledgor will
      maintain the Stock in good repair and condition and do all that is
      necessary and/or deemed desirable by the Pledgee for this purpose. It
      shall neither take nor fail to take any action reasonably required in
      relation to the Stock, which could prejudice the interests of the Pledgee.
      If the Pledgor is in default of these obligations, the Pledgee shall be
      entitled to do whatever is reasonably necessary at the Pledgor's expense,
      without prejudice to its other rights.

5.3   The Pledgor undertakes to provide to the Pledgee, forthwith upon the
      latter's request to that effect at any time, a further specification of
      the Stock and/or the locations where they are situated. The failure to
      provide any such specification or the omission therefrom of any one or
      more of the Stock, shall not in any way detract from all Stock being
      pledged. The Pledgee and/or its appointees for this purpose shall be
      granted free access to the locations where the Stock are situated, in
      order to verify their presence and condition, during normal business
      hours. The refusal by a third party to grant such access shall be deemed a
      refusal by the Pledgor.

5.4   If at any time the Stock or any part thereof are held on its behalf by a
      third party, the Pledgor shall give immediate notice to such third party
      of the pledge of such Stock to the Pledgee. The Pledgor hereby grants
      irrevocable power of attorney to the Pledgee to do so itself, on its own
      and the Pledgor's behalf, if it so desires. To the extent any documents of
      storage or transportation are issued in respect of the Stock, such
      documents shall be immediately delivered and pledged to the Pledgee (in
      the case of endorsable commercial paper by way of endorsement).

5.5   The Pledgor shall, at its expense, have and hold the Stock insured on the
      usual conditions. It shall produce the policies of the relevant insurances
      to the Pledgee for review at the latter's first request. If the Pledgor is
      in default of this obligation, the Pledgee shall be entitled to arrange
      for insurance to its satisfaction at the Pledgor's expense. Upon the
      creation of a pledge as referred to in Article 3:229 of the Netherlands
      Civil Code ("NCC"), the Pledgee shall be entitled to give notice thereof
      to those held to indemnify.

5.6   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Stock, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

                                                                           E-185
<PAGE>

                                                           Stibbe Draft 10/07/02

5.7   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the Stock,
      failing which the Pledgee shall be entitled to give such notice.

6.    Alienation, Use

      Subject to clause 5.2 of the Agreement and other than in the ordinary
      course of business, the Pledgor may not alienate, encumber, lease or
      otherwise grant the use of the Stock to third parties without the prior
      written consent of the Pledgee. Upon the alienation of any Stock, the
      Pledgor shall replace such Stock in order to maintain the interests of the
      Pledgee.

7.    Possessory Pledge

      The Pledgee may require at any time when the Pledgor has not fulfilled or
      paid its Secured Obligations ("Event of Default"), all or a part of the
      Stock to be brought into its possession or that of a third party appointed
      by it for this purpose.

8.    Enforcement

8.1   In case of an Event of Default, the Pledgee shall be entitled to sell the
      Stock and to recover the outstanding amount from the proceeds of sale.

8.2   In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties who have limited rights in or who have levied an
      attachment on any of the Stock, nor shall the Pledgee be obliged to give
      notice that a sale has occurred. The Pledgor hereby waives its right to
      apply to the President of the District Court for an order that the Stock
      be sold in a manner different from that provided for in Article 3:250 NCC
      and, if applicable, its rights under Article 3:234 NCC.

9.    Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Stock, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

10.   Release of Pledge

      The Pledgee shall only be held to release its pledge if it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

11.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

                                                                           E-186
<PAGE>

                                                           Stibbe Draft 10/07/02

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Stock or the exercise of any rights vested in the Pledgee.

12.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

13.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

14.   Power of Attorney

14.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Stock or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Stock or under or in connection with this
            deed.

14.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

15.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

16.   Amendments and Waivers

                                                                           E-187
<PAGE>

                                                           Stibbe Draft 10/07/02

16.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

16.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

17.   Governing Law and Jurisdiction

17.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

17.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

                                         /s/ Gerard Anton Kok
                                         ---------------------------------------
                                         CAM Acquisition B.V.

                                         on behalf of G.A. Kok Beheer B.V.
/s/ Michael John Jeffries
--------------------------------         by: Gerard Anton Kok
CAM IMPLANTS B.V.
                                         title: Director of G.A. Kok Beheer B.V.
by: Michael John Jeffries

title: Director

                                                                           E-188
<PAGE>

                                                           Stibbe Draft 10/07/02

                          DEED OF PLEDGE OF RECEIVABLES

This deed is entered into on the 10th day of July 2002

BETWEEN

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

NOW THEREFORE the parties hereto agree as follows:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Receivables" means all receivables ("vorderingen op naam") of the Pledgor
      on third parties, whether for goods delivered, services performed or for
      any other reason whatsoever;

                                                                           E-189
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Event of Default" has the meaning as defined in clause 8 of this deed of
      pledge.

