Document:

EX-10.15

 Exhibit 10.15 

FIRST AMENDED AND RESTATED SUPPLY AGREEMENT 

This Amended and Restated Supply Agreement (this “Agreement”) is entered into as of June 25, 2014 (the “A&R
Effective Date”) by and between RainDance Technologies, Inc., a Delaware corporation, with principal offices at 749 Middlesex Turnpike, Billerica, MA 01821 (“Supplier”) and Myriad Genetic Laboratories Inc., a Delaware
corporation, with principal offices at 320 Wakara Way, Salt Lake City, Utah 84108 (“Customer”). 
 WHEREAS, Supplier and
Customer entered into that certain Supply Agreement, dated April 12, 2013 (the original date of such agreement, the “Effective Date” and such agreement, the “Supply Agreement”) and amended by that certain
Amendment 1 to Supply Agreement, dated September 16, 2013 (such amendment, “Amendment 1”); 
 WHEREAS, Supplier
manufactures and sells the ThunderStormTM instrument, a fully automated targeted sequencing solution more fully described in Exhibit A attached hereto (the “Instrument”); 

WHEREAS, Supplier manufactures and sells custom libraries (the “Customer Libraries”) and chips, reagents and other
consumables for use with the Instrument (the “Other Consumables” and together with the Customer Libraries, the “Consumables”) more fully described in Exhibit B attached hereto; 

[****]; 
 WHEREAS, Customer
intends to purchase the Instruments, Customer Libraries, the Other Consumables (collectively, the “Products”), Service Contracts (as defined below), and the [****], all from Supplier on the terms and conditions set forth herein;

 WHEREAS, Supplier and Customer have been engaged in and desire to continue to engage in joint research and development efforts that allow
enhanced configurations of certain of Supplier’s instruments to provide better utilization of Customer’s Libraries; and 

WHEREAS, Supplier and Customer desire to amend and restate the Supply Agreement and Amendment 1 on the terms and conditions set forth herein.

 NOW THEREFORE, in consideration of the mutual promises herein set forth and other good and valuable consideration, the parties agree as
follows: 
 1. Purchase of Products 

a. Purchase of Instruments. Customer agrees to purchase, and Supplier agrees to sell, the Instruments at the purchase price set forth in
Exhibit D attached hereto, and in accordance with the terms herein. [****] (as defined below). The Instruments will be delivered along with the then-generally available associated user manuals, instructions for use and related documentation
(the “System Documentation”). 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (i) Instrument Specifications. Supplier shall manufacture the Instruments to the
specifications set forth in Exhibit A (“Instrument Specifications”). Supplier shall not change the Instrument Specifications, without Customer’s prior written consent. 

(ii) Instrument Warranty. Supplier represents and warrants that each Instrument shall be free from material defects and conform to the
Instrument Specifications for the period beginning with delivery and ending with successful completion of the Performance Qualification (“PQ”) of such Instrument as set forth in Exhibit A. Supplier shall be responsible for the
installation of each Instrument. 
 (iii) Service Contracts. Customer agrees to purchase and Supplier agrees to sell annual
Instrument service contracts, as more fully described in Exhibit E attached hereto (the “Service Contracts”), at the price set forth in Exhibit E. The term of each Service Contract shall be for one year commencing on
the date that the System Acceptance Test for such Instrument as set forth in Exhibit A has been successfully completed. Each ensuing annual Service Contract for each Instrument will have a term of one year commencing on the expiration of the
term of the preceding annual Service Contract. [****]. However, if there is less than one year left remaining of the Term of this Agreement, then the renewal price for any annual Service Contract shall be prorated based on the remaining days left in
the Term of this Agreement. Customer shall purchase a Service Contract annually for each Instrument for each year of the Term. The first Service Contract for each Instrument shall be invoiced at the time Supplier invoices Customer for each
Instrument and Customer shall pay for Service Contracts in accordance with the terms of Section 2.d. Further, in the event Customer decommissions an Instrument, Customer shall no longer be required to purchase Service Contracts for such
Instrument and Supplier shall have no further service obligations with respect to such Instrument. Service Contracts do not obligate Supplier to resolve issues that arise from the handling, storage, modification or use of an Instrument by Customer
in a manner that does not comply with the System Documentation and Supplier’s written protocols, procedures, technical bulletins and other correspondences. However, if Supplier elects to not resolve issues that arise under the foregoing
sentence, and the Supplier is not servicing the material operational aspects of such Instrument covered by a Service Contract, then Customer will not be obligated to renew the applicable Service Contract. 

(iv) Commitment to Purchase Instruments. Notwithstanding anything herein to the contrary, Customer hereby irrevocably agrees to order
and, in accordance with Section 2.g(iii), accept [****] additional Instruments between the A&R Effective Date and [****], and each such Instrument shall be ordered and accepted no later than the corresponding dates set forth below:

  

			
	 Additional Number

of Instruments
	  	 Deadline for

Acceptance

	[****]	  	[****]
	[****]	  	[****]
	[****]	  	[****]
	[****]	  	[****]
	[****]	  	[****]
	[****]	  	[****]

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 For clarity, such Instruments are in addition to the Instruments ordered by Customer prior to the A&R
Effective Date. Customer may advance the ordering and acceptance schedule with respect to the additional Instruments. However and notwithstanding anything to the contrary set forth in this Agreement, if the deadline for ordering and accepting (as
set out in the preceding table) any such additional Instruments passes and Customer has not ordered and accepted the appropriate number of Instruments, (1) Customer shall be deemed to have ordered and accepted such Instruments,
(2) Supplier shall sell and deliver the same to Customer as if Customer had ordered and accepted such Instruments, and (3) Customer shall pay for the same in accordance with Section 2.d(ii). With respect to Instruments
delivered under this Section 1.a.iv, Customer shall only be liable to pay for Instruments that conform to the requirements set forth in Section 1.a.ii. For clarity, Customer’s failure to order and accept the Instruments in a
timely manner in accordance with the schedule set forth above shall not excuse Customer from paying for such Instruments, unless the failure to meet the specified date is the direct result of Supplier’s failure to comply with
Section 2.g(iii). In the event of such failure by Supplier, the corresponding schedule set forth above shall be extended only for the period of time such failure by Supplier continues. 

b. Purchase of Consumables. Customer agrees to purchase and Supplier agrees to sell the Consumables for use with the Instruments at the
purchase prices set forth in Exhibit D, [****], and in accordance with the terms herein. [****]. The Consumables will be delivered along with the then-generally available instructions for handling and use (the “Consumables
Documentation”). 
 (i) Consumable Specifications. Supplier shall manufacture the Customer Libraries to the specifications
included in Exhibit B (the “Library Specifications”); provided that Customer shall bear full responsibility to ensure that the Library Specifications accurately describe the components and nucleic acid sequences that are
desired. Supplier shall manufacture the Other Consumables to the specifications included in Exhibit B (the “Other Consumables Specifications” and together with the Library Specifications, the “Consumables
Specifications”). Supplier shall not change the Consumables Specifications, including but not limited to, the materials, design/configuration, packaging or labeling without Customer’s prior written consent. Any changes to the Library
Specifications proposed by Customer during the Term shall be conveyed to Supplier in writing. Supplier shall confirm in writing its receipt of Customer’s proposed changes and notify Customer whether and to the extent such proposed changes can
be manufactured by the Supplier, [****]. Supplier shall use its commercially reasonable efforts to accept and implement any Customer proposed changes to the Library Specifications. Any increase in Supplier’s production costs shall be supported
by documentation in form and content reasonably satisfactory to Customer. If Customer elects to adopt the proposed changes, the price schedule for the affected Consumables shall be amended to reflect any increase in Supplier’s costs ([****]).
For clarity, consumables that are requested by Customer for supply by Supplier that do not conform to the Consumables Specifications are not governed by the terms of this Agreement (for example, research or experimental products) and, without
limiting the foregoing, Supplier’s failure to supply consumables that do not conform to the Consumables Specifications shall not give rise to any remedies hereunder. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (ii) Consumables Warranty. Supplier represents and warrants that all (A) Customer
Libraries shall be free from material defect and conform with the applicable Consumables Specification for [****] and (B) Other Consumables shall be free from material defect and conform with the applicable Consumables Specifications for a
period of [****]. The foregoing warranty shall not apply to any Consumables (i) that are handled, stored, modified or used by Customer other than in accordance with the System Documentation, Consumables Documentation and Supplier’s written
protocols, procedures, technical bulletins and other correspondences which have been agreed to by the Steering Committee, or (ii) in respect of which the nonconformance resulted from Customer’s upstream or downstream usage of the
Consumables (outside of what otherwise is normal contemplated use), including, but not limited to, using single-use Consumables more than once. [****]. The parties will use commercially reasonable efforts to [****] and will in good faith
correspondingly modify the applicable Library Specifications and the warranty period under Section 1.b.(ii)(A). Also, the parties will in good faith establish the Functional Performance Specifications of the Library Specifications [****]
of first delivery of Customer Library to Customer. 
 (iii) [****]. As of the Effective Date, the [****] are [****]. However, during the
Term, [****]. If [****] will promptly [****] and [****] including [****]. [****] to [****] and [****]. For clarity, [****]. Further, in the event [****] the [****]. Customer hereby represents and warrants to Supplier that [****] 

2. Forecasts; Terms and Conditions of Purchase of Products and Service Contracts 

a. Forecasts. 
 (i) On
[****] and on or about each [****] and [****] between the [****] and [****], Customer shall provide to Supplier (by email to the attention of Supplier’s Sales Administrator and Director of Manufacturing, with a copy to Business Leader,
Sequencing) 12-month forecasts (by month) of its requirements for each of the Products in the format reasonably requested by Supplier (the “Forecasts”). Supplier shall provide the recipient email addresses from time to time (by
email to the attention of Customer’s VP of Operations with a copy to Director of Purchasing) and Customer acknowledges that such new email addresses shall be effective upon receipt from Supplier regardless of Section 11.a. The
initial Forecast is set forth in Exhibit F attached hereto (the “Initial Forecast”) and shall be deemed to be the [****] forecast for purposes of [****]. The first six (6) months of each such Forecast provided in [****]
shall constitute a binding obligation to purchase the specified Products (the “Binding Forecast”) to the extent that the specified Product being ordered is within production lead times. The second six (6) months of each such Binding
Forecast shall be non-binding (the “Non-Binding Forecast”). The Forecasts provided in [****] are for discussion purposes only and will not amend the then-current Binding Forecast. Each Binding Forecast will be accompanied by a
purchase order (a “Purchase Order”) describing the terms, dates and delivery schedule for such purchases. Supplier shall accept each Purchase Order that complies with a Binding Forecast and the other terms of this Agreement.
Supplier will use commercially reasonable efforts to supply Products ordered by Customer that are in addition to those required by the then-current Binding Forecast. For clarity, the then-current Binding Forecast shall lock in prices for the period
of such Binding Forecast such that any additional Consumables ordered by Customer and supplied by Supplier during the period of such Binding Forecast shall be ordered and sold at the relevant price indicated by such Binding Forecast in accordance
with this Agreement. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (ii) Beginning on [****] and on or about each subsequent [****] and [****] during the Term of
this Agreement, Customer shall provide to Supplier (by email to the attention of Supplier’s Sales Administrator and Director of Manufacturing, with a copy to Business Leader, Sequencing) 12-month forecasts (by month) of its requirements for
each of the Products in the format reasonably requested by Supplier and each such forecast shall constitute a binding obligation to purchase the specified amount and type of Products (the “Binding Forecast”) to the extent that the
specified Product being ordered is within production lead times. For clarity, the Binding Forecast provided on or about the A&R Effective Date shall be for the period beginning [****] and [****] (inclusive), the Binding Forecast provided on or
about [****] shall be for the period beginning [****] and [****] (inclusive), and subsequent Binding Forecasts shall follow in like manner. Supplier shall provide the recipient email addresses from time to time (by email to the attention of
Customer’s VP of Operations with a copy to Director of Purchasing) and Customer acknowledges that such new email addresses shall be effective upon Customer’s confirmation of receipt from Supplier regardless of Section 11.a.
Each Binding Forecast required by this Section 2.a(ii) will be accompanied by a purchase order (a “Purchase Order”) for any Products required for the first six (6) months of such Binding Forecast, including any
Instruments required to be purchased by Customer during such six (6) month period in accordance with Section 1.a(iv). The Purchase Orders shall describe the terms, dates and delivery schedule for such purchases in accordance
with the terms of this Agreement. Supplier shall accept each Purchase Order that complies with a Binding Forecast and the other terms of this Agreement. [****]. 

