Document:

EX-10.4(b)

 Exhibit 10.4(b) 

FIRST AMENDMENT TO OFFICE LEASE 

This First Amendment to Office Lease (this “First Amendment”) is made and entered into by and between TEACHERS INSURANCE
AND ANNUITY ASSOCIATION OF AMERICA, for the benefit of its real estate account (“Landlord”), and SIENNA BIOPHARMACEUTICALS, INC., a Delaware corporation (“Tenant”), and shall be effective for all
purposes as of the date on which Tenant and Landlord execute this First Amendment as set forth on the signature page below (the “Effective Date”). 

W I T N E S S E T H: 

WHEREAS, Landlord and Tenant are parties to that certain Office Lease dated as of May 10, 2016 (the “Lease”), pursuant
to which Tenant leases from Landlord certain premises containing 7,002 square feet of Rentable Area designated as Suite 140 (herein referred to as the “Existing Premises”) on the first (1st) floor of the building known as Building III of the Westlake North Business Park, located at 30699 Russell Ranch Road, Westlake Village, California 91362 (the “Building”),
all as more particularly described in the Lease; and 
 WHEREAS, Landlord and Tenant desire to amend the Lease to, among other things,
expand the “Premises” (as such term is used in the Lease), and to modify certain other terms and provisions of the Lease, all as more particularly provided herein below; 

NOW, THEREFORE, pursuant to the foregoing, and in consideration of the mutual covenants and agreements contained herein and in the Lease, the
receipt and sufficiency of which are hereby acknowledged, the Lease is hereby amended as follows: 
 1. Defined Terms. All capitalized
terms used herein shall have the same meaning as defined in the Lease, unless otherwise defined in this First Amendment. 
 2. Expansion
of the Premises. Effective on and as of the Expansion Date (hereinafter defined), the “Premises” (as such term is used in the Lease) shall be expanded to include that certain 5,973 square feet of Rentable Area designated as Suite 215
on the second (2nd) floor of the Building, as further depicted on Exhibit A attached hereto and incorporated herein for all purposes (the “Expansion Premises”), for a term
that is co-terminous with the Lease Term, which is currently scheduled to expire on February 29, 2020 (the “Current Expiration Date”), upon and subject to all of the terms of the Lease,
as amended by this First Amendment. The “Expansion Date” shall mean the date that is two (2) weeks following the earlier of (i) the date that the First Amendment Improvements (hereinafter defined) being performed in the
Expansion Premises are Substantially Completed and the Expansion Premises is delivered to Tenant, or (ii) the date the First Amendment Improvements being performed in the Expansion Premises would have been Substantially Completed except for any
Tenant Delays. The terms “First Amendment Improvements” and “Substantial Completion” or “Substantially Completed” are defined in the attached Exhibit B Work Letter. “Tenant
Delays” consist of those delays defined in Exhibit B. 

 Landlord estimates that the First Amendment Improvements will be Substantially Completed on or
about August 1, 2017; provided, however, should the delivery of the Expansion Premises to Tenant be delayed for any reason whatsoever, the Lease, as herein amended, shall not be void or voidable, nor shall Landlord be liable to Tenant for any
loss or damage resulting therefrom. Notwithstanding the foregoing, in the event that the Expansion Date does not occur on or before the Outside Date (hereinafter defined), then Tenant’s sole and exclusive remedy shall be to receive from
Landlord a rent credit equal to one (1) day of free Base Rent first becoming due for the Expansion Premises only, for every day that the First Amendment Improvements are not Substantially Completed following the Outside Date. The term
“Outside Date” shall mean November 30, 2017; provided, however, the Outside Date shall be postponed (x) one (1) day for each day of Tenant Delay, (y) one (1) day for each day of Force Majeure delay and
(z) one (1) day for each day beyond June 9, 2017 that Tenant fails to execute this First Amendment. 
 Promptly following the
Expansion Date, Landlord and Tenant agree to execute a declaration specifying the Expansion Date. Landlord and Tenant hereby acknowledge and agree that, commencing on and as of the Expansion Date and continuing throughout the remainder of the Lease
Term, the “Premises” shall consist of both the Existing Premises and Expansion Premises, containing an aggregate of 12,975 square feet of Rentable Area in Suite 215 and Suite 140 in the Building. 

3. Pre-Term Access to Expansion Premises. Tenant shall have the right to access the Expansion
Premises prior to the Expansion Date, subject to and in accordance with the following terms and conditions: 
  

	 	(a)	 Pre-Term Access Period. Subject to applicable ordinances and
building codes governing Tenant’s right to occupy or perform in the Expansion Premises and subject to all of the terms and provisions of the Lease (except for the payment of Base Rent and Operating Expenses for the Expansion Premises only),
Tenant shall be allowed to access the Expansion Premises for a period of time commencing no earlier than two (2) weeks prior to the date that Landlord estimates the Substantial Completion of the First Amendment Improvements will occur and
continuing through the day immediately preceding the Pre-Term Occupancy Commencement Date, as defined below (such period, the “Pre-Term Access Period”),
for the sole purpose of installing Tenant’s furniture, fixtures, computer equipment, telephone equipment and other routine network connections in the Expansion Premises, provided that Tenant does not thereby interfere with the completion of
Landlord’s construction of the First Amendment Improvements or cause any labor dispute as a result of such installations, and provided further that Tenant does hereby agree to indemnify, defend, and hold Landlord harmless from any loss or
damage to such property, and all liability, loss, or damage arising from any injury to the Project, Building or the property of Landlord, its contractors, subcontractors, or materialmen, and any death or personal injury to any person or persons
arising out of such installations, EVEN IF SUCH LOSS, DAMAGE, 

  
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LIABILITY, DEATH, OR PERSONAL INJURY WAS CAUSED SOLELY OR IN PART BY LANDLORD’S NEGLIGENCE, BUT NOT TO THE EXTENT CAUSED BY THE GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF LANDLORD. Any such
occupancy or performance in the Expansion Premises shall be in accordance with the provisions governing Alterations in the Lease, and shall be subject to Tenant providing to Landlord satisfactory evidence of insurance for personal injury and
property damage related to such installations and satisfactory payment arrangements with respect to installations permitted hereunder. Delay in putting Tenant in possession of the Expansion Premises due to such
pre-term access shall not make Landlord liable for any damages arising therefrom, except as expressly set forth in Paragraph 2 of this First Amendment. 

 

	 	(b)	Pre-Term Occupancy Period. Commencing on the date that the First Amendment Improvements are Substantially Completed (herein referred to as the “Pre-Term Occupancy Commencement Date”) and continuing through the day immediately preceding the Expansion Date (such period, the “Pre-Term Occupancy
Period”), Tenant shall have the right to occupy the Expansion Premises for conducting business operations therefrom. During such Pre-Term Occupancy Period, all the terms of the Lease shall apply to
Tenant’s lease and occupancy of the Expansion Premises, except that no Rent shall be due for the Expansion Premises during such period. 

4. Base Rent. Tenant shall continue to pay Base Rent as follows: 

 

	 	(a)	Existing Premises. Tenant shall continue to pay Base Rent due for the Existing Premises in accordance with the existing terms and provisions of the Lease applicable thereto, including, without limitation, Item
5 of the Basic Lease Provisions of the Lease. 

  

	 	(b)	Expansion Premises. Additionally, commencing on the Expansion Date and continuing throughout the Lease Term, Tenant shall also pay Base Rent for the Expansion Premises. The Base Rent due for the Expansion
Premises for the period commencing on the Expansion Date and continuing through the Current Expiration Date shall be in the following amounts and otherwise paid by Tenant pursuant to the terms of the Lease: 

 

									
	 Period
	  	Rate/Rsf/Month
(approx.)	 	  	Monthly Installment	 
	 Expansion Date – 10/31/2017
	  	$	2.60	 	  	$	15,529.80	 
	 11/01/2017 – 10/31/2018
	  	$	2.68	 	  	$	15,995.69	 
	 11/01/2018 – 10/31/2019
	  	$	2.76	 	  	$	16,475.56	 
	 11/01/2019 – 02/29/2020
	  	$	2.84	 	  	$	16,969.83	 

  
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 Notwithstanding the foregoing, provided that Tenant is not then in default beyond applicable
notice and cure periods, the Base Rent attributable to the Expansion Premises only shall be abated for the first three (3) months following the Expansion Date (or, if the Expansion Date occurs on a day other than the first day of a calendar
month, then for the first ninety (90) days following the Expansion Date). 
 5. Additional Rent. Tenant shall continue to pay
Additional Rent due under the Lease as follows: 
  

	 	(a)	Existing Premises. Tenant shall continue to pay all Additional Rent (including, without limitation, Tenant’s Proportionate Share of Operating Expenses) due for the Existing Premises in accordance with the
existing terms and provisions of the Lease applicable thereto. 

  

	 	(b)	Expansion Premises. Additionally, commencing on the Expansion Date and continuing throughout the Lease Term, Tenant shall also pay all Additional Rent due for the Expansion Premises in accordance with the terms
and provisions of the Lease applicable thereto, except that for purposes of calculating Tenant’s Proportionate Share of Operating Expenses attributable to the Expansion Premises only, (i) Tenant’s Proportionate Share for the Expansion
Premises only shall be 4.4671% (5,973 rsf/133,711 rsf) with respect to the Building and 3.0264% (5,973 rsf/197,366 rsf) with respect to the Project, (ii) the Base Year for the Expansion Premises only shall be calendar year 2018, and
(iii) no Operating Expenses shall be due for the Expansion Premises for the period commencing on the Expansion Date and ending on the day immediately preceding the one (1) year anniversary of the Expansion Date. 

