Document:

EX-10.1

 Exhibit 10.1 

11/21/14 
 FIRST
AMENDMENT TO LEASE 
 THIS FIRST AMENDMENT TO LEASE (hereinafter referred to as the “Amendment”) is dated as of this 21st day
of November, 2014 by and between FOREST CITY 88 SIDNEY, LLC, a Delaware limited liability company (“Landlord”) and AGIOS PHARMACEUTICALS, INC., a Delaware corporation (“Tenant”). Capitalized terms used herein and not otherwise
defined shall have the meaning ascribed to such term in the Lease. 
 W I T N E S S E T H 

WHEREAS, Landlord and Tenant entered into that certain Lease dated as of September 15, 2014 (the “Lease”) with respect to
certain premises located at 88 Sidney Street, Cambridge, Massachusetts (the “Premises”); and 
 WHEREAS, Landlord and Tenant
desire to amend the Lease to expand the definition of Premises, modify the Landlord’s Work, provide for an additional improvement allowance, and for other purposes, as set forth in this Amendment. 

NOW, THEREFORE, in consideration of the promises and mutual covenants hereinafter contained and other valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 
  

	1.	Premises. Effective as of the date hereof, the term “Premises” set forth on Exhibit A of the Lease is deleted in its entirety and replaced with the following: 

“Premises: The Premises shall be comprised of approximately 113,218 rentable square feet as follows: 

 

			
	 Floor 1 Suite 100A:
	  	418 rsf
	 Floor 1 Suite 100B:
	  	340 rsf
	 Floor 1 Suite 100:
	  	7,086 rsf
	 Floor 1 Suite 150:
	  	4,928 rsf
	 Floor 2 Suite 200:
	  	33,452 rsf
	 Floor 3 Suite 300:
	  	33,464 rsf
	 Floor 4 Suite 400:
	  	33,530 rsf

 All as more particularly shown on the floor plans attached to this Lease as Exhibit B.” 

 

	2.	Annual Fixed Rent. Effective as of the date hereof, the term “Annual Fixed Rent for the Term” set forth on Exhibit A of the Lease is deleted in its entirety and replaced with the following:

 “Annual Fixed Rent: With respect to Suite 100A, Suite 100, Suite 300 and Suite 400: $57.25 per rsf, as adjusted per the
terms of Section 3.1 hereof. With respect to Suite 100B, Suite 150 and Suite 200: $60.00 per rsf, as adjusted per the terms of Section 3.1 hereof.” 

  
 - 1 - 

	3.	Condition of Premises. Section 2.1 (b) shall be amended to add the following as (iii) and (iv) thereof: 

“,(iii) demolish and dispose of the existing improvements currently located in the two GMP suites located on the second floor and deliver
the suite areas to Tenant in shell condition; and (iv) remove the existing RODI system in the Premises.” 
  

	4.	Common Corridors. The first sentence of Section 2.1 (c) (ii) shall be amended by adding the words “in accordance with Exhibit B-l attached hereto” at the end thereof.

  

	5.	Shared Laboratory Systems. Section 2.3(c) of the Lease shall be amended by deleting the reference to “RODI” in the second line thereof. 

 

	6.	PH Neutralization. Section 2.3(d) shall be deleted in its entirety and replaced with the following: 

“(d) Tenant has the option to either (i) utilize the Building’s modified PH neutralization system (as described in the sentence
below), or (ii) install a new PH neutralization system at Tenant’s sole cost and expense. Concurrent with Tenant’s Work, Landlord, at Landlord’s cost and expense, shall modify the Building’s existing PH neutralization system
for the dedicated sole use by Tenant. Landlord shall demise the PH neutralization system so that it is serving only the Premises and deliver said system to Tenant in good operating condition and repair. In the event Tenant elects to install a new PH
neutralization system, Landlord shall provide, at no cost to Tenant, a dedicated space for the new system in the First Floor Mechanical Space. Landlord shall provide Tenant with a contribution in the amount of One Hundred Thousand and 00/100 Dollars
($100,000.00) to be used by Tenant in connection with either option.” 
  

	7.	Annual Fixed Rent; Annual Increases. Section 3.1 shall be amended by deleting the second paragraph thereof and replacing it with the following: 

“On the first anniversary of the Rent Commencement Date, and on each anniversary thereafter, Annual Fixed Rent for Suites 100A, 100, 300
and 400 shall increase to an amount equal to one hundred two percent (102%) of the Annual Fixed Rent immediately preceding such anniversary. On the first anniversary of the Rent Commencement Date, and on each anniversary thereafter, Annual
Fixed Rent for Suites 150 and 200 shall increase to an amount equal to one hundred three percent (103%) of the Annual Fixed Rent immediately preceding such anniversary.” 

 

	8.	Tenant/Landlord Matrix and Lobby Renovation Plans. Exhibit H shall be deleted and replaced with a new Exhibit H attached hereto. 

 

	9.	Leasehold Improvement Allowance. The defined term “Leasehold Improvements Allowance” set forth on Exhibit A shall be amended by deleting “$11,174,700.00” and replacing it with
“$16,189,047.00”. 

  
 - 2 - 

	10.	Parking Privileges. The first sentence of the term “Parking Privileges” set forth on Exhibit A shall be deleted in its entirety and replaced with the following: 

“During the Term, Tenant shall be entitled to use and shall pay for one hundred sixty-nine (169) parking passes in accordance with
Section 2.4 of the Lease; provided, however, that during the first twelve (12) months of the Term, Tenant shall have the option to use and pay for a minimum of one hundred fifty-two (152) parking passes.” 

 

	11.	Additional Leasehold Improvement Allowance. Landlord shall provide to Tenant an additional allowance (the “Additional Leasehold Improvement Allowance”) in the amount of Three Hundred Thousand and 00/100
Dollars ($300,000.00) (which amount represents a 50% share of the savings in demising costs relating to the first and second floor, based on an agreement between Landlord and Tenant), to be used by Tenant together with the Leasehold Improvements
Allowance for application to the costs and expenses incurred by or on behalf of Tenant in connection with improvements to the Premises as referenced in Exhibit E, to be applied and disbursed in accordance with the terms of the Lease and on the same
terms and conditions as the Leasehold Improvements Allowance. All references in the Lease to the Leasehold Improvements Allowance shall refer to the Leasehold Improvements Allowance together with the Additional Leasehold Improvements Allowance.

  

	12.	Security Deposit. The defined term “Security Deposit” set forth on Exhibit A shall be amended by deleting “$ 1,421,670.17” and replacing it with “$2,189,270.17”. Within thirty
(30) days of the execution of this Amendment, Tenant shall deposit Seven Hundred Sixty-Seven Thousand Six Hundred and 00/100 Dollars ($767,600.00) with the Landlord as an additional Security Deposit, so that the total amount of the Security
Deposit set forth on Exhibit A shall be Two Million One Hundred Eighty-Nine Thousand Two Hundred Seventy and 17/100 Dollars ($2,189,270.17). At Tenant’s election, such increase in the Security Deposit shall be effectuated by a substitution of a
single new Letter of Credit. 

  

	13.	Modified Right of First Refusal. Section 2.9 of the Lease is revised as follows: 

  

	 	a.	Pursuant to the terms of first paragraph of Section 2.9, Landlord’s MROFR Notice shall set forth the Material Economic Terms in the Active Negotiations upon which Landlord is prepared to lease the Modified
First Refusal Space to Tenant. 

  

	 	b.	Tenant’s right to exercise the MROFR shall be on the terms set forth in the Landlord’s MROFR Notice on the Material Economic Terms in the Active Negotiations, adjusted however in order to make the term
coterminous with the existing Term of the Lease, as set forth below: 

  

	 	(i)	There shall be a corresponding adjustment to either (A) the Annual Fixed Rent or (B) the amount of the Leasehold Improvements Allowance to be provided, such that the average Annual Fixed Rent (including any
increases) due Landlord over the Term of the Lease, less the amortization (at an interest rate of eight percent (8%)) of any Leasehold Improvements Allowance under the adjusted Term are equivalent to the average Annual Fixed Rent (including any
increases) less the amortization (at an interest rate of eight percent (8%)) of any Leasehold Improvements Allowance that Landlord would have received under the Term in accordance with the Material Economic Terms of the Active Negotiations set
forth in the Landlord’s MROFR Notice. 

  
 - 3 - 

	 	(ii)	If, in order to be coterminous with the existing Term of the Lease, the term for the Modified First Refusal Space needs to be adjusted to be shorter than the term set forth in the Landlord’s MROFR Notice, Tenant
shall have the right to elect whether to have the Leasehold Improvement Allowance decreased, or to have the rental rate increased, in accordance with the foregoing subsection. 

 

	 	(iii)	If, in order to be coterminous with the existing Term of the Lease, the term for Modified First Refusal Space needs to be adjusted to be longer than the term set forth in the Landlord’s MROFR Notice, the same
process shall be applied either (A) to increase the Leasehold Improvement Allowance, or (B) to decrease the applicable Annual Fixed Rent at the option of Tenant, and the corresponding adjustment of the Leasehold Improvement Allowance or
the Annual Fixed Rent shall be made in the same manner as provided in subsection (i) above; 

  

	 	  	provided, however, if the Leasehold Improvement Allowance proposed in the Material Economic Terms is in excess of $80.00 per rentable square foot, Tenant shall have the right (x) to reduce the Leasehold Improvement
Allowance for such Modified First Refusal Space (but in no event less than $80.00 per rentable square foot), and (y) to reduce the Annual Fixed Rent allocable to such space, and the corresponding adjustment of Annual Fixed Rent shall be made in
the same manner as provided in subsection (i) above. In the event Tenant exercises its right to reduce the Leasehold Improvement Allowance for the Modified First Refusal Space to no less than $80.00 per rentable square foot, Landlord, at
Landlord’s sole discretion, shall have the option to modify the adjustment to the Material Economic Terms set forth in the Landlord’s MROFR Notice to, instead of reducing the Annual Fixed Rent rate as provided in subsection (y) above,
to provide for an initial period of $0 Annual Fixed Rent (ie “free rent” periods) so long as the net effective terms of such adjustments are the same as proposed in the Landlord’s MROFR Notice. 

 

	 	c.	The Landlord’s MROFR Notice shall set forth accurately the Material Economic Terms of the Active Negotiations. In addition, Landlord shall set forth Landlord’s calculation of the adjustment to provide the same
“net effective terms” as set forth above and to make the Lease coterminous for the Modified First Refusal Space. 

  
 - 4 - 

	14.	Solvent Storage. Section 11.17 of the Lease shall be amended by adding the following sentence at the end thereof: 

“Notwithstanding the foregoing, Tenant shall, within sixty (60) days of written request from Landlord and at Landlord’s sole
discretion, relinquish to Landlord a portion of Tenant’s allocation of solvent storage on the first floor of the Building in an amount up to 120 gallons of liquid solvents. Tenant shall be responsible for any required modification to their
existing permits or licenses for solvent storage, and shall provide Landlord with copies of any such modified permits or licenses.” 
  

	15.	Floor Plans Showing Premises. Exhibit B to the Lease shall be deleted and replaced with a new Exhibit B attached hereto 

  

	16.	Common Corridor Plan. Exhibit B-l attached hereto shall be incorporated into the Lease as Exhibit B-l thereto and shall be referenced as the Building Lobby, Elevator Lobby, and Egress Corridor Plan.

  

	17.	Counterparts. This Amendment may be executed in any number of counterparts, each of which shall be deemed an original and all of which together shall constitute one and the same instrument. 

