Document:

Exhibit

Exhibit 4.3

VASTox plc

2005 EMI Scheme Rules

Adopted by the Board of Directors 
on 1 December 2005

RULES OF THE VASTOX PLC 2005 
ENTERPRISE  MANAGEMENT  INCENTIVE SCHEME

CONTENTS

Rule

		
	1.
	Definitions  and interpretation

		
	2.
	Grant of Options

		
	3.
	Conditions  of exercise

		
	4.
	Individual limits

		
	5.
	Scheme limits

		
	6.
	Rights of exercise and lapse of Options

		
	7.
	Exercise of Options

		
	8.
	Takeovers  and Liquidations

		
	9.
	Exchange of Options on a  takeover

		
	10.
	Variation of share  capital

		
	11.
	Administration

		
	12.
	Amendments

		
	13.
	General

RULES OF THE VASTOX PLC 2005  ENTERPRISE  MANAGEMENT  INCENTIVE  SCHEME (“EMI”)

		
	1.
	DEFINITIONS  AND  INTERPRETATION

In this Scheme, the following words and expressions shall,  where  the context  so permits,  have the following meanings:

		
	“Agreement”
	means the agreement  in writing  granting an Option   pursuant to this Scheme in such form as the Directors shall from time   to time determine but in all cases issued under a seal or executed as a deed by the Grantor and accepted in writing by the Eligible Employee;

“Auditors”        means the auditors for the time being of the Company;
“Committed Time”    has the meaning given in paragraph 26(2) of Schedule 5;
“the Company”        means   Vastox plc registered in England under number 05197494;
		
	“Company Limit”
	means £3 million or such other amount as may from time to time be specified in paragraph 7 of Schedule  5;

“Connected Person”    has the meaning given by Section 839 of ICTA;
“Control” and cognate    has the meaning given by Section 840 of ICTA;
expressions"
		
	“CSOP Option”
	means a share option granted under a scheme approved by  the Inland Revenue under   Schedule 4 to ITEPA by virtue of employment with a Group  Company;

		
	“Date of Grant”
	means the date on which an Option is granted as evidenced by the date at the head of the Agreement;

		
	“Directors”
	means  the  Board  of  Directors for the time being of the Company or a duly authorised committee  thereof;

		
	“Disqualifying Event”
	means an event specified in Sections 534 to 536 inclusive of ITEPA   which  causes   an  EMI  Option to cease to be a qualifying option for the purposes of the EMI  Code;

“Eligible Employee”    means an individual:
		
	(a)
	who is a bona fide employee or director of the  Company or a Qualifying Subsidiary;  and

		
	(b)
	in respect of an EMI Option whose Committed Time is at least 25 hours per week, or, if less, 75% of his Working Time; and

(c)in respect of an EMI Option who is not precluded from such participation by paragraph 28 of Schedule 5 (no material interest);
“EMI Code”        has the meaning given in Section 527(3) of  ITEPA;
		
	“EMI Option”
	means  an  Option which is a qualifying option within the meaning given in Section 527 of ITEPA;

		
	“Employer Company”
	means the company by reason of whose employment an EMI Option has been granted to an Eligible  Employee;

		
	“Exercise Price”
	means  the  price  at  which  each  Share  subject  to  an Option may be acquired on the exercise of the Option, being (subject to Rule 10) not less than:-

		
	(a)
	the price determined by the Directors in their absolute discretion; or

(b)if greater, and Shares are to be subscribed, the nominal value of a Share;
“Exit Event”        means a change of Control of the Company;
		
	“Further Limit”
	means £100,000  or such  other amount  as may from  time  to time be specified in paragraph 6 of Schedule  5;

		
	“Good Leaver”
	means   an   Optionholder   who   ceases   to   be   an   Eligible Employee by reason of:

		
	(a)
	ill-health,    injury,    disability    (evidenced    to    the satisfaction of the Directors); or

		
	(b)
	Redundancy, Retirement; pregnancy (the effective   date

of such cessation  being the date which  the provisions  of the Employment Rights Act 1996 cease to apply in respect of the office or employment);  or
		
	(c)
	a Transfer of Business

or who ceases to be an Eligible Employee and who is determined to be a Good Leaver by the Directors in their absolute discretion;
		
	“Grantor”
	means the Company,  the Directors, the Trustee or such  other person who grants an EMI Option under this  Scheme;

		
	“Gross Assets Limit”
	means £30 million or such other amount as may from time   to time be specified in paragraph 12 of Schedule  5.

“Group Company”    means:
		
	(a)
	the Company; or

		
	(b)
	any Subsidiary of the Company;

“ICTA”            means the Income and Corporation Taxes Act  1988;
		
	“Individual Limit”
	means £100,000  or such  other amount  as may from time  to time be specified in paragraph 5 of Schedule  5;

“ITEPA”        means the Income Tax (Earnings and Pensions) Act   2003;
“the London Stock      means the London Stock Exchange plc or any of its successors;
Exchange"
		
	“Market Value”
	means the market value of a share as defined in paragraph 55 of Schedule  5 and determined in accordance with paragraph  56 of Schedule 5;

“Option”        means a right to acquire Shares pursuant to this  Scheme;
		
	“Optionholder”
	means a person who  has been  granted  an Option which  has neither lapsed nor been surrendered or exercised  and where  the context so requires, the legal personal representatives of such person;

“Qualifying Exchange    means arrangements which meet the conditions of  paragraph 40 of Schedule 5;
of shares"
“Qualifying Subsidiary”has the meaning given in paragraph 11 of Schedule  5;
“Redundancy”        has the meaning  given  to it by the Employment Rights Act 1996;
“Relevant Market”    has  the  meaning   given   in  article   37(4)   of  the   Financial
Services and Markets Act 2000 (Financial Promotion) Order 2001 as amended and reissued from time to time;
		
	“Retirement”
	means retirement  of the Optionholder  at  or after  the date  on which the Optionholder is normally expected to retire in accordance with the Optionholder’s contract of   employment;

“Restricted Period”    means the period of three years after the Date of Grant of   the
last EMI Option granted by reason of the Eligible Employee’s employment with a Group Company or such other period as may from time to time be specified in paragraph 6 of  Schedule 5;
		