6. Condition of the Premises. Notwithstanding anything in the Lease to the contrary, Landlord has heretofore delivered the Existing
Premises to Tenant, and Tenant has accepted the Existing Premises pursuant to the terms of the Lease, and Landlord shall have no obligation whatsoever to refurbish or otherwise improve the Existing Premises at any time throughout the remainder of
the Lease Term, subject to any maintenance or repair obligation of Landlord expressly set forth in the Lease. 
 Additionally, Landlord
shall deliver the Expansion Premises to Tenant, and Tenant hereby agrees to accept the Expansion Premises from Landlord throughout the remainder of the Lease Term in its existing “AS-IS”, “WHERE-IS” and “WITH ALL FAULTS” condition (subject to any Landlord’s maintenance or repair obligations expressly set forth in the Lease), and Landlord shall have no obligation whatsoever to
refurbish or otherwise improve the 

  
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Expansion Premises at any time throughout the remainder of the Lease Term (subject to any Landlord’s maintenance or repair obligations expressly set forth in the Lease); provided, however,
Landlord agrees to provide to Tenant a tenant improvement allowance of up to $107,514.00 (which is equal to $18.00 per square foot of Rentable Area in the Expansion Premises, out of which up to $895.95 shall be available to be applied towards space
planning) (the “First Amendment Allowance”) to be applied toward the cost of performing the First Amendment Improvements in the Expansion Premises in accordance with and subject to the terms and conditions set forth in the Work
Letter attached hereto as Exhibit B. 
 Tenant acknowledges and agrees that any other obligations of Landlord originally existing in
the Lease to complete any leasehold improvements and/or furnish allowance, including, without limitation, those set forth in Exhibit B attached to the Lease, have been completed and/or satisfied in their entirety; provided, however, that
Landlord shall continue to have its existing maintenance and repair obligations as expressly set forth in the Lease. 
 7. Parking.
Tenant shall continue to have its existing parking rights and obligations in accordance with the existing terms and provisions of the Lease applicable thereto, including, without limitation, Item 13 of the Basic Lease Provisions of the
Lease. Additionally, commencing on the Expansion Date and continuing throughout the remainder of the Lease Term, Landlord shall make available to Tenant up to twenty-four (24) additional parking spaces, consisting of (i) four (4) reserved
parking spaces in the covered parking area located in the Project’s covered parking structure in the location shown on Exhibit E attached hereto (subject to relocation within the covered parking area by Landlord in the event of any
repairs, maintenance or other improvements being performed in the parking facility) and (ii) twenty (20) unreserved parking spaces in the surface parking area, all at no additional charge to Tenant through the Current Expiration Date. 

8. Letter of Credit. Within ten (10) business days following Tenant’s execution of this First Amendment, Tenant shall deliver
to Landlord a replacement Letter of Credit (the “Replacement LOC”) for the benefit of Landlord, in the principal amount of $181,211.20 (the “Replacement LOC Amount”), in the form attached to the Lease as Exhibit
F, that conforms with the terms and provisions set forth in Paragraph 2(c) of the Lease, which shall be held by Landlord subject to and in accordance with the terms and conditions set forth in said Paragraph 2(c). Provided that
there is no default under the Lease beyond any applicable notice or cure periods, within ten (10) business days of Landlord’s receipt of the Replacement LOC for the Replacement LOC Amount, Landlord shall surrender to Tenant the existing
Letter of Credit it currently has on file. 
 9. Renewal Option. Landlord and Tenant acknowledge and agree that Tenant shall continue
to have the right to further extend the Lease Term for the Premises for a period of three (3) years in accordance with and subject to the terms and conditions set forth in Addendum One attached to the Lease, except that Tenant may elect
to exercise such renewal option for (i) the Existing Premises only, (ii) the Expansion Premises only or (iii) both the Existing Premises and the Expansion Premises. 

  
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 10. Right of First Refusal. Tenant is hereby granted a right of first refusal in
accordance with and subject to the terms and conditions set forth in Exhibit C attached hereto and incorporated herein for all purposes. 

11. No Preferential Rights or Options. Except for the renewal option described in Paragraph 9 of this First Amendment and the
right of first refusal set forth in Paragraph 10 of this First Amendment and Exhibit C attached hereto, notwithstanding anything contained in the Lease or this First Amendment to the contrary, Landlord and Tenant stipulate and agree
that Tenant has no preferential rights or options under the Lease, as herein amended, such as any rights of renewal, expansion, reduction, refusal, offer, purchase, termination, relocation or any other such preferential rights or options, such
rights originally set forth in the Lease, being hereby null and void in their entirety and of no further force or effect. 
 12. Furniture
in the Expansion Premises. Tenant, in Tenant’s sole discretion and at no additional cost to Tenant, shall have the right and be entitled to use the office furniture existing in the Expansion Premises as of the Effective Date of this First
Amendment, as further described on Exhibit D attached hereto (all such existing furniture being collectively referred to herein as the “Expansion Premises Furniture”). No later than thirty (30) days after the Effective
Date of this First Amendment, Tenant shall notify Landlord in writing whether Tenant has elected to use any or all of the Expansion Premises Furniture or require Landlord, at Landlord’s sole cost and expense, to remove the Expansion Premises
Furniture or portions thereof prior to the Expansion Date. The Expansion Premises Furniture shall be delivered with the Expansion Premises in its AS-IS, WHERE-IS and
WITH ALL FAULTS condition, and Landlord hereby disclaims any and all warranties with respect to such Expansion Premises Furniture, whether express or implied (including, without limitation, any warranty of merchantability or fitness for a particular
purpose). Furthermore, Tenant hereby understands and agrees that throughout the Lease Term, Tenant shall, at Tenant’s sole cost and expense, maintain, repair and keep such Expansion Premises Furniture in good working order, normal wear and tear
excepted and Landlord shall have no obligation whatsoever to maintain, repair or replace any of such Expansion Premises Furniture, or to insure any of such Expansion Premises Furniture, and any loss or damage to such Expansion Premises Furniture
shall be at Tenant’s sole risk and Tenant hereby releases Landlord from any obligation with respect thereto. Such Expansion Premises Furniture is and shall remain the property of Landlord and Tenant shall not remove or otherwise discard, modify
and/or add to such Expansion Premises Furniture without Landlord’s prior written consent, which shall not be unreasonably withheld, delayed or conditioned. Notwithstanding the foregoing, Tenant shall have the right to move or reconfigure such
Expansion Premises Furniture within the Expansion Premises throughout the Lease Term. Upon the expiration or earlier termination of the Lease, Tenant shall surrender such Expansion Premises Furniture in the Expansion Premises in a safe, clean and
neat condition, normal wear and tear excepted. 
 13. Tenant’s Signage. Upon the Expansion Date, Landlord agrees to provide and
install Directory Board Listing and Interior Suite Signage (as such terms are defined in Paragraph 19(gg) of the Lease) for the Expansion Premises, at Landlord’s cost, and Tenant shall be responsible for the cost of all replacements or
repairs thereto. Such Directory Board Listing and Interior Suite Signage for the Expansion Premises shall be subject to the terms and conditions governing the Directory Board Listing and Interior Suite Signage for the Existing Premises set forth in
said Paragraph 19(gg). 

  
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 14. Access Cards. Upon Tenant’s written request therefor, Landlord agrees to provide
twenty-four (24) additional card-keys to Tenant in connection with the Expansion Premises, at no cost to Tenant. Tenant shall have the right to purchase from Landlord additional card-keys, at the cost that Landlord paid for same (with no mark-up). 
 15. CASp. As of the date of this First Amendment, neither the Building nor the Premises
has undergone inspection by a Certified Access Specialist (CASp). A CASp can inspect the Premises and determine whether the Premises comply with all of the applicable construction-related accessibility standards under state law. Although state
law does not require a CASp inspection of the Premises, Landlord may not prohibit Tenant from obtaining a CASp inspection of the Premises for the occupancy Tenant, if requested by Tenant. The parties shall mutually agree on the arrangements for
the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs necessary to correct violations of construction-related accessibility standards within the Premises. Except as
otherwise expressly agreed upon in writing by Landlord and Tenant, Landlord and Tenant shall have no obligation for the payment of the CASp fee or the cost of making repairs pursuant thereto (and any such cost allocation shall be pursuant to such
written agreement), nor shall Landlord have any liability to Tenant arising out of or related to the fact that neither the Premises nor the Building has been inspected by a CASp, and Tenant waives all such liability and acknowledges that Tenant
shall have no recourse against Landlord or the Building as a result of or in connection therewith. 
 16. Energy Disclosure. Tenant,
at no additional cost or charge to Tenant, shall reasonably cooperate with Landlord in furnishing any information that may be required in connection with Landlord’s obligations to furnish energy disclosures as may be required under applicable
law, including, without limitation, providing any information that may be required in order to enroll in the US Environmental Protection Agency’s Energy Star Portfolio Manager. 

17. Brokers. Tenant warrants that it has had no dealings with any broker or agent other than IDS Real Estate Group and Jones Lang
LaSalle, both representing Landlord, and Cresa Los Angeles, representing Tenant (collectively, the “Brokers”), in connection with the negotiation or execution of this First Amendment. Tenant agrees to indemnify Landlord and hold
Landlord harmless from and against any and all costs, expenses or liability for commissions or other compensations or charges claimed by any broker or agent claiming the same by, through or under Tenant, other than the Brokers, with respect to this
First Amendment. Landlord agrees to indemnify Tenant and hold Tenant harmless from and against any and all costs, expenses or liability for commissions or other compensations or charges claimed by any broker or agent claiming the same by, through or
under Landlord with respect to this First Amendment. Landlord agrees to pay the Brokers a brokerage commission pursuant to a separate written agreement. 

18. Miscellaneous. With the exception of those terms and conditions modified and amended herein, the herein referenced Lease shall
remain in full force and effect in accordance with all its terms and conditions. In the event of any conflict between the terms and provisions of this First Amendment and the terms and provisions of the Lease, the terms and provisions of this First
Amendment shall supersede and control. 

  
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 19. Counterparts/Facsimile Signatures. This First Amendment may be executed in any number
of counterparts, each of which shall be deemed an original, and all of such counterparts shall constitute one agreement. To facilitate execution of this First Amendment, the parties may execute and exchange telefaxed or e-mailed counterparts of the signature pages and such counterparts shall serve as originals. 

[SIGNATURE PAGE TO FOLLOW] 

  
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 SIGNATURE PAGE TO FIRST AMENDMENT TO LEASE 

BY AND BETWEEN 
 TEACHERS INSURANCE
AND ANNUITY ASSOCIATION OF AMERICA, AS LANDLORD, 
 AND SIENNA BIOPHARMACEUTICALS, INC., AS TENANT 

IN WITNESS WHEREOF, Landlord and Tenant, acting herein by duly authorized individuals, have caused these presents to be executed as of the
dates set forth below, to be effective for all purposes, however, as of the Effective Date set forth herein. 
  

