Document:

Separation Agreement

 Exhibit 10.5 
 July 1, 2009 
 By Hand Delivery 
 Mr. Alexis Borisy 
 Dear Alexis: 
 As you have been notified, your employment with CombinatoRx, Incorporated (the “Company”) as its President and CEO will terminate, effective as of July 1, 2009 (the “Separation Date”). The purpose
of this letter is to confirm the agreement between you and the Company concerning your severance arrangements (the “Agreement”), as follows: 
 1. Final Salary, Vacation Pay and Pay in Lieu of Notice. 
 (a) On the Separation Date, you will
receive a check constituting all salary due to you through the Separation Date in addition to pay for the five (5) days of unused vacation accrued by you as of the Separation Date as reflected on the books of the Company. 
 (b) By no later than July 6, 2009, the Company shall pay to you the equivalent of 60 days of your Base Salary in lieu of notice of your termination other
than for Cause. 
 2. Consulting Arrangement. You and the Company have agreed that, on the date following the Separation Date, you
will commence the performance of consulting services for the Company under the terms of that certain Consulting Agreement dated July 1, 2009 between you and the Company (the “Consulting Agreement”), a copy of which is attached hereto
as Exhibit A. 
 3. Severance Benefits. In consideration of your acceptance of this Agreement and your continuing compliance with your
obligations hereunder, the Company will provide you the following severance pay and benefits: 
 (a) In accordance with the terms of the First
Amended Employment, Confidentiality and Non-Competition Agreement between you and the Company dated July 1, 

 
2004 as amended on December 12, 2008 (the “Employment Agreement”), the Company will pay you $932,500, constituting twenty-four months of your
base salary at the rate in effect as of the Separation Date, less applicable taxes and withholdings, payable in a single lump sum, on July 6, 2009. 
 (b) If you are enrolled in the Company’s medical and dental plans on the Separation Date, subject to your eligibility to continue such participation under applicable law and plan terms, the Company will pay 100%
of the premium cost of your continued participation in such plans for a period of up to twenty-four (24) months from the Separation Date. 
 (c) All options that you hold to purchase shares of the Company’s common stock pursuant to the terms of the Company’s 2000 Stock Option Plan, as amended, or the 2004 Amended and Restated Incentive Plan (either being the
“Plan”) that have not vested as of the Separation Date shall be deemed to have vested on the Separation Date and, subject to the terms of the applicable Plan, you shall have twenty-four (24) months from the Separation Date to exercise
all or any portion of such options, provided that in no event may the exercise date extend beyond the original maximum term of the option. 
 (d) The restrictions with respect to 100% of any restricted shares of the Company’s common stock that you may hold pursuant to the terms of the Plan that have not vested as of the Separation Date shall lapse as of the Separation Date.

 (e) Subject to the terms of the Retention Bonus letter agreement between you and the Company dated December 12, 2008 (the
“Retention Letter”), the Company shall pay you a lump sum amount of $150,000, less applicable deductions and withholdings on July 6, 2009. 
 (f) Your participation in all other employee benefit plans of the Company will end as of the Separation Date, in accordance with the terms of those plans, as amended from time to time. Among other things, you will not
continue to earn vacation or other paid time off after the Separation Date. 
 4. Withholding. All payments made by the Company under
this Agreement shall be reduced by any tax or other amounts required to be withheld by the Company under applicable law and all other deductions authorized by you. 
 5. Acknowledgement of Full Payment. You acknowledge and agree that the payments provided under paragraph 1 of this Agreement are in complete satisfaction of any and all compensation due to you from the Company,
whether for services provided to the Company or otherwise, through the Separation Date and that, except as expressly provided under this Agreement, no further compensation is owed to you. 
 6. Confidentiality and Non-Disparagement. You agree that you will not disclose this Agreement or any of its terms or provisions, directly or by
implication, except to members of your immediate family and to your legal and tax advisors, and then only on condition that they 

