Document:

EX-10.10

 Exhibit 10.10 
  

 
 Master Services Agreement 

This Master Services Agreement (this “Agreement”) dated December 24, 2013 (the “Effective
Date”), between Aeglea Development Company, Inc., having a place of business at 815-A Brazos St. #101, Austin, TX 78701 (“Client”) and KBI Biopharma, Inc., having a place of business at 1101 Hamlin Road,
Durham, North Carolina 27704 (“KBI Biopharma”) (Client and KBI Biopharma, each a “Party”, and collectively, the “Parties”). 

Whereas, Client is engaged in the discovery and development of new biological therapeutics; 

Whereas, KBI Biopharma is in the business of providing biological development and clinical manufacturing services; and 

Whereas, Client desires KBI Biopharma to perform certain services in accordance with the terms of this Agreement and KBI Biopharma desires to perform such
services. 
 Now, therefore, in consideration of the above statements, which form part of this Agreement, and other good and valuable consideration, the
sufficiency and receipt of which are hereby acknowledged, the Parties hereto agree as follows: 
  

	1.	Services to be Performed 

  

	1.1	Scope. KBI Biopharma shall use reasonable commercial efforts to perform the services (the “Services”) detailed in the proposals, which have been executed by the Parties, listed on
Attachment One, and incorporated herein by reference (proposals listed on Attachment One and subsequent proposals agreed to by the Parties are each hereinafter referred to as a “Propose”). Any deliverables to be
provided to Client as a result of the performance by KBI Biopharma of the Services shall be set forth in the Proposal (the “Deliverables”). In the event that Client requests KBI Biopharma to perform services beyond the scope
of services specifically stated in the Proposal, KBI Biopharma shall have no obligation to perform such supplemental services unless and until a Change Order is executed in accordance with Article 8 below, or unless the Parties agree in writing
on a proposal for additional services to be performed under this Agreement. 

  

	1.2	Additional Services. The Parties may agree upon additional Services to be performed under the terms of this Agreement, as may be described in purchase orders or Proposals to be mutually agreed upon by the Parties
in writing. 

  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	1.3	Compliance with Laws. As applicable to the Services, KBI Biopharma shall perform the Services in all material aspects in compliance with current cGMP and other rules, regulations and guidelines of the U.S. Food
and Drug Administration (“FDA”), as then in effect, applicable to the performance of the Services, including without limitation, those governing the manufacture, testing and quality control of investigational drugs. For
purposes of the foregoing, “cGMP” means the current Good Manufacturing Practices as promulgated under each of the following as in effect on the date of this Agreement and as amended or revised after the date of this Agreement
and in effect at the time of the performance of the Services: (a) the U.S. Food, Drug & Cosmetics Act (21 U.S.C. § 301 et seq.) and related U.S. regulations, including 21 Code of Federal Regulations
(Chapters 210 and 211) and (b) the ICH guide Q7 “ICH Good Manufacturing Practice Guide for Active Pharmaceutical Ingredients” as applied to investigational drugs (Section 19). Client shall have responsibility for determining
regulatory strategy and for all regulatory decisions except for those matters that KBI Biopharma, in its reasonable discretion deems contrary to regulatory requirements or commitments made by KBI Biopharma to regulatory authorities, of which matters
KBI Biopharma shall promptly notify Client in writing. Should the U.S. government regulatory requirements change, KBI Biopharma will use reasonable best efforts to satisfy the new requirements. Notwithstanding the foregoing, in the event that
compliance with such new U.S. regulatory requirements necessitates a change in the scope or nature of the Services to be completed, KBI Biopharma will submit to Client a Change Order in accordance with Article 8. 

 

	2.	Client Obligations 

  

	2.1	General. Unless otherwise agreed to by the Parties in writing, in each case in accordance with the Proposal, Client is solely responsible for, and performance hereunder by KBI Biopharma is contingent upon:
(a) to the extent Client is required to provide data under a Proposal regarding the product which is the subject of the Proposal (the “Product”) Client shall provide such data, which shall be complete and accurate;
(b) to the extent Client is required pursuant to a Proposal to transfer its methods to KBI Biopharma, provision of all information necessary to effect the reliable transfer of such methods to KBI Biopharma; (c) provision of specific
reagents, reference standards or other materials (“Client Materials”) to the extent it is required pursuant to a Proposal and necessary for execution of Services; (d) to the extent the Proposal requires Client’s
review and approval of in-process and/or finished product test results to ensure conformity of such results with required Product specifications Client shall not unreasonably withhold or delay such approval; (e) preparation of all submissions
to regulatory authorities; and (f) performance of all other obligations of Client set forth in the Proposal. Client shall perform its obligations as set forth in this Agreement, and reasonably cooperate with the execution of the Services and
shall not engage in any act or omission, which may reasonably be expected to prevent or delay the successful execution of the Services. Such support and cooperation shall include, but not be limited to, reasonably informing KBI Biopharma of global
regulatory strategy for development and approval of the Product (to the extent such strategy is reasonably necessary to perform the Services), 

  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

	 	
review and approval or rejection of documents requiring Client’s signature without unreasonable delay, timely delivery of methods and materials (to the extent delivery of such methods and
materials is contemplated by the Scope and reasonably necessary for KBI Biopharma to perform the Services) and response to other similar issues without unreasonable delay. 

 

	2.2	Provision of Regulatory Submissions. Prior to making any submission for regulatory approval of the Product, upon the request of KBI Biopharma, Client shall provide copies of the portions of regulatory submissions
that solely relate to KBI Biopharma’s manufacturing procedures (if applicable to the Services) to KBI Biopharma for review and opportunity to comment. 

  

	2.3	Information Regarding Hazardous Materials. Client shall provide to KBI Biopharma, on an on-going basis throughout the Term (as defined below), any applicable safe handling instructions for any Client Materials as
soon as is commercially practicable prior to delivery of any such Client Materials to KBI Biopharma. Where appropriate or required by law, Client shall provide a Material Safety Data Sheet and instructions for proper storage for all Client-provided
materials, finished product and reference standards. Client shall notify KBI Biopharma in writing of the possibility of cross contamination of any products being manufactured or stored by KBI Biopharma. KBI Biopharma shall safely store and handle
Client Materials in accordance with information provided to it by Client. KBI Biopharma shall be solely responsible for implementing and maintaining health and safety procedures for the Client Materials, taking into account the information provided
to KBI Biopharma. 

  

	2.4	Client Materials. All property rights in the Client Materials supplied to KBI Biopharma shall remain vested in Client. KBI Biopharma shall at all times use reasonable efforts to keep the Client Materials secure
and safe from loss or damage. Subject to the limitations of liability set forth in Section 11, KBI Biopharma shall be liable for loss or damage to Client Materials resulting from its negligence or intentional misconduct. Client grants KBI
Biopharma the right to use the Client Materials solely to the extent required to perform the Services. KBI Biopharma shall use the Client Materials only for the purpose of performing the Services and shall not subject the Client Materials to any
analysis or use inconsistent with the Services. In no event shall KBI Biopharma use Client Materials for its own benefit or in connection with the performance of services for third parties. 

 

	3.	Performance 

  

	3.1	Schedule. Due to the unpredictable nature of biological processes, the timelines and schedules for the performance of the Services (including without limitation the dates for production and delivery of Product)
and the yield or quantity of Product as set out in the Proposal are estimates only, provided, that in any and all events KBI Biopharma shall (i) use commercially reasonable efforts to meet the timelines, schedules, yields and quantities, and
(ii) use commercially reasonable efforts to mitigate the adverse effects of 

  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

	 	
any failure to meet the timelines, schedules, yields and quantities. KBI Biopharma shall keep Client regularly informed in writing of any such changes that are necessary to the Proposal, and
agrees that such changes will be made to the minimum extent reasonably necessary. 

  

	3.2	Technical Difficulties. 

  

	    	If it becomes apparent to either KBI Biopharma or Client at any stage in the provision of any Services that, as a result of scientific or technical reasons out of the reasonable control of either Party, it will not be
possible to complete the Services in the manner described in this Agreement or the Proposal or any Change Order thereto, the Parties will (a) identify the problem, (b) submit the problem in writing to senior management of each Party, and
(c) negotiate in good faith for a sixty (60) day period from the date senior management of the Parties first convene regarding how to resolve such problem in a commercially reasonable manner. 

 

	3.3	Quality Agreement. Contemporaneously with the execution of this Agreement, or as soon as practicable after the execution hereof, in the event that the Proposal specifically enumerates Services that include the
performance of activities that are subject to cGMP, the Parties shall develop and agree upon a quality agreement describing the regulatory and compliance roles and responsibilities of each Party, including without limitation, procedures for handling
Product recalls and non-conforming Product, the format and content of which shall be agreed upon by the Parties (the “Quality Agreement”). Upon execution by both Parties, the Quality Agreement shall be incorporated herein and
attached hereto as Attachment Two. 

  

	3.4	Non-Conforming Services. Within thirty (30) days of delivery of any deliverable in connection with the Services (“Deliverable”), Client shall inform KBI Biopharma of any material
non-conformity with (i) the specifications (the “Specifications”) set forth in the Proposal, the Quality Agreement or otherwise mutually agreed upon in writing and (ii) the requirements of this Agreement ((i) and
(ii) are collectively, the “Product Requirements”). Any failure of a Deliverable to meet the Product Requirements due to causes which are reasonably within KBI Biopharma’s control shall be deemed a
“Defective Deliverable”). As Client’s sole and exclusive remedy for a Defective Deliverable, KBI Biopharma shall, subject to Client providing the replacement active pharmaceutical ingredient or other source materials, as
applicable, promptly re-perform such non-conforming Services and deliver a replacement Deliverable that meets the Product Requirements with no additional fees to Client. A Deliverable shall be deemed “Accepted” upon the earlier of
(a) Client delivering written notice to KBI Biopharma that the Deliverable meets the applicable Specifications and Product Requirements or (b) Client failing to notify KBI Biopharma of a Defective Deliverable within the applicable thirty
(30) day period specified in this Section 3.4. 

  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

	4.	Work Output 

  

	    	All reports specified in the Proposal and other applicable cGMP documentation (“Work Output”) will be prepared using KBI Biopharma’s standard format(s) (which shall be commercially
reasonable) unless otherwise specified in the Proposal or this Agreement. Client will be supplied with copies of Work Output generated as a result of the Services as set forth in the Proposal or Quality Agreement Unless otherwise required by law,
KBI Biopharma shall maintain records related to each Proposal, including, but not limited to the Services, accounting records, time sheets, written policies and procedures, test results, reports, correspondence, memoranda and any other documentation
relating to the performance of its obligations under to this Agreement (“Records”). KBI Biopharma shall, during normal working hours, and with reasonable advance notice, permit Client or its authorized agents to inspect,
audit and/or reproduce Records (i) to the extent necessary to adequately evaluate invoices submitted to Client by KBI Biopharma hereunder, (ii) as required by governmental authorities or (iii) as desired by Client for any other valid
business purpose related to this Agreement. Vendor shall make appropriate personnel or other representatives available to Client and its agents to discuss Records and to resolve any questions or issues relating thereto. Such audits shall not be
conducted more frequently than once per year. 

  

	    	KBI Biopharma shall maintain all information and data generated by it in the course of providing the Services, including all Work Output, computerized records and files, in a secure area reasonably protected from fire,
theft and destruction. To the extent not delivered prior to the expiration or termination of this Agreement, at the expiration or termination of this Agreement and upon the written request of Client, all Records, data, information and tangible
property obtained or generated by KBI Biopharma in the course of providing the Services or arising out of the use of Client’s Confidential Information (collectively, “Results”) shall, at Client’s option, be (a) delivered to
Client at any address as Client may specify in such request, or (b) retained by KBI Biopharma for a period of five (5) years from the completion of the Services or such longer period required by applicable laws and regulations. Client
shall reimburse KBI Biopharma for the reasonable, documented cost of deliveries to Client under this Section 4. In no event shall KBI Biopharma dispose of any Results without first giving Client sixty (60) days’ prior written notice
of its intent to do so. 

  

	5.	Facility Visits and Audits 

  

	5.1	Scope of Visit. Client shall have the right upon no less than fifteen (15) business days’ prior written notice to KBI Biopharma and during regular business hours, to visit KBI Biopharma (i.e., person in
the plant) to observe the progress of the Services and to inspect related records and data for the purpose of making quality control inspections so as to assure compliance with this Agreement. The form, participants, duration and procedures of all
visits shall be subject to KBI Biopharma’s approval, which approval shall not be unreasonably withheld and shall be provided by KBI Biopharma within five (5) business days of Client’s notice of the visit. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	5.2	Client Obligations. It shall be the duty of Client to provide for the safety of, and prevention of accident or injury to, Client, its employees, agents, representatives, and guests of any of them while in, on or
about KBI Biopharma’s premises. KBI Biopharma also wants to ensure that all visits are conducted in a manner reasonably required to protect the confidentiality of KBI Biopharma Confidential Information and the confidential information of other
clients. As such, Client agrees that it and its subcontractors, employees, agents, representatives, and guests of any of them shall: (a) be subject to a nondisclosure obligation comparable in scope to Article 13, (b) follow
commercially reasonable security and facility access procedures as are designated by KBI Biopharma, (c) be accompanied by a KBI Biopharma representative, (d) not enter areas of any KBI Biopharma facility at times when any third
party’s products are being manufactured to assure protection of KBI Biopharma’s or third party’s confidential information (provided that to the extent Client’s products or deliverables hereunder are manufactured in such areas,
Client may schedule another visit at a time when the area where such products or deliverables are manufactured is accessible), (e) stay within the confines of KBI Biopharma’s facilities and shall not visit areas of the facility other than
those areas necessary for the performance of the facility visit provided for herein without KBI Biopharma’s prior written permission, and (f) use good faith efforts to avoid disrupting KBI Biopharma’s operations. All information
learned, observed or obtained by Client during any visit to KBI Biopharma’s facilities, excluding information regarding Client’s products, Client Materials and Results, shall be deemed “Confidential Information” of KBI Biopharma
under Article 13, regardless of whether such information is marked “Confidential” or subsequently summarized in writing. Client warrants that it, and to its knowledge, its subcontractors, employees, agents, representatives, and any
personnel acting on behalf of Client hereunder who visit the KBI Biopharma facility are not debarred, under subsections 306(a) or (b) of the Generic Drug Enforcement Act of 1992, as each may be amended from time to time,. 

 

	5.3	Costs. Client may conduct one (1) such quality assurance facility visit per calendar year at no cost to Client. Additional audits will be invoiced separately on a time and materials basis at the then current
rate for such services, provided, however, that if any visit by Client reveals noncompliance with the terms of this Agreement or the Quality Agreement, Client may conduct additional audits during such year at no cost. 

 

	6.	Regulatory Inspections 

  

	6.1	General. KBI Biopharma will promptly notify Client of any regulatory inspections directly relating to the Services, in accordance with the terms of the Quality Agreement (if applicable). KBI Biopharma shall
promptly rectify any deficiencies discovered during such inspections, audits and investigations of which KBI Biopharma is notified. KBI Biopharma agrees to reasonably cooperate with all regulatory authorities and submit to reasonable inspections by
such authorities. 

  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	6.2	Costs. Client shall be responsible for, and shall (i) promptly pay, all documented costs charged by a regulatory authority for inspections that arise solely out of Client’s product to be manufactured
under the Proposal and (ii) reimburse KBI Biopharma for its reasonable, documented out-of-pocket costs incurred by it in connection with such regulatory inspection. For the avoidance of doubt, Client shall not be responsible for costs
associated with inspections relating to KBI Biopharma’s or any third parties’ products, facilities, policies, procedures or manufacturing processes. 

  

	7.	Compensation 

  

	7.1	Fees. In consideration for KBI Biopharma performing the Services, Client shall pay to KBI Biopharma such amounts as described in the Price and Payment Terms section of the Proposal and as otherwise described in
this Agreement. The Parties agree and acknowledge that the Proposals will incorporate compensation terms generally consistent with the terms outline (the “Terms Outline”) attached to this Agreement as Attachment Three, as
applicable. It is further agreed by the Parties that references in the Terms Outline to a Program 1 shall apply to Aeglea’s Arginase program, and that references in the Terms Outline to a Program 2 shall apply to Aeglea’s
Cystinase program. To the extent there is any conflict between this Agreement and the Terms Outline, this Agreement shall govern. 

  

	7.2	Equity Component of Service Fees. Certain portions of the service fees (the “Equity Component”) under the applicable Proposals will be paid for in the form of the issuance of shares of Aeglea
BioTherapeutics Holdings, LLC (“Aeglea Holdings”) as described below. The Equity Component will be paid as follows: 

  

	    	7.2.1 For Stage 1 of Program 1 (corresponding to enabling Phase I studies for Arginase) and Stage 1 of Program 2 (corresponding to process development for Cystinase), a number of Preferred A
Shares of Aeglea Holdings shall be issued to KBI Biopharma calculated as set forth in the table below, provided further that all shares of Aeglea Holdings issued to KBI Biopharma shall be subject to the Share Return Right in Section 7.2.7
below. 

  

			
	Program 1, Stage 1		
	Service Fees Under Current Proposals		$[***]
	Service Fees Discount Percentage Under Current Proposals		[***]%
	Percentage of Cash Component		[***]%
	Percentage of Equity Component		[***]%
	Value of Shares to Be Issued		$[***]
	 Number of Preferred A Shares to Be Issued @

$[***] per share
		[***] Preferred A Shares
		
	Program 2, Stage 1		

  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

			
	Service Fees Under Current Proposals	  	$[***]
	Service Fees Discount Percentage Under Current Proposals	  	[***]%
	Percentage of Cash Component	  	[***]%
	Percentage of Equity Component	  	[***]%
	Value of Shares to Be Issued	  	$[***]
	 Number of Preferred A Shares to Be Issued @

$[***] per share
	  	[***] Preferred A Shares
		
	Total Value of Preferred A Shares to be Issued for Program 1, Stage 1 and Program 2, Stage 1	  	$[***]
		
	Total Preferred A Shares to be Issued (at a purchase price of $[***] per share)	  	[***] Preferred A Shares

 For Program 1 Stage 1, the Preferred A Shares shall be issued as follows: 

 

					
	 Percentage of Shares
	  	Event	 
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  
		  	 	[***]	  
	 [***]
	  	 	[***]	  

 The value of the equity payment shall be credited against invoiced amounts. 

For Program 2 Stage 1, the Preferred A Shares shall be issued as follows: 
  

					
	 Percentage of Shares
	  	Event:	 
	 [***]
	  	 	[***]	  
	 [***]
	  	 	[***]	  

 The $[***] in services value of the first equity payment for Program 2 shall be credited against invoiced
amounts. The next $[***] in invoiced amounts shall be paid in cash. The $[***] in services value of the second equity payment shall be next credited against invoiced amounts. In the event that Aeglea Holdings issues a new series of preferred shares
other than Preferred A Shares prior to the issuance of any Preferred A Shares as required above (“New Round Securities”), then in lieu of Preferred A Shares, KBI shall be issued a number of New Round Securities equal to the corresponding
equity value set forth above with respect to such Preferred A Shares (determined by reference to the Preferred A Share original purchase price of $[***] per share) divided by the price per share of the New Round Securities. 

7.2.2 For all other Services for which the Parties have agreed to compensation which includes an Equity Component, the applicable amount of the
Equity Component shall be 
  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

 
issued to KBI Biopharma for each stage (including Program 1, Stage 2; Program 2, Stage 2; and optional Program 3, Stages 1 and 2) (each a
“Stage”), pursuant to the applicable Proposal or other written agreement of the Parties. All such shares of Aeglea Holdings issued to KBI Biopharma shall be subject to the Share Return Right in Section 7.2.7 below. 

7.2.3 Each portion of the Equity Component not issued pursuant to Section 7.2.1 above shall be compensated by issuance to KBI Biopharma
of the agreed value of shares in the then current series and valuation of preferred shares of Aeglea Holdings in a manner agreed upon by KBI Biopharma and Client. The Parties acknowledge that, depending on the date of initiation of KBI
Biopharma’s Services for subsequent Stages, this may result in KBI Biopharma receiving a subsequently created, authorized and issued class of preferred shares for such subsequent Stage. 

7.2.4 Client shall ensure that Aeglea Holdings allocates [***] shares of Preferred A Shares to be potentially issued to KBI Biopharma pursuant
to Section 7.2.1 in order to satisfy the anticipated amounts of the Equity Component under Section 7.2.1 (the “KBI Allocated Shares”). 

7.2.5 In the event that the Parties agree on Modifications to the Services, pursuant to Article 8 hereunder, that would require payment
of an additional amount of Equity Component, such additional amount of Equity Component shall be paid by either (a) issuance to KBI Biopharma of the agreed value of shares in the then current series and valuation of preferred shares of Aeglea
Holdings, if KBI Allocated Shares remain available for issuance; or (b) payment to KBI Biopharma of the agreed amount in cash if all applicable KBI Allocated Shares have been previously issued to KBI. 

7.2.6 Upon the issuance of the first installment of any Equity Component, KBI Biopharma shall execute a signature page to and become party to
and bound by the Aeglea Holdings Limited Liability Company Agreement, as amended and restated from time to time (the “Aeglea LLC Agreement”) with respect to the issued shares. The shares received for the Equity Component by
KBI Biopharma shall have the same respective rights, preferences and privileges, and subject to same obligations, pursuant to the Aeglea LLC Agreement as the other preferred shares issued to investors; provided that KBI Biopharma shall not have any
rights to elect members to the Aeglea Holdings Board of Directors (but KBI Biopharma shall have the right to appoint an observer to the Board meetings. All shares issued to KBI BioPharma as part of the Equity Component shall be issued pursuant to a
form of subscription agreement in the form of agreement attached hereto as Attachment Four. 
 7.2.7 In the event that Client terminates
this Agreement or a Proposal pursuant to Section 25.3 or Section 25.4, the portion of any shares of Aeglea Holdings which was issued to KBI Biopharma for Services which were either not performed or were performed in a manner which gave
rise to Client’s right to terminate for breach shall be 
  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

 
automatically cancelled and KBI Biopharma shall return the share certificate for such cancelled shares to Client and upon Client’s receipt of the share certificate for such cancelled shares
Aeglea Holdings shall issue a new share certificate to KBI Biopharma for any shares not cancelled(hereinafter, the “Share Return Right”). 
  

	7.3	Payment of Cash Component of Service Fees and Materials. Certain portions of the service fees under the applicable Proposals, other than the Equity Component, and the cost of materials will be paid for by Client
in cash (the “Cash Component”). The Cash Component shall be invoiced and paid as set forth below. 

  

	7.4	Invoices for Cash Component. Following payment of any initial fee as provided in Section 7.5 subject to Section 7.2.1 for Proposals related to Program 1, Stage 1 and Program 2,
Stage 2, the remainder of the service fees for the Cash Component will be billed by KBI Biopharma in semi-monthly invoices based on a billing schedule derived from the project schedule. Payments are due thirty (30) days from date of the
undisputed invoice, except as specifically provided in this Agreement. Invoices shall not be dated earlier than the date sent to Client. If KBI is required to purchase material on behalf of client, such material shall be deemed “Client
Materials” and charges for materials will be invoiced to Client and are payable at the time that KBI Biopharma orders such materials for Client’s project. Client agrees to pay to KBI Biopharma the cost for such Client Materials specified
in the Proposal, including any handling fees which may be agreed upon by the Parties in the Proposal. Undisputed late payments are subject to an interest charge of one and one percent (1%) per month or, if less, the maximum legal interest rate
per month. Failure to bill for interest due shall not be a waiver of KBI Biopharma’s right to charge interest. All payments are non-refundable. If paid by wire transfer, any applicable wire transfer fees must be included in the payment issued
to KBI Biopharma. Unless within thirty (30) days of the date of invoice, Client has advised KBI Biopharma, in good faith and in writing the specific basis for disputing an invoice, Client’s failure to promptly pay an invoice may, at KBI
Biopharma’s election, and notwithstanding the provisions of Section 25.3, constitute a material breach of this Agreement. 

  

	7.5	Start-up Payment. For Proposals without an Equity Component, KBI Biopharma requires payment of an initial fee of one third of the Cash Component portion of the service fees specified in the Proposal, prior to
commencement of Services, to account for facilities preparation costs and resource allocation commitments with respect to Client’s project(s). Initial fees are due upon execution of this Agreement or the applicable Proposal, whichever occurs
later. The initial fee shall be applied on a one-third pro rata basis to the invoices in the order received. As an example, a charge of $3,000 would be satisfied by application of $1,000 from the existing initial fee balance and an additional
payment by Client of $2,000. Upon termination of a Proposal or this Agreement, any remaining portion of the initial fee shall be applied to any outstanding amounts due from Client under the applicable Proposal. Unless otherwise provided in this
Agreement or the applicable Proposal, initial fees are non-creditable, nonrefundable, non-transferable to apply to any Services other than under the applicable Proposal. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	7.6	Client Delays. KBI Biopharma has allocated resources to the Services that may be difficult or impractical to reallocate to other programs in the event of a delay attributable to Client’s material failure to
comply with its obligations under this Agreement or Client’s written request for delay. In recognition of this, in the event that KBI Biopharma is unable to reasonably reallocate such resources, the Parties shall negotiate in good faith
regarding how to address the delay in a commercially reasonable manner. 

  

	7.7	Taxes. Any federal, state, county or municipal sales or use tax, excise tax, customs charges, duties or similar charge, or any other tax assessment (other than that assessed against KBI Biopharma’s income),
license, fee or other charge lawfully assessed or charged on the manufacture, sale or transportation of Product sold or Services performed pursuant to this Agreement, and all government license filing fees and, if applicable, Prescription API User
(PDUFA) annual establishment fees with respect to all Products and Services shall be paid by Client. 

