Document:

EX-10.24

 Exhibit 10.24 

AMENDMENT NO. 1 TO LICENSE AND SERVICES AGREEMENT 

This AMENDMENT NO. 1 TO LICENSE AND SERVICES AGREEMENT (herein referred to as “Amendment No. 1”) is made and
entered into as of this September 4th, 2012 (the “Amendment No. 1 Effective Date”), by and between Ultragenyx Pharmaceutical, Inc. (herein referred to as “Ultragenyx”), a California Corporation, and The
Buck Institute for Research on Aging, an independent non-profit research organization organized under the laws of California (“Buck”), each herein referred to individually as “Party” and collectively as
“Parties”. 
 WHEREAS, Ultragenyx and Buck are Parties to the Agreement (as defined below),
pursuant to which Ultragenyx has rights to use certain Buck facilities, specifically laboratory and write-up space; and 

WHEREAS, the Parties now desire to amend the Agreement to provide for Ultragenyx’s use of a newer, larger
laboratory, storage, write-up area and potential expansion laboratory space. 
 NOW, THEREFORE, the
Parties agree as follows: 
  

	1.	This Amendment No. 1 shall serve as an amendment to that certain License and Services Agreement (the “Agreement”), effective September 24, 2010, by and between Buck and Ultragenyx. Except as
expressly modified hereby, the Agreement shall continue in full force according to its terms. Capitalized terms not otherwise defined in this Amendment No. 1 shall have the meaning ascribed to such term in the Agreement. 

 

	2.	Recital B of the Agreement is hereby deleted and replaced in its entirety with 

B. Buck is an expanding biomedical research institute dedicated to research and education on the biology of aging and
age-related disease and has a full laboratory facility and set of core services, including, but not limited to a Microscopy and Imaging Core, Genetics Core and an AALAC accredited Vivarium (the “Facility”); 

 

	3.	Recital C of the Agreement shall be deleted in its entirety and replaced with the following: 

C. Ultragenyx wishes to procure access at the Facility to certain laboratory space in Building A of the Facility, Fourth Floor,
as shown on the attached Exhibit “A” as “Licensed Lab Space” and also have a right of first refusal to lease the “Expansion Space” also shown in Exhibit “A” in order to conduct research and facilitate its
therapeutic development programs; and 
  

	4.	Section 2 of the Agreement shall be deleted in its entirety and replaced with the following: 

“Term. The term of this Agreement (“Term”) shall be for two (2) years from the Amendment No. 1 Effective Date,
except that (i) either party may terminate this Agreement upon one year’s prior written notice without cause and purely out of convenience of such party; and (ii) either party may terminate this Agreement for cause

  
 -1- 

 AMENDMENT NO. 1 TO LICENSE AND SERVICES AGREEMENT 

 

 
upon a breach as specified below. Within ninety (90) days prior to the expiry of the Term, Ultragenyx may extend the Term by an additional twelve (12) months (the “Option”) by
sending written notice to Buck. Ultragenyx may exercise the Option for up to three (3) consecutive years.” 
  

	5.	The first sentence of the second paragraph of Section 3 is hereby deleted and replaced in its entirety with the following: 

“Ultragenyx proposed to pursue laboratory research within the Licensed Lab Space and place four (or more, as approved and trained by Buck
in environmental safety, fire codes and provisioned with Facility-access key cards) staff/employees (“Agents”) at the Facility to conduct research for Ultragenyx, and these Agents will require access to the following (i) parking at
the Facility parking lot; (ii) the Licensed Lab Space; and (iii) the Amenities, to the extent these are available.” 
  

	6.	The first sentence of the first paragraph of Section 4( a) is hereby deleted and replaced in its entirety with the following: 

“Subject to the payment of the License Fees described in Section 6, below, and to the terms and conditions of this Agreement, for the
duration of the Term, Buck hereby grants to Ultragenyx a non-exclusive license to access and use the parking; the Public Areas; the Amenities; and the Licensed Lab Space for its Agents.” 

