Document:

EX-10.46

 Exhibit 10.46 

Execution Version 
 CONFIDENTIAL TREATMENT
HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 

AMENDED AND RESTATED 

COLLABORATION AND LICENSE AGREEMENT FOR OUTSIDE THE UNITED STATES 

by and between 
 POZEN INC.

 and 
 ASTRAZENECA AB

 November 18, 2013 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION, WHICH
HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
 TABLE OF CONTENTS 

 

									
	 	  	 	  	 	  	Page	 
			
	1.	  	DEFINITIONS	  	 	1	  
			
	2.	  	COLLABORATION GOVERNANCE	  	 	11	  
				
		  	2.1	  	Establishment	  	 	11	  
				
		  	2.2	  	Membership and Procedures	  	 	12	  
				
		  	2.3	  	Decision-Making	  	 	13	  
				
		  	2.4	  	Operating Principles	  	 	14	  
			
	3.	  	[Intentionally Omitted]	  	 	14	  
			
	4.	  	REGULATORY MATTERS	  	 	14	  
				
		  	4.1	  	Responsibilities	  	 	14	  
				
		  	4.2	  	Access to Filings	  	 	15	  
				
		  	4.3	  	Interactions with Regulatory Authorities	  	 	15	  
				
		  	4.4	  	Exchange of Know-How; Information Sharing	  	 	15	  
				
		  	4.5	  	Regulatory Audits	  	 	16	  
				
		  	4.6	  	Adverse Event Reporting	  	 	16	  
				
		  	4.7	  	Records and Reports	  	 	17	  
			
	5.	  	DEVELOPMENT AND COMMERCIALIZATION	  	 	17	  
				
		  	5.1	  	Development and Commercialization	  	 	17	  
				
		  	5.2	  	Regulatory Obligations	  	 	17	  
				
		  	5.3	  	Performance; Diligence	  	 	17	  
				
		  	5.4	  	Commercialization Plan	  	 	18	  
				
		  	5.5	  	Threatened Removal	  	 	18	  
				
		  	5.6	  	Compliance	  	 	18	  

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

									
				
		  	5.7	  	Branding; Trademarks; Domain Names; Trade Dress; Logos	  	 	18	  
				
		  	5.8	  	Commercial Supply	  	 	19	  
			
	6.	  	[Intentionally Omitted]	  	 	19	  
			
	7.	  	LICENSES	  	 	19	  
				
		  	7.1	  	Licensed Technology	  	 	19	  
				
		  	7.2	  	Trademarks	  	 	19	  
				
		  	7.3	  	Sublicenses	  	 	19	  
				
		  	7.4	  	Reservation of Rights; No Implied Licenses	  	 	20	  
				
		  	7.5	  	Restrictive Covenant	  	 	20	  
			
	8.	  	FINANCIAL TERMS	  	 	21	  
				
		  	8.1	  	Development Milestone Payments	  	 	21	  
				
		  	8.2	  	Royalties	  	 	21	  
				
		  	8.3	  	Payments and Sales Reporting	  	 	23	  
				
		  	8.4	  	Records; Audit	  	 	24	  
				
		  	8.5	  	Taxes	  	 	24	  
			
	9.	  	INTELLECTUAL PROPERTY	  	 	25	  
				
		  	9.1	  	Prosecution and Maintenance of Licensed Patents	  	 	25	  
				
		  	9.2	  	Prosecution and Maintenance of Joint Patents	  	 	25	  
				
		  	9.3	  	Ownership of Inventions	  	 	26	  
				
		  	9.4	  	Disclosure	  	 	26	  
				
		  	9.5	  	Cooperation	  	 	26	  
				
		  	9.6	  	Enforcement of Licensed Patents	  	 	26	  
				
		  	9.7	  	Defense of Infringement Claims	  	 	28	  
				
		  	9.8	  	Patent Term Extension and Supplementary Protection Certificate	  	 	28	  
				
		  	9.9	  	Consequence of Patent Challenge	  	 	28	  

  
 -ii- 

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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

									
				
		  	9.10	  	Patent Marking	  	 	28	  
			
	10.	  	REPRESENTATIONS, WARRANTIES; COVENANTS	  	 	29	  
				
		  	10.1	  	Reciprocal Representations and Warranties	  	 	29	  
				
		  	10.2	  	DISCLAIMER OF WARRANTY	  	 	29	  
				
		  	10.3	  	POZEN Non-Compete	  	 	29	  
				
		  	10.4	  	***	  	 	29	  
				
		  	10.5	  	Other Covenants	  	 	29	  
			
	11.	  	CONFIDENTIALITY	  	 	30	  
				
		  	11.1	  	Definition	  	 	30	  
				
		  	11.2	  	Exclusions	  	 	30	  
				
		  	11.3	  	Disclosure and Use Restriction	  	 	30	  
				
		  	11.4	  	Authorized Disclosure	  	 	31	  
				
		  	11.5	  	Use of Name	  	 	32	  
				
		  	11.6	  	Press Releases	  	 	32	  
				
		  	11.7	  	Terms of Agreement to be Maintained in Confidence	  	 	32	  
			
	12.	  	TERM AND TERMINATION	  	 	33	  
				
		  	12.1	  	Amended and Restated Effective Date	  	 	33	  
				
		  	12.2	  	Term	  	 	33	  
				
		  	12.3	  	Termination for Material Breach	  	 	33	  
				
		  	12.4	  	Termination for Cause	  	 	33	  
				
		  	12.5	  	Termination at Will	  	 	34	  
				
		  	12.6	  	Consequences of Expiration and Termination	  	 	34	  
				
		  	12.7	  	Termination for Insolvency	  	 	39	  
				
		  	12.8	  	Effect of Bankruptcy	  	 	39	  
				
		  	12.9	  	Formulation Technology	  	 	39	  

  
 -iii- 

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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

									
				
		  	12.10	  	Survival	  	 	40	  
			
	13.	  	INDEMNIFICATION AND INSURANCE	  	 	40	  
				
		  	13.1	  	Indemnification by POZEN	  	 	40	  
				
		  	13.2	  	Indemnification by AstraZeneca	  	 	40	  
				
		  	13.3	  	Indemnification Procedure	  	 	41	  
				
		  	13.4	  	Expenses	  	 	42	  
				
		  	13.5	  	Insurance	  	 	42	  
			
	14.	  	LIMITATION OF LIABILITY	  	 	43	  
			
	15.	  	MISCELLANEOUS	  	 	43	  
				
		  	15.1	  	Assignment	  	 	43	  
				
		  	15.2	  	Termination of Certain Rights Upon POZEN Change of Corporate Control	  	 	43	  
				
		  	15.3	  	Severability	  	 	44	  
				
		  	15.4	  	Governing Law; Dispute Resolution	  	 	44	  
				
		  	15.5	  	Notices	  	 	45	  
				
		  	15.6	  	Entire Agreement; Modifications	  	 	46	  
				
		  	15.7	  	Relationship of the Parties	  	 	46	  
				
		  	15.8	  	Waiver	  	 	46	  
				
		  	15.9	  	Counterparts	  	 	46	  
				
		  	15.10	  	No Benefit to Third Parties	  	 	46	  
				
		  	15.11	  	Further Assurance	  	 	47	  
				
		  	15.12	  	No Drafting Party	  	 	47	  
				
		  	15.13	  	Construction	  	 	47	  
				
		  	15.14	  	Amendment and Restatement	  	 	47	  

  
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 SCHEDULES 

Schedule 1.46 – Licensed Patents 
 Schedule 4.1.2 – IMS
MAT Data 
 Schedule 8.2.1 – Segregated Royalty Example 

Schedule 8.2.3 – Market Reduction Example 

  
 -v- 

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AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT FOR 

OUTSIDE THE UNITED STATES 

THIS AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT FOR OUTSIDE THE UNITED STATES (the “Agreement”) is made
and entered into as of November 18, 2013 (the “Amended and Restated Execution Date”), by and between POZEN INC., a Delaware corporation having offices at 1414 Raleigh Road, Suite 400, Chapel Hill, North Carolina
(“POZEN”), and ASTRAZENECA AB, a Swedish corporation having an office at SE-431 83, Mölndal, Sweden (“Licensee”). POZEN and Licensee each may be referred to herein individually as a
“Party,” or collectively as the “Parties.” 
 RECITALS 

A. WHEREAS, POZEN and Licensee are parties to that certain Collaboration and License Agreement, dated as of August 1, 2006 and as
amended as of September 6, 2007, October 1, 2008 and September 16, 2013 (as amended, the “Original Agreement”); 

B. WHEREAS, Licensee is in discussions with Horizon Pharma USA, Inc. (“Horizon”) to divest Licensee’s (and its
Affiliates’) rights to Products (as defined below) in the United States (such transaction, the “Divestiture”); and 

C. WHEREAS, to facilitate the proposed Divestiture, Licensee and POZEN desire to amend and restate the terms of the Original Agreement
in two separate agreements: (a) this Agreement, which contains the terms and conditions pursuant to which Licensee will have a license to POZEN’s intellectual property to manufacture, develop and commercialize the Products throughout the
world outside of the United States and Japan and (b) another agreement that contains the terms and conditions pursuant to which Licensee (or its assignee) will have a license to POZEN’s intellectual property to manufacture, develop and
commercialize the Products (as defined below) in the United States (the “U.S. Agreement”). 
 In consideration of the
foregoing premises, the mutual promises and covenants set forth in this Agreement, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, POZEN and Licensee hereby agree as follows: 

AGREEMENT 
  

	1.	DEFINITIONS 

 When used in this Agreement, capitalized terms will have the meanings as
defined below and throughout the Agreement. All financial and accounting terms not otherwise defined in this Agreement, whether capitalized or not, shall have the meanings assigned to them in accordance with generally accepted accounting principles
based on International Accounting Standards/International Financial Reporting Standards as in effect from time to time (“IFRS”). 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 1.1 “Adverse Event” means any adverse medical occurrence in a patient or
clinical investigation subject that is administered a pharmaceutical product, as designated under 21 CFR § 312.32 and any other Applicable Law in the Territory. 

1.2 “Affiliate” means a legal entity that, directly or indirectly, through one or more intermediaries, controls, is
controlled by, or is under common control with an entity. For purposes of this definition only, “control” and, with correlative meanings, the terms “controlled by” and “under common control with” means (a) the
possession, directly or indirectly, of the power to direct the management or policies of a legal entity, whether through the ownership of voting securities or by contract relating to voting rights or corporate governance, or (b) the ownership,
directly or indirectly, of more than 50% of the voting securities or other ownership interest of a legal entity; provided, that if local law restricts foreign ownership, control will be established by direct or indirect ownership of the maximum
ownership percentage that may, under such local law, be owned by foreign interests. 
 1.3 “Amended and Restated Effective
Date” has the meaning set forth in Section 12.1. 
 1.4 “Amended and Restated Execution Date” has the meaning
set forth in the preamble. 
 1.5 “Applicable Law” means the laws, rules, and regulations, including any statutes, rules,
regulations, guidelines, or other requirements that may be in effect from time to time and apply to the activities contemplated by this Agreement in the Territory. 

1.6 “Blocking Patent” means a Patent owned or controlled by a Third Party, one or more Valid Claims of which, in the absence
of a license thereunder, would be infringed by the making, use, sale, offering for sale, or importation of a POZEN Product in the Territory. 

1.7 “Business Combination” means any merger, consolidation, sale of stock, sale or transfer of all or substantially all of
the assets, or other similar transaction to which POZEN is a party, other than (i) any merger, consolidation, or similar transaction following which the individuals and entities who were the beneficial owners of the outstanding voting
securities of POZEN immediately prior to such transaction still beneficially own, directly or indirectly, more than fifty percent (50%) of the voting power of the surviving entity immediately after such transaction; or (ii) any merger,
consolidate, sale of stock, sale or transfer of all or substantially all of the assets, or other similar transaction permitted under Section 15.1 (Assignment). 

1.8 “Business Day” means any day other than (i) Saturday or Sunday or (ii) any other day on which banks in New
York, New York, United States, the United Kingdom or Sweden are permitted or required to be closed. 
 1.9 “Calendar
Quarter” means the respective periods of three (3) consecutive calendar months ending on March 31, June 30, September 30 and December 31. 

1.10 “cGCP” means current good clinical practices as defined in U.S. Regulations 21 CFR §§ 50, 54, 56, 312 and 314,
(or in the case of foreign jurisdictions, comparable regulatory 

  
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standards), the International Conference of Harmonization (ICH) E6 “Good Clinical Practice: Consolidated Guidance,” and in any successor regulation or any official guidance documents
issued by an applicable Regulatory Authority. 
 1.11 “cGLP” means current good laboratory practice standards as defined by
the FDA pursuant to 21 CFR Part 58 (or in the case of foreign jurisdictions, comparable regulatory standards), and in any successor regulation or any official guidance documents issued by a Regulatory Authority. 

1.12 “cGMP” means current good manufacturing practices as contained in 21 CFR Parts 210 and 211 as amended from time to time
and any equivalents contained in regulations in countries outside the U.S. 
 1.13 “Change of Corporate Control” means the
occurrence of either of the following: 
 (a) a Business Combination involving POZEN; or 

(b) the acquisition (whether in a single transaction or series of related transactions) after the Effective Date by a Third Party or
Group of beneficial ownership of *** *** (***%) *** of POZEN’s voting securities. 
 1.14 “Combination Product” means
a Product that includes one or more pharmaceutically active ingredients (in addition to a single Gastroprotective Agent and a single NSAID) and is sold in final form either in a single fixed combination oral solid dosage or as separate doses in a
single package and priced as one item. 
 1.15 “Commercial Launch” means the nationwide commercial sale, promotion and
distribution of POZEN Product in a particular country of the Territory following receipt of Marketing Approval in such country. 
 1.16
“Commercialization” means all activities relating to the manufacture, marketing, promotion, advertising, selling and distribution of Product in any country of the Territory, including pre-Commercial Launch market development activities
conducted in anticipation of Marketing Approval of Product, including, without limitation, seeking pricing and reimbursement approvals for Product, preparing advertising and promotional materials, sales force training, and all interactions and
activities (e.g., dossier preparations and filings) associated with Regulatory Authorities regarding the commercialization of Product and the maintenance of Marketing Approvals. The term “Commercialize” has a correlative meaning.

 1.17 “Commercialization Plan” has the meaning set forth in Section 5.4.1. 

1.18 “Commercialized POZEN Product” has the meaning set forth in Section 12.6.4(a)(ii). 

1.19 “Competing Product” means, with respect to a particular Product being Commercialized by Licensee or any of its
Affiliates or Sublicensees in any country of the Territory, a product being marketed by or on behalf of a Third Party (other than a Sublicensee) in the same country containing at least *** that are *** those in the *** and are ***. 

  
 -3- 

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 1.20 “Controlled” means, with respect to any Know-How, Patent, or other
intellectual property right, the possession of the right, whether directly or indirectly, and whether by ownership, license or otherwise, to assign, or grant a license, sublicense or other right to or under, such Know-How, Patent or right as
provided for herein without violating the terms of any agreement or other arrangements with any Third Party. 
 1.21 “Develop”
or “Development” means all activities relating to pre-clinical and clinical development of a Product and all development activities relating to the preparation and filing of NDAs and obtaining of Marketing Approvals, price and
reimbursement approvals in the Territory, including, without limitation, preparing and conducting pre-clinical testing, toxicology testing, human clinical studies, regulatory affairs. 

1.22 “Diligent Efforts” means, with respect to the Development, Manufacture or Commercialization by Licensee of a product, at
any given time as the case may be, efforts and resources reasonably used by Licensee or its Affiliates (giving due consideration to relevant industry standards) for Licensee’s own products (including internally developed, acquired and
in-licensed products) with similar commercial potential at a similar stage in their lifecycle (assuming continuing development of such product), taking into consideration their safety, tolerability and efficacy, the profitability (taking into
account any payments payable under this Agreement or the Three-Party Agreement), the extent of market exclusivity, patent protection, cost to develop the product, promotable claims, and health economic claims. 

1.23 “Divestiture” has the meaning set forth in the recitals. 

1.24 “Effective Date” means the date on which the Original Agreement became effective pursuant to the terms thereof. 

1.25 “EMEA” means the European Medicines Agency, or any successor agency thereto. 

1.26 “Esomeprazole” means that certain pharmaceutical compound with the name
(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole), including any ***. 
 1.27 “Execution
Date” means August 1, 2006. 
 1.28 “FDA” means the United States Food and Drug Administration, or any
successor agency thereto. 
 1.29 “Field of Use” means the treatment of human diseases and conditions by means of a
pharmaceutical product. 
 1.30 “First Commercial Sale” means, with respect to a Product and on a country-by-country basis
in the Territory, the date on which Licensee or its Affiliate or Sublicensee first sells the Product intended for commercial distribution to any Third Party after receipt of NDA 

  
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Approval of such Product in such country (including, without limitation, sale in an individual state, province or similar sub-national political subdivision in which Marketing Approval may be
received). Sale of a Product for clinical studies, compassionate use, named patient programs, under a treatment IND, test marketing, any clinical studies, or any similar instance where the Product is supplied with or without charge will not
constitute a First Commercial Sale. 
 1.31 “Formulation Technology” means any Know-How Controlled by Licensee in the
Licensee Inventions that are used by Licensee in the manufacture, use, sale or import of the formulation of a Commercialized POZEN Product, and any Patents Controlled by Licensee claiming such Licensee Inventions; provided, that Formulation
Technology will not include any Patents or Know-How to the extent directed to a Gastroprotective Agent, non-steroidal anti-inflammatory, or other drug or chemical agent, or any methods of manufacture or use thereof. 

1.32 “Gastroprotective Agent” means proton pump inhibitors and H2 receptor antagonists for the treatment, prevention or
amelioration of injury to the gastrointestinal tract. 
 1.33 “GPT” means Licensee’s global product team operating
pursuant to Licensee’s instructions for global product teams for the Initial POZEN Product with representatives of Licensee having expertise in the areas of research & development, marketing, regulatory, intellectual property, finance,
toxicology, and other areas. 
 1.34 “GPT Chair” will have the meaning set forth in Section 2.2.1 (GPT). 

1.35 “Group” means a group of related persons or entities deemed a “person” for purposes of Section 13(d) of
the Securities Exchange Act of 1934, as amended. 
 1.36 “Horizon” has the meaning set forth in the recitals. 

1.37 “IND” means an Investigational New Drug Application filed in the United States with the FDA pursuant to 21 CFR
§ 312.20, or the corresponding filing in any country or regulatory jurisdiction other than the United States required for the clinical testing in humans of a pharmaceutical product. 

1.38 “Indirect Tax” means value added taxes, sales taxes, consumption taxes and other similar taxes. 

1.39 “Initial POZEN Product” means the POZEN Product containing non-enteric coated Esomeprazole and enteric-coated Naproxen
that is the subject of NDA #22-511 in the United States. 
 1.40 “Invention” means any invention, discovery or Know-How
that is conceived during the Term in the performance of activities undertaken pursuant to this Agreement by employees, agents, or independent contractors of either Party, its Affiliates or Sublicensees and is Controlled by such Party, Affiliates or
Sublicensees. 
 1.41 “Joint Invention” means any Invention that is conceived jointly by one or more employees, agents, or
independent contractors of Licensee or its Affiliate(s) and one or more employees, agents, or independent contractors of POZEN or its Affiliate(s). 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 1.42 “Joint Patent” means a Patent claiming a Joint Invention. 

1.43 “JSC” has the meaning set forth in Section 2.1.2 (Joint Steering Committee). 