 
agree not to further disclose this Agreement or any of its terms or provisions to others. You also agree that you will not disparage or criticize the
Company, its business, its management or its products, and that you will not otherwise do or say anything that could disrupt the good morale of Company employees or harm its interests or reputation. 
 7. Return of Company Documents and Other Property. In signing this Agreement, you represent and warrant that you have returned to the
Company any and all documents, materials and information (whether in hardcopy, on electronic media or otherwise) related to Company business (whether present or otherwise) and all keys, access cards, credit cards, computer hardware and software,
telephones and telephone-related equipment and all other property of the Company in your possession or control. Further, you represent and warrant that you have not retained any copy of any Company documents, materials or information (whether in
hardcopy, on electronic media or otherwise). Recognizing that your employment with the Company has ended, you agree that you will not, for any purpose, attempt to access or use any Company computer or computer network or system, including without
limitation its electronic mail system. Further, you acknowledge that you have disclosed to the Company all passwords necessary or desirable to enable the Company to access all information which you have password-protected on any of its computer
equipment or on its computer network or system. Notwithstanding the foregoing, you and the Company agree that you may retain such property and maintain access as you and the Company agree is necessary to permit the performance of your obligations
under the Consulting Agreement.  
 8. Release of Claims. 
 (a) In exchange for the severance pay and benefits provided you under this Agreement, to which you would not otherwise be entitled absent your execution
of this Agreement, you, on your own behalf and that of your heirs, executors, administrators, beneficiaries, personal representatives and assigns, agree that this Agreement shall be in complete and final settlement of any and all causes of action,
rights or claims, whether known or unknown, that you have had in the past, now have, or might now have against the Company, any of its Affiliates, and/or all persons related thereto, including, without limitation, any and all causes of action,
rights or claims in any way related to, connected with or arising out of your employment or its termination or pursuant to Title VII of the Civil Rights Act, the Americans with Disabilities Act, Mass. Gen. Laws Chapter 151B, or any other federal,
state or local law, regulation or other requirement and you hereby release and forever discharge the Company and its Affiliates and all of their respective past, present and future directors, shareholders, officers, members, managers, general and
limited partners, employees, employee benefit plans, agents, representatives, successors and assigns, and all others connected with any of them, both individually and in their official capacities, from any and all such causes of action, rights or
claims. For purposes of this Agreement, “Affiliates” means all persons and entities directly or indirectly controlling, controlled by or under common control with the Company, where control may be by management authority, equity interest
or otherwise. This is a general release of all of your legally waivable claims, including but not limited to all of your claims arising under the Employment Agreement or the Retention Letter. 

