Document:

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                                                                   EXHIBIT 10.37

                                 PROMISSORY NOTE
                                  JUNE 27, 2003

FOR VALUE RECEIVED, LA JOLLA PHARMACEUTICAL COMPANY a corporation located at the
address stated below ("MAKER") promises, jointly and severally if more than one,
to pay to the order of GENERAL ELECTRIC CAPITAL CORPORATION or any subsequent
holder hereof (each, a "PAYEE") at its office located at 401 MERRITT 7 SUITE 23,
NORWALK, CT 06851-1177 or at such other place as Payee or the holder hereof may
designate, the principal sum of THREE HUNDRED FORTY-FIVE THOUSAND TWO HUNDRED
THIRTY-NINE AND 47/100 DOLLARS ($345, 239.47), with interest on the unpaid
principal balance, from the date hereof through and including the dates of
payment, at a fixed interest rate of Nine and Seventy Hundreths percent (9.70%)
per annum, to be paid in lawful money of the United States, in Fourty Two (42)
consecutive monthly installments of principal and interest as follows:

<TABLE>
<CAPTION>
   Periodic
  Installment         Amount
  -----------         ------
<S>                 <C>
Thirty-Six (36)     $10,140.33
Five (5)            $ 6,146.05
</TABLE>

each ("Periodic Installment") and a final installment which shall be in the
amount of the total outstanding principal and interest. The first Periodic
Installment shall be due and payable on July 1, 2003 and the following Periodic
Installments and the final installment shall be due and payable on the same day
of each succeeding month (each, a "Payment Date"). Such installments have been
calculated on the basis of a 360 day year of twelve 30-day months. Each payment
may, at the option of the Payee, be calculated and applied on an assumption that
such payment would be made on its due date.

The acceptance by Payee of any payment which is less than payment in full of all
amounts due and owing at such time shall not constitute a waiver of Payee's
right to receive payment in full at such time or at any prior or subsequent
time.

The Maker hereby expressly authorizes the Payee to insert the date value is
actually given in the blank space on the face hereof and on all related
documents pertaining hereto.

This Note may be secured by a security agreement, chattel mortgage, pledge
agreement or like instrument (each of which is hereinafter called a "SECURITY
AGREEMENT").

Time is of the essence hereof. If any installment or any other sum due under
this Note or any Security Agreement is not received within ten (10) days after
its due date, the Maker agrees to pay, in addition to the amount of each such
installment or other sum, a late payment charge of five percent (5%) of the
amount of said installment or other sum, but not exceeding any lawful maximum.
If (i) Maker fails to make payment of any amount due hereunder within ten (10)
days after the same becomes due and payable; or (ii) Maker is in default under,
or fails to perform under any term or condition contained in any Security
Agreement, then the entire principal sum remaining unpaid, together with all
accrued interest thereon and any other sum payable under this Note or any
Security Agreement, at the election of Payee, shall immediately become due and
payable, with interest thereon at the lesser of eighteen percent (18%) per annum
or the highest rate not prohibited by applicable law from the date of such
accelerated maturity until paid (both before and after any judgment).

Notwithstanding anything to tire contrary contained herein or in the Security
Agreement, Maker may not prepay in full or in part any indebtedness hereunder
without the express written consent of Payee in its sole discretion.

It is the intention of the parties hereto to comply with the applicable usury
laws; accordingly, it is agreed that, notwithstanding any provision to the
contrary in this Note or any Security Agreement, in no event shall this Note or
any Security Agreement require the payment or permit the collection of interest
in excess of the maximum amount permitted by applicable law. If any such excess
interest is contracted for, charged or received under this Note or any Security
Agreement, or if all of the principal balance shall be prepaid, so that under
any of such circumstances the amount of interest contracted for, charged or
received under this Note or any Security Agreement on the principal balance
shall exceed the maximum amount of interest permitted by applicable law, then in
such event (a) the provisions of this paragraph shall govern and control, (b)
neither Maker nor any other person or entity now or hereafter

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liable for the payment hereof shall be obligated to pay the amount of such
interest to the extent that it is in excess of the maximum amount of interest
permitted by applicable law, (c) any such excess which may have been collected
shall be either applied as a credit against the then unpaid principal balance or
refunded to Maker, at the option of the Payee, and (d) the effective rate of
interest shall be automatically reduced to the maximum lawful contract rate
allowed under applicable law as now or hereafter construed by the courts having
jurisdiction thereof. It is further agreed that without limitation of the
foregoing, all calculations of the rate of interest contracted for charged or
received under this Note or any Security Agreement which are made for the
purpose of determining whether such rate exceeds the maximum lawful contract
rate, shall be made, to the extent permitted by applicable law, by amortizing,
prorating, allocating and spreading in equal parts during the period of the full
stated term of the indebtedness evidenced hereby, all interest at any time
contracted for, charged or received from Maker or otherwise by Payee in
connection with such indebtedness; provided, however, that if any applicable
state law is amended or the law of the United States of America preempts any
applicable state law, so that it becomes lawful for the Payee to receive a
greater interest per annum rate than is presently allowed, the Maker agrees
that, on the effective date of such amendment or preemption, as the case may be,
the lawful maximum hereunder shall be increased to the maximum interest per
annum rate allowed by the amended state law or the law of the United States of
America.

