Document:

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                                                                    Exhibit 10.7

                           UNPROTECTED LEASE AGREEMENT

        THAT WAS DRAWN UP AND EXECUTED IN TEL AVIV ON SEPTEMBER 26, 2004

                                     BETWEEN

           "EMED" REAL ESTATE DEVELOPMENT AND INVESTMENTS COMPANY LTD.
                         Public Company No. 52-002359-9
                        Of 3 Hayetzira Street, Ramat Gan
                                                   (hereinafter: the "LANDLORD")
                                                                 ON THE ONE HAND

                                       AND

                           PREDIX PHARMACEUTICALS LTD.
                             COMPANY NO. 51-2864307
                        OF 3 HAYETZIRA STREET, RAMAT GAN
                                                     (hereinafter: the "TENANT")
                                                               ON THE OTHER HAND

In this Lease the following terms shall have the meanings set forth next to
them:

"THE STRUCTURE" OR "THE BUILDING"       - a building intended for offices for
                                        commerce and for parking on Bezalel
                                        Street, corner Hayetzira Street, in
                                        Ramat Gan, which is also known by the
                                        nickname "Sh. A. P. House".

"THE DEMISED PREMISES" OR "THE UNIT"    - 19th floor, north east.

"INDEX"                                 - The Consumer Price Index (including
                                        fruits and vegetables) that is published
                                        by the Central Statistics Office (the
                                        "OFFICE").

"THE BASIC INDEX"                       - The Index that was published on
                                        September 15, 2004 for the month of
                                        August 2004.

"LINKED" "LINKAGE DIFFERENTIAL"         Multiplying the relevant amount by the
"LINKED VALUES" AND ANY SIMILAR TERM:   relevant value between the last Index
                                        published before the time of the
                                        calculation and/or the payment relevant
                                        to the matter (hereinafter: the "NEW
                                        INDEX") and the Basic Index, or in the
                                        ratio between any other indices if it is
                                        so stated specifically in this Lease.

"THE REPRESENTATIVE RATE"               The representative rate of the Dollar as
                                        it is published by the Bank of Israel
                                        for the date

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                                        relevant for the carrying out of the
                                        calculation and/or the payment.

"THE DEMISED PREMISES FOR PURPOSES      600 square meters. This area is agreed
OF THE PAYMENT OF RENT"                 upon and is not given to inspection
                                        and/or taking exception and/or appeal on
                                        the part of any of the parties.

WHEREAS-                                the Landlord is the sole possessor of
                                        the Demised Premises and the owner of
                                        the rights to register as the sole owner
                                        of the Demised Premises, and it
                                        represents that it is entitled to lease
                                        the Demised Premises, and there is no
                                        impediment to entering into a
                                        contractual relationship by means of
                                        this Lease; and

WHEREAS -                               the Tenant approached the Landlord and
                                        proposed to it that it lease the Demised
                                        Premises from it, all pursuant to the
                                        terms and for the consideration detailed
                                        below in this Lease; and

WHEREAS -                               the Landlord agreed to lease the Demised
                                        Premises to the Tenant, all pursuant to
                                        the terms and for the consideration
                                        detailed below in this Lease and in the
                                        exhibits annexed to it; and

WHEREAS -                               the parties desire to define and arrange
                                        their legal relationship as detailed in
                                        this Lease Agreement as follows:

              THEREFORE, IT IS REPRESENTED, AGREED AND CONDITIONED
                         BETWEEN THE PARTIES AS FOLLOWS:

The Preamble to this Lease and the exhibits thereto constitute an integral part
thereof. In the event that any exhibit is not annexed to this Lease at the time
of its signing, that exhibit shall be annexed at the time of its preparation,
and it shall be deemed to be an integral part of the Lease.

1.    THE TRANSACTION

      The Landlord obligates itself to lease to the Tenant, and the Tenant
      obligates itself to lease from the Landlord, the Demised Premises pursuant
      to the terms and at the price detailed in the Lease, including its
      exhibits.

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2.    THE TENANT'S REPRESENTATIONS

      The Tenant represents that it inspected the Building and its surroundings,
      as well as the Demised Premises, and found them appropriate for its needs
      and that, subject to the delivery of the Demised Premises to the Tenant at
      the appointed delivery time in its current condition, the Tenant shall not
      have any claim of inappropriateness of any nature whatsoever, subject only
      to the terms of this Lease.

3.    THE PURPOSE OF THE LEASE

      3.1   The Tenant is leasing the Demised Premises in order to operate /
            manage offices therein (hereinafter: the "LEASE PURPOSE"), and for
            no other purpose.

      3.2   Any substantive change or broadening of the Lease Purpose requires
            the prior written approval of the Landlord.

      3.3   The Tenant represents and warrants that it will not object to the
            fact that the other businesses and offices or some of them will
            conduct their businesses at the times and the hours that they deem
            fit and that it will not have any complaint whatsoever with regard
            thereto.

      3.4   The Tenant represents and warrants that it is aware that other
            businesses and offices will operate in the Building, and it
            represents and warrants that it will not have any complaint
            whatsoever against the Landlord with regard thereto, including with
            regard to their hours of operation, the entry and exit arrangements
            they have, the noise interference, the oppression of smells, or any
            other nuisance whatsoever resulting from their activities.

      3.5   In order to avoid doubt, it is agreed and clarified hereby that the
            Tenant itself shall be responsible for obtaining all permits
            required by law to open and operate its business in the Demised
            Premises.

            The Tenant commits to fulfill all the terms required for the purpose
            of obtaining all the permits, as aforesaid, to manage its business
            pursuant to their terms, and to maintain them in effect throughout
            the entire lease term.

4.    THE TERM OF THE LEASE

      4.1   The lease term pursuant to this Lease shall commence on October 15,
            2004 (hereinafter: the "DELIVERY DATE"). The entry upon the Demised
            Premises shall be permitted already on October 3, 2004, and from
            that date onward the Tenant shall bear the costs of Arnona
            [municipal real estate taxes], electricity, water, maintenance, and
            the like, other than rental payments.

      4.2   The rental term shall terminate at the end of 24 months from its
            commencement, as stated in Section 4.1 above, that is, on October
            14, 2006 (the period between October 15, 2004 and October 14, 2006
            shall be referred to below as: the "LEASE TERM").

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            The Landlord hereby gives the Tenant its consent to extend this
            Lease after the Lease Term, for four (4) additional option terms of
            one year each, according to the absolute discretion of the Tenant.
            During the first option period, should the Tenant elect to exercise
            it, the same terms as are detailed in this Lease shall apply.
            Thereafter, should the Tenant elect to make use of the second option
            period, the rental payments (as defined in Section 5.1) shall be
            increased by 5% (the "MONTHLY RENTAL PAYMENTS"). The Monthly Rental
            Payments shall be in effect for the second option period and for the
            two periods thereafter, should the Tenant elect to exercise them,
            and the balance of the terms detailed in this Lease shall apply.

            Despite what is stated above, the Tenant shall be entitled at any
            time to bring a replacement tenant in its stead, who shall assume
            all the obligations pursuant to this Lease, provided that the
            Landlord approves the replacement tenant, as aforesaid. The Landlord
            shall be allowed to object to the replacement tenant only for
            reasonable reasons.

      4.3   INTERNAL WORK / IMPROVEMENTS / INSTALLATION OF AIR CONDITIONER

            4.3.1 The entry of the Tenant onto the Demised Premises shall be
                  conditioned on the delivery of the securities as detailed in
                  Section 14 below.

            4.3.2 The Landlord hereby gives its consent for internal work within
                  the Demised Premises, including improvements for the purpose
                  of making it compatible to the needs of the Tenant. This
                  consent is conditioned upon the delivery of a drawing of the
                  improvements which shall be approved by the Landlord.

            4.3.3 The Tenant shall solely be liable for the carrying out of the
                  internal work and it covenants that the works will be carried
                  out according to all laws related to their undertaking,
                  including safety instructions, and in coordination with the
                  management company.

            4.3.4 The Tenant shall be responsible for any damage that shall be
                  caused during the course of the internal work or as a result
                  thereof to those carrying out the work, to the Landlord and
                  its employees if they entered upon the Demised Premises in
                  coordination with the Tenant, to third parties, as well as to
                  the Demised Premises, to adjacent units, and to the project.

            4.3.5 The Landlord hereby gives its consent to the Tenant to install
                  two mini central air conditioners having a volume of six horse
                  power each, on the service floor of Sh. A. P. House, which
                  will serve to cool the service room in the Demised Premises
                  Building.

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5.    RENTAL PAYMENTS

      The Tenant shall pay the Landlord rent throughout each Lease Term, as
      detailed in the provisions of Section 4 above, in accordance with the
      provisions below:

      5.1   The Tenant shall pay the Landlord rent for the Demised Premises in
            the New Israeli Shekel equivalent of $14.50 (fourteen and one half
            U. S. Dollars) per square meter per month, in addition to Value
            Added Tax.

      5.2   The rent for the Demised Premises and throughout all the Lease Terms
            shall be paid by the Tenant each six (6) months in advance
            (hereinafter: the "RENT").

      5.3   Value Added Tax on the Rent, or any tax that comes in its stead, or
            any tax which, according to the law that imposes it, applies it to
            the Tenant, at the rate that shall apply from time to time according
            to the law, shall be the obligation of the Tenant and shall be paid
            by it by post-dated check dated the date of the payment of the VAT
            to the tax authorities with each payment on account of the rent in
            return for a tax receipt as provided by law. Any tax and/or impost
            which, according to the law that imposes it, applies it to the
            Landlord and/or on the owner of the Demised Premises, shall be paid
            by the Landlord and shall not influence the level of the Rent and
            its manner of payment.

      5.4   The Tenant covenants to pay the Rent to the Landlord and the
            management fees to the management company during the entire Lease
            Term, without any condition, and subject to the other terms of this
            Lease, including the provisions of the latter part of Section 4.2,
            whether it made use of the Demised Premises or not, for whatever
            reason. It is emphasized that any claim that the Tenant may have
            against the management company, including regarding setting off
            management fees, shall apply as well to the obligation that appears
            in this section regarding the management fees.

6.    ADDITIONAL PAYMENTS

      6.1   Throughout the entire Lease Term the Tenant shall pay, in addition
            to the Rent, all the municipal and/or governmental or other
            payments, imposts, arnonas, taxes and obligatory payments of any
            sort whatsoever, including fees, registration and license fees of
            any sort whatsoever relating to the Demised Premises and/or its
            operation and/or its maintenance which apply to whoever rents the
            Demised Premises. Taxes and imposts relating to the Demised
            Premises, its operation, its maintenance, or with regard to the Rent
            that will be imposed in the future and that are not in existence at
            the time of the execution of this Lease Agreement, shall be imposed
            upon the Tenant if it is determined therein that they apply to the
            Tenant. It should be emphasized that all that is stated above shall
            apply only and exclusively regarding payments relating to the use of
            the Demised Premises by the Tenant.

            The Landlord shall bear the payment of the property tax and other
            taxes if they are imposed in the future for the rights of ownership
            of the Demised Premises, as

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            well as income taxes for the Rent. The Landlord shall bear any tax
            and/or impost and/or other payment in which it is provided that it
            applies to the owner of the Demised Premises or on the party leasing
            out the property, including one-time imposts and fees, such as road
            imposts, sewage (that is not included as a regular monthly payment
            in the arnona payment), etc.

      6.2   Without derogating from the generality of the foregoing, the Tenant
            shall bear throughout the Lease Term all payments for the supply of
            water, electricity, telephone, arnona, business tax, sign tax, or
            any other expenditure relating to the use and operation of the
            Demised Premises. The Landlord represents that on those items there
            are no existing debts that were generated prior to the Lease Term
            and that are likely to prevent the use thereof by the Tenant.

      6.3   The Tenant shall bear, throughout the entire Lease Term, payments
            due for maintenance and management of the Building in accordance
            with the provisions of the Management Agreement to which it is a
            party and in accordance with the law.

      6.4   The Tenant covenants to notify in writing the City of Ramat Gan, the
            Electric Company, and other interested parties regarding the lease
            of the Demised Premises.

            Shortly after the time of the commencement of the lease the Tenant
            covenants, should the Landlord so direct him, to transfer the water
            and/or telephone and/or electricity and/or municipal and/or any
            other account that relates to a payment and/or tax that is the
            responsibility of the Demised Premises and generally is paid by the
            Tenant, to the name of the Tenant.

7.    MANAGEMENT OF THE BUILDING

      7.1   The Tenant will sign with the management company of the Building the
            Management Contract annexed hereto as Exhibit A. the Tenant shall
            pay the management company the management fees as demanded by the
            management company, in accordance with the Management Contract with
            it and in accordance with law.

      7.2   The signature of the Tenant on this Lease Agreement and on the
            Management Contract as an exhibit thereto constitutes a direct
            obligation toward the management company, as well as an obligation
            of the Tenant toward the Landlord to fulfill all of its obligations
            toward the management company, whether they are detailed in this
            Lease and whether as they are detailed in the Management Contract
            described above, subject to what is stated in Section 5.4 above.

8.    GARAGE AND PARKING SPACES

      Within the framework of the Building there were built an underground
      parking garage and an above ground parking garage (collectively: the
      "GARAGES"). The Tenant affirms that it is aware that the Garages are
      operated as garages for commercial purposes by an

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      external operator (hereinafter: the "OPERATOR"). It is agreed that the
      Landlord and the external Operator shall be entitled to determine, inter
      alia, a different price for a specific parking space than for an
      unreserved parking space, to collect parking fees from various users on
      the basis of parking by the hour, by the day, or any other period and
      similar commercial considerations upon which the Landlord and the Operator
      shall decide in their discretion.

9.    LIABILITY, INDEMNIFICATION AND INSURANCE

      The Tenant, and it alone, shall be liable for all bodily and/or property
      damages that shall be caused, as well as for any tort that shall occur in
      the Demised Premises - all in connection with the possession of the
      Demised Premises and/or the use that shall be made thereof, all on
      condition that the damage was not caused willfully and/or intentionally by
      the Landlord and/or the management company and/or by someone acting on
      their behalf or as a result of their failure to act.

      The Tenant absolves the Landlord from any liability for damage to property
      found on the Demised Premises (its own property or that of others), as
      well as for all indirect or consequential damages (loss of profits, loss
      of goodwill, etc.) should any of these occur during the Lease Term -
      regardless of what was the cause that brought them on, and all on
      condition that the damage was not caused by a willful or intentional act
      by the Landlord and/or the management company and/or by someone acting on
      their behalf or as a result of their failure to act.

