Document:

EX-10.4

 Exhibit 10.4 
 FORM OF INDEMNIFICATION AGREEMENT 
 BLUEBIRD BIO, INC. 

 
  

Indemnification Agreement 
 This Indemnification Agreement (“Agreement”) is made as of [            ] by and between bluebird bio, Inc., a
Delaware corporation (the “Company”), and (“Indemnitee”). 
 RECITALS 

WHEREAS, the Company desires to attract and retain the services of highly qualified individuals, such as Indemnitee, to serve the
Company; 
 WHEREAS, in order to induce Indemnitee to provide or continue to provide services to the Company, the Company wishes
to provide for the indemnification of, and advancement of expenses to, Indemnitee to the maximum extent permitted by law; 

WHEREAS, the Bylaws (as the same may be amended, restated or otherwise modified from time to time, the “Bylaws”) of the
Company require indemnification of the officers and directors of the Company, and Indemnitee may also be entitled to indemnification pursuant to the General Corporation Law of the State of Delaware (the “DGCL”); 

WHEREAS, the Bylaws and the DGCL expressly provide that the indemnification provisions set forth therein are not exclusive, and thereby
contemplate that contracts may be entered into between the Company and members of the board of directors, officers and other persons with respect to indemnification; 
 WHEREAS, the Board of Directors of the Company (the “Board”) has determined that the increased difficulty in attracting and retaining highly qualified persons such as Indemnitee is
detrimental to the best interests of the Company’s stockholders; 
 WHEREAS, it is reasonable, prudent and necessary for
the Company contractually to obligate itself to indemnify, and to advance expenses on behalf of, such persons to the fullest extent permitted by applicable law, regardless of any amendment or revocation of the Certificate of Incorporation (as the
same may be amended, restated or otherwise modified from time to time, the “Charter”) or the Bylaws, so that they will serve or continue to serve the Company free from undue concern that they will not be so indemnified; 

WHEREAS, this Agreement is a supplement to and in furtherance of the indemnification provided in the Bylaws and any resolutions adopted
pursuant thereto, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder; and 
 [WHEREAS, Indemnitee has certain rights to indemnification and/or insurance provided by [Name of Fund/Sponsor] which Indemnitee and [Name of Fund/Sponsor] intend to be secondary to the primary obligation
of the Company to indemnify Indemnitee as provided in this Agreement, with the Company’s acknowledgment and agreement to the foregoing being a material condition to Indemnitee’s willingness to serve or continue to serve on the Board.]

 NOW, THEREFORE, in consideration of the premises and the covenants contained herein, the
Company and Indemnitee do hereby covenant and agree as follows: 
 Section 1. Services to the Company. Indemnitee
agrees to serve as a director or officer of the Company. Indemnitee may at any time and for any reason resign from such position (subject to any other contractual obligation or any obligation imposed by law), in which event the Company shall have no
obligation under this Agreement to continue Indemnitee in such position. This Agreement shall not be deemed an employment contract between the Company (or any of its subsidiaries or any Enterprise) and Indemnitee. 

Section 2. Definitions. 
 As used in this Agreement: 
 (a) “Change in Control” shall mean:

 (i) the date any “person,” as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of
1934, as amended (the “Act”) (other than the Company, any of its subsidiaries, or any trustee, fiduciary or other person or entity holding securities under any employee benefit plan or trust of the Company or any of its subsidiaries),
together with all “affiliates” and “associates” (as such terms are defined in Rule 12b-2 under the Act) of such person, becomes the “beneficial owner” (as such term is defined in Rule 13d-3 under the Act), directly or
indirectly, of securities of the Company representing 50 percent or more of the combined voting power of the Company’s then outstanding securities having the right to vote in an election of the Board (“Voting Securities”) (in such
case other than as a result of an acquisition of securities directly from the Company); or 
 (ii) the date a majority of the
members of the Board is replaced during any 12-month period by directors whose appointment or election is not endorsed by a majority of the members of the Board before the date of the appointment or election; or 

(iii) the date of consummation of (A) any consolidation or merger of the Company where the stockholders of the Company, immediately
prior to the consolidation or merger, would not, immediately after the consolidation or merger, beneficially own (as such term is defined in Rule 13d-3 under the Act), directly or indirectly, shares representing in the aggregate more than 50 percent
of the voting shares of the Company issuing cash or securities in the consolidation or merger (or of its ultimate parent corporation, if any), or (B) any sale or other transfer (in one transaction or a series of transactions contemplated or
arranged by any party as a single plan) of all or substantially all of the assets of the Company. 
 Notwithstanding the
foregoing, a “Change in Control” will not be deemed to have occurred for purposes of the foregoing clause (i) solely as the result of an acquisition of securities by the Company which, by reducing the number of shares of Voting
Securities outstanding, increases the proportionate number of Voting Securities beneficially owned by any person to 50 percent or more of the combined voting power of all of the then outstanding Voting Securities; provided, however, that if any
person referred to in this sentence will thereafter 

  
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become the beneficial owner of any additional shares of Voting Securities (other than pursuant to a stock split, stock dividend, or similar transaction or as a result of an acquisition of
securities directly from the Company) and immediately thereafter beneficially owns 50 percent or more of the combined voting power of all of the then outstanding Voting Securities, then a “Change in Control” will be deemed to have occurred
for purposes of the foregoing clause (i). 
 (b) “Corporate Status” describes the status of a person as a
current or former director or officer of the Company or current or former director, manager, officer, employee, agent or trustee of any other Enterprise which such person is or was serving at the request of the Company. 

(c) “Enforcement Expenses” shall include all reasonable attorneys’ fees, court costs, transcript costs, fees of
experts, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees, and all other out-of-pocket disbursements or expenses of the types customarily incurred in connection with an action to
enforce indemnification or advancement rights, or an appeal from such action. Expenses, however, shall not include fees, salaries, wages or benefits owed to Indemnitee. 
 (d) “Enterprise” shall mean any corporation (other than the Company), partnership, joint venture, trust, employee benefit plan, limited liability company, or other legal entity of which
Indemnitee is or was serving at the request of the Company as a director, manager, officer, employee, agent or trustee. 
 (e)
“Expenses” shall include all reasonable attorneys’ fees, court costs, transcript costs, fees of experts, travel expenses, duplicating costs, printing and binding costs, telephone charges, postage, delivery service fees, and all
other out-of-pocket disbursements or expenses of the types customarily incurred in connection with prosecuting, defending, preparing to prosecute or defend, investigating, being or preparing to be a witness in, or otherwise participating in, a
Proceeding or an appeal resulting from a Proceeding. Expenses, however, shall not include amounts paid in settlement by Indemnitee, the amount of judgments or fines against Indemnitee or fees, salaries, wages or benefits owed to Indemnitee.

 (f) “Independent Counsel” means a law firm, or a partner (or, if applicable, member or shareholder) of such
a law firm, that is experienced in matters of Delaware corporation law and neither presently is, nor in the past five (5) years has been, retained to represent: (i) the Company, any subsidiary of the Company, any Enterprise or Indemnitee
in any matter material to any such party (other than with respect to matters concerning Indemnitee under this Agreement, or of other indemnitees under similar indemnification agreements); or (ii) any other party to the Proceeding giving rise to
a claim for indemnification hereunder. Notwithstanding the foregoing, the term “Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of
interest in representing either the Company or Indemnitee in an action to determine Indemnitee’s rights under this Agreement. The Company agrees to pay the reasonable fees and expenses of the Independent Counsel referred to above and to fully
indemnify such counsel against any and all expenses, claims, liabilities and damages arising out of or relating to this Agreement or its engagement pursuant hereto. 

  
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 (g) The term “Proceeding” shall include any threatened, pending or
completed action, suit, arbitration, alternate dispute resolution mechanism, investigation, inquiry, administrative hearing or any other actual, threatened or completed proceeding, whether brought in the right of the Company or otherwise and whether
of a civil, criminal, administrative, regulatory or investigative nature, and whether formal or informal, in which Indemnitee was, is or will be involved as a party or otherwise by reason of the fact that Indemnitee is or was a director or officer
of the Company or is or was serving at the request of the Company as a director, manager, officer, employee, agent or trustee of any Enterprise or by reason of any action taken by Indemnitee or of any action taken on his or her part while acting as
a director or officer of the Company or while serving at the request of the Company as a director, manager, officer, employee, agent or trustee of any Enterprise, in each case whether or not serving in such capacity at the time any liability or
expense is incurred for which indemnification, reimbursement or advancement of expenses can be provided under this Agreement; provided, however, that the term “Proceeding” shall not include any action, suit or arbitration, or part thereof,
initiated by Indemnitee to enforce Indemnitee’s rights under this Agreement as provided for in Section 12(a) of this Agreement. 
 Section 3. Indemnity in Third-Party Proceedings. The Company shall indemnify Indemnitee to the extent set forth in this Section 3 if Indemnitee is, or is threatened to be
made, a party to or a participant in any Proceeding, other than a Proceeding by or in the right of the Company to procure a judgment in its favor. Pursuant to this Section 3, Indemnitee shall be indemnified against all Expenses, judgments,
fines, penalties, excise taxes, and amounts paid in settlement actually and reasonably incurred by Indemnitee or on his or her behalf in connection with such Proceeding or any claim, issue or matter therein, if Indemnitee acted in good faith and in
a manner he or she reasonably believed to be in or not opposed to the best interests of the Company and, in the case of a criminal proceeding, had no reasonable cause to believe that his or her conduct was unlawful.  

Section 4. Indemnity in Proceedings by or in the Right of the Company. The Company shall indemnify Indemnitee to the extent
set forth in this Section 4 if Indemnitee is, or is threatened to be made, a party to or a participant in any Proceeding by or in the right of the Company to procure a judgment in its favor. Pursuant to this Section 4, Indemnitee shall be
indemnified against all Expenses actually and reasonably incurred by him or her or on his or her behalf in connection with such Proceeding or any claim, issue or matter therein, if Indemnitee acted in good faith and in a manner he or she reasonably
believed to be in or not opposed to the best interests of the Company. No indemnification for Expenses shall be made under this Section 4 in respect of any claim, issue or matter as to which Indemnitee shall have been finally adjudged by a
court to be liable to the Company, unless and only to the extent that the Delaware Court of Chancery (the “Delaware Court”) shall determine upon application that, despite the adjudication of liability but in view of all the
circumstances of the case, Indemnitee is fairly and reasonably entitled to indemnification for such expenses as the Delaware Court shall deem proper. 

  
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 Section 5. Indemnification for Expenses of a Party Who is Wholly or Partly
Successful. Notwithstanding any other provisions of this Agreement and except as provided in Section 7, to the extent that Indemnitee is a party to or a participant in any Proceeding and is successful in such Proceeding or in defense of any
claim, issue or matter therein, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or her in connection therewith. If Indemnitee is not wholly successful in such Proceeding but is successful as to one
or more but less than all claims, issues or matters in such Proceeding, the Company shall indemnify Indemnitee against all Expenses actually and reasonably incurred by him or her or on his or her behalf in connection with each successfully resolved
claim, issue or matter. For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Proceeding by dismissal, with or without prejudice, shall be deemed to be a successful result as to such claim,
issue or matter. 
 Section 6. Reimbursement for Expenses of a Witness or in Response to a Subpoena. Notwithstanding
any other provision of this Agreement, to the extent that Indemnitee, by reason of his or her Corporate Status, (i) is a witness in any Proceeding to which Indemnitee is not a party and is not threatened to be made a party or (ii) receives
a subpoena with respect to any Proceeding to which Indemnitee is not a party and is not threatened to be made a party, the Company shall reimburse Indemnitee for all Expenses actually and reasonably incurred by him or her or on his or her behalf in
connection therewith. 
 Section 7. Exclusions. Notwithstanding any provision in this Agreement to the
contrary, the Company shall not be obligated under this Agreement:  
 (a) to indemnify for amounts otherwise
indemnifiable hereunder (or for which advancement is provided hereunder) if and to the extent that Indemnitee has otherwise actually received such amounts under any insurance policy, contract, agreement or otherwise[; provided that the foregoing
shall not affect the rights of Indemnitee or the Fund Indemnitors as set forth in Section 14(c)]; 
 (b) to indemnify for
an accounting of profits made from the purchase and sale (or sale and purchase) by Indemnitee of securities of the Company within the meaning of Section 16(b) of the Securities Exchange Act of 1934, as amended, or similar provisions of state
statutory law or common law; 
 (c) to indemnify for any reimbursement of, or payment to, the Company by Indemnitee of any bonus
or other incentive-based or equity-based compensation or of any profits realized by Indemnitee from the sale of securities of the Company pursuant to Section 304 of the Sarbanes-Oxley Act of 2002 (“SOX”) or any formal policy of
the Company adopted by the Board (or a committee thereof), or any other remuneration paid to Indemnitee if it shall be determined by a final judgment or other final adjudication that such remuneration was in violation of law; 

(d) to indemnify with respect to any Proceeding, or part thereof, brought by Indemnitee against the Company, any legal entity which it
controls, any director or officer thereof or any third party, unless (i) the Board has consented to the initiation of such Proceeding or part thereof and (ii) the Company provides the indemnification, in its sole discretion, pursuant to
the powers vested in the Company under applicable law; provided, however, that this Section 7(d) shall not apply to counterclaims or affirmative defenses asserted by Indemnitee in an action brought against Indemnitee; or 

  
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 (e) to provide any indemnification or advancement of expenses that is prohibited by
applicable law (as such law exists at the time payment would otherwise be required pursuant to this Agreement). 

