Document:

Form of Promissory Note

 Exhibit 4.1 

 

			
	$                	  	October     , 2010

OXYGEN BIOTHERAPEUTICS, INC. 

PROMISSORY NOTE 

FOR VALUE RECEIVED, Oxygen Biotherapeutics, Inc., a Delaware corporation (the “Company”), promises to pay to the order
of                  (the “Holder”), the principal amount of
                 Dollars ($                ), together with interest, if
applicable, and the Final Payment Premium, as set forth below. Terms not defined herein shall have the meaning given them in the Note Purchase Agreement among the Company, the Holder, and certain other purchaser(s) of the Company’s Promissory
Notes dated as of October 31, 2010, as the same may be amended from time to time (the “Purchase Agreement”). Neither the foregoing reference to the Purchase Agreement nor any provisions thereof shall affect or impair the
absolute and unconditional obligation of the Company to pay the principal, interest, if applicable, and the Final Payment Premium, on this Note as provided herein. 

1. Purchase Agreement. This Note (the “Note”) is one of a series of substantially identical (except with respect
to date and principal amount) notes (collectively the “Notes”) purchased under the Purchase Agreement. The Notes are pari passu. All payments on the Notes shall be made pro rata (based upon the amount advanced under each Note). The
Holder is entitled to the benefits and subject to certain obligations under the Purchase Agreement and may enforce the agreements of the Company contained therein and exercise the remedies provided for thereby as provided therein. The benefits and
rights of the Holder are subject to certain conditions and restrictions also set forth in the Purchase Agreement, which conditions and restrictions may be enforced against the Holder. 

2. Interest. Prior to the Maturity Date (as defined below) or the earlier acceleration of this Note, interest shall not accrue on
the outstanding principal balance of this Note. In the event that this Note is not repaid as of the Maturity Date or upon acceleration, interest shall thereafter accrue on the unpaid principal balance and the unpaid Final Payment Premium at a rate
per annum equal to [•%]. Interest, if applicable, shall be computed on the basis of a 360-day year and actual days elapsed. All interest, if applicable, on this Note shall be due and payable as set forth herein. 

3. Final Payment Premium. The Company shall pay the Holder, at such time as provided in Section 4 below, a premium equal to
                 Dollars ($                ) [the Holder’s pro
rata share of $3,000,000] (the “Final Payment Premium”). 
 4. Payment. 

(a) Upon Maturity. Unless sooner repaid, all outstanding principal and the Final Payment Premium shall be due and payable on the
latest to occur of (i) October 31, 2013 or (ii) such later date as the Holders holding at least a majority of the outstanding aggregate principal amount of the Notes shall have consented to in writing (such date, the “Maturity
Date”). 

 (b) Prepayment. (i) Prior to the Maturity Date, the Company shall have the
option, at its sole discretion, to prepay this Note plus the Final Payment Premium, in whole or in part, without penalty or other premium. (ii) Prior to the Maturity Date, in the event of a Subsequent Closing under that certain Securities
Purchase Agreement dated June 8, 2009, by and among the Company and the Investors identified therein, and upon the request of Holders of the Notes representing at least a majority of the aggregate principal amount of all then-outstanding Notes
sold under the Purchase Agreement, the Company shall prepay the Notes (on a pro rata basis based on the amount advanced under each Note) in an aggregate amount equal to the proceeds received by the Company at the Subsequent Closing. 