b. Lead Times. Deliveries will be scheduled according to a mutually acceptable schedule with the expectation that deliveries would be
made within the applicable lead times set forth in Exhibits A, B and C, except in the case where the forecast demand exceeds [****] of the prior forecast. Customer acknowledges such lead-times and Customer agrees to forecast and order Products
accordingly. 
 c. Meetings. Promptly following receipt of a Non-Binding or Binding Forecast from Customer in accordance with
Section 2.a, Supplier and Customer shall discuss the following: (i) [****] and (ii) whether Customer anticipates requesting changes to the Customer Library. 

d. Payment Terms; Taxes. 

(i) At the time of submission of a Purchase Order between the Effective Date and prior to the A&R Effective Date, Customer shall pay
[****] of the total purchase price set forth in such Purchase Order for Instruments, the first Service Contracts for such Instruments, and Consumables and Customer shall pay the balance of such purchase price for Instruments, the first Service
Contracts for such Instruments, and Consumables [****] following delivery and installation (as applicable) relating to the applicable Purchase Order. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (ii) At the time of submission of a Purchase Order on or after the A&R Effective Date,
Customer shall pay [****] set forth in each such Purchase Order for Instruments, the first Service Contracts for such Instruments, Consumables, in each case for Product to be delivered and Service Contracts to be purchased during the six (6)-month
period immediately following the date of such Purchase Order. Customer shall pay the balance of such purchase price for Instruments, the first Service Contracts for such Instruments, and Consumables [****] following delivery and installation (as
applicable) relating to the applicable Purchase Order. 
 e. Subsequent Service Contracts. Customer shall pay for additional Service
Contracts in full within [****] following the commencement of each such additional subsequent Service Contract. Supplier shall notify Customer of a Service Contract that is about to come due for renewal not less than sixty (60) days prior to
the expiration thereof. 
 f. Delivery and Title. 

(i) Consumables. Supplier shall ship Consumables to the destination(s) specified by Customer on the applicable Purchase Order, utilizing the
carrier, forwarders and brokers specified by Customer. Customer shall be responsible for the cost of shipment and insuring the Consumables in transit. Supplier shall provide lot number tracking. In the event Consumables are shipped to a Customer
location outside of the United States, Customer will be responsible for satisfying all related regulatory obligations and duties. Supplier shall pack all Consumables per standard operating procedure for the designated carrier. All orders will be
shipped with appropriate shipping documentation and clearly marked with the order number and quantity of Consumables. Supplier shall deliver the Consumables on the delivery date specified on the applicable Purchase Order, but shall not be liable for
any delay in delivery caused by the carrier or regulatory agencies, unless such delay is due to any negligence on the part of Supplier. Title to and risk of loss with respect to Consumables shall pass to Customer upon delivery by Supplier to a
common carrier. 
 (ii) Instruments. Supplier shall ship Instruments to the destination(s) specified by Customer on the applicable Purchase
Order, the carrier, forwarders and brokers specified by Supplier. Customer shall be notified of the cost for shipment and insurance coverage for all Instruments to be shipped to Customer, and Customer shall be responsible for all reasonable costs of
shipment and insuring the Instruments in transit. Supplier shall provide lot number tracking. In the event Instruments are shipped to a Customer location outside of the United States, Customer will be responsible for satisfying all related
regulatory obligations and duties. Supplier shall pack all Instruments per standard operating procedure for the designated carrier. All orders will be shipped with appropriate shipping documentation and clearly marked with the order number and
quantity of Instruments. Supplier shall deliver the Instruments on the delivery date specified on the applicable Purchase Order, but shall not be liable for any delay in delivery caused by the carrier or regulatory agencies, unless such delay is due
to any negligence on the part of Supplier. Title to and risk of loss with respect to Instruments shall pass to Customer upon successful completion of the System Acceptance Test. 

g. Inspection and Acceptance. The following shall apply in regard to inspection and acceptance of Products: 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (i) Each shipment shall be accompanied by a certificate of conformance indicating that the
shipment conforms to all relevant Specifications. 
 (ii) Promptly upon receipt of any Consumables, Customer shall inspect the same to check
for any incorrect quantity and shall notify Supplier in writing (or by email) within [****] days of receipt of such Consumables stating any incorrect quantity. 

(iii) With regards to Instruments, Supplier shall perform installation procedures to verify the Instrument conforms to the Specifications in
accordance with Exhibit A. Further, an Instrument shall be deemed delivered and installed upon passing the Systems Acceptance Test. 

(iv) During the applicable warranty period, Customer shall notify Supplier in writing of any variances from the applicable specification that
is reasonably apparent on physical inspection (each notice, a “Non-Conformity Notice”); any Product that is not the subject of a timely Non-Conformity Notice shall be deemed to comply with this Agreement in all respects as to any defect
that is reasonably apparent upon physical inspection. During the applicable warranty period and no later than [****] from the discovery of any variances from the applicable specification that are not reasonably apparent on physical inspection,
Customer shall notify Supplier in writing of any such variances and each such notice shall also be treated as a “Non-Conformity Notice”; 

(v) If Supplier receives a Non-Conformity Notice from Customer, the Parties shall promptly work together to investigate whether the Products
in question are in compliance with the applicable specifications during the applicable warranty period. If Products are found to be non-compliant to the applicable specifications during the applicable warranty period, Supplier shall use commercially
reasonable efforts to replace or repair, at the Supplier’s discretion, all non-conforming Product for Customer in order to fulfill the requirement of the applicable Purchase Order. If the Products are found to comply with all relevant
specifications during the applicable warranty period, then Customer shall be deemed to have accepted the Products and shall pay for the same in accordance with this Agreement. 

(vi) In the event the Parties disagree on the outcome of these additional investigations related to disputed Products, the Parties shall
convene an immediate meeting of the Steering Committee, which will work in good faith to mutually and promptly resolve the disagreement. 

h. Exclusivity. 
 (i)
[****]. For the sake of clarity and the avoidance of doubt, [****]. For purposes of this Agreement, [****]. Supplier shall be the exclusive supplier to Customer and its affiliates of Products, [****] and Customer agrees that, except as expressly
permitted by Section 3.e in the case of Sustained Failure to Supply, it shall not satisfy any requirement for Products, [****] by its own manufacture or other self-supply. Customer agrees to use the Products solely with other Products.

 (ii) [****] to any [****] any [****] that [****] an [****] which has been [****] or any [****]. For clarity, [****] that [****] or a
[****]. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (iii) Notwithstanding anything to the contrary in this Agreement, [****] or otherwise [****] to
[****] for [****] and shall [****]. The [****] such that the [****] or [****]. For further clarity, the [****]. As consideration for [****]. 

i. Subcontracting. Supplier may subcontract, delegate or assign any part of its responsibilities under this Agreement to another party
with the consent of Customer which will not be unreasonably withheld or delayed. Customer acknowledges that Supplier currently subcontracts the manufacture of certain Instruments or Consumables, or components thereof. 

j. Sustained Failure to Supply. For purposes of this Agreement, a “Sustained Failure to Supply” means Supplier’s
failure to timely deliver at least [****], meeting the applicable specifications, required by a Binding Forecast submitted in accordance with this Agreement for a continuous period of [****], followed by Supplier’s failure to cure the same
within [****]. For clarity, [****], (i) [****] at the [****] or (ii) on [****]. 
 k. Additional Work Plan. The parties wish to
investigate means to enable Customer to integrate within its current products using the Instrument the additional capabilities [****]. To that end, the parties agree to use commercially reasonable efforts to jointly develop and agree upon a work
plan including high-level objectives, milestones and resourcing. 
 3. [****]; Sustained Failure to Supply 

a. [****]. Subject to the terms, conditions and limitations set forth in this Agreement, in order to [****] and [****] on the [****] for a
[****] to the [****].[****] on the [****] pursuant to [****] shall be [****] that the [****]as of [****] and the [****] following [****] the [****] of [****]. 

b. [****]. [****] necessary to [****]. 

(i) If, at any time [****] a [****] than the [****] in [****] an [****] so that [****]. However, before [****] will [****] that [****] that
[****] than the [****] shall [****] and either [****] or [****] to [****]. If [****] then [****]. In which case, [****] from [****].[****] of the [****] the [****] the [****] and [****] the [****] the [****] of the [****] for [****] with [****] each
time a [****] of the [****] and [****] and for which [****] in accordance with [****] is [****] for [****] the [****] by [****] even if [****] a [****] that [****]. Each [****] is also [****] for [****]. 

(ii) If, at any time [****] a[****] than the [****] in [****] an [****] so that [****]. However, before [****] that [****] that [****] than
the [****].[****] and either [****] or [****] to [****]; provided that [****] of the [****] with respect to the [****] for such [****] set forth in [****]. If [****] then [****]. In which case, [****] from [****].[****] of the [****] of the [****]
that [****] of an [****] and [****] the [****] of the [****] for [****] with [****] each time [****] and [****] and for which [****] the [****] in [****] with this [****] is [****] for [****] the [****] by this [****] even if [****] that [****] is
also [****]. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 c. [****]. Notwithstanding [****] and [****] of the [****] indicating that [****]. It is
understood and acknowledged that [****] and that therefore the [****]. [****] and [****] in accordance with [****] and to [****]. Notwithstanding the foregoing, from time to time, [****] and to [****] that the [****]. For clarity, [****] to the
extent that [****]. 
 d. [****]. If required [****] which shall [****] as defined in [****] and that [****] and thereafter, if [****]. 

e. [****]. In the event of [****]. In the case of [****]. 

f. [****]. In the event [****]. In the event [****] and notwithstanding anything herein to the contrary[****]. 

g. [****]. In no event and at no time [****] except in the case of [****] or in connection with [****] provided that [****]. Further, [****].

 h. [****]. Upon the [****] and if the [****] that were the [****]. If [****]. 

i. Access to Other Consumables. Upon written request from Customer, Supplier will use commercially reasonable efforts to certify
up to two (2) third parties under commercially reasonable terms to assist Customer in obtaining Other Consumables (such third parties, “Certified Third Party Suppliers”). The Certified Third Party Suppliers, if any, will be
permitted to so assist Customer solely in obtaining Other Consumables solely in the event that Supplier fails to supply to Customer Other Consumables because Supplier has dissolved. Supplier shall invoice Customer for Supplier’s overhead and
out-of-pocket costs associated with certifying such third parties and Customer shall promptly pay such invoices which shall not exceed [****] in total amount or such additional amounts as unanimously agreed to by the Steering Committee. For clarity,
Customer may not contact any Certified Third Party Supplier regarding this Agreement, or the Other Consumables, unless and until Supplier fails to supply to Customer Other Consumables because Supplier has dissolved.  

