Document:

Exhibit 10.3

 

Execution Version

 

FORM OF STOCKHOLDER SUPPORT AGREEMENT

 

THIS STOCKHOLDER SUPPORT
AGREEMENT (this “Support Agreement”) is made and entered into as of October 20, 2020, by and between
Panacea Acquisition Corp., a Delaware corporation (“Purchaser”), and the individual person or entity identified
on the signature page hereto (“Securityholder”).

 

Recitals

 

WHEREAS, Purchaser,
Panacea Merger Subsidiary Corp., a Delaware corporation and a direct, wholly owned subsidiary of Purchaser (“Merger Sub”)
and Nuvation Bio Inc., a Delaware corporation (the “Company”) have entered into an Agreement and Plan of Merger
as of October 20, 2020 (the “Merger Agreement”), which provides (upon the terms and subject to the conditions
set forth therein) for a business combination transaction by which Merger Sub will merge with and into the Company (the “Merger”),
with the Company being the surviving entity of the Merger (the Company, in its capacity as the surviving corporation of the Merger,
is sometimes referred to as the “Surviving Corporation”).

 

WHEREAS, in connection
with the Merger, upon the terms and subject to the conditions of the Merger Agreement, all shares of each class and series of Company
Common Stock and Company Preferred Stock (collectively, “Company Capital Stock”) and each option to purchase
Company Common Stock (each, a “Company Option”) will be converted into the right to receive the consideration
set forth in Section 3.1 of the Merger Agreement.

 

NOW, THEREFORE, in
consideration of the covenants, promises and representations set forth herein, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, agree as follows:

 

Agreement

 

Section
1. Certain Definitions

 

For purposes of this Support Agreement:

 

(a) Capitalized
terms used but not otherwise defined in this Support Agreement have the meanings assigned to such terms in the Merger Agreement.

 

(b) “Action”
means any legal action, suit, claim, investigation, hearing or proceeding, including any audit, claim or assessment for Taxes
or otherwise, by or before any Authority.

 

(c) “Associated
Parties” shall mean (i) Securityholder’s predecessors, successors, executors, administrators, trusts, spouse, heirs
and estate; (ii) Securityholder’s past, present and future assigns; (iii) each entity that Securityholder has the
power to bind (by Securityholder’s acts or signature) or over which Securityholder directly or indirectly exercises control;
and (iv) each entity of which Securityholder owns, directly or indirectly, at least a majority of the outstanding equity, beneficial,
proprietary, ownership or voting interests.

 

(d) “Authority”
means any governmental, quasi-governmental, regulatory or administrative body, agency, instrumentality, department or authority,
any court, tribunal, judicial authority, administrative hearing body, arbitrator, commission or other similar dispute-resolving
panel or body, or any public, private or industry regulatory authority, whether international, national, Federal, state, or local.

 

     

     

    

 

(e) “Business
Day” means any day other than a Saturday, Sunday or a legal holiday on which commercial banking institutions in Wilmington,
Delaware, New York, New York, or San Francisco, California are authorized to close for business.

 

(f) 
“Consent” shall mean any consent, approval, authorization, permit or notice.

 

(g) “Expiration
Date” shall mean the earliest of: (i) the date on which the Merger Agreement is validly terminated in accordance with
its terms or (ii) the time the Merger becomes effective (the “Effective Time”).

 

(h) “Law”
means any domestic or foreign, federal, state, municipality or local law, statute, ordinance, code, rule, regulation, legislation,
principle of common law, edict, decree, treaty, or Order that is or has been issued, enacted, adopted, passed, approved, promulgated,
made, implemented or otherwise put into effect by or under the authority of any Authority.

 

(i) “Liens”
means, with respect to any property or asset, any mortgages, liens, pledges, charges, security interests or encumbrances of any
kind in respect of such property or asset, and any conditional sale or voting agreements or proxies, including any agreements to
give any of the foregoing.

 

(j) “Order”
means any decree, order, judgment, writ, award, injunction, rule or consent of or by an Authority.

 

(k) “Person”
means an individual, corporation, partnership (including a general partnership, limited partnership or limited liability partnership),
limited liability company, association, trust or other entity or organization, including a government, domestic or foreign, or
political subdivision thereof, or an agency or instrumentality thereof.

 

(l) “Representatives”
means, collectively, with respect to any Person, such Person’s officers, directors, Affiliates, employees, agents or advisors,
including any investment banker, broker, attorney, accountant, consultant or other authorized representative of such Person.

 

(m) “Voting
Period” shall mean the period commencing on (and including) the date of this Support Agreement and ending on (and including)
the Expiration Date.

