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Exhibit 10.25

	

    	

    	

    	

    	

    
	AWARD/CONTRACT
	1. 	THIS
          CONTRACT IS A RATED ORDER 

    UNDER
    DPAS (15 CFR 350) 	                      Rating  

                          N/A	   PAGE     OF    PAGES

           1         |          26
	
	
	
	
	

	2.   CONTRACT (Proc
    Inst. Ident.) NO.

                N01-AI-30030      	3.	EFFECTIVE DATE

    September
    26, 2003 	4.  REOUISITION/PURCHASE
          REQUEST/PROJEOT NO.

            VR 071 
	
	
	
	

    

	5. 	ISSUED
    BY

    
        National
        Institutes of Health

           Contract Management Branch, NIAID 

         Room 2230 

         6700-B Rockledge
      Dr., MSC 7612 

         Bethesda, Maryland 20892-7612 
        	CODE
               2668-30030	6.	ADMINISTERED
BY (If other than Item 6)

    DAIDS / VR

    

    RFP NIH-NIAID-DAIDS-03-12   
	CODE 
	
	
	
	
	
	

	7.	NAME AND ADDRESS OF CONTRACTOR (No, street, county, state and ZIP code)	8. 
  DELIVERY
	 	 	       FOB
    ORIGIN          OTHER
    (see below)

                                                 FOB Destination    
	 	 	 
	 	Progenics Pharmaceuticals, Inc.

777  Old
Saw Mill River Road

Tarrytown. NY
10591	9.    DISCOUNT
    FOR PROMPT PAYMENT

          N/A

	 	 	10.  SUBMIT
    INVOICES                         ITEM

	 	 CODE 	FACILITY
      CODE 	ADDRESS
          SHOWN IN:                        Art.
          G.3.
	
	
	
	

	11. 	SHIP
          TO/MARK FOR

      

             See
      Article F.1.
	CODE            N/A 	12.	PAYMENT
          WILL BE MADE BY

      

        See Article
        G.3. 
	CODE
                N/A 
	
	
	
	
	
	

	13. 	AUTHORITY FOR USING OTHER
    FULL AND OPEN COMPETITION: 	14.	ACCOUNTING AND APPROPRIATION
        DATA:
EIN 1-133379479-A1;
	 	  10
    U.S.C. 2304(c) (     )	    41
    U.S.C. 253(c) (     )	 	CAN 3-8425874; $3,054,013; SOCC
    25.55; DOC #300N1AI30030A

	
	
	
	
	
	

	15A.  ITEM
          NO.
	15B.
    SUPPLIES/SERVICES
	15C.
    QUANTITY
	15D.
    UNIT 
	15E.
    UNIT PRICE
	15F.
    AMOUNT

	
	
	
	
	
	

	Research
          and Development Contract	FY'03	$3,054,013	 	
	Title:
          HIV Vaccine Design and Development Teams (HVDDT)	FY'04	$3,351,512	 	
	Period:
          September 26, 2003 through September 25, 2008	FY'05	$6,797,463	 	
	Amount
          Allotted: $3,054,013	FY'06	$7,503,388	 	
	Contract
          Type: Cost-Plus-Fixed-Fee (Completion)	FY'07	$7,855,282	 	
	
	
	
	
	

	15G.
    TOTAL AMOUNT OF CONTRACT
	    
	$28,561,658
	
	
	
	
	

	16.
    TABLE OF CONTENTS

	
	
	
	
	
      

    
	
	
	

		 SEC.	 DESCRIPTION
	 PAGE(S) 		SEC.	DESCRIPTION	PAGE(S) 

	
	
	
	
	
	
	
	

	 	 	PART
    I – THE SCHEDULE
	 	
	 	PART
    II – CONTRACT CLAUSES
	

	
	
	
	
	
	
	
	

		A
	SOLICITATION/CONTRACT FORM	1
		I
	CONTRACT CLAUSES	20

	
  

	
  

  
	
  
	
  

	  

	
  

	
  
	
  

		B
	SUPPLIES OR SERVICES AND PRICE/COST	4
	 
	 
	PART III – LIST
    OF DOCUMENTS, EXHIBITS AND OTHER ATTACH.	 

	
  

	
  

	
  
	
  

	  

	
  

	
  
	
  

		C
	DESCRIPTION/SPECS/WORK STATEMENT	8
		J
	LIST
    OF ATTACHMENTS	25

	
  

	
  

	
  
	
  

	  

  	
  

	
  
	
  

		D
	PACKAGING AND MARKING	10
	 
	 
	PART IV – REPRESENTATIONS AND INSTRUCTIONS	 

	
  

	
  

  
	
  
	
  

	  

	
  

	
  
	
  

		E
	INSPECTION AND ACCEPTANCE	10
		K
	REPRESENTATIONS, CERTIFICATIONS AND OTHER STATEMENTS OF OFFERORS	26

	
  

  
	
  

  
	
  
	
  

  
	  

	
  

  
	
  
	
  

		F
	DELIVERIES OR PERFORMANCE	11
	 
	 
	 	 

	
  

	
  

  
	
  
	
  

	  

  	
  

	
  
	
  

		G
	CONTRACT ADMINISTRATION DATA	12
		L
	INSTRS., CONDS. AND NOTICES TO OFFERORS	 

	
  

  
	
  

  
	
  
	
  

  
	  

	
  

	
  
	
  

		H
	SPECIAL CONTRACT REQUIREMENTS	15
		M
	EVALUATION FACTORS FOR AWARD	 

	
	
	
	
	
	
	
	

	CONTRACTING
    OFFICER WILL COMPLETE ITEM 17 OR 18 AS APPLICABLE 

	
	
	
	
	
	
	
	

	17.    CONTRACTOR’S
      NEGOTIATED AGREEMENT (Contractor is required
      to sign this document and return 2 copies to issuing office.) Contractor
      agrees to furnish and deliver all items or perform
    all the services set forth or otherwise identified above and on any continuation
    sheets for the consideration stated herein. The rights and obligations of
      the parties to this contract shall be subject to and governed by the following
    documents: (a) this award/contract, (b)
    the solicitation, if any, and (c) such provisions, representations, certifications,
    and specifications, as are attached or incorporated by reference herein.
    (Attachments are listed herein.)
	18.   AWARD
      (Contractor is not required to sign this document.) Your offer on Solicitation
      Number ______________, including the additions or changes made by you which
      additions or changes are set forth in full above, is hereby accepted as
      to the Items listed above and on any continuation sheets. This award consummates
      the contract which consists of the following documents: (a) the Government’s
      solicitation and your offer, and (b) this award/contract. No further contractual
    document is necessary, 

	
	
	
	

	19A.  	NAME AND TITLE OF SIGNER (Type or print)

    Robert A. McKinney, Vice President    

    	20A.  	NAME OF CONTRACTING OFFICER

      Nancy M. Hershey

    Contracting Officer, CMB, DEA, NIAID, NIH, DHHS

	
	

    	
	

    	

    	

	19B.  	NAME OF CONTRACTOR	19C. DATE SIGNED	20B.  	UNITED STATES OF
    AMERICA	20C. DATE SIGNED
	 	

PROGENICS PHARMACEUTICALS, INC.

                                            /s/ Robert A. McKinney

        

      (Signature
    of person authorized to sign)
	9/24/03	By	/s/ Nancy M. Hershey
        

      (Signature of Contracting
    Officer)	9/25/03
	
	
	
	
	
	

	NSN 7540-01-152-8069
PREVIOUS EDITION UNUSABLE	26-107

  Computer Generated	STANDARD FORM 26 (REV. 4-85)

Prescribed by GSA

FAR
    (48 CFR) 53.214(a)

N01-AI-30030

DETAILED TABLE OF CONTRACT CONTENTS

	PART I- THE SCHEDULE 	 
	 	 	 	 
	 	SECTION A – SOLICITATION/CONTRACT
          FORM 	 
	 	 	 	 
	 	SECTION
            B – SUPPLIES
          OR SERVICES AND PRICES/COSTS	4
	 	 	ARTICLE B.1. BRIEF DESCRIPTION
        OF SUPPLIES OR SERVICES	4
	 	 	ARTICLE B.2. ESTIMATED COST
        AND FIXED FEE	4
	 	 	ARTICLE B.3. PROVISIONS APPLICABLE
        TO DIRECT COSTS	4
	 	 	ARTICLE B.4. ADVANCE UNDERSTANDINGS	5
	 	 	 	 

    
	 	SECTION C – DESCRIPTION/SPECIFICATIONS/WORK
    STATEMENT	8
	 	 	ARTICLE C.1. STATEMENT OF WORK	8
	 	 	ARTICLE C.2. REPORTING REQUIREMENTS	8
	 	 	ARTICLE C.3. INVENTION REPORTING
        REQUIREMENT	10
	 	 	 	 

    
	 	SECTION
            D – PACKAGING,
          MARKING AND SHIPPING	10
	 	 	 	 

    
	 	SECTION
            E – INSPECTION
          AND ACCEPTANCE	10
	 	 	 	 

    
	 	SECTION
            F – DELIVERIES
          OR PERFORMANCE	11
	 	 	ARTICLE
    F.1. DELIVERIES
	11
	 	 	ARTICLE
    F.2. CLAUSES INCORPORATED BY REFERENCE
	12
	 	 	 	 

    
	 	SECTION
            G – CONTRACT
          ADMINISTRATION DATA	12
	 	 	ARTICLE
    G.1. PROJECT OFFICER
	13
	 	 	ARTICLE
    G.2. KEY PERSONNEL
	13
	 	 	ARTICLE
          G.3. INVOICE SUBMISSION/CONTRACT FINANCING REQUEST AND CONTRACT FINANCIAL
    REPORT
	13
	 	 	ARTICLE
    G.4. INDIRECT COST RATES
	13
	 	 	ARTICLE
    G.5. GOVERNMENT PROPERTY
	14
	 	 	ARTICLE
    G.6. POST AWARD EVALUATION OF CONTRACTOR PERFORMANCE
	14
	 	 	 	 

    
	 	SECTION
            H – SPECIAL
          CONTRACT REQUIREMENTS	15
	 	 	ARTICLE
          H.1. REIMBURSEMENT OF COSTS FOR INDEPENDENT RESEARCH AND DEVELOPMENT
    PROJECTS
	15
	 	 	ARTICLE
    H.2. RESTRICTION FROM USE OF HUMAN SUBJECTS
	15
	 	 	ARTICLE
    H.3. REQUIRED EDUCATION IN THE PROTECTION OF HUMAN RESEARCH PARTICIPANTS
	15
	 	 	ARTICLE
    H.4. DATA AND SAFETY MONITORING IN CLINICAL TRIALS
	15
	 	 	ARTICLE
    H.5. HUMAN MATERIALS
	16
	 	 	ARTICLE
    H.6. CONTINUED BAN ON FUNDING OF HUMAN EMBRYO RESEARCH
	16
	 	 	ARTICLE
    H.7. NEEDLE EXCHANGE
	16
	 	 	ARTICLE
    H.8. PRIVACY ACT
	16
	 	 	ARTICLE
    H.9. INTRODUCTION OF RODENTS AND RODENT PRODUCTS
	17
	 	 	ARTICLE
    H.10. ANIMAL WELFARE
	17
	 	 	ARTICLE
    H.11. RESTRICTION FROM USE OF LIVE VERTEBRATE ANIMALS
	17
	 	 	ARTICLE
    H.12. SALARY RATE LIMITATION LEGISLATION PROVISIONS
	17
	 	 	ARTICLE
    H.13. PUBLICATION AND PUBLICITY
	18
	 	 	ARTICLE
    H.14. PRESS RELEASES
	18
	 	 	ARTICLE
    H.15. REPORTING MATTERS INVOLVING FRAUD, WASTE AND ABUSE
	18
	 	 	ARTICLE
    H.16. ANTI-LOBBYING
	18
	 	 	ARTICLE
    H.17. OBTAINING AND DISSEMINATING BIOMEDICAL RESEARCH RESOURCES
	19
	 	 	ARTICLE
    H.18. PROHIBITION ON CONTRACTOR INVOLVEMENT WITH TERRORISM ACTIVITIES
	19
	 	 	 	 
	

        PART II-
        CONTRACT CLAUSES

    	20

 

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N01-Al-30030

	 	SECTION
            I – CONTRACT
    CLAUSES	20

    
	 	 	ARTICLE
          I.1. GENERAL CLAUSES FOR A COST-REIMBURSEMENT RESEARCH AND DEVELOPMENT
    CONTRACT
	20

    
	 	 	ARTICLE
    I.2. AUTHORIZED SUBSTITUTION OF CLAUSES
	23

    
	 	 	ARTICLE
    I.3. ADDITIONAL CONTRACT CLAUSES
	23

    
	 	 	ARTICLE
    I.4. ADDITIONAL FAR CONTRACT CLAUSES INCLUDED IN FULL TEXT
	24

    
	 	 	 	 	 

    
	PART III	25

    
	 	 	 	 	 

    
	 	SECTION
            J – LIST
        OF ATTACHMENTS	25

    
	 	 	1. 	Statement
    of Work
	25

    
	 	 	2. 	Invoice/Financing
          Request and Contract Financial Reporting Instructions for NIH Cost-Reimbursement
    Type Contracts
	25

    
	 	 	3. 	Inclusion
    Enrollment Report
	25

    
	 	 	4. 	Annual
    Technical Progress Report Format for Each Study
	25

    
	 	 	5.	 Safety
    and Health
	25

    
	 	 	6.	 Research
    Patient Care Costs
	25

    
	 	 	7. 	Procurement
    of Certain Equipment
	25

    
	 	 	 	 	 

    
	PART IV 	26

    
	 	 	 	 	 

    
	 	SECTION
            K – REPRESENTATIONS
          AND CERTIFICATIONS	26

    
	 	 	1. 	Representations
    and Certifications
	26

    
	 	 	2. 	Human
    Subjects Assurance Identification Number
	26

    
	 	 	3. 	Animal
    Welfare Assurance Number
	26

    
	 	 	 	 	 

    

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N01-AI-30030

SECTION B – SUPPLIES OR SERVICES
      AND PRICES/COSTS 

ARTICLE B.1. BRIEF DESCRIPTION
      OF SUPPLIES OR SERVICES 

The purpose of this contract is the
    development of an efficacious vaccine against HIV for worldwide use in stemming
    the AIDS epidemic. 

ARTICLE B.2. ESTIMATED COST AND
      FIXED FEE 

	a.	The estimated cost of this contract is $26,944,960.
	 	 
	b. 	The fixed fee for this contract
          is $1,616,698. The fixed fee shall be paid in installments based on
          negotiated milestones set forth in Article B.4.e. and subject to withholding
          provisions of the clauses ALLOWABLE COST AND PAYMENT AND FIXED FEE
          Referenced in the General Clause Listing in Part II, ARTICLE I.1. of
          this contract.

    
	 	 
	c. 	The Government’s obligation,
          represented by the sum of the estimated cost plus fixed fee, is $28,561,658.

    
	 	 
	d. 	Total funds currently available
          for payment and allotted to this contract are $3,054,013, of which
          $2,881,144, represents the estimated costs, and of which $172,869 represents
          the fixed fee. For further provisions on funding, see the LIMITATION
          OF FUNDS clause referenced in Part
          II, ARTICLE I.2. Authorized Substitutions of Clauses.

    
	 	 
	e.	It is estimated that the
          amount currently allotted will cover performance
          of the contract through September 25, 2004.

    
	 	 
	f .	The Contracting Officer may
          allot additional funds to the contract without the concurrence of the
          Contractor.

    
	 	 
	g.	Future increments to be allotted
          to this contract are estimated as follows:

    
	 	 

	 	FY	PERIOD

    	  ESTIMATED
            COST

    	 FIXED
            FEE 

    	TOTAL
            AMOUNT

    
	 	 	 	 	 	 
	 	04	09/26/04 – 09/25/05

    	 $3,161,804

    	 $189,708

    	 $3,351,512

    
	 	05	09/26/05 – 09/25/06

    	 $6,412,701

    	 $384,762

    	 $6,797,463

    
	 	06	09/26/06 – 09/25/07

    	 $7,078,668

    	 $424,720

    	 $7,503,388

    
	 	07	09/26/07 – 09/25/08

    	 $7,410,643

    	 $444,639

    	 $7,855,282

    

ARTICLE B.3. PROVISIONS APPLICABLE
      TO DIRECT COSTS 

	a.	Items Unallowable Unless Otherwise
        Provided
	 	 	 
	 	Notwithstanding the clauses,
          ALLOWABLE COST AND PAYMENT, and FIXED FEE, incorporated in this contract,
          unless authorized in writing by the Contracting Officer, the costs
          of the following items or activities shall be unallowable as direct
          costs:

    
	 	 	 
	 	(1)	 Acquisition, by purchase or lease, of any
        interest in real property; 
	 	 	 
	 	(2) 	Special rearrangement or alteration of facilities; 
	 	 	 
	 	(3)	 Purchase or lease of any item of general
        purpose office furniture or office equipment regardless of dollar value.
        (General purpose equipment is defined as any items of personal property
        which are usable for purposes other than research, such as office equipment
        and furnishings, pocket calculators, etc.); 
	 	 	 
	 	(4)	 Travel to attend general scientific meetings; 
	 	 	 
	 	(5) 	Foreign travel – See Paragraph b.(2)
        below; 
	 	 	 
	 	(6) 	Consultant costs; 

 

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N01-AI-30030

	 	(7) 	Subcontracts;

    
	 	 	 	 
	 	(8)	 Patient care costs; 
	 	 	 	 
	 	(9)	 Accountable Government property (defined
        as both real and personal property with an acquisition cost of $1,000
        or more and a life expectancy of more than two years) and “sensitive
        items“ (defined and listed in the Contractor’s Guide for Control
    of Government Property), 1990, regardless of acquisition value. 
	 	 	 	 
	b.	Travel Costs
	 	 	 	 
	 	(1)	 Domestic Travel 
	 	 	 	 
	 	 	(a) 	Total expenditures for domestic travel (transportation,
        lodging, subsistence, and incidental expenses) incurred in direct performance
        of this contract shall not exceed $26,387 without the prior written
        approval of the Contracting Officer.
	 	 	 	 
	 	 	(b) 	The Contractor shall invoice
          and be reimbursed for all travel costs in accordance with Federal Acquisition
          Regulations (FAR) 31.205-46.

    
	 	 	 	 
	 	(2)	 Foreign Travel 
	 	 	 	 
	 	 	Requests for foreign
        travel must be submitted at least six weeks in advance and shall contain
        the following: (a) meeting(s) and place(s) to be visited, with costs
        and dates; (b) name(s) and title(s) of Contractor personnel to travel
        and their functions in the contract project; (c) contract purposes to
        be served by the travel; (d) how travel of contractor personnel will
        benefit and contribute to accomplishing the contract project, or will
        otherwise justify the expenditure of NIH contract funds; (e) how such
        advantages justify the costs for travel and absence from the project
        of more than one person if such are suggested; and (f) what additional
        functions may be performed by the travelers to accomplish other purposes
        of the contract and thus further benefit the project. 
	 	 	 	 
	ARTICLE B.4.
          ADVANCE UNDERSTANDINGS 
	 	 	 	 
	Other provisions
        of this contract notwithstanding, approval of the following items within
        the limits set forth is hereby granted without further authorization
        from the Contracting Officer. 
	 	 	 	 
	a. 	Confidential Treatment
        of Sensitive Information
	 	 	 	 
	 	The
          Contractor shall guarantee strict confidentiality of the information/data
          that is provided by
          the Govemment during the performance of the contract. The Government
          has determined that the information/data that the Contractor will be
          provided during the performance of the contract is of a sensitive nature.

    
	 	 	 	 
	 	Disclosure of the
        information/data, in whole or in part, by the Contractor can only be
        made after the Contractor receives prior written approval from the Contracting
        Officer. Whenever the Contractor is uncertain with regard to the proper
        handling of information/data under the contract, the Contractor shall
        obtain a written determination from the
    Contracting Officer.
	 	 	 	 
	b.	Subcontracts
	 	 	 	 
	 	(1)	 To negotiate a cost-reimbursenent type subcontract
        with Weill Medical College of Cornell University for an amount not to
        exceed $2,153,159. Award of the subcontract shall not proceed without
        the prior written approval of the Contracting Officer upon review of
        the draft subcontract. After written approval of the subcontract by the
        Contracting Officer, a copy of the signed, approved subcontract shall
    be provided to the Contracting Officer. 
	 	 	 	 

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N01-AI-30030

	 	(2) 	To negotiate a cost-reimbursement type subcontract
        with the Tulane Regional Primate Research Center for an amount not to
        exceed $1,685,605. Award of the subcontract shall not proceed without
        the prior written approval of the Contracting Officer upon review of
        the draft subcontract. After written approval of the subcontract by the
        Contracting Officer, a copy of the signed, approved subcontract shall
        be provided to the Contracting Officer. 
	 	 	 
	c.	Consultants
	 	 	 
	 	The total amount
          set aside for consultants for Years 1-5 are as follows:

    
	 	 

	 	Year 1	Year 2	Year 3	Year 4	Year 5	Total
	 	$21,000	 $21,162	 $21,328	 $21,499	 $21,675	$106,664

	 	 
	Authorization to utilize consultants
        shall not proceed without the prior written approval of the Contracting
        Officer upon review of each individual consultant and a copy of each
    consultant agreement. 
	 	 
	d.	Indirect Costs
	 	 	 
	 	(1) 	In no event shall the final amount reimbursable
        for indirect costs exceed a ceiling of 100% of total direct
        costs excluding equipment and subcontract/consortium costs except for
        the first $25,000 per subcontract/consortium per project period. 
	 	 	 
	 	(2) 	The Government is not obligated to pay any
        additional amount should the final indirect cost rates exceed these negotiated
        ceiling rates. In the event that the final indirect cost rates are less
        than these negotiated ceiling rates, the Government’s obligation shall
        be reduced to conform to the lower rate. 
	 	 	 
	 	 	Any costs over and above this cost ceiling
        shall not be reimbursed under this contract or any other Government contract,
        grant, or cooperative agreement. 
	 	 	 
	 	(3) 	The Contractor shall complete all work in
        accordance with the Statement of Work, terms and conditions of this contract. 
	 	 	 
	e.	Contract Milestones
	 	 
	 	The Contractor shall
        complete all work in accordance with the Statement of Work and the contract
        milestones set forth below. The distribution of the fixed fee shall be
        paid in installments based on the Project Officer’s written certification
        regarding the completion of these milestones as follows: 
	 	 

	 	MILESTONES

      	FIXED
              FEE

      
	 	Preclinical
          Vaccine Production and Screening for Phase I

    	 

    
	1	Finalize safety and immunogenicity
        criteria in small animals for advancing the SOS gp140 trimer
        vaccines into testing in non-human primates.	Non-fundable
          milestone

    
	2	Screen two current SOS gp140
        trimers and control envelope proteins in a series of adjuvants for induction
        of neutralizing antibody in small animals.	$89,816

    
	3	Produce multiple additional
        gp 140 trimers and control envelope proteins in animal-grade form. (Specifically,
        at least 8-10 trimers plus monomer forms.)	$89,816

    
	4	Characterize the antigenicity
        and oligomeric state of the SOS gp140 trimer vaccines.	$89,816

    
	5	Screen additional candidates
        in a series of adjuvants for induction of neutralizing antibody in small
        animals.	$89,816

    
	6	Pass DAIDS-contracted external
        audit of GMP facility.	$89,816

    

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N01-AI-30030

	 	MILESTONES 

    	FIXED
            FEE

    
	7	Select 5 promising
        SOS gp 140 trimer vaccines to test in non-human primates. Design additional
        optimized vaccines for synthesis and testing in small animals if required.	$89,816

    
	8	Finalize safety and immunogenicity
        criteria in non-human primates for advancing the SOS gp 140 trimer vaccines
        into clinical development.	Non-fundable
          milestone

    
	9	Screen the selected SOS gp140
        trimer vaccines for production of neutralizing antibody and protection
        from SHIV challenge in macaques and report results to NIAID Project Officer.	$89,816

    
	10	Select the most promising gp140
        trimer vaccine that meets predetermined safety and immunogenicity criteria
        to advance into clinical development.	$89,816

    
	 	cGMP Vaccine Production and
      IND Preparation for Phase II	 
	11	Finalize the Phase I clinical
        trial concept with the HVTN or other vaccine trials network approved
        by the NIAID Project Officer.	$89,816

    
	12	Develop cGMP manufacturing processes
        for the lead SOS gp 140 trimer vaccine.	$89,816

    
	13	Produce a GMP pilot chemical
        lot of the SOS gp 140 trimer vaccine for IND-enabling preclinical studies.	$89,816

    
	14	Prepare dossier summarizing
        preclinical data and clinical trial design. Schedule Pre-IND meeting
        with CBER/FDA.	$89,816

    
	15	Hold Pre-IND meeting with CBER/FDA.	$89,816

    
	16	Complete IND-enabling formation,
        toxicology, stability and immunogenicity studies.	$89,816

    
	17	Produce clinical lot of the
        SOS gp 140 trimer vaccine	$89,816

    
	18	Finalize
        the Phase I clinical protocol with HVTN or other vaccine trials network
approved by the NIAID Project Officer.
	$89,816

    
	19	File DMF/IND with CBER/FDA 	$89,816

    
	 	Clinical Testing – Phase
      III	 
	20	Initiate
        Phase I clinical testing of the SOS gp l40 trimer vaccine through
the HVTN or other vaccine clinical trials network
approved by the NIAID Project Officer.	Non-fundable
          milestone

    
	21	Complete the Phase I trial.	Non-fundable
          milestone

    
	22	Evaluate the safety and immunogenicity
        data from the Phase I trial and prepare a final study report with recommendations
        for further clinical development with the HVTN or other vaccine trial
        network approved by the Project Officer.	$89,826

    

	 	 	 	 
	f.	Invoices – Cost and Personnel
    Reporting, and Variances from the Negotiated Budget
	 	 	 	 
	 	(1)	 The Contractor agrees to provide a detailed
    breakdown on invoices of the following cost categories: 
	 	 	 	 
	 	 	(a)	Direct Labor – List individuals by name,
    title/position, hourly/annual rate, level of effort, and amount claimed.
	 	 	(b)	Fringe Benefits – Cite rate and amount.

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N01-AI-30030

	 	 	(c)	Materials & Supplies – Include
    detailed breakdown when total amount is over $1,000.
	 	 	(d)	Travel – Identify travelers,
        dates, destination, purpose of trip, and amount. Cite COA, if appropriate.
        List separately, domestic travel, general scientific meeting travel,
    and foreign travel.
	 	 	(e)	Consultant Fees – Identify
    individuals and amounts.
	 	 	(f)	Subcontracts – Attach subcontractor
    invoice(s).
	 	 	(g)	Overhead – Cite rate and
    amount.
	 	 	(h)	Total Cost
	 	 	(i)	Fixed Fee – Cite rate and
    amount
	 	 	(j)	Total CPFF
	 	 	 	 	 
	 	 	Monthly invoices
          must include the cumulative total expenses to date, adjusted (as applicable)
          to show any amounts suspended by the Government.
	 	 	 	 	 
	 	(2) 	The Contractor agrees to
        immediately notify the contracting officer in writing if there is an
        anticipated overrun (any amount) or unexpended balance (greater than
        10 percent) of the amount allotted to the contract, and the reasons for
        the variance. Also refer to the requirements of the Limitation of Funds
    and Limitation of Cost Clauses in the contract. 
	 	 	 	 	 
	g.	GLP/GMP
    Compliance
	 	 	 	 	 
	 	The
          Contractor will be audited for GMP, GLP and QC/QA capabilities within
          four months
          of contract award. Noted deficiencies shall be corrected
          (or addressed) within six months after issuance of the audit report.

    
	 	 	 	 	 
	 	SECTION C – DESCRIPTION/SPECIFICATIONS/WORK
    STATEMENT
	 	 	 	 	 
	 	ARTICLE C.1. STATEMENT OF WORK
	 	 	 	 	 
	 	a.	Independently
          and not as an agent of the Government, the Contractor shall furnish
          all the necessary services, qualified personnel,
          material, equipment, and facilities, not otherwise provided by the
          Government as needed to perform the Statement of Work, SECTION J,
          ATTACHMENT 1, dated September 26, 2003, attached hereto and made a
    part of this contract.

    
	 	 	 	 	 
	 	ARTICLE C.2. REPORTING REQUIREMENTS
	 	 	 	 	 
	 	The Contractor is required to
        formally report progress once per year, through submission of a written
        Technical Report, and once by holding a formal Site Visit review to be
        attended by appropriate NIAID contract staff and program officials, and
        the External Advisory Committee of the Team. The Contractor is also required
        to submit Goals and Milestones Achievement Reports during the contract
    period at appropriate times. Distribution of written reports is
    listed in Article F.1.
	 	 	 	 	 
	 	(1)	 Goals and Milestones
          Achievement Reports. Since the payment of contract fee portions will be tied to the
        accomplishment of negotiated, predetermined goals and milestones, the
        Contractor will submit Goals and Milestones Achievement Reports during
        the contract period as appropriate. The original shall be submitted to
        the Contracting Officer, and two (2) copies (one hard copy and a copy
        in a digital medium) to the Project Officer. Each report must consist
    of: 
	 	 	 	 	 
	 	 	1. 	A cover page 
	 	 	 	 	 
	 	 	2.	 Reports shall include but
    not be limited to the following: 
	 	 	 	 	 
	 	 	 	Section A – An introduction
    covering the goal or milestone 
	 	 	 	 	 
	 	 	 	Section B – A description
        of the results. Description shall include pertinent data and/or figures
        in sufficient detail to explain any significant results from analysis
        and scientific evaluation of data accumulated to date under the goal
        or milestone. When appropriate this report should detail specific requests
    and approvals for the conduct of human trials. 

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	 	(2) 	Clinical Trials Protocol(s).
        NIAID has a responsibility to ensure that mechanisms and procedures are
        in
        place
        to protect the safety of participants in NIAID-supported studies. Therefore,
        as described in the NIAID Clinical Terms of Award and Guidance (http://www.niaid.nih.gov/ncn/clinical/default_human.htm),
        the Contractor shall develop a protocol for each clinical trial and submit
        it for approval by the NIAID Prevention Science Review Committee (PSRC).
        Protocols should include a description of the research design and protocol
        development including definition of objectives and approaches, planning,
        implementation, participant recruitment and follow-up, data collection,
        quality control, data and safety monitoring, final data analysis and
        interpretation, and publication of results. Final approval of this protocol
        must take place prior to participant enrollment. [For trials to be conducted
        through the DAIDS-sponsored HVTN, the protocol should be developed in
    conjunction with the HVTN.] 
	 	 	 	 	 
	 	(3) 	Annual Technical Report.
        By the fifteenth working day of the twelfth month of each Contract year,
        the Contractor
        shall submit Annual Technical Progress Reports as described below. The
        original shall be submitted to the Contracting Officer, and two (2) copies
        (one hard copy and one copy in a digital medium) to the Project Officer.
    The report should be factual and concise and consist of the following: 
	 	 	 	 	 
	 	 	1.	 A cover page 
	 	 	 	 	 
	 	 	2.	 Reports shall include but not be limited
    to the following: 
	 	 	 	 	 
	 	 	 	 	Section A – An introduction covering
    the purpose and scope of the contract effort 
	 	 	 	 	 
	 	 	 	 	Section B – A description of overall
        progress plus a separate description for each task or other logical segment
        of work on which effort was expended during the reporting period. The
        description shall include pertinent data and/or figures in sufficient
        detail to explain any significant results from analysis and scientific
        evaluation of data accumulated to date under the project. Special emphasis
        shall be placed on goals or milestones that were reached, or problems
        that were encountered that prevented reaching a scheduled goal or milestone
        during the reporting period and how those problems were/will be addressed,
    and requests and approvals to conduct human trials. 
	 	 	 	 	 
	 	 	 	 	Section C – A summary of the proposed
        goals and milestones for the duration of the Contract, including any
    proposed revisions based on results generated to date 
	 	 	 	 	 
	 	 	(4) 	Annual Site Visit Review and
          Report.
        At the middle (6 month mark) of each contract year, the Contractor shall
        host, for NIAID contract and program staff and their External Advisory
        Board, a site visit review. The Contractor’s Principal Investigator and
        all co-investigators shall attend this meeting. An update and summary
        of results generated on each sub-project shall be presented by the co-investigator
        and/or other pertinent staff. These presentations shall include summaries
        of all goals or milestones reached during the review period and include
        a description of all problems encountered that will impact the achievement
        of particular goals and milestones as outlined in the Contractor’s research
        plan. The Principal Investigator, co-investigator and staff representing
        each project and sub-project shall describe goals and milestones and
        development objectives for the coming year. Additionally, application
        of the policies and procedures for monitoring the direction of specific
        projects shall be presented. For Contractors with foreign subcontracts,
        this annual site visit will also report details about approvals for manufacturing
        or testing that have been obtained from both the U.S. and foreign governments.
        A report of the plan for, and results of, this site visit shall be prepared
        by the Contractor and submitted to the Project Officer (in hard copy
    and digital medium) and the Contracting Officer (original hard copy). 
	 	 	 	 	 
	 	 	(5)	 Final Technical Report. The Contractor
        shall submit the final report documents, two (2) copies (one hard copy
        and one copy in a digital medium) to the Project Officer, and the original
        to the Contracting Officer, which shall summarize the results of the
        entire contract work for the complete performance period, and shall include
        the specifications of the optimized AIDS vaccine product developed during
        the course of this Contract. These specifications shall include: 1) the
        identity of the vaccine strain or strains in the final product, 2) a
        detailed description of the manipulations used in the vaccine design,
        3) a detailed description of all processes used to expand, attenuate,
        inactivate, or purify the final vaccine product, 4) a detailed description
        of any adjuvants or other potentiating agents used in the delivery of
    the final optimized product, 5) a detailed description of the 

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suggested immunization
    schedule to be used for optimal reactivity in humans, and 6) evidence that
    the vaccine product can
  be manufactured under GMP/GLP conditions for use in human vaccine trials. In
  addition, the Contractor shall indicate whether any INDs were filed in relation
  to vaccine products developed during the course of the Contract, and provide
  a description of the IND and the results of the filings. For Contractors with
  foreign subcontracts, this report shall include details concerning approvals
  for manufacturing or testing that have been obtained for or by the foreign
  subcontractors. The final report shall be submitted by the completion date
  of the Contract.

ARTICLE C.3. INVENTION REPORTING
      REQUIREMENT 

All reports and documentation required
    by FAR Clause 52.227-11 including, but not limited to, the invention disclosure
    report, the confirmatory license, and the government support certification,
    shall be directed to the Extramural Inventions and Technology Resources Branch,
    OPERA, NIH, 6705 Rockledge Drive, Room 1040 A, MSC 7980, Bethesda, Maryland
    20892-7980 (Telephone: 301-435-1986). In addition, one copy of an annual
    utilization report, and a copy of the final invention statement, shall be
    submitted to the Contracting Officer. The final invention statement (see
    FAR 27.303(a)(2)(ii)) shall be submitted to the Contracting Officer within
    90 days after the expiration date of the contract to the following address: 

Contracting Officer 

  National Institutes of Health 

  National Institute of Allergy and Infectious Diseases, CMB

  6700-B Rockledge Drive, Room 2230 

  Bethesda, Maryland 20892-7612

If no invention is disclosed or no
    activity has occurred on a previously disclosed invention during the applicable
    reporting period, a negative report shall be submitted to the Contracting
    Officer at the address listed above. 

To assist Contractors in complying
    with invention reporting requirements of the clause, the NIH has developed “Interagency
    Edison,” an electronic invention reporting system. Use of Interagency Edison
    is encouraged as it streamlines the reporting process and greatly reduces
    paperwork. Access to the system is through a secure interactive Web site
    to ensure that all information submitted is protected. Interagency Edison
    and information relating to the capabilities of the system can be obtained
    from the Web (http://www.iedison.gov) or by contacting the Extramural Inventions
    and Technology Resources Branch, OPERA, NIH. 

SECTION D – PACKAGING, MARKING
      AND SHIPPING 

All deliverables required under this
    contract shall be packaged, marked and shipped in accordance with Government
    specifications. At a minimum, all deliverables shall be marked with the contract
    number and contractor name. The Contractor shall guarantee that all required
    materials shall be delivered in immediate usable and acceptable condition. 

SECTION E – INSPECTION AND
      ACCEPTANCE 

	 	a.  	The
          Contracting Officer or the duly authorized representative will perform inspection and acceptance
          of materials and services to be provided.

    
	 	 	 
	 	b.	For
          the purpose of this SECTION, the Project Officer is the authorized representative of the Contracting
    Officer.

    
	 	 	 
	 	c.	Inspection
          and acceptance will be performed at the address listed in Article G.1.

    
	 	 	 
	 	 	Acceptance may be presumed unless otherwise
        indicated in writing by the Contracting Officer or the duly authorized
    representative within 30 days of receipt. 

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	d. 	This contract incorporates the following
        clause by reference, with the same force and effect as if it were given
        in full text. Upon request, the Contracting Officer will make its full
    text available.
	 	 
	 	FAR Clause No. 52.246-9, INSPECTION OF RESEARCH
    AND DEVELOPMENT (SHORT FORM) (APRIL 1984).

SECTION F – DELIVERIES OR
      PERFORMANCE 

ARTICLE F.1. DELIVERIES 

Satisfactory performance of the final
    contract shall be deemed to occur upon performance of the work described
    in Article C.1. and upon delivery and acceptance by the Contracting Officer,
    or the duly authorized representative, of the following items in accordance
    with the stated delivery schedule: 

	a.	The items specified below as described in
        SECTION C, ARTICLE C.2. will be required to be delivered F.O.B. Destination
        as set forth in FAR 52.247-35, F.O.B. DESTINATION, WITHIN CONSIGNEES
        PREMISES (APRIL 1984), and in accordance
    with and by the dates specified below:
	 	 

	Item	Description	Delivery Schedule
	1	  Goals and Milestones Achievement
        Report	  Quarterly after Award
	2	  Clinical Trials Protocol(s)	  As required by the Project Officer
	3	  Annual Technical Report	  15th day of the twelfth month
        of each Contract Year
	4	  Annual Site Visit Review	  6th month of each Contract Year
	5	  Final Technical Report	  On or before Contract Expiration

 

	b.	The above items shall be addressed and delivered
    to:
	 	 

	Addressee	Deliverable Item	Quantity
	 Contracting
          Officer

  CMB, NIAID, NIH

  Room 2230, MSC 7612

  6700-B Rockledge Drive

  Bethesda, MD 20892-7612
	 Goals
          and Milestones Achievement

  Report

  Clinical Trials Protocol(s)

  Annual Technical Report

  Annual Site Visit Review

  Final Technical Report
	—

        —

        —

        1 copy

        1 copy

        1 copy

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	Addressee	Deliverable Item	Quantity
	 Project
          Officer

  Vaccine & Prevention

  Research Program

  Division of AIDS,

  NIAID, NIH

  Room 4108, MSC 7628

  6700-B Rockledge Drive

  Bethesda, MD 20892-7628
	 Goals
          and Milestones Achievement

  Report

  Clinical Trials Protocol(s)

  Annual Technical Report

  Annual Site Visit Review

  Final Technical Report
	1 copy*

        1 copy*

        1 copy*

        1 copy*

        1 copy*

* Plus one copy on 3.5 inch, high
    density computer diskette or other digital medium approved by the Project
    Officer. 

ARTICLE F.2. CLAUSES INCORPORATED
      BY REFERENCE, FAR 52.252-2 (FEBRUARY 1998) 

This contract incorporates the following
    clause by reference, with the same force and effect as if it were given in
    full text. Upon request, the Contracting Officer will make its full text
    available. Also, the full text of a clause may be accessed electronically
    at this address: http://www.arnet.gov/far/.

FEDERAL ACQUISITION REGULATION
      (48 CFR CHAPTER 1) CLAUSE:

52.242-15, Stop Work Order (AUGUST
    1989) with ALTERNATE I (APRIL 1984). 

SECTION G – CONTRACT ADMINISTRATION
      DATA 

ARTICLE G.l. PROJECT OFFICER

The following Project Officer will
    represent the Government for the purpose of this contract: 

	 	James Bradac, Ph.D. 

Medical Officer, Preclinical Research & Development Branch 

Vaccine & Prevention Research Program 

Division of AIDS, NIAID, NIH

Room 4102, MSC 7628

6700-B Rockledge Drive 

Bethesda, MD 20892-7628 

Phone: (301) 435-3754 

Fax: (301) 402-0122

Email: jbradac@niaid.nih.gov

The Project Officer is responsible
    for: (1) monitoring the Contractor’s technical progress, including the surveillance
    and assessment of performance and recommending to the Contracting Officer
    changes in requirements; (2) interpreting the Statement of Work and any other
    technical performance requirements; (3) performing technical evaluation as
    required; (4) performing technical inspections and acceptances required by
    this contract; and (5) assisting in the resolution of technical problems
    encountered during performance. 