  

	8.	Change Orders 

  

	8.1	Change Orders. The assumptions relating to the completion of the Services are set forth in the Proposal (“Proposal Assumptions”). KBI Biopharma also assumes that Client will perform its
obligations under this Agreement and the Proposal as set forth herein, that no Force Majeure Event will occur, and that there are no changes to any applicable laws, rules or regulations relating to and materially affecting the performance of the
Services (the foregoing assumptions together with the Proposal Assumptions, collectively, the “Assumptions”). In the event of a material failure of any of the Assumptions that directly and adversely affects KBI
Biopharma’s ability to perform the Services, then the scope of services to be performed shall be amended as provided in this Article 8 (a “Modification”). Modifications shall also arise in the event Client
(i) revises KBI Biopharma’s responsibilities, the specifications, the Proposal instructions, procedures, Assumptions, processes, test protocols, test methods, or analytical requirements or (ii) requests changes to the Proposal.

  

	8.2	Change Order Process. In the event a Modification is required pursuant to Section 8.1 and requested by Client or by KBI Biopharma, KBI Biopharma shall provide Client with a change order containing an
estimate of the required Modifications to the budget, activities and/or duration specified in the Proposal (“Change Order”). Client and KBI Biopharma shall negotiate in good faith for a period of ten (10) business days
following receipt of such Change Order by Client (the “Change Order Negotiation Period”) to agree on a Change Order that is mutually acceptable. If practicable, and agreed to by Client, KBI Biopharma shall continue work on
the Services during any such negotiations, but shall have no obligation to commence work with respect to any Change Order unless authorized in writing by Client. In the event the Parties are unable to agree upon such Change Order with respect to a
Modification within the Change Order Negotiation Period, KBI Biopharma or Client may elect to terminate this Agreement, or if reasonably possible, to perform the Services without regard to the unresolved Change Order; 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	 	
provided, however, that the estimated timelines shall be adjusted to reflect any delay during the Change Order Negotiation Period. In the event that this Agreement is so terminated, the
provisions with respect to the effect of termination set forth in Section 25.5 shall apply. Any disputes arising from this Section 8.2 shall be resolved in accordance with the dispute resolution procedures set forth in Article 23.

  

	8.3	Regulatory Changes. Notwithstanding the foregoing, with respect to any changes or modifications to the Proposal, Services or Product specifications dictated by the FDA or other applicable law or authority, Client
shall be responsible for the costs of making such changes (including without limitation capital costs), validating the manufacturing process after any such change is made, and any increases in the cost of manufacturing the Product or provision of
Services as a result of such change. With respect to any such changes dictated by the FDA or other applicable law or authority, the Parties will promptly meet to discuss the actions necessary to comply with such changes and the costs associated
therewith. 

  

	9.	Shipment 

  

	9.1	General. Unless otherwise agreed in writing by the Parties, all Deliverables, products, raw materials, samples components or other materials provided hereunder by KBI Biopharma shall be made available for
shipment Ex Works (INCOTERMS 2010) KBI Biopharma’s facilities. For purposes of clarification, Ex Works means that carriage of goods shall be arranged by Client, and the cost of such carriage and risk of loss shall transfer to Client when the
goods have been made available for shipment at KBI Biopharma’s facilities. KBI Biopharma shall package for shipment such product, raw materials, samples, components or other materials at Client’s expense (including insurance) and in
accordance with Client’s complete written and reasonable instructions. 

  

	9.2	Shipping Charges. Client shall pay to KBI Biopharma, in addition to actual shipping costs, a handling fee of either (i) One Hundred Dollars ($100) for each standard shipment, or (ii) One Thousand
Dollars ($1,000) for each expedited shipment (i.e., shipment made available in less than forty-eight (48) hours from request by Client). 

  

	10.	Notices 

 Any notice required to be given pursuant to the terms and provisions hereof shall be in writing
and shall be sent by certified or registered mail, postage prepaid with return receipt requested, or by nationally recognized overnight courier, postage prepaid with return receipt requested, or by confirmed facsimile (with printed confirmation of
receipt), to the other Party at the following address: 
 If to Client: 

Aeglea Development Company, Inc. 815-A Brazos St #101 

Austin, TX 78701 
 Attention:
David G. Lowe 
  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

 If to KBI Biopharma: 

KBI Biopharma, Inc. 
 1101 Hamlin
Road 
 Durham, North Carolina 27704 

Attention: George Elston, Senior Vice President and CFO 

with a copy to the Vice President and General Counsel, at the same address. 

Each notice shall be deemed sufficiently given, served, sent, or received for all purposes at such time as it is delivered to the addressee or at such time as
delivery is refused by the addressee upon presentation. 
  

	11.	Limitations of Liability 

 Notwithstanding anything herein to the contrary, except as set forth below,
each Party’s total liability for any loss suffered by the other Party resulting from this Agreement, shall be limited to the payment of damages which shall not exceed the price for Services payable by Client to KBI Biopharma under the Proposal.
The foregoing limitation shall not apply to breaches of Section 13, and shall not limit either Party’s obligations under Section 15. 

EXCEPT AS PROVIDED BELOW IN THIS PARAGRAPH, NEITHER PARTY SHALL BE LIABLE TO THE OTHER PARTY FOR ANY INCIDENTAL, INDIRECT, PUNITIVE, CONSEQUENTIAL
(INCLUDING WITHOUT LIMITATION, LOST PROFITS), EXEMPLARY OR SPECIAL DAMAGES OF ANY TYPE, ARISING IN CONNECTION WITH THIS AGREEMENT, THE PROPOSAL, THE QUALITY AGREEMENT OR ANY ATTACHMENTS OR DOCUMENTS RELATED THERETO, WHETHER OR NOT FORESEEABLE AND
WHETHER SUCH DAMAGES ARISE IN TORT, CONTRACT, EQUITY, STRICT LIABILITY, OR OTHERWISE, EVEN IF THE PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. The foregoing limitation shall not apply to breaches of Section 13, and shall not
limit either Party’s obligations under Section 15 
  

	12.	Warranties 

  

	12.1	Warranties of KBI Biopharma. 

  

	    	12.1.1 As of the Effective Date, KBI Biopharma represents and warrants to Client that it has all requisite corporate power and authority to enter into and perform all of its obligations under this Agreement. The
execution and delivery of this Agreement and the consummation of the transactions contemplated hereby have been duly and validly authorized by all necessary corporate action in respect thereof on the part of KBI 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	 	
Biopharma. Neither the execution and delivery of this Agreement nor the performance of the transactions contemplated hereby, nor compliance by KBI Biopharma with the provisions hereof, shall
conflict with any obligations or agreements of KBI Biopharma to any person, contractual or otherwise. 

 12.1.2 KBI Biopharma
warrants to Client that it will render the Services with due care, consistent with industry standards for work of a similar nature. 

12.1.3 KBI Biopharma represents, warrants and covenants to Client that, except to the extent provided in the Proposal, KBI Biopharma will not,
to its knowledge, use the property of any third party in performing the Services. KBI Biopharma represents, warrants and covenants that Client will receive good title to Results without any liens or encumbrances. KBI Biopharma represents and
warrants to Client that to KBI Biopharma’s knowledge, KBI Biopharma’s performance of the Services will not violate or infringe on the patents, trademarks, service marks, copyrights, or intellectual property of any nature of any third
party. 
 12.1.4 KBI Biopharma represents and warrants to Client that it will hold, use and/or dispose of Client Materials in accordance
with all applicable laws, rules and regulations. 
 12.1.5 KBI Biopharma represents to Client that it is not debarred, and warrants to
Client that it will not knowingly use in any capacity the services of any person debarred, under subsections 306(a) or (b) of the Generic Drug Enforcement Act of 1992, as each may be amended from time to time. 

12.1.6 EXCEPT AS EXPRESSLY WARRANTED IN THIS SECTION 12.1, KBI BIOPHARMA MAKES NO REPRESENTATION OR WARRANTY WITH RESPECT TO THE SERVICES OR
PRODUCT, EXPRESS OR IMPLIED, IN ANY MANNER AND EITHER IN FACT OR BY OPERATION OF LAW, AND SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED OR STATUTORY WARRANTIES, INCLUDING, WITHOUT LIMITATION, ANY WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE, COURSE OF DEALING, COURSE OF PERFORMANCE, USAGE OF TRADE OR NONINFRINGEMENT. KBI BIOPHARMA MAKES NO WARRANTIES THAT THE EXECUTION OF THE SERVICES WILL RESULT IN ANY SPECIFIC QUANTITY OR AMOUNT OF PRODUCT. 

 

	12.2	Warranties of Client. 

 12.2.1 As of the Effective Date, Client represents and warrants
to KBI Biopharma that it has all requisite corporate power and authority to enter into and perform all of its obligations under this Agreement. The execution and delivery of this Agreement and the consummation of the transactions contemplated hereby
have been duly and validly authorized by all necessary corporate action in respect thereof on the part of Client. 
  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

 
Neither the execution and delivery of this Agreement nor the performance of the transactions contemplated hereby, nor compliance by Client with the provisions hereof, shall conflict with any
obligations or agreements of Client to any person, contractual or otherwise. 
 12.2.2 Client represents and warrants to KBI Biopharma that
it holds legal title to, or is fully entitled to provide, the materials, methods, plans, processes and other intellectual property necessary to conduct the Services and that, to Client’s knowledge, KBI Biopharma’s performance of the
Services will not violate or infringe on the patents, trademarks, service marks, copyrights, or intellectual property of any nature of any third party. 

12.2.3 Client represents and warrants to KBI Biopharma that, to its knowledge, the materials provided by Client for use in the performance of
the Services are free of material defects and contaminants. 
 12.2.4 Client represents and warrants to KBI Biopharma that it will hold, use
and/or dispose of Product delivered to it hereunder and all materials provided by KBI Biopharma in accordance with all applicable laws, rules and regulations. 
  

	13.	Confidentiality 

  

	13.1	Confidential Information. During the Term and for a period of five (5) years thereafter, each Party shall maintain in confidence all information and materials of the other Party disclosed or provided to it
(the “Recipient”) by the other Party (the “Disclosing Party”) including the terms and conditions (but not the existence) of this Agreement (together with all embodiments thereof, the
“Confidential Information”); provided, however, (a) information need not be labeled or marked “confidential” to be deemed Confidential Information hereunder, if under the circumstances it is, or should be,
understood to be confidential; and (b) in accordance with Section 5.2, information learned, observed or obtained by Client during any visit to KBI Biopharma’s facilities shall to the extent provided in Section 5.2 hereof, be
deemed “Confidential Information” of KBI Biopharma hereunder, regardless of whether such information is marked “confidential” or subsequently summarized in writing. Notwithstanding anything to the contrary herein, Results and
information regarding Client Materials, Client Inventions (as defined in Section 14.1), and Client’s business, scientific, research, and development plans shall be deemed Client’s Confidential Information regardless of whether such
information is marked “confidential” or subsequently summarized in writing, with respect to which, Client shall be the Disclosing Party and KBI Biopharma the Recipient. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	13.2	Exceptions. Notwithstanding the foregoing, Confidential Information shall not include that portion of information or materials that the Recipient can demonstrate by contemporaneous written records was:

  

	 	(i)	known to the general public at the time of its disclosure to the Recipient, or thereafter became generally known to the general public, other than as a result of actions or omissions of the Recipient in violation of
this Agreement; 

  

	 	(ii)	disclosed to the Recipient on an unrestricted basis from a source unrelated to the Disclosing Party and not known by the Recipient to be under a duty of confidentiality to the Disclosing Party, as evidenced by competent
written proof; or 

  

	 	(iii)	independently developed by the Recipient, or known by the Recipient prior the date of disclosure by the Recipient, without the use of Confidential Information of the Disclosing Party, as evidenced by competent written
proof. 

  

	13.3	Additional Protections. Each Party shall take all reasonable steps to maintain the confidentiality of the Confidential Information of the other Party, which steps shall be no less protective than those that such
Party takes to protect its own information and materials of a similar nature, but in no event less than a reasonable degree of care. Neither Party shall use or permit the use of any Confidential Information of the other Party except for the purposes
of carrying out its obligations or exercising its rights under this Agreement. All Confidential Information of a Party, including all copies and derivations thereof, is and shall remain the sole and exclusive property of the Disclosing Party and
subject to the restrictions provided for herein. Neither Party shall disclose any Confidential Information of the other Party other than to those of its directors, officers, employees, licensors, independent contractors, assignees, agents and
external advisors directly concerned with the carrying out of this Agreement, on a strictly applied “need to know” basis, provided that any such disclosure is made subject to obligations of confidentiality no less stringent than the
obligations provided herein. 

  

	13.4	Permitted Disclosures. The obligations set forth in this Article 13 shall not apply to the extent that Recipient is required to disclose information by law, judicial order by a court of competent jurisdiction, or
the rules of a securities exchange or requirement of a governmental agency for purposes of obtaining approval to test or market Product, or disclosures of information to a patent office for the purposes of filing a patent application as permitted in
this Agreement; provided, however, that the Recipient shall provide prior written notice thereof to the Disclosing Party and sufficient opportunity for the Disclosing Party to review and comment on such required disclosure and request confidential
treatment thereof or a protective order therefore. Any disclosure permitted pursuant to this Section 13.4 shall not be considered an exception under Section 13.2. 

 

	13.5	Injunctive Relief. The Parties acknowledge that either Party’s breach of this Article 13 may cause the other Party irreparable injury for which it may not have an adequate remedy at law. In the event of a
breach, the non-breaching Party shall be entitled to seek injunctive relief in addition to any other remedies it may have at law or in equity, in accordance with Article 23. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	14.	Inventions 

  

	14.1	Inventions. Client shall own (i) any and all Results, (ii) all ideas, developments, inventions, methods, technology, know-how, improvements, techniques generated or created by KBI Biopharma or its
employees, directors, officers, subcontractors, consultants, agents and representatives (“Representatives”) in the performance of the Services or as a result of access to or use of Client Materials or Client’s
Confidential Information whether independently or jointly with one or more employees of Client or others and (iii) all intellectual property rights associated with the foregoing items (i) and (ii), including, without limitation,
copyrights, trade secrets, inventions, whether patentable or not, ((i), (ii) and (iii) are collectively, “Client Inventions”). KBI Biopharma hereby assigns to Client all right, title and interest in and to Client
Inventions without any lien, claim or encumbrance. Notwithstanding the foregoing, KBI Biopharma shall retain all rights to any data, ideas, information, developments, inventions, or know- how relating to general manufacturing and analytical methods
and processes developed, conceived or reduced to practice in connection with the Services that (i) can be generally applied to the production of biologics other than the Product and (ii) are not derived from and do not contain or reference
Client’s Confidential Information (“Process Invention”). If Client requests and at Client’s expense, KBI Biopharma will execute any and all applications, assignments or other instruments and give testimony which
shall be necessary to apply for and obtain letters of patent of the US or of any foreign country with respect to the Client Invention and Client shall compensate KBI Biopharma for the time devoted to such activities (at commercially reasonable
rates) and reimburse it for reasonable, documented out-of-pocket expenses incurred. For Client Inventions assigned pursuant to this section, Client shall provide KBI Biopharma a royalty-free license to use such Client Inventions to the extent
necessary to perform the Services. KBI Biopharma shall not incorporate any intellectual property, inventions, technology, processes, methods or other property of KBI Biopharma into Client Inventions and Results (“Non-Client
Property”). To the extent KBI Biopharma does incorporate Non-Client Property into Client Inventions or Results, KBI Biopharma hereby grants Client a non-exclusive, perpetual, irrevocable, royalty-free, world-wide and transferable
license, with the right to sublicense, to use and exercise all such Non-Client Property and all associated patent rights, trade secret rights and other intellectual property rights for any purpose relating to Client’s and its sublicensee’s
use of the Client Inventions, Deliverables, Products, Results and derivatives thereof. No license fee shall be payable by Client for this license either during or after the term of this Agreement. 

 

	14.2	Process Inventions. KBI Biopharma hereby grants to Client a perpetual, irrevocable, fully-paid, royalty-free, world-wide and transferable non-exclusive license (with the right to sublicense through multiple tiers
of sublicensees) to use Process Inventions and exercise all associated patent rights, trade secret rights and other intellectual property 

  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

	 	
rights, to the extent necessary to make, have made, sell, offer for sale, use, import and otherwise commercially exploit Product, Deliverables, Client Inventions, Results and derivatives thereof.
If KBI Biopharma reasonably requests, and at KBI Biopharma’s expense, Client will execute any and all applications, assignments or other instruments and give testimony which shall be necessary to apply for and obtain letters of patent of the US
or of any foreign country with respect to the Process Inventions and KBI Biopharma shall compensate Client for the time devoted to such activities and reimburse it for expenses incurred. 

 

	14.3	KBI Biopharma Process Technology. Client acknowledges that KBI Biopharma, and KBI Biopharma’s personnel, possess and continuously update proprietary inventions, tools, templates, models, methodologies,
processes, know-how, trade secrets, improvements, and other intellectual properties and other assets, including but not limited to analytical methods, procedures and techniques, computer technical expertise and software, and business practices,
related to the development and commercialization of biopharmaceuticals, as well as other areas, which have been independently developed by KBI Biopharma and its personnel (collectively, “KBI Biopharma Process Technology”).
KBI Biopharma, and KBI Biopharma’s personnel, shall retain exclusive right, title and interest in and to all KBI Biopharma Process Technology and improvements thereto. 

 

	15.	Indemnification 

  

	15.1	Indemnification by KBI Biopharma. KBI Biopharma will indemnify, defend and hold harmless Client and its shareholders, directors, officers, employees and agents (each, a “Client
lndemnitee”) from and against all costs, losses, expenses (including reasonable attorneys’ fees) and direct damages (collectively, “Losses”) resulting from all lawsuits, claims, demands, actions and other
proceedings by or on behalf of any third party (collectively “Claims”) to the extent arising out of or resulting from: (i) K61 Biopharma’s material breach of any of its covenants, obligations or warranties
hereunder, or a failure of any material representation made hereunder by KBI Biopharma; or (ii) KBI Biopharma’s gross negligence or intentional misconduct, except in each case to the extent such Claims or Losses arise from negligence or
intentional misconduct on the part of a Client Indemnitee or a breach of this Agreement by Client. 

  

	15.2	Indemnification by Client. Client will indemnify, defend and hold harmless KBI Biopharma and its shareholders, directors, officers, employees and agents (each, a “KBI Biopharma
Indemnitee”) from and against all Losses resulting from all Claims to the extent arising out of or resulting from: (i) Client’s material breach of any of its covenants, obligations or warranties hereunder, or a failure of any
material representation made hereunder by Client; (ii) the development (including the conduct of clinical trials in humans), handling, manufacturing, testing, storage, transportation, disposal, marketing, commercialization (including any
recalls, field corrections or market withdrawals), distribution, promotion, sale or use by Client of the Product or of the results or performance of the Services (including without limitation as a result of any illness, injury 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	 	
or death to persons, including employees, agents or contractors of Client or damage to property); or (iii) Client’s gross negligence or intentional misconduct; except in each case to
the extent such Claims or Losses arise from negligence or intentional misconduct on the part of a KBI Biopharma Indemnitee or a breach of this Agreement by KBI Biopharma. 

 

	15.3	Indemnification Procedure. If any Claim covered by Article 15 is brought: 

 15.3.1
the indemnified Party shall promptly notify the indemnifying Party in writing of such Claim, provided, however, the failure to provide such notice within a reasonable period of time shall not relieve the indemnifying Party of any of its obligations
hereunder except to the extent the indemnifying Party is prejudiced by such failure or delay; 
 15.3.2 the indemnifying Party shall assume,
at its cost and expense, the sole defense of such Claim through counsel selected by the indemnifying Party and reasonably acceptable to the other Party, except that those indemnified may at their option and expense select and be represented by
separate counsel; 
 15.3.3 the indemnifying Party shall maintain control of such defense and/or the settlement of such Claim; 

15.3.4 the indemnified Party may, at its option and expense, participate in such defense, and if it so participates, the indemnifying Party
and the indemnified Party shall cooperate with one another in such defense; 
 15.3.5 the indemnifying Party will have authority to consent
to the entry of any settlement or otherwise to dispose of such Claim (provided and only to the extent that an indemnified Party does not have to admit liability and such judgment does not involve equitable relief), and an indemnified Party may not
consent to the entry of any judgment, enter into any settlement or otherwise to dispose of such Claim without the prior written consent of the indemnifying Party (not to be unreasonably withheld or delayed); and 

15.3.6 the indemnifying Party shall pay the full amount of any judgment, award or settlement with respect to such Claim and all other costs,
fees and expenses related to the resolution thereof; provided, however, that such other costs, fees and expenses have been incurred or agreed, as the case may be, by the indemnifying Party in its defense or settlement of the Claim. 

 

	16.	Force Majeure 

 Except for each Party’s payment, confidentiality and indemnity obligations, the
obligations of either Party under this Agreement shall be excused during each period of delay directly caused by matters such as acts of God, strikes, power failure, government orders, sufferance of acts of government or governmental regulation
(including without limitation, acts of the FDA or an applicable foreign equivalent), or acts of war or terrorism, which are reasonably beyond the 
  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

 
control of the Party obligated to perform (each, a “Force Majeure Event’). A Force Majeure Event shall not include a lack of funds, bankruptcy or other financial cause or
disadvantage. Nothing contained in this Agreement shall affect either Party’s ability or discretion regarding any strike and all such strikes shall be deemed to be beyond the control of such Party. A Force Majeure Event shall be deemed to
continue only so long as the affected Party shall be using its commercially reasonable effort to overcome such condition. If either Party shall be affected by a Force Majeure Event, such Party shall use commercially reasonable efforts to mitigate
the effects of the Force Majeure Event and shall give the other Party prompt notice thereof, which notice shall contain the affected Party’s estimate of the duration of such condition and a description of the steps being taken or proposed to be
taken to overcome such Force Majeure Event. If a Force Majeure Event continues for more than ninety (90) days, the Party whose performance is not affected by the Force Majeure Event shall have the right to terminate this Agreement, effective
upon notice to the other party. Any delay, or invalidity in the results delivered, in the performance of the Services occasioned by any such cause shall not constitute a default under this Agreement, and the obligations of the Parties shall be
suspended during the period of delay so occasioned. During any period of any Force Majeure Event, the Party that is not directly affected by such Force Majeure Event may take any reasonable action necessary to mitigate the effects of such Force
Majeure Event. If any part of the Services is invalid as a result of such disability, KBI Biopharma will, upon written request from Client, but at Client’s sole cost and expense, repeat that part of the Services affected by the Force Majeure
Event. 
  

	17.	Insurance 

  

	17.1	KBI Biopharma Insurance. KBI Biopharma shall secure and maintain in full force and effect throughout the Term policies of insurance for (a) workers’ compensation in accordance with applicable statutory
requirements, employer’s liability in an amount not less than $1,000,000, and automobile liability in an amount not less than $1,000,000, (b) commercial general liability in an amount not less than $2,000,000 per occurrence and $2,000,000
in the aggregate, and (c) products liability in an amount not less than $2,000,000 per occurrence and $2,000,000 in the aggregate. 

  

	17.2	Client Insurance. Client shall secure and maintain in full force and effect throughout the Term, and for a period of three (3) years after completion of any clinical trials in which any Product provided
under this Agreement is used, policies of insurance for (a) workers’ compensation in accordance with applicable statutory requirements, employer’s liability in an amount not less than $1,000,000, and automobile liability in an amount
not less than $1,000,000 and (b) primary and noncontributory commercial general liability in an amount not less than $1,000,000 per occurrence and $2,000,000 in the aggregate 

 

	18.	Independent Contractor; Non-Solicitation 

  

	18.1	Independent Contractor. KBI Biopharma shall perform the Services as an independent contractor of the Client. The relationship between the Parties shall not constitute a partnership, joint venture or agency nor
constitute either Party as the agent, employee or legal representative of the other. The Parties agree that neither shall have power or right to bind or obligate the other, nor shall either hold itself out as having such authority.

  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	18.2	Non-Solicitation. During the Term of this Agreement and for one (1) year thereafter, each Party agrees not to directly or indirectly solicit to hire or hire (in any capacity) any person who is an employee,
contractor, consultant or representative of the other Party; provided that newspaper, internet or other advertisements to fill job openings shall not be deemed to be “solicitation” hereunder. Any exceptions to this provision must be in
writing and signed by each Party and, for each person that is hired in such manner, the hiring Party shall compensate the other Party at the rate of 30% of such person’s annualized base salary. 

 

	19.	Publicity 

 The Parties may agree in writing to issue press releases or public disclosures describing the
general nature of the Services provided hereunder. The use of the name, trademark, logo, or other identifying materials of either Party or its employees in any publicity, advertising or promotional material shall require the other Party’s
express prior written consent. 
  

	20.	Use of Intellectual Property Rights 

 Except as expressly stated in this Agreement, no intellectual
property rights of any kind or nature are conveyed by this Agreement and neither Party shall have any right, title or interest in or to the other Party’s intellectual property rights for any purpose whatsoever without such other Party’s
prior written consent. 
  

	21.	Entire Agreement, Amendment, Construction, Precedence 

 This Agreement, the Proposal, and any applicable
Quality Agreement constitute the entire agreement between the Parties and supersede all prior and contemporaneous negotiations, representations, commitments, agreements and understandings between the Parties (whether written or oral) relating to the
subject matter hereof. This Agreement may not be amended or modified without the mutual written consent of both Parties. Each Party has had the opportunity to consult with counsel in connection with the review, drafting and negotiation of this
Agreement. Accordingly, the rule of construction that any ambiguity in this Agreement shall be construed against the drafting Party shall not apply. In the event of any conflict among the components of this Agreement, the following order of
precedence shall apply: (i) the terms and conditions of the Agreement, (ii) the Quality Agreement (if existing), and (iii) the Proposal. If Client chooses to issue a purchase order for the delivery of the Services or any component
thereof, such purchase order should reference this Agreement and shall be issued solely for the convenience of Client and to provide subject matter description; however, any legal terms and conditions contained therein shall be of no effect. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	22.	Choice of Law 

 This Agreement shall be construed and enforced in accordance with the laws of and in the
venue of the State of North Carolina, without regard to its, or any other jurisdiction’s, rules regarding conflicts or choice of laws. The Parties agree to and submit to the sole and exclusive jurisdiction of the North Carolina courts, both
state and federal. The Parties waive application of the provisions of the 1980 U.N. Convention on Contracts for the International Sale of Goods, as amended. 
  