 

	18.	Brokers. Landlord and Tenant represent and warrant that they have had no dealings with any broker or agent in connection with this Amendment other than Colliers International New England, LLC and CBRE/New England
and each party shall indemnify and hold harmless the other party from claims for any brokerage commission. Landlord shall pay Colliers International New England, LLC and CBRE/New England a brokerage commission pursuant to the terms of a separate
agreement. 

  

	19.	Ratification. The Lease, as amended hereby, is in full force and effect, and is ratified and confirmed, and there are no other amendments or modifications thereto. 

 

	20.	Governing Law. This Amendment will be governed by and construed in accordance with the laws of the Commonwealth of Massachusetts. 

 

	21.	Ground Lessor. This Amendment shall be subject to the prior written consent of the Ground Lessor, The Massachusetts Institute of Technology, and Landlord will use good faith best efforts to obtain such consent.

  

	22.	Due Authority. Each of Landlord and Tenant, for itself, warrants and represents that this Amendment is its duly adopted, approved and authorized act and that the person signing this Amendment has full authority
to bind, and to execute this Amendment on behalf of, the party he or she represents. 

  
 - 5 - 

 IN WITNESS WHEREOF, the parties hereto have executed this Amendment under seal, as of the day, month and year
first above written. 
  

									
	LANDLORD:
	
	 Forest City 88 Sidney, LLC,
 a
Delaware limited liability company

		
	By:	 	FC HCN 88 Holding, LLC,
		 	 a Delaware limited liability company,

Its sole member

			
		 	By:	 	 FC HCN University Park, LLC,
 a
Delaware limited liability company,
 Its sole member

				
		 		 	By:	 	 Forest City University Park, LLC,
 a
Delaware limited liability company
 Its managing member

					
		 		 		 	By:	 	 /s/ Michael Farley

		 		 		 	Name:	 	Michael Farley
		 		 		 	Its:	 	Vice President

  

			
	TENANT:
	
	 AGIOS PHARMACEUTICALS, INC.,
 a
Delaware corporation

		
	By:	 	 /s/ David Schenkein

	Name:	 	David Schenkein
	Title:	 	CEO AGIOS

  
 - 6 - 

 EXHIBIT B 

Floor Plans Showing the Premises 

SEE ATTACHED 

  
 - 7 - 

  
 

 

  
 - 8 - 

  
 

 

  
 - 9 - 

  
 

 

  
 - 10 - 

  
 

 

  
 - 11 - 

 EXHIBIT B-l 

Common Corridor Plans 
 SEE
ATTACHED 

  
 - 12 - 

 

 

  
 - 13 - 

 EXHIBIT H 

Tenant/Landlord Matrix and Lobby Renovation Plans 

SEE ATTACHED 

  
 - 14 - 

 Exhibit H 

Agios 
 88 Sidney Street, 1st, 2nd, 3rd & 4th Floor 

Cambridge, MA 
 Tenant / Landlord Responsibility Matrix

 November 20, 2014 
  

									
	 Description
	  	 Landlord
	 	  	 Tenant
	 
	 SITEWORK
	  				  			
	 Telephone service to main demarcation room from local exchange carrier
	  	 	X	  	  			
	 Domestic sanitary sewer connection to street
	  	 	X	  	  			
	 Tenant Dedicated Lab Waste and use of existing PH Neutralization Tanks LL shall demise lab waste piping risers to the leased premises
to facilitate the sole use and operation of the existing PH Neutralization tank by tenant
	  				  	 	X	  
	 Lab waste sewer connection to individual tenant pH neutralization system
	  	 	X	  	  			
	 Roof storm drainage
	  	 	X	  	  			
	 Nstar primary and secondary electrical service
	  	 	X	  	  			
	 Nstar gas service
	  	 	X	  	  			
	 Domestic water service to Building
	  	 	X	  	  			
	 Fire protection water service to Building
	  	 	X	  	  			
	 STRUCTURE
	  				  			
	 Structural enhancements for specific Tenant load requirements
	  				  	 	X	  
	 Structural framing dunnage above roof for Base Building equipment
	  	 	X	  	  			
	 Structural framing dunnage above roof for Tenant equipment (subject to Landlord review and approval).
	  				  	 	X	  
	 Framed openings for Base Building utility risers
	  	 	X	  	  			
	 Framed openings for Tenant utility risers in addition
	  				  	 	X	  
	 Miscellaneous metals items and/or concrete pads for Base Building equipment
	  	 	X	  	  			
	 Control Area Chemical Storage allowance as allocated by the Landlord as from the defined allowable
total
 1st Floor 480 Gallons in Chemical Storage Room 100 A
(per Exhibit B)
 1st Floor 480 Gallons in Solvent Storage Room
100 B (per Exhibit B)
 1st floor 120 Gallon Storage

2nd floor 120 Gallons Storage

3rd floor 120 Gallons Storage

4th floor 60 Gallons Storage

The storage is contingent on the tenants submission and approval of the AHJ Authority Having Jurisdiction
	  	 	X	  	  			
	 Miscellaneous metals items and/or concrete pads for Tenant equipment
	  				  	 	X	  
	 ROOFING
	  				  			
	 Single ply EPDM roofing system with rigid insulation
	  	 	X	  	  			
	 Roofing penetrations for Base Building equipment/systems
	  	 	X	  	  			
	 Roofing penetrations for Tenant equipment/systems by LL’s roofer to LL Spec
	  				  	 	X	  
	 Walkway pads to Base Building equipment
	  	 	X	  	  			
	 Walkway pads to Tenant equipment
	  				  	 	X	  
	 Roofing alterations due to Tenant changes
	  				  	 	X	  

  
 - 15 - 

									
	 EXTERIOR
	  				  			
	 Building exterior consisting of precast concrete and windows
	  	 	X	  	  			
	 Main Building entrances
	  	 	X	  	  			
	 Loading dock with loading dock elevator and stairwell
	  	 	X	  	  			
	 Acoustic screening of Base Building rooftop equipment
	  	 	X	  	  			
	 Acoustic screening of Tenant rooftop equipment (space available within base building screening
	  				  	 	X	  
	 COMMON AREAS
	  				  			
	 Accessible main entrance
	  	 	X	  	  			
	 First floor finished lobby
	  	 	X	  	  			
	 Upper level elevator lobbies on floors with multiple Tenants
	  	 	X	  	  			
	 Core area toilet rooms
	  	 	X	  	  			
	 Janitor’s closets in core areas
	  	 	X	  	  			
	 Primary demarcation room
	  	 	X	  	  			
	 Doors, frames, and hardware at common areas
	  	 	X	  	  			
	 ELEVATORS
	  				  			
	 Three (2) passenger elevators, one (1) service with a capacity of 4,000 lbs.
	  	 	X	  	  			
	 WINDOW TREATMENT
	  				  			
	 Furnish and install Building standard blinds for all windows
	  	 	X	  	  			
	 TENANT AREAS
	  				  			
	 Finishes at inside face of exterior walls
	  				  	 	X	  
	 Finishes at inside face at Tenant side of core partitions
	  				  	 	X	  
	 Toilet rooms within Tenant Premises in addition to those provided by base building
	  				  	 	X	  
	 Electrical closets within Tenant Premises
	  				  	 	X	  
	 Tel/data rooms for interconnection with Tenant tel/data
	  				  	 	X	  
	 Tenant kitchen areas
	  				  	 	X	  
	 Modifications to core areas to accommodate Tenant requirements
	  				  	 	X	  
	 Partitions, ceilings, flooring, painting, finishes, doors, frames, hardware, millwork, casework, equipment, and build out.
	  				  	 	X	  
	 Fixed or movable casework.
	  				  	 	X	  
	 Laboratory Equipment including but not limited to biosafety cabinets, autoclaves, glass washers.
	  				  	 	X	  
	 Chemical Fume Hoods, bench fume hood
	  				  	 	X	  
	 Finishes at corridors on floors with multiple Tenants within redeveloped space
	  	 	X	  	  			
	 Shaft enclosures for Base Building systems’ risers
	  	 	X	  	  			
	 Shaft enclosures for Tenant risers (in addition to risers put in place for tenant use)
	  				  	 	X	  

  
 - 16 - 

									
	 FIRE PROTECTION
	  				  			
	 Fire service entrance including fire department connection, alarm valve, and flow protection
	  	 	X	  	  			
	 Core area distribution piping and sprinkler heads
	  	 	X	  	  			
	 Stair distribution piping and sprinkler heads
	  	 	X	  	  			
	 All run outs, drop heads, and related equipment within Tenant premises
	  				  	 	X	  
	 Modification of sprinkler piping and head locations to suit Tenant layout and hazard index
	  				  	 	X	  
	 Specialized extinguishing systems or containment for tenant program areas
	  				  	 	X	  
	 Preaction dry-pipe systems
	  				  	 	X	  
	 Fire extinguisher cabinets at core common areas
	  	 	X	  	  			
	 Fire extinguisher cabinets in Tenant Premises
	  				  	 	X	  
	 PLUMBING
	  				  			
	 Domestic water service with backflow prevention and Base Building risers
	  	 	X	  	  			
	 Domestic water distribution within Tenant Premises
	  				  	 	X	  
	 Core restroom plumbing fixtures compliant with accessibility requirements and anticipated lab/office occupancy of 1
person/350sf.
	  	 	X	  	  			
	 Tenant restroom plumbing fixtures compliant with accessibility requirements (in addition to those provided by the Base
Building)
	  				  	 	X	  
	 Wall hydrants in common core areas (where required by code)
	  	 	X	  	  			
	 Tenant metering and sub-metering at Tenant connection
	  				  	 	X	  
	 Storm drainage system
	  	 	X	  	  			
	 Sanitary waste and vent service
	  	 	X	  	  			
	 Two stage active PH neutralization system (individual tenant system) permitting, use and operation
	  				  	 	X	  
	 Lab waste and vent pipe distribution
	  				  	 	X	  
	 Hot water generation for core restrooms
	  	 	X	  	  			
	 Non-potable Hot water generation for Tenant use, prorata share of existing available capacity
	  	 	X	  	  			
	 Existing central lab air compressor and piping risers
	  	 	X	  	  			
	 Compressed air pipe distribution in Tenant Premises for specific points of use
	  				  	 	X	  
	 Central lab vacuum system and pipe risers
	  	 	X	  	  			
	 Lab vacuum pipe distribution in Tenant Premises for specific points of use
	  				  	 	X	  
	 The existing tepid water generator and pipe risers will be maintained and operated by the tenant
	  				  	 	X	  
	 Tepid water pipe distribution in Tenant Premises
	  				  	 	X	  
	 RO/DI water generator and pipe risers LL shall work with Tenant to coordinate available shaft space for new RODI risers if required.
Tenant shall have access to and sole use of the existing RODI risers if they choose to install their own system. If the tenant chooses to use the existing risers their work will include isolating and capping of the RODI distribution branch lines on
the 5th floor at each riser
	  				  	 	X	  
	 RO/DI water pipe distribution in Tenant Premises for specific points of use
	  				  	 	X	  
	 Manifolds, piping, and other requirements including cylinders, not specifically mentioned above
	  				  	 	X	  

  
 - 17 - 

					
	 NATURAL GAS
	  		  	
	 Natural gas service to Building and piping to Base Building boilers and Base Building generator
	  	X	  	
	 Natural gas service, pressure regulator and meter for Tenant equipment
	  		  	X
	 Natural gas piping from Tenant meter to Tenant Premises or Tenant equipment area.
	  		  	X
	 Natural gas pipe distribution within Tenant Premises
	  		  	X
	 Natural gas pressure regulator vent pipe riser from valve location through roof
	  		  	X
	 HEATING, VENTILATION, AIR CONDITIONING
	  		  	