(c) Upon Default. Upon an Event of Default (as defined below), all outstanding principal, accrued interest, if applicable, and the
Final Payment Premium, shall be payable immediately. 
 (d) Manner of Payment. All payments shall be made in lawful money
of the United States of America at the address for notice to the Holder provided in the Purchase Agreement. Payment shall be credited first to any accrued interest, second to the Final Payment Premium, third to principal, and
fourth to any other amounts owing to the Holder hereunder or under the Note Purchase Agreement. 
 5. Events of
Default. Each of the following events shall constitute an “Event of Default”: (a) the insolvency or bankruptcy of the Company, or any subsidiary of the Company; (b) the commission of any act of bankruptcy by the
Company; (c) a general assignment for the benefit of the Company’s creditors; (d) the filing by or against the Company, or any subsidiary of the Company, of a petition in bankruptcy or any petition for relief under the federal or
state bankruptcy laws or the continuation of such petition without dismissal for a period of ninety (90) days or more; (e) the appointment of, or the Company’s application for the appointment of, a receiver or trustee or similar
person, to take possession of the property or assets of the Company; (f) the Company shall file a certificate of dissolution under applicable state law or shall be liquidated, dissolved or wound-up or shall commence or have commenced against it
any action or proceeding for dissolution, winding-up or liquidation, or shall take any corporate action in furtherance thereof; (g) the Company shall cease or suspend all material conduct of its operations in the ordinary course of business;
(h) the Company’s failure to timely make any payment (whether principal, interest, the Final Payment Premium or otherwise) under this Note within ten (10) days of when due, whether upon demand or otherwise; or (i) a material
breach of any representations, warranties or covenants set forth in the Purchase Agreement, which has not been cured within ten (10) days after receipt of notice from Holder describing such material breach. The Company shall promptly notify the
Holder in writing of any Event of Default. 
 6. Transfer; Successors and Assigns. The terms and conditions of this Note
shall inure to the benefit of and be binding upon the respective successors and assigns of the parties. Notwithstanding the foregoing, the Holder may not assign, pledge, or otherwise transfer this Note without the prior written consent of the
Company, except for transfers to affiliates of the Holder (including but not limited to the Holders’ respective partners, members, stockholders, directors or executive officers) for which an opinion of counsel shall not be required; provided
that such transfer does not violate applicable securities laws. Subject to the preceding sentence, 
  

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this Note may be transferred only upon surrender of the original Note for registration of transfer, duly endorsed, or accompanied by a duly executed written instrument of transfer in form
satisfactory to the Holder. Thereupon, a new note for the same principal amount and interest (and reflecting any accrued interest) will be issued to, and registered in the name of, the transferee. Interest (if applicable), principal and the Final
Payment Premium are payable only to the registered holder of this Note. 
 7. Governing Law. This Note and all acts and
transactions pursuant hereto and the rights and obligations of the parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of North Carolina, without giving effect to principles of conflicts of law
thereof. 
 8. Notices. Any notice required or permitted by this Note shall be in writing and shall be deemed effectively
given: (a) upon personal delivery to the party to be notified; (b) when sent by confirmed facsimile or electronic transmission if sent during normal business hours of the recipient on a business day, or if not, then on the next business
day; or (c) one (1) business day after deposit with a nationally recognized overnight courier, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the Company and the Holder at
the respective address provided in the Purchase Agreement. 
 9. Lost Documents. Upon receipt by the Company of evidence
reasonably satisfactory to it of the loss, theft, destruction or mutilation of this Note or any note exchanged for it, and an indemnity agreement reasonably satisfactory to the Company (in case of loss, theft or destruction) or surrender and
cancellation of such note (in the case of mutilation), the Company, at its own expense, will make and deliver in lieu of such note a new note of like tenor. 

10. Amendments and Waivers. Any term of this Note may be amended or waived only with the written consent of the Company and the
holders of the Notes representing at least a majority of the aggregate principal amount of all then-outstanding Notes sold under the Purchase Agreement. Any amendment or waiver effected in accordance with this Section 10 shall be binding upon
the Company, all holders of Notes, and each transferee of the Notes. Any waiver by the Company or the Holder of a breach of any provision of this Note shall not operate as or be construed to be a waiver of any other breach of such provision or of
any breach of any other provision of this Note. The failure of the Company or the Holder to insist upon strict adherence to any term of this Note on one or more occasions shall not be considered a waiver or deprive that party of the right thereafter
to insist upon strict adherence to that term or any other term of this Note. By acceptance hereof, the Holder acknowledges that, in the event the required consent is obtained, any term of this Note may be amended or waived with or without the
consent of the Holder. 
 11. Waiver. The Company waives presentment and demand for payment, notice of dishonor, protest
and notice of protest, notice of nonpayment and notice of acceleration of intent of acceleration of this Note, and shall pay all costs of collection when incurred, including, without limitation, reasonable attorneys’ fees, costs and other
expenses. The right to plead any and all statutes of limitations as a defense to any demands hereunder is hereby waived to the fullest extent permitted by law, regardless of and without any notice, diligence, act or omission as or with respect to
the collection of any amount called for hereunder. 
  

