Document:

Amendment to Management Deferred Compensation Plan

 Exhibit 10.20 
  
 AMENDMENT NO. 2 
 TO 
 BUFFALO WILD WINGS, INC. 
 MANAGEMENT DEFERRED COMPENSATION PLAN 
  
 The Buffalo Wild Wings, Inc. Management Deferred Compensation Plan (the “Plan”) adopted May 20, 1999, amended January 1, 2002, was amended by the Board of Directors on December 4, 2003 to permit a lump sum
payment of any balance owed to an individual participant at any time that such balance is less than $20,000. Section 4.2.2 of the Plan is amended and restated in its entirety as follows: 
  
 “4.2.2 Acceleration or Change in Manner of Payment. Notwithstanding Section 4.2.1, the Board, in its
sole discretion and after consultation with the payee, may accelerate payments or make payments in a different manner if it determines that such acceleration or change in the manner of payment would be in the best interest of the payee; provided,
however, that such payment on the first payment date shall not exceed 50% of the vested value of the participant’s account. Notwithstanding the foregoing, the Board may authorize a lump sum payment of any balance owed to an individual
participant at any time if such balance is less than $20,000.” 
  
 Except as amended herein, all provisions of the Plan shall remain in full force and effect. 
  
 This Amendment has been executed by its duly authorized officer as of this 4th day of December, 2003. 
  

			
	BUFFALO WILD WINGS, INC.
		
	 By:
	 	 /S/    JAMES M.
SCHMIDT        

	 	 	 James M. Schmidt
 Senior Vice President, General CounselForm of Nuvelo, Inc. Common Stock Certificate.

 Exhibit 4.1 
  

					
	[SEAL]	 	[LOGO OF NUVELOTM]	 	[SEAL]
	 	 	 	 	 
	COMMON STOCK	 	INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE	 	SEE REVERSE FOR CERTAIN DEFINITIONS AND A STATEMENT AS TO THE RIGHTS, PREFERENCES, PRIVILEGES AND RESTRICTIONS OF SHARES

  

					
	THIS CERTIFIES THAT	 	 	 	 CUSIP 67072M 30 1

	 	 	 	 	 
	 	 	 	 	 
	is the owner of	 	 	 	 
	  
 FULLY PAID AND NON-ASSESSABLE SHARES OF THE
COMMON STOCK, $0.001 PAR VALUE, OF
  
 NUVELO,
INC.
  
 transferable on the books of the Corporation by the
holder hereof in person or by duly authorized attorney upon surrender of this Certificate properly endorsed. This Certificate is not valid until countersigned and registered by the Transfer Agent and Registrar.
  
 WITNESS the facsimile seal of the Corporation and the facsimile
signatures of its duly authorized officers.

  

							
	 DATED
	  	 	  	 	  	 
	 /s/    Ted W. Love
 PRESIDENT
	  	[SEAL OF NUVELO]	  	 	  	 COUNTERSIGNED AND
REGISTERED:
 U.S.
STOCK TRANSFER
CORPORATION
 TRANSFER AGENT AND
REGISTRAR

	 	  	  	 	  
	 	  	  	 	  
	 /s/    Peter S. Garcia
	  	  	 	  	 
	SECRETARY	  	  	By	  	  

	 	  	  	 	  	AUTHORIZED SIGNATURE

 NUVELO, INC. 
  
 The Corporation will furnish to any stockholder, upon request and without charge, a statement of the powers, designations,
preferences and relative, participating, optional or other special rights of each class of stock or series thereof and the qualifications, limitations or restrictions of such preferences and/or rights. Any such request should be addressed to the
Secretary of the Corporation at its principal office. 
  
 The
following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations. 
  