      The Landlord shall not bear any liability for bodily injury to the Tenant
      itself, to the employees of the Tenant, to its customers, visitors,
      invitees, or to any other person who arrived at the Building at the
      direction of the Tenant or for any purpose whatsoever connected with the
      Tenant, to the business and/or in the Demised Premises, and which shall be
      caused in the Demised Premises, during the Lease Term, except in those
      cases where the Landlord willfully and/or intentionally caused the damage.
      The liability of the Tenant to the Landlord and/or anyone acting on its
      behalf who is located on the Demised Premises shall not apply if their
      presence is unlawful.

      It should be emphasized that the liability of the Tenant pursuant to this
      section is solely and exclusively with regard to the net area of the
      Demised Premises, and shall not apply to the public areas included within
      the framework of this Lease (including bathrooms, stairs, elevators,
      Garage, lobby and the like), and in any event are not intended to derogate
      from the Landlord's liability under law.

      The Tenant shall indemnify the Landlord for any damage and/or claim and/or
      debt that the Landlord shall be required to pay in connection with damages
      the source of which is an act of negligence on the part of the Tenant that
      shall have occurred in the Demised Premises and/or in connection with
      and/or related to the possession of the Demised Premises and/or in
      connection with the use made thereof and for which the Tenant is liable
      therefore, as noted above, all immediately upon receipt of the first
      demand in writing from the Landlord, and on condition that a notice of
      damage and/or claim and/or

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      debt as aforesaid is delivered to the Tenant immediately upon its receipt,
      and that the Tenant shall have the opportunity to defend against the same.

      Without derogating from the provisions of this Section 9, the provisions
      of the liability insurance and the indemnification are included in EXHIBIT
      C annexed hereto, and which constitute an integral part of this Lease.

10.   MAINTENANCE OF THE DEMISED PREMISES AND ITS MANAGEMENT

      10.1  The Tenant shall be responsible for obtaining the required licenses
            pursuant to any law for the use of the Demised Premises according to
            its purpose and to maintain them in force. The Landlord represents
            that all the licenses and permits in order to occupy the Demised
            Premises and to make general use thereof were received and lawfully
            are in effect.

      10.2  The Tenant shall conduct its business in accordance with all laws
            relating thereto, and without causing any interference including,
            but not limited to, noise, smell, pollution, etc., and also not to
            interfere with the other businesses and offices and the environment,
            and also not to interfere with their quiet enjoyment, except for
            reasonable activities, such as repairs, moving equipment, and the
            like.

      10.3  The Tenant shall conduct its business in the Demised Premises while
            paying close attention to the regulations and the instruction of the
            management company as a result of its authority, as set forth in
            Section 7 above and its subsections.

      10.4  Subject to the liability of the Landlord as the developer who
            established the Building to repair defects that are discovered in
            the Demised Premises and that flow from defective construction, use
            of defective materials, and the like, the Tenant covenants to
            maintain the Demised Premises during the entire Lease Term in a good
            and orderly condition, and will repair without delay and at its own
            expense, any spoilage, damage or defect that is revealed therein
            that is a result of its use, except reasonable wear and tear. Should
            the Tenant not have done so within a reasonable amount of time from
            when it was requested to do so, then the Landlord shall be entitled
            to enter upon the Demised Premises to do so in its stead and at its
            expense, and that without derogating from the right of the Landlord
            for any other relief.

            The Tenant will relinquish the possession of the Demised Premises to
            the Landlord at the end of the Lease Term or sooner if this Lease is
            terminated, in the same condition in which it received it, subject
            to reasonable wear and tear. Prior to the vacation of the Demised
            Premises, the Tenant shall remove from the Demised Premises at its
            own expense each object and each addition or fixed device that was
            installed by it and shall restore the situation to its prior
            condition unless the Landlord expressly and in writing agreed to
            leave some of them in the Demised Premises, in which case the same
            shall become its property without any payment therefor. The
            provisions of this section shall not apply to the results of the
            improvements that will be carried out by the Tenant, as stated in
            Section 4.3

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            above, and which shall be acceptable to the Landlord after approval
            of the drawing of the improvement by the Landlord, as stated above.

      10.5  The Landlord shall be entitled, should it so desire, to enter the
            Demised Premises from time to time at reasonable times and with
            prior coordination in order to inspect the fulfillment of the terms
            of this Lease Agreement and/or in order to carry out works and
            repairs.

      10.6  The Tenant shall not be entitled to make changes and/or additions to
            the Demised Premises without the prior written consent of the
            Landlord, and in accordance with the terms of the consent, if it is
            given, all according to the absolute discretion of the Landlord,
            provided that the consent not be withheld other than for reasonable
            and relevant grounds.

      10.7  The Tenant shall not affix signs or notices on the external walls of
            the Demised Premises or the Building without the prior written
            consent of the payment of the sign tax according to the law. It is
            agreed that the Tenant is entitled to affix and/or to install signs
            on the entrance door to the office, in the lobby of the floor, and
            in the lobby at the entrance to the Building -- at a place set aside
            for it on behalf of the Building management.

      10.8  The Tenant will not permit the activities of outside contractors in
            the Demised Premises or in the surroundings without the written
            consent of the Landlord, and in any case the Tenant shall be
            required to verify that the contractor will operate in coordination
            with the Landlord and/or the management company and/or their
            representatives and will follow all the directives given by them.
            The aforesaid shall not apply to repairs or minor works that are not
            likely to affect the Demised Premises and its devices.

      10.9  If, and to the extent that, within the framework of the Demised
            Premises a shelter is included, the Tenant shall have the right to
            use the protected area, subject to the Tenant's obligation to permit
            all the tenants of the floor and/or the Building to use the
            protected area where the same is required, in accordance with the
            directions of the civil defense forces and any other appropriate
            authority.

            The Tenant obligates itself not to make use of the protected area,
            not to install therein devices, and not to make changes and/or
            additions to it other than as permitted or required pursuant to the
            instructions of the appropriate authorities as they shall be
            installed and/or be amended from time to time.

            Should the Tenant not act in accordance with the directives of the
            civil defense authorities and/or any other appropriate authority,
            then the Landlord shall be entitled to enter upon the protected area
            and act therein on its own in accordance with the directives of the
            appropriate authorities, but only after it requested that the Tenant
            do so and it did not do so within a reasonable period of time from
            the time that it was requested so to do.

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11.   ASSIGNMENT OF RIGHTS

      11.1  The Tenant shall not lease the Demised Premises or any part thereof
            in a sublease, shall not assign it or any part thereof to another
            and shall not permit anyone else to make use of it or any part
            thereof, for or without consideration, and likewise it will not
            place a charge or mortgage on any of its rights under this Lease
            Agreement unless it received the express prior written consent of
            the Landlord.

      11.2  The Landlord shall be entitled to transfer and/or to assign and/or
            to charge, in part or in whole, its rights in the Building and/or to
            the Demised Premises and/or its rights pursuant to this Lease, in
            whole or in part, provided that the rights of the Tenant not be
            affected. The Tenant obligates itself to cooperate and to sign any
            document that is required or that it shall be requested by the
            Landlord to approve and/or to carry out the foregoing.

12.   RELIEF AND REMEDIES

      12.1  If any party to this Lease Agreement breaches one of its terms, the
            injured party shall be entitled to all the remedies provided in the
            Contracts Law (Remedies for Breach of Contract), 5731-1970, and that
            without derogating from the provisions of this Lease or the
            provisions of any law, and that also in case a specific relief is
            provided is determined for any breach within the framework of this
            Lease.

      12.2  Without derogating from its rights to greater compensation or to any
            other relief, it the case of a fundamental breach of this Lease
            Agreement by the Tenant, or any other breach which is not cured
            within 30 days of the written demand of the Landlord, then the
            Landlord shall be entitled to receive liquidated damages estimated
            in advance to be $3,000 per month (or the pro rata portion thereof)
            linked to the Index as specified, and until the actual date of
            payment, and that whether it opts to enforce the lease or opts to
            terminate it, and the parties represent that they view the above
            amount as fair compensation for the damage that the parties view as
            the aggregate outcome of the fundamental breach of this Lease
            Agreement.

      12.3  Any breach of any of the provisions of the Lease set forth below
            shall be deemed to be a fundamental breach thereof:

            12.3.1 Any breach of the provisions of Subsections 3.1, 7.1, 10.4,
                   10.6 and Sections 11 and 14 of this Lease that is not cured
                   within 14 days from the time of the giving of notice by the
                   Landlord.

            12.3.2 A delay in the making of any payment that the Tenant is
                   obligated to make pursuant to the provisions of Sections 5
                   and 6 (including the subsections thereof) of this Lease, for
                   a period in excess of 14 days and/or any 3 consecutive late
                   payments of a payment that the Tenant must make to the
                   Landlord during the course of a lease year.

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            12.3.3 Any other breach that is not cured within 30 days from the
                   time that the Landlord demanded that the Tenant cure the
                   aforesaid breach.

      12.4  The Landlord shall be entitled to cancel this Lease Agreement and to
            demand that the Tenant immediately vacate the Demised Premises and
            return the possession thereof to it under the terms provided in
            Section 10.4 above in each of the following cases:

            12.4.1 The Tenant made a fundamental breach of this Lease Agreement.

            12.4.2 The Tenant breached in any manner the provisions of this
                   Lease Agreement and did not cure the breach within 30 days
                   from the date requested.

            12.4.3 A motion was submitted to a court having jurisdiction to
                   liquidate the Tenant or to declare it bankrupt, to appoint a
                   trustee, liquidator, temporary liquidator, preliminary
                   liquidator, a receiver for a substantial portion of its
                   assets for it, and a court order is issued in response to the
                   motion, and the order is not set aside within 90 days of its
                   having been issued and/or id the Tenant filed a motion for
                   its liquidation or to have it declared a bankrupt and/or to
                   have an arrangement of creditors.

            If a cancellation notice is given, the following provisions shall
            apply:

            In the case the Tenant is liquidated, the Landlord shall have the
            right of a lien under law as security for the payment of all the
            damages and the funds that will be due to the Landlord and/or the
            management company from the Tenant in such a situation.

            12.4.4 The Tenant will be responsible for the return to the Landlord
                   immediately upon the receipt of a first written demand all
                   reasonable expenses, damages and reasonable losses that will
                   be caused to it as a result of the breach of the Lease by the
                   Tenant, and according to law.

            12.4.5 The Tenant shall not have the right to object by any means
                   and/or to attempt to delay or to prevent the Landlord from
                   entering into a contractual relationship with any other
                   tenant and/or to attempt to prevent or to delay the carrying
                   out the renting of the Demised Premises to any replacement
                   tenant whatsoever. All the foregoing shall apply both to the
                   relationship between the Landlord and the Tenant and between
                   the Tenant and the replacement tenant and shall be deemed to
                   be, inter alia, a contractual provision for the benefit of a
                   third party.

      12.5  Any delay in the making of a payment by any party shall bear default
            interest at the rate customary at Bank Hapoalim B.M. for
            extraordinary overdrafts at that time for the period of the delayed
            payment.

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      12.6  In any case in which the Tenant shall be late at his fault by more
            than 30 days in the transfer of any payment that it is obligated to
            make to the Landlord, then the Landlord shall be entitled, on thirty
            (30) days' written notice to the Tenant, and without derogating from
            its right to any other relief, to immediately cease to supply to the
            Tenant and/or the Demised Premises electricity, water, air
            conditioning or other services whatsoever, at its discretion, and
            the Tenant shall not have any contention or claim with regard
            thereto.

      12.7  In any case of failure to vacate the Demised Premises on time by the
            Tenant at the end of the Lease Term or upon the cancellation of this
            Lease Agreement, then the Landlord shall be entitled, without
            derogating from its rights for any other relief, and after having
            given sixty (60) days' written notice thereof:

            12.7.1 to immediately cease to supply to the Tenant and/or the
                   Demised Premises electricity, water, air conditioning or
                   other services whatsoever, at its discretion, and the Tenant
                   shall not have any contention or claim with regard thereto.

            12.7.2 to enter the Demised Premises itself and/or by means of
                   others, and in order to do so to use reasonable force, and to
                   remove all possessions and tangible items that are found
                   there from the Demised Premises, as well as to the change the
                   locks and to prevent access to it by the Tenant or any one
                   acting on its behalf in any way it deems appropriate.

                   In any case of failure to vacate the Demised Premises on
                   time, as aforesaid, by the Tenant, the Tenant or the party
                   acting on its behalf shall be deemed to be a "squatter" upon
                   the Demised Premises, and it shall not have any contention or
                   claim against the Landlord or anyone acting on its behalf for
                   the damages caused to it or its possessions as a result of
                   such an activity.

                   The Tenant shall be liable to pay the Landlord for all the
                   expenses caused to the Landlord or to someone acting on its
                   behalf in the foregoing actions.

      12.8  The delay in, or failure to use any right on the part of the
            Landlord pursuant to this Lease Agreement shall not be deemed under
            any circumstances or in any case to be a "waiver" or the basis for a
            claim of forbearance against it on the part of the Tenant, subject
            to the law.

13.   ABSENCE OF PROTECTED TENANCY RIGHTS

      13.1  It is specifically represented that the Demised Premises is located
            in a building that was completed after August 20, 1968, and that
            this tenancy is being made expressly conditioned on the fact that
            the protected tenancy laws do not apply to the tenancy, the Tenant
            represents that it did not and will not pay the Landlord key money
            or any other consideration that is not rent, and that the Tenant and
            any party coming in its place will not be a protected tenant in the
            Demised Premises pursuant to the law, and that it will be prohibited
            from raising any contentions or

<PAGE>

            claims whatsoever with regard to its being a protected tenant or
            that it has greater rights in the Demised Premises than what is
            specifically stated in this Lease.

      13.2  The Tenant represents that all the investments that it shall make in
            the Demised Premises, including equipment and devices, shall be made
            solely for its needs, and it shall be prohibited from raising the
            contention that these investments constitute key money or a
            substitute for key money or a payment pursuant to Section 82 of the
            Protected Tenant's Law (Consolidated Version), 5732-1972, or any
            payment that grants it rights whatsoever in the Demised Premises,
            and likewise, it will be prohibited from demanding a contribution or
            a refund, in whole or in part, from the Landlord for the foresaid
            investments.

14.   SECURITY

      BANK GUARANTY

      14.1  As surety to the fulfillment of all the obligations pursuant to this
            Lease Agreement, the Tenant shall present to the Landlord prior to,
            and as a condition to, entering upon the Demised Premises for the
            purposes of carrying out the internal work as detailed in Section
            4.3 above, an assignable unconditional bank guaranty, made out to
            the benefit of the Landlord, exercisable in installments, stamped as
            required by law, at the expense of the Tenant, in the form annexed
            to this Lease as Exhibit B, to remain in force until 45 days after
            the end of the Lease Term, in the sum of $43,500 (forty three
            thousand five hundred U. S. Dollars).

