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EXHIBIT 10.29

                EIGHTH AMENDMENT TO AMENDED AND RESTATED BINDING
                                   TERM SHEET

      This EIGHTH AMENDMENT TO AMENDED AND RESTATED BINDING TERM SHEET (this
"AMENDMENT") is made effective as of November 14, 2005 by and between NORTHWEST
BIOTHERAPEUTICS, INC., a Delaware corporation (the "COMPANY"), and TOUCAN
CAPITAL FUND II, L.P., a Delaware limited partnership ("TOUCAN"). RECITALS

      WHEREAS, the Company and Toucan are party to that certain Binding
Convertible Preferred Stock Term Sheet originally dated April 26, 2004 and
amended and restated on October 22, 2004 as further amended on December 27,
2004, January 26, 2005, April 12, 2005, May 13, 2005, June 16, 2005, July 26,
2005 and September 7, 2005 (the "CONVERTIBLE PREFERRED STOCK TERM SHEET").

      WHEREAS, concurrently herewith, the Company and its affiliates, if any,
and Toucan and its designees, are entering into Amendment No. 10 (the "TENTH
AMENDMENT") to that certain Amended and Restated Recapitalization Agreement by
and between the parties thereto; and

      WHEREAS, in connection with the Tenth Amendment, the Company and Toucan
desire to amend the Convertible Preferred Stock Term Sheet as provided herein.

                                    AGREEMENT

      NOW, THEREFORE, for and in consideration of good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
Company and Toucan agree as follows:

      1. The paragraph of the Convertible Preferred Stock Term Sheet entitled
"Warrants:" is hereby amended and restated in its entirety as follows:

      "The Company shall issue $3.95 million in warrant coverage on the first
      $3.95 million Convertible Preferred Stock purchased for cash (the
      "Preferred Stock Warrants"). Preferred Stock Warrants shall not be issued
      upon conversion of notes, exercise of warrants, or other conversion or
      exercise. The number of warrants to be so issued shall be determined on
      the basis of $0.10 per share. If the total of $3.95 million is invested in
      Convertible Preferred Stock, the number of warrants issued shall be
      exercisable for 3.95 million shares of Convertible Preferred Stock. The
      exercise price of such Preferred Stock Warrants shall be $.04 per share
      (subject to adjustment for stock splits, stock dividends and the like).
      The exercise period shall commence upon issuance of the Preferred Stock
      Warrants, and shall continue for a period of seven (7) years after their
      respective issuance dates."

      2. Unless specifically modified or changed by the terms of this Amendment,
all terms and conditions of the Convertible Preferred Stock Term Sheet shall
remain in effect and shall apply fully as described and set forth in the
Convertible Preferred Stock Term Sheet.

      3. This Amendment may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute
one and the same instrument.

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      The Company and Toucan have executed this EIGHTH AMENDMENT TO AMENDED AND
RESTATED BINDING TERM SHEET as of the day and year first written above.

TOUCAN CAPITAL FUND II, L.P.                     NORTHWEST BIOTHERAPEUTICS, INC.

By: /s/ Linda Powers                       By: /s/ Alton L. Boynton
    ----------------                           --------------------

Name:  Linda Powers                               Name:  Alton L. Boynton

Title: Managing Director                          Title:  President

259085 v2/RE

                                        2exv10w1

 

Exhibit 10.1

NORTH POINTE HOLDINGS CORPORATION

EQUITY INCENTIVE PLAN

STOCK OPTION AWARD

Dear :

You have been granted an option (the “Option”) to purchase shares of common stock of North Pointe
Holdings Corporation (the “Company”) under the North Pointe Holdings Corporation Equity Incentive
Plan (the “Plan”) with the following terms and conditions:

	 	 	 
	Grant Date:
	 	 
	 
	 	 
	Type of Option:
	 	 
	 
	 	 
	Number of Option Shares:
	 	 
	 
	 	 