The Contracting Officer is the only
    person with authority to act as agent of the Government under this contract.
    Only the Contracting Officer has authority to: (1) direct or negotiate any
    changes in the Statement of Work; (2) modify or extend the period of performance;
    (3) change the delivery schedule; (4) authorize reimbursement to the Contractor
    any costs incurred during the performance of this contract; or (5) otherwise
    change any terms and conditions of this contract. 

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The Contracting Officer hereby delegates
    the Project Officer as the Contracting Officer’s authorized representative
    responsible for signing software license agreements issued as a result of
    this contract. 

The Government may unilaterally change
    its Project Officer designation. 

ARTICLE G.2. KEY PERSONNEL 

Pursuant to the Key Personnel clause
    incorporated in this contract, the following individuals are considered to
    be essential to the work being performed hereunder: 

	 	Name	                    Title

	 	 	 
	 	Paul J. Maddon, M.D., Ph.D.	 Principal Investigator, Progenics
    Pharmaceuticals, Inc.
	 	William C. Olson, Ph.D.	 Co-PI,  Progenics
    Pharmaceuticals, Inc.
	 	John P. Moore, Ph.D.	 Investigator, Weill Medical College
    of Cornell University (Subcontractor)
	 	Preston A. Marx, Ph.D.	 Investigator, Tulane Regional Primate
    Research Center (Subcontractor)

ARTICLE G.3. INVOICE SUBMISSION/CONTRACT
      FINANCING REQUEST AND CONTRACT FINANCIAL REPORT 

	a. 	Invoice/Financing Request Instructions
        and Contract Financial Reporting for NIH Cost-Reimbursement Type Contracts
        NIH(RC)-4 are attached and made part of this contract. The instructions
        and the following directions for the submission of invoices/financing
        request must be followed to meet the requirements of a “proper” payment
    request pursuant to FAR 32.9.

These instructions also provide for
    the submission of financial and personnel reporting required by HHSAR 342.7002. 

	 	(1)	Invoices/financing requests shall be submitted
    as follows: 
	 	 	 
	 	 	An original and two copies to the following
    designated billing office:

Contracting Officer

Contract Management
    Branch

        National Institute of Allergy and Infectious Diseases, NIH

        Room 2230

        6700-B ROCKLEDGE DRIVE, MSC 7612

      BETHESDA, MD 20892-7612

	 	(2)	Inquiries regarding payment of invoices should
    be directed to the designated billing office, (301) 496-0612.
	 	 	 
	b.	The Contractor shall include the following
        certification on every invoice for reimbursable costs incurred with Fiscal
        Year funds subject to the salary rate limitation provisions as specified
        in ARTICLE H.12. of this contract. For billing purposes, certified invoices
        are required for the billing period during which the applicable Fiscal
        Year funds were initially charged through the final billing period utilizing
    the applicable Fiscal Year funds:
	 	 	 
	 	 	“I hereby certify that the salaries
        charged in this invoice are in compliance with P.L. 108-7 and ARTICLE
    H.12. of the above referenced contract.”

ARTICLE G.4. INDIRECT COST RATES 

In accordance with Federal Acquisition
    Regulation (FAR) (48 CFR Chapter 1) Clause 52.216-7 (d)(2), Allowable Cost
    and Payment incorporated by reference in this contract in Part II, Section
    I, the cognizant Contracting Officer representative responsible for negotiating
    provisional and/or final indirect cost rates is identified as follows: 

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Director, Division of Financial Advisory
    Services

        Office of Acquisition Management
    and Policy

        National Institutes of Health

        6100 Building, Room 6B05

        6100 EXECUTIVE BLVD MSC 7540

        BETHESDA MD 20892-7540

These rates are hereby incorporated
    without further action of the Contracting Officer. 

ARTICLE G.5. GOVERNMENT PROPERTY 

	a.	In addition to the requirements of the clause,
        GOVERNMENT PROPERTY, incorporated in SECTION I of this contract, the
        Contractor shall comply with the provisions of DHHS Publication, Contractor’s
        Guide for Control of Government Property, 1990, which is incorporated
        into this contract by reference. Among other issues, this publication
        provides a summary of the Contractor’s responsibilities regarding purchasing
        authorizations and inventory and reporting requirements under the contract.
        A copy of this publication is available upon request to the Contracts
    Property Administrator. 
	 	 
	 	Requests for information regarding property
    under this contract should be directed to the following office:

Division of Personal Property Services,
NIH

6011 Building, Suite 637

6011 EXECUTIVE BLVD MSC 7670

BETHESDA MD 20852-7670

(301) 496-6466

ARTICLE G.6. POST AWARD EVALUATION
    OF CONTRACTOR PERFORMANCE

	a.	Contractor Performance Evaluations
	 	 
	 	Interim and final evaluations of contractor
        performance will be prepared on this contract in accordance with FAR
        42.15. The final performance evaluation will be prepared at the time
        of completion of work. In addition to the final evaluation, interim evaluations
        will be prepared annually to coincide with the anniversary date of the
    contract.
	 	 
	 	Interim and final evaluations will be provided
        to the Contractor as soon as practicable after completion of the evaluation.
        The Contractor will be permitted thirty days to review the document and
        to submit additional information or a rebutting statement. If agreement
        cannot be reached between the parties, the matter will be referred to
        an individual one level above the Contracting Officer, whose decision
    will be final.
	 	 
	 	Copies of the evaluations, contractor responses,
        and review comments, if any, will be retained as part of the contract
    file, and may be used to support future award decisions.
	 	 
	b.	Electronic Access to Contractor Performance
    Evaluations
	 	 
	 	Contractors that have Internet capability
        may access evaluations through a secure
        Web site for review and comment by completing the registration
    form that can be obtained at the following address:

http://ocm.od.nih.gov/cdmp/cps_contractor.htm

The registration process requires
    the contractor to identify an individual
    that will serve as a primary contact and who will be authorized
    access to the evaluation for review and comment. In addition,
    the contractor will be required to identify an alternate contact
    who will be responsible for notifying the cognizant contracting official
    in the event the primary contact is unavailable to process the evaluation within the required 30-day
    time frame.

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SECTION H – SPECIAL CONTRACT
REQUIREMENTS 

ARTICLE H.1. REIMBURSEMENT OF
      COSTS FOR INDEPENDENT RESEARCH AND DEVELOPMENT PROJECTS 

The primary purpose of the Public
    Health Service (PHS) is to support and advance independent research within
    the scientific community. PHS has established effective, time tested and
    well recognized procedures for stimulating and supporting this independent
    research by selecting from multitudes of applications those research projects
    most worthy of support within the constraints of its appropriations. The
    reimbursement through the indirect cost mechanism of independent research
    and development costs not incidental to product improvement would circumvent
    this competitive process. 

To ensure that all research and development
    projects receive similar and equal consideration, all organizations may compete
    for
    direct funding of independent research and development projects they consider
    worthy of support by submitting those projects to the appropriate Public
    Health Service grant office for review. Since these projects may be submitted
    for direct funding, the Contractor agrees that no costs for any independent
    research and development project, including all applicable indirect costs,
    will be claimed under this contract. 

ARTICLE H.2. RESTRICTION FROM
      USE OF HUMAN SUBJECTS 

NOTICE: UNDER GOVERNING REGULATIONS,
      FEDERAL FUNDS ADMINISTERED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
      SHALL NOT BE EXPENDED FOR RESEARCH INVOLVING HUMAN SUBJECTS, AND INDIVIDUALS
      SHALL NOT BE ENROLLED IN SUCH RESEARCH, WITHOUT PRIOR APPROVAL BY THE OFFICE
      FOR HUMAN RESEARCH PROTECTIONS (OHRP) OF AN ASSURANCE TO COMPLY WITH THE
      REQUIREMENTS OF 45 CFR 46 TO PROTECT HUMAN RESEARCH SUBJECTS. THIS RESTRICTION
      APPLIES TO ALL COLLABORATING SITES WITHOUT OHRP-APPROVED ASSURANCES, WHETHER
      DOMESTIC OR FOREIGN, AND COMPLIANCE MUST BE ENSURED BY THE AWARDEE. 

ARTICLE H.3. REQUIRED EDUCATION
      IN THE PROTECTION OF HUMAN RESEARCH PARTICIPANTS 

NIH policy requires education on
    the protection of human subject participants for all investigators receiving
    NIH contract awards for research involving human subjects. For a complete
    description of the NIH Policy announcement on required education in the protection
    of human subject participants, the contractor should access the NIH Guide
    for Grants and Contracts Announcement dated June 5, 2000 at the following
    website: http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-039.html.
    The information below is a summary of the NIH Policy Announcement: 

The contractor shall maintain the
    following information: (1) a list of the names and titles of the principal
    investigator and any other individuals working under the contract who are
    responsible for the design and/or conduct of the research; (2) the title
    of the education program(s) in the protection of human subjects that has
    been completed for each named personnel and; (3) a one sentence description
    of the educational program(s) listed in (2) above. This requirement extends
    to investigators and all individuals responsible for the design and/or conduct
    of the research who are working as subcontractors or consultants under the
    contract. 

Prior to any substitution of the
    Principal Investigator or any other individuals responsible for the design
    and/or conduct of the research under the contract, the contractor shall provide
    the following written information to the Contracting Officer: the title of
    the education program and a one sentence description of the program that
    has been completed by the replacement. 

ARTICLE H.4. DATA AND SAFETY MONITORING
      IN CLINICAL TRIALS 

The Contractor is directed to the
    full text of the NIH Policy regarding Data and Safety Monitoring and Reporting
    of Adverse Events, which may be found at the following web sites: 

http://grants.nih.gov/grants/guide/notice-files/not98-084.htm1

http://grants.nih.gov/grants/guide/notice-files/not99-107.html

http://grants.nih.gov/grants/guide/notice-files/NOT-OD-00-038.html

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The Contractor must comply with the
    NIH Policy cited in these NIH Announcements, the NIAID Clinical Terms of
    Award (http://www.niaid.nih.gov/ncn/clinical/ default_human.htm),and any
    other data and safety monitoring requirements found elsewhere in this contract.

Data and Safety Monitoring shall
    be performed in accordance with the Data and Safety Monitoring Plan. 

The Data and Safety Monitoring Board
    and Plan shall be established and approved prior to beginning the conduct
    of the clinical trial. 

ARTICLE H.5. HUMAN MATERIALS 

The acquisition and supply of all
    human specimen material (including fetal material) used under this contract
    shall be obtained by the Contractor in full compliance with applicable State
    and Local laws and the provisions of the Uniform Anatomical Gift Act in the
    United States, and no undue inducements, monetary or otherwise, will be offered
    to any person to influence their donation of human material.

ARTICLE H.6. CONTINUED BAN ON
      FUNDING OF HUMAN EMBRYO RESEARCH 

	a.	Pursuant to Public Law(s) cited
        in paragraph b. , below, NIH is prohibited from using appropriated funds
        to support human embryo research. Contract funds may not be used for
        (1) the creation of a human embryo or embryos for research proposes;
        or (2) research in which a human embryo or embryos are destroyed, discarded,
        or knowingly subjected to risk of injury or death greater than that allowed
        for research on fetuses in utero under 45 CFR 46.208(a)(2) and Section
        498(b) of the Public Health Service Act (42 U.S.C. 289g(b)). The term “human
        embryo or embryos” includes any organism, not protected as a human
        subject under 45 CFR 46 as of the date of the enactment of this Act,
        that is derived by fertilization, parthenogenesis, cloning, or any other
    means from one or more human gametes or human diploid cells.
	 	 	 	 
	 	Additionally,
        in accordance with a March 4, 1997 Presidential Memorandum,
    Federal funds may not be used for cloning of human beings.	 	 
	 	 	 	 
	b.	Public Law and Section No.	Fiscal Year	Period Covered
	 	 	 	 
	 	P.L. 108-7, Division G, Title V-        	2003 	 10/1/02 – 9/30/03
	 	General Provisions, Section 510	 	 
	 	 	 	 
	ARTICLE H.7. NEEDLE EXCHANGE 	 	 
	 	 	 	 
	a.	Pursuant
    to Public Law(s) cited in paragraph b., below, contract funds shall not be
        used to carry out any program of distributing sterile needles or syringes
        for the hypodermic
    injection of any illegal drug.
	 	 	 	 
	b.	Public Law and Section No.          	Fiscal Year	Period Covered
	 	 	 	 
	 	P.L. 108-7, Division G, Title V-          	2003	10/1/02 – 9/30/03
	 	General Provisions, Section 505	 	 

ARTICLE H.8. PRIVACY ACT 

This procurement action requires
    the Contractor to do one or more of the following: design, develop, or operate
    a system of records on individuals to accomplish an agency function in accordance
    with the Privacy Act of 1974, Public Law 93-579, December 31, 1974 (5 USC
    552a) and applicable agency regulations. Violation of the Act may involve
    the imposition of criminal penalties.

The Privacy Act System of Records
    applicable to this project is Number 09-25-0200. This document may be accessed
    on the Internet at the following URL: http://oma.od.nih.gov/ms/privacy/pa-files/0200.htm.

 

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ARTICLE H.9. INTRODUCTION OF RODENTS
      AND RODENT PRODUCTS 

No rodent or rodent product shall
    be delivered into the NIH, NCI environment (NIH) directly, or through collaborative
    research or holding facilities under contract to NCI except by permit. Direct
    shipments to NIH from a commercial colony will be considered exempt. Non-exempt
    sources must be approved by permit issued through the National Center for
    Research Resources (NCRR). The permit must be obtained by the Contractor
    prior to the shipment to NIH of the rodents and/or rodent products. The Contractor
    must be sure that this permit exists and is current before transferring rodents
    or rodent products into the NIH, NCI environment. Refusal or negligence to
    do so will be considered a material breach of contract and may be treated
    as any other such material breach. Applications for permits should be submitted
    not less than 30 days prior to shipping date to: NIH Veterinary Resources
    Branch (VRP), National Center for Research Resources (NCRR), Scientific Services
    Branch, Laboratory Sciences Section, Building 28A, Room 111, 28 LIBRARY DR
    MSC 5210, BETHESDA MD 20892-5210,(301)496-2527. 

ARTICLE H.10. ANIMAL WELFARE 

All research involving live, vertebrate
    animals shall be conducted in accordance with the Public Health Service Policy
    on Humane Care and Use of Laboratory Animals. This policy may be accessed
    at http:/grants1.nih.gov/grants/olaw/references/phspol.htm

ARTICLE H.11. RESTRICTION FROM
      USE OF LIVE VERTEBRATE ANIMALS

UNDER GOVERNING POLICY, FEDERAL
      FUNDS ADMINISTERED BY THE PUBLIC HEALTH SERVICE (PHS) SHALL NOT BE EXPENDED
      FOR RESEARCH INVOLVING LIVE VERTEBRATE ANIMALS WITHOUT PRIOR APPROVAL BY
      THE OFFICE FOR LABORATORY ANIMAL WELFARE (OLAW), OF AN ASSURANCE TO COMPLY
      WITH THE PHS POLICY ON HUMANE CARE AND USE OF LABORATORY ANIMALS. THIS
      RESTRICTION APPLIES TO ALL PERFORMANCE SITES WITHOUT OLAW-APPROVED ASSURANCES,
      WHETHER DOMESTIC OR FOREIGN.

ARTICLE H.12. SALARY RATE LIMITATION
      LEGISLATION PROVISIONS 

	a. 	Pursuant to Public Law(s) cited
        in paragraph b., below, no NIH Fiscal Year funds may be used to pay the
        direct salary of an individual through this contract at a rate in excess
        of applicable amount shown for the fiscal year covered. Direct salary
        is exclusive of fringe benefits, overhead, and general and administrative
        expenses (also referred to as “indirect cost” or “facilities
        and administrative (F&A) costs”). Direct salary has the same
        meaning as the term “institutional base salary.” An individual's
        direct salary (or institutional base salary) is the annual compensation
        that the contractor pays for an individual's appointment whether that
        individual's time is spent on research, teaching, patient care or other
        activities. Direct salary (or institutional base salary) excludes any
        income that an individual may be permitted to earn outside of duties
        to the contractor. The per year salary rate limit also applies to individuals
        proposed under subcontracts. It does not apply to fees paid to consultants.
        If this is a multiple year contract, it may be subject to unilateral
        modifications by the Government if an individual's salary rate exceeds
    any salary rate ceiling established in future HHS appropriation acts.
	 	 	 	 
	b. 	Public Law
    No.	Fiscal Year	Dollar Amount of

      Salary Limitation*
	 	P.L. 108-7, Division G, Title II-    	 2003 	 Executive Level I
	 	General Provisions, Section 204	 	 
	 	 	 	 
	c.	Direct salaries which will be paid with FY-03
        funds are limited to the Executive Level I rate which was in effect on
    the date(s) the expense was incurred.

*For contract expenditures using
    FY-03 funds, the period 10/1/02 – 12/31/02 the Executive Level rate
    is $166,700. Effective 1/1/03, for contract expenditures using FY-03 funds,
    the Executive
    Level I rate is increased to $171,900 and will remain at that level until
    such time as it is determined to raise the Executive Schedule annual rates.
    See the web site listed below for Executive Schedule rates of pay.

LINK to EXECUTIVE LEVEL SALARIES:
    http://www.opm.gov/oca/PAYRATES/index.htm

(Click on “Executive Schedule” for
    the current Fiscal Year’s salary rate or scroll down to the “General
    Schedule Salary Tables from Previous Years” to locate the Executive
    Level salary rates
from previous years.)

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ARTICLE H.13. PUBLICATION AND
      PUBLICITY 

The contractor shall acknowledge
    the support of the National Institutes of Health whenever publicizing the
    work under this contract in any media by including an acknowledgment substantially
    as follows: 

“This project has been funded in
    whole or in part with Federal funds from the National Institute of Allergy
    and Infectious Diseases, National Institutes of Health, Department of Health
    and Human Services, under Contract No. N0l-AI-30030.”

ARTICLE H.14. PRESS RELEASES 

	a.	 Pursuant to Public Law(s)
        cited in paragraph b., below, the contractor shall clearly state, when
        issuing statements, press releases, requests for proposals, bid solicitations
        and other documents describing projects or programs funded in whole or
        in part with Federal money: (1) the percentage of the total costs of
        the program or project which will be financed with Federal money; (2)
        the dollar amount of Federal funds for the project or program; and (3)
        the percentage and dollar amount of the total costs of the project or
    program that will be financed by nongovernmental sources.
	 	 	 	 
	b.	Public Law and Section No.	Fiscal Year	Period Covered
	 	 	 	 
	 	P.L. 108-7, Division G, Title V-

      General Provisions, Section 507      

    	2003	10/1/02 – 9/30/03

ARTICLE H.15. REPORTING MATTERS
      INVOLVING FRAUD, WASTE AND ABUSE 

Anyone who becomes aware of the existence
    or apparent existence of fraud, waste and abuse in NIH funded programs is
    encouraged to report such matters to the HHS Inspector General’s Office in
    writing or on the Inspector General’s Hotline. The toll free number is 1-800-HHS-TIPS
    (1-800-447-8477). All telephone calls will be handled confidentially. The
    email address is Htips@os.dhhs.gov and the mailing address is: 

Office of Inspector General

  Department
    of Health and Human Services 

TIPS HOTLINE 

P.O. Box 23489 Washington, D.C. 20026

ARTICLE H.16. ANTI-LOBBYING 

	a.	Pursuant to Public Law(s) cited
        in paragraph c., below, contract funds shall not be used, other than
        for normal and recognized executive-legislative relationships, for publicity
        or propaganda purposes, for the preparation, distribution, or use of
        any kit, pamphlet, booklet, publication, radio, television, or video
        presentation designed to support or defeat legislation pending before
        the Congress or any State legislature, except in presentation to the Congress
    or any State legislature itself.
	 	 	 	 
	b.	Contract funds shall not be used
        to pay salary or expenses of the contractor or any agent acting for the
        contractor, related to any activity designed to influence legislation
    or appropriations pending before the Congress or any State legislature.
	 	 	 	 
	c.	Public Law and Section No.	Fiscal Year	Period
Covered
	 	 	 	 
	 	for a., above: P.L. 108-7,  Division
    G, Title V-

         General Provisions, Section 503a    	2003	 10/1/02 – 9/30/03
	 	for b., above: P.L. 108-7, Division
    G, Title V,

         General Provisions, Section 503b    	 2003	   10/1/02 – 9/30/03

 

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ARTICLE H.17. OBTAINING AND DISSEMINATING
      BIOMEDICAL RESEARCH RESOURCES 

Unique research resources arising
    from NIH-funded research are to be shared with the scientific research community.
    NIH provides guidance, entitled, “Sharing Biomedical Research Resources:
    Principles and Guidelines for Recipients of NIH Research Grants and Contracts,”  (Federal Register Notice, December 23, 1999 [64 FR 72090]), concerning the
    appropriate
    terms for disseminating and acquiring these research resources. This guidance,
    found at: http://ott.od.nih.gov/NewPages/64FR72090.pdf. is intended to help
    contractors ensure that the conditions they impose and accept on the transfer
    of research tools will facilitate further biomedical research, consistent
    with the requirements of the Bayh-Dole Act and NIH funding policy. 

Note: For the purposes of this Article,
    the terms, “research tools,” “research materials,” and “research
    resources” are
    used interchangeably and have the same meaning.

ARTICLE H.18. PROHIBITION ON CONTRACTOR
      INVOLVEMENT WITH TERRORISM ACTIVITIES 

The Contractor acknowledges that
    U.S. Executive Orders and Laws, including but not limited to E.O. 13224 and
    P.L. 107-56, prohibit transactions with, and the provision of resources and
    support to, individuals and organizations associated with terrorism. It is
    the legal responsibility of the contractor to ensure compliance with these
    Executive Orders and Laws. This clause must be included in all subcontracts
    issued under this contract. 

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N01-AI-30030

PART II – CONTRACT CLAUSES

SECTION I – CONTRACT CLAUSES 

ARTICLE 1.1. GENERAL CLAUSES FOR
      A COST-REIMBURSEMENT RESEARCH AND DEVELOPMENT CONTRACT – FAR 52.252-2,
      CLAUSES INCORPORATED BY REFERENCE (FEBRUARY 1998) 

This contract incorporates the following
    clauses by reference, with the same force and effect as if they were given
    in full text. Upon request, the Contracting Officer will make their full
    text available. Also, the full text of a clause may be accessed electronically
    at this address: http://www.arnet.gov/far/.

a.      FEDERAL
      ACQUISITION REGULATION (FAR) (48 CFR CHAPTER 1) CLAUSES:

	FAR
                    

      CLAUSE                    

    NO.                    	DATE                              	                    TITLE	 
	 	 	 	 
	52.202-1	Dec 2001	Definitions	 
	 	 	 	 
	52.203-3	Apr 1984	Gratuities (Over $100,000)	 
	 	 	 	 
	52.203-5	Apr 1984	Covenant Against Contingent
        Fees (Over $100,000)	 
	 	 	 	 
	52.203-6	Jul 1995	Restrictions on Subcontractor
        Sales to the Government (Over $100,000)	 
	 	 	 	 
	52.203-7	Jul 1995	Anti-Kickback Procedures (Over
        $100,000)	 
	 	 	 	 
	52.203-8	Jan 1997	Cancellation, Rescission, and
        Recovery of Funds for Illegal or Improper Activity (Over $100,000)	 
	 	 	 	 
	52.203-10	Jan 1997	Price or Fee Adjustment for
        Illegal or Improper Activity (Over $100,000)	 
	 	 	 	 
	52.203-12	Jun 2003	Limitation on Payments to Influence
        Certain Federal Transactions (Over $100,000)	 
	 	 	 	 
	52.204-4	Aug 2000	Printed or Copied Double-Sided
        on Recycled Paper (Over $100,000)	 
	 	 	 	 
	52.209-6	Jul 1995	Protecting the Government’s
        Interests When Subcontracting With Contractors Debarred, Suspended, or
        Proposed for Debarment (Over $25,000)	 
	 	 	 	 
	52.215-2	Jun 1999	Audit and Records – Negotiation
        (Over $100,000)	 
	 	 	 	 
	52.215-8	Oct 1997	Order of Precedence – Uniform
        Contract Format	 
	 	 	 	 
	52.215-10	Oct 1997	Price Reduction for Defective
        Cost or Pricing Data	 
	 	 	 	 
	52.215-12	Oct 1997	Subcontractor Cost or Pricing
        Data (Over $500,000)	 
	 	 	 	 
	52.215-14	Oct 1997	Integrity of Unit Prices (Over
        $100,000)	 
	 	 	 	 
	52.215-15	Dec 1998	Pension Adjustments and Asset
        Reversions	 
	 	 	 	 
	52.215-18	Oct 1997	Reversion or Adjustment of Plans
        for Post-Retirement Benefits (PRB) other than Pensions	 
	 	 	 	 
	52.215-19	Oct 1997	Notification of Ownership Changes	 

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	52.215-21	Oct 1997	Requirement for
        Cost or Pricing Data or Information Other Than Cost or Pricing Data – Modifications
	 	 	 
	52.216-7	Dec 2002	Allowable Cost and Payment
	 	 	 
	52.216-8	Mar 1997	Fixed Fee
	 	 	 
	52.219-8	Oct 2000	Utilization of Small Business
        Concerns (Over $100,000)
	 	 	 
	52.219-9	Jan 2002	Small Business Subcontracting
        Plan (Over $500,000)
	 	 	 
	52.219-16	Jan 1999	Liquidated Damages – Subcontracting
        Plan (Over $500,000)
	 	 	 
	52.222-2	Jul 1990	Payment for Overtime Premium
        (Over $100,000) (Note: The dollar amount in paragraph (a) of this clause
        is $0 unless otherwise specified in the contract.)
	 	 	 
	52.222-3	Jun 2003	Convict Labor
	 	 	 
	52.222-26	Apr 2002	Equal Opportunity
	 	 	 
	52.222-35	Dec 2001	Equal Opportunity for Special
        Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans
	 	 	 
	52.222-36	Jun 1998	Affirmative Action for Workers
        with Disabilities
	 	 	 
	52.222-37	Dec 2001	Employment Reports on Special
        Disabled Veterans, Veterans of the Vietnam Era, and Other Eligible Veterans
	 	 	 
	52.223-6	May 2001	Drug-Free Workplace
	 	 	 
	52.223-14	Jun 2003	Toxic Chemical Release Reporting
	 	 	 
	52.225-1	Jun 2003	Buy American Act – Supplies
	 	 	 
	52.225-13	Jun 2003	Restrictions on Certain Foreign
        Purchases
	 	 	 
	52.227-1	Jul 1995	Authorization and Consent, Alternate
        I (Apr 1984)
	 	 	 
	52.227-2	Aug 1996	Notice and Assistance Regarding
        Patent and Copyright Infringement (over $100,000)
	 	 	 
	52.227-11	Jun 1997	Patent Rights – Retention
        by the Contractor (Short Form) (Note: In accordance with FAR 27.303(a)(2),
        paragraph (f) is modified to include the requirements in FAR 27.303(a)(2)(i)
        through (iv). The frequency of reporting in (i) is annual.
	 	 	 
	52.227-14	Jun 1987	Rights in Data – General
	 	 	 
	52.232-9	Apr 1984	Limitation on Withholding of
        Payments
	 	 	 
	52.232-17	Jun 1996	Interest (Over $100,000)
	 	 	 
	52.232-20	Apr 1984	Limitation of Cost
	 	 	 
	52.232-23	Jan 1986	Assignment of Claims
	 	 	 
	52.232-25	Feb 2002	Prompt Payment, Alternate I
        (Feb 2002)
	 	 	 
	52.232-34	May 1999	Payment by Electronic Funds
        Transfer–Other Than Central Contractor Registration
	 	 	 

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	52.233-1	Jul 2002	Disputes
	 	 	 
	52.233-3	Aug 1996	Protest After Award, Alternate
        I (Jun 1985)
	 	 	 
	52.242-1	Apr 1984	Notice of Intent to Disallow
        Costs
	 	 	 
	52.242-3	May 2001	Penalties for Unallowable Costs
        (Over $500,000)
	 	 	 
	52.242-4	Jan 1997	Certification of Final Indirect
        Costs
	 	 	 
	52.242-13	Jul 1995	Bankruptcy (Over $100,000)
	 	 	 
	52.243-2	Aug 1987	Changes – Cost Reimbursement,
        Alternate V (Apr 1984)
	 	 	 
	52.244-2	Aug 1998	Subcontracts, Alternate II (Aug
        1998) *If written consent to subcontract is required, the identified
        subcontracts are listed in ARTICLE B, Advance Understandings.
	 	 	 
	52.244-5	Dec 1996	Competition in Subcontracting
        (Over $100,000)
	 	 	 
	52.245-5	Jun 2003	Government Property (Cost-Reimbursement,
        Time and Material, or Labor-Hour Contract)
	 	 	 
	52.246-23	Feb 1997	Limitation of Liability (Over
        $100,000)
	 	 	 
	52.249-6	Sep 1996	Termination (Cost-Reimbursement)
	 	 	 
	52.249-14	Apr 1984	Excusable Delays
	 	 	 
	52.253-1	Jan 1991	Computer Generated Forms
	 	 	 

	b.	DEPARTMENT
        OF HEALTH AND HUMAN SERVICES ACQUISITION REGULATION (HHSAR) (48 CFR CHAPTER
    3) CLAUSES:

	 	 	 
	  HHSAR	 	 
	CLAUSE	 	 
	      NO	DATE	        TITLE
	 	 	 
	352.202-1	Jan 2001	Definitions – with
        Alternate paragraph (h) (Jan 2001)
	 	 	 
	352.216-72	Oct 1990	Additional Cost Principles
	 	 	 
	352.228-7	Dec 1991	Insurance – Liability to
        Third Persons
	 	 	 
	352.232-9	Apr 1984	Withholding of Contract Payments
	 	 	 
	352.233-70	Apr 1984	Litigation and Claims
	 	 	 
	352.242-71	Apr 1984	Final Decisions on Audit Findings
	 	 	 
	352.270-5	Apr 1984	Key Personnel
	 	 	 
	352.270-6	Jul 1991	Publications and Publicity
	 	 	 
	352.270-7	Jan 2001	Paperwork Reduction Act

[End of GENERAL CLAUSES FOR A COST-REIMBURSEMENT
    RESEARCH AND DEVELOPMENT CONTRACT – Rev. 6/2003].

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ARTICLE I.2 AUTHORIZED SUBSTITUTION
      OF CLAUSES 

ARTICLE I.1. of this SECTION is hereby
    modified as follows:

FAR Clause 52.219-9, SMALL BUSINESS
    SUBCONTRACTING PLAN (JANUARY 20021), and FAR Clause 52.219-16, LIQUIDATED
    DAMAGES–SUBCONTRACTING PLAN (JANUARY 1999) are deleted in their entirety.

FAR Clause 52.232-20, LIMITATION
    OF COST, is deleted in its entirety and FAR Clause 52.232-22, LIMITATION
    OF FUNDS (APRIL 1984) is substituted therefor. Note: When this contract is
    fully funded, FAR Clause 52.232-22, LIMITATION OF FUNDS will no longer apply
    and FAR Clause 52.232-20, LIMITATION OF COST will become applicable.

ARTICLE I.3. ADDITIONAL CONTRACT
      CLAUSES 

This contract incorporates the following
    clauses by reference, with the same force and effect, as if they were given
    in full text. Upon request, the Contracting Officer will make their full
    text available.

	a.	FEDERAL
    ACQUISITION REGULATION (FAR) (48 CFR CHAPTER 1) CLAUSES
	 	 	 
	 	(1)	FAR 52.215-17, Waiver of Facilities
    Capital Cost of Money (OCTOBER 1997).
	 	 	 	 
	 	(2)	FAR 52.219-4, Notice of Price
        Evaluation Preference for HUBZone Small Business Concerns (JANUARY 1999).
	 	 	 	 
	 	 	“(c)	Waiver
    of evaluation preference.....
	 	 	 	 
	 	 	 	[      ]     Offeror
    elects to waive the evaluation preference.”
	 	 	 	 
	 	(3)	FAR 52.219-23, Notice of Price Evaluation
    Adjustment for Small Disadvantaged Business Concerns (JUNE 2003).
	 	 	 	 
	 	 	“(b)	Evaluation adjustment. (1) The Contracting
        Officer will evaluate offers by adding a factor of 10% to the price of
    all offers, except–...”
	 	 	 	 
	 	(4)	FAR 52.224-1, Privacy Act Notification
    (APRIL 1984).
	 	 	 	 
	 	(5)	FAR 52.224-2, Privacy Act (APRIL
        1984).
	 	 	 	 
	 	(6)	FAR 52.227-14, Rights in Data – General
    (JUNE 1987).
	 	 	 	 
	 	(7)	FAR 52.242-3, Penalties for
    Unallowable Costs (MAY 2001).
	 	 	 	 
	 	(8)	FAR 52.247-63, Preference for U.S. Flag
    Air Carriers (JUNE 2003).
	 	 	 	 
	b.	DEPARTMENT
    OF HEALTH AND HUMAN SERVICES ACQUISITION REGULATION (HHSAR)(48 CHAPTER 3)
    CLAUSES:
	 	 	 	 
	 	(1)	HHSAR 352.223-70, Safety and Health (JANUARY
    2001). [This clause is provided in full text in SECTION J – ATTACHMENTS.]
	 	 	 	 
	 	(2)	HHSAR 352.270-8, Protection of Human
    Subjects (JANUARY 2001).
	 	 	 	 
	 	 	Note: The Office for Human Research Protections
        (OHRP), Office of the Secretary (OS), Department of Health and Human
        Services (DHHS) is the office responsible for oversight of the Protection
    of Human subjects and
	 	 	 	 

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N01 AI-30030

	 	 	should replace Office for Protection
        from Research Risks (OPRR), National Institutes of Health (NIH) wherever
    it appears in this clause.
	 	 	 	 	 
	 	(3)	HHSAR 352.270-9, Care of Live Vertebrate
    Animals (JANUARY 2001).
	 	 	 	 	 
	c.	NATIONAL
    INSTITUTES OF HEALTH (NIH) RESEARCH CONTRACTING (RC) CLAUSES:
	 	 	 	 	 
	 	The following clauses are attached and made
    a part of this contract:
	 	 	 	 	 
	 	(1)	NIH (RC)-7, Procurement of Certain Equipment
    (APRIL 1984) (OMB Bulletin 81-16).
	 	 	 	 	 
	 	(2)	NIH(RC)-11, Research Patient Care Costs
    (4/1/84).
	 	 	 	 	 
	ARTICLE I.4. ADDITIONAL FAR CONTRACT CLAUSES
    INCLUDED IN FULL TEXT 
	 	 	 	 	 
	This contract incorporates the following
    clauses in full text.
	 	 	 	 	 
	FEDERAL ACQUISITION REGULATION (FAR)(48
    CFR CHAPTER 1) CLAUSES:
	 	 	 	 	 
	a.	FAR Clause
    52.244-6, SUBCONTRACTS FOR COMMERCIAL ITEMS (APRIL 2003)
	 	 	 	 	 
	 	(a)	Definitions. As used in this clause–
	 	 	 	 	 
	 	 	Commercial item, has the meaning contained
    in the clause at 52.202-1, Definitions.
	 	 	 	 	 
	 	 	Subcontract, includes a transfer of commercial
        items between divisions, subsidiaries, or affiliates of the Contractor
    or subcontractor at any tier.
	 	 	 	 	 
	 	(b)	To the maximum extent practicable, the
        Contractor shall incorporate, and require its subcontractors at all tiers
        to incorporate, commercial items or nondevelopmental items as components
    of items to be supplied under this contract.
	 	 	 	 	 
	 	(c)	(1)	The Contractor shall insert the following
    clauses in subcontracts for commercial items:
	 	 	 	 	 
	 	 	 	(i)	52.219-8,
    Utilization of Small Business Concerns (OCT 2000) (15 U.S.C. 637(d)(2) and (3)), in all subcontracts that offer further subcontracting opportunities. If the subcontract (except subcontracts to small business concerns) exceeds $500,000 ($1,000,000 for construction of
any public facility), the subcontractor must include 52.219-8 in lower tier subcontracts that offer subcontracting opportunities.
	 	 	 	 	 
	 	 	 	(ii)	52.222-26,
    Equal Opportunity (APR 2002) (E.O. 11246).
	 	 	 	 	 
	 	 	 	(iii)	52.222-35,
        Equal Opportunity for Special Disabled Veterans, Veterans of the Vietnam
    Era, and Other Eligible Veterans (DEC 2001) (38 U.S.C. 4212(a)).
	 	 	 	 	 
	 	 	 	(iv)	52.222-36,
        Affirmative Action for Workers with Disabilities (JUN 1998) (29 U.S.C.
    793).
	 	 	 	 	 
	 	 	 	(v)	52.247-64,
    Preference for Privately Owned U.S.-Flag Commercial Vessels (APR 2003) (46 U.S.C. Appx 1241 and 10 U.S.C. 2631) (flow down required in accordance with paragraph (d) of FAR clause 52.247-64).
	 	 	 	 	 
	 	 	(2)	While not
        required, the Contractor may flow down to subcontracts for commercial
        items a minimal number of additional clauses necessary to satisfy its
    contractual obligations.
	 	 	 	 	 
	 	(d)	The Contractor shall include the terms
        of this clause, including this paragraph (d), in subcontracts awarded
    under this contract.
	 	 	 	 	 

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N01 AI-30030

PART III

SECTION J – LIST OF ATTACHMENTS 

The following documents are attached
    and incorporated in this contract:

	1.	Statement
    of Work, September 26, 2003, 2 pages.
	 	 
	2.	Invoice/Financing
    Request and Contract Financial Reporting Instructions for NIH Cost-Reimbursement
    Type Contracts, NIH(RC)-4, (5/97), 6 pages.
	 	 
	3.	Inclusion
    Enrollment Report, 5/01 (Modified OAMP: 10/01), 1 page.
	 	 
	4.	Annual Technical
    Progress Report Format for Each Study, July 1994, 1 page.
	 	 
	5.	Safety and
    Health, HHSAR Clause 352.223-70, (1/01), 1 page.
	 	 
	6.	Research
    Patient Care Costs, NIH(RC)-11, 4/1/84, 1 page.
	 	 
	7.	Procurement
    of Certain Equipment, NIH(RC)-7, 4/1/84, 1 page.
	 	 

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PART IV

SECTION K – REPRESENTATIONS
      AND CERTIFICATIONS 

The following documents are incorporated
    by reference in this contract: 

	1.	Representations and Certifications, dated
    September 4, 2003.
	 	 
	2.	Progenics Pharmaceuticals, Inc., Human Subjects
    Assurance Identification Number FWA00003010, expires August 6, 2005.
	 	 
	3.	Weill Medical College of Cornell University,
    Human Subjects Assurance Identification Number FWA00000093,
    expires March 2, 2004.
	 	 
	4.	Tulane Regional Primate Research Center,
    Animal Welfare Assurance No. A3071-01, dated April 23, 2002.

 

END of the SCHEDULE

(CONTRACT)

 

 

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STATEMENT OF WORK

Independently, and not as an agent
    of the Government, the Contractor shall furnish all the necessary services,
    qualified personnel, materials, equipment, and facilities, not otherwise
    provided by the Government under the terms of this contract, as needed to
    perform the work set forth below. 

Specifically, the Contractor shall: 

	 	1.	Identify a specific vaccine concept
        to be pursued in a well planned and
        managed, comprehensive, multidisciplinary, targeted
        development effort culminating in the production and clinical
    testing of a promising AIDS vaccine candidate.
	 	 	 	 
	 	2.	Articulate and implement a strategic
    research plan that includes.
	 	 	 	 
	 	 	a.	key development objectives and a detailed
        work plan describing proposed time
        schedules for achieving contract objectives
        and milestones, and maintaining quality
        control over the implementation and operation of
    the contract
	 	 	 	 
	 	 	b.	how decisions to proceed or not proceed will
        be made (i.e. specific qualitative
        and quantitative criteria for advancement
        of vaccine molecules or constructs through
        each stage of preclinical product development)
        including decisions to proceed or not proceed
    vis a vis human safety, immunogenicity, and testing
	 	 	 	 
	 	 	c.	plans for GMP vaccine lot production and
        for obtaining the necessary government
    and ethical approvals to proceed.
	 	 	 	 
	 	 	 	The strategic plan shall articulate how the
        Team will efficiently allocate and
        utilize the resources, redirect the
        focus (including reallocation of funds) depending
        upon the project’s changing needs and emerging
        new knowledge, obtain patent coverage and licensing
        of the resulting HIV vaccine, and what procedures
        will be followed for the resolution of potential
    legal issues that may arise.
	 	 	 	 
	 	3.	Provide a research and administrative
        team that includes all expertise needed
        for the development, optimization, pre-clinical
        and clinical testing, and production of an HIV/AIDS
        vaccine
based on the concept chosen by the Contractor.
	 	 	 	 