 

Section
2. Support

 

2.1 Transfer
of Securities. Securityholder agrees not to, directly or indirectly, at any time during
the Voting Period, other than as may be required by a court Order or other Law, (a) sell, assign, transfer (including by operation
of law), pledge, dispose of or otherwise encumber or otherwise agree to do any of the foregoing (each, a “Transfer”)
with respect to any of the Subject Securities, (b) deposit any Subject Securities into a voting trust or enter into a voting agreement
or arrangement or grant any proxy or power of attorney with respect thereto that is inconsistent with this Support Agreement, (c)
enter into any Contract, option or other arrangement or undertaking with respect to the direct or indirect sale, assignment, transfer
(including by operation of law) or other disposition by Securityholder of any Subject Securities, or (d) take any action that would
make any representation or warranty of Securityholder herein untrue or incorrect in any material respect or have the effect of
preventing or disabling Securityholder from performing Securityholder’s obligations hereunder; provided, that (i)
if a Securityholder is an individual, Securityholder may Transfer any such Subject Securities (A) to any member of such Securityholder’s
immediate family, or to a trust for the benefit of Securityholder or any member of such Securityholder’s immediate family,
the sole trustees of which are Securityholder or any member of Securityholder’s immediate family or (B) by will, other testamentary
document or under the laws of intestacy upon the death of such Securityholder; or (ii) if a Securityholder is an entity, Securityholder
may Transfer any Subject Securities to any partner, member, or affiliate of Securityholder; provided further, that in each
case such transferee of such Subject Securities evidences in a writing such transferee’s agreement to be bound by and subject
to the terms and provisions hereof to the same effect as such transferring Securityholder. Any Transfer or attempted Transfer of
any Subject Securities in violation of any provision of this Support Agreement shall be void ab initio and of no force or effect.

 

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2.2 Voting
Covenant. Securityholder hereby agrees that, during the Voting Period, at any meeting
of the holders of Company Capital Stock (the “Equityholders”) (whether annual or special and whether or not
adjourned or postponed), however called, and in any action by written consent of the Equityholders, at which the Merger Agreement
and other related agreements (or any amended versions thereof) or such other related actions, are submitted for the consideration
and vote of the Company Capital Stock, unless otherwise directed in writing by Purchaser, Securityholder shall cause the Subject
Securities to be voted:

 

(a) in
favor of (i) the Merger and the adoption and approval of the Merger Agreement and the terms thereof, (ii) each of the other actions
contemplated by the Merger Agreement and (iii) any action in furtherance of any of the foregoing;

 

(b) against
any action, proposal, agreement or transaction that, to the knowledge of Securityholder, would reasonably be expected to result
in a material breach of any representation, warranty, covenant or obligation of the Company in the Merger Agreement; and

 

(c) against
the following actions (other than pursuant to, or in furtherance of, the Merger and the other Transactions (as defined in the Merger
Agreement), including the Pre-Closing Recapitalization): (i) any extraordinary corporate transaction, such as a merger, consolidation
or other business combination involving the Company; (ii) any Acquisition Proposal (as defined in the Merger Agreement), including
any reorganization, recapitalization, dissolution or liquidation of the Company; (iii) any change in a majority of the board of
directors of the Company; (iv) any amendment to the Company’s Governing Documents; (iv) any change in the capitalization
of the Company or the Company’s corporate structure (other than as contemplated in or permitted by the Merger Agreement);
and (v) any other action, proposal, agreement or transaction or proposed transaction (including any possible Acquisition Proposal)
which is intended, or would reasonably be expected, to impede, interfere with, delay, postpone, discourage or adversely affect
the Merger or any of the other Transactions;

 

provided,
however, such Securityholder shall not vote or provide consent with respect to any of its Subject Securities that are not
held by the Company’s directors, officers, affiliates or greater than 5% shareholders of the Company, or take any other action,
in each case to the extent any such vote, consent or other action would preclude Purchaser from filing with the SEC a registration
statement on Form S-4 as contemplated by the Merger Agreement; provided, further, that as of the effective
date of the Merger, no amendment, modification or waiver of the Merger Agreement shall have occurred that would reasonably be expected
to adversely affect the economic benefits that Securityholder would reasonably expect to receive pursuant to the Merger.

 

Notwithstanding anything
to the contrary in this Section 2.2, (i) this Section 2.2 shall not apply to any proposal submitted to any of the
Equityholders holding the number of shares of Company Capital Stock required by the terms of Section 280G(b)(5)(B) of the Code,
whether at a meeting or in an action by written consent, to render the parachute payment provisions of Section 280G inapplicable
to any and all payments or benefits provided pursuant to Plan or other Company Contracts that might result, separately or in the
aggregate, in the payment of any amount or the provision of any benefit that would not be deductible by reason of Section 280G
or that would be subject to an excise tax under Section 4999 of the Code.

 

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2.3 Other
Voting Agreements. During the Voting Period, Securityholder shall not enter into any agreement
or understanding with any Person to vote or give instructions in any manner inconsistent with Section 2.2.

 

Section
3. Binding Terms of Merger Agreement

 

Securityholder hereby
agrees to be bound by, observe and comply with the following terms and provisions of the Merger Agreement: Article II (The Merger),
Sections 3.2 (Exchange of Certificates) (including the requirement, if Securityholder holds any Certificates, to provide a Letter
of Transmittal in accordance with Section 3.2(b) in order to be entitled to any portion of the Per Share Merger Consideration),
11.13 (Waiver), and 11.14 (Non-Recourse), as if Securityholder were an original signatory to the Merger Agreement with respect
to such provisions; provided, however, that as of the effective date of the Merger, no amendment, modification or
waiver of the Merger Agreement shall have occurred that would reasonably be expected to adversely affect the economic benefits
that Securityholder would reasonably expect to receive pursuant to the Merger.

 

Section
4.  Waiver of Appraisal Rights

 

Securityholder hereby
irrevocably and unconditionally waives, and agrees to cause to be waived and to prevent the exercise of, any rights of appraisal,
any dissenters’ rights and any similar rights (including any notice requirements related thereto) relating to the Merger
that Securityholder or any other Person may have by virtue of, or with respect to, any shares of Company Capital Stock owned by
Securityholder (including all rights under Section 262 of the DGCL).

