Document:

Lease Agreement dated July 12,2004

 Exhibit 10.6 
 LEASE 
  

			
	Landlord:	  	Hayward Point Eden I Limited Partnership
		
	Tenant:	  	Acologix, Inc.
		
	Date:	  	July 12, 2004

 LEASE 
 THIS LEASE is made and entered into as of the 12th day of July, 2004, by and between Hayward Point Eden I Limited Partnership, a Delaware
limited partnership (“Landlord”) and Acologix, Inc., a Delaware corporation (“Tenant”). 
 THE PARTIES AGREE
AS FOLLOWS: 
  

	1.	PREMISES 

 1.1 Premises. 
 Landlord leases to Tenant and Tenant hires and leases from Landlord, on the terms, covenants and conditions hereinafter set forth, the
premises (the “Premises”) designated in Exhibit A attached hereto and incorporated herein by this reference, consisting of approximately 17,132 square feet of space located within Building D (the “Building”)
in the Britannia Point Eden Business Park (the “Center”) in the City of Hayward, County of Alameda, State of California, commonly known as 3960 Point Eden Way, and located on the real property (the “Property”)
described in Exhibit B attached hereto and incorporated herein by this reference, together with the nonexclusive right to use any common areas designated from time to time in any Declaration of Covenants, Conditions and Restrictions or
similar document affecting the Center. The Premises are divided into two areas, the Phase I Premises and the Phase II Premises. The Phase I Premises consist of approximately 14,144 square feet of space, and are designated in Exhibit A. The
Phase II Premises consist of approximately 2,988 square feet of space, and are designated in Exhibit A. 
 1.2 Landlord’s
Reserved Rights. Landlord reserves the right from time to time to (i) install, use, maintain, repair and replace pipes, ducts, conduits, wires and appurtenant meters and equipment for service to other parts of the Building above the ceiling
surfaces, below the floor surfaces, within the walls or leading through the Premises in locations which will not materially interfere with Tenant’s use thereof, (ii) relocate any pipes, ducts, conduits, wires and appurtenant meters and
equipment included in the Premises which are so located or located elsewhere outside the Premises, (iii) make alterations or additions to the Building, (iv) construct, alter or add to other buildings or improvements on the Property,
(v) build adjoining to the Property, and (vi) lease any part of the Property for the construction of improvements or buildings. Landlord may modify or enlarge the common area, alter or relocate accesses to the Premises, or alter or
relocate any common facility. Landlord shall not exercise rights reserved to it pursuant to this Section 1.2 in such a manner as to materially impair Tenant’s ability to conduct its activities in the normal manner or materially increase
the obligations or materially decrease rights of Tenant under this Lease; provided, however, that the foregoing shall not limit or restrict Landlord’s right to undertake reasonable construction activity and Tenant’s use of the
Premises shall be subject to reasonable temporary disruption incidental to such activity diligently prosecuted. 
  

	2.	TERM 

 2.1 Term. The term of this Lease with
respect to the Phase I Premises shall commence on the later to occur of (a) the date which is five (5) days after the date Landlord notifies Tenant that Landlord’s work in the Phase I Premises pursuant to Section 2.4 and 

 
Exhibit C is substantially complete and Landlord has delivered possession of the Phase I Premises to Tenant with such Landlord’s work completed
or (b) November 1, 2004 (the “Commencement Date,”) and shall end on the day immediately preceding the date seven (7) years thereafter, unless sooner terminated as hereinafter provided. The term of this Lease with
respect to the Phase II Premises shall commence on the later to occur of (a) the date which is five (5) days after the date Landlord notifies Tenant that Landlord’s work in the Phase II Premises pursuant to Section 2.4 and
Exhibit C is substantially complete and Landlord has delivered possession of the Phase II Premises to Tenant with such Landlord’s work completed or (b) the date that falls twelve months after the Commencement Date (the
“Phase II Premises Commencement Date”) and shall end on the day immediately preceding the date seven (7) years after the Commencement Date, unless sooner terminated as hereinafter provided. The Commencement Date is expected to
occur on or about December 1, 2004. The Phase II Commencement Date is expected to occur on or about December 1, 2005. Notwithstanding anything to the contrary in this Section 2.1, if the Commencement Date has not occurred by
April 1, 2005, then Tenant may terminate this Lease by written notice to Landlord, provided, however, that if the Commencement Date has been delayed for force majeure events such as fires, acts of war, earthquakes, labor unrest (a “force
majeure delay”), then the April 1, 2005 date described in this sentence shall be extended by the time period or periods of the force majeure delay, which may not exceed 120 days; in addition, the April 1, 2005 date shall be extended
for all delays caused by Tenant. 
 2.2 Early Possession. If Landlord permits Tenant to occupy, use or take possession of the Phase I
Premises prior to the Commencement Date or the Phase II Premises prior to the Phase II Premises Commencement Date, both determined under Section 2.1, such occupancy, use or possession shall be subject to and upon all of the terms and conditions
of this Lease, including the obligation to pay rent and other charges, unless Landlord and Tenant agree otherwise; provided, however, that such early possession shall not advance or otherwise affect the Commencement Date or termination date
determined under Section 2.1. Landlord shall permit Tenant to take early possession solely for the purpose of installing fixtures and equipment and other similar work preparatory to the commencement of business in the Premises, and Tenant shall
not be required to pay rent or Operating Expenses by reason of such possession until the Commencement Date otherwise occurs, provided that Tenant shall not interfere with or delay Landlord’s contractors by such early possession and shall
indemnify, defend and hold harmless Landlord and its agents and employees from and against any and all claims, demands, liabilities, actions, losses, costs and expenses, including (but not limited to) reasonable attorneys’ fees, arising out of
or in connection with Tenant’s early entry upon the Premises hereunder. 
 2.3 Delay In Possession. Landlord agrees to use its
best reasonable efforts to complete promptly the work described in Section 2.4 and Exhibit C; provided, however, Landlord shall not be liable for any damages caused by any delay in the completion of such work, nor shall any such
delay affect the validity of this Lease or the obligations of Tenant hereunder. 
 2.4 Construction. The obligation of Landlord to
perform work to improve the Premises for occupancy is set forth in Exhibit C attached hereto and incorporated herein by this reference (the “Tenant Improvements”). Except as set forth in Exhibit C and this
Section 2.4, Landlord shall have no responsibilities or obligations with respect to preparation of the Premises for Tenant’s occupancy. Except as set forth in this Section 2.4, acceptance by Tenant of possession of the Premises after
performance of such work, if any, by Landlord shall constitute acceptance by Tenant of such work in its then completed condition and Landlord shall have no further responsibility of any kind or character for improvement of the Premises or in
connection with such work; provided, however, that (a) within thirty (30) days after the Commencement Date, Tenant may furnish to Landlord a “punch list” identifying any items or matters in the Phase I Premises, which are
not constructed in accordance with this Lease and the plans and specifications approved under Exhibit C hereto and Landlord shall promptly and diligently correct all such matters at its sole cost and expense and (b) within thirty
(30) days after the Phase II Premises Commencement Date, Tenant may furnish to Landlord a “punch list” identifying any items or matters in the Phase II Premises, which are not constructed in accordance with this Lease and the plans
and specifications approved under Exhibit C hereto and Landlord shall promptly and diligently correct all such matters at its sole cost and expense. 
  

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 Effective upon delivery of the Phase I Premises and the Phase II Premises, respectively, to Tenant,
Landlord warrants that (a) the construction of the Tenant Improvements in such area of the Premises was performed in accordance with all applicable governmental codes, laws and regulations in force at the time such work was completed, in
accordance with the final plans and specifications developed in accordance with Exhibit C, and in a good and workman-like manner, (b) all material and equipment installed therein conformed to the final plans and specifications and was new and
otherwise of good quality, (c) the electrical, plumbing, HVAC, mechanical and other systems servicing such area of the Premises are in working order and in good condition, and (d) the roof is in good condition and water tight.
Notwithstanding anything to the contrary herein, (i) Tenant’s acceptance of the applicable Premises shall not be deemed a waiver of Tenant’s right to have latent defects in the applicable Premises repaired at no cost to Tenant and
(ii) Tenant shall give written notice to Landlord whenever any latent defect that Landlord is obligated to repair becomes reasonably apparent, and Landlord shall repair such defect as soon as practicable. 
 2.5 Acknowledgement Of Lease Commencement. Upon commencement of the term of this Lease, Landlord and Tenant shall execute a written
acknowledgement of the Commencement Date, date of termination, square footage of the applicable portion of the Premises and related matters, substantially in the form attached hereto as Exhibit D (with appropriate insertions), which
acknowledgement shall be deemed to be incorporated herein by this reference. Notwithstanding the foregoing requirement, the failure of one or both parties to execute such a written acknowledgement shall not affect the determination of the
Commencement Date, date of termination, square footage of the Premises and related matters in accordance with the provisions of this Lease. 
 2.6 Holding Over. If Tenant holds possession of the Premises after the term of this Lease with Landlord’s written consent, then except as otherwise specified in such consent, Tenant shall become a tenant from month to month at
one hundred twenty-five percent (125%) of the rental and otherwise upon the terms herein specified for the period immediately prior to such holding over and shall continue in such status until the tenancy is terminated by either party upon not
less than thirty (30) days prior written notice. If Tenant holds possession of the Premises after the term of this Lease without Landlord’s written consent, then Landlord in its sole discretion may elect (by written notice to Tenant) to
have Tenant become a tenant either from month to month or at will, at one hundred fifty percent (150%) of the rental (prorated on a daily basis for an at-will tenancy, if applicable) and otherwise upon the terms herein specified for the period
immediately prior to such holding over, or may elect to pursue any and all legal remedies available to Landlord under applicable law with respect to such unconsented holding over by Tenant. Tenant shall indemnify and hold Landlord harmless from any
loss, damage, claim, liability, cost or expense (including reasonable attorneys’ fees) resulting from any delay by Tenant in surrendering the Premises (except with Landlord’s prior written consent), including but not limited to any claims
made by a succeeding tenant by reason of such delay. Acceptance of rent by Landlord following expiration or termination of this Lease shall not constitute a renewal of this Lease. 
 2.7 Option To Extend Term. Tenant shall have the option to extend the term of this Lease, at the minimum rental set forth in
Section 3.1(d) and otherwise upon all the terms and provisions set forth herein with respect to the initial term of this Lease, for up to one additional period of three (3) years, commencing upon expiration of the initial term hereof.
Exercise of such option shall be by written notice to Landlord at least six (6) months and not more than twelve (12) months prior to the expiration of the initial term hereof. If on the date of such notice or on the date any extended term
is to commence, Tenant is either (a) in default of a payment obligation (a “payment default”) or (b) in default of any other obligation and the cure period for such nonpayment default has lapsed then the option shall be of no
force or effect, the extended term shall not commence and this Lease shall expire at the end of the then current term hereof (or at such earlier time as Landlord may elect pursuant to the default provisions of this Lease). If Tenant properly
exercises the extension option under this Section, then all references in this Lease (other than in this Section 2.7) to the “term” of this Lease shall be construed to include the extension term thus elected by Tenant. Except
as expressly set forth in this Section 2.7, Tenant shall have no right to extend the term of this Lease beyond its prescribed term. 
  

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	3.	RENTAL 

 3.1 Minimum Rental. 
 (a) Tenant shall pay to Landlord as minimum rental for the Premises, in advance, without deduction, offset, notice or demand, on or before
the Commencement Date and on or before the first day of each subsequent calendar month of the term of this Lease, the following amounts per month: 
  

				
	 Months
	  	Minimum Rental
	 1-12
	  	$	30,395.46
	 13-24
	  	$	37,921.17
	 25-36
	  	$	39,058.81
	 37-48
	  	$	40,230.57
	 49-60
	  	$	41,437.49
	 61-72
	  	$	42,680.61
	 73-84
	  	$	43,961.03

 Notwithstanding the foregoing minimum rental schedule, if the Phase II Commencement Date occurs after the twelve
month anniversary of the Commencement Date, then the minimum rental shall be reduced for the period from the twelve month anniversary of the Commencement Date through the Phase II Commencement Date by $6,613.85; that reduction will be increased by
3% every twelve months until the Phase II Premises Commencement Date occurs. 
 If the obligation to pay minimum rental hereunder commences on other than the
first day of a calendar month or if the term of this Lease terminates on other than the last day of a calendar month, the minimum rental for such first or last month of the term of this Lease, as the case may be, shall be prorated based on the
number of days the term of this Lease is in effect during such month. If an increase in minimum rental becomes effective on a day other than the first day of a calendar month, the minimum rental for that month shall be the sum of the two applicable
rates, each prorated for the portion of the month during which such rate is in effect. 
 (b) The minimum rental amounts
specified in this Section 3.1 are agreed on amounts and are not subject to adjustment if the actual area of the Premises, when completed, is greater or less than the estimated area of the Premises. 
 (c) If Tenant properly exercises its right to extend the term of this Lease pursuant to Section 2.7 hereof, the minimum rental during
the extended term shall be equal to ninety-five percent (95%) of the fair market rental value of the Premises (as theretofore improved under Section 2.4 and Exhibit C and taking into consideration that there will be no free rent,
tenant improvement allowances or other similar concessions), including any cost-of-living adjustments or other rental increase provisions then customary in the relevant market for comparable commercial leases, determined as of the commencement of
such extended term in accordance with this paragraph. Upon Landlord’s receipt of a proper notice of Tenant’s exercise of its option to extend the term of this Lease, or, if Tenant notifies Landlord of Tenant’s exercise of the option
more than 240 days before the expiration of the initial term, beginning on the date which is 240 days before the expiration of the initial term, the parties shall have sixty (60) days in which to agree on the Fair Market Rental (including any
applicable rental increase provisions) for the Premises (as theretofore improved under Section 2.4 and Exhibit C) at the commencement of the extended term for the uses permitted hereunder. If the parties agree on such Fair Market Rental
and rental increase provisions (if any), they shall execute an amendment to this Lease stating the amount of the applicable minimum monthly rental and any applicable rental increase provisions. If the parties are unable to agree on the Fair Market
Rental (including any applicable rental increase provisions) within such sixty (60) day period, then within fifteen (15) days after the expiration of such period each party, at its cost and by giving notice to the other party, shall
appoint a real estate appraiser with at least five (5) years experience appraising similar commercial properties in the city or county in which the Property is located or neighboring areas, to appraise and set the Fair Market Rental and any
applicable rental increase provisions for the Premises at the commencement of the extended term. If either party fails to appoint an appraiser within the allotted time, the single appraiser appointed by the other party shall be the sole appraiser.
If an appraiser is appointed by each party and the two appraisers so appointed are unable to agree upon a Fair Market Rental (and any appropriate rental increase provisions) within thirty (30) days after the appointment of the second, they
shall appoint a third 

  

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qualified appraiser within ten (10) days after expiration of such 30-day period; if they are unable to agree upon a third appraiser, either party may,
upon not less than five (5) days notice to the other party, apply to the Presiding Judge of the Superior Court for the county in which the Property is located for the appointment of a third qualified appraiser. Each party shall bear its own
legal fees in connection with appointment of the third appraiser and shall bear one-half of any other costs of appointment of the third appraiser and of such third appraiser’s fee. The third appraiser, however selected, shall be a person who
has not previously acted for either party in any capacity. Within thirty (30) days after the appointment of the third appraiser, a majority of the three appraisers shall set the fair market rental and any applicable rental increase provisions
for the extended term and shall so notify the parties. If a majority are unable to agree within the allotted time, (i) the three appraised fair market rentals shall be added together and divided by three and the resulting quotient shall be the
Fair Market Rental for the extended term, and (ii) the applicable rental increase provision shall be equal to the mathematical average (or the nearest reasonable approximation thereto) of the two rental increase provisions that are most closely
comparable, which determinations shall be binding on the parties and shall be enforceable in any further proceedings relating to this Lease. 
 3.2 Late Charge. If Tenant fails to pay when due rental or other amounts due Landlord hereunder, such unpaid amounts shall bear interest for the benefit of Landlord at a rate equal to the lesser of fifteen percent (15%) per
annum or the maximum rate permitted by law, from the date due to the date of payment. In addition to such interest, Tenant shall pay to Landlord a late charge in an amount equal to ten percent (10%) of any installment of minimum rental and any
other amounts due Landlord if not paid in full on or before the fifth (5th) day after such rental or other amount is due. Tenant acknowledges that late payment by Tenant to Landlord of rental or other amounts due hereunder will cause Landlord
to incur costs not contemplated by this Lease, including, without limitation, processing and accounting charges and late charges which may be imposed on Landlord by the terms of any loan relating to the Property. Tenant further acknowledges that it
is extremely difficult and impractical to fix the exact amount of such costs and that the late charge set forth in this Section 3.2 represents a fair and reasonable estimate thereof. Acceptance of any late charge by Landlord shall not
constitute a waiver of Tenant’s default with respect to overdue rental or other amounts, nor shall such acceptance prevent Landlord from exercising any other rights and remedies available to it. Acceptance of rent or other payments by Landlord
shall not constitute a waiver of late charges or interest accrued with respect to such rent or other payments or any prior installments thereof, nor of any other defaults by Tenant, whether monetary or non-monetary in nature, remaining uncured at
the time of such acceptance of rent or other payments. 
  