2.    Pledge

2.1   As security for the fulfilment of the Secured Obligations and subject to
      clause 5.2 of the Agreement, the Pledgor hereby pledges to the Pledgee,
      whether or not in advance, which pledge the Pledgee hereby accepts, the
      Receivables, insofar as these are capable of being pledged on the date of
      signing this deed, and undertakes to pledge to the Pledgee the Receivables
      which become capable of being pledged after the date of signing this deed
      as soon as such Receivables shall be capable of being so pledged.

2.2   For the first time upon the signing of this deed, and thereafter as soon
      as any Receivables are capable of being pledged at three monthly
      intervals, the Pledgor shall deliver to the Pledgee pledge lists in the
      form of Annex A hereto, duly signed and completed, and identifying all
      Receivables which are then capable of being pledged. By accepting delivery
      of any pledge list, the Pledgee accepts the pledge to it of the
      Receivables identified thereon. The Pledgee may, at its discretion,
      register or have registered this deed together with the pledge lists, or
      have such deed and lists recorded in a notarial deed. In the latter event,
      the Pledgee is authorised to execute the notarial deed on behalf of the
      Pledgor.

2.3   The first pledge list shall be attached to this deed, and the Pledgor
      shall thereafter deliver pledge lists to the Pledgee at its first request
      at least once every three months (i.e. end of February, end of May, end of
      August and end of November) or as often as the Pledgee shall reasonably
      require. A more frequent delivery of pledge lists shall be deemed to occur
      at the Pledgee's request.

3.    Representations and Warranties

      The Pledgor represents and warrants to the Pledgee that:

      (i)   it has power ("beschikkingsbevoegdheid") to pledge the Receivables;

      (ii)  the Receivables are duly and validly existing;

      (iii) the Receivables are not subject to any attachments ("beslag"), nor
            are there any limited rights ("beperkte rechten") levied thereon or
            vested therein for the benefit of third parties, other than in
            accordance with clause 5.2 of the Agreements;

      (iv)  it has not previously and/or in advance transferred or created or
            promised to transfer or create, limited property rights on or
            against any of the Receivables, or any part thereof, to or in favour
            of third parties, other than in accordance with clause 5.2 of the
            Agreements;

      (v)   the Receivables are capable of being pledged in the manner set out
            herein.

4.    Ranking

                                                                           E-190
<PAGE>

                                                           Stibbe Draft 10/07/02

      Subject to clause 5.2 of the Agreement the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge.

5.    Ancillary Rights

      The Receivables are pledged together with all rights, including dependent
      and ancillary rights, privileges and rights of actions attached thereto.
      Insofar as necessary, the Pledgor hereby irrevocably authorises the
      Pledgee to exercise these rights on its behalf. The Pledgee is released
      from the formality of protesting endorsable commercial paper.

6.    Covenants

6.1   The Pledgor shall at all times supply and provide to the Pledgee at its
      first request all evidence and documents relating to the Receivables and
      all information and assistance which the Pledgee may deem reasonably
      necessary for the exercise of its rights pursuant hereto.

6.2   The Pledgor shall, if so requested, allow the Pledgee regular examination
      of its debtor administration and all documents related thereto.

6.3   Insofar as the pledge relates to Receivables from non-Dutch debtors or
      governed by foreign law, the Pledgor further undertakes to perform all
      such acts and render all such assistance as the Pledgee may deem
      reasonably necessary based on applicable rules and regulations.

6.4   The Pledgor shall notify the Pledgee immediately of all circumstances,
      which could affect the Pledgee's interests. Such circumstances shall
      include, without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes or social security premiums or planning to notify the relevant
      authorities thereof, an attachment being levied on some or all of the
      Receivables, or an event analogous to any of the above occurring under the
      laws of any other jurisdiction.

6.5   The Pledgor shall also give immediate notice of the Pledgee's right of
      pledge to anyone seeking to assert any right in respect of the
      Receivables, failing which the Pledgee shall be entitled to give such
      notice.

7.    Assignment

                                                                           E-191
<PAGE>

                                                           Stibbe Draft 10/07/02

      Subject to clause 5.2 of the Agreement, the Pledgor may not assign,
      encumber or otherwise alienate or transfer any rights in relation to the
      Receivables to third parties without the prior written consent of the
      Pledgee.

8.    Notification of Pledge

      In case the Pledgor has not fulfilled its Secured Obligations ("Event of
      Default") the Pledgee shall be entitled at all times to give notice of the
      pledge to the debtors of the Receivables.

9.    Authority to Collect

9.1   After having given notice of the pledge, the Pledgee shall be entitled to
      collect the Receivables by judicial or extrajudicial proceedings, to grant
      discharge in respect thereof, to enter into compromises, settlements and
      other agreements with the debtors of the Receivables, and to exercise all
      other rights of the Pledgor in this respect.

9.2   The Pledgee shall not, on any account whatsoever, be liable to the Pledgor
      or its successors in title for any failure to collect or to collect in
      full any of the Receivables.

9.3   All costs incurred in the collection of the Receivables shall be for the
      account of the Pledgor, even if the Pledgee for whatever reason fails to
      collect any of the Receivables or fails to do so in full.

10.   Enforcement

10.1  In case of an Event of Default, the Pledgee shall, in addition to its
      rights pursuant to clauses 8 and 9 above, be entitled to sell the
      Receivables and to recover the outstanding amount from the proceeds of
      collection pursuant to clause 9 above and/or the proceeds of sale.