 

Section
5. Representations and Warranties of Securityholder

 

Securityholder hereby represents and warrants
to Purchaser as follows:

 

5.1 Authorization,
etc. Securityholder has the power, authority and capacity to execute and deliver this
Support Agreement and to perform Securityholder’s obligations hereunder. This Support Agreement has been duly executed and
delivered by Securityholder and constitutes a legal, valid and binding obligation of Securityholder, enforceable against Securityholder
in accordance with its terms, subject only to: (a) laws of general application relating to bankruptcy, insolvency and the relief
of debtors; and (b) rules of law governing specific performance, injunctive relief and other equitable remedies. To the extent
that Securityholder is a natural person who is married and is a resident in a community property state, Securityholder represents
and warrants that Securityholder has the absolute and unrestricted power, authority and capacity to execute and deliver this Support
Agreement and to perform Securityholder’s obligations hereunder, notwithstanding any laws related to community property.
To the extent that Securityholder is not a natural person, including if Securityholder is a trust, Securityholder hereby further
represents and warrants that: (i) Securityholder is duly organized, validly existing and in good standing under the laws of the
jurisdiction in which it was organized; (ii) Securityholder has the power to execute, deliver and perform this Support Agreement
and the undersigned has the power to execute and deliver this Support Agreement on behalf of Securityholder; (iii) Securityholder
has taken all necessary action to authorize the execution, delivery and performance of this Support Agreement; and (iv) the execution,
delivery and performance of this Support Agreement by Securityholder will not violate any provision of Securityholder’s Governing
Documents. Securityholder has read and understood this Support Agreement, including the waiver of jury trial contained herein,
has consulted, or had the opportunity to consult, with Securityholder’s legal counsel or other advisors with respect thereto,
has knowingly and voluntarily elected to sign and accept this Support Agreement, and has not relied upon any promise, statement,
or representation that is not set forth explicitly herein in deciding to sign and accept this Support Agreement.

 

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5.2 No
Conflicts or Consents.

 

(a) The
execution and delivery of this Support Agreement by Securityholder does not, and the performance of this Support Agreement by Securityholder
will not: (i) conflict with or violate any Law or Order applicable to Securityholder or by which Securityholder or any of Securityholder’s
assets is or may be bound or affected; or (ii) result in or constitute (with or without notice or lapse of time) any breach of
or default under, or give to any other Person (with or without notice or lapse of time) any right of termination, amendment, acceleration
or cancellation of, or result (with or without notice or lapse of time) in the creation of any Lien on any of the securities of
the Company owned by Securityholder pursuant to, any Contract to which Securityholder is a party or by which Securityholder or
any of Securityholder’s assets is or may be bound or affected except, in the case of clause (i) or (ii), as would not reasonably
be expected, either individually or in the aggregate, to materially impair the ability of Securityholder to perform its obligations
hereunder or to consummate the transactions contemplated hereby.

 

(b) With
the exception of any notification or approval that the Company or Securityholder is required to provide under the terms of any
applicable Laws, the execution and delivery of this Support Agreement by Securityholder does not, and the performance of this Support
Agreement by Securityholder will not, require any Consent of any Person.

 

(c) There
is no Action by or before any Governmental Entity pending or, to the best of the knowledge of Securityholder, threatened against
Securityholder or any of its Associated Parties that challenges or would challenge the execution and delivery of this Support Agreement
or the taking of any of the actions required to be taken by Securityholder under this Support Agreement.

 

5.3 Title
to Securities. As of the date of this Support Agreement: (a) Securityholder has good and
valid title to and holds of record (free and clear of any Liens other than those arising under applicable securities laws or as
would not otherwise restrict the performance of Securityholder’s obligations pursuant to this Support Agreement) the number,
class and series of shares of Company Capital Stock set forth under the headings “Class of Shares Held of Record” and
“Number of Shares Held of Record” on the signature page hereof; (b) Securityholder holds (free and clear of any
Liens) the options and other rights to acquire shares of Company Capital Stock set forth on the signature page hereof; (c) Securityholder
has a right and an obligation to acquire (free and clear of any Liens other than those arising under applicable securities laws
or as would not otherwise restrict the performance of Securityholder’s obligations pursuant to this Support Agreement) the
number, class and series of shares of Company Capital Stock, if any, set forth under the headings “Class of Shares To Be
Acquired” and “Additional Number of Shares To Be Acquired” on the signature page hereof; and (d) Securityholder
does not own any shares of Company Capital Stock or other securities of the Company, or any option, warrant, convertible note,
outstanding agreement or other right to acquire (by purchase, conversion or otherwise) any shares of Company Capital Stock or other
securities of the Company, other than as set forth on the signature page hereof (such securities set forth under the headings “Class
of Shares Held of Record” and “Number of Shares Held of Record”, “Class of Shares To Be Acquired”
and “Additional Number of Shares To Be Acquired”, “Company Options Held of Record” and “Number and
Type of Other Rights Held of Record” and all additional securities of the Company (including any securities convertible into
or exchangeable or exercisable for securities of the Company) of which Securityholder acquires ownership of record or the power
to vote during the Voting Period, and all other securities issued in any distribution in respect of any of the foregoing with respect
to which the Securityholder has the power to vote, the “Subject Securities”).