	4.	TAXES 

 4.1 Personal Property. Tenant shall
be responsible for and shall pay prior to delinquency all taxes and assessments levied against or by reason of all alterations and additions and all other items installed or paid for by Tenant under this Lease, and the personal property, trade
fixtures and other property placed by Tenant in or about the Premises. Upon request by Landlord, Tenant shall furnish Landlord with satisfactory evidence of payment thereof. If at any time during the term of this Lease any of said alterations,
additions or personal property, whether or not belonging to Tenant, shall be taxed or assessed as part of the Property, then such tax or assessment shall be paid by Tenant to Landlord immediately upon presentation by Landlord of copies of the tax
bills in which such taxes and assessments are included and shall, for the purposes of this Lease, be deemed to be personal property taxes or assessments under this Section 4.1. 
 4.2 Real Property. To the extent the real property taxes and assessments on the Premises are assessed separately from the remainder of the
Property, Tenant shall be responsible for and shall pay prior to delinquency all such taxes and assessments levied against the Premises. Upon request by Landlord, Tenant shall furnish Landlord with satisfactory evidence of payment thereof. To the
extent the Premises are taxed or assessed as part of the Property, such real property taxes and assessments shall constitute Operating Expenses (as that term is defined in Section 5.2 of this Lease) and shall be paid in accordance with the
provisions of Article 5 of this Lease. 
  

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	5.	OPERATING EXPENSES 

 5.1 Payment Of Operating
Expenses, 
 (a) Tenant shall pay to Landlord, at the time and in the manner hereinafter set forth, as additional rental,
an amount equal to five and eighty-three hundredths percent (5.83%) (“Tenant’s Operating Cost Share”‘) of the Operating Expenses defined in Section 5.2, provided, however, that from the Commencement Date through
the Phase II Premises Commencement Date, Tenant’s Operating Cost Share shall be four and eighty-two hundredths percent (4.82%) of the Operating Expenses. 
 (b) Tenant’s Operating Cost Share as specified in paragraph (a) of this Section is based upon an estimated area of 14,144 square
feet for the Phase I Premises 2,988 square feet for the Phase II Premises, for a total area of 17,132 square feet for the Premises and upon an aggregate area of 293,722 square feet for the buildings owned by Landlord on the Property. If the actual
area of the Premises (when completed) or of the buildings owned by Landlord on the Property, as determined in good faith by Landlord’s architect on a basis consistent with that used in measuring other leased premises within the Center, differs
from the assumed numbers set forth above, then Tenant’s Operating Cost Share shall be adjusted to reflect the actual areas so determined. 
 (c) If Landlord constructs additional buildings on the Property (or on any adjacent property owned by Landlord and operated, for common area purposes, on an integrated basis with the Property) from time to time,
Tenant’s Operating Cost Share shall be adjusted to be equal to the percentage determined by dividing the gross square footage of the Premises as they then exist by the gross square footage of all buildings located on portions of the Property
owned by Landlord (or on any applicable adjacent property owned by Landlord as described above), all measured on a consistent basis. In determining said percentage, a building shall be taken into account (and expenses with respect to such building)
from and after the date on which a tenant first enters into possession of the building or a portion thereof, and the good faith determination of the gross square footage of any such building by Landlord’s architects shall be final and binding
upon the parties. 
 5.2 Definition Of Operating Expenses. Subject to the exclusions and provisions hereinafter contained, the term
“Operating Expenses” shall mean the total costs and expenses incurred by or allocable to Landlord for management, operation and maintenance of the Building and the Property (or on any applicable adjacent property owned by Landlord
as described above), including, without limitation, costs and expenses of (i) insurance, property management, landscaping and operations, repairs and maintenance of buildings and common areas; (ii) all utilities and services;
(iii) real and personal property taxes and assessments or substitutes therefor, including (but not limited to) any possessory interest, use, business, license or other taxes or fees, any taxes imposed directly on rents or services, any
assessments or charges for police or fire protection, housing, transit, open space, street or sidewalk construction or maintenance or other similar services from time to time by any governmental or quasi-governmental entity, and any other new taxes
on landlords in addition to taxes now in effect; (iv) supplies, equipment, utilities and tools used in management, operation and maintenance of the Property; (v) capital improvements to the Property or the Building, amortized over a
reasonable period determined in accordance with generally accepted accounting principles, (aa) which reduce or will cause future reduction of other items of Operating Expenses for which Tenant is otherwise required to contribute or (bb) which are
required by law, ordinance, regulation or order of any governmental authority either not in effect or not applicable to the Premises as of the Commencement Date or (cc) of which Tenant has use or which benefit Tenant; and (vi) any other costs
(including, but not limited to, any parking or utilities fees or surcharges) allocable to or paid by Landlord, as owner of the Property or Building, pursuant to any applicable laws, ordinances, regulations or orders of any governmental or
quasi-governmental authority or pursuant to the terms of any declarations of covenants, conditions and restrictions now or hereafter affecting the Property (or any applicable adjacent property owned by Landlord as described above). Operating
Expenses shall not include any costs attributable to increasing the size of or otherwise expanding the Building or the cost of the work for which Landlord is required to pay under Section 2.4 or Exhibit C. The distinction between items
of ordinary operating maintenance and repair and items of a capital nature shall be made in accordance with generally accepted accounting principles applied on a consistent basis. Notwithstanding anything to the contrary contained in this
Section 5.2, Operating Expenses shall not include costs or expenses incurred by or allocable to Landlord in connection with any of the following: (A) 

  

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repairs, improvements or replacements occasioned by fire or other casualty (including deductibles under earthquake or other property insurance) or by the
exercise of the power of eminent domain (all of which repairs, improvements or replacements, if any, shall be governed by the provisions of Article 13 hereof); (B) correction of any construction defect in the Premises, the Building or the
Center; (C) the removal or remediation of any Hazardous Material (as defined in Section 9.6(a) hereof) present on the Property or in the Center as of the Commencement Date or released on the Property or in the Center after the Commencement
Date through the act or omission of Landlord or its employees or agents or any other third party, except to the extent the release of such Hazardous Material on the Property or in the Center is attributable to any act or omission of Tenant or its
agents, employees, suppliers or licensees; (D) expense reserves; (E) repairs, replacements or improvements which are required to be capitalized under generally accepted accounting principles, except for amounts arising from the annual
amortization of the cost of such repairs, replacements or improvements over the reasonable useful life thereof; (F) assessments in excess of the amount which would be allocable to any specified period if such assessments were paid in
installments over the period over which such assessments are customarily paid by prudent commercial property owners and managers; (G) the negotiation, breach or alleged breach of any other leases affecting the Center or any portion thereof;
(H) the construction of tenant improvements for any other tenants of the Building or the Center; (I) interest, charges and fees incurred or debt, except debt incurred with respect to capital improvements described in clause (v) above;
(J) any tax or assessment attributable to Landlord’s income (other than gross receipts or payroll taxes) inheritance, gift, transfer or estate taxes; (K) costs to comply with any covenant, condition, underwriter’s requirement or
law applicable to the Premises or the Center on the Commencement Date with which Landlord is not complying on the Commencement Date; and (L) property management fees to the extent such fees exceed four percent of the base rent hereunder plus
Operating Expenses for the Property. 
 5.3 Determination Of Operating Expenses. On or before the Commencement Date and during the
last month of each calendar year of the term of this Lease (“Lease Year”), or as soon thereafter as practical, Landlord shall provide Tenant notice of Landlord’s estimate of the Operating Expenses for the ensuing Lease Year or
applicable portion thereof. On or before the first day of each month during the ensuing Lease Year or applicable portion thereof, beginning on the Commencement Date, Tenant shall pay to Landlord Tenant’s Operating Cost Share of the portion of
such estimated Operating Expenses allocable (on a prorata basis) to such month; provided, however, that if such notice is not given in the last month of a Lease Year, Tenant shall continue to pay on the basis of the prior year’s
estimate, if any, until the month after such notice is given. If at any time or times it appears to Landlord that the actual Operating Expenses will vary from Landlord’s estimate by more than five percent (5%), Landlord may, by notice to
Tenant, revise its estimate for such year and subsequent payments by Tenant for such year shall be based upon such revised estimate. 
 5.4
Final Accounting For Lease Year. Within ninety (90) days after the close of each Lease Year, or as soon after such 90-day period as practicable, Landlord shall deliver to Tenant a statement of Tenant’s Operating Cost Share of the
Operating Expenses for such Lease Year prepared by Landlord from Landlord’s books and records, which statement shall be final and binding on Landlord and Tenant. If on the basis of such statement Tenant owes an amount that is more or less than
the estimated payments for such calendar year previously made by Tenant, Tenant or Landlord, as the case may be, shall pay the deficiency to the other party within thirty (30) days after delivery of the statement. Failure or inability of
Landlord to deliver the annual statement within such ninety (90) day period shall not impair or constitute a waiver of Tenant’s obligation to pay Operating Expenses, or cause Landlord to incur any liability for damages. Notwithstanding the
foregoing, Tenant may inspect backup documentation of Landlord for purposes of verifying the information contained in Landlord’s statement of Operating Expenses. 
 5.5 Proration. If the Commencement Date falls on a day other than the first day of a Lease Year or if this Lease terminates on a day other than the last day of a Lease Year, the amount of Tenant’s
Operating Cost Share payable by Tenant applicable to such first and last partial Lease Year shall be prorated on the basis which the number of days during such Lease Year in which this Lease is in effect bears to 365. The termination of this Lease
shall not affect the obligations of Landlord and Tenant pursuant to Section 5.4 to be performed after such termination. 
  

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	6.	UTILITIES 

 6.1 Payment. Commencing with the
Commencement Date and thereafter throughout the term of this Lease, Tenant shall pay, before delinquency, all charges for water, gas, heat, light, electricity, power, sewer, telephone, alarm system, janitorial and other services or utilities
supplied to or consumed in or upon the Premises, including any taxes on such services and utilities. It is the intention of the parties that all such services shall be separately metered to the Premises. In the event that any of such services
supplied to the Premises are not separately metered, then the amount thereof shall be an item of Operating Expenses and shall be paid as provided in Article 5. 
 6.2 Interruption. There shall be no abatement of rent or other charges required to be paid hereunder and Landlord shall not be liable in damages or otherwise for interruption or failure of any service or
utility furnished to or used in the Premises because of accident, making of repairs, alterations or improvements, severe weather, difficulty or inability in obtaining services or supplies, labor difficulties or any other cause. 
  

	7.	ALTERATIONS 

 7.1 Right To Make Alterations.
Tenant shall make no alterations, additions or improvements to the Premises, other than interior non-structural alterations costing less than Ten Thousand Dollars ($10,000.00) in each instance (“Permitted Alterations”), without the
prior written consent of Landlord. All such alterations, additions and improvements shall be completed with due diligence in a first-class workmanlike manner and in compliance with plans and specifications approved in writing by Landlord (except
that Landlord’s approval is not required for Permitted Alterations) and all applicable laws, ordinances, rules and regulations. In connection with any alterations, additions or improvements (including, but not limited to, any construction or
installation of furnishings, fixtures or equipment) constructed or installed by Tenant and costing in excess of Fifty Thousand Dollars ($50,000.00) in the aggregate during any twelve (12) month period, Tenant shall engage only union contractors
for such work and shall require all such contractors engaged by Tenant, and all of their subcontractors, to use only union labor on or in connection with such work. 
 7.2 Title To Alterations. All alterations, additions and improvements installed in, on or about the Premises shall be part of the Building and the property of Landlord, unless Landlord elects to require Tenant
to remove the same upon the termination of this Lease; provided, however, that the foregoing shall not apply to Tenant’s movable furniture, trade fixtures, equipment or furniture. In no event shall Tenant be required to remove the Tenant
Improvements. 
 7.3 Tenant Fixtures. Notwithstanding the provisions of Sections 7.1 and 7.2, Tenant may install, remove and reinstall
equipment and trade fixtures without Landlord’s prior written consent, except that any fixtures which are affixed to the Premises or which affect the exterior or structural portions of the Building shall require Landlord’s written
approval. Subject to Section 17.20, the foregoing sentence shall apply to Tenant’s signs, logos and insignia, all of which Tenant shall have the right to place and remove and replace solely with Landlord’s prior written consent as to
location, size and composition. Tenant shall immediately repair any damage caused by installation and removal of fixtures and equipment under this Section 7.3. 
 7.4 No Liens. Tenant shall at all times keep the Premises free from all liens and claims of any contractors, subcontractors, materialmen, suppliers or any other parties employed either directly or indirectly by
Tenant in construction work on the Premises. Tenant may contest any claim of lien, but only if, prior to such contest, Tenant either (i) posts security in the amount of the claim, plus estimated costs and interest, or (ii) records a bond
of a responsible corporate surety in such amount as may be required to release the lien from the Premises. Tenant shall indemnify, defend and hold Landlord harmless against any and all liability, loss, damage, cost and other expenses, including,
without limitation, reasonable attorneys’ fees, arising out of claims of any lien for work performed or materials or supplies furnished at the request of Tenant or persons claiming under Tenant. 
  

	8.	MAINTENANCE AND REPAIRS 

 8.1 Landlord’s
Work. Landlord shall repair and maintain or cause to be repaired and maintained those portions of the Building outside of the Premises, the common areas of the 

  

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Property, and the roof, exterior walls and other structural portions of the Building, items that are properly categorized as capital expenses and the
Building systems (excluding the HVAC and related mechanical systems serving the Premises exclusively). The cost of all work performed by Landlord under this Section 8.1 shall be an Operating Expense hereunder, except to the extent such work
(i) is required due to the negligence of Landlord or any other tenant of the Building, (ii) is a service to a specific tenant or tenants, other than Tenant, to the extent that Landlord has received or has the right to receive full
reimbursement, (iii) is a capital expense not includible as an Operating Expense under Section 5.2 hereof, or (iv) is required due to the negligence or willful misconduct of Tenant or its agents, employees or invitees (in which event
Tenant shall bear the full cost of such work pursuant to the indemnification provided in Section 10.6 hereof). Tenant knowingly and voluntarily waives the right to make repairs at Landlord’s expense, or to offset the cost thereof against
rent, under any law, statute, regulation or ordinance now or hereafter in effect. 
 8.2 Tenant’s Obligation For Maintenance.

 (a) Good Order. Condition And Repair. Subject to Tenant’s rights with respect to latent defects under
Section 2.4, by accepting possession of the Premises, Tenant acknowledges that the Premises are in good and sanitary order, condition and repair. Except as provided in Section 8.1 hereof, Tenant at its sole cost and expense shall keep and
maintain in good and sanitary order, condition and repair the Premises and every part thereof, wherever located, including but not limited to the signs, interior, the face of the ceiling over Tenant’s floor space, HVAC equipment and related
mechanical systems serving the Premises (for which equipment and systems Tenant shall enter into a service contract with a person or entity designated or reasonably approved by Landlord), all doors, door checks, windows, plate glass, door fronts,
exposed plumbing and sewage and other utility facilities, fixtures, lighting, wall surfaces, floor surfaces and ceiling surfaces and all other interior repairs, foreseen and unforeseen, as required. If the HVAC system serving the Premises
exclusively is under warranty, Landlord will assign the warranty to Tenant. 
 (b) Landlord’s Remedy. If Tenant,
after notice from Landlord and expiration of the applicable cure period , fails to make or perform promptly any repairs or maintenance which are the obligation of Tenant hereunder, Landlord shall have the right, but shall not be required, to enter
the Premises and make the repairs or perform the maintenance necessary to restore the Premises to good and sanitary order, condition and repair. Immediately on demand from Landlord, the cost of such repairs shall be due and payable by Tenant to
Landlord. 
 (c) Condition Upon Surrender. At the expiration or sooner termination of this Lease, Tenant shall
surrender the Premises, including any additions, alterations and improvements thereto, broom clean, in good and sanitary order, condition and repair, ordinary wear and tear, damage from earthquakes, and casualties that standard all-risk property
insurance insures against, and Condemnation and Hazardous Materials that are not attributable in any way to Tenant excepted, first, however, removing all goods and effects of Tenant and any and all fixtures and items required to be removed or
specified to be removed at Landlord’s election pursuant to this Lease, and repairing any damage caused by such removal. Tenant expressly waives any and all interest in any personal property and trade fixtures not removed from the Premises by
Tenant at the expiration or termination of this Lease, agrees that any such personal property and trade fixtures may, at Landlord’s election, be deemed to have been abandoned by Tenant, and authorizes Landlord (at its election and without
prejudice to any other remedies under this Lease or under applicable law) to remove and either retain, store or dispose of such property at Tenant’s cost and expense, and Tenant waives all claims against Landlord for any damages resulting from
any such removal, storage, retention or disposal. 
  

