Document:

Exhibit 4.1  

 

 

SHIRE
ACQUISITIONS INVESTMENTS IRELAND

 

DESIGNATED
ACTIVITY COMPANY

 

as Issuer

 

SHIRE
PLC

 

as Guarantor

 

BAXALTA
INCORPORATED

 

as
Subsidiary Guarantor

 

AND

 

DEUTSCHE
BANK TRUST COMPANY AMERICAS

 

as Trustee

 

_________________

 

SECOND
SUPPLEMENTAL INDENTURE

 

Dated
as of December 1, 2016

 

to the

 

INDENTURE

 

Dated
as of September 23, 2016

 

as
supplemented by the

 

FIRST
SUPPLEMENTAL INDENTURE

 

Dated
as of September 23, 2016

 

_________________

 

 

 

 

 

 

 

 

    

    

    

 

TABLE
OF CONTENTS

_________________

 

Page

 

	Article
    1 Definitions
	Section
    1.01.   Relation to Indenture	2
	Section
    1.02.   Definition of Terms	2
	Article
    2 Baxalta Guarantee
	Section
    2.01.   Baxalta Guarantee	3
	Section
    2.02.   Subrogation; Ranking	3
	Section
    2.03.   Limitation on Liability	4
	Section
    2.04.   Successors and Assigns	4
	Section
    2.05.   No Waiver	4
	Section
    2.06.   Release of Baxalta Guarantee	4
	Section
    2.07.   Modification of Indenture	5
	Article
    3 Miscellaneous
	Section
    3.01.   Ratification of Indenture	5
	Section
    3.02.   Transfer of Interest	5
	Section
    3.03.   Notices, Etc., to Baxalta	5
	Section
    3.04.   No Recourse Against Others	6
	Section
    3.05.   Trustee Not Responsible for Recitals	6
	Section
    3.06.   Governing Law	6
	Section
    3.07.   Waiver of Trial by Jury	6
	Section
    3.08.   Table of Contents, Headings, etc	6
	Section
    3.09.   Execution in Counterparts	6
	Section
    3.10.   Separability; Benefits	6

  

    

    

    

 

THIS SECOND
SUPPLEMENTAL INDENTURE (this “Second Supplemental Indenture”), dated as of December 1, 2016, is among SHIRE
ACQUISITIONS INVESTMENTS IRELAND DAC, an Irish designated activity company (the “Company”), as Issuer, SHIRE
PLC, a Jersey public limited company and parent of the Company (“Shire”), as Guarantor, BAXALTA INCORPORATED,
a Delaware corporation and wholly-owned subsidiary of Shire (“Baxalta”), as Subsidiary Guarantor, and DEUTSCHE
BANK TRUST COMPANY AMERICAS (the “Trustee”), as Trustee.

 

R E C I T
A L S

 

WHEREAS,
the Company has heretofore executed and delivered to the Trustee an Indenture, dated as of September 23, 2016, among the Company,
Shire and the Trustee (the “Base Indenture”), for the issuance from time to time of series of Securities of
the Company (“Securities”), as supplemented by a supplemental indenture thereto, dated as of September 23,
2016, among the Company, Shire and the Trustee (the “First Supplemental Indenture”), providing for the establishment
of four series of Securities pursuant to Section 2.02 of the Base Indenture, known as the (i) 1.900% Senior Notes due 2019 (the
“2019 Notes”), (ii) 2.400% Senior Notes due 2021 (the “2021 Notes”), (iii) 2.875% Senior
Notes due 2023 (the “2023 Notes”) and (iv) the 3.200% Senior Notes due 2026 (the “2026 Notes”
and, together with the 2019 Notes, the 2021 Notes and the 2023 Notes, the “Notes”), the form, substance, terms,
provisions and conditions of which were set forth in the Base Indenture and the First Supplemental Indenture (the Base Indenture,
as amended, supplemented and modified by the First Supplemental Indenture or otherwise from time to time, shall be referred to
herein as the “Indenture”);

 

WHEREAS,
Section 10.01(j) of the Base Indenture provides for the Company, Shire and the Trustee from time to time and at any time, without
the consent of the holders of the Securities of any series, to enter into an indenture or indentures supplemental to the Base
Indenture to add guarantees with respect to the Securities of any series or to secure the Securities of any series;

 

WHEREAS,
Section 6.01 of the First Supplemental Indenture provides that, if Baxalta becomes a guarantor of any Credit Facility (as defined
therein), then within 10 Business Days (as defined therein) of such event, the Company shall cause Baxalta to enter into a supplemental
indenture to the Base Indenture pursuant to which Baxalta shall agree to fully and unconditionally guarantee on a direct, unsecured
basis the due and punctual payment of the principal of, and any premium and interest on, the Notes and all other amounts, if any,
under the Indenture in respect of the Notes when and as such principal, premium, if any, interest and other amounts, if any, become
due and payable, whether at maturity or otherwise;

 

WHEREAS,
pursuant to Section 6.01 of the First Supplemental Indenture, Baxalta has agreed to execute and deliver to the Trustee this Second
Supplemental Indenture pursuant to which Baxalta shall fully and unconditionally guarantee on a direct, unsecured basis the due
and punctual payment of the principal of, and any premium and interest on, the Notes and all other amounts, if any, under the
Indenture in respect of the Notes when and as such principal, premium, if any, interest and other amounts, if any, become due
and payable, whether at maturity or otherwise on the terms and conditions set forth herein and in the Indenture;

 

    

    

    

 

WHEREAS,
the Company has furnished the Trustee with an Officers’ Certificate and an Opinion of Counsel, provided for under Sections
10.05 and 15.07 of the Base Indenture, stating that the execution of this Second Supplemental Indenture complies with the requirements
of the Indenture, is authorized or permitted by the Indenture, and that this Second Supplemental Indenture constitutes a legal,
valid and binding obligation of the Company, Shire and Baxalta, subject to certain customary exceptions stated therein, and that
all conditions precedent to the execution and delivery of this Second Supplemental Indenture have been complied with;

 

NOW, THEREFORE,
in consideration of the covenants and agreements set forth herein and for other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows:

 

Article
1

Definitions

 

Section 1.01.     
Relation to Indenture. This Second Supplemental Indenture constitutes an integral part of the Indenture.

 

Section 1.02.     
Definition of Terms. For all purposes of this Second Supplemental Indenture:

 

(a)            
Capitalized terms used herein without definition shall have the meanings set forth in the Base Indenture or the First Supplemental
Indenture, as applicable;

 

(b)            
a term defined anywhere in this Second Supplemental Indenture has the same meaning throughout;

 

(c)            
the singular includes the plural and vice versa;

 

(d)            
headings are for convenience of reference only and do not affect interpretation;

 

(e)            
the following terms have the meanings given to them in this ‎‎Section 1.02(e):

 

“Baxalta
Guarantee” shall have the meaning set forth in Section 2.01.

 

“Baxalta
Guaranteed Obligations” shall have the meaning set forth in Section 2.01.

 

“Subsidiary
Guarantor” shall mean, with respect to the Notes of any series, Baxalta and any legal successor thereto.

 

The terms
“Base Indenture,” “Baxalta,” “Company,” “First Supplemental
Indenture,” “Indenture,” “Notes,” “Second Supplemental Indenture,”
“Securities,” “Shire,” “Trustee,” “2019 Notes,” “2021
Notes,” “2023 Notes” and “2026 Notes” shall have the respective meanings set forth
in the recitals to this Second Supplemental Indenture and the paragraph preceding such recitals.

 

    2

    

    

 

Article
2

Baxalta Guarantee

 

Section 2.01.     
Baxalta Guarantee. Pursuant to the provisions of Section 6.01 of the First Supplemental Indenture, Baxalta, as primary
obligor and not merely as surety, hereby fully and unconditionally guarantees on a direct, unsecured basis to each holder of the
Notes of each series and to the Trustee, the Agents and their respective successors and assigns the due and punctual payment of
the principal of, and any premium and interest on, the Notes and all other amounts, if any, under the Indenture in respect of
the Notes when and as such principal, premium, if any, interest and other amounts, if any, become due and payable, whether at
maturity or otherwise (all such obligations hereinafter collectively called the “Baxalta Guaranteed Obligations”)
(such guarantee, the “Baxalta Guarantee”).

 

Baxalta waives
all set-offs and counterclaims, notice of acceptance of the Baxalta Guarantee, diligence, presentment, demand of payment, filing
of claims with a court in the event of merger or insolvency or bankruptcy of the Company, any right to require a proceeding filed
first against the Company, protest or notice with respect to the Notes or the indebtedness evidenced thereby and all demands whatsoever.