      14.2  The Tenant shall bear all the costs of the bank guaranties,
            including the fees of the guarantor bank.

      14.3  The Landlord shall be entitled to exercise the guaranty (or a part
            thereof, as the case may be, and in accordance with the amount of
            the debt) in any case of a fundamental breach of this Lease
            Agreement by the Tenant or in any case in which any funds are due to
            the Landlord from the Tenant, which were not paid when due, provided
            that the Tenant was provided with 14 days' prior written notice
            before the drawing down of the guaranty.

      14.4  The foregoing notwithstanding, it is agreed that the Tenant may
            provide the Landlord with a bank guaranty for a shorter period of
            time on condition that the Tenant sees to it that the effectiveness
            of the guaranty is extended from time to time at least fourteen (14)
            days prior to its anticipated expiration date.

      14.5  If the Tenant does not present the Landlord with an alternative bank
            guaranty at the aforesaid time, then the Landlord shall be entitled
            to exercise the full bank guaranty in its possession, provided it
            notifies the Tenant thereof in writing 14 days prior to the drawing
            down of the guaranty.

<PAGE>

15.   ARBITRATION

      In any case in which disputes arise and/or differences between the parties
      with anything regarding the execution and/or the effectiveness or breach
      and/or the carrying out and/or the interpretation of this Lease, the
      parties will submit the disputes or the differences for the determination
      of an arbitrator whose identity shall be determined by the agreement of
      the parties, or in the absence thereof, the arbitrator shall be appointed
      within ten (10) days from the date on which no agreement between the
      parties was reached by the Chairman of the Israel Bar Association, at the
      request of one of the parties, after giving three days' prior written
      notice to the other party (hereinafter: the "ARBITRATOR").

      15.1  The Arbitrator shall act as the sole arbitrator and his
            determination shall be final.

      15.2  The provisions of this Section 15 shall be deemed to be an
            arbitration agreement between the parties, and the provisions of the
            Addendum to the Arbitration Law, 5728-1968, shall apply to the
            arbitration that is the subject of this Lease, as well as to the
            Arbitrator.

      15.3  It is agreed that the authority of the Arbitrator shall be
            specifically subject to the provisions of this Lease, including its
            exhibits, and that the Arbitrator shall be empowered to issue
            temporary orders and other temporary relief, and he shall be subject
            to the substantive law but not to the laws of evidence and
            procedures.

      15.4  A referral to the Arbitrator or the engaging in arbitral proceedings
            shall not give rise to the delay and/or postponement and/or
            exemption of the Tenant any of its obligations as set forth in this
            Lease, including its obligations to make any payments as long as the
            Lease Term is in effect.

      15.5  Anything contained in this Section 15 notwithstanding, the Landlord
            has the right to sue the Tenant in the appropriate court in Tel Aviv
            - Jaffa for the eviction or removal of the Tenant from the Demised
            Premises at the end of the Lease Term and/or upon the cancellation
            of this Lease, on condition that no approach has been made to
            appoint an Arbitrator.

16.   MISCELLANEOUS

      16.1  The Landlord shall be entitled at any time, without the need for any
            consent on the part of the Tenant, to make any change or addition to
            the Building that will not have a substantial detrimental affect on
            the Tenant, its work environment, or its approach thereto, according
            to its absolute discretion, both prior to and after the commencement
            of the Lease Term, including, but not limited to, the addition or
            diminution of area, to add floors, areas or wings to the Building,
            the conversion of closed or open public areas to areas in the
            exclusive use of various users, changes in the entrances, passage
            ways, extra area of any kind, and any other change in construction
            or in the Building plans.

            Likewise, the Tenant is aware that the Landlord intends to add
            construction area beyond what is currently permitted according to
            the zoning regulations and the

<PAGE>

            Tenant agrees to any additional construction that may be made,
            subject to the foregoing.

            The Landlord obligates itself that the aforesaid changes and
            additions, if they are undertaken, will be made subject to building
            permits if required, and that they will be made in a manner such
            that the interference to be caused to the Tenant shall be the
            minimum amount possible, in a reasonable manner, and that the
            completeness of the Demised Premises will not be affected.

      16.2  This Lease reflects the entirety of all the understandings between
            the parties and it replaces and voids any negotiations, heads of
            agreement, representation or document that preceded its execution,
            any change in the provisions of this Lease shall be effective and
            binding only if in writing and lawfully signed by both parties.

      16.3  The debts that the parties to this Lease owe to each other are
            subject to set off only upon prior written agreement.

      16.4  Any change and/or waiver and/or variance from the provisions of this
            Lease shall not be binding unless done in writing and signed by the
            parties to the Lease.

      16.5  The addresses of the parties for the purposes of giving notices
            shall be as set forth at the head of the Lease. Any notice that
            shall be sent by registered mail shall be deemed to be received by,
            and brought to the attention of, the recipient party within five
            days of its dispatch, and in the case of hand delivery, within 12
            hours of its delivery.

            IN WITNESS WHEREOF, THE PARTIES HAVE EXECUTED THIS LEASE:

          /s/ ILAN SCHEFFLER                      /s/ SILVIA NOIMAN
-------------------------------------     -------------------------------------
"EMED" REAL ESTATE DEVELOPMENT            PREDIX PHARMACEUTICALS LTD.
   AND INVESTMENTS COMPANY LTD.
           (the Landlord)                            (The Tenant)
By Mr. Ilan Scheffler, Vice President     By Dr. Silvia Noiman, General Manager

<PAGE>

                               INSURANCE ADDENDUM

                                    EXHIBIT C

        TO AN UNPROTECTED LEASE AGREEMENT THAT WAS DRAWN UP AND EXECUTED
                        IN TEL AVIV ON SEPTEMBER 26, 2004

BETWEEN:     "EMED" REAL ESTATE DEVELOPMENT AND INVESTMENTS COMPANY LTD.
             Public Company No. 52-002359-9
             3 Hayetzira Street
             ShAP House, Ramat Gan
             (hereinafter: the "LANDLORD")
                                                                 ON THE ONE HAND

AND BETWEEN: PREDIX PHARMACEUTICALS LTD.
             Company No. 51-2864307
             3 Hayetzira Street
             ShAP House, Ramat Gan
             (hereinafter: the "TENANT")
                                                               ON THE OTHER HAND

1.    Without derogating from the liability of the Tenant pursuant to this Lease
      or in accordance with any law, prior to the time of commencement of the
      business of the Tenant in the Demised Premises, or prior to the time of
      the bringing in of any property into the Demised Premises - the earlier of
      the two, the Tenant commits to arrange and keep for the duration of the
      term of this Lease the insurances detailed in the continuation of this
      section (which shall hereinafter be called: the "DEMISED PREMISES
      INSURANCES") with a lawfully authorized and reputable insurance company.

      1.1   Insurance of the contents of the Demised Premises, equipment that
            serves the Demised Premises owned and/or under the responsibility of
            the Tenant that is located outside the Demised Premises within the
            Building, as well as any repair, change, improvement, enhancement
            and addition to the Demised Premises that is made and/or will be
            made by the Tenant and/or for it, as well as furniture, equipment
            and devices of any kind or nature whatsoever, against loss or
            damage, as a result of fire, smoke, lightening, explosion,
            earthquake, storm, tempest, flood, damage from liquids and pipe
            breakages, the impact of an accident, the impact of an airborne
            device, strikes, disturbances, intentional damage and break-ins. The
            insurance shall include a specific condition in which the insured
            waives any right to subrogation against the Landlord and/or against
            the management company, as well as the other tenants and/or
            residents in the Building (as well as those employed by those
            mentioned above), whose insurance includes a comparable

<PAGE>

            provision regarding waiving the right of subrogation. This section
            shall not apply for the benefit of a person who intentionally caused
            damages.

      1.2   Third party liability insurance with a liability limit that shall
            not be less than an amount in New Israeli Shekels equal to $500,000
            (five hundred thousand U. S. Dollars) per event and in the aggregate
            per year of insurance. This insurance shall not be subject to any
            limit regarding liability resulting from fire, explosions, fright,
            lifting devices, unloading and loading, defective sanitary devices,
            poison, any damaging item in food or drink, liability toward or as a
            result of contractors, subcontractors and their employees (with
            regard to whom the insured is not entitled to indemnification
            pursuant to Section 1.3 below), strikes and lockouts, as well as
            substitution claims on the part of the National Insurance Institute.
            The insurance shall be expanded to indemnify the Landlord and/or the
            management company for their liability for the acts of commission or
            omission of the Tenant, and that, subject to the section of cross
            liability, according to which the insurance shall be deemed to have
            been separately entered into for each Unit of the insured.

      1.3   Employer's liability insurance for the Tenant's liability toward all
            those employed by it, with a limit of liability that shall not be
            less than that which is customary in Israel at the time of entering
            into the insurance and/or its renewal. This insurance shall not have
            any limitation with regard to work at heights or in depth, hours of
            work, liability toward contractors, subcontractors and their
            employees, traps and poisons, as well as regarding the employment of
            youth. The foregoing insurance shall be expanded to indemnify the
            Landlord and/or the management company in the event that they should
            be deemed to be employers of the Tenant's employees or any of them.

            Demised Premises Insurances shall include a specific provision
            according to which they take precedence over any insurance entered
            into by the Landlord and/or the management company and that the
            insurer waives any claim and/or demand regarding participation in
            the insurance of the Landlord or the management company. Likewise,
            the insurer commits that the policies will not be reduced or
            cancelled unless a written notice with regard thereto is sent by
            registered mail to the Landlord at least 60 days in advance.

      1.4   Insurance for the loss of income of the Tenant in its full value for
            damages covered pursuant to Sections 1.1 and 5.1 below, for an
            indemnification period that shall not be less than 12 months.

            Despite what is stated above, the Tenant is permitted not to obtain
            loss of income insurance; however, what is stated in Section 3 shall
            apply to the aforesaid loss of income as if insurance had been
            obtained.

2.    The Tenant covenants to update from time to time the amount of the
      insurance for the insurance obtained pursuant to Section 1.1 above in
      order to always reflect the full value of the property insured thereunder.

<PAGE>

3.    The Tenant represents that it will not have any contention and/or demand
      and/or claim against the Landlord and/or the management company and/or
      other tenants and/or other residents of the Structure who, in their lease
      agreements or in any other contract that grants them rights in the
      Structure, which includes a comparable exemption toward the Tenant for
      damages for which it is entitled to indemnification pursuant to the
      insurances that it committed to obtain according to Sections 1.1 and 1.4
      above, and it exempts hereby those mentioned above from any liability for
      damages, as aforesaid. What is stated above regarding the exemption from
      liability shall not apply for the benefit of a person who intentionally
      caused damages.

4.    The Tenant covenants to comply with the terms of the policies, to pay the
      insurance premiums in full and on time, and to see to it and to ensure
      that the insurance policies are renewed from time to time as required and
      that they shall remain in force throughout the Lease Term.

5.    The Landlord covenants, through the management company, to procure the
      following insurances from lawfully authorized and reputable insurance
      companies in Israel throughout the Lease Term:

      5.1   Building insurance from loss or damage as a result of damages
            resulting from the risk of fire, smoke, lightening, explosion,
            earthquake, storm and tempest, flood, damage from liquids and pipe
            breakages, the impact of an accident, the impact of an airborne
            device, disturbances, strikes, intentional damage and break-ins.

            The management company shall be entitled to expand the scope of the
            insurance coverage and to include in the insurance other risks as
            well as to which it is customary to obtain insurance.

            The foregoing insurance shall contain a provision regarding the
            waiver of the right of subrogation against the tenants and the
            residents and all those employed by them, provided that the
            foregoing with regard to the waiver of the right of subrogation
            shall not apply for the benefit of a person who intentionally caused
            damage. For the purpose of this section, the term "the Building"
            shall include all the systems that constitute an integral part of
            the Structure, and shall expressly not include the contents of
            demised premises and all additions, improvements or extensions that
            were made to the demised premises by or for the tenants.

            The policy shall be expanded to include coverage for the loss of
            rental payments and management fees for a period that shall not be
            less than 12 months, as a result of damage to the Structure that is
            covered by the policy.

            The foregoing regarding the exemption from liability shall not apply
            for the benefit of a person who intentionally caused damages.

      5.2   Third party liability insurance that insures the liability of the
            Landlord, the management company and the tenant from any injury or
            damage to the body and/or the property of any person and/or body
            whatsoever within the public areas of the Structure, with a
            liability limit that shall not be less than $3,000,000 (three

<PAGE>

            million U. S. Dollars) per event and in the aggregate per year of
            insurance. This insurance shall not be subject to any limit
            regarding liability resulting from fire, explosions, fright, lifting
            devices, unloading and loading, defective sanitary devices, poison,
            any damaging item in food or drink, liability toward or as a result
            of contractors, subcontractors and their employees (with regard to
            whom the insured is not entitled to indemnification pursuant to
            Section 1.6.3 below), strikes and lockouts, as well as substitution
            claims on the part of the National Insurance Institute. The
            insurance shall include a section of cross liability, according to
            which the insurance shall be deemed to have been separately entered
            into for each Unit of the insured.

      5.3   Employer's liability insurance that insures the liability of the
            Landlord and/or the management company against those employed by
            them for bodily injury or sickness during the course, or as a
            result, of their work, with a limit of liability that shall not be
            less than that which is customary in the insurance market at the
            time of entering into the insurance. This insurance shall not have
            any limitation with regard to liability toward contractors,
            subcontractors and their employees, traps and poisons, as well as
            regarding the employment of youth.

      5.4   The Landlord and the management company represent that they will not
            have any contention and/or demand and/or claim against the Tenant
            and those employed by it for damages for which they are entitled to
            indemnification pursuant to the insurances that they committed to
            obtain according to Section 5.1 above, and they exempt hereby those
            mentioned above from any liability for damages, as aforesaid. What
            is stated above regarding the exemption from liability shall not
            apply for the benefit of a person who intentionally caused damages.

            IN WITNESS WHEREOF, THE PARTIES HAVE EXECUTED THIS LEASE
                     AT THE PLACE AND THE TIME STATED ABOVE:

"EMED" REAL ESTATE DEVELOPMENT
  AND INVESTMENTS COMPANY LTD.