Section 8. Advancement of Expenses. Subject to Section 9(b), the Company shall advance, to the extent not prohibited by
law, the Expenses incurred by Indemnitee in connection with any Proceeding, and such advancement shall be made within thirty (30) days after the receipt by the Company of a statement or statements requesting such advances (which shall include
invoices received by Indemnitee in connection with such Expenses but, in the case of invoices in connection with legal services, any references to legal work performed or to expenditures made that would cause Indemnitee to waive any privilege
accorded by applicable law shall not be included with the invoice) from time to time, whether prior to or after final disposition of any Proceeding. Advances shall be unsecured and interest free. Advances shall be made without regard to
Indemnitee’s ability to repay the expenses and without regard to Indemnitee’s ultimate entitlement to indemnification under the other provisions of this Agreement. Indemnitee shall qualify for advances upon the execution and delivery to
the Company of an undertaking to repay the advance if and to the extent it is ultimately determined that Indemnitee is not entitled to indemnification, in the form attached hereto as Exhibit A. The right to advances under this paragraph shall
in all events continue until final disposition of any Proceeding, including any appeal therein. Nothing in this Section 8 shall limit Indemnitee’s right to advancement pursuant to Section 12(e) of this Agreement. 

Section 9. Procedure for Notification and Defense of Claim. 

(a) To obtain indemnification under this Agreement, Indemnitee shall submit to the Company a written request therefor specifying the
basis for the claim, the amounts for which Indemnitee is seeking payment under this Agreement, and all documentation related thereto as reasonably requested by the Company. 
 (b) In the event that the Company shall be obligated hereunder to provide indemnification for or make any advancement of Expenses with respect to any Proceeding, the Company shall be entitled to assume
the defense of such Proceeding, or any claim, issue or matter therein, with counsel approved by Indemnitee (which approval shall not be unreasonably withheld or delayed) upon the delivery to Indemnitee of written notice of the Company’s
election to do so. After delivery of such notice, approval of such counsel by Indemnitee and the retention of such counsel by the Company, the Company will not be liable to Indemnitee under this Agreement for any fees or expenses of separate counsel
subsequently employed by or on behalf of Indemnitee with respect to the same Proceeding; provided that (i) Indemnitee shall have the right to employ separate counsel in any such Proceeding at Indemnitee’s expense and (ii) if
(A) the employment of separate counsel by Indemnitee has been previously authorized by the Company, (B) Indemnitee shall have reasonably concluded that there may be a conflict of interest between the Company and Indemnitee in the conduct
of such defense, or (C) the Company shall not continue to retain such counsel to defend such Proceeding, then the reasonable fees and expenses actually and reasonably incurred by Indemnitee with respect to his or her separate counsel shall be
Expenses hereunder. 

  
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 (c) In the event that the Company does not assume the defense in a Proceeding pursuant to
paragraph (b) above, then the Company will be entitled to participate in the Proceeding at its own expense. 
 (d) The
Company shall not be liable to indemnify Indemnitee under this Agreement for any amounts paid in settlement of any Proceeding effected without its prior written consent (which consent shall not be unreasonably withheld or delayed). The Company shall
not, without the prior written consent of Indemnitee (which consent shall not be unreasonably withheld or delayed), enter into any settlement which (i) includes an admission of fault of Indemnitee, any non-monetary remedy imposed on Indemnitee
or any monetary damages for which Indemnitee is not wholly and actually indemnified hereunder or (ii) with respect to any Proceeding with respect to which Indemnitee may be or is made a party or may be otherwise entitled to seek indemnification
hereunder, does not include the full release of Indemnitee from all liability in respect of such Proceeding. 
 Section 10.
Procedure Upon Application for Indemnification. 
 (a) To the extent that Indemnitee shall have been successful on the
merits in any Proceeding to which it is a party or a participant or in defense of any claim, issue or matter therein, no determination shall be required to be made with respect to Indemnitee’s entitlement to indemnification hereunder. In all
other cases, a determination with respect to Indemnitee’s entitlement to indemnification hereunder shall be made in the specific case by one of the following methods: (x) if a Change in Control shall have occurred, (i) by Independent
Counsel in a written opinion to the Board or (ii) if the Indemnitee so requests in writing, by a majority vote of the disinterested directors, even though less than a quorum; or (y) if a Change in Control shall not have occurred:
(i) by a majority vote of the disinterested directors, even though less than a quorum; (ii) by a committee of disinterested directors designated by a majority vote of the disinterested directors, even though less than a quorum;
(iii) if there are no disinterested directors or if the disinterested directors so direct, by Independent Counsel in a written opinion to the Board; or (iv) if so directed by the Board, by the stockholders of the Company. For purposes
hereof, disinterested directors are those members of the Board who are not parties to the action, suit or proceeding in respect of which indemnification is sought. In the case that such determination is made by Independent Counsel, a copy of
Independent Counsel’s written opinion shall be delivered to Indemnitee and, if it is so determined that Indemnitee is entitled to indemnification, payment to Indemnitee shall be made within thirty (30) days after such determination.
Indemnitee shall cooperate with the Independent Counsel or the Company, as applicable, in making such determination with respect to Indemnitee’s entitlement to indemnification, including providing to such counsel or the Company, upon reasonable
advance request, any documentation or information which is not privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee and reasonably necessary to such determination. Any out-of-pocket costs or expenses
(including reasonable attorneys’ fees and disbursements) actually and reasonably incurred by Indemnitee in so cooperating with the Independent Counsel or the Company shall be borne by the Company (irrespective of the determination as to
Indemnitee’s entitlement to indemnification) and the Company hereby indemnifies and agrees to hold Indemnitee harmless therefrom. 

  
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 (b) If the determination of entitlement to indemnification is to be made by Independent
Counsel pursuant to Section 10(a), the Independent Counsel shall be selected by the Board if a Change in Control shall not have occurred or, if a Change in Control shall have occurred, by Indemnitee. Indemnitee or the Company, as the case may
be, may, within ten (10) days after written notice of such selection, deliver to the Company or Indemnitee, as the case may be, a written objection to such selection; provided, however, that such objection may be asserted only on the ground
that the Independent Counsel so selected does not meet the requirements of “Independent Counsel” as defined in Section 2 of this Agreement, and the objection shall set forth with particularity the factual basis of such assertion.
Absent a proper and timely objection, the person so selected shall act as Independent Counsel. If such written objection is so made and substantiated, the Independent Counsel so selected may not serve as Independent Counsel unless and until such
objection is withdrawn or the Delaware Court has determined that such objection is without merit. If, within twenty (20) days after the later of (i) submission by Indemnitee of a written request for indemnification pursuant to
Section 9(a), and (ii) the final disposition of the Proceeding, including any appeal therein, no Independent Counsel shall have been selected without objection, either Indemnitee or the Company may petition the Delaware Court for
resolution of any objection which shall have been made by Indemnitee or the Company to the selection of Independent Counsel and/or for the appointment as Independent Counsel of a person selected by the court or by such other person as the court
shall designate. The person with respect to whom all objections are so resolved or the person so appointed shall act as Independent Counsel under Section 10(a) hereof. Upon the due commencement of any judicial proceeding or arbitration pursuant
to Section 12(a) of this Agreement, Independent Counsel shall be discharged and relieved of any further responsibility in such capacity (subject to the applicable standards of professional conduct then prevailing). 

Section 11. Presumptions and Effect of Certain Proceedings. 

(a) To the extent permitted by applicable law, in making a determination with respect to entitlement to indemnification hereunder, it
shall be presumed that Indemnitee is entitled to indemnification under this Agreement if Indemnitee has submitted a request for indemnification in accordance with Section 9(a) of this Agreement, and the Company shall have the burden of proof to
overcome that presumption in connection with the making of any determination contrary to that presumption. Neither (i) the failure of the Company or of Independent Counsel to have made a determination prior to the commencement of any action
pursuant to this Agreement that indemnification is proper in the circumstances because Indemnitee has met the applicable standard of conduct, nor (ii) an actual determination by the Company or by Independent Counsel that Indemnitee has not met
such applicable standard of conduct, shall be a defense to the action or create a presumption that Indemnitee has not met the applicable standard of conduct. 
 (b) The termination of any Proceeding or of any claim, issue or matter therein, by judgment, order, settlement or conviction, or upon a plea of guilty, nolo contendere or its equivalent, shall not (except
as otherwise expressly provided in this Agreement) of itself adversely affect the right of Indemnitee to indemnification or create a presumption that 

  
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Indemnitee did not act in good faith and in a manner which he or she reasonably believed to be in or not opposed to the best interests of the Company or, with respect to any criminal Proceeding,
that Indemnitee had reasonable cause to believe that his or her conduct was unlawful. 
 (c) The knowledge and/or actions, or
failure to act, of any director, manager, officer, employee, agent or trustee of the Company, any subsidiary of the Company, or any Enterprise shall not be imputed to Indemnitee for purposes of determining the right to indemnification under this
Agreement. 
 Section 12. Remedies of Indemnitee. 

(a) Subject to Section 12(f), in the event that (i) a determination is made pursuant to Section 10 of this Agreement that
Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 8 of this Agreement, (iii) no determination of entitlement to indemnification shall have been made
pursuant to Section 10(a) of this Agreement within sixty (60) days after receipt by the Company of the request for indemnification for which a determination is to be made other than by Independent Counsel, (iv) payment of
indemnification or reimbursement of expenses is not made pursuant to Section 5 or 6 or the last sentence of Section 10(a) of this Agreement within thirty (30) days after receipt by the Company of a written request therefor (which
shall include any invoices received by Indemnitee but, in the case of invoices in connection with legal services, any references to legal work performed or to expenditures made that would cause Indemnitee to waive any privilege accorded by
applicable law shall not be included with the invoice) or (v) payment of indemnification pursuant to Section 3 or 4 of this Agreement is not made within thirty (30) days after a determination has been made that Indemnitee is entitled
to indemnification, Indemnitee shall be entitled to an adjudication by the Delaware Court of his or her entitlement to such indemnification or advancement. Alternatively, Indemnitee, at his or her option, may seek an award in arbitration to be
conducted by a single arbitrator pursuant to the Commercial Arbitration Rules of the American Arbitration Association. Indemnitee shall commence such proceeding seeking an adjudication or an award in arbitration within 180 days following the date on
which Indemnitee first has the right to commence such proceeding pursuant to this Section 12(a); provided, however, that the foregoing time limitation shall not apply in respect of a proceeding brought by Indemnitee to enforce his or her rights
under Section 5 of this Agreement. The Company shall not oppose Indemnitee’s right to seek any such adjudication or award in arbitration. 
 (b) In the event that a determination shall have been made pursuant to Section 10(a) of this Agreement that Indemnitee is not entitled to indemnification, any judicial proceeding or arbitration
commenced pursuant to this Section 12 shall be conducted in all respects as a de novo trial, or arbitration, on the merits and Indemnitee shall not be prejudiced by reason of that adverse determination. In any judicial proceeding or arbitration
commenced pursuant to this Section 12, the Company shall have the burden of proving Indemnitee is not entitled to indemnification or advancement, as the case may be. 

  
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 (c) If Indemnitee is entitled to indemnification pursuant to Section 10(a) of this
Agreement, the Company shall be bound by such provision and/or determination in any judicial proceeding or arbitration commenced pursuant to this Section 12, absent (i) a misstatement by Indemnitee of a material fact, or an omission of a
material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of such indemnification under applicable law. 

(d) The Company shall be precluded from asserting in any judicial proceeding or arbitration commenced pursuant to this Section 12
that the procedures and presumptions of this Agreement are not valid, binding and enforceable and shall stipulate in any such court or before any such arbitrator that the Company is bound by all the provisions of this Agreement. 

(e) The Company shall indemnify Indemnitee to the fullest extent permitted by law against any and all Enforcement Expenses and, if
requested by Indemnitee, shall (within thirty (30) days after receipt by the Company of a written request therefor) advance, to the extent not prohibited by law, such Enforcement Expenses to Indemnitee, which are incurred by Indemnitee in
connection with any action brought by Indemnitee for indemnification or advancement from the Company under this Agreement or under any directors’ and officers’ liability insurance policies maintained by the Company in the suit for which
indemnification or advancement is being sought. Such written request for advancement shall include invoices received by Indemnitee in connection with such Enforcement Expenses but, in the case of invoices in connection with legal services, any
references to legal work performed or to expenditures made that would cause Indemnitee to waive any privilege accorded by applicable law shall not be included with the invoice. 

(f) Notwithstanding anything in this Agreement to the contrary, no determination as to entitlement to indemnification under this
Agreement shall be required to be made prior to the final disposition of the Proceeding, including any appeal therein. 

  
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 Section 13. Non-exclusivity; Survival of Rights; Insurance; [Primacy of
Indemnification;] Subrogation. 
 (a) The rights of indemnification and to receive advancement as provided by this Agreement
shall not be deemed exclusive of any other rights to which Indemnitee may at any time be entitled under applicable law, the Charter, the Bylaws, any agreement, a vote of stockholders or a resolution of directors, or otherwise. No amendment,
alteration or repeal of this Agreement or of any provision hereof shall limit or restrict any right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee in his or her Corporate Status prior to such
amendment, alteration or repeal. To the extent that a change in Delaware law, whether by statute or judicial decision, permits greater indemnification or advancement than would be afforded currently under the Charter, Bylaws and this Agreement, it
is the intent of the parties hereto that Indemnitee shall enjoy by this Agreement the greater benefits so afforded by such change. No right or remedy herein conferred is intended to be exclusive of any other right or remedy, and every other right
and remedy shall be cumulative and in addition to every other right and remedy given hereunder or now or hereafter existing at law or in equity or otherwise. The assertion or employment of any right or remedy hereunder, or otherwise, shall not
prevent the concurrent assertion or employment of any other right or remedy. 
 (b) To the extent that the Company maintains an
insurance policy or policies providing liability insurance for directors, managers, officers, employees, agents or trustees of the Company or of any other Enterprise, Indemnitee shall be covered by such policy or policies in accordance with its or
their terms to the maximum extent of the coverage available for any such director, manager, officer, employee, agent or trustee under such policy or policies. If, at the time of the receipt of a notice of a claim pursuant to the terms hereof, the
Company has director and officer liability insurance in effect, the Company shall give prompt notice of the commencement of such proceeding to the insurers in accordance with the procedures set forth in the respective policies. The Company shall
thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of Indemnitee, all amounts payable as a result of such proceeding in accordance with the terms of such policies. 

