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Exhibit 10.42    
    

 
 

SEPRACOR INC.    
    
    Form of Incentive Stock Option Agreement
  Granted Under 2000 Stock Incentive Plan    
    

1.    Grant of Option. 

        This
agreement evidences the grant by Sepracor Inc., a Delaware corporation (the "Company"), on the Grant Date indicated on the preceding Certificate of Stock Option Grant (the
"Certificate") to an employee of the Company (the "Participant"), of an option to purchase, in whole or in part, on the terms provided herein and in the Company's 2000 Stock Incentive Plan (the
"Plan"), the number o shares (the "Shares") of common stock, $.10 par value per share, of the Company ("Common Stock"), indicated on the certificate at the price per Share indicated on the
Certificate. Unless earlier terminated, this option shall expire on the Grant Expiration Date indicated on the Certificate (the "Grant Expiration Date"). 

        It
is intended that the option evidenced by this agreement shall be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and any
regulations promulgated thereunder (the "Code"). Except as otherwise indicated by the context, the term "Participant", as used in this option, shall be deemed to include any person who acquires the
right to exercise this option validly under its terms. 

2.    Vesting Schedule. 

        This
option will become exercisable ("vest") pursuant to the Vesting Schedule indicated on the Certificate ("Vesting Schedule"). 

        The
right of exercise shall be cumulative so that to the extent the option is not exercised in any period to the maximum extent permissible it shall continue to be exercisable, in whole
or in part, with respect to all shares for which it is vested until the earlier of the Grant Expiration Date or the termination of this option under Section 3 hereof or the Plan. 

3.    Exercise of Option. 

        (a)    Form of Exercise.    Each election to exercise this option shall be in writing, signed by the Participant, and
received by the Company at its principal office, accompanied by this agreement, and payment in full in the manner provided in the Plan. The Participant may purchase less than the number of shares
covered hereby, provided that no partial exercise of this option may be for any fractional share. 

        (b)    Continuous Relationship with the Company Required.    Except as otherwise provided in this Section 3,
this option may not be exercised unless the Participant, at the time he or she exercises this option, is, and has been at all times since the Grant Date, an employee or officer of, or consultant or
advisor to, the Company or any parent or subsidiary of the Company as defined in Section 424(e) or (f) of the Code (an "Eligible Participant"). 

        (c)    Termination of Relationship with the Company.    If the Participant ceases to be an Eligible Participant for
any reason, then, except as provided in paragraphs (d) and (e) below, the right to exercise this option shall terminate three months after such cessation (but in no event after the Grant
Expiration Date), provided that this option shall be exercisable only to the extent that the Participant was entitled to exercise this option on the
date of such cessation. Notwithstanding the foregoing, if the Participant, prior to the Grant Expiration Date, violates the non-competition or confidentiality provisions of any employment
contract, confidentiality and nondisclosure agreement or other agreement between the Participant and the Company, the right to exercise this option shall terminate immediately upon written notice to
the Participant from the Company describing such violation. 

 

        (d)    Exercise Period Upon Death or Disability.    If the Participant dies or becomes disabled (within the meaning of
Section 22(e)(3) of the Code) prior to the Grant Expiration Date while he or she is an Eligible Participant and the Company has not terminated such relationship for "cause" as specified in
paragraph (e) below, this option shall be exercisable, within the period of one year following the date of death or disability of the Participant, by the Participant (or in the case of death by
an authorized transferee), provided that this option shall be exercisable only to the extent that this option was exercisable by the Participant on the
date of his or her death or disability, and further provided that this option shall not be exercisable after the Grant Expiration Date. 

        (e)    Discharge for Cause.    If the Participant, prior to the Grant Expiration Date, is discharged by the Company
for "cause" (as defined below), the right to exercise this option shall terminate immediately upon the effective date of such discharge. "Cause" shall mean willful misconduct by the Participant or
willful failure by the Participant to perform his or her responsibilities to the Company (including, without limitation, breach by the Participant of any provision of any employment, consulting,
advisory, nondisclosure, non-competition or other similar agreement between the Participant and the Company), as determined by the Company, which determination shall be conclusive. The
Participant shall be considered to have been discharged for "Cause" if the Company determines, within 30 days after the Participant's resignation, that discharge for cause was warranted. 

4.    Withholding. 

        No
Shares will be issued pursuant to the exercise of this option unless and until the Participant pays to the Company, or makes provision satisfactory to the Company for payment of, any
federal, state or local withholding taxes required by law to be withheld in respect of this option. 

5.    Nontransferability of Option. 

        This
option may not be sold, assigned, transferred, pledged or otherwise encumbered by the Participant, either voluntarily or by operation of law, except by will or the laws of descent
and distribution, and, during the lifetime of the Participant, this option shall be exercisable only by the Participant. 

6.    Disqualifying Disposition. 

        If
the Participant disposes of Shares acquired upon exercise of this option within two years from the Grant Date or one year after such Shares were acquired pursuant to exercise of this
option, the Participant shall notify the Company in writing of such disposition. 

7.    Provisions of the Plan. 

        This
option is subject to the provisions of the Plan, a copy of which is furnished to the Participant with this option. 

2

 

IN
WITNESS WHEREOF, the Company has caused this option to be executed under its corporate seal by its duly authorized officer. This option shall take effect as a sealed instrument. 

	 	 	SEPRACOR INC.
	

 	
 	

By:	

PARTICIPANT'S ACCEPTANCE 

        The
Participant hereby accepts the foregoing option and agrees to the terms and conditions thereof. The Participant hereby acknowledges receipt of a copy of the Company's 2000 Stock
Incentive Plan. 