	23.	Dispute Resolution 

  

	23.1	Initial Attempts to Resolve Disputes. If a dispute arises between the Parties in connection with this Agreement, the respective presidents or senior executives of KB’ Biopharma and Client shall first meet as
promptly as practicable and attempt to resolve in good faith such dispute. If such parties cannot resolve the dispute within thirty (30) days after written notice given by one Party to the other specifically invoking this stage in the dispute
resolution procedure, either Party may by written notice to the other commence the arbitration process set forth in Section 23.2 below. 

  

	23.2	Arbitration. If a dispute has not been resolved by negotiation as provided in Section 23.1 above, then, except as otherwise provided in this Section 23.2, the dispute will be finally settled by binding
arbitration in accordance with the Commercial Arbitration Rules of the AAA then in effect, by three (3) arbitrators, one of whom will be designated by each Party and the third of whom will be designated by the two so designated. The
arbitration, it shall be conducted in English and held in Durham, North Carolina. The arbitrators will render their award in writing and, unless all Parties agree otherwise, will include an explanation in reasonable detail of the reasons for their
award. Judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The Parties expressly waive any putative right they may otherwise have to seek an award arising out of any dispute hereunder of
punitive damages or any other damages limited or excluded by this Agreement. The arbitrator will have the authority to grant injunctive relief and other specific performance. The arbitrator will, in rendering its decision, apply the substantive law
of the State of North Carolina, without regard to its conflict of laws provisions. The decision and/or award rendered by the arbitrator will be final and non- appealable (except for an alleged act of corruption or fraud on the part of the
arbitrator). 

  

	23.3	Expenses. All expenses and fees of the arbitrators and expenses for hearing facilities and other expenses of the arbitration will be borne equally by the Parties unless the Parties agree otherwise or unless the
arbitrators in the award assess such expenses against one of the Parties or allocate such expenses other than equally between the Parties. Each of the Parties will bear its own counsel fees and the expenses of its witnesses except (i) to the
extent otherwise provided in this Agreement or by applicable law or (ii) to the extent the arbitrators in their discretion determine for any reason to allocate such fees and expenses among the Parties in a different manner. Any attorney or
retired judge who serves as an arbitrator will be compensated at a rate equal to his or her current regular hourly billing rate unless otherwise mutually agreed upon by the Parties and the arbitrator. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	23.4	Interlocutory Relief. Compliance with this Article 23 is a condition precedent to seeking relief in any court or tribunal in respect of a dispute, but nothing in this Article 23 will prevent a Party
from seeking interlocutory relief in the courts of appropriate jurisdiction provided in Article 22, pending the arbitrator’s determination of the merits of the controversy, if applicable to protect the Confidential Information, property or
other rights of that Party. 

  

	24.	Assignment and Delegation 

  

	24.1	Assignment. This Agreement between the Parties shall not be assigned in whole or in part by either Party without the prior written consent of the other, which consent shall not be unreasonably withheld or
delayed; provided, however, either Party may assign this Agreement in its entirety without the other Party’s consent, upon written notice to the other Party, as part of: (a) the sale of all or substantially all of the assets or the entire
business to which this Agreement relates, or (b) a merger, consolidation, reorganization or other combination with or into another person or entity, in each case, pursuant to which the surviving entity or assignee assumes in writing the
assigning or merging Party’s obligations hereunder. Any attempt to assign, or purported assignment of, this Agreement in contravention to this Section 24.1 shall be void ab initio and of no effect. This Agreement shall be binding
upon and inure to the benefit of the Parties hereto and their respective successors and permitted assigns. 

  

	24.2	Delegation. KBI Biopharma shall not delegate the performance of its obligations under this Agreement; however, performance of the Services hereunder may be delegated or subcontracted by KBI Biopharma with the
written consent of Client, which consent shall not be unreasonably withheld. In the event KBI Biopharma subcontracts its obligations hereunder, KBI Biopharma shall require the subcontractor to be bound by the terms of this Agreement, and KBI
Biopharma shall be liable for the act, omissions and breaches of this Agreement by such subcontractors such that any breach of this Agreement by such subcontractors shall be deemed a breach hereof by KBI Biopharma. 

 

	25.	Term and Termination 

  

	25.1	Term. The term of this Agreement (the “Term”) shall be from the Effective Date until the third anniversary thereof, unless extended or earlier terminated as provided herein. If the
Services have not been completed at the end of the initial term, the Term will thereafter be extended for successive one year periods until the Services have been completed. Additionally, the Agreement may be terminated sooner as provided in
Section 25.2 or 25.3, or the Term may be extended by written agreement of the Parties. 

  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

	25.2	Termination without Breach. Client may terminate this Agreement or a Proposal prior to completion of the Proposal by providing sixty (60) days written notice to KBI Biopharma, subject to the conditions of
this Section 25.2. Upon receipt of such notice of termination, KBI Biopharma will promptly scale down the affected portion of the Proposal and use reasonable commercial efforts to avoid (or minimize, where non-cancellable) additional expenses.

  

	25.3	Termination for Breach. In the event of a material breach of this Agreement by a Party that is not cured within thirty (30) days of written notice of such breach by the non- breaching Party, the
non-breaching Party may terminate this Agreement or a Proposal immediately upon written notice. Upon such termination, KBI Biopharma will promptly scale down the affected portion of the Proposal and use its reasonable commercial efforts to avoid (or
minimize, where non-cancellable) additional expenses. 

  

	25.4	Bankruptcy. This Agreement may be terminated upon written notice by a Party in the event: (i) the other Party voluntarily enters into bankruptcy proceedings; (ii) the other Party makes an assignment for
the benefit of creditors; (iii) a petition is filed against the other Party under a bankruptcy law, a corporate reorganization law, or any other law for relief of debtors or similar law analogous in purpose or effect, which petition is not
stayed or dismissed within thirty (30) days of filing thereof; or (iv) the other Party enters into liquidation or dissolution proceedings or a receiver is appointed with respect to any assets of the other Party, which appointment is not
vacated within one hundred and twenty (120) days. 

  

	25.5	Effects of Termination. Upon termination of this Agreement for any reason, each Party shall, as soon as practicable, but in any event within ten (10) business days of the effective date of termination,
return to the other all Confidential Information which it possesses that belongs to the other Party, except that each may retain a copy in its law department for record keeping purposes. Upon termination of this Agreement, KBI Biopharma will furnish
to Client a complete inventory of all work in progress and an inventory of all Product processed pursuant to the Proposal. Upon termination of this Agreement, neither Party shall use or exploit in any manner whatsoever any intellectual property
rights or Confidential Information of the other Party, excepted as may be specifically provided in this Agreement. With respect to the liquidated damages set forth in Section 25.2 and Section 25.3, the Parties acknowledge and agree that
(i) actual damages would be difficult or impracticable to ascertain, (ii) the amounts set forth in Section 25.2 or Section 25.3, as applicable, represent the Parties reasonable estimate of such damages, and (iii) the amounts
set forth in this Section 25.2 or Section 25.3, as applicable, are not unreasonable under the circumstances existing at the time this Agreement was entered. 

 
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information. 

	26.	Survival 

 Articles 4, 6, 10, 11, 13, 14, 15, 19, 20, 21, 22, 23, 26, and Sections 7.2.7, 7.4,
12.2.4, 17.2, 25.2, 25.3 and 25.5 hereof shall survive termination or expiration of this Agreement. Expiration or termination shall not extinguish the rights and remedies of either Party with respect to any ,antecedent breach of any of the
provisions of this Agreement or payments due or earned under this Agreement. 
  

	27.	Severability 

 In the event that any one or more of the provisions of this Agreement should be held for
any reason by any court or authority having final jurisdiction over this Agreement, or over any of the Parties to this Agreement, to be invalid, illegal, or unenforceable, such provision or provisions shall be reformed to approximate as nearly as
possible the intent of the Parties, and if not reformable, shall be divisible and deleted in such jurisdictions; elsewhere, this Agreement shall not be affected. 
  

	28.	Waiver and Remedies 

 The delay or waiver (or single or partial exercise) by either Party hereto of any
right, power, or privilege hereunder, or of any failure of the other Party to perform, or of any breach by the other Party, shall not be deemed a waiver of any other right, power, or privilege hereunder or of any other breach by or failure of such
other Party, whether of a similar nature or otherwise. Any such waiver must be made in writing. Except as may otherwise be specifically set forth in this Agreement, no remedy referred to in this Agreement is intended to be exclusive, but each shall
be cumulative and in addition to any other remedy referred to in this Agreement or otherwise available under law or equity. No Party shall have any right of set off with respect to amounts it has an obligation to pay hereunder. No provision of this
Agreement shall in any way inure to the benefit of any third person so as to constitute to any such person a third-party beneficiary of this Agreement or otherwise give rise to any cause of action in any person not a Party hereto. 

 

	29.	Counterparts 

 This Agreement, the Quality Agreement(s), the Proposal and any other attachment may be
executed in counterparts, each of which will be deemed an original but all of which together will constitute a single instrument. A facsimile or electronic transmission of the above referenced documents, or a counterpart, shall be legal and binding
on the Parties. 
  

	30.	Headings 

 All article and section titles or headings contained in this Agreement, the Quality Agreement
and the Proposal are for convenience only, will not be deemed a part hereof or thereof, and will not affect the meaning or interpretation of this Agreement. 

[Signature Page Follows.] 
  

 
 [***]Certain confidential information
contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect
to this information. 

 In Witness Whereof, the Parties by their authorized representatives execute this Agreement as of the Effective
Date. 
  

									
	KBI BIOPHARMA, INC.				AEGLEA DEVELOPMENT COMPANY, INC.
					
	By:		/s/ Andrew B. Cohen				By:		/s/ David G. Lowe
					
	Name:		Andrew B. Cohen				Name:		David G. Lowe
					
	Title:		VP & General Counsel				Title:		President and Chief Executive Officer
					
	Date:		12/24/2013				Date:		12/24/2013

  
  

[***]Certain confidential information contained in this document, marked by brackets, has been omitted and filed separately with the Securities and Exchange
Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. Confidential treatment has been requested with respect to this information.EX-10.11

 Exhibit 10.11 

Barton Oaks Plaza One 

Austin, Texas 
 OFFICE
LEASE 
 BETWEEN 

BARTON OAKS OFFICE CENTER, LLC 

(“LANDLORD”) 

AND 
 AEGLEA DEVELOPMENT
COMPANY, INC. 
 (“TENANT”) 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	 1.
	 	 Basic Lease Information
	  	 	1	  
	 2.
	 	 Lease Grant
	  	 	3	  
	 3.
	 	 Term; Adjustment of Commencement Date; Early Access
	  	 	3	  
	 4.
	 	 Rent
	  	 	4	  
	 5.
	 	 Tenant’s Use of Premises
	  	 	9	  
	 6.
	 	 Security Deposit
	  	 	10	  
	 7.
	 	 Services to be Furnished by Landlord
	  	 	11	  
	 8.
	 	 Use of Electrical Services by Tenant
	  	 	13	  
	 9.
	 	 Repairs and Alterations
	  	 	14	  
	 10.
	 	 Entry by Landlord
	  	 	16	  
	 11.
	 	 Assignment and Subletting
	  	 	16	  
	 12.
	 	 Liens
	  	 	18	  
	 13.
	 	 Indemnity
	  	 	19	  
	 14.
	 	 Insurance
	  	 	19	  
	 15.
	 	 Mutual Waiver of Subrogation
	  	 	20	  
	 16.
	 	 Casualty Damage
	  	 	21	  
	 17.
	 	 Condemnation
	  	 	22	  
	 18.
	 	 Events of Default
	  	 	22	  
	 19.
	 	 Remedies
	  	 	23	  
	 20.
	 	 Limitation of Liability
	  	 	25	  
	 21.
	 	 No Waiver
	  	 	26	  
	 22.
	 	 Tenant’s Right to Possession
	  	 	26	  
	 23.
	 	 Relocation
	  	 	26	  
	 24.
	 	 Holding Over
	  	 	27	  
	 25.
	 	 Subordination to Mortgages; Estoppel Certificate
	  	 	27	  
	 26.
	 	 Attorneys’ Fees
	  	 	27	  
	 27.
	 	 Notice
	  	 	28	  
	 28.
	 	 Reserved Rights
	  	 	28	  
	 29.
	 	 Surrender of Premises
	  	 	28	  
	 30.
	 	 Hazardous Materials
	  	 	29	  
	 31.
	 	 Miscellaneous
	  	 	30	  

 EXHIBITS AND RIDERS: 
  

			
	 EXHIBIT A-1
	  	OUTLINE AND LOCATION OF PREMISES
	 EXHIBIT A-2
	  	LEGAL DESCRIPTION OF PROPERTY
	 EXHIBIT B
	  	RULES AND REGULA TIONS
	 EXHIBIT C
	  	COMMENCEMENT LETTER
	 EXHIBIT D
	  	WORK LETTER
	 EXHIBIT E
	  	PARKING AGREEMENT

  
 i 

 OFFICE LEASE 

This Office Lease (this “Lease”) is entered into by and between BARTON OAKS OFFICE CENTER, LLC, a
Delaware limited liability company (“Landlord”), and AEGLEA DEVELOPMENT COMPANY, INC., a Delaware corporation (“Tenant”), and shall be effective as of the date set forth below Landlord’s signature
(the “Effective Date”). 
 1. Basic Lease Information. The key business terms used in
this Lease are defined as follows: 
 A. “Building”: The building commonly known
as Barton Oaks Plaza, Building One, and located at 901 MoPac Expressway South, Austin, Texas. 
 B. “Rentable
Square Footage of the Building” is agreed and stipulated to be 99,404 square feet. 
 C.
“Premises”: The area shown on Exhibit A-1to this Lease. The Premises are located on floor two (2) of the Building and known as suite number 250. The “Rentable Square Footage of the
Premises” is deemed to be 5,771 square feet. If the Premises include, now or hereafter, one or more floors in their entirety, all corridors and restroom facilities located on such full floor(s) shall be considered part of the Premises.
Landlord and Tenant stipulate and agree that the Rentable Square Footage of the Building and the Rentable Square Footage of the Premises are correct and shall not be remeasured. 

D. “BaseRent”: 
  

									
	 Period

(in Lease Months)
	 	Annnal Rate
Per Square Foot	 	 	Monthly
Base Rent	 
	1 to 12	 	$	23.50	  	 	$	11,301.54	  
	13 to 24	 	$	24.21	  	 	$	11,642.99	  
	25 to 36	 	$	24.93	  	 	$	11,989.25	  

 As used herein, a “LeaseMonth” means a period of time commencing on the same numeric day as the Commencement Date
and ending on (but not including) the day in the next calendar month that is the same numeric date as the Commencement Date; provided, however, that if the Commencement Date does not occur on the first day of a calendar month, then the first (!st)
Lease Month shall be extended to end on the last day of the first (1st) full calendar month following the Commencement Date, Tenant shall pay Base Rent during the resulting partial calendar month at the same rate payable for the first (!st)
Lease Month (prorated based on the number of days in such partial calendar month), and the succeeding Lease Months shall commence on the first day of each calendar month thereafter. 

E. “Tenant’s Pro Rata Share”: The percentage equal to the Rentable Square
Footage of the Premises divided by the Rentable Square Footage of the Building. 
 F. “Term”:
The period of approximately thirty-six (36) months starting on the Commencement Date, subject to the provisions of Article 3. 

G. “Estimated Commencement Date”: February 1, 2015, subject to adjustment, if
any, as provided in Section 3.A and the Work Letter. 
 H.
“Guarantor(s)”: Any person or entity who agrees to guarantee the obligations of the Tenant under this Lease. As of the date of this Lease, there are no Guarantors. 

  
 1 

 I. “Business Day(s)”: Monday through
Friday of each week, exclusive of New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day, and Christmas Day (“Holidays”). Landlord may designate additional Holidays, provided that the additional Holidays are
commonly recognized by other office buildings in the area where the Building is located. 
 J.
“Law(s)”: All applicable statutes, codes, ordinances, orders, rules and regulations of any municipal or governmental entity, now or hereafter adopted, including the Americans with Disabilities Act and any
other law pertaining to disabilities and architectural barriers (collectively, “ADA”), and all laws pertaining to the environment, including the Comprehensive Environmental Response, Compensation and Liability Act, as
amended, 42 U.S.C. §9601 et seq. (“CERCLA”), and all restrictive covenants existing of record and all rules and requirements of any existing association or improvement district affecting the Property. 

K. “Normal Business Hours”: 8:00 A.M. to 6:00 P.M. on Business Days and 8:00 A.M.
to 1:00 P.M. on Saturdays, exclusive of Holidays. 
 L. “Notice
Addresses”: 
 Tenant: On or after the Commencement Date, all notices shall be sent to Tenant at the Premises. Prior to the
Commencement Date, notices shall be sent to Tenant at the following address: 
  

			
	 Aeglea Development Company, Inc.

815 Brazos, Suite 101A

Austin, Texas 78701-2562

Attn: David Lowe

Phone #:

Fax #:
		
		
	 Landlord:
		
		
	 Barton Oaks Office Center, LLC

c/o MIG Real Estate

660 Newport Center Drive

Suite 1300

Newport Beach, CA 92660

Attn: Director of Asset Management
		 Landlord’s address for payment of Rent:

Barton Oaks Office Center, LLC
 c/o PM Realty Group, LP

18201 Von Karman Avenue, Suite 500
 Irvine, CA 92612

Attention: Kari Blevins

		
	 With a copy to:
		
		
	 Barton Oaks Office Center, LLC

c/o TIG Real Estate Services, Inc.

901 South Mopac Expressway

Barton Oaks Plaza IV, Suite 285

Austin, TX 78746
		

 M. “Security Deposit”: $53,756.86 (see
Article 6 of this Lease). 

  
 2 

 N. “Other Defined Terms”: In addition
to the terms defined above, an index of some of the other defined terms used in the text of this Lease is set forth below, with a cross-reference to the paragraph in this Lease in which the definition of such term can be found: 

 

					
	 Affiliate
		11.F		
	 Alterations
		9.C(1)		
	 Anti-Terrorism Laws
		31.O		
	 Approved Construction Documents
		EXHIBIT D		
	 Bankruptcy law
		11.E		
	 Cable
		9.A		
	 Change Order
		EXHIBIT D		
	 Claims
		13		
	 Code
		31.N		
	 Commencement Date
		3.A		
	 Common Areas
		2		
	 Completion Estimate
		16.B		
	 Construction Documents
		EXHIBIT D		
	 Cost Overruns
		EXHIBIT D		
	 Costs of Reletting
		19.B(2)		
	 ERISA
		31.N		
	 Expiration Date
		3.A		
	 Force Majeure
		31.C		
	 Hazardous Materials
		30		
	 Hourly HVAC Charge
		7.A(2)		
	 Interruption Notice
		7.B		
	 Landlord Parties
		13		
	 Landlord Termination Date
		11.B		
	 Landlord Work
		3.A		
	 Landlord’s Rental Damages
		19.B(2)		
	 Leasehold Improvements
		29		
	 Minor Alteration
		9.C(1)		
	 Monetary Default
		18.A		

					
			 Mortgage
		25
			 Mortgagee
		25
			 Notice
		27
			 OE Payment
		4.B
			 Operating Expenses
		4.D
			 Parking Facilities
		EXHIBIT E
			 Permitted Transfer
		11.F
			 Permitted Use
		5.A
			 Prohibited Persons
		31.O
			 Property
		2
			 Provider
		7.C
			 Real Estate Taxes
		4.D(5)
			 Relocation Notice
		23
			 Rent
		4.A
			 Service Failure
		7.B
			 Sign
		EXHIBIT B
			 Substantially Complete
		EXHIBIT D
			 Substitute Premises
		23
			 Taking
		17
			 Tenant Delay
		EXHIBIT D
			 Tenant Parties
		13
			 Tenant’s Information
		EXHIBIT D
			 Tenant’s Property
		14.A(2)
			 Tenant’s Removable Property
		29
			 Time Sensitive Default
		18.B
			 Transfer
		11.A
			 USA Patriot Act
		31.O
			 Work Letter
		3.A

 
 

  
 2. Lease
Grant. Landlord leases the Premises to Tenant and Tenant leases the Premises from Landlord, together with the right in common with others to use any portions of the Property (defined below) that are designated by Landlord for
the common use of tenants and others, such as sidewalks, common corridors, elevators, vending areas, lobby areas and, with respect to multi-tenant floors, restrooms and elevator foyers (the “Common Areas”). As used herein,
“Property” means the Building and the parcel(s) of land on which it is located as more fully described on Exhibit A-2, together with all other buildings and improvements located
thereon; and the Building garage(s) and other improvements serving the Building, if any, and the parcel(s) of land on which they are located. 

3. Term; Adjustment of Commencement Date; Early Access. 

A. Term. This Lease shall govern the relationship between Landlord and Tenant with respect to the
Premises from the Effective Date through the last day of the Term specified in Section 1.F (the “Expiration Date”), unless terminated early in accordance with this Lease. The Term of
this Lease (as specified in Section 1.F) shall commence on the “Commencement Date”, which shall be the earliest of (1) the date on which Landlord delivers the Premises to Tenant
with the Landlord Work (defined below) Substantially Complete, as determined pursuant to the Work Letter (defined below), or (2) the date on which the Landlord Work would have been Substantially Complete but for Tenant Delay, as such term is
defined in the Work Letter, or (3) the date on which Tenant first occupies the Premises for the conduct of its business therein. If Landlord is delayed in delivering possession of the Premises or any other space due to any reason, including
Landlord’s failure to Substantially Complete the Landlord Work by the Estimated Commencement Date, or for any other reason, such delay shall not be a default by  

  
 3 

 
Landlord, render this Lease void or voidable, or otherwise render Landlord liable for damages. Promptly after the determination of the Commencement Date and the Expiration Date, Landlord
shall prepare and deliver to Tenant a commencement letter agreement substantially in the form attached as Exhibit C. If such commencement letter is not executed by Tenant within 30 days after delivery of
same by Landlord, then Tenant shall be deemed to have agreed with the matters set forth therein. Notwithstanding any other provision of this Lease to the contrary, if the Expiration Date would otherwise occur on a date other than the last day of a
calendar month, then the Term shall be automatically extended to include the last day of such calendar month, which shall become the Expiration Date. “Landlord Work” means the work that Landlord is obligated to perform in the Premises
pursuant to a separate work letter agreement (the “Work Letter”) attached as Exhibit D. 

B. Acceptance of Premises. The Premises are accepted by Tenant in “as is” condition and configuration subject to
(1) any Landlord obligation to perform Landlord Work, (2) any defects in the Landlord Work of which Tenant notifies Landlord within 180 days after the Commencement Date, and (3) Landlord’s repair and maintenance obligations
hereunder. EXCEPT AS OTHERWISE EXPRESSLY SET FORTH HEREIN, NO WARRANTIES, EXPRESS OR IMPLIED, ARE MADE REGARDING THE CONDITION OR SUITABILITY OF THE PREMISES ON THE COMMENCEMENT DATE. FURTHER, TO THE EXTENT PERMITTED BY LAW, TENANT WAIVES ANY
IMPLIED WARRANTY OF SUITABILITY OR OTHER IMPLIED WARRANTIES THAT LANDLORD WILL MAINTAIN OR REPAIR THE PREMISES OR ITS APPURTENANCES EXCEPT AS MAY BE CLEARLY AND EXPRESSLY PROVIDED IN THIS LEASE. The foregoing shall not reduce or otherwise affect
Landlord’s express repair and maintenance obligations under this Lease. 
 C. Early Access. Prior to the date the
Landlord Work is Substantially Complete, Tenant’s access to the Premises shall be permitted only with the prior written consent of Landlord. Early access to the Premises shall be subject to all of the terms and conditions of this Lease;
provided that Tenant shall not be required to pay Rent (defined in Section 4.A) during such early access period. Notwithstanding the foregoing, provided such access does not unreasonably interfere with the Landlord Work, Landlord shall
permit Tenant to have early access to the Premises approximately two (2) weeks prior to the Commencement Date for the sole purpose of installing furniture, equipment or other personal property, and except for the cost of services requested by
Tenant (e.g., freight elevator usage), Tenant shall not be required to pay Base Rent and the OE Payment (defined in Section 4.B) for any days of such early access. Notwithstanding the foregoing, if Tenant begins to conduct business in
the Premises during such early access period, the date Tenant begins conducting business shall thereupon be deemed the Commencement Date, and Base Rent and the OE Payment shall thereupon commence. 

4. Rent. 
 A.
Payments. As consideration for this Lease, commencing on the Commencement Date, Tenant shall pay Landlord, without any demand, setoff or deduction (except as otherwise expressly set forth herein), the total amount of Base Rent,
Tenant’s Pro Rata Share of the Operating Expenses (defined in Section 4.D) and all other sums payable by Tenant under this Lease (all of which are sometimes collectively referred to as “Rent”). Tenant shall
pay and be liable for all rental, sales and use taxes (but excluding income taxes), if any, imposed upon or measured by Rent under applicable Law. The monthly Base Rent and the OE Payment (defined in Section 4.B) shall be due and payable
in advance on the first day of each calendar month without notice or demand, provided that the installment of Base Rent and the OE Payment for the first (1st) Lease Month of the Term shall be payable upon the execution of this Lease by Tenant.
All other items of Rent shall be due and payable by Tenant on or before 30 days after billing by Landlord. All payments of Rent shall be by good and sufficient check or by other means (such as automatic debit or electronic transfer) acceptable to
Landlord. If the Term commences on a day other 

  
 4 

 
than the first day of a calendar month, the monthly Base Rent and the OE Payment for the month shall be prorated on a daily basis based on a 365 day calendar year. Landlord’s acceptance of
less than the correct amount of Rent shall be considered a payment on account of the earliest Rent due. No endorsement or statement on a check or letter accompanying a check or payment shall be considered an accord and satisfaction, and either party
may accept such check or payment without such acceptance being considered a waiver of any rights such party may have under this Lease or applicable Law. Tenant’s covenant to pay Rent is independent of every other covenant in this Lease. 