	 	4.	Provide infrastructure, facilities,
        and resources for performing all phases
        of this contract, including production of
        an optimized vaccine under GMP (Good Manufacturing Practices,
        as defined in the US Code of Federal Regulations – 21 CFR        §211)
        conditions, GLP (Good Laboratory Practices – 21 CFR
        §58) performance of IND-enabling preclinical animal studies,
        and GCP (Good Clinical Practices – 21 CFR §312 and ICH
        Guidelines document E6) performance of clinical studies in humans
        if clinical studies will be performed by the Contractor,
        on its own, rather than through the DAIDS HIV Vaccine
    Trials Network.
	 	 	 	 
	 	5.	Report progress according to
        Reporting Requirements (refer to the “Deliverables
    and Reporting Requirements” in this contract).

 

	Statement of Work 	ATTACHMENT 1
	(September 26, 2003)	Page 1

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	 	6.	Meet with the Project Officer
        and the External Advisory Committee
    associated with this Contract,
	 	 	 	 
	 	 	a.	The Contractor and the NIH, after Contract
        award, shall jointly establish an
        External Advisory Committee for the
        contract. The Contractor’s key personnel
        shall meet with the Project Officer and the Team’s
        External Advisory Committee at periodic intervals
        to be scheduled after contract award to review
    progress and anticipated or existing problems.
	 	 	 	 
	 	 	b.	In the middle (6 month mark) of each contract
        year, the Contractor shall host a
        site visit review for NIAID contract
        and program staff, and their External Advisory
        Committee. The Contractor’s Principal Investigator
        and all co-investigators shall attend this
        meeting. The co-investigator and/or other pertinent
        staff shall present an update and summary of
        results generated on each sub-project. These presentations
        shall include summaries of all goals or milestones
        reached during the review period and a description
        of all problems encountered that will impact
        on the achievement of particular goals and milestones
        as outlined in the Contractor’s research plan.
        The Principal Investigator, co-investigator and staff
        representing each project and sub-project shall describe
        goals and milestones and development objectives
        for the coming year. Additionally, application
        of the policies and procedures for monitoring
        the direction of specific projects shall be
        presented. For contractors with foreign subcontracts,
        this annual site visit also will report details
        about: approvals for manufacturing or testing that
        have been obtained from both the U.S. and foreign
    governments.

    

    

     

	Statement of Work 	ATTACHMENT 1
	(September 26, 2003)	Page 2

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INVOICE/FINANCING REQUEST AND
      CONTRACT FINANCIAL REPORTING
INSTRUCTIONS FOR NIH COST-REIMBURSEMENT
      CONTRACTS NIH(RC)-4

General: The contractor shall submit
    claims for reimbursement in the manner and format described herein and as
    illustrated in the sample invoice/financing request. 

Format: Standard Form 1034, “Public
    Voucher for Purchases and Services Other Than Personal,” and Standard Form
    1035, “Public Voucher for Purchases and Services Other Than Personal–Continuation
    Sheet,” or reproduced copies of such forms marked ORIGINAL should be used
    to submit claims for reimbursement. In lieu of SF-1034 and SF-1035, claims
    may be submitted on the payee's letter-head or self-designed form provided
    that it contains the information shown on the sample invoice/financing request. 

Number of Copies: As indicated in
    the Invoice Submission Clause in the contract. 

Frequency: Invoices/financing requests
    submitted in accordance with the Payment Clause shall be submitted monthly
    unless otherwise authorized by the contracting officer. 

Cost Incurrence Period: Costs incurred
    must be within the contract performance period or covered by precontract
    cost provisions. 

Billing of Costs Incurred: If billed
    costs include: (1) costs of a prior billing period, but not previously billed;
    or (2) costs incurred during the contract period and claimed after the contract
    period has expired, the amount and month(s) in which such costs were incurred
    shall be cited. 

Contractor’s Fiscal Year: Invoices/financing
    requests shall be prepared in such a manner that costs claimed can be identified
    with the contractor's fiscal year. 

Currency: All NIH contracts are expressed
    in United States dollars. When payments are made in a currency other than
    United States dollars, billings on the contract shall be expressed, and payment
    by the United States Government shall be made, in that other currency at
    amounts coincident with actual costs incurred. Currency fluctuations may
    not be a basis of gain or loss to the contractor. Notwithstanding the above,
    the total of all invoices paid under this contract may not exceed the United
    States dollars authorized. 

Costs Requiring Prior Approval: Costs
    requiring the contracting officer's approval, which are not set forth in
    an Advance Understanding in the contract shall be so identified and reference
    the Contracting Officer's Authorization (COA) Number. In addition, any cost
    set forth in an Advance Understanding shall be shown as a separate line item
    on the request. 

Invoice/Financing Request Identification:  Each invoice/financing request shall be identified as either: 

	(a)	Interim Invoice/Contract Financing Request – These
        are interim payment requests submitted during the contract performance
    period.
	 	 
	(b)	Completion Invoice – The completion invoice
        is submitted promptly upon completion of the work; but no later than
    one year from the contract completion date, or within 120 days after

 

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 1

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	 	settlement of the final indirect cost rates
        covering the year in which this contract is physically complete (whichever
        date is later). The completion invoice should be submitted when all costs
        have been assigned to the contract and all performance provisions have
    been completed.
	 	 
	(c)	Final Invoice – A final invoice may
        be required after the amounts owed have been settled between the Government
    and the contractor (e.g., resolution of all suspensions and audit exceptions).
	 	 
	Preparation and Itemization
          of the Invoice/Financing Request: The contractor shall furnish the information set forth in the
        explanatory notes below. These notes are keyed to the entries on the
    sample invoice/financing request.
	 	 
	(a)	Designated Billing Office Name and Address
        – Enter the designated billing office and address, identified in the Invoice
        Submission Clause of the contract, on all copies of the invoice/financing
    request.
	 	 
	(b)	Invoice/Financing Request Number – Insert
    the appropriate serial number of the invoice/financing request.
	 	 
	(c)	Date Invoice/Financing Request Prepared – Insert
    the date the invoice/financing request is prepared.
	 	 
	(d)	Contract Number and Date – Insert the
    contract number and the effective date of the contract.
	 	 
	(e)	Payee’s Name and Address – Show the
        contractor's name (as it appears in the contract), correct address, and
        the title and phone number of the responsible official to whom payment
        is to be sent. When an approved assignment has been made by the contractor,
        or a different payee has been designated, then insert the name and address
    of the payee instead of the contractor.
	 	 
	(f)	Total Estimated Cost of Contract – Insert
        the total estimated cost of the contract, exclusive of fixed-fee. For
        incrementally funded contracts, enter the amount currently obligated
    and available for payment.
	 	 
	(g)	Total Fixed-Fee – Insert the total fixed-fee
        (where applicable). For incrementally funded contracts, enter the amount
    currently obligated and available for payment.
	 	 
	(h)	Billing Period – Insert the beginning
        and ending dates (month, day, and year) of the period in which costs
    were incurred and for which reimbursement is claimed.
	 	 
	(i)	Incurred Cost-Current – Insert the amount
        billed for the major cost elements, adjustments, and adjusted amounts
    for the current period.
	 	 
	(j)	Incurred Cost-Cumulative – Insert the
        cumulative amounts billed for the major cost elements and adjusted amounts
    claimed during this contract.
	 	 
	(k)	Direct Costs – Insert the major cost
        elements. For each element, consider the application of the paragraph
    entitled “Costs Requiring Prior Approval” on page 1 of these instructions.

 

 

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 2

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	 	 	(1)	Direct
          Labor — Include salaries and
        wages paid (or accrued) for direct performance of the contract. For Key
        Personnel, list each employee on a separate line. List other employees
    as one amount unless otherwise required by the contract.
	 	 	 	 	 
	 	 	(2)	Fringe
          Benefits —  List any fringe benefits
        applicable to direct labor and billed as a direct cost. Fringe benefits
    included in indirect costs should not be identified here.
	 	 	 	 	 
	 	 	(3)	Accountable
          Personal Property — Include
        permanent research equipment and general purpose equipment having a unit
        acquisition cost of $1,000 or more and having an expected service life
        of more than two years, and sensitive property regardless of cost (see
        the DHHS Contractor’s Guide for Control of Government Property). Show
        permanent research equipment separate from general purpose equipment.
        Prepare and attach Form HHS-565, “Report of Accountable Property,” in
    accordance with the following instructions:
	 	 	 	 	 
	 	 	 	List each item for which reimbursement is
    requested. A reference shall be made to the following (as applicable):
	 	 	 	 	 
	 	 	 	-	The item number for the specific piece of
    equipment listed in the Property Schedule.
	 	 	 	 	 
	 	 	 	-	The Contracting Officer’s Authorization letter
    and number, if the equipment is not covered by the Property Schedule.
	 	 	 	 	 
	 	 	 	-	Be preceded by an asterisk (*) if the equipment
    is below the approval level.
	 	 	 	 	 
	 	 	(4)	Materials
        and Supplies — Include equipment with unit costs of less than $1,000 or
        an expected service life of two years or less, and consumable material
    and supplies regardless of amount.
	 	 	 	 
	 	 	(5)	Premium
    Pay — List remuneration in excess of the basic hourly rate.
	 	 	 	 
	 	 	(6)	Consultant
        Fee — List fees paid to consultants. Identify consultant by name
        or category as set forth in the contract’s Advance Understanding or in
        the COA letter, as well as the effort (i.e., number of hours, days, etc.)
    and rate being billed.
	 	 	 	 
	 	 	(7)	Travel — Include
        domestic and foreign travel. Foreign travel is travel outside of Canada,
        the United States and its territories and possessions. However, for an
        organization located outside Canada, the United States and its territories
        and possessions, foreign travel means travel outside that country. Foreign
    travel must be billed separately from domestic travel.
	 	 	 	 
	 	 	(8)	Subcontract
    Costs — List subcontractor(s) by name and amount billed.
	 	 	 	 
	 	 	(9)	Other —      List
        all other direct costs in total unless exceeding $1,000 in amount. If
        over $1,000, list cost elements and dollar amounts separately. If the
        contract contains restrictions on any cost element, that cost element
    must be listed separately.
	 	 	 	 
	 	(l)	Cost
        of Money (COM) — Cite the COM factor and base in effect during the
    time the cost was incurred and for which reimbursement is claimed.

 

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 3

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	 	(m)	Indirect Costs-Overhead — Identify
        the cost base, indirect cost rate, and amount billed for each indirect
        cost
    category.
	 	 	 
	 	(n)	Fixed-Fee Earned — Cite the formula
        or method of computation for the fixed-fee (if any). The fixed-fee must
    be claimed as provided for by the contract.
	 	 	 
	 	(o)	Total Amounts Claimed — Insert the total
    amounts claimed for the current and cumulative periods.
	 	 	 
	 	(p)	Adjustments — Include amounts conceded
        by the contractor, outstanding suspensions, and/or disapprovals subject
    to appeal.
	 	 	 
	 	(q)	Grand Totals
	 	 	 
	 	The contracting officer may
          require the contractor to submit detailed support for costs claimed
          on one or more interim invoices/financing
    requests.

 

 

 

 

 

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 4

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FINANCIAL REPORTING INSTRUCTIONS: 

These instructions are keyed to the
    Columns on the sample invoice/financing request. 

Column A—Expenditure Category – Enter
    the expenditure categories required by the contract. 

Column B—Cumulative Percentage
    of Effort/Hrs.-Negotiated – Enter the percentage of effort or number
    of hours agreed to doing contract negotiations for each employee or labor
    category listed in Column A. 

Column C—Cumulative Percentage
    of Effort/Hrs.-Actual – Enter the percentage of effort or number
    of hours worked by each employee or labor category listed in Column A. 

Column D—Incurred Cost-Current – Enter
    the costs, which were incurred during the current period. 

Column E—Incurred Cost-Cumulative – Enter
    the cumulative cost to date. 

Column F—Cost at Completion – Enter
    data only when the contractor estimates that a particular expenditure category
    will vary from the amount negotiated. Realistic estimates are essential. 

Column G— Contract Amount – Enter
    the costs agreed to during contract negotiations for all expenditure categories
    listed in Column A. 

Column H—Variance (Over or Under) – Show
    the difference between the estimated costs at completion (Column F) and negotiated
    costs (Column G) when entries have been made in Column F. This column need
    not be filled in when Column F is blank. When a line item varies by plus
    or minus 10 percent, i.e., the percentage arrived at by dividing Column F
    by Column G, an explanation of the variance should be submitted. In the case
    of an overrun (net negative variance), this submission shall not be deemed
    as notice under the Limitation of Cost (Funds) Clause of the contract. 

Modifications: Any modification in
    the amount negotiated for an item since the preceding report should be listed
    in the appropriate cost category. 

Expenditures Not Negotiated: An expenditure
    for an item for which no amount was negotiated (e.g., at the discretion of
    the contractor in performance of its contract) should be listed in the appropriate
    cost category and all columns filled in, except for G. Column H will of course
    show a 100 percent variance and will be explained along with those identified
    under H above.

 

 

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 5

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SAMPLE INVOICE/FINANCING REQUEST
      AND CONTRACT FINANCIAL REPORT 

	  (a)    Billing Office Name and Address

      

                    NATIONAL
        INSTITUTES OF HEALTH

                    National
        Institute of Allergy and Infectious Diseases

                    Room
        2230. MSC 7612

                    6700-B
        Rockledge Drive

            Bethesda,
MD 20892-7612

            

  (e)     Payee's
Name and Address

            ABC CORPORATION

            100
Main Street

            Anywhere, USA zip code

            

Attn:   
Name, Title, & Phone Number
of Official to

            Whom Payment is Sent	  (b)    Invoice/Financing Request No.                                                                  

      

  (c)    Date
      Invoice Prepared                                                                              

      

  (d)    Contract
      No.                                                                                           

      

            Effective
      Date                                                                                          

  (f)
          Total Estimated Cost                                                                               

      

  (g)    Total
      Fixed Fee                                                                                       

    

	(h)       This invoice/financing request represents
    reimbursable costs for the period from __________ to __________  

	Expenditure Category*

        A	Cumulative

        Percentage
of
Effort/Hrs.	Incurred Cost	Cost
    at
Completion

        F	Contract
Amount

        G	Variance

        H
	Negotiated

        B	Actual

        C	(i)
    Current

        D	(j)
    Cumulative

        E
	(k) Direct Costs: 	 	 	 	 	 	 	 
	 (1)
    Direct Labor 
	 	 	 	 	 	 	 
	 (2)
    Fringe Benefits 
	 	 	 	 	 	 	 
	(3)
    Accountable property (attach HHS-565) 
	 	 	 	 	 	 	 
	 (4)
    Materials & Supplies 
	 	 	 	 	 	 	 
	 (5)
    Premium Pay 
	 	 	 	 	 	 	 
	 (6)
    Consultant Fees 
	 	 	 	 	 	 	 
	 (7)
    Travel 
	 	 	 	 	 	 	 
	 (8)
    Subcontracts 
	 	 	 	 	 	 	 
	 (9)
    Other 
	 	 	 	 	 	 	 
	Total Direct Costs	 	 	 	 	 	 	 
	 (l) Cost of Money 	 	 	 	 	 	 	 
	(m) Overhead 	 	 	 	 	 	 	 
	      G&A 	 	 	 	 	 	 	 
	 (n) Fixed Fee 	 	 	 	 	 	 	 
	 (o) Total Amount Claimed 	 	 	 	 	 	 	 
	 (p) Adjustments 	 	 	 	 	 	 	 
	 (q) Grand Totals   	 	 	 	 	 	 	 
	I certify that all payments are for
    appropriate purposes and in accordance with the contract.
 
                                                    
                        
                                                     

               (Name
        of Official)                      
                                  (Tit1e)
 

        

     * Attach details as specified in the contract

    

	NIH(RC)-4	ATTACHMENT 2
	Rev. 5/97	Page 6

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INCLUSION ENROLLMENT REPORT

This report format should NOT be
    used for data collection from study participants

	Study Title:
	Total Enrollment:	Protocol Number:
	Contract Number: 	 

	PART A. TOTAL ENROLLMENT REPORT:
    Number of Subjects Enrolled to Date (Cumulative) by Ethnicity and Race
	Ethnic Category	 Sex/Gender
	Females	Males	Unknown or Not Reported	Total
	Hispanic or Latino	 	 	 	 
	Not Hispanic or Latino	 	 	 	 
	Unknown (Individuals not reporting
        ethnicity)	 	 	 	 
	Ethnic Category: Total of All Subjects*	 	 	 	 
	Racial Categories	 	 	 	 
	American
Indian/Alaska Native	 	 	 	 
	Asian	 	 	 	 
	Native Hawaiian or Other Pacific Islander	 	 	 	 
	Black or African American	 	 	 	 
	White	 	 	 	 
	More than one race	 	 	 	 
	Unknown or not reported	 	 	 	 
	Racial Categories: Total of All Subjects*	 	 	 	 
	 
	PART B. HISPANIC ENROLLMENT REPORT:
    Number of Hispanics or Latinos Enrolled to Date (Cumulative) 
	Racial Categories	Females	Males	Unknown
or Not Reported	Total
	American Indian or Alaska Native	 	 	 	 
	Asian	 	 	 	 
	Native Hawaiian or Other Pacific Islander	 	 	 	 
	Black or African American	 	 	 	 
	White	 	 	 	 
	More Than One Race	 	 	 	 
	Unknown or not reported	 	 	 	 
	Racial Categories: Total of Hispanics
    or Latinos**	 	 	 	 
	 *These totals must agree 

**These totals must agree 	 	 	 	 

 

	Inclusion Enrollment Report	ATTACHMENT 3
	5/2001 (Modified OAMP: October, 2001)	 

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 ANNUAL TECHNICAL PROGRESS
        REPORT
FORMAT FOR EACH STUDY

Study Title: 

Date: 

Provide the number of subject enrolled
    in the study to date according to the following categories: 

	 	American Indian
or Alaskan Native	Asian
or Pacific Islander	Black, not
of Hispanic Origin	Hispanic	White, not
of Hispanic Origin	Other or Unknown	Total
	Female	 	 	 	 	 	 	 
	Male	 	 	 	 	 	 	 
	Unknown	 	 	 	 	 	 	 
	TOTAL	 	 	 	 	 	 	 

Subpopulations of the minority groups
should also be reported, using a similar format. 

 

	Annual Technical Progress Report Format	ATTACHMENT 4
	July, 1994	 

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HHSAR 352.223-70 SAFETY AND
HEALTH (JANUARY 2001)

	(a)	To help ensure the protection of the life
        and health of all persons, and to help prevent damage to property, the
        Contractor shall comply with all Federal, State and local laws and regulations
        applicable to the work being performed under this contract. These laws
        are implemented and/or enforced by the Environmental Protection Agency,
        Occupational Safety and Health Administration and other agencies at the
        Federal, State and local levels (Federal, State and local regulatory/enforcement
    agencies).
	 	 
	(b)	Further, the Contractor shall take or cause
        to be taken additional safety measures as the Contracting Officer in
        conjunction with the project or other appropriate officer, determines
        to be reasonably necessary. If compliance with these additional safety
        measures results in an increase or decrease in the cost or time required
        for performance of any part of work under this contract, an equitable
        adjustment will be made in accordance with the applicable “Changes” Clause
    set forth in this contract.
	 	 
	(c)	The Contractor shall maintain an accurate
        record of, and promptly report to the Contracting Officer, all accidents
        or incidents resulting in the exposure of persons to toxic substances,
        hazardous materials or hazardous operations; the injury or death of any
        person; and/or damage to property incidental to work performed under
        the contract and all violations for which the Contractor has been cited
        by any Federal, State or local regulatory/enforcement agency. The report
        shall include a copy of the notice of violation and the findings of any
        inquiry or inspection, and an analysis addressing the impact these violations
        may have on the work remaining to be performed. The report shall also
        state the required action(s), if any, to be taken to correct any violation(s)
        noted by the Federal, State or local regulatory/enforcement agency and
        the time frame allowed by the agency to accomplish the necessary corrective
    action.
	 	 
	(d)	If the Contractor fails or refuses to comply
        promptly with the Federal, State or local regulatory/enforcement agency’s
        directive(s) regarding any violation(s) and prescribed corrective action(s),
        the Contracting Officer may issue an order stopping all or part of the
        work until satisfactory corrective action (as approved by the Federal,
        State or local regulatory/enforcement agencies) has been taken and documented
        to the Contracting Officer. No part of the time lost due to any stop
        work order shall be subject to a claim for extension of time or costs
    or damages by the Contractor.
	 	 
	(e)	The Contractor shall insert the substance
        of this clause in each subcontract involving toxic substances, hazardous
        materials, or operations. Compliance with the provisions of this clause
    by subcontractors will be the responsibility of the Contractor.

(End of clause)

     

 

	Safety and Health Clause	ATTACHMENT 5
	HHSAR 352.223-70, (1/01)	 

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RESEARCH PATIENT CARE COSTS

	(a)	Research patient care costs are the costs
        of routine and ancillary services provided to patients participating
    in research programs described in this contract.
	 	 
	(b)	Patient care costs shall be computed in a
        manner consistent with the principles and procedures used by the Medicare
        Program for determining the part of Medicare reimbursement based on reasonable
        costs. The Diagnostic Related Group (DRG) prospective reimbursement method
        used to determine the remaining portion of Medicare reimbursement shall
        not be used to determine patient care costs. Patient care rates or amounts
    shall be established by the Secretary of HHS or his duly authorized representative.
	 	 
	(c)	Prior to submitting an invoice for patient
        care costs under this contract, the contractor must make every reasonable
        effort to obtain third party payment, where third party payors (including
        Government agencies) are authorized or are under a legal obligation to
        pay all or a portion of the charges incurred under this contract for
    patient care.
	 	 
	(d)	The contractor must maintain adequate procedures
        to identify those research patients participating in this contract who
    are eligible for third party reimbursement.
	 	 
	(e)	Only those charges not recoverable from third
        party payors or patients and which are consistent with the terms and
    conditions of the contract are chargeable to this contract.

 

	NIH(RC)-11	ATTACHMENT 6
	(4/1/84)	 

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PROCUREMENT OF CERTAIN EQUIPMENT

Notwithstanding any other clause
    in this contract, the Contractor will not be reimbursed for the purchase,
    lease, or rental of any item of equipment listed in the following Federal
    Supply Groups, regardless of the dollar value, without the prior written
    approval of the Contracting Officer. 

	 	67	 	–	 	Photographic Equipment
	 	69	 	–	 	Training Aids and Devices
	 	70	 	–	 	General Purpose ADP Equipment, Software,
    Supplies and Support (Excluding 7045-ADP Supplies and Support Equipment.)
	 	71	 	–	 	Furniture
	 	72	 	–	 	Household and Commercial Furnishings and
    Appliances
	 	74	 	–	 	Office Machines and Visible Record Equipment
	 	77	 	–	 	Musical Instruments, Phonographs, and Home-type
    Radios
	 	78	 	–	 	Recreational and Athletic Equipment

When equipment in these Federal Supply
    Groups is requested by the Contractor and determined essential by the Contracting
    Officer, the Government will endeavor to fulfill the requirement with equipment
    available from its excess personal property sources, provided the request
    is made under a contract. Extensions or renewals of approved existing leases
    or rentals for equipment in these Federal Supply Groups are excluded from
    the provisions of this article. 

     

 

 

 

 

	NIH(RC)-7 (4/1/84)	ATTACHMENT 7
	OMB Bulletin 81-16Prepared and filed by St Ives Burrups

Exhibit 10.26

 

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AGREEMENT OF LEASE

  

between

EASTVIEW HOLDINGS LLC,

Landlord

and

PROGENICS PHARMACEUTICALS, INC.,

Tenant

Dated: September 30, 2003

  

  The Landmark at Eastview

Towns of Greenburgh

and Mount Pleasant

Westchester County, New York

 

 

	TABLE OF CONTENTS
	 

	 	 	 	 	Page	 
	 	 	 	 	 	 
	ARTICLE 1
	 	GLOSSARY	 	4	 
	ARTICLE 2
	 	DEMISE, PREMISES, TERM, RENT	 	8	 
	ARTICLE 3
	 	TENANT’S
    TAX PAYMENT	 	9	 
	ARTICLE 4
	 	TENANT’S
    OPERATING PAYMENT	 	11	 
	ARTICLE 5
	 	USE AND OCCUPANCY	 	16	 
	ARTICLE 6
	 	ALTERATIONS	 	17	 
	ARTICLE 7
	 	REPAIRS; FLOOR LOAD	 	20	 
	ARTICLE 8
	 	WINDOW CLEANING	 	22	 
	ARTICLE 9
	 	REQUIREMENTS OF LAW	 	22	 
	ARTICLE 10
	 	SUBORDINATION	 	26	 
	ARTICLE 11
	 	RULES AND REGULATIONS	 	29	 
	ARTICLE 12
	 	INSURANCE, PROPERTY LOSS OR DAMAGE; REIMBURSEMENT	 	29	 
	ARTICLE 13
	 	DESTRUCTION BY FIRE OR OTHER CAUSE	 	32	 
	ARTICLE 14
	 	EMINENT DOMAIN	 	33	 
	ARTICLE 15
	 	ASSIGNMENT, SUBLETTING, MORTGAGE, ETC.	 	34	 
	ARTICLE 16
	 	ACCESS TO PREMISES	 	41	 
	ARTICLE 17
	 	CERTIFICATE OF OCCUPANCY	 	43	 
	ARTICLE 18
	 	DEFAULT	 	43	 
	ARTICLE 19
	 	REMEDIES AND DAMAGES	 	46	 
	ARTICLE 20
	 	FEES AND EXPENSES	 	48	 
	ARTICLE 21
	 	NO REPRESENTATIONS BY LANDLORD	 	49	 
	ARTICLE 22
	 	END OF TERM	 	49	 
	ARTICLE 23
	 	POSSESSION	 	50	 
	ARTICLE 24
	 	NO WAIVER	 	51	 
	ARTICLE 25
	 	WAIVER OF TRIAL BY JURY	 	52	 
	ARTICLE 26
	 	INABILITY TO PERFORM	 	52	 
	ARTICLE 27
	 	BILLS AND NOTICES	 	53	 
	ARTICLE 28
	 	SERVICES AND EQUIPMENT	 	54	 
	ARTICLE 29
	 	PARTNERSHIP TENANT	 	58	 
	ARTICLE 30
	 	ELECTRIC ENERGY	 	58	 
	ARTICLE 31
	 	SIGNS	 	60	 
	ARTICLE 32
	 	BROKER	 	60	 
	ARTICLE 33
	 	INDEMNITY	 	61	 
	ARTICLE 34
	 	PARKING	 	62	 
	ARTICLE 35
	 	SECURITY DEPOSIT	 	62	 
	ARTICLE 36
	 	RENT REGULATION	 	64	 
	ARTICLE 37
	 	ALTERNATIVE SPACE	 	64	 
	ARTICLE 38
	 	COVENANT OF QUIET ENJOYMENT	 	64	 
	ARTICLE 39
	 	MISCELLANEOUS	 	65	 
	ARTICLE 40
	 	EXISTING FURNITURE AND IMPROVEMENTS	 	69	 
	ARTICLE 41
	 	APPROVAL CONTINGENCY	 	69	 

 

(i)

	ARTICLE 42

    	  	REIMBURSEMENT
    FOR RELOCATION OF COMMON CONFERENCE ROOM	 	 70	 
	ARTICLE 43
	 	RENEWAL OPTIONS	 	70	 
	 	 	 	 	 	 
	SCHEDULE A -
	 	Floor Plan of the Premises	 	 	 
	SCHEDULE B - 
	 	The Building	 	 	 
	SCHEDULE C - 
	 	Rules and Regulations	 	 	 
	SCHEDULE D - 
	 	Cleaning Specifications	 	 	 
	SCHEDULE E - 
	 	Furniture, Equipment and Improvements	 	 	 
	SCHEDULE F - 
	 	Form of Letter of Credit	 	 	 
	SCHEDULE G - 
	 	HVAC Model	 	 	 
	SCHEDULE H -
	 	Parking Plan	 	 	 
	SCHEDULE I -
	 	Fixed Rent	 	 	 

 

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AGREEMENT OF LEASE, made as of the 30th day of September, 2003, between EASTVIEW HOLDINGS LLC, a Delaware limited liability company, having an address at c/o LCOR Asset Management L.P., One Penn Plaza, Suite 3310, New York, New York 10119, as
 Landlord, and PROGENICS PHARMACEUTICALS, INC., a Delaware corporation, having an address at 777 Old Saw Mill River Road, Tarrytown, New York 10591, as Tenant.

REFERENCE PAGE

In addition to other terms elsewhere defined in this Lease, the following terms whenever used in this Lease shall have the meanings set forth in this Reference Page.

	 	(1)	Space A 

        Premises:	Collectively, (i) the portion of the First Floor of the Spine Building, as approximately shown hatched on the floor plan annexed hereto as Schedule
            A-1, containing approximately 13,912 square feet of rentable area, and (ii)
 the portion of the Mezzanine Level of the Linde Building, as approximately shown hatched on the floor plan annexed hereto as Schedule
 A-2, containing approximately 7,222 square feet of rentable area. For all purposes
 under this Lease, Space A Premises is conclusively deemed to contain a total of 21,134 square feet of rentable area.

	 	 	 	 
	 	(2)	Space B 

        Premises:	The portion of the First Floor of the Spine Building, as approximately shown hatched on the floor plan annexed hereto as Schedule
            A-3. For all purposes under this Lease, Space B Premises are conclusively deemed to
 contain 2,721 square feet of rentable area.

	 	 	 	 
	 	(3)	Space C 

        Premises:	The portion of the First Floor of the Spine Building, as approximately shown hatched on the floor plan annexed hereto as Schedule
            A-4. For all purposes under this Lease, Space C Premises are conclusively deemed to
 contain 7,888 square feet of rentable area.

	 	 	 	 
	 	(4)	Space D 

        Premises:	The portion of the First Floor of the Spine Building, as approximately shown hatched on the floor plan annexed hereto as Schedule
            A-4. For all purposes under this Lease, Space D Premises are conclusively deemed to
 contain 2,056 square feet of rentable area.

	 	 	 	 
	 	(5)	Premises:	Collectively, the Space A Premises, the Space B Premises, the Space C Premises and the Space D Premises. For all purposes under this Lease, the Premises are conclusively deemed to contain a total of 33,799 square feet
 of rentable area.

 

 

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	 	(6)	Linde Building:	The building known as the Linde Building, having a street address of 765 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule
            B.

	 	 	 	 
	 	(7)	Spine Building	The building known as the Spine Building, having a street address of 777 Old Saw Mill River Road, Tarrytown, New York, and identified on the plan annexed hereto as Schedule
            B.

	 	 	 	 
	 	(8)	Building:	Collectively, the Spine Building and the Linde Building identified on the plan annexed hereto as Schedule
            B. The Building is part of a larger development located along Old Saw Mill River Road, partly in the Town of
 Greenburgh and partly in the Town of Mount Pleasant, in the County of Westchester and State of New York and called “The Landmark at Eastview.”

	 	 	 	 	 
	 	(9)	Commencement Date:	Space A Premises:	October 23, 2003

	 	 	 	 	 
	 	 	 	Space B Premises:	March 15, 2004

	 	 	 	 	 
	 	 	 	Space C Premises:	December 15, 2003 (Subject to Article 23)

	 	 	 	 	 
	 	 	 	Space D Premises:	March 1, 2004 (Subject to Article 23)

	 	 	 	 
	 	(10)	Fixed Expiration Date:	December 31, 2009

	 	 	 	 
	 	(11)	Term:	Space A Premises: Six Years
          and [Two and One-Half Months]

          Space B Premises: Five Years and [Nine and One-Half Months]

Space C Premises: Six Years and One-Half Month

Space D Premises: Five Years and Ten Months

	 	 	 	 
	 	(12)	Fixed Rent:	Fixed Rent is set forth on Schedule I attached hereto and made a part hereof

 

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	 	(13)	Tenant’s Tax Proportionate Share:	The Tenant’s Tax Proportionate Share shall be equal to the aggregate of the percentages listed below, but subject to change as provided in Sections 3.6 and 3.7. Upon the respective Commencement Date for each of the
 spaces that comprise the Premises, the Tenant’s Tax Proportionate Share shall be increased to reflect the addition of such space to the Premises. Upon the latest Commencement Date to occur the Tenant’s Tax
 Proportionate Share shall mean 4.56%.

	 	 	 	 	 

	 	 	 	Space A
 Premises:	2.85%
	 	 	 	Space B
 Premises:	0.37%

	 	 	 	Space C
 Premises:	1.06%

	 	 	 	Space D
 Premises:	0.28%
	 	 	 	 	

	 	 	 	Total:	4.56%

	 	 	 	 
	 	 	 	For purposes of determining Tenant’s Tax Proportionate Share, Landlord and Tenant agree that as of the date of this Lease, the aggregate number of square feet of rentable area of all
 buildings on the Land is conclusively deemed to be 741,495.

	 	 	 	 
	 	(14)	Tenant’s Operating Proportionate Share:	The Tenant’s Operating Proportionate Share shall be equal to the aggregate of the percentages listed below, but subject to change as provided in Section 4.7. Upon the respective Commencement Date for each of the spaces
 that comprise the Premises, the Tenant’s Operating Proportionate Share shall be increased to reflect the addition of such space to the Premises. Upon the latest Commencement Date to occur the Tenant’s Operating
 Proportionate Share shall mean 4.56%.

	 	 	 	 	 

	 	 	 	Space A
 Premises:	2.85%
	 	 	 	Space B
 Premises:	0.37%

	 	 	 	Space C
 Premises:	1.06%

	 	 	 	Space D
 Premises:	0.28%

	 	 	 	 	

	 	 	 	Total:	4.56%

	 	 	 	 
	 	 	 	For purposes of determining Tenant’s Operating Proportionate Share, Landlord and Tenant agree that as of the date of this Lease, the aggregate number of square feet of rentable area of all
 buildings comprising the Core Campus is conclusively deemed to be 741,495.

 

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	 	(15)	Security Deposit:	$200,000.

	 	 	 	 
	 	(16)	Permitted Use:	Research and development of pharmaceutical products and for the manufacturing of clinical grade products (not to include commercial manufacturing) and general, executive and administrative offices in connection
 therewith and uses incidentally and directly related to the foregoing.

	 	 	 	 
	 	(17)	Broker(s):	LCOR Asset Management L.P. and Insignia/ESG.

	 	 	 	 
	 	(18)	Number of Parking Spaces:	101

	 	 	 	 
	 	(19)	Renewal Options:	Two renewal options for five (5) years each.

W I T N E S E T H:

The parties hereto, for themselves, their legal representatives, successors and assigns, hereby agree as follows:

ARTICLE 1

GLOSSARY

The following terms shall have the meanings indicated below:

“Additional Rent” shall have the meaning set forth in Section 2.2.

“Alteration Fee” shall have the meaning set forth in Section 6.2.

“Alterations” shall mean alterations, decorations, installations, repairs, improvements, additions, replacements or other physical changes in or about the Premises.

“Applicable Rate” shall mean the lesser of (x) four percentage points above the then current Base Rate, and (y) the maximum rate permitted by applicable law.

“Approved Examiner” shall have the meaning set forth in Section 4.5.

“ASHRAE” shall mean the American Society of Heating, Refrigeration and Air-Conditioning Engineers.

“Bankruptcy Code” shall mean 11 U.S.C. Section 101 et seq., or any statute, federal or state, of similar nature and purpose.

 

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“Base Rate” shall mean the rate of interest publicly announced from time to time by Citibank, N.A., or its successor, as its “base rate” (or such other term as may be used by Citibank, N.A., from time to time, for the rate presently referred to as its “base rate”).

“Building” shall include the building, equipment and other improvements and appurtenances of every kind and description now located or hereafter erected, constructed or placed upon the land beneath or immediately adjacent to the Building and any and all alterations,
 renewals, and replacements thereof, additions thereto and substitutions therefor.

“Building Systems” shall mean the base building mechanical, electrical, sanitary, heating, air conditioning, ventilating, elevator, plumbing, life-safety and other service systems of the Building, including the central plant which distributes electric steam and chilled water to the
 Project, but shall not include installations made by Tenant or fixtures or appliances.

“Business Days” shall mean all days, excluding Saturdays, Sundays and all days observed as holidays by the State of New York, the federal government or the labor unions servicing the Building.

“Control” shall have the meaning set forth in Section
  15.3.

“Core Campus” shall mean, as of the date of this Lease, the following buildings located in the Project, which the parties agree conclusively contain the following square feet of rentable area: Spine Building, 777 Old Saw Mill River Road, comprised of 285,811 rentable square
 feet; Linde Building, 765 Old Saw Mill River Road, comprised of 193,756 rentable square feet; Chemicals Building, 767 Old Saw Mill River Road, comprised of 71,340 rentable square feet; Silicones Building, 769 Old Saw Mill River Road, comprised of 100,357 rentable square feet;
 Building 771, 771 Old Saw Mill River Road, comprised of 71,111 rentable square feet; MT Building, 767A Old Saw Mill River Road, comprised of 7,759 rentable square feet; Annex Building, 767B Old Saw Mill River Road, comprised of 9,171 square feet and Autoclave, 767C Old
 Saw Mill River Road, comprised of 2,190 rentable square feet, but after the date of this Lease, Core Campus is subject to change as provided in Section
 4.7.

“Deficiency” shall have the meaning set forth in Section
  19.2.

“Event of Default” shall have the meaning set forth in Section
  18.1.

“Expiration Date” shall mean the Fixed Expiration Date or such earlier or later date on which the Term sooner or later ends pursuant to any of the terms, conditions or covenants of this Lease or pursuant to law.

“Government Authority (Authorities)” shall mean the United States of America, the State of New York, the County of Westchester, any political subdivision thereof and any agency, department, commission, board, bureau or instrumentality of any of the foregoing, now
 existing or hereafter created, having jurisdiction over the Real Property or any portion thereof.

“HVAC” shall mean heat, ventilation and air conditioning.

 

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“HVAC System” shall mean the Building Systems providing HVAC.

“Hazardous Materials” shall have the meaning set forth in Section 9.2.

“Improvements” shall mean the buildings and other improvements presently or hereafter located on the Land.

“Indemnitees” shall mean Landlord, its trustees, partners, shareholders, officers, directors, employees, agents and contractors and the Manager (and the partners, shareholders, officers, directors and employees of Landlord’s agents and contractors and of the Manager).

“Insurance Requirements” shall mean the rules, regulations, orders and requirements of the New York Board of Underwriters and/or the New York Fire Insurance Rating Organization and/or any other similar body performing the same or similar functions and having
 jurisdiction or cognizance over the Building or the Premises, whether now or hereafter in force, and the requirements of any insurance policy maintained by Landlord.

“Land” shall mean the land as of the date of this Lease on which The Landmark at Eastview is located but thereafter, if title to any portion of the Land is transferred to an entity not controlled by, under common control with, or controlling, Landlord, then “Land” shall mean
 only that portion of the Land not having been so transferred.

“Landlord” on the date as of which this Lease is made, shall mean Eastview Holdings LLC, a Delaware limited liability company, but thereafter, “Landlord” shall mean only the fee owner of the Real Property or, if there then exists a Superior Lease, the tenant thereunder.

“Landlord’s Operating Statement” shall mean a statement containing a computation of Additional Rent due pursuant to the provisions of Article 4 furnished by Landlord to Tenant.

“Landlord’s Statement” shall mean either a Landlord’s Operating Statement or a Landlord’s Tax Statement.

“Landlord’s Tax Statement” shall mean a statement containing a computation of Additional Rent due pursuant to the provisions of Article 3 furnished by Landlord to Tenant.

“Lease Year” or “Lease Years” shall mean each twelve (12) month period beginning on the first day of the calendar month immediately following the month in which the Commencement Date occurs and each twelve (12) month period thereafter beginning on the anniversary
 of the first day of the calendar month immediately following the month in which the Commencement Date occurs; provided, however, the first “Lease Year” shall include the number of days from the Commencement Date through the last day of the calendar month in which the
 Commencement Date occurs.

“Lessor(s)” shall mean a lessor under a Superior Lease.

“Manager” shall mean LCOR Asset Management L.P., a Delaware limited partnership, or any successor contractor under Landlord’s contract for the management of the Building.

 

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“Mortgage(s)” shall mean any trust indenture or mortgage which may now or hereafter affect the Real Property, the Building or any Superior Lease and the leasehold interest created thereby, and all renewals, extensions, supplements, amendments, modifications,
 consolidations and replacements thereof or thereto, substitutions therefor, and advances made thereunder.

“Mortgagee(s)” shall mean any trustee under or mortgagee or holder of a Mortgage.

“Notice(s)” shall have the meaning set forth in Section 27.1.

“Operating Expenses” shall have the meaning set forth in Article 4.

“Operating Hours” shall mean 24 hours per day, seven days per week, 365 days per year.