	9.	USE OF PREMISES 

 9.1 Permitted Use. Tenant
shall use the Premises solely for laboratory, research and development facility and related uses, and for no other purpose. 
 9.2
[Reserved.]. 
 9.3 No Nuisance. Tenant shall not use the Premises for or carry on or permit upon the Premises or any part thereof any
offensive, noisy or dangerous trade, business, manufacture, 

  

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occupation, odor or fumes, or any nuisance or anything against public policy, nor interfere with the rights or business of any other tenants or of Landlord
in the Building or the Property, nor commit or allow to be committed any waste in, on or about the Premises, nor make any other unreasonable use of the Premises. Tenant shall not do or permit anything to be done in or about the Premises, nor bring
nor keep anything therein, which will in any way cause the Premises to be uninsurable with respect to the insurance required by this Lease or with respect to standard fire and extended coverage insurance with vandalism, malicious mischief and riot
endorsements and any other available endorsement, provided that Tenant must reimburse Landlord for any endorsement that Landlord procures specifically to insure against risks arising from Tenant’s activities. 
 9.4 Compliance With Laws. Tenant shall not use the Premises or permit the Premises to be used in whole or in part for any purpose or use that is
in violation of any applicable laws, ordinances, regulations or rules of any governmental agency or public authority. Tenant shall keep the Premises equipped with all safety appliances required by law, ordinance or insurance on the Premises, or any
order or regulation of any public authority because of Tenant’s particular use of the Premises. Tenant shall procure all licenses and permits required for use of the Premises. Tenant shall use the Premises in strict accordance with all
applicable ordinances, rules, laws and regulations and shall comply with all requirements of all governmental authorities now in force or which may hereafter be in force pertaining to the use of the Premises by Tenant, including, without limitation,
regulations applicable to noise, water, soil and air pollution, and making such nonstructural alterations and additions thereto as may be required from time to time by such laws, ordinances, rules, regulations and requirements of governmental
authorities or insurers of the Premises (collectively, “Requirements”) because of Tenant’s construction of improvements in or other particular use of the Premises. Any structural alterations or additions required from time to
time by applicable Requirements because of Tenant’s construction of improvements in or other particular use of the Premises shall, at Landlord’s election, either (i) be made by Tenant, at Tenant’s sole cost and expense, in
accordance with the procedures and standards set forth in Section 7.1 for alterations by Tenant, or (ii) be made by Landlord at Tenant’s sole cost and expense, in which event Tenant shall pay to Landlord as additional rent, within
thirty (30) days after demand by Landlord, an amount equal to all costs incurred by Landlord in connection with such alterations or additions. The judgment of any court, or the admission by Tenant in any proceeding against Tenant, that Tenant
has violated any law, statute, ordinance or governmental rule, regulation or requirement shall be conclusive of such violation as between Landlord and Tenant. 
 9.5 Liquidation Sales. Tenant shall not conduct or permit to be conducted any auction, bankruptcy sale, liquidation sale, or going out of business sale, in, upon or about the Premises or the Property, whether
said auction or sale be voluntary, involuntary or pursuant to any assignment for the benefit of creditors, or pursuant to any bankruptcy or other insolvency proceeding. 
 9.6 Environmental Matters. Without limiting the generality of Tenant’s obligations set forth in Section 9.4 of this Lease: 
 (a) Tenant shall not cause or permit any hazardous or toxic substance or hazardous waste (as defined in any federal, state or local law,
ordinance or regulation applicable to such substances or wastes) (“Hazardous Materials”) to be brought upon, kept, stored or used on or about the Property by Tenant, its agents, employees, suppliers, customers or invitees without
the prior written consent of Landlord, which may not be unreasonably withheld or delayed, provided, however, that Tenant may, on an emergency basis, with notice to Landlord but without Landlord’s prior consent, bring, keep, use or store
Hazardous Materials on the Property, provided further that (a) Tenant may bring, keep, use or store such Hazardous Materials only for two days if Landlord does not consent to such Hazardous Materials and (b) the quantity and general type
of such Hazardous Materials must be consistent with Hazardous Materials for which Tenant has previously obtained Landlord’s consent. 
 (b) Tenant shall comply with all applicable laws, rules, regulations, orders, permits, licenses and operating plans of any governmental authority with respect to the receipt, use, handling, generation, transportation,
storage, treatment, release and/or disposal of hazardous or toxic substances or wastes in the course of or in connection with the conduct of Tenant’s business on the Property, and shall provide Landlord with copies of any and all permits,
licenses, 

  

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registrations and other similar documents that authorize Tenant to conduct any such activities in connection with Tenant’s use of the Property.

 (c) Tenant shall indemnify, defend and hold Landlord harmless from and against any and all claims, losses, damages,
liabilities, costs, legal fees and expenses of any sort arising out of or relating to (i) any failure by Tenant to comply with any provisions of subparagraph (a) or (b) above, or (ii) any receipt, use, handling, generation,
transportation, storage, treatment, release and/or disposal of any hazardous or toxic substances or wastes on or about the Property by Tenant or any agent, employee, supplier or licensee of Tenant and in connection with Tenant’s use or
occupancy of the Property or as a result of any intentional or negligent acts or omissions of Tenant or of any agent or employee of Tenant. 
 (d) Landlord shall indemnify, defend and hold Tenant harmless from and against any and all claims, losses, damages, liabilities, costs, legal fees and expenses of any sort arising out of or relating to (i) the
presence on the Property of any hazardous or toxic substances or wastes present on the Property as of the Commencement Date (except to the extent their presence is the result of any intentional or negligent acts or omissions of Tenant or of any
agent or employee of Tenant), and/or (ii) any unauthorized release into the environment of hazardous or toxic substances or wastes to the extent they result from the negligence of or willful misconduct or omission by Landlord or its agents or
employees. To Landlord’s actual knowledge, (a) no Hazardous Material is present on the Property or the soil, surface water or groundwater thereof, (b) no underground storage tanks are present on the Property, and (c) no action,
proceeding or claim is pending or threatened regarding the Property concerning any Hazardous Material or pursuant to any environmental law. 
 (e) The provisions of this Section 9.6 shall survive the termination of this Lease. 
  

	10.	INSURANCE AND INDEMNITY 

 10.1 Liability
Insurance. Tenant shall procure and maintain in full force and effect at all times during the term of this Lease, at Tenant’s cost and expense, comprehensive public liability and property damage insurance to protect against any liability to
the public, or to any invitee of Tenant or Landlord, arising out of or related to the use of or resulting from any accident occurring in, upon or about the Premises, with limits of liability of not less than (i) Three Million Dollars
($3,000,000.00) per occurrence for bodily injury, personal injury and death, and (ii) Five Hundred Thousand Dollars ($500,000.00) for property damage or a combined single limit of Bodily Injury and property damage insurance of not less than
Five Million Dollars ($5,000,000.00). Such insurance shall name Landlord and its general partners and its property manager as additional insureds thereunder. The amount of such insurance shall not be construed to limit any liability or obligation of
Tenant under this Lease. 
 10.2 Quality Of Policies And Certificates. All policies of insurance required hereunder shall be issued by
responsible insurers and shall be written as primary policies not contributing with and not in excess of any coverage that Landlord may carry. Tenant shall deliver to Landlord copies of policies or certificates of insurance showing that said
policies are in effect. The coverage provided by such policies shall include the clause or endorsement referred to in Section 10.4. If Tenant fails to acquire, maintain or renew any insurance required to be maintained by it under this Article
10 or to pay the premium therefor, then Landlord, at its option and in addition to its other remedies, but without obligation so to do, may procure such insurance, and any sums expended by it to procure any such insurance shall be repaid upon
demand, with interest as provided in Section 3.2 hereof. Tenant shall obtain written undertakings from each insurer under policies required to be maintained by it to notify all insureds thereunder at least thirty (30) days prior to
cancellation, non-renewal or reduction of coverage. 
 10.3 Workers’ Compensation. Tenant shall maintain in full force and effect
during the term of this Lease workers’ compensation insurance covering all of Tenant’s employees working on the Premises to the extent required by applicable law. Tenant shall maintain in full force and effect during the term of this Lease
employer’s liability insurance with limits of no less than $500,000.00 each accident, $500,000.00 each employee for disease, and $500,000.00 policy aggregate for disease. 
  

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 10.4 Waiver Of Subrogation. To the extent permitted by law and without affecting the coverage
provided by insurance required to be maintained hereunder, Landlord and Tenant each waive any right to recover against the other for (i) damage to property, (ii) damage to the Premises or any part thereof, or (iii) claims arising by
reason of any of the foregoing, but only to the extent that any of the foregoing damages and claims under subparts (i)-(iii) hereof are covered, and only to the extent of such coverage, by casualty insurance actually carried or required to be
carried hereunder by either Landlord or Tenant or that would normally be covered by all-risk property insurance. This provision is intended to waive fully, and for the benefit of each party, any rights and claims which might give rise to a right of
subrogation in any casualty insurance carrier. Each party shall procure a clause or endorsement on any casualty insurance policy required under this Article 10 denying to the insurer rights of subrogation against the other party to the extent rights
have been waived by the insured prior to the occurrence of injury or loss. Coverage provided by insurance maintained by Tenant under this Article 10 shall not be limited, reduced or diminished by virtue of the subrogation waiver herein contained.
All of Landlord’s and Tenant’s repair and indemnity obligations under this Lease shall be subject to the waivers contained in this paragraph. 
 10.5 Increase In Premiums. Tenant shall do all acts and pay all expenses necessary to insure that the Premises are not used for purposes prohibited by any applicable fire insurance, and that Tenant’s use
of the Premises complies with all requirements necessary to obtain any such insurance. If Tenant uses or permits the Premises to be used in a manner which increases the existing rate of any insurance on the Premises carried by Landlord, Tenant shall
pay the amount of the increase in premium caused thereby, and Landlord’s costs of obtaining other replacement insurance policies, including any increase in premium, within ten (10) days after demand therefor by Landlord. 
 10.6 Indemnification. 
 (a) Tenant shall indemnify, defend and hold Landlord, its partners, shareholders, officers, directors, affiliates, agents, employees and contractors, harmless from any and all liability for injury to or death of any person, or loss of or
damage to the property of any person, and all actions, claims, demands, costs (including, without limitation, reasonable attorneys’ fees), damages or expenses of any kind arising therefrom which may be brought or made against Landlord or which
Landlord may pay or incur by reason of the use, occupancy and enjoyment of the Premises by Tenant or any invitees, sublessees, licensees, assignees, employees, agents or contractors of Tenant or holding under Tenant from any cause whatsoever other
than negligence or willful misconduct or omission by Landlord, its agents or employees. Landlord, its partners, shareholders, officers, directors, affiliates, agents, employees and contractors shall not be liable for, and Tenant hereby waives all
claims against such persons for, damages to goods, wares and merchandise in or upon the Premises, or for injuries to Tenant, its agents or third persons in or upon the Premises, from any cause whatsoever other than negligence or willful misconduct
or omission by Landlord, its agents or employees. Tenant shall give prompt notice to Landlord of any casualty or accident in, on or about the Premises. 
 (b) Notwithstanding anything to the contrary in Section 10.6(a), Landlord shall not be released from or indemnified against, and Landlord shall indemnify, defend and hold Tenant, its partners, shareholders,
officers, directors, affiliates, agents, employees and contractors, harmless from any and all liability for injury to or death of any person or loss of or damage to the property of any person, and all actions, claims, demands, costs (including,
without limitation, reasonable attorneys’ fees), damages or expenses of any kind arising therefrom which may be brought or made against Tenant or which Tenant may pay or incur, to the extent such liabilities or other matters arise by reason of
any negligence or willful misconduct or omission by Landlord, its agents or employees. 
 10.7 Blanket Policy. Any policy required to
be maintained hereunder may be maintained under a so-called “blanket policy” insuring other parties and other locations so long as the amount of insurance required to be provided hereunder is not thereby diminished. 
  

	11.	SUBLEASE AND ASSIGNMENT 

 11.1 Assignment And
Sublease Of Premises. Tenant shall not have the right or power to assign its interest in this Lease, or make any sublease, nor shall any interest of Tenant under 

  

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this Lease be assignable involuntarily or by operation of law, without on each occasion obtaining the prior written consent of Landlord, which consent shall
not be unreasonably withheld. Any purported sublease or assignment of Tenant’s interest in this Lease requiring but not having received Landlord’s consent thereto shall be void. Without limiting the generality of the foregoing, Landlord
may withhold consent to any proposed subletting or assignment solely on the ground that the use by the proposed subtenant or assignee is reasonably likely to be incompatible with Landlord’s use of the balance of the Building or Property.
Notwithstanding anything above in this Section 11.1, (a) a transfer of Tenant’s interest in this Lease that occurs as a result of a merger, consolidation, nonbankruptcy reorganization or (b) the transfer by Tenant of its interest
in this Lease to a purchaser of substantially all the assets of Tenant, provided that the transaction described in the foregoing clauses (a) and (b) is not consummated primarily to transfer this Lease, shall not be considered an assignment
of this Lease if the net worth of Tenant’s successor-in-interest to this Lease on the date of the transfer is no less than Tenant’s net worth the day before the transfer; provided however, that if Tenant does not notify Landlord in writing
of the proposed transfer at least ten (10) days before the transfer is to occur, the transfer shall be deemed to be an assignment of this Lease. Notwithstanding anything above in this Section 11.1, a sublease or assignment of this Lease to
an entity that owns more than fifty-one percent (51%) of the outstanding equity securities of Tenant or that is a wholly-owned subsidiary of Tenant shall not be considered a sublease or assignment for purposes of this Section 11.1 provided
that Tenant notifies Landlord in writing of the proposed sublease or assignment at least ten (10) days before the transfer is to occur. 
 11.2 Rights Of Landlord. 
 (a) Consent by Landlord to one or more assignments of this Lease, or to one or
more sublettings of the Premises, or collection of rent by Landlord from any assignee or sublessee, shall not operate to exhaust Landlord’s rights under this Article 11, nor constitute consent to any subsequent assignment or subletting. No
assignment of Tenant’s interest in this Lease and no sublease shall relieve Tenant of its obligations hereunder, notwithstanding any waiver or extension of time granted by Landlord to any assignee or sublessee, or the failure of Landlord to
assert its rights against any assignee or sublessee, and regardless of whether Landlord’s consent thereto is given or required to be given hereunder. In the event of a default by any assignee, sublessee or other successor of Tenant in the
performance of any of the terms or obligations of Tenant under this Lease, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against any such assignee, sublessee or other successor. In addition, Tenant
immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any subletting of all or a part of the Premises as permitted under this Lease, and Landlord, as Tenant’s assignee and as
attorney-in-fact for Tenant, or any receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that Tenant shall have the right to collect such rent
until the occurrence of a default which has not been cured in the applicable cure period. 
 (b) Upon any assignment of
Tenant’s interest in this Lease, Tenant shall pay to Landlord, within ten (10) days after receipt thereof by Tenant from time to time, one-half ( 1/2) of all cash sums and other economic considerations received by Tenant in connection with or as a result of such assignment, after first deducting therefrom (i) any costs incurred by Tenant for
leasehold improvements (including, but not limited to, third-party architectural and space planning costs) in the Premises in connection with such assignment, amortized over the remaining term of this Lease, and (ii) any reasonable real estate
commissions and/or reasonable attorneys’ fees incurred by Tenant in connection with such assignment. 
 (c) Upon
any sublease of all or any portion of the Premises, Tenant shall pay to Landlord, within ten (10) days after receipt thereof by Tenant from time to time, one-half ( 1/2) of all cash sums and other economic considerations received by Tenant in connection with or as a result of such sublease, after first deducting therefrom (i) the minimum
rental and Operating Cost Share due hereunder for the corresponding period, prorated (on the basis of the average per-square-foot cost paid by Tenant for the entire Premises for the applicable period under this Lease) to reflect the size of the
subleased portion of the Premises, (ii) any costs incurred by Tenant for leasehold improvements in the subleased portion of the Premises (including, but not limited to, third-party architectural and space planning costs) for the specific
benefit of the sublessee in connection with such sublease, amortized over the remaining term of this Lease, 

  

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(iii) any reasonable real estate commissions and/or reasonable attorneys’ fees incurred by Tenant in connection with such sublease, amortized over the
term of such sublease, and (iv) any costs incurred by Tenant for leasehold improvements in the subleased portion of the Premises not for the specific benefit of the sublessee, amortized over the term of this Lease. 
  

