Document:

EX-10.32

 Exhibit 10.32 
 CONFIDENTIAL TREATMENT 
 Amendment No. 2 to LICENSE AGREEMENT

 This Amendment No. 2 to License Agreement (this “Amendment No. 2”) is made effective the 25
day of January 2013 (the “Effective Date”) between Daiichi Sankyo Company, Limited, a Japanese Corporation having a place of business at 5-1, Nihonbashi Honcho 3-Chome, Chuo-ku, Tokyo 103-8426 Japan (“DS”), and
Omeros Corporation, a Washington corporation having a principal place of business at 1420 Fifth Avenue, Suite 2600, Seattle, WA 98101 USA (“Omeros”). 
 WHEREAS Asubio Pharma Co., Ltd. (“Asubio”) and Omeros entered into a license agreement dated February 26, 2010 (“Agreement”) under which Asubio grants Omeros an
exclusive license to certain phosphodiesterase-7 (“PDE7”) inhibitors and related patents and patent applications in the field of movement disorders [†]; 
 WHEREAS Asubio was acquired by DS on April 1, 2010, and DS succeeds all rights and obligations of Asubio under the Agreement in accordance with Section 13.9 thereof; 

WHEREAS DS and Omeros entered into an amendment No. 1 to license agreement dated January 5, 2011 (“Amendment
No. 1”) under which the parties agreed to expand the Field (as defined in the Agreement) to include certain central nervous system diseases and disorders in accordance with Section 2.3 of the Agreement; and 

WHEREAS Omeros further requests DS to expand the Field to include additional diseases and disorders in accordance with Section 2.3
of the Agreement; and 
 WHEREAS DS wishes to accept such Omeros’ request in consideration of certain payment obligations
set forth in this Amendment No. 2. 
 NOW THEREFORE, in consideration for the mutual covenants and obligations set forth
herein as well as other good and valuable consideration, the parties hereby agree as follows: 
  

	1	Definitions 

  

	1.1	Unless otherwise set forth in this Amendment No. 2, the capitalized terms herein shall have the meaning as defined in the Agreement. 

 

	1.2	“Asubio” or “Asubio Pharma Co., Ltd.” in the Agreement shall be amended to read “DS” or “Daiichi Sankyo Company, Limited”
respectively. 

  

	1.3	Section 1.7 of the Agreement is amended and restated in its entirety to read as follows: 

“ “Field” means (a) all movement disorders described in WHO ICD-10 (G20-G26) and/or in Omeros’ published
International PCT Patent Application WO 2008/119057 A2, including, without limitation, Parkinson’s Disease, Restless Legs Syndrome, Post-encephalitic Parkinsonism, Dopamine-Responsive Dystonia, Shy-Drager Syndrome, Periodic Limb Movement
Disorder, Periodic Limb Movements in Sleep, Tourette’s Syndrome, all other movement disorders treatable with a dopamine receptor agonist or a 
 † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION 

 precursor of a dopamine receptor agonist [†] (collectively “Movement Disorder
Indications”), (b) all addiction and compulsive disorders described in WHO ICD-10 (F10-F19, F40-F48, F50-F59) and/or in Omeros’ published International PCT Patent Application WO 2012/064667A2 A2 (collectively “Addiction
Indications”), and (c) all other diseases except (i) those described in above (a) and (b) and (ii) diseases in the dermatology and dermatologic affections defined as any disease of the skin, the hair/scalp and nails
(collectively “Other Indications”).” 
  

