Document:

Note and Warrant Purchase Agreement

 Exhibit 4.7 
 NOTE AND WARRANT PURCHASE AGREEMENT 
 This Note and Warrant
Purchase Agreement, dated as of January 6, 2011 (this “Agreement”), is entered into by and among Fluidigm Corporation, a Delaware corporation (the “Company”), and the persons and entities listed on the schedule
of investors attached hereto as Schedule I (each an “Investor” and, collectively, the “Investors”), as such Schedule I may be amended in accordance with Section 6 hereof. 

RECITALS 
 A.        On the terms and subject to the conditions set forth herein, each Investor is willing to purchase from the Company, and the Company is willing to sell to
such Investor, a subordinated secured promissory note in the principal amount set forth opposite such Investor’s name on Schedule I hereto, together with a related warrant to acquire shares of the Company’s capital stock.

 B.        Capitalized terms not otherwise defined herein shall have
the meaning set forth in the form of Note (as defined below) attached hereto as Exhibit A. 
 AGREEMENT

 NOW THEREFORE, in consideration of the foregoing, and the representations, warranties, and conditions set
forth below, the parties hereto, intending to be legally bound, hereby agree as follows: 

1.        The Notes and Warrants. 

(a)        Issuance of Notes. Subject to all of the terms and conditions
hereof, the Company agrees to issue and sell to each of the Investors, and each of the Investors severally agrees to purchase, a subordinated secured promissory note in the form of Exhibit A hereto (each, a “Note” and,
collectively, the “Notes”) in the principal amount set forth opposite the respective Investor’s name on Schedule I hereto. The obligations of the Investors to purchase Notes are several and not joint. The aggregate
principal amount for all Notes issued hereunder shall not exceed $5,000,000. 

(b)        Issuance of Warrants. Concurrently with the issuance of the
Notes to the Investors, the Company will issue and sell to each Investor, and each of the Investors severally agrees to purchase, a warrant in the form attached hereto as Exhibit B (each, a “Warrant” and, collectively,
the “Warrants”) to purchase up to the number of shares of the class and series of preferred stock issued by the Company as set forth in the Warrant. 

(c)        Delivery. The sale and purchase of the Notes and Warrants shall
take place at a closing (the “Closing”) to be held at such place and time as the Company and the Investors may determine (the “Closing Date”). At the Closing, the Company will deliver to each of the Investors the
Note and Warrant to be purchased by such Investor, against receipt by the Company of the corresponding purchase price set forth on Schedule I hereto (the “Purchase Price”). The Company may conduct one or more additional
closings on or prior to January 31, 2011 (each, an “Additional Closing”) to be held at such place and time as the Company and the Investors participating in such Additional Closing may determine (each, an “Additional
Closing Date”). At each Additional Closing, the Company will deliver to each of the Investors participating in such Additional Closing the Note and Warrant to be purchased by such Investor, against receipt by the Company of the
corresponding Purchase Price. If requested by the Investor, signed originals of the Investor’s Note(s) and Warrant(s) shall be delivered to Investor’s custodian to be held in escrow pending Investor’s payment of the Purchase Price.
Each of the Notes and Warrants will be registered in such Investor’s name in the Company’s records. 

 (d)        Use of Proceeds.
The proceeds of the sale and issuance of the Notes shall be used for general corporate and working capital purposes. 
 (e)        Payments. The Company will make all cash payments due under the Notes in immediately available funds by 1:00 p.m. Pacific time on the date
such payment is due at the address for such purpose specified below each Investor’s name on Schedule I hereto, or at such other address, or in such other manner, as an Investor or other registered holder of a Note may from time to
time direct in writing. 
 2.        Representations and
Warranties of the Company. The Company represents and warrants to each Investor that, except as set forth in written disclosure documents provided by the Company to the Investors: 

(a)        Due Incorporation, Qualification, etc. The Company (i) is
a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware; (ii) has all requisite corporate power and authority to own, lease and operate its properties and carry on its business as now
conducted and as proposed to be conducted; and (iii) is duly qualified, licensed to do business and in good standing as a foreign corporation in each jurisdiction where the failure to be so qualified or licensed could reasonably be expected to
have a material adverse effect on the Company. 

(b)        Authority. The execution, delivery and performance by the
Company of this Agreement, the Security Agreement (as defined below) and the Subordination Agreement (as defined below) and to issue each Note and to issue each Warrant (collectively, the “Transaction Documents”) and the
consummation of the transactions contemplated thereby (which for purposes of the Transaction Documents include the grant of a perfected interest in the Collateral (as defined in the Security Agreement)) (i) are within the corporate power of the
Company and (ii) have been duly authorized by all necessary actions on the part of the Company. All corporate action on the part of the Company, its directors and its stockholders necessary for the reservation of the equity securities issuable
upon the conversion of the Notes and the exercise of the Warrants (collectively, the “Conversion Securities”) will be taken prior to the issuance of such Conversion Securities. The Conversion Securities, when issued in compliance
with the provisions of this Agreement, the Notes and the Warrants will be validly issued, fully paid and nonassessable and free of any liens or encumbrances and issued in compliance with all applicable federal and securities laws. 

(c)        Enforceability. Each Transaction Document executed, or to be
executed, by the Company has been, or will be, duly executed and delivered by the Company and constitutes, or will constitute, a legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except
as limited by bankruptcy, insolvency or other laws of general application relating to or affecting the enforcement of creditors’ rights generally and general principles of equity. 

(d)        Non-Contravention. The execution and delivery by the Company of
the Transaction Documents executed by the Company and the performance and consummation of the transactions contemplated thereby do not and will not (i) violate the Company’s certificate of incorporation or bylaws (as amended, the
“Charter Documents”) or any material judgment, order, writ, decree, statute, rule or regulation applicable to the Company; (ii) violate any provision of, or result in the breach or the acceleration of, or entitle any other
Person to accelerate (whether after the giving of notice or lapse of time or both), any material mortgage, indenture, agreement, instrument or contract to which the Company is a party or by which it is bound; or (iii) result in the creation or
imposition of any Lien upon any property, asset or revenue of the Company (other than any Lien arising under the Transaction Documents) or the suspension, revocation, impairment, forfeiture, or nonrenewal of any material permit, license,
authorization or approval applicable to the Company, its business or operations, or any of its assets or properties. The Company has complied with or obtained all waivers reasonably necessary with respect to any preemptive rights, rights of first
refusal or similar rights, including any notice or offering periods provided for as part of any such rights, in connection 

  
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with the transactions contemplated hereunder without any third party obtaining any rights to cause the Company to offer or issue any securities of the Company as a result of the consummation of
the transactions contemplated hereunder. 

(e)        Subsidiaries. Each of the Company’s subsidiaries is duly
organized, validly existing and in good standing under the laws of its jurisdiction of organization and is in good standing under such laws and has the power and authority to own, lease and operate its properties and carry on its business as now
conducted. None of the Company’s subsidiaries owns or leases property or engages in any activity in any jurisdiction that might require its qualification to do business as a foreign corporation in such jurisdiction and where such qualification
has not been obtained and in which the failure to qualify as such would have a material adverse effect on the Company and its subsidiaries, taken as a whole. 
 (f)        Approvals. No consent, approval, order or authorization of, or registration, declaration or filing with, any governmental authority or other
Person (including, without limitation, the shareholders of any Person) is required in connection with the execution and delivery of the Transaction Documents executed by the Company and the performance and consummation of the transactions
contemplated thereby, other than such as have been obtained and remain in full force and effect and other than such qualifications or filings under applicable securities laws as may be required in connection with the transactions contemplated by
this Agreement. 
 (g)        No Violation or Default. The
Company is not in violation of or in default with respect to (i) its Charter Documents or any material judgment, order, writ, decree, statute, rule or regulation applicable to such Person; (ii) any material mortgage, indenture, agreement,
instrument or contract to which such Person is a party or by which it is bound (nor is there any waiver in effect which, if not in effect, would result in such a violation or default) or (iii) to the Company’s knowledge, any applicable
statute, rule, regulation, order or restriction of any domestic or foreign government or any instrumentality or agency thereof in respect of the conduct of its business or the ownership of its properties, which violation of which would have a
material adverse effect on the Company. 
 (h)        Litigation.
No claims, actions (including, without limitation, derivative actions), suits, proceedings or investigations are pending or, to the knowledge of the Company, threatened against the Company at law or in equity in any court or before any other
governmental authority that if adversely determined (i) would (alone or in the aggregate) result in a material liability or (ii) seeks to enjoin, either directly or indirectly, the execution, delivery or performance by the Company of the
Transaction Documents or the transactions contemplated thereby. 

(i)        Title. The Company owns and has good and marketable title in
fee simple absolute to, or a valid leasehold interest in, all real properties and good title to its other assets and properties as reflected in the Financial Statements (as defined below) delivered to the Investors (except those assets and
properties disposed of in the ordinary course of business since the date of the Financial Statements) and all assets and properties acquired by the Company since such date (except those disposed of in the ordinary course of business). Such assets
and properties are subject to no Lien other than any Lien arising or permitted under the Transaction Documents. 

(j)        Intellectual Property. To the Company’s knowledge, the
Company owns or possesses sufficient legal rights to all patents, trademarks, service marks, trade names, copyrights, trade secrets, licenses, information, processes and other intellectual property rights (each individually and collectively
“Intellectual Property”) necessary for its business as now conducted and as proposed to be conducted, the lack of which could reasonably be expected to have a Material Adverse Effect. To the knowledge of the Company, the Company has
taken commercially reasonable actions to (i) perfect the Company’s title in the Intellectual Property it owns or has security or other ownership interest in, including recording with the U.S.

  
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Patent and Trademark Office invention assignments for each of the named inventors on each of the U.S. patents and patent applications owned by the Company; and (ii) maintain in confidence
all trade secrets and confidential information that it owns or uses and out of reasonable business procedure should retain in confidence. The Company has not received any communications alleging that the Company has violated or, by conducting its
business as proposed, would violate any of the Intellectual Property of any other person or entity, except, in either case, for standard end-user, object code, internal-use software license and support/maintenance agreements nor is the Company aware
of any valid basis therefore. 
 (k)        Financial Statements.
The financial statements of the Company as of December 31, 2009 and September 30, 2010 delivered to the Investors (the ‘Financial Statements”) (i) are in accordance with the books and records of the Company;
(ii) have been prepared in conformity with GAAP except, with respect to the unaudited financial statements, for the absence of footnotes and subject to normal year-end adjustments; and (iii) are true, correct and complete and fairly
present the consolidated financial position of the Company as of the dates presented therein and the results of operations, changes in financial positions or cash flows, as the case may be, for the periods presented therein. The Company does not
have any contingent obligations, liability for taxes or other outstanding obligations or liabilities which are material in the aggregate, except as disclosed in the Financial Statements furnished by the Company to the Investors. 

(l)        Equity Securities. As of the date hereof, the authorized
capital stock of the Company consists of 31,074,200 shares of common stock, of which 3,351,113 shares are issued and outstanding, and 19,495,372 shares of preferred stock, 657,132 of which are designated Series A preferred stock of which 657,132 are
outstanding; 1,835,354 of which are designated Series B preferred stock, of which 1,835,354 are issued and outstanding; 4,632,898, of which are designated Series C preferred stock, 4,619,039 of which are issued and outstanding; 3,782,690, of which
are designated Series D preferred stock, 3,771,976 of which are issued and outstanding; 7,802,775 of which are designated Series E preferred stock, 6,829,104 of which are issued and outstanding; 106,122 of which are designated Series D-1
preferred stock, none of which are issued and outstanding; and 678,401 of which are designated Series E-1 preferred stock, 99,864 of which are issued and outstanding. The equity securities (“Equity Securities”) of the Company have
the respective rights, preferences and privileges set forth in the Charter Documents in effect on the date hereof. All of the outstanding Equity Securities of the Company have been duly authorized and are validly issued, fully paid and
nonassessable. There are as of the date of this Agreement no options, warrants or rights to purchase Equity Securities of the Company authorized, issued or outstanding, and the Company is not obligated in any other manner to issue shares of its
Equity Securities. There are no restrictions on the transfer of Equity Securities of the Company, other than those imposed by the Charter Documents as of the date hereof, or relevant state and federal securities laws, and no holder of any Equity
Security of the Company or other Person is entitled to preemptive or similar statutory or contractual rights, either arising pursuant to any agreement or instrument to which the Company is a party or that are otherwise binding upon the Company. The
offer and sale of all Equity Securities of the Company issued before the Closing Date complied with or were exempt from registration or qualification under all applicable federal and state securities laws. No Person has the right to demand or other
rights to cause the Company to file any registration statement under the Securities Act relating to any Equity Securities of the Company presently outstanding or that may be subsequently issued, or any right to participate in any such registration
statement. 
 (m)        Accuracy of Information Furnished. None
of the Transaction Documents and none of the other certificates, statements or information furnished to the Investors by or on behalf of the Company in connection with the Transaction Documents or the transactions contemplated thereby contains or
will contain any untrue statement of a material fact or omits or will omit to state a material fact necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. The Company does not represent or
warrant that it will achieve any financial projections provided to the Investors and represents only that such projections were prepared in good faith. 

  
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 (n)        Operating Company.
The Company is an “operating company” within the meaning of Section 22062(b)(2) of the California Financial Code in that (A) it primarily engages, wholly or substantially, directly or indirectly through a majority owned
subsidiary or subsidiaries, in the production or sale, or the research or development, of a product or service other than the investment of capital, (B) it is not an individual or sole proprietorship, (C) it is not an entity with no
specific business plan or purpose and its business plan is not to engage in a merger or acquisition with an unidentified company or companies or other entity or person, and (D) it intends to use the proceeds from the sale of the Notes and
Warrants extended to it solely for the operation of the Company’s business and uses other than personal, family, or household purposes. The Company’s board of directors, in the exercise of its fiduciary duties, has approved the sale of the
Notes based upon a reasonable belief that the loans represented by the Notes are appropriate for the Company after reasonable inquiry concerning the Company’s financing objectives and financial situation. 

3.        Representations and Warranties of Investors. Each Investor, for that
Investor alone, represents and warrants to the Company upon the acquisition of a Note and Warrant as follows: 

(a)        Binding Obligation. Such Investor has full legal capacity,
power and authority to execute and deliver this Agreement and to perform its obligations hereunder. This Agreement and the Transaction Documents constitute valid and binding obligations of such Investor, enforceable in accordance with their terms,
except as limited by bankruptcy, insolvency or other laws of general application relating to or affecting the enforcement of creditors’ rights generally and general principles of equity. 

(b)        Securities Law Compliance. Such Investor has been advised that
the Notes, the Warrants and the underlying securities have not been registered under the Securities Act, or any state securities laws and, therefore, cannot be resold unless they are registered under the Securities Act and applicable state
securities laws or unless an exemption from such registration requirements is available. Such Investor is aware that, except as set forth in the Ninth Amended and Restated Investor Rights Agreement, dated as of November 16, 2009, as amended, by
and among the Company and the parties identified therein, as such agreement may be amended from time to time, the Company is under no obligation to effect any such registration with respect to the Notes, the Warrants or the underlying securities or
to file for or comply with any exemption from registration. Such Investor has not been formed solely for the purpose of making this investment and is purchasing the Notes or Warrants to be acquired by such Investor hereunder for its own account for
investment, not as a nominee or agent, and not with a view to, or for resale in connection with, the distribution thereof, and Investor has no present intention of selling, granting any participation in, or otherwise distributing the same. Such
Investor has such knowledge and experience in financial and business matters that such Investor is capable of evaluating the merits and risks of such investment, is able to incur a complete loss of such investment without impairing such
Investor’s financial condition and is able to bear the economic risk of such investment for an indefinite period of time. Such Investor is an accredited investor as such term is defined in Rule 501 of Regulation D under the Securities
Act and shall submit to the Company such further assurances of such status as may be reasonably requested by the Company. The residency of the Investor (or, in the case of a partnership or corporation, such entity’s principal place of business)
is correctly set forth beneath such Investor’s name on Schedule I hereto. 

(c)        Access to Information. Such Investor acknowledges that the
Company has given such Investor access to the corporate records and accounts of the Company and to all information in its possession relating to the Company, has made its officers and representatives available for interview by such Investor, and has
furnished such Investor with all documents and other information required for such Investor to make an informed decision with respect to the purchase of the Notes and the Warrants. 

(d)        Tax Matters. Such Investor has reviewed with its own tax
advisors the U.S. federal, state and local and non-U.S. tax consequences of this investment and the transactions contemplated by this Agreement. With respect to such matters, such Investor relies solely on any such advisors and not on any

  
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statements or representations of the Company or any of its agents, written or oral. Such Investor understands that it (and not the Company) shall be responsible for its own tax liability that may
arise as a result of this investment and the transactions contemplated by this Agreement. Such Investor understands that Investor may be subject to taxation on any interest and original issue discount paid or accrued under the Note and that the fair
value of the Warrant received by Investor may reduce the purchase price of the Note for U.S. Federal income tax purposes. Such Investor understands that the fair value of the Warrant could equal the total dollar value of the shares issuable under
the Warrant and that the Company makes no representations regarding the fair value of the Warrant or the tax consequences of investing in the Note and the Warrant. 

4.        Conditions to Closing of the Investors. Each
Investor’s obligations at the Closing are subject to the fulfillment, on or prior to the Closing Date, of all of the following conditions, any of which may be waived in whole or in part by all of the Investors: 

(a)        Representations and Warranties. The representations and
warranties made by the Company in Section 2 hereof shall have been true and correct when made, and shall be true and correct on the Closing Date. 
 (b)        Performance. The Company will have performed and complied with all covenants, agreements, obligations, and conditions contained in this Agreement
that are required to be performed or complied with by it on or before the Closing Date. 

(c)        Governmental Approvals and Filings. Except for any notices
required or permitted to be filed after the Closing Date with certain federal and state securities commissions, the Company shall have obtained all governmental approvals required in connection with the lawful sale and issuance of the Notes and
Warrants. 
 (d)        Legal Requirements. At the Closing, the
sale and issuance by the Company, and the purchase by the Investors, of the Notes and Warrants shall be legally permitted by all laws and regulations to which the Investors or the Company are subject. 

(e)        Proceedings and Documents. All corporate and other proceedings
in connection with the transactions contemplated at the Closing and all documents and instruments incident to such transactions shall be reasonably satisfactory in substance and form to the Investors. 

(f)        Transaction Documents. The Company shall have duly executed and
delivered to the Investors the following documents: 
 (i)        this Agreement;

 (ii)        each Note and Warrant issued hereunder; 

(iii)        the Security Agreement in the form of Exhibit C hereto (the
“Security Agreement”); 
 (iv)        all UCC-1 financing statements
and other documents and instruments which the Investor may reasonably request to perfect its security interest in the collateral described in the Security Agreement; and 
 (v)        the Subordination Agreement in the form of Exhibit D hereto (the “Subordination Agreement”). 

  
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 1.        Lighthouse Waiver.
The Company shall have received an executed waiver from Lighthouse Capital Partners V, L.P. (“Lighthouse”) of certain indebtedness covenants in its Loan and Security Agreement No. 4561 with Lighthouse dated March 29, 2005,
as amended. 
 2.        Bridge Bank Waiver. The Company shall
have received an executed waiver from Bridge Bank, National Association (“Bridge Bank”) of certain indebtedness covenants set forth in that certain revolving credit line agreement entered into with Bridge Bank in December 2010.

 (g)        Minimum Investment Amount. The Company shall have
received an executed copy of this Agreement and investment commitments of at least $2,500,000 for the Closing. 

(h)        Amendment to
Charter.        The Sixth Amended and Restated Certificate of Incorporation of the Company in the form attached as Exhibit D shall have been filed with the Secretary of State of the State of
Delaware and shall be in full force and effect. 

5.        Conditions to Additional Closings of the Investors. The
obligations of any Investor participating in an Additional Closing are subject to the fulfillment, on or prior to the applicable Additional Closing Date, of all of the following conditions, any of which may be waived in whole or in part by all of
the Investors participating in such Additional Closing: 

(a)        Representations and Warranties. The representations and
warranties made by the Company in Section 2 hereof shall be true and correct in all material respects on the applicable Additional Closing Date. 
 (b)        Governmental Approvals and Filings. Except for any notices required or permitted to be filed after the Additional Closing Date with certain
federal and state securities commissions, the Company shall have obtained all governmental approvals required in connection with the lawful sale and issuance of the Notes and Warrants at such Additional Closing. 

(c)        Legal Requirements. At the Additional Closing, the sale and
issuance by the Company, and the purchase by the Investors participating in such Additional Closing, of the Notes and Warrants shall be legally permitted by all laws and regulations to which such Investors or the Company are subject. 

(d)        Transaction Documents. The Company shall have duly executed and
delivered to the Investors participating in such Additional Closing each Note and Warrant to be issued at such Additional Closing and shall have delivered to such Investors fully executed copies, if applicable, of all documents delivered to the
Investors participating in the initial Closing. 

6.        Conditions to Obligations of the Company. The
Company’s obligation to issue and sell the Notes to a particular Investor at the Closing and at each Additional Closing is subject to the fulfillment, on or prior to the Closing Date or the applicable Additional Closing Date, of the following
conditions, any of which may be waived in whole or in part by the Company: 

(a)        Representations and Warranties. The representations and
warranties made by such Investor in Section 3 hereof shall be true and correct when made, and shall be true and correct on the Closing Date and the Applicable Closing Date. 

(b)        Governmental Approvals and Filings. Except for any notices
required or permitted to be filed after the Closing Date or the applicable Additional Closing Date with certain federal and state 

  
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securities commissions, the Company shall have obtained all governmental approvals required in connection with the lawful sale and issuance of the Notes. 

(c)        Subordination Agreement. Such Investor shall have executed and
delivered to the Company the Subordination Agreement. 

(d)        Legal Requirements. At the Closing and at each Additional
Closing, the sale and issuance by the Company, and the purchase by such Investor, of the Notes shall be legally permitted by all laws and regulations to which such Investors or the Company are subject. 

(e)        Purchase Price. Such Investor shall have delivered to the
Company the Purchase Price in respect of the Note and Warrant being purchased by such Investor referenced in Section 1(b) hereof. 
 3.        Lighthouse Waiver. The Company shall have received an executed waiver from Lighthouse of certain indebtedness covenants in its Loan and Security
Agreement No. 4561 with Lighthouse dated March 29, 2005, as amended. 

4.        Bridge Bank Waiver. The Company shall have received an executed
waiver from Bridge Bank of certain indebtedness covenants set forth in that certain revolving credit line agreement entered into with Bridge Bank in December 2010. 

7.        Miscellaneous. 

(a)        Waivers and Amendments. Any provision of this Agreement, the
Warrants and the Notes may be amended, waived or modified only upon the written consent of the Company and a Majority in Interest of Investors; provided, however, that (i) no such amendment, waiver or consent shall reduce the
principal amount of any Note or reduce the rate of interest of any Note, without the affected Investor’s written consent, (ii) no amendment or waiver shall affect adversely an Investor's rights hereunder or thereunder in a discriminatory
manner inconsistent with its adverse effects on rights of other Investors (other than as reflected by the different principal amount of Notes held by each Investor), (iii) any amendment of this Section 6(a) shall require the consent of all
Investors, and (iv) no special consideration or inducement may be given to any Investor in connection with such consent that is not given ratably to all Investors. Subject to the foregoing, any amendment or waiver effected in accordance with
this paragraph shall be binding upon all of the parties hereto. Notwithstanding the foregoing, this Agreement may be amended to add a party as an Investor hereunder in connection with Additional Closings without the consent of any other Investor, by
delivery to the Company of a counterparty signature page to this Agreement and the Security Agreement, together with a supplement to Schedule I. Such amendment shall take effect at the Additional Closing and such party shall thereafter be
deemed an “Investor” for all purposes hereunder and Schedule I hereto shall be updated to reflect the addition of such Investor. 
 (b)        Governing Law. This Agreement and all actions arising out of or in connection with this Agreement shall be governed by and construed in accordance
with the laws of the State of California, without regard to the conflicts of law provisions of the State of California or of any other state. 
 (c)        Survival. The representations, warranties, covenants and agreements made herein shall survive the execution and delivery of this Agreement.

 (d)        Successors and Assigns. Subject to the restrictions
on transfer described in Sections 6(e) and 6(f) below, the rights and obligations of the Company and the Investors shall be binding upon and benefit the successors, assigns, heirs, administrators and transferees of the
parties. 

  
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 (e)        Registration, Transfer
and Replacement of the Notes. The Notes issuable under this Agreement shall be registered notes. The Company will keep, at its principal executive office, books for the registration and registration of transfer of the Notes. Prior to
presentation of any Note for registration of transfer, the Company shall treat the Person in whose name such Note is registered as the owner and holder of such Note for all purposes whatsoever, whether or not such Note shall be overdue, and the
Company shall not be affected by notice to the contrary. Subject to any restrictions on or conditions to transfer set forth in any Note, the holder of any Note, at its option, may in person or by duly authorized attorney surrender the same for
exchange at the Company’s chief executive office, and promptly thereafter and at the Company’s expense, except as provided below, receive in exchange therefor one or more new Note(s), each in the principal amount requested by such holder,
dated the date to which interest shall have been paid on the Note so surrendered or, if no interest shall have yet been so paid, dated the date of the Note so surrendered and registered in the name of such Person or Persons as shall have been
designated in writing by such holder or its attorney for the same principal amount as the then unpaid principal amount of the Note so surrendered. Upon receipt by the Company of evidence reasonably satisfactory to it of the ownership of and the
loss, theft, destruction or mutilation of any Note and (i) in the case of loss, theft or destruction, of indemnity reasonably satisfactory to it; or (ii) in the case of mutilation, upon surrender thereof, the Company, at its expense, will
execute and deliver in lieu thereof a new Note executed in the same manner as the Note being replaced, in the same principal amount as the unpaid principal amount of such Note and dated the date to which interest shall have been paid on such Note
or, if no interest shall have yet been so paid, dated the date of such Note. 

(f)        Assignment by the Company. The rights, interests or obligations
hereunder may not be assigned, by operation of law or otherwise, in whole or in part, by the Company without the prior written consent of a Majority in Interest of Investors. 

(g)        Entire Agreement. This Agreement together with the other
Transaction Documents constitute and contain the entire agreement among the Company and Investors and supersede any and all prior agreements, negotiations, correspondence, understandings and communications among the parties, whether written or oral,
respecting the subject matter hereof. 
 (h)        Notices. All
notices, requests, demands, consents, instructions or other communications required or permitted hereunder shall in writing and faxed, mailed or delivered to each party as follows: (i) if to a Investor, at such Investor’s address or
facsimile number set forth in the Schedule of Investors attached as Schedule I, or at such other address as such Investor shall have furnished the Company in writing, or (ii) if to the Company, at 7000 Shoreline Court, Suite 100,
South San Francisco, CA 94080, Attention: Corporate Secretary, or at such other address or facsimile number as the Company shall have furnished to the Investors in writing. All such notices and communications will be deemed effectively given the
earlier of (A) when received, (B) when delivered personally, (C) one business day after being delivered by facsimile (with receipt of appropriate confirmation), (D) one business day after being deposited with an overnight courier
service of recognized standing or (E) four days after being deposited in the U.S. mail, first class with postage prepaid. 
 (i)        Expenses. The Company shall pay the reasonable attorneys fees and expenses of a single counsel to the Investors in connection with the
preparation, execution and delivery of this Agreement and the other Transaction Documents up to a maximum amount of $35,000. 
 (j)        Separability of Agreements; Severability of this Agreement. The Company’s agreement with each of the Investors is a separate agreement and
the sale of the Notes to each of the Investors is a separate sale. Unless otherwise expressly provided herein, the rights of each Investor hereunder are several rights, not rights jointly held with any of the other Investors. Any invalidity,
illegality or limitation on the enforceability of the Agreement or any part thereof, by any Investor whether arising by reason of the law of the respective Investor’s domicile or otherwise, shall in no way affect or impair the validity,
legality or 

  
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enforceability of this Agreement with respect to other Investors. If any provision of this Agreement shall be judicially determined to be invalid, illegal or unenforceable, the validity, legality
and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

(k)        Counterparts. This Agreement may be executed in one or more
counterparts, each of which will be deemed an original, but all of which together will constitute one and the same agreement. Facsimile copies of signed signature pages will be deemed binding originals. 

(l)        Waiver of Potential Conflicts of Interest. Each of the
Investors and the Company acknowledges that Wilson Sonsini Goodrich & Rosati, Professional Corporation (“WSGR”) may have represented and may currently represent certain of the Investors. In the course of such
representation, WSGR may have come into possession of confidential information relating to such Investors. Each of the Investors and the Company acknowledges that WSGR is representing only the Company in this transaction. Pursuant to Rule 3-310 of
the Rules of Professional Conduct promulgated by the State Bar of California, an attorney must avoid representations in which the attorney has or had a relationship with another party interested in the representation without the informed written
consent of all parties affected. By executing this Agreement, each of the Investors and the Company hereby waives any actual or potential conflict of interest which may arise as a result of WSGR’s representation of such persons and entities,
and WSGR’s possession of such confidential information. Each of the Investors and the Company represents that it has had the opportunity to consult with independent counsel concerning the giving of this waiver. 

*    *    *    *    * 

  
 -10-

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

			
	COMPANY:
	
	 FLUIDIGM CORPORATION,
 a Delaware corporation

		
	 By:
	 	 /s/ Gajus V. Worthington

		 	 Gajus V. Worthington,

		 	 President and Chief Executive Officer

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

											
	 INVESTORS:
	 		 		 	 LEHMAN BROTHERS HEALTHCARE VENTURE
CAPITAL

		 		 		 	 L.P.

					
		 		 		 	 By:
	 	 Lehman Brothers HealthCare Venture Capital

		 		 		 		 	 Associates L.P., 

		 		 		 		 	 its General Partner

					
		 		 		 	 By:
	 	 LB I Group Inc.,

		 		 		 		 	 its General Partner

						
		 		 		 	 By:
	 	 /s/ Ashvin Rao
	 	
						
		 		 		 	 Name:
	 	 Ashvin Rao
	 	
						
		 		 		 	 Title:
	 	 Authorized Signatory
	 	
				
	 INVESTORS:
	 		 		 	 LEHMAN BROTHERS P.A. LLC

						
		 		 		 	 By:
	 	 /s/ Ashvin Rao
	 	
						
		 		 		 	 Name:
	 	 Ashvin Rao
	 	
						
		 		 		 	 Title:
	 	 Authorized Signatory
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

											
	 INVESTORS:
	 		 		 	 LEHMAN BROTHERS PARTNERSHIP
ACCOUNT

		 		 		 	 2000/2001, L.P.

					
		 		 		 	 By:
	 	 LB I Group Inc.,

		 		 		 		 	 its General Partner

		 		 		 	 By:
	 	 /s/ Ashvin Rao
	 	
						
		 		 		 	 Name:
	 	 Ashvin Rao
	 	
						
		 		 		 	 Title:
	 	 Authorized Signatory
	 	
				
	 INVESTORS:
	 		 		 	 LEHMAN BROTHERS OFFSHORE PARTNERSHIP
ACCOUNT

		 		 		 	 2000/2001, L.P.

					
		 		 		 	 By:
	 	 LB I Offshore Partners Group Ltd.,

		 		 		 		 	 its General Partner

						
		 		 		 	 By:
	 	 /s/ Ashvin Rao
	 	
						
		 		 		 	 Name:
	 	 Ashvin Rao
	 	
						
		 		 		 	 Title:
	 	 Authorized Signatory
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 CROSS CREEK CAPITAL EMPLOYEES’
FUND, L.P.

				
		 	 By:
	 	 Cross Creek Capital GP, L.P.,
	 	
		 		 	 its Sole General Partner
	 	
				
		 	 By:
	 	 Cross Creek Capital, LLC,
	 	
		 		 	 its Sole General Partner
	 	
				
		 	 By:
	 	 Wasatch Advisors, Inc.,
	 	
		 		 	 its Sole Member
	 	
				
		 	 By:
	 	 /s/ Daniel Thurber
	 	
				
		 	 Name:
	 	 Daniel Thurber
	 	
				
		 	 Title:
	 	 Vice President
	 	
		
	 INVESTORS:
	 	 CROSS CREEK CAPITAL, L.P.

				
		 	 By:
	 	 Cross Creek Capital GP, L.P.,
	 	
		 		 	 its Sole General Partner
	 	
				
		 	 By:
	 	 Cross Creek Capital, LLC,
	 	
		 		 	 its Sole General Partner
	 	
				
		 	 By:
	 	 Wasatch Advisors, Inc.,
	 	
		 		 	 its Sole Member
	 	
				
		 	 By:
	 	 /s/ Daniel Thurber
	 	
				
		 	 Name:
	 	 Daniel Thurber
	 	
				
		 	 Title:
	 	 Vice President
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 WASATCH FUNDS, INC.

		
		 	 WASATCH SMALL CAP GROWTH
FUND

				
		 	 By:
	 	 Wasatch Advisors, Inc.,
	 	
		 		 	 its Investment Adviser
	 	
				
		 	 By:
	 	 /s/ Daniel Thurber
	 	
				
		 	 Name:
	 	 Daniel Thurber
	 	
				
		 	 Title:
	 	 Vice President
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 SIGHTLINE HEALTHCARE FUND III,
L.P.

				
		 	 By:
	 	 /s/ Joseph Biller
	 	
				
		 	 Name:
	 	 Joseph Biller
	 	
				
		 	 Title:
	 	 Vice President
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 MARKWELL PARTNERS

				
		 	 By:
	 	 /s/ [illegible]
	 	
				
		 	 Name:
	 	 [illegible]
	 	
				
		 	 Title:
	 	 Managing Partner
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 DAVID SCOTT FRAMPTON AND GAJA
ROBERTA
 FRAMPTON, AS TRUSTEES OF
THE FRAMPTON
 FAMILY TRUST DTD
4/25/03

				
		 	 By:
	 	 /s/ David Scott Frampton
	 	
				
		 	 Name:
	 	 David Scott Frampton
	 	
				
		 	 Title:
	 	 Trustee of the Frampton Family Trust
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 LEERINK SWANN HOLDINGS, LLC

				
		 	 By:
	 	 /s/ Tim Gerhold
	 	
				
		 	 Name:
	 	 Tim Gerhold
	 	
				
		 	 Title:
	 	 General Counsel
	 	
		
	 INVESTORS:
	 	 LEERINK SWANN CO-INVESTMENT
FUND, LLC

				
		 	 By:
	 	 /s/ [illegible]
	 	
				
		 	 Name:
	 	 [illegible]
	 	
				
		 	 Title:
	 	 Managing Director
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 J.F. SHEA CO., INC. AS NOMINEE
1999-114

				
		 	 By:
	 	 /s/ John C. Morrissey
	 	
				
		 	 Name:
	 	 John C. Morrissey
	 	
				
		 	 Title:
	 	 Executive Vice President
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 THE CONDON FAMILY
TRUST

				
		 	 By:
	 	 /s/ Thomas J. Condon
	 	
				
		 	 Name:
	 	 Thomas J. Condon
	 	
				
		 	 Title:
	 	 TTE
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ Fredrick Stern
	 	
		 	  FREDRICK STERN
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 BURWEN FAMILY TRUST
U/D/T DATED 9/30/88

				
		 	 By:
	 	 /s/ David M. Burwen
	 	
				
		 	 Name:
	 	 David M. Burwen
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 MICHAEL J. REARDON TRUST
AGREEMENT
 DATED JUNE 5, 1996

				
		 	 By:
	 	 /s/ Michael J. Reardon
	 	
				
		 	 Name:
	 	 Michael J. Reardon
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ William L. Caton III, M.D.
	 	
		 	 WILLIAM L. CATON III, M.D.
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ Patrick Tenney
	 	
		 	 PATRICK TENNEY
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 WILLIAM S. BROWN AND BARBARA G.
BROWN,
 OR THEIR SUCCESSORS, AS
TRUSTEES OF THE
 BROWN FRT DTD
3/10/99

				
		 	 By:
	 	 /s/ William S. Brown
	 	
				
		 	 Name:
	 	 William S. Brown
	 	
				
		 	 By:
	 	 /s/ Barbara G. Brown
	 	
				
		 	 Name:
	 	 Barbara G. Brown
	 	
				
		 	 Title:
	 	 Trustees
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ John M. Harland
	 	
		 	 JOHN M. HARLAND
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ Heath Lukatch
	 	
		 	 HEATH LUKATCH
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 NR07, LLC

				
		 	 By:
	 	 /s/ Sumner Rosenberg
	 	
				
		 	 Name:
	 	 Sumner Rosenberg
	 	
				
		 	 Title:
	 	 President/Manager
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 TTC FUND 1B TRUST

				
		 	 By:
	 	 /s/ Philip Albert
	 	
				
		 	 Name:
	 	 Philip Albert
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 ERIK T. ENGELSON, TRUSTEE OF
THE ERIK T.
 ENGELSON TRUST UTD
DATED MARCH 29, 2000

				
		 	 By:
	 	 /s/ Erik T. Engelson
	 	
				
		 	 Name:
	 	 Erik T. Engelson
	 	
				
		 	 Title:
	 	 Trustee
	 	
		
	 INVESTORS:
	 	 ERIK T. ENGELSON, TRUSTEE OF
THE
 ELISABETH NORTH KUECHLER
ENGELSON
 TRUST UTA DATED JANUARY 17,
2001

				
		 	 By:
	 	 /s/ Erik T. Engelson
	 	
				
		 	 Name:
	 	 Erik T. Engelson
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

									
	 INVESTORS:
	 	 STEPHEN J. WEISS AND URSULA G.
WEISS,
 TRUSTEES OF THE WEISS
FAMILY TRUST 1996
 TRUST

					
		 	 By:
	 	 /s/ Stephen J. Weiss
	 		 	
					
		 	 Name:
	 	 Stephen J. Weiss
	 		 	
					
		 	 Title:
	 	 Trustee
	 		 	
			
	 INVESTORS:
	 	 /s/ Stephen J. Weiss
	 	
		 	 STEPHEN J. WEISS
	 		 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ Paul Machle
	 	
		 	 PAUL MACHLE
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

					
	 INVESTORS:
	 	 /s/ Rhett E. Brown
	 	
		 	 RHETT E. BROWN
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 ROBERT D. MCCULLOCH AND
KATHLEEN M.
 MCCULLOCH, TRUSTEES OR
THEIR
 SUCCESSOR(S) OF THE
ROBERT D. MCCULLOCH
 AND KATHLEEN M.
MCCULLOCH FAMILY
 TRUST DATED
NOVEMBER 19, 1997

				
		 	 By:
	 	 /s/ Robert D. McCulloch
	 	
				
		 	 Name:
	 	 Robert D. McCulloch
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 ROBERT F. KORNEGAY, JR. REVOCABLE
TRUST
 U/D/T DATED MAY 27,
2004,

		 	 ROBERT F. KORNEGAY, JR.,
TRUSTEE

				
		 	 By:
	 	 /s/ Robert F. Kornegay
	 	
				
		 	 Name:
	 	 Robert F. Kornegay
	 	
				
		 	 Title:
	 	  
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 WORTHINGTON FAMILY TRUST UAD 03/06/07

GAJUS WORTHINGTON & JAMI A. WORTHINGTON
TRUSTEES

				
		 	 By:
	 	 /s/ Jami A. Worthington

/s/ Gajus Worthington
	 	
				
		 	 Name:
	 	 Jami Worthington, Gajus Worthington
	 	
				
		 	 Title:
	 	 Trustees
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	PAT AND BETSY COLLINS REVOCABLE TRUST
				
		 	 By:
	 	 /s/Patrick Collins
	 	
				
		 	 Name:
	 	 Patrick Collins
	 	
				
		 	 Title:
	 	 Trustee
	 	

  
 [Signature
page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

									
	 INVESTORS:
	 		 	 VIKRAM AND PRATIMA JOG FAMILY
TRUST U/A DATED 6/23/2009 

					
		 		 	 By:
	 	 /s/ Vikram Jog
	 	
					
		 		 	 Name:
	 	 Vikram Jog
	 	
					
		 		 	 Title:
	 	 Trustee
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 FIDELITY CONTRAFUND:

		 	 FIDELITY ADVISOR NEW INSIGHTS FUND

				
		 	 By:
	 	 /s/ Gary Ryan
	 	
				
		 	 Name:
	 	 Gary Ryan
	 	
				
		 	 Title:
	 	 Assistant Treasurer
	 	
		
	 INVESTORS:
	 	 FIDELITY CONTRAFUND: FIDELITY CONTRAFUND

				
		 	 By:
	 	 /s/ Gary Ryan
	 	
				
		 	 Name:
	 	 Gary Ryan
	 	
				
		 	 Title:
	 	 Assistant Treasurer
	 	
		
	 INVESTORS:
	 	 VARIABLE INSURANCE PRODUCTS FUND
II:
 CONTRAFUND PORTFOLIO

				
		 	 By:
	 	 /s/ Gary Ryan
	 	
				
		 	 Name:
	 	 Gary Ryan
	 	
				
		 	 Title:
	 	 Assistant Treasurer
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 VERSANT AFFILIATES FUND 1-A, L.P.
	 	
		 	 VERSANT AFFILIATES FUND 1-B, L.P.
	 	
		 	 VERSANT SIDE FUND I, L.P.
	 	
		 	 VERSANT VENTURE CAPITAL I, L.P.
	 	
				
		 	 By:
	 	 Versant Ventures I, LLC
	 	
		 		 	 its General Partner
	 	
				
		 	 By:
	 	 /s/ Samuel D. Colella
	 	
				
		 	 Name:
	 	 Samuel D. Colella
	 	
				
		 	 Title:
	 	 Managing Director
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	BRADFORD S. GOODWIN AND CATHY W. GOODWIN
AS TRUSTEES
OF THE GOODWIN FAMILY TRUST
U/A/D 7/30/97
				
		 	 By:
	 	 /s/ Brad Goodwin
	 	
				
		 	 Name:
	 	 Brad Goodwin
	 	
				
		 	 Title:
	 	 Trustee
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 	 WS INVESTMENT COMPANY, LLC (2010A)
	 	
				
		 	 By:
	 	 /s/ Chris F. Fennell
	 	
				
		 	 Name:
	 	 Chris F. Fennell
	 	
				
		 	 Title:
	 	 Vice President
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 The parties have caused this Agreement to be duly executed and delivered by
their proper and duly authorized officers as of the date and year first written above. 
  

