Document:

Industrial Building Lease

 Exhibit 10.1 
  
 INDUSTRIAL BUILDING LEASE 
  
 THIS LEASE is made this 24th day of October, 2002, by and between FCF PROPERTIES, LLC, a Colorado limited liability company (“Landlord”) and
AMERICAN COIN MERCHANDISING, INC., a Delaware corporation (“Tenant”), who hereby mutually covenant and agree as follows: 
  
 I. GRANT, TERM, DEFINITIONS AND BASIC LEASE PROVISIONS 
  
 1.1 Grant. Landlord, for and in consideration of the rents herein reserved and of the covenants and agreements herein contained on the part of
Tenant to be performed, hereby leases to Tenant, and Tenant hereby lets from Landlord, the real estate commonly known as 397 South Taylor, Louisville, Colorado and legally described on an exhibit which is attached hereto, identified as Exhibit A,
together with all improvements now located thereon, or to be located thereon during the term of this Lease, together with all appurtenances belonging to or in any way pertaining to the said premises (such real estate, improvements and appurtenances
hereinafter sometimes jointly or severally, as the context requires, referred to as ‘Leased Premises”). Anything contained herein to the contrary notwithstanding, the grant as set forth in this Section 1.1 and all of the provisions of this
lease are subject to the acquisition by Landlord of title to the fee of the Leased Premises not later than December 1, 2002. If such acquisition has not occurred by said date, this Lease shall be void and of no force and effect and the parties shall
not have liability to each other. The date that Landlord acquires fee simple title to the Leased Premises is hereinafter referred to as the “Commencement Date”. 
  
 1.2 Term. The term of this Lease shall commence on the Commencement Date and shall end on the last day of February,
2013 unless sooner terminated or extended as herein set forth. 
  
 1.3 Agent. As used in this Lease, the term “Agent” shall mean the agent of Landlord. Until otherwise designated by notice in writing from Landlord, Agent shall be Andrew Freeman Property Advisors, Inc. Tenant may rely upon
any consent or approval given in writing by Agent or upon notice from Agent or from the attorneys for Agent or Landlord. 
  
 1.4. Basic Lease Provisions. 
  

	 	(a)	Purpose (See Section 3.1): general office, or combination office and warehouse, or combination office, warehouse and distribution. 

  

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	 	(b)	Annual Base Rent (See Section 4.1): 

  

					
	 Period:

	  	 Annual Base Rent:

	  	 Monthly Installments

	 3/1/03 - the last day of February 2004
	  	$304,239.00	  	$25,353.25
	 3/1/04 - the last day of February 2005
	  	$313,288.20	  	$26,107.35
	 3/1/05 - the last day of February 2006
	  	$322,649.40	  	$26,887.45
	 3/1/06 - the last day of February 2007
	  	$332,322.60	  	$27,693.55
	 3/1/07 - the last day of February 2008
	  	$342,307.92	  	$28,525.66
	 3/1/08 - the last day of February 2009
	  	$352,605.24	  	$29,383.77
	 3/1/09 - the last day of February 2010
	  	$363,214.56	  	$30,267.88
	 3/1/10 - the last day of February 2011
	  	$374,136.00	  	$31,178.00
	 3/1/11 - the last day of February 2012
	  	$385,369.44	  	$32,114.12
	 3/1/12 - the last day of February 2013
	  	$396,914.88	  	$33,076.24

  

	 	(c)	Payee (See Section 4.1): FCF Properties, LLC. 

  

	 	(d)	Payee’s Address (See Sections 4.1 and 4.2): c/o Andrew Freeman Property Advisors, Inc., 1628 Walnut Street, Boulder, Colorado 80302. 

  

	 	(e)	Form of Insurance (See Article VI): The insurance specified in Sections 6.2.1 and 6.2.2 shall comply with the provisions of Section 6.3. 

  

	 	(f)	Security Deposit (See Section 20.1): $25,353.25 

  

	 	(g)	Tenant’s Address (for notices) (See Section 21.4): Prior to the Commencement Date: 5660 Central, Boulder Colorado 80301, and thereafter to the Leased Premises.

  

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	 	(h)	Landlord’s Address (for notices) (See Section 21.4): 1628 Walnut Street, Boulder Colorado, 80302. 

  

	 	(i)	Broker(s) (See Section 21.11): None 

  

	 	(j)	Guarantor’s Name and Address (See Separate Guaranty): None. 

  

	 	(k)	2003 Monthly payment for Expenses (subject to reconciliation as provided under Section 9.1(b): $9,200.00. 

  

	 	(l)	2003 Monthly payment for Impositions (subject to reconciliation as provided under Section 9.1(b): $4,960.00 

  

	 	(m)	2003 Monthly payment for Insurance Premiums (subject to reconciliation as provided under Section 9.1(b): $205.00. 

  

	 	(n)	Rider: Check here if a Rider is attached: 

  
 II. POSSESSION 
  
 2.1 Possession. Except as otherwise expressly provided herein (or by written instrument signed by Landlord or Agent) and except for Landlord’s
Construction (as defined in Section 22 hereof), Landlord shall deliver possession of the Leased Premises to Tenant on the Commencement Date in their condition as of the execution and delivery hereof, reasonable wear and tear excepted. 
  
 III. PURPOSE 
  
 3.1 Purpose. The Leased Premises shall be used and occupied only for
the Purpose set forth in Section 1.4(a) hereof, except that no such use shall (a) violate any certificate of occupancy or law, ordinance or other governmental regulation, or any covenants, conditions or restrictions of record, in effect from time to
time affecting the Leased Premises or the use thereof, (b) cause injury to the improvements, (c) cause the value or usefulness of the Leased Premises or any part thereof to diminish, (d) constitute a public or private nuisance or waste, (e)
authorize Tenant to use, treat, store or dispose of hazardous or toxic materials on the Leased Premises (except in accordance with Article XIII below), or to render the insurance on the Leased Premises void or the insurance risk more hazardous.
Tenant shall do no outside storage. 
  
 3.2 Prohibition of
Use. If the use of the Leased Premises should at any time during the Lease term be prohibited by law or ordinance or other governmental regulation, or prevented by injunction, this Lease shall not be thereby terminated, nor shall Tenant be
entitled by reason thereof to surrender the Leased Premises or to any abatement or reduction in rent, nor shall the respective obligations of the parties hereto be otherwise affected. 
  

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 IV. RENT 
  

4.1 Annual Base Rent. Beginning on March 1, 2003 (the “Rent Commencement Date”), Tenant shall pay Annual Base Rent as set forth in
Section 1.4(b) hereof payable monthly in advance in installments as set forth in said Section. Annual Base Rent, additional rent and other charges payable hereunder (collectively “Rent”) shall be paid to or upon the order of Payee at the
Payee’s address. Landlord shall have the right to change the Payee or the Payee’s Address by giving written notice thereof to Tenant. If Tenant occupies the Leased Premises for the purpose of conducting business therein prior to the
Commencement Date, Tenant shall pay Rent on a pro rata basis from the date of occupancy to the Commencement Date. All payments by Tenant shall be made without deduction, set off, discount or abatement in lawful money of the United States.

  
 4.2. Lock Box. Landlord may from time to time designate
a lock box collection agent for the collection of rents or other charges due Landlord. In such event, the date of payment shall be the date of receipt by the lock box collection agent of such payment (or the date of collection of any such sum if
payment is made in the form of a negotiable instrument thereafter dishonored upon presentment); however, for the purposes of this Lease, no such payment or collection shall be deemed “accepted” by Landlord if Landlord thereafter remits a
check payable to Tenant in the amount received by the lock box collection agent or, in the case of a dishonored instrument, within 21 days after collection. Neither the negotiation of Tenant’s negotiable instrument by the lock box collection
agent, nor the possession of the funds by Landlord during the twenty-one (21) day period, nor the return of any such sum to Tenant shall be deemed to be inconsistent with the rejection of Tenant’s tender of such payment for all purposes as of
the date of Landlord’s lock box collection agent’s receipt of such payment (or collection), nor shall any of such events be deemed to be a waiver of any breach by Tenant of any terms, covenants or conditions of this Lease nor a waiver of
any of Landlord’s rights or remedies. 
  
 4.3 Interest on
Late Payments. Each and every installment of Rent which shall not be paid when due shall bear interest at a rate per annum equal to five percent (5%) in excess of the announced base rate of interest of First National Bank of Colorado in effect
on the due date of such payment, from the date when the same is payable under the terms of this Lease until the same shall be paid. 
  
 V. IMPOSITIONS 
  
 5.1 Payment by Tenant. Commencing with the Rent Commencement Date, Tenant shall pay as additional Rent for the Leased Premises, in the manner
provided herein, all taxes and assessments, general and special, water rates and all other impositions, ordinary and extraordinary, of every kind and nature whatsoever, which may be levied, assessed, charged or imposed during the term of the Lease
upon the Leased Premises, or any part thereof, or upon any improvements at any time situated thereon, including without limitation, any assessment by any association of owners of property in the complex of which the Leased Premises are a part
(“Impositions”); provided, however, that Impositions levied against the Leased Premises shall be prorated between 
  

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 Landlord and Tenant as of the Rent Commencement Date for the first year of the Lease term and as of the expiration of the
Lease term for the last year of the Lease term (and shall be paid by Tenant upon such expiration based on Landlord’s reasonable estimate thereof and reconciled within sixty (60) days after the final amount of Impositions is determined for such
year). Impositions shall also include fees and costs incurred by Landlord during or prior to the Lease term for the purpose of contesting or protesting tax assessments or rates, to the extent such fees and costs do not exceed savings realized during
the term of the Lease and any extension thereof. The benefit of the provisions of any statute or ordinance permitting any assessment to be paid over a period of years shall be taken, and Tenant shall be obligated to pay, in the manner provided
below, only those installments falling due during the term of this Lease. 
  
 5.2 Alternative Taxes. If at any time during the term of this Lease the method of taxation prevailing at the commencement of the term hereof shall be altered so that any new tax, assessment, levy, imposition or
charge, or any part thereof, shall be measured by or be based in whole or in part upon the Lease, or the Leased Premises, or the Annual Base Rent, additional rent or other income therefrom and shall be imposed upon the Landlord, then all such taxes,
assessments, levies, impositions, or charges, or the part thereof, to the extent that they are so measured or based, shall be deemed to be included within the term Impositions for the purposes hereof to the extent that such Impositions would be
payable if the Leased Premises were the only property of Landlord subject to such Impositions, and Tenant shall pay and discharge the same as herein provided in respect of the payment of Impositions. There shall be excluded from Impositions all
federal income taxes, state and local net income taxes, federal excess profit taxes, franchise, capital stock and federal or state estate or inheritance taxes of Landlord. 
  
 5.3 Reserved. 
  
 5.4 Reserved. 
  
 5.5 Right to Contest. Tenant may, in good faith and with due diligence, contest Impositions by appropriate legal proceedings which shall have the
effect of preventing the collection of the Imposition so contested; provided that pending any such legal proceedings, Tenant shall give Landlord such security as may be deemed reasonably satisfactory to Landlord to insure payment of the amount of
the imposition and all interest and penalties thereon. Nothing in this section shall excuse Tenant from making the monthly deposits for Impositions set forth in Section 9.1(b) below. If, at any time during the continuance of such contest, the Leased
Premises or any part thereof is, in the judgment of Landlord, in imminent danger of being forfeited or lost, Landlord may use such security or deposit for the payment of such Imposition. 
  
 VI. RISK ALLOCATION AND INSURANCE 
  
 6.1 Allocation of Risks. The parties desire, to the extent permitted by law, to allocate certain risks of personal
injury, bodily injury or property damage, and risks of loss of real or personal property by reason of fire, explosion or other casualty, and to provide for the 
  

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 responsibility for insuring those risks. It is the intent of the parties that, to the extent any event is insured for or
required herein to be insured for, any loss, cost, damage or expense arising from such event, including, without limitation, the expense of defense against claims or suits, be covered by insurance, without regard to the fault of Tenant, its
officers, employees or agents (“Tenant Protected Parties”), and without regard to the fault of Landlord, its members, Agent, their respective partners, shareholders, members, agents, directors, officers and employees (“Landlord
Protected Parties”). As between Landlord Protected Parties and Tenant Protected Parties, such risks are allocated as follows: 
  
 (a) Tenant shall bear the risk of bodily injury, personal injury or death, or damage to the property, of third persons, occasioned by events occurring on
or about the Leased Premises, regardless of the party at fault. Said risks shall be insured as provided in Section 6.2.1(a). 
  
 (b) Tenant shall bear the risk of damage to Tenant’s contents, trade fixtures, machinery, equipment, furniture and furnishings in the Leased Premises
arising out of loss by the events required to be insured against pursuant to Sections 6.2.2(a), (b), (c) and (d). 
  
 (c) Tenant shall bear the risk of loss from all workers’ compensation claims. 
  
 (d) Tenant shall bear the risk of loss of damage to improvements on the Leased Premises arising out of loss by the events
required to be insured against pursuant to Sections 6.2.2(a), (b), (c), and (d) provided that Landlord shall carry the insurance specified in those Sections, unless any act or omission of Tenant shall prevent Landlord from obtaining such insurance,
in which event Tenant shall provide such insurance. 
  
 Notwithstanding the
foregoing, provided neither Landlord nor Tenant defaults in its obligation to carry insurance, if and to the extent that any loss occasioned by any event of the type to be insured against exceeds the coverage or the amount of insurance required to
be carried hereunder or such greater coverage or amount of insurance as is actually carried, or results from an event not required to be insured against or not actually insured against, the party at fault shall pay the amount not actually covered.

  
 6.2.1 Tenant shall procure and maintain policies of insurance,
at its own cost and expense, insuring: 
  
 (a) The Landlord
Protected Parties (as “named insureds”), and Landlord’s mortgagee, if any, of which Tenant is given written notice, and Tenant Protected Parties, from all claims, demands or actions made by or on behalf of any person or persons, firm
or corporation and arising from, related to or connected with the Leased Premises, for bodily injury to or personal injury to or death of any person, or more than one (1) person, or for damage to property in an amount of not less than $1,000,000
combined single limit per occurrence (with an aggregate limit of $2,000,000). Said insurance shall be written on an “occurrence” basis and not on a “claims 
  

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 made” basis. If at any time during the term of this Lease, Tenant owns or rents more than one location, the policy
shall contain an endorsement to the effect that the aggregate limit in the policy shall apply separately to each location owned or rented by Tenant. Landlord shall have the right, exercisable by giving written notice thereof to Tenant, to require
Tenant to increase such limit if, in Landlord’s reasonable judgment, the amount thereof is insufficient to protect the Landlord Protected Parties and Tenant Protected Parties from judgments which might result from such claims, demands or
actions. 
  
 (b) All contents and Tenant’s trade fixtures,
machinery, equipment, furniture and furnishings in the Leased Premises to the extent of at least ninety percent (90%) of their replacement cost under Standard Fire and Extended Coverage Policy and all other risks of direct physical loss as insured
against under Special Form (“all risk” coverage). Said insurance shall contain an endorsement waiving the insurer’s right of subrogation against any Landlord Protected Party, provided that such waiver of the right of subrogation shall
not he operative in any case where the effect thereof is to invalidate such insurance coverage or increase the cost thereof (except that Landlord shall have the right, within thirty (30) days following written notice, to pay such increased cost,
thereby keeping such waiver in full force and effect). 
  
 (c)
Tenant Protected Parties from all worker’s compensation claims. 
  
 6.2.2 Landlord’s Insurance. Subject to Section 6.1(d), Landlord shall procure and maintain policies of insurance, insuring: 
  
 (a) Landlord and Tenant against breakage of all plate glass utilized in the improvements on the Leased Premises. 
  
 (b) The improvements at any time situated upon the Leased Premises against
loss or damage by fire, lightning, wind storm, hail storm, aircraft, vehicles, smoke, explosion, riot or civil commotion as provided by the Standard Fire and Extended Coverage Policy and all other risks of direct physical loss as insured against
under Special Form (‘all risk’ coverage). The insurance coverage shall be for not less than 100% of the full replacement cost of such improvements with agreed amount endorsement, and building ordinance coverage. The full replacement cost
of improvements shall be designated annually by Landlord, in the good faith exercise of Landlord’s judgment. In the event that Tenant does not agree with Landlord’s designation, Tenant shall have the right to submit the matter to an
insurance appraiser reasonably selected by Landlord and paid for by Tenant. The insurance appraiser shall submit a written report of his appraisal and if said report discloses that the improvements are not insured as therein required, Tenant shall
promptly obtain the insurance required. Landlord shall be named as the insured and all proceeds of insurance shall be payable to Landlord. Said insurance shall contain an endorsement waiving the insurer’s right of subrogation against any
Landlord Protected Party or any Tenant Protected Party, provided that such waiver of the right of subrogation shall not he operative in any case where the effect thereof is to invalidate such insurance coverage or increase the cost thereof (except
that either party shall have the right, within thirty (30) days following written notice, to pay such increased cost, thereby keeping such waiver in full force and effect). 
  

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 (c) Flood or earthquake insurance whenever, in the reasonable judgment of Landlord, such protection is
necessary or if such insurance is required by Landlord’s Lender. 
  
 (d) Landlord’s business income, protecting Landlord from loss of rents and other charges during the period while the Leased Premises are untenantable due to fire or other casualty (for the period reasonably determined by Landlord).

  
 6.3 Form of Insurance. All of the aforesaid insurance
shall be in responsible companies. The insurer and the form, substance and amount (where not stated above) shall be satisfactory from time to time to Landlord and any mortgagee of Landlord, and shall unconditionally provide that it is not subject to
cancellation or non-renewal except after at least thirty (30) days prior written notice to Landlord and any mortgagee of Landlord. The insurance specified in Section 6.2.1(b) shall contain a mortgage clause satisfactory to Landlord’s mortgagee
and the insurance specified in Sections 6.2.2(a), (c) and (d) shall also insure Landlord’s mortgagee as required by Landlord’s mortgagee. Originals of Tenant’s insurance policies (or certificates thereof satisfactory to Landlord),
together with satisfactory evidence of payment of the premiums thereon, shall be deposited with Landlord at the Commencement Date and renewals thereof not less than thirty (30) days prior to the end of the term of such coverage. The insurance
referred to in Section 6.2.2(a), (b), (c), and (d) may contain an exclusion for terrorist activities. 
  
 6.4 Fire Protection. Tenant shall conform with all applicable fire codes of any governmental authority, and with the rules and regulations of
Landlord’s fire underwriters and their fire protection engineers, including, without limitation, the installation of adequate fire extinguishers. In the event that the Leased Premises are served by a sprinkler system, Tenant will, at all times
during the entire Lease term, cause the same to be served by a sprinkler monitoring system connected to the local Fire department or to a qualified monitoring service approved by Landlord. 
  
 VII. DAMAGE OR DESTRUCTION 
  
 7.1 Tenant’s Obligation to Rebuild. Tenant’s Obligation to
Rebuild. In the event of damage to, or destruction of, any improvements on the Leased Premises, or of the fixtures and equipment therein, by fire or other casualty, Tenant shall promptly, at its expense, repair, restore or rebuild the same to the
condition existing prior to the happening of such fire or other casualty; provided, however, that if the damage or destruction is material and substantial, Landlord shall have the right, subject to the consent of any first mortgagee whose consent
thereto is required, to terminate this Lease, effective on the date of such damage or destruction, by giving written notice thereof to Tenant within sixty (60) days after the event causing the damage or destruction. Except to the extent that
Landlord shall receive proceeds of insurance specified in Section 6.2.2(d), Rent shall not be reduced or abated during the period of such repair, restoration or rebuilding even if the improvements are not tenantable. 
  

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 7.2 Preconditions to Rebuilding. Before Tenant commences such repairing, restoration or rebuilding
involving an estimated cost of more than Fifty Thousand Dollars ($50,000.00), plans and specifications therefor, prepared by a licensed architect satisfactory to Landlord shall be submitted to Landlord for approval and Tenant shall furnish to
Landlord (a) an estimate of the cost of the proposed work, certified to by said architect; (b) satisfactory evidence of sufficient contractor’s commercial general liability insurance covering Landlord, builder’s risk insurance, and
worker’s compensation insurance; (c) a performance and payment bond satisfactory in form and substance to Landlord; and (d) such other security as Landlord may require to insure payment for the completion of all work free and clear of liens.

  
 7.3 Payment for Rebuilding. Provided that the insurer
does not deny liability as to the insureds, and provided Tenant is not then in default hereunder, all sums arising by reason of loss under the insurance referred to in Section 6.2.2(a), (b) and (c) shall be deposited with (he Depositary (as
hereinafter defined) to be available to Tenant for the work. Tenant shall deposit with the Depositary any excess cost of the work over the amount held by the Depositary as proceeds of the insurance within thirty (30) days after the date of the
determination of the cost of the work by the architect in accordance with Section 7.2(a) or, if the insurer has denied liability as to the insureds, or if Tenant is then in default hereunder, then Tenant shall deposit the full amount of the cost of
the work with the Depositary. Tenant shall diligently pursue the repair or rebuilding of the improvements in a good and workmanlike manner using only high quality union workers and materials. The Depositary shall pay out construction funds from time
to time on the written direction of the architect provided that the Depositary and Landlord shall first be furnished with waivers of lien, contractors, and subcontractors sworn statements and other evidence of cost and payments so that the
Depositary can verify that the amounts disbursed from time to time are represented by completed and in-place work, and that said work is free and clear of possible mechanics liens. No payment made prior to the final completion of the work shall
exceed ninety percent (90%) of the value of the work completed and in place from time to time. At all times the undisbursed balance remaining in the hands of Depositary shall be at least sufficient to pay for the cost of completion of the work free
and clear of liens. Any deficiency shall be paid into the Depositary by Tenant. Depositary, as used herein, shall be any first mortgagee of the Leased Premises, or the Landlord if there is no first mortgagee of the Leased Premises or if such first
mortgagee has refused to act as Depositary. 
  
 7.4 Excess
Receipts by Depositary. Any excess of money received from insurance remaining with the Depositary after the repair or rebuilding of improvements, if there be no default by Tenant in the performance of the Tenant’s covenants and agreements
hereunder, shall be paid to Tenant. 
  
 7.5 Failure to
Rebuild. If Tenant shall not enter upon the repair or rebuilding of the improvements within a period of sixty (60) days after damage or destruction by fire or otherwise, 
  

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 and prosecute the same thereafter with such dispatch as may be necessary to complete the same within a reasonable period
after said damage or destruction occurs, not to exceed one hundred eighty (180) days after the date of commencement of such repair or rebuilding, then, in addition to whatever other remedies Landlord may have either under this Lease, at law or in
equity, the money received by and then remaining in the hands of the Depositary shall be paid to and retained by Landlord as security for the continued performance and observance by Tenant of the Tenant’s covenants and agreements hereunder, or
Landlord may terminate this Lease and then be paid and retain the amount so held as damages resulting from the failure on the part of Tenant to comply with the provisions of this Article and may, in addition, pursue any other rights or remedies
available to Landlord hereunder, by operations of law or in equity. 
  
 VIII. CONDEMNATION 
  
 8.1 Taking of Whole.
If the whole of the Leased Premises shall be taken or condemned for a public or quasi public use or purpose by a competent authority, or if such a portion of the Leased Premises shall be so taken that as a result thereof the balance cannot be used
for the same purpose and with substantially the same utility to Tenant as immediately prior to such taking, or if the taking is material and substantial and Landlord elects (subject to the consent of any first mortgagee whose consent thereto is
required) to terminate this Lease, which election shall be made by giving written notice thereof to Tenant within thirty (30) days, after delivery of possession to the condemning authority, then in any of such events, the Lease shall terminate upon
delivery of possession to the condemning authority, and any award, compensation or damages (hereinafter sometimes called the “Award”) that is not specifically allocated by the condemning authority for Tenant’s relocation expenses
shall be paid to and be the sole property of Landlord whether the Award shall be made as compensation for diminution of the value of the leasehold estate or the fee of the Leased Premises, and Tenant hereby assigns to Landlord all of Tenant’s
right, title and interest in and to any and all of the Award. Tenant shall continue to pay Rent until the Lease is terminated and any Impositions and insurance premiums prepaid by Tenant or any unpaid Impositions or other charges which accrue prior
to the termination, shall be adjusted between the parties. 
  
