Document:

Common Stock Purchase Warrant

 Exhibit 4.2 
 COMMON STOCK PURCHASE WARRANT 
 To Purchase 337,319
Shares of Common Stock of 
 CELL THERAPEUTICS, INC. 
  

			
	 Initial Issuance Date: July 28, 2009
	  	Warrant No. WC-10,056

 THIS COMMON STOCK PURCHASE WARRANT (this “Warrant”) certifies that,
for value received, TROUT CAPITAL LLC (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or after January 29, 2010 (the
“Initial Exercise Date”) and on or before the nine (9) month anniversary of the Initial Issuance Date (the “Termination Date”) but not thereafter, to subscribe for and purchase from Cell Therapeutics, Inc., a
Washington corporation (the “Company”), up to 337,319 shares (the “Warrant Shares”) of common stock, no par value per share (the “Common Stock”), of the Company. The purchase price of one share
of Common Stock under this Warrant shall be equal to the Exercise Price (as defined in Section 2(b) of this Warrant). 
 Section 1. Definitions. In addition to the terms defined elsewhere in this Warrant, the following terms have the meanings set forth in this Section 1: 
 “Business Day” means any day except Saturday, Sunday, any day which shall be a federal legal holiday in the
United States or any day on which banking institutions in the State of New York are authorized or required by law or other governmental action to close. 
 “Trading Day” means a day on which the Common Stock is traded on a Trading Market. 
 “Trading Market” means the following markets or exchanges on which the Common Stock is listed or quoted for trading on the date in question: the NYSE Amex, The NASDAQ Capital Market, The
NASDAQ Global Market, The NASDAQ Global Select Market or the New York Stock Exchange. 
 “Underwriter” means the Underwriter named in the Underwriting Agreement. 
 “Underwriting Agreement” means that certain Underwriting Agreement, dated July 22, 2009, between the Company and the Underwriter named therein. 
 “VWAP” means, for any date, the price determined by the first of the following clauses that applies:
(a) if the Common Stock is then listed or quoted on a Trading Market, the daily volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the Trading Market on which the Common Stock is then listed or
quoted for trading as reported by Bloomberg L.P. (based on a Trading Day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time)); (b) if the Common Stock is then listed or quoted on the OTC Bulletin Board and the OTC Bulletin
Board is not a Trading Market, the volume weighted average price of the Common Stock for such date (or the nearest preceding date) on the OTC Bulletin Board; (c) if the Common Stock

  

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is not then quoted for trading on the OTC Bulletin Board and if prices for the Common Stock are then reported in the “Pink Sheets” published by Pink OTC Markets, Inc. (or a similar
organization or agency succeeding to its functions of reporting prices), the most recent bid price per share of the Common Stock so reported; or (d) in all other cases, the fair market value of a share of Common Stock as determined by an
independent appraiser selected in good faith by the Holder and reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company. 
 Section 2. Exercise. 
 (a) Exercise of
Warrant. Exercise of the purchase rights represented by this Warrant may be made, in whole or in part, at any time or times on or after the Initial Exercise Date and on or before the Termination Date by (1) delivery to the Company of a duly
executed facsimile copy of a Notice of Exercise, the form of which is attached to this Warrant (the “Notice of Exercise”), (or such other office or agency of the Company as it may designate by notice in writing to the registered
Holder at the address of the Holder appearing on the books of the Company); provided, however, that within five (5) Trading Days of the date said Notice of Exercise is delivered to the Company, if this Warrant is exercised in
full, the Holder shall have surrendered this Warrant to the Company and (2) the Company shall have received payment of the aggregate Exercise Price (as defined in Section 2(b) of this Warrant) of the Warrant Shares thereby purchased
by wire transfer or cashier’s check drawn on a United States bank. Notwithstanding anything herein to the contrary, the Holder shall not be required to physically surrender this Warrant to the Company until the Holder has purchased all of the
Warrant Shares available hereunder and this Warrant has been exercised in full. Partial exercises of this Warrant resulting in purchases of a portion of the total number of Warrant Shares available hereunder shall have the effect of lowering the
outstanding number of Warrant Shares purchasable hereunder in an amount equal to the applicable number of Warrant Shares purchased. The Holder and the Company shall maintain records showing the number of Warrant Shares purchased and the date of such
purchases. The Company shall deliver any objection to any Notice of Exercise within one (1) Business Day of receipt of such notice. In the event of any dispute or discrepancy, the records of the Company shall be controlling and determinative in
the absence of manifest error. The Holder and any assignee, by acceptance of this Warrant, acknowledge and agree that, by reason of the provisions of this paragraph, following the purchase of a portion of the Warrant Shares hereunder, the
number of Warrant Shares available for purchase hereunder at any given time may be less than the amount stated on the face of this Warrant. 
 (b) Exercise Price. The exercise price per share of the Common Stock underlying this Warrant shall be $1.56, subject to adjustment hereunder (the “Exercise Price”).