         /s/ ILAN SCHEFFLER                             /s/ SILVIA NOIMAN
-------------------------------------            ------------------------------
           the Landlord                                   The Tenant

<PAGE>

                              MANAGEMENT AGREEMENT

        that was drawn up and executed in Tel Aviv on September 29, 2004

                                     between

                  SH.A.P. HOUSE - EMAD MANAGEMENT COMPANY LTD.
                  Company No. 512674177
                  Whose address is Sh.A.P. House
                  On Bezalel Street corner Hayetzira Street, Ramat Gan
                  (hereinafter:  the "MANAGEMENT COMPANY")
                                                                 on the one hand

                                  and between:

                  PREDIX PHARMACEUTICALS LTD.
                  Company No. 51-2864307
                  Of 3 Hayetzira Street, Ramat Gan
                  Care of its directors, Messrs. _________
                  (hereinafter: the "POSSESSOR")
                                                               on the other hand

DEFINITIONS

Except if the contents of the writing compel otherwise, the following words
shall be given the meanings set forth next to them:

"THE LAND"

The field known as Temporary Field No. 2 that was created or that shall be
created by dint of the provisions of Zoning Plan R.G. 942 amendment to detailed
Zoning Plan RG/293/A RG/293/B and RG 792, RG/1/1097, RG/1097 and the Zoning
Regulations having a gross registered area of some 3,050 square meters, subject
to set asides for public purposes in accordance with the Zoning Plan.

"THE BUILDING"

A building intended for offices for commerce and for parking that was built on
the Land in accordance with and subject to the provisions of the Zoning Plan,
the building permit, the plans and technical specifications, and the rest of the
provisions of the Lease Contract, including its exhibits.

"UNIT"

A unit located on the __ floor above the floor intended for commercial use (the
__ floor above the ground level) as marked in yellow on the sketch annexed as
Exhibit A to the Lease Contract.

"THE UNIT AREA"

600 square meters. This area is agreed upon and is not given to inspection
and/or taking exception and/or appeal on the part of any of the parties.
<PAGE>

(OR THE AREA OF THE DEMISED PREMISES FOR PURPOSES ASSESSING THE RENT, AS THAT
TERM IS DEFINED IN THE LEASE AGREEMENT)

"SH.A.P."

Sh.A.P. Company Ltd.

"EMAD"

Emad Real Estate Development and Investments Company Ltd.

"THE LEASE CONTRACT"

The Lease pursuant to which the Possessor leased the Unit from Emad.

"THE COMMON AREAS"

The common property, as detailed in the Articles of Association of the
cooperative house, as well as the machines and the areas located in the
Building, or that serve them, or that are used or are intended to be used by all
or most of the users of the Building, even if they are not part of the common
property.

"MACHINERY"

The air conditioning machinery and systems, elevators, electricity, plumbing,
water, sewage, drainage, and the like, that are intended, or that the Management
Company shall intend them from time to time for common use by the possessors of
the Units and/or the users of the Building or by a majority of them, directly or
indirectly, and all, whether they are located in the area of the Building or if
not.

"THE SERVICES"

Management, operation, repair, maintenance, equipment renewal, funds for the
renewal and the replacement of equipment, cleaning, overhaul, repairs, lighting,
concierge, gardening, insurance of the Common Areas and of the Machinery, as
defined above, and of the Machinery and areas in the Building that serve and/or
are used by and/or are intended to be used by all or most of the users of the
Building.

Taking into consideration the special nature of the Building and its complexity,
and with the objective of a proper standard of the Building and its Services,
the Services may also include special services that are not customary in an
ordinary building, such as various types of security, the payment of taxes and
mandatory payments of all kinds that apply to the Common Areas, the operation
and supply of various services to the residents of the Building for their
pleasure and profit and the like, all at the discretion of the Management
Company, as detailed in Section 2.3 of this Agreement.

Other terms and concepts that appear in this Agreement and in the Lease
Agreement shall have the meaning in this Agreement that is ascribed to them in
the Lease Agreement unless it is expressly stated to the contrary in the terms
of this Agreement.

WHEREAS     the Possessor leased rights to a Unit in the Building from Emad; and

WHEREAS     the nature and standard of the Building require that the management
            and operation of the Services be concentrated in the hands of a
            single professional who will carry them out in an exclusive manner;
            and

<PAGE>

WHEREAS     the Management company to take it upon itself to fulfill this task;
            and

WHEREAS     the Possessor is or will be the owner of rights in the Unit which
            will buy him the right of possession in the Unit; and

WHEREAS     the Possessor is interested and agrees to it that the exclusive
            management and carrying out of the Services be in the hands of the
            Management Company, in accordance with, and subject to, the terms of
            this Agreement; and

WHEREAS     this Agreement constitutes the Management Agreement referred to in
            the Lease Agreement, as well as in the agreed upon Articles of
            Association of the Building, which will be recorded as the Articles
            of Association of a cooperative house; and

WHEREAS     in the Lease Agreement it was provided that close to the completion
            of the Building, its management, operation, maintenance and the
            rendering of Services in it will be handed over to the Management
            Company.

      THEREFORE, IT IS AGREED, REPRESENTED AND CONDITIONED BETWEEN THE PARTIES
      AS FOLLOWS:

1.    THE RULE OF THE PREAMBLE AND THE EXHIBITS

      The Preamble to this Agreement, including the definitions and the
      representations contained therein, as well as all the Exhibits thereto,
      constitute an integral part thereof.

2.    THE NATURE OF THE CONTRACTUAL RELATIONSHIP

      The Management Company accepts the exclusive management and the carrying
      out of the Services, and the Possessor agrees thereto, and hands over to
      the Management Company in an exclusive manner the management and the
      carrying out of the Services, under the conditions and the consideration
      detailed in this Agreement.

      The Possessor covenants not to undertake the Services or any part thereof
      on its own or by means of any other party other than the Management
      Company.

      2.1   The Management Company shall be entitled, from time to time, at its
            discretion, to determine the scope of the Services, their type,
            nature, and frequency, and which of them will be supplied to the
            Common Areas or to certain parts thereof, and the times and manner
            of their supply.

      2.2   The Possessor empowers the Management Company to take possession or
            to make use of the Common Areas and the Management Company covenants
            to do so.

      2.3   Subject to what is stated in Section 2.1 of this Contract, the
            Management Company shall see to the proper management and
            maintenance of the Common Areas, and it shall be agreed, inter alia,
            without limiting the generality of what is stated in Section 2.1:

<PAGE>

            2.3.1 To handle the lighting Machinery and networks, electricity
                  (provided the matter is not in violation of the directives of
                  the Electric Company), ventilation, air conditioning,
                  telephone and control, smoke detectors, emergency lighting,
                  generators, elevators, plumbing for electricity, water and
                  ventilation, drainage, sewage and all the other devices and
                  systems in the Building, and to see to it that these machines
                  and systems are maintained, and shall be in a proper condition
                  and capable of use.

            2.3.2 To deal with the cleaning of the Building, other than the
                  Units themselves, and including the machinery, the entrance,
                  the Common Areas, the bathrooms, the service rooms, windows,
                  doors, halls and the like, and to see to it that the Building,
                  with all its machinery, is clean and pleasing to the eye.

            2.3.3 To handle the carrying out of all the repairs, the
                  replacements, the connections, as well as the coordination of
                  the bringing into the Building and the taking out therefrom of
                  tangible property and objects.

            2.3.4 To organize and operate watchmen in the Building and outside
                  it, at a standard as shall be determined by the Management
                  Company.

            2.3.5 To insure the Building against various risks, according to the
                  decisions of the Management Company, as determined in Sections
                  14, 15 and 16 of this Agreement.

            2.3.6 To see to the arrangement of signs, keys and other Machinery
                  in the entrance and staircases, the halls and the bathrooms.

            2.3.7 To buy Machinery and equipment in order to install them in the
                  Building, according to their need, in order to manage and
                  maintain the Building in an appropriate manner.

            2.3.8 To handle the common systems found in the areas of the Unit
                  owners, in the hollow spaces created between the acoustic
                  ceiling and the concrete ceiling, as well as the hollow
                  pillars through which the pipes for water, sewage,
                  electricity, telephone, air conditioning and other things
                  pass. Subject to the provisions of Subsection 6.8 below, to
                  handle any request of the appropriate authorities with regard
                  to accessories (equipment and Machinery) o9f the protected
                  shelter areas on each floor (hereinafter: the "SHELTERS") and
                  the continuous maintenance of the foregoing accessories.
                  Except in times of emergency, the Management Company will see
                  to storing the Shelter accessories outside of the Unit areas
                  in which the Shelters are located. To the extent that the
                  possessors of the Units in which the Shelters are located
                  shall so request, after the delivery of possession of the
                  Unit, to carry out changes and coordination of any kind and
                  nature in the Shelter area, the Management Company shall carry
                  out the foregoing changes or coordination.

<PAGE>

            2.3.9  To store equipment and materials required to carry out the
                   provisions of this Contract in storage areas and other areas
                   that constitute part of the Common Area.

            2.3.10 To handle any other subject as is customary in office
                   buildings of the type such as the Building.

            The Services detailed in the subsections of Section 2.3 shall be
            included, for purposes of this Agreement, in the definition of the
            term "Services".

3.    TIME OF THE COMMENCEMENT OF CARRYING OUT THE SERVICES

      3.1   The Management Company commenced managing and rendering the Services
            in the Building on January 1, 1999 (hereinafter: the "EFFECTIVE
            DATE"). The Management Company commits to the Possessor to carry out
            and to manage the Services from the date of the delivery of the Unit
            to the Possessor within the meaning of this term in the Lease
            Agreement (hereinafter: the "DELIVERY DATE") until the time of the
            conclusion of the Lease Term, all subject to the terms of Section 20
            below.

      3.2   The Possessor covenants to bear all the obligations that apply to it
            by dint of this Agreement, including the payment of expenses and
            management fees, as defined in this Agreement, commencing with the
            Delivery Date, even if the Possessor has not yet occupied the Unit,
            provided that the failure to occupy the Unit is not the result of an
            act or failure to act on the part of the Landlord and/or the
            Management Company.

4.    REGULATIONS AND PROCEDURES

            The Possessor agrees that the Management Company shall from time to
            time determine procedures and regulations regarding the management
            and carrying out of the Services, as it shall deem appropriate,
            provided they do not expressly conflict with the terms of this
            Agreement and do not adversely affect the reasonable use of the
            Unit, and the Possessor covenants to act in accordance with them.

      4.1   The Management Company shall be entitled to determine rules of
            behavior that shall bind all the users in the Building's Units in
            order to preserve the standards of the Building and to prevent
            disturbances and nuisances to the possessors and users of the Units
            in the Building or to some of them.

      4.2   The Management Company shall be entitled to designate parking
            spaces, passageways, places to install television cables, antennas,
            gas canisters and the like in the Common Areas that will serve the
            Building or parts thereof.

      4.3   To Management Company shall be entitled to establish various
            procedures regarding entrance and exit arrangements, as well as the
            entrance of visitors to the Building, regarding security
            arrangements, regarding access procedures to the

<PAGE>

            Common Areas, regarding the manner of use of the Common Areas,
            procedures for the use of the parking garages and the like.

5.    MANAGEMENT COMPANY COVENANTS

      The Management Company hereby covenants:

      5.1   To employ a staff of technical, professional, administrative and
            other employees to carry out the tasks involving the management and
            providing the Services, and it will also be entitled to manage and
            carry out the Services, all or in part, through the use of
            contractors, subcontractors, experts, consultants, workers, or in
            any other manner as the Management Company shall decide, including
            employing people part time or full time, by a special employment
            contract or under other conditions -- all as the it shall in its
            discretion deem appropriate.

      5.2   The Management Company shall prohibit the conduct of a business in
            the Building that conflicts with the provisions of the law and/or
            which causes a nuisance, a malicious odor and the like to the other
            tenants of the Building.

      5.3   The Management Company shall maintain an office, with a phone
            connection, in which its administrative activities and the provision
            of the Services shall be concentrated.

      5.4   Separate and orderly accounting records shall be maintained in the
            office regarding the expenditures and receipts of the Management
            Company, including a separate card for the Possessor and the other
            acquirers of Units in the Building. The Possessor will be able,
            during customary office hours, to approach the office regarding any
            clarification or question relating to the management and provision
            of Services and regarding the activities of the Management Company,
            subject to the terms of Section 13 of this Agreement.

6.    POSSESSOR COVENANTS

      The Possessor hereby covenants:

      6.1   To contract only with the Management Company with all matters
            relating to the management and provision of Services in the Building
            pursuant to this Contract, to participate in the expenses connected
            with the provision of the Services and their management, on the
            basis of a coefficient that shall be determined by the Management
            Company, all as stated in the terms of this Agreement.

      6.2   To refrain from carrying out, whether on its own or through others,
            any activity or handling that was handed over by this Agreement to
            the Management Company, unless the Management Company agreed thereto
            in writing prior to the carrying out of the activity or the
            handling, or in the case in which the Management Company did not
            fulfill its obligations pursuant to this Agreement.
<PAGE>

      6.3   That it and those coming in its stead or on its behalf shall
            cooperate with the management Company and assist it in all instances
            in which such cooperation or assistance shall be required in order
            to permit the orderly and good management and provision of the
            Services.

      6.4   To itself carry out the regulations promulgated by the Management
            Company pursuant to Section 4 as aforesaid, and to see to it that
            all those who use the Unit with it, and all those who enter the
            Building on its behalf, also adhere to these regulations.

      6.5   To permit the Management Company and those coming in its stead, on
            prior coordination, to enter the Unit in order to carry out work in
            connection with the management and provision of the Services,
            whether those works are being done in connection with the
            Possessor's Unit or in connection with another unit in the Building,
            or for the purpose of carrying out repairs to the Common Area,
            including breaking walls, floors, ceilings and other parts, to
            replace and to fix plumbing, systems and other Machinery, to carry
            out any work required in the opinion of the managing Company in
            order to provide the Services in accordance with this Agreement. The
            Possessor shall not have any claim against the Management Company
            for disturbances that may be caused to him as a result of the
            foregoing. In any case of action as set forth above, the Management
            Company will attempt to keep the disturbance to the Possessor as
            limited as possible and to restore the Unit to its prior condition
            as quickly as possible.

            In order to avoid doubt, and without derogating from the generality
            of the foregoing, the Possessor hereby irrevocably grants the
            Management Company and all those acting on its behalf permission to
            enter the Unit at any reasonable time should the need therefor arise
            in order to clean the external covering.

      6.6   To promptly notify the Management Company of any defect that
            requires action on the part of the management Company.

      6.7   To consent to the recording of this Agreement in the Land Registry
            Office by attaching it to the Articles of Association of the
            cooperative building and/or to the long term lease deed and/or in
            any other manner, all at the discretion of the company or the
            Management Company.

      6.8   The Possessor is aware that in the case of an emergency it will have
            to vacate the reinforced room and/or the rooms that are included in
            the Unit that it leased and to make them available to all the users
            of the floor and/or the Building and therefore the Possessor
            covenants to vacate the reinforced room and/or rooms and make them
            available to the Management Company at any time that the Management
            Company directs by written notice given by the Management Company.
            Should the Possessor not have vacated the reinforced room and/or
            rooms at the time indicated by the Management Company, the
            Management Company shall be entitled to enter the reinforced room
            and/or rooms and empty them itself, without providing any additional
            notice to the Possessor. The Possessor is aware that in a
<PAGE>

            time of emergency and during the course of the period during which
            the possessors of Shelters will be required to vacate them for the
            good of all the users of the floor, those possessors will be exempt
            from the payment of management fees for the Shelter area.