“Operating Year” shall mean each calendar year that includes any part of the Term.

“Parties” shall have the meaning set forth in Section 39.2.

“Partnership Tenant” shall have the meaning set forth in Article 29.

“Person(s) or person(s)” shall mean any natural person or persons, a partnership, a corporation and any other form of business or legal association or entity.

“Persons Within Tenant’s Control” shall mean and include Tenant, all of Tenant’s respective principals, officers, agents, contractors, servants, employees, licensees and invitees.

“Project” or “Real Property” (which are used interchangeably) shall mean the Land, the Building and all other buildings and other improvements presently and hereafter located on the Land.

“Rental” shall mean and be deemed to include Fixed Rent, Additional Rent and any other sums payable by Tenant hereunder.

“Requirements” shall mean (i) all present and future laws, rules, ordinances, regulations, statutes, requirements, codes and executive orders, extraordinary as well as ordinary, retroactive and prospective, of all Government Authorities now existing or hereafter created, and of
 any applicable fire rating bureau, or other body exercising similar functions, affecting the Real Property, or any street, avenue or sidewalk comprising a part or in front thereof or any vault in or under the same, or requiring removal of any encroachment, or affecting the maintenance, use
 or occupation of the Real Property, (ii) all requirements, obligations and conditions of all instruments of record on the date of this Lease, and (iii) all Insurance Requirements.

“Rules and Regulations” shall mean the rules and regulations annexed hereto as Schedule
      C, and such other and further reasonable non-discriminatory rules and regulations and standards as Landlord and Landlord’s agents may from time to time adopt, on notice to Tenant to
 be given as Landlord may elect.

 

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“Superior Lease(s)” shall mean all ground or underlying leases of the Real Property or the Building heretofore or hereafter made by Landlord and all renewals, extensions, supplements and modifications thereof.

“Taxes” shall have the meaning set forth in Section 3.1.

“Tax Year” shall have the meaning set forth in Section 3.1.

“Tenant”, on the date as of which this Lease is made, shall mean the Tenant named in this Lease, but thereafter “Tenant” shall mean only the tenant under this Lease at the time in question; provided, however, that the Tenant named in this Lease and any successor tenant
 hereunder shall not, except as otherwise provided herein or otherwise agreed to in writing by Landlord, be released from liability hereunder in the event of any assignment of this Lease.

“Tenant’s Operating Payment” shall have the meaning set forth in Section 4.2.

“Tenant’s Property” shall mean Tenant’s trade fixtures, movable fixtures and movable partitions, telephone and other equipment, furniture, furnishings and other movable items of personal property.

“Tenant’s Tax Payment” shall have the meaning set forth in Section 3.3.

“Unavoidable Delays” shall have the meaning set forth in Article 26.

ARTICLE 2

DEMISE, PREMISES, TERM, RENT

Section 2.1    Landlord hereby leases to Tenant and Tenant hereby hires from Landlord the Premises for the Term to commence, subject to Article
  23, on the Commencement Date and to end on the Expiration Date.

Section 2.2    Commencing upon the Commencement Date, Tenant shall pay to Landlord, in lawful money of the United States of America, without notice or demand, either by (i) good and sufficient check drawn to Landlord’s order on a bank or trust company with an office
 in the State of New York, at Eastview Holdings LLC, c/o First Union National Bank, P.O. Box 8500-4985, Philadelphia, Pennsylvania, 19178-4985, or (ii) wire transfer to the following account: First Union National Bank, ABA No. 031-201-467, Account No. 2000003297504 for credit
 to CDC Mortgage Capital Inc., as Mortgagee of Eastview Holdings LLC, or at such other place, or to Landlord’s agent and at such other place, as Landlord may designate from time to time, the following:

(A)    the Fixed Rent, at the annual fixed rental rate set forth in the Reference Page, which shall be payable in equal monthly installments of Fixed Rent in advance on the first day of each and every calendar month during the Term, except that the first monthly
 installment of Fixed Rent shall be payable by Tenant upon execution of this Lease; and

 

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(B)    additional rent (“Additional Rent”) consisting of all other sums of money (including, without limitation, any Tenant’s Operating Payment and any Tenant’s Tax Payment) as shall become due from and be payable by Tenant hereunder (for default in the
 payment of which Landlord shall have the same remedies as for a default in the payment of Fixed Rent).

Section 2.3    If the Commencement Date is other than the first day of a calendar month, Fixed Rent for such month shall be prorated on a per diem basis.

Section 2.4    If prior to the Commencement Date, Tenant shall occupy any portion of the Premises for the performance of work in the Premises or otherwise, Tenant shall, commencing as of the date of such occupancy, pay Landlord’s charges for (i) electricity, as reflected on
 the meters described in Article 30, and (ii) such items for which Tenant is separately billed hereunder, including, without limitation, overtime use of freight elevator and HVAC service and extra cleaning services. Such charges and items shall be payable to Landlord on demand.

Section 2.5    Tenant shall pay the Fixed Rent and Additional Rent when due without abatement, deduction, counterclaim, setoff or defense for any reason whatsoever, except said abatement as may be occasioned by the occurrence of any event permitting an abatement of
 Fixed Rent and Tenant’s Tax Payment and Tenant’s Operating Payment, as specifically set forth in this Lease.

ARTICLE 3

TENANT’S TAX PAYMENT

Section 3.1    For the purposes of this Article 3 and other provisions of this Lease:

(A)    The term “Taxes” shall mean (i) the real estate taxes, assessments and special assessments imposed upon the Project (whether or not comprised of one (1) or more tax lots) by any federal, state, municipal or other governments or governmental bodies or
 authorities, and (ii) any expenses incurred by Landlord in contesting such taxes or assessments and/or the assessed value of the Improvements and/or the Land, which expenses shall be allocated to the Tax Year to which such expenses relate. If at any time during the Term the methods of
 taxation prevailing on the date hereof shall be altered so that in lieu of, or as an addition to or as a substitute for, the whole or any part of such real estate taxes, assessments and special assessments now imposed on real estate there shall be levied, assessed or imposed (x) a tax, assessment,
 levy, imposition, license fee or charge wholly or partially as a capital levy or otherwise on the rents received therefrom, or (y) any other such additional or substitute tax, assessment, levy, imposition or charge, then all such taxes, assessments, levies, impositions, fees or charges or the
 part thereof so measured or based shall be deemed to be included within the term “Taxes” for the purposes hereof.

(B)    The term “Tax Year” shall mean the period of 12 calendar months beginning on January 1 of the year in which the Term commences, and each succeeding 12-month period thereafter.

 

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Section 3.2    Any Taxes for a real estate fiscal tax year, a part of which is included within a particular Tax Year and a part of which is not so included, shall be apportioned on the basis of the number of days in the real estate fiscal tax year included in the particular Tax Year
 for the purpose of making the computations under Section 3.3.

Section 3.3    For each Tax Year, any part of which shall occur during the Term, Tenant shall pay to Landlord an amount (prorated to the extent provided in Section 3.10, if applicable) (herein called “Tenant’s Tax Payment”) equal to Tenant’s Tax Proportionate Share of the
 Taxes for such Tax Year. Tenant’s Tax Payment shall be paid by Tenant to Landlord in twelve (12) equal monthly installments (subject to the further provisions of this Section 3.3), the first of which shall be due within ten (10) days after receipt of a Landlord’s Tax Statement, regardless
 of whether such Landlord’s Tax Statement is received prior to, on or after the first day of such Tax Year and the remaining installments shall be due on the first day of each month thereafter. Landlord shall bill (herein called “Landlord’s Tax Statement”) Tenant for any Tenant’s Tax
 Payment installment(s) payable by Tenant pursuant to this Article, such bill to set forth in reasonable detail the computation of the Tax Payment and the particular installment(s) thereof being billed. In the event of any increase in the Taxes for any Tax Year, whether during or after such
 Tax Year, or any decrease in the Taxes during such Tax Year, the Tax Payment for such Tax Year shall be appropriately adjusted and paid or refunded, as the case may be, in accordance therewith. If, during the Term, Taxes are required to be paid (either to the appropriate taxing
 authorities or as tax escrow payments to the Lessor or the Mortgagee), in full or in quarterly or other installments on any other date or dates than as presently required, then Tenant’s Tax Payments shall be correspondingly accelerated or revised so that installments of Tenant’s Tax
 Payment are due at least thirty (30) days prior to the date payments are due to the taxing authorities, the Lessor or the Mortgagee.

Section 3.4    Only Landlord shall be eligible to institute tax reduction or other proceedings to reduce Taxes. If Landlord shall receive a refund of the Taxes for any Tax Year, Landlord shall either pay to Tenant, or permit Tenant to credit against subsequent payments under
 this Lease, Tenant’s Tax Proportionate Share of the net refund (after deducting from such total refund the costs and expenses, including, but not limited to, appraisal, accounting and legal fees of obtaining the same, to the extent that such costs and expenses were not included in the Taxes
 for such Tax Year); provided, however, such payment or credit to Tenant shall in no event exceed Tenant’s Tax Payment paid for such Tax Year. Any refund of Taxes payable to Tenant under this Section shall include interest, but only if and to the extent Landlord receives interest on
 such Tax refund from the taxing authority.

Section 3.5    Omitted.

Section 3.6    At any time and from time to time Landlord may, in its sole discretion, calculate Taxes based on the separate tax lot upon which the Building is then located or such multiple tax lots designed by Landlord in its sole discretion, provided the Building is then
 located on one or more of such multiple tax lots. Landlord intends to and shall have the right at any time to cause part or parts of the Land to become a separate tax lot or separate tax lots in connection with future development thereof, in which event, commencing on the date on which

 

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Taxes on such separate tax lot or lots are paid by a third party, Taxes shall no longer include the real estate taxes, assessments and special assessments imposed on such separate tax lot or lots.

Section 3.7    If any building is enlarged, demolished or removed from the Land or any new building is erected on the Land, the term “Tenant’s Tax Proportionate Share” shall mean the percentage that represents a fraction the numerator of which is the number of square feet
 of rentable area in the Premises and the denominator of which is the aggregate number of square feet of rentable area of all buildings then on the Land.

Section 3.8    Tenant shall pay to Landlord upon demand as Additional Rent any occupancy tax or rent tax now in effect or hereafter enacted, if payable by Landlord in the first instance or hereafter required to be paid by Landlord.

Section 3.9    Landlord’s failure to render any Landlord’s Statement with respect to any Tax Year shall not prejudice Landlord’s right thereafter to render a Landlord’s Statement with respect thereto or with respect to any subsequent Tax Year, nor shall the rendering of a
 Landlord’s Statement prejudice Landlord’s right thereafter to render a corrected Landlord’s Statement for that Tax Year. Nothing herein contained shall restrict Landlord from issuing a Landlord’s Statement at any time there is an increase in Taxes during any Tax Year or any time
 thereafter. The rights and obligations of Landlord and Tenant under the provisions of this Article 3 with respect to any Tenant’s Tax Payment shall survive the Expiration Date.

Section 3.10 If the Commencement Date shall occur other than on the first day of a Tax Year or a Tax Year ends after the expiration or termination of this Lease, any Additional Rent in respect thereof payable under this Article shall be equitably prorated to correspond to that
 portion of the Tax Year occurring within the Term.

ARTICLE 4

TENANT’S OPERATING PAYMENT

Section 4.1    For the purposes of this Article 4 and other provisions of this Lease:

(A)    The term “Operating Expenses” shall mean all expenses paid or incurred by Landlord or on Landlord’s behalf in respect of the repair, maintenance and operation of the Core Campus, including, without limitation, all expenses paid or incurred as a result of
 Landlord complying with its obligations under this Lease. Operating Expenses shall include, without limitation, (i) salaries, wages, medical, surgical, union and general welfare benefits (including, without limitation, group life insurance and pension and welfare payments and
 contributions and all other fringe benefits paid to, for or with respect to all persons (whether employees of Landlord or its managing agent) engaged in the repair, operation and maintenance of the Core Campus (excluding employees above the level of Project Manager) ; (ii) payroll taxes,
 workers’ compensation, uniforms, dry cleaning, and related expenses for such persons; (iii) the cost of all charges for gas, steam, electricity, heat, ventilation, air-conditioning, water and other utilities furnished to the buildings within the Core Campus (including, without limitation, the
 common areas thereof) together with any taxes on such utilities (excluding however, the cost of electricity,

 

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heat, ventilating and air-conditioning described in clauses (9) and (10) of this definition); (iv) the cost of painting the common areas of the Project; (v) charges for telephone service for the management of the Core Campus; (vi) financial expenses incurred in connection with the operation
 of the Core Campus, such as insurance premiums (including, without limitation, liability insurance, fire and casualty insurance, rent insurance and any other insurance), reasonable attorneys’ fees and disbursements (exclusive of any such fees and disbursements incurred in applying for
 any reduction of Taxes or in connection with the leasing of space in the Core Campus or the enforcement of leases or in any way related to obtaining financing for the Project), auditing, accounting and other professional fees and expenses, association dues and any other ordinary and
 customary financial expenses incurred in connection with the operation of the Core Campus; (vii) the cost of purchases and rentals of all supplies (including, without limitation, building and cleaning supplies), tools (including, without limitation, hand tools), materials and equipment
 (both movable and immovable), and replacements for tools and equipment used in the operation, maintenance, and repair of the Core Campus and sales and other taxes thereon; (viii) charges of independent contractors (including, without limitation, for window and other cleaning and
 janitorial and security services); (ix) the cost of repairs and replacements made by Landlord; (x) the cost of alterations and improvements to the Core Campus made by reason of Requirements not in effect on the date hereof; (xi) payments under service contracts (including, without
 limitation, for window and other cleaning and janitorial and security services); (xii) management fees but not to exceed 4% of the aggregate rents, additional rents, and other charges payable to Landlord by tenants of the Core Campus; provided that if Landlord or an affiliate of Landlord
 is the managing agent, then a sum equal to 4% of the aggregate rents, additional rents and other charges payable to Landlord by tenants in the Core Campus; (xiii) the reasonable costs of operating an on-site management office, including, without limitation, the fair market rental value
 thereof; and (xiv) all other charges properly allocable to the repair, operation and maintenance of the Core Campus in accordance with generally accepted accounting principles; excluding, however, (1) depreciation, (2) interest on and amortization of debts, (3) ground rent, (4) leasehold
 improvements made for existing or future tenants of the Core Campus, (5) brokerage commissions, (6) refinancing costs, (7) costs and expenses in connection with the expansion of buildings or the construction of new buildings, (8) Taxes, and (9) the cost of Basic Electric and HVAC
 Electric (as such terms are defined in Section 30.1) furnished to the Premises or to other tenants of the Core Campus and (10) the cost of producing and furnishing steam and chilled water to provide heat, ventilating and air-conditioning furnished to the Premises or to other tenants of the
 Core Campus (11) costs paid or reimbursed directly by Tenant or another tenant in the Project (as distinguished from costs that are passed along to other tenants by virtue of provisions in their leases, analogous to this Article
 4, which require them to pay a proportionate share of operating
 costs or increases therein), and (12) capital improvements that do not qualify under clause (x) above and are not either (a) of a type which will reduce Operating Expenses or (b) reasonably required to maintain the condition of the Project in substantially the condition that it is as of the
 date hereof. If the capital expenditure is of a type which will reduce Operating Expenses, and does not qualify under the foregoing clause 12(b), then the amount of such expenditure will not exceed the amount of Operating Expense savings achieved. The cost of any capital improvement
 (excluding any new buildings or expansions of buildings) or machinery or equipment shall be included in Operating Expenses for the Operating Year in which such improvement was made or machinery or equipment was purchased, provided that to the extent the cost of such capital
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machinery or equipment is required to be capitalized for federal income tax purposes, such cost shall be amortized on a straight-line basis over the useful life thereof utilized for federal income tax purposes, and the annual amortization of such capital improvement or machinery or
 equipment, together with interest on the unamortized balance of such cost at the Applicable Rate, shall be included in Operating Expenses. Any cost or expense shall be included in Operating Expenses for any Operating Year no more than once, notwithstanding that such cost or expense
 may fall under more than one of the categories listed above. Landlord may use related or affiliated entities to provide services or furnish materials for the Core Campus provided that the rates or fees charged by such entities are competitive with those charged by unrelated or unaffiliated
 entities for the same services or materials, unless a fee or rate is specified in this Lease, in which event such fee or rate shall prevail. If during any Operating Year the tenant or occupant of any space in the Core Campus undertook to perform work or services therein in lieu of having
 Landlord perform the same and the cost thereof would have been included in Operating Expenses if done by Landlord, then, in any such event(s), the Operating Expenses for such Operating Year shall include the amount that would have been incurred if Landlord had performed such
 work or services, as the case may be, to the extent necessary only to allow Landlord to collect in full Landlord’s actual cost for performing such work or service for the remaining tenants of the Project. If less than all of the rentable area of the Core Campus is occupied by tenants at any
 time during any Operating Year, the Operating Expenses for such Operating Year shall be deemed to be the amount that Operating Expenses would have been had all of such rentable area been 100% occupied throughout such Operating Year. The provisions of the prior sentence with
 respect to adjustments of Operating Expenses for vacancy, shall apply only to Operating Expenses which are variable and which increase in the same relationship to the increase in occupancy in the Building and shall not apply to any Operating Expenses which do not vary with the level
 of occupancy in the Building. Operating Expenses shall be calculated on the accrual basis of accounting. With respect to any expenses paid or incurred by Landlord for the repair, maintenance and operation of the Core Campus and other buildings on the Land not comprising the Core
 Campus, Landlord shall equitably allocate, using good accounting principals, said expenses between the Core Campus and such other buildings. Notwithstanding the foregoing, Operating Expenses shall not include (i) expenditures for which Landlord is reimbursed from any insurance
 carrier, Tenant (except pursuant to Tenant’s obligation to pay its Proportionate Share of Operating Expenses) or other source or (ii) franchise taxes and income taxes.

(B)    The term “Landlord’s Operating Statement” shall mean a written statement prepared by Landlord or its agent, setting forth Landlord’s computation of the sum payable by Tenant under this Article for a specified Operating Year.

Section 4.2    For each Operating Year, any part of which occurs during the Term, Tenant shall pay to Landlord an amount (prorated to the extent provided in Section 4.6, if applicable) (herein called “Tenant’s Operating Payment”) equal to Tenant’s Operating Proportionate
 Share of the Operating Expenses for such Operating Year. Said payments shall be made as provided in Section 4.3.

Section 4.3    Landlord may furnish to Tenant, prior to the commencement of each Operating Year (or, in the case of the Operating Year in which the Term commences, prior to the

 

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Commencement Date), a written statement setting forth Landlord’s estimate of the Operating Payment for such Operating Year. Tenant shall pay to Landlord on the first day of each month during such Operating Year (or the portion thereof subsequent to the Commencement Date, as the
 case may be) an amount equal to one-twelfth of Landlord’s estimate of the Operating Payment for such Operating Year. If, however, Landlord shall furnish any such estimate for an Operating Year subsequent to the commencement thereof, then (a) until the first day of the month
 following the month in which such estimate is furnished to Tenant, Tenant shall pay to Landlord on the first day of each month an amount equal to the monthly sum payable by Tenant to Landlord under this Section in respect of the last month of the preceding Operating Year; (b) after
 such estimate is furnished to Tenant or included in or together with such estimate, Landlord shall give notice to Tenant stating whether the installments of the Operating Payment previously made for such Operating Year were greater or less than the installments of the Operating Payment
 to be made for such Operating Year in accordance with such estimate, and (i) if there shall be a deficiency, Tenant shall pay to Landlord the amount thereof within 10 days after demand therefor, or (ii) if there shall have been an overpayment, Landlord shall promptly either refund to
 Tenant the amount thereof or permit Tenant to credit the amount thereof against subsequent payments under this Article or Article 4; and (c) on the first day of the month following the month in which such estimate is furnished to Tenant, and monthly thereafter throughout the remainder
 of such Operating Year, Tenant shall pay to Landlord an amount equal to one-twelfth of the Operating Payment shown on such estimate. Landlord may, at any time or from time to time during each Operating Year, furnish to Tenant a revised statement of Landlord’s estimate of the
 Operating Payment for such Operating Year; and in such case, the Operating Payment for such Operating Year shall be adjusted and paid or refunded, as the case may be, substantially in the same manner as provided in the preceding sentence.

Section 4.4    Within 120 days after the end of each Operating Year Landlord shall furnish to Tenant Landlord’s Operating Statement for such Operating Year. If Landlord’s Operating Statement shows that the sums paid by Tenant under Section 4.3 exceeded the Operating
 Payment to be paid by Tenant for such Operating Year, Landlord shall promptly either refund to Tenant the amount of such excess or permit Tenant to credit the amount of such excess against subsequent payments under this Article or Article 3; and if Landlord’s Operating Statement for
 such Operating Year shows that the sums so paid by Tenant were less than the Operating Payment to be paid by Tenant for such Operating Year, Tenant shall pay to Landlord the amount of such deficiency within 10 day’s after demand therefor.

Section 4.5    Tenant, upon notice given within 90 days after any Landlord’s Operating Statement is sent to Tenant, may elect to have an Approved Examiner examine such of Landlord’s books and records as are directly relevant to the Landlord’s Operating Statement in
 question. Such Approved Examiner shall complete its examination of such books and records within a reasonable period of time after Tenant’s notice of examination is given to Landlord (but in no event longer than 90 days). An “Approved Examiner” shall mean an independent
 certified public accountant or accountants (who may be an employee of Tenant) which is not being compensated by Tenant, in whole or in part, on a contingency basis provided that such Approved Examiner is not and has not during the Term been affiliated with, a shareholder in, an
 officer, director, partner, or employee of, any Manager during the Term or the Manager named in this Lease. Tenant recognizes the confidential nature of Landlord’s books and records and agrees

 

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that information obtained by it or
    an Approved Examiner during any examination (including any compromise, settlement
    or adjustment relating to the results of such examination) shall be maintained
    in strict confidence by Tenant and such Approved Examiner. As a condition
    precedent  to Tenant’s exercise of its right to examine Landlord’s
    books and records, Tenant shall deliver to Landlord a confidentiality agreement,
    reasonably satisfactory to Landlord, from the Approved Examiner to the same
    effect as Tenant’s agreement contained in the preceding sentence. If,
     after such examination, such Approved Examiner shall dispute such Landlord’s
     Operating Statement, either party may refer the decision of the issues raised
     to a reputable independent firm of certified public accountants which has
     not performed services valued at $25,000 or more for  either party hereunder
     in the most recent three year period, selected by Landlord and approved
     by Tenant, which approval shall not be unreasonably withheld or delayed,
     and the decision of such accountants shall be conclusively binding upon
     the parties. The fees and expenses involved
 in resolving such dispute shall be borne by the unsuccessful party (and if both
     parties are partially unsuccessful, the accountants shall apportion the
     fees and expenses between the parties based upon the degree of success of
     each party). If Tenant shall not give such notice within such 90-day period,
     then the Operating Statement as furnished by Landlord shall be conclusive
     and binding upon Tenant. Tenant, pending the resolution of any contest shall
     continue to pay all sums as determined to be due in the first instance by
     Landlord’s Operating Statement and upon the
 resolution of such contest, suitable adjustment shall be made in accordance
     therewith with appropriate refund to be made by Landlord to Tenant (or credit
     allowed Tenant against the Fixed Rent and Additional Rent becoming due).
     If it is determined that Landlord, during an Operating  Year, overcharged
     Tenant for Operating Expenses by an amount that exceeds four (4%) percent
     of Tenant’s total Operating Payment for such Operating Year, Landlord
     shall reimburse Tenant for the reasonable cost incurred by Tenant in performing
     the audit of Landlord’s books and
 records.

Section 4.6    If the Commencement Date shall occur other than on the first day of an Operating Year or an Operating Year ends after the expiration or termination of this Lease, any Additional Rent in respect thereof payable under this Article shall be equitably prorated to
 correspond to that portion of the Operating Year occurring within the Term.

Section 4.7    If any building comprising the Core Campus is enlarged, demolished or removed from the Core Campus, or any building or the Land is added to the Core Campus (which Landlord may do in its sole and absolute discretion), the term “Tenant’s Operating
 Proportionate Share” shall be adjusted to mean the percentage that represents a fraction the numerator of which is the number of square feet of rentable area in the Premises and the denominator of which is the aggregate number of square feet of rentable area of all buildings then
 comprising the Core Campus.

Section 4.8    Landlord’s failure to render any Landlord’s Statement with respect to any Operating Year shall not prejudice Landlord’s right thereafter to render a Landlord’s Statement with respect thereto or with respect to any subsequent Operating Year, nor shall the
 rendering of a Landlord’s Statement prejudice Landlord’s right thereafter to render a corrected Landlord’s Statement for that Operating Year. Nothing herein contained shall restrict Landlord from issuing a Landlord’s Statement at any time there is an increase in Operating Expenses
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Operating Year or any time thereafter. All rights and obligations of Landlord and Tenant under the provisions of this Article 4 shall survive the Expiration Date.

ARTICLE 5

USE AND OCCUPANCY

Section 5.1    Tenant shall use and occupy the Premises for the Permitted Use and for no other purpose. Landlord acknowledges and agrees that Tenant’s use of the Premises will include the use of a bio-reactor.

Section 5.2    Tenant shall not use the Premises or any part thereof, or permit the Premises or any part thereof to be used, (1) for the business of photographic, multilith or multigraph reproductions or offset printing (other than those which are ancillary to an otherwise
 Permitted Use), (2) for an off-the-street retail commercial banking, thrift institution, loan company, trust company, depository or safe deposit business accepting deposits from the general public, (3) for the off-the-street retail sale of travelers checks, money orders, drafts, foreign
 exchange or letters of credit or for the receipt of money for transmission, (4) by the United States government, the City or State of New York, any foreign government, the United Nations or any agency or department of any of the foregoing having or asserting sovereign immunity, (5) for
 the preparation, dispensing or consumption of food or beverages in any manner whatsoever, except for the preparation, dispensing and consumption of food by Tenant’s employees who work in the Premises and not for the sale of food to any Persons other than such employees, (6) as an
 employment agency, day-care facility, labor union, school, or vocational training center (except for the training of employees of Tenant intended to be employed at the Premises), (7) as a barber shop, beauty salon or manicure shop, (8) omitted, (9) as offices of any public utility
 company, (10) for data processing activities (other than those which are ancillary to an otherwise Permitted Use), (11) medical offices or a medical clinic, (12) for clerical support services or offices of public stenographers or typists (other than those which are ancillary to an otherwise
 Permitted Use), (13) as reservation centers for airlines or travel agencies, (14) for retail or manufacturing use (except for manufacturing as permitted in by the Permitted Use), (15) as studios for radio, television or other media or (16) for the production, testing, use, or disposal of any
 toxic chemicals. Furthermore, the Premises shall not be used for any purpose that would, in Landlord’s reasonable judgment, tend to lower the first-class character of the Building, create unreasonable or excessive elevator or floor loads, violate the certificate of occupancy of the Building,
 impair or interfere with any of the Building operations or the proper and economic heating, air-conditioning, cleaning or any other services of the Building, interfere with the use of the other areas of the Building by any other tenants, or impair the appearance of the Building.
 Notwithstanding clause (16) of the immediately preceding sentence, Tenant may use the Premises to produce, test or use those toxic chemicals which are essential or incidental to the Tenant’s normal business operations, consistent with, and customary for, the operation of a non-military,
 commercial laboratory operated by Tenant and expressly permitted under all applicable Requirements and, if required by any Requirements, a current and valid permit or certificate issued by the Government Authority. If the Premises is used as set forth in the immediately proceeding
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toxic chemicals: (a) use the highest standard of care in all activities involving toxic chemicals; (b) arrange the Premises in a manner to allow for adequate space and orderly placement of all toxic chemicals and equipment used in connection with toxic chemicals; (c) separate or create a
 defined area within the Premises for the use, storage, production and/or testing of toxic chemicals; and (d) equip the Premises with the following items if necessary or prudent: (i) supplemental lighting and ventilation, (ii) air-supply and exhaust filters, (iii) a system for monitoring
 environmental conditions, and (iv) any other items that are necessary, prudent or required by any applicable Requirements.

Section 5.3    Landlord represents and warrants to Tenant that the current certificate of occupancy for the Building and insurance requirements applicable to the insurance maintained by Landlord on the Building permit the uses of the Premises that are Permitted Uses.

ARTICLE 6

ALTERATIONS

Section 6.1    (A)    Subject to obtaining Landlord’s prior written consent, which consent shall not be unreasonably withheld or delayed, Tenant may, from time to time, make any Alterations provided that: (i) the outside appearance of the Building shall not be affected; (ii)
 the strength of the Building shall not be affected; (iii) the structural parts of the Building shall not be adversely affected; (iv) no part of the Building outside of the Premises shall be affected; and (v) the proper functioning of the Building Systems shall not be adversely affected and the use
 of such systems by Tenant shall not be increased beyond Tenant’s allocable portion of the reserve capacity thereof, if any. If consent to any Alterations is not given, Landlord shall notify Tenant in sufficient detail to enable Tenant to amend its plans and specifications regarding such
 Alterations to comply with Landlord’s objections. Tenant may, without Landlord’s consent, but after written notice to Landlord, perform decorative Alterations such as painting and carpeting.

(B)    (1)    Prior to making any Alterations, Tenant shall, at Tenant’s expense, (i) submit to Landlord one set of mylar sepias and two sets of blue lines of final, stamped and detailed plans and specifications (including layout, architectural, electrical, mechanical
 and structural drawings) that comply with all Requirements for each proposed Alteration, and Tenant shall not commence any such Alteration without first obtaining Landlord’s approval of such plans and specifications which consent shall not be unreasonably withheld or delayed, (ii)
 obtain all permits, approvals and certificates required by any Government Authorities, and (iii) furnish to Landlord duplicate original policies of worker’s compensation insurance (covering all persons to be employed by Tenant, and Tenant’s contractors and subcontractors, in connection
 with such Alteration) and commercial general liability insurance (including premises operation, bodily injury, personal injury, death, independent contractors, products and completed operations, broad form contractual liability and broad form property damage coverages) in such form,
 with such companies, for such periods and in such amounts as Landlord may reasonably approve, naming Landlord and its agents, any Lessor and any Mortgagee, as additional insureds. If Landlord previously has provided Tenant or its architect with base building plans on a CADD disk,
 Tenant shall also submit Tenant’s plans and any changes thereto by disk. Upon completion of such

 

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Alteration, Tenant, at Tenant’s expense, shall obtain certificates of final approval of such Alterations required by any Government Authority and shall furnish Landlord with copies thereof, together with the “as-built” plans and specifications for such Alterations. All Alterations shall be
 made and performed in accordance with the plans and specifications therefor as approved by Landlord, all Requirements, the Tenant Criteria Manual for the Building and the Rules and Regulations. All materials and equipment to be incorporated in the Premises as a result of any
 Alterations shall be first quality and no such materials or equipment shall be subject to any lien, encumbrance, chattel mortgage, title retention or security agreement, provided that Tenant may finance its trade fixtures (and grant a security interest thereon to secure such financing) with an
 Institutional Lender if such financing is required by such lender to be paid in full during the Term. An “Institutional Lender” shall mean a savings bank, a savings and loan association, a commercial bank, a finance company (such as CIT or GECC), a trust company, which is organized
 under the laws of the United States or Canada and subject to the supervision of the Comptroller of the Currency, the Federal Reserve Board or a state banking superintendent or commissioners, an insurance company, an investment bank, a real estate mortgage investment conduit, a
 trustee in securitization, or any assignee of any thereof (which assignee must also be an Institutional Lender) organized and existing under the laws of the United States or Canada, a real estate investment trust sponsored by an Institutional Lender (which is not another real estate
 investment trust), or a union, federal, state, municipal or secular employee’s welfare, benefit, pension or retirement fund. Tenant shall deliver to Landlord, at the request of Landlord, which may be made at any time and from time to time, evidence of the outstanding amount of, and terms
 of, such financing and the identity of the lender thereof. In addition, no such Alteration for which the cost of labor and materials (as estimated by Landlord’s architect, engineer or contractor) is in excess of Five Hundred Thousand ($500,000) Dollars (excluding decorative items and
 Tenant’s trade fixtures), shall be undertaken prior to Tenant’s delivering to Landlord such security for timely lien-free completion thereof as is reasonably satisfactory to Landlord, and such Alteration shall be performed only under the supervision of a licensed architect satisfactory to
 Landlord. Notwithstanding the foregoing, Landlord shall not require Tenant to deliver a completion bond or other security in connection with Tenant’s initial Alterations. Notwithstanding the provisions of subsection B(1)(i) of this Section 6.1, with respect to any Alterations for which
 the cost of labor and materials (as estimated by Landlord’s architect or contractor) is less than One Hundred Thousand ($100,000) Dollars, either individually or in the aggregate with any other Alterations constructed in any six (6) month period, Tenant shall not be obligated to submit
 the detailed plans and specifications referred to in subsection (B)(1)(i) (unless required by any Requirements), but in lieu of such detailed plans and specifications, Tenant shall submit to Landlord five (5) sets of documentation sufficient adequately to inform Landlord and its architect and
 engineer of the Alterations proposed to be made by Tenant.

(2)    Landlord reserves the right to disapprove any plans and specifications in part, to reserve approval of items shown thereon pending its review and approval of other plans and specifications, and to condition its approval upon Tenant making
 revisions to the plans and specifications or supplying additional information. Tenant agrees that any review or approval by Landlord of any plans and/or specifications with respect to any Alteration is solely for Landlord’s benefit, and without any representation, warranty or liability
 whatsoever to Tenant or any other Person with respect to the adequacy, correctness or sufficiency or with respect to Requirements or otherwise. Landlord agrees to grant its approval

 

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or disapproval of any plans, or revisions to plans, within 10 days of the date such plans are delivered to Landlord in the form required by this Lease

(C)    Except as otherwise provided herein, Tenant shall be permitted to perform Alterations during Operating Hours, provided that such work does not materially interfere with or interrupt the operation and maintenance of the Building (as determined by
 Landlord) or unreasonably interfere with or interrupt the use and occupancy of the Building by any other tenants in the Building. Otherwise, Alterations shall be performed at such times and in such manner as Landlord may from time to time reasonably designate. All Alterations
 (including wiring and cabling from the raceways and conduits located in the Premises) shall become a part of the Building and shall be Landlord’s property from and after the installation thereof and may not be removed or changed without Landlord’s consent. Notwithstanding the
 foregoing, if, on or before the date Landlord approves Tenant’s plans and specifications (or other documentation) for Alterations (including wiring and cabling), Landlord notifies Tenant that Landlord is reserving the right to require Tenant to remove the same or any portion thereof, then
 Landlord prior to the Expiration Date, may require Tenant to remove all of such Alterations (including wiring and cabling) or any specified portion thereof and to repair and restore in a good and workmanlike manner to Building standard condition (reasonable wear and tear excepted)
 any damage to the Premises or the Building caused by such removal. All Tenant’s Property shall remain the property of Tenant and, on or before the Expiration Date, may be removed from the Premises by Tenant at Tenant’s option; provided, however, that Tenant shall repair and restore
 in a good and workmanlike manner any damage to the Premises or the Building caused by such removal. The provisions of this Section 6.1(C) shall survive the expiration or earlier termination of this Lease.

(D)    All Alterations shall be performed, at Tenant’s sole cost and expense, by contractors, subcontractors or mechanics approved by Landlord, such approval not to be unreasonably withheld or delayed. Prior to Tenant making any Alterations, Landlord or
 Manager, at Tenant’s request, shall furnish Tenant with a list of contractors, subcontractors and mechanics who may perform Alterations in or to the Premises on behalf of Tenant. If Tenant shall enter, within six months after Landlord shall furnish Tenant with such list, into a contract
 with any contractor set forth on the list, Tenant shall not be required to obtain Landlord’s consent to such contractor unless, prior to entering into a contract with such contractor or the commencement of work by the contractor, Landlord notifies Tenant that such contractor has been
 removed from the list.

(E)    (1)    Any mechanic’s lien filed against the Premises or the Real Property for work claimed to have been done for, or materials claimed to have been furnished to, Tenant shall be cancelled or discharged by Tenant, by payment or filing of the bond required
 by law, within twenty-five (25) days after such lien shall be filed, and Tenant shall indemnify and hold Landlord harmless from and against any and all costs, expenses, claims, losses or damages resulting therefrom by reason thereof.

(2)    If Tenant shall fail to discharge such mechanic’s lien within the aforesaid period, then, in addition to any other right or remedy of Landlord, Landlord may, but shall not be obligated to, discharge the same either by paying the amount claimed to be
 due or by procuring the discharge of such lien by deposit in court or bonding, and in any such event,

 

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Landlord shall be entitled, if Landlord so elects, to compel the prosecution of an action for the foreclosure of such mechanic’s lien by the lienor and to pay the amount of the judgment, if any, in favor of the lienor, with interest, costs and allowances.

(3)    Any amount paid by Landlord for any of the aforesaid charges and for all expenses of Landlord (including, but not limited to, attorneys’ fees and disbursements) incurred in defending any such action, discharging said lien or in procuring the
 discharge of said lien, with interest on all such amounts at the maximum legal rate of interest then chargeable to Tenant from the date of payment, shall be repaid by Tenant within ten (10) days after written demand therefor, and all amounts so repayable, together with such interest, shall
 be considered Additional Rent.

Section 6.2    Tenant shall reimburse Landlord, within five Business Days after demand therefor, for any out-of-pocket expense incurred by Landlord for reviewing the plans and specifications for any Alterations or inspecting the progress of completion of the same.

Section 6.3    Tenant shall furnish to Landlord copies of records of all Alterations and of the cost thereof within fifteen (15) days after request by Landlord after the completion of such Alterations.

Section 6.4    Tenant shall not, at any time prior to or during the Term, directly or indirectly employ, or permit the employment of, any contractor, mechanic or laborer in the Premises, whether in connection with any Alteration or otherwise, if such employment would
 interfere or cause any conflict with other contractors, mechanics or laborers engaged in the construction, maintenance or operation of the Building or the Project by Landlord, Tenant or others, or of any other property owned by Landlord. In the event of any such interference or conflict,
 Tenant, upon demand of Landlord, shall use best efforts to cause all contractors, mechanics or laborers causing such interference or conflict to leave the Building immediately.

ARTICLE 7

REPAIRS; FLOOR LOAD

Section 7.1    Tenant, at Tenant’s sole cost and expense, shall take good care of the Premises and the fixtures, equipment and appurtenances therein (including without limitation, any restrooms within the Premises) and make all repairs thereto as and when needed to preserve
 them in good working order and condition, except for (a) reasonable wear and tear, (b) obsolescence and (c) damage for which Tenant is not responsible pursuant to the provisions of Article 13. Except as otherwise provided in this Section 7.1, Tenant shall not be obligated to repair any
 Building Systems. The design and decoration of the elevator areas of each floor of the Premises and the public corridors of any floor of the Premises occupied by more than one (1) occupant shall be under the sole control of Landlord. Notwithstanding any provision contained in this
 Lease to the contrary, all damage or injury to the Premises, and all damage or injury to any other part of the Building, or to its fixtures, equipment and appurtenances (including Building Systems), whether requiring structural or non-structural repairs, caused by the moving of Tenant’s
 Property or caused by or resulting from any act or omission of, or Alterations made

 

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by, Tenant or Persons Within Tenant’s
    Control, shall be repaired by Tenant, at Tenant’s sole cost and expense,
    to the reasonable satisfaction of Landlord (if the required repairs are non-structural
    in nature and do not affect any Building Systems), or by Landlord at Tenant’s
    sole cost and  expense (if the required repairs are structural in nature
    or affect any Building Systems). All of the aforesaid repairs shall be performed
    in a manner and with materials and design of first class and quality consistent
    with first-class office buildings in Westchester County and shall be made

 in accordance with the provisions of Article 6. If Tenant shall fail,
 after ten (10) days notice (or such shorter period as may be required because
 of an emergency), to proceed with due diligence to make repairs required to
 be made by Tenant, the same may be made by Landlord, at the  expense of Tenant,
 and the expenses thereof incurred by Landlord, with interest thereon at the
 Applicable Rate, shall be paid to Landlord, as Additional Rent, within ten (10)
 days after rendition of a bill or statement therefor. Tenant shall give Landlord
 prompt notice of any defective
 condition in any Building Systems located in, servicing or passing through the
 Premises upon Tenant becoming aware of same.

Section 7.2    Tenant shall not place a load upon any floor of the Premises which exceeds the load which such floor was designed to carry and which is allowed by law. If Tenant is moving or locating any safe, machinery, equipment, freight, bulky matter or fixture which
 requires special handling (as determined by Landlord), Tenant shall employ only persons holding a Master Rigger’s license to do said work. All work in connection therewith shall comply with the Requirements, and shall be done during such hours as Landlord may reasonably designate.
 Business machines and mechanical equipment shall be placed and maintained by Tenant, at Tenant’s expense, in settings sufficient, in Landlord’s reasonable judgment, to absorb and prevent vibration, noise and annoyance.