																	
	 TEN COM
	 	 —
	 	 as tenants in common
	  	 	  	UNIF GIFT MIN ACT	  	—	  	                                       
      
Custodian                                      
       

	 TEN ENT
	 	 —
	 	 as tenants by the entireties
	  	 	  	 	  	 	  	    (Cust)        	  	(Minor)                
	 JT TEN
	 	 —
	 	as joint tenants with right of survivorship and not as tenants in common	  	 	  	 	  	 	  	 under Uniform Gifts to Minors
 Act                                      
                                        
   
 (State)

	 	 	 	 	 	  	 	  	UNIF TRF MIN ACT	  	—	  	                                 
Custodian (until age                                
 )

	 	 	 	 	 	  	 	  	 	  	 	  	             (Cust)
	  	 	  	 
	 	 	 	 	 	  	 	  	 	  	 	  	                     
under Uniform Transfers

	 	 	 	 	 	  	 	  	 	  	 	  	     (Minor)

	 	 	 	 	 	  	 	  	 	  	 	  	 To Minor Act
                                       
 

	 	 	 	 	 	  	 	  	 	  	 	  	(State)                

  
 Additional
abbreviations may also be used though not in the above list. 
  
 FOR VALUE RECEIVED,
                                        
hereby sell, assign and transfer unto 
  
 PLEASE INSERT SOCIAL SECURITY OR OTHER

         IDENTIFYING NUMBER OF ASSIGNEE 
  
  

			
	  

	(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)
	  

	  

	  

	 	Shares
	 of the Common Stock represented by the within Certificate, and do hereby irrevocably constitute and appoint

	  

	 	Attorney
	 to transfer the said stock on the books of the within named Corporation with full power of substitution in the premises.
	 	 
		
	 Dated
                                        
                    
	 	 

  

					
	 	 	  

	 	 
			
	 	 	  

	 	 
	NOTICE:	 	THE SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME(S) AS WRITTEN UPON THE FACE OF THE CERTIFICATE, IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE
WHATEVER	 	 

  

			
	 Signature(s) Guaranteed:
	 	 
		
	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE
GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C RULE 17Act-16	 	 

  
 This certificate also
evidences and entitles the holder hereof to certain Rights as set forth in a Rights Agreement between Nuvelo, Inc. and U.S. Stock Transfer Corporation, dated as of June 5, 1998, as the same may be amended from time to time (the “Rights
Agreement”), the terms of which are hereby incorporated herein by reference and a copy of which is on file at the principal executive offices of Nuvelo, Inc. Under certain circumstances, as set forth in the Rights Agrement, such Rights will be
evidenced by separate certificates and will no longer be evidenced by this certificate. Hyseq, Inc. will mail to the holder of this certificate a copy of the Rights Agreement without charge after receipt of a written request therefor. As described
in the Rights Agreement, Rights which are held by or have been held by Acquiring Persons or Associates or Affiliates thereof (as defined in the Rights Agreement) shall become null and void.Amendment to Rights Agreement, dated as of March 19, 2004,

 Exhibit 4.4 
  

RIGHTS AGREEMENT AMENDMENT 
  
 This Amendment, dated as of March 19, 2004, to the Rights Agreement, dated as of June 5, 1998, as amended as of November 9, 2002 (the “Rights
Agreement”), is between Nuvelo, Inc., a Nevada corporation (the “Company”), formerly known as Hyseq, Inc., and U.S. Stock Transfer Corporation, as Rights Agent (the “Rights Agent”). 
  
 WHEREAS, the Company and the Rights Agent have heretofore executed and
entered into the Rights Agreement; 
  
 WHEREAS, pursuant to
Section 26 of the Rights Agreement, the Company and the Rights Agent may from time to time supplement or amend the Rights Agreement in accordance with the provisions of Section 26 thereof and the Company desires and directs the Rights Agent to so
amend the Rights Agreement; and 
  
 WHEREAS, all acts and things
necessary to make this Amendment a valid agreement according to its terms have been done and performed, and the execution and delivery of this Amendment by the Company and the Rights Agent have been in all respects authorized by the Company and the
Rights Agent. 
  
 NOW THEREFORE, in consideration of the foregoing
premises and mutual agreements set forth in the Rights Agreement and this Amendment, the parties hereto agree as follows: 
  
 1. Effective as of the effective time (the “Reincorporation Time”) of the merger of the Company with and in to Nuvelo, Inc., a Delaware
corporation and a wholly owned subsidiary of the Company, the first recital of the Rights Agreement is modified and amended by deleting “Series B” and inserting in lieu thereof “Series A”. 
  
