Document:

Amendment No. 1 to Registration Rights Agreement

 Exhibit 10.14F 
 TERCICA, INC. 
 AMENDMENT NO. 1 TO 
 REGISTRATION RIGHTS AGREEMENT 
 THIS
AMENDMENT NO. 1 (the “Amendment”) to that certain Registration Rights Agreement, dated as of October 13, 2006 (the “Rights Agreement”), is made as of
July 30, 2007 (the “Effective Date”), by and among TERCICA, INC., a Delaware corporation (the “Company”), and the undersigned Holders (the
“Consenting Holders”). 
 RECITALS 
 WHEREAS, the Company and the Consenting Holders are parties to the Rights Agreement; 
 WHEREAS, the Company and the Consenting Holders wish to amend the Rights Agreement as set forth below; and 
 WHEREAS, the Consenting Holders are Holders of at least a majority-in-interest of the Registrable Securities currently outstanding
and, together with the Company, have the right, pursuant to Section 9(a) of the Rights Agreement, to amend Rights Agreement as set forth below. 
 NOW, THEREFORE, in consideration of the mutual agreements, covenants and considerations contained herein, the Company and the Consenting Holders agree as follows: 
 AGREEMENT 
 1.
DEFINITIONS. Capitalized terms not otherwise defined herein shall have the meanings ascribed to them in the Rights Agreement. 
 2. AMENDMENT. 
 2.1 Section 1 of the Rights Agreement is hereby amended to add the following
definitions to the list of defined terms thereunder, each of which shall read in full as follows: 
 “Genentech
means Genentech, Inc., a Delaware corporation.” 
 “Genentech Pro Rata Shares means the shares
of Company Common Stock issued to Suraypharm (and/or its Affiliates) in exercise of Suraypharm’s rights under Section 5.1 of the Affiliation Agreement in connection with the issuance of Genentech Shares.” 
 “Genentech Purchase Agreement means that certain Common Stock Purchase Agreement, dated as of July 6, 2007, by and
between the Company and Genentech.” 
 “Genentech Shares means the shares of Company Common Stock
issued to Genentech pursuant to the Genentech Purchase Agreement.” 
 2.2 Section 1 of the Rights Agreement is hereby
amended to amend the definition of “Registrable Securities” thereunder to read in full as follows: 
 “Registrable Securities means (i) the Shares, the Note Shares, the Warrant Shares and the Genentech Pro Rata Shares, and (ii) all shares of Company Common 

 
Stock related to the Shares, the Note Shares, the Warrant Shares and the Genentech Pro Rata Shares issued in connection with any exchange, conversion, stock
split, stock dividend, distribution, recapitalization or similar event of the Company; provided, however, that Registrable Securities shall not include any of the above shares (i) sold by a person to the public either pursuant to a
Registration Statement or Rule 144 under the Securities Act, (ii) sold to any person in a private transaction in which the right the cause the Company to register Registrable Securities is not assigned pursuant to Section 6, and
(iii) held by a Holder during any such period that all Registrable Securities held by such Holder could be sold without restriction under Rule 144 under the Securities Act during the following ninety day period.” 
 3. MISCELLANEOUS. 
 3.1 Effect of Amendment. Except as modified by the terms of this Amendment, the terms and provisions of the Rights Agreement shall remain in full force and effect. Other than as stated in this Amendment, this Amendment shall not
operate as a waiver of any condition or obligation imposed on the parties under the Rights Agreement. 
 3.2 Amendment. This Amendment
shall not be changed or modified orally, but only by an instrument in writing signed by the parties hereto. 
 3.3 Governing Law. This
Amendment shall be construed in accordance with, and this Amendment and all matters arising out of or relating in any way whatsoever (whether in contract, tort or otherwise) to this Amendment shall be governed by, the law of the State of New York.

 3.4 Successors and Assigns. The provisions hereof shall inure to the benefit of, and be binding upon, the successors and assigns of
the parties hereto and each Holder and Investor, and shall be enforceable by the Company or any Holder or Investor. 
 3.5 Entire
Agreement. The Rights Agreement, as amended by this Amendment, constitutes the full and entire understanding and agreement between the parties with regard to the subject matter hereof. In the event of any conflict, inconsistency, or incongruity
between any provision of this Amendment and any provision of the Rights Agreement, the provisions of this Amendment shall govern and control. 
 3.6 Counterparts. This Amendment may be executed in several counterparts, each of which shall constitute an original and all of which, when taken together, shall constitute one instrument. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 
  

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 IN WITNESS WHEREOF, the parties herein have caused
this Amendment to be duly executed as of the day and year first above written. 
  