 

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Section
6. Alternative Acquisition Proposals.
From the date hereof until the Expiration Date, Securityholder agrees that such Person shall not, and shall not authorize or permit
its Representatives to, directly or indirectly, (i) solicit, initiate or knowingly encourage, support, facilitate or induce the
making, submission or public announcement of any inquiry, indication of interest, proposal or offer that constitutes, or could
reasonably be expected to lead to, an Acquisition Proposal, (ii) enter into, participate in, maintain or continue any communications
(except solely to provide written notice as to the existence of these provisions) or negotiations regarding, or deliver or make
available to any Person any non-public information with respect to, or knowingly take any other action regarding, any inquiry,
indication of interest, proposal or offer that constitutes, or could reasonably be expected to lead to, an Acquisition Proposal,
(iii) enter into any agreement in principle, letter of intent, term sheet or any other agreement, understanding or contract (whether
binding or not) contemplating or otherwise relating to any Acquisition Proposal, (iv) agree to, accept, approve, endorse or recommend
(or publicly propose or announce any intention or desire to agree to, accept, approve, endorse or recommend) any Acquisition Proposal,
(v) withhold, withdraw, qualify, amend or modify (or publicly propose or announce any intention or desire to withhold,
withdraw, qualify, amend or modify), in a manner adverse to the Purchaser, the approval of Securityholder’s board of directors
(if any) of this Agreement or (vi) resolve, propose or agree to do any of the following. In addition,
Securityholder shall, and shall cause its subsidiaries (if applicable) to, and each shall cause their respective Representatives
to, immediately cease any and all existing discussions or negotiations with any Person conducted prior to or on the date of this
Agreement with respect to any Acquisition Proposal. Securityholder agrees that such Person shall promptly inform such Person’s
Representatives of the obligations undertaken in this ‎Section 6.

 

Section
7. Miscellaneous.

 

7.1 Termination.
The obligations of Securityholder under this Support Agreement (other than the provisions of this Section 7) shall terminate
and be of no further force or effect upon the termination of the Merger Agreement prior to the Closing in accordance with its terms.
Nothing in this Section 7.1 shall relieve any party of liability for any willful and material breach of this Support Agreement.

 

7.2 Further
Assurances. From time to time and without additional consideration, Securityholder shall
execute and deliver, or cause to be executed and delivered, such additional transfers, assignments, endorsements, Consents and
other instruments, and shall take such further actions, as Purchaser may reasonably request for the purpose of carrying out and
furthering the intent of this Support Agreement and the Merger Agreement.

 

7.3 Notices.
Any notice and other communications hereunder shall be sent in writing, addressed as specified below, and shall be deemed given:
(a) if by hand or recognized courier service, by 4:00 PM on a Business Day, addressee’s day and time, on the date of delivery,
and otherwise on the first Business Day after such delivery; (b) if by email, on the date that transmission is confirmed electronically,
if by 4:00 PM on a Business Day, addressee’s day and time, and otherwise on the first Business Day after the date of such
confirmation; or (c) five days after mailing by certified or registered mail, return receipt requested. notices shall be addressed
to the respective parties as follows (excluding telephone numbers, which are for convenience only), or to such other address as
a party shall specify to the others in accordance with these notice provisions:

 

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if to Purchaser, to:

 

Panacea Acquisition Corp.

357 Tehama Street, Floor 3

San Francisco, CA 94103

Attention: Oleg Nodelman

Email:       oleg@ecor1cap.com

 

with a copy (which shall not constitute
notice) to:

 

Skadden, Arps, Slate, Meagher
& Flom LLP

525 University Avenue, Suite #1400

Palo Alto, CA 94301

Attention: Michael J. Mies

Email:      michael.mies@skadden.com

 

if to the Company, to:

 

Nuvation Bio Inc.

1500 Broadway, Suite 1401

New York, NY 10036

Attention: David Hung, M.D.

Email:       david.hung@nuvationbio.com

 

with copies (which shall not constitute
notice) to:

 

Cooley LLP

101 California Street, 5th Floor

San Francisco, CA 94111

Attention: Kenneth Guernsey

Email:     kguernsey@cooley.com

 

if to Securityholder, to the address
or email address of such person set forth beneath the name of such Person on the applicable signature page hereto.

 

7.4 Severability.
A determination by a court or other legal authority that any provision that is not of the essence of this Support Agreement is
legally invalid shall not affect the validity or enforceability of any other provision hereof. The parties shall cooperate in good
faith to substitute (or cause such court or other legal authority to substitute) for any provision so held to be invalid a valid
provision, as alike in substance to such invalid provision as is lawful.

 

7.5 Entire
Agreement. This Support Agreement, together with the Additional Agreements to which Securityholder
is a party sets forth the entire agreement of the parties with respect to the subject matter hereof and thereof and supersedes
all prior and contemporaneous understandings and agreements related to the subject matter hereof and thereto (whether written or
oral), all of which are merged herein. Except as otherwise expressly stated herein, there is no condition precedent to the effectiveness
of any provision hereof or thereof. No party has relied on any representation from, or warranty or agreement of, any Person in
entering into this Support Agreement, prior hereto or contemporaneous herewith, except those expressly stated herein or therein.