	12.	RIGHT OF ENTRY AND QUIET ENJOYMENT 

 12.1 Right
Of Entry. Landlord and its authorized representatives shall have the right to enter the Premises at any time during the term of this Lease during normal business hours and upon not less than twenty-four (24) hours prior notice, except in
the case of emergency (in which event no notice shall be required and entry may be made at any time), for the purpose of inspecting and determining the condition of the Premises or for any other proper purpose including, without limitation, to make
repairs, replacements or improvements which Landlord may deem necessary, to show the Premises to prospective purchasers, to show the Premises to prospective tenants, and to post notices of nonresponsibility. Landlord shall not be liable for
inconvenience, annoyance, disturbance, loss of business, quiet enjoyment or other damage or loss to Tenant by reason of making any repairs or performing any work upon the Premises, the Building or the Property, and the obligations of Tenant under
this Lease shall not thereby be affected in any manner whatsoever, provided, however, Landlord shall use reasonable efforts to minimize the inconvenience to Tenant’s normal business operations caused thereby and shall comply with
Tenant’s reasonable security, safety, laboratory and operational procedures. 
 12.2 Quiet Enjoyment. Landlord covenants that
Tenant, upon paying the rent and performing its obligations hereunder within applicable notice and cure periods and subject to all the terms and conditions of this Lease, shall peacefully and quietly have, hold and enjoy the Premises throughout the
term of this Lease, or until this Lease is terminated as provided by this Lease. 
  

	13.	CASUALTY AND TAKING 

 13.1 Termination Or
Reconstruction. If during the term of this Lease the entire Premises or entire Building, or any substantial part of either, (i) is damaged materially by fire or other casualty or by action of public or other authority in consequence
thereof, (ii) is taken by eminent domain or by reason of any public improvement or condemnation proceeding, or in any manner by exercise of the right of eminent domain (including any transfer in avoidance of an exercise of the power of eminent
domain), or (iii) receives irreparable damage by reason of anything lawfully done under color of public or other authority, this Lease shall terminate as to the entire Premises at Landlord’s election by written notice given to Tenant
within sixty (60) days after the damage or taking has occurred. If Landlord does not elect to terminate this Lease as hereinabove provided, Landlord shall repair any such damage and restore the Premises (to the extent of Landlord’s work
therein under Section 2.4 and Exhibit C) and the Building as nearly as reasonably possible to the condition existing before the damage or taking. Notwithstanding the foregoing paragraph, if the Premises are damaged by any peril and
Landlord does not terminate this Lease, then Tenant shall have the option to terminate this Lease if the Premises cannot be, or are not in fact, fully restored by Landlord to their prior condition within two hundred forty (240) days after the
damage. 
 13.2 Tenant’s Rights. If any portion of the Premises is so taken by condemnation, Tenant may elect to terminate this
Lease if the portion of the Premises taken is of such extent and nature as substantially to handicap, impede or permanently impair Tenant’s use of the balance of the Premises. Tenant must exercise its right to terminate by giving notice to
Landlord within thirty (30) days after the nature and extent of the taking have been finally determined. If Tenant elects to terminate this Lease, Tenant shall also notify Landlord of the date of termination, which date shall not be earlier
than thirty (30) days nor later than ninety (90) days after Tenant has notified Landlord of its election to terminate, except that this Lease shall terminate on the date of taking if the date of taking falls on any date before the date of
termination designated by Tenant. 
 13.3 Lease To Remain In Effect. If neither Landlord nor Tenant terminates this Lease as
hereinabove provided, this Lease shall continue in full force and effect, except that minimum monthly rental and Tenant’s Operating Cost Share shall abate to the extent Tenant’s use of the Premises is impaired for any period that any
portion of the Premises is unusable or inaccessible because of a casualty or taking hereinabove described. Each party waives the provisions of Code 

  

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of Civil Procedure Section 1265.130, allowing either party to petition the Superior Court to terminate this Lease in the event of a partial condemnation
of the Premises. 
 13.4 Reservation Of Compensation. Landlord reserves, and Tenant waives and assigns to Landlord, all rights to any
award or compensation for damage to the Premises, Building, Property and the leasehold estate created hereby, accruing by reason of any taking in any public improvement, condemnation or eminent domain proceeding or in any other manner by exercise of
the right of eminent domain or of anything lawfully done by public authority, except that Tenant shall be entitled to any and all compensation or damages paid for or on account of Tenant’s moving expenses, trade fixtures, equipment and any
leasehold improvements in the Premises, the cost of which was borne by Tenant, but only to the extent of the then remaining unamortized value of such improvements computed on a straight-line basis over the term of this Lease. Tenant covenants to
deliver such further assignments of the foregoing as Landlord may from time to time request. 
 13.5 Restoration Of Fixtures. If
Landlord repairs or causes repair of the Premises after such damage or taking, Tenant at its sole expense shall repair and replace promptly all fixtures, equipment and other property of Tenant located at, in or upon the Premises and all additions,
alterations and improvements and all other items installed or paid for by Tenant under this Lease that were damaged or taken, so as to restore the same to a condition substantially equal to that which existed immediately prior to the damage or
taking. Tenant shall have the right to make modifications to the Premises, fixtures and improvements, subject to the prior written approval of Landlord. In its review of Tenant’s plans and specifications, Landlord may take into consideration
the effect of the proposed modifications on the exterior appearance, the structural integrity and the mechanical and other operating systems of the Building. 
  

	14.	DEFAULT 

 14.1 Events Of Default. The
occurrence of any of the following shall constitute an event of default on the part of Tenant: 
 (a) Abandonment.
Abandonment of the Premises. Tenant waives any right Tenant may have to notice under Section 1951.3 of the California Civil Code, the terms of this subsection (a) being deemed such notice to Tenant as required by said Section 1951.3;

 (b) Nonpayment. Failure to pay, when due, any amount payable to Landlord hereunder, such failure continuing for a
period of five (5) days after written notice of such failure; provided, however, that any such notice shall be in lieu of, and not in addition to, any notice required under California Code of Civil Procedure Section 1161 et
seg., as amended from time to time; 
 (c) Other Obligations. Failure to perform any obligation, agreement or
covenant under this Lease other than those matters specified in subsection (b) hereof, such failure continuing for thirty (30) days after written notice of such failure, or, if it is not possible to cure such default within thirty
(30) days, failure to commence cure within said thirty (30) day period and thereafter to proceed diligently to complete cure; provided, however, that any such notice shall be in lieu of, and not in addition to, any notice required
under California Code of Civil Procedure Section 1161 et seg., as amended from time to time; 
 (d)
General Assignment. A general assignment by Tenant for the benefit of creditors; 
 (e) Bankruptcy. The filing
of any voluntary petition in bankruptcy by Tenant, or the filing of an involuntary petition by Tenant’s creditors, which involuntary petition remains undischarged for a period of thirty (30) days. In the event that under applicable law the
trustee in bankruptcy or Tenant has the right to affirm this Lease and continue to perform the obligations of Tenant hereunder, such trustee or Tenant shall, in such time period as may be permitted by the bankruptcy court having jurisdiction, cure
all defaults of Tenant hereunder outstanding as of the date of the affirmance of this Lease and provide to Landlord such adequate assurances as may be necessary to ensure Landlord of the continued performance of Tenant’s obligations under this
Lease. Specifically, but without limiting the generality of the foregoing, such adequate assurances must include assurances that the Premises continue to be operated only for the use 

  

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permitted hereunder. The provisions hereof are to assure that the basic understandings between Landlord and Tenant with respect to Tenant’s use of the
Premises and the benefits to Landlord therefrom are preserved, consistent with the purpose and intent of applicable bankruptcy laws; 
 (f) Receivership. The employment of a receiver appointed by court order to take possession of substantially all of Tenant’s assets or the Premises, if such receivership remains undissolved for a period of thirty (30) days;

 (g) Attachment. The attachment, execution or other judicial seizure of all or substantially all of Tenant’s
assets or the Premises, if such attachment or other seizure remains undismissed or undischarged for a period of thirty (30) days after the levy thereof; 
 (h) Insolvency. The admission by Tenant in writing of its inability to pay its debts as they become due, the filing by Tenant of a
petition seeking any reorganization or arrangement, composition, readjustment, liquidation, dissolution or similar relief under any present or future statute, law or regulation, the filing by Tenant of an answer admitting or failing timely to
contest a material allegation of a petition filed against Tenant in any such proceeding or, if within thirty (30) days after the commencement of any proceeding against Tenant seeking any reorganization or arrangement, composition, readjustment,
liquidation, dissolution or similar relief under any present or future statute, law or regulation, such proceeding shall not have been dismissed; or 
 (i) Subordination. Failure to execute and deliver a document requested of Tenant under Section 15.1 within ten (10) business days after the request for such document from Landlord. 
 14.2 Remedies Upon Tenant’s Default. 
 (a) Upon the occurrence of any event of default described in Section 14.1 hereof, Landlord, in addition to and without prejudice to any other rights or remedies it may have, shall have the immediate right to
re-enter the Premises or any part thereof and repossess the same, expelling and removing therefrom all persons and property (which property may be stored in a public warehouse or elsewhere at the cost and risk of and for the account of Tenant),
using such force as may be necessary to do so (as to which Tenant hereby waives any claim for loss or damage that may thereby occur). In addition to or in lieu of such re-entry, and without prejudice to any other rights or remedies it may have,
Landlord shall have the right either (i) to terminate this Lease and recover from Tenant all damages incurred by Landlord as a result of Tenant’s default, as hereinafter provided, or (ii) to continue this Lease in effect and recover
rent and other charges and amounts as they become due. 
 (b) Even if Tenant has breached this Lease or abandoned the
Premises, this Lease shall continue in effect for so long as Landlord does not terminate Tenant’s right to possession under subsection (a) hereof and Landlord may enforce all of its rights and remedies under this Lease, including the right
to recover rent as it becomes due, and Landlord, without terminating this Lease, may exercise all of the rights and remedies of a lessor under California Civil Code Section 1951.4 (lessor may continue lease in effect after lessee’s breach
and abandonment and recover rent as it becomes due, if lessee has right to sublet or assign, subject only to reasonable limitations), or any successor Code section. Acts of maintenance, preservation or efforts to relet the Premises or the
appointment of a receiver upon application of Landlord to protect Landlord’s interests under this Lease shall not constitute a termination of Tenant’s right to possession. 
 (c) If Landlord terminates this Lease pursuant to this Section 14.2, Landlord shall have all of the rights and remedies of a landlord
provided by Section 1951.2 of the Civil Code of the State of California, or any successor Code section, which remedies include Landlord’s right to recover from Tenant (i) the worth at the time of award of the unpaid rent and
additional rent which had been earned at the time of termination, (ii) the worth at the time of award of the amount by which the unpaid rent and additional rent which would have been earned after termination until the time of award exceeds the
amount of such rental loss that Tenant proves could have been reasonably avoided, (iii) the worth at the time of award of the amount by which the unpaid rent and additional rent for the balance of the term after the time of award exceeds the
amount of such rental loss that Tenant proves could be reasonably avoided, and (iv) 

  

 - 16 - 

 
any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this
Lease or which in the ordinary course of things would be likely to result therefrom, including, but not limited to, the cost of recovering possession of the Premises, expenses of reletting, including necessary repair, renovation and alteration of
the Premises, reasonable attorneys’ fees, and other reasonable costs. The “worth at the time of award” of the amounts referred to in clauses (i) and (ii) above shall be computed by allowing interest at ten percent
(10%) per annum from the date such amounts accrued to Landlord. The “worth at the time of award” of the amounts referred to in clause (iii) above shall be computed by discounting such amount at one percentage point above the
discount rate of the Federal Reserve Bank of San Francisco at the time of award. 
 14.3 Remedies Cumulative. All rights, privileges
and elections or remedies of Landlord contained in this Article 14 are cumulative and not alternative to the extent permitted by law and except as otherwise provided herein. 
  

	15.	SUBORDINATION, ATTORNMENT AND SALE 

 15.1
Subordination To Mortgage. This Lease, and any sublease entered into by Tenant under the provisions of this Lease, shall be subject and subordinate to any ground lease, mortgage, deed of trust, sale/leaseback transaction or any other
hypothecation for security now or hereafter placed upon the Building, the Property, or both, and the rights of any assignee of Landlord or of any ground lessor, mortgagee, trustee, beneficiary or leaseback lessor under any of the foregoing, and to
any and all advances made on the security thereof and to all renewals, modifications, consolidations, replacements and extensions thereof. If any mortgagee, trustee, beneficiary, ground lessor, sale/leaseback lessor or assignee elects to have this
Lease be an encumbrance upon the Property prior to the lien of its mortgage, deed of trust, ground lease or leaseback lease or other security arrangement and gives notice thereof to Tenant, this Lease shall be deemed prior thereto, whether this
Lease is dated prior or subsequent to the date thereof or the date of recording thereof. Tenant, and any sublessee, shall execute such documents as may reasonably be requested by any mortgagee, trustee, beneficiary, ground lessor, sale/leaseback
lessor or assignee to evidence the subordination herein set forth or to make this Lease prior to the lien of any mortgage, deed of trust, ground lease, leaseback lease or other security arrangement, as the case may be. Upon any default by Landlord
in the performance of its obligations under any mortgage, deed of trust, ground lease, leaseback lease or assignment, Tenant (and any sublessee) shall, notwithstanding any subordination hereunder, attorn to the mortgagee, trustee, beneficiary,
ground lessor, leaseback lessor or assignee thereunder upon demand and become the tenant of the successor in interest to Landlord, at the option of such successor in interest, and shall execute and deliver any instrument or instruments confirming
the attornment herein provided for. Notwithstanding the foregoing, (i) Landlord shall use its best efforts to obtain before the Commencement Date from Northwest Mutual Life Insurance Company an executed Non-Disturbance and Attornment Agreement
in favor of Tenant substantially the form attached hereto as Exhibit E (Landlord acknowledges that Tenant may require commercially reasonable revisions to such form and Landlord will make reasonable efforts to assist Tenant in obtaining such
revisions); and (ii) the subordination of this Lease to a ground lease or instrument of security shall be conditioned on Tenant’s receipt from any such ground lessors or lenders a written agreement providing for recognition of
Tenant’s interests under this Lease in the event of a foreclosure of the Lender’s security interest or termination of the ground lease provided at the time of such foreclosure or termination Tenant is not in default (beyond the applicable
cure period) under this Lease. 
 15.2 Sale Of Landlord’s Interest. Upon sale, transfer or assignment of Landlord’s entire
interest in the Building and Property and the written assumption of this Lease in writing by such transferee, Landlord shall be relieved of its obligations hereunder with respect to liabilities accruing from and after the date of such sale, transfer
or assignment. 
 15.3 Estoppel Certificates. Tenant shall at any time and from time to time, within ten (10) days after written
request by Landlord, execute, acknowledge and deliver to Landlord a certificate in writing stating: (i) that this Lease is unmodified and in full force and effect, or if there have been any modifications, that this Lease is in full force and
effect as modified and stating the date and the nature of each modification; (ii) the date to which rental and all other sums payable hereunder have been paid; (iii) that Landlord is not in default in the performance of any of its
obligations under this Lease, that Tenant has given no notice of default to Landlord and 

  

 - 17 - 

 
that no event has occurred which, but for the expiration of the applicable time period, would constitute an event of default hereunder, or if Tenant alleges
that any such default, notice or event has occurred, specifying the same in reasonable detail; and (iv) such other matters as may reasonably be requested by Landlord or any institutional lender, mortgagee, trustee, beneficiary, ground lessor,
sale/leaseback lessor or prospective purchaser of the Property. Any such certificate provided under this Section 15.3 may be relied upon by any lender, mortgagee, trustee, beneficiary, assignee or successor in interest to Landlord, by any
prospective purchaser, by any purchaser on foreclosure or sale, by any grantee under a deed in lieu of foreclosure of any mortgage or deed of trust on the Property or Premises, or by any other third party. Failure to execute and return within the
required time any estoppel certificate requested hereunder shall be deemed to be an admission of the truth of the matters set forth in the form of certificate submitted to Tenant for execution. 
 15.4 Subordination to CC&R’s. This Lease, and any permitted sublease entered into by Tenant under the provisions of this Lease, shall be
subject and subordinate (a) to any declarations of covenants, conditions and restrictions affecting the Property from time to time, provided that the terms of such declarations are reasonable and do not discriminate against Tenant relative to
other similarly situated tenants occupying portions of the Property, and (b) to the Declaration of Covenants, Conditions and Restrictions dated June 20, 1979 and recorded on July 5, 1979 as Instrument No. 79-130777, Alameda
County Records, as amended from time to time (the “Master Declaration”), the provisions of which Master Declaration are an integral part of this Lease. Tenant agrees to execute, upon request by Landlord, any documents reasonably
required from time to time to evidence such subordination. 
  

