Document:

EX-10.1

 Execution Version 

Exhibit 10.1 

REGISTRATION RIGHTS AGREEMENT 
 THIS
REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of May 4, 2021, is by and among Pioneer Natural Resources Company, a Delaware corporation (the “Company”), each of the other parties listed on the signature
pages attached hereto (the “Initial Holders”), and the other Holders from time to time parties hereto. 
 RECITALS:

 WHEREAS, this Agreement is being entered into pursuant to the Membership Interest Purchase Agreement, dated as of April 1, 2021, by and among
Double Eagle III Midco 2 LLC, Pioneer Natural Resources USA, Inc. and the Company (the “Purchase Agreement”); 
 WHEREAS, in connection
with closing of the transactions contemplated by the Purchase Agreement, on the date hereof the Company is issuing to the Initial Holders 27,187,500 shares of Company Common Stock (such shares of Company Common Stock, the “Shares”)
in the aggregate; and 
 NOW THEREFORE, in consideration of the mutual covenants and agreements set forth herein and for good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged by each party hereto, the parties hereby agree as follows: 
 ARTICLE I

 DEFINITIONS 
 As used herein, the
following terms shall have the following respective meanings: 
 “Adoption Agreement” means an Adoption Agreement in the form attached
hereto as Exhibit A. 
 “Affiliate” means (a) as to any Person, other than an individual Holder, any other Person who directly,
or indirectly through one or more intermediaries, controls, is controlled by or is under common control with such Person and (b) as to any individual, (i) any Relative of such individual, (ii) any trust whose primary beneficiaries are
one or more of such individual and such individual’s Relatives, (iii) the legal representative or guardian of such individual or any of such individual’s Relatives if one has been appointed and (iv) any Person controlled by one
or more of such individual or any Person referred to in clauses (i), (ii) or (iii) above. As used in this definition, the term “control,” including the correlative terms “controlling,” “controlled by” and
“under common control with,” means possession, directly or indirectly, of the power to direct or cause the direction of management or policies (whether through ownership of securities or any partnership or other ownership interest, by
contract or otherwise) of a Person. For the avoidance of doubt, for purposes of this Agreement, (a) (i) the Company, on the one hand, and the Holders, on the other hand, shall not be considered Affiliates and (ii) any fund, entity or
account managed, advised or sub-advised, directly or indirectly, by a Holder or any of its Affiliates, shall be considered an Affiliate of such Holder and (b) with respect to any fund, entity or account
managed, advised or sub-advised directly or indirectly, by any Holder or any of its Affiliates, the direct or indirect equity owners thereof, including limited partners of any Holder or any Affiliate thereof,
shall be considered an Affiliate of such Holder. 
 “Agreement” has the meaning set forth in the introductory paragraph. 

“Apollo Holders” means ANRP II Double Eagle Energy Holdings III, L.P., AP VIII Double Eagle Energy Holdings III, L.P. and Double Eagle Energy
Holdings III LLC and any Affiliates thereof that hold Registrable Securities. 
 “Board” means the board of directors of the Company. 

“Business Day” means any day other than a Saturday, Sunday, any federal holiday or any other day on which banking institutions in the State
of Texas or the State of New York are authorized or required to be closed by law or governmental action. 
 “Commission” means the
Securities and Exchange Commission or any successor governmental agency. 
 “Company” has the meaning set forth in the introductory
paragraph. 

 “Company Common Stock” means the common stock of the Company, par value $0.01 per share.

 “Company Securities” has the meaning set forth in Section 2.4(c)(i). 

“Effectiveness Period” has the meaning set forth in Section 2.1(c). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, or any successor federal statute, and the rules and regulations of the
Commission thereunder, all as the same shall be in effect at the time. 
 “Indemnified Party” has the meaning set forth in
Section 3.3. 
 “Indemnifying Party” has the meaning set forth in Section 3.3. 

“Holder” means any record holder of Registrable Securities. 

“Losses” has the meaning set forth in Section 3.1. 

“Majority Holders” means, at any time, the Holder or Holders of more than 50% of the Registrable Securities at such time. 

“Managing Underwriter” means, with respect to any Underwritten Offering, the lead book-running manager(s) of such Underwritten Offering. 

“Minimum Number of Registrable Securities” means (i) during the six-month period following the
date of this Agreement, for the purposes of Section 2.2 of this Agreement, one Registrable Security and (ii) in all other circumstances, 100,000 Registrable Securities; provided, however, that in the case of the
preceding clause (ii), such number of Registrable Securities shall be appropriately adjusted in connection with any event described in Section 6.4. 

“Opt-Out Notice” has the meaning set forth in Section 2.11 

“Other Securities” has the meaning set forth in Section 2.4(c)(i). 

“Permitted Transferee” means (a) with respect to any Initial Holder, any of the direct or indirect partners, shareholders or members of
such Initial Holder or any trust, family partnership or family limited liability company, the sole beneficiaries, partners or members of which are such Initial Holder or Relatives of such Initial Holder and (b) any Affiliate of a Holder, in
each case provided that such Transferee has delivered to the Company a duly executed Adoption Agreement. 
 “Person” means any individual,
corporation, partnership, limited liability company, firm, association, trust, government, governmental agency or other entity, whether acting in an individual, fiduciary or other capacity. 

“Piggybacking Holder” has the meaning set forth in Section 2.4(a). 

“Piggyback Underwritten Offering” has the meaning set forth in Section 2.4(a). 

“Purchase Agreement” has the meaning set forth in the recitals. 

“Quantum Holders” means FourPoint Permian, LLC and Q-FPP (VII) Subsidiary, LLC and any
Affiliates thereof that hold Registrable Securities. 
 “Registrable Securities” means (a) the Shares and (b) any securities
issued or issuable with respect to the Shares by way of distribution or in connection with any reorganization or other recapitalization, merger, consolidation or otherwise; provided, however, that a Registrable Security shall cease to be a
Registrable Security when (i) a Registration Statement covering such Registrable Security has become effective under the Securities Act and such Registrable Security has been disposed of pursuant to such Registration Statement, (ii) such
Registrable Security is disposed of under Rule 144 under the Securities Act or any other exemption from the registration requirements of the Securities Act as a result of which the legend on any certificate or book-entry notation representing such
Registrable 

 
Security restricting transfer of such Registrable Security has been removed, or (iii) such Registrable Security has been sold or disposed of in a transaction in which the Transferor’s
rights under this Agreement are not assigned to the Transferee pursuant to Section 5.2; and provided, further, that any security that has ceased to be a Registrable Security shall not thereafter become a Registrable
Security and any security that is issued or distributed in respect of securities that have ceased to be Registrable Securities shall not be a Registrable Security. 

“Registration Expenses” means all expenses incurred by the Company in complying with Article II, including, without limitation, all
registration and filing fees, printing expenses, road show expenses, fees and disbursements of counsel and independent public accountants for the Company, fees and expenses (including counsel fees) incurred in connection with complying with state
securities or “blue sky” laws, fees of the Financial Industry Regulatory Authority, Inc., and fees of transfer agents and registrars, but excluding any Selling Expenses. 

“Registration Statement” means any registration statement of the Company filed or to be filed with the Commission under the Securities Act,
including the related prospectus, amendments and supplements to such registration statement, and including pre- and post-effective amendments, and all exhibits and all material incorporated by reference in
such registration statement. 
 “Relative” means, with respect to any natural person: (a) such natural person’s spouse,
(b) any lineal descendant, parent, grandparent, great grandparent or sibling or any lineal descendant of such sibling (in each case whether by blood or legal adoption), and (c) the spouse of a natural person described in clause (b) of
this definition. 
 “Requesting Holder” has the meaning set forth in Section 2.2(a). 

“Requesting Holder and Shelf Piggybacking Holders Securities” has the meaning set forth in Section 2.2(c)(i). 

“Section 2.2 Maximum Number of Shares” has the meaning set forth in Section 2.2(c). 

“Section 2.4 Maximum Number of Shares” has the meaning set forth in Section 2.4(c). 

“Securities Act” means the Securities Act of 1933, as amended, or any successor federal statute, and the rules and regulations of the
Commission thereunder, all as the same shall be in effect at the time. References to any rule under the Securities Act shall be deemed to refer to any similar or successor rule or regulation. 

“Selling Expenses” means all (a) underwriting fees, discounts and selling commissions allocable to the sale of Registrable Securities,
(b) transfer taxes allocable to the sale of the Registrable Securities, (c) costs or expenses related to any roadshows conducted in connection with the marketing of any Shelf Underwritten Offering and (d) fees and expenses of counsel
engaged by any Holders (subject to Article III). 
 “Selling Holder” means a Holder selling Registrable Securities pursuant to a
Registration Statement. 
 “Shares” has the meaning set forth in the recitals. 

“Shelf Piggybacking Holder” has the meaning set forth in Section 2.2(b). 

“Shelf Registration Statement” has the meaning set forth in Section 2.1(a). 

“Shelf Underwritten Offering” has the meaning set forth in Section 2.2(a). 

“Shelf Underwritten Offering Request” has the meaning set forth in Section 2.2(a). 

“Suspension Period” has the meaning set forth in Section 2.3. 

“Transfer” means any offer, sale, pledge, encumbrance, hypothecation, entry into any contract to sell, grant of an option to purchase, short
sale, assignment, transfer, exchange, gift, bequest or other disposition, direct or indirect, in whole or in part, by operation of law or otherwise. “Transfer,” when used as a verb, and “Transferee” and “Transferor”
have correlative meanings. 

 “Underwritten Offering” means an offering (including an offering pursuant to a Shelf
Registration Statement) in which shares of Company Common Stock are sold to an underwriter on a firm commitment basis for reoffering to the public. 

