Document:

Exhibit
        10.1

      AGREEMENT
        AND GENERAL RELEASE

      

      Workstream,
        Inc. (“Employer”) and Philip L Oreste, his heirs, executors, administrators,
        successors, and assigns (collectively referred to throughout this Agreement
        as
“Employee”), agree that:

      

      
        	 	
                1.

              	
                Last
                  Day of Employment.
                  Employee’s last day of active employment with Employer was February 15,
                  2008.

              

      

      

      
        	 	
                2.

              	
                Consideration.
                  In
                  consideration for signing this Agreement, complying with its terms,
                  and
                  not revoking this Agreement during the revocation period set forth
                  below,
                  Employer agrees to pay to Employee:

              

      

      

      
        	 	
                ·

              	
                The
                  equivalent of three months salary, sixty two thousand and five
                  hundred
                  dollars ($62,500.00) as follows: Workstream will issue (3) monthly
                  checks
                  in the amount of Twenty Thousand Eight Hundred Thirty Three Dollars
                  and 33
                  cents ($20,833.33) per check. The first check will be issued no
                  later than
                  the first day of the first month following the later of (i) Employer’s
                  receipt of a signed original of this Agreement, or (ii) the expiration
                  of
                  the Revocation Period referenced below without Employee having
                  revoked
                  this Agreement during the Revocation Period, and each subsequent
                  check
                  will be issued no later than the first day of the month for the
                  next three
                  months. Workstream shall issue an IRS form 1099 at the end of the
                  year to
                  Phil Oreste. Workstream makes no representation as to the taxability
                  of
                  the amounts paid to Phil Oreste. Phil Oreste agrees to pay federal
                  or
                  state taxes, if any, which are required by law to be paid with
                  respect to
                  this amount. Moreover, Phil Oreste agrees to indemnify Workstream
                  and hold
                  it harmless from any interest, taxes or penalties assessed against
                  it by
                  any governmental agency as a result of the non-payment of taxes
                  on any
                  amounts paid to and legally due by Phil Oreste under the terms
                  of this
                  Agreement;

              

      

      

      
        	 	
                ·

              	
                30,
                  000 Restricted Stock Units which will be 100% vested upon signature
                  of
                  these conditions;

              

      

      

      
        	 	
                ·

              	
                Workstream
                  agrees to pay health insurance coverage for Phil Oreste ’s family through
                  December 31, 2008;

              

      

      

      
        	 	
                ·

              	
                Outstanding
                  travel and expense reimbursement in accordance with the Workstream
                  travel
                  policy provided the expenses are submitted for processing no later
                  than 30
                  days from the date of this
                  agreement;

              

      

      

      
        	 	
                ·

              	
                Outplacement
                  assistance premium package through Allen and
                  Associates;

              

      

      

      
        	 	
                ·

              	
                Membership
                  to 6FigureJobs.com for 12 months;
                  and

              

      

      

      
        	 	
                ·

              	
                Workstream
                  waives its right to enforce any non-competition provisions of any
                  agreements between Workstream and Phil
                  Oreste.

              

      

      

      
        	 	
                3.

              	
                No
                  Consideration Absent Execution of this Agreement.
                  Employee
                  understands and agrees that Employee would not receive the monies
                  and/or
                  benefits specified in paragraph “2” above, except for Employee’s execution
                  of this Agreement, his fulfillment of the promises contained herein,
                  and
                  the expiration of the revocation period without Employee revoking
                  this
                  Agreement. 

              

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      

      

      
        	 	
                4.

              	
                General
                  Release of All Claims.
                  Employee
                  knowingly and voluntarily releases and forever discharges Employer,
                  its
                  parent corporation, affiliates, subsidiaries, divisions, predecessors,
                  insurers, successors and assigns, and their current and former
                  employees,
                  attorneys, officers, directors and agents thereof, both individually
                  and
                  in their business capacities, and their employee benefit plans
                  and
                  programs and their administrators and fiduciaries (collectively
                  referred
                  to throughout the remainder of this Agreement as “Releasees”), of and from
                  any and all claims, known and unknown, asserted or unasserted,
                  which the
                  Employee has or may have against Releasees as of the date of execution
                  of
                  this Agreement and General Release, including, but not limited
                  to, any
                  alleged violation of: 

              

      

      

      
        	 	
                ·

              	
                The
                  National Labor Relations Act; 

              

      

      
        	 	
                ·

              	
                Title
                  VII of the Civil Rights Act;

              

      

      
        	 	
                ·

              	
                Sections
                  1981 through 1988 of Title 42 of the United States
                  Code;

              

      

      
        	 	
                ·

              	
                The
                  Employee Retirement Income Security Act (except for any vested
                  benefits
                  under any tax qualified benefit
                  plan);

              

      

      
        	 	
                ·

              	
                The
                  Immigration Reform and Control Act;

              

      

      
        	 	
                ·

              	
                The
                  Americans with Disabilities Act;

              

      

      
        	 	
                ·

              	
                The
                  Age Discrimination in Employment
                  Act;

              

      

      
        	 	
                ·

              	
                The
                  Occupational Safety and Health Act;

              

      

      
        	 	
                ·

              	
                The
                  Workers Adjustment and Retraining Notification
                  Act;

              

      

      
        	 	
                ·

              	
                The
                  Fair Credit Reporting Act; 

              

      

      
        	 	
                ·

              	
                The
                  Uniformed Services Employment and Reemployment Rights
                  Act;

              

      

      
        	 	
                ·

              	
                Worker
                  Adjustment and Retraining Notification
                  Act;

              

      

      
        	 	
                ·

              	
                Employee
                  Polygraph Protection Act;

              

      

      
        	 	
                ·

              	
                The
                  employee (whistleblower) civil protection provisions of the Corporate
                  and
                  Criminal Fraud Accountability Act (Sarbanes-Oxley
                  Act);

              

      

      
        	 	
                ·

              	
                California
                  Fair Employment and Housing Act - Cal. Gov’t Code § 12900 et
                  seq.;

              

      

      
        	 	
                ·

              	
                Statutory
                  Provision Regarding Retaliation/Discrimination for Filing a Workers
                  Compensation Claim - Cal. Lab. Code §132a (1) to
                  (4);

              

      

      
        	 	
                ·

              	
                California
                  Unruh Civil Rights Act - Civ. Code § 51 et
                  seq.;

              

      

      
        	 	
                ·

              	
                California
                  Sexual Orientation Bias Law - Cal. Lab. Code §1101 et
                  seq.;

              

      

      
        	 	
                ·

              	
                California
                  AIDS Testing and Confidentiality Law - Cal. Health & Safety Code
                  §199.20 et seq.;

              

      

      
        	 	
                ·

              	
                California
                  Confidentiality of Medical Information - Cal. Civ. Code §56 et
                  seq.;

              

      

      
        	 	
                ·

              	
                California
                  Smokers’ Rights Law - Cal. Lab. Code
§96;

              

      

      
        	 	
                ·

              	
                California
                  Parental Leave Law - Cal. Lab. Code §230.7 et
                  seq.;

              

      

      
        	 	
                ·

              	
                California
                  Apprenticeship Program Bias Law - Cal. Lab. Code §3070 et seq.;
                  

              

      

      
        	 	
                ·

              	
                California
                  Equal Pay Law - Cal. Lab. Code §1197.5 et seq.;

              

      

      
        	 	
                ·

              	
                California
                  Whistleblower Protection Law - Cal. Lab. Code § 1102-5(a) to (c);
                  

              

      

