Document:

Exhibit 10.1

 

FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT

 

THIS FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT
(this “Amendment”), dated as of April 23, 2022 (the “Amendment Effective Date”), is entered
into by and among HUMANIGEN, INC., a Delaware corporation, and each of the Qualified Subsidiaries (hereinafter collectively referred to
as the “Borrower”), the several banks and other financial institutions or entities from time to time parties to this Agreement
(collectively, referred to as the “Lenders”) , and Hercules, in its capacity as administrative agent and collateral
agent for itself and the Lender (in such capacity, together with its successors and assigns in such capacity, “Agent”).

 

The Borrower, the Lenders
and Agent are parties to a Loan and Security Agreement dated as of March 10, 2021 (as amended, restated or modified from time to
time, the “Loan and Security Agreement”). The Borrower has requested that Agent and Lenders agree to certain amendments
to the Loan and Security Agreement. Agent and Lenders have agreed to such request, subject to the terms and conditions hereof.

 

Accordingly, the parties hereto
agree as follows:

 

SECTION 1      Definitions; Interpretation.

 

(a)       Terms
Defined in Loan and Security Agreement. All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise
defined herein shall have the meanings assigned to them in the Loan and Security Agreement.

 

(b)       Interpretation.
The rules of interpretation set forth in Sections 1.3 and 1.4 of the Loan and Security Agreement shall be applicable to this Amendment
and are incorporated herein by this reference.

 

SECTION 2      Amendments to the Loan and Security
Agreement.

 

(a)       The
Loan and Security Agreement shall be amended as follows effective as of the Amendment Effective Date:

 

(i)       Amended
and Restated Definitions.

 

Clause (x) of the
definition of “Permitted Investment” is hereby amended and restated in its entirety as follows:

 

“(i) Investments
in Foreign Subsidiaries (A) constituting Excluded Subsidiaries not to exceed $250,000 in the aggregate for any such Foreign Subsidiary
or $1,000,000 in the aggregate for all such Foreign Subsidiaries and (B) otherwise approved in advance in writing by Agent; and (ii) a
loan to Humanigen Australia Pty Ltd. in an amount not to exceed $500,000;”

 

(b)       References
Within Loan and Security Agreement. Each reference in the Loan and Security Agreement to “this Agreement” and the words
“hereof,” “herein,” “hereunder,” or words of like import, shall mean and be a reference to the Loan
and Security Agreement as amended by this Amendment.

 

SECTION 3      Conditions of
Effectiveness. The effectiveness of Section 2 of this Amendment shall be subject to the satisfaction of each of the following
conditions precedent:

 

(a)       This
Amendment. Agent shall have received this Amendment, executed by Agent, the Lenders and Borrower.

 

(b)       Joinder
Agreement and Relevant Documentation. Agent shall have received:

 

(i)       a
Joinder Agreement executed by Humanigen Australia Pty Ltd. (“Humanigen Australia”) and Agent;

 

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(ii)       a
copy of an extract of a resolution of the board of directors of Humanigen Australia:

 

(1)       approving
the terms of, and the transactions contemplated by, the Loan Documents to which it is expressed to be a party and resolving that it execute
the Loan Documents to which it is expressed to be a party and including a statement of corporate benefit;

 

(2)       authorising
the execution of each Loan Document to which it is expressed to be a party on its behalf;

 

(3)       authorising
a specified person or persons, on its behalf, as authorised signatory to sign and/or dispatch all documents and notices to be signed and/or
despatched by it under or in connection with the Loan Documents to which it is expressed to be a party;

 

(4)       acknowledging
that the directors are acting for a proper purpose and that its entry into the Joinder Agreement (and its accession to the Loan Documents
under it) and each other Loan Document (to which it is a party), and the performance of each Loan Document (to which it is a party) is
in its best interests, and for its commercial benefit and acknowledging that it was solvent at the time of deciding to commit to entering
into each Loan Document (to which it is a party) and will not become insolvent by entering into and performing its obligations under each
Loan Document (to which it is a party);

