Document:

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                                                                   Exhibit 10.24

                            SECOND AMENDMENT TO LEASE

         (Phase 3 Science Center / Nastech Pharmaceutical Company, Inc.)

         THAT CERTAIN LEASE ("Lease") dated April 23, 2002, by and between PHASE
3 SCIENCE CENTER LLC, a Delaware limited liability company (formerly a
California limited liability company), AHWATUKEE HILLS INVESTORS, LLC, an
Arizona limited liability company, and J. ALEXANDER'S LLC, a Delaware limited
liability company, as tenants in common (collectively, "Landlord"), and NASTECH
PHARMACEUTICAL COMPANY, INC., a Delaware corporation ("Tenant"), for those
certain Premises described in the Lease at 3450 Monte Villa Parkway, Bothell,
Washington, as amended by that certain First Amendment to Lease dated effective
July 1, 2003, is hereby amended by this Second Amendment to Lease (this "Second
Amendment") on or about January 29, 2004, as follows:

         1.       PREMISES.

                  Section 1.1 is amended to add Space A to the Premises
effective January 1, 2005, as shown on the schematic attached hereto as Exhibit
"C", which supercedes and replaces the Exhibit "C" attached to the Lease, so
that the Premises will consist of Spaces A, B, C, D and E as shown on Exhibit
"C", which is the entirety of the Building.

         2.       RENTABLE AREA.

                  Sections 1.1 and 2.1.1 are amended to increase the Rentable
Area of the Premises from 37,014 square feet to 51,000 square feet effective
January 1, 2005, to reflect the addition of 13,986 square feet of Rentable Area
in Space A.

         3.       EXTENSION OF TERM. The term of the Lease shall be extended
three (3) years, and the new Term Expiration Date shall be January 31, 2016.

         4.       BASIC ANNUAL RENT.

                  Sections 2.1.2 and 2.1.3, and any other affected provisions of
the Lease, are amended as follows:

                  Basic Annual Rent otherwise payable under the Lease shall be
increased effective January 1, 2005, by an amount equal to 13,986 square feet
multiplied by the Basic Annual Rent per square foot payable for the balance of
the Premises (Spaces B, C, D and E), such that the Basic Annual Rent per square
foot of the additional space (Space A) shall be the same as the Basic Annual
Rent per square foot of the balance of the space (Spaces B, C, D and E).

                  The Monthly Installments of Basic Annual Rent shall be
one-twelfth (1/12) of the Basic Annual Rent as increased by the preceding
paragraph.

                  The entire Basic Annual Rent as increased effective January 1,
2005, shall be subject to further annual adjustments pursuant to Section 6.1 of
the Lease on each annual
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anniversary of the original Term Commencement Date.

If Tenant desires to lease Space A prior to January 1, 2005, and if Landlord
agrees to lease Space A to Tenant prior to January 1, 2005, Space A shall be
added to the Premises effective the date agreed to by the parties. In such event
Tenant shall pay one-half (1/2) of the Basic Annual Rent otherwise payable for
Space A through December 31, 2004, and 100% of Operating Expenses as set forth
in Paragraph 5 hereof.

         5.       PRO RATA SHARE.

                  Sections 2.1.4 and 7.3(a) are amended to provide that Tenant's
Pro Rata Share is increased to 100% effective January 1, 2005, so that
commencing January 1, 2005 Tenant shall be responsible for the entirety of the
Operating Expenses of the Project.

         6.       SECURITY DEPOSIT.

                  Section 2.1.6(b) and Article 9 are amended to provide that the
Letter of Credit shall be increased from $648,210 to $998,210. Tenant shall
deliver an additional or replacement Letter of Credit to Landlord no later than
February 1, 2005 reflecting the increase, which additional or replacement Letter
of Credit shall continue to be subject to the terms and conditions of Article 9
of the Lease.

         7.       CONSTRUCTION AND POSSESSION.

                  Possession of the additional Premises (Space A) shall be
delivered to Tenant on January 1, 2005. Tenant accepts the additional Premises
in their present, as-is condition. Improvements to the additional Premises, if
any, shall be at the sole cost and expense of Tenant, and shall be governed by
Article 17 (Alterations) of the Lease. Landlord acknowledges that Landlord's
obligation described in Article 14 (Conditions of Premises) of the Lease applies
to the entire Premises.

         8.       COMMON AREAS AND PARKING FACILITIES.

                  The first sentence of Section 15.3 is amended to read as
follows: As an appurtenance to the Premises, Tenant, and its employees and
invitees, shall be entitled to use without charge all of the available parking
spaces located on the Project.