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 12. Invalidity. If any provision of this Note is invalid, illegal or unenforceable,
the balance of this Note shall remain in effect, and if any provision is inapplicable to any person or circumstance, it shall nevertheless remain applicable to all other persons and circumstances. In such an event, the parties will in good faith
attempt to effect the business agreement represented by such invalidated term to the fullest extent permitted by law. 
 13.
Attorneys’ Fees. In the event of default by the Company (or its assignee) in the payment of principal, interest or the Final Payment Premium due on this Note, the Holder shall be entitled to receive and the Company (or its assignee)
agrees to pay all costs of collection incurred by the Holder, including, without limitation, reasonable attorney’s fees for consultation, suit and/or settlement. 

 

			
	OXYGEN BIOTHERAPEUTICS, INC.
		
	By:	 	              

	Name:	 	Chris J. Stern
	Title:	 	Chief Executive Officer
		
	By:	 	              

	Name:	 	Michael B. Jebsen
	Title:	 	Chief Financial Officer

  

 4Note Purchase Agreement

 Exhibit 10.1 

OXYGEN BIOTHERAPEUTICS, INC. 

NOTE PURCHASE AGREEMENT 

This NOTE PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of October 12, 2010 by and among Oxygen
Biotherapeutics, Inc., a Delaware corporation (the “Company”), and the purchasers listed on Exhibit A (individually, a “Purchaser” and collectively the “Purchasers”). 

WHEREAS, the Company desires to enter into this Agreement with the Purchasers to issue and sell Five Million Dollars ($5,000,000) of
promissory notes on or before December 31, 2010 in substantially the form attached hereto as Exhibit B (individually, a “Note,” and collectively, the “Notes”); and 

WHEREAS, the Purchasers desire to enter into this Agreement to acquire the Notes on the terms and conditions set forth herein.

 NOW, THEREFORE, in consideration of the mutual promises, representations, warranties, covenants and conditions set forth in
this Agreement, the parties to this Agreement mutually agree as follows: 
 1. AUTHORIZATION AND SALE. 

1.1 Authorization. The Company has authorized the issuance and sale to the Purchasers of the Notes. 

1.2 Sale. Subject to the terms and conditions hereof, each of the Purchasers, severally and not jointly, agrees to purchase from
the Company, and the Company agrees to sell and issue to each of the Purchasers, one or more Notes in an aggregate principal amount not to exceed the amount set forth opposite such Purchaser’s name on Exhibit A. The Company’s
agreement with each of the Purchasers is a separate agreement, and the sale of the Notes to each of the Purchasers is a separate sale. 

1.3 Use of Proceeds. The Company will use the proceeds from the issuance and sale of the Notes for ongoing working capital and
general corporate purposes, including to pay certain fees and expenses related to the issuance of the Notes. 
 1.4 Pari
Passu. The Notes are pari passu. All payments on the Notes shall be made pro rata (based upon the amount advanced). If any Purchaser receives a payment in violation of this provision, such Purchaser will hold such payment in trust for the other
Purchasers and will remit the amount received in violation of this provision to the other Purchasers entitled to same. 

 2. CLOSINGS; DELIVERY; DEFINITIONS. 

2.1 Closings. The purchase and sale of the Notes (the “Closing” and the date upon which such Closing occurs, the
“Closing Date”) shall occur as set forth below. At its option the Company may elect to issue and sell Notes to different Purchasers, up to an aggregate amount not to exceed the Maximum Offering Amount, at separate closings
hereunder, each of which shall be referred to as a “Closing” and the date upon which any such Closing occurs, a “Closing Date”. The Company and the Purchasers agree that the Notes to be issued in each Closing shall
be sold pursuant to and subject to the provisions of this Agreement, modified solely to reflect the date of such Closing and principal amount of such Note. 