 (b) This Agreement, including the release of claims set forth in the paragraph immediately above, creates
legally binding obligations and the Company therefore advises you to consider it carefully. In signing this Agreement, you give the Company assurance that you have signed it voluntarily and with a full understanding of its terms; that you have had
sufficient opportunity, before signing this Agreement, to consider its terms and to consult with an attorney, if you wished to do so, or to consult with any other of those persons to whom reference is made in the first sentence of paragraph 6 above;
and that, in signing this Agreement, you have not relied on any promises or representations, express or implied, that are not set forth expressly in this Agreement. 
 (c) This release does not include any claim which, as a matter of law, cannot be released by private agreement or that arises after the effective date of this Agreement. Nor does this release prohibit or bar you from
providing truthful testimony in any legal proceeding, or from cooperating with, or making truthful disclosures to any governmental agency charged with the enforcement of any employment laws. Notwithstanding the foregoing, with respect to any claim
that cannot be released by private agreement, you agree to release and waive your right (if any) to any monetary damages or other recovery (including, without limitation, attorneys’ fees) as to such claims, including any claims brought on your
behalf, either individually or as part of a collective action, by any governmental agency or other third party. 
 9. Litigation and
Regulatory Cooperation. You agree to reasonably cooperate with the Company in the defense or prosecution of any claims or actions now in existence or which may be brought in the future against or on behalf of the Company which relate to events
or occurrences that transpired while you were employed by the Company. Your reasonable cooperation in connection with such claims or actions shall include, but not be limited to, being available to meet with counsel to prepare for discovery or trial
and to act as a witness on behalf of the Company at mutually convenient times. You shall reasonably cooperate with the Company in connection with any investigation or review of any federal, state or local regulatory authority as any such
investigation or review relates to events or occurrences that transpired while you were employed by the Company pursuant to the Employment Agreement. You further agree that you shall not voluntarily provide information to or otherwise cooperate with
any individual or entity that is contemplating or pursuing litigation against the Company or any of its directors, officers, shareholders or employees or that is undertaking any investigation or review of any of their activities or practices;
provided, however, that you may participate in or otherwise assist in any investigation or inquiry conducted by the United States Equal Employment Opportunity Commission or the Massachusetts Commission Against Discrimination. The Company
shall reimburse you for any reasonable out-of-pocket expenses incurred in connection with your performance of obligations pursuant to this Section 9. 
 10. Acknowledgement of Continuing Obligations to the Company. You acknowledge that you have continuing obligations to the Company pursuant to the terms of Sections 7, 8, 9 and 10 of the Employment Agreement
that survive notwithstanding the termination of your employment by the Company. You hereby acknowledge those continuing obligations and agree to abide by them. 

 11. Miscellaneous. 
 (a) This Agreement constitutes the entire agreement between you and the Company and supersedes all prior and contemporaneous communications, agreements
and understandings, whether written or oral, with respect to your employment, its termination and all related matters, excluding only the following, which shall remain in full force and effect in accordance with their respective terms: (i) your
continuing obligations to the Company as set forth in Sections 7, 8, 9 and 10 of the Employment Agreement, (ii) the Company’s obligations to you, if any, under the terms set forth in Section 5(g)(ii) of the Employment Agreement;
(iii) the Consulting Agreement, and (iv) your and the Company’s rights and obligations under any plan or agreement with respect to the securities of the Company (including, without limitation, under any grant agreement or the Plan).

 (b) If any provision of this Agreement, or part thereof, is held invalid, void or voidable as against public policy or otherwise, the
invalidity shall not affect other provisions, or parts thereof, which may be given effect without the invalid provision or part. To this extent, the provisions and parts thereof of this Agreement are declared to be severable. Any waiver of any
provision of this Agreement shall not constitute a waiver of any other provision of this Agreement unless expressly so indicated otherwise. The language of all parts of this Agreement shall in all cases be construed according to its fair meaning and
not strictly for or against either of the parties. 
 (c) You may not assign any of your rights or delegate any of your duties under this
Agreement. The rights and obligations of the Company shall inure to the benefit of the Company’s successors and assigns. 
 (d) This
Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed to in writing by you and the SVP, General Counsel of the Company or his expressly authorized designee. The captions and headings in this Agreement
are for convenience only and in no way define or describe the scope or content of any provision of this Agreement. 
 (e) The obligation of
the Company to make payments to you or on your behalf under this Agreement is expressly conditioned upon your continued full performance of your obligations under this Agreement, including those under paragraphs 7, 8, 9 and 10 of the Employment
Agreement. 

 If the terms of this Agreement are acceptable to you, please sign, date and return it to me within five
(5) days of the date you received it. The enclosed copy of this letter, which you should also sign and date, is for your records. 
  