4. Confidentiality 
 a. Each party
and its affiliates, agents and representatives (each a “Recipient”) shall treat as confidential information of the other party or its affiliates (the “Discloser”) the information provided to the Recipient by the
Discloser hereunder or learned by the Recipient as a result of or in connection with this Agreement and/or that certain Mutual Confidentiality Agreement, dated as of January 27, 2011, and amended as of May 10, 2012, between the parties
hereof (“Confidential Information”). 
 b. The Recipient agrees to (i) hold in confidence all of Discloser’s
Confidential Information and not disclose such Confidential Information except as expressly permitted herein without the prior written consent of Discloser; (ii) use Discloser’s Confidential Information solely for the purpose of this
Agreement; (iii) treat Discloser’s Confidential Information with the same degree of care it uses to protect its own confidential information but in no event with less than a reasonable degree of care; and (iv) reproduce
Discloser’s Confidential Information solely to the extent necessary to accomplish the purposes of this Agreement, with all such reproductions being considered Discloser’s Confidential Information. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 c. Recipient may provide Discloser’s Confidential Information solely to its employees or
consultants on a need-to-know basis; provided, however, that (i) any such employees or consultants are bound by written obligations of confidentiality at least as restrictive as those set forth in this Agreement, and
(ii) Recipient remains liable for the compliance of such employees and consultants with such obligations. 
 d. Recipient will not have
obligations of non-disclosure and non-use with respect to any portion of Discloser’s Confidential Information which: 
 (i) is
generally known to the public at the time of disclosure or becomes generally known through no fault of Recipient; 
 (ii) is in the
Recipient’s possession at the time of disclosure other than as a result of Recipient’s breach of any legal obligation, as evidenced by Recipient’s written records; 

(iii) becomes known to Recipient through disclosure by sources other than Discloser having the legal right to disclose such Confidential
Information; or 
 (iv) is independently developed by Recipient without reference to or reliance upon the Discloser’s Confidential
Information, as evidenced by Recipient’s written records. 
 If Recipient is required by a governmental authority or by order of a court of competent
jurisdiction to disclose any of Discloser’s Confidential Information, Recipient will give Discloser prompt written notice thereof and Recipient shall take all reasonable and lawful actions to avoid or minimize the degree of such disclosure.
Recipient will reasonably cooperate with Discloser in any efforts to seek a protective order. 
 e. The obligations of each party under this
Section 4 shall remain in full force and effect for ten (10) years following termination or expiration of this Agreement. 
 5.
Intellectual Property 
 a. Proprietary Rights. Customer acknowledges that Supplier has spent considerable time and money
developing the technology in the Products, [****] (collectively, the “Systems Technology”) and, that as between the parties, Supplier is the exclusive owner of the Systems Technology. Under no circumstances will Customer modify,
attempt to reverse engineer any of such Systems Technology or use any such System Technology other than in compliance with the documentation provided by Supplier. However, Supplier may, at the request of Customer and on mutually agreeable terms,
modify any component of the Systems Technology solely for the purpose of facilitating or improving Customer’s internal operational use of the Systems Technology. Further, Supplier may authorize Customer to make such modifications, subject to
review and certification by Supplier. However, if Supplier elects to not implement a modification 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 
requested by Customer, or to authorize Customer to implement such modification, then Customer may nonetheless make the requested modification to any component of the System Technology
(hereafter an “Unapproved Modification”). Supplier shall have no obligation to extend any warranty terms or responsibility to service any Instrument if an Unapproved Modification causes the System Technology to not perform as
it otherwise would have without such Unapproved Modification. Any such modifications made in accordance with this Section 5.a shall be deemed “System Inventions”, as defined below. For clarity and without limiting the
foregoing, a decision by Supplier not to undertake such work or provide such authorization shall not constitute a breach of any obligation under this Agreement. Supplier shall have the sole and exclusive right but not the obligation to enforce all
rights with respect to the Systems Technology against third parties and Customer may only join in such activities when requested by Supplier.  

b. [****]. [****]. For the sake of clarity and the avoidance of doubt, [****] as may [****]. 

c. Inventions. All inventions, trade secrets, mask works, computer programs, (including source code and object code) algorithms,
products, processes, designs, ideas, discoveries, developments, and works of authorship, as well as improvements and innovations whether or not patentable, which are conceived, developed or reduced to practice by Customer alone or jointly with
others that pertain to the Systems Technology shall be the exclusive property of Supplier (“Systems Inventions”). Customer shall promptly notify Supplier of all Systems Inventions and [****]. Further, Customer shall execute such
instruments of transfers, applications and the like as Supplier may reasonably request to perfect its rights in the Systems Inventions. All Systems Inventions shall be considered Systems Technology for the purposes of this Agreement. [****].
However, notwithstanding the foregoing, [****]. 
 6. Additional Representations and Warranties 

a. Compliance. Each party shall comply with all applicable laws in performing its obligations hereunder. 

b. Authority. Each party represents and warrants that it: (i) is a corporation duly organized and validly existing and in good
standing under the laws of its jurisdiction of organization; (ii) is qualified or licensed to do business and in good standing in every jurisdiction where such qualification or licensing is required; and (iii) has the corporate power and
authority to negotiate, execute, deliver and perform its obligations under this Agreement. 
 c. No Conflict. Each party represents
and warrants that the execution and delivery of this Agreement by such party and the performance of such party’s obligations hereunder (i) do not conflict with or violate any requirement of applicable law existing as of the Effective Date
or the A&R Effective Date applicable to such party; and (ii) and does not conflict with, violate, breach or constitute a default under any contractual obligations of such party or any of its affiliates existing as of the Effective Date or
the A&R Effective Date. 
 d. Enforceability. Each party represents and warrants that as of the Effective Date and the A&R
Effective Date, this Agreement is a legal and binding obligation and is enforceable in accordance with its terms. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 e. Limited Applicability. The representations and warranties of a party set forth in this
Agreement are intended for the sole and exclusive benefit of the parties hereto, and may not be relied upon by any third party, other than permitted successors or assigns. 

f. Limitation. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH HEREIN, SUPPLIER MAKES NO REPRESENTATION NOR EXTENDS ANY WARRANTY OF ANY KIND,
EITHER EXPRESS OR IMPLIED, TO CUSTOMER, AND SUPPLIER HEREBY DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NONINFRINGEMENT WITH RESPECT TO THE PRODUCTS, [****], SERVICE CONTRACTS AND [****] SUPPLIED
HEREUNDER. 
 g. Product Representations and Warranties. Supplier represents and warrants to Customer, with respect to the Products,
[****]: 
 (i) Supplier has good title to all Products, [****]; 

(ii) there are no liens or encumbrances on or against any Products, [****]; 

(iii) Customer’s purchase and use of the Products, [****] as provided by Supplier, shall be free from any claim of infringement or
misappropriation of the intellectual property rights of a third party; provided that this representation and warranty does not apply to the extent that a claim is based on or arises from (A) alterations of the Products made by or behalf of
Customer, (B) improper use of the Products, or (C) use or combination of the Products with programs, data or devices not supplied by Supplier where use of the Products would be non-infringing without such use or combination of the Products
with such programs, data or devices not supplied by Supplier. 
 7. Disclaimer of Damages; Limitation of Liability 

NEITHER PARTY SHALL BE LIABLE FOR ANY SPECIAL, INDIRECT, INCIDENTAL, PUNITIVE OR CONSEQUENTIAL DAMAGES OF ANY KIND ARISING OUT OF OR RELATED TO THIS AGREEMENT,
HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY, WHETHER SUCH DAMAGES ARE BASED ON TORT, WARRANTY, CONTRACT OR ANY OTHER LEGAL THEORY, EVEN IF THE PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. 

8. Term and Termination 
 a.
Term. This Agreement shall have a term of five (5) years commencing on the Effective Date (the “Term”), which may be extended by written agreement of the parties. Additionally, the Parties may agree in writing to extend
the Term of this Agreement. 
 b. Termination for Cause. In addition to such other remedies as may be available to the non-breaching
party, either party may terminate this Agreement if the other party materially breaches any provision hereof and fails to cure such breach after written notice and a reasonable time and opportunity to effect such cure. For the sake of clarity and
the avoidance of doubt, a Sustained Failure to Supply shall not in itself constitute a material breach hereof and shall not give rise to Customer’s right to terminate for cause under this Section 8.b, and Customer’s sole remedy
therefor is set forth in Section 3.e. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 c. Termination without Cause. Customer may terminate this Agreement without cause on not
less than [****]; provided, however, that Customer pays Supplier in full for all Binding Forecasts placed prior to the effective date of termination. 

d. Effect of Termination. In the event of a termination or expiration of this Agreement in accordance with this Section 8,
all rights, privileges and obligations of the parties hereunder shall automatically terminate and, except as set forth by Section 8.e, neither party shall have any further rights or obligations except as may have accrued prior to the
expiration or termination. Within thirty (30) days following the expiration or termination of this Agreement, each party shall return to the other party, or upon the written request of the other party, destroy any and all Confidential
Information of the other party in its possession and upon a party’s request, such destruction (or delivery) shall be confirmed in writing to such party by a responsible officer of the other party. The obligations of the parties under this
subsection also shall apply on a product-by-product basis to the extent that this Agreement expires or is terminated with respect to a specific product only. Supplier shall not be obligated to buy back Products, [****] from Customer, or refund any
amounts paid for Service Contracts, in the event of any expiration or termination of this Agreement. 
 e. Survival. The provisions of
Sections 3 through 11 (inclusive) shall survive termination or expiration of this Agreement. 
 9. Indemnification 

a. Supplier Indemnification Obligations. Supplier shall defend, indemnify and hold Customer harmless from and against any third party
claim made against Customer which arises from or relates to Supplier’s breach of Section 6.g(iii). Supplier shall have no obligation of indemnity to the extent that any third party claim made against Customer arises from or relates
to (i) Customer’s breach of any material provision or Customer representation or warranty set forth in this Agreement; or (ii) Customer’s gross negligence or willful misconduct with respect to its obligations under this
Agreement. 
 b. Customer Indemnification Obligations. Customer shall defend, indemnify and hold Supplier harmless from and against
any third party claim of infringement or misappropriation of intellectual property rights of such third party made against Supplier which arises from or relates any specification of the Customer Library provided by Customer, Unapproved
Modifications, and modifications made to the Systems Technology at Customer’s request. Customer shall have no obligation of indemnity to the extent that any third party claim made against Supplier arises from or relates to
(i) Supplier’s breach of any material provision or Supplier’s representation or warranty set forth in this Agreement; or (ii) Supplier’s gross negligence or willful misconduct with respect to its obligations under this
Agreement. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 10. Steering Committee 

a. Steering Committee. The parties shall establish and maintain a steering committee (the “Steering Committee”) and the
following shall apply: 
 (i) the Steering Committee shall comprise four individuals in total. Each of the parties shall appoint, and may
from time to time remove, and reappoint two members of the Steering Committee; 
 (ii) the role of the Steering Committee shall be to manage
the relationship between the parties in all respects, to oversee the conduct of this Agreement, to resolve differences and difficulties which may arise in the course of the Agreement, to review each party’s performance under this Agreement, and
to discuss any issues that arise regarding performance under this Agreement; 
 (iii) the Steering Committee may consider projects on behalf
of each party and related terms and conditions, including compensation; provided that a decision by either party not to undertake such projects shall not constitute a breach of any obligation under this Agreement; 