B. Payment of Operating Expenses. Tenant shall pay Tenant’s Pro Rata Share of the Operating Expenses (the “OE
Payment”) for each calendar year during the Term. On or about January 1 of each calendar year, Landlord shall provide Tenant with a good faith estimate of the OE Payment for such calendar year during the Term. On or before the
first day of each month, Tenant shall pay to Landlord a monthly installment equal to one-twelfth of Landlord’s estimate of the OE Payment for such calendar year. If Landlord determines that its good faith estimate of the OE Payment was
incorrect, Landlord may provide Tenant with a revised good faith estimate. After its receipt of the revised good faith estimate, Tenant’s monthly payments shall be based upon the revised good faith estimate. If Landlord does not provide Tenant
with a good faith estimate of the OE Payment by January 1 of a calendar year, Tenant shall continue to pay monthly installments based on the most recent good faith estimate(s) until Landlord provides Tenant with the new good faith estimate.
Upon delivery of the new estimate, an adjustment shall be made for any month for which Tenant paid monthly installments based on the same year’s prior incorrect good faith estimate(s). Tenant shall pay Landlord the amount of any underpayment
within 30 days after receipt of the new estimate. Any overpayment shall be credited against the next sums due and owing by Tenant or, if no further Rent is due, refunded directly to Tenant within 30 days of determination. The obligation of Tenant to
pay the OE Payment as provided herein shall survive the expiration or earlier termination of this Lease. 
 C. Reconciliation of
Operating Expenses. Within 120 days after the end of each calendar year or as soon thereafter as is reasonably practicable, Landlord shall furnish Tenant with a statement of the actual Operating Expenses and the OE Payment for such calendar
year. If the estimated OE Payment actually paid by Tenant for such calendar year is more than the actual OE Payment for such calendar year, Landlord shall apply any overpayment by Tenant against Rent due or next becoming due; provided, if the Term
expires before the determination of the overpayment, Landlord shall, within 30 days of determination, refund any overpayment to Tenant after first deducting the amount of Rent due. If the estimated OE Payment actually paid by Tenant for the prior
calendar year is less than the actual OE Payment for such year, Tenant shall pay Landlord, within 30 days after its receipt of the statement of Operating Expenses and the OE Payment, any underpayment for the prior calendar year. 

D. Operating Expenses Defined. “Operating Expenses” means all costs and expenses incurred or accrued in
each calendar year in connection with the ownership, operation, maintenance, management, repair and protection of the Property, including Landlord’s personal property used in connection with the Property and including without limitation all
costs and expenditures relating to the following: 
 (1) Operation, maintenance, repair and replacements of any part of the Property
(subject to paragraph (9) below), including the mechanical, electrical, plumbing, HVAC, vertical transportation, fire prevention and warning and access control systems; materials and supplies (such as light bulbs and ballasts); equipment and
tools; floor, wall and window coverings; personal property; required or beneficial easements; and related service agreements and rental expenses. 

(2) Administrative and management fees and expenses, including fees and expenses for accounting, auditing, legal, information and other
professional services (except for such fees and 

  
 5 

 
expenses incurred in connection with negotiating or enforcing any leases); management office(s); and wages, salaries, benefits, reimbursable expenses and taxes (or allocations thereof) for full
and part time personnel involved in operation, maintenance and management; provided, however, in no event shall management fees exceed five percent (5%) if the gross revenue of the Property for such year. 

(3) Janitorial service; window cleaning; waste disposal; and landscaping, including all applicable tools and supplies. 

(4) Property, liability and other insurance coverages carried by Landlord, including deductibles and risk retention programs and a
proportionate allocation of the cost of blanket insurance policies maintained by Landlord and/or its Affiliates (defined below). 
 (5)
“Real Estate Taxes”, which shall mean (i) all real estate taxes and assessments on the Property, the Building or the Premises, and taxes and assessments levied in substitution or supplementation in whole or in part of
such taxes, (ii) all personal property taxes for the Building’s personal property which are owned by Landlord and used in connection with the operation, maintenance and repair of the Property, including license expenses, (iii) all
franchise taxes and all sales, use and other taxes (excluding state and/or federal income tax) now or hereafter imposed by any governmental authority upon rent received by Landlord or revenue from the Property (provided that for the purposes of
calculating the taxes under this part (iii), the Property shall be treated as the only property used for the computation of such taxes), and (iv) all other taxes, fees or assessments now or hereafter levied by any governmental authority on the
Property, the Building or its contents or on the operation and use thereof (except as relate to specific tenants). Estimates of Real Estate Taxes for any calendar year during the Lease Term shall be determined based on Landlord’s good faith
estimate of the Real Estate Taxes. Real Estate Taxes hereunder are those accrued with respect to such calendar year, as opposed to the Real Estate Taxes paid or payable for such calendar year. Notwithstanding anything to the contrary contained
herein, Real Estate Taxes shall not include Landlord’s estate, excise, income, excess profits, inheritance, succession, grantor’s, recordation, transfer, or other taxes imposed on or measured by the net income of Landlord from the
operation of the Property (except to the extent provided in subsection (iii) above), and shall not include any interest or penalties for late payment of taxes. 

(6) Compliance with Laws, including license, permit and inspection fees (but not in duplication of capital expenditures amortized as provided
in Section 4.D(9)), but only to the extent that such compliance related to Laws that are amended, become effective, or are interpreted or enforced differently, after the Commencement Date; and all expenses and fees, including
attorneys’ fees and court or other venue of dispute resolution costs, incurred in negotiating or contesting Real Estate Taxes or the validity and/or applicability of any governmental enactments which may affect Operating Expenses; provided
Landlord shall credit against Operating Expenses any refunds received from such negotiations or contests to the extent originally included in Operating Expenses (less Landlord’s reasonable costs actually incurred). 

(7) Building safety services, to the extent provided or contracted for by Landlord. 

(8) Goods and services purchased from Landlord’s subsidiaries and Affiliates to the extent the cost of same is generally consistent with
rates charged by unaffiliated third parties for similar goods and services. 
 (9) Amortization of capital expenditures incurred:
(a) to conform with Laws but only to the extent that such compliance is related to Laws that are amended, become effective, or are interpreted or enforced differently, after the Commencement Date; (b) to provide or maintain Building
standards (other than Building standard tenant improvements); or (c) with the intention of promoting 

  
 6 

 
safety or reducing or controlling increases in Operating Expenses, such as lighting retrofit and installation of energy management systems. Capital expenditures shall be amortized on a
straight-line basis on a over the useful life of the capital item at an interest rate reasonably determined by Landlord. 
 (10) The cost of
all utilities for the Property, including without limitation water, sewer, power, fuel, heating, lighting, air conditioning and ventilation, as well as the cost of changing utility providers and the sales, use, excise and other taxes assessed by
governmental authorities on such utility services. 
 E. Exclusions from Operating Expenses. Operating Expenses exclude the
following expenditures: 
 (1) Leasing commissions, attorneys’ fees and other expenses related to leasing tenant space and constructing
improvements for the sole benefit of an individual tenant. 
 (2) Goods and services furnished to an individual tenant of the Building which
are above Building standard and which are separately reimbursable directly to Landlord in addition to the OE Payment. 
 (3) Repairs,
replacements and general maintenance paid by insurance proceeds (or which would have been paid by insurance proceeds had Landlord maintained the insurance required to be maintained by Landlord under this Lease), condemnation proceeds, another tenant
(except as a component of operating expenses), or a responsible third party. 
 (4) Except as provided in Section 4.D(9),
depreciation, amortization, interest payments on any encumbrances on the Property and the cost of capital improvements or additions. 
 (5)
Expenses for repairs or maintenance related to the Property which have been reimbursed to Landlord pursuant to warranties or service contracts. 

(6) Interest or principal payments on indebtedness secured by liens against the Property, or costs of refinancing such indebtedness, or any
ground lease payments. 
 (7) Costs of installing any specialty service, such as an observatory, broadcasting facility, luncheon club, or
athletic or recreational club. 
 (8) Expenses for repairs or maintenance related to the Property which have been reimbursed to Landlord
pursuant to warranties or service contracts. 
 (9) Costs of purchasing any art work (such as sculptures or paintings) used to decorate the
Building. 
 (10) Costs of correcting defects in the original construction or any renovation of the Building. 

(11) Compensation paid to clerks, attendants or other persons in commercial concessions operated by Landlord which customarily sell products
or services to the public, including tenants of the Building. 

  
 7 

 (12) Expenses incurred in leasing or procuring new tenants, including advertising and marketing
expenses and expenses for preparation of leases or renovating space for new tenants, rent allowances, lease takeover costs, payment of moving costs and similar costs and expenses. 

(13) Landlord’s general overhead and general administrative expenses except to the extent permitted in Section 4.D(2),
including any costs incurred related to maintaining Landlord’s existence as an entity. 
 (14) Overtime and other costs of performing
work which is required to be performed by Landlord at Landlord’s sole cost and expense. 
 (15) Salaries of officers and executives of
Landlord above the level of Property manager, except to the extent permitted in Section 4.D(2). 
 (16) Costs relating to disputes
between Landlord and a specific tenant of the Building. 
 (17) The cost of any work or service performed for any tenant (including Tenant)
at such tenant’s cost. 
 (18) Any fees paid to parties related to, or affiliated with, Landlord to the extent the cost of same is not
generally consistent with rates charged by unaffiliated third parties for similar goods and services. 
 (19) Political contributions,
charitable contributions, contributions to civic organizations, entertainment charges (except for entertainments made available to all of the Building tenants), and other similar expenses. 

(20) Payments for rented equipment, the cost of which would constitute a capital expenditure not permitted hereunder if the equipment were
purchased, except equipment which is used in providing janitorial services and which is not affixed to the Building or during repairs to the Building. 

(21) Any late fees or fines for non-compliance with Laws applicable to the Building or due to late payment of taxes, utility bills or other
such costs. 
 F. Proration of Operating Expenses; Adjustments. If Landlord incurs Operating Expenses for the Property
together with one or more other buildings or properties, whether pursuant to a reciprocal easement agreement, common area agreement or otherwise, the shared costs and expenses shall be equitably prorated and apportioned by Landlord between the
Property and the other buildings or properties. If the Building is not 100% occupied during any calendar year or partial calendar year or if Landlord is not supplying services to the entire Building at any time during a calendar year or partial
calendar year, Operating Expenses shall be determined as if the Building had been 100% occupied and Landlord had been supplying services to the entire Building during that calendar year. The extrapolation of Operating Expenses under this Section
shall be performed by Landlord by adjusting the cost of those components of Operating Expenses that are impacted by changes in the occupancy of the Building. 

G. Tenant’s Audit Right. Tenant may, within 120 days after receiving Landlord’s reconciliation statement of the
Operating Expenses, give Landlord written notice (“Review Notice”) that Tenant intends to review Landlord’s records of the Operating Expenses for the calendar year which is covered by the reconciliation statement. Within
a reasonable time after receipt of the Review Notice, Landlord shall make all pertinent records available for inspection that are reasonably necessary for Tenant to conduct its review. If Tenant retains an agent to review Landlord’s records,
the agent must be a 

  
 8 

 
licensed CPA or with a CPA firm and shall not be compensated on a contingency fee basis. Tenant shall be solely responsible for all costs, expenses and fees incurred for the audit. Within
45 days after the records are made available to Tenant, Tenant shall have the right to give Land lord written notice (an “Objection Notice”) stating in reasonable detail any objection to Landlord’s statement of Operating
Expenses for that year. If Tenant fails to give Landlord an Objection Notice within the 45 day period or fails to provide Landlord with a Review Notice within the 120 day period described above, Tenant shall he deemed to have approved
Landlord’s statement of Operating Expenses and shall be barred from raising any claims regarding the Operating Expenses for that year. If Landlord and Tenant determine that Operating Expenses for the calendar year are less than reported,
Landlord shall provide Tenant with a credit against the next installment(s) of Rent in the amount of the overpayment by Tenant or, if no further Rent is due, refund the overpayment directly to Tenant within 30 days after determination. Likewise, if
Landlord and Tenant determine that Operating Expenses for the calendar year are greater than reported, Tenant shall pay Landlord the amount of any underpayment within 30 days after such determination. The records obtained by Tenant and its agent
shall he treated as confidential and each shall execute Landlord’s confidentiality agreement for Landlord’s benefit prior to commencing the audit. This paragraph shall not be construed to limit, suspend, or abate Tenant’s obligation
to pay Rent when due, including the OE Payment. Notwithstanding the foregoing, Tenant shall not be entitled to conduct such an audit if Tenant is in default under this Lease beyond the expiration of any applicable notice and cure period.

 5. Tenant’s Use of Premises. 

A. Permitted Use. The Premises shall be used only for general office use (the “Permitted Use”) and for no
other use whatsoever. Tenant shall not use or permit the use of the Premises for any purpose which is illegal, creates obnoxious odors (including tobacco smoke), noises or vibrations, is dangerous to persons or property, could increase
Landlord’s insurance costs, or which, in Landlord’s reasonable opinion, unreasonably disturbs any other tenants of the Building or interferes with the operation or maintenance of the Property. The following uses are expressly prohibited in
the Premises: schools, government offices or agencies; personnel agencies; collection agencies; credit unions; operating of a data processing business, telemarketing or reservation centers; medical treatment and health care; radio, television or
other telecommunications broadcasting; restaurants and other retail; customer service offices of a public utility company; or any other purpose which would overburden any of the Building Systems, Common Areas or parking facilities (including any use
which would create a population density in the Premises which is in excess of the density which is standard for the Building) or otherwise interfere with the operation of the Property. Subject to the terms and conditions of this Lease, including
without limitation, the Building rules and regulations set forth on Exhibit B attached hereto, Tenant, its permitted assigns and subtenants, and their respective employees, licensees and guests, shall have access to the Building and the Premises at
all times, 24-hours per day, every day of the year. Landlord will provide Tenant with a reasonable amount of space (if necessary) in Building risers and on the second (2nd) floor of the Building for the installation of Cable for Tenant’s
use in the Premises. 
 B. Compliance with Laws. Tenant shall comply with all Laws regarding the operation of Tenant’s
business and the use, condition, configuration and occupancy of the Premises (including without limitation all Alterations installed by Tenant) and the use of the Common Areas. Without limiting the foregoing, Tenant shall, at its expense, be
responsible for ADA (and any applicable state accessibility standard) compliance in the Premises, including restrooms on any floor now or hereafter leased or occupied in its entirety by Tenant, its Affiliates or transferees. Landlord shall, as an
Operating Expense (to the extent permitted under Article 4 above), be responsible for ADA (and any applicable state accessibility standard) compliance for the core areas of the Building and the exterior areas of the Property (including
elevators, Common Areas, and service areas), the Property’s parking facilities and all points of access into the Property. Landlord shall not be responsible for determining whether Tenant is a public accommodation under ADA or whether the
Approved Construction Documents (as defined in Exhibit D) 

  
 9 

 
or any plans and specifications for any Alterations (hereinafter defined) comply with ADA requirements, including submission of the Approved Construction Documents or the plans and specifications
for any other Alterations for review by appropriate state agencies. Such determinations, if desired by Tenant, shall be the sole responsibility of Tenant. Tenant, within 20 days after receipt, shall provide Landlord with copies of any notices Tenant
receives regarding a violation or alleged or potential violation of any Laws. Notwithstanding anything to the contrary contained herein, Landlord, at its expense (subject to reimbursement pursuant to Article 4 above, if and to the extent
permitted thereby), shall comply with all applicable Laws to the extent the same apply directly to the structural elements of the Building, including the Premises except to the extent such compliance is necessitated as a result of Tenant’s
Alterations or specific use of the Premises (as opposed to general office use), the Building Systems, the Common Areas of the Property as a whole, and any other portions of the Building located outside of Premises, including, without limitation,
telecommunications rooms and mechanical and electrical rooms and closets. Tenant shall comply with the rules and regulations of the Building attached as Exhibit B and such other reasonable rules and regulations (or modifications
thereto) adopted by Landlord from time to time; provided that such modifications shall not materially reduce Tenant’s rights, or materially increase Tenant’s obligations, under this Lease or materially interfere with Tenant’s use of
the Premises for the Permitted Use. Such rules and regulations will be applied in an equitable manner as determined by Landlord and Landlord shall not discriminate against Tenant in enforcement of such rules and regulations. Tenant shall also cause
its agents, contractors, subcontractors, employees, customers, and subtenants to comply with all rules and regulations. Landlord shall not discriminate against Tenant in enforcement of the Building rules and regulations. In the event of any conflict
between any such rules and regulations (or modifications thereto) and this Lease, the latter shall control. 
 C. Tenant’s
Security Responsibilities. Tenant shall (I ) lock the doors to the Premises and take other reasonable steps to secure the Premises and the personal property of all Tenant Parties (defined in Article 13) and any of Tenant’s transferees,
contractors or licensees in the Common Areas and parking facilities of the Building and Property, from unlawful intrusion, theft, fire and other hazards; (2) keep and maintain in good working order all security and safety devices installed in
the Premises by or for the benefit of Tenant (such as locks, smoke detectors and burglar alarms); and (3) reasonably cooperate with Landlord and other tenants in the Building on Building safety matters. Tenant acknowledges that any security or
safety measures employed by Landlord are for the protection of Landlord’s own interests; that Landlord is not a guarantor of the security or safety of the Tenant Parties or their property; and that such security and safety matters are the
responsibility of Tenant and the local law enforcement authorities. 
 6. Security Deposit. Tenant will pay Landlord on the date this
Lease is executed by Tenant the Security Deposit set forth in Section 1.M as security for the performance of the terms hereof by Tenant. Tenant shall not be entitled to interest thereon and Landlord may commingle such Security Deposit
with any other funds of Landlord. The Security Deposit shall not be considered an advance payment of rental or a measure of Landlord’s damages in case of default by Tenant. If Tenant is in default with respect to any provision of this Lease
beyond any applicable cure period, Landlord may, but shall not be required to, from time to time, without prejudice to any other remedy, use, apply or retain all or any part of this Security Deposit for the payment of any Rent or any other sum in
default or for the payment of any other amount which Landlord may spend or become obligated to spend by reason of Tenant’s default or to compensate Landlord for any other loss or damage which Landlord may suffer by reason of Tenant’s
default, including, without limitation, costs and attorneys’ fees incurred by Land lord to recover possession of the Premises. After any such application of any portion of the Security Deposit, Tenant shall pay to Landlord, immediately upon
demand, the amount so applied so as to restore the Security Deposit to its original amount. The Security Deposit, less any amounts retained by Landlord pursuant to this Article 6, shall be returned to Tenant within thirty (30) days after the
Expiration Date and otherwise in accordance with all applicable Laws. Tenant agrees that it will not assign or encumber or attempt to assign or encumber the monies deposited herein as the Security Deposit and that Landlord and its 

  
 10 

 
successors and assigns shall not be bound by any such actual or attempted assignment or encumbrance. Regardless of any assignment of this Lease by Tenant, Landlord may return the Security Deposit
to the original Tenant, in the absence of evidence satisfactory to Landlord of an assignment of the right to receive the Security Deposit or any part of the balance thereof. Notwithstanding the foregoing, provided that Tenant is not in default under
this Lease beyond any applicable cure period as of the effective date of any reduction in the Security Deposit, the Security Deposit shall be reduced to the following amounts: (i) $35,837.91 effective as of the last day of Lease Month 12, and
(ii) $17,918.95 effective as of the last day of Lease Month 24. If Tenant is in default under this Lease beyond any applicable cure period as of the effective date of any such reduction (or on the date Landlord would otherwise return the amount
of the reduction as provided above), then the Security Deposit shall remain in place without reduction. Landlord shall return any excess Security Deposit held by Landlord pursuant to the foregoing provisions of this Article 6 within thirty
(30) days after the effective date of any reduction. If Landlord transfers its interest in the Premises, Landlord shall assign the Security Deposit to the transferee. Landlord’s obligation to return the Security Deposit in accordance with
this Article 6 shall survive the expiration or earlier termination of this Lease. 
 7. Services to be Furnished by Landlord. 

A. Standard Services. Subject to the provisions of this Lease, Landlord agrees to furnish (or cause a third party provider to
furnish) the following services to Tenant during the Term: 
 (1) Water service for use in the lavatories on each floor on which the
Premises are located, and for use in the Premises, including any kitchenettes located therein (provided that Tenant shall be responsible for any improvements necessary to bring the water to the Premises). 

(2) Heat and air conditioning in season during Normal Business Hours, at such temperatures and in such amounts as required by governmental
authority or as Landlord determines are standard for the Building and which are comparable with that provided in other office buildings comparable to the Building in the southwest Austin submarket. Tenant, upon notice given no later than 3:00 p.m.
on the Business Day preceding the day for which HVAC service is requested, and subject to the capacity of the Building Systems, may request HVAC service during hours other than Normal Business Hours. Tenant shall pay Landlord for such additional
service at a rate equal to $35.00 per operating hour per floor (the “Hourly HVAC Charge”), with a two hour minimum charge. Landlord shall have the right, upon 30 days prior written notice to Tenant, to adjust the Hourly HVAC
Charge from time to time, based upon increases in HVAC costs, which costs include utilities, taxes, surcharges, labor, equipment, maintenance and repair. 

(3) Maintenance and repair of the Property as described in Section 9.B. 

(4) Janitorial service five days per week (excluding Holidays) which are comparable with that provided in other office buildings comparable to
the Building in the southwest Austin submarket. If Tenant’s use of the Premises, floor covering or other improvements require special services in excess of the standard services for the Building, Tenant shall pay the additional cost
attributable to the special services. 
 (5) Elevator service, subject to proper authorization and Landlord’s policies and procedures
for use of the elevator(s) in the Building. 
 (6) Electricity to the Premises for general office use, in accordance with and subject to the
terms and conditions in Article 8. 

  
 11 

 Landlord agrees that the above described services and the maintenance of the Building and its components,
including, without limitation, the Common Areas, shall be not less than the services and maintenance standards provided to other comparable buildings in the southwest Austin submarket, taking into account, the age and size of such buildings. 

B. Service Interruptions. For purposes of this Lease, a “Service Failure” shall mean any interruption,
suspension or termination of services being provided to Tenant by Landlord or by third-party providers, whether engaged by Tenant or pursuant to arrangements by such providers with Landlord, which are due to (1) the application of Laws;
(2) the failure, interruption or malfunctioning of any electrical or mechanical equipment, utility or other service to the Building or Property; (3) the performance of repairs, maintenance, improvements or alterations; or (4) the
occurrence of any other event or cause whether or not within the reasonable control of Landlord. No Service Failure shall render Landlord liable to Tenant, constitute a constructive eviction of Tenant, give rise to an abatement of Rent, or relieve
Tenant from the obligation to fulfill any covenant or agreement. In no event shall Landlord be liable to Tenant for any loss or damage, including the theft of Tenant’s Property (defined in Article 14), arising out of or in connection
with any Service Failure or the failure of any Building safety services, personnel or equipment. Notwithstanding the foregoing, if: (i) Landlord ceases to furnish any service described in Section 7.A(1), (2),
(5) or (6) in the Premises and Common Areas necessary for use of the Premises for a period in excess of 5 consecutive Business Days after Tenant notifies Landlord of such cessation (the ‘‘Interruption
Notice”; (ii) such cessation does not arise as a result of an act or omission of Tenant; (iii) such cessation is not caused by a fire or other casualty (in which case Article 16 shall control); (iv) the restoration
of such service is reasonably within the control of Landlord; and (v) as a result of such cessation, the Premises or a material portion thereof, is rendered untenantable and Tenant in fact ceases to use the Premises, or material portion
thereof, then Tenant, as its sole remedy, shall be entitled to receive an abatement of Base Rent payable hereunder during the period beginning on the 6th consecutive Business Day of such cessation and ending on the day when the service in question
has been restored. In the event the entire Premises has not been rendered untenantable by the cessation in service, the amount of abatement that Tenant is entitled to receive shall be prorated based upon the percentage of the Premises so rendered
untenantable and not used by Tenant. 
 C. Third Party Services. If Tenant desires any service which Landlord has not
specifically agreed to provide in this Lease, such as private security systems or telecommunications services serving the Premises, Tenant shall procure such service directly from a reputable third party service provider
(“Provider”) for Tenant’s own account. Tenant shall require each Provider to comply with the Building’s rules and regulations, all Laws, and Landlord’s reasonable policies and practices for the Building. Tenant
acknowledges Landlord’s current policy that requires all Providers utilizing any area of the Property outside the Premises to be approved by Landlord and to enter into a written agreement reasonably acceptable to Landlord prior to gaining
access to, or making any installations in or through, such area. Accordingly, Tenant shall give Landlord written notice sufficient for such purposes. Without limiting the generality of the foregoing, in the event that Tenant wishes at any time to
utilize the services of a telephone or telecommunications Provider whose equipment is not then servicing the Building, no such Provider shall be permitted to install its lines or other equipment within the Building without first securing the prior
written approval of the Landlord, which approval shall not be unreasonably withheld, conditioned, or delayed, and which approval shall include, without limitation, approval of the plans and specifications for the installation of the lines and/or
other equipment within the Building. Landlord’s approval shall not be deemed any kind of warranty or representation by Landlord, including, without limitation, any warranty or representation as to the suitability, competence, or financial
strength of the Provider. Without limitation of the foregoing standard, unless all of the following conditions are satisfied to Landlord’s satisfaction, it shall be reasonable for Landlord to refuse to give its approval: (i) Landlord shall
incur no expense whatsoever with respect to any aspect of the Provider’s provision of its services, including without limitation, the costs of installation, materials and services; (ii) prior to commencement

  
 12 

 
of any work in or about the Building by the Provider, the Provider shall supply Landlord with such written indemnities, insurance, financial statements, and such other items as Landlord
reasonably determines to be necessary to protect its financial interests and the interests of the Building relating to the proposed activities of the Provider; (iii) the Provider agrees to abide by such rules and regulations, building and other
codes, job site rules and such other requirements as are reasonably determined by Landlord to be necessary to protect the interests of the Building, the tenants in the Building and Landlord, in the same or similar manner as Landlord has the right to
protect itself and the Building with respect to repairs and Alterations as described in Article 9 of this Lease; (iv) Landlord determines that there is sufficient space in the Building for the placement of all of the Provider’s
equipment and materials; (v) the Provider agrees to abide by Landlord’s requirements, if any, that the Provider use existing Building conduits and pipes or use Building contractors (or other contractors approved by Landlord);
(vi) Landlord receives from the Provider such compensation as is determined by Landlord to compensate it for space used in the Building for the storage and maintenance of the Provider’s equipment, for the fair market value of a
Provider’s access to the Building, and the costs which may reasonably be expected to be incurred by Landlord; (vii) the Provider agrees to deliver to Landlord detailed “as built” plans immediately after the installation of the
Provider’s equipment is complete; and (viii) all of the foregoing matters are documented in a written license agreement between Landlord and the Provider, the form and content of which are reasonably satisfactory to Landlord. 

