Document:

EX-10.1

Exhibit 10.1

STOCK PURCHASE AGREEMENT

     This Stock Purchase Agreement is dated as of February 23, 2009 (this “Agreement”),
between OPKO Health, Inc., a Delaware corporation (the “Company”), and the purchasers
listed on Annex A hereto (collectively, the “Purchasers”).

     WHEREAS, the Company desires to sell to Purchasers, and Purchasers desire to purchase from the
Company, shares of the Company’s common stock, par value $.01 per share (the “Common
Stock”), on the terms and subject to the conditions set forth in this Agreement (the
“Transaction”).

     WHEREAS, the Purchase Price and the Shares (as hereinafter defined) issued shall be allocated
among the Purchasers in accordance with Annex A. 

     NOW, THEREFORE, in consideration of the premises and the mutual covenants contained in this
Agreement and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, and intending to be legally bound, the parties agree as follows:

Article 1

Purchase and Sale of Common Stock

     1.1 Purchase and Sale of the Shares. Subject to the terms and conditions hereof, the
Company hereby agrees to issue and sell to Purchasers, and Purchasers hereby agree to purchase from
the Company, 20,000,000 shares of Common Stock (the “Shares”) at a purchase price of $1.00 per
share for an aggregate purchase price of $20 million (the “Purchase Price”).

     1.2 Closing. The closing of the issuance and sale of the Shares (the
“Closing”) shall take place at the Company’s offices in Miami, Florida on, or as soon as
possible following the later of (i) the date which is twenty (20) days after the Company first
mails to stockholders an Information Statement on Schedule 14C notifying stockholders that the
Transaction was approved by the written consent of stockholders holding a majority of the voting
power of the outstanding capital stock of the Company or (ii) the expiration or termination of any
waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “HSR
Act”), and the rules of the Federal Trade Commission relating to the HSR Act (the “Closing”). As
payment in full for the Shares being purchased by them at the Closing, Purchasers shall pay to the
Company the Purchase Price by wire transfer.

Article 2

Additional Agreements

     The Company and Purchasers shall cooperate with each other and use their respective
commercially reasonable best efforts to take or cause to be taken all actions, and do or cause to
be done all things, necessary, proper or advisable under this Agreement and applicable laws and
regulations to consummate and make effective the sale of the Shares (the “Sale”) and the
other transactions contemplated by this Agreement as soon as practicable, including preparing and
filing as promptly as practicable all documentation to effect all necessary applications,
notices, petitions, filings and other documents and to obtain as promptly as practicable all
permits, consents, approvals and authorizations necessary or advisable to be obtained from any
third party and/or any governmental entity in order to consummate the Sale or any of the other
transactions contemplated by this Agreement.

 

 

Article 3

Representations and Warranties of the Company

     The Company represents and warrants to Purchasers as of the date hereof as follows:

     3.1 Authorization of Agreements, etc. The execution and delivery by the Company of
this Agreement, the performance by the Company of its obligations hereunder, and the issuance, sale
and delivery of the Shares have been duly authorized by all requisite corporate action and will not
result in any violation of, be in conflict with, or constitute a default under, with or without the
passage of time or the giving of notice: (a) any provision of the Company’s Certificate of
Incorporation, as amended, or Bylaws, as amended; (b) any provision of any judgment, decree or
order to which the Company is a party or by which it is bound; (c) any material contract or
agreement to which the Company is a party or by which it is bound; or (d) any statute, rule or
governmental regulation applicable to the Company, except where such violation, conflict, or
default would not have a material adverse effect on the Company.

     3.2 Valid Issuance of Common Stock. The Shares have been duly authorized and, when
issued, sold and delivered in accordance with this Agreement for the consideration expressed herein
will be validly issued, fully paid and nonassessable with no personal liability attaching to the
ownership thereof and will be free and clear of all liens, charges and encumbrances of any nature
whatsoever except for restrictions on transfer under this Agreement and under applicable Federal
and state securities laws.