 

The obligations
of Baxalta hereunder shall not be affected by (a) the failure of any Noteholder, the Trustee or Agents to assert any claim
or demand or to enforce any right or remedy against the Company, any other guarantor or any other Person under the Indenture,
the Notes of any series or any other agreement or otherwise; (b) any extension or renewal of any obligation of the Company
under the Indenture or any Note, by operation of law or otherwise; (c) any rescission, waiver, amendment or modification
of any of the terms or provisions of the Indenture, the Notes of any series or any other agreement; or (d) any lack of validity
or enforceability of the Indenture, the Notes or any other agreement or instrument relating thereto.

 

Baxalta further
agrees that its Baxalta Guarantee herein constitutes a guarantee of payment when due (and not a guarantee of collection) and waives
any right to require that any resort be had by any Noteholder, the Trustee or Agents to any security held for payment of the Baxalta
Guaranteed Obligations.

 

Baxalta also
agrees to pay any and all costs and expenses (including reasonable attorneys’ fees) incurred by the Trustee, the Agents
or any Noteholder in enforcing any rights under this Article 2.

 

Section 2.02.     
Subrogation; Ranking.

 

(a)            
Baxalta shall be subrogated to all rights of the Trustee or the holders of any Notes against the Company in respect of
any amounts paid to the Trustee or such holder by Baxalta pursuant to the provisions of the Baxalta Guarantee; provided,
however, that Baxalta waives any right to enforce, or to receive any payments arising out of, or based upon, such right
of subrogation until all Baxalta Guaranteed Obligations shall have been paid in full.

 

(b)            
Baxalta covenants and agrees that its obligation to make payments of the Baxalta Guaranteed Obligations hereunder constitutes
a direct, unsecured obligation of Baxalta ranking

 

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equally in right of payment with all existing and future unsecured and unsubordinated
obligations of Baxalta and senior in right of payment to all future obligations of Baxalta that are expressly subordinated to
the Baxalta Guaranteed Obligations.

 

Section 2.03.     
Limitation on Liability. Baxalta, and by its acceptance of the Baxalta Guarantee, each holder of Notes of each such
series, hereby confirms that it is the intention of all such parties that the Baxalta Guarantee (a) does not constitute a
fraudulent transfer or conveyance for purposes of any Federal, state or foreign bankruptcy, insolvency, receivership or similar
law now or hereafter in effect, the Uniform Fraudulent Conveyance Act, the Uniform Fraudulent Transfer Act or any similar foreign,
federal or state law to the extent applicable to the Baxalta Guarantee, and (b) does not result in a distribution to Noteholders
not permitted under the applicable foreign or state law. Any term or provision of the Indenture to the contrary notwithstanding,
the maximum aggregate amount of the obligations guaranteed hereunder by Baxalta shall not exceed the maximum amount that can be
hereby guaranteed without rendering the Baxalta Guarantee voidable under applicable law relating to fraudulent conveyance or fraudulent
transfer or similar laws affecting the rights of creditors generally.

 

Section 2.04.     
Successors and Assigns. Subject to Section 2.06 hereof, this Article 2 shall be binding upon Baxalta and its successors
and assigns and shall inure to the benefit of the successors and assigns of the Trustee, the Agents and the Noteholders and, in
the event of any transfer or assignment of rights by any Noteholders, the Trustee or the Agents, the rights and privileges conferred
upon that party in the Indenture and in the Notes of the relevant series shall automatically extend to and be vested in such transferee
or assignee, all subject to the terms and conditions of the Indenture.

 

Section 2.05.     
No Waiver. Neither a failure nor a delay on the part of either the Trustee, the Agents or the Noteholders in exercising
any right, power or privilege under this Article 2 shall operate as a waiver thereof, nor shall a single or partial exercise thereof
preclude any other or further exercise of any right, power or privilege. The rights, remedies and benefits of the Trustee, the
Agents and the Noteholders herein expressly specified are cumulative and not exclusive of any other rights, remedies or benefits
which either may have under this Article 2 at law, in equity, by statute or otherwise.

 

Section 2.06.     
Release of Baxalta Guarantee. The Baxalta Guarantee shall be automatically released with respect to a series of
Notes and the Indenture with respect to such series of Notes:

 

(a)            
upon the release or termination of Baxalta’s guarantee with respect to all Credit Facilities such that, after such
release or termination, Baxalta is no longer a guarantor of any Credit Facility;

 

(b)            
upon (i) the sale or other disposition (including by way of consolidation, merger, dissolution or otherwise) of the capital
stock of Baxalta such that it is no longer a Subsidiary of Shire or (ii) the sale or other disposition of all or substantially
all of the assets of Baxalta, in either such case in accordance with the terms of the Indenture;

 

    4

    

    

 

(c)            
if the Company exercises its defeasance option with respect to such series of Notes pursuant to Sections 12.02 or 12.03
of the Base Indenture or if the Company’s obligations under the Indenture with respect to such series of Notes are satisfied
and discharged in accordance with the terms of the Indenture; or

 

(d)            
otherwise upon payment in full of the Baxalta Guaranteed Obligations with respect to such series of Notes.

 

Section 2.07.     
Modification of Indenture. Notwithstanding anything to the contrary in the Indenture, the Company, Shire and Baxalta,
together with the Trustee, may by supplemental indenture modify the terms of, or terminate, the Baxalta Guarantee with respect
to one or more series of Notes with the consent of the holders of at least a majority in aggregate principal amount of the outstanding
debt securities of all series issued under the Indenture, including such series of Notes, affected by such modification or termination,
voting as a single class. Notwithstanding the foregoing, holders of the Notes of any series shall vote as a separate class with
respect to a modification or termination of the Baxalta Guarantee that affects only the Notes of such series, and the holders
of other series of debt securities issued under the Indenture shall not have any voting rights with respect to such matters as
they relate to the Notes of such series.

 

Article
3

Miscellaneous

 

Section 3.01.     
Ratification of Indenture. The Base Indenture, as supplemented by the First Supplemental Indenture and this Second
Supplemental Indenture, is in all respects ratified and confirmed, and this Second Supplemental Indenture shall be deemed part
of the Base Indenture, as supplemented by the First Supplemental Indenture, in the manner and to the extent herein and therein
provided.

 

Section 3.02.     
Transfer of Interest. Subject to Section 2.06 hereof, the Baxalta Guarantee shall be binding upon Baxalta and its
successors and assigns, and shall inure to the benefit of and be enforceable by any Holder of Notes, the Trustee, and by their
respective successors, transferees and assigns, pursuant to the terms hereof. The Baxalta Guarantee shall not be deemed to create
any right in, or to be in whole or in part for the benefit of, any other person.

 

Section 3.03.     
Notices, Etc., to Baxalta. Any request, demand, authorization, direction, notice, consent, waiver or other action
of Holders or other document provided or permitted by the Indenture to be made upon, given or furnished to, or filed with, Baxalta
by the Trustee or by any Holder shall be sufficient for every purpose hereunder (unless otherwise herein expressly provided) if
in writing and mailed, first-class postage prepaid, or by any courier guaranteeing overnight delivery, to Baxalta addressed to
the address last furnished in writing to the Trustee by Baxalta, or, if no such address has been furnished, to Attn: William R.
Mordan, General Counsel, Shire plc, 5 Riverwalk, Citywest Business Campus, Dublin 24, Republic of Ireland. All requests and other
communications shall be deemed to have been duly given three business days after being deposited in the mail if mailed postage
prepaid; and on the next business day if timely delivered to an air courier guaranteeing overnight delivery.

 

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Section 3.04.     
No Recourse Against Others. A director, officer, employee, stockholder, partner or other owner of Baxalta, as such,
shall not have any liability for any obligations of Baxalta under this Second Supplemental Indenture, including the Baxalta Guarantee,
or for any claim based on, in respect of or by reason of such obligations or their creation.

 

Section 3.05.     
Trustee Not Responsible for Recitals. The recitals herein contained are made by the Company, Shire or Baxalta, as
applicable, and not by the Trustee, and the Trustee assumes no responsibility for the correctness thereof. The Trustee makes no
representation as to the validity or sufficiency of this Second Supplemental Indenture.

 

Section 3.06.     
Governing Law. THIS SECOND SUPPLEMENTAL INDENTURE AND EACH NOTE, AND ANY CLAIM, CONTROVERSY OR DISPUTE ARISING UNDER
OR RELATED TO THIS SECOND SUPPLEMENTAL INDENTURE OR ANY NOTE, SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF
THE STATE OF NEW YORK.

 

Section 3.07.     
Waiver of Trial by Jury. EACH OF THE COMPANY, BAXALTA, THE TRUSTEE, SHIRE AND EACH HOLDER OF NOTES, BY ITS ACCEPTANCE
THEREOF, HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY
LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS INDENTURE, THE NOTES OR THE TRANSACTIONS CONTEMPLATED HEREBY.

 

Section 3.08.     
Table of Contents, Headings, etc. The table of contents and the titles and headings of the articles and sections
of this Second Supplemental Indenture have been inserted for convenience of reference only, are not to be considered a part hereof,
and shall in no way modify or restrict any of the terms or provisions hereof.