(iv) the Steering Committee shall meet on a quarterly basis, in person or via teleconference, and otherwise as considered appropriate; 

(v) each party shall appoint a leader of its Steering Committee team whose responsibility shall be to initiate and maintain contact with
Steering Committee team leader of the other party; and 
 (vi) the Steering Committee shall not have power to vary this Agreement or to bind
either of the parties to any legal commitment. 
 b. Information Exchange. Each of the parties shall keep the other informed about
matters within its knowledge that are likely to have a material effect upon the operation of this Agreement and in particular Supplier shall report to Customer on a quarterly basis the shipments and delivery lead times for Products delivered during
the quarter under report. In the event a material quality issue is identified by either party that is likely to have a material adverse effect on the delivery of products, the parties shall then consult together as a matter of urgency to agree to
the validity of the problem and agree to a solution to the problem, both in respect of maintaining deliveries and in respect of resolving the production problem. 

c. Dispute Resolution. The parties each recognize that it is important to establish a close working relationship, to avoid disputes
arising and to ensure that any disputes which do are speedily resolved without interruption to the operation of this Agreement or the commercial relationship between them. Accordingly, if any dispute arises under or in relation to this Agreement:

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 (i) the parties shall seek in good faith to resolve the same as soon as practicable so as not to
interfere with or damage the working relationship between them; 
 (ii) the existence of any dispute shall not be treated as a reason for
withholding purchase orders, supplies, payment or other performance of this Agreement other than payment of amounts which are disputed in good faith as provided herein; 

(iii) if either party considers that the other is in breach of its obligations under this Agreement and wishes to take action in respect of
such breach it shall notify the other party of the breach with relevant information in its possession concerning the breach and a summary of its proposals in respect of it. The parties shall then consult in good faith with regard to actions to be
taken to cure the breach and prevent a repetition and if the party in breach puts forward reasonable proposals in that respect (taking into account any previous similar breach) within thirty (30) days of the notice of breach, the party
complaining of the breach shall allow a reasonable period (being not less than fifteen days nor more than forty-five days) for the same to be implemented; 

(iv) any dispute or difference shall be referred in the first instance to the Steering Committee which shall diligently seek to resolve the
same. If the Steering Committee fails to resolve the same, the relationship team members of each party shall prepare a written memorandum summarizing the matter in dispute, their views upon it and their understanding of the other party’s views
upon it and the parties shall then exchange their respective memoranda and the Steering Committee shall then meet again to discuss the matter. If at that meeting they fail to resolve the matter the memoranda prepared by the parties and discussed at
the meeting, together with minutes of the meeting, shall be submitted to the President of each party, who shall meet as soon as practicable and seek to resolve the matter. All such activities contemplated in this Section 10.c(iv) to be
completed within thirty (30) days of the notice of breach provided for under Section 10.c(iii); 
 (v) subject to
Section 10.c(vi), a party shall not: (A) serve any notice under Section 8.b by reason of a breach by the other party of its obligations under this Agreement (but shall remain entitled to any compensation available to it
in law) and any such notice purportedly given in respect of that breach shall be of no effect; nor (B) commence any legal proceedings in respect of the breach or matter in dispute unless in either case it has allowed any implementation period
required by Section 10.c(iii) to expire and the remedy has been unsuccessful, has caused its members of the Steering Committee to be reasonably available to meet those of the other party, has submitted to the other party the memorandum
required by Section 10.c(iv) and has made its President reasonably available to meet pursuant to Section 10.c(iv); and 

(vi) subject to any binding agreement resolving a dispute and subject to the foregoing, nothing in this Section 10 shall prevent
or restrict any party from exercising its rights and remedies in law and notwithstanding the foregoing either party may apply to court for injunctive relief in respect of any breach or alleged breach of any material provision of this Agreement or
for a court order for payment of any invoice that is overdue for payment. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 11. General 

a. Notices. All notices in connection with this Agreement shall be addressed to the President of the receiving party at the applicable
address set forth above (or to such other address as the party to receive the notice so designates by written notice to the other) and shall be deemed given on the business day following the date they are sent by over-night courier, charges prepaid.
Notwithstanding the foregoing, Customer hereby acknowledges that as of June 1, 2013, Supplier’s address shall be 749 Middlesex Turnpike, Billerica, MA 01821. 

b. Entire Agreement. This Agreement contains the entire agreement of the parties with respect to the subject matter hereof, and
supersedes and merges all prior and contemporaneous communications, including, but not limited to, the Supply Agreement and Amendment 1. This Agreement may not be amended except by a written agreement signed by the parties. Either party may use its
standard business forms (such as purchase orders) in connection with this Agreement, but use of such forms shall be for convenience purposes only, and any provision therein that conflicts with a provision of this Agreement shall be deemed stricken
and null and void, unless the parties agree otherwise in a signed written agreement that specifically refers to this Agreement. 
 c.
Governing Law. This Agreement shall be construed and controlled by the laws of the Commonwealth of Massachusetts, without regard to its conflict of laws principles. 

d. Damages. In any dispute hereunder, each party shall be responsible for its own fees, costs, and other expenses. 

e. Waiver. No waiver of any breach of any provision of this Agreement shall constitute a waiver of any prior, concurrent or subsequent
breach of the same or any other provision hereof, and no waiver shall be effective unless made in writing and signed by an authorized representative of the waiving party. 

f. Relationship. The relationship between Supplier and Customer is solely that of independent contractors. Neither this Agreement, nor
any terms and conditions contained herein, shall be construed as creating a partnership, joint venture or agency relationship or as granting a franchise. Neither party shall have the authority to represent or bind the other. 

g. Assignment. Neither party may assign this Agreement, or any of its rights or obligations hereunder, without the written consent of
the other party, which consent shall not be unreasonably withheld; provided, however, either party may transfer or assign this Agreement, in whole or in part, without the prior written consent of the other party, to one of its affiliates or in
connection with a merger, consolidation, or a sale or transfer of all or substantially all of the assets to which this Agreement relates. 

h. Force Majeure. Neither party shall be held responsible for any delay or failure in performance of its obligations hereunder to the
extent such delay or failure is caused by fire, flood, strike, civil, governmental or military authority, act of God, or other similar causes beyond its reasonable control and without the fault or negligence of the delayed or non-performing party or
its subcontractors. 
 i. Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed to
be an original and all of which together shall constitute one and the same instrument. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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 IN WITNESS WHEREOF, the parties have executed this First Amended and Restated Supply Agreement
under seal as of the A&R Effective Date. 
  
  

									
	RAINDANCE TECHNOLOGIES, INC.	  		  	MYRIAD GENETIC LABORATORIES, INC.
					
	By:	  	 /s/ S. Roopom Banerjee
	  		  	By:	  	 /s/ Mark Capone

	Name: S. Roopom Banerjee	  		  	Name: Mark Capone
	Title: President and CEO	  		  	Title: President

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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 Exhibit A 

RDT ThunderStormTM Instrument 

Instrument General Description and Functionality 
  

	 	•	 	The Instrument is designed to accommodate 250 ng to 1.5 micrograms of genomic DNA (that has been prepared according to RDT-recommended protocols). 

 

	 	•	 	The Instrument enables the formation of up to 1,000,000 individual PCR reactions of 26 picoliters per reaction using 25 microliter input sample volume, [****]. 

 

	 	•	 	Disposable single-use chips and sample loading and collection devices are employed to address sample carryover or cross-contamination. 

Instrument Features 
  

	 	•	 	Bench-top size (w 41.2 in., d ~ 30 in., h ~ 29.2 in., weight <450 lb.). 

  

	 	•	 	Power source 100/240 VAC, 50/60 Hz. 

  

	 	•	 	Ability to process up to 96 samples per run. 

  

	 	•	 	Ability to maintain up to 8 library vials on the Instrument for [****]. 

  

	 	•	 	Ability to map samples against any installed library. 

  

	 	•	 	Unattended/walk away operation by users. 

  

	 	•	 	96 well sample input and output positions. 

  

	 	•	 	Temperature control of input and output sample positions and library vials (10°C) 

  

	 	•	 	Integrated barcode scanner for recording details of reagents and samples processed on the Instrument. 

  

	 	•	 	Error detection system supports user warning and minimizes sample and reagent waste. 

  

	 	•	 	Remote assist software for technical support, troubleshooting and diagnostics in consultation with Supplier service and support personnel. 

 

	 	•	 	Integrated reagent reservoirs with sensor systems to detect and prompt user to replace at appropriate intervals. 

  

	 	•	 	Safety and Compliance: 

  

	 	•	 	IEC 61010-1; 2001 (UL/CSA/CENELEC/EN) 

  

	 	•	 	FCC compliant Class B device 

  

	 	•	 	TUV listed 

  

	 	•	 	CE marked 

 Instrument Specifications: 

Installation Qualification (“IQ”): 
  

	 	•	 	Operating Conditions: 

  

	 	•	 	Laboratory Ambient Temperature:15-30oC 

  

	 	•	 	Ambient Temperature Fluctuation: Not to exceed +/- 5oC per hour 

  

	 	•	 	Relative Humidity: 5-85% RH, non-condensing 

  

	 	•	 	Atmospheric Pressure: 800-1600mbar 

 Operational Qualification (“OQ”): 

 

	 	•	 	Volume dispensed: 

  

	 	•	 	[****] 

  

	 	•	 	Successful Completion of System Acceptance Test (as defined below) 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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	 	•	 	All safety devices checked and operate as designed, appropriate signage posted 

 System Acceptance Test
for Instruments (SAT) 
 The following test shall be performed by Supplier following delivery and installation of any new Instrument at
Customer’s facility in Salt Lake City, Utah. Successful completion of this SAT shall be verification that the Instrument has been installed and meets the Instrument Specifications. Subsequent issues encountered with an Instrument’s
compliance to the Specifications shall be addressed by Supplier’s obligations under the Service Contracts. 
 SAT Protocol: 

[****] 
 Performance
Qualification (“PQ”): 
  

	 	•	 	Sample success rate (as determined by merge quality of [****] and emulsion dispensed into reaction plate) [****] with Customer Library 

 

	 	•	 	Exceptions: Failures caused by sample input or other failures attributable to Customer (including, but not limited to, failure to satisfy the Customer Qualifications) 

 

	 	•	 	Run completion rate (completing all samples desired without interruption or requiring user intervention): [****] 

  

	 	•	 	[****] 

  

	 	•	 	Exceptions: Failures caused by sample input or other failures attributable to Customer (including, but not limited to, failure to satisfy the Customer Qualifications) 

 

	 	•	 	Exceptions: 

  

	 	•	 	[****] 

  

	 	•	 	Use of pipette tips that are outside specifications 

  

	 	•	 	Time to run completion: 

  

	 	•	 	[****] 

  

	 	•	 	System Up-Time: Average [****] 

  

	 	•	 	Defined as Instrument in operational order [****]. 

 PQ will be verified during the first 3
months following Instrument System IQ and OQ procedures (the “PQ Verification Period”). In the event the PQ conditions are not being met during the PQ Verification Period, Customer shall inform Supplier promptly, at which point Supplier
shall employ commercially reasonable efforts to remedy the situation. In the event the System continues to not meet the PQ criterion during the PQ Verification Period, the Parties shall negotiate in good faith to resolve the situation, up to and
including, the potential replacement of the Instrument. 
  