2.2 Delivery. At each Closing, subject to the terms and conditions hereof, the Company shall deliver to each Purchaser the Notes
to be purchased by such Purchaser at such Closing, dated the date of the Closing, against payment of the purchase price therefore payable as of the date of such Closing by check or wire transfer. 

2.3 Definitions. Capitalized terms used and not otherwise defined in this Agreement shall have the meanings ascribed to them
below: 
 (a) “Action” shall mean any action, suit, inquiry, notice of violation, proceeding (including any
partial proceeding such as a deposition) or investigation pending or threatened in writing against or affecting the Company or any of its properties before or by any court, arbitrator, governmental or administrative agency, regulatory authority
(federal, state, county, local or foreign), stock market, stock exchange or trading facility. 
 (b)
“Affiliate” shall mean any direct or indirect general or limited partner or member, and a person that directly or indirectly, through one or more intermediaries, controls, is controlled by, or is under common control with, a
Purchaser. 
 (c) “Commission” shall mean the Securities and Exchange Commission. 

(d) “Disclosure Materials” shall mean the SEC Disclosure Documents and the Company’s Schedules to this Agreement,
collectively. 
 (e) “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended. 

(f) “Lien” shall mean any lien, charge, encumbrance, security interest, right of first refusal, preemptive right or
other restrictions of any kind. 
 (g) “Person” means an individual, partnership, corporation, limited
liability company, association, joint stock corporation, trust, joint venture, unincorporated organization or federal, state or local governmental entity or any department, agency or political subdivision thereof. 

(h) “Securities Act” shall mean the Securities Act of 1933, as amended. 

 

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 (i) “Short Sales” shall include, without limitation, all “short
sales” as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and indirect stock pledges, forward sale contracts, options, puts, calls, swaps and similar arrangements (including on a total return
basis), and sales and other transactions through non-US broker dealers or foreign regulated brokers. 
 3. REPRESENTATIONS AND WARRANTIES OF
THE COMPANY. Subject to the exceptions and qualifications set forth on the Schedule of Exceptions attached hereto and incorporated by reference herein, the Company hereby represents and warrants to each Purchaser as follows: 

3.1 Organization and Good Standing; Power and Authority; Qualifications. The Company (i) is a corporation duly organized,
validly existing and in good standing under the laws of Delaware and (ii) has all requisite corporate power and authority to own, lease and operate its properties and to carry on its business as presently conducted and as proposed to be
conducted. The Company has all requisite legal and corporate power to execute and deliver this Agreement and the Notes (collectively, the “Agreements”), to issue and sell the Notes, and to carry out and perform its other obligations
under the terms of the Agreements. The Company is qualified to transact business as a foreign corporation in, and is in good standing under the laws of, all of the jurisdictions wherein the character of the property owned or leased or the nature of
the activities conducted by it makes such qualification necessary, except jurisdictions in which the failure to be so qualified would not have a material adverse effect on the condition (financial or otherwise), results of operations, business or
assets of the Company (a “Material Adverse Effect”). 
 3.2 Authorization. All corporate action on the
part of the Company necessary for the authorization, execution and delivery of the Agreements, the performance of all obligations of the Company hereunder and thereunder and the authorization, issuance and delivery of the Notes sold hereunder has
been taken or will be taken prior to the Closing, and the Agreements, when executed and delivered by the Company, shall constitute valid and legally binding obligations of the Company, enforceable against the Company in accordance with their
respective terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, and other laws of general application affecting enforcement of creditors’ rights generally, and (ii) as
limited by laws relating to the availability of specific performance, injunctive relief, or other equitable remedies. 
 3.3
Valid Issuance of the Notes. The Notes that are being issued to the Purchasers hereunder, when issued, sold and delivered in accordance with the terms hereof for the consideration expressed herein, will be duly and validly issued and free of
any Liens, other than Liens, if any, arising as a result of actions taken by the Purchasers, and restrictions on transfer other than restrictions on transfer under this Agreement and applicable state and federal securities laws. 