 

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7.6 Amendment.
This Support Agreement cannot be amended, except by a writing signed by each party, and cannot be terminated orally or by course
of conduct. 

 

7.7 Assignment;
Binding Effect. Neither this Support Agreement nor any of the rights, interests or obligations
hereunder may be assigned or delegated by Securityholder, and any attempted or purported assignment or delegation of any of such
interests or obligations shall be null and void. Subject to the preceding sentence, this Support Agreement shall be binding upon
each of the parties hereto, their respective heirs, estates, executors and personal representatives (if applicable) and their respective
successors and assigns, and shall inure to the benefit of each of the parties hereto and their respective successors and assigns.

 

7.8 Third-Party
Beneficiaries.  Neither this Support Agreement nor any provision hereof confers any benefit
or right upon or may be enforced by any Person not a signatory hereto.

 

7.9 Specific
Performance. The parties hereto acknowledge that the rights of each party contemplated
hereby are unique, recognize and affirm that in the event of a breach of this Support Agreement by any party, money damages would
be inadequate and the non-breaching parties would not have adequate remedy at law, and agree that irreparable damage would occur
in the event that any of the provisions of this Support Agreement were not performed by an applicable party in accordance with
their specific terms or were otherwise breached. Accordingly, each party shall be entitled to an injunction or restraining order
to prevent breaches of this Support Agreement and to seek to enforce specifically the terms and provisions hereof, without the
requirement to post any bond or other security or to prove that money damages would be inadequate, this being in addition to any
other right or remedy to which such party may be entitled under this Support Agreement, at law or in equity.

 

7.10 Governing
Law. This Support Agreement shall be construed in accordance with and governed by the
laws of the State of Delaware, without giving effect to the conflict of laws principles thereof.

 

7.11 Consent
to Jurisdiction; Waiver of Trial by Jury. Any Action based upon, arising
out of or related to this Support Agreement or the transactions contemplated hereby may be brought in federal and state courts
located in the State of Delaware, and each of the parties irrevocably submits to the exclusive jurisdiction of each such court
in any such Action, waives any objection it may now or hereafter have to personal jurisdiction, venue or to convenience of forum,
agrees that all claims in respect of the Action shall be heard and determined only in any such court, and agrees not to bring
any Action arising out of or relating to this Support Agreement or the transactions contemplated hereby in any other court. Nothing
herein contained shall be deemed to affect the right of any party to serve process in any manner permitted by Law or to commence
legal proceedings or otherwise proceed against any other party in any other jurisdiction, in each case, to enforce judgments obtained
in any Action brought pursuant to this Section 7.11. EACH OF THE PARTIES HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO
TRIAL BY JURY IN ANY ACTION BASED UPON, ARISING OUT OF OR RELATED TO THIS SUPPORT AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY.

 

7.12 Attorneys’
Fees. If any Action, suit or other Action relating to this Support Agreement or the enforcement
of any provision of this Support Agreement is brought against Securityholder, the prevailing party in such Action as determined
in a final, non-appealable decision by a court of competent jurisdiction, suit or other Action shall be entitled to receive the
costs incurred by such party in conducting the suit, Action or proceeding, including reasonable attorneys’ fees and expenses
and court costs (in addition to any other relief to which such prevailing party may be entitled).

 

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7.13 Counterparts;
Electronic Signatures. This Support Agreement may be executed in counterparts, each of
which shall constitute an original, but all of which shall constitute one agreement. This Support Agreement shall become effective
upon delivery to each party of an executed counterpart or the earlier delivery to each party of original, photocopied, or electronically
transmitted signature pages that together (but need not individually) bear the signatures of all other parties.

 

7.14 No
Ownership Interest. Nothing contained in this Agreement shall be deemed to vest in Purchaser
any direct or indirect ownership or incidence of ownership of or with respect to any Subject Securities.

 

7.15 Directors
and Officers. Nothing in this Agreement shall be construed to impose any obligation or
limitation on votes or actions taken by any director, officer, employee, agent, designee or other representative of any Securityholder
or by any Securityholder that is a natural person, in each case, in his or her capacity as a director or officer of the Company.
Each Securityholder is executing this Agreement solely in such capacity as a record or beneficial holder of Company Capital Stock.

 

7.16 Headings.
The headings used in this Support Agreement have been inserted for convenience of reference only and do not define or limit the
provisions hereof.

 

7.17 Extension;
Waiver. At any time prior to the Closing, Purchaser (on behalf of itself and Merger Sub),
on the one hand, and Securityholder, on the other hand, may, to the extent not prohibited by applicable Laws: (i) extend the time
for the performance of any of the obligations or other acts of the other parties hereto; (ii) waive any inaccuracies in the representations
and warranties made to the other parties hereto contained herein or in any document delivered pursuant hereto; and (iii) waive
compliance with any of the agreements or conditions for the benefit of such party contained herein. Any agreement on the part of
a party hereto to any such extension or waiver shall be valid only if set forth in an instrument in writing signed on behalf of
such party. No failure or delay on the part of either party to exercise any power, right, privilege or remedy under this Support
Agreement shall operate as a waiver of such power, right, privilege or remedy; and no single or partial exercise of any such power,
right, privilege or remedy shall preclude any other or further exercise thereof or of any other power, right, privilege or remedy.
Neither party shall be deemed to have waived any claim available to such party arising out of this Support Agreement, or any power,
right, privilege or remedy under this Support Agreement, unless the waiver of such claim, power, right, privilege or remedy is
expressly set forth in a written instrument duly executed and delivered on behalf of such waiving party; and any such waiver shall
not be applicable or have any effect except in the specific instance in which it is given.