“Underwritten Offering Filing” means (a) with respect to a Shelf Underwritten Offering, a preliminary prospectus supplement (or
prospectus supplement if no preliminary prospectus supplement is used) to the Shelf Registration Statement relating to such Shelf Underwritten Offering, and (b) with respect to a Piggyback Underwritten Offering, (i) a preliminary
prospectus supplement (or prospectus supplement if no preliminary prospectus supplement is used) to an effective shelf Registration Statement (other than the Shelf Registration Statement) in which Registrable Securities could be included and Holders
could be named as selling security holders without the filing of a post-effective amendment thereto (other than a post-effective amendment that becomes effective upon filing) or (ii) a Registration Statement (other than the Shelf Registration
Statement), in each case relating to such Piggyback Underwritten Offering. 
 “WKSI” means a well-known seasoned issuer (as defined in Rule
405 under the Securities Act). 
 ARTICLE II 

REGISTRATION RIGHTS 

Section 2.1 Shelf Registration. 

(a) The Company shall, as soon as practicable after the date hereof, but in any event within three Business Day after the date hereof (or such later date as
mutually agreed by the Company, Double Eagle Energy Holdings III LLC and FourPoint Permian, LLC), file a Registration Statement, or amend an existing shelf registration previously filed by the Company (provided that such amendment becomes effective
upon filing with the Commission) (the “Shelf Registration Statement”), under the Securities Act to permit the public resale of all the Registrable Securities by the Holders from time to time as permitted by Rule 415 under the
Securities Act and shall use commercially reasonable efforts to cause such Registration Statement to become or be declared effective as soon as practicable after the filing thereof, including by filing an automatic shelf registration statement that
becomes effective upon filing with the Commission in accordance with Rule 462(e) under the Securities Act to the extent the Company is then a WKSI. Following the effective date of the Shelf Registration Statement, the Company shall notify the
Holders of the effectiveness of such Registration Statement. 
 (b) The Shelf Registration Statement shall be on Form
S-3 or, if Form S-3 is not then available to the Corporation, on Form S-1 or such other form of registration statement as is then
available to effect a registration for resale of such Registrable Securities and shall contain a prospectus in such form as to permit any Holder to sell such Registrable Securities pursuant to Rule 415 under the Securities Act (or any successor or
similar rule adopted by the Commission then in effect) at any time beginning on the effective date for such Registration Statement. The Shelf Registration Statement shall provide for the resale pursuant to any method or combination of methods
legally available to the Holders and requested by the Majority Holders. 
 (c) The Company shall use commercially reasonable efforts to cause the Shelf
Registration Statement to remain effective, and to be supplemented and amended to the extent necessary to ensure that the Shelf Registration Statement is available or, if not available, that another Registration Statement is available, for the
resale of all the Registrable Securities by the Holders until all of the Registrable Securities have ceased to be Registrable Securities or the earlier termination of this Agreement (as to all Holders) pursuant to
Section 6.1 (the “Effectiveness Period”). 
 (d) When effective, (i) the Shelf Registration Statement
(including the documents incorporated therein by reference) will comply as to form in all material respects with all applicable requirements of the Securities Act and the Exchange Act and will not contain an untrue statement of a material fact or
omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading and (ii) in the case of any prospectus contained in the Shelf Registration Statement, such prospectus will not include any
untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which such statements are made, not misleading. 

 Section 2.2 Underwritten Shelf Offering Requests. 

(a) In the event that any Apollo Holder, Quantum Holder or group of Holders that includes an Apollo Holder or Quantum Holder elects to dispose of Registrable
Securities under a Registration Statement pursuant to an Underwritten Offering and reasonably expects gross proceeds of at least $500 million from such Underwritten Offering (including proceeds attributable to any Registrable Securities
included in such Underwritten Offering by any Shelf Piggybacking Holders), the Company shall, at the request (a “Shelf Underwritten Offering Request”) of such Holder or Holders (in such capacity, a “Requesting
Holder”), enter into an underwriting agreement in a form as is customary in Underwritten Offerings of securities by the Company with the underwriter or underwriters selected pursuant to Section 2.2(d) and shall
take all such other reasonable actions as are requested by the Managing Underwriter of such Underwritten Offering and/or the Requesting Holders in order to expedite or facilitate the disposition of such Registrable Securities and, subject to
Section 2.2(c), the Registrable Securities requested to be included by any Shelf Piggybacking Holder (a “Shelf Underwritten Offering”); provided, however, that the Company shall have no obligation to
facilitate or participate in more than (i) three Shelf Underwritten Offerings during any 12-month period (one on behalf of any Apollo Holders acting as Requesting Holders, one on behalf of any Quantum
Holders acting as Requesting Holders, and one on behalf of either a Quantum Holder or Apollo Holder acting as Requesting Holders, and no more than one Shelf Underwritten Offering in any 90-day period) or
(ii) six Shelf Underwritten Offerings in the aggregate during the term of this Agreement. 
 (b) If the Company receives a Shelf Underwritten Offering
Request, it will give written notice of such proposed Shelf Underwritten Offering to each Holder (other than the Requesting Holder) that, together with such Holder’s Affiliates, holds at least the Minimum Number of Registrable Securities, which
notice shall be held in strict confidence by such Holders and shall include the anticipated filing date of the related Underwritten Offering Filing and, if known, the number of shares of Company Common Stock that are proposed to be included in such
Shelf Underwritten Offering, and of such Holders’ rights under this Section 2.2(b). Such notice shall be given promptly (and in any event at least five Business Days before the filing of the Underwritten Offering
Filing or two Business Days before the filing of the Underwritten Offering Filing in connection with a bought or overnight Underwritten Offering or a Shelf Underwritten Offering Request delivered to the Company within one Business Day of the date of
this Agreement); provided, that if the Shelf Underwritten Offering is a bought or overnight Underwritten Offering and the Managing Underwriter advises the Company and the Requesting Holder that the giving of notice pursuant to this
Section 2.2(b) would adversely affect the offering, no such notice shall be required (and such Holders shall have no right to include Registrable Securities in such bought or overnight Underwritten Offering); and
provided further, that the Company shall not so notify any such other Holder that has notified the Company (and not revoked such notice) requesting that such Holder not receive notice from the Company of any proposed Shelf Underwritten
Offering. Each such Holder shall then have four Business Days (or one Business Day in the case of a bought or overnight Underwritten Offering or a Shelf Underwritten Offering Request delivered to the Company within one Business Day of the date of
this Agreement) after the date on which the Holders received notice pursuant to this Section 2.2(b) to request inclusion of Registrable Securities in the Shelf Underwritten Offering (which request shall specify the maximum
number of Registrable Securities intended to be disposed of by such Holder and such other information as is reasonably required to effect the inclusion of such Registrable Securities) (any such Holder making such request, a “Shelf
Piggybacking Holder”). If no request for inclusion from a Holder is received within such period, such Holder shall have no further right to participate in such Shelf Underwritten Offering. 

(c) If the Managing Underwriter of the Shelf Underwritten Offering shall inform the Company and the Requesting Holders in writing, with a copy to be provided
upon request to any Shelf Piggybacking Holder, of its belief that the number of Registrable Securities requested to be included in such Shelf Underwritten Offering by the Shelf Piggybacking Holders (and any other shares of Company Common Stock
requested to be included by any other Persons having registration rights with respect to such offering), when added to the number of Registrable Securities proposed to be offered by the Requesting Holders, would materially adversely affect such
offering, then the Company shall include in the applicable Underwritten Offering Filing, to the extent of the total number of Registrable Securities that the Company is so advised can be sold in such Shelf Underwritten Offering without so materially
adversely affecting such offering (the “Section 2.2 Maximum Number of Shares”), Registrable Securities in the following priority: 

(i) First, all Registrable Securities that the Requesting Holder and Shelf Piggybacking Holders requested to be included therein (the “Requesting
Holder and Shelf Piggybacking Holders Securities”) (pro rata among the Requesting Holders and Shelf Piggybacking Holders based on the number of Registrable Securities each requested to be included); and 

 (ii) Second, to the extent that the number of Requesting Holder and Shelf Piggybacking Holders Securities is
less than the Section 2.2 Maximum Number of Shares, the shares of Company Common Stock requested to be included by any other Persons having registration rights with respect to such offering, pro rata among such other Persons based on the
number of shares of Company Common Stock each requested to be included. 
 (d) The Company shall propose three or more nationally prominent firms of
investment bankers reasonably acceptable to the Requesting Holders to act as the Managing Underwriter or as other underwriters in connection with such Shelf Underwritten Offering from which the holders of more than 50% of the Registrable Securities
to be so offered shall select the Managing Underwriter and the other underwriters. The Requesting Holders shall determine the pricing of the Registrable Securities offered pursuant to any Shelf Underwritten Offering and the applicable underwriting
discounts and commissions and determine the timing of any such Shelf Underwritten Offering, subject to Section 2.3. 

