Document:

EX-4.17

 Exhibit 4.17 
  

			
		 	 Deed of Settlement and Release
  

		
		 	Prima Biomed Ltd
		 	ACN 009 237 889
		
		 	Ian Edward Bangs

 Table of Contents 
  

	
	  

  

							
	 1.
	  	Definitions and Interpretation	  	 	1	  
			
	 2.
	  	Agreement	  	 	4	  
			
	 3.
	  	Release by Ian	  	 	5	  
			
	 4.
	  	Indemnification by the Company	  	 	6	  
			
	 5.
	  	Access to Documents	  	 	6	  
			
	 6.
	  	Request Procedure and Return of Company Documents	  	 	8	  
			
	 7.
	  	Warranties	  	 	8	  
			
	 8.
	  	Confidentiality	  	 	9	  
			
	 9.
	  	Mutual non disparagement	  	 	9	  
			
	 10.
	  	General	  	 	10	  
		
	 Schedule 1
	  	 	12	  

 Dated 25 October 2012 

Parties 
  

			
	Prima Biomed Ltd ACN 009 237 889
	Address:	  	Level 7, 151 Macquarie Street, Sydney, NSW, 2000
	Facsimile:	  	+ 61 3 9822 7735
	Attention:	  	Matthew Lehman
	(Company)	  	
	
	Ian Edward Bangs
	Address:	  	
	Facsimile:	  	
	(Ian)	  	

 Background 
  

			
	A	    	Ian commenced employment with the Company on 7 February 2011 and his current title is Chief Financial Officer and Company Secretary. He is employed on the terms of an employment agreement signed by two Company
directors and by Ian in the presence of a witness with a commencement date of 7 February 2011 (Employment Agreement).
		
	 B
	    	On 12 October 2012, the Company notified Ian that it has made his position and role redundant due to operational reasons.
		
	 C
	    	In consideration of the Benefits to be provided by the Company to Ian, Ian agrees to provide the Company with certain releases in accordance with the terms of this deed.

 Operative provisions 

It is agreed as follows. 
  

									
		
	 1.
	    	Definitions and Interpretation
		
	 1.1
	    	Definitions
		
		    	In this deed, unless the contrary intention appears, the following words have the following meanings:
			
		    	Term:	    	Definition:
			
		    	Act	    	any actual or alleged act, omission or conduct of Ian occurring while Ian was acting as Chief Financial Officer and Company Secretary and relating to, arising out of or connected with Ian’s capacity as Chief
Financial Officer and Company Secretary.
			
		    	Benefits	    	the benefits specified in Schedule 1.
			
		    	Business Day	    	a day that is not a Saturday, Sunday, public holiday or bank holiday in NSW.
			
		    	Claim	    	includes any allegation, action, demand, cause of action, suit, proceeding, litigation, investigation, judgment, verdict, damage, loss, cost, expense or liability however arising, whether present, unascertained,
immediate, future or contingent, whether arising at law, in equity, under any statute or under any industrial award, workplace agreement or other instrument made or approved under any law.

  
 1 

									
		    	Company Documents	    	documents provided to the Ian by or on behalf of the Company during Ian’s term of office as Chief Financial Officer and Company Secretary, including board papers, minutes, correspondence, memoranda, financial and
other records, and all documents referred to in those documents.
				
		    	Conduct Claim	    	(a)	    	any legal proceeding (whether civil or criminal), administrative proceeding, arbitral proceeding, mediation or other form of alternative dispute resolution (whether or not held in conjunction with any legal,
administrative or arbitral proceeding) in respect of or arising out of an Act; and
				
		    		    	(b)	    	any written or oral threat, complaint, demand or other circumstance that might reasonably cause Ian to believe that any proceeding referred to in paragraph (a) will be initiated.
				