 

(5)       confirming
that its execution of each Loan Document (to which it is a party) is for a proper purpose reasonably connected with its actual or potential
business, and in accordance with its constitution; and

 

(6)       confirming
that its execution of the Loan Documents (to which it is a party) would not cause it or any other person to contravene Chapter 2E or Part
2J.3 of the Corporations Act 2001 (Cth) (“Australian Corporations Act”); and

 

(iii)       a
certificate of a director of the Humanigen Australia:

 

(1)       attaching:

 

a.       a copy
of the constitutional documents and certificate of registration of Humanigen Australia;

 

b.        a specimen
of the signature of each person authorised by the resolution referred to in paragraph 3(b)(ii) above; and

 

(iv)       confirming
that:

 

a.       borrowing
or guaranteeing or securing, as appropriate, the Term Commitments would not cause any borrowing, guarantee, security or similar limit
binding on it to be exceeded;

 

b.       it is
solvent for the purposes of section 95A of the Australian Corporations Act and there are no grounds for suspecting that it will not continue
to be so after executing and complying with its obligations under the Loan Documents to which it is (or will become) a party;

 

c.       it has
complied with the provisions of Chapter 2E or Part 2J.3 of the Australian Corporations Act in connection with its entry into and performance
of any of its obligations under the Loan Documents to which it is (or will become) a party; and

 

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(c)General Security
Deed.Humanigen Australia shall have granted all asset security to the Agent pursuant to a general security deed in form and substance
satisfactory to Agent.

 

(d)       Representations
and Warranties; No Default. On the Amendment Effective Date, after giving effect to the amendment of the Loan and Security Agreement
contemplated hereby:

 

(i)       The
representations and warranties contained in Section 4 shall be true and correct on and as of the Amendment Effective Date as though
made on and as of such date, except to the extent such representations and warranties expressly relate to an earlier date, after giving
effect in all cases to any standard(s) of materiality contained in the Agreement as to such representations and warranties; and

 

(ii)       There
exist no Events of Default or events that with the passage of time would result in an Event of Default.

 

SECTION 4      Representations
and Warranties. To induce Agent and Lender to enter into this Amendment, Borrower hereby confirms, as of the date hereof, (a) that
the representations and warranties made by it in Section 5 of the Loan and Security Agreement and in the other Loan Documents are true
and correct in all material respects, except to the extent such representations and warranties expressly relate to an earlier date; provided,
however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified
or modified by materiality in the text thereof; (b) that there has not been and there does not exist a Material Adverse Effect; and (c)
that the information included in the Perfection Certificate delivered to Agent on the Closing Date remains true and correct in all material
respects. For the purposes of this Section 4, (i) each reference in Section 5 of the Loan and Security Agreement to “this
Agreement,” and the words “hereof,” “herein,” “hereunder,” or words of like import in such Section,
shall mean and be a reference to the Loan and Security Agreement as amended by this Amendment, and (ii) any representations and warranties
which relate solely to an earlier date shall not be deemed confirmed and restated as of the date hereof (provided that such representations
and warranties shall be true, correct and complete as of such earlier date).

 

SECTION 5      Miscellaneous.

 

(a)       Loan
Documents Otherwise Not Affected; Reaffirmation. Except as expressly amended pursuant hereto or referenced herein, the Loan and Security
Agreement and the other Loan Documents shall remain unchanged and in full force and effect and are hereby ratified and confirmed in all
respects. The Lenders’ and Agent’s execution and delivery of, or acceptance of, this Amendment shall not be deemed to create
a course of dealing or otherwise create any express or implied duty by any of them to provide any other or further amendments, consents
or waivers in the future. Borrower hereby reaffirms the grant of security under Section 3.1 of the Loan and Security Agreement, subject
to the provisions set forth in Section 3.2 of the Loan and Security Agreement, and hereby reaffirms that such grant of security in the
Collateral secures all Secured Obligations under the Loan and Security Agreement and the other Loan Documents.