1.44 “Know-How” means any non-public, documented or otherwise recorded or memorialized knowledge, experience, know-how,
technology, information, and data, including formulas and formulations, processes, techniques, unpatented inventions, discoveries, ideas, and developments, test procedures, and results, together with all documents and files embodying the foregoing.

 1.45 “Licensed Know-How” means any Know-How that is necessary or useful for the Development, Manufacture or
Commercialization of Product in the Field of Use in the Territory and that is Controlled by POZEN or any of its Affiliates as of the Effective Date or during the Term. 

1.46 “Licensed Patents” means: (a) the Patents set forth on Schedule 1.46, and any substitutions, divisions,
continuations, continuations-in-part, reissues, renewals, registrations, confirmations, re-examinations, or extensions of such Patents, (b) any Patents in the Territory Controlled by POZEN or any of its Affiliates as of the Effective Date or
during the Term that claim Inventions (including without limitation POZEN’s interest in Joint Inventions), and (c) all other Patents in the Territory Controlled by POZEN or any of its Affiliates as of the Effective Date or during the Term
that are necessary or useful for the Development, Manufacture or Commercialization of a Product in the Territory. Notwithstanding anything in this Section 1.46 to the contrary, Licensed Patents shall not include any Patents Controlled by Pozen
with Valid Claims that do not cover any Product (e.g., any Patents with Valid Claims solely directed to any product containing acetyl salicylic acid). 

1.47 “Licensed Technology” means the Licensed Patents and the Licensed Know-How. 

1.48 “Licensee House Marks” means any trademarks, trade names, domain names, or other names or marks used or registered by
Licensee or its Affiliates at any time during the Term to identify itself. 
 1.49 “Licensee Invention” means any Invention
that is conceived solely by one or more employees, agents, or independent contractors of Licensee or its Affiliate(s). 
 1.50
“Major Ex-U.S. Market” means the following countries: ***, or any country substituted for one of the foregoing countries pursuant to Section 4.1.2 (Outside the U.S.). 

1.51 “Manufacture” means all activities related to the manufacturing of a Product, or any ingredient thereof, in the
Territory, including but not limited to formulation development and process development for the manufacture of a Product, manufacturing supplies for Development, manufacturing for commercial sale, packaging, in-process and finished product testing,
release of product or any component or ingredient thereof, quality assurance activities related to manufacturing and release of product, ongoing stability tests and regulatory activities related to any of the foregoing. “Manufacture” shall
not include any of the above activities with respect to Esomeprazole as an active ingredient. 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 1.52 “Market Reduction” has the meaning set forth in Section 8.2.3
(Rate Step Down for Competing Product Entrants). 
 1.53 “Marketing Approval” means all approvals (including NDA Approvals
and, where available under Applicable Law, pricing and reimbursement approvals in accordance with Applicable Law) of any Regulatory Authority in a country in the Territory, that are necessary or useful to be obtained prior to the manufacture or
Commercialization of a Product in that country. 
 1.54 “Naproxen” means that certain pharmaceutical compound with the
chemical name (S)-6-methoxy-(alpha)-methyl-2-naphthaleneacetic acid, including any *** 
 1.55 “NDA” means a New Drug
Application filed with the FDA as described in 21 CFR § 314, or any corresponding application for Regulatory Authority approval (not including pricing and reimbursement approval) in any country or regulatory jurisdiction other than the
U.S. 
 1.56 “NDA Approval” means receipt of a letter from a Regulatory Authority in the Territory equivalent to the FDA
approving an NDA in the United States. 
 1.57 “Net Sales” means with respect to any Product, the gross amounts recognized
by Licensee, its Sublicensees or its Affiliates from Third Party customers for sales of a Product in the Territory, less the following deductions made by Licensee (to the extent not already taken by Licensee in the Product invoice or in amounts
recognized), its Sublicensees or its Affiliates in arriving at net sales as reported in the Licensee statutory accounts prepared in accordance with IFRS: 

(a) actual credited allowances to such Third Party customers for spoiled, damaged, rejected, recalled, outdated and returned Product
and for retroactive price reductions; 
 (b) the amounts of trade and cash discounts actually granted to Third Party customers, to
the extent such trade and cash discounts are specifically allowed on account of the purchase of such Product; 
 (c) sales taxes,
excise taxes and import/export duties actually due or incurred in connection with the sales of a Product to any Third Party customer; 

(d) allowances, adjustments, reimbursements, discounts, chargebacks and rebates actually granted to Third Party customers (not in
excess of the selling price per unit of such Product); 
 (e) other deductions from gross sales made in arriving at net sales as
reported in the Licensee statutory accounts; and 
 (f) allowance for transportation costs, distribution expenses, special packaging
and related insurance charges in the amount of one and *** *** (***) of the Net Sales calculated after applying the deductions of items (a)-(e) above. 

  
 -7- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Net Sales shall be calculated using Licensee’s internal audited systems used to report such sales as
adjusted for any of items (a)-(f) above not taken into account in such systems. Notwithstanding the foregoing, if Product is sold as a Combination Product, the Net Sales used for the calculation of the
royalties under Section 8.2 (Royalties) shall be determined as follows: 
  

					
	 A
	  	×	  	Net Sales of the Combination Product, where:
	A+B	  	  
		
	A =	  	Standard Sales Price of the ready-for-sale form of the Product if sold separately from the Combination Product in question, in the given country.
		
	B =	  	Standard Sales Price of the ready-for-sale form of a product containing the same amount of the other therapeutically active ingredient(s) that is contained in the Combination Product in question, in the given
country.

 If, in a specific country, (a) the other therapeutically active ingredient(s) in such Combination Product are not
sold separately in such country, Net Sales shall be adjusted by multiplying actual Net Sales of such Combination Product by the fraction A/C, where C is the Standard Sales Price in such country of such Combination Product, and (b) if a Product
contained in the Combination Product is not sold separately, Net Sales shall be calculated by multiplying actual Net Sales of such Combination Product by the fraction (C-B)/C, where B is the Standard Sales Price in such country of the other
therapeutically active ingredient(s) in the Combination Product and C is the Standard Sales Price in such country of the Combination Product. If, in a specific country, both a Product in a Combination Product and a product containing the other
active ingredients in such Combination Product are not sold separately, a market price for such Product and such other active ingredients shall be negotiated by the Parties in good faith based upon the market price of products that are comparable to
such Product or such other active ingredients, as applicable. In each country where the Product in the Combination Product is marketed, the Standard Sales Price of the Product in such Combination Product for purposes of calculating the royalty
payable to POZEN will be no less than *** *** (***%) of the Standard Sales Price of the Product sold outside of such Combination Product in such country. 

In addition, and notwithstanding the foregoing, if a Product is sold together with other goods with or without a separate price for such Product (such group
of products including the Product a “Product Set”), then the Net Sales applicable to the quantity of such Product included in any such transaction will be calculated as follows: 

 

					
	 A
	  	×	  	Net Sales of the Product Set, where:
	A+B	  	  
		
	A =	  	Standard Sales Price of the Product if sold separately from the Product set in question, in the given country.
		
	B =	  	The total of the Standard Sales Prices of all products in the Product Set other than the Product, in the given country.

  
 -8- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 1.58 “Nexium” means AstraZeneca AB’s and its Affiliates’ products
containing Esomeprazole as the sole active ingredient in any presentation form. 
 1.59 “Nexium Business” means AstraZeneca
AB’s and its Affiliates’ development and commercialization activities pertaining to Esomeprazole and Esomeprazole based products. 

1.60 “NSAID” means any non-steroidal anti-inflammatory drug, the primary mechanism of action of which is inhibition of
cyclooxygenase, but excluding acetyl salicylic acid (including salts and derivatives thereof). 
 1.61 “Original Agreement”
has the meaning set forth in the recitals. 
 1.62 “Patent Challenge” has the meaning set forth in Section 9.9. 

1.63 “Patents” means (a) all patents and patent applications in any country or supranational jurisdiction, and
(b) any substitutions, divisions, continuations, continuations-in-part, reissues, renewals, registrations, confirmations, re-examinations, extensions, supplementary protection certificates and the like, and any provisional applications, of any
such patents or patent applications. 
 1.64 “Post-Approval Failure” means: (a) a mandatory withdrawal or recall of a
Product by a Regulatory Authority, or (b) any voluntary withdrawal or recall of a Product in a Major Ex-U.S. Market country that arises from risks associated with a serious adverse health consequence or death reported to a Regulatory Authority
anywhere in the Territory. Notwithstanding the foregoing, any such recall that results primarily from Licensee’s or its Affiliate’s or Sublicensee’s gross negligence, willful misconduct, or failure to comply with Applicable Law in the
Development, Manufacture or Commercialization of a Product in the Territory shall not be considered a Post-Approval Failure for purposes of this Agreement. 

1.65 “POZEN House Marks” means any trademarks, trade names, domain names, or other names or marks used or registered by POZEN
or its Affiliates at any time during the Term to identify itself. 
 1.66 “POZEN Invention” means any Invention that is
conceived solely by one or more employees, agents, or independent contractors of POZEN or its Affiliate(s). 
 1.67 “POZEN
Product” means any product that combines a Gastroprotective Agent and any NSAID in a single fixed combination dosage form, that would, if made, used, sold, offered for sale, had made, imported or exported in the Territory without a license
from POZEN of the Licensed Patents, infringe one or more Valid Claims of the Licensed Patents. 
 1.68 “Product” means:
(a) any POZEN Product, and (b) any other product that combines a Gastroprotective Agent and any NSAID in a single fixed combination oral solid dosage form (with or without one or more additional therapeutically active agents), which

  
 -9- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
product is developed or commercialized by or for, invented or acquired by, or comes under the Control of Licensee or its Affiliates during the Term. For the avoidance of doubt,
“Product” does not include any product containing acetyl salicylic acid (including salts and derivatives thereof). 
 1.69
“Product Labeling” means (a) the full prescribing information for a POZEN Product approved by the applicable Regulatory Authority in the Territory, and (b) all labels and other written, printed or graphic information included
in or placed upon any container, wrapper or package insert used with or for the POZEN Product in the Territory. 
 1.70 “Product
Trademarks” means any trademarks, trade dress (including packaging design), logos, slogans, domain names and designs, whether or not registered in a country or territory, selected and owned by Licensee and used to identify or promote a
POZEN Product in the Territory, but excluding any POZEN House Marks and Licensee House Marks. 
 1.71 “Promotional
Materials” means all sales representative training materials and all written, printed, graphic, electronic, audio or video presentations of information, including, without limitation, journal advertisements, sales visual aids, formulary
binders, reprints, direct mail, direct-to-consumer advertising, internet postings, broadcast advertisements and sales reminder aides (for example, note pads, pens and other such items) intended for use or used by Licensee or its Affiliates in
connection with any promotion of the Initial POZEN Product hereunder in the Territory, but excluding Product Labeling. 
 1.72
“Regulatory Authority” means, in a particular country or jurisdiction, any applicable government regulatory authorities involved in granting approval to market or sell a Product, including any pricing and reimbursement approvals, in
such country or jurisdiction, including, (a) in the United States, the FDA, and any successor government authority having substantially the same function, (b) any non-United States equivalent thereof, and (c) in the EU, the EMEA and
any national regulatory authority in any EU country. 
 1.73 “Regulatory Materials” means regulatory applications,
submissions, notifications, registrations, Marketing Approvals or other submissions made to or with a Regulatory Authority that are necessary or reasonably desirable in order to develop, manufacture, market, sell or otherwise Commercialize the
Initial POZEN Product in a particular country, territory or possession in the Territory. Regulatory Materials include, without limitation, INDs and NDAs, and amendments and supplements for any of the foregoing, and applications for pricing and
reimbursement approvals. 
 1.74 “Royalty Term” has the meaning set forth in Section 8.2.2 (Royalty Term). 

1.75 “Standard Sales Price” means, as reported by IMS (or ACNielsen in the case of over-the-counter products) in the relevant
country in the Territory, the average sales price for the preceding Calendar Quarter for the Product or, in the case of a Combination Product, the average sales price for the applicable presentation and dosage strength of all marketed brands of the
other therapeutically active ingredient(s). As used herein, “presentation” means the method of administration of a pharmaceutical substance into the human body, including, but not limited to, solid oral (including tablets, capsules,
gelcaps, sachets and caplets), other oral (including suspension and solution), parenteral (including intramuscular, subcutaneous and intravenous), transdermal, suppository and intranasal. 

  
 -10- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 1.76 “Sublicense Agreement” means any agreement under which Licensee grants
a Third Party a sublicense, option or other right under the Licensed Technology to make, use, have made, sell, offer for sale, import and export Products in the Field of Use in the Territory. 

1.77 “Sublicensee” means any Third Party that has entered into a Sublicense Agreement. 

1.78 “Term” has the meaning assigned to it in Section 12.2 (Term). 

1.79 “Territory” means all countries of the world, excluding the United States and Japan. 

1.80 “Third Party” means any entity other than POZEN, Licensee, or any of their respective Affiliates. 

1.81 “Third Party Royalties” means upfront, commercialization milestone, royalty and any other similar payments paid by
Licensee or any Licensee Affiliate or Sublicensee to any Third Party in consideration for a license to a Blocking Patent for the Development or Commercialization of POZEN Products in the Territory. 

1.82 “Three-Party Agreement” means that certain letter agreement of even date herewith by and among AstraZeneca AB, POZEN and
Horizon. 
 1.83 “U.S.” or “United States” means the United States of America and its possessions and
territories. 
 1.84 “U.S. Agreement” has the meaning set forth in the recitals. 

1.85 “U.S. Party” has the meaning set forth in Section 7.4.2. 

1.86 “Valid Claim” means any claim of any issued and unexpired patent or a patent application that has not been disclaimed or
held invalid or unenforceable by judgment or decree entered in any judicial proceeding that is not further reviewable through the exhaustion of all permissible applications for rehearing or review by a superior tribunal, or through the expiration of
the time permitted for such applications; provided, that any claim in a pending Patent application that does not issue as a patent claim within *** (***) years after the earliest priority date of such application will not be a “Valid
Claim” until such claim issues as a patent claim. 
  

	2.	COLLABORATION GOVERNANCE 

 2.1 Establishment. 

2.1.1 Global Product Team. The GPT established under the Original Agreement will remain in place and will coordinate and oversee the
Commercialization of the Initial POZEN Product hereunder in the Territory. The purposes of the GPT will be, with respect 

  
 -11- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
to the Initial POZEN Product only, to develop Licensee’s Commercial Launch and marketing plans for the Initial POZEN Product in the Territory. The GPT will have the membership and will
operate by the procedures set forth in Section 2.2 (Membership and Procedures). 
 2.1.2 Joint Steering Committee The joint
steering committee established under the Original Agreement (the “JSC”) shall remain in place to provide strategic guidance to the GPT in decisions pertaining to the Initial POZEN Product in the Territory. The purposes of the JSC
will be to resolve disputes of the GPT. The JSC will have the membership and will operate by the procedures set forth in Section 2.2 (Membership and Procedures). 

2.2 Membership and Procedures. 

2.2.1 GPT. 
 (a)
Membership. In addition to members designated by Licensee, the GPT shall have up to three (3) representatives designated by POZEN, attending, observing and participating in meetings of the GPT at POZEN’s expense, such representatives
having the relevant experience and skill appropriate for service on such team. Attendance of POZEN representatives at GPT meetings shall be agenda-driven, as determined in the sole discretion of Licensee. Licensee shall be entitled to have as many
representatives serve as members of the GPT as it desires. POZEN may replace its representatives on the GPT at any time upon written notice to Licensee. Licensee shall provide POZEN with office space at its facilities for such representatives to
facilitate such participation; provided, that such representatives shall comply with all policies and reasonable restrictions imposed by Licensee and provided to POZEN in writing. Upon prior written consent of Licensee, which consent will not be
unreasonably withheld, a reasonable number of employees, consultants, representatives or advisors of POZEN who are not POZEN’s GPT representatives may attend GPT meetings as observers; provided, that such persons shall comply with all policies
and reasonable restrictions imposed by Licensee and provided to POZEN in writing. 
 (b) Chairpersons. The global product director
designated by Licensee for the Initial POZEN Product will chair the GPT (“GPT Chair”). 
 (c) Meetings. The GPT
will hold meetings when called by the GPT Chair. Meetings may be held in person or by means of telecommunication (telephone, video, or web conference). Face-to-face GPT meetings that require POZEN attendance will be convened on an as-needed basis as
mutually agreed by Licensee and POZEN, but in any event, at least twice per annum. The location of these meetings, will be based on business requirements and determined by mutual agreement between Licensee and POZEN. Following any GPT meeting, the
GPT Chair will be responsible for preparing and issuing minutes of such meeting within fifteen (15) Business Days thereafter. When POZEN has participated in the meeting, such minutes will not be finalized until a representative of the GPT
designated by each Party has reviewed and confirmed the accuracy of such minutes in writing. If a disagreement regarding the accuracy of such minutes cannot be resolved, the minutes will reflect such disagreement. 

  
 -12- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 2.2.2 JSC. 

(a) Membership. Each Party will designate an equal number of representatives, but in no event less than three (3) each, with
appropriate expertise to serve as members of the JSC. Each Party may replace its representatives on the JSC at any time upon written notice to the other Party. 

(b) Co-Chairpersons. One of each Party’s representatives to the JSC will be designated as a co-chairperson. The co-chairpersons
will be responsible for calling meetings and preparing and circulating an agenda in advance of each meeting, and preparing minutes of each meeting. 

(c) Meetings. The JSC will hold meetings at least once every Calendar Quarter, or more frequently as the Parties may agree with at
least two meetings held in person annually. Subject to the preceding sentence, meetings may be held in person at locations to be determined by the mutual agreement of the Parties (a majority of which must be outside the United States) or by means of
telecommunication (telephone, video, or web conferences). Following any JSC meeting, the co-chairpersons will be responsible for preparing and issuing minutes of such meeting within fifteen (15) Business Days thereafter. Such minutes will not
be finalized until a representative of each Party has reviewed and confirmed the accuracy of such minutes in writing. If a disagreement regarding the accuracy of such minutes cannot be resolved, the minutes will reflect such disagreement. 

2.2.3 Limitations of Powers. The GPT and JSC will have only such powers as are specifically delegated to them hereunder and will not be
a substitute for the rights of the Parties. Without limiting the generality of the foregoing, the GPT and JSC will not have any power to amend this Agreement. Any amendment to the terms and conditions of this Agreement may only be implemented
pursuant to Section 15.6 (Entire Agreement; Modifications) below. 
 2.2.4 Expenses. Each Party will be responsible for all of
its own expenses of participating in the GPT and JSC. 
 2.3 Decision-Making. 

2.3.1 GPT Decisions. Subject to the terms of this Section 2.3 (Decision-Making), the GPT will act by decision of the GPT Chair. If
a POZEN representative objects to any decision, then such dispute will be referred to the JSC. 
 2.3.2 JSC Decisions. Subject to the
terms of this Section 2.3 (Decision-Making), the JSC will take action by unanimous vote with each Party having a single vote, irrespective of the number of representatives actually in attendance at a meeting, or by a written resolution signed
by the designated representatives of each of the Parties. If the JSC fails to reach unanimous consent on a particular matter within *** (***) Business Days of POZEN having requested a formal vote on such matter (or any earlier period mutually agreed
to by the Parties if a delay may reasonably be anticipated to have an adverse effect on the Commercialization of the Initial POZEN Product in the Territory), then such dispute will be subject to the resolution procedures described in
Section 2.3.3 (Dispute Resolution) below. 