10.2  In case of an Event of Default, the Pledgee shall not be obliged, when
      intending to proceed to sale, to give notice thereof to the Pledgor or to
      any third parties having limited rights in or levied attachment on any of
      the Receivables, nor shall the Pledgee be obliged to give notice of any
      sale subsequent thereto. The Pledgor hereby waives its right to apply to
      the President of the District Court for an order that the Receivables be
      sold in a manner different from that provided for in Article 3:250 of the
      Netherlands Civil Code ("NCC") and, if applicable, its rights under
      Article 3:234 of the NCC.

11.   Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Receivables, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

12.   Release of Pledge

                                                                           E-192
<PAGE>

                                                           Stibbe Draft 10/07/02

      The Pledgee shall only be held to release its pledge if, it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

13.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Receivables or the exercise of any rights vested in the Pledgee.

14.   Costs

      All cost related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extrajudicial exercise by the Pledgee of its rights hereunder (i.e.
      foreclosure), including legal fees and costs of litigation, shall be borne
      by the Pledgor.

15.   No Nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

16.   Power of Attorney

16.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the
            Receivables or any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Receivables or under or in connection
            with this deed.

16.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 16.1 hereof.

17.   Severability

                                                                           E-193
<PAGE>

                                                           Stibbe Draft 10/07/02

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

18.   Amendments and Waivers

18.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

18.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

19.   Governing Law and Jurisdiction

19.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

19.2  All disputes arising out of this deed shall be submitted to the competent
      court in Amsterdam, the Netherlands. Nothing in the preceding sentence
      shall limit the Pledgee's right to bring proceedings against the Pledgor
      in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

                                         /s/ Gerard Anton Kok
                                         ---------------------------------------
                                         CAM Acquisition B.V.

                                         on behalf of G.A. Kok Beheer B.V.
/s/ Michael John Jeffries
--------------------------------         by: Gerard Anton Kok
CAM IMPLANTS B.V.
                                         title: Director of G.A. Kok Beheer B.V.
by: Michael John Jeffries

title: Director

                                                                           E-194
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX A

To: CAM IMPLANTS B.V.

                                   PLEDGE LIST

The undersigned, CAM AQCUISITION B.V., established in Zernikedreef 6, 2333 CL
Leiden, the Netherlands, pledges pursuant to the deed of pledge of receivables
dated 10 July 2002 between the undersigned and the addressee (the "Deed of
Pledge of Receivables") to you all Receivables set out in the list attached as
Schedule I to this pledge list to you. The details of this list are set out
below.

date: 9 July 2002
number of pages: 2
first debtor's name: ***
amount first Receivable: ***
date first contract/number of invoice: unknown
last debtor's name: ***
amount last Receivable: ***
date last contract/number of invoice: unknown
total Receivables: ***
outstanding as per: before 9 July 2002

Capitalized terms used in this pledge list have, unless expressly defined
otherwise herein, the same meaning as in the Deed of the Pledge of Receivables.

The undersigned hereby represents and warrants that the matters set out in
Clause 3 of the Deed of Pledge of Receivables are true and correct as at the
date hereof with regard to the Receivables pledged hereby.

Copies of invoices, contracts, and/or other relevant documentation such as
delivery receipts associated with these receivables are held at your disposal.

/s/ Gerard Anton Kok
----------------------------------------
CAM Acquisition B.V.

on behalf of G.A. Kok Beheer B.V.

by: Gerard Anton Kok

title: Director of G.A. Kok Beheer B.V.

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-195
<PAGE>

                               45: CAM Implants BV
                          Aged Debt Report by Due Date
                          Division: 45 CAM Implants BV.
                      in Base Currency: EUR: Euro Currency

<TABLE>
<CAPTION>
                      Total         1-Jun-2002 to        1-May to       1-Apr to        1-Mar to          Before           In
                   Outstanding        9-JUL-2002       31-May 2002    30-Apr 2002      31-Mar 20        28-Feb 2002      Dispute
                   -----------        ----------       -----------    -----------      ---------        -----------      -------
<S>                <C>               <C>                        <C>            <C>            <C>               <C>              <C>
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***
***                ***
                   ***                                          ***            ***            ***               ***              ***

TOTAL for
Currency: EUR      ***                                          ***            ***            ***               ***              ***
</TABLE>

----------
***Indicates the omission of confidential material pursuant to a request for
confidential treatment made in accordance with Rule 24b-2 under the Securities
Exchange Act of 1934, as amended. The confidential material is being filed
separately with the Secretary to the Securities and Exchange Commission.

                                                                           E-196
<PAGE>

                                                           Stibbe Draft 10/07/02

                 DEED OF PLEDGE OF INTELLECTUAL PROPERTY RIGHTS

This deed is entered into on the 10th day of July 2002

BETWEEN:

1.    CAM ACQUISITION B.V., a company with limited liability (besloten
      vennootschap met beperkte aansprakelijkheid), incorporated under the laws
      of the Netherlands, with its registered and principal office at
      Zernikedreef 6, 2333 CL Leiden, the Netherlands, validly represented by
      Gerard Anton Kok on behalf of G.A. Kok Beheer B.V. (the "Pledgor");

and

2.    CAM IMPLANTS B.V., a company with limited liability (besloten vennootschap
      met beperkte aansprakelijkheid), incorporated under the laws of the
      Netherlands, with its registered office at Zernikedreef 6, 2333 CL,
      Leiden, the Netherlands, validly represented by Michael John Jeffries (the
      "Pledgee").