	 Building Management System (BMS) for common core area and Landlord Infrastructure
	  	X	  	
	 BMS (compatible with Landlord’s system) within Tenant Premises and Tenant infrastructure
	  		  	X
	 Once-through supply air handling units with 30% prefilters, 85% final filters, with corresponding heating and cooling. Units are sized
for approximately 1.5 cfm per square foot of lab space. 65%/35% tab/office ratio.
	  	X	  	
	 Boiler capacity for hot water reheats at tab/office space
	  	X	  	
	 Hot water reheat distribution to reheat coils
	  		  	X
	 Vertical existing supply air duct distribution
	  	X	  	
	 Tenant Space Supply air duct distribution, VAV terminals, equipment connections, insulation, air terminals, dampers, hangers,
	  		  	X
	 Roof mounted laboratory exhaust fans — Prorata share of Existing Fan
	  	X	  	
	 Existing vertical exhaust air duct risers for general lab exhaust
	  	X	  	
	 Roof mounted laboratory exhaust fans for specialty exhaust systems.
	  		  	X
	 Vertical exhaust air duct risers for dedicated fume hood or specialty exhaust systems LL shall provide tenant with a prorata share of
the available shaft and riser space
	  		  	X
	 Exhaust air duct distribution, exhaust air valves, equipment connections, insulation, air terminals, dampers, hangers, etc. within
Tenant Premises.
	  		  	X
	 Exhaust air duct distribution, exhaust air valves, equipment connections, insulation, air terminals, dampers, hangers, etc.
	  		  	X
	 General Exhaust for Tenant Spaces from Risers
	  		  	X
	 Restroom exhaust for core area restrooms
	  	X	  	
	 Restroom exhaust for restrooms within Tenant Premises The Tenant can re-use the existing dedicated restroom / locker room exhaust fan
REF 2 and the associated duct work to serve their planned locker room located within their space on the 1st floor
	  		  	X
	 Electric room ventilation system for Base Building electrical closets
	  	X	  	
	 Electric room ventilation system for electrical closets within Tenant premises
	  		  	X
	 Sound attenuation for Tenant equipment to comply with Cambridge Noise Ordinance
	  		  	X
	 Additional/ dedicated cooling for Tenant requirements.
	  		  	X

  
 - 18 - 

									
	 ELECTRICAL
	  				  			
	 Electrical utility service to switchgear in main electrical vault
	  	 	X	  	  			
	 Provide the tenant with a proportionate share of the available power based on a sqft allocation
	  	 	X	  	  			
	 560 Amps @ 480 / 277 Volt Stand by Power for floors 1st, 2nd, 3rd, & 4th
	  	 	X	  	  			
	 Standby power distribution within Tenant Premises
	  				  	 	X	  
	 Lighting and power distribution for core areas
	  	 	X	  	  			
	 Lighting and power distribution for Tenant Premises
	  				  	 	X	  
	 Tenant Check Meter (s) for Tenant Connected Loads
	  				  	 	X	  
	 Common area life safety emergency lighting/signage
	  	 	X	  	  			
	 Tenant Premises life safety emergency lighting/signage
	  				  	 	X	  
	 Tenant panels, transformers, etc. in addition to Base Building
	  				  	 	X	  
	 Tenant UPS system, battery backup, and associated equipment/distribution
	  				  	 	X	  
	 FIRE ALARM
	  				  			
	 Base Building fire alarm system with devices in core areas
	  	 	X	  	  			
	 Fire alarm sub panels and devices for Tenant Premises with integration into Base Building system
	  				  	 	X	  
	 Alteration to fire alarm system to facilitate Tenant program
	  				  	 	X	  
	 TELEPHONE/DATA
	  				  			
	 Underground local exchange carrier service to primary demarcation room in basement
	  	 	X	  	  			
	 Tel Data Riser Conduit from demark to each floor
	  	 	X	  	  			
	 Tenant tel/data rooms
	  				  	 	X	  
	 Pathways from demarcation room directly into Tenant tel/data rooms
	  				  	 	X	  
	 Tel/Data cabling from demarcation room Tenant tel/data room.
	  				  	 	X	  
	 Fiber optic service for Tenant use
	  				  	 	X	  
	 Tel/data infrastructure including but not limited to servers, computers, phone systems, switches, routers, MUX panels, equipment racks,
ladder racks, etc.
	  				  	 	X	  
	 Provisioning of circuits and service from service providers
	  				  	 	X	  
	 Audio visual systems and support
	  				  	 	X	  
	 Station cabling from Tenant tel/data room to all Tenant locations, within the suite and exterior to the suite, if needed
	  				  	 	X	  
	 SECURITY
	  				  			
	 Card access at Building entries
	  	 	X	  	  			
	 Card access into or within Tenant Premises on separate Tenant installed and managed system
	  				  	 	X	  

  
 - 19 - 

  
 

 

  
 - 20 -Exhibit 4.11

 

SKYLINE MEDICAL INC.

 

WARRANT AGENCY AGREEMENT 

 

WARRANT AGENCY AGREEMENT (this “Warrant
Agreement”) made as of [·], 2014 (the “Issuance Date”), between Skyline Medical Inc., a Delaware corporation,
with offices at 2915 Commers Drive, Suite 900, Eagan, MN 55121 (the “Company”), and Corporate Stock Transfer,
Inc., a Colorado corporation, with offices at 3200 Cherry Creek Drive South – Suite 430, Denver,
CO 80209 (“Warrant Agent”).

 

WHEREAS, the Company is engaged in a public
offering (the “Offering”) of Common Stock and Warrants and, in connection therewith, has determined to issue
and deliver up to [·] Warrants (the “Warrants”) to the public investors, with each such Warrant evidencing
the right of the holder thereof to purchase one share of the Company’s common stock, par value $0.01 per share (the “Common
Stock”), for $[·], subject to adjustment as described herein; and

 

WHEREAS, the Company has filed with the
U.S. Securities and Exchange Commission (the “Commission”) a Registration Statement, No. 333-198962 on Form
S-1 (as the same may be amended from time to time, the “Registration Statement”) for the registration, under
the Securities Act of 1933, as amended (the “Securities Act”) of, among other securities, the Warrants and the
Common Stock issuable upon exercise of the Warrants (the “Warrant Shares”), and such Registration Statement
was declared effective on [·], 2014; and

 

WHEREAS, the Company desires the Warrant
Agent to act on behalf of the Company, and the Warrant Agent is willing to so act, in connection with the issuance, registration,
transfer, exchange and exercise of the Warrants; and

 

WHEREAS, the Company desires to provide
for the form and provisions of the Warrants, the terms upon which they shall be issued and exercised, and the respective rights,
limitation of rights, and immunities of the Company, the Warrant Agent, and the holders of the Warrants (each, a “Holder”);
and

 

WHEREAS, all acts and things have been done
and performed which are necessary to make the Warrants, when executed on behalf of the Company and countersigned by or on behalf
of the Warrant Agent, as provided herein, the valid and binding obligations of the Company, and to authorize the execution and
delivery of this Warrant Agreement.

 

NOW, THEREFORE, in consideration of the
mutual agreements herein contained, the parties hereto agree as follows:

 

1. Appointment of Warrant Agent.
The Company hereby appoints the Warrant Agent to act as agent for the Company for the Warrants, and the Warrant Agent hereby accepts
such appointment and agrees to perform the same in accordance with the terms and conditions set forth in this Warrant Agreement.

 

    	1

    	 

    

 

2. Warrants.

 

2.1. Form of Warrant. Each Warrant
shall be issued in registered form only, shall be in substantially the form of Exhibit A hereto, the provisions of which
are incorporated herein, and shall be signed by, or bear the facsimile signature of, the Chief Executive Officer, President, Chief
Financial Officer or Treasurer, Secretary or Assistant Secretary of the Company. In the event the person whose facsimile signature
has been placed upon any Warrant shall have ceased to serve in the capacity in which such person signed the Warrant before such
Warrant is issued, it may be issued with the same effect as if he or she had not ceased to be such at the date of issuance. All
of the Warrants shall initially be represented by one or more book-entry certificates (each a “Book-Entry Warrant Certificate”).

 

2.2. Effect of Countersignature.
Unless and until countersigned by the Warrant Agent pursuant to this Warrant Agreement, a Warrant shall be invalid and of no effect
and may not be exercised by a Holder.

 

2.3. Registration.

 

2.3.1. Warrant Register. The Warrant
Agent shall maintain books (“Warrant Register”), for the registration of the original issuance and the registration
of any transfer of the Warrants. Upon the initial issuance of the Warrants, the Warrant Agent shall issue and register the Warrants
in the names of the respective Holders in such denominations and otherwise in accordance with instructions delivered to the Warrant
Agent by the Company. To the extent the Warrants are DTC eligible as of the Issuance Date, all of the Warrants shall be represented
by one or more Book-Entry Warrant Certificates deposited with the Depository Trust Company (the “Depository”)
and registered in the name of Cede & Co., a nominee of the Depository. Ownership of beneficial interests in the Book-Entry
Warrant Certificates shall be shown on, and the transfer of such ownership shall be effected through, records maintained (i) by
the Depository or its nominee for each Book-Entry Warrant Certificate; (ii) by institutions that have accounts with the Depository
(such institution, with respect to a Warrant in its account, a “Participant”); or (iii) directly on the book-entry
records of the Warrant Agent with respect only to owners of beneficial interests that represent such direct registration.

 

If the Warrants are not DTC Eligible as
of the Issuance Date or the Depository subsequently ceases to make its book-entry settlement system available for the Warrants,
the Company may instruct the Warrant Agent to make other arrangements for book-entry settlement within ten (10) Business Days after
the Depository ceases to make its book-entry settlement available. In the event that the Company does not make alternative arrangements
for book-entry settlement within ten (10) Business Days or the Warrants are not eligible for, or it is no longer necessary to have
the Warrants available in, book-entry form, the Warrant Agent shall provide written instructions to the Depository to deliver to
the Warrant Agent for cancellation each Book-Entry Warrant Certificate, and the Company shall instruct the Warrant Agent to deliver
to the Depository definitive Warrant Certificates in physical form evidencing such Warrants. Such definitive Warrant Certificates
shall be in substantially the form annexed hereto as Exhibit A.

 

    	2

    	 

    

 

As used herein, the term “Business
Day” means any day other than Saturday, Sunday or other day on which commercial banks in the City of New York are authorized
or required by law or executive order to remain closed.

 

2.3.2. Beneficial Owner; Registered Holder.
Prior to due presentment for registration of transfer of any Warrant, the Company and the Warrant Agent may deem and treat the
person in whose name such Warrant shall be registered upon the Warrant Register (“registered holder”), as the absolute
owner of such Warrant and of each Warrant represented thereby (notwithstanding any notation of ownership or other writing on the
Warrant Certificate made by anyone other than the Company or the Warrant Agent), for the purpose of any exercise thereof, and for
all other purposes, and neither the Company nor the Warrant Agent shall be affected by any notice to the contrary. Any person in
whose name ownership of a beneficial interest in the Warrants evidenced by a Book-Entry Warrant Certificate is recorded in the
records maintained by the Depository or its nominee shall be deemed the “beneficial owner” thereof; provided,
that all such beneficial interests shall be held through a Participant which shall be the registered holder of such Warrants. As
used herein, the term “Holder” refers only to a registered holder of the Warrants.

 

2.4. Uncertificated Warrants. Notwithstanding
the foregoing and anything else herein to the contrary, the Warrants may be issued in uncertificated form.