  
 -13- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 2.3.3 Dispute Resolution. In the event of any dispute in the JSC that is not resolved
pursuant to the terms of Section 2.3.2 (JSC Decisions), either Party may provide written notice of such failure (a “Notice of Disagreement”) to the Chief Executive Officer of the other Party (or his or her designee). The Chief
Executive Officers or designees of each of the Parties will meet at least once in person or by means of live telecommunication (telephone, video, or web conferences) to discuss the matter on which the JSC failed to reach unanimous consent and use
their good faith efforts to resolve the matter within *** (***) Business Days after receipt of the Notice of Disagreement by the applicable Chief Executive Officer of a Party. If any such disagreement is not resolved by the Chief Executive Officers
or designees within such *** (***) Business Day period, then the Chief Executive Officer or designee of Licensee will have the final decision-making authority with respect to disagreement relating to any and all matters. 

2.3.4 Limitation. Notwithstanding this Section 2.3 (Decision-Making), any dispute regarding the interpretation of this Agreement,
the performance or alleged nonperformance of a Party’s obligations under this Agreement, or any alleged breach of this Agreement will be resolved in accordance with the terms of Section 15.4 (Governing Law; Dispute Resolution). 

2.4 Operating Principles. The operating principles adopted by the GPT pursuant to Section 2.4 of the Original Agreement will guide
the conduct of the GPT and clinical subteam meetings. To the extent there is any conflict between such operating principles and the terms and conditions of the Agreement, then the Agreement will control. 

 

	3.	[INTENTIONALLY OMITTED] 

  

	4.	REGULATORY MATTERS 

 4.1 Responsibilities. Licensee will be responsible at
Licensee’s expense, but other than as set forth in this Agreement, shall not be obligated to, prepare and file INDs and NDAs and seek NDA Approvals for the Initial POZEN Product in all countries in the Territory, including preparing all reports
necessary as part of any such IND or NDA. All such INDs and NDAs will be filed in the name of Licensee. Licensee will use Diligent Efforts to obtain Marketing Approval of the Initial POZEN Product in each Major Ex-U.S. Market country. However,
Licensee shall not be required to Develop or Commercialize a POZEN Product in a particular Major Ex-U.S. Market country if it is not commercially reasonable to do so consistent with the exercise of Diligent Efforts and, upon POZEN’s request,
will provide POZEN data supporting such determination. Licensee will have the right in its sole discretion, at any time upon *** (***) Business Days prior written notice to POZEN, to replace any country in the Major Ex-U.S. Market with any other
country or group of countries having a market potential of at least *** percent (***%) of the market potential of the relevant Major Ex-U.S. Market country based on the then-current IMS MAT (Moving Annual Total) Data for sales of *** drugs in such
Major Ex-U.S. Market country as compared to sales of non-steroidal anti-inflammatory drugs in such other country or group of countries, and Licensee’s diligence requirements hereunder shall accordingly transfer from such initial Major Ex-U.S.
Market country to the replacement country or countries. Schedule 4.1.2 sets forth IMS MAT Data that is current as of December 2005. Based on such data, by way of example, if Licensee desired to elect one or more countries to replace the *** as a
Major Ex-U.S. Market country (having $*** in sales), any of the following 

  
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countries or combinations of countries would be acceptable substitutes: (i) ***, with $*** in sales (approx. ***% in sales), (ii) ***, with $*** in sales (approx. ***% in sales), or
(iii) *** and *** combined (approx. ***% in sales). 
 4.2 Access to Filings. Licensee and its Affiliates will have the right of
cross-reference to all NDAs or other filings made by or on behalf of POZEN anywhere in the Territory for the purpose of prosecuting Marketing Approval applications for Products in the Territory, and POZEN and its Affiliates will, or will use
reasonable efforts to cause their licensees to, take all such reasonable actions to allow such cross-reference. 
 4.3 Interactions with
Regulatory Authorities. 
 4.3.1 Consultation. Each Party will consult with the other Party regarding (and provide copies of
materials prior to any submission to a Regulatory Authority and materials after receipt from a Regulatory Authority), and keep such other Party reasonably and regularly informed of, the status of the preparation of all Regulatory Materials in the
Territory, review of such materials by the relevant Regulatory Authority in the Territory, and Marketing Approvals received for the Initial POZEN Product in the Territory. 

4.3.2 Communications. Except as may be required by Applicable Law, only Licensee will communicate regarding POZEN Products, including
the Initial POZEN Product, with any Regulatory Authority having jurisdiction in any country or territory in the Territory; provided, that if POZEN is required by Applicable Law in the Territory to provide to a Regulatory Authority any communication
that relates to ***; provided, that this sentence shall not be construed to obligate POZEN to take any action or make any omission in violation of Applicable Law in the Territory. If POZEN is required to make such a communication by a Regulatory
Authority, then POZEN will ***. 
 4.4 Exchange of Know-How; Information Sharing. As of the Amended and Restated Effective Date, each
Party has provided to the other Party copies of all Know-How in its possession relating to the Initial POZEN Product, including, without limitation, procedures, formulations, manufacturing reports, pre-clinical and clinical protocols and data,
regulatory filings, and toxicology reports with respect to the Initial POZEN Product, including any final versions of any study reports and any drafts outstanding of any study reports, all to the extent reasonably required for a Party to perform its
obligations under this Agreement. Each Party will provide to the other Party copies of any Know-How that comes into its possession on or after the Amended and Restated Effective relating to the Initial POZEN Product, including, without limitation,
procedures, formulations, manufacturing reports, pre-clinical and clinical protocols and data, regulatory filings, and toxicology reports with respect to the Initial POZEN Product, including any final versions of any study reports and any drafts
then-outstanding of any study reports, all to the extent reasonably required for a Party to perform its obligations under this Agreement. In addition, each Party will provide the other Party, in a timely manner, with copies of, and all information
received by it pertaining to, notices, questions, actions and requests from or by Regulatory Authorities with respect to the Initial POZEN Product in the Territory, or the testing, Manufacture, packaging, distribution or facilities in relation
thereto, including any notices of non-compliance with laws in connection with the Initial POZEN Product (e.g., warning letters or other notices of alleged non-compliance), audit notices, notices of initiation by

  
 -15- 

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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
Regulatory Authorities of investigations, inspections, detentions, seizures or injunctions concerning the Initial POZEN Product (or its manufacture, distribution, or facilities connected
thereto), notice of violation letters (i.e., an untitled letter), warning letters, service of process or other inquiries. Except as otherwise set forth in this Agreement or to comply with Applicable Law, ***. 

4.5 Regulatory Audits. If a Regulatory Authority in the Territory desires to conduct an inspection or audit of a Party’s facility,
or a facility under contract with a Party, with regard to a POZEN Product, then such Party will promptly notify the other Party and permit and cooperate with such inspection or audit, and will cause the contract facility to permit and cooperate with
such Regulatory Authority and such other Party during such inspection or audit. Licensee will have the right upon request (which request shall not be unreasonably withheld) to have a representative observe such inspection or audit with respect to a
POZEN facility, or a facility under contract with POZEN. Following receipt of the inspection or audit observations of such Regulatory Authority (a copy of which the audited Party will immediately provide to the other Party), the audited Party will
prepare the response to any such observations, and will provide a copy of such response to the other Party. The audited Party agrees to conform its activities under this Agreement to any commitments made in such a response, except to the extent it
believes in good faith that such commitments violate Applicable Laws. 
 4.6 Adverse Event Reporting. 

4.6.1 If *** *** to make *** *** in an *** and follow *** of such *** as they ***, that this *** to take any ***. 

4.6.2 All AE and SAE reports will be exchanged using either approved study forms, electronic, or computer generated reports agreed upon
by both parties (e.g., CIOMS I form). 
 4.6.3 Subject to Section 4.6.2, Licensee will maintain and will be the
recognized holder of the safety database for AE and SAE reports related to POZEN Products in the Territory. Direct access to this database will not be granted to POZEN. Upon request, all reasonable assistance will be provided by either Party in
responding to safety inquiries in the Territory. 
 4.6.4 Each Party shall keep the other Party informed of notification of any
action by, or notification or other information which it receives (directly or indirectly) from any Regulatory Authority in the Territory which: (i) raises any material concerns regarding the safety or efficacy of the Initial POZEN Product;
(ii) indicates or suggests a potential material liability for either Party to Third Parties arising in connection with the Initial POZEN Product; (iii) is reasonably likely to lead to a “Dear Doctor” letter, recall or market
withdrawal of the Initial POZEN Product; (iv) relates to the Initial POZEN Product, Regulatory Materials, Promotional Materials, samples, package inserts, the indications, labeling, expedited and periodic Adverse Event Reports, medical
inquiries, Initial POZEN Product complaints, this Agreement, or (v) is otherwise important to the Development and/or Commercialization of the Initial POZEN Product. 

  
 -16- 

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 4.7 Records and Reports. Each Party will retain all records required by Applicable Law
to be maintained in connection with such Party’s performance of Development activities under this Agreement. 
  

	5.	DEVELOPMENT AND COMMERCIALIZATION 

 5.1 Development and Commercialization. As
between the Parties, Licensee will be solely responsible for the Development and Commercialization of POZEN Products in the Territory during the Term. 

5.2 Regulatory Obligations . On a country-by-country basis, Licensee will own and maintain all regulatory filings and Marketing
Approvals in the Territory for POZEN Products, including all INDs and NDAs for the Initial POZEN Product in the Territory. As between the Parties, Licensee will be solely responsible for all activities in connection with maintaining Marketing
Approvals required for the Commercialization and manufacture of POZEN Products in the Territory, including communicating and preparing and filing all reports (including Adverse Event reports) with the applicable Regulatory Authorities in the
Territory. 
 5.3 Performance; Diligence. 

5.3.1 Level of Efforts. Upon the grant of Marketing Approval for a POZEN Product in a country of the Major Ex-U.S. Market, Licensee will
use Diligent Efforts to Commercialize a POZEN Product in such country. The foregoing Diligent Efforts requirement will apply only to one POZEN Product in each of the Major Ex-U.S. Market countries, irrespective of the number of POZEN Products
Licensee elects to Develop and Commercialize, and Licensee may elect to fulfill its Diligent Efforts obligation in such countries in respect to any POZEN Product of its choice in the exercise of its reasonable and good faith judgment. Licensee will
have the right to Develop and Commercialize Products during the Term in each country of the Territory, for so long as Licensee is using Diligent Efforts to Commercialize at least one POZEN Product in accordance with this Section 5.3, it being
understood that the Parties intend for Licensee to focus its initial efforts on the Commercialization of the Initial POZEN Product in the Territory. 

5.3.2 Specific Timelines. Licensee will use Diligent Efforts in each country of the Major Ex-U.S. Market to achieve Commercial Launch
within *** (***) days after the date on which Marketing Approval is granted for such Initial POZEN Product in such country; provided, that for any country in which Marketing Approval is granted by Regulatory Authorities ***, then the obligations set
forth in this Section 5.3.2 will apply only to ***; and provided, further, that if Licensee elects to launch the Initial POZEN Product in a particular country or territory following NDA Approval in such country or territory, but before or
without obtaining pricing or reimbursement approval therein, then the *** (***)-day period set forth in this Section 5.3.2 will commence as of the date of such NDA Approval. 

  
 -17- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 5.4 Commercialization Plan. 

5.4.1 Licensee shall prepare and update from time to time an initial commercialization plan summarizing the plan for Commercializing the
Initial POZEN Product in the Major Ex-U.S. Markets (the “Commercialization Plan”) within *** (***) days after the first filing of a Marketing Approval application for the Initial POZEN Product in a country of the Major Ex-U.S.
Markets. The Commercialization Plan as reviewed by the GPT shall describe the overall plan for Commercializing the Initial POZEN Product during the first three years after First Commercial Sale of the Initial POZEN Product in the Major Ex-U.S.
Market. 
 5.4.2 The Commercialization Plan will be in a format consistent with the format of similar plans prepared by Licensee for
its other products. 
 5.5 Threatened Removal. In the event that any governmental authority threatens or initiates any action to
remove any POZEN Product from the market in a country or territory in the Territory, Licensee will promptly notify POZEN of such communication. Any voluntary recall or withdrawal of any POZEN Product in the Territory will be at Licensee’s sole
discretion and expense. Before Licensee initiates a recall or withdrawal in the Territory, the Parties will promptly and in good faith discuss the reasons therefor; provided, that such discussions do not delay the recall or withdrawal. In the event
of any recall or withdrawal of any POZEN Product in the Territory, Licensee will implement any necessary action, with assistance from POZEN as reasonably requested by Licensee. 

5.6 Compliance. Each Party will comply with all Applicable Laws relating to activities performed or to be performed by such Party (or
its Affiliates or contractors) under or in relation to the Commercialization of the Initial POZEN Product in the Territory pursuant to this Agreement. Each Party represents, warrants and covenants to the other Party that, as of the Effective Date
and during the Term, such Party and its Affiliates have adequate policies and procedures in place: (i) to ensure their compliance with such laws; (ii) to bring any non-compliance therewith by any of the foregoing entities to its attention;
and (iii) to promptly remedy any such non-compliance. 
 5.7 Branding; Trademarks; Domain Names; Trade Dress; Logos. 

5.7.1 Responsibilities. Licensee will select all Product Trademarks for use on or in connection with POZEN Products in the Territory,
will be the sole owner of the Product Trademarks in the Territory, and as between the Parties, (a) will be responsible for the filing, prosecution, maintenance and defense of all registrations of the Product Trademarks, and (b) will be
responsible for the payment of any costs relating to filing, prosecution, maintenance and defense of the Product Trademarks, in each case ((a) and (b)), with respect to the Product Trademarks in the Territory. 

5.7.2 Use. Licensee will use the Product Trademarks in connection with the Commercialization of POZEN Products hereunder. The
packaging, Promotional Materials and Product Labeling for POZEN Products will carry the POZEN House Marks only if and to the extent required by Applicable Law in a country or territory. 

5.7.3 Licensee Marks. Licensee reserves all rights in the Product Trademarks and Licensee House Marks. POZEN acknowledges
Licensee’s exclusive right, title and interest in and to such trademarks and acknowledges that nothing herein will be construed to accord to POZEN any rights in such trademarks. POZEN agrees not to use or file any application to register any
trademark or trade name that is confusingly similar to any Product Trademarks or Licensee House Mark. 

  
 -18- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 5.7.4 POZEN Marks. POZEN reserves all rights in the POZEN House Marks not expressly
granted to Licensee in this Agreement. Licensee acknowledges POZEN’s exclusive right, title and interest in and to the POZEN House Marks and acknowledges that nothing herein will be construed to accord to Licensee any rights in such trademarks
except as expressly provided herein. Licensee further acknowledges that its use of the POZEN House Marks will not create in Licensee any right, title or interest in such trademarks, and that all use of such trademarks and the goodwill generated
thereby will inure solely to the benefit of POZEN. Licensee agrees not to use or file any application to register any trademark or trade name that is confusingly similar to any POZEN House Mark. 

5.7.5 Promotional Materials. Licensee will own all right, title and interest in and to any Promotional Materials created by or on
behalf of Licensee (or its Affiliates) relating to POZEN Product in the Territory, but excluding the POZEN House Marks. The GPT will approve a standard template for use of the POZEN House Marks in Promotional Materials, and Licensee will use the
POZEN House Marks in accordance with approved template. 
 5.8 Commercial Supply. Licensee will be solely responsible, at its own
expense, for the Manufacture and supply of Licensee’s entire requirements of supplies of POZEN Product for Commercialization in the Territory. 
  

	6.	[INTENTIONALLY OMITTED] 

  

	7.	LICENSES 

 7.1 Licensed Technology. Subject to the terms and conditions of this
Agreement, POZEN hereby grants to Licensee an exclusive (including with regard to POZEN and its Affiliates), royalty-bearing license, with the right to grant sublicenses as described in Section 7.3 (Sublicenses), under the Licensed Technology
to make, use, have made, sell, offer for sale, import and export Products in the Field of Use in the Territory. For the avoidance of doubt, Licensee shall have no license or other right under the Licensed Technology to make, use, have made, sell,
offer for sale, import, and export any product containing acetyl salicylic acid (including salts and derivatives thereof). 
 7.2
Trademarks. Subject to the terms and conditions set forth in this Agreement, POZEN hereby grants to Licensee a license to use the POZEN House Marks in connection with the Commercialization of POZEN Products in the Field of Use in the Territory.

 7.3 Sublicenses. Licensee may grant a sublicense, option to sublicense, or any other right relating to any Licensed Technology to
any of its Affiliates without the right to grant further sublicense rights to any Third Party. Licensee may grant a sublicense, option to sublicense, or any other right relating to any Licensed Technology to any Third Party solely as provided in
this Section 7.3 (Sublicenses). Licensee may enter into Sublicense Agreements only with POZEN’s prior consent. In order for rights under Licensed Technology to be validly granted to a Sublicensee, the Sublicense Agreement with such
Sublicensee must be consistent 

  
 -19- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
with the following terms and conditions of this Agreement, and will include provisions for the benefit of POZEN corresponding to Section 11 (Confidentiality), 14 (Limitation of Liability),
8.5 (Payments and Sales Reporting), and 8.6 (Records; Audit). Licensee will use Diligent Efforts to (i) procure the performance by any Sublicensee of the terms of each such Sublicense Agreement, and (ii) ensure that any Sublicensee will
comply with the applicable terms and conditions of this Agreement. Licensee hereby guarantees the performance of its Affiliates and Sublicensees that are sublicensed as permitted herein, and the grant of any such sublicense will not relieve Licensee
of its obligations under this Agreement, except to the extent they are satisfactorily performed by such Affiliate or Sublicensee. Notwithstanding the foregoing, Licensee will have the right to sell POZEN Products through any distributors or
sub-distributors of its choice, without the need to obtain prior consent from POZEN, in carrying out its Commercialization activities under this Agreement. 

7.4 Reservation of Rights; No Implied Licenses. 

7.4.1 POZEN retains rights under the Licensed Technology to the extent necessary to perform its obligations under this Agreement. Except
for the rights specifically granted in this Agreement, POZEN reserves all rights to the Licensed Technology. No implied licenses are granted under this Agreement. In particular POZEN is not by this Agreement, by implication or otherwise, granted any
license or other right relating to Esomeprazole, Nexium or the Nexium Business or any Esomeprazole based products or any products containing acetyl salicylic acid (including salts and derivatives thereof), in each case, in the Territory, or any
right in relation to any patent, trademark or other intellectual property right belonging to Licensee or any of its Affiliates, and likewise Licensee is not by this Agreement, by implication or otherwise, granted any license or other right under the
Licensed Technology relating to any products containing acetyl salicylic acid (including salts and derivatives thereof) or any right in relation to any patent, trademark or other intellectual property right belonging to POZEN or any of its
Affiliates, in each case, except as expressly set forth in this Agreement. 
 7.4.2 Licensee understands that POZEN has retained
rights to the Products outside the Territory, and has licensed such rights to a Person under the U.S. Agreement (the “U.S. Party”). 

7.5 Restrictive Covenant. Licensee hereby covenants and agrees not to use any Licensed Technology, nor grant any Third Party any
license or right under any Licensed Technology, other than as expressly permitted in this Agreement. The Parties agree that nothing in this Agreement restricts or prohibits Licensee from by itself or with Third Parties exploiting any products,
including without limitation any products containing non-steroidal anti-inflammatory drugs (e.g., acetyl salicylic acid and esters and derivatives thereof); provided, that Licensee shall not use or practice Licensed Technology in connection
with the development, manufacture or commercialization of any product that is not a Product, and nothing requires Licensee to compensate POZEN if Licensee so exploits such products. 

