Document:

EXHIBIT
        4.9

        
        AMENDMENT NO. 
        1

        THIS
        AGREEMENT made the 7th day of March, 2008.

        
        BETWEEN:

        
        ONCOLYTICS BIOTECH INC

        
        (“Oncolytics”)

         

        - and
        -

         

        DOUGLAS
        BALL

        (the
        “Employee”)

        
        WHEREAS Oncolytics and the Employee entered into an Executive Employment
        Agreement dated the 30th day of May, 2007 (the “Employment
        Agreement”);

        
        AND WHEREAS the parties wish to amend the Employment Agreement;

        
        NOW THEREFORE the parties agree as follows:

        
        Section 1 –Amendments

        
        The Employment Agreement is hereby amended by replacing Section 3(1)
        with the following:

        
        “Commencing January 1, 2008, Oncolytics shall pay to the Employee
        a salary of TWO HUNDRED FIFTY-SEVEN THOUSAND FIVE HUNDRED AND SIXTY-SEVEN DOLLARS AND FOUR
        CENTS ($257,567.04) CANADIAN per annum, exclusive of bonuses, benefits and other
        compensation, payable in equal installments of TEN THOUSAND SEVEN HUNDRED THIRTY-ONE
        DOLLARS AND NINETY-SIX CENTS ($10,731.96) CANADIAN on the 15th and last day of
        each month.”

        
        Section 2 - Effective Date

        	
                    
                    (1)

                	
                    
                    This Amending Agreement shall be effective from and after
                    January 1, 2008.

                

        
        (2)          
        In all other respects the parties confirm that the Employment Agreement, as
        amended, shall remain in full force and effect.

        

       

         

        
        IN WITNESS WHEREOF the parties have executed this Agreement as of the day
        and year first above written.

        
        ONCOLYTICS BIOTECH INC.

        
         

        
        Per:    
         /s/ Brad
        Thompson                                                      

        	
                    
                     

                	
                    
                    Brad Thompson

                	
                    
                     

                
	
                    
                     

                	
                    
                    President & CEO

                

        
         

        
         

        
        Per:    
          /s/
        Matt Coffee                                                             

        	
                    
                     

                	
                    
                    Matt Coffey

                	
                    
                     

                
	
                    
                     

                	
                    
                    Chief Scientific Officer

                

        
         

        	
                    
                                                              
                                                    

                	
                    
                     

                
	
                    
                    /s/ Debbie
                    McClusky                                           

                	
                    
                    /s/ Douglas Ball               
                                                               

                
	
                    
                    WITNESS

                	
                	
                    
                    DOUGLAS BALL

                

         

        -2-EXHIBIT
        4.10

        
        AMENDMENT NO. 
        1

        THIS
        AGREEMENT made the 7th day of March, 2008

        
        BETWEEN:

        
        ONCOLYTICS BIOTECH INC.

        
        (“Oncolytics”)

         

        - and
        -

         

        MATTHEW
        COFFEY

        (the
        “Employee”)

        
        WHEREAS Oncolytics and the Employee entered into an Executive Employment
        Agreement dated the 29th day of May, 2007 (the “Employment
        Agreement)”

        
        AND WHEREAS the parties wish to amend the Employment Agreement;

        
        NOW THEREFORE the parties agree as follows:

        
        Section 1 –Amendments

        
        The Employment Agreement is hereby amended by replacing Section 3(1)
        with the following:

        
        “Commencing January 1, 2008, Oncolytics shall pay to the Employee
        a salary of THREE HUNDRED TWENTY-SIX THOUSAND TWO HUNDRED AND TWENTY-FOUR DOLLARS
        ($326,224.00) CANADIAN per annum, exclusive of bonuses, benefits and other compensation,
        payable in equal installments of THIRTEEN THOUSAND FIVE HUNDRED NINETY-TWO DOLLARS AND
        SIXTY-SEVEN CENTS ($13,592.67) CANADIAN on the 15th and last day of each
        month.”