 

7.18 Independence
of Obligations. The covenants and obligations of Securityholder set forth in this Support
Agreement shall be construed as independent of any other Contract between Securityholder, on the one hand, and the Company or Purchaser,
on the other hand. The existence of any claim or cause of action by Securityholder against the Company or Purchaser shall not constitute
a defense to the enforcement of any of such covenants or obligations against Securityholder. Nothing in this Support Agreement
shall limit any of the rights or remedies of Purchaser under the Merger Agreement, or any of the rights or remedies of Purchaser
or any of the obligations of Securityholder under any agreement between such Person and Purchaser or any certificate or instrument
executed by such Person in favor of Purchaser; and nothing in the Merger Agreement or in any other such agreement, certificate
or instrument, shall limit any of the rights or remedies of Purchaser or any of the obligations of Securityholder under this Support
Agreement.

 

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7.19 Construction
of Certain Terms and References; Captions. In this Support Agreement:

 

(a) The
words “herein,” “hereof,” “hereunder,” and words of similar import refer to this Support Agreement
as a whole and not to any particular provision of this Support Agreement.

 

(b) Any
use of the singular or plural, or the masculine, feminine, or neuter gender, includes the others, unless the context otherwise
requires; “including” means “including without limitation;” “or” means “and/or;”
“any” means “any one, more than one, or all,”

 

(c) Unless
otherwise specified, any reference to any agreement (including this Support Agreement), instrument, or other document includes
all schedules, exhibits, or other attachments referred to therein, and any reference to a statute or other Law includes any rule,
regulation, ordinance, or the like promulgated thereunder, in each case, as amended, restated, supplemented, or otherwise modified
from time to time.

 

(d) If
any action is required to be taken or notice is required to be given within a specified number of days following a specific date
or event, the day of such date or event is not counted in determining the last day for such action or notice. If any action is
required to be taken or notice is required to be given on or before a particular day which is not a Business Day, such action or
notice shall be considered timely if it is taken or given on or before the next Business Day.

 

(e) Captions
are not a part of this Support Agreement, but are included for convenience, only.

 

(f) “knowledge”
with respect to an entity shall mean with respect to any matter in question the actual knowledge of such entity’s executive
officers after reasonable inquiry.

 

[Remainder of page intentionally left
blank.]

 

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In
Witness Whereof, the parties have caused this Support Agreement to be executed as of the date first written above.

 

	 	Panacea Acquisition Corp.
	 	 
	 	By:	 
	 	 	Name:  	 
	 	 	Title:	 

 

Signature Page to Support Agreement

 

     

     

    

 

In
Witness Whereof, the parties have caused this Support Agreement to be executed as of the date first written above.

 

	 	Securityholder:
	 	 
	 	 
	 	Signature 
	 	 
	 	 
	 	Printed Name
	 	 
	 	Address:
	 	 
	 	 
	 	 
	 	 
	 	 
	 	 
	 	 
	 	Email:  	                       

 

	Class of Shares Held of Record	 
	Number of Shares Held of Record	 
	Class of Shares To Be Acquired	 
	Additional Number of Shares To Be Acquired	 
	Company Options Held of Record	 
	Number and Type of Other Rights Held of Record	 

 

 

Signature Page to Support AgreementExhibit 10.4

 

Execution Version

 

October 20, 2020

 

Panacea Acquisition Corp.

357 Tehama Street

Floor 3

San Francisco, CA 94103

 

Re: Lock-Up Agreement for EcoR1 Panacea
Holdings, LLC and PA Co-Investment LLC

 

Ladies and Gentlemen:

 

This letter (this “Letter
Agreement”) is being delivered to you in accordance with the Agreement and Plan of Merger (the “MA”)
entered into by and among Panacea Acquisition Corp., a Delaware corporation (the “Company”), Panacea
Merger Subsidiary Corp., a Delaware corporation (“Merger Sub”) and Nuvation Bio Inc., a Delaware corporation
(“Nuvation”), pursuant to which, among other things, Merger Sub will be merged with and into Nuvation
on the date hereof (the “Merger”), with Nuvation surviving the Merger as a wholly owned subsidiary of
the Company.

 

In order to induce
the Company to proceed with the Merger and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the undersigned (the “Securityholder”) hereby agrees with the Company as follows:

 

1. Subject
to the exceptions set forth herein, the Securityholder agrees not to, without the prior written consent of the board of directors
of the Company, (i) sell, offer to sell, contract or agree to sell, hypothecate, pledge, grant any option, right or warrant to
purchase or otherwise transfer, dispose of or agree to transfer or dispose of, directly or indirectly, or establish or increase
a put equivalent position or liquidate or decrease a call equivalent position within the meaning of Section 16 of the Securities
Exchange Act of 1934, as amended (the “Exchange Act”), and the rules and regulations of the Securities
and Exchange Commission promulgated thereunder, any currently outstanding Class B Common Stock, par value $0.0001 per share, of
the Company (the “Existing Class B Common Stock”) issued in connection with the public offering of the
Company (or shares of Class A Common Stock, par value $0.0001 per share, of the Company (the “Class A Common Stock”)
issuable upon conversion of the Existing Class B Common Stock) held by it immediately after the effective time of the Merger (the
“Lock-up Shares”), (ii) enter into any swap or other arrangement that transfers to another, in whole
or in part, any of the economic consequences of ownership of any of the Lock-up Shares, whether any such transaction is to be settled
by delivery of such securities, in cash or otherwise or (iii) publicly announce any intention to effect any transaction specified
in clause (i) or (ii) (the actions specified in clauses (i)-(iii), collectively, “Transfer”) until 365
days after the closing date of the Merger (the “Lock-Up Period”), subject to the early release provisions
set forth in Section 3 below.