 (c) Cashless Exercise. If at the time of exercise of this Warrant there is no effective registration
statement registering (or the prospectus contained therein is not available for) the issuance of the Warrant Shares to the Holder and also at such time of exercise all of the Warrant Shares are not then registered for resale by the Holder into the

  

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market at market prices from time to time on an effective registration statement for use on a continuous basis (or the prospectus contained therein is not available for use), then this Warrant
may also be exercised at such time by means of a “cashless exercise” in which the Holder shall be entitled to receive a certificate for the number of Warrant Shares equal to the quotient obtained by dividing [(A-B) (X)] by (A), where:

  

					
	(A)	  	=	  	the VWAP on the Trading Day immediately preceding the date of such election;
			
	(B)	  	=	  	the Exercise Price of this Warrant, as adjusted; and
			
	(X)	  	=	  	the number of Warrant Shares issuable upon exercise of this Warrant in accordance with the terms of this Warrant by means of a cash exercise rather than a cashless
exercise.
			
	(d)	  		  	[Reserved].
			
	(e)	  		  	Mechanics of Exercise.

 (i) Authorization of Warrant Shares. The Company covenants
that all Warrant Shares which may be issued upon the exercise of the purchase rights represented by this Warrant will, upon exercise of the purchase rights represented by this Warrant and payment of the Exercise Price therefor, be duly authorized,
validly issued, fully paid and nonassessable and free from all taxes, liens and charges in respect of the issue thereof (other than taxes in respect of any transfer occurring contemporaneously with such issue). 
 (ii) Delivery of Certificates Upon Exercise. Certificates representing the Warrant Shares shall be transmitted by the
transfer agent of the Company to the Holder by crediting the account of the Holder’s prime broker with the Depository Trust Company through its Deposit Withdrawal Agent Commission (“DWAC”) system if the Company is a participant
in such system and there is an effective registration statement permitting the issuance of the Warrant Shares to or resale of the Warrant Shares by the Holder, and otherwise by physical delivery to the address specified by the Holder in the Notice
of Exercise within three (3) Business Days from the delivery to the Company of the Notice of Exercise, surrender of this Warrant (if required) and payment of the aggregate Exercise Price as set forth above (including, by cashless exercise, if
permitted) (“Warrant Share Delivery Date”). If all or any portion of a Warrant is exercised at a time when there is an effective registration statement to cover the issuance or resale of the Warrant Shares or if the legend is not
required under applicable securities laws, such Warrant Shares shall be issued free of all legends on or before the Warrant Share Delivery Date. This Warrant shall be deemed to have been exercised on the first date on which the Notice of Exercise
has been delivered to the Company, the Company has received the Exercise Price (or documentation of cashless exercise, if permitted) and all taxes required to be paid by the Holder, if any, pursuant to Section 2(e)(vii) of this Warrant
before the issuance of such

  

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shares have been paid. The Warrant Shares shall be deemed to have been issued, and the Holder or any other person so designated to be named therein shall be deemed to have become a holder of
record of such shares for all purposes, on the first date on which the Notice of Exercise has been delivered to the Company, the Company has received the Exercise Price (or documentation of cashless exercise, if permitted) and all taxes required to
be paid by the Holder, if any, pursuant to Section 2(e)(vii) of this Warrant before the issuance of such shares have been paid. 
 (iii) Delivery of New Warrants Upon Exercise. If this Warrant shall have been exercised in part, the Company shall, at the request of a Holder and upon surrender of this Warrant, at the time of
delivery of the certificate or certificates representing Warrant Shares, deliver to the Holder a new Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant, which new Warrant shall in all
other respects be identical with this Warrant. 
 (iv) Rescission Rights. If the Company fails to cause
its transfer agent to transmit to the Holder a certificate or certificates representing the Warrant Shares pursuant to Section 2 of this Warrant by the Warrant Share Delivery Date, then the Holder will have the right to rescind such
exercise. 
 (v) Compensation for Buy-In on Failure to Timely Deliver Certificates Upon Exercise. In
addition to any other rights available to the Holder, if the Company fails to cause its transfer agent to transmit to the Holder a certificate or certificates representing the Warrant Shares pursuant to an exercise on or before the Warrant Share
Delivery Date pursuant to this Section 2(e), and if after such date the Holder is required by its broker to purchase (in an open market transaction or otherwise) shares of Common Stock to deliver in satisfaction of a sale by the Holder
of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”), then the Company shall (1) pay in cash to the Holder the amount by which (x) the Holder’s total purchase price (including
brokerage commissions, if any) for the shares of Common Stock so purchased exceeds (y) the amount obtained by multiplying (A) the number of Warrant Shares that the Company was required to deliver to the Holder in connection with the
exercise at issue times (B) the price at which the sell order giving rise to such purchase obligation was executed, and (2) at the option of the Holder, either reinstate the portion of this Warrant and equivalent number of Warrant Shares
for which such exercise was not honored or deliver to the Holder the number of shares of Common Stock that would have been issued had the Company timely complied with its exercise and delivery obligations hereunder. For example, if the Holder
purchases Common Stock having a total purchase price of $11,000 to cover a Buy-In with respect to an attempted exercise of shares of Common Stock with an aggregate sale price giving rise to such purchase obligation of $10,000, under clause
(1) of the immediately preceding sentence the Company shall be required to pay the Holder $1,000. The Holder shall provide the Company written notice indicating the amounts payable to the Holder in respect of the Buy-In, together