Section 7.3    Landlord shall (subject to Tenant’s reimbursement obligation pursuant to Article 4) operate, maintain and make all necessary repairs (both structural and non-structural) to the Building Systems and the public portions of the Building, both exterior and interior,
 in conformance with standards applicable to first-class office buildings in Westchester County, except for those repairs for which Tenant is responsible pursuant to any other provision of this Lease. Landlord acknowledges that Tenant’s business involves manufacturing processes that are
 required to run uninterrupted for extended periods beyond customary business hours and that Tenant will incur substantial additional cost and expense if such manufacturing “runs” are interrupted. Landlord shall use reasonable efforts to minimize interference with Tenant’s use and
 occupancy of the Premises in making any repairs, alterations, additions or improvements and shall, except in the case of an emergency, attempt to coordinate with Tenant in making any repairs, alterations, additions or improvements so as to attempt to minimize any interference with
 Tenant’s use and occupancy of the Premises; provided, however, that Landlord shall have no obligation to employ contractors or labor at so-called overtime or other premium pay rates or to incur any other overtime costs in connection with such repairs, alterations, additions or
 improvements. Notwithstanding the foregoing, if Tenant shall so request, Landlord shall employ contractors or labor at so-called overtime or other premium pay rates or incur other overtime costs in making such repairs, alterations, additions or improvements, provided Tenant shall pay
 to Landlord, as Additional Rent, within ten (10) days after demand therefor, an amount equal to the excess costs incurred by Landlord by reason of compliance with Tenant’s request. Except as expressly provided in this Lease, there shall be no allowance to Tenant for a diminution of
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value and no liability on the part of Landlord by reason of inconvenience, annoyance or injury to business arising from Landlord, Tenant or others making, or failing to make, any repairs, alterations, additions or improvements in or to any portion of the Building or the Premises, or its
 fixtures, appurtenances or equipment.

ARTICLE 8

WINDOW CLEANING

Section 8.1    Tenant shall not clean, nor require, permit, suffer or allow any window in the Premises to be cleaned, from the outside in violation of Section 202 of the Labor Law, or any other applicable law, or of any other board or body having jurisdiction.

ARTICLE 9

REQUIREMENTS OF LAW

Section 9.1    Tenant shall not do, and shall not permit Persons Within Tenant’s Control to do, any act or thing in or upon the Premises or the Building which will invalidate or be in conflict with the certificate of occupancy for the Premises or the Building or violate any
 Requirements. Tenant shall, at Tenant’s sole cost and expense, take all action, including any required Alterations necessary to comply with all Requirements (including, but not limited to, applicable terms of the Americans With Disabilities Act of 1990 (the “ADA”), as modified and
 supplemented from time to time) which shall impose any violation, order or duty upon Landlord or Tenant arising from, or in connection with, the Premises, Tenant’s occupancy, use or manner of use of the Premises (including, without limitation, any occupancy, use or manner of use
 that constitutes a “place of public accommodation” under the ADA), or any installations in the Premises, or required by reason of a breach of any of Tenant’s covenants or agreements under this Lease, whether or not such Requirements shall now be in effect or hereafter enacted or
 issued, and whether or not any work required shall be ordinary or extraordinary or foreseen or unforeseen at the date hereof. Notwithstanding the preceding sentence, Tenant shall not be obligated to perform any Alterations necessary to comply with any Requirements, unless compliance
 shall be required by reason of (i) any cause or condition arising out of any Alterations or installations in the Premises (whether made by Tenant or by Landlord on behalf of Tenant), or (ii) Tenant’s particular use, manner of use or occupancy on behalf of Tenant of the Premises (as
 opposed to mere laboratory and office use), or (iii) any breach of any of Tenant’s covenants or agreements under this Lease, or (iv) any wrongful act or omission by Tenant or Persons Within Tenant’s Control, or (v) Tenant’s use or manner of use or occupancy of the Premises as a “place
 of public accommodation” within the meaning of the ADA, in which event Tenant’s obligation to perform any Alteration by reason of this clause (v) shall apply only to the Premises.

Section 9.2    Tenant covenants and agrees that Tenant shall, at Tenant’s sole cost and expense, comply at all times with all Requirements governing the use, generation, storage, treatment and/or disposal of any Hazardous Materials (as defined below), the presence of which

 

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results from or in connection with the act or omission of Tenant or Persons Within Tenant’s Control or the breach of this Lease by Tenant or Persons Within Tenant’s Control. The term “Hazardous Materials” shall mean any biologically or chemically active or other toxic or hazardous
 wastes, pollutants or substances, including, without limitation, asbestos, PCBs, petroleum products and by-products, substances defined or listed as “hazardous substances” or “toxic substances” or similarly identified in or pursuant to the Comprehensive Environmental Response,
 Compensation and Liability Act, 42 U.S.C. § 9601 et seq., and as hazardous wastes under the Resource Conservation and Recovery Act, 42 U.S.C. § 6010, et seq., any chemical substance or mixture regulated under the Toxic Substance Control Act of 1976, as amended, 15 U.S.C. §
 2601, et seq., any “toxic pollutant” under the Clean Water Act, 33 U.S.C. § 466 et seq., as amended, any hazardous air pollutant under the Clean Air Act, 42 U.S.C. § 7401 et seq., hazardous materials identified in or pursuant to the Hazardous Materials Transportation Act, 49 U.S.C. §
 1802, et seq., and any hazardous or toxic substances or pollutant regulated under any other Requirements. Tenant shall agree to execute, from time to time, at Landlord’s request, representations and the like concerning Tenant’s best knowledge and belief regarding the presence of
 Hazardous Materials in, on, under or about the Premises, the Building or the Land. Tenant shall indemnify and hold harmless all Indemnitees from and against any loss, cost, damage, liability or expense (including attorneys’ fees and disbursements) arising by reason of any clean up,
 removal, remediation, detoxification action, diminution in value of the Premises, damages for the loss or amenity of the Premises or any other activity required or recommended of any Indemnitees by any Government Authority by reason of the presence in or about the Building or the
 Premises of any Hazardous Materials, as a result of or in connection with the act or omission of Tenant or Persons Within Tenant’s Control or the breach of this Lease by Tenant or Persons Within Tenant’s Control. Without limiting the foregoing, if any Hazardous Materials attributable
 to Tenant or Persons Within Tenant’s Control, or the activities of any of them, are being used, stored, generated, or tested under or about the Premises in a manner that violates any Requirement, Tenant shall promptly take all actions, at its sole cost and expense, necessary to comply with
 all Requirements; provided that, except in emergency situations (in which case Notice shall be given to Landlord as soon as practicable), Landlord’s approval of such actions shall first be obtained, which approval shall not be unreasonably withheld or delayed. The foregoing covenants
 and indemnity shall survive the expiration or any termination of this Lease. Tenant shall, upon becoming aware of same, give prompt written notice to Landlord of (i) any condition in or near the Premises that shall pose a threat to the health, safety or welfare of humans, (ii) any
 proceeding or inquiry by any party (including any Government Authority) with respect to the presence of any Hazardous Materials in, from or about the Premises, (iii) all claims made or threatened by any third party (including any Government Authority) against Tenant or any party
 occupying the Premises relating to any loss or injury resulting from any Hazardous Materials in the Premises, and (iv) Tenant’s discovery of any occurrence or condition in the Premises, the Building or the Project that reasonably could cause the Building or the Project to be subject to
 any investigation or cleanup pursuant to any Requirement.

Section 9.3    If Tenant shall receive notice of any violation of, or defaults under, any Requirements, liens or other encumbrances applicable to the Premises, Tenant shall give prompt notice thereof to Landlord.

 

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Section 9.4    If any governmental license or permit shall be required for the proper and lawful conduct of Tenant’s business and if the failure to secure such license or permit would, in any way, adversely affect Landlord, the Building or the Project, then Tenant, at Tenant’s
 expense, shall promptly procure and thereafter maintain, submit for inspection by Landlord, and at all times comply with the terms and conditions of, each such license or permit.

Section 9.5    Tenant,
    at Tenant’s sole cost and expense and after notice to Landlord, may
    contest, by appropriate proceedings prosecuted diligently and in good faith,
    the legality or applicability of any Requirement affecting the Premises provided
    that: (a) neither Landlord  nor any Indemnitees shall be subject to criminal
    penalties, nor shall the Real Property or any part thereof be subject to
    being condemned or vacated, nor shall the certificate of occupancy for the
    Premises or the Building be suspended or threatened to be suspended, by reason
    of non-compliance or by reason of such contest; (b) before the commencement
    of such contest, if Landlord or any Indemnitees may be subject to any civil
    fines or penalties or if Landlord may be liable to any independent third
    party as a result of such non-compliance, then Tenant shall furnish
 to Landlord either (i) a bond of a surety company satisfactory to Landlord,
    in form and substance reasonably satisfactory to Landlord, and in an amount
    equal to one hundred twenty (120%) percent of Landlord’s reasonable
    estimate of the sum of (A) the cost of such compliance, (B) the  penalties
    or fines that may accrue by reason of such non-compliance (as reasonably
    estimated by Landlord) and (C) the amount of such liability to independent
    third parties, and shall indemnify Landlord (and any Indemnitees) against
    the cost of such compliance and liability resulting
 from or incurred in connection with such contest or non-compliance; or (ii)
    other security reasonably satisfactory in all respects to Landlord; (c) such
    non-compliance or contest shall not constitute or result in a violation (either
    with the giving of notice or the passage of time or both) of  the terms of
    any Mortgage or Superior Lease, or if such Superior Lease or Mortgage conditions
    such non-compliance or contest upon the taking of action or furnishing of
    security by Landlord, such action shall be taken or such security shall be
    furnished at the expense of Tenant; and (d)
 Tenant shall keep Landlord regularly advised as to the status of such proceedings.

Section 9.6    (A)    Landlord may, at its option and at Landlord’s expense, cause to be performed on or before the Commencement Date and provide to Tenant a phase I environmental assessment of the Premises, together with such additional reports and testing (including a
 phase II environmental assessment), if necessary in Landlord’s sole discretion from an environmental consultant selected by Landlord (the “Initial Environmental Audit”).

(B)    After Tenant has vacated the Premises in accordance with the terms and conditions of this Lease, but no later than 15 days after the expiration or sooner termination of this Lease, Landlord may obtain a phase I environmental assessment of the Premises,
 together with such additional reports and testing (including, a phase II environmental assessment) if necessary in Landlord’s sole discretion using the consultant who initially prepared the Initial Environmental Audit or, if that consultant is unavailable or if an Initial Environmental Audit
 had not been conducted, another licensed environmental consultant reasonably acceptable to Landlord, to determine the environmental status of the Premises as of the date of that environmental update (the “Environmental Update”). The cost of the foregoing environmental assessment
 shall be divided evenly between Landlord and Tenant, except if any Hazardous Material remediation work is required as a result of Tenant’s acts or omissions, Tenant shall bear

 

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the entire cost of such environmental assessment. Tenant shall pay to Landlord any amounts payable hereunder within 15 days after being billed therefor.     

(C)    Tenant’s obligations under Section 9.2 of this Lease shall also apply to any Hazardous Materials which are revealed by the Environmental Update (or any inspection by Landlord prior to Tenant’s delivery of the Premises to Landlord), but which were not
 revealed by the Initial Environmental Audit. This Paragraph 9.6 shall survive the expiration or sooner termination of this Lease.

Section 9.7    (A)    At any time prior to the Expiration Date or sooner termination of this Lease or to any assignment of this Lease or any subletting of any portion of the Premises, Landlord, in its sole discretion, may inspect or cause the inspection of the Premises for the
 purpose of determining whether or not Tenant is in compliance with this Article 9 and whether or not to conduct more detailed inspection, sampling and testing of the Premises to determine whether all Hazardous Materials are being used, stored, generated or tested in accordance with all
 Requirements.

(B)    If as a result of any inspection, sampling or testing, it is determined that there exists upon the Premises Hazardous Materials other than in compliance with this Lease and all Requirements, then, Tenant shall, at its sole cost and expense, immediately comply
 with the fifth sentence in Section 9.2 and all other Articles of this Lease as applicable and appropriate.

(C)    Tenant shall fully cooperate with Landlord in connection with any rules and regulations of Landlord regarding Tenant’s use, production or storage of Hazardous Materials upon the Premises including, but not limited to, promptly completing and returning to
 Landlord any questionnaires regarding Hazardous Materials.

(D)    All of Landlord’s costs in reviewing the inspection and sampling plan and test results and developing a plan for and monitoring the cleanup and site detoxification, shall be paid by Tenant, as Additional Rent, within twenty (20) days after receipt of an
 invoice therefor.

Section 9.8    Landlord represents and warrants to Tenant that, to Landlord’s actual knowledge, there is no asbestos in the Premises or the public areas of the Building, except for the possible presence of asbestos on certain pipes, which is either encapsulated or is not in friable
 condition. If it is hereafter determined that asbestos which is present in the Premises on the Commencement Date is friable and not disturbed by Alterations to be made by Tenant in accordance herewith, then, provided Tenant is not in default hereunder beyond applicable notice and
 grace and the need for removal or encapsulation of such asbestos does not arise as a result of the negligent or wrongful acts or omissions of Tenant or its agent, subtenant, employee, contractor or invitee, Landlord shall promptly at its expense, remove or (provided Tenant’s permitted
 Alterations will not be materially adversely affected thereby) encapsulate such asbestos in accordance with applicable Requirements. Landlord shall perform such work in a manner as to have the least practicable interference with Tenant’s use and operations in the Premises, recognizing
 Tenant’s sensitive laboratory work.

 

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ARTICLE 10

SUBORDINATION

Section 10.1    Subject to the provisions in Section 10.5 below, this Lease shall be subject and subordinate to each Superior Lease and to each Mortgage, whether made prior to or after the execution of this Lease, and to all renewals, extensions, supplements, amendments,
 modifications, consolidations and replacements thereof or thereto, substitutions therefor, and advances made thereunder. This clause shall be self-operative and no further agreement of subordination shall be required to make the interest of any Lessor or Mortgagee superior to the interest
 of Tenant hereunder. In confirmation of such subordination, however, Tenant shall promptly execute and deliver, at its own cost and expense, any document, in recordable form if requested, that Landlord, any Lessor or any Mortgagee may request to evidence such subordination; and if
 Tenant fails to execute, acknowledge or deliver any such document within ten (10) days after request therefor, Tenant hereby irrevocably constitutes and appoints Landlord as Tenant’s attorney-in-fact, coupled with an interest, to execute, acknowledge and deliver any such document for
 and on behalf of Tenant. Tenant shall not knowingly do anything that would constitute a default under any Superior Lease or Mortgage, or omit to do anything that Tenant is obligated to do under the terms of this Lease so as to cause Landlord to be in default thereunder. If, in connection
 with the financing of the Real Property, the Building or the interest of the lessee under any Superior Lease, or if, in connection with the entering into of a Superior Lease, any lending institution or Lessor, as the case may be, requests reasonable modifications of this Lease that do not
 increase rent or change the Term of this Lease, or materially and adversely affect the rights or obligations of Tenant under this Lease, Tenant shall make such modifications.

Section 10.2    If,
    at any time prior to the expiration of the Term, any Superior Lease shall
    terminate or shall be terminated for any reason, or any Mortgagee comes into
    possession of the Real Property or the Building or the estate created by
    any Superior Lease by receiver or otherwise, Tenant agrees, subject to the
    provisions in Section 10.5 below, at the election and upon demand of any
    owner of the Real Property or the Building, or of the Lessor, or of any Mortgagee
    in possession of the Real Property or the Building, to attorn, from time
    to time, to any such
 owner, Lessor or Mortgagee or any person acquiring the interest of Landlord
    as a result of any such termination, or as a result of a foreclosure of the
    Mortgage or the granting of a deed in lieu of foreclosure, upon the then
    executory terms and conditions of this Lease (except as provided below),
    for the remainder of the Term, provided that such owner, Lessor or Mortgagee,
    as the case may be, or receiver caused to be appointed by any of the foregoing,
    is then entitled to possession of the Premises. Provided that in the event
    of any conflict between the applicable Non-Disturbance Agreement (as hereinafter
    defined) and this Section 10.2, the applicable
    Non-Disturbance Agreement shall govern and control any such attornment shall
    be made upon the condition that no such owner, Lessor or Mortgagee shall
  be:

(1)    liable for any act or omission of any prior landlord (including, without limitation, the then defaulting landlord) although such owner, Lessor or Mortgagee shall be obligated to correct any conditions existing at the date of attornment which violate such party’s
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(2)    subject to any defense or offsets (except as expressly set forth in this Lease) which Tenant may have against any prior landlord (including, without limitation, the then defaulting landlord); or

(3)    bound by any payment of Rental which Tenant might have paid for more than the current month to any prior landlord (including, without limitation, the then defaulting landlord), except for refunds or credits of Taxes or Operating Expenses due to Tenant; or

(4)    bound by any obligation to make any payment to Tenant which was required to be made prior to the time such owner, Lessor or Mortgagee succeeded to any prior landlord’s interest; or

(5)    bound by any amendment, modification, surrender or termination of this Lease made without Lessor’s or Mortgagee’s prior written consent; or

(6)    bound by any obligation to perform any work or to make improvements to the Premises except for repairs and maintenance pursuant to the provisions of this Lease. The provisions of this Section 10.2 shall inure to the benefit of any such owner, Lessor or
 Mortgagee, shall apply notwithstanding that, as a matter of law, this Lease may terminate upon the termination of any such Superior Lease, and shall be self-operative upon any such demand, and no further agreement shall be required to give effect to said provisions. Subject to the
 provisions in Section 10.5 below, Tenant, however, upon demand of any such owner, Lessor or Mortgagee, shall execute, from time to time, agreements in confirmation of the foregoing provisions of this Section 10.2, satisfactory to any such owner, Lessor or Mortgagee, and
 acknowledging such attornment and setting forth the terms and conditions of its tenancy. Nothing contained in this Section 10.2 shall be construed to impair any right otherwise exercisable by any such owner, Lessor or Mortgagee.

Section 10.3    At any time and from time to time upon ten (10) days’ prior notice to Tenant by Landlord or a Lessor or Mortgagee (which ten (10) day period is not subject to any notice and cure periods otherwise provided in this Lease), Tenant shall, without charge, execute,
 acknowledge and deliver a statement in writing addressed to such party as Landlord, Lessor or Mortgagee, as the case may be, may designate, in form satisfactory to Landlord, Lessor or Mortgagee, as the case may be, certifying all or any of the following: (i) that this Lease is unmodified
 and in full force and effect (or if there have been modifications, that this Lease is in full force and effect as modified and stating the modifications); (ii) whether the Term has commenced and Fixed Rent and Additional Rent have become payable hereunder and, if so, the dates to which
 they have been paid; (iii) whether or not, to the best knowledge of the signer of such certificate, Landlord is in default in performance of any of the terms of this Lease and, if so, specifying each such Event of Default of which the signer may have knowledge; (iv) whether Tenant has
 accepted possession of the Premises; (v) whether Tenant has made any claim against Landlord under this Lease and, if so, the nature thereof and the dollar amount, if any, of such claim; (vi) either that Tenant does not know of any default in the performance of any provision of this Lease
 or specifying the details of any default of which Tenant may have knowledge and stating what action Tenant is taking or proposes to take with respect thereto; (vii) that, to the

 

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knowledge of Tenant, there are no proceedings pending or threatened against Tenant before or by any court or administrative agency which, if adversely decided, would materially and adversely affect the financial condition or operations of Tenant or, if any such proceedings are pending
 or threatened to the knowledge of Tenant, specifying and describing the same; and (viii) such further information with respect to this Lease or the Premises as Landlord may reasonably request or Lessor or Mortgagee may require; it being intended that any such statement delivered
 pursuant hereto may be relied upon by any prospective purchaser of the Real Property or any part thereof or of the interest of Landlord in any part thereof, by any Mortgagee or prospective Mortgagee, by any Lessor or prospective Lessor, by any tenant or prospective tenant of the Real
 Property or any part thereof, or by any prospective assignee of any Mortgage.

The failure of Tenant to execute, acknowledge and deliver to Landlord a statement in accordance with the provisions of this Section 10.3 within said ten (10) day period shall constitute an acknowledgment by Tenant, which may be relied on by any person who would be
 entitled to rely upon any such statement, that such statement as submitted by Landlord is true and correct.

Section 10.4    As long as any Superior Lease or Mortgage exists, Tenant shall not seek to terminate this Lease by reason of any act or omission of Landlord until Tenant has given written notice of such act or omission to all Lessors and Mortgagees at such addresses as may
 have been furnished to Tenant by such Lessors and Mortgagees and, if any such Lessor or Mortgagee, as the case may be, notifies Tenant within thirty (30) days following receipt of such notice of its intention to remedy such act or omission using diligent and continuous efforts, until a
 reasonable period of time shall have elapsed following the giving of such notice, during which period such Lessors and Mortgagees shall have the right, but not the obligation, to remedy such act or omission.

Section 10.5    (A)    As used in this Article 10, the term Non-Disturbance Agreement shall mean an agreement in recordable form that provides in substance that, so long as Tenant shall not then be in default in the performance of any of its obligations under this Lease
 beyond any period provided for herein for the cure of such default, Tenant’s possession of the Premises in accordance with this Lease shall not be disturbed by such person giving the non-disturbance agreement or any successor or purchaser at a foreclosure sale (as the case may be)
 which shall succeed to the rights of Landlord under this Lease. Such agreement shall be in such form as is customarily used by the Mortgagee or Lessor if it is an institutional lender. Tenant shall reimburse Landlord upon demand for any and all costs and expenses (including, without
 limitation, reasonable attorneys’ fees and disbursements) incurred or payable by Landlord in connection with obtaining each such non-disturbance agreement.

(B)    With respect to any Mortgage, the provisions of Section 10.1 of this Lease shall only operate to subject and subordinate this Lease to the Mortgage if the holder of the Mortgage shall furnish a Non-Disturbance Agreement to Tenant.

 

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ARTICLE 11

RULES AND REGULATIONS

Section 11.1    Tenant and Persons Within Tenant’s Control shall comply with the Rules and Regulations. Nothing contained in this Lease shall be construed to impose upon Landlord any duty or obligation to enforce the Rules and Regulations or the terms, covenants or
 conditions in any other lease against any other tenant, and Landlord shall not be liable to Tenant for violation of the same by any other tenant, its employees, agents, visitors or licensees. Landlord shall not discriminate against Tenant in enforcing the Rules and Regulations. In case of any
 conflict or inconsistency between the provisions of this Lease and of any of the Rules and Regulations as originally or as hereinafter adopted, the provisions of this Lease shall control.

ARTICLE 12

INSURANCE, PROPERTY LOSS OR DAMAGE; REIMBURSEMENT

Section 12.1    (A)    No Tenant shall entrust any property to any Building employee. Any Building employee to whom any property is entrusted by or on behalf of Tenant in violation of the foregoing prohibition shall be deemed to be acting as Tenant’s agent with respect to
 such property and neither Landlord nor its agents shall be liable for any damage to property of Tenant or of others entrusted to employees of the Building, nor for the loss of or damage to any property of Tenant by theft or otherwise. Landlord and Landlord’s agents shall not be liable for
 any damage to any of Tenant’s Property or for interruption of Tenant’s business caused by other tenants or persons in the Building. Landlord shall not be liable for any latent defect in the Premises or in the Building.

(B)    If at any time any windows of the Premises are temporarily closed, darkened or covered for any reason, including Landlord’s own acts if reasonably necessary in connection with the operation of the Project, or if any such windows are permanently closed,
 darkened or covered by reason of any Requirements, Landlord shall not be liable for any damage Tenant may sustain thereby, and Tenant shall not be entitled to any compensation therefor nor abatement of Fixed Rent or any other item of Rental, nor shall the same release Tenant from
 Tenant’s obligations hereunder nor constitute an eviction. Except in case of emergency, Landlord shall give Tenant reasonable prior written notice of any such closure or darkening.

(C)    Tenant shall give notice to Landlord promptly after Tenant learns of any accident, emergency, occurrence for which Landlord might be liable, fire or other casualty and all damages to or defects in the Premises or the Building for the repair of which Landlord
 might be responsible or which constitutes Landlord’s property. Such notice shall be given by telecopy or personal delivery to the address(es) of Landlord in effect for notice.

Section 12.2    Tenant shall not do or permit to be done any act or thing in or upon the Premises which will invalidate or be in conflict with the terms of the New York State standard policies of fire insurance and liability (hereinafter referred to as “Building Insurance”); and
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requirements of all insurance boards, and shall not do or permit anything to be done in or upon the Premises or bring or keep anything therein or use the Premises in a manner which increases the rate of premium for any of the Building Insurance over the rate in effect at the
 commencement of the Term of this Lease.

Section 12.3    If by reason of any failure of Tenant to comply with the provisions of this Lease, the rate of premium for Building Insurance or other insurance on the property and equipment of Landlord shall increase, Tenant shall reimburse Landlord for that part of the
 insurance premiums thereafter paid by Landlord which shall have been charged because of such failure by Tenant. Tenant shall make said reimbursement on the first day of the month following such payment by Landlord and receipt of notice thereof.

Section 12.4    (A)    At Tenant’s own cost and expense, Tenant shall obtain, maintain and keep in full force and effect during the Term commercial general liability insurance (without deductible) in a form approved in New York State (including broad form property
 damage coverages). The limits of liability shall be not less than Five Million and 00/100 ($5,000,000.00) Dollars per occurrence, which amount may be satisfied with a primary commercial general liability policy of not less than $1,000,000.00 and an excess (or “Umbrella”) liability
 policy affording coverage, at least as broad as that afforded by the primary commercial general liability policy, in an amount not less than $4,000,000.00. Landlord, the Manager, any Lessors and any Mortgagees shall be included as additional insureds in said policies and shall be
 protected against all liability arising in connection with this Lease. All said policies of insurance shall be written as “occurrence” policies. Whenever, in Landlord’s reasonable judgment, good business practice and changing conditions indicate a need for additional amounts or different
 types of insurance coverage, Tenant shall, within ten (10) days after Landlord’s request, obtain such insurance coverage, at Tenant’s expense.

(B)    Tenant, at Tenant’s sole cost and expense, shall maintain all-risk insurance, with deductibles in an amount reasonably satisfactory to Landlord, protecting and indemnifying Tenant against any and all damage to or loss of any Alterations and leasehold
 improvements, including any made by Landlord to prepare the Premises for Tenant’s occupancy and Tenant’s Property. All said policies shall cover the full replacement value of all Alterations, leasehold improvements and Tenant’s Property.

(C)    All policies of insurance shall be: (i) written as primary policy coverage and not contributing with or in excess of any coverage which Landlord or any Lessor may carry; and (ii) issued by reputable and independent insurance companies rated in Best’s
 Insurance Guide or any successor thereto (or, if there is none, an organization having a national reputation), as having a general policyholder rating of “A” and a financial rating of at least “10”, and which are licensed to do business in the State of New York or otherwise reasonably
 acceptable to Landlord. Tenant shall, not later than ten (10) Business Days prior to the Commencement Date, deliver to Landlord certificates the policies of insurance and shall thereafter furnish to Landlord, at least thirty (30) days prior to the expiration of any such policies and any
 renewal thereof, a certificate of the new policy in lieu thereof. Each of said policies shall also contain a provision whereby the insurer agrees not to cancel, fail to renew, diminish or materially modify said insurance policy(ies) without having given Landlord, the Manager and any Lessors
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Mortgagees at least thirty (30) days prior written notice thereof. Tenant shall promptly send to Landlord a copy of all notices sent to Tenant by Tenant’s insurer. Upon request from Landlord, tenant shall deliver copies of the policies of insurance for which certificates were delivered to
 Landlord.

(D)    Tenant shall pay all premiums and charges for all of said policies, and, if Tenant shall fail to make any payment when due or carry any such policy, Landlord may, but shall not be obligated to, make such payment or carry such policy, and the amount paid by
 Landlord, with interest thereon (at the Applicable Rate), shall be repaid to Landlord by Tenant on demand, and all such amounts so repayable, together with such interest, shall be deemed to constitute Additional Rent hereunder. Payment by Landlord of any such premium, or the carrying
 by Landlord of any such policy, shall not be deemed to waive or release the default of Tenant with respect thereto.

Section 12.5    (A)    Landlord shall cause each policy carried by Landlord insuring the Building against loss, damage or destruction by fire or other casualty, and Tenant shall cause each insurance policy carried by Tenant and insuring the Premises and Tenant’s Alterations,
 leasehold improvements and Tenant’s Property against loss, damage or destruction by fire or other casualty, to be written in a manner so as to provide that the insurance company waives all rights of recovery by way of subrogation against Landlord, Tenant and any tenant of space in the
 Building in connection with any loss or damage covered by any such policy. Neither party shall be liable to the other for the amount of such loss or damage which is in excess of the applicable deductible, if any, caused by fire or any of the risks enumerated in its policies, provided that
 such waiver was obtainable at the time of such loss or damage. However, if such waiver cannot be obtained, or shall be obtainable only by the payment of an additional premium charge above that which is charged by companies carrying such insurance without such waiver of
 subrogation, then the party undertaking to obtain such waiver shall notify the other party of such fact and such other party shall have a period of ten (10) days after the giving of such notice to agree in writing to pay such additional premium if such policy is obtainable at additional cost
 (in the case of Tenant, pro rata in proportion of Tenant’s rentable area to the total rentable area covered by such insurance); and if such other party does not so agree or the waiver shall not be obtainable, then the provisions of this Section 12.5 shall be null and void as to the risks covered
 by such policy for so long as either such waiver cannot be obtained or the party in whose favor a waiver of subrogation is desired shall refuse to pay the additional premium. If the release of either Landlord or Tenant, as set forth in the second sentence of this Section 12.5, shall
 contravene any law with respect to exculpatory agreements, the liability of the party in question shall be deemed not released, but no action or rights shall be sought or enforced against such party unless and until all rights and remedies against the other’s insurer are exhausted and the
 other party shall be unable to collect such insurance proceeds.

(B)    The waiver of subrogation referred to in Section 12.5(A) above shall extend to the agents and employees of each party (including, as to Landlord, the Manager), but only if and to the extent that such waiver can be obtained without additional charge (unless
 such party shall pay such charge). Nothing contained in this Section 12.5 shall be deemed to relieve either party from any duty imposed elsewhere in this Lease to repair, restore and rebuild.

 

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ARTICLE 13

DESTRUCTION BY FIRE OR OTHER CAUSE

Section 13.1    If the Premises or any part thereof shall be damaged by fire or other casualty, Tenant shall give prompt written notice thereof to Landlord. Landlord shall, subject to the provisions of Sections 13.2 and 13.3 below, proceed with reasonable diligence, after receipt
 of, and subject to obtaining, the net proceeds of insurance, to repair or cause to be repaired such damage at its expense, but such repair obligation shall be limited to the core and structural core and perimeter walls only, with access available to the Premises; and, if the Premises, or any
 part thereof, shall be rendered untenantable by reason of such damage and such damage shall not be due to the fault of Tenant or Persons Within Tenant’s Control, then the Fixed Rent and the Additional Rent payable pursuant to Articles 3 and 4, or an amount thereof apportioned
 according to the area of the Premises so rendered untenantable (if less than the entire Premises shall be so rendered untenantable), shall be abated for the period from the date of such damage to the date when the repair of such damage shall have been substantially completed. Tenant
 covenants and agrees to cooperate with Landlord and any Lessor or any Mortgagee in their efforts to collect insurance proceeds (including rent insurance proceeds) payable to such parties. Landlord shall not be liable for any delay which may arise by reason of adjustment of insurance on
 the part of Landlord and/or Tenant, or any cause beyond the control of Landlord or contractors employed by Landlord. Tenant shall, after Landlord shall have substantially completed its repair obligations, repair all damage to Tenant’s Property, Tenant’s Alterations and all leasehold
 improvements in the Premises.

Section 13.2    Landlord shall not be liable for any inconvenience or annoyance to Tenant or injury to the business of Tenant resulting in any way from damage from fire or other casualty or the repair thereof. Tenant understands that Landlord, in reliance upon Section 12.4,
 will not carry insurance of any kind on Tenant’s Property, Tenant’s Alterations and leasehold improvements, and that Landlord shall not be obligated to repair any damage thereto or replace the same.

Section 13.3    Notwithstanding anything to the contrary contained in Sections 13.1 and 13.2 above, if the Premises shall be materially (i.e., 30% or more) damaged or destroyed by fire or other casualty, or if the Building shall be so damaged or destroyed by fire or other
 casualty (whether or not the Premises are damaged or destroyed) that its repair or restoration requires the expenditure (as estimated by a reputable contractor or architect designated by Landlord) of more than 30% of the full insurable value of the Building immediately prior to the
 casualty, then in either such case Landlord may, in Landlord’s sole and absolute discretion, terminate this Lease and the term and estate hereby granted, by notifying Tenant in writing of such termination within ninety (90) days after the date of such damage. In the event that such a
 notice of termination shall be given, then this Lease and the term and estate hereby granted shall expire as of the date of termination stated in said notice with the same effect as if that were the Fixed Expiration Date, and the Fixed Rent and Additional Rent payable pursuant to Articles 3
 and 4 shall be apportioned as of such date. If the Premises shall be damaged or destroyed by fire or other casualty not caused by the negligence or wrongful act of Tenant, such that 30% or more of the Premises is rendered untenantable or reasonable means of access to the Premises is cut
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contractor or architect estimates that the Premises will not be substantially repaired or restored within one (1) year following such fire or other casualty, or (ii) the Premises are not substantially repaired and restored within one (1) year after the date of the fire or other casualty, or (iii)
 because of Landlord’s failure to commence such repair and restoration within six (6) months after such casualty, such repair and restoration will not be completed within such one (1) year period, then Tenant shall have the right to terminate this Lease by giving Landlord notice to such
 effect within 30 days after the date of such fire or casualty, if pursuant to clause (i), or the end of such six (6) month or one (1) year period, as the case may be, if pursuant to clause (ii) or (iii), in which event the Fixed Rent and Additional Rent shall be prorated and adjusted as of the date
 of termination.

Section 13.4    Except as may be provided in Section 12.5, nothing herein contained shall relieve Tenant from any liability to Landlord or to Landlord’s insurers in connection with any damage to the Premises or the Building by fire or other casualty if Tenant shall be legally
 liable in such respect.

Section 13.5    This Lease shall be considered an express agreement governing any case of damage to or destruction of the Building or any part thereof by fire or other casualty, and Section 227 of the Real Property Law of the State of New York providing for such a
 contingency in the absence of express agreement and any other law of like import now or hereafter in force, shall have no application in such case.

ARTICLE 14

EMINENT DOMAIN

Section 14.1    If the whole of the Building or the Premises is acquired or condemned for any public or quasi-public use or purpose, this Lease and the Term shall end as of the date of the vesting of title with the same effect as if said date were the Fixed Expiration Date. If
 only a part of the Building or the Land and not the entire Premises is so acquired or condemned then, (1) except as hereinafter provided in this Section 14.1, this Lease and the Term shall continue in effect but, if a part of the Premises is included in the part of the Building or the Land so
 acquired or condemned, from and after the date of the vesting of title, the Fixed Rent and the Additional Rent payable pursuant to Articles 3 and 4 shall be reduced in the proportion which the area of the part of the Premises so acquired or condemned bears to the total area of the Premises
 immediately prior to such acquisition or condemnation; (2) whether or not the Premises are affected thereby, Landlord, at Landlord’s option, may give to Tenant, within sixty (60) days next following the date upon which Landlord receives notice of vesting of title, a thirty (30) day notice
 of termination of this Lease; and (3) if the part of the Building or the Land so acquired or condemned contains more than twenty (20%) percent of the total area of the Premises immediately prior to such acquisition or condemnation and the remaining area of the Premises shall not be
 reasonably sufficient for Tenant to continue feasible operation of its business, or if, by reason of such acquisition or condemnation, Tenant no longer has access to the Premises, Tenant, at Tenant’s option, may give to Landlord, within sixty (60) days next following the date upon which
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this Lease. If any such thirty (30) day notice of termination is given, by Landlord or Tenant, this Lease and the Term shall come to an end and expire upon the expiration of said thirty (30) days with the same effect as if the date of expiration of said thirty (30) days were the Fixed
 Expiration Date. If a part of the Premises is so acquired or condemned and this Lease and the Term are not terminated pursuant to the foregoing provisions of this Section 14.1, Landlord, at Landlord’s cost and expense, shall restore that part of the Premises not so acquired or condemned
 to a self-contained rental unit, exclusive of Tenant’s Alterations, leasehold improvements and Tenant’s Property. In the event of any termination of this Lease and the Term pursuant to the provisions of this Section 14.1, the Fixed Rent shall be apportioned as of the date of sooner
 termination and any prepaid portion of the Fixed Rent or Additional Rent payable pursuant to Articles 3 and 4 for any period after such date shall be refunded by Landlord to Tenant.

Section 14.2    In the event of any such acquisition or condemnation of all or any part of the Real Property, Landlord shall be entitled to receive the entire award for any such acquisition or condemnation. Tenant shall have no claim against Landlord or the condemning
 authority for the value of any unexpired portion of the Term and Tenant hereby expressly assigns to Landlord all of its right in and to any such award. Nothing contained in this Section 14.2 shall be deemed to prevent Tenant from making a separate claim in any condemnation
 proceedings for the value of any Tenant’s Property and Tenant’s Alterations included in such taking, and for any moving expenses, so long as Landlord’s award is not reduced thereby.

Section 14.3    If the whole or any part of the Premises is acquired or condemned temporarily during the Term for any public or quasi-public use or purpose, the Term shall not be reduced or affected in any way and Tenant shall continue to pay in full all items of Rental
 payable by Tenant hereunder without reduction or abatement, and Tenant shall be entitled to receive for itself any award or payments for such use; provided, however, that if the acquisition or condemnation is for a period extending beyond the Term, such award or payment shall be
 apportioned between Landlord and Tenant as of the Expiration Date; provided, however, that the amount of any award or payment allowed or retained for restoration of the Premises shall remain the property of Landlord if this Lease expires prior to the restoration of the Premises.

ARTICLE 15

ASSIGNMENT, SUBLETTING, MORTGAGE, ETC.

Section 15.1    Tenant shall not, whether voluntarily, involuntarily, or by operation of law or otherwise (a) assign or otherwise transfer this Lease other than to an Affiliate of Tenant, or offer or advertise to do so, (b) sublet the Premises or any part thereof, or offer or advertise
 to do so, or allow the same to be used, occupied or utilized by anyone other than Tenant, or (c) mortgage, pledge, encumber or otherwise hypothecate this Lease or the Premises or any part thereof in any manner whatsoever, without in each instance obtaining the prior consent of
 Landlord.

Section 15.2    If and so long as Tenant is a corporation or a partnership, the following shall be deemed to be an assignment of this Lease under Section 15.1 prohibited by said Section unless Tenant obtains the prior consent of Landlord: one or more sales or transfers of stock
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partnership interests, voluntarily, involuntarily, by operation of law or otherwise, or the issuance of new stock or partnership interests, by which an aggregate of more than 50% of Tenant’s stock or partnership interests shall be vested in a party or parties who are not stockholders or
 partners as of the date hereof. This Section shall not apply to transactions with a corporation, limited liability company or partnership into or with which Tenant is merged or consolidated or to which substantially all of Tenant’s assets are transferred or to any corporation, limited liability
 company or partnership (an “Affiliate”) which controls Tenant or is controlled by Tenant or is under common control with Tenant if (a) the successor to Tenant has a tangible net worth computed in accordance with generally accepted accounting principles at least equal to the greater of
 (i) the tangible net worth of Tenant immediately prior to such merger, consolidation or transfer, or (ii) the tangible net worth on the date of this Lease of the original Tenant herein named, and (b) proof satisfactory to Landlord of such tangible net worth is delivered to Landlord at least 10
 days prior to the effective date of any such transaction. The provisions of this Section shall not apply to any corporation all the outstanding voting stock of which is listed on a national securities exchange (as defined in the Securities Exchange Act of 1934, as amended) or is traded in the
 over-the-counter market with quotations reported by the National Association of Securities Dealers through its automated system for reporting quotations. The term “control” as used in this Lease (i) in the case of a corporation shall mean ownership of more than fifty (50%) percent of
 the outstanding voting common capital stock of that corporation, (ii) in the case of a general or limited liability partnership, shall mean more than fifty (50%) percent of the general partnership or membership interest of the partnership, (iii) in the case of a limited partnership, shall mean
 more than fifty (50%) percent of the general partnership interests of such limited partnership, and (iv) in the case of a limited liability company, shall mean more than fifty (50%) percent of the membership interests of such limited liability company.