(c) [The Company hereby acknowledges that Indemnitee has certain rights to indemnification, advancement of expenses and/or insurance
provided by [Name of Fund/Sponsor] and certain of its affiliates (collectively, the “Fund Indemnitors”). The Company hereby agrees (i) that it is the indemnitor of first resort (i.e., its obligations to Indemnitee are
primary and any obligation of the Fund Indemnitors to advance expenses or to provide indemnification for the same expenses or liabilities incurred by Indemnitee are secondary), (ii) that it shall be required to advance the full amount of
expenses incurred by Indemnitee and shall be liable for the full amount of all Expenses, judgments, penalties, fines and amounts paid in settlement to the extent legally permitted and as required by the terms of this Agreement and the Charter and/or
Bylaws (or any other agreement between the Company and Indemnitee), without regard to any rights Indemnitee may have against the Fund Indemnitors, and (iii) that it irrevocably waives, relinquishes and releases the Fund Indemnitors from any and
all claims against the Fund Indemnitors for contribution, subrogation or any other recovery of any kind in respect thereof. The Company further agrees that no advancement or payment by the Fund Indemnitors on behalf of Indemnitee with respect to any
claim for which Indemnitee has sought indemnification from the Company shall affect the foregoing and the Fund Indemnitors 

  
 11 

 
shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of Indemnitee against the Company. The Company and Indemnitee
agree that the Fund Indemnitors are express third party beneficiaries of the terms of this Section 8(c).] 
 (d) [Except as
provided in paragraph (c) above,] [I/i]n the event of any payment under this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee [(other than against the Fund Indemnitors)],
who shall execute all papers required and take all action necessary to secure such rights, including execution of such documents as are necessary to enable the Company to bring suit to enforce such rights. 

(e) [Except as provided in paragraph (c) above,] [T/t]he Company’s obligation to provide indemnification or advancement
hereunder to Indemnitee who is or was serving at the request of the Company as a director, manager, officer, employee, agent or trustee of any other Enterprise shall be reduced by any amount Indemnitee has actually received as indemnification or
advancement from such other Enterprise. 
 Section 14. Duration of Agreement. This Agreement shall continue until
and terminate upon the later of: (a) ten (10) years after the date that Indemnitee shall have ceased to serve as a director or officer of the Company or (b) one (1) year after the final termination of any Proceeding, including
any appeal, then pending in respect of which Indemnitee is granted rights of indemnification or advancement hereunder and of any proceeding commenced by Indemnitee pursuant to Section 12 of this Agreement relating thereto. This Agreement shall
be binding upon the Company and its successors and assigns and shall inure to the benefit of Indemnitee and his or her heirs, executors and administrators. The Company shall require and cause any successor (whether direct or indirect by purchase,
merger, consolidation or otherwise) to all, substantially all or a substantial part, of the business and/or assets of the Company, by written agreement in form and substance satisfactory to Indemnitee, expressly to assume and agree to perform this
Agreement in the same manner and to the same extent that the Company would be required to perform if no such succession had taken place. 
 Section 15. Severability. If any provision or provisions of this Agreement shall be held to be invalid, illegal or unenforceable for any reason whatsoever: (a) the validity, legality and
enforceability of the remaining provisions of this Agreement (including, without limitation, each portion of any section of this Agreement containing any such provision held to be invalid, illegal or unenforceable, that is not itself invalid,
illegal or unenforceable) shall not in any way be affected or impaired thereby and shall remain enforceable to the fullest extent permitted by law; (b) such provision or provisions shall be deemed reformed to the extent necessary to conform to
applicable law and to give the maximum effect to the intent of the parties hereto; and (c) to the fullest extent possible, the provisions of this Agreement (including, without limitation, each portion of any section of this Agreement containing
any such provision held to be invalid, illegal or unenforceable, that is not itself invalid, illegal or unenforceable) shall be construed so as to give effect to the intent manifested thereby. 

  
 12 

 Section 16. Enforcement. 

(a) The Company expressly confirms and agrees that it has entered into this Agreement and assumed the obligations imposed on it hereby in
order to induce Indemnitee to serve or continue to serve as a director or officer of the Company, and the Company acknowledges that Indemnitee is relying upon this Agreement in serving as a director or officer of the Company. 

(b) This Agreement constitutes the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes
all prior agreements and understandings, oral, written and implied, between the parties hereto with respect to the subject matter hereof; provided, however, that this Agreement is a supplement to and in furtherance of the Charter, the Bylaws and
applicable law, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder. 

Section 17. Modification and Waiver. No supplement, modification or amendment, or waiver of any provision, of this Agreement
shall be binding unless executed in writing by the parties thereto. No waiver of any of the provisions of this Agreement shall be deemed or shall constitute a waiver of any other provisions of this Agreement nor shall any waiver constitute a
continuing waiver. No supplement, modification or amendment of this Agreement or of any provision hereof shall limit or restrict any right of Indemnitee under this Agreement in respect of any action taken or omitted by such Indemnitee prior to such
supplement, modification or amendment. 
 Section 18. Notice by Indemnitee. Indemnitee agrees promptly to notify the
Company in writing upon being served with any summons, citation, subpoena, complaint, indictment, information or other document relating to any Proceeding or matter which may be subject to indemnification, reimbursement or advancement as provided
hereunder. The failure of Indemnitee to so notify the Company shall not relieve the Company of any obligation which it may have to Indemnitee under this Agreement or otherwise. 

Section 19. Notices. All notices, requests, demands and other communications under this Agreement shall be in writing and
shall be deemed to have been duly given if (a) delivered by hand and receipted for by the party to whom said notice or other communication shall have been directed, (b) mailed by certified or registered mail with postage prepaid, on the
third business day after the date on which it is so mailed, (c) mailed by reputable overnight courier and receipted for by the party to whom said notice or other communication shall have been directed or (d) sent by facsimile transmission,
with receipt of oral confirmation that such transmission has been received: 
  

	 	(a)	If to Indemnitee, at such address as Indemnitee shall provide to the Company. 

  
 13 

	 	(b)	If to the Company to: 

 bluebird
bio, Inc. 
 840 Memorial Drive, 4th Floor 
 Cambridge, MA 02139 
 Attention: Counsel 

or to any other address as may have been furnished to Indemnitee by the Company. 

Section 20. Contribution. To the fullest extent permissible under applicable law, if the indemnification provided for in this
Agreement is unavailable to Indemnitee for any reason whatsoever, the Company, in lieu of indemnifying Indemnitee, shall contribute to the amount incurred by Indemnitee, whether for judgments, fines, penalties, excise taxes, amounts paid or to be
paid in settlement and/or for Expenses, in connection with any Proceeding in such proportion as is deemed fair and reasonable in light of all of the circumstances in order to reflect (i) the relative benefits received by the Company and
Indemnitee in connection with the event(s) and/or transaction(s) giving rise to such Proceeding; and/or (ii) the relative fault of the Company (and its directors, officers, employees and agents) and Indemnitee in connection with such event(s)
and/or transactions. 
 Section 21. Internal Revenue Code Section 409A. The Company intends for this Agreement
to comply with the Indemnification exception under Section 1.409A-1(b)(10) of the regulations promulgated under the Internal Revenue Code of 1986, as amended (the “Code”), which provides that indemnification of, or the purchase
of an insurance policy providing for payments of, all or part of the expenses incurred or damages paid or payable by the Indemnitee with respect to a bona fide claim against the Indemnitee or the Company do not provide for a deferral of
compensation, subject to Section 409A of the Code, where such claim is based on actions or failures to act by the Indemnitee in his capacity as a service provider of the Company. The parties intend that this Agreement be interpreted and
construed with such intent. 
 Section 22. Applicable Law and Consent to Jurisdiction. This Agreement and the legal
relations among the parties shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware, without regard to its conflict of laws rules. Except with respect to any arbitration commenced by Indemnitee pursuant
to Section 12(a) of this Agreement, the Company and Indemnitee hereby irrevocably and unconditionally (i) agree that any action or proceeding arising out of or in connection with this Agreement shall be brought only in the Delaware Court,
and not in any other state or federal court in the United States of America or any court in any other country, (ii) consent to submit to the exclusive jurisdiction of the Delaware Court for purposes of any action or proceeding arising out of or
in connection with this Agreement, (iii) consent to service of process at the address set forth in Section 19 of this Agreement with the same legal force and validity as if served upon such party personally within the State of Delaware,
(iv) waive any objection to the laying of venue of any such action or proceeding in the Delaware Court, and (v) waive, and agree not to plead or to make, any claim that any such action or proceeding brought in the Delaware Court has been
brought in an improper or inconvenient forum. 

  
 14 

 Section 23. Headings. The headings of the paragraphs of this Agreement are
inserted for convenience only and shall not be deemed to constitute part of this Agreement or to affect the construction thereof. 
 Section 24. Identical Counterparts. This Agreement may be executed in one or more counterparts, each of which shall for all purposes be deemed to be an original but all of which together shall
constitute one and the same Agreement. Only one such counterpart signed by the party against whom enforceability is sought needs to be produced to evidence the existence of this Agreement. 

[Remainder of Page Intentionally Left Blank] 

  
 15 

 IN WITNESS WHEREOF, the parties have caused this Agreement to be signed as of the day and
year first above written. 
  

			
	bluebird bio, Inc.
		
	By:	 	 
		 	Name:
		 	Title:
		
		 	 
		 	[Name of Indemnitee]

 Exhibit A 
 Form of Undertaking 
 [Date] 

bluebird bio, Inc. 
 840
Memorial Drive, 4th Floor 

Cambridge, MA 02139 
  

	Re:	Request for Advancement of Expenses 

 Ladies and Gentlemen: 
 Reference is made to the Indemnification Agreement (the
“Agreement”) by and between bluebird bio, Inc. (the “Company”) and the undersigned,
                    (“Indemnitee”). Capitalized terms not defined herein shall have those meanings as set forth in the
Agreement. Pursuant to Section 8 of the Agreement, Indemnitee hereby requests advancement of Expenses incurred as a result of Indemnitee being, or being threatened to be made, a party in the following Proceeding(s):
                                         
   . 
 In accordance with Section 8 of the Agreement, Indemnitee undertakes to repay the advancement of Expenses if it
shall ultimately be determined that Indemnitee is not entitled to be indemnified by the Company as authorized by Section 145 of the General Corporation Law of the State of Delaware. 
 Very truly yours, 

                         
       , IndemniteeEX-10.5

 Exhibit 10.5 
 RIVERSIDE TECHNOLOGY CENTER 
 AMENDED AND RESTATED LEASE AGREEMENT

 Agreement entered into this 18th day of May, 2007 by and between Rivertech Associates II, LLC, a Massachusetts limited liability company with a
principal address at The Abbey Group, 575 Boylston Street Boston, Massachusetts (the “LESSOR”), and Genetix Pharmaceuticals, Inc. a corporation with a principal address at 840 Memorial Drive Cambridge, Massachusetts (the
“LESSEE”); relative to certain space in the building owned by the LESSOR at 840 Memorial Drive Cambridge, Massachusetts (the “Building”), as follows: 
 WHEREAS, Rivertech Associates, LLC and Genetix Pharmaceuticals, Inc. entered into a certain lease agreement dated February 18, 2000 (the “Original Lease”); and, 

WHEREAS, LESSOR and LESSEE each hereby represent to the other that as of the date hereof the foregoing Original Lease
represents the full and complete agreement relative to LESSEE’S use and occupancy of certain space described thereunder, consisting (prior to this “Amended and Restated Lease Agreement”) of approximately 10,593 rentable square feet of
space on the fifth (5th) floor of the Building, which
space is specifically referred to herein as the “Current Leased Premises”; and, 
 WHEREAS, certain space
consisting of approximately 10,500 rentable square feet of space on the third (3rd) floor of the Building (the “Substituted Leased Premises”), is available as of June 1, 2007 and LESSOR has reached agreement with LESSEE for LESSEE to surrender the Current Leased
Premises as of the date (the “Substitution Date”) the Substituted Leased Premises are delivered to Tenant in accordance with Section 5 hereof (anticipated to be June 1, 2007), and to lease the Substituted Leased Premises as of
the Substitution Date under the terms and conditions of the Lease as revised and amended by this Amended and Restated Lease Agreement; and, 

NOW THEREFORE, for One ($1.00) Dollar and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the
parties hereto agree as follows: 
  

	1.	Original Term Expiration and Commencement of the Extended Lease Term 

 The current Term under the Original Lease, prior to this Amended and Restated Lease Agreement, expires on June 30, 2007. Effective as of the Substitution Date, LESSEE shall vacate and surrender the
Current Leased Premises to LESSOR and LESSOR shall accept such surrender from LESSEE and the Original Lease shall be deemed terminated provided that Subtenant shall have access to the Current Leased Premises for a period of up to thirty
(30) days after the Substitution Date in order to satisfy the provisions of the Original Lease pertaining to the condition in which the Current Leased Premises are to be delivered to LESSOR (e.g. Lease Sections 26 and 28), and to effectuate the
transfer of LESSEE’S equipment and furniture from the Current Leased Premises to the Substituted Leased Premises in a timely and orderly manner. 