 

3. Terms and Exercise of Warrants.

 

3.1. Exercise Price. Each Warrant
shall, when countersigned by the Warrant Agent, entitle the Holder, subject to the provisions of such Warrant and of this Warrant
Agreement, to purchase from the Company the number of shares of Common Stock stated therein, at the price of $[·] per whole
share, subject to the subsequent adjustments provided in Section 4 hereof. The term “Exercise Price” as used in this
Warrant Agreement refers to the price per share at which Common Stock may be purchased at the time a Warrant is exercised.

 

3.2. Duration of Warrants. A Warrant
may be exercised only during the period (“Exercise Period”) commencing on the Issuance Date and terminating
at 5:00 P.M., New York City time on [·], 2019 (“Expiration Date”). Each Warrant not exercised on or before
the Expiration Date shall become void, and all rights thereunder and all rights in respect thereof under this Warrant Agreement
shall cease at the close of business on the Expiration Date.

 

3.3. Exercise of Warrants.

 

3.3.1. Exercise and Payment. A Holder
may exercise a Warrant by delivering, not later than 5:00 P.M., New York City time, on any Business Day during the Exercise Period
(the “Exercise Date”) to the Warrant Agent at its corporate trust department (i) the Warrant Certificate evidencing
the Warrants to be exercised, or, in the case of a Book-Entry Warrant Certificate, the Warrants to be exercised (the “Book-Entry
Warrants”) shown on the records of the Depository to an account of the Warrant Agent at the Depository designated for
such purpose in writing by the Warrant Agent to the Depository from time to time, (ii) an election to purchase the Warrant Shares
underlying the Warrants to be exercised (an “Election to Purchase”), properly completed and executed by the
Holder on the reverse of the Warrant Certificate or, in the case of a Book-Entry Warrant Certificate, properly delivered by the
Participant in accordance with the Depository’s procedures, and (iii) the Exercise Price for each Warrant to be exercised
in lawful money of the United States of America by certified or official bank check or by bank wire transfer in immediately available
funds.

 

    	3

    	 

    

 

If any of (A) the Warrant Certificate or
the Book-Entry Warrants, (B) the Election to Purchase, or (C) the Exercise Price therefor, is received by the Warrant Agent after
5:00 P.M., New York City time, on the specified Exercise Date, the Warrants will be deemed to be received and exercised on the
Business Day next succeeding the Exercise Date. If the date specified as the Exercise Date is not a Business Day, the Warrants
will be deemed to be received and exercised on the next succeeding day that is a Business Day. If the Warrants are received or
deemed to be received after the Expiration Date, the exercise thereof will be null and void and any funds delivered to the Warrant
Agent will be returned to the Holder. In no event will interest accrue on funds deposited with the Warrant Agent in respect of
an exercise or attempted exercise of Warrants. If there is a dispute as to whether a Warrant delivered for exercise on the Expiration
Date is valid, the Warrant Agent shall have the right to rely on the Company’s determination as to whether such exercise
is valid. Neither the Company nor the Warrant Agent shall have any obligation to inform a Holder of the invalidity of any exercise
of any Warrants.

 

The Warrant Agent shall promptly deposit
all funds received by it in payment of the Exercise Price in the account of the Company maintained with the Warrant Agent for such
purpose and shall advise the Company via telephone at the end of each day on which funds for the exercise of the Warrants are received
of the amount so deposited to its account. The Warrant Agent shall promptly confirm such telephonic advice to the Company in writing.

 

3.3.2. Issuance of Certificates.
The Warrant Agent shall, by 11:00 A.M. New York City time on the Business Day following the Exercise Date of any Warrant, advise
the Company or the transfer agent and registrar in respect of (a) the number of Warrant Shares issuable upon such exercise in accordance
with the terms and conditions of this Warrant Agreement, (b) the instructions of each Holder with respect to delivery of the Warrant
Shares issuable upon such exercise, and the delivery of definitive Warrant Certificates, as appropriate, evidencing the balance,
if any, of the Warrants remaining after such exercise, (c) in case of a Book-Entry Warrant Certificate, the notation that shall
be made to the records maintained by the Depository, its nominee for each Book-Entry Warrant Certificate, or a Participant, as
appropriate, evidencing the balance, if any, of the Warrants remaining after such exercise and (d) such other information as the
Company or such transfer agent and registrar shall reasonably require.

 

The Company shall, by 5:00 P.M., New York
City time, on the third Business Day next succeeding the Exercise Date of any Warrant and the clearance of the funds in payment
of the aggregate Exercise Price, execute, issue and deliver to the Warrant Agent, the Warrant Shares to which such Holder is entitled,
in fully registered form, registered in such name or names as may be directed by such Holder. Upon receipt of such Warrant Shares,
the Warrant Agent shall, by 5:00 P.M., New York City time, on the third Business Day next succeeding such Exercise Date, transmit
such Warrant Shares to, or upon the order of, such Holder.

 

    	4

    	 

    

 

In lieu of delivering physical certificates
representing the Warrant Shares issuable upon exercise of any Warrants, provided the Company’s transfer agent is participating
in the Depository’s Fast Automated Securities Transfer program, the Company shall use its commercially reasonable efforts
to cause its transfer agent to electronically transmit the Warrant Shares issuable upon exercise to the Depository by crediting
the account of the Depository or of the Participant, as the case may be, through its Deposit Withdrawal Agent Commission system.
The time periods for delivery described in the immediately preceding paragraph shall apply to the electronic transmittals described
herein.

 

3.3.3. Valid Issuance. All Warrant
Shares issued upon the proper exercise of a Warrant in conformity with this Warrant Agreement shall be validly issued, fully paid
and nonassessable.

 

3.3.4. No Fractional Exercise. Warrants
may be exercised only in whole numbers of Warrant Shares. No fractional Warrant Shares are to be issued upon the exercise of a
Warrant, but rather the number of Warrant Shares to be issued shall be rounded up or down, as applicable, to the nearest whole
number. If fewer than all of the Warrants evidenced by a Warrant Certificate are exercised, a new Warrant Certificate for the number
of unexercised Warrants remaining shall be executed by the Company and countersigned by the Warrant Agent as provided in Section
2 of this Warrant Agreement, and delivered to the Holder at the address specified on the books of the Warrant Agent or as otherwise
specified by such Holder. If fewer than all of the Warrants evidenced by a Book-Entry Warrant Certificate are exercised, a notation
shall be made to the records maintained by the Depository, its nominee for each Book-Entry Warrant Certificate, or a Participant,
as appropriate, evidencing the balance of the Warrants remaining after such exercise.

 

3.3.5. No Transfer Taxes. The Company
shall not be required to pay any stamp or other tax or governmental charge required to be paid in connection with any transfer
involved in the issue of the Warrant Shares upon the exercise of Warrants; and in the event that any such transfer is involved,
the Company shall not be required to issue or deliver any Warrant Shares until such tax or other charge shall have been paid or
it has been established to the Company’s satisfaction that no such tax or other charge is due.

 

3.3.6. Date of Issuance. Each person
in whose name any such certificate for Warrant Shares is issued shall for all purposes be deemed to have become the holder of record
of such shares on the date on which the applicable Warrant was surrendered and payment of the Exercise Price was made, irrespective
of the date of delivery of any such certificate, except that, if the date of such surrender and payment is a date when the stock
transfer books of the Company are closed, such person shall be deemed to have become the holder of record of such shares at the
close of business on the next succeeding date on which the stock transfer books are open.

 

3.3.7. Cashless Exercise Under Certain
Circumstances.

 

(i) The Company shall provide to the Holder
prompt written notice of any time that the Company is unable to issue the Warrant Shares via DTC transfer or otherwise (without
restrictive legend), because (A) the Commission has issued a stop order with respect to the Registration Statement, (B) the Commission
otherwise has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, (C) the
Company has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, or (D) otherwise
(each a “Restrictive Legend Event”). To the extent that a Restrictive Legend Event occurs after the Holder has
exercised a Warrant in accordance with the terms of the Warrants but prior to the delivery of the Warrant Shares, the Company shall,
at the election of the Holder to be given within five (5) Business Days of receipt of notice of the Restrictive Legend Event, either
(A) rescind the previously submitted Election to Purchase and the Company shall return all consideration paid by the Holder for
such shares upon such rescission or (B) treat the attempted exercise as a cashless exercise as described in the next paragraph
and refund the cash portion of the Exercise Price to the Holder.

 

    	5

    	 

    

 

(ii) If a Restrictive Legend Event has occurred
and no exemption from the registration requirements is available, the Warrants shall only be exercisable on a cashless basis. Notwithstanding
anything herein to the contrary, the Company shall not be required to make any cash payments or net cash settlement to the Holder
in lieu of issuance of the Warrant Shares. Upon a “cashless exercise,” the Holder shall be entitled to receive a certificate
(or book entry) for the number of Warrant Shares equal to the quotient obtained by dividing [(A-B) (X)] by (A), where:

 

	 	(A) =	the VWAP on the Business Day immediately preceding the date on which the Holder elects to exercise the Warrant by means of a “cashless exercise,” as set forth in the applicable Election to Purchase;
	 	 	 
	 	(B) =	the Exercise Price of the Warrant, as it may have been adjusted hereunder; and
	 	 	 
	 	(X) =	the number of Warrant Shares that would be issuable upon exercise of the Warrant in accordance with the terms of the Warrant if such exercise were by means of a cash exercise rather than a cashless exercise.

 

Upon receipt of an Election to Purchase
for a cashless exercise, the Warrant Agent will promptly deliver a copy of the Election to Purchase to the Company to confirm the
number of Warrant Shares issuable in connection with the cashless exercise. The Company shall calculate and transmit to the Warrant
Agent, and the Warrant Agent shall have no obligation under this section to calculate, the number of Warrant Shares issuable in
connection with the cashless exercise.

 

“VWAP” means, for any
date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted
on NYSE AMEX, the NASDAQ Capital Market, the NASDAQ Global Market, the NASDAQ Global Select Market or the New York Stock Exchange
(each, a “Trading Market”), the daily volume weighted average price of the Common Stock for such date (or the
nearest preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P.
(based on a trading day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time) on any day that the Trading Market
on which the Common Stock is then listed is open for trading), (b) the volume weighted average price of the Common Stock for such
date (or the nearest preceding date) on the OTC Bulletin Board, (c) if the Common Stock is not then listed or quoted for trading
on the OTC Bulletin Board and if prices for the Common Stock are then reported in the “Pink Sheets” published by OTC
Markets, Inc. (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price
per share of the Common Stock so reported, or (d) in all other cases, the fair market value of a share of Common Stock as determined
by an independent appraiser selected in good faith by the Holders of a majority in interest of the Warrants then outstanding and
reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.

 

    	6

    	 

    

 

3.3.8. Disputes. In the case of a
dispute as to the determination of the Exercise Price or the arithmetic calculation of the Warrant Shares, the Company shall promptly
issue to the applicable Holders the number of Warrant Shares that are not disputed.

 

4. Adjustments.

 

4.1. Adjustment upon Subdivision or Combination
of Common Stock. If the Company at any time after the Issuance Date subdivides (by any stock split, stock dividend, recapitalization,
reorganization, scheme, arrangement or otherwise) its outstanding shares of Common Stock into a greater number of shares, the Exercise
Price in effect immediately prior to such subdivision will be proportionately reduced and the number of Warrant Shares will be
proportionately increased. If the Company at any time after the Issuance Date combines (by any stock split, stock dividend, recapitalization,
reorganization, scheme, arrangement or otherwise) its outstanding shares of Common Stock into a smaller number of shares, the Exercise
Price in effect immediately prior to such combination will be proportionately increased and the number of Warrant Shares will be
proportionately decreased. Any adjustment under this Section 4.1 shall become effective at the close of business on the date the
subdivision or combination becomes effective. The Company shall promptly notify Warrant Agent of any such adjustment and give specific
instructions to Warrant Agent with respect to any adjustments to the Warrant Register.