 

(b)       Conditions.
For purposes of determining compliance with the conditions specified in Section 3, each Lender that has signed this Amendment shall
be deemed to have consented to, approved or accepted or to be satisfied with, each document or other matter required thereunder to be
consented to or approved by or acceptable or satisfactory to a Lender unless Agent shall have received notice from such Lender prior to
the Amendment Effective Date specifying its objection thereto.

 

(c)       Release.
Borrower hereby fully, finally and forever acquits, quitclaims, releases and discharges Agent and Lenders
and their respective officers, directors, employees, agents, successors and assigns of and from any and all obligations, claims, liabilities,
damages, demands, debts, liens, deficiencies or cause or causes of action to, of or for the benefit (whether directly or indirectly) of
Borrower, at law or in equity, known or unknown, contingent or otherwise, whether asserted or unasserted, whether now known or hereafter
discovered, whether statutory, in contract or in tort, as well as any other kind or character of action now held, owned or possessed (whether
directly or indirectly) by Borrower as of the date of this Amendment on account of, arising out of, related to or concerning, whether
directly or indirectly, proximately or remotely (i) the negotiation, review, preparation or documentation of the Loan Documents or any
other documents or agreements executed in connection therewith, (ii) the administration of the Loan Documents, (iii) the enforcement,
protection or preservation of Agent’s and Lenders’ rights under the Loan Documents, or any other documents or agreements executed
in connection therewith, (iv) the negotiation, review, preparation and documentation of this Amendment or any other documents or agreements
executed in connection herewith, and/or (v) any action or inaction by Agent or Lender in connection with any such documents, instruments
and agreements.

 

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Borrower acknowledges having read and understood
and hereby waives the benefits of Section 1542 of the California Civil Code, which provides as follows (and hereby waives the benefits
of any similar law of the state that may be applicable):

 

“A general release does not extend to
claims that the creditor or releasing party does not know or suspect to exist in his or her favor at the time of executing the release
and that, if known by him or her, would have materially affected his or her settlement with the debtor or released party.”

 

Borrower acknowledges that the foregoing provisions
of this Section 5(c) are intended to be a general release with respect to the matters described therein. Borrower does hereby expressly
acknowledge and agree that the waivers and releases contained in this Amendment shall not be construed as an admission of and/or the existence
of any claims of Borrower against Agent or Lender. Borrower does hereby acknowledge and agree that the value to Borrower of this Amendment
and of the covenants and agreements on the part of Lender contained in this Amendment substantially and materially exceeds any and all
value of any kind or nature whatsoever of any claims or liabilities waived or released by Borrower hereunder.

 

(d)       No
Reliance. Each Borrower hereby acknowledges and confirms to Agent and the Lender that such Borrower is executing this Amendment on
the basis of its own investigation and for its own reasons without reliance upon any agreement, representation, understanding or communication
by or on behalf of any other Person.

 

(e)       Costs
and Expenses. Each Borrower agrees to pay to Agent on the Amendment Effective Date the out-of-pocket costs and expenses of Agent and
the Lenders party hereto, and the fees and disbursements of counsel to Agent and the Lenders party hereto (including allocated costs of
internal counsel), in connection with the negotiation, preparation, execution and delivery of this Amendment and any other documents to
be delivered in connection herewith on the Amendment Effective Date or after such date.

 

(f)       Binding
Effect. This Amendment binds and is for the benefit of the successors and permitted assigns of each party.

 

(g)       Governing
Law. This Amendment and the other Loan Documents shall be governed by, and construed and enforced in accordance with, the laws of
the State of California, excluding conflict of laws principles that would cause the application of laws of any other jurisdiction.

