Document:

Exhibit 4.2

IMINCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARECUSIP 999999
99 9SEE REVERSE FOR CERTAIN DEFINITIONS AND LEGENDSThis certifies thatis the record holder ofFULLY PAID AND NONASSESSABLE SHARES
OF COMMON STOCK, $0.0001 PAR VALUE PER SHARE, OF Immunome, Inc. transferable on the books of the Corporation in person or by duly
authorized attorney upon surrender of this Certificate properly endorsed. This Certificate is not valid until countersigned by
the Transfer Agent and registered by the Registrar.WITNESS the facsimile seal of the Corporation and the facsimile signatures
of its duly authorized officers.Dated:PRESIDENTSEAL December 2, 2015SECRETARY

    

     

    

The Corporation shall furnish without charge to each stockholder
who so requests a statement of the powers, designations, preferences and relative, participating, optional or other special rights
of each class of stock of the Corporation or series thereof and the qualifications, limitations or restrictions of such preferences
and/or rights. Such requests shall be made to the Corporation’s Secretary at the principal office of the Corporation.KEEP
THIS CERTIFICATE IN A SAFE PLACE. IF IT IS LOST, STOLEN,OR DESTROYED THE CORPORATION WILL REQUIRE A BOND INDEMNITY AS A CONDITION
TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE.The following abbreviations, when used in the inscription on the face of this certificate,
shall be construed as though they were written out in full according to applicable laws or regulations:TEN COM – as tenants
in common TEN ENT – as tenants by the entireties JT TEN – as joint tenants with right of survivorship and not as tenants
in common COM PROP – as community propertyUNIF GIFT MIN ACT – ......................... Custodian .........................
(Cust) (Minor) under Uniform Gifts to Minors Act..............................................................................
(State) UNIF TRF MIN ACT – ................. Custodian (until age ..................) (Cust) .....................................
under Uniform Transfers (Minor) to Minors Act............................................................ (State)Additional abbreviations
may also be used though not in the above list.FOR VALUE RECEIVED, hereby sell(s), assign(s) and transfer(s) untoPLEASE INSERT
SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)shares
of the capital stock represented by within Certificate, and do hereby irrevocably constitute and appointattorney-in-fact to transfer
the said stock on the books of the within named Corporation with full power of the substitution in the premises.DatedSignature(s)
Guaranteed:X X NOTICE: THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE
IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATSOEVER.By THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN
ELIGIBLE GUARANTOR INSTITUTION, (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED
SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15. GUARANTEES BY A NOTARY PUBLIC ARE NOT ACCEPTABLE. SIGNATURE
GUARANTEES MUST NOT BE DATED.Exhibit 4.4

 

AMENDMENT TO

2020 SERIES A PREFERRED
STOCK WARRANTS

 

THIS AMENDMENT (this “Amendment”)
is entered into effective as of September 20, 2020 by and among Immunome, Inc. (the “Company”), a Delaware corporation,
and the undersigned holders of Warrants (defined below) (the “Holders”). This Amendment amends the 2020 Series A Preferred
Stock Purchase Warrants issued pursuant to the 2020 Series A Preferred Stock Purchase Agreement dated as of June 2, 2020 among
the Company and the purchasers who are parties thereto, as amended (the “Warrants”). All capitalized terms used in
this Amendment without definition shall have the respective meanings assigned to them in the Warrants.

 

Background:

 

The Company and the Holders wish to amend
all of the Warrants to include “net exercise” mechanics as provided below. The Holders hold Warrants sufficient to
satisfy the foregoing requirement to amend the Warrants and, by virtue of the execution and delivery of this Amendment, the agreements
in this Amendment will apply to and be binding upon the Company and all of the holders of Warrants.

 

NOW,
THEREFORE, in consideration of the premises and covenants set forth herein, and
intending to be legally bound hereby, the parties hereto agree as follows:

 

1.       
Amendment to Section 1 of Warrants.1. Section 1 of the Warrants is hereby amended to include
the following new Section 1(d) thereto, immediately following Section 1(c):

 

(d)       Net
Issuance Exercise. Notwithstanding anything to the contrary set forth herein, Holder may, at Holder’s election, exercise
this Warrant by either (i) paying to the Company an amount equal to the aggregate Warrant Price of the shares being purchased or
(ii) receiving shares of Preferred Stock equal to the value (as determined below) of this Warrant, in which event the Company
shall issue to Holder a number of shares of Preferred Stock computed using the following formula:

 

X = Y(A-B)

A

 

Where:              X =       the number of shares to be issued
to Holder

 

Y =       the total
number of shares purchasable under this Warrant

 

A =       the
Current Fair Market Value of one share of Preferred Stock

 

B =       the Warrant
Price then in effect

 

As used herein, “Current Fair Market Value of
Preferred Stock” with respect to each share of Preferred Stock means the following, as applicable:

 

(i)       If
this Warrant is being exercised in conjunction with and effective upon the initial public offering of the Company’s Common
Stock pursuant to a registration statement filed under the Securities Act of 1933, as amended (the “IPO”), then
the Current Fair Market Value shall be the price at which the Common Stock is sold to the public in the IPO;

 

     

     

    

 

(ii)       If
this Warrant is being exercised after the IPO, at any time the Company’s Common Stock is listed on any domestic securities
exchange, then the Current Fair Market Value shall be (A) the volume weighted average of the closing sales prices of the Common
Stock for the business day preceding the exercise day on all domestic securities exchanges on which the Common Stock may at the
time be listed or (B) if there have been no sales of the Common Stock on any such exchange on any such business day, the average
of the highest bid and lowest asked prices for the Common Stock on all such exchanges at the end of such business day; and

 

(iii)       If
neither (i) or (ii) is applicable, then the Current Fair Market Value shall be the fair market value per share as determined by
the Board of Directors of the Company.