			
	LANDLORD:
	
	TEACHERS INSURANCE AND ANNUITY ASSOCIATION OF AMERICA, for the benefit of its real estate account
		
	By:	 	 /s/ Erik Sobek

	Name:	 	Erik Sobek
	Title:	 	Senior Director
		
	Date:	 	6/13, 2017
	
	TENANT:
	
	SIENNA BIOPHARMACEUTICALS, INC., a Delaware corporation
		
	By:	 	 /s/ Frederick C. Beddingfield

	Name:	 	Frederick C. Beddingfield III, MD, PhD
	Title:	 	President and CEO
		
	Date:	 	6/6, 2017

  
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 EXHIBIT A 

EXPANSION PREMISES 
  

 

  
 A-1 

 EXHIBIT B 

WORK LETTER 
 THIS
WORK LETTER is attached as Exhibit B to the First Amendment between TEACHERS INSURANCE AND ANNUITY ASSOCIATION OF AMERICA, as Landlord, and SIENNA BIOPHARMACEUTICALS, INC., as Tenant, and constitutes the further agreement between Landlord and
Tenant as follows: 
 a) First Amendment Improvements. Landlord, at Tenant’s sole cost and expense (subject to the First
Amendment Allowance and as expressly set forth in this Work Letter), agrees to furnish or perform those items of construction and those improvements in the Expansion Premises (the “First Amendment Improvements”) specified in the
Final Plans to be agreed to by Landlord and Tenant as set forth in Paragraph (b) below; provided, however, Landlord shall pay for the cost of such First Amendment Improvements up to the extent of the First Amendment
Allowance as set forth in Paragraph (e) below. Landlord and Tenant agree that the First Amendment Improvements will include the improvements set forth on Exhibit B-1 attached
hereto. Upon the expiration or earlier termination of the Lease, Tenant shall not be obligated to remove from the Expansion Premises either (i) the First Amendment Improvements or (ii) any improvements that are currently in the Expansion
Premises as of the Effective Date of this First Amendment. 
 b) Space Planner. Landlord has retained or shall retain a space planner
or architect (the “Space Planner”) to prepare certain plans, drawings and specifications (the “Temporary Plans”) for the construction of the First Amendment Improvements to be installed in the Expansion Premises by
a general contractor selected pursuant to this Work Letter. Landlord and Tenant hereby agree that the Space Planner shall be View Design Studio (“View Design”); provided that, in the event that View Design is not available to
prepare the plans and drawings for the First Amendment Improvements as contemplated herein, or View Design’s schedule does not permit View Design to do so in a timely fashion, then Landlord may designate another architect or space planner as
the Space Planner. Tenant shall deliver to Space Planner within ten (10) days after the execution of this First Amendment, all necessary information required by the Space Planner to complete the Temporary Plans, which shall be prepared based on
the space plan approved by Landlord and Tenant and attached hereto as Exhibit B-2. Tenant shall have five (5) business days after its receipt of the proposed Temporary Plans to review the same and
notify Landlord in writing of any comments or required changes, or to otherwise give its approval or disapproval of such proposed Temporary Plans. If Tenant fails to give written comments to or approve the Temporary Plans within three (3) days
following Landlord’s written notice to Tenant of the expiration of such five (5) business day period, then Tenant shall be deemed to have approved the Temporary Plans as submitted. Landlord shall have five (5) business days following
its receipt of Tenant’s comments and objections to cause the Space Planner to redraw the proposed Temporary Plans in compliance with Tenant’s request and to resubmit the same for Tenant’s final review and approval or comment within
five (5) business days of Tenant’s receipt of such revised plans. Such process shall be repeated up to three (3) times and if at such time final approval by Tenant of the proposed Temporary Plans has not been obtained, then Landlord
shall complete such Temporary Plans, at Tenant’s sole cost and expense, and it shall be deemed that Tenant has approved the Temporary Plans. Once Tenant has approved or has been deemed to have approved the Temporary Plans, then the approved (or

  
 B-1 

 
deemed approved) Temporary Plans shall be thereafter known as the “Final Plans”. The Final Plans shall include the complete and final layout, plans and specifications for the Expansion
Premises showing all doors, light fixtures, electrical outlets, telephone outlets, wall coverings, plumbing improvements (if any), data systems wiring, floor coverings, wall coverings, painting, any other improvements to the Expansion Premises
beyond the shell and core improvements provided by Landlord and any demolition of existing improvements in the Expansion Premises. The improvements shown in the Final Plans shall (i) utilize materials and methods of construction that are
building standard or a higher quality (as mutually agreed to by Landlord and Tenant) or materials similar in quality to those found in the Existing Premises and/or Expansion Premises, (ii) be compatible with the shell and core improvements and
the design, construction and equipment of the Expansion Premises, and (iii) comply with all applicable laws, rules, regulations, codes and ordinances. 

c) Bids. As soon as practicable following the approval of the Final Plans, Landlord shall (i) obtain three (3) written non-binding itemized bids of the costs of all First Amendment Improvements shown in the Final Plans as prepared by the following three (3) general contractors which have been selected by Landlord and Tenant:
EMA Builders, Global Building Corp, Stanhope Co., and (ii) if required by applicable law, codes or ordinances, submit the Final Plans to the appropriate governmental agency for the issuance of a building permit or other required governmental
approvals prerequisite to commencement of construction of such First Amendment Improvements (“Permits”). Tenant acknowledges that any cost estimates are prepared by the general contractors and Landlord shall not be liable to Tenant
for any inaccuracy in any such estimate. Within seven (7) business days after receipt of the written non-binding cost estimates prepared by the general contractors, Tenant shall either (A) give its
written approval to the lowest general contractor bid or other bid and authorization to proceed with construction or (B) immediately request the Space Planner to modify or revise the Plans in any manner desired by Tenant to decrease the cost of
the First Amendment Improvements. If Tenant is silent during such seven (7) business day period, then Tenant shall be deemed to have approved such lowest general contractor bid. If the Final Plans are revised pursuant to Clause (B) above,
then Landlord shall request that the general contractors provide revised cost estimates to Tenant based upon the revisions to the Final Plans. Such modifications and revisions shall be subject to Landlord’s reasonable approval and shall be in
accordance with the standards set forth in Paragraph (b) of this Work Letter. Notwithstanding the foregoing, within fifteen (15) business days after receipt of the general contractors’ original written cost
estimates, Tenant shall give its final approval of the Final Plans and approval of a final bid (the “Final Approved Bid”) to Landlord which shall constitute authorization to commence the construction of the First Amendment
Improvements in accordance with the Final Plans, as modified or revised and approved by Landlord and Tenant in accordance with the terms of this Work Letter. Tenant shall signify its final approval by signing a copy of each sheet or page of the
Final Plans and delivering such signed copy to Landlord. 
 d) Construction. Landlord shall commence construction of the First
Amendment Improvements within ten (10) days following the later of (i) the approval of the Final Plans, or (ii) Landlord’s receipt of any necessary Permits. Landlord shall diligently pursue completion of construction of the First
Amendment Improvements and use its commercially reasonable efforts to complete construction of the First Amendment Improvements as soon as reasonably practicable. Subject to Paragraph (h) below, notwithstanding anything in this First
Amendment 

  
 B-2 

 
or this Work Letter to the contrary, the First Amendment Allowance, as specified in Paragraph 6 of this First Amendment, shall be used only for the construction of the First
Amendment Improvements, and if construction of the First Amendment Improvements is not completed due to any Tenant Delay within twelve (12) months following the Effective Date of this First Amendment (the “Construction Termination
Date”), then Landlord’s obligation to provide the First Amendment Allowance shall terminate and become null and void, and Tenant shall be deemed to have waived its rights in and to said First Amendment Allowance. 

Landlord shall construct the First Amendment Improvements (1) in compliance with all applicable laws, including ADA and Building codes,
and (2) in a good workmanlike manner. The Expansion Premises shall be delivered to Tenant (a) in broom clean condition, and (b) with all the Building systems servicing the Expansion Premises in good working order. 

e) First Amendment Allowance. Subject to the terms and provisions of this Work Letter, Landlord shall pay the cost of the First
Amendment Improvements (the “Work”) up to the amount of the First Amendment Allowance. If the amount of the lowest qualified bid to perform the Work exceeds the First Amendment Allowance, Tenant shall bear the cost of such excess
and shall pay the estimated cost of such excess to Landlord prior to commencement of construction of such First Amendment Improvements (the “Tenant’s Excess Payment”) and a final adjusting payment based upon the actual costs of
the First Amendment Improvements shall be made when the First Amendment Improvements are completed. If there is such an overage, then Landlord will pay the contractors from the First Amendment Allowance and the Tenant’s Excess Payment on a pro-rata basis, i.e., based on a ratio of the First Amendment Allowance to the Tenant’s Excess Payment; for illustration purposes only, if the Landlord’s allowance contribution is $15,000 and the
Tenant’s Excess Payment is $5,000, and a payment of $1,000 is due to the contractors, then such $1,000 payment shall be payable out of the Landlord’s allowance contribution and the Tenant’s Excess Payment on a 3:1 ratio, such that
$750 shall be paid from the Landlord’s allowance contribution and $250 shall be paid from the Tenant’s Excess Payment. If the cost of the Work is less than such amount, then Tenant shall not receive any credit whatsoever for the difference
between the actual cost of the Work and the First Amendment Allowance, except as expressly set forth in Paragraph (h) below. All remaining amounts due to Landlord shall be paid within ten (10) days following the earlier of
(i) Substantial Completion of the First Amendment Improvements or (ii) presentation of a written statement of the sums due hereunder, which statement may be an estimate of the cost of any component of the Work. The cost of the permits,
working drawings, hard construction costs, mechanical and electrical planning, fees, permits, general contract overhead, and a coordination fee payable to Landlord equal to two percent (2%) of the actual costs of construction and such costs or
permits, fees, planning and contractor overhead shall be payable out of the First Amendment Allowance and shall be included in the cost of the Work. The cost of the Work shall not include any other fees payable to Landlord. Tenant or the general
contractor shall not be charged for utilities and parking in connection with the construction of the First Amendment Improvements. Landlord shall engage the Space Planner, the general contractor and all other consultants (such as an engineer) or
vendors reasonably necessary for the completion of the First Amendment Improvements pursuant to the terms of this Work Letter. 