3.4 No Conflicts. The execution, delivery and performance of the Agreements by the Company and the consummation by the Company of
the transactions contemplated thereby do 
  

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not and will not (i) conflict with or violate any provision of the Company’s certificate of incorporation, bylaws or other organizational or charter documents, or (ii) conflict
with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, result in the creation of any Lien upon any of the properties or assets of the Company, or give to others any rights of termination,
amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing a Company debt or otherwise) or other understanding to which the Company is a party or
by which any property or asset of the Company is bound or affected, or (iii) result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to which the
Company is subject (including federal and state securities laws and regulations), or by which any property or asset of the Company is bound or affected; except in the case of each of clauses (ii) and (iii), such as could not, individually or in
the aggregate, have or reasonably be expected to result in a Material Adverse Effect. 
 3.5 Filings, Consents and
Approvals. The Company is not required to obtain any consent, waiver, authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other governmental authority or other
Person in connection with the execution, delivery and performance by the Company of the Agreements, other than the filing with the Commission of a Notice of Sale of Securities on Form D under Regulation D of the Securities Act and under applicable
state securities statutes pertaining to the purchase and sale contemplated by this Agreement. 
 3.6 Litigation. There is
no Action that (i) adversely affects or challenges the legality, validity or enforceability of any of the Agreements or (ii) that could, if there were an unfavorable decision, individually or in the aggregate, have or reasonably be
expected to result in a Material Adverse Effect. Neither the Company nor any director or officer thereof (in his or her capacity thereof) is or has been during the ten (10)-year period prior to the date hereof the subject of any Action involving a
claim of violation of or liability under federal or state securities laws or a claim of breach of fiduciary duty. There has not been, and to the knowledge of the Company there is not pending or contemplated, any investigation by the Commission
involving the Company or any current or former director or officer of the Company (in his or her capacity as such). 
 3.7
SEC Disclosure Documents; Financial Statements. The Company has filed all reports required to be filed by the Company under the Securities Act and the Exchange Act for the twenty-four (24) months preceding the date of this Agreement and
will file all reports required to be filed by the Company under the Securities Act and the Exchange Act through the last subsequent Closing Date (such reports, as amended, collectively, the “SEC Disclosure Documents”). As of their
respective dates, the SEC Disclosure Documents have complied or will comply in all material respects with the requirements of the Securities Act and the Exchange Act and the rules and regulations of the Commission promulgated thereunder, and none of
the SEC Disclosure Documents, when filed, contained or will contain any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the
circumstances under which they were made, not misleading. The financial statements of the Company included in the SEC Disclosure Documents comply in all material respects with applicable accounting requirements and the rules

  

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and regulations of the Commission with respect thereto as in effect at the time of filing and were (and will be) prepared in accordance with GAAP applied on a consistent basis during the periods
involved, except as may be otherwise specified in such financial statements or the notes thereto, and fairly present in all material respects the financial position of the Company as of and for the dates thereof and the results of operations and
cash flows for the periods then ended, subject, in the case of unaudited statements, to normal year-end audit adjustments. The Company maintains and will continue to maintain a standard system of accounting established and administered in accordance
with GAAP and the applicable requirements of the Exchange Act. 
 3.8 Acknowledgment Regarding Purchasers’ Purchase of
Notes. The Company acknowledges and agrees that each of the Purchasers is acting solely in the capacity of an arm’s length purchaser with respect to the Agreements and the transactions contemplated thereby. The Company further acknowledges
that no Purchaser is acting as financial advisor or fiduciary of the Company (or in any similar capacity) with respect to this Agreement, and the transactions contemplated hereby and any advice given by any Purchaser or any of their respective
representatives or agents in connection with this Agreement and the transactions contemplated hereby is merely incidental to the Purchasers’ purchase of the Notes. The Company further represents to each Purchaser that the Company’s
decision to enter into this Agreement has been based solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives. 