6A.   JOINT ELECTRIC AND WATER METERS

      Without derogating from the generality of what is stated above, the
      Possessor acknowledges that it is aware that the costs of electric usage
      and water usage for the Common Areas and the Machinery shall apply to all
      the possessors of units in the Building.

7.    PAYMENT OF THE EXPENSES OF MANAGEMENT AND THE PROVISION OF SERVICES

      The Possessor covenants to pay the Management Company, together with the
      possessors of all the other units in the Building, all the expenditures
      and costs connected with the management and performance of the Services,
      including overhead expenses, the depreciation fund and management fees
      referred to in Section 8 below, and including all the expenses of the
      Management Company (all these shall be collectively referred to as: the
      "EXPENSES"). The Possessor's share of all the Expenses shall be in
      accordance with the area of the Possessor's Unit in relation to the
      aggregate of aggregate area of the units in the Building.

      7.1   If part of the Expenses were expended in connection with the
            Services or any part thereof that, in the opinion of the Management
            Company, are given or serve only a portion of the units in the
            Building and not all of them, the Management Company shall charge
            the possessors of those units or primarily them for such Expenses,
            according to a coefficient that it shall determine in its sole
            discretion. A written certificate signed by the accountants of the
            company shall serve as final and binding evidence of the coefficient
            for the division of the Expenses among the tenants of the Building.

      7.2   The Management Company shall include in the Expenses amounts
            intended to cover the depreciation of the Machinery and of the
            Common Areas and of the equipment, the systems and the Machinery of
            the Management Company required to provide the Services, in whole or
            in part, in the absolute discretion of the Management Company
            (hereinafter: the "DEPRECIATION FUND").

            The amounts of the Depreciation Fund shall be calculated as a
            deposit, and shall be retained by the Management Company in a
            separate account as trustees for all the possessors of units in the
            Building and shall serve to add to, to renew, and to replace
            equipment, systems and Machinery, and they shall not be returned to
            the possessors. The Management Company shall invest the Depreciation
            Fund money in solid investments as it deems appropriate.

            In the event that the Depreciation Fund shall be insufficient for
            additional, renewal or replacement of equipment, systems and
            Machinery, then the deficiency shall be made up by all possessors of
            units in the Building in the ratio among
<PAGE>

            them as detailed in Sections 7.1 and 7.2 above. It is agreed that
            the Management Company shall be entitled to replace and to renew
            equipment and Machinery in its absolute discretion.

      7.3   So as to avoid doubt, the Expenses shall include, without derogating
            from the generality of their definition, the wages of the employees,
            managers and consultants of the Management Company, as well as the
            general expenses of the Management Company of any kind, including
            for retaining attorneys, accountants and other advisers.

      7.4   All the Expenses of the Management Company and the payments they
            will be obligated to make in fact as a result of the breach of this
            Agreement by the Possessor and/or that will be required to enforce
            it or to take steps against it shall be paid by the Possessor to the
            Management Company at its first written request.

      7.5   So as to avoid doubt, it is emphasized hereby that all the Expenses
            and payments that are required in connection with the collection of
            the expenses from the possessors of the units in the Building, and
            in connection with the breach of the provisions of this Agreement or
            its enforcement against the possessors of units in the Building, as
            well as any financing expense of the Management Company in managing
            and performing the Services, including financing the purchase of
            equipment and Machinery required to perform the Services,
            constitutes part of the Expenses and shall be included therein.

      7.6   Pursuant to what is stated in this Section 7, if the Management
            Company operates and supplies special Services that will be made
            available to the tenants of the Building, such as the supply of
            food, drinks, cigarettes, newspapers, periodicals and books, writing
            implements, office supplies, snack bar and kiosk service, wash and
            rest rooms, conference rooms and lecture halls, waiting rooms, copy
            and photography rooms, parking services and parking garages and the
            like, such services shall not be included in the term "Expenses"
            pursuant to this Agreement, and the Management Company shall be
            entitled to operate these services for all interested parties and to
            receive payment therefor as it deems fit from those possessors who
            are interested therein.

      7.7   The refusal and/or unwillingness and/or lack of desire of a
            possessor to receive any particular Service and/or his desire to
            cease the management and provision of the Services pursuant to this
            Agreement, in whole or in part, will not exempt the possessor from
            its obligation to participate in the Expenses for managing and
            performing the Services in accordance with the terms of this
            Agreement.

8.    MANAGEMENT FEE AND VALUE ADDED TAX

      In consideration for the performance of the obligations of the Management
      Company pursuant to this Contract, it shall be entitled to a management
      fee at a rate of fifteen (15%) per cent of all the Expenses connected with
      the management and performance of the Services in the Building
      (hereinafter: the "MANAGEMENT FEE"). Management Fees
<PAGE>

      will be added to each invoice, will be paid by the possessor
      simultaneously with the payments detailed in Section 9 below, and shall be
      deemed, for all purposes, to be part of the Expenses of the management and
      performance of the Services.

      Value Added Tax shall be added to all payments of Expenses, the management
      and the performance of the Services, as stated in Section 9 above, as well
      as for the Maintenance Fees, at the rates that are customary at the time
      of the making of each payment in return for a tax receipt as required by
      law, which shall be issued by the Management Company. The Value Added Tax
      shall be paid simultaneously with the payment pursuant to this Agreement.

9.    PAYMENT TIMES

      The Possessor covenants to pay the Management Company its share of the
      Expenses in accordance with the invoice submitted to it by the Management
      Company within 7 days from the submission of the invoice. The invoice will
      be submitted to the possessor each month or each other period, as shall be
      determined by the management Company, and shall be based on its estimate
      of the Management Company's Expenses.

      The Possessor hereby covenants to pay the Management Company the Expenses
      and the deposit stated in Section 11 below, whether it itself is the
      occupier of the Unit or rented it or transferred the use therein to
      another, or if nobody at all makes use of the Unit.

      9.1   Within a period that shall not exceed six (6) months after December
            31 of each year, the Management Company shall prepare a final
            invoice of the Expenses regarding the prior fiscal year period
            (including the Depreciation Fund and Management Fee) (hereinafter:
            the "ANNUAL INVOICE"), and shall present a copy of such invoice to
            the Possessor. The Annual Invoice, when it is audited and approved
            by the management Company's accountants, shall serve as final and
            binding evidence of the amount of the Expenses.

      9.2   If the Annual Invoice shows a credit in favor of the Management
            Company, then the Possessor shall pay the Management Company the
            difference between the amounts the Possessor paid on account of his
            estimates share of the Expenses and the amount of the Expenses as
            stated on the Annual Invoice. The payment shall be made within 7
            days from the date on which the Management Company submitted the
            Annual Invoice to the Possessor. Should there be monetary
            differences for the benefit of the Possessor, the Management Company
            will credit its account with it accordingly.

10.   DEFAULT INTEREST

      The Possessor covenants to pay the Management Company for any delay
      whatsoever in payment under this Agreement at the maximum rate customary
      at that time at Discount Bank Ltd. For exceptional and unauthorized
      overdrafts from debitory accounts, or linkage differential to the Consumer
      Price Index (the General Index) together with linked interest at the rate
      of 8% per year, all according to the higher, all without derogating any
      right of the Management Company for any other remedy.

<PAGE>

11.   DEPOSIT

      The Possessor shall deposit with the Management Company on account of its
      share of the Expenses a deposit at the estimated level of the Expenses for
      three months in advance, that is to say, NIS 39,255 (based on the
      calculation: NIS 18.64 x 600 x 3 x 17%) (hereinafter: the "DEPOSIT"). The
      Deposit will be held by the Management Company, and it shall not be deemed
      to reduce the obligation of the Possessor to pay the amounts of the
      ongoing invoices submitted by the management Company. The Possessor
      covenants to pay the Management Company the Deposit amount no later than
      seven (7) days after the time of the receipt of the first written demand
      of the management Company.

      11.1  The Management Company shall be entitled to demand the deposit of
            the Deposit even prior to the Effective Date and this, inter alia,
            for the purpose of making various payments that are the obligation
            of the Management Company prior to the occupation of the Building.

      11.2  The Deposit will be returned to the Possessor upon the termination
            of the term of this Agreement, together with the return related
            thereto, as shall be determined by the accountant of the Management
            Company, subject to the provisions of Section 11.3 below.

      11.3  In the event that the Possessor does not comply with any timely
            payment as stated in this Agreement, then the Management Company
            shall be entitled, in its discretion, and without detracting from
            any other remedy to which it may be entitled, to use the Deposit
            funds to cover the aforesaid payment.

            In such a case, the Management Company shall be entitled to deduct
            from the Deposit the amount that is late, together with linkage
            differentials and/or interest, as set forth in Section 10 above.

      11.4  The Management Company shall be entitled to request from the
            Possessor from time to time to increase the amount of the Deposit,
            both in the case where the Management Company deducted from the
            Deposit sums that were in arrears and in the case where the
            Management Company believes the amount of the Deposit should be
            increased because the costs have increased, and the Possessor
            covenants to pay the Management company the requested sum no later
            than seven (7) days after the time of the receipt of the first
            written demand of the management Company.

      11.5  It is emphasized that the rate of Deposit that shall be paid by the
            Possessor pursuant to this Management Agreement shall not exceed the
            Deposit rate that the other tenants of the building shall pay, and
            that, proportionate to the size of the area each tenant possesses.

12.   MANAGEMENT COMPANY BOOKS

      The books, records, accounts of expenditures, reports, invoice collection
      documents, and the likes shall be kept in the offices of the management
      Company. The Management

<PAGE>

      Company covenants to keep separate and organized bookkeeping records
      regarding all the expenses and income, including a separate card for the
      Possessor and for each possessor of a unit in the Building. The Management
      Company shall employ a certified accountant to audit its books and prepare
      its balance sheets. The expense of the accountant shall be deemed to be an
      Expense.

      The Management Company books and its invoices shall be deemed to be and
      shall be accurate from the point of view of the Possessor and shall serve
      at all times as definitive proof with everything regarding the payments
      due from the Possessor and/or that were paid by the Possessor to the
      Management Company.

13.   INVOICES AND INQUIRIES

      The Possessor is entitled to receive an explanation with regard to the
      Expenses of managing the Services in the Building and regarding the
      bookkeeping books that relate thereto. The times for holding inquiries
      shall be determined by the Management Company in its discretion. The
      Possessor, together with other possessors of units in the Building, shall
      establish representatives for Building Maintenance matters and the
      provision of Services therein, and the Management Company shall maintain
      contacts with the foresaid representatives in order to make the Services
      more efficient and to improve them, on the one hand, and to save on
      Service management expenses, on the other.

14.   MANAGEMENT COMPANY LIABILITY

      The Management Company shall not bear any liability for any damage and/or
      loss that shall be caused to the Possessor as a result of a defect or flaw
      and/or cessation and/or delay in the supply of any of the other Services
      that the Management Company shall supply, if it supplies them, should the
      matter occur as a result of reasons not dependent on the Management
      Company and/or over which the Management Company has no control.

      14.1  The Services of the doorman and the reception in the Building shall
            be of a scope as shall be determined by the Management Company from
            time to time in its absolute discretion, and in any event the
            Management Company shall not be deemed to be a "keeper" of any kind
            whatsoever - over the Unit and/or its contents and/or any area
            included in the Building and/or the Common Areas and/or the
            Machinery, for the purpose of, and/or in connection with the
            Keeper's Law, 5727-1967 and/or the liability under that law and/or
            liability of a similar type, whether contractual, in tort, or
            otherwise.

      14.2  Despite what is stated, the Management Company shall be entitled to
            insure its potential liability of any kind for any damages and
            against any third party whatsoever. In addition, the Management
            Company shall be entitled to insure all its employees in performing
            the Services in an employee policy, employer liability, and
            severance pay fund and any other insurance of a similar type.

      14.3  In any of the events detailed in this Section 14, all the premiums
            and the expenditures connected with the insurance shall be deemed to
            be part of the Expenses of the Management Company.

<PAGE>

15.   INSURANCE ON THE PART OF THE MANAGEMENT COMPANY

      15.1  The Management Company will see to the insurance of the structure of
            the Building and/or the Common Areas and/or the Machinery with a
            building insurance against customary risks in an amount as shall be
            determined by the Management Company in its discretion.

            For the avoidance of doubt: It is agreed that the Management Company
            shall not see to the insurance of the contents of the Unit and
            improvements and/or additions that were made by the Possessor for
            damages of any kind or sort whatsoever.

      15.2  The Management Company will see to third party liability insurance
            for the Building structure and/or the Common Areas and/or the
            Machinery, with liability limits as the Management Company shall
            determine in its discretion.

            For the avoidance of doubt: It is agreed that the Management Company
            shall not see to liability insurance of the Possessor for any third
            party risks that are connected to any act and/or failure to act
            and/or incident related to the Unit and/or the possession thereof,
            and the responsibility for the insurance of such risks shall fall
            solely on the Possessor.

      15.3  The Management Company will see to employer liability insurance for
            its employees.

      15.4  Notwithstanding what is stated in this Section 15, the Management
            Company shall be entitled, in its sole discretion, to insure the
            Building and/or the Common Areas and/or the Machinery for additional
            risks as well, as it shall deem it appropriate.

      15.5  In any case in which the Management Company insures risks as stated
            in Sections 15.1, 15.2, 15.3 and 15.4 above, all premiums paid and
            expenditures connected with the insurance as aforesaid shall be
            deemed to be Expenses as defined in Section 7 of this Agreement.

      15.6  At the request of the Possessor, the Management Company will show
            him, in the offices of the Management Company, the insurance
            policies it acquired (hereinafter: the "INSURANCE POLICIES").

      15.7  The Insurance Policies will list the Possessor as one of the
            insureds or, alternatively, will contain a provision that, pursuant
            thereto, the insurance company waives its right of subrogation
            against the Possessor, and in the case of third party insurance, it
            will include a cross-liability provision.

      15.8  Should damage be caused to the Unit and/or to the Building that
            requires rehabilitation and that is covered in accordance with the
            insurance policy, the Management Company shall be the exclusive
            possessor of the right to negotiate with the insurers, to sue them,
            to compromise with them, and to receive the insurance proceeds.

<PAGE>

            In the event that the amount received will be inadequate to cover
            the repair expenses, the purchaser shall share in the additional
            expenses, in accordance with the set coefficient for bearing
            expenses. The Management Company shall hold the insurance proceeds
            that it shall receive, as aforesaid, and shall use them for the
            purpose of replenishing the Building, including the Unit.