  
 B-3 

 f) Change Order. If Tenant shall desire any changes to the Final Plans, Tenant shall so
advise Landlord in writing and Landlord shall determine whether such changes can be made in a reasonable and feasible manner. Any and all costs of reviewing any requested changes, and any and all costs of making any changes to the First Amendment
Improvements which Tenant may request and which Landlord may agree to shall be at Tenant’s sole cost and expense and shall be paid to Landlord upon demand and before execution of the change order (payable out of the First Amendment Allowance to
the extent any remains available). If Landlord approves Tenant’s requested change, addition, or alteration, the Space Planner, at Tenant’s sole cost and expense (payable out of the First Amendment Allowance to the extent any remains
available), shall complete all working drawings necessary to show the change, addition or alteration being requested by Tenant. 
 g)
Substantial Completion. “Substantial Completion” (or any grammatical variant thereof) of construction of the First Amendment Improvements shall be defined as the date upon which the Space Planner or other consultant engaged
by Landlord reasonably determines that the First Amendment Improvements have been substantially completed in accordance with the Final Plans except for Punch List items (defined below), unless the completion of such improvements was delayed due to
any Tenant Delay (defined below), in which case the date of Substantial Completion shall be the date such improvements would have been completed, but for the Tenant Delays. The term “Punch List” items shall mean items that
constitute minor defects or adjustments which can be completed after occupancy without causing any material interference with Tenant’s access or use of the Expansion Premises. After the completion of the First Amendment Improvements, Tenant
shall, within ten (10) days following written demand by Landlord, execute and deliver to Landlord a letter of acceptance of the First Amendment Improvements performed on the Expansion Premises (including the notification to Landlord of any
Punch List items which shall be promptly corrected by Landlord). The term “Tenant Delay” shall include, without limitation, any delay in the completion of construction of the First Amendment Improvements resulting from
(i) Tenant’s failure to comply with the provisions of this Work Letter, (ii) any additional time as reasonably determined by Landlord required for ordering, receiving, fabricating and/or installing items or materials or other
components of the construction of the First Amendment Improvements which have been requested by Tenant and are above building standard, (iii) delay in work caused by submission by Tenant of a request for any change order following Tenant’s
approval of the Final Plans, or for the implementation of any change order, or (iv) any delay by Tenant in timely submitting comments or approvals to the Temporary Plans or Final Plans within the time periods set forth in this Work Letter. The
failure of Tenant to take possession of or to occupy the Expansion Premises following Substantial Completion and the delivery of the Expansion Premises to Tenant shall not serve to relieve Tenant of obligations arising on the Expansion Date or delay
the payment of Rent by Tenant. 
 h) Excess Allowance. Notwithstanding anything herein to the contrary, if the total cost of the Work
is less than the total amount of the First Amendment Allowance (the difference between the cost of the Work and the cost of the First Amendment Allowance being referred to herein as the “Excess Allowance”), then Landlord agrees
that, upon Tenant’s written request and subject to the further terms of this Paragraph (h), Tenant shall have the right to have up to (but not to exceed) $17,919.00 (which is $3.00 per square foot of Rentable Area in the Expansion
Premises) out of such Excess Allowance either (i) disbursed to Tenant as a reimbursement of the actual out-of-pocket expenses paid by Tenant to third parties in
connection with Tenant’s move to the Expansion Premises, including space planning and design, built-in and movable furniture, and the installation of Tenant’s signage, security system and wiring and
cabling in the Expansion 

  
 B-4 

 
Premises (the “Moving Reimbursement”), and/or (ii) credited towards the monthly installment(s) of Base Rent first becoming due for the Expansion Premises under this First
Amendment (the “Rent Credit”), until such time as the total amount of the Excess Allowance available to Tenant for such reimbursement or credit has been exhausted; provided, however, in no event shall (x) the total amount
advanced by Landlord to Tenant for the Moving Reimbursement and/or Rent Credit, exceed the lesser of the amount of the Excess Allowance or $17,919.00, and (y) the amount advanced by Landlord for the cost of the Work, the Moving Reimbursement
and/or the Rent Credit exceed the amount of the First Amendment Allowance. In the event Tenant desires any such credit and/or reimbursement, Tenant shall notify Landlord of the amounts that Tenant wants credited and/or reimbursed (and, if
reimbursed, Tenant shall include actual copies of paid invoices reflecting amounts Tenant desires to have reimbursed) on or before the Construction Termination Date, and, notwithstanding anything herein to the contrary, if Tenant fails to so notify
Landlord in writing of such amounts Tenant desires to have credited and/or reimbursed within said period, Tenant shall not be entitled to any such credit and/or reimbursement and all such Excess Allowance shall belong to Landlord and Tenant shall
have no rights thereto. 
 i) Additional Costs. Landlord, in addition to and separate from the First Amendment Allowance and in
connection with the construction of the First Amendment Improvements, shall be responsible for any costs associated with (i) the removal or encapsulation of any pre-existing Hazardous Materials (as
defined in the Lease) in the Expansion Premises that are required to be remediated by law and (ii) the removal, relocation and/or encapsulation of other tenants’ active equipment, infrastructure and/or cabling above the ceiling in the
Expansion Premises to the extent required by the construction of the First Amendment Improvements. Additionally, to the extent the restrooms in the Common Areas of the Building and the portions of the Common Areas constituting pathways of travel to
the Expansion Premises (collectively, the “ADA Compliance Areas”) are not currently in compliance with the Americans With Disabilities Act of 1990 (the “ADA”), then Landlord shall perform such code compliance work
required to the ADA Compliance Areas in order to comply with the ADA (the “ADA Work”), and the costs of such ADA Work shall be passed through as Operating Costs in accordance with Paragraph 3(d)(ii) of the Lease. Tenant shall
cause its contractors to reasonably cooperate with Landlord’s contractors in connection with such ADA Work. Notwithstanding the foregoing, to the extent any such ADA Work is required due to Tenant’s specific or unique or non-office use or otherwise due to Tenant’s intended density which is greater than the density allowed by applicable laws or codes, then Tenant shall be solely responsible for any such ADA Work required by such
specific or unique or non-office use or above-standard density. Other than as expressly set forth in this Paragraph (i), Tenant is responsible for the cost of all other code compliance work required as
a result of the First Amendment Improvements. Following the completion of such ADA Work (if any), Landlord shall have no further responsibility to perform any code compliance work in the ADA Compliance Areas or otherwise except as expressly set
forth in the Lease. Furthermore, Landlord agrees that if Tenant notifies Landlord in writing within one (1) year following the Substantial Completion of the First Amendment Improvements (the “One Year Period”) of any latent
defects in the First Amendment Improvements in the Expansion Premises discovered by Tenant (and not caused by Tenant, its employees, agents, contractors or business invitees), which materially affect the use, occupancy or aesthetic appearance of the
Expansion Premises (“Material Latent Defects”), then Landlord, at its sole expense, shall repair such Material Latent Defects within thirty (30) days after receipt of such notice from Tenant, provided that if more than thirty
(30) days is needed to adequately repair 

  
 B-5 

 
such Material Latent Defect, then as long as Landlord diligently proceeds with such repairs, Landlord shall have such additional time as is necessary to complete such repairs. Tenant covenants to
Landlord that it shall notify Landlord promptly of Tenant’s or its agents, representatives or contractor’s discovery of any Material Latent Defects in the First Amendment Improvements, and hereby agrees that it will waive any claims for
damages against Landlord due to such Material Latent Defects if Tenant does not timely and within the One Year Period notify Landlord of the same, subject to Landlord’s maintenance and repair obligations expressly set forth in the Lease. 

  
 B-6 

 EXHIBIT B-1 

LIST OF IMPROVEMENTS 
 The First
Amendment Improvements shall include the following improvements in accordance with the Space Plan (Exhibit B-2): 
  

	1.	New Armstrong VCT in Copy Room and Coffee Room. 

  

	2.	Existing carpet to remain. Steam clean as needed. 

  

	3.	New building standard paint throughout with up to two (2) accent walls (colors to be selected by Tenant). 

  

	4.	Existing ceiling grid to be in good condition – repair as needed. 

  

	5.	Window blinds to be in good working order – repair or replace as needed. 

  

	6.	Repair existing cabinets so that the doors all work/hang properly in existing Coffee Room. Replace the existing sink and faucet with new and ensure the dishwasher is in good working order. 

 

	7.	New upper and lower plastic laminate cabinetry in Copy Room 

  

	8.	Add glass sidelights to existing offices. 

  

	9.	Add glass film to existing sidelights. 

  
 B-1 – 1 

 EXHIBIT B-2 

APPROVED SPACE PLAN 
  

 

  
 B-2 – 1 

 EXHIBIT C 

RIGHT OF FIRST REFUSAL 

(a) “Offered Space” shall mean 3,312 square feet of Rentable Area designated as Suite 210 on the second (2nd) floor of the Building, as shown on Exhibit C-1 attached hereto. 

(b) Provided that as of the date of the giving of the Offer Notice (as defined below), (x) Tenant is the Tenant originally named herein or a
Successor that is an assignee pursuant to a Permitted Transfer, (y) Tenant or a Successor actually occupies at least 12,975 square feet of Rentable Area in the Building, and (z) no event of default or event beyond applicable notice
and cure periods has occurred and is continuing, if at any time during the Lease Term any portion of the Offered Space is vacant and unencumbered by any rights of any third party, and if Landlord intends to enter into a lease (the “Proposed
Lease”) for all or a portion of the Offered Space with anyone (a “Proposed Tenant”) other than the tenant then occupying such space (or its affiliates, subtenants or assignees), then Landlord shall first offer to Tenant the
right to lease such Offered Space upon all the terms and conditions of the Proposed Lease for the Offered Space. Notwithstanding anything to the contrary in the Lease, the right of first refusal granted to Tenant under this Exhibit C shall be
subject and subordinate to (i) the superior or prior rights of all tenants at the Project under existing leases, and (ii) the herein reserved right of Landlord to renew or extend the term of any lease with the tenant then occupying such
space (or any of its affiliates, subtenants or assignees), whether pursuant to a renewal or extension option in such lease or otherwise. 

(c) Such offer shall be made by Landlord to Tenant in a written notice (hereinafter called the “Offer Notice”) which offer
shall designate the space being offered and shall specify the terms for such Offered Space which shall be the same as those set forth in the Proposed Lease. Tenant agrees that the Offer Notice may be sent by Landlord concurrently with
Landlord’s delivery of any notice that Landlord is obligated to send to any tenants with superior rights to the Offered Space pursuant to the terms of the applicable existing leases. Tenant may accept the offer set forth in the Offer Notice
only by delivering to Landlord an unconditional acceptance (hereinafter called “Tenant’s Notice”) of such offer within seven (7) business days after delivery by Landlord of the Offer Notice to Tenant. Time shall be of the
essence with respect to the giving of Tenant’s Notice. If Tenant does not accept (or fails to timely accept) an offer made by Landlord pursuant to the provisions of this Exhibit C with respect to the Offered Space designated in the Offer
Notice, or if Tenant timely accepts such offer and fails to execute the ROFR Amendment (defined below) within thirty (30) days after the delivery of the Offer Notice, then Landlord shall be under no further obligation with respect to such space
by reason of this Exhibit C, except as expressly set forth in Paragraph (e) below. In order to send the Offer Notice, Landlord does not need to have negotiated a complete lease with the Proposed Tenant but may merely have agreed
upon the material economic terms for the Proposed Lease, and Tenant must make its decision with respect to the Offered Space as long as it has received a description of such material economic terms in the Offer Notice. 

  
 C-1 

 (d) Tenant must accept all Offered Space offered by Landlord at any one time if it desires to
accept any of such Offered Space and may not exercise its right with respect to only part of such space. In addition, if Landlord desires to lease more than just the Offered Space to one tenant, Landlord may offer to Tenant pursuant to the terms
hereof all such space which Landlord desires to lease, and Tenant must exercise its rights hereunder with respect to all such space and may not insist on receiving an offer for just the Offered Space. 