      
        	 	
                ·

              	
                California
                  Military Personnel Bias Law - Cal. Mil. & Vet. Code §394 et seq.;
                  

              

      

      
        	 	
                ·

              	
                California
                  Family Rights Act Leave - Cal. Gov’t Code
                  §12945;

              

      

      
        	 	
                ·

              	
                California
                  Kin Care Leave - Cal.Lab.Code §233;

              

      

      
        	 	
                ·

              	
                California
                  Parental Leave for School Visits Law - Cal. Lab. Code §230.7 et seq.;
                  

              

      

      
        	 	
                ·

              	
                California
                  Electronic Monitoring of Employees - Cal. Lab. Code §435 et
                  seq.;

              

      

      
        	 	
                ·

              	
                Cal/OSHA
                  law, as amended;

              

      

      
        	 	
                ·

              	
                California
                  Consumer Reports: Discrimination Law - Cal. Civ. Code §1786.10 et
                  seq.;

              

      

      
        	 	
                ·

              	
                California
                  Political Activities of Employees Act - Cal. Lab. Code §1101 et seq.;
                  

              

      

      
        	 	
                ·

              	
                California
                  Domestic Violence Victim Employment Leave Act - Cal. Lab. Code
§230.1;
                  

              

      

      
        	 	
                ·

              	
                California
                  Voting Leave Law - Cal. Elec. Code §14350 et seq.;
                  

              

      

      
        	 	
                ·

              	
                California
                  Court Leave Law - Cal. Lab. Code
§230;

              

      

      
        	 	
                ·

              	
                any
                  other federal, state or local law, rule, regulation, or ordinance;
                  

              

      

      
        	 	
                ·

              	
                any
                  public policy, contract, tort, or common law;
                  or

              

      

      
        	 	
                ·

              	
                any
                  basis for recovering costs, fees, or other expenses including attorneys’
                  fees incurred in these matters.

              

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      

       

      
        	 	
                .1

              	
                To
                  achieve a full and complete release as described in herein, Employee
                  expressly waives and relinquishes all rights and benefits afforded
                  Employee by Section 1542 of the Civil Code of the State of California,
                  and
                  Employee does so understanding and acknowledging the significance
                  and
                  consequence of such specific waiver of section 1542. Section 1542
                  of the
                  Civil Code of the State of California states as
                  follows:

              

      

      

      A
        GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW
        OR
        SUSPECT TO EXIST IN HER OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE,
        WHICH
        IF KNOWN BY HIM OR HER MUST HAVE MATERIALLY AFFECTED HER OR HER SETTLEMENT
        WITH
        THE DEBTOR.

      

      Thus,
        notwithstanding the provisions of section 1542, and for the purpose of
        implementing a full and complete release and discharge of Releasees, Employee
        expressly acknowledges this Agreement is intended to include in its effect,
        without limitation, all claims not known or suspected to exist in Employee’s
        favor at the time of signing this Agreement.

      

      
        	 	
                .2

              	
                Employee
                  agrees and understands this is a full and final release covering
                  all known
                  and unknown and anticipated and unanticipated injuries, debts,
                  claims, or
                  damages which may have arisen, or which may arise, connected with
                  all
                  matters from the beginning of time to the date hereof, including
                  but not
                  limited to those injuries, debts, claims, or damages now known
                  or
                  disclosed which may have arisen, or which may arise, from Employee’s
                  employment with MSN and/or InteliStaf as described above. This
                  Agreement
                  does not extend to those rights which as a matter of law cannot
                  be waived,
                  including but not limited to unwaivable rights Employee may have
                  under the
                  California Labor Code such as rights to reimbursement or indemnity
                  under
                  Labor Code § 2802, nor does this Agreement affect any right Employee may
                  have to receive workers’ compensation benefits, unemployment benefits
                  pursuant to the California Unemployment Insurance Code or State
                  Disability
                  insurance benefits. 

              

      

      

      
        	 	
                5.

              	
                Acknowledgments
                  and Affirmations.

              

      

      

      Employee
        affirms that Employee has not filed, caused to be filed, or presently is
        a party
        to any claim against Employer.

      

      
        	 	
                .1

              	
                Employee
                  also affirms that Employee has been paid and/or has received all
                  compensation, wages, and/or benefits to which Employee may be entitled,
                  including accrued but unused vacation time through February 15,
                  2008 in
                  the amount of eight thousand six hundred sixty one dollars and
                  forty one
                  cents ($8661.41), representing 80.07 hours of vacation time, and
                  unused
                  flex time in the amount of one thousand seven hundred thirty dollars
                  and
                  seventy seven cents ($1730.77), representing sixteen (16) hours
                  of flex
                  time. Employee affirms that he waives all rights to any and all
                  commissions and bonuses stipulated in any employment agreement
                  or
                  commission plan between Workstream and Employee. The agreed termination
                  date is February 15, 2008, therefore Workstream is providing the
                  difference between the final checks sent to Phil Oreste on February
                  15th
                  2008 and the effective termination date of February 15th, 2008.
                  An
                  additional 16 hours of wages in the amount of $1730.77 as well
                  as an
                  additional 4.62 hours of accrued time equating to $499.76 will
                  be paid by
                  Workstream with a check totaling $2230.53 included with is agreement
                  via
                  FedEx Delivery.

              

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      

      

      
        	 	
                .2

              	
                Employee
                  affirms that Employee has been granted any leave to which Employee
                  was
                  entitled under the Family and Medical Leave Act or related state
                  or local
                  leave or disability accommodation laws and has not been subjected
                  to
                  retaliation for taking such leave.

              

      

      

      
        	 	
                .3

              	
                Employee
                  further affirms that Employee has no known workplace injuries or
                  occupational diseases. Employee also affirms that Employee has
                  not
                  divulged any proprietary or confidential information of Employer
                  and will
                  continue to maintain the confidentiality of such information consistent
                  with Employer’s policies and common law.

              

      

      

      
        	 	
                .4

              	
                Employee
                  further affirms that Employee has not been retaliated against for
                  reporting any allegations of wrongdoing by Employer or its officers,
                  including any allegations of corporate fraud. Both Parties acknowledge
                  that this Agreement does not limit either party’s right, where applicable,
                  to file or participate in an investigative proceeding of any federal,
                  state or local governmental agency. To the extent permitted by
                  law,
                  Employee agrees that if such an administrative claim is made, Employee
                  shall not be entitled to recover any individual monetary relief
                  or other
                  individual remedies.

              

      

      

      
        	 	
                6.

              	
                Confidentiality
                  and Return of Property. Employee
                  agrees not to disclose any information regarding the underlying
                  facts
                  leading up to or the existence or substance of this Agreement and
                  General
                  Release, except to Employee’s spouse, tax advisor, and/or an attorney with
                  whom Employee chooses to consult regarding Employee’s consideration of
                  this Agreement and General Release.

              

      

      

      
        	 	
                .1

              	
                Employee
                  affirms that Employee has returned all of Employer’s property, documents,
                  and/or any confidential information in Employee’s possession or control.
                  Employee also affirms that Employee is in possession of all of
                  Employee’s
                  property that Employee had at Employer’s premises and that Employer is not
                  in possession of any of Employee’s
                  property.

              

      

      

      
        	 	
                7.