8. Use of Electrical Services by Tenant. 

A. Landlord’s Electrical Service. Subject to the terms of this Lease, Landlord shall furnish Building standard electrical
service to the Premises sufficient to operate customary lighting, office machines and other equipment of similar electrical consumption. For purposes hereof, Building standard electrical shall mean 4.0 watts of low voltage power on a connected load
basis per rentable square foot in the Premises. Landlord may, at any time and from time to time, calculate Tenant’s actual electrical consumption in the Premises by a survey conducted by a reputable consultant selected by Landlord. The cost of
any electrical consumption in excess of that which Landlord determines is standard for the Building shall be paid by Tenant in accordance with Section 8.D. The furnishing of electrical services to the Premises shall be subject to the
rules, regulations and practices of the supplier of such electricity and of any municipal or other governmental authority regulating the business of providing electrical utility service. Landlord shall not be liable or responsible to Tenant for any
loss, damage or expense which Tenant may sustain or incur if either the quantity or character of the electrical service is changed or is no longer available or no longer suitable for Tenant’s requirements. 

B. Selection of Electrical Service Provider. Landlord shall have and retain the sole right to select the provider of electrical
services to the Building and/or the Property. To the fullest extent permitted by Law, Landlord shall have the continuing right to change such utility provider. All charges and expenses incurred by Landlord due to any such changes in electrical
services, including maintenance, repairs, installation and related costs, shall be included in the electrical services costs referenced in Section 4.D(10), unless paid directly by Tenant. 

C. Submetering. If Tenant’s consumption of electrical services is in excess of Building standard use levels, Landlord shall
have the continuing right, upon 30 days written notice, to install a submeter for the Premises at Tenant’s expense. If submetering is installed for the Premises, Landlord may charge for Tenant’s actual electrical consumption monthly in
arrears for the kilowatt hours used, a rate per kilowatt hour equal to that charged to Landlord by the provider of electrical service to the Building during the same period of time (plus, to the fullest extent permitted by applicable Laws, an
administrative fee equal to 10% of such charge), except as to electricity directly purchased by Tenant from third party providers after obtaining Landlord’s consent to the same. In the event Landlord is unable to determine the exact kilowatt
hourly charge during the period of time, Landlord shall use the average 

  
 13 

 
kilowatt hourly charge to the Building for the first billing cycle ending after the period of time in question. Even if the Premises are submetered, Tenant shall remain obligated to pay
Tenant’s Pro Rata Share of the cost of electrical services as provided in Section 4.B, except that Tenant shall be entitled to a credit against electrical services costs equal to that portion of the amounts actually paid by Tenant
separately and directly to Landlord which are attributable to building standard electrical services submetered to the Premises. 
 D.
Excess Electrical Service. Tenant’s use of electrical service shall not exceed Building standard levels in voltage, rated capacity, use beyond Normal Business Hours or overall load. If Tenant requests permission to consume excess
electrical service, Landlord may refuse to consent or may condition consent upon conditions that Landlord reasonably elects (including the installation of utility service upgrades, meters, submeters, air handlers or cooling units). The costs of any
approved additional consumption (to the extent permitted by Law), installation and maintenance shall be paid by Tenant. 
 9. Repairs and
Alterations. 
 A. Tenant’s Repair Obligations. Tenant shall keep the Premises in good condition and repair,
ordinary wear and tear excepted. Tenant’s repair obligations include, without limitation, repairs to: (1) floor covering and/or raised flooring; (2) interior partitions; (3) doors; (4) the interior side of demising walls;
(5) electronic, phone and data cabling and related equipment (collectively, “Cable”) that is installed by or for the benefit of Tenant whether located in the Premises or in other portions of the Building;
(6) supplemental air conditioning units, private showers and kitchens, including hot water heaters, plumbing, dishwashers, ice machines and similar facilities serving Tenant exclusively; (7) phone rooms used exclusively by Tenant;
(8) Alterations (defined below) performed by contractors retained by Tenant, including related HVAC balancing; and (9) all of Tenant’s furnishings, trade fixtures, equipment and inventory. Prior to performing any such repair
obligation, Tenant shall give written notice to Landlord describing the necessary maintenance or repair. All work shall be performed at Tenant’s expense in accordance with the rules and procedures described in Section 9.C below. If
Tenant fails to make any repairs to the Premises for more than 15 days after notice from Landlord (although notice shall not be required if there is an emergency), Landlord may, in addition to any other remedy available to Landlord, make the
repairs, and Tenant shall pay to Landlord the reasonable cost of the repairs within 30 days after receipt of an invoice, together with an administrative charge in an amount equal to 10% of the cost of the repairs. In the event the item requiring
repair by Tenant hereunder is covered by a warranty, Tenant may utilize the contractor providing such warranty in order to perform such repairs, subject to Landlord’s prior written approval (such approval not to be unreasonably withheld,
conditioned or delayed). In such event and upon Tenant’s written request, Landlord shall assign to Tenant on a non-exclusive basis, any warranties provided to Landlord relating to any such item requiring repair, to extent assignable. 

B. Landlord’s Repair Obligations. Landlord shall keep and maintain in good repair and working order and make repairs to and
perform maintenance upon: (I) structural elements of the Building, including, without limitation, exterior and load-bearing walls, any other load-bearing elements, slab floors and foundations; (2) standard mechanical (including HVAC),
electrical, plumbing and fire/life safety systems serving the Building generally (including the Premises) (collectively, the “Building Systems”); (3) Common Areas; (4) the roof of the Building; (5) exterior
windows of the Building, including the Premises; and (6) elevators serving the Building. Landlord shall promptly make repairs (taking into account the nature and urgency of the repair) for which Landlord is responsible. If any of the foregoing
maintenance or repair is necessitated due to the acts or omissions of any Tenant Party (defined in Article 13), Tenant shall pay the costs of such repairs or maintenance to Landlord within 30 days after receipt of an invoice, together with an
administrative charge in an amount equal to 10% of the cost of the repairs. Landlord agrees to cause the repairs and replacements to be effected in compliance with all applicable Laws. 

  
 14 

 C. Alterations. 

(1) When Consent Is Required. Tenant shall not make alterations, additions or improvements to the Premises or install any Cable
in the Premises or other portions of the Building (collectively, “Alterations”) without first obtaining the written consent of Landlord in each instance (which consent shall not be unreasonably withheld, conditioned, or
delayed). However, Landlord’s consent shall not be required for any Alteration that satisfies all of the following criteria (a “Minor Alteration”): (a) is of a cosmetic nature such as painting, hanging pictures and
installing carpeting; (b) is not visible from outside the Premises or Building; (c) will not affect the systems or structure of the Building; (d) does not require work to be performed inside the walls or above the ceiling of the
Premises, (e) does not require a building permit, and (f) the cost of the Alteration does not exceed $10,000.00 in the aggregate. 

(2) Requirements For All Alterations, Including Minor Alterations. Prior to starting work on any Alteration, Tenant shall
furnish to Landlord for review and approval: plans and specifications (provided, however, Tenant shall not be required to furnish plans and specifications for Minor Alterations); names of proposed contractors (provided that Landlord may designate
specific contractors with respect to Building Systems); copies of contracts; necessary permits and approvals; evidence of contractors’ and subcontractors’ insurance; and Tenant’s security for performance of the Alteration. Changes to
the plans and specifications must also be submitted to Landlord for its approval. Some of the foregoing requirements may be waived by Landlord for the performance of specific Minor Alterations; provided that such waiver is obtained in writing prior
to the commencement of such Minor Alterations. Landlord’s waiver on one occasion shall not waive Landlord’s right to enforce such requirements on any other occasion. Alterations shall be constructed in a good and workmanlike manner using
materials of a quality that is at least equal to the quality designated by Landlord as the minimum standard for the Building. Landlord may designate reasonable rules, regulations and procedures for the performance of Alterations in the Building. All
Alterations shall be performed after Normal Business Hours, unless Landlord specifically consents to any work being performed during Normal Business Hours, which consent Landlord may withhold in its sole discretion. Tenant shall reimburse Landlord
within 30 days after receipt of an invoice for reasonable out-of-pocket sums paid by Landlord for third party examination of Tenant’s plans for Alterations. In addition, within 30 days after receipt of an invoice from Landlord, Tenant shall pay
to Landlord a fee equal to 5% of the total cost of such Alterations for Landlord’s oversight and coordination of any Alterations. No later than 30 days after completion of the Alterations, except for Minor Alterations, Tenant shall furnish
“as-built” plans, completion affidavits, full and final waivers of liens, receipts and bills covering all labor and materials. Tenant shall assure that the Alterations comply with all insurance requirements and Laws. Tenant shall be liable
for and shall pay, prior to their becoming delinquent, any and all taxes and assessments levied against, and any increases in Real Estate Taxes as a result of, any personal property or trade or other fixtures placed by Tenant in or about the
Premises and any Alterations constructed in the Premises by or on behalf of Tenant. In the event Landlord pays any such additional taxes or increases, Tenant will, within I 0 days after Landlord’s written demand, together with substantiating
proof of such additional taxes or increases, reimburse Landlord for the amount thereof. 
 (3) Landlord’s Liability For
Alterations. Landlord’s approval of an Alteration shall not be a representation by Landlord that the Alteration complies with applicable Laws or will be adequate for Tenant’s use. Tenant acknowledges that Landlord is not an
architect or engineer, and that the Alterations will be designed and/or constructed using independent architects, engineers and contractors. Accordingly, Landlord does not guarantee or warrant that the applicable construction documents will comply
with Laws or be free from errors or omissions, or that the Alterations will be free from defects, and Landlord will have no liability therefor. 

  
 15 

 10. Entry by Landlord. Subject to the terms of this Article 10, Landlord,
its agents, contractors and representatives may enter the Premises to inspect or show the Premises, to clean and make repairs, alterations or additions to the Premises, and to conduct or facilitate repairs, alterations or additions to any portion of
the Building, including other tenants’ premises. Except in emergencies or to provide janitorial and other Building services after Normal Business Hours, Landlord shall provide Tenant with at least twenty-four (24) hours’ prior notice
of entry into the Premises, which may be given orally. Landlord shall have the right to temporarily close all or a portion of the Premises to perform repairs, alterations and additions, if reasonably necessary for the protection and safety of Tenant
and its employees. Except in emergencies, Landlord will not close the Premises if the work can reasonably be completed on weekends and after Normal Business Hours; provided, however, that Landlord is not required to conduct work on weekends or after
Normal Business Hours if such work can be conducted without closing the Premises and such work does not materially and adversely interfere with Tenant’s use of the Premises. Entry by Landlord for any such purposes shall not constitute a
constructive eviction or entitle Tenant to an abatement or reduction of Rent. In connection with any such entry, Landlord shall use commercially reasonable efforts not to interfere with the operations and normal office routine of Tenant. Tenant may,
at its option, require that Landlord be accompanied by a representative of Tenant during any such entry (except in the event of emergency), provided that such representative of Tenant does not interfere with or delay Land lord in exercising its
rights or satisfying its obligations hereunder. 
 11. Assignment and Subletting. 

A. Landlord’s Consent Required. Subject to the remaining provisions of this Article 11, but notwithstanding anything
to the contrary contained elsewhere in this Lease, except for Permitted Transfers, Tenant shall not assign, transfer or encumber any interest in this Lease (either absolutely or collaterally) or sublease or allow any third party to use any portion
of the Premises (collectively or individually, a “Transfer”) without the prior written consent of Landlord. Landlord shall not unreasonably withhold, condition or delay its consent to a Transfer (other than a
collateral assignment). Without limitation, Tenant agrees that Landlord’s consent shall not be considered unreasonably withheld if: (1)the proposed transferee is a governmental organization, or Landlord is otherwise actively engaged in lease
negotiations with the proposed transferee for other premises in the Property; (2) any uncured event of default exists under this Lease; (3) any portion of the Building or Premises would likely become subject to additional or different Laws
as a consequence of the proposed Transfer; (4) the proposed transferee’s use of the Premises conflicts with the Permitted Use or any exclusive usage rights granted to any other tenant in the Building; (5) the use, nature, business,
activities or reputation in the business community of the proposed transferee (or its principals, employees or invitees) does not meet Landlord’s standards for Building tenants; (6) the proposed transferee is or has been involved in
litigation with Landlord or any of its Affiliates; (7) the character of the business to be conducted within the Premises by the proposed subtenant or assignee is likely to substantially increase the expenses or costs of providing Building
services, or the burden on parking, existing janitorial services or elevators in the Building, or (8) the proposed transferee’s financial condition does not meet the criteria Landlord uses to select Building tenants having similar
leasehold obligations. Any attempted Transfer in violation of this Article is voidable at Landlord’s option. 
 B. Consent
Parameters/Requirements. As part of Tenant’s request for, and as a condition to, Landlord’s consent to a Transfer, Tenant shall provide Landlord with financial statements for the proposed transferee, a complete copy (unexecuted) of
the proposed assignment or sublease and other contractual documents, and such other information as Landlord may reasonably request. Landlord shall then have the right (but not the obligation) to terminate this Lease as of the date the Transfer would
have  

  
 16 

 
been effective (“Landlord Termination Date”) with respect to the portion of the Premises which Tenant desires to Transfer; provided, however, Landlord shall not
have the right to terminate the portion of the Premises Tenant desires to sublease if such portion, together with all other portions of the Premises previously subleased, does not exceed 1,000 rentable square feet. In such event, Tenant shall vacate
such portion of the Premises by the Landlord Termination Date and upon Tenant’s vacating such portion of the Premises, the rent and other charges payable shall be proportionately reduced. Consent by Landlord to one or more Transfer(s) shall not
operate as a waiver of Landlord’s rights to approve any subsequent Transfers. In no event shall any Transfer (including without limitation any Permitted Transfer) release or relieve Tenant from any obligation under this Lease, nor shall the
acceptance of Rent from any assignee, subtenant or occupant constitute a waiver or release of Tenant from any of its obligations or liabilities under this Lease. Tenant shall pay Landlord a review fee of $1,000 for Landlord’s review of any
requested Transfer (including any Permitted Transfer), provided if Landlord’s actual reasonable costs and expenses (including reasonable attorney’s fees) exceed $1,000, Tenant shall reimburse Landlord for its actual reasonable costs and
expenses in lieu of a fixed review fee. 
 C. Payment to Landlord. If the aggregate consideration paid to a
Tenant Party for a Transfer exceeds that payable by Tenant under this Lease (prorated according to the transferred interest), Tenant shall pay Landlord 50% of such excess (after deducting therefrom reasonable leasing commissions and reasonable costs
of tenant improvements paid to unaffiliated third parties in connection with the Transfer, with proof of same provided to Landlord). Tenant shall pay Landlord for Landlord’s share of any excess within 10 days after Tenant’s receipt of such
excess consideration. If any uncured event of default exists under this Lease, Landlord may require that all sublease payments be made directly to Landlord, in which case Tenant shall receive a credit against Rent in the amount of any payments
received, but not to exceed the amount payable by Tenant under this Lease. 
 D. Change in Control of Tenant. Except
for a Permitted Transfer, if Tenant is a corporation, limited liability company, partnership, or similar entity, and if the entity which owns or controls a majority of the voting shares/rights in Tenant at any time sells or disposes of such majority
of voting shares/rights, or changes its identity for any reason (including a merger, consolidation or reorganization), such change of ownership or control shall constitute a Transfer. The foregoing shall not apply so long as, both before and after
the Transfer, Tenant is an entity whose outstanding stock is listed on a recognized U.S. securities exchange, or if at least 80% of its voting stock is owned by another entity, the voting stock of which is so listed; provided, however, that Tenant
shall give Landlord written notice at least 30 days prior to the effective date of such change in ownership or control. 
 E.
Assignment and Bankruptcy. 
 (1) Assignments after Bankruptcy. If, pursuant to applicable bankruptcy law (as
hereinafter defined), Tenant (or its successor in interest hereunder) is permitted to assign this Lease in disregard of the restrictions contained in this Article 11 (or if this Lease shall be assumed by a trustee for such person), the
trustee or assignee shall cure any default under this Lease and shall provide adequate assurance of future performance by the trustee or assignee, including (i) the source of payment of Base Rent, OE Payment and performance of other obligations
under this Lease (for which adequate assurance shall mean the deposit of cash security with Landlord in an amount equal to the sum of one (I ) year’s Base Rent, OE Payment and other Rent then reserved hereunder for the calendar year preceding
the year in which such assignment is intended to become effective, which deposit shall be held by Landlord, without interest, for the balance of the Term as security for the full and faithful performance of all of the obligations under this Lease on
the part of Tenant yet to be performed and that any such assignee of this Lease shall have a net worth exclusive of good will, computed in accordance with the generally accepted accounting principles, equal to at least ten (10) times the
aggregate of the Base Rent reserved hereunder); and (ii) that the use of the Premises shall be in accordance with the requirements of Article 5 hereof and, 

  
 17 

 
further, shall in no way diminish the reputation of the Building or impose any additional burden upon the Building or increase the services to be provided by Landlord. If all defaults are
not cured and such adequate assurance is not provided within 60 days after there has been an order for relief under applicable bankruptcy law, then this Lease shall be deemed rejected, Tenant or any other person in possession shall immediately
vacate the Premises, and Landlord shall be entitled to retain any Base Rent, OE Payment, and any other Rent, together with any Security Deposit previously received from the Tenant, and shall have no further liability to Tenant or any person claiming
through Tenant or any trustee. For purposes hereof, “bankruptcy law” shall mean the federal Bankruptcy Code or any other present or future federal or state insolvency, bankruptcy or similar law. 

(2) Bankruptcy of Assignee. If Tenant assigns this Lease to any party and such party or its successors or representatives causes
termination or rejection of this Lease pursuant to applicable bankruptcy law, then, notwithstanding any such termination or rejection, Tenant (i) shall remain fully liable for the performance of all covenants, agreements, terms, provisions and
conditions contained in this Lease, as though the assignment never occurred and (ii) shall, without in any way limiting the foregoing, in writing ratify the terms of this Lease, as same existed immediately prior to the termination or rejection.

 F. No Consent Required. Tenant may assign its entire interest under this Lease or sublease all or a portion of the Premises
to its Affiliate (defined below) or to a successor to Tenant by purchase, merger, consolidation or reorganization without the consent of Landlord, provided that all of the following conditions are satisfied in Landlord’s reasonable discretion
(a “Permitted Transfer”): (1) no uncured event of default exists under this Lease; (2) Tenant’s successor shall own all or substantially all of the assets of Tenant; (3) such successor shall
have a net worth which is at least equal to the greater of Tenant’s net worth at the date of this Lease or Tenant’s net worth as of the day prior to the proposed purchase, merger, consolidation or reorganizations; (4) no portion of
the Building or Premises would likely become subject to additional or different Laws as a consequence of the proposed Transfer; (5) such Affiliate’s or successor’s use of the Premises shall not conflict with the Permitted Use or any
exclusive usage rights granted to any other tenant in the Building; (6) neither the Permitted Transfer nor any consideration payable to Landlord in connection therewith adversely affects any real estate investment trust qualification tests
applicable to Landlord or its Affiliates; (7) such Affiliate or successor is not and has not been involved in litigation with Landlord or any of Landlord’s Affiliates; and (8) Tenant shall give Landlord written notice at least 30 days
prior to the effective date of the proposed Permitted Transfer, or if it is not reasonably possible to deliver such notice at least thirty (30) days prior to the effective date of the Permitted Transfer, then within five (5) days following
the effective date of the Permitted Transfer, along with all applicable documentation and other information necessary for Landlord to determine that the requirements of this Section 11.F have been satisfied, including if applicable, the
qualification of such proposed transferee as an Affiliate of Tenant. The term “Affiliate” means any person or entity controlling, controlled by or under common control with Tenant or Landlord, as applicable. If
requested by Landlord, the Affiliate or successor shall sign a commercially reasonable form of assumption agreement. 
 12. Liens.
Tenant shall not permit mechanic’s or other liens to be placed upon the Property, Premises or Tenant’s leasehold interest in connection with any work or service done or purportedly done by or for the benefit of Tenant. If a lien is so
placed, Tenant shall, within 10 days of notice from Landlord of the filing of the lien, fully discharge the lien by settling the claim which resulted in the lien or by bonding or insuring over the lien in the manner prescribed by the applicable lien
Law. If Tenant fails to discharge the lien, then, in addition to any other right or remedy of Landlord, Landlord may bond or insure over the lien or otherwise discharge the lien. Tenant shall, within 30 days after receipt of an invoice from
Landlord, reimburse Landlord for any reasonable amounts paid by Landlord, including reasonable attorneys’ fees, to bond or insure over the lien or discharge the lien. 

  
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 13. Indemnity. Subject to Article 15, Tenant shall hold Landlord, its trustees, Affiliates,
subsidiaries, members, principals, beneficiaries, partners, officers, directors, shareholders, employees, Mortgagee(s) (defined in Article 25) and agents (including the manager of the Property) (collectively, “Landlord
Parties”) harmless from, and indemnify and defend such parties against, all liabilities, obligations, damages, penalties, claims, actions, costs, charges and expenses, including reasonable attorneys’ fees and other professional
fees that may be imposed upon, incurred by or asserted against any of such indemnified parties (each a “Claim” and collectively “Claims”) that arise out of or in connection with any damage or injury suffered by any
third party which occurs in the Premises, EVEN IF THE CLAIM IS CAUSED BY THE NEGLIGENCE OF ANY LANDLORD PARTY, BUT NOT TO THE EXTENT SUCH CLAIM IS CAUSED BY THE GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF ANY LANDLORD PARTY. Subject to
Articles 9.B, 15 and 20, Landlord shall hold Tenant, its trustees, Affiliates, members, principals, beneficiaries, partners, officers, directors, shareholders, employees and agents (collectively, “Tenant
Parties”) harmless from, and indemnify and defend such parties against, all Claims that arise out of or in connection with any drainage or injury suffered by any third party which occurs in or on the Common Areas of the Property, to the
same extent the Tenant Parties would have been covered had they been named as additional insureds on the commercial general liability insurance policy required to be carried by Landlord under this Lease, EVEN IF THE CLAIM IS CAUSED BY THE
NEGLIGENCE OF ANY TENANT PARTY, BUT NOT TO THE EXTENT SUCH CLAIM IS CAUSED BY THE GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF ANY TENANT PARTY. This Article 13 shall survive the expiration or earlier termination of this Lease. 

14. Insurance. 
 A.
Tenant’s Insurance. 
 (1) Liability Insurance. Tenant shall procure and maintain at its own cost policies of
commercial general public liability and property damage insurance with contractual liability coverage for the agreements of indemnity provided for under this Lease and a broad form general liability endorsement to afford protection which provides,
on an occurrence basis, a minimum combined single limit of no less than $3,000,000 (coverage in excess of $1,000,000 may be provided by way of an umbrella/excess liability policy) insuring Landlord, the Landlord Parties and Tenant from all claims,
demands or actions for injury to or death of any person or persons and for damage to property made by Tenant, its employees, agents, contractors, guests and invitees. The insurance shall be written by companies licensed to write insurance in the
jurisdiction where the Property is located, provided such companies have a Best’s financial strength/financial size category minimum rating of “A-/VII” or better in the most recent edition of Best’s Insurance Report
or as otherwise approved by Landlord and Tenant if such rating system shall be modified or discontinued and shall name Landlord and Landlord’s management agent (and, if requested by Landlord or any mortgagee, include any mortgagee) and their
respective agents and employees as additional insureds. The aforesaid insurance policies shall provide that they shall not be subject to cancellation except after at least thirty (30) days’ prior written notice to Landlord and all such
mortgagees (unless such cancellation is due to non-payment of premiums, in which event ten (10) days’ prior written notice shall be required). The original insurance policies (or certificates thereof satisfactory to Landlord), together
with applicable endorsements (including, without limitation, an endorsement indicating the additional insureds) and satisfactory evidence of payment of the premium thereon, shall be deposited with Landlord prior to the commencement of the Term and
renewals thereof not less than five (5) Business Days prior to the end of the term of each such coverage. 
 (2) Casualty
Insurance. Tenant shall carry causes of loss — special form (formerly referred to as “all risk”) property insurance, including water damage, insuring its interest in the tenant improvements in the Premises (to the extent not
covered by Landlord’s property insurance) and its 

  
 19 

 
interest in all its personal property and trade fixtures located on or within the Building (collectively, “Tenant’s Property”), including, without limitation, its
office furniture, equipment and supplies, and all above building standard leasehold improvements. 
 (3) Increase in Coverage.
Not more frequently than every 2 years, Landlord may, by notice to Tenant, require an increase in the above-described limits of coverage if, in the reasonable opinion of Landlord, the amount of liability insurance specified in this Article 14 is not
reasonably adequate to maintain the level of insurance protection at least equal to the protection afforded on the date the Term commences. If Tenant fails to maintain and secure the insurance coverage required under this Article then Landlord shall
have, in addition to all other remedies provided herein and by Law, the right, but not the obligation, to procure and maintain such insurance, the cost of which shall be due and payable to Landlord by Tenant within ten (10) business days after
written demand. 
 B. Landlord’s Insurance. Landlord shall maintain: (1) commercial general liability insurance
applicable to the Property which provides, on an occurrence basis, a minimum combined single limit of no less than $3,000,000 (coverage in excess of $1,000,000 may be provided by way of an umbrella/excess liability policy); (2) causes of
loss-special form (formerly “all risk”) property insurance on the Building in the amount of the replacement cost thereof; and (3) such other insurance as Landlord reasonably deems necessary or desirable for the Property, which may
include, without limitation, earthquake, terrorism, and environmental insurance coverage. The foregoing insurance and any other insurance carried by Landlord may be effected by self-insurance or a policy or policies of blanket insurance and shall be
for the sole benefit of Landlord and under Landlord’s sole control. Consequently, Tenant shall have no right or claim to any proceeds thereof or any other rights thereunder. 