	Exercise Price per Share:
	 	 
	 
	 	 
	Expiration:

	 	Close of business at the Company headquarters on the
tenth (10th) anniversary of the
Grant Date, subject to earlier termination as described
under “Termination of Employment”
	 
	 	 
	Vesting:

	 	Your Option vests in accordance with the following
schedule, provided you are employed by the Company or
an Affiliate on the applicable vesting date:
	 
	 	 
	 
	 	 
	 
	 	 
	 

	 	Your Option will become fully vested if your employment
terminates as a result of death or Disability. For
purposes of this Agreement, “Disability” means your
inability to perform the material duties of your
occupation as a result of a medically-determinable
physical or mental impairment which can be expected to
result in death or which has lasted or can be expected
to last for a period of at least 12 months, as
determined by the Committee. The Committee may require
you to submit such medical evidence or to undergo a
medical examination by a doctor selected by the
Committee as the Committee determines is necessary in
order to make a determination hereunder.

 

 

	 	 	 
	 

	 	Upon any other termination of employment, the unvested
portion of the Option will terminate on the date of
such termination of employment.
	 
	 	 
	Manner of Exercise:

	 	You may exercise this Option only to the extent vested
and only if the Option has not expired or terminated.
To exercise this Option, you must complete the exercise
form provided by the Company and return it to the
address indicated on the form. Your form must specify
how many shares you wish to purchase and will explain
how you must satisfy the exercise price and withholding
taxes due, if any, upon exercise. The form will be
effective when it is received by the Company. If
someone else wants to exercise this Option after your
death, that person must contact the Company and prove
to the Company’s satisfaction that he or she is
entitled to do so. Your ability to exercise the Option
may be restricted by the Company if required by
applicable law.
	 
	 	 
	Termination of Employment:

	 	If your employment terminates, your Option will
terminate on the close of business at the Company
headquarters as follows:
	 
	 	 

	 	•	 	If your employment terminates as a
result of death or Disability (at a time when you could
not have been terminated for Cause), your Option will
terminate on the first (1st) anniversary of
the date of your termination of employment.
	 
	 	•	 	If your employment terminates for any
other reason (other than Cause, as defined below), your
Option will terminate ninety (90) days after the date
of your termination of employment.

	 	 	 
	 
	 	 
	 

	 	However, in no event will this Option be exercisable
after its Expiration Date.
	 
	 	 
	 

	 	Your entire Option (whether vested or nonvested) is
terminated immediately if your employment is terminated
for Cause. In addition, if you have submitted a notice
of exercise that has not yet been processed and you are
terminated for Cause, your notice of exercise will be
rescinded and your exercise price be returned to you.
For this purpose, “Cause” means: (i) if you are subject
to an employment agreement that contains a definition
of “cause”, such definition; (ii) otherwise, any of the
following as determined by the Committee: (A) violation
of the provisions of any employment agreement,
non-competition agreement, confidentiality agreement,
or similar agreement with the

2

 

	 	 	 
	 

	 	Company or an Affiliate,
or the Company’s or Affiliate’s code of conduct, as
then in effect, (B) conduct rising to the level of
gross negligence or willful misconduct in the course of
employment with the Company or an Affiliate, (C)
commission of an act of dishonesty or disloyalty
involving the Company or an Affiliate, (D) violation of
any federal, state or local law in connection with your
employment, or (E) breach of any fiduciary duty to the
Company or an Affiliate.
	 
	 	 
	Transferability:

	 	You may not transfer or assign this Option for any
reason, other than under your will or as required by
intestate laws. Any attempted transfer or assignment
in violation of this provision will be null and void.
During your lifetime, only you (or your guardian or
legal representative if approved by the Company in the
event of your incapacity) are entitled to exercise the
Option.
	 