  
 1 

 As of the Substitution Date, the Term of the Original Lease (as amended by this Amended and Restated Lease
Agreement) will be extended for a period beginning on the Substitution Date and expiring on May 31, 2010 (the “Extended Term”); and LESSEE shall lease the Substituted Leased Premises under the Rent, terms and conditions as set forth
in this Amended and Restated Lease Agreement up to the expiration of said Extended Term. 
 To the extent LESSOR cannot deliver the Substituted
Leased Premises to LESSEE on or prior to June 30, 2007, the term of the Original Lease shall be automatically extended through that date which subsequently becomes the Substitution Date, except that the Rent thereunder shall be amended to be
equal to the Rent for the Substituted Leased Premises during the first Lease Year of the Extended Term. 
 The term “Lease Year” as
used herein and for all purposes during the Extended Term shall mean the period beginning on the Substitution Date and ending on the day immediately prior to each anniversary of the Substitution Date, provided that the Third Lease Year shall end on
May 31, 2010. 
  

	2.	The Substituted Leased Premises 

 LESSOR
and LESSEE hereby agree that during the Extended Term, the Substituted Leased Premises, as defined herein and as depicted on Exhibit A attached hereto, shall be deemed to mean the “Leased Premises” as referred to in the Lease, unless the
context specifically means the “Current Leased Premises.” 
 The Substituted Leased Premises may be used by LESSEE for general office,
research and laboratory uses only, as set forth in Section 6 of the Lease, throughout the Extended Term. 
 Provided the same does not
materially interfere with LESSOR’S obligations under Section 5 hereof (in which case LESSEE’S rights under this paragraph shall be expressly subordinate in LESSOR’S sole discretion). LESSEE shall have reasonable supervised access
to the Substituted Leased Premises commencing on the date of this Agreement to install trade fixtures and/or cabling and/or communications equipment, and to reconfigure and move laboratory and office equipment. Such early access by LESSEE shall be
subject to such times and in such manner as LESSOR may reasonably determine to avoid material interference with LESSOR’S Work. 
 LESSEE
shall not be charged any fees by LESSOR for use of the freight elevators of the building, supervision or otherwise in connection with LESSEE’S move from the Current Leased Premises to the Substituted Leased Premises. 

LESSOR shall provide the services of LESSOR’S internal space planning and design staff, at LESSOR’S cost and expense, on a reasonable basis to
assist LESSEE in its own space planning and design. 
  

	3.	Annual Base Rent—Revised Annual Base Rent Schedule 

 Commencing as of the beginning of the Extended Term, LESSEE’S monthly installments of Annual Base Rent for the Leased Premises shall be based on Annual Base Rent as set forth in the “Revised
Annual Base Rent Schedule” appearing below. 

  
 2 

 Revised Annual Base Rent Schedule 

 

					
	 First Lease Year
	  	$	 388,500.00 	($ 32,375.00/mo.) 
	 Second Lease Year
	  	$	 399,000.00 	($ 33,250.00/mo.) 
	 Third Lease Year
	  	$	 420,000.00 	($ 35,000.00/mo.) 

 Annual Base Rent shall be payable by Lessee for each Lease Year of the Extended Term as set forth above in twelve
installments during each Lease Year (reflecting the aforesaid Revised Annual Base Rent Schedule), in advance, on or before the first day of each calendar month. 
 Except as otherwise set forth in Section I on account of the Substitution Date occurring after June 30, 2007, LESSEE shall continue to pay Annual Base Rent under the Original Lease for the Current
Leased Premises up to the Substitution Date. 
  

	4.	Additional Rent 

 Notwithstanding the
provisions of the Original Lease, this Amended and Restated Lease Agreement is structured as a “triple net” lease. Accordingly, the provisions for Additional Rent based on Operating Expenses and Taxes are rewritten as follows. 

LESSEE shall also pay to LESSOR, as Additional Rent under the Lease, the following amounts based on LESSEE’S allocable percentage (which is 8.3441%,
the ‘‘Allocable Percentage”): 
 A. Operating Expenses: LESSEE shall be responsible for payment of Additional Rent attributable
to the Operating Expenses for the Building and site, based on LESSEE’S Allocable Percentage. Operating Expenses, as set forth in Exhibit B hereto, are the unaudited actuals for calendar year 2006 (and will be subject to change based on actual
costs and expenses incurred for each of the categorized Exhibit B costs and expenses in 2007 and each subsequent year during the Extended Term). “Operating Expenses” shall not include the following: the costs of LESSEE’S improvements
and services for which LESSEE or any tenant specifically and directly reimburses LESSOR, or pays third persons at LESSOR’S directions; income or franchise taxes of the LESSOR; the costs incurred in any rehabilitation, reconstruction or other
work occasioned by any insured casualty (i.e. as to which LESSOR is required to carry insurance hereunder), or by the exercise of the right of eminent domain (except to the extent of any so-called “deductible” amount under policies of
insurance or any costs actually incurred for which any insurance company does not reimburse or compensate LESSOR or Owner); depreciation of the Building; general corporate overhead of the LESSOR entity; legal expenses incurred in any direct dispute
with any particular tenant (other than those incurred which are of benefit to or protect the rights of other tenants in the Building, generally); costs of renovations to other tenants’ spaces; costs of capital improvements; brokerage and
advertising costs in seeking new tenants; and penalties incurred due to LESSOR’S willful violation of any direct violation of any government order. 
 B. Tax Expenses: LESSEE shall be responsible for payment of Additional Rent attributable to the municipal real estate taxes on the Building and land on which it is situated, based on LESSEE’S
Allocable Percentage. 
 Additional Rent for Operating Expenses and Tax Expenses shall be payable as invoiced by LESSOR (accompanied by a copy
of the applicable municipal tax bill), and failure to make any such payments within thirty (30) days of such invoice shall be a default under this Amended and Restated Lease Agreement. 

  
 3 

 C. Utilities: Landlord shall provide and Tenant shall pay utilities attributable to the Substituted Leased
Premises as set forth in Section 7 of the Original Lease. 
  

	5.	Condition of the Current Leased Premises on the Substitution Date; and Landlord’s Work on the Substituted Leased Premises 

The Current Leased Premises shall be vacated and surrendered by the LESSEE in accordance with the provisions of Sections 26 and 28 of the Lease, upon
delivery of the Substituted Leased Premises to the LESSEE by the LESSOR as contemplated herein. 
 LESSOR and LESSEE acknowledge that LESSOR
shall deliver and LESSEE shall accept delivery of the Substituted Leased Premises as of the beginning of the Extended Term in an AS/IS condition in all respects, but for: (a) the specific work to be performed by LESSOR as set forth in Exhibit C
hereto (the “LESSOR’S Work”); (b) in vacant and clean condition; (c) with the laboratory areas “decommissioned” (i.e. free of any environmental hazards or materials such that it is not in violation of applicable
environmental laws consistent with the same standards set forth in Section 26 of the Lease) and sanitized. Landlord represents that the Substituted Leased Premises currently has the benefit of a certificate of occupancy from the City of
Cambridge therefor which permits the use of the Substituted Leased Premises for the uses permitted under this Lease, and to the extent any additional building permit (or resulting certificate of occupancy is required on account of LESSOR’S
Work), then LESSOR shall be required to procure and deliver the same to LESSEE. LESSOR’S Work shall be performed at LESSOR’S sole cost and expense, and shall be substantially completed as of the beginning of the Extended Term. LESSOR shall
perform LESSOR’S Work in a good and workmanlike manner and in compliance with all applicable laws and governmental regulations. LESSEE shall inspect such work upon delivery by LESSOR, and hereby acknowledges there are no special installations
or other requirements with respect thereto which do not appear on Exhibit C hereto. Notwithstanding LESSOR’S obligation to perform LESSOR’S Work, LESSOR shall not be liable for any damages resulting from LESSEE’S transfer of its
operations and equipment from the Current Leased Premises to the Substituted Leased Premises or performance of any of its business functions (e.g. laboratory work) from the newly installed facilities in the Substituted Leased Premises; LESSEE
assuming all such risk and waiving any and all claims against LESSOR with respect thereto. If LESSOR is unable to fulfill the conditions set forth above within one hundred twenty (120) days after June 15, 2007, then LESSEE, as its sole and
exclusive remedy at law or in equity shall be entitled to terminate this Amended and Restated Lease Agreement by written notice to LESSOR delivered within ten (10) days of the expiration of said one hundred twenty (120) day period, and
this Amended and Restated Lease Agreement shall be null and void and without recourse to either party, but LESSEE shall be entitled to remain in occupancy of the Current Leased Premises at the rent set forth in this Amended and Restated Lease
Agreement for ninety (90) days after such termination. 
 LESSOR shall be solely responsible for any costs associated with the
architectural and engineering work and permits required for LESSOR’S Work; and LESSOR shall provide such architectural and engineering and permitting services as part of LESSOR’S Work. 

  
 4 

	6.	Security/Guaranty 

 The LESSEE’S
obligations to post and maintain a Security Deposit under Section 5 of the original Lease shall also be required during the Extended Term. 
  

	7.	Parking 

 The provisions of
Section 16 of the Lease shall continue to govern LESSEE’S parking rights and LESSEE shall be entitled to the same number of spaces set forth therein. LESSEE acknowledges that the current rate for such parking spaces is $ 210.00 per
space per month. However, notwithstanding the provisions of Section 16 of the Lease, LESSOR shall determine from time to time in its discretion the extent to which spaces are provided in the LESSOR’S Building or at 808 Memorial Drive
(provided all the spaces contemplated in said Section 16 are provided from one location or the other, with a minimum of fifteen (15) to be provided at 840 Memorial Drive). 

 

	8.	Brokers Commissions/Indemnification 

LESSOR has retained Meredith & Grew, and LESSEE has had some dealings with said brokerage firm, relative to the Building. The LESSOR and LESSEE
each represent to the other that they have not dealt, directly or indirectly, with any other broker, or other entity or individual entitled to any commission relative to the Substituted Leased Premises leased to LESSEE for the Extended Term
hereunder. Each party agrees to indemnify and hold harmless the other from and against any claims for commission arising out the execution and delivery of this agreement and any renewals, extensions or expansions hereof other than the foregoing;
LESSOR expressly agreeing that it shall be responsible for any claims made by Meredith & Grew relative to this transaction, based on separate agreement between LESSOR and Meredith & Grew. 

 

	9.	Assignment/Subletting 

 The LESSEE shall
have the right to assign the Lease and/or sublet the Leased Premises (in whole or in part) subject to all the terms and conditions of Section 12 of the Original Lease. 

 

	10.	Integration of Documents; Supremacy 

 The
parties hereto intend that this Amended and Restated Lease Agreement incorporate the provisions of the original Lease (to the extent not specifically superseded by the terms and conditions hereof) and that conjunctively these documents constitute
the full and complete agreement as between the parties. 
 The following provisions of the Original Lease are not applicable to the Extended
Term: Section 1 (Term); Section 2 (to the extent of the Schedule of Annual Base Rent); Section 3 (as to the first through fourth paragraphs, only); Section 4 (as to the first, and second, and fourth paragraphs, only);
Section 22 (solely to the extent that the notice addresses appearing on the execution pages hereof supersede); Section 33 (which is wholly superseded by Section 5 hereof); and Exhibit B (which is wholly superseded by Exhibit B as it
is attached hereto). 

  
 5 

 As a condition to the effectiveness of this Agreement, LESSOR shall provide to LESSEE either (a) the
written acknowledgement of the current mortgagee that the existing Subordination, Non-Disturbance and Attornment Agreement non-disturbance agreement remains in effect and applies to this Amended and Restated Lease Agreement or (b) a new
Subordination, Non-Disturbance and Attornment Agreement in the form attached hereto in favor of LESSEE executed by the current mortgagee with respect to this Amended and Restated Lease Agreement. 

This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable shall be severable, and the
remainder of this Agreement shall be enforceable in accordance with its terms. This Agreement may only be modified m writing, signed by both parties. Unless otherwise provided herein, all capitalized terms used herein shall have the same meaning as
set forth in the Original Lease. 
 Witness our hands and seals the first date above written. 

 

	
	 RIVERTECH ASSOCIATES II, LLC
  

By Rivertech Associates, Inc. its duly authorized Manager

	
	/s/ Robert Epstein
	Robert Epstein, President

  

							
	Notice Address:	  	 575 Boylston Street 8th Floor

Boston, Massachusetts 02116
	  		  	
	with a copy to:  	  	Christopher C. Tsouros, Esq. Posternak Blankstein & Lund LLP
Prudential Tower
800 Boylston Street Boston, Massachusetts 02199	  		  	

  

			
	GENET1X PHARMACEUTICALS, INC.
		