													
	 COMPANY:
	 		 		 		 	CONSENTING HOLDERS:
					
	 TERCICA, INC.
	 		 		 		 	IPSEN, S.A.
							
	By:	 	 /s/ Stephen N. Rosenfield
	 		 		 		 	By:	 	 /s/ Raymond de Thezan

		 	Stephen N. Rosenfield	 		 		 		 	Name:	 	Raymond de Thezan
		 	 Executive Vice President of Legal Affairs,
 General
Counsel and Secretary
	 		 		 		 	Title:	 	Company Secretary
						
		 		 		 		 		 	SURAYPHARM
							
		 		 		 		 		 	By:	 	 /s/ Raymond de Thezan

		 		 		 		 		 	Name:	 	Raymond de Thezan
		 		 		 		 		 	Title:	 	Company Secretary

 SIGNATURE PAGE TO AMENDMENT
NO. 1 TO 
 REGISTRATION RIGHTS AGREEMENTSeparation and Release Agreement

 Exhibit 10.1 
 SEPARATION AND RELEASE AGREEMENT 
 This Agreement is entered into by and between Electro Scientific
Industries, Inc. (“ESI”), and John Metcalf (“Employee”) with respect to the following facts: 
 A. Employee’s
employment with ESI ends on September 29, 2007. 
 B. ESI and Employee desire to enter into an agreement regarding Employee’s
separation. 
 The parties agree as follows: 
 1. Wages and Flexible Time Off. On Employee’s last day of employment, Employee received all earned wages and accrued but unused Flexible Time Off pay. 
 2. Separation Pay. In consideration of Employee signing this Agreement, and the covenants and releases given herein, ESI will pay Employee a sum
equal to twenty-six (26) week’s base salary at Employee’s current rate of pay, less applicable withholdings (“Separation Pay”) on the first normal payroll date following January 1, 2008. 
 3. Equity Incentives. 
 a. Stock Options awarded to Employee during his employment will be governed by the terms of the Agreements and Terms and Agreements pursuant to which they were awarded. 
 b. Restricted Stock Units awarded to Employee on the first date of his employment (4,000 units) will become fully vested to the extent not
previously vested, on the final day of his employment with the company. 
 4. Effective Date. The Effective Date of this Agreement
shall be the 8th day after Employee properly signs it, as described in Paragraph 8 below. 
 5. Performance and Duties. Employee
agrees to remain actively at work as requested through September 29, 2007, and to perform duties as requested in a professional and sufficient manner, and to abide by all policies of ESI. Employee agrees now and in the future that Employee will
assist ESI in good faith to the best of Employee’s ability in the defense of any claim brought against ESI or its current or former employees or agents of which Employee has any personal knowledge and ESI agrees it will reimburse
Employee’s reasonable out-of-pocket expenses in providing such assistance. Employee understands that compliance with these Performance and Duties expectations is a condition precedent to being eligible for the Separation Pay and Outplacement.

 5. Confidential Information. Employee agrees not to use or disclose confidential, proprietary or trade secret information learned
while an employee of ESI or its predecessors, including the terms of this Agreement, and covenants not to breach that duty. Confidential, proprietary, and trade secret information may include manufacturing processes, business plans, 

  