Section 15.3    If this Lease is assigned, whether or not in violation of the provisions of this Lease, Landlord may collect rent from the assignee. If the Premises or any part thereof are sublet or used or occupied by anybody other than Tenant, whether or not in violation of this
 Lease, Landlord may, after default by Tenant, and expiration of Tenant’s time to cure such default, collect rent from the subtenant or occupant. In either event, Landlord may apply the net amount collected to the Fixed Rent and Additional Rent herein reserved, but no such assignment,
 subletting, occupancy or collection shall be deemed a waiver of any of the provisions of Section 15.1, or the acceptance of the assignee, subtenant or occupant as tenant, or a release of Tenant from the performance by Tenant of Tenant’s obligations under this Lease. The consent by
 Landlord to assignment, mortgaging, subletting or use or occupancy by others shall not in any way be considered to relieve Tenant from obtaining the consent of Landlord to any other or further assignment, mortgaging, subletting or use or occupancy by others not expressly permitted by
 this Article. References in this Lease to use or occupancy by others (that is, anyone other than Tenant) shall not be construed as limited to subtenants and those claiming under or through subtenants but as including also licensees and others claiming under or through Tenant, immediately
 or remotely.

Section 15.4    Any assignment or transfer, whether made with Landlord’s consent pursuant to Section 15.1 or without the requirement of Landlord’s consent pursuant to Section 15.2, shall be made only if, and shall not be effective until, the assignee shall execute,
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satisfactory to Landlord whereby the assignee shall assume the obligations of this Lease on the part of Tenant to be performed or observed and whereby the assignee shall agree that the provisions in Section 15.1 shall, notwithstanding such assignment or transfer, continue to be binding
 upon it in respect of all future assignments and transfers. Notwithstanding any assignment or transfer, whether or not in violation of the provisions of this Lease, and notwithstanding the acceptance of the Fixed Rent or Additional Rent by Landlord from an assignee, transferee, or any
 other party, the original named Tenant shall remain fully liable for the payment of the Fixed Rent and Additional Rent and for the other obligations of this Lease on the part of Tenant to be performed or observed.

Section 15.5    The liability of Tenant and any immediate or remote successor in interest of Tenant and the due performance of the obligations of this Lease on Tenant’s part to be performed or observed shall not be discharged, released or impaired in any respect by any
 agreement or stipulation made by Landlord with the then Tenant extending the time of, or modifying any of the obligations of, this Lease, or by any waiver or failure of Landlord to enforce any of the obligations of this Lease.

Section 15.6    Neither the listing of any name other than that of Tenant, whether on the door of the Premises or on any directory, or otherwise, nor the acceptance by Landlord of any check not drawn by Tenant in payment of Fixed Rent or Additional Charges, shall operate to
 vest any right or interest in this Lease or in the Premises, nor shall it be deemed to be the consent of Landlord to any assignment or transfer of this Lease or to any sublease of the Premises or to the use or occupancy thereof by others.

Section 15.7    Except as specifically provided to the contrary in this Article 15, if Tenant shall at any time or times during the Term desire to assign this Lease or sublet all or any part of the Premises, Tenant shall give notice thereof to Landlord, which notice shall be
 accompanied by (a) a conformed or photostatic copy of the proposed assignment or sublease, the effective or commencement date of which shall be at least 60 days after the giving of such notice, (b) a statement setting forth in reasonable detail the identity of the proposed assignee or
 subtenant, the nature of its business and its proposed use of the Premises, and (c) current financial information with respect to the proposed assignee or subtenant, including, without limitation, its most recent financial report. Such notice shall be deemed an offer from Tenant to Landlord
 whereby Landlord (or Landlord’s designee) may, at its option, (i) sublease such space from Tenant upon the terms and conditions hereinafter set forth or (ii) terminate this Lease (if the proposed transaction is an assignment or a sublease of all or substantially all of the Premises). Said
 options may be exercised by Landlord by notice to Tenant at any time within 60 days after such notice has been given by Tenant to Landlord; and during such 60-day period Tenant shall not assign this Lease or sublet such space to any person.

Section 15.8    If Landlord exercises its option to terminate this Lease in the case where Tenant desires either to assign this Lease or sublet all or substantially all of the Premises, then this Lease shall end and expire on the date that such assignment or sublet was to be effective
 or commence, as the case may be, and the Fixed Rent and Additional Rent shall be paid and apportioned to such date.

 

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Section 15.9    If Landlord exercises its option to sublet the Premises which Tenant desires to sublet, such sublease to Landlord or its designee (as subtenant) shall be at the rentals set forth in the proposed sublease, and shall be for the same term as that of the proposed
 subletting, and:

(A)    the sublease shall be expressly subject to all of the covenants, agreements, terms, provisions and conditions of this Lease except such as are irrelevant or inapplicable, and except as otherwise expressly set forth to the contrary in this Section;

(B)    such sublease shall be upon the same terms and conditions as those contained in the proposed sublease, (i) except such as are irrelevant or inapplicable and except as expressly set forth to the contrary in this Section and (ii) except that such sublease shall
 contain provisions analogous to Section 15.16, obligating the sublessee to share net assignment or sub-subletting profits with Tenant and such assignment or sub-subletting profits shall be further shared with Landlord pursuant to Section 15.16;

(C)    such sublease shall give the sublessee the unqualified and unrestricted right, without Tenant’s permission, to assign such sublease or any interest therein and/or to further sublet the Premises or any part or parts thereof and to make any and all changes,
 alterations, and improvements in the Premises;

(D)    such sublease shall provide that any assignee or further subtenant of Landlord or its designee may, at the election of Landlord, be permitted to make alterations, decorations and installations in such space or any part thereof and shall also provide in substance
 that (i) any such alterations, decorations and installations in such space therein made by any assignee or subtenant of Landlord or its designee may be removed, in whole or in part, by such assignee or subtenant, at its option, prior to or upon the expiration or other termination of such
 sublease provided that such assignee or subtenant, at its expense, shall repair any damage and injury to such space or sublet caused by such removal and (ii) if such sublease is for a term ending more than one year prior to the end of the Term, such assignee or subtenant shall, at Tenant’s
 option, restore such space substantially to the condition thereof prior to such alterations and installations, to the extent such alterations and installations are not consented to by Tenant and would not have been permitted without such consent under the terms of Tenant’s proposed
 sublease; and

(E)    such sublease shall provide that (i) the parties to such sublease expressly negate any intention that any estate created under such sublease be merged with any other estate held by either of said parties, (ii) any assignment or further subletting by Landlord or its
 designee (as the sublessor) may be for any purpose or purposes that Landlord, in Landlord’s uncontrolled discretion, shall deem suitable or appropriate, and (iii) at the expiration of the term of such sublease, Tenant will accept the space covered by such sublease in its then existing
 condition, subject to the obligations of the subtenant to make such repairs thereto as may be necessary to preserve the premises demised by such sublease in good order and condition, ordinary wear and tear and damage by fire or other casualty excepted.

Section 15.10 If Landlord does not exercise its options pursuant to Section 15.7 to so sublet the Premises or terminate this Lease and providing that Tenant is not in default of any of

 

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Tenant’s obligations under this Lease, Landlord’s consent (which shall be in form reasonably satisfactory to Landlord) to the proposed assignment or sublease shall not be unreasonably withheld or delayed, provided and upon condition that:

(A)    Tenant shall have complied with the provisions of Section 15.7 and Landlord shall not have exercised any of its options under said Section 15.7 within the time permitted therefor;

(B)    in Landlord’s judgment the proposed assignee or subtenant is engaged in a business and the Premises will be used in a manner which (i) is in keeping with the then standards of the Building, (ii) is limited to the use expressly permitted under Section 5.1, or
 any other office, laboratory or similar use which complies with Legal Requirements and insurance requirements and otherwise with the provisions of this Lease, and (iii) will not violate any negative covenant as to use contained in any other lease of space in the Project;

(C)    the proposed assignee or subtenant is a reputable person of good character and with sufficient financial worth considering the responsibility involved, and Landlord has been furnished with reasonable proof thereof;

(D)    neither (i) the proposed assignee or sublessee nor (ii) any person which, directly or indirectly, controls, is controlled by, or is under common control with, the proposed assignee or sublessee or any person who controls the proposed assignee or sublessee, is
 then an occupant of any part of the Project, unless Landlord does not have available and will not have available within a reasonable period of time, space which is similar in size, condition and contiguity to that which is proposed to be sublet or assigned;

(E)    the proposed assignee or sublessee is not a person with whom Landlord is then negotiating or in the prior three-month period was negotiating to lease space in the Project;

(F)    the form of the proposed sublease shall be in form reasonably satisfactory to Landlord and shall comply with the applicable provisions of this Article; and

(G)    the consent of any Mortgagee whose Mortgage requires the consent of the Mortgagee shall have been obtained.

Section 15.11 Tenant shall reimburse Landlord on demand for any reasonable costs that may be incurred by Landlord in connection with any proposed assignment or sublease, whether consented to by Landlord or not, including, without limitation, the costs of making
 investigations as to the acceptability of the proposed assignee or subtenant, and legal costs incurred in connection with the granting of any requested consent.

Section 15.12 The amount of the aggregate rent per rentable square foot to be paid by a proposed subtenant under a proposed sublease shall not be less than the then current market rent per rentable square foot for the Premises as though the Premises were vacant. The rental and
 other terms and conditions of any actual sublease shall be the same as those contained in the proposed sublease furnished to Landlord pursuant to Section 15.7. Tenant shall not (a) advertise or publicize in any way the availability of the Premises without prior notice to and approval by

 

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Landlord, or (b) advertise the Premises for subletting, whether through a broker, agent, representative or otherwise at a rental rate less than the Fixed Rent and Additional Rent at which Landlord is then offering to lease comparable space in the Project.

Section 15.13 Except for any subletting by Tenant to Landlord or its designee pursuant to the provisions of this Article, each subletting pursuant to this Article shall be subject to all of the covenants, agreements, terms, provisions and conditions contained in this Lease.
 Notwithstanding any such subletting to Landlord or any such subletting to any other subtenant and/or acceptance of rent or additional rent by Landlord from any subtenant, Tenant shall and will remain fully liable for the payment of the Fixed Rent and Additional Rent due and to become
 due hereunder and, subject to Section 15.9(f), for the performance of all the covenants, agreements, terms, provisions and conditions contained in this Lease on the part of Tenant to be performed and all acts and omissions of any licensee or subtenant or anyone claiming under or through
 any subtenant which shall be in violation of any of the obligations of this Lease, and any such violation shall be deemed to be a violation by Tenant. Tenant further agrees that notwithstanding any such subletting, no other and further subletting of the Premises by Tenant or any person
 claiming through or under Tenant (except as provided in Section 15.9) shall or will be made except upon compliance with and subject to the provisions of this Article. Whether or not Landlord declines to give its consent to any proposed assignment or sublease, or if Landlord shall
 exercise any of its options under Section 15.7, Tenant shall indemnify, defend and hold harmless Landlord against and from any and all loss, liability, damages, costs and expenses (including reasonable counsel fees) resulting from any claims that may be made against Landlord by the
 proposed assignee or sublessee or by any brokers or any other persons claiming a commission or similar compensation in connection with the proposed assignment or sublease.

Section 15.14 If (a) Landlord fails to exercise all of its options under Section 15.7 and Landlord consents to a proposed assignment or sublease, and (b) Tenant fails to execute and deliver the assignment or sublease to which Landlord consented within 90 days after the giving
 of such consent, then Tenant shall again comply with all of the provisions and conditions of Section 15.7 before assigning this Lease or subletting all or any part of the Premises.

Section 15.15 With respect to each and every sublease or subletting authorized by Landlord under the provisions of this Lease, it is further agreed that:

(A)    no subletting shall be for a term ending later than one day prior to the expiration date of this Lease;

(B)    no sublease shall be valid, and no subtenant shall take possession of the Premises or any part thereof, until an executed counterpart of such sublease has been delivered to Landlord; and

(C)    each sublease shall provide that it is subject and subordinate to this Lease and to the matters to which this Lease is or shall be subordinate, and that in the event of termination, reentry or dispossess by Landlord under this Lease Landlord may, at its option,
 take over all of the right, title and interest of Tenant, as sublessor, under such sublease, and such subtenant shall, at Landlord’s option, attorn to Landlord pursuant to the then executory provisions of such sublease, except that Landlord shall not (i) be liable for any previous act or

 

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omission of Tenant under such sublease, (ii) be subject to any offset which theretofore accrued to such subtenant against Tenant, or (iii) be bound by any previous modification of such sublease or by any previous prepayment of more than one month’s rent.

(D)    If (i) a subtenant of Tenant, under a sublease for which Landlord’s consent is required hereunder and has been obtained, has a minimum net worth calculated in accordance with generally accepted accounting principles equal to at least six times the aggregate
 of the annual fixed rent, operating payments and tax payments provided for in such sublease (ii) such sublease (A) has a term of five (5) years or more, (B) provides for the demise of at least 50% of the rentable area of the Premises and (C) provides on a per rentable square foot basis for a
 fixed rental and additional rent equal to or greater than the Fixed Rent and Additional Charges provided for in this Lease (or which provides for the escalation of such subtenant’s rental to such level at such time as it seeks to invoke the protections of this Section), and (iii) Landlord shall
 be reimbursed for its reasonable out-of-pocket costs in connection therewith (including, without limitation, reasonable legal fees), then Landlord shall execute and deliver to such subtenant, at the time such sublease is made, a non-disturbance agreement in form reasonably satisfactory to
 Landlord, confirming Landlord’s agreement hereunder to recognize such subtenant as the direct tenant of Landlord upon the termination of this Lease by reason of a default by Tenant, provided that at the time of the termination of this Lease (x) no default exists under the subtenant’s
 sublease which would then permit the landlord thereunder to terminate the sublease or to exercise any dispossess remedy provided for therein and (y) the subtenant will deliver to Landlord an instrument confirming the agreement of the subtenant to attorn to Landlord and to recognize
 Landlord as such subtenant’s landlord under the sublease, which instrument shall provide that neither Landlord nor anyone claiming by, through or under Landlord, shall be:

(1)    liable for any act or omission of any prior landlord (including the then-defaulting landlord),

(2)    subject to any offsets or defenses which the subtenant may have against any prior landlord (including the then-defaulting landlord),

(3)    bound by any payment of rent which the subtenant might have made for more than one (1) month in advance of the due date of any corresponding rental obligation under this Lease to any prior landlord (including the then-defaulting landlord),

(4)    liable for any security deposited by such subtenant which has not been transferred as such to Landlord,

(5)    bound by any covenant to undertake or complete any construction of the premises demised by said sublease,

(6)    bound by any obligation to make any payment to the subtenant, except for services, repairs, maintenance and restoration provided for under the sublease to be performed after the date of such termination of this Lease to the extent Landlord would
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(7)    bound by any modification of the sublease to which Landlord shall have not consented in writing.

Section 15.16 If Landlord gives its consent to any assignment of this Lease or to any sublease, Tenant shall, in consideration therefor, pay to Landlord, as Additional Rent one half of:

(A)    in the case of an assignment, an amount equal to all sums and other considerations paid to Tenant by the assignee for or by reason of such assignment (including, without limitation, sums paid for the sale of Tenant’s fixtures, leasehold improvements,
 equipment, furniture, furnishings or other personal property, less the then net unamortized or undepreciated cost thereof determined on the basis of Tenant’s federal income tax returns), but excluding sums, not exceeding the fair market value, paid for the sale of Tenant’s laboratory or
 other similar technical or movable equipment (the sums payable under this subsection (A) shall be paid to Landlord as and when paid by the subtenant to Tenant); and

(B)    in the case of a sublease, (i) any rents, additional charges or other consideration payable under the sublease to Tenant by the subtenant which is in excess of the Fixed Rent and Additional Rent accruing during the term of the sublease in respect of the
 subleased space (at the rate per square foot payable by Tenant hereunder) pursuant to the terms hereof (including, without limitation, sums paid for the sale or rental of Tenant’s fixtures, leasehold improvements, equipment, furniture, furnishings or other personal property, less, in the
 case of the sale thereof, the then net unamortized or undepreciated cost thereof determined on the basis of Tenant’s federal income tax returns, which net unamortized or undepreciated cost shall be deducted from the sums paid in connection with such sale in equal monthly installments
 over the balance of the term of the sublease) , but excluding sums, not exceeding the fair market value, paid for the sale of Tenant’s laboratory or other similar technical or movable equipment, minus (ii) Tenant’s reasonable out-of-pocket costs of effectuating such sublease (including,
 without limitation, brokerage fees, attorneys’ fees and the cost of alterations performed for the subtenant), which costs shall be amortized and deducted in equal monthly installments over the balance of the term of the sublease. The sums payable under this subsection (B) shall be paid to
 Landlord as and when paid by the subtenant to Tenant.

ARTICLE 16

ACCESS TO PREMISES

Section 16.1    (A)    Tenant shall permit Landlord, Landlord’s agents and public utilities servicing the Building to erect, use and maintain concealed ducts, pipes and conduits in and through the Premises. Landlord or Landlord’s agents shall have the right to enter the
 Premises at all reasonable times upon (except in case of emergency) reasonable prior notice, which notice may be oral, to examine the same, to perform audits or inspections for Hazardous Materials, to show the same to prospective purchasers, Mortgagees or lessees of the Building or
 space therein, or to make such repairs, alterations, improvements or additions (i) as Landlord may deem necessary or desirable to the Premises or to any other portion of the Building, or (ii) which Landlord may elect to perform at least ten (10) days after notice (except in an emergency
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perform any work which Tenant is obligated to make or perform under this Lease, or (iii) for the purpose of complying with Requirements, and Landlord shall be allowed to take all material into and upon the Premises that may be required therefor without the same constituting an
 eviction or constructive eviction of Tenant in whole or in part and the Fixed Rent (and any other item of Rental) shall in no respect abate or be reduced by reason of said repairs, alterations, improvements or additions, wherever located, or while the same are being made, by reason of loss
 or interruption of business of Tenant, or otherwise. Landlord shall promptly repair any damage caused to the Premises by such work, alterations, improvements or additions. Landlord shall not store materials in the Premises (except during performance of the work), unless they are
 confined to the area in which such alterations, additions and improvements are being performed. In exercising its rights under this Section 16.1, Landlord shall attempt to coordinate with Tenant in making any repairs, alterations or improvements in the Premises and shall use reasonable
 efforts to minimize interference with Tenant’s conduct of business in the Premises, provided Landlord shall not be required to use overtime labor.

(B)    Any work performed or installations made pursuant to this Article 16 shall be made with reasonable diligence and otherwise pursuant to Section 7.3.

(C)    Any pipes, ducts, or conduits installed in or through the Premises pursuant to this Article 16 shall, if reasonably practicable, either be concealed behind, beneath or within partitioning, columns, ceilings or floors located or to be located in the Premises, or
 completely furred at points immediately adjacent to partitioning, columns or ceilings located or to be located in the Premises.

Section 16.2    If Tenant is not present when for any reason entry into the Premises may be necessary or permissible, Landlord or Landlord’s agents may enter the same without rendering Landlord or such agents liable therefor (if during such entry Landlord or Landlord’s
 agents accord reasonable care to Tenant’s Property), and without in any manner affecting this Lease.

Section 16.3    Landlord also shall have the right at any time, without the same constituting an actual or constructive eviction and without incurring any liability to Tenant therefor, to change the arrangement or location of entrances or passageways, doors and doorways, and
 corridors, elevators, stairs, toilets or other public parts of the Building, provided any such change does not unreasonably interfere with, or deprive Tenant of access to, the Building or the Premises; to put so-called “solar film” or other energy-saving installations on the inside and outside
 of the windows; and to change the name, number or designation by which the Building and/or the Project are commonly known. All parts (except surfaces facing the interior of the Premises) of all walls, windows and doors bounding the Premises (including exterior Building walls,
 exterior core corridor walls, exterior doors and entrances), all space in or adjacent to the Premises used for shafts, stacks, stairways, chutes, pipes, conduits, ducts, fan rooms, heating, air cooling, plumbing and other mechanical facilities, service closets and other Building facilities are not
 part of the Premises, and Landlord shall have the use thereof, as well as access thereto through the Premises for the purposes of inspection, operation, maintenance, alteration and repair.

 

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Section 16.4    Tenant agrees to permit Emisphere’s IT telecom personnel access during business hours, upon telephonic notice, to the satellite closets located in the Space A Premises until such time as Emisphere has surrendered the Space C Premises.

ARTICLE 17

CERTIFICATE OF OCCUPANCY

Section 17.1    Tenant shall not at any time use or occupy the Premises in violation of the certificate of occupancy at such time issued for the Premises or for the Building. Without limiting the generality of the foregoing, if the certificate of occupancy for the Premises or the
 Building limits the total number of persons permitted to occupy the floor of the Building on which the Premises is located, then Tenant shall be entitled to use the Premises to accommodate a proportionate share of the total number of persons permitted by the certificate of occupancy to
 occupy the floor of the Building on which the Premises is located, based upon the ratio that the rentable square footage of the Premises bears to the total rentable square footage on such floor of the Building. In the event that any Government Authority hereafter contends or declares by
 notice, violation, order or in any other manner whatsoever that the Premises are used for a purpose that is a violation of such certificate of occupancy, Tenant shall, upon three (3) Business Days’ written notice from Landlord or any Government Authority, immediately discontinue such
 use of the Premises; provided, however, that nothing herein shall prevent Tenant from contesting such violation pursuant to and in accordance with the provisions of Section 9.5.

ARTICLE 18

DEFAULT

Section 18.1    Each of the following events shall be an “Event of Default” under this Lease:

(A)    if Tenant shall on any occasion default in the payment when due of any installment of Fixed Rent or in the payment when due of any other item of Rental and such default shall continue for five (5) Business Days after Landlord shall have given Tenant
 written notice of such default; or

(B)    if Tenant shall fail more than three (3) times in any period of twelve consecutive months to make a payment when due of any Rental, and Landlord shall have given Tenant notice of such default after three such occurrences; or

(C)    omitted; or

(D)    if the Premises shall become vacant or abandoned; or

 

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(E)    if Tenant’s interest in this Lease shall devolve upon or pass to any person, whether by operation of law or otherwise, except as expressly permitted under Article 15 hereof; or

(F)      (1)    if Tenant shall not, or shall be unable to, or shall admit in writing Tenant’s inability to, as to any obligation, pay Tenant’s debts as they become due; or

(2)    if Tenant shall commence or institute any case, proceeding or other action (a) seeking relief on Tenant’s behalf as debtor, or to adjudicate it a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment, winding-up, liquidation,
 dissolution, composition or other relief with respect to Tenant or Tenant’s debts under any existing or future law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency, reorganization or relief of debtors, or (b) seeking appointment of a receiver, trustee, custodian or
 other similar official for it or for all or any substantial part of its property; or

(3)    if Tenant shall make a general assignment for the benefit of creditors; or

(4)    if any case, proceeding or other action shall be commenced or instituted against Tenant (a) seeking to have an order for relief entered against Tenant as debtor or to adjudicate Tenant a bankrupt or insolvent, or seeking reorganization, arrangement,
 adjustment, winding-up, liquidation, dissolution, composition or other relief with respect to Tenant or Tenant’s debts under any existing or future law of any jurisdiction, domestic or foreign, relating to bankruptcy, insolvency, reorganization or relief of debtors, or (b) seeking
 appointment of a receiver, trustee, custodian or other similar official for Tenant or for all or any substantial part of Tenant’s property, which either (i) results in any such entry of an order for relief, adjudication of bankruptcy or insolvency or such an appointment or the issuance or entry
 of any other order having a similar effect or (ii) remains undismissed for a period of ninety (90) days; or

(5)    if any case, proceeding or other action shall be commenced or instituted against Tenant seeking issuance of a warrant of attachment, execution, distraint or similar process against all or any substantial part of Tenant’s property which results in the
 entry of an order for any such relief which is not vacated, discharged, stayed or bonded pending appeal within ninety (90) days from the entry thereof; or

(6)    if Tenant shall take any action in furtherance of, or indicating Tenant’s consent to, approval of, or acquiescence in, any of the acts set forth in clauses (2), (3), (4) or (5) above; or

  (7)   if
      a trustee, receiver or other custodian shall be appointed for any substantial
      part of the assets of Tenant which appointment is not vacated or effectively
      stayed within ninety (90) days; or

(G)    if Tenant shall default in the observance or performance of any other term, covenant or condition of this Lease on Tenant’s part to be observed or performed and Tenant shall fail to remedy such default within 30 days after notice by Landlord to Tenant of
 such

 

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default, or if such default is of such a nature that it cannot with due diligence be completely remedied within said period of 30 days and the continuation of which for the period required for cure will not subject Landlord to the risk of criminal liability or termination of any Superior Lease
 or foreclosure of any Mortgage, if Tenant shall not, (i) within said 30 day period advise Landlord of Tenant’s intention duly to institute all steps necessary to remedy such situation, (ii) duly institute within said 30 day period, and thereafter diligently and continuously prosecute to
 completion all steps necessary to remedy the same and (iii) complete such remedy within such time after the date of the giving of said notice by Landlord as shall reasonably be necessary.

Section 18.2    If an Event of Default shall occur, Landlord may, at any time thereafter, at Landlord’s option, give written notice to Tenant stating that this Lease and the Term shall expire and terminate on the date specified in such notice, which date shall not be less than
 three (3) days after the giving of such notice, whereupon this Lease and the Term and all rights of Tenant under this Lease shall automatically expire and terminate as if the date specified in the notice given pursuant to this Section 18.2 were the Fixed Expiration Date and Tenant
 immediately shall quit and surrender the Premises, but Tenant shall remain liable for damages as provided herein or pursuant to law. Anything contained herein to the contrary notwithstanding, if such termination shall be stayed by order of any court having jurisdiction over any
 proceeding described in Section 18.1(F), or by federal or state statute, then, following the expiration of any such stay, or if the trustee appointed in any such proceeding, Tenant or Tenant as debtor-in-possession fails to assume Tenant’s obligations under this Lease within the period
 prescribed therefor by law or within one hundred twenty (120) days after entry of the order for relief or as may be allowed by the court, or if said trustee, Tenant or Tenant as debtor-in-possession shall fail to provide adequate protection of Landlord’s right, title and interest in and to the
 Premises or adequate assurance of the complete and continuous future performance of Tenant’s obligations under this Lease, Landlord, to the extent permitted by law or by leave of the court having jurisdiction over such proceeding, shall have the right, at its election, to terminate this
 Lease on three (3) days’ notice to Tenant, Tenant as debtor-in-possession or said trustee and upon the expiration of said three (3) day period this Lease shall cease and expire as aforesaid and Tenant, Tenant as debtor-in-possession or said trustee shall immediately quit and surrender the
 Premises as aforesaid.

Section 18.3    If, at any time, (i) Tenant shall consist of two (2) or more persons, or (ii) Tenant’s obligations under this Lease shall have been guaranteed by any person other than Tenant, or (iii) Tenant’s interest in this Lease has been assigned, the word “Tenant” as used in
 Section 18.1(F), shall be deemed to mean any one or more of the persons primarily or secondarily liable for Tenant’s obligations under this Lease. Any monies received by Landlord from or on behalf of Tenant during the pendency of any proceeding of the types referred to in Section
 18.1(F) shall be deemed paid as compensation for the use and occupancy of the Premises and the acceptance of any such compensation by Landlord shall not be deemed an acceptance of Rental or a waiver on the part of Landlord of any rights under Section 18.2.

 

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ARTICLE 19

REMEDIES AND DAMAGES

Section 19.1    (A)    If any Event of Default shall occur, or this Lease and the Term shall expire and come to an end as provided in Article 18:

(1)    Tenant shall quit and peacefully surrender the Premises to Landlord, and Landlord and its agents may immediately, or at any time after such Event of Default or after the date upon which this Lease and the Term shall expire and come to an end,
 re-enter the Premises or any part thereof, without notice, either by summary proceedings, or by any other applicable action or proceeding, or by force or otherwise (without being liable to indictment, prosecution or damages therefor), and may repossess the Premises and dispossess
 Tenant and any other persons from the Premises by summary proceedings or otherwise and remove any and all of their property and effects from the Premises (and Tenant shall remain liable for damages as provided herein or pursuant to law); and

(2)    Landlord, at Landlord’s option, may relet the whole or any part or parts of the Premises from time to time, either in the name of Landlord or otherwise, to such tenant or tenants, for such term or terms ending before, on or after the Fixed Expiration
 Date, at such rent or rentals and upon such other conditions, which may include concessions and free rent periods, as Landlord, in Landlord’s sole discretion, may determine; provided, however, that Landlord shall have no obligation to relet the Premises or any part thereof and shall in no
 event be liable for refusal or failure to relet the Premises or any part thereof, or, in the event of any such reletting, for refusal or failure to collect any rent due upon any such reletting, and no such refusal or failure shall operate to relieve Tenant of any liability under this Lease or otherwise
 affect any such liability, and Landlord, at Landlord’s option, may make such Alterations, in and to the Premises as Landlord, in Landlord’s sole discretion, shall consider advisable or necessary in connection with any such reletting or proposed reletting, without relieving Tenant of any
 liability under this Lease or otherwise affecting any such liability.

(B)    Tenant hereby waives the service of any notice of intention to re-enter or to institute legal proceedings to that end that may otherwise be required to be given under any present or future law. Tenant, on its own behalf and on behalf of all persons claiming
 through or under Tenant, including all creditors, does further hereby waive any and all rights that Tenant and all such persons might otherwise have under any present or future law to redeem the Premises, or to re-enter or repossess the Premises, or to restore the operation of this Lease,
 after (a) Tenant shall have been dispossessed by a judgment or by warrant of any court or judge, or (b) any re-entry by Landlord, or (c) any expiration or termination of this Lease and the Term, whether such dispossess, re-entry, expiration or termination is by operation of law or pursuant
 to the provisions of this Lease. The words “re-entry”, “re-enter” and “re-entered” as used in this Lease shall not be deemed to be restricted to their technical legal meanings. In the event of a breach or threatened breach by Tenant, or any persons claiming through or under Tenant, of any
 term, covenant or condition of this Lease, Landlord shall have the right to enjoin such breach and the right to invoke any other remedy allowed by law or in equity as if re-entry, summary proceedings and other special remedies were not provided in this Lease for such breach. The

 

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right to invoke the remedies hereinbefore set forth are cumulative and shall not preclude Landlord from invoking any other remedy allowed at law or in equity.

Section 19.2    (A)    If this Lease and the Term shall expire and come to an end as provided in Article 18, or by or under any summary proceeding or any other action or proceeding, or if Landlord shall re-enter the Premises as provided in Section 19.1, or by or under any
 summary proceeding or any other action or proceeding, then, in any of said events:

(1)    Tenant shall pay to Landlord all Fixed Rent, all Additional Rent (including Additional Rent payable pursuant to Articles 3 and 4) and other items of Rental payable under this Lease by Tenant to Landlord to the date upon which this Lease and the
 Term shall have expired and come to an end or to the date of re-entry upon the Premises by Landlord, as the case may be;

(2)    Tenant also shall be liable for and shall pay to Landlord, as damages, any deficiency (“Deficiency”) between the Rental for the period which otherwise would have constituted the unexpired portion of the Term and the net amount, if any, of rents
 collected under any reletting effected pursuant to the provisions of Section 19.1(A)(2) for any part of such period (after first deducting from the rents collected under any such reletting all of Landlord’s expenses in connection with the termination of this Lease, Landlord’s reentry upon
 the Premises and such reletting including, but not limited to, all repossession costs, brokerage commissions, attorneys’ fees and disbursements, alteration costs and other expenses of preparing the Premises for such reletting); any such Deficiency shall be paid in monthly installments by
 Tenant on the days specified in this Lease for payment of installments of Fixed Rent; Landlord shall be entitled to recover from Tenant each monthly Deficiency as the same shall arise, and no suit to collect the amount of the Deficiency for any month shall prejudice Landlord’s right to
 collect the Deficiency for any subsequent month by a similar proceeding; and

(3)    whether or not Landlord shall have collected any monthly Deficiency as aforesaid, Landlord shall be entitled to recover from Tenant, and Tenant shall pay to Landlord, on demand, in lieu of any further Deficiency as and for liquidated and agreed
 final damages, a sum equal to the amount by which the unpaid Rental for the period which otherwise would have constituted the unexpired portion of the Term exceeds the then fair and reasonable rental value of the Premises for the same period, both discounted to present worth at four
 (4%) percent per annum less than the Base Rate; if, before presentation of proof of such liquidated damages to any court, commission or tribunal, the Premises, or any part thereof, are relet by Landlord for the period which otherwise would have constituted the unexpired portion of the
 Term, or any part thereof, the amount of rent reserved upon such reletting shall be deemed, prima facie, to be the fair and reasonable rental value for the part or the whole of the Premises so relet during the term of the reletting.

(B)    If the Premises, or any part thereof, shall be relet together with other space in the Building, the rents collected or reserved under any such reletting and the expenses of any such reletting shall be equitably apportioned for the purposes of this Section 19.2.
 Tenant shall in no event be entitled to any rents collected or payable under any reletting (except as a credit against amounts owing to Landlord as set forth above), whether or not such rents exceed the

 

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Fixed Rent reserved in this Lease. Solely for the purposes of this Article 19, the phrase “Additional Rent payable pursuant to Articles 3 and 4” as used in Section 19.2(A) shall mean the Additional Rent payable pursuant to Articles 3 and 4 in effect immediately prior to the Expiration
 Date, or the date of re-entry upon the Premises by Landlord, as the case may be. Nothing contained in Article 18 or this Article 19 shall be deemed to limit or preclude the recovery by Landlord from Tenant of the maximum amount allowed to be obtained as damages by any statute or
 rule of law, or of any sums or damages to which Landlord may be entitled in addition to the damages set forth in this Section 19.2.

ARTICLE 20

FEES AND EXPENSES

Section 20.1    If (i) Tenant shall default under this Lease, or (ii) Tenant does or permits any act or thing upon the Premises, not expressly permitted under this Lease, that would cause Landlord to be in default under any Superior Lease or Mortgage and Tenant does not cure
 such act or thing within 15 days (or such shorter period as Landlord may be permitted pursuant to any Superior Lease or Mortgage) after notice thereof (or without notice in case of emergency), or (iii) Tenant fails to comply with its obligations under this Lease and the preservation of
 property or the safety of any tenant, occupant or other person is threatened, Landlord may (1) perform the same for the account of Tenant (but shall not be obligated to do so), or (2) make any expenditure or incur any obligation for the payment of money in connection with any obligation
 owed to Landlord, including, but not limited to, reasonable attorneys’ fees and disbursements in instituting, prosecuting or defending any action or proceeding, and in either case the cost thereof, with interest thereon at the Applicable Rate, shall be deemed to be Additional Rent
 hereunder and shall be paid by Tenant to Landlord within ten (10) days after rendition of any bill or statement to Tenant therefor. In addition, Tenant shall pay Landlord any reasonable attorneys’ fees and disbursements incurred by Landlord in connection with any proceeding in which
 the value for the use and occupancy of the Premises by Tenant is being determined (but only if such proceeding results from a default by Tenant under this Lease). In the proof of any losses that Landlord may claim against Tenant arising out of Tenant’s failure to maintain insurance,
 Landlord will not be limited to the amount of the unpaid insurance premium but rather Landlord will also be entitled to recover the amount of any uninsured loss (to the extent of any deficiency in the insurance required by the provisions of this Lease), damages, costs, and expenses of
 lawsuit (including attorney’s fees) arising out of damage or destruction occurring during any period for which Tenant has failed to adequately provide such insurance as required. Any reservation of a right by Landlord to enter upon the Premises and to make or perform any repairs,
 Alterations, or other work in, to or about the Premises, which, in the first instance, is Tenant’s obligation pursuant to this Lease, shall not be deemed to: (x) impose any obligation on Landlord to do so, (y) render Landlord liable to Tenant or any third party for the failure to do so, or (z)
 relieve Tenant from any obligation to indemnify Landlord as otherwise provided elsewhere in the Lease.

Section 20.2    If Tenant shall fail to pay any installment of Fixed Rent, Additional Rent or any other item of Rental when due, (i) Tenant shall pay to Landlord, as Additional Rent, on or

 

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before the first day of the following month three and one-half ($.035) cents for each dollar so overdue (but in no event greater than the maximum interest rate permitted by law) in order to defray Landlord’s administrative and other costs in connection with such late payment and (ii)
 Tenant shall pay to Landlord, in addition to such installment of Fixed Rent, Additional Rent or other item of Rental, as the case may be, and in addition to the foregoing late charge, and as Additional Rent, a sum equal to interest at the Applicable Rate on the amount unpaid, computed
 from the date such payment was due to and including the date of payment.

ARTICLE 21

NO REPRESENTATIONS BY LANDLORD

Section 21.1    Landlord and Landlord’s agents have made no representations, warranties or promises with respect to the Building, the Real Property or the Premises except as herein expressly set forth, and no rights, easements or licenses are acquired by Tenant by
 implication or otherwise except as expressly set forth herein. Tenant shall accept possession of the Premises in its “as is” condition on the Commencement Date (including all furniture and equipment owned by Emisphere Technologies Inc. (“Emisphere”) which is not being removed
 from the Premises as more particularly described in Section 40.1), and Landlord shall have no other obligation to perform any work or make any installations in order to prepare the Premises for Tenant’s occupancy. The taking of occupancy of the whole or any part of the Premises by
 Tenant shall be conclusive evidence, as against Tenant, that Tenant accepts possession of the same and that the Premises and the Building were in good and satisfactory condition (excluding latent defects) at the time such occupancy was so taken and that the Premises were substantially
 as shown on Schedule A. All references in this Lease to the consent or approval of Landlord shall be deemed to mean the written consent or approval executed by Landlord and no other consent or approval of Landlord shall be effective for any purpose whatsoever.

ARTICLE 22

END OF TERM

Section 22.1    Upon the expiration or other termination of this Lease, Tenant shall quit and surrender to Landlord the Premises, vacant, broom clean, in good order and condition, ordinary wear and tear excepted, and Tenant shall remove all of Tenant’s Alterations, as may be
 required pursuant to Article 6. Tenant shall also remove all of Tenant’s Property and all other personal property and personal effects of all persons claiming through or under Tenant, and shall pay the cost of repairing all damage to the Premises and the Real Property occasioned by such
 removal. Any Tenant’s Property or other personal property that remains in the Premises after the termination of this Lease shall be deemed to have been abandoned and either may be retained by Landlord as its property or may be disposed of in such manner as Landlord may see fit. If
 such Tenant’s Property or other personal property or any part thereof is sold, Landlord may receive and retain the proceeds of such sale as the property of Landlord. Any expense incurred by Landlord in removing or disposing of such Tenant’s Property or other personal property or
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damage to the Building or the Premises caused by such removal, shall be reimbursed to Landlord by Tenant, as Additional Rent, on demand.

Section 22.2    If the Expiration Date falls on a day which is not a Business Day, then Tenant’s obligations under Section 22.1 shall be performed on or prior to the immediately preceding Business Day.

Section 22.3    Tenant expressly waives, for itself and for any person claiming through or under Tenant, any rights that Tenant or any such person may have under the provisions of Section 2201 of the New York Civil Practice Law and Rules and of any similar or successor
 law of like import then in force in connection with any holdover proceedings that Landlord may institute to enforce the provisions of this Article.

Section 22.4    If the Premises are not surrendered upon the expiration or other termination of this Lease, Tenant hereby indemnifies Landlord against liability or expense (including any consequential damages) resulting from delay by Tenant in so surrendering the Premises,
 including any claims made by any succeeding tenant or prospective tenant founded upon such delay and agrees to be liable to Landlord for (i) any payment or rent concession which Landlord may be required to make to any tenant obtained by Landlord for all or any part of the Premises
 in order to induce such tenant not to terminate its lease by reason of the holding-over by Tenant and (ii) the loss of the benefit of the bargain if any such tenant shall terminate its lease by reason of the holding-over by Tenant.

Section 22.5    Tenant’s obligation under this Article shall survive the expiration or termination of this Lease.

ARTICLE 23

POSSESSION

Section 23.1    (A)    If Landlord shall be unable to deliver possession of the Premises or any additional space to be included within the Premises on the specific date (if any) designated in this Lease for the commencement of the Term or for the inclusion of such space for
 any reason whatsoever, Landlord shall not be subject to any liability therefor and the validity of this Lease shall not be impaired thereby, but the Commencement Date shall be postponed until three (3) Business Days following notice from Landlord that the Premises or such additional
 space are available for occupancy by Tenant. Tenant expressly waives any other right to rescind this Lease under Section 223-a of the New York Real Property Law or under any present or future statute of similar import then in force and further expressly waives the right to recover any
 damages that may result from Landlord’s failure to deliver possession of the Premises or such additional space on the specific date (if any) designated for the commencement of the Term. Tenant agrees that the provisions of this Article 23 are intended to constitute “an express provision
 to the contrary” within the meaning of said Section 223-a. Tenant expressly acknowledges that the Space A Premises is currently occupied by Emisphere and that the Commencement Date is conditioned upon the execution and delivery of an amendment of the lease between Emisphere
 and Landlord which will terminate such lease with respect to the Space A Premises.