 8.2
Partial Taking. If only a part of the Leased Premises shall be so taken or condemned, but the Lease is not terminated pursuant to Section 8.1 hereof, Tenant, at its sole cost and expense, shall repair and restore the Leased Premises and all
improvements thereon. There shall be no abatement or reduction in any Rent because of such taking or condemnation. Tenant shall promptly and diligently proceed to make a complete architectural unit of the remainder of the improvements, complying
with the procedure set forth in Section 7.2 For such purpose, and provided Tenant is not then in default hereunder, the amount of the Award relating to the improvements shall be deposited with the Depositary (as defined in Section 7.3 hereof) which
shall disburse the Award to apply on the cost of said repairing or restoration in accordance with the procedure set forth in Section 7.3. If Tenant does not make a complete architectural unit of the remainder of the improvements within a reasonable
period after such taking or condemnation, not to exceed one hundred eighty (180) days, then, in addition to whatever other remedies Landlord 
  

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 may have either under this Lease, at law or in equity, the money received by and then remaining in the custody of the
Depositary shall, at Landlord’s election be paid to and retained by Landlord, as liquidated damages resulting from failure of Tenant to comply with the provisions of this Section. Any portion of the Award as may not have to be expended for such
repairing or restoration shall be paid to Landlord. 
  
 IX.
PAYMENT OF EXPENSES, REAL ESTATE TAX AND INSURANCE 
 PREMIUM DEPOSITS, MAINTENANCE AND ALTERATIONS 
  
 9.1 Payment of Expenses, Real Estate Tax and Insurance Premium
Deposits. 
  
 (a) Expenses, as that term is used herein, shall
consist of all operating expenses of the Leased Premises which shall be paid by Landlord initially and shall be reimbursed by Tenant as hereinafter set forth. Operating expenses shall consist of the following: 
  
 all costs and expenses of: (i) operating, repairing, maintaining, upkeep
and replacing the exterior of the Leased Premises including the exterior of the building which constitutes a portion of the Leased Premises including, without limitation, upkeep and replanting of grass, trees, shrubs and landscaping; removal of
dirt, debris, obstructions and litter from the parking areas, landscaped areas, sidewalks and driveways; resurfacing, resealing, restriping, sweeping and snow and ice removal from the parking area, sidewalks and driveways; (ii) maintaining or
repairing heating, ventilating and air conditioning units, systems, equipment and facilities (“HVAC”) servicing the Leased Premises including, without limitation, replacement of filters, periodic inspections on any maintenance contract
(provided that Landlord shall not be obligated to carry any maintenance contracts); maintaining or repairing building signs; maintaining or repairing fire protection systems, monitoring and sprinkler systems; exterior painting; maintenance and
repairs to roof; repair, maintenance and replacement of damaged or broken glass or windows for the exterior of the building and maintaining and repairing of exterior doors; maintaining or repairing water and sewage disposal systems; storm drainage
systems (including, without limitation, a detention, drainage or pond areas located within the Leased Premises); irrigation and landscaping sprinkler system; association assessments, dues and fees; supplies and the cost of any rental of equipment in
implementing such services; professional management of the Leased Premises not to exceed five percent (5%) of Annual Base Rent; and all alterations, additions, improvements and other capital improvements for the Leased Premises in order to conform
to any laws, ordinance, rules, regulations or orders of any applicable governmental authority. As used herein, maintenance and repair shall include, without limitation, all ordinary and extraordinary structural and non-structural repairs and
replacements. Without limiting the generality of the foregoing, Expenses shall also include all amounts assessed under Section 9.2 of that certain Declaration of Protective Covenants recorded October 24, 1979 on Film 1089 at Reception No. 00367003.

  
 (b) Commencing with the Rent Commencement Date, Tenant agrees
to reimburse Landlord for all Expenses, all Impositions and the premiums for all insurance policies 
  

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 specified in Section 6.2.2 hereof (the “Insurance Premiums”). For each calendar year (all or any portion of
occurs during the term of this Lease from and after the Rent Commencement Date), Landlord shall provide Tenant a statement of projected Expenses, projected Impositions and projected Insurance Premiums prior to January 1 of such year or as soon
thereafter as is reasonably practicable except for the first calendar year. Tenant shall thereafter pay a projected additional rent for such year which shall be paid in monthly installments at the same time that Base Rent is paid hereunder and each
such installment shall equal one-twelfth (1/12) of projected Expenses, one-twelfth (1/12) of projected Impositions and one-twelfth (1/12) of projected Insurance Premiums. If the amount paid by Tenant pursuant to this subsection (b) is less than
actual Expenses, Tenant shall pay to Landlord within ten (10) days of statement receipt, the amount of the difference. If the amount paid by Tenant pursuant to this subparagraph (b) is less than actual Impositions, Tenant shall pay to Landlord
within ten (10) days of statement receipt the amount of the difference. If the amount paid by Tenant pursuant to this subparagraph (b) is less than actual Insurance Premiums, Tenant shall pay to Landlord within ten (10) days of statement receipt,
the amount of the difference. If the amount paid by Tenant pursuant to this subsection (d) is in excess of actual Expenses, the amount of such excess shall be credited to the next installment(s) of additional Rent pursuant to this subparagraph (b)
for Expenses, or if the term of this Lease has ended, shall first be credited to any amount due Landlord and then paid to Tenant. If the amount paid by Tenant pursuant to this subsection (b) is in excess of actual Impositions, the amount of such
excess shall be credited to the next installment(s) of additional Rent pursuant to this subparagraph (b) for Impositions, or if the term of this Lease has ended, shall first be credited to any amount due Landlord and then paid to Tenant. If the
amount paid by Tenant pursuant to this subsection (b) is in excess of actual Insurance, the amount of such excess shall be credited to the next installment(s) of additional Rent pursuant to this subparagraph (b) for Insurance Premiums, or if the
term of this Lease has ended, shall first be credited to any amount due Landlord and then paid to Tenant. Monthly payment for Expenses, Impositions and Insurance Premiums for the calendar year 2003 shall be the amounts specified in Section 1.04(k),
(l) and (m). Landlord shall have the reasonable right to adjust the monthly installments for Expenses, Impositions and Insurance Premiums. 
  
 9.2 Landlord’s Obligations for Maintenance, Repair and Replacement. 
  
 (a) Landlord, at its sole cost and expense (subject to reimbursement by Tenant and set forth in Section 9.1 above) shall
provide or cause to be provided and shall accomplish or cause to be accomplished all of the work and services described as Expenses, as reasonably determined by Landlord. 
  
 (b) Landlord may repair or replace any damage to the Leased Premises, including, without limitation, damage to the roof,
landscaping or exterior of the building of which the Leased Premises are a part, and to truck dock doors caused by or resulting from any act or omission of negligence of Tenant, its agents, employees, contractors, customers and invitees. Tenant
shall reimburse Landlord for Landlord’s costs and expenses incurred for repair or replacements made pursuant to this Section 9.2(b), within ten (10) days after Landlord bills Tenant therefor and such costs and expenses shall not constitute
Expenses. 
  

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 9.3 Tenant’s Maintenance. Tenant shall keep and maintain the entire interior of the Leased
Premises (including all components of mechanical systems (including HVAC) electrical and plumbing systems) located within the interior of the Leased Premises including all parts and conduits below the floor of the Leased Premises, clean and sanitary
and in good condition and repair, including, without limitation, carpet cleaning at least once each year, and necessary interior painting. 
  
 9.4 Additions, Improvements or Alterations (“Alterations”). Tenant shall not create any openings in the roof for exterior walls, or make
any other Alterations to the Leased Premises without Landlord’s prior written consent, which consent shall not be unreasonably withheld or delays. No consent shall be required for any Alterations reasonably expected to cost less than $10,000.

  
 9.5 Compliance with Law. Tenant shall not violate any
law, ordinance or other governmental regulation in effect from time to time affecting the Leased Premises or the use thereof. 
  
 X. ASSIGNMENT AND SUBLETTING 
  
 10.1 Consent Required. 
  
 (a) Tenant shall not, without Landlord’s prior written consent, (i) assign, convey or mortgage this Lease or any interest under it; (ii) sublet the
Leased Premises or any part thereof; (iii) amend a sublease previously consented to by Landlord; or (iv) permit the use or occupancy of the Leased Premises or any part thereof by anyone other than Tenant. If Tenant proposes to assign the Lease or
enter into any sublease of the Leased Premises, Tenant shall deliver written notice thereof to Landlord, together with a copy of the proposed assignment or sublease agreement at least thirty (30) days prior to the effective date of the proposed
assignment, or the commencement date of the term of the proposed sublease. Any proposed assignment or sublease shall be expressly subject to all of the terms, conditions and covenants of this Lease. Any proposed assignment shall contain an express
written assumption by assignee of all of Tenant’s obligations under this Lease. Any proposed sublease shall (i) provide that the sublessee shall procure and maintain policies of insurance as required of Tenant under the terms of Section 6.2.1
and 6.2.2 hereof, (ii) provide for a copy to Landlord of notice of default by either party, and (iii) otherwise be reasonably acceptable in form to Landlord. 
  
 (b) Landlord’s consent to any assignment or subletting shall not unreasonably be withheld. In making its determination as to whether to consent to
any proposed assignment or sublease, Landlord may consider, among other things, the creditworthiness and business reputation of the proposed assignee or subtenant, the intended manner of use of the Leased 
  

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 Premises by the proposed assignee or subtenant, the estimated vehicular traffic on or about the Leased Premises which
would be generated by the proposed assignee or subtenant or by its manner of use of the Leased Premises, and any other factors which Landlord may reasonably deem relevant. Tenant’s remedy, in the event that Landlord shall unreasonably withhold
its consent to an assignment or subletting, shall be limited to injunctive relief or declaratory judgment and in no event shall Landlord be liable for damages resulting therefrom. No consent by Landlord to any assignment or subletting shall be
deemed to be a consent to any further assignment or subletting or to any sub-subletting. 
  
 (c) In the event that Tenant proposes to assign the Lease or to enter into a sublease of all or substantially all of the Leased Premises, Landlord shall have the right, so long as any first mortgage of Landlord shall
consent in writing thereof, in lieu of consenting thereto, to terminate this Lease, effective as of the effective date of the proposed assignment or the commencement date of the proposed sublease, as the case may be. Landlord may exercise said right
by giving Tenant written notice thereof within twenty (20) days after receipt by Landlord of Tenant’s notice, given in compliance with Section 10.1(a) hereof, of the proposed assignment or sublease. In the event that Landlord exercises such
right, Tenant shall surrender the Leased Premises on the effective date of the termination and this Lease shall thereupon terminate. Landlord may, in the event of such termination, enter into a lease with any proposed assignee or subtenant for the
Leased Premises. 
  
 (d) In the event the Tenant subleases all or
any portion of the Leased Premises, Tenant shall pay to Landlord monthly, as additional rent hereunder, fifty percent (50%) of the amount calculated by subtracting from the Rent and other charges and consideration payable from time to time by the
subtenant to Tenant for said space, the amount of Rent payable by Tenant to Landlord under this Lease, allocated (based on the relative rentable square foot area of the total Leased Premises and of that portion of the Leased Premises so subleased by
Tenant) to the subleased portion of the Leased Premises. 
  
 (e)
No permitted assignment shall be effective and no permitted sublease shall commence unless and until any default by Tenant hereunder shall have been cured. No permitted assignment or subletting shall relieve Tenant from Tenant’s obligations and
agreements hereunder and Tenant shall continue to be liable as a principal and not as a guarantor or surety to the same extent as though no assignment or subletting had been made. 
  
 10.2 Merger; Consolidation or Asset Sale. Notwithstanding the provisions of Section 10.1 above, Tenant may, without
Landlord’s consent, assign this Lease to any corporation resulting from a merger or consolidation of the Tenant or to the purchaser in connection with a sale of substantially all of the assets of Tenant upon the following conditions: (a) that
the total assets and net worth of such assignee after such consolidation, merger or sale (as reasonably determined by Landlord) shall be equal to or more than that of Tenant immediately prior to such consolidation or merger or sale of assets; (b)
that Tenant is not at such time in default hereunder; and (c) that such successor shall execute an instrument in writing fully assuming all of the obligations and liabilities imposed upon Tenant hereunder and deliver the same to Landlord prior to
the effective date of such assignment. 
  

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 10.3 Voting Control of Tenant. If Tenant is a corporation, the shares of which, at the time of
execution of this Lease or during the term hereof are or shall be held by fewer than one hundred (100) persons, and if at any time during the term of this Lease the persons, firms or corporations who own a majority or controlling number of its
shares at the time of the execution of this Lease or following Landlord’s consent to a transfer of such shares cease to own such shares (except as a result of transfer by bequest or inheritance) and such cessation shall not first have been
approved in writing by Landlord, then such cessation shall, at the option of Landlord, be deemed a default by Tenant under this Lease, unless the conditions of section 10.2 above are met by the Tenant after such cessation. 
  
 10.4 Other Transfer of Lease. Tenant shall not allow or permit any
transfer of this Lease, or any interest hereunder, by operation of law, or mortgage, pledge, encumber or permit a lien on this Lease or any interest herein. 
  
 XI. LIENS AND ENCUMBRANCES 
  
 11.1 Encumbering Title. Tenant shall not do any act which shall in any way encumber the title of Landlord in and to the Leased Premises, nor shall
the interest or estate of Landlord in the Leased Premises in any way be subject to any claim by way of lien or encumbrance, whether by operation of law or virtue of any express or implied contract by Tenant. Any claim to, or lien upon, the Leased
Premises arising from any act or omission of Tenant shall accrue only against the leasehold estate of Tenant and shall be subject and subordinate to the paramount title and rights of Landlord in and to the Leased Premises. 
  
 11.2 Liens and Right to Contest. Tenant shall not permit the Leased
Premises to become subject to any mechanics’, laborers’ or materialmen’s lien on account of labor or material furnished to Tenant or claimed to have been furnished to Tenant in connection with work of any character performed or
claimed to have been performed on the Leased Premises by, or at the direction or sufferance of Tenant; provided, however, that Tenant shall have the right to contest, in good faith and with reasonable diligence, the validity of any such lien or
claimed lien if Tenant shall give to Landlord such security as may be deemed reasonably satisfactory to Landlord to assure payment thereof and to prevent any sale, foreclosure, or forfeiture of the Leased Premises by reason of nonpayment thereof;
provided further, that on final determination of the lien or claim for lien, Tenant shall immediately pay any judgment rendered, with all proper costs and charges, and shall have the lien released and any judgment satisfied. 
  

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 XII. UTILITIES 
  
 12.1 Utilities. Tenant shall purchase all utility services, including but not limited to fuel, water, sewerage and
electricity, from the utility or municipality providing such service, and shall pay for such services when such payments are due. 
  
 XIII. INDEMNITY 
  
 13.1 Indemnity. Tenant will protect, indemnify and save harmless Landlord, (for the purpose of this Article XIII only, the term
“Landlord” shall also include each mortgagee of Landlord and the agents of such mortgagee and any purchaser of the Real Estate) Protected Parties (as defined in Section 6.1) and Landlord’s mortgagee, if any, of which Tenant is given
written notice, from and against all liabilities, obligations, claims, damages, penalties, causes of action, costs and expenses (including without limitation, reasonable attorneys’ fees and expenses) imposed upon or incurred by or asserted
against the Landlord Protected Parties or any of them and Landlord’s mortgagee, if any, of which Tenant is given written notice by reason of (i) any failure on the part of Tenant to perform or comply with any of the terms of this Lease; or (ii)
performance of any labor or services or the furnishing of any materials or other property in respect of the Leased Premises or any part thereof. In case any action, suit or proceeding is brought against the Landlord Protected Parties or any of them
and Landlord’s mortgagee, if any, of which Tenant is given written notice by reason of any occurrence described in this Section 13.1, Tenant will, at Tenant’s expense, by counsel reasonably approved by Landlord, resist and defend such
action, suit or proceeding, or cause the same to be resisted and defended. The obligations of Tenant under this Section 13.1 shall survive the expiration or earlier termination of this Lease. 
  
 XIV. RIGHTS RESERVED TO LANDLORD 
  
 14.1 Rights Reserved to Landlord. Without limiting any other rights
reserved or available to Landlord under this Lease, at law or in equity, Landlord, on behalf of itself and Agent reserves the following rights to be exercised at Landlord’s election: 
  
 (a) To change the Street address of the Leased Premises; 
  
 (b) To inspect the Leased Premises upon reasonable notice to Tenant (except
in the case of emergency) and to make repairs or, to the extent required by law, additions or alterations, to the Leased Premises; 
  
 (c) Upon reasonable notice to Tenant, to show the Leased Premises to prospective purchasers, mortgagees, or other persons having a legitimate interest in
viewing the same, and, at any time within one (1) year prior to the expiration of the Lease term to persons wishing to rent the Leased Premises; 
  

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 (d) During the last year of the Lease term, to place and maintain the usual ‘For Rent’ sign in
or on the Leased Premises; 
  
 (e) If Tenant shall theretofore
have vacated the Leased Premises (but not earlier than during the last ninety (90) days of the Lease term), to decorate, remodel, repair, alter or otherwise prepare the Leased Premises for new occupancy; and 
  
 (f) To place and maintain “For Sale Signs” on exterior of the
building of which the Leased Premises is a part. 
  
 Landlord may enter upon the
Leased Premises for any and all of said purposes and may exercise any and all of the foregoing rights hereby reserved, during normal business hours upon reasonable prior notice, unless an emergency exists, without being deemed guilty of any eviction
or disturbance of Tenant’s use or possession of the Leased Premises, and without being liable in any manner to Tenant. 
  
 XV. QUIET ENJOYMENT 
  
 15.1 Quiet Enjoyment. So long as no Event of Default of Tenant has occurred, Tenant’s quiet and peaceable enjoyment of the Leased Premises
shall not be disturbed or interfered with by Landlord or by any person claiming by, through or under Landlord. 
  
 XVI. SUBORDINATION OR SUPERIORITY 
  
 16.1 Subordination or Superiority. If the mortgagee or trustee named in any first mortgage or first trust deed hereafter made shall agree that, if it becomes the owner of the Leased Premises by foreclosure or
deed in lieu of foreclosure, it will recognize the rights and interest of Tenant under the Lease and not disturb Tenant’s use and occupancy of the Leased Premises if and so long as no Event of Default of Tenant has occurred (which agreement
may, at such mortgagee’s option, require attornment by Tenant), then all or a portion of the rights and interests of Tenant under this Lease shall be subject and subordinate to such first mortgage or first trust deed and to any and all advances
to be made thereunder, and to the interest thereon, and all renewals, replacements and extensions thereof. Any such mortgagee or trustee may elect that, instead of making this Lease subject and subordinate to its first mortgage or first trust deed,
the rights and interest of Tenant under this Lease shall have priority over the lien of its mortgage or trust deed. Tenant agrees that it will, within ten (10) days after demand in writing, execute and deliver whatever instruments may be reasonably
required, either to make this Lease subject and subordinate to such a mortgage or trust deed, or to give the Lease priority over the lien of the mortgage or trust deed, whichever alternative may be elected by the mortgagee or trustee. Failure of
Tenant to execute and deliver such instrument(s) shall constitute an Event of Default hereunder and, in addition to all rights and remedies available to Landlord under this Lease or otherwise at law or in equity by reason of such Event of Default,
Tenant shall be liable for all loss, cost or damage suffered or incurred by Landlord (including, but without limitation, all actual and consequential damages suffered or incurred by Landlord) by reason of such failure of Tenant. 
  

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 XVII. SURRENDER 
  
 17.1 Surrender. Upon the termination of this Lease, whether by forfeiture, lapse of time or otherwise, or upon
termination of Tenant’s right to possession of the Leased Premises, Tenant will at once surrender and deliver up the Leased Premises, together with all improvements thereon, to Landlord, broom swept, in good condition and repair, reasonable
wear and tear excepted; conditions existing because of Tenant’s failure to perform maintenance, repairs or replacements as required herein, shall not be deemed “reasonable wear and tear”. Tenant shall deliver to Agent all keys to all
doors therein. As used herein, the term “Improvements” shall include, without limitation, all plumbing, lighting, electrical, heating, cooling and ventilating fixtures and equipment, and all Alterations (as said term is defined in Section
9.2 hereof) whether or not permitted under Section 9.4. All Alterations, temporary or permanent, made in or upon the Leased Premises by Tenant shall become Landlord’s property and shall remain upon the Leased Premises on any such termination
without compensation, allowance or credit to Tenant; provided, however, that Landlord shall have the right to require Tenant to remove any Alterations and restore the Leased Premises to their condition prior to the making of such Alterations,
repairing any damage occasioned by such removal and restoration. Said right shall be exercised by Landlord giving written notice thereof to Tenant on or before ninety (90) days after such termination. If Landlord requires removal of any Alterations
and Tenant does not make such removal in accordance with this Section at the time of such termination, or within ten (10) days after such request, whichever is later, Landlord may remove the same (and repair any damage occasioned thereby), and
dispose thereof or, at its election, deliver the same to any other place of business of Tenant or warehouse the same. Tenant shall pay the costs of such removal, repair, delivery and warehousing to Landlord on demand. 
  
 17.2 Removal of Tenant’s Property. Upon the termination of this
Lease by lapse of time, Tenant shall remove Tenant’s articles of personal property incident to Tenant’s business (Trade Fixtures”); provided, however, that Tenant shall repair any injury or damage to the Leased Premises which may
result from such removal, and shall restore the Leased Premises to the same condition as prior to the installation thereof. If Tenant does not remove Tenant’s Trade Fixtures from the Leased Premises prior to the expiration or earlier
termination of the Lease term, Landlord may, at its option, remove the same (and repair any damage occasioned thereby) and dispose thereof or deliver the same to any other place of business of Tenant or warehouse the same, and Tenant shall pay the
cost of such removal, repair, delivery and warehousing to Landlord on demand, or Landlord may treat such Trade Fixtures as having been conveyed to Landlord with this Lease as a Bill of Sale, without further payment or credit by Landlord to Tenant.

  
 17.3 Holding Over. Tenant shall have no right to occupy
the Leased Premises or any portion thereof after the expiration of the Lease or after termination of the Lease or of Tenant’s right to possession pursuant to Section 19.1 hereof. In the event Tenant or any party claiming by, 
  

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 through or under Tenant holds over, Landlord may exercise any and all remedies available to it at law or in equity to
recover possession of the Leased Premises, and for damages. For each and every month or partial month that Tenant or any party claiming by, through or under Tenant remains in occupancy of all or any portion of the Leased Premises after the
expiration of the Lease or after termination of the Lease or Tenant’s right to possession, Tenant shall pay, as minimum damages and not as a penalty, monthly rental at a rate equal to 150% of the rate of Rent payable by Tenant hereunder
immediately prior to the expiration or other termination of the Lease or of Tenant’s right to possession. The acceptance by Landlord of any lesser sum shall be construed as a payment on account and not in satisfaction of damages for such
holding over. 
  
 XVIII. ENVIRONMENTAL CONDITIONS

  
 18.1 “Environmental Condition” Defined.
As used in this Lease, the phrase ‘Environmental Condition’ shall mean: (a) any adverse condition relating to surface water, ground water, drinking water supply, land, surface or subsurface strata or the ambient air, and includes, without
limitation, air, land and water pollutants, noise, vibration, light and odors, or (b) any condition which may result in a claim of liability under the Comprehensive Environment Response Compensation and Liability Act, as amended
(“CERCLA”), or the Resource Conservation and Recovery Act (‘RCRA’), or any claim of violation of the Clean Air Act, the Clean Water Act, the Toxic Substance Control Act (TSCA”), or any claim of liability or of violation
under any federal statute hereafter enacted dealing with the protection of the environment or with the health and safety of employees or members of the general public, or under any rule, regulation, permit or plan under any of the foregoing, or
under any law, rule or regulation now or hereafter promulgated by the state in which the Leased Premises are located, or any political subdivision thereof, relating to such matters (collectively ‘Environmental Laws’). 
  
 18.2 Compliance by Tenant. Tenant shall, at all times during the Lease
term, comply with all Environmental Laws applicable to the Leased Premises and shall not, in the use and occupancy of the Leased Premises, cause or contribute to, or permit or suffer any other party to cause or contribute to any Environmental
Condition on or about the Leased Premises. Without limiting the generality of the foregoing, Tenant shall not, without the prior written consent of Landlord, receive, keep, maintain or use on or about the Leased Premises any substance as to which a
filing with a local emergency planning committee, the State Emergency Response Commission or the fire department having jurisdiction over the Leased Premises is required pursuant to 311 and/or 312 of CERCLA, as amended by the Superfund Amendment and
Reauthorization Act of 1986 (“SARA”) (which latter Act includes the Emergency Planning and Community Right-To-Know Act of 1986); in the event Tenant makes a filing pursuant to SARA, or maintains substances as to which a filing would be
required, Tenant shall simultaneously deliver copies thereof to Agent or notify Agent in writing of the presence of those substances. 
  