							
	 INVESTORS:
	 		 	
				
		 	 By:
	 	 /s/ Michael H. McKay
	 	
				
		 	 Name:
	 	 Michael H. McKay
	 	

 [Signature page to Note and Warrant Purchase Agreement] 

 SCHEDULE I 
 SCHEDULE OF INVESTORS 
 January 6, 2011 

 

													
	 	 	 	 	 
	Investor	 	  	 	Purchase Price	 	 	Promissory Note	 	 	Initial Number of
Warrants
	 	 	 	 	 	 	 	 	 	 	 	 	 
	Cross Creek Capital, L.P.	 	 	 	$	        1,365,777.00	  	 	$	        1,365,777.00	  	 	48,777
	Patrick Tenney	 	 	 	$	1,000,000.00	  	 	$	1,000,000.00	  	 	35,714
	Colella Family Trust	 	 	 	$	400,000.00	  	 	$	400,000.00	  	 	14,285
	Mag & Co fbo Fidelity Contrafund: Fidelity Contrafund	 	 	 	$	376,567.95	  	 	$	376,567.95	  	 	13,448
	Versant Venture Capital I, L.P.	 	 	 	$	368,000.00	  	 	$	368,000.00	  	 	13,142
	Lehman Brothers P.A. LLC	 	 	 	$	148,406.99	  	 	$	148,406.99	  	 	5,300
	Cross Creek Capital Employees’ Fund, L.P.	 	 	 	$	134,223.00	  	 	$	134,223.00	  	 	4,793
	David Scott Frampton and Gaja Roberta Frampton, as Trustees of the Frampton Family Trust Dtd
4/25/03	 	 	 	$	124,975.00	  	 	$	124,975.00	  	 	4,463
	Mag & Co fbo Variable Insurance Products Fund II: Contrafund Portfolio	 	 	 	$	115,781.53	  	 	$	115,781.53	  	 	4,135
	Robert D. McCulloch and Kathleen M. McCulloch, Trustee, or their successor(s)	 	 	 	$	100,000.00	  	 	$	100,000.00	  	 	3,571
	Vikram and Pratima Jog Family Trust u/a dated 6/23/2009	 	 	 	$	100,000.00	  	 	$	100,000.00	  	 	3,571
	Erik T. Engelson, Trustee of the Erik T. Engelson Trust UTD dated March 29, 2000	 	 	 	$	84,000.00	  	 	$	84,000.00	  	 	3,000
	Lehman Brothers Healthcare Venture Capital L.P.	 	 	 	$	77,536.97	  	 	$	77,536.97	  	 	2,769
	Lehman Brothers Partnership Account 2000/2001,
L.P.	 	 	 	$	66,864.11	  	 	$	66,864.11	  	 	2,388

													
	 	 	 	 	 
	Investor	 	  	 	Purchase
Price	 	 	Promissory
Note	 	 	Initial Number of
Warrants
	 	 	 	 	 	 	 	 	 	 	 	 	 
	Mag & Co fbo Fidelity Contrafund: Fidelity Advisor New
Insights Fund	 	 	 	$	41,275.01	  	 	$	41,275.01	  	 	1,474
	SightLine Healthcare Fund III, L.P.	 	 	 	$	25,000.00	  	 	$	25,000.00	  	 	892
	Worthington Family Trust UAD 03/06/07 Gajus Worthington &
Jami A Worthington TTEES	 	 	 	$	25,000.00	  	 	$	25,000.00	  	 	892
	Erik T. Engelson, Trustee of the Elisabeth North Kuechler
Engelson Trust UTA dated January 17, 2001	 	 	 	$	21,000.00	  	 	$	21,000.00	  	 	750
	Stephen J. Weiss and Ursula G. Weiss, Trustees of the Weiss
Family 1996 Trust	 	 	 	$	20,000.00	  	 	$	20,000.00	  	 	714
	Lehman Brothers Offshore Partnership Account 2000/2001,
L.P.	 	 	 	$	17,340.94	  	 	$	17,340.94	  	 	619
	Versant Affiliates Fund 1-B, L.P.	 	 	 	$	16,800.00	  	 	$	16,800.00	  	 	600
	Leerink Swann Co-Investment Fund, LLC	 	 	 	$	16,728.73	  	 	$	16,728.73	  	 	597
	Fredrick Stern	 	 	 	$	15,956.01	  	 	$	15,956.01	  	 	569
	Markwell Partners	 	 	 	$	15,533.14	  	 	$	15,533.14	  	 	554
	Pat and Betsy Collins Revocable Trust	 	 	 	$	10,237.77	  	 	$	10,237.77	  	 	365
	Burwen Family Trust U/D/T Dated 9/30/88	 	 	 	$	10,000.00	  	 	$	10,000.00	  	 	357
	The Condon Family Trust	 	 	 	$	10,000.00	  	 	$	10,000.00	  	 	357
	J.F. Shea Co., Inc. As Nominee 1999-114	 	 	 	$	9,281.82	  	 	$	9,281.82	  	 	331
	Versant Affiliates Fund 1-A, L.P.	 	 	 	$	8,000.00	  	 	$	8,000.00	  	 	285
	Versant Side Fund I, L.P.	 	 	 	$	7,200.00	  	 	$	7,200.00	  	 	257
	WS Investment Company, LLC (2011A)	 	 	 	$	6,764.05	  	 	$	6,764.05	  	 	241
	Leerink Swann Holdings, LLC	 	 	 	$	5,247.44	  	 	$	5,247.44	  	 	187
	John M. Harland	 	 	 	$	5,000.00	  	 	$	5,000.00	  	 	178
	Michael J. Reardon Trust Agreement dated June 5,
1996	 	 	 	$	5,000.00	  	 	$	5,000.00	  	 	178
	Paul Machle	 	 	 	$	5,000.00	  	 	$	5,000.00	  	 	178
	Robert F. Kornegay, Jr. Revocable Trust u/d/t dated May 27,
2004, Robert F. Kornegay, Jr., Trustee	 	 	 	$	5,000.00	  	 	$	5,000.00	  	 	178
	Stephen J. Weiss	 	 	 	$	5,000.00	  	 	$	5,000.00	  	 	178
	William L. Caton III M.D.	 	 	 	$	3,252.77	  	 	$	3,252.77	  	 	116
	Heath Lukatch	 	 	 	$	2,800.00	  	 	$	2,800.00	  	 	100
	William S. Brown and Barbara G. Brown, or their successors, as
Trustees of the Brown FRT DTD 3/10/99	 	 	 	$	2,500.0	  	 	$	2,500.0	  	 	89
	TTC FUND 1B TRUST	 	 	 	$	2,100.0	  	 	$	2,100.0	  	 	75
	NR07, LLC	 	 	 	$	1,661.7	  	 	$	1,661.7	  	 	59
	Bradford S. Goodwin and Cathy W. Goodwin As Trustees of the
Goodwin Family Trust U/A/D 7/30/97	 	 	 	$	1,500.00	  	 	$	1,500.00	  	 	53
	Rhett E. Brown	 	 	 	$	1,071.73	  	 	$	1,071.73	  	 	38
	Michael H. McKay	 	 	 	$	664.43	  	 	$	664.43	  	 	23
	 	 	 	 	 	 	 	 	 	 	 	 	 
	Subtotal:	 	 	 	$	4,784,048.16	  	 	$	4,784,048.16	  	 	170,840

 Exhibit A 
 FORM OF NOTE 

 THIS NOTE AND THE SECURITIES ISSUABLE UPON THE CONVERSION HEREOF HAVE NOT
BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER
THE ACT AND APPLICABLE STATE SECURITIES LAWS PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE OR
TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. 

FOR PURPOSES OF SECTION 1272, 1273 AND 1275 OF THE INTERNAL REVENUE CODE OF 1986, AS AMENDED, THIS NOTE IS BEING ISSUED
WITH AN ORIGINAL ISSUE DISCOUNT. THE COMPANY AGREES TO PROVIDE PROMPTLY TO THE HOLDER OF THIS NOTE, UPON WRITTEN REQUEST, THE ISSUE PRICE, AMOUNT OF ORIGINAL ISSUE DISCOUNT, ISSUE DATE AND YIELD TO MATURITY. ANY SUCH WRITTEN REQUEST SHOULD BE MADE
TO FLUIDIGM CORPORATION, 7000 SHORELINE COURT, SUITE 100, SOUTH SAN FRANCISCO, CA 94080 ATTENTION CHIEF FINANCIAL OFFICER. 

FLUIDIGM CORPORATION 
 SUBORDINATED SECURED PROMISSORY NOTE 
  

			
	 $[                    ]
	  	January 6, 2011

 1. FOR VALUE RECEIVED, Fluidigm Corporation, a Delaware corporation (the “Company”) promises to pay to
[                    ] (“Investor”), or its registered assigns, in lawful money of the United States of America the principal
sum of [                    ]
($[                    ]), or such lesser amount as shall equal the outstanding principal amount hereof, together with interest from the date
of this Subordinated Secured Promissory Note (this “Note”) on the unpaid principal balance. Interest will accrue on the outstanding principal amount of this Note at a rate equal to 8% per annum, computed on the basis of the
actual number of days elapsed and a year consisting of 365 days. All unpaid principal, together with any then unpaid and accrued interest and other amounts payable hereunder, shall be due and payable on the earliest to occur of the following:
(i) (A) the closing of the next Qualified Financing (as defined below in Section 5); (B) the closing of a Change of Control (as defined below in Section 5); and (C) January 6, 2012 (the earlier of (A), (B) or
(C) is referred to as the “Maturity Date”), or (ii) when, upon the occurrence and during the continuance of an Event of Default, such amounts are declared due and payable by a Majority in Interest of Investors or made
automatically due and payable, in each case, in accordance with the terms hereof. This Note is one of the “Notes” issued pursuant to the Purchase Agreement (as defined below in Section 5). 

THE OBLIGATIONS DUE UNDER THIS NOTE ARE (A) SECURED BY A SECURITY AGREEMENT (THE “SECURITY
AGREEMENT”) DATED AS OF JANUARY 6, 2011 AND 

 
EXECUTED BY THE COMPANY FOR THE BENEFIT OF INVESTORS AND (B) SUBJECT TO AND SUBORDINATED BY A SUBORDINATION AGREEMENT (THE “SUBORDINATION AGREEMENT”) DATED AS OF JANUARY 6,
2011 AND EXECUTED BY THE COMPANY AND THE INVESTOR. ADDITIONAL RIGHTS AND OBLIGATIONS OF INVESTOR ARE SET FORTH IN THE SECURITY AGREEMENT AND THE SUBORDINATION AGREEMENT. 

The following is a statement of the rights of Investor and the conditions to which this Note is subject, and to which
Investor, by the acceptance of this Note, agrees: 

1.        Payments. 

  (a)        Interest. Accrued interest on this Note shall be
payable at maturity. 
   (b)        Voluntary
Prepayment. The Company shall not prepay this Note without the written consent of a Majority in Interest of Investors (as defined below in Section 5). 

  (c)        Change of Control Liquidation Preference.
Notwithstanding the introductory paragraph to this Note, if, prior to the repayment of the Note but after the six month anniversary of the issuance date of the Note (the “Issuance Date”), the Company consummates a Change of
Control, then the Investor will be entitled to repayment of an amount equal to 2.5 times the outstanding principal amount of the Note, together with accrued and unpaid interest on the outstanding principal amount to the closing date of the Change of
Control. Notwithstanding the foregoing, in the event the Company has executed a definitive agreement relating to a Change of Control prior to the six month anniversary of the Issuance Date and such Change of Control does not close until after such
six month anniversary due to waiting periods for receipt of regulatory approvals and satisfaction of other customary closing conditions, then the 2.5 times liquidation preference set forth in this Section 1(c) will not apply to such Change of
Control. 
 2.        Events of Default. The occurrence of
any of the following shall constitute an “Event of Default” under this Note and the other Transaction Documents: 
   (a)        Failure to Pay. The Company shall fail to pay (i) when due any principal payment on the due date hereunder or (ii) any
interest payment or other payment required under the terms of this Note or any other Transaction Document on the date due and such payment shall not have been made within five (5) business days of the Company’s receipt of written notice to
the Company of such failure to pay; or 

  (b)        Breaches of Covenants. The Company shall fail to
observe or perform any other covenant, obligation, condition or agreement contained in this Note or the other Transaction Documents (other than those specified in Section 2(a)) and such failure shall continue for ten (10) business
days after the Company’s receipt of written notice to the Company of such failure; or 

  (c)        Representations and Warranties. Any
representation, warranty, certificate, or other statement (financial or otherwise) made or furnished by or on behalf of the Company to Investor in writing in connection with this Note or any of the other Transaction Documents, or as an inducement to
Investor to enter into this Note and the other Transaction Documents, shall be false, incorrect, incomplete or misleading in any material respect when made or furnished; or 

  
 -2-

   (d)        Other
Payment Obligations. Defaults shall exist under any agreements of the Company with any third party or parties which consists of the failure to pay any indebtedness for borrowed money at maturity or which results in a right by such third party or
parties, whether or not exercised, to accelerate the maturity of such indebtedness for borrowed money of the Company, in each case, in an aggregate amount in excess of Five Hundred Thousand Dollars ($500,000); or 

  (e)        Voluntary Bankruptcy or Insolvency Proceedings.
The Company shall (i) apply for or consent to the appointment of a receiver, trustee, liquidator or custodian of itself or of all or a substantial part of its property, (ii) admit in writing its inability to pay its debts generally as
they mature, (iii) make a general assignment for the benefit of its or any of its creditors, (iv) be dissolved or liquidated, (v) commence a voluntary case or other proceeding seeking liquidation, reorganization or other relief with
respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or consent to any such relief or to the appointment of or taking possession of its property by any official in an involuntary case or
other proceeding commenced against it, or (vi) take any action for the purpose of effecting any of the foregoing; or 
   (f)        Involuntary Bankruptcy or Insolvency Proceedings. Proceedings for the appointment of a receiver, trustee, liquidator or custodian of
the Company, or of all or a substantial part of the property thereof, or an involuntary case or other proceedings seeking liquidation, reorganization or other relief with respect to the Company or any of its Subsidiaries, if any, or the debts
thereof under any bankruptcy, insolvency or other similar law now or hereafter in effect shall be commenced and an order for relief entered or such proceeding shall not be dismissed or discharged within 45 days of commencement; or 

  (g)        Judgments. A final judgment or order for the
payment of money in excess of Five Hundred Thousand Dollars ($500,000) (exclusive of amounts covered by insurance) shall be rendered against the Company and the same shall remain undischarged for a period of 30 days during which execution shall not
be effectively stayed, or any judgment, writ, assessment, warrant of attachment, or execution or similar process shall be issued or levied against a substantial part of the property of the Company or any of its Subsidiaries, if any and such
judgment, writ, or similar process shall not be released, stayed, vacated or otherwise dismissed within 30 days after issue or levy. 
 3.        Rights of Investor upon Default. Subject to the terms of the Subordination Agreement, upon the occurrence of any Event of Default (other
than an Event of Default described in Sections 2(e) or 2(f)) and at any time thereafter during the continuance of such Event of Default, Investor may, with the written consent of a Majority in Interest of Investors, by written
notice to the Company, declare all outstanding Obligations payable by the Company hereunder to be immediately due and payable without presentment, demand, protest or any other notice of any kind, all of which are hereby expressly waived, anything
contained herein or in the other Transaction Documents to the contrary notwithstanding. Upon the occurrence of any Event of Default described in Sections 2(e) and 2(f), immediately and without notice, all outstanding Obligations
payable by the Company hereunder shall automatically become immediately due and payable, without presentment, demand, protest or any other notice of any kind, all of which are hereby expressly waived, anything contained herein or in the other
Transaction Documents to the contrary notwithstanding. Subject to the terms of the Subordination Agreement, in addition to the foregoing remedies, upon the occurrence and during the continuance of any Event of Default, Investor may, with the written
consent of a Majority in 

  
 -3-

 
Interest of Investors, exercise any other right, power or remedy granted to it by the Transaction Documents or otherwise permitted to it by law, either by suit in equity or by action at law, or
both. 
 4.        Subordination. The Obligations
evidenced by this Note are hereby expressly subordinated, to the extent and in the manner hereinafter set forth, in right of payment to the prior payment in full of all of the Company’s Senior Indebtedness. 

  (a)        Lien Subordination. Investor subordinates to
holders of Senior Indebtedness any Lien that Investor may have or in the future obtain in any property of the Company. Notwithstanding the respective dates of attachment or perfection of the security interest of Investor and the security interest of
holders of Senior Indebtedness, the security interest of holders of Senior Indebtedness in the property of the Company shall at all times be prior to the security interest of Investor. The subordination and priorities set forth in this paragraph are
expressly conditioned upon the nonavoidability and perfection of the security interest to which another security interest is subordinated, and if the security interest to which another security interest is subordinated is not perfected or is
avoidable, for any reason, then the subordinations and relative priority provided for in this paragraph shall not be effective as to the particular property that is the subject of the unperfected or avoidable security interest. 

  (b)        Payment Subordination. All Obligations are
subordinated in right of payment to all obligations of the Company to holders of Senior Indebtedness now existing or hereafter arising. Investor will not demand or receive from the Company (and the Company will not pay to Investor) all or any part
of the Obligations, by way of payment, prepayment, setoff, lawsuit or otherwise, nor will Investor exercise any remedy with respect to any collateral securing Senior Indebtedness, nor will Investor commence, or cause to commence, prosecute or
participate in any administrative, legal or equitable action against the Company, for so long as any Senior Indebtedness remains outstanding. Notwithstanding the foregoing, the Investor shall be entitled to receive (i) equity securities of the
Company from the conversion of all or any part of the Obligations and payments of cash in lieu of issuing fractional shares in connection with any such conversions, (ii) any note, instrument or other evidence of indebtedness which may be issued
by the Company in exchange for or in substitution of this Note, provided that such note, instrument or other evidence of indebtedness is subordinated to the Senior Indebtedness on the same terms and conditions as set forth in this
Section 4 and (iii) other payments consented to in writing by holders of Senior Indebtedness. 

  (c)        Turnover. Investor shall promptly deliver to
holders of Senior Indebtedness in the form received (except for endorsement or assignment by Investor where required by holders of Senior Indebtedness) for application to the Senior Indebtedness any payment, distribution, security or proceeds
received by Investor with respect to the Obligations other than in accordance with this Section 4. 

  (d)        Insolvency Proceedings. In the event of the
Company’s insolvency, reorganization or any case or proceeding under any bankruptcy or insolvency law or laws relating to the relief of debtors, the provisions of this Section 4 shall remain in full force and effect, and except as
otherwise permitted in this Section 4 the Senior Indebtedness shall be paid in full before any payment is made to Investor. 

  
 -4-

  (e)        Subrogation. Subject to the payment in full of all
Senior Indebtedness, Investor shall be subrogated to the rights of the holder(s) of such Senior Indebtedness (to the extent of the payments or distributions made to the holder(s) of such Senior Indebtedness pursuant to the provisions of this
Section 4) to receive payments and distributions of assets of the Company applicable to the Senior Indebtedness. No such payments or distributions applicable to the Senior Indebtedness shall, as between Company and its creditors, other
than the holders of Senior Indebtedness and Investor, be deemed to be a payment by Company to or on account of this Note; and for purposes of such subrogation, no payments or distributions to the holders of Senior Indebtedness to which Investor
would be entitled except for the provisions of this Section 4 shall, as between Company and its creditors, other than the holders of Senior Indebtedness and Investor, be deemed to be a payment by Company to or on account of the Senior
Indebtedness. 
   (f)        Further Assurances. By
acceptance of this Note, Investor agrees to execute and deliver forms of subordination agreement requested from time to time by holders of Senior Indebtedness, and as a condition to Investor’s rights hereunder, Company may require that Investor
execute such forms of subordination agreement. 

  (g)        Reliance of Holders of Senior Indebtedness.
Investor, by its acceptance hereof, shall be deemed to acknowledge and agree that the foregoing subordination provisions are, and are intended to be, an inducement to and a consideration of each holder of Senior Indebtedness, whether such Senior
Indebtedness was created or acquired before or after the creation of the indebtedness evidenced by this Note, and each such holder of Senior Indebtedness shall be deemed conclusively to have relied on such subordination provisions in acquiring and
holding, or in continuing to hold, such Senior Indebtedness. 

  (h)        Applicability of Priorities. The priority of the
holder of the Senior Indebtedness provided for herein with respect to Liens (but not payment) are applicable only to the extent that such Liens are enforceable and perfected and have not been avoided; if a Lien is judicially determined to be
unenforceable or unperfected or is judicially avoided with respect to any claim of the holder of the Senior Indebtedness or any part thereof, the priority of Lien (but not payment) provided for herein shall not be available to such Lien to the
extent that it is avoided or determined to be unenforceable or unperfected. The foregoing notwithstanding, Investor covenants and agrees that it shall not challenge, attack or seek to avoid any Lien to the extent that it secures any holder of the
Senior Indebtedness. Nothing in this Section 4(h) affects the operation of any subordination of indebtedness or turnover of payment provisions hereof, or of any other agreements among any of the parties hereto. Nothing in this Section 4(h)
impairs or limits Investor’s subordination set forth in Section 4(b). 

  (i)        Other Indebtedness. No indebtedness which does not
constitute Senior Indebtedness shall be senior in any respect to the indebtedness represented by this Note. 

5.        Definitions. As used in this Note, the following
capitalized terms have the following meanings: 
   “Change of Control” shall mean
(i) any reorganization, merger or consolidation of the Company, other than a transaction or series of related transactions in which the holders of the voting securities of the Company outstanding immediately prior to such transaction or series
of 

  
 -5-

 
related transactions retain, immediately after such transaction or series of related transactions, at least 50% of the total voting power represented by the outstanding voting securities of the
Company or such other surviving or resulting entity or (ii) a sale, lease or other disposition of all or substantially all of the assets of the Company. 
   “Event of Default” has the meaning given in Section 2 hereof. 
   “Investor” shall mean the Person specified in the introductory paragraph of this Note or any Person to whom this Note is transferred or assigned pursuant to Section 6(a)
of this Note. 
   “Investors” shall mean the investors that have purchased Notes
pursuant to the Purchase Agreement and any person to whom the Notes are transferred or assigned pursuant to Section 6(a) of each Note. 
   “Lien” shall mean, with respect to any property, any security interest, mortgage, pledge, lien, claim, charge or other encumbrance. 

  “Majority in Interest of Investors” shall mean Investors holding more than 50% of the
aggregate outstanding principal amount of the Notes. 
   “Obligations” shall mean
and include all loans, advances, debts, liabilities and obligations, howsoever arising, owed by the Company to Investor of every kind and description, now existing or hereafter arising under or pursuant to the terms of this Note and the other
Transaction Documents, including, all interest, fees, charges, expenses, attorneys’ fees and costs and accountants’ fees and costs chargeable to and payable by the Company hereunder and thereunder, in each case, whether direct or indirect,
absolute or contingent, due or to become due, and whether or not arising after the commencement of a proceeding under Title 11 of the United States Code (11 U. S. C. Section 101 et seq.), as amended from time to time (including
post-petition interest) and whether or not allowed or allowable as a claim in any such proceeding. Notwithstanding the foregoing, the term “Obligations” shall not include any obligations of Company under or with respect to any warrants to
purchase Company’s capital stock. 
   “Notes” shall mean the subordinated
secured promissory notes issued pursuant to the Purchase Agreement. 
   “Person”
shall mean and include an individual, a partnership, a corporation (including a business trust), a joint stock company, a limited liability company, an unincorporated association, a joint venture or other entity or a governmental authority.

   “Purchase Agreement” shall mean the Note and Warrant Purchase Agreement, dated
as of January 6, 2011 (as amended, modified or supplemented), by and among the Company and the Investors (as defined in the Purchase Agreement) party thereto. 

  “Qualified Financing” is a transaction or series of transactions pursuant to which the
Company issues and sells shares of its capital stock with the principal purpose of raising capital for aggregate gross proceeds of at least $25,000,000. 
   “Securities Act” shall mean the Securities Act of 1933, as amended. 

  
 -6-

   “Security Agreement” has the meaning given in
the introductory paragraphs to this Note. 
   “Senior Indebtedness” shall mean the
principal of (and premium, if any), unpaid interest on and amounts reimbursable, fees, expenses, costs of enforcement and other amounts due in connection with that certain Loan and Security Agreement No. 4561, entered into as of March 29,
2005 by and between Lighthouse Capital Partners V, L.P. and the Company, as amended from time to time, and that certain revolving credit with Bridge Bank, National Association (“Bridge Bank”) entered into with Bridge Bank in
December 2010 (in each case, excluding any amendments after the date of this Note that increases the principal amount available to be borrowed thereunder). 
   “Transaction Documents” shall mean this Note, each of the other Notes, the Purchase Agreement, the Warrants, the Security Agreement, and the Subordination Agreement.

   “Warrant” shall mean the warrant issued to Investor under the Purchase
Agreement. 
 6.        Miscellaneous. 

  (a)        Successors and Assigns; Transfer of this Note or
Securities Issuable on Conversion Hereof. 

      (a)        Subject to the restrictions on transfer described
in this Section 6(a), the rights and obligations of the Company and Investor shall be binding upon and benefit the successors, assigns, heirs, administrators and transferees of the parties. 

      (b)        Each Note transferred and each certificate
representing the securities thus transferred shall bear a legend as to the applicable restrictions on transferability in order to ensure compliance with the Securities Act, unless in the opinion of counsel for the Company such legend is not required
in order to ensure compliance with the Securities Act. The Company may issue stop transfer instructions to its transfer agent in connection with such restrictions. Subject to the foregoing, transfers of this Note shall be registered upon
registration books maintained for such purpose by or on behalf of the Company as provided in the Purchase Agreement. Prior to presentation of this Note for registration of transfer, the Company shall treat the registered holder hereof as the owner
and holder of this Note for the purpose of receiving all payments of principal and interest hereon and for all other purposes whatsoever, whether or not this Note shall be overdue and the Company shall not be affected by notice to the contrary.

       (c)        Neither this Note nor any of the
rights, interests or obligations hereunder may be assigned, by operation of law or otherwise, in whole or in part, by the Company without the prior written consent of a Majority in Interest of Investors. 

  (b)        Waiver and Amendment. Any provision of this Note
may be amended, waived or modified upon the written consent of the Company and a Majority in Interest of Investors; provided, however, that no such amendment, waiver or consent shall: (i) reduce the principal amount of this Note,
(ii) reduce the rate of interest of this Note, or (iii) increase the amount to be paid by any Investor for this Note, without the Investor’s written consent, provided further that, no special consideration or inducement may be
given to any Investor in connection with such consent that is 

  
 -7-

 
not given ratably to all Investors, and that such amendment must apply to all Investors equally and ratably in accordance with the principal amount of Notes held by each Investor. 

  (c)        Notices. All notices, requests, demands, consents,
instructions or other communications required or permitted hereunder shall be in writing and faxed, mailed or delivered to each party at the respective addresses of the parties as set forth in the Purchase Agreement, or at such other address or
facsimile number as the Company shall have furnished to Investor in writing. All such notices and communications will be deemed effectively given the earlier of (i) when received, (ii) when delivered personally, (iii) one business day
after being delivered by facsimile (with receipt of appropriate confirmation), (iv) one business day after being deposited with an overnight courier service of recognized standing or (v) four days after being deposited in the U.S. mail,
first class with postage prepaid. 
   (d)        Pari
Passu Notes. Investor acknowledges and agrees that the payment of all or any portion of the outstanding principal amount of this Note and all interest hereon shall be pari passu in right of payment and in all other respects to the other Notes.
In the event Investor receives payments in excess of its pro rata share of the Company’s payments to the Investors of all of the Notes, then Investor shall hold in trust all such excess payments for the benefit of the holders of the other Notes
and shall pay such amounts held in trust to such other holders upon demand by such holders. 

  (e)        Payment. Unless converted into the Company’s
equity securities pursuant to the terms hereof, payment shall be made in lawful tender of the United States. 

  (f)        Usury. In the event any interest is paid on this
Note which is deemed to be in excess of the then legal maximum rate, then that portion of the interest payment representing an amount in excess of the then legal maximum rate shall be deemed a payment of principal and applied against the principal
of this Note. 
   (g)        Waivers. The Company
hereby waives notice of default, presentment or demand for payment, protest or notice of nonpayment or dishonor and all other notices or demands relative to this instrument. 

  (h)        Governing Law. This Note and all actions arising
out of or in connection with this Note shall be governed by and construed in accordance with the laws of the State of California, without regard to the conflicts of law provisions of the State of California, or of any other state. 

  (i)        Waiver of Jury Trial; Judicial Reference. By
acceptance of this Note, Investor hereby agrees and the Company hereby agrees to waive their respective rights to a jury trial of any claim or cause of action based upon or arising out of this Note or any of the Transaction Documents. If the jury
waiver set forth in this paragraph is not enforceable, then any claim or cause of action arising out of or relating to this Note, the Transaction Documents or any of the transactions contemplated therein shall be settled by judicial reference
pursuant to Code of Civil Procedure Section 638 et seq. before a referee sitting without a jury, such referee to be mutually acceptable to the parties or, if no agreement is reached, by a referee appointed by the Presiding Judge of the
California Superior Court for Santa Clara County. This paragraph shall not restrict a party from 

  
 -8-

 
exercising remedies under the Uniform Commercial Code or from exercising pre-judgment remedies under applicable law. 
 *  *  *  *  * 

  
 -9-

 The Company has caused this Note to be issued as of the date first written
above. 
  

			
	FLUIDIGM CORPORATION,
	 a Delaware corporation

		
	 By:
	 	  

		 	 Gajus V. Worthington,

		 	 President, Chief Executive Officer

 [Signature Page to Subordinated Convertible Promissory Note] 

 Exhibit B 
 FORM OF WARRANT 

 THIS WARRANT AND THE UNDERLYING SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF ANY STATE. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE
SECURITIES LAWS IN ACCORDANCE WITH APPLICABLE REGISTRATION REQUIREMENTS OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE, TRANSFER, PLEDGE OR
HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. THIS WARRANT MUST BE SURRENDERED TO THE COMPANY OR ITS TRANSFER AGENT AS A CONDITION PRECEDENT TO THE SALE, TRANSFER, PLEDGE OR HYPOTHECATION OF ANY INTEREST IN
ANY OF THE SECURITIES REPRESENTED HEREBY. 
 WARRANT TO PURCHASE SHARES OF SERIES E-1 PREFERRED STOCK 

of 

FLUIDIGM CORPORATION 
 Dated as of January 6, 2011 
 Void after the date specified in
Section 8 
  

			
	No. [            ]	  	 Warrant to Purchase
 Shares of Series E-1 Preferred Stock

THIS CERTIFIES THAT, for value received,
[                    ], or its registered assigns (the “Holder”), is entitled, subject to the provisions and upon the
terms and conditions set forth herein, to purchase from Fluidigm Corporation, a Delaware corporation (the “Company”), Shares (as defined below), in the amounts, at such times and at the price per share set forth in
Section 1. The term “Warrant” as used herein shall include this Warrant and any warrants delivered in substitution or exchange therefor as provided herein. This Warrant is issued in connection with the transactions
described in the Note and Warrant Purchase Agreement, dated as of January 6, 2011, by and among the Company and the purchasers described therein (the “Purchase Agreement”). This Warrant is one of a series of warrants
referred to as the “Warrants” in the Purchase Agreement. 
 The following is a statement
of the rights of the Holder and the conditions to which this Warrant is subject, and to which Holder, by acceptance of this Warrant, agrees: 
 1.    Number and Price of Shares; Exercise Period. 
 (a)  Definition of Shares. “Shares” shall mean Series E-1 preferred stock. 

(b)  Number of Shares. Subject to any previous exercise of the Warrant, the Holder shall have the
right to purchase up to the number of Shares that equals the quotient obtained by dividing (x) the Base Coverage (as defined below) by (y) the Base Price (as defined below), prior to (or in connection with) the expiration of this Warrant
as provided in Section 8. 
 (i)  Definition of Base Coverage. “Base
Coverage” shall mean twenty-five percent (25%) of the original principal amount of the Note (as defined below); provided, however, that if the Note remains outstanding on the six month anniversary of the issuance date
of the Note (the “Issuance Date”), Base Coverage shall mean forty-five percent (45%) of the original principal amount of the Note. Notwithstanding the foregoing, if the Company has executed a definitive agreement
relating to a Change of Control prior to the six month anniversary of the Issuance Date and such Change of Control does not close 

 
until after such six month anniversary due to waiting periods for receipt of regulatory approvals and satisfaction of other customary closing conditions, then the additional 20% Base Coverage
that would otherwise apply at the six month anniversary shall not apply, and the applicable Base Coverage shall remain fixed at 25%. 
 (ii)  Definition of Base Price. “Base Price” shall mean $7.00 (as adjusted for stock splits, stock dividends or distributions, recapitalizations and similar
events with respect to the Series E-1 preferred stock). 
 (iii)  Definition of Note.
“Note” shall mean the subordinated secured convertible promissory note issued by the Company to the Holder on the date of this Warrant pursuant to the Purchase Agreement. 

(c)  Exercise Price. The exercise price per Share shall be equal to $0.01, subject to adjustment pursuant hereto
(the “Exercise Price”). 
 (d)  Exercise Period. This Warrant shall be
exercisable, in whole or in part, at any time prior to (or in connection with) the expiration of this Warrant as set forth in Section 8. 
 2.    Exercise of the Warrant. 

(a)  Exercise. The purchase rights represented by this Warrant may be exercised at the election of the Holder,
in whole or in part, in accordance with Section 1, by: 
 (i)  the tender to the Company at its principal office
(or such other office or agency as the Company may designate) of a notice of exercise in the form of Exhibit A (the “Notice of Exercise”), duly completed and executed by or on behalf of the Holder, together with
the surrender of this Warrant; and 
 (ii)  the payment to the Company of an amount equal to (x) the Exercise
Price multiplied by (y) the number of Shares being purchased, by wire transfer or certified, cashier’s or other check acceptable to the Company and payable to the order of the Company. 

(b)  Net Issue Exercise. In lieu of exercising this Warrant pursuant to Section 2(a)(ii), if the fair
market value of one Share is greater than the Exercise Price (at the date of calculation as set forth below), the Holder may elect to receive a number of Shares equal to the value of this Warrant (or of any portion of this Warrant being canceled) by
surrender of this Warrant at the principal office of the Company (or such other office or agency as the Company may designate) together with a properly completed and executed Notice of Exercise reflecting such election, in which event the Company
shall issue to the Holder that number of Shares computed using the following formula: 
  

					
	  
 X =
	 	 Y(A – B)

 
	  	
	 	 	  	
	 	       A
	  	

 Where: 

 

					
	 X
	  	=	  	 The number of Shares to be issued to the Holder

			
	 Y
	  	=	  	 The number of Shares purchasable under this Warrant or, if only a portion of the Warrant is being exercised, the portion of the Warrant being canceled (at the
date of such calculation)

  
 - 2 -

					
	 A
	  	=	  	 The fair market value of one Share (at the date of such calculation)

			
	 B
	  	=	  	 The Exercise Price (as adjusted to the date of such calculation)

For purposes of the calculation above, the fair market value of one Share shall be determined by the Board of Directors
of the Company, acting in good faith, which determination shall include consideration of the illiquidity of such Share; provided, however, that: 
 (i)  if the securities are then traded on a national securities exchange or The NASDAQ Stock Market (or a similar national quotation system) at the time of such exercise, then the fair market
value per Share shall be the product of (x) the average of the closing price of the common stock on such exchange or system over the ten (10) trading day period ending five (5) trading days prior to the date of determination of fair
market value and (y) the number of shares of common stock into which each Share is convertible at the time of such exercise, as applicable; 
 (ii)  if the securities are actively traded over-the-counter at the time of such exercise, then the fair market value per Share shall be the product of (x) the average of the closing bid
prices of the common stock over the ten (10) trading day period ending five (5) trading days prior to the date of determination of fair market value and (y) the number of shares of common stock into which each Share is convertible at
the time of such exercise, as applicable; or 
 (iii)  if the Warrant is exercised in connection with the
Company’s initial public offering of common stock, the fair market value per Share shall be the product of (x) the per share offering price to the public of the Company’s initial public offering and (y) the number of shares of
common stock into which each Share is convertible at the time of such exercise, as applicable. 
 (c)  Stock
Certificates. The rights under this Warrant shall be deemed to have been exercised and the Shares issuable upon such exercise shall be deemed to have been issued immediately prior to the close of business on the date this Warrant is
exercised in accordance with its terms, and the person entitled to receive the Shares issuable upon such exercise shall be treated for all purposes as the holder of record of such Shares as of the close of business on such date. As promptly as
reasonably practicable on or after such date, the Company shall issue and deliver to the person or persons entitled to receive the same a certificate or certificates for that number of shares issuable upon such exercise. In the event that the rights
under this Warrant are exercised in part and have not expired, the Company shall execute and deliver a new Warrant reflecting the number of Shares that remain subject to this Warrant. 

(d)  No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued
upon the exercise of the rights under this Warrant. In lieu of such fractional share to which the Holder would otherwise be entitled, the Company shall make a cash payment equal to the Exercise Price multiplied by such fraction. 

(e)  Automatic Exercise. If the Holder of this Warrant has not elected to exercise this Warrant prior to
expiration of this Warrant pursuant to Section 8, then this Warrant shall automatically (without any act on the part of the Holder) be exercised pursuant to Section 2(b) effective immediately prior to the expiration of the Warrant to the
extent such net issue exercise would result in the issuance of Shares, unless Holder shall earlier provide written notice to the Company that the Holder desires that this Warrant expire unexercised. If this Warrant is automatically exercised, the
Company shall notify the Holder of the automatic exercise as soon as reasonably practicable, and the Holder shall surrender the Warrant to the Company in accordance with the terms hereof. 

  
 - 3 -

 (f)  Reservation of Stock. The Company agrees during
the term the rights under this Warrant are exercisable to take all reasonable action to reserve and keep available from its authorized and unissued shares of Series E-1 preferred stock for the purpose of effecting the exercise of this Warrant
such number of shares (and shares of common stock for issuance on conversion of such shares) as shall from time to time be sufficient to effect the exercise of the rights under this Warrant; and if at any time the number of authorized but unissued
shares of Series E-1 preferred stock (and shares of common stock for issuance on conversion of such shares) shall not be sufficient for purposes of the exercise of this Warrant in accordance with its terms and the conversion of the Shares,
without limitation of such other remedies as may be available to the Holder, the Company will use all reasonable efforts to take such corporate action as may, in the opinion of counsel, be necessary to increase its authorized and unissued shares of
its Series E-1 preferred stock (and shares of common stock for issuance on conversion of such shares) to a number of shares as shall be sufficient for such purposes. The Company represents and warrants that all shares that may be issued upon
the exercise of this Warrant will, when issued in accordance with the terms hereof, be validly issued, fully paid and nonassessable. 
 3.    Replacement of the Warrant. Subject to the receipt of evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in
the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and substance to the Company or, in the case of mutilation, on surrender and cancellation of this Warrant, the Company at the expense of
the Holder shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor and amount. 
 4.
    Transfer of the Warrant. 
 (a)  Warrant Register. The
Company shall maintain a register (the “Warrant Register”) containing the name and address of the Holder or Holders. Until this Warrant is transferred on the Warrant Register in accordance herewith, the Company may treat the
Holder as shown on the Warrant Register as the absolute owner of this Warrant for all purposes, notwithstanding any notice to the contrary. Any Holder of this Warrant (or of any portion of this Warrant) may change its address as shown on the Warrant
Register by written notice to the Company requesting a change. 
 (b)  Warrant Agent.
The Company may appoint an agent for the purpose of maintaining the Warrant Register referred to in Section 4(a), issuing the Shares or other securities then issuable upon the exercise of the rights under this Warrant, exchanging this Warrant,
replacing this Warrant or conducting related activities. 
 (c)  Transferability of the
Warrant. Subject to the provisions of this Warrant with respect to compliance with the Securities Act of 1933, as amended (the “Securities Act”) and limitations on assignments and transfers, including without
limitation compliance with the restrictions on transfer set forth in Section 5, title to this Warrant may be transferred by endorsement (by the transferor and the transferee executing the assignment form attached as Exhibit B (the
“Assignment Form”)) and delivery in the same manner as a negotiable instrument transferable by endorsement and delivery. 
 (d)  Exchange of the Warrant upon a Transfer. On surrender of this Warrant (and a properly endorsed Assignment Form) for exchange, subject to the provisions of this Warrant with
respect to compliance with the Securities Act and limitations on assignments and transfers, the Company shall issue to or on the order of the Holder a new warrant or warrants of like tenor, in the name of the Holder or as the Holder (on payment by
the Holder of any applicable transfer taxes) may direct, for the number of shares issuable upon exercise hereof, and the Company shall register any such transfer upon the Warrant Register. This Warrant (and the securities issuable upon exercise of
the rights under this Warrant) must be surrendered 

  
 - 4 -

 
to the Company or its warrant or transfer agent, as applicable, as a condition precedent to the sale, pledge, hypothecation or other transfer of any interest in any of the securities represented
hereby. 
 (e)  Taxes. In no event shall the Company be required to pay any tax which
may be payable in respect of any transfer involved in the issue and delivery of any certificate in a name other than that of the Holder, and the Company shall not be required to issue or deliver any such certificate unless and until the person or
persons requesting the issue thereof shall have paid to the Company the amount of such tax or shall have established to the satisfaction of the Company that such tax has been paid or is not payable. 

5.    Restrictions on Transfer of the Warrant and Shares; Compliance with Securities Laws. By
acceptance of this Warrant, the Holder agrees to comply with the following: 
 (a)  Restrictions
on Transfers. Any transfer of this Warrant or the Shares or the shares of common stock issuable upon conversion of the Shares (the “Securities”) must be in compliance with all applicable federal and state securities
laws. The Holder agrees not to make any sale, assignment, transfer, pledge or other disposition of all or any portion of the Securities, or any beneficial interest therein, unless and until the transferee thereof has agreed in writing for the
benefit of the Company to take and hold such Securities subject to, and to be bound by, the terms and conditions set forth in this Warrant to the same extent as if the transferee were the original Holder hereunder. 

(b)  Investment Representation Statement. Unless the rights under this Warrant are exercised
pursuant to an effective registration statement under the Securities Act that includes the Shares with respect to which the Warrant was exercised, it shall be a condition to any exercise of the rights under this Warrant that the Holder shall have
confirmed to the satisfaction of the Company in writing, substantially in the form of Exhibit A-1, that the Shares so purchased are being acquired solely for the Holder’s own account and not as a nominee for any other party, for
investment and not with a view toward distribution or resale and that the Holder shall have confirmed such other matters related thereto as may be reasonably requested by the Company. 

(c)  Securities Law Legend. The Securities shall (unless otherwise permitted by the provisions of
this Warrant) be stamped or imprinted with a legend substantially similar to the following (in addition to any legend required by state securities laws): 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES. THESE SECURITIES MAY NOT BE
OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS IN ACCORDANCE WITH APPLICABLE REGISTRATION REQUIREMENTS OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES
MAY REQUIRE AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS. THIS CERTIFICATE MUST BE SURRENDERED TO THE
COMPANY OR ITS TRANSFER AGENT AS A CONDITION PRECEDENT TO THE SALE, TRANSFER, PLEDGE OR HYPOTHECATION OF ANY INTEREST IN ANY OF THE SECURITIES REPRESENTED HEREBY. 