		    	Confidential Information	    	(a)	    	all information of or used by the Company relating to its transactions, operations and affairs, including without limitation:
					
		    		    		    	(i)	    	trade secrets and intellectual property;
					
		    		    		    	(ii)	    	financial information, financial reports, balance sheets, profit and loss statements and bank accounts;
					
		    		    		    	(iii)	    	strategic plans;
					
		    		    		    	(iv)	    	business plans, proposals and management reports;
					
		    		    		    	(v)	    	marketing and distribution plans;
					
		    		    		    	(vi)	    	information concerning the Company’s clients, suppliers, employees, contractors or agents; and
					
		    		    		    	(vii)	    	commercially sensitive information or other business intelligence;
				
		    		    	(b)	    	all other information treated by the Company as confidential;
				
		    		    	(c)	    	any other information or data that Ian was given or which came to his knowledge during the course of his employment with the Company and was told was confidential, or that a reasonable person would expect from its nature
to be confidential;
				
		    		    	(d)	    	all notes, data, reports and other records (whether or not in tangible form) based on, incorporating or derived from information referred to in paragraphs (a) to (c);
				
		    		    	(e)	    	all copies (whether or not in tangible form) of the information, notes, reports and records referred to in paragraphs (a) to (d),
			
		    		    	that is not public knowledge (otherwise than as a result of a breach of confidentiality of a party).

  
 2 

									
		    	Corporations Act	    	Corporations Act 2001 (Cth).
			
		    	Enforcement Period	    	the period beginning on the date of this deed and ending on 31 December 2019.
				
		    	Investigative Proceeding	    	(a)	    	any investigation, hearing, inquiry or review (however described) undertaken by:
				
		    		    	(b)	    	a Royal Commission, Board of Inquiry, Parliamentary Committee or similar body, committee or commission;
				
		    		    	(c)	    	the Australian Securities and Investments Commission, the Australian Competition and Consumer Commission, ASX Limited or any other regulatory authority;
				
		    		    	(d)	    	a department of any Australian government or of any other jurisdiction;
				
		    		    	(e)	    	a public authority;
				
		    		    	(f)	    	an instrumentality, agent or appointee of the Crown in right of the Commonwealth, a State or a Territory or the equivalent of any such body in any other jurisdiction; or
				
		    		    	(g)	    	any other body, office or person exercising statutory or prerogative power.
			
		    	Permitted Purpose	    	has the meaning given to that term in clause 5.1.
			
		    	Privileged Document	    	any document in respect of which any form of legal privilege applies solely in favour of the Company or jointly in favour of the Company and Ian (whether alone or with other members or former members of the
Company’s Board).
			
		    	Property	    	all items supplied by the Company and used, exclusively or non-exclusively, by Ian during his employment with the Company, including without limitation:
				
		    		    	(a)	    	any computer(s), computer software and disks;
				
		    		    	(b)	    	telephones;
				
		    		    	(c)	    	credit and charge cards;
				
		    		    	(d)	    	office keys and access cards;
				
		    		    	(e)	    	cars and car-keys; and
				
		    		    	(f)	    	information which is Confidential Information.
		
	 1.2
	    	Interpretation
		
		    	In this deed, unless the context indicates a contrary intention:
		
		    	 (a)       the singular includes the plural and vice versa;

  
 3 

											
			
		    	 (b)
	    	another grammatical form of a defined word or expression has a corresponding meaning;
			
		    	 (c)
	    	a reference to a clause, paragraph or schedule is to a clause or paragraph of or schedule to this deed and a reference to this deed includes any schedule or annexure;
			
		    	 (d)
	    	a reference to a document or instrument, includes the document or instrument as novated, altered, supplemented or replaced from time to time;
			
		    	 (e)
	    	a reference to A$, $A, dollar or $ is to Australian currency;
			
		    	 (f)
	    	a reference to time is to New South Wales time;
			
		    	 (g)
	    	a reference to a party to this deed, and a reference to a party to a document includes the party’s executors, administrators, successors and permitted assigns and substitutes;
			
		    	 (h)
	    	a reference to a person includes a natural person, partnership, body corporate, association, governmental or local authority or agency or other entity;
			
		    	 (i)
	    	a reference to a statute, ordinance, code or other law includes regulations and other instruments under it and consolidations, amendments, re-enactments or replacements of any of them;
			
		    	 (j)
	    	the meaning of general words is not limited by specific examples introduced by including, for example or similar expressions;
			
		    	 (k)
	    	a rule of construction does not apply to the disadvantage of a party because the party was responsible for the preparation of this deed or any part of it;
			
		    	 (l)
	    	if a day on or by which an obligation must be performed or an event must occur is not a Business Day, the obligation must be performed or the event must occur on or by the next Business Day;
			
		    	 (m)
	    	a provision which binds more than one party binds those parties jointly and severally; and
			
		    	 (n)
	    	headings are for ease of reference only and do not affect interpretation.
		