 

	7.	The following shall be added as Section 4(d): 

 “(d) Ultragenyx shall have the option
at any time during the Term to license all or part of the Expansion Space on the same terms and conditions as contained in this Agreement (and coterminous with the Term) except at a fee to be negotiated, on a per square foot basis no greater than
five percent (5%) higher than the fee paid at the time Ultragenyx exercises the option (the “Option”); provided that the space in the Expansion Space that is occupied at the Amendment No. 1 Effective Date (i.e., the stem cell
training area) shall be included in the Expansion Space only if vacated by the current occupants at the time of exercise of the Option. Ultragenyx may exercise the Option by providing Buck ninety (90) days prior written notice of its intent to
license the Expansion Space or part thereof. The parties shall enter into an amendment to this Agreement or new agreement, as appropriate, to reflect the license of the Expansion Space on such terms within such ninety day period. If during the Term
and prior to the exercise of the Option by Ultragenyx, a potential tenant, other than the Buck itself, (“Potential Tenant”) expresses definitive written interest in licensing or leasing part or all of the Expansion Space, Buck will send
written notice to Ultragenyx. Ultragenyx shall have sixty (60) days after receipt of such notice to exercise the Option. If Ultragenyx does not exercise the Option within such 60 day period, the Option will be considered terminated and
Ultragenyx will have no further contractual right to the Expansion Space.” 

  
 -2- 

 AMENDMENT NO. 1 TO LICENSE AND SERVICES AGREEMENT 

 

	8.	In Section 6 of the Agreement, the numbers $33,600 and $2,800.00 are hereby deleted and replaced with the numbers $60,000 and $5,000.00, respectively. 

 

	9.	The following shall be added at the end of the Section 6 of the Agreement: 

 “This
License Fee will remain in effect for the first twelve months following the Amendment No. 1 Effective Date and shall be subject to an increase based on multiplying the percent change of the Producer Pricing Index from the previous twelve month
period to the License Fee charged in the preceding year, but in no case shall the License Fee be lower than at the stated first year rate. Such increase will take effect and be adjusted immediately on the first and subsequent anniversaries of the
Amendment No. 1 Effective Date.” 
  

	10.	Exhibit A of the Agreement is hereby deleted and replaced in its entirety with Attachment No. 1 hereto. 

  

	11.	This Amendment No. 1 shall inure to the benefit of and be binding upon the Parties hereto and their respective heirs, successors, trustees, transferees and assigns. 

 

	12.	This Amendment No. 1 may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

IN WITNESS WHEREOF, the Parties hereto, intending to be legally bound hereby, have caused this Amendment No. 1 to be executed and delivered by their
proper and duly authorized officers effective on the Amendment No. 1 Effective Date. 
  

									
	ULTRAGENYX, INC.	 		 	BUCK INSTITUTE FOR RESEARCH ON AGING
					
	 BY:
	 	/S/ SHALINI SHARP	 		 	BY:	 	/S/ REMY GROSS, III

									
	 PRINTED NAME:
	 	SHALINI SHARP	 		 	PRINTED NAME:	 	REMY GROSS, III

									
	TITLE:	 	CFO	 		 	TITLE:	 	VICE PRESIDENT, BUSINESS DEVELOPMENT

  
 -3-EX-4.1

 Exhibit 4.1 
  

 
 ORDINARY SHARES 
NOMINAL
VALUE $0.01 
Oxford Immunotec 
ORDINARY SHARES 
THIS CERTIFICATE IS TRANSFERABLE 
IN CANTON, MA, JERSEY CITY, NJ AND 
COLLEGE STATION, TX 
Certificate 
Number 
ZQ00000000 
Shares 
* * 000000* * * * * * * * * * * * * * * * * * 
* * * 000000* * * * * * * * * * * * * * * * * 
* * * * 000000* * * * * * * * * * * * * * * *

* * * * * 000000* * * * * * * * * * * * * * * 
* * * * * * 000000* * * * * * *
* * * * * * * 
OXFORD IMMUNOTEC GLOBAL PLC 
INCORPORATED UNDER THE LAWS OF
ENGLAND AND WALES WITH COMPANY NUMBER 8654254 
THIS CERTIFIES THAT 
MR.
SAMPLE & MRS. SAMPLE & 
MR. SAMPLE & MRS. SAMPLE 
CUSIP
XXXXXX XX X 
SEE REVERSE FOR CERTAIN DEFINITIONS 
is the owner of 
***ZERO HUNDRED THOUSAND 
ZERO HUNDRED AND ZERO*** 
FULLY-PAID AND NON-ASSESSABLE SHARES OF ORDINARY SHARES OF 
Oxford Immunotec Global Plc
transferable in accordance with, and subject to, the Company’s articles of association on the books of the Company in person or by duly authorized attorney upon surrender of this certificate properly endorsed. This certificate is not valid
unless countersigned by the Transfer Agent and registered by the Registrar. 
Witness the facsimile signatures of its duly authorized officers. 
Chairman 
Secretary 
DATED DD-MMM-YYYY 
COUNTERSIGNED AND REGISTERED: 
COMPUTERSHARE TRUST COMPANY, N.A. 
TRANSFER AGENT AND REGISTRAR, 
By 
AUTHORIZED SIGNATURE 
SECURITY INSTRUCTIONS ON REVERSE 
1234567 