(d)  Market Stand-off Legend. The Shares and common stock issued upon exercise hereof or
conversion thereof shall also be stamped or imprinted with a legend in substantially the following form: 

  
 - 5 -

 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY
AND RESALE, INCLUDING A LOCK-UP PERIOD IN THE EVENT OF A PUBLIC OFFERING, AS SET FORTH IN THE WARRANT PURSUANT TO WHICH THESE SHARES WERE ISSUED, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE COMPANY. 

(e)  Instructions Regarding Transfer Restrictions. The Holder consents to the Company making a
notation on its records and giving instructions to any transfer agent in order to implement the restrictions on transfer established in this Section 5. 
 (f)  Removal of Legend. The legend referring to federal and state securities laws identified in Section 5(c) stamped on a certificate evidencing the Shares (and the common
stock issuable upon conversion thereof) and the stock transfer instructions and record notations with respect to such securities shall be removed and the Company shall issue a certificate without such legend to the holder of such securities if
(i) such securities are registered under the Securities Act, or (ii) such holder provides the Company with an opinion of counsel reasonably acceptable to the Company to the effect that a sale or transfer of such securities may be made
without registration or qualification. 
 6.    Adjustments. Subject to the
expiration of this Warrant pursuant to Section 8, the number and kind of shares purchasable hereunder and the Exercise Price therefor are subject to adjustment from time to time, as follows: 

(a)  Merger or Reorganization.    If at any time there shall be any
reorganization, recapitalization, merger or consolidation (a “Reorganization”) involving the Company (other than as otherwise provided for herein or as would cause the expiration of this Warrant under Section 8) in which
shares of the Company’s stock are converted into or exchanged for securities, cash or other property, then, as a part of such Reorganization, lawful provision shall be made so that the Holder shall thereafter be entitled to receive upon
exercise of this Warrant, the kind and amount of securities, cash or other property of the successor corporation resulting from such Reorganization, equivalent in value to that which a holder of the Shares deliverable upon exercise of this Warrant
would have been entitled in such Reorganization if the right to purchase the Shares hereunder had been exercised immediately prior to such Reorganization. In any such case, appropriate adjustment (as determined in good faith by the Board of
Directors of the successor corporation) shall be made in the application of the provisions of this Warrant with respect to the rights and interests of the Holder after such Reorganization to the end that the provisions of this Warrant shall be
applicable after the event, as near as reasonably may be, in relation to any shares or other securities deliverable after that event upon the exercise of this Warrant. 

(b)  Reclassification of Shares. If the securities issuable upon exercise of this Warrant are
changed into the same or a different number of securities of any other class or classes by reclassification, capital reorganization, conversion of all outstanding shares of the relevant class or series (other than as would cause the expiration of
this Warrant pursuant to Section 8) or otherwise (other than as otherwise provided for herein) (a “Reclassification”), then, in any such event, in lieu of the number of Shares which the Holder would otherwise have been
entitled to receive, the Holder shall have the right thereafter to exercise this Warrant for a number of shares of such other class or classes of stock that a holder of the number of securities deliverable upon exercise of this Warrant immediately
before that change would have been entitled to receive in such Reclassification, all subject to further adjustment as provided herein with respect to such other shares. 

(c)  Subdivisions and Combinations. In the event that the outstanding shares of the securities
issuable upon exercise of this Warrant are subdivided (by stock split, by payment of a stock dividend or otherwise) into a greater number of shares of such securities, the number of Shares issuable upon exercise of the rights under this Warrant
immediately prior to such subdivision shall, concurrently with the effectiveness 

  
 - 6 -

 
of such subdivision, be proportionately increased, and the Exercise Price shall be proportionately decreased, and in the event that the outstanding shares of the securities issuable upon exercise
of this Warrant are combined (by reclassification or otherwise) into a lesser number of shares of such securities, the number of Shares issuable upon exercise of the rights under this Warrant immediately prior to such combination shall, concurrently
with the effectiveness of such combination, be proportionately decreased, and the Exercise Price shall be proportionately increased. 
 (d)  Redemption. In the event that all of the outstanding shares of the securities issuable upon exercise of this Warrant are redeemed in accordance with the Company’s
certificate of incorporation, this Warrant shall thereafter be exercisable for a number of shares of the Company’s common stock equal to the number of shares of common stock that would have been received if this Warrant had been exercised in
full immediately prior to such redemption and the Series E-1 preferred stock received thereupon had been simultaneously converted into common stock. 
 (e)  Notice of Adjustments. Upon any adjustment in accordance with this Section 6, the Company shall give notice thereof to the Holder, which notice shall state the event
giving rise to the adjustment, the Exercise Price as adjusted and the number of securities or other property purchasable upon the exercise of the rights under this Warrant, setting forth in reasonable detail the method of calculation of each. The
Company shall, upon the written request of any Holder, furnish or cause to be furnished to such Holder a certificate setting forth (i) such adjustments, (ii) the Exercise Price at the time in effect and (iii) the number of securities
and the amount, if any, of other property that at the time would be received upon exercise of this Warrant. 

7.    Notification of Certain Events. Prior to the expiration of this Warrant pursuant to
Section 8, in the event that the Company shall authorize: 
 (a)  the issuance of any dividend or
other distribution on the capital stock of the Company (other than (i) dividends or distributions otherwise provided for in Section 6, (ii) repurchases of common stock issued to or held by employees, officers, directors or consultants
of the Company or its subsidiaries upon termination of their employment or services pursuant to agreements providing for the right of said repurchase; (iii) repurchases of common stock issued to or held by employees, officers, directors or
consultants of the Company or its subsidiaries pursuant to rights of first refusal or first offer contained in agreements providing for such rights; or (iv) repurchases of capital stock of the Company in connection with the settlement of
disputes with any stockholder), whether in cash, property, stock or other securities; 
 (b)  the
voluntary liquidation, dissolution or winding up of the Company; or 
 (c)  any transaction resulting
in the expiration of this Warrant pursuant to Section 8(b) or 8(c); 
 the Company shall send to the Holder of this Warrant
at least ten (10) days prior written notice of the date on which a record shall be taken for any such dividend or distribution specified in clause (a) or the expected effective date of any such other event specified in clause (b) or
(c), as applicable. The notice provisions set forth in this section may be shortened or waived prospectively or retrospectively by the consent of the holders of a majority of the Shares issuable upon exercise of the rights under the Warrants.

 8.    Expiration of the Warrant. This Warrant shall expire and shall no longer be
exercisable as of the earlier of: 
 (a)  5:00 p.m., Pacific time, on January 6, 2021;

  
 - 7 -

 (b)  (i) the acquisition of the Company by another entity by
means of any transaction or series of related transactions (including, without limitation, any stock acquisition, reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing the domicile of the
Company) other than a transaction or series of transactions in which the holders of the voting securities of the Company outstanding immediately prior to such transaction or series of transactions continue to retain (either by such voting securities
remaining outstanding or by such voting securities being converted into voting securities of the surviving entity), as a result of shares in the Company held by such holders prior to such transaction, at least fifty percent (50%) of the total
voting power represented by the voting securities of the Company or such surviving entity outstanding immediately after such transaction or series of transactions; or (ii) a sale, transfer, lease or other conveyance of all or substantially all
of the assets of the Company; or 
 (c)  immediately prior to the closing of a firm commitment
underwritten initial public offering on Form S-1 (or successor form) filed under the Securities Act covering the offer and sale of the Company’s common stock; provided, however, that all outstanding shares of Preferred Stock of
the Company shall convert either automatically or though stockholder consent or vote, into shares of Common Stock in connection with such initial public offering. 

9.    No Rights as a Stockholder. Nothing contained herein shall entitle the Holder to any
rights as a stockholder of the Company or to be deemed the holder of any securities that may at any time be issuable on the exercise of the rights hereunder for any purpose nor shall anything contained herein be construed to confer upon the Holder,
as such, any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold consent to any corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value or change of stock to no par value, consolidation, merger, conveyance or otherwise) or to receive notice of meetings, or to receive dividends or subscription rights or any other rights of a stockholder
of the Company until the rights under the Warrant shall have been exercised and the Shares purchasable upon exercise of the rights hereunder shall have become deliverable as provided herein. 

10.  Market Stand-off. The Holder of this Warrant hereby agrees that such Holder shall not sell or
otherwise transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, of any common stock (or other securities) of the Company held by the Holder
(other than those included in the registration) during the one hundred eighty (180) day period following the effective date of the registration statement for the Company’s initial public offering filed under the Securities Act (or such
other period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on (i) the publication or other distribution of research reports and (ii) analyst recommendations and opinions, including, but not
limited to, the restrictions contained in NASD Rule 2711(f)(4) or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto). The obligations described in this section shall not apply to a registration relating solely to
employee benefit plans on Form S-l or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a transaction on Form S-4 or similar forms that may be promulgated in the future. The Company may impose
stop-transfer instructions and may stamp each certificate with a legend as substantially set forth in Section 5(d) with respect to the shares of common stock (or other securities) subject to the foregoing restriction until the end of such one
hundred eighty (180) day (or other) period. The Holder agrees to execute a market stand-off agreement with the underwriters in the offering in customary form consistent with the provisions of this section. 

11.  Representations and Warranties of the Holder. By acceptance of this Warrant, the Holder represents
and warrants to the Company as follows: 
 (a)  No Registration.  The Holder
understands that the Securities have not been, and will not be, registered under the Securities Act by reason of a specific exemption from the registration provisions of 

  
 - 8 -

 
the Securities Act, the availability of which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of the Holder’s representations as
expressed herein or otherwise made pursuant hereto. 
 (b)  Investment
Intent.  The Holder is acquiring the Securities for investment for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, any distribution thereof. The Holder has no present intention
of selling, granting any participation in, or otherwise distributing the Securities, nor does it have any contract, undertaking, agreement or arrangement for the same. 

(c)  Investment Experience.  The Holder has substantial experience in evaluating and
investing in private placement transactions of securities in companies similar to the Company, and has such knowledge and experience in financial or business matters so that it is capable of evaluating the merits and risks of its investment in the
Company and protecting its own interests. 
 (d)  Speculative Nature of
Investment.  The Holder understands and acknowledges that its investment in the Company is highly speculative and involves substantial risks. The Holder can bear the economic risk of its investment and is able, without impairing
its financial condition, to hold the Securities for an indefinite period of time and to suffer a complete loss of its investment. 
 (e)  Access to Data.  The Holder has had an opportunity to ask questions of officers of the Company, which questions were answered to its satisfaction. The Holder
believes that it has received all the information that it considers necessary or appropriate for deciding whether to acquire the Securities. The Holder understands that any such discussions, as well as any information issued by the Company, were
intended to describe certain aspects of the Company’s business and prospects, but were not necessarily a thorough or exhaustive description. The Holder acknowledges that any business plans prepared by the Company have been, and continue to be,
subject to change and that any projections included in such business plans or otherwise are necessarily speculative in nature, and it can be expected that some or all of the assumptions underlying the projections will not materialize or will vary
significantly from actual results. 
 (f)  Accredited Investor.  The Holder is
an “accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated by the Securities and Exchange Commission and agrees to submit to the Company such further assurances of such status as may be reasonably
requested by the Company. 
 (g)  Residency.  The residency of the Holder (or,
in the case of a partnership or corporation, such entity’s principal place of business) is correctly set forth on the signature page hereto. 
 (h)  Restrictions on Resales.  The Holder acknowledges that the Securities must be held indefinitely unless subsequently registered under the Securities Act or an
exemption from such registration is available. The Holder is aware of the provisions of Rule 144 promulgated under the Securities Act, which permit resale of shares purchased in a private placement subject to the satisfaction of certain
conditions, which may include, among other things, the availability of certain current public information about the Company; the resale occurring not less than a specified period after a party has purchased and paid for the security to be sold; the
number of shares being sold during any three-month period not exceeding specified limitations; the sale being effected through a “broker’s transaction,” a transaction directly with a “market maker” or a “riskless
principal transaction” (as those terms are defined in the Securities Act or the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder); and the filing of a Form 144 notice, if applicable. The Holder
acknowledges and understands that the Company may not be satisfying the current public information requirement of Rule 144 at the time the Holder wishes to sell the Securities and that, in such event, the Holder may be precluded from selling
the Securities under Rule 144 even if the other applicable requirements of Rule 144 have been satisfied. The Holder acknowledges that, in the event the applicable requirements of Rule 144 are not met, registration under the Securities
Act or an 

  
 - 9 -

 
exemption from registration will be required for any disposition of the Securities. The Holder understands that, although Rule 144 is not exclusive, the Securities and Exchange Commission
has expressed its opinion that persons proposing to sell restricted securities received in a private offering other than in a registered offering or pursuant to Rule 144 will have a substantial burden of proof in establishing that an exemption
from registration is available for such offers or sales and that such persons and the brokers who participate in the transactions do so at their own risk. 
 (i)  No Public Market.  The Holder understands and acknowledges that no public market now exists for any of the securities issued by the Company and that the Company has
made no assurances that a public market will ever exist for the Company’s securities. 

(j)  Brokers and Finders.  The Holder has not engaged any brokers, finders or agents in
connection with the Securities, and the Company has not incurred nor will incur, directly or indirectly, as a result of any action taken by the Holder, any liability for brokerage or finders’ fees or agents’ commissions or any similar
charges in connection with the Securities. 
 (k)  Legal Counsel.  The Holder
has had the opportunity to review this Warrant, the exhibits and schedules attached hereto and the transactions contemplated by this Warrant with its own legal counsel. The Holder is not relying on any statements or representations of the Company or
its agents for legal advice with respect to this investment or the transactions contemplated by this Warrant. 

(l)  Tax Advisors.  The Holder has reviewed with its own tax advisors the U.S. federal,
state and local and non-U.S. tax consequences of this investment and the transactions contemplated by this Warrant. With respect to such matters, the Holder relies solely on any such advisors and not on any statements or representations of the
Company or any of its agents, written or oral. The Holder understands that it (and not the Company) shall be responsible for its own tax liability that may arise as a result of the Holder’s receipt of this Warrant and the transactions
contemplated by this Warrant. 
 12.  Miscellaneous. 

(a)  Amendments.  Except as expressly provided herein, neither this Warrant nor any
term hereof may be amended, waived, discharged or terminated other than by a written instrument referencing this Warrant and signed by the Company and the holders of warrants representing not less than a majority of the Shares issuable upon exercise
of any and all outstanding Warrants, which majority does not need to include the consent of the Holder. Any amendment, waiver, discharge or termination effected in accordance with this Section 12(a) shall be binding upon each holder of the
Warrants, each future holder of such Warrants and the Company; provided, however, that no special consideration or inducement may be given to any such holder in connection with such consent that is not given ratably to all such holders, and
that such amendment must apply to all such holders equally and ratably in accordance with the number of shares of the Company’s Series E-1 preferred stock issuable upon exercise of the Warrants. The Company shall promptly give notice to all
holders of Warrants of any amendment effected in accordance with this Section 12(a). 

(b)  Waivers.  No waiver of any single breach or default shall be deemed a waiver of
any other breach or default theretofore or thereafter occurring. 

(c)  Notices.  All notices and other communications required or permitted hereunder
shall be in writing and shall be mailed by registered or certified mail, postage prepaid, sent by facsimile or electronic mail (if to the Holder) or otherwise delivered by hand, messenger or courier service addressed: 

(i)      if to the Holder, to the Holder at the Holder’s address, facsimile number or electronic mail
address as shown in the Company’s records, as may be updated in accordance with the 

  
 - 10 -

 
provisions hereof, or until any such Holder so furnishes an address, facsimile number or electronic mail address to the Company, then to and at the address, facsimile number or electronic mail
address of the last holder of this Warrant for which the Company has contact information in its records; or 

(ii)      if to the Company, to the attention of the President or Chief Financial Officer of the Company
at the Company’s address as shown on the signature page hereto, or at such other address as the Company shall have furnished to the Holder, with a copy to Robert F. Kornegay, Wilson Sonsini Goodrich & Rosati, P.C., 650 Page Mill Road,
Palo Alto, California 94304. 
 Each such notice or other communication shall for all purposes of this Warrant
be treated as effective or having been given (i) if delivered by hand, messenger or courier service, when delivered, or (ii) if sent by mail, at the earlier of its receipt or 72 hours after the same has been deposited in a regularly
maintained receptacle for the deposit of the United States mail, addressed and mailed as aforesaid, or (iii) if sent by facsimile, upon confirmation of facsimile transfer or, if sent by electronic mail, upon confirmation of delivery when
directed to the relevant electronic mail address. In the event of any conflict between the Company’s books and records and this Warrant or any notice delivered hereunder, the Company’s books and records will control absent fraud or error.

 (d)  Governing Law.  This Warrant and all actions arising out of or in
connection with this Warrant shall be governed by and construed in accordance with the laws of the State of California, without regard to the conflicts of law provisions of the State of California, or of any other state. 

(e)  Jurisdiction and Venue.  Each of the Holder and the Company irrevocably consents
to the exclusive jurisdiction and venue of any court within Santa Clara County, State of California, in connection with any matter based upon or arising out of this Warrant or the matters contemplated herein, and agrees that process may be served
upon them in any manner authorized by the laws of the State of California for such persons. 

(f)  Titles and Subtitles.  The titles and subtitles used in this Warrant are used for
convenience only and are not to be considered in construing or interpreting this Warrant. All references in this Warrant to sections, paragraphs and exhibits shall, unless otherwise provided, refer to sections and paragraphs hereof and exhibits
attached hereto. 
 (g)  Severability.  If any provision of this Warrant
becomes or is declared by a court of competent jurisdiction to be illegal, unenforceable or void, portions of such provision, or such provision in its entirety, to the extent necessary, shall be severed from this Warrant, and such illegal,
unenforceable or void provision shall be replaced with a valid and enforceable provision that will achieve, to the extent possible, the same economic, business and other purposes of the illegal, unenforceable or void provision. The balance of this
Warrant shall be enforceable in accordance with its terms. 
 (h)  Waiver of Jury Trial.
EACH OF THE HOLDER AND THE COMPANY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING (WHETHER BASED ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATED TO THIS
WARRANT. If the waiver of jury trial set forth in this paragraph is not enforceable, then any claim or cause of action arising out of or relating to this Warrant shall be settled by judicial reference pursuant to California Code of
Civil Procedure Section 638 et seq. before a referee sitting without a jury, such referee to be mutually acceptable to the parties or, if no agreement is reached, by a referee appointed by the Presiding Judge of the California Superior
Court for Santa Clara County. This paragraph shall not restrict the Holder or the Company from exercising remedies under the Uniform Commercial Code or from exercising pre-judgment remedies under applicable law. 

  
 - 11 -

 (i)  California Corporate Securities
Law.  THE SALE OF THE SECURITIES THAT ARE THE SUBJECT OF THIS WARRANT HAS NOT BEEN QUALIFIED WITH THE COMMISSIONER OF CORPORATIONS OF THE STATE OF CALIFORNIA AND THE ISSUANCE OF SUCH SECURITIES OR THE PAYMENT OR RECEIPT OF ANY PART
OF THE CONSIDERATION THEREFOR PRIOR TO SUCH QUALIFICATION IS UNLAWFUL, UNLESS THE SALE OF SECURITIES IS EXEMPT FROM QUALIFICATION BY SECTION 25100, 25102, OR 25105 OF THE CALIFORNIA CORPORATIONS CODE. THE RIGHTS OF ALL PARTIES TO THIS WARRANT
ARE EXPRESSLY CONDITIONED UPON THE QUALIFICATION BEING OBTAINED, UNLESS THE SALE IS SO EXEMPT. 

(j)  Saturdays, Sundays and Holidays.  If the last or appointed day for the taking of
any action or the expiration of any right required or granted herein shall be a Saturday, Sunday or U.S. federal holiday, then such action may be taken or such right may be exercised on the next succeeding day that is not a Saturday, Sunday or U.S.
federal holiday. 
 (k)  Rights and Obligations Survive Exercise of the
Warrant.  Except as otherwise provided herein, the rights and obligations of the Company and the Holder under this Warrant shall survive exercise of this Warrant. 

(l)   Entire Agreement.  Except as expressly set forth herein, this Warrant
(including the exhibits attached hereto) constitutes the entire agreement and understanding of the Company and the Holder with respect to the subject matter hereof and supersede all prior agreements and understandings relating to the subject matter
hereof. 
 *  *  *  *  * 

  
 - 12 -

 The Company and the Holder sign this Warrant as of the date stated on the
first page. 
  

			
	 FLUIDIGM CORPORATION,

	 a Delaware corporation

		
	 By:
	 	  

		 	 Gajus V. Worthington,

		 	 President and Chief Executive Officer

	
	 Address:

		
		 	 7000 Shoreline Court, Suite 100

		 	 South San Francisco, CA 94080

  

			
	 AGREED AND ACKNOWLEDGED,

	
	
[                             
   ]

		
	 By:
	 	  

		
	 Name:
	 	  

		
	 Title:
	 	  

			
		
	 Address:
	 	
		
		 	  

		
		 	  

		
		 	  

			
		
	 Fax number:
	 	  

		
	 Email address:
	 	  

[Signature Page to Warrant to Purchase Shares of Series E-1 Preferred Stock of Fluidigm Corporation] 

 EXHIBIT A 
 NOTICE OF EXERCISE 
  

	To:	Fluidigm Corporation, a Delaware corporation (the “Company”) 

 

	Attention:	President & CEO 

  

	(1)	Exercise. The undersigned elects to purchase the following pursuant to the terms of the attached warrant: 

 

					
		 	 Number of shares:
	  	  

			
		 	 Type of security:
	  	  

 

	(2)	Method of Exercise. The undersigned elects to exercise the attached warrant pursuant to: 

 

	 	 ̈	A cash payment and tenders herewith payment of the purchase price for such shares in full, together with all applicable transfer taxes, if any.

  

	 	 ̈	The net issue exercise provisions of Section 2(b) of the attached warrant. 

 

	(3)	Stock Certificate. Please issue a certificate or certificates representing the shares in the name of: 

 

	 	 ̈	The undersigned 

  

							
		 	  ̈
	 	 Other—Name:   
	  	  

				
		 		 	Address:	  	  

				
		 		 		  	  

 

	(4)	Unexercised Portion of the Warrant. Please issue a new warrant for the unexercised portion of the attached warrant in the name of: 

 

	 	 ̈	The undersigned 

  

							
		 	  ̈
	 	 Other—Name:   
	  	  

				
		 		 	Address:	  	  

				
		 		 		  	  

				
		 	  ̈
	 	 Not applicable
	  	

  

	(5)	 Investment Intent. The undersigned represents and warrants that the aforesaid shares are being acquired for investment for its own account, not
as a nominee or agent, and not with a view to, or for resale in connection with, the distribution thereof, and that the undersigned has no present intention of selling, granting any participation in, or otherwise distributing the shares, nor does it
have any contract, undertaking, agreement or arrangement for the same, and all representations and warranties 

  
 A-1

	 	 
of the undersigned set forth in Section 11 of the attached warrant are true and correct as of the date hereof. 

 

	(6)	Investment Representation Statement and Market Stand-Off Agreement. The undersigned has executed, and delivers herewith, an Investment Representation Statement
and Market Stand-Off Agreement in a form substantially similar to the form attached to the warrant as Exhibit A-1. 

  

	(7)	Consent to Receipt of Electronic Notice. Subject to the limitations set forth in Delaware General Corporation Law §232(e), the undersigned consents to the
delivery of any notice to stockholders given by the Company under the Delaware General Corporation Law or the Company’s certificate of incorporation or bylaws by (i) facsimile telecommunication to the facsimile number provided below (or to
any other facsimile number for the undersigned in the Company’s records), (ii) electronic mail to the electronic mail address provided below (or to any other electronic mail address for the undersigned in the Company’s records),
(iii) posting on an electronic network together with separate notice to the undersigned of such specific posting or (iv) any other form of electronic transmission (as defined in the Delaware General Corporation Law) directed to the
undersigned. This consent may be revoked by the undersigned by written notice to the Company and may be deemed revoked in the circumstances specified in Delaware General Corporation Law §232. 

 

	
	  

	(Print name of the warrant holder)
	
	  

	(Signature)
	
	  

	(Name and title of signatory, if applicable)
	
	  

	(Date)
	
	  

	(Fax number)
	
	  

	(Email address)

[Signature Page to Notice of Exercise] 

  
 A-2

 EXHIBIT A-l 

INVESTMENT REPRESENTATION STATEMENT 
 AND 
 MARKET STAND-OFF AGREEMENT 

 

							
	 INVESTOR:
	  	  
	  	
		
	 COMPANY:
	  	 FLUIDIGM CORPORATION, A DELAWARE CORPORATION

		
	 SECURITIES:
	  	 THE WARRANT ISSUED ON JANUARY 6, 2011 (THE “WARRANT”) AND THE SECURITIES ISSUED OR ISSUABLE UPON EXERCISE THEREOF
(INCLUDING UPON SUBSEQUENT CONVERSION OF THOSE SECURITIES)

				
	 DATE:
	  	  
	  		  	

 In connection with the purchase or acquisition of the above-listed Securities, the
undersigned Investor represents and warrants to, and agrees with, the Company as follows: 

1.            No Registration. The Investor
understands that the Securities have not been, and will not be, registered under the Securities Act of 1933, as amended (the “Securities Act”), by reason of a specific exemption from the registration provisions of the
Securities Act, the availability of which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of the Investor’s representations as expressed herein or otherwise made pursuant hereto.

 2.            Investment Intent. The
Investor is acquiring the Securities for investment for its own account, not as a nominee or agent, and not with a view to, or for resale in connection with, any distribution thereof. The Investor has no present intention of selling, granting any
participation in, or otherwise distributing the Securities, nor does it have any contract, undertaking, agreement or arrangement for the same. 
 3.            Investment Experience. The Investor has substantial experience in evaluating and investing in private placement
transactions of securities in companies similar to the Company, and has such knowledge and experience in financial or business matters so that it is capable of evaluating the merits and risks of its investment in the Company and protecting its own
interests. 
 4.            Speculative Nature of
Investment. The Investor understands and acknowledges that its investment in the Company is highly speculative and involves substantial risks. The Investor can bear the economic risk of its investment and is able, without impairing its financial
condition, to hold the Securities for an indefinite period of time and to suffer a complete loss of its investment. 
 5.            Access to Data. The Investor has had an opportunity to ask questions of officers of the Company, which questions were
answered to its satisfaction. The Investor believes that it has received all the information that it considers necessary or appropriate for deciding whether to acquire the Securities. The Investor understands that any such discussions, as well as
any information issued by the Company, were intended to describe certain aspects of the Company’s business and prospects, but were not necessarily a thorough or exhaustive description. The Investor acknowledges that any business plans prepared
by the Company have been, and continue to be, subject to change and that any projections included in such business plans or otherwise are necessarily speculative in nature, and it can be expected that some or all of the assumptions underlying the
projections will not materialize or will vary significantly from actual results. 

  
 A-1-1

6.            Accredited Investor. The Investor is an
“accredited investor” within the meaning of Regulation D, Rule 501(a), promulgated by the Securities and Exchange Commission and agrees to submit to the Company such further assurances of such status as may be reasonably
requested by the Company. 

7.            Residency. The residency of the Investor
(or, in the case of a partnership or corporation, such entity’s principal place of business) is correctly set forth on the signature page hereto. 
 8.            Restrictions on Resales. The Investor acknowledges that the Securities must be held indefinitely unless subsequently
registered under the Securities Act or an exemption from such registration is available. The Investor is aware of the provisions of Rule 144 promulgated under the Securities Act, which permit resale of shares purchased in a private placement subject
to the satisfaction of certain conditions, which may include, among other things, the availability of certain current public information about the Company; the resale occurring not less than a specified period after a party has purchased and paid
for the security to be sold; the number of shares being sold during any three-month period not exceeding specified limitations; the sale being effected through a “broker’s transaction,” a transaction directly with a “market
maker” or a “riskless principal transaction” (as those terms are defined in the Securities Act or the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder); and the filing of a Form
144 notice, if applicable. The Investor acknowledges and understands that the Company may not be satisfying the current public information requirement of Rule 144 at the time the Investor wishes to sell the Securities and that, in such event, the
Investor may be precluded from selling the Securities under Rule 144 even if the other applicable requirements of Rule 144 have been satisfied. The Investor acknowledges that, in the event the applicable requirements of Rule 144 are not met,
registration under the Securities Act or an exemption from registration will be required for any disposition of the Securities. The Investor understands that, although Rule 144 is not exclusive, the Securities and Exchange Commission has expressed
its opinion that persons proposing to sell restricted securities received in a private offering other than in a registered offering or pursuant to Rule 144 will have a substantial burden of proof in establishing that an exemption from registration
is available for such offers or sales and that such persons and the brokers who participate in the transactions do so at their own risk. 
 9.            No Public Market. The Investor understands and acknowledges that no public market now exists for any of the securities
issued by the Company and that the Company has made no assurances that a public market will ever exist for the Company’s securities. 
 10.          Brokers and Finders. The Investor has not engaged any brokers, finders or agents in connection with the Securities, and the Company
has not incurred nor will incur, directly or indirectly, as a result of any action taken by the Investor, any liability for brokerage or finders’ fees or agents’ commissions or any similar charges in connection with the Securities.

 11.          Legal Counsel. The Investor has had the
opportunity to review the Warrant, the exhibits and schedules attached thereto and the transactions contemplated by the Warrant with its own legal counsel. The Investor is not relying on any statements or representations of the Company or its agents
for legal advice with respect to this investment or the transactions contemplated by the Warrant. 

12.          Tax Advisors. The Investor has reviewed with
its own tax advisors the U.S. federal, state and local and non-U.S. tax consequences of this investment and the transactions contemplated by the Warrant. With respect to such matters, the Investor relies solely on such advisors and not on any
statements or representations of the Company or any of its agents, written or oral. The Investor understands that it (and not the Company) shall be responsible for its own tax liability that may arise as a result of this investment or the
transactions contemplated by the Warrant. 

  
 A-1-2

 13.          Market
Stand-off. The Investor hereby agrees that the Investor shall not sell or otherwise transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale,
of any common stock (or other securities) of the Company held by the Investor (other than those included in the registration) during the one hundred eighty (180) day period following the effective date of the registration statement for the
Company’s initial public offering filed under the Securities Act (or such other period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on (i) the publication or other distribution of research
reports and (ii) analyst recommendations and opinions, including, but not limited to, the restrictions contained in NASD Rule 2711(f)(4) or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto). The obligations described in
this section shall not apply to a registration relating solely to employee benefit plans on Form S-l or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a transaction on Form S-4 or similar forms
that may be promulgated in the future. The Company may impose stop-transfer instructions and may stamp each certificate with a legend as substantially set forth in Section 5(e) with respect to the shares of common stock (or other securities)
subject to the foregoing restriction until the end of such one hundred eighty (180) day (or other) period. The Investor agrees to execute a market stand-off agreement with the underwriters in the offering in customary form consistent with the
provisions of this section. 
 *  *  *  *  * 

  
 A-1-3

 The Investor is signing this Investment Representation Statement and Market
Stand-Off Agreement on the date first written above. 
  

	
	INVESTOR
	
	  

	(Print name of the investor)
	
	  

	(Signature)
	
	  

	(Name and title of signatory, if applicable)
	
	  

	(Street address)
	
	  

	(City, state and ZIP)

  
 A-1-4

 EXHIBIT B 
 ASSIGNMENT FORM 
  

							
	 ASSIGNOR:
	  	  
	  	
		
	 COMPANY:
	  	 FLUIDIGM CORPORATION, A DELAWARE CORPORATION

		
	 WARRANT:
	  	 THE WARRANT TO PURCHASE SHARES OF SERIES E-1 PREFERRED STOCK ISSUED ON JANUARY 6, 2011 (THE
“WARRANT”)

				
	 DATE:
	  	  
	  		  	

  

	(1)	Assignment. The undersigned registered holder of the Warrant (“Assignor”) assigns and transfers to the assignee named below
(“Assignee”) all of the rights of Assignor under the Warrant, with respect to the number of shares set forth below: 

  

					
	 Name of Assignee:
	 	  
	 	
			
	 Address of Assignee:
	 	  
	 	
			
		 	  
	 	

					
			
	 Number of Shares Assigned:
	 	  
	 	

 and does irrevocably constitute and appoint
                                        
as attorney to make such transfer on the books of Fluidigm Corporation, maintained for the purpose, with full power of substitution in the premises. 
  

	(2)	Obligations of Assignee. Assignee agrees to take and hold the Warrant and any shares of stock to be issued upon exercise of the rights thereunder (and any shares
issuable upon conversion thereof) (the “Securities”) subject to, and to be bound by, the terms and conditions set forth in the Warrant to the same extent as if Assignee were the original holder thereof.

  

	(3)	Investment Intent. Assignee represents and warrants that the Securities are being acquired for investment for its own account, not as a nominee or agent, and not
with a view to, or for resale in connection with, the distribution thereof, and that Assignee has no present intention of selling, granting any participation in, or otherwise distributing the shares, nor does it have any contract, undertaking,
agreement or arrangement for the same, and all representations and warranties set forth in Section 11 of the Warrant are true and correct as to Assignee as of the date hereof. 

 

	(4)	Investment Representation Statement and Market Stand-Off Agreement. Assignee has executed, and delivers herewith, an Investment Representation Statement and
Market Stand-Off Agreement in a form substantially similar to the form attached to the Warrant as Exhibit A-1. 

  
 B-1

 Assignor and Assignee are signing this Assignment Form on the date first set
forth above. 
  

					
	ASSIGNOR	 		 	ASSIGNEE
			
	  
	 		 	  

	(Print name of Assignor)	 		 	(Print name of Assignee)
			
	  
	 		 	  

	(Signature of Assignor)	 		 	(Signature of Assignee)
			
	  
	 		 	  

	(Print name of signatory, if applicable)	 		 	(Print name of signatory, if applicable)
			
	  
	 		 	  

	(Print title of signatory, if applicable)	 		 	(Print title of signatory, if applicable)
			
	 Address:
	 		 	 Address:

			
	  
	 		 	  

			
	  
	 		 	  

  
 B-2

 Exhibit C 
 FORM OF SECURITY AGREEMENT 

 THIS SECURITY AGREEMENT AND THE RIGHTS OF COLLATERAL AGENT AND THE INVESTORS HEREUNDER ARE
SUBJECT TO A SUBORDINATION AGREEMENT, DATED AS OF JANUARY 6, 2011, AMONG LIGHTHOUSE CAPITAL PARTNERS V, L.P., BRIDGE BANK, NATIONAL ASSOCIATION, THE COMPANY AND THE INVESTORS (THE “SUBORDINATION AGREEMENT”). 

SECURITY AGREEMENT 
 This Security Agreement (as amended, modified or otherwise supplemented from time to time, this “Security Agreement”), dated as of January 6, 2011, is executed by Fluidigm
Corporation, a Delaware corporation (together with its successors and assigns, “Company”), in favor of Collateral Agent (as herein defined) on behalf of the Investors listed on the signature pages hereof. 

RECITALS 
 A.            The Company and the Investors have entered into a Note and Warrant Purchase Agreement, dated as of the date hereof (the
“Purchase Agreement”), pursuant to which the Company has issued secured, subordinated promissory notes, dated as of the date hereof (as amended, modified or otherwise supplemented from time to time, (each a “Note”
and collectively, the “Notes”) in an aggregate principal amount of up to $5,000,000 in favor of the Investors. 
 B.            In order to induce each Investor to extend the credit evidenced by the Notes, Company has agreed to enter into this Security
Agreement and to grant Collateral Agent, for the benefit of itself and the Investors, the security interest in the Collateral described below. 
 AGREEMENT 
 NOW, THEREFORE, in consideration of the
above recitals and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, Company hereby agrees with Collateral Agent and the Investors as follows: 

1.    Definitions and Interpretation.    When used in this Security
Agreement, the following terms have the following respective meanings: 
 “Collateral” has the
meaning given to that term in Section 2 hereof. 
 “Intellectual Property”
means all intellectual and similar property of every kind and nature now owned or hereafter acquired by Company, including inventions, designs, patents (whether registered or unregistered), copyrights (whether registered or unregistered),
trademarks (whether registered or unregistered), trade secrets, domain names, confidential or proprietary technical and business information, know-how, methods, processes, drawings, specifications or other data or information and all memoranda,
notes and records with respect to any research and development, software and databases and all embodiments or fixations thereof whether in tangible or intangible form or contained on magnetic media readable by machine together with all such magnetic
media and related documentation, registrations and franchises, and 

 
all additions, improvements and accessions to, and books and records describing or used in connection with, any of the foregoing. 

“Obligations” means all loans, advances, debts, liabilities and obligations, howsoever arising, owed by
Company to Collateral Agent and the Investors of every kind and description (whether or not evidenced by any note or instrument and whether or not for the payment of money), now existing or hereafter arising under or pursuant to the terms of the
Notes and the other Transaction Documents, including, all interest, fees, charges, expenses, attorneys’ fees and costs and accountants’ fees and costs chargeable to and payable by Company hereunder and thereunder, in each case, whether
direct or indirect, absolute or contingent, due or to become due, and whether or not arising after the commencement of a proceeding under Title 11 of the United States Code (11 U.S.C. Section 101 et seq.), as amended from time to time
(including post-petition interest) and whether or not allowed or allowable as a claim in any such proceeding. Notwithstanding the foregoing, the term “Obligations” shall not include any obligations of Company under or with respect to the
Warrants or any warrants to purchase Company’s capital stock. 
 “Permitted Liens” means
(a) Liens for taxes not yet delinquent or Liens for taxes being contested in good faith and by appropriate proceedings for which adequate reserves have been established; (b) Liens in respect of property or assets imposed by law which were
incurred in the ordinary course of business, such as carriers’, warehousemen’s, materialmen’s and mechanics’ Liens and other similar Liens arising in the ordinary course of business which are not delinquent or remain payable
without penalty or which are being contested in good faith and by appropriate proceedings; (c) Liens incurred or deposits made in the ordinary course of business in connection with workers’ compensation, unemployment insurance and other
types of social security, and other Liens to secure the performance of tenders, statutory obligations, contract bids, government contracts, performance and return of money bonds and other similar obligations, incurred in the ordinary course of
business, whether pursuant to statutory requirements, common law or consensual arrangements; (d) Liens in favor of the Collateral Agent; (e) Liens upon any equipment acquired or held by Company or any of its Subsidiaries to secure the
purchase price of such equipment or indebtedness incurred solely for the purpose of financing the acquisition of such equipment, so long as such Lien extends only to the equipment financed, and any accessions, replacements, substitutions and
proceeds (including insurance proceeds) thereof or thereto; (f) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default; (g) Liens in favor of customs and revenue authorities arising as a
matter of law to secure payments of customs duties in connection with the importation of goods, (h) Liens which constitute rights of setoff of a customary nature or banker’s liens, whether arising by law or by contract; (i) Liens on
insurance proceeds in favor of insurance companies granted solely as security for financed premiums; (j) leases or subleases and licenses or sublicenses granted in the ordinary course of Company’s business; (k) leases, subleases,
licenses, sub-licenses and similar arrangements for the use of the property of the Company granted in the ordinary course of business; (l) Liens in favor of Lighthouse Capital Partners V, L.P. pursuant to the Loan and Security Agreement, dated
March 29, 2005, as amended, with Lighthouse Capital Partners V, L.P.; (m) Liens in favor of Bridge Bank, National Association (“Bridge Bank”), pursuant to that certain revolving credit line entered into December 2010 with
Bridge Bank; (n) Liens incurred in the extension, renewal or refinancing of any of the indebtedness secured by any Permitted Lien; (o) Liens in favor of financial institutions arising in connection with the Company’s deposit and
securities accounts held at such institutions; and (p) other Liens which, individually or in the aggregate, would not (i) reasonably be expected to have a material adverse effect on the Company’s business or the Liens granted to
Collateral Agent hereunder and (ii) do not exceed Two Hundred Fifty Thousand Dollars ($250,000) in the aggregate. 
 “UCC” means the Uniform Commercial Code as in effect in the State of Washington from time to time. 

  
 -2-

 All capitalized terms not otherwise defined herein shall have the respective
meanings given in the Notes. Unless otherwise defined herein, all terms defined in the UCC have the respective meanings given to those terms in the UCC. 
 2.    Grant of Security Interest.    As security for the Obligations, Company hereby pledges to Collateral Agent and grants to Collateral Agent a security
interest of first priority (except for Permitted Liens) in all right, title and interests of Company in and to the property described in Attachment 1 hereto, whether now existing or hereafter from time to time acquired (collectively, the
“Collateral”). 
 3.    General Representations and
Warranties.    Company represents and warrants to Collateral Agent and the Investors that (a) Company is the owner of the Collateral (or, in the case of after-acquired Collateral, at the time Company acquires rights in
the Collateral, will be the owner thereof) and that no other Person has (or, in the case of after-acquired Collateral, at the time Company acquires rights therein, will have) any right, title, claim or interest (by way of Lien or otherwise) in,
against or to the Collateral, other than Permitted Liens; (b) upon the filing of UCC-1 financing statements in the appropriate filing offices, Collateral Agent has (or in the case of after-acquired Collateral, at the time Company acquires
rights therein, will have) a first priority perfected security interest in the Collateral to the extent that a security interest in the Collateral can be perfected by such filing, except for Permitted Liens; (c) all Inventory has been (or, in
the case of hereafter produced Inventory, will be) produced in compliance with applicable laws, including the Fair Labor Standards Act; (d) all accounts receivable and payment intangibles are genuine and enforceable against the party obligated
to pay the same; (e) the originals of all documents evidencing all accounts receivable and payment intangibles of Company and the only original books of account and records of Company relating thereto are, and will continue to be, kept at the
address of the Company set forth in Section 9 of this Security Agreement. 

4.    Covenants Relating to Collateral.    Company hereby agrees
(a) to perform all acts that may be necessary to maintain, preserve, protect and perfect the Collateral, the Lien granted to Collateral Agent therein and the perfection and priority of such Lien, except for Permitted Liens; (b) not to use
or permit any Collateral to be used (i) in violation in any material respect of any applicable law, rule or regulation, or (ii) in violation of any policy of insurance covering the Collateral; (c) to pay promptly when due all material
taxes and other governmental charges, all material Liens and all other material charges now or hereafter imposed upon or affecting any Collateral; (d) to procure, execute and deliver from time to time any endorsements, assignments, financing
statements and other writings reasonably deemed necessary or appropriate by Collateral Agent to perfect, maintain and protect its Lien hereunder and the priority thereof and to deliver promptly upon the request of Collateral Agent all originals of
Collateral consisting of instruments; (e) if Collateral Agent gives value to enable Company to acquire rights in or the use of any Collateral, to use such value for such purpose; (f) not to surrender or lose possession of (other than to
Collateral Agent), sell, encumber, lease, rent, or otherwise dispose of or transfer any Collateral or right or interest therein, and to keep the Collateral free of all Liens except Permitted Liens; provided that Company may sell,
lease, transfer, license or otherwise dispose of any of the Collateral in the ordinary course of business consisting of (i) the sale of inventory, (ii) sales of worn-out or obsolete equipment, (iii) licenses and similar arrangements
for the use of the property of Company, and (iv) other dispositions and transfers in an amount not to exceed $250,000 in the aggregate in any fiscal year; and (g) to permit Collateral Agent and its representatives the right, at any time
during normal business hours, upon reasonable prior notice, to visit and inspect the properties of Company and its corporate, financial and operating records, and make abstracts therefrom, and to discuss Company’s affairs, finances and accounts
with its directors, officers and independent public accountants. 