WHEREAS:

(A)   on 10 July 2002 the Pledgor and the Pledgee have entered into an asset
      purchase agreement (the "Agreement") in order to sell, purchase and
      transfer certain of the assets and certain of the liabilities from the
      Pledgee to the Pledgor;

(B)   pursuant to the terms of the Agreement, the Pledgor is required to grant
      valid, perfected and enforceable liens on all of its assets, including
      without limitation all of its inventory, accounts receivable, general
      intangibles, machinery, equipment and intellectual property for the
      benefit of the Pledgee;

HAVE AGREED AS FOLLOWS:

1.    Interpretation and Definitions

1.1   Except where the context otherwise requires or when otherwise defined
      herein, words and expression defined in the Agreement have the same
      meanings when used in this deed of pledge (including its recitals).

1.2   Furthermore, in this deed of pledge (including its recitals) the following
      expressions shall have the following meaning:

      "Existing IP Rights" means the Copyrights, Database Rights, Designs,
      Licensee Rights, Internet Domain Names, Patents, Trade Marks and/or Trade
      Secrets, along with any and all income, royalties, damages and payments at
      any time due or payable to Pledgor with respect thereto, including without
      limitation damages and payments for past or future infringements or
      misappropriations thereof, in any state or country, and all including,
      without limitation, the (pending) trademarks attached hereto as Annex A,
      all rights with respect to the patents and patent applications listed in
      Annex B, the internet domain name

                                                                           E-197
<PAGE>

                                                           Stibbe Draft 10/07/02

      as set out attached hereto as Annex C, or otherwise existing at the time
      of execution of this Agreement;

      "Future IP Rights" means any and all Copyrights, Database Rights, Designs,
      Licensee Rights, Internet Domain Names, Patents, Trade Marks and/or Trade
      Secrets, along with any and all income, royalties, damages and payments at
      any time due or payable to Pledgor with respect thereto, including without
      limitation damages and payments for past or future infringements or
      misappropriations thereof, in any state or country, applied for, granted
      to, acquired or owned by Pledgor subsequent to the execution of this
      Agreement;

      "Copyrights" means any and all copyrights, whether registered or not,
      within the meaning of (i) the Dutch Copyright Act (Auteurswet), (ii) the
      Convention of Bern, (iii) the Universal Copyright Convention, or (iv) any
      similar, present or future, legal regime, and including any pending
      applications for such rights (to the extent relevant under Applicable
      Law), in The Netherlands and/or in any other state or country, owned by
      Pledgor;

      "Database Rights" means any and all rights, whether registered or not, in
      databases within the meaning of (i) the Dutch Database Act
      (Databankenwet), (ii) the Directive 96/9/EC of the European Parliament and
      of the Council of 11 March 1996 on the legal protection of databases or
      (iii) any similar, present or future, legal regime, and including any
      pending applications for such rights (to the extent relevant under
      Applicable Law), in The Netherlands and/or in any other state or country,
      owned by Pledgor;

      "Designs" means any and all rights, whether registered or not, in designs
      within the meaning of (i) the Uniform Benelux Designs Act (Eenvormige
      Beneluxwet inzake Tekeningen of Modellen), (ii) the Directive 98/71/EC of
      the European Parliament and of the Council of 13 October 1998 on the legal
      protection of designs or (iii) any similar, present or future, legal
      regime, and including any pending applications for such rights (to the
      extent relevant under Applicable Law), in The Netherlands, the Benelux
      and/or any other state or country, owned by Pledgor;

      "Internet Domain Names" means any and all rights, whether registered or
      not, in internet domain names, and including any pending applications for
      such rights (to the extent relevant under Applicable Law), in the name of
      Pledgor, in The Netherlands and/or in any other state or country;

      "Licensee Rights" means any and all rights of Pledgor, whether registered
      or not, pursuant to any licence agreements, whether written or oral, with
      third parties by which Pledgor has obtained rights (of whatever nature) to
      use, copy, distribute, market, sub-license, sell or otherwise exploit or
      apply any and all Copyrights, Database Rights, Designs, Patents, Trade
      Marks and/or Trade Secrets, in The Netherlands and/or in any other state
      or country, as well as any rights or permits of Pledgor in connection with
      any Internet Domain Names, all to the extent that such licence agreements
      do not prohibit Pledgor to grant a right of pledge on their respective
      rights thereunder;

                                                                           E-198
<PAGE>

                                                           Stibbe Draft 10/07/02

      "Patents" means any and all rights, whether registered or not, in patents
      within the meaning of (i) the Dutch Patent Acts of 1910 or 1995,
      respectively, (Rijksotrooiwet 1910 of Rijksoctrooiwet 1995), (ii) the
      European Patent Convention of 1973, (iii) the Patent Cooperation Treaty of
      1970 or (iv) any similar, present or future, legal regime, whether
      registered or not, and including any pending applications for such rights
      (to the extent relevant under Applicable Law), in The Netherlands and/or
      in any other state or country, owned by the Pledgor;