	“Rules”
	means the Rules of this Scheme as amended from time to time;

“Schedule 5”        means Schedule 5 to ITEPA as amended from time to  time;
		
	“this Scheme”
	means the Vastox plc 2005 Enterprise Management  Incentive Scheme, as amended from time to time;

“Share”    means an ordinary share in the capital of the  Company which meets the requirements of paragraph 35 of Schedule  5;
		
	“Subsidiary”
	means   any   company   which   is   under   the  control   of the Company, determined in accordance with 416(2) to (6) of ICTA;

“Transfer of Business”    means:
		
	(a)
	the company for which the Optionholder works ceasing to be a Group Company; or

(b)the transfer of an undertaking or part-undertaking in which the Optionholder is employed to a person other than a Group Company;
		
	“Trustee”
	means  the  trustee  or  trustees  for  the  time  being  of  any employee benefit trust established by the  Company;

		
	“Unapproved Option”
	means  an  Option which  is  granted  pursuant  to this Scheme that is not a qualifying option for the purposes of the EMI Code;

		
	“Vest”
	means   the   crystallisation   of   an   Optionholder’s   right   to exercise the Option;

		
	“Vesting Date”
	means the date on which the Option Vests pursuant   to Rules 6.1, 6.5, 8.1 and 8.4 to 8.7; and

“Working Time”    has the meaning given in paragraph 27 of Schedule  5.

References to any statutory provision are to that provision as amended or re-enacted from time to time, and, unless the context otherwise requires, words in  the  singular  shall  include the plural and vice versa, and words importing the masculine gender shall include the feminine and vice versa.

		
	2.
	GRANT OF OPTIONS

		
	2.1
	Subject to Rules 2.8 to 2.14, the Grantor may grant an Option to an Eligible Employee   at any time and the Date of Grant of an Option shall be the date of the Agreement relating to that Option.

		
	2.2
	Notwithstanding Rule 4.1, where the Grantor grants an Option to an Eligible Employee which causes the aggregate Market Value  of:

		
	(a)
	all Shares or shares in respect of which unexercised EMI Options are then held by him and granted by reason of his employment with any one or more Group Companies; and

		
	(b)
	all Shares or shares in respect of which unexercised CSOP Options  are  held by  him,

to exceed the Individual Limit, the excess shall be an Unapproved  Option.
		
	2.3
	Notwithstanding Rule 2.13, where the Grantor grants an Option which results in the Market Value of Shares or shares in the Company in respect of which unexercised EMI Options subsist exceeding the Company Limit then the excess as  prescribed  by paragraph 7 of Schedule 5 shall be an Unapproved  Option.

		
	2.4
	Notwithstanding Rule 4.2, if an Eligible Employee has been granted EMI Options by reason of his 

employment with any one Group Company in respect of Shares or shares whose Market Value is equal to or greater than the Further Limit (irrespective  of  whether they have been exercised or released) any grant of an Option to him within the Restricted Period shall be an Unapproved  Option.
		
	2.5
	For the purposes of Rules 2.2 to 2.4 and 2.13, the Market Value of the Shares or shares shall be their Market Value at the date or dates on which the relevant Options or other options were granted or such earlier time or times as may be agreed with the Inland Revenue.

		
	2.6
	An Option shall be granted to an Eligible Employee by deed executed by the Grantor.   As soon as reasonably practicable after such grant, the Eligible Employee shall agree to such option grant by signing a form of acceptance. An Eligible Employee shall not be required to pay any consideration for the grant of an Option.   The Agreement shall be   in the form determined by the Directors from time to time. Either the Rules, the Agreement or both (including any relevant schedules or appendices) shall include (in relation to EMI Options) all details required pursuant to paragraph 37 of Schedule 5 including:

		
	(a)
	the Date of Grant of the EMI Option;

		
	(b)
	that the EMI Option is granted under the provisions of Schedule  5;

		
	(c)
	the number, or maximum number, of Shares that may be granted pursuant to the EMI Option;

		
	(d)
	the Exercise Price or the method by which that price is to be  determined;

		
	(e)
	when and how the EMI Option may be exercised;

		
	(f)
	any condition or conditions applicable pursuant to Rule 3.1;   and

		
	(g)
	any restrictions that cause the Shares to be Restricted Securities as defined  in Section 423 of ITEPA.

		
	2.7
	Subject to the right of a deceased Optionholder's personal representatives to exercise an Option in accordance with Rule 6.3 (death), every Option shall be personal  to  the Eligible Employee to whom it is granted and neither the Option nor the Optionholder’s rights under it shall be capable of being transferred, assigned or   charged.

		
	2.8
	The Grantor shall only grant an EMI Option if the EMI Option is granted for  commercial  reasons  in order to recruit or retain the Eligible Employee  and not as part  of a scheme or arrangement the main purpose, or one of the main purposes of which is the avoidance of tax.

		
	2.9
	The Grantor shall only grant an EMI Option if the Company is  neither:

		
	(a)
	a 51% subsidiary of another company;  nor

		
	(b)
	under the Control of:

		
	(i)
	another company; or

		
	(ii)
	another company and any other person Connected to that   company,

and there are no arrangements in existence (except for arrangements with a view to a Qualifying 

Exchange of Shares) by virtue of which the Company could become within (a) or (b).
		
	2.10
	The Grantor shall only grant an EMI Option if the Company or a Group Company as  the case may be meets the trading activities requirement of paragraph 13 or 14 of Schedule 5 at the Date of Grant.

		
	2.11
	The Grantor shall only grant an EMI Option if the gross assets of the Company are less than the Gross Assets Limit at the Date of Grant. If the Company is a member of a  group, the gross assets of the Company is the aggregate  value of the gross  assets of  each of the members of the group, disregarding any assets that consists in rights against  or shares in or securities of another member of the group. For the purposes of this sub- Rule “gross assets” is determined in accordance with Inland Revenue Statement of Practice 2/00 or its  successors.

		
	2.12
	The Grantor shall only grant an EMI Option if at the Date of Grant the Company has   no Subsidiaries which are not Qualifying   Subsidiaries.