 2. Section 3.4 of the Rights Agreement is hereby modified and amended as
follows: 
  
 (a) by deleting the word “Hyseq” wherever
it appears and inserting in lieu thereof the word “Nuvelo”; and 
  
 (b) by inserting immediately after the words “With respect to certificates containing the foregoing legend” and before the comma the words “or any similar legend relating to one or more of the
Company’s predecessors in interest”. 
  
 3. Section 7.1
of the Rights Agreement is hereby modified and amended by inserting immediately after the number “13.2” and before the comma the following parenthetical: “(excluding the merger of Nuvelo, Inc., a Nevada corporation, with and into
Nuvelo, Inc., a Delaware corporation (the “REINCORPORATION”) and all agreements related thereto)”. 
  
 4. Section 13.2 of the Rights Agreement is hereby modified and amended by inserting immediately after the number “7.1” and before the period the
following: “; provided, however, that this Rights Agreement and the rights of the holders of Rights hereunder shall not be terminated in connection with the Reincorporation, but shall remain in full force and effect”

 5. Section 24 of the Rights Agreement is hereby modified and amended by inserting immediately prior to
the period at the end of the first paragraph thereof the following: “; provided, however, that no such notice shall be required in connection with the Reincorporation”. 
  
 6. Effective as of the Reincorporation Time, Section 25 of the Rights
Agreement is modified and amended as follows: 
  
 (a) by deleting
the word “Hyseq” and inserting in lieu thereof the word “Nuvelo”; and 
  
 (b) by deleting the number “670” and inserting in lieu thereof the number “675”. 
  
 7. Section 28 of the Rights Agreement is hereby modified and amended by inserting at the end thereof the following: 
  
 “Without limiting the foregoing, effective upon the effective time of
the Reincorporation, all the covenants and provisions of this Rights Agreement by or for the benefit of the Company shall bind and inure to the benefit of the surviving company in the Reincorporation, and such company shall be deemed to be the
Company for all purposes hereunder.” 
  
 8. Effective as of
the Reincorporation Time, Exhibit A of the Rights Agreement is modified and amended by deleting it in its entirety and inserting in lieu thereof the text attached as Annex A hereto. 
  
 9. Effective as of the Reincorporation Time, Exhibit B of the Rights Agreement is modified and amended as follows:

  
 (a) by deleting the word “Hyseq” wherever it
appears and inserting in lieu thereof the word “Nuvelo”; 
  
 (b) by deleting the word “Nevada” wherever it appears and inserting in lieu thereof the word “Delaware”; and 
  
 (c) by deleting “Series B” wherever it appears and inserting in lieu thereof “Series A”. 
  
 10. Except as expressly amended hereby, the Rights Agreement remains in full
force and effect in accordance with its terms. This Amendment to the Rights Agreement shall be governed by and construed in accordance with the laws of the State of Delaware. This Amendment to the Rights Agreement may be executed in any number of
counterparts and each of such counterparts shall for all purposes be deemed an original, and all such counterparts shall together constitute but one and the same instrument. 
  

 2 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to the Rights Agreement to be duly
executed as of the day and year first above written. 
  

			
	 NUVELO, INC.

	 (formerly known as Hyseq, Inc.)

		
	 By:
	 	 /s/ Ted W. Love

	 Name:
	 	 Ted W. Love

	 Title:
	 	 President and Chief Executive Officer

	
	 U.S. STOCK TRANSFER CORPORATION

	 as Rights Agent

		
	 By:
	 	 /s/ Richard Tilton

	 Name:
	 	 Richard Tilton

	 Title:
	 	 Assistant Vice President

  

 3 

 ANNEX A 
  
 NUVELO, INC. 
  