			
	Sincerely,
	
	COMBINATORX, INCORPORATED
		
	By:	 	 /s/ Jason F. Cole

		 	Jason F. Cole
		 	Senior Vice President and General Counsel

 Accepted and agreed: 
 I REPRESENT THAT I HAVE READ THE FOREGOING AGREEMENT, THAT I FULLY UNDERSTAND THE TERMS AND CONDITIONS OF SUCH AGREEMENT AND THAT I AM KNOWINGLY AND VOLUNTARILY EXECUTING THE SAME. IN ENTERING INTO THIS AGREEMENT, I DO NOT RELY ON ANY
REPRESENTATION, PROMISE OR INDUCEMENT MADE BY THE COMPANY OR ITS REPRESENTATIVES WITH THE EXCEPTION OF THE CONSIDERATION DESCRIBED IN THIS DOCUMENT. 
  

			
	Signature:	 	 /s/ Alexis Borisy

	Date:	 	 July 1, 2009Consulting Agreement

 Exhibit 10.6 
 CONSULTING AGREEMENT 
 THIS CONSULTING AGREEMENT (the “Agreement”) is made and entered into
this 1st day of July, 2009 (the “Effective Date”) by and between CombinatoRx, Incorporated, a Delaware corporation duly organized under law and having a usual place of business at 245 First Street, Cambridge, MA 02142 (hereinafter
referred to as the “Company”) and Alexis Borisy. 
 WHEREAS, the Consultant previously provided services to the Company as its
President and CEO pursuant to that First Amended Employment, Confidentiality and Non-Competition Agreement, dated as of July 1, 2004, as amended on December 12, 2008 (the “Employment Agreement”), 
 WHEREAS, the Company and the Consultant have agreed to terminate the Consultant’s employment relationship with the Company under the Employment
Agreement, and the Company wishes to engage the Consultant to provide the services described herein and Consultant agrees to provide the services for the compensation and otherwise in accordance with the terms and conditions contained in this
Agreement, 
 NOW THEREFORE, in consideration of the foregoing, and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, accepted and agreed to, the Company and the Consultant, intending to be legally bound, agree to the terms set forth below. 
 1. TERM. Commencing as of the Effective Date, and continuing until June 30, 2010 (the “Term”), unless earlier terminated pursuant to Section 5 hereof, the Consultant agrees that he will serve as a member of the
Company’s Scientific Advisory Board and as a consultant to the Company. This Agreement may be renewed or extended for any period as may be agreed by the parties. 
 2. DUTIES AND SERVICES. 
 (a) Consultant’s duties and responsibilities shall be as described in
Exhibit “A,” annexed hereto and made a part hereof (collectively, the “Duties” or “Services”). 
 (b) The
Consultant represents and warrants to the Company that he is under no contractual or other restrictions or obligations which are inconsistent with the execution of this Agreement, or which will interfere with the performance of his Duties.
Consultant represents and warrants that the execution and performance of this Agreement will not violate any policies or procedures of any other person or entity for which he performs Services concurrently with those performed herein. Consultant
understands and agrees that he will not bring to the Company or use in the performance of Consultant’s duties at the Company any materials or documents rightfully belonging to any other party which are not generally available to the public.
Consultant may bring such materials and documents to the Company provided Consultant has 