	 	•	 	[****] Lead-time for Instruments is [****]. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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 Exhibit B 

Consumables 
 Lot Size: Lot
size of Customer Libraries shall be based upon the size of the oligonucleotide synthesis. Oligonucleotides will be synthesized [****] or less frequently, as determined by Supplier. Supplier will use the same lot of oils throughout the
dropletization process of each lot of Customer Libraries. 
 Other Consumables Specifications 

 

	 	•	 	Instrument Consumable Kit (48-pack Part Number 20-03551 Rev. B-01) consists of the following components: 

  

	 	•	 	Thunderstorm Chip Stack (RDT P/N 30-04265) 

  

	 	•	 	24 chips per package 

  

	 	•	 	Storage Conditions: Ambient 

  

	 	•	 	RainDance Stabilizer/Destabilizer Kit (RDT P/N 20-00803) 

  

	 	•	 	Droplet Stabilizer 

  

	 	•	 	Droplet Destabilizer 

  

	 	•	 	Stability: [****] 

  

	 	•	 	Storage Conditions: 4oC-35oC 

 

	 	•	 	RainDance Oil Kit (RDT P/N 20-02119) 

  

	 	•	 	Carrier Oil 

  

	 	•	 	Template Drive Oil 

  

	 	•	 	Stability: [****] 

  

	 	•	 	Storage Conditions: 4oC-35oC 

Customer Library: Features 
 The Customer
Library is an emulsified mixture of Customer-defined oligonucleotides, which is provided to the Customer in vials to be installed and used solely on the Instrument. The DNA sequences to create the Customer Library are provided to Supplier by the
Customer. The specific components desired are defined by the Supplier, in the form of an electronic spreadsheet (the “Master Library File”). 

Once the Customer has reviewed and approved in writing the Master Library File, Supplier shall use this Master Library File as the basis for
work instructions to manufacture, or have manufactured, the Customer Library. 
 Any changes, adjustments or alterations to the design
features or components of the Customer Library, as designated in the Master Library File, shall be mutually agreed to in writing between the Parties. The parties shall also agree upon the manner by which such changes are effectively documented and
archived. 
 Customer Library: Specifications 
  

	 	•	 	Available in configurations sufficient to support either 8 or 48 samples. 

  

	 	•	 	Available in configurations to support [****]. 

  

	 	•	 	Customer Library may be designed and provided as singleplex (two paired oligonucleotide primers per droplet) or multiplex (more than two paired oligonucleotide primers per droplet) configurations. 

 

	 	•	 	Customer Library Shelf life as warranted in Section 1.b(ii). 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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	 	•	 	Customer Library shall have a working stability of [****]. The Instrument has been programmed to prohibit use of a Customer Library that exceeds this stability dating. 

Customer Library: Manufacturing Process Specifications 
  

	 	•	 	Mean Droplet Size: [****] 

  

	 	•	 	R2: [****] 

  

	 	•	 	%CV: [****] 

 Customer Library: Functional Performance Specifications 

 

	 	•	 	[****] 

 [****] lead time for Customer Library is as follows: 

 

	 	•	 	[****] 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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 Exhibit C 

Description and specifications of [****] 

[****] 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
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 Exhibit D 

Instrument and Consumables Pricing 

Instrument pricing: [****] 
 Consumables and Customer
Library Pricing for Consumables and Customer Library Forecasted and Ordered [****]: 
  

	 	•	 	Price-volume curve (based upon current Customer Library design [****] Reference Master Library  

  

	 	•	 	NOTE: The parties acknowledge that as of the Effective Date, [****]. 

  

					
	 Sample Order per 6 months
	  	 Price per Sample*
	  	 
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	
	[****]	  	[****]	  	

  

	*	Price per Sample is determined by the design and components of the Customer Library, as indicated by the Master Library File. Any changes to the design that are requested by the Customer may require an adjustment to the
Price per Sample. 

 Consumables and Customer Library Pricing for Consumables and Customer Library Forecasted and Ordered [****]:[****]
per sample. 
  

	 	•	 	Customer may request that Supplier sell to Customer certain products that are not addressed by this Agreement. If Supplier agrees to sell such products to Customer, Supplier and Customer shall negotiate in
good-faith the price for such products. 

 Products included in support of the Price per Sample: 

 

	 	•	 	Instrument Consumable Kit 

  

	 	•	 	Customer Library 

 Customer Library Pricing for Customer Library Forecasted and Ordered [****]:[****]
per sample. 
 Additional Services 

Customer shall pay for oligonucleotide primer library synthesis at standard list prices. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 Taxes 

All prices are exclusive of value added tax and sales tax and any similar tax, all of which Customer shall pay in addition to the prices set
forth herein. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 Exhibit E 

Service Contracts and Pricing 

Annual Fee for each Service Contract: [****] per Instrument installed at Customer’s location 

Supplier’s obligations under Service Contracts: 

Provide unlimited remote and on-site support for all hardware, software and application failures. Includes: replacement parts, software
revisions, replacement Consumables due to Instrument-related failures, and at least one scheduled preventative maintenance visit per Instrument per year. 

Excludes: Customer responsible items. 

Response times: Supplier shall remotely respond to service calls within [****]. Such response will include an assessment of the issue and
consideration of whether on-site service is required. In the event that such service is required, a service engineer will be on site [****]. Customer acknowledges that many issues can and will be resolved by Supplier remotely and Customer will
facilitate Supplier’s on-line access to the relevant Instrument for diagnosis and repair purposes. 
 System Recertification Test (SRT) 

The following test shall be performed by Supplier following a repair to an Instrument performed by the Supplier’s Service and Support
personnel that at Supplier’s discretion, is of a significant nature and requires confirmation that the Instrument has been repaired in a manner to confirm it is performing according to the applicable Specifications. Successful completion of
this SRT shall be verification that the Instrument has been repaired sufficiently to meet the Instrument Specifications. 
 Initiate an
Instrument run of [****] – load chips, take off/put back on tips, load appropriate test libraries. Perform run. Run is to complete without interruption. [****], and visual check errors such as a dispense output plate will be visually inspected
to confirm no more than [****]. 
 Customer Training: 

Supplier shall provide training to Customer personnel on the use of the Instrument. Such training shall be made available so that all intended
users of the Instrument become proficient in the proper use of the Instrument, as will be demonstrated by the successful completion of a user certification process. 
  

	 	•	 	Whenever practically possible, training will be coordinated so that multiple personnel will be trained at the same time. 

  

	 	•	 	Training obligations and additional fees associated with training at Customer locations other than Customer’s Salt Lake City, Utah location shall be determined between the Parties in advance. 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 Exhibit F 

Initial Forecast 
  

			
	 Month
	  	 Consumables to Process the

following number of Samples

		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]
		
	 [****]
	  	[****]

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 Exhibit G 

[****] 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 AMENDMENT 1 TO AMENDED AND RESTATED SUPPLY AGREEMENT 

This Amendment 1 to First Amended and Restated Supply Agreement (this “A&R Amendment 1”) is entered into as of February
24, 2015 (the “A&R Amendment 1 Effective Date”) by and between RainDance Technologies, Inc., a Delaware corporation, with principal offices at 749 Middlesex Turnpike, Billerica, MA 01821 (“Supplier”) and Myriad
Genetic Laboratories Inc., a Delaware corporation, with principal offices at 320 Wakara Way, Salt Lake City, Utah 84108 (“Customer”). 

WHEREAS, Supplier and Customer entered into the First Amended and Restated Supply Agreement, dated June 25, 2014 (the “A&R Supply
Agreement”), pursuant to which Customer purchases Instruments, Customer Libraries, Other Consumables [****]; and 
 WHEREAS,
Supplier and Customer desire to amend the A&R Supply Agreement on the terms and conditions set forth herein. 
 NOW THEREFORE, in
consideration of the mutual promises herein set forth and other good and valuable consideration, the parties agree as follows: 
 1. Defined Terms.
Defined terms used and not defined herein shall have the meanings ascribed to them in the A&R Supply Agreement. 
 2. Amendments. 

 

	 	a.	The warranty period in Section l.b.ii.A is changed from “[****]” to [****]. 

  

	 	b.	The following text is hereby deleted from Section l.b.(ii) of the A&R Supply Agreement: 

“The parties will use commercially reasonable efforts to [****], and will in good faith correspondingly modify the applicable Library
Specifications and the warranty period under Section l.b.(ii)(A). Also, the parties will in good faith establish the Functional Performance Specifications of the Library Specifications [****] of first delivery of Customer Library to
Customer.” 
  

	 	c.	The word “quarterly” is hereby deleted from Section 10.a.(iv) of the A&R Supply Agreement and replaced with “semi-annual”. 

 

	 	d.	The “System Acceptance Test for Instruments (SAT)” Section (but not the “Performance Qualification (“PQ”)” Section of Exhibit A or anything that follows such “Performance Qualification
(“PQ”)” Section) is hereby deleted from Exhibit A to the A&R Supply Agreement and replaced with the following: 

“System Acceptance Test for Instruments (SAT) 
  

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 The test described in Exhibit A--1 attached hereto shall be performed by Supplier following
delivery and installation of any new Instrument at Customer’s facility in Sail Lake City, Utah. Successful completion of this SAT shall be verification that the Instrument has been installed and meets the Instrument Specifications. Subsequent
issues encountered with an Instrument’s compliance to the Specifications shall be addressed by Supplier’s obligations under the Service Contracts, 

[****] 
  

	 	e.	Exhibit A-l attached to this A&R Amendment 1 is hereby added to the A&R Supply Agreement as Exhibit A-1 thereto, 

3. General. 
  

	 	a.	Except as expressly set forth in this A&R Amendment 1, the A&R Supply Agreement is unaffected and shall continue in full force and effect in accordance with its terms. This A&R Amendment 1 amends and is
hereby made a part of the A&R Supply Agreement. If there is conflict between this A&R Amendment 1 and the A&R Supply Agreement, the terms of this A&R Amendment I will prevail. 

 

	 	b.	This A&R Amendment 1 may be executed in two or more counterparts, each of which shall be deemed to be an original and all of which together shall constitute one and the same instrument. Facsimile or pdf image
signatures shall be treated as original signatures. 

 IN WITNESS WHEREOF, (he parties have executed this A&R Amendment 1
under seal as of the A&R Amendment 1 Effective Date. 
  

									
	RAINDANCE TECHNOLOGIES, INC,				MYRIAD GENETIC LABORATORIES, INC.
					
	By:		 /s/ S. Roopom Banerjee
		  		By:		 /s/ Jeff Trost

	Name:		S. Roopom Banerjee				Name:		Jeff Trost
	Title:		President and CEO				Title:		Sr. VP Operations

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.

 Exhibit A-1 

[****] 

  
 CONFIDENTIAL TREATMENT REQUESTED UNDER
C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE COMMISSION.EX-10.16

 Exhibit 10.16 

SUPPLY AGREEMENT 
 THIS AGREEMENT
is made as of the 24th day of February, 2009, by and between Sigma-Aldrich Inc., having an office at 3050 Spruce Street, St. Louis, MO 63103 (“SIGMA”), and Rain Dance Technologies, Inc., having an office at 44 Hartwell Avenue, Lexington,
MA 02421 (“BUYER”). 
 WHEREAS, SIGMA has the experience and capability to supply primers and /or design service as further
described in Exhibit A, and 
 WHEREAS, Buyer desires to have available on a coordinated continuing basis a supply of said product, 

NOW, THEREFORE, in consideration of the premises and mutual covenants and conditions contained herein, the parties hereto agree as follows:

 ARTICLE I 
 DEFINITIONS

 For the purposes of this Agreement, the following words and phrases shall have the following meanings: 

 

	 	1.1	“Effective Date” shall mean 2-24-09. 

