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                                                                    EXHIBIT 10.6

                                   AMENDMENT

                                     TO THE

                          DATATRAK INTERNATIONAL, INC.

          AMENDED AND RESTATED 1996 OUTSIDE DIRECTORS STOCK OPTION PLAN

         This Amendment (the "Amendment") to the DATATRAK International, Inc.
Amended and Restated 1996 Outside Directors Stock Option Plan is made this 18th
day of December, 2001 by DATATRAK International, Inc. (the "Company").

                               W I T N E S S E T H

         WHEREAS, the Company's Board of Directors adopted the Company's Amended
and Restated 1996 Outside Directors Stock Option Plan (the "Plan") on February
29, 1996; and

         WHEREAS, the Plan was approved at a meeting of the Company's
shareholders on May 2, 1996; and

         WHEREAS, the Company, as a condition to the consummation of a private
placement of the Company's common shares and pursuant to the terms of a Share
Purchase Agreement among the Company and the investors parties thereto, has
agreed to amend each of its stock option plans to place certain restrictions on
the granting of stock options; and

         WHEREAS, the Board of Directors has deemed it necessary and appropriate
to adopt such amendments to each of the Company's stock option plans to place
certain restrictions on the granting of stock options.

         NOW, THEREFORE, in consideration of the foregoing, the Plan is amended
as follows:

         CERTAIN RESTRICTIONS. The following language shall be added to the Plan
as a new section:

                  "Notwithstanding anything in the foregoing to the contrary,
         the Company shall not, unless approved by the holders of a majority of
         the shares present and entitled to vote at a duly convened meeting of
         shareholders:

         (i)      grant any stock option, including stock appreciation right,
                  with an exercise price that is less than 100% of the fair
                  market value of the underlying stock on the date of grant; or

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         (ii)     reduce the exercise price of any stock option, including stock
                  appreciation right, outstanding or to be granted in the
                  future; cancel and re-grant options at a lower exercise price
                  (including entering into any "6 month and 1 day" cancellation
                  and re-grant program), whether or not the canceled options are
                  put back into the available pool for grant; replace
                  out-of-the-money options with restricted stock in an exchange,
                  buy-back or other program; or replace any options with new
                  options having a lower exercise price or accelerated vesting
                  schedule in an exchange, buy-back or other program.

         The prohibitions set forth in items (i) and (ii) above may not be
         further amended or repealed without the affirmative vote of the holders
         of a majority of the shares present and entitled to vote at a duly
         convened meeting of shareholders."

         IN WITNESS WHEREOF, DATATRAK International, Inc., by its appropriate
officers duly authorized, has executed this Amendment as of the 18th day of
December, 2001.

                                DATATRAK INTERNATIONAL, INC.

                                By:      /s/ JEFFREY A. GREEN
                                   --------------------------------------------
                                Jeffrey A. Green, President and Chief Executive
                                   Officer

                                By:      /S/ TERRY C. BLACK
                                   --------------------------------------------
                                Terry C. Black, Vice President of Finance, Chief
                                   Financial Officer, Treasurer and Assistant
                                   Secretary

                                       2<PAGE>

                                                                    EXHIBIT 10.8

                                   AMENDMENT

                                     TO THE

                          DATATRAK INTERNATIONAL, INC.

                 AMENDED AND RESTATED 1992 SHARE INCENTIVE PLAN

         This Amendment (the "Amendment") to the DATATRAK International, Inc.
Amended and Restated 1992 Share Incentive Plan is made this 18th day of
December, 2001 by DATATRAK International, Inc. (the "Company").

                               W I T N E S S E T H

         WHEREAS, the Company's Board of Directors adopted the Company's Amended
and Restated 1992 Share Incentive Plan (the "Plan") on September 23, 1992; and

         WHEREAS, the Plan was approved by action of the Company's shareholders
on September 23, 1992; and

         WHEREAS, the Company, as a condition to the consummation of a private
placement of the Company's common shares and pursuant to the terms of a Share
Purchase Agreement among the Company and the investors parties thereto, has
agreed to amend each of its stock option plans to place certain restrictions on
the granting of stock options; and

         WHEREAS, the Board of Directors has deemed it necessary and appropriate
to adopt such amendments to each of the Company's stock option plans to place
certain restrictions on the granting of stock options.