	2	Milestone Payments 

Sections 3.1 and 3.2 of the Agreement are amended and restated in their entirety to read as follows: 

 

	“3.1	Omeros shall pay DS the following one-time milestone fees (each a “Milestone Fee”) in U.S. dollars following the satisfaction of the following
corresponding milestone events (each a “Milestone”). References below in this Section 3 to a “First Indication” shall mean the initial indication among a Movement Disorder Indication, an Addiction Indication
and an Other Indication that reaches the corresponding Milestone, and “Second Indication” shall mean an indication among such three indications, excluding the one from which the First Indication was drawn, that secondly reaches the
corresponding Milestone, and “Third Indication” shall mean the last indication among such three indications, excluding the two from which the First Indication and Second Indication were drawn, that reaches the corresponding
Milestone, e.g., if the initial indication to reach a Phase 1 clinical Milestone is a Movement Disorder Indication, such Movement Disorder Indication shall trigger the First Indication Phase 1 Clinical Milestone Fee, if the indication to secondly
reach a Phase 1 clinical Milestone is an Addiction Indication, such Addiction Indication shall trigger the Second Indication Phase 1 Clinical Milestone Fee, and thereafter the Third Indication Phase 1 clinical Milestone Fee shall be triggered if and
when an Other Indication reaching a Phase 1 clinical Milestone. 

  

	3.1.1.1	Upon execution of this Agreement, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.1.2	Upon execution of the Amendment No. 1, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.1.3	Upon execution of the Amendment No. 2, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.2.1	Upon Omeros’ or its sublicensee(s)’ receipt of positive data from completed toxicology studies, each of three-months minimum duration, of a first Product in a
rodent species and in a non-rodent species, which studies have been conducted in conformance with current good laboratory practice guidance (“GLP”) promulgated by the U.S. Food and Drug Administration (“USFDA”),
which data and studies are sufficient to support the submission by Omeros or its sublicensee(s) to USFDA of an Investigational New Drug Application (“IND”) for a First Indication, Omeros shall pay DS a Milestone Fee of [†].

 † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED
SEPARATELY WITH THE COMMISSION 

	3.1.2.2	Should Omeros be required to conduct a second set of toxicology studies to support an IND for a Second Indication, then upon Omeros’ or its sublicensee(s)’
receipt of positive data from the completed second set of toxicology studies, each of three-months minimum duration, of a first Product in a rodent species and in a non-rodent species, which studies have been conducted in conformance with current
GLP promulgated by the USFDA, which data and studies are sufficient to support the submission by Omeros or its sublicensee(s) to USFDA of an IND for a Second Indication, Omeros shall pay DS a Milestone Fee of [†]. If such second set of
toxicology studies is not required, then this Milestone Fee is not payable to DS. If two sets of such toxicology studies to support an IND for a First Indication and a Second Indication, respectively, are conducted and Milestones described in
Section 3.1.2.1 and this Section 3.1.2.2 are achieved simultaneously, then Milestone Fees in Sections 3.1.2.1 and 3.1.2.2 are payable to DS. 

  

	3.1.2.3	Should Omeros be required to conduct a third set of toxicology studies to support an IND for a Third Indication, then upon Omeros’ or its sublicensee(s)’
receipt of positive data from the completed third set of toxicology studies, each of three-months minimum duration, of a first Product in a rodent species and in a non-rodent species, which studies have been conducted in conformance with current GLP
promulgated by the USFDA, which data and studies are sufficient to support the submission by Omeros or its sublicensee(s) to USFDA of an IND for a Third Indication, Omeros shall pay DS a Milestone Fee of [†]. If such third set of toxicology
studies is not required, then this Milestone Fee is not payable to DS. If three sets of such toxicology studies to support an IND for a First Indication, a Second Indication and a Third Indication, respectively, are conducted and Milestones
described in Section 3.1.2.1, Section 3.1.2.2 and this Section 3.1.2.3 are achieved simultaneously, then Milestone Fees in Sections 3.1.2.1, 3.1.2.2 and 3.1.2.3 are payable to DS. 