  

	 	1.2	“Government Approvals” shall mean any approvals, licenses, permits, registrations or authorizations, howsoever called, of any United States or foreign regulatory agency, department, bureau or other government
entity necessary for SIGMA’s manufacture, use, storage, transport or sale of the Product. 

  

	 	1.3	“Product” shall mean Primers and/or their Design as described in Exhibit A attached hereto. 

  

	 	1.4	“Specifications” shall mean the specifications for the Product set out in Exhibit A attached hereto, as shall be amended from time to time by mutual written agreement of the parties. 

 

	 	1.5	“Term” shall mean from 2-24-09 to 2-23-12 unless extended as provided for herein. 

ARTICLE II 
 SUPPLY 

 

	 	2.1	 Requests for design will be placed as described in Exhibit B, and orders for Oligonucleotide synthesis will be placed by Buyer according to process
described in Exhibit B. All terms and conditions of this Agreement shall supersede any terms or conditions of said Purchase Order, which modify or are otherwise 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	
inconsistent with the terms and conditions of this Agreement, unless other terms and conditions are signed by both Parties. All Products will be supplied by SIGMA in accordance with the
Specifications in Exhibit A. 

  

	 	2.2	All Product supplied by SIGMA shall be supplied F.O.B. The Woodlands, Texas. 

  

	 	2.3	SIGMA shall ship Products in a commercially reasonable manner in accordance with Buyer’s reasonable instructions. 

  

	 	2.4	SIGMA shall accept and adhere to the requirements of the Vendor Quality Agreement set out in Exhibit D. 

  

	 	2.5	In the event that any portion of the shipment of Products received by Buyer fails to conform to the Specifications, Buyer may reject the non-conforming Products shipment by giving written notice to SIGMA within thirty
(30) days of Buyer’s receipt of the Products, which notice shall specify the manner in which the Products fail to meet the Specifications. In the event a Product defect could not have been ascertained by Buyer upon reasonable inspection of
the Product and analysis thereof, then the thirty (30) day time period referred to herein shall not apply provided that (i) Buyer notifies SIGMA promptly upon having reason to know of such Product defect (but in any event no later than
three (3) months from date of delivery) and (ii) the limitation on remedy and liability set out in Section 2.7 shall apply with respect thereto. 

  

	 	2.6	In the event SIGMA does not agree that any such Product failed to meet the Specifications (per Section 2.1) and SIGMA and Buyer cannot reach agreement with respect to such Product, SIGMA will submit the question of
whether the Product failed to meet the Specifications to an independent laboratory selected by SIGMA and approved by Buyer for determination. The findings of such laboratory shall be binding upon SIGMA and Buyer and the cost of such determination
shall be paid by the party in error. 

  

	 	2.7	Subject to Sections 2.4 and 2.5, SIGMA shall replace any Product not conforming to the Specifications forthwith at its expense within 15 business days of receiving Buyer’s written notice of non-conformity. Buyer
shall return, at SIGMA’s expense, the nonaccepted Products to SIGMA. 

  

	 	2.8	Except as provided for under Section 4.5 regarding SIGMA’s indemnification obligations for third party claims, the remedies described in Section 2.5 and 2.6 shall be Buyer’s sole remedy and
SIGMA’s only liability to Buyer hereunder with respect thereto. 

  

	 	2.9	SIGMA warrants that all federal environmental and safety requirements are being and will be followed at its facilities. Buyer shall have the right to inspect at reasonable times during normal business hours, and on
reasonable prior notice, the operations and facilities of SIGMA wherein Products are manufactured to evaluate compliance with applicable environmental and occupational health and safety laws and regulations. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	2.10	SIGMA shall notify Buyer of significant incidents relating to production of the Product, including but not limited to the following (i) fatalities and/or significant injuries or occupations illnesses;
(ii) incidents resulting in property damage of [****] or more; (iii) environmental releases reportable to regulatory agencies; (iv) regulatory agency inspections alleging non-compliance; and (v) request for information, notices
of violations or other communication from a governmental agency relating to environmental or occupational health and safety compliance. 

  

	 	2.11	At Buyer’s request, SIGMA shall provide copies of all relevant environmental licenses and permits pertaining to its operation and shall notify Buyer of any change in status. 

 

	 	2.12	At Buyer’s request, SIGMA will provide Buyer with copies of all applicable insurance certificates. 

  

	 	2.13	SIGMA agrees that it will conduct all necessary testing of Product as required by any and all applicable governmental regulations. 

ARTICLE III 

PRICING & FORECASTING 
  

	 	3.1	Subject to Section 3.2, the purchase price to be paid by Buyer for the Product during the Term of this Agreement shall be set forth in Exhibit C. 

 

	 	3.2	In preparation for Year 2 of this Agreement, the Buyer shall provide a purchase forecast for the next year to SIGMA at least 60 days prior to the end of the current year. 

 

	 	3.3	Following the first (1) year of this Agreement, the pricing in Exhibit C is subject to adjustment annually, based on the number of primers ordered per year. SIGMA shall provide a price quotation to BUYER at least
30 days prior to any annual adjustment. 

  

	 	3.4	The price can be [****] after [****] of the Effective Date if [****] or, [****]. SIGMA will provide documentation as to the [****] and [****]. 

 

	 	3.5	Buyer shall [****]. 

  

	 	3.6	Should Buyer elect to extend the Agreement an additional [****] as provided for in Section 7.1, the price shall be reviewed [****] for the additional [****]. 

 

	 	3.7	Buyer shall make payments to SIGMA for the purchase price of Product within forty five (45) days after delivery thereof. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 ARTICLE IV 

REPRESENTATIONS AND WARRANTIES 
  

	 	4.1	Each party represents and warrants to the other that the execution of this Agreement and the full performance and enjoyment of the rights of SIGMA and Buyer under this Agreement will not breach or in any way be
inconsistent with the terms and conditions of any license, contract, understanding or agreement, whether express, implied, written or oral between the warranting party and any third party. 

 

	 	4.2	Buyer represents and warrants that, to the best of its knowledge as of the date of this Agreement, no patents, patent applications if issued, or any other proprietary rights of any third party would be infringed by the
manufacture, use or sale of the Product. 

  

	 	4.3	SIGMA warrants that all Products supplied by SIGMA pursuant to Section 2.1 shall be free from defects in materials and workmanship, shall be of merchantable quality, shall conform to the requirement of applicable
federal and state regulatory requirements, shall have all necessary Government Approvals and shall meet the Specifications. At BUYER’S request, SIGMA shall certify in writing that it is in substantial compliance with all applicable
environmental and occupational health and safety laws and regulations. 

  

	 	4.4	SIGMA DISCLAIMS ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING, WITHOUT LIMITATION, ANY IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR ANY PARTICULAR PURPOSE OR AGAINST ANY INFRINGEMENT OF PRODUCTS OR
OTHERWISE. SIGMA-ALDRICH SHALL NOT IN ANY EVENT BE LIABLE FOR INCIDENTAL, CONSEQUENTIAL OR SPECIAL DAMAGES OF ANY KIND RESULTING FROM ANY USE OR FAILURE OF THE PRODUCTS, EVEN IF SIGMA-ALDRICH HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGE
INCLUDING, WITHOUT LIMITATION, LIABILITY FOR LOSS OF USE, LOSS OF WORK IN PROGRESS, DOWN TIME, LOSS OF REVENUE OR PROFITS, FAILURE TO REALIZE SAVINGS, LOSS OF PRODUCTS OF COMPANY OR ITS CUSTOMER OR OTHER USE OR ANY LIABILITY OF COMPANY OR ITS
CUSTOMER TO A THIRD PARTY ON ACCOUNT OF SUCH LOSS, OR FOR ANY LABOR OR ANY OTHER EXPENSE, DAMAGE OR LOSS OCCASIONED BY SUCH PRODUCT INCLUDING PERSONAL INJURY OR PROPERTY DAMAGE UNLESS SUCH PERSONAL INJURY OR PROPERTY DAMAGE IS CAUSED BY
SIGMA-ALDRICH’S GROSS NEGLIGENCE. All claims must be brought within [****], regardless of their nature. 

  

	 	4.5	 Subject to Section 4.6, SIGMA shall indemnify, defend and hold harmless Buyer from all actions, losses, claims, demands, damages, costs and
liabilities (including reasonable attorneys’ fees) to which BUYER is or may become subject insofar as 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	
they arise out of or are alleged or claimed to arise out of (i), any breach by SIGMA of any of its obligations under this Agreement or warranties of SIGMA, or (ii) any negligent or willful
act or omission by SIGMA or its employee, agents or subcontractors or (iii) personal injury, death or property damage sustained by any person(s) resulting from any SIGMA service or the use or handling of any SIGMA product. 

 

	 	4.6	Subject to Section 4.5, BUYER shall indemnify, defend and hold harmless SIGMA from all actions, losses, claims, demands, costs and liabilities (including reasonable attorney’s fees) to which SIGMA is or may
become subject insofar as they arise out of or are alleged or claimed to arise out of (i) any breach by BUYER of any of its obligations under this Agreement, (ii) any negligent or willful act or omission by BUYER or its employees, agents
or subcontractors, (iii) personal injury, death or property damage sustained by any person(s) resulting from the use of Product manufactured by BUYER or by a third party at the direction of BUYER, or (iv) any labeling, advertising or
promotional materials used by BUYER. 

  

	 	4.7	A party entitled to indemnification hereunder agrees to give prompt written notice to the indemnifying party after the receipt by such party of any written notice of the commencement of any action, suit, proceeding or
investigation or threat thereof made in writing for which such party will claim indemnification pursuant to this Agreement and cooperate fully with the indemnifying party in conducting such defense. Unless, in the reasonable judgment of the
indemnified party, a conflict of interest may exist between the indemnified party and the indemnifying party with respect to a claim, the indemnifying party may assume the defense of such claim with counsel reasonably satisfactory to the indemnified
party. If the indemnifying party is not entitled to, or elects not to, assume the defense of a claim, it will not be obligated to pay the fees and expenses of more than one counsel with respect to such claim. The indemnifying party will not be
subject to any liability for any settlement made without its consent, which shall not be unreasonably withheld. 

  

	 	4.8	The provisions and obligations of this Article IV shall survive any termination of this Agreement. 

ARTICLE V 
 RECALLS AND RETURNS

  

	 	5.1	 In the event of a recall involving any BUYER finished product containing Product supplied hereunder is required by a governmental agency or authority
of competent jurisdiction or if recall is deemed advisable by BUYER, such recall shall be promptly implemented and administered by BUYER in a manner which is appropriate and reasonable under the circumstances and conformity with accepted trade
practices. Subject to Section 5.2, in the event that a recall is required as a result of BUYER’S breach of its obligations hereunder, all costs and 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	
expenses incurred in connection therewith will be borne by BUYER. Subject to Section 5.2, in the event that a recall is required as a result of SIGMA’s breach of its obligations
hereunder, all costs and expenses incurred in connection therewith shall be borne by SIGMA. 