     3.3 Validity. This Agreement has been duly executed and delivered by the Company and
constitutes the legal, valid and binding obligation of the Company, enforceable in accordance with
its terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium,
and other laws of general application affecting enforcement of creditors’ rights generally, and
(ii) as limited by laws relating to the availability of specific performance, injunctive relief, or
other equitable remedies.

     3.4 Brokers and Finders. Neither the Company nor any of its subsidiaries, officers,
directors or employees has employed any broker or finder or incurred any liability for any
brokerage fees, commissions or finders’ fees in connection with the Sale or the other transactions
contemplated by this Agreement.

Article 4

Representations and Warranties of Purchasers

     Each of the Purchasers hereby severally and not jointly represents and warrants to the Company
as of the date hereof as follows:

     4.1 Validity. This Agreement has been duly executed and delivered by Purchaser and
constitutes the legal, valid and binding obligation of Purchaser, enforceable in accordance with
its terms except:

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          (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other
laws of general application affecting enforcement of creditors’ rights generally; and

          (b) as limited by laws relating to the availability of specific performance, injunctive
relief, or other equitable remedies.

     4.2 Investment Representations.

          (a) Purchaser is an “accredited investor” within the meaning of Rule 501 of Regulation D under
the Securities Act of 1933, as amended (the “Securities Act”) and was not organized for the
specific purpose of acquiring the Shares;

          (b) Purchaser has sufficient knowledge and experience in investing in companies similar to the
Company in terms of the Company’s stage of development so as to be able to evaluate the risks and
merits of its investment in the Company and it is able financially to bear the risks thereof;

          (c) it is the present intention that the Shares being purchased by Purchaser are being
acquired for Purchaser’s own account for the purpose of investment and not with a present view to
or for sale in connection with any distribution thereof;

          (d) Purchaser understands that:

               (i) the Shares have not been registered under the Securities Act by reason of their issuance
in a transaction exempt from the registration requirements of the Securities Act pursuant to
Section 4(2) thereof or Rule 505 or 506 promulgated under the Securities Act;

               (ii) the Shares must be held indefinitely unless a subsequent disposition thereof is
registered under the Securities Act or is exempt from such registration;

               (iii) the Shares will bear a legend to such effect; and

               (iv) the Company will make a notation on its transfer books to such effect; and

          (e) the Company has made available to Purchaser all documents and information that the
Purchaser has requested relating to an investment in the Company.

     4.3 Brokers and Finders. The Purchaser has not employed any broker or finder or
incurred any liability for any brokerage fees, commissions or finders’ fees in connection with the
Sale or the other transactions contemplated by this Agreement.

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Article 5

Miscellaneous

     5.1 Lock-Up. Each of the Purchasers hereby irrevocably agrees that until the second
anniversary of the date of Closing, he she or it will not, without the prior written consent of the
Company, directly or indirectly:

          (a) Offer for sale, sell, pledge or otherwise dispose of (or enter into any transaction or
device that is designed to, or could be expected to, result in the disposition by any person at any
time in the future, of any of the Shares;

          (b) Enter into any swap or other derivatives transaction that transfers to another, in whole
or in part, any of the economic benefits or risks of ownership of the Shares, or

          (c) Publicly disclose the intention to do any of the foregoing, for a period commencing on the
date hereof and ending on the second anniversary of the date hereof.

     5.2 Legend. Each certificate that represents Shares shall have conspicuously endorsed
thereon the following legends:

THIS STOCK HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“SECURITIES ACT”), OR ANY STATE SECURITIES LAWS. THIS STOCK MAY NOT BE OFFERED OR
TRANSFERRED BY SALE, ASSIGNMENT, PLEDGE OR OTHERWISE UNLESS (A) A REGISTRATION
STATEMENT FOR THE STOCK UNDER THE SECURITIES ACT IS IN EFFECT OR (B) THE COMPANY HAS
RECEIVED AN OPINION OF COUNSEL, WHICH OPINION IS SATISFACTORY TO THE COMPANY, TO THE
EFFECT THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OR THE
RELEVANT STATE SECURITIES LAWS.