  

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with applicable confirmations and other evidence reasonably requested by the Company. Nothing herein shall limit a Holder’s right to pursue any other remedies available to it hereunder, at
law or in equity including, without limitation, a decree of specific performance and/or injunctive relief with respect to the Company’s failure to timely deliver certificates representing shares of Common Stock upon exercise of this Warrant as
required pursuant to the terms of this Warrant. 
 (vi) No Fractional Shares or Scrip. No fractional
shares or scrip representing fractional shares shall be issued upon the exercise of this Warrant. As to any fraction of a share which the Holder would otherwise be entitled to purchase upon such exercise, the Company shall pay a cash adjustment in
respect of such final fraction in an amount equal to such fraction multiplied by the Exercise Price. 
 (vii)
Charges, Taxes and Expenses. Issuance of certificates for Warrant Shares shall be made without charge to the Holder for any issue or transfer tax or other incidental expense in respect of the issuance of such certificate, all of which taxes
and expenses shall be paid by the Company, and such certificates shall be issued in the name of the Holder or in such name or names as may be directed by the Holder; provided, however, that in the event certificates for Warrant Shares
are to be issued in a name other than the name of the Holder, this Warrant when surrendered for exercise shall be accompanied by the Assignment Form attached hereto duly executed by the Holder; and the Company may require, as a condition thereto,
the payment of a sum sufficient to reimburse it for any transfer tax incidental thereto. 
 (viii) Closing of
Books. The Company will not close its shareholder books or records in any manner which prevents the timely exercise of this Warrant, pursuant to the terms of this Warrant. 
 Section 3. Certain Adjustments. 
 (a) [Reserved]. 
 (b) [Reserved]. 
 (c) [Reserved]. 
 (d) Fundamental Transaction. If, at any time while this Warrant is outstanding, (i) the Company effects any
merger or consolidation of the Company with or into another person, (ii) the Company effects any sale of all or substantially all of its assets in one transaction or a series of related transactions, (iii) any tender offer or exchange
offer (whether by the Company or another person) is completed pursuant to which holders of Common Stock are permitted to tender or exchange a material portion of the Company’s shares for other securities, cash or property, or (iv) the
Company effects any reclassification of the Common Stock or any compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash or property (in any such case, a “Fundamental
Transaction”), then, the

  

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Company shall make appropriate provision to ensure that the Holder will thereafter receive upon exercise of this Warrant at any time after the consummation of a Fundamental Transaction but before
the Termination Date, in lieu of the Warrant Shares (or other stock, securities, cash, assets or other property whatsoever) issuable upon the exercise of this Warrant before such Fundamental Transaction, such shares of stock, securities, cash,
assets or any other property whatsoever (including warrants or other purchase or subscription rights) which the Holder would have been entitled to receive upon the happening of such Fundamental Transaction had this Warrant been exercised immediately
before such Fundamental Transaction (without regard to any limitations on the exercise of this Warrant). If any holder of Common Stock is given any choice as to the stock, securities, cash, assets or any other property whatsoever (including warrants
or other purchase or subscription rights) to be received in a Fundamental Transaction, then the Holder shall be given the same choice as to what receives it upon any exercise of this Warrant following such Fundamental Transaction. The Company shall
cause any successor entity in a Fundamental Transaction in which the Company is not the survivor to assume in writing all of the obligations of the Company under this Warrant and the Underwriting Agreement (and any other documents or agreements
executed and delivered to the Holders in connection with the transactions contemplated thereunder) in accordance with the provisions of this Section 3(d) pursuant to written agreements in form and substance reasonably satisfactory to the
Holder and approved by the Holder (without unreasonable delay) before such Fundamental Transaction. The provisions of this paragraph shall apply similarly and equally to successive Fundamental Transactions and shall be applied as if this Warrant
(and any such subsequent warrants) were fully exercisable and without regard to any limitations on the exercise of this Warrant (provided that the Holder shall continue to be entitled to the benefit of the Maximum Percentage, applied however with
respect to shares of capital stock registered under the Exchange Act and thereafter receivable upon exercise of this Warrant (or any such other warrant)). 
 (e) Calculations. All calculations under this Section 3 shall be made to the nearest cent or the nearest share, as the case may be. For purposes of this Section 3, the
number of shares of Common Stock deemed to be issued and outstanding as of a given date shall be the sum of the number of shares of Common Stock (excluding treasury shares, if any) issued and outstanding. 
 (f) Notice to Holder. 
 (i) Adjustment to Exercise Price. Whenever the Exercise Price is adjusted pursuant to this Section 3, the Company shall promptly mail to the Holder a notice setting forth the Exercise
Price after such adjustment and setting forth a brief statement of the facts requiring such adjustment. 
 (ii)
Notice to Allow Exercise by Holder. If (A) the Company shall declare a dividend (or any other distribution in whatever form) on the Common Stock; (B) the Company shall declare a special nonrecurring cash dividend on or a redemption
of the Common Stock; (C) the Company shall authorize the granting to all holders of the Common Stock rights or