      15.9  The Possessor agrees and hereby acknowledges that the taking out of
            any kind of insurance as aforesaid in the provisions of this
            Agreement does not impose, and shall not impose, on the Management
            Company any liability regarding the type of insurance policy that it
            should take out and/or regarding the reliability of the insurance
            company that is insuring under that policy and/or the financial
            stability of that insurance company and/or any other liability
            connected with the carrying out of the aforesaid insurance.

16.   INSURANCE ON THE PART OF THE POSSESSOR

      The Possessor covenants to insure, from the date of the delivery of the
      Unit, and at its expense, insurances as detailed below, with lawfully
      authorized insurance companies and the provisions detailed below shall
      apply:

      16.1  Insurance of the contents of the Unit and all other property
            contained therein, and without derogating from the generality of the
            foregoing, the furniture, equipment, Machinery and inventory
            contained therein, as well as any change, improvement, renovation
            and addition to the Unit that was made and/or will be made to the
            Unit by the Possessor and also/or for it, of any kind or sort
            whatsoever, all the foregoing having an estimated value of the loss
            or damage in light of customary risks. The Possessor covenants to
            update the amount of the insurance from time to time so that it
            always reflects the full value of the insured property.

            The Possessor covenants that the policy that it will obtain shall
            include a specific condition in which the insured specifically
            waives any right to subrogation against the Management Company
            and/or those acting on its behalf and/or the possessors in the
            Building and/or all those acting on their behalf.

            The purchaser hereby exempts the management Company and all those
            acting on its behalf, as well as all the possessors in whose
            Management Agreement with them is included a parallel exemption for
            all the purchasers in the Building, for any liability for loss or
            damage for which the Possessor is entitled, or for which the
            Possessor would be entitled to indemnification pursuant to the
            policy.

      16.2  To insure the activities of the Possessor and the Management Company
            within the Unit with employer's liability insurance and third party
            liability insurance, where the liability limit for third party
            liability insurance shall not be less than $500,000 (five hundred
            thousand U. S. Dollars) per incident. The Possessor hereby covenants
            that each third party and employer's insurance that shall be
            acquired by it pursuant to this Agreement shall be subject to a
            "cross-liability" provision

<PAGE>

            according to which the insurance shall be deemed to have been
            entered into separately for each and every one of the insured's
            units.

            The Possessor hereby covenants to expand the employer's and third
            party policies to indemnify the Management Company and also/or those
            acting on its behalf for their agency liability for the acts and
            also/or the failures to act on the part of the Possessor.

      16.3  The Possessor covenants to fulfill all the terms of the policy that
            it takes out in connection with the provisions of Section 16 of this
            Agreement, and to pay the premiums on time.

      16.4  The Possessor hereby represents that it will not have any contention
            and/or claim against the Management Company and/or those acting on
            its behalf for damages in light of the risks that the Possessor
            committed itself to insure as aforesaid in the subsections of
            Section 16, and it exempts the management Company and/or those
            acting on its behalf from any liability for damages as aforesaid.

      16.5  The provisions of Section 16 above, including the scope of the
            insurances, are subject to the comments of the Possessor's insurance
            consultant or agent and the condition that these shall be
            transmitted to the Landlord in writing within 30 days from the date
            of the execution of this Contract. An amendment to the provisions of
            this Section 16 will be made, if at all, upon the agreement of the
            insurance consultants of the parties.

17.   SEPARATION OF PARTS OF THE BUILDING

      If and when it shall be decided by the company on the separate management
      of certain parts of the Building (hereinafter: the "UNIQUE PART"), then
      the Management Company shall be entitled:

      17.1  To set separate provisions for the giving of Services and management
            of the Unique Part.

      17.2  To set separate provisions for supervision, security, use,
            maintenance, management, and the providing of Services in the Common
            Areas and separate regulations for the Unique Part.

      17.3  To set a separate division of the Expenses with regard to the Unique
            Part and in accordance with a coefficient that it will set, to the
            extent possible according to the measure of the use of the Services
            and their actual costs.

      17.4  To set regulations with regard to the permitted use in the Unique
            Part.

      17.5  For the avoidance of doubt, it is emphasized that there will not be
            imposed on the Possessor or on the Management Company any monetary
            liability of any kind or sort whatsoever for the Unique Part and its
            maintenance.

<PAGE>

18.   TRANSFER OF THE POSSESSOR'S RIGHTS

      The Possessor hereby covenants that if it sells, rents or purchases in
      another manner whatsoever possessory and/or use rights in the Unit to any
      other entity (hereinafter: the "RECEIVER OF THE RIGHTS"), for any period
      of time (whether limited or unlimited), it shall be obligated, prior to
      signing the contract between it and the Receiver of the Rights, and in any
      case prior to the transfer or purchase of the foregoing rights, and at a
      time that shall be set by the Management Company, to see to it that the
      Receiver of the Rights signs with the Management Company or with whomever
      it directs on a Management Agreement in a form acceptable at that time to
      the Management Company.

      Except in the case of the sale of the rights of the Possessor in the Unit,
      the execution of the aforesaid Management Agreement by the Receiver of the
      Rights shall not release the Possessor from carrying out its obligations
      pursuant to this Agreement, and it shall be liable, jointly and severally
      with the Receiver of the Rights, for fulfilling all the obligations
      pursuant to this Agreement.

19.   TRANSFER OF THE MANAGEMENT COMPANY'S RIGHTS

      The Management Company shall be entitled to transfer and also/or to assign
      and also/or to deliver its rights and obligations under this Management
      Agreement, including any supplement or amendment thereto, and anything
      arising thereunder, to another management company or to another entity,
      that exists or that will be established for that purpose, in full or in
      part, with regard to the entire original term or the extended period or
      any part thereof. Should the Management Company have transferred its
      rights and obligations, it shall receive from the other management company
      or the other entity designated therefor, prior to the transfer, a written
      acknowledgement according to which the other management company or the
      other entity will assume the fulfillment of all the obligations of the
      Management Company under this Management Agreement, and a copy of this
      letter will be transmitted to the Possessor and to other possessors in the
      Building. If the rights and obligations under this Management Agreement,
      including every addition and amendment and all that flows from it is
      transferred and/or assigned and/or delivered to another management company
      or another entity, then the Management Company shall not have any
      liability whatsoever toward the Possessor.

20.   TERM OF THE CONTRACT

      This Management Agreement is entered into for a term of five (5) years,
      commencing on the Effective Date, and until January 1, 2004 (hereinafter:
      the "ORIGINAL TERM"), and subject to the terms of Sections 20.1 and 20.2
      below, the Original Term shall be extended, without any need for a formal
      act for an additional term or terms of five (5) years each (hereinafter:
      the "EXTENDED TERM").

      20.1     Notwithstanding what is stated in this section above, this
               Agreement shall terminate at the end of the Original Term or at
               the end of the Extended Term if at least 75% of the unit owners
               in the Building gave a written notice to the Management Company
               of their desire to terminate this Agreement at least six (6)

<PAGE>

              months prior to the end of one of the foregoing terms, and on
              condition that the possessors fulfill all their obligations and
              the payments that are due at that time to the Management Company,
              and that they relieve the Management Company of the obligations it
              took upon itself in connection with the management and performance
              of the Services toward all third parties regarding the period
              after the termination of this Agreement, as aforesaid.

      20.2    The provisions of Sections 20 and 20.1 above and below
              notwithstanding, the Management Company shall be entitled to
              terminate this Agreement at any time on at least six (6) months'
              prior written notice to the possessors of the units in the
              Building. A written notice displayed in a centrally located and
              clearly visible place in the Building shall be deemed to be the
              giving of notice for the purposes aforesaid in this section.

      The provisions of this Section 20 above notwithstanding, this Agreement
      shall commence on the Delivery Date and shall terminate at the end of the
      Lease Term (the first, the second or the third, as the case may be)
      according to the Lease Agreement or in the case of the lawful cancellation
      of the Lease Agreement by the Possessor or the Landlord.

21.   BREACH AND REMEDIES

      21.1  If the Possessor breached any of the provisions included in this
            Agreement and does not cure the breach within seven (7) days after
            it receives the demand of the Management Company to do so, or if the
            Possessor repeats the same breach, then the Management Company shall
            be entitled, inter alia, to terminate the giving of Services to the
            Possessor, in whole or in part, in its absolute discretion.

      21.2  Nothing contained in the terms of this section shall be deemed to
            negatively affect the right of the Management Company to any other
            relief pursuant to the Contracts Law (Remedies for Breach of
            Contract) 5731-1970, or pursuant to any law.

      21.3  The Possessor hereby waives, and will not raise and/or claim against
            the Management Company in regard to all the foregoing, whether
            directly or indirectly, any contention regarding the division of
            causes of action and/or the division of remedies.

22.   The Possessor covenants to bear the costs of stamping this Agreement as
      required by law.

23.   ARBITRATION

      In any case in which disputes arise and/or differences between the parties
      with anything regarding the execution and/or the effectiveness or breach
      and/or the carrying out and/or the interpretation of this Lease, the
      parties will submit the disputes or the differences for the determination
      of a sole arbitrator who shall be appointed by agreement of the parties
      within seven (7) days, and should the agreed upon arbitrator refuse to
      serve or be prevented from fulfilling his task or in the case of
      disagreement between the parties as to the identity of the arbitrator, the
      arbitrator shall be appointed by the Chairman of the

<PAGE>

      Israel Bar Association, at the request of one of the parties (hereinafter:
      the "ARBITRATOR").

      23.1  The provisions of this Section 23 shall be deemed to be an
            arbitration agreement between the parties, and the provisions of the
            Addendum to the Arbitration Law, 5728-1968, shall apply to the
            arbitration that is the subject of this Agreement, as well as to the
            Arbitrator.

      23.3  If, and to the extent, that there shall be parallel and/or similar
            disputes between the Management Company and the Possessor and other
            possessors of units in the Building, these disputes will be
            submitted to the Arbitrator, and the Arbitrator will be entitled, in
            order to detail the procedures and to shorted them, to combine the
            similar and/or parallel disputes and to rule on them as one unit.

      23.4  A referral to the Arbitrator or the engaging in arbitral proceedings
            shall not give rise to the delay and/or postponement of the making
            of any payment whatsoever as to which the Possessor is obligated
            under the provisions of this Agreement , and nothing contained in
            the provisions of this Section 23 shall derogate from the right of
            the Management Company to sue the Possessor in a court having
            jurisdiction regarding the making of any payment which is due from
            the Possessor pursuant to this Agreement.

24.   MISCELLANEOUS

      24.1  Should one of the units of the Possessor sign any document, letter
            or acknowledgement of any kind whatsoever with regard to any matter
            or subject connected with this Agreement, its fulfillment or what
            flows from it, its signature shall bind the rest of the units of the
            Possessor, and the execution of this Agreement by one of the units
            of the Possessor shall be deemed, for all intents and purposes, to
            be the consenting by the units of the Possessor, among themselves,
            and from one to the other, to bind the other units of the Possessor
            among themselves for each matter and subject connected with this
            Agreement.

      24.2  This Agreement and the exhibits thereto crystallize and express the
            relationship, the rights and the obligations between the Possessor
            and the company exclusively and totally.

      24.3  Upon the execution of this Agreement, which constitutes the entire
            and binding agreement between the parties, any agreement and/or
            heads of agreement and/or understanding and/or representation and/or
            prospectus and/or promise and/or advertisement that was made by the
            company or the Management Company or their representatives or
            someone on their behalf shall be null and void, and the company and
            the Management Company shall not be bound by any of them.

            The parties hereby represent that they reached this Agreement after
            careful examination, and that neither side relied on any information
            other than that which is expressly stated in this Agreement.

<PAGE>

      24.4  The marginal headings of the sections in this Agreement are for the
            convenience purposes only, and shall not serve as any reference or
            tool to explain and/or interpret this Agreement.

      24.5  Prior drafts of this Agreement shall not be given any weight
            regarding the interpretation of this Agreement or any of its
            provisions. Such drafts shall not be admissible in any judicial or
            quasi-judicial procedure.

      24.6  No one of the provisions included in this Agreement shall derogate
            from any other provision of this Agreement but rather to add
            thereto.

      24.7  No change and/or waiver and/or deviation from the provisions of this
            Agreement shall have any effect unless done in writing and signed by
            the parties to the Agreement.

      24.8  The consent by one of the parties to a deviation from one of the
            provisions of this Agreement in a particular case shall not
            constitute a precedent or give rise to an analogy for any other
            event. If a party did not avail itself of a right granted to it
            under this Agreement in a particular case, it shall not be viewed as
            a waiver of that right in that case and/or in a similar or
            dissimilar case, and one may not assume therefrom a waiver of any
            kind of any right by that party.

      24.9  It is expressly agreed by the parties that, subject to the
            provisions of Section 23 of this Agreement, the courts of Tel Aviv -
            Jaffa shall have exclusive jurisdiction to hear any dispute and/or
            argument that arises between the parties in relation to this
            Agreement, its execution, term, fulfillment, breach or
            interpretation.

      24.10 The addresses of the parties for purposes of this Agreement are as
            expressed in the heading to this Agreement, and any notice sent by
            one party to the other by registered mail according to the above
            addresses, unless a party notified the other of a change therein,
            shall be deemed to have reached its destination and been brought to
            the knowledge of the recipient within 72 hours from its dispatch in
            the mail.

          IN WITNESS WHEREOF, THE PARTIES HAVE EXECUTED THIS AGREEMENT
                  IN THE PLACE AND AT THE TIME MENTIONED ABOVE:

/s/ SH.A.P. -- EMAD
Management Company Ltd.                                        /s/ SILVIA NOIMAN
                                                               -----------------
the Management Company                                           the Possessor<PAGE>

                                                                    Exhibit 10.8

           PREDIX PHARMACEUTICALS HOLDINGS, INC. EMPLOYMENT AGREEMENT

      EMPLOYMENT AGREEMENT, dated as of the 8th day of August, 2003 (the
"Effective Date") between Predix Pharmaceuticals Holdings, Inc., a Delaware
corporation with its principal place of business at 10 K Gill Street, Woburn, MA
01801 (the "Company"), and Dr. Michael Kauffman residing at [ADDRESS] (the
"Employee").

                                   WITNESSETH:

      WHEREAS, the Company desires to employ the Employee as President and Chief
Executive Office ("CEO") of Predix Pharmaceuticals, Inc. and the Employee
desires to accept such employment, all on the terms and conditions specified
herein; and

      WHEREAS, the Employee and the Company desire to set forth in writing all
of their respective duties, rights and obligations with respect to the
Employee's employment by the Company; and

      NOW, THEREFORE, in consideration of the foregoing and of the mutual
covenants and obligations hereinafter set forth, the parties hereto, intending
to be legally bound, hereby agree as follows:

      1. Employment. The Company hereby offers to employ the Employee, and the
Employee hereby accepts employment by the Company, in the capacity and upon the
terms and conditions hereinafter set forth.