  
 -3-

 5.    Authorized Action by Collateral
Agent.    Company hereby irrevocably appoints Collateral Agent as its attorney-in-fact (which appointment is coupled with an interest) and agrees that Collateral Agent may perform (but Collateral Agent shall not be obligated
to and shall incur no liability to Company or any third party for failure so to do) any act which Company is obligated by this Security Agreement to perform, and to exercise such rights and powers as Company might exercise with respect to the
Collateral, including the right to: (a) collect by legal proceedings or otherwise and endorse, receive and receipt for all dividends, interest, payments, proceeds and other sums and property now or hereafter payable on or on account of the
Collateral; (b) enter into any extension, reorganization, deposit, merger, consolidation or other agreement pertaining to, or deposit, surrender, accept, hold or apply other property in exchange for the Collateral; (c) make any compromise
or settlement, and take any action it deems advisable, with respect to the Collateral; (d) insure, process and preserve the Collateral; (e) pay any indebtedness of Company relating to the Collateral; and (f) file UCC financing
statements and execute other documents, instruments and agreements required hereunder; provided, however, that Collateral Agent shall not exercise any such powers granted pursuant to subsections (a) through (e) prior to the
occurrence of an Event of Default and shall only exercise such powers during the continuance of an Event of Default. Company agrees to reimburse Collateral Agent upon demand for any reasonable costs and expenses, including attorneys’ fees,
Collateral Agent may incur while acting as Company’s attorney-in-fact hereunder, all of which costs and expenses are included in the Obligations. It is further agreed and understood between the parties hereto that such care as Collateral Agent
gives to the safekeeping of its own property of like kind shall constitute reasonable care of the Collateral when in Collateral Agent’s possession; provided, however, that Collateral Agent shall not be required to make any
presentment, demand or protest, or give any notice and need not take any action to preserve any rights against any prior party or any other person in connection with the Obligations or with respect to the Collateral. 

6.    Default and Remedies. 

(a) Default.    Company shall be deemed in default under this Security Agreement upon the
occurrence and during the continuance of an Event of Default (as defined in the Notes). 
 (b)
Remedies.    Upon the occurrence and during the continuance of any such Event of Default, Collateral Agent shall have the rights of a secured creditor under the UCC, all rights granted by this Security Agreement and by
law, including the right to: (a) require Company to assemble the Collateral and make it available to Collateral Agent and the Investors at a place to be designated by Collateral Agent and the Investors; and (b) prior to the disposition of
the Collateral, store, process, repair or recondition it or otherwise prepare it for disposition in any manner and to the extent Collateral Agent and the Investors deem appropriate. Company hereby agrees that ten (10) days’ notice of any
intended sale or disposition of any Collateral is reasonable. In furtherance of Collateral Agent’s rights hereunder, Company hereby grants to Collateral Agent an irrevocable, non-exclusive license, exercisable without royalty or other payment
by Collateral Agent, and only in connection with the exercise of remedies hereunder, to use, license or sublicense any patent, trademark, trade name, copyright or other intellectual property in which Company now or hereafter has any right, title or
interest together with the right of access to all media in which any of the foregoing may be recorded or stored. Notwithstanding any provision of this Security Agreement, the Collateral Agent’s and the Investors’ rights and remedies under
this Security Agreement are subject to the terms and conditions of the Subordination Agreement and to the extent that any provisions of this Security Agreement are inconsistent with any of terms and conditions of the Subordination Agreement, the
terms and conditions of the Subordination Agreement shall control. 
 (c) Application of Collateral
Proceeds. The proceeds and/or avails of the Collateral, or any part thereof, and the proceeds and the avails of any remedy hereunder (as well as any other amounts of any 

  
 -4-

 
kind held by Collateral Agent at the time of, or received by Collateral Agent after, the occurrence of an Event of Default) shall be paid to and applied as follows: 

  (i)      First, to the payment of reasonable costs and expenses, including all amounts
expended to preserve the value of the Collateral, of foreclosure or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper fees, expenses, liability and advances, including reasonable legal expenses and
attorneys’ fees, incurred or made hereunder by Collateral Agent; 

 (ii)      Second, to the payment to each Investor of the amount then owing or unpaid on such
Investor’s Note, and in case such proceeds shall be insufficient to pay in full the whole amount so due, owing or unpaid upon such Note, then its Pro Rata Share of the amount remaining to be distributed (to be applied first to accrued interest
and second to outstanding principal); 
 (iii)      Third, to the payment of other amounts
then payable to each Investor under any of the Transaction Documents, and in case such proceeds shall be insufficient to pay in full the whole amount so due, owing or unpaid under such Transaction Documents, then its Pro Rata Share of the amount
remaining to be distributed; and 
 (iv)      Fourth, to the payment of the surplus, if
any, to Company, its successors and assigns, or to whomsoever may be lawfully entitled to receive the same. 

For purposes of this Security Agreement, the term “Pro Rata Share” shall mean, when calculating an
Investor’s portion of any distribution or amount, that distribution or amount (expressed as a percentage) equal to a fraction (i) the numerator of which is the original outstanding principal amount of such Investor’s Note and
(ii) the denominator of which is the original aggregate outstanding principal amount of all Notes issued under the Purchase Agreement. In the event that an Investor receives payments or distributions in excess of its Pro Rata Share, then such
Investor shall hold in trust all such excess payments or distributions for the benefit of the other Investors and shall pay such amounts held in trust to such other Investors upon demand by such Investors. 

7.    Collateral Agent. 

(a) Appointment.    The Investors hereby appoint
[                    ] as collateral agent for the Investors under this Security Agreement (in such capacity, the “Collateral
Agent”) to serve from the date hereof until the termination of the Security Agreement. 
 (b) Powers
and Duties of Collateral Agent, Indemnity by Investors. 
   (i)      Each Investor
hereby irrevocably authorizes the Collateral Agent to take such action and to exercise such powers with regard to the security interest granted herein, the rights to the Collateral and all other rights and remedies hereunder, solely as requested in
writing by a Majority in Interest of Investors in accordance with the terms hereof, together with such powers as are reasonably incidental thereto. Collateral Agent may execute any of its duties hereunder by or through agents or employees and shall
be entitled to request and act in reliance upon the advice of counsel concerning all matters pertaining to its duties hereunder and shall not be liable for any action taken or omitted to be taken by it in good faith in accordance therewith. These
powers are granted to the Collateral Agent in order empower the Collateral Agent to promote the best interests of all the Investors, taken as a whole, and not the interests any one Investor or group of Investors at the expense of others. 

  
 -5-

  (ii)      Neither the Collateral Agent nor any of its
directors, officers or employees shall be liable or responsible to any Investor or to Company for any action taken or omitted to be taken by Collateral Agent or any other such person hereunder or under any related agreement, instrument or document,
except in the case of gross negligence or willful misconduct on the part of the Collateral Agent, nor shall the Collateral Agent or any of its directors, officers or employees be liable or responsible for: (i) the validity, effectiveness,
sufficiency, enforceability or enforcement of the Notes, this Security Agreement or any instrument or document delivered hereunder or relating hereto; (ii) the title of Company to any of the Collateral or the freedom of any of the Collateral
from any prior or other liens or security interests; (iii) the determination, verification or enforcement of Company’s compliance with any of the terms and conditions of this Security Agreement; (iv) the failure by Company to deliver
any instrument or document required to be delivered pursuant to the terms hereof; or (v) the receipt, disbursement, waiver, extension or other handling of payments or proceeds made or received with respect to the collateral, the servicing of
the Collateral or the enforcement or the collection of any amounts owing with respect to the Collateral. 

(iii)      In the case of this Security Agreement and the transactions contemplated hereby and any related
document relating to any of the Collateral, Company agrees to pay to the Collateral Agent, on demand, all fees and expenses incurred in connection with the operation and enforcement of this Security Agreement, the Notes or any related agreement to
the extent that such fees or expenses have not been paid by Company, except that if the Company has not paid such fees to Collateral Agent, then each of the Investors shall pay its Pro Rata Share of such fees and expenses. In the case of this
Security Agreement and each instrument and document relating to any of the Collateral, the Company hereby agrees to hold the Collateral Agent harmless, and to indemnify the Collateral Agent from and against any and all loss, damage, expense or
liability which may be incurred by the Collateral Agent under this Security Agreement and the transactions contemplated hereby and any related agreement or other instrument or document, as the case may be, unless such liability shall be caused by
the willful misconduct or gross negligence of the Collateral Agent, except if the Company has not paid such loss, damage, expense or liability to the Collateral Agent, then each of the Investors shall pay its Pro Rata Share of such loss, damage,
expense or liability. Notwithstanding the foregoing, in no event will the aggregate obligations of any Investor under this Section 7(b)(iii) exceed the principal amount of the Note held by the Investor. 

8.    Investors’ Rights; Company Waivers. 

(a)  Any Investor’s acceptance of partial or delinquent payment from Company under any Note or hereunder,
or an Investor’s or the Collateral Agent’s failure to exercise any right hereunder, or the partial exercise of any such right, shall not constitute a waiver of any obligation of Company hereunder, or any right of any of the Investors
hereunder, and shall not affect in any way the right to require full performance at any time thereafter. 

(b)  Company waives, to the fullest extent permitted by law, (i) any right of redemption with respect to
the Collateral, whether before or after sale hereunder, and all rights, if any, of marshaling of the Collateral or other collateral or security for the Obligations; (ii) any right to require the Collateral Agent or an Investor (A) to
proceed against any person or entity, (B) to exhaust any other collateral or security for any of the Obligations, or (C) to pursue any remedy in the Collateral Agent or an Investor’s power. 

9.    Miscellaneous. 

(a)  Notices.    Except as otherwise provided herein, all notices, requests,
demands, consents, instructions or other communications to or upon Company or Collateral Agent under this Security Agreement 

  
 -6-

 
shall be in writing and faxed, mailed, delivered or transmitted via electronic mail to each party to the facsimile number, address or electronic mail address set forth below (or to such other
facsimile number, address or electronic mail address as the recipient of any notice shall have notified the other in writing). All such notices and communications shall be effective (a) when sent by Federal Express or other overnight service of
recognized standing, on the business day following the deposit with such service; (b) when mailed, by registered or certified mail, first class postage prepaid and addressed as aforesaid through the United States Postal Service, upon receipt;
(c) when delivered by hand, upon delivery; and (d) one business day after being faxed or transmitted via electronic mail (in either case, with receipt of appropriate confirmation). 

Collateral Agent: 
 [                                ]

[                      
          ] 

[                      
          ] 
 Attention:
[                                ] 

Telephone:
[                                ] 

Email:
[                                ] 

with a copy to: 
 [                                ]

[                      
          ] 

[                      
          ] 
 Telephone:
[                                ] 

Facsimile:
[                                ] 

Email:
[                                ] 

Company: 
 Fluidigm Corporation 
 Attn: Corporate Secretary 

7000 Shoreline Court, Suite 100 
 South San Francisco, CA 94080 
 Telephone: (650) 266-6000 

Facsimile: (650) 871-7152 
 Email:
[                                ] 

with a copy to: 
 Robert F. Kornegay 
 Wilson Sonsini Goodrich & Rosati 

650 Page Mill Road 
 Palo Alto, CA 94304 
 Telephone: (650) 493-9300 

Facsimile: (650) 493-6811 
 Email: rkornegay@wsgr.com 
 (b) Termination of Security
Interest.    Upon the payment in full of all Obligations, the security interest granted herein shall terminate and all rights to the Collateral shall revert to Company. Upon such termination Collateral Agent hereby authorizes
Company to file any UCC termination statements 

  
 -7-

 
necessary to effect such termination and Collateral Agent will execute and deliver to Company any additional documents or instruments as Company shall reasonably request to evidence such
termination. 
 (c) Nonwaiver.    No failure or delay on Collateral Agent’s part
in exercising any right hereunder shall operate as a waiver thereof or of any other right nor shall any single or partial exercise of any such right preclude any other further exercise thereof or of any other right. 

(d) Amendments and Waivers.    This Security Agreement may not be amended or modified, nor may
any of its terms be waived, except by written instruments signed by Company, Collateral Agent and a Majority in Interest of Investors; provided, however, that no such amendment, waiver or consent shall adversely affect the rights or
increase obligations of an Investor under this Agreement without a corresponding equivalent change in the rights and obligations of all other Investors, without the prior written consent of each such adversely affected Investor. Each waiver or
consent under any provision hereof shall be effective only in the specific instances for the purpose for which given. 
 (e) Assignments.    This Security Agreement shall be binding upon and inure to the benefit of Collateral Agent and Company and their respective successors and assigns;
provided, however, that Company may not sell, assign or delegate rights and obligations hereunder without the prior written consent of Collateral Agent. 

(f) Cumulative Rights, etc.    The rights, powers and remedies of Collateral Agent under this
Security Agreement shall be in addition to all rights, powers and remedies given to Collateral Agent by virtue of any applicable law, rule or regulation of any governmental authority, any Transaction Document or any other agreement, all of which
rights, powers, and remedies shall be cumulative and may be exercised successively or concurrently without impairing Collateral Agent’s rights hereunder. Company waives any right to require Collateral Agent to proceed against any person or
entity or to exhaust any Collateral or to pursue any remedy in Collateral Agent’s power. 
 (g) Payments
Free of Taxes, Etc.    All payments made by Company under the Transaction Documents shall be made by Company free and clear of and without deduction for any and all present and future taxes, levies, charges, deductions and
withholdings. In addition, Company shall pay upon demand any stamp or other taxes, levies or charges of any jurisdiction with respect to the execution, delivery, registration, performance and enforcement of this Security Agreement. Upon request by
Collateral Agent, Company shall furnish evidence satisfactory to Collateral Agent that all requisite authorizations and approvals by, and notices to and filings with, governmental authorities and regulatory bodies have been obtained and made and
that all requisite taxes, levies and charges have been paid. 
 (h) Partial
Invalidity.    If at any time any provision of this Security Agreement is or becomes illegal, invalid or unenforceable in any respect under the law or any jurisdiction, neither the legality, validity or enforceability of the
remaining provisions of this Security Agreement nor the legality, validity or enforceability of such provision under the law of any other jurisdiction shall in any way be affected or impaired thereby. 

(i) Construction.    Each of this Security Agreement and the other Transaction Documents is
the result of negotiations among, and has been reviewed by, Company, Investors, Collateral Agent and their respective counsel. Accordingly, this Security Agreement and the other Transaction Documents shall be deemed to be the product of all parties
hereto, and no ambiguity shall be construed in favor of or against Company, Investors or Collateral Agent. 

  
 -8-

 (j) Entire Agreement.    This Security Agreement
taken together with the other Transaction Documents constitute and contain the entire agreement of Company, Investors and Collateral Agent and supersede any and all prior agreements, negotiations, correspondence, understandings and communications
among the parties, whether written or oral, respecting the subject matter hereof. 
 (k) Other Interpretive
Provisions.    References in this Security Agreement and each of the other Transaction Documents to any document, instrument or agreement (a) includes all exhibits, schedules and other attachments thereto,
(b) includes all documents, instruments or agreements issued or executed in replacement thereof, and (c) means such document, instrument or agreement, or replacement or predecessor thereto, as amended, modified and supplemented from time
to time and in effect at any given time. The words “hereof,” “herein” and “hereunder” and words of similar import when used in this Security Agreement or any other Transaction Document refer to this Security Agreement
or such other Transaction Document, as the case may be, as a whole and not to any particular provision of this Security Agreement or such other Transaction Document, as the case may be. The words “include” and “including” and
words of similar import when used in this Security Agreement or any other Transaction Document shall not be construed to be limiting or exclusive. 
 (l) Governing Law.    This Security Agreement shall be governed by and construed in accordance with the laws of the State of California without reference to conflicts of law
rules (except to the extent governed by the UCC). 
 (m) Counterparts.    This
Security Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall be deemed to constitute one instrument. 
 [The remainder of this page is intentionally left blank] 

  
 -9-

 IN WITNESS WHEREOF, Company has caused this Security Agreement to be
executed as of the day and year first above written. 
  

	
	FLUIDIGM CORPORATION
	
	  

	 Gajus V. Worthington, President & CEO

 [Signature Page to Security Agreement] 

 IN WITNESS WHEREOF, Company has caused this Security Agreement to be
executed as of the day and year first above written. 
  

	
	AGREED:
	
	[                        ],
	As Collateral Agent

  

			
	 By:
	 	  

			
		
	 Name:
	 	  

			
		
	 Title:
	 	  

[Signature Page to Security Agreement] 

 IN WITNESS WHEREOF, Company has caused this Security Agreement to be
executed as of the day and year first above written. 
  

									
	 INVESTOR:
	 		 	  

					
		 		 	 By:
	 	  
	 	
					
		 		 	 Name:
	 	  
	 	
					
		 		 	 Title:
	 	  
	 	

 [Signature Page to Security Agreement] 

 ATTACHMENT 1 
 TO SECURITY AGREEMENT 
 All right, title, interest, claims and demands of
Company in and to the following property: 
 (i)      All Accounts; 

(ii)     All Chattel Paper; 
 (iii)    All Deposit Accounts and cash; 

(iv)     All Documents; 
 (v)      All Equipment; 

(vi)     All General Intangibles (other than Intellectual Property); 

(vii)    All Goods; 
 (viii)   All Instruments; 
 (ix)     All
Inventory; 
 (x)      All Investment Property; 

(xi)     All Letter-of-Credit Rights 
 (xii)    To the extent not otherwise included, all Proceeds and products of any and all of the foregoing, and all accessions to, substitutions and replacements for, and rents and
profits of each of the foregoing. 
 The term “Intellectual Property” means all intellectual and similar
property of every kind and nature now owned or hereafter acquired by Company, including inventions, designs, patents (whether registered or unregistered), copyrights (whether registered or unregistered), trademarks (whether registered or
unregistered), trade secrets, domain names, confidential or proprietary technical and business information, know-how, methods, processes, drawings, specifications or other data or information and all memoranda, notes and records with respect to any
research and development, software and databases and all embodiments or fixations thereof whether in tangible or intangible form or contained on magnetic media readable by machine together with all such magnetic media and related documentation,
registrations and franchises, and all additions, improvements and accessions to, and books and records describing or used in connection with, any of the foregoing. 
 All capitalized terms used in this Attachment 1 and not otherwise defined herein, shall have the respective meanings given to such terms in the Uniform Commercial Code of the State of California as
in effect from time to time. 

 Exhibit D 
 FORM OF SUBORDINATION AGREEMENT 

 SUBORDINATION AGREEMENT 

(SECURED DEBT) 
 {PRIVATE} 
 This SUBORDINATION AGREEMENT (secured debt) (this
“Agreement”), dated as of January     , 2011, is between, on the one hand, each undersigned holder (each a “Holder” and collectively the “Holders”) of Subordinated Secured Promissory
Notes issued pursuant to that certain Note and Warrant Purchase Agreement dated January     , 2011 (each a “Note” and collectively the “Notes”) issued by Fluidigm Corporation (“Company”),
and, on the other hand, (a) Lighthouse Capital Partners V, L.P., a Delaware limited partnership (“LCP”), lender to Company under that certain Loan and Security Agreement, dated March 29, 2005, as amended (all obligations of
payment and performance due or to become due thereunder, as the same may be amended from time to time, are the “LCP Obligations”) and (b) Bridge Bank, National Association (“BB,” BB together with LCP are the
“Lenders” and each individually is a “Lender”), lender to Company under that certain Business Financing Agreement, dated December 13, 2010 (all obligations of payment and performance due or to become due thereunder, as the
same may be amended from time to time, are the “BB Obligations”), with references to the following: 

WHEREAS, the Notes are secured by the property of the Company, and are to be subordinated to the LCP Obligations and the
BB Obligations (the LCP Obligations and the BB Obligations are collectively the “Debt Obligations”); 
 NOW,
THEREFORE, in consideration of the mutual promises herein contained, the parties hereby agree as follows: 

1.    Subordination.  Regardless of (i) any agreement of any Holder or Lender
with Company, (ii) the time, place, manner or order of attachment, perfection, or the filing of UCC-1 filings or other documents, or (iii) the giving or failure to give notice, each Holder does hereby subordinate payment by Company on its
Notes to the full and final payment of the Debt Obligations. So long as any Debt Obligations remain outstanding, each Holder agrees (a) that all payments, any collateral security now or hereafter obtained from any source as collateral or
security for Company’s obligations to Holders (“Holder Collateral”), and any proceeds thereof received by Holders, shall be held by them in trust for Lenders for the payment of the Debt Obligations, and turned over to the
Lenders in kind upon receipt of notice from a Lender, and (b) to not foreclose upon Holder Collateral, if any, without Lenders’ prior written consent. Any lien of Holders in any Holder Collateral is expressly subordinated to the lien of
the Lenders therein. Nothing in this Agreement prohibits the Holders from electing to convert or the Company from converting the Notes into equity securities of the Company regardless of whether the Debt Obligations have been fully paid. 

2.      Acknowledgment of Lenders’ Rights and Remedies.  The Lenders
have entered into that certain Intercreditor Agreement dated as of December 13, 2010 (the “Intercreditor Agreement”), which as between the Lenders provides, among other things, for lien and payment priorities between the Lenders and
other matters respecting Holder Collateral. Nothing herein contained shall alter or impair the rights of either Lender under the Intercreditor Agreement, and nothing herein shall give any Holder any rights under or with respect to the
Intercreditor Agreement. As between the Lenders, the Lenders shall conduct matters respecting Holder Collateral, including disposition of proceeds held in trust turned over by a Holder pursuant to Section 1 hereof, pursuant to the terms of
the Intercreditor Agreement. Without amending any term of the Intercreditor Agreement or making any of them parties thereto or granting them any rights thereunder, and using the Intercreditor Agreement solely as a reference, each Holder and the
Collateral Agent, as defined in the Security Agreement dated as of January     , 2011 by and between Collateral Agent and Company, hereby incorporates each of the waivers, understandings and obligations

 
of LCP in favor of BB contained in such Intercreditor Agreement as if fully set forth herein and adopts each of them as its own in favor of Lenders. 

3.        Bankruptcy.  Each Holder agrees that upon any
distribution of assets or readjustment of indebtedness of Company, whether by liquidation, bankruptcy, assignment for the benefit of creditors, or otherwise, the Lenders shall receive payment in full on the Debt Obligations before Holder receives
payment of any amounts due under the Notes, and any amounts that would otherwise be due to Holder shall be paid to the Lenders. In furtherance thereof, each Holder authorizes the Lenders to make and vote (without a Lender being obligated to make or
vote) any and all proofs of claim respecting the Notes in any such proceeding and to receive and collect all dividends or other payments thereupon; provided that the Lenders will pay over to Holders a pro rata distribution of amounts received by the
Lenders in excess of that necessary for the full and final satisfaction of the Debt Obligations; provided further, that under no circumstances will the Holders or the Lenders vote the claims in a manner which (i) modifies any rights of lien
priority of a party hereto, (ii) challenges the rights, remedies or validity of a Lender’s loan or liens, and (iii) causes any change in the terms or maturity of the Debt Obligations absent the prior written consent of the affected
Lender, except as, as between the Lenders only and not Holders, as provided in the Intercreditor Agreement. Holders agree to execute such instruments of assignment and other documents as may be necessary to enforce such claims and collect such
dividends or to otherwise carry out the intent and purpose hereof. 

4.        Representations.  Each party hereto warrants and
represents to the others that it has full power and authority to enter hereinto and to perform all obligations hereunder, that this Agreement is valid, binding and enforceable in accordance with its terms and that execution and performance hereof
does not violate any agreement with any other person or entity. Each Holder represents and warrants that it (i) is the owner of the Notes, free and clear of the claims of any others, (ii) has not heretofore subordinated or assigned the
Notes or its interest in Holder Collateral to any entity, (iii) will not transfer any Notes to any entity other than one which agrees to be bound hereby, and (iv) waives any rights to claim that the enforceability of this Agreement may be
affected by any subsequent modification, release, extension, or change in the Debt Obligations. 

5.        No Third Party Beneficiaries.  Company has no rights
hereunder. This Agreement is made only for the benefit of Holders and the Lenders and their respective successors and assigns, and may not be relied upon by any other third party, including Company or any successor thereto or any judgment lien
creditor thereof. Nothing herein shall constitute a commitment or agreement by LCP, BB or Holders to provide funds to Company. 

[REMAINDER OF PAGE LEFT BLANK INTENTIONALLY] 

6.        Miscellaneous.  This Agreement: (i) may only be
amended by a writing signed by LCP, BB and the affected Holder; (ii) contains the entire agreement between Holders and the Lenders with respect to its subject matter, and all prior negotiations, documents and discussions are superseded hereby;
(iii) shall be governed by the laws of the state of California; (iv) may be executed in counterparts delivered by telefacsimile, all of which, when taken together, shall constitute one and the same original document; (v) may be
attached to a Form UCC-1 and filed in the public records of any jurisdiction; and (vi) shall terminate upon the full, final and indefeasible payment and performance by Company to the Lenders of all Debt Obligations. 

IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first above written. 

LIGHTHOUSE CAPITAL PARTNERS V, L.P. 

By: LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner 

 

					
	 By:
	 	  
	 	
		 	       Thomas Conneely
	 	
		 	       Vice President
	 	
	
	BRIDGE BANK, NATIONAL ASSOCIATION
			
	 By:
	 	  
	 	
			
	 Name:
	 	  
	 	
			
	 Title:
	 	  
	 	

 Company hereby acknowledges and consents to the Agreement, promises to take all such action
as may be necessary to fulfill its essential intent and purpose, agrees that failure to do so shall be an Event of Default under the Debt Obligations, and acknowledges that in the transactions referenced herein it has been advised to seek, and has
selected, counsel of its own choosing. 
  

			
	FLUIDIGM CORPORATION
		
	 By:
	 	  

		
	 Name:
	 	 Gajus V. Worthington

		
	 Title:
	 	 President, Chief Executive Officer

[Signature Page to Subordination Agreement] 

  

									
	HOLDER:	 		 	  

					
		 		 	 By:
	 	  
	 	
					
		 		 	 Name:
	 	  
	 	
					
		 		 	 Title:
	 	  
	 	

 [Signature Page to Subordination Agreement] 

 Exhibit E 
 SIXTH AMENDED AND RESTATED CERTIFICATE OF INCORPORATION 
 OF FLUIDIGM
CORPORATION 

 SIXTH AMENDED AND RESTATED 

CERTIFICATE OF INCORPORATION OF 
 FLUIDIGM CORPORATION 
 Fluidigm Corporation, a corporation organized and
existing under the laws of the State of Delaware (the “Corporation”), certifies that: 

A.      The name of the corporation is Fluidigm Corporation. The original Certificate of Incorporation of
the Corporation was filed with the Secretary of State of the State of Delaware on March 29, 2007. 

B.      This Sixth Amended and Restated Certificate of Incorporation was duly adopted in accordance with
Sections 242 and 245 of the General Corporation Law of the State of Delaware and restates, integrates and further amends the provisions of the Corporation’s Fifth Amended and Restated Certificate of Incorporation. 

C.      The text of the Fifth Amended and Restated Certificate of Incorporation is amended and restated to
read as set forth in EXHIBIT A attached hereto. 
 IN WITNESS WHEREOF, Fluidigm Corporation has caused this Sixth Amended and
Restated Certificate of Incorporation to be signed by Gajus V. Worthington, a duly authorized officer of the Corporation, on
                     , 20    . 

 

	
	  

	 Gajus V. Worthington,

	 President and Chief Executive Officer

 EXHIBIT A 

ARTICLE I 
 The
name of the corporation is Fluidigm Corporation (the “Corporation”). 
 ARTICLE II 

The purpose of the Corporation is to engage in any lawful act or activity for which a corporation may be organized under the General
Corporation Law of the State of Delaware. 
 ARTICLE III 

The address of the Corporation’s registered office in the State of Delaware is Corporation Trust Center, 1209 Orange Street,
Wilmington, New Castle County, Delaware 19801. The name of its registered agent at such address is The Corporation Trust Company. 
 ARTICLE IV 
 1.    Classes of Stock. The total number
of shares of stock that the Corporation shall have authority to issue is 51,199,572, consisting of 31,704,200 shares of Common Stock, $0.0035 par value per share (“Common Stock”) and 19,495,372 shares of Preferred Stock, $0.0035 par
value per share (“Preferred Stock”). The Preferred shall be divided into series. The first series shall consist of 657,132 shares and shall be designated Series A Preferred Stock (“Series A Preferred
Stock”). The second series shall consist of 1,835,354 shares and shall be designated Series B Preferred Stock (“Series B Preferred Stock”). The third series shall consist of 4,632,898 shares and shall be
designated Series C Preferred Stock (“Series C Preferred Stock”). The fourth series shall consist of 3,782,690 shares and shall be designated Series D Preferred Stock (“Series D Preferred
Stock”). The fifth series shall consist of 106,122 shares and shall be designated Series D-1 Preferred Stock (“Series D-1 Preferred Stock”). The sixth series shall consist of 7,802,775 shares and shall be
designated Series E Preferred Stock (“Series E Preferred Stock”). The eighth series shall consist of 678,401 shares and shall be designated Series E-1 Preferred Stock (“Series E-1 Preferred
Stock”). 
 The terms and provisions of the Common Stock and Preferred Stock are as follows: 

2.     Definitions. For purposes of this Article IV, the following definitions shall apply: 

(a)    “Conversion Price” shall mean $3.85 per share for the Series A Preferred Stock, $6.23
per share for the Series B Preferred Stock, $9.03 per share for the Series C Preferred Stock, $9.80 per share for the Series D Preferred Stock, $7.00 per share for the Series D-1 Preferred Stock, $10.77 for the Series E
Preferred Stock, and $7.00 per share for the Series E-1 Preferred Stock (each subject to adjustment from time to time as set forth elsewhere herein). 

 (b)    “Convertible Securities” shall mean any
evidences of indebtedness, shares or other securities (other than shares of Common Stock) convertible into or exchangeable for Common Stock. 
 (c)    “Corporation” shall mean Fluidigm Corporation. 
 (d)    “Dividend Rate” shall mean an annual rate of $0.385 per share for the Series A Preferred Stock, an annual rate of $0.63 for the Series B Preferred
Stock, an annual rate of $0.91 per share for the Series C Preferred Stock, an annual rate of $1.05 per share for the Series D Preferred Stock, an annual rate of $0.75 per share for the Series D-1 Preferred Stock, an annual rate of
$1.505 per share for the Series E Preferred Stock, and an annual rate of $0.753 per share for the Series E-1 Preferred Stock (each subject to adjustment from time to time as set forth elsewhere herein). 

(e)    “Liquidation Preference” shall mean $3.85 per share for the Series A Preferred Stock,
$6.23 per share for the Series B Preferred Stock, $9.03 per share for the Series C Preferred Stock, $9.80 per share for the Series D Preferred Stock, $7.00 per share for the Series D-1 Preferred Stock, $14.00 for the
Series E Preferred Stock, and $7.00 per share for the Series E-1 Preferred Stock (each subject to adjustment from time to time as set forth elsewhere herein). 
 (f)    “Options” shall mean rights, options or warrants to subscribe for, purchase or otherwise acquire Common Stock or Convertible Securities. 

(g)    “Original Issue Price” shall mean $3.85 per share for the Series A Preferred Stock,
$6.23 per share for the Series B Preferred Stock, $9.03 per share for the Series C Preferred Stock, $9.80 per share for the Series D Preferred Stock, $7.00 per share for the Series D-1 Preferred Stock, $14.00 for the
Series E Preferred Stock, and $7.00 per share for the Series E-1 Preferred Stock (each subject to adjustment from time to time as set forth elsewhere herein). 
 (h)    “Preferred Stock” shall mean the Series A Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock, the Series D
Preferred Stock, the Series D-1 Preferred Stock, the Series E Preferred Stock, and Series E-1 Preferred Stock. 

3.    Dividends. 
 (a)    Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and Series E-1 Preferred Stock. The holders of outstanding shares of
Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and Series E-1 Preferred Stock shall be entitled to receive dividends, when and as declared by the Board of Directors, out of any assets at the time
legally available therefor, at the Dividend Rates specified for such shares of Preferred Stock, payable in preference and priority to any declaration or payment of any distribution on Series A Preferred Stock, Series B Preferred Stock,
Series C Preferred Stock or Common Stock of the Corporation other than a dividend payable solely in Common Stock. No distributions shall be made with respect to the Series A Preferred Stock, Series B Preferred Stock, Series C
Preferred Stock or Common Stock during any fiscal year of the Corporation, other than dividends on the Common Stock payable solely in Common Stock, until all dividends at the applicable Dividend Rate on the Series E Preferred Stock,
Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock have been declared and paid or set apart for payment to the holders of Series E Preferred Stock, Series E-1 Preferred Stock, Series D
Preferred Stock and Series D-1 Preferred Stock. Payment of 

  
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any dividends to the holders of the Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock shall be on a pro
rata, pari passu basis in proportion to the Dividend Rates for the Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock, as applicable. The right to
receive dividends on shares of Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock shall not be cumulative, and no right to such dividends shall accrue to holders of
Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock by reason of the fact that dividends on said shares are not declared or paid in any year. 

(b)    Series C Preferred Stock. The holders of outstanding shares of Series C Preferred Stock
shall be entitled to receive dividends, when and as declared by the Board of Directors, out of any assets at the time legally available therefor, at the Dividend Rate specified for such shares of Preferred Stock payable in preference and priority to
any declaration or payment of any distribution on Series A Preferred Stock, Series B Preferred Stock or Common Stock of the Corporation other than a dividend payable solely in Common Stock. No distributions shall be made with respect to
the Series A Preferred Stock, Series B Preferred Stock or Common Stock during any fiscal year of the Corporation, other than dividends on the Common Stock payable solely in Common Stock, until all dividends at the applicable Dividend Rate
on the Series C Preferred Stock have been declared and paid or set apart for payment to the holders of Series C Preferred Stock. The right to receive dividends on shares of Series C Preferred Stock shall not be cumulative, and no
right to such dividends shall accrue to holders of Series C Preferred Stock by reason of the fact that dividends on said shares are not declared or paid in any year. 
 (c)    Series A Preferred Stock and Series B Preferred Stock. The holders of outstanding shares of Series A Preferred Stock and the holders of outstanding shares
of Series B Preferred Stock shall be entitled to receive dividends, when and as declared by the Board of Directors, out of any assets at the time legally available therefor, at the Dividend Rates specified for such shares of Preferred Stock
payable in preference and priority to any declaration or payment of any distribution on Common Stock of the Corporation other than a dividend payable solely in Common Stock. No distributions shall be made with respect to the Common Stock, other than
dividends payable solely in Common Stock, until all dividends at the applicable Dividend Rate on the Preferred Stock have been declared and paid or set apart for payment to the Preferred Stock holders. Payment of any dividends to the holders of the
Series A Preferred Stock and Series B Preferred Stock shall be on a pro rata, pari passu basis in proportion to the Dividend Rates for the Series A Preferred Stock and Series B Preferred Stock, as applicable. The
right to receive dividends on shares of Series A Preferred Stock and Series B Preferred Stock shall not be cumulative, and no right to such dividends shall accrue to holders of Series A Preferred Stock or Series B Preferred Stock
by reason of the fact that dividends on said shares are not declared or paid in any year. 

(d)    Distribution. For purposes of this Section 3, unless the context otherwise requires, a
“distribution” shall mean the transfer of cash or other property without consideration whether by way of dividend or otherwise, payable other than in Common Stock, or the purchase or redemption of shares of the Corporation other
than (i) repurchase of shares of Common Stock issued to or held by employees, consultants, officers and directors of the Corporation or its subsidiaries upon termination of their employment or services pursuant to agreements providing for the
right of said repurchase and at the original purchase price paid by such employees, consultants, officers and 

  
 -3-

 
directors; and (ii) repurchase of Common Stock issued to or held by employees, officers, directors or consultants of the Corporation or its subsidiaries pursuant to rights of first refusal
contained in agreements providing for such rights, provided that such repurchase is unanimously approved by the Board of Directors; and (iii) any other repurchase or redemption of capital stock of the corporation unanimously approved by the
Board of Directors and approved by the holders of the majority of the Common Stock and the holders of more than two-thirds
( 2/3) of the outstanding shares of the Preferred
Stock, voting as separate classes. 
 (e)    Common Stock. Dividends may be paid on the
Common Stock as and when declared by the Board of Directors, subject to the prior dividend rights of the Preferred Stock and Sections 7, 8, 9, and 10 below. 
 (f)    Non-Cash Distributions. Whenever a distribution provided for in this Section 3 shall be payable in property other than cash, the value of such distribution shall be
deemed to be the fair market value of such property as determined in good faith by the Board of Directors. 

(g)    Consent to Certain Repurchases. If Sections 502 and 503 of the California Corporations Code are
determined to apply to the Corporation, as authorized by Section 402.5(c) of the California Corporations Code, Sections 502 and 503 of the California Corporations Code shall not apply with respect to payments made by the Corporation in
connection with (i) repurchase of shares of Common Stock issued to or held by employees, consultants, officers and directors of the Corporation or its subsidiaries upon termination of their employment or services pursuant to agreements
providing for the right of said repurchase and at the original purchase price paid by such employees, consultants, officers and directors, and (ii) repurchase of Common Stock issued to or held by employees, officers, directors and consultants
of the Corporation or its subsidiaries pursuant to rights of first refusal contained in agreements providing for such rights, provided that such repurchase is unanimously approved by the Board of Directors, and (iii) any other repurchase or
redemption of Common Stock unanimously approved by the Board of Directors and approved by the holders of more than two-thirds
( 2/3) of the outstanding shares of Preferred Stock
voting together as a single class. 
 4.    Liquidation Rights. 

In the event of any liquidation, dissolution or winding up of the Corporation, either voluntary or involuntary, distribution of the
assets of the Corporation legally available for distribution to the Corporation’s stockholders shall be made in the following manner: 
 (a)    Series E and Series E-1 Liquidation Preference. The holders of the Series E Preferred Stock and Series E-1 Preferred Stock shall be entitled to
receive, prior and in preference to any distribution of any of the assets of the Corporation to the holders of the Common Stock, the Series A Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock, the
Series D Preferred Stock or the Series D-1 Preferred Stock, by reason of their ownership of such stock, an amount per share for each share of Series E Preferred Stock or Series E-1 Preferred Stock, as applicable, held by them
equal to the sum of (i) the Liquidation Preference for such share and (ii) all declared and unpaid dividends on such share of Series E Preferred Stock or Series E-1 Preferred Stock. If the assets of the Corporation legally
available for distribution to the holders of the Series E Preferred Stock and Series E-1 Preferred Stock are insufficient to permit the payment to such holders 

  
 -4-

 
of the full amounts specified in this Section 4(a), then the entire assets of the Corporation legally available for distribution shall be distributed with equal priority and pro
rata among the holders of the Series E Preferred Stock and Series E-1 Preferred Stock in proportion to the full amounts they would otherwise be entitled to receive pursuant to this Section 4(a). 

(b)    Series D and Series D-1 Liquidation Preference. After payment to the holders of
Series E Preferred Stock and Series E-1 Preferred Stock of the full amounts specified in Section 4(a) above, the holders of the Series D Preferred Stock and Series D-1 Preferred Stock shall be entitled to receive, prior and
in preference to any distribution of any of the assets of the Corporation to the holders of the Common Stock, the Series A Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock by reason of their ownership of
such stock, an amount per share for each share of Series D Preferred Stock or Series D-1 Preferred Stock, as applicable, held by them equal to the sum of (i) the Liquidation Preference for such share and (ii) all declared and
unpaid dividends on such share of Series D Preferred Stock or Series D-1 Preferred Stock. If the remaining assets of the Corporation legally available for distribution to the holders of Series D Preferred Stock and Series D-1
Preferred Stock are insufficient to permit the payment to such holders of the full amounts specified in this Section 4(b), then the entire remaining assets of the Corporation legally available for distribution shall be distributed with equal
priority and pro rata among the holders of the Series D Preferred Stock and Series D-1 Preferred Stock in proportion to the full amounts they would otherwise be entitled to receive pursuant to this Section 4(b).

 (c)    Series C Liquidation Preference. After payment to the holders of Series E
Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock and Series D-1 Preferred Stock of the full amounts specified in Sections 4(a) and 4(b) above, the holders of the Series C Preferred Stock shall be
entitled to receive, prior and in preference to any distribution of any of the assets of the Corporation to the holders of the Common Stock, the Series A Preferred Stock or the Series B Preferred Stock by reason of their ownership of such
stock, an amount per share for each share of Series C Preferred Stock held by them equal to the sum of (i) the Liquidation Preference for such share and (ii) all declared and unpaid dividends on such share of Series C Preferred
Stock. If the remaining assets of the Corporation legally available for distribution to the holders of the Series C Preferred Stock are insufficient to permit the payment to such holders of the full amounts specified in this Section 4(c),
then the entire remaining assets of the Corporation legally available for distribution shall be distributed with equal priority and pro rata among the holders of the Series C Preferred Stock in proportion to the full amounts they
would otherwise be entitled to receive pursuant to this Section 4(c). 
 (d)    Series B
Liquidation Preference. After payment to the holders of Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock, Series D-1 Preferred Stock and Series C Preferred Stock of the full amounts
specified in Sections 4(a), 4(b) and 4(c) above, the holders of the Series B Preferred Stock shall be entitled to receive, prior and in preference to any distribution of any of the remaining assets of the Corporation to the holders of the
Common Stock or Series A Preferred Stock by reason of their ownership of such stock, an amount per share for each share of Series B Preferred Stock held by them equal to the sum of (i) the Liquidation Preference for such share and
(ii) all declared and unpaid dividends on such share of Series B Preferred Stock. If the remaining assets of the Corporation legally available for distribution to the holders of the Series B Preferred Stock are insufficient to permit
the payment to such holders of the full amounts specified in this Section 4(d), then the entire remaining assets of the Corporation legally available for 

  
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distribution shall be distributed with equal priority and pro rata among the holders of the Series B Preferred Stock in proportion to the full amounts they would otherwise be
entitled to receive pursuant to this Section 4(d). 
 (e)    Series A Liquidation
Preference. After payment to the holders of Series E Preferred Stock, Series E-1 Preferred Stock, Series D Preferred Stock, Series D-1 Preferred Stock, Series C Preferred Stock and Series B Preferred Stock of the
full amounts specified in Sections 4(a), 4(b), 4(c) and 4(d) above, the holders of the Series A Preferred Stock shall be entitled to receive, prior and in preference to any distribution of any of the remaining assets of the
Corporation to the holders of the Common Stock by reason of their ownership of such stock, an amount per share for each share of Series A Preferred Stock held by them equal to the sum of (i) the Liquidation Preference for such share and
(ii) all declared and unpaid dividends on such share of Series A Preferred Stock. If the remaining assets of the Corporation legally available for distribution to the holders of the Series A Preferred Stock are insufficient to permit
the payment to such holders of the full amounts specified in this Section 4(e), then the entire remaining assets of the Corporation legally available for distribution shall be distributed with equal priority and pro rata among the
holders of the Series A Preferred Stock in proportion to the full amounts they would otherwise be entitled to receive pursuant to this Section 4(e). 
 (f)    Remaining Assets. After the payment to the holders of Preferred Stock of the full amounts specified in Sections 4(a), 4(b), 4(c), 4(d) and 4(e) above, the entire
remaining assets of the Corporation legally available for distribution shall be distributed pro rata to holders of the Common Stock of the Corporation in proportion to the number of shares of Common Stock held by them. 