 18.3 Environmental Indemnity. Tenant will protect, indemnify and save harmless the Landlord Protected Parties (as defined in Section 6.1), Agent
and all of their respective agents, directors, officers and employees, and Landlord’s mortgagee, if any, of which Tenant is given 
  

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 written notice, from and against all liabilities, obligations, claims, damages, penalties, causes of action, costs and
expenses (including, without limitation, reasonable attorneys’ fees and expenses) of whatever kind or nature, contingent or otherwise, known or unknown, incurred or imposed, based upon any Environmental Laws or resulting from any Environmental
Condition on or about the Leased Premises which occurs or is contributed to (other than by Landlord or its agents) during the Lease term. In case any action, suit or proceeding is brought against any of the parties indemnified herein by reason of
any occurrence described in this Section 18.3, Tenant will, at Tenant’s expense, by counsel approved by Landlord, resist and defend such action, suit or proceeding, or cause the same to be resisted and defended. The obligations of Tenant under
this Section 18.3 shall survive the expiration or earlier termination of this Lease. 
  
 18.4 Testing and Remedial Work. Landlord may conduct tests on or about the Leased Premises for the purpose of determining the presence of any Environmental Condition. If such tests indicate the presence of an
Environmental Condition on or about the Leased Premises which occurs or is contributed to during the Lease term (other than by Landlord or its agents), Tenant shall, in addition to its other obligations hereunder, reimburse Landlord for the cost of
conducting such tests. Without limiting Tenant’s liability under Section 18.3 hereof, in the event of any such Environmental Condition, Tenant shall promptly and at its sole cost and expense, take any and all steps necessary to remedy the same,
complying with all provisions of applicable law and with Section 9.2(b) hereof, or shall, at Landlord’s election, reimburse Landlord for the cost to Landlord of remedying the same. The reimbursement shall be paid by Tenant to Landlord in
advance of Landlord’s performing such work based upon Landlord’s reasonable estimate of the cost thereof, and upon completion of such work by Landlord, Tenant shall pay to Landlord any shortfall promptly after Landlord bills Tenant
therefor, or Landlord shall promptly refund to Tenant any excess deposit, as the case may be. 
  
 XIX. REMEDIES 
  
 19.1
Defaults. Tenant agrees that any one or more of the following events shall be considered Events of Default as said term is used herein: 
  
 (a) Tenant shall be adjudged an involuntary bankrupt, or a decree or order approving, as properly filed, a petition or answer riled against Tenant asking
reorganization of Tenant under the Federal bankruptcy laws as now or hereafter amended, or under the laws of any state, shall be entered, and any such decree or judgment or order shall not have been vacated or set aside within sixty (60) days from
the date of the entry or granting thereof; or 
  
 (b) Tenant shall
file or admit the jurisdiction of the court and the material allegations contained in any petition in bankruptcy or any petition pursuant or purporting to be pursuant to the Federal bankruptcy laws as now or hereafter amended, or Tenant shall
institute any proceeding or shall give its consent to the institution of any proceedings for any relief of Tenant under any bankruptcy or insolvency laws or any laws relating to the relief of debtors, readjustment of indebtedness, reorganization,
arrangements, composition or extension; or 
  

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 (c) Tenant shall make any assignment for the benefit of creditors or shall apply for or consent to the
appointment of a receiver for Tenant or any of the property of Tenant; or 
  
 (d) The Leased Premises are levied upon by any revenue officer or similar officer; or 
  
 (e) A decree or order appointing a receiver of the property of Tenant shall be made and such decree or order shall not have been vacated or set aside
within sixty (60) days from the date of entry or granting thereof; or 
  
 (f) Tenant shall abandon the Leased Premises or vacate the same during the term hereof; or 
  
 (g) Tenant shall default in any payment of Rent or in any other payment required to be made by Tenant hereunder when due as herein provided (all of which
other payments shall be deemed ‘additional rent’ payable hereunder), or shall default under Sections 6.2.1, 6.2.2 or Section 21.2 hereof, and any such default shall continue for five (5) days after notice thereof in writing to Tenant; or

  
 (h) Tenant shall fail to contest the validity of any lien or
claimed lien and give security to Landlord to assure payment thereof, or, having commenced to contest the same and having given such security, shall fail to prosecute such contest with diligence, or shall fail to have the same released and satisfy
any judgment rendered thereon, and such default continues for ten (10) days after notice thereof in writing to Tenant; or 
  
 (i) Tenant shall default in keeping, observing or performing any of the other covenants or agreements herein contained to be kept, observed and performed
by Tenant, and such default shall continue for thirty (30) days after notice thereof in writing to Tenant or shall exist at the expiration of the Lease term; or 
  

(j) Tenant shall default in keeping, observing or performing any covenant or agreement herein contained to be kept, observed and performed by Tenant,
which default may result in an imminent risk of damage to property (including without limitation the Leased Premises or the improvements thereon) or injury to or death of persons, and such default shall not be cured immediately upon notice thereof
to Tenant (which notice may be oral); or 
  
 (k) Tenant shall
default (with time to cure expired) under any other lease made by Tenant for any other premises owned by Landlord or managed by Agent or by any successor to Agent as the agent for Landlord or the beneficiary of Landlord; or 
  
 (l) Tenant shall repeatedly be late in the payment of rent or other charges
required to be paid hereunder or shall repeatedly default in the keeping, observing, or performing of any other covenants or agreements herein contained to be kept, observed or performed by 
  

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 Tenant (provided notice of such payment or other defaults shall have been given to Tenant, but whether or not Tenant
shall have timely cured any such payment or other defaults of which notice was given). 
  
 19.2 Remedies. Upon the occurrence of any one or more Events of Default, Landlord may at its election terminate this Lease or terminate Tenant’s right to possession only, without terminating the Lease.
Upon termination of the Lease, or upon any termination of Tenant’s right to possession without termination of the Lease, Tenant shall surrender possession and vacate the Leased Premises immediately, and deliver possession thereof to Landlord,
and hereby grants to Landlord the full and free right, without demand or notice of any kind to Tenant (except as hereinabove expressly provided for), to enter into and upon the Leased Premises in such event with or without process of law and to
repossess the Leased Premises as Landlord’s former estate and to expel or remove Tenant and any others who may be occupying or within the Leased Premises without being deemed in any manner guilty of trespass, eviction, or forcible entry or
detainer, without incurring any liability for any damage resulting therefrom and without relinquishing Landlord’s rights to Rent or any other right given to Landlord hereunder or by operation of law. Upon termination of the Lease, Landlord
shall be entitled to recover as damages all Rent and other sums due and payable by Tenant on the date of termination, plus (a) an amount equal to the value, on an annual basis, of the excess (discounted to present value at six percent (6%) annually)
of (i) the Rent and other sums provided herein to be paid by Tenant for the residue of the stated term hereof over (ii) the fair rental value of the Leased Premises for the residue of the stated term taking into account the time and expenses
necessary to obtain a replacement tenant or tenants, including expenses hereinafter described relating to recovery of the Leased Premises, preparation for reletting and for reletting itself), and (b) the cost of performing any other covenants to be
performed by Tenant. If Landlord elects to terminate Tenant’s right to possession only without terminating the Lease, Landlord may, at Landlord’s option, enter on to the Leased Premises, remove Tenant’s signs and other evidences of
tenancy, and take and hold possession thereof as hereinafter provided, without such entry and possession terminating the Lease or releasing Tenant, in whole or in part, from Tenant’s obligations to pay the Rent and other sums provided herein to
be paid by Tenant for the full term or from any other of its obligations under this Lease. Landlord may relet all or any part of the Leased Premises for such Rent and upon such terms as shall be satisfactory to Landlord (including the right to relet
the Leased Premises as a part of a larger area the right to change the character or use made of the Leased Promises). For the purpose of such reletting, Landlord may decorate or make any repairs, changes, alterations or additions in or to the Leased
Premises that may be necessary or convenient. If Landlord does not relet the Leased Premises, Tenant shall pay to Landlord on demand damages equal to the amount of the Rent, and other sums provided herein to be paid by Tenant for the remainder of
the Lease term. If the Leased Premises are relet and a sufficient sum shall not be realized from such reletting after paying all of the expenses of such decorations, repairs, changes, alterations, additions, the expenses of such reletting and the
collection of the rent accruing therefrom (including, but not by way of limitation, attorneys’ fees and brokers’ commissions), to satisfy the Rent and other sums herein provided to be paid for the remainder of the Lease term, Tenant shall
pay to Landlord on demand any deficiency and Tenant agrees that Landlord may file suit to 
  

 22 

 recover any Rent or other sums falling due under the terms of this Section from time to time. Landlord shall use
reasonable efforts to mitigate its damages arising out of Tenant’s default; Landlord shall not be deemed to have failed to use such reasonable efforts by reason of the fact that Landlord has leased or sought to lease other vacant premises owned
by Landlord, in preference to reletting the Leased Premises, or by reason of the fact that Landlord has sought to relet the Leased Premises at a rental rate higher than that payable by Tenant under the Lease (but not in excess of the then current
market rental rate). 
  
 19.3 Tenant’s Opportunity to
Cure. If Tenant defaults under Section 19.1(i), and such default cannot with due diligence be cured within a period of thirty (30) days, and if notice thereof in writing shall have been given to Tenant, and if Tenant, prior to the expiration of
thirty (30) days from and after the giving of such notice, commences to eliminate the cause of such default and proceeds diligently and with reasonable dispatch to take all steps and do all work required to cure such default and does so cure such
default, then an Event of Default shall not be deemed to have occurred; provided, however, that Tenant’s right to cure hereunder shall not extend beyond the expiration of the Lease term, and provided further that the curing of any default in
such manner shall not be construed to limit or restrict Landlord’s remedies for any other default which becomes an Event of Default. 
  
 19.4 Landlord’s Right to Cure. Landlord may, but shall not be obligated to, cure any default by Tenant (specifically including, but not by way
of limitation, Tenant’s failure to obtain insurance, make repairs, or satisfy lien claims) and whenever Landlord so elects, all costs and expenses paid by Landlord in curing such default, including without limitation reasonable attorneys’
fees, shall be so much additional rent due on the next rent date after such payment together with interest (except in the case of said attorney’s fees) at the highest rate then payable by Tenant in the state in which the Leased Premises are
located or, in the absence of such a maximum rate, at a rate per annum equal to two per cent (2%) in excess of the announced base rate or equivalent rate of interest of First National Bank of Colorado (as publicly announced by said bank) in effect
on the date of such advance, from the date of the advance to the date of repayment by Tenant to Landlord. 
  
 19.5 Remedies Cumulative. No remedy herein or otherwise conferred upon or reserved to Landlord shall be considered to exclude or suspend any other
remedy but the same shall be cumulative and shall be in addition to every other remedy given hereunder, or now or hereafter existing at law or in equity or by statute, and every power and remedy given by this Lease to Landlord may be exercised from
time to time and so often as occasion may arise or as may be deemed expedient. 
  
 19.6 No Waiver. No delay or omission of Landlord to exercise any right or power arising from any default shall impair any such right or power or be construed to be a waiver of any such default or any
acquiescence therein. No waiver of any breach of any of the covenants of this Lease shall be construed, taken or held to be a waiver of any other breach, or as a waiver, acquiescence in or consent to any further or succeeding breach of the same
covenant. The 
  

 23 

 acceptance by Landlord of any payment of Rent after the termination by Landlord of this Lease or of Tenant’s right
to possession hereunder shall not, in the absence of agreement in writing to the contrary by Landlord, be deemed to restore this Lease or Tenant’s right to possession hereunder, as the case may be, but shall be construed as a payment on
account, and not in satisfaction of damages due from Tenant to Landlord. 
  
 XX. SECURITY DEPOSIT 
  
 20.1 Security
Deposit. To secure the faithful performance by Tenant of all the terms, covenants and conditions in this Lease set forth and contained on the part of the Tenant to be fulfilled, kept, observed and performed, including, but without limiting the
generality of the foregoing, such terms, covenants and conditions which become applicable upon the expiration or termination of the same or upon termination of Tenant’s right to possession pursuant to Section 19.2 of the Lease, Tenant has
deposited herewith the Security Deposit with Agent on the understanding: (a) that the Security Deposit or any portion thereof not previously applied, or from time to time such other portions thereof, may be applied to the curing of any default that
may then exist, without prejudice to any other remedy or remedies which Landlord may have on account thereof, and upon such application Tenant shall pay Agent on demand the amount so applied which shall be added to the Security Deposit so the same
may be restored to its original amount; (b) that should the Leased Premises be conveyed by Landlord or should Agent cease to be the agent of the beneficiary or beneficiaries of Landlord, the Security Deposit or any portion thereof not previously
applied may be turned over to Landlord’s grantee or the new agent, as the case may be, and if the same be turned over as aforesaid, Tenant hereby releases Landlord and Agent from any and all liability with respect to the Security Deposit and/or
its application or return, and Tenant agrees to look to such grantee or new agent, as the case may be, for such application or return; (c) that Landlord shall have no personal liability with respect to said sum and Tenant shall look exclusively to
Agent or its successors pursuant to subsection (b) hereof for return of said sum when Tenant is entitled hereunder to such return; (d) that Agent or its successor shall not be obligated to hold the Security Deposit as a separate fund, but on the
contrary may commingle the same with its other funds; (e) that if Tenant shall faithfully fulfill, keep, perform and observe all of the covenants, conditions, and agreements in this Lease set forth and contained on the part of Tenant to be
fulfilled, kept, performed and observed, the Security Deposit or the part or portion thereof not previously applied shall be returned to the Tenant without interest no later than thirty (30) days after the expiration of the term of this Lease or any
renewal or extension thereof, provided Tenant has vacated the Leased Premises and surrendered possession thereof to Landlord at the expiration of said term or any extension or renewal thereof as provided herein; (f) in the event that Landlord
terminates the Lease or Tenant’s right to possession pursuant to Section 19.2 of this Lease, Agent may apply the Security Deposit against all damages suffered to the date of such termination and/or may retain the Security Deposit to apply
against such damages as may be suffered or shall accrue thereafter by reason of Tenant’s default; and (g) in the event any bankruptcy, insolvency, reorganization or other creditor debtor proceedings shall be instituted by or against Tenant, or
its successors or assigns, the Security Deposit shall be deemed to be applied first to the payment of any Rent and/or other sums due Landlord for all periods prior to the institution of such proceedings, and the balance, if any, of the Security
Deposit may be retained or paid to Landlord in partial liquidation of Landlord’s damages. 
  

 24 

 XXI. MISCELLANEOUS 
  
 21.1 Non Merger. Notwithstanding the acquisition of the Leased Premises and/or Real Estate or the beneficial interest
or ownership thereof by the Lessee or the fact that the interests of Lessor and Lessee hereunder shall be held by the same person or persons, there shall not be a merger of leasehold estate into the fee and this Lease shall remain valid and in full
force and effect in accordance with its terms. 
  
 21.2
Tenant’s Statement. Tenant shall furnish to Landlord, within ten (10) days after written request therefor from Landlord, a copy of the then most recent audited and certified statement of Tenant and Guarantor, if any. It is mutually
agreed that Landlord may deliver a copy of such statements to any mortgagee or prospective mortgagee of Landlord, or any prospective purchaser of the Leased Premises, but otherwise Landlord shall treat such statements and information contained
therein as confidential. 
  
 21.3 Estoppel Certificates.
Tenant shall at any time and from time to time upon not less than ten (10) days prior written request from Landlord, execute, acknowledge and deliver to Landlord, in form reasonably satisfactory to Landlord and/or Landlord’s mortgagee, a
written statement certifying (if true) that Tenant has accepted the Leased Premises, that this Lease is unmodified and in full force and effect (or, if there have been modifications, that the same is in full force and effect as modified and stating
the modifications), that Landlord is not in default hereunder, the date to which Rent has been paid in advance, if any, and such other accurate certifications as may reasonably be required by Landlord or Landlord’s mortgagee, agreeing to give
copies to any mortgagee of Landlord of all notices by Tenant to Landlord and agreeing to afford Landlord’s mortgagee a reasonable opportunity to cure any default of Landlord. It is intended that any such statement delivered pursuant to this
Section may be relied upon by any prospective purchaser or mortgagee of the Leased Premises and their respective successors and assigns. 
  
 21.4 Amendments Must Be In Writing. None of the covenants, terms or conditions of this Lease, to be kept and performed by either party, shall in
any manner be altered, waived, modified, changed or abandoned except by a written instrument, duly signed and delivered by the other party. 
  
 21.5 Notices. All notices to or demands upon Landlord or Tenant desired or required to be given under any of the provisions hereof shall be in
writing. Any notices or demands from Landlord to Tenant shall be deemed to have been duly and sufficiently given when received or refused if sent by United States registered or certified mail in an envelope properly stamped and addressed or if sent
by courier service, with receipt, to Tenant at Tenant’s Address or at such other address as Tenant may theretofore have designated by written notice to Landlord, and any notices 
  

 25 

 or demands from Tenant to Landlord shall be deemed to have been duly and sufficiently given if mailed by United States
registered or certified mail in an envelope properly stamped and addressed or sent by courier service, with receipt, to Landlord at Landlord’s Address or at such other address or to such other agent as Landlord or Agent may theretofore have
designated by written notice to Tenant, with a copy to any first mortgagee of the Leased Premises, the identity and address of which Tenant shall have received written notice. 
  
 21.6 Short Form Lease. This Lease shall not be recorded, but the parties agree, at the request of either of them, to
execute a Short Form Lease for recording, containing the names of the parties, the legal description and the term of the Lease. 
  
 21.7 Time of Essence. Time is of the essence of this Lease, and all provisions herein relating thereto shall be strictly construed. 
  
 21.8 Relationship of Parties. Nothing contained herein shall be deemed
or construed by the parties hereto, or by any third party, as creating the relationship of principal and agent or of partnership, or of joint venture, by the parties hereto, it being understood and agreed that no provision contained in this Lease
nor any acts of the parties hereto shall be deemed to create any relationship other than the relationship of landlord and tenant. 
  
 21.9 Captions. The captions of this Lease are for convenience only and are not to be construed as part of this Lease and shall not be construed as
defining or limiting in any way the scope and intent of the provisions hereof. 
  
 21.10 Severability. If any term or provision of this Lease shall to any extent be held invalid or unenforceable, the remaining terms and provisions of this Lease shall not be affected thereby, but each term and
provision of this Lease shall be valid and be enforced to the fullest extent permitted by law. 
  
 21.11 Law Applicable. This Lease shall be construed and enforced in accordance with the laws of the state where the Leased Premises are located. 
  
 21.12 Covenants Binding on Successors. All of the covenants, agreements, conditions and undertakings contained in
this Lease shall extend and inure to and be binding upon the heirs, executors, administrators, successors and assigns of the respective parties hereto, the same as if they were in every case specifically named, and wherever in this Lease reference
is made to either of the parties hereto, it shall be held to include and apply to, wherever applicable, the heirs, executors, administrators, successors and assigns of such party. Nothing herein contained shall be construed to grant or confer upon
any person or persons, firm, corporation or governmental authority, other than the parties hereto, their heirs, executors, administrators, successors and assigns, any right, claim or privilege by virtue of any covenant, agreement, condition or
undertaking in this Lease contained. 
  

 26 

 21.13 Brokerage. Tenant warrants that it has had no dealings with any broker or agent in
connection with this Lease other than Broker(s), whose commission Landlord covenants and agrees to pay in the amount agreed to by Landlord. Tenant covenants to pay, hold harmless, indemnify and defend Landlord from and against any and all costs,
expenses or liability for any compensation, commissions and charges claimed by any broker or agent other than Broker(s) with respect to this Lease or the negotiation thereof. 
  
 21.14 Landlord Means Owners. The term “Landlord” as used in this Lease, so far as covenants or obligations
on the part of the Landlord are concerned, shall be limited to mean and include only the owner or owners at the time in question of the fee of the Leased Premises, and in the event of any transfer or transfers of the title to such fee, Landlord
herein named (and in case of any subsequent transfer or conveyances, the then grantor) shall be automatically freed and relieved, from and after the date of such transfer or conveyance, of all liability as respects the performance of any covenants
or obligations on the part of Landlord contained in this Lease thereafter to be performed; provided that any funds in the hands of such Landlord or the then grantor at the time of such transfer, in which Tenant has an interest, shall be turned over
to the grantee, and any amount then due and payable to Tenant by Landlord or the then grantor under any provisions of this Lease shall be paid to Tenant. 
  
 21.15 Lender’s Requirements. If any mortgagee or committed financier of Landlord should require, as a condition precedent to the closing of
any loan or the disbursal of any money under any loan, that this Lease be amended or supplemented in any manner (other than in the description of the Leased Premises, the term, the purpose or the rent or other charges hereunder, or in any other
regard as will substantially or materially affect the rights of Tenant under this Lease), Landlord shall give written not ice thereof to Tenant, which notice shall be accompanied by a Lease Supplement Agreement embodying such amendments and
supplements. Tenant shall, within ten (10) days after the effective date of Landlord’s notice, either consent to such amendments and supplements (which consent shall not be unreasonably withheld) and execute the tendered Lease Supplement
Agreement, or deliver to Landlord a written statement of its reason or reasons for refusing to so consent and execute. Failure of Tenant to respond within said ten (10) day period shall be a default under this Lease without further notice. If
Landlord and Tenant are then unable to agree on a Lease Supplement Agreement satisfactory to each of them and to the lender within thirty (30) days after delivery of Tenant’s written statement, Landlord shall have the right to terminate this
Lease within sixty (60) days after the end of said thirty (30) day period. 
  
 21.16 Signs. Tenant shall install no exterior sign without Landlord’s prior written approval of detailed plans and specifications therefor. If Landlord has a standard form of identity sign for tenants in
the industrial park of which the Leased Premises are a part, and if Tenant desires to have an identity sign on the Leased Premises, Tenant shall advise Landlord of the name it desires to have on its sign, and Landlord shall install its standard sign
showing such name. Tenant shall reimburse Landlord for Landlord’s costs of producing and erecting said sign within ten (10) days after being billed therefor by Landlord. 
  

 27 

 21.17 Force Majeure. Landlord shall not be deemed in default with respect to any of the terms,
covenants and conditions of this Lease on Landlord’s part to be performed, if Landlord’s failure to timely perform same is due in whole or in part to any strike, lockout, labor trouble (whether legal or illegal), civil disorder, failure of
power, restrictive governmental laws and regulations, riots, insurrections, war, shortages, accidents, casualties, acts of God, acts caused directly by Tenant or Tenant’s agents, employees and invitees, or any other cause beyond the reasonable
control of Landlord. 
  
 21.18 Landlord’s Expenses.
Except as may be otherwise expressly set forth in any settlement agreement between the parties in respect of any dispute hereunder, Tenant agrees to pay on demand Landlord’s reasonable expenses, including reasonable attorneys’ fees,
expenses and administrative hearing and court costs incurred either directly or indirectly in enforcing any obligation of Tenant under this Lease, in curing any default by Tenant under this Lease, in connection with appearing, defending or otherwise
participating in any action or proceeding arising from the filing, imposition, contesting, discharging or satisfaction of any lien or claim for lien, in defending or otherwise participating in any legal proceedings initiated by or on behalf of
Tenant wherein Landlord is not adjudicated to be in default under this Lease, or in connection with any investigation or review of any conditions or documents in the event Tenant requests Landlord’s agreement, approval or consent to any action
of Tenant which may be desired by Tenant or required of Tenant hereunder. Notwithstanding the foregoing, to the extent either party files an action hereunder that proceeds to verdict, the non-prevailing party shall pay (within 30 days of such
verdict) the expenses, including reasonable attorneys’ fees, expenses and administrative hearing and court costs of the prevailing party relative to such action. 
  
 21.19 Execution or Lease by Landlord. The submission of this document for examination and negotiation does not
constitute an offer to lease, or a reservation of, or option for, the Leased Premises and this document shall become effective and binding only upon the execution and delivery hereof by Tenant and by Landlord. All negotiations, considerations,
representations and understandings between Landlord and Tenant are incorporated herein. 
  
 21.20 Tenant’s Authorization. If Tenant is a corporation, partnership, association, limited liability company or any other entity, Tenant shall furnish to Landlord, within ten (10) days after written
request therefor from Landlord, certified resolutions of Tenant’s directors or other governing person or body authorizing execution and delivery of this Lease and performance by Tenant of its obligations hereunder, and evidencing that the
person who physically executed the Lease on behalf of Tenant was duly authorized to do so. 
  
 21.21 Exculpatory. Tenant shall look solely to the then interest of Landlord in the Premises, or of any successor in interest to Landlord, as owner of said Premises, for the satisfaction of any remedy of Tenant
for failure to perform any of Landlord’s obligations under this Lease, either express or implied, or under any law whether now existing or hereinafter enacted. Neither Landlord nor any disclosed or undisclosed principal or member of Landlord
(or any officer, director, stockholder, partner or agent of Landlord or any such principal or member) nor any successor of any of them shall have any personal liability for any such failure under this Lease or otherwise. 
  