  
 -20- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

	8.	FINANCIAL TERMS 

 8.1 Development Milestone Payments. The Parties acknowledge and
agree that all Development Milestone Payments payable under Section 8.2 of the Original Agreement have been paid. 
 8.2 Royalties.

 8.2.1 Royalty Rate. Subject to the terms and conditions of this Agreement, Licensee will pay to POZEN royalties based on the
aggregate annual Net Sales of Products sold by Licensee, its Affiliates or Sublicensees, at the rates set forth below: 
 (a) For
Net Sales of Products sold in the Territory: 
 (i) For Net Sales *** ***: 

 

	 	(1)	***% of the portion of aggregate Net Sales of Products during a calendar year that is equal to or less than $***; 

  

	 	(2)	***% of the portion of aggregate Net Sales of Products during a calendar year that is greater than $*** but equal to or less than $***; and 

 

	 	(3)	***% of the portion of aggregate Net Sales of Products during a calendar year that is greater than $***. 

(ii) For Net Sales ***: 
  

	 	(1)	***% of the portion of aggregate Net Sales of Products during a calendar year that is equal to or less than $1***; and 

  

	 	(2)	***% of the portion of aggregate Net Sales of Products during a calendar year that is greater than $***. 

(b) Notwithstanding the foregoing provisions of this Section 8.2.1 (Royalty Rate), if a *** is sold in one or more countries in
the Territory where ***, the total royalties owed for Products shall be determined *** ***, according to the following calculations: 

(i) *** percent (***%) of the total Net Sales of the *** sold in any country in the Territory shall be added to the total Net Sales of
the *** (the resulting amount being the “Segregated Net Sales”), and the applicable royalty rates set forth in Section 8.2.1(a) shall be applied to the Segregated Product Net Sales (the resulting amount being the
“Segregated Royalty Amount”); 

  
 -21- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 (ii) the applicable royalty rates set forth in Section 8.2.1(a) shall be applied
to the remaining *** percent (***%) of the total Net Sales of the *** (the resulting amount being the “Remaining Royalty Amount”); and 

(iii) the amount owed by Licensee shall be equal to the Segregated Royalty Amount plus the Remaining Royalty Amount. 

(iv) If *** are also sold in a country in the Territory where there are at least*** being sold, then the calculations above shall be
applied similarly to each such ***, such that *** percent (***%) of the Net Sales of each *** shall be added to the Segregated Royalty Amount, and the remaining *** percent (***%) of each *** shall be combined only with the remaining *** percent
(***%) of Net Sales of the other additional Products (i.e., ***) that are being sold in other countries in the Territory. The example set forth in Schedule 8.2.1 illustrates the application of this Section 8.2.1(b). 

8.2.2 Royalty Term. Licensee acknowledges that it will continue to enjoy substantial benefit from its license under, and the transfer
to Licensee of certain elements of, the Licensed Technology pursuant to this Agreement (including the Licensed Know-How and the regulatory data to be provided to Licensee pursuant to this Agreement) as well as from Licensee’s own development of
technology derived from the practice of such license and Licensee’s use of such Licensed Technology, even after expiration of all Valid Claims of the Licensed Patents covering the composition of matter, manufacture, use or sale of POZEN Product
in a country in the Territory. Accordingly, subject to the terms of Section 8.2.3 (Rate Step Down for Competing Product Entrants), Licensee’s royalty payment obligations under this Section 8.2 (Royalties) will commence upon First
Commercial Sale of a Product in a particular country in the Territory and will expire on a country-by-country basis upon the later of: (i) expiration of the last-to-expire Valid Claim of the Licensed Patents that, but for the licenses granted
in this Agreement, would be infringed by the sale of such Product in such country, and (ii) ten (10) years after the First Commercial Sale of such Product in such country (such period ending at the later of the periods set forth in clause
(i) and (ii) above, the “Royalty Term”). 
 8.2.3 Rate Step Down For Competing Product Entrants. With
respect to any particular Product and country in the Territory, if in any Calendar Quarter there is a Market Reduction of such Product (based on prescription market data published by IMS Health, Scott-Levin, or such other industry standard source as
the Parties may agree), then the royalty rates which would otherwise apply to Net Sales of such Product in such country during such Calendar Quarter will be reduced to *** percent (***%) of the rates set forth in Section 8.2.1 (Royalty Rate);
provided, that in no event will the *** (resulting in ***; and *** and ***). Such reduced royalty rates will continue in effect, on a Product-by-Product and country-by-country basis, until expiration of the applicable Royalty Term. As used in this
Section 8.2.3, the term “Market Reduction” of a Product in a Calendar Quarter occurs when (i) the cumulative share achieved by Competing Products for such Product commercialized by Third Parties in such ***in such ***and
(ii) ***in such ***to the ***occurred. The example set forth in Schedule 8.2.3 illustrates the application of this Section 8.2.3. 

  
 -22- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 8.2.4 Third Party Payments. If Licensee or a Sublicensee determines that a license to
certain Third Party technology is reasonably necessary for the successful Development, Manufacture or Commercialization of a Product in the Territory, then Licensee will notify POZEN in writing of such determination. The Parties will consult in good
faith regarding the need for such Third Party technology and, subject to POZEN’s consent (not to be unreasonably withheld, conditioned or delayed), Licensee (or Sublicensee, if applicable) will negotiate the terms on which such a Third Party
license would be granted to Licensee and will serve as the primary point of contact with the applicable Third Party licensor following the execution of the license agreement. The royalties required to be paid by Licensee with respect to a Product in
a particular country pursuant to Section 8.2 (Royalties) shall be subject to a reduction by Licensee in an amount equal to *** percent (***%) of the amount of *** that are *** under such *** in such *** for the *** of such ***; provided, that
(i) ***of the ***in such *** and (ii) if such *** is a *** (i.e., if the ***). For clarity and notwithstanding anything to the contrary in this Agreement, Licensee shall be solely responsible for any Third Party payment obligations
it may have to Merck & Co., Inc. or its affiliates, without any offset or deduction. Any amount of Third Party Royalties that may, pursuant to the preceding paragraph be used to reduce royalties due hereunder, in any Calendar Quarter, but
are not so used as a result of the limitation described in clause (i) of this paragraph may be carried over and used for further reduction in any succeeding royalty payment due for such Product. 

8.2.5 ***. 

8.3 Payments and Sales Reporting. 

8.3.1 Sales Reporting. Licensee will provide POZEN, within *** days (***) of the end of each Calendar Quarter, with a report setting
forth, on a country-by-country and Product-by-Product basis, the amount of gross sales of each Product in such country in the Territory, a calculation of Net Sales, the currency conversion rate used and Dollar-equivalent of such Net Sales, and a
calculation of the amount of royalty payment due on such Net Sales, provided that Licensee shall use reasonable efforts to provide such report as soon as practicable to accommodate POZEN’s SEC filing requirements and to provide such reports in
a shorter time period than the periods specified above if Licensee has such reports available for its own internal purposes. If any payment reduction is claimed by Licensee under this Agreement from the full royalty rates set forth in
Section 8.2 (Royalties), then the report will set forth in detail the claimed reduction and the related facts. 
 8.3.2 Payment
Timing. Licensee will make royalty payments to POZEN within *** (***) days of the last day of each Calendar Quarter for which such payments are due under Section 8.2 (Royalties). 

8.3.3 Payment Method. All amounts due hereunder will be paid in United States Dollars by wire transfer in immediately available funds
to the following account, or such other account as may be designated in writing by POZEN: 
  

			
	Receiving bank name:	  	***
	Receiving bank address:	  	***,
                                        
***
	ABA routing number (1):	  	*** (1) - required for domestic transfers
	SWIFT BIC address (2):	  	*** (2) - required for international transfers
	For credit to the account of:	  	POZEN Inc.
	For credit to account number:	  	***

  
 -23- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 8.3.4 Currency Conversion. All payments required under this Article 8 shall be made in
U.S. Dollars. For the purpose of computing the Net Sales of Licensed Products sold in a currency other than U.S. Dollars, such currency shall be converted from local currency to U.S. Dollars by Licensee in accordance with the rates of exchange for
the relevant month for converting such other currency into U.S. Dollars used by Licensee’s internal accounting systems, which are independently audited on an annual basis. 

8.3.5 Late Payments. If a Party does not receive payment of any sum due to it on or before the due date, simple interest will
thereafter accrue on the sum due to such Party until the date of payment at the per annum rate of *** percent (***%) over the then-current *** quoted by Citibank in New York City, or the maximum rate allowable by Applicable Law, whichever is lower.

 8.4 Records; Audit. Licensee will maintain complete and accurate records in sufficient detail to permit POZEN to confirm the
accuracy of the calculation of payments under this Agreement. Upon reasonable prior notice, such records will be available during regular business hours of Licensee for a period of *** (***) calendar years following the year in which such records
were created, for examination at POZEN’s expense, and not more often than once each calendar year, by an independent certified public accountant selected by POZEN and reasonably acceptable to Licensee, for the sole purpose of verifying the
accuracy of the financial reports furnished by Licensee pursuant to this Agreement. Any such auditor will not disclose Licensee’s Confidential Information, except to the extent such disclosure is necessary to verify the accuracy of the
financial reports furnished by Licensee or the amount of payments due by Licensee under this Agreement. Any amounts shown to be owed but unpaid will be paid within *** (***) days from the accountant’s report, plus interest (as set forth in
Section 8.3.5 (Late Payments)) from the original due date. Any amounts determined to be overpaid will be refunded within *** (***) days from the accountant’s report. POZEN will bear the full cost of such audit unless such audit discloses
an underpayment of the amount actually owed during the applicable calendar year of more than *** percent (***%), in which case Licensee will bear the full cost of such audit. 

8.5 Taxes. 
 8.5.1
General. The royalties, milestones and other amounts payable by one Party to the other Party pursuant to this Agreement or the Three-Party Agreement (“Payments”) shall not be reduced on account of any taxes unless required by
Applicable Law. The Party receiving any Payment shall be responsible for paying any and all taxes (other than withholding taxes or deduction of tax at source required by Applicable Law to be paid by the paying Party) levied on account of, or
measured in whole or in part by reference to, any Payments it receives. The paying Party shall deduct or withhold from the Payments any taxes that it is required by Applicable Law to deduct or withhold. Notwithstanding the foregoing, if the Party
receiving payment is entitled under any applicable tax treaty to a reduction of rate of, or the elimination of, applicable withholding tax, it may deliver to the paying Party or the appropriate governmental authority (with the assistance of the
paying Party to the extent that this is reasonably required and is expressly requested in writing) the prescribed forms necessary to reduce the applicable rate of 

  
 -24- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
withholding tax or to relieve the paying Party of its obligation to withhold tax, and the paying Party shall apply the reduced rate of withholding tax, or dispense with withholding tax, as the
case may be, provided that the paying Party has received evidence, in a form satisfactory to the paying Party, of the other Party’s delivery of all applicable forms (and, if necessary, its receipt of appropriate governmental authorization) at
least *** (***) days prior to the time that the Payments are due. If, in accordance with the foregoing, the paying Party withholds any amount, it shall pay to the other Party the balance when due, make timely payment to the proper taxing authority
of the withheld amount, and send to the other Party proof of such payment within *** (***) days following that payment. 
 8.5.2 Indirect
Taxes. Notwithstanding anything contained in Section 8.5.1 (General), this Section 8.5.2 (Indirect Taxes) shall apply with respect to Indirect Taxes. All Payments are exclusive of Indirect Taxes. If any Indirect Taxes are chargeable in
respect of any Payments, the paying Party shall pay the Indirect Taxes at the applicable rate in respect of any such Payments following the receipt of an Indirect Taxes invoice in the appropriate form issued by the Party receiving Payments in
respect of those Payments, such Indirect Taxes to be payable on the due date of the payment of the Payments to which such Indirect Taxes relate. 
  

	9.	INTELLECTUAL PROPERTY 

 9.1 Prosecution and Maintenance of Licensed Patents. POZEN
will be responsible for the preparation, filing, prosecution and maintenance of the Licensed Patents (other than Joint Patents), at its own expense. Notwithstanding the foregoing, ***. POZEN will provide a copy of all proposed filings at least
thirty (30) days in advance of the filing date and will consider in good faith the requests and suggestions of Licensee with respect to filing and prosecuting the Licensed Patents and will keep Licensee promptly informed of progress with regard
to the preparation, filing, prosecution and maintenance of Licensed Patents. In the event that POZEN desires to abandon any Licensed Patent, POZEN will provide reasonable prior written notice to Licensee of such intention to abandon (which notice
will, in any event, be given no later than *** (***) days prior to the next deadline for any action that may be taken with respect to such Licensed Patent with any applicable patent office in the Territory), and Licensee will have the right to
assume responsibility for such Licensed Patent. For clarity, any Patent with Valid Claims solely directed to any product containing acetyl salicylic acid (including salts and derivatives thereof) is not a Licensed Patent; therefore, Licensee will
have no right to assume responsibility for such Patent as provided under this Section 9.1 should Pozen decide to abandon such Patent. 

9.2 Prosecution and Maintenance of Joint Patents. Licensee will be responsible for the preparation, filing, prosecution and maintenance
of Joint Patents, at its own expense. Licensee will provide to POZEN a copy of all proposed filings at least *** (***) days in advance of the filing date and will consider in good faith the requests and suggestions of POZEN with respect to filing
and prosecuting the Joint Patents and will keep POZEN promptly informed of progress with regard to the preparation, filing, prosecution and maintenance of Joint Patents. In the event that Licensee desires to abandon any Joint Patent, Licensee will
provide reasonable prior written notice to POZEN of such intention to abandon (which notice will, in any event, be given no later than *** (***) days prior to the next deadline for any action that may be taken with respect to such Joint Patent with
any applicable patent office in the Territory), and POZEN will have the right to assume responsibility for such Joint Patent. 

  
 -25- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 9.3 Ownership of Inventions. Inventorship of Inventions will be determined in
accordance with the rules of inventorship under United States patent laws. Subject to the licenses granted under this Agreement, as between the Parties, Licensee will own all Licensee Inventions, POZEN will own all POZEN Inventions, and Joint
Inventions will be owned jointly by Licensee and POZEN; provided, however, that during the Term of this Agreement: (i) neither POZEN nor Licensee shall *** other than as expressly provided in this Agreement, including Section 7.1
(Licensed Technology), without the consent of the other Party, which consent shall not be unreasonably withheld, conditioned or delayed, and (ii) neither Party shall assign, pledge, encumber, license or otherwise transfer any of its rights in
any Joint Invention or Joint Patent without the other Party’s prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. Upon any expiration or termination of this Agreement, each Party will have the right
to exploit, license and grant rights to sublicense each such Joint Invention and Joint Patent, without any duty of accounting to the other Party, and each Party hereby consents, and agrees to consent, without payment of any further consideration or
royalty, to the Joint Party’s exploitation and licensing of said Joint Party’s interest in such Joint Invention or Joint Patent to Third Parties; provided, that nothing in this Section 9.3 gives either Party any right or license under
any intellectual property rights Controlled by the other Party other than Joint Inventions and Joint Patents, regardless of whether such rights are necessary in order to exploit the Joint Inventions and Joint Patents pursuant to this
Section 9.3. 
 9.4 Disclosure. Each Party will promptly disclose to the other Party in writing, and will cause its Affiliates,
agents, and independent contractors to so disclose to the other Party, the conception and reduction to practice of any Invention. 
 9.5
Cooperation. Each Party acknowledges the importance of securing and maintaining effective patent protection for the Licensed Technology and Joint Patents. Each Party agrees to cooperate fully in the preparation, filing, prosecution and
maintenance of the Licensed Patents and Joint Patents and in the obtaining and maintenance of any patent extensions, supplementary protection certificates and the like with respect to the Licensed Patents and Joint Patents. Such cooperation
includes, but is not limited to: (a) executing all papers and instruments, or requiring its employees or contractors, to execute such papers and instruments, so as to effectuate the ownership of Inventions set forth in Section 9.3
(Ownership of Inventions), and Patents in the Territory claiming or disclosing such Inventions, and to enable the other Party to apply for and to prosecute patent applications in any country in the Territory; and (b) promptly informing the
other Party of any matters coming to such Party’s attention that may affect the preparation, filing, prosecution or maintenance of any such patent applications. 

9.6 Enforcement of Licensed Patents. 

9.6.1 Infringement by Third Parties. Licensee and POZEN will each, within *** (***) Business Days of learning of any alleged or
threatened infringement of the Licensed Patents or Joint Patents, notify the other Party in writing. *** will have the first right, but not the obligation, to prosecute any such infringement. If *** does not commence an infringement action against
the alleged or threatened infringement (i) within *** (***) days following the 

  
 -26- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
detection of the of alleged infringement, or (ii) *** (*** Business Days before the time limit, if any, set forth in appropriate laws and regulations for filing of such actions, whichever
comes first, then *** will so notify *** promptly, and *** may commence litigation with respect to the alleged or threatened infringement at its own expense. For clarity, any Patent with Valid Claims solely directed to any product containing acetyl
salicylic acid (including salts and derivatives thereof) is not a Licensed Patent; therefore, Licensee will have no right to prosecute any infringement of such Patent under this Section 9.6.1. Notwithstanding anything in this Section 9.6.1
to the contrary, Licensee shall not have the right to prosecute an infringement action under this Section 9.6.1 unless such action involves a Product. 