      "Trade Marks" means any and all rights, whether registered or not, in
      trade marks and trade names and all goodwill associated therewith, within
      the meaning of (i) the Benelux Trade Mark Act (Benelux Merkenwet), (ii)
      the Dutch Trade Names Act (Handelsnaamwet), (iii) EU Council Regulation
      (EC) No 40/94 on the Community trade mark or (iv) any similar, present or
      future, legal regime, whether registered or not, and including any pending
      applications for such rights (to the extent relevant under Applicable
      Law), in The Netherlands and/or in any other state or country, owned by
      Pledgor;

      "Trade Secrets" means any and all rights, whether registered or not, in
      trade secrets and all non-public information or confidential information,
      (including, without limitation, inventions, discoveries, improvements,
      customer lists, know-how and ideas) whether registered or not, and
      including any pending applications for such rights (to the extent relevant
      under Applicable Law), in The Netherlands and/or in any other state or
      country, owned by Pledgor;

      "Pledge Confirmation" has the meaning as defined in clause 2.2 of this
      deed of pledge;

      "Rights" means collectively the Existing IP Rights and the Future IP
      Rights;

      "Secured Obligations" means the Pledgor's payment obligations pursuant to
      clause 3.1 through clause 3.4 of the Agreement;

      "Event of Default" has the meaning as defined in clause 2.3 of this deed
      of pledge.

2.    Pledge

2.1   As additional security for the fulfilment of the Secured Obligations and
      subject to clause 5.2 of the Agreement, the Pledgor hereby pledges
      ("verpandt") to the Pledgee, whether or not in advance, all the Rights,
      which pledge the Pledgee hereby accepts.

2.2   Immediately after the Pledgor will have acquired Future IP Rights he will
      notify the Pledgee thereof in writing, specifying the details of such
      Future IP Rights. The Pledgor will then also execute a notice of
      confirmation substantially in the form of Annex D hereto (the "Pledge
      Confirmation") to confirm that such Future IP Rights are thereby pledged
      to the Pledgee on the terms and conditions set out in this deed of pledge.
      The Pledgee will accept the pledge of the Future IP Rights specified in
      the Pledge Confirmation by signing the Pledge Confirmation for acceptance
      and returning it to the Pledgor. The Pledgor shall upon receipt of the
      signed Pledge Confirmation from the Pledgee submit it to the relevant
      authorities to obtain registration of the pledge.

                                                                           E-199
<PAGE>

                                                           Stibbe Draft 10/07/02

2.3   The Rights are pledged to the Pledgee with all privileges connected
      therewith and all other rights ancillary thereto ("afhankelijke en
      nevenrechten"). Insofar necessary the Pledgor hereby irrevocably
      authorises and gives power of attorney to the Pledgee to exercise such
      rights on behalf of the Pledgor following the occurrence and during the
      continuation of a situation that the Pledgor has not fulfilled or paid its
      Secured Obligations ("Event of Default").

3.    Registration

3.1   The creation of the rights of pledge on the Rights created hereby or to be
      created under or pursuant to this deed of pledge in accordance with clause
      2.2 above is effected by the fact that the parties hereto sign this deed.

3.2   The rights of pledge on the IP Rights and the Future IP Rights created
      hereunder will have effect against third parties by the subsequent
      registration of this deed of pledge and the relevant Pledge Confirmations
      at the relevant national and international authorities.

3.3   The Pledgor hereby irrevocably appoints the Pledgee and any person
      nominated by the Pledgee in its name and on its behalf and expense to
      register, record or file this deed of pledge and Pledge Confirmations with
      the relevant authorities and any further registers or offices where the
      right of pledge created hereby, in the reasonable opinion of the Pledgee,
      requires to be registered, recorded or filed.

3.4   For purposes of Article 40(2) of the Netherlands Patent Act 1910 and of
      Article 67(2) of The Netherlands Patent Act 1995 the Pledgee hereby
      chooses domicile at the Bureau lndustriele Eigendom, The Hague, the
      Netherlands, or at such office as may be designated in the future in the
      Netherlands Patent Act for similar purposes.

4.    Protection of Rights

4.1   Without prejudice to the Pledgor's obligations under this deed of pledge,
      the Pledgor hereby authorises the Pledgee (such authorisation not meaning
      that the Pledgee is obliged to take any of the following actions), and for
      the purposes thereof the Pledgor hereby gives, on the condition precedent
      of the occurrence of an Event of Default, full power of attorney to the
      Pledgee and any person nominated by the Pledgee, to take in the Pledgor's
      name and on the Pledgor's behalf and expense, all actions deemed necessary
      by the Pledgee to fully protect or perfect the rights of pledge granted
      hereunder and to take in the Pledgor's name and on the Pledgor's behalf
      and expense, all actions deemed necessary by the Pledgee to fully protect
      the Rights and to fully protect or perfect the rights of pledge granted
      hereunder, including but not limited to timely renewing the Rights in the
      registers, paying the fees of registration and instituting legal
      proceedings and the signing, at any time, on its behalf of Pledge
      Confirmations substantially in the form of Annex D hereto. The Pledgor
      shall promptly notify the Pledgee in writing of any issues that arise with
      regard to the protection of the Rights and provide any assistance the
      Pledgee reasonably requests. In connection with the power of attorney
      contained in this clause the Pledgor waives his rights pursuant to Article
      3:68 of the Netherlands Civil Code ("NCC"), which waiver the Pledgee
      hereby accepts.