  

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warrants to subscribe for or purchase any shares of capital stock of any class or of any rights; (D) the approval of any shareholders of the Company shall be required in connection with any
reclassification of the Common Stock, any consolidation or merger to which the Company is a party, any sale or transfer of all or substantially all of the assets of the Company, or any compulsory share exchange whereby the Common Stock is converted
into other securities, cash or property; or (E) the Company shall authorize the voluntary or involuntary dissolution, liquidation or winding up of the affairs of the Company; then, in each case, the Company shall cause to be mailed to the
Holder at its last address as it shall appear upon the Warrant Register of the Company, at least twenty (20) calendar days before the applicable record or effective date hereinafter specified, a notice stating (x) the date on which a
record is to be taken for the purpose of such dividend, distribution, redemption, rights or warrants, or if a record is not to be taken, the date as of which the holders of the Common Stock of record to be entitled to such dividend, distributions,
redemption, rights or warrants are to be determined or (y) the date on which such reclassification, consolidation, merger, sale, transfer or share exchange is expected to become effective or close, and the date as of which it is expected that
holders of the Common Stock of record shall be entitled to exchange their shares of the Common Stock for securities, cash or other property deliverable upon such reclassification, consolidation, merger, sale, transfer or share exchange; provided
that the failure to mail such notice or any defect therein or in the mailing thereof shall not affect the validity of the corporate action required to be specified in such notice. To the extent that any notice provided hereunder constitutes, or
contains, material, non-public information regarding the Company or any of its subsidiaries, the Company shall forthwith file such notice with the Commission pursuant to a Current Report on Form 8-K. The Holder is entitled to exercise this Warrant
during the period commencing on the date of such notice to the effective date of the event triggering such notice. 
 Section 4. Transfer of Warrant. 
 (a) Transferability. This Warrant and all
rights hereunder are transferable, in whole or in part, upon prior written notice to the Company and surrender of this Warrant at the principal office of the Company, together with a written assignment of this Warrant substantially in the form
attached hereto duly executed by the Holder or its agent or attorney and funds sufficient to pay any transfer taxes payable upon the making of such transfer. Upon such surrender and, if required, such payment, the Company shall execute and deliver a
new Warrant or Warrants in the name of the assignee or assignees and in the denomination or denominations specified in such instrument of assignment, and shall issue to the assignor a new Warrant evidencing the portion of this Warrant not so
assigned, and this Warrant shall promptly be cancelled. 
  

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 The Holder agrees by its acceptance of this Warrant that there are
significant restrictions pursuant to Rule 5110 (“Rule 5110”) of the rules and regulations of the Financial Industry Regulation Authority, Inc. against transferring this Warrant and the shares of Common Stock issuable upon exercise
of this Warrant. By its acceptance of this Warrant, the Holder agrees that it will not, sell, transfer, assign, pledge or hypothecate this Warrant, or any potion hereof, or be the subject of any hedging, short sale, derivative, put or call
transaction that would result in the effective economic disposition of this Warrant or the shares of Common Stock issuable upon exercise of this Warrant other than in accordance with Rule 5110. 
 (b) New Warrants. This Warrant may be divided or combined with other Warrants upon prior written notice to the Company
and presentation of this Warrant at the aforesaid office of the Company, together with a written notice specifying the names and denominations in which new Warrants are to be issued, signed by the Holder or its agent or attorney. Subject to
compliance with Section 4(a) of this Warrant, as to any transfer which may be involved in such division or combination, the Company shall execute and deliver a new Warrant or Warrants in exchange for the Warrant or Warrants to be divided
or combined in accordance with such notice. All Warrants issued on transfers or exchanges shall be dated the initial issuance date set forth on the first page of this Warrant and shall be identical with this Warrant except as to the number of
Warrant Shares issuable pursuant thereto. 
 (c) Warrant Register. The Company shall register this
Warrant, upon records to be maintained by the Company for that purpose (the “Warrant Register”), in the name of the record Holder from time to time. The Company may deem and treat the registered Holder of this Warrant as the
absolute owner of this Warrant for the purpose of any exercise of this Warrant or any distribution to the Holder, and for all other purposes, absent actual notice to the contrary. 
 Section 5. Miscellaneous. 
 (a) Title to Warrant. Before the Termination Date and subject to compliance with applicable laws and Section 4 of this Warrant, this Warrant and all rights hereunder are transferable,
in whole or in part, at the office or agency of the Company by the Holder in person or by duly authorized attorney, upon surrender of this Warrant together with the Assignment Form annexed hereto properly endorsed. 
 (b) No Rights as Shareholder Until Exercise. This Warrant does not entitle the Holder to any voting rights or other
rights as a shareholder of the Company before the exercise of this Warrant. 
 (c) Loss, Theft, Destruction or
Mutilation of Warrant. The Company covenants that upon receipt by the Company of evidence reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Warrant, and in case of loss, theft or destruction, of indemnity or
security reasonably satisfactory to it (which shall not include the posting of any bond), and upon surrender and cancellation of such Warrant, if mutilated, the Company will make and deliver a new Warrant of like tenor and dated as of such
cancellation, in lieu of such Warrant. 
  