	 	 
	Restrictions on Resale:

	 	By accepting this Option, you agree not to sell any
Shares acquired under this Option at a time when
applicable laws, Company policies (including, without
limitation, the Company’s Insider Trading Policy) or an
agreement between the Company and its underwriters
prohibit a sale.
	 
	 	 
	Tax Consequences:

	 	If this Option is designated as a nonqualified stock
option, the exercise of this Option will result in
taxable income to you.
	 
	 	 
	 

	 	If this Option is designated as an incentive stock
option, you understand that for the favorable tax
treatment afforded to incentive stock options to apply:
	 
	 	 

	 	•	 	You must hold the shares acquired
upon exercise for a period of one (1) year from the
date of exercise and two (2) years from the Grant Date.
	 
	 	•	 	The Exercise Price Per Share must
equal at least the fair market value of a Share on the
Grant Date. While the Committee has made a good faith
determination of the fair market value of a Share in
this regard, neither the Committee, the Board nor the
Company can guarantee that such determination will be
considered fair market value, nor will you or any other
individual be entitled to any indemnification for any
failure of the Committee to have made such a
determination.
	 
	 	•	 	If Shares with a fair market value
(as determined on the Grant Date) in excess of $100,000
become exercisable (vested) for the first time in any
calendar year (including for this purpose option shares
granted under all other

3

 

	 	 	 	incentive stock options granted
to you by the Company and its Subsidiaries), the number
of Shares with a fair market value in excess of such
$100,000 limit will be considered issued under a
nonqualified stock option.

	 	•	 	You must exercise this Option within
ninety (90) days after termination of employment for
any reason other than Disability or death.
Accordingly, if you exercise this Option more than
ninety (90) days after such termination (if otherwise
permitted by this Option), you will be treated as
exercising a nonqualified stock option. For this
purpose, if you transfer to the employment of an
Affiliate that is not a subsidiary within the meaning
of Code Section 422, you will be treated as terminated
from employment on the date of such transfer, or if you
are employed by a subsidiary, you will be treated as
terminated from employment on the date such entity
ceases to meet the requirements of Code Section 422.
In addition, you will be considered to have terminated
employment for purposes of these rules on the
ninety-first (91st) day of a military leave, sick leave
or other bona fide leave of absence unless your rights
to return to active employment are guaranteed by law or
contract.
	 
	 	•	 	The excess of the Fair Market Value
of the Shares at the time of exercise over the amount
you pay for such Shares may be an item of adjustment
for alternative minimum tax (AMT) purposes on your
personal tax return.

	 	 	 
	Notice of Sale:

	 	If this Option is designated as an incentive stock
option, you must report to the Secretary of the Company
any disposition of the Shares acquired under this
Option that is made within two (2) years from the Grant
Date or within twelve (12) months from the date you
acquired the Shares (the “Notice Period”). In
addition, the Company may, at any time during the
Notice Period, place a legend or legends on any
certificate(s) for the Option Shares requesting the
Company’s transfer agent to notify the Company of any
transfer of the Shares.
	 
	 	 
	Amendment:

	 	This Stock Option Award may be amended only by written
consent of the Company and the Optionee, unless the
amendment is not to the detriment of the Optionee.
	 
	 	 
	Counterparts:

	 	This Stock Option Award may be executed in counterparts.
	 
	 	 
	Governing Law:

	 	The provisions of Section 9(f) of the Plan apply to
this Stock Option Award.

4

 

This Option is granted under and governed by the terms and conditions of the Plan. Additional
provisions regarding your Option and definitions of capitalized terms used and not defined in this
Option can be found in the Plan.

BY SIGNING BELOW AND ACCEPTING THIS STOCK OPTION AWARD, YOU AGREE TO ALL OF THE TERMS AND

CONDITIONS DESCRIBED HEREIN AND IN THE PLAN. YOU ALSO ACKNOWLEDGE RECEIPT OF THE PLAN.

	 	 	 
	 
	 	 
	 
	 	 
	 

	 	 
	Authorized Officer

	 	Optionee

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