              	
                Governing
                  Law and Interpretation.
                  This Agreement and General Release shall be governed and conformed
                  in
                  accordance with the laws of the state in which Employee last worked
                  for
                  Employer, without regard to that state’s conflict of laws provision. In
                  the event of a breach of any provision of this Agreement and General
                  Release, either party may institute an action specifically to enforce
                  any
                  term or terms of this Agreement and General Release and/or seek
                  any
                  damages for breach. Should any provision of this Agreement and
                  General
                  Release be declared illegal or unenforceable by any court of competent
                  jurisdiction and cannot be modified to be enforceable, excluding
                  the
                  general release language, such provision shall immediately become
                  null and
                  void, leaving the remainder of this Agreement and General Release
                  in full
                  force and effect.

              

      

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      

      

      
        	 	
                8.

              	
                Nonadmission
                  of Wrongdoing.
                  The Parties agree that neither this Agreement and General Release
                  nor the
                  furnishing of the consideration for this Agreement and General
                  Release
                  shall be deemed or construed at any time for any purpose as an
                  admission
                  by Releasees of wrongdoing or evidence of any liability or unlawful
                  conduct of any kind.

              

      

       

      
        	 	
                9.

              	
                Amendment.
                  This Agreement and General Release may not be modified, altered
                  or changed
                  except in writing and signed by both Parties wherein specific reference
                  is
                  made to this Agreement and General
                  Release.

              

      

      

      
        	 	
                10.

              	
                Entire
                  Agreement.
                  This Agreement and General Release sets forth the entire agreement
                  between
                  the Parties hereto, and fully supersedes any prior agreements or
                  understandings between the Parties. Employee acknowledges that
                  Employee
                  has not relied on any representations, promises, or agreements
                  of any kind
                  made to Employee in connection with Employee’s decision to accept this
                  Agreement and General Release, except for those set forth in this
                  Agreement and General Release.

              

      

      

       

      EMPLOYEE
        IS ADVISED THAT EMPLOYEE HAS UP TO TWENTY-ONE (21) CALENDAR DAYS TO CONSIDER
        THIS AGREEMENT AND GENERAL RELEASE. EMPLOYEE ALSO IS ADVISED TO CONSULT WITH
        AN
        ATTORNEY PRIOR TO EMPLOYEE’S SIGNING OF THIS AGREEMENT AND GENERAL
        RELEASE.

      

      EMPLOYEE
        MAY REVOKE THIS AGREEMENT AND GENERAL RELEASE FOR A PERIOD OF SEVEN (7) CALENDAR
        DAYS FOLLOWING THE DAY EMPLOYEE SIGNS THIS AGREEMENT AND GENERAL RELEASE.
        ANY
        REVOCATION WITHIN THIS PERIOD MUST BE SUBMITTED, IN WRITING, TO GINGER
        SIMPSON,
        DIRECTOR OF HUMAN RESOURCES, WORKSTREAM, INC., 2600 LAKE LUCIEN DRIVE #410,
        MAITLAND, FL 32751, AND
        STATE, “I HEREBY REVOKE MY ACCEPTANCE OF OUR AGREEMENT AND GENERAL RELEASE.” THE
        REVOCATION MUST BE PERSONALLY DELIVERED TO GINGER SIMPSON OR MAILED TO GINGER
        SIMPSON AT THE ADDRESS LISTED ABOVE AND POSTMARKED WITHIN SEVEN (7) CALENDAR
        DAYS AFTER EMPLOYEE SIGNS THIS AGREEMENT AND GENERAL RELEASE.

      

      EMPLOYEE
        AGREES THAT ANY MODIFICATIONS, MATERIAL OR OTHISWISE, MADE TO THIS AGREEMENT
        AND
        GENERAL RELEASE, DO NOT RESTART OR AFFECT IN ANY MANNER THE ORIGINAL UP TO
        TWENTY-ONE (21) CALENDAR DAY CONSIDERATION PERIOD. 

      

      EMPLOYEE
        FREELY AND KNOWINGLY, AND AFTER DUE CONSIDERATION, ENTERS INTO THIS AGREEMENT
        AND GENERAL RELEASE INTENDING TO WAIVE, SETTLE AND RELEASE ALL CLAIMS EMPLOYEE
        HAS OR MIGHT HAVE AGAINST RELEASEES.

      
        
           

        

        
           

          
            

          

        

        
           

        

      

      The
        Parties knowingly and voluntarily sign this Agreement and General Release
        as of
        the date(s) set forth below:

      
        	 	 	
                WORKSTREAM,
                  INC.

              
	 	 	     
	 	
                By:

              	    

	
                 

              	 	     
	
                By:____________________________________

              	
                Ginger
                  Simpson

              
	
                Philip
                  L. Oreste

              	
                Director
                  of Human Resources

              
	 	 	 
	
                Date:
                  __________________________________

              	
                Date:Exhibit
      10.6

     

    EMPLOYMENT
      AGREEMENT

     

    AGREEMENT
      (the “Agreement”),
      dated
      as of January
      8, 2008, by and between ZIOPHARM Oncology, Inc., a Delaware corporation with
      principal executive offices at 1180 Avenue of the Americas, New York, NY 10036
      (the “Company”),
      and
      JONATHAN J. LEWIS, M.D., Ph.D., residing at 1522 Fairfield Beach Road,
      Fairfield, CT 06824 (the “Executive”).

     

    W
      I T N E S S E T H:

     

    WHEREAS,
      the Company desires to employ the Executive as Chief Executive Officer of the
      Company, and the Executive desires to serve the Company in that capacity, upon
      the terms and subject to the conditions contained in this
      Agreement;

     

    NOW,
      THEREFORE, in consideration of the mutual covenants and agreements herein
      contained, the parties hereto hereby agree as follows:

     

    1. Employment.

     

    (a) Services.
      During the Term (as hereinafter defined), the Executive will be employed by
      the
      Company as its Chief Executive Officer. The Executive will report directly
      to
      the Board of Directors of the Company (the "Board") and shall perform such
      duties assigned by the Board as are consistent with his position as Chief
      Executive Officer (the “Services”). The Executive agrees to perform such duties
      faithfully, to use his best efforts to advance the best interests of the
      Company, to devote substantially all of his business time, attention and
      energies to the business of the Company, and while he remains employed, not
      to
      engage in any other business activity, whether or not such business activity
      is
      pursued for gain, profit or other pecuniary advantage, that will interfere
      with
      the performance by the Executive of his duties hereunder or that will adversely
      affect, or reflect negatively upon, the Company; provided, however, that the
      Executive may engage in the following activities to the extent that such
      activities, individually or collectively, do not interfere with the performance
      of the Executive’s duties and responsibilities hereunder: (A) fulfilling civic
      responsibilities, (B) attending to personal financial matters, (C) responding
      to
      inquiries from patients and their physicians, (D) serving as an expert witness
      in cases involving Sarcoma, (E) giving and attending academic lectures in
      connection with the Executive’s affiliation with the Yale Medical School, the
      Yale School of Management (Yale’s business school), and the National Academy of
      Sciences, (F) writing and editing medical, scientific and business textbooks,
      (G) serving as a director of Delcath Systems, Inc., the Sarcoma Foundation
      of
      America, and the Police Organization Providing Peer Assistance (POPPA), Inc.
      and
      (H) engaging in such other activities as the Board may approve from time to
      time. 

     

    (b) Acceptance.
      Executive hereby accepts such employment and agrees to render the
      Services.

     

    2. Term.

     

    The
      Executive's employment under this Agreement (the “Term”) shall commence as of
      the Effective Date (as hereinafter defined) and shall continue for a term of
      three (3) years, unless sooner terminated pursuant to Section 9 of this
      Agreement. Notwithstanding anything to the contrary contained herein, the
      provisions of this Agreement governing protection of Confidential Information
      shall continue in effect as specified in Section 6 hereof and survive the
      expiration or termination hereof. The Term may be extended for additional one
      (1) year periods upon mutual written consent of the Executive and the
      Board. 