3

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Exhibit 10.42

SEPRACOR INC. Form of Incentive Stock Option Agreement Granted Under 2000 Stock Incentive PlanQuickLinks
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Exhibit 10.43    
    

 
 

SEPRACOR INC.    
    
    Form of Nonstatutory Stock Option Agreement
  Granted Under 2000 Stock Incentive Plan    
    

1.    Grant of Option. 

        This
agreement evidences the grant by Sepracor Inc., a Delaware corporation (the "Company"), on the Grant Date indicated on the preceding Certificate of Stock Option Grant (the
"Certificate") to an employee, consultant, or director of the Company (the "Participant"), of an option to purchase, in whole or in part, on the terms provided herein and in the Company's 2000 Stock
Incentive Plan (the "Plan"), the number of shares (the "Shares") of common stock, $.10 par value per share, of the Company ("Common Stock"),indicated on the certificate at the price per Share
indicated on the Certificate. Unless earlier terminated, this option shall expire on the Grant Expiration Date indicated on the Certificate ("Grant Expiration Date"). 

        It
is intended that the option evidenced by this agreement shall not be an incentive stock option as defined in Section 422 of the Internal Revenue Code of 1986, as amended, and
any regulations promulgated thereunder (the "Code"). Except as otherwise indicated by the context, the term "Participant", as used in this option, shall be deemed to include any person who acquires
the right to exercise this option validly under its terms. 

2.    Vesting Schedule. 

        This
option will become exercisable ("vest") pursuant to the Vesting Schedule indicated on the Certificate ("Vesting Schedule"). 

        The
right of exercise shall be cumulative so that to the extent the option is not exercised in any period to the maximum extent permissible it shall continue to be exercisable, in whole
or in part, with respect to all shares for which it is vested until the earlier of the Grant Expiration Date or the termination of this option under Section 3 hereof or the Plan. 

3.    Exercise of Option. 

        (a)    Form of Exercise.    Each election to exercise this option shall be in writing, signed by the Participant, and
received by the Company at its principal office, accompanied by this agreement, and payment in full in the manner provided in the Plan. The Participant may purchase less than the number of shares
covered hereby, provided that no partial exercise of this option may be for any fractional share. 

        (b)    Continuous Relationship with the Company Required.    Except as otherwise provided in this Section 3,
this option may not be exercised unless the Participant, at the time he or she exercises this option, is, and has been at all times since the Grant Date, an [employee or officer
of], or consultant or advisor to, the Company or any parent or subsidiary of the Company as defined in Section 424(e) or (f) of the Code (an "Eligible Participant"). 

        (c)    Termination of Relationship with the Company.    If the Participant ceases to be an Eligible Participant for
any reason, then, except as provided in paragraphs (d) and (e) below, the right to exercise this option shall terminate three months after such cessation (but in no event after the Grant
Expiration Date), provided that this option shall be exercisable only to the extent that the Participant was entitled to exercise this option on the
date of such cessation. Notwithstanding the foregoing, if the Participant, prior to the Grant Expiration Date, violates the non-competition or confidentiality provisions of any employment
contract, confidentiality and nondisclosure agreement or other agreement between the Participant and the Company, the right to exercise this option shall terminate immediately upon written notice to
the Participant from the Company describing such violation. 

 

        (d)    Exercise Period Upon Death or Disability.    If the Participant dies or becomes disabled (within the meaning of
Section 22(e)(3) of the Code) prior to the Grant Expiration Date while he or she is an Eligible Participant and the Company has not terminated such relationship for "cause" as specified in
paragraph (e) below, this option shall be exercisable, within the period of one year following the date of death or disability of the Participant, by the Participant (or in the case of death by
an authorized transferee), provided that this option shall be exercisable only to the extent that this option was exercisable by the Participant on the
date of his or her death or disability, and further provided that this option shall not be exercisable after the Grant Expiration Date. 

        (e)    Discharge for Cause.    If the Participant, prior to the Grant Expiration Date, is discharged by the Company
for "cause" (as defined below), the right to exercise this option shall terminate immediately upon the effective date of such discharge. "Cause" shall mean willful misconduct by the Participant or
willful failure by the Participant to perform his or her responsibilities to the Company (including, without limitation, breach by the Participant of any provision of any employment, consulting,
advisory, nondisclosure, non-competition or other similar agreement between the Participant and the Company), as determined by the Company, which determination shall be conclusive. The
Participant shall be considered to have been discharged for "Cause" if the Company determines, within 30 days after the Participant's resignation, that discharge for cause was warranted. 

4.    Withholding. 

        No
Shares will be issued pursuant to the exercise of this option unless and until the Participant pays to the Company, or makes provision satisfactory to the Company for payment of, any
federal, state or local withholding taxes required by law to be withheld in respect of this option. 

5.    Nontransferability of Option. 

        This
option may not be sold, assigned, transferred, pledged or otherwise encumbered by the Participant, either voluntarily or by operation of law, except by will or the laws of descent
and distribution, and, during the lifetime of the Participant, this option shall be exercisable only by the Participant. 

6.    Provisions of the Plan. 

        This
option is subject to the provisions of the Plan, a copy of which is furnished to the Participant with this option. 

2

 

IN
WITNESS WHEREOF, the Company has caused this option to be executed under its corporate seal by its duly authorized officer. This option shall take effect as a sealed instrument. 

SEPRACOR INC. 

PARTICIPANT'S ACCEPTANCE 

        The
Participant hereby accepts the foregoing option and agrees to the terms and conditions thereof. The Participant hereby acknowledges receipt of a copy of the Company's 2000 Stock
Incentive Plan. 

3

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Exhibit 10.43

SEPRACOR INC. Form of Nonstatutory Stock Option Agreement Granted Under 2000 Stock Incentive Plan

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