	 2.
	    	 Agreement

		
	 2.1
	    	 Ian’s employment

			
		    	 (a)
	    	The parties agree that Ian’s employment with the Company will end on 31 December 2012.
			
		    	 (b)
	    	Ian agrees to continue working on a full-time basis as Chief Financial Officer and co-Company Secretary until 16 November 2012.
			
		    	 (c)
	    	From 17 November 2012 until 31 December 2012, Ian will remain employed by the Company but will not be required to attend the Company’s offices. During this period, Ian agrees to make himself available as
reasonably required by Matthew Lehman, Marc Voigt and Deanne Miller to assist with the transition of the Chief Financial Officer role outside of Australia and the Company Secretary role.

  
 4 

									
	 2.2
	    	Benefits
			
		    	 (a)       
	  	The Company must provide the Benefits to Ian on or before 31 December 2012.
			
		    	 (b)      
	  	The Benefits will be provided to Ian subject to Ian delivering to the Company all Property in his possession, power or control on or before 31 December 2012.
		
	 2.3
	    	Acknowledgements
		
		    	 (a)       Ian acknowledges and agrees that the Benefits to be provided to him include
any entitlements in respect of:

				
		    		  	(i)	    	payment in lieu of notice;
				
		    		  	(ii)	    	accrued annual leave, long service leave or other statutory entitlements;
				
		    		  	(iii)	    	redundancy entitlements;
				
		    		  	(iv)	    	contractual entitlements; and
				
		    		  	(v)	    	any other entitlements or payments owing to Ian under law or equity as a result of the Company making Ian’s employment redundant.
			
		    	 (b)      
	  	authorises the Company to withhold from the Benefits such sum as the Company is required to remit to the Australian Taxation Office in connection with the provision of the Benefits on the basis that his position of
employment with the Company has been made redundant.
		
	 2.4
	    	No admission of liability
		
		    	The parties acknowledge and agree that this deed is entered into without any admission of liability on the part of any party or the part of any person acting on behalf of any party.
		
	 3.
	    	Release by Ian
		
	 3.1
	    	Release
		
		    	In consideration of and conditional upon the performance by the Company of its obligations under this deed, Ian irrevocably and unconditionally releases, discharges and agrees to forever hold harmless the Company, its
directors, officers, employees, contractors and agents (Related Parties) from any and all Claims (other than those Claims arising out of this deed) which he may now have, or could, would or might but for this release have, or have had,
against the Company and the Related Parties (and each of them) with respect to or in any way connected with his employment with the Company or him being made redundant.
		
	 3.2
	    	Benefit of Release
		
		    	Without prejudice to the ability of the Company to enforce this deed for its own benefit:
			
		    	 (a)       
	  	the Company holds the benefit of each release, discharge and covenant not to sue contained in this deed to the extent that it is expressed to apply in favour of its Related Parties on trust for each of its Related
Parties; and
			
		    	 (b)      
	  	the Company may without prior written consent of its Related Parties agree to vary the terms of any release, discharge or covenant not to sue contained in this deed to the extent that it is expressed to apply in favour
of the Related Parties.

  
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	 3.3
	    	Survival
		
		    	The provisions of this clause 3 remain in full force and effect upon the execution of this deed and the provision of the Benefits.
		
	 4.
	    	Indemnification by the Company
		
	 4.1
	    	Indemnification
		
		    	Notwithstanding this deed and the provision of the Benefits, clause 2.3(c) of the Employment Agreement shall remain in full force and effect.
		
	 4.2
	    	Survival
		
		    	The provisions of this clause 4 remain in full force and effect upon the execution of this deed and the provision of the Benefits.
		
