Document:

Secured Promissory Note

 Exhibit 10.2 
 SECURED PROMISSORY NOTE 
  

			
	US$1,000,000.00	 	October 12, 2006

 FOR VALUE RECEIVED, AVANTOGEN ONCOLOGY, INC., a Nevada corporation (“Borrower”),
promises to pay to the order of CHOPIN OPUS ONE, L.P., a Cayman Islands limited partnership (“Lender”), on December 31, 2006 (the “Maturity Date”) at Borrower’s office at 2121 Avenue of the Stars, Suite 2550, Los
Angeles, California 90067, in lawful money of the United States of America, the principal amount of One Million Dollars ($1,000,000.00) (the “Loan”), together with interest on the principal balance outstanding from the date hereof at the
rate of ten percent (10%) per annum (the “Loan Rate”) until such aggregate principal amount is paid in full. 
 Borrower may
prepay all or part of the outstanding principal amount of this Note in whole or in part at any time. 
 This Note is secured by a first
priority lien on all of Borrower’s assets (the “Collateral”) pursuant to that certain Security Agreement of even date herewith by and between Borrower and Lender (the “Security Agreement”). This Note, the Security Agreement,
the Loan Agreement of even date herewith by and between Borrower and Lender (the “Loan Agreement”), the Warrants (as defined in the Loan Agreement) and any and all other agreements presently existing or hereafter entered into which
evidence and/or secure any indebtedness from Borrower to Lender shall hereinafter be collectively referred to as the “Loan Documents”. The terms, covenants, conditions, provisions, stipulations and agreements of the Loan Documents are
hereby made a part of this Note, to the same extent and with the same effect as if they were fully set forth herein. Borrower does hereby covenant to abide by and comply with each and every term, covenant, condition, provision, stipulation and
agreement set forth in the Loan Documents. 
 Borrower shall remain liable for the payment of this Note, including interest, notwithstanding
any extensions of time of payment or any indulgence of any kind or nature that Lender may grant to Borrower, whether with or without notice to Borrower, and Borrower hereby expressly waives such notice. Lender shall not be required to look first to
the Collateral for payment of this Note but may proceed against Borrower in such manner as it deems desirable. 
 All indebtedness evidenced
by this Note shall become due and payable in full on the Maturity Date. In addition, upon the occurrence of any Event of Default (as defined in the Loan Agreement), (i) all indebtedness evidenced by this Note shall automatically become due and
payable, without presentment, demand, protest or further notice of any kind, all of which are expressly waived by Borrower, and (ii) Lender may exercise all rights and remedies available under the Security Agreement, the other Loan Documents
and applicable law. 

 Lender shall not by any act of omission or commission be deemed to waive any of its rights or remedies
hereunder unless such waiver be in writing and signed by Lender and then only to the extent specifically set forth therein. A waiver on one occasion shall not be construed as continuing or as a bar to or waiver of such right or remedy on any other
occasion. All remedies conferred upon Lender by the Loan Documents shall be cumulative and none is exclusive, and such remedies may be exercised concurrently or consecutively at Lender’s option. 
 Except as expressly provided for in this Note or any other Loan Document, Borrower waives presentment for payment, demand, notice of nonpayment of this
Note, protest and notice of protest. 
 All covenants, agreements, representations and warranties made herein and in the other Loan Documents
are deemed to have been relied upon by Lender, notwithstanding any investigation by Lender. 
 This Note is given and accepted as evidence of
indebtedness only and not in payment or satisfaction of any indebtedness or obligation. 
 The form and essential validity of this Note shall
be governed by the laws of the State of California. If any provision of this Note is prohibited by, or is unlawful or unenforceable under, any applicable law of any jurisdiction, such provision shall, as to such jurisdiction, be ineffective to the
extent of such prohibition without invalidating the remaining provisions hereof; provided that where the provisions of any such applicable law may be waived, they hereby are waived by Borrower to the full extent permitted by law in order that this
Note shall be deemed to be a valid and binding promissory note in accordance with its terms. 
 Time is of the essence with respect to all of
Borrower’s obligations and agreements under this Note and the other Loan Documents. 
 This Note and all the provisions, conditions,
promises and covenants hereof shall inure to the benefit of Lender and its successors and assigns and shall be binding in accordance with the terms hereof upon Borrower and its successors and assigns, provided nothing herein shall be deemed consent
to any assignment restricted or prohibited by the terms of the Loan Documents. 
 All notices required under this Note or any of the Loan
Documents will be in writing and will be transmitted by personal delivery, first class mail, overnight courier or facsimile to the addresses set forth in the Loan Agreement, or to such other addresses as Borrower and Lender may specify from time to
time in writing. Every notice shall be deemed to have been duly given or served on the date on which personally delivered, in person or by overnight courier service, or the date of facsimile transmission or five days after the same shall have been
deposited in the United States mail. Failure or delay in delivering copies of any notice shall in no way adversely affect the effectiveness of such notice. 
  