 28 

 21.22 Option to Extend. 
  
 (a) Provided that no Event of Default shall have occurred which remains uncured and further provided that Tenant or any
permitted assignee or sublessee shall be in possession of the Leased Premises, Tenant shall have the right, exercisable by giving written notice (“First Renewal Notice”) thereof to Landlord at least nine (9) months but not before twelve
(12) months prior to the expiration of the original Term of this Lease to extend the Term of this Lease for an additional term of sixty (60) calendar months (“First Renewal Period”) upon all of the terms, covenants and conditions contained
in this Lease, except that the Annual Base Rent for the First Renewal Period shall be as follows: 
  

							
	 Period:

	  	Annual Base Rent:

	  	Monthly
Installments

	 3/1/13 - the last day of February 2014
	  	$	408,822.33	  	$	34,068.53
	 3/1/14 - the last day of February 2015
	  	$	421,087.00	  	$	35,090.58
	 3/1/15 - the last day of February 2016
	  	$	433,719.61	  	$	36,143.30
	 3/1/16 - the last day of February 2017
	  	$	446,731.19	  	$	37,227.60
	 3/1/17 - the last day of February 2018
	  	$	460,133.13	  	$	38,344.43

  
 (b) Provided that no
Event of Default shall have occurred which remains uncured, and further provided that Tenant or any permitted assignee or sublessee shall be in possession of the Leased Premises, and further provided the Term of this Lease has been extended for the
First Renewal Period, Tenant shall have the right, exercisable by giving notice (“Second Renewal Notice”) thereof to Landlord at least nine (9) months but not before twelve (12) months prior to the expiration of the First Renewal Period,
to extend the term of this Lease for an additional term of sixty (60) calendar months (“Second Renewal Period”) upon the terms, covenants and conditions contained in this Lease, except that the Annual Base Rent for the Second Renewal
Period shall be as follows: 
  

							
	 Period:

	  	Annual Base Rent:

	  	Monthly
Installments

	 3/1/18 - the last day of February 2019
	  	$	473,937.12	  	$	39,494.76
	 3/1/19 - the last day of February 2020
	  	$	488,155.24	  	$	40,679.60
	 3/1/20 - the last day of February 2021
	  	$	502,799.89	  	$	41,899.99
	 3/1/21 - the last day of February 2022
	  	$	517,883.89	  	$	43,156.99
	 3/1/22 - the last day of February 2023
	  	$	533,420.40	  	$	44,451.70

  

 29 

 XXII. WORK LETTER 
  
 22. Work Letter. 
  
 (a) Tenant has or shall cause RVP Architectural. (the “Architect”) to prepare plans and specifications for the construction of the Work (as
hereinafter defined). Said plans and specifications are hereinafter referred to as Construction Documents. 
  
 The Construction Documents shall describe all items and materials which constitute the Work (as hereinafter defined). The Construction Documents, the
Contract (as hereinafter defined) and the Contractor (as hereinafter defined) shall be subject to the Landlords reasonable approval; and if Landlord does not approve the same, Landlord shall advise Tenant of the reason for the disapproval. If
Landlord does not disapprove the Contract or the Contractor within ten (10) business days following the receipt thereof by Landlord, the same shall be deemed approved by Landlord. 
  
 (b) It is understood and agreed that Landlord will enter into a Contract with the Contractor for the installation in the
Premises of the items and materials described in Construction Documents (the installation of said items and materials being herein referred to as the “Work”). The Work shall be performed by a general contractor (“Contractor”)
selected by Tenant under a so-called “lump sum” or “agreed amount” contract (“Contract”). Without limiting the generality of the foregoing, the Contract shall provide that the Landlord shall have no liability thereunder
for that portion of the cost of the Work equal to the Tenant’s Contribution. Upon the request of Tenant and provided that the Contract and the Contractor have been approved by Landlord, Landlord shall enter into the Contract with the
Contractor. 
  

 30 

 For the purpose of this Section 22, the term “cost of construction” shall mean the cost of
construction as set forth in the Contract with the Contractor, including the cost of any permits by any governmental authority having jurisdiction and the cost of preparing the Construction Documents. 
  
 In the event a Tenant’s Contribution is required, prior to the
commencement of the construction of the Work Landlord shall advise Tenant of the Cost of Construction which advice shall include evidence of the cost of the permits referred to above. Landlord agrees to pay the Contractor for the value of the Work
performed by the Contractor except for the Tenant’s Contribution and except for any Tenant’s Extra. Landlord shall make no disbursements to the Contractor unless the same have first been approved by the Tenant. To the extent that the Cost
of Construction exceeds $706,159 (such excess being herein called the Tenant’s Contribution”), Tenant shall pay the Tenant’s Contribution to the Contractor for the value of the first Work performed by the Contractor equal to the
Tenant’s Contribution. Landlord shall not be obligated under the Contract to pay for the value of the first Work performed by the Contractor equal to the Tenant’s Contribution and the Contract shall provide that the Contractor shall look
to the Tenant therefor. 
  
 (c) During the term of the Contract,
Tenant may request Landlord to perform, at Tenant’s sole cost and expense, any special work other than that specified in Construction Documents, as a “Tenant’s Extra”. Should Tenant request Landlord to perform a Tenant’s
Extra, the Landlord may deny such request if Landlord determines that: 
  
 (i) The Tenant’s Extra is not consistent with or better than the existing physical condition of the Building; or 
  
 (ii) The Tenant’s extra will impair the structural integrity of the Building. 
  
 In the event that Tenant requests Landlord to perform a Tenant’s Extra and Landlord does not deny such request as set
forth above, Landlord shall cause the Contractor to submit to Landlord and Tenant a written estimate (the “Estimate”) for the Tenant’s Extra to be performed. Within five business days after submission of the Estimate, Tenant shall in
writing either accept or reject the Estimate. Tenant’s failure to accept or reject the Estimate within said five-day period shall be deemed rejection thereof. In the event the Tenant rejects the Estimate or the Estimate is deemed rejected
Landlord shall not be obligated to construct the Tenant’s Extra. 
  
 Each request by Tenant to Landlord to perform a Tenant’s Extra shall include therewith detailed plans and specification which have been prepared at the sole cost and expense of Tenant. The installation of a Tenant’s Extra shall be
for Tenant’s account; and Tenant shall pay as additional rent hereunder to Landlord therefor an amount equal to Landlord’s actual cost of the Tenant’s Extra, including associated architectural and engineering fees, if any. 

 

 31 

 Upon acceptance of the Estimate, the amount of the Estimate shall be deposited with Landlord; and
thereafter Tenant shall pay to Landlord the cost of the Tenant’s Extra in excess of the Estimate upon being invoiced therefor (but in no event shall such excess be paid later than the satisfactory completion of such Tenant’s Extra). Should
the cost of the Tenant’s Extra be less than the Estimate, Landlord shall promptly refund the difference to Tenant. 
  
 (d) The Tenant represents that the Leased Premises have been examined by Tenant and that the Tenant will accept the Leased Premises in the condition or
state which the Premises is in on this date, without representation or warranty, express or implied, in fact or by law by Landlord and without recourse to Landlord as to the nature, condition or usability thereof. The preceding sentence shall not
apply to Landlord’s Construction. Landlord shall have no liability or obligation concerning the performance by the Contractor. Tenant agrees that Landlord will not be deemed responsible in any manner with respect to the quality or quantity of
the Work or whether the Work has been performed in accordance with the Construction Documents. Tenant agrees that Landlord will not be deemed to have made any representation or warranty, express or implied, in fact or by law concerning the
Contractor or the Work. For the purpose of this paragraph, each Tenant’s Extra shall be deemed a part of the Work and covered by the Contract. 
  
 Tenant’s obligation for the payment of Base Rent and additional Rent, shall not be affected by time in which it takes to complete the Work.

  
 Tenant shall indemnify and save Landlord harmless from and
against, and shall reimburse Landlord for, all liabilities, obligations, damages, fines, penalties, claims, demands, liens (including mechanic’s liens) costs, charges, judgments and expenses, including but not limited to, reasonable
attorneys’ fees which may be imposed upon or incurred or paid by or asserted against Landlord or Landlord’s fee or reversionary or other interest in the Property by reason of or in connection with the execution of the Contract with the
Contractor by the Landlord, the performance of the Work or the performance of a Tenant’s Extra. The indemnity contained in this grammatical paragraph shall not apply to any claim (including a mechanic’s lien claim) imposed against Landlord
or its interest in the Leased Premises resulting from failure of Landlord to meet its obligations under the Contract for the Work unless such failure results from the fact that Landlord has withheld payment to the Contractor because Tenant has
failed to approve the payment. 
  
 Tenant understands that
Landlord will also be causing certain construction to occur at the Leased Premises, which construction (“Landlord’s Construction”) is not part of the Work. The cost of such construction will be paid for by Landlord and Tenant will
have no responsibility for the payment thereof. 
  

 32 

 Landlord and Tenant have executed this Lease the day and year first above written. 
  

					
	LANDLORD:	  	 FCF PROPERTIES, LLC, a Colorado limited
     liability company

			
	 	  	By:	  	 /s/ Andrew Freedman

	 	  	Its:	  	Manager
		
	TENANT:	  	 AMERICAN COIN MERCHANDISING, INC., a
     Delaware corporation

			
	 	  	By:	  	 /s/ W. John Cash

	 	  	Its:	  	Senior Vice President, CFO

  
 ATTEST: 
  

			
	By:	 	 /s/ W. John Cash

	Its	 	(Assistant) Secretary

  

 33 

 STATE OFCOLORADO) 
                                        
         ) SS. 
  
 COUNTY OF BOULDER)

  
 I, Kara Williamson, a Notary Public in and for said County, in
the State aforesaid, do hereby certify that Andrew Freeman, personally known to me to be the Manager of FCF Properties, LLC, a Colorado limited liability company and as such Manager he signed, sealed and delivered the said instrument as his and
voluntary act, for the uses and purposes therein set forth. 
  
 GIVEN under my hand and Notarial Seal this 24 day of October, 2002. 
  

	
	 /s/ Kara Williamson

	 Notary Public

  

 34 

 STATE OF COLORADO) 
  
                                        
         ) SS. 
  
 COUNTY OF BOULDER)

  
 I, Kara Williamson, a Notary public in and for said County, in
the State aforesaid, do hereby certify that W. John Cash, personally known to me to be Senior Vice President and CFO of American Coin Merchandising, Inc., a Delaware corporation, duly licensed to transact business in the State of Colorado, and W.
John Cash, personally known to me to be the Secretary of said corporation and personally known to me to be the persons whose names are subscribed to the foregoing instrument, appeared before me this day in person and severally acknowledged that they
signed and delivered the said instrument as Senior Vice President and CFO and Secretary of said corporation, and caused the Corporate Seal of said corporation to be affixed thereto, pursuant to authority given by the Board of Directors of said
corporation, as their free and voluntary act and as the free and voluntary act and deed of said corporation, for the uses and purposes therein set forth. 
  
 GIVEN under my hand and Notarial Seal this 24 day of October, 2002. 
  

	
	 /s/ Kara Williamson

	 Notary Public

  

 35 

 EXHIBIT A 
 LEGAL DESCRIPTION OF THE LEASED PREMISES 
  
 LOT
13, BLOCK 8, 
 COLORADO TECHNOLOGICAL CENTER, FIRST FILING, 
 COUNTY OF BOULDER, 
 STATE OF COLORADO 
  

 36 

 LEASE AMENDMENT 
  

This lease amendment is made and entered into as of this 6 day of June 2003 by and between FCF PROPERTIES LLC, a Colorado Limited Liability Company
(“Landlord”) and AMERICAN COIN MERCHANDISING, INC., a Delaware Corporation (“Tenant”). 
  
 WITNESSETH 
  
 WHEREAS,
Landlord and Tenant have entered into that certain Industrial Building Lease (the “Lease”) dated October 24, 2002; and 
  
 WHEREAS, Landlord and Tenant wish to modify the Lease as hereinafter set forth, but not otherwise. 
  
 NOW, THEREFORE, in consideration of the mutual promises and agreements herein contained, and for other good and valuable consideration, the
receipt whereof is hereby acknowledged, Landlord and Tenant do hereby agree and the Lease shall be and is hereby modified as follows: 
  

	 	1.	The term “Rent Commencement Date” as the term is used in Article 5, and Section 9.1(b) shall be deleted and the term “Commencement Date” shall be substituted
therefore. 

  

	 	2.	The Commencement Date shall be February 21, 2003. 

  

	 	3.	The figure $706,159 contained in Section 22(b) shall be deleted and the figure $714,809 shall be substituted therefore. 

  
 Except for the modifications contained herein, the Lease shall remain unmodified and in full
force and effect. 
  
 In witness whereof Landlord and Tenant have executed this
Lease Amendment as of the day and year first above written. 
  

					
	 	 	FCF Properties, LLC, a Colorado Limited Liability Company
			
	 	 	By:	 	 /s/ Andrew Freeman

	 	 	 	 	 Its: Manager

	 	 	American Coin Merchandising, Inc., a Delaware Corporation
			
	 	 	By:	 	 /s/ W. John Cash

	 	 	 	 	 W. John Cash

	 	 	 	 	 Senior Vice President, Chief Administrative OfficerPrepared by R.R. Donnelley Financial -- Agreement between Baxter International and Baxter Oncology GmbH

  
 Exhibit 10.6

  
 *CERTAIN INFORMATION IN THIS EXHIBIT HAS BEEN OMITTED AND
FILED 
 SEPARATELY WITH THE COMMISSION. CONFIDENTIAL TREATMENT HAS BEEN 
 REQUESTED WITH RESPECT TO THE OMITTED PORTIONS 
  
 AGREEMENT 
  
 between 
  
 THRESHOLD PHARMACEUTICALS INC.

  
 and 
  
 BAXTER INTERNATIONAL INC. 
  
 and 
  
 BAXTER ONCOLOGY GmbH 
  
 For the Licensing and Development of Glufosfamide 
  

 THIS AGREEMENT is made, as of the date of signature of the last party to affix its signature hereto, 
  
 by and among 
  
 THRESHOLD Pharmaceuticals Inc., a corporation organized and existing under the laws of Delaware of the United States of America and
having its head office at 951 Gateway Boulevard, Suite 3A, South San Francisco, CA 94080, United States of America (hereinafter referred to as “THRESHOLD”), 
  
 and 
  
 Baxter International Inc., a corporation organized and existing under the laws of Delaware of the United States of America and having its headquarters at One
Baxter Parkway, Deerfield, Illinois 60015-4633. United States of America (hereinafter referred to as “BAXTER”) 
  
 and 
  
 Baxter Oncology GmbH, a corporation organized and existing under the laws of the Federal Republic of Germany, having its head office at Daimlerstrasse 40, 60314 Frankfurt, Federal Republic of Germany (hereinafter referred to as
“BAXTER ONCOLOGY”); 
  
 WHEREAS BAXTER and/or BAXTER ONCOLOGY are the
owners of certain proprietary information, patents and know-how related to Glufosfamide, with all right, title and interest thereto; 
  
 WHEREAS BAXTER ONCOLOGY is the licensee of certain patents related to Glufosfamide, owned by BAXTER, with all right, title and interest thereto 
  
 WHEREAS THRESHOLD desires to obtain an exclusive license under the patents and proprietary
information and know-how belonging or licensed to BAXTER and BAXTER ONCOLOGY relating to the composition referred to in the recital above to develop and market a product for human and animal therapeutic uses primarily in tumor diseases. 

 

 2 

 NOW THEREFORE FOR GOOD AND VALUABLE CONSIDERATION, THE RECEIPT AND SUFFICIENCY OF WHICH ARE HEREBY ACKNOWLEDGED, THE
PARTIES INTENDING TO BE LEGALLY BOUND HEREBY, AGREE AS FOLLOWS: 
  

	1.	Definitions 

  
 In this Agreement the following words shall have the following meanings, unless the context otherwise requires: 
  

	 	1.1	“Affiliate” means any firm, person or company which controls, is controlled by or is under common control with a Party where “control” means the
possession, directly or indirectly of the power to direct or cause the direction of the management and policies of such firm, person or company whether through the ownership of voting securities, by contract or otherwise, or the ownership either
directly or indirectly of fifty percent (50%) or more of the voting securities of such firm, person or company (or such smaller maximum ownership interest in those countries where foreign ownership is restricted, but not below forty percent (40%).

  

	 	1.2	“Animal Studies” means those studies approved by THRESHOLD and conducted by BAXTER ONCOLOGY pursuant to Clause 6.2, the results of which provide THRESHOLD
sufficient information upon which to base a decision as to whether to proceed with development of a Licensed Product. 

  

	 	1.3	“BAXTER ONCOLOGY Know-How” means all information in BAXTER ONCOLOGY’s or BAXTER’s possession or under their control at the date of this Agreement or which
comes into their possession or under their control during the term hereof relating to Licensed Product and including, but not limited to, all Manufacturing Know How. 

  

	 	1.4	“BAXTER ONCOLOGY Patents” means all Patents and patent applications set forth in Part A of Schedule 1.4 

  

	 	1.5	“Clinical Trial” means a clinical trial to demonstrate the safety or efficacy of Licensed Product in the Field. 

  

	 	1.6	“Commercial Delivery” means the sale to a Customer of Licensed Product. 

  

	 	1.7	“CSC” means the Commercial Steering Committee which shall be appointed and shall operate in accordance with the provisions of Clause 4. 

  

	 	1.8	“Customer” means any third party, other than an Affiliate or Sub-Licensee of THRESHOLD to whom THRESHOLD or its Affiliates or Sub-Licensee supplies Licensed Product
in a country where such Licensed Product has been approved for sale (including pricing approval where applicable). 

  

	 	1.9	“Development Data” means all data, whether raw or analyzed, charts, studies, summaries, analyses, reports, know-how and other information relating to Licensed
Product generated by or on behalf of THRESHOLD in performing the Development Plan. 

  

	 	1.10	“Development Plan” means the plan directed to the development of Licensed Product to be prepared by THRESHOLD within ninety (90) days of the Effective Date, as
updated and/or modified from time to time by THRESHOLD. 

  

	 	1.11	 “Drug Master File” means the bulk and finished product in final dosage form manufacturing information referenced in a Licensed Product’s
application for marketing approval in the Territory, in such form as is 

  

 3 

	 	 
acceptable to the Regulatory Agency with whom it has been, or is intended to be, filed. 

  

	 	1.12	“DSC” means the Development Steering Committee which shall be appointed and shall operate in accordance with the provisions of Clause 4. 

 

	 	1.13	“Effective Date” means the first business day after satisfaction of the condition set forth in Clause 3.1. 

  

	 	1.14	“FDA” means the Food and Drug Administration of the United States or any successor thereto. 

  

	 	1.15	“Field” means the cure, mitigation, treatment, prevention or diagnosis of (i) cancer in humans and animals, including, but not limited to, benign, pre-malignant,
metastatic and malignant tumors and (ii) such other activities as may be permitted to BAXTER and/or BAXTER ONCOLOGY under their agreement with Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts, a copy of which is attached hereto as
Schedule 1.15 

  

	 	1.16	“Glufosfamide” means ß-D-Glucopyranosyl-N,N ́-di-(2-chloroethyl)-phosphoric acide diamide. 

  

	 	1.17	“Improvement” means any new technique, application, formulation or chemical or biological analog (i.e. metabolite) or derivative developed by or on behalf of a
Party under the Licensed Patents or the Licensed Know-How. For the avoidance of doubt the definition of Improvement excludes Development Data. 

  

	 	1.18	“IND” means an investigational new drug application relating to a Licensed Product filed with the FDA pursuant to 21 C.F.R. Part 312, or such similar application
filed with or submitted to a similar Regulatory Agency in another country, including but not limited to amendments thereto. 

  

	 	1.19	“Indication” means pancreatic cancer. 

  

	 	1.20	“Initiate” means to administer the first dose of Licensed Product to the first patient in a Clinical Trial. 

  

	 	1.21	“Licensed Know How” means the BAXTER ONCOLOGY Know How and the Regulatory Documents. 

  

	 	1.22	“Licensed Patents” means the BAXTER ONCOLOGY Patents and Manufacturing Patents. 

  

	 	1.23	“Licensed Product” means the product known as Glufosfamide together with its salts, solvates, esters, analogs, mimetics, and chemical and biological derivatives.

  

	 	1.24	“Manufacture” means all activities necessary or required to manufacture the Licensed Product in bulk and finished product forms. 

  

	 	1.25	 “Manufacturing and Supply Agreement” means an agreement entered into among the Parties in accordance with Clause 2.2 that pertains to the 

  

 4 

 
manufacture of Licensed Product by BAXTER ONCOLOGY for THRESHOLD. 
  

	 	1.26	“Manufacturing Know How” means all information in BAXTER’s or BAXTER ONCOLOGY’s or their Sub-Contractor’s possession or under their control at the
date of this Agreement or which comes into their possession or under their control during the term hereof relating to the Manufacture of Licensed Product (including but not limited to the identity of any Sub-Contractor). Provided however, that
information in Sub-Contractor’s possession or under their control is only included in “Manufacturing Know-How” to the extent it is or has to be transferred from Sub-Contractor to BAXTER or BAXTER ONCOLOGY. 

  

	 	1.27	“Major Market Countries” means United States of America, France, Germany, Great Britain, Italy and Japan. 

  

	 	1.28	“Manufacturing Patents” means all Patents and Patent applications set forth in Part B of Schedule 1.4. 

  

	 	1.29	“NDA” NDA means a New Drug Application and all supplements filed pursuant to the requirements of the FDA, including all documents, data and other information
concerning Licensed Product which are necessary for, or included in, FDA approval to market Licensed Product in the United States of America as more fully defined in 21. C.F.R. §314.5 et seq or such similar application and supplements filed
with or submitted to a similar Regulatory Agency in another country. 

  

	 	1.30	“Net Sales” means the amount invoiced by THRESHOLD, its Affiliates or Sub-Licensees to Customers for sales of Licensed Product in the Territory less deductions for
the following: (i) cash, trade, quantity and volume credits, allowances, discounts and bad debt (any deduction for bad debt shall be not more than one percent (1%) of sales of Licensed Product, and any allowances for amounts written off as bad debt
shall be included in Net Sales if later paid); (ii) rebates such as price reductions, rebates to social and welfare systems, charge-backs, government mandated rebates and similar rebates; (iii) excise, sales, use, value added, and all other similar
taxes and tariffs and all other similar import/export duties; (iv) invoiced outbound freight and other transportation charges and shipping insurance if any; and (v) allowances or credits for rejections, withdrawals, recalls, and returns. For the
avoidance of doubt, the computation of Net Sales shall not include amounts received by THRESHOLD, its Affiliates or Sub-Licensees for the sale of Licensed Product among THRESHOLD, its Affiliates and Sub-Licensees. 

  

	 	1.31	“New Indication” means any therapeutic indication within the Field, other than the Indication. 

  

	 	1.32	“Parties” means BAXTER, BAXTER ONCOLOGY and THRESHOLD. 

  

	 	1.33	 “Patents” means a patent or patent application and including any and all divisions, continuations, continuations in part, extensions,
substitutions, renewals, registrations, revalidations, re-issues thereof or additions 

  

 5 

	 	 
thereto and including supplementary certificates of protection or similar of or to any patent. 

  

	 	1.34	“Phase I” means, with respect to the United States, the first phase of human clinical trials using a limited number of human subjects to gain evidence of the safety
and tolerability of a product or compound and information regarding pharmacokinetics and potentially pharmacological activity for such product or compound, which human clinical trials are completed prior to the initiation of Phase II, as described
in 21 C.F.R. § 312.21(a), as it may be amended, or, with respect to any other country or jurisdiction, its equivalent in such other country or jurisdiction. 

  

	 	1.35	“Phase II” means, with respect to the United States, the second phase of human clinical trials of a product or compound in human subjects to gain evidence of the
efficacy in one or more indications and expanded evidence of the safety of a product or compound, as well as an indication of the dosage regimen required, as described in 21 C.F.R.§ 312.21(b), as may be amended, or, with respect to any other
country or jurisdiction, its equivalent in such other country or jurisdiction. 

  

	 	1.36	“Phase III” means, with respect to the United States, the third phase of human clinical trials of a product or compound which are large-scale, randomized trials to
gain evidence of the efficacy and safety in a number of human subjects sufficient to support Product Approval for a product or compound with the FDA, as described in 21 C.F.R. § 312.21(c), as it may be amended, or, with respect to any other
country or jurisdiction, its equivalent in such other country or jurisdiction. 

  

	 	1.37	“Product Approval” means the grant of all necessary governmental and regulatory approvals, by the FDA, the EMEA or by any other involved Regulatory Agency to sell
Licensed Product in the Territory. 

  

	 	1.38	“Quarter” means a three (3) month period ending, on the last day of March, June, September or December in any year. 