9.6.2 Challenge by Third Parties. Licensee and POZEN will each notify the other Party in writing within *** (***) Business Days of
learning of any alleged or threatened opposition, reexamination request, action for declaratory judgment, nullity action, interference or other attack upon the validity, title or enforceability of the Licensed Patents or Joint Patents by a Third
Party. *** will have the first right, but not the obligation, to defend any such challenge. If *** does not commence Diligent Efforts to defend against the alleged or threatened challenge (i) within *** (***) days following the detection of the
alleged challenge, or (ii) *** (***) Business Days before the time limit, if any, set forth in appropriate laws and regulations for making a filing in defense of such a challenge, whichever comes first, then *** will so notify *** promptly, and
*** may take action with respect to the alleged or threatened challenge at its own expense. For clarity, any Patent with Valid Claims solely directed to any product containing acetyl salicylic acid (including salts and derivatives thereof) is not a
Licensed Patent; therefore, Licensee will have no right to defend any challenge of such Patent under this Section 9.6.2. 
 9.6.3
Cooperation. In the event a Party brings an infringement action pursuant to Section 9.6.1 (Infringement by Third Parties), the other Party will cooperate fully, including, if required to bring such action, the furnishing of a power of
attorney or to join such action as a necessary party, executing all papers and instruments, or requiring its employees or contractor, to execute such papers and instruments, so as to successfully prosecute any such actions. Neither Party will have
the right to settle any patent infringement litigation under this Section 9.6.3 (Cooperation) in a manner that could be reasonably expected to diminish the rights or interest of the other Party, or adversely effect the validity or
enforceability of such other Party’s Patents, without the express written consent of such other Party. The Party commencing the litigation will provide the other Party with copies of all pleadings and other documents filed with the court and
will consider reasonable input from the other Party during the course of the proceedings. 
 9.6.4 Recovery. Except as otherwise
agreed by the Parties in connection with a cost sharing arrangement, any recovery realized as a result of such litigation described in Section 9.6.1 (Infringement by Third Parties) (whether by way of settlement or otherwise) will be first
allocated to reimbursement of unreimbursed legal fees and all litigation expenses incurred by the Party initiating the proceeding, then toward reimbursement of any of unreimbursed legal fees and all litigation expenses of the other Party, and then
the remainder will be divided between the Parties as follows: (a) settlements, damages or other monetary awards recovered pursuant to a suit, action or proceeding brought by *** will be *** and subject to the *** set forth in Section ***; and
(b) settlements, damages or other monetary awards recovered pursuant to a suit, action or proceeding brought by *** will be ***. 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 9.7 Defense of Infringement Claims. If the manufacture, sale or use of a POZEN Product
pursuant to this Agreement results in any claim, suit, or proceeding by a Third Party alleging that such activities infringe a Third Party patent, or if a Third Party threatens such a claim, suit or proceeding, each Party will promptly notify the
other Party thereof. *** (or its ***) will have the exclusive right to defend and control the defense of any such claim, suit or proceeding at its own expense, using counsel of its own choice; provided, that if any such proceedings involve
matters relating to the validity or enforceability of the Licensed Patents or Joint Patents, then the provisions of Section 9.6.3 (Cooperation) above shall apply. In any claim, suit or proceeding under this Section 9.7, *** will keep ***
reasonably informed of all material developments in connection with any such claim, suit, or proceeding; provided, that if *** is named as a defendant in any such claim, suit or proceeding, that *** shall have the right to participate in the
defense using counsel of its choice at its own expense. In any claim, suit or proceeding under this Section 9.7, *** agrees to provide *** with copies of all pleadings filed in such action and to allow *** reasonable opportunity to participate
in the defense of the claims. 
 9.8 Patent Term Extension and Supplementary Protection Certificate. Upon receiving Marketing
Approval for a POZEN Product, the Parties agree to coordinate the application for any patent term extension or supplementary protection certificates that may be available. The primary responsibility of applying for any extension or supplementary
protection certificate will be the Party having the right to make the application under the Applicable Law. The Party responsible for filing the application will keep the other Party fully informed of its efforts to obtain such extension or
supplementary protection certificate. Each Party will provide prompt and reasonable assistance, without additional compensation, to obtain such patent extension or supplementary protection certificate. The Party filing such request will pay all
expenses in regard to obtaining the extension or supplementary protection certificate. 
 9.9 Consequence of Patent Challenge. If
Licensee or its Affiliates challenge the validity or enforceability of any of the Licensed Patents by any opposition, reexamination request, action for declaratory judgment, nullity action, interference or other attack upon the validity, title or
enforceability thereof before any governmental agency, court or other similar adjudicative forum (any such proceeding, a “Patent Challenge”), such Patent Challenge shall give POZEN the right to terminate this Agreement as provided
in Section 12.3 (Termination for Material Breach) or to terminate all licenses granted under any of the Licensed Patents subject to such Patent Challenge; provided, that the foregoing provisions of this Section 9.9 (Consequence of Patent
Challenge) will not apply in the event that, prior to such Patent Challenge, POZEN or any of its licensees or assignees initiates or threatens litigation against, or makes claims or assertions against, Licensee or its Affiliates, Sublicensees or
Third Party contractors, that allege that any of such parties infringe a Licensed Patent. 
 9.10 Patent Marking. Any POZEN Product
marketed and sold by Licensee under this Agreement will be marked with appropriate patent numbers or indicia as permitted or required by law. The Parties agree to cooperate to reach a decision on the marking requirements. 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

	10.	REPRESENTATIONS, WARRANTIES; COVENANTS 

 10.1 Reciprocal Representations and
Warranties. Each Party represents and warrants to the other Party that: (a) this Agreement is a legal and valid obligation binding upon its execution and enforceable against it in accordance with its terms and conditions; and (b) the
execution, delivery and performance of this Agreement by such Party has been duly authorized by all necessary corporate action, and the person executing this Agreement on behalf of such Party has been duly authorized to do so by all requisite
corporate actions. 
 10.2 DISCLAIMER OF WARRANTY. EXCEPT FOR THE EXPRESS REPRESENTATIONS AND WARRANTIES SET FORTH IN SECTION 10.1
(RECIPROCAL REPRESENTATIONS AND WARRANTIES), EACH PARTY MAKES NO REPRESENTATIONS AND GRANTS NO WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND POZEN AND LICENSEE EACH SPECIFICALLY DISCLAIMS ANY
OTHER WARRANTIES, WHETHER WRITTEN OR ORAL, OR EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF QUALITY OR MERCHANTABILITY, OR ANY WARRANTY AS TO THE VALIDITY OR ENFORCEABILITY OF ANY PATENTS OR THE NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS
OF THIRD PARTIES. 
 10.3 POZEN Non-Compete. POZEN covenants that it will not at any time prior to the expiration of the Royalty
Term, and will ensure that its Affiliates do not, directly or indirectly, develop or commercialize or license any Third Party to develop or commercialize any product having a *** in the Territory; provided, that after *** (***) years following the
Commercial Launch of a POZEN Product in the European Union, POZEN and its Affiliates shall be free, in the European Union only, to Develop, Commercialize or license a Third Party to Develop or Commercialize a product having a *** in *** with an ***.
Without limiting Licensee’s rights under this Agreement or otherwise, in case of any breach of this Section 10.3 (POZEN Non-Compete), Licensee will notify POZEN and, if such breach is not cured by POZEN within *** (***) days after receipt
of such notice, ***. 
 10.4 ***. 

10.5 Other Covenants. 

10.5.1 POZEN will not enter into any agreement, whether written or oral with respect to, or otherwise assign, transfer, license, convey
or otherwise encumber its rights, title or interest in the Licensed Technology (including by granting any covenant not to sue with respect thereto) to any Person in a manner that is inconsistent with the rights and licenses granted to Licensee under
this Agreement. 
 10.5.2 Each Party will obtain from each of its Affiliates, sublicensees, employees and agents and from the
employees and agents of its Affiliates, sublicensees and agents who are or will be involved in the Development of the POZEN Products or of the Licensed Technology, rights to any and all inventions, information, and intellectual property rights
conceived in the course of performance of this Agreement, necessary to enable such Party to grant the licenses and other rights granted to the other Party under this Agreement. 

  
 -29- 

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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

	11.	CONFIDENTIALITY. 

 11.1 Definition. “Confidential Information” means
information, including scientific and manufacturing information and plans, marketing and business plans, and financial and personnel matters relating to a Party or its present or future products, sales, suppliers, customers, employees, investors or
business, communicated by a Party (a “Disclosing Party”) to the other Party (a “Receiving Party”) (a) after the Amended and Restated Effective Date in connection with this Agreement or the performance of its
obligations hereunder or (b) in connection with (i) that certain confidentiality agreement between the Parties dated as of March 27, 2006, (ii) that certain confidentiality agreement between the Parties dated as of June 15,
2006 or (iii) the Original Agreement, in each case ((i), (ii) and (iii)), except to the extent that such information relates exclusively to the exploitation of Products outside the Territory. Notwithstanding the foregoing or any other
provision of this Agreement to the contrary, during the Term, the Licensed Know-How will be deemed to be the Confidential Information of both Parties. 

11.2 Exclusions. Notwithstanding the foregoing, information of a Disclosing Party will not be deemed Confidential Information with
respect to a Receiving Party for purposes of this Agreement to the extent the Receiving Party can demonstrate by competent evidence that such information: 

11.2.1 was already known to the Receiving Party or its Affiliates, as evidenced by their written records, other than under an
obligation of confidentiality or non-use, at the time of disclosure to the Receiving Party; 
 11.2.2 was generally available or was
otherwise part of the public domain at the time of its disclosure to the Receiving Party; 
 11.2.3 became generally available or
otherwise became part of the public domain after its disclosure to the Receiving Party, through no fault of or breach of its obligations under this Section 11 (Confidentiality) by the Receiving Party; 

11.2.4 was disclosed to the Receiving Party or any of its Affiliates, other than under an obligation of confidentiality or non-use, by
a Third Party who had no obligation to the Party that controls such information and know-how not to disclose such information or know-how to others; or 

11.2.5 was independently discovered or developed by the Receiving Party or its Affiliates, as evidenced by their written records,
without the use of, and by personnel who had no access to, Confidential Information belonging to the Party that controls such information and know-how. 

11.3 Disclosure and Use Restriction. Except to the extent expressly authorized by this Agreement or otherwise agreed in writing by the
parties, the parties agree that, during the Term and for *** (***) years thereafter, the Receiving Party will keep confidential and will not publish or otherwise disclose and will not use for any purpose other than as expressly provided for in this
Agreement any Confidential Information of the Disclosing Party. The Receiving Party may use such Confidential Information only to the extent required to accomplish the purposes of this Agreement or in connection with the exercise of its rights
hereunder. The Receiving Party will use at least the same standard of care as it uses to protect proprietary or confidential 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
information of its own to ensure that its employees, agents, consultants and other representatives do not disclose or make any unauthorized use of the Confidential Information. The Receiving
Party will promptly notify the other upon discovery of any unauthorized use or disclosure of the Confidential Information. 
 11.4
Authorized Disclosure. A Receiving Party may disclose Confidential Information of a Disclosing Party to the extent that such disclosure is: 

11.4.1 made in response to a valid order of a court of competent jurisdiction or other governmental or regulatory body of competent
jurisdiction; provided, however, that such Receiving Party will have given notice to the Disclosing Party within *** (***) Business Days of receipt of such order and given the Disclosing Party a reasonable opportunity to quash such order and
to obtain a protective order requiring that the Confidential Information and documents that are the subject of such order be held in confidence by such court or governmental or regulatory body or, if disclosed, be used only for the purposes for
which the order was issued; and provided, further, that if a disclosure order is not quashed or a protective order is not obtained, the Confidential Information disclosed in response to such court or governmental order will be limited to that
information which is legally required to be disclosed in response to such court or governmental order; 
 11.4.2 otherwise required
by law; provided, that the Disclosing Party will provide the Receiving Party with notice of such disclosure at least *** (***) days in advance thereof to the extent practicable and take reasonable steps as requested by the Disclosing Party to
protect the Disclosing Party’s rights; 
 11.4.3 made by a Receiving Party, in connection with the performance of this
Agreement, (a) to Affiliates, employees, consultants, representatives or agents, each of whom prior to disclosure must be bound by obligations of confidentiality and non-use at least equivalent in scope to those set forth in this
Section 11 (Confidentiality) or (b) to Regulatory Authorities in the Territory (provided, that in the case of disclosures to Regulatory Authorities, the Receiving Party will, to the extent practicable, provide the Disclosing Party
with notice of such disclosure at least *** (***) days in advance thereof and will reasonably consider any comments received from the Disclosing Party); 

11.4.4 made by a Receiving Party to existing or potential acquirers or merger candidates; potential sublicensees or collaborators (to
the extent contemplated hereunder); investment bankers; existing or potential investors, venture capital firms or other financial institutions or investors for purposes of obtaining financing; or Affiliates, each of whom prior to disclosure must be
bound by obligations of confidentiality and non-use at least equivalent in scope to those set forth in this Section 11 (Confidentiality); or 

11.4.5 made by the Receiving Party with the prior written consent of the Disclosing Party. 

11.4.6 POZEN shall not make any public statement in the Territory regarding Esomeprazole or Nexium that is not consistent with any
written document agreed to by POZEN and Licensee under the Original Agreement specifying the statements regarding Esomeprazole 

  
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and Nexium that POZEN’s representatives are permitted to make in response to appropriate questions from POZEN investors relating to POZEN Products in the Territory, which document shall be
updated by the Parties by mutual agreement as appropriate from time to time, such agreement not to be unreasonably withheld, conditioned or delayed. 

11.5 Use of Name. Neither Party may make public use of the other Party’s name except (a) in connection with announcements and
other disclosures relating to this Agreement and the activities contemplated hereby as permitted in Section 11.6 (Press Releases), (b) as required by Applicable Law, and (c) otherwise as agreed in writing by such other Party. 

11.6 Press Releases. 

11.6.1 On or after the Execution Date of this Agreement at a mutually agreed time, each Party will issue a mutually agreed press release
announcing the existence of this Agreement each in the form and substance to be mutually agreed upon in advance. For subsequent press releases and other written public disclosures relating to this Agreement or the Parties’ relationship
hereunder (each, a “Public Disclosure”), each Party will use reasonable efforts to submit to the other Party a draft of such Public Disclosures for review and comment by the other Party at least *** (***) Business Days prior to the
date on which such Party plans to release such Public Disclosure, and in any event will submit such drafts at least *** prior to the release of such Public Disclosure, and will review and consider in good faith any comments provided in response.
Notwithstanding the foregoing, subject to Section ***. 
 11.6.2 If a Party is unable to comply with the foregoing *** notice
requirement because of a legal obligation or stock exchange requirement to make more rapid disclosure, such Party will not be in breach of this Agreement but will in that case provide notice as promptly as practicable under the circumstances. 

11.6.3 A Party may publicly disclose, without regard to the preceding requirements of this Section 11.6 (Press Releases),
information that was previously disclosed in a Public Disclosure that was in compliance with such requirements. 
 11.7 Terms of
Agreement to be Maintained in Confidence. The Parties agree that the terms of this Agreement are confidential and will not be disclosed by either Party to any Third Party (except to a Party’s professional advisors, including without
limitation accountants, financial advisors, and attorneys) without prior written permission of the other Party; provided, however, that (a) either Party may make any filings of this Agreement required by law or regulation in any country
so long as such Party uses its reasonable efforts to obtain confidential treatment for portions of this Agreement as available, consults with the other Party, and permits the other Party to participate, to the greatest extent practicable, in seeking
a protective order or other confidential treatment; (b) either Party may disclose this Agreement on a confidential basis to existing or potential Third Party investors, lenders or acquirors or, in the case of Licensee, to existing or potential
Sublicensees, in each case in connection with due diligence or similar investigations; and (c) a Party may publicly disclose, without regard to the preceding requirements of this Section 11.7, information that was previously disclosed in
compliance with such requirements. 

  
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	12.	TERM AND TERMINATION 

 12.1 Amended and Restated Effective Date. This Agreement
(other than this Section 12.1, which is binding and effective as of the Amended and Restated Execution Date), shall not become effective unless and until the closing of a Divestiture occurs (the date of such closing, the “Amended and
Restated Effective Date”), and upon the Amended and Restated Effective Date this Agreement and all of its terms and provisions shall be automatically effective and binding on both Parties. The Original Agreement shall not be amended and
restated or otherwise superseded by this Agreement until the Amended and Restated Effective Date. If the Amended and Restated Effective Date has not occurred by December 31, 2013, then this Agreement, including this Section 12.1, shall
terminate and be of no further force and effect. For clarity, such termination will not give rise to any of the effects or consequences set forth in Section 12.6. 

12.2 Term. The term of this Agreement will commence as of the Effective Date and, unless earlier terminated in accordance with this
Section 12 (Term and Termination), will expire upon the expiration of the Royalty Term for all POZEN Products in all countries in the Territory (the “Term”). 

12.3 Termination for Material Breach. In the event that either Party (the “Breaching Party”) shall be in material
default of any of its material obligations under this Agreement, in addition to any other right and remedy the other Party (the “Non-Breaching Party”) may have, the Non-Breaching Party may terminate this Agreement in its entirety or
with respect to the country or countries in the Territory to which such material default applies by *** (***) days prior written notice (the “Notice Period”) to the Breaching Party, specifying the breach and its claim of right to
terminate; provided, that the termination shall not become effective at the end of the Notice Period if the Breaching Party cures the breach complained about during the Notice Period (or, if such default cannot be cured within such Notice Period, if
the Breaching Party commences actions to cure such default within the Notice Period and thereafter diligently continues such actions); provided, further, that in the event that Licensee is the Party in material default and the default is with
respect to Licensee’s failure to use Diligent Efforts as required under this Agreement with respect to the Initial POZEN Products in a particular Major Ex-U.S. Market Country, POZEN shall have the right to terminate this Agreement only with
respect to such country and not in its entirety. It is understood that termination pursuant to this Section 12.3 (Termination for Material Breach) shall be a remedy of last resort and may be invoked only in the case where the breach cannot be
reasonably remedied by the payment of money damages or other remedy under applicable law. If either Party initiates a dispute resolution procedure as permitted under this Agreement prior to the end of the Notice Period to resolve the dispute for
which termination is being sought and is diligently pursuing such procedure, including any litigation following therefrom, the termination shall become effective only if and when such dispute is finally resolved through such dispute resolution
procedure. This Section 12.3 (Termination for Material Breach) defines exclusively the Parties’ right to terminate in case of any material breach of this Agreement. 

12.4 Termination for Cause. If a Post-Approval Failure occurs anywhere in the Territory, Licensee may, at its option, terminate the
Agreement either in its entirety, or in the country where the Post-Termination Failure occurred only, or on a country-by-country basis with respect to one or more countries of the Territory; provided, that written notice of termination must be
delivered to POZEN within *** (***) days following such Post-Approval Failure. 

  
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 12.5 Termination at Will. Licensee may terminate this Agreement in its entirety at any
time at will upon *** (***) days’ prior written notice to POZEN. 
 12.6 Consequences of Expiration and Termination. 

12.6.1 Effect of Expiration. Upon expiration (but not earlier termination) of the Term pursuant to Section 12.2 (Term), Licensee
will have a non exclusive, irrevocable, perpetual, fully-paid license, with the right to sublicense, under the Licensed Technology to research, develop, make, use, sell, offer for sale, and import the POZEN Product in the Field of Use in the
Territory. 
 12.6.2 Effect of Termination Generally. The use by either party hereto of a termination right provided for under this
Agreement and in accordance with this Agreement shall not give rise to the payment of damages or any other form of compensation or relief to the other party with respect thereto. Subject to the preceding sentence, termination of this Agreement shall
not preclude either party from claiming any other damages, compensation or relief that it may be entitled to upon such termination or for any breach of this Agreement. 

12.6.3 Effect of Termination for Cause or for Material Breach. If either Party terminates this Agreement pursuant to Section 12.3
(Termination for Material Breach) in its entirety or with respect to a particular country, or if either Party terminates this Agreement pursuant to Section 12.4 (Termination for Cause) in its entirety or with respect to a particular country or
group of countries, all rights and licenses granted by POZEN to Licensee and all obligations of Licensee and POZEN under this Agreement will terminate immediately with respect to all countries in which this Agreement has been terminated. 

12.6.4 Effect of Termination At Will. Upon termination of this Agreement pursuant to Section 12.5 (Termination at Will), all
rights and licenses granted by POZEN to Licensee under this Agreement will terminate immediately. In addition, the following provisions will apply: 

(a) Licensee shall, at its sole option, do one of the following (which, in either case, shall be the sole and exclusive consideration
owed to POZEN on account of such termination): 
 (i) pay POZEN an amount equal to $***; or 

(ii) only if Licensee is able to convey to POZEN materially the same freedom to operate with respect to the Manufacture and
Commercialization of any POZEN Product Commercialized by Licensee at the time of such termination (the “Commercialized POZEN Product”) as Licensee enjoyed immediately prior to such termination in the Territory, perform the actions
described in paragraphs (1) through (10) below: 
  

	 	(1)	To the extent permitted by Applicable Law, Licensee shall transfer and assign to POZEN all Regulatory Materials and Marketing Approvals that are Controlled by Licensee for Commercialized POZEN Product in the
Territory. 

  
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	 	(2)	Licensee shall transfer to POZEN or its designee the management and continued performance of any clinical trials for the Commercialized POZEN Product ongoing as of the effective date of such termination, which
clinical trials will be conducted at POZEN’s expense after such transfer. 

  

	 	(3)	Upon POZEN’s request, Licensee shall transfer to POZEN at Licensee’s full manufacturing cost any stock of finished Commercialized POZEN Product held by Licensee or its Affiliates for use in the
Territory. 