 
obtained written authorization from such other party for their possession and use. Further, Consultant agrees that he will not enter into any agreement
(either written or oral) which would put Consultant in conflict with this Agreement and/or require that he disclose Confidential Information. 
 (c) In performing the Services, Consultant shall comply, to the best of his knowledge, with all business conduct and regulatory and health and safety guidelines, policies and regulations established by the Company or any governmental
authority with respect to the Company’s business. 
 (d) Consultant represents that he has not been disbarred and, to the best of his
knowledge, is not under consideration for disbarment by the Food and Drug Administration from working in or providing services to any pharmaceutical or biotechnology company under the Generic Drug Enforcement Act of 1992. 
 3. CONSULTING FEE. 
 (a) Subject to the provisions
hereof, the Company shall pay Consultant a consulting fee as described in Appendix A. The Consultant shall submit monthly, on the Company’s standard reporting form, a listing of his hours, the Duties performed and a summary of his activities.
The Consulting Fee shall be paid within thirty (30) days of the Company’s receipt of the report and invoice. 
 (b) Consultant
shall be entitled to prompt reimbursement for all pre-approved expenses incurred in the performance of his Duties, upon submission and approval of written statements and receipts in accordance with the then regular procedures of the Company.
Pre-approval is required for expenses in excess of $500.00. 
 4. RELATIONSHIP OF THE PARTIES. 
 (a) The Consultant agrees that all Services will be rendered by him as an independent contractor and this Agreement is not to be interpreted as creating
an employment relationship between the Consultant and the Company or any of its Affiliates. It is agreed that, as an independent contractor, the Consultant will not attempt to bind the Company or any of its Affiliates to any obligation or pledge its
credit, unless expressly authorized in writing by the CEO or another expressly authorized representative of the Company. Affiliates means all natural persons and entities controlling, controlled by or under common control with the Company, where
control may be by management authority, contract or equity interest. 
 (b) Because the Consultant is an independent contractor with respect
to the Company, the consulting fees paid under this Agreement are not subject to withholding for Social Security, unemployment, Medicare, federal, state or local income or other taxes. All taxes and other legally required payments and any insurance
required by law shall be the sole responsibility of the Consultant. The Consultant agrees to pay all taxes, including self-employment taxes due in respect of the Consulting Fee and to indemnify the Company in the event the Company is required to pay
any such taxes on behalf of Consultant. 

 (c) As an independent contractor, neither the Consultant nor anyone claiming through the Consultant shall
be eligible to participate in, or receive benefits under, any bonus or other compensation plan or any stock option plan, employee benefit plan or other employee plan, program or arrangement of the Company or any of its Affiliates. 
 (d) The Consultant agrees and acknowledges that the Company will not maintain general liability or other insurance covering him. The Consultant will be
solely responsible for comprehensive general liability, automobile and other insurance and will assume all risk in connection with the adequacy of any and all such insurance which the Consultant elects to obtain. 
 5. EARLY TERMINATION OF THE TERM. 
 (a) This Agreement
may be terminated without cause by either party upon not less than thirty (30) days’ prior written notice by either party to the other. 
 (b) Upon termination under Section 5(a), neither party shall have any further obligations under this Agreement, except for the obligations which by their terms survive this termination as noted in Section 17 hereof. Upon
termination, and in any case upon the Company’s request, Consultant shall return immediately to the Company all Confidential Information and copies thereof. 
 6. CONTINUING OBLIGATIONS. The Consultant acknowledges that he has continuing obligations to the Company pursuant to the terms of Sections 7, 8, 9 and 10 of the Employment Agreement and pursuant to the terms of the letter
agreement with the Company dated July 1, 2009. The Consultant acknowledges those continuing obligations and agrees to abide by them. 
 7. PROPRIETARY
RIGHTS. 
 (a) Definitions. For the purposes of this Section 7, the terms set forth below shall have the following meanings:

 (i) Concept and Ideas. Those concepts and ideas disclosed by the Company to Consultant or which are first developed by Consultant
during the course of the performance of Services hereunder and which relate to the Company’s present, past or prospective business activities, services, and products, all of which shall remain the sole and exclusive property of the Company. The
Consultant shall have no publication rights, and all of the same shall belong exclusively to the Company. 
 (ii) Confidential
Information. For the purposes of this Agreement, Confidential Information shall mean and collectively include all information relating to the business, plans and/or technology of the Company including but not limited to technical information,
including inventions, methods, plans, processes, specifications, characteristics, assays, raw data, scientific preclinical or clinical data, records, databases, formulations, clinical protocols, equipment design, know-how, experience, and trade
secrets; developmental, 