  

	 	1.39	“Regulatory Agency” means, with respect to any particular country, the governmental authority, body, commission, agency or other instrumentality of such country (or
the EMEA with respect to the EU), with the primary responsibility for the evaluation or approval of pharmaceutical products before a pharmaceutical product can be tested, marketed, promoted, distributed or sold in such country, including such
governmental bodies that have jurisdiction over the pricing and reimbursement of such pharmaceutical product. The term Regulatory Agency includes but is not limited to the FDA. 

  

	 	1.40	 “Regulatory Documents” means, without limitation, all (i) documents, information, data, and reports, regardless of form, filed with, or submitted
to, a Regulatory Agency, (ii) all correspondence to or from a Regulatory Agency, (iii) minutes of all meetings, whether in person or by means of videoconference or teleconference, with a Regulatory Agency or its 

  

 6 

	 	 
representatives, and (iv) all requests, demands, deficiencies, suggestions, reports or other communications by a Regulatory Agency relating to the
development, testing, manufacture, safety, efficacy, or approval of Licensed Product. 

  

	 	1.41	“Royalties” means the amounts due to BAXTER ONCOLOGY in respect of sales of Licensed Products as described in Clause 3.4 herein. 

  

	 	1.42	“Sub-Contractor” means any person, firm or company contracted by BAXTER ONCOLOGY to Manufacture Licensed Product for supply to THRESHOLD. 

 

	 	1.43	“Sub-Licensee” means any person, firm or company licensed by THRESHOLD under a Valid Claim to practice the Licensed Patents. 

  

	 	1.44	“Territory” means all countries of the world. 

  

	 	1.45	“Valid Claim” means a claim in any patent application which has been pending for less than three (3) years from original application or of an issued and unexpired
Patent included in Licensed Patents which has not been disallowed or held unenforceable, unpatentable or invalid by a decision of a court or other governmental agency of competent jurisdiction, unappealable or unappealed within the time allowed for
appeal, and which has not been admitted to be invalid or unenforceable through re-issue or disclaimer or otherwise. 

  

	 	1.46	“Year” means each consecutive calendar year during the term hereof starting from the calendar year that commences after the first Commercial Delivery.

  

	2.	Grant of Licenses 

  

	 	2.1	BAXTER ONCOLOGY and BAXTER hereby grant to THRESHOLD with effect from the Effective Date, subject to the terms and conditions of this Agreement, an exclusive license and/or
sublicense, with the right to sublicense, under and using the Licensed Patents and Licensed Know-How (for itself or on its behalf) to develop, make, have made, use, supply, offer for sale, sell, import, export and otherwise distribute Licensed
Product in the Territory for use in the Field. 

  

	 	2.2	 Notwithstanding the foregoing to the contrary, THRESHOLD shall be entitled to exercise its Clause 2.1 rights in respect of the manufacture of Licensed Products
containing Glufosfamide only as follows. BAXTER’S and BAXTER ONCOLOGY’s existing supply of Glufosfamide shall be used for the Animal Studies and for any Clinical Trials sponsored by THRESHOLD. THRESHOLD, BAXTER, and BAXTER ONCOLOGY further
agree to negotiate diligently and in good faith, from the Effective Date until the date THRESHOLD is required to notify BAXTER ONCOLOGY whether it will proceed with the development of Licensed Product pursuant to Clause 3.2.1, regarding the terms of
a Manufacturing 

  

 7 

	 	 
and Supply Agreement under which BAXTER or BAXTER ONCOLOGY shall be THRESHOLD’s principal supplier of Glufosfamide for commercial use; provided,
however, that: (i) during the term of the Manufacturing and Supply Agreement THRESHOLD shall be free to establish and receive a supply of Licensed Products from a second source, whether that second source be THRESHOLD or a third party; (ii)
THRESHOLD shall have the right, without limitation, in the event of a material breach by BAXTER ONCOLOGY under the Manufacturing and Supply Agreement to manufacture Glufosfamide itself or to contract a Third Party to manufacture Glufosfamide for
THRESHOLD, and (iii) THRESHOLD shall have the right, without limitation, following expiration or termination of, or failure of the Parties to enter into, the Manufacturing and Supply Agreement to manufacture Glufosfamide itself or to contract a
Third Party to manufacture Glufosfamide for THRESHOLD. 

  

	 	2.3	THRESHOLD shall have all right and title to all intellectual property rights, including, but not limited to, patent protection in respect of any Improvements and/or new Licensed
Product. Each Party shall promptly disclose in writing to the other Parties all Improvements and new Licensed Product. 

  

	3.	License Fees, Development Milestone Payments and Royalty Payments 

  

	 	3.1	Upfront Payment 

  
 THRESHOLD shall pay to BAXTER ONCOLOGY the non-refundable sum of one hundred thousand dollars (US$100,000), within fifteen (15) days following the final
signature of this Agreement. 
  

	 	3.2	Development Milestone Payments 

  
 THRESHOLD shall make the following one time payments to BAXTER ONCOLOGY: 
  

	 	3.2.1 	Within [***] days following the receipt of complete final reports for the Animal Studies, THRESHOLD shall notify BAXTER ONCOLOGY whether it will proceed with the development of
Licensed Product. Such notice will be given on or before December 31, 2003; provided that THRESHOLD has had no less than [***] days to review the complete final report. The deadline for such notice shall be extended to the extent necessary to give
THRESHOLD [***] days to make its decision. In the event THRESHOLD decides to proceed with development of a Licensed Product, it shall pay BAXTER ONCOLOGY the sum of one hundred thousand United States dollars (US$100,000) contemporaneously with such
notice, and the data and results of the Animal Studies shall be deemed to be Development Data belonging to THRESHOLD. For the avoidance of doubt such decision triggering the Milestone Payment is the precondition to initiate a Clinical Trial.

  

 8 

	 	3.2.2 	Within [***] days following the Initiation of a Phase III Clinical Trial for the Indication, a sum of one million three hundred thousand United States dollars (US$1,300,000).

  

	 	3.2.3 	Within [***] days of the filing of an application by THRESHOLD to the FDA for Product Approval for use of Licensed Product for the Indication, a sum of [***] United States dollars
(US$[***]). 

  

	 	3.2.4 	Within [***] days of the grant by the FDA of Product Approval for use of Licensed Product for the Indication the sum of [***] United States dollars (US$[***]).

  

	 	3.2.5 	Within [***] days of the grant by the EMEA of Product Approval in the European Union for use of Licensed Product for the Indication the sum of [***] United States dollars
(US$[***]). 

  

	 	3.3	Performance Milestone Payments 

  
 THRESHOLD shall pay to BAXTER ONCOLOGY the following one time amounts: 
  

	 	3.3.1 	At the end of the first calendar quarter following the Year during which the US annual Net Sales exceed US $[***], the sum of [***] United States dollars (US$[***]).

  

	 	3.3.2 	At the end of the first calendar quarter following the Year during which European annual Net Sales exceed US $[***], the sum of [***] United States dollars (US$[***]).

  

	 	3.3.3 	At the end of the first calendar quarter following the Year during which the worldwide annual Net Sales exceed US$[***], the sum of [***] United States dollars (US$[***]); provided
that the sums due to be paid to BAXTER ONCOLOGY pursuant to Clauses 3.3.1 and 3.3.2 have previously become due. 

  

	 	3.4	Royalty Payments 

  

	 	3.4.1 	Subject to the terms and conditions herein, THRESHOLD shall pay to BAXTER ONCOLOGY Royalties as follows: 

  

	 	(a)	An amount equal to [***] of Net Sales of Licensed Product in those countries where, and only for as long as, compound per se patent protection exists for such Licensed Product; and

  

	 	(b)	An amount equal to [***] of Net Sales of Licensed Product in those countries where, and only for as long as, use patent protection covers the use authorized by the applicable
Regulatory Agency for such Licensed Product, but no compound per se patent protection exists in such jurisdictions; and 

  

	 	(c)	An amount equal to [***] of Net Sales of Licensed Product in those countries where no patent protection exists. 

  

 9 

	 	3.4.2 	The Royalties shall be payable on a country by country basis in respect of Net Sales of each Licensed Product made during the longer of: 

  

	 	(a)	the period while there exists a Valid Claim of a Licensed Patent; or 

  

	 	(b)	[***] years from the date of first Commercial Delivery of said Licensed Product in the Territory. 

  

	 	3.5	THRESHOLD shall not be required to pay multiple Royalties hereunder to BAXTER ONCOLOGY due to any Licensed Product being covered by more than one Valid Claim that is included in the
Licensed Patents. Royalties shall be paid at the highest applicable rate set forth in Clause 3.4.1. 

  

	 	3.6	At the end of the period for which any Royalties are due in a given country of the Territory pursuant to this Agreement, THRESHOLD shall have a fully paid, exclusive, royalty free
license, with the right to sublicense, under the Licensed Patents and the Licensed Know How in such country of the Territory. 

  

	 	3.7	Royalties shall be payable within [***] days of the end of each Quarter in respect of sales of Licensed Product made during such Quarter by THRESHOLD and its Sublicensees; provided,
however, that if THRESHOLD has sublicensed its rights under this Agreement but does not have a royalty report from any Sublicensee sufficiently in advance of the due date for Royalty payments for a Quarter, then THRESHOLD shall (i) provide a
good-faith estimate of the Royalties owed on such Sublicensee’s sales for such Quarter, but in any event such estimate shall at least equal the Royalties paid during the preceding Quarter; (ii) pay such estimate; and (iii) make a payment or
take a credit, as appropriate, in subsequent Royalty payments to the extent such estimated Royalties owed differ from actual Royalties owed for such Sublicensee’s sales in such Quarter. Each payment shall be accompanied by a written royalty
statement, certified as accurate by THRESHOLD’s chief financial officer or chief executive officer, setting forth in reasonable detail the amount of Licensed Products sold and the basis of calculation of the Royalties paid during the Quarter to
which the payment pertains. 

  

	 	3.8	 In the event that (i) Licensed Product is deemed by a court of competent jurisdiction to infringe a valid claim of a patent owned or controlled by a third party in
any given country of the Territory, or (ii) THRESHOLD, its Affiliates or its Sub-Licensees determine, at their reasonable discretion, that it is necessary to pay royalties or other fees to any third party to obtain a license to practice any third
party’s rights in order to market or develop a Licensed Product in any given country, then in such event, THRESHOLD and its Affiliates may deduct such royalties due to such third parties (or such amounts expended in settlement of such claim, or
for securing such rights) from the Royalties otherwise due to BAXTER 

  

 10 

	 	 
ONCOLOGY with respect to Net Sales of such Licensed Product in such country. However, the reduction in the royalty rate shall in no case exceed [***].

  

	 	3.9	Should a compulsory license be granted to a third party under the applicable laws of any country under the Licensed Patents or Licensed Know-How licensed hereunder to THRESHOLD, the
Royalty rate payable hereunder for sales of Licensed Products in such country shall be adjusted to match any lower royalty rate granted to such third party for such country, with respect to the sales of such Licensed Products, and during such
periods, for which such third parties sell under the compulsory license articles that compete with the Licensed Products then marketed and sold by THRESHOLD, its Affiliates or Sub-Licensees in that country. In the event that this Clause 3.9 should
come to apply to the adjustment of the royalty rate in any given country, THRESHOLD shall be entitled to the benefit of such reduction. 

  

	 	3.10	The Royalty payable on combination products which include another therapeutic compound in addition to Licensed Product, shall be the applicable Royalty rate set forth in Clause
3.4.1 above based on a pro rata portion of Net Sales of combination products in accordance with the following formula: 

  
 X = A/B, where 
  
 X = the pro rata portion of Net Sales attributable to Licensed Patents and Licensed Know-How licensed hereunder (expressed as a percentage), and

  
 A = the fair market value of the component in the combination
product utilizing the licenses granted hereunder, and 
  
 B = A
plus the fair market value of all other components in the combination product. 
  
 The fair market values described above shall be determined by BAXTER ONCOLOGY and THRESHOLD in good faith. In the absence of agreement as to the fair market value of all of the components contained in a combination
product, the fair market value of each component shall be determined by arbitration in accordance with the provisions hereof. 
  

	 	3.11	 Any amount payable to BAXTER ONCOLOGY in respect of income in a currency other than that of the United States shall be converted into its equivalent in United
States currency at the average selling rate for the relevant foreign currency during the Quarter in which such income has been received by THRESHOLD with such rate to be calculated by averaging the rates as published by The Wall Street
Journal, New York edition, or such other financial newspaper or reporting system agreed upon by THRESHOLD and BAXTER ONCOLOGY, in effect at the close of 

  

 11 

	 	 
business on the business days occurring in the Quarter. If there exist currency translation restrictions, embargoes, or other currency restrictions that
would prevent THRESHOLD, its Affiliates, or Sub-Licensees from converting local currency into United States dollars and remitting the same to BAXTER ONCOLOGY, THRESHOLD, its Affiliates and Sub-Licensees shall be entitled to pay BAXTER ONCOLOGY in
the local currency in the country where such restrictions exist. 

  

	 	3.12	THRESHOLD shall provide an annual report to BAXTER ONCOLOGY, that indicates: (i) amounts of Licensed Products sold during the relevant period; (ii) allowable deductions and (iii)
payments due pursuant to this Agreement. THRESHOLD shall keep and maintain complete and accurate records of sales of Licensed Products. Such records shall be open upon request of BAXTER ONCOLOGY for a special inspection upon not less than seven (7)
days advance written notice not more than once each year, at any reasonable time within two (2) years after the royalty period to which such records relate, by an accounting firm selected by BAXTER ONCOLOGY and reasonably acceptable to THRESHOLD.
THRESHOLD shall permit the representative of such accounting firm to have access during ordinary business hours to such records as may be necessary, to determine the accuracy of Net Sales and any report and/or payment made under this Agreement. Such
representative shall not disclose to BAXTER ONCOLOGY any information other than the quantity, the calculation and Net Sales of Licensed Products sold and shall otherwise maintain such information in confidence. Said findings shall be maintained in
confidence by BAXTER ONCOLOGY. Findings on the accuracy or supposed inaccuracy of such payment shall be disclosed to BAXTER ONCOLOGY by such representative who shall, at the time of reporting his conclusions to BAXTER ONCOLOGY, supply THRESHOLD with
a copy of such findings. If the audit shall determine an underpayment of more than five percent (5%) between royalty reported and that actually due, then the reasonable expense of the audit shall be borne by THRESHOLD and otherwise by BAXTER
ONCOLOGY. 

  

	 	3.13	THRESHOLD shall withhold and pay to the appropriate authorities in respect of any amount due to BAXTER ONCOLOGY hereunder, any and all withholding taxes, duties, fees and other
charges imposed by any taxing authority. In such event, THRESHOLD shall provide BAXTER ONCOLOGY with such evidence of withholding and payment as may be provided by or to taxing authorities. 

  

	 	3.14	Payments due to BAXTER ONCOLOGY pursuant to this Clause 3 not made within 30 (thirty) days after they are due shall bear an interest charge from the due date at the prime rate as
determined by CitiBank, N.A. on the due date, plus 3% (three percent). 

  

 12 

	4.	DSC; Development Plan; CSC 

  

	 	4.1	BAXTER ONCOLOGY and THRESHOLD shall establish the DSC and the CSC which shall exist to facilitate active communication between them during the development and commercialization of
the Licensed Product, it being further agreed and understood that THRESHOLD shall be responsible for and in control of the research and development and commercialization activities of Licensed Product in the Territory. 

  

	 	4.2	As soon as practicable following the date hereof, BAXTER ONCOLOGY and THRESHOLD shall form the DSC which shall consist of [***] representatives from THRESHOLD and [***]
representatives from BAXTER ONCOLOGY. 

  

	 	4.3	THRESHOLD shall prepare and submit a copy of the Development Plan to BAXTER ONCOLOGY’s representatives on the DSC within ninety (90) days of the Execution of this Agreement.
THRESHOLD shall update and/or modify the Development Plan, as well as the budget thereof, on an annual basis. 

  

	 	4.4	The DSC shall meet to discuss the progress of the Development Plan, the attainment of the objectives of each phase of the development and to share any information related to the
development, and commercialization until the formation of the CSC, of the Licensed Product. 

  

	 	4.5	The DSC shall meet at least twice annually and each such meeting shall be held alternately at each of the party’s offices. The DSC shall meet on such other occasions as may be
reasonably requested by either party throughout each stage of the development of the Licensed Product. THRESHOLD and BAXTER ONCOLOGY shall pay their own costs in attending such meetings and may agree to conduct any such meeting by means of
videoconference or teleconference. 

  

	 	4.6	Upon filing of an NDA for the Licensed Product, BAXTER ONCOLOGY and THRESHOLD shall form the CSC which shall consist of [***] representatives from THRESHOLD and [***]
representatives from BAXTER ONCOLOGY. 

  

	 	4.7	The CSC shall meet to discuss the worldwide marketing of Licensed Product, the launch of the Licensed Product in the Territory and the supply forecast of Licensed Product
requirements for sale in the Territory. 

  

	 	4.8	The CSC shall meet on an annual basis. THRESHOLD and BAXTER ONCOLOGY shall pay their own costs in attending such meetings. 

  

	 	4.9	 The activities of the DSC and CSC may be consolidated into one Steering Committee, at any time, upon the mutual agreement of THRESHOLD and BAXTER ONCOLOGY. The DSC
shall cease to exist following approval by the FDA of Licensed Product for marketing and sale; provided, however, the DSC shall continue to function thereafter until any mandatory 

  

 13 

	 	 
post-marketing clinical studies, if any, have been completed and the results thereof analyzed and submitted to the FDA. 

  

	 	4.10	BAXTER ONCOLOGY and THRESHOLD shall establish a written agenda not less than seven (7) days in advance of each meeting of the DSC and the CSC. The hosting Party shall be responsible
for preparing minutes of each meeting of the DSC and the CSC, which shall not become official until submitted and approved by the DSC or CSC, as the case may be. Each of BAXTER ONCOLOGY and THRESHOLD shall be entitled to bring such of its employees
and consultants to meetings of the DSC and the CSC, in addition to its regular members, as it deems appropriate in light of the matters to be discussed. 

  

	5.	THRESHOLD’s Responsibilities 

  

	 	5.1	THRESHOLD shall use its reasonable efforts to undertake the development of the Licensed Product in accordance with the Development Plan and shall diligently perform the work set
forth in the Development Plan using reasonable skill and care and in a manner consistent with accepted practices in the pharmaceutical industry. 

  

	 	5.2	THRESHOLD shall pay the costs of preparing and performing activities related to the Development Plan which are or may be reasonably necessary to develop, apply for and obtain
Product Approvals for Licensed Product in the Field in the Territory, subject to and without derogating from BAXTER ONCOLOGY’s obligations under Section 6 hereinbelow. 

  

	 	5.3	Within [***] of the Execution of the Agreement, THRESHOLD shall Initiate in a country in the Territory a Phase III Clinical Trial of Licensed Product for the Indication, or for
another tumor disease indication, subject to the following conditions: 

  

	 	5.3.1 	THRESHOLD’s receipt from BAXTER ONCOLOGY of the complete chemistry and manufacturing (CMC) file sufficient for regulatory purposes to be incorporated into the IND and NDA
applications to be filed with the FDA for Product Approval or access to the Drug Master Files for Licensed Product prepared by BAXTER ONCOLOGY and/or its Sub-Contractors and on file with the FDA; and 

  

	 	5.3.2 	effectiveness of the IND application with the FDA for use of Licensed Product for the Indication or alternative indication. 

  

	 	5.4	THRESHOLD shall be responsible for preparing and applying for applications for Product Approvals in the Territory and shall be responsible for the maintenance of all Product
Approvals in the Territory and for preparing and applying for applications for, and monitoring all other regulatory approvals relating to Licensed Product. THRESHOLD shall be responsible for deciding in which countries in the Territory such
activities shall be conducted. 

  

 14 

	 	5.5	All Product Approvals applied for pursuant to Clause 5.4 shall be applied for in the name of THRESHOLD or its Affiliates, contractors or Sub-Licensees. 

  

	 	5.6	THRESHOLD shall use reasonable efforts consistent with its normal business practices to promote and market the Licensed Product in the Major Market Countries in the Territory.
Subject to restrictions imposed by applicable law or regulation, if any, upon request of BAXTER ONCOLOGY, THRESHOLD shall mark Licensed Product or promotional materials/accompanying literature to indicate that the Licensed Patents are licensed from
BAXTER. 

  

	 	5.7	THRESHOLD, its Affiliates or Sub-Licensees, as the case may be, shall be responsible for the preparation of scientific literature and promotional material relating to Licensed
Product and its activities in the Territory in accordance with its normal business practices and quality standards and in accordance with local legal requirements. A draft copy of any such scientific and/or promotional material shall be given to
BAXTER ONCOLOGY no less than ten (10) days prior to the distribution thereof for BAXTER ONCOLOGY’s approval, which will not be unreasonably, withheld or delayed, unless THRESHOLD is required by law to release such information, in which case it
will be exempt from giving BAXTER ONCOLOGY a copy in advance. THRESHOLD will provide BAXTER ONCOLOGY with three (3) final copies of any such materials. 

  

	6.	BAXTER ONCOLOGY’s Responsibilities 

  

	 	6.1	Within thirty (30) days after the Effective Date, BAXTER ONCOLOGY shall provide THRESHOLD with all documentary form or other form of licensed Know How, research and development,
clinical and manufacturing data, and Regulatory Documents related to the Licensed Product including, but not limited to, all data resulting from Phase I and Phase II clinical trials of Licensed Product, for the Indication or alternative indications,
conducted by or on behalf of BAXTER or BAXTER ONCOLOGY. As further information and/or data related to Licensed Product comes into possession of BAXTER ONCOLOGY it shall forthwith disclose the same to THRESHOLD. 

  
 Following execution of this Agreement, BAXTER ONCOLOGY shall provide
THRESHOLD access for copying to all written BAXTER ONCOLOGY Know-How, evaluations, memorandum and documentation in its possession relevant to the Licensed Product. BAXTER ONCOLOGY shall use reasonable efforts to provide its personnel time for
preparation and transfer of technology (including, but not limited to, manufacturing technology specific to Licensed Product) and BAXTER ONCOLOGY Know-How in BAXTER ONCOLOGY’s possession, relating to Licensed Product that is necessary for the
development and manufacture of Licensed Product by THRESHOLD or a THRESHOLD Sub-licensee or Subcontractor. Such information shall be specific to Licensed Product and 

  

 15 

 
BAXTER ONCOLOGY shall be under no obligation to transfer general knowledge of development, manufacture, registration or commercialization of this type of
product. 
  
 BAXTER ONCOLOGY’s obligations in accordance
with Clause 6.1 shall include, but not be limited to, making employees available for telephone consultations with respect to the transfer of written information and associated documentation relating to pre-clinical and clinical activities, IND, NDA
and Manufacture matters. 
  

	 	6.2	BAXTER ONCOLOGY will conduct animal studies to determine dose titration of the combination of Glufosfamide and gemcitabine and one xenograft study with human pancreatic cancer
tissue using this combination with changing treatment sequences (Glufosfamide and gemcitabine simultaneously, Glufosfamide then gemcitabine, or gemcitabine first). BAXTER may conduct additional animal studies with other xenograft types as well as a
combination study of Glufosfamide with 5-FU. BAXTER will complete such studies and report the results therefrom to THRESHOLD no later than 15 November 2003. During the conduct of the foregoing studies, BAXTER shall keep THRESHOLD informed of the
status of such studies and the results thereof on an ongoing basis. 

  

	 	6.3	BAXTER and BAXTER ONCOLOGY shall be responsible for the filing, prosecution and maintenance, at their expense, of all Licensed Patents. 

  

	7.	Patents 

  

	 	7.1	THRESHOLD may, at its own cost and expense, prepare, file and prosecute new patent applications for the Licensed Product and uses or methods thereof, as it sees fit. Notwithstanding
the foregoing, should BAXTER and BAXTER ONCOLOGY decide that they are no longer interested in maintaining or prosecuting a Licensed Patent, BAXTER and BAXTER ONCOLOGY shall assign free of charge such Licensed Patent to THRESHOLD. Upon assignment,
such Licensed Patent shall no longer be included in Licensed Patents and THRESHOLD may thereafter maintain and prosecute such Licensed Patent at its expense to the extent that it desires to do so. 

  

	 	7.2	Infringement of Third Party Rights 

  

	 	7.2.1 	If the manufacture, use or sale of the Licensed Products using the Licensed Patents and Licensed Know How may constitute an infringement of the rights of a third party in the
Territory, each Party shall, as soon as it becomes aware of such possible infringement, notify the other Parties thereof in writing. 

  

	 	7.2.2 	 The Parties shall after receipt of such notice referred to in Clause 7.2.1 above, discuss the situation and, to the extent necessary, attempt to agree on a course
of action in order to 

  

 16 

	 	 
permit THRESHOLD to practice the licenses granted under this Agreement. Such course of action may include (1) obtaining an appropriate license from such
third party or (2) contesting any claim or proceedings brought by the third party. 