  

	 	(4)	Licensee shall for a reasonable period of time, provide such assistance, at no cost to POZEN, to transfer or transition to POZEN all other technology or know-how Controlled by Licensee, or then-existing
commercial arrangements (to the extent transferable in accordance with the terms and conditions of such arrangements) as may be reasonably necessary or useful for POZEN to commence or continue developing, manufacturing, or Commercializing the
Commercialized POZEN Products in the Territory, to the extent Licensee is then performing or having performed such activities (including without limitation transferring, upon request of POZEN, any agreements or arrangements with Third Party
suppliers or vendors to supply or sell the Commercialized POZEN Product, to the extent such agreements or arrangements are transferable in accordance with their terms and conditions). 

 

	 	(5)	 Licensee shall transfer to POZEN or its designee any then-current manufacturing processes for the Commercialized POZEN Product. In addition, to
the extent that Licensee or its Affiliate is then manufacturing Commercialized POZEN Product, Licensee will negotiate in good faith a supply agreement for the Commercialized POZEN Product on commercially reasonable terms under which

  
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Licensee will continue to manufacture, and will supply to POZEN, at a cost that equals *** percent (***%) of Licensee’s actual manufacturing costs (calculated in accordance with
Licensee’s standard cost and accounting policies), POZEN’s requirements of POZEN Product for the Territory, for a period of up to *** (***) years, in order to permit POZEN to establish sufficient manufacturing capacity for Commercialized
POZEN Product; provided, however, that POZEN shall use commercially reasonable efforts to transition manufacture of the Commercialized POZEN Product to a Third Party as soon as reasonably practicable. 

 

	 	(6)	 The supply agreement entered into between POZEN and Licensee as contemplated by paragraph (5) above shall provide that at all times that
Licensee is supplying POZEN Product under such agreement, allow a delegation consisting of a reasonable number of representatives of POZEN, no more than once per calendar year, to inspect and audit any Licensee facility where such Commercialized
POZEN Product, including its active pharmaceutical ingredients (except for ***), is Manufactured, and the documentation generated in connection with the Manufacture and testing of such Commercialized POZEN Product for the purpose of verifying that
the POZEN Product is being manufactured in accordance with applicable Laws. The supply agreement entered into between POZEN and Licensee as contemplated by paragraph (5) above shall provide that such inspections will take place during regular
business hours and after at least thirty (30) days prior notice to Licensee. POZEN will discuss the results of any inspection with Licensee. Any inspection by or on behalf of POZEN, if it occurs, does not relieve Licensee of its obligation to
comply with all Applicable Laws and does not constitute a waiver of any right otherwise available to POZEN. POZEN will treat all information subject to review under this paragraph in accordance with the provisions of Section 11
(Confidentiality) and will cause any Third Party representative retained by POZEN (and reasonably acceptable to Licensee) to enter into a reasonably 

  
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acceptable confidentiality agreement with Licensee obligating such auditor to maintain all such information in confidence pursuant to such confidentiality agreement. 

 

	 	(7)	The supply agreement entered into between POZEN and Licensee as contemplated by paragraph (5) above shall provide that, during any period when Licensee is supplying Commercialized POZEN Product under such
agreement, Licensee shall notify POZEN promptly following notice from the FDA or any Regulatory Authority of a visit to any Licensee facility where such Commercialized POZEN Product is Manufactured. The supply agreement entered into between POZEN
and Licensee as contemplated by paragraph (5) above shall provide that Licensee will inform POZEN of the results of any inspection by a Regulatory Authority that does or could reasonably be expected to affect the Manufacture of such
Commercialized POZEN Product. Licensee will promptly provide POZEN with copies of notifications from any Regulatory Authority (including, without limitation, any Form No. 483 notification, Enforcement Inspection Reports, Notice of Adverse
Finding, etc.). POZEN will treat all information subject to review under this paragraph in accordance with the provisions of Section 11 (Confidentiality) and will cause any Third Party auditor retained by POZEN (and reasonably acceptable to
Licensee) to enter into a reasonably acceptable confidentiality agreement with Licensee obligating such auditor to maintain all such information in confidence pursuant to such confidentiality agreement. 

 

	 	(8)	During any period when Licensee is supplying POZEN Product under the supply agreement between POZEN and Licensee contemplated by paragraph (5) above, or POZEN is using such Commercialized POZEN Product,
Licensee shall grant to POZEN rights of reference (including by providing a letter of authorization to the applicable Regulatory Authorities) to any Licensee IND or NDA pertaining to Esomeprazole. Upon the expiration of such right, POZEN will send
written notice to such effect to the applicable Regulatory Authority. 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

	 	(9)	Licensee shall grant to POZEN an exclusive, royalty-bearing license, with the right upon prior written notice to Licensee to sublicense through multiple tiers, under any Patents Controlled by Licensee that would
be infringed by the manufacture, use or sale of Commercialized POZEN Products, solely to make, have made, use, sell, offer for sale, have sold, import, and export such Commercialized POZEN Products in the Field of Use in the Territory. In
consideration of the foregoing license, POZEN shall pay to Licensee royalties on net sales of Commercialized POZEN Products at the rates specified in Section 8.2 (Royalties). For purposes of the foregoing royalty obligations, the references to
“Licensee” in Section 8.1 through 8.5 inclusive, and in the related definitions shall be deemed to be, and shall be, references to “POZEN” for purposes of this paragraph. The royalties provided for under this paragraph shall
be the sole payments due by POZEN to Licensee in connection with the practice of such license, and Licensee shall be solely responsible for any payment obligations it may have to Merck & Co., Inc. or its affiliates in connection therewith.

  

	 	(10)	Licensee shall grant to POZEN a non-exclusive, perpetual, irrevocable license under the Product Trademarks to use such marks for the promotion and sale of Commercialized POZEN Products, including the Initial
POZEN Product, in the Field of Use in the Territory. 

 For the avoidance of doubt, in the event that, upon termination pursuant to
Section 12.5 (Termination at Will), Licensee is not able to convey to POZEN the same freedom to operate with respect to the Manufacture and Commercialization of Commercialized POZEN Products in the Territory as Licensee enjoyed immediately
prior to such termination in all material respects, then Licensee shall be obligated to make the applicable payment to POZEN specified in Section 12.6.4(a)(i) (Effect of Termination at Will). 

(b) Any termination fee due pursuant to Section 12.6.4(a) (Effect of Termination at Will) above shall be due within *** (***)
days after Licensee’s exercise of is termination right under Section 12.5 (Termination at Will). 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 12.7 Termination for Insolvency. This Agreement may be terminated by written notice by
either Party at any time during the Term upon the declaration by a court of competent jurisdiction that the other Party is bankrupt and, pursuant to the U.S. Bankruptcy Code such other Party’s assets are to be liquidated; upon the filing or
institution of bankruptcy, liquidation or receivership proceedings (other than reorganization proceedings under Chapter 11 of the U.S. Bankruptcy Code); or upon an assignment of a substantial portion of the assets for the benefit of creditors by the
other Party; or in the event a receiver or custodian is appointed for such Party’s business; provided, however, that in the case of any involuntary proceeding, such right to terminate shall only become effective if the proceeding is not
dismissed within 60 days after the filing thereof (each of the foregoing, a “Bankruptcy Event”). 
 12.8 Effect of
Bankruptcy. All rights and licenses with respect to Patents and Know-How granted under or pursuant to this Agreement by one Party to the other Party are, for all purposes of Section 365(n) of Title 11 of the United States Code
(“Title 11”), licenses of rights to “intellectual property” as defined in Title 11. Each Party agrees that the other Party, as licensee of such rights under this Agreement shall retain and may fully exercise all of its
rights and elections under Title 11. POZEN *** Licensee *** POZEN *** POZEN ***: (i) ***, (ii) ***(iii) ***, (v) ***, (vi) ***, and (vii) ***. POZEN agrees not to interfere with Licensee and its Affiliates’ exercise of
rights and licenses to intellectual property licensed hereunder and embodiments thereof in accordance with this Agreement and agrees to use commercially reasonable efforts to assist Licensee and its Affiliates to obtain such intellectual property
and embodiments thereof in the possession or control of Third Parties as reasonably necessary or desirable for Licensee or its Affiliates to exercise such rights and licenses in accordance with this Agreement. Each party agrees and acknowledges that
all payments by Licensee to POZEN payable under this Agreement other than royalty payments pursuant to Section 8.2 (Royalties) and commercialization milestone payments under the Three-Party Agreement do not constitute “royalties”
within the meaning of Section 365(n) of Title 11 or relate to licenses of intellectual property hereunder. 
 12.9 Formulation
Technology. If Licensee terminates this Agreement for any reason other than for material breach by POZEN under Section 12.3 or as a result of POZEN’s insolvency under Section 12.7, then, subject to the terms and conditions of this
Agreement, Licensee agrees to grant to POZEN, and does hereby grant effective automatically upon such termination, (a) a perpetual, irrevocable, non-exclusive license or sublicense under the Formulation Technology, with the right to grant
sublicenses and authorize the grant of sublicenses to the extent provided in this Section 12.9, to make, have made, use, sell, offer for sale, and import POZEN Products in the Territory and (b) a perpetual, irrevocable, non-exclusive
license or sublicense, as applicable, under the Formulation Technology, with the right to grant sublicenses and authorize the grant of sublicenses to the extent provided in this Section 12.9, to Develop and Manufacture (but not sell or
otherwise Commercialize) POZEN Products outside the Territory solely in support of the Development or Commercialization of the POZEN Products in the Territory; provided, that nothing herein gives POZEN any right or license under any other
intellectual property rights Controlled by Licensee, regardless of whether such rights are necessary in order to exploit the Formulation Technology pursuant to this Section 12.9. POZEN may grant sublicenses and the right to grant further
sublicenses under the foregoing license only as follows: (i) for any sublicense relating to the development or commercialization of a 

  
 -39- 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
Commercialized POZEN Product in the Territory, POZEN may grant such sublicense upon notice to Licensee, but without obtaining Licensee’s consent, and (ii) for any sublicense relating to
POZEN Products other than Commercialized POZEN Products in the Territory, POZEN may grant such sublicense with Licensee’s prior written consent (such consent not to be unreasonably withheld, conditioned or delayed). 

12.10 Survival. Expiration or termination of this Agreement will not relieve the Parties of any obligation accruing prior to such
expiration or termination. The provisions of Sections 8.2 (Royalties), 8.3 (Payments and Sales Reporting), 8.4 (Records; Audits), 9.2 (Prosecution and Maintenance of Joint Patents), 9.3 (Ownership of Inventions), 10.2 (Disclaimer of Warranty), 11
(Confidentiality), 12.6 (Consequences of Expiration and Termination), 12.8 (Effect of Bankruptcy), 12.9 (Formulation Technology), 12.10 (Survival), 13 (Indemnification and Insurance), 14 (Limitation of Liability), and 15 (Miscellaneous) will survive
any termination or expiration of this Agreement (other than a termination pursuant to Section 12.1). 
  

	13.	INDEMNIFICATION AND INSURANCE 

 13.1 Indemnification by POZEN. POZEN hereby agrees
to save, defend and hold Licensee and its Affiliates and their respective directors, officers, employees and agents (each, a “Licensee Indemnitee”) harmless from and against any and all claims, suits, actions, demands, liabilities,
expenses and/or loss, including reasonable legal expense and attorneys’ fees (collectively, “Losses”) (a) to which any Licensee Indemnitee may become subject as a result of any claim, demand, action or other proceeding by
any Third Party to the extent such Losses arise directly or indirectly out of: (i) the gross negligence or willful misconduct of any POZEN Indemnitee or (ii) the breach by POZEN of any warranty, representation, covenant or agreement made
by POZEN in this Agreement; except, in each case, to the extent such Losses result from the gross negligence or willful misconduct of any Licensee Indemnitee or the breach by Licensee of any warranty, representation, covenant or agreement made by
Licensee in this Agreement or (b) for which POZEN is required to indemnify such Licensee Indemnitee pursuant to Section 13.2 of the Original Agreement (other than with respect to those claims, suits, acts, damages, demands, liabilities,
rights of action and causes of action that were released by AstraZeneca AB pursuant to that certain side letter between POZEN and AstraZeneca AB, dated September 16, 2013). 

13.2 Indemnification by Licensee. Licensee hereby agrees to save, defend and hold POZEN and its Affiliates and their respective
directors, officers, employees and agents (each, an “POZEN Indemnitee”) harmless from and against any and all Losses (a) to which any POZEN Indemnitee may become subject as a result of any claim, demand, action or other
proceeding by any Third Party to the extent such Losses arise directly or indirectly out of: (i) the development, manufacture, use, handling, storage, sale or other disposition of any Product by Licensee, its Affiliates or any of their
respective Sublicensees, (ii) the gross negligence or willful misconduct of any Licensee Indemnitee, or (iii) the breach by Licensee of any warranty, representation, covenant or agreement made by Licensee in this Agreement, in each case
((a)(i), (ii), and (iii)), after the Amended and Restated Effective Date; except, in each case, to the extent such Losses result from the gross negligence or willful misconduct of any POZEN Indemnitee or the breach by POZEN of any warranty,
representation, covenant or agreement made by POZEN in this Agreement or (b) for which Licensee is required to indemnify such POZEN Indemnitee pursuant 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
to Section 13.2 of the Original Agreement (other than with respect to those claims, suits, acts, damages, demands, liabilities, rights of action and causes of action that were released by
POZEN pursuant to that certain side letter between POZEN and AstraZeneca AB, dated September 16, 2013). 
 13.3 Indemnification
Procedure. 
 13.3.1 Notice of Claim. The indemnified Party will give the indemnifying Party (the “Indemnifying
Party”) prompt written notice (an “Indemnification Claim Notice”) of any Losses or discovery of fact upon which such Indemnified Party intends to base a request for indemnification under Section 13.1 (Indemnification
by POZEN) or Section 13.2 (Indemnification by Licensee); provided, however, that the failure to give such prompt written notice will not relieve Indemnifying Party of its indemnification obligation under this Agreement except and only to
the extent that the Indemnifying Party is actually prejudiced as a result of such failure. In no event will the Indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification Claim Notice must
contain a description of the claim and the nature and amount of such Loss (to the extent that the nature and amount of such Loss are known at such time). The indemnified Party will furnish promptly to the indemnifying Party copies of all papers and
official documents received in respect of any Losses. All indemnification claims in respect of a Party, its Affiliates or their respective directors, officers, employees and agents (collectively, the “Indemnitees” and each an
“Indemnitee”) will be made solely by such Party to this Agreement (the “Indemnified Party”). 
 13.3.2
Control of Defense. At its option, the Indemnifying Party may assume the defense of any claim for which indemnification is sought (a “Third Party Claim”) by giving written notice to the Indemnified Party within *** (***) days
after the Indemnifying Party’s receipt of an Indemnification Claim Notice. Upon assuming the defense of a Third Party Claim, the Indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected
by the Indemnifying Party. In the event the Indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party will immediately deliver to the Indemnifying Party all original notices and documents (including court papers) received
by any Indemnitee in connection with the Third Party Claim. Should the Indemnifying Party assume the defense of a Third Party Claim, the Indemnifying Party will not be liable to the Indemnified Party or any other Indemnitee for any legal expenses
subsequently incurred by such Indemnified Party or other Indemnitee in connection with the analysis, defense or settlement of the Third Party Claim. 

13.3.3 Right to Participate in Defense. Without limiting Section 13.3.2 (Control of Defense) above, any Indemnitee will be
entitled to participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, however, that such employment will be at the Indemnitee’s own expense unless (i) the
employment thereof has been specifically authorized by the Indemnifying Party in writing, or (ii) the Indemnifying Party has failed to assume the defense and employ counsel in accordance with Section 13.3.2 (Control of Defense) (in which
case the Indemnified Party will control the defense). 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 13.3.4 Settlement. With respect to any Losses relating solely to the payment of money
damages in connection with a Third Party Claim and that will not result in the Indemnitee’s becoming subject to injunctive or other relief or otherwise adversely affect the business of the Indemnitee in any manner, and as to which the
Indemnifying Party will have acknowledged in writing the obligation to indemnify the Indemnitee hereunder, the Indemnifying Party will have the sole right to consent to the entry of any judgment, enter into any settlement or otherwise dispose of
such Loss, on such terms as the Indemnifying Party, in its sole discretion, will deem appropriate, and will transfer to the Indemnified Party all amounts which said Indemnified Party will be liable to pay prior to the time prior to the entry of
judgment. With respect to all other Losses in connection with Third Party Claims, where the Indemnifying Party has assumed the defense of the Third Party Claim in accordance with Section 13.3.2 (Control of Defense), the Indemnifying Party will
have authority to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss provided it obtains the prior written consent of the Indemnified Party (which consent will be at the Indemnified Party’s sole
and absolute discretion). The Indemnifying Party will not be liable for any settlement or other disposition of a Loss by an Indemnitee that is reached without the written consent of the Indemnifying Party. Regardless of whether the Indemnifying
Party chooses to defend or prosecute any Third Party Claim, no Indemnitee will admit any liability with respect to, or settle, compromise or discharge, any Third Party Claim without the prior written consent of the Indemnifying Party. 

13.3.5 Cooperation. The Indemnified Party will, and will cause each other Indemnitee to, cooperate in the defense or prosecution
thereof and will furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and appeals as may be reasonably requested in connection with the defense or prosecution of
any Third Party Claim. Such cooperation will include access during normal business hours afforded to the Indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that are reasonably relevant to such Third
Party Claim, and making Indemnitees and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the Indemnifying Party will reimburse the
Indemnified Party for all its reasonable out-of-pocket expenses in connection therewith. 
 13.4 Expenses. Except as provided above,
the reasonable and verifiable costs and expenses, including fees and disbursements of counsel, incurred by the Indemnified Party in connection with any claim will be reimbursed on a Calendar Quarter basis by the Indemnifying Party, without prejudice
to the Indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the Indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party. 

13.5 Insurance. Each Party will have and maintain such types and amounts of liability insurance as is normal and customary in the
industry generally for parties similarly situated, and will upon request provide the other Party with a copy of its policies of insurance in that regard, along with any amendments and revisions thereto. 

  
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 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

	14.	LIMITATION OF LIABILITY 

 IN NO EVENT WILL EITHER PARTY BE LIABLE FOR LOST PROFITS, LOSS
OF DATA, OR FOR ANY SPECIAL, INDIRECT, INCIDENTAL, CONSEQUENTIAL OR PUNITIVE DAMAGES, HOWEVER CAUSED, ON ANY THEORY OF LIABILITY AND WHETHER OR NOT SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES, ARISING UNDER ANY CAUSE OF ACTION AND
ARISING IN ANY WAY OUT OF THIS AGREEMENT. THE FOREGOING LIMITATIONS WILL NOT APPLY TO AN AWARD OF ENHANCED DAMAGES AVAILABLE UNDER THE PATENT LAWS FOR WILLFUL PATENT INFRINGEMENT AND WILL NOT LIMIT EITHER PARTY’S LIABILITY TO THE OTHER PARTY
UNDER SECTIONS 7.5 (RESTRICTIVE COVENANT), 10.3 (POZEN NON-COMPETE), 11 (CONFIDENTIALITY), AND 13 (INDEMNIFICATION AND INSURANCE) OF THIS AGREEMENT. 
  