	By:	 	/s/ Alfred E. Slanetz
		 	its duly authorized

 (Attached Secretary/Clerk’s Certificate As To Authority) 

 

							
	Notice Address:	  	800 Memorial Drive 3rd Floor
Cambridge, Mass.	  		  	
	with a copy to:  	  		  		  	

  
 6 

 GENETIX PHARMACEUTICALS, INC. 
 AMENDED AND RESTATED LEASE AGREEMENT 
 REVISED EXHIBIT B 

Operating Expenses 2006 
 840
Memorial Drive—Riverside Technology Center 
  

					
	 DESCRIPTION
	  	PSF	 
	 HEAT
	  	$	0.54	  
	 BUILDING ELECTRIC
	  	$	2.01	  
	 WATER & SEWER
	  	$	0.21	  
	 ELEVATOR MAINTENANCE
	  	$	0.15	  
	 PARKING/CAFE EXPENSE
	  	$	0.26	  
	 RUBBISH REMOVAL
	  	$	0.14	  
	 INSURANCE
	  	$	0.36	  
	 GROUNDS CARE
	  	$	0.27	  
	 LEGAL/ACCT/ADMIN
	  	$	0.11	  
	 JANITORIAL SERVICES
	  	$	0.50	  
	 GENERAL MAINTENANCE
	  	$	1.38	  
	 HVAC MAINTENANCE
	  	$	0.50	  
	 LIFE SAFETY SYSTEMS
	  	$	0.11	  
	 MANAGEMENT
	  	$	3.28	  
		  	  
	  
	 
	 Total Operating Expenses
	  	$	9.82	  
		  	  
	  
	 
	 Real Estate Taxes (FY 2007)
	  	$	4.63	  
		  	  
	  
	 

 Note: Actual numbers for 2007 and all subsequent years will vary based on actual costs and expenses incurred. 

  
 7 

  
 THE ABBEY GROUP 
  

 
 Genetix Pharmaceuticals 

Relocation to Floor Three, 840 Memorial Drive Revised 5/1/2007 
 Scope of Work by Landlord 
 Office Area 

 

	•	 	 All walls to be repainted 

  

	•	 	 Existing lights to be relamped as required 

  

	•	 	 Space to be cleaned and prepared for occupancy 

  

	•	 	 Existing benchtop in support area to be relocated to 3 perimeter offices which presently do not have benchtops. 

Laboratory Area 

Physical 
  

	•	 	 Repaint all walls 

  

	•	 	 Vinyl tile floor in main labs and in all non-office areas where seamless tile does not exist. 

 

	•	 	 New seamless vinyl floor in BL-2A Lab, BL-2B Lab & autoclave/glasswashing room. 

 

	•	 	 New ceiling and lights throughout lab area. 

  

	•	 	 Provide existing laboratory cabinets with new bench tops as indicated in the “Floor Plan Exhibit”. 

 

	•	 	 Provide 10 foot long single tier reagent shelving above three benchtops in “Biology Lab A” 

Mechanical 
  

	•	 	 Assure proper operation of l0ton supplemental air conditioning supplying main Biology Labs A&B 

 

	•	 	 Assure proper operation of air conditioning units, humidification and dehumidification system in both BL-2 labs. 

 

	•	 	 Assure proper operation of cold room. 

  

	•	 	 Assure proper operation of supplemental air conditioning in equipment room. 

 

	•	 	 Provide adequate exhaust air for Tenant’s (three) six foot hoods, BL2 exhaust hood, BL2 Lab sinks, chemical storage room and autoclave.

 Plumbing 
  

	•	 	 Provide separate water supply with approved backflow prevention devices and a hot water tank in or near the location indicated in the “Floor Plan
Exhibit”. 

  

	•	 	 Provide drain connection from all sinks to a new acid neutralization system (location to be determined), 

 

	•	 	 Provide 7 sinks as indicated in plans with eyewash stations. Controls in each of the two BL-2 Labs to be infrared or foot pedal type.

  

	•	 	 Provide emergency showers in each BL 2 lab. 

  

	•	 	 Provide connection of Tenant’s glasswasher to cold water, drain - 

  
 8 

	•	 	 Provide connection of Tenant’s vacuum and air compressor to existing vacuum and air lines. 

 

	•	 	 Provide connection of Tenant’s “gas tanks” to Tenant’s equipment in the two BL-2 labs. 

 

	•	 	 Connect Tenant’s ice machine to cold water and indirect drain. 

Electrical 
  

	•	 	 Provide separate electric service to the premises including submetering of all equipment. 

 

	•	 	 Provide electric outlets on the three reagent shelving in Lab “A”. 

 

	•	 	 Relocate, Provide power for and install the following Tenant’s equipment: 

Lab Services Area: 
 glasswasher. 
 Biology Lab “A”  

-20 chest freezer, -20 Revco freezer, -20 Bench freezer, incubator 37°, Sorvall centrifuge, ultracentrifuge, shaker & ice
machine. 
 BL-2A Lab equipment - 

(1) six foot hood, co2 Nuaire Incubator, co2 Thermo incubator, refrigerator. 

BL-2B Lab equipment - 
 (2) six foot hoods, co2 stack incubator, GS-6K centrifuge, refrigerator. 
  

			
	 •           NOTE:
	  	Emergency power has, in the past, been taken from the building life safety system which is inconsistent with established building policy and must be remedied by the Tenant’s
installation of a separate emergency generator, most likely on the second floor roof proximate to both the leased premises and a natural gas supply. The Landlord shall assist the tenant by requesting the “building electrician” to provide
Tenant a quote for the appropriate work.

 Telecommunications 

 

	•	 	 Landlord shall provide consultant to assist Tenant in the relocation of or purchase of new telecommunications system or but Landlord shall not be
responsible for cost of either consultation or work associated with IT or telecommunications. 

 Relocation
of Equipment 
  

	•	 	 The landlord shall arrange the move and reconnection of Tenant’s large laboratory equipment as specified in equipment list above to the third
floor leased premises. 

  
 9 

  
 

 

  
 10 

 RIVERSIDE TECHNOLOGY CENTER 

LEASE EXTENSION AND MODIFICATION AGREEMENT 
 TO THE LEASE BETWEEN 
 RIVERTECH ASSOCIATES II LLC AND GENETIX
PHARMACEUTICALS, INC. 
 This Lease Extension and Modification Agreement entered into this 24th day of November, 2009
by and between Rivertech Associates II LLC, a Massachusetts limited liability company with a principal address c/o The Abbey Group, 575 Boylston Street Boston, Massachusetts 02116, (the “Lessor”); and Genetix
Pharmaceuticals, Inc., with a business address at 840 Memorial Drive Cambridge, Massachusetts (the “Lessee”); relative to a certain Lease between Lessor’s predecessor (Rivertech Associates LLC) and Lessee dated
February 18, 2000 referred to herein as the “Original Lease” as amended by a certain Amended and Restated Lease Agreement dated May 18, 2007 (the “Lease Amendment”) for certain office and laboratory space
in the building at 840 Memorial Drive Cambridge, Massachusetts currently consisting of 10,500 rentable square feet of space on the third (3rd) floor of the Building (the “Leased Premises”). The Original Lease, as amended by the Amended
and Restated Lease Agreement, shall be referred to herein as the “Amended Lease”. 
 WHEREAS, the Lessee desires to
extend the Term of the Amended Lease, which is to expire on May 31, 2010, on terms and conditions agreeable to both Lessor and Lessee as a further modification to the Amended Lease, and Lessor assents to such extension of the Term by the Lessee
on this basis; 
 THEREFORE, in consideration of One ($1.00) Dollar and the other good and valuable consideration recited herein,
effective and irrevocable as of the date hereof, the Lessor and Lessee hereby agree as follows: 
  

	1.	Modification to Original Lease/Extension of Term 

 Lessee agrees to lease the Leased Premises commencing as of June 1, 2010 for an additional period of twelve (12) months, beginning June 1, 2010 (the “Extension Commencement
Date”) and ending on May 31, 2011 (the “Termination Date”); which additional period shall be referred to as the “Extended Term” or “Term”. 

Notwithstanding the commencement of the Extended Term on the Extension Commencement Date hereunder, this Lease Extension is to be considered a valid and
binding obligation of the parties effective as of the date of execution, with the Amended Lease to continue to govern the Lessee’s use and occupancy of the Leased Premises hereunder through the Term under the Amended Lease and up to the
Extension Commencement Date hereunder. Thereafter, the Amended Lease (including amendment by this Lease Extension and Modification Agreement) shall conjunctively be and shall be referred to as the “Lease” as between the parties for
the Extended Term. 

  

	2.	Terms And Conditions 

 Lessee shall lease
the Leased Premises commencing as of the Extension Commencement Date on the same terms and conditions of the Amended Lease, as modified by this Lease Extension and Modification Agreement, with exception only for those provisions as to which Lessor
and Lessee have already performed their obligations as of the date hereof, (for example, Lessor has heretofore delivered the Leased Premises and Lessee has accepted the same). 

 

	3.	Base Rent and Additional Rent 

 Base Rent
for each month of the Extended Term shall be Thirty Seven Thousand Six Hundred Twenty Five ($ 37,625.00) Dollars per month, totaling Four Hundred Fifty One Thousand Five Hundred ($ 451,500.00) Dollars for the twelve (12) month extension period.

 In all instances Base Rent shall be payable in the corresponding monthly installments set forth above, due on the first of each month, in
advance, and in all other respects shall be subject to the same provisions relating to Base Rent as set forth under the Original Lease. 
 In
addition to Base Rent, Lessee shall continue to be responsible to pay all Additional Rent as set forth in Section 4 of the Amended Lease, consisting of Operating Expenses under Section 4A and Tax Expenses under Section 4B and
Utilities under Section 4C of the Amended Lease; and all conditions thereunder are hereby restated and affirmed and shall govern the use and occupancy of the Leased Premises throughout the Extended Term. 

 

	4.	Leased Premises in “AS/IS” Condition—No Defaults 

 Lessee hereby acknowledges it is currently in possession of the Leased Premises and accordingly accepts the same for the Extended Term in its current “AS/IS” condition, without representation or
warranty of any kind or nature arising from the extension of the Lease by Lessor and Lessee. 
 Lessor and Lessee each acknowledge that to the
best of each of their respective knowledge, there are no material defaults by either presently existing under the Lease. 
  

	5.	Brokers 

 The parties hereby agree there
are no brokerage or other third party fees or costs involved in this transaction and each agrees to indemnify, defend and hold harmless the other from and against any claims for brokerage fees, commissions or other such payments arising from this
transaction. 
  

	6.	Integration Of Documents: Supremacy 

 The
parties hereto intend that this Lease Extension and Modification Agreement operates to amend and modify the Amended Lease, and that those two documents shall be interpreted conjunctively; with any express conflict between the two to be resolved in
favor of the stated terms of this Lease Extension and Modification Agreement. Except as modified hereby, all other terms and conditions of the Amended Lease shall remain unchanged and enforceable in a manner consistent with this Lease Extension And
Modification Agreement. 

  
 2 

 This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed
unenforceable shall be severable, and the remainder of this Lease Extension and Modification Agreement and the Original Lease shall be enforceable in accordance with their terms. 
 Witness our hands and seals as of the date first written above. 
  

			
	 LESSOR
  

RIVERTECH ASSOCIATES II, LLC

		
	By:	 	/s/ Robert Epstein
		 	its duly authorized Manager

  

			
	 LESSEE
  

GENETIX PHARMACEUTICALS, INC.

		
	By:	 	/s/ Alfred E. Slanetz
		 	its duly authorized President/Vice President

  

			
	By:	 	Illegible Signature
		 	its duly authorized Treasurer/Ass’t Treasurer

  
 3 

 RIVERSIDE TECHNOLOGY CENTER 

SECOND LEASE EXTENSION AND MODIFICATION AGREEMENT 
 TO THE LEASE BETWEEN 
 RIVERTECH ASSOCIATES II LLC AND BLUEBIRD BIO, INC.

 This Second Lease Extension and Modification Agreement (the “Second Lease Extension Agreement”)
entered into this 12th day of September, 2012 by and
between Rivertech Associates II LLC, a Massachusetts limited liability company with a principal address c/o The Abbey Group, 575 Boylston Street Boston, Massachusetts 02116 (successor in interest as stated below, herein, the
“Lessor”), and Bluebird Bio, Inc., with a business address at 840 Memorial Drive Cambridge, Massachusetts (successor in interest as stated below, herein the “Lessee”), with respect to a certain Lease dated
February IS, 2000 (as amended, as stated below) for certain office space in the building at 840 Memorial Drive Cambridge, Massachusetts. 