	 5.
	    	Access to Documents
		
	 5.1
	    	Permitted Purposes
		
		    	Subject to clauses 5.2 and 5.4, Ian may, during the Enforcement Period and if a request for access is made in accordance with clause 6, have access to the Company Documents for the purposes (each a Permitted
Purpose) of any one or more of:
			
		    	 (a)       
	    	taking any action in relation to any Conduct Claim that Ian has reason to believe will be brought against him or that has actually been brought against him.
			
		    	 (b)      
	    	an Investigative Proceeding pursuant to which Ian is being investigated, or has been called to give evidence, in relation to any Act or facts or circumstances arising or occurring during Ian’s term of office as
Chief Financial Officer and Company Secretary of the Company; or
			
		    	 (c)       
	    	any other purpose for which the Company gives its consent in writing.
		
	 5.2
	    	Limitations on Access
			
		    	 (a)       
	    	Clause 5.2(b) applies if, in the reasonable opinion of the Company:
				
		    		    	(a)	    	giving Ian access to a Company Document under clause 5.1 would or could reasonably be expected to jeopardise the capacity of the Company to claim legal privilege in respect of a Privileged Document; and
				
		    		    	(b)	    	the loss by the Company of the capacity to claim such privilege in respect of the Privileged Document would or could reasonably be expected to result in material prejudice to the Company.
			
		    	 (b)      
	    	If this clause 5.2(b) applies by virtue of clause 5.2(a), then the Company may:

  
 6 

									
				
		    		    	(a)	    	impose such conditions on Ian’s access to that Company Document as it determines, in good faith, are appropriate to ensure that the capacity of the Company to claim legal privilege in respect of the relevant
Privileged Document is not jeopardised by such access; or
				
		    		    	(b)	    	if the Company determines in good faith and acting reasonably that it is not possible to ensure, by the imposition of conditions, that the capacity of the Company to claim privilege in respect of the relevant Privileged
Document would not be jeopardised by such access, deny Ian access to that Company Document.
			
		    	 (c)       
	    	Ian’s right of access to Company Documents under clause 5.1:
				
		    		    	(a)	    	applies only to Company Documents created during Ian’s term of office as Chief Financial Officer and Company Secretary; and
				
		    		    	(b)	    	does not entitle Ian to have access to any personal information contained in any Company Documents to which Ian is given access where that information cannot be disclosed to Ian as a result of the requirements of any
relevant privacy laws.
		
	 5.3
	    	Privileged Documents
			
		    	 (a)       
	    	If Ian requests access to a Company Document that is, or refers to, a Privileged Document and the Company does not exercise its right to impose conditions or deny access under clause 5.2(b), the Company must waive its
claim to legal privilege in respect of that Privileged Document to the extent required under clause 5.3(b) but only if the Company is satisfied, in good faith, that the loss of the right to claim privilege in respect of that Privileged Document
would not result in material prejudice to the Company.
			
		    	 (b)      
	    	Where clause 5.3(a) requires a waiver to be given by the Company, that waiver is required to be given only to the extent necessary to enable Ian to:
				
		    		    	(a)	    	have access to the relevant Company Document;
				
		    		    	(b)	    	disclose the information in the relevant Company Document in circumstances permitted under clause 8; and
				
		    		    	(c)	    	use the relevant Company Document for the Permitted Purpose specified in the notice given by Ian under clause 6.
			
		    	 (c)       
	    	Where Ian is given access under this clause 5 to a Company Document that is or refers to a Privileged Document, Ian must:
				
		    		    	(a)	    	comply with any conditions imposed by the Company under clause 5.2(b); and
				
		    		    	(b)	    	without limiting Ian’s rights under this clause 5 and clause 8, not waive that privilege nor do or omit to do anything that will cause that privilege to be waived or lost, without the prior written consent of the
Company.
			
		    	 (d)      
	    	The Company and Ian acknowledge that the granting of access to Ian does not amount to an express or implied waiver by the Company of its claim to legal privilege.
			
		    	 (e)       
	    	Where the Company Document consists of documents that entitle Ian and the Company to claim joint legal privilege, Ian will not waive, either by express or implied conduct, the joint client legal privilege,
except in proceedings to which the Company is not a party.