                                                                           E-200
<PAGE>

                                                           Stibbe Draft 10/07/02

4.2.  The Pledgor hereby covenants at the Pledgee's first request (i) to execute
      such other instruments, deeds, forms or agreements, choice of domicile,
      (ii) make or cause to be made such further recordings, registrations or
      filings, or (iii) take or cause to be taken such further action as the
      Pledgee will deem necessary or advisable to (further) perfect or protect
      the rights of pledge of the Rights created hereby in all countries where
      the Rights are registered or effective from time to time.

4.3   The Pledgor shall retain possession of evidence of the normal, adequate
      and proper use that was made or is being made of the trademarks listed in
      Annex A. This evidence includes, but is not limited to, samples of
      products, packaging, promotional material and copies of some invoices to
      customers, containing the registered trademark. The Pledgor shall forward
      this evidence of use to the Pledgee upon the Pledgee's first request.

5.    Representations and Warranties

5.1   The Pledgor hereby represents, warrants and declares to the Pledgee that:

      (i)   to the best of its knowledge, it is the exclusive proprietor of, and
            has power ("beschikkingsbevoegdheid") to pledge, the Rights and that
            there are no attachments ("beslagen") and there are not and will not
            be any security interests or limited rights ("beperkte rechten")
            levied thereon or vested therein for the benefit of third parties
            other than in accordance with clause 5.2 of the Agreement, nor any
            right of retention ("retentierecht") on or against the Rights;

      (ii)  it makes and will make normal use of the trademarks listed in Annex
            A and will continue to use all trademarks in conformity with the
            registration thereof;

      (iii) it has not previously and/or in advance transferred or created
            limited rights ("beperkte rechten") in or against the Rights either
            in whole or in part, to or in favour of third parties other than in
            accordance with clause 5.2 of the Agreement;

      (iv)  to the best of its knowiedge, this deed of pledge constitutes the
            legal, valid and binding obligations of the Pledgor; and

      (v)   it has full power, authority and legal right to execute, deliver and
            perform his obligations under this deed of pledge and to pledge the
            Rights pursuant to this deed of pledge, and the execution, delivery
            and performance hereof and the pledge of and grant of a security
            interest in the Rights hereunder have been duly authorised by all
            necessary corporate or other action and do not contravene any law,
            rule or regulation or any provision of the Pledgor's charter
            documents or by-laws or of any judgment, decree or order of any
            tribunal or of any agreement or instrument to which the Pledgor is a
            party or by which it or any of its property is bound or affected or
            constitute a default thereunder.

5.2   The representations and warranties in clause 5.1 above shall be deemed to
      be repeated by the Pledgor on each of the dates on which a Pledge
      Confirmation is executed by the Pledgor, as if made with reference to the
      facts and circumstances then existing and with reference to the Rights
      contained in all Pledge Confirmations.

                                                                           E-201
<PAGE>

                                                           Stibbe Draft 10/07/02

6.    Ranking

      Subject to clause 5.2 of the Agreement, the right of pledge as granted to
      the Pledgee pursuant to this deed of pledge will in general be first in
      ranking against any other security interests that may be granted by the
      Pledgor to any third party. In the event the Pledgor desires to grant any
      security interests to its bank in order to finance the ongoing Business,
      after the Assets and Liabilities have been transferred in accordance with
      the Agreement, the Pledgee undertakes to provide to the Pledgor's bank,
      forthwith upon the latter's request to that effect at any time, a
      statement that such security interests will prevail in ranking against the
      right of pledge as granted by the Pledgor pursuant to this deed of pledge

7.    Covenants

7.1   Subject to clause 3.6 of the Agreement, the The Pledgor has submitted or
      shall submit respectively declares to have submitted all necessary
      documents to the relevant registers to achieve proper and valid
      registration of the Rights in his name.

7.2   The Pledgor undertakes to timely renew the registrations of the Rights in
      order to prevent the lapsing or expiration of these rights and the
      registration thereof at the relevant authorities.

7.3   The Pledgor shall notify the Pledgee immediately of all circumstances that
      could affect the Pledgee's interests. Such circumstances shall include,
      without limitation, an application being filed for the Pledgor's
      bankruptcy ("faillissement"), the Pledgor being adjudicated bankrupt
      ("failliet wordt verklaard"), the Pledgor being granted (provisional)
      suspension of payments ("(voorlopige) surseance van betaling wordt
      verleend"), the Pledgor being unable to fully pay its debts in respect of
      taxes and social security premiums or planning to notify to the relevant
      authorities thereof, an attachment being levied on some or all of the
      Rights, or an event analogous to any of the above occurring under the laws
      of any other jurisdiction.