	16.	SECURITY 

 16.1 Deposit. 
 (a) Concurrently with Tenant’s execution of this Lease, Tenant shall deposit with Landlord the sum of Two Hundred Fifty-Seven
Thousand Seven Hundred Fifty-One and 90/100 Dollars ($257,751.90), which sum (the “Security Deposit”) shall be held by Landlord as security for the faithful performance of all of the terms, covenants, and conditions of this Lease to
be kept and performed by Tenant during the term hereof. If Tenant defaults beyond applicable notice and cure periods with respect to any provision of this Lease, including, without limitation, the provisions relating to the payment of rental and
other sums due hereunder, Landlord shall have the right, but shall not be required, to use, apply or retain all or any part of the Security Deposit for the payment of rental or any other amount which Landlord may spend or become obligated to spend
by reason of Tenant’s default or to compensate Landlord for any other loss or damage which Landlord may suffer by reason of Tenant’s default. If any portion of the Security Deposit is so used or applied, Tenant shall, within ten
(10) days after written demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit to its original amount and Tenant’s failure to do so shall be a material breach of this Lease. Landlord shall not
be required to keep any deposit under this Section separate from Landlord’s general funds, and Tenant shall not be entitled to interest thereon. The Security Deposit, or any balance thereof not applied or retained under this Section 16.1,
shall be returned to Tenant or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder, at the expiration of the term of this Lease and after Tenant has vacated the Premises. In the event of termination of
Landlord’s interest in this Lease, Landlord shall transfer all deposits then held by Landlord under this Section to Landlord’s successor in interest, whereupon Tenant agrees to release Landlord from all liability for the return of such
deposit or the accounting thereof. 
 (b) Notwithstanding the foregoing, the Security Deposit shall be reduced by $42,958.65
on each of the second, third, fourth and fifth anniversaries of the Commencement Date. Following the reduction on the fifth anniversary of the Commencement Date and for the remainder of the term of this Lease, as it may be extended, the Security
Deposit shall be the greater of $85,917.30 or two months minimum rental for the last two months of the then current term. 
  

	17.	MISCELLANEOUS 

 17.1 Notices. All notices,
consents, waivers and other communications which this Lease requires or permits either party to give to the other shall be in writing and shall be deemed 

  

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given when delivered personally (including delivery by private courier or express delivery service) or four (4) days after deposit in the United States
mail, registered or certified mail, postage prepaid, addressed to the parties at their respective addresses as follows: 
  

			
	 To Tenant:
	  	(until Commencement Date)
		
		  	Acologix, Inc.
		  	6121 Hollis Street
		  	Emeryville, CA 94608
		  	Attn: Amy Pfeiffer
		
		  	(after Commencement Date)
		
		  	Acologix, Inc.
		  	3960 Point Eden Way
		  	Hayward, CA 94945
		  	Attn: Manager of Administration
		
	 To Landlord:
	  	Hayward Point Eden I Limited Partnership
		  	c/o Britannia Management Services
		  	1939 Harrison Street, Suite 715
		  	Park Plaza Building
		  	Oakland, CA 94612
		  	Attn: _____________________
		
	 with copy to:
	  	Folger Levin & Kahn LLP
		  	Embarcadero Center West
		  	275 Battery Street, 23rd Floor
		  	San Francisco, CA 94111
		  	Attn: Adam Sachs

 or to such other address as may be contained in a notice at least fifteen (15) days prior to the address
change from either party to the other given pursuant to this Section. Rental payments and other sums required by this Lease to be paid by Tenant shall be delivered to Landlord at Landlord’s address provided in this Section, or to such other
address as Landlord may from time to time specify in writing to Tenant, and shall be deemed to be paid only upon actual receipt. 
 17.2
Successors And Assigns. The obligations of this Lease shall run with the land, and this Lease shall be binding upon and inure to the benefit of the parties hereto and their respective successors and assigns, except that the original Landlord
named herein and each successive Landlord under this Lease shall be liable only for obligations accruing during the period of its ownership of the Property, said liability terminating upon termination of such ownership and passing to the successor
lessor and the written assignment of such successor lessor of Landlord’s obligations under this Lease. 
 17.3 No Waiver. The
failure of Landlord to seek redress for violation, or to insist upon the strict performance, of any covenant or condition of this Lease shall not be deemed a waiver of such violation, or prevent a subsequent act which would originally have
constituted a violation from having all the force and effect of an original violation. 
 17.4 Severability. If any provision of this
Lease or the application thereof is held to be invalid or unenforceable, the remainder of this Lease or the application of such provision to persons or circumstances other than those as to which it is invalid or unenforceable shall not be affected
thereby, and each of the provisions of this Lease shall be valid and enforceable, unless enforcement of this Lease as so invalidated would be unreasonable or grossly inequitable under all the circumstances or would materially frustrate the purposes
of this Lease. 
 17.5 Litigation Between Parties. In the event of any litigation or other dispute resolution proceedings between the
parties hereto arising out of or in connection with this Lease, the prevailing party shall be reimbursed for all reasonable costs, including, but not limited to, reasonable accountants’ fees and attorneys’ fees, incurred in connection with
such proceedings 

  

 - 19 - 

 
(including, but not limited to, any appellate proceedings relating thereto) or in connection with the enforcement of any judgment or award rendered in such
proceedings. “Prevailing party” within the meaning of this Section shall include, without limitation, a party who dismisses an action for recovery hereunder in exchange for payment of the sums allegedly due, performance of covenants
allegedly breached or consideration substantially equal to the relief sought in the action. 
 17.6 Surrender. A voluntary or other
surrender of this Lease by Tenant, or a mutual termination thereof between Landlord and Tenant, shall not result in a merger but shall, at the option of Landlord, operate either as an assignment to Landlord of any and all existing subleases and
subtenancies, or a termination of all or any existing subleases and subtenancies. This provision shall be contained in any and all assignments or subleases made pursuant to this Lease. 
 17.7 Interpretation. The provisions of this Lease shall be construed as a whole, according to their common meaning, and not strictly for or
against Landlord or Tenant. The captions preceding the text of each Section and subsection hereof are included only for convenience of reference and shall be disregarded in the construction or interpretation of this Lease. 
 17.8 Entire Agreement. This written Lease, together with the exhibits hereto, contains all the representations and the entire understanding
between the parties hereto with respect to the subject matter hereof. Any prior correspondence, memoranda or agreements are replaced in total by this Lease and the exhibits hereto. This Lease may be modified only by an agreement in writing signed by
each of the parties. 
 17.9 Governing Law. This Lease and all exhibits hereto shall be construed and interpreted in accordance with
and be governed by all the provisions of the laws of the State of California. 
 17.10 No Partnership. The relationship between
Landlord and Tenant is solely that of a lessor and lessee. Nothing contained in this Lease shall be construed as creating any type or manner of partnership, joint venture or joint enterprise with or between Landlord and Tenant. 
 17.11 Financial Information. From time to time Tenant shall promptly provide directly to prospective lenders and purchasers of the Property
designated by Landlord such financial information pertaining to the financial status of Tenant as Landlord may reasonably request; provided, Tenant shall be permitted to provide such financial information in a manner which Tenant deems
reasonably necessary to protect the confidentiality of such information. In addition, from time to time, Tenant shall provide Landlord with such financial information pertaining to the financial status of Tenant as Landlord may reasonably request.
Landlord agrees that all financial information supplied to Landlord by Tenant shall be treated as confidential material, and shall not be disseminated to any person or entity without Tenant’s prior written consent, except that Landlord shall be
entitled to provide such information, subject to reasonable precautions to protect the confidential nature thereof, (i) to Landlord’s partners and professional advisors, solely for use in connection with Landlord’s execution and
enforcement of this Lease, and (ii) to prospective lenders and/or purchasers of the Property, solely for use in connection with their bona fide consideration of a proposed financing or purchase of the Property, provided that such
prospective lenders and/or purchasers are not engaged in businesses directly competitive with the business then being conducted by Tenant. For purposes of this Section, without limiting the generality of the obligations provided herein, it shall be
deemed reasonable for Landlord to request copies of Tenant’s most recent audited annual financial statements, or, if audited statements have not been prepared, unaudited financial statements for Tenant’s most recent fiscal year,
accompanied by a certificate of Tenant’s chief financial officer that such financial statements fairly present Tenant’s financial condition as of the date(s) indicated. 
 Landlord and Tenant recognize the need of Tenant to maintain the confidentiality of information regarding its financial status and the
need of Landlord to be informed of, and to provide to its partners and to prospective lenders and purchasers of the Property financial information pertaining to, Tenant’s financial status. Landlord and Tenant agree to cooperate with each other
in achieving these needs within the context of the obligations set forth in this Section. 
  

 - 20 - 

 17.12 Costs. If Tenant requests the consent of Landlord under any provision of this Lease for any
act that Tenant proposes to do hereunder, including, without limitation, assignment or subletting of the Premises, Tenant shall, as a condition to doing any such act and the receipt of such consent, reimburse Landlord promptly for any and all
reasonable costs and expenses incurred by Landlord in connection therewith, including, without limitation, reasonable attorneys’ fees. 
 17.13 Time. Time is of the essence of this Lease, and of every term and condition hereof. 
 17.14 Rules And
Regulations. Tenant shall observe, comply with and obey, and shall cause its employees, agents and, to the best of Tenant’s ability, invitees to observe, comply with and obey such rules and regulations as Landlord may promulgate from time
to time for the safety, care, cleanliness, order and use of the Premises, the Building and the Property; provided, however, that Tenant shall not be required to comply with any new rule or regulation that unreasonably interferes with Tenant’s
use of the Premises or materially increases the obligations or decreases the rights of Tenant under this Lease. 
 17.15 Brokers.
Landlord agrees to pay a brokerage commission to Cornish & Carey Commercial in connection with the consummation of this Lease in accordance with a separate agreement. Landlord and Tenant each represents and warrants to the other that no
broker other than Cornish & Carey Commercial and CRESA Partners participated in the consummation of this Lease and each of Landlord and Tenant agrees to indemnify, defend and hold the other harmless against any liability, cost or expense,
including, without limitation, reasonable attorneys’ fees, arising out of any claims for brokerage commissions or other similar compensation in connection with any conversations, prior negotiations or other dealings by the indemnifying with any
other broker. 
 17.16 Memorandum Of Lease. At any time during the term of this Lease, either party, at its sole expense, shall be
entitled to record a memorandum of this Lease and, if either party so elects, both parties agree to cooperate in the preparation, execution, acknowledgement and recordation of such document in reasonable form. 
 17.17 Corporate Authority. Tenant warrants that the person signing this Lease on behalf of Tenant is fully authorized to do so and, by so doing,
to bind Tenant. 
 17.18 Execution and Delivery. Submission of this Lease for examination or signature by Tenant does not constitute
an agreement or reservation of or option for lease of the Premises. This instrument shall not be effective or binding upon either party, as a lease or otherwise, until executed and delivered by both Landlord and Tenant. This Lease may be executed in
one or more counterparts and by separate parties on separate counterparts, but each such counterpart shall constitute an original and all such counterparts together shall constitute one and the same instrument. 
 17.19 Parking. Tenant shall be entitled to use, at no additional cost to Tenant, fifty- seven (57) parking spaces on a non-reserved and
non-exclusive basis beginning on the Commencement Date and an additional twelve (12) parking spaces on a non-reserved non exclusive basis beginning on the Phase II Premises Commencement Date. Landlord shall not over-subscribe parking for the
Building or the Property. 
 17.20 Signage. Tenant may, at Tenant’s cost, install building signage comparable to other tenants of
the Property who have leased premises of approximately the same area as the Premises as more particularly described in Exhibit F hereto, provided that the design and placement have been approved by Landlord. 
 17.21 Approvals. Whenever this Lease requires an approval, consent, determination, selection or judgment by either Landlord or Tenant, unless
another standard is expressly set forth, such approval, consent, determination, selection or judgment and any conditions imposed thereby shall be reasonable and shall not be unreasonably withheld or delayed and, in exercising any right or remedy
hereunder, each party shall at all times act reasonably and in good faith. 
  

 - 21 - 

 IN WITNESS WHEREOF, the parties hereto have executed this Lease as of the day and year first set forth above. 

 

									
	“Landlord”	 		 	“Tenant”
			
	 Hayward Point Eden I Limited Partnership,
 a
Delaware limited partnership
	 		 	 Acologix, Inc., a
 Delaware
corporation

					
	By:	 	/s/ Randall W Rohner	 		 	By:	 	/s/ Illegible
		 	Randall W Rohner	 		 	Its:	 	President and CEO
		 	V. P.	 		 		 	
		 		 	By:	 	  
		 		 		 	Its:	 	  

  

 - 22 - 

 EXHIBITS 
  

			
	EXHIBIT A	  	Location of Premises
		
	EXHIBIT B	  	Real Property Description
		
	EXHIBIT C	  	Construction
		
	EXHIBIT D	  	Acknowledgement of Lease Commencement
		
	EXHIBIT E	  	Non-Disturbance and Attornment Agreement

  

 - 23 - 

 EXHIBIT A 
 (Page 1 of 2) 
 

 

 EXHIBIT A 
 (Page 2 of 2) 
 

 

 EXHIBIT B 
 REAL PROPERTY DESCRIPTION 
 Improved real property located in the City of Hayward, County of Alameda, State of
California, more particularly described as follows: 
 Lots 2, 3, 4, 5 and 7, Tract 4019, filed June 28, 1979, Map Book 100, Pages 97, 98 and 99,
Alameda County Records. 
 Subject to easements, restrictions and other matters of record affecting title. 
  

 - 25 - 

 EXHIBIT C 
 CONSTRUCTION 
 Landlord, at its sole cost and expense, shall undertake and diligently
complete, subject to delays for causes beyond its reasonable control, leasehold improvements in accordance with plans and specifications attached hereto as Exhibit C-1 (the “Tenant Improvements”). Such work shall be performed in a neat and
workmanlike manner and shall conform to all applicable governmental codes, laws and regulations in force at the time such work is completed. To the extent a demising wall separating the Phase I Premises and the Phase II Premises is not shown on the
plans and specifications, Landlord will construct such a wall as part of the Tenant Improvements delivered to Tenant on the Commencement Date. 
 Landlord may modify the plans and specifications for the Tenant Improvements, provided those modifications do not materially affect Tenant’s ability to conduct its primary business within the Premises or result in a decrease in the
quality or capacity of any of the improvements or contradict any express specifications. Tenant may request changes in the Tenant Improvement work. If Tenant requests any changes, Landlord will notify Tenant of the reasonably expected cost and any
reasonably expected delay associated with such changes and Landlord will not perform any such changes unless Tenant then requests Landlord to perform such changes. Tenant will be solely responsible for paying for any changes requested by Tenant, and
Landlord may also require Tenant to advance the expected cost of the changes before performing the work. 
  