WHEREAS, Rivertech Associates, LLC and Genetix Pharmaceuticals, Inc. entered into a certain lease agreement dated February 18, 2000 (the
“Original Lease”); and, 
 WHEREAS, Rivertech Associates, LLC and Genetix Pharmaceuticals, Inc. entered into a certain Amended
and Restated Lease Agreement dated May 18, 2007 (the “First Amended Lease Agreement”); and, 
 WHEREAS, Rivertech
Associates II, LLC (as successor in interest to Rivertech Associates, LLC, the original signatory as Lessor under the Original Lease and First Amended Lease Agreement), and Genetix Pharmaceuticals, Inc., entered into a certain Lease Extension and
Modification Agreement dated November 24, 2009 (the “First Lease Extension Agreement”); and, 
 WHEREAS, Rivertech
Associates II, LLC and Bluebird Bio, Inc. (a Delaware corporation, formerly known as Genetix Pharmaceuticals, Inc.), entered into a certain Second Amended and Restated Lease Agreement dated October 19, 2010 (the “Second Amended Lease
Agreement”); collectively, the Original Lease as amended and modified by the foregoing First Amended Lease Agreement, Lease Extension Agreement, and Second Amended Lease Agreement being referred to herein as the “Existing
Lease”; and, 
 WHEREAS, the current Term under the Existing Lease expires on November 30, 2014 (the “Current
Term”), and the Lessee seeks to extend the Current Term so as to expire on March 31, 2015, which date is referred to herein as the “Extended Term Termination Date”, and which entire term period as extended is referred
to herein as the “Extended Term”; and, 
 WHEREAS, under the Existing Lease the Lessee leases and occupies
approximately 9,488 rentable square feet of space located on the fourth (4th) floor of the Building, in addition to approximately fifty (50) rentable square feet of space on the third (3rd) floor of the Building, for a total of approximately 9,538 rentable square feet of space in the Building,
collectively known under the Existing Lease as the New Leased Premises and referred to herein as the “Existing Premises”; and, 

 
WHEREAS, by this Second Lease Extension Agreement Lessee seeks to add approximately 8,060 rentable square feet of space located on the fourth (4th) floor of the Building, in addition to approximately fifty
(50) rentable square feet of space on the third
(3rd) floor of the Building, for a total of
approximately 8,110 rentable square feet in the Building, as shown on Exhibit A hereto and collectively known as the “Expansion Space”; which, when added to the Existing Premises is collectively referred to herein as the
“Total Leased Premises”; and, 
 WHEREAS, Rivertech Associates II, LLC and Bluebird Bio, Inc., seek by this current agreement
to further amend and modify the Existing Lease to farther extend the Current Term of the Existing Lease, and to lease the Expansion Space, as set forth in detail below and under the terms and conditions of the Existing Lease as it is amended and
modified hereby; 
 THEREFORE, in consideration of One ($1.00) Dollar and the other good and valuable consideration recited herein,
effective and irrevocable as of the date hereof, the Lessor and Lessee hereby agree as follows: 
  

	1.	Modification to Existing Lease / Extension of Current Term 

 The Existing Lease expires on November 31, 2014 at the end of the Current Term. Lessee agrees to extend its tenancy as to the Existing Premises, commencing as of the end of the Current Term under the
Existing Lease (i.e. from November 31, 2014), for an additional four (4) month period beginning on December 1, 2014 (the “Extension Commencement Date”) and ending on March 31, 2015 (the ‘Termination
Date”); which additional period shall be referred to as the “Extended Term” or “Term”. Further, from the Expansion Space Delivery Dates (as defined herein) through the end of the Extended Term, Lessee also
agrees to lease the Expansion Space (as defined herein) on the terms and conditions set forth herein. 
 Notwithstanding the commencement of the
Extended Term on the Extension Commencement Date hereunder, this Lease Extension is to be considered a valid and binding obligation of the parties effective as of the date of execution of this Second Lease Extension Agreement by the parties and its
approval by Lessor’s lender (which approval is an express condition to the extension and expansion contemplated herein and which Lessor shall seek immediately upon execution of this Agreement by both parties); with the Existing Lease to
continue to govern the Lessee’s use and occupancy of the Existing Premises hereunder through the Term and up to the Extension Commencement Date hereunder, subject to the supplemental provisions hereof relating to the Expansion Space (defined
herein). Lessee agrees to execute the Landlord’s lender’s standard Subordination Non-Disturbance and Attornment Agreement upon execution of this Second Lease Extension Agreement and Lessor agrees to promptly use commercially reasonable
efforts to seek its lender’s execution of the same, but without any obligation to actually deliver the same to Lessee and without any material impact on this Second Lease Extension Agreement or the underlying Existing Lease upon any failure to
do so. 
  

	2.	Terms and Conditions 

 Lessee shall lease
the Total Leased Premises (with the addition of the Expansion Space to be leased as of the Expansion Space Delivery Date) on the same terms and conditions of the Existing Lease, as modified by this Second Lease Extension Agreement, with exception
only for 

  
 2 

 
those provisions as to which Lessor and Lessee have already performed their obligations as of the date hereof, (for example, Lessor has heretofore delivered the Existing Premises and Lessee has
accepted the same). The Existing Premises is leased in the same “AS/IS’1 condition as it is as of the execution of this Second Lease Extension Agreement, and Lessee acknowledges Lessor is under no obligation to make any improvements or
modifications thereto, in any manner. 
  

	3.	Expansion Space Added to the Existing Premises 

 Lessor shall deliver the Expansion Space to Lessee (to be added to and, in the aggregate, to constitute the Total Leased Premises). The Expansion Space shall be delivered to the Lessee upon Substantial
Completion (as defined below) of Lessor’s Work (as defined herein below) on the office portion of the Expansion Space (the “Office Expansion Space”) and on the laboratory portion of the Expansion Space (the “Lab
Expansion Space”), herein, the “Office Expansion Delivery Date” and the “Lab Expansion Delivery Date” respectively, and also referred to herein collectively as the “Expansion Delivery
Dates”. As of the respective Expansion Delivery Dates, the Office Expansion Space and the Lab Expansion Space, respectively, shall be Substantially Complete, vacated by any current tenants and occupants; with Lessor’s Work having been
performed in a good and workmanlike manner according to Lessor’s Scope of Work; broom clean. All Lessee’s Rent payments and other Lease obligations relating to the Expansion Space shall commence as of the Expansion Space Office Delivery
Date and the Expansion Space Lab Delivery Date, respectively. All terms and conditions of the Lease shall govern the Lessee’s use and occupancy of the Expansion Space as of the respective Expansion Space Delivery Dates. 

Lessor’s delivery of the Office Expansion Space and the Lab Expansion Space shall be evidenced in each instance by a written notice of delivery
(“Lessor’s Delivery Notice”) given to Lessee on the actual date the respective portion of the Expansion Space is Substantially Complete and provided to Lessee for its occupancy. Lessee shall have five (5) business days to
contest delivery if the Expansion Space is not Substantially Complete or it does not conform with the Lessor’s Scope of Work and Lessor’s Work by delivering its notice thereof in writing to Lessor; however, any listed items of a
“punchlist” nature shall be agreed to by Lessor and Lessee and shall not be grounds to contest delivery, but nevertheless shall obligate Lessor to complete such punchlist items at the earliest practicable time under the circumstances.

 The following conditions to the delivery of the Office Expansion Space and the Lab Expansion Space to the Lessee by the Lessor shall be met
by the Lessor, at its sole cost and expense, prior to the respective Expansion Delivery Dates. The Lessor shall perform, at its sole cost and expense, such design and construction work as is necessary to deliver the respective portions of the
Expansion Space to the Lessee in accord with the “Scope of Landlord’s Work for Additional Premises Only” dated August 13, 2012 attached hereto as Exhibit A (the Exhibit referred to as the “Lessor’s Scope of
Work” and the design and construction obligations thereunder being referred to as the “Lessor’s Work”). All components of Lessor’s Work will be completed in accordance with all applicable laws, rules and
regulations, including but not limited to the latest requirements of NFPA, ANSI Standards, ASHRAE Standards, National Electrical Code, Massachusetts State Building Code, and regulations of the City of Cambridge. Lessor shall deliver the Expansion
Space with the base Building systems serving the same and with Lessee’s specific mechanical, electrical and plumbing systems as required in Lessor’s Scope of Work (i.e. Exhibit A hereto), in good operating condition and repair, and
suitable for their intended uses. 

  
 3 

 
All utilities for the Expansion Space shall be in place and separately metered. The Building and the Expansion Space as delivered to the Lessee will be compliant with the Americans with
Disabilities Act; NFPA compliant pursuant to the Massachusetts State Building Code; and with code compliant demising walls and common area corridors. Lessor shall provide Lessee with the environmental close-out report prepared by the former tenant
for the Expansion Space, and said report shall not disclose any conditions as would materially impair Lessee’s use of the Expansion Space. Subject to the foregoing, Lessor shall not be responsible for any other design or construction work with
respect to either the Existing Premises under the Existing Lease, or the Expansion Space. 
 To the extent Lessee seeks to make any changes to
the Lessor’s Scope of Work as set forth on Exhibit A hereto: (i) such changes will be communicated in writing with sufficient specificity for Lessor to price the changes; (ii) Lessor will provide Lessee with pricing as to such changes
and any estimated delays, if any, that may result for such changes; and (iii) in the event such changes affect the total cost of the Lessor’s Scope of Work, Lessee shall either reimburse Lessor in advance for any increased costs and
expenses, or Lessor shall credit Lessee for any savings against Lessee’s next due payments of Rent hereunder. Upon receiving from Lessor the estimated cost and timing impacts of Lessee’s proposed changes pursuant to subsection
(ii) above, Lessee may choose to not move forward with such proposed changes provided it communicates its final intention to the Lessor in writing within ten (10) days of its receipt of Lessor’s cost and timing impacts. Lessee shall
be solely responsible for any delays in the completion of Lessor’s Work arising from any such requested changes. 
 The Lessee shall be
solely responsible, at its sole cost and expense, to perform such other specific design and construction work on the Expansion Space as it desires for its use and occupancy (“Lessee’s Work”), upon completion of the
Lessor’s Work in the respective office and laboratory portions of the Expansion Space, and delivery of those respective portions the Expansion Space by the Lessor. Lessee shall be provided with access to the Expansion Space commencing upon
execution of this Second Lease Extension Agreement, coordinated through the Lessor, for the purpose of performing preliminary work toward the installation of its equipment and wiring, provided such access and preliminary work does not materially
interfere with Lessor’s ability to perform and complete its Lessor’s Work, which shall take precedence in all respects. Lessee’s Work and all subsequent Lessee alterations to the Leased Premises that are performed by Lessee on or
affecting the fire, life safety and/or sprinkler systems of the building shall be made in such a manner and under such conditions as to pose no adverse impact or interruption to such fire, life safety, and sprinkler systems, and so as not to delay,
impair, or jeopardize the legal occupancy of other tenants in the Building as determined by Lessor and municipal fire and building inspection officials. 
 The Lessor’s Work as to the Office Expansion Space and the Lab Expansion Space, separately, will be deemed “Substantially Complete” as to each: (a) when Lessor’s Work is
substantially complete in accordance with Lessor’s Scope of Work as set forth in Exhibit A and the provisions of this Section 3, except for minor punch list items approved by Lessee that will not materially adversely affect
Tenant’s normal operations in said Expansion Space; Lessor’s Work therein having been performed in a good and workmanlike manner with all necessary municipal approvals for occupancy. 

  
 4 

	4.	Annual Base Rent and Additional Rent 

Annual Base Rent from the date of execution of this Second Lease Extension Agreement through the Extended Term, shall be as set forth below: 

 

	A.	Annual Base Rent as applied to the Existing Premises 

 (i.e. 9,538 rentable square feet of space) 
  

	 	(i)	Balance of the Current Term                 As set forth in the Existing Lease

  

	 	(ii)	Extension Commencement Date            $ 145,136.57 ($ 36,284.14 / mo.) 

through the Termination Date 
  

	B.	Annual Base Rent as applied to the Expansion Space (i.e. 8,110 rentable square feet of space) 

 

	 	(i)	Expansion Space Staggered Delivery Periods—Interim Rent/Per Diem 

 Lessor’s estimated delivery of the Office Expansion Space is targeted to October 1, 2012. Lessor’s estimated delivery of the Lab Expansion Space is targeted to December 1, 2012. The
first day of the calendar month following the day on which the Office Expansion Delivery Date occurs is referred to herein as the “Expansion Rent Start Date”). A per diem calculation is required to determine interim Rent obligations
occurring upon delivery of the respective Office Expansion Space and Lab Expansion Space. Annual Base Rent for the total Expansion Space (office and laboratory) for the first full twelve month period following the Expansion Rent Start Date is
$395,362.50 ($32,946.88 on a monthly basis). This computes to $1,083.18 on a per diem basis. The per diem amount allocated to the Office Expansion Space is $496.42, (i.e. 45.83% at 3,717 rentable square feet of a total 8,110 rentable square feet),
the “Office Per Diem”. The per diem amount allocated to the Lab Expansion Space is $586.76 (i.e. 54.17% at 4,393 rentable square feet of a total 8,110 rentable square feet), the “Lab Per Diem”. 

(x) For the interim period between the Office Expansion Delivery Date and the Expansion Rent Start Date, the Annual Base Rent payment
attributable to the Office Expansion Space shall be determined by taking the number of days from the Office Expansion Delivery Date through the Expansion Rent Start Date and multiplying by $496.42. This amount shall be paid to Lessor.

 (y) For the interim period between the Lab Expansion Delivery Date and the Expansion Rent Start Date (given the possibility
the Expansion Rent Start Date may not have occurred due to delays in delivery of the Office Expansion Space),the Annual Base Rent payment attributable to the Lab Expansion Space shall be determined by taking the number of days from the Lab Expansion
Delivery Date through the Expansion Rent Start Date (if applicable) and multiplying by $586.76. This amount (if applicable) shall be paid to Lessor. 

  
 5 

	 	(ii)	Annual Base Rent due from the Expansion Rent Start Date through the next twelve (12) consecutive months is: 

$ 395,362.50 ($ 32,946.88 /mo.)* 
 *[less the Lab Per Diem for each day in such period that the Lab Expansion Space is not delivered] 
  

	 	(iii)	Annual Base Rent due through the next twelve (12) consecutive months (after (ii) above) is: 

$ 405,500.00 ($ 33,791.60/mo.) 
  

	 	(iv)	Annual Base Rent due through the next consecutive months (after (iii) above) to the end of the Extended Term is: 

$ variable ($ 34,636.46 / mo.) 
 In all instances under A and B above, Annual Base Rent shall be payable in the corresponding monthly installments set forth above, due on the first of each month, in advance, and in all other respects
shall be subject to the provisions relating to Annual Base Rent as set forth under the Existing Lease. 
  

	C.	Additional Rent. 

 In addition to Annual
Base Rent, Lessee shall continue to be responsible to pay all Additional Rent (Operating Expenses) under Section 3 of the Existing Lease, and all Additional Rent (Taxes) under Section 4 thereof, as applicable to both the Existing Premises
and the Expansion Space, as invoiced by Lessor during the Extended Term. A current statement outlining the Operating Expenses incurred for the Building in 2011 is attached hereto as Exhibit B. 