 

Section 3.09.     
Execution in Counterparts. This Second Supplemental Indenture may be executed in any number of counterparts, each
of which shall be an original, but such counterparts shall together constitute but one and the same instrument. Signatures delivered
by facsimile or in portable document format (.pdf) by email shall be deemed to be originals for all purposes hereunder.

 

Section 3.10.     
Separability; Benefits. In case any one or more of the provisions contained in this Second Supplemental Indenture
or in the Notes shall for any reason be held to be invalid, illegal or unenforceable, in any respect, then, to the extent permitted
by law, such invalidity, illegality or unenforceability of the remaining provisions shall not in any way be affected or impaired
thereby. Nothing in this Second Supplemental Indenture or in the Notes, expressed or implied, shall give to any person, other
than the parties hereto and their successors hereunder, and the holders of the Notes, any benefit or any legal or equitable right,
remedy or claim under this Second Supplemental Indenture.

 

[Signature
Page Follows]

 

    6

    

    

 

IN WITNESS
WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed, as of the day and year first written
above.

 

	 	GIVEN under the common seal of SHIRE ACQUISITIONS INVESTMENTS IRELAND
    DAC and DELIVERED as a DEED:
	 	 
	 	 	/s/ Michael Garry
	 	 	Name:Michael Garry
	 	 	Title:Director
	 	 	 
	 	 	/s/ Vincent Dunne

	 	 	Name:Vincent Dunne
	 	 	Title:Director
	 	 	 
	 	SHIRE
PLC, as Guarantor

	 	 
	 	 
	 	By:	 /s/ Jeffrey Poulton

	 	 	Name:Jeffrey Poulton
	 	 	Title:Chief Financial Officer
	 	 	 
	 	 	 
	 	BAXALTA
INCORPORATED, as Subsidiary Guarantor

	 	 
	 	 
	 	By:	 /s/ John Miller
	 	 	Name:John Miller
	 	 	Title:Director

 

  

    
[Signature page to Second Supplemental Indenture]

    

    

 

IN WITNESS
WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed, as of the day and year first written
above.

 

	 	DEUTSCHE
BANK TRUST COMPANY AMERICAS, not in its individual capacity but solely as Trustee, Security Registrar and Paying Agent

	 	 
	 	 
	 	By:   Deutsche Bank National Trust Company
	 	 
	 	By:	/s/ Chris Niesz
	 	 	Name:Chris Niesz

	 	 	Title:Assistant Vice President
	 	 	 
	 	 	 
	 	By:	/s/ Irina Golovashchuk
	 	 	Name:Irina Golovashchuk
	 	 	Title:Vice President

 

    
[Signature page to Second Supplemental Indenture]EX-10.1

 Exhibit 10.1 

MYRIAD GENETICS, INC. 

2010 EMPLOYEE, DIRECTOR AND CONSULTANT EQUITY INCENTIVE PLAN, AS AMENDED 

(as amended on December 1, 2016) 
  

	1.	DEFINITIONS. 

 Unless otherwise specified or unless the context otherwise requires, the
following terms, as used in this Myriad Genetics, Inc. 2010 Employee, Director and Consultant Equity Incentive Plan, as amended, have the following meanings: 

Administrator means the Board of Directors, unless it has delegated power to act on its behalf to the Committee, in which case the
Administrator means the Committee. 
 Affiliate means a corporation which, for purposes of Section 424 of the Code, is a parent or
subsidiary of the Company, direct or indirect. 
 Agreement means an agreement between the Company and a Participant delivered
pursuant to the Plan and pertaining to a Stock Right, in such form as the Administrator shall approve. 
 Board of Directors means the
Board of Directors of the Company. 
 Cause means, with respect to a Participant (a) dishonesty with respect to the Company or any
Affiliate, (b) insubordination, substantial malfeasance or non-feasance of duty, (c) unauthorized disclosure of confidential information, (d) breach by a Participant of any provision of any employment,
consulting, advisory, nondisclosure, non-competition or similar agreement between the Participant and the Company or any Affiliate, and (e) conduct substantially prejudicial to the business of the Company or any Affiliate; provided, however, that
any provision in an agreement between a Participant and the Company or an Affiliate, which contains a conflicting definition of Cause for termination and which is in effect at the time of such termination, shall supersede this definition with
respect to that Participant. The determination of the Administrator as to the existence of Cause will be conclusive on the Participant and the Company. 

Change of Control means the occurrence of any of the following events: 

 

	 	(i)	Ownership. Any “Person” (as such term is used in Sections 13(d) and 14(d) of the Exchange Act) becomes the “Beneficial Owner” (as defined in Rule 13d-3 under the Exchange Act), directly
or indirectly, of securities of the Company representing 50% or more of the total voting power represented by the Company’s then outstanding voting securities (excluding for this purpose any such voting securities held by the Company or its
Affiliates or by any employee benefit plan of the Company) pursuant to a transaction or a series of related transactions which the Board of Directors does not approve; or 

  
 1 

	 	(ii)	Merger/Sale of Assets. (A) A merger or consolidation of the Company whether or not approved by the Board of Directors, other than a merger or consolidation which would result in the voting securities of the
Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity or the parent of such corporation) more than 50% of the total voting power
represented by the voting securities of the Company or such surviving entity or parent of such corporation, as the case may be, outstanding immediately after such merger or consolidation; or (B) the sale or disposition by the Company of all or
substantially all of the Company’s assets in a transaction requiring stockholder approval; or 

  

	 	(iii)	“Change of Control” shall be interpreted, if applicable, in a manner, and limited to the extent necessary, so that it will not cause adverse tax consequences under Section 409A. 

Code means the United States Internal Revenue Code of 1986, as amended including any successor statute, regulation and guidance thereto.

 Committee means the committee of the Board of Directors to which the Board of Directors has delegated power to act under or
pursuant to the provisions of the Plan. 
 Common Stock means shares of the Company’s common stock, $.01 par value per share.

 Company means Myriad Genetics, Inc., a Delaware corporation. 

Consultant means any natural person who is an advisor or consultant that provides bona fide services to the Company or its Affiliates,
provided that such services are not in connection with the offer or sale of securities in a capital raising transaction, and do not directly or indirectly promote or maintain a market for the Company’s or its Affiliates’ securities. 

Disability or Disabled means permanent and total disability as defined in Section 22(e)(3) of the Code. 

Employee means any employee of the Company or of an Affiliate (including, without limitation, an employee who is also serving as an
officer or director of the Company or of an Affiliate), designated by the Administrator to be eligible to be granted one or more Stock Rights under the Plan. 

Exchange Act means the Securities Exchange Act of 1934, as amended. 

  
 2 

 Fair Market Value of a Share of Common Stock means: 

(1)        If the Common Stock is listed on a national securities exchange or traded in
the over-the-counter market and sales prices are regularly reported for the Common Stock, the closing or, if not applicable, the last price of the Common Stock on the
composite tape or other comparable reporting system for the trading day on the applicable date and if such applicable date is not a trading day, the last market trading day prior to such date; 

(2)        If the Common Stock is not traded on a national securities exchange but is
traded on the over-the-counter market, if sales prices are not regularly reported for the Common Stock for the trading day referred to in clause (1), and if bid and
asked prices for the Common Stock are regularly reported, the mean between the bid and the asked price for the Common Stock at the close of trading in the over-the-counter market for the trading day on which Common Stock was traded on the applicable
date and if such applicable date is not a trading day, the last market trading day prior to such date; and 

(3)        If the Common Stock is neither listed on a national securities exchange nor
traded in the over-the-counter market, such value as the Administrator, in good faith, shall determine. 

ISO means an option intended to qualify as an incentive stock option under Section 422 of the Code. 

Non-Qualified Option means an option which is not intended to qualify as an ISO.

 Option means an ISO or Non-Qualified Option granted under the Plan. 

Participant means an Employee, director or Consultant of the Company or an Affiliate to whom one or more Stock Rights are granted under
the Plan. As used herein, “Participant” shall include “Participant’s Survivors” where the context requires. 

Plan means this Myriad Genetics, Inc. 2010 Employee, Director and Consultant Equity Incentive Plan, as amended. 

Securities Act means the Securities Act of 1933, as amended. 

Shares means shares of the Common Stock as to which Stock Rights have been or may be granted under the Plan or any shares of capital
stock into which the Shares are changed or for which they are exchanged within the provisions of Paragraph 3 of the Plan. The Shares issued under the Plan may be authorized and unissued shares or shares held by the Company in its treasury,
or both. 
 Stock Appreciation Right means a Stock-Based Award providing for the right to receive an amount equal to the excess of the
Fair Market Value of the Shares on the date of exercise over the exercise price of the Stock Appreciation Right, which exercise price shall not be less than the Fair Market Value of the Shares on the date of grant and a term of not more than ten
years provided that such term shall be no more than eight years for each Stock Appreciation Right granted on or after December 5, 2012. 