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 (d) Saturdays, Sundays, Holidays, etc. If the last or appointed day
for the taking of any action or the expiration of any right required or granted herein shall be a Saturday, Sunday or a legal holiday, then such action may be taken or such right may be exercised on the next succeeding day not a Saturday, Sunday or
legal holiday. 
 (e) Authorized Shares. The Company covenants that during the period this Warrant is
outstanding, it will reserve from its authorized and unissued shares of Common Stock a sufficient number of shares to provide for the issuance of the Warrant Shares upon the exercise of any purchase rights under this Warrant. The Company further
covenants that its issuance of this Warrant shall constitute full authority to its officers who are charged with the duty of executing stock certificates to execute and issue the necessary certificates for the Warrant Shares upon the exercise of the
purchase rights under this Warrant. The Company will take all such reasonable action as may be necessary to assure that such Warrant Shares may be issued as provided herein without violation of any applicable law or regulation, or of any
requirements of the Trading Market upon which the Common Stock may be listed. 
 Except and to the extent as
waived or consented to by the Holder, the Company shall not by any action, including, without limitation, amending its Amended and Restated Articles of Incorporation (as amended and restated from time to time) or through any reorganization, transfer
of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will at all times in good faith assist in the
carrying out of all such terms and in the taking of all such actions as may be necessary or appropriate to protect the rights of the Holder as set forth in this Warrant against impairment. Without limiting the generality of the foregoing, the
Company will (i) not increase the par value of any Warrant Shares above the amount payable therefor upon such exercise immediately before such increase in par value, (ii) take all such action as may be necessary or appropriate in order
that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant, and (iii) use commercially reasonable efforts to obtain all such authorizations, exemptions or consents from any
public regulatory body having jurisdiction thereof as may be necessary to enable the Company to perform its obligations under this Warrant. 
 Before taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in the Exercise Price, the Company shall obtain all such
authorizations or exemptions thereof, or consents thereto, as may be necessary from any public regulatory body or bodies having jurisdiction thereof. 
 (f) Jurisdiction. All questions concerning the construction, validity, enforcement and interpretation of this Warrant shall be determined in accordance with the provisions of the Underwriting
Agreement. 
  

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 (g) Restrictions. The Holder acknowledges that Warrant Shares
acquired upon the exercise of this Warrant, if not issued to the Holder pursuant to an effective registration statement, will have restrictions upon resale imposed by state and federal securities laws. 
 (h) Nonwaiver and Expenses. No course of dealing or any delay or failure to exercise any right hereunder on the part
of the Holder shall operate as a waiver of such right or otherwise prejudice the Holder’s rights, powers or remedies. Without limiting any other provision of this Warrant or the Underwriting Agreement, if the Company willfully and knowingly
fails to comply with any provision of this Warrant, which results in any material damages to the Holder, the Company shall pay to the Holder such amounts as shall be sufficient to cover any costs and expenses including, but not limited to,
reasonable attorneys’ fees, including those of appellate proceedings, incurred by the Holder in collecting any amounts due pursuant hereto or in otherwise enforcing any of its rights, powers or remedies hereunder. 
 (i) Notices. Any notice, request or other document required or permitted to be given or delivered to the Holder by the
Company, or vice versa, shall be delivered in accordance with the notice provisions of the Underwriting Agreement. 
 (j) Limitation of Liability. No provision of this Warrant, in the absence of any affirmative action by the Holder to exercise this Warrant or purchase Warrant Shares, and no enumeration herein of the rights or privileges of the
Holder, shall give rise to any liability of the Holder for the purchase price of any Common Stock or as a shareholder of the Company, whether such liability is asserted by the Company or by creditors of the Company. 
 (k) Remedies. The Holder, in addition to being entitled to exercise all rights granted by law, including recovery of
damages, will be entitled to specific performance of its rights under this Warrant. The Company agrees that monetary damages would not be adequate compensation for any loss incurred by reason of a breach by it of the provisions of this Warrant and
hereby agrees to waive the defense in any action for specific performance that a remedy at law would be adequate. 
 (l) Successors and Assigns. Subject to applicable securities laws, this Warrant and the rights and obligations evidenced hereby shall inure to the benefit of and be binding upon the successors of the Company and the successors and
permitted assigns of the Holder. The provisions of this Warrant are intended to be for the benefit of all holders from time to time of this Warrant and shall be enforceable by any such holder or holder of Warrant Shares. 
 (m) Amendment. The Company and the Underwriter may from time to time supplement or amend this Warrant without the
approval of any holder in order to cure any ambiguity, to correct or supplement any provision contained herein that may be defective or inconsistent with any other provisions herein, or to make any other provisions in regard to matters or questions
arising hereunder that the Company and the Underwriter may deem necessary or desirable and that the Company and the Underwriter deem shall not adversely affect the interest of any such holder. All other modifications or amendments shall require the
written consent of, and be signed by, the party against whom enforcement of the modification or amendment is sought. 
  