 

2. The
restrictions set forth in paragraph 1 shall not apply to:

 

		(i)	in the case of an entity, (A) to another entity that is an affiliate (as defined in Rule 405 promulgated
under the Securities Act of 1933, as amended) of the undersigned, or to any investment fund or other entity controlling, controlled
by, managing or managed by or under common control with the undersigned or affiliates of the undersigned or who shares a common
investment advisor with the undersigned or (B) as part of a distribution to members, partners or shareholders of the undersigned;

 

     

     

    

 

		(ii)	in the case of an individual, Transfers by gift to members of the individual’s immediate
family (as defined below) or to a trust, the beneficiary of which is a member of one of the individual’s immediate family,
an affiliate of such person or to a charitable organization;

 

		(iii)	in the case of an individual, Transfers by virtue of laws of descent and distribution upon death
of the individual;

 

		(iv)	in the case of an individual, Transfers by operation of law or pursuant to a court order, such
as a qualified domestic relations order, divorce decree or separation agreement;

 

		(v)	in the case of an individual, Transfers to a partnership, limited liability company or other entity
of which the undersigned and/or the immediate family (as defined below) of the undersigned are the legal and beneficial owner of
all of the outstanding equity securities or similar interests;

 

		(vi)	in the case of an entity that is a trust, to a trustor or beneficiary of the trust or to the estate
of a beneficiary of such trust;

 

		(vii)	in the case of an entity, Transfers by virtue of the laws of the state of the entity’s organization
and the entity’s organizational documents upon dissolution of the entity;

 

		(viii)	Transfers of any shares of Class A Common Stock or Class B Common Stock, par value $0.001 per share
of the Company with such rights and characteristics as are described in the certificate of incorporation of the Company as in effect
immediately following the Merger (the “Class B Common Stock” and together with the Class A Common Stock,
the “Common Stock”) or other securities acquired as part of the PIPE (as defined in the MA) or issued
in exchange for, or on conversion or exercise of, any securities issued as part of the PIPE;

 

		(ix)	transactions relating to Common Stock or other securities convertible into or exercisable or exchangeable
for Common Stock acquired in open market transactions after the effective time of the Merger, provided that no such transaction
is required to be, or is, publicly announced (whether on Form 4, Form 5 or otherwise, other than a required filing on Schedule
13F, 13G or 13G/A) during the Lock-Up Period;

 

		(x)	the exercise of stock options or warrants to purchase shares of Common Stock or the vesting of
stock awards of Common Stock and any related transfer of shares of Common Stock to the Company in connection therewith (x) deemed
to occur upon the “cashless” or “net” exercise of such options or warrants or (y) for the purpose of paying
the exercise price of such options or warrants or for paying taxes due as a result of the exercise of such options or warrants,
the vesting of such options, warrants or stock awards, or as a result of the vesting of such shares of Common Stock, it being understood
that all shares of Common Stock received upon such exercise, vesting or transfer will remain subject to the restrictions of this
Letter Agreement during the Lock-Up Period;

 

		(xi)	Transfers to the Company pursuant to any contractual arrangement in effect at the effective time
of the Merger that provides for the repurchase by the Company or forfeiture of Common Stock or other securities convertible into
or exercisable or exchangeable for Common Stock in connection with the termination of the Securityholder’s service to the
Company;

 

    2

     

    

 

		(xii)	the entry, by the Securityholder, at any time after the effective time of the Merger, of any trading
plan providing for the sale of shares of Common Stock by the Securityholder, which trading plan meets the requirements of Rule
10b5-1(c) under the Exchange Act, provided, however, that such plan does not provide for, or permit, the sale of
any shares of Common Stock during the Lock-Up Period and no public announcement or filing is voluntarily made or required regarding
such plan during the Lock-Up Period;

 

		(xiii)	transactions in the event of completion of a liquidation, merger, stock exchange or other similar
transaction which results in all of the Company’s securityholders having the right to exchange their shares of Common Stock
for cash, securities or other property; and

 

		(xiv)	transactions to satisfy any U.S. federal, state, or local income tax obligations of the Securityholder
(or its direct or indirect owners) arising from a change in the U.S. Internal Revenue Code of 1986, as amended (the “Code”),
or the U.S. Treasury Regulations promulgated thereunder (the “Regulations”) after the date on which the
MA was executed by the parties, and such change prevents the Merger from qualifying as a “reorganization” pursuant
to Section 368 of the Code (and the Merger does not qualify for similar tax-free treatment pursuant to any successor or other provision
of the Code or Regulations taking into account such changes), in each case solely and to the extent necessary to cover any tax
liability as a direct result of the transaction.