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    3. Place
      of
      Performance. 

     

    The
      duties to be performed by the Executive hereunder shall be performed primarily
      at the executive offices of the Company in New York, New York, subject to
      reasonable travel requirements on behalf of the Company, or such other place
      as
      the Board may reasonably designate, subject to the provisions of Section 9(d)
      below. The Executive acknowledges that the Company’s operations are conducted
      substantially at its offices in Boston, Massachusetts and that the Executive
      will be required to travel frequently to Boston, Massachusetts.

     

    4. Directorship. 

     

    The
      Company shall use its best efforts to cause the Executive to be elected as
      a
      member of the Board throughout the Term and shall include him in the management
      slate for election as a director at every stockholders meeting during the Term
      at which his term as a director would otherwise expire. The Executive agrees
      to
      accept election, and to serve during the Term, as director of the Company,
      without any compensation therefor other than as specified in this
      Agreement.

     

    5. Compensation.
      As full
      compensation for the performance by the Executive of his duties under this
      Agreement, the Company shall pay the Executive as follows:

     

    (a) Base
      Salary. The
      Company shall pay Executive a salary (the “Base Salary”) equal to Four Hundred
      Twenty Thousand Dollars ($420,000) per year. Payment shall be made semi-monthly,
      on the fifteenth and the last day of each calendar month. The
      Board
      shall annually review the Base Salary to determine whether an increase in the
      amount thereof is warranted.

     

    (b) Performance
      Bonus. The Executive shall receive a targeted performance bonus (the
“Performance
      Bonus”),
      based
      on his performance as determined by the Board for each calendar year ending
      during the Term (each a “Bonus
      Calculation Year”).
      The
      target amount of the Performance Bonus shall be $300,000, with the amount of
      the
      actual bonus payable each year determined in accordance with the provisions
      of
Schedule
      5(b)
      attached
      hereto. The amount so determined shall be payable within 30 days following
      each
      anniversary of the date of this Agreement during the Term, provided
      that the
      Executive remains employed by the Company on such anniversary date.

     

    (c) Discretionary
      Bonus. At the sole discretion of the Board, the Executive shall be eligible
      to
      receive an additional annual bonus (the “Discretionary
      Bonus”)
      in
      such amount as may be determined by the Board based upon his performance on
      behalf of the Company during each Bonus Calculation Year. The Discretionary
      Bonus, if any, shall be payable at such times and in such manner as the Board
      may determine in
      its
      sole discretion. 

     

    (d) Stock
      Options and Restricted Stock Awards. As additional compensation for the services
      to be rendered by the Executive pursuant to this Agreement, the Company shall
      grant the Executive an
      award
      of restricted Common Stock of the Company (“Restricted
      Stock”),
      which
      grant shall be effective as of the date of this Agreement. The Restricted Stock
      shall be governed by the terms of the Company’s Stock Option Plan, as the same
      may be amended from time to time, and shall vest, if at all, in three equal
      annual installments on January 8, 2009, January 8, 2010, and January 8, 2011,
      subject in each case to the provisions of Section 10 below. In connection with
      such grant, the Executive shall enter into a Restricted Stock Agreement with
      the
      Company, which will incorporate the foregoing vesting schedule and the
      Restricted Stock provisions contained in Section 10 below.
      The
      Board shall annually review the equity awards previously granted to the
      Executive to determine whether an increase in the Executive’s long-term equity
      incentive compensation is warranted, and the Executive shall be eligible to
      receive additional equity awards as determined by the Board in its sole
      discretion from time to time. Such additional awards may be in the form of
      additional Restricted Stock or options
      to purchase Common Stock of the Company (“Stock
      Options”),
      or
      both, as the Board may determine in its sole discretion.

     

    (e) Expenses.
      The Company shall reimburse the Executive for all reasonable out of pocket
      expenses incurred by the Executive in furtherance of the business and affairs
      of
      the Company, including reasonable travel and entertainment (which shall include
      business-class travel, unless unavailable and then first-class travel, for
      trips
      requiring air time longer than two (2) hours and the use of car service for
      business-related activities), upon timely receipt by the Company of appropriate
      vouchers or other proof of the Executive’s expenditures and otherwise in
      accordance with any expense reimbursement policy as may from time to time be
      adopted by the Company. The Company’s expense reimbursement policy generally
      requires that application for reimbursement be made as soon as practicable
      after
      the expense is incurred, but in no event more than one year after the date
      of
      the expense. Reimbursements are made by the Company no less frequently than
      monthly.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (f) Life
      and
      Disability Insurance. The Company shall reimburse the Executive all premiums
      paid by the Executive on life insurance policies covering the Executive in
      amounts up to $800,000 and disability insurance policies covering the Executive
      in amounts up to $20,000 per month.

     

    (g) Vacation.
      The Executive shall, during the Term, be entitled to a vacation of four (4)
      weeks per annum,
      in
      addition to holidays observed by the Company.
      The
      Executive shall not be entitled to carry any vacation forward to the next year
      of employment and shall not receive any compensation for unused vacation
      days.

     

    (h) Other
      Benefits. 

     

    (i) The
      Executive shall be entitled to all rights and benefits for which he shall be
      eligible under any benefit or other plans (including, without limitation,
      dental, medical, medical reimbursement and hospital plans, pension plans,
      employee stock purchase plans, profit sharing plans, bonus plans and other
      so-called "fringe" benefits) as the Company shall make available to any of
      its
      senior executives from time to time.

     

    (ii) The
      Company shall reimburse the Executives for his reasonable medical licensing
      fees
      and other professional dues and memberships and journal subscriptions. In
      addition, the Company shall reimburse the Executive up to $10,000 per annum
      for
      costs associated with a consulting group retained by the Executive for the
      purpose of assisting the Executive corporate decision making. These expenses
      will be reimbursed in accordance with the expense reimbursement policy outlined
      in Section 5(e) above.

     

    6. Confidential
      Information and Inventions.

     

    (a) The
      Executive recognizes and acknowledges that in the course of his duties he is
      likely to receive confidential or proprietary information owned by the Company,
      its affiliates or third parties with whom the Company or any of such affiliates
      has an obligation of confidentiality. Accordingly, during and after the Term,
      the Executive agrees to keep confidential and not disclose or make accessible
      to
      any other person or use for any other purpose other than in connection with
      the
      fulfillment of his duties under this Agreement, any Confidential and Proprietary
      Information (as defined below) owned by, or received by or on behalf of, the
      Company or any of its affiliates. “Confidential and Proprietary Information”
shall include, but shall not be limited to, confidential or proprietary
      scientific or technical information, data, formulas and related concepts,
      business plans (both current and under development), client lists, promotion
      and
      marketing programs, trade secrets, or any other confidential or proprietary
      business information relating to development programs, costs, revenues,
      marketing, investments, sales activities, promotions, credit and financial
      data,
      manufacturing processes, financing methods, plans or the business and affairs
      of
      the Company or of any affiliate or client of the Company. The Executive
      expressly acknowledges the trade secret status of the Confidential and
      Proprietary Information and that the Confidential and Proprietary Information
      constitutes a protectable business interest of the Company. The Executive
      agrees: (i) not to use any such Confidential and Proprietary Information for
      himself or others; and (ii) not to take any Company material or reproductions
      (including but not limited to writings, correspondence, notes, drafts, records,
      invoices, technical and business policies, computer programs or disks) thereof
      from the Company’s offices at any time during his employment by the Company,
      except as required in the execution of the Executive’s duties to the Company.
      The Executive agrees to return immediately all Company material and
      reproductions (including but not limited, to writings, correspondence, notes,
      drafts, records, invoices, technical and business policies, computer programs
      or
      disks) thereof in his possession to the Company upon request and in any event
      immediately upon termination of employment.