		
	2.13
	The Grantor in the case of an EMI Option shall not grant an EMI Option if the total Market Value of Shares in the Company in respect of which unexercised EMI Options subsist exceeds the Company Limit.

		
	2.14
	An Option shall not be granted unless the Directors are satisfied  at the relevant  time  that all conditions relating to such grant pursuant to these Rules have been  met.

		
	2.15
	An EMI Option or part thereof as the case may be that fails in any manner to meet the provisions of the EMI Code shall be an Unapproved  Option.

		
	3.
	CONDITIONS OF EXERCISE

		
	3.1
	Subject to Rule 3.2, the Vesting Date or Dates and the extent to which the Option Vests on the given Vesting Date or Dates will be set out in the Agreement or otherwise determined pursuant to the Rules. Notwithstanding the generality of the foregoing (and subject to Rule 3.2), the Option may Vest on a specific date or dates, the occurrence of    a specific event or events or be conditional upon the achievement of a  given  performance  condition  or conditions.

		
	3.2
	An EMI Option must be capable of being exercised within the period of ten (10) years beginning with the Date of Grant. Where the exercise of the EMI Option is dependent upon the fulfilment of conditions, the EMI Option is to be taken to be capable of being exercised within the period of ten (10) years if such conditions may be fulfilled within  ten (10) years from the Date of Grant.

		
	3.3
	To the extent that the Option does not meet the requirements of Rule 3.2, the Option  shall be an Unapproved Option.

		
	3.4
	Where the Vesting of the Option is subject to a performance condition pursuant to Rule 3.1, the performance condition may be measured over a continuous period as set out in the Agreement commencing no earlier than the financial year during which the Option    is granted.

		
	3.5
	As soon as is reasonably practicable following the end of the period over which any performance conditions pursuant to Rule 3.1  are  measured,  the  Directors  will determine the extent to which the 

performance condition has been  achieved.
		
	3.6
	If, after the Grantor has imposed any performance condition to be satisfied pursuant to this Rule 3, events occur which cause the Grantor to consider that an amended performance condition would be a fairer measure of the  relevant  performance,  they may, in their discretion (provided such discretion is exercised fairly and reasonably) amend, relax or waive such targets or conditions provided that any targets or conditions which are amended will be no more and no less difficult to satisfy than when they were originally imposed or last amended or  relaxed.

		
	3.7
	The Directors shall notify all relevant Optionholders in writing of any amendment, relaxation or waiver of existing targets or conditions made pursuant to Rule  3.6.

		
	4.
	INDIVIDUAL  LIMITS

		
	4.1
	Any EMI Option granted to an Eligible Employee by the Grantor shall be limited and take effect so that, immediately following such grant, the aggregate Market Value   of:

		
	(a)
	all Shares or shares in respect of which unexercised EMI Options are then held by him and granted by reason of his employment with any one or more Group Companies; and

		
	(b)
	all Shares or shares in respect of which unexercised CSOP Options  are  held by  him,

shall not exceed the Individual  Limit.
		
	4.2
	If an Eligible Employee has been granted EMI Options  by reason  of his employment with any one Group Company in respect of Shares or shares whose Market Value is  equal to or greater than the Further Limit (irrespective of whether they have been exercised or released) no EMI Option shall be granted to him within the Restricted Period.

		
	4.3
	For the purposes of Rules 4.1 and 4.2, the Market Value of the Shares or shares shall be their Market Value at the date or dates on which the relevant EMI Options or other options were granted or such earlier time or times as may be agreed with the Inland Revenue.

		
	5.
	SCHEME LIMITS

		
	5.1
	The maximum number of Shares which may on any day be placed under option for subscription under this Scheme, when added to the number of Shares allocated for subscription in the preceding ten years under this or any other employees' share scheme adopted by the Company, shall not exceed fifteen per cent (15%) of the Company's  issued ordinary share capital immediately prior to that  day.

		
	5.2
	For the purpose of calculating the limit in Rule 5.1, any Shares comprised in any option for subscription or other right to subscribe which has lapsed shall be   disregarded.

		
	6.
	RIGHTS OF EXERCISE AND LAPSE OF OPTIONS

		
	6.1
	Subject to Rule 6.5 (Disqualifying Event), the Option shall Vest on the earliest of the date or dates set out in Agreement and the dates set out pursuant to Rules 8.1, and 8.4    to 8.7. The Optionholder shall be entitled to exercise his Option in accordance  with  Rule 7 from the Vesting Date.

		
	6.2
	Save as provided in Rules 6.3 (death) and 6.4 (Good Leavers) the Option may only be exercised by an Optionholder while he is an Eligible  Employee.

		
	6.3
	Subject to Rule 6.1, the Option may be exercised (to the extent that it has Vested) by  the  personal  representatives  of  a  deceased  Optionholder  during  the  period  of twelve (12) months following the date of  death.

		
	6.4
	Subject to Rule 6.1, where the Optionholder is a Good Leaver, the Optionholder may exercise his Option (to the extent that it has Vested) during the period of twelve (12)  months following the date of cessation of employment.

		
	6.5
	To the extent that the Grantor, where applicable acting upon a recommendation  from  the Directors, decides in its absolute discretion and notwithstanding  Rule  6.1,  an  Option may be exercised during the period of forty (40) days following a Disqualifying Event other than one which falls into Section 535 of ITEPA (Disqualifying Events relating to employees).