(g)    Shares Not Treated as Both Preferred Stock and Common Stock in Any Distribution. Shares of Preferred
Stock shall not be entitled to be converted into shares of Common Stock in order to participate in any distribution, or series of distributions, as shares of Common Stock, without first foregoing participation in the distribution, or series of
distributions, as shares of Preferred Stock. 
 (h)    Reorganization. For purposes of this
Section 4, a liquidation, dissolution or winding up of the Corporation shall be deemed to be occasioned by, or to include, (i) the acquisition of the Corporation by another entity by means of any transaction or series of related
transactions (including, without limitation, any stock acquisition, reorganization, merger or consolidation but excluding any merger effected exclusively for the purpose of changing the domicile of the Corporation) other than a transaction or series
of transactions in which the holders of the voting securities of the Corporation outstanding immediately prior to such transaction or series of transactions continue to retain (either by such voting securities remaining outstanding or by such voting
securities being converted into voting securities of the surviving entity), as a result of shares in the Corporation held by such holders prior to such transaction, at least fifty percent (50%) of the total voting power represented by the
voting securities of the Corporation or such surviving entity outstanding immediately after such transaction or series of transactions; or (ii) a sale, transfer, lease or other conveyance of all or substantially all of the assets of the
Corporation. 
 (i)    Valuation of Non-Cash Consideration. If any assets of the Corporation
distributed to stockholders in connection with any liquidation, dissolution, or winding up of the 

  
 -6-

 
Corporation are other than cash, then the value of such assets shall be their fair market value as determined in good faith by the Board of Directors, except that any securities to be
distributed to stockholders in a liquidation, dissolution, or winding up of the Corporation shall be valued as follows: 

(i)      If the securities are then traded on a national securities exchange or the Nasdaq Stock Market
System (or a similar national quotation system), then the value of the securities shall be deemed to be to the average of the closing prices of the securities on such exchange or system over the ten (10) trading day period ending five (5)
trading days prior to the distribution; 
 (ii)     if the securities are actively traded
over-the-counter, then the value of the securities shall be deemed to be the average of the closing bid prices of the securities over the ten (10) trading day period ending five (5) trading days prior to the distribution; or 

(iii)    if there is no active public market for the securities, then the value of the securities shall be deemed to
be the fair market value thereof as determined in good faith by the Board of Directors which determination shall include consideration of the illiquidity of the securities. 
 In the event of a merger or other acquisition of the Corporation by another entity, the distribution date shall be deemed to the date such transaction closes. 

For the purposes of this Section 4(i), “trading day” shall mean any day on which the exchange or system on which
the securities to be distributed are traded is open, and “closing prices” or “closing bid prices” shall be deemed to be: (i) for securities traded primarily on the New York Stock Exchange, the American Stock
Exchange or Nasdaq, the last reported trade price or sale price, as the case may be, at 4:00 p.m., New York time, on that day and (ii) for securities listed or traded on other exchanges, markets and systems, the market price as of the end
of the “regular hours” trading period that is generally accepted as such for such exchange, market or system. If, after the date hereof, the benchmark times generally accepted in the securities industry for determining the market price of
a stock as of a given trading day shall change from those set forth above, the fair market value shall be determined as of such other generally accepted benchmark times. 
 5.    Conversion. The holders of the Preferred Stock shall have conversion rights as follows (the “Conversion Rights”): 

(a)    Right to Convert. Subject to Section 5(c), each share of Preferred Stock shall be convertible, at
the option of the holder thereof, at any time after the date of issuance of such share at the office of the Corporation or any transfer agent for the Preferred Stock, into that number of fully-paid, nonassessable shares of Common Stock determined by
dividing the Original Issue Price for the relevant series by the Conversion Price for such series. (The number of shares of Common Stock into which each share of Preferred Stock of a series may be converted is hereinafter referred to as the
“Conversion Rate” for each such series.) Upon any decrease or increase in the Conversion Price for any series of Preferred Stock, as described in this Section 5, the Conversion Rate for such series shall be appropriately
increased or decreased. 

  
 -7-

 (b)    Automatic Conversion. Each share of Preferred Stock shall
automatically be converted into fully-paid, non-assessable shares of Common Stock at the then effective Conversion Rate for such share (i) immediately prior to the closing of a firm commitment underwritten initial public offering on Form S-1
(or successor form) filed under the Securities Act of 1933, as amended (the “Securities Act”), covering the offer and sale of the Corporation’s Common Stock, provided that the aggregate gross proceeds to the Corporation are not
less than $25,000,000, or (ii) upon the receipt by the Corporation of a written consent or request for such conversion from the holders of two-thirds of the shares of Preferred Stock then outstanding, or, if later, the effective date for
conversion specified in such requests (each of the events referred to in (i) and (ii) being hereinafter referred to as an “Automatic Conversion Event”). Notwithstanding the foregoing, if the Automatic Conversion Event does
not involve an initial public offering of the Company's Common Stock, then the Automatic Conversion Event shall not apply to the Series E Preferred Stock unless such Automatic Conversion Event is approved by the written consent of holders of more
than two-thirds of the shares of Series E Preferred Stock then outstanding.
 (c)    Mechanics of
Conversion. No fractional shares of Common Stock shall be issued upon conversion of Preferred Stock. In lieu of any fractional shares to which the holder would otherwise be entitled, the Corporation shall pay cash equal to such fraction
multiplied by the then fair market value of a share of Common Stock as determined by the Board of Directors. For such purpose, all shares of Preferred Stock held by each holder of Preferred Stock shall be aggregated, and any resulting fractional
share of Common Stock shall be paid in cash. Before any holder of Preferred Stock shall be entitled to convert the same into full shares of Common Stock, and to receive certificates therefor, he shall either surrender the certificate or certificates
therefor, duly endorsed, at the office of the Corporation or of any transfer agent for the Preferred Stock, or notify the Corporation or its transfer agent that such certificate or certificates have been lost, stolen or destroyed and execute an
agreement satisfactory to the Corporation to indemnify the Corporation from any loss incurred by it in connection with such certificate or certificates, and shall give written notice to the Corporation at such office that he elects to convert the
same; provided, however, that on the date of an Automatic Conversion Event, the outstanding shares of Preferred Stock shall be converted automatically without any further action by the holders of such shares and whether or not the
certificates representing such shares are surrendered to the Corporation or its transfer agent; provided further, however, that the Corporation shall not be obligated to issue certificates evidencing the shares of Common Stock issuable upon
such Automatic Conversion Event unless either the certificates evidencing such shares of Preferred Stock are delivered to the Corporation or its transfer agent as provided above, or the holder notifies the Corporation or its transfer agent that such
certificates have been lost, stolen or destroyed and executes an agreement satisfactory to the Corporation to indemnify the Corporation from any loss incurred by it in connection with such certificates. On the date of the occurrence of an Automatic
Conversion Event, each holder of record of shares of Preferred Stock shall be deemed to be the holder of record of the Common Stock issuable upon such conversion, notwithstanding that the certificates representing such shares of Preferred Stock
shall not have been surrendered at the office of the Corporation, that notice from the Corporation shall not have been received by any holder of record of shares of Preferred Stock, or that the certificates evidencing such shares of Common Stock
shall not then be actually delivered to such holder. 
 The Corporation shall, as soon as practicable after such delivery, or
after such agreement and indemnification, issue and deliver at such office to such holder of Preferred Stock, a certificate or 

  
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certificates for the number of shares of Common Stock to which he shall be entitled as aforesaid and a check payable to the holder in the amount of any cash amounts payable as the result of a
conversion into fractional shares of Common Stock, plus any declared and unpaid dividends on the converted Preferred Stock. Such conversion shall be deemed to have been made immediately prior to the close of business on the date of such surrender of
the shares of Preferred Stock to be converted, and the person or persons entitled to receive the shares of Common Stock issuable upon such conversion shall be treated for all purposes as the record holder or holders of such shares of Common Stock on
such date; provided, however, that if the conversion is in connection with an underwritten offer of securities registered pursuant to the Securities Act the conversion may, at the option of any holder tendering Preferred Stock for
conversion, be conditioned upon the closing of the sale of securities pursuant to such offering, in which event the person(s) entitled to receive the Common Stock issuable upon such conversion of the Preferred Stock shall not be deemed to have
converted such Preferred Stock until immediately prior to the closing of the sale of such securities. 

(d)    Adjustments to Conversion Price for Diluting Issues. 

(i)       Special Definition. For purposes of this Section 5(d), “Additional
Shares of Common” shall mean all shares of Common Stock issued (or, pursuant to Section 5(d)(iii), deemed to be issued) by the Corporation after the filing of this Certificate of Incorporation, other than: 

(1)    shares of Common Stock issued or issuable upon the conversion of the Preferred Stock; 

(2)    shares of Common Stock issued or issuable to officers, directors and employees of, or consultants and other
service providers to, the Corporation pursuant to stock grants, option plans, purchase plans or other employee stock incentive programs or arrangements approved by the Board of Directors or upon exercise of options or warrants granted to such
parties pursuant to any such plan, program or arrangement; 
 (3)    shares of Common Stock issued upon the
exercise or conversion of Options or Convertible Securities outstanding as of the date of the filing of this Certificate of Incorporation; 
 (4)    shares of Common Stock issued or issuable as a dividend or distribution on Preferred Stock or pursuant to any event for which adjustment is made pursuant to Section 5(e),
5(f) or 5(g) hereof; 
 (5)    shares of Common Stock issued in a registered public offering under the
Securities Act; 
 (6)    shares of Common Stock issued or issuable pursuant to the acquisition of another
corporation by the Corporation by merger, purchase of substantially all of the assets or other reorganization or to a joint venture agreement, provided, that such issuances are unanimously approved by the Board of Directors; 

  
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 (7)    shares of Common Stock issued or issuable to banks, equipment
lessors or other financial institutions pursuant to a commercial leasing or debt financing transaction approved by the Board of Directors; 
 (8)    shares of Common Stock issued or issuable in connection with sponsored research, collaboration, technology license, development, OEM, marketing or other similar agreements, or
strategic partnerships or relationships, if the issuance is approved by the Board of Directors; and 

(9)    shares of Common Stock issued upon the exercise or conversion of those Series E-1 Preferred Stock Warrants
issued pursuant to that certain Note and Warrant Purchase Agreement dated on or about
                     , 20    . 

(ii)      No Adjustment of Conversion Price. No adjustment in the Conversion
Price of a particular series of Preferred Stock shall be made in respect of the issuance of Additional Shares of Common unless the consideration per share (as determined pursuant to Section 5(d)(ix)) for an Additional Share of Common issued or
deemed to be issued by the Corporation is less than the Conversion Price in effect on the date of, and immediately prior to such issue, for such series of Preferred Stock. 
 (iii)     Deemed Issue of Additional Shares of Common. In the event the Corporation at any time or from time to time after the date of the filing of this Certificate of
Incorporation shall issue any Options or Convertible Securities or shall fix a record date for the determination of holders of any class of securities entitled to receive any such Options or Convertible Securities, then the maximum number of shares
(as set forth in the instrument relating thereto without regard to any provisions contained therein for a subsequent adjustment of such number) of Common Stock issuable upon the exercise of such Options or, in the case of Convertible Securities, the
conversion or exchange of such Convertible Securities or, in the case of Options for Convertible Securities, the exercise of such Options and the conversion or exchange of the underlying securities, shall be deemed to have been issued as of the time
of such issue or, in case such a record date shall have been fixed, as of the close of business on such record date, provided that in any such case in which shares are deemed to be issued: 

(1)    no further adjustment in the Conversion Price of the Preferred Stock shall be made upon the subsequent issue
of Convertible Securities or shares of Common Stock in connection with the exercise of such Options or conversion or exchange of such Convertible Securities pursuant to the terms of such Options or Convertible Securities; 

(2)    if no adjustment in the Conversion Price of the Preferred Stock was made upon the original issue of (or upon
the occurrence of a record date with respect to) such Options or Convertible Securities and such Options or Convertible Securities are revised to provide, or by their terms provide, with the passage of time or otherwise, for any increase or decrease
in the consideration payable to the Corporation, or any increase or decrease in the number of shares of Common Stock issuable, upon the exercise, conversion or exchange thereof, then such Options or Convertible Securities as so revised (and the
Additional Shares of Common subject thereto) shall be deemed to have been issued effective upon such increase or decrease becoming effective; 

  
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 (3)    if such Options or Convertible Securities are revised to
provide, or by their terms provide, with the passage of time or otherwise, for any increase or decrease in the consideration payable to the Corporation, or any increase or decrease in the number of shares of Common Stock issuable, upon the exercise,
conversion or exchange thereof, the Conversion Price of the Preferred Stock computed upon the original issue thereof (or upon the occurrence of a record date with respect thereto), and any subsequent adjustments based thereon, shall, upon any such
increase or decrease becoming effective, be recomputed to reflect such increase or decrease insofar as it affects such Options or the rights of conversion or exchange under such Convertible Securities; 

(4)    no readjustment pursuant to clause (3) above shall have the effect of increasing the Conversion Price of
the Preferred Stock to an amount which exceeds the lower of (i) the Conversion Price of the Preferred Stock on the original adjustment date, or (ii) the Conversion Price of the Preferred Stock that would have resulted from any issuance of
Additional Shares of Common between the original adjustment date and such readjustment date; 
 (5)    upon
the expiration of any such Options or any rights of conversion or exchange under such Convertible Securities which shall not have been exercised, the Conversion Price computed upon the original issue thereof (or upon the occurrence of a record date
with respect thereto) and any subsequent adjustments based thereon shall, upon such expiration, be recomputed as if: 

(A)   in the case of Convertible Securities or Options for Common Stock, the only Additional Shares of Common issued were the
shares of Common Stock, if any, actually issued upon the exercise of such Options or the conversion or exchange of such Convertible Securities and the consideration received therefor was the consideration actually received by the Corporation for the
issue of such exercised Options plus the consideration actually received by the Corporation upon such exercise or for the issue of all such Convertible Securities which were actually converted or exchanged, plus the additional consideration, if any,
actually received by the Corporation upon such conversion or exchange, and 
 (B)   in the case of Options for
Convertible Securities, only the Convertible Securities, if any, actually issued upon the exercise thereof were issued at the time of issue of such Options, and the consideration received by the Corporation for the Additional Shares of Common deemed
to have been then issued was the consideration actually received by the Corporation for the issue of such exercised Options, plus the consideration deemed to have been received by the Corporation (determined pursuant to Section 5(d)(ix)) upon
the issue of the Convertible Securities with respect to which such Options were actually exercised; and 

(6)    if such record date shall have been fixed and such Options or Convertible Securities are not issued on the
date fixed therefor, the adjustment previously made in the Conversion Price which became effective on such record date shall be canceled as of the close of business on such record date, and thereafter the Conversion Price shall be adjusted pursuant
to this Section 5(d)(iii) as of the actual date of their issuance. 
 (iv)     Adjustment of
Conversion Price of Series E Preferred Stock Upon Issuance of Additional Shares of Common. 

  
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 (1)    For so long as the Conversion Price of the Series E
Preferred Stock is greater than $9.03 (as adjusted for subdivisions and combinations of the Common Stock and changes in the Common Stock as set forth in Sections 5(e) and 5(g)) (the “Series D/E Ratchet Amount”), in the event
this Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)), for a consideration per share less than the applicable Conversion Price of the Series E
Preferred Stock in effect on the date of and immediately prior to such issue, but for a consideration per share equal to or greater than the Series D/E Ratchet Amount, then the Conversion Price of the Series E Preferred Stock shall be reduced
concurrently with such issue to a price (calculated to the nearest cent) equal to the per share price of the Additional Shares of Common. 
 (2)    In the event the Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without
consideration or for a consideration per share less than the Series D/E Ratchet Amount, then the Conversion Price of the Series E Preferred Stock immediately prior to such issue shall be deemed to be equal to the Series D/E Ratchet Amount (the
“Series E Adjusted Conversion Price”), and such Series E Adjusted Conversion Price shall be further reduced, concurrently with such issue, to a price (calculated to the nearest cent) determined by multiplying such Series E Adjusted
Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of shares of Common Stock which the aggregate consideration received by the Corporation
for the total number of Additional Shares of Common so issued would purchase at such Adjusted Conversion Price, and the denominator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of
such Additional Shares of Common so issued. For the purposes of this Section 5(d)(iv)(2), all shares of Common Stock issuable upon exercise of outstanding Options or the conversion of outstanding Convertible Securities and shares of Preferred
Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed to be outstanding. Section 5(d)(iv)(3) shall govern adjustments to the Conversion Price of the Series E Preferred Stock after
the first adjustment to the Conversion Price of the Series E Preferred Stock pursuant to this Section 5(d)(iv)(2). 

(3)    After any adjustment to the Conversion Price of the Series E Preferred Stock pursuant to
Section 5(d)(iv)(2), in the event the Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without consideration or for a consideration per share less
than the Conversion Price of the Series E Preferred Stock in effect on the date of and immediately prior to such issue, then, the Conversion Price of the Series E Preferred Stock shall be reduced concurrently with such issue, to a price (calculated
to the nearest cent) determined by multiplying such Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of shares of Common Stock which the
aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Conversion Price, and the denominator of which shall be the number of shares of Common Stock outstanding
immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this Section 5(d)(iv)(3), all shares of Common Stock issuable upon exercise of outstanding Options or the conversion of
outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed to be outstanding. 

  
 -12-

 (v)        Adjustment of Conversion Price of
Series E-1 Preferred Stock Upon Issuance of Additional Shares of Common. In the event the Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without
consideration or for a consideration per share less than the Conversion Price of the Series E-1 Preferred Stock in effect on the date of and immediately prior to such issue, then, the Conversion Price of the Series E-1 Preferred Stock shall be
reduced concurrently with such issue, to a price (calculated to the nearest cent) determined by multiplying such Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to
such issue plus the number of shares of Common Stock which the aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Conversion Price, and the denominator of which
shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this Section 5(d)(v), all shares of Common Stock issuable upon exercise
of outstanding Options or the conversion of outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed to be outstanding. 

(vi)        Adjustment of Conversion Price of Series D Preferred Stock Upon Issuance of
Additional Shares of Common. 
       (1)    For so long as the
Conversion Price of the Series D Preferred Stock is greater than the Series D/E Ratchet Amount, in the event this Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to
Section 5(d)(iii)) for a consideration per share less than the applicable Conversion Price of the Series D Preferred Stock in effect on the date of and immediately prior to such issue, but for a consideration per share equal to or greater than
the Series D/E Ratchet Amount, then the Conversion Price of the Series D Preferred Stock shall be reduced concurrently with such issue to a price (calculated to the nearest cent) equal to the per share price of the Additional Shares of Common.

       (2)    In the event this Corporation shall issue Additional Shares
of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without consideration or for a consideration per share less than the Series D/E Ratchet Amount, then the Conversion Price of the Series D
Preferred Stock immediately prior to such issue shall be deemed to be equal to the Series D/E Ratchet Amount (the “Series D Adjusted Conversion Price”), and such Series D Adjusted Conversion Price shall be further reduced,
concurrently with such issue, to a price (calculated to the nearest cent) determined by multiplying such Series D Adjusted Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding
immediately prior to such issue plus the number of shares of Common Stock which the aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Series D Adjusted
Conversion Price, and the denominator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this
Section 5(d)(vi)(2), all shares of Common Stock issuable upon exercise of outstanding Options or the conversion of outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to
Section 5(d)(iii) hereof, shall be deemed to be outstanding. Section 5(d)(vi)(3) shall govern adjustments to the Conversion 

  
 -13-

 
Price of the Series D Preferred Stock after the first adjustment to the Conversion Price of the Series D Preferred Stock pursuant to this Section 5(d)(vi)(2). 

      (3)    After any adjustment to the Conversion Price of the Series D Preferred
Stock pursuant to Section 5(d)(vi)(2), in the event this Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without consideration or for a
consideration per share less than Conversion Price of the Series D Preferred Stock in effect on the date of and immediately prior to such issue, then, the Conversion Price of the Series D Preferred Stock shall be reduced concurrently with such
issue, to a price (calculated to the nearest cent) determined by multiplying such Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of
shares of Common Stock which the aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Conversion Price, and the denominator of which shall be the number of shares of
Common Stock outstanding immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this Section 5(d)(vi)(3), all shares of Common Stock issuable upon exercise of outstanding Options or
the conversion of outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed to be outstanding. 

(vii)        Adjustment of Conversion Price of Series D-1 Preferred Stock Upon Issuance of
Additional Shares of Common.  In the event this Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without consideration or for a
consideration per share less than Conversion Price of the Series D-1 Preferred Stock in effect on the date of and immediately prior to such issue, then, the Conversion Price of the Series D-1 Preferred Stock shall be reduced concurrently with such
issue, to a price (calculated to the nearest cent) determined by multiplying such Conversion Price by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of
shares of Common Stock which the aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Conversion Price, and the denominator of which shall be the number of shares of
Common Stock outstanding immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this Section 5(d)(vii), all shares of Common Stock issuable upon exercise of outstanding Options or the
conversion of outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed to be outstanding. 

(viii)        Adjustment of Conversion Price of Series A, B and C Preferred Stock Upon
Issuance of Additional Shares of Common.  In the event the Corporation shall issue Additional Shares of Common (including Additional Shares of Common deemed to be issued pursuant to Section 5(d)(iii)) without consideration or for
a consideration per share less than the applicable Conversion Price of the Series A Preferred Stock, Series B Preferred Stock or Series C Preferred Stock in effect on the date of and immediately prior to such issue, then, the Conversion Price
of the Series A Preferred Stock, Series B Preferred Stock or Series C Preferred Stock (if affected) shall be reduced, concurrently with such issue, to a price (calculated to the nearest cent) determined by multiplying such Conversion Price by a
fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of shares of 

  
 -14-

 
Common Stock which the aggregate consideration received by the Corporation for the total number of Additional Shares of Common so issued would purchase at such Conversion Price, and the
denominator of which shall be the number of shares of Common Stock outstanding immediately prior to such issue plus the number of such Additional Shares of Common so issued. For the purposes of this Section 5(d)(viii), all shares of Common
Stock issuable upon exercise of outstanding Options or the conversion of outstanding Convertible Securities and shares of Preferred Stock, and all Additional Shares of Common deemed issued pursuant to Section 5(d)(iii) hereof, shall be deemed
to be outstanding. 
 (ix)    Determination of Consideration. For purposes of this
Section 5(d), the consideration received by the Corporation for the issue (or deemed issue) of any Additional Shares of Common shall be computed as follows: 
   (1)    Cash and Property. Such consideration shall: 
       (A)    insofar as it consists of cash, be computed at the aggregate amount of cash received by the Corporation before deducting reasonable
discounts, commissions or other expenses allowed, paid or incurred by the Corporation for any underwriting or otherwise in connection with such issue (or deemed issue); 
       (B)    insofar as it consists of property other than cash, be computed at the fair market value thereof at the time of such issue, as determined in
good faith by the Board of Directors; and 
       (C)    in the event
Additional Shares of Common are issued together with other shares or securities or other assets of the Corporation for consideration which covers both, be the proportion of such consideration so received, computed as provided in clauses (A) and
(B) above, as reasonably determined in good faith by the Board of Directors. 

  (2)    Options and Convertible Securities. The consideration per share received by
the Corporation for Additional Shares of Common deemed to have been issued pursuant to Section 5(d)(iii) shall be determined by dividing: 
       (X)    the total amount, if any, received or receivable by the Corporation as consideration for the issue of such Options or Convertible Securities,
plus the minimum aggregate amount of additional consideration (as set forth in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such consideration) payable to the Corporation upon the
exercise of such Options or the conversion or exchange of such Convertible Securities, or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible
Securities by 
       (Y)    the maximum number of shares of Common Stock
(as set forth in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such number) issuable upon the exercise of such Options or the conversion or exchange of such Convertible Securities.

  
 -15-

 (e)    Adjustments for Subdivisions or Combinations of Common
Stock. In the event the outstanding shares of Common Stock shall be subdivided (by stock split, by payment of a stock dividend or otherwise), into a greater number of shares of Common Stock, the Conversion Price of each series of Preferred Stock
in effect immediately prior to such subdivision shall, concurrently with the effectiveness of such subdivision, be proportionately decreased. In the event the outstanding shares of Common Stock shall be combined (by reclassification or otherwise)
into a lesser number of shares of Common Stock, the Conversion Prices in effect immediately prior to such combination shall, concurrently with the effectiveness of such combination, be proportionately increased. 

(f)    Adjustments for Subdivisions or Combinations of Preferred Stock. In the event the outstanding shares
of Preferred Stock or a series of Preferred Stock shall be subdivided (by stock split, by payment of a stock dividend or otherwise), into a greater number of shares of Preferred Stock, the Dividend Rate, Original Issue Price and Liquidation
Preference of the affected series of Preferred Stock in effect immediately prior to such subdivision shall, concurrently with the effectiveness of such subdivision, be proportionately decreased. In the event the outstanding shares of Preferred Stock
or a series of Preferred Stock shall be combined (by reclassification or otherwise) into a lesser number of shares of Preferred Stock, the Dividend Rate, Original Issue Price and Liquidation Preference of the affected series of Preferred Stock in
effect immediately prior to such combination shall, concurrently with the effectiveness of such combination, be proportionately increased. 
 (g)    Adjustments for Reclassification, Exchange and Substitution. Subject to Section 4 above (“Liquidation Rights”), if the Common Stock issuable upon
conversion of the Preferred Stock shall be changed into the same or a different number of shares of any other class or classes of stock, whether by capital reorganization, reclassification or otherwise (other than a subdivision or combination of
shares provided for above), then, in any such event, in lieu of the number of shares of Common Stock which the holders would otherwise have been entitled to receive, each holder of such Preferred Stock shall have the right thereafter to convert such
shares of Preferred Stock into a number of shares of such other class or classes of stock which a holder of the number of shares of Common Stock deliverable upon conversion of such series of Preferred Stock immediately before that change would have
been entitled to receive in such reorganization or reclassification, all subject to further adjustment as provided herein with respect to such other shares. 
 (h)    No Impairment. The Corporation will not through any reorganization, transfer of assets, merger, dissolution, issue or sale of securities or any other voluntary action,
avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Corporation but will at all times in good faith assist in the carrying out of all the provisions of this Section 5 and in the
taking of all such action as may be necessary or appropriate in order to protect the Conversion Rights of the holders of Preferred Stock against impairment. Notwithstanding the foregoing, nothing in this Section 5(h) shall prohibit the
Corporation from amending its Certificate of Incorporation with the requisite consent of its stockholders and the board of directors. 
 (i)    Certificate as to Adjustments. Upon the occurrence of each adjustment or readjustment of the Conversion Price pursuant to this Section 5, the Corporation at its
expense shall promptly compute such adjustment or readjustment in accordance with the terms hereof and furnish to each holder of Preferred Stock a certificate setting forth such adjustment or readjustment and showing in detail the facts upon which
such adjustment or readjustment is based. The Corporation 

  
 -16-

 
shall, upon the written request at any time of any holder of Preferred Stock, furnish or cause to be furnished to such holder a like certificate setting forth (i) such adjustments and
readjustments, (ii) the Conversion Price at the time in effect and (iii) the number of shares of Common Stock and the amount, if any, of other property which at the time would be received upon the conversion of Preferred Stock. 

(j)    Notices of Record Date. In the event that the Corporation shall propose at any time:

 (i)    to declare any dividend or distribution upon its Common Stock, whether in cash, property, stock
or other securities, whether or not a regular cash dividend and whether or not out of earnings or earned surplus; 

(ii)    to effect any reclassification or recapitalization of its Common Stock outstanding involving a change in the
Common Stock; or 
 (iii)    to voluntarily liquidate or dissolve or to enter into any transaction deemed
to be a liquidation, dissolution or winding up of the corporation pursuant to Section 4(h); 
 then, in connection with each such event,
the Corporation shall send to the holders of the Preferred Stock at least 14 days’ prior written notice of the date on which a record shall be taken for such dividend or distribution (and specifying the date on which the holders of Common Stock
shall be entitled thereto) or for determining rights to vote in respect of the matters referred to in (ii) and (iii) above. 
 Each such written notice shall be given by first class mail, postage prepaid, addressed to the holders of Preferred Stock at the address for each such holder as shown on the books of the Corporation.

 The right of the holders of the Preferred Stock to notice hereunder may be waived by the holders of more than two-thirds ( 2/3) of the outstanding shares of the Preferred Stock
voting together as a single class. Notwithstanding the foregoing, no waiver of notice under this Section 5(j) shall constitute a waiver of notice with respect to the Series E Preferred Stock or Series E-1 Preferred Stock unless such
waiver shall have been approved by the written consent of holders of more than
two-thirds ( 2/3) of the shares of
Series E Preferred Stock and Series E-1 Preferred Stock then outstanding, voting together as a single class. 
 (k)    Reservation of Stock Issuable Upon Conversion.  The Corporation shall at all times reserve and keep available out of its authorized but
unissued shares of Common Stock solely for the purpose of effecting the conversion of the shares of the Preferred Stock, such number of its shares of Common Stock as shall from time to time be sufficient to effect the conversion of all then
outstanding shares of the Preferred Stock; and if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient to effect the conversion of all then outstanding shares of the Preferred Stock, the Corporation will
take such corporate action as may, in the opinion of its counsel, be necessary to increase its authorized but unissued shares of Common Stock to such number of shares as shall be sufficient for such purpose. 

  
 -17-

 (l)    Waiver of Adjustment of Conversion Price. Notwithstanding
anything herein to the contrary, any downward adjustment of the Conversion Price of any series of Preferred Stock may be waived by the consent or vote of the holders of more than two-thirds ( 2/3) of the outstanding shares of such series. Any such waiver shall
bind all future holders of shares of such series of Preferred Stock. 
 6.    Voting.

 (a)    Restricted Class Voting.  Except as otherwise expressly provided herein or as
required by law, the holders of Preferred Stock and the holders of Common Stock shall vote together and not as separate classes. 
 (b)    No Series Voting.  Other than as provided herein or required by law, there shall be no series voting. 

(c)    Preferred Stock.  Each holder of Preferred Stock shall be entitled to the number of votes
equal to the number of shares of Common Stock into which the shares of Preferred Stock held by such holder could be converted as of the record date. The holders of shares of the Preferred Stock shall be entitled to vote on all matters on which the
Common Stock shall be entitled to vote. Holders of Preferred Stock shall be entitled to notice of any stockholders’ meeting in accordance with the Bylaws of the Corporation. Fractional votes shall not, however, be permitted and any fractional
voting rights resulting from the above formula (after aggregating all shares into which shares of Preferred Stock held by each holder could be converted), shall be disregarded. 

(d)    Common Stock.  Each holder of shares of Common Stock shall be entitled to one vote for each
share thereof held. 
 (e)    Adjustment in Authorized Common Stock.  The number of
authorized shares of Common Stock may be increased or decreased (but not below the number of shares of Common Stock then outstanding) by an affirmative vote of the holders of a majority of the outstanding Common Stock and Preferred Stock, voting
together as a single class. 
 (f)    Election of Directors.  So long as at least 571,428
shares of Series D Preferred Stock (as adjusted for stock splits, subdivisions, combinations or stock dividends with respect to such shares) remain outstanding, the holders of the Series D Preferred Stock, voting as a separate class, shall
be entitled to elect two (2) members of the Corporation’s Board of Directors at each meeting or pursuant to each consent of the Corporation’s stockholders for the election of directors. So long as at least 571,428 shares of
Series C Preferred Stock (as adjusted for stock splits, subdivisions, combinations or stock dividends with respect to such shares) remain outstanding, the holders of Series C Preferred Stock, voting as a separate class, shall be entitled
to elect three (3) members of the Corporation’s Board of Directors at each meeting or pursuant to each consent of the Corporation’s stockholders for the election of directors. Any additional members of the Corporation’s Board of
Directors shall be elected by the holders of Common Stock, Series A Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and
Series E-1 Preferred Stock, voting together as a single class. 

  
 -18-

 7.    Amendments and Changes Requiring Approval of Preferred
Stock.  As long as any of the Preferred Stock shall be issued and outstanding, the Corporation shall not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least two-thirds ( 2/3) of the outstanding shares of the Preferred Stock
voting together as a single class: 
 (a)    amend, alter or repeal any provision of the Certificate
of Incorporation or By-laws of the Corporation (including pursuant to a merger) if such action would adversely alter the rights, preferences, privileges or powers of, or restrictions provided for the benefit of the Preferred Stock or any series
thereof; 
 (b)    enter into any transaction or series of related transactions deemed to be a liquidation,
dissolution or winding up of the Corporation pursuant to Section 4(h) above; 
 (c)    voluntarily
liquidate or dissolve; 
 (d)    declare or pay any distribution (as defined in Section 3(d) except
for distributions upon a liquidation or dissolution) with respect to the Common Stock of the Corporation; 

(e)    permit any subsidiary of the Corporation to sell securities to a third party (other than directors’
qualifying shares in the case of subsidiaries outside the United States); 
 (f)    increase or decrease
(other than for decreases resulting from conversion of the Preferred Stock) the authorized number of shares of Preferred Stock; 
 (g)    authorize or create (by reclassification, merger or otherwise) any new class or series of capital stock having rights, preferences or privileges with respect to dividends,
liquidation, redemption, conversion or other rights senior to or on a parity with any series of Preferred Stock or with respect to voting senior to any series of Preferred Stock; 

(h)    increase or decrease the authorized number of directors of the Corporation; or 

(i)    amend this Section 7. 
 8.    Amendments and Changes Requiring the Approval of the Series E Preferred Stock and Series E-1 Preferred Stock. 

(a)    As long as any of the Series E Preferred Stock shall be issued and outstanding, the Corporation shall
not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least 60% of the outstanding shares of the Series E Preferred Stock and Series E-1 Preferred Stock voting together as a single
class: 
 (i)    amend, alter or repeal any provision of the Certificate of Incorporation of the
Corporation (including pursuant to a merger) if such action would adversely alter the rights, preferences, privileges or powers of, or restrictions provided for the benefit of the Series E Preferred Stock in a manner different from any other
series of Preferred Stock; or 
 (ii)     amend this Section 8(a). 

  
 -19-

 (b)    As long as any of the Series E Preferred Stock shall be
issued and outstanding, the Corporation shall not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least a majority of the outstanding shares of the Series E Preferred Stock and
Series E-1 Preferred Stock voting together as a single class: 
 (i)    declare or pay any
distribution (as defined in Section 3(d) except for distributions upon a liquidation or dissolution) with respect to the Common Stock or Preferred Stock of the Corporation; or 

(ii)    amend this Section 8(b). 
 (c)    As long as any of the Series E Preferred Stock shall be issued and outstanding, the Corporation shall not, without first obtaining the approval (by vote or written consent
as provided by law) of the holders of at least 66  2/3% of the outstanding shares of the Series D Preferred Stock, Series D-1 Preferred Stock, Series E Preferred Stock and Series E-1 Preferred Stock voting together as a single class on an
as converted to Common Stock basis: 
 (i)    increase or decrease (other than for decreases
resulting from conversion of the Preferred Stock) the authorized number of shares of Series E Preferred Stock; 

(ii)     authorize or create (by reclassification, merger or otherwise) any new class or series of capital stock
having rights, preferences or privileges with respect to dividends, payments upon liquidation or other rights senior to or on a parity with the Series E Preferred Stock or with respect to voting senior to the Series E Preferred Stock; or

 (iii)    amend this Section 8(c). 

9.    Amendments and Changes Requiring the Approval of the Series D Preferred Stock and Series D-1
Preferred Stock. 
 (a)    As long as any of the Series D Preferred Stock shall be issued and
outstanding, the Corporation shall not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least 60% of the outstanding shares of the Series D Preferred Stock and Series D-1 Preferred
Stock voting together as a single class: 
 (i)    amend, alter or repeal any provision of the Certificate
of Incorporation of the Corporation if such action would adversely alter the rights, preferences, privileges or powers of, or restrictions provided for the benefit of the Series D Preferred Stock in a manner different from any other series of
Preferred Stock; or 
 (ii)    amend this Section 9(a). 

(b)    As long as any of the Series D Preferred Stock shall be issued and outstanding, the Corporation shall
not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least a majority of the outstanding shares of the Series D Preferred Stock and Series D-1 Preferred Stock voting together as a
single class: 

  
 -20-

 (i)    increase or decrease (other than for decreases resulting from
conversion of the Preferred Stock) the authorized number of shares of Series D Preferred Stock; 

(ii)    authorize or create (by reclassification or otherwise) any new class or series of capital stock having
rights, preferences or privileges with respect to dividends, payments upon liquidation or other rights senior to or on a parity with the Series D Preferred Stock or with respect to voting senior to the Series D Preferred Stock; 

(iii)    declare or pay any distribution (as defined in Section 3(d) except for distributions upon a
liquidation or dissolution) with respect to the Common Stock or Preferred Stock of the Corporation; 

(iv)    increase the authorized number of directors of the Corporation above eleven (11); or 

(v)    amend this Section 9(b). 
 10.    Amendments and Changes Requiring the Approval of the Series C Preferred Stock. As long as any of the Series C Preferred Stock shall be issued and outstanding,
the Corporation shall not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least two-thirds
( 2/3) of the outstanding shares of the
Series C Preferred Stock: 
 (a)    amend, alter or repeal any provision of the Certificate of
Incorporation of the Corporation if such action would adversely alter the rights, preferences, privileges or powers of, or restrictions provided for the benefit of the Series C Preferred Stock in a manner different from any other series of
Preferred Stock; 
 (b)    increase or decrease (other than for decreases resulting from conversion of the
Preferred Stock) the authorized number of shares of Series C Preferred Stock; 
 (c)    authorize or
create (by reclassification or otherwise) any new class or series of capital stock having rights, preferences or privileges with respect to dividends, payments upon liquidation or other rights senior to or on a parity with the Series C
Preferred Stock or with respect to voting senior to the Series C Preferred Stock; 
 (d)    declare or
pay any distribution (as defined in Section 3(d) except for distributions upon a liquidation or dissolution) with respect to the Common Stock or Preferred Stock of the Corporation; 

(e)    increase the authorized number of directors of the Corporation above eleven (11); or 

(f)    amend this Section 10. 
 11.    Amendments and Changes Requiring the Approval of the Series B Preferred Stock.  As long as any of the Series B Preferred Stock shall be issued and
outstanding, the Corporation shall not, without first obtaining the approval (by vote or written consent as provided by law) of the holders of at least two-thirds of the outstanding shares of the Series B Preferred Stock: 

  
 -21-

 (a)    amend, alter or repeal any provision of the Certificate of
Incorporation of the Corporation if such action would adversely alter the rights, preferences, privileges or powers of, or restrictions provided for the benefit of the Series B Preferred Stock in a manner different from any other series of
Preferred Stock; 
 (b)    increase or decrease (other than for decreases resulting from conversion of the
Preferred Stock) the authorized number of shares of Series B Preferred Stock; or 
 (c)    amend this
Section 11. 
 12.    Status of Converted Stock.  In the event any shares of Preferred
Stock shall be converted pursuant to Section 5 hereof, then the shares so converted shall be cancelled and shall not be issuable by the Corporation. The Certificate of Incorporation shall be appropriately amended to effect the corresponding
reduction in the Corporation’s authorized capital stock. 
 13.    Notices.  Any
notice required by the provisions of this Article IV to be given to the holders of Preferred Stock shall be deemed given if deposited in the United States mail, postage prepaid, and addressed to each holder of record at such holder’s
address appearing on the books of the Corporation. 
 ARTICLE V 

The Corporation reserves the right to amend, alter, change, or repeal any provision contained in this Certificate of Incorporation, in
the manner now or hereafter prescribed by statute, and all rights conferred upon the stockholders herein are granted subject to this right. 
 ARTICLE VI 
 The Corporation is to have perpetual existence. 

ARTICLE VII 

Elections of directors need not be by written ballot unless a stockholder demands election by written ballot at the meeting and before
voting begins or unless the Bylaws of the Corporation shall so provide. 
 ARTICLE VIII 

Unless otherwise set forth herein, the number of directors which constitute the Board of Directors of the Corporation shall be designated
in the Bylaws of the Corporation. 

  
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 ARTICLE IX 
 In furtherance and not in limitation of the powers conferred by statute, the Board of Directors is expressly authorized to make, alter, amend or repeal the Bylaws of the Corporation. 

ARTICLE X 

1.    Limitation of Directors’ Liability.  To the fullest extent permitted by the General
Corporation Law of the State of Delaware as the same exists or as may hereafter be amended, a director of the Corporation shall not be personally liable to the Corporation or its stockholders for monetary damages for breach of fiduciary duty as a
director. 
 2.    Indemnification.  The Corporation may indemnify to the fullest extent
permitted by law any person made or threatened to be made a party to an action or proceeding, whether criminal, civil, administrative or investigative, by reason of the fact that such person or his or her testator or intestate is or was a director,
officer or employee of the Corporation, or any predecessor of the Corporation, or serves or served at any other enterprise as a director, officer or employee at the request of the Corporation or any predecessor to the Corporation. 

3.    Amendments.  Neither any amendment nor repeal of this Article X, nor the adoption of any
provision of the Corporation’s Certificate of Incorporation inconsistent with this Article X, shall eliminate or reduce the effect of this Article X, in respect of any matter occurring, or any action or proceeding accruing or arising
or that, but for this Article X, would accrue or arise, prior to such amendment, repeal, or adoption of an inconsistent provision. 
 ARTICLE XI 
 Meetings of the stockholders may be held within or without the State
of Delaware, as the Bylaws may provide. The books of the Corporation may be kept (subject to any provision contained in the statutes) outside of the State of Delaware at such place or places as may be designated from time to time by the Board of
Directors or in the Bylaws of the Corporation. 
 *  *  * 

  
 -23-Lease Agreement

 Exhibit 10.19 
 7000 Shoreline/Fluidigm - Page 1 
 LEASE AGREEMENT 

THIS LEASE AGREEMENT (this “Lease”) is made as of this September 14, 2010 (the “Execution
Date”), between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation (“Tenant”). 