 

	3.1.3.1	Upon the first dosing of a human subject in the first Phase 1 clinical study for a First Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.3.2	Upon the first dosing of a human subject in the first Phase 1 clinical study for a Second Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.3.3	Upon the first dosing of a human subject in the first Phase 1 clinical study for a Third Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†] 

 † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION 

	3.1.4.1	Upon the first dosing of a human subject in the first Phase 2 clinical study for a First Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.4.2	Upon the first dosing of a human subject in the first Phase 2 clinical study for a Second Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.4.3	Upon the first dosing of a human subject in the first Phase 2 clinical study for a Third Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.5.1	Upon the first dosing of a human subject in the first Phase 3 clinical study for a First Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.5.2	Upon the first dosing of a human subject in the first Phase 3 clinical study for a Second Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.5.3	Upon the first dosing of a human subject in the first Phase 3 clinical study for a Third Indication sponsored or authorized by Omeros or its sublicensee(s) of a first
Product anywhere in the world, which study has been cleared by USFDA or a corresponding foreign regulatory agency, Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.6.1	Upon receipt of the first new drug application (“NDA”) marketing approval for a first Product for a First Indication obtained by or on behalf of Omeros
or its sublicensee(s) from USFDA, Omeros shall pay DS a Milestone Fee of [†]. 

  

	3.1.6.2	Upon receipt of the first NDA marketing approval for a first Product for a Second Indication obtained by or on behalf of Omeros or its sublicensee(s) from USFDA, Omeros
shall pay DS a Milestone Fee of [†]. 

  

	3.1.6.3	Upon receipt of the first NDA marketing approval for a first Product for a Third Indication obtained by or on behalf of Omeros or its sublicensee(s) from USFDA, Omeros
shall pay DS a Milestone Fee of [†]. 

  

	3.1.7.1	Upon receipt of the first marketing authorization for a first Product for a First Indication obtained by or on behalf of Omeros or its sublicensee(s) from an ex-U.S.
regulatory authority corresponding to USFDA, Omeros shall pay DS a Milestone Fee of [†]. 

 † DESIGNATES PORTIONS OF
THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION 

	3.1.7.2	Upon receipt of the first marketing authorization for a first Product obtained for a Second Indication by or on behalf of Omeros or its sublicensee(s) from an ex-U.S.
regulatory authority corresponding to USFDA, Omeros shall pay DS a Milestone Fee of [†]. 

  

	3.1.7.3	Upon receipt of the first marketing authorization for a first Product obtained for a Third Indication by or on behalf of Omeros or its sublicensee(s) from an ex-U.S.
regulatory authority corresponding to USFDA, Omeros shall pay DS a Milestone Fee of [†]. 

  

	3.1.8	Upon reaching an aggregate of all Net Sales of [†], Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.1.9	Upon reaching an aggregate of all Net Sales of [†], Omeros shall pay DS a Milestone Fee of [†]. 

 

	3.2	If any Milestone above is achieved with respect to a given Product for a given First, Second or Third Indication before a prior Milestone has been achieved for such
First, Second or Third Indication, the achieved milestone being the “Accelerated Milestone”, then all Milestones prior to the Accelerated Milestone for such First, Second or Third Indication that have not previously been paid with respect
to that Product shall be deemed achieved upon achievement of the Accelerated Milestone, and the corresponding payment(s) shall become payable; provided, however, that the NDA approval Milestone set forth in Subsections 3.1.6.1, 3.1.6.2 and/or
3.1.6.3 shall not be treated as a “prior Milestone” when the ex-U.S. marketing authorization Milestone set forth in Subsections 3.1.7.1, 3.1.7.2 and/or 3.1.7.3, respectively, is achieved, and the ex-U.S. marketing authorization Milestone
set forth in Subsection 3.1.7.1, Subsection 3.1.7.2 and/or 3.1.7.3 shall not be treated as a “prior Milestone” when the NDA approval Milestone set forth in Subsection 3.1.6.1, 3.1.6.2 and/or 3.1.6.3, respectively, is achieved. It is
understood by the parties that, for example, for a given Milestone, a Movement Disorder Indication could be “a given First Indication”, and for another Milestone, an Addiction Indication could be “a given First Indication”
depending on the progress of development of the first Product(s) for such indications.” 