 

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(B)    (1)    If Landlord has not delivered possession of Space A Premises by January 1, 2004, Tenant may terminate this Lease and receive a full refund of all of its Security Deposit and pre-paid Fixed Rent upon five (5) days written notice to Landlord.

(2)    If Landlord has not delivered possession of Space B Premises by April 1, 2004, Tenant may terminate this Lease with respect to the Space B Premises only and receive a refund of the pre-paid Fixed Rent allocated to the Space B Premises upon
 five (5) days written notice to Landlord.

(3)    If Landlord has not delivered possession of Space C Premises by February 1, 2004, Tenant may terminate this Lease with respect to the Space C Premises only and receive a refund of the pre-paid Fixed Rent allocated to the Space C Premises
 upon five (5) days written notice to Landlord.

(4)    If Landlord has not delivered possession of Space D Premises by May 1, 2004, Tenant may terminate this Lease with respect to the Space D Premises only and receive a refund of the pre-paid Fixed Rent allocated to the Space D Premises upon
 five (5) days written notice to Landlord.

(C)    If Emisphere surrenders the Space C Premises and/or the Space D Premises prior to the applicable Commencement Date for such spaces as such dates are set forth in the Reference Page, Landlord shall have the right to deliver one or both of such spaces to
 Tenant on not less than five (5) Business Days prior written notice to Tenant. In the event Landlord delivers such notice(s) to Tenant, then the Commencement Date for the Space C Premises and/or the Space D Premises (as applicable) shall be on the day following the expiration of such
 five (5) Business Day period.

ARTICLE 24

NO WAIVER

Section 24.1    No act or thing done by Landlord or Landlord’s agents during the Term shall be deemed an acceptance of a surrender of the Premises, and no agreement to accept such surrender shall be valid unless in writing signed by Landlord. No employee of Landlord or
 of Landlord’s agents shall have any power to accept the keys to the Premises prior to the termination of this Lease. The delivery of keys to any employee of Landlord or of Landlord’s agents shall not operate as a termination of this Lease or a surrender of the Premises. If Tenant shall at
 any time desire to have Landlord sublet the Premises for Tenant’s account, Landlord or Landlord’s agents are authorized to receive the keys for such purpose without releasing Tenant from any of the obligations under this Lease, and Tenant hereby relieves Landlord of any liability for
 loss of or damage to any of Tenant’s effects in connection with such subletting.

Section 24.2    The failure of Landlord to seek redress for violation of, or to insist upon the strict performance of, any covenant or condition of this Lease, or any of the Rules and Regulations, shall not prevent a subsequent act, which would have originally constituted a
 violation, from having all of the force and effect of an original violation. The receipt by

 

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Landlord of Fixed Rent, Additional Rent or any other item of Rental with knowledge of the breach of any covenant of this Lease shall not be deemed a waiver of such breach. The failure of Landlord to enforce any of the Rules and Regulations against Tenant or any other tenant in the
 Building shall not be deemed a waiver of any such Rules and Regulations. No provision of this Lease shall be deemed to have been waived by Landlord, unless such waiver shall be in writing and shall be signed by Landlord. No payment by Tenant or receipt by Landlord of a lesser
 amount than the Rental then due and payable shall be deemed to be other than on account of the earliest item(s) of Rental, or as Landlord may elect to apply the same, nor shall any endorsement or statement on any check or any letter accompanying any check or payment be deemed an
 accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance due of the Rental or pursue any other remedy in this Lease provided. This Lease contains the entire agreement between the parties and all prior
 negotiations and agreements are merged herein. Any executory agreement hereafter made shall be ineffective to change, discharge or effect an abandonment of this Lease in whole or in part unless such executory agreement is in writing and signed by the party against whom enforcement
 of the change, discharge or abandonment is sought.

ARTICLE 25

WAIVER OF TRIAL BY JURY

Section 25.1    Landlord and Tenant shall and they hereby do waive trial by jury in any action, proceeding or counterclaim brought by either of them against the other on any matters whatsoever arising out of or in any way connected with this Lease, the relationship of
 Landlord and Tenant, Tenant’s use or occupancy of the Premises, whether during or after the Term, or for the enforcement of any remedy under any statute, emergency or otherwise. If Landlord shall commence any summary proceeding against Tenant, Tenant will not interpose any
 counterclaim of whatever nature or description in any such proceeding (unless failure to interpose such counterclaim would preclude Tenant from asserting in a separate action the claim which is the subject of such counterclaim), and will not seek to consolidate such proceeding with any
 other action which may have been or will be brought in any other court by Tenant or Landlord.

ARTICLE 26

INABILITY TO PERFORM

Section 26.1    This Lease and the obligation of Tenant to pay Rental hereunder and to perform all of the other covenants and agreements hereunder on the part of Tenant to be performed shall in no way be affected, impaired or excused because Landlord is unable to fulfill
 any of Landlord’s obligations under this Lease, expressly or implicitly to be performed by Landlord, or because Landlord is unable to make or is delayed in making any repairs, additions, alterations, improvements or decorations, or is unable to supply or is delayed in supplying any
 services, equipment or fixtures, if Landlord is prevented from or delayed in so doing by reason of acts of God, casualty, strikes or labor troubles, accident, governmental preemption in connection with an emergency, Requirements, conditions of supply and demand which have been or are

 

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affected by war or other emergency, or any other cause whatsoever (but not lack of funds), whether similar or dissimilar to the foregoing, beyond Landlord’s reasonable control (“Unavoidable Delays”).

ARTICLE 27

BILLS AND NOTICES

Section 27.1    (A)    Except as otherwise expressly provided in this Lease, any bills, statements, consents, approvals, notices, demands, requests or other communications given or required to be given under this Lease (“Notice(s)”) shall be in writing and shall be deemed
 sufficiently given or rendered if delivered by hand (against a signed receipt), by a recognized overnight courier service (with a signed receipt), or if deposited in a securely fastened, postage prepaid envelope in a depository that is regularly maintained by the U.S. Postal Service, sent by
 registered or certified mail (return receipt requested) and in any case addressed:

	 	            if to Tenant (a) at Tenant’s address set forth in this Lease, if given prior to Tenant’s taking possession of the Premises, or (b) at the Building, if given subsequent to Tenant’s taking possession of the Premises, or (c) at any
 place where Tenant or any agent or employee of Tenant may be found if given subsequent to Tenant’s vacating, deserting, abandoning or surrendering the Premises, or

	 	 
	 	            if to Landlord, at Landlord’s address set forth in this Lease, Attn: Director of Property Management, and with a copy to (i) LCOR Asset Management L.P., 777 Old Saw Mill River Road, Tarrytown, New York 10591,
 Attention: Management Office and (ii) any Mortgagee or Lessor who may have requested the same, by Notice given in accordance with the provisions of this Article 27, at the address designated by such Mortgagee or Lessor, or

to such other address(es) as either Landlord or Tenant may designate as its new address(es) for such purpose by notice given to the other in accordance with the provisions of this Article 27.

(B)    Notices shall be deemed to have been rendered or given (i) on the Business Day delivered, if delivered by hand or by recognized overnight courier service, prior to 5:00 p.m. of such Business Day, or if delivered on a day other than a Business Day or after
 5:00 p.m. on any day, then on the next Business Day following such delivery, or (ii) two (2) Business Days after the date mailed, if mailed as provided in Section 27.1(A). Notice given by counsel for either party on behalf of such party or by the Manager on behalf of Landlord shall be
 deemed valid notices if addressed and sent in accordance with the provisions of this Article 27.

Section 27.2    Notwithstanding the provisions of Section 27.1, Notices requesting services for Overtime Periods pursuant to Article 28 may be given by delivery to the Building superintendent or any other person in the Building designated by Landlord to receive such
 Notices, and bills may be rendered by delivering them to the Premises without the necessity of a receipt.

 

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ARTICLE 28

SERVICES AND EQUIPMENT

Section 28.1    Landlord shall (subject to Tenant’s reimbursement obligation pursuant to Article 4):

(A)    Provide passenger elevator service to the Premises 24 hours per day, seven days per week, 365 days per year. Tenant agrees that Landlord may, at its election, install elevators with or without operators and may change the same from time to time.

(B)    Provide one (1) freight elevator serving the Premises on call on a “first come, first served” basis 24 hours per day, seven days per week, 365 days per year.

(C)    Maintain and repair the HVAC System installed by Landlord, except for those repairs which are the obligation of Tenant pursuant to Article 7 of this Lease. Subject to the provisions of Section 28.1(F) below, the HVAC System will be operated by Landlord
 as and for the comfortable occupancy of the Premises (which shall mean in a temperature range of approximately 68o - 74o) during the applicable seasons during Operating Hours; provided that Tenant shall draw and close the draperies or blinds for the windows of the Premises whenever
 the ventilation or air-conditioning system is in operation and the position of the sun so requires and shall, at all times, cooperate fully with Landlord and abide by all of the Rules and Regulations which Landlord may prescribe for the proper functioning of the HVAC System. Tenant shall
 pay Landlord for heat, ventilating and air-conditioning as Additional Rent, within ten days after Landlord bills Tenant therefor, which bills shall be rendered not more often than monthly. The amount of such Additional Rent for a given period of time shall be equal to the total cost to
 Landlord of delivering steam and chilled water for the Premises, which cost shall be determined based upon Landlord’s established mathematical model as described in Schedule G hereto. The performance by Landlord of its obligations under this Section 28.1(C) subject to Tenant’s
 compliance with the conditions of occupancy and connected load established by Landlord. Use of the Premises, or any part thereof, in a manner exceeding the heating, ventilating and/or air-conditioning design conditions (including occupancy and connected electrical load), or
 rearrangement of partitioning which interferes with normal operation of the heating, ventilating and/or air-conditioning in the Premises, or the use of computer or data processing machines or other machines or equipment, may require changes in the heating, ventilating and/or air-
 conditioning systems servicing the Premises, in order to provide comfortable occupancy. Such changes, so occasioned, shall be made by Tenant, at its expense, as Alterations in accordance with the provisions of Article 6, but only to the extent permitted and upon the conditions set forth
 in that Article. Tenant expressly acknowledges that some or all windows are or may be hermetically sealed and will not open and Landlord makes no representation as to the habitability of the Premises at any time the HVAC System is not in operation. Tenant hereby expressly waives
 any claims against Landlord arising out of the cessation of operation of the HVAC System, or the suitability of the Premises when the same is not in operation, whether due to normal scheduling or the reasons set forth in Section 28.2. Landlord, throughout the Term, shall have free
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closets, and Tenant shall not construct partitions or other obstructions that may interfere with Landlord’s free access thereto, or interfere with the moving of Landlord’s equipment to and from the enclosures containing said installations. Neither Tenant nor Persons Within Tenant’s
 Control shall at any time enter the said enclosures or tamper with, adjust, touch or otherwise in any manner affect said mechanical installations. Landlord’s obligations under this Section 28.1(C) are subject to applicable Requirements that may limit the hours or the extent to which
 Landlord is permitted to supply HVAC.

(D)    Furnish hot and cold water for lavatory and drinking and office cleaning purposes. If Tenant requires, uses or consumes water for any other purposes (including for laboratory purposes), Tenant agrees that Tenant shall, if requested by Landlord, install a
 meter or meters or other means to measure Tenant’s water consumption, and Tenant further agrees to pay for the cost of the meter or meters and the installation thereof, and to pay for the maintenance of said meter equipment and/or to pay Landlord’s cost of other means of measuring
 such water consumption by Tenant. Tenant shall reimburse Landlord for the cost of all water consumed (including costs of generating hot water) as measured by said meter or meters or as otherwise measured, including sewer rents, as Additional Rent within ten (10) days after bills are
 rendered.

(E)    Provided Tenant shall keep the Premises in order, Landlord shall cause the Premises, including the exterior and the interior of the windows thereof but excluding any laboratory space, to be cleaned in a manner standard to the Building and in accordance with
 the cleaning specifications annexed to this Lease as Schedule D. Tenant shall pay to Landlord on demand the reasonable costs incurred by Landlord for (a) extra cleaning work in the Premises required because of (i) misuse or neglect on the part of Tenant or its subtenants or its or their
 employees or visitors, (ii) the use of portions of the Premises for special purposes requiring greater or more difficult cleaning work than office areas, (iii) interior glass partitions or unusual quantity of interior glass surfaces, and (iv) special materials or finishes on items installed by
 Tenant or its subtenants or its or their employees or visitors or at its or their request; (b) removal from the Premises and the Building of any refuse or rubbish of Tenant in excess of that ordinarily accumulated in business office occupancy or at times other than Landlord’s standard
 cleaning times; and (c) any additional operating expenses attributable to the use and occupancy of the Premises by Tenant or its subtenants or its or their employees or visitors other than during Business Hours on Business Days. If, however, any additional cleaning of the Premises is to
 be done by Tenant, it shall be done at Tenant’s sole expense, in a manner reasonably satisfactory to Landlord and no one other than persons approved by Landlord shall be permitted to enter the Premises or the Building for such purpose. Tenant, at Tenant’s expense, shall cause the
 Premises to be exterminated on a monthly basis to the satisfaction of Landlord and additionally shall cause all portions of the Premises used for the storage, preparation, service or consumption of food or beverages to be cleaned daily in a manner reasonably satisfactory to Landlord, and
 to be treated against infestation by vermin, rodents or roaches, whenever there is evidence of any infestation. Tenant shall not permit any person to enter the Premises or the Building for the purpose of providing such extermination services, unless such persons have been approved by
 Landlord. If so requested by Landlord, Tenant, at Tenant’s expense, shall store any refuse generated by the consumption of food or beverages on the Premises in a cold box or similar facility. Landlord, its cleaning contractor and their employees shall have access to the Premises after
 5:30 p.m. and before 9:00 a.m. and shall have the right to use, without charge therefor, all light, power and

 

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water in the Premises reasonably required to clean the Premises as required under Section 28.1. Tenant shall comply, at Tenant’s expense, with all Requirements regarding recycling of trash including, but not limited to, separating from the general trash such items as may be required,
 i.e., paper, plastic, glass and aluminum cans.

(F)    Tenant acknowledges and agrees that the air-handler unit (the “Air Handler”) that provides heating, ventilation and air conditioning service (the “HVAC Service”) to the Space C Premises is operated and maintained by Emisphere and that Emisphere shall
 continue to provide HVAC Service to the Space C Premises during the term of Emisphere’s Lease and that Landlord shall have no obligation to provide HVAC Service to the Space C Premise unless and until Emisphere’s lease expires or earlier terminates. Landlord agrees to use
 reasonable effort to enforce Emisphere’s obligation to provide the HVAC Service to the Space C Premises but shall have no liability if Emisphere breaches its obligation to do so. Tenant shall pay to Landlord, as Additional Rent, Tenant’s pro rata share of the cost to Emisphere to
 provide the HVAC Service to the Space C Premises based on the measurement of the airflow to the Space C Premises, as reasonably determined by Landlord. Tenant shall pay for the HVAC Service to the Space C Premises within 15 days after being billed therefor, but not more often
 than monthly. Notwithstanding anything to the contrary contained herein, in the event that Emisphere fails for any reason other than due to “force majeure” (as defined below) to provide the HVAC Service to the Space C Premises and as a result the Space C Premises are rendered
 untenantable, in addition to all of Tenant’s other rights and remedies at law or in equity, Tenant shall be entitled to offset against the Furniture Payment an amount equal to the Fixed Rent for the Space C Premises for the period from the date the Space C Premises becomes untenantable
 through the date when the required HVAC Service is restored, provided, however, that the foregoing offset right shall not apply from and after the date that Emisphere’s lease expires or earlier terminates and Landlord assumes responsibility for such HVAC Service. As used herein, the
 term “force majeure” shall mean events beyond Emisphere’s reasonable control in accordance with the description set forth in Section 41.04 of the lease to Emisphere. The foregoing abatement right shall not apply to any Fixed Rent payable to Landlord for the Premises and shall only
 apply to the Furniture Payment portion of the Fixed Rent.

Section 28.2    (A)    Landlord reserves the right to stop the furnishing of the Building services and to stop service of the Building Systems, when necessary, by reason of accident, or emergency, or for Alterations in the judgment of Landlord desirable or necessary to be
 made, until said Alterations shall have been completed; and Landlord shall have no responsibility or liability for failure to supply air-conditioning, ventilation, heat, elevator, plumbing, electric, gas, steam or other services during said period or when prevented from so doing by strikes,
 lockouts, difficulty of obtaining materials, accidents or by any cause beyond Landlord’s reasonable control, or by Requirements or failure of electricity, water, steam, coal, oil or other suitable fuel or power supply, or inability by exercise of reasonable diligence to obtain electricity,
 water, steam, coal, oil or other suitable fuel or power. No diminution or abatement of rent or other compensation shall or will be claimed by Tenant as a result therefrom, nor shall this Lease or any of the obligations of Tenant be affected or reduced by reason of such interruption,
 curtailment or suspension, nor shall the same constitute an actual or constructive eviction.

 

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(B)    If, by reason of Landlord’s failure to make repairs or replacements required to be made by Landlord pursuant to this Lease (a “Landlord Failure”), the Building HVAC System, the Building electrical system, the Building elevators, or the Building
 plumbing/water system serving the Premises shall become inoperable, and as a result thereof a material portion of the Premises is rendered untenantable and Tenant ceases to use such portion of the Premises for the conduct of its business and such Landlord Failure continues unremedied
 for more than ten (10) consecutive days after Tenant gives written notice to Landlord of the Landlord Failure and the fact that a material portion of the Premises has been rendered untenantable by reason of such Landlord Failure and that Tenant shall have ceased using such portion of the
 Premises for the conduct of its business, then the Fixed Rent shall be abated during the time that such portion remains untenantable and unused by reason of such Landlord Failure after such tenth (10th) day, apportioned according to the rentable area of the Premises so rendered
 untenantable and unused. Nothing contained in this Section 28.2(B) is intended to, or shall be deemed to, make any event described in or contemplated by Articles 13, 14 or 39.2 or any event resulting from an act or omission of Tenant or Persons Within Tenant’s Control a Landlord
 Failure.

Section 28.3    Tenant agrees to abide by all requirements which Landlord may prescribe for the proper protection and functioning of its Building Systems and the furnishing of the Building services. Tenant further agrees to cooperate with Landlord in any conservation effort
 pursuant to a program or procedure promulgated or recommended by ASHRAE or any Requirements.

Section 28.4    (A)    If Landlord shall furnish either gas or steam to the Premises, Landlord shall not be liable in any event to Tenant for any failure or defect in the supply or character of the gas or steam furnished to the Premises by reason of any requirement, act or
 omission of the public utility or other provider serving the Building with steam or for any other reason not attributable solely to Landlord’s willful misconduct or gross negligence. Tenant’s use of gas or steam in the Premises shall not at any time exceed the capacity of any of the gas lines
 and equipment or steam lines and equipment in or otherwise then serving the Premises.

(B)    If Landlord shall furnish gas to the Premises, Landlord shall, at Tenant’s expense, install a meter or meters to measure consumption in the Premises and Tenant shall pay Landlord for the gas consumed at Landlord’s cost.

Section 28.5    Landlord shall have no obligation to clean, repair, replace or maintain any “private” plumbing fixtures or facilities (i.e., plumbing fixtures and facilities other than those that would be the common toilets in a multi-tenant floor) or the rooms in which they are
 located.

Section 28.6    Tenant acknowledges that Landlord may establish a messenger center in the lobby or other public portion of either the Building or another building on the Real Property. In such event, Landlord shall notify Tenant of the establishment, location and hours of
 operation of the messenger center and, thereafter, (i) all deliveries to Tenant shall be made to the messenger center and not to the Premises and (ii) no messenger shall be permitted in the passenger or freight elevators of the Building. Landlord may operate a messenger center consistent
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rules and regulations prescribed by Landlord from time to time. Tenant and Persons Within Tenant’s Control shall comply with such procedures, rules and regulations. Landlord shall not enforce such Rules and Regulations against Tenant in a discriminating manner.

ARTICLE 29

PARTNERSHIP TENANT

Section 29.1    If Tenant is a partnership, or is comprised of two (2) or more persons, individually or as co-partners of a partnership (any such partnership and such persons are referred to in this Article 29 as “Partnership Tenant”), or if Tenant’s interest in this Lease shall be
 assigned to a Partnership Tenant, the following provisions shall apply to such Partnership Tenant: (a) the liability of each of the parties comprising Partnership Tenant shall be joint and several; (b) each of the parties comprising Partnership Tenant hereby consents in advance to, and
 agrees to be bound by (i) any written agreement that may hereafter be executed by Partnership Tenant or any successor entity, changing, extending or discharging this Lease, in whole or in part, or surrendering all or any part of the Premises to Landlord, and (ii) any Notices that may
 hereafter be given by Partnership Tenant or by any of the parties comprising Partnership Tenant; (c) any Notices given or rendered to Partnership Tenant or to any of such parties shall be binding upon Partnership Tenant and all such parties; (d) if Partnership Tenant admits new partners,
 all of such new partners shall, by their admission to Partnership Tenant, be deemed to have assumed joint and several liability for the performance of all of the terms, covenants and conditions of this Lease on Tenant’s part to be observed and performed; (e) Partnership Tenant shall give
 prompt notice to Landlord of the admission of any such new partners, and upon demand of Landlord, shall cause each such new partner to execute and deliver to Landlord an agreement in form satisfactory to Landlord, wherein each such new partner assumes joint and several liability for
 the performance of all the terms, covenants and conditions of this Lease on Tenant’s part to be observed and performed (but neither Landlord’s failure to request any such agreement nor the failure of any such new partner to execute or deliver any such agreement to Landlord shall vitiate
 the provisions of clause (d) of this Article 29); and (f) any present or future partner of Partnership Tenant who is no longer a partner of Partnership Tenant at the time of any default under this Lease shall, nevertheless, remain liable for the obligations of Tenant under this Lease, as if any
 such partner had been a partner of Partnership Tenant on the date of such default.

ARTICLE 30

ELECTRIC ENERGY

Section 30.1    Subject to the provisions of this Article, Landlord shall furnish the electric energy that Tenant shall reasonably require in the Premises for the Permitted Use. Except for electric energy required to operate motors on the air handlers providing heat, ventilating
 and conditioning to the Premises (“HVAC Electric”), such electric energy may, at Landlord’s option, be furnished through a meter or meters and related equipment, installed and maintained by Landlord at Tenant’s expense, measuring the amount of electric energy furnished to the
 Premises. Tenant shall pay Landlord for such electric energy as Additional Rent, within

 

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ten days after Landlord bills Tenant therefor, which bills shall be rendered not more often than monthly. The amount of such Additional Rent (a) for HVAC Electric shall be equal to Landlord’s cost, as determined pursuant to Section 28.1, and (b) for other electric energy furnished to the
 Premises (“Basic Electric”) shall be equal to Landlord’s actual cost, applied to the readings on each such meter or meters, including in each case, without limitation, those charges applicable to or computed on the basis of electric consumption, demand and hours of use, any sales or other
 taxes regularly passed on to or collected from similar consumers by such public utility company, fuel rate adjustments and surcharges, and weighted in each case to reflect differences in consumption or demand applicable to each rate level (taking into account the benefit of any “business
 incentive rate” that is payable by Landlord). Tenant and its authorized representatives may have access to such meter or meters (if any) on at least three days’ notice to Landlord, for the purposes of verifying Landlord’s meter readings (if any). From time to time during the Term of this
 Lease, Landlord may, in its sole discretion, install or eliminate, or increase or reduce the number of, such meters or vary the portions of the Premises which they serve or replace any or all of such meters.

Section 30.2    If pursuant to any Requirements, the charges to Tenant pursuant to Section 30.1 shall be reduced below that to which Landlord is entitled under such Section, the deficiency shall be paid by Tenant within 10 days after being billed therefor, as Additional Rent
 for the use and maintenance of the electric distribution system of the Building.

Section 30.3    Landlord shall not be liable in any event to Tenant for any failure or defect in the supply or character of electric energy furnished to the Premises by reason of any requirement, act or omission of the public utility or other provider serving the Building with
 electric energy or for any other reason not attributable solely to Landlord’s willful misconduct or gross negligence.

Section 30.4    Landlord shall furnish and install all replacement lighting tubes, lamps, bulbs and ballasts required in the Premises, and Tenant shall pay to Landlord or its designated contractor upon demand the then established reasonable charges therefor of Landlord or its
 designated contractor, as the case may be.

Section 30.5    Tenant’s use of electric energy in the Premises shall not at any time exceed the capacity of any of the electrical conductors and equipment in or otherwise serving the Premises. In order to insure that such capacity is not exceeded and to avert possible adverse
 effect upon the Building’s distribution of electricity via the Building’s electric system, Tenant shall not, without Landlord’s prior consent in each instance (which shall not be unreasonably withheld, based upon availability of electric energy in the Building as allocated by Landlord to
 various areas of the Building) make any alterations or additions to the electric system of the Premises existing on the Commencement Date. Should Landlord grant such consent, all additional risers or other equipment required therefor shall be provided by Landlord and the cost thereof
 shall be paid by Tenant to Landlord on demand. Landlord shall have the right to require Tenant to pay sums on account of such cost prior to the installation of any such risers or equipment.

 

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Section 30.6    Landlord, upon at least sixty days’ notice to Tenant, (and after Tenant is able and the Premises are equipped to receive electric energy directly from the utility company, as hereinafter provided), may discontinue Landlord’s provision of electric energy (or either
 HVAC Electric or Basic Electric, as the case may be) hereunder. If Landlord discontinues provision of electric energy pursuant to this Section, Tenant shall not be released from any liability under this Lease, except that as of the date of such discontinuance, Tenant’s obligation to pay
 Landlord Additional Rent under Section 30.1 for electric energy (or either HVAC Electric or Basic Electric, as the case may be) thereafter supplied to the Premises shall cease. As of such date, Landlord shall permit Tenant to receive electric energy directly from the public utility
 company or other provider supplying electric energy to the Project, and Tenant shall pay all costs and expenses of obtaining such direct electrical service. Such electric energy may be furnished to Tenant by means of the then existing Building system feeders, risers and wiring to the
 extent that the same are available, suitable and safe for such purpose. All additional meters and additional panel boards, feeders, risers, wiring and other conductors and equipment which may be required to obtain electric energy directly from such public utility company or other provider
 shall be furnished and installed by Landlord at Landlord’s expense (which, to the extent not already in place, shall constitute an Operating Expense, amortized on a straight line basis over the useful life of the items in question, as reasonably determined by Landlord).

ARTICLE 31

SIGNS

Section 31.1    The location, size, materials, quality, design, color and lettering of any signs desired by Tenant shall be subject to the prior approval of Landlord (not to be unreasonably withheld or delayed) and shall be in compliance with the standards promulgated by
 Landlord. At Landlord’s option, Landlord may install any such signs, and Tenant shall pay all costs associated with such installation, as Additional Rent, within ten (10) days after demand therefor.

ARTICLE 32

BROKER

Section 32.1    Landlord represents and warrants to Tenant that Landlord has not dealt with any broker or Person in connection with this Lease other than the Broker(s). Tenant represents and warrants to Landlord that Tenant has not dealt with any broker or Person in
 connection with this Lease other than the Broker(s). The execution and delivery of this Lease by each party shall be conclusive evidence that such party acknowledges that each party has relied upon the foregoing representation and warranty. Landlord and Tenant each shall indemnify
 and hold harmless the other from and against any and all claims for commission, fee or other compensation by any Person other than the Broker who claims to have dealt with such party in connection with this Lease and for any and all costs incurred by the indemnified party in
 connection with such claims, including, without limitation, reasonable attorneys’ fees and disbursements. Landlord shall indemnify and hold harmless Tenant from and against any and all claims for commission, fee or other compensation by the Broker in connection with this Lease

 

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and for any and all costs incurred by the indemnified party in connection with such claims, including, without limitation, reasonable attorneys’ fees and disbursements. Landlord shall compensate Broker(s) pursuant to a separate agreement between Broker(s) and Landlord, which may
 provide that Emisphere shall compensate Broker(s) pursuant to a separate agreement between Broker(s) and Emisphere for a portion of the commission. This provision shall survive the expiration or earlier termination of this Lease.

ARTICLE 33

INDEMNITY

Section 33.1    Tenant shall not do or permit any act or thing to be done upon the Premises or the Real Property that may subject any Indemnitee to any liability or responsibility for injury, damage to persons or property or to any liability by reason of the existence or
 application of, compliance with or violation of any Requirement, but shall exercise such control over the Premises as to protect each Indemnitee fully against any such liability and responsibility. Tenant shall indemnify and save harmless the Indemnitees from and against (a) all claims of
 whatever nature against the Indemnitees arising from any act, omission or negligence of Tenant or Persons Within Tenant’s Control, (b) all claims against the Indemnitees arising from any accident, injury or damage whatsoever caused to any person or to the property of any person and
 occurring in or about the Premises during the Term or during Tenant’s occupancy of the Premises (unless caused by Landlord’s negligence or willful misconduct), (c) all claims against the Indemnitees arising from any accident, injury or damage occurring outside of the Premises but
 anywhere within or about the Real Property, where such accident, injury or damage results or is claimed to have resulted from an act, omission or negligence of Tenant or Persons Within Tenant’s Control, and (d) any breach, violation or non-performance of any covenant, condition or
 agreement contained in this Lease to be fulfilled, kept, observed and performed by Tenant. This indemnity and hold harmless agreement shall include indemnity from and against any and all liability, fines, suits, demands, costs and expenses of any kind or nature (including, without
 limitation, attorneys’ fees and disbursements) incurred in or in connection with any such claim or proceeding brought thereon, and the defense thereof.

Section 33.2    If any claim, action or proceeding is made or brought against any Indemnitee, against which claim, action or proceeding Tenant is obligated to indemnify such Indemnitee pursuant to the terms of this Lease, then, upon demand by the Indemnitee, Tenant, at its
 sole cost and expense, shall resist or defend such claim, action or proceeding in the Indemnitee’s name, if necessary, by counsel reasonably satisfactory to Landlord. Counsel selected by Tenant’s insurance company shall be deemed satisfactory to Landlord. Notwithstanding the
 foregoing, if such attorneys shall be defending both Tenant or any Persons Within Tenant’s Control and an Indemnitee, such Indemnitee may, if it reasonable determines that there is a potential conflict of interest or the matter involves claims in excess of $3,000,000, retain its own
 attorneys to defend or assist in defending any claim, action or proceeding, and Tenant shall pay the reasonable fees and disbursements of such attorneys. The provisions of this Article 33 shall survive the expiration or earlier termination of this Lease.

 

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ARTICLE 34

PARKING

Section 34.1    Landlord shall, without charge to Tenant (except as consequence of the cost thereof being included in Operating Expenses), provide and maintain, for the non-exclusive use of Tenant’s employees and invitees, parking areas sufficient to accommodate that
 number of standard size automobiles as shall be equal to the Number Parking Spaces set forth in the Reference Page in the area(s) shown on the plan attached hereto as Schedule H. In the event Landlord utilizes such parking areas for Landlord’s development purposes, Landlord will
 provide Tenant with substantially equivalent number of parking facilities.

ARTICLE 35

SECURITY DEPOSIT

Section 35.1    Tenant has deposited with Landlord on the signing of this Lease the Security Deposit by Letter of Credit (as defined and further described in Section 35.2), as security for the faithful performance and observance by Tenant of the terms, provisions and
 conditions of this Lease. Tenant agrees that in the event (i) of the occurrence of an Event of Default or (ii) Tenant has defaulted in the performance of any of its obligations under this Lease, including the payment of any item of Rental, and the transmittal of a Notice of default by
 Landlord is barred by applicable law, Landlord may draw the entire amount of the Letter of Credit and use, apply or retain the whole or any part of such proceeds, to the extent required for the payment of any Fixed Rent, Additional Rent, or any other sum as to which Tenant is in default,
 or for any sum that Landlord may expend or may be required to expend by reason of the default (including any damages or deficiency accrued before or after summary proceedings or other re-entry by Landlord). If Landlord applies or retains any portion or all of the proceeds of the Letter
 of Credit, Tenant shall forthwith restore the amount so applied or retained by delivering an additional or new Letter of Credit so that, at all times, the amount of the Security Deposit shall be the amount set forth on the Reference Page. Provided there is no uncured default, any balance of
 the proceeds of the Letter of Credit held by Landlord and not used, applied or retained by Landlord as above provided, and any remaining Letter of Credit, shall be returned to Tenant after the Expiration Date and after delivery of possession of the entire Premises to Landlord in
 accordance with the terms of this Lease.

Section 35.2    Tenant shall deliver to Landlord a clean, irrevocable and unconditional letter of credit (such letter of credit, and any replacement thereof as provided herein, is called a “Letter of Credit”) issued and drawn upon any commercial bank approved by Landlord with
 offices for banking purposes in the City of New York (“Issuing Bank”), which Letter of Credit shall have a term of not less than one year, be in form and content satisfactory to Landlord, be for the account of Landlord and be in the amount of the Security Deposit set forth in the
 Reference Page. The form of letter of credit annexed to this Lease as Schedule F is satisfactory. The Letter of Credit shall provide that:

 

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(1)    The Issuing Bank shall pay to Landlord or its duly authorized representative an amount up to the face amount of the Letter of Credit upon presentation of the Letter of Credit and a sight draft in the amount to be drawn;

(2)    The Letter of Credit shall be deemed to be automatically renewed, without amendment, for consecutive periods of one year each during the Term, unless the Issuing Bank sends written notice (the “Non-Renewal Notice”) to Landlord by certified
 or registered mail, return receipt requested, at least thirty (30) days prior to the expiration date of the Letter of Credit, to the effect that it elects not to have such Letter of Credit renewed;

(3)    The Letter of Credit delivered in respect of the last year of the Term shall have an expiration date of not earlier than thirty (30) days after the Fixed Expiration Date; and

(4)    The Letter of Credit shall be transferable by Landlord as provided in Section 35.4.

Section 35.3    Landlord, after receipt of the Non-Renewal Notice, shall have the right to draw the entire amount of the Letter of Credit and to hold the proceeds as a cash Security Deposit. Landlord shall release such proceeds to Tenant upon delivery to Landlord of a
 replacement Letter of Credit complying with the terms hereof.

Section 35.4    In the event of the sale or lease of the Building or the Real Property, Landlord shall have the right to transfer the Security Deposit, without charge for such transfer, to the purchaser or lessee, and Landlord shall thereupon be released by Tenant from all liability
 for the return of such Security Deposit. In such event, Tenant agrees to look solely to the new Landlord for the return of said Security Deposit. It is agreed that the provisions hereof shall apply to every transfer or assignment made of the Security Deposit to a new Landlord. Tenant shall
 execute such documents as may be necessary to accomplish such transfer or assignment of the Letter of Credit.

Section 35.5    Tenant covenants that it will not assign or encumber, or attempt to assign or encumber, the Security Deposit held hereunder, and that neither Landlord nor its successors or assigns shall be bound by any such assignment, encumbrance, attempted assignment, or
 attempted encumbrance. In the event that any bankruptcy, insolvency, reorganization or other debtor-creditor proceedings shall be instituted by or against Tenant, its successors or assigns, or any guarantor of Tenant hereunder, the security shall be deemed to be applied to the payment of
 the Fixed Rent and Additional Rent due Landlord for periods prior to the institution of such proceedings and the balance, if any, may be retained by Landlord in partial satisfaction of Landlord’s damages.

Section 35.6    Provided that Tenant is not then in default under the terms of the Lease, Tenant shall be permitted, after August 31, 2012 (or such earlier date that the Furniture Payments are no longer due), to reduce the Security Deposit by $50,000. To accomplish such
 reduction, Landlord agrees to accept a simultaneous exchange of the existing Letter of Credit held by Landlord for a replacement Letter of Credit in an amount $50,000 less than the existing Letter of Credit. Tenant shall be liable for all fees and expenses incurred in obtaining such
 replacement Letter of Credit.

 

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ARTICLE 36

RENT REGULATION

Section 36.1    If at any time or times during the Term of this Lease, the Rental reserved in this Lease is not fully collectible by reason of any Requirement, Tenant shall enter into such agreements and take such other steps (without additional expense to Tenant) as Landlord
 may request and as may be legally permissible to permit Landlord to collect the maximum rents that may from time to time during the continuance of such legal rent restriction be legally permissible (and not in excess of the amounts reserved under this Lease). Upon the termination of
 such legal rent restriction (a) the Rental shall become and thereafter be payable hereunder in accordance with the amounts reserved in this Lease for the remainder of the Term, and (b) Tenant shall pay to Landlord, if legally permissible, an amount equal to (i) the items of Rental that
 would have been paid pursuant to this Lease but for such legal rent restriction less (ii) the rents paid by Tenant to Landlord during the period or periods such legal rent restriction was in effect. This provision shall survive the expiration or earlier termination of this Lease to the maximum
 enforceable extent.

ARTICLE 37

ALTERNATIVE SPACE

Section 37.1    In the event that at any time prior to October 23, 2003, Tenant shall have the right to terminate this lease with respect to the Space B Premises upon notice to Landlord, whereupon the Space B Premises shall be deemed deleted from this Lease, the Fixed Rent,
 Tenant’s Tax Proportionate Share and Operating Expense Proportionate Share shall be reduced ratably based on the number of square feet in the Space B Premises versus the entire Premises. Upon the termination of this Lease with respect to the Space B Premises, Landlord and Tenant
 shall promptly enter into an amendment of this Lease memorializing such partial termination and reduction of the Premises; provided, however, that the parties failure for any reason to execute and deliver such amendment shall not effect the termination of this Lease as to the Space B
 Premises as aforesaid.

ARTICLE 38

COVENANT OF QUIET ENJOYMENT

Section 38.1    Landlord covenants that, upon Tenant paying the Fixed Rent and Additional Rent and observing and performing all the terms, agreements, covenants, provisions and conditions of this Lease on Tenant’s part to be observed and performed, Tenant may
 peaceably and quietly enjoy the Premises, and provided further that this covenant shall bind and

 

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be enforceable against Landlord or any successor to Landlord’s interest, subject to the terms hereof, only so long as Landlord or any successor to Landlord’s interest, is in possession and is collecting rent from Tenant but not thereafter.

ARTICLE 39

MISCELLANEOUS

Section 39.1    This Lease is presented for signature by Tenant and it is understood that this Lease shall not constitute an offer by or be binding upon Landlord unless and until Landlord shall have executed and delivered a fully executed copy of this Lease to Tenant.

Section 39.2    The obligations of Landlord under this Lease shall not be binding upon Landlord named herein after the sale, conveyance, assignment or transfer by such Landlord (or upon any subsequent landlord after the sale, conveyance, assignment or transfer by such
 subsequent landlord) of its interest in the Building or the Real Property, as the case may be, and in the event of any such sale, conveyance, assignment or transfer, Landlord shall be and hereby is entirely freed and relieved of all covenants and obligations of Landlord under this Lease
 thereafter arising, and the transferee shall be deemed to have assumed, subject to the remaining provisions of this Section 39.2, all obligations of the Landlord under this Lease arising after the effective date of the transfer. No member, trustee, partner, shareholder, director or officer of
 Landlord, or of any partner or shareholder of Landlord (collectively, the “Parties”) shall have any direct or personal liability for the performance of Landlord’s obligations under this Lease, and Tenant shall look solely to Landlord’s interest in the Real Property to enforce Landlord’s
 obligations hereunder and shall not otherwise seek any damages against Landlord personally or any of the Parties whatsoever. Tenant shall not look to any other property or assets of Landlord or any property or assets of any of the Parties in seeking either to enforce Landlord’s
 obligations under this Lease or to satisfy a judgment for Landlord’s failure to perform such obligations.

Section 39.3    Notwithstanding anything contained in this Lease to the contrary, all amounts payable by Tenant to or on behalf of Landlord under this Lease, whether or not expressly denominated Fixed Rent, Additional Rent or Rental, shall constitute rent for the purposes of
 Section 502(b)(7) of the Bankruptcy Code.

Section 39.4    Neither this Lease nor any memorandum of this Lease shall be recorded. Notwithstanding the foregoing, in the event that Tenant is unable to record the subordination, nondisturbance and attornment agreement between Tenant and the Mortgagee without first
 recording a memorandum of this Lease, Tenant shall be permitted, at its sole cost and expense, to record a memorandum of this Lease in a form reasonably approved by Landlord, provided that Tenant deliver to Landlord, simultaneously with the delivery of such memorandum, a
 termination and release of such memorandum which is in recordable form and is executed and notarized by an authorized officer of Tenant.