C. Increased Costs. Tenant shall not conduct or permit to be conducted by its employees, agents, guests or invitees any
activity, or place any equipment in or about the Premises or the Building that will in any way increase the cost of fire insurance or other insurance on the Building. If any increase in the cost of fire insurance or other insurance is stated by any
insurance company or by the applicable Insurance Rating Bureau, if any, to be due to any activity or equipment of Tenant in or about the Premises or the Building, such statement shall be conclusive evidence that the increase in such cost is due to
such activity or equipment and, as a result thereof, Tenant shall be liable for the amount of such increase. Tenant shall reimburse Landlord for such amount upon written demand from Landlord and any such sum shall be considered additional Rent
payable hereunder. Tenant, at its sole expense, shall comply with any and all requirements of any insurance organization or company necessary for the maintenance of reasonable fire and public liability insurance covering the Premises and the
Building. 
 15. Mutual Waiver of Subrogation. Notwithstanding anything to the contrary contained in this Lease, Landlord and Tenant
each hereby waives any rights it may have against the other (including, but not limited to, a direct action for damages) on account of any loss or damage occasioned to Landlord or Tenant, as the case may be to their respective property, the
Premises, its contents or to any other po1tion of the Building or the Property arising from any risk (without regard to the amount of coverage or the amount of deductible) covered by the causes of loss — special form full replacement cost
property insurance required to be carried by Tenant and Landlord, respectively under Article 14 above, EVEN IF (i) SUCH LOSS OR DAMAGE IS CAUSED BY THE FAULT, NEGLIGENCE OR OTHER TORTIOUS CONDUCT, ACTS OR OMISSIONS OF THE RELEASED PARTY OR
THE RELEASED PARTY’S DIRECTORS, EMPLOYEES, AGENTS OR INVITEES, OR (ii) THE RELEASED PARTY IS STRICTLY LIABLE FOR SUCH LOSS OR DAMAGE. The foregoing waiver shall be effective even if either or both parties fail to carry the insurance
required by Article 14 above. If a party waiving rights under this Section is carrying a causes of loss -special form full replacement cost insurance policy in the promulgated form used in the State of Texas and an amendment to such promulgated form
is passed, such amendment shall be deemed not a part of such promulgated 

  
 20 

 
form until it applies to the policy being carried by the waiving party. Without in any way limiting the foregoing waivers and to the extent permitted by applicable Law, the parties hereto each,
on behalf of their respective insurance companies insuring the property of either Landlord or Tenant against any such loss, waive any right of subrogation that Landlord or Tenant or their respective insurers may have against the other party or their
respective officers, directors, employees, agents or invitees and all rights of their respective insurance companies based upon an assignment from its insured. Each party to this Lease agrees immediately to give to each such insurance company
written notification of the terms of the mutual waivers contained in this Section and to have said insurance policies properly endorsed, if necessary, to prevent the invalidation of said insurance coverage by reason of said waivers. For the purpose
of the foregoing waiver, the amount of any deductible applicable to any loss or damage shall be deemed covered by, and recoverable by the insured under the insurance policy to which such deductible relates. 

16. Casualty Damage. 
 A.
Repair or Termination by Landlord. If all or any part of the Premises are damaged by fire or other casualty, Tenant shall immediately notify Landlord in writing. Landlord shall have the right to terminate this Lease if: (1) the
Building shall be damaged so that, in Landlord’s judgment, substantial alteration or reconstruction of the Building shall be required (whether or not the Premises have been damaged); (2) Landlord is not permitted by Law to rebuild the
Building in substantially the same form as existed before the fire or casualty; (3) the Premises have been materially damaged and there is less than 2 years of the Term remaining on the date of the casualty; (4) any Mortgagee requires that
the insurance proceeds be applied to the payment of the mortgage debt; or (5) an uninsured loss of the Building occurs notwithstanding Landlord’s compliance with Section 14.B above; provided, however, that Landlord shall be
entitled to terminate this Lease under this Section 16.A. only if Landlord simultaneously terminates the leases of all other tenants and occupants of the Building similarly affected by the fire or other casualty. Landlord may exercise
its right to terminate this Lease by notifying Tenant in writing within 60 days after the date of the casualty. If Landlord does not terminate this Lease under this Section 16.A, Landlord shall commence and proceed with reasonable
diligence to repair and restore the Building and/or the Premises to substantially the same condition as existed immediately prior to the date of damage; provided, however, that Landlord shall only be required to reconstruct Building standard
leasehold improvements existing in the Premises as of the date of damage, and Tenant shall be required to pay the cost for restoring any other leasehold improvements. However, in no event shall Landlord be required to spend more than the insurance
proceeds received by Landlord. 
 B. Timing for Repair; Termination by Either Party. If all or any portion of the
Premises is damaged as a result of fire or other casualty, Landlord shall, with reasonable promptness, cause an architect or general contractor selected by Landlord to provide Landlord and Tenant with a written estimate of the amount of time
required to substantially complete the repair and restoration of the Premises, using standard working methods (“Completion Estimate”). If the Completion Estimate indicates that the Premises cannot be made
tenantable within 180 days from the date of damage, then regardless of anything in Section 16.A above to the contrary, either party shall have the right to terminate this Lease by giving written notice to the other of such election
within I 0 days after receipt of the Completion Estimate. Tenant, however, shall not have the right to terminate this Lease if the fire or casualty was caused by the gross negligence or intentional misconduct of any of the Tenant Parties. If neither
party terminates this Lease under this Section 16.B, then Landlord shall repair and restore the Premises in accordance with, and subject to the limitations of, Section 16.A. 

C. Abatement. In the event a material portion of the Premises is damaged as a result of a fire or other casualty, the Base Rent
shall abate for the portion of the Premises that is damaged and not usable by Tenant until substantial completion of the repairs and restoration required to be made by Landlord pursuant to Section 16.A. Tenant, however, shall not be
entitled to such abatement if the fire or  

  
 21 

 
other casualty was caused by the gross negligence or intentional misconduct of any of the Tenant Parties. Landlord shall not be liable for any loss or damage to Tenant’s Property or to the
business of Tenant resulting in any way from the fire or other casualty or from the repair and restoration of the damage. Landlord and Tenant hereby waive the provisions of any Law relating to the matters addressed in this Article, and agree that
their respective rights for damage to or destruction of the Premises shall be those specifically provided in this Lease. 
 17. Condemnation.
Either party may terminate this Lease if the whole or any material part of the Premises are taken or condemned for any public or quasi-public use under Law, by eminent domain or private purchase in lieu thereof (a “Taking”).
Landlord shall also have the right to terminate this Lease if there is a Taking of any portion of the Building or Property which would leave the remainder of the Building unsuitable for use as an office building in a manner comparable to the
Building’s use prior to the Taking. In order to exercise its right to terminate this Lease under this Article 17, Landlord or Tenant, as the case may be, must provide written notice of termination to the other within 45 days after the
terminating party first receives notice of the Taking. Any such termination shall be effective as of the date the physical taking of the Premises or the portion of the Building or Property occurs. If this Lease is not terminated, the Rentable Square
Footage of the Building, the Rentable Square Footage of the Premises and Tenant’s Pro Rata Share shall, if applicable, be appropriately adjusted by Landlord. In addition, Base Rent for any portion of the Premises taken or condemned shall be
abated during the unexpired Term effective when the physical taking of the portion of the Premises occurs. All compensation awarded for a Taking, or sale proceeds, shall be the property of Landlord, any right to receive compensation or proceeds
being expressly waived by Tenant. However, Tenant may file a separate claim at its sole cost and expense for Tenant’s Property (excluding above building standard leasehold improvements) and Tenant’s reasonable relocation expenses, provided
the filing of such claim does not diminish the award which would otherwise be receivable by Landlord. 
 18. Events of Default. Tenant shall
be considered to be in default under this Lease upon the occurrence of any of the following events of default: 
 A.
Tenant’s failure to pay when due all or any portion of the Rent (“Monetary Default”); provided that the first two (2) such failures during any consecutive twelve (12) month period during the
Term shall not be an event of Monetary Default if Tenant pays the amount due within five (5) Business Days after Tenant’s receipt of written notice from Landlord that such payments were not made when due. 

B. Tenant’s failure to perform any of the obligations of Tenant in the manner set forth in
Articles 14, 24 or 25 and such failure continues for a period of five (5) Business Days following Landlord’s written notice thereof to
Tenant (a “Time Sensitive Default”). 
 C. Tenant’s failure (other than a Monetary Default
or a Time Sensitive Default) to comply with any term, provision or covenant of this Lease, if the failure is not cured within 30 days after written notice to Tenant. However, if Tenant’s failure to comply cannot reasonably be cured within 30
days, Tenant shall be allowed additional time (not to exceed an additional 30 days) as is reasonably necessary to cure the failure so long as: (1) Tenant commences to cure the failure within the 30 day period following Landlord’s initial
written notice, and (2) Tenant diligently pursues a course of action that will cure the failure and bring Tenant back into compliance with this Lease. However, if Tenant’s failure to comply creates a hazardous condition, the failure must
be cured immediately upon notice to Tenant. In addition, if Landlord provides Tenant with notice of Tenant’s failure to comply with the same specific term, provision or covenant of this Lease on more than two (2) occasions during any
12month period, Tenant’s subsequent violation of the same term, provision or covenant shall, at Landlord’s option, be deemed an incurable event of default by Tenant. 

  
 22 

 D. Tenant or any Guarantor becomes insolvent, files a petition for protection under the
U.S. Bankruptcy Code (or similar Law) or a petition is filed against Tenant or any Guarantor under such Laws and is not dismissed within 45 days after the date of such filing, makes a transfer in fraud of creditors or makes an assignment for the
benefit of creditors, or admits in writing its inability to pay its debts when due. 
 E. The leasehold estate is taken by process or
operation of Law. 
 F. Intentionally omitted. 

G. Tenant is in default beyond any notice and cure period under any other lease or agreement with Landlord for the Property, including
any lease or agreement for parking. 
 19. Remedies. 

A. Landlord’s Remedies. Upon any default, Landlord shall have the right without notice or demand (except as provided in
Article 18) to pursue any of its rights and remedies at Law or in equity, including any one or more of the following remedies: 
 (1)
Terminate this Lease; 
 (2) Re-enter the Premises, change locks, alter security devices and lock out Tenant or terminate Tenant’s
right of possession of the Premises without terminating this Lease; 
 (3) Remove and dispose of or store, at Tenant’s expense, all the
property in the Premises using such lawful force as may be necessary; 
 (4) Cure such event of default for Tenant at Tenant’s expense
(plus a 10% administrative fee); 
 (5) Withhold or suspend payment of sums Landlord would otherwise be obligated to pay to Tenant under
this Lease or any other agreement until such default is cured; 
 (6) Require all future Rent payments to be made by cashier’s check,
money order or wire transfer after the first time any check is returned for insufficient funds, or the second time any sum due hereunder is more than five (5) days late; 

(7) Apply any Security Deposit as permitted under this Lease; and/or 

(8) Recover such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time by applicable Law, including
any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of events would be likely to result there from. 

If Landlord terminates Tenant’s possession of the Premises under this Article 19, (i) Landlord shall have no obligation
whatsoever to tender to Tenant a key for new locks installed in the Premises, (ii) Tenant shall have no further right to possession of the Premises and (iii) Landlord will have the right to relet the Premises or any part thereof on such
terms as Landlord deems advisable. Further, upon Landlord’s termination of Tenant’s possession or this Lease under this Article 19, Landlord may, without notice, remove and either dispose of or store, at Tenant’s expense, any
property belonging to Tenant that remains in the Premises after Landlord has regained possession thereof. Tenant acknowledges that the 

  
 23 

 
provisions of this subsection of this Lease supersede the Texas Property Code. TENANT EXPRESSLY WAIVES THE SERVICE OF ANY STATUTORY DEMAND OR NOTICE WHICH IS A PREREQUISITE TO LANDLORD’S
COMMENCEMENT OF EVICTION PROCEEDINGS AGAINST TENANT, INCLUDING THE DEMANDS AND NOTICES SPECIFIED IN ANY APPLICABLE STATE STATUTE OR CASE LAW. TENANT KNOWINGLY AND VOLUNTARILY WAIVES ANY RIGHT TO TRIAL BY JURY IN ANY LAWSUIT BROUGHT BY LANDLORD TO
RECOVER POSSESSION OF THE PREMISES FOLLOWING LANDLORD’S TERMINATION OF THIS LEASE OR THE RIGHT OF TENANT TO POSSESSION OF THE PREMISES PURSUANT TO THE TERMS OF THIS LEASE AND ON ANY CLAIM FOR DELINQUENT RENT WHICH LANDLORD MAY JOIN IN ITS
LAWSUIT TO RECOVER POSSESSION. LANDLORD IS HEREBY AUTHORIZED TO FILE A COPY OF THIS PARAGRAPH IN ANY PROCEEDING AS CONCLUSIVE EVIDENCE OF THE FOREGOING WAIVER. 

B. Measure of Damages. 

(1) Calculation. If Landlord either terminates this Lease or terminates Tenant’s right to possession of the Premises, Tenant
shall immediately surrender and vacate the Premises and pay Landlord on demand: (a) all Rent accrued through the end of the month in which the termination becomes effective; (b) interest on all unpaid Rent from the date due at a rate equal
to the lesser of 15% per annum or the highest interest rate permitted by applicable Law; (c) all expenses reasonably incurred by Landlord in enforcing its rights and remedies under this Lease, including all reasonable legal expenses;
(d) Costs of Reletting (defined below); and (e) if Landlord terminates this Lease, all Landlord’s Rental Damages (defined below). In the event that Landlord relets the Premises for an amount greater than the Rent due during the Term,
Tenant shall not receive a credit for any such excess. 
 (2) Definitions. “Costs of Reletting” shall
include commercially reasonable costs, losses and expenses incurred by Landlord in reletting all or any portion of the Premises including, without limitation, the cost of removing and storing Tenant’s furniture, trade fixtures, equipment,
inventory or other property, repairing and/or demolishing the Premises, removing and/or replacing Tenant’s signage and other fixtures, making the Premises ready for a new tenant, including the cost of advertising, commissions, architectural
fees, legal fees and leasehold improvements, and any allowances and/or concessions provided by Landlord. “Landlord’s Rental Damages” shall mean the total Rent which Landlord would have received under this Lease (had
Tenant made all such Lease payments as required) for the remainder of the Term minus the fair rental value of the Premises for the same period, or, if the Premises are relet, the actual rental value (not to exceed the Rent due during the Term), both
discounted to present value at eight percent (8%) per annum. 
 C. Tenant Not Relieved from Liabilities. Unless expressly
provided in this Lease, the repossession or re-entering of all or any part of the Premises shall not relieve Tenant of its liabilities and obligations under this Lease. In addition, Tenant shall not be relieved of its liabilities under this Lease,
nor be entitled to any damages hereunder, based upon minor or immaterial errors in the exercise of Landlord’s remedies. No right or remedy of Landlord shall be exclusive of any other right or remedy. Each right and remedy shall be cumulative
and in addition to any other right and remedy now or subsequently available to Landlord at Law or in equity. If Tenant fails to pay any amount when due hereunder (after the expiration of any applicable cure period), Landlord shall be entitled to
receive interest on any unpaid item of Rent from the date that is thirty (30) days after the date initially due (without regard to any applicable grace period) at a rate equal to the lesser of 15% per annum or the highest rate permitted by
Law. In addition, if Tenant fails to pay any item or installment of Rent when due (after the expiration of any applicable cure period), Tenant shall pay Landlord an administrative fee equal to 5% of the past due Rent; provided, however, Landlord
shall not charge an administrative fee on the first two (2) late 

  
 24 

 
payments of Rent in any twelve (12) month period so long as Tenant makes such payments within five (5) Business Days after receipt of notice from Landlord of such failure. However, in
no event shall the charges permitted under this Section 19.C or elsewhere in this Lease, to the extent they are considered interest under applicable Law, exceed the maximum lawful rate of interest. If any payment by Tenant of an amount
deemed to be interest results in Tenant having paid any interest in excess of that permitted by Law, then it is the express intent of Landlord and Tenant that all such excess amounts theretofore collected by Landlord be credited against the other
amounts owing by Tenant under this Lease. Receipt by Landlord of Tenant’s keys to the Premises shall not constitute an acceptance or surrender of the Premises. 

D. Mitigation of Damages. Upon termination of Tenant’s right to possess the Premises, Landlord shall, only to the extent
required by Law, use objectively reasonable efforts to mitigate damages by reletting the Premises. Landlord shall not be deemed to have failed to do so if Landlord refuses to lease the Premises to a prospective new tenant with respect to whom
Landlord would be entitled to withhold its consent pursuant to Section 11.A, or who (1) is an Affiliate, parent or subsidiary of Tenant; (2) is not acceptable to any Mortgagee of Landlord; (3) requires improvements to the
Premises to be made at Landlord’s expense; or (4) is unwilling to accept lease terms then proposed by Landlord, including: (a) leasing for a shorter or longer term than remains under this Lease; (b) re-configuring or combining
the Premises with other space, (c) taking all or only a part of the Premises; and/or (d) changing the use of the Premises. Notwithstanding Landlord’s duty to mitigate its damages as provided herein, Landlord shall not be obligated
(i) to give any priority to reletting Tenant’s space in connection with its leasing of space in the Building or any complex of which the Building is a part, or (ii) to accept below market rental rates for the Premises or any rate that
would negatively impact the market rates for the Building. To the extent that Landlord is required by applicable Law to mitigate damages, Tenant must plead and prove by clear and convincing evidence that Landlord failed to so mitigate in accordance
with the provisions of this Section 19.D, and that such failure resulted in an avoidable and quantifiable detriment to Tenant. 

E. Landlord Defaults. Except as otherwise provided in this Lease and specifically subject to Sections 3.B and 20,
if Landlord fails in the performance of any of Landlord’s obligations under this Lease and such failure continues for thirty (30) days after Landlord’s receipt of written notice thereof from Tenant (or an additional reasonable time
after such receipt if (i) such failure cannot be cured within such thirty (30) day period, and (ii) Landlord commences curing such failure within such thirty (30) day period and thereafter diligently pursues the curing of such
failure), then Tenant shall be entitled to exercise any remedies that Tenant may have at law or in equity. 
 20. Limitation of Liability.

 A. Notwithstanding anything to the contrary contained in this Lease, the liability of Landlord (and of any successor Landlord) to
Tenant (or any person or entity claiming by, through or under Tenant) shall be limited to the interest of Landlord in the Property, including, without limitation, all rents, security deposits, insurance proceeds, condemnation awards and proceeds
from the sale, lease or other disposition of Landlord’s interest in the Property. Tenant shall look solely to Landlord’s interest in the Property for the recovery of any judgment or award against Landlord. No Landlord Party shall be
personally liable for any judgment or deficiency. Before filing suit for an alleged default by Landlord, Tenant shall give Landlord and the Mortgagee(s) (defined in Article 25) whom Tenant has been notified hold Mortgages (defined in
Article 25) on the Property, Building or Premises, notice and reasonable time to cure the alleged default. Tenant is granted no contractual right of termination by this Lease, except to the extent and only to the extent set forth in
Articles 16 and 17 above. Tenant hereby waives all claims against all Landlord Parties for consequential, special or punitive damages allegedly suffered by any Tenant Parties, including lost profits and business interruption. TENANT
HEREBY WAIVES ITS STATUTORY LIEN UNDER SECTION 91.004 OF THE TEXAS PROPERTY CODE. 

  
 25 

 B. UNLESS COVERED BY SECTION 13 ABOVE OR CAUSED BY LANDLORD’S GROSS NEGLIGENCE OR WILLFUL
MISCONDUCT AND WITHOUT LIMITING THE PROVISIONS OF ARTICLE 15, LANDLORD SHALL NOT BE LIABLE TO TENANT FOR ANY CLAIMS, ACTIONS, DEMANDS, COSTS, EXPENSES, DAMAGE OR LIABILITY OF ANY KIND (i) arising out of the use, occupancy or enjoyment of
the Premises by Tenant or any person therein or holding under Tenant or by or through the acts or omissions of any of their respective employees, officers, agents, invitees or contractors, (ii) caused by or arising out of fire, explosion,
falling sheetrock, gas, electricity, water, rain, snow or dampness, or leaks in any part of the Premises, (iii) caused by or arising out of damage to the roof, pipes, appliances or plumbing works or any damage to or malfunction of heating,
ventilation or air conditioning equipment, (iv) caused by tenants or any persons either in the Premises or elsewhere in the Building (other than Common Areas) or by occupants of property adjacent to the Building or Common Areas or
(v) caused by any act, neglect or negligence of Tenant. In no event shall Landlord be liable to Tenant for any loss of or damage to property of Tenant or of others located in the Premises, the Building or any other part of the Property by
reason of theft or burglary. 
 21. No Waiver. Neither party’s failure to declare a default immediately upon its occurrence or delay in
taking action for a default shall constitute a waiver of the default, nor shall it constitute an estoppel. Neither party’s failure to enforce its rights for a default shall constitute a waiver of that party’s rights regarding any
subsequent default. 
 22. Tenant’s Right to Possession. Provided Tenant pays the Rent and is not in default hereunder beyond any
applicable cure period, Tenant shall have the right to occupy the Premises without hindrance from Landlord or any person lawfully claiming through Landlord, subject to the terms of this Lease, all Mortgages, insurance requirements and applicable
Law. This covenant and all other covenants of Landlord shall be binding upon Landlord and its successors only during its or their respective periods of ownership of the Building, and shall not be a personal covenant of any Landlord Parties. Landlord
represents and warrants to Tenant that no restrictive covenant or other recorded matter that affects the Premises prohibits the use of the Premises for the Permitted Use. 

23. Relocation. Upon 120 days advance written notice to Tenant (the “Relocation Notice”), Landlord shall have the right
to relocate Tenant to other space in the Building (the “Substitute Premises”) provided such other space is equal in size to or larger in size than the Premises and contains the same number of work stations, offices,
breakrooms and reception areas as are contained in the Premises as of the date Tenant receives the Relocation Notice and provided that the total monthly Base Rent for the Substitute Premises shall in no event exceed the total monthly Base Rent for
the Premises prior to the relocation and Tenant’s Pro Rata Share for the Substitute Premises shall in no event exceed Tenant’s Pro Rata Share for the Premises prior to the relocation. Landlord shall pay all reasonable third party
out-of-pocket expenses of any such relocation, including the expenses of moving and construction of improvements substantially similar to Landlord Work and other improvements installed with the written consent of Landlord and prior to the date of
the Relocation Notice and the expense of installing and connecting Cable in the Substitute Premises in the manner and to the extent such Cable existed in the Premises prior to the relocation, subject to the condition that Landlord shall have the
right to use all or any of Landlord Work and such other improvements (including Cable) in connection with the construction of the improvements in the Substitute Premises. In the event of such relocation, this Lease shall continue in full force and
effect without any change in the terms or other conditions, except that the Substitute Premises shall be the Premises and an Exhibit A-1 showing the Substitute Premises shall be substituted for the Exhibit A-1 attached
hereto. If requested by Landlord, Tenant shall execute an amendment to this Lease evidencing the foregoing. 

  
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 24. Holding Over. If Tenant or any party claiming by, through or under Tenant fails to surrender
the Premises at the expiration or earlier termination of this Lease, the continued occupancy of the Premises shall be that of a tenancy at sufferance. Tenant shall pay an amount (on a per month basis without reduction for partial months during the
holdover) equal to 150%of the sum of the Base Rent and the OE Payment due for the period immediately preceding the holdover. Tenant shall otherwise continue to be subject to all of Tenant’s obligations under this Lease. No holdover by Tenant or
payment by Tenant after the expiration or early termination of this Lease shall be construed to extend the Term or prevent Landlord from immediate recovery of possession of the Premises by summary proceedings or otherwise. In addition to the payment
of the amounts provided above, if Landlord is unable to deliver possession of the Premises to a new tenant, or to perform improvements for a new tenant as a result of Tenant’s holdover, such failure shall constitute a Time Sensitive Default
hereunder; and notwithstanding any other provision of this Lease to the contrary, Tenant shall be liable to Landlord for, and shall protect Landlord from and indemnify and defend Landlord against, all losses and damages, including any claims made by
any succeeding tenant resulting from such failure to vacate, and any consequential damages that Landlord suffers from the holdover. 
 25.
Subordination to Mortgages; Estoppel Certificate. Tenant accepts this Lease subject and subordinate to any mortgage(s), deed(s) of trust, ground lease(s) or other lien(s) now or subsequently affecting the Premises, the Building or the
Property, and to renewals, modifications, refinancings and extensions thereof (collectively, a “Mortgage”). The party having the benefit of a Mortgage shall be referred to as a “Mortgagee.” This clause
shall be self-operative, but upon request from Landlord or a Mortgagee, Tenant shall execute a commercially reasonable subordination agreement in favor of the Mortgagee. In lieu of having the Mortgage be superior to this Lease, a Mortgagee shall
have the right at any time to subordinate its Mortgage to this Lease. If requested by a successor-in-interest to all or a part of Landlord’s interest in this Lease, Tenant shall, without charge, attorn to the
successor-in-interest. Tenant shall, within 10 days after receipt of a written request from Landlord, execute and deliver an estoppel certificate to those parties as are reasonably requested by Landlord
(including a Mortgagee or prospective purchaser). The estoppel certificate shall include a statement certifying that this Lease is unmodified (except as identified in the estoppel certificate) and in full force and effect, describing the dates to
which Rent and other charges have been paid, representing that, to the best of Tenant’s knowledge, there is no default (or stating with specificity the nature of the alleged default) and certifying other matters with respect to this Lease that
may reasonably be requested. Tenant’s failure to provide any estoppel certificate within the 10 day period specified above, and the continuation of such failure for a period of 5 days after Landlord delivers a second written notice requesting
same, shall be deemed to be Tenant’s acknowledgement that the items listed in the estoppel certificate are true. Landlord will use reasonable efforts to obtain a non-disturbance, subordination and attornment agreement from
Landlord’s current Mortgagee on such Mortgagee’s then current standard form of agreement. “Reasonable efforts” of Landlord shall not require Landlord to incur any cost, expense or liability to obtain such agreement, it being
agreed that Tenant shall be responsible for any fee or review costs charged by the Mortgagee. Landlord’s failure to obtain a non-disturbance, subordination and attornment agreement for Tenant shall have no effect on the rights, obligations and
liabilities of Landlord and Tenant or be considered to be a default by Landlord hereunder. 
 26. Attorneys’ Fees. If either party
institutes a suit against the other for violation of or to enforce any covenant or condition of this Lease, or if either party intervenes in any suit in which the other is a party to enforce or protect its interest or rights, the prevailing party
shall be entitled to all of its costs and expenses, including reasonable attorneys’ fees. In addition, if, on account of any breach or default by Tenant in Tenant’s obligations under the terms and conditions of this Lease, it shall become
necessary or appropriate for Landlord to employ or consult with any attorney concerning or to enforce or defend any of Landlord’s rights or remedies hereunder, Tenant agrees to pay any reasonable attorney’s fees so incurred. 