		
	6.6
	An Option shall lapse on the occurrence of the earliest of the  following:

		
	(a)
	ten (10) years from the Date of  Grant;

		
	(b)
	in the event that the Agreement in respect of the Option is not executed by the Optionholder within ninety (90) days  of the Date of Grant then 11.59pm  (GMT)  on the ninetieth (90th) day after the Date of  Grant;

		
	(c)
	the expiry of the period (if any) allowed for the satisfaction of any performance condition   pursuant   to  Rule  3.1  and  set   out  in  the  Agreement without such condition having been satisfied or the date on which it becomes apparent to the Grantor in their absolute  discretion  that any such condition  has become  incapable of being satisfied;

		
	(d)
	twelve (12) months from the date of the death of the  Optionholder;

		
	(e)
	subject to Rules 6.3 (death) and 6.4 (Good Leavers), 5:00pm on the day on which the Optionholder ceases to be an Eligible  Employee;

		
	(f)
	for a Good Leaver, twelve (12) months from the date on which the Optionholder ceases to be an Eligible Employee;

		
	(g)
	unless and to the extent the Grantor, where applicable upon recommendation from the Directors, decides otherwise and where the Grantor has permitted an exercise pursuant to Rule 6.5 (disqualifying events), the expiry of the period specified  in Rule 6.5;

		
	(h)
	if the grantor exercises its discretion pursuant to Rule 8.3,  the  date of an  Exit Event;

		
	(i)
	subject to Rule 9 (exchange of options on a takeover), the expiry of the period specified in Rule 8.4 (change of  Control);

		
	(j)
	subject to Rule 9 (exchange of options on a takeover), the expiry of the period specified in Rule 8.5 (compromise or  arrangement);

		
	(k)
	subject to Rule 9 (exchange of options on a takeover), the expiry of the period specified in Rule 8.6 (mandatory  offer);

		
	(l)
	the date on which a resolution is passed, or an order is made by the Court, for the compulsory winding up of the  Company;

		
	(m)
	the date on which the Optionholder becomes bankrupt or does or omits to do anything as a result of which he is deprived of the legal or beneficial ownership of the Option.

		
	7.
	EXERCISE OF OPTIONS

		
	7.1
	An Option shall be exercisable in whole or in part by notice in writing (in the form prescribed by the Company from time to time) given by the Optionholder (or  his personal representatives as the case may be) to the Company. The notice of exercise of the Option shall be accompanied by a remittance in cleared funds (or any other manner the Directors in their absolute discretion shall decide) for the aggregate of the Exercise Price payable. The Secretary of the Company shall receive  such  notice  or Exercise Price as the case may be on behalf of the Company, Grantor or as agent for the Trustee as applicable.

		
	7.2
	Subject to Rules 7.4, 7.5 and 7.6, the effective date of the exercise shall be the date that the Secretary of the Company receives both the notice of the exercise and  the  remittance pursuant to Rule 7.1.

		
	7.3
	Subject to Rules 7.4, 7.5 and 7.6, within 14 days of the Option exercise (or, if later, as soon as is reasonably practicable) the Directors shall allot or transfer the Shares in  respect of which the Option has been validly exercised and shall issue a definitive certificate in respect of the Shares allotted or transferred, unless the Directors consider that such allotment or transfer would not be lawful in the relevant   jurisdiction.

		
	7.4
	If any Group Company or a company that was previously a Group Company as the case may be is liable to account for Employers’ Secondary National Insurance Contributions (“Employers’ NIC”) by virtue of the exercise, release or cancellation of an Option the Directors may determine that the exercise of the Option is conditional upon the Optionholder either:

		
	(a)
	agreeing to meet the company’s liability to pay Employers’ NIC;  or

		
	(b)
	entering into an election to transfer the liability for Employers’ NIC in a form  approved by the Inland Revenue and enter into such arrangements as may be approved by the Inland Revenue in order to ensure that the  Employers’  NIC  liability can be met.

		
	7.5
	The Directors may determine that the exercise of the Option is conditional upon the Optionholder entering into an election under Section 431(1) of ITEPA that the Shares  are to be treated for the relevant tax 

purposes as if they were not restricted  securities.
		
	7.6
	If any Group Company or a company that was previously a Group Company as the case may be is liable to account for tax or social security contributions (in any jurisdiction)   by virtue of the exercise, release or cancellation of the Option for which  an  Optionholder is liable or has agreed to pay, that or any other Group Company or the trustee of any trust which is intended to be an employee share scheme pursuant to  Section 743 of the Companies Act 1985  may:

		
	(a)
	withhold the appropriate amount of tax or social security from the Optionholder's remuneration; or

		
	(b)
	make such other arrangements as it considers necessary (including the sale  of  Shares on behalf of the Optionholder) to finance the amounts in (a)  above,

unless the Optionholder discharges the liability himself at or prior to the date of  exercise.
		
	7.7
	Shares allotted under this Scheme shall rank pari passu in all respects with the Shares    of the same class for the time being in issue save as regards any rights attaching to such Shares by reference to a record date prior to the date of allotment and in the case of a transfer of existing Shares the transferee shall not acquire any rights attaching to such Shares by reference to a record date prior to the date of such  transfer.

		
	7.8
	If and so long as the Shares are listed on the London Stock Exchange or any similar exchange, the Company shall apply for any Shares allotted under this Scheme to be admitted to the Official List or any similar list as the case may be.

		
	7.9
	The exercise of any Option (in whole or in part) shall not be permitted unless the Directors are satisfied at the relevant time that all conditions relating to such exercise pursuant to the Agreement and/or these Rules have  been  met and (if then applicable) that such exercise would not be in breach of the Model Code  for  Securities  Transactions by Directors of Listed Companies published by the UK Listing Authority, any other applicable laws, codes or regulations relating to the acquisition of securities,   or the internal code of the Company.

		
	8.
	TAKEOVERS AND LIQUIDATIONS

		
	8.1
	If the Directors conclude in their discretion that an Exit Event will occur, they may (subject to their not breaching any confidentiality undertakings), determine that the Option shall Vest prior to the expected date of the Exit Event and notify the Optionholder in writing of this and of a period during which the Optionholder may exercise his Option conditionally upon the Exit Event occurring.  Such period must  be:

		
	(a)
	of such reasonable length as will enable the Optionholder to make the necessary arrangements in order to exercise the Option;  and

		
	(b)
	a period commencing on such date as the Directors determine and ending on the  date of the Exit 

Event  or if the Exit Event does not occur, the date that Directors   no longer anticipate an Exit Event  occurring.
		
	8.2
	If the Exit Event anticipated in Rule 8.1 does not occur, the Directors shall, as soon as    is reasonably practicable notify the Optionholder in writing. In such circumstances, the Directors shall return to the Optionholder  any remittance for the Exercise Price or any  tax or social security contributions (including Employer’s NIC) relating to such conditional exercise and the Option shall continue to subsist subject to these Rules.