 - 26 - 

 EXHIBIT C-1 
 FINISHES 
  

					
	

	  	TENANT IMPROVEMENTS FOR:	  	

	 CHAMORRO DESIGN GROUP
	  	PROPOSED INTERIOR FINISHES	  	
	 FILE 20402-03
	  	 06/08/04                07/01/04 REV 3
	  	

  

													
	 RM #
	  	ROOM	  	FLOOR	  	BASE	  	 WALLS
	  	 CEILING
	  	MISC
	1	  	RECEPTION	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	2	  	CONFERENCE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	3	  	FILES/DOC	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	4	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	5	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	6	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	7	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	8	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	9	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	10	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	11	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	12	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	13	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	14	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	15	  	ELECTRIC	  	VCT TILE	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	16	  	SERVER	  	VCT TILE	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	17	  	OPEN OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	18	  	BOARD ROOM	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	19	  	FILES	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	20	  	WOMEN	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	EGGSHELL ENAMEL ON GB	  	1,4,5
	21	  	MEN	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	EGGSHELL ENAMEL ON GB	  	1,4,5
	22	  	STORAGE	  	VCT TILE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	EGGSHELL ENAMEL ON GB	  	
	23	  	JANITOR	  	VCT TILE	  	4” VINYL TOPSET	  	SEMI GLOSS ENAMEL ON GB.	  	EGGSHELL ENAMEL ON GB	  	1
	24	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	25	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	26	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	27	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	28	  	CHEMISTRY	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	2,7
	29	  	BIOLOGY	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	2,6
	30	  	MICRO	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	
	31	  	DARK ROOM	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH VINYL WRAP TILE	  	2,7
	32	  	CAGE WASH	  	TROWELED EPOXY	  	ROLLED EPOXY	  	EPOXY PAINT ON GYP. BD.	  	EPOXY PAINT ON GYP. BD.	  	2,7

													
	 RM #
	  	ROOM	  	FLOOR	  	BASE	  	 WALLS
	  	 CEILING
	  	MISC
							
	 33
	  	SUPPLY	  	SHEET VINYL	  	SELF COVE	  	EPOXY PAINT ON GYP. BD.	  	T-BAR WITH FISSURED TILE	  	
	 34
	  	HOLDING	  	SHEET VINYL	  	SELF COVE	  	EPOXY PAINT ON GYP. BD.	  	T-BAR WITH FISSURED TILE	  	
	 35
	  	PROCEDURE	  	SHEET VINYL	  	SELF COVE	  	EPOXY PAINT ON GYP. BD.	  	T-BAR WITH FISSURED TILE	  	2,6
	 36
	  	ANTE	  	SHEET VINYL	  	SELF COVE	  	EPOXY PAINT ON GYP. BD.	  	T-BAR WITH FISSURED TILE	  	
	 37
	  	TISSUE CULTURE 1	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH VINYL WRAP TILE	  	2,6
	 38
	  	RADIOACTIVE	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	2,6
	 39
	  	COORIDOR 2	  	VCT TILE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	T-BAR WITH FISSURED TILE	  	
	 40
	  	COORIDOR 1	  	VCT TILE	  	4”VINYLTOPSET	  	EGGSHELL ENAMEL ON GB	  	T-BAR WITH FISSURED TILE	  	
	 41
	  	EQUIPMENT	  	VCT TILE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	T-BAR WITH FISSURED TILE	  	
	 42
	  	GLASS WASH	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	2,7
	 43
	  	TISSUE CULTURE 2	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH VINYL WRAP TILE	  	2,7
	 44
	  	BREAK ROOM	  	VCT TILE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	T-BAR WITH FISSURED TILE	  	3,4
	 45
	  	SHIP/REC	  	SEALED CONCETE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	EXPOSED FRAMING	  	
	 46
	  	HALL	  	VCT TILE	  	4” VINYL TOPSET	  	EGGSHELL ENAMEL ON GB	  	T-BAR WITH FISSURED TILE	  	
	 47
	  	SMALL LAB	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH FISSURED TILE	  	2,6
	 48
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 49
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 50
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 51
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 52
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 53
	  	OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 54
	  	TISSUE CULTURE 3	  	SHEET VINYL	  	SELF COVE	  	SEMI GLOSS ENAMEL ON GB.	  	T-BAR WITH VINYL WRAP TILE	  	2,7
	 55
	  	CONFERENCE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	
	 56
	  	OPEN OFFICE	  	CARPET	  	4” VINYL TOPSET	  	FLAT PAINT ON GYP.BD.	  	T-BAR WITH FISSURED TILE	  	

 MISCELLANEOUS 
  

	1	MARLITE WAINSCOT ON WET WALLS 

  

	2	METAL CASEWORK 

  

	3	PLASTIC LAMINATE CASEWORK 

  

	4	PLASTIC LAMINATE COUNTER-TOP 

  

	5	METAL TOILET PARTITIONS—OVERHEAD BRACED 

  

	6	EPOXY COUNTER-TOPS & SINK 

  

	7	S.S.SINK 

 EXHIBIT C-1 
 SPACE PLAN 
 

 

 EXHIBIT D 
 ACKNOWLEDGEMENT OF LEASE COMMENCEMENT 
 This Acknowledgement is executed as of
                    , 2004, by Hayward Point Eden I Limited Partnership, a Delaware limited partnership (“Landlord”), and Acologix,
Inc., a Delaware corporation (“Tenant”), pursuant to Section 2.5 of the Lease dated July             , 2004 between Landlord and Tenant (the “Lease”)
covering premises located at 3988 Trust Way, Hayward, CA 94945 (the “Premises”). 
 Landlord and Tenant hereby acknowledge and
agree as follows: 
 1. The Commencement Date under the Lease is
                    ,             . 
 2. The termination date under the Lease shall be
                    ,             , subject to any applicable provisions of
the Lease for extension or early termination thereof. 
 3. The agreed square footage of the Premises, as built, is
                     square feet. 
 4. Tenant accepts the Premises and acknowledges the satisfactory completion of all improvements therein (if any) required to be made by Landlord, subject only to any applicable “punch list” or similar
procedures specifically provided under the Lease. 
 EXECUTED as of the date first set forth above. 
  

											
	“Landlord”	 		 	“Tenant”
			
	 Hayward Point Eden I Limited Partnership, a
 Delaware limited partnership
	 		 	Acologix, Inc., a
Delaware corporation
					
	By:	 	  	 		 	By:	 	  
		 	  	 		 		 	
		 	  	 		 	Its:	 	  
						
		 	By:	 	  	 		 		 	
		 		 	  	 		 		 	
		 		 	  	 		 		 	

  

 -27- 

 EXHIBIT E 
 NON-DISTURBANCE AND ATTORNMENT AGREEMENT 
 RECORDING REQUESTED BY 
  

	
	
	   
	
	 WHEN RECORDED MAIL TO

 The Northwestern Mutual Life Ins. Co. 
 720 East Wisconsin Ave. - Rm N16WC 
 Milwaukee, WI 53202 
 Attn: 
 Loan No.         SPACE ABOVE THIS LINE FOR RECORDER’S USE 
 NON-DISTURBANCE AND ATTORNMENT AGREEMENT 
 THIS AGREEMENT is entered into as of
                    , 20    , between
                    , whose mailing address is
                    , (“Tenant”),
                    , whose mailing address is
                    , (“Borrower”), and THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY, a Wisconsin corporation
(“Lender”), whose address for notices is 720 East Wisconsin Avenue, Milwaukee, WI 53202, Attention: Real Estate Investment Department, Reference Loan No.
                    . 
 RECITALS 
 A. Tenant is the lessee or successor to the lessee, and Borrower is the lessor or successor to the lessor under a
certain lease dated                     , 20     (the “Lease”). 
 B. Lender has made, or will make, a mortgage loan to be secured by a mortgage, deed to secure a debt or deed of trust from Borrower for the benefit of
Lender (as it may be amended, restated or otherwise modified from time to time, the “Lien Instrument”) encumbering the fee title to and/or leasehold interest in the land described in Exhibit A attached hereto and the improvements thereon
(collectively, the “Property”), wherein the premises covered by the Lease (the “Demised Premises”) are located. 
 C.
Borrower and Lender have executed, or will execute, an Absolute Assignment of Leases and Rents (the “Absolute Assignment”), pursuant to which (i) the Lease is assigned to Lender and (ii) Lender grants a license back to Borrower
permitting Borrower to collect all rents, income and other sums payable under the Lease until the revocation by Lender of such license, at which time all rents, income and other sums payable under the Lease are to be paid to Lender. 
  

 1 

 D. Lender has required the execution of this Agreement by Borrower and Tenant as a condition to Lender
making the requested mortgage loan or consenting to the Lease. 
 E. Tenant acknowledges that, as its consideration for entering into this
Agreement, Tenant will benefit by entering into an agreement with Lender concerning Tenant’s relationship with any purchaser or transferee of the Property (including Lender) in the event of foreclosure of the Lien Instrument or a transfer of
the Property by deed in lieu of foreclosure (any such purchaser or transferee and each of their respective successors or assigns is hereinafter referred to as “Successor Landlord”). 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing, the mutual
covenants and agreements contained herein, and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Tenant, Borrower and Lender agree as follows: 
 1. Tenant and Borrower agree for the benefit of Lender that: 
  

	 	(a)	Tenant shall not pay, and Borrower shall not accept, any rent or additional rent more than one month in advance; 

  

	 	(b)	Except as specifically provided in the Lease, Tenant and Borrower will not enter into any agreement for the cancellation of the Lease or the surrender of the Demised Premises
without Lender’s prior written consent; 

  

	 	(c)	Tenant and Borrower will not enter into any agreement amending or modifying the Lease without Lender’s prior written consent, except for amendments or modifications
specifically contemplated in the Lease for confirming the lease commencement date, the rent commencement date, the term, the square footage leased, the renewal or extension of the Lease, or the leasing of additional space at the Property;

  

	 	(d)	Tenant will not terminate the Lease because of a default thereunder by Borrower unless Tenant shall have first given Lender written notice and a reasonable opportunity to cure such
default; and 

  

	 	(e)	 Tenant, upon receipt of notice from Lender that it has exercised its rights under the Absolute Assignment and revoked the license granted to Borrower to collect all
rents, income and other sums payable under the Lease, shall pay to Lender all rent and other payments then or thereafter due 

  

 2 

	 	 
under the Lease, and any such payments to Lender shall be credited against the rent or other obligations due under the Lease as if made to Borrower.

  

	 	(f)	Tenant will not conduct any dry cleaning operations on the Demised Premises using chlorinated solvents nor will Tenant use any chlorinated solvents in the operation of their
business on the Demised Premises. 

  

	 	(g)	Tenant shall pay any and all termination fees due and payable under the Lease directly to Lender to be held in an account satisfactory to Lender. 

 2. The Lease is hereby subordinated in all respects to the Lien Instrument and to all renewals, modifications and extensions thereof, subject to the
terms and conditions hereinafter set forth in this Agreement, but Tenant waives, to the fullest extent it may lawfully do so, the provisions of any statute or rule of law now or hereafter in effect that may give or purport to give it any right or
election to terminate or otherwise adversely affect the Lease or the obligations of Tenant thereunder by reason of any foreclosure proceeding. 
 3. Borrower, Tenant and Lender agree that, unless Lender shall otherwise consent in writing, the fee title to, or any leasehold interest in, the Property and the leasehold estate created by the Lease shall not merge but shall remain
separate and distinct, notwithstanding the union of said estates either in Borrower or Tenant or any third party by purchase, assignment or otherwise. 
 4. If the interests of Borrower in the Property are acquired by a Successor Landlord: 
  

	 	(a)	If Tenant shall not then be in default in the payment of rent or other sums due under the Lease or be otherwise in material default under the Lease, the Lease shall not terminate or
be terminated and the rights of Tenant thereunder shall continue in full force and effect except as provided in this Agreement; 

  

	 	(b)	Tenant agrees to attorn to Successor Landlord as its lessor; Tenant shall be bound under all of the terms, covenants and conditions of the Lease for the balance of the term thereof,
including any renewal options which are exercised in accordance with the terms of the Lease; 

  

	 	(c)	The interests so acquired shall not merge with any other interests of Successor Landlord in the Property if such merger would result in the termination of the Lease;

  

 3 

	 	(d)	If, notwithstanding any other provisions of this Agreement, the acquisition by Successor Landlord of the interests of Borrower in the Property results, in whole or part, in the
termination of the Lease, there shall be deemed to have been created a lease between Successor Landlord and Tenant on the same terms and conditions as the Lease, except as modified by this Agreement, for the remainder of the term of the Lease with
renewal options, if any; and 

  

	 	(e)	Successor Landlord shall be bound to Tenant under all of the terms, covenants and conditions of the Lease, and Tenant shall, from and after Successor Landlord’s acquisition of
the interests of Borrower in the real estate, have the same remedies against Successor Landlord for the breach of the Lease that Tenant would have had under the Lease against Borrower if the Successor Landlord had not succeeded to the interests of
Borrower; provided, however, that Successor Landlord shall not be: 

  

	 	(i)	Liable for the breach of any representations or warranties set forth in the Lease or for any act, omission or obligation of any landlord (including Borrower) or any other party
occurring or accruing prior to the date of Successor Landlord’s acquisition of the interests of Borrower in the Demised Premises, except for any repair and maintenance obligations of a continuing nature as of the date of such acquisition;

  

	 	(ii)	Subject to any offsets or defenses which Tenant might have against any landlord (including Borrower) prior to the date of Successor Landlord’s acquisition of the interests of
Borrower in the Demised Premises; 

  

	 	(iii)	Liable for the return of any security deposit under the Lease unless such security deposit shall have been actually deposited with Successor Landlord; 

  

	 	(iv)	Bound to Tenant subsequent to the date upon which Successor Landlord transfers its interest in the Demised Premises to any third party; 

  

	 	(v)	Liable to Tenant under any indemnification provisions set forth in the Lease; or 

  

 4 

	 	(vi)	Liable for any damages in excess of Successor Landlord’s equity in the Property. 

 The provisions of this paragraph shall be effective and self-operative immediately upon Successor Landlord succeeding to the interests of Borrower without the execution of any other instrument. 
 5. Tenant represents and warrants that Tenant, all persons and entities owning (directly or indirectly) an ownership interest in Tenant and all
guarantors of all or any portion of the Lease: (i) are not, and shall not become, a person or entity with whom Lender is restricted from doing business with under regulations of the Office of Foreign Asset Control (“OFAC”) of the
Department of the Treasury (including, but not limited to, those named on OFAC’s Specially Designated and Blocked Persons list) or under any statute, executive order (including, but not limited to, the September 24, 2001 Executive Order
Blocking Property and Prohibiting Transactions With Persons Who Commit, Threaten to Commit, or Support Terrorism), or other governmental action; (ii) are not knowingly engaged in, and shall not engage in, any dealings or transaction or be
otherwise associated with such persons or entities described in (i) above; and (iii) are not, and shall not become, a person or entity whose activities are regulated by the International Money Laundering Abatement and Financial
Anti-Terrorism Act of 2001 or the regulations or orders thereunder. 
 6. This Agreement may not be modified orally or in any other manner
except by an agreement in writing signed by the parties hereto or their respective successors in interest. In the event of any conflict between the terms of this Agreement and the terms of the Lease, the terms of this Agreement shall prevail. This
Agreement shall inure to the benefit of and be binding upon the parties hereto, their respective heirs, successors and assigns, and shall remain in full force and effect notwithstanding any renewal, extension, increase, or refinance of the
indebtedness secured by the Lien Instrument, without further confirmation. Upon recorded satisfaction of the Lien Instrument, this Agreement shall become null and void and be of no further effect. 
  

 5 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year first above
written. 
  

					
	TENANT:	 	________________________________________
			
		 	By:	 	  
			
		 	 Attest:
	 	  
		 		 	Secretary

  

					
	STATE OF	  	)	  	
		  	)	  	ss.
	COUNTY OF	  	)	  	

 On
                                        
                                        , before
me,
                                        
                        ,
                     personally appeared
                                        
        , personally known to me (or proved to me on the basis of satisfactory evidence) to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they
executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
  

			
	 WITNESS my hand and official seal.

		
	Signature	 	  
		
	  	 	  
	Name (typed or printed)

 (Signatures of Borrower and Lender continued on following pages) 
  

 6 

 (Signatures continued) 
  

					
	BORROWER:	 	________________________________________
			
		 	By:	 	  
			
		 	 Attest:
	 	  
		 		 	Secretary

					
	STATE OF	  	)	  	
		  	)	  	ss.
	COUNTY OF	  	)	  	

 On
                                        
                                        , before
me,
                                        
                        ,
                     personally appeared
                                        
        , personally known to me (or proved to me on the basis of satisfactory evidence) to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they
executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
  

			
	 WITNESS my hand and official seal.

		
	Signature	 	  
		
	  	 	  
	Name (typed or printed)

 (Signature of Lender continued on following pages) 
  

 7 

 (Signatures continued) 
  

							
	 LENDER:
	 	THE NORTHWESTERN MUTUAL LIFE INSURANCE COMPANY, a Wisconsin corporation
			
		 	 By:
	 	Northwestern Investment Management Company, LLC, a Delaware limited liability company, its wholly-owned affiliate and authorized representative
				
		 		 	 By:
	 	  
		 		 		 	                 , Managing Director

				
		 		 	 Attest:
	 	  
		 		 		 	                 , Assistant Secretary

  

					
	STATE OF	  	)	  	
		  	)	  	ss.
	COUNTY OF	  	)	  	

 On
                                        
                                        , before
me,
                                        
                        ,
                     personally appeared
                                        
        , personally known to me (or proved to me on the basis of satisfactory evidence) to be the person(s) whose name(s) is/are subscribed to the within instrument and acknowledged to me that he/she/they
executed the same in his/her/their authorized capacity(ies), and that by his/her/their signature(s) on the instrument the person(s), or the entity upon behalf of which the person(s) acted, executed the instrument. 
  