      2. Duties. The Employee shall serve as the President and CEO for the
Company and any affiliate or subsidiary of the Company determined by the
Company's Board of Directors, and shall perform such duties, functions and
responsibilities as are associated with and incident to that position and as the
Company may, from time to time, require of him. The Employee shall serve the
Company faithfully, conscientiously and to the best of the Employee's ability
and shall promote the interests and reputation of the Company. Unless prevented
by sickness or disability, the Employee shall devote all of the Employee's time,
attention, knowledge, energy and skills, during normal working hours, and at
such other times as the Employee's duties may require, to the duties of the
Employee's employment. The principal place of employment of the Employee shall
be at Employer's Woburn, MA area office and/or such other location as shall be
necessary for the Employee to discharge the Employee's duties hereunder. The
Employee acknowledges that in the course of employment the Employee may be
required, from time to time, to travel on behalf of the Company. The Company
recognizes that the Employee will continue to fulfill his responsibilities as
President of OutlineMed Inc., a medical software company at 25 Kerr Path,
Newton, Massachusetts, which, at this time, is wholly-owned by the Employee,
provided that such responsibilities do not interfere with the Employee's
fulfillment of his duties and obligations to the Company, its affiliates and
subsidiaries as outlined in this Agreement or otherwise.

<PAGE>

      3. Compensation and Benefits. As full and complete compensation for the
Employee's execution and delivery of this Agreement and performance of any
services hereunder, the Company shall pay, grant or provide the Employee, and
the Employee agrees to accept, the following compensation and benefits, which
shall be paid by the Company or any of its affiliates or subsidiaries designated
by the Company:

            a. Base Salary. The Company shall pay the Employee a base salary at
an annual rate of $300,000.00 payable on the 15th and last day of every month,
in accordance with the Company's customary payroll practices that may be adopted
or modified from time to time. On an annual basis or at such other times as the
Company may determine, the Company will review the Employee's performance and
determine whether, in its sole discretion, the Company will increase (but not
decrease, except that such salary may be decreased if in connection with a
decrease in the salaries of all similarly situated Company executives) the
Employee's base salary.

            b. Bonus. The Employee may be eligible for bonuses from the Company
during the course of his employment. The timing and amount of such bonus(es), if
any, shall be in the sole discretion of the Company. The criteria to be used in
determining any such bonus may include, in the Company's discretion, one or more
of the following criteria: individual performance, performance of specific
projects, and the Company's performance. The Employee will also be eligible for
the following specific bonuses: (i) upon the closing of the transaction in which
the Company shall take ownership of 100% of the shares of Predix Ltd., and after
the Effective Date, the Employee will be eligible for a one-time special bonus
of $30,000.00, to be paid on or before thirty days from the Effective Date; and
(ii) during the twelve month period ending July 31, 2004, the Employee will be
eligible for a performance based bonus, to be based upon the Company and the
Employee meeting milestones to be set by the Board of Directors. The target
amount of the bonus in subsection (ii) shall be $70,000.00, although the Board
in the exercise of its sole discretion shall determine the actual bonus payment.

            c. Fringe Benefits. The Company shall afford the opportunity to
participate in any health care, dental, disability insurance, retirement,
savings and any other employee benefits plans, policies or arrangements which
the Company maintains for its employees in accordance with the written terms of
such plans, policies or arrangements, so long as the Employee meets all
applicable eligibility requirements. Nothing in this Agreement shall require the
Company or its affiliates to establish, maintain or continue any benefit plans,
policies or arrangements or restrict the right of the Company or any of its
affiliates to amend, modify or terminate any such benefit plan, policy or
arrangement.

            d. Stock and Stock Option Arrangements. All of the Employee's stock
and stock options shall be governed by the applicable stock plan and stock
option or stock agreement, which provisions shall supersede any statements in
this section.

Subject to the approval of the Compensation Committee of the Company's Board of
Directors, the Company shall grant to the Employee an option to purchase shares
of the Company's common stock. Each grant shall be pursuant to the terms and
conditions of the Predix Pharmaceuticals Holdings, Inc. 2003 Stock Incentive
Plan and the Employee's execution of a

                                        2
<PAGE>

standard Predix Pharmaceuticals Stock Option Agreement in the form provided to
the Employee by the Company. The Employee acknowledges having received a copy of
the Predix Pharmaceuticals Holdings, Inc. 2003 Stock Incentive Plan and
unexecuted Stock Option Agreements.

The Employee will be granted 1,069 shares as a grant of Predix Holdings A Common
shares. These shares shall be unrestricted.

The Employee will also be granted 431,572 options to purchase Predix Holdings A
Common shares, vesting over 4 years from September 23, 2002 with an exercise
price of $0.10 per share. These options will be governed by the Predix
Pharmaceuticals Holdings, Inc. 2003 Stock Incentive Plan and the related option
agreement. The deal valuation per share of A Common Stock is $0.10.

The Employee will also be granted a further 325,450 options to purchase Predix
Holdings A Common shares, vesting over 4 years from July 31, 2003 with an
exercise price of $0.10 per share. These options will be governed by the Predix
Pharmaceuticals Holdings, Inc. 2003 Stock Incentive Plan and the related option
agreement. The deal valuation per share of A Common Stock is $0.10.

            e. Expenses. The Employee shall be entitled to reimbursement or
payment of reasonable business expenses in accordance with the Company's
policies, as the same may be amended from time to time in the Company's sole
discretion, following the Employee's submission of appropriate receipts, bills
and/or expense reports to the Company in accordance with such policies.

            f. Time Off. The Employee shall be entitled to twenty (20) WYN (What
You Need) days per calendar year, without loss or diminution of compensation.
These WYN days shall accrue at the rate of 1.67 WYN days per full month of
service, commencing with the Effective Date of this Agreement. Such WYN days
shall be taken at such time or times consistent with the needs of the Company's
business and in accordance with the Company's policies. The Employee shall
further be entitled to the number of paid holidays, and leaves in accordance
with the Company's policies as such policies may be amended from time to time or
terminated in the Company's sole discretion. The Company currently allows for
eleven (11) paid holidays per calendar year.

      4. Non-Competition, Confidentiality, Discoveries and Works:

            a. Non-Competition: During the period of the Employee's employment
at the Company and for six (6) months following the termination, for any reason,
of the Employee's employment, the Employee agrees not to compete in any manner,
either directly or indirectly, whether for compensation or otherwise, with the
Company, or to assist any other person or entity to compete with the Company
either:

                  (i) by producing, developing or marketing, or assisting others
to produce, develop or market, or

                                        3
<PAGE>

                  (ii) by accepting employment from or having any other
relationship (including, without limitation, through owning, managing,
operating, controlling or consulting) with any entity: (Y) which produces,
develops or markets, a product, process, or service which is competitive with
those products, processes, or services of the Company, whether existing or
planned for in the future; or (Z) on which the Employee has worked, or
concerning which the Employee has in any manner acquired knowledge of or had
access to Confidential Information (as defined in Section 4(e)(iii) below),
during the three (3) years preceding termination of the Employee's employment.
Except that the Employee may have beneficial ownership of less than 1% of the
outstanding amount of any class of securities listed on a national securities
exchange or quoted on an inter-dealer quotation system, of such a company.

            b. Non-Solicitation: During the period of the Employee's employment
at the Company and for twelve (12) months following the termination, for any
reason, of the Employee's employment, the Employee agrees that the Employee will
not, either on the Employee's own behalf or on behalf of any other person or
entity (other than for the benefit of the Company), directly or indirectly, (i)
solicit any person or entity that is a customer of the Company, or has been a
customer of the Company during the prior twelve (12) months, to purchase any
products or services the Company provides to the customer, or (ii) interfere
with any of the Company's business relationships.

            c. No-Hire: During the period of the Employee's employment at the
Company and for twelve (12) months following the termination, for any reason, of
the Employee's employment, the Employee agrees that the Employee will not,
either on the Employee's own behalf or on behalf of any other person or entity,
directly or indirectly, hire, solicit or encourage to leave the employ of or
engagement by the Company any person who is then an employee or contractor of
the Company or who was an employee or contractor of the Company within six (6)
months of the date of such hiring, soliciting, or encouragement to leave the
Company.

            d. Geographic Scope: The foregoing restrictions shall apply in the
"Restricted Area" which means:

                  (i) any competitive business anywhere in the world, given the
nature of the Company's business and certain accounts of the Company are
national and international in scope and are not dependent on the geographic
location of the Employee personnel or the business by which they are employed,
and

                  (ii) any location, storefront, address or place of business
where a Covered Customer is present and available for solicitation.

The Employee will not circumvent the purpose of any restriction contained in
Section 4(a), 4(b) or 4(c) by engaging in business outside the geographic region
covered by the above definition through remote means like telephone,
correspondence or computerized communication. "Covered Customer" means those
customers, entities and/or persons who did business with the Company and that
the Employee either (x) received Confidential Information about in the course

                                        4
<PAGE>

of his/her duties, (y) had contact with within the last twenty-four (24) month
period of employment by the Company, or (z) supervised contact with within the
last twenty-four (24) month period of employment with the Company.

      e. Confidentiality:

                  (i) During the period of the Employee's employment at the
Company and for all time following the termination, for any reason, of the
Employee's employment, the Employee shall hold all Confidential Information of
the Company in a fiduciary capacity and agrees not to take any action which
would constitute or facilitate the Unauthorized use or disclosure of
Confidential Information.

The Employee further agrees to take all reasonable measures to prevent the
Unauthorized use and disclosure of Confidential Information and to prevent
Unauthorized persons or entities from obtaining or using Confidential
Information. The terms "Confidential Information" and "Unauthorized" shall have
the meanings set forth in Sections 4(e)(iii) and (iv) of this Agreement
respectively.

                  (ii) Promptly upon termination, for any reason, of the
Employee's employment with the Company, the Employee agrees to deliver to the
Company all property and materials within the Employee's possession or control
which belong to the Company or which contain Confidential Information.

                  (iii) As used in this Agreement, the term "Confidential
Information" shall mean trade secrets, confidential or proprietary information,
and all other information, documents or materials, owned, developed or possessed
by the Company, its parents, subsidiaries or affiliates, their respective
predecessors and successors, whether in tangible or intangible form, that is not
generally known to the public. Confidential Information includes, but is not
limited to, (a) financial information, (b) products, (c) product and service
costs, prices, profits and sales, (d) new business ideas, (e) business
strategies, (f) product and service plans, (g) marketing plans and studies, (h)
forecasts, (i) budgets, (j) projections, (k) computer programs, (l) data bases
and the documentation (and information contained therein), (m) computer access
codes and similar information, (n) software ideas, (o) know-how, technologies,
concepts and designs, (p) research projects and all information connected with
research and development efforts, (q) records, (r) business relationships,
methods and recommendations, (s) existing or prospective client, customer,
vendor and supplier information (including, but not limited to, identities,
needs, transaction histories, volumes, characteristics, agreements, prices,
identities of individual contacts, and spending, preferences or habits), (t)
training manuals and similar materials used by the Company in conducting its
business operations, (u) skills, responsibilities, compensation and personnel
files of Company employees, directors and independent contractors, (v)
competitive analyses, (w) contracts with other parties, and (x) other
confidential or proprietary information that has not been made available to the
general public by the Company's senior management.

                  (iv) As used in this Agreement, the term "Unauthorized" shall
mean: (a) in contravention of the Company's policies or procedures; (b)
otherwise inconsistent with the

                                        5
<PAGE>

Company's measures to protect its interests in the Confidential Information; (c)
in contravention of any lawful instruction or directive, either written or oral,
of a Company employee empowered to issue such instructions or directive; (d) in
contravention of any duty existing under law or contract; or (e) to the
detriment of the Company.

                  (v) In the event that the Employee is requested by any
governmental or judicial authority to disclose any Confidential Information, the
Employee shall give the Company prompt notice of such request (including, by
giving the Company a copy of such request if it is in writing), such that the
Company may seek a protective order or other appropriate relief, and in any such
proceeding the Employee shall disclose only so much of the Confidential
Information as is required to be disclosed.

            f. Discoveries and Works. All discoveries and works made or
conceived by the Employee during and in the course of his/her employment by the
Company, jointly or with others, that relate to the Company's activities shall
be owned by the Company. The terms "discoveries and works" include, by way of
example, all ideas, discoveries, creations, manuscripts and properties,
innovations, improvements, know-how, inventions, designs, developments,
apparatus, techniques, methods, biological processes, cell lines, laboratory
notebooks and formulae, whether or not patentable or copyrightable, including
all rights to obtain, register, perfect and enforce these proprietary interests.
The Employee shall promptly notify and make full disclosure to, and execute and
deliver any documents requested by, the Company to evidence or better assure
title to such discoveries and works by the Company, assist the Company in
obtaining or maintaining for itself at its own expense United States and foreign
patents, copyrights, trade secret protection and other protection of any and all
such discoveries and works, and promptly execute, whether during his/her
employment or thereafter, all applications or other endorsements necessary or
appropriate to maintain patents and other rights for the Company and to protect
its title thereto. Any discoveries and works which, within one (1) year after
the termination of the Employee's employment hereunder, are made, disclosed,
reduce to a tangible or written form or description, or are reduced to practice
by the Employee and which pertain to work performed by the Employee while with,
and in his/her capacity as an Employee of, the Company shall, as between the
Employee and the Company presumed to have been made during the Employee's
employment by the Company.

            g. Representations, Warranties and Acknowledgements

                  (i) The Employee acknowledges that (a) the Company considers
Confidential Information to be commercially and competitively valuable to the
Company and critical to its success; (b) Unauthorized use or disclosure of
Confidential Information would cause irreparable harm to the Company; and (c) by
this Agreement, the Company is taking reasonable steps to protect its legitimate
interests in its Confidential Information.

                  (ii) The Employee also acknowledges the competitive and
proprietary nature of the Company's business operations. The Employee
acknowledges and agrees that a business will be deemed competitive with the
Company if it engages in a line of business in which it performs any of the
services, conducts research, or develops, manufactures or sells any products
provided or offered by the Company or under development by the Company, or any

                                        6
<PAGE>

similar products or products fulfilling the same function, whether or not
similar, in the Field of Interest (such business to be referred to as a
"competitive business"). The term "Field of Interest" currently means discovery
and development of drugs acting on G Protein Coupled Receptors and Ion Channels.
The Employee further understand that the Company may expand the definition of
its Field of Interest at any time by action of the Board of Directors, which new
definition will be binding upon the Employee ten (10) days after written notice
to the Employee of such change.

The Employee further acknowledges that given the nature of the Company's
business, certain accounts of the Company are national and international in
scope and are not dependent on the geographic location of the Employee personnel
or the business by which they are employed.