		
	8.3
	If the Exit Event anticipated in Rule 8.1 does occur and the Directors have exercised  their discretion pursuant to Rule 8.1, the Directors may,  in their discretion  determine that unexercised Options shall lapse immediately after the  Exit  Event.  If  such discretion is exercised, the Directors  must notify the Optionholder  of this  in writing  that this is the case at the same time as the notice in Rule 8.1.

		
	8.4
	If any person obtains Control of the Company by any means other than by way of a Qualifying Exchange of Shares, an Option  shall  Vest in full, and may be exercised  upon such change of Control or within six months  thereafter  and for the purposes  of this Rule 8.4 a person shall be deemed to have obtained Control of the Company if he and others acting in concert with him have together obtained Control  of  it.  If  the Option remains  unexercised six months after it became exercisable in    accordance with

this Rule 8.4, the Directors may, in their discretion, determine that unexercised Options shall lapse.  If  such discretion is exercised, the Directors must notify the Optionholder   of this in writing within six months following the change of  control.
		
	8.5
	If, under Section 425 of the Companies Act 1985, the Court sanctions a compromise or arrangement proposed for the purposes of or in connection with a scheme for the reconstruction of the Company or its amalgamation with any other company or companies, an Option shall Vest in full and may be exercised upon the  Court  sanctioning such compromise or arrangement or within six months thereafter. If the Option remains unexercised six months after becoming exercisable in accordance with this Rule 8.5, the Option shall lapse.

		
	8.6
	If any person becomes bound or entitled to acquire shares in the Company  under  Sections 428 to 430 of the Companies Act 1985 an Option shall Vest in full and may   be exercised at any time when that person remains so bound or  entitled.

		
	8.7
	If the Directors in their absolute discretion so determine, in the event that the Company gives notice to its shareholders of a meeting at which a resolution for the voluntary winding up of the Company (“Winding Up Resolution”) is to be proposed,  the  Company may also give notice to such Optionholders as the Directors shall select and any Options in respect of which such notices have been received will Vest on the date    of the passing of the Winding up Resolution and may be exercised prior to the passing  of the Winding Up Resolution, but conditionally on its being passed, to the intent that they will  be entitled to share in the assets of the Company with the other shareholders   on the same basis as if they had been the registered holders of the relevant Shares immediately prior to the passing of the Winding Up 

Resolution. If the Options remain unexercised on the passing of the Winding Up Resolution, the Options shall   lapse.
		
	9.
	EXCHANGE OF OPTIONS ON A TAKEOVER

		
	9.1
	Notwithstanding Rule 8, if any company (“the  Acquiring Company”) obtains Control    of the Company as a result of:

		
	(a)
	making a general offer to acquire the whole of the issued ordinary share capital of the Company which is made on a condition such that if it is satisfied the person making the offer will have Control of the Company;  or

		
	(b)
	making a general offer to acquire all the shares in the Company which are of the same class as the Shares; or

		
	(c)
	any of the circumstances in Rules 8.5 or 8.6; or

		
	(d)
	a Qualifying Exchange of  Shares,

any Optionholder, with the agreement of the Acquiring Company may, at  any time whilst the Option is outstanding, agree to release his Option (the “Old Option”) in consideration of the grant to him of either a Replacement  Option or a New Option as  the case may be which is equivalent to the Old Option. Such agreement will be conditional upon the change of Control of the Company taking  place.
		
	9.2
	An option granted pursuant to Rule 9.1 above shall only qualify as a Replacement  Option if the requirements of Rule 9.1 above are met, and:

		
	(a)
	the Option is granted to the holder of the Old Option by reason of his employment:

		
	(i)
	with the Acquiring Company;  or

		
	(ii)
	if the Acquiring Company is a parent company, with  the  Acquiring  Company or a member of the Acquiring Company’s  group;

		
	(b)
	at the time of the release of rights under the Old Option, the requirements  of:

(i)paragraph 4 of Schedule 5 (purpose of granting the option);  and
(ii)paragraph 7 of Schedule 5 (company limits) are met in relation to the Replacement  Option;
		
	(c)
	at that time, the independence  requirement  and  the trading activities  requirement as set out in paragraphs 9 and 13 respectively of Schedule 5 are met in relation to the Acquiring Company;

		
	(d)
	at that time, the individual to whom the Replacement Option is granted is an  Eligible Employee in relation to the Acquiring   Company;

		
	(e)
	at that time, the requirements of Part 5 of Schedule 5 are met in relation to the Replacement Option;

		
	(f)
	the total Market Value, immediately before the release, of the Shares which were  subject to the Old 

Option is equal to the total Market Value, immediately after the grant of the Replacement Option, of the shares in  respect  of  which  the Replacement Option is  granted;
		
	(g)
	the total amount payable by the Eligible Employee for the acquisition of Shares    in pursuance of the Replacement Option is equal to the total amount that would have been payable for the acquisition of Shares in pursuance of the Old Option; and

		
	(h)
	The Replacement Option is granted within six  months  of  the  Acquiring Company obtaining Control of the  Company.

		
	9.3
	A New Option shall be an Unapproved  Option.

		
	9.4
	Unless the Directors shall in their absolute discretion decide otherwise where an Old Option is released pursuant to Rule 9.1 any conditions imposed by the  Directors  pursuant to Rule 3 shall not lapse forthwith.

		
	9.5
	Where a Replacement Option or a New Option is granted pursuant to Rule 9.1 it shall   be regarded for the purposes of the subsequent application of the provisions of this Scheme as having been granted at the time when the corresponding Old Options were granted and with effect from the date on which the New Option or Replacement Option is granted:

		
	(a)
	save for the definition of “Group Company” in Rule 1, references to “the Company” (including the definition in Rule 1) shall be construed as being references to  the Acquiring Company to  whose shares the Replacement Option  or New Option as the case may be relates;  and

		
	(b)
	references to “Shares” (including the definition in Rule 1) shall be construed as being references to shares in the Acquiring Company to which the Replacement Option or New Option as the case may be  relates.