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 IN WITNESS WHEREOF, the undersigned has caused its duly authorized officers to execute this Note
on its behalf as of the date and year first set forth above. 
  

			
	AVANTOGEN ONCOLOGY, INC.
		
	By:	 	  
		 	 Angela Bronow Davanzo

		 	 Chief Financial Officer

 NO USURY. THIS NOTE IS HEREBY EXPRESSLY LIMITED SO THAT, IN NO EVENT WHATSOEVER, WHETHER BY REASON OF
DEFERMENT OR ADVANCEMENT OF LOAN PROCEEDS, ACCELERATION OF MATURITY OF THE LOAN EVIDENCED HEREBY OR OTHERWISE, SHALL THE AMOUNT PAID OR AGREED TO BE PAID TO LENDER HEREUNDER FOR THE LOAN, USE, FORBEARANCE OR DETENTION OF MONEY EXCEED THE MAXIMUM
INTEREST RATE PERMITTED BY THE LAWS OF THE STATE OF CALIFORNIA. IF AT ANY TIME THE PERFORMANCE OF ANY PROVISION INVOLVES A PAYMENT EXCEEDING THE LIMIT OF THE PRICE THAT MAY BE VALIDLY CHARGED FOR THE LOAN, USE, FORBEARANCE OR DETENTION OF MONEY
UNDER APPLICABLE LAW, THEN AUTOMATICALLY AND RETROACTIVELY, IPSO FACTO, THE OBLIGATION TO BE PERFORMED SHALL BE REDUCED TO SUCH LIMIT, IT BEING THE SPECIFIC INTENT OF THE LENDERS AND THE BORROWER THAT ALL PAYMENTS UNDER THIS NOTE ARE TO BE CREDITED
FIRST TO INTEREST AS PERMITTED BY LAW, BUT NOT IN EXCESS OF (i) THE AGREED RATE OF INTEREST HEREUNDER OR (ii) THAT PERMITTED BY LAW, WHICHEVER IS THE LESSER, AND THE BALANCE TOWARD THE REDUCTION OF PRINCIPAL. 
  