  

	 	7.2.3 	If within [***] the Parties fail to agree upon a course of action, BAXTER ONCOLOGY or BAXTER may decide upon the course of action at its expense in the interest of further
development and/or commercialization of Licensed Product, including the negotiation of an appropriate license from such third party, in which event BAXTER ONCOLOGY or BAXTER shall keep THRESHOLD fully informed as to progress of such negotiations or
the defense of any suit or claim and shall seek and consider the opinion of THRESHOLD regarding all such matters. 

  

	 	7.2.4 	BAXTER ONCOLOGY or BAXTER shall make no settlement of any claims of a third party without the written consent of THRESHOLD, which consent shall not be unreasonably withheld or
delayed. 

  

	 	7.2.5 	In the event of a final judgment or settlement in any suit brought by a third party or settlement of a claim of a third party against THRESHOLD requiring royalty payments for any
other damages to be paid by THRESHOLD, such royalty payments or damages paid by THRESHOLD shall be deducted from Royalties required to be paid to BAXTER. 

  

	 	7.3	Infringement of Licensed Patents and Licensed Know-How 

  

	 	7.3.1 	In the event that either party becomes aware of any infringement or suspected infringement of the Licensed Patents or misuse of Licensed Know-How or Development Data, then it shall
promptly give notice to the other in writing and: 

  

	 	7.3.2 	BAXTER ONCOLOGY and THRESHOLD shall consult within [***] days after one Party gives notice to the other Party of any infringement or suspected infringement to decide what steps
shall be taken to prevent or terminate such infringement or misuse and the proportions in which they shall share the cost thereof and any damages and other sums which may be awarded in their favour or against them. 

  

	 	7.3.3 	 When failing agreement between BAXTER ONCOLOGY and THRESHOLD by the end of the period set forth in Clause 7.3.2, unless such period has been extended by mutual
written agreement of BAXTER ONCOLOGY and THRESHOLD, then THRESHOLD may at its own discretion take such action that it may consider necessary and appropriate to terminate or prevent such infringement or misuse and THRESHOLD shall be entitled, subject
to all damages and other sums which may be awarded 

  

 17 

	 	 
or recovered against it as a result thereof, to all damages and other sums recovered by it and shall indemnify BAXTER and BAXTER ONCOLOGY against all and any
costs, expenses, losses, damages or compensation awarded against or incurred by BAXTER and BAXTER ONCOLOGY as a result of such action being taken. 

  

	 	7.3.4 	THRESHOLD shall not make any settlement or compromise without the consent of BAXTER ONCOLOGY, which consent shall not be unreasonably withheld or delayed. If any such settlement
includes the grant of a license on terms more favorable than those provided to THRESHOLD hereunder, the terms of THRESHOLD’s license shall be automatically modified to embody such more favorable terms for the benefit of THRESHOLD.

  

	 	7.3.5 	If THRESHOLD determines not to institute action to restrain infringement or suspected infringement within [***] after failing agreement by the Parties and notice from BAXTER
ONCOLOGY, BAXTER ONCOLOGY shall have the right to institute action at its own expense and on the same terms and conditions as set forth in Clauses 7.3.3 and 7.3.4, with BAXTER ONCOLOGY assuming the rights and duties of THRESHOLD, and THRESHOLD
assuming the rights and duties of BAXTER ONCOLOGY, under Clauses 7.3.3 and 7.3.4. 

  

	 	7.3.6 	Each Party shall provide all reasonable assistance to the other (including but not limited to the use of its name in or being joined as a party to the proceedings) at the request of
the other, in connection with any action to be taken by the other party pursuant to the provisions of this Clause 7. 

  

	 	7.4	Patent Protection Extensions 

  
 Each Party agrees to cooperate with the other Parties to secure, where possible, appropriate patent protection extensions and shall inform the other
Parties in writing within twenty (20) days after: 
  

	 	7.4.1 	the initiation of each Phase of clinical trials of a Licensed Product; 

  

	 	7.4.2 	the date of filing of an NDA for a Licensed Product in the United States or its foreign equivalent in a Major Market Country; 

  

	 	7.4.3 	the date of obtaining approval of an NDA for a Licensed Product in the United States or its foreign equivalent in a Major Market Country; 

  

	 	7.4.4 	the date of the first sale of a Licensed Product in each country of the Territory; and 

  

 18 

	 	7.4.5 	any events that might be material in connection with a possible extension of the patent protection term. 

  

	 	7.4.6 	In this regard, the Parties shall cooperate in filing for and obtaining patent protection extensions and supplementary or complementary protection certificates in any country of the
Territory, if and when available, including supplementary protection certificates in European Union (“EU”) countries and European Free Trade Area (“EFTA”) countries, patent extensions in the United States, and administrative
protection, such as so-called pipeline protection in certain countries of the Territory. Such cooperation shall include, without limitation, providing any information, data and documents in a timely manner for the purpose of applying for patent
extension and, within one (1) month of receipt, a copy of every marketing authorization for Licensed Product issued by any country providing for patent protection extensions, and in addition, within one (1) month of availability of the document, a
copy of the official journal page from each EU or EFTA country giving the marketing approval number and date of authorization for Licensed Product, and a summary of the characteristics of Licensed Product for that country, for the purpose of
applying for supplementary protection certificates under EEC (European Economic Community) Directive 1768/92, and providing information and signing of documents as required. 

  

	8.	Warranty, Liability and Indemnity 

  

	 	8.1	Warranties 

  
 BAXTER ONCOLOGY and BAXTER warrant that: 
  

	 	8.1.1 	they are free to enter into this Agreement in their own right and that there are no rights exercisable by or obligations owed to any third party which may prevent or restrict them
from entering into this Agreement and that the execution and delivery of this Agreement and performance hereunder by them has been duly authorized by all necessary corporate action; 

  

	 	8.1.2 	the Licensed Patents and the Licensed Know-How comprise all of the intellectual property owned or controlled by BAXTER and BAXTER ONCOLOGY related to Licensed Products;

  

	 	8.1.3 	BAXTER ONCOLOGY has disclosed or will disclose according to Clause 6 to THRESHOLD all Licensed Know-How under its or its licensor’s control or in its or licensor’s
possession and it has not disclosed to any third party other than under written obligation of confidence and non-use the Licensed Patents or Licensed Know-How or the subject matter thereof; 

  

 19 

	 	8.1.4 	so far as they are aware having made due and proper enquiry and subject to the filing of a certificate disclaiming Glufosfamide from the scope of the claims of US Patent No.
6489302, the Licensed Patents are or will be when granted valid and that the manufacture use, supply, sale, import or export of Licensed Product for the Field or for any other indication will not infringe the rights of any third party in the
Territory, and in addition to any other right or remedy that THRESHOLD may have under this Agreement or law, THRESHOLD shall have the right to terminate this Agreement in the event that a certificate of correction disclaiming Glufosfamide from the
scope of the claims of US Patent No. 6489302 assigned to the Deutsches Krebsforschungszentrum Stiftung des Offentlichen Rechts, 69120 Heidelberg, DE, has not been filed with the US Patent Office by the patent owner on or before November 30, 2003
and, in the event of such termination, BAXTER ONCOLOGY shall pay THRESHOLD the sum of [***] U.S. dollars ($[***]) as a termination fee and as liquidated damages for such termination; the Parties agree to take any steps, if and as far as necessary,
with regard to the above patent family in close cooperation; 

  

	 	8.1.5 	so far as they are aware having made due and proper enquiry, there is no know-how or other information owned or controlled by BAXTER, BAXTER ONCOLOGY, their licensor or their
Sub-Contractors necessary for the development, use, manufacture, supply or sale of Licensed Products other than the Licensed Know How, and that BAXTER is the absolute beneficial and legal owner of the Licensed Patents which comprise all the
intellectual property possessed or controlled by them relating to the Licensed Product, its uses, and manufacture, and BAXTER and BAXTER ONCOLOGY are the beneficial and legal owners of the Licensed Know-How, both the Licensed Patents and the
Licensed Know-How are free and clear of all liens, charges and encumbrances, and they are entitled to grant all of the rights granted or agreed to be granted hereunder; 

  

	 	8.1.6 	they have not granted and will not grant to any person or entity, other than THRESHOLD, any right, license or privilege with respect to the Licensed Patents and Licensed Know How
for use in the Territory; 

  

	 	8.1.7 	BAXTER and BAXTER ONCOLOGY have disclosed to THRESHOLD all information in their possession relating to the Licensed Product and in which the novelty, validity or sufficiency of the
Licensed Patents and any claim made therein has been challenged or disallowed; 

  

	 	8.1.8 	 they know of no information or data which will or may adversely affect or prevent the development, manufacture or use of 

  

 20 

	 	 
Licensed Product in the Field in the Territory or render the use of Licensed Product for use by way of administration to humans unsafe or lacking in
efficacy; and 

  

	 	8.1.9 	none of BAXTER, BAXTER ONCOLOGY or their Affiliates, Sublicensees or Sub-Contractors shall utilize the Licensed Patents or Licensed Know How, or develop Glufosfamide for use in the
Territory. 

  

	 	8.2	Product Liability 

  

	 	8.2.1 	THRESHOLD shall assume all third party liabilities arising from the, use, offer for sale or supply, sale or supply by through or on behalf of THRESHOLD or its Affiliates or
Sub-Licensees of Licensed Products (and related materials) including without limitation all claims based upon product liability laws, except for liabilities and claims arising from the breach of the terms of the Agreement by BAXTER ONCOLOGY or the
negligence of BAXTER ONCOLOGY or its Affiliates for which BAXTER ONCOLOGY and BAXTER shall assume all liabilities. To the extent claims based upon product liability laws arise from instructions or specifications of THRESHOLD for the Manufacture of
Licensed Products that are not based on instructions or specifications provided by BAXTER or BAXTER ONCOLOGY, THRESHOLD shall assume all related liabilities. 

  

	 	8.2.2 	THRESHOLD shall defend, indemnify and hold harmless BAXTER, BAXTER ONCOLOGY, their Sub-Contractor(s), their Affiliates, their directors, officers, employees and consultants and
those of their Affiliates and Sub-Contractor(s) from and against any and all claims, demands, losses, damages and/or expenses (including without limitation reasonable legal fees) arising from or in connection with any use by, sale to third parties
or supply of third parties by THRESHOLD or its Affiliates or Sub-Licensees of Licensed Products in the Territory except to the extent that any such claims, demands, losses, damages and/or expenses result from the negligence of BAXTER, BAXTER
ONCOLOGY or its Affiliates or the breach by BAXTER ONCOLOGY of the terms of this Agreement. To the extent third party claims arise from instructions or specifications of THRESHOLD for the Manufacture of Licensed Products that are not based on
instructions or specifications provided by BAXTER or BAXTER ONCOLOGY, THRESHOLD shall defend, indemnify and hold harmless BAXTER, BAXTER ONCOLOGY, their Sub-Contractor(s), their Affiliates, their directors, officers, employees and consultants and
those of their Affiliates and Sub-Contractor(s) from and against any and all such claims. 

  

 21 

	 	8.2.3 	BAXTER ONCOLOGY and BAXTER shall defend, indemnify and hold harmless THRESHOLD, its Affiliates, its Sub-Licensees, its directors, officers, employees and consultants and those of
its Affiliates and Sub-Licensees from and against any and all claims, demands, losses, damages and/or expenses (including without limitation reasonable legal fees) arising from any use by, sale to or supply by THRESHOLD or its Affiliates or
Sub-Licensees of Licensed Products in the Territory to the extent that any such claims, demands, losses, damages and/or expenses result from the negligence of BAXTER ONCOLOGY or its Affiliates or the breach by BAXTER ONCOLOGY or BAXTER of the terms
of this Agreement. 

  

	 	8.2.4 	Within thirty (30) days of receipt of written request for indemnification, to be provided promptly upon receipt of a claim, the party from whom indemnification is sought shall
advise the other whether it will provide the requested indemnification. The indemnified party shall permit the indemnifying party, at the indemnifying party’s expense, to assume the complete defense of any claims with a full authority to
conduct such defense and to settle or otherwise dispose of the claims as provided below. The indemnified party will fully co-operate in such defense and shall provide reasonable assistance necessary to enable the indemnifying party to defend such
claims. The indemnified party may retain separate co-counsel, at its sole cost and expense and participate in the defense of the claim. The indemnifying party will not, except with the consent of the indemnified party, consent to the entry of any
judgment or enter into any settlement which provides for any relief other than the payment of monetary damage and which does not include as an unconditional term thereof the giving by the claimant or plaintiff to the indemnified party a release from
all liability in respect thereof. The indemnifying party shall not be responsible for or bound by any settlement made by the indemnified party without the prior written consent of the indemnifying party, which consent shall not be unreasonably
withheld or denied. To the extent that any claim for indemnification involves an action wherein counts or claims are alleged which are attributed or attributable to the indemnified party, following settlement or termination of said action, the
Parties agree to apportion their respective indemnification obligations based upon their attributed fault in the event of jury, court or other alternate dispute resolution mechanism or based upon good faith negotiations among the Parties in the
event of a settlement. 

  

	 	8.2.5 	 THRESHOLD and BAXTER ONCOLOGY shall each use its reasonable efforts to obtain and maintain in force at all times during the term hereof third party liability
insurance in respect of 

  

 22 

	 	 
the risks in respect of which it is providing indemnity hereunder with a reputable insurance carrier or by self-insurance. THRESHOLD and BAXTER ONCOLOGY
shall each use its reasonable endeavors to name the other as named insured under its policy of insurance as aforesaid and provide a copy thereof upon request. 

  

	9.	BAXTER ONCOLOGY Improvements 

  

	 	9.1	BAXTER ONCOLOGY and BAXTER shall promptly disclose in writing to THRESHOLD, free of charge all new techniques, formulations, applications or chemical or biological analogs (i.e.
metabolites), or derivatives of Licensed Product developed or acquired by BAXTER ONCOLOGY or BAXTER (“BAXTER ONCOLOGY Improvements”). 

  

	 	9.2	Where THRESHOLD wishes to use a BAXTER ONCOLOGY Improvement for Licensed Products it shall notify BAXTER ONCOLOGY or BAXTER, as the case may be, of its wish within 90 (ninety) days
of being informed thereof and shall have the right to receive an exclusive, royalty-free license to use BAXTER ONCOLOGY Improvements developed or acquired by BAXTER ONCOLOGY in the Territory in respect of Licensed Products in the Field in accordance
with the provisions of this Agreement, together with the right to grant sub-licenses thereunder in accordance with the terms hereof; 

  

	10.	Confidentiality 

  

	 	10.1	BAXTER, BAXTER ONCOLOGY and THRESHOLD undertake to each other to keep, and shall procure that their respective Affiliates, Sub-Licensees, employees, directors, officers, consultants
and contractors (including those of any Affiliate) shall keep, confidential all information marked “confidential” received from each other during or in anticipation of – but after the effective date of the confidentiality agreement
between the parties dated October 4, 2002 – this Agreement however obtained and in whatever form (the “Confidential Information”) provided that Confidential Information shall not include the following: 

  

	 	10.1.1	 information which at the time of disclosure by one party to the other is in the public domain; 

  

	 	10.1.2	 information which after disclosure by one party to the other becomes part of the public domain by publication except by breach of this Agreement; 

  

	 	10.1.3	 information which the receiving party can establish by competent proof was already in its possession at the time of its receipt and was not acquired directly or indirectly
from the other party; or 

  

	 	10.1.4	 information received from third parties who were lawfully entitled to disclose such information. 

  

 23 

	 	10.2	Any Confidential Information received from the other party shall not be disclosed or used for any purpose other than as provided or anticipated under this Agreement.

  

	 	10.3	The confidentiality and non-use obligations contained in this Agreement shall continue for the duration of this Agreement and for a period of ten (10) years after termination or
expiry of this Agreement. 

  

	 	10.4	The provisions of this Clause 10 shall in no event prevent THRESHOLD from disclosing any Licensed Know How to regulatory authorities or other governmental agencies in support of any
application to conduct Clinical Trials or for regulatory approvals or any amendments thereof for Licensed Products in accordance with the provisions of this Agreement, or to prospective investors or to prospective sub-licensees who are bound by an
obligation of confidentiality, or in general whenever required to disclose such information under any applicable law or regulation. 

  

	 	10.4.1	 Where one party intends to make any public release of scientific data or other information relating to Licensed Products it shall give the other party thirty (30) days prior
notice thereof together with the text of any such release. Prior to making any such release, the party intending the release shall modify the context thereof to take account of any reasonable comments made by the other party. Notwithstanding the
foregoing, BAXTER ONCOLOGY shall not make any such release where in the reasonable opinion of THRESHOLD to do so would adversely affect the development of Licensed Product, its commercial value or any intellectual property (including Development
Data relating thereto). 

  

	11.	Termination 

  

	 	11.1	Termination by Either Party 

  
 Either Party may terminate this Agreement forthwith by notice in writing given at any time if the other party is in material breach of any of its
obligations hereunder except in the case of a material breach capable of remedy within sixty (60) days, where the material breach has been remedied within such sixty (60) days of the defaulting party receiving notice specifying the material breach
and requiring its remedy. Notwithstanding the foregoing, Clause 11.2, and not this Clause 11.1, shall govern terminations under the circumstances described therein. 
  
 A material breach of this Agreement is (1) a willful act or omission by the party in breach that would deprive the other
party of a major part of the value of what it had contracted for and for which damages are not an adequate remedy; or (2) the non-payment of money within thirty (30) days of the date upon which it is due and payable hereunder. 
  

 24 

	 	11.2	BAXTER ONCOLOGY shall in addition have the right to terminate this Agreement: 

  

	 	11.2.1	 If THRESHOLD materially breaches its obligation to perform its obligations as set forth in Clause 5 and such breach remains uncured for a period of ninety (90) days after the
delivery of notice of such breach to THRESHOLD; 

  

	 	11.2.2	 THRESHOLD discontinues its development and commercialization activities for a continuous period of twelve (12) months in a manner that is inconsistent with the then current
Development Plan, and such breach remains uncured for a period of ninety (90) days after the delivery of notice of such breach to THRESHOLD; 

  

	 	11.2.3	 Forthwith by notice in writing given at any time if an order is made or a resolution is passed for the winding up or insolvency of THRESHOLD (other than voluntarily for the
purposes of solvent amalgamation or reconstruction) or an order is made for the appointment of an administrator to manage the other party’s affairs, business and property or if a receiver (which expression shall include an administrative
receiver) is appointed of any of THRESHOLD’s assets or undertaking or if circumstances arise which entitle the court or a creditor to appoint a receiver or manager or which entitle the court to make a winding-up order or if a voluntary
arrangement is proposed in respect of THRESHOLD or if THRESHOLD takes or suffers any similar or analogous action in consequence of debt, unless any such action is withdrawn or set aside within 60 (sixty) days. The licenses granted pursuant to this
Agreement shall be deemed to be licenses of “Intellectual Property” for purposes of Section 365(n) of the U.S. Bankruptcy Code. 

  

	 	11.3	THRESHOLD shall have the right to terminate this Agreement, (and the underlying licenses) by notice in writing given at any time upon 60 (sixty) days notice to BAXTER ONCOLOGY with
or without cause. 

  

	12.	Consequences Of Termination 

  

	 	12.1	Upon termination of this Agreement by BAXTER ONCOLOGY or, without cause, by THRESHOLD: 

  

	 	12.1.1	 Licenses Terminated 

  
 Subject to other provisions of this Clause the licenses granted under Clause 2 shall terminate automatically and THRESHOLD shall procure that its
Affiliates and Sub-Licensees shall immediately stop all activities licensed hereunder except that (i) any Sub-licensee of THRESHOLD that is not in default of its obligations under its sub-license shall be entitled to continue its sub-license in full
force and effect subject to the provisions of this Agreement to the benefit of BAXTER and BAXTER ONCOLOGY, and (ii) THRESHOLD, its Affiliates and 

  

 25 

 
Sub-Licensees shall be permitted to offer for sale and sell and supply remaining stocks of Licensed Products in their possession at the date of termination
or delivered thereafter as quickly as reasonably possible and complete deliveries on contracts in force at that date subject to the payment of license fees, milestone payments and royalties under and in accordance with the provisions of Clause 3.

  

	 	12.1.2	 Payment Due 

  
 THRESHOLD shall make all outstanding license fees, milestone and Royalty payments due hereunder to BAXTER ONCOLOGY. 
  

	 	12.1.3	 Continuing Provisions 

  
 The following provisions of this Agreement shall continue in full force and effect following termination: this Clause 12 and Clauses 1, 7.2 (but only for
pre-termination infringement), 7.3 (but only for pre-termination infringement), 8, 10, 14 and 15. Termination of this Agreement for any reason does not relieve the Parties of any obligation accruing prior to the effective date of the termination,
including the obligation to make the payments set forth in Clause 3. 
  

	 	12.1.4	 Return of Know-How 

  
 Subject to the other provisions of this Clause 12, THRESHOLD shall return to BAXTER ONCOLOGY all Licensed Know-How and documents given to THRESHOLD by
BAXTER ONCOLOGY pursuant to this Agreement in its possession or the possession of its Affiliates. 
  

	 	12.1.5	 Use of Development Data 

  
 Subject to the other provisions of this Clause 12, THRESHOLD grants to BAXTER ONCOLOGY the right to use Development Data (where it is free to do so) and
transfer to BAXTER ONCOLOGY or its designee(s) all Product Approvals in its name. 
  

	 	12.1.6	 Third Party Agreements 

  
 BAXTER ONCOLOGY or BAXTER agrees to recognize THRESHOLD’s Sub-Licensees as its direct licensees following a termination of this Agreement by BAXTER
ONCOLOGY provided that (i) such Sub-Licensees are in compliance with the terms of their sublicenses, (ii) BAXTER or BAXTER ONCOLOGY would not be required to undertake obligations in excess of those undertaken pursuant to this Agreement, and (iii)
such Sub-Licensees agree with having BAXTER or BAXTER ONCOLOGY as direct Licensor. Notwithstanding the foregoing to the contrary and as an alternative thereto, BAXTER 

  

 26 

 
ONCOLOGY shall use reasonable efforts consistent with the terms of this Agreement as reasonable under the circumstances to assist THRESHOLD, at
THRESHOLD’s request, in discharging THRESHOLD ́s obligations in full under all agreements between THRESHOLD and its Sub-Licensees or other third parties until each can be terminated by THRESHOLD in accordance with its terms and without
liability to THRESHOLD. 
  

	 	12.2	Rights and Remedies for Breach 

  
 Any rights or remedies of either party arising from any breach shall continue to be enforceable unless previously waived in writing, including without
limitation either Party’s rights to recover damages for breach of this Agreement by the other Party. 
  

	13.	Force Majeure 

  

	 	13.1	Neither party shall terminate this Agreement or be liable to the other under this Agreement for loss or damages attributable to any act of God, earthquake, flood, fire, explosion,
strike, lockout, labor dispute, casualty or accident, war, revolution, civil commotion, terrorism, act of public enemies, blockage or embargo, injunction, law, order, proclamation, regulation, ordinance, demand or requirement of any government or
subdivision, authority (including, without limitation, regulatory authorities) or representatives of any such government, or any other cause beyond the reasonable control of such party, if the party affected shall give prompt notice of any such
cause to the other party. The party giving such notice shall thereupon be excused from such of its obligations hereunder for so long as it is so disabled during, but no longer than the existence of such cause. 

  

	 	13.2	If such cause continues unabated for a period of at least 90 (ninety) days, the Parties will meet to discuss what, if any, modifications should be made to this Agreement as a
consequence of such Force Majeure. 

  

	14.	Miscellaneous 

  

	 	14.1	Performance by Affiliates, Sub-Licensees and Sub-Contractors 

  
 The Parties may perform some or all of their obligations under this Agreement through their Affiliates, Sub-Licensees or Sub-Contractors and third parties
provided that each party shall remain solely responsible for and be guarantor of the performance by its Affiliates, Sub-Licensees or Sub-Contractors and third parties and procure that its Affiliates, Sub-Licensees or Sub-Contractors and such third
parties comply fully with the provision of this Agreement in connection with such performance. 
  

 27 

	 	14.2	Severance 

  
 If any provision of this Agreement is held to be invalid or inapplicable by a court of competent jurisdiction the remaining provisions will continue in
full force and the Parties will make such amendments to this Agreement by the addition or deletion of wording as appropriate to remove the invalid or unenforceable part of such provision but otherwise achieve, to the maximum extent permissible, the
economic, legal and commercial objectives of the original provision. 
  

	 	14.3	Waiver 

  
 Failure or delay by either party in exercising or enforcing any right or remedy under this Agreement in whole or in part shall not be deemed a waiver
thereof or prevent the subsequent exercise of that or any other rights or remedy. 
  