		
	10.
	VARIATION OF SHARE CAPITAL

		
	10.1
	In the event of any capitalisation, rights issue, consolidation, subdivision, reduction or other variation of the share capital of the  Company:

		
	(a)
	the number of Shares comprised in an  Option;

		
	(b)
	their Exercise Price in respect of such Shares;  and

		
	(c)
	where an Option has been exercised pursuant to the provisions of these Rules   but no Shares have been allotted or transferred in satisfaction of such exercise, the number of Shares to be so allotted or transferred and the Exercise Price in respect of such Shares,

shall, subject where necessary to the prior approval of the Inland Revenue, be varied in such manner as the Directors shall determine and (save in the event of a capitalisation) the Auditors shall confirm in writing to be in their opinion  fair  and  reasonable,  provided that, except as provided in Rules 10.2 and 10.3, no variation shall be made which would result in the Exercise Price for an allotted Share being less  than  its  nominal value.
		
	10.2
	Any adjustment made to the Exercise Price of unissued Shares which would have the effect of reducing 

the Exercise Price to less than the nominal value of the Shares shall only be made if and to the extent that the Directors are authorised to capitalise from the reserves of the Company a sum equal to the amount by which the nominal value of the Shares in respect of which the Option is exercisable exceeds  the adjusted  Exercise  Price. The Directors may apply such sum in paying up such amount on such Shares so that on the exercise of any Option in respect of which such a reduction shall have been made, the Directors shall capitalise such sum (if any) and apply the same in paying up such amount as  aforesaid.
		
	10.3
	Where an Option subsists over both issued and unissued Shares,  an adjustment  may  only be made under Rule 10.2 if the reduction of the Exercise Price in relation to  Options over both issued and unissued Shares can be made to the same  extent.

		
	10.4
	The Directors may take such steps  as  they consider  necessary to  notify Optionholders of any adjustment made under this Rule 10 and to call in, cancel, endorse, issue or re- issue any Agreement consequent upon such  adjustment.

		
	11.
	ADMINISTRATION

		
	11.1
	The Directors shall have power from time to time to make and vary such  regulations  (not being inconsistent with this Scheme) for the implementation and administration of this Scheme and/or the Agreement as they think  fit.

		
	11.2
	The decision of the Directors shall be final and binding in all matters relating to this Scheme (other than in the case of matters to be determined or confirmed by  the  Auditors in accordance with this  Scheme).

		
	11.3
	The costs of establishing and administering this Scheme shall be borne  by  the  Company.

		
	11.4
	The Company may, but shall not be obliged to, provide Eligible Employees or Optionholders with copies of any notices circulars or other documents sent to shareholders of the Company.

		
	11.5
	Within 92 days (or such longer period as may from time to time be permitted by the  EMI Code) of granting an EMI Option under this Scheme notice shall be given to the Inland Revenue by the Employer Company and shall   contain:

		
	(a)
	information required by the Inland Revenue pursuant to paragraph 44  of  Schedule 5;

		
	(b)
	a declaration from a director or the Company Secretary of the Employer  Company, that in his opinion the requirements of Schedule 5 have been met in relation to an EMI Option under this Scheme and that to the best of  his  knowledge, the information provided is correct and complete;   and

		
	(c)
	a declaration from the Optionholder to whom the EMI Option is granted that he meets the Committed Time  requirement.

		
	12.
	AMENDMENTS

		
	12.1
	Notwithstanding Rule 12.2, if the Inland Revenue raise a notice of enquiry pursuant to paragraph 46 of 

Schedule 5 and conclude that the requirements of the EMI Code have not been met in relation to this Scheme and/or the Agreement (as the case may be) the Directors may alter the Rules of this Scheme and/or any Agreement as may  be  necessary to ensure that the requirements of the EMI Code have been met.
		
	12.2
	The Directors, in their absolute discretion, may waive or amend any of these Rules or introduce such new rules as they see fit provided that any amendments   to:

		
	(a)
	the definition of Eligible  Employee;

		
	(b)
	the limits on the maximum number of Shares which may be issued under the Scheme;

		
	(c)
	the basis for determining an Optionholder’s entitlement to Shares under the Scheme and the terms of those Shares;  and

		
	(d)
	the basis on which an Option may be adjusted if there is a variation of capital pursuant to Rule 10,

which are to the advantage of existing or future Optionholders may not  be  made without approval of the members of the Company in a General   Meeting.
		
	12.3
	Notwithstanding Rule 12.2, the Directors may amend the provisions of this Scheme and/or Agreement and the terms of any Options as they consider necessary or desirable  in order to:

		
	(a)
	make the administration of this Scheme more effective or easier;

		
	(b)
	comply with or take account of the provisions of any proposed or existing legislation;

		
	(c)
	take account of any of the events mentioned in Rule 8 (takeover etc);   or

		
	(d)
	obtain or maintain favourable tax or  regulatory treatment  for  the  Company or any Group Company or any  Optionholder,

without the need for the prior approval of the Company in General Meeting or the consent of Optionholders provided that such amendments or additions do not affect the basic principles of this Scheme and/or  Agreements.
		
	12.4
	Written notice of any amendment to this Scheme shall be given to all Optionholders affected thereby.

		
	13.
	GENERAL

		
	13.1
	A Group Company or a company that was previously a Group Company as  the case  may be may provide money to the Trustee to enable them to subscribe for or purchase Shares for the purposes of the Scheme or enter into any guarantee or indemnity for these purposes to the extent permitted by Section 153 of the Companies Act   1985.

		
	13.2
	The Directors may grant an Option to the Trustee to subscribe for Shares or  issue  Shares to the Trustee or to its order provided that the Trustee agree to use such Shares  to satisfy the exercise of Options granted pursuant to the  Scheme.

		
	13.3
	Any Shares issued pursuant to options granted or Shares issued to the Trustee shall be included in the limits on the number of Shares available to the Scheme under Rule 5.1 above.

		
	13.4
	This Scheme shall commence upon the date the Directors adopt this Scheme and shall terminate on the expiry of the period of ten years from such date. On termination no further Options may be granted but such termination shall be without prejudice to any accrued rights in existence at the date  thereof.