4. REPRESENTATIONS AND WARRANTIES OF PURCHASERS. Each of the Purchasers severally, and not jointly, represents and warrants to the Company as of
the date hereof as follows: 
 4.1 Organization; Authority. Such Purchaser is an entity duly organized, validly existing
and in good standing under the laws of the jurisdiction of its organization with the requisite corporate or partnership power and authority to enter into and to consummate the transactions contemplated by the applicable Agreements and otherwise to
carry out its obligations thereunder. The execution, delivery and performance by such Purchaser of the transactions contemplated by this Agreement has been duly authorized by all necessary corporate or, if such Purchaser is not a corporation, such
partnership, limited liability company or other applicable like action, on the part of such Purchaser. This Agreement has been duly executed by such Investor and, when delivered by such Purchaser in accordance with terms hereof, will constitute the
valid and legally binding obligation of such Purchaser, enforceable against it in accordance with its terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium, liquidation or similar laws
relating to, or affecting generally the enforcement of, creditors’ rights and remedies or by other equitable principles of general application. 

4.2 Purchase Entirely for Own Account. This Agreement is made with the Purchaser in reliance upon the Purchaser’s
representation to the Company, which, by the Purchaser’s execution of this Agreement, the Purchaser hereby confirms, that the Notes to be acquired by the Purchaser will be acquired for investment for the Purchaser’s own account, not as a
nominee or agent, and not with a view to the resale or distribution of any part thereof, and that the Purchaser has no present intention of selling, granting any participation in, or otherwise distributing the

  

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same, subject to the ability of such of the Purchasers as may be partnerships or limited liability companies to transfer shares to its partners or members and any of the Purchasers to transfer
shares to any Affiliate of such Purchaser in compliance with applicable securities laws. The Purchaser has not been formed for the specific purpose of acquiring the Notes. 

4.3 Purchaser Status. Such Purchaser is an “accredited investor” as defined in Rule 501(a) under the Securities Act.
Such Purchaser is not a registered broker-dealer under Section 15 of the Exchange Act. 
 4.4 General Solicitation.
Such Purchaser is not purchasing the Notes as a result of any advertisement, article, notice or other communication regarding the offered Notes published in any newspaper, magazine or similar media or broadcast over television or radio or presented
at any seminar or any other general solicitation or general advertisement. 
 4.5 Access to Information. Such Purchaser
acknowledges that it has reviewed the Disclosure Materials and has been afforded (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, representatives of the Company concerning the terms and
conditions of the offering of the Notes and the merits and risks of investing in the Company; (ii) access to information about the Company and its financial condition, results of operations, business, properties, management and prospects
sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed
investment decision with respect to the investment. 
 4.6 Independent Investment Decision. Such Purchaser has
independently evaluated the merits of its decision to purchase Notes pursuant to the Agreements, and such Purchaser confirms that it has not relied on the advice of any other Purchaser’s business and/or legal counsel in making such decision.

 4.7 Certain Trading Activities. Such Purchaser has not directly or indirectly, nor has any Person acting on behalf of
or pursuant to any understanding with such Purchaser, engaged in any transactions in the securities of the Company (including, without imitation, any Short Sales involving the Company’s securities) since the time that such Purchaser was first
contacted by the Company regarding an investment in the Company. Such Purchaser covenants that neither it nor any Person acting on its behalf or pursuant to any understanding with it will engage in any transactions in the securities of the Company
(including Short Sales) prior to the time that the transactions contemplated by this Agreement are publicly disclosed. 
 4.8
No Public Market. The Purchaser understands that no public market now exists for any of the Notes issued by the Company and that the Company has made no assurances that a public market will ever exist for its Notes. 

5. CONDITIONS TO CLOSING. 

5.1 Representations and Warranties. The representations and warranties of the Company contained in Section 3 shall be true
and correct in all material respects on and as of 
  

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such Closing with the same force and effect as if they had been made at such Closing, except for items stated as of a particular date, which shall remain true and correct in all material respects
as of such date. 
 5.2 Performance. The Company shall have performed and complied with all agreements and conditions
contained in this Agreement required to be performed or complied with by it on or before such Closing. 
 5.3 No Material
Adverse Effect. From and after the date hereof, no Material Adverse Effect shall have occurred on or before such Closing, and there shall exist no condition, event or occurrence that, individually or in the aggregate, would reasonably be
expected to result in a Material Adverse Effect. 
 5.4 Delivery of Documents. The Company shall have validly executed
and delivered to each Purchaser (i) this Agreement, and (ii) a Note or Notes in the amount purchased by such Purchaser hereunder. 