(e) If Tenant at any time declines any Offered Space offered by Landlord, Tenant shall be deemed to have irrevocably waived all further rights
under this Exhibit C, and Landlord shall be free to lease the Offered Space to the Proposed Tenant including on terms which may be less favorable to Landlord than those set forth in the Proposed Lease; provided, however, (i) if Landlord
has not entered into a lease for all or any portion of such Offered Space with a third party within one hundred twenty (120) days following the delivery by Landlord to Tenant of the Offer Notice, or (ii) if the terms of the Proposed Lease
become materially less favorable to Landlord than those set forth in the Offer Notice (it being understood and agreed that “materially less favorable” shall mean that the net present value of the material economic terms of the modified
transaction is at least ten percent (10%) less than the net present value of the material economic terms set forth in the Offer Notice), then, so long as Landlord is not engaged in actual lease negotiations with a third party to lease all or a
portion of such Offered Space, the right of first refusal granted to Tenant in this Exhibit C shall once again be invoked. Notwithstanding the foregoing, Tenant’s right of first refusal under this Exhibit C becomes null and void
once Landlord enters into a lease agreement for the Offered Space with a Proposed Tenant after having offered the Offered Space to Tenant as required herein. 

(f) In the event that Tenant exercises its rights to any Offered Space pursuant to this Exhibit C, then Landlord shall prepare, and
Tenant shall execute, an amendment to the Lease which confirms such expansion of the Premises and the other provisions applicable thereto, and includes all the terms and conditions set forth in the Offer Notice, and which otherwise is pursuant to
the terms of the Lease (the “ROFR Amendment”). 

  
 C-2 

 EXHIBIT C-1 

OFFERED SPACE 
  

 

  
 C-1 – 1 

 EXHIBIT D 

EXPANSION PREMISES FURNITURE 
  

									
			
	 Suite 215 furniture inventory
	  				  	 	Qty.	 
	 6-2-2017
	  				  			
			
	 Private office
	  				  			
			
	 Custom laminate top desks
	  				  	 	10	 
	 Furniture wall cabinets above desks
	  				  	 	22	 
			
	 File cabinets
	  	 	drawers	 	  	 	Qty.	 
	 Metal file cabinets –lateral
	  	 	2	 	  	 	1	 
	 Metal file cabinets –lateral
	  	 	3	 	  	 	3	 
	 ( the 3 drawer cabinets have a laminate counter top )
	  				  			
			
	 Work Stations
	  				  			
			
	 Approximate station size is 6’ X 6’ foot
	  				  	 	25	 
			
	 Desk Chairs
	  				  	 	18	 
			
	 Misc:
	  				  			
			
	 Metal 2 door cabinet 30 inches tall 36 inches wide

( these Cabinets are covered with a laminate counter top .)
	  				  	 	6	 
			
	 receptionist station
	  				  	 	1	 
			
	 Desk parts in office 217 are for office 216

( if this was put back together it would make the private office desk count 11 )
	  				  	 	1	 

  
 D-1 

 EXHIBIT E 

RESERVED PARKING LOCATIONS 
  

 

  
 E-1EX-10.5(a)

 Exhibit 10.5(a) 

SIENNA BIOPHARMACEUTICALS, INC. 

(F/K/A SIENNA LABS, INC.) 

2010 EQUITY INCENTIVE PLAN 

1.    Purposes of the Plan. The purposes of this Plan are: 

 

	 	•	 	to attract and retain the best available personnel for positions of substantial responsibility, 

  

	 	•	 	to provide additional incentive to Employees, Directors and Consultants, and 

  

	 	•	 	to promote the success of the Company’s business. 

 The Plan permits the grant of
Incentive Stock Options, Nonstatutory Stock Options, Stock Appreciation Rights, Restricted Stock and Restricted Stock Units. 

2.    Definitions. As used herein, the following definitions will apply: 

(a)    “Administrator” means the Board or any of its Committees as will be administering the Plan, in
accordance with Section 4 of the Plan. 
 (b)    “Applicable Laws” means the requirements relating
to the administration of equity-based awards under U.S. state corporate laws, U.S. federal and state securities laws, the Code, any stock exchange or quotation system on which the Common Stock is listed or quoted and the applicable laws of any
foreign country or jurisdiction where Awards are, or will be, granted under the Plan. 
 (c)    “Award”
means, individually or collectively, a grant under the Plan of Options, Stock Appreciation Rights, Restricted Stock, or Restricted Stock Units. 

(d)    “Award Agreement” means the written or electronic agreement setting forth the terms and provisions
applicable to each Award granted under the Plan. The Award Agreement is subject to the terms and conditions of the Plan. 

(e)    “Board” means the Board of Directors of the Company. 

(f)    “Change in Control” means the occurrence of any of the following events: 

(i)    Change in Ownership of the Company. A change in the ownership of the Company which occurs on the date that
any one person, or more than one person acting as a group (“Person”), acquires ownership of the stock of the Company that, together with the stock held by such Person, constitutes more than 50% of the total voting power of the stock of the
Company, except that any change in the ownership of the stock of the Company as a result of a private 

 
financing of the Company that is approved by the Board will not be considered a Change in Control; or 

(ii)    Change in Effective Control of the Company. If the Company has a class of securities registered pursuant
to Section 12 of the Exchange Act, a change in the effective control of the Company which occurs on the date that a majority of members of the Board is replaced during any twelve (12) month period by Directors whose appointment or election
is not endorsed by a majority of the members of the Board prior to the date of the appointment or election. For purposes of this clause (ii), if any Person is considered to be in effective control of the Company, the acquisition of additional
control of the Company by the same Person will not be considered a Change in Control; or 
 (iii)    Change in
Ownership of a Substantial Portion of the Company’s Assets. A change in the ownership of a substantial portion of the Company’s assets which occurs on the date that any Person acquires (or has acquired during the twelve (12) month
period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 50% of the total gross fair market value of all of the assets of the Company
immediately prior to such acquisition or acquisitions. For purposes of this subsection (iii), gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of, determined without regard to any
liabilities associated with such assets. 
 For purposes of this Section 2(f), persons will be considered to be acting as a group if they
are owners of a corporation that enters into a merger, consolidation, purchase or acquisition of stock, or similar business transaction with the Company. 

Notwithstanding the foregoing, a transaction will not be deemed a Change in Control unless the transaction qualifies as a change in control
event within the meaning of Code Section 409A, as it has been and may be amended from time to time, and any proposed or final Treasury Regulations and Internal Revenue Service guidance that has been promulgated or may be promulgated thereunder from
time to time. 
 Further and for the avoidance of doubt, a transaction will not constitute a Change in Control if: (i) its sole
purpose is to change the jurisdiction of the Company’s incorporation, or (ii) its sole purpose is to create a holding company that will be owned in substantially the same proportions by the persons who held the Company’s securities
immediately before such transaction. 
 (g)    “Code” means the Internal Revenue Code of 1986, as
amended. Any reference to a section of the Code herein will be a reference to any successor or amended section of the Code. 

(h)    “Committee” means a committee of Directors or of other individuals satisfying Applicable Laws
appointed by the Board, or by the compensation committee of the Board, in accordance with Section 4 hereof. 

(i)    “Common Stock” means the common stock of the Company. 

  
 -2- 

 (j)    “Company” means Sienna Biopharmaceuticals, Inc., a
Delaware corporation, or any successor thereto. 
 (k)    “Consultant” means any person, including an
advisor, engaged by the Company or a Parent or Subsidiary to render services to such entity. 

(l)    “Director” means a member of the Board. 

(m)    “Disability” means total and permanent disability as defined in Code Section 22(e)(3),
provided that in the case of Awards other than Incentive Stock Options, the Administrator in its discretion may determine whether a permanent and total disability exists in accordance with uniform and
non-discriminatory standards adopted by the Administrator from time to time. 

(n)    “Employee” means any person, including officers and Directors, employed by the Company or any
Parent or Subsidiary of the Company. Neither service as a Director nor payment of a director’s fee by the Company will be sufficient to constitute “employment” by the Company. 

(o)    “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(p)    “Exchange Program” means a program under which (i) outstanding Awards are surrendered or
cancelled in exchange for Awards of the same type (which may have higher or lower exercise prices and different terms), Awards of a different type, and/or cash, (ii) Participants would have the opportunity to transfer any outstanding Awards to
a financial institution or other person or entity selected by the Administrator, and/or (iii) the exercise price of an outstanding Award is reduced or increased. The Administrator will determine the terms and conditions of any Exchange Program
in its sole discretion. 
 (q)    “Fair Market Value” means, as of any date, the value of Common Stock
determined as follows: 
 (i)    If the Common Stock is listed on any established stock exchange or a national market
system, including without limitation the Nasdaq Global Select Market, the Nasdaq Global Market or the Nasdaq Capital Market of The Nasdaq Stock Market, its Fair Market Value will be the closing sales price for such stock (or the closing bid, if no
sales were reported) as quoted on such exchange or system on the day of determination, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 

(ii)    If the Common Stock is regularly quoted by a recognized securities dealer but selling prices are not reported,
the Fair Market Value of a Share will be the mean between the high bid and low asked prices for the Common Stock on the day of determination (or, if no bids and asks were reported on that date, as applicable, on the last trading date such bids and
asks were reported), as reported in The Wall Street Journal or such other source as the Administrator deems reliable; or 

(iii)    In the absence of an established market for the Common Stock, the Fair Market Value will be determined in good
faith by the Administrator. 

  
 -3- 

 (r)    “Incentive Stock Option” means an Option that by its
terms qualifies and is otherwise intended to qualify as an incentive stock option within the meaning of Code Section 422 and the regulations promulgated thereunder. 

(s)    “Nonstatutory Stock Option” means an Option that by its terms does not qualify or is not intended
to qualify as an Incentive Stock Option. 
 (t)    “Option” means a stock option granted pursuant to
the Plan. 
 (u)    “Parent” means a “parent corporation,” whether now or hereafter existing,
as defined in Code Section 424(e). 
 (v)    “Participant” means the holder of an outstanding
Award. 
 (w)    “Period of Restriction” means the period during which the transfer of Shares of
Restricted Stock are subject to restrictions and therefore, the Shares are subject to a substantial risk of forfeiture. Such restrictions may be based on the passage of time, the achievement of target levels of performance, or the occurrence of
other events as determined by the Administrator. 
 (x)    “Plan” means this 2010 Equity Incentive
Plan. 
 (y)    “Restricted Stock” means Shares issued pursuant to an Award of Restricted Stock under
Section 8 of the Plan, or issued pursuant to the early exercise of an Option. 
 (z)    “Restricted Stock
Unit” means a bookkeeping entry representing an amount equal to the Fair Market Value of one Share, granted pursuant to Section 9. Each Restricted Stock Unit represents an unfunded and unsecured obligation of the Company. 