 

4.2. Adjustment for Other Distributions.
In the event the Company shall fix a record date for the making of a dividend or distribution to all holders of Common Stock of
any evidences of indebtedness or assets or subscription rights or warrants (excluding those referred to in Section 4.1 or other
dividends paid out of retained earnings), then in each such case the Exercise Price shall be adjusted by multiplying the Exercise
Price in effect immediately prior to the record date fixed for determination of stockholders entitled to receive such distribution
by a fraction of which the denominator shall be the VWAP determined as of the record date mentioned above, and of which the numerator
shall be such VWAP on such record date less the then per share fair market value at such record date of the portion of such assets
or evidence of indebtedness so distributed applicable to one outstanding share of the Common Stock as determined by the Board of
Directors in good faith. In either case the adjustments shall be described in a statement provided to each Holder of the portion
of assets or evidences of indebtedness so distributed or such subscription rights applicable to one share of Common Stock. Such
adjustment shall be made whenever any such distribution is made and shall become effective immediately after the record date mentioned
above.

 

    	7

    	 

    

 

4.3. Reclassification, Consolidation,
Purchase, Combination, Sale or Conveyance. If, at any time while the Warrants are outstanding, (i) the Company, directly or
indirectly, in one or more related transactions effects any merger or consolidation of the Company with or into another person,
(ii) the Company, directly or indirectly, effects any sale, lease, license, assignment, transfer, conveyance or other disposition
of all or substantially all of its assets in one or a series of related transactions, (iii) any, direct or indirect, purchase offer,
tender offer or exchange offer (whether by the Company or another person) is completed pursuant to which holders of Common Stock
are permitted to sell, tender or exchange their shares for other securities, cash or property and has been accepted by the holders
of 50% or more of the outstanding Common Stock, (iv) the Company, directly or indirectly, in one or more related transactions effects
any reclassification, reorganization or recapitalization of the Common Stock or any compulsory share exchange pursuant to which
the Common Stock is effectively converted into or exchanged for other securities, cash or property, or (v) the Company, directly
or indirectly, in one or more related transactions consummates a stock or share purchase agreement or other business combination
(including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another person whereby
such other person acquires more than 50% of the outstanding shares of Common Stock (not including any shares of Common Stock held
by the other person or other persons making or party to, or associated or affiliated with the other persons making or party to,
such stock or share purchase agreement or other business combination) (each a “Fundamental Transaction”), then,
upon any subsequent exercise of a Warrant, each Holder shall have the right to receive, for each Warrant Share that would have
been issuable upon such exercise immediately prior to the occurrence of such Fundamental Transaction, the same amount and kind
of securities, cash or property, if any, of the successor or acquiring corporation or of the Company, if it is the surviving corporation,
and any additional consideration (the “Alternate Consideration”) receivable as a result of such Fundamental
Transaction by a holder of the number of shares of Common Stock for which each Warrant is exercisable immediately prior to such
Fundamental Transaction. For purposes of any such exercise, the determination of the Exercise Price shall be appropriately adjusted
to apply to such Alternate Consideration based on the amount of Alternate Consideration issuable in respect of one share of Common
Stock in such Fundamental Transaction, and the Company shall apportion the Exercise Price among the Alternate Consideration in
a reasonable manner reflecting the relative value of any different components of the Alternate Consideration. If holders of Common
Stock are given any choice as to the securities, cash or property to be received in a Fundamental Transaction, then the Holder
shall be given the same choice as to the Alternate Consideration that such Holder receives upon any exercise of each Warrant following
such Fundamental Transaction. The Company shall cause any successor entity in a Fundamental Transaction in which the Company is
not the survivor (the “Successor Entity”) and for which stockholders received any equity securities of the Successor
Entity, to assume in writing all of the obligations of the Company under this Warrant Agreement in accordance with the provisions
of this Section 4.3 pursuant to written agreements and shall, upon the written request of such Holder, deliver to such Holder in
exchange for the applicable Warrants created by this Warrant Agreement a security of the Successor Entity evidenced by a written
instrument substantially similar in form and substance to the Warrants which are exercisable for a corresponding number of shares
of capital stock of such Successor Entity (or its parent entity), if any, plus any Alternate Consideration, receivable as a result
of such Fundamental Transaction by a holder of the number of shares of Common Stock for which the Warrants are exercisable immediately
prior to such Fundamental Transaction, and with an exercise price which applies the Exercise Price hereunder to such shares of
capital stock, if any, plus any Alternate Consideration (but taking into account the relative value of the shares of Common Stock
pursuant to such Fundamental Transaction and the value of such shares of capital stock, such number of shares of capital stock
and such exercise price being for the purpose of protecting the economic value of such Warrant immediately prior to the consummation
of such Fundamental Transaction). Upon the occurrence of any such Fundamental Transaction the Successor Entity shall succeed to,
and be substituted for (so that from and after the date of such Fundamental Transaction, the provisions of this Warrant Agreement
and the Warrants referring to the “Company” shall refer instead to the Successor Entity), and may exercise every right
and power of the Company and shall assume all of the obligations of the Company under this Warrant Agreement and the Warrants with
the same effect as if such Successor Entity had been named as the Company herein and therein.

 

    	8

    	 

    

 

The Company shall instruct the Warrant Agent
to mail, by first class mail, postage prepaid, to each Holder, written notice of the execution of any such amendment, supplement
to this Warrant Agreement and/or the Warrants or other agreement. Any such amendment, supplement or other agreement entered into
by the Successor Entity shall provide for adjustments, which shall be as nearly equivalent as may be practicable to the adjustments
provided for in this Section 4. The Warrant Agent shall be under no responsibility to determine the correctness of any provisions
contained in such amendment, supplement or other agreement relating either to the kind or amount of securities or other property
receivable upon exercise of the Warrants or with respect to the method employed and provided therein for any adjustments and shall
be entitled to rely upon the provisions contained in any such amendment, supplement or other agreement. The provisions of this
Section 4.3 shall similarly apply to successive reclassifications, changes, consolidations, mergers, sales and conveyances of the
kind described above.

 

4.4. Other Events. If any event occurs
of the type contemplated by the provisions of Section 4.1, 4.2 or 4.3 but not expressly provided for by such provisions (including,
without limitation, the granting of stock appreciation rights, phantom stock rights or other rights with equity features to all
holders of Common Stock for no consideration), then the Company’s Board of Directors will in good faith make an adjustment
in the Exercise Price and the number of Warrant Shares so as to protect the rights of each Holder.

 

4.5. Notices of Changes in Warrant.
Upon every adjustment of the Exercise Price or the number of Warrant Shares, the Company shall give written notice thereof to the
Warrant Agent, which notice shall state the Exercise Price resulting from such adjustment and the increase or decrease, if any,
in the number of Warrant Shares purchasable upon the exercise of a Warrant, setting forth in reasonable detail the method of calculation
and the facts upon which such calculation is based. Upon the occurrence of any event specified in Sections 4.1, 4.2 or 4.3, then,
in any such event, the Company shall give written notice to each Holder, at the last address set forth for such Holder in the Warrant
Register, of the record date or the effective date of the event. Failure to give such notice, or any defect therein, shall not
affect the legality or validity of such event.

 

4.6. No Fractional Shares. Notwithstanding
any provision contained in this Warrant Agreement to the contrary, the Company shall not issue fractional shares upon exercise
of Warrants. If, by reason of any adjustment made pursuant to this Section 4, a Holder would be entitled, upon the exercise of
such Warrant, to receive a fractional interest in a share, the Company shall, upon such exercise, round up or down, as applicable,
to the nearest whole number the number of Warrant Shares to be issued to such Holder.

 

    	9

    	 

    

 

4.7. Form of Warrant. The form of
Warrant annexed hereto as Exhibit A need not be changed because of any adjustment pursuant to this Section 4, and Warrants
issued after such adjustment may state the same Exercise Price and the same number of shares as is stated in the Warrants initially
issued pursuant to this Warrant Agreement. However, the Company may at any time in its sole discretion make any change in the form
of Warrant that the Company may deem appropriate and that does not affect the substance thereof, and any Warrant thereafter issued
or countersigned, whether in exchange or substitution for an outstanding Warrant or otherwise, may be in the form as so changed.

 

5. Transfer and Exchange of Warrants.

 

5.1. Registration of Transfer. The
Warrant Agent shall register the transfer, from time to time, of any outstanding Warrant upon the Warrant Register, upon surrender
of such Warrant for transfer, properly endorsed with signatures medallion signature guaranteed and accompanied by appropriate instructions
for transfer. Upon any such transfer, a new Warrant representing an equal aggregate number of Warrants shall be issued and the
old Warrant shall be cancelled by the Warrant Agent. The Warrants so cancelled shall be delivered by the Warrant Agent to the Company
from time to time upon request.

 

5.2. Procedure for Surrender of Warrants.
Warrants may be surrendered to the Warrant Agent, together with a written request for exchange or transfer reasonably acceptable
to Warrant Agent, duly executed by the Holder thereof, or by a duly authorized attorney, and thereupon the Warrant Agent shall
issue in exchange therefor one or more new Warrants as requested by the Holder of the Warrants so surrendered, representing an
equal aggregate number of Warrants; provided, however, that except as otherwise provided herein or in any Book-Entry Warrant Certificate,
each Book-Entry Warrant Certificate may be transferred only in whole and only to the Depository, to another nominee of the Depository,
to a successor depository, or to a nominee of a successor depository; provided further, however, that in the event that a Warrant
surrendered for transfer bears a restrictive legend, the Warrant Agent shall not cancel such Warrant and issue new Warrants in
exchange therefor until the Warrant Agent has received an opinion of counsel for the Company stating that such transfer may be
made and indicating whether the new Warrants must also bear a restrictive legend. Upon any such registration of transfer, the Company
shall execute, and the Warrant Agent shall countersign and deliver, in the name of the designated transferee a new Warrant Certificate
or Warrant Certificates of any authorized denomination evidencing in the aggregate a like number of unexercised Warrants.

 

5.3. Fractional Warrants. The Warrant
Agent shall not be required to effect any registration of transfer or exchange which will result in the issuance of a Warrant Certificate
for a fraction of a Warrant.

 

5.4. Service Charges. A service charge
shall be made for any exchange or registration of transfer of Warrants, as negotiated between Company and Warrant Agent.

 

5.5. Warrant Execution and Countersignature.
The Warrant Agent is hereby authorized to countersign and to deliver, in accordance with the terms of this Warrant Agreement, the
Warrants required to be issued pursuant to the provisions of this Section 5, and the Company, whenever required by the Warrant
Agent, will supply the Warrant Agent with Warrants duly executed on behalf of the Company for such purpose.

