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                                                                   EXHIBIT 10.18

                                    AMENDMENT
                                       TO
                AMENDED AND RESTATED INCENTIVE COMPENSATION PLAN
                           EFFECTIVE NOVEMBER 15, 2000

         The Caremark Rx, Inc. Amended and Restated Incentive Compensation Plan
(the "Plan") is hereby amended as follows:

         1.       Amendment Regarding Transferability of Nonqualified Stock
Options. Section 7.3(b)(2) of the Plan is hereby amended by deleting Section
7.3(b)(2) in its entirety and substituting the following new Section 7.3(b)(2)
therefor:

                  (b) Nonqualified Stock Options. No nonqualified stock option
         granted under the Incentive Compensation Plan may be sold, transferred,
         pledged, assigned or otherwise alienated or hypothecated, other than by
         will or by the laws of descent and distribution. Notwithstanding the
         foregoing, to the extent not prohibited by any statute, rule or
         regulation applicable to the Incentive Compensation Plan, the
         nonqualified stock options, or the registration with the Securities and
         Exchange Commission of the Shares to be issued upon exercise of the
         nonqualified stock options, the Committee may, in its discretion,
         authorize all or a portion of nonqualified stock options granted to a
         Participant to be on terms which permit transfer by such Participant to
         (i) the spouse, children or grandchildren of the Participant
         ("Immediate Family Members"), (ii) a trust or trusts for the exclusive
         benefit of such Immediate Family Members, or (iii) a partnership in
         which such Immediate Family Members are the only partners, provided
         that (A) the Award Agreement pursuant to which such nonqualified stock
         options are granted must be approved by the Committee, and must
         expressly provide for transferability in a manner consistent with this
         Section, and (B) subsequent transfers of transferred nonqualified stock
         options shall be prohibited except those by will or the laws of descent
         and distribution. Following transfer, any such nonqualified stock
         options shall continue to be subject to the same terms and conditions
         as were applicable immediately prior to transfer, provided that for
         purposes of this Incentive Compensation Plan, the term "Participant"
         shall be deemed to refer to the transferee. The events of termination
         of employment shall continue to be applied with respect to the original
         Participant, following which the nonqualified stock options shall be
         exercisable by the transferee only to the extent, and for the periods
         specified in Section 7.4. Notwithstanding the foregoing, should the
         Committee provide that nonqualified stock options granted be
         transferable, the Company by such action incurs no obligation to notify
         or otherwise provide notice to a transferee of early termination of the
         nonqualified stock option. In the event of a transfer, as set forth
         above, the original Participant is and will remain subject to and
         responsible for any applicable withholding taxes upon the exercise of
         such nonqualified stock options.

         2.       Effective Date. The effective date of this Amendment shall be
November 15, 2000.

         3.       Miscellaneous.

                  (a) Capitalized terms not otherwise defined herein shall have
         the meanings given them in the Plan.

                  (b) Except as specifically amended hereby, the Plan shall
         remain in full force and effect.

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         IN WITNESS WHEREOF, the Company has caused this Amendment to the
Caremark Rx, Inc. Amended and Restated Incentive Compensation Plan to be
executed as of the Effective Date.

                                    CAREMARK RX, INC.

                                    -------------------------------------------

                                    Sara J. Finley, Corporate Secretary

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                                                                   EXHIBIT 10.19

                                SECOND AMENDMENT
                                     TO THE
                   CAREMARK RX, INC. 1992 STOCK INCENTIVE PLAN
                        (FORMERLY THE AMENDED & RESTATED
                 MEDPARTNERS, INC. INCENTIVE COMPENSATION PLAN)

         This Second Amendment to the Caremark Rx, Inc. 1992 Stock Incentive
Plan (formerly the Amended & Restated Medpartners, Inc. Incentive Compensation
Plan) (the "Plan") to be effective as of January 12, 2001.

                                   WITNESSETH:

         WHEREAS, Caremark Rx, Inc. (the "Company") currently sponsors and
maintains the Caremark Rx, Inc. 1992 Stock Incentive Plan (formerly the Amended
& Restated Medpartners, Inc. Incentive Compensation Plan) (the "Plan"); and

         WHEREAS, Section 7.9 of the Plan grants the Compensation Committee of
the Board the power at any time to amend the Plan, and the Compensation
Committee now wishes to amend the Plan to modify the vesting provisions for
options granted under the Plan on and after January 12, 2001;

         RESOLVED, the Plan is hereby amended as indicated below:

                                       1.

