Document:

Amendment No. 1 to the Genentech, Inc. Tax Reduction Investment Plan, as amended
      and restated

    
      EXHIBIT
        10.2

      

      

      AMENDMENT
        NO. 1 TO THE

      GENENTECH,
        INC. TAX REDUCTION INVESTMENT PLAN

      (January
        1, 2006 Restatement)

       

      GENENTECH,
        INC. (the “Company”), having established the Genentech, Inc. Tax Reduction
        Investment Plan (the “Plan”) effective as of January 1, 1985 and amended and
        restated the Plan in its entirety effective (most recently) as of January
        1,
        2006 (and the other dates specified therein), hereby amends the restated
        Plan as
        follows, effective as of October 1, 2006, except as otherwise provided
        below:

       

      1.    Section
        1.20 is amended in its entirety, to read as follows:

       

      “1.20
        Entry
        Date.
        “Entry
        Date” shall mean each calendar day in each Plan Year.”

       

      2.    Section
        2.3.1 is amended in its entirety, to read as follows:

       

      “2.3.1
        Active
        Participation.
        An Employee who has become a Participant under Section 2.1 may elect to become
        an Active Participant as of any Entry Date following the Employee’s receipt of
        his or her first pay check from the Employer, provided
        that he or she is then an Eligible Employee, and provided
        further,
        that he or she enrolls in the Plan and elects to make Salary Deferrals and/or
        Catch-Up Contributions, in such manner as the Committee (in its discretion)
        shall specify, in accordance with Section 3.
        Such Employee’s status as an Active Participant shall be effective as soon as
        administratively feasible following his or her enrollment.”

       

      3.    Section
        2.8 is amended in its entirety, to read as follows:

       

      “2.8
        Acquisitions.
        If determined by the Committee (in its discretion), an Acquired Employee
        may
        elect to become an Active Participant sooner than the date specified in Section
        2.3.1. As determined in the discretion of the Committee, such date shall
        be as
        soon as administratively 

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      feasible
        on or after the later of (a) the date on which the Acquired Employee becomes
        an
        Eligible Employee, or (b) such other date as may be specified by the Committee
        (which shall in no event be later than the Entry Date following the Acquired
        Employee’s receipt of his or her first pay check from the Employer). For
        purposes of this Section 2.8, an “Acquired Employee” is an Eligible Employee who
        becomes an Employee by reason of the acquisition by the Company or its Affiliate
        of the assets and liabilities of, or the voting stock of, another corporation
        or
        other business entity, or another type of business transaction effected by
        the
        Company or its Affiliate.”

       

      4.    Paragraph
        (a) of Section 3.2, Catch-Up
        Contributions,
        shall be amended in its entirety, to read as follows:

       

      “(a)    
         Eligible
        Participants.
        All Employees who are Participants eligible to make Salary Deferrals under
        this
        Plan and who have attained age fifty (50) before the close of the Plan Year
        shall be eligible to make “catch-up contributions” for the Plan Year in
        accordance with, and subject to the limitations of, Section 414(v) of the
        Code.
        An Active Participant who meets the foregoing requirements may elect to defer
        a
        portion of each payment of Compensation that would otherwise be made to him
        or
        her, after the election becomes and while it remains effective, equal to
        any
        whole percentage from 1% to 75% (inclusive) of such payment.”

      

       

      5.    Section
        3.3.1 is hereby amended in its entirety, to read as follows:

       

      “3.3.1 Amounts.
        Notwithstanding anything in Section 3.1.1 or 3.2 to the contrary, no Active
        Participant may elect to defer an amount of his or her Compensation for any
        pay
        period as Salary Deferrals and Catch-Up Contributions that, when combined,
        exceeds 75% of each payment of Compensation. The amount of Salary Deferrals
        or
        Catch-Up Contributions that may be made by each Active Participant for each
        payroll period shall be the amount in dollars and cents that is nearest to
        the
        amount of Compensation subject to the deferral election multiplied by the
        percentage elected by the Participant pursuant to Section 3.1.1 or 3.2, as
        applicable.”