     

    (b) Except
      in
      furtherance of the business of the Company, or otherwise with prior written
      authorization by the Company, the Executive agrees not to disclose or publish
      any of the Confidential and Proprietary Information, or any confidential,
      scientific, technical or business information of any other party to whom the
      Company or any of its affiliates owes an obligation of confidence, at any time
      during or after his employment with the Company. Nothing in the foregoing shall
      be construed to prevent the Executive from disclosing or using any Confidential
      or Proprietary Information that:

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (i) 
      Executive can evidence through written documentation was in the Executive’s
      possession or control prior to the date of disclosure;

     

    (ii) 
      Executive can evidence through written documentation was in the public domain
      or
      enters into the public domain through no improper act by Executive

     

    (iii) 
      is
      approved for public release by written authorization of the Board;

     

    (iv) 
      is
      required to be disclosed by legal, administrative or judicial process;
      or

     

    (v) is
      rightfully granted to Executive by sources independent of the Company, its
      officers, employees, agents, affiliates and consultants.

     

    (c) The
      Executive agrees that all inventions, discoveries, improvements and patentable
      or copyrightable works (“Inventions”)
      initiated, conceived or made by him, either alone or in conjunction with others,
      during the Term
      shall be
      the sole property of the Company to the maximum extent permitted by applicable
      law and, to the extent permitted by law, shall be “works made for hire” as that
      term is defined in the United States Copyright Act (17 U.S.C.A., Section 101).
      The Company shall be the sole owner of all patents, copyrights, trade secret
      rights, and other intellectual property or other rights in connection therewith.
      The Executive hereby assigns to the Company all right, title and interest he
      may
      have or acquire in all such Inventions; provided, however, that the Board may
      in
      its sole discretion agree to waive the Company’s rights pursuant to this Section
      6(c) with respect to any Invention that is not directly or indirectly related
      to
      the Company’s business. The Executive further agrees to assist the Company in
      every proper way (but at the Company’s expense) to obtain and from time to time
      enforce patents, copyrights or other rights on such Inventions in any and all
      countries, and to that end the Executive will execute all documents
      necessary:

     

    (i) to
      apply
      for, obtain and vest in the name of the Company alone (unless the Company
      otherwise directs) letters patent, copyrights or other analogous protection
      in
      any country throughout the world and when so obtained or vested to renew and
      restore the same; and

    (ii) to
      defend
      any opposition proceedings in respect of such applications and any opposition
      proceedings or petitions or applications for revocation of such letters patent,
      copyright or other analogous protection.

     

    (d) The
      Executive acknowledges that while performing the services under this Agreement
      the Executive may locate, identify and/or evaluate patented or patentable
      inventions having commercial potential in the fields of pharmacy,
      pharmaceutical, biotechnology, healthcare, technology and other fields which
      may
      be of potential interest to the Company (the “Third
      Party Inventions”).
      The
      Executive understands, acknowledges and agrees that all rights to, interests
      in
      or opportunities regarding, all Third-Party Inventions identified by the
      Company, any of its officers, directors, employees (including the Executive),
      agents or consultants during the Term as being of potential interest to the
      Company shall be and remain the sole and exclusive property of the Company
      and
      the Executive shall have no rights whatsoever to such Third-Party Inventions
      and
      will not pursue for himself or for others any transaction relating to the
      Third-Party Inventions which is not on behalf of the Company.

     

    (e) The
      provisions of this Section 6 shall survive any termination of this
      Agreement.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    7. Non-Competition,
      Non-Solicitation and Non-Disparagement.

     

    (a) The
      Executive understands and recognizes that his services to the Company are
      special and unique and that in the course of performing such services the
      Executive will have access to and knowledge of Confidential and Proprietary
      Information (as defined in Section 6) and the Executive agrees that, during
      the
      Term and for a period of twelve
      (12) months
      thereafter (subject to the provisions of Section 10(e) hereof), he shall not
      without the consent of the Company in any manner, directly or indirectly, on
      behalf of himself or any person, firm, partnership, joint venture, corporation
      or other business entity (“Person”),
      enter
      into or engage in any business which is engaged in any business directly or
      indirectly competitive with the Company’s Business (as defined below), either as
      an individual for his own account, or as a partner, joint venturer, owner,
      executive, employee, independent contractor, principal, agent, consultant,
      salesperson, officer, director or shareholder of a Person in a business
      competitive with the Company within the geographic area of the Company’s
      Business, which is deemed by the parties hereto to be worldwide. The Executive
      acknowledges that, due to the nature of the Company’s Business, and the
      importance to the Company’s Business of its Confidential and Proprietary
      Information, a violation of this Section 7(a) could cause substantial damage
      to
      the Company and its affiliates and, therefore, the Company has a strong
      legitimate business interest in protecting the continuity of its business
      interests and the restriction herein agreed to by the Executive narrowly and
      fairly serves such an important and critical business interest of the Company.
      For purposes of this Agreement, the “Company’s Business” shall mean the business
      or businesses set forth on the attached Schedule 7(a), which shall be amended
      from time to time upon the mutual written agreement of the parties, but which
      will automatically include the research, development and commercialization
      of
      any technologies that are licensed or otherwise acquired by the Company.
      Notwithstanding the foregoing, nothing contained in this Section 7(a) shall
      be
      deemed to prohibit the Executive from (i) acquiring or holding, solely for
      investment, publicly traded securities of any corporation, some or all of the
      activities of which are competitive with the business of the Company so long
      as
      such securities do not, in the aggregate, constitute more than three percent
      (3%) of any class or series of outstanding securities of such
      corporation.

     

    (b) During
      the Term and for a period of twelve (12) months thereafter (subject to the
      provisions of Section 10(e) hereof), the Executive shall not, directly or
      indirectly, without the prior written consent of the Company:

     

    (i) solicit
      or induce any employee of the Company to leave the employ of the Company; or
      hire for any purpose any employee of the Company or any employee who has left
      the employment of the Company within six months of the termination of such
      employee’s employment with the Company or at any time in violation of such
      employee’s non-competition agreement with the Company; or

     

    (ii) solicit
      or accept employment or be retained by any Person who, at any time during the
      term of this Agreement, was an agent, client or customer of the Company where
      his position will be related to the Company’s Business; or

    

    (iii) solicit
      or accept the business of any agent, client or customer of the Company with
      respect to products, services or investments similar to those provided or
      supplied by the Company.

    

    (c) The
      Company and the Executive each agree that both during the Term and at all times
      thereafter, neither party shall directly or indirectly disparage, whether or
      not
      true, the name or reputation of the other party or any of its affiliates,
      including but not limited to, any officer, director, employee or stockholder
      owning greater than five percent (5%) of the Company’s outstanding Common Stock.
      This Section 7(c) shall not apply to (i) statements made by the Executive’s in
      performing his duties in the ordinary course as Chief Executive Officer
      (e.g.,
      employee evaluations and remarks made in private meetings of the Board) and
      (ii)
      statements made by the Executive under oath in a legal proceeding, including
      without limitation an investigation or administrative proceeding before any
      governmental agency or instrumentality with regulatory authority over the
      Company or its business.