THIS STOCK IS SUBJECT TO RESTRICTIONS ON RESALE PURSUANT TO THAT CERTAIN STOCK
PURCHASE AGREEMENT WITH THE COMPANY DATED FEBRUARY 23, 2009 AND MAY NOT BE OFFERED
OR TRANSFERRED BY SALE, ASSIGNMENT, PLEDGE OR OTHERWISE WITHOUT THE PRIOR WRITTEN
CONSENT OF THE COMPANY.

     5.3 Brokerage. Each party hereto will indemnify and hold harmless the other against
and in respect of any claim for brokerage or other commissions relative to this Agreement or to the
transactions contemplated hereby, based in any way on agreements, arrangements or understandings
made or claimed to have been made by such party with any third party.

     5.4 Parties in Interest. All representations, covenants and agreements contained in
this Agreement by or on behalf of any of the parties hereto shall bind and inure to the benefit of
the respective successors and assigns of the parties hereto whether so expressed or not.

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     5.5 Notices. All notices, requests, consents, demands, and other communications under
this Agreement shall be in writing and shall be deemed to have been duly given on the date of
service if served personally on the party to whom notice is to be given, on the date of transmittal
of services via telecopy to the party to whom notice is to be given (with a confirming copy
delivered within 24 hours thereafter), or on the third day after mailing if mailed to the party to
whom notice is to be given, by first class mail, registered or certified, postage prepaid, or
overnight mail via a nationally recognized courier providing a receipt for delivery and properly
addressed as follows:

	 	 	 
	If to the Company:

	 	OPKO Health, Inc.
	 

	 	4400 Biscayne Blvd.
	 

	 	Suite 1180
	 

	 	Miami, FL 33137
	 

	 	Attn: Kate Inman, Esq.
	 
	 	 
	If to any of the Purchasers:

	 	To the address specified on the signature pages hereto.

Any party may change its address for purposes of this paragraph by giving notice of the new address
to each of the other parties in the manner set forth above.

     5.6 Governing Law. This Agreement shall be governed by and construed in accordance
with the laws of the State of Florida for all purposes and in all respects, without regard to the
conflict of law provisions of such state.

     5.7 Entire Agreement. This Agreement constitutes the sole and entire agreement of the
parties with respect to the subject matter hereof.

     5.8 Counterparts. This Agreement may be executed in two or more counterparts
(including facsimiles), each of which shall be deemed an original, but all of which together shall
constitute one and the same instrument.

     5.9 Amendments and Waivers. This Agreement may be amended or modified, and provisions
hereof may be waived, only with the written consent of the Company and the Purchasers.

     5.10 Severability. If any provision of this Agreement shall be declared void or
unenforceable by any judicial or administrative authority, the validity of any other provision and
of the entire Agreement shall not be affected thereby.

     5.11 Titles and Subtitles. The titles and subtitles used in this Agreement are for
convenience only and are not to be considered in construing or interpreting any term or provision
of this Agreement.

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     NOW THEREFORE, the Company and Purchasers have executed this Stock Purchase Agreement as of
the date first above written.

	 	 	 	 	 
	OPKO HEALTH, INC.

 	 
	By:  	/s/ Steven D. Rubin
 	 
	 	Name:  	Steven D. Rubin 	 
	 	Title:  	Executive Vice President-Administration 	 

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	INVESTORS

Frost Gamma Investments Trust

 	 
	By:  	/s/ Phillip Frost, M.D.
 	 
	 	Name:  	Phillip Frost, M.D. 	 
	 	Title:  	Trustee 	 
	 	Address:  	4400 Biscayne Blvd. Suite 1500, Miami. FL 33137 	 

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ANNEX A

	 	 	 	 	 	 	 	 	 	 	 	 	 
	 
	 	 	 	 	Number of Shares of	 	 	 	 
	 	Purchaser	 	 	Common Stock	 	 	Purchase Price	 
	 	Frost Gamma Investments Trust

	 	 	 	20,000,000	 	 	 	$	20,000,000	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	 
	 	 	 	 	 	 	 	 	 	 	 
	 	Total:

	 	 	 	20,000,000	 	 	 	$	20,000,000	 	 
	 

8EX-10.2

Exhibit 10.2

PROMISSORY NOTE

	 	 	 
	$3,000,000.00

	 	March 4, 2009
	 

	 	Miami, FL

     FOR VALUE RECEIVED, the undersigned, OPKO Health, Inc., a Delaware corporation with its
principal place of business at 4400 Biscayne Blvd., Miami, FL 33137 (“Maker”), promises to pay to
the order of Frost Gamma Investments Trust, with its principal place of business at 4400 Biscayne
Blvd., 15th Floor Miami, FL 33137 (“Payee”), at such place as may be designated in
writing by Payee, the principal sum of THREE MILLION DOLLARS ($3,000,000.00) (this “Note”).

     1. The principal amount of the loan evidenced hereby, together with any accrued and unpaid
interest, and any and all unpaid costs, fees and expenses accrued, shall be due and payable on May
4, 2009 (the “Maturity Date”).

     2. All amounts outstanding from time to time hereunder shall bear interest at the rate of
eleven percent (11%) per annum until such amounts are paid.

     3. This Note may be prepaid in whole or in part without penalty or premium. All payments of
principal shall be made in lawful money of the United States which shall be legal tender in payment
of all debts, public and private, at the time of payment.

     4. The Maker agrees to pay all costs of collection incurred in enforcing this Note, including
attorneys’ fees and costs at both trial and appellate levels and in any bankruptcy action. In the
event any legal proceedings are instituted in connection with, or for the enforcement of, this
Note, Payee shall be entitled to recover its costs of suit, including attorneys’ fees and costs, at
both trial and appellate levels and in any bankruptcy action.

     5. Each maker, endorser and guarantor or any person, firm or corporation becoming liable under
this Note hereby consents to any extension or renewal of this Note or any part hereof, without
notice, and agrees that they will remain liable under this Note during any extension or renewal
hereof, until the debts represented hereby are paid in full.

     6. All persons now or at any time liable for payment of this Note hereby waive presentment,
protest, notice of protest and dishonor. The Maker expressly consents to any extension or renewal,
in whole or in part, and all delays in time of payment or other performance which Payee may grant
at any time and from time to time without limitation and without any notice or further consent of
the undersigned. The remedies of Payee as provided herein shall be cumulative and concurrent and
may be pursued singularly, successively or together, at the sole discretion of Payee, and may be
exercised as often as the occasion therefor shall arise.

     7. This Note is to be governed by and construed in accordance with the applicable laws of the
State of Florida. Any action brought upon the enforcement of this Note is hereby authorized to be
instituted and prosecuted in the state and federal courts located in Dade County, Florida, at the
election of Payee.

 

 

     8. This Note may not be changed orally, but only by an agreement in writing, signed by the
party against whom enforcement of any waiver, change, modification or discharge is sought. This
Note shall not be assignable or transferable by Maker without the express written consent of Payee.

     9. No delay on the part of Payee in exercising any right or remedy hereunder shall operate as
a waiver of such right or remedy. No single or partial exercise of a right or remedy shall preclude
other or further exercise of that or any other right or remedy. The failure of Payee to insist upon
strict performance of any term of this Note, or to exercise any right or remedy hereunder, shall
not be construed as a waiver or relinquishment by the Payee for the future use of that term, right
or remedy. No waiver of any right of the Payee is effective unless in writing executed by the
Payee.

     10. The unenforceability or invalidity of any provision of this Note as to any person or
circumstances shall not render that provision or those provisions unenforceable or invalid as to
any other provisions or circumstances, and all provisions hereof, in all other respects, shall
remain valid and enforceable.

[SIGNATURES ON FOLLOWING PAGE]

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     IN WITNESS WHEREOF, the undersigned has executed this Note on the date specified below.

	 	 	 	 	 
	DATE: March 4, 2009 	MAKER:

OPKO HEALTH, INC.

 	 
	 	By:  	/s/
 	 
	 	Its:  	
 	 
	 	 	 	 
	 	 	 	 
	 

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