  
 3 

 Stock-Based Award means a grant by the Company under the Plan of an equity award or an
equity based award which is not an Option or a Stock Grant. 
 Stock Grant means a grant by the Company of Shares under the Plan. 

Stock Right means a right to Shares or the value of Shares of the Company granted pursuant to the Plan — an ISO, a Non-Qualified
Option, a Stock Grant or a Stock-Based Award. 
 Survivor means a deceased Participant’s legal representatives and/or any person
or persons who acquired the Participant’s rights to a Stock Right by will or by the laws of descent and distribution. 
  

	2.	PURPOSES OF THE PLAN. 

 The Plan is intended to encourage ownership of Shares by
Employees and directors of and certain Consultants to the Company and its Affiliates in order to attract and retain such people, to induce them to work for the benefit of the Company or of an Affiliate and to provide additional incentive for them to
promote the success of the Company or of an Affiliate. The Plan provides for the granting of ISOs, Non-Qualified Options, Stock Grants and Stock-Based Awards. 

 

	3.	SHARES SUBJECT TO THE PLAN. 

 (a) Commencing on December 1, 2016, the additional number
of Shares which may be issued from time to time pursuant to this Plan shall not exceed (i) 2,830,6901 shares of Common Stock plus (ii) any shares of Common Stock that are represented by options
previously granted under the Company’s 2003 Employee, Director and Consultant Stock Option Plan, as amended, that expire or are cancelled without delivery of shares of Common Stock, or the equivalent of such number of Shares after the
Administrator, in its sole discretion, has interpreted the effect of any stock split, stock dividend, combination, recapitalization or similar transaction in accordance with Paragraph 24 of this Plan; provided, however, that as of December 1, 2016
no more than 2,432,2912 Shares shall be added to the Plan pursuant to subsection (ii). 

(b) The grant of any Stock Right other than an Option or a Stock Appreciation Right shall for purposes of Paragraph 3(a), reduce the
number of Shares available for issuance under this Plan by 2 Shares for each such Share actually subject to the Stock Right and shall be deemed for purposes of this Paragraph 3, as a Stock Right of 2 Shares for each such Share actually subject to
the Stock Right. The grant of an Option or a Stock Appreciation Right shall be deemed for purposes of this Paragraph 3, as a Stock Right for one Share for each such Share actually subject to the Stock Right.

 
  

	1 	Balance consists of 330,690 remaining shares available for issuance under the Plan as of October 5, 2016 and 2,500,000 additional shares approved by the stockholders at the Annual Meeting of Stockholders held on
December 1, 2016. 

	2 	This number consists of options to purchase 2,432,291 shares of common stock that are outstanding under the 2003 Plan as of October 5, 2016. 

  
 4 

 (c) If an Option ceases to be “outstanding”, in whole or in part (other than by
exercise), or if the Company shall reacquire (at not more than its original issuance price) any Shares issued pursuant to a Stock Grant or Stock-Based Award, or if any Stock Right expires or is forfeited, cancelled, or otherwise terminated or
results in any Shares not being issued, the unissued or reacquired Shares which were subject to such Stock Right shall again be available for issuance from time to time pursuant to this Plan and in accordance with the provisions of Paragraph 3(b)
above.3 Notwithstanding the foregoing, if a Stock Right is exercised, in whole or in part, by tender of Shares or if the Company or an Affiliate’s tax withholding obligation is satisfied by
withholding Shares, the number of Shares deemed to have been issued under the Plan for purposes of the limitation set forth in Paragraph 3(a) above shall be the number of Shares that were subject to the Stock Right or portion thereof, and not the
net number of Shares actually issued and any Stock Appreciation Right to be settled in shares of Common Stock shall be counted in full against the number of Shares available for issuance under the Plan, regardless of the number of exercise gain
Shares issued upon the settlement of the Stock Appreciation Right. However, in the case of ISOs, the foregoing provisions shall be subject to any limitations under the Code. 
  

	4.	ADMINISTRATION OF THE PLAN. 

 The Administrator of the Plan will be the Board of
Directors, except to the extent the Board of Directors delegates its authority to the Committee, in which case the Committee shall be the Administrator. Subject to the provisions of the Plan, the Administrator is authorized to: 

(a)    Interpret the provisions of the Plan and all Stock Rights and to make all rules and determinations which it deems
necessary or advisable for the administration of the Plan; 
 (b)    Determine which Employees, directors and
Consultants shall be granted Stock Rights; 
 (c)    Determine the number of Shares for which a Stock Right or Stock
Rights shall be granted, provided, however, that in no event shall Stock Rights with respect to more than 1,000,000 Shares be granted to any Participant in any fiscal year; 

(d)    Specify the terms and conditions upon which a Stock Right or Stock Rights may be granted; 

(e)    Make changes to any outstanding Stock Right, including, without limitation, to reduce or increase the exercise
price or purchase price, accelerate the vesting schedule or extend the expiration date, provided that no such change shall impair the rights of a Participant under any grant previously made without such Participant’s consent and further
provided that without the prior approval of the Company’s shareholders, Options and Stock Appreciation Rights issued will not be repriced, replaced, or regranted through cancellation, or by lowering the exercise price of a previously granted
award, or repurchased for cash when the Fair Market Value is less than the exercise price; and 
  

 

	3 	As of October 5, 2016 options to purchase 5,657,550 shares of common stock and restricted stock units representing 2,047,537 shares of common stock are outstanding under the Plan. 

  
 5 

 (f)    Adopt any sub-plans applicable to residents of any specified
jurisdiction as it deems necessary or appropriate in order to comply with or take advantage of any tax or other laws applicable to the Company, any Affiliate or to Participants or to otherwise facilitate the administration of the Plan, which
sub-plans may include additional restrictions or conditions applicable to Stock Rights or Shares issuable pursuant to a Stock Right; 
 provided, however,
that all such interpretations, rules, determinations, terms and conditions shall be made and prescribed in the context of not causing any adverse tax consequences under Section 409A of the Code and preserving the tax status under Section 422 of the
Code of those Options which are designated as ISOs. Subject to the foregoing, the interpretation and construction by the Administrator of any provisions of the Plan or of any Stock Right granted under it shall be final, unless otherwise
determined by the Board of Directors, if the Administrator is the Committee. In addition, if the Administrator is the Committee, the Board of Directors may take any action under the Plan that would otherwise be the responsibility of the
Committee. 
 To the extent permitted under applicable law, the Board of Directors or the Committee may allocate all or any portion of its
responsibilities and powers to any one or more of its members and may delegate all or any portion of its responsibilities and powers to any other person selected by it. The Board of Directors or the Committee may revoke any such allocation or
delegation at any time. Notwithstanding the foregoing, only the Board of Directors or the Committee shall be authorized to grant a Stock Right to any director of the Company or to any “officer” of the Company (as defined by Rule 16a-1
under the Exchange Act). 
  

	5.	ELIGIBILITY FOR PARTICIPATION. 

 The Administrator will, in its sole discretion, name the
Participants in the Plan; provided, however, that each Participant must be an Employee, director or Consultant of the Company or of an Affiliate at the time a Stock Right is granted. Notwithstanding the foregoing, the Administrator may
authorize the grant of a Stock Right to a person not then an Employee, director or Consultant of the Company or of an Affiliate; provided, however, that the actual grant of such Stock Right shall be conditioned upon such person becoming eligible to
become a Participant at or prior to the time of the execution of the Agreement evidencing such Stock Right. ISOs may be granted only to Employees who are deemed to be residents of the United States for tax
purposes. Non-Qualified Options, Stock Grants and Stock-Based Awards may be granted to any Employee, director or Consultant of the Company or an Affiliate. The granting of any Stock Right to any
individual shall neither entitle that individual to, nor disqualify him or her from, participation in any other grant of Stock Rights or any grant under any other benefit plan established by the Company or any Affiliate for Employees, directors or
Consultants. 
  

	6.	TERMS AND CONDITIONS OF OPTIONS. 

 Each Option shall be set forth in writing in an Option
Agreement, duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Administrator may provide that Options be granted subject to such terms and conditions, consistent

  
 6 

 
with the terms and conditions specifically required under this Plan, as the Administrator may deem appropriate including, without limitation, subsequent approval by the shareholders of the
Company of this Plan or any amendments thereto. The Option Agreements shall be subject to at least the following terms and conditions: 

(a)    Non-Qualified Options: Each Option intended to be
a Non-Qualified Option shall be subject to the terms and conditions which the Administrator determines to be appropriate and in the best interest of the Company, subject to the following minimum standards for
any such Non-Qualified Option: 
  

	 	(i)	Exercise Price: Each Option Agreement shall state the exercise price (per share) of the Shares covered by each Option, which exercise price shall be determined by the Administrator and shall be at least equal to
the Fair Market Value per share of the Common Stock on the date of grant of the Option. 

  

	 	(ii)	Number of Shares: Each Option Agreement shall state the number of Shares to which it pertains. 