         Terms with an initial capital letter which are not defined in this
Second Amendment shall have the meanings given them in the Lease.

         In all other respects, the Lease as modified by the First Amendment
shall remain in full force and effect.

         IN WITNESS WHEREOF, the parties hereto have executed this Second
Amendment effective the date written above.
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LANDLORD:

Dated: February 17, 2004
       _________________

PHASE 3 SCIENCE CENTER LLC
A Delaware limited liability company

By:  Phase 3 Properties, Inc.
     A California corporation
     Its Manager

     By:  /s/ W. Neil Fox, III
          ______________________________
          W. Neil Fox, III
          Chief Executive Officer

TENANT:

Dated: February 6, 2004
       ________________

NASTECH PHARMACEUTICAL COMPANY, INC.
A Delaware corporation

By:  /s/ Gregory Weaver
     ______________________________
     Name:   Gregory L Weaver
     Title:  Chief Financial Officer<PAGE>
                                                                EXHIBIT 10.11

                                  AMENDMENT TO
                            THE AMENDED AND RESTATED
                      CHANGE IN CONTROL SEVERANCE AGREEMENT

         THIS AMENDMENT TO THE AMENDED AND RESTATED CHANGE IN CONTROL SEVERANCE
AGREEMENT (the "Amendment") is made and entered into as of the 30th day of
September 2003 by and between ALLEGHENY TECHNOLOGIES INCORPORATED, a Delaware
company (the "Company"), and JAMES L. MURDY, and individual (the "Executive").

         WHEREAS, the Company and the executive are parties to an Amended and
Restated Change in Control Severance Agreement as initially effective as of
February 10, 2000 and as most recently amended as of March 12, 2003 (as amended
and in effect, the "Agreement");

         WHEREAS, the Agreement provides the Executive with a number of rights
and potential payments in the event of a Change in Control of the Company (as
defined in the Agreement);

         WHEREAS, absent this Amendment, the Agreement would expire on October
1, 2003, the first day of the Executive's scheduled retirement;

         WHEREAS, the Company and the Executive intend to continue into his
retirement the protection provided under the Agreement for the Executive with
respect to any accrued but then unpaid installment under the Company's
Supplemental Retirement Plan (the "SRP") in the event of a Change in Control,
namely, that any accrued but then unpaid amount under the SRP would be paid in a
single lump sum cash payment; and

         WHEREAS, the parties intend to evidence that intention by entering into
this Amendment.

         NOW, THEREFORE, intending to be legally bound and in consideration of
the mutual promises hereinafter made, the parties agree as follows:

         1. Defined Terms. The initially capitalized terms set forth in the
Agreement are incorporated into this Amendment as if set forth at length and
shall have the meanings in this Amendment ascribed to them in the Agreement.

         2. Term of the Amendment. This Amendment shall be and remain in effect
until each and all installments under the SRP are paid to the Executive or his
beneficiary either in accordance with the terms of the SRP or as provided in
Section 3 of the this Amendment. Without limiting the generality of the
foregoing, this Amendment is intended to remain in force and effect after the
retirement of the Executive and remain in force indefinitely until all SRP
payments have been made in full.

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         3. Payment of SRP Amounts. Upon the occurrence of a Change in Control,
the Company shall pay to the Executive in a single, lump sum cash payment within
three (3) business days following occurrence of the Change in Control an amount
determined by adding together the face amount of all accrued but then unpaid
installments due the Executive (and/or his beneficiary if the Executive has died
between his retirement date and the date of the Change in Control) under the
SRP. The payment of such amount shall not be conditioned upon any event other
than a Change in Control and no demand on behalf of the Executive need be made
to make such payment due and payable.

         4. Effect on Agreement. Except as modified in this Amendment, the
Agreement shall remain in effect and shall be enforceable in accordance with its
terms. Without limiting the generality of the foregoing, it is understood by the
parties that the Executive shall not and cannot become entitled to a Severance
Benefit following a Change in Control that occurs after his retirement.

IN WITNESS WHEREOF, the parties have executed this Amendment as of the date
first above written.

                                         ALLEGHENY TECHNOLOGIES
                                         INCORPORATED

                                         /s/ Jon D. Walton
                                         --------------------------------
                                         Senior Vice President, Chief
                                         Legal and Administrative Officer

                                         JAMES L. MURDY

                                         /s/ James L. Murdy
                                         -------------------------------

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