(aa)    “Service Provider” means an Employee, Director or Consultant. 

(bb)    “Share” means a share of the Common Stock, as adjusted in accordance with Section 13 of the
Plan. 
 (cc)    “Stock Appreciation Right” means an Award, granted alone or in connection with an
Option, that pursuant to Section 7 is designated as a Stock Appreciation Right. 

(dd)    “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as
defined in Code Section 424(f). 

3.    Stock Subject to the Plan. 

(a)    Stock Subject to the Plan. Subject to the provisions of Section 13 of the Plan, the maximum aggregate
number of Shares that may be subject to Awards and sold under the Plan is 16,500,000 Shares. The Shares may be authorized but unissued, or reacquired Common Stock. 

(b)    Lapsed Awards. If an Award expires or becomes unexercisable without having been exercised in full, is
surrendered pursuant to an Exchange Program, or, with respect to Restricted Stock or Restricted Stock Units, is forfeited to or repurchased by the Company due to the 

  
 -4- 

 
failure to vest, the unpurchased Shares (or for Awards other than Options or Stock Appreciation Rights the forfeited or repurchased Shares) which were subject thereto will become available for
future grant or sale under the Plan (unless the Plan has terminated). With respect to Stock Appreciation Rights, only Shares actually issued pursuant to a Stock Appreciation Right will cease to be available under the Plan; all remaining Shares under
Stock Appreciation Rights will remain available for future grant or sale under the Plan (unless the Plan has terminated). Shares that have actually been issued under the Plan under any Award will not be returned to the Plan and will not become
available for future distribution under the Plan; provided, however, that if Shares issued pursuant to Awards of Restricted Stock or Restricted Stock Units are repurchased by the Company or are forfeited to the Company due to the failure to vest,
such Shares will become available for future grant under the Plan. Shares used to pay the exercise price of an Award or to satisfy the tax withholding obligations related to an Award will become available for future grant or sale under the Plan. To
the extent an Award under the Plan is paid out in cash rather than Shares, such cash payment will not result in reducing the number of Shares available for issuance under the Plan. Notwithstanding the foregoing and, subject to adjustment as provided
in Section 13, the maximum number of Shares that may be issued upon the exercise of Incentive Stock Options will equal the aggregate Share number stated in Section 3(a), plus, to the extent allowable under Code Section 422 and the Treasury
Regulations promulgated thereunder, any Shares that become available for issuance under the Plan pursuant to Section 3(b). 

(c)    Share Reserve. The Company, during the term of this Plan, will at all times reserve and keep available such
number of Shares as will be sufficient to satisfy the requirements of the Plan. 
 4.    Administration of the
Plan. 
 (a)    Procedure. 

(i)    Multiple Administrative Bodies. Different Committees with respect to different groups of Service Providers
may administer the Plan. 
 (ii)    Other Administration. Other than as provided above, the Plan will be
administered by (A) the Board or (B) a Committee, which Committee will be constituted to satisfy Applicable Laws. 

(b)    Powers of the Administrator. Subject to the provisions of the Plan, and in the case of a Committee, subject
to the specific duties delegated by the Board to such Committee, the Administrator will have the authority, in its discretion: 

(i)    to determine the Fair Market Value; 

(ii)    to select the Service Providers to whom Awards may be granted hereunder; 

(iii)    to determine the number of Shares to be covered by each Award granted hereunder; 

(iv)    to approve forms of Award Agreements for use under the Plan; 

  
 -5- 

 (v)    to determine the terms and conditions, not inconsistent with the
terms of the Plan, of any Award granted hereunder. Such terms and conditions include, but are not limited to, the exercise price, the time or times when Awards may be exercised (which may be based on performance criteria), any vesting acceleration
or waiver of forfeiture restrictions, and any restriction or limitation regarding any Award or the Shares relating thereto, based in each case on such factors as the Administrator will determine; 

(vi)    to institute and determine the terms and conditions of an Exchange Program; 

(vii)    to construe and interpret the terms of the Plan and Awards granted pursuant to the Plan; 

(viii)    to prescribe, amend and rescind rules and regulations relating to the Plan, including rules and regulations
relating to sub-plans established for the purpose of satisfying applicable foreign laws or for qualifying for favorable tax treatment under applicable foreign laws; 

(ix)    to modify or amend each Award (subject to Section 18(c) of the Plan), including but not limited to the
discretionary authority to extend the post-termination exercisability period of Awards and to extend the maximum term of an Option (subject to Section 6(d)); 

(x)    to allow Participants to satisfy withholding tax obligations in a manner prescribed in Section 14; 

(xi)    to authorize any person to execute on behalf of the Company any instrument required to effect the grant of an
Award previously granted by the Administrator; 
 (xii)    to allow a Participant to defer the receipt of the payment
of cash or the delivery of Shares that otherwise would be due to such Participant under an Award; and 
 (xiii)    to
make all other determinations deemed necessary or advisable for administering the Plan. 
 (c)    Effect of
Administrator’s Decision. The Administrator’s decisions, determinations and interpretations will be final and binding on all Participants and any other holders of Awards. 

5.    Eligibility. Nonstatutory Stock Options, Stock Appreciation Rights, Restricted Stock, and Restricted Stock
Units may be granted to Service Providers. Incentive Stock Options may be granted only to Employees. 
 6.    Stock
Options. 
 (a)    Grant of Options. Subject to the terms and provisions of the Plan, the Administrator, at
any time and from time to time, may grant Options in such amounts as the Administrator, in its sole discretion, will determine. 

  
 -6- 

 (b)    Option Agreement. Each Award of an Option will be evidenced by
an Award Agreement that will specify the exercise price, the term of the Option, the number of Shares subject to the Option, the exercise restrictions, if any, applicable to the Option, and such other terms and conditions as the Administrator, in
its sole discretion, will determine. 
 (c)    Limitations. Each Option will be designated in the Award Agreement
as either an Incentive Stock Option or a Nonstatutory Stock Option. Notwithstanding such designation, however, to the extent that the aggregate Fair Market Value of the Shares with respect to which Incentive Stock Options are exercisable for the
first time by the Participant during any calendar year (under all plans of the Company and any Parent or Subsidiary) exceeds one hundred thousand dollars ($100,000), such Options will be treated as Nonstatutory Stock Options. For purposes of this
Section 6(c), Incentive Stock Options will be taken into account in the order in which they were granted, the Fair Market Value of the Shares will be determined as of the time the Option with respect to such Shares is granted, and calculation will
be performed in accordance with Code Section 422 and Treasury Regulations promulgated thereunder. 
 (d)    Term
of Option. The term of each Option will be stated in the Award Agreement; provided, however, that the term will be no more than ten (10) years from the date of grant thereof. In the case of an Incentive Stock Option granted to a Participant
who, at the time the Incentive Stock Option is granted, owns stock representing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Parent or Subsidiary, the term of the Incentive Stock Option
will be five (5) years from the date of grant or such shorter term as may be provided in the Award Agreement. 

(e)    Option Exercise Price and Consideration. 

(i)    Exercise Price. The per Share exercise price for the Shares to be issued pursuant to the exercise of an
Option will be determined by the Administrator, but will be no less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. In addition, in the case of an Incentive Stock Option granted to an Employee who owns stock
representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or Subsidiary, the per Share exercise price will be no less than one hundred ten percent (110%) of the Fair Market Value per Share on
the date of grant. Notwithstanding the foregoing provisions of this Section 6(e)(i), Options may be granted with a per Share exercise price of less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant pursuant
to a transaction described in, and in a manner consistent with, Code Section 424(a). 
 (ii)    Waiting Period
and Exercise Dates. At the time an Option is granted, the Administrator will fix the period within which the Option may be exercised and will determine any conditions that must be satisfied before the Option may be exercised. 

(iii)    Form of Consideration. The Administrator will determine the acceptable form of consideration for
exercising an Option, including the method of payment. In the case of an Incentive Stock Option, the Administrator will determine the acceptable form of consideration at the time of grant. Such consideration may consist entirely of: (1) cash;
(2) check; (3) promissory note, to the extent permitted by Applicable Laws, (4) other Shares, provided that such Shares have a Fair Market Value on the date of surrender equal to the aggregate exercise price of the

  
 -7- 

 
Shares as to which such Option will be exercised and provided further that accepting such Shares will not result in any adverse accounting consequences to the Company, as the Administrator
determines in its sole discretion; (5) consideration received by the Company under cashless exercise program (whether through a broker or otherwise) implemented by the Company in connection with the Plan; (6) by net exercise, (7) such
other consideration and method of payment for the issuance of Shares to the extent permitted by Applicable Laws, or (8) any combination of the foregoing methods of payment. In making its determination as to the type of consideration to accept,
the Administrator will consider if acceptance of such consideration may be reasonably expected to benefit the Company. 

(f)    Exercise of Option. 

(i)    Procedure for Exercise; Rights as a Stockholder. Any Option granted hereunder will be exercisable according
to the terms of the Plan and at such times and under such conditions as determined by the Administrator and set forth in the Award Agreement. An Option may not be exercised for a fraction of a Share. 

An Option will be deemed exercised when the Company receives: (i) notice of exercise (in such form as the Administrator may specify from
time to time) from the person entitled to exercise the Option, and (ii) full payment for the Shares with respect to which the Option is exercised (together with applicable tax withholding). Full payment may consist of any consideration and
method of payment authorized by the Administrator and permitted by the Award Agreement and the Plan. Shares issued upon exercise of an Option will be issued in the name of the Participant or, if requested by the Participant, in the name of the
Participant and his or her spouse. Until the Shares are issued (as evidenced by the appropriate entry on the books of the Company or of a duly authorized transfer agent of the Company), no right to vote or receive dividends or any other rights as a
stockholder will exist with respect to the Shares subject to an Option, notwithstanding the exercise of the Option. The Company will issue (or cause to be issued) such Shares promptly after the Option is exercised. No adjustment will be made for a
dividend or other right for which the record date is prior to the date the Shares are issued, except as provided in Section 13 of the Plan. 