  

	 	(iii)	Option Periods: Each Option Agreement shall state the date or dates on which it first is exercisable and the date after which it may no longer be exercised, provided that each Non-Qualified Option shall
terminate not more than ten years from the date of grant provided that such term shall be no more than eight years from the date of grant for each Non-Qualified Option granted on or after December 5, 2012. Each Option Agreement may provide that
the Option rights accrue or become exercisable in installments over a period of months or years, or upon the occurrence of certain conditions or the attainment of stated goals or events.

 

	 	(iv)	Option Conditions: Exercise of any Option may be conditioned upon the Participant’s execution of a Share purchase agreement in form satisfactory to the Administrator providing for certain protections
for the Company and its other shareholders, including requirements that: 

  

	 	A.	The Participant’s or the Participant’s Survivors’ right to sell or transfer the Shares may be restricted; and 

  

	 	B.	The Participant or the Participant’s Survivors may be required to execute letters of investment intent and must also acknowledge that the Shares will bear legends noting any applicable restrictions.

 (b)     ISOs: Each Option intended to be an ISO shall be issued only to an Employee who is
deemed to be a resident of the United States for tax purposes, and shall be subject to the following terms and conditions, with such additional restrictions or changes as the Administrator determines are appropriate but not in conflict with Section
422 of the Code and relevant regulations and rulings of the Internal Revenue Service: 
  

	 	(i)	Minimum standards: The ISO shall meet the minimum standards required of Non-Qualified Options, as described in Paragraph 6(a) above, except for clause (i) thereunder.

  
 7 

	 	(ii)	Exercise Price: Immediately before the ISO is granted, if the Participant owns, directly or by reason of the applicable attribution rules in Section 424(d) of the Code: 

 

	 	A.	10% or less of the total combined voting power of all classes of stock of the Company or an Affiliate, the exercise price per share of the Shares covered by each ISO shall not be less than 100% of the Fair Market
Value per share of the Common Stock on the date of grant of the Option; or 

  

	 	B.	More than 10% of the total combined voting power of all classes of stock of the Company or an Affiliate, the exercise price per share of the Shares covered by each ISO shall not be less than 110% of the Fair Market
Value per share of the Common Stock on the date of grant of the Option. 

  

	 	(iii)	Term of Option: For Participants who own: 

  

	 	A.	10% or less of the total combined voting power of all classes of stock of the Company or an Affiliate, each ISO shall terminate not more than ten years from the date of the grant or at such earlier time as the
Option Agreement may provide provided that such term shall be no more than eight years from the date of grant for each ISO granted on or after December 5, 2012; or 

 

	 	B.	More than 10% of the total combined voting power of all classes of stock of the Company or an Affiliate, each ISO shall terminate not more than five years from the date of the grant or at such earlier time as the Option
Agreement may provide. 

  

	 	(iv)	Limitation on Yearly Exercise: The Option Agreements shall restrict the amount of ISOs which may become exercisable in any calendar year (under this or any other ISO plan of the Company or an Affiliate) so
that the aggregate Fair Market Value (determined on the date each ISO is granted) of the stock with respect to which ISOs are exercisable for the first time by the Participant in any calendar year does not exceed $100,000. 

 

	7.	TERMS AND CONDITIONS OF STOCK GRANTS. 

 Each Stock Grant to a Participant shall state the
principal terms in an Agreement duly executed by the Company and, to the extent required by law or requested by the Company, by the Participant. The Agreement shall be in a form approved by the Administrator and shall contain terms and
conditions which the Administrator determines to be appropriate and in the best interest of the Company, subject to the following minimum standards: 

(a)    Each Agreement shall state the purchase price per share, if any, of the Shares covered by each Stock Grant, which
purchase price shall be determined by the Administrator but shall not be less than the minimum consideration required by the Delaware General Corporation Law, if any, on the date of grant of the Stock Grant; 

  
 8 

 (b)    Each Agreement shall state the number of Shares to which the Stock
Grant pertains; and 
 (c)    Each Agreement shall include the terms of any right of the Company to restrict or
reacquire the Shares subject to the Stock Grant, including the time and events upon which such rights shall accrue and the purchase price therefor, if any. 
  

	8.	TERMS AND CONDITIONS OF OTHER STOCK-BASED AWARDS.  

 The Administrator shall have the
right to grant other Stock-Based Awards based upon the Common Stock having such terms and conditions as the Administrator may determine, including, without limitation, the grant of Shares based upon certain conditions, the grant of securities
convertible into Shares and the grant of Stock Appreciation Rights, phantom stock awards or stock units. The principal terms of each Stock-Based Award shall be set forth in an Agreement, duly executed by the Company and, to the extent required
by law or requested by the Company, by the Participant. The Agreement shall be in a form approved by the Administrator and shall contain terms and conditions which the Administrator determines to be appropriate and in the best interest of the
Company. 
 The Company intends that the Plan and any Stock-Based Awards granted hereunder be exempt from the application of Section 409A of
the Code or meet the requirements of paragraphs (2), (3) and (4) of subsection (a) of Section 409A of the Code, to the extent applicable, and be operated in accordance with Section 409A so that any compensation deferred under any Stock-Based Award
(and applicable investment earnings) shall not be included in income under Section 409A of the Code. Any ambiguities in the Plan shall be construed to effect the intent as described in this Paragraph 8. 

 

	9.	EXERCISE OF OPTIONS AND ISSUE OF SHARES. 

 An Option (or any part or installment thereof)
shall be exercised by giving written notice to the Company or its designee (in a form acceptable to the Administrator, which may include electronic notice), together with provision for payment of the aggregate exercise price in accordance with this
Paragraph for the Shares as to which the Option is being exercised, and upon compliance with any other condition(s) set forth in the Option Agreement. Such notice shall be signed by the person exercising the Option (which signature may be
provided electronically in a form acceptable to the Administrator), shall state the number of Shares with respect to which the Option is being exercised and shall contain any representation required by the Plan or the Option Agreement. Payment
of the exercise price for the Shares as to which such Option is being exercised shall be made (a) in United States dollars in cash or by check, or (b) at the discretion of the Administrator, through delivery of shares of Common Stock held
for at least six months (if required to avoid negative accounting treatment) having a Fair Market Value equal as of the date of the exercise to the aggregate cash exercise price for the number of Shares as to which the Option is being

  
 9 

 
exercised, or (c) at the discretion of the Administrator, by having the Company retain from the Shares otherwise issuable upon exercise of the Option, a number of Shares having a Fair Market
Value equal as of the date of exercise to the aggregate exercise price for the number of Shares as to which the Option is being exercised, or (d) at the discretion of the Administrator, in accordance with a cashless exercise program established with
a securities brokerage firm, and approved by the Administrator, or (e) at the discretion of the Administrator, by any combination of (a), (b), (c) and (d) above or (f) at the discretion of the Administrator, by payment of such other lawful
consideration as the Administrator may determine. Notwithstanding the foregoing, the Administrator shall accept only such payment on exercise of an ISO as is permitted by Section 422 of the Code. 

The Company shall then reasonably promptly deliver the Shares as to which such Option was exercised to the Participant (or to the
Participant’s Survivors, as the case may be). In determining what constitutes “reasonably promptly,” it is expressly understood that the issuance and delivery of the Shares may be delayed by the Company in order to comply with
any law or regulation (including, without limitation, state securities or “blue sky” laws) which requires the Company to take any action with respect to the Shares prior to their issuance. The Shares shall, upon delivery, be fully
paid, non-assessable Shares. 
 The Administrator shall have the right to accelerate the date of exercise of any installment of any Option;
provided that the Administrator shall not accelerate the exercise date of any installment of any Option granted to an Employee as an ISO (and not previously converted into a Non-Qualified Option pursuant to Paragraph 27) without the prior approval
of the Employee if such acceleration would violate the annual vesting limitation contained in Section 422(d) of the Code, as described in Paragraph 6(b)(iv). 

The Administrator may, in its discretion, amend any term or condition of an outstanding Option provided (i) such term or condition as amended
is permitted by the Plan, (ii) any such amendment shall be made only with the consent of the Participant to whom the Option was granted, or in the event of the death of the Participant, the Participant’s Survivors, if the amendment is adverse
to the Participant, and (iii) any such amendment of any Option shall be made only after the Administrator determines whether such amendment would constitute a “modification” of any Option which is an ISO (as that term is defined in Section
424(h) of the Code) or would cause any adverse tax consequences for the holder of any Option including, but not limited to, pursuant to Section 409A of the Code. 
  