Section 2.3 Delay and Suspension Rights. Notwithstanding any other provision of this Agreement, the Company may
(a) delay filing or effectiveness of a Shelf Registration Statement (or any amendment thereto) or effecting a Shelf Underwritten Offering or (b) suspend the Holders’ use of any prospectus that is a part of a Shelf Registration
Statement upon written notice to each Holder whose Registrable Securities are included in such Shelf Registration Statement (provided that in no event shall such notice contain any material non-public
information regarding the Company) (in which event such Holder shall discontinue sales of Registrable Securities pursuant to such Registration Statement but may settle any then-contracted sales of Registrable Securities), in each case for a period
of up to 60 days, if the Board determines that (i) such delay or suspension is in the best interest of the Company and its stockholders generally due to a pending financing or other transaction involving the Company, including a proposed sale
of shares of Company Common Stock pursuant to a registration of Company Securities, (ii) such registration or offering would render the Company unable to comply with applicable securities laws or (iii) such registration offering would
require disclosure of material information that the Company has a bona fide business purpose for preserving as confidential (any such period, a “Suspension Period”); provided, however, that in no event shall any
Suspension Periods collectively exceed an aggregate of 120 days in any twelve-month period. For the purposes of calculating the number of days of one or more Suspension Periods under this Section 2.3, such number shall
include any number of days during the applicable period during which the Holders were obligated to discontinue their disposition of Registrable Securities pursuant to Section 2.6(b) of this Agreement. 

Section 2.4 Piggyback Registration Rights. 

(a) Subject to Section 2.4(c), if the Company at any time proposes to file an Underwritten Offering Filing for an Underwritten
Offering of shares of Company Common Stock for its own account or for the account of any other Persons who have or have been granted registration rights (a “Piggyback Underwritten Offering”), it will give written notice of such
Piggyback Underwritten Offering to each Holder that, together with such Holder’s Affiliates, holds at least the Minimum Number of Registrable Securities, which notice shall be held in strict confidence by such Holders and shall include the
anticipated filing date of the Underwritten Offering Filing and, if known, the number of shares of Company Common Stock that are proposed to be included in such Piggyback Underwritten Offering, and of such Holders’ rights under this
Section 2.4(a). Such notice shall be given promptly (and in any event at least five Business Days before the filing of the Underwritten Offering Filing or two Business Days before the filing of the Underwritten Offering
Filing in connection with a bought or overnight Underwritten Offering); provided, that if the Piggyback Underwritten Offering is a bought or overnight Underwritten Offering and the Managing Underwriter advises the Company that the giving of
notice pursuant to this Section 2.4(a) would adversely affect the offering, no such notice shall be required (and such Holders shall have no right to include Registrable Securities in such bought or overnight Underwritten
Offering). Each such Holder shall then have four Business Days (or one Business Day in the case of a bought or overnight Underwritten Offering) after the date on which the Holders received notice pursuant to this
Section 2.4(a) to request inclusion of Registrable Securities in the Piggyback Underwritten Offering (which request shall specify the maximum number of Registrable Securities intended to be disposed of by such Holder and
such other information as is reasonably required to effect the inclusion of such Registrable Securities) (any such Holder making such request, a “Piggybacking Holder”). If no request for inclusion from a Holder is received within
such period, such Holder shall have no further right to participate in such Piggyback Underwritten Offering. Subject to Section 2.4(c), the Company shall use its commercially reasonable efforts to include in the Piggyback
Underwritten Offering all Registrable Securities that the Company has been so requested to include by the Piggybacking Holders; provided, however, that if, at any time after giving written notice of a proposed Piggyback Underwritten Offering
pursuant to this Section 2.4(a) and prior to the execution of an underwriting agreement with respect thereto, the Company or such 

 
other Persons who have or have been granted registration rights, as applicable, shall determine for any reason not to proceed with or to delay such Piggyback Underwritten Offering, the Company
shall give written notice of such determination to the Piggybacking Holders (which such Holders will hold in strict confidence) and (i) in the case of a determination not to proceed, shall be relieved of its obligation to include any
Registrable Securities in such Piggyback Underwritten Offering (but not from any obligation of the Company to pay the Registration Expenses in connection therewith), and (ii) in the case of a determination to delay, shall be permitted to delay
inclusion of any Registrable Securities for the same period as the delay in including the shares of Company Common Stock to be sold for the Company’s account or for the account of such other Persons who have or have been granted registration
rights, as applicable. 
 (b) Each Holder shall have the right to withdraw its request for inclusion of its Registrable Securities in any Piggyback
Underwritten Offering at any time prior to the execution of an underwriting agreement with respect thereto by giving an Opt-Out Notice to the Company requesting that such Holder not receive notice from the
Company of any proposed Piggyback Underwritten Offering; provided, however, that such Holder may later revoke any such Opt-Out Notice in writing. Following receipt of an
Opt-Out Notice from a Holder (unless subsequently revoked), the Company shall not, and shall not be required to, deliver any notice to such Holder pursuant to this Section 2.4 and
such Holder shall no longer be entitled to participate in any Piggyback Underwritten Offering. 
 (c) If the Managing Underwriter of the Piggyback
Underwritten Offering shall inform the Company of its belief that the number of Registrable Securities requested to be included in such Piggyback Underwritten Offering, when added to the number of shares of Company Common Stock proposed to be
offered by the Company or such other Persons who have or have been granted registration rights (and any other shares of Company Common Stock requested to be included by any other Persons having registration rights on parity with the Piggybacking
Holders with respect to such offering), would materially adversely affect such offering, then the Company shall include in such Piggyback Underwritten Offering, to the extent of the total number of securities which the Company is so advised can be
sold in such offering without so materially adversely affecting such offering (the “Section 2.4 Maximum Number of Shares”), shares of Company Common Stock in the following priority: 

(i) First, if the Piggyback Underwritten Offering is for the account of the Company, all shares of Company Common Stock that the Company proposes to include
for its own account (the “Company Securities”); and 
 (ii) Second, if the Piggyback Underwritten Offering is for the account of the
Company, to the extent that the number of Company Securities is less than the Section 2.4 Maximum Number of Shares, or if the Piggyback Underwritten Offering is for the account of any other Persons who have or have been granted registration
rights, the shares of Company Common Stock requested to be included by the Piggybacking Holders and holders of any other shares of Company Common Stock requested to be included by Persons having rights of registration on parity with the Piggybacking
Holders with respect to such offering, pro rata among the Piggybacking Holders and such other holders based on the number of shares of Company Common Stock each requested to be included. 

(d) The Company or other Persons who have or have been granted registration rights, as applicable, shall select the underwriters in any Piggyback Underwritten
Offering and shall determine the pricing of the shares of Company Common Stock offered pursuant to any Piggyback Underwritten Offering, the applicable underwriting discounts and commissions and the timing of any such Piggyback Underwritten Offering.

 Section 2.5 Participation in Underwritten Offerings. 

(a) In connection with any Underwritten Offering contemplated by Sections 2.2 or 2.4, the underwriting agreement into which each Selling Holder and the
Company shall enter into shall contain such representations, covenants, indemnities (subject to Article III) and other rights and obligations as are customary in Underwritten Offerings of securities by the Company; provided that the
Company shall not be required to make any representations or warranties with respect to written information specifically provided by a Selling Holder for inclusion in the applicable Registration Statement. No Selling Holder shall be required to make
any representations or warranties to or agreements with the Company or the underwriters other than representations, warranties or agreements regarding such Selling Holder’s authority to enter into such underwriting agreement and to sell, and
its ownership of and title to, the securities being registered on its behalf, its intended method of distribution and any other representation required by law. 

 (b) Any participation by Holders in a Piggyback Underwritten Offering shall be in accordance with the plan
of distribution of the Company. 
 (c) In connection with any Piggyback Underwritten Offering in which any Holder includes Registrable Securities pursuant
to Section 2.4, such Holder agrees to (i) supply any information reasonably requested by the Company in connection with the preparation of a Registration Statement and/or any other documents relating to such registered
offering and (ii) execute and deliver any agreements and instruments being executed by all holders on substantially the same terms reasonably requested by the Company or the Managing Underwriter, as applicable, to effectuate such registered
offering, including, without limitation, underwriting agreements (subject to Section 2.5(a)), custody agreements, lock-ups, “hold back” agreements pursuant to which such
Holder agrees not to sell or purchase any securities of the Company for the same period of time following the registered offering as is agreed to by the Company and the other participating holders, powers of attorney and questionnaires. 

(d) If the Company or Managing Underwriter, as applicable, requests that the Holders take any of the actions referred to in
Section 2.5(c), the Holders shall take such action promptly but in any event within three Business Days following the date of such request. 

Section 2.6 Registration Procedures. 

(a) In connection with its obligations under this Article II, the Company will: 

(i) promptly prepare and file with the Commission such amendments and supplements to such Registration Statement and the prospectus used in connection
therewith as may be necessary to keep such Registration Statement effective and to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such Registration Statement until such time as all of
such securities have been disposed of in accordance with the intended methods of disposition by the seller or sellers thereof set forth in such Registration Statement; 

(ii) furnish to each Selling Holder such number of conformed copies of such Registration Statement and of each such amendment and supplement thereto (in each
case including without limitation all exhibits), such number of copies of the prospectus contained in such Registration Statement (including without limitation each preliminary prospectus and any summary prospectus) and any other prospectus filed
under Rule 424 under the Securities Act, in conformity with the requirements of the Securities Act, and such other documents, as such seller may reasonably request; 