 

    	10

    	 

    

 

6. Limitations on Exercise. Except
as provided in the last sentence of this Section 6, neither the Warrant Agent nor the Company shall effect any exercise of any
Warrant, and no Holder shall have the right to exercise any portion of a Warrant, to the extent that after giving effect to the
issuance of shares of Common Stock after exercise as set forth on the applicable Election to Purchase, such Holder (together with
such Holder’s Affiliates (as defined in Rule 405 under the Securities Act), and any other persons acting as a group together
with such Holder or any of such Holder’s Affiliates), would beneficially own in excess of 4.99% of the Company’s Common
Stock. For purposes of the foregoing sentence, the number of shares of Common Stock beneficially owned by a Holder and its Affiliates
shall include the number of shares of Common Stock issuable upon exercise of the Warrant with respect to which such determination
is being made, but shall exclude the number of shares of Common Stock which would be issuable upon exercise of the remaining, nonexercised
portion of any Warrant beneficially owned by such Holder or any of its Affiliates. Except as set forth in the preceding sentence,
for purposes of this Section 6, beneficial ownership shall be calculated in accordance with Section 13(d) of the Securities Exchange
Act of 1934, as amended (the “Exchange Act”) and the rules and regulations promulgated thereunder, it being
acknowledged by each Holder that neither the Warrant Agent nor the Company is representing to such Holder that such calculation
is in compliance with Section 13(d) of the Exchange Act and such Holder is solely responsible for any schedules required to be
filed in accordance therewith. To the extent that the limitation contained in this Section 6 applies, the determination of whether
a Warrant is exercisable (in relation to other securities owned by a Holder together with any Affiliates) and of which portion
of a Warrant is exercisable shall be in the sole discretion of a Holder, and the submission of an Election to Purchase shall be
deemed to be such Holder’s determination of whether such Warrant is exercisable (in relation to other securities owned by
such Holder together with any Affiliates) and of which portion of a Warrant is exercisable, and neither the Warrant Agent nor the
Company shall have any obligation to verify or confirm the accuracy of such determination and neither of them shall have any liability
for any error made by such Holder. In addition, a determination as to any group status as contemplated above shall be determined
in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this
Section 6, in determining the number of outstanding shares of Common Stock, a Holder may rely on the number of outstanding shares
of Common Stock as reflected in (A) the Company’s most recent periodic or annual report filed with the Commission, as the
case may be, (B) a more recent public announcement by the Company or (C) a more recent written notice by the Company or the Company’s
transfer agent setting forth the number of shares of Common Stock outstanding. The provisions of this Section 6 shall be construed
and implemented in a manner otherwise than in strict conformity with the terms of this Section 6 to correct this subsection (or
any portion hereof) which may be defective or inconsistent with the intended beneficial ownership limitation herein contained or
to make changes or supplements necessary or desirable to properly give effect to such limitation. The limitations contained in
this Section 6 shall apply to a successor Holder. Notwithstanding the foregoing, the limitations contained in in this Section 6
shall not apply to any Holder who beneficially owns 5%‎ or more of the outstanding Common Stock, not including any shares of
Common Stock deemed to be beneficially owned through the ownership of the Warrants by Holder and any Affiliates.

 

    	11

    	 

    

 

7. Other Provisions Relating to Rights
of Holders of Warrants.

 

7.1. No Rights as Stockholder. Except
as otherwise specifically provided herein, a Holder, solely in its capacity as an owner of a Warrant, shall not be entitled to
vote or receive dividends or be deemed the holder of share capital of the Company for any purpose, nor shall anything contained
in this Warrant Agreement be construed to confer upon a Holder, solely in its capacity as the owner of a Warrant, any of the rights
of a stockholder of the Company or any right to vote, give or withhold consent to any corporate action (whether any reorganization,
issue of stock, reclassification of stock, consolidation, merger, conveyance or otherwise), receive notice of meetings, receive
dividends or subscription rights, or otherwise, prior to the issuance to the Holder of the Warrant Shares which it is then entitled
to receive upon the due exercise of a Warrant. For the avoidance of doubt, ownership of a Warrant does not entitle the Holder or
any beneficial owner thereof to any of the rights of a stockholder.

 

7.2. Lost, Stolen, Mutilated, or Destroyed
Warrants. If any Warrant is lost, stolen, mutilated, or destroyed, the Company will either (i) authorize the Warrant Agent
to instruct the Holder to file documents with the Warrant Agent’s insurance company as reasonably required to obtain an open
penalty bond necessary for the replacement of the Warrant Certificate or (ii) indemnify the Warrant Agent and provide instructions
to the Warrant Agent to replace such Warrant Certificate. Thereafter, the Warrant Agent shall issue a new Warrant of like
denomination, tenor, and date as the Warrant so lost, stolen, mutilated, or destroyed. Any such new Warrant shall constitute a
substitute contractual obligation of the Company, whether or not the allegedly lost, stolen, mutilated, or destroyed Warrant shall
be at any time enforceable by anyone.

 

7.3. Reservation of Common Stock.
The Company shall request that the Warrant Agent at all times reserve and keep available a number of its authorized but unissued
shares of Common Stock that will be sufficient to permit the exercise in full of all outstanding Warrants issued pursuant to this
Warrant Agreement.

 

8. Concerning the Warrant Agent and Other
Matters.

 

8.1. Concerning the Warrant Agent. The
Warrant Agent:

 

a) shall have no duties or obligations other
than those set forth herein and no duties or obligations shall be inferred or implied;

 

b) may rely on and shall be held harmless
by the Company in acting upon any certificate, statement, instrument, opinion, notice, letter, facsimile transmission, telegram
or other document, or any security delivered to it, and reasonably believed by it to be genuine and to have been made or signed
by the proper party or parties;

 

c) may rely on and shall be held harmless
by the Company in acting upon written or oral instructions or statements from the Company with respect to any matter relating to
its acting as Warrant Agent;

 

d) may consult with counsel satisfactory
to it (including counsel for the Company) and shall be held harmless by the Company in relying on the advice or opinion of such
counsel in respect of any action taken, suffered or omitted by it hereunder in good faith and in accordance with such advice or
opinion of such counsel;

 

    	12

    	 

    

 

e) solely shall make the final determination
as to whether or not a Warrant received by Warrant Agent is duly, completely and correctly executed, and Warrant Agent shall be
held harmless by the Company in respect of any action taken, suffered or omitted by Warrant Agent hereunder in good faith and in
accordance with its determination;

 

f) shall not be obligated to take any legal
or other action hereunder which might, in its judgment, subject or expose it to any expense or liability unless it shall have been
furnished with an indemnity satisfactory to it; and

 

g) shall not be liable or responsible for
any failure of the Company to comply with any of the Company’s obligations relating to the Registration Statement or this
Warrant Agreement, including without limitation obligations under applicable regulation or law.

 

8.2. Payment of Taxes. The Company
will from time to time promptly pay all taxes and charges that may be imposed upon the Company or the Warrant Agent in respect
of the issuance or delivery of Warrant Shares upon the exercise of Warrants, but the Company shall not be obligated to pay any
transfer taxes in respect of the Warrants or such Warrant Shares. The Warrant Agent shall not register any transfer or issue or
deliver any Warrant Certificate(s) or Warrant Shares unless or until the persons requesting the registration or issuance shall
have paid to the Warrant Agent for the account of the Company the amount of such tax, if any, or shall have established to the
reasonable satisfaction of the Company that such tax, if any, has been paid.

 

8.3. Resignation, Consolidation, or Merger
of Warrant Agent.

 

8.3.1. Appointment of Successor Warrant
Agent. The Warrant Agent, or any successor to it hereafter appointed, may resign its duties and be discharged from all further
duties and liabilities hereunder after giving 60 days’ prior written notice to the Company. The Warrant Agent may be removed
by the Company by written notice to the Warrant Agent and the holders of the Warrants. If the Warrant Agent shall resign or be
removed or shall otherwise become incapable of acting as Warrant Agent, the Company shall appoint a successor to the Warrant Agent.
If the Company shall fail to make such appointment within a period of 30 days after it has been notified in writing of such resignation
or incapacity by the Warrant Agent or by the holder of the Warrant (who shall, with such notice, submit his Warrant for inspection
by the Company), then the holder of any Warrant may apply to the courts of the State of Delaware
for the appointment of a successor Warrant Agent at the Company’s cost. Any successor Warrant Agent, whether appointed by
the Company or by such court, shall be a corporation organized and existing under the laws of the State of Delaware, in good standing
and having its principal office in the State of Delaware, and authorized under such laws to exercise
corporate trust powers and subject to supervision or examination by federal or state authority. After appointment, any successor
Warrant Agent shall be vested with all the authority, powers, rights, immunities, duties, and obligations of its predecessor Warrant
Agent with like effect as if originally named as Warrant Agent hereunder, without any further act or deed; but if for any reason
it becomes necessary or appropriate, the predecessor Warrant Agent shall execute and deliver, at the expense of the Company, an
instrument transferring to such successor Warrant Agent all the records, property, authority, powers, and rights of such predecessor
Warrant Agent hereunder; and upon request of any successor Warrant Agent the Company shall make, execute, acknowledge, and deliver
any and all instruments in writing for more fully and effectually vesting in and confirming to such successor Warrant Agent all
such authority, powers, rights, immunities, duties, and obligations. Failure to file or mail any notice provided for in this Section,
however, or any defect therein, shall not affect the validity of the resignation or removal of the Warrant Agent or the appointment
of the successor Warrant Agent, as the case may be.

 

    	13

    	 

    

 

8.3.2. Notice of Successor Warrant Agent.
In the event a successor Warrant Agent shall be appointed, the Company shall give notice thereof to the predecessor Warrant Agent
and the transfer agent for the Common Stock not later than the effective date of any such appointment.

 

8.3.3. Merger or Consolidation of Warrant
Agent. Any corporation into which the Warrant Agent may be merged or with which it may be consolidated or any corporation resulting
from any merger or consolidation to which the Warrant Agent shall be a party shall be the successor Warrant Agent under this Warrant
Agreement without any further act.

 

8.4. Fees and Expenses of Warrant Agent.

 

8.4.1. Remuneration. The Company
agrees to pay the Warrant Agent reasonable remuneration in an amount separately agreed to between Company and Warrant Agent for
its services as Warrant Agent hereunder and will reimburse the Warrant Agent upon demand for all expenditures that the Warrant
Agent may reasonably incur in the execution of its duties hereunder.

 

8.4.2. Further Assurances. The Company
agrees to perform, execute, acknowledge, and deliver or cause to be performed, executed, acknowledged, and delivered all such further
and other acts, instruments, and assurances as may reasonably be required by the Warrant Agent for the carrying out or performing
of the provisions of this Warrant Agreement.

 

8.5. Liability of Warrant Agent.

 

8.5.1. Reliance on Company Statement.
Whenever in the performance of its duties under this Warrant Agreement, the Warrant Agent shall deem it necessary or desirable
that any fact or matter be proved or established by the Company prior to taking or suffering any action hereunder, such fact or
matter (unless other evidence in respect thereof be herein specifically prescribed) may be deemed to be conclusively proved and
established by a statement signed by the President, Chief Executive Officer or Chief Financial Officer of the Company and delivered
to the Warrant Agent. The Warrant Agent may rely upon such statement for any action taken or suffered in good faith by it pursuant
to the provisions of this Warrant Agreement.

 

8.5.2. Indemnity. The Warrant Agent
shall be liable hereunder only for its own gross negligence, willful misconduct or bad faith. The Company agrees to indemnify the
Warrant Agent and save it harmless against any and all liabilities, including judgments, claims, losses, damages, costs and reasonable
counsel fees, for anything done or omitted by the Warrant Agent in the execution of this Warrant Agreement except as a result of
the Warrant Agent’s gross negligence, willful misconduct, or bad faith.

 

    	14

    	 

    

 

8.5.3. Exclusions. The Warrant Agent
shall have no responsibility with respect to the validity of this Warrant Agreement or with respect to the validity or execution
of any Warrant (except its countersignature hereof and thereof); nor shall it be responsible for any breach by the Company of any
covenant or condition contained in this Warrant Agreement or in any Warrant; nor shall it be responsible to make any adjustments
required under the provisions of Section 4 hereof or responsible for the manner, method, or amount of any such adjustment or the
ascertaining of the existence of facts that would require any such adjustment; nor shall it by any act hereunder be deemed to make
any representation or warranty as to the authorization or reservation of any Warrant Shares to be issued pursuant to this Warrant
Agreement or any Warrant or as to whether any Warrant Shares will, when issued, be validly issued and fully paid and nonassessable.