		
	13.5
	The Company will at all times keep available sufficient  authorised  and  unissued  Shares, or shall ensure that sufficient Shares will be available, to satisfy the exercise to the full extent still possible of all Options not lapsed pursuant to the provisions of these Rules, taking account of any other obligations of the Company to issue  Shares.

		
	13.6
	Notwithstanding any other provision of this   Scheme:

		
	(a)
	this Scheme shall not form part of any contract of employment between  any  Group Company or a company that was previously a  Group  Company as  the  case may be and any employee or officer of any such company and the rights   and obligations of any individual under the terms of his office or employment with  any Group Company or a company that was previously a Group Company as the case may be shall not be affected by his participation in this Scheme or any right which he may have to participate in it and this Scheme shall afford such an individual no additional rights to compensation or damages in consequence of    the termination of such office or employment for any reason whatsoever,  including if such termination of employment was lawful or   unlawful;

		
	(b)
	no Optionholder shall be entitled to any compensation or damages for any loss or potential loss which he may suffer by reason of being unable to exercise an Option in consequence of the loss or termination of  his  office or  employment with any Group  Company or a  company that was previously a Group Company  as the case may be for any reason whatsoever including if such termination of employment was lawful or unlawful;  and

		
	(c)
	this Scheme shall not confer on any person any legal or equitable rights (other  than those constituting the Options themselves) against any Group Company or a company that was previously a Group Company as the case may be directly or indirectly, or give rise to any cause of action at law or  in equity against  any  Group Company or a company that was previously a  Group  Company as  the  case may be.

		
	13.7
	Save as otherwise provided in this Scheme any notice or communication to be given by the Company or Grantor as the case may be to any Eligible Employee or Optionholder may be personally delivered or sent by fax or by ordinary post to his last  known  address. Where a notice or communication is sent by post it shall be deemed to have  been received 48 hours after the same was put into the post properly addressed and stamped and where a notice or communication is sent by fax it shall be deemed to have been received at the time when it was sent. Share  certificates  and  other  communications sent by post will be sent at the risk of the Eligible Employee or Optionholder concerned and the Company or Grantor as the case may be shall have no liability whatsoever to any such person in respect of any notification, 

document, share certificate or other communication so given, sent or  made.
		
	13.8
	Any notice to be given to the Company shall be delivered or sent by either post or fax    to the Company at its registered office and shall be effective upon  receipt.

		
	13.9
	This Scheme and all Options granted under it shall be governed by and construed in accordance with English  law.Exhibit

aCertain identified information has been marked in the exhibit because it is both (i) not material and 
(ii) would likely cause competitive harm to the Company, if publicly disclosed.
Double asterisks denote omissions.

Exhibit 4.24

	
											
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT
	CONTRACT ID CODE
	PAGE  OF  PAGES
     1                 5

	2.AMENDMENT/MODIFICATION NO.
P00004
	3.EFFECTIVE DATE
See Block 16C 
	4.REQUISITION/PURCHASE REQ. NO.
OS241948
	5.PROJECT NO. (If applicable)

	6.ISSUED BY                                              CODE
	ASPR-BARDA
	7.ADMINISTERED BY (If other than Item 6)                                                              
                                                          CODE
	ASPR-BARDA02

	

ASPR-BARDA
O’NEILL HOUSE OFFICE BUILDING
Room 21B05
Washington DC 20515

	        US DEPT OF HEALTH & HUMAN SERVICES
ASPR AMCG
O’NEILL HOUSE OFFICE BUILDING
Room 21B05
        Washington DC 20515

	8.NAME AND ADDRESS OF CONTRACTOR (No., Street, City, County, State and ZIP Code)

SUMMIT (OXFORD) LIMITED 1510803
Attn: [**]
136A EASTERN AVENUE
MILTON PARK
ABINGDON OXFORDSHIRE OX14 4SB
	(x)
	9A.AMENDMENT OF SOLICITATION NO.

	 

	9B.DATED (SEE ITEM 11)

	x
	10A.MODIFICATION OF CONTRACT/ORDER NO.
HHSO100201700014C

	10B.DATED (SEE ITEM 13)

09/05/2017

	CODE      1510803
	FACILITY CODE

	11. THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

	The above solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers                 ̈ is extended.     ̈ is not extended.                  Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning                    copies of the amendments; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers. FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT THE PLACE DESIGNATED FOR THE RECEIPT OF THE OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes reference to the solicitation and this amendment and is received prior to the opening hour and date specified.

	12.ACCOUNTING AND APPROPRIATION DATA (If required)                     Net Increase:                           $9,621,496.00
2019.1992019.25106

	13.THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	CHECK ONE
	A. THIS CHANGE ORDER IS ISSUED PURSUANT TO: (Specify authority) THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

	 

	 
	B. THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43 103(b).

	X
	C. THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:
FAR 43.103 (a) (3) Mutual Agreement of the Parties

	 
	D. OTHER (Specify type of modification and authority)

	E. IMPORTANT:    Contractor           ̈ is not       x is required to sign this document and return 2 copies to the issuing office.

	14. DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings including solicitation/contract subject matter where feasible.)
Tax ID Number: CO-0000487
DUNS Number:733628718
The Purpose of this Modification is to (1) award Option 1 (CLIN 2) at a new figure for BAARDA contribution of $9,621,496 and (2) change the statement of Work.
FUNDS ALLOTTED PRIOR TO THIS MODIFICATION    $43,967,000.00
FUNDS ALLOTTED WITH THIS MODIFICATION:             $9,621,496.00
FUNDS ALLOTTED TO DATE:                                         $53,597,496.00
PERIOD OF PERFORMANCE:     SEPTEMBER 5, 2017 TO APRIL 30, 2022

Continued...
Except as provided herein, all terms and condition of the document referenced in Item 9A or 10A, as heretofore changes, remains unchanged and in full force and effect.