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 (n) Severability. Wherever possible, each provision of this Warrant
shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Warrant shall be prohibited by or invalid under applicable law, such provision shall be ineffective to the extent of such prohibition
or invalidity, without invalidating the remainder of such provisions or the remaining provisions of this Warrant. 
 (o) Headings. The headings used in this Warrant are for the convenience of reference only and shall not, for any purpose, be deemed a part of this Warrant. 
 [Remainder of this Page Intentionally Left Blank.] 
  

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 IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by its officer
thereunto duly authorized. 
 Dated: July 28, 2009 
  

	
	CELL THERAPEUTICS, INC.
	
	 /s/ Louis A. Bianco

	 Louis A. Bianco
 Executive Vice
President, Finance and Administration

  

 NOTICE OF EXERCISE 
  

	TO:	Cell Therapeutics, Inc. 

 (1)
The undersigned hereby elects to purchase                  Warrant Shares of the Company pursuant to the terms of the attached Warrant (only if exercised in
full), and tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if any. 
 (2)
Payment shall take the form of (check applicable box): 
  ̈ in lawful money of
the United States; or 
  ̈ if so allowed, the cancellation of such number of
Warrant Shares as is necessary, in accordance with the formula set forth in subsection 2(c), to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable pursuant to the cashless exercise procedure set forth in
subsection 2(c). 
 (3) Please issue a certificate or certificates representing said Warrant Shares in the name of the
undersigned or in such other name as is specified below: 
                                        
              
 The Warrant Shares shall be delivered to the following DWAC
Account Number or by physical delivery of a certificate to: 
                                        
              
                                        
              
                                        
              

 ASSIGNMENT FORM 
 (To assign the foregoing warrant, execute 
 this form and
supply required information. 
 Do not use this form to exercise the warrant.) 
 FOR VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to 
  

	
	                                        
                                         
                                         whose
address is

	
	                                        
                                         
                                         
                           .

	
	                                        
                                         
                                         
                           

  

							
	 	 	 	 	 Dated:                     ,
            
	  	 
				
		 	 Holder’s Signature:
	 	  
	  	
				
		 	 Holder’s Address:
	 	  
	  	
				
		 		 	  
	  	
			
	 Signature Guaranteed:
	 	  
	  	

 NOTE: The signature to this Assignment Form must correspond with the name as it appears on the face
of the Warrant, without alteration or enlargement or any change whatsoever, and must be guaranteed by a bank or trust company. Officers of corporations and those acting in a fiduciary or other representative capacity should file proper evidence of
authority to assign the foregoing Warrant.Notice of Removal of Rights Agent and Appointment of Successor Rights Agent

 Exhibit 4.1 
 July 29, 2009 
 Computershare Trust Company, N.A. 
 525 Washington Boulevard 
 Jersey City, NJ 07310

 Attention: Adela Forsyth 
 Mellon
Investor Services LLC 
 Newport Office Center VII 
 480 Washington Boulevard 
 Jersey City, New Jersey 07310 
 Attention: Relationship Manager 
  

	 	Re:	Notice of Removal of Rights Agent and Appointment of Successor Rights Agent and Amendment No. 1 to the Rights Agreement (this “Notice and Amendment”)

 Ladies and Gentlemen: 
 1. Reference is made to the Rights Agreement (the “Rights Agreement”), dated as of August 15, 2000, by and between The Dun & Bradstreet Corporation, formerly known as The New
D&B Corporation (the “Company”) and Computershare Trust Company, N.A., f/k/a EquiServe Trust Company, N.A. (“Computershare”). Capitalized terms used but not defined herein shall have the meaning assigned to them in the Rights
Agreement. 
 2. In accordance with Section 21 of the Rights Agreement, the Company hereby: 
 (a) provides notice to Computershare of Computershare’s removal as Rights Agent under the terms of the Rights Agreement, and
Computershare hereby accepts and agrees to such removal, effective October 5, 2009, and waives any and all time periods, notice and other delivery or similar requirements for its removal as Rights Agent by its countersignature to this Notice
and Amendment in the space provided below; and 
 (b) appoints Mellon Investor Services LLC (“Mellon”) as successor
Rights Agent, to act as agent for the Company in accordance with the terms and conditions of the Rights Agreement, and by its countersignature to this Notice and Amendment in the space provided below, Mellon hereby accepts such appointment,
effective October 5, 2009, and hereby certifies that it complies with the requirements of a successor Rights Agent set forth in Section 21 of the Rights Agreement. 
 3. In accordance with the terms of Section 27 of the Rights Agreement, the Company, by resolution adopted by its Board of Directors,
hereby amends the Rights Agreement as follows, effective October 5, 2009, and Mellon, by its countersignature to this Notice and Amendment in the space provided below, hereby agrees to the following amendments to the Rights Agreement, effective
October 5, 2009: 
 (a) Global Amendments. 
 (i) The Rights Agreement is hereby amended by deleting any and all references to “EquiServe Trust Company, N.A.”
and substituting therefor “Mellon Investor Services LLC”. 
 (ii) The Rights Agreement is hereby
amended by deleting any reference to the “gross negligence, bad faith or willful misconduct” of the Rights Agent and replacing it with a reference to the “gross negligence, bad faith or willful misconduct as determined by a final,
non-appealable judgment of a court of competent jurisdiction” of the Rights Agent. 
 4. Amendment to
Section 1: The definition of “Business Day” is hereby amended by deleting the phrase “in which the principal office of the Rights Agent is located” and inserting the phrase “of New York” in its place.