     

    (d) In
      the
      event that the Executive breaches any provisions of Section 6 or this Section
      7
      or there is a threatened breach, then, in addition to any other rights which
      the
      Company may have, the Company shall (i) be entitled, without the posting of
      a
      bond or other security, to injunctive relief to enforce the restrictions
      contained in such Sections and (ii) have the right to require the Executive
      to
      account for and pay over to the Company all compensation, profits, monies,
      accruals, increments and other benefits (collectively “Benefits”)
      derived or received by the Executive as a result of any transaction constituting
      a breach of any of the provisions of Sections 6 or 7 and the Executive hereby
      agrees to account for and pay over such Benefits to the Company.

     

    (e) Each
      of
      the rights and remedies enumerated in Section 7(d) shall be independent of
      the
      others and shall be in addition to and not in lieu of any other rights and
      remedies available to the Company at law or in equity. If any of the covenants
      contained in this Section 7, or any part of any of them, is hereafter construed
      or adjudicated to be invalid or unenforceable, the same shall not affect the
      remainder of the covenant or covenants or rights or remedies which shall be
      given full effect without regard to the invalid portions. If any of the
      covenants contained in this Section 7 is held to be invalid or unenforceable
      because of the duration of such provision or the area covered thereby, the
      parties agree that the court making such determination shall have the power
      to
      reduce the duration and/or area of such provision and in its reduced form such
      provision shall then be enforceable. No such holding of invalidity or
      unenforceability in one jurisdiction shall bar or in any way affect the
      Company’s right to the relief provided in this Section 7 or otherwise in the
      courts of any other state or jurisdiction within the geographical scope of
      such
      covenants as to breaches of such covenants in such other respective states
      or
      jurisdictions, such covenants being, for this purpose, severable into diverse
      and independent covenants.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (f) In
      the
      event that an actual proceeding is brought in equity to enforce the provisions
      of Section 6 or this Section 7, the Executive shall not urge as a defense that
      there is an adequate remedy at law nor shall the Company be prevented from
      seeking any other remedies which may be available. 

     

    (g) The
      provisions of this Section 7 shall survive any termination of this
      Agreement.

     

    8. Representations
      and Warranties by the Executive.

     

    The
      Executive hereby represents and warrants to the Company that
      (a)
      the Executive has the full right, power and legal capacity to enter and deliver
      this Agreement and to perform his duties and other obligations hereunder; (b)
      this Agreement constitutes the legal, valid and binding obligation of the
      Executive enforceable against him in accordance with its terms; and (c) no
      approvals or consents of any persons or entities are required for the Executive
      to execute and deliver this Agreement or perform his duties and other
      obligations hereunder.

     

    9. Termination.
      The Executive’s employment hereunder shall be terminated upon the Executive’s
      death and may be terminated as follows:

     

    (a) The
      Executive’s employment hereunder may be terminated by the Board for Cause. Any
      of the following actions by the Executive shall constitute “Cause”:

     

    (i) The
      willful misconduct, failure, disregard or refusal by the Executive to perform
      any of the material duties of his employment hereunder including, without
      limitation, insubordination with respect to written directions received by
      the
      Executive from the Board, provided, however, that the Executive shall have
      one
      (1) opportunity to cure any breach of this section 9(a)(i) within five (5)
      business days (‘Cure Period”) of written notice to the Executive;

    

    (ii) Any
      willful, intentional or grossly negligent act by the Executive having the effect
      of injuring, in a material way (whether financial or otherwise and as determined
      in good faith by a majority of the Board), the business or reputation of the
      Company or any of its affiliates, including but not limited to, any officer,
      director, executive of the Company or any stockholder owning greater than five
      percent (5%) of the Company’s outstanding Common Stock; provided, however, that
      the Executive shall be granted an opportunity to appear personally before the
      Board during its deliberations to explain the reasons for such conduct;

     

    (iii) The
      Executive’s conviction of any felony or a misdemeanor involving moral turpitude
      (including entry of a nolo contendere
      plea);

     

    (iv) The
      determination by the Company, after a reasonable and good-faith investigation
      by
      the Company following a written allegation by another employee of the Company,
      that the Executive engaged in some form of harassment prohibited
      by law
      (including, without limitation, harassment that constitutes age, sex or race
      discrimination),
      unless
      the Executive’s actions were specifically directed by the Board;

     

    (v) Any
      misappropriation or embezzlement of the property of the Company or its
      affiliates;

     

    (vi) Breach
      by
      the Executive of any of the provisions of Sections
      6, 7
      or
8
      of this
      Agreement; and

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (vii) Breach
      by
      the Executive of any provision of this Agreement other than those contained
      in
Sections
      6, 7
      or
8
      which is
      not cured by the Executive within thirty (30) days after notice thereof is
      given
      to the Executive by the Company.

    

    (b) The
      Executive’s employment hereunder may be terminated by the Board due to the
      Executive’s Disability. For purposes of this Agreement, a termination for
“Disability”
shall
      occur upon rendering of a written termination notice by the Board after the
      Executive has been unable to substantially perform his duties hereunder for
      90
      or more consecutive days, or more than 120 days in any consecutive 12 month
      period, by reason of any physical or mental illness or injury. For purposes
      of
      this Section 9(b), the Executive agrees to make himself available and to
      cooperate in any reasonable examination by a reputable independent physician
      retained by the Company.

     

    (c) The
      Executive’s employment hereunder may be terminated by the Board (or its
      successor) upon the occurrence of a Change of Control. For purposes of this
      Agreement, “Change
      of Control”
means
      (i) the acquisition, directly or indirectly, following the date hereof by any
      person (as such term is defined in Section 13(d) and 14(d)(2) of the Securities
      Exchange Act of 1934, as amended), in one transaction or a series of related
      transactions, of securities of the Company representing in excess of fifty
      percent (50%) or more of the combined voting power of the Company’s then
      outstanding securities if such person (or his or its affiliate(s)) does not
      own
      in excess of 50% of such voting power on the date of this Agreement, or (ii)
      the
      future disposition by the Company (whether direct or indirect, by sale of assets
      or stock, merger, consolidation or otherwise) of all or substantially all of
      its
      assets in one transaction or series of related transactions (other than (i)
      a
      merger effected exclusively for the purpose of changing the domicile of the
      Company, (ii) financing activities in the ordinary course in which the Company
      sells its equity securities, or (iii) a transfer to a person or entity that,
      immediately after the transfer, is or is controlled by a person or entity that
      controlled the Company before the transfer, within the meaning of Section
      1.409A-3(i)(5)(vii)(B) of the Treasury Regulations).

     

    (d) The
      Executive’s employment hereunder may be terminated by the Executive for Good
      Reason, provided
      that
      such termination occurs within two (2) years following the occurrence of an
      event of Good Reason (as defined below) and provided,
      further,
      that
      the Executive has provided the Board with written notice of an event of Good
      Reason within ninety (90) days following the date of its occurrence and the
      Company shall have failed to cure the event of Good Reason within thirty (30)
      days following the Board’s receipt of such notice from the Executive. For
      purposes of this Agreement, “Good
      Reason”
shall
      mean any of the following: (i) the assignment to the Executive of duties
      that constitute a material diminution in the Executive's position,
      responsibilities, titles or offices as described herein; (ii) any material
      reduction by the Company of the Executive's duties and responsibilities;
      (iii) any reduction by the Company of the Executive's compensation or
      benefits payable hereunder (it being understood that a reduction of benefits
      applicable to all employees of the Company, including the Executive, shall
      not
      be deemed a reduction of the Executive's compensation package for purposes
      of
      this definition); (iv) a material breach by the Company of this Agreement;
      (v)
      moving the primary place of business of the Executive to a location that is
      more
      than 60 miles from Fairfield, Connecticut; or (vi) upon a Change of Control
      (x)
      that results in the elimination of the Board or
      (y) in
      which representatives of the Board just prior to the event causing the Change
      of
      Control do not represent a majority of the Board immediately subsequent to
      the
      event causing the Change of Control.

