Document:

Exhibit 10.4.1

 

June 26, 2014

 

		Re:	PAXmed Inc.

 

Gentlemen:

 

Reference is made to those certain warrants (“Warrants”)
to purchase shares of common stock, par value $0.001 (“Common Stock”), of PAXmed Inc. (“Company”) held
by the undersigned.

 

The Company hereby acknowledges and agrees that,
so long as the Warrants are held by the undersigned or its permitted transferees (as defined in the registration statement for
the Company’s initial public offering), the Company shall allow the undersigned to exercise the Warrants by surrendering
such Warrant for that number of shares of Common Stock equal to the quotient obtained by dividing (x) the product of the number
of shares of Common Stock underlying the Warrant, multiplied by the difference between the exercise price of the Warrants and the
“Fair Market Value” (defined below) by (y) the Fair Market Value; provided, however, that no cashless exercise shall
be permitted unless the Fair Market Value is higher than the exercise price of the Warrants. The “Fair Market Value”
shall mean the average reported last sale price of the Common Stock for the 10 trading days ending on the day prior to the Company’s
receipt of the applicable exercise notice. Notwithstanding anything to the contrary herein, the Company shall not be required to
net-cash settle the Warrants.

 

	 	 	Very truly yours,
	 	 	 
	 	 	PAXMED INC.
	 	 	 
	 	 	 
	 	By:	/s/ Lishan Aklog, MD
	 	 	Name:	Lishan Aklog, MD
	 	 	Title: 	Chairman & CEO

 

ACCEPTED AND AGREED:

 

HCFP CAPITAL PARTNERS III LLC

 

 

	By:	/s/ Lishan Aklog, MD	 
	 	Name:	Lishan Aklog, MD	 
	 	Title: 	ManagerExhibit 10.4.2

 

June 26, 2014

 

		Re:	PAXmed Inc.

 

Gentlemen:

 

Reference is made to those certain warrants (“Warrants”)
to purchase shares of common stock, par value $0.001 (“Common Stock”), of PAXmed Inc. (“Company”) held
by the undersigned.

 

The Company hereby acknowledges and agrees that,
so long as the Warrants are held by the undersigned or its permitted transferees (as defined in the registration statement for
the Company’s initial public offering), the Company shall allow the undersigned to exercise the Warrants by surrendering
such Warrant for that number of shares of Common Stock equal to the quotient obtained by dividing (x) the product of the number
of shares of Common Stock underlying the Warrant, multiplied by the difference between the exercise price of the Warrants and the
“Fair Market Value” (defined below) by (y) the Fair Market Value; provided, however, that no cashless exercise shall
be permitted unless the Fair Market Value is higher than the exercise price of the Warrants. The “Fair Market Value”
shall mean the average reported last sale price of the Common Stock for the 10 trading days ending on the day prior to the Company’s
receipt of the applicable exercise notice. Notwithstanding anything to the contrary herein, the Company shall not be required to
net-cash settle the Warrants.

 

	 	 	Very truly yours,
	 	 	 
	 	 	PAXMED INC.
	 	 	 
	 	 	 
	 	By:	/s/ Lishan Aklog, MD
	 	 	Name:	Lishan Aklog, MD
	 	 	Title: 	Chairman & CEO

 

ACCEPTED AND AGREED:

 

PAVILION VENTURE PARTNERS LLC

 

 

	By:	/s/ Lishan Aklog, MD	 
	 	Name:	Lishan Aklog, MD	 
	 	Title: 	ManagerExhibit
10.5.1

 

	 	April 8, 2015

 

PAXmed, Inc.

420 Lexington
Avenue, Suite 300

New York, New
York 10170

 

CRT Capital
Group LLC

262 Harbor Drive

Stamford, Connecticut
06902

 

Re:        Initial Public
Offering

 

Gentlemen:

 

This letter is being delivered
to you in connection with the initial public offering (“IPO”) of PAXmed Inc. (the “Company”) to be underwritten
by several underwriters for whom CRT Capital Group LLC will serve as representative (collectively, the “Underwriters”).  In
order to induce the Company and the Underwriters to proceed with the IPO, and in recognition of the benefit that such IPO will
confer upon the undersigned as beneficial owner of securities of the Company, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the undersigned hereby agrees as follows:

 

1.          In
order to minimize potential conflicts of interest which may arise from multiple affiliations, until such time as the undersigned
ceases to be an officer of the Company, he will present to the Company for its consideration, prior to presentation to any other
person or entity, any suitable business opportunity which may be reasonably required to be presented to the Company, subject to
any pre-existing fiduciary and contractual obligations the undersigned might have.

 

2.          The
undersigned has full right and power, without violating any agreement by which he is bound, to enter into this letter agreement.

 

3.          This
letter agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York, without
giving effect to conflicts of law principles that would result in the application of the substantive laws of another jurisdiction.  The
undersigned hereby (i) agrees that any action, proceeding or claim against him arising out of or relating in any way to this letter
agreement (a “Proceeding”) shall be brought and enforced in the courts of the State of New York of the
United States of America for the Southern District of New York, and irrevocably submits to such jurisdiction, which jurisdiction
shall be exclusive, (ii) waives any objection to such exclusive jurisdiction and that such courts represent an inconvenient

 

    	 

    	 

    

 

forum and (iii) irrevocably agrees to appoint
Graubard Miller as agent for the service of process in the State of New York to receive, for the undersigned and on his behalf,
service of process in any Proceeding.  