	 	14.4	Interpretation 

  
 The headings in this Agreement are for convenience only and shall not affect its interpretation. References to the singular include the plural and vice
versa. References to persons include companies, partnerships and all other forms of body corporate or unincorporated and references to recitals, clauses and schedules are references to Recitals, Clauses or Schedules to this Agreement. 
  

	 	14.5	Language 

  
 All documents delivered under this Agreement by BAXTER or BAXTER ONCOLOGY to THRESHOLD, if maintained or prepared in other than the English language,
shall be accompanied by English translations thereof. All communications between the parties shall be in English. 
  

	 	14.6	Assignment 

  

	 	14.6.1	 Subject to Clauses 14.6.2, 14.6.3 and 14.6.4 neither BAXTER, BAXTER ONCOLOGY nor THRESHOLD shall assign, transfer, sub-license, sub-contract, mortgage, charge or otherwise
make over to any third party any of its rights or obligations under this Agreement or the Licensed Patents or BAXTER ONCOLOGY Know-How without the prior written consent of the other party, except to an Affiliate or a party acquiring all or
substantially all of the business of the assigning Party to which this Agreement relates or to a party merging with one of the Parties. Prior to any such permitted assignment the Party wishing to effect the transaction shall use reasonable efforts
to procure that the third party concerned covenants directly with the other Party to this Agreement to comply with all the provisions of this Agreement, which shall be binding on it as the successor and assign of such Party.

  

 28 

	 	14.6.2	 THRESHOLD may grant any sub-license or sub-contract of its rights or obligations hereunder without the prior written consent of BAXTER or BAXTER ONCOLOGY and shall notify
BAXTER ONCOLOGY of the grant of any sub-contract or sub-license and provide BAXTER ONCOLOGY with a redacted summary of the terms thereof as soon as reasonably practicable following such grant. Subject to receipt of a confidentiality undertaking
THRESHOLD shall grant to an independent accountant (acceptable to BAXTER ONCOLOGY) a right to inspect such agreements for the purpose of verifying the calculation of sums to be paid by THRESHOLD to BAXTER ONCOLOGY hereunder. The grant of any
sub-license by THRESHOLD shall not relieve THRESHOLD of any of its obligations hereunder and THRESHOLD shall incorporate within the terms of any such agreement rights and obligations consistent with the rights and obligations granted hereunder and
including without limitation those as to confidentiality and THRESHOLD shall procure the performance of any sub-license by its Sub-Licensee. Where royalties are payable by any Sub-Licensee, THRESHOLD shall account for royalties on sales and supply
of Licensed Products by Sub-Licensees of THRESHOLD in the same manner and upon the same terms as set forth herein and procure for BAXTER ONCOLOGY rights and access to facilities for verifying such royalties. Where THRESHOLD grants any sub-license
the term THRESHOLD used in this license shall be deemed to include a reference to Sub-Licensees of THRESHOLD. 

  

	 	14.6.3	 Without derogating from any of THRESHOLD’s rights hereunder, in any event that BAXTER ONCOLOGY sub-contracts the Manufacture of Licensed Product, other than to THRESHOLD,
it shall not be relieved of its obligations hereunder and BAXTER ONCOLOGY shall procure the performance by its Sub-Contractor of any such agreement and any reference to BAXTER ONCOLOGY herein shall with regard to such Manufacture be deemed to
include a reference to such Sub-Contractor. BAXTER ONCOLOGY shall notify THRESHOLD of the appointment of any Sub-Contractor and provide a summary of the terms thereof (other than financial terms) as soon as reasonably practicable following such
appointment. 

  

	 	14.7	No Agency 

  
 Except as expressly stated in this Agreement, neither party shall act or describe itself as the agent of the other nor shall it make, or represent that it
has authority to make, any commitments on the other’s behalf. 
  

 29 

	 	14.8	Notices 

  

	 	14.8.1	 Any notice or other document given under this Agreement shall be in writing in the English language and shall be given by hand or sent by prepaid airmail, by facsimile
transmission or e-mail to the address of the receiving party as set out in Clauses 14.8.3 and 14.8.4 below unless a different address or facsimile number has been notified to the other in writing for this purpose. 

  

	 	14.8.2	 Each such notice or document shall: 

  

	 	(a)	if sent by hand, be deemed to have been given when delivered at the relevant address; 

  

	 	(b)	if sent by prepaid airmail, be deemed to have been given 7 (seven) days after posting; and 

  

	 	(c)	if sent by facsimile transmission or e-mail be deemed to have been given when transmitted provided that a confirmatory copy of such facsimile transmission or e-mail shall have been
sent by prepaid first class mail within 24 (twenty-four) hours of such transmission. 

  

	 	14.8.3	 BAXTER and BAXTER ONCOLOGY’s address for service of notices and other documents shall be: 

  
 BAXTER ONCOLOGY GmbH 
 Daimlerstrasse 40 
 60314 Frankfurt 
 Germany 
  
 For the Attention
of: Geschaeftsfuehrung 
  
 With a copy to: 
 BAXTER Deutschland GmbH 
 Legal Department

 Edisonstr. 4 
 D-85716
Unterschleissheim 
 Germany 
  

	 	14.8.4	 THRESHOLD’s address for service of notices and other documents shall be: 

  
 THRESHOLD PHARMACEUTICALS, INC. 
 951 Gateway Boulevard, Suite 3A 
 South San Francisco, CA 94080 
 United States of America 
 For the Attention
of: The Chief Executive Officer 
  

 30 

 With a copy to: 
  
 Heller Ehrman White & McAuliffe, LLP 
 275 Middlefield Road 
 Menlo Park, CA 94025 
 For the Attention of: Sarah O’Dowd 
  

	 	14.9	Entire Agreement 

  

	 	14.9.1	 This Agreement shall constitute the entire agreement and understanding of the Parties relating to the subject matter of this Agreement and shall supersede all prior oral or
written agreements, understandings or arrangements between them relating to such subjects. 

  

	 	14.9.2	 No change or addition may be made to this Agreement except in writing signed by the duly authorised representatives of the Parties. 

  

	 	14.9.3	 Nothing in this Clause 14.9 shall operate to: 

  

	 	(a)	exclude any provision implied into this Agreement by law and which may not be excluded by law; or 

  

	 	(b)	limit or exclude any liability, right or remedy to a greater extent than is permissible under law. 

  

	 	14.10 	Compliance with Local Requirements 

  
 If in any country the effect of any provision(s) of this Agreement or the absence from this Agreement of any provision(s) would be to prejudice the
Licensed Patents or any remedy under the Licensed Patents, the Parties will make such amendments to this Agreement and execute such further agreements and documents limited to that part of the Territory which falls under such jurisdiction as may be
necessary to remove such prejudicial effects. 
  

	 	14.11 	Publicity 

  
 The Parties may jointly agree to make a press release within three (3) months following the execution of this Agreement. Thereafter, Threshold shall be
free, in its sole discretion, and have the exclusive right to originate any publicity, news release, or public announcement concerning Licensed Products, provided Threshold (i) provides BAXTER ONCOLOGY two (2) days’ advance written notice of
the publicity, news release, or public announcement together with its content and gives due consideration to any comments provided by BAXTER ONCOLOGY within one (1) day thereof; and (ii) does not use the name of BAXTER or BAXTER ONCOLOGY without the
express, advance written consent of BAXTER or BAXTER ONCOLOGY, respectively, other than to state that the Licensed Product is “licensed to Threshold Pharmaceuticals, Inc., by Baxter Oncology.” Otherwise, in the absence of specific
agreement 

  

 31 

 
between the Parties, which agreement shall not be unreasonably withheld or delayed: (i) neither Party shall originate any publicity, news release or public
announcement, written or oral, whether to the public or press, relating to financial provisions of this Agreement or to any amendment thereof save only such announcement as in the opinion of counsel for the Party making such announcement is required
by law, regulation, or the rules of any stock exchange to be made, (ii) any such announcements shall be factual and as brief as possible, and (iii) if a Party decides to make such announcement, it will give the other Party two (2) days advance
written notice of the text of the announcement so that the other Party will have an opportunity to comment upon the announcement. In addition, THRESHOLD may provide information concerning financial provisions to stockholders, executive management,
and prospective sublicensees and investors. THRESHOLD may also originate, in its discretion, publicity, news releases, or public announcements concerning Licensed Product other than, except as set forth above, financial information. 
  

	 	14.12 	Notification to European Commission and Compliance with Hart Scott Rodino 

  
 The Parties shall co-operate fully and shall individually and collectively use all reasonable endeavours to procure any governmental or regulatory
approvals with regard to applicable anti-trust and competition law as may be necessary or advisable in connection with the conclusion and/or implementation of this Agreement are obtained as soon as possible. BAXTER ONCOLOGY will pay the costs of any
filing fees required to be paid in connection with such submissions or approvals. 
  

	15.	Arbitration; Governing Law 

  

	 	15.1	The construction, validity and performance of this Agreement shall be governed in all respects by the laws of the State of California without taking into consideration any of its
conflict of laws provisions. 

  

	 	15.2	The Parties will attempt in good faith to resolve any dispute, controversy or claim arising out of or relating to the interpretation, performance or enforceability of this Agreement
promptly by negotiation between executives of the Parties. In the event that such negotiations do not result in a mutually acceptable resolution, the Parties agree to consider other dispute resolution mechanisms including mediation and arbitration.
In the event that the Parties fail to agree on a mutually acceptable solution within a period of thirty (30) business days, any such dispute shall be submitted to binding arbitration. 

  

	 	15.3	 Such arbitration shall be conducted in accordance with the American Arbitration Association. Notwithstanding those rules, the following 

  

 32 

	 	 
provisions shall in any event apply to any issue submitted for arbitration hereunder: 

  

	 	15.3.1	 The arbitration shall be conducted by a panel of three (3) neutral arbitrators (“Panel”). One (1) arbitrator shall be appointed by each Party and the third member
shall be appointed by the two (2) arbitrators appointed by the Parties. Each Party will select an arbitrator within fifteen (15) business days following the demand for arbitration. The two (2) arbitrators selected by the Parties will appoint the
third arbitrator within ten (10) days following their appointment. Notwithstanding the above and in the interest of obtaining a judgment within the shortest possible period in connection with certain bona fide disputes or technical or developmental
matters that require referral to independent experts, the Parties may agree to appoint only one (1) single neutral arbitrator selected in agreement by both Parties. 

  

	 	15.3.2	 The language to be used in the arbitration shall be English. 

  

	 	15.3.3	 Any arbitrator selected by the Parties may be of any nationality, and need not be a lawyer or hold any other professional status or membership but will be selected on the
basis of his or her qualifications and expertise with respect to the matter under dispute. 

  

	 	15.3.4	 The arbitration shall be held in New York, New York. 

  

	 	15.3.5	 The specific pleading schedule for each proceeding shall be determined by the Parties in consultation with the Panel within fifteen (15) business days following the selection
of the arbitrators. 

  

	 	15.3.6	 Unless the Parties otherwise agree at the time a particular issue is submitted for arbitration, the Panel shall be required as a condition to their engagement to agree to
render a decision within thirty (30) days of the date on which the record in the proceeding is completed, but in no case more than one hundred and twenty (120) days after the date of their engagement. The time period for cure specified in Clause 11
shall be suspended upon institution of arbitration until completion of such arbitration. 

  

	 	15.3.7	 The Parties shall use their best efforts to schedule and make their submissions, and to take all other necessary actions in connection with the proceeding, at a time and in a
manner which will permit the Panel to render their decision in accordance with the schedule set forth herein. 

  

	 	15.3.8	  All communications with the arbitrator(s) during the proceeding shall be made in writing, with a copy thereof delivered simultaneously to the other Party to
the proceeding, or if made 

  

 33 

	 	 
orally, made only in the presence of the other Party to the proceeding or its representative. 

  

	 	15.3.9	 All decisions by the Panel shall be rendered by majority vote. The arbitration award or order shall be rendered in writing and shall be final and binding upon the Parties. The
arbitrator(s) shall establish and enforce appropriate rules to ensure that the arbitration proceedings, including the decisions, are kept confidential and that all confidential and/or proprietary information of the Parties is kept confidential and
is used for no purpose other than for such arbitration proceedings. 

  

	 	15.3.10	 Judgment on any order or award shall be entered by any court of competent jurisdiction. 

  

	 	15.3.11	 Each Party shall bear its own expenses and attorney’s fees in connection with the arbitration. 

  

	 	15.3.12	 The fees and expenses of the arbitrator(s) shall be equally shared except that if, in the opinion of the arbitrators, any claim by a Party hereto or any defense or objection
thereto by the other Party was unreasonable and frivolous, the arbitrators may in their discretion assess as part of the award all or any part of the arbitration expenses of the other Party (including reasonable attorney’s fees) and expenses of
the arbitrators against the Party raising such unreasonable and frivolous claim, defense or objection. 

  
 In Witness Whereof the duly authorized representatives of the Parties have executed this Agreement the day and year written below 
  

					
	 Date: July 29, 2003
	 	 	 	 Date: August 5, 2003

			
	 /s/ Phillip Saame
	 	 	 	 /s/ George F. Tidmarsh

	
	 	 	 	

	 /s/ Bernhard Kutscher
	 	 	 	 Signed by George F. Tidmarsh
 For and on behalf of
 THRESHOLD Pharmaceuticals Inc.

	
	 	 	 
	 Signed by Phillip Saame & Bernhard Kutscher
 For and on behalf of
 BAXTER ONCOLOGY GmbH
	 	 	 

  

					
	 Date: July 31, 2003
	 	 	 	 
			
	 /s/ Jan Stern Reed
	 	 	 	  
	
	 	 	 	 
	 Signed by Jan Stern Reed
 For and on behalf of
 BAXTER International Inc.
	 	 	 	 

  

 34 

 Schedules 
  

			
	 Schedule 1.4:
	  	Licensed Patents:
	 	  	Part A                Baxter Oncology Patents
		
	 	  	Part B                 Manufacturing Patents
		
	 Schedule 1.15:
	  	License Grant from DKFZ

  

 35 

 SCHEDULE 1.4 
  
 Part A: Baxter Oncology Patents 
  
 Patents based on German Application P 38 35 772.0. 
  
 Title: “Antitumor Saccharide Conjugates”, covering molecule, production and medical use 
  

	1.	Patent No:        EP 369 182 

  

	2.	Patent No:        AT 369 182 

  

	3.	Patent No:        BE 369 182 

  

	4.	Patent No:        CA 2 001 129 

  

	5.	Patent No:        CH 369 182 

  

	6.	Patent No:        DE 369 182 

  

	7.	Patent No:        DK 170 422 

  

	8.	Applic. No:      DK 1170/93        Notice of allowance received 

  

	9.	Patent No:        ES 369 182 

  

	10.	Patent No:        FI 95 268 

  

	11.	Patent No:        FR 369 182 

  

	12.	Patent No:        GB 369 182 

  

	13.	Patent No:        GR 369 182 

  

	14.	Patent No:        HK 1574/1995 

  

	15.	Patent No:        HU 206 124 

  

	16.	Patent No:        IE 67 529 

  

	17.	Patent No:        IT 369 182 

  

	18.	Patent No:        JP 2 518 739 

  

	19.	Patent No:        JP 3 056 408 

  

	20.	Patent No:        LU 369 182 

  

	21.	Patent No:        NL 369 182 

  

	22.	Patent No:        NO 173 548 

  

	23.	Patent No:        PT 92 034 

  

	24.	Patent No:        SE 369 182 

  

	25.	Patent No:        SG 95 913 

  

	26.	Patent No:        US 5 622 936 

  

 36 

 Part B. Patent covering production 
  
 Title: “Verfahren zur Herstellung von Tetrabenzylglucose” (Procedure for the production of Tetrabenzylglucose) 

 

	27.	Patent No:        DE 195 34 366 

  

 37 

 Schedule 1.15 
  
  
 Kooperations- und Lizenzvertrag 
  
 zwischen 
  
 der Firma ASTA Pharma Aktiengesellschaft, Weismüllerstr. 45, D-6000 Frankfurt a. M. 1, 
  
 - im folgenden “ASTA Pharna” genannt - 
  
 und 
  

dem Deutschen Krebsforschungszentrum, Stiftung des öffentlichen Rechts, Im Neuenheimer Feld 280, D-6900 Heidelberg 1, 
  
 - im folgenden “DKFZ” genannt -. 
  
 Präambel: 
  
 Das DKFZ und ASTA Pharma haben in den letzten drei Jahren erfolgreich auf dem Gebiet der Entwicklung von Substanzen mit tumorhemmender und
antimetastatischer Wirkung zusammengearbeitet. 
  
 Dabei wurden vom DKFZ durch
Prof. Wießler (“Forschungsleiter”) Substanzen entwickelt, die durch die Mitwirkung von ASTA Pharma zu der deutschen Patentanmeldung Nr. P 3835 772.0 sowie der europäischen Patentanmeldung No. 89 119 408.6 und der internationalen
Patentanmeldung PCT/EP 89/01251 für bestimmte Länder geführt haben. Das DKFZ ist bemüht, durch den Forschungsleiter und andere Mitarbeiter weitere Substanzen zu entwickeln. 
  

 38 

 ASTA Pharma ist bereit, die genannten Arbeiten des DKFZ finanziell zu unterstützen. Dafür wird das DKFZ
bestehende oder zukünftige Patentanmeldungen bzw. Patente auf ASTA Pharma übertragen. 
  
 Zur Regelung der sich aus dieser Kooperation ergebenden Rechte und Pflichten vereinbaren die Vertragspartner folgendes: 
  
 § 1 
  
 Definitionen 
  

	1.1	Der Begriff “Substanzen” umfaßt sowohl vorhandene wie auch zukünftige Substanzen. 

  
 “Vorhandene Substanzen” sind die zwei vom DKFZ synthetisierten Stoffe, die zu der deutschen Patentanmeldung Nr. P
3835 772.0, der europäischen Patentanmeldung No. 89 119 408.6 sowie der internationalen Patentanmeldung PCT/EP 89/01251 für bestimmte Länder gemäß Anlage 2 geführt haben. 
  
 “Zukünftige Substanzen” sind die im Rahmen der
Forschungsarbeit vom DKFZ synthetisierten Stoffe mit tumorhemmender und antimetastatischer Wirkung. 
  

	1.2	Der Begriff “Forschungsarbeit(en)” umfaßt diejenigen von ASTA Pharma nach diesem Vertrag finanzierten oder hiermit im Zusammenhang stehenden, vom DKFZ durch den
Forschungsleiter und andere Mitarbeiter durchgeführten Arbeiten nach dem in Anlage 1 beigefügten, fortzuschreibenden Arbeitsprogramm mit Ablaufplan. 

  

	1.3	Der Begriff “Ausgangsstoffe” umfaßt alle Stoffe, die zur Herstellung von vorhandenen oder zukünftigen Substanzen erforderlich sind. 

	1.4	Der Begriff “Vertragsschutzrechte” umfaßt die in Anlage 2 genannten Patentanmeldungen, die darauf zur Erteilung gelangenden Patente sowie künftige Schutzrechte,
die sich auf die vorhandenen oder zukünftigen Substanzen beziehen. 

  

	1.5	Der Begriff “Vertraqsprodukt(e)” umfaßt alle Produkt 

  

	1.6	Der Begriff “Nettowarenerlös” umfaßt den Bruttoerlös ex factory mit einem Vertragsprodukt abzüglich Umsatzsteuer und abzüglich einer Pauschale
von 10% zur Abdeckung aller Verkaufskosten. 

  
 § 2 
  
 Pflichten des DKFZ 
  

	2.1	Das DKFZ wird im Rahmen der Forschungsarbeiten aus Ausgangsstoffen Substanzen synthetisieren, die bei ASTA Pharma auf ihre pharmakologische Wirksamkeit getestet werden sollen.

  

	2.2	Das DKFZ wird zur Herstellung der vorhandenen und zuküftigen Substanzen Ausgangsstoffe von ASTA Pharma beziehen und die bezogenen Ausgangsstoffe ausschließlich für
die Herstellung der vorhandenen und zukünftigen Substanzen verwenden. ASTA Pharma ist bereit, die für die Forschungsarbeiten benötigten Ausgangsstoffe kostenlos an das DKFZ zu liefern. Bei Beendigung der Forschungsarbeiten wird das
DKFZ die noch vorhandenen und nicht bearbeiteten Ausgangsstoffe an ASTA Pharma zurückgeben. 

  

	2.3	Bis zu dem jeweiligen kompletten Abschluß der präklinischen und toxikologischen Arbeiten wird das DKFZ ASTA Pharma mit vorhandenen und zukünftigen Substanzen
beliefern. Hierfür stellt das DKFZ die benötigten Laborkapazitäten sowie vorhandene Infrastruktur zur Verfügung. 

  

	2.4	 Das DKFZ ist für die ordnungsgemäße Lagerung der von ASTA Pharma bezogenen Ausgangsstoffe verantwortlich. Angelieferte fehlerhafte 

	 	 
Ausgangsstoffe sind vom DKFZ unverzüglich zu beanstanden. Für den Fall der Beschädigung oder des Verlustes von Ausgangsstoffen nach deren
Anlieferung verplichtet sich das DKFZ, ASTA Pharma den Wert der angelieferten Ausgangsstoffe zum Marktpreis zu erstatten. 

  

	2.5	Durch diesen Vertrag werden keine arbeitsrechtlichen Beziehungen zwischen ASTA Pharma und auf Seiten des DKFZ an den Forschungsarbeiten Beteiligten begründet.

  
 § 3 
  
 Kostenbeitrag 
  
 Zur Durchführung der in § 2 genannten Arbeiten wird ASTA Pharma dem DKFZ als Optionsgebühr für die Dauer
von 2 Jahren eine jährliche finanzielle Unterstützung in Höhe von DM 150.000,— zur Verfügung stellen, die jeweils zur Hälfte am 01.04. und am 01.10. eines jeden Vertragsjahres fällig ist. 
  
 § 4 
  
 Vertragsschutzrechte 
  

	4.1	Die Parteien werden sich während der Durchführung der Forschungsarbeiten laufend über die Ergebnisse der Forschungsarbeiten informieren. Nach Absprache mit ASTA
Pharma wird das DKFZ schriftlich über den Fortgang der Forschungsarbeiten berichten. 

  

	4.2	Die wirtschaftliche Verwertung der Ergebnisse von Forschungsarbeiten steht ausschließlich ASTA Pharma zu. Das DKFZ wird die Verfügbarkeit der Ergebnisse von
Forschungsarbeiten sicherstellen und alle Rechte an diesen Ergebnissen einschließlich der Erfindungen auf ASTA Pharma übertragen. 

  

	4.3	 ASTA Phdrma ist berechtigt, für die Ergebnisse der Forschungsarbeiten im eigenen Namen in beliebigen Ländern Schutzrechtsanmeldungen auf eigene 

	 	 
Kosten zu tätigen. Das DKFZ wird ASTA Pharma bei der Erlangung von Vertragsschutzrechten auf Wunsch von ASTA Pharma mit allen verfügbaren Mitteln
unterstützen. 

  

	4.4	Sollte ASTA Pharma an der Schutzrechtsarmoldung von Ergebnissen der Forschungsarbeiten nicht interessiert sein, werden die Parteien darüber verhandeln, ob das DKFZ das Recht
zur Schutzrechtsanrneldung erhält. ASTA Pharma soll sich einem dahingehenden Wunsch des DKFZ nur bei einem erheblichen eigenen Interesse an der Nichtanmeldung widersetzen. 

  

	4.5	Das DKFZ überträgt ASTA Pharma alle Rechte an seiner deutschen Patentanmeldung “Tumorhemmende Saccharid-Konjugate” Nr. P 3835 772.0 sowie alle Schutzrechte bzw.
Schutzrechtsanmeldungen, die vom DKFZ parallel dazu gemäß Anlage 2 vorgenommen worden sind. Von der Vergütung, die nach dem Gesetz über Arbeitnehmererfindungen für die Inanspruchnahme der den Schutzrechten bzw.
Schutzrechtsanmeldungen gemäß Anlage 2 zugrundeliegenden Erfindungen zu zahlen ist, steht den Erfindern von ASTA Pharma ein Anteil von 20% zu. Diesen Anteil darf ASTA Pharma von einer an das DKFZ gemäß § 5.1 zu zahlenden
Vergültung vorab in Abzug bringen. 

  

	4.6	ASTA Pharma ist nicht verpflichtet, die Vertragsschutzrechte nach der Erteilung von Patenten aufrechtzuerhalten. Falls ASTA Pharma sich gegen eine Aufrechterhaltung entscheidet,
erlangt das DKFZ ein Optionsrecht auf die Übertragung dieser Vertragsschutzrechte zu noch näher festzulegenden Bedingungen. 