     

    10. Compensation
      Following Termination.

     

    (a) If
      the
      Executive’s employment is terminated as a result of his death or Disability, the
      Company shall pay to the Executive or to the Executive’s estate, as applicable,
his
      Base
      Salary for a period of one year following the date of termination and any
      accrued but unpaid Performance Bonus, Discretionary Bonus and expense
      reimbursement amounts for expense incurred through the date of his Death or
      Disability. All Stock Options and Restricted Stock that are
      scheduled to vest by the end of the calendar year in which such termination
      occurs shall be accelerated and deemed to have vested as of the termination
      date. Any Stock Options that have vested (or been deemed pursuant to the
      immediately preceding sentence to have vested) as
      of the
      date of the Executive’s termination shall remain exercisable for a period of 90
      days.
      All
      Stock
      Options and Restricted Stock that have
      not
      vested as
      of the
      date of termination shall be deemed to have expired as of such
      date.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (b) If
      the
      Executive’s employment is terminated by the Board for Cause, then the Company
      shall pay to the Executive his Base Salary through the date of his termination
      and any expense reimbursement amounts for expense incurred through the date
      of
      termination. The Executive shall have no further entitlement to any other
      compensation or benefits from the Company. All
      Stock
      Options and Restricted Stock that have
      not
      vested as
      of the
      date of termination shall be deemed to have expired as of such date.
      Any
      Stock Options that have vested as of the date of the Executive’s termination for
      Cause shall remain exercisable for a period of 90 days.

     

    (c) If
      the
      Executive’s employment is terminated by the Company (or its successor) without
      Cause and either (i) within eighteen (18) months following the occurrence of
      a
      Change of Control or (ii) prior to and in connection with the occurrence of
      a
      Change in Control, then the Company (or its successor, as applicable) shall
      continue to pay to the Executive his Base Salary and Benefits for a period
      of
      two years following such termination of employment, as well as any expense
      reimbursement amounts for expenses incurred through the date of termination.
      In
      addition, the Company shall pay to the Executive the Performance Bonus that
      would have been payable for the Bonus Calculation Year in which termination
      of
      his employment occurs. For this purpose, the amount of Performance Bonus shall
      be the greater of
      (x) the
      amount determined pursuant to Schedule
      5(b)
      or (y)
      the average of the amounts payable to the Executive as Performance Bonus or
      Guaranteed Bonus (as determined under the Employment Agreement dated as of
      January 8, 2004 by and between the Executive and the Company’s predecessor) for
      the two years immediately preceding the year of termination of the Executive’s
      employment. All Stock Options and Restricted Stock that are scheduled to vest
      by
      the end of the calendar year in which such termination occurs shall be
      accelerated and deemed to have vested as of the termination date. Any Stock
      Options that have vested (or been deemed pursuant to the immediately preceding
      sentence to have vested) as
      of the
      date of the Executive’s termination shall remain exercisable for a period of 90
      days.

     

    (d) If
      the
      Executive’s employment is terminated by the Company without Cause other than as
      a result of the Executive’s death or Disability and other than for reasons
      specified in Section 10(c), or if the Executive’s employment is terminated by
      the Executive for Good Reason, then the Company shall continue to pay to the
      Executive his Base Salary and Benefits for a period of one year following such
      termination, as well as any expense reimbursement amounts for expenses incurred
      through the date of termination. In addition, the Company shall pay to the
      Executive a portion of the Performance Bonus that would have been payable for
      the Bonus Calculation Year in which termination of his employment occurs, which
      portion shall be determined pro rata
      based on
      the number of days in such Bonus Calculation Year on which the Executive was
      employed by the Company. For this purpose, the amount of Performance Bonus
      shall
      be determined pursuant to Schedule
      5(b),
      provided
      that all
      performance targets shall be deemed to have been met for the bonus calculation
      year. All Stock Options and Restricted Stock scheduled
      to vest by the end of the calendar year in which such termination occurs
shall
      be
      accelerated and deemed to have vested as of the termination date. Any
      Stock
      Options that have vested (or been deemed pursuant to this Section 10(d)) as
      of
      the date of the Executive’s termination shall remain exercisable for a period of
      90 days.

     

    (e) Following
      expiration and non-renewal of the Term, should the Company in its sole
      discretion require that the Executive continue to comply with the terms of
      Section 7(a) or Section 7(b) hereof, or both, the Company shall pay the
      Executive his Base Salary and Performance Bonus for a period of one year
      following expiration of the Term. For this purpose, the amount of Performance
      Bonus shall be the average of the amounts payable to the Executive as
      Performance Bonus for the two Bonus Calculation Years immediately preceding
      the
      expiration of the Term.

     

    (f) This
      Section 10 sets forth the only obligations of the Company with respect to the
      termination of the Executive’s employment with the Company, and the Executive
      acknowledges that, upon the termination of his employment, he shall not be
      entitled to any payments or benefits which are not explicitly provided in
      Section 10.

     

    (g) Upon
      termination of the Executive’s employment hereunder for any reason, the
      Executive shall be deemed to have resigned as director of the Company, effective
      as of the date of such termination.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (h) Amounts
      payable to the Executive pursuant to Sections 10(a), 10(c) 10(d), or 10(e)
      hereof shall only be paid following the Executive’s separation from service with
      the Company. The time for payment of amounts due following the Executive’s
      separation from service pursuant to this Section 10 shall be determined in
      accordance with the Company’s regular payroll and bonus payment practices,
      subject to the provisions of Section 409A of the Internal Revenue Code of 1986,
      as amended, and the Treasury Regulations promulgated therender. Payments of
      Base
      Salary following separation from service shall be made semi-monthly at the
      same
      times as, and in accordance with, the Company’s regular payroll payments.
      Payments for Performance Bonus, Discretionary Bonus or expense reimbursements
      accrued with respect to periods of service completed prior to the Executive’s
      separation from service, but unpaid at the time of termination of employment,
      shall be due and payable at the same times as they otherwise would be due in
      accordance with the Company’s regular bonus payment practices (i.e.,
      Performance Bonus within 30 days following the end of the Bonus Calculation
      Year; Discretionary Bonus within 2 months following the end of a calendar year
      for which bonus is granted), and payments in lieu of Performance Bonus for
      the
      Bonus Calculation Year in which termination of employment occurs or for any
      Bonus Calculation Year following termination of employment, payable pursuant
      to
      Section 10(c), 10(d), or 10(e) above, shall be payable either (i) at the same
      time as they otherwise would be due in accordance with this Agreement if the
      Executive’s employment had not terminated, or (ii) on the day following the date
      that is six (6) months after the date of the Executive’s separation from
      service, whichever is later. Notwithstanding any other provision of this
      Agreement, no amount of Base Salary, Performance Bonus, and Discretionary Bonus
      payable to the Executive by reason of the Executive’s termination of his
      employment pursuant to Section 9(d) above, other than a termination by reason
      of
      Section 9(d)(vi), and no amount in excess of $420,000 payable following the
      Executive’s separation from service for any reason shall be paid earlier than
      the day following the date that is six (6) months after the date of the
      Executive’s separation from service with the Company. For purposes of this
      section 10(h), the term “separation from service” shall have the meaning set
      forth in Section 1.409A-1(h)(1) of the Treasury Regulations, and the Executive
      shall be deemed to be a “key employee” for purposes of such Treasury
      Regulations.