Section 39.5    Except as otherwise expressly stated in this Lease, any consent or approval required to be obtained from Landlord may be granted by Landlord in its sole discretion. In any instance in which Landlord agrees not to act unreasonably, Tenant hereby

 

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waives any claim for damages against or liability of Landlord that Tenant may have based upon any assertion that Landlord has unreasonably withheld or unreasonably delayed any consent or approval requested by Tenant, and Tenant agrees that its sole remedy shall be an action or
 proceeding to enforce any related provision or for specific performance, injunction or declaratory judgment, provided that, the successful party in any such action shall be entitled to recover its costs and expenses, including reasonable attorneys’ fees and expenses. If with respect to any
 required consent or approval Landlord is required by the express provisions of this Lease not to unreasonably withhold or delay its consent or approval, and if it is determined in any such proceeding referred to in the preceding sentence that Landlord acted unreasonably, the requested
 consent or approval shall be deemed to have been granted; however, Landlord shall have no liability whatsoever to Tenant for its refusal or failure to give such consent or approval. Tenant’s sole remedy for Landlord’s unreasonably withholding or delaying consent or approval shall be as
 provided in this Section 39.5.

Section 39.6    Notwithstanding anything contained in this Lease or indicated on any sketch, blueprint or plan, any vaults, vault space or other space outside the boundaries of the Real Property are not included in the Premises. Landlord makes no representation as to the
 location of the boundaries of the Real Property. All vaults and vault space and all other space outside the boundaries of the Real Property which Tenant may be permitted to use or occupy are to be used or occupied under a revocable license, and if any such license is revoked, or if the
 amount of such space is diminished or required by any Government Authority or by any public utility company, such revocation, diminution or requisition shall not constitute an actual or constructive eviction, in whole or in part, or entitle Tenant to any abatement or diminution of
 Rental, or relieve Tenant from any of its obligations under this Lease, or impose any liability upon Landlord. Any fee, tax or charge imposed by any Government Authority for any such vaults, vault space or other space occupied by Tenant shall be paid by Tenant.

Section 39.7    If
    Tenant shall remain in possession of the Premises after the Expiration Date,
    without the execution by both Tenant and Landlord of a new lease, Tenant,
    at the election of Landlord, shall be deemed to be occupying the Premises
    as a Tenant from month-to-month, at a monthly rental equal to the greater
    of (a) one and one-half (11/2) times the Rental payable during the last month
    of the Term, and (b) the then fair market value, on a monthly basis, for
    comparable space, subject to all the other conditions, provisions and obligations
    of this Lease  insofar as the same are applicable to a month-to-month tenancy.

Section 39.8    This Lease shall be construed without regard to any presumption or other rule requiring construction against the party causing this Lease to be drafted. If any words or phrases in this Lease are stricken out or otherwise eliminated, whether or not any other words
 or phrases have been added, this Lease shall be construed as if the words or phrases so stricken out or otherwise eliminated were never included in this Lease and no implication or inference shall be drawn from the fact that such words or phrases were stricken out or otherwise eliminated.

Section 39.9    If any of the provisions of this Lease, or the application thereof to any person or circumstance, shall, to any extent, be invalid or unenforceable, the remainder of this Lease, or the application of such provisions to persons or circumstances other than those as to
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valid and enforceable, and every provision of this Lease shall be valid and enforceable to the fullest extent permitted by law.

Section 39.10    Landlord shall have the right to erect any gate, chain or other obstruction or to close off any portion of the Real Property to the public at any time to the extent necessary to prevent a dedication thereof for public use.

Section 39.11    Tenant hereby represents to Landlord that it is not entitled, directly or indirectly, to diplomatic or sovereign immunity and Tenant agrees that in all disputes arising directly or indirectly out of this Lease Tenant shall be subject to service of process in, and the
 jurisdiction of the courts of, the State of New York. The provisions of this Section 39.11 shall survive the expiration of this Lease.

Section 39.12    This Lease contains the entire agreement between the parties and all prior negotiations and agreements related to the Premises are merged into this Lease. This Lease may not be changed, abandoned or discharged, in whole or in part, nor may any of its
 provisions be waived except by a written agreement that (a) expressly refers to this Lease, and (b) is executed by the party against whom enforcement of the change, abandonment, discharge or waiver is sought.

Section 39.13    Any apportionment or prorations of Rental to be made under this Lease shall be computed on the basis of the calendar year or month as applicable.

Section 39.14    This Lease shall be governed by the laws of the State of New York, without regard to conflict of laws principles.

Section 39.15    If Tenant is a corporation or a limited liability company, each person executing this Lease on behalf of Tenant hereby covenants, represents and warrants that Tenant is duly incorporated, duly formed or duly qualified (if foreign), is in good standing and is
 authorized to do business in the State of New York (a copy of evidence thereof to be supplied to Landlord upon request); and that each person executing this Lease on behalf of Tenant is an officer or member of Tenant and that he or she is duly authorized to execute, acknowledge and
 deliver this Lease to Landlord (a copy of a resolution or other evidence to that effect to be supplied to Landlord upon request).

Section 39.16    The captions are inserted only as a matter of convenience and for reference and in no way define, limit or describe the scope of this Lease nor the intent of any provision thereof.

Section 39.17    The covenants, conditions and agreements contained in this Lease shall bind and inure to the benefit of Landlord and Tenant and their respective legal representatives, successors, and, except as otherwise provided in this Lease, their assigns.

Section 39.18    There shall be no postponement of the Commencement Date for any delay in the delivery of possession of the Premises which results from any act or omission of Tenant (or Persons within Tenant’s Control), including delays due to changes in or additions to,
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plans or information approving working drawings or estimates or giving authorizations or approvals.

Section 39.19    For the purposes of this Lease and all agreements supplemental to this Lease, unless the context otherwise requires:

	 	            (a)    The words “herein”, “hereof”, “hereunder” and “hereby” and words of similar import shall be construed to refer to this Lease as a whole and not to any particular Article or Section unless expressly so stated.

	 	 
	 	            (b)    Tenant’s obligations hereunder shall be construed in every instance as conditions as well as covenants, each separate and independent of any other terms of this Lease.

	 	 
	 	            (c)    Reference to Landlord as having “no liability” or being “without liability” shall mean that Tenant shall not be entitled to terminate this Lease, or to claim actual or constructive eviction, partial or total, or to receive any abatement or diminution of rent, or to
 be relieved in any manner of any of its other obligations hereunder, or to be compensated for loss or injury suffered or to enforce any other right or liability whatsoever against Landlord under or with respect to this Lease or with respect to Tenant’s use or occupancy of the
 Premises.

	 	 
	 	            (d)    Reference to “termination of this Lease” or “expiration of this Lease” and words of like import includes expiration or sooner termination of this Lease and the Term and the estate hereby granted or cancellation of this Lease pursuant to any of the provisions
 of this Lease or to law. Upon the termination of this Lease, the Term and estate granted by this Lease shall end at noon on the date of termination as if such date were the Fixed Expiration Date, and neither party shall have any further obligation or liability to the other after
 such termination except (i) as shall be expressly provided for in this Lease, and (ii) for such obligations as by their nature under the circumstances can only be, or by the provisions of this Lease, may be, performed after such termination, and, in any event, unless expressly
 otherwise provided in this Lease, any liability for a payment (which shall be apportioned as of such termination) which shall have accrued to or with respect to any period ending at the time of termination shall survive the termination of this Lease.

	 	 
	 	            (e)    Words and phrases used in the singular shall be deemed to include the plural and vice versa, and nouns and pronouns used in any particular gender shall be deemed to include any other gender.

	 	 
	 	            (f)    The rule of “ejusdem generis” shall not be applicable to limit a general statement following or referable to an enumeration of specific matters to matters similar to the matters specifically mentioned.

Section 39.20    If an excavation shall
    be made upon land adjacent to the Building, or shall be authorized to be
    made, Tenant shall, upon reasonable advance notice, afford to the person
    causing or authorized to cause such excavation, license to enter upon the
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purpose of doing such work as said person shall deem necessary to preserve the walls of the Building from injury or damage and to support the same by proper foundations without any claim for eviction or constructive eviction, damages or indemnity against Landlord, or diminution or
 abatement of Rental. In the event Landlord is required to enter the Premises as provided in this Section, Landlord shall use reasonable efforts to minimize interference with Tenant’s use and occupancy of the Premises and shall, except in the case of an emergency, attempt to coordinate
 with Tenant prior to entering the Premises and performing any work; provided, however, that Landlord shall have no obligation to employ contractors or labor at so-called overtime or other premium pay rates or to incur any other overtime costs in connection with such work.

ARTICLE 40

EXISTING FURNITURE AND IMPROVEMENTS

Section 40.1    Emisphere has agreed to permit Tenant to use certain of the existing furniture, equipment and improvements located in the Space A Premises, as such items are listed on Exhibit E attached hereto and made in part hereof (collectively, the “Furniture”). A
 portion of the Fixed Rent payable hereunder, as shown on Schedule I attached hereto, is attributable to the use of the Furniture.

ARTICLE 41

APPROVAL CONTINGENCY

Section 41.1    This Lease shall not be effective unless and until approved or deemed approved by CDC Mortgage Capital Inc. (“CDC”) and Greenwich Capital Financial Products, Inc. (each a “Lender”). If Lender disapproves this Lease, Landlord shall give notice to Tenant
 of such disapproval, and thereupon, this Lease shall be deemed null and void and of no effect, except Landlord shall return to Tenant any security deposit and prepaid rent paid by Tenant to Landlord (but only to the extent Tenant has not occupied the Premises for the period of time for
 which the prepaid rent was intended to cover). Any such approval in accordance with the provisions of this Article 41 shall be deemed retroactive to the Commencement Date. Notwithstanding any provision to the contrary, if Tenant occupies the Premises or causes any work to be
 performed thereon prior to receipt of each Lender’s approval or disapproval, then as between Tenant and Landlord the provisions of this Lease shall be applicable and enforceable. In the event either Lender is not the holder of a mortgage on the Project at the time Landlord signs and
 delivers this Lease to Tenant, then such Lender’s approval shall not be required (unless Landlord is otherwise bound to obtain such approval).

 

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ARTICLE 42

REIMBURSEMENT FOR RELOCATION OF COMMON CONFERENCE ROOM

Section 42.1    The Space B Premises is currently being used as a conference room (the “Conference Room”) as part of the common area of the Spine Building. Landlord has agreed to relocate the Conference Room to a different location within the Spine Building in order to
 make the Space B Premises available for Tenant’s use as part of the Premises. Tenant agrees to reimburse Landlord for the actual cost (plus interest at 8% per annum) of relocating the Conference Room, but such reimbursement shall not be in excess of the principal amount of $100,000.
 Upon completion of the relocation of the Conference Room, Landlord shall deliver to Tenant evidence of Landlord’s actual cost of relocating the Conference Room (the “Relocation Cost”). Commencing on the first day of the month following such notice to Tenant and thereafter on the
 first day of each and every calendar month during the initial Term, Tenant shall pay to Landlord equal monthly installments aggregating the amount necessary, as calculated by Landlord, to amortize fully over the period remaining in the initial Term, the Relocation Cost, together with
 interest thereon at the rate of 8.0% per annum.

ARTICLE 43

RENEWAL OPTIONS

Section 43.1    Provided that (a) this Lease is in full force and effect as of the date of the First Renewal Notice (as hereinafter defined) and the Second Renewal Notice (as hereinafter defined), as the case may be, (b) there shall not then be existing an Event of Default
 hereunder and (c) Tenant shall be in actual physical occupancy of at least 50% of the Premises on the date of the applicable Renewal Notice and upon commencement of the applicable Renewal Term, Tenant shall have two options to extend the Term of this Lease, each for an additional
 term of five years (respectively, the “First Renewal Term” and the “Second Renewal Term” and collectively, the “Renewal Terms”), commencing on the day after the Fixed Expiration Date, in the case of the First Renewal Term, and commencing on the day after the last day of the First
 Renewal Term, in the case of the Second Renewal Term. Notwithstanding the preceding sentence, Landlord, in its sole discretion, may waive any Event of Default by Tenant and no such Event of Default may be used by Tenant to negate the effectiveness of Tenant’s exercise of the
 option(s) hereunder. Tenant’s option with respect to the First Renewal Term shall be exercisable by written notice (the “First Renewal Notice”) to Landlord given not later than twelve (12) months prior to the Fixed Expiration Date. Tenant’s option with respect to the Second Renewal
 Term, shall be exercisable by written notice (the “Second Renewal Notice”) to Landlord given not later than twelve (12) months prior to the last day of the First Renewal Term. The Renewal Terms shall constitute extensions of the initial Term of this Lease and shall be upon all of the
 same terms and conditions as the initial Term, except that (i) there shall be only one option to renew the term of this Lease for the Second Renewal Term in the First Renewal Term, and there shall be no further option to renew the term of this Lease in the Second Renewal Term, (ii)
 Landlord shall not be required to furnish any materials or perform any work to prepare the Premises for Tenant’s occupancy and Landlord shall not be required to reimburse Tenant for any

 

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Alterations made or to be made by Tenant, and (iii) the Fixed Rent for the Renewal Terms shall be payable at a rate per annum equal to the fair market rental value of the Premises as of the first day of the First Renewal Term in the case of the First Renewal Term, and as of the first day of
 the Second Renewal Term in the case of the Second Renewal Term. During both Renewal Terms, all sums of Additional Rent that Tenant is obligated to pay under this Lease during the initial Term shall continue without interruption, it being the intention of the parties hereto that the
 Renewal Terms shall be deemed a part of and continuation of the initial Term of this Lease.

Section 43.2    If Tenant shall have given the First Renewal Notice or the Second Renewal Notice, as the case may be, in accordance with Section 43.1 of this Article 43, the parties shall endeavor to agree upon the fair market rental value of the Premises, as of the first day of
 each Renewal Term. In determining fair market rental value, the parties shall take into account all relevant factors and the Premises shall be deemed to have Building standard improvements, notwithstanding that Tenant may have installed above standard improvements. In the event that
 the parties are unable to agree upon such fair market value for either Renewal Term within thirty (30) days after the giving of the First Renewal Notice or the Second Renewal Notice as the case may be, then Tenant shall have the right to void the First Renewal Notice or Second Renewal
 Notice, as the case may be, upon notice to Landlord, or if Tenant does not so void such notice then either party may request that the same be determined as follows: A senior officer of a nationally recognized leasing brokerage firm with local knowledge of Westchester County real estate
 and knowledge of the greater New York laboratory / research and development leasing market (the “Baseball Arbitrator”) shall be selected and paid for jointly by Landlord and Tenant. If Landlord and Tenant are unable to agree upon the Baseball Arbitrator, then the same shall be
 designated by the Manhattan Chapter of the American Arbitration Association or any successor organization thereto (the “AAA”). The Baseball Arbitrator selected by the parties or designated by the President of the AAA shall (i) have at least ten years experience in the leasing of office
 and laboratory / research and development space in Westchester County and (ii) not have been employed or retained by either Landlord or Tenant or any affiliate of either for a period of at least 10 years prior to his/her appointment pursuant hereto. Landlord and Tenant shall each submit
 to the Baseball Arbitrator and to the other its determination of the fair market rental value. The Baseball Arbitrator shall afford to Landlord and Tenant a hearing and the right to submit evidence. The Baseball Arbitrator shall determine which of the two rent determinations more closely
 represents the fair market rental value of the Premises. The arbitrator may not select any other fair market rental value for the Premises other than one submitted by Landlord or Tenant. The determination of the party so selected or designated shall be binding upon Landlord and Tenant
 and shall serve as the basis for the determination of the Fixed Rent payable for the applicable Renewal Term. If, as of the commencement date of the applicable Renewal Term, the amount of the Fixed Rent payable during the applicable Renewal Term in accordance with this Article 43
 shall not have been determined, then, pending such determination, Tenant shall pay Fixed Rent equal to the Fixed Rent payable in respect of the last year of the Initial Term in the case of the First Renewal Term and in the last year of the First Renewal Term in the case of the Second
 Renewal Term. After the final determination of the Fixed Rent payable for such Renewal Term, the parties promptly and appropriately shall adjust rental payments theretofore made during the applicable Renewal Term and shall execute a written agreement specifying the amount of the
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determined. Any failure of the parties to execute such written agreement shall not affect the validity of the Fixed Rent as so determined.

Section 43.3    It is an express condition of the options granted to Tenant pursuant to the terms of this Article 43 that time is of the essence with respect to Tenant’s exercise of such options within the periods above provided.

SIGNATURES ON NEXT PAGE

 

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IN WITNESS WHEREOF, Landlord and Tenant have duly executed this Lease as of the day and year first above written.

	 	EASTVIEW HOLDINGS LLC, Landlord

	 	  
	 	 
	 	By:	EASTVIEW SPE INC., its Managing Member

    
	 	 	 
	 	 	 
	 	 	By:	/s/ David W. Klock
	 	 	

	 	 	 	Name: David W. Klock
	 	 	 	Title: Senior Vice President
	 	 	 	 
	 	 	 	 
	 	PROGENICS PHARMACEUTICALS, INC.,
    Tenant
	 	 	 	 
	 	 	 	 
	 	By:	/s/ Robert A. McKinney
	 	

	 	 	Name: Robert A. McKinney
	 	 	Title: Vice President

 

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      SCHEDULE A- I

FLOOR PLAN OF A PORTION OF SPACE A PREMISES (Spine)

FLOOR PLAN OF SPACE C PREMISES

FLOOR PLAN OF SPACE D PREMISES

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SCHEDULE A-2 

FLOOR PLAN OF A PORTION OF SPACE
    A PREMISES (Linde) 

[to be inserted]

 

A-2

 
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SCHEDULE A-3 

FLOOR PLAN OF SPACE
  B PREMISES

 [to be inserted]

 

 

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SCHEDULE B

THE BUILDING

[to be inserted]

[FOLLOWS THIS PAGE]

 

ALL AREAS, DIMENSIONS AND CONDITIONS ARE APPROXIMATE

 

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SCHEDULE C

RULES AND REGULATIONS

1.    The rights of each tenant in the entrances, corridors and elevators servicing the Building are limited to ingress to and egress from such tenant’s premises for the tenant and its employees, licensees and invitees, and no tenant shall use, or permit the use of, the entrances,
 corridors or elevators for any other purpose. No tenant shall invite to the tenant’s premises, or permit the visit of, persons in such numbers or under such conditions as to interfere with the use and enjoyment of any of the plazas, entrances, corridor, elevators and other facilities of the
 Building by any other tenants. Fire exits and stairways are for emergency use only, and they shall not be used for any other purpose by the tenants, their employees, licensees or invitees. No tenant shall encumber or obstruct, or permit the encumbrance or obstruction of any of the
 sidewalks, plazas, entrances, corridors, elevators, fire exits or stairways of the Building. Landlord reserves the right to control and operate the public portions of the Building and the public facilities, as well as facilities furnished for the common use of the tenants, in such manner as it in
 its reasonable judgment deems best for the benefit of the tenants generally.

2.    Landlord may refuse admission to the Building outside of Business Hours on Business Days (as such terms are defined in the lease to which this Schedule is attached) to any person not known to the watchman in charge or not having a pass issued by Landlord or the
 tenant whose premises are to be entered or not otherwise properly identified, and Landlord may require all persons admitted to or leaving the Building outside of Business Hours on Business Days to provide appropriate identification. Landlord will supply identification cards and be
 reimbursed by Tenant at Landlord’s cost plus 5%. Tenant shall be responsible for all persons for whom it issues any such pass and shall be liable to Landlord for all acts or omissions of such persons. Tenant shall promptly notify Landlord in writing of any lost identification cards and will
 reimburse Landlord at cost plus 5% for replacement of identification cards. Any person whose presence in the Building at any time shall, in the judgment of Landlord, be prejudicial to the safety, character or reputation of the Building or of its tenants may be denied access to the Building
 or may be ejected therefrom. During any invasion, riot, public excitement or other commotion, Landlord may prevent all access to the Building by closing the doors or otherwise for the safety of the tenants and protection of property in the Building.

3.    No tenant shall obtain or accept for use in its premises towels, barbering, bootblacking, floor polishing, cleaning or other similar services from any persons reasonably prohibited by Landlord in writing from furnishing such services. Such services shall be furnished only
 at such hours, and under such reasonable regulations, as may be fixed by Landlord from time to time.

4.    The cost of repairing any damage to the public portions of the Building or the public facilities or to any facilities used in common with other tenants, caused by a tenant or its employees, agents, contractors, licensees or invitees, shall be paid by such tenant.

5.    No awnings or other projections shall be attached to the outside walls of the Building. No curtains, blinds, shades or screens which are different from the standards adopted by Landlord for the Building shall be attached to or hung in, or used in connection with, any

 

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exterior window or door of the premises of any tenant, without the prior written consent of Landlord. Such curtains, blinds, shades or screens must be of a quality, type, design and color, and attached in the manner approved by Landlord.

6.    No lettering, sign, advertisement, notice or object shall be displayed in or on the exterior windows or doors, or on the outside of any tenant’s premises, or at any point inside any tenant’s premises where the same might be visible outside of such premises, without the prior
 written consent of Landlord. In the event of the violation of the foregoing by any tenant, Landlord may remove the same without any liability, and may charge the expense incurred in such removal to the tenant violating this rule. Interior signs, elevator cab designations and lettering on
 doors and the Building directory shall, if and when approved by Landlord, be inscribed, painted or affixed for each tenant by Landlord at the expense of such tenant, and shall be of a size, color and style acceptable to Landlord.

7.    The sashes, sash doors, skylights, windows and doors that reflect or admit light and air into the halls, passageways or other public places in the Building shall not be covered or obstructed by any tenant, nor shall any bottles, parcels or other articles be placed on the
 window sills or on the peripheral air conditioning enclosures, if any.

8.    No showcases or other articles shall be put in front of or affixed to any part of the exterior of the Building, nor placed in the halls, corridors or vestibules.

9.    No noise, including, but not limited to, music or the playing of musical instruments, recordings, radio or television, which, in the judgment of Landlord, might disturb other tenants in the Building, shall be made or permitted by any tenant. Nothing shall be done or
 permitted in the premises of any tenant which would impair or interfere with the use or enjoyment by any other tenant of any other space in the Building.

10.    Additional locks or bolts of any kind which shall not be operable by the Grand Master Key for the Building shall not be placed upon any of the doors or windows by any tenant, nor shall any changes be made in locks or the mechanism thereof which shall make such
 locks inoperable by said Grand Master Key. Additional keys for a tenant’s premises and toilet rooms shall be procured only from Landlord who may make a reasonable charge therefor. Each tenant shall, upon the termination of its tenancy, turn over to Landlord all keys of stores, offices
 and toilet rooms, either furnished to, or otherwise procured by, such tenant, and in the event of the loss of any keys furnished by Landlord, such tenant shall pay to Landlord the cost thereof.

11.    All removals, or the carrying in or out of any safes, freight, furniture, packages, boxes, crates or any other object or matter of any description must take place during such hours and in such elevators, and in such manner as Landlord or its agent may determine from time
 to time. The persons employed to move safes and other heavy objects shall be reasonably acceptable to Landlord and, if so required by law, shall hold a Master Rigger’s license. Arrangements will be made by Landlord with any tenant for moving large quantities of furniture and
 equipment into or out of the Building. All labor and engineering costs incurred by Landlord in connection with any moving specified in this rule, including a reasonable charge for overhead and profit, shall be paid by tenant to Landlord, on demand.

 

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12.    Landlord reserves the right to inspect all objects and matter to be brought into the Building and to exclude from the Building all objects and matter which violate any of these Rules and Regulations or the lease of which this Schedule is a part. Landlord may require any
 person leaving the Building with any package or other object or matter to submit a pass, listing such package or object or matter, from the tenant from whose premises the package or object or matter is being removed, but the establishment and enlargement of such requirement shall not
 impose any responsibility on Landlord for the protection of any tenant against the removal of property from the premises of such tenant. Landlord shall in no way be liable to any tenant for damages or loss arising from the admission, exclusion or ejection of any person to or from the
 premises or the Building under the provisions of this Rule or of Rule 2 hereof.

13.    No tenant shall occupy or permit any portion of its premises to be occupied as an office for a public stenographer or public typist, or for the storage, manufacture, or sale of liquor, narcotics, dope, tobacco in any form, or as a barber, beauty or manicure shop, or as a
 school. No tenant shall use or permit its premises or any part thereof to be used for manufacturing or the sale at retail or auction of merchandise, goods or property of any kind.

14.    Landlord shall have the right to prohibit any advertising or identifying sign by any tenant which, in Landlord’s reasonable judgment, tends to impair the reputation of the Building or its desirability as a building for others, and upon written notice from Landlord, such
 tenant shall refrain from and and discontinue such advertising or indentifying sign.

15.    Landlord shall have the right to prescribe the weight and position of safes and other objects of excessive weight, and no safe or other object whose weight exceeds the lawful load for the area upon which it would stand shall be brought into or kept upon any tenant’s
 premises. If, in the judgment of Landlord, it is necessary to distribute the concentrated weight of any heavy object, the work involved in such distribution shall be done at the expense of the tenant and in such manner as Landlord shall determine.

16.    No machines or mechanical equipment shall be placed or operated as to disturb other tenants. All machines and mechanical equipment which are installed and used in a tenant’s premises shall be so equipped, installed and maintained by such tenant as to prevent any
 disturbing noise, vibration or electrical or other interference from being transmitted from such premises to any other area of the Building.

17.    Landlord, its contractors, and their respective employees, shall have the right to use, without charge therefor, all light, power and water in the premises of any tenant while cleaning or making repairs or alterations in the premises of such tenant.

18.    No premises of any tenant shall be used for lodging or sleeping or for any immoral or illegal purpose.

19.    The requirements of tenants will be attended to only upon application at the office of the Building. Employees of Landlord shall not perform any work or do anything outside of their regular duties, unless under special instructions from Landlord.

20.    Canvassing, soliciting and peddling in the Building are prohibited and each tenant shall cooperate to prevent the same.

 

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21.    No tenant shall cause or permit any unusual or objectionable odors to emanate from its premises which would annoy other tenants or create a public or private nuisance. No cooking shall be done in the premises of any tenant except as is expressly permitted in such
 tenant’s lease.

22.    Nothing shall be done or permitted in any tenant’s premises, and nothing shall be brought into or kept in any tenant’s premises, which would impair or interfere with any of the Building’s services or the proper and economic heating, ventilating, air conditioning,
 cleaning or other servicing of the Building or the premises, or the use or enjoyment by any other tenant of any other premises, nor shall there be installed by any tenant any ventilating, air-conditioning, electrical or other equipment of any kind which, in the reasonable judgment of
 Landlord, might cause any such impairment or interference.

23.    No acids, vapors or other materials shall be discharged or permitted to be discharged into the waste lines, vents or flues of the Building which may damage them. The water and wash closets and other plumbing fixtures in or serving any tenant’s premises shall not be
 used for any purpose other than the purposes for which they were designed or constructed, and no sweepings, rubbish, rags, acids or other foreign substances shall be deposited therein. All damages resulting from any misuse of the fixtures shall be borne by the tenant who, or whose
 servants, employees, agents, visitors or licensees shall have, caused the same. Any cuspidors or containers or receptacles used as such in the premises of any tenant or for garbage or similar refuse, shall be emptied, cared for and cleaned by and at the expense of such tenant.

24.    All entrance doors in each tenant’s premises shall be left locked and all windows shall be left closed by the tenant when the tenant’s premises are not in use. Entrance doors shall not be left open at any time. Each tenant, before closing and leaving its premises at any
 time, shall turn out all lights.

25.    Hand trucks not equipped with rubber tires and side guards shall not be used within the Building.

26.    All windows in each tenant’s premises shall be kept closed, and all blinds therein above the ground floor shall be lowered as reasonably required because of the position of the sun, during the operation of the Building air-conditioning system to cool or ventilate the
 tenant’s premises. If Landlord shall elect to install any energy saving film on the windows of any premises or to install energy saving windows in place of the present windows, each tenant shall cooperate with the reasonable requirements of Landlord in connection with such installation
 and thereafter the maintenance and replacement of the film and/or windows and permit Landlord to have access to the tenant’s premises at reasonable times during Business Hours to perform such work.

27.    Landlord reserves the right to rescind, alter or waive any rule or regulation at any time prescribed for the Building when, in its reasonable judgment, it deems it necessary, desirable or proper for its best interest and for the best interests of the tenants generally, and no
 alteration or waiver of any rule or regulation in favor of one tenant shall operate as an alteration or waiver in favor of any other tenant. Landlord shall not be responsible to any tenant for the

 

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nonobservance or violation by any other tenant of any of the rules and regulations at any time prescribed for the Building.

 

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SCHEDULE D

Cleaning Specifications

	A.	TRASH
	 	 	 	 	 
	 	Daily:
	 	1.	 	Deposit all trash in designated area.	 
	 	 	 	 	 	 	 
	B.	ELEVATORS
	 	 	 	 	 
	 	Daily:
	 	1.	 	Damp mop tile floors or vacuum carpets.	 
	 	 	 	2.	 	Spot clean walls, doors and fixtures.	 
	 	Weekly:
	 	1.	 	Spray/buff tile floors.	 
	 	 	 	 	 	 	 
	C.	STAIRWAYS AND LANDINGS
	 	 	 	 	 
	 	Daily:
	 	1.	 	Sweep steps and landing, dust railing.	 
	 	Weekly:
	 	1.	 	Damp mop stairs, tile and concrete.	 
	 	Monthly:
	 	1.	 	Spot clean walls and doors.	 
	 	 	 	 	 	 	 
	D.	CORRIDORS
	 	 	 	 	 
	 	Daily:
	 	1.	 	Dry sweep.	 
	 	 	 	2.	 	Clean and polish water fountains.	 
	 	 	 	3.	 	Clean slop sinks.	 
	 	 	 	4.	 	Vacuum carpets.	 
	 	 	 	5.	 	Spot mop concrete and tile floors	 
	 	Weekly:
	 	1.	 	Spray/buff tile floors.	 
	 	 	 	2.	 	Mop concrete floors.	 
	 	Quarterly:
	 	1.	 	Machine scrub and wax tile floors.	 
	 	Semi-Annually:
	 	1.	 	Shampoo carpets.	 
	 	As needed:
	 	1.	 	Dust and spot clean walls and doors.	 
	 	 	 	 	 	 	 
	E.	ENTRANCE AREAS AND LOBBIES
	 	 	 	 	 
	 	Daily:
	 	1.	 	Vacuum carpet floors.	 
	 	 	 	2.	 	Collect trash.	 
	 	 	 	3.	 	Empty all ashtrays, damp wipe clean.	 
	 	 	 	4.	 	Clean sand urns, replenish sand as needed.	 
	 	 	 	5.	 	Clean any furniture and/or accessory equipment.	 
	 	 	 	6.	 	Spot clean walls and doors.	 
	 	 	 	7.	 	Sweep exterior entries.	 
	 	 	 	8.	 	Dry sweep tile and concrete floors.	 
	 	 	 	9.	 	Clean glass entrance doors.	 
	 	 	 	10.	 	Spot mop tile and concrete floors.	 

 

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	 	Weekly:
	 	1.	 	Spray/buff floors	 
	 	 	 	2.	 	Clean metal trim on entrance doors.	 
	 	Quarterly:
	 	1.	 	Machine scrub and wax tile floors.	 
	 	Semi-Annually:
	 	1.	 	Shampoo carpets.	 
	 	 	 	 	 	 	 
	F.	OFFICE AREAS
	 	 	 	 	 
	 	Daily:
	 	1.	 	Collect all trash.	 
	 	 	 	2.	 	Empty all ashtrays, damp wipe clean	 
	 	 	 	3.	 	Spot mop floors	 
	 	Mon., Wed. and Fri.:
	 	1.	 	Dry mop concrete and tile floors: dust mops to be
 treated with compound.	 
	 	 	 	2.	 	Vacuum carpets and clean spots as necessary.	 
	 	 	 	3.	 	Dust all furniture desks, phones, file cabinets, etc. within hand reach.	 
	 	Weekly:
	 	1.	 	Pick up recycle paper.	 
	 	Monthly:
	 	1.	 	Spray/buff tile floors.	 
	 	 	 	2.	 	Vacuum upholstered furniture.	 
	 	Quarterly:
	 	1.	 	Machine scrub and wax tile floors	 
	 	Annually:
	 	1.	 	Clean window blinds.	 
	 	As Needed:
	 	1.	 	Wash blackboards, if erased or requested.	 
	 	 	 	2.	 	Spot clean doors, walls and glass partitions.	 
	 	 	 	 	 	 	 
	G.	SHOP AND LABORATORY
	 	 	 	 	 
	 	Daily:
	 	1.	 	Collect all trash.	 
	 	 	 	2.	 	Spot mop concrete and tile floors.	 
	 	 	 	3.	 	Dry mop or sweep floors: dust mops to be treated with compound.	 
	 	Mon., Wed. and Fri.:
	 	1.	 	Dust desks, phones and file cabinets only.	 
	 	Weekly:
	 	1.	 	Damp mop concrete and tile floor areas.	 
	 	 	 	2.	 	Pick up recycle paper.	 
	 	Quarterly:
	 	1.	 	Machine scrub and wax tile floors.	 
	 	As Needed:
	 	1.	 	Spot clean doors, walls and glass partitions.	 

 

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	H.
	RESTROOMS AND LOUNGE AREAS
	 	 	 	 	 
	 	Daily:
	 	1.	 	Collect all trash.

	 
	 	
	 	2	 	Damp mop floor
    using sanitizer in water.	 
	 	 
	 	3.	 	Clean all bowls, basins, seats, urinals and receptacles using sanitizer in water.	 
	 	 
	 	4.	 	Polish fixtures, dispensers and mirrors.	 
	 	 
	 	5.	 	Check all dispensers and replenish supplies as required.	 
	 	 
	 	6.	 	Dust furniture	 
	 	As Needed:
	 	1.	 	Spot clean doors, walls and partitions.	 
	 	 
	 	2.	 	Damp dust all vinyl or other plastic covered furniture.	 
	 	 
	 	 	 	 	 
	I. 	DINING AREA, KITCHEN AREA AND SERVING
    AREA	 	 	 	 	 
	 	Daily:
	 	1.	 	Collect all trash.	 
	 	 
	 	2.	 	Vacuum carpet and spot clean when necessary.	 
	 	 
	 	3.	 	Sweep and spot mop concrete and tile floors.	 
	 	Weekly:
	 	1.	 	Damp mop concrete and tile floors.	 
	 	Monthly:
	 	1.	 	Spray/buff Serving Area ceramic tile floors.	 
	 	Quarterly
	 	1.	 	Machine scrub and wax Serving Area tile floors.	 
	 	Semi-Annually:
	 	1.	 	Machine scrub and wax Kitchen tile floors.	 
	 	Annually:
	 	1	 	Shampoo carpets.	 
	 	As Needed:
	 	1	 	Dust and spot clean walls, doors and partition	 
	 	 	 	 	 	 	 
	J.	CONFERENCE ROOMS AND AUDITORIUM	 	 	 	 	 
	 	
      Daily:

    
	 	1.	 	Wash blackboards, if erased.	 
	 	 	 	2.	 	Vacuum carpets.	 
	 	 	 	3.	 	Spot clean walls and doors.	 
	 	 	 	4.	 	Mop concrete and tile floors.	 
	 	 	 	 	 	 	 
	K.	RESTROOMS	 	 	 	 	 
	 	
      Daily:

    
	 	1.	 	Check rest rooms.	 
	 	 	 	 	 	 	 
	L.	ENTRANCE AND STAIRWAYS	 	 	 	 	 
	 	
      Daily

    
	 	1.	 	Check inside and outside entrances and stairs.	 
	 	 	 	2	 	Wash glass entrance doors.	 

 

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	M.	SITE	 	 	 	 	 
	 	Weekly:
	 	1.	 	Empty outside trash receptacles.	 
	 	 	 	2.	 	Stage recycle material for pick-up.	 
	 	As Needed
	 	1.	 	Change light bulbs.	 
	 	 	 	2.	 	Pick up and dispose of discarded material

(e.g., boxes, pallets).	 
	 	 	 	3.	 	Clean up water leaks and spills.	 
	 	 	 	4.	 	Clean picnic areas including ball field.	 

 

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SCHEDULE E

FURNTIURE, EQUIPMENT AND IMPROVEMENTS

[FOLLOWS THIS PAGE]

 

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SCHEDULE F

FORM OF LETTER OF CREDIT

[ISSUING BANK]

[Date]            

Eastview Holdings LLC

c/o LCOR Asset Management L.P.

One Penn Plaza, Suite 3310

New York, New York 10119

Ref: Irrevocable Letter of Credit
    No. _______________                       

Gentlemen:

By order of our client, [name of
    Tenant], [address of Tenant], we hereby open in your favor our clean irrevocable
    Letter of Credit No. ______________  for
    the aggregate sum of [amount of Security Deposit] United States Dollars,
    (U.S. $____________)
    effective  immediately and expiring at our [address of Bank] New York Office
    on  ___________ or
    any automatically extended date.

Funds under this Credit are available
    to you against presentation of your sight draft(s) drawn on us marked “drawn
  under Irrevocable Letter of Credit No. ____________ date [date of Letter of
    Credit]”,
  and accompanied by the following:

Beneficiary’s signed statement that [name of Tenant] has failed to comply with the terms and conditions of a contract described as Agreement of Lease between Eastview Holdings LLC, Landlord, and [name of Tenant], Tenant, dated [date of Lease].

It is a condition of this Letter of Credit that it shall be deemed automatically extended without amendment for one year from the present or any future expiration date hereof, unless thirty (30) days prior to any such date we shall notify you by registered mail that we elect not to
 consider this Letter of Credit renewed for any such additional period. Upon receipt by you of such notice, you may draw hereunder by means of your draft on us at sight, accompanied by the original Letter of Credit.

This Letter of Credit is transferable in whole but not in part by the beneficiary upon notice to the undersigned, without charge. Requests for transfer will be in the form of Annex A attached hereto, duly completed by an officer of your company and accompanied by the original
 of this Letter of Credit.

If we receive your sight draft as mentioned above, in accordance with the terms and conditions of this credit, here at our [address], New York Office we will promptly honor the same.

This Letter of Credit is subject to the Uniform Customs and Practice for Documentary Credits (1993 Revision) International Chamber of Commerce Brochure No. 500, shall be deemed

 

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to be a contract made under, and as to matters not governed by the UCP, shall be governed by and construed in accordance with the laws of the State of New York and applicable U.S. Federal Law.

	 	 	 	[Name of Bank]	 
	    
	 	 	 	 
	 	 	 	By: __________________________	 
	 	 	 	        Authorized Signature	 
	 	 	 	        Title:	 

 

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[ANNEX A TO BE ADDED BY ISSUING BANK, IF REQUIRED]

 

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SCHEDULE G

HVAC MODEL

Monthly HVAC (Heating, Ventilation and Air Conditioning) billings for each tenant are calculated by multiplying the monthly airflow in million cubic feet (MCF) for each tenant by the cost per MCF, also calculated monthly.

The monthly air flow for each tenant is determined by multiplying the full-load airflow rating of each fan feeding the tenant space in cubic feet per minute (CFM) by the runtime factor provided on the fan schedule and by 60 to provide an hourly usage in cubic feet. This is done
 each hour, and summed for the month to provide a total airflow for the month, expressed in MCF.

The runtime factor for each fan is provided on a fan schedule, and accounts for both partial runtime during an hour, and reduced flow on setback. Any changes to the fan schedule for billing purposes must be requested by the tenant in writing at least five (5) working days
 before the change is to take place.

Airflow from a fan providing air to more than one tenant will be allocated based on the percentage of MCF delivered.

The cost per MCF is determined by taking the appropriate costs associated with supplying and delivering conditioned air to tenant space and dividing it by the total airflow provided to the site, calculated as above and summing across all fans. This cost is calculated monthly.

 

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SCHEDULE H

PARKING AREA

[FOLLOWS THIS PAGE]

 

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SCHEDULE I

FIXED RENT

	FIXED RENT
	    
	 	 	 
	Premises
	Commencement Date to and including

August 31, 2007	September 1, 2007 to

and including the

Fixed Expiration Date	Renewal Terms
	    
	 	 	 
	Space A Premises
	$454,381 per annum

($37,865.08 per month)	$528,350 per annum

($44,029.17 per month)	Fair market rental value as determined
 in Article 43
	    
	 	 	 
	Space B Premises
	$58,501.50 per annum

($4,875.13 per month)	$68,025.00 per annum

($5,668.75 per month)	Fair market rental value as determined
 in Article 43
	    
	 	 	 
	Space C Premises
	$169,592 per annum

($14,132.67 per month)	$197,200 per annum

($16,433.34 per month)	Fair market rental value as determined
 in Article 43
	    
	 	 	 
	Space D Premises
	$44,204 per annum

($3,683.67 per month)	$51,400 per annum

($4,283.34 per month)	Fair market rental value as determined
 in Article 43
	Furniture Payment
	$158,505 per annum ($13,208.75 per
 month) 	$105,670 per annum ($8,805.84 per
 month) 	$63,402 per annum ($5,283.50 per
 month) from January 1, 2010 to and
 including the August 31, 2012. $0 after
 August 31, 2012

The Fixed Rent is the aggregate of the Fixed Rent for each of the spaces that comprise the Premises plus the Furniture Payment.

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