  

OXFORD IMMUNOTEC GLOBAL PLC 
 A FULL STATEMENT OF THE POWERS,
DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER SPECIAL RIGHTS OF EACH CLASS OF SHARES OF THE COMPANY OR SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES AND/OR RIGHTS WILL BE FURNISHED
BY THE COMPANY WITHOUT CHARGE TO ANY SHAREHOLDER WHO SO REQUESTS UPON APPLICATION TO THE TRANSFER AGENT NAMED ON THE FACE HEREOF OR TO THE OFFICE OF THE SECRETARY OF THE COMPANY. THE TRANSFER OF THESE SHARES REPRESENTED BY THIS CERTIFICATE REQUIRES
THE COMPLETION OF A SPECIALIZED STOCK TRANSFER FORM AND MAY BE SUBJECT TO THE UNITED KINGDOM’S HM REVENUE AND CUSTOMS STAMP DUTY. PLEASE CONTACT THE TRANSFER AGENT FOR ADDITIONAL INFORMATION. 

 

							
	 For US
purposes the following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations:

	  

TEN COM
	 	  
 - as tenants in common
	 	  
 UNIF GIFT MIN ACT
	 	  

-                       
                       Custodian                
                       

	 	 		 		 	            (Cust)             
                                 (Minor)       
         
	 TEN ENT
	 	- as tenants by the entireties	 		 	under Uniform Gifts to Minors Act                
                               
	 	 		 		 	(State)                  
	 JT TEN
	 	- as joint tenants with right of survivorship	 	UNIF TRF MIN ACT 	 	-                  
                    Custodian (until age               
                )
	 	 	  and not as tenants in common	 		 	(Cust)                         
                                         
                
	 	 		 		 	                    under Uniform 
Transfers to Minors Act                 
	 	 		 		 	(Minor)                         
                                         
   (State)    
	
Additional abbreviations may also be used though not in the above list.

  

					
		 		  	PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE
	For value received,                          
                hereby sell, assign and transfer unto	 	 	  	     
	 	  
		 		  	 

  
  

(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE) 
  

 
  
  

 
  
  

			
	  
	 	Shares

 of the Ordinary Shares represented by the within Certificate, and do hereby irrevocably constitute and appoint 

 

			
	  
	 	Attorney

 to transfer the said stock on the books of the within-named Company with full power of substitution in the premises. 

 

													
	 Dated: 
	 	  
	 	20	 	  
	 	 	 	 Signature(s) Guaranteed:
Medallion Guarantee Stamp
 THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and Loan
Associations and Credit Unions) WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15.

	  
 Signature:
	 	  
	 	 	 
	  
 Signature:
	 	  
	 	 	 
		 	Notice:	 	The signature to this assignment must correspond with the name as written upon the face of the certificate, in every particular, without alteration or enlargement, or any change
whatever.	 	 	 
		 		 		 		 		 	 	 
		 		 		 		 		 	 	 
		 		 		 		 		 	 	 
		 		 		 		 		 		 	 

			
		 	 The IRS requires that we report the cost basis of certain shares acquired after January 1, 2011. If your shares were covered by the
legislation and you have sold or transferred the shares and requested a specific cost basis calculation method, we have processed as requested. If you did not specify a cost basis calculation method, we have defaulted to the first in, first out
(FIFO) method. Please visit our website or consult your tax advisor if you need additional information about cost basis.
  

If you do not keep in contact with us or do not have any activity in your account for the time periods specified by state law, your property could become
subject to state unclaimed property laws and transferred to the appropriate state.

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