RECITALS 

A.        Oscient Pharmaceuticals Corporation, a Massachusetts corporation
(“Oscient”) (as successor-in-interest to Genesoft, Inc.), and Landlord (as successor-in-interest to MJ Research Company, Inc.) were parties to that certain Agreement of Lease dated as of October 6, 2000 (the “Oscient
Lease”) whereby Landlord leased to Oscient a portion of the Building (as hereinafter defined) (the “Oscient Premises”). 
 B.        Tenant subleased from Oscient a portion of the Oscient Premises described below as “Premises West” pursuant to that certain Sublease Agreement dated as of
March 25, 2004 (the “Original Oscient Sublease”), as amended by that certain First Amendment to Sublease by and between Tenant and Oscient dated December 7, 2007 (as amended, the “Oscient Sublease”).
Landlord, Tenant and Oscient entered into that certain Consent to Sublease dated December 7, 2007 whereby Landlord consented to the Oscient Sublease (the “Premises West Consent Agreement”). 

C.        By letter dated September 8, 2009, from Landlord’s counsel to Tenant,
Landlord notified Tenant that (i) pursuant to a Bankruptcy Order dated September 4, 2009, Oscient rejected the Oscient Lease and the Oscient Sublease, and (ii) Landlord exercised its contractual right and/or election to reinstate the
Oscient Sublease and have Tenant attorn to Landlord, whereby the Oscient Sublease became a direct lease between Landlord and Tenant (the “Oscient Space Attornment Agreement”). As a result Tenant now leases Premises West under a
direct lease between Landlord and Tenant under the terms of the Oscient Sublease. 

D.        Tenant and Landlord (as successor-in-interest to MJ Research Company, Inc.) are
parties to that certain Agreement of Lease dated as of December 1, 2001, as amended by that certain First Amendment to Sublease dated March 25, 2004, as further amended by that certain Second Amendment to Lease dated as of
November 29, 2004, as further amended by that certain Third Amendment to Lease dated November 30, 2007 (as amended, the “Premises East Lease”) whereby Landlord leases to Tenant a portion of the Building described below as
“Premises East”. 
 E.        Landlord and Tenant now desire to among
other things (i) terminate the Oscient Sublease and the Oscient Space Attornment Agreement and provide for Tenant’s leasing of Premises West on the terms and conditions set forth in this Lease and (ii) terminate the Premises East
Lease and provide for Tenant’s leasing of Premises East on the terms and conditions set forth in this Lease. 
 BASIC LEASE PROVISIONS

  

					
		 	 Address:
	  	 7000 Shoreline Court, South San Francisco, California

			
		 	 Premises:
	  	 Subject to Section 40 below, that portion of the Project, containing approximately 37,496 rentable square feet (“RSF”), consisting of
(a) a portion of the Project as shown on Exhibit A-1 (“Premises West”), and (b) a portion of the Project as shown on Exhibit A-2 (“Premises East”).

			
		 	 Project:
	  	 The real property on which the building (the “Building”) in which the Premises are located, together with all improvements thereon and appurtenances
thereto as described on Exhibit B.

  
 7000
Shoreline/Fluidigm - Page 2 

 Base Rent: 
  

							
	 	 	Period	  	Monthly Base Rent	  	 
		 	 May 1, 2010 - December 31, 2010
	  	$58,672.76	  	
		 	 January 1, 2011 - February 28, 2011
	  	$60,191.01	  	
		 	 March 1, 2011 —March 31, 2011
	  	$59,527.20	  	
		 	 April 1, 2011 - February 28, 2012
	  	$61,527.20	  	
		 	 March 1, 2012 - February 28, 2013
	  	$64,007,50	  	
		 	 March 1, 2013 - February 28, 2014
	  	$66,487.80	  	
		 	 March 1, 2014 - April 30,
2015
	  	$70,208.25	  	

 Rentable Area of Premises:     37,496 RSF 

Rentable Area of Project:         136,393 RSF 

Tenant’s Share of Operating Expenses: 
  

							
	 	 	Period	  	Tenant’s Share	  	 
		 	 May 1, 2010 - February 28, 2011
	  	  6.98%	  	
		 	 March 1, 2011 - April 30, 2015
	  	18.19%	  	
		 	 Extension Term (if
any)
	  	21.43%	  	

 **Landlord and Tenant acknowledge and agree that the amounts of Tenant’s Share as set
forth in the table above are agreed-upon amounts and do not reflect the proportion that the Rentable Area of the Premises bears to the-Rentable Area of the Project 
  

					
		 	 Security Deposit:
	 	 $60,000.00

			
		 	 Base Term:
	 	 A term beginning on May 1, 2010 (the “Commencement Date”) and ending on April 30, 2015

			
		 	 Permitted Use:
	 	 Research and development laboratory, manufacturing, diagnostics, related office and other related uses consistent with the character of the Project and otherwise in
compliance with the provisions of Section 7 hereof.

  

			
	Address for Rent Payment:	  	Landlord’s Notice Address
	 P.O. Box 51783
 Los Angeles, CA
90051-6083
	  	 385 E. Colorado Boulevard, Suite 299
 Pasadena,
CA 91101
 Attention: Corporate Secretary

		
	 Tenant’s Notice Address:
	  	
	 7000 Shoreline Court
 South San Francisco, CA
94080
 Attention: General Counsel
	  	

 The following Exhibits and Addenda are attached hereto and incorporated herein by this
reference: 
  

					
		  	[X]	    	EXHIBIT A-1 - PREMISES WEST DESCRIPTION
		  	[X]	    	EXHIBIT A-2 - PREMISES EAST DESCRIPTION
		  	[X]	    	EXHIBIT A-3 - GIVE-BACK SPACE
		  	[X]	    	EXHIBIT B - DESCRIPTION OF PROJECT
		  	[X]	    	EXHIBIT C - WORK LETTER
		  	[X]	    	EXHIBIT D - SHARED AREA

  7000 Shoreline/Fluidigm - Page
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		  	[X]	    	EXHIBIT E - RULES AND REGULATIONS
		  	[X]	    	EXHIBIT F-1 - TENANT’S PERSONAL PROPERTY
		  	[X]	    	EXHIBIT F-2 - LANDLORD’S PERSONAL PROPERTY

 1.        Lease of Premises. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to Tenant and Tenant hereby leases the
Premises from Landlord. The portions of the Project which are for the non-exclusive use of tenants of the Project are collectively referred to herein as the “Common Areas.” Landlord reserves the right to modify Common Areas,
provided that such modifications do not materially adversely affect Tenant’s use of the Premises for the Permitted Use and .provided that such modifications do not materially increase the obligations or materially decrease the rights of Tenant
under this Lease. Landlord confirms that the Premises shall be referred to as Suite 100. Landlord represents that as of April 1, 2011 none of the Premises will be leased to any parties other than Tenant. 

2.        Prior Lease; Term; Acceptance of Premises. 

(a)        Prior Lease; Term. 

(i)     Landlord and Tenant hereby acknowledge and agree that, as of the Commencement Date, (A) the
Premises West Consent Agreement together with the Oscient Space Attornment Agreement contains the complete agreement between Landlord and Tenant with respect to Premises West, (B) the Premises East Lease contains the complete agreement between
Landlord and Tenant with respect to Premises East, and (C) the Premises West Consent Agreement, the Oscient Space Attornment Agreement and the Premises East Lease are in full force and effect. 

(ii)     Tenant hereby certifies to Landlord (and its successors and assigns) that, as of the
Commencement Date, except as granted herein, (A) Tenant has no right, title, or interest in or to the Premises or the Project other than as a tenant of Premises West under the Oscient Space Attornment Agreement and as a tenant of Premises East
under the Premises East Lease, (B) Tenant has no option, right of first, refusal, right of first offer, or other right to acquire or purchase all or any portion of, or interest in, the Premises or the Project and (C) Tenant is not
currently subletting any portion of the Premises to any sublessee nor has it assigned any portion of the Oscient Sublease, the Oscient Space Attornment Agreement or the Premises East Lease to any assignee. 

(iii)     The “Term” of this Lease shall be the Base Term, as defined above in the
Basic-Lease Provisions and any Extension Term which Tenant may elect pursuant to Section 39 hereof. 

(iv)     As of the Commencement Date, the Oscient Sublease, the Oscient Space Attornment Agreement, the
Premises West Consent Agreement and the Premises East Lease shall expire and be of no further force or effect. 
 All
obligations of the parties under the Oscient Sublease, the Oscient Space Attornment Agreement, the Premises West Consent Agreement and the Premises East Lease which are by their terms intended to survive the termination of the Oscient Sublease, the
Oscient Space Attornment Agreement, the Premises West Consent Agreement and the Premises East Lease (including, without limitation, indemnity obligations and obligations concerning the condition and repair of the Premises and/or the Project) (the
“Prior Lease Obligations”) shall survive such termination of the Oscient Sublease, the Oscient Space Attornment Agreement, the Premises West Consent Agreement and the Premises East Lease for the benefit of Landlord (and its
successors and assigns). Landlord hereby reserves all rights and claims that Landlord may have against Tenant for any such Prior Lease Obligations. 
 This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises,

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agreements, understandings, and negotiations that are not contained herein including, without limitation, the Oscient Lease, the Oscient Sublease, the Oscient Space Attornment Agreement, the
Premises West Consent Agreement and the Premises East Lease. 

(b)        Acceptance of Premises. Tenant has been in possession of, and conducting
business in the Premises under the Oscient Sublease, the Oscient Space Attornment Agreement, the Premises West Consent Agreement and the Premises East Lease and intends to continue conducting business in the Premises, without interruption, from and
after the Commencement Date. Further since the Premises will not be empty and/or unoccupied at any time prior to the Commencement Date and Landlord will have no opportunity to inspect, examine, and/or audit the Premises in order to establish the
condition of the Premises as of the Commencement Date, Landlord shall have no liability for any defects in the Premises (whether latent or patent) and shall have no obligation to perform any work (except as set forth in the Work Letter) or to
refurbish, finish, or otherwise alter the Premises in order to prepare the Premises for Tenant’s use or occupancy. Except as set forth in the Work Letter, as conclusively evidenced by Tenant’s execution and delivery of this Lease, Tenant
accepts the Premises “as is”, in their condition as of the Commencement Date, without any qualifications, restrictions, or limitations, subject to all applicable Legal Requirements (as defined in Section 7 hereof). Tenant
agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project
for the conduct of Tenant’s business, and Tenant waives any implied warranty that the Premises or the Project are suitable for the Permitted Use. Landlord in executing this Lease does so in reliance upon Tenant’s representations,
warranties, acknowledgments and agreements contained herein. 
 Subject to delays resulting from Force Majeure and Tenant
Delay (as defined in the Work Letter), Landlord shall use commercially reasonable efforts to cause Landlord’s Work to be Substantially Complete (as defined in the Work Letter) on or before February 28, 2011 (“Target Completion
Date”). If Landlord fails to complete Landlord’s Work by the-Target Completion Date, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and this Lease shall not be void or voidable. If Landlord fails to
Substantially Complete Landlord’s Work by April 4, 2011 (which date shall be extended for delays resulting from Force Majeure and Tenant Delay) (such date, as so extended, the “Outside Delivery Date”), then Base Rent under
this Lease shall abate by one day for each day of delay in Substantial Completion of Landlord’s Work beyond the Outside Delivery Date. The Outside Delivery Date shall be further extended day-for-day for each day that the Execution Date extends
beyond July 19, 2010. Landlord agrees to use commercially reasonable efforts to perform Landlord’s Work in a manner which does not unreasonably interfere with Tenant’s use and enjoyment of the Premises; provided, that, Landlord shall
have no obligation to incur any additional material cost in performing Landlord’s Work. Without limiting the foregoing, Landlord agrees that it shall endeavor to schedule any utility interruptions related to the performance of Landlord’s
Work on weekends and shall endeavor to provide Tenant with at least 5 business days prior notice of any such interruption; provided, however, that notwithstanding anything to the contrary contained herein, in no event shall Landlord
have any obligation to incur any additional or overtime costs to complete Landlord’s Work. 
 Notwithstanding
anything to the contrary contained herein, for the period of 60 consecutive days after Substantial Completion of Landlord’s Work, Landlord shall, at its sole cost and expense (which shall not constitute an Operating Expense), be responsible for
any repairs that are required to be made to portions of the Building Systems serving the Premises which are newly installed as part of Landlord’s Work, unless Tenant was responsible for the cause of such repair, in which case Tenant shall pay
the cost. 
 3.        Rent. 

(a)        Base Rent.    Tenant shall pay to Landlord in
advance, without demand, abatement, deduction or set-off, monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office of Landlord for
payment of Rent set forth above, or to such other person or at such other place as Landlord may from time to time designate in writing. Payments of Base Rent for any fractional calendar month 

  7000 Shoreline/Fluidigm - Page
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shall be prorated. The obligation of Tenant to pay Base Rent and other sums to Landlord and the obligations of Landlord under this Lease are independent obligations. Tenant shall have no right at
any time to abate, reduce, or set-off any Rent (as defined in Section 5) due hereunder except for any abatement as may be expressly provided in this Lease. 

(b)        Additional Rent.  In addition to Base Rent, Tenant agrees to
pay to Landlord as additional rent (“Additional Rent”): (i) Tenant’s Share of “Operating Expenses” (as defined in Section 5), and (ii) any and all other amounts Tenant assumes or agrees to pay
under the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and conditions of this Lease to be performed
by Tenant, after any applicable notice and cure period. 

(c)        Credit.  Landlord acknowledges that Tenant has prepaid certain
base rent and additional rent for the Premises. Therefore, Landlord agrees to a one-time credit against payments of rent next coming due under this Lease in the amount of $360,373.75. 

4.        Intentionally Deleted. 

5.        Operating Expense Payments.  Landlord shall deliver to Tenant a
written estimate of Operating Expenses for each calendar year during the Term (the “Annual Estimate”), which may be revised by Landlord from time to time during such calendar year. During each month of the Term, on the same date
that Base Rent is due, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of the Annual Estimate. Payments for any fractional calendar month shall be prorated. 

The term “Operating Expenses” means all costs and expenses of any kind or description whatsoever incurred or
accrued each calendar year by. Landlord with respect to the Project (including, without duplication, Taxes (as defined in Section 9), capital repairs and improvements amortized over the lesser of 10 years and the useful life of such
capital items as reasonably determined by Landlord (“Approved Capital Expenses”), and the costs of Landlord’s third party property manager (not to exceed 3.0% of Base Rent) or, if there is no third party property manager,
administration rent in the amount of 3.0% of Base Rent), excluding only: 

(a)        the original construction costs of the Project and renovation prior to the date
of the Lease and costs of correcting defects in such original construction or renovation; 

(b)        capital expenditures for expansion of the Project and other capital
expenditures to the extent not Approved Capital Expenses; 
 (c)        any costs
incurred to remove, study, test, remediate or otherwise related to the presence of Hazardous Materials in or about the Building or the Project, which Hazardous Materials Tenant proves (i) existed prior to the Commencement Date, except to the
extent caused by or contributed to by Tenant or any Tenant Party, (ii) originated from any separately demised tenant space within the Project other than the Premises, except to the extent caused by or contributed to by Tenant or any Tenant
Party, or (iii) were not brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, the Project by Tenant or any Tenant Party; 

(d)        interest, principal payments of Mortgage (as defined in Section 27)
debts of Landlord, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured and all payments of base rent (but not taxes or operating expenses) under any ground lease or other underlying lease of all or any
portion of the Project; 
 (e)        depreciation of the Project and capital
expense reserves (except for capital improvements, the cost of which are includable in Operating Expenses); 

  7000 Shoreline/Fluidigm - Page
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 (f)        advertising, legal and space
planning expenses and leasing commissions and other costs and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants;

 (g)        legal and other expenses incurred in the negotiation or enforcement
of leases; 
 (h)        completing, fixturing, improving, renovating, painting,
redecorating or other work, which Landlord pays for or performs for other tenants within their premises, and costs of correcting defects in such work; 
 (i)        costs to be reimbursed by other tenants of the Project or Taxes to be paid directly by Tenant or other tenants of the Project, whether or not actually paid;

 (j)        salaries, wages, benefits and other compensation paid to officers
and employees of Landlord who are not assigned in whole or in part to the operation, management, maintenance or repair of the Project; 
 (k)        general organizational, administrative and overhead costs relating to maintaining Landlord’s existence, either as a corporation, partnership, or other entity,
including general corporate, legal and accounting expenses; 
 (l)        costs
(including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in
connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or mortgagees of the Building; 
 (m)        costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors or any tenant of the terms and conditions of any lease of space
in the Project or any Legal Requirement (as defined in Section 7); 

(n)        penalties, fines or interest incurred as a result of Landlord’s inability
or failure to make payment of Taxes and/or to file any tax or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(o)        overhead and profit increment paid to Landlord or to subsidiaries or affiliates
of Landlord for goods and/or services in or to the Project to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 

(p)        costs of Landlord’s charitable or political contributions, or of fine art
maintained at the Project; 
 (q)        costs in connection with services
(including electricity), items or other benefits of a type which are not standard for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project, whether
or not such other tenant or occupant is specifically charged therefor by Landlord; 

(r)        costs incurred in the sale or refinancing of the Project; 

(s)        net income taxes of Landlord or the owner of any interest in the Project,
franchise, capital stock, gift, estate or inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; 

(t)        any expenses otherwise includable within Operating Expenses to the extent
actually reimbursed by persons other than tenants of the Project under leases for space in the Project; 

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 (u)        costs incurred in connection
with the performance of alterations or modifications to the Project (other than the Premises for which Tenant shall be solely responsible for, subject to Section 7) that are required solely due to the non-compliance of the Project with
Legal Requirements applicable to the Project (other than the Premises for which Tenant shall be solely responsible for, subject to Section 7) as of the Commencement Date. 

Notwithstanding anything to the contrary contained in this Lease, Tenant’s Share of each earthquake deductible or occurrence
of uninsured earthquake damage affecting the Premises shall not exceed $7.50 per rentable square foot of the Premises (the “Initial Cap”). On June 1, 2010, and on the first day of each month thereafter, the Initial Cap shall be
reduced by $0.125 per rentable square foot of the Premises. Following earthquake damage to the Project, Tenant shall pay Tenant’s Share of any such deductible or uninsured damage in equal monthly installments amortized over the remaining
balance of the Base Term of the Lease. 
 Within 90 days after the end of each calendar year (or such longer period as may
be reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the total and Tenant’s Share of actual Operating Expenses for the previous calendar year, and
(b) the total of Tenant’s payments in respect of Operating Expenses for such year. If Tenant’s Share of actual Operating Expenses for such year exceeds Tenant’s payments of Operating Expenses for such year, the excess shall be
due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of Operating Expenses for such year exceed Tenant’s Share of actual Operating Expenses for such year Landlord shall
pay the excess to Tenant within 30 days after delivery of such Annual Statement. except that after the expiration, or earlier termination of the Term or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant
after deducting all other amounts due Landlord. 
 The Annual Statement shall be final and binding upon Tenant unless
Tenant, within 45 days after Tenant’s receipt thereof, shall contest any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 45 day period, Tenant reasonably and in good
faith questions or contests the accuracy of Landlord’s statement of Tenant’s Share of Operating Expenses, Landlord will provide Tenant with access to Landlord’s books and records relating to the operation of the Project and such
information as Landlord reasonably determines to be responsive to Tenant’s questions (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of
Tenants Share of Operating Expenses, then Tenant shall have the right to have an independent public accounting firm selected by Tenant from among the 5 largest in the United States, working pursuant to a fee arrangement other than a contingent fee
(at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld or delayed), audit and/or review the Expense Information for the year in question (the “Independent Review”). The
results of any such independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the payments actually made by Tenant with respect to Operating Expenses for the calendar year in question exceeded Tenant’s
Share of Operating Expenses for such calendar year, Landlord shall at Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the excess to Tenant within 30
days after delivery of such statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due
Landlord. If the Independent Review shows that Tenant’s payments with respect to Operating Expenses for such calendar year were less than Tenants Share of Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord
within 30 days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with respect to Operating Expenses by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the independent
Review. Tenant shall treat the results of each Independent Review as confidential and shall not disclose any information regarding such independent Review to any other tenants; provided, however, that Tenant may disclose such
information to its accountants, attorneys and real estate consultants and to governmental authorities as required by Legal Requirements and in connection with any litigation; arbitration or similar proceeding. Operating Expenses for the calendar
years in which Tenant’s obligation to share therein begins and ends shall be prorated. Notwithstanding anything set forth herein to the 

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contrary, if the Project is not at least 95% occupied on average during any year of the Term, Tenant’s Share of Operating Expenses for such year shall be computed as though the Project had
been 95% occupied on average during such year. 
 “Tenant’s Share” shall be the percentage set forth
in the Basic Lease Provisions as Tenant’s Share as reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. The rentable area of the Premises shall not be subjected to re-measurement
by either party. If Landlord has a reasonable basis for doing so, Landlord may equitably increase Tenants Share for any item of expense or cost reimbursable by Tenant that relates to a repair, replacement, or service that benefits only the Premises
or only a portion of the Project that includes the Premises or that varies with occupancy or use. Base Rent, Tenant’s Share of Operating Expenses and all other amounts payable by Tenant to Landlord hereunder are collectively referred to herein
as “Rent.” 
 6.        Security
Deposit.  Tenant shall deposit with Landlord a security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth in the Basic Lease Provisions, which
Security Deposit shall be in the form of an unconditional and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance satisfactory to Landlord, (ii) naming Landlord as beneficiary,
(iii) expressly allowing Landlord to draw upon it at any time from time to time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution satisfactory to Landlord,
and (v) redeemable by presentation of a sight draft in the state of Landlord’s choice. If Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before the stated
expiration date of any then current Letter of Credit, Landlord shall have the right to draw the full amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit. The
Security Deposit shall be held by Landlord as security for the performance of Tenant’s obligations under this Lease. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default.
Upon each occurrence of a Default (as defined in Section 20), Landlord may use all or any part of the Security Deposit to pay delinquent payments due under this Lease, future rent damages under California Civil Code Section 1951.2,
and the cost of any damage, injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or provided by law. Landlord’s right to use the Security Deposit under this Section 6 includes
the right to use the Security Deposit to pay future rent damages following the termination of this Lease pursuant to Section 21(c) below. Upon any use of all or any portion of the Security Deposit, Tenant shall pay Landlord on demand the
amount that will restore the Security Deposit to the amount set forth in the Basic Lease Provisions. Tenant hereby waives the provisions of any law, now or hereafter in force, including, without limitation, California Civil Code Section 1950.7,
which provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition,
claim those sums reasonably necessary to compensate Landlord for any other loss or damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any officer, employee, agent or invitee of Tenant. Upon bankruptcy or other
debtor-creditor proceedings against Tenant, the Security Deposit shall be deemed to be applied first to the payment of Rent and other charges due Landlord for periods prior to the filing of such proceedings. Upon any such use of all or any portion
of the Security Deposit, Tenant shall, within 5 days after demand from Landlord, restore the Security Deposit to its original amount. If Tenant shall fully perform every provision of this Lease to be performed by Tenant, the Security Deposit, or any
balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder)
within 90 days after the expiration or earlier termination of this Lease. 
 If Landlord transfers its interest in the
Project or this Lease, Landlord shall either (a) transfer any Security Deposit then held by Landlord to a person or entity assuming Landlord’s obligations under this Section 6, or (b) return to Tenant any Security Deposit
then held by Landlord and remaining after the deductions permitted herein. Upon such transfer to such transferee or the return of the Security Deposit to Tenant, Landlord shall have no further obligation with respect to the Security Deposit, and
Tenant’s right to the return of the Security Deposit shall apply solely against Landlord’s transferee. The Security Deposit is not an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default.

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Landlord’s obligation respecting the Security Deposit is that of a debtor, not a trustee, and no interest shall accrue thereon. 

Notwithstanding the foregoing, Landlord and Tenant acknowledge and agree that, as of the Commencement Date, Landlord is holding a
letter of credit from Tenant in the amount of $125,000.00 (the “Existing Letter of Credit”) which shall constitute the “Letter of Credit” for purposes of this Lease. Landlord shall cooperate with Tenant to amend the
Existing Letter of Credit to reflect the reduced amount of the Security Deposit required under this Lease. 

7.        Use.    The Premises shall be used solely for the
Permitted Use set forth in the Basic Lease Provisions, and in compliance with all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Premises, and to
the use and occupancy thereof, including, without limitation, the Americans With Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto, “ADA”) (collectively,
“Legal Requirements” and each, a “Legal Requirement”). Tenant shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by any Governmental Authority (as defined in
Section 9) having jurisdiction to be a violation of a Legal Requirement. Tenant will not use or permit the Premises to be used for any purpose or in any manner that would void Tenant’s or Landlord’s insurance, increase the
insurance risk, or cause the disallowance of any sprinkler or other credits. To Landlord’s actual knowledge, the Permitted Use will not result in the voidance of or an increase in insurance risk with respect to the insurance currently being
maintained by Landlord. Tenant shall not permit any part of the Premises to be used as a “place of public accommodation”, as defined in the ADA or any similar legal requirement. Tenant shall reimburse Landlord promptly upon demand for any
additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused by Tenant’s use and/or occupancy of the Premises. Tenant will use the Premises in a
careful, safe and proper manner and will not commit or permit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the Premises or obstruct or interfere with the rights of Landlord or other tenants or
occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful purpose. Tenant shall cause any equipment or
machinery to be installed in the Premises so as to reasonably prevent sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not place any machinery or equipment weighing 500 pounds or
more in or upon the Premises or transport or move such items through the Common Areas of the Project or in the Project elevators without the prior written consent of Landlord, which shall not be unreasonably withheld or delayed. Except as may be
provided under the Work Letter, Tenant shall not, without the prior written consent of Landlord, use the Premises in any manner which will require ventilation, air exchange, heating, gas, steam, electricity or water beyond the existing capacity of
the Project as proportionately allocated to the Premises based upon Tenant’s Share as usually furnished for the Permitted Use. 
 Landlord has received no written notice from any Governmental Authority (as defined in Section 9 below) that the Project is not in compliance with the applicable provisions of the Americans With
Disabilities Act, 42 U.S.C. § 12101, et seq. (together with regulations promulgated pursuant thereto, “ADA”). Landlord shall be responsible, at Landlord’s sole cost and expense (and not as an Operating Expense) for
the compliance of the Common Areas of the Project with the ADA as of the Commencement Date. 
 To the extent first arising
after the Commencement Date, Landlord shall, as an Operating Expense (to the extent such Legal Requirement is generally applicable to similar buildings in the area in which the Project is located) or at Tenant’s expense (to the extent such
Legal Requirement is applicable solely by reason of Tenant’s, as compared to other tenants of the Project, particular use of the Premises or any alterations or modifications made by Tenant) make any alterations or modifications to the Project
(other than the Premises) that are required by Legal Requirements, including the ADA. in addition, Landlord shall, at Landlord’s expense, make any alterations or modifications to the Premises that are required due to the non compliance of the
Premises with Legal Requirements, including the ADA, applicable to the Premises as of the Commencement Date, except to the extent such alterations or 

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modifications are required by Legal Requirements (including, without limitation, compliance of the Premises with ADA) related to Tenant’s particular use of the Premises. Notwithstanding any
other provision herein to the contrary, subject to the first two sentences of this paragraph, Tenant shall be responsible for any and all demands, claims, liabilities, losses, costs, expenses, actions, causes of action, damages or judgments, and all
reasonable expenses incurred in investigating or resisting the same (including, without limitation, reasonable attorneys’ fees, charges and disbursements and costs of suit) (collectively, “Claims”) arising out of any failure of
the Premises to comply with any Legal Requirements, and Tenant shall indemnify, defend, hold and save Landlord harmless from and against any and all Claims arising out of or in connection with any failure of the Premises to comply with any Legal
Requirement. 
 8.        Holding Over.  If, with Landlord’s
express written consent, Tenant retains possession of the Premises after the termination of the Term, (i) unless otherwise agreed in such written consent, such possession shall be subject to immediate termination by Landlord at any time,
(ii) all of the other terms and provisions of this Lease (including, without limitation, the adjustment of Base Rent pursuant to Section 4 hereof) shall remain in full force and effect (excluding any expansion or renewal option or
other similar right or option) during such holdover period, (iii) Tenant shall continue to pay Base Rent in the amount payable upon the date of the expiration or earlier termination of this Lease or such other amount as Landlord may indicate,
in Landlord’s sole and absolute discretion, in such written consent, and (iv) all other payments shall continue under the terms of this Lease. If Tenant remains in possession of the Premises after the expiration or earlier termination of
the Term without the express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Rent in effect during the last 30 days of the Term
for the first 90 days of such tenancy at sufferance and thereafter 200% of Rent in effect during the last 30 days of the Term, and (B) Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by
Tenant’s holding over, including consequential damages, No holding over by Tenant, whether with or without consent of Landlord, shall operate to extend this Lease except as otherwise expressly provided, and this Section 8 shall not
be construed as consent for Tenant to retain possession of the Premises. Acceptance by Landlord of Rent after the expiration of the Term or earlier termination of this Lease shall not result in a renewal or reinstatement of this Lease. 

9.        Taxes.  Landlord shall pay, as part of Operating Expenses, all
taxes, levies, fees, assessments and governmental charges of any kind, existing as of the Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or
other governmental authority or agency, including, without limitation, quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or measured by or
based, in whole or in part, on rent payable to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square footage, assessed value or other
measure or evaluation of any kind of the Premises or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises or the Project, including parking, or (iv) assessed or imposed by, or at
the direction of, or resulting from Legal Requirements, or interpretations thereof, promulgated by any Governmental Authority, or (v) imposed as a license or other fee, charge, tax, or assessment on Landlord’s business or occupation of
leasing space in the Project. Landlord may contest by appropriate legal proceedings the amount, validity, or application of any Taxes or liens securing Taxes. Notwithstanding anything to the contrary herein, Landlord shall only charge Tenant for
such assessments existing as of the Commencement Date as if those assessments were paid by Landlord over the longest possible term which Landlord is permitted to pay for the applicable assessments without additional charge other than interest, if
any, provided under the terms of the underlying assessments. Notwithstanding anything to the contrary contained in this Lease, Taxes shall not include any net income taxes, estate taxes or inheritance taxes imposed on Landlord except to the extent
such net income taxes are in substitution for any Taxes payable hereunder, or any late penalties, interest or fines imposed due to Landlord’s failure to pay any Taxes prior to delinquency. If any such Tax is levied or assessed directly against
Tenant, then Tenant shall be responsible for and shall pay the same at such times and in such manner as the taxing authority shall require. Tenant shall pay, prior to delinquency, any and all Taxes levied or assessed against any personal property or
trade fixtures placed by Tenant in the Premises, 

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whether levied or assessed against Landlord or Tenant, If any Taxes on Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property, or if the
assessed valuation of the Project is increased by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real property so as to become a part thereof, higher than
the base valuation on which Landlord from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed valuation shall be
binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due from Tenant to Landlord immediately upon demand. 

10.        Parking.  Subject to all matters of record, Force Majeure, a
Taking (as defined in Section 10 below) and the exercise by Landlord of its rights hereunder, Tenant shall have the right, in common with other tenants of the Project pro rata in accordance with the rentable area of the Premises and the
rentable areas of the Project occupied by such other tenants, to park in those areas designated for non-reserved parking, subject in each case to Landlord’s rules and regulations, As of the Commencement Date, Tenant’s pro rata share of
parking equates to 2.8 parking spaces per 1,000 RSF of the Premises. Landlord may allocate parking spaces among Tenant and other tenants in the Project pro rata as described above if Landlord determines that such parking facilities are becoming
crowded. Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including other tenants of the Project. 
 11.        Utilities, Services.  Landlord shall provide, subject to the terms of this Section 11, water, electricity, heat, light, power,
telephone, sewer, and other utilities (including gas and fire sprinklers to the extent the Project is plumbed for such services, deionized water, compressed air and house vacuum system), refuse and trash collection and janitorial services
(collectively, “Utilities”). Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer charges
or other similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar charges thereon. Landlord may cause, at Landlord’s expense, any Utilities to be separately metered
or charged directly to Tenant by the provider. Tenant shall pay directly to the Utility provider, prior to delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant shall pay,
as part of Operating Expenses, its share of all charges for jointly metered Utilities based upon consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever other than Landlord’s willful
misconduct, shall result in eviction, or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use. 

Landlord’s sole obligation for either providing emergency generators or providing emergency back-up power to Tenant shall be
(i) to provide emergency generators with not less than the stated capacity of the emergency generators located in the Building as of the Commencement Date, and (ii) to contract with a third party to maintain the emergency generators as per
the manufacturer’s standard maintenance guidelines, Landlord shall have no obligation to provide Tenant with operational emergency generators or back-up power or to supervise, oversee or confirm that the third party maintaining the emergency
generators is maintaining the generators as per the manufacturer’s standard guidelines or otherwise. During any period of replacement, repair or maintenance of the emergency generators when the emergency generators are net operational,
including any delays thereto due to the inability to obtain parts or replacement equipment, Landlord shall have no obligation to provide Tenant with an alternative back-up generator or generators or alternative sources of back-up power. Tenant
expressly acknowledges, and agrees that Landlord does not guaranty that such emergency generators will be operational at all times or that emergency power will be available to the Premises when needed. 

12.        Alterations and Tenant’s Property.  Any alterations,
additions, or improvements made to the Premises by or on behalf of Tenant, including additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but excluding installation, removal or realignment of furniture systems
(other than removal of furniture systems owned or paid for by Landlord) not involving any 

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modifications to the structure or connections (other than by ordinary plugs or jacks) to Building Systems (as defined in Section 13) (“Alterations”) shall be subject
to Landlord’s prior written consent, which may be given or withheld in Landlord’s sole discretion if any such Alteration affects the structure or Building Systems, but which shall otherwise not be unreasonably withheld or delayed. Tenant
may construct nonstructural Alterations in the Premises without Landlord’s prior approval if the aggregate cost of all such work in any 12 month period does not exceed $50,000 (a “Notice-Only Alteration”), provided Tenant
notifies Landlord in writing of such intended Notice-Only Alteration, and such notice shall be accompanied by plans, specifications, work contracts and such other information concerning the nature and cost of the Notice-Only Alteration as may be
reasonably requested by Landlord, which notice and accompanying materials shall be delivered to Landlord not less than 15 business days in advance of any proposed construction. If Landlord approves any Alterations, Landlord may impose such
conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s reasonable discretion. Any request for approval shall be in writing, delivered not less than
15 business days in advance of any proposed construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the alterations as may be reasonably requested by
Landlord, including the identities and mailing addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord
shall have no duty to ensure that such plans and specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole- cost and expense, all Alterations to comply with insurance requirements and with Legal
Requirements and shall implement at its sole cost and expense any alteration or modification required by Legal Requirements as a result of any Alterations. Tenant shall pay to Landlord, as Additional Rent, on demand an amount equal to 3% of all
charges incurred by Tenant or its contractors or agents in connection with any Alteration to cover Landlord’s overhead and expenses for plan review, coordination, scheduling and supervision. Before Tenant begins any Alteration, Landlord may
post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant or
its contractors, delays caused by such work, or inadequate cleanup. 
 Tenant shall furnish security or make other
arrangements reasonably satisfactory to Landlord to assure payment for the completion of all Alterations work free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for
workers’ compensation and other coverage in amounts and from an insurance company satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations,
Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) ”as built” plans
for any such Alteration. 
 Except for Removable Installations (as hereinafter defined), all Installations (as hereinafter
defined) shall be and shall remain the property of Landlord following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term, and shall remain upon and be surrendered with the Premises as a part
thereof. Notwithstanding the foregoing, Landlord shall if requested by Tenant, at the time its approval of any such Installation is requested, notify Tenant if Landlord requires that Tenant remove such Installation upon the expiration or earlier
termination of the Term, in which event Tenant shall remove such installation in accordance with the immediately succeeding sentence. Upon the expiration or earlier termination of the Term, Tenant shall remove (i) all wires, cables or similar
equipment which Tenant has installed in the Premises or in the risers or plenums of the Building, (ii) any Installations for which Landlord has given Tenant notice of removal in accordance with the immediately preceding sentence, and
(iii) all of Tenant’s Property (as hereinafter defined), and Tenant shall restore and repair any damage caused by or occasioned as a result of such removal, including, without limitation, capping off all such connections behind the walls
of the Premises and repairing any holes. Notwithstanding anything to the contrary contained herein, Tenant shall have no obligation to remove Landlord’s Work. During any restoration period beyond the expiration or earlier termination of the
Term, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. If Landlord is requested by Tenant or any lender, lessor or other person 

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or entity claiming an interest in any of Tenant’ Property to waive any lien Landlord may have against any of Tenant’s Property, and Landlord consents to such waiver, then Landlord shall
be entitled to be paid as administrative rent a fee of $1,000 per occurrence for its time and effort in preparing and negotiating such a waiver of lien. 
 For purposes of this Lease, (x) “Removable Installations” means any items listed on Exhibit F-1 attached hereto and any items agreed by Landlord in writing to be included on
Exhibit F-1 in the future, (y) ”Tenant’s Property” means Removable Installations and, other than Installations, any personal property or equipment of Tenant that may be removed without material damage to the
Premises, and (z) “Installations” means all property of any kind paid for with the Ti Fund, all Alterations, all fixtures, and all partitions, hardware, built-in machinery, built-in casework and cabinets and other similar
additions, equipment, property and improvements built into the Premises so as to become an integral part of the Premises,, including, without limitation, fume hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms,
walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment, autoclaves, chillers, built-in plumbing, electrical and mechanical equipment and systems, and any power generator and transfer switch. Notwithstanding the
foregoing, the parties acknowledge and agree that the items set forth on Exhibit F-2 (“Landlord’s Property”) are Landlord’s property and shall not be removed by Tenant from the Building. Tenant shall have the
right during the Term to use any of Landlord’s Property that is located in the Premises as of the Execution Date. Tenant shall accept any of such Landlord’s Property in its “as is” condition and shall return any of such
Landlord’s Property to Landlord upon the expiration or earlier termination of this Lease in the same condition as received, ordinary wear and tear excepted. 

13.        Landlord’s Repairs.  Landlord, as an Operating Expense
(except to the extent the cost thereof is expressly excluded from Operating Expenses pursuant to Section 5 hereof), shall maintain all of the structural, exterior, parking and other Common Areas of the Project, including HVAC, plumbing,
fire sprinklers, elevators and all other building systems serving the Premises and other portions of the Project (“Building Systems”), in good repair, reasonable wear and tear and uninsured losses and damages (unless such losses or
damages would have been insured losses or expenses if the insurance Landlord is required to maintain hereunder had been obtained) caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (collectively,
“Tenant Parties”) excluded. Subject to the provisions of the penultimate paragraph of Section 17, losses and damages caused by Tenant or any Tenant Party shall be repaired by Landlord, at Tenant’s sole cost and
expense, to the extent not covered by insurance Landlord is required to maintain hereunder (or to the extent such losses or damages would have been covered by insurance Landlord is required to maintain hereunder if such insurance had been
..maintained). Landlord reserves the right to stop Building Systems services when necessary (i) by reason of accident or emergency, or (ii) for planned repairs, alterations or improvements, which are, in the judgment of Landlord, desirable
or necessary to be made, until said repairs, alterations or improvements shall have been completed, provided Landlord shall use commercially reasonable efforts to minimize interference with Tenant’s Permitted Use of the Premises. Landlord shall
have no responsibility or liability for failure to supply Building Systems services during any such period of interruption; provided, however, that Landlord shall, except in case of emergency, make a commercially reasonable effort to
give Tenant 24 hours advance notice of any planned stoppage of Building Systems services for routine maintenance, repairs, alterations or improvements and shall in all events use commercially reasonable efforts to perform any repairs in a manner
that will minimize interference with Tenant’s use of the Premises. Tenant shall promptly give Landlord written notice of any repair required by Landlord pursuant to this Section, after which Landlord shall make a commercially reasonable effort
to effect such repair. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for such repairs or
maintenance as provided in this Lease. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at Landlord’s expense and agrees that the parties’ respective rights with respect to such matters
shall be solely as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of damage or destruction shall be controlled by Section 18. 

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 14.        Tenant’s
Repairs.  Except as otherwise set forth in Section 13 hereof, Tenant, at its expense, shall repair, replace and maintain in good condition all portions of the Premises, including, without limitation, entries, doors,
ceilings, interior windows, interior walls, and the interior side of demising walls; provided, however, that Landlord shall be responsible, as part of Operating Expenses, for repairs, replacements and maintenance that could constitute
capital expenditures and repairs whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give Tenant notice of such failure. If Tenant fails to commence
cure of such failure within 10 days of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant within 10 days after demand therefor; provided,
however, that if such failure by Tenant creates or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure from Tenant. Subject to
Sections 17 and 18, Tenant shall bear the full uninsured cost of any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the Premises.

 15.        Mechanic’s Liens.  Tenant shall discharge, by
bond or otherwise, any mechanic’s lien filed against the Premises or against the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant within 10 days after the filing thereof, at Tenant’s
sole cost and shall otherwise keep the Premises and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have
the right, but not the obligation, to pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant
shall lease or finance the acquisition of office equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code Financing
Statement filed as a matter of public record by any lessor or creditor of Tenant will upon its face or by exhibit thereto indicate that such Financing Statement is applicable only to removable personal property of Tenant located within the Premises.
In no event shall the address of the Project be furnished on the statement without qualifying language as to applicability of the lien only to removable personal property, located in an identified suite held by Tenant. 

16.        Indemnification.  Tenant hereby indemnifies and agrees to
defend, save and hold Landlord harmless from and against any and all Claims for injury or death to persons or damage to property occurring, within or about the Premises, arising directly or indirectly out of use or occupancy of the Premises or a
breach or default by Tenant in the performance of any of its obligations hereunder, except to the extent caused by the willful misconduct or negligence of Landlord or the default by Landlord in the performance of its obligations under this Lease.
Landlord shall .not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without limitation, loss of records kept within the Premises). Tenant further waives any and all Claims for injury to Tenant’s
business or loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any act, omission or neglect of any tenant in
the Project or of any other third party. 