 It is understood by the parties
that Omeros has already paid and DS has already received the Milestone Fees of [†] as provided in Section 3.1.1.1 of the Agreement and [†] as provided in Section 3.1.1.2 of the Agreement. 

 

	3	[†] 

 The following paragraphs shall
be added as Sections 2.6 and 2.7of the Agreement: 
  

	“2.6	[†] 

  

	“2.7	[†] 

 † DESIGNATES PORTIONS OF THIS
DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION 

	4	Term 

 This Amendment
No. 2 shall become effective as of the Effective Date and shall continue to be in effect as long as the Agreement is in effect. Amendment No. 1 shall be terminated on the Effective Date. 

 

	5	Miscellaneous 

  

	5.1	Section 13.11 of the Agreement is amended and restated in its entirety to read as follows: 

“Any notice required or permitted to be given under the Agreement by either party shall be in writing and shall be (a) delivered
personally, (b) sent by an internationally recognized courier service, charges prepaid, or (c) delivered by facsimile (with the original promptly sent by any of the foregoing manners) to the addresses or facsimile numbers of the other
party set forth below, or at such other addresses as may from time to time be furnished by similar notice by either party. The effective date of any notice hereunder shall be the date of receipt by the receiving party. 

 

					
	If to Omeros:	 	If to DS:
		
	 Omeros Corporation

1420 Fifth Avenue, Suite 2600
 Seattle, WA
98101
 U.S.A.
	 	 Daiichi Sankyo Company, Limited

5-1, Nihonbashi Honcho 3-Chome
 Chuo-ku, Tokyo
103-8426
 Japan

			
	Attention:	 	Gregory A. Demopulos, M.D.	 	Attention: Kazuo Sato, Ph. D.
			
		 	Chairman & CEO	 	 Corporate Officer, Vice President,
 Business Development & Licensing
 Department

			
	And copy to:	 	 Marcia S. Kelbon,

Patent & General Counsel
	 	
		
	Fax: (206) 676.5005	 	Fax: +81-3-6225-1903
	Phone: (206) 676.5000	 	Phone: +81-3-6225-1008

  

	5.2	This Amendment may be executed in one or more counterparts, each of which will be considered an original, and all of which will constitute the same instrument.

  

	5.3	Except as expressly amended by this Amendment No. 2, all terms and conditions of the Agreement shall continue to be in full force and effect.

 IN WITNESS WHEREOF, DS and Omeros have each acknowledged and accepted this Agreement by causing it to have been
signed by their respective duly authorized officials. 
 † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A
REQUEST FOR CONFIDENTIAL TREATMENT FILED SEPARATELY WITH THE COMMISSION 

									
	DAIICHI SANKYO COMPANY, LIMITED	  		 	OMEROS CORPORATION
					
	By:	  	 /s/ Kazuo Sato
	  		 	By:	  	 /s/ Gregory A. Demopulos

					
	Name:	  	Kazuo Sato, Ph. D.	  		 	Name:	  	Gregory A. Demopulos, M.D.
					
	Title:	  	 Corporate Officer, Vice President,
 Business Development & Licensing
 Department
	  		 	Title:	  	Chairman & CEO
					
	 Date:
	  	 January 21, 2013
	  		 	Date:	  	 January 25, 2013

 † DESIGNATES PORTIONS OF THIS DOCUMENT THAT HAVE BEEN OMITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT FILED
SEPARATELY WITH THE COMMISSIONEX-10.39

 Exhibit 10.39 
 CONSENT AND FIRST AMENDMENT 
 TO 

LOAN AND SECURITY AGREEMENT 
 THIS CONSENT AND FIRST AMENDMENT to Loan and Security Agreement (this “Amendment”) is entered into as of February 3, 2011, by and between OXFORD FINANCE CORPORATION
(“Lender”) and OMEROS CORPORATION, a Washington corporation (“Borrower”) whose address is 1420 5th Avenue, Suite 2600, Seattle, WA 98101. 