5.5 Legal Investment. At the time of such Closing, the purchase of the Notes by the Purchasers hereunder shall be legally
permitted by all laws and regulations to which they or the Company are subject. 
 6. MISCELLANEOUS. 

6.1 Successors and Assigns. The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the
respective successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations or
liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. Notwithstanding anything contained herein to the contrary, the Company agrees that the Purchasers may transfer, without an opinion of counsel, the
Notes to their affiliates, including but not limited to their stockholders, directors or executive officers, or partners or members, or other entities controlled by such partners or members; provided that such transfer is not in violation of federal
and state securities laws. 
 6.2 Entire Agreement. This Agreement and the documents referred to herein constitute the
entire agreement among the parties, and no party shall be liable or bound to any other party in any manner by any warranties, representations or covenants except as specifically set forth herein or therein. 

6.3 Governing Law. This Agreement shall be governed, construed and interpreted under the laws of the State of North Carolina,
without regard to the conflicts of laws provisions of the State of North Carolina or any other state. 
 6.4
Counterparts. This Agreement may be executed in two (2) or more counterparts and by facsimile, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

 

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 6.5 Headings. The headings used in this Agreement are used for convenience only and
are not to be considered in construing or interpreting this Agreement. 
 6.6 Notices. All notices required or permitted
hereunder shall be in writing and shall be deemed effectively given: (i) upon personal delivery to the party to be notified; (ii) when sent by confirmed facsimile or electronic transmission if sent during normal business hours of the
recipient on a business day, or, if not, then on the next business day; or (iii) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt (or, in the case
of non-U.S. residents, two (2) business days after deposit with an internationally recognized overnight courier, specifying international priority delivery, with written verification of receipt). All communications shall be sent to the Company
at Oxygen Biotherapeutics, Inc., 2530 Meridian Parkway, Suite 3005, Durham, NC 27713, Attn: Chief Executive Officer, or to a Purchaser at the address set forth for such Purchaser on Exhibit A attached hereto or at such other address as the
Company or the Purchaser may designate by ten (10) days’ advance written notice to the other parties hereto. 
 6.7
Finder’s Fees. Each party represents that it neither is nor will be obligated for any finder’s fee or commission in connection with this transaction. Each Purchaser, severally and not jointly, agrees to indemnify and to hold
harmless the Company from any liability for any commission or compensation in the nature of a finder’s fee (and the costs and expenses of defending against such liability or asserted liability) for which the Purchaser or any of its officers,
employees or representatives is responsible. The Company agrees to indemnify and hold harmless each Purchaser from any liability for any commission or compensation in the nature of a finder’s fee (and the costs and expenses of defending against
such liability or asserted liability) for which the Company or any of its officers, employees or representatives is responsible. 

6.8 Severability. If one or more provisions of this Agreement are held to be unenforceable under applicable law, the parties agree
to renegotiate such provision(s) in good faith, in order to maintain or achieve the economic position enjoyed by each party as close as possible to that under the provision(s) rendered unenforceable. In the event that the parties cannot reach a
mutually agreeable and enforceable replacement for such provision(s), then (i) such provision(s) shall be excluded from this Agreement; (ii) the balance of the Agreement shall be interpreted as if such provision(s) were so excluded; and
(iii) the balance of the Agreement shall be enforceable in accordance with its terms. 
 6.9 Delays or Omissions. No
delay or omission to exercise any right, power or remedy accruing to the Company or the Purchasers upon any breach, default or noncompliance of any Purchaser or the Company under this Agreement shall impair any such right, power or remedy, nor shall
it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent or approval of
any kind or character on the part of the Company or any Purchaser of any breach, default or noncompliance under this Agreement or any waiver on the Company’s or any Purchaser’s part of any provisions or conditions of this Agreement must be
in writing and shall be effective only to the extent 
  