 

8.6. Acceptance of Agency. The Warrant
Agent hereby accepts the agency established by this Warrant Agreement and agrees to perform the same upon the terms and conditions
herein set forth and, among other things, shall account promptly to the Company with respect to Warrants exercised and concurrently
account for, and pay to the Company, all moneys received by the Warrant Agent for the purchase of Warrant Shares through the exercise
of Warrants.

 

9. Miscellaneous Provisions.

 

9.1. Successors. All the covenants
and provisions of this Warrant Agreement by or for the benefit of the Company or the Warrant Agent shall bind and inure to the
benefit of their respective successors and assigns.

 

9.2. Notices. Any notice, statement
or demand authorized by this Warrant Agreement to be given or made by the Warrant Agent or by a Holder to or on the Company shall
be sufficiently given when so delivered if by hand or overnight delivery or if sent by certified mail or private courier service
within five (5) Business Days after deposit of such notice, postage prepaid, addressed (until another address is filed in writing
by the Company with the Warrant Agent), as follows:

 

Skyline Medical Inc.

2915 Commers Drive, Suite 900

Eagan, MN 55121

Attn: Bob Myers, Chief Financial Officer

 

with a copy to:

 

Maslon Edelman Borman & Brand, LLP

90 South 7th Street, Suite 3300

Minneapolis, MN 55402

Attn: Martin Rosenbaum

 

Any notice, statement or demand authorized
by this Warrant Agreement to be given or made by the a Holder or by the Company to or on the Warrant Agent shall be sufficiently
given when so delivered if by hand or overnight delivery or if sent by certified mail or private courier service within five (5)
Business Days after deposit of such notice, postage prepaid, addressed (until another address is filed in writing by the Warrant
Agent with the Company), as follows:

 

    	15

    	 

    

 

Corporate Stock Transfer

3200 Cherry Creek Drive South – Suite 430

Denver, CO 80209

Attn: Operations Department

 

with a copy to:

 

Maslon Edelman Borman & Brand, LLP

90 South 7th Street, Suite 3300

Minneapolis, MN 55402

Attn: Martin Rosenbaum

 

9.3. Applicable Law. The validity,
interpretation, and performance of this Warrant Agreement and of the Warrants shall be governed in all respects by the laws of
the State of Delaware, without giving effect to conflicts of law principles that would result in the application of the substantive
laws of another jurisdiction.

 

9.4. Persons Having Rights under this
Warrant Agreement. Nothing in this Warrant Agreement expressed and nothing that may be implied from any of the provisions hereof
is intended, or shall be construed, to confer upon, or give to, any person or corporation other than the parties hereto and the
Holders of the Warrants and, for purposes of Sections 3.3, 9.3 and 9.8, the Underwriter, any right, remedy, or claim under or by
reason of this Warrant Agreement or of any covenant, condition, stipulation, promise, or agreement hereof. The Underwriters shall
be deemed to be an express third-party beneficiary of this Warrant Agreement with respect to Sections 3.3, 9.3 and 9.8 hereof.
All covenants, conditions, stipulations, promises, and agreements contained in this Warrant Agreement shall be for the sole and
exclusive benefit of the parties hereto (and the Underwriters with respect to the Sections 3.3, 9.3 and 9.8 hereof) and their successors
and assigns and of the Holders.

 

9.5. Examination of this Warrant Agreement.
A copy of this Warrant Agreement shall be available at all reasonable times at the office of the Warrant Agent in Denver, Colorado
for inspection by any Holder. The Warrant Agent may require any such Holder to submit his Warrant for inspection by it.

 

9.6. Counterparts. This Warrant Agreement
may be executed in any number of original or facsimile counterparts and each of such counterparts shall for all purposes be deemed
to be an original, and all such counterparts shall together constitute but one and the same instrument.

 

9.7. Effect of Headings. The Section
headings herein are for convenience only and are not part of this Warrant Agreement and shall not affect the interpretation thereof.

 

    	16

    	 

    

 

9.8. Amendments. This Warrant Agreement
may be amended by the parties hereto without the consent of any Holder for the purpose of curing any ambiguity, or of curing, correcting
or supplementing any defective provision contained herein or adding or changing any other provisions with respect to matters or
questions arising under this Warrant Agreement as the parties may deem necessary or desirable and that the parties deem shall not
adversely affect the interest of the Holders. All other modifications or amendments, including any amendment to increase the Exercise
Price or shorten the Exercise Period, shall require the written consent of the Underwriter and the Holders of a majority of the
then outstanding Warrants.

 

9.9. Severability. This Warrant Agreement
shall be deemed severable, and the invalidity or unenforceability of any term or provision hereof shall not affect the validity
or enforceability of this Warrant Agreement or of any other term or provision hereof. Furthermore, in lieu of any such invalid
or unenforceable term or provision, the parties hereto intend that there shall be added as a part of this Warrant Agreement a provision
as similar in terms to such invalid or unenforceable provision as may be possible and be valid and enforceable.

 

9.10. Force Majeure. In the event
either party is unable to perform its obligations under the terms of this Warrant Agreement because of acts of God, strikes, failure
of carrier or utilities, equipment or transmission failure or damage that is reasonably beyond its control, or any other cause
that is reasonably beyond its control, such party shall not be liable for damages to the other for any damages resulting from such
failure to perform or otherwise from such causes. Performance under this Warrant Agreement shall resume when the affected party
or parties are able to perform substantially that party’s duties.

 

[Signature Page Follows]

 

    	17

    	 

    

 

[Signature Page to Warrant Agency Agreement]

 

IN WITNESS WHEREOF, this Warrant Agency
Agreement has been duly executed by the parties hereto as of the day and year first above written.

 

	 	SKYLINE MEDICAL INC.
	 	 	 
	 	By:	 
	 	Name:
	 	Title:
	 	 
	 	CORPORATE STOCK TRANSFER
	 	 	 
	 	By:	 
	 	Name:
	 	Title:

 

    	18

    	 

    

 

Exhibit A

[FORM OF WARRANT CERTIFICATE]

 

EXERCISABLE ONLY IF COUNTERSIGNED BY THE WARRANT

AGENT AS PROVIDED HEREIN.

 

Warrant Certificate Evidencing Warrants to Purchase

Common Stock, par value of $0.01 per share, as described herein.

 

SKYLINE MEDICAL INC.

 

	No. ___________	CUSIP [·]

 

VOID AFTER 5:00 P.M., NEW YORK CITY TIME, ON _______ __,
2019

 

This certifies that ________________________
or registered assigns is the registered holder (the “Holder”) of _____________________ warrants to purchase
certain securities (each a “Warrant”). Each Warrant entitles the Holder, subject to the provisions contained
herein and in the Warrant Agreement (as defined below), to purchase from Skyline Medical Inc., a Delaware corporation (the “Company”),
one share (collectively, the “Warrant Shares”) of Common Stock, par value $0.01 per share, of the Company (“Common
Stock”), at the Exercise Price set forth below. The price per share at which each Warrant Share may be purchased at the
time each Warrant is exercised (the “Exercise Price”) is $[·] initially, subject to adjustments as set
forth in the Warrant Agreement (as defined below).

 

This Warrant Certificate is issued under
and in accordance with the Warrant Agency Agreement, dated as of [·], 2014 (the “Warrant Agreement”),
between the Company and the Warrant Agent (as defined below), and is subject to the terms and provisions contained in the Warrant
Agreement, to all of which terms and provisions the Holder of this Warrant Certificate and the beneficial owners of the Warrants
represented by this Warrant Certificate consent by acceptance hereof. Copies of the Warrant Agreement are on file and can be inspected
at the below-mentioned office of the Warrant Agent and at the office of the Company at 2915 Commers Drive, Suite 900, Eagan, MN
55121. Capitalized terms used but not defined herein shall have the meaning ascribed to them in the Warrant Agreement.

 

Subject to the terms of the Warrant Agreement,
each Warrant evidenced hereby may be exercised in whole but not in part at any time, as specified herein, on any Business Day (as
defined below) occurring during the period (the “Exercise Period”) commencing on the Issuance Date and terminating
at 5:00 P.M., New York City time, on [·], 2019 (the “Expiration Date”). Each Warrant remaining unexercised
after 5:00 P.M., New York City time, on the Expiration Date shall become void, and all rights of the Holder of this Warrant Certificate
evidencing such Warrant shall cease.

 

    	A-1

    	 

    

 

The Holder of the Warrants represented by
this Warrant Certificate may exercise any Warrant evidenced hereby by delivering, not later than 5:00 P.M., New York City time,
on any Business Day during the Exercise Period (the “Exercise Date”) to Corporate Stock Transfer, Inc. (the
“Warrant Agent”, which term includes any successor warrant agent under the Warrant Agreement described below)
at it offices at 3200 Cherry Creek Drive South – Suite 430, Denver, CO 80209, (i) this Warrant Certificate or, in the case
of a Book-Entry Warrant Certificate (as defined in the Warrant Agreement), the Warrants to be exercised (the “Book-Entry
Warrants”) as shown on the records of The Depository Trust Company (the “Depository”) to an account
of the Warrant Agent at the Depository designated for such purpose in writing by the Warrant Agent to the Depository, (ii) an election
to purchase (“Election to Purchase”), properly executed by the Holder hereof on the reverse of this Warrant
Certificate or properly executed by the institution in whose account the Warrant is recorded on the records of the Depository (the
“Participant”), and substantially in the form included on the reverse of this Warrant Certificate and (iii)
unless cashless exercise is permitted under the Warrant Agreement, the Exercise Price for each Warrant to be exercised in lawful
money of the United States of America by certified or official bank check or by bank wire transfer in immediately available funds,
in each case payable to the order of the Company.

 

As used herein, the term “Business
Day” means any day other than Saturday, Sunday or other day on which commercial banks are authorized or required by law
or executive order to remain closed.

 

Warrants may be exercised only in whole
numbers of Warrants. No fractional Warrant Shares are to be issued upon the exercise of this Warrant, but rather the number of
Warrant Shares to be issued shall be rounded up or down, as applicable, to the nearest whole number. If fewer than all of the Warrants
evidenced by this Warrant Certificate are exercised, a new Warrant Certificate for the number of Warrants remaining unexercised
shall be executed by the Company and countersigned by the Warrant Agent as provided in Section 2 of the Warrant Agreement, and
delivered to the Holder of this Warrant Certificate at the address specified on the books of the Warrant Agent or as otherwise
specified by such Holder.

 

The Company shall provide to the Holder
prompt written notice of any time that the Company is unable to issue the Warrant Shares via DTC transfer or otherwise (without
restrictive legend), because (A) the Commission has issued a stop order with respect to the Registration Statement, (B) the Commission
otherwise has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, (C) the
Company has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, or (D) otherwise
(each a “Restrictive Legend Event”). To the extent that a Restrictive Legend Event occurs after the Holder has
exercised a Warrant in accordance with the terms of the Warrants but prior to the delivery of the Warrant Shares, the Company shall,
at the election of the Holder to be given within five (5) Business Days of receipt of notice of the Restrictive Legend Event, either
(A) rescind the previously submitted Election to Purchase and the Company shall return all consideration paid by the Holder for
such shares upon such rescission or (B) treat the attempted exercise as a cashless exercise as described in the next paragraph
and refund the cash portion of the exercise price to the Holder.