17.        Insurance.  Landlord shall maintain all risk property and, if
applicable, sprinkler damage insurance covering the full replacement cost of the Project or such lesser coverage amount as Landlord may elect provided such coverage amount is not less than 90% of such full replacement cost. Landlord shall
further procure and maintain commercial general liability insurance with a single loss limit of not less than $2,000,000 for bodily injury and property damage with respect to the Project. Landlord may, but is not obligated to, maintain such other
insurance and additional coverages as it may deem necessary, including, but not limited to, flood, environmental hazard and earthquake, loss or failure of building equipment, errors and omissions, rental loss during the period of repair or
rebuilding, workers’ compensation insurance and fidelity bonds for employees employed to perform services and insurance for any improvements installed by Tenant or which are in addition to the standard improvements customarily furnished by
Landlord without regard to whether or not such are made a part of the Project. All such insurance shall be included as part of the Operating Expenses. The Project may be included in a blanket policy (in which case the cost of such insurance
allocable to the Project will be determined by 

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Landlord based upon the insurer’s cost calculations). Tenant shall also reimburse Landlord for any increased premiums or additional insurance which Landlord reasonably deems necessary as a
result of Tenant’s use of the Premises. 
 Tenant, at its sole cost and expense, shall maintain during the Term: all
risk property insurance with business interruption and extra expense coverage, covering the full replacement cost of all property and improvements installed or placed in the Premises by Tenant at Tenant’s expense; workers’ compensation
insurance with no less than the minimum limits required by law; employer’s liability insurance with such limits as required by law; and commercial general liability insurance, with a minimum limit of not less than $2,000,000 per occurrence for
bodily injury and property damage with respect to the Premises. The commercial general liability insurance policy shall name Alexandria Real Estate Equities, Inc., and Landlord, its officers, directors, employees, managers, agents, invitees and
contractors (collectively, “Landlord Parties”), as additional insureds; insure on an occurrence and not a claims-made basis; be issued by insurance companies which have a rating of not less than policyholder rating of A and
financial category rating of at least Class X in “Best’s Insurance Guide”; shall not be cancelable for nonpayment of premium unless 10 days prior written notice shall have been given to Landlord; contain a hostile fire
endorsement and a contractual liability endorsement; and provide primary coverage to Landlord (any policy issued to Landlord providing duplicate or similar coverage shall be deemed excess over Tenant’s policies). Copies of such policies (if
requested by Landlord), or certificates of insurance showing the limits of coverage required hereunder and showing Landlord as an additional insured, along with reasonable evidence of the payment of premiums for the applicable period, shall be
delivered to Landlord by Tenant upon commencement of the Term and upon each renewal of said insurance. Tenant’s policy may be a “blanket policy” with an aggregate per location endorsement which specifically provides that the amount of
insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least 5 days prior to the expiration of such policies, furnish Landlord with renewal certificates. 

In each instance where insurance is to name Landlord as an additional insured, Tenant shall upon written request of Landlord also
designate and furnish certificates so evidencing Landlord as additional insured to: (i) any lender of Landlord holding a security interest in the Project or any portion thereof, (ii) the landlord under any lease wherein Landlord is tenant
of the real property on which the Project is located, if the interest of Landlord is or stall become that of a tenant under a ground or other underlying lease rather than that of a fee owner, and/or (iii) any management company retained by
Landlord to manage the Project. 
 The property insurance obtained by Landlord and Tenant shall include a waiver of
subrogation by the insurers and all rights based upon an assignment from its insured, against Landlord or Tenant, and their respective officers, directors, employees, managers, agents, invitees and contractors (“Related Parties”),
in connection with any loss or damage thereby insured against. Notwithstanding anything to the contrary contained in this Lease, neither party nor its respective Related Parties shall be liable to the other for loss or damage caused by any risk
insured against under property insurance required to be maintained hereunder regardless of the negligence of the party to the Lease receiving the benefit of the waiver, and each party waives any claims against the other party, and its respective
Related Parties, for such loss or damage. The failure of a party to insure its property shall not void this waiver. Landlord and its respective Related Parties shall not be liable for, and Tenant hereby waives all claims against such parties for,
business interruption and losses occasioned thereby sustained by Tenant or any person claiming through Tenant resulting from any accident or occurrence in or upon the Premises or the Project from any cause whatsoever. If the foregoing waivers shall
contravene any law with respect to exculpatory agreements, the liability of Landlord or Tenant shall be deemed not released but shall be secondary to the other’s insurer. 

Landlord may require insurance policy limits to be raised to conform with requirements of Landlord’s lender and/or to bring
coverage limits to levels then being generally required of new tenants within the Project; provided, however, that the increased amount of coverage is consistent with coverage amounts then being required by institutional owners of
similar projects with tenants occupying similar size premises in the geographical area in which the Project is located. 

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18.        Restoration.  If, at any time during the Term, the Project or
the Premises are damaged or destroyed by a fire or other casualty, Landlord shall notify Tenant within 60 days after discovery of such damage as to the amount of time Landlord reasonably estimates it will take to restore the Project or the Premises,
as applicable (the “Restoration Period”). If the Restoration Period is estimated to exceed 9 months (the “Maximum Restoration Period”), Landlord may, in such notice, elect to terminate this Lease as of the date that
is 75 days after the date of discovery of such damage or destruction: provided, however, that notwithstanding Landlord’s election to restore, Tenant may elect to terminate this Lease by written notice to Landlord delivered within
5 business days of receipt of notice from Landlord estimating a Restoration Period for the Premises longer than the Maximum Restoration Period. Unless either Landlord or Tenant so elects to terminate this Lease, Landlord shall, subject to receipt of
sufficient insurance proceeds (with any deductible to be treated as an Operating Expense subject to the provisions of Section 5), promptly restore the Premises (excluding the improvements installed by Tenant or by Landlord and paid for
by Tenant), subject to delays arising from the collection of insurance proceeds, from Force Majeure events or as needed to obtain any license, clearance or other authorization of any kind required to enter into and restore the Premises issued by any
Governmental Authority having jurisdiction over the use, storage, handling, treatment, generation, release, disposal, removal or remediation of Hazardous Materials (as defined in Section 30) in, on or about the Premises (collectively
referred to herein as “Hazardous Materials Clearances”); provided, however, that if repair or restoration of the Premises is not substantially complete as of the end of the Maximum Restoration Period or, if longer, the
Restoration Period, Landlord may, in its sole and absolute discretion, elect not to proceed with such repair and restoration, or Tenant may by written notice to Landlord delivered within 5 business days of the expiration of the Maximum Restoration
Period or, if longer, the Restoration Period, elect to terminate this Lease, in which event Landlord shall be relieved of its obligation to make such repairs or restoration and this Lease shall terminate as of the date that is 75 days after the
later of: (i) discovery of such damage or destruction, or (ii) the date all required Hazardous Materials. Clearances are obtained, Out Landlord shall retain any Rent paid and the right to any Rent payable by Tenant prior to such election
by Landlord or Tenant. Notwithstanding the foregoing, if a portion of the Project not including the Premises is damaged, Landlord may not terminate this Lease on the basis that the Restoration Period will exceed the Maximum Restoration Period if
Landlord elects to merely repair the damage rather than redevelop or improve the Project as a whole, and Landlord actually commences construction of the repair of such damage. The Restoration Period and the Maximum Restoration Period shall not be
extended by Force Majeure. In the event that the Lease terminates pursuant to the provisions of this Section 18 as a result of an earthquake, Tenant shall not be required to pay any deductibles as part of Operating Expenses in connection
with such earthquake. 
 Tenant may, at Tenant’s option, promptly re-enter the Premises and commence doing business
in accordance with this Lease upon Landlord’s completion of all repairs or restoration required to be done, by Landlord pursuant to this Section 18; provided, however, that Tenant shall nonetheless (and even if Tenant
does not re-enter the Premises) continue to be responsible for all of its obligations under this Lease. Notwithstanding the foregoing, Landlord may terminate this Lease if the Premises are damaged during the last 1 year of the Term and Landlord
reasonably estimates that it will take more than 2 months to repair such damage, or if insurance proceeds are not available for such restoration. Rent shall be abated from the date of the casualty until the Premises are repaired and restored, in the
proportion which the area of the Premises, if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant with other space in the Project during the period of repair that is suitable for the temporary
conduct of Tenant’s business. Such abatement shall be the sole remedy of Tenant, and except as provided in this Section 18, Tenant waives any right to terminate the Lease by reason of damage or casualty loss. 

The provisions of this Lease, including this Section 18, constitute an express agreement between Landlord and Tenant
with respect to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any
damage or destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section 18 sets forth their entire understanding and agreement with respect to such matters.

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 19.       Condemnation.  If
the whole or any material part of the Premises or the Project is taken for any public or quasi-public use under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in lieu thereof (a
“Taking” or “Taken”), and the Taking would in Landlord’s reasonable judgment, either prevent or materially interfere with Tenant’s use of the Premises or materially interfere with or impair Landlord’s
ownership or operation of the Project, then upon written notice by Landlord this Lease shall terminate and Rent shall be apportioned as of said date. If part of the Premises shall be Taken, and this Lease is not terminated as provided above,
Landlord shall promptly restore the Premises and the Project as nearly as is commercially reasonable under the circumstances to their condition prior to such partial Taking and the rentable square footage of the Building, the rentable square footage
of the Premises, Tenant’s Share of Operating Expenses and the Rent payable hereunder during the unexpired Term shall be reduced to such extent as may be fair and reasonable under the circumstances. Upon any such Taking, Landlord shall be
entitled, to receive the entire price or award from any such Taking, without any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award. Tenant shall have the right, to the extent that same shall not
diminish Landlord’s award, to make a separate claim against the condemning authority (but not Landlord) for such compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures,
if a separate award for such items is made to Tenant. Tenant hereby waives any and all rights it might otherwise have pursuant to any provision of state law to terminate this Lease upon a partial Taking of the Premises or the Project. 

20.       Events of Default.  Each of the following events shall be a default
(“Default”) by Tenant under this Lease: 
 (a)        Payment
Defaults.  Tenant shall fail to pay any installment of Rent or any other payment hereunder when due; provided, however, that Tenant’s first failure to pay any installment of Rent or any other payment hereunder
otherwise due in any 12 calendar month period shall not constitute a Default unless such payment is not made within 5 days after written notice from Landlord to Tenant and Tenant agrees that such notice shall be in lieu of and not in addition to, or
shall be deemed to be, any notice required by law. 

(b)        Insurance.  Any insurance required to be maintained by Tenant
pursuant to this Lease shall be canceled or terminated or shall expire or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance at least
20 days before the expiration of the current coverage, 

(c)        Abandonment.  Tenant shall abandon the Premises. 

(d)        Improper Transfer.  Tenant shall assign, sublease or otherwise
transfer or attempt to transfer all or any portion of Tenant’s interest in this Lease or the Premises except as expressly permitted herein, or Tenant’s interest in this Lease shall be attached, executed upon, or otherwise judicially seized
and such action is not released within 90 days of the action. 

(e)        Liens.  Tenant shall fail to discharge or otherwise obtain the
release of any lien placed upon the Premises in violation of this Lease within 10 days after any such lien is filed against the Premises. 
 (f)        Insolvency Events.  Tenant or any guarantor or surety of Tenant’s obligations hereunder shall: (A) make a general assignment for the
benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment,
liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for all or of any substantial part of its property (collectively a “Proceeding for
Relief”), (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor, or surety is an individual) or be dissolved
or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

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 (g)        Estoppel Certificate or
Subordination Agreement.  Tenant fails to execute any document required from Tenant under Sections 23 or 27 within 5 days after a second notice requesting such document. 

(h)        Other Defaults.  Tenant shall fail to comply with any
provision of this Lease other than those specifically referred to in this Section 20, and, except as otherwise expressly provided herein, such failure shall continue for a period of 10 days after written notice thereof from Landlord to
Tenant. 
 Any notice given under Section 20(h) hereof shall: (i) specify the alleged default,
(ii) demand that Tenant cure such default, (iii) be in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this
Lease unless Landlord elects otherwise in such notice; provided that if the nature of Tenants default pursuant to Section 20(h) is such that it cannot be cured by the payment of money and reasonably requires more than 10 days to
cure, then Tenant shall not be deemed to be in default if Tenant commences such cure within said 10 day period and thereafter diligently prosecutes the same to completion; provided, however, that such cure shall be completed no later
than 30 days from the date of Landlord’s notice. 
 21.       Landlord’s
Remedies. 
 (a)        Payment By Landlord; interest.  Upon
a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation of Tenant hereunder, make such payment or perform such act. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums
were paid or incurred, at the annual rate equal to 12% per annum or the highest rate permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing herein shall be
construed to create or impose a duty on Landlord to mitigate any damages resulting from Tenant’s Default hereunder. 

(b)        Late Payment Rent.  Late payment by Tenant to Landlord of Rent
and other sums due will cause Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting charges
and late charges which may be imposed on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay to
Landlord an additional sum equal to 6% of the overdue Rent as a late charge. Notwithstanding the foregoing, before assessing a late charge the first time in any calendar year, Landlord shall provide Tenant written notice of the delinquency and will
waive the right if Tenant pays such delinquency within 5 days thereafter. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to the late
charge, Rent not paid when due shall bear interest at the Default Rate from the 5th day after the date due until paid. 

(c)        Remedies.  Upon the occurrence of a Default, Landlord, at its
option, without further notice or demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each and all of which shall be
cumulative and nonexclusive, without any notice or demand whatsoever. 
 (i)     Terminate this
Lease, or at Landlord’s option, Tenants right to possession only, in which event Tenant shall immediately surrender the Premises to Landlord, and if Tenant fails to do so, Landlord may, without prejudice to any other remedy which it may have
for possession or arrearages in rent, enter upon and take possession of the Premises and expel or remove Tenant and any other person who may be occupying the Premises or any part thereof, without being liable for prosecution or any claim for damages
therefor; 
 (ii)     Upon any termination of this Lease, whether pursuant to the foregoing
Section 21(c)(i) or otherwise. Landlord may recover from Tenant the following: 

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 (A)        The worth at the time of award
of any unpaid rent which has been earned at the time of such termination; plus 

(B)        The worth at the time of award of the amount by which the unpaid rent which
would have been earned after termination until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(C)        The worth at the time of award of the amount by which the unpaid rent for the
balance of the Term after the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 
 (D)        Any other amount necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or
which in the ordinary course of things would be likely to result therefrom, specifically including, but not limited to, brokerage commissions and advertising expenses incurred, expenses of remodeling the Premises or any portion thereof for a new
tenant, whether for the same or a different use, and any special concessions made to obtain a new tenant; and 

(E)        At Landlord’s election, such other amounts in addition to or in lieu of
the foregoing as may be permitted from time to time by applicable law. 
 The term “rent” as used in this
Section 21 shall be deemed to be and to mean all sums of every nature required to be paid by Tenant pursuant to the terms of this Lease, whether to Landlord or to others. As used in Sections 21(c)(ii)(A) and (B), above, the
“worth at the time of award” shall be computed by allowing interest at the Default Rate. As used in Section 21(c)(ii)(C) above, the “worth at the time of award” shall be computed by discounting such
amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus 1%. 

(iii)     Landlord may continue this Lease in effect after Tenant’s Default and recover rent as it
becomes due (Landlord and Tenant hereby agreeing that Tenant has the right to sublet or assign hereunder, subject only to reasonable limitations). Accordingly, if Landlord does not elect to terminate this Lease following a Default by Tenant,
Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies hereunder, including the right to recover all Rent as it becomes due. 

(iv)     Whether or not Landlord elects to terminate this Lease following a Default by Tenant, Landlord
shall have the right to terminate any and all subleases, licenses, concessions or other consensual arrangements for possession entered into by Tenant and affecting the Premises or may, in Landlord’s sole discretion, succeed to Tenant’s
interest in such subleases, licenses, concessions or arrangements. Upon Landlord’s election to succeed to Tenant’s interest in any such subleases, licenses, concessions or arrangements, Tenant shall, as of the date of notice by Landlord of
such election, have no further right to or interest in the rent or other consideration receivable thereunder. 

(v)     independent of the exercise of any other remedy of Landlord hereunder or under applicable law,
Landlord may conduct an environmental test of the Premises as generally described in Section 30(d) hereof, at Tenant’s expense. 
 (d)        Effect of Exercise.    Exercise by Landlord of any remedies hereunder or otherwise available shall not be deemed to be an acceptance of
surrender of the Premises and/or a termination of this Lease by Landlord, it being understood that such surrender and/or termination can be effected only by the express written agreement of Landlord and Tenant. Any law, usage, or custom to the
contrary notwithstanding, Landlord shall have the right at all times to enforce the provisions of this Lease in strict accordance with the terms hereof; and the failure of Landlord at any time to enforce its rights under this Lease strictly in
accordance with same shall not be construed as having created a custom in any way or manner contrary to the specific terms, provisions, and covenants of this Lease or as having 

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modified the same and shall not be deemed a waiver of Landlord’s right to enforce one or more of its rights in connection with any subsequent default. A receipt by Landlord of Rent or other
payment with knowledge of the breach of any covenant hereof shall not be deemed a waiver of such breach, and no waiver by Landlord of any provision of this Lease shall be deemed to have been made unless expressed in writing and signed by Landlord.
Following a Default by Tenant under this Lease and Tenants failure to cure such Default within the applicable cure period prescribed in this Lease, to the greatest extent permitted by law, Tenant waives the service of notice of Landlord’s
intention to re-enter, re-take or otherwise obtain possession of the Premises as provided in any statute, or to institute legal proceedings to that end, and also waives all right of redemption in case Tenant shall be dispossessed by a judgment or by
warrant of any court or judge. Any reletting of the Premises or any portion thereof shall be on such terms and conditions as Landlord in its sole discretion may determine. Landlord shall not be liable for, nor shall Tenant’s obligations
hereunder be diminished because of, Landlord’s failure to relet the Premises or collect rent due in respect of such reletting or otherwise to mitigate any damages arising by reason of Tenant’s Default. 

22.        Assignment and Subletting. 

(a)        General Prohibition. Without Landlord’s prior written consent
subject to and on the conditions described in this Section 22, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any -part thereof or mortgage, pledge, or
hypothecate its leasehold interest or grant any concession or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. If Tenant is a corporation, partnership or limited liability company, the shares or
other ownership interests thereof which are not actively traded upon a stock exchange or in the over-the-counter market, a transfer or series of transfers whereby 49% or more of the issued and outstanding shares or other ownership interests of such
corporation are, or voting control is, transferred (but excepting transfers upon deaths of individual-owners) from a person or persons or entity or entities which were owners thereof at time of execution of this Lease to persons or entities who were
not owners of shares or other ownership interests of the corporation, partnership or limited liability company at time of execution of this Lease, shall be deemed an assignment of this Lease requiring the consent of Landlord as provided in this
Section 22. Notwithstanding the foregoing, (a) any public offering of shares or other ownership interest in Tenant shall not be deemed an assignment and (b) Tenant shall have the right to obtain financing from investors
(including venture capital funding and corporate partners) which results in a change in control of Tenant without such change of control constituting an assignment under this Section 22 requiring Landlord consent, provided that
(i) Tenant notifies Landlord in writing of the financing at least 5 business days prior to the closing of the financing, and (ii) provided that in no event shall such financing result in a change in use of the Premises from the
use-contemplated by Tenant at the commencement of the Term. 

(b)        Permitted Transfers.  if Tenant desires to assign, sublease,
hypothecate or otherwise transfer this Lease or sublet the Premises other than pursuant to a Permitted Assignment (as defined below), then at least 15 business days, but not more than 45 business days, before the date Tenant desires the assignment
or sublease to be effective (the “Assignment Date”), Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the proposed use of
the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all
material terms and conditions of the proposed assignment or sublease, including a copy of any proposed assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration
whether to grant its consent. Landlord may, by giving written notice to Tenant within 15 business days after receipt of the Assignment Notice: (i) grant such consent, (ii) refuse such consent, in its reasonable discretion, or
(iii) with respect to an assignment of this Lease or sublease of substantially all of the Premises, terminate this Lease as of the Assignment Date (an “Assignment Termination”). Among other reasons, it shall be reasonable for
Landlord to withhold its consent in any of these circumstances: (1) the proposed assignee or subtenant is a governmental agency; (2) in Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant
would entail any alterations that would lessen the value of the leasehold improvements in the 

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Premises, or would require increased services by Landlord; (3) in Landlord’s reasonable judgment, the proposed assignee or subtenant is engaged in areas of scientific research or other
business concerns that are controversial; (4) in Landlord’s reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment or sublease;
(5) in Landlord’s reasonable judgment, the proposed assignee or subtenant is inconsistent with the desired tenant-mix or quality of other tenancies in the Project or is inconsistent with the type and quality of the nature of the Building;
(6) Landlord has received from any prior landlord to the proposed assignee or subtenant a negative report concerning such prior landlord’s experience with .the proposed assignee or subtenant; (7) Landlord has experienced previous
defaults by or is in litigation with the proposed assignee or subtenant; (8) the use of the Premises by the proposed assignee or subtenant will violate any applicable Legal Requirements; (9) the proposed assignee or subtenant is an entity
with whom Landlord has agreed to a letter of intent to lease space in the Project; or (10) the proposed assignment or sublease is prohibited by Landlord’s lender. If Landlord delivers notice of its election to exercise an Assignment
Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 business days after Landlord’s notice electing to exercise the Assignment Termination, If Tenant withdraws such
Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date. No failure of Landlord to
exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed assignment, sublease or other transfer. Tenant shall pay to Landlord
a fee equal to One Thousand Five Hundred Dollars ($1,500) in connection with its consideration of any Assignment Notice and/or its preparation or review of any consent documents. 

Notwithstanding the foregoing, (i) Landlord’s consent to an assignment of this Lease or a subletting of any portion of
the Premises to any entity controlling, controlled by or under common control with Tenant shall not be required, provided that Landlord shall have the right to approve the form of any such sublease or assignment, which consent shall not be
unreasonably withheld or delayed, and (ii) Tenant shall have the right to undergo a deemed assignment due to change in control or assign this Lease, upon 30 days prior written notice to Landlord but without obtaining Landlord’s prior
written consent, to a corporation or other entity which is a successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of
Tenant provided that (A) such merger or consolidation, or such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (B) the net worth (as
determined in accordance with generally accepted accounting principles (“GAAP”)) of the assignee is not less than the net worth (as determined in accordance with GAAP) of Tenant as of the date of Tenant’s most current quarterly
or annual financial statements, and (C) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment (a “Permitted Assignment”).
Notwithstanding anything in this Section 22(b) to the contrary, Landlord shall not have the right to elect an Assignment Termination in connection with a Permitted Assignment. 

(c)        Additional Conditions.  As a condition to any such assignment
or subletting, whether or not Landlord’s consent is required, Landlord may require: 

(i)        that any assignee or subtenant agree, in writing at the time of such assignment
or subletting, that if Landlord gives such party notice that Tenant is in default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any
liability except to credit such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason: provided, however, in
no event shall Landlord or its successors or assigns be obligated to accept such attornment; and 

(ii)        A list of Hazardous Materials, certified by the proposed assignee or sublessee
to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all 

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documents relating to such use, storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior
to the proposed assignment or subletting, including, without limitation: permits; approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project
(provided, said installation of tanks shall only be permitted after Landlord has given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents
required by any and all federal, state and local Governmental Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however,
to provide Landlord with any portion(s) of the such documents containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 

(d)        No Release of Tenant, Sharing of Excess
Rents.    Notwithstanding any assignment or subletting, Tenant and any guarantor or surety of Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for the payment of
Rent and for compliance with all of Tenants other obligations under this Lease. Except with respect to a Permitted Assignment, if the Rent due and payable by a sublessee or assignee (or a combination of the rental payable under such sublease or
assignment plus any bonus or other consideration therefor or incident thereto in any form attributable to the assignment or sublease) exceeds the sum of the rental payable under this Lease, (excluding however, any Rent payable under this Section and
actual and reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms of any such sublease) (“Excess Rent”), then Tenant shall be bound and obligated to pay
Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the Premises or any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for
Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward
Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have the right to collect such rent. 
 (e)        No Waiver.  The consent by Landlord to an assignment or subletting shall not relieve Tenant or any assignees of this Lease or any sublessees of
the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and primary liability under the Lease. The acceptance of Rent hereunder, or the
acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of this Lease or a consent to any subletting, assignment or other transfer of
the Premises. 
 (f)        Prior Conduct of Proposed Transferee.
Notwithstanding any other provision of this Section 22, if (i) the proposed assignee or sublessee of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial action in connection with
Hazardous Materials contaminating a property, where the contamination resulted from such party’s action or use of the property in question, (ii) the proposed assignee or sublessee is subject to an enforcement order issued by any
Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental
Authority), or (iii) because of the existence of a pre-existing environmental condition in the vicinity of or underlying the Project, the risk that Landlord would be targeted as a responsible party in connection with the remediation of such
pre-existing environmental condition would be materially increased or exacerbated by the proposed use of Hazardous Materials by such proposed assignee or sublessee, Landlord shall have the absolute right to refuse to consent to any assignment or
subletting to any such party. 
 23.        Estoppel
Certificate.    Tenant shall, within 10 business days of written notice from Landlord, execute, acknowledge and deliver a statement in writing in any form reasonably requested by a proposed lender or purchaser,
(i) certifying that this Lease is unmodified and in full force and effect (or, if modified, stating the nature of such modification and certifying that this Lease as so modified is in full

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force and effect) and the dates to which the rental and other charges are paid in advance, if any, (ii) acknowledging that there are not any uncured defaults on the part of Landlord
hereunder, or specifying such defaults if any are claimed, and (iii) setting forth such further information with respect to the status of this Lease or the Premises as may be requested thereon. Any such statement may be relied upon by any
prospective purchaser or encumbrancer of all or any portion of the real property of which the Premises are a part. Tenant’s failure to deliver such statement within such time shall, at the option of Landlord, constitute a Default under this
Lease after the expiration of the notice and cure period set forth in Section 20(g), and, in any event, shall be conclusive upon Tenant that the Lease is in full force and effect and without modification except as may be represented by
Landlord in any certificate prepared by Landlord and delivered to Tenant for execution. 

24.        Quiet Enjoyment.  So long as Tenant is not in Default under
this Lease, Tenant shall, subject to the terms of this Lease, at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person claiming by, through or under Landlord. 

25.        Prorations.  All prorations required or permitted to be made
hereunder shall be made on the basis of a 360 day year and 30 day months. 

26.        Rules and Regulations.  Tenant shall, at all times during the
Term and any extension thereof, comply with all reasonable rules and regulations at any time or from time to time established by. Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as
Exhibit E. If there is any conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Landlord shall not have any liability or obligation for the breach of any
rules or regulations by other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 
 27.        Subordination.  This Lease and Tenant’s interest and rights hereunder are hereby made and shall be subject and subordinate at all times to
the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements, renewals, modifications, consolidations, refinancing, assignments and extensions thereof, without the necessity
of any further instrument or act on the part of Tenant; provided, however that so long as there is no Default hereunder, Tenant’s right to possession of the Premises shall not be disturbed by the Holder of any such Mortgage.
Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to any such Holder. Tenant agrees upon demand to execute, acknowledge and deliver such instruments, confirming such subordination, and such instruments of attornment as
shall be requested by any such Holder, provided any such instruments contain appropriate non-disturbance provisions assuring Tenant’s quiet enjoyment of the Premises as set forth in this Section 27 and Section 24 hereof.
Notwithstanding the foregoing, any such Holder may at any time subordinate its Mortgage to this Lease, without Tenant’s consent, by notice in writing to Tenant, and thereupon this Lease shall be deemed prior to such Mortgage without regard to
their respective dates of execution, delivery or recording and in that event such Holder shall have the same rights with respect to this Lease as though this Lease had been executed prior to the execution, delivery and recording of such Mortgage and
had been assigned to such Holder. The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of trust, security assignments and any other encumbrances, and any reference to the “Holder” of a
Mortgage shall be deemed to include the beneficiary under a deed of trust. 

28.        Surrender.  Upon the expiration of the Term or earlier
termination of Tenant’s right of possession, Tenant shall surrender to Landlord (i) Premises West in the same condition as existed on March 1, 2004 (i.e. the commencement date under the Oscient Sublease), subject to any Alterations or
Installations permitted by Landlord to remain in Premises West (including Landlord’s Work and any alterations existing on the Commencement Date, which may remain in the Premises), free of Hazardous Materials brought upon, kept, used, stored,
handled, treated, generated in, or released or disposed of from, Premises West on or after March 1, 2004 by any person other than a Landlord Party (collectively, “Premises West Tenant HazMat Operations”) and released of all
Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty loss and condemnation covered by Sections 18 and 19 excepted and (ii) Premises East in the same conditions as existed on December 8, 2001
(i.e. the 

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commencement date under the Premises East Lease), subject to any Alterations or Installations permitted by Landlord to remain in Premises East (including Landlord’s Work and any alterations
existing on the Commencement Date, which may remain in the Premises), free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, Premises East on or after December 8, 2001 by
any person other than a Landlord Party (collectively, “Premises East Tenant HazMat Operations” and together with Premises West Tenant HazMat operations, “Tenant HazMat Operations”) and released of all Hazardous
Materials Clearances, broom clean, ordinary wear and tear and casualty loss and condemnation covered by Sections 18 and 19 excepted. At least 3 months prior to the surrender of the Premises, Tenant shall deliver to Landlord a
narrative description of the actions proposed (or required by any Governmental Authority) to be taken by Tenant in order to surrender the Premises (including any Installations permitted by Landlord to remain in the Premises) at the expiration or
earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a current
listing of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to the Premises, and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the
Premises, and shall be subject to the review and approval of Landlord’s environmental consultant, such approval not to be unreasonably withheld or delayed. In connection with the review and approval of the Surrender Plan, upon the request of
Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the
approved Surrender Plan shall have been satisfactorily completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and
perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the Lease; free from any residual impact from Tenant HazMat Operations.
Tenant shall reimburse Landlord, as Additional Rent, for the actual reasonable out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify
satisfactory completion of the same, which cost shall not exceed $2,500. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the
Premises to third parties. 
 If Tenant shall fail to prepare or submit a Surrender Plan approved by Landlord, or if
Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about the Premises, Landlord shall
have the right to take such actions as Landlord may deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of which actions shall be reimbursed
by Tenant as Additional Rent, without regard to the limitation set forth in the first paragraph of this Section 28, Tenant shall immediately return to Landlord all keys and/or access cards to parking, the Project, restrooms or all or any
portion of the Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of replacing such lost access card or key or the cost of
reprogramming the access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so removed by Tenant as permitted or required herein shall be
deemed abandoned and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from Landlord’s retention and/or disposition of such property. All
obligations of Tenant hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Section 30 hereof, shall survive the expiration or earlier termination of the Term, including, without
limitation, indemnity obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 
 29.        Waiver of Jury Trial.  TO THE EXTENT PERMITTED BY LAW, TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A JURY PARTICIPATE IN
RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER 

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INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS RELATED HERETO. 

30.        Environmental Requirements. 

(a)        Prohibition/Compliance/Indemnity.  Tenant shall not cause or
permit any Hazardous Materials (as hereinafter defined) to be brought upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises or the Project in violation of applicable Environmental
Requirements (as hereinafter defined) by Tenant or any Tenant Party. If Tenant breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises results in contamination of the Premises, the Project
or any adjacent property or if contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises by
anyone other than Landlord and Landlord’s employees, agents and contractors otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord, its officers, directors, employees, agents and
contractors harmless from any and all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages
(including, without limitation, punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without
limitation, attorneys’, consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether
or not based upon personal injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise as a
result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of site conditions or any cleanup, treatment, remedial, removal, or restoration work required
by any federal, state or local Governmental Authority because of Hazardous Materials, present in the air, soil or ground water above, on, or under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials on the
Premises, the Project or any adjacent property caused by or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent property, Tenant shall promptly take all actions at its sole expense and in
accordance with applicable Environmental Requirements as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that Landlord’s approval of such
action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises or the Project. Notwithstanding anything to the
contrary contained in Section 28 or this Section 30, Tenant shall not be responsible for or have any liability to Landlord, and the indemnification and hold harmless obligation set forth in this paragraph shall not apply to
Hazardous Materials in the Premises, which Hazardous Materials Tenant proves to Landlord’s reasonable satisfaction (i) existed prior to March 1, 2004 (i.e. the commencement date under the Oscient Sublease), as to the Premises West,
and December 8, 2001 (i.e., the commencement date under the Premises East Lease), as to the Premises East, (ii) originated from any separately demised tenant space within the Project other than the Premises, (iii) were not brought
upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, the Project by Tenant or any Tenant Party, or (iv) migrated from outside the Premises into the Premises, unless in each case, to the extent the presence
of such Hazardous Materials (x) is the result of a breach by Tenant of any of its obligations under this Lease, or (y) was caused, contributed to or exacerbated by Tenant or any Tenant Party. 

(b)        Business.  Landlord acknowledges that it is not the intent of
this Section 30 to prohibit Tenant from using the Premises for the Permitted Use. Tenant may operate its business according to prudent industry practices so long as the use or presence of Hazardous Materials is strictly and properly
monitored according to all then applicable Environmental Requirements. As a material inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord prior to September 15,
2010 a list identifying each type of Hazardous Materials to be brought upon, kept, used, stored, handled, treated, generated on, or released or disposed 

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of from, the Premises and setting forth any and all governmental approvals or permits required in connection with the presence, use, storage, handling, treatment, generation, release or disposal
of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord an updated Hazardous Materials List at least once a year, Tenant shall deliver to Landlord true and correct copies of
the following documents (the “Haz Mat Documents”) relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to September 15, 2010, or if unavailable at that time, concurrent
with the receipt from or submission to a Governmental Authority: permits: approvals; reports and correspondence; storage and management plans, notice of violations of any Legal Requirements; plans relating to the installation of any storage tanks to
be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has given Tenant its written consent to do sc, which consent may be withheld in Landlord’s sole and absolute discretion);
all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks; and a Surrender Plan (to the extent
surrender in accordance with Section 28 cannot be accomplished in 3 months). Tenant is not required, however, to provide Landlord with any portion(s) of the Haz Mat Documents containing information of a proprietary nature which, in
and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. It is not the intent of this Section to provide Landlord with information which could be detrimental to Tenant’s business should such information
become possessed by Tenant’s competitors. 
 (c)        Tenant
Representation and Warranty.  Tenant hereby represents and warrants to Landlord that (i) neither Tenant nor any of its legal predecessors has been required by any prior landlord, lender or Governmental Authority at any time to
take remedial action in connection with Hazardous Materials contaminating a property which contamination was permitted by Tenant of such predecessor or resulted from Tenant’s or such predecessor’s action or use of the property in question,
and- (ii) Tenant is not subject to any enforcement order issued by any Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any
order related to the failure to make a required reporting to any Governmental’ Authority). If Landlord determines that this representation and warranty was not true as of the date of this lease, Landlord shall have the right to terminate this
Lease in Landlord’s sole and absolute discretion. 

(d)        Testing.  In accordance with the provisions of
Section 32, Landlord shall have the right to conduct annual tests of the Premises to determine whether any contamination of the Premises or the Project has occurred as a result of Tenant’s use. Tenant shall be required to pay the
cost of such annual test of the Premises if there is a violation of this Section 30 or if contamination for which Tenant is responsible under this Section 30 is identified; provided, however, that if Tenant
conducts its own tests of the Premises using third party contractors and test procedures acceptable to Landlord which tests are certified to Landlord, Landlord shall accept such tests in lieu of the annual tests to be paid for by Tenant. In
addition, at any time, and from time to time, prior to the expiration or earlier termination of the Term, Landlord shall have the right to conduct appropriate tests of the Premises and the Project to determine if contamination has occurred as a
result of Tenant’s use of the Premises, in connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such non-proprietary information concerning the use of Hazardous Materials in or about the
Premises by Tenant or any Tenant Party. If contamination has occurred for which Tenant is liable under this Section 30, Tenant shall pay all costs to conduct such tests. If no such contamination is found, Landlord shall pay the costs of
such tests (which shall not constitute an Operating Expense), Landlord shall provide Tenant with a copy of all third party, non-confidential reports and tests of the Premises made by or on behalf of Landlord during the Term without representation or
warranty and subject to a confidentiality agreement. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate any environmental conditions identified by such testing in accordance with all Environmental Requirements.
Landlord’s receipt of or satisfaction with any environmental assessment in no way waives any rights which Landlord may have against Tenant. 
 (e)        Underground Tanks.  If underground or other storage tanks storing Hazardous Materials located on the Premises or the Project are used by Tenant or
are hereafter placed on the Premises or the Project by Tenant, Tenant shall install, use, monitor, operate, maintain, upgrade and 

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manage such storage tanks, maintain appropriate records, obtain and maintain appropriate insurance, implement reporting procedures, properly close any underground storage tanks, and take or cause
to be taken all other actions necessary or required under applicable state and federal Legal Requirements, as such now exists or may hereafter be adopted or amended in connection with the installation, use, maintenance, management, operation,
upgrading and closure of such storage tanks. 
 (f)        Tenant’s
Obligations.  Tenant’s obligations under this Section 30 shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier termination of this Lease required by
Tenant or Landlord to complete the removal from the Premises of any Hazardous Materials (including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises and the completion of the approved
Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 

(g)        Definitions.  As used herein, the term “Environmental
Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to health, safety, or environmental
conditions on, under, or about the Premises or the Project, or the environment, including without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource Conservation and Recovery Act; and
all state and local counterparts thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and includes any substance, material, waste, pollutant, or contaminant
listed or defined as hazardous or toxic, or regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof,
natural gas liquids, liquefied natural gas, or synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of
Tenant’s “facility” and the “owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or produced therefrom.

 31.        Tenant’s Remedies/Limitation of
Liability.  Landlord shall not be in default hereunder unless Landlord fails to perform any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will, due to the
nature of the obligation, require a period of time in excess of 30 days, then after such period of time as is reasonably necessary). Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage
covering the Premises and to any landlord of any lease of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the
Project by power of sale or a judicial action if such should prove necessary to effect a cure; provided Landlord shall have furnished to Tenant in writing the names and addresses of all such persons who are to receive such notices. All
obligations of Landlord hereunder shall be construed as covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

All obligations of Landlord under this Lease will be binding upon Landlord only during the period of its ownership of the Premises
and not thereafter. The term “Landlord” in this Lease shall mean only the owner for the time being of the Premises. Upon the transfer by such owner of its interest in the Premises, such owner shall thereupon be released and
discharged from all obligations of Landlord thereafter accruing, but such obligations shall be binding during the Term upon each new owner for the duration of such owner’s ownership. 

32.        Inspection and Access.  Landlord and its agents,
representatives, and contractors may enter the Premises at any reasonable time to inspect the Premises and to make such repairs as may be required or permitted pursuant to this Lease. Landlord and Landlord’s representatives may enter the
Premises during business hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for the purpose of effecting any such repairs,
inspecting the Premises, showing the Premises to prospective 

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purchasers and, during the last year of the Term, to prospective tenants; provided, however, Landlord may show the Premises to prospective tenants only in the last 9 months of the
Term. Landlord may erect a suitable sign on the Premises stating the Premises are available to let or that the Project is available for sale. Landlord may grant easements, make public dedications, designate Common Areas and create restrictions on or
about the Premises, provided that no such easement, dedication, designation or restriction materially, adversely affects Tenant’s use or occupancy of the Premises for the Permitted Use. At Landlord’s request, Tenant shall execute such
instruments as may be necessary for such easements, dedications or restrictions. Tenant shall at all times, except in the case of emergencies, have the right to escort Landlord or its agents, representatives, contractors or guests while the same are
in the Premises, provided such escort does not materially and adversely affect Landlord’s access rights hereunder. 

33.        Security.  Tenant acknowledges and agrees that security devices
and services, if any, while intended to deter crime may not in given instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises. Tenant agrees that Landlord shall not be
liable to Tenant for, and Tenant waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises or any other breach of security with
respect to the Premises. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the Premises and/or the Project. Tenant shall
at Tenant’s cost obtain -insurance coverage to the extent Tenant desires protection against such criminal acts. 

34.        Force Majeure.  Landlord shall not be responsible or liable for
delays in the performance of its obligations hereunder when caused by, related to, or arising out of acts of God, sinkholes or subsidence, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather, national, regional, or local
disasters, calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance, governmental restrictions, orders,
limitations, regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or other casualty, and other causes
or events beyond the reasonable control of Landlord (“Force Majeure”). 

35.        Brokers.  Landlord and Tenant each represents and warrants that
it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with this transaction and that no Broker brought about this transaction, other than Cresa Partners. Landlord and Tenant each hereby agree
to indemnify and hold the other harmless from and against any claims by any Broker, other than the broker, if any named in this Section 35, claiming a commission or other form of compensation by virtue of having dealt with Tenant or
Landlord, as applicable, with regard to this leasing transaction. Landlord shall be responsible for all fees of Broker arising out of the execution of this Lease in accordance with the terms of a separate written agreement between Broker and
Landlord. 
 36.        Limitation on Landlord’s
Liability.  NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT TO THE CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON
ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC
EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE
NO PERSONAL RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD
HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF 

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AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED
AGAINST LANDLORD IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF
LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT THEREFROM. 

37.        Severability.  If any clause or provision of this Lease is
illegal, invalid or unenforceable under present or future laws, then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. It is also the intention of the parties to this Lease
that in lieu of each clause or provision of this Lease that is illegal, invalid or unenforceable, there be added, as a part of this Lease, a clause or provision as similar in effect to such illegal, invalid or unenforceable clause or provision as
shall be legal, valid and enforceable. 
 38.        Signs; Exterior
Appearance.  Tenant shall not, without the prior written consent of Landlord, which may be granted or withheld in Landlord’s sole discretion: (i) attach any awnings, exterior lights, decorations, balloons, flags, pennants,
banners, painting or other projection to any outside wall of the Project, (ii) use any curtains, blinds, shades or screens other than Landlord’s standard window coverings, (iii) coat or otherwise sunscreen the interior or exterior of
any windows, (iv) place any bottles, parcels, or other articles on the window sills, (v) place any equipment, furniture or other items of personal property on any exterior balcony, or (vi) paint, affix or exhibit on any part of the
Premises or the Project any signs, notices, window or door lettering, placards, decorations, or advertising media of any type which can be viewed from the exterior of the Premises. Interior signs on doors and the directory tablet shall be inscribed,
painted or affixed for Tenant by Landlord at the sole cost and expense of Tenant, and shall be of a size, color and type acceptable to Landlord. Nothing may be placed on the exterior of corridor walls or corridor doors other than Landlord’s
standard lettering. The directory tablet shall be provided exclusively for the display of the name and location of tenants. Tenant shall be entitled to retain all of its signage existing at the Project as of the Commencement Date. 

39.        Right to Extend Term.  Tenant shall have the right to extend
the Term of the Lease upon the following terms and conditions: 

(a)        Extension Rights.  Tenant shall have 1 right (an
“Extension Right”) to extend the term of this Lease with respect to the entire Premises subject to this Lease at the time the Extension Right is exercised for 3 years (an “Extension Term”) on the same terms and
conditions as this Lease (other than with respect to Base Rent and Tenant’s Share) by giving Landlord written notice of its election to exercise the Extension Right at least 9 months prior, and no earlier than 12 months prior, to the expiration
of the Base Term of the Lease. 
 Notwithstanding anything to the contrary contained in this Lease, if Tenant exercise its
Extension Right hereunder, commencing on May 1, 2015, Tenant’s Share of each earthquake deductible or occurrence of uninsured earthquake damage affecting the Premises shall not exceed $7.50 per rentable square foot of the Premises (the
“Extension Cap”). On June 1, 2015, and on the first day of each month thereafter, the Extension Cap shall be reduced by $0.125 per rentable square foot of the Premises. Following earthquake damage to the Project during the
Extension Term, Tenant shall pay Tenant’s Share of any such deductible or uninsured damage in equal monthly installments amortized over the balance of the Term of the Lease. 