  
 7 

									
		
	 5.4
	    	Duration of Access Rights
		
		    	If a Conduct Claim is made against Ian during the Enforcement Period, all of the rights and obligations created by this clause 5, and clauses 6 and 8 will continue to apply until the final determination of the Conduct
Claim.
		
	 6.
	    	Request Procedure and Return of Company Documents
		
	 6.1
	    	Requests
		
		    	A request for access to Company Documents by Ian must:
			
		    	 (a)       
	  	be in writing addressed to the Company’s Board;
			
		    	 (b)      
	  	be made during the Enforcement Period;
			
		    	 (c)       
	  	describe the Company Documents required by Ian; and
			
		    	 (d)      
	  	state the purpose for which the Company Documents are required, which must be a Permitted Purpose.
		
	 6.2
	    	Access
			
		    	 (a)       
	  	Where the Company receives a request for access to specified Company Documents under this clause 6 and is required to provide access to those Company Documents under clause 5, the Company will, within 5 Business Days
after receipt of the request, make the relevant Company Documents available for inspection by Ian at the premises of the Company (or at nominated storage place(s)) during normal business hours or at reasonable times outside business hours by
agreement between the Company and Ian.
			
		    	 (b)      
	  	Where Ian obtains access to Company Documents under clause 6.2(a), he will be entitled to make copies (at his cost) of those Company Documents (but only for a Permitted Purpose).
		
	 6.3
	    	Usage and Retention of Company Documents by Ian
		
		    	Ian must return all Company Documents (including copies) obtained under clause 6 to the Chief Executive Officer of the Company as soon as possible after they are no longer reasonably required for use for a Permitted
Purpose.
		
	 7.
	    	Warranties
		
		    	The parties warrant and represent to each other that:
			
		    	 (a)       
	  	they have read the terms of this deed;
			
		    	 (b)      
	  	they have taken independent legal advice or have been given the opportunity to take legal advice as to the terms, nature, effect and extent of this deed;
			
		    	 (c)       
	  	they have not made any promise, representation or inducement or been a party to any conduct, material to the entry into this deed other then as set out in this deed;

  
 8 

									
			
		    	 (d)      
	  	they have not commenced proceedings against the other party; and
			
		    	 (e)       
	  	they are aware that the other party is relying upon this warranty in executing this deed.
		
	 8.
	    	Confidentiality
		
	 8.1
	    	Terms of deed confidential
		
		    	Each party agrees that the terms of this deed are confidential and are not to be disclosed or permitted to be disclosed in any form or in any manner either directly or indirectly except:
			
		    	 (a)       
	  	as required by law or contractual obligation;
			
		    	 (b)      
	  	on a confidential basis to legal or accounting advisers for the purposes of obtaining legal or accounting advice or services;
			
		    	 (c)       
	  	in the case of Ian, to Ian’s immediate, adult family members, only to the extent the immediate family members agree to keep the information confidential in accordance with this deed; or
			
		    	 (d)      
	  	to the extent necessary for the enforcement of any provision of this deed.
		
	 8.2
	    	Confidential Information
		
		    	Ian must not, without the Company’s prior written consent, whether before or after the date of this deed:
			
		    	 (a)       
	  	use for his or another’s advantage any Confidential Information;
			
		    	 (b)      
	  	disclose to any person, including his immediate family members, any Confidential Information, either directly or indirectly;
			
		    	 (c)       
	  	make copies of any Confidential Information; or
			
		    	 (d)      
	  	counsel, procure or assist any person or corporation to use or disclose any Confidential Information,
		
		    	other than as required to do so by law.
		
	 8.3
	    	Survival
		
		    	The confidentiality provisions of this clause 8 remain in full force and effect upon the execution of this deed and the provision of the Benefits.
		
	 9.
	    	Mutual non disparagement
		
		    	The parties agree that they will not make any comments to other persons or entities which denigrate or disparage the other or otherwise make any statement or publication, whether on social networking sites such as
Facebook, Twitter, MySpace or LinkedIn, or verbally, or permit or authorise any statement or publication to be made, which is calculated or reasonably likely to damage the reputation of the other.