 

provided, however, that (A) in the
case of clauses (i) through (vii), these permitted transferees must enter into a written agreement, in substantially the form of
this Letter Agreement (it being understood that any references to “immediate family” in the agreement executed by such
transferee shall expressly refer only to the immediate family of the Securityholder and not to the immediate family of the transferee),
agreeing to be bound by these Transfer restrictions. For purposes of this paragraph, “immediate family” shall mean
a spouse, domestic partner, child (including by adoption), father, mother, brother or sister of the undersigned, and lineal descendant
(including by adoption) of the undersigned or of any of the foregoing persons; and “affiliate” shall have the meaning
set forth in Rule 405 under the Securities Act of 1933, as amended.

 

3. In
the event that the Company releases or waives, in full or in part, any party from a lock-up agreement entered into in connection
with the closing of the Merger, then the same percentage of Lock-up Shares held by the undersigned as the percentage of Lock-up
Shares (or such equivalent term as defined in such lock-up agreement) held by such released party to such party’s aggregate
number of Lock-up Shares that are the subject of such waiver or release shall be immediately and fully released on the same terms
from the applicable prohibition(s) set forth herein. The foregoing provisions of this paragraph will not apply if the release or
waiver is granted to a holder of Common Stock in connection with a follow-on public offering of Common Stock pursuant to a registration
statement filed with the SEC, whether or not such offering or sale is wholly or partially a secondary offering of the Common Stock,
and the undersigned, only to the extent the undersigned has a contractual right to demand or require the registration of the undersigned’s
Common Stock or “piggyback” on a registration statement filed by the Company for the offer and sale of its Common Stock,
has been given an opportunity to participate on a basis consistent with such contractual rights in such follow-on offering. In
the event that the Company changes, amends, modifies or waives (other than to correct a typographical error) any particular provision
of any other lock-up agreement entered into in connection with the closing of the Merger, then the undersigned shall be offered
the option (but not the requirement) to make a corresponding change, amendment, modification or waiver to this Letter Agreement.

 

    3

     

    

 

4. The
Lock-Up Period shall terminate upon the earlier of (i) 365 days after the closing date of the Merger, (ii) the closing of a merger,
liquidation, stock exchange, reorganization or other similar transaction after the closing date of the Merger that results in all
of the public stockholders of the Company having the right to exchange their shares of Common Stock for cash securities or other
property, or (iii) the day after the date on which the closing price of the Class A Common Stock equals or exceeds $12.00 per share
(as adjusted for share splits, share capitalizations, reorganizations, recapitalizations and the like) for any 20 trading days
within any 30-trading day period commencing at least 150 days after the closing date of the Merger.

 

5. In
furtherance of the foregoing, the Company, and any duly appointed transfer agent for the registration or transfer of the securities
described therein, are hereby authorized to decline to make any transfer of securities if such transfer would constitute a violation
or breach of this Letter Agreement.

 

6. This
Letter Agreement replaces Section 7(a) of that certain Letter Agreement, dated June 30, 2020, among the Company, the Sponsor, Cowen
Investments and the Company’s officers and directors, which Section 7(a) shall be terminated and of no further effect with
respect to Securityholder upon the Closing of the Merger, and constitutes the entire agreement and understanding of the parties
hereto in respect of the subject matter hereof and supersedes all prior understandings, agreements or representations by or among
the parties hereto, written or oral, to the extent they relate in any way to the subject matter hereof or the transactions contemplated
hereby. This Letter Agreement may not be changed, amended, modified or waived (other than to correct a typographical error) as
to any particular provision, except by a written instrument executed by the undersigned (i) Securityholder and (ii) the Company.

 

7. No
party hereto may assign either this Letter Agreement or any of its rights, interests or obligations hereunder without the prior
written consent of the other party. Any purported assignment in violation of this paragraph shall be void and ineffectual and shall
not operate to transfer or assign any interest or title to the purported assignee. This Letter Agreement shall be binding on the
Securityholder and each of its respective successors, heirs and assigns and permitted transferees.

 

8. This
Letter Agreement shall be governed by and construed and enforced in accordance with the laws of the State of Delaware, without
giving effect to conflicts of law principles that would result in the application of the substantive laws of another jurisdiction.
The parties hereto (i) all agree that any action, proceeding, claim or dispute arising out of, or relating in any way to, this
Letter Agreement shall be brought and enforced in the Delaware Chancery Court, and irrevocably submit to such jurisdiction and
venue, which jurisdiction and venue shall be exclusive and (ii) waive any objection to such exclusive jurisdiction and venue or
that such courts represent an inconvenient forum.

 

9. This
Letter Agreement shall terminate on the earlier of (i) the expiration of the Lock-up Period and (ii) the liquidation of the Company.

 

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    4

     

    

 

	 	Very truly yours,
	 	 
	 	If stockholder is an individual:
	 	 
	 	Signature:	 
	 	 	 
	 	Print Name:	 
	 	 	 
	 	If stockholder is an entity:
	 	 	 
	 	Name of Stockholder:   	 
	 	 	 
	 	Signature:	 
	 	 	 
	 	Name:	 
	 	 	 
	 	Title: 	 

 

	Agreed and Acknowledged:	 
	 	 	 
	Panacea Acquisition Corp	 
	 	 	 
	By:	/s/	 
	 	 	 	 
	 	Name:  	                     	 
	 	 	 	 
	 	Title:	 	 

 

 

[Signature Page to Lock-Up Agreement]

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