Document:

EX-4.21

 Exhibit 4.21 

CDC-    A 

AMENDMENT TO 
 WARRANT TO
PURCHASE SHARES OF COMMON STOCK OF 
 AMEDICA CORPORATION 

This Amendment to Warrant to Purchase Shares of Common Stock (this “Amendment”) dated as of
December 23, 2013, is made by and between Amedica Corporation, a Delaware corporation (the “Company”), and the undersigned, TGP Securities, Inc. (the “Warrant Holder”), and it hereby amends that
certain Warrant to Purchase Shares of Common Stock of the Company originally issued as of [August 30/September 19], 2013 (the “Existing Warrant”), in connection with the Company’s offering of up to 100 units wherein each
unit consisted of 50,000 shares of the Company’s Series F Convertible Preferred Stock and one five year warrant to acquire 25,000 shares of the Company’s common stock exercisable at $1.00 per share. 

NOW, THEREFORE, in consideration of the mutual promises contained herein, and the benefits to be derived by each party hereunder, and for
other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and Warrant Holder, intending to be legally bound, hereby agree to amend the Existing Warrant, as set forth below and hereby agree as
follows: 
 AGREEMENT: 

Section 1. Amendments to Section 4 - Adjustments to Shares and Stated Purchase Price. Section 4 of the Existing
Warrant is hereby amended by inserting an additional paragraph immediately following Section 4(b) as follows: 

“(c) If the Company at any time after the date hereof through the Warrant Expiration Date issues or sells any stock or
other security (other than warrants or options to subscribe for or purchase shares of Common Stock or Preferred Stock granted to employees or consultants to the Company or securities (including warrants) issued by the Company in connection with the
closing of an initial public offering of Common Stock, or any strategic collaboration, license, or other similar transaction) that is at any time and under any circumstances, directly or indirectly convertible into, exercisable or exchangeable for,
or which otherwise entitles the holder thereof to acquire any shares of Common Stock or Preferred Stock (the “Convertible Securities”), for a consideration per share less than the Stated Purchase Price then in effect or for which
the Convertible Securities have a conversion rate of less than the Stated Purchase Price then in effect, then the Stated Purchase Price in effect immediately prior to such issuance or sale will be reduced, concurrently with such issue, to the
consideration per share received by the Company for such issuance or sale.” 
 Section 2. No Further Amendments.
Except as expressly amended hereby, the Existing Warrant is in all respects ratified and confirmed and all the terms, conditions, and provisions thereof shall remain in full force and effect. 

 Section 3. Effect of Amendment. This Amendment shall form a part of the
Existing Warrant for all purposes, and each party thereto and hereto shall be bound hereby. From and after the execution of this Amendment by the parties hereto, any reference to the Existing Warrant shall be deemed a reference to the Existing
Warrant as amended hereby.  
 Section 4. Headings. The descriptive headings contained in this Amendment are
included for convenience of reference only and shall not affect in any way the meaning or interpretation of this Amendment. 

Section 5. Counterparts; Facsimiles. This Amendment may be executed in one or more counterparts, and by the different
parties hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same agreement. A facsimile or other electronically transmitted signature on this
Amendment is as valid as an original signature. 
 Section 6. Governing Law. This Amendment and the rights and
duties of the parties hereto shall be governed by, and construed and enforced in accordance with, the laws of the State of Delaware.  

IN WITNESS WHEREOF, the Company and Warrant Holder have caused this Amendment to Warrant to Purchase Shares of Common Stock of Amedica
Corporation to be executed and delivered as of the date first written above by their respective officers thereunto duly authorized. 
  

									
	THE COMPANY:	 		 	WARRANT HOLDER:
			
	AMEDICA CORPORATION	 		 	TGP SECURITIES, INC.
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Eric K. Olson	 		 		 	      Print/Type Name:
	Title:	 	President and CEO	 		 		 	      Print/Type Title:EX-10.4.1

 Exhibit 10.4.1 

FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT 

THIS FOURTH AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Amendment”), dated as of December 23, 2013, is
entered into by and among AMEDICA CORPORATION, a Delaware corporation (“Borrower”), US SPINE, INC., a Delaware corporation (“Guarantor”), the Lenders (as defined below) and GENERAL ELECTRIC CAPITAL
CORPORATION, a Delaware corporation (“GECC”), in its capacity as administrative and collateral agent (together with its successors and assigns in such capacity, the “Agent”) for the Lenders (as defined below).