 CERTIFICATE OF DESIGNATIONS 
 OF 
 SERIES A JUNIOR PARTICIPATING PREFERRED STOCK 
  
 SETTING FORTH 
 THE POWERS,
PREFERENCES, RIGHTS, QUALIFICATIONS, 
 LIMITATIONS AND RESTRICTIONS OF 
 SUCH SERIES OF PREFERRED STOCK 
  
 Nuvelo, Inc. (the “Corporation”), a corporation organized and existing under the General Corporation Law of the State of Delaware, DOES HEREBY CERTIFY: 
  
 That pursuant to the authority conferred upon the Board of Directors by the
Corporation’s Amended and Restated Certificate of Incorporation (the “Certificate of Incorporation”), in accordance with the provisions of Section 151 of the General Corporation Law of the State of Delaware, the Board of
Directors of the Corporation, on March 19, 2004, adopted a resolution providing for the issuance of up to 100,000 shares of Series A Junior Participating Preferred Stock, par value $0.001 per share, with the following designations, preferences and
relative, participating, optional or other rights and the qualifications, limitations and restrictions: 
  
 Series A Junior Participating Preferred Stock: 
  
 Section 1. Designation and Amount. The shares of such series shall be designated as Series A Junior Participating Preferred Stock (the
“Series A Junior Preferred Stock”) and the authorized number of shares constituting the Series A Junior Preferred Stock shall be 100,000. Such number of shares may be increased or decreased by resolution of the Board of Directors;
provided, that no decrease shall reduce the number of shares of Series A Junior Preferred Stock to a number less than the number of shares then outstanding plus the number of shares reserved for issuance upon the exercise of outstanding options,
rights, or warrants or upon the conversion of any outstanding securities issued by the Corporation convertible into Series A Junior Preferred Stock. 
  
 Section 2. Dividends and Distributions. (a) Subject to the rights of the holders of any shares of any series of Preferred Stock (or any similar
stock) ranking prior and superior to the Series A Junior Preferred Stock with respect to dividends, the holders of shares of Series A Junior Preferred Stock, in preference to the holders of Common Stock, par value $0.001 per share (the
“Common Stock”), of the Corporation, and of any other junior stock, shall be entitled to receive, when, as and if declared by the Board of Directors out of funds legally available for the purpose, quarterly dividends payable in cash
on the first day of March, June, September and 

 
December in each year (each such date being referred to herein as a “Quarterly Dividend Payment Date”), commencing on the first
Quarterly Dividend Payment Date after the first issuance of a share or fraction of a share of Series A Junior Preferred Stock, in an amount per share (rounded to the nearest cent) equal to the greater of (a) $1.00 or (b) subject to the provision for
adjustment hereinafter set forth, 1,000 times the aggregate per share amount of all cash dividends, and 1,000 times the aggregate per share amount (payable in kind) of all non-cash dividends or other distributions, other than a dividend payable in
shares of Common Stock or a subdivision of the outstanding shares of Common Stock (by reclassification or otherwise), declared on the Common Stock since the immediately preceding Quarterly Dividend Payment Date or, with respect to the first
Quarterly Dividend Payment Date, since the first issuance of any share or fraction of a share of Series A Junior Preferred Stock. In the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of
Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of
Common Stock, then in each such case the amount to which holders of shares of Series A Junior Preferred Stock were entitled immediately prior to such event under clause (1) of the preceding sentence shall be adjusted by multiplying such amount by a
fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding immediately prior to such event. 

 
 (b) The Corporation shall declare a dividend or distribution on the Series
A Junior Preferred Stock as provided in paragraph (a) of this Section 2 immediately after it declares a dividend or distribution on the Common Stock (other than a dividend payable in shares of Common Stock); provided that, in the event no dividend
or distribution shall have been declared on the Common Stock during the period between any Quarterly Dividend Payment Date and the next subsequent Quarterly Dividend Payment Date, a dividend of per share on the Series A Junior Preferred Stock shall
nevertheless be payable on such subsequent Quarterly Dividend Payment Date. 
  
 (c) Dividends shall begin to accrue and be cumulative on outstanding shares of Series A Junior Preferred Stock from the Quarterly Dividend Payment Date next preceding the date of issue of such shares, unless the date
of issue of such shares is prior to the record date for the first Quarterly Dividend Payment Date, in which case dividends on such shares shall begin to accrue from the date of issue of such shares, or unless the date of issue is a Quarterly
Dividend Payment Date or is a date after the record date for the determination of holders of shares of Series A Junior Preferred Stock entitled to receive a quarterly dividend and before such Quarterly Dividend Payment Date, in either of which
events such dividends shall begin to accrue and be cumulative from such Quarterly Dividend Payment Date. Accrued but unpaid dividends shall not bear interest Dividends paid on the shares of Series A Junior Preferred Stock in an amount less than the
total amount of such dividends at the time accrued and payable on such shares shall be allocated pro rata on a share-by-share basis among all such shares at the time outstanding. The Board of Directors may fix a record date for the determination of
holders of shares of Series A Junior Preferred Stock entitled to receive payment of a dividend or distribution declared thereon, which record date shall be not more than 60 days prior to the date fixed for the payment thereof. 
  