Exercising an Option in any manner will decrease the number of Shares thereafter available, both for purposes of the Plan and for sale under
the Option, by the number of Shares as to which the Option is exercised. 
 (ii)    Termination of Relationship as a
Service Provider. If a Participant ceases to be a Service Provider, other than upon the Participant’s termination as the result of the Participant’s death or Disability, the Participant may exercise his or her Option within thirty
(30) days of termination, or such longer period of time as is specified in the Award Agreement (but in no event later than the expiration of the term of such Option as set forth in the Award Agreement) to the extent that the Option is vested on
the date of termination. Unless otherwise provided by the Administrator, if on the date of termination the Participant is not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option will revert to the Plan. If
after termination the Participant does not exercise his or her Option within the time specified by the Administrator, the Option will terminate, and the Shares covered by such Option will revert to the Plan. 

  
 -8- 

 (iii)    Disability of Participant. If a Participant ceases to be a
Service Provider as a result of the Participant’s Disability, the Participant may exercise his or her Option within six (6) months of termination, or such longer period of time as is specified in the Award Agreement (but in no event later
than the expiration of the term of such Option as set forth in the Award Agreement) to the extent the Option is vested on the date of termination. Unless otherwise provided by the Administrator, if on the date of termination the Participant is not
vested as to his or her entire Option, the Shares covered by the unvested portion of the Option will revert to the Plan. If after termination the Participant does not exercise his or her Option within the time specified herein, the Option will
terminate, and the Shares covered by such Option will revert to the Plan. 
 (iv)    Death of
Participant. If a Participant dies while a Service Provider, the Option may be exercised within six (6) months following the Participant’s death, or within such longer period of time as is specified in the Award Agreement (but in no
event later than the expiration of the term of such Option as set forth in the Award Agreement) to the extent that the Option is vested on the date of death, by the Participant’s designated beneficiary, provided such beneficiary has been
designated prior to the Participant’s death in a form acceptable to the Administrator. If no such beneficiary has been designated by the Participant, then such Option may be exercised by the personal representative of the Participant’s
estate or by the person(s) to whom the Option is transferred pursuant to the Participant’s will or in accordance with the laws of descent and distribution. Unless otherwise provided by the Administrator, if at the time of death Participant is
not vested as to his or her entire Option, the Shares covered by the unvested portion of the Option will immediately revert to the Plan. If the Option is not so exercised within the time specified herein, the Option will terminate, and the Shares
covered by such Option will revert to the Plan. 
 7.    Stock Appreciation Rights. 

(a)    Grant of Stock Appreciation Rights. Subject to the terms and conditions of the Plan, a Stock Appreciation
Right may be granted to Service Providers at any time and from time to time as will be determined by the Administrator, in its sole discretion. 

(b)    Number of Shares. The Administrator will have complete discretion to determine the number of Shares subject
to any Award of Stock Appreciation Rights. 
 (c)    Exercise Price and Other Terms. The per Share exercise price
for the Shares that will determine the amount of the payment to be received upon exercise of a Stock Appreciation Right as set forth in Section 7(f) will be determined by the Administrator and will be no less than one hundred percent (100%) of the
Fair Market Value per Share on the date of grant. Otherwise, the Administrator, subject to the provisions of the Plan, will have complete discretion to determine the terms and conditions of Stock Appreciation Rights granted under the Plan. 

(d)    Stock Appreciation Right Agreement. Each Stock Appreciation Right grant will be evidenced by an Award
Agreement that will specify the exercise price, the term of the Stock Appreciation Right, the conditions of exercise, and such other terms and conditions as the Administrator, in its sole discretion, will determine. 

(e)    Expiration of Stock Appreciation Rights. A Stock Appreciation Right granted under the Plan will expire upon
the date determined by the Administrator, in its sole discretion, and 

  
 -9- 

 
set forth in the Award Agreement. Notwithstanding the foregoing, the rules of Section 6(d) relating to the maximum term and Section 6(f) relating to exercise also will apply to Stock Appreciation
Rights. 
 (f)    Payment of Stock Appreciation Right Amount. Upon exercise of a Stock Appreciation Right, a
Participant will be entitled to receive payment from the Company in an amount determined by multiplying: 
 (i)    The
difference between the Fair Market Value of a Share on the date of exercise over the exercise price; times 

(ii)    The number of Shares with respect to which the Stock Appreciation Right is exercised. 

At the discretion of the Administrator, the payment upon Stock Appreciation Right exercise may be in cash, in Shares of equivalent value, or
in some combination thereof. 
 8.    Restricted Stock. 

(a)    Grant of Restricted Stock. Subject to the terms and provisions of the Plan, the Administrator, at any time
and from time to time, may grant Shares of Restricted Stock to Service Providers in such amounts as the Administrator, in its sole discretion, will determine. 

(b)    Restricted Stock Agreement. Each Award of Restricted Stock will be evidenced by an Award Agreement that will
specify the Period of Restriction, the number of Shares granted, and such other terms and conditions as the Administrator, in its sole discretion, will determine. Unless the Administrator determines otherwise, the Company as escrow agent will hold
Shares of Restricted Stock until the restrictions on such Shares have lapsed. 
 (c)    Transferability. Except
as provided in this Section 8 or as the Administrator determines, Shares of Restricted Stock may not be sold, transferred, pledged, assigned, or otherwise alienated or hypothecated until the end of the applicable Period of Restriction. 

(d)    Other Restrictions. The Administrator, in its sole discretion, may impose such other restrictions on Shares
of Restricted Stock as it may deem advisable or appropriate. 
 (e)    Removal of Restrictions. Except as
otherwise provided in this Section 8, Shares of Restricted Stock covered by each Restricted Stock grant made under the Plan will be released from escrow as soon as practicable after the last day of the Period of Restriction or at such other
time as the Administrator may determine. The Administrator, in its discretion, may accelerate the time at which any restrictions will lapse or be removed. 

(f)    Voting Rights. During the Period of Restriction, Service Providers holding Shares of Restricted Stock
granted hereunder may exercise full voting rights with respect to those Shares, unless the Administrator determines otherwise. 

(g)    Dividends and Other Distributions. During the Period of Restriction, Service Providers holding Shares of
Restricted Stock will be entitled to receive all dividends and other 

  
 -10- 

 
distributions paid with respect to such Shares, unless the Administrator provides otherwise. If any such dividends or distributions are paid in Shares, the Shares will be subject to the same
restrictions on transferability and forfeitability as the Shares of Restricted Stock with respect to which they were paid. 

(h)    Return of Restricted Stock to Company. On the date set forth in the Award Agreement, the Restricted Stock
for which restrictions have not lapsed will revert to the Company and again will become available for grant under the Plan. 

9.    Restricted Stock Units. 

(a)    Grant. Restricted Stock Units may be granted at any time and from time to time as determined by the
Administrator. After the Administrator determines that it will grant Restricted Stock Units, it will advise the Participant in an Award Agreement of the terms, conditions, and restrictions related to the grant, including the number of Restricted
Stock Units. 
 (b)    Vesting Criteria and Other Terms. The Administrator will set vesting criteria in its
discretion, which, depending on the extent to which the criteria are met, will determine the number of Restricted Stock Units that will be paid out to the Participant. The Administrator may set vesting criteria based upon the achievement of
Company-wide, business unit, or individual goals (including, but not limited to, continued employment or service), or any other basis determined by the Administrator in its discretion. 

(c)    Earning Restricted Stock Units. Upon meeting the applicable vesting criteria, the Participant will be
entitled to receive a payout as determined by the Administrator. Notwithstanding the foregoing, at any time after the grant of Restricted Stock Units, the Administrator, in its sole discretion, may reduce or waive any vesting criteria that must be
met to receive a payout. 
 (d)    Form and Timing of Payment. Payment of earned Restricted Stock Units will be
made as soon as practicable after the date(s) determined by the Administrator and set forth in the Award Agreement. The Administrator, in its sole discretion, may settle earned Restricted Stock Units in cash, Shares, or a combination of both. 

(e)    Cancellation. On the date set forth in the Award Agreement, all unearned Restricted Stock Units will be
forfeited to the Company. 
 10.    Compliance With Code Section 409A. Awards
will be designed and operated in such a manner that they are either exempt from the application of, or comply with, the requirements of Code Section 409A, except as otherwise determined in the sole discretion of the Administrator. The Plan and
each Award Agreement under the Plan is intended to meet the requirements of Code Section 409A and will be construed and interpreted in accordance with such intent, except as otherwise determined in the sole discretion of the Administrator.
To the extent that an Award or payment, or the settlement or deferral thereof, is subject to Code Section 409A the Award will be granted, paid, settled or deferred in a manner that will meet the requirements of Code Section 409A, such that
the grant, payment, settlement or deferral will not be subject to the additional tax or interest applicable under Code Section 409A. 

  
 -11- 

 11.    Leaves of Absence/Transfer Between Locations. Unless the
Administrator provides otherwise, vesting of Awards granted hereunder will be suspended during any unpaid leave of absence. A Participant will not cease to be an Employee in the case of (i) any leave of absence approved by the Company or
(ii) transfers between locations of the Company or between the Company, its Parent, or any Subsidiary. For purposes of Incentive Stock Options, no such leave may exceed three (3) months, unless reemployment upon expiration of such leave is
guaranteed by statute or contract. If reemployment upon expiration of a leave of absence approved by the Company is not so guaranteed, then six (6) months following the first (1st) day of
such leave, any Incentive Stock Option held by the Participant will cease to be treated as an Incentive Stock Option and will be treated for tax purposes as a Nonstatutory Stock Option. 

12.    Limited Transferability of Awards. 

(a)    Unless determined otherwise by the Administrator, Awards may not be sold, pledged, assigned, hypothecated, or
otherwise transferred in any manner other than by will or by the laws of descent and distribution, and may be exercised, during the lifetime of the Participant, only by the Participant. If the Administrator makes an Award transferable, such Award
may only be transferred (i) by will, (ii) by the laws of descent and distribution, or (iii) as permitted by Rule 701 of the Securities Act of 1933, as amended (the “Securities Act”). 

(b)    Further, until the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the
Exchange Act, or after the Administrator determines that it is, will, or may no longer be relying upon the exemption from registration under the Exchange Act as set forth in Rule 12h-1(f) promulgated under the
Exchange Act, an Option, or prior to exercise, the Shares subject to the Option, may not be pledged, hypothecated or otherwise transferred or disposed of, in any manner, including by entering into any short position, any “put equivalent
position” or any “call equivalent position” (as defined in Rule 16a-1(h) and Rule 16a-1(b) of the Exchange Act, respectively), other than to
(i) persons who are “family members” (as defined in Rule 701(c)(3) of the Securities Act) through gifts or domestic relations orders, or (ii) to an executor or guardian of the Participant upon the death or disability of the
Participant. Notwithstanding the foregoing sentence, the Administrator, in its sole discretion, may determine to permit transfers to the Company or in connection with a Change in Control or other acquisition transactions involving the Company to the
extent permitted by Rule 12h-1(f). 
 13.    Adjustments; Dissolution or
Liquidation; Merger or Change in Control. 
 (a)    Adjustments. In the event that any dividend or other
distribution (whether in the form of cash, Shares, other securities, or other property), recapitalization, stock split, reverse stock split, reorganization, merger, consolidation, split-up, spin-off, combination, repurchase, or exchange of Shares or other securities of the Company, or other change in the corporate structure of the Company affecting the Shares occurs, the Administrator, in order to
prevent diminution or enlargement of the benefits or potential benefits intended to be made available under the Plan, will adjust the number and class of Shares that may be delivered under the Plan and/or the number, class, and price of Shares
covered by each outstanding Award; provided, however, that the Administrator will make such adjustments to an Award required by Section 25102(o) of the California Corporations Code to the extent the Company is relying upon the exemption afforded
thereby with respect to the Award. 