The Maker and all sureties, endorsers, guarantors or any others (each such
person, other than the Maker, an "OBLIGOR") who may at any time become liable
for the payment hereof jointly and severally consent hereby to any and all
extensions of time, renewals, waivers or modifications of, and all substitutions
or releases of, security or of any party primarily or secondarily liable on this
Note or any Security Agreement or any term and provision of either, which may be
made granted or consented to by Payee, and agree that suit may be brought and
maintained against any one or more of them, at the election of Payee without
joinder of any other as a party thereto, and that Payee shall not be required
first to foreclose, proceed against, or exhaust any security hereof in order to
enforce payment of this Note. The Maker and each Obligor hereby waives
presentment, demand for payment, notice of nonpayment, protest, notice of
protest, notice of dishonor, and all other notices in connection herewith, as
well as filing of suit (if permitted by law) and diligence in collecting this
Note or enforcing any of the security hereof, and agrees to pay (if permitted by
law) all expenses incurred in collection, including Payee's actual attorneys'
fees. Maker and each Obligor agrees that fees not in excess of twenty percent
(20%) of the amount then due shall be deemed reasonable.

THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM
OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY OR INDIRECTLY, THIS
NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE
RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS,
AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN MAKER AND PAYEE. THE
SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES
THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS,
TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY
CLAIMS.) THIS WAIVER IS IRREVOCABLE MEANING THAT IT MAY NOT BE MODIFIED EITHER
ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS,
RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR
TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED
TRANSACTION. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN
CONSENT TO A TRIAL BY THE COURT.

This Note and any Security Agreement constitute the entire agreement of the
Maker and Payee with respect to the subject matter hereof and supercedes all
prior understandings, agreements and representations, express or implied.

No variation or modification of this Note, or any waiver of any of its
provisions or conditions, shall be valid unless in writing and signed by an
authorized representative of Maker and Payee. Any such waiver, consent,
modification or change shall be effective only in the specific instance and for
the specific purpose given.

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Any provision in this Note or any Security Agreement which is in conflict with
any statute, law or applicable rule shall be deemed omitted, modified or altered
to conform thereto.

                                  LA JOLLA PHARMACEUTICAL COMPANY

/s/ Lisa Peraza                   By: /s/ Gail A. Sloan
---------------                       -----------------
Lisa Peraza (Witness)                 Gail A. Sloan
6455 Nancy Ridge Drive                Senior Director of Finance and Controller
San Diego, CA 92121
                                      Federal Tax ID #: 330361285
                                      Address: 6455 Nancy Ridge Drive
                                      San Diego, CA 92121<PAGE>

                                                                   EXHIBIT 10.38

                     AMENDMENT NO. 3 TO EMPLOYMENT AGREEMENT

         This Amendment No. 3 to Employment Agreement (this "Amendment No. 3")
is made effective as of July 23, 2003, by and between La Jolla Pharmaceutical
Company, a Delaware corporation (the "Company"), and Steven B. Engle
("Executive").

         WHEREAS, Executive and the Company are parties to that certain
Employment Agreement dated as of December 30, 1993 (the "Original Employment
Agreement"), as amended by Amendment No. 1 to Employment Agreement, dated as of
June 26, 1997 ("Amendment No. 1"), and Amendment No. 2 to Employment Agreement,
dated as of September 16, 1999 ("Amendment No. 2"), and pursuant to which
Executive is employed by the Company (the Original Employment Agreement,
Amendment No. 1, and Amendment No. 2, being collectively referred to herein as
the "Agreement"); and

         WHEREAS, Executive and the Company desire to amend the Agreement as set
forth herein in consideration of Executive's ongoing employment.

         NOW, THEREFORE, the Company and Executive hereby agree as follows:

         1.       Section 4(a)(i) of Amendment No. 2 shall be deleted in its
entirety and replaced with the following:

                  "(i) the Company (or its successor, as the case may be) shall
                  pay to Executive a severance payment (the "Severance Payment")
                  equal to the then-current Base Salary for a period of
                  twenty-four (24) full calendar months from the date of
                  termination of Executive's employment (the "Termination
                  Date"); and"

         2.       Section 4(a)(ii) of Amendment No. 2 shall be deleted in its
entirety and replaced with the following:

                  "(ii) the Company (or its successor, as the case may be) shall
                  continue, at its sole expense, all medical, dental and life
                  insurance coverage for Executive and his family on similar
                  terms until the earlier of (A) twenty-four (24) full calendar
                  months from the Termination Date, or (B) such time as
                  Executive receives similar paid coverage from another
                  employer; and"

         3.       Nothing in this Amendment No. 3 shall be construed to limit
benefits to which Executive is entitled under the Agreement. Except as expressly
amended hereby, the Agreement remains in full force and effect as written.

         4.       This Amendment No. 3 may be executed in any number of
counterparts, each of which when so executed shall be deemed to be an original
and all of which when taken together shall constitute one and the same
agreement.

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         IN WITNESS WHEREOF, Executive and the Company have entered into this
Amendment No. 3 as of the date written above.

LA JOLLA PHARMACEUTICAL COMPANY                                      EXECUTIVE

By: /s/ Gail A. Sloan                                        /s/ Steven B. Engle
    -----------------                                        -------------------
    Gail A. Sloan                                            Steven B. Engle
    Senior Director of Finance, Controller, and Secretary

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