7.4   The Pledgor declares that, after the occurrence and during the
      continuation of an Event of Default, in all actual or legal disputes,
      concerning the Rights, it will act in accordance with instructions to be
      given by the Pledgee.

7.5   The Pledgor shall defend the rights and security interests of the Pledgee
      in the Rights against any claims and demands of any third parties.

8.    Alienation, Use

8.1   Subject to clause 5.2 of the Agreement, the Pledgor may not alienate,
      encumber, license or otherwise grant the use of the Rights to third
      parties without the prior written consent of the Pledgee.

9.    Enforcement

                                                                           E-202
<PAGE>

                                                           Stibbe Draft 10/07/02

9.1   Without prejudice to the rights and remedies provided to the Pledgee by
      law and subject to the mandatory rules of law, the Pledgee shall be
      entitled, in case of an Event of Default, to take all measures, whether
      judicial or extra-judicial, which a Pledgee may take in the event of
      execution of the pledged rights and which are permitted by law and which
      in his opinion are required in his interests, including without
      limitation, the sale of the Rights and the recovery of the outstanding
      amount from the proceeds of the sale.

9.2   In case of an Event of Default, the Pledgee shall be under no obligation
      to inform the Pledgor, or any third party having limited rights ("beperkte
      rechten") in or levied attachment on or against all or any part of the
      Rights, of its intention to collect or foreclose thereon. The Pledgor
      hereby waives its right to apply to the President of the District Court
      for an order that the Rights be sold in a manner different from that
      provided for in Article 3:250 NCC, and, if applicable, its rights under
      Article 3:234 NCC, which waiver is hereby accepted by the Pledgee.

9.3   The Pledgee shall not be liable to the Pledgor or its successors in
      interest for any damages caused by the sale of the Rights, gross
      negligence and wilful misconduct excepted.

10.   Application of Proceeds

      In case of an Event of Default, the Pledgee shall apply the proceeds from
      the sale of the Rights, after deduction of all costs, towards the
      settlement of the amounts owed by the Pledgor pursuant to the Secured
      Obligations in accordance with the provisions of the Agreement and this
      deed of pledge.

11.   Release of Pledge

      The Pledgee shall only be held to release its pledge if it has no further
      claims against the Pledgor pursuant to the Secured Obligations.

12.   Further Assurances

      The Pledgor shall, at its own cost, promptly execute all such assurances
      and documents and do all such acts and things in such form as the Pledgee
      may from time to time reasonably require:

      (i)   for perfecting, preserving or protecting the security created
            hereunder or the priority thereof; and

      (ii)  for facilitating the collection, recovery and enforcement of the
            Rights or the exercise of any rights vested in the Pledgee.

13.   Costs

      All costs related to the drafting of this deed shall be borne by the
      Pledgee. All reasonable costs, of whatever nature, related to the judicial
      and/or extra-judicial exercise by the Pledgee of its rights hereunder
      (i.e. foreclosure), including legal fees and costs of litigation, shall be
      borne by the Pledgor.

                                                                           E-203
<PAGE>

                                                           Stibbe Draft 10/07/02

14.   No nullification/dissolution

      The Pledgor and the Pledgee explicitly waive all their rights to rescind
      (ontbinden) or avoid (vernietigen) this deed, except for their right to
      invoke section 44 of book 3 BW (in the highly unlikely event that this
      would be necessary). The Pledgor and the Pledgee also explicitly waive
      their right to invoke section 258 of book 6 BW.

15.   Power of Attorney

15.1  The Pledgor hereby appoints, on the condition precedent of the occurrence
      of an Event of Default, irrevocably and by way of security, the Pledgee to
      be its attorney (with full powers of substitution and delegation), on its
      behalf and in its name, at such time and in such manner as the attorney
      may think fit:

      (i)   to do anything which the Pledgor is obliged to do (but has not done)
            under this deed including, but without limitation, to complete and
            execute any document to perfect any right of pledge on the Rights or
            any part thereof; and

      (ii)  generally to exercise all or any of the rights conferred on the
            Pledgee in relation to the Rights or under or in connection with
            this deed.

15.2  The Pledgor covenants to ratify and confirm whatever any attorney shall do
      or purport to do in the exercise or purported exercise of the power of
      attorney in clause 15.1 hereof.

16.   Severability

      In the event a provision hereof were to be ruled at any time by any
      applicable authority or court to be invalid or null and void or
      unenforceable, such invalidity or nullity or unenforceability shall not
      affect the validity or enforceability of the other provisions hereof and
      the parties hereto shall agree on a new provision consistent with the
      purposes of the invalid or unenforceable provision of this deed of pledge.

17.   Amendments and Waivers

17.1  No variation, amendment, release, waiver or modification of the terms and
      conditions of this deed of pledge shall be effective unless made in
      writing and signed by the Pledgee and the Pledgor.

17.2  No failure or delay by the Pledgee in exercising any right, power or
      remedy under this deed of pledge shall operate as a waiver thereof or
      shall impair such right, power or remedy, nor shall any single or partial
      exercise of any right, power or remedy preclude any further exercise
      thereof or the exercise of any other right, power or remedy.