                  (iii) The Employee represents and warrants to the Company that
he/she is not a party to any agreement, or non-competition or other covenant or
restriction contained in any agreement, commitment, arrangement or understanding
(whether oral or written), that in any way conflicts with or limits the
Employee's ability to commence or continue to render services to the Company or
that would otherwise limit the Employee's ability to perform all
responsibilities in accordance with the terms and subject to the conditions of
the Employee's employment.

                  (iv) The Employee acknowledges that certain accounts are
national and international in scope and the location of the Company's customers
is not dependent on the geographic location of the Employee or the Company.

                  (v) The Employee consents and agrees that, during the
Employee's employment with Company and thereafter, the Company may review,
audit, intercept, access and disclose all communications created, received or
sent over the electronic mail and internet access system provided by Company
with or without notice to the Employee and that such review, audit,
interception, access, or disclosure may occur during or after working hours. The
Employee further consents and agrees that the Company may, at any time, access
and review the contents of all computers, computer disks, other data storage
equipment and devices, files, desks, drawers, closets, cabinets and work
stations which are either on Company's premises or which are owned or provided
by Company.

            h. Remedies. In the event of breach or threatened breach by the
Employee of any provision of Section 4 hereof, the Company shall be entitled to
obtain (i) temporary, preliminary and permanent injunctive relief, in each case
without the posting of any bond or other security, (ii) damages and an equitable
accounting of all earnings, profits and other benefits arising from such breach,
or threatened breach, (iii) recovery of all attorney's fees and costs incurred
by the Company in obtaining such relief, (iv) repayment of any severance
benefits paid to the Employee pursuant to this Agreement or any severance
benefit agreement, plan or arrangement of the Company, and (v) any other legal
and equitable relief to which it may be entitled, including any and all monetary
damages which Company may incur as a result of said breach or threatened breach.
The Company may pursue any remedy available, including declaratory relief,
concurrently or consecutively, in any order, and the pursuit of one such

                                        7
<PAGE>

remedy at any time will not be deemed an election of remedies or waiver of the
right to pursue any other remedy.

            i. Early Resolution Conference. This Agreement is understood to be
clear and enforceable as written and is executed by both parties on that basis.
However, should the Employee later challenge any provision as unclear,
unenforceable, or inapplicable to activity that the Employee intends to engage
in, the Employee will first notify Company in writing and meet with a Company
representative and a neutral mediator (if the Company elects to retain one at
its expense) to discuss resolution of any disputes between the parties. The
Employee will provide this notification at least fourteen (14) days before the
Employee engages in any activity on behalf of a competing business or engages in
other activity that could foreseeably fall within a questioned restriction. The
failure to comply with this requirement shall waive the Employee's right to
challenge the reasonable scope, clarity, applicability, or enforceability of the
Agreement and its restrictions at a later time. All rights for both parties will
be preserved if the Early Resolution Conference requirement is complied with
even if no agreement is reached in the conference.

      5. Termination of Employment:

            a. The Employee is an employee at-will, and either the Employee or
the Company may terminate the employment relationship at any time for any reason
with or without Cause (as defined below). The date upon which the termination of
the Employee's employment becomes effective pursuant to this Agreement shall be
referred to herein as the "Termination Date." The Termination Date shall be the
date upon which any of the following events shall occur:

                  (i) the death of the Employee;

                  (ii) the Disability (as defined below) of the Employee;

                  (iii) the Company's delivery of a written notice to the
Employee of a termination of the Employee's employment for Cause (as defined
below);

                  (iv) the Company's delivery of a written notice to the
Employee of a termination of the Employee's employment Without Cause (as defined
below); or

                  (v) resignation by the Employee.

For purposes of this Agreement, the Employee's employment will not be deemed to
have terminated upon a Change in Control (as defined below).

            b. For purposes of this Agreement, the "Disability" of the Employee
shall mean the Employee's inability, because of mental or physical illness or
incapacity, whether total or partial, to perform one or more of the primary
duties of the Employee's employment with or without reasonable accommodation,
and which continues for a length of time that exceeds any

                                        8
<PAGE>

period of leave following which the Employee may have a right to be restored to
the same job or to an equivalent job under federal, state or local law.

            c. For purposes of this Agreement, the term "Cause" shall mean the
Employee's (i) conviction or entry of a plea of guilty or nolo contendere, with
respect to any felony; (ii) commission of any act of willful misconduct, gross
negligence, fraud or dishonesty; (iii) violation of any term of this Agreement
or any written policy of the Company; or (iv) inability to meet the performance
objectives for the respective position. Notwithstanding the foregoing, the
Company shall not make a determination of "Cause" in any case where the Cause is
reasonably curable, in which case the Company shall provide a reasonable
opportunity of not less than ten (10) business days for the Employee to cure
prior to such a determination. In addition, if termination is pursuant to
subsection (iv), a determination of Cause shall only be made after the Company
has undergone a performance management process with the Employee and the
Employee has not shown ability to perform satisfactorily after a period of not
less than thirty (30) days.

            d. For purposes of this Agreement, "Without Cause" shall mean for
any reason(s) whatsoever (other than the reasons described in Sections 5(a)(i),
5(a)(ii), 5(a)(iii), and 5(a)(v) hereof).

            e. The Employee should give the Company reasonable notice when
resigning from the Company. Reasonable notice being defined as two (2) months.

            f. For purposes of this Agreement, a "Change in Control" of the
Company means a sale, transfer or other disposition of all or substantially all
of the assets of the Company, or the consummation of a merger or consolidation
of the Company or a sale or exchange of capital stock of the Company, in either
case as a result of which the stockholders of the Company immediately prior to
such transaction own, in the aggregate, less than a majority of the outstanding
voting capital stock or equity interests of the surviving or resulting entity.

      6. Payments Upon Termination of Employment.

            a. Death or Disability. If the Employee's employment hereunder is
terminated due to the Employee's death or Disability pursuant to Sections
5(a)(i) or (ii) hereof, the Company shall pay or provide to the Employee, the
Employee's designated beneficiary or to the Employee's estate (i) all base
salary pursuant to Section 3(a) hereof and any vacation pay pursuant to Section
3(g) hereof, in each case which has been earned but unpaid as of the Termination
Date; and (ii) any benefits to which the Employee may be entitled under any
employee benefits plan, policy or arrangement pursuant to Section 3(b) hereof
(including, but not limited to, life insurance and disability insurance) in
which he/she is a participant in accordance with the written terms of such plan,
policy or arrangement up to and including the Termination Date.

            b. Termination for Cause or Resignation. If the Employee's
employment hereunder is terminated by the Company for Cause pursuant to Section
5(a)(iii) or due to the Employee's resignation pursuant to Section 5(a)(v), the
Company shall pay or provide to the

                                        9
<PAGE>

Employee (i) all base salary pursuant to Section 3(a) hereof and any vacation
pay pursuant to Section 3(g) hereof, in each case which has been earned but
unpaid as of the Termination Date; and (ii) any benefits to which the Employee
may be entitled under any employee benefits plan, policy or arrangement pursuant
to Section 3(b) hereof in which he/she is a participant in accordance with the
written terms of such plan, policy or arrangement up to and including the
Termination Date.

            c. Termination Without Cause. If the Employee's employment hereunder
is terminated by the Company Without Cause pursuant to Section 5(a)(iv), the
Company shall award the Employee severance pay. The severance pay benefit shall
be the continuation of the Employee's then current base pay for a period of six
(6) months.

Upon termination, the Employee may be eligible to reinstate health insurance
benefits pursuant to COBRA. If the Employee's employment hereunder is terminated
by the Company Without Cause pursuant to Section 5(a)(iv) and Employee is
eligible for and elects COBRA coverage, the Company will pay the Employee's
premiums for continuation of health benefits under COBRA for up to six (6)
months following the Termination Date.

In order to be eligible to receive any severance payment or medical benefits
pursuant to this paragraph 6, the Employee must sign, prior to receiving such
Severance Payment, a valid release and waiver of all claims against the Company
relating to the Employee's employment or the termination thereof, in a format to
be determined by the Company and must continue to comply with the provisions of
Section 4. No payment shall be made hereunder until at least eight (8) days
following the execution and delivery by the Employee of the valid release and
waiver.

            d. No Other Payments. Except as provided in this Section 6, the
Employee shall not be entitled to receive any other payments or benefits from
the Company due to the termination of the Employee's employment, including but
not limited to, any employee benefits under any of the Company's employee
benefits plans or arrangements (other than at the Employee's expense under the
Consolidated Omnibus Budget Reconciliation Act of 1985 or pursuant to the
written terms of any pension benefit plan in which the Employee is a participant
in which the Company may have in effect from time to time) or any right to
severance benefits.

      7. Termination of Prior Employment Agreement; Representations and Release.
The Employee acknowledges that he is currently a party to an employment
agreement with one of the Company's wholly owned subsidiaries, Predix
Pharmaceuticals Ltd., dated September 6, 2002 (the "Old Agreement"). The
Employee and the Company agree that the Old Agreement shall terminate effective
immediately upon the Effective Date of this Agreement. The Employee further
confirms and agrees, in consideration for the benefits provided herein, as
follows:

            a. He has received full and final payment of all monies and other
benefits that are due and owing under the Old Agreement;

            b. As of the Effective Date, all rights to payment or benefits of
any kind expire and become null and void. The Employee specifically hereby
releases any rights he may have had or may in the future have to bring a claim
for breach of the Old Agreement or for

                                       10
<PAGE>

failure of any kind by the Company, its subsidiaries, affiliates, or any of
their officers, directors, employees or agents, to make payments or provide
benefits to him pursuant to the Old Agreement. Nothing in this paragraph shall
be interpreted as limiting the Employee's right to bring a claim for a breach of
this Agreement by the Company; and

            c. The Employee acknowledges and agrees that the Predix US Share
Option Plan has been cancelled and agrees that he has no rights to any of the
equity which may have been due him pursuant to the Old Agreement.

      8. Deductions and Withholding. The Employee agrees that the Company shall
withhold from any and all compensation payable under this Agreement all federal,
state, local and/or other taxes which the Company determines are required to be
withheld under applicable statutes and/or regulations from time to time in
effect and all amounts required to be deducted in respect of the Employee's
coverage by and participation in applicable Employee benefit plans, policies or
arrangements.

      9. Entire Agreement. This Agreement embodies the entire agreement of the
parties with respect to the Employee's employment and supersedes any other prior
oral or written agreements between the Employee and the Company and its
affiliates. This Agreement may not be changed or terminated orally but only by
an agreement in writing signed by the parties hereto.

      10. Waiver. The waiver by the Company of a breach of any provision of this
Agreement by the Employee shall not operate or be construed as a waiver of any
subsequent breach by the Employee. The waiver by the Employee of a breach of any
provision of this Agreement by the Company shall not operate or be construed as
a waiver of any subsequent breach by the Company.

      11. Governing Law. This Agreement shall be governed by, and construed in
accordance with, the laws of the Commonwealth of Massachusetts, without regard
to the choice of law rules of any state or where the Employee is in fact
required to work.

      12. Jurisdiction. Any legal suit, action or proceeding against any party
hereto arising out of or relating to this Agreement shall be brought solely in
the courts of the Commonwealth of Massachusetts or of the United States of
America for the District of Massachusetts and each party hereto waives any
objection which it may now or hereafter have to the laying of venue of any such
suit, action or proceeding and each party hereto irrevocably submits to the
jurisdiction of any such court in any suit, action or proceeding.

      13. Assignability. The obligations of the Employee may not be delegated
and, except as expressly provided in Section 6(a) relating to the designation of
beneficiaries, the Employee may not, without the Company's written consent
thereto, assign, transfer, convey, pledge, encumber, hypothecate or otherwise
dispose of this Agreement or any interest therein. Any such attempted delegation
or disposition shall be null and void and without effect. The Company and the
Employee agree that this Agreement and all of the Company's rights and
obligations hereunder may be assigned or transferred by the Company to and may
be assumed by and become binding upon and may inure to the benefit of any
affiliate of or successor to the

                                       11
<PAGE>

Company. The term "successor" shall mean (with respect to the Company or any of
its subsidiaries) any other corporation or other business entity which, by
merger, consolidation, purchase of the assets, or otherwise, acquires all or a
material part of the assets of the Company. Any assignment by the Company of its
rights or obligations hereunder to any affiliate of or successor to the Company
shall not be a termination of employment for purposes of this Agreement.

      14. Severability. If any provision of this Agreement as applied to either
party or to any circumstances shall be adjudged by a court of competent
jurisdiction or arbitrator to be void or unenforceable, the same shall in no way
affect any other provision of this Agreement or the validity or enforceability
of this Agreement. If any court or arbitrator construes any of the provisions of
Section 4 hereof, or any part thereof, to be unreasonable because of the
duration of such provisions of the geographic or other scope thereof, such court
or arbitrator may reduce the duration or restrict the geographic or other scope
of such provision and enforce such provision as so reduced or restricted.

      15. Notices. All notices to the Employee hereunder shall be in writing and
shall be delivered personally, sent by overnight courier or sent by registered
or certified mail, return receipt requested, to:

                  Dr. Michael Kauffman
                  [ADDRESS]

All notices to the Company hereunder shall be in writing and shall be delivered
personally, sent by overnight courier or sent by registered or certified mail,
return receipt requested, to:

                  Predix Pharmaceuticals Holdings, Inc.
                  10 K Gill Street
                  Woburn, MA 01801
                  Attention: President and CEO

Either party may change the address to which notices shall be sent by sending
written notice of such change of address to the other party.

      16. Section Headings. The section headings contained in this Agreement are
for reference purposes only and shall not affect in any way the meaning or
interpretation of this Agreement.

      17. Counterparts. This Agreement may be executed in one or more
counterparts, each of which shall be deemed to be an original, but all of which
taken together shall constitute one and the same instrument.

      18. Voluntary Agreement. The Employee acknowledges that before entering
into this Agreement, the Employee has had the opportunity to consult with any
attorney or other advisor of his/her choice, and that this Section 18 of this
Agreement constitutes advice from the Company to do so if he/she chooses. The
Employee further acknowledges that he/she has read

                                       12
<PAGE>

and understands this Agreement and has entered into this Agreement of his/her
own free will, and that no promises or representations have been made to him/her
by any person to induce him/her to enter into this Agreement other than the
express terms set forth herein.

      IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
as of the date first above written.

PREDIX PHARMACEUTICALS HOLDINGS, INC.       EMPLOYEE

By: /s/ NIK HAYES                           /s/ MICHAEL G. KAUFFMAN, MD
    -----------------                       ---------------------------
    Nik Hayes                               Employee signature
    Chief Operating Officer

                                            Michael Kauffman, MD
                                            ---------------------------
                                            Print Employee's Name

                                       13

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