         NOW, THEREFORE, in consideration of the foregoing, the Plan is amended
as follows:

         CERTAIN RESTRICTIONS. The following language shall be added to the Plan
as a new section:

                  "Notwithstanding anything in the foregoing to the contrary,
         the Company shall not, unless approved by the holders of a majority of
         the shares present and entitled to vote at a duly convened meeting of
         shareholders:

         (i)      grant any stock option, including stock appreciation right,
                  with an exercise price that is less than 100% of the fair
                  market value of the underlying stock on the date of grant; or

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         (ii)     reduce the exercise price of any stock option, including stock
                  appreciation right, outstanding or to be granted in the
                  future; cancel and re-grant options at a lower exercise price
                  (including entering into any "6 month and 1 day" cancellation
                  and re-grant program), whether or not the canceled options are
                  put back into the available pool for grant; replace
                  out-of-the-money options with restricted stock in an exchange,
                  buy-back or other program; or replace any options with new
                  options having a lower exercise price or accelerated vesting
                  schedule in an exchange, buy-back or other program.

         The prohibitions set forth in items (i) and (ii) above may not be
         further amended or repealed without the affirmative vote of the holders
         of a majority of the shares present and entitled to vote at a duly
         convened meeting of shareholders."

         IN WITNESS WHEREOF, DATATRAK International, Inc., by its appropriate
officers duly authorized, has executed this Amendment as of the 18th day of
December, 2001.

                                DATATRAK INTERNATIONAL, INC.

                                By:      /s/ JEFFREY A. GREEN
                                   --------------------------------------------
                                Jeffrey A. Green, President and Chief Executive
                                   Officer

                                By:      /s/ TERRY C. BLACK
                                   --------------------------------------------
                                Terry C. Black, Vice President of Finance, Chief
                                   Financial Officer, Treasurer and Assistant
                                   Secretary

                                       2<PAGE>
                                                                   EXHIBIT 10.10

                                 AMENDMENT NO. 1
                                     TO THE
                     COLLABORATIVE CLININCAL RESEARCH, INC.
                   AMENDED AND RESTATED 1996 KEY EMPLOYEES AND
                          CONSULTANTS STOCK OPTION PLAN

         This Amendment No. 1 (the "Amendment") to the Collaborative Clinical
Research, Inc. Amended and Restated 1996 Key Employees and Consultants Stock
Option Plan is made this 20th day of May, 1997 by the Board of Directors of
Collaborative Clinical Research, Inc. (the "Company").

                               W I T N E S S E T H

         WHEREAS, the Company's Board of Directors adopted the Company's Amended
and Restated 1996 Key Employees and Consultants Stock Option Plan (the "Plan")
on February 29, 1996; and

         WHEREAS, the Plan was approved at a meeting of the Company's
shareholders on May 2, 1996; and

         WHEREAS, the Plan provided for up to 182,667 common shares ("Common
Shares") available for grant under the Plan; and

         WHEREAS, the Company desires to amend the Plan to increase the number
of Common Shares authorized for issuance under the Plan from 182,667 Common
Shares to 557,667 Common Shares in order to further the purposes of the Plan.

         NOW, THEREFORE, in consideration of the foregoing, the Plan is amended
as follows:

         SHARES SUBJECT TO THE PLAN. The first paragraph of Section 6 of the
Plan is deleted in its entirety and the following paragraph is substituted in
lieu thereof:

         "Subject to the provisions of Section 9 concerning payment for stock
appreciation rights in Common Shares and subject to the provisions of the next
succeeding paragraph of this Section 6, the aggregate number of Common Shares
for which options may be granted under the Plan shall be 557,667 Common Shares.
Either treasury or authorized and unissued Common Shares, or both, in such
amounts, within the maximum limits of the Plan, as the Committee shall from time
to time determine, may be so issued. All Common Shares which are the subject of
any lapsed, expired or terminated options may be made available for reoffering
under the Plan to any Key Employee or Consultant. If an option granted under
this Plan is exercised pursuant to the terms and conditions determined by the
Committee under Subsection 7(d), and a stock appreciation right is not granted
in conjunction with the option pursuant to Section 9, any Common Shares which
are the subject thereof shall not thereafter be available for reoffering under
the Plan to any Key Employee or Consultant. If a stock appreciation right is
granted in conjunction with an option pursuant to Section 9, and if the option
agreement with the Optionee provides that exercise of the stock appreciation
right shall be in lieu of exercise of the options, and the stock appreciation
right is thereafter exercised in whole or in part, then the option or the
portion thereof with respect to which the stock appreciation right was exercised
shall be deemed to have been exercised and the Common Shares which otherwise
would have been issued upon exercise of such option, to the extent not used in
payment for the stock appreciation rights, may be made available for reoffering
under the Plan to any Key Employee or Consultant."

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