18.   Governing Law and Jurisdiction

18.1  This deed shall be governed by and construed in accordance with the laws
      of the Netherlands.

                                                                           E-204
<PAGE>

                                                           Stibbe Draft 10/07/02

18.2  All disputes arising out of this deed of pledge shall be submitted to the
      competent court in Amsterdam, the Netherlands. Nothing in the preceding
      sentence shall limit the Pledgee's right to bring proceedings against the
      Pledgor in any other court of competent jurisdiction.

IN WITNESS WHEREOF the parties hereto have signed this deed of pledge in two
original copies on 10 July 2002 in Amsterdam.

/s/ Michael John Jeffries                /s/ Gerard Anton Kok
--------------------------------         ---------------------------------------
CAM IMPLANTS B.V.                        CAM Acquisition B.V.

by: Michael John Jeffries                on behalf of G.A. Kok Beheer B.V.

title: Director                          by: Gerard Anton Kok

                                         title: Director of G.A. Kok Beheer B.V.

                                                                           E-205
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX A - Trademarks and Trademark Applications

1.    The product names, including all their registrations and pending
      applications, "CAMCERAM" and "TAM".

2.    The company name "CAM Implants B.V.", including its registration
      certificate at the "Benelux Merkenbureau" (CAM document nr. 23).

                                                                           E-206
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX I - Patents and Pending Patent Applications

<TABLE>
<CAPTION>
Atty Case#          Title                          Owner         Issued Patent #
----------------------------------------------------------------------------------------
<S>                 <C>                            <C>           <C>
525400-153          Spherical Hydroxyapatite       CAM           5,702,677
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-183          Spherical Hydroxyapatite       CAM           001032
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-182          Spherical Hydroxyapatite       CAM           69708870.7-08

PCT Germany         Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-175          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-181          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-182          Spherical Hydroxyapatite       CAM           0910546
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

525400-185          Spherical Hydroxyapatite       CAM           0
                    Particles and Process for      Acquisition
                    the Production Thereof         B.V.

285-144             Calcium Phosphate Graft        CAM           0
                    Material, Process for Making   Acquisition
                    Same and Osteoimplant          B.V.
                    Fabricated From Same

285-144 PCT         Calcium Phosphate Graft        CAM           0
                    Material, Process for Making   Acquisition
                    Same and Osteoimplant          B.V.
                    Fabricated From Same

<CAPTION>
Atty Case#            Issue Date    Filing Date   Serial Number           Inventors           Country
-------------------------------------------------------------------------------------------------------------
<S>                   <C>           <C>           <C>                     <C>                 <C>
525400-153            12/30/1997    7/10/1996     679,611                 Shimp, Renkema      U.S.

525400-183            8/28/2000     6/20/1997     199900055               Shimp, Renkema      Eurasia

525400-182            5/12/2001     6/20/1997     35175                   Shimp, Renkema      Germany

PCT Germany

525400-175                          6/20/1997     PCT/US97/16031          Shimp, Renkema      PCT

525400-181                          12/03/1998    2,257,290               Shimp, Renkema      Canada

525400-182            12/5/2001     6/20/1997     97941008.1              Shimp, Renkema      EPO

525400-185                          6/20/1997     PCT 710915/98           Shimp, Renkema      Korea

285-144                             12/15/2000    09/737,369              Shimp               U.S.

285-144 PCT                         12/15/2000    PCT/US00/33985          Shimp               PCT

</TABLE>

                                                                           E-207
<PAGE>

                                                           Stibbe Draft 10/07/02

ANNEX C - Internet Domain Names

The registration of the existing internet domain www.camimplants.nl and all
rights and obligations adhering to it.

                                                                           E-208
<PAGE>

ANNEX D -- Pledge Confirmation

[Patent or Trade Mark Register] [Address]
[Place]
[Date]

Dear Sirs,

Pledge of IP rights

We hereby inform you that pursuant to the deed of pledge of IP Rights dated 9
July 2002 (the "Deed of Pledge") a first-ranking right of pledge on all of its
present and future intellectual property rights was created by CAM Acquisition
B.V. in favour of CAM IMPLANTS B.V. (hereinafter referred to as the Pledgee), a
corporation incorporated and existing under the laws of the Netherlands, with
corporate seat and having its registered office at Zernikedreef 6, 2333 CL,
Leiden, the Netherlands, the Netherlands.

This is to confirm that on [date] CAM Acquisition B.V. has acquired IP Rights,
particulars of which are set forth in the annex to this letter. CAM Acquisition
B.V., in order to secure the prompt performance and payment in full of the
Secured Obligations, hereby pledges ("verpandt") these IP Rights listed in the
annex to this letter to CAM IMPLANTS B.V. on the terms and conditions as set out
in the Deed of Pledge.

For purposes of Article 40 (2) of the Netherlands Patent Act 1910 and of Article
67 (2) of The Netherlands Patent Act 1995 the Pledgee, insofar necessary, hereby
chooses domicile at the Bureau lndustriele Eigendom in The Hague.

Yours sincerely,

CAM Acquisition B.V. (authorised signatories)

                                                                           E-209

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00041-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00041-of-00352.parquet"}]]