 

    	A-2

    	 

    

 

If a Restrictive Legend Event has occurred
and no exemption from the registration requirements is available, the Warrant shall only be exercisable on a cashless basis. Notwithstanding
anything herein to the contrary, the Company shall not be required to make any cash payments or net cash settlement to the Holder
in lieu of issuance of the Warrant Shares. Upon a “cashless exercise,” the Holder shall be entitled to receive a certificate
(or book entry) for the number of Warrant Shares equal to the quotient obtained by dividing [(A-B) (X)] by (A), where:

 

	 	(A) =	the VWAP on the Business Day immediately preceding the date on which the Holder elects to exercise the Warrant by means of a “cashless exercise,” as set forth in the applicable Election to Purchase;
	 	 	 
	 	(B) =	the Exercise Price of the Warrant, as it may have been adjusted hereunder; and
	 	 	 
	 	(X) =	the number of Warrant Shares that would be issuable upon exercise of the Warrant in accordance with the terms of the Warrant if such exercise were by means of a cash exercise rather than a cashless exercise.

 

Upon receipt of an Election to Purchase
for a cashless exercise, the Warrant Agent will promptly deliver a copy of the Election to Purchase to the Company to confirm the
number of Warrant Shares issuable in connection with the cashless exercise. The Company shall calculate and transmit to the Warrant
Agent, and the Warrant Agent shall have no obligation under this section to calculate, the number of Warrant Shares issuable in
connection with the cashless exercise.

 

“VWAP” means, for any
date, the price determined by the first of the following clauses that applies: (a) if the Common Stock is then listed or quoted
on NYSE AMEX, the Nasdaq Capital Market, the Nasdaq Global Market, the Nasdaq Global Select Market or the New York Stock Exchange
(each, a “Trading Market”), the daily volume weighted average price of the Common Stock for such date (or the
nearest preceding date) on the Trading Market on which the Common Stock is then listed or quoted as reported by Bloomberg L.P.
(based on a trading day from 9:30 a.m. (New York City time) to 4:02 p.m. (New York City time) on any day that the Trading Market
on which the Common Stock is then listed is open for trading), (b) the volume weighted average price of the Common Stock for such
date (or the nearest preceding date) on the OTC Bulletin Board, (c) if the Common Stock is not then listed or quoted for trading
on the OTC Bulletin Board and if prices for the Common Stock are then reported in the “Pink Sheets” published by OTC
Markets, Inc. (or a similar organization or agency succeeding to its functions of reporting prices), the most recent bid price
per share of the Common Stock so reported, or (d) in all other cases, the fair market value of a share of Common Stock as determined
by an independent appraiser selected in good faith by the Holders of a majority in interest of the Warrants then outstanding and
reasonably acceptable to the Company, the fees and expenses of which shall be paid by the Company.

 

The Exercise Price and the number of Warrant
Shares purchasable upon the exercise of each Warrant shall be subject to adjustment as provided pursuant to Section 4 of the Warrant
Agreement.

 

    	A-3

    	 

    

 

Upon due presentment for registration of
transfer or exchange of this Warrant Certificate at the stock transfer division of the Warrant Agent, the Company shall execute,
and the Warrant Agent shall countersign and deliver, as provided in Section 5 of the Warrant Agreement, in the name of the designated
transferee one or more new Warrant Certificates of any authorized denomination evidencing in the aggregate a like number of unexercised
Warrants, subject to the limitations provided in the Warrant Agreement.

 

Neither this Warrant Certificate nor the
Warrants evidenced hereby entitles the Holder to any of the rights of a stockholder of the Company, including, without limitation,
the right to receive dividends, or other distributions, exercise any preemptive rights to vote or to consent or to receive notice
as stockholders in respect of the meetings of stockholders or the election of directors of the Company or any other matter.

 

The Warrant Agreement and this Warrant Certificate
may be amended as provided in the Warrant Agreement including, under certain circumstances described therein, without the consent
of the Holder of this Warrant Certificate or the Warrants evidenced thereby.

 

THIS WARRANT CERTIFICATE AND ALL RIGHTS
HEREUNDER AND UNDER THE WARRANT AGREEMENT SHALL BE GOVERNED BY AND INTERPRETED AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE
STATE OF DELAWARE APPLICABLE TO CONTRACTS FORMED AND TO BE PERFORMED ENTIRELY WITHIN THE STATE OF NEW YORK, WITHOUT REGARD TO THE
CONFLICTS OF LAW PROVISIONS THEREOF TO THE EXTENT SUCH PRINCIPLES OR RULES WOULD REQUIRE OR PERMIT THE APPLICATION OF THE LAWS
OF ANOTHER JURISDICTION.

 

This Warrant Certificate shall not be entitled
to any benefit under the Warrant Agreement or be valid or obligatory for any purpose, and no Warrant evidenced hereby may be exercised,
unless this Warrant Certificate has been countersigned by the manual signature of the Warrant Agent.

 

IN WITNESS WHEREOF, the Company has caused
this instrument to be duly executed.

 

	Dated as of ________ __, 2014	 	 
	 	 	 
	 	SKYLINE MEDICAL INC.
	 	 	 
	 	By:	 
	 	Name:	 
	 	Title:	 

 

	CORPORATE STOCK TRANSFER, as Warrant Agent
	By:	 	 
	Name:	 	 
	Title:	 	 

 

    	A-4

    	 

    

 

[REVERSE]

 

Instructions for Exercise of Warrant

 

To exercise the Warrants evidenced hereby, the Holder must,
by 5:00 P.M., New York City time, on the specified Exercise Date, deliver to the Warrant Agent at its stock transfer division,
a certified or official bank check or a bank wire transfer in immediately available funds, in each case payable to the Company,
in an amount equal to the Exercise Price in full for the Warrants exercised. In addition, the Holder must provide the information
required below and deliver this Warrant Certificate to the Warrant Agent at the address set forth below and the Book-Entry Warrants
to the Warrant Agent in its account with the Depository designated for such purpose. The Warrant Certificate and this Election
to Purchase must be received by the Warrant Agent by 5:00 P.M., New York City time, on the specified Exercise Date.

 

ELECTION TO PURCHASE

TO BE EXECUTED IF WARRANT HOLDER DESIRES

TO EXERCISE THE WARRANTS EVIDENCED HEREBY

 

The undersigned hereby irrevocably elects to exercise, on __________,
____ (the “Exercise Date”), __________ Warrants, evidenced by this Warrant Certificate, to purchase, __________
shares (the “Warrant Shares”) of Common Stock, par value of $0.01 per share (the “Common Stock”)
of Skyline Medical Inc., a Delaware corporation (the “Company”), and represents that on or before the Exercise
Date:

 

		·	such Holder has tendered payment for such Warrant Shares by certified or official bank check payable to the order of the Company
c/o Corporate Stock Transfer, Inc., 3200 Cherry Creek Drive South – Suite 430, Denver, CO 80209, or by bank wire transfer
in immediately available funds payable to the Company at Account No. [·], in each case in the amount of $[·] in accordance
with the terms hereof, or

 

		·	[if permitted] the cancellation of such number of Warrant Shares as is necessary, in accordance with the formula set forth
in subsection 3.3.7 of the Warrant Agreement, to exercise this Warrant with respect to the maximum number of Warrant Shares purchasable
pursuant to the cashless exercise procedure set forth in subsection 3.3.7.

 

The undersigned requests that said number of Warrant Shares
be in fully registered form, registered in such names and delivered, all as specified in accordance with the instructions set forth
below.

 

    	A-5

    	 

    

 

If said number of Warrant Shares is less than all of the Warrant
Shares purchasable hereunder, the undersigned requests that a new Warrant Certificate evidencing the remaining balance of the Warrants
evidenced hereby be issued and delivered to the Holder of the Warrant Certificate unless otherwise specified in the instructions
below.

 

The undersigned hereby represents and warrants
that after giving effect to the exercise of the Warrants contemplated by this Exercise Notice, such holder will not be in violation
of the beneficial ownership limits specified in Section 6 of this Warrant Certificate.

 

Dated: ________ __, ____

	 	Name	 	 
	 	 	(Please Print)	 

/ / / / - / / / - / / / / /

(Insert Social Security or Other Identifying Number of Holder)

	 	Address	 	 
	 	Signature	 	 

 

This Warrant may only be exercised by presentation to the Warrant
Agent at one of the following locations:

 

	 	By hand at:	Corporate Stock Transfer, Inc.
	 	 	3200 Cherry Creek Drive South – Suite 430 
	 	 	Denver, CO 80209
	 	 	 
	 	By mail at:	Corporate Stock Transfer, Inc.
	 	 	3200 Cherry Creek Drive South – Suite 430 
	 	 	Denver, CO 80209

 

The method of delivery of this Warrant Certificate is at the
option and risk of the exercising Holder and the delivery of this Warrant Certificate will be deemed to be made only when actually
received by the Warrant Agent. If delivery is by mail, registered mail with return receipt requested, properly insured, is recommended.
In all cases, sufficient time should be allowed to ensure timely delivery.

 

    	A-6

    	 

    

 

(Instructions as to form and delivery of
Warrant Shares and/or Warrant Certificates)

 

	Name in which Warrant Shares are to be registered if other than in the name of the Holder of this Warrant Certificate:	 	 
	 	 	 
	Address to which Warrant Shares are to be mailed if other than to the address of the Holder of this Warrant Certificate as shown on the books of the Warrant Agent:	 	 
	 	 	(Street Address)
	
         

         
	 	(City and State) (Zip Code)
	 	 	 
	Name in which Warrant Certificate evidencing unexercised Warrants, if any, is to be registered if other than in the name of the Holder of this Warrant Certificate:	 	 
	 	 	 
	Address to which certificate representing unexercised Warrants, if any, is to be mailed if other than to the address of the Holder of this Warrant Certificate as shown on the books of the Warrant Agent:	 	 
	 	 	(Street Address)
	 	 	 
	 	 	(City and State) (Zip Code)
	 	 	 
	 	 	Dated:
	 	 	 
	 	 	Signature

 

Signature must conform in all respects to the name of the
Holder as specified on the face of this Warrant Certificate. If Warrant Shares, or a Warrant Certificate evidencing unexercised
Warrants, are to be issued in a name other than that of the Holder hereof or are to be delivered to an address other than the address
of such Holder as shown on the books of the Warrant Agent, the above signature must be guaranteed by a an Eligible Guarantor Institution
(as that term is defined in Rule 17Ad-15 of the Securities Exchange Act of 1934, as amended).

 

	SIGNATURE GUARANTEE	 
	Name of Firm	 	 	 
	Address	 	 	 
	Area Code and Number	 	 	 
	Authorized Signature	 	 	 
	Name	 	 	 
	Title	 	 	 
	Dated:	 	, 20__	 

 

    	A-7

    	 

    

 

ASSIGNMENT

(FORM OF ASSIGNMENT TO BE EXECUTED IF WARRANT
HOLDER

DESIRES TO TRANSFER WARRANTS EVIDENCED HEREBY)

 

FOR VALUE RECEIVED, ____________ HEREBY SELL(S), ASSIGN(S)
AND TRANSFER(S) UNTO 

	 	 	 
	(Please print name and address

including zip code of assignee)	 	(Please insert social security or

other identifying number of assignee)

the rights represented by the within Warrant Certificate and
does hereby irrevocably constitute and appoint ____________ Attorney to transfer said Warrant Certificate on the books of the Warrant
Agent with full power of substitution in the premises.

 

	 	Dated:
	 	Signature
	 	(Signature must conform in all respects to the name of the Holder as specified on the face of this Warrant Certificate and must bear a signature guarantee by an Eligible Guarantor Institution (as that term is defined in Rule 17Ad-15 of the Securities Exchange Act of 1934, as amended).

 

	SIGNATURE GUARANTEE	 
	Name of Firm	 	 
	Address	 	 
	Area Code and Number	 	 
	Authorized Signature	 	 
	Name	 	 
	Title	 	 
	Dated:	 	, 20__

 

    	A-8

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