        
        Section 2 - Effective Date

        	
                    
                    (1)

                	
                    
                    This Amending Agreement shall be effective from and after
                    January 1, 2008.

                
	
                (2)   	
                     In all other respects the parties confirm that the
                    Employment Agreement, as amended, shall remain in full force and effect.

                     

                

       

         

         

        
        IN WITNESS WHEREOF the parties have executed this Agreement as of the day
        and year first above written.

        
        ONCOLYTICS BIOTECH INC.

        
         

        
        Per:    
          /s/ Brad
        Thompson                                                    

        	
                    
                     

                	
                    
                    Brad Thompson

                	
                    
                     

                
	
                    
                     

                	
                    
                    President & CEO

                

        
         

        
         

        
        Per:    
          /s/ DA
        Ball                                                                  

        	
                    
                     

                	
                    
                    Doug Ball

                	
                    
                     

                
	
                    
                     

                	
                    
                    Chief Financial Officer

                

         

        	
                    
                                                              
                                                    

                	
                    
                     

                
	
                    
                    /s/ Debbie
                    McClusky                                     

                	
                    
                    /s/ Matthew
                    Coffey                                                             

                
	
                    
                    WITNESS

                	
                	
                    
                    MATTHEW COFFEY

                

        

         

        -2-EXHIBIT
        4.11

        
        AMENDMENT NO. 
        1

        THIS
        AGREEMENT made the 7th day of March, 2008.

        
        BETWEEN:

        
        ONCOLYTICS BIOTECH INC

        
        (“Oncolytics”)

        - and
        –

        BRADLEY
        GEORGE THOMPSON

        (the
        “Employee”)

        
        WHEREAS Oncolytics and the Employee entered into an Executive Employment
        Agreement dated the 6th day of June, 2007 (the “Employment
        Agreement”);

        
        AND WHEREAS the parties wish to amend the Employment Agreement;

        
        NOW THEREFORE the parties agree as follows:

        
        Section 1 –Amendments

        
        The Employment Agreement is hereby amended by replacing Section 3(1)
        with the following:

        
        “Commencing January 1, 2008, Oncolytics shall pay to the Employee
        a salary of FOUR HUNDRED FORTY-FOUR THOUSAND NINE HUNDRED AND NINETY-SIX DOLLARS
        ($444,996.00) CANADIAN per annum, exclusive of bonuses, benefits and other compensation,
        payable in equal installments of EIGHTEEN THOUSAND FIVE HUNDRED FORTY-ONE DOLLARS AND FIFTY
        CENTS ($18,542.50) CANADIAN on the 15th and last day of each month.”

        
        Section 2 - Effective Date

        	
                    
                    (1)

                	
                    
                    This Amending Agreement shall be effective from and after
                    January 1, 2008.

                

        
        (2)          
        In all other respects the parties confirm that the Employment Agreement, as
        amended, shall remain in full force and effect.

         

         

        
        IN WITNESS WHEREOF the parties have executed this Agreement as of the day
        and year first above written.

        
        ONCOLYTICS BIOTECH INC.

        
         

        
        Per:    
          /s/   Fred
        Stewart                      

        	
                    
                     

                	
                    
                    Fred Stewart

                
	
                    
                     

                	
                    
                    Director

                	
                    
                     

                

        
         

        
         

        
        Per:    
          /s/    Doug
        Bell                         

        	
                    
                     

                	
                    
                    Doug Bell

                	
                    
                     

                
	
                    
                     

                	
                    
                    Chief Financial Officer

                

         

         

        	
                    
                    Debbie
                    McClusky                                  

                	
                    
                    /s/ Bradley George
                    Thompson          

                
	
                    
                    WITNESS

                	
                	
                    
                    BRADLEY GEORGE THOMPSON

                

         

        
        -2-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00142-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00142-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00142-of-00352.parquet"}]]