 

(h)       Complete
Agreement; Amendments. This Amendment and the Loan Documents represent the entire agreement about this subject matter and supersede
prior negotiations or agreements with respect to such subject matter. All prior agreements, understandings, representations, warranties,
and negotiations between the parties about the subject matter of this Amendment and the Loan Documents merge into this Amendment and the
Loan Documents.

 

(i)       Severability
of Provisions. Each provision of this Amendment is severable from every other provision in determining the enforceability of any provision.

 

(j)       Counterparts.
This Amendment may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed
and delivered, is an original, and all taken together, constitute one Amendment. Delivery of an executed counterpart of a signature page
of this Amendment by facsimile, portable document format (.pdf) or other electronic transmission will be as effective as delivery of a
manually executed counterpart hereof.

 

(k)       Loan
Documents. This Amendment shall constitute a Loan Document.

 

[Balance of Page Intentionally
Left Blank; Signature Pages Follow]

 

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IN WITNESS WHEREOF, the parties
hereto have duly executed this Amendment, as of the date first above written.

 

	 	BORROWER:
	 	 
	 	Humanigen, inc.
	 	 
	 	Signature:	/s/ Cameron Durrant
	 	 	 
	 	Print Name:	Cameron Durrant
	 	 	 
	 	Title:	Chief Executive Officer

 

    	 	 	 

    	 

    
 

	 	AGENT:
	 	 
	 	HERCULES CAPITAL, INC.
	 	 
	 	Signature:	/s/ Zhuo Huang
	 	 	 
	 	Print Name:	Zhuo Huang
	 	 	 
	 	Title:	Associate General Counsel

 

 

 

 

	 	LENDER:
	 	 
	 	HERCULES CAPITAL, INC.
	 	 
	 	Signature:	Zhuo Huang
	 	 	 
	 	Print Name:	Zhuo Huang
	 	 	 
	 	Title:	Associate General CounselEXHIBIT 4.5
​
[***] Certain information in this exhibit has been omitted because it is permitted to be omitted
by applicable regulatory guidance.
​
​
From: [***]
Sent: 07 February 2022 11:48 AM
To: [***]; [***]
Subject: US Bank Trustee Succession
​
		This message was sent from outside Coherus BioSciences. Proceed with caution. 

​
Hi [***]  and [***],
​
As you may have been previously notified, U.S. Bank National Association has repositioned the legal entity used for its U.S.-based Global Corporate Trust business by transferring substantially all of its corporate trust business to its wholly owned subsidiary, U.S. Bank Trust Company, National Association.  
​
Effective January 29, 2022, U.S. Bank Trust Company, National Association (“U.S. Bank Trust Company”) is the successor trustee under the governing agreements for the Engagement(s) listed below.  U.S. Bank Trust Company is a national trust company having a combined capital and surplus of at least $1,000,000,000, and is subject to supervision or examination by federal authority.  U.S. Bank Trust Company will administer the Engagement(s) from the same office locations and using the same systems and employees as did U.S. Bank.   U.S. Bank Trust Company will maintain the transaction accounts at U.S. Bank National Association.
​
Note that the team that provides service to you remains the same. Please do not hesitate to reach out to me if you have any questions. We appreciate our relationship and thank you for your business.
​
You may wish to consult your outside advisors as to whether you have any reporting obligations.  
​
	234957000
	COHERUS BIOSCIENCES, INC. 1.500% CONVERTIBLE SENIOR 
SUBORDINATED NOTES DUE 04/15/2026

​
Best,
[***]
​
[***] 
Vice President, Relationship Manager
p. [***]  | c. [***]  | [***]
U.S. Bank Global Corporate Trust 
1 California Street, Suite 1000, San Francisco, CA  94111| SF-CA-SFCT | www.usbank.com
​
**Please notify me by email if you plan to send a package via overnight delivery to the address noted above.  I am currently working remotely & can be reached on my alternate phone number included above.**
​
​
U.S. BANCORP made the following annotations
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