         Section 5.4 of the Plan is amended effective as of January 12, 2001, to
read as follows:

                  5.4      Vesting of Stock Options.

                  Except as provided by the Committee in the applicable Award
                  Agreement, Stock Options shall vest and become exercisable as
                  follows:

                           (a)      34% of the Stock Options granted shall vest
                  on the Stock Option grant date;

                           (b)      33% of the Stock Options granted shall vest
                  on each of the first anniversary and second anniversary of the
                  Stock Option grant date; provided, however, that for Stock
                  Options granted prior to January 12, 2001, if during the first
                  year after the Stock Option grant date, the stock price of the
                  Common Stock closes at or above $12.00 (or such other price as
                  determined by the Committee and set forth in the applicable
                  Award Agreement) for any twenty (20) out of thirty (30)
                  consecutive trading days, the 33% of the Stock Options due to
                  vest on the first anniversary of the Stock Option

                             Second Amendment to the
                   Caremark Rx, Inc. 1992 Stock Incentive Plan
                                     Page 1

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                  grant date shall vest immediately at the end of such 20th day,
                  and provided, however, that for Stock Options granted prior to
                  January 12, 2001, if during the second year after the Stock
                  Option grant date, the stock price of the Common Stock closes
                  at or above $18.00 (or such other price as determined by the
                  Committee and set forth in the applicable Award Agreement) for
                  any twenty (20) out of thirty (30) consecutive trading days,
                  the 33% of the Stock Options due to vest on the second
                  anniversary of the Stock Option grant date shall vest
                  immediately at the end of such 20th day.

                                       2.

         The name of the Plan is changed effective as of January 12, 2001 from
the Amended & Restated Medpartners, Inc. Incentive Compensation Plan to the
Caremark Rx, Inc. 1992 Stock Incentive Plan. All references in any Company
documents to the Amended & Restated Medpartners, Inc. Incentive Compensation
Plan shall, after January 12, 2001, be a reference to the Caremark Rx, Inc. 1992
Stock Incentive Plan.

                                       3.

         All other provisions of the Plan not inconsistent herewith are hereby
confirmed and ratified.

                       Approved by the Board of Directors
                       by resolutions on January 12, 2001.

                             Second Amendment to the
                   Caremark Rx, Inc. 1992 Stock Incentive Plan
                                     Page 2<PAGE>   1
                                                                   EXHIBIT 10.21

                                    AMENDMENT
                                       TO
          AMENDED AND RESTATED CAREMARK RX, INC. 1993 STOCK OPTION PLAN
                           EFFECTIVE NOVEMBER 15, 2000

         The Amended and Restated Caremark Rx, Inc. 1993 Stock Option Plan (the
"Plan") is hereby amended as follows:

         1.       Amendment Regarding Transferability of Nonqualified Stock
Options. Section 6.1(e)(2) of the Plan is hereby amended by deleting Section
6.1(e)(2) in its entirety and substituting the following new Section 6.1(e)(2)
therefor:

                  (2)      Nonqualified Stock Options. No NQO granted under the
         Plan may be sold, transferred, pledged, assigned, or otherwise
         alienated or hypothecated, other than by will or by the laws of descent
         and distribution. Notwithstanding the foregoing, to the extent not
         prohibited by any statute, rule or regulation applicable to the Plan,
         the Options or the registration with the Securities and Exchange
         Commission of the Common stock to be issued upon exercise of the
         Option, the Committee may, in its discretion, authorize all or a
         portion of NQOs granted to an optionee to be on terms which permit
         transfer by such optionee to (i) the spouse, children or grandchildren
         of the optionee ("Immediate Family Members"), (ii) a trust or trusts
         for the exclusive benefit of such Immediate Family Members, or (iii) a
         partnership in which such Immediate Family Members are the only
         partners, provided that (y) the Option Agreement pursuant to which such
         NQOs are granted must be approved by the Committee, and must expressly
         provide for transferability in a manner consistent with this Section,
         and (z) subsequent transfers of transferred NQOs shall be prohibited
         except those by will or the laws of descent and distribution. Following
         transfer, any such NQOs shall continue to be subject to the same terms
         and conditions as were applicable immediately prior to transfer,
         provided that for purposes of this Plan, the term "optionee" shall be
         deemed to refer to the transferee. The events of termination of
         employment shall continue to be applied with respect to the original
         optionee, following which the NQOs shall be exercised by the transferee
         only to the extent, and for the periods specified in Section 6.1(g).
         Notwithstanding the foregoing, should the Committee provide that NQOs
         granted be transferable, the Company by such action incurs no
         obligation to notify or otherwise provide notice to a transferee of
         early termination of the NQO. In the event of a transfer, as set forth
         above, the original optionee is and will remain subject to an
         responsible for any applicable withholding taxes upon the exercise of
         such NQOs.

         2.       Effective Date. The effective date of this Amendment shall be
November 15, 2000.

         3.       Miscellaneous.

                  (a)      Capitalized terms not otherwise defined herein shall
have the meanings given them in the Plan.

                  (b)      Except as specifically amended hereby, the Plan shall
remain in full force and effect.

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         IN WITNESS WHEREOF, the Company has caused this Amendment to the
Amended and Restated Caremark Rx, Inc. 1993 Stock Option Plan to be executed as
of the Effective Date.

                                     CAREMARK RX, INC.

                                     ------------------------------------------

                                     Sara J. Finley, Corporate Secretary

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