       

      6.    Section
        4.1.1 is hereby amended in its entirety, to read as follows:

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

       

      “4.1.1 Basic
        Matching Contributions.
        Effective as of October 1, 2006, the Employer will make Matching Contributions
        for each eligible Active Participant on a payroll by payroll basis equal
        to 100%
        of the eligible Active Participant’s Salary Deferrals for the pay period, but
        not to exceed 5% of the eligible Active Participant’s Compensation per pay check
        for the pay period against which Salary Deferrals are made.”

       

      7.    Section
        4.1.2 is hereby amended in its entirety, to read as follows:

       

      “4.1.2 True-Up
        Matching Contributions. 

      (a)    
         True-Up
        for Quarter Ending September 30, 2006.
        In addition to the Matching Contributions set forth in Section 4.1.1, the
        Employer will make additional Matching Contributions for the 2006 Plan Year,
        to
        be allocated as of September 29, 2006 (the Valuation Date immediately preceding
        the last day of the calendar quarter ending September 30, 2006) to eligible
        Active Participants as an adjustment to take into account any changes in
        Compensation or Participant Salary Deferral elections which may have occurred
        during the period from January 1, 2006 through September 29, 2006. The amount
        of
        the additional Matching Contributions for each eligible Active Participant
        shall
        be equal to the difference, if any, between (i) the Matching Contributions
        allocated to the eligible Active Participant pursuant to Section 4.1.1 for
        the
        period from January 1, 2006 through September 29, 2006, and (ii) a Matching
        Contribution equal to 100% of the eligible Active Participant’s Salary Deferrals
        but not to exceed 5% of the eligible Active Participant’s Compensation for the
        period from January 1, 2006 through September 29, 2006. Notwithstanding
        the foregoing, the only Compensation that shall be taken into account for
        purposes of this additional Matching Contribution shall be Compensation paid
        (or
        payable if deferred under Section 3) to the eligible Active Participant for
        payroll periods for which he or she made Salary Deferrals or after which
        the
Active
        Participant’s Section
        401(k) Ceiling took effect. In
        order to be eligible for this additional Matching Contribution, a Participant
        must be an Eligible Employee on September 29, 2006, or his or her employment
        with the Employer must have been terminated during the period from January
        1,
        2006 through September 29, 2006 due to Disability or death.

       

      (b)    
         2006
        Year-End True-Up.
        In addition to the Matching Contributions set forth in Sections 4.1.1 and
        4.1.2(a), the Employers will make additional Matching Contributions for the
        2006
        Plan Year, to be allocated as of December 29, 2006 (the last Valuation Date
        in
        the 2006 Plan Year) to eligible Active Participants as an adjustment to take
        into account any changes in Compensation or Participant Salary Deferral
        elections which may have occurred during the period from October 1, 2006
        through
        December 29, 2006. The amount of the additional Matching Contributions for
        each
        eligible Active Participant shall be equal to the difference, if any, between
        (i) the Matching Contributions allocated to the eligible Active Participant
        pursuant to Sections 4.1.1 and 4.1.2(a) for the Plan Year, and (ii) a Matching
        Contribution equal to 100% of the eligible Active Participant’s Salary Deferrals
        for the Plan Year but not to exceed 5% of the eligible Active Participant’s
        Compensation for the Plan Year. Notwithstanding the foregoing, the only

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      Compensation
        that shall be taken into account for purposes of this additional Matching
        Contribution shall be Compensation paid (or payable if deferred under Section
        3)
        to the eligible Active Participant for payroll periods for which he or she
        made
        Salary Deferrals or after which the Active Participant’s Section 401(k) Ceiling
        took effect. In order to be eligible for this additional Matching Contribution,
        a Participant must be an Eligible Employee on December 29, 2006, or his or
        her
        employment with the Employer must have been terminated during the Plan Year
        due
        to Disability or death.