  
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 (b)    Dissolution or Liquidation. In the event of the proposed
dissolution or liquidation of the Company, the Administrator will notify each Participant as soon as practicable prior to the effective date of such proposed transaction. To the extent it has not been previously exercised, an Award will terminate
immediately prior to the consummation of such proposed action. 
 (c)    Merger or Change in Control. In the
event of a merger or Change in Control, each outstanding Award will be treated as the Administrator determines (subject to the provisions of the proceeding paragraph) without a Participant’s consent, including, without limitation, that
(i) Awards will be assumed, or substantially equivalent Awards will be substituted, by the acquiring or succeeding corporation (or an affiliate thereof) with appropriate adjustments as to the number and kind of shares and prices; (ii) upon
written notice to a Participant, that the Participant’s Awards will terminate upon or immediately prior to the consummation of such merger or Change in Control; (iii) outstanding Awards will vest and become exercisable, realizable, or
payable, or restrictions applicable to an Award will lapse, in whole or in part prior to or upon consummation of such merger or Change in Control, and, to the extent the Administrator determines, terminate upon or immediately prior to the
effectiveness of such merger or Change in Control; (iv) (A) the termination of an Award in exchange for an amount of cash and/or property, if any, equal to the amount that would have been attained upon the exercise of such Award or realization
of the Participant’s rights as of the date of the occurrence of the transaction (and, for the avoidance of doubt, if as of the date of the occurrence of the transaction the Administrator determines in good faith that no amount would have been
attained upon the exercise of such Award or realization of the Participant’s rights, then such Award may be terminated by the Company without payment), or (B) the replacement of such Award with other rights or property selected by the
Administrator in its sole discretion; or (v) any combination of the foregoing. In taking any of the actions permitted under this subsection 13(c), the Administrator will not be obligated to treat all Awards, all Awards held by a Participant, or
all Awards of the same type, similarly. 
 In the event that the successor corporation does not assume or substitute for the Award (or
portion thereof), the Participant will fully vest in and have the right to exercise all of his or her outstanding Options and Stock Appreciation Rights, including Shares as to which such Awards would not otherwise be vested or exercisable, all
restrictions on Restricted Stock and Restricted Stock Units will lapse, and, with respect to Awards with performance-based vesting, all performance goals or other vesting criteria will be deemed achieved at one hundred percent (100%) of target
levels and all other terms and conditions met. In addition, if an Option or Stock Appreciation Right is not assumed or substituted in the event of a merger or Change in Control, the Administrator will notify the Participant in writing or
electronically that the Option or Stock Appreciation Right will be exercisable for a period of time determined by the Administrator in its sole discretion, and the Option or Stock Appreciation Right will terminate upon the expiration of such period.

 For the purposes of this subsection 13(c), an Award will be considered assumed if, following the merger or Change in Control, the Award
confers the right to purchase or receive, for each Share subject to the Award immediately prior to the merger or Change in Control, the consideration (whether stock, cash, or other securities or property) received in the merger or Change in Control
by holders of Common Stock for each Share held on the effective date of the transaction (and if holders were offered a choice of consideration, the type of consideration chosen by the holders of a majority of the outstanding Shares); provided,
however, that if such consideration 

  
 -13- 

 
received in the merger or Change in Control is not solely common stock of the successor corporation or its Parent, the Administrator may, with the consent of the successor corporation, provide
for the consideration to be received upon the exercise of an Option or Stock Appreciation Right or upon the payout of a Restricted Stock Unit, for each Share subject to such Award, to be solely common stock of the successor corporation or its Parent
equal in fair market value to the per share consideration received by holders of Common Stock in the merger or Change in Control. 

Notwithstanding anything in this Section 13(c) to the contrary, an Award that vests, is earned or
paid-out upon the satisfaction of one or more performance goals will not be considered assumed if the Company or its successor modifies any of such performance goals without the Participant’s consent;
provided, however, a modification to such performance goals only to reflect the successor corporation’s post-Change in Control corporate structure will not be deemed to invalidate an otherwise valid Award assumption. 

Notwithstanding anything in this Section 13(c) to the contrary, if a payment under an Award Agreement is subject to Code Section 409A and if
the change in control definition contained in the Award Agreement does not comply with the definition of “change of control” for purposes of a distribution under Code Section 409A, then any payment of an amount that is otherwise
accelerated under this Section will be delayed until the earliest time that such payment would be permissible under Code Section 409A without triggering any penalties applicable under Code Section 409A. 

14.    Tax Withholding. 

(a)    Withholding Requirements. Prior to the delivery of any Shares or cash pursuant to an Award (or exercise
thereof), the Company will have the power and the right to deduct or withhold, or require a Participant to remit to the Company, an amount sufficient to satisfy federal, state, local, foreign or other taxes (including the Participant’s FICA
obligation) required to be withheld with respect to such Award (or exercise thereof). 
 (b)    Withholding
Arrangements. The Administrator, in its sole discretion and pursuant to such procedures as it may specify from time to time, may permit a Participant to satisfy such tax withholding obligation, in whole or in part by (without
limitation) (i) paying cash, (ii) electing to have the Company withhold otherwise deliverable Shares having a Fair Market Value equal to the minimum statutory amount required to be withheld, (iii) delivering to the Company
already-owned Shares having a Fair Market Value equal to the statutory amount required to be withheld, provided the delivery of such Shares will not result in any adverse accounting consequences, as the Administrator determines in its sole
discretion, or (iv) selling a sufficient number of Shares otherwise deliverable to the Participant through such means as the Administrator may determine in its sole discretion (whether through a broker or otherwise) equal to the amount required
to be withheld. The amount of the withholding requirement will be deemed to include any amount which the Administrator agrees may be withheld at the time the election is made, not to exceed the amount determined by using the maximum federal, state
or local marginal income tax rates applicable to the Participant with respect to the Award on the date that the amount of tax to be withheld is to be determined. The Fair Market Value of the Shares to be withheld or delivered will be determined as
of the date that the taxes are required to be withheld. 

  
 -14- 

 15.    No Effect on Employment or Service. Neither the Plan nor any
Award will confer upon a Participant any right with respect to continuing the Participant’s relationship as a Service Provider with the Company, nor will they interfere in any way with the Participant’s right or the Company’s right to
terminate such relationship at any time, with or without cause, to the extent permitted by Applicable Laws. 

16.    Date of Grant. The date of grant of an Award will be, for all purposes, the date on which the Administrator
makes the determination granting such Award, or such other later date as is determined by the Administrator. Notice of the determination will be provided to each Participant within a reasonable time after the date of such grant. 

17.    Term of Plan. Subject to Section 21 of the Plan, the Plan will become effective upon its adoption by
the Board. Unless sooner terminated under Section 18, it will continue in effect for a term of ten (10) years from the later of (a) the effective date of the Plan, or (b) the earlier of the most recent Board or stockholder
approval of an increase in the number of Shares reserved for issuance under the Plan. 
 18.    Amendment and
Termination of the Plan. 
 (a)    Amendment and Termination. The Board may at any time amend, alter, suspend
or terminate the Plan. 
 (b)    Stockholder Approval. The Company will obtain stockholder approval of any Plan
amendment to the extent necessary and desirable to comply with Applicable Laws. 
 (c)    Effect of Amendment or
Termination. No amendment, alteration, suspension or termination of the Plan will impair the rights of any Participant, unless mutually agreed otherwise between the Participant and the Administrator, which agreement must be in writing and signed
by the Participant and the Company. Termination of the Plan will not affect the Administrator’s ability to exercise the powers granted to it hereunder with respect to Awards granted under the Plan prior to the date of such termination. 

19.    Conditions Upon Issuance of Shares. 

(a)    Legal Compliance. Shares will not be issued pursuant to the exercise of an Award unless the exercise of such
Award and the issuance and delivery of such Shares will comply with Applicable Laws and will be further subject to the approval of counsel for the Company with respect to such compliance. 

(b)    Investment Representations. As a condition to the exercise of an Award, the Company may require the person
exercising such Award to represent and warrant at the time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares if, in the opinion of counsel for the
Company, such a representation is required. 
 20.    Inability to Obtain Authority. The inability of the Company
to obtain authority from any regulatory body having jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder, will relieve the Company of any

  
 -15- 

 
liability in respect of the failure to issue or sell such Shares as to which such requisite authority will not have been obtained. 

21.    Stockholder Approval. The Plan will be subject to approval by the stockholders of the Company within twelve
(12) months after the date the Plan is adopted by the Board. Such stockholder approval will be obtained in the manner and to the degree required under Applicable Laws. 

22.    Information to Participants. Beginning on the earlier of (i) the date that the aggregate number of
Participants under this Plan is five hundred (500) or more and the Company is relying on the exemption provided by Rule 12h-1(f)(1) under the Exchange Act and (ii) the date that the Company is
required to deliver information to Participants pursuant to Rule 701 under the Securities Act, and until such time as the Company becomes subject to the reporting requirements of Section 13 or 15(d) of the Exchange Act, is no longer relying on
the exemption provided by Rule 12h-1(f)(1) under the Exchange Act or is no longer required to deliver information to Participants pursuant to Rule 701 under the Securities Act, the Company shall provide to
each Participant the information described in paragraphs (e)(3), (4), and (5) of Rule 701 under the Securities Act not less frequently than every six (6) months with the financial statements being not more than 180 days old and with such
information provided either by physical or electronic delivery to the Participants or by written notice to the Participants of the availability of the information on an Internet site that may be password-protected and of any password needed to
access the information. The Company may request that Participants agree to keep the information to be provided pursuant to this section confidential. If a Participant does not agree to keep the information to be provided pursuant to this section
confidential, then the Company will not be required to provide the information unless otherwise required pursuant to Rule 12h-1(f)(1) under the Exchange Act or Rule 701 of the Securities Act. 

  
 -16-

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