RECITALS 
 A. Lender and Borrower have entered into that certain Loan and Security Agreement dated as of October 21, 2010 (as the same may from time to time be further amended, modified, supplemented or
restated, the “Loan Agreement”). 
 B. Lender has extended credit to Borrower for the purposes permitted in the
Loan Agreement. 
 C. Borrower has requested that Lender consent to the creation and/or acquisition of new subsidiaries
and amend the Loan Agreement to make certain revisions to the Loan Agreement as more fully set forth herein. 
 D. Lender
has agreed to provide such consent and to so amend certain provisions of the Loan Agreement, but only to the extent, in accordance with the terms, subject to the conditions and in reliance upon the representations and warranties set forth below.

 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing recitals and other good and valuable consideration, the receipt and adequacy of which is hereby acknowledged, and
intending to be legally bound, the parties hereto agree as follows: 
 1. Definitions. Capitalized terms used but not
defined in this Amendment shall have the meanings given to them in the Loan Agreement. 
 2. Consent. 

Notwithstanding any provision of the Loan Agreement to the contrary, Lender hereby acknowledges and agrees that Borrower may create and/or
acquire the Polish Subsidiaries, provided Borrower (i) may not capitalize the Polish Subsidiaries with greater than Thirty Thousand Dollars ($30,000) (US) in the aggregate (the “Initial Capitalization”); (ii) other than
the Initial Capitalization, may not Transfer any assets to, make any other Investments in, or create or permit to be created by any Polish Subsidiary any Transfers, Liens or Indebtedness; and (iii) shall, upon the earlier of
(x) June 1, 2011 and (y) the receipt by any Polish Subsidiary of 

 
the proceeds of any grant or similar monies (including in the form of an Investment or otherwise) from the Polish government (or any other source) (collectively, the “Polish
Investment”), deliver to Lender the Polish Share Pledge and take such other actions as Lender shall reasonably request; provided further that Borrower acknowledges and agrees that in the event the Polish Investment is not received and
deployed in substantial part by June 30, 2012, Borrower shall, within 20 days’ thereof, cause the Polish Subsidiaries to be dissolved. 
 3. Amendments to Loan Agreement. 
 3.1 Section 6.1 (Government
Compliance). Clause (a) of Section 6.1 is hereby amended and restated as follows: 

“Maintain its and all its Subsidiaries’ legal existence and good standing in their respective
jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so qualify would reasonably be expected to have a Material Adverse Change. Notwithstanding the foregoing, Borrower may dissolve the Polish
Subsidiaries in accordance with the terms of the First Amendment. Borrower shall comply, and have each Subsidiary comply, with all laws, ordinances and regulations to which it is subject, noncompliance with which could have a Material Adverse
Change. 
 3.2 Section 7.3 (Mergers or Acquisitions). Section 7.3 is hereby amended by adding the following
clause (iii) after the end of clause (ii): 
 “and (iii) Borrower may acquire the Polish Subsidiaries pursuant to
the terms of the First Amendment.” 
 3.3 Section 13.1 (Definitions). 

(a) Clause (c) of the definition of “Permitted Investments” is hereby amended and restated as follows: 

“(i) Investments by Borrower in Subsidiaries (other than Non-Operating Subsidiary and the Polish Subsidiaries) not
to exceed $100,000 in the aggregate in any fiscal year, (ii) the Initial Capitalization of the Polish Subsidiaries, (iii) Investments by Borrower in any Domestic Subsidiary that has guaranteed the Obligations hereunder and
(iv) Investments by Subsidiaries in other Subsidiaries or in Borrower (in each case, other than Non-Operating Subsidiary and the Polish Subsidiaries);” 
 (b) The following defined terms are hereby added to Section 13.1 of the Loan Agreement in their appropriate alphabetical order: 

“First Amendment” means that certain Consent and First Amendment to Loan and Security Agreement, dated as
of February 3, 2011, by and between Borrower and Lender. 