As the concept is used in the Lease to compute Additional Rent, Lessee’s allocable pro rata share (“Allocable Percentage”) shall be
as follows: 
  

	(A)	Allocable Percentage for the Existing Premises running through the end of the Term, shall be 7.4 %. 

 

	(B)	Allocable Percentage for the Expansion Space, starting on the Expansion Space Delivery Dates and running through the end of the Term, shall be 6.29 %.

 To the extent that the Expansion Space Commencement Dates do not fall on the first calendar day of a month, then
the first month in which the Expansion Space Commencement Dates occur will have Additional Rent attributable to the Expansion Space prorated on a per diem basis for that month. 

  
 6 

	D.	Rent and other Costs and Expenses. 

 All
Annual Base Rent, Additional Rent and other sums due as Rent shall be payable and in all other respects shall be governed during the remainder of the Current Term, and for the Extended Term, as contemplated under the Existing Lease, except to the
extent modified and supplemented above. All other costs and expenses for utilities and services and attendant to operation of the Total Leased Premises (i.e. as applicable to both the Existing Premises, and to the Expansion Space as of the
respective Expansion Space Delivery Dates), shall be borne by the respective parties as set forth in the Existing Lease. 
  

	E.	Security Deposit. 

 The Security Deposit
currently held by the Lessor shall continue to be held by Lessor during the Extended Term. 
  

	5.	Permitted Uses 

 The Permitted Uses for
the Total Leases Premises shall be office, R&D and laboratory use in conformity with all federal, state, municipal and local laws, codes, ordinances, rules and regulations of governmental authorities, committees, associations, or other
regulatory committees, agencies or governing bodies having jurisdiction over the Total Leased Premises, and in conformity with the conditions and restrictions set forth in the Original Lease (which are hereby restated and affirmed by Lessee).

  

	6.	Existing Premises in “AS/IS” Condition—No Defaults 

 Lessee hereby acknowledges it is currently in possession of the Existing Premises and accordingly accepts the same from the date of this Second Lease Extension Agreement in its current “AS/IS”
condition, without representation or warranty of any kind or nature arising from the extension of the Lease by Lessor and Lessee. 
 Lessor and
Lessee each acknowledge that to the best of each of their respective knowledge, there are no material defaults by either presently existing under the Lease. 
  

	7.	Brokers 

 The parties hereby agree there
are no brokerage or other third party fees or costs involved in this transaction and each agrees to indemnify, defend and hold harmless the other from and against any claims for brokerage fees, commissions or other such payments arising from this
transaction. 
  

	8.	Parking. 

 Lessee shall be granted, at
current rates (which may be increased from time to time to reflect market increases), the right (but not the obligation) to park up to twenty seven (27) cars in total in the Building’s on-site indoor parking lot or facility on an
unassigned and unreserved basis, in single or tandem spaces or on a valet basis which Lessor in its sole discretion shall designate from time to time. The initial parking rate therefor shall be S225 per month, per car, which monthly rate may be
changed by Lessor in its discretion subject to and reflective of periodic 

  
 7 

 
market changes. Additionally, Lessee shall be entitled to rights to park additional cars in the Building garage (but subject to availability as determined by Lessor, and only on a valet basis,
and then only to the extent Lessor is providing valet service to the Building garage which Lessor shall not be obligated to do), at then current rates as set by Lessor in its discretion. If Lessor cannot accommodate Lessee’s needs for
additional parking in the Building garage, then Lessor will assist Lessee in identifying alternative off-site parking, but Lessor shall bear no liability nor shall it be deemed any default under the Lease if such additional Building garage parking
or off-site parking do not materialize. All payments for these parking rights shall be considered to be Additional Rent under this Lease. This provision supersedes any contrary provisions of the Existing Lease and the specific numeric rights set
forth above supplant the numeric rights otherwise set forth in the Existing Lease. 
  

	9.	Lessee’s Option to Extend 

 Provided
Lessee has not defaulted (after applicable notice, grace and cure periods, if any) under the Lease from the date hereof forward more than two (2) times, and further provided no uncured default on the part of Lessee is then existing, Lessee
shall have the option to further extend the Term of this Lease as to the Total Leased Premises (i.e. inclusive of the Expansion Space) on the terms and conditions herein, for one additional period of thirty six (36) months (herein, the
“Additional Term Extension Period”) at the then current “Market Rent” (including annual escalations thereon for each year of the extended term based on increases in the Consumer Price Index or fixed increases, as the case
may be, as determined by then prevailing market forces), but no less than an amount equal to the annualized Rent per rentable square foot of Total Leased Premises space as of the final full month of the last Lease Year hereunder (the
“Extension Rent Floor”). Said Additional Term Extension Period shall commence, subject to proper exercise of Lessee’s option hereunder, at the end of the Extended Term (i.e. at the end of March, 2015) and shall terminate on
that date which is thirty six (36) consecutive months thereafter (i.e. March 31, 2018). Lessee shall exercise its option by delivering to Lessor its written notice not later than ten (10) full months (but not sooner than twelve
(12) full months) prior to the end of the Extended Term. Once delivered, written notice to extend is irrevocable. 
 “Market
Rent” as used herein, shall be that rent charged for comparable research laboratory and office space of similar age and condition in laboratory buildings the mid-Cambridge submarket as of the end of the Extended Term. If, after good faith
attempts prior to the expiration of the original Term, the Lessor and Lessee cannot agree on a figure representing Market Rent, then either party, upon written notice to the other, may request appraisal and arbitration of the issue as provided in
this section. Within fourteen (14) days of the request for arbitration, each party shall submit to the other the name of one unrelated individual or entity with proven expertise in the leasing of commercial real estate in greater
Boston/Cambridge to serve as that party’s appraiser. Each appraiser shall be paid by the party selecting him or it. The two appraisers shall each submit their final reports to the parties within thirty (30) days of their selection making
their determination as to Market Rent (subject however, to the Extension Rent Floor). The two appraisers shall meet within the next fourteen (14) days to reconcile their reports and collaboratively determine the Market Rent. They shall each
make their determination in writing (subject however, to the Extension Rent Floor), including a statement if such is the case, that they are at an impasse. Such a statement of impasse shall be submitted to the parties along with the Market Rent
figure which each appraiser has selected and his reasons and substantiation 

  
 8 

 
therefor. The appraisers, in case of an impasse, shall also agree on one unrelated individual or entity with expertise in commercial real estate in greater Boston, who shall evaluate the reports
of the two original appraisers and within fourteen (14) days of submission of the issue to him, make his own determination as to a figure representing Market Rent (subject however, to the Extension Rent Floor). The determination of this
individual or entity (i.e. arbitrator) absent, fraud, bias or undue prejudice shall be binding upon the parties. 
 Annual Base Rent and
Additional Rent during any Additional Term Extension Period shall be payable in advance, in equal monthly installments on the first day of each calendar month. 
 Lessee, in addition to the sums payable annually to Lessor as Annual Base Rent, shall pay to Lessor for each year of the Additional Term Extension Period, as Additional Rent, Lessee’s Allocable
Percentage (as determined by the approximate total rentable space leased) for Operating Expenses, Real Estate Taxes and utilities as contemplated in Section 4 hereof. 

 

	10.	Access; Elevators; Dumpsters; Signage 

Lessee shall have 24/7 access to the Total Leased Premises (with regard to the Expansion Space, such access shall be allowed following the applicable
Expansion Delivery Dates), the common areas and elevators serving the Total Leases Premises, the freight elevators servicing the Building, the loading docks servicing the Building and the dumpster and/or compactor servicing the Building. 

Lessor shall provide, at Lessor’s expense, building standard signage in the Building’s lobby, in any Building directory, and at the main
entrance to the Total Leased Premises. 
  

	11.	Integration of Documents; Supremacy 

 This
Second Lease Extension Agreement contains the full understanding and agreement between the parties. The parties hereto intend that this Second Lease Extension Agreement operates to amend and modify the Existing Lease, and that those documents shall
be interpreted conjunctively; with any express conflict between the two to be resolved in favor of the stated terms of this Second Lease Extension Agreement. Except as modified hereby, all other terms and conditions of the Existing Lease shall
remain unchanged and enforceable in a manner consistent with this Second Lease Extension Agreement. Defined terms used in this Second Lease Extension Agreement that are not otherwise defined herein shall have the definitions ascribed to such terms
in the Existing Lease. 
 This Agreement shall be governed by the laws of the Commonwealth of Massachusetts. Any provisions deemed unenforceable
shall be severable, and the remainder of this Second Lease Extension Agreement and the Existing Lease shall be enforceable in accordance with their terms. 
 [Signature Pages Follow] 

  
 9 

 Witness our hands and seals as of the date first written above. 

 

			
	 LESSOR
  

RIVERTECH ASSOCIATES II, LLC

		
	By:	 	/s/ Robert Epstein
		 	its duly authorized Manager

  

			
	 LESSEE
  

BLUEBIRD BIO, INC.

		
	By:	 	/s/ Nick Leschly
		 	its duly authorized President/Vice President

  

			
	By:	 	/s/ Jeffrey T. Walsh
		 	its duly authorized Treasurer/Ass’t Treasurer

  
 10 

			
	 BLUEBIRD BIO, INC.

SECOND LEASE EXTENSION
 AND
MODIFICATION AGREEMENT
	  	EXHIBIT A

 See Attached 

			
	 BLUEBIRD BIO

Floor Four
 840 Memorial Drive
 Cambridge, MA
	  	AUGUST 13, 2012

 SCOPE OF LANDLORDS WORK FOR ADDITIONAL PREMISES ONLY 
 *** Space will be emptied of all furnishing prior to move-in date 
 Partitions: Partitions are to
be removed and relocated as indicated on the accompanying plans. Existing and new walls are comprised of gwb over steel studs and extend from floor to the underside of the suspended ceiling. The walls demising the Administrative areas from R&D
areas extend to the underside of the deck above. All walls will be finished with two coats water based paint. The entire office space will have 2 new coats of water based paint to match bluebird’s existing space color scheme. 

Existing “lavatory” room will have plumbing removed and remain as storage room. New storage room will have VCT removed and new matching
carpeting. 
 Glass Panels: Where they exist, glass panels to remain. Glass panels from 4131 and 4130 will be removed to allow for the
respective doors to be relocated. This is to allow for the modern-fold partition to be stored on the wall in between the doors when it is not separating 4131 and 4130. 
 Entry: Existing glass entry to remain. 
 Doors: Existing doors will be reused and relocated as
necessary provided they have existing full lite glazing. All hardware are lever handles with brushed stainless finish. New office doors will be installed with full lite glazing where applicable. All office doors will have full lite glazing. Office
and conference room door hardware will be comprised of passage function latchsets with brushed stainless finish. Storage room latchsets will be comprised of class room function latchsets with brushed stainless finish. 

Floors: All carpeted areas in the administrative which are affected by construction will be re-carpeted with matching Shaw Contract nylon loop carpet
from “Turn Key Collection. 4” vinyl cove base has been installed at intersection of walls and carpet/vct. Vinyl tile installed in the floor of the kitchenette to remain. VCT will be removed from the storage area and be replaced with
matching carpeting, 4” vinyl cove base will be installed in the storage areas as well as areas affected by construction. 
 Ceilings: All
existing ceiling tiles will remain or be replaced as necessary. Any damaged ceiling tiles will be replaced with matching ceiling tiles. Any damage to ceiling grid will be repaired. 
 Lighting: All existing fluorescent lights will remain and be relocated as necessary to accommodate the new configuration. All existing fluorescent lights will be inspected to insure proper functioning and
be repaired or replaced as necessary. 

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

 HVAC: The base building HVAC distribution system will be inspected and adjusted as necessary to assure
distribution, airflow, and proper operation of thermostats and variable air volume (VAV) boxes. There will be a redistribution of the system to accommodate 5 separate zones as indicated on the drawings. This work will be designed by landlord’s
consulting engineer. The office area will be provided with make-up air from either the 30 ton roof mounted MUA unit or house systems in order to provide fresh air to the office and maintain positive pressure with respect to R&D space. A
pre-construction balancing/CFM reading will be done to show existing air balance in the space. The landlord’s engineer will perform HVAC load calculations to take into account insulation, square footage, occupancy and equipment heat loss to
determine heating and cooling loads. Expected equipment and occupant load shall be provided to the landlord’s engineer for this purpose. The space will be balanced according to these calculations. All balancing will be conducted by a NEEB
certified balancing technician. Pre-construction balancing, engineering calculations and post-construction “as built” documentation/balancing reports will be provided to the tenant or the tenant’s designee. The new space will conform
to ASHRAE Standard 55 “Thermal Environmental Conditions for Human Occupancy”. All HVAC equipment shall be inspect by the landlord and replaced as necessary. The lessee accepts the existing HVAC system provided that it is in good working
order, that it conforms to ASHRAE Standard 55, and that a reasonable temperature is maintained in the office areas. In the event during the lease term the HVAC system does not meet the aforementioned prerequisites the landlord will provide a new
system which will be replaced at the Landlord’s cost. The tenant will be responsible for maintaining and repairing all tenant specific supplemental mechanical equipment beyond the 6 month warranty period. Tenant specific mechanical equipment
will be delivered in good operating condition. 
 Kitchenette: The kitchenette will remain undisturbed. 

Electrical: Existing electrical outlets throughout the administration area and the office space in the R&D area in the form of existing and new 1l0v
outlets to remain. All utilities servicing the tenant’s premises and equipment are separately metered and will be read monthly by the landlord for reimbursement by the tenant. New outlets will be installed to accommodate the new layout. Each
office will have a minimum of 3 120/20a 5-20R receptacles. All electrical circuits will be labeled via labels at the outlet, junction box, safety switch, or other corresponding electrical equipment and a corresponding label on the electrical panel
indicating the appropriate circuit breaker. 
 Furnishings: No reception desk cubicles, work stations or furniture of any sort shall be provided
by the landlord. 
 Specialties: A demountable partition by Modernfold or equal will be installed as indicated in the plans. This wall will have
a “Dry Erase” surface from floor to ceiling. BluebirdBio or their designee will have access to the space during the renovation to inspect progress and that the work being done conforms to this scope. 