	10.	ACCEPTANCE OF STOCK GRANTS AND STOCK-BASED AWARDS AND ISSUE OF SHARES. 

 A Stock Grant or
Stock-Based Award (or any part or installment thereof) shall be accepted by executing the applicable Agreement and delivering it to the Company or its designee, together with provision for payment of the purchase price, if any, in accordance with
this Paragraph for the Shares as to which such Stock Grant or Stock-Based Award is being accepted, and upon compliance with any other conditions set forth in the applicable Agreement. Payment of the purchase price for the Shares as to which
such Stock Grant or Stock-Based Award is being accepted shall be made (a) in United States dollars in cash or by check, or (b) at the discretion of the Administrator, through delivery of shares of Common Stock held for at least six months (if
required to avoid negative 

  
 10 

 
accounting treatment) and having a Fair Market Value equal as of the date of acceptance of the Stock Grant or Stock Based-Award to the purchase price of the Stock Grant or Stock-Based Award, or
(c) at the discretion of the Administrator, by any combination of (a) and (b) above; or (c) at the discretion of the Administrator, by payment of such other lawful consideration as the Administrator may determine. 

The Company shall then, if required by the applicable Agreement, reasonably promptly deliver the Shares as to which such Stock Grant or
Stock-Based Award was accepted to the Participant (or to the Participant’s Survivors, as the case may be), subject to any escrow provision set forth in the applicable Agreement. In determining what constitutes “reasonably
promptly,” it is expressly understood that the issuance and delivery of the Shares may be delayed by the Company in order to comply with any law or regulation (including, without limitation, state securities or “blue sky” laws) which
requires the Company to take any action with respect to the Shares prior to their issuance. 
 The Administrator may, in its discretion,
amend any term or condition of an outstanding Stock Grant, Stock-Based Award or applicable Agreement provided (i) such term or condition as amended is permitted by the Plan, (ii) any such amendment shall be made only with the consent of the
Participant to whom the Stock Grant or Stock-Based Award was made, if the amendment is adverse to the Participant, and (iii) any such amendment shall be made only after the Administrator determines whether such amendment would cause any adverse tax
consequences to the Participant, including, but not limited to, pursuant to Section 409A of the Code. 
  

	11.	RIGHTS AS A SHAREHOLDER. 

 No Participant to whom a Stock Right has been granted shall
have rights as a shareholder with respect to any Shares covered by such Stock Right, except after due exercise of the Option or acceptance of the Stock Grant or as set forth in any Agreement, and tender of the aggregate exercise or purchase price,
if any, for the Shares being purchased pursuant to such exercise or acceptance and registration of the Shares in the Company’s share register in the name of the Participant. 

 

	12.	ASSIGNABILITY AND TRANSFERABILITY OF STOCK RIGHTS. 

 By its terms, a Stock Right granted
to a Participant shall not be transferable by the Participant other than (i) by will or by the laws of descent and distribution, or (ii) as approved by the Administrator in its discretion and set forth in the applicable Agreement provided that no
Stock Right may be transferred by a Participant for value. Notwithstanding the foregoing, an ISO transferred except in compliance with clause (i) above shall no longer qualify as an ISO. The designation of a beneficiary of a Stock Right by
a Participant, with the prior approval of the Administrator and in such form as the Administrator shall prescribe, shall not be deemed a transfer prohibited by this Paragraph. Except as provided above, a Stock Right shall only be exercisable or
may only be accepted, during the Participant’s lifetime, by such Participant (or by his or her legal representative) and shall not be assigned, pledged or hypothecated in any way (whether by operation of law or otherwise) and shall not be
subject to execution, attachment or similar process. Any attempted transfer, assignment, pledge, hypothecation or other disposition of any Stock Right or of any rights granted thereunder contrary to the provisions of this Plan, or the levy of
any attachment or similar process upon a Stock Right, shall be null and void. 

  
 11 

	13.	EFFECT ON OPTIONS OF TERMINATION OF SERVICE OTHER THAN FOR CAUSE OR DEATH OR DISABILITY. 

Except as otherwise provided in a Participant’s Option Agreement, in the event of a termination of service (whether as an Employee,
director or Consultant) with the Company or an Affiliate before the Participant has exercised an Option, the following rules apply: 

(a)    A Participant who ceases to be an Employee, director or Consultant of the Company or of an Affiliate (for any
reason other than termination for Cause, Disability, or death for which events there are special rules in Paragraphs 14, 15, and 16, respectively), may exercise any Option granted to him or her to the extent that the Option is exercisable on the
date of such termination of service, but only within such term as the Administrator has designated in a Participant’s Option Agreement. 

(b)    Except as provided in Subparagraph (c) below, or Paragraph 15 or 16, in no event may an Option intended to be an
ISO, be exercised later than three months after the Participant’s termination of employment.
 (c)    The
provisions of this Paragraph, and not the provisions of Paragraph 15 or 16, shall apply to a Participant who subsequently becomes Disabled or dies after the termination of employment, director status or consultancy; provided, however, in the case of
a Participant’s Disability or death within three months after the termination of employment, director status or consultancy, the Participant or the Participant’s Survivors may exercise the Option within one year after the date of the
Participant’s termination of service, but in no event after the date of expiration of the term of the Option. 

(d)    Notwithstanding anything herein to the contrary, if subsequent to a Participant’s termination of employment,
termination of director status or termination of consultancy, but prior to the exercise of an Option, the Administrator determines that, either prior or subsequent to the Participant’s termination, the Participant engaged in conduct which would
constitute Cause, then such Participant shall forthwith cease to have any right to exercise any Option. 
 (e)    A
Participant to whom an Option has been granted under the Plan who is absent from the Company or an Affiliate because of temporary disability (any disability other than a Disability as defined in Paragraph 1 hereof), or who is on leave of absence for
any purpose, shall not, during the period of any such absence, be deemed, by virtue of such absence alone, to have terminated such Participant’s employment, director status or consultancy with the Company or with an Affiliate, except as the
Administrator may otherwise expressly provide; provided, however, that, for ISOs, any leave of absence granted by the Administrator of greater than ninety days, unless pursuant to a contract or statute that guarantees the right to reemployment,
shall cause such ISO to become a Non-Qualified Option on the 181st day following such leave of absence. 

(f)    Except as required by law or as set forth in a Participant’s Option Agreement, Options granted under the Plan
shall not be affected by any change of a Participant’s status within or among the Company and any Affiliates, so long as the Participant continues to be an Employee, director or Consultant of the Company or any Affiliate. 

  
 12 

	14.	EFFECT ON OPTIONS OF TERMINATION OF SERVICE FOR CAUSE. 

 Except as otherwise provided in
a Participant’s Option Agreement, the following rules apply if the Participant’s service (whether as an Employee, director or Consultant) with the Company or an Affiliate is terminated for Cause prior to the time that all his or her
outstanding Options have been exercised: 
 (a)    All outstanding and unexercised Options as of the time the
Participant is notified his or her service is terminated for Cause will immediately be forfeited. 
 (b)    Cause is not
limited to events which have occurred prior to a Participant’s termination of service, nor is it necessary that the Administrator’s finding of Cause occur prior to termination. If the Administrator determines, subsequent to a
Participant’s termination of service but prior to the exercise of an Option, that either prior or subsequent to the Participant’s termination the Participant engaged in conduct which would constitute Cause, then the right to exercise any
Option is forfeited. 
  

	15.	EFFECT ON OPTIONS OF TERMINATION OF SERVICE FOR DISABILITY. 

 Except as otherwise
provided in a Participant’s Option Agreement: 
 (a)    A Participant who ceases to be an Employee, director or
Consultant of the Company or of an Affiliate by reason of Disability may exercise any Option granted to such Participant: 
  

	 	(i)	To the extent that the Option has become exercisable but has not been exercised on the date of the Participant’s termination of service due to Disability; and 

 

	 	(ii)	In the event rights to exercise the Option accrue periodically, to the extent of a pro rata portion through the date of the Participant’s termination of service due to Disability of any additional vesting rights
that would have accrued on the next vesting date had the Participant not become Disabled. The proration shall be based upon the number of days accrued in the current vesting period prior to the date of the Participant’s termination of
service due to Disability. 

 (b)    A Disabled Participant may exercise the Option only within (i) if the
Option is an ISO, the period ending one year after the date of the Participant’s termination due to Disability or, if earlier, within the originally prescribed term of the Option, or (ii) if the Option is a Non-Qualified Option, within the
remaining term of the Option, notwithstanding that the Participant might have been able to exercise the Option as to some or all of the Shares on a later date if the Participant had not become Disabled and had continued to be an Employee, director
or Consultant. 

  
 13 

 (c)    The Administrator shall make the determination both of whether
Disability has occurred and the date of its occurrence (unless a procedure for such determination is set forth in another agreement between the Company and such Participant, in which case such procedure shall be used for such determination). If
requested, the Participant shall be examined by a physician selected or approved by the Administrator, the cost of which examination shall be paid for by the Company. 
  

	16.	EFFECT ON OPTIONS OF DEATH WHILE AN EMPLOYEE, DIRECTOR OR CONSULTANT. 

 Except as
otherwise provided in a Participant’s Option Agreement: 
 (a)    In the event of the death of a Participant while
the Participant is an Employee, director or Consultant of the Company or of an Affiliate, such Option shall become fully exercisable as of the date of the Participant’s death. 