 
marketing, sales, customer, supplier, consulting relationship information, operating, performance, and cost information; computer programming techniques;
microscopy technology and signal identification strategy whether in tangible or intangible form; and, all record bearing media containing or disclosing the foregoing information and techniques, including written business plans, patents and patent
applications, grant applications, notes, and memoranda, whether in writing or presented, stored or maintained in or by electronic, magnetic, or other means. 
 Notwithstanding the foregoing, the term “Confidential Information” shall not include any information which: (a) can be demonstrated to have been in the public domain or was publicly known or available
prior to the date of the disclosure to Consultant; (b) can be demonstrated in writing to have been rightfully in the possession of Consultant prior to the disclosure of such information to Consultant by the Company; (c) becomes part of the
public domain or publicly known or available by publication or otherwise, not due to any unauthorized act or omission on the part of Consultant; or (d) is supplied to Consultant by a third party without binder of secrecy, provided,
however, that such third party has no obligation to the Company or any of its Affiliates to maintain such information in confidence. 
 (b) Non-Disclosure to Third Parties. Except as required by Consultant’s Duties, Consultant shall not, at any time now or in the future, directly or indirectly, use, publish, disseminate or otherwise disclose any Confidential
Information, Concepts, or Ideas to any third party without the prior written consent of the Company which consent may be denied in each instance and all of the same, together with publication rights, shall belong exclusively to the Company.

 (c) Documents, etc. All documents, diskettes, tapes, procedural manuals, guides, specifications, plans, drawings, designs and
similar materials, lists of present, past or prospective customers, customer proposals, invitations to submit proposals, price lists and data relating to the pricing of the Company’s products and services, records, notebooks and all other
materials containing Confidential Information or information about Concepts or Ideas (including all copies and reproductions thereof) that come into Consultant’s possession or control by reason of Consultant’s performance of the
relationship, whether prepared by Consultant or others: (a) are the property of the Company; (b) will not be used by Consultant in any way other than in connection with the performance of his Duties; (c) will not be provided or shown
to any third party by Consultant; (d) will not be removed from the Company’s or Consultant’s premises (except as Consultant’s Duties require); and (e) at the termination (for whatever reason) of Consultant’s
relationship with the Company, or at such earlier time as requested by the Company, will be left with, or forthwith returned by Consultant to the Company. 
 (d) Patents, etc. The Consultant agrees that the Company is and shall remain the exclusive owner of the Confidential Information and Concepts and Ideas. Any interest in patents, patent applications, inventions,
technological innovations, trade names, trademarks, service marks, copyrights, copyrightable works, developments, discoveries, designs, processes, formulas, know-how, data and analysis, whether registrable or not (“Developments”), which
Consultant, as a result of rendering Services to the Company under this Agreement, may conceive or develop, shall: (i) forthwith be brought to the attention of the Company by Consultant and (ii) belong exclusively to the Company. No
license or conveyance of any such rights to the Consultant is granted or implied under this Agreement. 
  