Fire Protection: Fire protection will be added as needed and required by Massachusetts Building cod, NFPA and local Fire Code. 

Work included in this scope will comply with the Massachusetts Building Code and NFPA. 

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

 R&D AREA  
 Demolition: Existing lab benches, plumbing, piping, vinyl tile, doors and walls required to be removed to accommodate new plan will be removed. The existing 6’ hood shall be capped and removed from
the premises. The existing wing wall adjacent to the hood shall be removed per attached drawings. 
 The entire R&D area will have 2 coats
water based paint applied per Bluebird bio’s existing paint scheme 
 New Partitions: New partitions enclosing new
tissue culture suites shall consist of existing walls comprised of 5/8”gwb over 3  1/2” steel studs and extending from floor to 6” above the underside of the suspended ceiling. Walls and trim will be
finished with two coats water based paint. Paint finish in tissue culture rooms to be semi gloss. 
 The tissue culture rooms will be
separated from the main laboratory by a hallway as indicated in the drawing. 
 Existing glass panels in the exterior offices shall be removed.

 The walls surrounding the “radio-isotope room” shall extend to the underside of the deck above and have an additional layer of
5/8” gwb applied to each accessible side of the wall. Walls will be constructed to the deck above with 2 layers of 5/8” GWB. Walls will be completely sealed with appropriate sealant in order to prevent any contamination of adjoining
spaces. Work will be consistent with attached drawing and keynotes. 
 The existing exterior window in the office to become the darkroom shall
be blacked out via either applied opaque vinyl or an opaque panel which will prevent any light from entering via the window. 
 Doors: Where
indicated on the drawings, Horton Ultra-Clean Series Atmospheric 110 doors with push plate activators and safety scan sensors will be installed. Buttons to activate the doors will be installed. 

A 36” diameter circular darkroom door shall be installed in the office to become the darkroom as indicated on the plans. The door shall fit within a
36” wall opening and have a “pop-out” feature with breakaway hardware for use in emergencies and shall conform to Massachusetts Building Code requirements. 
 Floors: All new tissue culture suite floors will be covered with seamless vinyl with integral vinyl base. Floors where noted in the drawing as indicated by keynotes, to include the radio-isotope room and
hallway, will be covered with seamless vinyl with integral vinyl base. The damaged vinyl floor in the autoclave room will be repaired. 

Ceilings: Except for the tissue culture suite, existing building standard ceiling tiles will remain in the existing grid. In the Tissue Culture Suites,
and as indicated in attached drawing keynotes, to include the radio isotope room and hallway, new solid surface washable ceiling tiles will be installed in the new ceiling grid with vinyl gasketing. Any damaged ceiling tiles will be replaced. Any
damage to ceiling grid will be repaired. 

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

 Lighting: Except for the new Tissue areas, existing 2x4 and 2x2 fluorescent lights will remain. Solid
surface lens type fluorescent lights will be used in the Tissue Culture, radio-isotope, and Glasswash/Autoclave rooms. 
 BENCHES: The three
remaining lab benches with sink will remain. Oak benches with stainless steel sinks and acid resistant plastic laminate tops will be installed in the two new tissue culture suites while the existing bench and sink in the existing tissue culture
suite shall be relocated as indicated on the plans. Oak benches/casework with a stainless steel sink and epoxy resin counter top will be installed in the radio-isotope room in the form of an L-shape as indicated in the attached drawing. The sink in
the radio-isotope room will have a motion activated faucet. The casework and countertop in the radio-isotope room will be designed such that space for a 4’ fume hood or BSC be provided for future installation. Each lab sink will have protected
hot and cold water and deck mounted emergency eyewash stations. 
 HVAC: The base building HVAC distribution system will be inspected and
adjusted as necessary to assure good operating condition and repair, distribution, airflow, and proper operation of thermostats and variable air volume (VAV) boxes. The existing supplemental air conditioning units will be inspected and put in good
operating condition and repair. One of these supplementary systems will service the main laboratory (4114), the second will service the existing tissue culture suite 4118. The third existing unit will service the new tissue culture suite
(4119) or suite’s (4119 and 4120) depending on HVAC load requirements. If necessary a new unit with integral electric heat will serve the tissue culture suite (4120). The air conditioning units should correspond to what HVAC heating and
cooling is required, as indicated by analysis conducted by the landlord’s engineer. All tenant specific mechanical systems shall be warranted for proper operation for a period of six months provided tenant enters into an appropriate preventive
maintenance agreement for this equipment as stated below. Tenant specific mechanical equipment will be delivered in good operating condition. A pre-construction balancing/cfm reading will be done to show existing air balance in the space. The
landlord’s engineer will perform load calculations to take into account insulation, square footage, occupancy and equipment heat loss to determine heating and cooling loads. Expected equipment and occupant load shall be provided to the
landlord’s engineer for analysis and design of the HVAC system. The space will be balanced according to these calculations. All balancing will be conducted by a NEED certified balancing technician. Pre-construction balancing, engineering
calculations and post-construction “as built” documentation/balancing reports will be provided to the tenant or the tenant’s designee. The new space will conform to ASHRAE 55 “Thermal Environmental Conditions for Human
Occupancy” and ASHRAE Standard 62.1 2010 “Ventilation for Acceptable Indoor Air Quality”. All HVAC equipment shall be inspected by the landlord and replaced as necessary to ensure good operating condition and repair. The lessee
accepts the existing HVAC system provided that it is in good working order, that it conforms to ASHRAE Standard 55, and 62.1 2010, and that a reasonable temperature is maintained in the R&D areas. In the event during the lease term the HVAC
system does not meet the aforementioned prerequisites the landlord will provide a new system which will be at the Landlord’s cost. Tissue culture spaces will have 6 to 15 air changes per hour. Spaces will be pressurized according to the
attached drawing. 

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

 The fume hood which is to remain in the laboratory is connected to a roof mounted exhaust fan and shall be
air balanced to assure a minimum of 100 FPM airflow across the sash at an 18” sash opening. Fume hood will be equipped with a flow monitoring device which will indicate high/low limits. The remaining approximately 800cfm of exhaust shall be
connected to ceiling grilles in the main lab and shall exhaust the lab. If more CFM is required to exhaust the lab according to the attached pressurization drawing it will be provided at the Landlord’s expense. Exhaust must create negative
pressure in the hallway connecting the tissue culture suites as well as create a negative with regard the office and main lab. The landlord’s engineer will make the necessary calculations and resulting balancing recommendations to ensure that
the space is pressurized accordingly. Make up air shall be provided from a 30 ton roof mounted make-up air unit and shall be fed to each of the three tissue culture suites (4118, 4119, and 4120) and the “radio-isotope room” (4116). Make up
air shall also be provided to the main lab space (4114). All air supplied to each of the tissue culture suites shall be via 95% HEPA filters with 30% pre-filters on each of the ac units, MUA units, feeding, the spaces. Each tissue culture suite
shall have a pressure relief exhaust grill installed on a wall adjacent to the main lab. The tenant will be responsible for maintaining and repairing all tenant specific supplemental mechanical equipment beyond the 6 month warranty period.

 The Lab/Office will be pressurized as indicated in the attached drawing. Room for a 4’ wide fume hood or ducted BSC will be left in the
Radio-Isotope Room. The cost of operating and maintaining both exhaust fan and make up air unit shall be a tenant expense. All Tenant-specific mechanical equipment shall be put on a preventive maintenance agreement by the tenant and at Tenant’s
expense for the duration of the Lease. 
 Plumbing and Waste: The main cold water supply to the lab is located in the “Lab support”
room which also contains a hot water heater, a water check meter and a backflow prevention device. All lab waste is contained in polyethylene piping and leads to an acid waste system consisting of a tank with limestone chips located in an accessible
location on the third floor directly below the premises. Lab waste and holding within the “isotope room” will be connected to the existing laboratory waste system. Before the room is used for radio-isotopes this drain will be disconnected
and is subject to future engineering and installation by the tenant. Future modifications to this drain is not subject to this scope of work. The laboratory wastewater system will be maintained by the tenant who shall also be responsible for
required municipal discharge permits, sampling and testing. 
 Safety Showers will be added in rooms 4116 4119 and 4120 and will meet or exceed
ANSI standards. Requirements for safety showers and eyewash stations throughout the lab space will be accessed by the landlord and will also be made to comply with ANSI standards. 
 Autoclave Room: The landlord has provided a room in which an autoclave can be installed. Actual equipment will be provided by the tenant. The existing laboratory sink with protected hot and cold water and
eyewash shall remain. The seamless vinyl floor with integral base shall be repaired as required. Electrical hot water, drain will be installed to accommodate the future installation of a dishwasher. 

Electrical: Power to various locations within the laboratory exists in the form of existing 110v and 208v outlets. 12 additional 120v/20A circuits, 7
additional 220v/20A circuits shall be added along with a new electrical panel will be connected to the existing roof mounted back up generator. In addition, one existing outlet shall be placed on backup power as well as the 2hp

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

 
motor driving the roof mounted exhaust fan. Location of these outlets are as indicated on the accompanying plans. Tenant shall share the cost of maintenance and repairs of the back up generator
with any other tenants who are also connected to it. All electrical power, natural gas and water to the tenant’s premises and equipment will be separately metered and read monthly by the landlord for reimbursement by the tenant. New standby
power outlets will be added as indicated on attached drawing. New normal power outlets will be added as indicated on attached drawing. All electrical circuits will be labeled via labels at the outlet, junction box, safety switch, or other
corresponding electrical equipment and a corresponding label on the electrical panel indicating the appropriate circuit breaker. 
 CO2 Piping: Piping for tenants C02 shall be installed as indicated in the accompanying drawings. These shall consist of 1/2:” copper piping from tenant’s existing “tank farm”, 20 CO2
drops to  1/2” ball valve to  1/4” hose barbs as indicated, 16 brass
 1/2” ball valve shut-offs and 5 above ceiling capped  1/2” copper lines for future use. Gas regulators, if required, shall be provided by the tenant.

 Vacuum lines will be installed as shown on the attached drawing. Vacuum drops will consist
of  1/2” type L copper piping from the house vacuum system to drops as indicated on the attached drawing. Each drop will consist of  1/2” copper pipe to  1/2” ball valve to
 1/4” hose barb. 
 BluebirdBio or their designee will have access to
the space during renovation to inspect the progress and that the work being done conforms to this scope. 
 Fire Protection: Fire protection
will be added as needed and required by Massachusetts Building Code, NFPA and local Fire Code. 
 Work included in this scope will comply with
both the Massachusetts Building Code and NFPA. 
 Laboratory Safety Showers/Eyewash stations will be installed as required per ANSI standards.

 Work will be conducted as indicated by attached drawing keynotes. 
 Scope of Work to include all Keynotes in attached drawings with the exception of MEPs in the Radio Isotope Room. 
 Drawings included in this scope of work are diagrammatic in nature. All pre-existing construction and new construction will be reviewed by the landlord’s architect and engineer to insure indicated
changes are made in accordance with Massachusetts Building Code and the NFPA. 

  

			
	BluebirdBio Final Scope of Work	 	8/13/2012

  
 

 

  
 

 

  
 

 

  
 

 

  
 

 

  
 

 

  
 

 

  
 

 

			
	 BLUEBIRD BIO, INC.

SECOND LEASE EXTENSION
 AND
MODIFICATION AGREEMENT
	  	EXHIBIT B

 See Attached 

 EXHIBIT B—Operating Expenses 2011 
 840 Memorial Drive—Riverside Technology Center 
  

									
	 DESCRIPTION
	  	Total	 	  	PSF	 
	 HEAT
	  	$	36,863	  	  	$	0.28	  
	 BUILDING ELECTRIC
	  	$	152,969	  	  	$	1.18	  
	 WATER & SEWER
	  	$	30,053	  	  	$	0.23	  
	 ELEVATOR MAINTENANCE
	  	$	19,295	  	  	$	0.15	  
	 PARKING/CAFÉ EXPENSE
	  	$	26,525	  	  	$	0.20	  
	 RUBBISH REMOVAL
	  	$	17,104	  	  	$	0.13	  
	 INSURANCE
	  	$	30,234	  	  	$	0.23	  
	 GROUNDS CARE
	  	$	19,459	  	  	$	0.15	  
	 LEGAL/ACCT/ADMIN
	  	$	18,675	  	  	$	0.14	  
	 JANITORIAL SERVICES
	  	$	47,707	  	  	$	0.37	  
	 GENERAL MAINTENANCE
	  	$	63,172	  	  	$	0.49	  
	 HVAC MAINTENANCE
	  	$	47,827	  	  	$	0.37	  
	 LIFE SAFETY SYSTEMS
	  	$	29,593	  	  	$	0.23	  
	 MANAGEMENT*
	  	$	280,302	  	  	$	2.16	  
		  	  
	  
	 	  	  
	  
	 
	 Real Estate Taxes (FY 2011)
	  	$	659,946	  	  	$	5.10	  
		  	  
	  
	 	  	  
	  
	 

  

	*	Based upon 5% of income; but not less than this amount. 

 Tenant’s Applicable Percentage is as follows: 
 As to the Leased Premises: 13.69%. 

Existing Premises: 7.40% 
 Expansion Premises:
6.29%

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