  
 9 

									
		
	 10.
	    	General
		
	 10.1
	    	Entire agreement
		
		    	This deed constitutes the entire agreement between the parties in relation to its subject matter. All prior discussions, undertakings, agreements, representations, warranties and indemnities in relation to that
subject matter are replaced by this deed and have no further effect.
		
	 10.2
	    	No merger
		
		    	The provisions of this deed will not merge on completion of any transaction contemplated in this deed and, to the extent any provision has not been fulfilled, will remain in force.
		
	 10.3
	    	Amendment
		
		    	This deed may not be amended or varied unless the amendment or variation is in writing signed by all parties.
		
	 10.4
	    	Assignment
		
		    	Neither party may assign, transfer or otherwise deal with this deed or any right under this deed without the prior written consent of each other party.
		
	 10.5
	    	Severability
		
		    	Part or all of any provision of this deed that is illegal or unenforceable will be severed from this deed and will not affect the continued operation of the remaining provisions of this deed.
		
	 10.6
	    	Waiver
		
		    	Waiver of any power or right under this deed must be in writing signed by the party entitled to the benefit of that power or right and is effective only to the extent set out in that written waiver.
		
	 10.7
	    	Rights, remedies additional
		
		    	Any rights and remedies that a person may have under this deed are in addition to and do not replace or limit any other rights or remedies that the person may have.
		
	 10.8
	    	Further assurances
		
		    	Each party must do or cause to be done all things necessary or reasonably desirable to give full effect to this deed and the transactions contemplated by it (including, but not limited to, the execution of
documents).
		
	 10.9
	    	Costs
		
		    	Except as specifically provided in this deed, each party must bear its own legal, accounting and other costs for the preparation and execution of this deed.
		
	 10.10
	    	Counterparts
		
		    	This deed may be executed in any number of counterparts and all counterparts taken together will constitute one document.

  
 10 

									
		
	 10.11
	    	Legal Advice
		
		    	Each party acknowledges that it has received legal advice about the terms and effect of this deed or has had the opportunity of receiving such legal advice.
		
	 10.12
	    	Plea in Bar
		
		    	The releases contained in this deed may be pleaded in bar to any subsequent proceedings in respect of any matters the subject of this deed.
		
	 10.13
	    	Governing law and jurisdiction
		
		    	This deed will be governed by and construed in accordance with the laws in force in the State of New South Wales and each party submits to the non-exclusive jurisdiction of the courts of that State.

  
 11 

 Schedule 1 
  

	
	 Benefits
  

  

			
	 Payment in lieu of notice (1 January 2013 to 11 January 2013)*
	  	$6,847.83
	 Redundancy entitlements (1 month salary)
	  	$17,500.00
	 Ex-gratia entitlement (2 months’ salary)
	  	$35,000.00
	 Accrued but unused annual leave
	  	to be determined
		
	 Total cash payment
	  	$59,347.83 plus accrued leave

  

	*	The Company will continue to pay Ian’s normal salary on a monthly basis until 31 December 2012. 

 In
addition to paying Ian the above amount, the Company will vest on 31 December 2012 450,000 options granted to Ian by the Company under the Global Employee Share Option Plan. 

  
 12 

 EXECUTED as a deed 
  

							
	 EXECUTED by Prima Biomed Ltd ACN

009 237 889 in accordance with section
 127 of the
Corporations Act 2001:
	 	 )
 )

)
 )

)
	 		 	
	 /s/ Matthew Lehman
	 		 		 	 /s/ Albert Wong

	Signature of Director	 		 		 	Signature of Director
				
	 Matthew Lehman
	 		 		 	 Albert Wong

	Name of Director	 		 		 	Name of Director
				
	 SIGNED by Ian Edward Bangs in the

presence of:
	 	 )
 )

)
 )

)
	 		 	