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specifically set forth in such writing and that all remedies, either under this Agreement, by law, or otherwise afforded to the Company and the Purchasers, shall be cumulative and not
alternative. 
 6.10 Amendments and Waivers. Except as otherwise expressly provided herein, any term of this Agreement
may be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance, either retroactively or prospectively and either for a specified period of time or indefinitely) with the written consent of
the Company and the holders of notes representing at least a majority of the aggregate outstanding principal amount of the Notes sold under this Agreement. Any amendment or waiver effected in accordance with this Section shall be binding upon all
parties, and the Company shall promptly give notice to the Purchasers of any amendment effected in accordance with this Section 6.10. 

6.11 Survival of Warranties and Covenants. Except as otherwise expressly set forth herein, the warranties, representations and
covenants of the Company and the Purchasers contained in or made pursuant to this Agreement shall survive the last to occur of the execution and delivery of this Agreement, the Closing and the repayment of the Notes in full as provided for therein,
and for a period of two (2) years thereafter, and shall in no way be affected by any investigation of the subject matter thereof made by or on behalf of the Purchasers or the Company. 

6.12 Further Assurances. Prior to and after the Closing, at the request of the Purchasers, the Company will take, or cause to be
taken, all actions and to do, or cause to be done, and to assist and cooperate in doing, as the Purchasers may reasonably deem necessary or desirable, all things necessary to consummate and make effective in a practicable manner, the Closing, and
the other transactions contemplated by this Agreement and the Notes, including, without limitation, (i) the execution and delivery of any additional waivers, consents, confirmation, agreements, instruments or documents, or the taking of all
actions, whether prior to or after the Closing, necessary to issue and sell the Notes to the Purchasers and (ii) to otherwise carry out the purpose and intent of this Agreement and the Notes. 

6.13 Expenses. Each party hereto shall bear the costs and expenses incurred by it, including attorneys’ and accountants’
fees, in connection with the negotiation and preparation of the Agreements and the consummation of the transactions contemplated thereby. 
  

 9 

 [Signature Page to Note Purchase Agreement] 

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above written. 

 

			
	OXYGEN BIOTHERAPEUTICS, INC.
		
	By:	 	 /s/ Chris J. Stern

	Name:	 	Chris J. Stern
	Title:	 	Chief Executive Officer
		
	By:	 	 /s/ Michael B. Jebsen

	Name:	 	Michael B. Jebsen
	Title:	 	Chief Financial Officer

 [Signature Page to Note Purchase Agreement] 

 

			
	 PURCHASER:

	
	JP SPC 1 Vatea, Segregated Portfolio
		
	By:	 	 /s/ Gregory Pepin

	Name:	 	Gregory Pepin
	Title:	 	Investment Manager

 Exhibit A 

Purchaser 
  

				
	 Name and Address
	  	Amount of Note
		
	 JP SPC 1 Vatea, Segregated Portfolio
	  		
		
	 Rue du Borgeaud, 10b
	  	$	5,000,000
		
	 Gland, Switzerland 1196
	  		
		  	 	 
		
	 TOTAL
	  	$	5,000,000

 Exhibit B 

Form of Senior Unsecured Promissory Note 

See attached. 

 SCHEDULE OF EXCEPTIONS 

OF OXYGEN BIOTHERAPEUTICS, INC. 

(THE “COMPANY”) 

Pursuant to Note Purchase Agreement dated October 31, 2010 (the “Agreement”) by and 

among the Company and the Purchasers party thereto 

This Schedule of Exceptions is qualified in its entirety by reference to the provisions of the Agreement and does not constitute a
representation or warranty of the Company except as expressly provided in the Agreement. 
 Any headings have been inserted in
this Schedule of Exceptions for reference only and do not amend the descriptions of the disclosed items set forth in the Agreement. 

Capitalized terms not otherwise defined herein have the meanings assigned to such terms in the Agreement.

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