(iii) if applicable, use commercially reasonable efforts to register or qualify all Registrable Securities and other securities covered by such Registration
Statement under such other securities or blue sky laws of such jurisdictions as each Selling Holder thereof shall reasonably request, to keep such registration or qualification in effect for so long as such Registration Statement remains in effect,
and to take any other action which may be reasonably necessary or advisable to enable such seller to consummate the disposition in such jurisdictions of the securities owned by such seller, except that the Company shall not for any such purpose be
required to qualify generally to do business as a foreign corporation in any jurisdiction wherein it would not but for the requirements of this clause (iii) be obligated to be so qualified or to consent to general service of process in
any such jurisdiction; 
 (iv) in connection with an Underwritten Offering, use all commercially reasonable efforts to provide to each Selling Holder a copy
of any auditor “comfort” letters, customary legal opinions or reports of the independent petroleum engineers of the Company relating to the oil and gas reserves of the Company, in each case that have been provided to the Managing
Underwriter in connection with the Underwritten Offering; 
 (v) promptly notify each Selling Holder, at any time when a prospectus relating thereto is
required to be delivered under the Securities Act, upon discovery that, or upon the happening of any event as a result of which, the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material
fact or omits to state any material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading, and at the request of any such seller promptly prepare and furnish to such
seller a reasonable number of copies of a supplement to or an amendment of such prospectus as may be necessary so that, as thereafter delivered to the purchasers of such securities, such prospectus shall not include an untrue statement of a material
fact or omit to state a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading; 

 (vi) otherwise use its commercially reasonable efforts to comply with all applicable rules and regulations
of the Commission, and make available to its security holders, as soon as reasonably practicable, an earnings statement, which earnings statement shall satisfy the provisions of Section 11(a) of the Securities Act, and shall furnish to each
such Selling Holder at least the Business Day prior to the filing thereof a copy of any amendment or supplement to such Registration Statement or prospectus; 

(vii) provide and cause to be maintained a transfer agent and registrar for all Registrable Securities covered by such Registration Statement from and after a
date not later than the effective date of such Registration Statement; 
 (viii) cause all Registrable Securities covered by such Registration Statement to
be listed on any securities exchange on which the Company Common Stock is then listed; 
 (ix) enter into such customary agreements and take such other
actions as the Selling Holder or Selling Holders shall reasonably request in order to expedite or facilitate the disposition of such Registrable Securities (including, in the case of a Shelf Underwritten Offering or Piggyback Underwritten Offering,
to agree, and to cause its directors and “executive officers” (as defined under Section 16 of the Exchange Act) to agree, to such “lock-up” arrangements for up to 30 days with the
underwriters thereof to the extent reasonably requested by the Managing Underwriters, subject to exceptions for permitted sales by directors and executive officers during such period consistent with underwritten offerings previously conducted by the
Company); and 
 (x) until the six month anniversary of the date of this Agreement, in connection with any transaction or series of anticipated transactions
(a) effected pursuant to the Shelf Registration Statement, (b) with reasonably anticipated gross proceeds in excess of $50 million or involving Registrable Securities having a fair market value in excess of $50 million and
(c) involving a broker, agent, counterparty, underwriter, bank or other financial institution (“Financial Counterparty”), to the extent reasonably requested by the Financial Counterparty in order to engage in the proposed
transaction, the Company will use its commercially reasonable efforts to cooperate with such Holder in allowing the Financial Counterparty to conduct customary “underwriter’s due diligence” with respect to the Company. 

(b) Each Holder agrees by acquisition of such Registrable Securities that upon receipt of any notice from the Company of the happening of any event of the
kind described in Section 2.6(a)(v), such Holder will forthwith discontinue such Holder’s disposition of Registrable Securities pursuant to the Registration Statement until such Holder’s receipt of the copies of
the supplemented or amended prospectus contemplated by Section 2.6(a)(v) as filed with the Commission or until it is advised in writing by the Company that the use of such Registration Statement may be resumed, and, if so
directed by the Company, will deliver to the Company (at the Company’s expense) all copies, other than permanent file copies, then in such Holder’s possession of the prospectus relating to such Registrable Securities current at the time of
receipt of such notice. The Company may provide appropriate stop orders to enforce the provisions of this Section 2.6(b). 

Section 2.7 Cooperation by Holders. The Company shall have no obligation to include Registrable Securities of a Holder
in any Registration Statement or Underwritten Offering if such Holder has failed to timely furnish such information that the Company determines, after consultation with its counsel, is reasonably required in order for any registration statement or
prospectus supplement, as applicable, to comply with the Securities Act. 
 Section 2.8 Restrictions on Public Sale by
Holders. Each Holder agrees, following the six-month anniversary of the date of this Agreement, not to effect any public sale or distribution of Registrable Securities for a period of up to 30 days
following completion of an Underwritten Offering of equity securities for the account of the Company; provided that (a) the Company gives written notice to such Holder of the date of the commencement and termination of such period with
respect to any such Underwritten Offering and (b) the duration of the foregoing restrictions shall be no longer than the duration of the shortest restriction generally imposed by the underwriters of such public sale or distribution on the
Company or on the officers or directors or any other shareholder of the Company on whom a restriction is imposed; provided further, that this Section 2.8 shall not apply to any Holder that (a) together with such
Holder’s Affiliates, holds less than 10% of the Company’s outstanding Company Common Stock or (b) has delivered (and not revoked) an Opt-Out Notice to the Company. 

 Section 2.9 Expenses. The Company shall be responsible for all
Registration Expenses incident to its performance of or compliance with its obligations under this Article II. Each Selling Holder shall pay its pro rata share of all Selling Expenses in connection with any sale of its Registrable Securities
hereunder. 
 Section 2.10 Other Registration Rights. From and after the date hereof, the Company shall not, without
the prior written consent of the Majority Holders, enter into any agreement with any current or future holder of any securities of the Company that would allow such current or future holder to require the Company to include securities in any
registration statement filed by the Company for such Holders on a basis other than pari passu with, or expressly subordinate to, the piggyback rights of the Holders hereunder; provided, that in no event shall the Company enter into any
agreement that would permit another holder of securities of the Company to participate on a pari passu basis (in terms of priority of cut-back based on advice of underwriters) with a Requesting Holder
in a Shelf Underwritten Offering. 
 Section 2.11 Opt-Out Notices. Any
Holder may deliver written notice (an “Opt-Out Notice”) to the Company requesting that such Holder not receive notice from the Company of the proposed filing of any Shelf Underwritten
Offering, Piggyback Underwritten Offering, the withdrawal of any Shelf Underwritten Offering or Piggyback Underwritten Offering or any event that would lead to a Suspension Period as contemplated by Section 2.3; provided, however, that such
Holder may later revoke any such Opt-Out Notice in writing. Following receipt of an Opt-Out Notice from a Holder (unless subsequently revoked), the Company shall not
deliver any notice to such Holder pursuant to Section 2.2, Section 2.3, Section 2.4, or Section 2.6, as applicable, and such Holder shall no longer be entitled to the rights associated with any such notice and each time prior to
a Holder’s intended use of an effective Registration Statement, such Holder will notify the Company in writing at least two Business Days in advance of such intended use, and if a notice of a Suspension Period was previously delivered (or would
have been delivered but for the provisions of this Section 2.11) and the Suspension Period remains in effect, the Company will so notify such Holder, within one Business Day of such Holder’s notification to the
Company, by delivering to such Holder a copy of such previous notice of such Suspension Period, and thereafter will provide such Holder with the related notice of the conclusion of such Suspension Period immediately upon its availability. 

ARTICLE III 

INDEMNIFICATION AND CONTRIBUTION 

Section 3.1 Indemnification by the Company. The Company will indemnify and hold harmless each Selling Holder, its
officers and directors and each Person (if any) that controls such Holder within the meaning of either Section 15 of the Securities Act or Section 20 of the Exchange Act from and against any and all losses, claims, damages, liabilities,
costs and expenses (including attorneys’ fees) (“Losses”) caused by, arising out of, resulting from or related to any untrue statement or alleged untrue statement of a material fact (a) contained in any Registration
Statement relating to the Registrable Securities (as amended or supplemented if the Company shall have furnished any amendments or supplements thereto), or any omission or alleged omission to state therein a material fact required to be stated
therein or necessary to make the statements therein not misleading or (b) included in any prospectus relating to the Registrable Securities (as amended or supplemented if the Company shall have furnished any amendments or supplements thereto)
or any preliminary prospectus, or any omission or alleged omission to state therein a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading, provided,
however, that such indemnity shall not apply to that portion of such Losses caused by, or arising out of, any untrue statement, or alleged untrue statement or any such omission or alleged omission, to the extent such statement or omission was
made in reliance upon and in conformity with information furnished in writing to the Company by or on behalf of such Holder expressly for use therein. 

Section 3.2 Indemnification by the Holders. Each Holder agrees to indemnify and hold harmless the Company, its
officers and directors and each Person (if any) that controls the Company within the meaning of either Section 15 of the Securities Act or Section 20 of the Exchange Act from and against any and all Losses caused by, arising out of,
resulting from or related to any untrue statement or alleged untrue statement of a material fact (a) contained in any Registration Statement relating to Registrable Securities (as amended or supplemented if the Company shall have furnished any
amendments or supplements thereto), or any omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein not misleading or (b) included in any prospectus relating to the
Registrable Securities (as amended or supplemented if the Company shall have furnished any amendments or supplements thereto) or any preliminary prospectus, or any omission or alleged omission to state therein a material fact necessary in order to
make the statements therein, in the light of the circumstances under which 

 
they were made, not misleading, only to the extent such statement or omission was made in reliance upon and in conformity with information furnished in writing by or on behalf of such Holder
expressly for use in any Registration Statement or prospectus relating to the Registrable Securities, or any amendment or supplement thereto, or any preliminary prospectus. 