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customer lists, drawings, documents, reports, facilities, formulas, computer data, computer programs (including algorithms, flowcharts, source code, object
code, and firmware). This Agreement not to disclose confidential information is consistent with the ESI Employee Confidentiality and Assignment Agreement (“Confidentiality Agreement”), which, if signed by Employee, continues to apply after
employment has ended. If applicable, a copy of the Confidentiality Agreement is attached. Employee also agrees to return any and all ESI property and/or information in Employee’s possession. 
 6. General Release. Employee acknowledges that Employee would not be entitled to receive the Separation Pay and Outplacement provided for herein
absent Employee’s execution of and compliance with this Agreement. In consideration of the Separation Pay and other benefits, Employee, individually and on behalf of Employee’s spouse, heirs and assigns, to the fullest extent permitted
under applicable law, unconditionally releases and discharges ESI, its subsidiaries and their respective directors, officers, shareholders, employees, agents, successors and assigns, all in their representative and individual capacities, and any
related corporations and/or entities from any and all known or unknown liability, damages claims, causes of action or suits of any type related directly or indirectly to Employee’s employment with ESI, and the termination of Employee’s
employment with ESI, including claims under any common law theories, including but not limited to, breach of contract or tort or tort-like theories and under any state or federal, constitutional, civil rights, labor, and employment laws, including
but not limited to, Employee Retirement Income Security Act (ERISA), Title VII of the Civil Rights Act of 1964, the Post Civil War Civil Rights Acts (42 USC §§ 1981-1988), the Civil Rights Act of 1991, the Equal Pay Act, Older
Workers’ Benefit Protection Act, the Age Discrimination in Employment Act, the Americans with Disabilities Act, the Worker Adjustment and Retraining Notification Act, the Rehabilitation Act of 1973, the Uniformed Services Employment and
Reemployment Rights Act, the Fair Labor Standards Act, Executive Order 11246, and the Family and Medical Leave Act, all as amended, including any regulations or guidelines thereunder. 
 This Release shall not affect any rights that Employee may have under health insurance plans or under the 401(k) plan maintained by the Company or for
workers’ compensation benefits. 
 ESI understands and agrees that by signing the Separation and Release Agreement, Employee is not
releasing ESI from its contribution and indemnification obligations under Oregon or other applicable law, or from any coverage under any policy of insurance providing indemnity and related costs for the benefit of Employee. Furthermore, ESI agrees
to indemnify Employee in such case to the extent permissible under Oregon law. 
 7. Release of Rights Under the Older Workers’
Benefit Protection Act (the “Act”). Employee acknowledges that: (a) Employee has been advised in writing to consult with an attorney prior to executing this Agreement; (b) Employee has read the release and understands the
effect of Employee’s release and that Employee is releasing legal rights; (c) Employee is aware of certain rights to which Employee may be entitled under certain statutes and laws identified in the release; (d) Employee has had
adequate time to consider this Agreement; (e) Employee understands the Agreement and agrees to be bound by its terms; and (f) as consideration for executing this Agreement, Employee has received additional benefits and compensation of
value to which Employee would not otherwise be entitled. 
  

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 8. Time for Consideration of Offer. Employee acknowledges that the Company provided Employee with
this Agreement on or before July 27, 2007, and that the offer provided Employee with a period of twenty-one (21) days, or until August 17, 2007, from the date of receipt to consider the offer and this Agreement (the
“consideration period”). In order to be eligible for the severance benefits offered under this Agreement, Employee must execute and return this Agreement no earlier than the last date of employment and no later than August 17, 2007.
After Employee executes this Agreement, Employee has a period of seven (7) days in which Employee may revoke this Agreement in writing delivered to Tracey Jerijervi, ESI Director of Human Resources, and void Employee’s release of claims.
In the event Employee has not executed this Agreement by August 17, 2007, or if Employee revokes it, this offer will expire and Employee will not be entitled to the Separation Pay and Outplacement offered under this Agreement. If Employee signs
this Agreement by August 17, and does not revoke it, it will become effective and irrevocable on the 8th day after Employee signs it (the “Effective Date”) and only then will Employee be entitled to the severance benefits offered
herein. 
 9. General Provisions. 
 a. Employee acknowledges that Employee has been given the opportunity to consult with legal counsel with respect to the matters referenced in this Agreement, and that Employee has obtained and considered the advice of legal counsel as
Employee deems necessary or appropriate. 
 b. This Agreement contains the entire agreement between Employee and ESI and there have been no
promises, inducements or agreements not expressed in this Agreement. 
 c. The provisions of this Agreement shall be considered severable,
such that if any provision or part thereof shall at any time be held invalid under any law or ruling, any and all such other provision(s) or part(s) shall remain in full force and effect and continue to be enforceable. 
 d. This Agreement shall be interpreted, construed, governed and enforced in accordance with the laws of the State of Oregon. 
 e. This Agreement shall be binding upon and inure to the benefit of the parties hereto and their respective heirs, legal representatives, successors and
assigns. 
 f. Nothing in this Agreement shall be construed as an admission of any liability or any wrongdoing by either party to this
Agreement. 
 g. This Agreement shall not be construed against any party on the grounds that such party drafted the Agreement. 
  

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 The undersigned have executed this Agreement on the dates shown below in Portland, Oregon. 
  

					
	Dated: July 27, 2007	 	 /S/ John Metcalf

		 	John Metcalf
		
		 	Electro Scientific Industries, Inc
			
	Dated: July 27, 2007	 	By:	 	 /S/ Nicholas Konidaris

		 		 	Nick Konidaris
		 		 	President & CEO

  

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