       

      (c)    
         True-Up
        for Plan Years Beginning January 1, 2007 and After.
        In addition to the Matching Contributions set forth in Section 4.1.1, the
        Employers will make additional Matching Contributions for the Plan Year,
        to be
        allocated as of the last Valuation Date of the Plan Year to eligible Active
        Participants as an adjustment to take into account any changes in Compensation
        or Participant Salary Deferral elections which may have occurred during the
        Plan
        Year. The amount of the additional Matching Contributions for each eligible
        Active Participant shall be equal to the difference, if any, between (i)
        the
        Matching Contributions allocated to the eligible Active Participant pursuant
        to
        Section 4.1.1 for the Plan Year, and (ii) a Matching Contribution equal to
        100%
        of the eligible Active Participant’s Salary Deferrals for the Plan Year but not
        to exceed 5% of the eligible Active Participant’s Compensation for the Plan
        Year. Notwithstanding the foregoing, the only Compensation that shall be
        taken
        into account for purposes of this additional Matching Contribution shall
        be
        Compensation paid (or payable if deferred under Section 3) to the eligible
        Active Participant for payroll periods for which he or she made Salary Deferrals
        or after which the Active Participant’s Section 401(k) Ceiling took effect. In
        order to be eligible for this additional Employer Matching Contribution,
        a
        Participant must be an Eligible Employee on the last Valuation Date of the
        Plan
        Year, or his or her employment with the Employer must have been terminated
        during the Plan Year due to Disability or death.”

       

      8.    The
        following Section 6.8 is added to the Plan:

       

      “6.8 Forfeitures.
        Any amounts attributable to forfeitures transferred pursuant to the merger
        of
        another tax-qualified plan with this Plan, and any other amounts to be treated
        as forfeitures under the Plan, shall be applied, at the Committee’s election and
        in its discretion, to: (a) reduce the Employer’s obligation to make Matching
        Contributions; (b) reduce the Employer’s obligation to make Nonelective
        Contributions; (c) fund any other Employer contributions (e.g., Qualified
        Nonelective Contributions) determined by the Committee to be necessary or
        appropriate; and/or (d) pay administrative expenses under the Plan in accordance
        with Section 9.9.”

       

      9.    The
        following paragraph (e) is added to Section 7.4.5, effective as of January
        1,
        2007:

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

       

      “(e)
        Subject
        to the other requirements of this Section 7.4.5 and the Plan, beginning January
        1, 2007, a distribution in the form of an Eligible Rollover Distribution
        to a
        Beneficiary who is not the surviving spouse of the Participant may be directly
        rolled over to an IRA in the name of the Beneficiary.”

       

      10.    Section
        8.2.3 is hereby amended in its entirety, to read as follows:

       

      “8.2.3
        Mandatory Suspension and Contribution Limitations.
        If determined by the Committee to be necessary or appropriate in order to
        preserve the tax-qualification of the Plan, no withdrawal shall be made under
        this Section 8.2 unless the Participant irrevocably agrees, evidenced in
        such
        manner as the Committee (in its discretion) may specify, in his or her hardship
        withdrawal application that the Participant shall not make contributions
        to,
        compensation deferrals under or payments in connection with the exercise
        of any
        rights granted under this Plan or any other qualified plan or any nonqualified
        stock option, stock purchase, deferred compensation or similar plan (but
        not any
        health or welfare plan) maintained by any Employer or Affiliate for a period
        of
        six (6) months following receipt of the withdrawal. The Participant may elect
        to
        resume his or her active participation in the Plan as of any Entry Date
        following the end of the suspension period described above, provided that
        he or
        she elects to become an Active Participant in accordance with Section
        2.3.1.”

       

      11.    The
        following Section 8.6 is added to the Plan:

       

      “8.6 Qualified
        Reservist Distribution. Notwithstanding
        anything in the Plan to the contrary, a Participant who is a reservist or
        national guardsman (as defined in 37 U.S. Code 101(24)) and who is ordered
        or
        called to active duty after September 11, 2001 and before December 31,
        2007 

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

       

      for
        a period in excess of one hundred seventy-nine (179) days or for an indefinite
        period, may request a withdrawal from his or her Salary Deferral
        Account.”