     

    (i) The
      provisions of this Section 10 shall survive any termination of this
      Agreement.

     

    11. Miscellaneous.

     

    (a) Withholding.
      The Company shall withhold from all amounts payable to the Executive under
      this
      Agreement all applicable federal, state and local income taxes, Social Security
      contributions and such other payroll taxes and deductions as may be required
      by
      law.

     

    (b) This
      Agreement shall be governed by, and construed and interpreted in accordance
      with, the laws of the State of New York, without giving effect to its principles
      of conflicts of laws.

     

    (c) Any
      dispute arising out of, or relating to, this Agreement or the breach thereof
      (other than Sections 6 or 7 hereof), or regarding the interpretation thereof,
      shall be finally settled by arbitration conducted in New York City in accordance
      with the Employment Dispute Rules of the American Arbitration Association then
      in effect before a single arbitrator appointed in accordance with such rules.
      Judgment upon any award rendered therein may be entered and enforcement obtained
      thereon in any court having jurisdiction. The arbitrator shall have authority
      to
      grant any form of appropriate relief, whether legal or equitable in nature,
      including specific performance. For the purpose of any judicial proceeding
      to
      enforce such award or incidental to such arbitration or to compel arbitration
      and for purposes of Sections 6 and 7 hereof, the parties hereby submit to the
      non-exclusive jurisdiction of the Supreme Court of the State of New York, New
      York County, or the United States District Court for the Southern District
      of
      New York, and agree that service of process in such arbitration or court
      proceedings shall be satisfactorily made upon it if sent by registered mail
      addressed to it at the address referred to in paragraph (g) below. The costs
      of
      such arbitration shall be borne proportionate to the finding of fault as
      determined by the arbitrator. Judgment on the arbitration award may be entered
      by any court of competent jurisdiction.

     

    (d) This
      Agreement shall be binding upon and inure to the benefit of the parties hereto,
      and their respective heirs, legal representatives, successors and permitted
      assigns.

     

    (e) This
      Agreement, and the Executive’s rights and obligations hereunder, may not be
      assigned by the Executive. The Company may assign its rights, together with
      its
      obligations, hereunder in connection with any sale, transfer or other
      disposition of all or substantially all of its business or assets and shall
      cause the acquirer to assume all of its obligations under this
      Agreement.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (f) This
      Agreement cannot be amended orally, or by any course of conduct or dealing,
      but
      only by a written agreement signed by the parties hereto.

     

    (g) The
      failure of either party to insist upon the strict performance of any of the
      terms, conditions and provisions of this Agreement shall not be construed as
      a
      waiver or relinquishment of future compliance therewith, and such terms,
      conditions and provisions shall remain in full force and effect. No waiver
      of
      any term or condition of this Agreement on the part of either party shall be
      effective for any purpose whatsoever unless such waiver is in writing and signed
      by such party.

     

    (h) All
      notices, requests, consents and other communications, required or permitted
      to
      be given hereunder, shall be in writing and shall be delivered personally or
      by
      an overnight courier service or sent by registered or certified mail, postage
      prepaid, return receipt requested, to the parties at the addresses set forth
      on
      the first page of this Agreement, and shall be deemed given when so delivered
      personally or by overnight courier, or, if mailed, five days after the date
      of
      deposit in the United States mails. Either party may designate another address,
      for receipt of notices hereunder by giving notice to the other party in
      accordance with this Section 11(g).

     

    (i) This
      Agreement sets forth the entire agreement and understanding of the parties
      relating to the subject matter hereof, and supersedes all prior agreements,
      arrangements and understandings, written or oral, relating to the subject matter
      hereof. No representation, promise or inducement has been made by either party
      that is not embodied in this Agreement, and neither party shall be bound by
      or
      liable for any alleged representation, promise or inducement not so set
      forth.

     

    (j) As
      used
      in this Agreement, “affiliate” of a specified Person shall mean and include any
      Person controlling, controlled by or under common control with the specified
      Person.

     

    (k) The
      section headings contained herein are for reference purposes only and shall
      not
      in any way affect the meaning or interpretation of this Agreement.

     

    (l) This
      Agreement may be executed in any number of counterparts, each of which shall
      constitute an original, but all of which together shall constitute one and
      the
      same instrument.

     

     

    IN
      WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
      date
      first above written.

     

    
      	
              ZIOPHARM
                Oncology, Inc.

            
	 	 
	
              By:

            	
              /s/
                Richard E. Bagley

            
	 	
              Name:
                Richard E. Bagley

            
	 	
              Title:
                President, Chief Operating Officer and Chief Financial
                Officer

            
	 	 
	
              EXECUTIVE

            
	 	 
	
              By:

            	
              /s/
                Jonathan J. Lewis

            
	 	
              Name:
                Jonathan J. Lewis, M.D., Ph.D.

            

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

     SCHEDULE
      5(b)

    

    Calculation
      of Performance Bonus

    

    Prior
      to
      the beginning of each Bonus Calculation Year during the Term, the Executive
      and
      the Compensation Committee of the Board shall agree upon five (5) performance
      goals (“Targets”) for the Bonus Calculation Year. The amount of Performance
      Bonus payable to the Executive pursuant to Section 5(b) of this Agreement for
      any Bonus Calculation Year shall be determined based on the Executive’s
      achievement of the Targets as follows: 

    

    With
      respect to each of the Targets, the Executive will receive $60,000 in
      Performance Bonus if the Target is met on or before the end of the Bonus
      Calculation Year (e.g.,
      Performance Bonus of $300,000 if all Targets are met). 

    

    The
      Executive will receive $50,000 in Performance Bonus with respect to any Target
      that has not been met on or before the end of the Bonus Calculation Year,
provided
      that
either
      of the
      following has occurred: (1) (a) the Executive has devoted his reasonable best
      business efforts toward achievement the Target during the Bonus Calculation
      Year, and (b) substantial progress toward accomplishment of the Target has
      occurred during the Bonus Calculation Year; or
      (2)
      during the Bonus Calculation Year, the Company abandoned the business goal
      that
      the Target was intended to address (e.g.,
      Performance Bonus of $250,000 if no Target is met, but the Executive has devoted
      his reasonable best business efforts to achievement of all of the
      Targets).

    

    The
      Executive will receive $72,000 in Performance Bonus with respect to any Target
      if the Target is exceeded during the Bonus Calculation Year and the Board
      determines that the Executive’s performance with respect to the Target exceeded
      expectations (e.g.,
      Performance Bonus of $360,000 if the Executive’s performance with respect to all
      Targets exceeded expectations).

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    SCHEDULE
      7(a)

    

    1. Developing,
      designing, producing, marketing, selling or rendering oncology products in
      the
      class of arsenicals, products in the phosphoramidic nitrogen mustard family
      and
“mustard gas family,” and anti-mitotics with the same mechanism as that in
      indibulin or products that are in the same chemical family as those that have
      been or are being developed, designed, produced, marketed, sold or rendered
      by
      the Corporation during the period of the Executive’s employment with the
      Company.

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