(b)    If the Participant’s Survivors wish to exercise the Option, they must take all necessary steps to exercise the
Option within the originally prescribed term of the Option. 
  

	17.	EFFECT OF TERMINATION OF SERVICE ON UNACCEPTED STOCK GRANTS. 

 In the event of a
termination of service (whether as an Employee, director or Consultant) with the Company or an Affiliate for any reason before the Participant has accepted a Stock Grant, such offer shall terminate. 

For purposes of this Paragraph 17 and Paragraph 18 below, a Participant to whom a Stock Grant has been offered and accepted under the Plan who
is absent from work with the Company or with an Affiliate because of temporary disability (any disability other than a Disability as defined in Paragraph 1 hereof), or who is on leave of absence for any purpose, shall not, during the period of any
such absence, be deemed, by virtue of such absence alone, to have terminated such Participant’s employment, director status or consultancy with the Company or with an Affiliate, except as the Administrator may otherwise expressly provide. 

In addition, for purposes of this Paragraph 17 and Paragraph 18 below, any change of employment or other service within or among the Company
and any Affiliates shall not be treated as a termination of employment, director status or consultancy so long as the Participant continues to be an Employee, director or Consultant of the Company or any Affiliate. 

 

	18.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE OTHER THAN FOR CAUSE OR DEATH OR DISABILITY. 

Except as otherwise provided in a Participant’s Stock Grant Agreement, in the event of a termination of service (whether as an Employee,
director or Consultant), other than termination for Cause, Disability, or death for which events there are special rules in Paragraphs 19, 20, and 21, respectively, before all forfeiture provisions or Company rights of repurchase shall have lapsed,
then the Company shall have the right to cancel or repurchase that number of Shares subject to a Stock Grant as to which the Company’s forfeiture or repurchase rights have not lapsed. 

  
 14 

	19.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE FOR CAUSE. 

 Except as otherwise
provided in a Participant’s Stock Grant Agreement, the following rules apply if the Participant’s service (whether as an Employee, director or Consultant) with the Company or an Affiliate is terminated for Cause: 

(a)    All Shares subject to any Stock Grant that remain subject to forfeiture provisions or as to which the Company shall
have a repurchase right shall be immediately forfeited to the Company as of the time the Participant is notified his or her service is terminated for Cause. 

(b)    Cause is not limited to events which have occurred prior to a Participant’s termination of service, nor is it
necessary that the Administrator’s finding of Cause occur prior to termination. If the Administrator determines, subsequent to a Participant’s termination of service, that either prior or subsequent to the Participant’s
termination the Participant engaged in conduct which would constitute Cause, then all Shares subject to any Stock Grant that remained subject to forfeiture provisions or as to which the Company had a repurchase right on the date of termination shall
be immediately forfeited to the Company. 
  

	20.	EFFECT ON STOCK GRANTS OF TERMINATION OF SERVICE FOR DISABILITY. 

 Except as otherwise
provided in a Participant’s Stock Grant Agreement, the following rules apply if a Participant ceases to be an Employee, director or Consultant of the Company or of an Affiliate by reason of Disability: to the extent the forfeiture
provisions or the Company’s rights of repurchase have not lapsed on the date of the Participant’s termination due to Disability, they shall be exercisable; provided, however, that in the event such forfeiture provisions or rights of
repurchase lapse periodically, such provisions or rights shall lapse to the extent of a pro rata portion of the Shares subject to such Stock Grant through the date of the Participant’s termination due to Disability as would have lapsed had the
Participant not been terminated due to Disability. The proration shall be based upon the number of days accrued prior to the date of the Participant’s termination due to Disability. 

The Administrator shall make the determination both as to whether Disability has occurred and the date of its occurrence (unless a procedure
for such determination is set forth in another agreement between the Company and such Participant, in which case such procedure shall be used for such determination). If requested, the Participant shall be examined by a physician selected or
approved by the Administrator, the cost of which examination shall be paid for by the Company. 
  

	21.	EFFECT ON STOCK GRANTS OF DEATH WHILE AN EMPLOYEE, DIRECTOR OR CONSULTANT. 

 Except as
otherwise provided in a Participant’s Stock Grant Agreement, the following rules apply in the event of the death of a Participant while the Participant is an Employee, director or 

  
 15 

 
Consultant of the Company or of an Affiliate: to the extent the forfeiture provisions or the Company’s rights of repurchase have not lapsed on the date of death, they shall lapse in
full on the Participant’s date of death. 
  

	22.	PURCHASE FOR INVESTMENT. 

 Unless the offering and sale of the Shares to be issued upon
the particular exercise or acceptance of a Stock Right shall have been effectively registered under the Securities Act, the Company shall be under no obligation to issue the Shares covered by such exercise unless and until the following conditions
have been fulfilled: 
 (a)    The person who exercises or accepts such Stock Right shall warrant to the Company, prior
to the receipt of such Shares, that such person is acquiring such Shares for his or her own account, for investment, and not with a view to, or for sale in connection with, the distribution of any such Shares, in which event the person acquiring
such Shares shall be bound by the provisions of the following legend (or a legend in substantially similar form) which shall be endorsed upon the certificate evidencing the Shares issued pursuant to such exercise or such grant: 

“The shares represented by this certificate have been taken for investment and they may not be sold or otherwise transferred by any
person, including a pledgee, unless (1) either (a) a Registration Statement with respect to such shares shall be effective under the Securities Act of 1933, as amended, or (b) the Company shall have received an opinion of counsel satisfactory to it
that an exemption from registration under such Act is then available, and (2) there shall have been compliance with all applicable state securities laws.” 

(b)    At the discretion of the Administrator, the Company shall have received an opinion of its counsel that the Shares
may be issued upon such particular exercise or acceptance in compliance with the Securities Act without registration thereunder. 
  

	23.	DISSOLUTION OR LIQUIDATION OF THE COMPANY. 

 Upon the dissolution or liquidation of the
Company, all Options granted under this Plan which as of such date shall not have been exercised and all Stock Grants and Stock-Based Awards which have not been accepted will terminate and become null and void; provided, however, that if the rights
of a Participant or a Participant’s Survivors have not otherwise terminated and expired, the Participant or the Participant’s Survivors will have the right immediately prior to such dissolution or liquidation to exercise or accept any
Stock Right to the extent that the Stock Right is exercisable or subject to acceptance as of the date immediately prior to such dissolution or liquidation. Upon the dissolution or liquidation of the Company, any outstanding Stock-Based Awards
shall immediately terminate unless otherwise determined by the Administrator or specifically provided in the applicable Agreement. 

  
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	24.	ADJUSTMENTS. 

 Upon the occurrence of any of the following events, a Participant’s
rights with respect to any Stock Right granted to him or her hereunder shall be adjusted as hereinafter provided, unless otherwise specifically provided in a Participant’s Agreement: 

(a)    Stock Dividends and Stock Splits. If (i) the shares of Common Stock shall be subdivided or
combined into a greater or smaller number of shares or if the Company shall issue any shares of Common Stock as a stock dividend on its outstanding Common Stock, or (ii) additional shares or new or different shares or other securities of the
Company or other non-cash assets are distributed with respect to such shares of Common Stock, the number of shares of Common Stock deliverable upon the exercise of an Option or acceptance of a Stock Grant shall be appropriately increased or
decreased proportionately, and appropriate adjustments shall be made including, in the exercise or purchase price per share, to reflect such events. The number of Shares subject to the limitations in Paragraph 3(a) and 4(c) shall also be
proportionately adjusted upon the occurrence of such events. 
 (b)     Corporate Transactions. If the
Company is to be consolidated with or acquired by another entity in a merger, consolidation, or sale of all or substantially all of the Company’s assets other than a transaction to merely change the state of incorporation (a “Corporate
Transaction”), the Administrator or the board of directors of any entity assuming the obligations of the Company hereunder (the “Successor Board”), shall, as to outstanding Options, either (i) make appropriate provision for the
continuation of such Options by substituting on an equitable basis for the Shares then subject to such Options either the consideration payable with respect to the outstanding shares of Common Stock in connection with the Corporate Transaction or
securities of any successor or acquiring entity; or (ii) upon written notice to the Participants, provide that such Options must be exercised (either (A) to the extent then exercisable or, (B) at the discretion of the Administrator, including upon a
Change of Control of the Company, any such Options being made fully exercisable for purposes of this Subparagraph), within a specified number of days of the date of such notice, at the end of which period such Options which have not been exercised
shall terminate; or (iii) terminate such Options in exchange for payment of an amount equal to the consideration payable upon consummation of such Corporate Transaction to a holder of the number of shares of Common Stock into which such Option would
have been exercisable (either (A) to the extent then exercisable or, (B) at the discretion of the Administrator, any such Options being made fully exercisable for purposes of this Subparagraph) less the aggregate exercise price
thereof. For purposes of determining the payments to be made pursuant to Subclause (iii) above, in the case of a Corporate Transaction the consideration for which, in whole or in part, is other than cash, the consideration other than cash shall
be valued at the fair value thereof as determined in good faith by the Board of Directors. 
 With respect to outstanding Stock Grants, the
Administrator or the Successor Board, shall make appropriate provision for the continuation of such Stock Grants on the same terms and conditions by substituting on an equitable basis for the Shares then subject to such Stock Grants either the
consideration payable with respect to the outstanding Shares of Common Stock in connection with the Corporate Transaction or securities of any successor or acquiring entity. In lieu of the foregoing, in connection with any Corporate
Transaction, the Administrator may provide that, upon consummation of the Corporate Transaction, each outstanding Stock Grant shall be terminated in exchange for payment of an amount equal to the consideration payable upon consummation of such
Corporate Transaction to a holder of the number of shares of Common Stock comprising such 

  
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Stock Grant (to the extent such Stock Grant is no longer subject to any forfeiture or repurchase rights then in effect or, at the discretion of the Administrator, all forfeiture and repurchase
rights being waived upon such Corporate Transaction). 
 In taking any of the actions permitted under this Paragraph 24(b), the
Administrator shall not be obligated by the Plan to treat all Stock Rights, all Stock Rights held by a Participant, or all Stock Rights of the same type, identically. 