Section 3.3 Indemnification Procedures. In case any proceeding (including any governmental investigation) shall be
instituted involving any Person in respect of which indemnity may be sought pursuant to Section 3.1 or 3.2, such Person (the “Indemnified Party”) shall promptly notify the Person against whom such
indemnity may be sought (the “Indemnifying Party”) in writing (provided that the failure of the Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Article
III, except to the extent the Indemnifying Party is actually prejudiced by such failure to give notice), and the Indemnifying Party shall be entitled to participate in such proceeding and, unless in the reasonable opinion of outside counsel to
the Indemnified Party a conflict of interest between the Indemnified Party and Indemnifying Party may exist in respect of such claim, to assume the defense thereof jointly with any other Indemnifying Party similarly notified, to the extent that it
chooses, with counsel reasonably satisfactory to such Indemnified Party, and after notice from the Indemnifying Party to such Indemnified Party that it so chooses, the Indemnifying Party shall not be liable to such Indemnified Party for any legal or
other expenses subsequently incurred by such Indemnified Party in connection with the defense thereof other than reasonable costs of investigation; provided, however, that (a) if the Indemnifying Party fails to assume the defense or employ
counsel reasonably satisfactory to the Indemnified Party, (b) if such Indemnified Party who is a defendant in any action or proceeding which is also brought against the Indemnifying Party reasonably shall have concluded that there may be one or
more legal defenses available to such Indemnified Party which are not available to the Indemnifying Party or (c) if representation of both parties by the same counsel is otherwise inappropriate under applicable standards of professional conduct
then, in any such case, the Indemnified Party shall have the right to assume or continue its own defense as set forth above (but with no more than one firm of counsel for all Indemnified Parties in each jurisdiction, except to the extent any
Indemnified Party or Parties reasonably shall have concluded that there may be legal defenses available to such party or parties which are not available to the other Indemnified Parties or to the extent representation of all Indemnified Parties by
the same counsel is otherwise inappropriate under applicable standards of professional conduct) and the Indemnifying Party shall be liable for any expenses therefor. No Indemnifying Party shall, without the written consent of the Indemnified Party,
effect the settlement or compromise of, or consent to the entry of any judgment with respect to, any pending or threatened action or claim in respect of which indemnification or contribution may be sought hereunder (whether or not the Indemnified
Party is an actual or potential party to such action or claim) unless such settlement, compromise or judgment (i) includes an unconditional release of the Indemnified Party from all liability arising out of such action or claim and
(ii) does not include a statement as to, or an admission of, fault, culpability or a failure to act, by or on behalf of any Indemnified Party. 

Section 3.4 Contribution. 

(a) If the indemnification provided for in this Article III is unavailable to an Indemnified Party in respect of any losses, claims, damages or
liabilities in respect of which indemnity is to be provided hereunder, then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall to the fullest extent permitted by law contribute to the amount paid or payable by such
Indemnified Party as a result of such losses, claims, damages or liabilities in such proportion as is appropriate to reflect the relative fault of such party in connection with the statements or omissions that resulted in such losses, claims,
damages or liabilities, as well as any other relevant equitable considerations. The relative fault of the Company (on the one hand) and a Holder (on the other hand) shall be determined by reference to, among other things, whether the untrue or
alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to information supplied by such party and the parties’ relative intent, knowledge, access to information and opportunity to correct
or prevent such statement or omission. 
 (b) The Company and each Holder agree that it would not be just and equitable if contribution pursuant to this
Article III were determined by pro rata allocation or by any other method of allocation that does not take account of the equitable considerations referred to in Section 3.4(a). The amount paid or payable by an
Indemnified Party as a result of the losses, claims, damages or liabilities referred to in Section 3.4(a) shall be deemed to include, subject to the limitations set forth above, any legal or other expenses reasonably
incurred by such Indemnified Party in connection with investigating or defending any such action or claim. Notwithstanding the provisions of this Article III, no Holder shall be liable for indemnification or contribution pursuant to this
Article III for any amount in excess of the net proceeds of the offering received by such Holder, less the amount of any damages which such Holder has otherwise 

 
been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. 

ARTICLE IV 
 RULE 144

 With a view to making available the benefits of certain rules and regulations of the Commission that may permit the resale of the Registrable
Securities without registration, the Company agrees to use its commercially reasonable efforts to: 
 (a) make and keep public information regarding the
Company available, as those terms are understood and defined in Rule 144 under the Securities Act, at all times from and after the date hereof; 
 (b) file
with the Commission in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act at all times from and after the date hereof; and 

(c) so long as a Holder owns any Registrable Securities, furnish (i) to the extent accurate, forthwith upon request, a written statement of the Company
that it has complied with the reporting requirements of Rule 144 under the Securities Act and (ii) unless otherwise available via the Commission’s EDGAR filing system, to such Holder forthwith upon request a copy of the most recent annual
or quarterly report of the Company, and such other reports and documents so filed as such Holder may reasonably request in availing itself of any rule or regulation of the Commission allowing such Holder to sell any such securities without
registration. 
 ARTICLE V 

LEGENDS AND TRANSFER OF RIGHTS 

Section 5.1 Share Legend. 

(a) Each certificate or book-entry notation representing the Shares shall (unless otherwise permitted by the provisions of
Section 5.1(b)) bear a legend in substantially the following form: 
 THESE SHARES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER ANY OTHER SECURITIES LAWS AND MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED, ASSIGNED, HYPOTHETICATED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF (I) AN EFFECTIVE REGISTRATION OF THE
SHARES UNDER THE SECURITIES ACT AND OTHER APPLICABLE SECURITIES LAWS, OR (II) AN OPINION OF COUNSEL, IN SUCH FORM AND BY SUCH COUNSEL SATISFACTORY TO PIONEER NATURAL RESOURCES COMPANY AND ITS COUNSEL, THAT SUCH OFFER, SALE, TRANSFER,
ASSIGNMENT, HYPOTHECATION OR OTHER DISPOSITION IS EXEMPT FROM REGISTRATION AND THE PROSPECTUS DELIVERY REQUIREMENTS OF THE SECURITIES ACT AND OF ANY APPLICABLE SECURITIES LAWS. 

(b) The legend on any shares of Company Common Stock covered by this Agreement shall be removed if (i) such shares of Company Common Stock are sold
pursuant to an effective registration statement, (ii) a registration statement covering the resale of such shares of Company Common Stock is effective under the Securities Act and the applicable holder of such share of Company Common Stock
delivers to the Company a representation letter agreeing that such shares of Company Common Stock will be sold under such effective registration statement, (iii) if such shares of Company Common Stock may be sold by the holder thereof free of
restrictions pursuant to Rule 144(b) under the Securities Act or (iv) such shares of Company Common Stock are being sold, assigned or otherwise transferred pursuant to Rule 144 under the Securities Act; provided, that with respect to
clause (iii) or (iv) above, the holder of such shares of Company Common Stock has provided all necessary documentation and evidence (which may include an opinion of counsel) as may reasonably be required by the Company to confirm that the
legend may be removed under applicable securities law. The Company shall cooperate with the applicable holder of Company Common Stock covered by this Agreement to effect removal of the legend on such shares pursuant to this
Section 5.1(b) as soon as reasonably practicable after delivery of notice from such holder that the conditions to removal are satisfied (together with any documentation required to be delivered by such holder pursuant to
the immediately preceding sentence). The Company shall bear all direct costs and expenses associated with the removal of a legend pursuant to this Section 5.1(b); provided, that the applicable holder shall be
responsible for all legal fees and expenses of counsel incurred by such holder with respect to delivering the legal opinion to the Company. 

 Section 5.2 Transfer of Rights. The rights to registration and other
rights under this Agreement may be assigned to a Transferee of Registrable Securities if (a) such Transferee is a Permitted Transferee or (b) such Transferee is acquiring at least 500,000 Registrable Securities and such Transferee has
delivered to the Company a duly executed Adoption Agreement. 
 ARTICLE VI 

MISCELLANEOUS 

Section 6.1 Termination. This Agreement shall terminate, and the parties shall have no further rights or obligations
hereunder on (a) the fifth anniversary of the date hereof or (b) as to any Holder, on such earlier date on which both (i) such Holder, together with such Holder’s Affiliates, owns less than 1,000,000 Registrable Securities and
(ii) all Registrable Securities owned by such Holder and such Holder’s Affiliates may be sold without restriction pursuant to Rule 144 under the Securities Act. 

Section 6.2 Severability. If any provision of this Agreement shall be determined to be illegal and unenforceable by
any court of law, the remaining provisions shall be severable and enforceable in accordance with their terms. 
 Section 6.3
Governing Law; Waiver of Jury Trial. 
 (a) This Agreement shall be governed by and construed in accordance with the laws of the State of
Delaware, without regard to principles of conflicts of laws that would direct the application of the laws of another jurisdiction. 
 (b) THE PARTIES HEREBY
WAIVE TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM BROUGHT BY ANY PARTY AGAINST ANOTHER IN ANY MATTER WHATSOEVER ARISING OUT OF OR IN RELATION TO OR IN CONNECTION WITH THIS AGREEMENT. FURTHER, NOTHING HEREIN SHALL DIVEST A COURT OF
COMPETENT JURISDICTION OF THE RIGHT AND POWER TO GRANT A TEMPORARY RESTRAINING ORDER, TO GRANT TEMPORARY INJUNCTIVE RELIEF, OR TO COMPEL SPECIFIC PERFORMANCE OF ANY DECISION OF AN ARBITRAL TRIBUNAL MADE PURSUANT TO THIS PROVISION. 

Section 6.4 Adjustments Affecting Registrable Securities. The provisions of this Agreement shall apply to any and all
shares of capital stock of the Company or any successor or assignee of the Company (whether by merger, consolidation, sale of assets or otherwise) which may be issued in respect of, in exchange for or in substitution for Registrable Securities, by
reason of any stock dividend, split, reverse split, combination, recapitalization, reclassification, merger, consolidation or otherwise in such a manner and with such appropriate adjustments as to reflect the intent and meaning of the provisions
hereof and so that the rights, privileges, duties and obligations hereunder shall continue with respect to the capital stock of the Company as so changed. 