			
	 WITNESS my hand and official seal.

		
	Signature	 	  
		
	  	 	  
	Name (typed or printed)

 This instrument was prepared by Frederick W. Bessette, Attorney, for The Northwestern Mutual Life Insurance
Company, 720 East Wisconsin Avenue, Milwaukee, WI 53202. 
  

 8 

 TABLE OF CONTENTS 
  

							
	 	  	 	  	 	  	Page
	1.	  	PREMISES	  	1
				
		  	1.1	  	 Premises
	  	1
				
		  	1.2	  	 Landlord’s Reserved Rights
	  	1
			
	2.	  	TERM	  	1
				
		  	2.1	  	 Term
	  	1
				
		  	2.2	  	 Early Possession
	  	2
				
		  	2.3	  	 Delay In Possession
	  	2
				
		  	2.4	  	 Construction
	  	2
				
		  	2.5	  	 Acknowledgement Of Lease Commencement
	  	3
				
		  	2.6	  	 Holding Over
	  	3
				
		  	2.7	  	 Option To Extend Term
	  	3
			
	3	  	RENTAL	  	4
				
		  	3.1	  	 Minimum Rental
	  	4
				
		  	3.2	  	 Late Charge
	  	5
			
	4.	  	TAXES	  	5
				
		  	4.1	  	 Personal Property
	  	5
				
		  	4.2	  	 Real Property
	  	5
			
	5.	  	OPERATING EXPENSES	  	6
				
		  	5.1	  	 Payment Of Operating Expenses
	  	6
				
		  	5 2	  	 Definition Of Operating Expenses
	  	6
				
		  	5.3	  	 Determination Of Operating Expenses
	  	7
				
		  	5.4	  	 Final Accounting For Lease Year
	  	7
				
		  	5 5	  	 Proration
	  	7
			
	6.	  	UTILITIES	  	8
				
		  	6.1	  	 Payment
	  	8
				
		  	6.2	  	 Interruption
	  	8
			
	7	  	ALTERATIONS	  	8
				
		  	7.1	  	 Right To Make Alterations
	  	8
				
		  	7.2	  	 Title To Alterations
	  	8
				
		  	7.3	  	 Tenant Fixtures
	  	8
				
		  	7 4	  	 No Liens
	  	8
			
	8.	  	MAINTENANCE AND REPAIRS	  	8
				
		  	8.1	  	 Landlord’s Work
	  	8
				
		  	8.2	  	 Tenant’s Obligation For Maintenance
	  	9
			
	9.	  	USE OF PREMISES	  	9
				
		  	9.1	  	 Permitted Use
	  	9
				
		  	9.2	  	 [Reserved.]
	  	9
				
		  	9.3	  	 No Nuisance
	  	9
				
		  	9.4	  	 Compliance With Laws
	  	10
				
		  	9.5	  	 Liquidation Sales
	  	10
				
		  	9.6	  	 Environmental Matters
	  	10

  

 -i- 

 TABLE OF CONTENTS 
 (continued) 
  

							
	 	  	 	  	 	  	Page
	 10.
	  	 INSURANCE AND INDEMNITY
	  	11
				
		  	10.1	  	 Liability Insurance
	  	11
				
		  	10.2	  	 Quality Of Policies And Certificates
	  	11
				
		  	10.3	  	 Workers’ Compensation
	  	11
				
		  	10.4	  	 Waiver Of Subrogation
	  	12
				
		  	10.5	  	 Increase In Premiums
	  	12
				
		  	10.6	  	 Indemnification
	  	12
				
		  	10.7	  	 Blanket Policy
	  	12
			
	 11.
	  	 SUBLEASE AND ASSIGNMENT
	  	12
				
		  	11.1	  	 Assignment And Sublease Of Premises
	  	12
				
		  	11.2	  	 Rights Of Landlord
	  	13
			
	 12.
	  	 RIGHT OF ENTRY AND QUIET ENJOYMENT
	  	14
				
		  	12.1	  	 Right Of Entry
	  	14
				
		  	12.2	  	 Quiet Enjoyment
	  	14
			
	 13.
	  	 CASUALTY AND TAKING
	  	14
				
		  	13.1	  	 Termination Or Reconstruction
	  	14
				
		  	13.2	  	 Tenant’s Rights
	  	14
				
		  	13.3	  	 Lease To Remain In Effect
	  	14
				
		  	13.4	  	 Reservation Of Compensation
	  	15
				
		  	13.5	  	 Restoration Of Fixtures
	  	15
			
	 14.
	  	 DEFAULT
	  	15
				
		  	14.1	  	 Events Of Default
	  	15
				
		  	14.2	  	 Remedies Upon Tenant’s Default
	  	16
				
		  	14.3	  	 Remedies Cumulative
	  	17
			
	 15.
	  	 SUBORDINATION ATTORNMENT AND SALE
	  	17
				
		  	15.1	  	 Subordination To Mortgage
	  	17
				
		  	15.2	  	 Sale Of Landlord’s Interest
	  	17
				
		  	15.3	  	 Estoppel Certificates
	  	17
				
		  	15.4	  	 Subordination to CC&R’s
	  	18
			
	 16.
	  	 SECURITY
	  	18
				
		  	16.1	  	 Deposit
	  	18
			
	 17.
	  	 MISCELLANEOUS
	  	18
				
		  	17.1	  	 Notices
	  	18
				
		  	17.2	  	 Successors And Assigns
	  	19
				
		  	17.3	  	 No Waiver
	  	19
				
		  	17.4	  	 Severability
	  	19
				
		  	17.5	  	 Litigation Between Parties
	  	19
				
		  	17.6	  	 Surrender
	  	20
				
		  	17.7	  	 Interpretation
	  	20
				
		  	17.8	  	 Entire Agreement
	  	20
				
		  	17.9	  	 Governing Law
	  	20

  

 -ii- 

 TABLE OF CONTENTS 
 (continued) 
  

					
	 	 	 	  	Page
	 17.10
	 	 No Partnership
	  	20
			
	 17.11
	 	 Financial Information
	  	20
			
	 17.12
	 	 Costs
	  	21
			
	 17.13
	 	 Time
	  	21
			
	 17.14
	 	 Rules And Regulations
	  	21
			
	 17.15
	 	 Brokers
	  	21
			
	 17.16
	 	 Memorandum Of Lease
	  	21
			
	 17.17
	 	 Corporate Authority
	  	21
			
	 17.18
	 	 Execution and Delivery
	  	21
			
	 17.19
	 	 Parking
	  	21
			
	 17.20
	 	 Signage
	  	21
			
	 17.21
	 	 Approvals
	  	21

  

 -iii-Collaboration and License Agreement dated April 14, 1999

 EXHIBIT 10.7 
 COLLABORATION AND LICENCE AGREEMENT 
 THIS AGREEMENT is made this 14th day of April 1999 by and between 

UNIVERSITY COLLEGE LONDON, incorporated in the United Kingdom by Royal Charter, acting through its Royal Free and University College Medical School and Freemedic plc,
whose address is Rowland Hill Street, London NW3 2PF, United Kingdom (together, “RFUCMS”) 
 and 
 Big Bear Bio Inc., of P.O. Box 25268, San Mateo, CA 94402, USA (“BBB”). 
 WHEREAS 
  

	A.	RFUCMS, by virtue of discoveries made by or under the direction of its employee, Dr Peter S N Rowe, is owner of certain intellectual property rights relating to the regulation of
phosphate metabolism (the “Technology”); 

  

	B.	BBB is a company whose business is the research, development and commercialisation of products in the area of endocrinology and mineral metabolism; 

  

	C.	BBB wishes to provide funding to support further research at RFUCMS into the Technology, and to obtain a licence to develop and commercialise products arising therefrom;

  

	D.	RFUCMS is willing to grant a licence to BBB subject to the terms and conditions hereof. 

 NOW THEREFORE the parties are agreed as follows: 
  

	1.	Definitions 

  

			
	Funded Research	  	A programme of research, a description and the objectives of which are set out in Appendix I hereto, to be carried out at RFUCMS under the direction of Dr Rowe (or an acceptable substitute as
provided for herein) to investigate and increase knowledge of a putative novel polypeptide (“Phosphatonin”), fragments and/or derivatives thereof, receptors therefor and substances acting on or bound by such receptors, involved in the
regulation of phosphate metabolism.
		
	Licensed Patent	  	Any patent issued upon or deriving priority from the Patent Applications, including any foreign patent corresponding thereto, and/or any divisions, continuations or reissues
thereof.
		
	 Net Sales Value
 (NSV)
	  	The amount invoiced by BBB, its distributor(s) or sub-licensee(s) in respect of sales of Product(s) to any third party, excluding any tax on such invoiced amount and less any discounts credits
or allowance for price reductions in accord with normal business practice and refunds or allowance for returns. The transfer of goods between BBB and its distributor(s) and sub-licensees shall not counted as sales for the purpose of calculating Net
Sales Value.
		
	Patent Applications	  	Patent Application GB 9810681.8 dated 18 May 1998 and Patent Application GB 9819387.3 dated 4 September 1998, filed in the name of University College London, together with any future
patent applications deriving their subject matter from the Funded Research and filed in the name of RFUCMS or its nominee, and RFUCMS’s title in any “Joint Patent” as contemplated by Article 5.3.
		
	Product	  	Any product deriving from the Research, whether or not incorporated into a pharmaceutical formulation or other vehicle, and which is sold or offered for sale as an agent for the therapy,
diagnosis or prevention of disease, or as a laboratory reagent
		
		  	

  

					
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		  	or investigational tool, or any other use for commercial purposes.
		
	Research	  	The Funded Research together with research and development work carried out by or on behalf of BBB as contemplated by Article 2.5, on materials and/or discoveries and information arising from
the Funded Research or otherwise furnished to BBB by RFUCMS pursuant to this Agreement.

  

	2.	Collaborative Research and Funding 

  

	2.1	BBB will pay to RFUCMS [***] in support of the Funded Research, such payment shall be inclusive of RFUCMS normal costs for overheads associated with the Funded Research, but
exclusive of Value Added Tax (currently 0% for non-EC countries). Any reasonable expense incurred by RFUCMS personnel directly in connection with travel requested by BBB (e.g. to attend review meetings) shall be reimbursed by BBB as an additional
expense promptly upon presentation of RFUCMS’s invoice. 

  

	2.2	Payment will be made in [***] by wire transfer of immediately available funds to General Call Account Number [***], quoting reference “BBB”, in four equal instalments
6-monthly in advance, the first such instalment falling due immediately upon execution of this Agreement (the “Effective Date”). 

  

	2.3	The Funded Research will be conducted in the Department of Biochemistry and Molecular Biology of RFUCMS under the direction of Dr Rowe, and RFUCMS shall ensure that the personnel
equipment and facilities as set out in the costing attached hereto as Appendix II are made available to conduct the Funded Research. It is envisaged that the initial period of the Funded Research will be two years, subject to extension pursuant to
2.7 below. 

  

	2.4	In the event that Dr Rowe ceases to be available, and RFUCMS is unable, after all reasonable effort, to appoint a suitably qualified and experienced substitute acceptable to BBB
within one month from the date that Dr. Rowe ceases to be available, BBB shall have the right to terminate the payment of research funding, and any unused portion of funds already paid (excluding any irrevocable future commitment made by RFUCMS
in connection with the Funded Research) shall be refunded to BBB within one (1) month of BBB’s decision of termination. RFUCMS will make all reasonable endeavour to ensure that such commitments are kept to a minimum, and in any case no
commitment for a period exceeding 3 (three) months shall be deemed to be irrevocable. Termination in such circumstance shall not act to terminate the licence granted to BBB hereunder. The obligation of RFUCMS to make any refund pursuant to this
Article 2.4 and the right of BBB to reduce royalties pursuant to Article 4.5 below shall be null and void in the event that Dr Rowe ceases to be available as a consequence of any offer made either directly by BBB, or by any third party with the
inducement of BBB. 

  

	2.5	On receipt of the first instalment from BBB, RFUCMS will provide to BBB reasonable samples of materials and all information not previously made available to BBB, arising from Dr
Rowe’s studies on phosphate metabolism. BBB shall be entitled to use such materials and information, together with related materials and information furnished to BBB by RFUCMS in anticipation of this Agreement, to pursue independent research.

  

	2.6	RFUCMS will furnish to BBB quarterly reports of progress of the Funded Research. Any exceptional or unexpected finding from the Funded Research will be notified to BBB without undue
delay. BBB will furnish to RFUCMS the reports of its progress of Research at least [***], and its plans and timetables for the commercial development of any Products or Product candidates at least [***]. Any exceptional or unexpected progress, or
any material deviation from such plans or timetables by BBB will be notified to RFUCMS without undue delay. 

  

	2.7	The parties shall meet not later than three months before the second anniversary of the Effective Date to review progress of the Research and to agree terms for any extension to the
Funded Research. Such extension shall be funded by BBB 

  

	 	i)	from any funding paid pursuant to 2.1 above and remaining unspent 

  

	 	ii)	from additional funding at a rate to be agreed in writing between the parties 

  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission. 

  

	3.	Licence 

  

	3.1	In consideration of the funding pursuant to Article 2.1 above, RFUCMS will grant to BBB a world-wide exclusive licence to use the Licensed Patents and Patent Applications, materials
information and know-how arising from the Funded Research (whether or not protected by patent or capable of such protection) to carry out research on, develop, make, have made, sell, have sold or import one or more Products as herein defined, and to
practice any process, method or procedure and otherwise exploit the Products and Licensed Patents and Patent Applications. 

  

	3.2	RFUCMS retains the right, without obligation to BBB, to use the materials, information and know-how licensed hereunder to BBB for non-commercial research purposes.

  

	3.3	BBB shall have the right to appoint one or more sub-licensees upon terms to be negotiated by BBB. Any such sub-licence shall be co-terminous with the term of this Agreement, and
shall contain the provision that, in the event that this Agreement is terminated by RFUCMS pursuant to Article 7.2 below RFUCMS shall have the option of converting such sub-licence into a direct licence between RFUCMS and the sub-licensee. Any
sub-licensee appointed by BBB shall not have the right to appoint licensees. 

 BBB shall inform RFUCMS of the execution of any
sub-licence agreement within [***] of its execution. BBB shall provide RFUCMS with sufficient detail of the sub-licence and the profile of the sub-licensee to enable RFUCMS to determine its rights thereunder. 
  

	3.5	The licence granted by this Agreement is conditional upon diligent and effective exploitation of the rights granted to BBB, in a manner likely to satisfy the demand in the
commercial market for Product. BBB commits to undertake all commercially reasonable steps to bring one or more Product(s) to the market within a reasonable time frame, as set out in BBB’s business plans provided to RFUCMS pursuant to Article
2.6 above. 

 If in the periodic review of BBB’s progress reports it becomes apparent to RFUCMS that, extenuating
circumstances excepted, there has been a lack of reasonable diligence by BBB, RFUCMS shall have the right to request in writing BBB to explain its reasons for deviation from such plans. In the absence of an acceptable explanation within [***] of
such request, RFUCMS may at its sole discretion terminate the licence for one or more countries or convert it to a non-exclusive licence. 
  

	4.	Fees and Royalties 

  

	4.1	BBB shall pay RFUCMS milestone fees as follows: 

  

	 	i)	On entry into [***] of a Product for the treatment or prevention of disease, [***]; 

  

	 	ii)	On [***] for the treatment or prevention of any disease state [***]; 

  

	 	iii)	On [***] of a Product for the treatment or prevention of [***]; 

  

	 	iv)	On first commercial launch of the first Product for [***] that is formally registered under the laws and regulations of the government of any nation or area, [***].

  

	4.2	BBB shall pay to RFUCMS a percentage of lump-sum payments received by BBB as sub-licence fees as follows: 

  

	 	i)	For sub-licensees appointed [***] percent; 

  

	 	ii)	For sub-licensees appointed [***] percent. 

  

	4.3	BBB shall pay to RFUCMS royalties as a percentage of Net Sales Value of sales of Product by BBB, its distributors or sub-licensees as follows: 

  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission. 

  

	 	i)	In each territory where one or more Licensed Patents are in force, [***] of NSV for sales of therapeutic Products, [***] of NSV for sales of non-therapeutic Products, such royalties
to be payable while at least one Licensed Patent remains in force. 

  

	 	ii)	In each territory where no Licensed Patent is in force, [***] of NSV for sales of therapeutic Products, and [***] of NSV for sales of non-therapeutic Products, such royalties to be
payable for [***] from launch in the territory of the Product to which they relate. 