 5 

 Section 3. Voting Rights. The holders of shares of Series A Junior Preferred Stock shall have the
following voting rights: 
  
 (a) Subject to the provision for
adjustment hereinafter set forth, each share of Series A Junior Preferred Stock shall entitle the holder thereof to 1,000 votes on all matters submitted to a vote of the Stockholders of the Corporation. In the event the Corporation shall at any time
declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise than by payment of a dividend in
shares of Common Stock) into a greater or lesser number of shares of Common Stock, in each such case the number of votes per share to which holders of shares of Series A Junior Preferred Stock were entitled immediately prior to such event shall be
adjusted by multiplying such number by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common Stock that were outstanding
immediately prior to such event. 
  
 (b) Except as otherwise
provided herein, in any other Certificate of Designations creating a series of Preferred Stock or any similar stock, or by law, the holders of shares of Series A Junior Preferred Stock and the holders of shares of Common Stock and any other capital
stock of the Corporation having general voting rights shall vote together as one class on all matters submitted to a vote of Stockholders of the Corporation. 
  
 (c) Except as set forth herein, or as otherwise provided by law, holders of Series A Junior Preferred Stock shall have no special voting rights and their
consent shall not be required (except to the extent they are entitled to vote with holders of Common Stock as set forth herein) for taking any corporate action. 
  

Section 4. Certain Restrictions. (a) Whenever quarterly dividends or other dividends or distributions payable on the Series A Junior Preferred
Stock as provided in Section 2 are in arrears, thereafter and until all accrued and unpaid dividends and distribution, whether or not declared, on shares of Series A Junior Preferred Stock outstanding shall have been paid in full, the Corporation
shall not: 
  
 (i) declare or pay dividends, or
make any other distributions, on any shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding up) to the Series A Junior Preferred Stock; 
  
 (ii) declare or pay dividends, or make any other distributions, on any shares of stock ranking on a parity
(either as to dividends or upon liquidation, dissolution or winding up) with the Series A Junior Preferred Stock, except dividends paid ratably on the Series A Junior Preferred Stock and all such parity stock on which dividends are payable or in
arrears in proportion to the total amounts to which the holders of all such shares are then entitled; 
  
 (iii) redeem or purchase or otherwise acquire for consideration shares of any stock ranking junior (either as to dividends or upon
liquidation, dissolution or winding 
  

 6 

 up) to the Series A Junior Preferred Stock, provided that the Corporation may at any time redeem,
purchase or otherwise acquire shares of any such junior stock in exchange for shares of any stock of the Corporation ranking junior (either as to dividends or upon dissolution, liquidation or winding up) to the Series A Junior Preferred Stock; or

  
 (iv) redeem or purchase or otherwise acquire
for consideration any shares of Series A Junior Preferred Stock, or any shares of stock ranking on a parity with the Series A Junior Preferred Stock, except in accordance with a purchase offer made in writing or by publication (as determined by the
Board of Directors) to all holders of such shares upon such terms as the Board of Directors, after consideration of the respective annual dividend rates and other relative rights and preferences of the respective series and classes, shall determine
in good faith will result in fair and equitable treatment among the respective series or classes. 
  
 (b) The Corporation shall not permit any subsidiary of the Corporation to purchase or otherwise acquire for consideration any shares of stock of the
Corporation unless the Corporation could, under subsection (a) of this Section 4, purchase or otherwise acquire such shares at such time and in such manner. 
  
 Section 5. Reacquired Shares. Any shares of Series A Junior Preferred Stock purchased or otherwise acquired by the Corporation in any manner
whatsoever shall be retired and canceled promptly after the acquisition thereof. All such shares shall upon their cancellation become authorized but unissued shares of Preferred Stock of the Corporation and may be reissued as part of a new series of
Preferred Stock of the Corporation, subject to the conditions and restrictions on issuance set forth herein, in the Certificate of Incorporation, or in any other Certificate of Designations creating a series of Preferred Stock or any similar stock
or as otherwise required by law. 
  