 - 3 -Security Agreement

 Exhibit 10.3 
 SECURITY AGREEMENT 
 SECURITY AGREEMENT dated this 12th day of October, 2006 by and between AVANTOGEN ONCOLOGY, INC., a Nevada corporation with offices at 2121 Avenue of the Stars, Suite 2550, Los Angeles,
California 90067 (the “Company”), and CHOPIN OPUS ONE, L.P., a Cayman Islands limited partnership with offices c/o Chopin Capital Partners, LLC, 2150 Avenue of the Stars, Suite 2550, Los Angeles, California 90067 (the “Secured
Party”). 
 W I T N E S S E T H 
 WHEREAS, the Secured Party has made a loan to the Company, which loan is evidenced by that certain promissory note of even date herewith given by the
Company in favor of the Secured Party (the “Note”); and 
 WHEREAS, in order to secure the Company’s obligations under the
Note, the Company is willing to grant the Secured Party a security interest in all of the assets of the Company. 
 NOW, THEREFORE, for good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 Section 1. Definitions. Except as to those terms otherwise defined in this Security Agreement, all capitalized terms used in this Security Agreement shall have the respective meanings ascribed to them in the Loan Agreement, and
all other terms which have meanings defined by the Uniform Commercial Code from time to time in effect in the State of California (the “Code”) shall have the meanings ascribed to them in the Code. 
 Section 2. The Security Interest. 
 In order to secure the payment of the Company’s obligations under the Note as the same shall become due in accordance with the provisions thereof (the “Obligations”), the Company hereby grants to the Secured Party a first
priority lien (the “Security Interest”) on all of the assets of the Company, including, but not limited to, certificates evidencing all of the shares of the common stock of Resistys, Inc., a Delaware corporation (the
“Collateral”). 
 Section 3. Filing; Further Assurances. The Company will execute, deliver, file and record, or permit
the Secured Party to file and record, any financing statements or other reproduction of a financing statement or this Security Agreement (which shall be sufficient as a financing statement hereunder), any specific assignments or other paper, and
deliver any certificated securities, that may be reasonably necessary or desirable, or that the Secured Party may reasonably request, in order to create, preserve, perfect or validate the Security Interest, or any part thereof, or to enable the
Secured Party to exercise and enforce its rights hereunder with respect to any of the Collateral. The Company hereby appoints the Secured Party as its 

 
attorney-in-fact to execute and file, in its name and on its behalf, such additional financing statements as the Secured Party may reasonably request.

 Section 4. Remedies Upon Default. In the event that the Company fails to pay any of the Obligations, the Secured Party may
exercise all the rights and remedies of a secured party under the Code. 
 Section 5. Termination of Security Interest; Release.
Upon the repayment and performance in full of the Obligations, the Security Interest shall terminate, and all rights in the Collateral shall revert to the Company. Upon any such termination of the Security Interest or release of Collateral, the
Secured Party will execute and deliver to the Company such documents as the Company shall reasonably request to evidence the termination of the Security Interest or the release of such Collateral, as the case may be, and will return to the Company
any Collateral then in the Secured Party’s possession. 
 Section 6. Waiver of Claims; Remedies. No failure or delay on the
part of the Secured Party in exercising any right, power or privilege hereunder or under any other document evidencing the Obligations and no course of dealing between the Company and the Secured Party shall operate as a waiver thereof. 

Section 7. Governing Law; Jurisdiction. This Security Agreement shall be governed by and construed in accordance with the laws of the
State of California (without giving effect to conflicts of law). The parties hereto consent to the jurisdiction of the federal or state courts sitting in the City of Los Angeles, State of California for all disputes hereunder and expressly waive any
rights they may have to contest the jurisdiction, venue or authority of such arbitrators or courts. 
 Section 8. Entire
Agreement. This Security Agreement constitutes the entire understanding between the parties with respect to the subject matter hereof, superseding all negotiations, prior discussions and preliminary agreements made prior to the date hereof.

 Section 9. Assignment. This Security Agreement shall not be assignable by any party hereto. Nothing in this Security Agreement
is intended to confer upon any person, other than the parties hereto and their successors or permitted assigns, any rights or remedies under or by any reason of this Security Agreement. 
 Section 10. Notices. All notices, consents or other communications required or permitted to be given by any party hereunder shall be in
writing (including telecopy or similar writing) and shall be given by delivery or by certified or registered mail, postage prepaid, at the addresses first above written or to such other address or telecopy number (or other similar number) as any
party may from time to time specify to the other party hereto. 
  

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 IN WITNESS WHEREOF, this Security Agreement has been executed by the parties hereto as of the day and
year first above written. 
  

			
	AVANTOGEN ONCOLOGY, INC.
		
	By:	 	  
		 	 Angela Bronow Davanzo

		 	 Chief Financial Officer

	
	CHOPIN OPUS ONE, L.P.
		
	By:	 	Chopin Holdings, Ltd., Its General Partner
	By:	 	Greenland Ltd., Its Director
		
	By:	 	  
		 	 Angelo M. Venardos

		 	 Authorized Signatory

  

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