Upon the commencement of the Extension Term, Base Rent shall be payable at the Market Rate (as defined below). Base Rent shall
thereafter be adjusted on each annual anniversary of the commencement of such Extension Term by a percentage as determined by Landlord and agreed to by Tenant at the time the Market Rate is determined. As used herein, “Market Rate”
shall mean the then market rental rate as determined by Landlord and agreed to by Tenant. 

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 If, on or before the date which is 120 days prior to the expiration of the Base
Term of this Lease, Tenant has not agreed with Landlord’s determination of the Market Rate and the rent escalations during the Extension Term after negotiating in good faith, Tenant may by written notice to Landlord not later than 120 days
prior to the expiration of the Base Term of this Lease, or the expiration of any then effective Extension Term, elect arbitration as described in Section 39(b) below. If Tenant does not elect such arbitration, Tenant shall be deemed to
have waived any right to extend, or further extend, the Term of the Lease and all of the remaining Extension Rights shall terminate. 
 (b)        Arbitration. 

(i)        Within 10 days of Tenant’s notice to Landlord of its election to arbitrate
Market Rate and escalations, each party shall deliver to the other a proposal containing the Market Rate and escalations that the submitting party believes to be correct (“Extension Proposal”). If either party fails to timely submit
an Extension Proposal, the other party’s submitted proposal shall determine the Base Rent and escalations for the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after delivery of
the last Extension Proposal and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate and escalations. If Landlord and Tenant are unable to agree upon a single Arbitrator, then each shall,
by written notice delivered to the other within 10 days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal shall determine the Base Rent
and any escalations for the Extension Term. The 2 Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If the 2 Arbitrators so selected cannot agree on the selection of the third
Arbitrator within the time above specified, then either party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the Premises are
located, upon 10 days prior written notice to the other party of such intent. 

(ii)        The decision of the Arbitrator(s) shall be made within 30 days after the
appointment of a single Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and
binding upon the parties. Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate and
escalations are not determined by the first day of the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by 3% until such determination is
made. After the determination of the Market Rate and escalations, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Base Rate and escalations for the
Extension Term. 
 (iii)        An “Arbitrator” shall be any
person appointed by or on behalf of either party or appointed pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal
of improved office and high tech industrial real estate in the South San Francisco, California area, or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of
high tech or life sciences space in the South San Francisco, California area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects
impartial and disinterested. 
 (c)        Rights Personal.  The
Extension Right is personal to Tenant and is not assignable without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s
interest in the Lease, except that it may be assigned in connection with any Permitted Assignment of this Lease. 

(d)        Exceptions.    Notwithstanding anything set forth
above to the contrary, the Extension Right shall not be in effect and Tenant may not exercise the Extension Right: 

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 (i)        during any period of time that
Tenant is in Default under any provision of this Lease; or 
 (ii)        if
Tenant has been in Default under any provision of this Lease 3 or more times, whether or not the Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the
Defaults are cured. 
 (e)        No Extensions.  The period of
time within which the Extension Right may be exercised shall not be extended or enlarged by reason of Tenants inability to exercise the Extension Right. 
 (f)        Termination.  The Extension Right shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of the
Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term, (i) Tenant fails to timely cure any default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from
the date of the exercise of the Extension Right to the date of the commencement of the Extension Term, whether or not such Defaults are cured. 
 40.        Give-Back.  On the later of (i) February 28, 2011 or (ii) the date that Landlord Substantially Completes Landlord’s Work (the
later of such dates, the “Give-Back Date”), this Lease shall terminate solely as it relates to the portion of Premises West containing approximately 8,268 RSF and shown on Exhibit A-3 attached hereto (the
“Give-Back Spaces”). Tenant shall surrender the Give-Back Space to Landlord in the condition required under this Lease on or before the Give-Back Date and thereafter, the parties shall have no further obligations under this Lease
with respect to the Give-Back Space except for any obligations intended to survive the termination of this Lease. Tenant shall be entitled to surrender the Give-Back Space without removing or restoring any alterations currently in the Give-Back
Space and without improving the condition of the Give-Back Space from its condition as of the Commencement Date. Notwithstanding anything to the contrary herein, commencing one (1) day after the Give-Back Date, the “Premises” shall
not include the Give-Back Space and the rentable area of the Premises shall be 29,228 RSF thereafter. If Tenant fails to surrender the Give-Back Space to Landlord in the condition required by this Section 40 on or before the Give-Back
Date, then such failure shall be deemed a holdover of Tenant in the Give-Back Space as set forth in Section 8 above; provided, that, in addition to Base Rent, Tenant shall pay holdover rent applicable to the Give-Back Space equal to
$20,350.45 per month. 
 41.        Shared Area. 

(a)        License.  Landlord hereby grants to Tenant, and Tenant hereby
accepts, a non-exclusive license (“License”) to use the gym on the second floor of the Building and the common break room on the first floor of the Building being more particularly described on Exhibit D (collectively,
the “Shared Area”), subject to the terms and provisions of this Section 40, during normal business hours. 
 (b)        Use.  Tenant shall exercise its rights under this Section 40 and use the Shared Area in a manner that complies with all applicable
Legal Requirements and any and all reasonable rules and regulations which may be adopted by Landlord from time to time for the use of the Shared Area by all parties entitled to use the same and which shall be applied to all users of the Shared Area
in a non-discriminatory manner. 
 Tenant shall use the Shared Area in a manner that will not interfere with the rights of
any other tenants, other licensees or Landlord’s service providers, Landlord assumes no responsibility for enforcing Tenant’s rights or for protecting the Shared Area from interference or use from any person including, without limitation,
other tenants or licensees of the Project. Landlord may terminate the License granted to Tenant hereunder at any time during the Term for Tenants failure to comply, with the terms of this Section 41 or any rules and regulations adopted
by Landlord with respect to the Shared Area, which failure continues for more than 3 business days after Landlord delivers written notice thereof to Tenant. 

  7000 Shoreline/Fluidigm - Page
 32
 
  

 Tenant’s use of the Shared Area shall be at Tenant’s risk and Landlord
shall have no responsibility or liability to Tenant for Tenants use thereof. Landlord shall maintain the Shared Area in substantially the condition existing as of the Commencement Date; provided, that, Landlord reserves the right to relocate within
the Building or make minor changes, alterations and improvements to the Shared Area, so long as the Shared Area remains in substantially the same condition existing as of the Commencement Date. 

42.        Miscellaneous. 

(a)        Notices.  All notices or other communications between the
parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt it delivered by reputable overnight guaranty courier, addressed and sent
to the parties at their addresses set forth above. Landlord and Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 

(b)        Joint and Several Liability.  If and when included within the
term “Tenant,” as used in this instrument, there is more than one person or entity, each shall be jointly and severally liable for the obligations of Tenant. 

(c)        Financial Information.  Tenant shall furnish Landlord with
true and complete copies of (i) Tenants most recent audited annual financial statements within 180 days of the end of each of Tenant’s fiscal years during the Term, (ii) Tenant’s most recent unaudited quarterly financial
statements within 45 days of the end of each of Tenant’s first three fiscal quarters of each of Tenant’s fiscal years during the Term, (iii) any other financial information or summaries that Tenant typically provides to its lenders.
Notwithstanding the foregoing, in no event shall Tenant be required to provide any of the foregoing financial information to Landlord if Tenant does not otherwise prepare it (or cause it to be prepared) for its own purposes. 

(d)        Recordation.  Neither this Lease nor a memorandum of lease
shall be filed by or on behalf of Tenant in any public record. Landlord may prepare and file, and upon request by Landlord Tenant will execute, a memorandum of lease. 

(e)        Interpretation.  The normal rule of construction to the effect
that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. Words of any gender used in this Lease shall be held and construed to include any
other gender, and words in the singular number shall be held to include the plural, unless the context otherwise requires. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise describe the scope or
intent of this Lease, or any provision hereof, or in any way affect the interpretation of this Lease. 

(f)        Not Binding Until Executed.  The submission by Landlord to
Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party until execution of this Lease by both parties. 

(g)        Limitations on Interest.  it is expressly the intent of
Landlord and Tenant at all times to comply with applicable law governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest
called for under this Lease, or contracted for, charged, taken, reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on
the applicable obligation (or, if the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without
the necessity of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 

  7000 Shoreline/Fluidigm - Page
 33
 
  

 (h)        Choice of
Law.  Construction and interpretation of this Lease shall be governed by the internal laws of the state in which the Premises are located, excluding any principles of conflicts of laws. 

(i)        Time.  Time is of the essence as to the performance of Tenants
obligations under this Lease. 
 (j)        OFAC.  Tenant, and
all beneficial owners of Tenant, are currently (a) in compliance with and shall at all times during the Term of this Lease remain in compliance with the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S.
Department of Treasury and any statute, executive order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the term of this Lease be listed on, the Specially Designated
Nationals and Blocked Persons List maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with
whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

(k)        Incorporation by Reference.  All exhibits and addenda attached
hereto are hereby incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control. 

(l)        No Accord and Satisfaction.  No payment by Tenant or receipt
by Landlord of a lesser amount than the monthly installment of Base Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or letter
accompanying a check for payment of any Base Rent or Additional Rent be an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any other
remedy provided in this Lease. 
 (m)        Hazardous
Activities.  Notwithstanding any other provision of this Lease, Landlord, for itself and its employees, agents and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which,
pursuant to Tenant’s routine safety guidelines, practices or custom or prudent industry practices, require any form of protective clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are
acceptable to Landlord, in Landlord’s reasonable discretion, for all such repairs and services, and Landlord shall, to the extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to
reflect that Landlord is not providing such repairs or services to Tenant. 

(n)        Project Specific Requirements.  Tenant acknowledges that the
use and operation of the Project are governed by, among other things, CC&Rs and Environmental CC&Rs, and Tenant acknowledges having reviewed copies of the same. Tenant agrees to comply with all of the terms of the CC&Rs and Environmental
CC&Rs which are applicable to tenants of the Project including, without limitation, maintaining the insurance required under the Environmental CC&Rs. As used herein, (i) ”CC&Rs” mean that certain Amended and
Restated Declaration of Covenants, Conditions and Restrictions for Sierra Point recorded in the Official Records of San Mateo County on October 23, 1998, as amended, and (ii) ”Environmental CC&Rs” mean that certain
First Amended and Restated Declaration of Covenants, Conditions and Environmental Restrictions Relating to Environmental Compliance for Sierra Point, recorded in the Official Records of San Mateo County on October 20, 1999 as instrument
No.1999-176058. 

 7000 Shoreline/Fluidigm 
  

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and
year first above written. 
  

					
	TENANT:
	
	 FLUIDIGM CORPORATION,
 a
Delaware corporation

		
	By:	 	 /s/ Gajus V. Worthington

		
	Title:	 	 CEO

	
	LANDLORD:
	
	 ARE-SAN FRANCISCO NO. 17, LLC,

a Delaware limited liability company

	
	By: ALEXANDIA REAL ESTATE EQUITIES, L.P.,
	a Delaware limited partnership, its managing member
			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	its general partner
		
	 By:
	 	 /s/ Eric S. Johnson

		
		 	 Eric S. Johnson, Vice President,
	 Title:
	 	  Real Estate Legal Affairs

 7000 Shoreline/Fluidigm 
  

 EXHIBIT A-1 TO LEASE 
 DESCRIPTION OF PREMISES WEST 

 

 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT A-2 TO LEASE 
 DESCRIPTION OF PREMISES EAST 

 

 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT A-3 TO LEASE 
 DESCRIPTION OF GIVE-BACK SPACE 

 

 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT B TO LEASE 
 DESCRIPTION OF PROJECT 
 CITY OF SOUTH SAN FRANCISCO 

PARCEL 1: 
 PARCEL C, AS SHOWN ON THAT
CERTAIN MAP ENTITLED, “PARCEL MAP 98-044 LANDS OF SIERRA POINT, LLC, CITY OF SOUTH SAN FRANCISCO”, FILED IN THE OFFICE OF THE COUNTY RECORDER OF SAN MATEO COUNTY, STATE OF CALIFORNIA, ON AUGUST 6, 1999, IN BOOK 71 OF PARCEL MAPS, AT
PAGE(S) 71 AND 72. 
 PARCEL 2: 

THOSE CERTAIN ACCESS EASEMENTS AS DESCRIBED IN THE FIRST AMENDMENT TO AMENDED AND RESTATED DECLARATION OF COVENANTS, CONDITIONS AND RESTRICTIONS
FOR SIERRA POINT RECORDED AUGUST 6, 1999, AS DOCUMENT NO, 1999-134787, AND RERECORDED OCTOBER 20, 1999, AS DOCUMENT NO. 1999-176057. 
 ASSESSOR’S
PARCEL NO. 015-010-570 JOINT PLANT NO. 015-001-010-02.04A 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT C TO LEASE 

WORK LETTER 

THIS WORK LETTER (this “Work Letter”) is made and entered into by and between ARE-SAN FRANCISCO NO. 17,
LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation (“Tenant”), and is attached to and made a part of this Lease. Any initially capitalized terms used
but not defined herein shall have the meanings given them in the Lease. 

1.        General Requirements. 

(a)        Tenant’s Authorized Representative.    Tenant
designates Vikram Jog and Nanci Salvucci (either such individual acting alone, “Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond
to or act upon any request, approval, inquiry or other communication (“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant
may change either Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the
performance of Landlord’s Work (as hereinafter defined), 

(b)        Landlord’s Authorized
Representative.    Landlord designates Greg Gehlen, Radika Bunton, Todd Miller and Catie Paton (either such individual acting alone, “Landlord’s Representative”) as the only persons authorized to act for
Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication from or on behalf of Landlord in connection with this Work Letter unless such Communication is in
writing from Landlord’s Representative. Landlord may change any Landlord’s Representative at any time upon not less than 5 business days advance written notice to Tenant. Landlord’s Representatives shall be the sole persons authorized
to direct Landlord’s contractors in the performance of Landlord’s Work. 

(c)        Architects, Consultants and
Contractors.      Landlord and Tenant hereby acknowledge and agree that: (i) the general contractor and any subcontractors for the Tenant improvements shall be selected by Landlord, subject to Tenant’s
approval, which approval shall not be unreasonably withheld, conditioned or delayed, and (ii) Dowler Gruman Architects shall be the architect (the “TI Architect”) for the Tenant Improvements. If requested by Tenant, Landlord
shall cause at least three (3) general contractors to bid for construction of the Tenant Improvements. All bids will be opened together with Landlord selecting the general contractor to construct the Tenant Improvements, subject to the approval
of Tenant not to be unreasonably withheld, conditioned or delayed. 

2.        Tenant Improvements. 

(a)        Tenant Improvements Defined.    As used herein,
“Tenant Improvements” shall mean all improvements to the Project of a fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below, including laboratory casework, fume hoods,
lighting and flooring. Landlord and Tenant acknowledge and agree that the Tenant Improvements shall include fully demising and securing the Give-Back Space from the remainder of the Premises as shown on the Space Plan which work shall be performed
along with and as part of the remainder of the Tenant Improvements at Tenant’s sole cost and expense. Other than Landlord’s Work (as defined in Section 3(a) below, Landlord shall not have any obligation whatsoever with respect
to the finishing of the Premises for Tenant’s use and occupancy. 

(b)        Tenant’s Space Plans. Landlord and Tenant acknowledge and agree
that the plan prepared by the TI Architect attached to this Work Letter as Schedule 1 (the “Space Plan”) has been 

 7000 Shoreline/Fluidigm 
  

 
approved by both Landlord and Tenant. Landlord and Tenant further acknowledge and agree that any changes to the Space Plan requested by Tenant shall constitute a Change Request the cost of which
changes shall be paid for by Tenant. 
 (c)        Working Drawings.
Landlord shall cause the TI Architect to prepare and deliver to Tenant for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings
shall be prepared substantially in accordance with the Space Plan. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Tenant shall deliver its written
comments on the TI Construction Drawings to Landlord not later than 5 business days after Tenant’s receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the Space Plan without
submitting a Change Request. Landlord and the TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments. Any disputes in connection
with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent with the Space Plan, Tenant shall approve the TI Construction Drawings submitted by
Landlord, unless Tenant submits a Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord shall not materially modify the TI Construction Drawings except as may be reasonably required in connection
with the issuance of the TI Permit (as defined in Section 3(b) below), 

(d)        Approval and Completion. Upon any dispute regarding the design of the
Tenant Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts
reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all costs and expenses resulting from any such decision by Tenant shall be
payable out of the TI Fund (as defined in Section 5(d) below), and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building systems. Any changes to the TI Construction
Drawings following Landlord’s and Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 
 3.        Performance of Landlord’s Work. 
 (a)        Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall mean the work of designing, permitting and constructing
the Tenant Improvements. 
 (b)        Commencement and Permitting.
Landlord shall promptly commence construction of the Tenant Improvements upon obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings
approved by Tenant. The cost of obtaining the TI Permit shall be payable from the TI Fund. Tenant shall reasonably assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s
Work or any portion thereof shall impose terms or conditions upon the construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or
(iii) will materially delay the construction of Landlord’s Work, Landlord and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. Tenant will remove Tenant’s
personal property from and otherwise vacate portions of the Premises in order to allow for construction of Landlord’s Work in accordance with a mutually agreed upon phased construction schedule. Tenant’s failure to vacate portions of the
Premises in accordance with the agreed upon phased construction schedule shall constitute Tenant Delay. 

(c)        Completion of Landlord’s Work. Landlord shall complete or cause to
be completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and normal “punch list” items of a non-material nature that do not interfere with the use of

 7000 Shoreline/Fluidigm 
  

 
the Premises (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s Work, Landlord shall require the TI Architect
and the general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American institute of Architects (“AIA”) document G704. For purposes of this Work
Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI Permit); (ii) to
comply with any request by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or (iv) to make reasonable adjustments for non-material field
deviations or conditions encountered during the construction of Landlord’s Work. 

(d)        Selection of Materials. Where more than one type of material or
structure is indicated on the TI Construction Drawings, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment that Landlord is obligated to supply under this Work Letter,
Landlord shall select the manufacturer thereof in its sole and absolute discretion unless a manufacturer is expressly specified in the approved TI Construction Drawings. 

(e)        Delivery of Landlord’s Work. Tenant’s acceptance of
Landlord’s Work shall not constitute a waiver of: (i) any warranty with respect to workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of
Landlord’s Work with applicable Legal Requirements, or (iii) any claim that Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations and such other changes as are
permitted hereunder) (collectively, a “Construction Defect”). Tenant shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use
reasonable efforts to remedy or cause the responsible contractor to remedy any such Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite
Landlord’s reasonable efforts, fails to remedy such Construction Defect within such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to cooperate, at no cost to Landlord,
with Tenant should Tenant elect to pursue a claim against such contractor, provided that Tenant shall defend with counsel reasonably acceptable to Landlord, indemnify and hold Landlord harmless from and against any claims arising out of or in
connection with any such claim. 
 Tenant shall be entitled to receive the benefit of all construction warranties and manufacturer’s
equipment warranties relating to equipment installed in the Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and suppliers of such equipment, but the cost of any such extended warranties shall
be borne solely out of the TI Fund. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. 
 (f)        Tenant Delay. For purposes of this Lease, “Tenant Delay” shall mean actual delay in the Substantial Completion of Landlord’s Work
caused by any one or more of the following: 
 (i)        Tenant’s
Representative was not available to give or receive any Communication or to take any other action required to be taken by Tenant hereunder within the time periods set forth herein; 

(ii)       Tenant’s request for Change Requests (as defined in Section 4(a)
below) whether or not any such Change Requests are actually performed; 

(iii)      Construction of any Change Requests; 

 7000 Shoreline/Fluidigm 
  

 (iv)        Tenant’s request for
materials, finishes or installations requiring unusually long lead times; 

(v)         Tenant’s delay in reviewing, revising or approving plans and
specifications beyond the periods set forth herein; 
 (vi)        Tenant’s
delay in providing information critical to the normal progression of the Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from
Landlord; 
 (vii)       Tenant’s delay in making payments to Landlord for Excess
TI Costs (as defined in Section 5 below); or 
 (viii)      Any other act or
omission by Tenant or any Tenant Party (as defined in the Lease), or persons employed by any of such persons that continues for more than one (1) day after Landlord’s notice thereof to Tenant. 

If Substantial Completion of Landlord’s Work is delayed for any of the foregoing reasons, then Landlord shall cause the TI Architect to
certify the date on which the Tenant Improvements would have been completed but for such Tenant Delay and such certified date shall be the date of Substantial Completion. Upon request, Landlord will advise Tenant if any materials, finishes or
installations which are requested as part of any Change Request are likely to require unusually long lead times. 

4.        Changes. Any changes requested by Tenant to the Tenant Improvements after
the delivery and approval by Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be subject to the written approval of Landlord and the TI Architect, such approval
not to be unreasonably withheld, conditioned or delayed. 

(a)        Tenant’s Request For Changes. If Tenant shall request changes to
the Tenant Improvements (“Changes”), Tenant shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request
shall detail the nature and extent of any such Change. Such Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, use commercially reasonable efforts to respond to Tenant as soon as is
reasonably possible with an estimate of: (i) the time it will take, and (ii) the architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant to the extent actually
incurred, whether or not such change is implemented). Landlord shall thereafter submit to Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required depending on the extent of
the Change Request), an analysis of the additional cost or savings involved, including, without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which Landlord’s Work will
be Substantially Complete. Any such delay in the completion of Landlord’s Work caused by a Change and specified in an approved Change Request, including any suspension of Landlord’s Work while any such Change is being evaluated or
designed, shall be a Tenant Delay. 
 (b)        Implementation of
Changes. If Tenant: (i) approves in writing the cost or savings and the estimated extension in the time for completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required in connection with
such Change, Landlord shall cause the approved Change to be instituted. 

5.        Costs. 

 7000 Shoreline/Fluidigm 
  

 (a)        Budget For Tenant
Improvements. Before the commencement of construction of the Tenant Improvements, Landlord shall obtain a detailed breakdown by trade of the costs incurred or that will be incurred in connection with the design and construction of the Tenant
Improvements (the “Budget”). The Budget shall be based upon the TI Construction Drawings approved by Tenant and shall include a payment to Landlord of administrative rent (“Administrative Rent”) equal to 2% of the
TI Costs for monitoring and inspecting the construction of the Tenant Improvements and Changes, which sum shall be payable from the TI Fund (as defined in Section 5(d)). Administrative Rent shall include, without limitation, all
out-of-pocket costs, expenses and fees incurred by or on behalf of Landlord arising from, out of, or in connection with monitoring the construction of the Tenant Improvements and Changes, and shall be payable out of the TI Fund. If the Budget is
greater than the TI Allowance, Tenant shall, deposit with Landlord the difference, in cash, prior to the commencement of construction of the Tenant Improvements or Changes, for disbursement by Landlord as described in Section 5(d).

 (b)        TI Allowance. Landlord shall provide to Tenant a tenant
improvement allowance (the “TI Allowance”) of $694,484.00. 
 Tenant shall have no right to the use or benefit (including
any reduction to or payment of Base Rent) of any portion of the TI Allowance not required for the construction of (i) the Tenant Improvements described in the TI Construction Drawings approved pursuant to Section 2(d) or
(ii) any Changes pursuant to Section 4. 
 (c)        Costs
Includable in TI Fund. The TI Fund shall be used solely for the payment of design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the cost of electrical power and
other utilities used in connection with the construction of the Tenant Improvements, Tenant’s project manager (but not in excess of 3% of hard costs of Landlord’s Work), the cost of preparing the TI Construction Drawings, all costs set
forth in the Budget, including Landlord’s Administrative Rent, costs resulting from Changes (collectively, “TI Costs”). Notwithstanding anything to the contrary contained herein, the TI Fund shall not be used to purchase any
furniture, personal property or other non-Building system materials or equipment, including, but not limited to, Tenant’s voice or data cabling, non-ducted biological safety cabinets and other scientific equipment not incorporated into the
Tenant Improvements. 
 (d)        Excess TI Costs. Landlord shall have no
obligation to bear any portion of the cost of any of the Tenant Improvements except to the extent of the TI Allowance. If at any time the remaining TI Costs under the Budget exceed the remaining unexpended TI Allowance, Tenant shall deposit with
Landlord, as a condition precedent to Landlord’s obligation to complete the Tenant Improvements, 100% of the then current TI Cost in excess of the remaining TI Allowance (“Excess TI Costs”). If Tenant fails to deposit any
Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the Default Rate and the right to assess a late charge). For
purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. The TI Allowance and Excess TI Costs are herein referred to as the “TI Fund.” Funds deposited by Tenant shall be
the first disbursed to pay TI Costs. Notwithstanding anything to the contrary set forth in this Section 5(d) but subject to the last sentence of this Section 5(d), Tenant shall be fully and solely liable for TI Costs and the
cost of Minor Variations in excess of the TI Allowance. If upon Substantial Completion of the Tenant Improvements and the payment of all sums due in connection therewith there remains any undisbursed portion of the TI Fund, Tenant shall be entitled
to such undisbursed TI Fund solely to the extent of any Excess TI Costs deposit Tenant has actually made with Landlord. Notwithstanding anything to the contrary in this Work Letter, TI Costs shall not include, and Landlord shall be solely
responsible for, and Tenant shall have no responsibility to pay for the following; (a) costs incurred due to the presence of Hazardous Materials, except to the extent the presence of such Hazardous Materials was caused by Tenant or any Tenant
Party; (b) costs to bring the Premises or the Project into compliance with applicable Legal Requirements, except to the extent related to Tenant’s particular use of the Premises (which the parties agree does not include any Landlord’s
Work shown on the Space Plan); (c) wages, labor and overhead for 

 7000 Shoreline/Fluidigm 
  

 
overtime and premium time in constructing Landlord’s Work, except to the extent set forth in the Budget or otherwise approved by Tenant; and (d) construction costs related to unforeseen
field conditions at the Building in excess of $69,448.40 (it being agreed that Tenant shall be responsible for the first $69,448.40 of such costs, which may be paid using the TI Allowance). 

(e)        Construction Contract.  The contract for construction of
Landlord’s Work shall be written substantially on Landlord’s standard form of construction agreement with modifications reasonably acceptable to Landlord where the contract sum is the costs of the work plus a fee not to exceed a
“Guaranteed Maximum Price” (i.e. construction contracts written on a “Cost Plus” or “Time and Materials” basis are not acceptable) in an amount equal to the construction costs set forth in the approved Budget,
subject to any increases resulting from changes implemented after approval of the Budget. 

6.        Tenant Access.  Landlord and Tenant acknowledge and agree that
Landlord will be performing Landlord’s Work in the Premises during Tenant’s occupancy of the Premises (“Common Area Improvements”). The completion of Landlord’s Work may have a material adverse effect on Tenant’s
use and quiet enjoyment of the Premises and the operation of Tenant’s business at the Premises, including, without limitation, the creation of dust, noise and vibrations, none of which shall constitute a constructive eviction of Tenant, an
interruption of Tenant’s use and quiet enjoyment of the Premises or result in any offset or abatement of Rent whatsoever; provided, however, Landlord shall use commercially reasonable efforts not to interfere with Tenant’s
use of the Premises; provided, that, such efforts shall not require Landlord to incur any additional material cost in performing Landlord’s Work. Notwithstanding anything to the contrary set forth herein, Landlord shall have no liability to
Tenant for any Claims resulting from, arising out of or related to the performance of Landlord’s Work except as otherwise provided in this Work Letter or in the Lease. 

7.        No Interference. Neither Tenant nor any Tenant Party (as defined in the
Lease) shall interfere with the performance of Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities. 

8.        Miscellaneous. 

(a)        Consents. Whenever consent or approval of either party is required under
this Work Letter, that party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to the contrary. 
 (b)        Modification. No modification, waiver or amendment of this Work Letter or of any of its conditions or provisions shall be binding upon Landlord or Tenant
unless in writing signed by Landlord and Tenant. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

 7000 Shoreline/Fluidigm 
  

 SCHEDULE 1 
 SPACE PLAN 

 

 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT D TO LEASE 
 DIAGRAM OF SHARED AREA 

 

 

 

 

			
	Rules and Regulations	 	7000 Shoreline/Fluidigm

  

 EXHIBIT E TO LEASE 
 Rules and Regulations 

1.        The sidewalk, entries, and driveways of the Project shall not be obstructed by
Tenant, or any Tenant Party, or used by them for any purpose other than ingress and egress to and from the Premises. 

2.        Tenant shall not place any objects, including antennas, outdoor furniture, etc.,
in the parking areas, landscaped areas or other areas outside of its Premises, or on the roof of the Project. 

3.        Except for animals assisting the disabled, no animals shall be allowed in the
offices, halls, or corridors in the Project. 
 4.        Tenant shall not disturb
the occupants of the Project or adjoining buildings by the use of any radio or musical instrument or by the making of loud or improper noises. 
 5.        If Tenant desires telegraphic, telephonic or other electric connections in the Premises, Landlord or its agent will direct the electrician as to where and how the
wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted. Any such installation or connection shall be made at Tenant’s expense. 

6.        Tenant shall not install or operate any steam or gas engine or boiler, or other
mechanical apparatus in the Premises, except as specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is expressly prohibited. Explosives or other articles deemed extra hazardous
shall not be brought into the Project. 
 7.        Parking any type of
recreational vehicles is specifically prohibited on or about the Project. Except for the overnight parking of operative vehicles, no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it
shall be removed within 48 hours. There shall be no “For Sale” or other advertising signs on or about any parked vehicle. All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All
parking will be open parking, and no reserved parking, numbering or lettering of individual spaces will be permitted except as specified by Landlord. 
 8.        Tenant shall maintain the Premises free from rodents, insects and other pests. 

9.        Landlord reserves the right to exclude or expel from the Project any person who,
in the judgment of Landlord, is intoxicated or under the influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the Project. 

10.        Tenant shall not cause any unnecessary labor by reason of Tenant’s
carelessness or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring, or for any damage done to the effects of Tenant by the janitors
or any other employee or person. 
 11.        Tenant shall give Landlord prompt
notice of any defects in the water, lawn sprinkler, sewage, gas pipes, electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 

			
	Rules and Regulations	 	7000 Shoreline/Fluidigm

  

 12.        Tenant shall not permit storage
outside the Premises, including without limitation, outside storage of trucks and other vehicles, or dumping of waste or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises.

 13.        All moveable trash receptacles provided by the trash disposal firm
for the Premises must be kept in the trash enclosure areas, if any, provided for that purpose. 

14.        No auction, public or private, will be permitted on the Premises or the Project.

 15.        No awnings shall be placed over the windows in the Premises except
with the prior written consent of Landlord. 
 16.        The Premises shall not
be used for lodging, sleeping or cooking or for any immoral or illegal purposes or for any purpose other than that specified in the Lease. No gaming devices shall be operated in the Premises. 

17.        Tenant shall ascertain from Landlord the maximum amount of electrical current
which can safely be used in the Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use more than such safe capacity. Landlord’s consent to the
installation of electric equipment shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 
 18.        Tenant assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 

19.        Tenant shall not install or operate on the Premises any machinery or mechanical
devices of a nature not directly related to Tenant’s ordinary use of the Premises and shall keep all such machinery free of vibration, noise and air waves which may be transmitted beyond the Premises. 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT F-1 TO LEASE 

TENANT’S PERSONAL PROPERTY 
 All
free-standing lab tables and lab stools (east and west side) 
 All laboratory equipment, including refrigerators, freezers, biosafety
cabinets, ovens, microscopes, incubators, chemical processing benches, Servicor clean benches, DI water polishers, ice maker, etc. 
 All
free standing storage in lab areas (east and west side), including chemical storage cabinets, metro racks, cabinets, shelves 
 Gas
cylinder manifolds (west side) may be removed upon the expiration or earlier termination of this Lease; provided, that, (i) no plumbing behind the walls may be removed and (ii) plumbing is otherwise capped in a manner which maintains the
integrity of the plumbing system. 
 Bulk nitrogen distribution system (west side) may be removed upon the expiration or earlier
termination of this Lease; provided, that, (i) no plumbing behind the walls may be removed and (ii) plumbing is otherwise capped in a manner which maintains the integrity of the plumbing system 

All conference room tables, chairs, credenzas, white boards, etc. (west side) 
 All components in the server room (west side) may be removed upon the expiration or earlier termination of this Lease, including racks, servers, dry fire suppression system, etc. (except components located in the
second floor MPOE room); provided, that, such removal shall not disrupt the server equipment of other tenants or occupants of the Building 
 Training
room tables, chairs, projector screen (east side) 
 All breakroom appliances (east and west side), including refrigerator, microwave,
toaster, dishwasher, coffee makers, water cooler, etc. 
 All cubicle furniture (west side) 
 All shelves in shipping/receiving (east side), except 4 green colored shelves 
 Light blue, single paneled cubicle
furniture (east side) 
 All office chairs, free-standing file cabinets, book shelves, storage cabinets (east and west side) 

All office equipment (east and west side), including printers, plotter, telephones, computers, monitors, etc. 

Phone switch on the west side may be removed upon the expiration or earlier termination of this Lease provided, that, such removal shall not
disrupt the phone switch equipment of other tenants or occupants of the Building 

 7000 Shoreline/Fluidigm 
  

 EXHIBIT F-2 TO LEASE 

LANDLORD’S PERSONAL PROPERTY 

First Floor: 
 (29) Teknion
‘Transit’ metal panel workstations (Approx. 7’-6” x 7’-6”) w/ laminate worksurfaces, mobile pedestals, ‘Chronical’ overhead cabinets, task lights, marker boards and raceways. 

(19) SMED International ‘lifeSPACE’ modular panel offices (Approx 10’ x 13’-6”) w/ standard wall panels, glass wall
panels, maple doors, hardware and electrical box’s. 
 (18) SMED International L-shaped modular desk workstations w/ laminate
worksurfaces, ‘Genius’ overhead bins, pedestal drawers and marker boards. 
 (2) SMED International ‘lifeSPACE’
modular panel conference rooms (Approx. 13’-6” x 20’) w/ standard wall panels, glass wall panels, MDF accent panels, maple door, hardware and electrical box’s. 

(1) MG West 10’ boat shaped maple conference table w/ aluminum legs and Knoll ‘Plexus’ wire management circuit box,
(1) 21” x 60” maple credenza and (1) 4’ x 8’ maple marker board. 
 (1) MG West 7’
trapezoidal maple conference table w/ aluminum legs and Knoll ‘Plexus’ wire management circuit box, (1) 21” x 60” maple credenza. 
 Lunch Room: 
 (12) Marquette 42” round wood tables in random colors. 

(48) Marquette wood side chairs in random colors. 
 (4) Sandler ‘Sevilla’ 42” round stainless steel and aluminum tables 

(12) Liceo outdoor stacking cast aluminum arm chairs. 
 Second Floor: 
 (29) Teknion ‘Transit’ metal panel workstations (Approx.
7’-6” x 7’-6”) w/ laminate worksurfaces, mobile pedestals, ‘Chronical’ overhead cabinets, task lights, marker boards and raceways. 
 (1) Teknion ‘Transit’ metal panel business equipment area (Approx. 8’ x 17’) w/ laminate worksurfaces, ‘Chronical’ overhead cabinets and raceways. 

(19) SMED International ‘lifeSPACE’ modular panel offices (Approx. 10’ x 13’-6”) w/ standard wall panels, glass
wall panels, maple doors, hardware and electrical box’s. 
 (19) SMED International L-shaped modular desk workstations w/
laminate worksurfaces, ‘Genius’ overhead bins, pedestal drawers, marker boards and rolling tables. 
 (1) SMED
International ‘lifeSPACE’ modular panel conference room (Approx. 13’-6” x 23’) w/ standard wall panels, glass wall panels, maple door, hardware and electrical box’s. 

 7000 Shoreline/Fluidigm 
  

 (1) MG West 12’ boat shaped maple conference table w/ aluminum legs and Knoll
‘Plexus’ wire management circuit box, (1) 21” x 72” maple credenza, (1) 4’ x 8’ maple marker board and (1) electric projector screen. 

(1) MG West 20’ boat shaped maple conference table w/ aluminum legs and Knot ‘Plexus’ wire management circuit box,
(2) 21” x 72” maple credenzas, (2) 4’ x 10’ maple marker boards and (1) electric projector screen. 
 (3) Sandler ‘Seville’ 42” round stainless steel and aluminum tables. 

(9) Liceo outdoor stacking cast aluminum arm chairs. 
 (1) Asko Dishwasher. 
 (1) 22’ Gametime shuffleboard ‘Cyclone 2’.

 Fitness Room: 
 (2)
Stairmaster 510 Club Track Mills. 
 (1) Stairmaster 4500 Stepper. 

(2) Stairmaster 3900 Stratus Recumbent bikes. 
 (1) Precor Elliptical Trainer 
 (1) Set dumbells w/ Cybex rack. 

(1) Lemond RevMaster Spinning Bike. 
 (1) Concept 2 Rower 
 (1) Cybex MG-500 Multi Gym w/ bench, leg ext & curl.

 (6) Floor stretching mats. 
 (6) Equipment mats. 
 Security: 
 (130) Keymark (by Medeco) removable lock cores and master key system. 
 (1) Pegasys 2000
NT Security Management and Video Surveillance System including card readers, contacts, alarms, glass break detectors, (18) interior and exterior high resolution digital cameras, color monitor, controllers, reader boards, power supplies,
electronic locks, intercom, computer, recorder and software. 
 Miscellaneous Building and Lab Support: 

(1) Bush OMTS 1 – LA Rotary Screw Vacuum Pump. 
 (1) Atlas Copco GX 7hp Rotary Screw Air Compressor w/ Zander K-MT Ecodry Air Dryer. 

(1) 30 – 160 KVA Uninterruptible Power System with cabinet, controls and battery banks. 

 7000 Shoreline/Fluidigm 
  

 (1) 75 KVA Onan (Cummins) Model 400 DFCE diesel powered emergency generator and transfer
switch. 

					
	First Amendment to Lease - 7000 Shoreline/Fluidigm	  	 	Page 1	  

 FIRST AMENDMENT TO LEASE

 This First Amendment (the “Amendment”) to Lease is made as of September 22, 2010, by and
between ARE-SAN FRANCISCO NO. 17, LLC, a Delaware limited liability company (“Landlord”), and FLUIDIGM CORPORATION, a Delaware corporation (“Tenant”). 

RECITALS 

A.        Landlord and Tenant have entered into that certain Lease (the
“Lease”) dated as of September 14, 2010 (the “Lease”), wherein Landlord leased to Tenant certain premises located at 7000 Shoreline Court, South San Francisco, California, and more particularly described in the
Lease. Initially capitalized terms used and not defined in this Amendment shall have the meanings set forth in the Lease. 

B.        Landlord and Tenant desire to amend the Lease to, among other things, provide for
an increase in the TI Allowance. 
 AGREEMENT 
 Now, therefore, the parties hereto agree that the Lease is amended as follows: 

1.        Base Rent.  The definition of Base Rent as set forth in
the Basic Lease Provisions shall be amended and restated in its entirety as follows: 
 Base Rent: 

 

					
	Period	  	Monthly Base Rent	 
	
                          
                      
	  	 	 	 
	 October 1, 2010 - December 31,
2010
	  	 	$58,672.76	  
	 January 1, 2011 - February 28, 2011
	  	 	$60,191.01	  
	 March 1, 2011 - March 31,
2011
	  	 	$59,527.20	  
	 April 1, 2011 - February 28, 2012
	  	 	$61,527.20	  
	 March 1, 2012 - February 28,
2013
	  	 	$64,007,50	  
	 March 1, 2013 - February 28, 2014
	  	 	$66,487.80	  
	 March 1, 2014
- April 30, 2015
	  	 	$70,208.25	  

2.        Tenant’s Share of Operating Expenses. The definition of
Tenant’s Share of Operating Expenses as set forth in the Basic Lease Provisions shall be amended and restated in its entirety as follows: 
 Tenant’s Share of Operating Expenses: 
  

					
	Period	  	Tenant’s Share	 
	
                          
  
	  	 	 	 
	 October 1, 2010 - February 28,
2011
	  	 	  6.98%	  
	 March 1, 2011 - April 30, 2015
	  	 	18.19%	  
	 Extension Term (if
any)
	  	 	21.43%	  

**Landlord and Tenant acknowledge and agree that the amounts of Tenant’s Share as set forth in the table above are agreed-upon
amounts and do not reflect the proportion that the Rentable Area of the Premises bears to the Rentable Area of the Project 

					
	First Amendment to Lease - 7000 Shoreline/Fluidigm	  	 	Page 2	  

3.        Base Term.  The definition of Base Term as set forth in
the Basic Lease Provisions shall be amended and restated in its entirety as follows: 
 Base
Term:      A term beginning on October 1, 2010 (the “Commencement Date”) and ending on April 30, 2015 

4.        Rent Credit.    Section 3(c) of the
Lease is hereby deleted. 
 5.        Reimbursement for
Improvements.  On or before September 30, 2010, Landlord agrees to make a one-time payment to Tenant in the amount of $360,373.75 as reimbursement for improvements made by Tenant to the Premises. 

6.        Miscellaneous. 

(a)        This Amendment is the entire agreement between the parties with respect to the
subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

(b)        This Amendment is binding upon and shall inure to the benefit of the parties
hereto, their respective agents, employees, representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 

(c)        This Amendment may be executed in any number of counterparts, each of which
shall be deemed an original, but all of which when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided
such signature page is attached to any other counterpart identical thereto except having additional signature pages executed by other parties to this Amendment attached thereto. 

(d)        Except as amended and/or modified by this Amendment, the Lease is hereby
ratified and confirmed and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Amendment. In the event of any conflict between the provisions of this Amendment and the provisions of the Lease, the
provisions of this Amendment shall prevail. Whether or not specifically amended by this Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Amendment.

 (Signatures on Next Page) 

					
	First Amendment to Lease - 7000 Shoreline/Fluidigm	  	 	Page 3	  

 IN WITNESS
WHEREOF, the parties hereto have executed this Amendment as of the day and year first above written. 
  

					
	TENANT:
	
	 FLUIDIGM CORPORATION,
 a
Delaware corporation

		
	 By:
	 	  /s/ Gajus V. Worthington

		
	 Title:
	 	  Chief Executive Officer

	
	LANDLORD:
	
	 ARE-SAN FRANCISCO NO. 17, LLC,

a Delaware limited liability company

		
	 By:
	 	 ALEXANDIA REAL ESTATE EQUITIES, L.P.,

	 a Delaware limited partnership, its managing

member

			
		 	By:	 	     ARE-QRS CORP.,

		 		 	     a Maryland corporation,

		 		 	     its general partner

		
	 By:
	 	  /s/ Eric S. Johnson

		
	 Title:
	 	  Eric S. Johnson, Vice President,

 Real Estate Legal Affairs

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