		 		 		 	 /s/ Ian Edward Bangs

		 		 		 	Ian Edward Bangs
	 /s/ Weiyoto Ang
	 		 		 	
	Signature of Witness	 		 		 	
				
	 Weiyoto Ang
	 		 		 	
	Name of Witness	 		 		 	

  
 13EX-10.1

 Exhibit 10.1 

SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is entered into as of this 3rd day of September, 2013, by and
between BMR-ROGERS STREET LLC, a Delaware limited liability company (“Landlord”), and IDENIX PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
WHEREAS, Landlord and Tenant entered into that certain Lease dated as of September 25, 2012, as amended by that certain First Amendment to Lease dated as of May 1, 2013 (collectively, and as the same may have been heretofore further
amended, amended and restated, supplemented or modified from time to time, the “Lease”), whereby Tenant leases certain premises (the “Premises”) from Landlord in the building at 320 Bent Street in Cambridge,
Massachusetts (the “Building”); 
 B. WHEREAS, Landlord and Tenant, among other things, desire to modify the Estimated
Phase 3 Commencement Date; and 
 C. WHEREAS, Landlord and Tenant desire to modify and amend the Lease only in the respects and on the
conditions hereinafter stated. 
 AGREEMENT 

NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows: 
 1. Definitions.
For purposes of this Second Amendment, capitalized terms shall have the meanings ascribed to them in the Lease unless otherwise defined herein. The Lease, as amended by this Second Amendment, is referred to herein as the “Amended
Lease.” 
 2. Estimated Phase 3 Commencement Date. Tenant has requested that Landlord amend the Estimated Phase 3
Commencement Date set forth in Section 2.4(c) of the Lease and, subject to the terms and conditions of this Second Amendment, Landlord has agreed to amend such Estimated Phase 3 Commencement Date set forth in Section 2.4(c)
of the Lease. Accordingly, Section 2.4(c) of the Lease is hereby deleted in its entirely and replaced with the following: “(c) Estimated Phase 3 Commencement Date: August 31, 2014”. 

3. Rent for Phase 3 Premises. In consideration for Landlord’s agreement to amend the Estimated Phase 3 Commencement Date, and
notwithstanding anything in the Amended Lease to the contrary (including, but not limited to, Sections 1.2, 2.2, 2.3, 2.4, 9.4, and 16.1 of the Lease and Section 2 of this Second Amendment),
Tenant hereby confirms and agrees that commencing on February 28, 2014 and throughout the Term of the Lease, Tenant shall be responsible for the payment of Base Rent, Operating Expenses, the Property Management Fee

 
and Additional Rent with respect to the Phase 3 Premises, and the cost of utilities (if any) supplied to the Phase 3 Premises. Accordingly, the chart in Section 2.3 of the Lease is
hereby deleted in its entirety and replaced with the following chart: 
  

									
	 Dates
	  	Square
Feet of
Rentable
Area	  	Base Rent per
Square Foot of
Rentable Area	  	Monthly
Base Rent	  	Annual Base
Rent
	 April 1, 2013 – the day immediately prior to the Phase 2 Commencement Date
	  	40,676	  	$56.00 annually	  	$189,821.33	  	$2,277,856.00*
	 Phase 2 Commencement Date – February 27, 2014
	  	40,822	  	$56.00 annually	  	$190,502.67	  	$2,286,032.00*
	 February 28, 2014 – March 31, 2014
	  	46,418	  	$56.00 annually	  	$216,617.33	  	$2,599,408.00*
	 April 1, 2014 – March 31, 2015
	  	46,418	  	$57.68 annually	  	$223,115.85	  	$2,677,390.24  
	 April 1, 2015 – March 31, 2016
	  	46,418	  	$59.41 annually	  	$229,807.78	  	$2,757,693.38  
	 April 1, 2016 – March 31, 2017
	  	46,418	  	$61.19 annually	  	$236,693.12	  	$2,840,317.42  
	 April 1, 2017 – March 31, 2018
	  	46,418	  	$63.03 annually	  	$243,810.55	  	$2,925,726.54  
	 April 1, 2018 – March 31, 2019
	  	46,418	  	$64.92 annually	  	$251,121.38	  	$3,013,456.56  
	 April 1, 2019 – March 31, 2020
	  	46,418	  	$66.87 annually	  	$258,664.31	  	$3,103,971.66  

 * Note:     Amount is based on twelve (12) months. 