 W I T N E S S E T H: 

WHEREAS, Borrower, Guarantor, Agent, and the lenders signatory thereto from time to time (each a “Lender” and,
collectively, the “Lenders”), are parties to that certain Loan and Security Agreement, dated as of December 17, 2012 (as has been and may be amended, restated, supplemented, replaced, and otherwise modified from time to time,
the “Loan Agreement”; capitalized terms used herein have the meanings given to them in the Loan Agreement except as otherwise expressly defined herein), pursuant to which Lenders and Agent have agreed to provide to Borrower certain
loans in accordance with the terms and conditions thereof; and 
 WHEREAS, Borrower, Lenders, and Agent desire to amend
certain provisions of the Loan Agreement as provided herein; 
 NOW, THEREFORE, in consideration of the premises, the covenants and
agreements contained herein, and other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, Borrower, Lenders and Agent hereby agree as follows: 

1 AMENDMENTS TO LOAN AGREEMENT. Subject to the terms and conditions of this Amendment, including, without limitation, Section 4 of this
Amendment, the Loan Agreement is hereby amended as follows: 
 (a) Liquidity Covenant. Section 7.10(b) of the Loan Agreement
shall not be tested for the period from November 1, 2013 until January 31, 2014. Such limitation shall cease to be effective as of February 1, 2014 and thereafter, during which Borrower shall be required to comply with
Section 7.10(b) of the Loan Agreement. 
 2 RESERVE. On the date hereof, Agent shall establish a Reserve pursuant to
Section 2.1(b) of the Loan Agreement, in the amount of $500,000 (the “Fourth Amendment Reserve”), which shall remain in place until removed by Agent in its Permitted Discretion. For the avoidance of doubt, the Fourth
Amendment Reserve is in addition to the $500,000 Reserve established pursuant to that certain Third Amendment and Waiver to Loan and Secured Agreement dated as of August 15, 2013, by and among Borrower, Guarantor, Agent and Lenders. 

3 AMENDMENT FEE. Borrower shall pay to Agent, for the benefit of Lenders in accordance with their Pro Rata Shares, an amendment fee in an amount
equal to $860,000 (provided that such fee shall be (i) $430,000 if Borrower has terminated the Revolving Loan 

  
 [Amedica] Fourth Amendment

 
Commitments and paid all Obligations in full on or prior to January 31, 2014, or (ii) $645,000 if Borrower has terminated the Revolving Loan Commitments and paid all Obligations in full
after January 31, 2014, but on or prior to February 28, 2014, “Fourth Amendment Fee”), which fee shall be fully earned on the date hereof, and payable on the earlier of (x) the date all Obligations have been paid in
full and the Revolving Loan Commitments terminated, or (ii) March 1, 2014. 
 4 CONDITIONS TO EFFECTIVENESS. This Amendment shall
become effective upon satisfaction of each of the following conditions: 
 (a) No Default or Event of Default shall have occurred and be
continuing; 
 (b) Agent shall have received one or more counterparts of this Amendment, duly executed, completed and delivered by Agent,
each Lender and each Loan Party; and 
 (c) Agent shall have received all other documents and instruments as Agent or any Lender may
reasonably deem necessary or appropriate to effectuate the intent and purpose of this Amendment. 
 5 REAFFIRMATION OF LOAN DOCUMENTS. By
executing and delivering this Amendment, each Loan Party hereby (i) reaffirms, ratifies and confirms its Obligations under the Loan Agreement and the other Loan Documents, (ii) agrees that this Amendment shall be a “Loan
Document” under the Loan Agreement and (iii) hereby expressly agrees that the Loan Agreement and each other Loan Document shall remain in full force and effect following any action contemplated in connection herewith. 

6 REAFFIRMATION OF GRANT OF SECURITY INTEREST IN COLLATERAL. Each Loan Party hereby expressly reaffirms, ratifies and confirms its obligations
under the Loan Agreement, including its grant, pledge and hypothecation to the Agent for the benefit of the Agent and each Lender, of the lien on and security interest in, all of its right, title and interest in, all of the Collateral. 

7 NO OTHER CONSENTS OR AMENDMENTS. Except for the amendments set forth in Section 1 of this Amendment, the Loan Agreement and the
other Loan Documents shall remain unchanged and in full force and effect. Nothing in this Amendment is intended, or shall be construed, to constitute a novation or an accord and satisfaction of any Loan Party’s Obligations under or in
connection with the Loan Agreement and any other Loan Document or to modify, affect or impair the perfection or continuity of Agent’s security interest in, (on behalf of itself and Lenders) security titles to or other liens on any Collateral
for the Obligations. 
 8 REPRESENTATIONS AND WARRANTIES; LIENS; NO DEFAULT, NO CONFLICT. Each Loan Party hereby represents, warrants and
covenants with and to the Agent and Lenders as follows: (i) all of the representations and warranties set forth in the Loan Documents continue to be true and correct as of the date hereof, except to the extent such representations and
warranties by their terms expressly relate only to a prior date (in which case such representations and warranties shall be true and correct as of such prior date); (ii) there are no Defaults or Events of Default that have not been waived or
cured; (iii) Agent has and shall continue to have valid, enforceable and perfected first-priority liens, subject only to Permitted Liens, on and security interests in the Collateral and all other collateral heretofore granted by