 

4.          The
undersigned acknowledges and understands that the Underwriters and the Company will rely upon the agreements, representations and
warranties set forth herein in proceeding with the IPO.

 

	 	Lishan Aklog
	 	Print Name
	 	 
	 	/s/ Lishan Aklog
	 	Signature

 

    	2Exhibit
10.5.2

 

	 	April 13, 2015

 

PAXmed, Inc.

420 Lexington
Avenue, Suite 300

New York, New
York 10170

 

CRT Capital
Group LLC

262 Harbor Drive

Stamford, Connecticut
06902

 

Re:         Initial Public
Offering

 

Gentlemen:

 

This letter is being delivered
to you in connection with the initial public offering (“IPO”) of PAXmed Inc. (the “Company”) to be underwritten
by several underwriters for whom CRT Capital Group LLC will serve as representative (collectively, the “Underwriters”).  In
order to induce the Company and the Underwriters to proceed with the IPO, and in recognition of the benefit that such IPO will
confer upon the undersigned as beneficial owner of securities of the Company, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the undersigned hereby agrees as follows:

 

1.           In order to minimize
potential conflicts of interest which may arise from multiple affiliations, until such time as the undersigned ceases to be an
officer of the Company, he will present to the Company for its consideration, prior to presentation to any other person or entity,
any suitable business opportunity which may be reasonably required to be presented to the Company, subject to any pre-existing
fiduciary and contractual obligations the undersigned might have.

 

2.           The undersigned has
full right and power, without violating any agreement by which he is bound, to enter into this letter agreement.

 

3.           This letter agreement
shall be governed by and construed and enforced in accordance with the laws of the State of New York, without giving effect to
conflicts of law principles that would result in the application of the substantive laws of another jurisdiction.  The
undersigned hereby (i) agrees that any action, proceeding or claim against him arising out of or relating in any way to this letter
agreement (a “Proceeding”) shall be brought and enforced in the courts of the State of New York of the
United States of America for the Southern District of New York, and irrevocably submits to such jurisdiction, which jurisdiction
shall be exclusive, (ii) waives any objection to such exclusive jurisdiction and that such courts represent an inconvenient

 

    	 

    	 

    

 

forum and (iii) irrevocably agrees to appoint
Graubard Miller as agent for the service of process in the State of New York to receive, for the undersigned and on his behalf,
service of process in any Proceeding.  

 

4.           The undersigned acknowledges
and understands that the Underwriters and the Company will rely upon the agreements, representations and warranties set forth herein
in proceeding with the IPO.

 

	 	Michael Glennon
	 	Print Name
	 	 
	 	/s/ Michael Glennon
	 	Signature

 

    	2Exhibit
10.5.3

 

	 	April 7, 2015

 

PAXmed, Inc.

420 Lexington
Avenue, Suite 300

New York, New
York 10170

 

CRT Capital
Group LLC

262 Harbor Drive

Stamford, Connecticut
06902

 

Re:        Initial Public
Offering

 

Gentlemen:

 

This letter is being delivered
to you in connection with the initial public offering (“IPO”) of PAXmed Inc. (the “Company”) to be underwritten
by several underwriters for whom CRT Capital Group LLC will serve as representative (collectively, the “Underwriters”).  In
order to induce the Company and the Underwriters to proceed with the IPO, and in recognition of the benefit that such IPO will
confer upon the undersigned as beneficial owner of securities of the Company, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the undersigned hereby agrees as follows:

 

1.          In
order to minimize potential conflicts of interest which may arise from multiple affiliations, until such time as the undersigned
ceases to be an officer of the Company, he will present to the Company for its consideration, prior to presentation to any other
person or entity, any suitable business opportunity which may be reasonably required to be presented to the Company, subject to
any pre-existing fiduciary and contractual obligations the undersigned might have.

 

2.          The
undersigned has full right and power, without violating any agreement by which he is bound, to enter into this letter agreement.

 

3.          This
letter agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York, without
giving effect to conflicts of law principles that would result in the application of the substantive laws of another jurisdiction.  The
undersigned hereby (i) agrees that any action, proceeding or claim against him arising out of or relating in any way to this letter
agreement (a “Proceeding”) shall be brought and enforced in the courts of the State of New York of the
United States of America for the Southern District of New York, and irrevocably submits to such jurisdiction, which jurisdiction
shall be exclusive, (ii) waives any objection to such exclusive jurisdiction and that such courts represent an inconvenient

 

    	 

    	 

    

 

forum and (iii) irrevocably agrees to appoint
Graubard Miller as agent for the service of process in the State of New York to receive, for the undersigned and on his behalf,
service of process in any Proceeding.  

 

4.          The
undersigned acknowledges and understands that the Underwriters and the Company will rely upon the agreements, representations and
warranties set forth herein in proceeding with the IPO.

 

	 	Brian J. deGuzman, MD
	 	Print Name
	 	 
	 	/s/ Brian J. deGuzman
	 	Signature

 

    	2

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