 5. Amendment to Section 2: Section 2 of the Rights Agreement is hereby
amended by deleting the phrase “and the holders of the Rights (who, in accordance with Section 3 hereof, shall prior to the Distribution Date also be the holders of the Common Stock)” from the first sentence of that Section.

 6. Amendment to Section 3(a). 
 (a) Section 3(a) of the Rights Agreement is hereby amended by inserting the phrase “and provided with all necessary
information” after the phrase “and the Rights Agent will, if requested” in the second sentence of that Section. 
 (b) Section 3(a) of the Rights Agreement is hereby amended by inserting the following sentences as the last sentences of that Section: 
 “The Company shall promptly notify the Rights Agent in writing upon the occurrence of the Distribution Date and, if such notification is
given orally, the Company shall confirm the same in writing on or prior to the next Business Day. Until such notice is received by the Rights Agent, the Rights Agent may presume conclusively for all purposes that the Distribution Date has not
occurred.” 
 7. Amendment to Section 3(b): Section 3(b) of the Rights Agreement is hereby amended by
deleting the phrase “the following legend” and inserting the phrase “a legend in substantially the following form” in its place in the fifth sentence of that Section. 
 8. Amendment to Section 6(a): Section 6(a) of the Rights Agreement is hereby amended by inserting the following sentence as
the last sentence of that Section: 
 “The Rights Agent shall have no duty or obligation under any Section of this Agreement
unless and until it is satisfied that any and all taxes and/or charges required under the terms of the Rights Agreement to be paid have been paid in full.” 
 9. Amendment to Section 6(b): Section 6(b) of the Rights Agreement is hereby amended by deleting the word “reasonably” and the phrase “, at the Company’s
request,” from the phrase “of indemnity or security reasonably satisfactory to them, and, at the Company’s request, reimbursement to the Company and the Rights Agent”. 
 10. Amendment to Section 7(e): Section 7(e) of the Rights Agreement is hereby amended by adding the phrase “or the
Rights Agent” after the phrase “as the Company”. 
 11. Amendment to Section 9(e): Section 9(e)
of the Rights Agreement is hereby amended by inserting the phrase “or the Rights Agent’s” before the phrase “reasonable satisfaction that no such tax is due”. 
 12. Amendment to Section 14(d): Section 14(d) of the Rights Agreement is hereby amended by inserting following sentences as
the last sentences of that Section: 
 “Whenever a payment for fractional Rights or fractional shares is to be made by the
Rights Agent, the Company shall (i) promptly prepare and deliver to the Rights Agent a certificate setting forth in reasonable detail the facts related to such payments and the prices and/or formulas utilized in calculating such payments, and
(ii) provide sufficient monies to the Rights Agent in the form of fully collected funds to make such payments. The Rights Agent shall have no duty with respect to, and shall not be deemed to have knowledge of any payment for, fractional Rights
or fractional shares under any Section of this Agreement relating to the payment of fractional Rights or fractional shares unless and until the Rights Agent shall have received such a certificate and such monies.” 
 13. Amendment to Section 18(a). Section 18(a) of the Rights Agreement is hereby amended by (i) inserting the phrase
“preparation, delivery, amendment,” before the phrase “administration and execution” in the first sentence of that Section; and (ii) deleting the phrase “or expense” and inserting the phrase “damage, judgment,
fine, penalty, claim, demand, settlement, cost or expense (including, without limitation, the reasonable fees and expenses of legal counsel)” and inserting the phrase “, exercise, performance” before the phrase “and
administration of this Rights Agreement” in the second sentence of that Section. 

 14. Amendment to Section 18(b). Section 18(b) of the Rights Agreement is
hereby amended by inserting the following sentences as the last sentences of that Section: 
 “The Company shall give prompt
written notice to the Rights Agent any time the Company elects to defer issuance or is obligated to provide notice or make an announcement to the Rights holders pursuant to the terms of the Rights Agreement. The Rights Agent shall not be deemed to
have knowledge of, and the Rights Agent shall be fully protected and shall incur no liability for failing to take action in connection with, any event for which the Company is required to provide notice unless and until the Rights Agent has received
such written notice. The provisions of this Section 18 and Section 20 below shall survive the termination of this Agreement, the exercise or expiration of the Rights and the resignation, replacement or removal of the Rights Agent.”