	15.	MISCELLANEOUS 

 15.1 Assignment. 

15.1.1 Without the prior written consent of the other Party hereto (which may be granted at the other Party’s discretion), neither
Party will sell, transfer, assign, delegate, pledge or otherwise dispose of, whether voluntarily, involuntarily, by operation of law or otherwise, this Agreement or any of its rights or duties hereunder; provided, however, that either Party
hereto may assign or transfer this Agreement or any of its rights or obligations hereunder without the consent of the other Party (a) to any Affiliate of such Party; or (b) in connection with the transfer or sale of all or substantially
all of the business of such party to which this Agreement relates to a Third Party, whether by merger, sale of stock, sale of assets or otherwise. The assigning Party (except if it is not the surviving entity) will remain jointly and severally
liable with the relevant Affiliate or Third Party assignee under this Agreement, and the relevant Affiliate assignee, Third Party assignee or surviving entity will assume in writing all of the assigning Party’s obligations under this Agreement.
Any purported assignment or transfer in violation of this Section 15.1 (Assignment) will be void ab initio and of no force or effect. 

15.1.2 In the event that POZEN desires to sell all or a part of its rights to receive payments under this Agreement, then upon
POZEN’s written request, Licensee shall enter into a consent in substantially the form of the Consent Agreement attached hereto as Schedule 15.1.2 with respect to such transaction. 

15.2 Termination of Certain Rights Upon POZEN Change of Corporate Control. POZEN shall promptly notify Licensee in writing following
consummation of a Change of Corporate Control of POZEN. Notwithstanding anything else in this Agreement to the contrary, in the event of a Change of Corporate Control of POZEN, then Licensee will have the right, exercisable by written notice to
POZEN or its successor in interest given within *** (***) days after Licensee receives written notice from POZEN of the completion of such Change of Corporate Control: (a) to terminate *** established pursuant to this Agreement; and (b) to
terminate its obligation to make *** POZEN pursuant to this Agreement other than r*** and as reasonably required to ***, except in the event of subsequent termination of this Agreement by Licensee pursuant to Section 12.5 (Termination at Will)
and election by Licensee of the option specified in Section 12.6.4(a)(ii) (Effect of Termination at Will); subject, in each case, to Licensee’s continued compliance with all applicable provisions of this Agreement (including,

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
without limitation, Articles 8, 9 and 11). POZEN shall cooperate in providing to Licensee all information, assistance, assignments and other support reasonably requested to assist Licensee in
assuming such control. For purposes of clarification, all Confidential Information of Licensee in POZEN’s or its successor’s possession following Licensee’s exercise of its rights under this Section 15.2 shall continue to be
subject to all applicable provisions of this Agreement (including, without limitation, Articles 7 and 11). 
 15.3 Severability. If
any provision of this Agreement is held to be illegal, invalid or unenforceable under any present or future law, and if the rights or obligations of either Party under this Agreement will not be materially and adversely affected thereby,
(a) such provision will be fully severable, (b) this Agreement will be construed and enforced as if such illegal, invalid or unenforceable provision had never comprised a part hereof, (c) the remaining provisions of this Agreement
will remain in full force and effect and will not be affected by the illegal, invalid or unenforceable provision or by its severance herefrom, and (d) in lieu of such illegal, invalid or unenforceable provision, there will be added
automatically as a part of this Agreement a legal, valid and enforceable provision as similar in terms to such illegal, invalid or unenforceable provision as may be possible and reasonably acceptable to the Parties herein. To the fullest extent
permitted by Applicable Law, each Party hereby waives any provision of law that would render any provision prohibited or unenforceable in any respect. 

15.4 Governing Law; Dispute Resolution. 

15.4.1 This Agreement, and any disputes between the Parties related to or arising out of this Agreement, including the Parties’
relationship created hereby, the negotiations for and entry into this Agreement, its conclusion, binding effect, amendment, coverage, termination, or the performance or alleged non-performance of a Party of its obligations under this Agreement (each
a “Dispute”), will be governed by the laws of the State of New York without reference to any choice of law principles thereof that would cause the application of the laws of a different jurisdiction. 

15.4.2 In the event of any Dispute, a Party may notify the other Party in writing of such Dispute, and the Parties will try to settle
such Dispute amicably between themselves. If the Parties are unable to resolve the Dispute within *** Business Days of receipt of the written notice by the other Party, such Dispute will be referred to the Chief Executive Officers of each of the
Parties (or their respective designees) who will use their good faith efforts to resolve the Dispute within *** Business Days after it was referred to the Chief Executive Officers. 

15.4.3 Any Dispute that is not resolved as provided in Section 15.4.2, whether before or after termination of this Agreement, will
be resolved by litigation in the courts of competent jurisdiction located in New York, New York. Each Party hereby agrees to the exclusive jurisdiction of such courts and waives any objections as to the personal jurisdiction or venue of such courts.

 15.4.4 Notwithstanding the foregoing, nothing in this Section 15.4 (Governing Law; Dispute Resolution) will limit either
Party’s right to seek immediate temporary injunctive or other temporary equitable relief whenever the facts or circumstances would permit a Party to seek such relief in a court of competent jurisdiction. 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 15.5 Notices. All notices or other communications that are required or permitted
hereunder will be in writing and delivered personally, sent by facsimile (and promptly confirmed by personal delivery or overnight courier as provided herein), or sent by internationally-recognized overnight courier addressed as follows: 

 

	
	 If to POZEN, to:

	
	 POZEN Inc.

	 1414 Raleigh Road, Suite 400

	 Chapel Hill, NC 27517

	 USA

	 Attention: President and CEO

	 Facsimile: (919) 913-1039

	
	 With a copy to:

	
	 DLA Piper LLP (US)

	 51 John F. Kennedy Parkway, Suite 120

	 Short Hills, New Jersey 07078

	 USA

	 Attention: Andrew P. Gilbert

	 Facsimile: (973) 520-2575

	
	 If to Licensee, to:

	
	 AstraZeneca AB

	 SE-431 83

	 Mölndal

	 Sweden

	 Attention: Manager Legal Department Mölndal

	 Facsimile: +46 31 776 38 71

  
 -45- 

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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 or to such other address as the Party to whom notice is to be given may have furnished to the other Party in
writing in accordance herewith. Any such communication will be deemed to have been given (i) when delivered, if personally delivered or sent by facsimile on a Business Day, and (ii) on the second Business Day after dispatch, if sent by
nationally-recognized overnight courier. It is understood and agreed that this Section 15.5 (Governing Law; Dispute Resolution) is not intended to govern the day-to-day business communications necessary between the Parties in performing their
duties, in due course, under the terms of this Agreement. 
 15.6 Entire Agreement; Modifications. This Agreement including the
Exhibits attached hereto, each of which is hereby incorporated and made part of in this Agreement by reference, together with that certain side letter between POZEN and AstraZeneca AB, dated September 16, 2013, and the Three-Party Agreement,
sets forth and constitutes the entire agreement and understanding between the Parties with respect to the subject matter hereof and supersedes all prior agreements, understandings, promises and representations, whether written or oral, with respect
thereto. Each Party confirms that it is not relying on any representations or warranties of the other Party except as specifically set forth herein. No amendment or modification of this Agreement will be binding upon the Parties unless in writing
and duly executed by authorized representatives of both Parties. Subject to Section 11.1 (Confidentiality) hereof, the Parties hereby confirm that the Confidentiality Agreement by and between the Parties, dated as of June 15, 2006 is
hereby terminated. 
 15.7 Relationship of the Parties. It is expressly agreed that the Parties’ relationship under this
Agreement is strictly one of licensor-licensee, and that this Agreement does not create or constitute a partnership, joint venture, or agency. Neither Party will have the authority to make any statements, representations or commitments of any kind,
or to take any action, which will be binding (or purport to be binding) on the other. 
 15.8 Waiver. Any term or condition of this
Agreement may be waived at any time by the Party that is entitled to the benefit thereof, but no such waiver will be effective unless set forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. The
waiver by either Party hereto of any right hereunder or of claims based on the failure to perform or a breach by the other Party will not be deemed a waiver of any other right hereunder or of any other breach or failure by said other Party whether
of a similar nature or otherwise. 
 15.9 Counterparts. This Agreement may be executed in two or more counterparts, each of which
will be deemed an original, but all of which together will constitute one and the same instrument. 
 15.10 No Benefit to Third
Parties. The representations, warranties, covenants and agreements set forth in this Agreement are for the sole benefit of the Parties hereto and their successors and permitted assigns, and they will not be construed as conferring any rights on
any Third Party. 

  
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WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 15.11 Further Assurance. Each Party will duly execute and deliver, or cause to be duly
executed and delivered, such further instruments and do and cause to be done such further acts and things, including the filing of such assignments, agreements, documents and instruments, as may be necessary or as the other Party may reasonably
request in connection with this Agreement or to carry out more effectively the provisions and purposes, or to better assure and confirm unto such other Party its rights and remedies under this Agreement. 

15.12 No Drafting Party. This Agreement has been submitted to the scrutiny of, and has been negotiated by, both Parties and their
counsel, and will be given a fair and reasonable interpretation in accordance with its terms, without consideration or weight being given to any such terms having been drafted by any Party or its counsel. No rule of strict construction will be
applied against either Party. 
 15.13 Construction. Except where the context otherwise requires, wherever used, the use of any
gender will be applicable to all genders and the word “or” is used in the inclusive sense (and/or). The captions of this Agreement are for convenience of reference only and in no way define, describe, extend or limit the scope or intent of
this Agreement or the intent of any provision contained in this Agreement. The term “including” as used herein means including, without limiting the generality of any description preceding such term. Unless the context indicates otherwise,
the singular will include the plural and the plural will include the singular. Unless the context requires otherwise, (a) any definition of or reference to any agreement, instrument or other document refer to such agreement, instrument or other
document as from time to time amended, supplemented or otherwise modified (subject to any restrictions on such amendments, supplements or modifications set forth herein or therein), (b) any reference to any laws refer to such laws as from time
to time enacted, repealed or amended, (c) the words “herein”, “hereof” and “hereunder”, and words of similar import, refer to this Agreement in its entirety and not to any particular provision hereof, and
(d) all references herein to Sections and Exhibits, unless otherwise specifically provided, refer to the Sections and Exhibits of this Agreement. 

15.14 Amendment and Restatement. This Agreement, together with the U.S. Agreement, constitutes an amendment and restatement of the
Original Agreement effective from and after the Amended and Restated Effective Date. All rights or obligations owing under the Original Agreement, or based on facts or events occurring or existing prior to the Amended and Restated Effective Date,
shall be governed by the Original Agreement. As of the Amended and 

  
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Restated Effective Date, the Original Agreement is hereby amended, supplemented, modified and restated in its entirety as described herein and in the U.S. Agreement. For clarity, in no event
shall this Section 15.14 or any other provision in this Agreement be deemed to limit or otherwise affect the agreements made by AstraZeneca AB, Horizon and POZEN in the Three-Party Agreement or that certain side letter agreement between POZEN
and AstraZeneca AB dated September 16, 2013 with respect to each party’s respective liability in connection with the Original Agreement, this Agreement or the U.S. Agreement. 

[Remainder of page intentionally left blank. Signature page follows.] 

  
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 IN WITNESS WHEREOF, the Parties have executed this Amended and Restated Collaboration and License
Agreement for outside the United States by their respective authorized representatives as of the date first written above. 
  

					
		  	POZEN INC.
			
		  	By:	  	 /s/ John R. Plachetka

		  	Name:	  	John R. Plachetka
		  	Title:	  	Chairman, President & CEO
		
		  	ASTRAZENECA AB (publ)
			
		  	By:	  	 /s/ Jan-Olof Jacke

		  	Name:	  	Jan-Olof Jacke
		  	Title:	  	President

 [Signature Page to Pozen ROW Agreement] 

  

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Schedule 1.46 

Licensed Patents 
  

							
	 SERIAL NUMBER/

FILING DATE
	  	PUBLICATION NUMBER/ DATE	 	TITLE	 	TERRITORY
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***
	 ***
	  	***	 	***	 	***

  

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Schedule 4.1.2 

IMS MAT Data 
  

					
	***markets	  	MAT
Q4/05	 
	(***) Combined	  	Sales USD	 
	 	  	Thousands	 
	 Total
	  	 	***	  
	 US TOTAL
	  	 	***	  
	 JAPAN COMBINED
	  	 	***	  
	 FRANCE COMBINED
	  	 	***	  
	 TURKEY RETAIL
	  	 	***	  
	 ITALY COMBINED
	  	 	***	  
	 U.K. COMBINED
	  	 	***	  
	 MEXICO RETAIL
	  	 	***	  
	 BRAZIL RETAIL
	  	 	***	  
	 GERMANY COMBINED
	  	 	***	  
	 CANADA COMBINED
	  	 	***	  
	 SPAIN COMBINED
	  	 	***	  
	 KOREA COMBINED
	  	 	***	  
	 PORTUGAL RETAIL
	  	 	***	  
	 INDIA RETAIL
	  	 	***	  
	 VENEZUELA RETAIL
	  	 	***	  
	 POLAND COMBINED
	  	 	***	  
	 AUSTRALIA COMBINED
	  	 	***	  
	 GREECE RETAIL
	  	 	***	  
	 ARGENTINA RETAIL
	  	 	***	  
	 NETHERLANDS COMBINED
	  	 	***	  
	 Total Others
	  	 	***	  

  

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Schedule 8.2.1 

Segregated Royalty Example 
 For Products
sold in the Territory: In ***, AstraZeneca has Net Sales for *** *** in country Y in the amounts of *** for the first Product and *** for the ***. In *** in all other countries of the Territory the total Net Sales of Products are $***, and Net Sales
do not occur in any other country for more than ***. The calculation of the Segregated Royalty Amount would be: 
  

													
	 ***
	 	***	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***	 	***	 	***
		 		 		 		 	***	 	***	 	***
		 		 		 		 	***	 		 	***

 The calculation of the Remaining Royalty Amount would be: 

 

									
	 ***
	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***

 The total royalty payable for all Net Sales in the Territory would be $***. 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Schedule 8.2.3 

Market Reduction Example 
 For Products
sold in the Territory: Assume that in the calendar year *** the total Net Sales of Products are $***. In that example the following royalties would be payable prior to application of any Market Reduction: 

 

									
	 ***
	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***

 Assume that in country X during the first *** a Competing Product had commenced sales in country X, and in the first Calendar
Quarter of *** achieved the criteria to trigger a Market Reduction under Section 8.2.3 (Rate Step Down for Competing Product Entrants). Assume that Net Sales of Products in country X were $***. 

*** 
  

											
	 ***
	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 	***	 	***	 	***	 	***
	 ***
	 	***	 		 	***	 		 	***

 The Market Reduction in country X would result in a reduction to royalties payable of an amount equal to $***). Therefore the
total royalty payable for Product Net Sales would be $***. 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 Schedule 15.1.2 

Form of Consent Agreement 

CONSENT AGREEMENT 

This Consent Agreement (this “Consent”) is made and entered into as of
[                    ] the Effective Date by and between POZEN Inc., a Delaware corporation (“Sponsor”), and [AstraZeneca AB, a
corporation organized under the laws of Sweden][Horizon Pharma USA, Inc., a Delaware corporation] (“Counterparty”). Sponsor and Counterparty are parties to the Amended and Restated Collaboration and License Agreement for [Outside]
the United States effective as of November     , 2013, and any amendments thereto (collectively, the “Agreement”). As of the Effective Date, Sponsor is considering a transaction to sell all or part of its rights
to receive payments under Sections [8.2, 9.6.4 and 12.6.4(b)(i) of the Agreement and paragraph 5 of that certain letter agreement by and among Sponsor, Counterparty and Horizon Pharma USA dated November     , 2013, as well as
certain related information rights under Sections 8.3 and 8.4 of the Agreement and certain recovery rights under Section 8.5 of the Agreement] [8.1 and 9.6.4 of the Agreement and paragraph 5 of that certain letter agreement by and among
Sponsor, Counterparty and AstraZeneca AB dated November     , 2013, as well as certain related information rights under Sections 8.2 and 8.3 of the Agreement and certain recovery rights under Section 8.4 of the Agreement]
(collectively, “Rights”; such contemplated transaction, the “Transaction”). In connection with the Transaction, Sponsor is requesting Counterparty to give its consent under the Agreement to certain matters, as set
forth below. Capitalized terms not otherwise defined herein shall have the meaning ascribed to them in the Agreement. 
 1.
Assignability. Notwithstanding Section 15.1 of the Agreement, Counterparty hereby consents and agrees that in connection the Transaction, Sponsor may sell, assign, pledge as security, contribute, convey, grant or otherwise transfer
(collectively, “assign”) all or any part of the Rights to any one person or entity (whether or not an affiliate of Sponsor) other than a Competitor without the prior written consent of Counterparty in accordance with the terms of
this Consent. In addition, such person or entity (an “Assignee”) of Sponsor may likewise assign such Assignee’s Rights to any one person or entity (whether or not Sponsor or an affiliate of Sponsor) other than a Competitor
without the prior written consent of Counterparty, it being understood and agreed that, all times, there shall only be one single person or entity that holds the Rights (other than Sponsor) and constitutes an “Assignee.”
“Competitor” shall mean any Person, other than Sponsor or its subsidiaries and affiliates, that is in the business of researching, developing or commercializing therapeutics primarily for rheumatoid arthritis and osteoarthritis pain
indications or any company ranked in the top 10 pharmaceutical companies in the United States based on IMS-reported pharmaceutical sales for the preceding calendar year (or any of such company’s subsidiaries or controlled affiliates). 

2. Payment Direction; Reports. Following the consummation of the Transaction, Sponsor shall remain responsible for the performance of
its obligations and the exercise of its rights under the Agreement, however, Counterparty agrees that, upon written notice from 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
Sponsor (or any direct or indirect permitted Assignee contemplated by Section 1 above), Counterparty shall deliver any future payments contemplated by the Agreement, together with any
royalty or other reports or statements contemplated by the Agreement (“Reports”) to the Assignee, in accordance with the directions in such written notice; provided copies of Reports are also simultaneously sent to the Sponsor. 

3. Prospective Assignee Confidentiality. Notwithstanding Section 11 of the Agreement, Counterparty consents and agrees that
Sponsor, in connection with the Transaction, may disclose Confidential Information to its advisors, affiliates, agents, assignees, auditors, bankers, co-investors, contractors, counsel, directors, employees,
financing parties, insurance providers, investors, lenders, managers, members, officers, partners, sublicensees, trustees or other representatives or any third party that has, or proposes to have, an interest (whether direct or indirect) in the
Rights (each, a “Recipient”), provided that each such Recipient (a) is not a Competitor and (b) shall agree to keep such Confidential Information confidential on reasonable and customary terms pursuant to a non-disclosure
agreement between Sponsor (or an affiliate of Sponsor) and such Recipient, which non-disclosure agreement shall, among other things, provide that (i) if such Recipient is not a prospective Assignee identified by the Company or a holder of a
debt or equity interests therein (a “Prospective Assignee”), the term of such non-disclosure agreement shall extend for a period of 24 months from the date of such nondisclosure agreement, (ii) if such Recipient is a
Prospective Assignee, the term of such non-disclosure agreement shall extend for a period of 24 months from the date such Prospective Assignee notifies Sponsor that it ceases to have an interest in the Transaction, (iii) such Recipient shall
use any Confidential Information so disclosed only to evaluate, enter into, monitor or enforce the Transaction, (iv) upon expiration of such non-disclosure agreement, such Recipient promptly shall destroy the Confidential Information or return
the Confidential Information to Sponsor, as directed by Sponsor, provided that in each case an appropriate person within such Recipient’s organization may retain one copy of such Confidential Information subject to the provisions hereof if
required to comply with internal record retention policies or regulatory considerations, and (v) Counterparty shall be treated as a third party beneficiary of such non-disclosure agreement and shall have the right to enforce any provision of
such non-disclosure agreement against such Recipient. For the avoidance of doubt, the term “Confidential Information” shall include unredacted copies of the Agreement, all royalty reports provided by Counterparty pursuant to Section
[8.3.1][8.2.1] of the Agreement, and material notices and correspondence received by Sponsor relating to or involving the Agreement that affect the Rights. 