  

	4.4	Any lump-sum payment falling due hereunder shall be paid to RFUCMS not later than [***] from the date of the relevant milestone event or receipt by BBB of sub-licence fees as the
case may be. Royalty payments shall be paid quarterly in arrears and shall become due and payable not later than [***] after the end of the calendar quarter to which they relate. 

  

	4.5	[***] 

  

	4.6	[***] 

  

	4.7	For the avoidance of doubt, the parties are agreed that any reduction that BBB may be entitled to make shall not apply to any payment due to RFUCMS under Articles 4.1 and 4.2 above.

  

	5	Patents and Intellectual Property Rights 

  

	5.1	Ownership of the Licensed Patents shall remain at all times with RFUCMS, provided, however, that the Joint Patents defined in 5.3 below shall remain at all time co-owned by
RFUCMS and BBB. 

  

	5.2	BBB shall be entitled at its own cost and expense (subject to the provisions of 4.6 above) to determine patent strategy and prosecution of the Licensed Patents and the Patent
Applications using any representatives and/or patent counsels selected at the sole discretion of BBB. RFUCMS will at the request of BBB and at the expense of BBB execute all documents and do all things necessary for BBB to exercise such entitlement.
BBB shall keep RFUCMS fully informed of its activities in relation to the Licensed Patents and the Patent Applications. 

  

	5.3	Any patent application and patents issuing thereon claiming an invention arising from the Research in which any officer or employee of BBB has made an inventive contribution shall
be owned jointly by RFUCMS and BBB (“Joint Patent”). Prosecution of Joint Patents shall be at BBB’s own cost and expense. 

  

	5.4	Any such Joint Patent shall be regarded as a Licensed Patent for the purposes of calculating payment due to RFUCMS under Articles 4.1, 4.2 and 4.3 above but shall not be regarded as
a Licensed Patent for the purposes of Article 4.6. 

  

	5.5	RFUCMS shall give notice of any publication (including oral presentation) relating to the Funded Research, and shall provide to BBB a copy of the text of such publication not later
than [***] prior to the intended date of publication. BBB shall endeavour within [***] (and in no event more than [***]) of receipt to take what action it deems necessary for the protection of any invention disclosed by the intended publication, and
shall inform RFUCMS accordingly. 

  

	5.6	[***] In the event that [***] decides not to file for such patent protection, [***] shall inform [***] of its intention not later than [***] from such notification. [***] shall
thereafter be free at its sole discretion and expense to seek patent protection in its own name for such invention. The said invention shall fall outside the scope of the licence granted to BBB hereunder and RFUCMS shall be free to seek third party
licensees therefor. However, BBB shall have right of first refusal on [***] notice to take a separate licence to such invention on terms no less favourable than those negotiated with a third party. 

  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission. 

  

	5.7	In the event the [***] elects not to proceed with the prosecution of, or to renew the territorial filing of any Licensed Patent or Patent Application, [***] shall inform [***] of
its intention not less than [***] prior to any deadline. RFUCMS shall thereafter be free at its sole discretion and expense to pursue such prosecution or renewal. The said patents, applications or territories as the case may be shall fall outside
the scope of the license granted to BBB hereunder and RFUCMS shall be free to seek third party licensees therefor. However, BBB shall have right of first refusal on [***] notice to take a separate licence to such invention on terms no less
favourable than those negotiated with a third party. 

  

	5.8	In respect to serendipitous inventions arising from the Funded Research but having application outside the scope of the Research, BBB shall have right of first refusal, for [***]
from notification by RFUCMS of such invention, to take an exclusive licence to the invention on terms to be negotiated in good faith between the parties. BBB shall in any event have a royalty-free non-exclusive licence hereunder to use any such
invention to the extent that such use is essential to the development of one or more Products. 

 For the avoidance of doubt,
the parties agree that, for the purposes of this Agreement “serendipitous invention” shall mean a discovery, invention or technical improvement (whether or not capable of protection by patent, copyright or the like) which has general
utility not confined to the subject matter of the Funded Research (by way of illustration, a novel method of sequencing proteins). An unexpected finding relating only to the subject matter of the Research and arising therefrom, including (but not by
way of limitation) any unexpectedly obtained or cloned molecule, fragments and/or derivatives thereof, receptors therefor and substances acting on or bound by such receptors, and any unexpected utility therefor shall not be deemed to be a
serendipitous invention. 
  

	5.9	Each party shall notify the other party hereto promptly in the event that (a) it reasonably believes that any Licensed Patent is being infringed by a third party or (b) a
declaratory judgement action is brought or threatened against it with respect to any Licensed Patent. In such event BBB shall have the right (but not the obligation) to act as principal in taking action at its own expense (“Enforcement
Action”) in the enforcement of any Licensed Patent or in the defence of any declaratory judgement action against either of the parties hereto. 

  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission. 

  

	5.10	If BBB has not, within [***] of the notice contemplated by Article 5.9 above taken all reasonable steps to initiate appropriate Enforcement Action, or if having initiated such
action BBB thereafter abandons or fails diligently to pursue such Enforcement Action, RFUCMS shall have the right at its sole discretion and expense to take or to continue such action as the case may be and shall thereafter be principal in the said
action. In such event, BBB shall be entitled at its own expense to participate in such Enforcement Action with counsel of its choice. 

  

	5.11	The party acting as principal in any Enforcement Action shall keep the other party fully informed as to the progress of such action. The party not acting as principal shall, at the
reasonable request of the other party co-operate with that party, including without limitation by joining as party plaintiff, executing documents, and making available relevant personnel, records, papers, information, samples, specimens and other
similar materials in that party’s control. 

  

	5.12	The party acting as principal in any Enforcement Action in accordance with Articles 5.9 or 5.10 above shall bear the expenses of such action [***], provided however that, to the
extent that such damages are attributed to a Licensed Patent, shall first be applied to reimburse the expenses of the party acting as principal in such Enforcement Action, and secondly to reimburse the expenses (if any) of the other party incurred
in connection with such action, including without limitation reasonable attorney’s fees and court costs. Any remainder [***], with the following provisos: 

  

	 	(i)	BBB shall not be entitled to recover any expenses incurred in connection with such action prior to the abandonment or failure of diligence contemplated by Article 5.10, and

  

	 	(ii)	Any exemplary damages awarded to BBB in compensation for loss of sales shall be deemed to be Net Sales for the calculation of royalties due to RFUCMS pursuant to Article 4.3.

  

	6.	Statements and Accounts 

  

	6.1	BBB shall prepare and provide royalty statements to RFUCMS throughout the term of the Agreement and any extension thereof covering the periods ending [***] respectively, within
[***] from the end of the quarter to which they relate, providing such information as is reasonably required by RFUCMS to permit an accurate determination of the amount payable by BBB to RFUCMS in accordance with Section 4 of this Agreement.

  

	6.2	The royalty statements delivered by BBB to RFUCMS shall be accompanied by payment of the royalties due for the period ending [***] of each year during the term of this Agreement and
any extension thereof. Payments shall be made by a bank wire transfer of immediately available funds to an account designated by RFUCMS from time to time. Net Sales not invoiced in [***] shall be converted prior to royalty calculation using the rate
of exchange quoted in Wall Street Journal on the day such royalty payment is due to be made. 

  

	6.3	Where required by law, BBB shall withhold taxes required to be paid by any taxing authority on account of any payment to RFUCMS hereunder, and BBB shall obtain and furnish to RFUCMS
satisfactory evidence of such withholding and payment in order for RFUCMS to obtain a tax credit or other relief as may be available under applicable law. 

  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission. 

  

	6.4	BBB shall keep full, accurate and complete records and books of account relating to the Net Sales Value of Product sold by BBB, its distributors and sub-licensees, and all royalties
and similar fees received by BBB. BBB shall make such records available to RFUCMS during normal business hours, upon reasonable prior notice and permit RFUCMS and its authorised representative to inspect the records, and to take extracts from, and
make copies of, the records. BBB shall afford all facilities and collaboration to RFUCMS and its authorised representatives for such inspections and furnish representatives with the information necessary to understanding the records; and keep all
the records intact for a period of not less than [***]. 

  

	6.5	RFUCMS may from time to time, upon reasonable prior notice to BBB have the records and books of account kept in accordance with Article 6.4 audited or examined by a duly authorised,
independent accountant to ascertain the accuracy of the payments made by BBB to RFUCMS. The auditor shall report on the following: the amount payable and whether any underpayment or overpayment has been made. Should any audit of the Records of BBB
reveal an underpayment by BBB to RFUCMS, BBB shall immediately remit payment to RFUCMS in the amount of such underpayment plus interest calculated at the rate of [***] compounded monthly, which is an annual percentage of approximately [***] (or at
any such other rate as is from time to time established by RFUCMS and communicated in writing to BBB calculated from the date such payment was actually due until the date when such payment is actually made). Further, in the event that such
underpayment reflects a discrepancy of [***] from that which BBB ought to have paid, BBB shall reimburse RFUCMS for the costs and expenses of such audit including, but not limited to, reasonable lawyers’ fees incurred in connection therewith.
Should such an audit reveal an overpayment by BBB to RFUCMS, the overpayment shall be credited against Royalties payable in the future, unless the Agreement has been terminated before the overpayment becomes known, in which case the overpayment
shall be refunded to BBB. 

  

	7.	Term and Termination 

  

	7.1	This Agreement shall take effect from the Effective Date and shall endure for the lifetime of the last to expire of the Licensed Patents. 

  

	7.2	Without prejudice to the rights of either party, either party may terminate this Agreement forthwith by the service of notice in writing in the event that the other party is in
breach of this Agreement and in the case of a breach capable of remedy has within [***] of written notice of such breach failed to remedy the same. 

  

	7.3	Termination of this Agreement for whatever reason shall not terminate any rights accruing to either party prior to such termination, and shall not excuse BBB from making any payment
that may be due hereunder. 

  

	8.	Liability and Indemnities 

  

	8.1	The parties acknowledge the experimental nature of the research proposed hereunder and BBB acknowledges that no representation or warranty express or implied is given by RFUCMS as
to: 

  

	 	i)	the outcome of any programme of research or development whether undertaken individually or jointly; 

  

	 	ii)	the issuance and/or validity of any patent(s) deriving from the Patent Applications; 

  

	 	iii)	the fitness for any purpose of any material, information or know-how supplied to BBB hereunder. 

  

					
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the Commission. 

  

	8.2	BBB shall indemnify and hold harmless RFUCMS, its officers servants and agents against all liabilities, claims, proceedings, penalties, fines or other sanctions costs and expenses
however incurred which may be imposed or asserted against RFUCMS, BBB or any third party in any way related to or arising directly or indirectly in connection with any act or omission (other than the wilful misconduct of RFUCMS ) in relation to the
operation or use of any development, material, invention or information supplied by RFUCMS pursuant to this Agreement or the manufacture, control, possession, ownership, use, sale or other disposition by BBB or any third party of any Product
deriving therefrom. 

  

	8.3	RFUCMS shall indemnify and hold harmless BBB, its officers, servants ,and agents against all liabilities, claims, proceedings, penalties, fines or other sanction costs and expenses
however incurred which may be imposed or asserted against RFUCMS, BBB, or any third party in any way related to or arising directly or indirectly in connection with any act or omission (other than the wilful misconduct of BBB) in relation to the
operation of the Funded Research or use of any material supplied by BBB for the purpose of this Funded Research. 

  

	9.	Confidentiality 

  

	9.1	Information (including materials, scientific, technical or business information) furnished hereunder by one party to the other and marked as the confidential property of the
disclosing party, or if disclosed orally, is confirmed in writing within thirty (30) days of such disclosure (“Information”) shall be held in confidence by the receiving party in conditions no less secure than those for the
confidential property of that party, and access thereto shall be limited to those officers, servants and advisors of the receiving party who have reasonable need to know for the purposes of this Agreement. The receiving party shall ensure that all
such persons are made aware of the confidential nature of the Information, and shall undertake to be bound by conditions of confidentiality no less stringent than those contained herein. 

  

	9.2	The conditions of confidentiality shall not apply to any of the Information that a receiving party can demonstrate: 

  

	 	i)	Was in the public domain at the time of disclosure, or has subsequently become part of the public domain other than by the negligent act or omission of the receiving party; or

  

	 	ii)	Was lawfully in the possession of the receiving party (as evidenced by written record) at the time of disclosure; or 

  

	 	iii)	Was independently developed by the receiving party without reference to or reliance upon the Information; or 

  

	 	iv)	The receiving party is required to disclose by law, provided that such party takes all reasonable and lawful action to avoid or minimise such disclosure. 

 

	9.3	The obligations of non-disclosure embodied herein shall survive termination of this Agreement by a period of ten (10) years. 

  

	9.4	The details of this Agreement shall be Information for the purposes of this Agreement, and neither party shall publish or make reference to the same without the written agreement of
the other party. 

  

	9.5	Neither party shall use the name of the other party in any publicity, promotion or other written oral or electronic communication to third parties without the express written
permission of the other party. 

  

	9.6	During the term of this agreement, RFUCMS shall not deliver any experimental or commercial materials, information and know-how to make or use such materials under this licence to
any third party without prior written consent by BBB. 

  

					
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	10.	General 

  

	10.1	This Agreement shall not create any partnership or a relationship of principal and agent of the like between the parties. 

  

	10.2	The headings in this Agreement are for convenience only and shall not affect its interpretation or construction. 

  

	10.3	In the event that any provision of this Agreement is declared by any judicial or other competent authority to be void, illegal or otherwise unenforceable, the parties shall amend
that provision in such reasonable manner that achieves the intent of the parties without illegality, or if the parties are unable to agree on such amendment the relevant part of the provision shall be severed from this Agreement and the remaining
provisions shall remain. 

  

	10.4	Neither party shall be liable for any failure to fulfil any term or condition of this Agreement if fulfilment has been delayed, hindered or prevented by any event of force majeur
including, but not limited to, acts of God, any strike, lock out or other industrial dispute, acts of the elements or any occurrences beyond the control of the affected party, provided that that party promptly notifies the other of the nature and
likely duration of such delay, and when such force majeur ceases to apply. 

  

	10.5	Neither party may assign or otherwise transfer this Agreement in whole or in part without the prior written consent of the other party. 

  

	10.6	The failure of either party to enforce at any time or for any period any one or more of the provisions of this Agreement shall not be a waiver of them or of the right to at any time
subsequently to enforce any or all of the provisions of this Agreement. 

  

	10.7	The parties acknowledge that this Agreement, together with the Appendices hereto contains the entire agreement between the parties relating to the subject matter hereof and that
they have not relied upon any oral or written representation, warranty term, condition or understanding not set out in this Agreement. 

  

	10.8	Any notice to be served by either of the parties on the other shall be sent by prepaid recorded delivery, or if sent by electronic means, shall be confirmed by such prepaid recorded
delivery, to the address set out at the head of this Agreement or to such other address that may from time to time be notified in writing to the other. 

 Any notice addressed to RFUCMS shall be marked for the attention of: 
 [***] 
 [***] 
 Any notice addressed
to BBB shall be marked for the attention of: 
 [***] 
 [***] 
  

	10.9	This agreement shall be construed in accordance with English Law. Any dispute arising out of or in connection with this Agreement, including any question regarding its existence,
validity or termination, shall be referred to and finally resolved by arbitration under the Rules of the London Court of International Arbitration (“LCIA”), which Rules are deemed to be incorporated by reference into this clause. The
number of arbitrators shall be three, with each party selecting one arbitrator and the two arbitrators selecting the third. The place of arbitration shall be London, England. The language to be used in the arbitral proceedings shall be English. The
governing law of the contract shall be the substantive law of England. The cost thereof shall be borne in full by the party held to be the offending party. 

  

					
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the Commission. 

  

 IN WITNESS WHEREOF the parties have appended hereto the signatures of their authorised signatories as of the date first
above written. 
  

									
	 For and on behalf of
 University College London
	 		 	 For and on behalf of
 Big Bear Bio
Inc

					
	Signed	 	/s/ C.A. Tarhan	 		 	Signed	 	/s/ Yoshinari Kumagai
					
	 Name and Title 
	 	C.A. Tarhan, Finance Director and Head of Administration	 		 	 Name and Title 
	 	Yoshinari Kumagai, President & CEO
					
	 Date
	 	14/4/99	 		 	 Date
	 	14/4/99

  

					
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 APPENDIX I 
 Research Plan 
 [***] 
  

					
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the Commission. 

  

 APPENDIX II 
 Project Costings 
 [***] 
  

					
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	***	Confidential treatment request pursuant to a request for confidential treatment filed with the Securities and Exchange Commission. Omitted portions have been filed separately with
the Commission.

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