  
 § 5 
  
 Finanzielle Beteiligung an wirtschaftlicher Verwertung 

	5.1	Als Gegenleistung für die Übertragung der Rechte gemäß § 4 zahlt ASTA Pharma an das DKFZ eine umsatzbezogene Vergütung für den Verkauf von
Vertragsprodukten. 

  

	 	a)	Diese Vergütung beträgt 3% der Nettowarenerlöse pro Vertragsprodukt in einem Vertriebsland, soweit these Erlöse von ASTA Pharma oder Gesellschaften erzielt
werden, an denen ASTA Pharma mit wenigstens 50% des Kapitals beteiligt ist und soweit das Vertragsprodukt in dem jeweiligen VertriebsIand von rechtsbeständigen Vertragsschutzrechten erfaßt wird. 

  

	 	b)	Die Vergütung beträgt für eine Dauer von höchstens 10 Jahren ab erstmaliger Ausbietung in dem Vertriebsland 2% der Nettowarenerlöse pro Vertragsprodukt in
dem Vertriebsland, soweit these Erlöse von ASTA Pharma oder Gesellschaften erzielt werden, an denen ASTA Pharma mit wenigstens 50% des Kapitals beteiligt ist und soweit das Vertragsprodukt in dem jeweiligen Vertriebsland nicht von
rechtsbeständigen Vertragsschutzrechten erfaßt wird, diese aber im Lande der Herstellung bestehen. 

  

	 	c)	Die Vergütung beträgt in den Fällen von a) und b)—bei ansonsten gleichen Voraussetzungen—im Falle der Erzielung der Warenerlöse durch sonstige
Lizenznehmer von ASTA Pharma 2 Prozentpunkte der durch ASTA Pharma von diesen Lizenznehmern vereinnahmten laufenden Schutzrechtslizenzgebühren. 

  
 Die zuvor in § 5.1 genannten Prozentzahlen bzw. Prozentpunkte hinsichtlich der Vergütung gelten für den Fall,
daß dem DKFZ an den in Bezug genommenen Vertragsschutzrechten ein Erfinderanteil von 100% zusteht. Ist der Erfinderanteil des DKFZ geringer, so verringern sich die genannten Prozentzahlen bzw. Prozentpunkte entsprechend. 

	5.2	Mit den unter § 5.1 genannten Vergütungen sind auch alle eventuellen Ansprüche von beteiligten Mitarbeitern des DKFZ, insbesondere im Hinblick auf die Bestimmungen
des Arbeitnehmererfindungsgesetzes, abgegolten. 

  

	5.3	Die nach § 5.1 zu zahlende Vergütung wird von ASTA Pharma zum 31.03. und zum 30.09. eines jeden Jahres errechnet und innerhalb eines darauffolgenden Zeitraumes von 8
Wochen bezahlt. Die Grundlagen der Berechnung werden dem DKFZ auf Wunsch zur Einsicht überlassen. 

  
 § 6 
  
 Vertraulichkeit 
  

	6.1	Alle von einer Partei der anderen übergebenen Informationen sind von der anderen Partei streng vertraulich zu behandeln. Die Geheimhaltungspflicht entfällt für jede
Partei, soweit ihr die Informationen zum Zeitpunkt der Übermittlung nachweislich schon bekannt sind oder infolge von Publikationen oder sonstigem Bekanntwerden Gemeingut sind bzw. werden oder nachweislich von anderer Seite bekanntgemacht
werden, ohne direkt oder indirekt von einer der Parteien zu stanunen. Nicht als Verletzung der Geheimhaltungspflicht angesehen wird die zur amtlichen Offenlegung führende Einreichung von Patentanmeldungen durch ASTA Pharma, die Einreichung von
Unterlagen in Zulassungsverfahren und die erforderliche Mitteilung an Angehörige der Heilberufe. 

  

	6.2	Eine Veröffentlichung der Ergebnisse von Forschungsarbeiten durch das DKFZ oder seine Mitarbeiter sowie durch Mitarbeiter von ASTA Pharma bedarf der vorherigen Zustimmung
beider Vertragsparteien. Die Zustimmung einer Partei zur Veröffentlichung gilt spätestens 45 Tage nach Vorlage der beabsichtigten Veröffentlichung als erteilt, falls diese Partei der Veröffentlichung innerhalb dieses Zeitraumes
nicht widerspricht. Widerspricht ASTA Pharma einer Veröffentlichung, so werden die Vertragspatner innerhalb von 3 Monaten eine Einigung über die Veröffentlichung einvernehmlich herbeiführen. 

 § 7 
  
 Vertragsdauer 
  

	7.1	Dieser Vertrag tritt nach ünterzeichnung der Parteien am 01.01.1990 in Kraft. 

  

	7.2	Der vertrag endet mit Ablauf des am längsten laufenden Vertragsschutzrechtes. 

  
 § 8 
  
 Formerfordernis 
  
 Änderungen oder Ergänzungen dieser Vereinbarung bedürfen der Schriftform und der Zustimmung der Parteien. 
  
 § 9 
  
 Salvatorische Klausel 
  
 Sollten eine oder mehrere Bestimmungen dieses Vertrages ganz oder teilweise unwirksam sein oder ihre Rechtswirksamkeit später verlieren, so soll
hierdurch die Gültigkeit der übrigen Bestimmungen nicht berührt werden. Anstelle der unwirksamen Bestimmung soll—soweit rechtlich zulässig—eine andere angemessene Regelung in Kraft treten, die wirtschaftlich dem am
nächsten kommt, was die Vertragsparteien gewollt haben oder gewollt hätten, wenn sie die Unwirksamkeit der Regelung oder das Vorliegen einer Regelungslücke bedacht hätten. 
  
 § 10 
  
 Erfüllungsort und Gerichtsstand 
  

Erfüllungsort und Gerichtsstand ist Heidelberg. 
  

							
	Frankfurt a. M., den	  	    02.04.1990            	  	Heidelberg, den	  	    06.04.1990            

							
	 	  	 	  	 Deutsches Krebsforschungszentrum,
 Stiftung des öffentlichen Rechts

  
                 /German original signed/                 /German original
signed/                 /German original signed/                 
  

							
	ASTA Pharma Aktiengesellschaft	  	Prof. Dr. Dr. h.c. H. zur Hausen
			
	 Dr. Rutz
	  	 Prof. Engel
	  	 Wissenschaftlicher Stiftungsvorstand

			
	 	  	 	  	 /German original
signed/                

			
	 	  	 	  	 Dr. R. Grunwald

			
	 	  	 	  	 Adm. Stiftungsvorstand

 Kosten für die Patentanmeldung P 38 35 772.0 
  

						
	 Einreichung der deutschen Patentanmeldung
	  	R. v. 31.10.88	  	DM	4.122,40
	 Kommentierung des Amtsbescheids (DPA)
	  	R. v. 24.04.89	  	DM	478,—
	 Ausarbeitung einer Eingabe (DPA)
	  	R. v. 21.08.89	  	DM	7.011,—
	 Einreichung einer PCT-Anmeldung
	  	R. v. 26.10.89	  	DM	7.011,—
	 Einreichung einer Europa-Anmeldung
	  	R. v. 26.19.89	  	DM	8.104,—
	 Einreichung einer irischen Patentanmeldung
	  	R. v. 27.10.89	  	DM	5.442,36
	 Einreichung japan. Patentanmeldung
	  	R. v. 10.11.89	  	DM	6.024,—
	 Einreichung einer dänischen Patentanmeldung
	  	R. v. 10.11.89	  	DM	5.394,48
	 Einreichung einer kanad. Patentanmeldugn
	  	R. v. 16.11.89	  	DM	5.507,34
	 Komnentierung eines Amtsbescheids (DPA)
	  	R. v. 22.12.89	  	DM	364,80
	 Komnentierung eines Amtsbescheids (EP-Anm.)
	  	R. v. 05.01.90	  	DM	1.564,08
	 Anfertigung geänderter Unterlagen und Zeichnungen für EP-  und PCT-Anmeldung
	  	R. v. 30.01.90	  	DM	929,10
	 Fristverlängerung (DPA)
	  	R. v. 03.04.90	  	DM	114,—
	 Kommentierung Amtsbescheid (PCT)
	  	R. v. 05.04.90	  	DM	326,04
	 Kommentierung Amtsbescheid (EPA)
	  	R. v. 05.04.90	  	DM	326,04
	 	  	 	  	
	

	 	  	 	  	DM	  46.500,84

  
 Zwecks Vereinfachung des
Zahlungsverkers schlagen wir vor, daß unser Patentanwalt Ihnen in Zukunft die Rechnungen direkt zuleiten wird. Wir bitten um die Angabe der dafür zuständigen Abteilung. 

 Translation from the German Language 
  
 Cooperation and License Agreement 
  
 between 
  
 ASTA Pharma Aktiengesellschaft (= Corporation), Weismuellerstrasse 45, D-6000 Frankfurt on-the-Main 1, 
  
 - hereinafter referred to as “ASTA Pharma” - 
  
 and 
  

the German Cancer Research Center, Foundation under Public Law, Im Neuenheimer Feld 280, D—6900 Heidelberg 1, 
  
 - hereinafter referred to as “DKFZ”-. 
  
 Preamble: 
  
 During the last three years, DKFZ and ASTA Pharma have worked together successfully in the field of the development of substances with a
cytostatic and antimetastatic effect. 
  
 In this framework, DKFZ through Prof.
Wiessler (“Research Director”) has developed substances which have led in collaboration with ASTA Pharma to the German Patent Application No. P 3835 772.0 as well as to the European Patent Application No. 89 119 408.6 and, finally, to the
international Patent Application PCT/EP 89/01251 for certain countries. DKFZ endeavors to develop further substances through the Research Director and other staff. 
  
 ASTA Pharma is willing to provide financial support for the above mentioned projects of DKFZ. In return, DKFZ agrees to assign any existing
or future patent applications or patents to ASTA Pharma. 

 In order to stipulate the rights and obligations arising from this cooperation, the contractual parties agree on the
following: 
  
 § 1 
  
 Definitions 
  

	1.1	The term “Substances” shall include any existing as well as any future substances. 

  
 “Existing Substances” shall mean the two substances synthesized by DKFZ which have led to the German Patent
Application No. P 3835 772.0, the European Patent Application No. 89 119 408.6 as well as to the international Patent Application PCT/EP 89/01251 for certain countries, as specified in Annex 2. 
  
 “Future Substances” shall mean any substances with a cytostatic
and antimetastatic effect which will be synthesized by DKFZ in the framework of its research works. 
  

	1.2	The term “Research Works” shall include such work as described in the enclosed work program with activity schedule (to be updated, see Annex 1) which is financed by ASTA
Pharma under the terms of this Agreement or in relation herewith and which will be performed by DKFZ through the Research Director and other staff members. 

  

	1.3	The term “Starting Materials” shall include all such materials which may be required for the production of the existing as well as of any future substances.

  

	1.4	The term “Contractual Protective Rights” shall mean the patent applications as listed in Annex 2, the patents to be granted in this respect as well as any future
protective rights related to the existing as well as the future substances. 

  

	1.5	The term “Contractual Product(s)” shall mean all such products which will be produced on the basis of the substances. 

	1.6	The term “Net Sales Revenue” shall mean the gross revenue ex factory obtained for a contractual product minus turnover tax as well as minus a flat rate of 10 percent to
cover all sales costs. 

  
 § 2

  
 Duties of DKFZ 
  

	2.1	In the scope of the research works, DKFZ undertakes to synthesize substances from the starting materials which then shall be tested at ASTA Pharma for their pharmacological
efficacy. 

  

	2.2	For the purpose to produce the existing as well as any future substances, DKFZ will be provided with starting materials from ASTA Pharma and undertakes to use these starting
materials exclusively for the production of such existing and future substances. ASTA Pharma is willing to supply the starting materials required for research works to DKFZ at no charge. At the completion of research works, DKFZ undertakes to return
to ASTA Pharma any unused starting materials that are still available. 

  

	2.3	Until the respective ultimate completion of the preclinical and toxicological work, DKFZ shall supply ASTA Pharma with the existing and future substances. For this purpose, DKFZ
undertakes to make available the required laboratory capacities as well as the existing infrastructure. 

  

	2.4	DKFZ shall be responsible for proper storage of the starting materials obtained from ASTA Pharma. Receipt of defective starting materials shall be reported immediately by DKFZ. In
case of damage to or loss of starting materials after their delivery, DKFZ undertakes to reimburse ASTA Pharma for the value of the delivered starting materials on the basis of the market price. 

	2.5	This Agreement shall not establish any relation under the labor law between ASTA Pharma and any of the employees who are involved in the research works on the side of DKFZ.

  
 § 3 
  
 Contribution 
  
 For the purpose to perform the work described under § 2, ASTA Pharma
shall make available to DKFZ for the period of two years a yearly financial support in the amount of DM150,000.00 in form of an option fee. One half each of this amount shall be due and payable on April 01 and on October 01, respectively, of each
contractual year. 
  
 § 4 
  
 Contractual Protective Rights 
  

	4.1	For the duration of the research works, the Parties undertake to keep each other’ informed about the results of their research works. As per agreement with ASTA Pharma, DKFZ
shall inform about the progress of research works in form of written reports. 

  

	4.2	Only ASTA Pharma shall have the right to an economic exploitation of the results of these research works. DKFZ shall ensure the availability of the results of the research works and
shall assign all rights to these results (including the inventions) to ASTA Pharma. 

  

	4.3	ASTA Pharma shall be entitled to apply at its own name and at its own costs in any country for protective rights with regard to the results of the research works. Upon the request
of ASTA Pharma, DKFZ shall assist ASTA Pharma concerning the acquisition of contractual protective rights by every available means. 

	4.4	In a case where ASTA Pharma may not be interested in the application of protective rights for certain results of the research works, the Parties shall negotiate whether DKFZ shall
be granted the right to apply for such protective rights. Unless there is a considerable own interest in non-application, ASTA Pharma shall not oppose a relevant request made by DKFZ. 

  

	4.5	DKFZ shall assign to ASTA Pharma all rights to its German Patent Application “Cytostatic Saccharide Conjugates” (No. P 3835 772.0) as well as all protective rights or
copending applications for protective rights which DKFZ has arranged for according to Annex 2. Of the compensation that has to be paid in compliance with the Law on Employee Inventions for the utilization of inventions which form the basis of the
protective rights or applications for protective rights according to Annex 2, the inventors of ASTA Pharma shall be entitled to a share of 20 percent. ASTA Pharma shall have the right to deduct this percentage in advance from a compensation that may
become payable to DKFZ pursuant to § 5.1. 

  

	4.6	ASTA Pharma shall not be obliged to maintain the Contractual Protective Rights after patents have been granted. In case ASTA Pharma should decide against such maintenance, DKFZ
shall acquire an option right to the assignment of these Contractual Protective Rights under conditions that need to be defined in more detail later on. 

  
 § 5 
  
 Financial Participation in an Economic Exploitation 
  

	5.1	In return for the assignment of the rights pursuant to § 4, ASTA Pharma agrees to pay to DKFZ a sales-related compensation for the sale of contractual products.

  

	 	a)	 This compensation shall amount to 3% of the net sales revenues per contractual product in a sales country, provided that these revenues are achieved by ASTA Pharma
or by companies in which ASTA Pharma is 

	 	 
holding at least 50% of the capital, and provided that the contractual product is covered by lawful contractual protective rights in the respective sales
country. 

  

	 	b)	For a period of not more than 10 years after the product has been initially put up for sale in the respective sales country, the compensation shall amount to 3% of the net sales
revenues per contractual product in this sales country, provided that these revenues are achieved by ASTA Pharma or by companies in which ASTA Pharma is holding at least 50% of the capital, and as far as the contractual product is not covered by
lawful contractual protective rights in the respective sales country, however, where such contractual protective rights exist in the producer country. 

  

	 	c)	If the sales revenues are achieved by other licensees of ASTA Pharma, the compensation shall amount in the cases of a) and b)—under the same conditions—to 2 percent points
of the current royalty for the protective rights collected by ASTA Pharma from these licensees. 

  
 The percentages or percent points mentioned above in § 5.1 in respect to the compensation shall apply in those cases, where DKFZ is entitled to an
inventor’s share of 100% in the relevant contractual protective rights. Should the inventor’s share of DKFZ be less than that, the above mentioned percentages or percent points shall be reduced accordingly. 
  

	5.2	By payment of the compensations mentioned in § 5.1, any potential claims of involved staff members of DKFZ (in particular in respect of the stipulations provided by the Law on
Employee Inventions) shall be settled as well. 

  

	5.3	 The compensation payable according to § 5.1 shall be calculated by ASTA Pharma by the 31st of March and by the 30th
of September of each calendar year 

	 	 
and shall then be paid within the following 8 weeks. Upon request of DKFZ, the bases of this calculation will be made available for inspection.

  
 § 6 
  
 Secrecy 
  

	6.1	All information provided by one Party to the other one shall be treated strictly confidential by the receiving party. This obligation to maintain secrecy shall not apply in such
case where the information provided is evidently known already to the receiving Party at the moment it is communicated, or if it has entered the public domain already through publications or other announcement, or if it has been evidently announced
by third party without originating directly or indirectly from one of the Parties to this Agreement. Filing of patent applications by ASTA Pharma, submission of documents in the course of registration procedures as well as required notification to
health professionals which will lead to an official disclosure shall not be considered as a breach of the obligation to maintain secrecy. 

  

	6.2	Any publication of the results of the research works by DKFZ or its employees as well as by employees of ASTA Pharma shall require the prior approval of the two Parties to this
Agreement. Such approval of one Party to the publication shall be deemed as granted at the latest 45 days after the intended publication has been submitted, unless this Party does not oppose such publication within this period. In case ASTA Pharma
should oppose such publication, the Parties to this Agreement herewith undertake to bring about mutual consent concerning the publication within three months. 

 § 7 
  

Term of this Agreement 
  

	7.1	This Agreement shall become effective after being signed by the Parties on January 01, 1990. 

  

	7.2	This Agreement shall end when the contractual protective right with the longest term will expire. 

  
 § 8 
  
 Requirement of Form 
  
 Any modifications of or amendments to this Agreement shall be made out in written form and require the approval of the Parties. 
  
 § 9 
  
 Severability 
  
 Should any individual provision or any part of this Agreement be or become void or unenforceable, the validity of the remaining provisions hereof shall in
no way be affected. In such case the void and/or unenforceable provision or provisions shall be replaced (if permissible by the law) by relative provisions coming economically as close as possible to the sense and purpose of this Agreement as
intended by the Parties, if they would have been aware of such invalidity of the provision or of the presence of such a loophole. 

 § 10 
  

Place of Jurisdiction and Fulfillment 
  
 Heidelberg will be the place of jurisdiction and fulfillment. 
  

					
		
	 Frankfurt on-the-Main, this 2nd day of April 1990
	 	 Heidelberg, this 6th day of April 1990

			
	 	 	 	 	 German Cancer Research Center,
 Foundation under Public Law

			
	 //German original signed/
	 	 /German original signed
	 	        /German original signed/        
			
	 ASTA Pharma Aktiengesellschaft
 Dr. Rutz 
	 	 Prof. Engel
	 	 Prof. Dr. Dr. h.c. H. zur Hausen
 Scientific Director of the Foundation

			
	 	 	 	 	        /German original signed/        
			
	 	 	 	 	 Dr. R. Grunwald
 Administrative Director of the Foundation

 ANNEX 1) 
  
 Costs incurred for patent application P 38 35 772.0 
  

							
	 Filing of the German patent application
	  	Invoice dtd. 10/31/88	    	DM	 	4,122.40
	 Commentary on the official letter (DPA)*
	  	Invoice dtd. 04/24/89	    	DM	 	478.00
	 Preparation of a response/motion (DPA)
	  	Invoice dtd. 08/21/89	    	DM	 	7,011.00
	 Filing of a PTC* application
	  	Invoice dtd. 10/26/89	    	DM	 	7,011.00
	 Filing of a patent application for Europe
	  	Invoice dtd. 10/26/89	    	DM	 	8,104.00
	 Filing of a patent application for Ireland
	  	Invoice dtd. 10/27/89	    	DM	 	5,442.36
	 Filing of a patent application for Japan
	  	Invoice dtd. 11/10/89	    	DM	 	6,024.00
	 Filing of a patent application for Denmark
	  	Invoice dtd. 11/10/89	    	DM	 	5,394.48
	 Filing of a patent application for Canada
	  	Invoice dtd. 11/10/89	    	DM	 	5,507.34
	 Commentary on an official letter (DPA)
	  	Invoice dtd. 12/22/89	    	DM	 	364.80
	 Commentary on an official letter (Appl. EP)
	  	Invoice dtd. 01/05/90	    	DM	 	1,564.08
	 Preparation of amended documents and drawings for the EP and PCT application
	  	Invoice dtd. 01/30/90	    	DM	 	929.10
	 Extension of time (DPA)
	  	Invoice dtd. 04/03/90	    	DM	 	114.00
	 Commentary on an official letter (PCT)
	  	Invoice dtd. 04/05/90	    	DM	 	326.04
	 Commentary on an official letter (DPA)
	  	Invoice dtd. 04/05/90	    	DM	 	326.04
	 	  	 	    	

	 	  	 	    	DM	 	46,500.84

  

	*	DPA = German Patent Office 

  
 PTC = Patent Cooperation Treaty 
  
 In order to facilitate payment transactions, we would like to propose that in the future our Patent Attorney will send you the invoices directly. For this purpose,
please, let us know to which department they should be addressed to. 

 Letter of Assignment 
  
 The German Cancer Research Center, Foundation under Public Law, Im Neuenheimer Feld 280, 69120 Heidelberg, represented by Prof. Dr.
med. Dr. H.c. mult. H. zur Hausen and by Dr. rer. pol. J. Puchta, the Foundation Directors, 
  
 herewith assigns all rights and obligations in full arising from the German patent application “Cytostatic Saccharide Conjugates”, No. P 38 35 772.0, as well as the foreign protective rights based on this,
i.e. 
  
 European patent No. 0369 182 (AT, BE, CH, DE, ES, FR, GB, GR, IT, LU, NL,
SE, Hongkong, Singapore), 
  
 Irish patent application 3360/89 
 Portuguese patent 92 034 
 Hungarian patent 206 124 
 Norwegian patent 173 548 
 Danish patent 170422 
 US patent application 499 522 
 Canadian patent application 2 001 129.7

 Japanese patent 2 518 739 
  
 to the company 
  
 ASTA MEDICA 
  
 An der Picardie 10

  
 01277 Dresden 
  
 Heidelberg, this 3rd day of November 1997 
  
 German Cancer Research Center 
  
 Foundation under Public Law 
  

			
	 /German original signed/

	 	 /German original signed/

		
	 Prof. Dr. Dr. h.c. H. zur Hausen
 Scientific Director of
the Foundation
	 	 Dr. rer. pol. J. Puchta
 Administrative Director of
the Foundation

 Letter of Assignment 
  
 The company ASTA MEDICA, An der Picardie 10, 01277 Dresden, 
  
 herewith agrees to the assignment of the patent application No. 38 32 772.0 (“Saccharide Conjugates”) and of the resulting foreign
protective rights as specified in the foregoing Letter of Assignment. 
  
  
 Dresden, this 25th day of February
1998 
  
 ASTA MEDICA AG 
  

							
	 /German original signed/

	 	 /German original signed/

				
	 By proxy: 
 Geissler 
	 	 By proxy:
 Decker
	 	 	 	 

 Certification of Signatures 
  
 The foregoing signatures of 
  

	1.	Prof. Dr. Dr. h.c. Harald zur Hausen 
President of the Foundation Board 

  

	2.	Dr. Josef Puchta, 
Administrative Member of the Foundation Board, 

  
 both known to me in person and having their registered office at Im Neuenheimer Feld 280 in 69120 Heidelberg, 
  
 both acting in their above mentioned functions for the German Cancer Research Center,
Foundation under Public Law, having its registered office in Heidelberg, Im Neuenheimer Feld 280, 
  
 have been signed today in my presence, are herewith authenticated by myself and are hereby publicly attested to be true. 
  
 The original of the enclosed notarially authenticated copy of the official confirmation made out by the Ministry for Science, Research and Art of the Land
Baden-Wurttemberg (Stuttgart) in its function of the competent Foundation Authority, dated August 16, 1996, was presented to me. 
  
 Heidelberg, this 13th day of November 1997 Notary’s Office 2, Heidelberg 
  

			
	/German original signed/	 	 /Official Seal:
 Notary’s Office,
Heidelberg/

	 Tzschaschel, Notary
	 	 

  

			
		
	 Register entry:
	  	         2 UR 6127 /
97        

	 Free of charge according to § 7, LJKG

	 /German original signed/

	
	 Ruppert, Financial Clerk

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