 

2.            
Amendment to Section 1(a) of Warrants.2. Section 1(a) of the Warrants is hereby amended
and restated in its entirety to provide as follows:

 

(a)       Exercise
Procedures. Holder may exercise this Warrant, in whole or in part, by presentation and surrender of this Warrant to the Company
with the Form of Subscription attached hereto duly executed and accompanied by payment of the full Warrant Price for each share
to be purchased paid by cash, check, wire transfer, net exercise as provided in this Warrant or any combination of the foregoing.

 

3.            
Amendment to Section 7.3. Section 7 of the Warrants is hereby amended to remove the final
sentence thereof (the original definition of “Current Fair Market Value”).

 

4.            
Amendment to Form of Subscription.4. The Form of Subscription attached to the Warrants
is amended and restated so as to provide as set forth on the attached Form of Subscription.

 

5.            
Confirmation. Pursuant to Section 4 of the Warrants, upon the conversion of all outstanding
shares of Preferred Stock into Common Stock, the Warrants shall thereupon become exercisable for shares of Common Stock instead
of Preferred Stock, and the Warrants are hereby amended to give effect thereto. Without limitation of the effectiveness of the
preceding sentence, the Board of Directors is authorized to prepare such documents as it deems necessary or appropriate to further
document the foregoing.

 

6.            
Effect of Amendment.5. The parties acknowledge and agree that all of the terms, provisions,
covenants and conditions of the Warrants shall hereafter continue in full force and effect in accordance with the terms thereof,
except to the extent expressly modified, amended or revised herein; provided, however, that if any term or provision of this Amendment
shall conflict with or otherwise be inconsistent with any term or provision of any of the Warrants, the terms and provisions of
this Amendment shall prevail.

 

7.           
Governing Law.6. This Amendment shall be governed by and construed under the laws of the
State of Delaware, without giving effect to principles of conflicts of laws.

 

8.           
Counterparts.7. This Amendment may be executed (including by facsimile, PDF or other electronic
means) in two or more counterparts, each of which shall be deemed an original, and all of which together shall constitute one and
the same instrument.

 

(Signature pages follow.)

 

    2 

     

    

 

IN WITNESS WHEREOF, the parties hereto have
executed this Amendment as of the date first above written.

 

	 	IMMUNOME, INC.
	 	 
	 	By:	 
	 	 	Name: Purnanand Sarma
	 	 	Title: CEO and President

 

     

     

    

 

IN WITNESS WHEREOF, the undersigned has
caused this Amendment to be executed as of the date first above written.

 

	 	Individuals Sign Below:
	 	 
	 	Signature
	 	 
	 	Name
	 	 
	 	Signature (if more than one)*
	 	 
	 	Name (if more than one)*

 

	 	Corporations, Trusts, Partnerships, Limited

                           Liability Companies, Retirement Plans,

                           Retirement Accounts or Other Entities Sign

                           Below:

	 	 
	 	Name of Entity
	 	 
	 	By:	 
	 	 	Signature
	 	 
	 	Name and Title of Signatory

 

*If joint holders, both must sign.

 

     

     

    

 

FORM OF SUBSCRIPTION

 

(1)       The
undersigned hereby elects to purchase ________ shares of ________ Stock of Immunome, Inc. (the “Company”) pursuant
to the terms of the attached Warrant, and tenders herewith payment of the exercise price in full, together with all applicable
transfer taxes, if any.

 

(2)       The
undersigned hereby elects to purchase ________ shares of ________ Stock of the Company pursuant to the terms of the net exercise
provisions set forth in Section 1(d) of the attached Warrant, and shall tender payment of all applicable transfer taxes, if
any.

 

(3)       Please
issue a certificate or certificates representing said shares (the “Shares”) in the name of the undersigned or in such
other name as is specified below:

 

________________________

(Name)

 

_______________________

 

________________________

(Address)

 

(4)       The
undersigned represents and warrants that (a) the undersigned is an “accredited investor” within the meaning of
Rule 501 under the Securities Act of 1933, as amended (the “Securities Act”) and (b) the undersigned will
acquire the Shares for the undersigned’s own account and that the Shares are being and will be acquired by the undersigned
for the purpose of investment and not with a view to distribution or resale thereof. The undersigned further represents and warrants
that the undersigned understands and agrees that, until registered under the Securities Act or transferred pursuant to the provisions
of Rule 144 as promulgated by the Securities and Exchange Commission, all certificates evidencing any of the Shares shall
bear a legend, prominently stamped or printed thereon, reading substantially as follows:

 

“THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE
NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 OR APPLICABLE STATE SECURITIES LAWS. THESE SECURITIES HAVE BEEN ACQUIRED FOR
INVESTMENT AND NOT WITH A VIEW TO DISTRIBUTION OR RESALE, AND MAY NOT BE SOLD, MORTGAGED, PLEDGED, HYPOTHECATED OR OTHERWISE TRANSFERRED
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT FOR SUCH SECURITIES UNDER THE SECURITIES ACT OF 1933 AND APPLICABLE STATE SECURITIES
LAWS, OR THE AVAILABILITY OF AN EXEMPTION FROM THE REGISTRATION PROVISIONS OF THE SECURITIES ACT OF 1933 AND APPLICABLE STATE SECURITIES
LAWS.”

 

	 	 	(Print name of Holder)
	 	 	 
	 	 	By:	       
	(Date)	 	(Sign above)
	 	 	 
	 	 	(Print name of and title of signatory, if applicable)

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