  
 2 

 “Initial Capitalization” is defined in the First Amendment.

 “Polish Share Pledge” means the pledge by Borrower to Lender of one hundred percent
(100%) of the ownership interests in the Polish Subsidiaries, together with such documents and instruments as Lender deems necessary in connection therewith. 

“Polish Investment” is defined in the First Amendment. 

“Polish Subsidiaries” means no more than two (2) Subsidiaries of Borrower, organized under the laws
of Poland. 
 4. Limitation of Amendments. 
 4.1 The amendments set forth in Section 3, above, are effective for the purposes set forth herein and shall be limited precisely as written and shall not be deemed to (a) be a
consent to any amendment, waiver or modification of any other term or condition of any Loan Document, or (b) otherwise prejudice any right or remedy which Lender or any Lender may now have or may have in the future under or in connection with
any Loan Document. 
 4.2 This Amendment shall be construed in connection with and as part of the Loan Documents and all
terms, conditions, representations, warranties, covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall remain in full force and effect. 

5. Representations and Warranties. To induce Lender to enter into this Amendment, Borrower hereby represents and warrants to
Lender as follows: 
 5.1 Immediately after giving effect to this Amendment (a) the representations and warranties
contained in the Loan Documents are true, accurate and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to an earlier date, in which case they are true and correct as of such
date), and (b), except as expressly set forth above, no Event of Default has occurred and is continuing; 
 5.2 Borrower
has the power and authority to execute and deliver this Amendment and to perform its obligations under the Loan Agreement, as amended by this Amendment; 
 5.3 The organizational documents of Borrower delivered to Lender on the Effective Date remain true, accurate and complete and have not been amended, supplemented or restated and are and continue to
be in full force and effect; 

  
 3 

 5.4 The execution and delivery by Borrower of this Amendment and the performance by
Borrower of its obligations under the Loan Agreement, as amended by this Amendment, have been duly authorized; 
 5.5 The
execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting
Borrower, (b) any contractual restriction with a Person binding on Borrower, (c) any order, judgment or decree of any court or other governmental or public body or authority, or subdivision thereof, binding on Borrower, or (d) the
organizational documents of Borrower; 
 5.6 The execution and delivery by Borrower of this Amendment and the performance
by Borrower of its obligations under the Loan Agreement, as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing, recording or registration with, or exemption by any governmental
or public body or authority, or subdivision thereof, binding on either Borrower, except as already has been obtained or made or as may be required in connection with the Polish Share Pledge; and 

5.7 This Amendment has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against
Borrower in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium or other similar laws of general application and equitable principles relating to or affecting
creditors’ rights. 
 6. Counterparts. This Amendment may be executed in any number of counterparts and all of such
counterparts taken together shall be deemed to constitute one and the same instrument. 
 7. Effectiveness. This
Amendment shall be deemed effective upon the due execution and delivery to Lender of this Amendment by each party hereto, and Borrower’s payment of all Lender Expenses incurred through the date of this Amendment. 

[Balance of Page Intentionally Left Blank] 

  
 4 

 IN WITNESS WHEREOF, the parties hereto
have caused this Amendment to be duly executed and delivered as of the date first written above. 
  

									
	LENDER:	 		 	BORROWER:
			
	Oxford Finance Corporation	 		 	OMEROS CORPORATION
					
	By:	 	/s/ John G. Henderson	 		 	By:	 	/s/ Gregory A. Demopulos
	Name:	 	John G. Henderson	 		 	Name:	 	Gregory A. Demopulos, M.D.
	Title:	 	Vice President & General Counsel	 		 	Title:	 	Chairman and CEO

 [Signature Page to First Amendment to Loan and Security Agreement]

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