 Section 6. Liquidation,
Dissolution or Winding Up. Upon any liquidation, dissolution or winding up of the Corporation, no distribution shall be made (1) to the holders of shares of stock ranking junior (either as to dividends or upon liquidation, dissolution or winding
up) to the Series A Junior Preferred Stock unless, prior thereto, the holders of shares of Series A Junior Preferred Stock shall have received $1,000 per share, plus an amount equal to accrued and unpaid dividends and distributions thereon, whether
or not declared, to the date of such payment, provided that the holders of shares of Series A Junior Preferred Stock shall be entitled to receive an aggregate amount per share, subject to the provision for adjustment hereinafter set forth, equal to
1,000 times the aggregate amount to be distributed per share to holders of shares of Common Stock, or (2) to the holders of share of stock ranking on a parity (either as to dividends or upon liquidation, dissolution or winding up) with the Series A
Junior Preferred Stock, except distributions made ratably on the Series A Junior Preferred Stock and all such parity stock in proportion to the total amounts to which the holders of all such shares are entitled upon such liquidation, dissolution or
winding up. In the event the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by
reclassification or otherwise than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the aggregate 
  

 7 

 amount to which holders of shares of Series A Junior Preferred Stock were entitled immediately prior to such event under
the proviso in clause (1) of the preceding sentence shall be adjusted by multiplying such amount by a fraction the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is
the number of shares of Common Stock that are outstanding immediately prior to such event. 
  
 Section 7. Consolidation, Merger, etc. In case the Corporation shall enter into any consolidation, merger, combination or other transaction in which the shares of Common Stock are exchanged for or changed into
other stock or securities, cash and/or any other property, then in any such case each share of Series A Junior Preferred Stock shall at the same time be similarly exchanged or changed into an amount per share, subject to the provision for adjustment
hereinafter set forth, equal to 1,000 times the aggregate amount of stock, securities, cash and/or any other property (payable in kind), as the case may be, into which or for which each shares of Common Stock is changed or exchanged. In the event
the Corporation shall at any time declare or pay any dividend on the Common Stock payable in shares of Common Stock, or effect a subdivision, combination or consolidation of the outstanding shares of Common Stock (by reclassification or otherwise
than by payment of a dividend in shares of Common Stock) into a greater or lesser number of shares of Common Stock, then in each such case the amount set forth in the preceding sentence with respect to the exchange or change of shares of Series A
Junior Preferred Stock shall be adjusted by multiplying such amount by a fraction, the numerator of which is the number of shares of Common Stock outstanding immediately after such event and the denominator of which is the number of shares of Common
Stock that were outstanding immediately prior to such event. 
  
 Section 8. No Redemption. The shares of Series A Junior Preferred Stock shall not be redeemable. 
  
 Section 9. Rank. The Series A Junior Preferred Stock shall rank, with respect to the payment of dividends and the distribution of assets, junior to
all series of any other class of the Corporation’s preferred stock, except to the extent that any such other series specifically provides that it shall rank on a parity with or junior to the Series A Junior Preferred Stock. 
  
 Section 10. Amendment. The Certificate of Incorporation of the
Corporation shall not be amended in any manner which would materially alter or change the powers, preferences or special rights of the Series A Junior Preferred Stock so as to affect them adversely without the affirmative vote of the holders of at
least two-thirds of the outstanding shares of Series A Junior Preferred Stock, voting together as a single class. 
  
 [Signature Page Follows] 
  

 8 

 IN WITNESS WHEREOF, the above named officers, acting for and on behalf of Nuvelo, Inc. have
hereunto subscribed their names on this      day of March, 2004. 
  

			
	NUVELO, INC.
		
	 By:
	 	  

	 Name:
	 	 Ted W. Love

	 Title:
	 	 President

  
 Attest: 
  

			
	 By:
	 	  

	 Name:
	 	 Peter S. Garcia

	 Title:
	 	 Secretary

  

 9

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