  

	 	5.2	Notwithstanding anything in this Agreement to the contrary, in the event of any recall, neither party shall be liable to the other party for special, incidental or consequential damages, loss of profit or loss of use,
whether a claim arises in tort or contract. The limitation on liability provided for herein shall apply even in the event of the fault, negligence or strict liability of the party that may be responsible for the liability associated with such recall
or the Products recalled. 

  

	 	5.3	The provisions and obligations of this Article V shall survive any termination of this Agreement. 

ARTICLE VI 
 CONFIDENTIALITY

  

	 	6.1	During the term of this Agreement each party may disclose information to the other party that is of a confidential or proprietary nature. Information which is designated in writing to be confidential or, if disclosed
orally, reduced to writing and designated as confidential within thirty (30) days of such disclosure (Confidential Information) shall be maintained in confidence by the receiving party and not disclosed to third parties except upon the
disclosing party’s prior written consent. It shall be understood, however, that Confidential Information shall not include, and the obligations of confidentiality and nondisclosure shall not apply to, disclosed information that:

  

	 	a)	is or becomes publicly available through no fault of the receiving party; 

  

	 	b)	is disclosed without restriction to the receiving party by a third party entitled to disclose it; 

  

	 	c)	is already known to the receiving party at the time of disclosure by the disclosing party as shown by its prior written records; 

  

	 	d)	is developed independently by an employee or consultant of the receiving party who had no knowledge of disclosures made under this Agreement; or 

 

	 	e)	is required to be disclosed in compliance with a governmental regulation or judicial or administrative process. 

  

	 	6.2	No right or license, either expressed or implied, under any patent or other intellectual property right is granted hereunder. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	6.3	The obligations of confidentiality and non-disclosure shall remain in effect and survive for a period of five (5) years from the termination of this Agreement. 

ARTICLE VII 
 TERM AND
TERMINATION 
  

	 	7.1	The term of this Agreement shall be for 3 years commencing on the Effective Date. Provided this Agreement has not been terminated by SIGMA pursuant to Section 7.2 or 7.3, and upon mutual agreement by the parties
hereto, the Term of this Agreement may be extended for an additional three (3) years period upon written notice to SIGMA at less three (3) months prior to the expiration of the initial term. 

 

	 	7.2	If either party defaults in the performance or observation of any of its material obligations under this Agreement, the non-defaulting party may terminate this Agreement if such default is not cured within sixty
(60) days after written notice thereof, which notice shall contain a specific identification of the default. Failure to terminate this Agreement for any default or breach shall not constitute a waiver by the aggrieved party of its right to sue
for damages or its right to terminate this Agreement for any other default or breach. 

  

	 	7.3	Either party may terminate this Agreement upon written notice in the event that the other party files for bankruptcy, liquidation, dissolution, or takes similar action seeking protection against creditors under
insolvency laws, or has entered against it involuntarily a decree in bankruptcy or similar decree which remains in effect for sixty (60) days. 

  

	 	7.4	This Agreement may be terminated upon the mutual written agreement of the parties. 

  

	 	7.5	Upon termination of this Agreement, BUYER shall purchase Products from SIGMA for which SIGMA has outstanding purchase orders from BUYER (if so requested by SIGMA). 

 

	 	7.6	Upon termination of this Agreement, SIGMA shall deliver all Products to BUYER for which SIGMA has outstanding purchase orders from BUYER. 

ARTICLE VIII 
 TRADEMARKS AND
TRADE NAMES 
  

	 	8.1	BUYER and SIGMA hereby acknowledge that neither party now has and shall not hereafter acquire, any interest in any of the other party’s trademarks, trade names, service marks or logos appearing on the labels or
packaging materials containing the Product. No party shall, without the prior written consent of the affected party, use in advertising, publicity or otherwise, the name, trademark, logo, symbol or other image of the other party. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 Neither party will issue or disseminate any press release or statement, nor initiate any
communication of information regarding the existence or the terms of this Agreement, written or oral, to the communications media or a third party without the prior written consent of the other party. 

 

	 	8.2	The obligations of this Article shall remain in effect and survive the termination of this Agreement. 

ARTICLE IX 
 ASSIGNMENT AND
AMENDMENT 
  

	 	9.1	This Agreement may not be assigned by either party without the prior written consent of the other, except that either party may assign this Agreement to any corporation with which it may merge or consolidate, or to
which it may transfer all or substantially all of its assets to which this Agreement relates, without obtaining the consent of the other party, provided the assignee agrees to be bound, in written notice sent to the other party, by the terms and
conditions of this Agreement. Subject to the foregoing, this Agreement shall be binding upon and shall inure to the benefit of the parties hereto and their respective successors and assigns. 

 

	 	9.2	Except as otherwise provided herein, this Agreement may not be amended, supplemented or otherwise modified except by an instrument in writing signed by both parties. 

ARTICLE X 
 NOTICES 

 

	 	10.1	Any notice provided for under this Agreement shall be in writing, shall be deemed to have been sufficiently provided and effectively made as of the delivery date if hand-delivered, or as of the date received if sent by
courier service or mailed by registered or certified mail, postage prepaid, and addressed to the receiving party at its respective address as follows: 

If to BUYER: 
 RainDance
Technologies Inc. 
 44 Hartwell Avenue 

Lexington, MA 02421 
 Attention:
Jodi Tucker 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 To SIGMA-ALDRICH: 

SIGMA-ALDRICH, Inc. 
 3050
Spruce Street St. 
 Louis, Missouri 63103 

Fax. No:                      

Attn: Jesica Betts 
 And send a copy to: 

SIGMA-ALDRICH, 
 Genopole Campus
1 
 5, rue Henri Desbruères 

91030 Evry Cedex, France 
 St.
Louis, Missouri 63103 
 Fax. No: 33 1 60 87 59 09 

Attn: Khalil Arar 
 ARTICLE XI

 INDEPENDENT CONTRACTOR 
  

	 	11.1	The relationship of the parties under this Agreement is that of the independent contractors and not as agents of each other or parties or joint venturers, and neither party shall have the power to bind the other in any
way with respect to any obligation to any third party unless a specific power of attorney is provided for such purpose. Each party shall be solely responsible for its own employees and operations. 

ARTICLE XII 
 FORCE MAJEURE

  

	 	12.1	Neither party shall be liable to the other for failure to perform its obligations under this Agreement where such failure is caused by strikes, fires, hurricanes, embargoes, any governmental act or regulation, acts of
God, acts of war, insurrection, riot or civil disturbance, or any other cause not under the control of the defaulting party. If any event of force majeure should occur, the affected party shall promptly give notice thereof to the other party, and
the affected party shall use its best effort to cure or correct any such event of force majeure. 

 ARTICLE XIII 

MISCELLANEOUS 
  

	 	13.1	Should one of the provisions of this Agreement become or prove to be null and void, such will be without effect on the validity of this Agreement as a whole. Both parties will, however, endeavor to replace the void
provision by a valid one that in its economic effect is most consistent with the void provision. Both parties must agree to any such replacement provision in writing. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	13.2	This Agreement shall be governed by and construed in accordance with the laws of the State of Missouri without regard to principles of conflicts of laws. 

 

	 	13.3	This Agreement constitutes the entire understanding between the parties regarding the subject matter hereof and no party has relied on any representation not expressly set forth or referred to in this Agreement.

  

	 	13.4	Each party hereto agrees to executed, acknowledge and deliver such further instruments, and to do all such other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement.

  

	 	13.5	The waiver by either party of a breach of any provision contained herein shall be in writing and shall in no way be construed as a waiver of any succeeding breach of such provision or the waiver of the provision itself.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 IN WITNESS WHEREOF, the duly authorized representatives of the parties hereto have caused this
Agreement to be executed in duplicated originals. 
  

									
	SIGMA-ALDRICH, INC.	 		 	RainDance Technologies, Inc.
					
	By:	 	 /s/ Theresa S. Creasey
	 		 	By:	 	 /s/ Christopher McNary

	Name:	 	Theresa S. Creasey	 		 	Name:	 	Christopher McNary
	Title:	 	VP Operations & Marketing	 		 	Title:	 	President & CEO

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 EXHIBIT C 

PRICE, TAT & FORECAST 
  

	1)	Oligo Design and Synthesis forecast 

	 	a.	2009: [****] 

	 	b.	2010: [****] 

	 	c.	2011: [****] 

  

	2)	Turnaround Time (“TAT”) of the manufacturing of primers (does not include the design TAT) 

	 	a.	[****] 

	 	b.	[****] 

	 	c.	[****] 

  

	3)	Pricing 

	 	a.	[****] per [****]. 

	 	b.	Additional Services: RainDance Technologies may request additional services which may include custom formatting, preparation of custom buffers, etc. Any additional services will be priced at the time of the request.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 EXHIBIT D 

VENDOR QUALITY AGREEMENT 
  

					
	 Contents:
	  	 Section
	  	 Page

		  	Scope	  	1
		  	General	  	1
		  	Quality	  	1
		  	Documentation	  	2
		  	Feedback	  	2
		  	Process	  	2
		  	Inventory Management	  	3
		  	Packaging	  	3
		  	Labeling	  	3
		  	Shipping	  	3
		
	Scope:	  	Exhibit D is a component of the supplier support agreement and serves to cover the delivery of Quality and Compliance.
		
	General:	  	Sigma Custom Products remains bound by all applicable Raindance Technologies, and regulatory requirements, and is responsible for ensuring its compliance routinely.
		
		  	Sigma Custom Products shall have a documented quality system for managing all activities related to handling of Raindance Technologies Product.
		
	Quality:	  	Sigma Custom Products shall process products in accordance with specifications and directions agreed by Raindance Technologies as listed in a product-specific Process Request Record or similar specification document,
as set forth in Exhibit “A” (Excluding DNA Sequences).
		
		  	Sigma Custom Products will maintain any additional needed technical description of processing parameters in a product-specific Sigma Custom Products Process Specification Sheet or for the purposes of maintaining
change control, Sigma can list the procedure numbers and titles of the applicable SOP’s used to produce product.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

					
		
	 	  	Sigma Custom Products will perform the qualifications, operation and maintenance of process equipment,
calibration of process monitoring equipment, training of operating personnel, and
in accordance with Sigma’s
established quality system.
		
		  	Sigma Custom Products shall grant access for inspection/audit of its facilities, its Quality System and its production/inspection/test processes used for the production of Raindance Technology product.
		
		  	Sigma Custom Products shall inform Raindance Technologies in advance of any proposed changes to production processes and inspection procedures that directly impact Raindance Technology’s products. Sigma Custom
Products will obtain written approval from Raindance Technologies prior to implementing agreed upon changes.
		
	Documentation:	  	Product Design Records (Design History Files) and/or Technical File/Design Dossiers:
		
		  	The Sigma Custom Products shall provide to Raindance Technologies all necessary production process, inspection/test procedures, test data, labeling and other information as needed to prepare the Design History File
Technical File/Design Dossier for Raindance Technology product.
		
		  	Quality System Records:
		
		  	For Sigma Custom Products produced product, the Sigma Custom Products shall maintain all Quality System records (general procedures and documentation of activities not specific to a product) for Raindance Technology
product for a period of time consistent with Sigma Custom Products documented procedure. Sigma Custom Products shall provide documentation and/or records to Raindance Technology upon request.
		
		  	Record Retention:
		
		  	Sigma Custom Products shall maintain this documentation for a minimum period of 2 years unless otherwise requested.
		
	Feedback:	  	Sigma Custom Products shall inform Raindance Technologies of any complaints concerning Raindance Technologies product that it may receive. As appropriate, Raindance Technologies shall inform Sigma Custom Products of
complaint information relevant to Sigma Custom Products’s production/inspection processes.
		