Section 6.5 Binding Effects; Benefits of Agreement. This Agreement shall be binding upon and inure to the benefit of
the Company and its successors and assigns and each Holder and its successors and assigns. Except as provided in Section 5.2, neither this Agreement nor any of the rights, benefits or obligations hereunder may be assigned
or transferred, by operation of law or otherwise, by any Holder without the prior written consent of the Company. 
 Section 6.6
Notices. All notices or other communications which are required or permitted hereunder shall be in writing and shall be deemed to have been given if (a) personally delivered, (b) sent by nationally recognized overnight
courier, (c) sent by registered or certified mail, postage prepaid, return receipt requested, or (d) sent by email. Such notices and other communications must be sent to the following addresses or email addresses: 

(a) If to the Company, to: 
 Pioneer Natural Resources Company

 777 Hidden Ridge 
 Irving, Texas 75038

 
Attention: Mark H. Kleinman 
 Email: mark.kleinman@pxd.com 

with copies (which shall not constitute notice) to: 
 Gibson,
Dunn & Crutcher LLP 
 811 Main Street, Suite 3000 

Houston, Texas 77002 
 Attention: Michael P. Darden; Jeffery A.
Chapman 
 Email: MPDarden@gibsondunn.com; JChapman@gibsondunn.com 

(b) If to an Initial Holder, to the address or email address of such Initial Holder as they appear on such Initial Holder’s signature page attached
hereto or such other address or email address as may be designated in writing by such Holder; and 
 (c) If to any other Holders, to their respective
addresses or email addresses set forth on the applicable Adoption Agreement; 
 or to such other address or email address as the party to whom notice is to
be given may have furnished to such other party in writing in accordance herewith. Any such communication shall be deemed to have been received (a) when delivered, if personally delivered, (b) the next Business Day after delivery, if sent
by nationally recognized, overnight courier, (c) on the third Business Day following the date on which the piece of mail containing such communication is posted, if sent by first-class mail or (d) on the date sent, if sent by email during
normal business hours of the recipient or on the next Business Day, if sent by email after normal business hours of the recipient. 

Section 6.7 Modification; Waiver. This Agreement may be amended, modified or supplemented only by a written instrument
duly executed by the Company and the Majority Holders, provided, however, that this Agreement may not be amended, modified or supplemented in a manner that is disproportionately adverse to the rights of a Holder under this Agreement as compared to
the other Holders without the prior written consent of such Holder. No course of dealing between the Company and the Holders (or any of them) or any delay in exercising any rights hereunder will operate as a waiver of any rights of any party to this
Agreement. The failure of any party to enforce any of the provisions of this Agreement will in no way be construed as a waiver of such provisions and will not affect the right of such party thereafter to enforce each and every provision of this
Agreement in accordance with its terms. 
 Section 6.8 Entire Agreement. Except as otherwise expressly provided
herein, this Agreement constitutes the entire agreement among the parties pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements and understandings of the parties in connection therewith. 

Section 6.9 Counterparts. This Agreement may be executed in any number of counterparts, and each such counterpart
shall be deemed to be an original instrument, but all such counterparts taken together shall constitute but one agreement. 

[signature page follows] 

 IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be executed by its undersigned duly
authorized representative as of the date first written above. 
  

			
	PIONEER NATURAL RESOURCES COMPANY
		
	By:	 	 /s/ Mark H. Kleinman

	Name:	 	Mark H. Kleinman
	Title:	 	Executive Vice President and General Counsel

 SIGNATURE PAGE TO REGISTRATION
RIGHTS AGREEMENT 
  
 [Additional Signature
Pages Have Been Intentionally Omitted] 

 EXHIBIT A 

ADOPTION AGREEMENT 
 This Adoption
Agreement (“Adoption Agreement”) is executed by the undersigned transferee (“Transferee”) pursuant to the terms of the Registration Rights Agreement, dated as of May 4, 2021, among Pioneer Natural Resources
Company, a Delaware corporation (the “Company”), and the Holders party thereto (as amended from time to time, the “Registration Rights Agreement”). Terms used and not otherwise defined in this Adoption Agreement
have the meanings set forth in the Registration Rights Agreement. 
 By the execution of this Adoption Agreement, the Transferee agrees as follows: 

1. Acknowledgement. Transferee acknowledges that Transferee is acquiring certain shares of Company Common Stock subject to the terms and conditions of
Registration Rights Agreement, among the Company and the Holders party thereto. 
 2. Agreement. Transferee (a) agrees that the shares of
Company Common Stock acquired by Transferee shall be bound by and subject to the terms of the Registration Rights Agreement, pursuant to the terms thereof, and (b) hereby adopts the Registration Rights Agreement with the same force and effect
as if he, she or it were originally a party thereto. 
 3. Notice. Any notice required as permitted by the Registration Rights Agreement shall be
given to Transferee at the address listed below Transferee’s signature. 
 4. Joinder. The spouse of the undersigned Transferee, if applicable,
executes this Adoption Agreement to acknowledge its fairness and that it is in such spouse’s best interest, and to bind such spouse’s community interest, if any, in the shares of Company Common Stock and other securities referred to above
and in the Registration Rights Agreement, to the terms of the Registration Rights Agreement. 
  

	
	 Signature:

	          

	          

 Address: 
 Contact Person: 

Telephone Number: 
 Email:Exhibit 10.1

 

APTOSE BIOSCIENCES INC.

 

CONSULTING AGREEMENT

 

This Consulting Agreement (“Agreement”)
is entered into as of March 26, 2021 (the “Effective Date”) by and between Aptose Biosciences Inc. (the “Company”)
and the individual or entity named in the signature page hereto (“Consultant”). The Company desires to retain
Consultant as an independent contractor to perform consulting services for the Company, and Consultant is willing to perform such
services, on the terms described below. In consideration of the mutual promises contained herein, the parties agree as follows:

 

1.     Services and Compensation.
Consultant agrees to perform for the Company the services described in Exhibit A (the “Services”),
and the Company agrees to pay Consultant the compensation described in Exhibit A in exchange for Consultant’s
performance of the Services.

 

2.     Confidentiality.

 

A.           
Definition. “Confidential Information” means any non-public information that relates to the actual or
anticipated business or research and development of the Company, including, but not limited to, the Company’s technical data
and trade secrets. Specifically, Confidential Information includes, but is not limited to, business plans, research, product plans
and other non-public information regarding Company’s products, services, and markets, customer lists and customers (including,
but not limited to, those customers of the Company on whom Consultant may call or with whom Consultant may become acquainted during
the term of this Agreement), software, developments, inventions, processes, formulas, technology, designs, drawing, engineering,
specifications, hardware configuration information, marketing, prices, finances or other business information; provided, however,
Confidential Information does not include information that (i) is known to Consultant at the time of disclosure to Consultant
by the Company as evidenced by written records of Consultant, (ii) has become publicly known and made generally available
through no wrongful act of Consultant, (iii) has been rightfully received by Consultant from a third party who is authorized
to make such disclosure, or (iv) is independently developed by Consultant without any use of the Confidential Information as evidenced
by written records of Consultant.

 

B.    Nonuse and Nondisclosure.
Consultant will not, during or subsequent to the term of this Agreement, (i) use the Confidential Information for any purpose
whatsoever other than the performance of the Services on behalf of the Company or (ii) disclose the Confidential Information
to any third party. Consultant agrees that all Confidential Information will remain the sole property of the Company. Consultant
also agrees to take all reasonable precautions to prevent any unauthorized disclosure of such Confidential Information.

 

C.    Former Client Confidential
Information. Consultant agrees that Consultant will not, during the term of this Agreement, improperly use or disclose any
proprietary information or trade secrets of any former or current employer or client of Consultant or other person or entity with
which Consultant has an agreement or duty to keep in confidence such information acquired by Consultant, if any. Consultant also
agrees that Consultant will not bring onto the Company’s premises any unpublished document, trade secrets, or proprietary
information belonging to any such employer, person or entity unless consented to in writing by such employer, person or entity.

 

D.    Third Party Confidential
Information. Consultant acknowledges that the Company has received and in the future may receive from third parties confidential
or proprietary information subject to a duty on the Company’s part to maintain the confidentiality of such information and
to use it only for certain limited purposes. Consultant agrees that, during the term of this Agreement and thereafter, Consultant
owes the Company and such third parties a duty to hold all such confidential or proprietary information in the strictest confidence
and not to disclose it to any person, firm or corporation or to use it except as necessary in carrying out the Services for the
Company consistent with the Company’s agreement with such third party.

 

    
	 	- 1 -	 

     

    

 

E.    Return of Materials.
Upon the termination of this Agreement, or upon Company’s earlier request, Consultant will deliver to the Company all of
the Company’s property, including but not limited to all electronically stored information and passwords to access such property,
or Confidential Information that Consultant may have in Consultant’s possession or control.

 

F.    Immunity From Liability
for Certain Confidential Disclosures. Consultant acknowledges, agrees, and understands that (i) nothing in this Agreement prohibits
Consultant from reporting to any governmental authority or attorney information concerning suspected violations of law or regulation,
provided that Consultant does so consistent with 18 U.S.C. 1833, and (ii) Consultant may disclose trade secret information
to a government official or to an attorney and use it in certain court proceedings without fear of prosecution or liability, provided
that Consultant does so consistent with 18 U.S.C. 1833. In addition, nothing in this Agreement prohibits or restricts Consultant
(or Consultant’s attorney) from filing a charge or complaint with the Securities and Exchange Commission, the Financial Industry
Regulatory Authority, any other securities regulatory agency or authority, the Occupational Safety and Health Administration, or
any other federal or state regulatory authority (“Government Agencies”). Consultant further understands that
this Agreement does not limit the Consultant’s ability to communicate with any Government Agencies or otherwise participate
in any investigation or proceeding that may be conducted by any Government Agency without notice to the Company. This Agreement
does not limit the Consultant’s right to receive an award for information provided to any Government Agencies.