(c)    Recapitalization or Reorganization. In the event of a recapitalization or reorganization of the Company
other than a Corporate Transaction pursuant to which securities of the Company or of another corporation are issued with respect to the outstanding shares of Common Stock, a Participant upon exercising an Option or accepting a Stock Grant after the
recapitalization or reorganization shall be entitled to receive for the price paid upon such exercise or acceptance if any, the number of replacement securities which would have been received if such Option had been exercised or Stock Grant accepted
prior to such recapitalization or reorganization. 
 (d)    Adjustments to Stock-Based Awards. Upon the
happening of any of the events described in Subparagraphs (a), (b) or (c) above, any outstanding Stock-Based Award shall be appropriately adjusted to reflect the events described in such Subparagraphs. The Administrator or the Successor Board
shall determine the specific adjustments to be made under this Paragraph 24, including, but not limited to the effect of any, Corporate Transaction or Change of Control and, subject to Paragraph 4, its determination shall be conclusive. 

(e)     Modification of Options. Notwithstanding the foregoing, any adjustments made pursuant to Subparagraph
(a), (b) or (c) above with respect to Options shall be made only after the Administrator determines whether such adjustments would constitute a “modification” of any ISOs (as that term is defined in Section 424(h) of the Code) or
would cause any adverse tax consequences for the holders of Options, including, but not limited to, pursuant to Section 409A of the Code. If the Administrator determines that such adjustments made with respect to Options would constitute a
modification or other adverse tax consequence, it may refrain from making such adjustments, unless the holder of an Option specifically agrees in writing that such adjustment be made and such writing indicates that the holder has full knowledge of
the consequences of such “modification” on his or her income tax treatment with respect to the Option. This paragraph shall not apply to the acceleration of the vesting of any ISO that would cause any portion of the ISO to violate the
annual vesting limitation contained in Section 422(d) of the Code, as described in Paragraph 6(b)(iv). 
  

	25.	ISSUANCES OF SECURITIES. 

 Except as expressly provided herein, no issuance by the
Company of shares of stock of any class, or securities convertible into shares of stock of any class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares subject to Stock Rights. Except
as expressly provided herein, no adjustments shall be made for dividends paid in cash or in property (including without limitation, securities) of the Company prior to any issuance of Shares pursuant to a Stock Right. 

  
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	26.	FRACTIONAL SHARES. 

 No fractional shares shall be issued under the Plan and the person
exercising a Stock Right shall receive from the Company cash in lieu of such fractional shares equal to the Fair Market Value thereof. 
  

	27.	CONVERSION OF ISOS INTO NON-QUALIFIED OPTIONS; TERMINATION OF ISOS. 

The Administrator, at the written request of any Participant, may in its discretion take such actions as may be necessary to convert such
Participant’s ISOs (or any portions thereof) that have not been exercised on the date of conversion into Non-Qualified Options at any time prior to the expiration of such ISOs, regardless of whether the
Participant is an Employee of the Company or an Affiliate at the time of such conversion. At the time of such conversion, the Administrator (with the consent of the Participant) may impose such conditions on the exercise of the resulting Non-Qualified Options as the Administrator in its discretion may determine, provided that such conditions shall not be inconsistent with this Plan. Nothing in the Plan shall be deemed to give any Participant
the right to have such Participant’s ISOs converted into Non-Qualified Options, and no such conversion shall occur until and unless the Administrator takes appropriate action. The Administrator, with
the consent of the Participant, may also terminate any portion of any ISO that has not been exercised at the time of such conversion. 
  

	28.	WITHHOLDING. 

 In the event that any federal, state, or local income taxes, employment
taxes, Federal Insurance Contributions Act (“F.I.C.A.”) withholdings or other amounts are required by applicable law or governmental regulation to be withheld from the Participant’s salary, wages or other remuneration in connection
with the exercise or acceptance of a Stock Right or in connection with a Disqualifying Disposition (as defined in Paragraph 29) or upon the lapsing of any forfeiture provision or right of repurchase or for any other reason required by law, the
Company may withhold from the Participant’s compensation, if any, or may require that the Participant advance in cash to the Company, or to any Affiliate of the Company which employs or employed the Participant, the statutory minimum amount of
such withholdings unless a different withholding arrangement, including the use of shares of the Company’s Common Stock or a promissory note, is authorized by the Administrator (and permitted by law). For purposes hereof, the fair market
value of the shares withheld for purposes of payroll withholding shall be determined in the manner set forth under the definition of Fair Market Value provided in Paragraph 1 above, as of the most recent practicable date prior to the date of
exercise. If the Fair Market Value of the shares withheld is less than the amount of payroll withholdings required, the Participant may be required to advance the difference in cash to the Company or the Affiliate employer. The
Administrator in its discretion may condition the exercise of an Option for less than the then Fair Market Value on the Participant’s payment of such additional withholding.

  
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	29.	NOTICE TO COMPANY OF DISQUALIFYING DISPOSITION. 

 Each Employee who receives an ISO must
agree to notify the Company in writing immediately after the Employee makes a Disqualifying Disposition of any Shares acquired pursuant to the exercise of an ISO. A Disqualifying Disposition is defined in Section 424(c) of the Code and includes
any disposition (including any sale or gift) of such Shares before the later of (a) two years after the date the Employee was granted the ISO, or (b) one year after the date the Employee acquired Shares by exercising the ISO, except as otherwise
provided in Section 424(c) of the Code. If the Employee has died before such Shares are sold, these holding period requirements do not apply and no Disqualifying Disposition can occur thereafter. 

 

	30.	TERMINATION OF THE PLAN. 

 The Plan will terminate on September 15, 2020, the date which
is ten years from the earlier of the date of its adoption by the Board of Directors and the date of its approval by the shareholders of the Company. The Plan may be terminated at an earlier date by vote of the shareholders or the Board
of Directors of the Company; provided, however, that any such earlier termination shall not affect any Agreements executed prior to the effective date of such termination. Termination of the Plan shall not affect any Stock Rights theretofore
granted. 
  

	31.	AMENDMENT OF THE PLAN AND AGREEMENTS. 

 The Plan may be amended by the shareholders of
the Company. The Plan may also be amended by the Administrator, including, without limitation, to the extent necessary to qualify any or all outstanding Stock Rights granted under the Plan or Stock Rights to be granted under the Plan for
favorable federal income tax treatment as may be afforded incentive stock options under Section 422 of the Code (including deferral of taxation upon exercise), and to the extent necessary to qualify the shares issuable upon exercise or acceptance of
any outstanding Stock Rights granted, or Stock Rights to be granted, under the Plan for listing on any national securities exchange or quotation in any national automated quotation system of securities dealers. Any amendment approved by the
Administrator which the Administrator determines is of a scope that requires shareholder approval shall be subject to obtaining such shareholder approval. Any modification or amendment of the Plan shall not, without the consent of a
Participant, adversely affect his or her rights under a Stock Right previously granted to him or her. With the consent of the Participant affected, the Administrator may amend outstanding Agreements in a manner which may be adverse to the
Participant but which is not inconsistent with the Plan. In the discretion of the Administrator, outstanding Agreements may be amended by the Administrator in a manner which is not adverse to the Participant. 

 

	32.	EMPLOYMENT OR OTHER RELATIONSHIP. 

 Nothing in this Plan or any Agreement shall be deemed
to prevent the Company or an Affiliate from terminating the employment, consultancy or director status of a Participant, nor to prevent a Participant from terminating his or her own employment, consultancy or director status or to give any
Participant a right to be retained in employment or other service by the Company or any Affiliate for any period of time. 

  
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	33.	GOVERNING LAW. 

 This Plan shall be construed and enforced in accordance with the law of
the State of Delaware. 

  
 21

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