		  	Sigma Custom Products shall investigate, determine appropriate Sigma Custom Products corrective action and inform Raindance Technologies in writing.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

					
		
	Process:	  	The table below depicts the processes/services performed by Sigma Custom Products

					
			
	 	  	 Process/Service
	  	 Description

			
		  	Review of customer requirements	  	Review design goals and design output sequences
			
		  	Process development	  	Design of custom processes used to produce & package RainDance Technologies’ products
			
		  	Receiving	  	Receiving of supplies and raw materials into vendor’s facility
			
		  	Manufacture	  	Synthesis and processing of product
			
		  	Inventory Management	  	Storage of product retains
			
		  	Packaging	  	Dispensing of product into containers suitable for shipping
			
		  	Labeling	  	Labeling of product containers
			
		  	Product Release & Shipping	  	Final quality control approval and physical shipment of product through shipping services

  

			
	Inventory Management:	  	Sigma Custom Products will perform Inventory Management activities, such as transactions, physicals, reporting, and environmental monitoring.
		
		  	[****].
		
		  	Sigma Custom Products shall maintain procedures detailing applicable activities regarding inventory practices.
		
	Packaging:	  	Sigma Custom Products will perform packaging activities for custom synthetic oligonucleotide solutions in designated packaging.
		
		  	Sigma Custom Products shall avoid rework that could compromise the primary package and shall minimize repacking (secondary level) wherever possible.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

			
		
		  	Sigma Custom Products shall have a documented system for managing packaging/repackaging operations and shall ensure that this system is employed on a continuing basis. Packaging materials, which contain labeling, shall be
properly controlled to prevent mix-ups.
		
	Labeling:	  	Sigma Custom Products shall have a documented system for managing labeling/re-labeling operations and shall ensure that this system is employed on a continuing basis.
		
	Shipping:	  	 Sigma Custom Products shall prepare and ship product according to established procedures.

 
 Sigma Custom Products shall record and maintain shipping transactions.

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 Amendment 1 to Supply Agreement 

This Amendment 1 is between RainDance Technologies, Inc. (“Buyer”) and Sigma-Genosys of Texas, LLC (“SIGMA”) 

WHEREAS, Buyer and SIGMA entered into a Supply Agreement effective February 24,2009 (the “Supply Agreement”), and 

WHEREAS, Buyer and SIGMA desire to extend and amend the Supply Agreement. NOW, THEREFORE, Buyer and SIGMA agree as follows: 

 

	1.	Defined terms used and not defined herein shall have the meanings ascribed to them in the Supply Agreement. 

  

	2.	The effective date of this Amendment 1 is February 24, 2012 (“Amendment 1 Effective Date”). 

  

	3.	Each reference in the Agreement and this Amendment 1, to “Sigma-Aldrich Inc.” and SIGMA shall be deemed to instead refer to “Sigma-Genosys of Texas, LLC,” and Sigma-Genosys of Texas, LLC hereby
assumes all rights, duties and obligations of Sigma-Aldrich Inc. under the Agreement and this Amendment 1 as if an original party thereto. Each party hereto acknowledges and agrees that this Amendment 1 shall constitute a novation of the obligations
of Sigma-Aldrich Inc. under the Agreement and this Amendment 1. Buyer recognizes Sigma-Genosys of Texas, LLC as the successor in interest in and to all of Sigma-Aldrich Inc.’s rights, duties and obligations under the Agreement and this
Amendment 1. 

  

	4.	The Supply Agreement is amended as follows: 

  

	 	a.	As of the Effective Date, Section 1.5 is hereby deleted in its entirety and replaced with: “Term” shall have the meaning set forth in Section 7.1.” 

 

	 	b.	As of the Amendment 1 Effective Date, Section 2.1 is hereby amended by deleting the first sentence and replacing it with the following: 

“Orders for Oligonucleotide synthesis will be placed by Buyer according to the process described in Exhibit B.” 

 

	 	c.	As of the Effective Date, Section 2.8 is hereby deleted in its entirety and replaced by the following: 

“Except as provided for under Section 4.5 regarding SIGMA’s indemnification obligations for third party claims, the remedies
described in Sections 2.5,2.6 and 2,7 shall be Buyer’s sole remedy and SIGMA’s only liability to Buyer hereunder with respect thereto. 
  

	 	d.	As of the Amendment 1 Effective Date, Sections 3.1 through and including 3.7 are hereby deleted in their entirety and replaced with the following: 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	3.1	The purchase price to be paid by Buyer for the Product is set forth in Exhibit C. The parties may [****] from time to time in accordance with Exhibit C. 

 

	 	3.2	By the [****] of [****], Buyer shall provide to [****] which shall [****] the [****] and the [****]. 

  

	 	3.3	Buyer shall make payments to SIGMA for the purchase price of Product within [****] after delivery thereof. 

  

	 	3.4	Buyer shall [****]. For clarity, Buyer [****]. 

  

	 	e.	As of the Effective Date, Section 6.1 is hereby amended by adding the following new paragraph at the end of the section: 

“For clarity, Confidential Information disclosed pursuant to Section 6,1(e) and is subject to a protective order or other
confidential treatment shall remain Confidential Information hereunder. Further, prior to disclosing Confidential Information pursuant to Section 6.1(e), the receiving party will give the disclosing party prompt written notice of the relevant
regulation or process and the receiving party shall take all reasonable and lawful actions to avoid or minimize the degree of disclosure. The receiving party will reasonably cooperate with the disclosing party in any efforts to seek a protective
order or other confidential treatment.” 
  

	 	f.	As of the Effective Date, Section 7.1 is hereby deleted in its entirety and replaced with the following: 

“Subject to earlier termination in accordance with this Section 7, the initial term of this Agreement shall be for a period of
5 years commencing on the Effective Date and the term shall automatically extend for successive 1 year terms thereafter unless either party provides written notice of non-renewal at least thirty (30) days prior to the expiration of the
then current term (the “Term”).” 
  

	 	g.	As of the Amendment 1 Effective Date, Section 10.1 is hereby amended by replacing Buyer’s address with the following address for the purpose of notices: 

“If to Buyer: 
 RainDance
Technologies, Inc. 
 44 Hartwell Avenue 

Lexington, MA 02421 
 Attn:
Chief Executive Officer 
 And send a copy to: 

RainDance Technologies, Inc. 

44 Hartwell Avenue 
 Lexington,
MA 02421 
 Attn: Senior Vice President, Operations” 
  

	 	h.	For purposes of all orders placed on after the Amendment 1 Effective Date, (i) Exhibits A, B and C originally attached to the Supply Agreement are deleted in their entirety and replaced with Exhibits A, B, and C
attached to this Amendment 1. 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

	 	i.	As of the Amendment 1 Effective Date, Exhibit D is hereby amended as follows: 

  

	 	i.	The first sentence in the “Feedback” section is deleted, and 

  

	 	ii.	The phrase “Review design goals and design output sequences” at row 1 (under the column titles), column 2 of the table in the “Process” section is replaced with the phrase “Review purchase
orders and RainDance Technologies provided design sequences”. 

  

	 	j.	As of the Effective Date, all references to “Sigma Custom Products” in Exhibit D shall be deemed to be references to Sigma-Genosys of Texas, LLC. 

 

	5.	Except as expressly set forth herein, all other terms and conditions of the Supply Agreement shall remain unchanged and continue in full force and effect. This Amendment 1 amends and is hereby made a part of the Supply
Agreement. 

  

	6.	This Amendment 1 may be signed in counterparts, each of which shall be deemed an original and all of which together shall constitute one agreement. Facsimile or pdf image signatures shall be treated as original
signatures. 

 IN WITNESS WHEREOF, each party has caused this Amendment 1 to be executed by its duly authorized representative as of the
Amendment 1 Effective Date. 
  

									
	RAINDANCE TECHNOLOGIES, INC.	 		 	SIGMA-GENOSYS OF TEXAS, LLC
					
	By:	 	 /s/ S. Roopom Banerjee
	 		 	By:	 	 /s/ Theresa S. Creasey

	S. Roopom Banerjee	 		 	Print Name: Theresa S. Creasey
	President and Chief Executive Officer	 		 	Title:	 	Vice President, Sigma Custom Products

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 EXHIBIT C 

PRICE, TAT & FORECAST 
  

	1)	Turnaround Time (“TAT”) of the manufacturing primers. The term “Turnaround Time” shall mean the number of business days from the day of order receipt by SIGMA to the day of shipment to Buyer.

 SINGLEPLEX 
  

									
	 # of amplicons

(low)
	 	 # of amplicons

(high)
	 	 # of aligos

(low)
	 	 # of oligos

(high)
	 	 TAT

(<2 orders w/in 24 hr)

	[****]	 	[****]	 	[****]	 	[****]	 	[****]
					
	[****]	 	[****]	 	[****]	 	[****]	 	[****]
					
	[****]	 	[****]	 	[****]	 	[****]	 	[****]
					
	[****]	 	[****]	 	[****]	 	[****]	 	[****]
					
	[****]	 	[****]	 	[****]	 	[****]	 	[****]

 MULTIPLEX 
  

									
	 # of amplicons

(low)
	 	 # of amplicons

(high)
	 	 # of oligos

(low)
	 	 # of oligos

(high)
	 	 TAT

(<2 orders w/in 24 hr)

	 [****]
	 	[****]	 	[****]	 	[****]	 	[****]
					
	 [****]
	 	[****]	 	[****]	 	[****]	 	[****]
					
	 [****]
	 	[****]	 	[****]	 	[****]	 	[****]
					
	 [****]
	 	[****]	 	[****]	 	[****]	 	[****]
					
	 [****]
	 	[****]	 	[****]	 	[****]	 	[****]

  

	2)	Pricing 

 Subject to the remainder of this paragraph, the pricing set forth below shall be binding for [****].
Ninety (90) days prior to the end of the then-current pricing term, the parties shall meet to discuss future pricing, and if applicable, whether the Term of the Agreement will continue. The parties intend to agree on pricing for subsequent
years prior to expiration of the then-current pricing. In the event that the parties do not agree on such revised pricing, the current pricing will be increased or decreased, as applicable, by [****]. 

Example: If the parties cannot agree on pricing for the period beginning on [****]. The change was calculated as follows: 

[****] 
 [****] 

[****] 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION. 

 Standard pricing for custom and defined content libraries (Price per base): 

[****] 
 [****] 

[****] 
 [****] 

[****] 
 Pricing for large scale synthesis runs:

  

	 	1.	SIGMA and RDT intend to initiate a new pricing program for those opportunities that allow for larger synthesis scale to be utilized. The pricing program is called MegaDx. The following pricing is documented as initial
pricing. [****]. 

  

	 	2.	Programs that qualify for MegaDx pricing require that RDT provide SIGMA with a firm PO for the full quantity. Shipment of product from SIGMA to RDT will be spread over [****]. 

[Intentionally Blank to Bottom of Page] 

  
 CONFIDENTIAL TREATMENT REQUESTED
UNDER C.F.R. SECTIONS 200.80(b)(4), 200.83 AND 230.406. [****] INDICATES OMITTED MATERIAL THAT IS THE SUBJECT OF A CONFIDENTIAL TREATMENT REQUEST FILED SEPARATELY WITH THE COMMISSION. THE OMITTED MATERIAL HAS BEEN FILED SEPARATELY WITH THE
COMMISSION.

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