4. Use of Phase 3 Premises. Notwithstanding that Tenant shall commence paying Rent with respect to the Phase 3 Premises as of
February 28, 2014, Tenant hereby confirms and agrees that Tenant shall not be permitted to use the Phase 3 Premises until Landlord has completed the Phase 3 Tenant Improvements and the Phase 3 Premises Commencement Date has actually occurred.
In the event that Tenant desires to use the Phase 3 Premises prior to the Estimated Phase 3 Commencement Date (as amended by this Second Amendment) or Tenant no longer desires for Landlord to perform the Phase 3 Tenant Improvements, or both,
Landlord and Tenant shall use commercially reasonable efforts to enter into an express written amendment to the Amended Lease memorializing such change. 

  
 2 

 5. Acknowledgement of Phase 3 Commencement Date. Exhibit D-3 to the Lease is hereby
deleted in its entirety and replaced with Exhibit D-3 attached hereto. 
 6. Phase 3 Tenant Improvements. For the avoidance of
doubt, and in accordance with Section 4.4(a) of the Lease, Landlord hereby confirms that Tenant shall be entitled to a tenant improvement allowance not to exceed One Hundred and 00/100 Dollars ($100.00) per square foot of Rentable Area
of Phase 3 Premises (the “Phase 3 Additional TI Allowance”). Tenant shall request the Phase 3 Additional TI Allowance in accordance with the procedures set forth in Article 4 for the Additional TI Allowance. Landlord shall
not be obligated to expend any portion of the Phase 3 Additional TI Allowance until Landlord shall have received from Tenant a letter in the form attached as Exhibit E-1 hereto executed by an authorized officer of Tenant. Base Rent shall be
increased to include the amount of the Phase 3 Additional TI Allowance disbursed by Landlord in accordance with the Amended Lease amortized over the initial Term at a rate of eight percent (8%) annually. 

7. Broker. Tenant represents and warrants that it has not dealt with any broker or agent in the negotiation for or the obtaining of
this Second Amendment and agrees to indemnify, defend and hold Landlord harmless from any and all cost or liability for compensation claimed by any such broker or agent employed or engaged by it or claiming to have been employed or engaged by it.

 8. No Default. Tenant represents, warrants and covenants that, to the best of Tenant’s knowledge, Landlord and Tenant are not
in default of any of their respective obligations under the Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. 

9. Notices. Tenant confirms that, notwithstanding anything in the Lease to the contrary, notices delivered to Tenant pursuant to the
Amended Lease should be sent to: 
 Idenix Pharmaceuticals, Inc. 

320 Bent Street 
 Cambridge,
Massachusetts 02142 
 Attn: General Counsel 

10. Effect of Second Amendment. Except as modified by this Second Amendment, the Lease and all the covenants, agreements, terms,
provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. The covenants, agreements, terms, provisions and conditions contained in this Second Amendment shall bind and inure to the benefit of the
parties hereto and their respective successors and, except as otherwise provided in the Lease, their respective assigns. In the event of any conflict between the terms contained in this Second Amendment and the Lease, the terms herein contained
shall supersede and control the obligations and liabilities of the parties. From and after the date hereof, the term “Lease” as used in the Lease shall mean the Lease, as modified by this Second Amendment. 

  
 3 

 11. Miscellaneous. This Second Amendment becomes effective only upon execution and
delivery hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Second Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof.
All exhibits hereto are incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or
otherwise until execution by and delivery to both Landlord and Tenant. 
 12. Counterparts. This Second Amendment may be executed in
one or more counterparts, each of which, when taken together, shall constitute one and the same document. 
 [REMAINDER OF THIS PAGE
INTENTIONALLY LEFT BLANK] 

  
 4 

 IN WITNESS WHEREOF, Landlord and Tenant have hereunto set their hands as a sealed Massachusetts
instrument as of the date and year first above written, and acknowledge that they possess the requisite authority to enter into this transaction and to execute this Second Amendment. 

LANDLORD: 
  

			
	 BMR-ROGERS STREET LLC,
 a Delaware
limited liability company

		
	By:	 	/s/ William Kane
	Name:	 	William Kane
	Title:	 	Vice President of Leasing and Development

 TENANT: 
  

			
	 IDENIX PHARMACEUTICALS, INC.,
 a
Delaware corporation

		
	By:	 	/s/ Maria Stahl
	Name:	 	Maria Stahl
	Title:	 	SVP and General Counsel

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