 15. Amendment to Section 19(a). Section 19(a) of the Rights Agreement is hereby amended by replacing all
references to “corporation” with “Person” and deleting the phrase “stock transfer or corporate trust powers” and inserting the phrase “shareholder services business” in its place in the first sentence of that
Section. 
 16. Amendment to Section 20. 
 (a) Section 20 of the Rights Agreement is hereby amended by inserting the phrase “expressly” before the phrase
“imposed by this Rights Agreement” in the first sentence of that Section. 
 (b) Section 20 of the
Rights Agreement is hereby amended by inserting the following as a new Section 20(k): 
 “(k) No provision of this
Agreement shall require the Rights Agent to expend or risk its own funds or otherwise incur any financial liability in the performance of any of its duties or in the exercise of its rights hereunder if it believes that repayment of such funds or
adequate indemnification against such risk or liability is not reasonably assured to it.” 
 17. Amendment to
Section 20(a). Section 20(a) of the Rights Agreement is hereby amended by inserting the phrase “advice or” before the phrase “opinion” in both places where such phrase appears. 
 18. Amendment to Section 20(c). Section 20(c) is hereby amended by adding the following sentences as the last sentences of
that Section: 
 “Anything to the contrary notwithstanding, in no event shall the Rights Agent be liable for special,
punitive, indirect, consequential or incidental loss or damage of any kind whatsoever (including but not limited to lost profits), even if the Rights Agent has been advised of the likelihood of such loss or damage. Any liability of the Rights Agent
under this Agreement will be limited to the amount of annual fees paid by the Company to the Rights Agent.” 
 19.
Amendment to Section 21. Section 21 of the Rights Agreement is hereby amended by replacing all references to “corporation” with “Person.” 
 20. Amendment to Section 26. Section 26 of the Rights Agreement is hereby amended by deleting the phrase “EquiServe
Trust Company, N.A. 525 Washington Boulevard Jersey City, NJ 07310 Attn: Craig Broomfield” and replacing it with the following: 
 “Mellon Investor Services LLC 
 Newport Office Center VII 
 480 Washington Boulevard 
 Jersey City, New Jersey 07310 
 Attention: Relationship Manager 

 with a copy to: 
 Mellon Investor Services LLC 
 Newport Office Center VII 
 480 Washington Boulevard 
 Jersey City, New Jersey 07310 
 Attention: General Counsel” 
 21. Amendment to Section 27.
Section 27 of the Rights Agreement is hereby amended by deleting the last sentence of that Section in its entirety and replacing it with the following: 
 “Upon the delivery of a certificate from an appropriate officer of the Company which states that the supplement or amendment is in compliance with the terms of this Section 27, the Rights Agent
shall execute such supplement or amendment; provided, however, that the Rights Agent may, but shall not be obligated to, enter into any supplement or amendment that affects the Rights Agent’s own rights, duties, obligations or immunities under
this Agreement.” 
 22. Amendment to Section 30. Section 30 of the Rights Agreement is hereby amended by
inserting the following sentence as the last sentence of that Section: 
 “The Rights Agent is entitled always to assume the
Company’s Board of Directors acted in good faith and shall be fully protected and incur no liability in reliance thereon.” 
 23. This Notice and Amendment will be deemed to be a contract made under the internal substantive laws of the State of Delaware and for all purposes shall be governed by and construed in accordance with the internal substantive laws of such
State applicable to contracts to be made and performed entirely within such State, except that all provisions regarding the rights, duties and obligations of the Rights Agent will be governed by and construed in accordance with the laws of the State
of New York applicable to contracts made and to be performed entirely within such State. 
 24. The Rights Agreement shall not
otherwise be supplemented or amended by virtue of this Notice and Amendment, but shall remain in full force and effect. 
 25.
This Notice and Amendment may be executed in any number of counterparts and each of such counterparts will for all purposes be deemed to be an original, and all such counterparts will together constitute but one and the same instrument. 

26. The undersigned officer of the Company, being duly authorized on behalf of the Company, hereby certifies in his or her capacity as an
officer on behalf of the Company to Computershare and to Mellon that this Notice and Amendment is in compliance with the terms of Section 27 of the Rights Agreement. 
 [Signature page follows] 

 IN WITNESS WHEREOF, this Notice and Amendment has been duly executed by the Company,
Computershare and Mellon. 
  

					
	THE DUN & BRADSTREET CORPORATION
		
	By:	 	/s/ Jeffrey S. Hurwitz
		 	Name:	 	Jeffrey S. Hurwitz
		 	Title:	 	SVP, General Counsel & Corporate Secretary
	
	COMPUTERSHARE TRUST COMPANY, N.A.
		
	By:	 	/s/ Dennis V. Moccia
		 	Name:	 	Dennis V. Moccia
		 	Title:	 	Manager, Contract Administration
	
	MELLON INVESTOR SERVICES LLC, as Rights Agent
		
	By:	 	/s/ John I. Sivertsen
		 	Name:	 	John I. Sivertsen
		 	Title:	 	Vice President

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