       

      IN
        WITNESS WHEREOF,
        the Company, by its duly authorized officers, has executed this Amendment
        No. 1
        to the restated Plan, on the date(s) indicated below.

      

      
        	 	
                GENENTECH,
                  INC.

              	 
	 	
                By:

              	
                /s/ DAVID
                  A. EBERSMAN

              	 
	 	
                Title:

              	
                Executive
                  Vice President and Chief Financial Officer

              	 
	 	
                Date:

              	
                December
                  4, 2006

              	 
	 	 	 	 
	 	
                And
                  by:

              	
                /s/ WILLIAM
                  ANDERSON

              	 
	 	
                Title:

              	
                Vice
                  President, Sales and Marketing

              	 
	 	
                Date:

              	
                December
                  4, 2006Amendment No. 2 to the Genentech, Inc. Tax Reduction Investment Plan, as amended
      and restated

    
      EXHIBIT
        10.3

      

      

      AMENDMENT
        NO. 2 TO THE

      GENENTECH,
        INC. TAX REDUCTION INVESTMENT PLAN

      (January
        1, 2006 Restatement)

       

      GENENTECH,
        INC. (the “Company”), having established the Genentech, Inc. Tax Reduction
        Investment Plan (the “Plan”) effective as of January 1, 1985, amended and
        restated the Plan in its entirety effective (most recently) as of January
        1,
        2006 (and the other dates specified therein), and subsequently amended by
        Amendment No. 1 thereto, hereby further amends the restated Plan as
        follows:

       

      1.    Section
        1.14 is amended in its entirety, effective as of January 1, 2007, to read
        as
        follows:

       

      “1.14
        Eligible
        Bonus.
        “Eligible
        Bonus” means any of the following payments paid by the Employer to an Employee:
        (a) any
        annual cash bonus under the Company’s Corporate Bonus Program, (b) any
        fourth calendar quarter commission payment under the Company’s Field Sales
        Incentive Compensation Plan; and/or (c)
        any bonus paid by the Company and designated as an incremental sales bonus.
        Notwithstanding the foregoing, all Eligible Bonus amounts shall be determined
        net of employee stock purchase plan and mandatory deductions including, without
        limitation, Employee-paid FICA and SDI withholdings.”

       

      
        	
                2.

              	
                Section
                  6.3.5 is amended in its entirety, effective as of March 31, 2007,
                  to read
                  as follows:

              

      

       

      “6.3.5
        Limitation
        on Investment in Company Stock Fund.
        Effective as of March 31, 2007, and notwithstanding anything in the Plan
        to the
        contrary, the following restrictions on investment in the Company Stock Fund
        shall apply:

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      (1)    Investment
        of future contributions (Salary Deferrals, Matching Contributions, Nonelective
        Contributions and Rollovers) in the Company Stock Fund shall be limited to
        30%
        of new money invested;

      (2)    Exchanges
        of existing assets into the Company Stock Fund will be limited to 30% of
        the
        Participant’s total Plan account at the time of the exchange; and

      (3)    Existing
        investments in the Company Stock Fund may be sold at any time (subject to
        any
        applicable trading restrictions) but once sold, reinvestment in the Company
        Stock Fund is limited to the above restrictions.”

       

      IN
        WITNESS WHEREOF,
        the Company, by its duly authorized officers, has executed this Amendment
        No. 2
        to the restated Plan, on the date(s) indicated below.

       

      
        	
                GENENTECH,
                  INC.

              
	 	 	 	 	 
	
                By:

              	
                /s/ DAVID
                  A. EBERSMAN

              	 	
                And
                  by:

              	
                /s/ DENISE
                  SMITH-HAMS

              
	
                Title:

              	
                   Chief
                  Financial Officer

              	 	
                Title:

              	
                   Vice
                  President, Human Resources

              
	
                Dated:

              	
                   March
                  2, 2007

              	 	
                Dated:

              	
                   March
                  2, 2007

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