4. Final Assignee Confidentiality. If Sponsor consummates the Transaction, Sponsor shall cause the Assignee to agree, pursuant to the
definitive documentation for the Transaction, to be bound by confidentiality provisions in substantially the same form and substance as those confidentiality provisions contained in Section 11 of the Agreement (with such Counterparty being
treated as a third party beneficiary of such provisions to the same extent as is contemplated by clause (v) of Paragraph 3 hereof). 

5. Consent Concerning Additional Disclosures. Counterparty hereby consents to and agrees that Sponsor may disclose to its advisors,
including its consulting firm, L.E.K. Consulting (“LEK”), and the Sponsor, its advisors and/or LEK may in turn disclose to 

 CONFIDENTIAL TREATMENT HAS BEEN REQUESTED AS TO CERTAIN PORTIONS OF THIS DOCUMENT. EACH SUCH PORTION,
WHICH HAS BEEN OMITTED HEREIN AND REPLACED WITH AN ASTERISK ***, HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION 
  

 
Prospective Assignees (who are not Competitors and who have agreed to the confidentiality obligations set forth in Paragraph 3 hereof) , the following information provided to Sponsor by
Counterparty: [(i) the anticipated launch dates of commercial sales of Vimovo by Counterparty in countries outside the United States;][ (ii) information pertaining to the Counterparty’s new US sales model for Vimovo implemented in 2012;]
(iii) historical information relating to the ratio of Vimovo gross sales to net sales[; and (iv) information relating to Counterparty’s promotional plan for Vimovo and strategy regarding Medicare Part D]. 

6. Termination. Unless a definitive agreement with respect to the Transaction has been executed prior to the first anniversary of the
Effective Date, this Consent shall automatically terminate as of the first anniversary of the Effective Date. 
 Except as supplemented
hereby, all terms and provisions of the Agreement shall remain in full force and effect. This Consent may be executed in any number of counterparts, each of which shall be deemed an original, and all of which, taken together, shall constitute one
and the same agreement. An executed signature page of this Consent delivered by facsimile transmission or in PDF format via email shall be as effective as an original executed signature page. This Consent shall be governed by the laws of the State
of New York without regard to any choice of law principles thereof that would cause the application of the laws of a different jurisdiction. 
  

			
	POZEN INC.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	[ASTRAZENECA AB (publ)][HORIZON PHARMA USA, INC.]
		
	By:	 	  

	Name:	 	
	Title:Exhibit 10.1

 

CONSULTING AGREEMENT

 

THIS AGREEMENT (this “Agreement”) is made effective as of September 22, 2014 (the “Effective Date”) by and between ALCO Stores, Inc., a Kansas corporation (the “Company”) and Michael Moore (“Consultant”).  The Company and Consultant sometimes are referred to herein individually as a “Party” and together as the “Parties.”

 

WHEREAS, the Company desires to retain Consultant to provide certain consulting services relating to the Company’s business; and

 

WHEREAS, Consultant represents that Consultant has sufficient knowledge of the Company’s business and services, and is ready, willing, and able to perform the professional services described herein.

 

NOW, THEREFORE, in consideration of the foregoing, and the mutual covenants and agreements contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, accepted and agreed to, the Parties hereto, intending to be legally bound, agree to the terms set forth below:

 

1.                                      Definitions.

 

(a)                                 “Company” shall have the meaning set forth in the preamble and all references to Company shall include the Company, its predecessors and its direct or indirect subsidiaries and affiliates.

 

(b)                                 “Company-Related Inventions and Developments” means all Inventions and Developments which either (i) relate at the time of conception or development to the actual or demonstrably anticipated business of the Company or to its actual or demonstrably anticipated research and development, and result from any work performed for the Company, whether or not during normal business hours; or (ii) are developed through the use of the Company’s Proprietary Information, equipment and software, or other facilities or resources.

 

(c)                                  “Inventions and Developments” means any and all inventions, developments, creative works and useful ideas of any description whatsoever, whether or not patentable.  Inventions and Developments include, by way of example and without limitation, discoveries and improvements which consist of or relate to any form of Proprietary Information.

 

(d)                                 “Proprietary Information” means information which the Company possesses or to which the Company has rights.  Proprietary Information includes, by way of example and without limitation, confidential information, patents, patent applications (U.S. and foreign), know-how, trade secrets, product ideas and service offerings, designs, configurations, inventions, subject matter contained in patent applications, methods, formula, data, applications, documentation, procedures, processes, techniques, devices, apparatuses, systems, software, improvements, marketing plans and strategies, sales and financial reports and forecasts, customer lists, copyrights, ideas, and concepts, whether or not copyrightable or patentable, in any form or media, including but not limited

 

 

to any computer software program.  Proprietary Information includes all Company-Related Inventions and Developments and all information developed by Consultant as a result of the rendering of Services (as defined herein) to the Company or otherwise relating to Inventions and Developments which belong to the Company under Section 10 below.

 

2.                                      Consulting Arrangement.  Consultant shall serve as a consultant to the Company for the period beginning on the Effective Date and ending one month after the Effective Date unless this Agreement is otherwise earlier terminated as herein provided (the “Initial Consulting Period”).  Such Consulting Period shall be renewed automatically for successive additional one-month terms (each a “Renewal Consulting Period” and together with the Initial Consulting Period, the “Consulting Period”) unless the Company provides written notice to Consultant which shall not be less than ten (10) days prior to termination of the Initial Consulting Period or the then-current Renewal Consulting Period.  During the Consulting Period, Consultant shall render such services (“Services”) as the Company may, from time to time, reasonably request, in order that the Company can benefit from Consultant’s experience and knowledge of the Company’s business and industry.

 

3.                                      Compensation.  Subject to the performance by Consultant of his duties and obligations to the Company, as compensation for Services performed under and during the Consulting Period, the Company shall pay Consultant consulting fees equal to $40,000 per month (the “Consulting Fees”).  Consulting Fees shall be payable in accordance with the Company’s policies as in effect from time to time.  Except as otherwise provided in this Agreement, the Consulting Fees shall be prorated for any period of service less than one month.

 

4.                                      Term; Termination.  This Agreement shall extend through the Consulting Period, subject to earlier termination in accordance with the following:

 

(a)                                 The Company may terminate this Agreement at any time by ten (10) days’ prior written notice to Consultant for any or no reason.  Upon Consultant’s receipt of such notice of termination, Consultant will immediately discontinue all work with respect to the Services and will incur no further expenses hereunder without the Company’s prior written approval.

 

(b)                                 Consultant may terminate this Agreement by ten (10) days’ prior written notice to the Company.

 

(c)                                  Either party may terminate this Agreement by written notice to the other party if such other party makes a general assignment for the benefit of creditors, or files a voluntary petition in bankruptcy or for reorganization or arrangement under the bankruptcy laws, or if a petition in bankruptcy is filed against such other party and is not dismissed within thirty (30) days after the filing, or if a receiver or trustee is appointed for all or any part of the property or assets of such other party.

 

(d)                                 Upon termination of this Agreement for any reason, (i) the Company shall be obligated to pay the Consulting Fees earned under the provisions of this Agreement only for Services performed and previously approved expenses incurred up to and including the date of termination, (ii) the rights and obligations of the parties under Sections 8 through 26 hereof shall remain effective and enforceable in accordance with their terms, (iii) each party shall remain liable

 

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for any breach of this Agreement occurring during the term hereof and (iv) in all other respects this Agreement shall terminate and be of no further force or effect.

 

5.                                      Expenses.  In connection with the performance of the Services hereunder, the Company shall reimburse Consultant for all reasonable and pre-approved out-of-pocket costs and expenses incurred by Consultant solely in furtherance of Consultant’s performance of the Services within thirty (30) days from the end of the month in which Consultant submits statements detailing such costs and expenses.

 

6.                                      Status of Consultant as Independent Contractor.  The relationship of Consultant to the Company is that of an independent contractor, and nothing herein contained shall be construed or deemed as creating any other relationship.  Without limiting the foregoing, the relationship between the parties hereto shall not be deemed to be that of an employer-employee, joint venture, or partnership.  As an independent contractor, Consultant shall have the sole responsibility for paying taxes, workers compensation, employee benefits, and all similar obligations with respect to himself and his employees (if any), and shall perform the Services in such a manner and at such times as Consultant deems the most appropriate to achieve the Company’s objectives with respect thereto.

 

7.                                      Taxes.  All taxes, whether local, state, or federal, imposed upon this Agreement or any sums paid hereunder shall be borne by Consultant without reimbursement by the Company.

 

8.                                      Confidentiality.  Consultant understands and agrees that this Agreement creates a relationship of confidence and trust between Consultant and the Company with respect to (a) all Proprietary Information and (b) the confidential information of others with which the Company has a business relationship.  The information referred to in clauses (a) and (b) of the preceding sentence is referred to in this Agreement, collectively, as “Confidential Information.”  At all times, both during the Consulting Period and after its termination or expiration, as the case may be, Consultant will keep in confidence and trust all such Confidential Information, and will not use or disclose any such Confidential Information without the written consent of the Company, except as may be necessary in the ordinary course of performing Consultant’s duties to the Company.  The restrictions set forth in this Section 8 will not apply to information which is generally known to the public, unless such knowledge results from an unauthorized disclosure by Consultant or a breach of any duty owed to the Company.

 

9.                                      Documents, Records, etc.  All documents, records, apparatus, equipment and other physical property, whether or not pertaining to Proprietary Information, which are furnished to Consultant by the Company or are produced by Consultant as a result of the rendering by Consultant of Services hereunder will be and remain the sole property of the Company.  Consultant will return to the Company all such materials and property as and when requested by the Company.  In any event, Consultant will return all such materials and property immediately upon the expiration of the Consulting Period, or earlier, if this Agreement is otherwise terminated for any reason.  Consultant will not take or remove any such material or property or any copies thereof upon such termination.

 

3

 

10.                               Ownership of Proprietary Information and Inventions and Developments.  Consultant agrees that the Company is the sole owner of all Proprietary Information and all Company-Related Inventions and Developments.  Consultant further agrees that the Company is the sole owner of any Inventions and Developments which Consultant may conceive, create, develop or contribute to during the Consulting Period relating to the actual or demonstrably anticipated business of the Company or developed through the use of the Company’s Proprietary Information, equipment and software, or other facilities or resources, along with all causes of action, known or unknown, which have accrued or will accrue, from the conception or creation of any or all of the foregoing, and all such Inventions and Developments shall be deemed to be Company-Related Inventions and Developments.  Consultant shall have no publication rights and all of the same shall belong exclusively to the Company.  Consultant hereby transfers and assigns to the Company any proprietary rights which Consultant may have or acquire in any such Company-Related Inventions and Developments and Consultant waives any publication rights, moral rights or other special rights which Consultant may have or accrue therein.  Consultant agrees to execute any documents and take any actions that may be required to effect and confirm such transfer and assignment and waiver.  The provisions of this Section 10 will apply to all Company-Related Inventions and Developments which are conceived or developed during the Consulting Period whether or not further development or reduction to practice may take place after the Consulting Period.  The provisions of this Section 10 will not apply, however, to any Inventions and Developments created and/or conceived by Consultant prior to the Effective Date.

 

11.                               Disclosure of Proprietary Information and Inventions and Developments.  Consultant agrees promptly to disclose to the Company, or any persons designated by it, all Proprietary Information and Company-Related Inventions and Developments which are or may be subject to the provisions of Section 10.

 

12.                               Obtaining and Enforcing Proprietary Rights.  Consultant agrees to assist the Company, at the Company’s request from time to time and at the Company’s expense, to obtain and enforce patents, copyrights or other proprietary rights with respect to Company-Related Inventions and Developments in any and all countries.  Consultant will execute all documents reasonably necessary or appropriate for this purpose.  This obligation will survive the termination or expiration of the Consulting Period provided that the Company will compensate Consultant at a reasonable rate after such termination for time actually spent by Consultant at the Company’s request on such assistance.  In the event that the Company is unable for any reason whatsoever to secure Consultant’s signature to any document reasonably necessary or appropriate for any of the foregoing purposes (including renewals, extensions, continuations, divisions or continuations in part), Consultant hereby irrevocably designates and appoints the Company and its duly authorized officers and agents as Consultant’s agents and attorneys-in-fact to act for Consultant and on Consultant’s behalf, but only for the purpose of executing and filing any such document and doing all other lawfully permitted acts to accomplish the foregoing purposes with the same legal force and effect as if executed by Consultant.

 

13.                               Competitive Activities.  During the Consulting Period and for a period of twelve (12) months thereafter, Consultant (i) will not, directly or indirectly, whether as owner, partner, shareholder, consultant, agent, employee, co-venturer or otherwise, engage, participate or

 

4

 

invest in any business activity anywhere in the world (a “Competitor”) which develops, manufactures or markets products or performs services which are competitive with or similar to the products or services of the Company, or products or services which the Company has under development or which are the subject of active planning at any time during the Consulting Period; (ii) will refrain from directly or indirectly employing, attempting to employ, recruiting or otherwise soliciting, inducing or influencing any person to leave the employment of the Company; and (iii) will refrain from soliciting or encouraging any customer or supplier to terminate or otherwise modify adversely its business relationship with the Company.  Notwithstanding the foregoing, Consultant understands that she may hold stock in a Competitor if the stock is publicly traded and the amount of stock Consultant holds is less than 1% of the outstanding capital stock of the Competitor.  Company acknowledges that the products and services of the Company are comprised of numerous components and the restrictions set forth in this Section 13 are not intended to prevent Consultant from working for a company that manufactures such components so long as such company does not develop, manufacture or market finished products or perform services which are competitive with or similar to the products or services of the Company, or products or services which the Company has under development or which are the subject of active planning at any time during the Consulting Period.  Consultant understands that the restrictions set forth in this Section 13 are intended to protect the Company’s interest in its Proprietary Information and established customer relationships and goodwill, and agrees that such restrictions are reasonable and appropriate for this purpose.

 

14.                               Third-Party Agreements and Rights.  Consultant hereby confirms that Consultant is not bound by the terms of any agreement with any current or previous employer or other party which restricts in any way Consultant’s use or disclosure of information or Consultant’s engagement in any business, except as may be disclosed in a separate Schedule attached to this Agreement prior to its acceptance by the Company.  Consultant has delivered to the Company true and complete copies of any agreements listed on said Schedule.  Consultant represents to the Company that Consultant’s execution of this Agreement, Consultant’s engagement with the Company and the performance of Consultant’s proposed duties for the Company will not violate any obligations Consultant may have to any such current or previous employer or other party.  In Consultant’s work for the Company, Consultant will not, in violation of any agreements with or rights of any such current or previous employer or other party, disclose or make use of, or bring on the premises of the Company, any non-public information (including any copies or other tangible embodiments thereof) belonging to or obtained from any such current or previous employer or other party.

 

15.                               Extent of Service.  During the Consulting Period, Consultant agrees to use Consultant’s best efforts in, and shall devote the necessary amount of Consultant’s working time, attention, skill and energies to, the advancement of the interests of the Company and its subsidiaries and the performance of Consultant’s duties and responsibilities in connection with the rendering by Consultant of Services hereunder.

 

16.                               Injunction.  Consultant agrees that it would be difficult to measure any damages caused to the Company which might result from any breach by Consultant of the promises set forth in this Agreement, and that in any event money damages would be an inadequate remedy for any such breach.  Accordingly, Consultant agrees that if Consultant breaches, or proposes to breach,

 

5

 

any portion of this Agreement, the Company shall be entitled, in addition to all other remedies that it may have, to an injunction or other appropriate equitable relief to restrain any such breach without showing or proving any actual damage to the Company or posting of any bonds.

 

17.                               Binding Effect.  This Agreement will be binding upon Consultant and Consultant’s heirs, executors, administrators and legal representatives and will inure to the benefit of the Company, any subsidiary of the Company, and its and their respective successors and assigns.

 

18.                               Enforceability.  If any portion or provision of this Agreement is to any extent declared illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, will not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law.  In the event that any provision of this Agreement is determined by any court of competent jurisdiction to be unenforceable by reason of excessive scope as to geographic, temporal or functional coverage, such provision will be deemed to extend only over the maximum geographic, temporal and functional scope as to which it may be enforceable.

 

19.                               Entire Agreement.  This Agreement constitutes the entire agreement between the Company and Consultant with respect to the subject matter hereof, and supersedes all prior representations and agreements with respect to such subject matter.  This Agreement may not be amended, modified or waived except by a written instrument duly executed by the person against whom enforcement of such amendment, modification or waiver is sought.  The failure of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach of this Agreement, in any particular case will not prevent any subsequent enforcement of such term or obligation or to be deemed a waiver of any separate or subsequent breach.

 

20.                               Notices.  Any notice or demand which, by any provision of this Agreement or any agreement, document or instrument executed pursuant hereto or thereto, except as otherwise provided therein, is required or provided to be given shall be deemed to have been sufficiently given or served and received for all purposes when delivered by hand, telecopy, telex or other method of facsimile or five (5) days after being sent by certified or registered mail, postage and charges prepaid, return receipt requested, or two (2) days after being sent by overnight delivery providing receipt of delivery, to the following addresses:  if to the Company, at its address as shown on the signature page hereof, or at any other address designated by the Company to Consultant in writing; and if to Consultant, at Consultant’s mailing address as shown on the signature page hereof, or at any other address designated by Consultant to the Company in writing.

 

21.                               Assignment.  Services of Consultant are personal in nature and as such, no rights or obligations under this Agreement may be assigned to any person, by operation of law, or otherwise, without the express written approval of the Company.  The Company may assign its rights and obligations hereunder to any party, provided that the assignee shall assume all of the Company’s obligations hereunder.

 

6

 

22.                               Publicity.  No publicity or advertising shall be released by Consultant with respect to the activities, duties, and terms of this Agreement, without the prior written approval of the Company.  Upon execution of this Agreement by the Company and Consultant, the Company may issue a press release to announce that Consultant is affiliated with the Company.  The Company shall also have the right to identify Consultant as a consultant and advisor of the Company in the Company’s written materials and on the Company’s websites.

 

23.                               Currency.  Unless otherwise provided for herein, all monetary amounts referred to herein shall refer to the lawful money of the United States.

 

24.                               Governing Law.  This Agreement shall be governed by and construed in accordance with the laws of the State of Kansas.

 

25.                               Counterparts.  This Agreement may be executed in counterparts, each of which shall be deemed an original and such counterparts shall be one and the same instrument.

 

26.                               Transmission by Facsimile.  The parties herein agree that this Agreement may be transmitted by facsimile or such similar device and that the reproduction of signatures by facsimile or such similar device will be treated as binding as if originals and each party hereto undertakes to provide each and every other party hereto with a copy of the Agreement bearing original signatures forthwith upon demand.

 

[Remainder of Page Intentionally Left Blank; Signature Page Follows]

 

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IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the Effective Date.

 

 

	
CONSULTANT:
    	
COMPANY:
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
ALCO STORES, INC.
    
	
 
    	
 
    
	
By:
    	
/s/ Michael Moore
    	
 
    	
By: 
    	
/s/ Stanley B. Latacha
    
	
Name:
    	
Michael Moore
    	
Name:
    	
Stanley B. Latacha
    
	
Address:
    	
9001 Hemingway Grove Circle
    	
Title:
    	
Chief Executive Officer
    
	
 
    	
Knoxville, TN 37922
    	
Address:
    	
751 Freeport Parkway
    
	
 
    	
 
    	
Coppell, TX 75019

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