	15A.NAME AND TITLE OF SIGNER (Type or print)
MELISSA STRANGE, VP FINANCE
	16A.NAME OF CONTRACTING OFFICER (Type or print)
JAMES P. BOWERS

	15B.NAME OF CONTRACTOR
SUMMIT (OXFORD) LIMITED

BY /s/Melissa Strange____________________
(Signature of person authorized to sign)
	15C.DATE SIGNED

17 JUN 2019
	16B.UNITED STATES OF AMERICA

BY /s/ James P. Bowers______________
(Signature of Contracting Officer)
	16C.DATE SIGNED

17 JUN 2019

	NSN 7540-01-152-8070
Previous edition is NOT usable
	STANDARD FORM 30 (REV. 10-83)
Prescribed by GSA 
FAR (48 CFR) 53.243

	
								
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201700014C/P0004
	PAGE 2 OF 2  

	NAME OF OFFEROR OR CONTRACTOR
SUMMIT (OXFORD) LIMITED   1510803

	ITEM NO.

(A)
	SUPPLIES/SERVICES

(B)
	QUANTITY

(C)
	UNIT

(D)
	UNIT PRICE

(E)
	AMOUNT

(F)

	

2
	     See Continuation Sheet
Delivery: 06/13/2019
Delivery Location Code:  HHS/OS/ASPR
HHS/OS/ASPR
200 C St SW
WASHINGTON DC 20201 US

Appr. Yr.: 2019 CAN:  1992019 Object Class:  25106
    Period of Performance:  09/05/2017 to 04/30/2022

Change Item 2 to read as follows (amount is the obligated amount:
Option 1: [**]

	

	

	

	

9,621,496.00

	NSN 7540-01-152-8067
	OPTIONAL FORM 336 (4-86)
Sponsored by GSA
FAR (48 CFR) 53.110

	
			
	Contract No.
HHSO100201700014C
Modification No. 0004
	Summit (Oxford) Ltd.
Continuation Sheet

Beginning with the effective date of this modification, the Government and the Contractor mutually agree to exercise Option 1 (CLIN 2) as follows:
		
	A.  
	In accordance with the changes that come into effect due to the exercising of option one (1) the following sections are changed:

		
	1.
	ARTICLE B.2 ESTIMATED COST,

2.  The Governmental shall provide monies for the base period segment (CLIN 001) in an amount not to exceed $31,967,000.  The Contractor's share of the Base Period is estimated at $[**].  The Government will provide monies for the Option 2 period segment (CLIN 0003) in an amount not to exceed $12,000,000.  And the Government will provide funding for the Option 1 segment (CLIN 0002) in an amount not to exceed $9,621,496. The Government will not be responsible for any Contractor incurred costs that exceed these amounts unless a modification to the contract is signed by the Contracting Officer which expressly increases the amount.  The Contractor's share of the Option 1 period segment (CLIN 0002) is estimated at $[**].
5.  It is estimated that the amount currently allotted will cover performance of the Base period through July 1, 2019; of Option 1 through [**] and of Option 2 through [**].
	
							
	CLIN
	Period of Performance
	Supplies/Services
	Government Share
	Contractor Share
	Total
Cost
	Status

	Base/
CLIN
0001
	Sept 5, 2017
Through
June 30,
2019
	[**]
	$31,967,000
	$[**]
	$[**]
	Executed

	Option 1/
CLIN
0002
	[**], 2019
Through
[**]
2022
	[**]
	$9,621,496
	$[**]
	$[**]
	Executed

    

	
			
	Contract No.
HHSO100201700014C
Modification No. 0004
	Summit (Oxford) Ltd.
Continuation Sheet

	
							
	CLIN
	Period of Performance
	Supplies/Services
	Government Share
	Contractor Share
	Total
Cost
	Status

	Option 2/
CLIN
0003
	[**], 2018
Through
[**]
2022
	[**]
	$12,000,000
	$[**]
	$[**]
	Executed

1.    ARTICLE B.3. OPTION PRICES

		
	a.  
	Unless the Government exercises its option pursuant to FAR Clause 52.217-9 (Option to Extend the Term of the Contract), contained in ARTICLE 1.2, the contract consists only of the base period (CLIN 0001), Option 1 (CLIN 0002) and Option 2 (CLIN 0003) specified in the Statement of Work as defined in SECTIONS C and F, for the price set forth in ARTICLE B.2 of the contract.

		
	b.  
	Pursuant to FAR Clause 52.217-9 (Option to Extend the Term of the Contract), the Government may, by unilateral contract modification, require the contractor to perform the remaining Option Work Segments specified in the Statement of Work as defined in SECTIONS C and F of this contract. If the Government decides to exercise an option(s), the Government will provide the Contractor a preliminary written notice of its intent to exercise the option at least [**] days before the contract expires. If Option 3 CLIN 0004 is exercised, the estimated cost of the contract will be increased as set forth in the table below:

	
							
	 
	 
	 
	 
	 
	 
	 

	Option
3/CLIN
0004
	[**] through [**], 2022
	[**]
	$[**]
	$[**]
	$[**]
	Not Executed

	 
	TOTAL
	 
	$63,743,173
	$[**]
	$[**]
	 

	
			
	Contract No.
HHSO100201700014C
Modification No. 0004
	Summit (Oxford) Ltd.
Continuation Sheet

B. Under SECTION B (SUPPLIES OR SERVICES and PRICES/COSTS), ARTICLE B.4 (Provisions Applicable to Direct Costs), paragraph b (Travel Costs), is deleted and replaces as follows:

b.    Travel Costs
		
	1.
	The Government is not responsible for the travel portion of the Base Period segment (CLIN 0001), the Option 1 period (CLIN 0002) and the Option 2 period (CLIN 003). 

C.    Under SECTION F, ARTICLE F.2, DELIVERABLES the first paragraph is deleted and replaced as follows:
Successful performance of the final contract shall be deemed to occur upon completion of performance of the work set for in the Statement of Work dated April 9, 2019 set forth in SECTION J - List of Attachments of this contract and upon delivery and acceptance, as required by the Statement of Work, by the Contracting Officer, of each of the deliverables described in SECTION C, SECTION F, and SECTION J.
G.    Under SECTION J - LIST OF ATTACHMENTS, delete ATTACHMENT 1, Statement of Work dated February 4, 2019 (5 pages) and replace with Statement of Work dated April 9, 2019 (5 pages).
END OF MODIFICATION 0004 TO HHSO100201700014C

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