 

3.     Ownership.

 

A.    Assignment. Consultant
agrees that all copyrightable material, notes, records, drawings, designs, inventions, improvements, developments, discoveries
and trade secrets conceived, discovered, developed or reduced to practice by Consultant during the term of this Agreement, solely
or in collaboration with others, that relate in any manner to any Services to be performed by Consultant under this Agreement (collectively,
“Inventions”), are the sole property of the Company as between Consultant and Company. All Inventions that Consultant
conceives, reduces to practice, develops or has developed (in whole or in part, either alone or jointly with others) shall be the
sole property of the Company and its assigns to the maximum extent permitted by law (and to the fullest extent permitted by law
shall be deemed “works made for hire”). Consultant also agrees to irrevocably assign (or cause to be irrevocably assigned)
and hereby irrevocably assigns to the Company all right, title and interest in all Inventions and any copyrights, patents, trademarks,
trade secrets, mask work rights, moral rights and intellectual property and other rights (“Intellectual Property Rights”)
relating to all Inventions.

 

B.    Further Assurances.
Consultant shall take steps that may be necessary to assist Company, or its designee, at the Company’s expense, in every
proper way to complete the transfer of and secure the Company’s rights in the Inventions and Intellectual Property Rights
in any and all countries, including by making the disclosure to the Company of all pertinent information and data with respect
to all Inventions, and executing all applications, specifications, oaths, assignments and all other instruments that the Company
may deem necessary in order to apply for and obtain such rights and in order to assign and convey to the Company, its successors,
assigns and nominees the sole and exclusive right, title and interest in and to all Inventions, and any copyrights, patents, mask
work rights or other intellectual property rights relating to all Inventions. Consultant also agrees that Consultant’s obligation
to execute or cause to be executed any such instrument or papers shall continue after the termination of this Agreement.

 

    
	 	- 2 -	 

     

    

 

C.    Pre-Existing Materials.
Subject to Section 3A, Consultant agrees that if, in the course of performing the Services, Consultant incorporates
into any Invention developed under this Agreement any pre-existing invention, improvement, development, concept, discovery or other
proprietary information owned by Consultant or in which Consultant has an interest, (i) Consultant will inform Company, in
writing before incorporating such invention, improvement, development, concept, discovery or other proprietary information into
any Invention, and (ii) the Company is hereby granted a nonexclusive, royalty-free, perpetual, irrevocable, worldwide license
to make, have made, modify, use and sell such item as part of or in connection with such Invention. Consultant will not incorporate
knowingly any invention, improvement, development, concept, discovery or other proprietary information owned by any third party
into any Invention without Company’s prior written permission.

 

D.    Attorney-in-Fact.
Consultant agrees that, if the Company is unable because of Consultant’s unavailability, dissolution, mental or physical
incapacity, or for any other reason, to secure Consultant’s signature for the purpose of applying for or pursuing any application
for any United States or foreign patents or mask work or copyright registrations covering the Inventions assigned to the Company
in Section 3A, then Consultant hereby irrevocably designates and appoints the Company and its duly authorized officers
and agents as Consultant’s agent and attorney-in-fact, to act for and on Consultant’s behalf to execute and file any
such applications and to do all other lawfully permitted acts to further the prosecution and issuance of patents, copyright and
mask work registrations with the same legal force and effect as if executed by Consultant.

 

4.     Conflicting Obligations.

 

A.    Conflicts. Consultant
certifies that Consultant has no outstanding agreement or obligation that is in conflict with any of the provisions of this Agreement
or that would preclude Consultant from complying with the provisions of this Agreement. Consultant will not enter into any such
conflicting agreement during the term of this Agreement. Consultant’s violation of this Section 4A will be considered
a material breach under Section 6.B.

 

B.    
Third-Party Services. Notwithstanding the foregoing, the Company hereby acknowledges and agrees that Consultant has taken
a full-time employment position with another company (the “Third Party Company”), and that Consultant’s services
for such Third Party Company shall in no way conflict with Consultant’s duties hereunder, nor shall Consultant or the Third
Party Company be liable hereunder with respect to Consultant’s services for the Third Party Company. The Third Party Company
is an intended third-party beneficiary of this Section 4.B. If any work requested by the Company to be performed under this
Agreement may reasonably relate to any ongoing internal research program of, or conflict with any obligations to, the Third Party
Company, then Consultant shall so notify the Company’s Chief Executive Officer and in such case, Consultant shall not be
required to perform such work. Any such notice by Consultant shall be summary in nature and shall not include any confidential
or proprietary information of the Third Party Company. Consultant certifies that all work performed under this Agreement during
the term of this Agreement will be performed on Consultant’s own time outside of Consultant’s current employment with
the Third Party Company and without using any of Third Party Company’s equipment, supplies, facilities or confidential information.
Consultant agrees that, during the term of this Agreement, Consultant will use his commercially reasonable efforts to segregate
the Services performed under this Agreement from Consultant’s work done for the Third Party Company.

 

    
	 	- 3 -	 

     

    

 

5.     Reports. Consultant
also agrees that Consultant will, from time to time during the term of this Agreement or any extension thereof, keep the Company
advised as to Consultant’s progress in performing the Services under this Agreement. Consultant further agrees that Consultant
will, as requested by the Company, prepare written reports with respect to such progress. The Company and Consultant agree that
the time required to prepare such written reports will be considered time devoted to the performance of the Services.

 

6.     Term and Termination.

 

A.    Term. The term
of this Agreement will begin on the Effective Date and will continue until the earlier of (i) final completion of the Services,
on March 26, 2022, or (ii) termination as provided in Section 6B.

 

B.    Termination. Either
party may terminate this Agreement upon 14 days’ prior written notice of such termination pursuant to Section 11F
of this Agreement. In addition, the Company may terminate this Agreement immediately and without prior notice if Consultant refuses
to or is unable to perform the Services or is in breach of any material provision of this Agreement. Consultant may terminate this
Agreement immediately and without prior notice if the Company is in breach of any material provision of this Agreement, including
but not limited to, providing payment and/or consideration in the agreed-upon manner.

 

C.    Survival. Upon
termination of this Agreement, all rights and duties of the Company and Consultant toward each other shall cease except:

 

(i)           
The Company will pay, within 30 days after the effective date of termination, all amounts owing to Consultant for Services completed
and accepted by the Company prior to the termination date and related expenses, if any, submitted in accordance with the Company’s
policies and in accordance with the provisions of Section 1 of this Agreement; and

 

(ii)          
Section 2 (Confidentiality), Section 3 (Ownership), Section 4 (Conflicting Obligations), Section 7
(Independent Contractor; Benefits), Section 8 (Indemnification), Section 9 (Nonsolicitation) and Section 10
(Arbitration and Equitable Relief) will survive termination of this Agreement.

 

7.     Independent Contractor;
Benefits.

 

A.    Independent Contractor.
It is the express intention of the Company and Consultant that Consultant perform the Services as an independent contractor
to the Company. Consultant represents that Consultant has the qualifications and ability to perform the Services in a professional
manner, without the advice, control, or supervision of Company. Consultant shall be solely responsible for the professional performance
of the Services, and shall receive no assistance, direction, or control from Company. Consultant shall have sole discretion and
control of Consultant’s services and the manner in which performed. Nothing in this Agreement shall in any way be construed
to constitute Consultant as an agent, employee or representative of the Company. Without limiting the generality of the foregoing,
Consultant is not authorized to bind the Company to any liability or obligation or to represent that Consultant has any such authority.
Consultant agrees to furnish (or reimburse the Company for) all tools and materials necessary to accomplish this Agreement and
shall incur all expenses associated with performance, except as expressly provided in Exhibit A. Consultant acknowledges
and agrees that Consultant is obligated to report as income all compensation received by Consultant pursuant to this Agreement.
Consultant agrees to and acknowledges the obligation to pay all self-employment and other taxes on such income.

 

    
	 	- 4 -	 

     

    

 

B.    Benefits. The Company
and Consultant agree that Consultant will receive no Company-sponsored benefits from the Company. If Consultant is reclassified
by a state or federal agency or court as Company’s employee, Consultant will become a reclassified employee and will receive
no benefits from the Company, except those mandated by state or federal law, even if by the terms of the Company’s benefit
plans or programs of the Company in effect at the time of such reclassification, Consultant would otherwise be eligible for such
benefits.

 

8.    
Indemnification. Consultant agrees to indemnify and hold harmless the Company and its directors, officers and employees
from and against all taxes, losses, damages, liabilities, costs and expenses, including attorneys’ fees and other legal expenses,
arising directly or indirectly from or in connection with (A) any negligent, reckless or intentionally wrongful act of Consultant
or Consultant’s assistants, employees or agents, (B)  any breach by the Consultant or Consultant’s assistants,
employees or agents of any of the covenants contained in this Agreement, (C) any failure of Consultant to perform the Services
in accordance with all applicable laws, rules and regulations, or (D) any violation or claimed violation of a third party’s
rights resulting in whole or in part from the Company’s use of the work product of Consultant under this Agreement. This
Agreement does not extinguish any other rights that Consultant has as a former employee and officer to benefit from the Company’s
directors and officers liability insurance or the Company’s agreement to indemnify, defend and hold Consultant harmless for
any costs, fees or liability arising out of a claim, demand, suit, action, damages, loss, expense, charge or cause of action filed
against by third parties arising out of Consultant’s former employment at Aptose to the extent such costs, fees or liability
are not covered by any applicable insurance policy held by Aptose, as agreed upon in the Confidential
Separation and Release Agreement.