  
 [Amedica] Fourth Amendment

  
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each Loan Party to Agent, for the benefit of the Agent and each Lender, pursuant to the Loan Documents or otherwise granted to or held by Agent, for the benefit of the Agent and each Lender,
(iv) the agreements and obligations of Loan Parties contained in the Loan Documents and in this Amendment constitute the legal, valid and binding obligations of the Loan Parties party thereto, enforceable against each such Loan Party in
accordance with their respective terms, except as the enforceability thereof may be limited by bankruptcy, insolvency or other similar laws of general application affecting the enforcement of creditors’ rights or by the application of general
principles of equity, and (v) the execution, delivery and performance of this Amendment by each Loan Party will not violate any law, rule, regulation or order or contractual obligation or organizational document of such Loan Party and will not
result in, or require, the creation or imposition of any lien, claim or encumbrance of any kind on any of its properties or revenues. 
 9 ADVICE OF
COUNSEL. Each of the parties represents to each other party hereto that it has discussed this Amendment with its counsel. 
 10 SEVERABILITY
OF PROVISIONS. In case any provision of or obligation under this Amendment shall be invalid, illegal or unenforceable in any applicable jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of
such provision or obligation in any other jurisdiction, shall not in any way be affected or impaired thereby. 
 11 FURTHER ASSURANCES. Each
Loan Party agrees that at any time and from time to time, at the expense of each Loan Party, it will promptly execute and deliver all further instruments and documents, and take all further action, that may be necessary or that Agent or Lenders may
reasonably request, in connection with this Amendment, or to enable them to exercise and enforce their rights and remedies under this Amendment, the Loan Agreement and the other Loan Documents. 

12 COSTS AND EXPENSES. Each Loan Party shall be responsible for the payment of all fees, costs and expenses incurred by Agent and Lenders in
connection with the preparation and negotiation of this Amendment, including, without limitation, any and all fees and expenses of Agent’s and Lenders’ counsel. 

13 REFERENCE TO THE EFFECT ON THE LOAN AGREEMENT. 

(a) Upon the effectiveness of this Amendment, each reference in the Loan Agreement to “this Agreement,” “hereunder,”
“hereof,” “herein” or words of similar import shall mean and be a reference to the Loan Agreement as modified by this Amendment. 

(b) The execution, delivery and effectiveness of this Amendment shall not, except as expressly provided in this Amendment, operate as a waiver
of any right, power or remedy of Agent or any Lender, nor constitute a waiver of any provision of the Loan Agreement or any other documents, instruments and agreements executed or delivered in connection with the Loan Agreement. 

14 ACKNOWLEDGMENT OF EACH LOAN PARTY. Each Loan Party hereby acknowledges and agrees that: (i) it has no defense, offset or counterclaim
with respect to the payment of any sum owed to Agent or Lenders, or with respect to the performance or observance of any warranty or covenant contained in the Loan Documents; and (ii) Agent and Lenders have performed all obligations and duties
owed to each Loan Party through the date hereof. 

  
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 15 GOVERNING LAW. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE
INTERNAL LAWS OF THE STATE OF NEW YORK APPLICABLE TO CONTRACTS MADE AND PERFORMED IN SUCH STATE WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING CONFLICTS OF LAWS. 

16 HEADINGS. Section headings in this Amendment are included for convenience of reference only and shall not constitute a part of this Amendment
for any other purpose. 
 17 ENTIRE AGREEMENT. The Loan Agreement and the other Loan Documents as and when amended through this Amendment
embody the entire agreement between the parties hereto relating to the subject matter thereof and supersede all prior agreements, representations and understandings, if any, relating to the subject matter thereof. 

18 COUNTERPARTS. This Amendment may be executed in multiple counterparts, each of which shall be deemed to be an original and all of which when
taken together shall constitute one and the same instrument. Delivery of an executed signature page of this Amendment by facsimile transmission, portable document format (.pdf), or other electronic transmission shall be as effective as delivery of a
manually executed counterpart hereof. 
 [Remainder of page intentionally blank; signature pages follow.] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Fourth Amendment to Loan and
Security Agreement to be duly executed and delivered as of the day and year specified at the beginning hereof. 
  

			
	BORROWER:
	
	AMEDICA CORPORATION
		
	By:	 	 /s/ Eric Olson

	Name:	 	 Eric Olson

	Title:	 	 President and CEO

	
	GUARANTOR:
	
	US SPINE, INC.
		
	By:	 	 /s/ Eric Olson

	Name:	 	 Eric Olson

	Title:	 	 President and CEO

	
	AGENT AND LENDER:
	
	GENERAL ELECTRIC CAPITAL CORPORATION, as Agent and Lender
		
	By:	 	 /s/ Scott R. Towers

	Name:	 	 Scott R. Towers

	Title:	 	 Duly Authorized Signatory

	
	LENDER:
	
	ZIONS FIRST NATIONAL BANK
		
	By:	 	 /s/ Thomas C. Etzel

	Name:	 	 Thomas C. Etzel

	Title:	 	 Senior Vice President

  
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signature page

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