 (e) Assignment. The Consultant hereby assigns and, to the extent any such assignment cannot be
made at present, hereby agrees to assign to the Company, without further compensation, all of his right, title and interest in and to all Concepts, Ideas, and Developments. The Consultant will execute all documents and perform all lawful acts which
the Company considers necessary or advisable to secure its rights hereunder and to carry out the intent of this Agreement. Consultant’s obligation to assist the Company in effecting such assignment(s), in any and all countries shall continue
beyond the termination or expiration of this Agreement. 
 8. EQUITABLE RELIEF. Consultant agrees that any breach of Sections 6 and 7 above by him
would cause irreparable damage to the Company and that, in the event of such breach, the Company shall have, in addition to any and all remedies of law, the right to an injunction, specific performance or other equitable relief to prevent the
violation or threatened violation of Consultant’s obligations hereunder, without the requirement of having to post bond. 
 9. WAIVER. Any waiver
by the Company of a breach of any provision of this Agreement shall not operate or be construed as a waiver of any subsequent breach of the same or any other provision hereof. All waivers by the Company shall be in writing. 
 10. SEVERABILITY; REFORMATION. In case any one or more of the provisions or parts of a provision contained in this Agreement shall, for any reason, be held to be
invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall not affect any other provision or part of a provision of this Agreement; and this Agreement shall, to the fullest extent lawful, be reformed and
construed as if such invalid or illegal or unenforceable provision, or part of a provision, had never been contained herein, and such provision or part reformed so that it would be valid, legal and enforceable to the maximum extent possible. Without
limiting the foregoing, if any provision (or part of a provision) contained in this Agreement shall for any reason be held to be excessively broad as to duration, activity or subject, it shall be construed by limiting and reducing it, so as to be
enforceable to the fullest extent compatible with then existing applicable law. 
 11. ASSIGNMENT. The Company shall have the right to assign its
rights and obligations under this Agreement to a party which assumes the Company’s obligations hereunder. Consultant shall not have the right to assign his rights or obligations under this Agreement without the prior written consent of the
Company. This Agreement shall be binding upon and inure to the benefit of the Consultant’s heirs and legal representatives in the event of his death or disability. 
 12. HEADINGS. Headings and subheadings are for convenience only and shall not be deemed to be a part of this Agreement. 
 13. AMENDMENTS. This Agreement may be amended or modified, in whole or in part, only by an instrument in writing signed by all parties hereto. 

 14. NOTICES. Any notices or other communications required hereunder shall be in writing and shall be deemed given
when delivered in person or when mailed, by certified or registered first class mail, postage prepaid, return receipt requested, addressed to the parties at their addresses specified in the preamble to this Agreement or to such other addresses of
which a party shall have notified the others in accordance with the provisions of this Section 14. 
 15. COUNTERPARTS. This Agreement may be
executed in two or more counterparts, each of which shall constitute an original and all of which shall be deemed a single agreement. 
 16. GOVERNING
LAW. This Agreement shall be construed in accordance with and governed for all purposes by the laws of the Commonwealth of Massachusetts applicable to contracts executed and wholly performed within such jurisdiction. Any dispute arising
hereunder shall be referred to and heard in only a court located in Massachusetts. 
 17. SURVIVAL. The provisions of Sections 6 to 10 and 16 to 17 of
this Agreement shall survive the expiration of the Term or the termination of this Agreement. This Agreement represents the entire agreement of the parties with respect to the subject matter of this Agreement and supersedes all prior agreements,
written or oral, between the Company and the Consultant relating to the subject matter of this Agreement. 
 EXECUTED, under seal, effective
as of the Effective Date. 
  

									
	COMBINATORX, INCORPORATED	 		 	 CONSULTANT

				
	By:	 	 /s/ Jason F. Cole
	 		 	 /s/ Alexis Borisy

	Name:	 	Jason F. Cole	 		 	Consultant:	 	Alexis Borisy
	Title:	 	Senior Vice President and General Counsel	 		 		 	
	 Hereunto Duly Authorized
	 		 		 	

 Appendix “A” 
 (A) Duties and Responsibilities: 
 During the Term, the Consultant agrees to perform Services of up to no more than
twenty (20) hours per month for the Company, as requested by the Company, including the following duties and tasks: Consultation in connection with the Company’s ongoing strategic collaboration with Novartis, and such other duties and
responsibilities, reasonably consistent with his position, as may be designated from time to time by the Board. The Consultant shall also serve as a member of the Company’s Scientific Advisory Board. 
 (B) Scheduling and Completion and Termination Dates: 
 This agreement
will be activated for the Term upon signing by both parties and can be renewed thereafter if mutually agreed upon. 
 (C) Fee Schedules and Payment
Dates: 
 The Company agrees to pay the consultant a fee of $350.00 per hour for consulting requested by the Company. Invoices for hours of service
should be sent monthly to the Company’s Chief Executive Officer or Chief Financial Officer. The Company may refuse to pay any invoices not provided to the Company within 60 days of the completion of Services.

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