 

9.     Nonsolicitation.
From the date of this Agreement until 12 months after the termination of this Agreement (the “Restricted Period”),
Consultant will not, without the Company’s prior written consent, directly or indirectly, solicit or encourage any employee
or contractor of the Company or its affiliates to terminate employment with, or cease providing services to, the Company or its
affiliates. During the Restricted Period, Consultant will not, whether for Consultant’s own account or for the account of
any other person, firm, corporation or other business organization, intentionally interfere with any person who is or during the
period of Consultant’s engagement by the Company was a partner, supplier, customer or client of the Company or its affiliates.

 

10.  Arbitration and Equitable Relief.

 

A.    Arbitration. In
consideration of Consultant’s rights under this Agreement, the Company’s promise to arbitrate disputes under this Agreement,
and the receipt of compensation paid to Consultant by the Company, at present and in the future, Consultant HEREBY WAIVES CONSULTANT’S
RIGHT TO A TRIAL BEFORE A JUDGE OR JURY AND agrees that any and all controversies, claims, or disputes with anyone (including the
Company and any employee, officer, director, shareholder or benefit plan of the Company in its capacity as such or otherwise),
whether brought on an individual, group, or class basis, arising out of, relating to, or resulting from Consultant’s performance
of the Services under this Agreement or the termination of this Agreement, including any breach of this Agreement, shall be subject
to binding arbitration under the Arbitration Rules set forth in California Code of Civil Procedure Section 1280 through 1294.2,
including Section 1283.05 (the “Rules”) and pursuant to California law. 

 

    
	 	- 5 -	 

     

    

 

B.    Procedure. Consultant
agrees that any arbitration will be administered by the American Arbitration Association (“AAA”), and that the
neutral arbitrator will be selected in a manner consistent with AAA’s National Rules for the Resolution of Employment Disputes.
Consultant agrees that the arbitrator shall have the power to decide any motions brought by any party to the arbitration, including
motions for summary judgment and/or adjudication, motions to dismiss and demurrers, and motions for class certification, prior
to any arbitration hearing. Consultant also agrees that the arbitrator shall have the power to award any remedies available under
applicable law, and that the arbitrator shall award attorneys’ fees and costs to the prevailing party except as prohibited
by law. Consultant understands that the Company will pay for any administrative or hearing fees charged by the arbitrator or AAA,
except that Consultant shall pay the first $125.00 of any filing fees associated with any arbitration Consultant initiates. Consultant
agrees that the arbitrator shall administer and conduct any arbitration in a manner consistent with the Rules and that to the extent
that the AAA’s National Rules for the Resolution of Employment Disputes conflict with the Rules, the Rules shall take precedence.
Consultant agrees that the decision of the arbitrator shall be in writing.

 

C.    Remedy. Except
as provided by the Rules, LAW, and this Agreement, arbitration shall be the sole, exclusive and final remedy for any dispute between
the Company and Consultant. Accordingly, except as provided for by the Rules, LAW, and this Agreement, neither the Company nor
Consultant will be permitted to pursue court action regarding claims that are subject to arbitration. Notwithstanding, the arbitrator
will not have the authority to disregard or refuse to enforce any lawful Company policy, and the arbitrator shall not order or
require the Company to adopt a policy not otherwise required by law.

 

D.    Availability of Injunctive
Relief. CONSULTANT agreeS that EITHER THE COMPANY or consultant may petition a court
for provisional relief, including injunctive relief, as permitted by the Rules, including, but not limited to, where either THE
COMPANY or consultant alleges or claims a violation of this Agreement between Consultant and the Company or any other agreement
regarding trade secrets, confidential information, nonsolicitation or Labor Code §2870. CONSULTANT understandS that any breach
or threatened breach of such an agreement (INCLUDING THIS AGREEMENT) will cause irreparable injury and that money damages will
not provide an adequate remedy therefor, and both CONSULTANT AND THE COMPANY hereby consent to the issuance of an injunction. 

 

E.    Administrative Relief.
Consultant understands that this Agreement does not prohibit Consultant from pursuing an
administrative claim with a local, state or federal administrative body such as the Department of Fair Employment and Housing,
the Equal Employment Opportunity Commission or the workers’ compensation board. This Agreement does, however, preclude Consultant
from pursuing court action regarding any such claim.

 

    
	 	- 6 -	 

     

    

 

11.  Miscellaneous.

 

A.    Voluntary Nature of
Agreement. Consultant acknowledges and agrees that Consultant is executing this Agreement voluntarily and without any duress
or undue influence by the Company or anyone else. Consultant further acknowledges and agrees that Consultant has carefully read
this Agreement and that Consultant has asked any questions needed for Consultant to understand the terms, consequences and binding
effect of this Agreement and fully understands it, including that Consultant is waiving the right to a jury trial. Finally,
Consultant agrees that Consultant has been provided an opportunity to seek the advice of an attorney of its choice before signing
this Agreement.

 

B.    Governing Law.
This Agreement shall be governed by the laws of California without regard to California’s conflicts of law rules.

 

C.    Assignability.
Except as otherwise provided in this Agreement, Consultant may not sell, assign or delegate any rights or obligations under this
Agreement.

 

D.    Entire Agreement.
This Agreement constitutes the entire agreement between the parties with respect to the subject matter of this Agreement and supersedes
all prior written and oral agreements between the parties regarding the subject matter of this Agreement. For avoidance of doubt,
this Agreement covers all prior consulting services provided by Consultant to the Company.

 

E.    Headings. Headings
are used in this Agreement for reference only and shall not be considered when interpreting this Agreement.

 

F.    Notices. Any notice
or other communication required or permitted by this Agreement to be given to a party shall be in writing and shall be deemed given
or delivered (i) when delivered personally or by commercial messenger or courier service, (ii) three business days after mailing
if mailed by U.S. registered or certified mail (return receipt requested), or (iii) when sent by facsimile or e-mail if sent during
normal business hours and on the next business day if sent after normal business hours, in each case with confirmation of transmission
by the transmitting equipment, to the party at the party’s contact information set forth on the signature page to this Agreement
or at such other address as the party may have previously specified by like notice.

 

G.    Attorneys’ Fees.
In any arbitration or court action at law or equity that is brought by one of the parties to this Agreement to enforce or interpret
the provisions of this Agreement, the prevailing party will be entitled to reasonable attorneys’ fees, in addition to any
other relief to which that party may be entitled.

 

H.   Severability. If any
provision of this Agreement is found to be illegal or unenforceable, then it shall be severed, and the other provisions shall remain
effective and enforceable to the greatest extent permitted by law.

 

I.     Signatures. This
Agreement may be signed in two counterparts, each of which shall be deemed an original, with the same force and effectiveness as
though executed in a single document. Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic
signature complying with the U.S. federal ESIGN Act of 2000, e.g., www.docusign.com) or other transmission method and any counterpart
so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.

 

(signature pages follow)

 

    
	 	- 7 -	 

     

    

 

IN WITNESS WHEREOF, the parties hereto have
executed this Consulting Agreement as of the Effective Date.

 

	CONSULTANT	 	APTOSE BIOSCIENCES INC.	 
	 	 	 	 	 	 
	Sign:	 	 	Sign:	 	 
	 	 	 	 	 	 
	Name:	Gregory K. Chow	 	Name:	 	 
	 	 	 	Title:	 	 
	 	 	 	 	 	 
	Address for Notice:	 	Address for Notice:	 
	 	 	 
		 	12770 High Bluff Drive, San Diego, Suite 120	 
	 	 	California, 92130	 
	 	 	 	 
	E-mail:	greg.chow7@gmail.com	 	E-mail:	 	 

 

 

 

 

     

     

    

 

EXHIBIT A

 

Services and Compensation

 

1.       Contact.
Consultant’s principal Company contact shall be William Rice.

 

2.       Services.
The Services shall include, but shall not be limited to, accounting-related functions and/or those services customarily associated
with an accountant, and/or (1) Accounting Treatment/Technical Advice, (2) Capital Markets Advisory, and (3) Investment
Banking Introductions.

 

3. Performance of Consulting. The Consultant shall consult
with Company on an as-needed basis from time to time, but not to exceed two (2) hours per week. The Services shall be required
at such times and such places that shall not result in unreasonable inconvenience to the Consultant, recognizing that the Consultant
has other commitments that he may have to accord priority over the performance of the Services.

 

4.       Compensation

 

A.   The Company will pay Consultant $250 per hour, except
that Consultant will not be paid for more than two (2) hours per week, unless otherwise agreed to by Consultant and Company.

 

B.   The Company will reimburse Consultant
for all reasonable expenses incurred by Consultant in performing the Services pursuant to this Agreement, if Consultant receives
written consent from an authorized agent of the Company prior to incurring such expenses and submits receipts for such expenses
to the Company in accordance with Company policy.

 

C.   Within 5 business days of the
end of each month, Consultant shall submit to the Company a written invoice for Services and expenses, and such statement shall
be subject to the approval of the contact person listed above or other designated agent of the Company. Payment terms are net 30
days.

 

	CONSULTANT	 	APTOSE BIOSCIENCES INC.	 
	 	 	 	 	 	 
	Sign:	 	 	Sign:	 	 
	 	 	 	 	 	 
	Name:	Gregory K. Chow	 	Name:	 	 
	 	 	 	Title:

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