  
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 27. Notice. If a demand, request, approval, consent or notice (collectively, a
“notice”) shall or may be given to either party by the other, the notice shall be in writing and delivered by hand or sent by registered or certified mail with return receipt requested, or sent by overnight or same day
courier service, or sent by facsimile, at the party’s respective Notice Address(es) set forth in Article 1, except that if Tenant has vacated the Premises (or if the Notice Address for Tenant is other than the Premises, and Tenant
has vacated such address) without providing Landlord a new Notice Address, Landlord may serve notice in any manner described in this Article or in any other manner permitted by Law. Each notice shall be deemed to have been received or given on the
earlier to occur of actual delivery (which, in the case of delivery by facsimile, shall be deemed to occur at the time of delivery indicated on the electronic confirmation of the facsimile) or the date on which delivery is first refused, or, if
Tenant has vacated the Premises or the other Notice Address of Tenant without providing a new Notice Address, three (3) days after notice is deposited in the U.S. mail or one (I) business day after such notice is deposited with a courier
service in the manner described above. Either party may, at any time, change its Notice Address by giving the other party written notice of the new address in the manner described in this Article. 

28. Reserved Rights. This Lease does not grant any rights to light or air over or about the Building. Except as expressly provided herein,
Landlord excepts and reserves exclusively to itself the use of: (A) roofs, (B) telephone, electrical and janitorial closets, (C) equipment rooms, Building risers or similar areas that are used by Landlord for the provision of Building
services, (D) rights to the land and improvements below the floor of the Premises, (E) the improvements and air rights above the Premises, (F) the improvements and air rights outside the demising walls of the Premises, (G) the
areas within the Premises used for the installation of utility lines and other installations serving occupants of the Building, and (H) any other areas designated from time to time by Landlord as service areas of the Building. Other than
equipment generally used for the Permitted Use (such as computers, copiers, and fax machines), Tenant shall not have the right to install or operate any equipment producing radio frequencies, electrical or electromagnetic output or other signals,
noise or emissions in or from the Building without the prior written consent of Landlord. To the extent permitted by applicable Law, Landlord reserves the right to restrict and control the use of such equipment. Landlord has the right to change the
Building’s name or address. Landlord also has the right to make such other changes to the Property and Building as Landlord deems appropriate, provided the changes do not materially affect Tenant’s ability to use the Premises for the
Permitted Use. Landlord shall also have the right (but not the obligation) to temporarily close the Building if Landlord reasonably determines that there is an imminent danger of significant damage to the Building or of personal injury to
Landlord’s employees or the occupants of the Building. The circumstances under which Landlord may temporarily close the Building shall include, without limitation, electrical interruptions, hurricanes and civil disturbances. A closure of the
Building under such circumstances shall not constitute a constructive eviction nor entitle Tenant to an abatement or reduction of Rent. 
 29.
Surrender of Premises. All improvements to the Premises installed as Landlord Work or Alterations (collectively, “Leasehold Improvements”) shall be owned by Landlord and shall remain upon the Premises without compensation to
Tenant. Notwithstanding the foregoing, Landlord may, at any time prior to the expiration date of this Lease, or in the event of a termination of this Lease prior to the scheduled expiration date, within one (1) month after, or earlier
termination of this Lease or Tenant’s right to possession of the Premises, require Tenant to remove any Leasehold Improvements at Tenant’s sole cost upon written notice delivered to Tenant no later than thirty (30) days prior to the
then-scheduled expiration date, or within one (1) month after the earlier termination of this Lease or Tenant’s right of possession of the Premises, as applicable; provided, however, in no event shall Tenant be required to remove any
Leasehold Improvements unless Landlord notified Tenant of such requirement at the time Landlord consented to such Leasehold Improvements. At the expiration or earlier termination of this Lease or Tenant’s right of possession, Tenant shall
remove Tenant’s Removable Property (defined below) from the Premises, and quit and surrender the Premises to Landlord, broom clean, and in good order, 

  
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condition and repair, ordinary wear and tear excepted, together with all keys and parking and access cards. As used herein, the term “Tenant’s Removable Property” shall mean:
(A) all of Tenant’s trade fixtures, equipment, furniture and other personal property within the Premises; (B) any Leasehold Improvements that Landlord requires Tenant to remove; and (C) all Cable installed by or for the exclusive
benefit of Tenant and located in the Premises or other portions of the Building. Tenant shall, at its sole cost and expense, repair any damage caused by such removal. If Tenant fails to remove any of Tenant’s Removable Property on or before the
expiration or earlier termination of this Lease or Tenant’s right to possession of the Premises, or to perform any required repairs and restoration, (i) such property shall be deemed abandoned by Tenant, and title to such property (except
with respect to any Hazardous Material [defined in Article 30]) shall be deemed to be immediately vested in Landlord, (ii) Landlord, at Tenant’s sole cost and expense, may remove such property (and repair any damage
occasioned thereby) and dispose thereof, or store the same, and Tenant shall pay the cost of such removal, repair, or storage of such items within 5 days after demand from Landlord, and (iii) such failure shall be deemed a holding over by
Tenant under Section 24 hereof until such failure is rectified by Tenant or Landlord. 
 30. Hazardous Materials. Tenant
covenants and agrees that it shall not cause or permit any Hazardous Material (as defined below) to be brought upon, kept, or used in or about the Premises or Building by Tenant, its agents, employees, contractors or licensees. The foregoing
covenant shall not extend to substances typically found or used in general office applications so long as (i) such substances and any equipment which generates such substances are maintained only in such quantities as are reasonably necessary
for Tenant’s operations in the Premises, (ii) such substances are used strictly in accordance with the manufacturers’ instructions therefor, (iii) such substances are not disposed of in or about the Building in a manner which
would constitute a release or discharge thereof, and (iv) all such substances and any equipment which generates such substances are removed from the Building by Tenant upon the expiration or earlier termination of this Lease. Any use, storage,
generation, disposal, release or discharge by Tenant of Hazardous Materials in or about the Building as is permitted pursuant to this Article 30 shall be carried out in compliance with all applicable Laws. 

Upon any violation of the foregoing covenants, Tenant shall be obligated, at Tenant’s sole cost, to clean-up and remove from the Building
all Hazardous Materials introduced into the Building by Tenant or Tenant’s employees, agents, contractors, licensees, subtenants, assigns, and vendors. Such clean-up and removal shall include all testing and investigation required by any
governmental authorities having jurisdiction and preparation and implementation of any remedial action plan required by any governmental authorities having jurisdiction. All such clean-up and removal activities of Tenant shall, in each instance, be
conducted to the satisfaction of Landlord and all governmental authorities having jurisdiction. Landlord’s right of entry pursuant to Article 10 above shall include the right to enter and inspect the Premises for violations of
Tenant’s covenants herein. 
 Tenant shall indemnify, defend and hold harmless Landlord and the Landlord Parties from and against any
and all claims, liabilities, losses, actions, costs and expenses (including reasonable attorneys’ fees and costs of defense) incurred by such indemnified persons, or any of them, as the result of (i) the introduction into or about the
Building by Tenant, or any of Tenant’s employees, agents, contractors, licensees, subtenants, assigns, and vendors, of any Hazardous Materials, (ii) the usage, storage, maintenance, generation, disposition or disposal by Tenant, or any of
Tenant’s employees, agents, contractors, licensees, subtenants, assigns, and vendors, of Hazardous Materials in or about the Building, (iii) the discharge or release in or about the Building by Tenant, or any of Tenant’s employees,
agents, contractors, licensees, subtenants, assigns, and vendors, of any Hazardous Materials, (iv) any injury to or death of persons or damage to or destruction of property resulting from the use, introduction, maintenance, storage, generation.
disposal, disposition, release or discharge by Tenant, or any of Tenant’s employees, agents, contractors, licensees, subtenants, assigns, and vendors, of Hazardous Materials in or about the Building, and (v) any failure of Tenant, or any
of Tenant’s employees, agents, contractors, licensees, subtenants, assigns, and vendors, to observe the foregoing covenants of this Article. 

  
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 Upon any violation of the foregoing covenants, Landlord shall be entitled to exercise all
remedies available to a landlord against a defaulting tenant, including but not limited to those set forth in Article 19 above. Without limiting the generality of the foregoing, Tenant expressly agrees that upon any such violation Landlord may, at
its option, (i) immediately terminate this Lease or (ii) continue this Lease in effect until compliance by Tenant with its clean-up and removal covenant notwithstanding any earlier expiration date of the Term of this Lease. No action by
Landlord hereunder shall impair the obligations of Tenant pursuant to this Article. 
 Landlord covenants and agrees that it shall not cause
or permit any Hazardous Material to be brought upon, kept, or used in or about the Premises or the Building by Landlord or its agents, employees or contractors in violation of applicable Law. Landlord shall be responsible for removing any Hazardous
Material brought upon, kept, or used in or about the Premises or the Building by Landlord or its agents, employees or contractors in violation of applicable Law, at no additional cost to Tenant. To Landlord’s actual knowledge, as of the date of
this Lease, there are no Hazardous Materials in the Premises in violation of applicable Laws. 
 As used in this subsection,
“Hazardous Materials” is used in its broadest sense and shall include any petroleum based products, pesticides, paints and solvents, polychlorinated biphenyl, lead, cyanide, DDT, acids, ammonium compounds and other chemical
products and any substance or material defined or designated as hazardous or toxic, or other similar term; by any federal, state or local environmental statute, regulation, or ordinance affecting the Premises or Building presently in effect or that
may be promulgated in the future, as such statutes, regulations and ordinances may be amended from time to time, including but not limited to the following statutes: Resource Conservation and Recovery Act of 1976, 42 U.S.C. §6901 et
seq.; Comprehensive Environmental Response, Compensation, and Liability Act of 1980, 42 U.S.C. §9601 et seq.; Clean Air Act, 42 U.S.C. §§7401-7626; Water Pollution Control Act (Clean Water Act of 1977), 33 U.S.C.
§1251 et seq.; Insecticide, Fungicide, and Rodenticide Act (Pesticide Act of 1987), 7 U.S.C. §135 et seq.; Toxic Substances Control Act, 15 U.S.C. §2601 et seq.; Safe Drinking Water Act, 42
U.S.C. §300(f) et seq.; National Environmental Policy Act (NEPA) 42 U.S.C. §4321 et seq.; Refuse Act of 1899, 33 U.S.C. §407 et seq. Tenant acknowledges that incorporation of any material
containing asbestos into the Premises is absolutely prohibited. Tenant agrees, represents and warrants that it shall not incorporate or permit or suffer to be incorporated any material containing asbestos into the Premises. 

31. Miscellaneous. 
 A.
Governing Law; Jurisdiction and Venue; Severability; Paragraph Headings. This Lease and the rights and obligations of the parties shall be interpreted, construed and enforced in accordance with the Laws of the state in which the Property
is located. All obligations under this Lease are performable in the county or other jurisdiction where the Property is located, which shall be venue for all legal actions. If any term or provision of this Lease shall be invalid or unenforceable,
then such term or provision shall be automatically reformed to the extent necessary to render such term or provision enforceable, without the necessity of execution of any amendment or new document. The remainder of this Lease shall not be affected,
and each remaining and reformed provision of this Lease shall be valid and enforced to the fullest extent permitted by Law. The headings and titles to the Articles and Sections of this Lease are for convenience only and shall have no effect on the
interpretation of any part of this Lease. The words “include”, “including” and similar words will not be construed restrictively to limit or exclude other items not listed. 

  
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 B. Recording. Tenant shall not record this Lease or any memorandum without
Landlord’s prior written consent. 
 C. Force Majeure. Whenever a period of time is prescribed for the taking of an
action by Landlord or Tenant, the period of time for the performance of such action shall be extended by the number of days that the performance is actually delayed due to strikes, acts of God, shortages of labor or materials, war, terrorist attacks
(including bio-chemical attacks), civil disturbances and other causes beyond the reasonable control of the performing party (“Force Majeure”). However, events of Force Majeure shall not extend any period of time for the
payment of Rent or other sums payable by either party or any period of time for the written exercise of an option or right by either party. 

D. Transferability; Release of Landlord. Landlord shall have the right to transfer and assign, in whole or in part, all of its
rights and obligations under this Lease and in the Building and/or Property, and upon such transfer Landlord shall be released from any further obligations hereunder, and Tenant agrees to look solely to the successor in interest of Landlord for the
performance of such obligations provided such successor in interest assumes in writing all obligations of Landlord hereunder from and after the date of such transfer. 

E. Brokers. Landlord and Tenant each represent that it has dealt directly with and only with Stream Realty Partners —
Austin, L.P., representing Landlord, and Skyles Bayne, representing Tenant (whose commissions shall be paid by Landlord pursuant to separate written agreements) in connection with this Lease. TENANT AND
LANDLORD SHALL EACH INDEMNIFY THE OTHER AGAINST ALL COSTS, EXPENSES, ATTORNEYS’
FEES, LIENS AND OTHER LIABILITY FOR COMMISSIONS OR OTHER COMPENSATION CLAIMED
BY ANY BROKER OR AGENT CLAIMING THE SAME BY, THROUGH OR UNDER
THE INDEMNIFYING PARTY, OTHER THAN THE BROKERS SPECIFICALLY IDENTIFIED
ABOVE. 
 F. Authority; Joint and Several Liability. Landlord covenants, wan-ants and
represents that each individual executing, attesting and/or delivering this Lease on behalf of Landlord is authorized to do so on behalf of Landlord, this Lease is binding upon and enforceable against Landlord, and Landlord is duly organized and
legally existing in the state of its organization and is qualified to do business in the state in which the Premises are located. Similarly, Tenant covenants, wan-ants and represents that each individual executing, attesting and/or delivering this
Lease on behalf of Tenant is authorized to do so on behalf of Tenant, this Lease is binding upon and enforceable against Tenant; and Tenant is duly organized and legally existing in the state of its organization and is qualified to do business in
the state in which the Premises are located. If there is more than one Tenant, or if Tenant is comprised of more than one party or entity, the obligations imposed upon Tenant shall be joint and several obligations of all the parties and entities.
Notices, payments and agreements given or made by, with or to any one person or entity shall be deemed to have been given or made by, with and to all of them. 

G. Time is of the Essence; Relationship; Successors and Assigns. Time is of the essence with respect to Tenant’s
performance of its obligations and the exercise of any expansion, renewal or extension rights or other options granted to Tenant. This Lease shall create only the relationship of landlord and tenant between the parties, and not a partnership, joint
venture or any other relationship. This Lease and the covenants and conditions in this Lease shall inure only to the benefit of and be binding only upon Landlord and Tenant and their permitted successors and assigns. 

H. Survival of Obligations. The expiration of the Term, whether by lapse of time or otherwise, shall not relieve either party of
any obligations which accrued prior to or which may continue to accrue after the expiration or early termination of this Lease. Without limiting the scope of the prior sentence, it is agreed that the obligations under Articles 4, 6,
8, 12, 13, 19, 24, 29 and 30 shall survive the expiration or early termination of this Lease. 

  
 31 

 I. Binding Effect. Landlord has delivered a copy of this Lease to Tenant for
Tenant’s review only, and the delivery of it does not constitute an offer to Tenant or an option. This Lease shall not be effective against Landlord until an original copy of this Lease has been signed by Landlord and delivered to Tenant. 

J. Full Agreement; Amendments. This Lease contains the parties’ entire agreement regarding the subject matter hereof. All
understandings, discussions, and agreements previously made between the parties, written or oral, are superseded by this Lease, and neither party is relying upon any warranty, statement or representation not contained in this Lease. This Lease may
be modified only by a written agreement signed by Landlord and Tenant. The exhibits and riders attached hereto are incorporated herein and made a part of this Lease for all purposes. 

K. Tax Waiver. TENANT HEREBY WAIVES ALL RIGHTS TO PROTEST THE APPRAISED VALUE OF THE PROPERTY OR TO APPEAL THE SAME AND ALL
RIGHTS TO RECEIVE NOTICES OF REAPPRAISALS AS SET FORTH IN SECTIONS 41.413 AND 42.015 OF THE TEXAS TAX CODE. 
 L. Method of
Calculation. Landlord and Tenant agree that each provision of the Lease for determining charges, amounts and additional Rent payments by Tenant (including without limitation, Article 4 of this Lease) is commercially reasonable, and as
to each such charge or amount, constitutes a “method by which the charge is to be computed” for purposes of Section 93.012 (Assessment of Charges) of the Texas Property Code, as such section now exists or as it may be hereafter
amended or succeeded. 
 M. WAIVER OF CONSUMER RIGHTS. TENANT HEREBY WAIVES ALL ITS RIGHTS UNDER THE TEXAS DECEPTIVE TRADE
PRACTICES - CONSUMER PROTECTION ACT, SECTION 17.41 ET. SEQ. OF THE TEXAS BUSINESS AND COMMERCE CODE (THE “DTPA”), A LAW THAT GIVES CONSUMERS SPECIAL RIGHTS AND PROTECTIONS. AFTER CONSULTATION WITH AN ATTORNEY OF TENANT’S OWN
SELECTION, TENANT VOLUNTARILY CONSENTS TO THIS WAIVER. 
 N. ERISA. Tenant represents to Landlord that either
(a) Tenant is not an “employee benefit plan” within the meaning of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”), that is subject to Title I of ERISA, a “plan” within the
meaning of Section 4975 of the Internal Revenue Code of 1986, as amended (the “Code”), or an entity that is deemed to hold “plan assets” within the meaning of 29 C.F.R. Section 2510.3-101 of any such
employee benefit plan or (b) the entering into this Lease will not result in a non-exempt prohibited transaction under Section 406 of ERISA or Section 4975 of the Code. 

O. Anti-Terrorism Representations. Tenant is not, and shall not during the Term of the Lease become, a person or entity with
whom Landlord is restricted from doing business under the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001, H. R. 3162, Public Law 107-56 (commonly known as the “USA
Patriot Act”) and Executive Order Number 13224 on Terrorism Financing, effective September 24, 2001 and regulations promulgated pursuant thereto (collectively, “Anti-Terrorism Laws”), including without
limitation persons and entities named on the Office of Foreign Asset Control Specially Designated Nationals and Blocked Persons List (collectively, “Prohibited Persons”). To the best of its knowledge, Tenant is not currently
engaged in any transactions or dealings, or otherwise associated with, any Prohibited Persons in connection with the use or occupancy of the Premises, the Building or the Property. Tenant will not, during the Term of this Lease, engage in any
transactions or dealings, or be otherwise associated with, any Prohibited Persons in connection with the use or occupancy of the Premises, the Building or the Property. Tenant’s breach of any representation or covenant set forth in this Section
shall constitute a breach of this Lease by Tenant, entitling Landlord to any and all remedies hereunder, or at law or in equity. 

  
 32 

 P. Waiver of Trial by Jury. TENANT AND LANDLORD HEREBY KNOWINGLY AND VOLUNTARILY WAIVE
TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTER CLAIM, BROUGHT BY ONE PARTY AGAINST THE OTHER OR ANY MATTER WHATSOEVER ARISING OUT OF OR IN ANY WAY CONNECTED WITH THIS LEASE, THE RELATIONSHIP OF LANDLORD AND TENANT CREATED HEREBY, THE
TENANT’S USE OR OCCUPANCY OF THE PREMISES AND/OR ANY CLAIM FOR INJURY OR DAMAGE. THE PARTIES ARE HEREBY AUTHORIZED TO FILE A COPY OF THIS PARAGRAPH IN ANY PROCEEDING AS CONCLUSIVE EVIDENCE OF THE FOREGOING WAIVER. 

Q. Lease Not a Construction Contract. Landlord and Tenant acknowledge and agree that this Lease, including all exhibits a part
hereof, is not a construction contract or an agreement collateral to or affecting a construction contract. 
 R. Tenant’s
Signage. Landlord shall provide, at no additional cost to Tenant, a Building standard suite identification sign adjacent to the entry to the Premises. In addition, Landlord shall add, at Landlord’s sole cost and expense, Tenant’s
name to the Building directory located in the lobby of the Building within ten (10) days following the Commencement Date. 

  
 33 

 Landlord and Tenant have executed this Lease as of the Effective Date specified below
Landlord’s signature. 
  

									
	LANDLORD:
	
	BARTON OAKS OFFICE CENTER, LLC, a Delaware limited liability company
		
	By:		MIG Real Estate, LLC, a Delaware limited liability company, its Manager
			
			By:		 MIG Real Estate Services, LLC, a Delaware limited liability company

Its Agent

 
							
			
			By:		 /s/ Dave Patty

			Name:		Dave Patty
			Title:		Authorized Officer

 
							
		
			Effective Date: November 24, 2014

  

			
	TENANT:
	
	AEGLEA DEVELOPMENT COMPANY, INC., a Delaware corporation
		
	By:		 /s/ David G. Lowe

	Name:		David G. Lowe
	Title:		President & CEO

  
 34 

 EXHIBIT A-1 

OUTLINE AND LOCATION OF PREMISES 
  

 
 

 

  
 A-1 

 EXHIBIT A-2 

LEGAL DESCRIPTION OF PROPERTY 
 Building
“A”, Unit No. One (!), BARTON OAKS PLAZA CONDOMINIUM, a condominium project in Travis County, Texas, according to the Second Amended and Restated Declaration of Condominium for Barton Oaks Plaza Condominium and amendments thereto, recorded
in Volume 12236, Page 567, of the Real Property Records of Travis County, Texas, together with an exclusive right to the limited common elements (as defined in the Declaration) to Building “A”, including a 3 level parking garage, as
indicated on the Plat (Exhibit “C” of the Declaration) and an undivided interest in and to the general common elements appurtenant thereto. 

  
 A-2 

 EXHIBIT B 

RULES AND REGULATIONS 
 1. Sidewalks,
halls, passageways, exits, entrances, elevators, escalators, stairways, and other common areas shall not be obstructed by Tenant or used by Tenant for any purpose other than for ingress to and egress from the Premises. Landlord shall in all cases
retain the right to control and prevent access thereto by all persons whose presence, in the judgment of the Landlord, shall be prejudicial to the safety, character, reputation or interests of the Building, including its tenants and occupants.
Nothing shall be swept or thrown into the corridors, halls, elevators or stairways. 
 2. No sign, placard, picture, name, advertisement or notice (a
“Sign”) visible from the exterior of the Premises shall be inscribed, painted, affixed, installed or displayed by Tenant without the prior written consent of Landlord. Absent any such consent, Landlord shall have the right to remove any
Sign without notice to and at the expense of Tenant. Any such consent shall be deemed to relate to only the particular Sign so consented to by Landlord and shall not be construed as dispensing with the necessity of obtaining the prior written
consent of Landlord with respect to any other Sign. All approved Signs or lettering on doors and walls shall be inscribed, painted, affixed, installed, printed or otherwise displayed, at the expense of Tenant, by a person approved by Landlord and in
a manner or style acceptable to Landlord. 
 3. No curtains, draperies, blinds, shutters, shades, screens or other coverings, awnings, hangings or
decorations shall be installed or used in connection with any window or door of the Premises without the prior written consent of Landlord, except for normal and customary interior decorations to the Premises not visible from the exterior of the
Building. In any event, any such items shall be installed so as to face the interior surface of the standard window treatment established by Landlord and shall in no way be visible from the exterior of the Building. No articles shall be placed or
kept on the windowsills or any terraces so as to be visible from the exterior of the Building. No articles shall be placed against glass partitions or doors which might appear unsightly from the outside the Premises. No sashes, sash doors,
skylights, windows or doors that reflect or admit light or air into the halls, passageways or other public places in the Building shall be covered or obstructed by Tenant without the prior written consent of Landlord. 

4. Tenant shall not employ or permit any person(s) other than the janitorial contractor of the Landlord to clean the Premises without the prior written
consent of Landlord. In the event of any permitted person being employed by Tenant to do janitorial work, while in the Building and outside of the Premises such person(s) shall be subject to the control and direction of the Building’s
management office (not as an agent or servant of Landlord); however, Tenant shall in all cases be responsible for the acts of such person(s). 
 5. Tenant
and its employees, upon daily departure, shall cause (a) the doors of the Premises to be securely locked, and (b) to the extent practical shut off all faucets, valves and other control apparatuses to water and other resources, so as to
prevent waste or damage. With the exception of permitting ingress and egress to the Building, Tenant shall keep doors(s) to the Building’s corridors on multi-tenant floors of the Building closed at all times. 

6. Tenant shall not waste electricity, water, heating, air-conditioning or any other resources and shall cooperate fully with Landlord to assure the most
effective utilization of such Building resources. Tenant shall not attempt to adjust any Building resource controls other than any thermostats specifically installed for Tenant’s use. No heating, air-conditioning unit or other similar apparatus
shall be installed or used by Tenant without the prior written consent of Landlord. 

  
 B-1 

 7. Tenant shall not alter any lock or access device, nor shall Tenant install any new or additional lock, access
device or bolt on any door of the Premises without the prior written consent of Landlord. In the event of any permitted installation, Tenant shall in each case furnish Landlord with a key for any such lock or device. 

8. Landlord shall furnish Tenant, at no cost to Tenant, one (I) key to the Premises for each employee who will work primarily at the Premises as of the
Commencement Date. Tenant shall pay a reasonable charge for any additional keys furnished by Landlord. Any card-keys issued by Landlord may upon such issuance require payment of a refundable deposit in an amount reasonably determined from time to
time by Landlord. Tenant shall not make or have made copies of any keys or card-keys furnished by Landlord. Tenant shall, upon the expiration or sooner termination of its tenancy, deliver to Landlord all of such keys and card-keys, together with any
of the keys relating to the Premises including, but not limited to, all keys to any vaults or safes which remain on the Premises. In the event of the loss of any keys furnished by Landlord to Tenant, Tenant shall pay Landlord (a) the cost
thereof (less any deposit paid by Tenant) or (b) the cost of changing the subject lock(s) or access device(s) if Landlord deems it necessary to make such change. 

9. The toilet rooms, toilets, urinals, washbowls, plumbing fixtures and any other Building apparatus shall not be used for any purpose other than that for
which they were constructed; and no foreign substance of any kind shall be thrown therein. Any loss, cost or expense relating to any breakage, stoppage or damage resulting from any violation of this rule by Tenant shall be borne by Tenant. 

10. Tenant shall not permit any cooking on the Premises (except that private, non commercial use by Tenant and its employees of Underwriters’
Laboratory-approved equipment for the preparation of coffee, tea, hot chocolate and similar beverages, and for the heating of foods, shall be permitted; provided that such equipment is used in accordance with all applicable federal, state and city
laws, codes, ordinances, rules and regulations). The Premises shall not be used for lodging or sleeping purposes. If the Premises becomes infested with vermin or pests, Tenant, at its sole cost and expense, shall have such pests exterminated by
Landlord approved exterminators. 
 11. All tenants will refer any contractors, contractor’s representatives and installation technicians rendering any
services to them to Landlord for Landlord’s supervision and approval prior to commencement of any work. 
 12. Tenant shall not install any radio or
television antenna, loudspeaker or other device on the roof or exterior of the Building. Tenant shall not interfere with any radio or television broadcast or reception from within the Building. 

13. The freight elevator shall be available for use by Tenant, subject to reasonable scheduling by Landlord. No furniture, freight, equipment, materials,
supplies, packages, merchandise or other property shall be received in the Building or carried up or down the elevators, except between such hours and in such elevators designated by Landlord. Any deliveries, removals or relocations of large, bulky
or voluminous items, such as furniture, office machinery and equipment, etc., can only be made after obtaining approval from the Landlord, which approval shall not be unreasonably withheld or delayed. Tenant shall indemnify and hold Landlord
harmless against claims of damage to articles moved and injury to persons engaged in such movement on behalf of Tenant, including without limitation, damages and injury to equipment, property and personnel of Landlord resulting from Tenant’s or
its agent’s, contractor’s or employee’s acts in connection with such delivery, removal or relocation. All damages done to the Building by the installation or removal of any of Tenant’s property shall be repaired at the expense of
Tenant. 

  
 B-2 

 14. Tenant shall not place a load upon any floor of the Premises which exceeds the load per square foot the floor
was designed to carry, or any load allowed by law. Landlord shall have the right to prescribe the weight, size and position of safes, any library or other shelving, furniture or other heavy equipment brought into the Building, and Tenant shall bear
the reasonable fees of any structural engineer hired by Landlord in connection therewith. Safes or other heavy objects shall, if considered necessary to Landlord, stand on wood strips of such thickness as determined by Landlord to be necessary to
properly distribute the weight thereof. Landlord shall not be responsible for loss of or damage to any such safes or other heavy objects for any cause; all damages done to the Building by moving or maintaining of any such items shall be repaired at
the expense of Tenant. 
 15. No machinery other than the kind considered usual and standard for general office use shall be operated by any tenant in its
leased area without the prior written consent of Landlord. Business machines or mechanical equipment of Tenant, which causes noise or vibration that may be transmitted to the structure of the Building or any space therein to such a degree
objectionable to Landlord or any other tenants or occupants of the Building, shall be placed and maintained by Tenant, at Tenant’s expense, on vibration eliminators or other devices sufficient to eliminate such noise or vibration. Tenant shall
bear the reasonable fees of any acoustical or structural engineer hired by Landlord in connection therewith. 
 16. Tenant shall not mark, drive nails or
screws, or drill into the partitions, ceilings or floors of the Premises or in any way deface the Premises except for normal and customary interior decorations. 

17. Tenant shall not install, maintain or operate on the Premises any vending machine without the prior written consent of Landlord. 

18. No animals (other than those assisting the handicapped), including reptiles, birds, fish (or aquariums), or other non-human, non-plant living things or
organic Christmas decor of any kind shall be allowed in the Building. 
 19. There shall not be used in the Building any hand trucks, except those equipped
with rubber tires and side guards, or any other material handling equipment, except as approved in advance in writing by Landlord. No scooters, roller skates, roller blades, bicycles, and no other vehicles of any kind shall be brought into and
operated within the Building. Bicycles and vehicles may only be parked in areas designated for such purpose. 
 20. Tenant shall store all of its trash and
garbage within the interior of the Premises. No materials shall be placed in the Building’s trash boxes or receptacles if such material is of such a nature that it may not be disposed of in the ordinary and customary manner, or if such an act
would violate any law or ordinance governing such removal and disposal. 
 21. Canvassing, soliciting, distributing of handbills or any other written
material, and peddling in the Building are prohibited; Tenant shall cooperate to prevent such activity. Tenant shall not engage in office-to-office solicitation of business from other tenants or occupants of the Building. 

22. Landlord reserves the right to exclude or to expel from the Building any person who, in Landlord’s judgment, is intoxicated or under the influence of
liquor or drugs, or who is in violation of any of these Rules and Regulations. 
 23. Tenant shall comply with all safety, fire protection and evacuation
procedures and regulations established by Landlord or any governmental agency. No firearms or weapons of any kind are allowed within the Premises or the Building. 

  
 B-3 

 24. No tenant shall invite to its premises, or permit the visit of, persons in such numbers or under such
conditions to interfere with the use and enjoyment of any of the plazas, entrances, corridors, escalators, elevators, and other facilities of the Building by other tenants. 

25. Landlord will not be responsible for lost or stolen personal property, money or jewelry from any tenant’s Premises or public or common areas
regardless of whether such loss occurs when the area is locked against entry or not, except as may be otherwise set forth in the Lease. Tenant assumes any and all responsibility for protecting the Premises from theft, robbery and pilferage by taking
necessary steps including, but not limited to, keeping doors locked and other means of entry to the Premises closed. 
 26. Any additional or special
requirements of Tenant shall be attended to only upon application to the office of the Building by an authorized individual. Employees of Landlord shall not perform any work or do anything outside of the regular duties unless under special
instructions from Landlord. No such employees shall admit any person (Tenant or otherwise) to any office without specific instructions from Landlord. 
 27.
Landlord may waive any of these Rules and Regulations for the benefit of any particular tenant or occupant of the Building in any particular instance; however, no such waiver by Landlord shall be construed as a waiver of these Rules and Regulations
with respect to any other tenant or occupant thereof. Any revised rules and regulations, when made and written notice thereof is given to a tenant, shall be binding upon it in like manner as if originally herein prescribed. 

These Rules and Regulations including the addendum attached hereto are provided as a general guideline. Please refer to your Lease Agreement for info1mation
specific to your tenancy. 

  
 B-4 

 ADDENDUM TO BUILDING RULES AND REGULATIONS 

THIS ADDENDUM is attached to and made part of the Rules and Regulations for the Building known as Barton Oaks Plaza One, Austin, Texas. 

1. Tenant shall provide Landlord with a list of all personnel authorized to enter the Building after hours (6:00 p.m. to 8:00 a.m., Monday through Friday and
24 hours a day on weekends and holidays) upon Landlord’s written request. 
 2. Anyone entering or leaving the Building after hours must show proper
identification if requested. 
 3. Any air conditioning/heating required during the periods of 6:00 p.m. to 8:00 a.m. Monday through Friday, 1:00 p.m. to
midnight Saturday (unless otherwise stipulated in the Lease), and 24 hours a day Sundays and holidays, shall be accessed by Tenant using the Building’s computerized system for such overtime services. Tenant shall be charged the prevailing
hourly rate (with a two hour minimum charge) for such additional heating or air conditioning in accordance with the terms of the Lease. 
 4. Tenant
representative must be present on-site and oversee any furniture or equipment being removed from the Building. On-site security will be able to assist but will not be responsible for any negligence by Tenant. 

5. Use of the elevator for furniture is limited to after hours on weekdays and on weekends and must be coordinated with the Property Management and Building
Security to give better assistance. 
 6. Names to be placed on or removed from the Directory in the lobby of the Building should be furnished to the
Property Management Office in writing on Tenant’s letterhead. 
 7. Tenant shall not use the Premises or permit the Premises to be used for
photographic or multigraph reproductions, except in connection with its own business. 
 8. Tenant shall place solid pads under all rolling chairs such as
may be used at desks or tables. Any damages caused to carpet by not having it shall be repaired or replaced at the expense of the Tenant. 
 9. Tenant shall
have Building standard signage on the directory in the lobby and door signage at the front door of the Premises at no additional cost to Tenant. 

  
 B-5 

 EXHIBIT C 

COMMENCEMENT LETTER 
  

	Re:	Office Lease dated as of                     , 20     (the “Lease”) between
BARTON OAKS OFFICE CENTER, LLC, a Delaware limited liability company (“Landlord”) and AEGLEA DEVELOPMENT COMPANY, INC., a Delaware corporation (“Tenant”) for the Premises, the Rentable Square Footage
of which is 5,771 located on the second (2nd) floor of the Building. Unless otherwise specified, all capitalized terms used herein shall have the same meanings as in the Lease. 

Landlord and Tenant agree that: 
  

	1.	Landlord has fully completed all Landlord Work required under the terms of the Lease. 

  

	2.	Tenant has accepted possession of the Premises. The Premises are usable by Tenant as intended; Landlord has no further obligation to perform any Landlord Work or other construction, and Tenant acknowledges that both the
Building and the Premises are satisfactory in all respects. 

  

	3.	The Commencement Date of the Lease is             , 20    . 

 

	4.	The Expiration Date of the Lease is the last day of             , 20    . 

 

	5.	Tenant’s Address at the Premises after the Commencement Date is: 

 Aeglea Development
Company, Inc. 
 Barton Oaks Plaza One, Suite 250 

901 MoPac Expressway South 

Austin, Texas 78746 
 Attention:
                     
 All other terms and conditions
of the Lease are ratified and acknowledged to be unchanged. 
 [Signature page follows] 

  
 C-1 

 EXECUTED as of             , 2014 

 

							
	LANDLORD:
	
	BARTON OAKS OFFICE CENTER, LLC, a Delaware limited liability company
		
	By:		MIG Real Estate, LLC, a Delaware limited liability company, its Manager
			
			By:		MIG Real Estate Services, LLC, a Delaware limited liability company Its Agent
				
					By:		  

					Name:		  

					Title:		  

	
	TENANT:
	
	AEGLEA DEVELOPMENT COMPANY, INC., a Delaware corporation
		
	By:		  

	Name:		  

	Title:		  

  
 C-2 

 EXHIBIT D 

WORK LETTER 
 This Work
Letter is attached as an Exhibit to an Office Lease (the “Lease”) between BARTON OAKS OFFICE CENTER, LLC, a Delaware limited liability company, as Landlord, and AEGLEA DEVELOPMENT COMPANY, INC., a Delaware corporation, as
Tenant. Unless otherwise specified, all capitalized terms used in this Work Letter shall have the same meanings as in the Lease. In the event of any conflict between the Lease and this Work Letter, the latter shall control. 

1. Approved Construction Documents. 

(a) Tenant’s Information. Within 10 days after the Effective Date of this Lease, Tenant shall submit to Landlord (i) the name
of a representative of Tenant who has been designated as the person responsible for receiving all information from and delivering all information to Landlord relating to the construction of the Landlord Work (as defined below), and (ii) all
information necessary for the preparation of complete, detailed architectural, mechanical, electrical and plumbing drawings and specifications for construction of the Landlord Work in the Premises, including Tenant’s partition and furniture
layout, reflected ceiling, telephone and electrical outlets and equipment rooms, initial provider(s) of telecommunications services, doors (including hardware and keying schedule), glass partitions, windows, critical dimensions, imposed loads on
structure, millwork, finish schedules, security devices, if any, which Tenant desires or Landlord requires to have integrated with other Building safety systems, and HVAC and electrical requirements (including Tenant’s connected electrical
loads and the National Electrical Code (NFPA-70) Design Load Calculations), together with all supporting information and delivery schedules (“Tenant’s Information”). 

(b) Construction Documents. Following Landlord’s execution of the Lease and receipt of Tenant’s Information, Landlord’s
designated architectural/engineering firm shall prepare and submit to Tenant all finished and detailed architectural drawings and specifications, including mechanical, electrical and plumbing drawings (the “Construction
Documents”). In addition, Landlord shall advise Tenant of the number of days of Tenant Delay (as defined below) attributable to extraordinary requirements (if any) contained in Tenant’s Information. Landlord (or its designated
representative) reserves the right to designate the location(s) of all of Tenant’s mechanical, electrical or other equipment and the manner in which such equipment will be connected to Building systems. 

(c) Approved Construction Documents. Within 7 Business Days after receipt, Tenant shall (i) approve and return the Construction
Documents to Landlord, or (ii) provide Landlord Tenant’s written requested changes to the Construction Documents, in which event Landlord shall have the Construction Documents revised (as Landlord deems appropriate) and resubmitted to
Tenant for approval within 7 Business Days after receipt. If Tenant fails to request changes within such 7 Business Day period, Tenant shall be deemed to have approved the Construction Documents. Upon Tenant’s approval, the Construction
Documents shall become the “Approved Construction Documents.” By granting approval of the Construction Documents (whether such approval is expressly granted or deemed given as provided above), Tenant shall be deemed to have
confirmed by means of calculations or metering that the available capacity of the Building electrical system will support Tenant’s electrical requirements. 

2. Pricing and Bids. Following receipt of the Approved Construction Documents, Landlord will promptly price the construction of the Landlord
Work with approved general contractors in accordance with the Approved Construction Documents and furnish written price estimates to Tenant. Upon receipt, Tenant shall promptly review such estimates and complete negotiations with Landlord for any
changes or adjustments thereto. Within 7 Business Days after such receipt, Tenant shall return the estimates with 

  
 D-1 

 
written approval to Landlord. If Tenant fails to give its approval within such 7 Business Day period, the estimates will be deemed approved by Tenant and Landlord will be permitted to make a
selection from such approved estimates. 
 3. Landlord’s Contributions. Landlord will provide a construction allowance not to exceed
$69,252.00, such amount calculated at the rate of Twelve and Noll 00 Dollars ($12.00) per Rentable Square Foot of the Premises (the “Construction Allowance”), toward the cost of constructing the Landlord Work. Payments shall be made
directly to Landlord’s contractor performing the Landlord Work. The cost of (a) all space planning, design, consulting or review services and construction drawings, (b) extension of electrical wiring from Landlord’s designated
location(s) to the Premises, (c) purchasing and installing all Building equipment for the Premises (including any submeters and other above Building standard electrical equipment approved by Landlord), (d) required metering, re-circuiting
or re-wiring for metering, equipment rental, engineering design services, consulting services, studies, construction services, cost of billing and collections, (e) materials and labor, and (f) an asbestos survey of the Premises if required
by applicable Law shall all be included in the cost of the Landlord Work and may be paid out of the Construction Allowance, to the extent sufficient funds are available for such purpose. In addition, Landlord will provide a test fit allowance of up
to $577.10 (the “Test Fit Allowance”) toward the cost incurred by Tenant for the preparation of floor plans for the Premises. Landlord will pay the preparer of such floor plan for such costs (up to the amount of the Test Fit
Allowance) within thirty (30) days after Landlord’s receipt of invoices therefor. Tenant acknowledges that an asbestos survey may be required by applicable Law and that the time required for such asbestos surveys should be incorporated in
Tenant’s construction planning, if applicable. If the actual cost of the Landlord Work is less than the Construction Allowance, up to $11,542.00 of such remaining amount (calculated at a rate of Two and No/I 00 Dollars ($2.00) per Rentable
Square Foot of the Premises (the “Permitted Additional Cost Allowance”) may be used for the following costs: (i) actual out-of-pocket move related expenses paid by Tenant to unrelated third parties, and
(ii) purchase and installation of telephone and data cabling (such costs, “Permitted Additional Costs”). Following the Commencement Date, Landlord will reimburse Tenant for the Permitted Additional Costs (to the extent
of any remaining Permitted Additional Cost Allowance) within thirty (30) days after Landlord’s receipt of invoices therefor. The Construction Allowance, including any Permitted Additional Cost Allowance, made available to Tenant under this
Work Letter must be utilized for its intended purpose within six (6) months of the Commencement Date or be forfeited with no further obligation on the part of Landlord. 

4. Construction. 
 (a) General
Terms. Subject to the terms of this Work Letter, Landlord agrees to cause leasehold improvements to be constructed in the Premises (the “Landlord Work”) in a good and workmanlike manner in accordance with the Approved
Construction Documents and all applicable Laws. In the event of any defects in the Landlord Work reported in writing to Landlord within I 80 days after the Commencement Date, Landlord shall remedy the same (or cause such defect to be remedied) as
soon as reasonably practicable. In the event of such errors, omissions or defects, and upon Tenant’s written request, Landlord will use commercially reasonable efforts to cooperate with Tenant in enforcing any applicable warranties. In
addition, Landlord’s approval of the Construction Documents or the Landlord Work shall not be interpreted to waive or otherwise modify the terms and provisions of the Lease. The terms and provisions contained in this Work Letter shall survive
the completion of the Landlord Work. Tenant acknowledges that Tenant’s Information and the Approved Construction Documents must comply with (i) the definitions used by Landlord for the electrical terms used in this Work Letter,
(ii) the electrical and HVAC design capacities of the Building, (iii) Landlord’s policies concerning communications and fire alarm services, and (iv) Landlord’s policies concerning Tenant’s electrical design parameters,
including harmonic distortion. Upon Tenant’s request, Landlord will provide Tenant a written statement outlining items (i) through (iv) above. 

  
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 (b) Substantial Completion. The Landlord Work shall be deemed to be
“Substantially Complete” on the date that all Landlord Work (other than any details of construction, mechanical adjustment or any other similar matter, the noncompletion of which does not materially interfere with
Tenant’s use or occupancy of the Premises) has been performed and a certificate of occupancy has been issued for the Premises Time is of the essence in connection with the obligations of Landlord and Tenant under this Work Letter. Landlord
shall not be liable or responsible for any claims incurred (or alleged) by Tenant due to any delay in achieving Substantial Completion for any reason. Tenant’s sole and exclusive remedy for any delay in achieving Substantial Completion by the
Estimated Commencement Date for any reason other than Tenant Delay (defined below) shall be the resulting postponement (if any) of the Commencement Date. “Tenant Delay” means any act or omission of Tenant or its agents, employees, vendors
or contractors that actually delays the Substantial Completion of the Landlord Work, including: (i) Tenant’s failure to furnish information or approvals within any time period specified in this Lease, including the failure to prepare or
approve preliminary or final plans by any applicable due date; (ii) Tenant’s selection of non-Building standard equipment or materials (provided Landlord gives written notice to Tenant at the time of Tenant’s selection of such
non-Building standard equipment or materials that such equipment or materials will delay Substantial Completion of the Landlord Work); (iii) changes requested or made by Tenant to the Approved Construction Documents; or (iv) performance of
work in the Premises by Tenant or Tenant’s contractor(s) during the performance of the Landlord Work. 
 5. Costs. 

(a) Change Orders and Cost Overruns. Landlord’s approval is required in advance of all changes to, and deviations from, the
Approved Construction Documents (each, a “Change Order”), including any (i) omission, removal, alteration or other modification of any portion of the Landlord Work, (ii) additional architectural or engineering
services, (iii) changes to materials, whether building standard materials, specially ordered materials, or specially fabricated materials, or (iv) cancellation or modification of supply or fabrication orders. Except as otherwise expressly
provided in this Work Letter, all costs of the Landlord Work in excess of the Construction Allowance including Change Orders requested by Tenant and approved by Landlord which increase the cost of the Landlord Work (collectively, “Cost
Overruns”) shall be paid by Tenant to Landlord within 10 business days of receipt of Landlord’s written demand, together with documentation supporting such Cost Overrun. In addition, at Landlord’s election, Landlord may
require Tenant to prepay any projected Cost Overruns within 10 business days of receipt of Landlord’s written demand, together with documentation supporting such Cost Overrun. Landlord may stop or decline to commence all or any portion of the
Landlord Work until such payment (or prepayment) of Cost Overruns is received. On or before the Commencement Date, and as a condition to Tenant’s right to take possession of the Premises, Tenant shall pay Landlord the entire amount of all Cost
Overruns, less any prepaid amounts. Tenant’s failure to pay, when due, any Cost Overruns or the cost of any Change Order shall constitute an event of default under the Lease if such failure continues for five (5) days following
Tenant’s receipt of Landlord’s written notice of such failure. 
 (b) Construction Management Fee. Within 10 days following
the date of invoice, Tenant shall, for supervision and administration of the construction and installation of the Landlord Work, pay Landlord a construction management fee equal to 5% of the aggregate contract price for the Landlord Work, which may
be paid from the unused portion of the Construction Allowance (if any). Landlord, at its option, may withhold such construction management fee from the Construction Allowance. Tenant’s failure to pay such construction management fee when due
shall constitute an event of default under the Lease. 
 6. Acceptance. Subject to Section 3.B of the Lease, by taking possession
of the Premises, Tenant agrees and acknowledges that (i) the Premises are usable by Tenant as intended; (ii) Landlord has no further obligation to perform any Landlord Work or other construction (except punchlist items, if any

  
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agreed upon by Landlord and Tenant in writing and latent defects in the Landlord Work reported in writing to Landlord within 180 days after the Commencement Date); and (iii) both the
Building and the Premises are satisfactory in all respects. 
 7. Applicability of Exhibit. This Exhibit shall not be deemed applicable to any
additional space added to the Premises at any time or from time to time, whether by any options under the Lease or otherwise, or to any portion of the original Premises or any additions to the Premises in the event of a renewal or extension of the
original Term of the Lease, whether by any options under the Lease or otherwise, unless expressly so provided in the Lease or any amendment or supplement to the Lease. 

  
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 EXHIBIT E 

PARKING AGREEMENT 
 This
Parking Agreement (the “Agreement”) is attached as an Exhibit to an Office Lease (the “Lease”) between BARTON OAKS OFFICE CENTER, LLC, a Delaware limited liability company, as Landlord, and AEGLEA
DEVELOPMENT COMPANY, INC., a Delaware corporation, as Tenant. Unless otherwise specified, all capitalized terms used in this Agreement shall have the same meanings as in the Lease. 

1. As of the Commencement Date of the Lease, Landlord shall provide to Tenant on an unreserved and non-exclusive basis the number of parking spaces
equal to the ratio of 3.3 parking spaces per 1,000 Rentable Square Foot of the Premises in parking facilities which Landlord provides for the use of tenants and occupants of the Building (the “Parking Facilities”). 

2. The rent for such parking spaces shall be the rate from time to time designated by Landlord as standard for the Building provided that during the
initial Term of the Lease, the monthly rate for each unreserved parking space shall be $0.00. 
 3. Tenant shall at all times comply with all Laws
respecting the use of the Parking Facilities. Landlord reserves the right to adopt, modify, and enforce reasonable rules and regulations governing the use of the Parking Facilities or the Property, from time to time, including any key-card, sticker,
or other identification or entrance systems and hours of operations, and Tenant shall comply with all such rules and regulations, provided such rules and regulations will not be enforced in a discriminatory manner against Tenant. Landlord may refuse
to permit any person who violates such rules and regulations to park in the Parking Facilities, and any violation of the rules and regulations shall subject the automobile in question to removal from the Parking Facilities. 

4. Unless specified to the contrary above, the parking spaces for the parking permits provided hereunder shall be provided on an unreserved,
“first-come, first-served” basis. Tenant acknowledges that Landlord has arranged or may arrange for the Parking Facilities to be operated by an independent contractor, un-affiliated with Landlord. In such event, Tenant acknowledges that
Landlord shall have no liability for claims arising through acts or omissions of such independent contractor. Landlord shall have no liability whatsoever for any damage to vehicles or any other items located in or about the Parking Facilities, and
in all events, Tenant agrees to seek recovery from its insurance carrier and to require Tenant’s employees to seek recovery from their respective insurance carriers for payment of any property damage sustained in connection with any use of the
Parking Facilities. Landlord reserves the right to assign specific parking spaces, and to reserve parking spaces for visitors, small cars, handicapped persons and for other tenants, guests of tenants or other parties, with assigned and/or reserved
spaces. Such reserved spaces may be relocated as determined by Landlord from time to time, and Tenant and persons designated by Tenant hereunder shall not park in any such assigned or reserved parking spaces. Landlord also reserves the right to
close all or any portion of the Parking Facilities, at its discretion or ifrequired by casualty, strike, condemnation, repair, alteration, act of God, Laws, or other reason beyond Landlord’s reasonable control. If Tenant’s use of any
parking permit is precluded for any reason, Tenant’s sole remedy for any period during which Tenant’s use of any parking permit is precluded shall be abatement of parking charges for such precluded permits. Tenant shall not assign its
rights under this Agreement, except in connection with a Permitted Transfer or a Transfer consented to by Landlord pursuant to Article 11 of the Lease. 

5. Tenant’s failure to comply with any provision of this Agreement shall constitute an event of default under the Lease if such failure continues
for thirty (30) days following Landlord’s written notice thereof to Tenant. In addition to any rights or remedies available to Landlord in the event of a default under the Lease, Landlord shall have the right to remove any offending
vehicles from the Parking Facilities at the car owner’s expense and terminate the right of any offending parker to use the Parking Facilities. 

  
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